[
  {
    "path": ".gitignore",
    "content": "dataset/glove*\n.DS_Store\n.idea/*\n__pycache__/*\nconfig/__pycache__/*\nmodel/__pycache__/*\ncommon/__pycache__/*\ndataset/CONLL/train_manual.txt\ndataset/BC5CDR/train_manual.txt\ndataset/Laptop-reviews/train_manual.txt"
  },
  {
    "path": "README.md",
    "content": "# TriggerNER\nCode & Data for ACL 2020 paper: \n\n[TriggerNER: Learning with Entity Triggers as Explanations for Named Entity Recognition](https://arxiv.org/abs/2004.07493)\n\nAuthors: [Bill Yuchen Lin&ast;](https://yuchenlin.xyz), [Dong-Ho Lee&ast;](https://danny-lee.info/), Ming Shen, [Ryan Moreno](https://ryan-moreno.github.io/), Xiao Huang, [Prashant Shiralkar](https://sites.google.com/site/shiralkarprashant/), [Xiang Ren](http://ink-ron.usc.edu/xiangren/)\n\n\nWe introduce **entity triggers**, an effective proxy of human explanations for facilitating label-efficient learning of NER models. \nWe crowd-sourced 14k entity triggers for two well-studied NER datasets.\nOur proposed model, name Trigger Matching Network, jointly learns trigger representations and soft matching module with self-attention such that can generalize to unseen sentences easily for tagging.\nExpriments show that the framework is significantly more cost-effective such that usinng 20% of the trigger-annotated sentences can result in a comparable performance of conventional supervised approaches using 70% training data.\n\n<p align=\"center\"><img src=\"figure/trig.png\" width=\"800\"/></p>\n\nIf you make use of this code or the entity triggers in your work, please kindly cite the following paper:\n\n```bibtex\n@inproceedings{TriggerNER2020,\n  title={TriggerNER: Learning with Entity Triggers as Explanations for Named Entity Recognition},\n  author={Bill Yuchen Lin and Dong-Ho Lee and Ming Shen and Ryan Moreno and Xiao Huang  and Prashant Shiralkar and Xiang Ren}, \n  booktitle={Proceedings of ACL},\n  year={2020}\n}\n```\n\n\n\n## Quick Links\n* [Requirements](#Requirements)\n* [Trigger Dataset](#Trigger-Dataset)\n* [Train and Test](#train-and-test)\n\n\n## Trigger Dataset\n\n\nThe concept of **entity triggers**, a novel form of explanatory annotation for named entity recognition problems.  \nWe crowd-source and publicly release 14k annotated entity triggers on two popular datasets: \nCoNLL03 (generic domain), BC5CDR (biomedical domain).\n\n`dataset/` saves CONLL, BC5CDR, and Laptop-Reviews dataset. For each directory, \n\n* `train.txt, test.txt, dev.txt` are original dataset\n* `train_20.txt` is for cutting out the original train dataset into 20% for baseline setting. The dataset is used in `naive.py`\n* `trigger_20.txt` is trigger dataset. The dataset is used in `supervised.py` and `semi_supervised.py`.\n\nTo enable 3% of original training dataset, you should use `--percentage 15` since the dataset we used for supervised.py and semi_supervised.py is 20% of original training data with triggers.\n\n## Requirements\nPython >= 3.6 and PyTorch >= 0.4.1\n```bash\npython -m pip install -r requirements.txt\n```\n\n## Train and Test\n* Train/Test Baseline (Bi-LSTM / CRF with 20 % of training dataset) :\n```\npython naive.py --dataset CONLL\npython naive.py --dataset BC5CDR\n```\n\n* Train/Test Trigger Matching Network in supervised setting :\n```\npython supervised.py --dataset CONLL\npython supervised.py --dataset BC5CDR\n```\n\n\n* Train/Test Trigger Matching Network in semi-supervised setting (self-training) :\n```\npython semi_supervised.py --dataset CONLL\npython semi_supervised.py --dataset BC5CDR\n```\n\nOur code is based on https://github.com/allanj/pytorch_lstmcrf. \n\n\n[INK Lab](http://inklab.usc.edu/) at USC\n"
  },
  {
    "path": "common/__init__.py",
    "content": "from common.instance import Instance\nfrom common.sentence import Sentence\n"
  },
  {
    "path": "common/instance.py",
    "content": "#\n# @author: Allan\n# edited by Dong-Ho Lee\n#\nfrom common.sentence import  Sentence\nfrom typing import List\n\nclass Instance:\n    \"\"\"\n    This class is the basic Instance for a datasample\n    \"\"\"\n\n    def __init__(self, input: Sentence, output: List[str] = None, embedding = None, trigger_label = None, trigger_positions = None, trigger_key = None) -> None:\n        \"\"\"\n        Constructor for the instance.\n        :param input: sentence containing the words\n        :param output: a list of labels\n        \"\"\"\n        self.input = input\n        self.output = output\n        self.elmo_vec = embedding #used for loading the ELMo vector.\n        self.word_ids = None\n        self.char_ids = None\n        self.output_ids = None\n        self.is_prediction = None\n        self.trigger_label = trigger_label\n        self.trigger_positions = trigger_positions\n        self.trigger_key = trigger_key\n        self.trigger_vec = None\n        self.trigger_matching_label = None\n\n    def __len__(self):\n        return len(self.input)\n"
  },
  {
    "path": "common/sentence.py",
    "content": "#\n# @author: Allan\n# edited by Dong-Ho Lee\n#\n\nfrom typing import List\n\nclass Sentence:\n    \"\"\"\n    The class for the input sentence\n    \"\"\"\n\n    def __init__(self, words: List[str], pos_tags:List[str] = None):\n        \"\"\"\n\n        :param words:\n        :param pos_tags: By default, it is not required to have the pos tags, in case you need it/\n        \"\"\"\n        self.words = words\n        self.pos_tags = pos_tags\n\n    def __len__(self):\n        return len(self.words)\n\n\n"
  },
  {
    "path": "config/__init__.py",
    "content": "from config.config import Config, ContextEmb, PAD, START, STOP\nfrom config.eval import Span, evaluate_batch_insts\nfrom config.reader import Reader\nfrom config.utils import  log_sum_exp_pytorch, simple_batching, lr_decay, get_optimizer, write_results, batching_list_instances\n"
  },
  {
    "path": "config/config.py",
    "content": "# \n# @author: Allan\n# edited by Dong-Ho Lee\n#\n\nimport numpy as np\nfrom tqdm import tqdm\nfrom typing import List, Tuple, Dict, Union\nfrom common import Instance\nimport torch\nfrom enum import Enum\nimport os\n\nfrom termcolor import colored\n\nSTART = \"<START>\"\nSTOP = \"<STOP>\"\nPAD = \"<PAD>\"\nUNK = \"<UNK>\"\n\nclass ContextEmb(Enum):\n    none = 0\n    elmo = 1\n    bert = 2 # not support yet\n    flair = 3 # not support yet\n\n\nclass Config:\n    def __init__(self, args) -> None:\n        \"\"\"\n        Construct the arguments and some hyperparameters\n        :param args:\n        \"\"\"\n\n        # Predefined label string.\n        self.PAD = PAD\n        self.B = \"B-\"\n        self.I = \"I-\"\n        self.S = \"S-\"\n        self.E = \"E-\"\n        self.O = \"O\"\n        self.START_TAG = START\n        self.STOP_TAG = STOP\n        self.UNK = \"<UNK>\"\n        self.unk_id = -1\n\n        # Model hyper parameters\n        self.embedding_file = args.embedding_file\n        self.embedding_dim = args.embedding_dim\n        self.context_emb = ContextEmb[args.context_emb]\n        self.context_emb_size = 0\n        self.embedding, self.embedding_dim = self.read_pretrain_embedding()\n        self.word_embedding = None\n        self.seed = args.seed\n        self.digit2zero = args.digit2zero\n        self.hidden_dim = args.hidden_dim\n        self.rep_hidden_dim = args.hidden_dim\n        self.use_brnn = True\n        self.num_layers = 1\n        self.dropout = args.dropout\n        self.char_emb_size = 25\n        self.charlstm_hidden_dim = 50\n        self.use_char_rnn = args.use_char_rnn\n        self.use_crf_layer = args.use_crf_layer\n\n        # Data specification\n        self.percentage = args.percentage\n        self.dataset = args.dataset\n        self.train_file = \"dataset/\" + self.dataset + \"/train_20.txt\"\n        self.train_all_file = \"dataset/\" + self.dataset + \"/train.txt\"\n        if self.dataset == \"Laptop-reviews\":\n            self.dev_file = \"dataset/\" + self.dataset + \"/test.txt\"\n        else:\n            self.dev_file = \"dataset/\" + self.dataset + \"/dev.txt\"\n        self.test_file = \"dataset/\" + self.dataset + \"/test.txt\"\n        self.trigger_file = \"dataset/\" + self.dataset + \"/trigger_20.txt\"\n        self.label2idx = {}\n        self.idx2labels = []\n        self.char2idx = {}\n        self.idx2char = []\n        self.num_char = 0\n        self.train_num = args.train_num\n        self.dev_num = args.dev_num\n        self.test_num = args.test_num\n\n\n        # Training hyperparameter\n        self.model_folder = args.model_folder\n        self.optimizer = args.optimizer.lower()\n        self.trig_optimizer = args.trig_optimizer.lower()\n        self.learning_rate = args.learning_rate\n        self.momentum = args.momentum\n        self.l2 = args.l2\n        self.num_epochs = args.num_epochs\n        self.num_epochs_soft = args.num_epochs_soft\n        self.use_dev = True\n        self.batch_size = args.batch_size\n        self.clip = 5\n        self.lr_decay = args.lr_decay\n        self.device = torch.device(args.device)\n        self.ds_setting = args.ds_setting\n        print(self.ds_setting)\n\n    def read_pretrain_embedding(self) -> Tuple[Union[Dict[str, np.array], None], int]:\n        \"\"\"\n        Read the pretrained word embeddings, return the complete embeddings and the embedding dimension\n        :return:\n        \"\"\"\n        print(\"reading the pretraing embedding: %s\" % (self.embedding_file))\n        if self.embedding_file is None:\n            print(\"pretrain embedding in None, using random embedding\")\n            return None, self.embedding_dim\n        else:\n            exists = os.path.isfile(self.embedding_file)\n            if not exists:\n                print(colored(\"[Warning] pretrain embedding file not exists, using random embedding\",  'red'))\n                return None, self.embedding_dim\n                # raise FileNotFoundError(\"The embedding file does not exists\")\n        embedding_dim = -1\n        embedding = dict()\n        with open(self.embedding_file, 'r', encoding='utf-8') as file:\n            for line in tqdm(file.readlines()):\n                line = line.strip()\n                if len(line) == 0:\n                    continue\n                tokens = line.split()\n                if embedding_dim < 0:\n                    embedding_dim = len(tokens) - 1\n                else:\n                    # print(tokens)\n                    # print(embedding_dim)\n                    assert (embedding_dim + 1 == len(tokens))\n                embedd = np.empty([1, embedding_dim])\n                embedd[:] = tokens[1:]\n                first_col = tokens[0]\n                embedding[first_col] = embedd\n        return embedding, embedding_dim\n\n    def build_word_idx(self, train_insts: List[Instance], dev_insts: List[Instance] = None, test_insts: List[Instance] = None) -> None:\n        \"\"\"\n        Build the vocab 2 idx for all instances\n        :param train_insts:\n        :param dev_insts:\n        :param test_insts:\n        :return:\n        \"\"\"\n        self.word2idx = dict()\n        self.idx2word = []\n        self.word2idx[self.PAD] = 0\n        self.idx2word.append(self.PAD)\n        self.word2idx[self.UNK] = 1\n        self.unk_id = 1\n        self.idx2word.append(self.UNK)\n\n        self.char2idx[self.PAD] = 0\n        self.idx2char.append(self.PAD)\n        self.char2idx[self.UNK] = 1\n        self.idx2char.append(self.UNK)\n\n        # extract char on train, dev, test\n        if dev_insts is not None and test_insts is not None:\n            whole_sets = train_insts + dev_insts + test_insts\n        else:\n            whole_sets = train_insts\n\n        for inst in whole_sets:\n            for word in inst.input.words:\n                if word not in self.word2idx:\n                    self.word2idx[word] = len(self.word2idx)\n                    self.idx2word.append(word)\n        # extract char only on train (doesn't matter for dev and test)\n        for inst in train_insts:\n            for word in inst.input.words:\n                for c in word:\n                    if c not in self.char2idx:\n                        self.char2idx[c] = len(self.idx2char)\n                        self.idx2char.append(c)\n        self.num_char = len(self.idx2char)\n\n    def add_word_idx(self, match_insts):\n        for inst in match_insts:\n            for word in inst.input.words:\n                if word not in self.word2idx:\n                    self.word2idx[word] = len(self.word2idx)\n                    self.idx2word.append(word)\n\n    def build_emb_table(self) -> None:\n        \"\"\"\n        build the embedding table with pretrained word embeddings (if given otherwise, use random embeddings)\n        :return:\n        \"\"\"\n        print(\"Building the embedding table for vocabulary...\")\n        scale = np.sqrt(3.0 / self.embedding_dim)\n        if self.embedding is not None:\n            print(\"[Info] Use the pretrained word embedding to initialize: %d x %d\" % (len(self.word2idx), self.embedding_dim))\n            self.word_embedding = np.empty([len(self.word2idx), self.embedding_dim])\n            for word in self.word2idx:\n                if word in self.embedding:\n                    self.word_embedding[self.word2idx[word], :] = self.embedding[word]\n                elif word.lower() in self.embedding:\n                    self.word_embedding[self.word2idx[word], :] = self.embedding[word.lower()]\n                else:\n                    # self.word_embedding[self.word2idx[word], :] = self.embedding[self.UNK]\n                    self.word_embedding[self.word2idx[word], :] = np.random.uniform(-scale, scale, [1, self.embedding_dim])\n        else:\n            self.word_embedding = np.empty([len(self.word2idx), self.embedding_dim])\n            for word in self.word2idx:\n                self.word_embedding[self.word2idx[word], :] = np.random.uniform(-scale, scale, [1, self.embedding_dim])\n\n    def build_label_idx(self, insts: List[Instance]) -> None:\n        \"\"\"\n        Build the mapping from label to index and index to labels.\n        :param insts: list of instances.\n        :return:\n        \"\"\"\n        #self.triggerlabel = {}\n        self.label2idx[self.PAD] = len(self.label2idx)\n        self.idx2labels.append(self.PAD)\n        for inst in insts:\n            for label in inst.output:\n                if label not in self.label2idx:\n                    self.idx2labels.append(label)\n                    self.label2idx[label] = len(self.label2idx)\n                #if label not in [START,STOP,PAD,UNK,'O','T'] and label.split('-')[1] not in self.triggerlabel:\n                #    self.triggerlabel[label.split('-')[1]] = len(self.triggerlabel)\n\n        self.label2idx[self.START_TAG] = len(self.label2idx)\n        self.idx2labels.append(self.START_TAG)\n        self.label2idx[self.STOP_TAG] = len(self.label2idx)\n        self.idx2labels.append(self.STOP_TAG)\n        self.label_size = len(self.label2idx)\n        #self.trig_label_size = len(self.triggerlabel)\n        self.start_label_id = self.label2idx[self.START_TAG]\n        self.stop_label_id = self.label2idx[self.STOP_TAG]\n        print(\"#labels: {}\".format(self.label_size))\n        print(\"label 2idx: {}\".format(self.label2idx))\n\n    def use_iobes(self, insts: List[Instance]) -> None:\n        \"\"\"\n        Use IOBES tagging schema to replace the IOB tagging schema in the instance\n        :param insts:\n        :return:\n        \"\"\"\n        for inst in insts:\n            output = inst.output\n            for pos in range(len(inst)):\n                curr_entity = output[pos]\n                if pos == len(inst) - 1:\n                    if curr_entity.startswith(self.B):\n                        output[pos] = curr_entity.replace(self.B, self.S)\n                    elif curr_entity.startswith(self.I):\n                        output[pos] = curr_entity.replace(self.I, self.E)\n                else:\n                    next_entity = output[pos + 1]\n                    if curr_entity.startswith(self.B):\n                        if next_entity.startswith(self.O) or next_entity.startswith(self.B):\n                            output[pos] = curr_entity.replace(self.B, self.S)\n                    elif curr_entity.startswith(self.I):\n                        if next_entity.startswith(self.O) or next_entity.startswith(self.B):\n                            output[pos] = curr_entity.replace(self.I, self.E)\n\n    def map_insts_ids(self, insts: List[Instance]):\n        \"\"\"\n        Create id for word, char and label in each instance.\n        :param insts:\n        :return:\n        \"\"\"\n        for inst in insts:\n            words = inst.input.words\n            inst.word_ids = []\n            inst.char_ids = []\n            inst.output_ids = [] if inst.output else None\n            for word in words:\n                if word in self.word2idx:\n                    inst.word_ids.append(self.word2idx[word])\n                else:\n                    inst.word_ids.append(self.word2idx[self.UNK])\n                char_id = []\n                for c in word:\n                    if c in self.char2idx:\n                        char_id.append(self.char2idx[c])\n                    else:\n                        char_id.append(self.char2idx[self.UNK])\n                inst.char_ids.append(char_id)\n            if inst.output:\n                for label in inst.output:\n                    if label in self.label2idx:\n                        inst.output_ids.append(self.label2idx[label])\n                    else:\n                        inst.output_ids.append(self.label2idx['O'])\n"
  },
  {
    "path": "config/eval.py",
    "content": "#\n# @author: Allan\n# edited by Dong-Ho Lee\n#\n\nimport numpy as np\nfrom overrides import overrides\nfrom typing import List\nfrom common import Instance\nimport torch\n\nclass Span:\n    \"\"\"\n    A class of `Span` where we use it during evaluation.\n    We construct spans for the convenience of evaluation.\n    \"\"\"\n    def __init__(self, left: int, right: int, type: str):\n        \"\"\"\n        A span compose of left, right (inclusive) and its entity label.\n        :param left:\n        :param right: inclusive.\n        :param type:\n        \"\"\"\n        self.left = left\n        self.right = right\n        self.type = type\n\n    def __eq__(self, other):\n        return self.left == other.left and self.right == other.right and self.type == other.type\n\n    def __hash__(self):\n        return hash((self.left, self.right, self.type))\n\n\ndef evaluate_batch_insts(batch_insts: List[Instance],\n                         batch_pred_ids: torch.LongTensor,\n                         batch_gold_ids: torch.LongTensor,\n                         word_seq_lens: torch.LongTensor,\n                         idx2label: List[str],\n                         use_crf_layer: bool = True) -> np.ndarray:\n    \"\"\"\n    Evaluate a batch of instances and handling the padding positions.\n    :param batch_insts:  a batched of instances.\n    :param batch_pred_ids: Shape: (batch_size, max_length) prediction ids from the viterbi algorithm.\n    :param batch_gold_ids: Shape: (batch_size, max_length) gold ids.\n    :param word_seq_lens: Shape: (batch_size) the length for each instance.\n    :param idx2label: The idx to label mapping.\n    :return: numpy array containing (number of true positive, number of all positive, number of true positive + number of false negative)\n             You can also refer as (number of correctly predicted entities, number of entities predicted, number of entities in the dataset)\n    \"\"\"\n    p = 0\n    total_entity = 0\n    total_predict = 0\n    word_seq_lens = word_seq_lens.tolist()\n    for idx in range(len(batch_pred_ids)):\n        length = word_seq_lens[idx]\n        output = batch_gold_ids[idx][:length].tolist()\n        prediction = batch_pred_ids[idx][:length].tolist()\n        prediction = prediction[::-1] if use_crf_layer else prediction\n        output = [idx2label[l] for l in output]\n        prediction =[idx2label[l] for l in prediction]\n        batch_insts[idx].prediction = prediction\n        #convert to span\n        output_spans = set()\n        start = -1\n        for i in range(len(output)):\n            if output[i].startswith(\"B-\"):\n                start = i\n            if output[i].startswith(\"E-\"):\n                end = i\n                output_spans.add(Span(start, end, output[i][2:]))\n            if output[i].startswith(\"S-\"):\n                output_spans.add(Span(i, i, output[i][2:]))\n        predict_spans = set()\n        for i in range(len(prediction)):\n            if prediction[i].startswith(\"B-\"):\n                start = i\n            if prediction[i].startswith(\"E-\"):\n                end = i\n                predict_spans.add(Span(start, end, prediction[i][2:]))\n            if prediction[i].startswith(\"S-\"):\n                predict_spans.add(Span(i, i, prediction[i][2:]))\n\n        total_entity += len(output_spans)\n        total_predict += len(predict_spans)\n        p += len(predict_spans.intersection(output_spans))\n\n    # In case you need the following code for calculating the p/r/f in a batch.\n    # (When your batch is the complete dataset)\n    # precision = p * 1.0 / total_predict * 100 if total_predict != 0 else 0\n    # recall = p * 1.0 / total_entity * 100 if total_entity != 0 else 0\n    # fscore = 2.0 * precision * recall / (precision + recall) if precision != 0 or recall != 0 else 0\n\n    return np.asarray([p, total_predict, total_entity], dtype=int)\n"
  },
  {
    "path": "config/reader.py",
    "content": "#\n# @author: Allan\n# edited by Dong-Ho Lee\n#\n\nfrom tqdm import tqdm\nfrom common import Sentence, Instance\nfrom typing import List\nimport re\nfrom copy import deepcopy\nimport random\nrandom.seed(1337)\n\nclass Reader:\n\n    def __init__(self, digit2zero:bool=True):\n        \"\"\"\n        Read the dataset into Instance\n        :param digit2zero: convert the digits into 0, which is a common practice for LSTM-CRF.\n        \"\"\"\n        self.digit2zero = digit2zero\n        self.vocab = set()\n\n    def read_txt(self, file: str, number: int = -1) -> List[Instance]:\n        print(\"Reading file: \" + file)\n        insts = []\n        with open(file, 'r', encoding='utf-8') as f:\n            words = []\n            labels = []\n            for line in tqdm(f.readlines()):\n                line = line.rstrip()\n                if line == \"\":\n                    insts.append(Instance(Sentence(words), labels))\n                    words = []\n                    labels = []\n                    if len(insts) == number:\n                        break\n                    continue\n                word, label = line.split()\n                if self.digit2zero:\n                    word = re.sub('\\d', '0', word) # replace digit with 0.\n                words.append(word)\n                self.vocab.add(word)\n                labels.append(label)\n        print(\"number of sentences: {}\".format(len(insts)))\n        return insts\n\n    def read_trigger_txt(self, file: str, percentage, number: int = -1) -> List[Instance]:\n        label_vocab = dict()\n        print(\"Reading file: \" + file)\n        insts = []\n        max_length = 0\n        with open(file, 'r', encoding='utf-8') as f:\n            words = []\n            labels = []\n            word_index = 0\n            for line in tqdm(f.readlines()):\n                line = line.rstrip()\n                if line == \"\":\n                    # check the sequence of index to find entity which consists of multiple words\n                    entity_dict = dict()\n                    for ent in labels:\n                        if ent[0].startswith(\"B-\") or ent[0].startswith(\"I-\") or ent[0].startswith(\"T-\"):\n                            if ent[0].split(\"-\")[1] not in entity_dict:\n                                entity_dict[ent[0].split(\"-\")[1]] = [[words[ent[1]], ent[1]]]\n                            else:\n                                entity_dict[ent[0].split(\"-\")[1]].append([words[ent[1]], ent[1]])\n\n                    # entity word, index, type\n                    trigger_positions = []\n                    trigger_keys = []\n                    for key in entity_dict:\n                        if key in ['0','1','2','3','4','5','6','7','8','9']:\n                            trigger_positions.append([i[1] for i in entity_dict[key]])\n                            trigger_keys.append(\" \".join(i[0] for i in entity_dict[key]))\n                        else:\n                            if key not in label_vocab:\n                                label_vocab[key] = len(label_vocab)\n                            trigger_label = label_vocab[key]\n\n                    final_labels = []\n                    for label in labels:\n                        if label[0].startswith(\"T\"):\n                            final_labels.append(\"O\")\n                        else:\n                            final_labels.append(label[0])\n\n                    for trigger_position, trigger_key in zip(trigger_positions, trigger_keys):\n                        insts.append(Instance(Sentence(words), final_labels, None, trigger_label, trigger_position, trigger_key))\n\n                    #insts.append(Instance(Sentence(words), labels, None, trigger_label, trigger_positions))\n                    if len(words) > max_length:\n                        max_length = len(words)\n                    words = []\n                    labels = []\n                    word_index = 0\n                    if len(insts) == number:\n                        break\n                    continue\n                word, label = line.split()\n\n                if self.digit2zero:\n                    word = re.sub('\\d', '0', word) # replace digit with 0.\n                words.append(word)\n                self.vocab.add(word)\n                labels.append([label, word_index])\n                word_index += 1\n\n        print(\"number of sentences: {}\".format(len(insts)))\n        return insts, max_length, len(label_vocab)\n\n\n    def merge_labels(self, dataset):\n        inst_dictionary = dict()\n\n        for inst in dataset:\n            key = \" \".join(word for word in inst.input.words)\n            if key not in inst_dictionary:\n                inst_dictionary[key] = [inst]\n            else:\n                inst_dictionary[key].append(inst)\n\n        for key in inst_dictionary:\n            candidate_labels = []\n            for inst in inst_dictionary[key]:\n                candidate_labels.append(inst.output)\n\n            final_labels = []\n            for j in range(len(candidate_labels[0])):\n                is_entity = False\n                for i in range(len(candidate_labels)):\n                    if candidate_labels[i][j] != 'O':\n                        final_labels.append(candidate_labels[i][j])\n                        is_entity = True\n                        break\n                if is_entity == False:\n                    final_labels.append('O')\n\n            for inst in inst_dictionary[key]:\n                inst.output = final_labels\n\n    def trigger_percentage(self, dataset, percentage):\n        inst_dictionary = dict()\n\n        for inst in dataset:\n            key = \" \".join(word for word in inst.input.words)\n            if key not in inst_dictionary:\n                inst_dictionary[key] = [inst]\n            else:\n                inst_dictionary[key].append(inst)\n\n        numbers = int(len(inst_dictionary) * percentage / 100)\n        new_inst_keys = list(inst_dictionary.keys())\n\n        random.shuffle(new_inst_keys)\n        new_inst_keys = new_inst_keys[:numbers]\n\n        new_inst = []\n        for key in new_inst_keys:\n            new_inst.extend(inst_dictionary[key])\n\n        return new_inst"
  },
  {
    "path": "config/utils.py",
    "content": "#\n# @author: Allan\n# edited by Dong-Ho Lee\n#\n\nfrom typing import List\nfrom common import Instance\nimport torch.optim as optim\nimport pickle\nimport os.path\nfrom config import PAD, ContextEmb, Config\nfrom termcolor import colored\nimport torch\nimport torch.nn as nn\n\ndef log_sum_exp_pytorch(vec: torch.Tensor) -> torch.Tensor:\n    \"\"\"\n    Calculate the log_sum_exp trick for the tensor.\n    :param vec: [batchSize * from_label * to_label].\n    :return: [batchSize * to_label]\n    \"\"\"\n    maxScores, idx = torch.max(vec, 1)\n    maxScores[maxScores == -float(\"Inf\")] = 0\n    maxScoresExpanded = maxScores.view(vec.shape[0] ,1 , vec.shape[2]).expand(vec.shape[0], vec.shape[1], vec.shape[2])\n    return maxScores + torch.log(torch.sum(torch.exp(vec - maxScoresExpanded), 1))\n\n\ndef batching_list_instances(config: Config, insts: List[Instance], is_soft=False, is_naive=False):\n    train_num = len(insts)\n    batch_size = config.batch_size\n    total_batch = train_num // batch_size + 1 if train_num % batch_size != 0 else train_num // batch_size\n    batched_data = []\n    for batch_id in range(total_batch):\n        one_batch_insts = insts[batch_id * batch_size:(batch_id + 1) * batch_size]\n        batched_data.append(simple_batching(config, one_batch_insts, is_soft, is_naive))\n    return batched_data\n\n\ndef simple_batching(config, insts: List[Instance], is_soft=False, is_naive=False):\n    batch_size = len(insts)\n    batch_data = insts\n    label_size = config.label_size\n\n    word_seq_len = torch.LongTensor(list(map(lambda inst: len(inst.input.words), batch_data)))\n    max_seq_len = word_seq_len.max()\n    char_seq_len = torch.LongTensor([list(map(len, inst.input.words)) + [1] * (int(max_seq_len) - len(inst.input.words)) for inst in batch_data])\n    max_char_seq_len = char_seq_len.max()\n\n    context_emb_tensor = None\n    if config.context_emb != ContextEmb.none:\n        emb_size = insts[0].elmo_vec.shape[1]\n        context_emb_tensor = torch.zeros((batch_size, max_seq_len, emb_size))\n\n    word_seq_tensor = torch.zeros((batch_size, max_seq_len), dtype=torch.long)\n    label_seq_tensor = torch.zeros((batch_size, max_seq_len), dtype=torch.long)\n    char_seq_tensor = torch.zeros((batch_size, max_seq_len, max_char_seq_len), dtype=torch.long)\n\n    annotation_mask = None\n    if batch_data[0].is_prediction is not None:\n        annotation_mask = torch.zeros((batch_size, max_seq_len, label_size), dtype=torch.long)\n\n\n    trigger_label_seq_tensor = None\n    if batch_data[0].trigger_label is not None and is_naive == False:\n        trigger_label_seq_tensor = torch.LongTensor(list(map(lambda inst: inst.trigger_label, batch_data)))\n\n    trigger_vec_tensor = None\n    if batch_data[0].trigger_vec is not None and is_naive == False:\n        trigger_vec_tensor = []\n\n    for idx in range(batch_size):\n        word_seq_tensor[idx, :word_seq_len[idx]] = torch.LongTensor(batch_data[idx].word_ids)\n        if batch_data[idx].output_ids:\n            label_seq_tensor[idx, :word_seq_len[idx]] = torch.LongTensor(batch_data[idx].output_ids)\n        if config.context_emb != ContextEmb.none:\n            context_emb_tensor[idx, :word_seq_len[idx], :] = batch_data[idx].elmo_vec[1:batch_data[idx].elmo_vec.shape[0] - 1, :]\n        if batch_data[idx].is_prediction is not None:\n            for pos in range(len(batch_data[idx].input)):\n                if batch_data[idx].is_prediction[pos]:\n                    annotation_mask[idx, pos, :] = 1\n                    annotation_mask[idx, pos, config.start_label_id] = 0\n                    annotation_mask[idx, pos, config.stop_label_id] = 0\n                else:\n                    annotation_mask[idx, pos, batch_data[idx].output_ids[pos]] = 1\n            annotation_mask[idx, word_seq_len[idx]:, :] = 1\n        for word_idx in range(word_seq_len[idx]):\n            char_seq_tensor[idx, word_idx, :char_seq_len[idx, word_idx]] = torch.LongTensor(batch_data[idx].char_ids[word_idx])\n        for wordIdx in range(word_seq_len[idx], max_seq_len):\n            char_seq_tensor[idx, wordIdx, 0: 1] = torch.LongTensor([config.char2idx[PAD]])\n        if batch_data[idx].trigger_vec is not None and is_naive == False:\n            trigger_vec_tensor.append(batch_data[idx].trigger_vec)\n\n    word_seq_tensor = word_seq_tensor.to(config.device)\n    label_seq_tensor = label_seq_tensor.to(config.device)\n    char_seq_tensor = char_seq_tensor.to(config.device)\n    word_seq_len = word_seq_len.to(config.device)\n    char_seq_len = char_seq_len.to(config.device)\n    annotation_mask = annotation_mask.to(config.device) if annotation_mask is not None else None\n\n    trigger_label_seq_tensor = trigger_label_seq_tensor.to(config.device) if trigger_label_seq_tensor is not None else None\n    trigger_position_seq_tensor = [batch_data[idx].trigger_positions for idx in range(batch_size)] if batch_data[0].trigger_positions is not None else None\n\n    if is_soft:\n        return word_seq_tensor, word_seq_len, context_emb_tensor, char_seq_tensor, char_seq_len, annotation_mask, label_seq_tensor, torch.stack(trigger_vec_tensor)\n    else:\n        return word_seq_tensor, word_seq_len, context_emb_tensor, char_seq_tensor, char_seq_len, annotation_mask, label_seq_tensor, trigger_position_seq_tensor, trigger_label_seq_tensor\n\n\n\ndef lr_decay(config, optimizer: optim.Optimizer, epoch: int) -> optim.Optimizer:\n    \"\"\"\n    Method to decay the learning rate\n    :param config: configuration\n    :param optimizer: optimizer\n    :param epoch: epoch number\n    :return:\n    \"\"\"\n    lr = config.learning_rate / (1 + config.lr_decay * (epoch - 1))\n    for param_group in optimizer.param_groups:\n        param_group['lr'] = lr\n    print('learning rate is set to: ', lr)\n    return optimizer\n\n\ndef load_bert_vec(file: str, insts: List[Instance]):\n\n    if os.path.exists(file.split('.')[0]+'.vec'):\n        f = open(file.split('.')[0]+'.vec', 'rb')\n        bert_embedding = pickle.load(f)\n        f.close()\n        size = 0\n        for vec, inst in zip(bert_embedding, insts):\n            inst.elmo_vec = vec\n            size = vec.shape[1]\n            assert (vec.shape[0] == len(inst.input.words)+2)\n        return size\n\n    else:\n        f = open(file.split('.')[0]+'.vec', 'wb')\n        sentence_list = []\n        for sent in insts:\n            sentence = \" \".join(str(w) for w in sent.input.words)\n            sentence_list.append(sentence)\n\n        sentence_list = tuple(sentence_list)\n        bert_embedding = get_bert_embedding(sentence_list)\n        pickle.dump(bert_embedding, f)\n        f.close()\n\n        size = 0\n        for vec, inst in zip(bert_embedding, insts):\n            inst.elmo_vec = vec\n            size = vec.shape[1]\n            assert (vec.shape[0] == len(inst.input.words)+2)\n        return size\n\n\ndef get_bert_embedding(batch):\n    tokenizer = BertTokenizer.from_pretrained('bert-base-uncased', do_lower_case=True)\n    bert = BertModel.from_pretrained('bert-base-uncased')\n    final_dataset = []\n    for sentence in tqdm(batch):\n        tokenized_sentence = [\"[CLS]\"] + tokenizer.tokenize(sentence) + [\"[SEP]\"]\n\n        # pooling operation (BERT - first)\n        isSubword = False\n        firstSubwordList = []\n        for t_id, token in enumerate(tokenized_sentence):\n            if token.startswith(\"#\") == False:\n                isSubword = False\n                firstSubwordList.append(t_id)\n            if isSubword:\n                continue\n            if token.startswith(\"#\"):\n                isSubword = True\n\n        input_ids = torch.tensor(tokenizer.convert_tokens_to_ids(tokenized_sentence)).unsqueeze(0)\n        outputs = bert(input_ids)\n        embeddings = outputs[0][0]\n        sentence_embedding = tuple()\n        for ind in firstSubwordList:\n            sentence_embedding = sentence_embedding + (embeddings[:, ind, :],)\n        sentence_embedding = torch.cat(sentence_embedding, dim=0)\n        final_dataset.append(sentence_embedding)\n\n    return final_dataset\n\n\ndef get_optimizer(config: Config, model: nn.Module, name=None):\n    params = model.parameters()\n    if name is not None and name == \"adam\":\n        print(colored(\"Using Adam\", 'yellow'))\n        return optim.Adam(params)\n    elif name is not None and name == \"sgd\":\n        print(\n            colored(\"Using SGD: lr is: {}, L2 regularization is: {}\".format(config.learning_rate, config.l2), 'yellow'))\n        return optim.SGD(params, lr=config.learning_rate, weight_decay=float(config.l2))\n    elif config.optimizer.lower() == \"sgd\":\n        print(\n            colored(\"Using SGD: lr is: {}, L2 regularization is: {}\".format(config.learning_rate, config.l2), 'yellow'))\n        return optim.SGD(params, lr=config.learning_rate, weight_decay=float(config.l2))\n    elif config.optimizer.lower() == \"adam\":\n        print(colored(\"Using Adam\", 'yellow'))\n        return optim.Adam(params)\n    else:\n        print(\"Illegal optimizer: {}\".format(config.optimizer))\n        exit(1)\n\n\ndef write_results(filename: str, insts):\n    f = open(filename, 'w', encoding='utf-8')\n    for inst in insts:\n        for i in range(len(inst.input)):\n            words = inst.input.words\n            output = inst.output\n            prediction = inst.prediction\n            assert len(output) == len(prediction)\n            f.write(\"{}\\t{}\\t{}\\t{}\\n\".format(i, words[i], output[i], prediction[i]))\n        f.write(\"\\n\")\n    f.close()"
  },
  {
    "path": "dataset/BC5CDR/dev.txt",
    "content": "22\tB-Chemical\n-\tI-Chemical\noxacalcitriol\tI-Chemical\nsuppresses\tO\nsecondary\tB-Disease\nhyperparathyroidism\tI-Disease\nwithout\tO\ninducing\tO\nlow\tB-Disease\nbone\tI-Disease\nturnover\tI-Disease\nin\tO\ndogs\tO\nwith\tO\nrenal\tB-Disease\nfailure\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nCalcitriol\tB-Chemical\ntherapy\tO\nsuppresses\tO\nserum\tO\nlevels\tO\nof\tO\nparathyroid\tO\nhormone\tO\n(\tO\nPTH\tO\n)\tO\nin\tO\npatients\tO\nwith\tO\nrenal\tB-Disease\nfailure\tI-Disease\nbut\tO\nhas\tO\nseveral\tO\ndrawbacks\tO\n,\tO\nincluding\tO\nhypercalcemia\tB-Disease\nand\tO\n/\tO\nor\tO\nmarked\tO\nsuppression\tB-Disease\nof\tI-Disease\nbone\tI-Disease\nturnover\tI-Disease\n,\tO\nwhich\tO\nmay\tO\nlead\tO\nto\tO\nadynamic\tB-Disease\nbone\tI-Disease\ndisease\tI-Disease\n.\tO\n\nA\tO\nnew\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nanalogue\tO\n,\tO\n22\tB-Chemical\n-\tI-Chemical\noxacalcitriol\tI-Chemical\n(\tO\nOCT\tB-Chemical\n)\tO\n,\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nhave\tO\npromising\tO\ncharacteristics\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ndetermine\tO\nthe\tO\neffects\tO\nof\tO\nOCT\tB-Chemical\non\tO\nserum\tO\nPTH\tO\nlevels\tO\nand\tO\nbone\tO\nturnover\tO\nin\tO\nstates\tO\nof\tO\nnormal\tO\nor\tO\nimpaired\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nSixty\tO\ndogs\tO\nwere\tO\neither\tO\nnephrectomized\tO\n(\tO\nNx\tO\n,\tO\nN\tO\n=\tO\n38\tO\n)\tO\nor\tO\nsham\tO\n-\tO\noperated\tO\n(\tO\nSham\tO\n,\tO\nN\tO\n=\tO\n22\tO\n)\tO\n.\tO\n\nThe\tO\nanimals\tO\nreceived\tO\nsupplemental\tO\nphosphate\tB-Chemical\nto\tO\nenhance\tO\nPTH\tO\nsecretion\tO\n.\tO\n\nFourteen\tO\nweeks\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\nphosphate\tB-Chemical\nsupplementation\tO\n,\tO\nhalf\tO\nof\tO\nthe\tO\nNx\tO\nand\tO\nSham\tO\ndogs\tO\nreceived\tO\ndoses\tO\nof\tO\nOCT\tB-Chemical\n(\tO\nthree\tO\ntimes\tO\nper\tO\nweek\tO\n)\tO\n;\tO\nthe\tO\nother\tO\nhalf\tO\nwere\tO\ngiven\tO\nvehicle\tO\nfor\tO\n60\tO\nweeks\tO\n.\tO\n\nThereafter\tO\n,\tO\nthe\tO\ntreatment\tO\nmodalities\tO\nfor\tO\na\tO\nsubset\tO\nof\tO\nanimals\tO\nwere\tO\ncrossed\tO\nover\tO\nfor\tO\nan\tO\nadditional\tO\neight\tO\nmonths\tO\n.\tO\n\nBiochemical\tO\nand\tO\nhormonal\tO\nindices\tO\nof\tO\ncalcium\tB-Chemical\nand\tO\nbone\tO\nmetabolism\tO\nwere\tO\nmeasured\tO\nthroughout\tO\nthe\tO\nstudy\tO\n,\tO\nand\tO\nbone\tO\nbiopsies\tO\nwere\tO\ndone\tO\nat\tO\nbaseline\tO\n,\tO\n60\tO\nweeks\tO\nafter\tO\nOCT\tB-Chemical\nor\tO\nvehicle\tO\ntreatment\tO\n,\tO\nand\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\ncrossover\tO\nperiod\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIn\tO\nNx\tO\ndogs\tO\n,\tO\nOCT\tB-Chemical\nsignificantly\tO\ndecreased\tO\nserum\tO\nPTH\tO\nlevels\tO\nsoon\tO\nafter\tO\nthe\tO\ninduction\tO\nof\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\n.\tO\n\nIn\tO\nlong\tO\n-\tO\nstanding\tO\nsecondary\tB-Disease\nhyperparathyroidism\tI-Disease\n,\tO\nOCT\tB-Chemical\n(\tO\n0\tO\n.\tO\n03\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\nstabilized\tO\nserum\tO\nPTH\tO\nlevels\tO\nduring\tO\nthe\tO\nfirst\tO\nmonths\tO\n.\tO\n\nSerum\tO\nPTH\tO\nlevels\tO\nrose\tO\nthereafter\tO\n,\tO\nbut\tO\nthe\tO\nrise\tO\nwas\tO\nless\tO\npronounced\tO\ncompared\tO\nwith\tO\nbaseline\tO\nthan\tO\nthe\tO\nrise\tO\nseen\tO\nin\tO\nNx\tO\ncontrol\tO\n.\tO\n\nThese\tO\neffects\tO\nwere\tO\naccompanied\tO\nby\tO\nepisodes\tO\nof\tO\nhypercalcemia\tB-Disease\nand\tO\nhyperphosphatemia\tB-Disease\n.\tO\n\nIn\tO\nanimals\tO\nwith\tO\nnormal\tO\nrenal\tO\nfunction\tO\n,\tO\nOCT\tB-Chemical\ninduced\tO\na\tO\ntransient\tO\ndecrease\tO\nin\tO\nserum\tO\nPTH\tO\nlevels\tO\nat\tO\na\tO\ndose\tO\nof\tO\n0\tO\n.\tO\n1\tO\nmicrog\tO\n/\tO\nkg\tO\n,\tO\nwhich\tO\nwas\tO\nnot\tO\nsustained\tO\nwith\tO\nlowering\tO\nof\tO\nthe\tO\ndoses\tO\n.\tO\n\nIn\tO\nNx\tO\ndogs\tO\n,\tO\nOCT\tB-Chemical\nreversed\tO\nabnormal\tO\nbone\tO\nformation\tO\n,\tO\nsuch\tO\nas\tO\nwoven\tB-Disease\nosteoid\tI-Disease\nand\tO\nfibrosis\tB-Disease\n,\tO\nbut\tO\ndid\tO\nnot\tO\nsignificantly\tO\nalter\tO\nthe\tO\nlevel\tO\nof\tO\nbone\tO\nturnover\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nOCT\tB-Chemical\nimproved\tO\nmineralization\tO\nlag\tO\ntime\tO\n,\tO\n(\tO\nthat\tO\nis\tO\n,\tO\nthe\tO\nrate\tO\nat\tO\nwhich\tO\nosteoid\tO\nmineralizes\tO\n)\tO\nin\tO\nboth\tO\nNx\tO\nand\tO\nSham\tO\ndogs\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\neven\tO\nthough\tO\nOCT\tB-Chemical\ndoes\tO\nnot\tO\ncompletely\tO\nprevent\tO\nthe\tO\noccurrence\tO\nof\tO\nhypercalcemia\tB-Disease\nin\tO\nexperimental\tO\ndogs\tO\nwith\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\n,\tO\nit\tO\nmay\tO\nbe\tO\nof\tO\nuse\tO\nin\tO\nthe\tO\nmanagement\tO\nof\tO\nsecondary\tB-Disease\nhyperparathyroidism\tI-Disease\nbecause\tO\nit\tO\ndoes\tO\nnot\tO\ninduce\tO\nlow\tB-Disease\nbone\tI-Disease\nturnover\tI-Disease\nand\tO\n,\tO\ntherefore\tO\n,\tO\ndoes\tO\nnot\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nadynamic\tB-Disease\nbone\tI-Disease\ndisease\tI-Disease\n.\tO\n\nHypotension\tB-Disease\n,\tO\nbradycardia\tB-Disease\n,\tO\nand\tO\nasystole\tB-Disease\nafter\tO\nhigh\tO\n-\tO\ndose\tO\nintravenous\tO\nmethylprednisolone\tB-Chemical\nin\tO\na\tO\nmonitored\tO\npatient\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nhypotension\tB-Disease\n,\tO\nbradycardia\tB-Disease\n,\tO\nand\tO\nasystole\tB-Disease\nafter\tO\nintravenous\tO\nadministration\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\nmethylprednisolone\tB-Chemical\nin\tO\na\tO\n73\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\nwho\tO\nunderwent\tO\nelectrocardiographic\tO\n(\tO\nECG\tO\n)\tO\nmonitoring\tO\nthroughout\tO\nthe\tO\nepisode\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nhistory\tO\nof\tO\nischemic\tB-Disease\ncardiac\tB-Disease\ndisease\tI-Disease\n9\tO\nyears\tO\nearlier\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nadmitted\tO\nwith\tO\na\tO\npulmonary\tB-Disease\n-\tI-Disease\nrenal\tI-Disease\nsyndrome\tI-Disease\nwith\tO\nhemoptysis\tB-Disease\n,\tO\nrapidly\tO\nprogressive\tO\nrenal\tB-Disease\nfailure\tI-Disease\n,\tO\nand\tO\nhypoxemia\tB-Disease\nthat\tO\nrequired\tO\nmechanical\tO\nventilation\tO\nin\tO\nthe\tO\nintensive\tO\ncare\tO\nunit\tO\n.\tO\n\nAfter\tO\nreceiving\tO\nadvanced\tO\ncardiopulmonary\tO\nresuscitation\tO\n,\tO\nthe\tO\npatient\tO\nrecovered\tO\ncardiac\tO\nrhythm\tO\n.\tO\n\nThe\tO\nECG\tO\nshowed\tO\na\tO\njunctional\tO\nrhythm\tO\nwithout\tO\nventricular\tB-Disease\narrhythmia\tI-Disease\n.\tO\n\nThis\tO\nstudy\tO\nreviews\tO\nthe\tO\ncurrent\tO\nproposed\tO\nmechanisms\tO\nof\tO\nsudden\tB-Disease\ndeath\tI-Disease\nafter\tO\na\tO\nhigh\tO\ndose\tO\nof\tO\nintravenous\tO\nmethylprednisolone\tB-Chemical\n(\tO\nIVMP\tB-Chemical\n)\tO\n.\tO\n\nThese\tO\nmechanisms\tO\nare\tO\nnot\tO\nwell\tO\nunderstood\tO\nbecause\tO\n,\tO\nin\tO\nmost\tO\ncases\tO\n,\tO\nthe\tO\npatients\tO\nwere\tO\nnot\tO\nmonitored\tO\nat\tO\nthe\tO\nmoment\tO\nof\tO\nthe\tO\nevent\tO\n.\tO\n\nRapid\tO\ninfusion\tO\nand\tO\nunderlying\tO\ncardiac\tB-Disease\ndisease\tI-Disease\nwere\tO\nimportant\tO\nrisk\tO\nfactors\tO\nin\tO\nthe\tO\ncase\tO\nreported\tO\nhere\tO\n,\tO\nand\tO\nthe\tO\nauthors\tO\ndiscount\tO\nventricular\tB-Disease\narrhythmia\tI-Disease\nas\tO\nthe\tO\nmain\tO\nmechanism\tO\n.\tO\n\nWorsening\tO\nof\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nby\tO\nmotor\tO\nand\tO\nmental\tO\ntasks\tO\n.\tO\n\nTen\tO\npatients\tO\nwho\tO\nhad\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nwith\tO\ndisabling\tO\ndyskinesia\tB-Disease\nwere\tO\nincluded\tO\nin\tO\nthis\tO\nstudy\tO\nto\tO\nevaluate\tO\nthe\tO\nrole\tO\nof\tO\nmental\tO\n(\tO\nmental\tO\ncalculation\tO\n)\tO\nand\tO\nmotor\tO\n(\tO\nflexion\tO\n/\tO\nextension\tO\nof\tO\nright\tO\nfingers\tO\n,\tO\nflexion\tO\n/\tO\nextension\tO\nof\tO\nleft\tO\nfingers\tO\n,\tO\nflexion\tO\n/\tO\nextension\tO\nof\tO\nthe\tO\nneck\tO\n,\tO\nspeaking\tO\naloud\tO\n)\tO\ntasks\tO\non\tO\nthe\tO\nworsening\tO\nof\tO\npeak\tO\n-\tO\ndose\tO\ndyskinesia\tB-Disease\nfollowing\tO\nadministration\tO\nof\tO\nan\tO\neffective\tO\nsingle\tO\ndose\tO\nof\tO\napomorphine\tB-Chemical\n.\tO\n\nCompared\tO\nwith\tO\nthe\tO\nscore\tO\nat\tO\nrest\tO\n(\tO\n1\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n3\tO\n)\tO\n,\tO\na\tO\nsignificant\tO\naggravation\tO\nof\tO\nthe\tO\ndyskinesia\tB-Disease\nscore\tO\nwas\tO\nobserved\tO\nduring\tO\nspeaking\tO\naloud\tO\n(\tO\n5\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n1\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nmovements\tO\nof\tO\nright\tO\n(\tO\n4\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n0\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nleft\tO\n(\tO\n3\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n8\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nfingers\tO\n,\tO\nmovements\tO\nof\tO\nthe\tO\nneck\tO\n(\tO\n5\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n0\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nand\tO\nmental\tO\ncalculation\tO\n(\tO\n3\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n0\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nactivation\tO\ntasks\tO\nsuch\tO\nas\tO\n\"\tO\nspeaking\tO\naloud\tO\n\"\tO\ncould\tO\nbe\tO\nused\tO\nfor\tO\nobjective\tO\nassessment\tO\nof\tO\ndyskinesia\tB-Disease\nseverity\tO\n.\tO\n\nUrine\tO\nN\tO\n-\tO\nacetyl\tO\n-\tO\nbeta\tO\n-\tO\nD\tO\n-\tO\nglucosaminidase\tO\n-\tO\n-\tO\na\tO\nmarker\tO\nof\tO\ntubular\tO\ndamage\tO\n?\tO\n\nBACKGROUND\tO\n:\tO\nAlthough\tO\nan\tO\nindicator\tO\nof\tO\nrenal\tB-Disease\ntubular\tI-Disease\ndysfunction\tI-Disease\n,\tO\nan\tO\nincreased\tO\nurinary\tO\nN\tO\n-\tO\nacetyl\tO\n-\tO\nbeta\tO\n-\tO\nD\tO\n-\tO\nglucosaminidase\tO\n(\tO\nNAG\tO\n)\tO\nactivity\tO\nmight\tO\nreflect\tO\nincreased\tO\nlysosomal\tO\nactivity\tO\nin\tO\nrenal\tO\ntubular\tO\ncells\tO\n.\tO\n\nMETHODS\tO\n:\tO\nPuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n)\tO\nwas\tO\nadministered\tO\nto\tO\nSprague\tO\nDawley\tO\nrats\tO\nto\tO\ninduce\tO\nproteinuria\tB-Disease\n.\tO\n\nTotal\tO\nprotein\tO\n,\tO\nalbumin\tO\n,\tO\nNAG\tO\nactivity\tO\nand\tO\nprotein\tO\nelectrophoretic\tO\npattern\tO\nwere\tO\nassessed\tO\nin\tO\ndaily\tO\nurine\tO\nsamples\tO\nfor\tO\n33\tO\ndays\tO\n.\tO\n\nThe\tO\nmorphological\tO\nappearance\tO\nof\tO\nthe\tO\nkidneys\tO\nwas\tO\nexamined\tO\non\tO\ndays\tO\nthree\tO\n,\tO\nfour\tO\n,\tO\nsix\tO\n,\tO\neight\tO\nand\tO\nthirty\tO\nthree\tO\nand\tO\nthe\tO\nNAG\tO\nisoenzyme\tO\npatterns\tO\non\tO\ndays\tO\nzero\tO\n,\tO\nfour\tO\n,\tO\neight\tO\nand\tO\nthirty\tO\nthree\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFollowing\tO\nintravenous\tO\nPAN\tB-Chemical\nurine\tO\nvolume\tO\nand\tO\nurine\tO\nNAG\tO\nactivity\tO\nincreased\tO\nsignificantly\tO\nby\tO\nday\tO\ntwo\tO\n,\tO\nbut\tO\nreturned\tO\nto\tO\nnormal\tO\nby\tO\nday\tO\nfour\tO\n.\tO\n\nAfter\tO\nday\tO\nfour\tO\nall\tO\ntreated\tO\nanimals\tO\nexhibited\tO\na\tO\nmarked\tO\nrise\tO\nin\tO\nurine\tO\nalbumin\tO\n,\tO\ntotal\tO\nprotein\tO\nexcretion\tO\nand\tO\nNAG\tO\nactivity\tO\n.\tO\n\nElectrophoresis\tO\nshowed\tO\na\tO\ngeneralised\tO\nincrease\tO\nin\tO\nmiddle\tO\nand\tO\nhigh\tO\nmolecular\tO\nweight\tO\nurine\tO\nproteins\tO\nfrom\tO\nday\tO\nfour\tO\nonwards\tO\n.\tO\n\nProtein\tO\ndroplets\tO\nfirst\tO\nappeared\tO\nprominent\tO\nin\tO\ntubular\tO\ncells\tO\non\tO\nday\tO\nfour\tO\n.\tO\n\nPeak\tO\nurine\tO\nNAG\tO\nactivity\tO\nand\tO\na\tO\nchange\tO\nin\tO\nNAG\tO\nisoenzyme\tO\npattern\tO\ncoincided\tO\nwith\tO\nboth\tO\nthe\tO\npeak\tO\nproteinuria\tB-Disease\nand\tO\nthe\tO\nreduction\tO\nin\tO\nintracellular\tO\nprotein\tO\nand\tO\nNAG\tO\ndroplets\tO\n(\tO\nday\tO\nsix\tO\nonwards\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThis\tO\nanimal\tO\nmodel\tO\ndemonstrates\tO\nthat\tO\nan\tO\nincrease\tO\nin\tO\nlysosomal\tO\nturnover\tO\nand\tO\nhence\tO\nurine\tO\nNAG\tO\nactivity\tO\n,\tO\noccurs\tO\nwhen\tO\nincreased\tO\nprotein\tO\nis\tO\npresented\tO\nto\tO\nthe\tO\ntubular\tO\ncells\tO\n.\tO\n\nUrine\tO\nNAG\tO\nactivity\tO\nis\tO\nthus\tO\na\tO\nmeasure\tO\nof\tO\naltered\tO\nfunction\tO\nin\tO\nthe\tO\nrenal\tO\ntubules\tO\nand\tO\nnot\tO\nsimply\tO\nan\tO\nindicator\tO\nof\tO\ndamage\tO\n.\tO\n\nCauda\tB-Disease\nequina\tI-Disease\nsyndrome\tI-Disease\nafter\tO\nspinal\tO\nanaesthesia\tO\nwith\tO\nhyperbaric\tO\n5\tO\n%\tO\nlignocaine\tB-Chemical\n:\tO\na\tO\nreview\tO\nof\tO\nsix\tO\ncases\tO\nof\tO\ncauda\tB-Disease\nequina\tI-Disease\nsyndrome\tI-Disease\nreported\tO\nto\tO\nthe\tO\nSwedish\tO\nPharmaceutical\tO\nInsurance\tO\n1993\tO\n-\tO\n1997\tO\n.\tO\n\nSix\tO\ncases\tO\nof\tO\ncauda\tB-Disease\nequina\tI-Disease\nsyndrome\tI-Disease\nwith\tO\nvarying\tO\nseverity\tO\nwere\tO\nreported\tO\nto\tO\nthe\tO\nSwedish\tO\nPharmaceutical\tO\nInsurance\tO\nduring\tO\nthe\tO\nperiod\tO\n1993\tO\n-\tO\n1997\tO\n.\tO\n\nAll\tO\nwere\tO\nassociated\tO\nwith\tO\nspinal\tO\nanaesthesia\tO\nusing\tO\nhyperbaric\tO\n5\tO\n%\tO\nlignocaine\tB-Chemical\n.\tO\n\nFive\tO\ncases\tO\nhad\tO\nsingle\tO\n-\tO\nshot\tO\nspinal\tO\nanaesthesia\tO\nand\tO\none\tO\nhad\tO\na\tO\nrepeat\tO\nspinal\tO\nanaesthetic\tO\ndue\tO\nto\tO\ninadequate\tO\nblock\tO\n.\tO\n\nThe\tO\ndose\tO\nof\tO\nhyperbaric\tO\n5\tO\n%\tO\nlignocaine\tB-Chemical\nadministered\tO\nranged\tO\nfrom\tO\n60\tO\nto\tO\n120\tO\nmg\tO\n.\tO\n\nThree\tO\nof\tO\nthe\tO\ncases\tO\nwere\tO\nmost\tO\nlikely\tO\ncaused\tO\nby\tO\ndirect\tO\nneurotoxicity\tB-Disease\nof\tO\nhyperbaric\tO\n5\tO\n%\tO\nlignocaine\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\nother\tO\n3\tO\ncases\tO\n,\tO\ndirect\tO\nneurotoxicity\tB-Disease\nwas\tO\nalso\tO\nprobable\tO\n,\tO\nbut\tO\nunfortunately\tO\nradiological\tO\ninvestigations\tO\nwere\tO\nnot\tO\ndone\tO\nto\tO\ndefinitely\tO\nexclude\tO\na\tO\ncompressive\tO\naetiology\tO\n.\tO\n\nAll\tO\ncases\tO\nsustained\tO\npermanent\tO\nneurological\tB-Disease\ndeficits\tI-Disease\n.\tO\n\nWe\tO\nrecommend\tO\nthat\tO\nhyperbaric\tO\nlignocaine\tB-Chemical\nshould\tO\nbe\tO\nadministered\tO\nin\tO\nconcentrations\tO\nnot\tO\ngreater\tO\nthan\tO\n2\tO\n%\tO\nand\tO\nat\tO\na\tO\ntotal\tO\ndose\tO\npreferably\tO\nnot\tO\nexceeding\tO\n60\tO\nmg\tO\n.\tO\n\nSystemic\tO\ntoxicity\tB-Disease\nfollowing\tO\nadministration\tO\nof\tO\nsirolimus\tB-Chemical\n(\tO\nformerly\tO\nrapamycin\tB-Chemical\n)\tO\nfor\tO\npsoriasis\tB-Disease\n:\tO\nassociation\tO\nof\tO\ncapillary\tB-Disease\nleak\tI-Disease\nsyndrome\tI-Disease\nwith\tO\napoptosis\tO\nof\tO\nlesional\tO\nlymphocytes\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nSirolimus\tB-Chemical\n(\tO\nformerly\tO\nrapamycin\tB-Chemical\n)\tO\nis\tO\nan\tO\nimmunosuppressive\tO\nagent\tO\nthat\tO\ninterferes\tO\nwith\tO\nT\tO\n-\tO\ncell\tO\nactivation\tO\n.\tO\n\nAfter\tO\n2\tO\nindividuals\tO\nwith\tO\npsoriasis\tB-Disease\ndeveloped\tO\na\tO\ncapillary\tB-Disease\nleak\tI-Disease\nsyndrome\tI-Disease\nfollowing\tO\ntreatment\tO\nwith\tO\noral\tO\nsirolimus\tB-Chemical\nlesional\tO\nskin\tO\ncells\tO\nand\tO\nactivated\tO\nperipheral\tO\nblood\tO\ncells\tO\nwere\tO\nanalyzed\tO\nfor\tO\ninduction\tO\nof\tO\napoptosis\tO\n.\tO\n\nOBSERVATIONS\tO\n:\tO\nA\tO\nkeratome\tO\nskin\tO\nspecimen\tO\nfrom\tO\n1\tO\npatient\tO\nwith\tO\nsirolimus\tB-Chemical\n-\tO\ninduced\tO\ncapillary\tB-Disease\nleak\tI-Disease\nsyndrome\tI-Disease\nhad\tO\na\tO\n2\tO\n.\tO\n3\tO\n-\tO\nfold\tO\nincrease\tO\nin\tO\npercentage\tO\nof\tO\napoptotic\tO\ncells\tO\n(\tO\nto\tO\n48\tO\n%\tO\n)\tO\ncompared\tO\nwith\tO\nan\tO\nunaffected\tO\nsirolimus\tB-Chemical\n-\tO\ntreated\tO\npatient\tO\nwith\tO\npsoriasis\tB-Disease\n(\tO\n21\tO\n%\tO\n)\tO\n.\tO\n\nActivated\tO\nperipheral\tO\nblood\tO\nT\tO\ncells\tO\nfrom\tO\npatients\tO\nwith\tO\npsoriasis\tB-Disease\ntended\tO\nto\tO\nexhibit\tO\ngreater\tO\nspontaneous\tO\nor\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\napoptosis\tO\nthan\tO\ndid\tO\nnormal\tO\nT\tO\ncells\tO\n,\tO\nparticularly\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nsirolimus\tB-Chemical\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSevere\tO\nadverse\tO\neffects\tO\nof\tO\nsirolimus\tB-Chemical\ninclude\tO\nfever\tB-Disease\n,\tO\nanemia\tB-Disease\n,\tO\nand\tO\ncapillary\tB-Disease\nleak\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nThese\tO\nsymptoms\tO\nmay\tO\nbe\tO\nthe\tO\nresult\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\napoptosis\tO\nof\tO\nlesional\tO\nleukocytes\tO\n,\tO\nespecially\tO\nactivated\tO\nT\tO\nlymphocytes\tO\n,\tO\nand\tO\npossibly\tO\nrelease\tO\nof\tO\ninflammatory\tO\nmediators\tO\n.\tO\n\nBecause\tO\npatients\tO\nwith\tO\nsevere\tO\npsoriasis\tB-Disease\nmay\tO\ndevelop\tO\ncapillary\tB-Disease\nleak\tI-Disease\nfrom\tO\nvarious\tO\nsystemic\tO\ntherapies\tO\n,\tO\nclinical\tO\nmonitoring\tO\nis\tO\nadvisable\tO\nfor\tO\npatients\tO\nwith\tO\ninflammatory\tB-Disease\ndiseases\tI-Disease\nwho\tO\nare\tO\ntreated\tO\nwith\tO\nimmune\tO\nmodulators\tO\n.\tO\n\nEffect\tO\nof\tO\nlithium\tB-Chemical\nmaintenance\tO\ntherapy\tO\non\tO\nthyroid\tO\nand\tO\nparathyroid\tO\nfunction\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nassess\tO\nchanges\tO\ninduced\tO\nby\tO\nlithium\tB-Chemical\nmaintenance\tO\ntherapy\tO\non\tO\nthe\tO\nincidence\tO\nof\tO\nthyroid\tO\n,\tO\nparathyroid\tO\nand\tO\nion\tO\nalterations\tO\n.\tO\n\nThese\tO\nwere\tO\nevaluated\tO\nwith\tO\nrespect\tO\nto\tO\nthe\tO\nduration\tO\nof\tO\nlithium\tB-Chemical\ntherapy\tO\n,\tO\nage\tO\n,\tO\nsex\tO\n,\tO\nand\tO\nfamily\tO\nhistory\tO\n(\tO\nwhether\tO\nor\tO\nnot\tO\nthe\tO\npatient\tO\nhad\tO\na\tO\nfirst\tO\n-\tO\ndegree\tO\nrelative\tO\nwith\tO\nthyroid\tB-Disease\ndisease\tI-Disease\n)\tO\n.\tO\n\nDESIGN\tO\n:\tO\nProspective\tO\nstudy\tO\n.\tO\n\nSETTING\tO\n:\tO\nAffective\tO\nDisorders\tO\nClinic\tO\nat\tO\nSt\tO\n.\tO\n\nMary\tO\n'\tO\ns\tO\nHospital\tO\n,\tO\nMontreal\tO\n.\tO\n\nPATIENTS\tO\n:\tO\nOne\tO\nhundred\tO\nand\tO\none\tO\npatients\tO\n(\tO\n28\tO\nmen\tO\nand\tO\n73\tO\nwomen\tO\n)\tO\nwith\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\nreceiving\tO\nlithium\tB-Chemical\nmaintenance\tO\ntherapy\tO\nranging\tO\nfrom\tO\n1\tO\nyear\tO\n'\tO\ns\tO\nto\tO\n32\tO\nyears\tO\n'\tO\nduration\tO\n.\tO\n\nThe\tO\ncontrol\tO\ngroup\tO\nconsisted\tO\nof\tO\n82\tO\npatients\tO\nwith\tO\nno\tO\npsychiatric\tB-Disease\nor\tO\nendocrinological\tO\ndiagnoses\tO\nfrom\tO\nthe\tO\nhospital\tO\n'\tO\ns\tO\nout\tO\n-\tO\npatient\tO\nclinics\tO\n.\tO\n\nOUTCOME\tO\nMEASURES\tO\n:\tO\nLaboratory\tO\nanalyses\tO\nof\tO\ncalcium\tB-Chemical\n,\tO\nmagnesium\tB-Chemical\nand\tO\nthyroid\tO\n-\tO\nstimulating\tO\nhormone\tO\nlevels\tO\nperformed\tO\nbefore\tO\nbeginning\tO\nlithium\tB-Chemical\ntherapy\tO\nand\tO\nat\tO\nbiannual\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHypothyroidism\tB-Disease\ndeveloped\tO\nin\tO\n40\tO\npatients\tO\n,\tO\nexcluding\tO\n8\tO\npatients\tO\nwho\tO\nwere\tO\nhypothyroid\tB-Disease\nat\tO\nbaseline\tO\n.\tO\n\nAll\tO\npatients\tO\nhaving\tO\nfirst\tO\n-\tO\ndegree\tO\nrelatives\tO\naffected\tO\nby\tO\nthyroid\tB-Disease\nillness\tI-Disease\nhad\tO\naccelerated\tO\nonset\tO\nof\tO\nhypothyroidism\tB-Disease\n(\tO\n3\tO\n.\tO\n7\tO\nyears\tO\nafter\tO\nonset\tO\nof\tO\nlithium\tB-Chemical\ntherapy\tO\n)\tO\ncompared\tO\nwith\tO\npatients\tO\nwithout\tO\na\tO\nfamily\tO\nhistory\tO\n(\tO\n8\tO\n.\tO\n6\tO\nyears\tO\nafter\tO\nonset\tO\nof\tO\nlithium\tB-Chemical\ntherapy\tO\n)\tO\n.\tO\n\nWomen\tO\nover\tO\n60\tO\nyears\tO\nof\tO\nage\tO\nwere\tO\nmore\tO\noften\tO\naffected\tO\nby\tO\nhypothyroidism\tB-Disease\nthan\tO\nwomen\tO\nunder\tO\n60\tO\nyears\tO\nof\tO\nage\tO\n(\tO\n34\tO\n.\tO\n6\tO\n%\tO\nversus\tO\n31\tO\n.\tO\n9\tO\n%\tO\n)\tO\n.\tO\n\nMagnesium\tB-Chemical\nlevels\tO\nin\tO\npatients\tO\non\tO\nlithium\tB-Chemical\ntreatment\tO\nwere\tO\nunchanged\tO\nfrom\tO\nbaseline\tO\nlevels\tO\n.\tO\n\nAfter\tO\nlithium\tB-Chemical\ntreatment\tO\n,\tO\ncalcium\tB-Chemical\nlevels\tO\nwere\tO\nhigher\tO\nthan\tO\neither\tO\nbaseline\tO\nlevels\tO\nor\tO\ncontrol\tO\nlevels\tO\n.\tO\n\nThus\tO\n,\tO\nlithium\tB-Chemical\ntreatment\tO\ncounteracted\tO\nthe\tO\ndecrease\tO\nin\tO\nplasma\tO\ncalcium\tB-Chemical\nlevels\tO\nassociated\tO\nwith\tO\naging\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nFamilial\tO\nthyroid\tB-Disease\nillness\tI-Disease\nis\tO\na\tO\nrisk\tO\nfactor\tO\nfor\tO\nhypothyroidism\tB-Disease\nand\tO\nhypercalcemia\tB-Disease\nduring\tO\nlithium\tB-Chemical\ntherapy\tO\n.\tO\n\nSevere\tO\nimmune\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nassociated\tO\nwith\tO\nprophylactic\tO\nuse\tO\nof\tO\ncefotetan\tB-Chemical\nin\tO\nobstetric\tO\nand\tO\ngynecologic\tO\nprocedures\tO\n.\tO\n\nSecond\tO\n-\tO\nand\tO\nthird\tO\n-\tO\ngeneration\tO\ncephalosporins\tB-Chemical\n,\tO\nespecially\tO\ncefotetan\tB-Chemical\n,\tO\nare\tO\nincreasingly\tO\nassociated\tO\nwith\tO\nsevere\tO\n,\tO\nsometimes\tO\nfatal\tO\nimmune\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nWe\tO\nnoticed\tO\nthat\tO\n10\tO\nof\tO\nour\tO\n35\tO\ncases\tO\nof\tO\ncefotetan\tB-Chemical\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemias\tI-Disease\nwere\tO\nin\tO\npatients\tO\nwho\tO\nhad\tO\nreceived\tO\ncefotetan\tB-Chemical\nprophylactically\tO\nfor\tO\nobstetric\tO\nand\tO\ngynecologic\tO\nprocedures\tO\n.\tO\n\nEight\tO\nof\tO\nthese\tO\ncases\tO\nof\tO\nsevere\tO\nimmune\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nare\tO\ndescribed\tO\n.\tO\n\nEffects\tO\nof\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\non\tO\nhemostasis\tO\nin\tO\npatients\tO\nwith\tO\naneurysmal\tB-Disease\nsubarachnoid\tI-Disease\nhemorrhage\tI-Disease\n.\tO\n\nPlatelet\tO\nfunction\tO\nis\tO\nimpaired\tO\nby\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\n(\tO\nNSAIDs\tO\n)\tO\nwith\tO\nprominent\tO\nanti\tO\n-\tO\ninflammatory\tO\nproperties\tO\n.\tO\n\nTheir\tO\nsafety\tO\nin\tO\npatients\tO\nundergoing\tO\nintracranial\tO\nsurgery\tO\nis\tO\nunder\tO\ndebate\tO\n.\tO\n\nPatients\tO\nwith\tO\naneurysmal\tB-Disease\nsubarachnoid\tI-Disease\nhemorrhage\tI-Disease\n(\tO\nSAH\tB-Disease\n)\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\neither\tO\nketoprofen\tB-Chemical\n,\tO\n100\tO\nmg\tO\n,\tO\nthree\tO\ntimes\tO\na\tO\nday\tO\n(\tO\nketoprofen\tB-Chemical\ngroup\tO\n,\tO\nn\tO\n=\tO\n9\tO\n)\tO\nor\tO\na\tO\nweak\tO\nNSAID\tO\n,\tO\nacetaminophen\tB-Chemical\n,\tO\n1\tO\ng\tO\n,\tO\nthree\tO\ntimes\tO\na\tO\nday\tO\n(\tO\nacetaminophen\tB-Chemical\ngroup\tO\n,\tO\nn\tO\n=\tO\n9\tO\n)\tO\nstarting\tO\nimmediately\tO\nafter\tO\nthe\tO\ndiagnosis\tO\nof\tO\naneurysmal\tB-Disease\nSAH\tB-Disease\n.\tO\n\nTreatment\tO\nwas\tO\ncontinued\tO\nfor\tO\n3\tO\ndays\tO\npostoperatively\tO\n.\tO\n\nTest\tO\nblood\tO\nsamples\tO\nwere\tO\ntaken\tO\nbefore\tO\ntreatment\tO\nand\tO\nsurgery\tO\nas\tO\nwell\tO\nas\tO\non\tO\nthe\tO\nfirst\tO\n,\tO\nthird\tO\n,\tO\nand\tO\nfifth\tO\npostoperative\tO\nmornings\tO\n.\tO\n\nMaximal\tO\nplatelet\tB-Disease\naggregation\tI-Disease\ninduced\tO\nby\tO\n6\tO\nmicroM\tO\nof\tO\nadenosine\tB-Chemical\ndiphosphate\tI-Chemical\ndecreased\tO\nafter\tO\nadministration\tO\nof\tO\nketoprofen\tB-Chemical\n.\tO\n\nAggregation\tO\nwas\tO\nlower\tO\n(\tO\nP\tO\n<\tO\n.\tO\n05\tO\n)\tO\nin\tO\nthe\tO\nketoprofen\tB-Chemical\ngroup\tO\nthan\tO\nin\tO\nthe\tO\nacetaminophen\tB-Chemical\ngroup\tO\njust\tO\nbefore\tO\nsurgery\tO\nand\tO\non\tO\nthe\tO\nthird\tO\npostoperative\tO\nday\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nmaximal\tO\nplatelet\tB-Disease\naggregation\tI-Disease\nincreased\tO\nin\tO\nthe\tO\nacetaminophen\tB-Chemical\ngroup\tO\non\tO\nthe\tO\nthird\tO\npostoperative\tO\nday\tO\nas\tO\ncompared\tO\nwith\tO\nthe\tO\npretreatment\tO\nplatelet\tB-Disease\naggregation\tI-Disease\nresults\tO\n(\tO\nP\tO\n<\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nOne\tO\npatient\tO\nin\tO\nthe\tO\nketoprofen\tB-Chemical\ngroup\tO\ndeveloped\tO\na\tO\npostoperative\tO\nintracranial\tO\nhematoma\tB-Disease\n.\tO\n\nCoagulation\tO\n(\tO\nprothrombin\tO\ntime\tO\n[\tO\nPT\tO\n]\tO\n,\tO\nactivated\tO\npartial\tO\nthromboplastin\tO\ntime\tO\n[\tO\nAPPT\tO\n]\tO\n,\tO\nfibrinogen\tO\nconcentration\tO\n,\tO\nand\tO\nantithrombin\tO\nIII\tO\n[\tO\nAT\tO\nIII\tO\n]\tO\n)\tO\nwas\tO\ncomparable\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nKetoprofen\tB-Chemical\nbut\tO\nnot\tO\nacetaminophen\tB-Chemical\nimpaired\tO\nplatelet\tO\nfunction\tO\nin\tO\npatients\tO\nwith\tO\nSAH\tB-Disease\n.\tO\n\nIf\tO\nketoprofen\tB-Chemical\nis\tO\nused\tO\nbefore\tO\nsurgery\tO\non\tO\ncerebral\tO\nartery\tB-Disease\naneurysms\tI-Disease\n,\tO\nit\tO\nmay\tO\npose\tO\nan\tO\nadditional\tO\nrisk\tO\nfactor\tO\nfor\tO\nhemorrhage\tB-Disease\n.\tO\n\nNitric\tB-Chemical\noxide\tI-Chemical\nsynthase\tO\nexpression\tO\nin\tO\nthe\tO\ncourse\tO\nof\tO\nlead\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n.\tO\n\nWe\tO\nrecently\tO\nshowed\tO\nelevated\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\n(\tO\nROS\tO\n)\tO\n,\tO\nreduced\tO\nurinary\tO\nexcretion\tO\nof\tO\nNO\tB-Chemical\nmetabolites\tO\n(\tO\nNOx\tO\n)\tO\n,\tO\nand\tO\nincreased\tO\nNO\tB-Chemical\nsequestration\tO\nas\tO\nnitrotyrosine\tB-Chemical\nin\tO\nvarious\tO\ntissues\tO\nin\tO\nrats\tO\nwith\tO\nlead\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\ndiscern\tO\nwhether\tO\nthe\tO\nreduction\tO\nin\tO\nurinary\tO\nNOx\tO\nin\tO\nlead\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nis\tO\n,\tO\nin\tO\npart\tO\n,\tO\ndue\tO\nto\tO\ndepressed\tO\nNO\tB-Chemical\nsynthase\tO\n(\tO\nNOS\tO\n)\tO\nexpression\tO\n.\tO\n\nMale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\na\tO\nlead\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\n(\tO\ngiven\tO\nlead\tB-Chemical\nacetate\tI-Chemical\n,\tO\n100\tO\nppm\tO\n,\tO\nin\tO\ndrinking\tO\nwater\tO\nand\tO\nregular\tO\nrat\tO\nchow\tO\n)\tO\n,\tO\na\tO\ngroup\tO\ngiven\tO\nlead\tB-Chemical\nand\tO\nvitamin\tB-Chemical\nE\tI-Chemical\n-\tO\nfortified\tO\nchow\tO\n,\tO\nor\tO\na\tO\nnormal\tO\ncontrol\tO\ngroup\tO\ngiven\tO\neither\tO\nregular\tO\nfood\tO\nand\tO\nwater\tO\nor\tO\nvitamin\tB-Chemical\nE\tI-Chemical\n-\tO\nfortified\tO\nfood\tO\nfor\tO\n12\tO\nweeks\tO\n.\tO\n\nTail\tO\nblood\tO\npressure\tO\n,\tO\nurinary\tO\nNOx\tO\nexcretion\tO\n,\tO\nplasma\tO\nmalondialdehyde\tB-Chemical\n(\tO\nMDA\tB-Chemical\n)\tO\n,\tO\nand\tO\nendothelial\tO\nand\tO\ninducible\tO\nNOS\tO\n(\tO\neNOS\tO\nand\tO\niNOS\tO\n)\tO\nisotypes\tO\nin\tO\nthe\tO\naorta\tO\nand\tO\nkidney\tO\nwere\tO\nmeasured\tO\n.\tO\n\nThe\tO\nlead\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\nexhibited\tO\na\tO\nrise\tO\nin\tO\nblood\tO\npressure\tO\nand\tO\nplasma\tO\nMDA\tB-Chemical\nconcentration\tO\n,\tO\na\tO\nfall\tO\nin\tO\nurinary\tO\nNOx\tO\nexcretion\tO\n,\tO\nand\tO\na\tO\nparadoxical\tO\nrise\tO\nin\tO\nvascular\tO\nand\tO\nrenal\tO\ntissue\tO\neNOS\tO\nand\tO\niNOS\tO\nexpression\tO\n.\tO\n\nVitamin\tB-Chemical\nE\tI-Chemical\nsupplementation\tO\nameliorated\tO\nhypertension\tB-Disease\n,\tO\nlowered\tO\nplasma\tO\nMDA\tB-Chemical\nconcentration\tO\n,\tO\nand\tO\nraised\tO\nurinary\tO\nNOx\tO\nexcretion\tO\nwhile\tO\nsignificantly\tO\nlowering\tO\nvascular\tO\n,\tO\nbut\tO\nnot\tO\nrenal\tO\n,\tO\ntissue\tO\neNOS\tO\nand\tO\niNOS\tO\nexpression\tO\n.\tO\n\nVitamin\tB-Chemical\nE\tI-Chemical\nsupplementation\tO\nhad\tO\nno\tO\neffect\tO\non\tO\neither\tO\nblood\tO\npressure\tO\n,\tO\nplasma\tO\nMDA\tB-Chemical\n,\tO\nor\tO\nNOS\tO\nexpression\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nThe\tO\nstudy\tO\nalso\tO\nrevealed\tO\nsignificant\tO\ninhibition\tO\nof\tO\nNOS\tO\nenzymatic\tO\nactivity\tO\nby\tO\nlead\tB-Chemical\nin\tO\ncell\tO\n-\tO\nfree\tO\npreparations\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nlead\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nthis\tO\nmodel\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\ncompensatory\tO\nupregulation\tO\nof\tO\nrenal\tO\nand\tO\nvascular\tO\neNOS\tO\nand\tO\niNOS\tO\nexpression\tO\n.\tO\n\nThis\tO\nis\tO\n,\tO\nin\tO\npart\tO\n,\tO\ndue\tO\nto\tO\nROS\tO\n-\tO\nmediated\tO\nNO\tB-Chemical\ninactivation\tO\n,\tO\nlead\tB-Chemical\n-\tO\nassociated\tO\ninhibition\tO\nof\tO\nNOS\tO\nactivity\tO\n,\tO\nand\tO\nperhaps\tO\nstimulatory\tO\nactions\tO\nof\tO\nincreased\tO\nshear\tO\nstress\tO\nassociated\tO\nwith\tO\nhypertension\tB-Disease\n.\tO\n\nGlyceryl\tB-Chemical\ntrinitrate\tI-Chemical\ninduces\tO\nattacks\tO\nof\tO\nmigraine\tB-Disease\nwithout\tI-Disease\naura\tI-Disease\nin\tO\nsufferers\tO\nof\tO\nmigraine\tB-Disease\nwith\tI-Disease\naura\tI-Disease\n.\tO\n\nMigraine\tB-Disease\nwith\tI-Disease\naura\tI-Disease\nand\tO\nmigraine\tB-Disease\nwithout\tI-Disease\naura\tI-Disease\nhave\tO\nthe\tO\nsame\tO\npain\tB-Disease\nphase\tO\n,\tO\nthus\tO\nindicating\tO\nthat\tO\nmigraine\tB-Disease\nwith\tI-Disease\naura\tI-Disease\nand\tO\nmigraine\tB-Disease\nwithout\tI-Disease\naura\tI-Disease\nshare\tO\na\tO\ncommon\tO\npathway\tO\nof\tO\nnociception\tO\n.\tO\n\nIn\tO\nrecent\tO\nyears\tO\n,\tO\nincreasing\tO\nevidence\tO\nhas\tO\nsuggested\tO\nthat\tO\nthe\tO\nmessenger\tO\nmolecule\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\nis\tO\ninvolved\tO\nin\tO\npain\tB-Disease\nmechanisms\tO\nof\tO\nmigraine\tB-Disease\nwithout\tI-Disease\naura\tI-Disease\n.\tO\n\nIn\tO\norder\tO\nto\tO\nclarify\tO\nwhether\tO\nthe\tO\nsame\tO\nis\tO\ntrue\tO\nfor\tO\nmigraine\tB-Disease\nwith\tI-Disease\naura\tI-Disease\n,\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\nwe\tO\nexamined\tO\nthe\tO\nheadache\tB-Disease\nresponse\tO\nto\tO\nintravenous\tO\ninfusion\tO\nof\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\n(\tO\nGTN\tB-Chemical\n)\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmicrog\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\nfor\tO\n20\tO\nmin\tO\n)\tO\nin\tO\n12\tO\nsufferers\tO\nof\tO\nmigraine\tB-Disease\nwith\tI-Disease\naura\tI-Disease\n.\tO\n\nThe\tO\nspecific\tO\naim\tO\nwas\tO\nto\tO\nelucidate\tO\nwhether\tO\nan\tO\naura\tO\nand\tO\n/\tO\nor\tO\nan\tO\nattack\tO\nof\tO\nmigraine\tB-Disease\nwithout\tI-Disease\naura\tI-Disease\ncould\tO\nbe\tO\ninduced\tO\n.\tO\n\nFourteen\tO\nhealthy\tO\nsubjects\tO\nserved\tO\nas\tO\ncontrols\tO\n.\tO\n\nAura\tO\nsymptoms\tO\nwere\tO\nnot\tO\nelicited\tO\nin\tO\nany\tO\nsubject\tO\n.\tO\n\nHeadache\tB-Disease\nwas\tO\nmore\tO\nsevere\tO\nin\tO\nmigraineurs\tB-Disease\nthan\tO\nin\tO\nthe\tO\ncontrols\tO\nduring\tO\nand\tO\nimmediately\tO\nafter\tO\nGTN\tB-Chemical\ninfusion\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n037\tO\n)\tO\nas\tO\nwell\tO\nas\tO\nduring\tO\nthe\tO\nfollowing\tO\n11\tO\nh\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n008\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\ncontrols\tO\n,\tO\nthe\tO\nGTN\tB-Chemical\n-\tO\ninduced\tO\nheadache\tB-Disease\ngradually\tO\ndisappeared\tO\n,\tO\nwhereas\tO\nin\tO\nmigraineurs\tB-Disease\npeak\tO\nheadache\tB-Disease\nintensity\tO\noccurred\tO\nat\tO\na\tO\nmean\tO\ntime\tO\nof\tO\n240\tO\nmin\tO\npost\tO\n-\tO\ninfusion\tO\n.\tO\n\nAt\tO\nthis\tO\ntime\tO\nthe\tO\ninduced\tO\nheadache\tB-Disease\nin\tO\n6\tO\nof\tO\n12\tO\nmigraineurs\tB-Disease\nfulfilled\tO\nthe\tO\ndiagnostic\tO\ncriteria\tO\nfor\tO\nmigraine\tB-Disease\nwithout\tI-Disease\naura\tI-Disease\nof\tO\nthe\tO\nInternational\tO\nHeadache\tB-Disease\nSociety\tO\n.\tO\n\nThe\tO\nresults\tO\ntherefore\tO\nsuggest\tO\nthat\tO\nNO\tB-Chemical\nis\tO\ninvolved\tO\nin\tO\nthe\tO\npain\tB-Disease\nmechanisms\tO\nof\tO\nmigraine\tB-Disease\nwith\tI-Disease\naura\tI-Disease\n.\tO\n\nSince\tO\ncortical\tO\nspreading\tO\ndepression\tB-Disease\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nliberate\tO\nNO\tB-Chemical\nin\tO\nanimals\tO\n,\tO\nthis\tO\nfinding\tO\nmay\tO\nhelp\tO\nour\tO\nunderstanding\tO\nof\tO\nthe\tO\ncoupling\tO\nbetween\tO\ncortical\tO\nspreading\tO\ndepression\tB-Disease\nand\tO\nheadache\tB-Disease\nin\tO\nmigraine\tB-Disease\nwith\tI-Disease\naura\tI-Disease\n.\tO\n\nRapid\tO\nreversal\tO\nof\tO\nlife\tO\n-\tO\nthreatening\tO\ndiltiazem\tB-Chemical\n-\tO\ninduced\tO\ntetany\tB-Disease\nwith\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\npatient\tO\nwho\tO\ndeveloped\tO\ntetany\tB-Disease\nwith\tO\nsudden\tO\nrespiratory\tB-Disease\narrest\tI-Disease\nafter\tO\nthe\tO\ninfusion\tO\nof\tO\nintravenous\tO\ndiltiazem\tB-Chemical\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\nrapidly\tO\nresolved\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\ntetany\tB-Disease\nwith\tO\nprompt\tO\nrecovery\tO\nof\tO\nrespiratory\tO\nfunction\tO\n,\tO\naverting\tO\nthe\tO\nneed\tO\nfor\tO\nmore\tO\naggressive\tO\nairway\tO\nmanagement\tO\nand\tO\nventilatory\tO\nsupport\tO\n.\tO\n\nThe\tO\nemergency\tO\nphysician\tO\nshould\tO\nbe\tO\naware\tO\nthat\tO\nlife\tO\n-\tO\nthreatening\tO\ntetany\tB-Disease\nmay\tO\naccompany\tO\nthe\tO\nadministration\tO\nof\tO\nintravenous\tO\ndiltiazem\tB-Chemical\nand\tO\nthat\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\nmay\tO\nbe\tO\na\tO\nrapid\tO\nand\tO\neffective\tO\nremedy\tO\n.\tO\n\nPredictors\tO\nof\tO\ndecreased\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nin\tO\npatients\tO\nwith\tO\nheart\tB-Disease\nfailure\tI-Disease\nduring\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\ntherapy\tO\n:\tO\nresults\tO\nfrom\tO\nthe\tO\nstudies\tO\nof\tO\nleft\tB-Disease\nventricular\tI-Disease\ndysfunction\tI-Disease\n(\tO\nSOLVD\tO\n)\tO\n\nBACKGROUND\tO\n:\tO\nAlthough\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\ntherapy\tO\nreduces\tO\nmortality\tO\nrates\tO\nin\tO\npatients\tO\nwith\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n(\tO\nCHF\tB-Disease\n)\tO\n,\tO\nit\tO\nmay\tO\nalso\tO\ncause\tO\ndecreased\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\n.\tO\n\nLittle\tO\ninformation\tO\nis\tO\navailable\tO\nto\tO\npredict\tO\nwhich\tO\npatients\tO\nare\tO\nat\tO\nhighest\tO\nrisk\tO\nfor\tO\nthis\tO\ncomplication\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nquantify\tO\nspecific\tO\nclinical\tO\npredictors\tO\nof\tO\nreduction\tB-Disease\nin\tI-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nin\tO\npatients\tO\nwith\tO\nCHF\tB-Disease\nwho\tO\nare\tO\nprescribed\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\ntherapy\tO\n.\tO\n\nMETHOD\tO\n:\tO\nWe\tO\nanalyzed\tO\ndata\tO\nfrom\tO\nthe\tO\nStudies\tO\nof\tO\nLeft\tB-Disease\nVentricular\tI-Disease\nDysfunction\tI-Disease\n(\tO\nSOLVD\tO\n)\tO\n,\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrial\tO\nof\tO\nenalapril\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nCHF\tB-Disease\n.\tO\n\nThere\tO\nwere\tO\n3379\tO\npatients\tO\nrandomly\tO\nassigned\tO\nto\tO\nenalapril\tB-Chemical\nwith\tO\na\tO\nmedian\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n974\tO\ndays\tO\nand\tO\n3379\tO\npatients\tO\nrandomly\tO\nassigned\tO\nto\tO\nplacebo\tO\nwith\tO\na\tO\nmean\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n967\tO\ndays\tO\n.\tO\n\nDecreased\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nwas\tO\ndefined\tO\nas\tO\na\tO\nrise\tO\nin\tO\nserum\tO\ncreatinine\tB-Chemical\n>\tO\n/\tO\n=\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndL\tO\n(\tO\n44\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nfrom\tO\nbaseline\tO\n.\tO\n\nWe\tO\nused\tO\ntime\tO\n-\tO\nto\tO\n-\tO\nevent\tO\nanalysis\tO\nto\tO\nidentify\tO\npotential\tO\npredictors\tO\nof\tO\ndecrease\tO\nin\tO\nrenal\tO\nfunction\tO\nincluding\tO\nage\tO\n,\tO\nbaseline\tO\nejection\tO\nfraction\tO\n,\tO\nbaseline\tO\ncreatinine\tB-Chemical\n,\tO\nlow\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\n<\tO\n100\tO\nmm\tO\nHg\tO\n)\tO\n,\tO\nhistory\tO\nof\tO\nhypertension\tB-Disease\n,\tO\ndiabetes\tB-Disease\n,\tO\nand\tO\nuse\tO\nof\tO\nantiplatelet\tO\n,\tO\ndiuretic\tB-Chemical\n,\tO\nand\tO\nbeta\tO\n-\tO\nblocker\tO\ntherapy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nPatients\tO\nrandomly\tO\nassigned\tO\nto\tO\nenalapril\tB-Chemical\nhad\tO\na\tO\n33\tO\n%\tO\ngreater\tO\nlikelihood\tO\nof\tO\ndecreased\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nthan\tO\ncontrols\tO\n(\tO\nP\tO\n=\tO\n.\tO\n003\tO\n)\tO\n.\tO\n\nBy\tO\nmultivariate\tO\nanalysis\tO\n,\tO\nin\tO\nboth\tO\nthe\tO\nplacebo\tO\nand\tO\nenalapril\tB-Chemical\ngroups\tO\nolder\tO\nage\tO\n,\tO\ndiuretic\tB-Chemical\ntherapy\tO\n,\tO\nand\tO\ndiabetes\tB-Disease\nwere\tO\nassociated\tO\nwith\tO\ndecreased\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\n,\tO\nwhereas\tO\nbeta\tO\n-\tO\nblocker\tO\ntherapy\tO\nand\tO\nhigher\tO\nejection\tO\nfraction\tO\nwere\tO\nrenoprotective\tO\n.\tO\n\nOlder\tO\nage\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\ngreater\tO\nrisk\tO\nof\tO\ndeveloping\tO\ndecreased\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nin\tO\nboth\tO\ngroups\tO\n,\tO\nbut\tO\nsignificantly\tO\nmore\tO\nso\tO\nin\tO\nthe\tO\nenalapril\tB-Chemical\ngroup\tO\n(\tO\nenalapril\tB-Chemical\n:\tO\nrisk\tO\nratio\tO\n[\tO\nRR\tO\n]\tO\n1\tO\n.\tO\n42\tO\nper\tO\n10\tO\nyears\tO\n,\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n1\tO\n.\tO\n32\tO\n-\tO\n1\tO\n.\tO\n52\tO\nwith\tO\nenalapril\tB-Chemical\n;\tO\nplacebo\tO\n:\tO\nRR\tO\n1\tO\n.\tO\n18\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n12\tO\n-\tO\n1\tO\n.\tO\n25\tO\n)\tO\n.\tO\n\nDiuretic\tB-Chemical\ntherapy\tO\nwas\tO\nlikewise\tO\nassociated\tO\nwith\tO\na\tO\ngreater\tO\nrisk\tO\nof\tO\ndecreased\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nin\tO\nthe\tO\nenalapril\tB-Chemical\ngroup\tO\n(\tO\nRR\tO\n1\tO\n.\tO\n89\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n70\tO\n-\tO\n2\tO\n.\tO\n08\tO\n)\tO\nthan\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\n(\tO\nRR\tO\n1\tO\n.\tO\n35\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n09\tO\n-\tO\n1\tO\n.\tO\n66\tO\n)\tO\n.\tO\n\nConversely\tO\n,\tO\nenalapril\tB-Chemical\nhad\tO\na\tO\nrelative\tO\nrenoprotective\tO\neffect\tO\n(\tO\nRR\tO\n1\tO\n.\tO\n33\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n13\tO\n-\tO\n1\tO\n.\tO\n53\tO\n)\tO\ncompared\tO\nwith\tO\nplacebo\tO\n(\tO\nRR\tO\n1\tO\n.\tO\n96\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n57\tO\n-\tO\n2\tO\n.\tO\n44\tO\n)\tO\nin\tO\npatients\tO\nwith\tO\ndiabetes\tB-Disease\n.\tO\n\nA\tO\nlower\tO\nrisk\tO\nof\tO\nrenal\tB-Disease\nimpairment\tI-Disease\nwas\tO\nseen\tO\nin\tO\nboth\tO\ngroups\tO\nwith\tO\nbeta\tO\n-\tO\nblocker\tO\ntherapy\tO\n(\tO\nRR\tO\n0\tO\n.\tO\n70\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n57\tO\n-\tO\n0\tO\n.\tO\n85\tO\n)\tO\nand\tO\nhigher\tO\nbaseline\tO\nejection\tO\nfraction\tO\n(\tO\nRR\tO\n0\tO\n.\tO\n93\tO\nper\tO\n5\tO\n%\tO\nincrement\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n91\tO\n-\tO\n0\tO\n.\tO\n96\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nEnalapril\tB-Chemical\nuse\tO\ncaused\tO\na\tO\n33\tO\n%\tO\nincrease\tO\nin\tO\nthe\tO\nrisk\tO\nof\tO\ndecreased\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nin\tO\npatients\tO\nwith\tO\nCHF\tB-Disease\n.\tO\n\nDiuretic\tB-Chemical\nuse\tO\nand\tO\nadvanced\tO\nage\tO\nincreased\tO\nthis\tO\nrisk\tO\n.\tO\n\nDiabetes\tB-Disease\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nrenal\tB-Disease\nimpairment\tI-Disease\nin\tO\nall\tO\npatients\tO\nwith\tO\nCHF\tB-Disease\n,\tO\nbut\tO\nthis\tO\nrisk\tO\nwas\tO\nreduced\tO\nin\tO\nthe\tO\nenalapril\tB-Chemical\ngroup\tO\ncompared\tO\nwith\tO\nthe\tO\nplacebo\tO\ngroup\tO\n.\tO\n\nbeta\tO\n-\tO\nBlocker\tO\ntherapy\tO\nand\tO\nhigher\tO\nejection\tO\nfraction\tO\nwere\tO\nrenoprotective\tO\nin\tO\nall\tO\npatients\tO\nregardless\tO\nof\tO\ntherapy\tO\n.\tO\n\nHypomania\tB-Disease\n-\tO\nlike\tO\nsyndrome\tO\ninduced\tO\nby\tO\nolanzapine\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\nfemale\tO\npatient\tO\nwith\tO\na\tO\ndiagnosis\tO\nof\tO\na\tO\nnot\tO\notherwise\tO\nspecified\tO\npsychotic\tB-Disease\ndisorder\tI-Disease\n(\tO\nDSM\tO\n-\tO\nIV\tO\n)\tO\nwho\tO\ndeveloped\tO\nhypomania\tB-Disease\nshortly\tO\nafter\tO\nthe\tO\nintroduction\tO\nof\tO\nolanzapine\tB-Chemical\ntreatment\tO\n.\tO\n\nAcetazolamide\tB-Chemical\n-\tO\ninduced\tO\nGerstmann\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nAcute\tO\nconfusion\tB-Disease\ninduced\tO\nby\tO\nacetazolamide\tB-Chemical\nis\tO\na\tO\nwell\tO\nknown\tO\nadverse\tO\ndrug\tO\nreaction\tO\nin\tO\npatients\tO\nwith\tO\nrenal\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nacetazolamide\tB-Chemical\n-\tO\ninduced\tO\nGerstmann\tB-Disease\nsyndrome\tI-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nnormal\tO\nrenal\tO\nfunction\tO\n,\tO\nto\tO\nhighlight\tO\npredisposing\tO\nfactors\tO\nthat\tO\nare\tO\nfrequently\tO\noverlooked\tO\n.\tO\n\nVasopressin\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nmilrinone\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nin\tO\nsevere\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nThe\tO\nuse\tO\nof\tO\nphosphodiesterase\tO\ninhibitors\tO\nsuch\tO\nas\tO\nmilrinone\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nsevere\tO\nheart\tB-Disease\nfailure\tI-Disease\nis\tO\nfrequently\tO\nrestricted\tO\nbecause\tO\nthey\tO\ncause\tO\nvasodilation\tO\nand\tO\nhypotension\tB-Disease\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\ndecompensated\tO\nheart\tB-Disease\nfailure\tI-Disease\nwith\tO\nhypotension\tB-Disease\nafter\tO\ntreatment\tO\nwith\tO\nmilrinone\tB-Chemical\n,\tO\nlow\tO\ndoses\tO\nof\tO\nvasopressin\tB-Chemical\nrestored\tO\nblood\tO\npressure\tO\nwithout\tO\ninhibiting\tO\nthe\tO\ninotropic\tO\neffect\tO\nof\tO\nmilrinone\tB-Chemical\n.\tO\n\nTreatment\tO\nof\tO\ntacrolimus\tB-Chemical\n-\tO\nrelated\tO\nadverse\tO\neffects\tO\nby\tO\nconversion\tO\nto\tO\ncyclosporine\tB-Chemical\nin\tO\nliver\tO\ntransplant\tO\nrecipients\tO\n.\tO\n\nWhen\tO\ntacrolimus\tB-Chemical\nside\tO\neffects\tO\npersist\tO\ndespite\tO\ndose\tO\nreduction\tO\n,\tO\nconversion\tO\nto\tO\ncyclosporine\tB-Chemical\n-\tO\nbased\tO\nimmunosuppression\tO\n(\tO\nCyA\tO\n)\tO\nis\tO\nnecessary\tO\n.\tO\n\nWe\tO\ncharacterized\tO\ntacrolimus\tB-Chemical\nside\tO\neffects\tO\nthat\tO\nwarranted\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n,\tO\nand\tO\noutcomes\tO\nafter\tO\nconversion\tO\n.\tO\n\nOf\tO\n388\tO\nliver\tO\nrecipients\tO\nwho\tO\nreceived\tO\ntacrolimus\tB-Chemical\nas\tO\nprimary\tO\nimmunosuppression\tO\n,\tO\n70\tO\nrequired\tO\nconversion\tO\nto\tO\nCyA\tO\n.\tO\n\nWe\tO\nrecorded\tO\nindication\tO\nfor\tO\nconversion\tO\n,\tO\nwhether\tO\nconversion\tO\nwas\tO\nearly\tO\nor\tO\nlate\tO\nafter\tO\ntransplantation\tO\n,\tO\ntacrolimus\tB-Chemical\ndose\tO\nand\tO\ntrough\tO\nblood\tO\nlevel\tO\nat\tO\nconversion\tO\n,\tO\nand\tO\nincidence\tO\nof\tO\nrejection\tO\nafter\tO\nconversion\tO\n.\tO\n\nConversion\tO\nwas\tO\nearly\tO\nin\tO\n29\tO\npatients\tO\n(\tO\n41\tO\n.\tO\n4\tO\n%\tO\n)\tO\nand\tO\nlate\tO\nin\tO\n41\tO\n(\tO\n58\tO\n.\tO\n6\tO\n%\tO\n)\tO\n.\tO\n\nIndications\tO\nfor\tO\nearly\tO\nconversion\tO\nwere\tO\nneurotoxicity\tB-Disease\n(\tO\n20\tO\n)\tO\n,\tO\n(\tB-Disease\ninsulin\tI-Disease\n-\tI-Disease\ndependent\tI-Disease\n)\tI-Disease\ndiabetes\tI-Disease\nmellitus\tI-Disease\n(\tO\nIDDM\tB-Disease\n)\tO\n(\tO\n5\tO\n)\tO\n,\tO\nnephrotoxicity\tB-Disease\n(\tO\n3\tO\n)\tO\n,\tO\ngastrointestinal\tB-Disease\n(\tI-Disease\nGI\tI-Disease\n)\tI-Disease\ntoxicity\tI-Disease\n(\tO\n6\tO\n)\tO\n,\tO\nand\tO\ncardiomyopathy\tB-Disease\n(\tO\n1\tO\n)\tO\n,\tO\nand\tO\nfor\tO\nlate\tO\nconversion\tO\nwere\tO\nneurotoxicity\tB-Disease\n(\tO\n15\tO\n)\tO\n,\tO\nIDDM\tB-Disease\n(\tO\n12\tO\n)\tO\n,\tO\nnephrotoxicity\tB-Disease\n(\tO\n3\tO\n)\tO\n,\tO\nGI\tB-Disease\ntoxicity\tI-Disease\n(\tO\n5\tO\n)\tO\n,\tO\nhepatotoxicity\tB-Disease\n(\tO\n6\tO\n)\tO\n,\tO\npost\tB-Disease\n-\tI-Disease\ntransplant\tI-Disease\nlmphoproliferate\tI-Disease\ndisease\tI-Disease\n(\tO\nPTLD\tB-Disease\n)\tO\n(\tO\n2\tO\n)\tO\n,\tO\ncardiomyopathy\tB-Disease\n(\tO\n1\tO\n)\tO\n,\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n(\tO\n1\tO\n)\tO\n,\tO\nand\tO\npruritus\tB-Disease\n(\tO\n1\tO\n)\tO\n.\tO\n\nAll\tO\nearly\tO\n-\tO\nconversion\tO\npatients\tO\nshowed\tO\nimprovement\tO\n/\tO\nresolution\tO\nof\tO\nsymptoms\tO\n.\tO\n\nAmong\tO\nlate\tO\n-\tO\nconversion\tO\npatients\tO\n,\tO\n37\tO\n(\tO\n90\tO\n.\tO\n2\tO\n%\tO\n)\tO\nhad\tO\nimprovement\tO\n/\tO\nresolution\tO\n;\tO\nin\tO\n4\tO\n(\tO\n9\tO\n.\tO\n8\tO\n%\tO\n)\tO\n,\tO\nadverse\tO\neffects\tO\npersisted\tO\n.\tO\n\nThe\tO\noverall\tO\nrejection\tO\nrate\tO\nwas\tO\n30\tO\n%\tO\n.\tO\n\nSixty\tO\n-\tO\ntwo\tO\npatients\tO\n(\tO\n88\tO\n.\tO\n6\tO\n%\tO\n)\tO\nare\tO\nalive\tO\nwith\tO\nfunctioning\tO\ngrafts\tO\n686\tO\n+\tO\n/\tO\n-\tO\n362\tO\ndays\tO\n(\tO\nrange\tO\n,\tO\n154\tO\n-\tO\n1433\tO\ndays\tO\n)\tO\nafter\tO\nconversion\tO\n.\tO\n\nWhen\tO\ntacrolimus\tB-Chemical\nside\tO\neffects\tO\nare\tO\nunresponsive\tO\nto\tO\ndose\tO\nreduction\tO\n,\tO\nconversion\tO\nto\tO\nCyA\tO\ncan\tO\nbe\tO\naccomplished\tO\nsafely\tO\n,\tO\nwith\tO\nno\tO\nincreased\tO\nrisk\tO\nof\tO\nrejection\tO\nand\tO\nexcellent\tO\nlong\tO\n-\tO\nterm\tO\noutcome\tO\n.\tO\n\nOcular\tO\nmanifestations\tO\nof\tO\njuvenile\tB-Disease\nrheumatoid\tI-Disease\narthritis\tI-Disease\n.\tO\n\nWe\tO\nfollowed\tO\n210\tO\ncases\tO\nof\tO\njuvenile\tB-Disease\nrheumatoid\tI-Disease\narthritis\tI-Disease\nclosely\tO\nfor\tO\neleven\tO\nyears\tO\n.\tO\n\nThirty\tO\n-\tO\nsix\tO\nof\tO\nthe\tO\n210\tO\npatients\tO\n(\tO\n17\tO\n.\tO\n2\tO\n%\tO\n)\tO\ndeveloped\tO\niridocyclitis\tB-Disease\n.\tO\n\nIridocyclitis\tB-Disease\nwas\tO\nseen\tO\nmost\tO\nfrequently\tO\nin\tO\nyoung\tO\nfemale\tO\npatients\tO\n(\tO\n0\tO\nto\tO\n4\tO\nyears\tO\n)\tO\nwith\tO\nthe\tO\nmonoarticular\tO\nor\tO\npauciatricular\tO\nform\tO\nof\tO\nthe\tO\narthritis\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\n30\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\ndeveloped\tO\nuveitis\tB-Disease\nafter\tO\n16\tO\nyears\tO\nof\tO\nage\tO\n.\tO\n\nAlthough\tO\n61\tO\n%\tO\nof\tO\npatients\tO\nhad\tO\na\tO\nnoncontributory\tO\nocular\tO\nhistory\tO\non\tO\nentry\tO\n,\tO\n42\tO\n%\tO\nhad\tO\nactive\tO\nuveitis\tB-Disease\non\tO\nentry\tO\n.\tO\n\nOur\tO\napproach\tO\nwas\tO\neffective\tO\nin\tO\ndetecting\tO\nuveitis\tB-Disease\nin\tO\nnew\tO\ncases\tO\nand\tO\nexacerbations\tO\nof\tO\nuveitis\tB-Disease\nin\tO\nestablished\tO\ncases\tO\n.\tO\n\nForty\tO\n-\tO\nfour\tO\npercent\tO\nof\tO\npatients\tO\nwith\tO\nuveitis\tB-Disease\nhad\tO\none\tO\nor\tO\nmore\tO\nidentifiable\tO\nsigns\tO\nor\tO\nsymptoms\tO\n,\tO\nsuch\tO\nas\tO\nred\tO\neye\tO\n,\tO\nocular\tB-Disease\npain\tI-Disease\n,\tO\ndecreased\tB-Disease\nvisual\tI-Disease\nacuity\tI-Disease\n,\tO\nor\tO\nphotophobia\tB-Disease\n,\tO\nin\tO\norder\tO\nof\tO\ndecreasing\tO\nfrequency\tO\n.\tO\n\nEven\tO\nafter\tO\nearly\tO\ndetection\tO\nand\tO\nprompt\tO\ntreatment\tO\n,\tO\n41\tO\n%\tO\nof\tO\ncases\tO\nof\tO\nuveitis\tB-Disease\ndid\tO\nnot\tO\nrespond\tO\nto\tO\nmore\tO\nthan\tO\nsix\tO\nmonths\tO\nof\tO\nintensive\tO\ntopical\tO\ntreatment\tO\nwith\tO\ncorticosteroids\tB-Chemical\nand\tO\nmydriatics\tO\n.\tO\n\nDespite\tO\nthis\tO\n,\tO\nthere\tO\nwas\tO\na\tO\ndramatic\tO\ndecrease\tO\nin\tO\nthe\tO\n50\tO\n%\tO\nincidence\tO\nof\tO\nblinding\tO\ncomplications\tO\nof\tO\nuveitis\tB-Disease\ncited\tO\nin\tO\nearlier\tO\nstudies\tO\n.\tO\n\nCataract\tB-Disease\nand\tO\nband\tB-Disease\nkeratopathy\tI-Disease\noccurred\tO\nin\tO\nonly\tO\n22\tO\nand\tO\n13\tO\n%\tO\nof\tO\nour\tO\ngroup\tO\n,\tO\nrespectively\tO\n.\tO\n\nWe\tO\nused\tO\nchloroquine\tB-Chemical\nor\tO\nhydroxychloroquine\tB-Chemical\nin\tO\n173\tO\nof\tO\n210\tO\ncases\tO\nand\tO\nfound\tO\nonly\tO\none\tO\ncase\tO\nof\tO\nchorioretinopathy\tB-Disease\nattributable\tO\nto\tO\nthese\tO\ndrugs\tO\n.\tO\n\nSystemically\tO\nadministered\tO\ncorticosteroids\tB-Chemical\nwere\tO\nused\tO\nin\tO\n75\tO\nof\tO\n210\tO\ncases\tO\n;\tO\na\tO\nsignificant\tO\nnumber\tO\nof\tO\nposterior\tO\nsubcapsular\tO\ncataracts\tB-Disease\nwas\tO\nfound\tO\n.\tO\n\nTypical\tO\nkeratoconjunctivitis\tB-Disease\nsicca\tO\ndeveloped\tO\nin\tO\nthree\tO\nof\tO\nthe\tO\nuveitis\tB-Disease\ncases\tO\n.\tO\n\nThis\tO\nassociation\tO\nwith\tO\nuveitis\tB-Disease\nand\tO\nJRA\tO\nwas\tO\nnot\tO\nnoted\tO\npreviously\tO\n.\tO\n\nSurgical\tO\ntreatment\tO\nof\tO\ncataracts\tB-Disease\n,\tO\nband\tB-Disease\nkeratopathy\tI-Disease\n,\tO\nand\tO\nglaucoma\tB-Disease\nachieved\tO\nuniformly\tO\ndiscouraging\tO\nresults\tO\n.\tO\n\nCyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\nin\tO\nfreely\tO\n-\tO\nmoving\tO\nconscious\tO\nrats\tO\n:\tO\nbehavioral\tO\napproach\tO\nto\tO\na\tO\nnew\tO\nmodel\tO\nof\tO\nvisceral\tB-Disease\npain\tI-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\ndevelop\tO\na\tO\nmodel\tO\nof\tO\nvisceral\tB-Disease\npain\tI-Disease\nin\tO\nrats\tO\nusing\tO\na\tO\nbehavioral\tO\napproach\tO\n.\tO\n\nCyclophosphamide\tB-Chemical\n(\tO\nCP\tB-Chemical\n)\tO\n,\tO\nan\tO\nantitumoral\tO\nagent\tO\nknown\tO\nto\tO\nproduce\tO\ntoxic\tO\neffects\tO\non\tO\nthe\tO\nbladder\tO\nwall\tO\nthrough\tO\nits\tO\nmain\tO\ntoxic\tO\nmetabolite\tO\nacrolein\tB-Chemical\n,\tO\nwas\tO\nused\tO\nto\tO\ninduce\tO\ncystitis\tB-Disease\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nCP\tB-Chemical\nwas\tO\nadministered\tO\nat\tO\ndoses\tO\nof\tO\n50\tO\n,\tO\n100\tO\nand\tO\n200\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\n\ni\tO\n.\tO\np\tO\n.\tO\nto\tO\nmale\tO\nrats\tO\n,\tO\nand\tO\ntheir\tO\nbehavior\tO\nobserved\tO\nand\tO\nscored\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nmorphine\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nto\tO\n4\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\non\tO\nCP\tB-Chemical\n-\tO\ninduced\tO\nbehavioral\tO\nmodifications\tO\nwere\tO\ntested\tO\nadministered\tO\nalone\tO\nand\tO\nafter\tO\nnaloxone\tB-Chemical\n(\tO\n1\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\n90\tO\nminutes\tO\nafter\tO\nCP\tB-Chemical\ninjection\tO\n,\tO\nthat\tO\nis\tO\n,\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\nadministration\tO\nof\tO\nmorphine\tB-Chemical\n,\tO\nthe\tO\nbladder\tO\nwas\tO\nremoved\tO\nin\tO\nsome\tO\nrats\tO\nfor\tO\nhistological\tO\nexamination\tO\n.\tO\n\nFinally\tO\n,\tO\nto\tO\nshow\tO\nthat\tO\nthe\tO\nbladder\tO\nis\tO\nessential\tO\nfor\tO\nthe\tO\nCP\tB-Chemical\n-\tO\ninduced\tO\nbehavioral\tO\nmodifications\tO\n,\tO\nfemale\tO\nrats\tO\nalso\tO\nreceived\tO\nCP\tB-Chemical\nat\tO\ndoses\tO\nof\tO\n200\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\n\ni\tO\n.\tO\np\tO\n.\tO\nand\tO\nof\tO\n20\tO\nmg\tO\n.\tO\nby\tO\nthe\tO\nintravesical\tO\nroute\tO\n,\tO\nand\tO\nacrolein\tB-Chemical\nat\tO\ndoses\tO\nof\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n.\tO\nby\tO\nthe\tO\nintravesical\tO\nroute\tO\nand\tO\nof\tO\n5\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\n\ni\tO\n.\tO\nv\tO\n.\tO\nRESULTS\tO\n:\tO\nCP\tB-Chemical\ndose\tO\n-\tO\nrelatedly\tO\ninduced\tO\nmarked\tO\nbehavioral\tO\nmodifications\tO\nin\tO\nmale\tO\nrats\tO\n:\tO\nbreathing\tO\nrate\tO\ndecrease\tO\n,\tO\nclosing\tO\nof\tO\nthe\tO\neyes\tO\nand\tO\noccurrence\tO\nof\tO\nspecific\tO\npostures\tO\n.\tO\n\nMorphine\tB-Chemical\ndose\tO\n-\tO\ndependently\tO\nreversed\tO\nthese\tO\nbehavioral\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nA\tO\ndose\tO\nof\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\nproduced\tO\na\tO\nreduction\tO\nof\tO\nalmost\tO\n50\tO\n%\tO\nof\tO\nthe\tO\nbehavioral\tO\nscore\tO\ninduced\tO\nby\tO\nCP\tB-Chemical\n200\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\n\nThis\tO\neffect\tO\nwas\tO\ncompletely\tO\nprevented\tO\nby\tO\npretreatment\tO\nwith\tO\nnaloxone\tB-Chemical\n.\tO\n\nAt\tO\nthe\tO\ntime\tO\nof\tO\nadministration\tO\nof\tO\nmorphine\tB-Chemical\n,\tO\nhistological\tO\nmodifications\tO\nof\tO\nthe\tO\nbladder\tO\nwall\tO\n,\tO\nsuch\tO\nas\tO\nchorionic\tO\nand\tO\nmuscle\tO\nlayer\tO\nedema\tB-Disease\n,\tO\nwere\tO\nobserved\tO\n.\tO\n\nIn\tO\nfemale\tO\nrats\tO\n,\tO\nCP\tB-Chemical\n200\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\n\ni\tO\n.\tO\np\tO\n.\tO\nproduced\tO\nthe\tO\nsame\tO\nmarked\tO\nbehavioral\tO\nmodifications\tO\nas\tO\nthose\tO\nobserved\tO\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nAdministered\tO\nat\tO\nthe\tO\ndose\tO\nof\tO\n20\tO\nmg\tO\n.\tO\nintravesically\tO\n,\tO\nCP\tB-Chemical\ndid\tO\nnot\tO\nproduce\tO\nany\tO\nbehavioral\tO\neffects\tO\n,\tO\nwhereas\tO\nacrolein\tB-Chemical\nat\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n.\tO\nintravesically\tO\ninduced\tO\nbehavioral\tO\nmodifications\tO\nidentical\tO\nto\tO\nthose\tO\nunder\tO\nCP\tB-Chemical\n200\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\n\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\nwith\tO\nthe\tO\nsame\tO\nmaximal\tO\nlevels\tO\n.\tO\n\nConversely\tO\n,\tO\nacrolein\tB-Chemical\n5\tO\nmg\tO\n.\tO\n/\tO\nkg\tO\n.\tO\n\ni\tO\n.\tO\nv\tO\n.\tO\ndid\tO\nnot\tO\nproduce\tO\nany\tO\nbehavioral\tO\neffects\tO\nat\tO\nall\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nOverall\tO\n,\tO\nthese\tO\nresults\tO\nindicate\tO\nthat\tO\nthis\tO\nexperimental\tO\nmodel\tO\nof\tO\nCP\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\nmay\tO\nbe\tO\nan\tO\ninteresting\tO\nnew\tO\nbehavioral\tO\nmodel\tO\nof\tO\ninflammatory\tO\nvisceral\tB-Disease\npain\tI-Disease\n,\tO\nallowing\tO\na\tO\nbetter\tO\nunderstanding\tO\nof\tO\nthese\tO\npainful\tB-Disease\nsyndromes\tI-Disease\nand\tO\nthus\tO\na\tO\nbetter\tO\ntherapeutic\tO\napproach\tO\nto\tO\nthem\tO\n.\tO\n\nPrednisolone\tB-Chemical\n-\tO\ninduced\tO\nmuscle\tB-Disease\ndysfunction\tI-Disease\nis\tO\ncaused\tO\nmore\tO\nby\tO\natrophy\tB-Disease\nthan\tO\nby\tO\naltered\tO\nacetylcholine\tB-Chemical\nreceptor\tO\nexpression\tO\n.\tO\n\nLarge\tO\ndoses\tO\nof\tO\nglucocorticoids\tO\ncan\tO\nalter\tO\nmuscle\tO\nphysiology\tO\nand\tO\nsusceptibility\tO\nto\tO\nneuromuscular\tO\nblocking\tO\ndrugs\tO\nby\tO\nmechanisms\tO\nnot\tO\nclearly\tO\nunderstood\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\neffects\tO\nof\tO\nmoderate\tO\nand\tO\nlarge\tO\ndoses\tO\nof\tO\nprednisolone\tB-Chemical\non\tO\nmuscle\tO\nfunction\tO\nand\tO\npharmacology\tO\n,\tO\nand\tO\ntheir\tO\nrelationship\tO\nto\tO\nchanges\tO\nin\tO\nmuscle\tO\nsize\tO\nand\tO\nacetylcholine\tB-Chemical\nreceptor\tO\n(\tO\nAChR\tO\n)\tO\nexpression\tO\n.\tO\n\nWith\tO\ninstitutional\tO\napproval\tO\n,\tO\n35\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\nrandomly\tO\nallocated\tO\nto\tO\nreceive\tO\ndaily\tO\nsubcutaneous\tO\ndoses\tO\nof\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nprednisolone\tB-Chemical\n(\tO\nP10\tO\ngroup\tO\n)\tO\n,\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\nprednisolone\tB-Chemical\n(\tO\nP100\tO\ngroup\tO\n)\tO\n,\tO\nor\tO\nan\tO\nequal\tO\nvolume\tO\nof\tO\nsaline\tO\n(\tO\nS\tO\ngroup\tO\n)\tO\nfor\tO\n7\tO\ndays\tO\n.\tO\n\nA\tO\nfourth\tO\ngroup\tO\nof\tO\nrats\tO\nwas\tO\npair\tO\nfed\tO\n(\tO\nfood\tO\nrestricted\tO\n)\tO\nwith\tO\nthe\tO\nP100\tO\nrats\tO\nfor\tO\n7\tO\ndays\tO\n(\tO\nFR\tO\ngroup\tO\n)\tO\n.\tO\n\nOn\tO\nDay\tO\n8\tO\n,\tO\nthe\tO\nnerve\tO\n-\tO\nevoked\tO\npeak\tO\ntwitch\tO\ntensions\tO\n,\tO\ntetanic\tB-Disease\ntensions\tO\n,\tO\nand\tO\nfatigability\tO\n,\tO\nand\tO\nthe\tO\ndose\tO\n-\tO\nresponse\tO\ncurves\tO\nof\tO\nd\tB-Chemical\n-\tI-Chemical\ntubocurarine\tI-Chemical\nin\tO\nthe\tO\ntibialis\tO\ncranialis\tO\nmuscle\tO\nwere\tO\nmeasured\tO\nin\tO\nvivo\tO\nand\tO\nrelated\tO\nto\tO\nmuscle\tO\nmass\tO\nor\tO\nexpression\tO\nof\tO\nAChRs\tO\n.\tO\n\nRate\tO\nof\tO\nbody\tO\nweight\tO\ngain\tO\nwas\tO\ndepressed\tO\nin\tO\nthe\tO\nP100\tO\n,\tO\nFR\tO\n,\tO\nand\tO\nP10\tO\ngroups\tO\ncompared\tO\nwith\tO\nthe\tO\nS\tO\ngroup\tO\n.\tO\n\nTibialis\tO\nmuscle\tO\nmass\tO\nwas\tO\nsmaller\tO\nin\tO\nthe\tO\nP100\tO\ngroup\tO\nthan\tO\nin\tO\nthe\tO\nP10\tO\nor\tO\nS\tO\ngroups\tO\n.\tO\n\nThe\tO\nevoked\tO\npeak\tO\ntwitch\tO\nand\tO\ntetanic\tB-Disease\ntensions\tO\nwere\tO\nless\tO\nin\tO\nthe\tO\nP100\tO\ngroup\tO\nthan\tO\nin\tO\nthe\tO\nP10\tO\nor\tO\nS\tO\ngroups\tO\n,\tO\nhowever\tO\n,\tO\ntension\tO\nper\tO\nmilligram\tO\nof\tO\nmuscle\tO\nmass\tO\nwas\tO\ngreater\tO\nin\tO\nthe\tO\nP100\tO\ngroup\tO\nthan\tO\nin\tO\nthe\tO\nS\tO\ngroup\tO\n.\tO\n\nThe\tO\n50\tO\n%\tO\neffective\tO\ndose\tO\nof\tO\nd\tB-Chemical\n-\tI-Chemical\ntubocurarine\tI-Chemical\n(\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\nin\tO\nthe\tO\ntibialis\tO\nmuscle\tO\nwas\tO\nsmaller\tO\nin\tO\nthe\tO\nP10\tO\n(\tO\n33\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n4\tO\n)\tO\nthan\tO\nin\tO\nthe\tO\nS\tO\n(\tO\n61\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n0\tO\n)\tO\nor\tO\nthe\tO\nP100\tO\n(\tO\n71\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n9\tO\n.\tO\n6\tO\n)\tO\ngroups\tO\n.\tO\n\nAChR\tO\nexpression\tO\nwas\tO\nless\tO\nin\tO\nthe\tO\nP10\tO\ngroup\tO\nthan\tO\nin\tO\nthe\tO\nS\tO\ngroup\tO\n.\tO\n\nThe\tO\nevoked\tO\ntensions\tO\ncorrelated\tO\nwith\tO\nmuscle\tO\nmass\tO\n(\tO\nr\tO\n(\tO\n2\tO\n)\tO\n=\tO\n0\tO\n.\tO\n32\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nhowever\tO\n,\tO\nnot\tO\nwith\tO\nexpression\tO\nof\tO\nAChR\tO\n.\tO\n\nThe\tO\n50\tO\n%\tO\neffective\tO\ndose\tO\nof\tO\nd\tB-Chemical\n-\tI-Chemical\ntubocurarine\tI-Chemical\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nmuscle\tO\nmass\tO\nor\tO\nAChR\tO\nexpression\tO\n.\tO\n\nOur\tO\nresults\tO\nsuggest\tO\nthat\tO\nthe\tO\nneuromuscular\tB-Disease\ndysfunction\tI-Disease\nafter\tO\nprednisolone\tB-Chemical\nis\tO\ndose\tO\n-\tO\ndependent\tO\n,\tO\nand\tO\nderives\tO\nprimarily\tO\nfrom\tO\nmuscle\tB-Disease\natrophy\tI-Disease\nand\tO\nderives\tO\nless\tO\nso\tO\nfrom\tO\nchanges\tO\nin\tO\nAChR\tO\nexpression\tO\n.\tO\n\nIMPLICATIONS\tO\n:\tO\nThe\tO\nmechanisms\tO\nby\tO\nwhich\tO\nchronic\tO\nglucocorticoid\tO\ntherapy\tO\nalters\tO\nneuromuscular\tO\nphysiology\tO\nand\tO\npharmacology\tO\nare\tO\nunclear\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\nthe\tO\nobserved\tO\neffects\tO\nare\tO\ndose\tO\n-\tO\ndependent\tO\nand\tO\nderive\tO\nprimarily\tO\nfrom\tO\nmuscle\tB-Disease\natrophy\tI-Disease\nand\tO\nderive\tO\nless\tO\nfrom\tO\nchanges\tO\nin\tO\nacetylcholine\tB-Chemical\nreceptor\tO\nexpression\tO\n.\tO\n\nApomorphine\tB-Chemical\n:\tO\nan\tO\nunderutilized\tO\ntherapy\tO\nfor\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nApomorphine\tB-Chemical\nwas\tO\nthe\tO\nfirst\tO\ndopaminergic\tO\ndrug\tO\never\tO\nused\tO\nto\tO\ntreat\tO\nsymptoms\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nWhile\tO\npowerful\tO\nantiparkinsonian\tO\neffects\tO\nhad\tO\nbeen\tO\nobserved\tO\nas\tO\nearly\tO\nas\tO\n1951\tO\n,\tO\nthe\tO\npotential\tO\nof\tO\ntreating\tO\nfluctuating\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nby\tO\nsubcutaneous\tO\nadministration\tO\nof\tO\napomorphine\tB-Chemical\nhas\tO\nonly\tO\nrecently\tO\nbecome\tO\nthe\tO\nsubject\tO\nof\tO\nsystematic\tO\nstudy\tO\n.\tO\n\nA\tO\nnumber\tO\nof\tO\nsmall\tO\nscale\tO\nclinical\tO\ntrials\tO\nhave\tO\nunequivocally\tO\nshown\tO\nthat\tO\nintermittent\tO\nsubcutaneous\tO\napomorphine\tB-Chemical\ninjections\tO\nproduce\tO\nantiparkinsonian\tO\nbenefit\tO\nclose\tO\nif\tO\nnot\tO\nidentical\tO\nto\tO\nthat\tO\nseen\tO\nwith\tO\nlevodopa\tB-Chemical\nand\tO\nthat\tO\napomorphine\tB-Chemical\nrescue\tO\ninjections\tO\ncan\tO\nreliably\tO\nrevert\tO\noff\tO\n-\tO\nperiods\tO\neven\tO\nin\tO\npatients\tO\nwith\tO\ncomplex\tO\non\tO\n-\tO\noff\tO\nmotor\tO\nswings\tO\n.\tO\n\nContinuous\tO\nsubcutaneous\tO\napomorphine\tB-Chemical\ninfusions\tO\ncan\tO\nreduce\tO\ndaily\tO\noff\tO\n-\tO\ntime\tO\nby\tO\nmore\tO\nthan\tO\n50\tO\n%\tO\nin\tO\nthis\tO\ngroup\tO\nof\tO\npatients\tO\n,\tO\nwhich\tO\nappears\tO\nto\tO\nbe\tO\na\tO\nstronger\tO\neffect\tO\nthan\tO\nthat\tO\ngenerally\tO\nseen\tO\nwith\tO\nadd\tO\n-\tO\non\tO\ntherapy\tO\nwith\tO\noral\tO\ndopamine\tB-Chemical\nagonists\tO\nor\tO\nCOMT\tO\ninhibitors\tO\n.\tO\n\nExtended\tO\nfollow\tO\n-\tO\nup\tO\nstudies\tO\nof\tO\nup\tO\nto\tO\n8\tO\nyears\tO\nhave\tO\ndemonstrated\tO\nlong\tO\n-\tO\nterm\tO\npersistence\tO\nof\tO\napomorphine\tB-Chemical\nefficacy\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthere\tO\nis\tO\nconvincing\tO\nclinical\tO\nevidence\tO\nthat\tO\nmonotherapy\tO\nwith\tO\ncontinuous\tO\nsubcutaneous\tO\napomorphine\tB-Chemical\ninfusions\tO\nis\tO\nassociated\tO\nwith\tO\nmarked\tO\nreductions\tO\nof\tO\npreexisting\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n.\tO\n\nThe\tO\nmain\tO\nside\tO\neffects\tO\nof\tO\nsubcutaneous\tO\napomorphine\tB-Chemical\ntreatment\tO\nare\tO\nrelated\tO\nto\tO\ncutaneous\tO\ntolerability\tO\nproblems\tO\n,\tO\nwhereas\tO\nsedation\tO\nand\tO\npsychiatric\tB-Disease\ncomplications\tO\nplay\tO\na\tO\nlesser\tO\nrole\tO\n.\tO\n\nGiven\tO\nthe\tO\nmarked\tO\ndegree\tO\nof\tO\nefficacy\tO\nof\tO\nsubcutaneous\tO\napomorphine\tB-Chemical\ntreatment\tO\nin\tO\nfluctuating\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n,\tO\nthis\tO\napproach\tO\nseems\tO\nto\tO\ndeserve\tO\nmore\tO\nwidespread\tO\nclinical\tO\nuse\tO\n.\tO\n\nProbing\tO\nperipheral\tO\nand\tO\ncentral\tO\ncholinergic\tO\nsystem\tO\nresponses\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\npharmacological\tO\nresponse\tO\nto\tO\ndrugs\tO\nthat\tO\nact\tO\non\tO\nthe\tO\ncholinergic\tO\nsystem\tO\nof\tO\nthe\tO\niris\tO\nhas\tO\nbeen\tO\nused\tO\nto\tO\npredict\tO\ndeficits\tO\nin\tO\ncentral\tO\ncholinergic\tO\nfunctioning\tO\ndue\tO\nto\tO\ndiseases\tO\nsuch\tO\nas\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n,\tO\nyet\tO\ncorrelations\tO\nbetween\tO\ncentral\tO\nand\tO\nperipheral\tO\nresponses\tO\nhave\tO\nnot\tO\nbeen\tO\nproperly\tO\nstudied\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\neffect\tO\nof\tO\nnormal\tO\naging\tO\non\tO\n(\tO\n1\tO\n)\tO\nthe\tO\ntropicamide\tB-Chemical\n-\tO\ninduced\tO\nincrease\tO\nin\tO\npupil\tO\ndiameter\tO\n,\tO\nand\tO\n(\tO\n2\tO\n)\tO\nthe\tO\nreversal\tO\nof\tO\nthis\tO\neffect\tO\nwith\tO\npilocarpine\tB-Chemical\n.\tO\n\nScopolamine\tB-Chemical\nwas\tO\nused\tO\nas\tO\na\tO\npositive\tO\ncontrol\tO\nto\tO\ndetect\tO\nage\tO\n-\tO\ndependent\tO\nchanges\tO\nin\tO\ncentral\tO\ncholinergic\tO\nfunctioning\tO\nin\tO\nthe\tO\nelderly\tO\n.\tO\n\nDESIGN\tO\n:\tO\nRandomized\tO\ndouble\tO\n-\tO\nblind\tO\ncontrolled\tO\ntrial\tO\n.\tO\n\nPARTICIPANTS\tO\n:\tO\nTen\tO\nhealthy\tO\nelderly\tO\n(\tO\nmean\tO\nage\tO\n70\tO\n)\tO\nand\tO\n9\tO\nyoung\tO\n(\tO\nmean\tO\nage\tO\n33\tO\n)\tO\nvolunteers\tO\n.\tO\n\nINTERVENTIONS\tO\n:\tO\nPupil\tO\ndiameter\tO\nwas\tO\nmonitored\tO\nusing\tO\na\tO\ncomputerized\tO\ninfrared\tO\npupillometer\tO\nover\tO\n4\tO\nhours\tO\n.\tO\n\nThe\tO\nstudy\tO\ninvolved\tO\n4\tO\nsessions\tO\n.\tO\n\nIn\tO\n1\tO\nsession\tO\n,\tO\ntropicamide\tB-Chemical\n(\tO\n20\tO\nmicroL\tO\n,\tO\n0\tO\n.\tO\n01\tO\n%\tO\n)\tO\nwas\tO\nadministered\tO\nto\tO\none\tO\neye\tO\nand\tO\nplacebo\tO\nto\tO\nthe\tO\nother\tO\n.\tO\n\nIn\tO\nanother\tO\nsession\tO\n,\tO\ntropicamide\tB-Chemical\n(\tO\n20\tO\nmicroL\tO\n,\tO\n0\tO\n.\tO\n01\tO\n%\tO\n)\tO\nwas\tO\nadministered\tO\nto\tO\nboth\tO\neyes\tO\n,\tO\nfollowed\tO\n23\tO\nminutes\tO\nlater\tO\nby\tO\nthe\tO\napplication\tO\nof\tO\npilocarpine\tB-Chemical\n(\tO\n20\tO\nmicroL\tO\n,\tO\n0\tO\n.\tO\n1\tO\n%\tO\n)\tO\nto\tO\none\tO\neye\tO\nand\tO\nplacebo\tO\nto\tO\nthe\tO\nother\tO\n.\tO\n\nAll\tO\neye\tO\ndrops\tO\nwere\tO\ngiven\tO\nin\tO\na\tO\nrandomized\tO\norder\tO\n.\tO\n\nIn\tO\n2\tO\nseparate\tO\nsessions\tO\n,\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nscopolamine\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n,\tO\nintravenously\tO\n)\tO\nor\tO\nplacebo\tO\nwas\tO\nadministered\tO\n,\tO\nand\tO\nthe\tO\neffects\tO\non\tO\nword\tO\nrecall\tO\nwere\tO\nmeasured\tO\nusing\tO\nthe\tO\nBuschke\tO\nSelective\tO\nReminding\tO\nTest\tO\nover\tO\n2\tO\nhours\tO\n.\tO\n\nOUTCOME\tO\nMEASURES\tO\n:\tO\nPupil\tO\nsize\tO\nat\tO\ntime\tO\npoints\tO\nafter\tO\nadministration\tO\nof\tO\ntropicamide\tB-Chemical\nand\tO\npilocarpine\tB-Chemical\n;\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\nimpairment\tB-Disease\nin\tI-Disease\nword\tI-Disease\nrecall\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nThere\tO\nwas\tO\nno\tO\nsignificant\tO\ndifference\tO\nbetween\tO\nelderly\tO\nand\tO\nyoung\tO\nvolunteers\tO\nin\tO\npupillary\tO\nresponse\tO\nto\tO\ntropicamide\tB-Chemical\nat\tO\nany\tO\ntime\tO\npoint\tO\n(\tO\np\tO\n>\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\nelderly\tO\ngroup\tO\nhad\tO\na\tO\nsignificantly\tO\ngreater\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nnet\tO\ndecrease\tO\nin\tO\npupil\tO\nsize\tO\n85\tO\n,\tO\n125\tO\n,\tO\n165\tO\nand\tO\n215\tO\nminutes\tO\nafter\tO\nadministration\tO\n,\tO\ncompared\tO\nwith\tO\nthe\tO\nyoung\tO\ngroup\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCompared\tO\nwith\tO\nthe\tO\nyoung\tO\ngroup\tO\n,\tO\nthe\tO\nelderly\tO\ngroup\tO\nhad\tO\ngreater\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\nimpairment\tB-Disease\nin\tI-Disease\nword\tI-Disease\nrecall\tI-Disease\n60\tO\n,\tO\n90\tO\nand\tO\n120\tO\nminutes\tO\nafter\tO\nadministration\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThere\tO\nis\tO\nan\tO\nage\tO\n-\tO\nrelated\tO\npupillary\tO\nresponse\tO\nto\tO\npilocarpine\tB-Chemical\nthat\tO\nis\tO\nnot\tO\nfound\tO\nwith\tO\ntropicamide\tB-Chemical\n.\tO\n\nThus\tO\n,\tO\npilocarpine\tB-Chemical\nmay\tO\nbe\tO\nuseful\tO\nto\tO\nassess\tO\nvariations\tO\nin\tO\ncentral\tO\ncholinergic\tO\nfunction\tO\nin\tO\nelderly\tO\npatients\tO\n.\tO\n\nPain\tB-Disease\nresponses\tO\nin\tO\nmethadone\tB-Chemical\n-\tO\nmaintained\tO\nopioid\tO\nabusers\tO\n.\tO\n\nProviding\tO\npain\tB-Disease\nmanagement\tO\nfor\tO\nknown\tO\nopioid\tO\nabusers\tO\nis\tO\na\tO\nchallenging\tO\nclinical\tO\ntask\tO\n,\tO\nin\tO\npart\tO\nbecause\tO\nlittle\tO\nis\tO\nknown\tO\nabout\tO\ntheir\tO\npain\tB-Disease\nexperience\tO\nand\tO\nanalgesic\tO\nrequirements\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\ndescribe\tO\npain\tB-Disease\ntolerance\tO\nand\tO\nanalgesic\tO\nresponse\tO\nin\tO\na\tO\nsample\tO\nof\tO\nopioid\tB-Disease\naddicts\tI-Disease\nstabilized\tO\nin\tO\nmethadone\tB-Chemical\n-\tO\nmaintenance\tO\n(\tO\nMM\tO\n)\tO\ntreatment\tO\n(\tO\nn\tO\n=\tO\n60\tO\n)\tO\nin\tO\ncomparison\tO\nto\tO\nmatched\tO\nnondependent\tO\ncontrol\tO\nsubjects\tO\n(\tO\nn\tO\n=\tO\n60\tO\n)\tO\n.\tO\n\nBy\tO\nusing\tO\na\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ntwo\tO\n-\tO\nway\tO\nfactorial\tO\ndesign\tO\n,\tO\ntolerance\tO\nto\tO\ncold\tO\n-\tO\npressor\tO\n(\tO\nCP\tO\n)\tO\npain\tB-Disease\nwas\tO\nexamined\tO\n,\tO\nboth\tO\nbefore\tO\nand\tO\nafter\tO\noral\tO\nadministration\tO\nof\tO\ntherapeutic\tO\ndoses\tO\nof\tO\ncommon\tO\nopioid\tO\n(\tO\nhydromorphone\tB-Chemical\n2\tO\nmg\tO\n)\tO\nand\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\n(\tO\nketorolac\tB-Chemical\n10\tO\nmg\tO\n)\tO\nanalgesic\tO\nagents\tO\n.\tO\n\nResults\tO\nshowed\tO\nthat\tO\nMM\tO\nindividuals\tO\nwere\tO\nsignificantly\tO\nless\tO\ntolerant\tO\nof\tO\nCP\tO\npain\tB-Disease\nthan\tO\ncontrol\tO\nsubjects\tO\n,\tO\nreplicating\tO\nprevious\tO\nwork\tO\n.\tO\n\nAnalgesic\tO\neffects\tO\nwere\tO\nsignificant\tO\nneither\tO\nfor\tO\nmedication\tO\nnor\tO\ngroup\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nMM\tO\nopioid\tO\nabusers\tO\nrepresent\tO\na\tO\npain\tB-Disease\n-\tI-Disease\nintolerant\tI-Disease\nsubset\tO\nof\tO\nclinical\tO\npatients\tO\n.\tO\n\nTheir\tO\ncomplaints\tO\nof\tO\npain\tB-Disease\nshould\tO\nbe\tO\nevaluated\tO\nseriously\tO\nand\tO\nmanaged\tO\naggressively\tO\n.\tO\n\nHigh\tO\n-\tO\ndose\tO\nmethylprednisolone\tB-Chemical\nmay\tO\ndo\tO\nmore\tO\nharm\tO\nfor\tO\nspinal\tB-Disease\ncord\tI-Disease\ninjury\tI-Disease\n.\tO\n\nBecause\tO\nof\tO\nthe\tO\nNational\tO\nAcute\tO\nSpinal\tB-Disease\nCord\tI-Disease\nInjury\tI-Disease\nStudies\tO\n(\tO\nNASCIS\tO\n)\tO\n,\tO\nhigh\tO\n-\tO\ndose\tO\nmethylprednisolone\tB-Chemical\nbecame\tO\nthe\tO\nstandard\tO\nof\tO\ncare\tO\nfor\tO\nthe\tO\nacute\tO\nspinal\tB-Disease\ncord\tI-Disease\ninjury\tI-Disease\n.\tO\n\nIn\tO\nthe\tO\nNASCIS\tO\n,\tO\nthere\tO\nwas\tO\nno\tO\nmention\tO\nregarding\tO\nthe\tO\npossibility\tO\nof\tO\nacute\tO\ncorticosteroid\tB-Chemical\nmyopathy\tB-Disease\nthat\tO\nhigh\tO\n-\tO\ndose\tO\nmethylprednisolone\tB-Chemical\nmay\tO\ncause\tO\n.\tO\n\nThe\tO\ndosage\tO\nof\tO\nmethylprednisolone\tB-Chemical\nrecommended\tO\nby\tO\nthe\tO\nNASCIS\tO\n3\tO\nis\tO\nthe\tO\nhighest\tO\ndose\tO\nof\tO\nsteroids\tB-Chemical\never\tO\nbeing\tO\nused\tO\nduring\tO\na\tO\n2\tO\n-\tO\nday\tO\nperiod\tO\nfor\tO\nany\tO\nclinical\tO\ncondition\tO\n.\tO\n\nWe\tO\nhypothesize\tO\nthat\tO\nit\tO\nmay\tO\ncause\tO\nsome\tO\ndamage\tB-Disease\nto\tI-Disease\nthe\tI-Disease\nmuscle\tI-Disease\nof\tO\nspinal\tB-Disease\ncord\tI-Disease\ninjury\tI-Disease\npatients\tO\n.\tO\n\nFurther\tO\n,\tO\nsteroid\tB-Chemical\nmyopathy\tB-Disease\nrecovers\tO\nnaturally\tO\nand\tO\nthe\tO\nneurological\tO\nimprovement\tO\nshown\tO\nin\tO\nthe\tO\nNASCIS\tO\nmay\tO\nbe\tO\njust\tO\na\tO\nrecording\tO\nof\tO\nthis\tO\nnatural\tO\nmotor\tO\nrecovery\tO\nfrom\tO\nthe\tO\nsteroid\tB-Chemical\nmyopathy\tB-Disease\n,\tO\ninstead\tO\nof\tO\nany\tO\nprotection\tO\nthat\tO\nmethylprednisolone\tB-Chemical\noffers\tO\nto\tO\nthe\tO\nspinal\tB-Disease\ncord\tI-Disease\ninjury\tI-Disease\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\ndiscussion\tO\nconsidering\tO\nthe\tO\npossibility\tO\nthat\tO\nthe\tO\nmethylprednisolone\tB-Chemical\nrecommended\tO\nby\tO\nNASCIS\tO\nmay\tO\ncause\tO\nacute\tO\ncorticosteroid\tB-Chemical\nmyopathy\tB-Disease\n.\tO\n\nConversion\tO\nto\tO\nrapamycin\tB-Chemical\nimmunosuppression\tO\nin\tO\nrenal\tO\ntransplant\tO\nrecipients\tO\n:\tO\nreport\tO\nof\tO\nan\tO\ninitial\tO\nexperience\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nis\tO\nto\tO\nevaluate\tO\nthe\tO\neffects\tO\nof\tO\nRAPA\tB-Chemical\nconversion\tO\nin\tO\npatients\tO\nundergoing\tO\ncyclosporine\tB-Chemical\n(\tO\nCsA\tB-Chemical\n)\tO\nor\tO\ntacrolimus\tB-Chemical\n(\tO\nTac\tB-Chemical\n)\tO\ntoxicity\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nTwenty\tO\nrenal\tO\ntransplant\tO\nrecipients\tO\nwere\tO\nswitched\tO\nto\tO\nfixed\tO\ndose\tO\nrapamycin\tB-Chemical\n(\tO\nRAPA\tB-Chemical\n)\tO\n(\tO\n5\tO\nmg\tO\n/\tO\nday\tO\n)\tO\n0\tO\nto\tO\n204\tO\nmonths\tO\nposttransplant\tO\n.\tO\n\nDrug\tO\nmonitoring\tO\nwas\tO\nnot\tO\ninitially\tO\nused\tO\nto\tO\nadjust\tO\ndoses\tO\n.\tO\n\nThe\tO\nindications\tO\nfor\tO\nswitch\tO\nwere\tO\nchronic\tO\nCsA\tB-Chemical\nor\tO\nTac\tB-Chemical\nnephrotoxicity\tB-Disease\n(\tO\n12\tO\n)\tO\n,\tO\nacute\tO\nCsA\tB-Chemical\nor\tO\nTac\tB-Chemical\ntoxicity\tB-Disease\n(\tO\n3\tO\n)\tO\n,\tO\nsevere\tO\nfacial\tB-Disease\ndysmorphism\tI-Disease\n(\tO\n2\tO\n)\tO\n,\tO\nposttransplant\tB-Disease\nlymphoproliferative\tI-Disease\ndisorder\tI-Disease\n(\tO\nPTLD\tB-Disease\n)\tO\nin\tO\nremission\tO\n(\tO\n2\tO\n)\tO\n,\tO\nand\tO\nhepatotoxicity\tB-Disease\nin\tO\n1\tO\n.\tO\n\nFollow\tO\n-\tO\nup\tO\nis\tO\n7\tO\nto\tO\n24\tO\nmonths\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIn\tO\nthe\tO\n12\tO\npatients\tO\nswitched\tO\nbecause\tO\nof\tO\nchronic\tO\nnephrotoxicity\tB-Disease\nthere\tO\nwas\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nserum\tO\ncreatinine\tB-Chemical\n[\tO\n233\tO\n+\tO\n/\tO\n-\tO\n34\tO\nto\tO\n210\tO\n+\tO\n/\tO\n-\tO\n56\tO\nmicromol\tO\n/\tO\nliter\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nat\tO\n6\tO\nmonths\tO\n]\tO\n.\tO\n\nFacial\tB-Disease\ndysmorphism\tI-Disease\nimproved\tO\nin\tO\ntwo\tO\npatients\tO\n.\tO\n\nNo\tO\nrelapse\tO\nof\tO\nPTLD\tB-Disease\nwas\tO\nobserved\tO\n.\tO\n\nFive\tO\npatients\tO\ndeveloped\tO\npneumonia\tB-Disease\n(\tO\ntwo\tO\nPneumocystis\tB-Disease\ncarinii\tI-Disease\npneumonia\tI-Disease\n,\tO\none\tO\ninfectious\tB-Disease\nmononucleosis\tI-Disease\nwith\tO\npolyclonal\tO\nPTLD\tB-Disease\nlung\tO\ninfiltrate\tO\n)\tO\nand\tO\ntwo\tO\nhad\tO\nbronchiolitis\tB-Disease\nobliterans\tI-Disease\n.\tO\n\nThere\tO\nwere\tO\nno\tO\ndeaths\tO\n.\tO\n\nRAPA\tB-Chemical\nwas\tO\ndiscontinued\tO\nin\tO\nfour\tO\npatients\tO\n,\tO\nbecause\tO\nof\tO\npneumonia\tB-Disease\nin\tO\ntwo\tO\n,\tO\nPTLD\tB-Disease\nin\tO\none\tO\n,\tO\nand\tO\noral\tO\naphtous\tB-Disease\nulcers\tI-Disease\nin\tO\none\tO\n.\tO\n\nRAPA\tB-Chemical\nlevels\tO\nwere\tO\nhigh\tO\n(\tO\n>\tO\n15\tO\nng\tO\n/\tO\nml\tO\n)\tO\nin\tO\n7\tO\nof\tO\n13\tO\n(\tO\n54\tO\n%\tO\n)\tO\npatients\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nRAPA\tB-Chemical\nconversion\tO\nprovides\tO\nadequate\tO\nimmunosuppression\tO\nto\tO\nenable\tO\nCsA\tB-Chemical\nwithdrawal\tO\n.\tO\n\nHowever\tO\n,\tO\nwhen\tO\nconverting\tO\npatients\tO\nto\tO\nRAPA\tB-Chemical\ndrug\tO\nlevels\tO\nshould\tO\nbe\tO\nmonitored\tO\nto\tO\navoid\tO\nover\tO\n-\tO\nimmunosuppression\tO\nand\tO\nadequate\tO\nantiviral\tO\nand\tO\nPneumocystis\tB-Disease\ncarinii\tI-Disease\npneumonia\tI-Disease\nprophylaxis\tO\nshould\tO\nbe\tO\ngiven\tO\n.\tO\n\nElectro\tO\n-\tO\noculography\tO\n,\tO\nelectroretinography\tO\n,\tO\nvisual\tO\nevoked\tO\npotentials\tO\n,\tO\nand\tO\nmultifocal\tO\nelectroretinography\tO\nin\tO\npatients\tO\nwith\tO\nvigabatrin\tB-Chemical\n-\tO\nattributed\tO\nvisual\tB-Disease\nfield\tI-Disease\nconstriction\tI-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nSymptomatic\tO\nvisual\tB-Disease\nfield\tI-Disease\nconstriction\tI-Disease\nthought\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nvigabatrin\tB-Chemical\nhas\tO\nbeen\tO\nreported\tO\n.\tO\n\nThe\tO\ncurrent\tO\nstudy\tO\ninvestigated\tO\nthe\tO\nvisual\tO\nfields\tO\nand\tO\nvisual\tO\nelectrophysiology\tO\nof\tO\neight\tO\npatients\tO\nwith\tO\nknown\tO\nvigabatrin\tB-Chemical\n-\tO\nattributed\tO\nvisual\tB-Disease\nfield\tI-Disease\nloss\tI-Disease\n,\tO\nthree\tO\nof\tO\nwhom\tO\nwere\tO\nreported\tO\npreviously\tO\n.\tO\n\nSix\tO\nof\tO\nthe\tO\npatients\tO\nwere\tO\nno\tO\nlonger\tO\nreceiving\tO\nvigabatrin\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\ncentral\tO\nand\tO\nperipheral\tO\nfields\tO\nwere\tO\nexamined\tO\nwith\tO\nthe\tO\nHumphrey\tO\nVisual\tO\nField\tO\nAnalyzer\tO\n.\tO\n\nFull\tO\nvisual\tO\nelectrophysiology\tO\n,\tO\nincluding\tO\nflash\tO\nelectroretinography\tO\n(\tO\nERG\tO\n)\tO\n,\tO\npattern\tO\nelectroretinography\tO\n,\tO\nmultifocal\tO\nERG\tO\nusing\tO\nthe\tO\nVERIS\tO\nsystem\tO\n,\tO\nelectro\tO\n-\tO\noculography\tO\n,\tO\nand\tO\nflash\tO\nand\tO\npattern\tO\nvisual\tO\nevoked\tO\npotentials\tO\n,\tO\nwas\tO\nundertaken\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSeven\tO\npatients\tO\nshowed\tO\nmarked\tO\nvisual\tB-Disease\nfield\tI-Disease\nconstriction\tI-Disease\nwith\tO\nsome\tO\nsparing\tO\nof\tO\nthe\tO\ntemporal\tO\nvisual\tO\nfield\tO\n.\tO\n\nThe\tO\neighth\tO\nexhibited\tO\nconcentric\tO\nconstriction\tO\n.\tO\n\nMost\tO\nelectrophysiological\tO\nresponses\tO\nwere\tO\nusually\tO\njust\tO\nwithin\tO\nnormal\tO\nlimits\tO\n;\tO\ntwo\tO\npatients\tO\nhad\tO\nsubnormal\tO\nArden\tO\nelectro\tO\n-\tO\noculography\tO\nindices\tO\n;\tO\nand\tO\none\tO\npatient\tO\nshowed\tO\nan\tO\nabnormally\tO\ndelayed\tO\nphotopic\tO\nb\tO\nwave\tO\n.\tO\n\nHowever\tO\n,\tO\nfive\tO\npatients\tO\nshowed\tO\ndelayed\tO\n30\tO\n-\tO\nHz\tO\nflicker\tO\nb\tO\nwaves\tO\n,\tO\nand\tO\nseven\tO\npatients\tO\nshowed\tO\ndelayed\tO\noscillatory\tO\npotentials\tO\n.\tO\n\nMultifocal\tO\nERG\tO\nshowed\tO\nabnormalities\tO\nthat\tO\nsometimes\tO\ncorrelated\tO\nwith\tO\nthe\tO\nvisual\tO\nfield\tO\nappearance\tO\nand\tO\nconfirmed\tO\nthat\tO\nthe\tO\ndeficit\tO\noccurs\tO\nat\tO\nthe\tO\nretinal\tO\nlevel\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nMarked\tO\nvisual\tB-Disease\nfield\tI-Disease\nconstriction\tI-Disease\nappears\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nvigabatrin\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\nfield\tO\ndefects\tO\nand\tO\nsome\tO\nelectrophysiological\tO\nabnormalities\tO\npersist\tO\nwhen\tO\nvigabatrin\tB-Chemical\ntherapy\tO\nis\tO\nwithdrawn\tO\n.\tO\n\nMyocardial\tB-Disease\nischemia\tI-Disease\ndue\tO\nto\tO\ncoronary\tB-Disease\nartery\tI-Disease\nspasm\tI-Disease\nduring\tO\ndobutamine\tB-Chemical\nstress\tO\nechocardiography\tO\n.\tO\n\nDobutamine\tB-Chemical\nstress\tO\nechocardiography\tO\n(\tO\nDSE\tO\n)\tO\nis\tO\na\tO\nuseful\tO\nand\tO\nsafe\tO\nprovocation\tO\ntest\tO\nfor\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n.\tO\n\nUntil\tO\nnow\tO\n,\tO\nthe\tO\ntest\tO\nhas\tO\nbeen\tO\nfocused\tO\nonly\tO\non\tO\nthe\tO\norganic\tO\nlesion\tO\nin\tO\nthe\tO\ncoronary\tO\nartery\tO\n,\tO\nand\tO\npositive\tO\nDSE\tO\nhas\tO\nindicated\tO\nthe\tO\npresence\tO\nof\tO\nsignificant\tO\nfixed\tO\ncoronary\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nis\tO\nto\tO\nexamine\tO\nwhether\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\ndue\tO\nto\tO\ncoronary\tB-Disease\nspasm\tI-Disease\nis\tO\ninduced\tO\nby\tO\ndobutamine\tB-Chemical\n.\tO\n\nWe\tO\nperformed\tO\nDSE\tO\non\tO\n51\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nspastic\tI-Disease\nangina\tI-Disease\nbut\tO\nwithout\tO\nsignificant\tO\nfixed\tO\ncoronary\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\n.\tO\n\nAll\tO\npatients\tO\nhad\tO\nanginal\tB-Disease\nattacks\tO\nat\tO\nrest\tO\nwith\tO\nST\tO\nelevation\tO\non\tO\nthe\tO\nelectrocardiogram\tO\n(\tO\nvariant\tB-Disease\nangina\tI-Disease\n)\tO\n.\tO\n\nCoronary\tO\nspasm\tO\nwas\tO\ninduced\tO\nby\tO\nintracoronary\tO\ninjection\tO\nof\tO\nacetylcholine\tB-Chemical\n,\tO\nand\tO\nno\tO\nfixed\tO\ncoronary\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\nwas\tO\ndocumented\tO\non\tO\nangiograms\tO\nin\tO\nall\tO\npatients\tO\n.\tO\n\nDSE\tO\nwas\tO\nperformed\tO\nwith\tO\nintravenous\tO\ndobutamine\tB-Chemical\ninfusion\tO\nwith\tO\nan\tO\nincremental\tO\ndoses\tO\nof\tO\n5\tO\n,\tO\n10\tO\n,\tO\n20\tO\n,\tO\n30\tO\n,\tO\nand\tO\n40\tO\nmicrog\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\nevery\tO\n5\tO\nminutes\tO\n.\tO\n\nOf\tO\nthe\tO\n51\tO\npatients\tO\n,\tO\n7\tO\npatients\tO\nshowed\tO\nasynergy\tO\nwith\tO\nST\tO\nelevation\tO\n.\tO\n\nAll\tO\n7\tO\npatients\tO\n(\tO\n13\tO\n.\tO\n7\tO\n%\tO\n)\tO\nhad\tO\nchest\tB-Disease\npain\tI-Disease\nduring\tO\nasynergy\tO\n,\tO\nand\tO\nboth\tO\nchest\tB-Disease\npain\tI-Disease\nand\tO\nelectrocardiographic\tO\nchanges\tO\nwere\tO\npreceded\tO\nby\tO\nasynergy\tO\n.\tO\n\nThese\tO\nfindings\tO\nindicate\tO\nthat\tO\ndobutamine\tB-Chemical\ncan\tO\nprovoke\tO\ncoronary\tB-Disease\nspasm\tI-Disease\nin\tO\nsome\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nspastic\tI-Disease\nangina\tI-Disease\n.\tO\n\nWhen\tO\nDSE\tO\nis\tO\nperformed\tO\nto\tO\nevaluate\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n,\tO\nnot\tO\nonly\tO\nfixed\tO\ncoronary\tB-Disease\nstenosis\tI-Disease\n,\tO\nbut\tO\nalso\tO\ncoronary\tB-Disease\nspasm\tI-Disease\nshould\tO\nbe\tO\nconsidered\tO\nas\tO\na\tO\ngenesis\tO\nof\tO\nasynergy\tO\n.\tO\n\nEffect\tO\nof\tO\nintravenous\tO\nmetoprolol\tB-Chemical\nor\tO\nintravenous\tO\nmetoprolol\tB-Chemical\nplus\tO\nglucagon\tO\non\tO\ndobutamine\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\neffect\tO\nof\tO\nmetoprolol\tB-Chemical\non\tO\ndobutamine\tB-Chemical\nstress\tO\ntesting\tO\nwith\tO\ntechnetium\tB-Chemical\n-\tI-Chemical\n99m\tI-Chemical\nsestamibi\tI-Chemical\nsingle\tO\n-\tO\nphoton\tO\nemission\tO\ncomputed\tO\ntomography\tO\nimaging\tO\nand\tO\nST\tO\n-\tO\nsegment\tO\nmonitoring\tO\n,\tO\nand\tO\nto\tO\nassess\tO\nthe\tO\nimpact\tO\nof\tO\nintravenous\tO\nglucagon\tO\non\tO\nmetoprolol\tB-Chemical\n'\tO\ns\tO\neffects\tO\n.\tO\n\nDESIGN\tO\n:\tO\nRandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrial\tO\n.\tO\n\nSETTING\tO\n:\tO\nCommunity\tO\nhospital\tO\n.\tO\n\nPATIENTS\tO\n:\tO\nTwenty\tO\n-\tO\ntwo\tO\npatients\tO\nwith\tO\nknown\tO\nreversible\tO\nperfusion\tO\ndefects\tO\n.\tO\n\nINTERVENTION\tO\n:\tO\nPatients\tO\nunderwent\tO\ndobutamine\tB-Chemical\nstress\tO\ntests\tO\nper\tO\nstandard\tO\nprotocol\tO\n.\tO\n\nBefore\tO\ndobutamine\tB-Chemical\nwas\tO\nbegun\tO\n,\tO\nno\tO\ntherapy\tO\nwas\tO\ngiven\tO\nduring\tO\nthe\tO\nfirst\tO\nvisit\tO\n,\tO\nand\tO\npatients\tO\nwere\tO\nrandomized\tO\non\tO\nsubsequent\tO\nvisits\tO\nto\tO\nreceive\tO\nmetoprolol\tB-Chemical\nor\tO\nmetoprolol\tB-Chemical\nplus\tO\nglucagon\tO\n1\tO\nmg\tO\n.\tO\n\nMetoprolol\tB-Chemical\nwas\tO\ndosed\tO\nto\tO\nachieve\tO\na\tO\nresting\tO\npredobutamine\tB-Chemical\nheart\tO\nrate\tO\nbelow\tO\n65\tO\nbeats\tO\n/\tO\nminute\tO\nor\tO\na\tO\ntotal\tO\nintravenous\tO\ndose\tO\nof\tO\n20\tO\nmg\tO\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nMetoprolol\tB-Chemical\nreduced\tO\nmaximum\tO\nheart\tO\nrate\tO\n31\tO\n%\tO\n,\tO\nsummed\tO\nstress\tO\nscores\tO\n29\tO\n%\tO\n,\tO\nand\tO\nsummed\tO\ndifference\tO\nscores\tO\n43\tO\n%\tO\nversus\tO\ncontrol\tO\n.\tO\n\nMetoprolol\tB-Chemical\nplus\tO\nglucagon\tO\nalso\tO\nreduced\tO\nthe\tO\nmaximum\tO\nheart\tO\nrate\tO\n29\tO\n%\tO\nversus\tO\ncontrol\tO\n.\tO\n\nSummed\tO\nstress\tO\nand\tO\nsummed\tO\ndifference\tO\nscores\tO\nwere\tO\nnot\tO\nsignificantly\tO\nreduced\tO\n,\tO\nalthough\tO\nthey\tO\nwere\tO\n18\tO\n%\tO\nand\tO\n30\tO\n%\tO\nlower\tO\n,\tO\nrespectively\tO\n,\tO\nthan\tO\ncontrol\tO\n.\tO\n\nNo\tO\nsignificant\tO\ndifferences\tO\nwere\tO\nfound\tO\nin\tO\nany\tO\nparameter\tO\nbetween\tO\nmetoprolol\tB-Chemical\nand\tO\nmetoprolol\tB-Chemical\n-\tO\nglucagon\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nDuring\tO\ndobutamine\tB-Chemical\nstress\tO\ntesting\tO\n,\tO\nmetoprolol\tB-Chemical\nattenuates\tO\nor\tO\neliminates\tO\nevidence\tO\nof\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n.\tO\n\nGlucagon\tO\n1\tO\nmg\tO\n,\tO\nalthough\tO\nsomewhat\tO\neffective\tO\n,\tO\ndoes\tO\nnot\tO\ncorrect\tO\nthis\tO\neffect\tO\nto\tO\nthe\tO\nextent\tO\nthat\tO\nit\tO\ncan\tO\nbe\tO\nadministered\tO\nclinically\tO\n.\tO\n\nEvidence\tO\nof\tO\nfunctional\tO\nsomatotopy\tO\nin\tO\nGPi\tO\nfrom\tO\nresults\tO\nof\tO\npallidotomy\tO\n.\tO\n\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexplore\tO\nthe\tO\nfunctional\tO\nanatomy\tO\nof\tO\nthe\tO\nglobus\tO\npallidus\tO\ninternus\tO\n(\tO\nGPi\tO\n)\tO\nby\tO\nstudying\tO\nthe\tO\neffects\tO\nof\tO\nunilateral\tO\npallidotomy\tO\non\tO\nparkinsonian\tB-Disease\n'\tO\noff\tO\n'\tO\nsigns\tO\nand\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n(\tO\nLID\tB-Disease\n)\tO\n.\tO\n\nWe\tO\nfound\tO\nsignificant\tO\npositive\tO\ncorrelations\tO\nbetween\tO\nthe\tO\npreoperative\tO\nlevodopa\tB-Chemical\nresponsiveness\tO\nof\tO\nmotor\tO\nsigns\tO\nand\tO\nthe\tO\nlevodopa\tB-Chemical\nresponsiveness\tO\nof\tO\nscores\tO\nin\tO\ntimed\tO\ntests\tO\n(\tO\nCore\tO\nAssessment\tO\nProgram\tO\nfor\tO\nIntracerebral\tO\nTransplantations\tO\n)\tO\nin\tO\nthe\tO\ncontralateral\tO\nlimbs\tO\nand\tO\nthe\tO\nimprovement\tO\nin\tO\nthese\tO\nscores\tO\nafter\tO\nsurgery\tO\n,\tO\nwhereas\tO\nthere\tO\nwas\tO\nno\tO\ncorrelation\tO\nwith\tO\nthe\tO\nimprovement\tO\nin\tO\nLID\tB-Disease\n.\tO\n\nWe\tO\nalso\tO\nfound\tO\na\tO\nhighly\tO\nsignificant\tO\ncorrelation\tO\n(\tO\nP\tO\n:\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n,\tO\nr\tO\n=\tO\n0\tO\n.\tO\n8\tO\n)\tO\nbetween\tO\nthe\tO\nvolume\tO\nof\tO\nthe\tO\nventral\tO\nlesion\tO\nin\tO\nthe\tO\nGPi\tO\nand\tO\nthe\tO\nimprovement\tO\nin\tO\nLID\tB-Disease\nin\tO\nthe\tO\ncontralateral\tO\nlimbs\tO\n,\tO\nwhereas\tO\nthere\tO\nwas\tO\nno\tO\ncorrelation\tO\nbetween\tO\nthe\tO\nventral\tO\nvolume\tO\nand\tO\nthe\tO\nimprovement\tO\nin\tO\nparkinsonian\tB-Disease\n'\tO\noff\tO\n'\tO\nsigns\tO\n.\tO\n\nThe\tO\nvolumes\tO\nof\tO\nthe\tO\ntotal\tO\nlesion\tO\ncylinder\tO\nand\tO\nthe\tO\ndorsal\tO\nlesion\tO\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nthe\tO\noutcome\tO\nof\tO\neither\tO\ndyskinesias\tB-Disease\nor\tO\nparkinsonian\tB-Disease\n'\tO\noff\tO\n'\tO\nsigns\tO\n.\tO\n\nThe\tO\ndifferential\tO\npredictive\tO\nvalue\tO\nof\tO\nlevodopa\tB-Chemical\nresponsiveness\tO\nfor\tO\nthe\tO\noutcome\tO\nof\tO\nparkinsonian\tB-Disease\n'\tO\noff\tO\n'\tO\nsigns\tO\nand\tO\nLID\tB-Disease\nand\tO\nthe\tO\ndifferent\tO\ncorrelations\tO\nof\tO\nventral\tO\nlesion\tO\nvolume\tO\nwith\tO\ndyskinesias\tB-Disease\nand\tO\nparkinsonian\tB-Disease\n'\tO\noff\tO\n'\tO\nsigns\tO\nindicate\tO\nthat\tO\ndifferent\tO\nanatomical\tO\nor\tO\npathophysiological\tO\nsubstrates\tO\nmay\tO\nbe\tO\nresponsible\tO\nfor\tO\nthe\tO\ngeneration\tO\nof\tO\nparkinsonian\tB-Disease\n'\tO\noff\tO\n'\tO\nsigns\tO\nand\tO\ndyskinesias\tB-Disease\n.\tO\n\nWhereas\tO\ncells\tO\nin\tO\na\tO\nwider\tO\narea\tO\nof\tO\nthe\tO\nGPi\tO\nmay\tO\nbe\tO\nimplicated\tO\nin\tO\nparkinsonism\tB-Disease\n,\tO\nthe\tO\nventral\tO\nGPi\tO\nseems\tO\nto\tO\nbe\tO\ncrucial\tO\nfor\tO\nthe\tO\nmanifestation\tO\nof\tO\nLID\tB-Disease\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\nour\tO\nobservations\tO\nare\tO\nadditional\tO\nproof\tO\nof\tO\nthe\tO\nfunctional\tO\nsomatotopy\tO\nof\tO\nthe\tO\nsystems\tO\nwithin\tO\nthe\tO\nGPi\tO\nthat\tO\nmediate\tO\nparkinsonism\tB-Disease\nand\tO\ndyskinesias\tB-Disease\n,\tO\nespecially\tO\nalong\tO\nthe\tO\ndorsoventral\tO\ntrajectory\tO\nused\tO\nin\tO\npallidotomy\tO\n.\tO\n\nThe\tO\noutcome\tO\nof\tO\npallidotomy\tO\nin\tO\nwhich\tO\nthe\tO\nlesion\tO\ninvolves\tO\nthe\tO\nventral\tO\nand\tO\ndorsal\tO\nGPi\tO\ncould\tO\nbe\tO\nthe\tO\nnet\tO\neffect\tO\nof\tO\nalteration\tO\nin\tO\nthe\tO\nactivity\tO\nof\tO\npathways\tO\nwhich\tO\nmediate\tO\ndifferent\tO\nsymptoms\tO\n,\tO\nand\tO\nhence\tO\ncould\tO\nbe\tO\nvariable\tO\n.\tO\n\nScreening\tO\nfor\tO\nstimulant\tO\nuse\tO\nin\tO\nadult\tO\nemergency\tO\ndepartment\tO\nseizure\tB-Disease\npatients\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\nprevalence\tO\nof\tO\npositive\tO\nplasma\tO\ndrug\tO\nscreening\tO\nfor\tO\ncocaine\tB-Chemical\nor\tO\namphetamine\tB-Chemical\nin\tO\nadult\tO\nemergency\tO\ndepartment\tO\nseizure\tB-Disease\npatients\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nprospective\tO\nstudy\tO\nevaluated\tO\nconsecutive\tO\neligible\tO\nseizure\tB-Disease\npatients\tO\nwho\tO\nhad\tO\na\tO\nplasma\tO\nsample\tO\ncollected\tO\nas\tO\npart\tO\nof\tO\ntheir\tO\nclinical\tO\nevaluation\tO\n.\tO\n\nPlasma\tO\nwas\tO\ntested\tO\nfor\tO\namphetamine\tB-Chemical\nand\tO\nthe\tO\ncocaine\tB-Chemical\nmetabolite\tO\nbenzoylecgonine\tB-Chemical\nusing\tO\nenzyme\tO\n-\tO\nmediated\tO\nimmunoassay\tO\nmethodology\tO\n.\tO\n\nPlasma\tO\nsamples\tO\nwith\tO\nbenzoylecgonine\tB-Chemical\ngreater\tO\nthan\tO\n150\tO\nng\tO\n/\tO\nmL\tO\nor\tO\nan\tO\namphetamine\tB-Chemical\ngreater\tO\nthan\tO\n500\tO\nng\tO\n/\tO\nmL\tO\nwere\tO\ndefined\tO\nas\tO\npositive\tO\n.\tO\n\nPatient\tO\ndemographics\tO\n,\tO\nhistory\tO\nof\tO\nunderlying\tO\ndrug\tO\nor\tO\nalcohol\tB-Chemical\n-\tO\nrelated\tO\nseizure\tB-Disease\ndisorder\tO\n,\tO\nestimated\tO\ntime\tO\nfrom\tO\nseizure\tB-Disease\nto\tO\nsample\tO\ncollection\tO\n,\tO\nhistory\tO\nor\tO\nsuspicion\tO\nof\tO\ncocaine\tB-Disease\nor\tI-Disease\namphetamine\tI-Disease\nabuse\tI-Disease\n,\tO\nresults\tO\nof\tO\nclinical\tO\nurine\tO\ntesting\tO\nfor\tO\ndrugs\tO\nof\tO\nabuse\tO\n,\tO\nand\tO\nassay\tO\nresults\tO\nwere\tO\nrecorded\tO\nwithout\tO\npatient\tO\nidentifiers\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFourteen\tO\nof\tO\n248\tO\n(\tO\n5\tO\n.\tO\n6\tO\n%\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n2\tO\n.\tO\n7\tO\n%\tO\n-\tO\n8\tO\n.\tO\n5\tO\n%\tO\n)\tO\nplasma\tO\nsamples\tO\nwere\tO\npositive\tO\nby\tO\nimmunoassay\tO\ntesting\tO\nfor\tO\nbenzoylecgonine\tB-Chemical\nand\tO\nno\tO\nsamples\tO\n(\tO\n0\tO\n%\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n-\tO\n1\tO\n.\tO\n2\tO\n%\tO\n)\tO\nwere\tO\npositive\tO\nfor\tO\namphetamine\tB-Chemical\n.\tO\n\nPositive\tO\ntest\tO\nresults\tO\nwere\tO\nmore\tO\ncommon\tO\nin\tO\npatient\tO\nvisits\tO\nwhere\tO\nthere\tO\nwas\tO\na\tO\nhistory\tO\nor\tO\nsuspicion\tO\nof\tO\ncocaine\tB-Disease\nor\tI-Disease\namphetamine\tI-Disease\nabuse\tI-Disease\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n0005\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDuring\tO\nthis\tO\nstudy\tO\nperiod\tO\n,\tO\nroutine\tO\nplasma\tO\nscreening\tO\nfor\tO\ncocaine\tB-Chemical\nand\tO\namphetamines\tB-Chemical\nin\tO\nadult\tO\nseizure\tB-Disease\npatients\tO\nhad\tO\na\tO\nlow\tO\nyield\tO\n.\tO\n\nAs\tO\na\tO\nresult\tO\n,\tO\nroutine\tO\nplasma\tO\nscreening\tO\nwould\tO\nyield\tO\nfew\tO\ncases\tO\nof\tO\nstimulant\tO\ndrug\tO\nin\tO\nwhich\tO\nthere\tO\nwas\tO\nneither\tO\na\tO\nhistory\tO\nnor\tO\nsuspicion\tO\nof\tO\ndrug\tB-Disease\nabuse\tI-Disease\nin\tO\nthis\tO\npopulation\tO\n.\tO\n\nContribution\tO\nof\tO\nsodium\tB-Chemical\nvalproate\tI-Chemical\nto\tO\nthe\tO\nsyndrome\tB-Disease\nof\tI-Disease\ninappropriate\tI-Disease\nsecretion\tI-Disease\nof\tI-Disease\nantidiuretic\tI-Disease\nhormone\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n62\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\nwas\tO\nadministered\tO\nsodium\tB-Chemical\nvalproate\tI-Chemical\n(\tO\nVPA\tB-Chemical\n)\tO\nand\tO\nwho\tO\nsubsequently\tO\ndeveloped\tO\nthe\tO\nsyndrome\tB-Disease\nof\tI-Disease\ninappropriate\tI-Disease\nsecretion\tI-Disease\nof\tI-Disease\nantidiuretic\tI-Disease\nhormone\tI-Disease\n(\tO\nSIADH\tB-Disease\n)\tO\n.\tO\n\nHe\tO\nhad\tO\nbeen\tO\ntaking\tO\nVPA\tB-Chemical\nfor\tO\ntreatment\tO\nof\tO\nidiopathic\tO\ngeneralized\tO\ntonic\tB-Disease\n-\tI-Disease\nclonic\tI-Disease\nconvulsions\tI-Disease\nsince\tO\nhe\tO\nwas\tO\n56\tO\nyears\tO\nold\tO\n.\tO\n\nAfter\tO\nsubstituting\tO\nVPA\tB-Chemical\nwith\tO\nzonisamide\tB-Chemical\n,\tO\nthe\tO\nserum\tO\nsodium\tB-Chemical\nlevel\tO\nreturned\tO\nto\tO\nnormal\tO\n.\tO\n\nWe\tO\nconsider\tO\nthis\tO\nepisode\tO\nof\tO\nSIADH\tB-Disease\nto\tO\nbe\tO\nthe\tO\nresult\tO\nof\tO\na\tO\ncombination\tO\nof\tO\nfactors\tO\nincluding\tO\na\tO\nweakness\tB-Disease\nof\tI-Disease\nthe\tI-Disease\ncentral\tI-Disease\nnervous\tI-Disease\nsystem\tI-Disease\nand\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nadministration\tO\nof\tO\nVPA\tB-Chemical\n.\tO\n\nAssociation\tO\nof\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nproduction\tO\nand\tO\napoptosis\tO\nin\tO\na\tO\nmodel\tO\nof\tO\nexperimental\tO\nnephropathy\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nIn\tO\nrecent\tO\nstudies\tO\nincreased\tO\namounts\tO\nof\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\nand\tO\napoptosis\tO\nhave\tO\nbeen\tO\nimplicated\tO\nin\tO\nvarious\tO\npathological\tO\nconditions\tO\nin\tO\nthe\tO\nkidney\tO\n.\tO\n\nWe\tO\nhave\tO\nstudied\tO\nthe\tO\nrole\tO\nof\tO\nNO\tB-Chemical\nand\tO\nits\tO\nassociation\tO\nwith\tO\napoptosis\tO\nin\tO\nan\tO\nexperimental\tO\nmodel\tO\nof\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\ninduced\tO\nby\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\nadriamycin\tB-Chemical\n(\tO\nADR\tB-Chemical\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nalteration\tO\nin\tO\nthe\tO\nNO\tB-Chemical\npathway\tO\nwas\tO\nassessed\tO\nby\tO\nmeasuring\tO\nnitrite\tB-Chemical\nlevels\tO\nin\tO\nserum\tO\n/\tO\nurine\tO\nand\tO\nby\tO\nevaluating\tO\nthe\tO\nchanges\tO\nin\tO\nvascular\tO\nreactivity\tO\nof\tO\nthe\tO\nisolated\tO\nperfused\tO\nrat\tO\nkidney\tO\n(\tO\nIPRK\tO\n)\tO\nsystem\tO\n.\tO\n\nRats\tO\nwere\tO\nstratified\tO\ninto\tO\ncontrol\tO\ngroups\tO\nand\tO\nADR\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\ngroups\tO\n.\tO\n\nThese\tO\ntwo\tO\ngroups\tO\nwere\tO\nthen\tO\ndivided\tO\ninto\tO\n:\tO\ngroup\tO\n1\tO\n,\tO\nanimals\tO\nreceiving\tO\nsaline\tO\n;\tO\nand\tO\ngroup\tO\n2\tO\n,\tO\nanimals\tO\nreceiving\tO\naminoguanidine\tB-Chemical\n(\tO\nAG\tB-Chemical\n)\tO\nwhich\tO\nis\tO\na\tO\nspecific\tO\ninhibitor\tO\nof\tO\ninducible\tO\n-\tO\nNO\tB-Chemical\nsynthase\tO\n.\tO\n\nOn\tO\nday\tO\n21\tO\n,\tO\nrats\tO\nwere\tO\nsacrificed\tO\nafter\tO\nobtaining\tO\nmaterial\tO\nfor\tO\nbiochemical\tO\nanalysis\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHistopathological\tO\nexamination\tO\nof\tO\nthe\tO\nkidneys\tO\nof\tO\nrats\tO\ntreated\tO\nwith\tO\nADR\tB-Chemical\nrevealed\tO\nfocal\tO\nareas\tO\nof\tO\nmesangial\tB-Disease\nproliferation\tI-Disease\nand\tO\nmild\tO\ntubulointerstitial\tB-Disease\ninflammation\tI-Disease\n.\tO\n\nThey\tO\nalso\tO\nhad\tO\nsignificantly\tO\nhigher\tO\nlevels\tO\nof\tO\nproteinuria\tB-Disease\ncompared\tO\nwith\tO\ncontrol\tO\nand\tO\ntreatment\tO\ngroups\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nUrine\tO\nnitrite\tB-Chemical\nlevels\tO\nwere\tO\nsignificantly\tO\nincreased\tO\nin\tO\nthe\tO\nADR\tB-Chemical\n-\tO\nnephropathy\tB-Disease\ngroup\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\nIPRK\tO\nphenylephrine\tB-Chemical\nand\tO\nacetylcholine\tB-Chemical\nrelated\tO\nresponses\tO\nwere\tO\nsignificantly\tO\nimpaired\tO\nin\tO\nthe\tO\nADR\tB-Chemical\n-\tO\nnephropathy\tB-Disease\ngroup\tO\n.\tO\n\nApoptosis\tO\nwas\tO\nnot\tO\ndetected\tO\nin\tO\ncontrols\tO\n.\tO\n\nHowever\tO\n,\tO\nin\tO\nthe\tO\nADR\tB-Chemical\n-\tO\nnephropathy\tB-Disease\ngroup\tO\n,\tO\nnumerous\tO\napoptotic\tO\ncells\tO\nwere\tO\nidentified\tO\nin\tO\nthe\tO\ntubulointerstitial\tO\nareas\tO\n.\tO\n\nDouble\tO\nstaining\tO\nrevealed\tO\nnumerous\tO\ninterstitial\tO\napoptotic\tO\ncells\tO\nto\tO\nstain\tO\nfor\tO\nED1\tO\n,\tO\na\tO\nmarker\tO\nfor\tO\nmonocytes\tO\n/\tO\nmacrophages\tO\n.\tO\n\nTreatment\tO\nwith\tO\nAG\tB-Chemical\nprevented\tO\nthe\tO\nimpairment\tO\nof\tO\nrenal\tO\nvascular\tO\nbed\tO\nresponses\tO\nand\tO\nreduced\tO\nboth\tO\nurine\tO\nnitrite\tB-Chemical\nlevels\tO\nand\tO\napoptosis\tO\nto\tO\ncontrol\tO\nlevels\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nWe\tO\nsuggest\tO\nthat\tO\ninteractions\tO\nbetween\tO\nNO\tB-Chemical\nand\tO\napoptosis\tO\nare\tO\nimportant\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nthe\tO\nADR\tB-Chemical\n-\tO\ninduced\tO\nnephrosis\tB-Disease\n.\tO\n\nDual\tO\neffects\tO\nof\tO\nmelatonin\tB-Chemical\non\tO\nbarbiturate\tB-Chemical\n-\tO\ninduced\tO\nnarcosis\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nMelatonin\tB-Chemical\naffects\tO\nthe\tO\ncircadian\tO\nsleep\tO\n/\tO\nwake\tO\ncycle\tO\n,\tO\nbut\tO\nit\tO\nis\tO\nnot\tO\nclear\tO\nwhether\tO\nit\tO\nmay\tO\ninfluence\tO\ndrug\tO\n-\tO\ninduced\tO\nnarcosis\tB-Disease\n.\tO\n\nSodium\tB-Chemical\nthiopenthal\tI-Chemical\nwas\tO\nadministered\tO\nintraperitoneally\tO\ninto\tO\nmale\tO\nrats\tO\npre\tO\n-\tO\ntreated\tO\nwith\tO\nmelatonin\tB-Chemical\n(\tO\n0\tO\n.\tO\n05\tO\n,\tO\n0\tO\n.\tO\n5\tO\n,\tO\n5\tO\nand\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nMelatonin\tB-Chemical\npre\tO\n-\tO\ntreatment\tO\naffected\tO\nin\tO\na\tO\ndual\tO\nmanner\tO\nbarbiturate\tB-Chemical\nnarcosis\tB-Disease\n,\tO\nhowever\tO\n,\tO\nno\tO\ndose\tO\n-\tO\neffect\tO\ncorrelation\tO\nwas\tO\nfound\tO\n.\tO\n\nIn\tO\nparticular\tO\n,\tO\nlow\tO\ndoses\tO\nreduced\tO\nthe\tO\nlatency\tO\nto\tO\nand\tO\nprolonged\tO\nthe\tO\nduration\tO\nof\tO\nbarbiturate\tB-Chemical\nnarcosis\tB-Disease\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthe\tO\nhighest\tO\ndose\tO\nof\tO\nmelatonin\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ncaused\tO\na\tO\nparadoxical\tO\nincrease\tO\nin\tO\nthe\tO\nlatency\tO\nand\tO\nproduced\tO\na\tO\nsustained\tO\nreduction\tO\nof\tO\nthe\tO\nduration\tO\nof\tO\nnarcosis\tB-Disease\n,\tO\nand\tO\na\tO\nreduction\tO\nin\tO\nmortality\tO\nrate\tO\n.\tO\n\nMelatonin\tB-Chemical\n0\tO\n.\tO\n5\tO\nand\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ninfluenced\tO\nthe\tO\nduration\tO\nbut\tO\nnot\tO\nthe\tO\nlatency\tO\nof\tO\nketamine\tB-Chemical\n-\tO\nor\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\nnarcosis\tB-Disease\n.\tO\n\nThus\tO\n,\tO\nthe\tO\ndual\tO\naction\tO\nof\tO\nmelatonin\tB-Chemical\non\tO\npharmacological\tO\nnarcosis\tB-Disease\nseems\tO\nto\tO\nbe\tO\nspecific\tO\nfor\tO\nthe\tO\nbarbiturate\tB-Chemical\nmechanism\tO\nof\tO\naction\tO\n.\tO\n\nReduced\tO\ncardiotoxicity\tB-Disease\nand\tO\npreserved\tO\nantitumor\tO\nefficacy\tO\nof\tO\nliposome\tO\n-\tO\nencapsulated\tO\ndoxorubicin\tB-Chemical\nand\tO\ncyclophosphamide\tB-Chemical\ncompared\tO\nwith\tO\nconventional\tO\ndoxorubicin\tB-Chemical\nand\tO\ncyclophosphamide\tB-Chemical\nin\tO\na\tO\nrandomized\tO\n,\tO\nmulticenter\tO\ntrial\tO\nof\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\ndetermine\tO\nwhether\tO\nMyocet\tB-Chemical\n(\tO\nliposome\tO\n-\tO\nencapsulated\tO\ndoxorubicin\tB-Chemical\n;\tO\nThe\tO\nLiposome\tO\nCompany\tO\n,\tO\nElan\tO\nCorporation\tO\n,\tO\nPrinceton\tO\n,\tO\nNJ\tO\n)\tO\nin\tO\ncombination\tO\nwith\tO\ncyclophosphamide\tB-Chemical\nsignificantly\tO\nreduces\tO\ndoxorubicin\tB-Chemical\ncardiotoxicity\tB-Disease\nwhile\tO\nproviding\tO\ncomparable\tO\nantitumor\tO\nefficacy\tO\nin\tO\nfirst\tO\n-\tO\nline\tO\ntreatment\tO\nof\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\n(\tO\nMBC\tB-Disease\n)\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nTwo\tO\nhundred\tO\nninety\tO\n-\tO\nseven\tO\npatients\tO\nwith\tO\nMBC\tB-Disease\nand\tO\nno\tO\nprior\tO\nchemotherapy\tO\nfor\tO\nmetastatic\tO\ndisease\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\neither\tO\n60\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nof\tO\nMyocet\tB-Chemical\n(\tO\nM\tO\n)\tO\nor\tO\nconventional\tO\ndoxorubicin\tB-Chemical\n(\tO\nA\tO\n)\tO\n,\tO\nin\tO\ncombination\tO\nwith\tO\n600\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nof\tO\ncyclophosphamide\tB-Chemical\n(\tO\nC\tO\n)\tO\n,\tO\nevery\tO\n3\tO\nweeks\tO\nuntil\tO\ndisease\tO\nprogression\tO\nor\tO\nunacceptable\tO\ntoxicity\tB-Disease\n.\tO\n\nCardiotoxicity\tB-Disease\nwas\tO\ndefined\tO\nby\tO\nreductions\tO\nin\tO\nleft\tO\n-\tO\nventricular\tO\nejection\tO\nfraction\tO\n,\tO\nassessed\tO\nby\tO\nserial\tO\nmultigated\tO\nradionuclide\tO\nangiography\tO\nscans\tO\n,\tO\nor\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n(\tO\nCHF\tB-Disease\n)\tO\n.\tO\n\nAntitumor\tO\nefficacy\tO\nwas\tO\nassessed\tO\nby\tO\nobjective\tO\ntumor\tB-Disease\nresponse\tO\nrates\tO\n(\tO\nWorld\tO\nHealth\tO\nOrganization\tO\ncriteria\tO\n)\tO\n,\tO\ntime\tO\nto\tO\nprogression\tO\n,\tO\nand\tO\nsurvival\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSix\tO\npercent\tO\nof\tO\nMC\tO\npatients\tO\nversus\tO\n21\tO\n%\tO\n(\tO\nincluding\tO\nfive\tO\ncases\tO\nof\tO\nCHF\tB-Disease\n)\tO\nof\tO\nAC\tO\npatients\tO\ndeveloped\tO\ncardiotoxicity\tB-Disease\n(\tO\nP\tO\n=\tO\n.\tO\n0002\tO\n)\tO\n.\tO\n\nMedian\tO\ncumulative\tO\ndoxorubicin\tB-Chemical\ndose\tO\nat\tO\nonset\tO\nwas\tO\nmore\tO\nthan\tO\n2\tO\n,\tO\n220\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\nMC\tO\nversus\tO\n480\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\nAC\tO\n(\tO\nP\tO\n=\tO\n.\tO\n0001\tO\n,\tO\nhazard\tO\nratio\tO\n,\tO\n5\tO\n.\tO\n04\tO\n)\tO\n.\tO\n\nMC\tO\npatients\tO\nalso\tO\nexperienced\tO\nless\tO\ngrade\tO\n4\tO\nneutropenia\tB-Disease\n.\tO\n\nAntitumor\tO\nefficacy\tO\nof\tO\nMC\tO\nversus\tO\nAC\tO\nwas\tO\ncomparable\tO\n:\tO\nobjective\tO\nresponse\tO\nrates\tO\n,\tO\n43\tO\n%\tO\nversus\tO\n43\tO\n%\tO\n;\tO\nmedian\tO\ntime\tO\nto\tO\nprogression\tO\n,\tO\n5\tO\n.\tO\n1\tO\n%\tO\nversus\tO\n5\tO\n.\tO\n5\tO\nmonths\tO\n;\tO\nmedian\tO\ntime\tO\nto\tO\ntreatment\tO\nfailure\tO\n,\tO\n4\tO\n.\tO\n6\tO\nversus\tO\n4\tO\n.\tO\n4\tO\nmonths\tO\n;\tO\nand\tO\nmedian\tO\nsurvival\tO\n,\tO\n19\tO\nversus\tO\n16\tO\nmonths\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nMyocet\tB-Chemical\nimproves\tO\nthe\tO\ntherapeutic\tO\nindex\tO\nof\tO\ndoxorubicin\tB-Chemical\nby\tO\nsignificantly\tO\nreducing\tO\ncardiotoxicity\tB-Disease\nand\tO\ngrade\tO\n4\tO\nneutropenia\tB-Disease\nand\tO\nprovides\tO\ncomparable\tO\nantitumor\tO\nefficacy\tO\n,\tO\nwhen\tO\nused\tO\nin\tO\ncombination\tO\nwith\tO\ncyclophosphamide\tB-Chemical\nas\tO\nfirst\tO\n-\tO\nline\tO\ntherapy\tO\nfor\tO\nMBC\tB-Disease\n.\tO\n\nThe\tO\nrole\tO\nof\tO\nnitrergic\tO\nsystem\tO\nin\tO\nlidocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsion\tB-Disease\nin\tO\nthe\tO\nmouse\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nN\tB-Chemical\n-\tI-Chemical\nnitro\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\nester\tI-Chemical\n(\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n)\tO\na\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\nsynthase\tO\ninhibitor\tO\nand\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n,\tO\na\tO\nNO\tB-Chemical\nprecursor\tO\n,\tO\nwere\tO\ninvestigated\tO\non\tO\nlidocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\nfirst\tO\nexperiment\tO\n,\tO\nfour\tO\ngroups\tO\nof\tO\nmice\tO\nreceived\tO\nphysiological\tO\nsaline\tO\n(\tO\n0\tO\n.\tO\n9\tO\n%\tO\n)\tO\n,\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n(\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n(\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nand\tO\ndiazepam\tB-Chemical\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nThirty\tO\nminutes\tO\nafter\tO\nthese\tO\ninjections\tO\n,\tO\nall\tO\nmice\tO\nreceived\tO\nlidocaine\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\nsecond\tO\nexperiment\tO\n,\tO\nfour\tO\ngroups\tO\nof\tO\nmice\tO\nreceived\tO\nsimilar\tO\ntreatment\tO\nin\tO\nthe\tO\nfirst\tO\nexperiment\tO\n,\tO\nand\tO\n30\tO\nmin\tO\nafter\tO\nthese\tO\ninjections\tO\n,\tO\nall\tO\nmice\tO\nreceived\tO\na\tO\nhigher\tO\ndose\tO\nof\tO\nlidocaine\tB-Chemical\n(\tO\n80\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n(\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nand\tO\ndiazepam\tB-Chemical\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nsignificantly\tO\ndecreased\tO\nthe\tO\nincidence\tO\nof\tO\nlidocaine\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthe\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntreatment\tO\nincreased\tO\nthe\tO\nincidence\tO\nof\tO\nlidocaine\tB-Chemical\n(\tO\n80\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nsignificantly\tO\n.\tO\n\nThese\tO\nresults\tO\nmay\tO\nsuggest\tO\nthat\tO\nNO\tB-Chemical\nis\tO\na\tO\nproconvulsant\tO\nmediator\tO\nin\tO\nlidocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nErythropoietin\tO\nrestores\tO\nthe\tO\nanemia\tB-Disease\n-\tO\ninduced\tO\nreduction\tO\nin\tO\ncyclophosphamide\tB-Chemical\ncytotoxicity\tB-Disease\nin\tO\nrat\tO\ntumors\tB-Disease\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\nimpact\tO\nof\tO\nanemia\tB-Disease\nprevention\tO\nby\tO\nrecombinant\tO\nhuman\tO\nerythropoietin\tO\n(\tO\nrHuEPO\tO\n)\tO\ntreatment\tO\non\tO\nthe\tO\ncytotoxicity\tB-Disease\nof\tO\ncyclophosphamide\tB-Chemical\nin\tO\nsolid\tO\nexperimental\tO\ntumors\tB-Disease\n.\tO\n\nAnemia\tB-Disease\nwas\tO\ninduced\tO\nusing\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\ncarboplatin\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nresulting\tO\nin\tO\na\tO\nlong\tO\n-\tO\nlasting\tO\nreduction\tO\n(\tO\n30\tO\n%\tO\n)\tO\nof\tO\nthe\tO\nhemoglobin\tO\nconcentration\tO\n.\tO\n\nIn\tO\na\tO\nsecond\tO\ngroup\tO\n,\tO\nthe\tO\ndevelopment\tO\nof\tO\nanemia\tB-Disease\nwas\tO\nprevented\tO\nby\tO\nrHuEPO\tO\n(\tO\n1000\tO\nIU\tO\n/\tO\nkg\tO\n)\tO\nadministered\tO\ns\tO\n.\tO\nc\tO\n.\tO\nthree\tO\ntimes\tO\n/\tO\nweek\tO\nstarting\tO\n7\tO\ndays\tO\nbefore\tO\ncarboplatin\tB-Chemical\napplication\tO\n.\tO\n\nFour\tO\ndays\tO\nafter\tO\ncarboplatin\tB-Chemical\ntreatment\tO\n,\tO\ntumors\tB-Disease\n(\tO\nDS\tO\n-\tO\nsarcoma\tB-Disease\nof\tO\nthe\tO\nrat\tO\n)\tO\nwere\tO\nimplanted\tO\ns\tO\n.\tO\nc\tO\n.\tO\nonto\tO\nthe\tO\nhind\tO\nfood\tO\ndorsum\tO\n.\tO\n\nNeither\tO\ncarboplatin\tB-Chemical\nnor\tO\nrHuEPO\tO\ntreatment\tO\ninfluenced\tO\ntumor\tB-Disease\ngrowth\tO\nrate\tO\nper\tO\nse\tO\n.\tO\n\nWhen\tO\ntumors\tB-Disease\nwere\tO\ntreated\tO\nwith\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\ncyclophosphamide\tB-Chemical\n(\tO\n60\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n5\tO\ndays\tO\nafter\tO\nimplantation\tO\n,\tO\na\tO\ngrowth\tO\ndelay\tO\nwith\tO\na\tO\nsubsequent\tO\nregrowth\tO\nof\tO\nthe\tO\ntumors\tB-Disease\nwas\tO\nobserved\tO\n.\tO\n\nIn\tO\nthe\tO\nanemia\tB-Disease\ngroup\tO\n,\tO\nthe\tO\ngrowth\tO\ndelay\tO\nwas\tO\nsignificantly\tO\nshorter\tO\ncompared\tO\nwith\tO\nnonanemic\tO\ncontrols\tO\n(\tO\n13\tO\n.\tO\n3\tO\ndays\tO\nversus\tO\n8\tO\n.\tO\n6\tO\ndays\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\ngroup\tO\nwhere\tO\nanemia\tB-Disease\nwas\tO\nprevented\tO\nby\tO\nrHuEPO\tO\ntreatment\tO\n,\tO\ngrowth\tO\ndelay\tO\nwas\tO\ncomparable\tO\nwith\tO\nthat\tO\nof\tO\nnonanemic\tO\ncontrols\tO\n(\tO\n13\tO\n.\tO\n3\tO\ndays\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nchemotherapy\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nreduces\tO\ncytotoxicity\tB-Disease\nof\tO\ncyclophosphamide\tB-Chemical\nin\tO\ntumors\tB-Disease\n,\tO\nwhereas\tO\ncorrection\tO\nof\tO\nanemia\tB-Disease\nby\tO\nrHuEPO\tO\ntreatment\tO\n(\tO\nepoetin\tO\nalpha\tO\n)\tO\nincreases\tO\nthe\tO\nsensitivity\tO\n,\tO\nprobably\tO\nas\tO\na\tO\nresult\tO\nof\tO\nan\tO\nimproved\tO\noxygen\tB-Chemical\nsupply\tO\nto\tO\ntumor\tB-Disease\ntissue\tO\n.\tO\n\nFatal\tO\nhaemorrhagic\tB-Disease\nmyocarditis\tI-Disease\nsecondary\tO\nto\tO\ncyclophosphamide\tB-Chemical\ntherapy\tO\n.\tO\n\nHaemorrhagic\tB-Disease\nmyocarditis\tI-Disease\nis\tO\na\tO\nrare\tO\nbut\tO\nimportant\tO\ncomplication\tO\nof\tO\ncyclophosphamide\tB-Chemical\ntherapy\tO\n.\tO\n\nEchocardiographic\tO\nidentification\tO\nof\tO\nthe\tO\ndisorder\tO\ncan\tO\nbe\tO\nmade\tO\n.\tO\n\nWe\tO\nbelieve\tO\nthat\tO\nthe\tO\nultrasound\tO\nfeatures\tO\nof\tO\nthis\tO\ndisorder\tO\nhave\tO\nnot\tO\nbeen\tO\npreviously\tO\nreported\tO\n.\tO\n\nEffects\tO\nof\tO\nverapamil\tB-Chemical\non\tO\natrial\tB-Disease\nfibrillation\tI-Disease\nand\tO\nits\tO\nelectrophysiological\tO\ndeterminants\tO\nin\tO\ndogs\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAtrial\tB-Disease\ntachycardia\tI-Disease\n-\tO\ninduced\tO\nremodeling\tO\npromotes\tO\nthe\tO\noccurrence\tO\nand\tO\nmaintenance\tO\nof\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n(\tO\nAF\tB-Disease\n)\tO\nand\tO\ndecreases\tO\nL\tO\n-\tO\ntype\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\ncurrent\tO\n.\tO\n\nThere\tO\nis\tO\nalso\tO\na\tO\nclinical\tO\nsuggestion\tO\nthat\tO\nacute\tO\nL\tO\n-\tO\ntype\tO\nCa\tB-Chemical\n(\tO\n2\tO\n)\tO\nchannel\tO\nblockade\tO\ncan\tO\npromote\tO\nAF\tB-Disease\n,\tO\nconsistent\tO\nwith\tO\nan\tO\nAF\tB-Disease\npromoting\tO\neffect\tO\nof\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nchannel\tO\ninhibition\tO\n.\tO\n\nMETHODS\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\npotential\tO\nmechanisms\tO\nof\tO\nAF\tB-Disease\npromotion\tO\nby\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nchannel\tO\nblockers\tO\n,\tO\nwe\tO\nadministered\tO\nverapamil\tB-Chemical\nto\tO\nmorphine\tB-Chemical\n-\tO\nchloralose\tB-Chemical\nanesthetized\tO\ndogs\tO\n.\tO\n\nDiltiazem\tB-Chemical\nwas\tO\nused\tO\nas\tO\na\tO\ncomparison\tO\ndrug\tO\nand\tO\nautonomic\tO\nblockade\tO\nwith\tO\natropine\tB-Chemical\nand\tO\nnadolol\tB-Chemical\nwas\tO\napplied\tO\nin\tO\nsome\tO\nexperiments\tO\n.\tO\n\nEpicardial\tO\nmapping\tO\nwith\tO\n240\tO\nepicardial\tO\nelectrodes\tO\nwas\tO\nused\tO\nto\tO\nevaluate\tO\nactivation\tO\nduring\tO\nAF\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nVerapamil\tB-Chemical\ncaused\tO\nAF\tB-Disease\npromotion\tO\nin\tO\nsix\tO\ndogs\tO\n,\tO\nincreasing\tO\nmean\tO\nduration\tO\nof\tO\nAF\tB-Disease\ninduced\tO\nby\tO\nburst\tO\npacing\tO\n,\tO\nfrom\tO\n8\tO\n+\tO\n/\tO\n-\tO\n4\tO\ns\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nS\tO\n.\tO\nE\tO\n.\tO\n)\tO\nto\tO\n95\tO\n+\tO\n/\tO\n-\tO\n39\tO\ns\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\nvs\tO\n.\tO\ncontrol\tO\n)\tO\nat\tO\na\tO\nloading\tO\ndose\tO\nof\tO\n0\tO\n.\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\nand\tO\n228\tO\n+\tO\n/\tO\n-\tO\n101\tO\ns\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0005\tO\nvs\tO\n.\tO\ncontrol\tO\n)\tO\nat\tO\na\tO\ndose\tO\nof\tO\n0\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nUnderlying\tO\nelectrophysiological\tO\nmechanisms\tO\nwere\tO\nstudied\tO\nin\tO\ndetail\tO\nin\tO\nfive\tO\nadditional\tO\ndogs\tO\nunder\tO\ncontrol\tO\nconditions\tO\nand\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nthe\tO\nhigher\tO\ndose\tO\nof\tO\nverapamil\tB-Chemical\n.\tO\n\nIn\tO\nthese\tO\nexperiments\tO\n,\tO\nverapamil\tB-Chemical\nshortened\tO\nmean\tO\neffective\tO\nrefractory\tO\nperiod\tO\n(\tO\nERP\tO\n)\tO\nfrom\tO\n122\tO\n+\tO\n/\tO\n-\tO\n5\tO\nto\tO\n114\tO\n+\tO\n/\tO\n-\tO\n4\tO\nms\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n02\tO\n)\tO\nat\tO\na\tO\ncycle\tO\nlength\tO\nof\tO\n300\tO\nms\tO\n,\tO\ndecreased\tO\nERP\tO\nheterogeneity\tO\n(\tO\nfrom\tO\n15\tO\n+\tO\n/\tO\n-\tO\n1\tO\nto\tO\n10\tO\n+\tO\n/\tO\n-\tO\n1\tO\n%\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nheterogeneously\tO\naccelerated\tO\natrial\tO\nconduction\tO\nand\tO\ndecreased\tO\nthe\tO\ncycle\tO\nlength\tO\nof\tO\nAF\tB-Disease\n(\tO\n94\tO\n+\tO\n/\tO\n-\tO\n4\tO\nto\tO\n84\tO\n+\tO\n/\tO\n-\tO\n3\tO\nms\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n005\tO\n)\tO\n.\tO\n\nDiltiazem\tB-Chemical\ndid\tO\nnot\tO\naffect\tO\nERP\tO\n,\tO\nAF\tB-Disease\ncycle\tO\nlength\tO\nor\tO\nAF\tB-Disease\nduration\tO\n,\tO\nbut\tO\nproduced\tO\nconduction\tO\nacceleration\tO\nsimilar\tO\nto\tO\nthat\tO\ncaused\tO\nby\tO\nverapamil\tB-Chemical\n(\tO\nn\tO\n=\tO\n5\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\npresence\tO\nof\tO\nautonomic\tO\nblockade\tO\n,\tO\nverapamil\tB-Chemical\nfailed\tO\nto\tO\npromote\tO\nAF\tB-Disease\nand\tO\nincreased\tO\n,\tO\nrather\tO\nthan\tO\ndecreasing\tO\n,\tO\nrefractoriness\tO\n.\tO\n\nNeither\tO\nverapamil\tB-Chemical\nnor\tO\ndiltiazem\tB-Chemical\naffected\tO\natrial\tO\nconduction\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nautonomic\tO\nblockade\tO\n.\tO\n\nEpicardial\tO\nmapping\tO\nsuggested\tO\nthat\tO\nverapamil\tB-Chemical\npromoted\tO\nAF\tB-Disease\nby\tO\nincreasing\tO\nthe\tO\nnumber\tO\nof\tO\nsimultaneous\tO\nwavefronts\tO\nreflected\tO\nby\tO\nseparate\tO\nzones\tO\nof\tO\nreactivation\tO\nin\tO\neach\tO\ncycle\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nVerapamil\tB-Chemical\npromotes\tO\nAF\tB-Disease\nin\tO\nnormal\tO\ndogs\tO\nby\tO\npromoting\tO\nmultiple\tO\ncircuit\tO\nreentry\tO\n,\tO\nan\tO\neffect\tO\ndependent\tO\non\tO\nintact\tO\nautonomic\tO\ntone\tO\nand\tO\nnot\tO\nshared\tO\nby\tO\ndiltiazem\tB-Chemical\n.\tO\n\nCalcitonin\tO\ngene\tO\n-\tO\nrelated\tO\npeptide\tO\nlevels\tO\nduring\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n-\tO\ninduced\tO\nheadache\tB-Disease\nin\tO\npatients\tO\nwith\tO\nchronic\tO\ntension\tB-Disease\n-\tI-Disease\ntype\tI-Disease\nheadache\tI-Disease\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nproposed\tO\nthat\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\ninduced\tO\nheadache\tB-Disease\nin\tO\nprimary\tB-Disease\nheadaches\tI-Disease\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nrelease\tO\nof\tO\ncalcitonin\tO\ngene\tO\n-\tO\nrelated\tO\npeptide\tO\n(\tO\nCGRP\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\nwe\tO\naimed\tO\nto\tO\ninvestigate\tO\nplasma\tO\nlevels\tO\nof\tO\nCGRP\tO\nduring\tO\nheadache\tB-Disease\ninduced\tO\nby\tO\nthe\tO\nNO\tB-Chemical\ndonor\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\n(\tO\nGTN\tB-Chemical\n)\tO\nin\tO\n16\tO\npatients\tO\nwith\tO\nchronic\tO\ntension\tB-Disease\n-\tI-Disease\ntype\tI-Disease\nheadache\tI-Disease\nand\tO\n16\tO\nhealthy\tO\ncontrols\tO\n.\tO\n\nThe\tO\nsubjects\tO\nwere\tO\nrandomly\tO\nallocated\tO\nto\tO\nreceive\tO\n0\tO\n.\tO\n5\tO\nmicrog\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\nGTN\tB-Chemical\nor\tO\nplacebo\tO\nover\tO\n20\tO\nmin\tO\non\tO\ntwo\tO\nheadache\tB-Disease\n-\tO\nfree\tO\ndays\tO\n.\tO\n\nBlood\tO\nsamples\tO\nwere\tO\ncollected\tO\nat\tO\nbaseline\tO\n,\tO\n10\tO\n,\tO\n20\tO\nand\tO\n60\tO\nmin\tO\nafter\tO\nstart\tO\nof\tO\ninfusion\tO\n.\tO\n\nBoth\tO\npatients\tO\nand\tO\ncontrols\tO\ndeveloped\tO\nsignificantly\tO\nstronger\tO\nimmediate\tO\nheadache\tB-Disease\non\tO\nthe\tO\nGTN\tB-Chemical\nday\tO\nthan\tO\non\tO\nthe\tO\nplacebo\tO\nday\tO\nand\tO\nthe\tO\nheadache\tB-Disease\nwas\tO\nsignificantly\tO\nmore\tO\npronounced\tO\nin\tO\npatients\tO\nthan\tO\nin\tO\ncontrols\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\ndifference\tO\nbetween\tO\nthe\tO\narea\tO\nunder\tO\nthe\tO\nCGRP\tO\ncurve\tO\n(\tO\nAUCCGRP\tO\n)\tO\non\tO\nGTN\tB-Chemical\nvs\tO\n.\tO\nplacebo\tO\nday\tO\nin\tO\neither\tO\npatients\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n65\tO\n)\tO\nor\tO\ncontrols\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n48\tO\n)\tO\n.\tO\n\nThe\tO\nAUCCGRP\tO\nrecorded\tO\non\tO\nthe\tO\nGTN\tB-Chemical\nday\tO\ndid\tO\nnot\tO\ndiffer\tO\nbetween\tO\npatients\tO\nand\tO\ncontrols\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n36\tO\n)\tO\n.\tO\n\nBoth\tO\nin\tO\npatients\tO\nand\tO\ncontrols\tO\n,\tO\nCGRP\tO\nlevels\tO\nchanged\tO\nsignificantly\tO\nover\tO\ntime\tO\n,\tO\non\tO\nboth\tO\nthe\tO\nGTN\tB-Chemical\nand\tO\nplacebo\tO\ndays\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nindicates\tO\nthat\tO\nNO\tB-Chemical\n-\tO\ninduced\tO\nimmediate\tO\nheadache\tB-Disease\nis\tO\nnot\tO\nassociated\tO\nwith\tO\nrelease\tO\nof\tO\nCGRP\tO\n.\tO\n\nFluconazole\tB-Chemical\n-\tO\ninduced\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\npresent\tO\na\tO\ncase\tO\nof\tO\nfluconazole\tB-Chemical\n-\tO\nassociated\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\nTDP\tB-Disease\n)\tO\nand\tO\ndiscuss\tO\nfluconazole\tB-Chemical\n'\tO\ns\tO\nrole\tO\nin\tO\ncausing\tO\nTDP\tB-Disease\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n68\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwhite\tO\nwoman\tO\nwith\tO\nCandida\tO\nglabrata\tO\nisolated\tO\nfrom\tO\na\tO\npresacral\tO\nabscess\tO\ndeveloped\tO\nTDP\tB-Disease\neight\tO\ndays\tO\nafter\tO\ncommencing\tO\noral\tO\nfluconazole\tB-Chemical\nThe\tO\npatient\tO\nhad\tO\nno\tO\nother\tO\nrisk\tO\nfactors\tO\nfor\tO\nTDP\tB-Disease\n,\tO\nincluding\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n,\tO\ncardiomyopathy\tB-Disease\n,\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n,\tO\nand\tO\nelectrolyte\tO\nabnormalities\tO\nThere\tO\nwas\tO\na\tO\ntemporal\tO\nassociation\tO\nbetween\tO\nthe\tO\ninitiation\tO\nof\tO\nfluconazole\tB-Chemical\nand\tO\nTDP\tB-Disease\n.\tO\n\nThe\tO\nTDP\tB-Disease\nresolved\tO\nwhen\tO\nfluconazole\tB-Chemical\nwas\tO\ndiscontinued\tO\n;\tO\nhowever\tO\n,\tO\nthe\tO\npatient\tO\ncontinued\tO\nto\tO\nhave\tO\npremature\tB-Disease\nventricular\tI-Disease\ncontractions\tI-Disease\nand\tO\nnonsustained\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n(\tO\nNSVT\tB-Disease\n)\tO\nuntil\tO\nsix\tO\ndays\tO\nafter\tO\ndrug\tO\ncessation\tO\nDISCUSSION\tO\n:\tO\nUse\tO\nof\tO\nthe\tO\nNaranjo\tO\nprobability\tO\nscale\tO\nindicates\tO\na\tO\nprobable\tO\nrelationship\tO\nbetween\tO\nthe\tO\nuse\tO\nof\tO\nfluconazole\tB-Chemical\nand\tO\nthe\tO\ndevelopment\tO\nof\tO\nTDP\tB-Disease\n.\tO\n\nThe\tO\npossible\tO\nmechanism\tO\nis\tO\ndepression\tB-Disease\nof\tO\nrapidly\tO\nactivating\tO\ndelayed\tO\nrectifier\tO\npotassium\tB-Chemical\ncurrents\tO\n.\tO\n\nIn\tO\nour\tO\npatient\tO\n,\tO\nthere\tO\nwas\tO\nno\tO\nother\tO\netiology\tO\nidentified\tO\nthat\tO\ncould\tO\nexplain\tO\nQT\tB-Disease\nprolongation\tI-Disease\nor\tO\nTDP\tB-Disease\nThe\tO\ncomplete\tO\ndisappearance\tO\nof\tO\nNSVT\tB-Disease\nand\tO\npremature\tB-Disease\nventricular\tI-Disease\ncontractions\tI-Disease\nfollowed\tO\nby\tO\nnormalization\tO\nof\tO\nQT\tO\ninterval\tO\nafter\tO\nthe\tO\ndrug\tO\nwas\tO\nstopped\tO\nstrongly\tO\nsuggests\tO\nfluconazole\tB-Chemical\nas\tO\nthe\tO\netiology\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nClinicians\tO\nshould\tO\nbe\tO\naware\tO\nthat\tO\nfluconazole\tB-Chemical\n,\tO\neven\tO\nat\tO\nlow\tO\ndoses\tO\n,\tO\nmay\tO\ncause\tO\nprolongation\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nQT\tI-Disease\ninterval\tI-Disease\n,\tO\nleading\tO\nto\tO\nTDP\tB-Disease\n.\tO\n\nSerial\tO\nelectrocardiographic\tO\nmonitoring\tO\nmay\tO\nbe\tO\nconsidered\tO\nwhen\tO\nfluconazole\tB-Chemical\nis\tO\nadministered\tO\nin\tO\npatients\tO\nwho\tO\nare\tO\nat\tO\nrisk\tO\nfor\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\n.\tO\n\nCutaneous\tB-Disease\nleucocytoclastic\tI-Disease\nvasculitis\tI-Disease\nassociated\tO\nwith\tO\noxacillin\tB-Chemical\n.\tO\n\nA\tO\n67\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\nwas\tO\ntreated\tO\nwith\tO\noxacillin\tB-Chemical\nfor\tO\none\tO\nweek\tO\nbecause\tO\nof\tO\nStaphylococcus\tB-Disease\naureus\tI-Disease\nbacteremia\tI-Disease\n,\tO\ndeveloped\tO\nrenal\tB-Disease\nfailure\tI-Disease\nand\tO\ndiffuse\tO\n,\tO\nsymmetric\tO\n,\tO\npalpable\tO\npurpuric\tB-Disease\nlesions\tI-Disease\non\tO\nhis\tO\nfeet\tO\n.\tO\n\nNecrotic\tB-Disease\nblisters\tI-Disease\nwere\tO\nnoted\tO\non\tO\nhis\tO\nfingers\tO\n.\tO\n\nSkin\tO\nbiopsies\tO\nshowed\tO\nfindings\tO\ndiagnostic\tO\nof\tO\nleucocytoclastic\tB-Disease\nvasculitis\tI-Disease\n.\tO\n\nOxacillin\tB-Chemical\nwas\tO\ndiscontinued\tO\nand\tO\npatient\tO\nwas\tO\ntreated\tO\nwith\tO\ncorticosteroids\tB-Chemical\n.\tO\n\nThe\tO\nrash\tB-Disease\ndisappeared\tO\nafter\tO\nthree\tO\nweeks\tO\nand\tO\nrenal\tO\nfunction\tO\nreturned\tO\nto\tO\nnormal\tO\n.\tO\n\nLeucocytoclastic\tB-Disease\nvasculitis\tI-Disease\npresents\tO\nas\tO\npalpable\tO\npurpura\tB-Disease\nof\tO\nthe\tO\nlower\tO\nextremities\tO\noften\tO\naccompanied\tO\nby\tO\nabdominal\tB-Disease\npain\tI-Disease\n,\tO\narthralgia\tB-Disease\n,\tO\nand\tO\nrenal\tB-Disease\ninvolvement\tI-Disease\n.\tO\n\nEtiologic\tO\nfactors\tO\nor\tO\nassociated\tO\ndisorders\tO\ninclude\tO\ninfections\tB-Disease\n,\tO\nmedications\tO\n,\tO\ncollagen\tB-Disease\nvascular\tI-Disease\ndisease\tI-Disease\nand\tO\nneoplasia\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nin\tO\nhalf\tO\nof\tO\nthe\tO\ncases\tO\nno\tO\netiologic\tO\nfactor\tO\nis\tO\nidentified\tO\n.\tO\n\nUsually\tO\nit\tO\nis\tO\na\tO\nself\tO\n-\tO\nlimited\tO\ndisorder\tO\n,\tO\nbut\tO\ncorticosteroid\tB-Chemical\ntherapy\tO\nmay\tO\nbe\tO\nneeded\tO\nin\tO\nlife\tO\n-\tO\nthreatening\tO\ncases\tO\nsince\tO\nearly\tO\ntreatment\tO\nwith\tO\ncorticosteroids\tB-Chemical\nin\tO\nsevere\tO\ncases\tO\ncan\tO\nprevent\tO\ncomplications\tO\n.\tO\n\nOxacillin\tB-Chemical\nshould\tO\nbe\tO\nincluded\tO\namong\tO\nthe\tO\ndrugs\tO\nthat\tO\ncan\tO\ncause\tO\nleucocytoclastic\tB-Disease\nvasculitis\tI-Disease\n.\tO\n\nThe\tO\nrenal\tO\npathology\tO\nin\tO\na\tO\ncase\tO\nof\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\ndiabetes\tB-Disease\ninsipidus\tI-Disease\n.\tO\n\nA\tO\ncase\tO\nof\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\ndiabetes\tB-Disease\ninsipidus\tI-Disease\nis\tO\nreported\tO\n.\tO\n\nAt\tO\nnecropsy\tO\nmicroscopy\tO\nshoed\tO\nunique\tO\nand\tO\nextensive\tO\ndamage\tO\nto\tO\ncells\tO\nlining\tO\nthe\tO\ndistal\tO\nnephron\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\nthese\tO\nchanges\tO\nrepresent\tO\na\tO\nspecific\tO\ntoxic\tO\neffect\tO\nof\tO\nlithium\tB-Chemical\n,\tO\nreported\tO\nhere\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nman\tO\n.\tO\n\nCholestatic\tB-Disease\njaundice\tI-Disease\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nmetformin\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\npatient\tO\nwho\tO\ndeveloped\tO\ncholestatic\tB-Disease\njaundice\tI-Disease\nshortly\tO\nafter\tO\ninitiation\tO\nof\tO\ntreatment\tO\nwith\tO\nmetformin\tB-Chemical\nhydrochloride\tI-Chemical\n.\tO\n\nUltrasound\tO\nof\tO\nthe\tO\nliver\tO\nand\tO\nabdominal\tO\nCT\tO\nwere\tO\nnormal\tO\n.\tO\n\nAn\tO\nERCP\tO\nshowed\tO\nnormal\tO\nbiliary\tO\nanatomy\tO\n.\tO\n\nA\tO\npercutaneous\tO\nliver\tO\nbiopsy\tO\nwas\tO\nobtained\tO\nshowing\tO\nmarked\tO\ncholestasis\tB-Disease\n,\tO\nwith\tO\nportal\tO\nedema\tB-Disease\n,\tO\nductular\tO\nproliferation\tO\n,\tO\nand\tO\nacute\tO\ninflammation\tB-Disease\n.\tO\n\nMetformin\tB-Chemical\nhydrochloride\tI-Chemical\nwas\tO\ndiscontinued\tO\n,\tO\nand\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\njaundice\tB-Disease\nresolved\tO\nslowly\tO\nover\tO\na\tO\nperiod\tO\nof\tO\nseveral\tO\nmonths\tO\n.\tO\n\nGiven\tO\nthe\tO\nonset\tO\nof\tO\nhis\tO\njaundice\tB-Disease\n2\tO\nwk\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\nmetformin\tB-Chemical\n,\tO\nwe\tO\nbelieve\tO\nthat\tO\nthis\tO\ncase\tO\nrepresents\tO\nan\tO\nexample\tO\nof\tO\nmetformin\tB-Chemical\n-\tO\nassociated\tO\nhepatotoxicity\tB-Disease\n,\tO\nthe\tO\nfirst\tO\nsuch\tO\ncase\tO\nreported\tO\n.\tO\n\nSystemic\tO\ntoxicity\tB-Disease\nand\tO\nresuscitation\tO\nin\tO\nbupivacaine\tB-Chemical\n-\tO\n,\tO\nlevobupivacaine\tB-Chemical\n-\tO\n,\tO\nor\tO\nropivacaine\tB-Chemical\n-\tO\ninfused\tO\nrats\tO\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\nsystemic\tO\ntoxicity\tB-Disease\nof\tO\nbupivacaine\tB-Chemical\n,\tO\nlevobupivacaine\tB-Chemical\n,\tO\nand\tO\nropivacaine\tB-Chemical\nin\tO\nanesthetized\tO\nrats\tO\n.\tO\n\nWe\tO\nalso\tO\ncompared\tO\nthe\tO\nability\tO\nto\tO\nresuscitate\tO\nrats\tO\nafter\tO\nlethal\tO\ndoses\tO\nof\tO\nthese\tO\nlocal\tO\nanesthetics\tO\n.\tO\n\nBupivacaine\tB-Chemical\n,\tO\nlevobupivacaine\tB-Chemical\n,\tO\nor\tO\nropivacaine\tB-Chemical\nwas\tO\ninfused\tO\nat\tO\na\tO\nrate\tO\nof\tO\n2\tO\nmg\tO\n.\tO\n\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nmin\tO\n(\tO\n-\tO\n1\tO\n)\tO\nwhile\tO\nelectrocardiogram\tO\n,\tO\nelectroencephalogram\tO\n,\tO\nand\tO\narterial\tO\npressure\tO\nwere\tO\ncontinuously\tO\nmonitored\tO\n.\tO\n\nWhen\tO\nasystole\tB-Disease\nwas\tO\nrecorded\tO\n,\tO\ndrug\tO\ninfusion\tO\nwas\tO\nstopped\tO\nand\tO\na\tO\nresuscitation\tO\nsequence\tO\nwas\tO\nbegun\tO\n.\tO\n\nEpinephrine\tB-Chemical\n0\tO\n.\tO\n01\tO\nmg\tO\n/\tO\nkg\tO\nwas\tO\nadministered\tO\nat\tO\n1\tO\n-\tO\nmin\tO\nintervals\tO\nwhile\tO\nexternal\tO\ncardiac\tO\ncompressions\tO\nwere\tO\napplied\tO\n.\tO\n\nResuscitation\tO\nwas\tO\nconsidered\tO\nsuccessful\tO\nwhen\tO\na\tO\nsystolic\tO\narterial\tO\npressure\tO\n>\tO\nor\tO\n=\tO\n100\tO\nmm\tO\nHg\tO\nwas\tO\nachieved\tO\nwithin\tO\n5\tO\nmin\tO\n.\tO\n\nThe\tO\ncumulative\tO\ndoses\tO\nof\tO\nlevobupivacaine\tB-Chemical\nand\tO\nropivacaine\tB-Chemical\nthat\tO\nproduced\tO\nseizures\tB-Disease\nwere\tO\nsimilar\tO\nand\tO\nwere\tO\nlarger\tO\nthan\tO\nthose\tO\nof\tO\nbupivacaine\tB-Chemical\n.\tO\n\nThe\tO\ncumulative\tO\ndoses\tO\nof\tO\nlevobupivacaine\tB-Chemical\nthat\tO\nproduced\tO\ndysrhythmias\tB-Disease\nand\tO\nasystole\tB-Disease\nwere\tO\nsmaller\tO\nthan\tO\nthe\tO\ncorresponding\tO\ndoses\tO\nof\tO\nropivacaine\tB-Chemical\n,\tO\nbut\tO\nthey\tO\nwere\tO\nlarger\tO\nthan\tO\nthose\tO\nof\tO\nbupivacaine\tB-Chemical\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\nsuccessful\tO\nresuscitations\tO\ndid\tO\nnot\tO\ndiffer\tO\namong\tO\ngroups\tO\n.\tO\n\nHowever\tO\n,\tO\na\tO\nsmaller\tO\ndose\tO\nof\tO\nepinephrine\tB-Chemical\nwas\tO\nrequired\tO\nin\tO\nthe\tO\nRopivacaine\tB-Chemical\ngroup\tO\nthan\tO\nin\tO\nthe\tO\nother\tO\ngroups\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nthe\tO\nsystemic\tO\ntoxicity\tB-Disease\nof\tO\nlevobupivacaine\tB-Chemical\nis\tO\nintermediate\tO\nbetween\tO\nthat\tO\nof\tO\nropivacaine\tB-Chemical\nand\tO\nbupivacaine\tB-Chemical\nwhen\tO\nadministered\tO\nat\tO\nthe\tO\nsame\tO\nrate\tO\nand\tO\nthat\tO\nropivacaine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\narrest\tI-Disease\nappears\tO\nto\tO\nbe\tO\nmore\tO\nsusceptible\tO\nto\tO\ntreatment\tO\nthan\tO\nthat\tO\ninduced\tO\nby\tO\nbupivacaine\tB-Chemical\nor\tO\nlevobupivacaine\tB-Chemical\n.\tO\n\nAmphotericin\tB-Chemical\nB\tI-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nAIDS\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nmultiple\tO\nepisodes\tO\nof\tO\nseizure\tB-Disease\nactivity\tO\nin\tO\nan\tO\nAIDS\tB-Disease\npatent\tO\nfollowing\tO\namphotericin\tB-Chemical\nB\tI-Chemical\ninfusion\tO\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n46\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nAfrican\tO\n-\tO\nAmerican\tO\nman\tO\nexperienced\tO\nrecurrent\tO\ngrand\tB-Disease\nmal\tI-Disease\nseizures\tI-Disease\nduring\tO\nintravenous\tO\ninfusion\tO\nof\tO\namphotericin\tB-Chemical\nB\tI-Chemical\n,\tO\nthen\tO\npetit\tO\nmal\tO\nseizures\tB-Disease\nas\tO\nthe\tO\ninfusion\tO\nwas\tO\nstopped\tO\nand\tO\nthe\tO\ndrug\tO\nconcentrations\tO\ndecreased\tO\nwith\tO\ntime\tO\n.\tO\n\nThe\tO\npatients\tO\nconcurrent\tO\nmedications\tO\nincluded\tO\ndidanosine\tB-Chemical\n,\tO\nhydroxyzine\tB-Chemical\n,\tO\npromethazine\tB-Chemical\n,\tO\nhydrocortisone\tB-Chemical\n,\tO\nand\tO\nprochlorperazine\tB-Chemical\n.\tO\n\nDespite\tO\nadministration\tO\nof\tO\nphenytoin\tB-Chemical\nand\tO\nlorazepam\tB-Chemical\n,\tO\nthe\tO\nseizures\tB-Disease\npersisted\tO\nand\tO\noccurred\tO\nonly\tO\nduring\tO\namphotercin\tB-Chemical\nB\tI-Chemical\nadministration\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nAIDS\tB-Disease\nand\tO\ncryptococcal\tB-Disease\nmeningitis\tI-Disease\n,\tO\nboth\tO\nof\tO\nwhich\tO\nthe\tO\npatient\tO\nhad\tO\n,\tO\ncan\tO\npotentially\tO\ncause\tO\nseizures\tB-Disease\n.\tO\n\nThe\tO\npatient\tO\nhad\tO\na\tO\nhistory\tO\nof\tO\nalcohol\tB-Disease\nabuse\tI-Disease\n;\tO\nalcohol\tB-Chemical\nintake\tO\nas\tO\nwell\tO\nas\tO\nwithdrawal\tO\ncan\tO\nalso\tO\ncause\tO\nseizures\tB-Disease\n.\tO\n\nDidanosine\tB-Chemical\nalso\tO\nhas\tO\na\tO\npotential\tO\nfor\tO\ninducing\tO\nseizures\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nthese\tO\nother\tO\npotential\tO\ncauses\tO\nof\tO\nseizure\tB-Disease\nwere\tO\nruled\tO\nout\tO\n.\tO\n\nThe\tO\ntime\tO\ncourse\tO\nof\tO\nevents\tO\nsuggested\tO\nthat\tO\namphotericin\tB-Chemical\nB\tI-Chemical\nwas\tO\nthe\tO\ncause\tO\nof\tO\nthe\tO\nseizures\tB-Disease\nin\tO\nthis\tO\nAIDS\tB-Disease\npatient\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAmphotericin\tB-Chemical\nB\tI-Chemical\nseems\tO\nto\tO\nbe\tO\nthe\tO\nprobable\tO\ncause\tO\nof\tO\nthe\tO\nseizures\tB-Disease\n.\tO\n\nTo\tO\ndate\tO\n,\tO\nonly\tO\nthree\tO\ncases\tO\nof\tO\nseizures\tB-Disease\nassociated\tO\nwith\tO\namphotericin\tB-Chemical\nB\tI-Chemical\nhave\tO\nbeen\tO\nreported\tO\nin\tO\nthe\tO\nliterature\tO\n,\tO\nbut\tO\nhealthcare\tO\nproviders\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthe\tO\npotential\tO\nfor\tO\nthis\tO\nrare\tO\nadverse\tO\neffect\tO\n.\tO\n\nSirolimus\tB-Chemical\nand\tO\nmycophenolate\tB-Chemical\nmofetil\tI-Chemical\nfor\tO\ncalcineurin\tO\n-\tO\nfree\tO\nimmunosuppression\tO\nin\tO\nrenal\tO\ntransplant\tO\nrecipients\tO\n.\tO\n\nCalcineurin\tO\ninhibitors\tO\n,\tO\nsuch\tO\nas\tO\ncyclosporine\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\n,\tO\nhave\tO\nbeen\tO\navailable\tO\nfor\tO\nalmost\tO\n20\tO\nyears\tO\n.\tO\n\nAlthough\tO\nthese\tO\ndrugs\tO\nare\tO\nhighly\tO\neffective\tO\nand\tO\nrepresent\tO\nthe\tO\nmainstay\tO\nof\tO\ntransplant\tO\nimmunosuppression\tO\n,\tO\nthey\tO\nare\tO\nassociated\tO\nwith\tO\nacute\tO\nand\tO\nchronic\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nAcute\tO\nnephrotoxicity\tB-Disease\n,\tO\nwhich\tO\noccurs\tO\nin\tO\nthe\tO\nearly\tO\nperiod\tO\nafter\tO\ntransplantation\tO\n,\tO\nleads\tO\nto\tO\na\tO\nhigher\tO\nrate\tO\nof\tO\ndialysis\tO\n,\tO\nand\tO\nchronic\tO\nnephrotoxicity\tB-Disease\nmay\tO\neventually\tO\nresult\tO\nin\tO\ngraft\tO\nloss\tO\n.\tO\n\nAcute\tO\nand\tO\nchronic\tO\nnephrotoxicity\tB-Disease\nis\tO\nbecoming\tO\nmore\tO\ncommon\tO\nas\tO\nthe\tO\nuse\tO\nof\tO\nmarginal\tO\nkidneys\tO\nfor\tO\ntransplantation\tO\nincreases\tO\n.\tO\n\nTwo\tO\nrecently\tO\navailable\tO\nimmunosuppressive\tO\nagents\tO\n,\tO\nmycophenolate\tB-Chemical\nmofetil\tI-Chemical\nand\tO\nsirolimus\tB-Chemical\n(\tO\nrapamycin\tB-Chemical\n)\tO\n,\tO\nhave\tO\nno\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nThe\tO\nuse\tO\nof\tO\nthese\tO\ndrugs\tO\nin\tO\ncombination\tO\nwith\tO\nother\tO\nagents\tO\nhas\tO\nled\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\nnew\tO\nparadigms\tO\nof\tO\nimmunosuppressive\tO\ntherapy\tO\n.\tO\n\nThis\tO\npaper\tO\nreviews\tO\nthe\tO\nresults\tO\nof\tO\nclinical\tO\ntrials\tO\nthat\tO\nhave\tO\ninvestigated\tO\nthese\tO\nnew\tO\napproaches\tO\nto\tO\nimmunosuppression\tO\nin\tO\nrenal\tO\ntransplant\tO\nrecipients\tO\n.\tO\n\nTolerability\tO\nof\tO\nnimesulide\tB-Chemical\nand\tO\nparacetamol\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nNSAID\tB-Chemical\n-\tO\ninduced\tO\nurticaria\tB-Disease\n/\tO\nangioedema\tB-Disease\n.\tO\n\nPrevious\tO\nstudies\tO\nevaluated\tO\nthe\tO\ntolerance\tO\nof\tO\nnimesulide\tB-Chemical\nand\tO\nparacetamol\tB-Chemical\nin\tO\nsubjects\tO\nwith\tO\ncutaneous\tO\n,\tO\nrespiratory\tO\nand\tO\nanaphylactoid\tO\nreactions\tO\ninduced\tO\nby\tO\nnonsteroidal\tB-Chemical\nanti\tI-Chemical\n-\tI-Chemical\ninflammatory\tI-Chemical\ndrugs\tI-Chemical\n(\tO\nNSAIDs\tB-Chemical\n)\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\nwe\tO\ninvestigated\tO\ntolerability\tO\nand\tO\nreliability\tO\nof\tO\nnimesulide\tB-Chemical\nand\tO\nparacetamol\tB-Chemical\nin\tO\na\tO\nvery\tO\nlarge\tO\nnumber\tO\nof\tO\npatients\tO\nwith\tO\nan\tO\nexclusive\tO\nwell\tO\n-\tO\ndocumented\tO\nhistory\tO\nof\tO\nNSAID\tB-Chemical\n-\tO\ninduced\tO\nurticaria\tB-Disease\n/\tO\nangioedema\tB-Disease\n.\tO\n\nFurthermore\tO\n,\tO\nwe\tO\nevaluated\tO\nwhether\tO\nsome\tO\nfactors\tO\nhave\tO\nthe\tO\npotential\tO\nto\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nreaction\tO\nto\tO\nparacetamol\tB-Chemical\nand\tO\nnimesulide\tB-Chemical\n.\tO\n\nA\tO\nsingle\tO\n-\tO\nplacebo\tO\n-\tO\ncontrolled\tO\noral\tO\nchallenge\tO\nprocedure\tO\nwith\tO\nnimesulide\tB-Chemical\nor\tO\nparacetamol\tB-Chemical\nwas\tO\napplied\tO\nto\tO\n829\tO\npatients\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nNSAID\tB-Chemical\n-\tO\ninduced\tO\nurticaria\tB-Disease\n/\tO\nangioedema\tB-Disease\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n75\tO\n/\tO\n829\tO\n(\tO\n9\tO\n.\tO\n4\tO\n%\tO\n)\tO\npatients\tO\nexperienced\tO\nreactions\tO\nto\tO\nnimesulide\tB-Chemical\nor\tO\nparacetamol\tB-Chemical\n.\tO\n\nOf\tO\nthe\tO\n715\tO\npatients\tO\ntested\tO\nwith\tO\nnimesulide\tB-Chemical\n62\tO\n(\tO\n8\tO\n.\tO\n6\tO\n%\tO\n)\tO\nshowed\tO\na\tO\npositive\tO\ntest\tO\n,\tO\nwhile\tO\nof\tO\n114\tO\nsubjects\tO\nsubmitted\tO\nto\tO\nthe\tO\nchallenge\tO\nwith\tO\nparacetamol\tB-Chemical\n,\tO\n13\tO\n(\tO\n9\tO\n.\tO\n6\tO\n%\tO\n)\tO\ndid\tO\nnot\tO\ntolerate\tO\nthis\tO\ndrug\tO\n.\tO\n\nFurthermore\tO\n,\tO\n18\tO\n.\tO\n28\tO\n%\tO\nof\tO\npatients\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nchronic\tO\nurticaria\tB-Disease\nand\tO\n11\tO\n.\tO\n8\tO\n%\tO\nof\tO\nsubjects\tO\nwith\tO\nan\tO\nhistory\tO\nof\tO\nNSAID\tB-Chemical\n-\tO\ninduced\tO\nurticaria\tB-Disease\n/\tO\nangioedema\tB-Disease\nor\tO\nangioedema\tB-Disease\nalone\tO\n(\tO\nwith\tO\nor\tO\nwithout\tO\nchronic\tO\nurticaria\tB-Disease\n)\tO\nresulted\tO\nto\tO\nbe\tO\nintolerant\tO\nto\tO\nalternative\tO\ndrugs\tO\n.\tO\n\nTaken\tO\ntogether\tO\n,\tO\nour\tO\nresults\tO\nconfirm\tO\nthe\tO\ngood\tO\ntolerability\tO\nof\tO\nnimesulide\tB-Chemical\nand\tO\nparacetamol\tB-Chemical\nin\tO\npatients\tO\nwho\tO\nexperienced\tO\nurticaria\tB-Disease\n/\tO\nangioedema\tB-Disease\ncaused\tO\nby\tO\nNSAIDs\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nrisk\tO\nof\tO\nreaction\tO\nto\tO\nthese\tO\nalternative\tO\nstudy\tO\ndrugs\tO\nis\tO\nstatistically\tO\nincreased\tO\nby\tO\na\tO\nhistory\tO\nof\tO\nchronic\tO\nurticaria\tB-Disease\nand\tO\n,\tO\nabove\tO\nall\tO\n,\tO\nby\tO\na\tO\nhistory\tO\nof\tO\nNSAID\tB-Chemical\n-\tO\ninduced\tO\nangioedema\tB-Disease\n.\tO\n\nComparison\tO\nof\tO\naqueous\tO\nand\tO\ngellan\tO\nophthalmic\tO\ntimolol\tB-Chemical\nwith\tO\nplacebo\tO\non\tO\nthe\tO\n24\tO\n-\tO\nhour\tO\nheart\tO\nrate\tO\nresponse\tO\nin\tO\npatients\tO\non\tO\ntreatment\tO\nfor\tO\nglaucoma\tB-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nTopical\tO\nbeta\tO\n-\tO\nblocker\tO\ntreatment\tO\nis\tO\nroutine\tO\ntherapy\tO\nin\tO\nthe\tO\nmanagement\tO\nof\tO\npatients\tO\nwith\tO\nglaucoma\tB-Disease\n.\tO\n\nTherapy\tO\nresults\tO\nin\tO\nsystemic\tO\nabsorption\tO\n,\tO\nhowever\tO\n,\tO\nthe\tO\ndegree\tO\nof\tO\nreduction\tO\nof\tO\nresting\tO\nand\tO\npeak\tO\nheart\tO\nrate\tO\nhas\tO\nnot\tO\nbeen\tO\nquantified\tO\n.\tO\n\nDESIGN\tO\n:\tO\nThis\tO\ntrial\tO\nevaluated\tO\nthe\tO\neffect\tO\nof\tO\nplacebo\tO\n,\tO\n0\tO\n.\tO\n5\tO\n%\tO\naqueous\tO\ntimolol\tB-Chemical\n(\tO\ntimolol\tB-Chemical\nsolution\tO\n)\tO\nand\tO\na\tO\n0\tO\n.\tO\n5\tO\n%\tO\ntimolol\tB-Chemical\nsuspension\tO\nthat\tO\nforms\tO\na\tO\ngel\tO\non\tO\napplication\tO\nto\tO\nthe\tO\nconjunctiva\tO\n(\tO\ntimolol\tB-Chemical\ngellan\tO\n)\tO\non\tO\nthe\tO\n24\tO\n-\tO\nhour\tO\nheart\tO\nrate\tO\nin\tO\npatients\tO\ncurrently\tO\nbeing\tO\ntreated\tO\nfor\tO\nglaucoma\tB-Disease\nto\tO\nquantify\tO\nthe\tO\nreduction\tO\nin\tO\nmean\tO\nheart\tO\nrate\tO\n.\tO\n\nMETHODS\tO\n:\tO\nForty\tO\n-\tO\nthree\tO\nCaucasian\tO\npatients\tO\nwith\tO\nprimary\tO\nopen\tB-Disease\n-\tI-Disease\nangle\tI-Disease\nglaucoma\tI-Disease\nor\tO\nocular\tB-Disease\nhypertension\tI-Disease\nwith\tO\na\tO\nmean\tO\n(\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nage\tO\nof\tO\n63\tO\n(\tO\n+\tO\n/\tO\n-\tO\n8\tO\n)\tO\nyears\tO\nwere\tO\nrandomized\tO\nand\tO\ncrossed\tO\nover\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nmasked\tO\nmanner\tO\nto\tO\n14\tO\ndays\tO\nof\tO\ntreatment\tO\nwith\tO\nplacebo\tO\n(\tO\nmorning\tO\nand\tO\nevening\tO\nin\tO\nboth\tO\neyes\tO\n)\tO\n,\tO\ntimolol\tB-Chemical\nsolution\tO\n(\tO\nmorning\tO\nand\tO\nevening\tO\nin\tO\nboth\tO\neyes\tO\n)\tO\n,\tO\nor\tO\ntimolol\tB-Chemical\ngellan\tO\n(\tO\nmorning\tO\nin\tO\nboth\tO\neyes\tO\nwith\tO\nplacebo\tO\nin\tO\nthe\tO\nevening\tO\n)\tO\n.\tO\n\nOn\tO\nthe\tO\n13th\tO\nday\tO\nof\tO\neach\tO\nperiod\tO\n,\tO\nheart\tO\nrate\tO\nwas\tO\nrecorded\tO\ncontinuously\tO\nduring\tO\na\tO\ntypical\tO\n,\tO\nambulant\tO\n24\tO\n-\tO\nhour\tO\nperiod\tO\n.\tO\n\nRESULTS\tO\n:\tO\nBoth\tO\ntimolol\tB-Chemical\nsolution\tO\nand\tO\ntimolol\tB-Chemical\ngellan\tO\nreduced\tO\nthe\tO\nmean\tO\n24\tO\n-\tO\nhour\tO\nheart\tO\nrate\tO\ncompared\tO\nwith\tO\nplacebo\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n.\tO\n001\tO\n)\tO\n,\tO\nand\tO\nthis\tO\nreduction\tO\nwas\tO\nmost\tO\npronounced\tO\nduring\tO\nthe\tO\ndaytime\tO\n(\tO\n-\tO\n7\tO\n.\tO\n5\tO\n%\tO\nchange\tO\nin\tO\nmean\tO\nheart\tO\nrate\tO\n,\tO\n-\tO\n5\tO\n.\tO\n7\tO\nbeats\tO\n/\tO\nmin\tO\n)\tO\n.\tO\n\nTimolol\tB-Chemical\ngellan\tO\nshowed\tO\na\tO\nnumerically\tO\nbut\tO\nnot\tO\nsignificantly\tO\nsmaller\tO\nreduction\tO\nin\tO\n24\tO\n-\tO\nhour\tO\nheart\tO\nrate\tO\n,\tO\ncompared\tO\nwith\tO\ntimolol\tB-Chemical\nsolution\tO\n.\tO\n\nDuring\tO\nthe\tO\nnight\tO\n,\tO\nthe\tO\nmean\tO\n12\tO\n-\tO\nhour\tO\nheart\tO\nrate\tO\non\tO\nplacebo\tO\nand\tO\ntimolol\tB-Chemical\ngellan\tO\nwere\tO\nboth\tO\nsignificantly\tO\nless\tO\nthan\tO\non\tO\ntimolol\tB-Chemical\nsolution\tO\n;\tO\nthe\tO\ndifference\tO\nbetween\tO\nsolution\tO\nand\tO\ngellan\tO\ntreatments\tO\nwas\tO\nstatistically\tO\nsignificant\tO\n(\tO\nP\tO\n=\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nBoth\tO\ntimolol\tB-Chemical\nsolution\tO\nand\tO\ntimolol\tB-Chemical\ngellan\tO\ndecrease\tO\nthe\tO\nmean\tO\n24\tO\n-\tO\nhour\tO\nheart\tO\nrate\tO\ncompared\tO\nwith\tO\nplacebo\tO\n.\tO\n\nThis\tO\nresponse\tO\nwas\tO\nmost\tO\npronounced\tO\nduring\tO\nthe\tO\nactive\tO\ndaytime\tO\nperiod\tO\n.\tO\n\nThese\tO\ndata\tO\nquantify\tO\nthe\tO\nmodest\tO\nbradycardia\tB-Disease\nassociated\tO\nwith\tO\nophthalmic\tO\nbeta\tO\n-\tO\nblocker\tO\ntherapy\tO\nin\tO\na\tO\ntypical\tO\npatient\tO\npopulation\tO\non\tO\ntherapy\tO\nfor\tO\nglaucoma\tB-Disease\n.\tO\n\nAlthough\tO\nexercise\tO\nperformance\tO\nwas\tO\nnot\tO\nassessed\tO\nin\tO\nthis\tO\ntrial\tO\n,\tO\nreductions\tO\nof\tO\nthis\tO\nmagnitude\tO\nshould\tO\nnot\tO\nhave\tO\nsubstantial\tO\nclinical\tO\nconsequences\tO\n.\tO\n\nManagement\tO\nstrategies\tO\nfor\tO\nribavirin\tB-Chemical\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nhepatitis\tB-Disease\nC\tI-Disease\n:\tO\nclinical\tO\nand\tO\neconomic\tO\nimplications\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nRecently\tO\npublished\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nincreased\tO\nefficacy\tO\nand\tO\ncost\tO\n-\tO\neffectiveness\tO\nof\tO\ncombination\tO\ntherapy\tO\nwith\tO\ninterferon\tO\nand\tO\nalpha\tO\n-\tO\n2b\tO\n/\tO\nribavirin\tB-Chemical\ncompared\tO\nwith\tO\ninterferon\tB-Chemical\n-\tI-Chemical\nalpha\tI-Chemical\nmonotherapy\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nC\tI-Disease\n(\tO\nCHC\tB-Disease\n)\tO\n.\tO\n\nCombination\tO\ntherapy\tO\nis\tO\nassociated\tO\nwith\tO\na\tO\nclinically\tO\nimportant\tO\nadverse\tO\neffect\tO\n:\tO\nribavirin\tB-Chemical\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n(\tO\nRIHA\tB-Disease\n)\tO\n.\tO\n\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nevaluate\tO\nthe\tO\ndirect\tO\nhealth\tO\n-\tO\ncare\tO\ncosts\tO\nand\tO\nmanagement\tO\nof\tO\nRIHA\tB-Disease\nduring\tO\ntreatment\tO\nof\tO\nCHC\tB-Disease\nin\tO\na\tO\nclinical\tO\ntrial\tO\nsetting\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nsystematic\tO\nliterature\tO\nreview\tO\nwas\tO\nconducted\tO\nto\tO\nsynthesize\tO\ninformation\tO\non\tO\nthe\tO\nincidence\tO\nand\tO\nmanagement\tO\nof\tO\nRIHA\tB-Disease\n.\tO\n\nDecision\tO\n-\tO\nanalytic\tO\ntechniques\tO\nwere\tO\nused\tO\nto\tO\nestimate\tO\nthe\tO\ncost\tO\nof\tO\ntreating\tO\nRIHA\tB-Disease\n.\tO\n\nUncertainty\tO\nwas\tO\nevaluated\tO\nusing\tO\nsensitivity\tO\nanalyses\tO\n.\tO\n\nRESULTS\tO\n:\tO\nRIHA\tB-Disease\n,\tO\ndefined\tO\nas\tO\na\tO\nreduction\tO\nin\tO\nhemoglobin\tO\nto\tO\nless\tO\nthan\tO\n100\tO\ng\tO\n/\tO\nL\tO\n,\tO\noccurs\tO\nin\tO\napproximately\tO\n7\tO\n%\tO\nto\tO\n9\tO\n%\tO\nof\tO\npatients\tO\ntreated\tO\nwith\tO\ncombination\tO\ntherapy\tO\n.\tO\n\nThe\tO\nstandard\tO\nof\tO\ncare\tO\nfor\tO\nmanagement\tO\nof\tO\nRIHA\tB-Disease\nis\tO\nreduction\tO\nor\tO\ndiscontinuation\tO\nof\tO\nthe\tO\nribavirin\tB-Chemical\ndosage\tO\n.\tO\n\nWe\tO\nestimated\tO\nthe\tO\ndirect\tO\ncost\tO\nof\tO\ntreating\tO\nclinically\tO\nsignificant\tO\nRIHA\tB-Disease\nto\tO\nbe\tO\n170\tO\nper\tO\npatient\tO\nreceiving\tO\ncombination\tO\ntherapy\tO\nper\tO\n48\tO\n-\tO\nweek\tO\ntreatment\tO\ncourse\tO\n(\tO\nrange\tO\n68\tO\n-\tO\n692\tO\n)\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthe\tO\none\tO\n-\tO\nway\tO\nsensitivity\tO\nanalyses\tO\nranged\tO\nfrom\tO\n57\tO\nto\tO\n317\tO\n.\tO\n\nIn\tO\ncomparison\tO\n,\tO\nthe\tO\ncost\tO\nof\tO\n48\tO\nweeks\tO\nof\tO\ncombination\tO\ntherapy\tO\nis\tO\n16\tO\n,\tO\n459\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ndirect\tO\ncost\tO\nof\tO\ntreating\tO\nclinically\tO\nsignificant\tO\nRIHA\tB-Disease\nis\tO\n1\tO\n%\tO\n(\tO\n170\tO\n/\tO\n16\tO\n,\tO\n459\tO\n)\tO\nof\tO\ndrug\tO\ntreatment\tO\ncosts\tO\n.\tO\n\nQuestions\tO\nremain\tO\nabout\tO\nthe\tO\noptimal\tO\ndose\tO\nof\tO\nribavirin\tB-Chemical\nand\tO\nthe\tO\nincidence\tO\nof\tO\nRIHA\tB-Disease\nin\tO\na\tO\nreal\tO\n-\tO\nworld\tO\npopulation\tO\n.\tO\n\nDespite\tO\nthese\tO\nuncertainties\tO\n,\tO\nthis\tO\ninitial\tO\nevaluation\tO\nof\tO\nthe\tO\ndirect\tO\ncost\tO\nof\tO\ntreating\tO\nRIHA\tB-Disease\nprovides\tO\nan\tO\nestimate\tO\nof\tO\nthe\tO\ncost\tO\nand\tO\nmanagement\tO\nimplications\tO\nof\tO\nthis\tO\nclinically\tO\nimportant\tO\nadverse\tO\neffect\tO\n.\tO\n\nPreliminary\tO\nefficacy\tO\nassessment\tO\nof\tO\nintrathecal\tO\ninjection\tO\nof\tO\nan\tO\nAmerican\tO\nformulation\tO\nof\tO\nadenosine\tB-Chemical\nin\tO\nhumans\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nPreclinical\tO\nstudies\tO\nof\tO\nintrathecal\tO\nadenosine\tB-Chemical\nsuggest\tO\nit\tO\nmay\tO\nbe\tO\neffective\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nacute\tB-Disease\nand\tI-Disease\nchronic\tI-Disease\npain\tI-Disease\nin\tO\nhumans\tO\n,\tO\nand\tO\npreliminary\tO\nstudies\tO\nin\tO\nvolunteers\tO\nand\tO\npatients\tO\nwith\tO\na\tO\nSwedish\tO\nformulation\tO\nof\tO\nadenosine\tB-Chemical\nsuggests\tO\nit\tO\nmay\tO\nbe\tO\neffective\tO\nin\tO\nhypersensitivity\tB-Disease\nstates\tO\nbut\tO\nnot\tO\nwith\tO\nacute\tO\nnoxious\tO\nstimulation\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nscreen\tO\nfor\tO\nefficacy\tO\nof\tO\na\tO\ndifferent\tO\nformulation\tO\nof\tO\nadenosine\tB-Chemical\nmarketed\tO\nin\tO\nthe\tO\nUS\tO\n,\tO\nusing\tO\nboth\tO\nacute\tO\nnoxious\tO\nstimulation\tO\nand\tO\ncapsaicin\tB-Chemical\n-\tO\nevoked\tO\nmechanical\tO\nhypersensitivity\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nFollowing\tO\nFood\tO\nand\tO\nDrug\tO\nAdministration\tO\nand\tO\ninstitutional\tO\nreview\tO\nboard\tO\napproval\tO\nand\tO\nwritten\tO\ninformed\tO\nconsent\tO\n,\tO\n65\tO\nvolunteers\tO\nwere\tO\nstudied\tO\nin\tO\ntwo\tO\ntrials\tO\n:\tO\nan\tO\nopen\tO\n-\tO\nlabel\tO\n,\tO\ndose\tO\n-\tO\nescalating\tO\ntrial\tO\nwith\tO\nintrathecal\tO\nadenosine\tB-Chemical\ndoses\tO\nof\tO\n0\tO\n.\tO\n25\tO\n-\tO\n2\tO\n.\tO\n0\tO\nmg\tO\nand\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrial\tO\nof\tO\nadenosine\tB-Chemical\n,\tO\n2\tO\nmg\tO\n.\tO\n\nCerebrospinal\tO\nfluid\tO\nwas\tO\nobtained\tO\nfor\tO\npharmacokinetic\tO\nanalysis\tO\n,\tO\nand\tO\npain\tB-Disease\nratings\tO\nin\tO\nresponse\tO\nto\tO\nacute\tO\nheat\tO\nstimuli\tO\nand\tO\nareas\tO\nof\tO\nmechanical\tB-Disease\nhyperalgesia\tI-Disease\nand\tO\nallodynia\tB-Disease\nafter\tO\nintradermal\tO\ncapsaicin\tB-Chemical\ninjection\tO\nwere\tO\ndetermined\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAdenosine\tB-Chemical\nproduced\tO\nno\tO\neffect\tO\non\tO\npain\tB-Disease\nreport\tO\nto\tO\nacute\tO\nnoxious\tO\nthermal\tO\nor\tO\nchemical\tO\nstimulation\tO\nbut\tO\nreduced\tO\nmechanical\tB-Disease\nhyperalgesia\tI-Disease\nand\tO\nallodynia\tB-Disease\nfrom\tO\nintradermal\tO\ncapsaicin\tB-Chemical\ninjection\tO\nfor\tO\nat\tO\nleast\tO\n24\tO\nh\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nresidence\tO\ntime\tO\nof\tO\nadenosine\tB-Chemical\nin\tO\ncerebrospinal\tO\nfluid\tO\nwas\tO\nshort\tO\n(\tO\n<\tO\n4\tO\nh\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nshow\tO\nselective\tO\ninhibition\tO\nby\tO\nintrathecal\tO\nadenosine\tB-Chemical\nof\tO\nhypersensitivity\tB-Disease\n,\tO\npresumed\tO\nto\tO\nreflect\tO\ncentral\tO\nsensitization\tO\nin\tO\nhumans\tO\nafter\tO\nperipheral\tO\ncapsaicin\tB-Chemical\ninjection\tO\n.\tO\n\nThe\tO\nlong\tO\n-\tO\nlasting\tO\neffect\tO\nis\tO\nconsistent\tO\nwith\tO\nthat\tO\nobserved\tO\nin\tO\npreliminary\tO\nreports\tO\nof\tO\npatients\tO\nwith\tO\nchronic\tO\nneuropathic\tB-Disease\npain\tI-Disease\nand\tO\nis\tO\nnot\tO\ndue\tO\nto\tO\nprolonged\tO\nresidence\tO\nof\tO\nadenosine\tB-Chemical\nin\tO\ncerebrospinal\tO\nfluid\tO\n.\tO\n\nDelayed\tO\n-\tO\nonset\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nHeparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\npresents\tO\n5\tO\nto\tO\n12\tO\ndays\tO\nafter\tO\nheparin\tB-Chemical\nexposure\tO\n,\tO\nwith\tO\nor\tO\nwithout\tO\narterial\tB-Disease\nor\tI-Disease\nvenous\tI-Disease\nthromboemboli\tI-Disease\n.\tO\n\nDelayed\tO\nrecognition\tO\nand\tO\ntreatment\tO\nof\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\ncontribute\tO\nto\tO\npoor\tO\npatient\tO\noutcomes\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\nand\tO\nincrease\tO\nawareness\tO\nof\tO\na\tO\nclinical\tO\nscenario\tO\nin\tO\nwhich\tO\nthe\tO\nonset\tO\nor\tO\nmanifestations\tO\nof\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nare\tO\ndelayed\tO\n.\tO\n\nDESIGN\tO\n:\tO\nRetrospective\tO\ncase\tO\nseries\tO\n.\tO\n\nSETTING\tO\n:\tO\nThree\tO\nlarge\tO\nurban\tO\nhospitals\tO\n(\tO\nwith\tO\nactive\tO\ncardiovascular\tO\nsurgery\tO\nprograms\tO\n)\tO\n.\tO\n\nPATIENTS\tO\n:\tO\n14\tO\npatients\tO\nseen\tO\nover\tO\na\tO\n3\tO\n-\tO\nyear\tO\nperiod\tO\nin\tO\nwhom\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nbecame\tO\napparent\tO\non\tO\ndelayed\tO\npresentation\tO\nwith\tO\nthromboembolic\tB-Disease\ncomplications\tO\n.\tO\n\nMEASUREMENTS\tO\n:\tO\nPlatelet\tO\ncounts\tO\n,\tO\nonset\tO\nof\tO\nobjectively\tO\ndetermined\tO\nthromboembolism\tB-Disease\n,\tO\nresults\tO\nof\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nplatelet\tO\nfactor\tO\n4\tO\nantibody\tO\ntests\tO\n,\tO\nand\tO\noutcomes\tO\n.\tO\n\nRESULTS\tO\n:\tO\nPatients\tO\nwent\tO\nhome\tO\nafter\tO\nhospitalizations\tO\nthat\tO\nhad\tO\nincluded\tO\nheparin\tB-Chemical\nexposure\tO\n-\tO\n-\tO\nin\tO\nmost\tO\ncases\tO\n,\tO\nwith\tO\nno\tO\nthrombocytopenia\tB-Disease\nrecognized\tO\n-\tO\n-\tO\nonly\tO\nto\tO\nreturn\tO\nto\tO\nthe\tO\nhospital\tO\n(\tO\nmedian\tO\n,\tO\nday\tO\n14\tO\n)\tO\nwith\tO\nthromboembolic\tB-Disease\ncomplications\tO\n.\tO\n\nThromboemboli\tB-Disease\nwere\tO\nvenous\tO\n(\tO\n12\tO\npatients\tO\n,\tO\n7\tO\nwith\tO\npulmonary\tB-Disease\nemboli\tI-Disease\n)\tO\nor\tO\narterial\tO\n(\tO\n4\tO\npatients\tO\n)\tO\nor\tO\nboth\tO\n.\tO\n\nPlatelet\tO\ncounts\tO\nwere\tO\nmildly\tO\ndecreased\tO\nin\tO\nall\tO\nbut\tO\n2\tO\npatients\tO\non\tO\nsecond\tO\npresentation\tO\n.\tO\n\nOn\tO\nreadmission\tO\n,\tO\n11\tO\npatients\tO\nreceived\tO\ntherapeutic\tO\nheparin\tB-Chemical\n,\tO\nwhich\tO\nworsened\tO\nthe\tO\npatients\tO\n'\tO\nclinical\tO\ncondition\tO\nand\tO\n,\tO\nin\tO\nall\tO\n11\tO\ncases\tO\n,\tO\ndecreased\tO\nthe\tO\nplatelet\tO\ncount\tO\n(\tO\nmean\tO\nat\tO\nreadmission\tO\n,\tO\n143\tO\nx\tO\n10\tO\n(\tO\n9\tO\n)\tO\ncells\tO\n/\tO\nL\tO\n;\tO\nmean\tO\nnadir\tO\nafter\tO\nheparin\tB-Chemical\nre\tO\n-\tO\nexposure\tO\n,\tO\n39\tO\nx\tO\n10\tO\n(\tO\n9\tO\n)\tO\ncells\tO\n/\tO\nL\tO\n)\tO\n.\tO\n\nResults\tO\nof\tO\nserologic\tO\ntests\tO\nfor\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nantibodies\tO\nwere\tO\npositive\tO\nin\tO\nall\tO\npatients\tO\n.\tO\n\nSubsequent\tO\ntreatments\tO\nincluded\tO\nalternative\tO\nanticoagulants\tO\n(\tO\n11\tO\npatients\tO\n)\tO\n,\tO\nthrombolytic\tO\ndrugs\tO\n(\tO\n3\tO\npatients\tO\n)\tO\n,\tO\ninferior\tO\nvena\tO\ncava\tO\nfilters\tO\n(\tO\n3\tO\npatients\tO\n)\tO\nand\tO\n,\tO\neventually\tO\n,\tO\nwarfarin\tB-Chemical\n(\tO\n11\tO\npatients\tO\n)\tO\n.\tO\n\nThree\tO\npatients\tO\ndied\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDelayed\tO\n-\tO\nonset\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nis\tO\nincreasingly\tO\nbeing\tO\nrecognized\tO\n.\tO\n\nTo\tO\navoid\tO\ndisastrous\tO\noutcomes\tO\n,\tO\nphysicians\tO\nmust\tO\nconsider\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nwhenever\tO\na\tO\nrecently\tO\nhospitalized\tO\npatient\tO\nreturns\tO\nwith\tO\nthromboembolism\tB-Disease\n;\tO\ntherapy\tO\nwith\tO\nalternative\tO\nanticoagulants\tO\n,\tO\nnot\tO\nheparin\tB-Chemical\n,\tO\nshould\tO\nbe\tO\ninitiated\tO\n.\tO\n\nTreatment\tO\nof\tO\nrisperidone\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\nwith\tO\na\tO\ndopamine\tB-Chemical\nagonist\tO\nin\tO\nchildren\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nRisperidone\tB-Chemical\n,\tO\na\tO\npotent\tO\nantagonist\tO\nof\tO\nboth\tO\nserotonergic\tO\n(\tO\n5HT2A\tO\n)\tO\nand\tO\ndopaminergic\tO\nD2\tO\nreceptors\tO\nis\tO\nassociated\tO\nwith\tO\nhyperprolactinemia\tB-Disease\nin\tO\nadults\tO\nand\tO\nchildren\tO\n.\tO\n\nChronically\tO\nelevated\tO\nprolactin\tO\nlevels\tO\nin\tO\nchildren\tO\nwith\tO\nprolactinomas\tB-Disease\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\narrested\tO\ngrowth\tO\nand\tO\ndevelopment\tO\nresulting\tO\nin\tO\neither\tO\ndelayed\tB-Disease\npuberty\tI-Disease\nor\tO\nshort\tO\nstature\tO\n.\tO\n\nThese\tO\npossibilities\tO\nstress\tO\nthe\tO\nimportance\tO\nof\tO\ndeveloping\tO\na\tO\nsafe\tO\nand\tO\neffective\tO\napproach\tO\nto\tO\ndrug\tO\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\nin\tO\nyouth\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\nsuccessful\tO\ntreatment\tO\nof\tO\nrisperidone\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\nwith\tO\ncabergoline\tB-Chemical\nin\tO\nyouth\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nundertook\tO\na\tO\nretrospective\tO\ncase\tO\nreview\tO\nof\tO\nfour\tO\nchildren\tO\nwith\tO\nrisperidone\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\ntreated\tO\nwith\tO\ncabergoline\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nFour\tO\nmales\tO\n(\tO\nage\tO\n6\tO\n-\tO\n11\tO\nyears\tO\n)\tO\nwith\tO\nDiagnostic\tO\nand\tO\nStatistical\tO\nManual\tO\nof\tO\nMental\tB-Disease\nDisorders\tI-Disease\n(\tO\nfourth\tO\nedition\tO\n)\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\nor\tO\npsychoses\tB-Disease\n,\tO\nwith\tO\nrisperidone\tB-Chemical\n-\tO\ninduced\tO\nelevations\tO\nin\tO\nserum\tO\nprolactin\tO\nlevels\tO\n(\tO\n57\tO\n.\tO\n5\tO\n-\tO\n129\tO\nng\tO\n/\tO\nmL\tO\n,\tO\nnormal\tO\n5\tO\n-\tO\n15\tO\nng\tO\n/\tO\nmL\tO\n)\tO\n,\tO\nwere\tO\ntreated\tO\nwith\tO\ncabergoline\tB-Chemical\n(\tO\nmean\tO\ndose\tO\n2\tO\n.\tO\n13\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n09\tO\nmg\tO\n/\tO\nweek\tO\n)\tO\n.\tO\n\nWhen\tO\nserum\tO\nprolactin\tO\nlevels\tO\nnormalized\tO\nin\tO\nall\tO\nfour\tO\nsubjects\tO\n(\tO\nmean\tO\n11\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n10\tO\n.\tO\n9\tO\nng\tO\n/\tO\nmL\tO\n)\tO\n,\tO\nthe\tO\ncabergoline\tB-Chemical\ndose\tO\nwas\tO\nreduced\tO\nto\tO\n1\tO\nmg\tO\n/\tO\nweek\tO\nin\tO\nthree\tO\nof\tO\nfour\tO\nsubjects\tO\n.\tO\n\nThe\tO\nmean\tO\nduration\tO\nof\tO\ntherapy\tO\nwith\tO\ncabergoline\tB-Chemical\nwas\tO\n523\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n129\tO\n.\tO\n7\tO\ndays\tO\n,\tO\nand\tO\nthe\tO\nmean\tO\nduration\tO\nof\tO\ntherapy\tO\nwith\tO\nrisperidone\tB-Chemical\nwas\tO\n788\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n162\tO\n.\tO\n5\tO\ndays\tO\n.\tO\n\nCabergoline\tB-Chemical\nwas\tO\nwell\tO\ntolerated\tO\nwithout\tO\nadverse\tO\neffects\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCabergoline\tB-Chemical\nmay\tO\nbe\tO\nuseful\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nrisperidone\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\nin\tO\nyouth\tO\n;\tO\nhowever\tO\n,\tO\nfurther\tO\nresearch\tO\nis\tO\nneeded\tO\n.\tO\n\nAcute\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\nafter\tO\nexposure\tO\nto\tO\nisoflurane\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nacute\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\nfollowing\tO\nexposure\tO\nto\tO\nthe\tO\ninhalational\tO\nanesthetic\tO\nisoflurane\tB-Chemical\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n70\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nhealthy\tO\nwoman\tO\nfrom\tO\nIraq\tO\ndeveloped\tO\nacute\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n3\tO\nweeks\tO\nfollowing\tO\nrepair\tO\nof\tO\nthe\tO\nright\tO\nrotator\tO\ncuff\tO\nunder\tO\ngeneral\tO\nanesthesia\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nevidence\tO\nfor\tO\nviral\tO\n,\tO\nautoimmune\tO\n,\tO\nor\tO\nmetabolic\tO\ncauses\tO\nof\tO\nhepatitis\tB-Disease\n.\tO\n\nNo\tO\nother\tO\nmedications\tO\nwere\tO\ninvolved\tO\nexcept\tO\nfor\tO\ndipyrone\tB-Chemical\nfor\tO\nanalgesia\tB-Disease\n.\tO\n\nThe\tO\nalanine\tB-Chemical\naminotransferase\tO\nwas\tO\nelevated\tO\nto\tO\na\tO\npeak\tO\nconcentration\tO\nof\tO\n1533\tO\nU\tO\n/\tO\nL\tO\nand\tO\nthe\tO\nserum\tO\nbilirubin\tB-Chemical\nreached\tO\na\tO\npeak\tO\nof\tO\n17\tO\n.\tO\n0\tO\nmg\tO\n/\tO\ndL\tO\n.\tO\n\nThere\tO\nwas\tO\nslow\tO\nimprovement\tO\nover\tO\n4\tO\nmonths\tO\n.\tO\n\nAccidental\tO\nreexposure\tO\nby\tO\nthe\tO\npatient\tO\nto\tO\ndipyrone\tB-Chemical\nwas\tO\nuneventful\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nThe\tO\nclinical\tO\nand\tO\nhistologic\tO\npicture\tO\nof\tO\nthis\tO\ncase\tO\nresembles\tO\nhalothane\tB-Disease\nhepatitis\tI-Disease\n,\tO\nwhich\tO\nhas\tO\na\tO\nsignificant\tO\nmortality\tO\nrate\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIsoflurane\tB-Chemical\n,\tO\na\tO\ncommon\tO\nanesthetic\tO\nagent\tO\n,\tO\ncan\tO\ncause\tO\nsevere\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n.\tO\n\nTorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\ninduced\tO\nby\tO\nmetoclopramide\tB-Chemical\nin\tO\nan\tO\nelderly\tO\nwoman\tO\nwith\tO\npreexisting\tO\ncomplete\tO\nleft\tB-Disease\nbundle\tI-Disease\nbranch\tI-Disease\nblock\tI-Disease\n.\tO\n\nThere\tO\nis\tO\na\tO\ngrowing\tO\nlist\tO\nof\tO\ndrugs\tO\nimplicated\tO\nin\tO\nacquired\tO\nlong\tB-Disease\nQT\tI-Disease\nsyndrome\tI-Disease\nand\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\ntorsadogenic\tO\npotential\tO\nof\tO\nmetoclopramide\tB-Chemical\n,\tO\na\tO\ncommonly\tO\nused\tO\nantiemetic\tO\nand\tO\nprokinetic\tO\ndrug\tO\n,\tO\nhas\tO\nnot\tO\nbeen\tO\nreported\tO\nin\tO\nthe\tO\nliterature\tO\n,\tO\ndespite\tO\nits\tO\nchemical\tO\nsimilarity\tO\nto\tO\nprocainamide\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\non\tO\na\tO\n92\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\npreexisting\tO\ncomplete\tO\nleft\tB-Disease\nbundle\tI-Disease\nbranch\tI-Disease\nblock\tI-Disease\nwho\tO\ndeveloped\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nafter\tO\nintravenous\tO\nand\tO\noral\tO\nadministration\tO\nof\tO\nmetoclopramide\tB-Chemical\n.\tO\n\nThis\tO\npatient\tO\nalso\tO\ndeveloped\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nwhen\tO\ncisapride\tB-Chemical\nand\tO\nerythromycin\tB-Chemical\nwere\tO\ngiven\tO\nsimultaneously\tO\n.\tO\n\nThese\tO\ntwo\tO\nepisodes\tO\nwere\tO\nsuppressed\tO\nsuccessfully\tO\nafter\tO\ndiscontinuing\tO\nthe\tO\noffending\tO\ndrugs\tO\nand\tO\nadministering\tO\nclass\tO\nIB\tO\ndrugs\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\ndocumentation\tO\nthat\tO\nmetoclopramide\tB-Chemical\nprovokes\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nclinically\tO\n.\tO\n\nMetoclopramide\tB-Chemical\nshould\tO\nbe\tO\nused\tO\ncautiously\tO\nin\tO\npatients\tO\nwith\tO\na\tO\nrisk\tO\nof\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n.\tO\n\nDopamine\tB-Chemical\nD2\tO\nreceptor\tO\nsignaling\tO\ncontrols\tO\nneuronal\tO\ncell\tO\ndeath\tO\ninduced\tO\nby\tO\nmuscarinic\tO\nand\tO\nglutamatergic\tO\ndrugs\tO\n.\tO\n\nDopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\n,\tO\nthrough\tO\nD1\tO\n/\tO\nD2\tO\nreceptor\tO\n-\tO\nmediated\tO\nsignaling\tO\n,\tO\nplays\tO\na\tO\nmajor\tO\nrole\tO\nin\tO\nthe\tO\ncontrol\tO\nof\tO\nepileptic\tB-Disease\nseizures\tI-Disease\narising\tO\nin\tO\nthe\tO\nlimbic\tO\nsystem\tO\n.\tO\n\nExcitotoxicity\tB-Disease\nleading\tO\nto\tO\nneuronal\tO\ncell\tO\ndeath\tO\nin\tO\nthe\tO\naffected\tO\nareas\tO\nis\tO\na\tO\nmajor\tO\nconsequence\tO\nof\tO\nseizures\tB-Disease\nat\tO\nthe\tO\ncellular\tO\nlevel\tO\n.\tO\n\nIn\tO\nthis\tO\nrespect\tO\n,\tO\nlittle\tO\nis\tO\nknown\tO\nabout\tO\nthe\tO\nrole\tO\nof\tO\nDA\tB-Chemical\nreceptors\tO\nin\tO\nthe\tO\noccurrence\tO\nof\tO\nepilepsy\tB-Disease\n-\tO\ninduced\tO\nneuronal\tO\ncell\tO\ndeath\tO\n.\tO\n\nHere\tO\nwe\tO\nanalyze\tO\nthe\tO\noccurrence\tO\nof\tO\nseizures\tB-Disease\nand\tO\nneurotoxicity\tB-Disease\nin\tO\nD2R\tO\n-\tO\n/\tO\n-\tO\nmice\tO\ntreated\tO\nwith\tO\nthe\tO\ncholinergic\tO\nagonist\tO\npilocarpine\tB-Chemical\n.\tO\n\nWe\tO\ncompared\tO\nthese\tO\nresults\tO\nwith\tO\nthose\tO\npreviously\tO\nobtained\tO\nwith\tO\nkainic\tB-Chemical\nacid\tI-Chemical\n(\tO\nKA\tB-Chemical\n)\tO\n,\tO\na\tO\npotent\tO\nglutamate\tB-Chemical\nagonist\tO\n.\tO\n\nImportantly\tO\n,\tO\nD2R\tO\n-\tO\n/\tO\n-\tO\nmice\tO\ndevelop\tO\nseizures\tB-Disease\nat\tO\ndoses\tO\nof\tO\nboth\tO\ndrugs\tO\nthat\tO\nare\tO\nnot\tO\nepileptogenic\tO\nfor\tO\nWT\tO\nlittermates\tO\nand\tO\nshow\tO\ngreater\tO\nneurotoxicity\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nresult\tO\nin\tO\na\tO\nmore\tO\nwidespread\tO\nneuronal\tO\ndeath\tO\nin\tO\nboth\tO\nWT\tO\nand\tO\nD2R\tO\n-\tO\n/\tO\n-\tO\nbrains\tO\nin\tO\ncomparison\tO\nto\tO\nKA\tB-Chemical\n.\tO\n\nThus\tO\n,\tO\nthe\tO\nabsence\tO\nof\tO\nD2R\tO\nlowers\tO\nthe\tO\nthreshold\tO\nfor\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\nboth\tO\nglutamate\tB-Chemical\nand\tO\nacetylcholine\tB-Chemical\n.\tO\n\nMoreover\tO\n,\tO\nthe\tO\ndopaminergic\tO\ncontrol\tO\nof\tO\nepilepsy\tB-Disease\n-\tO\ninduced\tO\nneurodegeneration\tB-Disease\nseems\tO\nto\tO\nbe\tO\nmediated\tO\nby\tO\ndistinct\tO\ninteractions\tO\nof\tO\nD2R\tO\nsignaling\tO\nwith\tO\nthese\tO\ntwo\tO\nneurotransmitters\tO\n.\tO\n\nSteroid\tB-Chemical\nstructure\tO\nand\tO\npharmacological\tO\nproperties\tO\ndetermine\tO\nthe\tO\nanti\tO\n-\tO\namnesic\tB-Disease\neffects\tO\nof\tO\npregnenolone\tB-Chemical\nsulphate\tI-Chemical\nin\tO\nthe\tO\npassive\tO\navoidance\tO\ntask\tO\nin\tO\nrats\tO\n.\tO\n\nPregnenolone\tB-Chemical\nsulphate\tI-Chemical\n(\tO\nPREGS\tB-Chemical\n)\tO\nhas\tO\ngenerated\tO\ninterest\tO\nas\tO\none\tO\nof\tO\nthe\tO\nmost\tO\npotent\tO\nmemory\tO\n-\tO\nenhancing\tO\nneurosteroids\tO\nto\tO\nbe\tO\nexamined\tO\nin\tO\nrodent\tO\nlearning\tO\nstudies\tO\n,\tO\nwith\tO\nparticular\tO\nimportance\tO\nin\tO\nthe\tO\nageing\tO\nprocess\tO\n.\tO\n\nThe\tO\nmechanism\tO\nby\tO\nwhich\tO\nthis\tO\nendogenous\tO\nsteroid\tB-Chemical\nenhances\tO\nmemory\tO\nformation\tO\nis\tO\nhypothesized\tO\nto\tO\ninvolve\tO\nactions\tO\non\tO\nglutamatergic\tO\nand\tO\nGABAergic\tO\nsystems\tO\n.\tO\n\nThis\tO\nhypothesis\tO\nstems\tO\nfrom\tO\nfindings\tO\nthat\tO\nPREGS\tB-Chemical\nis\tO\na\tO\npotent\tO\npositive\tO\nmodulator\tO\nof\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nd\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\nreceptors\tO\n(\tO\nNMDARs\tO\n)\tO\nand\tO\na\tO\nnegative\tO\nmodulator\tO\nof\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n(\tO\nA\tO\n)\tO\nreceptors\tO\n(\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nRs\tO\n)\tO\n.\tO\n\nMoreover\tO\n,\tO\nPREGS\tB-Chemical\nis\tO\nable\tO\nto\tO\nreverse\tO\nthe\tO\namnesic\tB-Disease\n-\tO\nlike\tO\neffects\tO\nof\tO\nNMDAR\tO\nand\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nR\tO\nligands\tO\n.\tO\n\nTo\tO\ninvestigate\tO\nthis\tO\nhypothesis\tO\n,\tO\nthe\tO\npresent\tO\nstudy\tO\nin\tO\nrats\tO\nexamined\tO\nthe\tO\nmemory\tO\n-\tO\naltering\tO\nabilities\tO\nof\tO\nstructural\tO\nanalogs\tO\nof\tO\nPREGS\tB-Chemical\n,\tO\nwhich\tO\ndiffer\tO\nin\tO\ntheir\tO\nmodulation\tO\nof\tO\nNMDAR\tO\nand\tO\n/\tO\nor\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nR\tO\nfunction\tO\n.\tO\n\nThe\tO\nanalogs\tO\ntested\tO\nwere\tO\n:\tO\n11\tB-Chemical\n-\tI-Chemical\nketopregnenolone\tI-Chemical\nsulphate\tI-Chemical\n(\tO\nan\tO\nagent\tO\nthat\tO\nis\tO\ninactive\tO\nat\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nRs\tO\nand\tO\nNMDARs\tO\n)\tO\n,\tO\nepipregnanolone\tB-Chemical\n(\tI-Chemical\n[\tI-Chemical\n3beta\tI-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n5beta\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n]\tI-Chemical\nsulphate\tI-Chemical\n,\tO\nan\tO\ninhibitor\tO\nof\tO\nboth\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nRs\tO\nand\tO\nNMDARs\tO\n)\tO\n,\tO\nand\tO\na\tO\nnewly\tO\nsynthesized\tO\n(\tO\n-\tO\n)\tO\nPREGS\tB-Chemical\nenantiomer\tO\n(\tO\nwhich\tO\nis\tO\nidentical\tO\nto\tO\nPREGS\tB-Chemical\nin\tO\neffects\tO\non\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nRs\tO\nand\tO\nNMDARs\tO\n)\tO\n.\tO\n\nThe\tO\nmemory\tO\n-\tO\nenhancing\tO\neffects\tO\nof\tO\nPREGS\tB-Chemical\nand\tO\nits\tO\nanalogs\tO\nwere\tO\ntested\tO\nin\tO\nthe\tO\npassive\tO\navoidance\tO\ntask\tO\nusing\tO\nthe\tO\nmodel\tO\nof\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\n.\tO\n\nBoth\tO\nPREGS\tB-Chemical\nand\tO\nits\tO\n(\tO\n-\tO\n)\tO\nenantiomer\tO\nblocked\tO\nthe\tO\neffects\tO\nof\tO\nscopolamine\tB-Chemical\n.\tO\n\nThe\tO\nresults\tO\nshow\tO\nthat\tO\n,\tO\nunlike\tO\nPREGS\tB-Chemical\n,\tO\n11\tB-Chemical\n-\tI-Chemical\nketopregnenolone\tI-Chemical\nsulphate\tI-Chemical\nand\tO\nepipregnanolone\tB-Chemical\nsulphate\tI-Chemical\nfailed\tO\nto\tO\nblock\tO\nthe\tO\neffect\tO\nof\tO\nscopolamine\tB-Chemical\n,\tO\nsuggesting\tO\nthat\tO\naltering\tO\nthe\tO\nmodulation\tO\nof\tO\nNMDA\tB-Chemical\nreceptors\tO\ndiminishes\tO\nthe\tO\nmemory\tO\n-\tO\nenhancing\tO\neffects\tO\nof\tO\nPREGS\tB-Chemical\n.\tO\n\nMoreover\tO\n,\tO\nenantioselectivity\tO\nwas\tO\ndemonstrated\tO\nby\tO\nthe\tO\nability\tO\nof\tO\nnatural\tO\nPREGS\tB-Chemical\nto\tO\nbe\tO\nan\tO\norder\tO\nof\tO\nmagnitude\tO\nmore\tO\neffective\tO\nthan\tO\nits\tO\nsynthetic\tO\nenantiomer\tO\nin\tO\nreversing\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\n.\tO\n\nThese\tO\nresults\tO\nidentify\tO\na\tO\nnovel\tO\nneuropharmacological\tO\nsite\tO\nfor\tO\nthe\tO\nmodulation\tO\nof\tO\nmemory\tO\nprocesses\tO\nby\tO\nneuroactive\tO\nsteroids\tB-Chemical\n.\tO\n\nActivation\tO\nof\tO\npoly\tB-Chemical\n(\tI-Chemical\nADP\tI-Chemical\n-\tI-Chemical\nribose\tI-Chemical\n)\tI-Chemical\npolymerase\tO\ncontributes\tO\nto\tO\ndevelopment\tO\nof\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nActivation\tO\nof\tO\nthe\tO\nnuclear\tO\nenzyme\tO\npoly\tB-Chemical\n(\tI-Chemical\nADP\tI-Chemical\n-\tI-Chemical\nribose\tI-Chemical\n)\tI-Chemical\npolymerase\tO\n(\tO\nPARP\tO\n)\tO\nby\tO\noxidant\tO\n-\tO\nmediated\tO\nDNA\tO\ndamage\tO\nis\tO\nan\tO\nimportant\tO\npathway\tO\nof\tO\ncell\tO\ndysfunction\tO\nand\tO\ntissue\tO\ninjury\tO\nin\tO\nconditions\tO\nassociated\tO\nwith\tO\noxidative\tO\nstress\tO\n.\tO\n\nIncreased\tO\noxidative\tO\nstress\tO\nis\tO\na\tO\nmajor\tO\nfactor\tO\nimplicated\tO\nin\tO\nthe\tO\ncardiotoxicity\tB-Disease\nof\tO\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\n,\tO\na\tO\nwidely\tO\nused\tO\nantitumor\tO\nanthracycline\tB-Chemical\nantibiotic\tO\n.\tO\n\nThus\tO\n,\tO\nwe\tO\nhypothesized\tO\nthat\tO\nthe\tO\nactivation\tO\nof\tO\nPARP\tO\nmay\tO\ncontribute\tO\nto\tO\nthe\tO\nDOX\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nUsing\tO\na\tO\ndual\tO\napproach\tO\nof\tO\nPARP\tO\n-\tO\n1\tO\nsuppression\tO\n,\tO\nby\tO\ngenetic\tO\ndeletion\tO\nor\tO\npharmacological\tO\ninhibition\tO\nwith\tO\nthe\tO\nphenanthridinone\tO\nPARP\tO\ninhibitor\tO\nPJ34\tB-Chemical\n,\tO\nwe\tO\nnow\tO\ndemonstrate\tO\nthe\tO\nrole\tO\nof\tO\nPARP\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\ninduced\tO\nby\tO\nDOX\tB-Chemical\n.\tO\n\nPARP\tO\n-\tO\n1\tO\n+\tO\n/\tO\n+\tO\nand\tO\nPARP\tO\n-\tO\n1\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nreceived\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\nDOX\tB-Chemical\n(\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n)\tO\n.\tO\n\nFive\tO\ndays\tO\nafter\tO\nDOX\tB-Chemical\nadministration\tO\n,\tO\nleft\tO\nventricular\tO\nperformance\tO\nwas\tO\nsignificantly\tO\ndepressed\tO\nin\tO\nPARP\tO\n-\tO\n1\tO\n+\tO\n/\tO\n+\tO\nmice\tO\n,\tO\nbut\tO\nonly\tO\nto\tO\na\tO\nsmaller\tO\nextent\tO\nin\tO\nPARP\tO\n-\tO\n1\tO\n-\tO\n/\tO\n-\tO\nones\tO\n.\tO\n\nSimilar\tO\nexperiments\tO\nwere\tO\nconducted\tO\nin\tO\nBALB\tO\n/\tO\nc\tO\nmice\tO\ntreated\tO\nwith\tO\nPJ34\tB-Chemical\nor\tO\nvehicle\tO\n.\tO\n\nTreatment\tO\nwith\tO\na\tO\nPJ34\tB-Chemical\nsignificantly\tO\nimproved\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\nand\tO\nincreased\tO\nthe\tO\nsurvival\tO\nof\tO\nthe\tO\nanimals\tO\n.\tO\n\nIn\tO\naddition\tO\nPJ34\tB-Chemical\nsignificantly\tO\nreduced\tO\nthe\tO\nDOX\tB-Chemical\n-\tO\ninduced\tO\nincrease\tO\nin\tO\nthe\tO\nserum\tO\nlactate\tB-Chemical\ndehydrogenase\tO\nand\tO\ncreatine\tB-Chemical\nkinase\tO\nactivities\tO\nbut\tO\nnot\tO\nmetalloproteinase\tO\nactivation\tO\nin\tO\nthe\tO\nheart\tO\n.\tO\n\nThus\tO\n,\tO\nPARP\tO\nactivation\tO\ncontributes\tO\nto\tO\nthe\tO\ncardiotoxicity\tB-Disease\nof\tO\nDOX\tB-Chemical\n.\tO\n\nPARP\tO\ninhibitors\tO\nmay\tO\nexert\tO\nprotective\tO\neffects\tO\nagainst\tO\nthe\tO\ndevelopment\tO\nof\tO\nsevere\tO\ncardiac\tB-Disease\ncomplications\tI-Disease\nassociated\tO\nwith\tO\nthe\tO\nDOX\tB-Chemical\ntreatment\tO\n.\tO\n\nSpironolactone\tB-Chemical\n:\tO\nis\tO\nit\tO\na\tO\nnovel\tO\ndrug\tO\nfor\tO\nthe\tO\nprevention\tO\nof\tO\namphotericin\tB-Chemical\nB\tI-Chemical\n-\tO\nrelated\tO\nhypokalemia\tB-Disease\nin\tO\ncancer\tB-Disease\npatients\tO\n?\tO\n\nOBJECTIVE\tO\n:\tO\nNephrotoxicity\tB-Disease\nis\tO\nthe\tO\nmajor\tO\nadverse\tO\neffect\tO\nof\tO\namphotericin\tB-Chemical\nB\tI-Chemical\n(\tO\nAmB\tB-Chemical\n)\tO\n,\tO\noften\tO\nlimiting\tO\nadministration\tO\nof\tO\nfull\tO\ndosage\tO\n.\tO\n\nSelective\tO\ndistal\tO\ntubular\tO\nepithelial\tO\ntoxicity\tB-Disease\nseems\tO\nto\tO\nbe\tO\nresponsible\tO\nfor\tO\nthe\tO\nprofound\tO\npotassium\tB-Chemical\nwasting\tO\nthat\tO\nis\tO\na\tO\nmajor\tO\nclinical\tO\nside\tO\neffect\tO\nof\tO\ntreatment\tO\nwith\tO\nAmB\tB-Chemical\n.\tO\n\nPotassium\tB-Chemical\ndepletion\tO\nalso\tO\npotentiates\tO\nthe\tO\ntubular\tO\ntoxicity\tB-Disease\nof\tO\nAmB\tB-Chemical\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nassess\tO\nthe\tO\nability\tO\nof\tO\nspironolactone\tB-Chemical\nto\tO\nreduce\tO\npotassium\tB-Chemical\nrequirements\tO\nand\tO\nto\tO\nprevent\tO\nhypokalemia\tB-Disease\nin\tO\nneutropenic\tB-Disease\npatients\tO\non\tO\nAmB\tB-Chemical\ntreatment\tO\n.\tO\n\nMETHODS\tO\n:\tO\nIn\tO\nthis\tO\nstudy\tO\n26\tO\npatients\tO\nwith\tO\nvarious\tO\nhematological\tB-Disease\ndisorders\tI-Disease\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\neither\tO\nintravenous\tO\nAmB\tB-Chemical\nalone\tO\nor\tO\nAmB\tB-Chemical\nand\tO\noral\tO\nspironolactone\tB-Chemical\n100\tO\nmg\tO\ntwice\tO\ndaily\tO\nwhen\tO\ndeveloping\tO\na\tO\nproven\tO\nor\tO\nsuspected\tO\nfungal\tB-Disease\ninfection\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nPatients\tO\nreceiving\tO\nconcomitant\tO\nAmB\tB-Chemical\nand\tO\nspironolactone\tB-Chemical\nhad\tO\nsignificantly\tO\nhigher\tO\nplasma\tO\npotassium\tB-Chemical\nlevels\tO\nthan\tO\nthose\tO\nreceiving\tO\nAmB\tB-Chemical\nalone\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n0027\tO\n)\tO\n.\tO\n\nThose\tO\npatients\tO\nreceiving\tO\nAmB\tB-Chemical\nand\tO\nspironolactone\tB-Chemical\nrequired\tO\nsignificantly\tO\nless\tO\npotassium\tB-Chemical\nsupplementation\tO\nto\tO\nmaintain\tO\ntheir\tO\nplasma\tO\npotassium\tB-Chemical\nwithin\tO\nthe\tO\nnormal\tO\nrange\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n022\tO\n)\tO\n.\tO\n\nMoreover\tO\n,\tO\nurinary\tO\npotassium\tB-Chemical\nlosses\tO\nwere\tO\nsignificantly\tO\nless\tO\nin\tO\npatients\tO\nreceiving\tO\nAmB\tB-Chemical\nand\tO\nspironolactone\tB-Chemical\nthan\tO\nthose\tO\nreceiving\tO\nAmB\tB-Chemical\nalone\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n040\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nstudy\tO\nshowed\tO\nthat\tO\nspironolactone\tB-Chemical\ncan\tO\nreduce\tO\npotassium\tB-Chemical\nrequirements\tO\nand\tO\nprevent\tO\nhypokalemia\tB-Disease\nby\tO\nreducing\tO\nurinary\tO\npotassium\tB-Chemical\nloss\tO\nin\tO\nneutropenic\tB-Disease\npatients\tO\non\tO\nAmB\tB-Chemical\ntreatment\tO\n.\tO\n\nErectile\tB-Disease\ndysfunction\tI-Disease\noccurs\tO\nfollowing\tO\nsubstantia\tO\nnigra\tO\nlesions\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nErectile\tO\nfunction\tO\nwas\tO\nassessed\tO\n6\tO\nweeks\tO\nfollowing\tO\nuni\tO\n-\tO\nand\tO\nbilateral\tO\ninjections\tO\nof\tO\n6\tB-Chemical\n-\tI-Chemical\nhydroxydopamine\tI-Chemical\nin\tO\nthe\tO\nsubstantia\tO\nnigra\tO\nnucleus\tO\nof\tO\nthe\tO\nbrain\tO\n.\tO\n\nBehavioral\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\npenile\tO\nerections\tO\nwere\tO\nreduced\tO\n(\tO\n5\tO\n/\tO\n8\tO\n)\tO\nand\tO\nincreased\tO\n(\tO\n3\tO\n/\tO\n8\tO\n)\tO\nin\tO\nuni\tO\n-\tO\nand\tO\nbilateral\tO\nlesioned\tO\nanimals\tO\n.\tO\n\nIntracavernous\tO\npressures\tO\n,\tO\nfollowing\tO\nelectrical\tO\nstimulation\tO\nof\tO\nthe\tO\ncavernous\tO\nnerve\tO\n,\tO\ndecreased\tO\nin\tO\nlesioned\tO\nanimals\tO\n.\tO\n\nLesions\tO\nof\tO\nthe\tO\nsubstantia\tO\nnigra\tO\nwere\tO\nconfirmed\tO\nby\tO\nhistology\tO\n.\tO\n\nConcentration\tO\nof\tO\ndopamine\tB-Chemical\nand\tO\nits\tO\nmetabolites\tO\nwere\tO\ndecreased\tO\nin\tO\nthe\tO\nstriatum\tO\nof\tO\nsubstantia\tO\nnigra\tO\nlesioned\tO\nrats\tO\n.\tO\n\nLesions\tO\nof\tO\nthe\tO\nsubstantia\tO\nnigra\tO\nare\tO\ntherefore\tO\nassociated\tO\nwith\tO\nerectile\tB-Disease\ndysfunction\tI-Disease\nin\tO\nrats\tO\nand\tO\nmay\tO\nserve\tO\nas\tO\na\tO\nmodel\tO\nto\tO\nstudy\tO\nerectile\tB-Disease\ndysfunction\tI-Disease\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nNicotine\tB-Chemical\npotentiation\tO\nof\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\neffects\tO\nof\tO\nnicotine\tB-Chemical\non\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nmorphine\tB-Chemical\nin\tO\nmice\tO\nhave\tO\nbeen\tO\ninvestigated\tO\n.\tO\n\nMorphine\tB-Chemical\nbut\tO\nnot\tO\nnicotine\tB-Chemical\ninduced\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\ncatalepsy\tB-Disease\n.\tO\n\nThe\tO\nresponse\tO\nof\tO\nmorphine\tB-Chemical\nwas\tO\npotentiated\tO\nby\tO\nnicotine\tB-Chemical\n.\tO\n\nIntraperitoneal\tO\nadministration\tO\nof\tO\natropine\tB-Chemical\n,\tO\nnaloxone\tB-Chemical\n,\tO\nmecamylamine\tB-Chemical\n,\tO\nand\tO\nhexamethonium\tB-Chemical\nto\tO\nmice\tO\nreduced\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\na\tO\ncombination\tO\nof\tO\nmorphine\tB-Chemical\nwith\tO\nnicotine\tB-Chemical\n.\tO\n\nIntracerebroventricular\tO\ninjection\tO\nof\tO\natropine\tB-Chemical\n,\tO\nhexamethonium\tB-Chemical\n,\tO\nand\tO\nnaloxone\tB-Chemical\nalso\tO\ndecreased\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nmorphine\tB-Chemical\nplus\tO\nnicotine\tB-Chemical\n.\tO\n\nIntraperitoneal\tO\nadministration\tO\nof\tO\natropine\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nintraperitoneal\tO\nor\tO\nintracerebroventricular\tO\ninjection\tO\nof\tO\nhexamethonium\tB-Chemical\n,\tO\ndecreased\tO\nthe\tO\neffect\tO\nof\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nmorphine\tB-Chemical\n.\tO\n\nIt\tO\nwas\tO\nconcluded\tO\nthat\tO\nmorphine\tB-Chemical\ncatalepsy\tB-Disease\ncan\tO\nbe\tO\nelicited\tO\nby\tO\nopioid\tO\nand\tO\ncholinergic\tO\nreceptors\tO\n,\tO\nand\tO\nthe\tO\npotentiation\tO\nof\tO\nmorphine\tB-Chemical\ninduced\tO\nby\tO\nnicotine\tB-Chemical\nmay\tO\nalso\tO\nbe\tO\nmediated\tO\nthrough\tO\ncholinergic\tO\nreceptor\tO\nmechanisms\tO\n.\tO\n\nForce\tO\noverflow\tO\nand\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nWe\tO\nassessed\tO\nforce\tO\ncoordination\tO\nof\tO\nthe\tO\nhand\tO\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nand\tO\nits\tO\nrelationship\tO\nto\tO\nmotor\tO\ncomplications\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\n,\tO\nparticularly\tO\nto\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n(\tO\nLID\tB-Disease\n)\tO\n.\tO\n\nWe\tO\nstudied\tO\ntwo\tO\ngroups\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\npatients\tO\nwith\tO\n(\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n+\tO\nLID\tB-Disease\n,\tO\nn\tO\n=\tO\n23\tO\n)\tO\nand\tO\nwithout\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n(\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n-\tO\nLID\tB-Disease\n,\tO\nn\tO\n=\tO\n10\tO\n)\tO\n,\tO\nand\tO\nage\tO\n-\tO\nmatched\tO\nhealthy\tO\ncontrols\tO\n.\tO\n\nThe\tO\nmotor\tO\nscore\tO\nof\tO\nthe\tO\nUnified\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nRating\tO\nScale\tO\n,\tO\na\tO\ndyskinesia\tB-Disease\nscore\tO\nand\tO\nforce\tO\nin\tO\na\tO\ngrip\tO\n-\tO\nlift\tO\nparadigm\tO\nwere\tO\nassessed\tO\nON\tO\nand\tO\nOFF\tO\nlevodopa\tB-Chemical\n.\tO\n\nA\tO\npathological\tO\nincrease\tO\nof\tO\nforces\tO\nwas\tO\nseen\tO\nin\tO\nON\tO\n-\tO\nstate\tO\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n+\tO\nLID\tB-Disease\nonly\tO\n.\tO\n\nIn\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n+\tO\nLID\tB-Disease\n,\tO\nthe\tO\nforce\tO\ninvolved\tO\nin\tO\npressing\tO\ndown\tO\nthe\tO\nobject\tO\nbefore\tO\nlifting\tO\nwas\tO\nsignificantly\tO\nincreased\tO\nby\tO\nlevodopa\tB-Chemical\n(\tO\nby\tO\n61\tO\n%\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nAn\tO\novershooting\tO\nof\tO\npeak\tO\ngrip\tO\nforce\tO\nby\tO\n51\tO\n%\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nof\tO\nstatic\tO\ngrip\tO\nforce\tO\nby\tO\n45\tO\n%\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\nON\tO\n-\tO\ncompared\tO\nwith\tO\nthe\tO\nOFF\tO\n-\tO\ndrug\tO\ncondition\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nno\tO\nexcessive\tO\nforce\tO\nwas\tO\nfound\tO\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n-\tO\nLID\tB-Disease\n.\tO\n\nPeak\tO\ngrip\tO\nforce\tO\nin\tO\nON\tO\n-\tO\nstate\tO\nwas\tO\n140\tO\n%\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nhigher\tO\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n+\tO\nLID\tB-Disease\nthan\tO\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n-\tO\nLID\tB-Disease\n,\tO\nwhile\tO\nstatic\tO\ngrip\tO\nforce\tO\nwas\tO\nincreased\tO\nby\tO\n138\tO\n%\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nbetween\tO\ngroups\tO\n.\tO\n\nSeverity\tO\nof\tO\npeak\tO\n-\tO\ndose\tO\ndyskinesias\tB-Disease\nwas\tO\nstrongly\tO\ncorrelated\tO\nwith\tO\ngrip\tO\nforce\tO\nin\tO\nON\tO\n-\tO\nstate\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n79\tO\nwith\tO\npeak\tO\nforce\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nNo\tO\ncorrelation\tO\nwas\tO\nobserved\tO\nbetween\tO\nforces\tO\nand\tO\nthe\tO\nmotor\tO\nscore\tO\nas\tO\nwell\tO\nas\tO\nwith\tO\nthe\tO\ndaily\tO\ndose\tO\nof\tO\ndopaminergic\tO\nmedication\tO\n.\tO\n\nForce\tO\nexcess\tO\nwas\tO\nonly\tO\nobserved\tO\nin\tO\npatients\tO\nwith\tO\nLID\tB-Disease\nand\tO\nmotor\tO\nfluctuations\tO\n.\tO\n\nA\tO\nclose\tO\nrelationship\tO\nwas\tO\nseen\tO\nbetween\tO\nthe\tO\novershooting\tO\nof\tO\nforces\tO\nand\tO\ndyskinesias\tB-Disease\nin\tO\nthe\tO\nON\tO\n-\tO\ndrug\tO\ncondition\tO\n.\tO\n\nWe\tO\npostulate\tO\nthat\tO\nboth\tO\nLID\tB-Disease\nand\tO\ngrip\tO\nforce\tO\nexcess\tO\nshare\tO\ncommon\tO\npathophysiological\tO\nmechanisms\tO\nrelated\tO\nto\tO\nmotor\tO\nfluctuations\tO\n.\tO\n\nBehavioral\tO\neffects\tO\nof\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\non\tO\nreserpine\tB-Chemical\n-\tO\ntreated\tO\nmice\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ndizocilpine\tB-Chemical\n(\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n)\tO\n,\tO\na\tO\nnoncompetitive\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nreceptor\tO\nantagonist\tO\n,\tO\nwere\tO\nstudied\tO\non\tO\ndopamine\tB-Chemical\n-\tO\nrelated\tO\nbehaviors\tO\ninduced\tO\nby\tO\nreserpine\tB-Chemical\ntreatments\tO\n.\tO\n\nThis\tO\nstudy\tO\nfocuses\tO\non\tO\nbehavioral\tO\nsyndromes\tO\nthat\tO\nmay\tO\nused\tO\nas\tO\nmodels\tO\nfor\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n,\tO\nor\tO\ntardive\tB-Disease\ndyskinesia\tI-Disease\n,\tO\nand\tO\nits\tO\nresponse\tO\nafter\tO\nglutamatergic\tO\nblockage\tO\n.\tO\n\nReserpine\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nadministered\tO\nonce\tO\nevery\tO\nother\tO\nday\tO\nfor\tO\n4\tO\ndays\tO\n,\tO\nproduced\tO\nincreases\tO\nin\tO\norofacial\tB-Disease\ndyskinesia\tI-Disease\n,\tO\ntongue\tO\nprotrusion\tO\nand\tO\nvacuous\tO\nchewing\tO\nin\tO\nmice\tO\n,\tO\nwhich\tO\nare\tO\nsigns\tO\nindicative\tO\nof\tO\ntardive\tB-Disease\ndyskinesia\tI-Disease\n.\tO\n\nReserpine\tB-Chemical\nalso\tO\nproduced\tO\ntremor\tB-Disease\nand\tO\ncatalepsy\tB-Disease\n,\tO\nwhich\tO\nare\tO\nsigns\tO\nsuggestive\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nadministered\tO\n30\tO\nmin\tO\nbefore\tO\nthe\tO\nobservation\tO\ntest\tO\n,\tO\nprevented\tO\nthe\tO\nvacuous\tO\nchewing\tO\nmovements\tO\n,\tO\ntongue\tO\nprotrusions\tO\nand\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nreserpine\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\ninjection\tO\nproduced\tO\na\tO\nsignificant\tO\nincrease\tO\nof\tO\ntremor\tB-Disease\nin\tO\nreserpine\tB-Chemical\n-\tO\ntreated\tO\nmice\tO\n.\tO\n\nReserpine\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nadministered\tO\n90\tO\nmin\tO\nbefore\tO\nthe\tO\ntest\tO\nand\tO\nfollowed\tO\nby\tO\napomophine\tB-Chemical\ninjection\tO\n(\tO\n0\tO\n.\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n5\tO\nmin\tO\nbefore\tO\nthe\tO\ntest\tO\n,\tO\ndid\tO\nnot\tO\nproduce\tO\noral\tB-Disease\ndyskinesia\tI-Disease\nin\tO\nmice\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nreserpine\tB-Chemical\ninduced\tO\nincreases\tO\nin\tO\ntremor\tB-Disease\nand\tO\ncatalepsy\tB-Disease\ncompared\tO\nto\tO\ncontrol\tO\nmice\tO\n.\tO\n\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nadministration\tO\nattenuated\tO\nthe\tO\ncatalepsy\tB-Disease\nand\tO\ntremor\tB-Disease\ninduced\tO\nby\tO\nreserpine\tB-Chemical\n.\tO\n\nPretreatment\tO\nwith\tO\nreserpine\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n24\tO\nh\tO\nbefore\tO\nthe\tO\nobservation\tO\ntest\tO\nproduced\tO\nincreases\tO\nin\tO\nvacuous\tO\nchewing\tO\nmovements\tO\nand\tO\ntongue\tO\nprotrusion\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nincreases\tO\nin\tO\ntremor\tB-Disease\nand\tO\ncatalepsy\tB-Disease\n,\tO\nwhereas\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ninjection\tO\n90\tO\nmin\tO\nbefore\tO\nthe\tO\ntest\tO\nreversed\tO\nthe\tO\neffects\tO\nof\tO\nreserpine\tB-Chemical\n.\tO\n\nThese\tO\nresults\tO\nshow\tO\nthat\tO\nreserpine\tB-Chemical\nproduces\tO\ndifferent\tO\nand\tO\nabnormal\tB-Disease\nmovements\tI-Disease\n,\tO\nwhich\tO\nare\tO\nrelated\tO\nto\tO\ndose\tO\nand\tO\nschedule\tO\nemployed\tO\nand\tO\ncan\tO\nbe\tO\nconsidered\tO\nas\tO\nparkinsonian\tB-Disease\n-\tO\nlike\tO\nand\tO\ntardive\tB-Disease\ndsykinesia\tI-Disease\nsigns\tO\n.\tO\n\nThe\tO\nglutamatergic\tO\nblockage\tO\nproduced\tO\nby\tO\nNMDA\tB-Chemical\ncan\tO\nrestore\tO\nthese\tO\nsigns\tO\n,\tO\nsuch\tO\nas\tO\nvacuous\tO\nchewing\tO\nmovements\tO\n,\tO\ntongue\tO\nprotrusions\tO\n,\tO\ncatalepsy\tB-Disease\nand\tO\ntremor\tB-Disease\naccording\tO\nto\tO\nthe\tO\nemployed\tO\nmodel\tO\n.\tO\n\nRisperidone\tB-Chemical\n-\tO\nassociated\tO\n,\tO\nbenign\tO\ntransient\tO\nvisual\tB-Disease\ndisturbances\tI-Disease\nin\tO\nschizophrenic\tB-Disease\npatients\tO\nwith\tO\na\tO\npast\tO\nhistory\tO\nof\tO\nLSD\tB-Chemical\nabuse\tO\n.\tO\n\nTwo\tO\nschizophrenic\tB-Disease\npatients\tO\n,\tO\nwho\tO\nhad\tO\na\tO\nprior\tO\nhistory\tO\nof\tO\nLSD\tB-Chemical\nabuse\tO\nand\tO\nwho\tO\nhad\tO\npreviously\tO\ndeveloped\tO\nEPS\tB-Disease\nwith\tO\nclassic\tO\nantipsychotics\tO\n,\tO\nwere\tO\nsuccessfully\tO\ntreated\tO\nwith\tO\nrisperidone\tB-Chemical\n.\tO\n\nThey\tO\nboth\tO\nreported\tO\nshort\tO\nepisodes\tO\nof\tO\ntransient\tO\nvisual\tB-Disease\ndisturbances\tI-Disease\n,\tO\nwhich\tO\nappeared\tO\nimmediately\tO\nafter\tO\nstarting\tO\ntreatment\tO\nwith\tO\nrisperidone\tB-Chemical\n.\tO\n\nThis\tO\nimagery\tO\nresembled\tO\nvisual\tB-Disease\ndisturbances\tI-Disease\npreviously\tO\nexperienced\tO\nas\tO\n\"\tO\nflashbacks\tO\n\"\tO\nrelated\tO\nto\tO\nprior\tO\nLSD\tB-Chemical\nconsumption\tO\n.\tO\n\nRisperidone\tB-Chemical\nadministration\tO\nwas\tO\ncontinued\tO\nand\tO\nthe\tO\nvisual\tB-Disease\ndisturbances\tI-Disease\ngradually\tO\nwore\tO\noff\tO\n.\tO\n\nDuring\tO\na\tO\nsix\tO\n-\tO\nmonth\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n,\tO\nthere\tO\nwas\tO\nno\tO\nrecurrence\tO\nof\tO\nvisual\tB-Disease\ndisturbances\tI-Disease\n.\tO\n\nThis\tO\nphenomenon\tO\nmay\tO\nbe\tO\ninterpreted\tO\nas\tO\na\tO\nbenign\tO\n,\tO\nshort\tO\n-\tO\nterm\tO\nand\tO\nself\tO\n-\tO\nlimiting\tO\nside\tO\neffect\tO\nwhich\tO\ndoes\tO\nnot\tO\ncontraindicate\tO\nthe\tO\nuse\tO\nof\tO\nrisperidone\tB-Chemical\nor\tO\ninterfere\tO\nwith\tO\ntreatment\tO\n.\tO\n\nConclusions\tO\nbased\tO\non\tO\ntwo\tO\ncase\tO\nreports\tO\nshould\tO\nbe\tO\ntaken\tO\nwith\tO\nappropriate\tO\ncaution\tO\n.\tO\n\nTopiramate\tB-Chemical\n-\tO\ninduced\tO\nnephrolithiasis\tB-Disease\n.\tO\n\nTopiramate\tB-Chemical\nis\tO\na\tO\nrecently\tO\ndeveloped\tO\nantiepileptic\tO\nmedication\tO\nthat\tO\nis\tO\nbecoming\tO\nmore\tO\nwidely\tO\nprescribed\tO\nbecause\tO\nof\tO\nits\tO\nefficacy\tO\nin\tO\ntreating\tO\nrefractory\tB-Disease\nseizures\tI-Disease\n.\tO\n\nUrologists\tO\nshould\tO\nbe\tO\naware\tO\nthat\tO\nthis\tO\nmedication\tO\ncan\tO\ncause\tO\nmetabolic\tB-Disease\nacidosis\tI-Disease\nin\tO\npatients\tO\nsecondary\tO\nto\tO\ninhibition\tO\nof\tO\ncarbonic\tO\nanhydrase\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\na\tO\ndistal\tO\ntubular\tO\nacidification\tO\ndefect\tO\nmay\tO\nresult\tO\n,\tO\nthus\tO\nimpairing\tO\nthe\tO\nnormal\tO\ncompensatory\tO\ndrop\tO\nin\tO\nurine\tO\npH\tO\n.\tO\n\nThese\tO\nfactors\tO\ncan\tO\nlead\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\ncalcium\tB-Chemical\nphosphate\tI-Chemical\nnephrolithiasis\tB-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\nfirst\tO\ntwo\tO\ncases\tO\nof\tO\ntopiramate\tB-Chemical\n-\tO\ninduced\tO\nnephrolithiasis\tB-Disease\nin\tO\nthe\tO\nurologic\tO\nliterature\tO\n.\tO\n\nKetamine\tB-Chemical\nin\tO\nwar\tO\n/\tO\ntropical\tO\nsurgery\tO\n(\tO\na\tO\nfinal\tO\ntribute\tO\nto\tO\nthe\tO\nracemic\tO\nmixture\tO\n)\tO\n.\tO\n\nA\tO\ntechnique\tO\nof\tO\ncontinuous\tO\nintravenous\tO\nanaesthesia\tO\nwith\tO\nketamine\tB-Chemical\nwas\tO\nused\tO\nsuccessfully\tO\nduring\tO\nthe\tO\nSomalia\tO\ncivil\tO\nwar\tO\nin\tO\n1994\tO\nand\tO\nin\tO\nnorth\tO\nUganda\tO\nin\tO\n1999\tO\nfor\tO\n64\tO\noperations\tO\nin\tO\n62\tO\npatients\tO\n,\tO\naged\tO\nfrom\tO\n6\tO\nweeks\tO\nto\tO\n70\tO\nyears\tO\n,\tO\nundergoing\tO\nlimb\tO\nand\tO\nabdominal\tO\nsurgery\tO\nincluding\tO\ncaesarian\tO\nsections\tO\nand\tO\ninterventions\tO\nin\tO\nneonates\tO\n.\tO\n\nOperations\tO\nlasting\tO\nup\tO\nto\tO\n2h\tO\ncould\tO\nbe\tO\nperformed\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nsophisticated\tO\nequipment\tO\nsuch\tO\nas\tO\npulse\tO\noximeters\tO\nor\tO\nventilators\tO\nin\tO\npatients\tO\non\tO\nspontaneous\tO\nventilation\tO\nbreathing\tO\nair\tO\n/\tO\noxygen\tB-Chemical\nonly\tO\n.\tO\n\nAfter\tO\npremedication\tO\nwith\tO\ndiazepam\tB-Chemical\n,\tO\nglycopyrrolate\tB-Chemical\nand\tO\nlocal\tO\nanaesthesia\tO\n,\tO\nand\tO\ninduction\tO\nwith\tO\nstandard\tO\ndoses\tO\nof\tO\nketamine\tB-Chemical\n,\tO\na\tO\nmaintenance\tO\ndose\tO\nof\tO\n10\tO\n-\tO\n20\tO\nmicrog\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\nof\tO\nketamine\tB-Chemical\nproved\tO\nsafe\tO\nand\tO\neffective\tO\n.\tO\n\nEmphasis\tO\nwas\tO\nplaced\tO\non\tO\nbedside\tO\nclinical\tO\nmonitoring\tO\n,\tO\nrelying\tO\nheavily\tO\non\tO\nthe\tO\nheart\tO\nrate\tO\n.\tO\n\nDiazepam\tB-Chemical\n,\tO\nunless\tO\ncontraindicated\tO\nor\tO\nrisky\tO\n,\tO\nremains\tO\nthe\tO\nonly\tO\nnecessary\tO\ncomplementary\tO\ndrug\tO\nto\tO\nketamine\tB-Chemical\nas\tO\nit\tO\nbuffers\tO\nits\tO\ncardiovascular\tO\nresponse\tO\nand\tO\ndecreases\tO\nthe\tO\nduration\tO\nand\tO\nintensity\tO\nof\tO\noperative\tO\nand\tO\npostoperative\tO\nhallucinations\tB-Disease\n.\tO\n\nLocal\tO\nanaesthetic\tO\nblocks\tO\nwere\tO\nuseful\tO\nin\tO\ndecreasing\tO\nthe\tO\nrequirement\tO\nfor\tO\npostoperative\tO\nanalgesia\tB-Disease\n.\tO\n\nAn\tO\nantisialogue\tO\nwas\tO\nusually\tO\nunnecessary\tO\nin\tO\noperations\tO\nlasting\tO\nup\tO\nto\tO\n2\tO\nh\tO\n,\tO\nglycopyrrolate\tB-Chemical\nbeing\tO\nthe\tO\nbest\tO\nchoice\tO\nfor\tO\nits\tO\nlowest\tO\npsychotropic\tO\nand\tO\nchronotropic\tO\neffects\tO\n,\tO\nespecially\tO\nin\tO\na\tO\nhot\tO\nclimate\tO\n.\tO\n\nExperience\tO\nin\tO\nwar\tO\n/\tO\ntropical\tO\nsettings\tO\nsuggests\tO\nthis\tO\ntechnique\tO\ncould\tO\nbe\tO\nuseful\tO\nin\tO\ncivilian\tO\ncontexts\tO\nsuch\tO\nas\tO\noutdoor\tO\nlife\tO\n-\tO\nsaving\tO\nemergency\tO\nsurgery\tO\nor\tO\nin\tO\nmass\tO\ncasualties\tO\nwhere\tO\n,\tO\ne\tO\n.\tO\ng\tO\n.\tO\namputation\tO\nand\tO\nrapid\tO\nextrication\tO\nwere\tO\nrequired\tO\n.\tO\n\nIntravenous\tO\nribavirin\tB-Chemical\ntreatment\tO\nfor\tO\nsevere\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\nin\tO\nimmunocompromised\tO\nchildren\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAdenovirus\tO\nis\tO\nan\tO\nimportant\tO\ncause\tO\nof\tO\nmorbidity\tO\nand\tO\nmortality\tO\nin\tO\nthe\tO\nimmunocompromised\tO\nhost\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nsevere\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\nin\tO\npediatrics\tO\nis\tO\nincreasing\tO\nin\tO\nassociation\tO\nwith\tO\ngrowing\tO\nnumbers\tO\nof\tO\nimmunocompromised\tO\nchildren\tO\n,\tO\nwhere\tO\ncase\tO\nfatality\tO\nrates\tO\nas\tO\nhigh\tO\nas\tO\n50\tO\n%\tO\nto\tO\n80\tO\n%\tO\nhave\tO\nbeen\tO\nreported\tO\n.\tO\n\nThere\tO\nare\tO\nno\tO\napproved\tO\nantiviral\tO\nagents\tO\nwith\tO\nproven\tO\nefficacy\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nsevere\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\n,\tO\nnor\tO\nare\tO\nthere\tO\nany\tO\nprospective\tO\nrandomized\tO\n,\tO\ncontrolled\tO\ntrials\tO\nof\tO\npotentially\tO\nuseful\tO\nanti\tO\n-\tO\nadenovirus\tO\ntherapies\tO\n.\tO\n\nApparent\tO\nclinical\tO\nsuccess\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nsevere\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\nis\tO\nlimited\tO\nto\tO\na\tO\nfew\tO\ncase\tO\nreports\tO\nand\tO\nsmall\tO\nseries\tO\n.\tO\n\nExperience\tO\nis\tO\ngreatest\tO\nwith\tO\nintravenous\tO\nribavirin\tB-Chemical\nand\tO\ncidofovir\tB-Chemical\n.\tO\n\nRibavirin\tB-Chemical\n,\tO\na\tO\nguanosine\tB-Chemical\nanalogue\tO\n,\tO\nhas\tO\nbroad\tO\nantiviral\tO\nactivity\tO\nagainst\tO\nboth\tO\nRNA\tO\nand\tO\nDNA\tO\nviruses\tO\n,\tO\nincluding\tO\ndocumented\tO\nactivity\tO\nagainst\tO\nadenovirus\tO\nin\tO\nvitro\tO\n.\tO\n\nRibavirin\tB-Chemical\nis\tO\nlicensed\tO\nin\tO\naerosol\tO\nform\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nrespiratory\tB-Disease\nsyncytial\tI-Disease\nvirus\tI-Disease\ninfection\tI-Disease\n,\tO\nand\tO\norally\tO\nin\tO\ncombination\tO\nwith\tO\ninterferon\tO\nto\tO\ntreat\tO\nhepatitis\tB-Disease\nC\tI-Disease\n.\tO\n\nIntravenous\tO\nribavirin\tB-Chemical\nis\tO\nthe\tO\ntreatment\tO\nof\tO\nchoice\tO\nfor\tO\ninfection\tB-Disease\nwith\tI-Disease\nhemorrhagic\tI-Disease\nfever\tI-Disease\nviruses\tI-Disease\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tO\neffect\tO\nof\tO\nintravenous\tO\nribavirin\tB-Chemical\nis\tO\nreversible\tO\nmild\tO\nanemia\tB-Disease\n.\tO\n\nThe\tO\nuse\tO\nof\tO\ncidofovir\tB-Chemical\nin\tO\nsevere\tO\nadenovirus\tB-Disease\ninfection\tI-Disease\nhas\tO\nbeen\tO\nlimited\tO\nby\tO\nadverse\tO\neffects\tO\n,\tO\nthe\tO\nmost\tO\nsignificant\tO\nof\tO\nwhich\tO\nis\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nWe\tO\nreport\tO\nour\tO\nexperience\tO\nwith\tO\nintravenous\tO\nribavirin\tB-Chemical\ntherapy\tO\nfor\tO\nsevere\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\nin\tO\na\tO\nseries\tO\nof\tO\nimmunocompromised\tO\nchildren\tO\nand\tO\nreview\tO\nthe\tO\nliterature\tO\n.\tO\n\nDESIGN\tO\n/\tO\nMETHODS\tO\n:\tO\nWe\tO\nretrospectively\tO\nreviewed\tO\nthe\tO\nmedical\tO\nrecords\tO\nof\tO\n5\tO\nchildren\tO\ntreated\tO\nwith\tO\nintravenous\tO\nribavirin\tB-Chemical\nfor\tO\ndocumented\tO\nsevere\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\nadenovirus\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\nafter\tO\ncardiac\tO\nand\tO\nbone\tO\nmarrow\tO\ntransplants\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nbone\tO\nmarrow\tO\ntransplant\tO\npatient\tO\nalso\tO\nreceived\tO\nintravenous\tO\ncidofovir\tB-Chemical\nfor\tO\nprogressive\tO\ndisseminated\tO\ndisease\tO\n.\tO\n\nAn\tO\nadditional\tO\n3\tO\nchildren\tO\ndeveloped\tO\nadenovirus\tB-Disease\npneumonia\tI-Disease\n;\tO\n2\tO\nwere\tO\nneonates\tO\n,\tO\n1\tO\nof\tO\nwhom\tO\nhad\tO\npartial\tO\nDiGeorge\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\nremaining\tO\ninfant\tO\nhad\tO\nrecently\tO\nundergone\tO\na\tO\ncardiac\tO\ntransplant\tO\n.\tO\n\nIntravenous\tO\nribavirin\tB-Chemical\nwas\tO\nadministered\tO\non\tO\na\tO\ncompassionate\tO\n-\tO\nuse\tO\nprotocol\tO\n.\tO\n\nRESULTS\tO\n:\tO\nComplete\tO\nclinical\tO\nrecovery\tO\nfollowed\tO\nlater\tO\nby\tO\nviral\tO\nclearance\tO\nwas\tO\nobserved\tO\nin\tO\n2\tO\nchildren\tO\n:\tO\nthe\tO\ncardiac\tO\ntransplant\tO\nrecipient\tO\nwith\tO\nadenovirus\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\nand\tO\nthe\tO\nimmunocompetent\tO\nneonate\tO\nwith\tO\nadenovirus\tB-Disease\npneumonia\tI-Disease\n.\tO\n\nThe\tO\nremaining\tO\n3\tO\nchildren\tO\ndied\tO\nof\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\n.\tO\n\nIntravenous\tO\nribavirin\tB-Chemical\ntherapy\tO\nwas\tO\nwell\tO\ntolerated\tO\n.\tO\n\nUse\tO\nof\tO\ncidofovir\tB-Chemical\nin\tO\n1\tO\nchild\tO\nwas\tO\nassociated\tO\nwith\tO\nprogressive\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nand\tO\nneutropenia\tB-Disease\n.\tO\n\nDISCUSSION\tO\n:\tO\nOur\tO\nseries\tO\nof\tO\npatients\tO\nis\tO\nrepresentative\tO\nof\tO\nthe\tO\nspectrum\tO\nof\tO\nimmunocompromised\tO\nchildren\tO\nat\tO\ngreatest\tO\nrisk\tO\nfor\tO\nsevere\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\n,\tO\nnamely\tO\nsolid\tO\n-\tO\norgan\tO\nand\tO\nbone\tO\nmarrow\tO\ntransplant\tO\nrecipients\tO\n,\tO\nneonates\tO\n,\tO\nand\tO\nchildren\tO\nwith\tO\nimmunodeficiency\tB-Disease\n.\tO\n\nAlthough\tO\nintravenous\tO\nribavirin\tB-Chemical\nwas\tO\nnot\tO\neffective\tO\nfor\tO\nall\tO\nchildren\tO\nwith\tO\nsevere\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\nin\tO\nthis\tO\nseries\tO\nor\tO\nin\tO\nthe\tO\nliterature\tO\n,\tO\ntherapy\tO\nis\tO\nunlikely\tO\nto\tO\nbe\tO\nof\tO\nbenefit\tO\nif\tO\nbegun\tO\nlate\tO\nin\tO\nthe\tO\ncourse\tO\nof\tO\nthe\tO\ninfection\tB-Disease\n.\tO\n\nEarly\tO\nidentification\tO\n,\tO\neg\tO\nby\tO\npolymerase\tO\nchain\tO\nreaction\tO\nof\tO\nthose\tO\npatients\tO\nat\tO\nrisk\tO\nof\tO\ndisseminated\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\nmay\tO\npermit\tO\nearlier\tO\nantiviral\tO\ntreatment\tO\nand\tO\nbetter\tO\nevaluation\tO\nof\tO\ntherapeutic\tO\nresponse\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nTwo\tO\nof\tO\n5\tO\nchildren\tO\nwith\tO\nsevere\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\ntreated\tO\nwith\tO\nintravenous\tO\nribavirin\tB-Chemical\nrecovered\tO\n.\tO\n\nThe\tO\navailability\tO\nof\tO\nnewer\tO\nrapid\tO\ndiagnostic\tO\ntechniques\tO\n,\tO\nsuch\tO\nas\tO\npolymerase\tO\nchain\tO\nreaction\tO\n,\tO\nmay\tO\nmake\tO\nearlier\tO\n,\tO\nmore\tO\neffective\tO\ntreatment\tO\nof\tO\nadenovirus\tB-Disease\ninfection\tI-Disease\npossible\tO\n.\tO\n\nGiven\tO\nthe\tO\nseriousness\tO\nand\tO\nincreasing\tO\nprevalence\tO\nof\tO\nadenovirus\tB-Disease\ndisease\tI-Disease\nin\tO\ncertain\tO\nhosts\tO\n,\tO\nespecially\tO\nchildren\tO\n,\tO\na\tO\nlarge\tO\n,\tO\nmulticenter\tO\nclinical\tO\ntrial\tO\nof\tO\npotentially\tO\nuseful\tO\nanti\tO\n-\tO\nadenoviral\tO\ntherapies\tO\n,\tO\nsuch\tO\nas\tO\nintravenous\tO\nribavirin\tB-Chemical\n,\tO\nis\tO\nclearly\tO\nrequired\tO\nto\tO\ndemonstrate\tO\nthe\tO\nmost\tO\neffective\tO\nand\tO\nleast\tO\ntoxic\tO\ntherapy\tO\n.\tO\n\nDelayed\tO\nasystolic\tB-Disease\ncardiac\tB-Disease\narrest\tI-Disease\nafter\tO\ndiltiazem\tB-Chemical\noverdose\tB-Disease\n;\tO\nresuscitation\tO\nwith\tO\nhigh\tO\ndose\tO\nintravenous\tO\ncalcium\tB-Chemical\n.\tO\n\nA\tO\n51\tO\nyear\tO\nold\tO\nman\tO\ntook\tO\na\tO\nmixed\tO\noverdose\tB-Disease\nincluding\tO\n1\tO\n.\tO\n8\tO\n-\tO\n3\tO\n.\tO\n6\tO\ng\tO\nof\tO\ndiltiazem\tB-Chemical\n,\tO\nparacetamol\tB-Chemical\n,\tO\naspirin\tB-Chemical\n,\tO\nisosorbide\tB-Chemical\nnitrate\tB-Chemical\n,\tO\nand\tO\nalcohol\tB-Chemical\n.\tO\n\nHe\tO\ninitially\tO\npresented\tO\nto\tO\nhospital\tO\nafter\tO\nsix\tO\nhours\tO\nwith\tO\nmild\tO\nhypotension\tB-Disease\nand\tO\nwas\tO\ntreated\tO\nwith\tO\nactivated\tO\ncharcoal\tO\nand\tO\nintravenous\tO\nfluids\tO\n.\tO\n\nEighteen\tO\nhours\tO\nafter\tO\nthe\tO\noverdose\tB-Disease\nhe\tO\nhad\tO\ntwo\tO\ngeneralised\tO\ntonic\tB-Disease\n-\tI-Disease\nclonic\tI-Disease\nseizures\tI-Disease\n.\tO\n\nThe\tO\npatient\tO\nremained\tO\nunresponsive\tO\nwith\tO\njunctional\tO\nbradycardia\tB-Disease\n,\tO\nunrecordable\tO\nblood\tO\npressure\tO\n,\tO\nand\tO\nthen\tO\nbecame\tO\nasystolic\tB-Disease\n.\tO\n\nHe\tO\nwas\tO\nresuscitated\tO\nwith\tO\nhigh\tO\ndose\tO\n(\tO\n13\tO\n.\tO\n5\tO\ng\tO\n)\tO\nintravenous\tO\ncalcium\tB-Chemical\nand\tO\nadrenaline\tB-Chemical\n(\tO\nepinephrine\tB-Chemical\n)\tO\n.\tO\n\nHe\tO\nrequired\tO\ninotropic\tO\nsupport\tO\nand\tO\ntemporary\tO\npacing\tO\nover\tO\nthe\tO\nnext\tO\n48\tO\nhours\tO\n.\tO\n\nThis\tO\ncase\tO\nsuggests\tO\nthere\tO\nis\tO\na\tO\nrole\tO\nfor\tO\naggressive\tO\nhigh\tO\ndose\tO\nintravenous\tO\ncalcium\tB-Chemical\ntherapy\tO\nin\tO\nsevere\tO\ndiltiazem\tB-Chemical\noverdose\tB-Disease\n,\tO\nparticularly\tO\nwith\tO\nthe\tO\nonset\tO\nof\tO\nasystole\tB-Disease\n.\tO\n\nIt\tO\nshould\tO\nbe\tO\nconsidered\tO\nearly\tO\nin\tO\ncases\tO\nof\tO\ncardiac\tB-Disease\narrest\tI-Disease\nafter\tO\ndiltiazem\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nThe\tO\ncase\tO\nalso\tO\nhighlights\tO\nthe\tO\nproblems\tO\nwith\tO\ndelayed\tO\ntoxicity\tB-Disease\nwhen\tO\nwhole\tO\nbowel\tO\nirrigation\tO\nis\tO\nnot\tO\nadministered\tO\n.\tO\n\nLow\tB-Chemical\n-\tI-Chemical\nmolecular\tI-Chemical\n-\tI-Chemical\nweight\tI-Chemical\nheparin\tI-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\npatients\tO\nwith\tO\nmechanical\tO\nheart\tO\nvalves\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\ninterruption\tO\nof\tO\noral\tO\nanticoagulant\tO\n(\tO\nOAC\tO\n)\tO\nadministration\tO\nis\tO\nsometimes\tO\nindicated\tO\nin\tO\npatients\tO\nwith\tO\nmechanical\tO\nheart\tO\nvalves\tO\n,\tO\nmainly\tO\nbefore\tO\nnoncardiac\tO\nsurgery\tO\n,\tO\nnon\tO\n-\tO\nsurgical\tO\ninterventions\tO\n,\tO\nand\tO\npregnancy\tO\n.\tO\n\nUnfractionated\tB-Chemical\nheparin\tI-Chemical\n(\tO\nUH\tB-Chemical\n)\tO\nis\tO\ncurrently\tO\nthe\tO\nsubstitute\tO\nfor\tO\nselected\tO\npatients\tO\n.\tO\n\nLow\tB-Chemical\n-\tI-Chemical\nmolecular\tI-Chemical\n-\tI-Chemical\nweight\tI-Chemical\nheparin\tI-Chemical\n(\tO\nLMWH\tB-Chemical\n)\tO\noffers\tO\ntheoretical\tO\nadvantages\tO\nover\tO\nUH\tB-Chemical\n,\tO\nbut\tO\nis\tO\nnot\tO\ncurrently\tO\nconsidered\tO\nin\tO\nclinical\tO\nguidelines\tO\nas\tO\nan\tO\nalternative\tO\nto\tO\nUH\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nprosthetic\tO\nvalves\tO\n.\tO\n\nHYPOTHESIS\tO\n:\tO\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\nreview\tO\nthe\tO\ndata\tO\naccumulated\tO\nso\tO\nfar\tO\non\tO\nthe\tO\nuse\tO\nof\tO\nLMWH\tB-Chemical\nin\tO\nthis\tO\npatient\tO\npopulation\tO\nand\tO\nto\tO\ndiscuss\tO\nits\tO\napplicability\tO\nin\tO\ncommon\tO\npractice\tO\n.\tO\n\nMETHODS\tO\n:\tO\nFor\tO\nthis\tO\npaper\tO\n,\tO\nthe\tO\ncurrent\tO\nmedical\tO\nliterature\tO\non\tO\nLMWH\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nmechanical\tO\nheart\tO\nvalves\tO\nwas\tO\nextensively\tO\nreviewed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThere\tO\nwere\tO\neight\tO\nseries\tO\nand\tO\nsix\tO\ncase\tO\nreports\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\nstudies\tO\nwas\tO\nrandomized\tO\n,\tO\nand\tO\nonly\tO\none\tO\nwas\tO\nprospective\tO\n.\tO\n\nData\tO\nto\tO\nestablish\tO\nthe\tO\nthromboembolic\tB-Disease\nrisk\tO\nwere\tO\nincomplete\tO\n.\tO\n\nAfter\tO\nexcluding\tO\ncase\tO\nreports\tO\n,\tO\nthe\tO\nfollowing\tO\ngroups\tO\nwere\tO\nconstructed\tO\n:\tO\n(\tO\na\tO\n)\tO\nshort\tO\n-\tO\nterm\tO\nadministration\tO\n,\tO\nafter\tO\nvalve\tO\ninsertion\tO\n(\tO\nn\tO\n=\tO\n212\tO\n)\tO\n;\tO\n(\tO\nb\tO\n)\tO\nshort\tO\n-\tO\nterm\tO\n,\tO\nperioperative\tO\n(\tO\nnoncardiac\tO\n)\tO\n/\tO\nperiprocedural\tO\n(\tO\nn\tO\n=\tO\n114\tO\n)\tO\n;\tO\n(\tO\nc\tO\n)\tO\nlong\tO\n-\tO\nterm\tO\n,\tO\ndue\tO\nto\tO\nintolerance\tO\nto\tO\nOAC\tO\n(\tO\nn\tO\n=\tO\n16\tO\n)\tO\n;\tO\n(\tO\nd\tO\n)\tO\nlong\tO\n-\tO\nterm\tO\n,\tO\nin\tO\npregnancy\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\n.\tO\n\nThe\tO\nincidence\tO\nrate\tO\nof\tO\nthromboembolism\tB-Disease\nwas\tO\n0\tO\n.\tO\n9\tO\n%\tO\nfor\tO\nall\tO\nthe\tO\nstudies\tO\nand\tO\n0\tO\n.\tO\n5\tO\n,\tO\n0\tO\n,\tO\n20\tO\n,\tO\nand\tO\n0\tO\n%\tO\nin\tO\ngroups\tO\na\tO\n,\tO\nb\tO\n,\tO\nc\tO\n,\tO\nand\tO\nd\tO\n,\tO\nrespectively\tO\n;\tO\nfor\tO\nhemorrhage\tB-Disease\n,\tO\nthe\tO\noverall\tO\nrate\tO\nwas\tO\n3\tO\n.\tO\n4\tO\n%\tO\n(\tO\n3\tO\n.\tO\n8\tO\n,\tO\n2\tO\n.\tO\n6\tO\n,\tO\n10\tO\n,\tO\nand\tO\n0\tO\n%\tO\nfor\tO\nthe\tO\nrespective\tO\ngroups\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\npatients\tO\nwith\tO\nmechanical\tO\nheart\tO\nvalves\tO\n,\tO\nshort\tO\n-\tO\nterm\tO\nLMWH\tB-Chemical\ntherapy\tO\ncompares\tO\nfavorably\tO\nwith\tO\nUH\tB-Chemical\n.\tO\n\nData\tO\non\tO\nmid\tO\n-\tO\nand\tO\nlong\tO\n-\tO\nterm\tO\nLMWH\tB-Chemical\nadministration\tO\nin\tO\nthese\tO\npatients\tO\nare\tO\nsparse\tO\n.\tO\n\nFurther\tO\nrandomized\tO\nstudies\tO\nare\tO\nneeded\tO\nto\tO\nconfirm\tO\nthe\tO\nsafety\tO\nand\tO\nprecise\tO\nindications\tO\nfor\tO\nthe\tO\nuse\tO\nof\tO\nLMWH\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nmechanical\tO\nheart\tO\nvalves\tO\n.\tO\n\nCardiac\tB-Disease\narrest\tI-Disease\nafter\tO\nintravenous\tO\nmetoclopramide\tB-Chemical\n-\tO\na\tO\ncase\tO\nof\tO\nfive\tO\nrepeated\tO\ninjections\tO\nof\tO\nmetoclopramide\tB-Chemical\ncausing\tO\nfive\tO\nepisodes\tO\nof\tO\ncardiac\tB-Disease\narrest\tI-Disease\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\npatient\tO\nwhere\tO\nintravenous\tO\ninjection\tO\nof\tO\nmetoclopramide\tB-Chemical\nwas\tO\nimmediately\tO\nfollowed\tO\nby\tO\nasystole\tB-Disease\nrepeatedly\tO\n.\tO\n\nThe\tO\npatient\tO\nreceived\tO\nmetoclopramide\tB-Chemical\n10\tO\nmg\tO\ni\tO\n.\tO\nv\tO\n.\tO\nfive\tO\ntimes\tO\nduring\tO\n48\tO\nh\tO\n.\tO\n\nAfter\tO\ninterviewing\tO\nthe\tO\nattending\tO\nnurses\tO\nand\tO\nreviewing\tO\nthe\tO\nwritten\tO\ndocumentation\tO\n,\tO\nit\tO\nis\tO\nclear\tO\nthat\tO\nevery\tO\nadministration\tO\nof\tO\nmetoclopramide\tB-Chemical\nwas\tO\nimmediately\tO\n(\tO\nwithin\tO\ns\tO\n)\tO\nfollowed\tO\nby\tO\nasystole\tB-Disease\n.\tO\n\nThe\tO\nasystole\tB-Disease\nlasted\tO\n15\tO\n-\tO\n30\tO\ns\tO\non\tO\nfour\tO\noccasions\tO\n,\tO\non\tO\none\tO\noccasion\tO\nit\tO\nlasted\tO\n2\tO\nmin\tO\n.\tO\n\nThe\tO\npatient\tO\nreceived\tO\natropine\tB-Chemical\n0\tO\n.\tO\n5\tO\n-\tO\n1\tO\nmg\tO\nand\tO\nchest\tO\ncompressions\tO\n,\tO\nbefore\tO\nsinus\tO\nrhythm\tO\nagain\tO\ntook\tO\nover\tO\n.\tO\n\nWe\tO\ninterpret\tO\nthis\tO\nas\tO\nepisodes\tO\nof\tO\ncardiac\tB-Disease\narrest\tI-Disease\ncaused\tO\nby\tO\nmetoclopramide\tB-Chemical\n.\tO\n\nThe\tO\nrapid\tO\ninjection\tO\nvia\tO\nthe\tO\ncentral\tO\nvenous\tO\nroute\tO\nand\tO\nthe\tO\nconcomitant\tO\ntapering\tO\nof\tO\ndopamine\tB-Chemical\ninfusion\tO\nmight\tO\nhave\tO\ncontributed\tO\nin\tO\nprecipitating\tO\nthe\tO\nadverse\tO\ndrug\tO\nreaction\tO\n.\tO\n\nImmunohistochemical\tO\nstudy\tO\non\tO\ninducible\tO\ntype\tO\nof\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\niNOS\tO\n)\tO\n,\tO\nbasic\tO\nfibroblast\tO\ngrowth\tO\nfactor\tO\n(\tO\nbFGF\tO\n)\tO\nand\tO\ntumor\tB-Disease\ngrowth\tO\nfactor\tO\n-\tO\nbeta1\tO\n(\tO\nTGF\tO\n-\tO\nbeta1\tO\n)\tO\nin\tO\narteritis\tB-Disease\ninduced\tO\nin\tO\nrats\tO\nby\tO\nfenoldopam\tB-Chemical\nand\tO\ntheophylline\tB-Chemical\n,\tO\nvasodilators\tO\n.\tO\n\nArteritis\tB-Disease\ninduced\tO\nin\tO\nrats\tO\nby\tO\nvasodilators\tO\n,\tO\nfenoldopam\tB-Chemical\nand\tO\ntheophylline\tB-Chemical\n,\tO\nwas\tO\nexamined\tO\nimmunohistochemically\tO\nfor\tO\nexpressions\tO\nof\tO\ninducible\tO\ntype\tO\nof\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsynthase\tO\n(\tO\niNOS\tO\n)\tO\n,\tO\nbasic\tO\nfibroblast\tO\ngrowth\tO\nfactor\tO\n(\tO\nbFGF\tO\n)\tO\nand\tO\ntumor\tB-Disease\ngrowth\tO\nfactor\tO\n-\tO\nbeta1\tO\n(\tO\nTGF\tO\n-\tO\nbeta1\tO\n)\tO\n.\tO\n\nRats\tO\nwere\tO\nadministered\tO\nfenoldopam\tB-Chemical\nfor\tO\n24\tO\nhours\tO\nby\tO\nintravenous\tO\ninfusion\tO\nwith\tO\nor\tO\nwithout\tO\nfollowing\tO\nrepeated\tO\ndaily\tO\noral\tO\nadministrations\tO\nof\tO\ntheophylline\tB-Chemical\n.\tO\n\nIrrespective\tO\nof\tO\ntheophylline\tB-Chemical\nadministration\tO\n,\tO\niNOS\tO\nantigens\tO\nwere\tO\nremarkably\tO\nabundant\tO\nin\tO\nED\tO\n-\tO\n1\tO\n-\tO\npositive\tO\ncells\tO\non\tO\nday\tO\n5\tO\nand\tO\n8\tO\npost\tO\n-\tO\nfenoldopam\tB-Chemical\n-\tO\ninfusion\tO\n(\tO\nDPI\tO\n)\tO\n;\tO\nbFGF\tO\nantigens\tO\nwere\tO\nremarkably\tO\nabundant\tO\nin\tO\nED\tO\n-\tO\n1\tO\n-\tO\npositive\tO\ncells\tO\non\tO\n1\tO\nand\tO\n3\tO\nDPI\tO\n;\tO\nTGF\tO\n-\tO\nbeta1\tO\nantigens\tO\nwere\tO\nobserved\tO\nin\tO\nED\tO\n-\tO\n1\tO\n-\tO\npositive\tO\ncells\tO\non\tO\nand\tO\nafter\tO\n5\tO\nDPI\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nthe\tO\npeak\tO\nexpression\tO\nof\tO\niNOS\tO\nantigen\tO\nwas\tO\nfollowed\tO\nby\tO\nthat\tO\nof\tO\nbFGF\tO\nantigen\tO\n,\tO\nand\tO\nbFGF\tO\nmay\tO\nhave\tO\na\tO\nsuppressive\tO\neffect\tO\non\tO\niNOS\tO\nexpression\tO\nin\tO\nthese\tO\nrat\tO\narteritis\tB-Disease\nmodels\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nTGF\tO\n-\tO\nbeta1\tO\nwas\tO\nnot\tO\nconsidered\tO\nto\tO\nhave\tO\na\tO\nsuppressive\tO\neffect\tO\non\tO\niNOS\tO\nexpression\tO\nin\tO\nthese\tO\nmodels\tO\n.\tO\n\nThe\tO\nstriatum\tO\nas\tO\na\tO\ntarget\tO\nfor\tO\nanti\tO\n-\tO\nrigor\tO\neffects\tO\nof\tO\nan\tO\nantagonist\tO\nof\tO\nmGluR1\tO\n,\tO\nbut\tO\nnot\tO\nan\tO\nagonist\tO\nof\tO\ngroup\tO\nII\tO\nmetabotropic\tO\nglutamate\tB-Chemical\nreceptors\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\nfind\tO\nout\tO\nwhether\tO\nthe\tO\nmetabotropic\tO\nreceptor\tO\n1\tO\n(\tO\nmGluR1\tO\n)\tO\nand\tO\ngroup\tO\nII\tO\nmGluRs\tO\n,\tO\nlocalized\tO\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nare\tO\ninvolved\tO\nin\tO\nantiparkinsonian\tO\n-\tO\nlike\tO\neffects\tO\nin\tO\nrats\tO\n.\tO\n\nHaloperidol\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\ninduced\tO\nparkinsonian\tB-Disease\n-\tO\nlike\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\n,\tO\nmeasured\tO\nas\tO\nan\tO\nincreased\tO\nresistance\tO\nof\tO\na\tO\nrat\tO\n'\tO\ns\tO\nhind\tO\nfoot\tO\nto\tO\npassive\tO\nflexion\tO\nand\tO\nextension\tO\nat\tO\nthe\tO\nankle\tO\njoint\tO\n.\tO\n\n(\tB-Chemical\nRS\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\naminoindan\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\ndicarboxylic\tI-Chemical\nacid\tI-Chemical\n(\tO\nAIDA\tB-Chemical\n;\tO\n0\tO\n.\tO\n5\tO\n-\tO\n15\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\n)\tO\n,\tO\na\tO\npotent\tO\nand\tO\nselective\tO\nmGluR1\tO\nantagonist\tO\n,\tO\nor\tO\n(\tB-Chemical\n2R\tI-Chemical\n,\tI-Chemical\n4R\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\naminopyrrolidine\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndicarboxylate\tI-Chemical\n(\tO\n2R\tB-Chemical\n,\tI-Chemical\n4R\tI-Chemical\n-\tI-Chemical\nAPDC\tI-Chemical\n;\tO\n7\tO\n.\tO\n5\tO\n-\tO\n15\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\n)\tO\n,\tO\na\tO\nselective\tO\ngroup\tO\nII\tO\nagonist\tO\n,\tO\nwas\tO\ninjected\tO\nbilaterally\tO\ninto\tO\nthe\tO\nstriatum\tO\nof\tO\nhaloperidol\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\n.\tO\n\nAIDA\tB-Chemical\nin\tO\ndoses\tO\nof\tO\n7\tO\n.\tO\n5\tO\n-\tO\n15\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\ndiminished\tO\nthe\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\n2R\tB-Chemical\n,\tI-Chemical\n4R\tI-Chemical\n-\tI-Chemical\nAPDC\tI-Chemical\ninjections\tO\nwere\tO\nineffective\tO\n.\tO\n\nThe\tO\npresent\tO\nresults\tO\nmay\tO\nsuggest\tO\nthat\tO\nthe\tO\nblockade\tO\nof\tO\nstriatal\tO\nmGluR1\tO\n,\tO\nbut\tO\nnot\tO\nthe\tO\nstimulation\tO\nof\tO\ngroup\tO\nII\tO\nmGluRs\tO\n,\tO\nmay\tO\nameliorate\tO\nparkinsonian\tB-Disease\nmuscle\tB-Disease\nrigidity\tI-Disease\n.\tO\n\nA\tO\nphase\tO\nII\tO\nstudy\tO\nof\tO\nthalidomide\tB-Chemical\nin\tO\nadvanced\tO\nmetastatic\tO\nrenal\tB-Disease\ncell\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\ntoxicity\tB-Disease\nand\tO\nactivity\tO\nof\tO\nthalidomide\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nadvanced\tO\nmetastatic\tO\nrenal\tB-Disease\ncell\tI-Disease\ncancer\tI-Disease\nand\tO\nto\tO\nmeasure\tO\nchanges\tO\nof\tO\none\tO\nangiogenic\tO\nfactor\tO\n,\tO\nvascular\tO\nendothelial\tO\ngrowth\tO\nfactor\tO\n(\tO\nVEGF\tO\n)\tO\n165\tO\n,\tO\nwith\tO\ntherapy\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\n29\tO\npatients\tO\nwere\tO\nenrolled\tO\non\tO\na\tO\nstudy\tO\nof\tO\nthalidomide\tB-Chemical\nusing\tO\nan\tO\nintra\tO\n-\tO\npatient\tO\ndose\tO\nescalation\tO\nschedule\tO\n.\tO\n\nPatients\tO\nbegan\tO\nthalidomide\tB-Chemical\nat\tO\n400\tO\nmg\tO\n/\tO\nd\tO\nand\tO\nescalated\tO\nas\tO\ntolerated\tO\nto\tO\n1200\tO\nmg\tO\n/\tO\nd\tO\nby\tO\nday\tO\n54\tO\n.\tO\n\nFifty\tO\n-\tO\nnine\tO\nper\tO\ncent\tO\nof\tO\npatients\tO\nhad\tO\nhad\tO\nprevious\tO\ntherapy\tO\nwith\tO\nIL\tO\n-\tO\n2\tO\nand\tO\n52\tO\n%\tO\nwere\tO\nperformance\tO\nstatus\tO\n2\tO\nor\tO\n3\tO\n.\tO\n\nSystemic\tO\nplasma\tO\nVEGF165\tO\nlevels\tO\nwere\tO\nmeasured\tO\nby\tO\ndual\tO\nmonoclonal\tO\nELISA\tO\nin\tO\n8\tO\npatients\tO\n.\tO\n\nRESULTS\tO\n:\tO\n24\tO\npatients\tO\nwere\tO\nevaluable\tO\nfor\tO\nresponse\tO\nwith\tO\none\tO\npartial\tO\nresponse\tO\nof\tO\n11\tO\nmonths\tO\nduration\tO\nof\tO\na\tO\npatient\tO\nwith\tO\nhepatic\tO\nand\tO\npulmonary\tO\nmetastases\tB-Disease\n(\tO\n4\tO\n%\tO\n)\tO\n,\tO\none\tO\nminor\tO\nresponse\tO\n,\tO\nand\tO\n2\tO\npatients\tO\nstable\tO\nfor\tO\nover\tO\n6\tO\nmonths\tO\n.\tO\n\nSomnolence\tB-Disease\nand\tO\nconstipation\tB-Disease\nwere\tO\nprominent\tO\ntoxicities\tB-Disease\nand\tO\nmost\tO\npatients\tO\ncould\tO\nnot\tO\ntolerate\tO\nthe\tO\n1200\tO\nmg\tO\n/\tO\nday\tO\ndose\tO\nlevel\tO\n.\tO\n\nSystemic\tO\nplasma\tO\nVEGF165\tO\nlevels\tO\ndid\tO\nnot\tO\nchange\tO\nwith\tO\ntherapy\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThese\tO\nresults\tO\nare\tO\nconsistent\tO\nwith\tO\na\tO\nlow\tO\nlevel\tO\nof\tO\nactivity\tO\nof\tO\nthalidomide\tB-Chemical\nin\tO\nrenal\tB-Disease\ncell\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nAdministration\tO\nof\tO\ndoses\tO\nover\tO\n800\tO\nmg\tO\n/\tO\nday\tO\nwas\tO\ndifficult\tO\nto\tO\nachieve\tO\nin\tO\nthis\tO\npatient\tO\npopulation\tO\n,\tO\nhowever\tO\nlower\tO\ndoses\tO\nwere\tO\npractical\tO\n.\tO\n\nThe\tO\ndose\tO\n-\tO\nresponse\tO\nrelationship\tO\n,\tO\nif\tO\nany\tO\n,\tO\nof\tO\nthalidomide\tB-Chemical\nfor\tO\nrenal\tB-Disease\ncell\tI-Disease\ncarcinoma\tI-Disease\nis\tO\nunclear\tO\n.\tO\n\nCan\tO\nlidocaine\tB-Chemical\nreduce\tO\nsuccinylcholine\tB-Chemical\ninduced\tO\npostoperative\tB-Disease\nmyalgia\tI-Disease\n?\tO\n\nThis\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ndetermine\tO\nthe\tO\neffect\tO\nof\tO\nlidocaine\tB-Chemical\npretreatment\tO\non\tO\nreduction\tO\nof\tO\nsuccinylcholine\tB-Chemical\n-\tO\ninduced\tO\nmyalgia\tB-Disease\nin\tO\npatients\tO\nundergoing\tO\ngeneral\tO\nanesthesia\tO\nfor\tO\ngynecological\tO\nsurgery\tO\n.\tO\n\nOne\tO\nhundred\tO\nand\tO\nthirty\tO\n-\tO\nfive\tO\npatients\tO\nwere\tO\nassigned\tO\nto\tO\none\tO\nof\tO\nthree\tO\ngroups\tO\nin\tO\na\tO\nprospective\tO\n,\tO\ndouble\tO\nblind\tO\n,\tO\nrandomized\tO\nmanner\tO\n.\tO\n\nGroup\tO\nPS\tO\n,\tO\nthe\tO\ncontrol\tO\ngroup\tO\n,\tO\nreceived\tO\nnormal\tO\nsaline\tO\nand\tO\nsuccinylcholine\tB-Chemical\n1\tO\n.\tO\n5\tO\nmg\tO\nx\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n;\tO\nGroup\tO\nLS\tO\n,\tO\nlidocaine\tB-Chemical\n1\tO\n.\tO\n5\tO\nmg\tO\nx\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\nand\tO\nsuccinylcholine\tB-Chemical\n1\tO\n.\tO\n5\tO\nmg\tO\nx\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n;\tO\nGroup\tO\nPR\tO\n,\tO\nnormal\tO\nsaline\tO\nand\tO\nrocuronium\tB-Chemical\n0\tO\n.\tO\n6\tO\nmg\tO\nx\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nMorphine\tB-Chemical\n0\tO\n.\tO\n1\tO\nmg\tO\nx\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\niv\tO\nwas\tO\ngiven\tO\nfor\tO\npremedication\tO\nand\tO\nall\tO\npatients\tO\nwere\tO\nmonitored\tO\nwith\tO\na\tO\nnoninvasive\tO\nblood\tO\npressure\tO\nmonitor\tO\n,\tO\nECG\tO\nand\tO\npulse\tO\noximetry\tO\n.\tO\n\nAnesthesia\tO\nwas\tO\ninduced\tO\nwith\tO\n5\tO\nmg\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\nthiopental\tB-Chemical\niv\tO\n.\tO\nfollowed\tO\nby\tO\nsuccinylcholine\tB-Chemical\n(\tO\nGroup\tO\nPS\tO\n,\tO\nLS\tO\n)\tO\nor\tO\nrocuronium\tB-Chemical\n(\tO\nGroup\tO\nPR\tO\n)\tO\nfor\tO\ntracheal\tO\nintubation\tO\n.\tO\n\nFollowing\tO\nadministration\tO\nof\tO\nthese\tO\nagents\tO\n,\tO\nthe\tO\npresence\tO\n,\tO\nand\tO\ndegree\tO\nof\tO\nfasciculation\tB-Disease\nwere\tO\nassessed\tO\nvisually\tO\non\tO\na\tO\nfour\tO\npoint\tO\nscale\tO\nby\tO\none\tO\ninvestigator\tO\nwho\tO\nwas\tO\nblinded\tO\nto\tO\nthe\tO\ndrug\tO\nadministered\tO\n.\tO\n\nThe\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\nof\tO\neach\tO\npatient\tO\nwere\tO\nmonitored\tO\non\tO\nnine\tO\noccasions\tO\n.\tO\n\nTwenty\tO\n-\tO\nfour\tO\nhours\tO\nlater\tO\n,\tO\nany\tO\nmyalgia\tB-Disease\nexperienced\tO\nwas\tO\nassessed\tO\naccording\tO\nto\tO\na\tO\nstructured\tO\nquestionaire\tO\nand\tO\ngraded\tO\nby\tO\na\tO\nfour\tO\npoint\tO\nscale\tO\nby\tO\none\tO\ninvestigator\tO\nblinded\tO\nto\tO\nthe\tO\nintraoperative\tO\nmanagement\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nmuscle\tB-Disease\nfasciculation\tI-Disease\nwas\tO\nnot\tO\nfound\tO\nin\tO\nGroup\tO\nPR\tO\nwhile\tO\nthe\tO\npatients\tO\nin\tO\nGroup\tO\nLS\tO\nhad\tO\na\tO\nlower\tO\nincidence\tO\nof\tO\nmuscle\tB-Disease\nfasciculation\tI-Disease\nthan\tO\nthose\tO\nin\tO\nGroup\tO\nPS\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nAt\tO\n24\tO\nh\tO\n,\tO\nthe\tO\nincidence\tO\nof\tO\nmyalgia\tB-Disease\nwas\tO\nhigher\tO\nin\tO\nGroup\tO\nPS\tO\nthan\tO\nin\tO\nGroup\tO\nLS\tO\nand\tO\nPR\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nA\tO\ncorrelation\tO\nwas\tO\nnot\tO\nfound\tO\nbetween\tO\nthe\tO\nincidence\tO\nof\tO\nmyalgia\tB-Disease\nand\tO\nthe\tO\noccurrence\tO\nof\tO\nmuscle\tB-Disease\nfasciculation\tI-Disease\n.\tO\n\nThe\tO\nchanges\tO\nin\tO\nsystolic\tO\nand\tO\ndiastolic\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\nwere\tO\nnot\tO\nsignificant\tO\namong\tO\nthe\tO\nthree\tO\ngroups\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nwhere\tO\nsuccinylcholine\tB-Chemical\nis\tO\nused\tO\n,\tO\nlidocaine\tB-Chemical\nis\tO\nproven\tO\nto\tO\nbe\tO\nthe\tO\nuseful\tO\npretreatment\tO\nagent\tO\nfor\tO\nthe\tO\nreduction\tO\nof\tO\npostoperative\tB-Disease\nmyalgia\tI-Disease\n.\tO\n\nReduced\tO\nsodium\tB-Chemical\nchannel\tO\ndensity\tO\n,\tO\naltered\tO\nvoltage\tO\ndependence\tO\nof\tO\ninactivation\tO\n,\tO\nand\tO\nincreased\tO\nsusceptibility\tO\nto\tO\nseizures\tB-Disease\nin\tO\nmice\tO\nlacking\tO\nsodium\tB-Chemical\nchannel\tO\nbeta\tO\n2\tO\n-\tO\nsubunits\tO\n.\tO\n\nSodium\tB-Chemical\nchannel\tO\nbeta\tO\n-\tO\nsubunits\tO\nmodulate\tO\nchannel\tO\ngating\tO\n,\tO\nassembly\tO\n,\tO\nand\tO\ncell\tO\nsurface\tO\nexpression\tO\nin\tO\nheterologous\tO\ncell\tO\nsystems\tO\n.\tO\n\nWe\tO\ngenerated\tO\nbeta2\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nto\tO\ninvestigate\tO\nthe\tO\nrole\tO\nof\tO\nbeta2\tO\nin\tO\ncontrol\tO\nof\tO\nsodium\tB-Chemical\nchannel\tO\ndensity\tO\n,\tO\nlocalization\tO\n,\tO\nand\tO\nfunction\tO\nin\tO\nneurons\tO\nin\tO\nvivo\tO\n.\tO\n\nMeasurements\tO\nof\tO\n[\tO\n(\tO\n3\tO\n)\tO\nH\tO\n]\tO\nsaxitoxin\tB-Chemical\n(\tO\nSTX\tB-Chemical\n)\tO\nbinding\tO\nshowed\tO\na\tO\nsignificant\tO\nreduction\tO\nin\tO\nthe\tO\nlevel\tO\nof\tO\nplasma\tO\nmembrane\tO\nsodium\tB-Chemical\nchannels\tO\nin\tO\nbeta2\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nneurons\tO\n.\tO\n\nThe\tO\nloss\tO\nof\tO\nbeta2\tO\nresulted\tO\nin\tO\nnegative\tO\nshifts\tO\nin\tO\nthe\tO\nvoltage\tO\ndependence\tO\nof\tO\ninactivation\tO\nas\tO\nwell\tO\nas\tO\nsignificant\tO\ndecreases\tO\nin\tO\nsodium\tB-Chemical\ncurrent\tO\ndensity\tO\nin\tO\nacutely\tO\ndissociated\tO\nhippocampal\tO\nneurons\tO\n.\tO\n\nThe\tO\nintegral\tO\nof\tO\nthe\tO\ncompound\tO\naction\tO\npotential\tO\nin\tO\noptic\tO\nnerve\tO\nwas\tO\nsignificantly\tO\nreduced\tO\n,\tO\nand\tO\nthe\tO\nthreshold\tO\nfor\tO\naction\tO\npotential\tO\ngeneration\tO\nwas\tO\nincreased\tO\n,\tO\nindicating\tO\na\tO\nreduction\tO\nin\tO\nthe\tO\nlevel\tO\nof\tO\nfunctional\tO\nplasma\tO\nmembrane\tO\nsodium\tB-Chemical\nchannels\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthe\tO\nconduction\tO\nvelocity\tO\n,\tO\nthe\tO\nnumber\tO\nand\tO\nsize\tO\nof\tO\naxons\tO\nin\tO\nthe\tO\noptic\tO\nnerve\tO\n,\tO\nand\tO\nthe\tO\nspecific\tO\nlocalization\tO\nof\tO\nNa\tB-Chemical\n(\tO\nv\tO\n)\tO\n1\tO\n.\tO\n6\tO\nchannels\tO\nin\tO\nthe\tO\nnodes\tO\nof\tO\nRanvier\tO\nwere\tO\nunchanged\tO\n.\tO\n\nbeta2\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\ndisplayed\tO\nincreased\tO\nsusceptibility\tO\nto\tO\nseizures\tB-Disease\n,\tO\nas\tO\nindicated\tO\nby\tO\nreduced\tO\nlatency\tO\nand\tO\nthreshold\tO\nfor\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n,\tO\nbut\tO\nseemed\tO\nnormal\tO\nin\tO\nother\tO\nneurological\tO\ntests\tO\n.\tO\n\nOur\tO\nobservations\tO\nshow\tO\nthat\tO\nbeta2\tO\n-\tO\nsubunits\tO\nplay\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\nregulation\tO\nof\tO\nsodium\tB-Chemical\nchannel\tO\ndensity\tO\nand\tO\nfunction\tO\nin\tO\nneurons\tO\nin\tO\nvivo\tO\nand\tO\nare\tO\nrequired\tO\nfor\tO\nnormal\tO\naction\tO\npotential\tO\ngeneration\tO\nand\tO\ncontrol\tO\nof\tO\nexcitability\tO\n.\tO\n\nAcute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nwith\tO\nconcurrent\tO\nbupropion\tB-Chemical\nand\tO\ncarbimazole\tB-Chemical\ntherapy\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nfatal\tO\nliver\tB-Disease\nfailure\tI-Disease\npossibly\tO\nassociated\tO\nwith\tO\nconcurrent\tO\nuse\tO\nof\tO\nbupropion\tB-Chemical\nand\tO\ncarbimazole\tB-Chemical\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n41\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nChinese\tO\nman\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nhyperthyroidism\tB-Disease\nhad\tO\nbeen\tO\ntreated\tO\nwith\tO\ncarbimazole\tB-Chemical\nand\tO\npropranolol\tB-Chemical\nfor\tO\nthe\tO\npast\tO\n5\tO\nyears\tO\n.\tO\n\nHe\tO\nreceived\tO\na\tO\n10\tO\n-\tO\nday\tO\ncourse\tO\nof\tO\nbupropion\tB-Chemical\nas\tO\nan\tO\naid\tO\nfor\tO\nsmoking\tO\ncessation\tO\n10\tO\nweeks\tO\nprior\tO\nto\tO\npresentation\tO\n.\tO\n\nHe\tO\ndeveloped\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nwith\tO\nrapid\tO\ndeterioration\tO\nof\tO\nrenal\tO\nfunction\tO\n.\tO\n\nLiver\tO\nbiopsy\tO\nshowed\tO\nevidence\tO\nof\tO\nnonspecific\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nacute\tI-Disease\nliver\tI-Disease\ninjury\tI-Disease\n.\tO\n\nHis\tO\ncondition\tO\nwas\tO\nfurther\tO\ncomplicated\tO\nby\tO\nsepsis\tB-Disease\nand\tO\ncoagulopathy\tB-Disease\n.\tO\n\nDeath\tO\nresulted\tO\n19\tO\ndays\tO\nafter\tO\nthe\tO\nonset\tO\nof\tO\nsymptoms\tO\n.\tO\n\nThe\tO\nlikelihood\tO\nthat\tO\nbupropion\tB-Chemical\ninduced\tO\nhepatotoxicity\tB-Disease\nin\tO\nour\tO\npatient\tO\nwas\tO\npossible\tO\n,\tO\nbased\tO\non\tO\nthe\tO\nNaranjo\tO\nprobability\tO\nscale\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nAlthough\tO\nthere\tO\nis\tO\nincreasing\tO\nevidence\tO\nof\tO\nhepatotoxicity\tB-Disease\ninduced\tO\nby\tO\nbupropion\tB-Chemical\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\ncase\tO\nof\tO\nfatality\tO\nthat\tO\ncould\tO\nhave\tO\nresulted\tO\nfrom\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nin\tO\na\tO\npatient\tO\nreceiving\tO\nbupropion\tB-Chemical\nwhile\tO\non\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ncarbimazole\tB-Chemical\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nClinicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthe\tO\npossibility\tO\nof\tO\nacute\tB-Disease\nliver\tI-Disease\ninsult\tI-Disease\ninduced\tO\nby\tO\nbupropion\tB-Chemical\ngiven\tO\nconcurrently\tO\nwith\tO\nother\tO\nhepatotoxic\tB-Disease\ndrugs\tO\n.\tO\n\nPyeloureteral\tO\nfilling\tO\ndefects\tO\nassociated\tO\nwith\tO\nsystemic\tO\nanticoagulation\tO\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nThe\tO\netiology\tO\nof\tO\npyeloureteritis\tB-Disease\ncystica\tI-Disease\nhas\tO\nlong\tO\nbeen\tO\nattributed\tO\nto\tO\nchronic\tO\ninfection\tB-Disease\nand\tO\ninflammation\tB-Disease\n.\tO\n\nA\tO\ncase\tO\nis\tO\npresented\tO\nthat\tO\nis\tO\nunique\tO\nin\tO\nthat\tO\nthe\tO\nacute\tO\nonset\tO\nand\tO\nthe\tO\nrapid\tO\nresolution\tO\nof\tO\npyeloureteral\tO\nfilling\tO\ndefects\tO\nin\tO\nthis\tO\npatient\tO\nwere\tO\ndocumented\tO\nby\tO\nradiography\tO\n.\tO\n\nThere\tO\nis\tO\nno\tO\nevidence\tO\nof\tO\nantecedent\tO\nor\tO\nconcurrent\tO\ninfection\tB-Disease\nin\tO\nthis\tO\npatient\tO\n.\tO\n\nThe\tO\ndisease\tO\noccurred\tO\nsubsequent\tO\nto\tO\nthe\tO\ninitiation\tO\nof\tO\nheparin\tB-Chemical\ntherapy\tO\nfor\tO\nsuspected\tO\npelvic\tO\nthrombophlebitis\tB-Disease\nand\tO\ncleared\tO\nrapidly\tO\nsubsequent\tO\nto\tO\nits\tO\ndiscontinuation\tO\n.\tO\n\nThe\tO\nrate\tO\nof\tO\nresolution\tO\nof\tO\nthe\tO\nradiographic\tO\nfindings\tO\nmay\tO\nbe\tO\nhelpful\tO\nin\tO\ndistinguishing\tO\nbetween\tO\ntrue\tO\npyeloureteritis\tB-Disease\ncystica\tI-Disease\nand\tO\nsubmucosal\tB-Disease\nhemorrhage\tI-Disease\n.\tO\n\nNephrotoxic\tB-Disease\neffects\tO\nin\tO\nhigh\tO\n-\tO\nrisk\tO\npatients\tO\nundergoing\tO\nangiography\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nuse\tO\nof\tO\niodinated\tO\ncontrast\tO\nmedium\tO\ncan\tO\nresult\tO\nin\tO\nnephropathy\tB-Disease\n.\tO\n\nWhether\tO\niso\tO\n-\tO\nosmolar\tO\ncontrast\tO\nmedium\tO\nis\tO\nless\tO\nnephrotoxic\tB-Disease\nthan\tO\nlow\tO\n-\tO\nosmolar\tO\ncontrast\tO\nmedium\tO\nin\tO\nhigh\tO\n-\tO\nrisk\tO\npatients\tO\nis\tO\nuncertain\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nconducted\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nprospective\tO\n,\tO\nmulticenter\tO\nstudy\tO\ncomparing\tO\nthe\tO\nnephrotoxic\tB-Disease\neffects\tO\nof\tO\nan\tO\niso\tO\n-\tO\nosmolar\tO\n,\tO\ndimeric\tO\n,\tO\nnonionic\tO\ncontrast\tO\nmedium\tO\n,\tO\niodixanol\tB-Chemical\n,\tO\nwith\tO\nthose\tO\nof\tO\na\tO\nlow\tO\n-\tO\nosmolar\tO\n,\tO\nnonionic\tO\n,\tO\nmonomeric\tO\ncontrast\tO\nmedium\tO\n,\tO\niohexol\tB-Chemical\n.\tO\n\nThe\tO\nstudy\tO\ninvolved\tO\n129\tO\npatients\tO\nwith\tO\ndiabetes\tB-Disease\nwith\tO\nserum\tO\ncreatinine\tB-Chemical\nconcentrations\tO\nof\tO\n1\tO\n.\tO\n5\tO\nto\tO\n3\tO\n.\tO\n5\tO\nmg\tO\nper\tO\ndeciliter\tO\nwho\tO\nunderwent\tO\ncoronary\tO\nor\tO\naortofemoral\tO\nangiography\tO\n.\tO\n\nThe\tO\nprimary\tO\nend\tO\npoint\tO\nwas\tO\nthe\tO\npeak\tO\nincrease\tO\nfrom\tO\nbase\tO\nline\tO\nin\tO\nthe\tO\ncreatinine\tB-Chemical\nconcentration\tO\nduring\tO\nthe\tO\nthree\tO\ndays\tO\nafter\tO\nangiography\tO\n.\tO\n\nOther\tO\nend\tO\npoints\tO\nwere\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\ncreatinine\tB-Chemical\nconcentration\tO\nof\tO\n0\tO\n.\tO\n5\tO\nmg\tO\nper\tO\ndeciliter\tO\nor\tO\nmore\tO\n,\tO\nan\tO\nincrease\tO\nof\tO\n1\tO\n.\tO\n0\tO\nmg\tO\nper\tO\ndeciliter\tO\nor\tO\nmore\tO\n,\tO\nand\tO\na\tO\nchange\tO\nin\tO\nthe\tO\ncreatinine\tB-Chemical\nconcentration\tO\nfrom\tO\nday\tO\n0\tO\nto\tO\nday\tO\n7\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\ncreatinine\tB-Chemical\nconcentration\tO\nincreased\tO\nsignificantly\tO\nless\tO\nin\tO\npatients\tO\nwho\tO\nreceived\tO\niodixanol\tB-Chemical\n.\tO\n\nFrom\tO\nday\tO\n0\tO\nto\tO\nday\tO\n3\tO\n,\tO\nthe\tO\nmean\tO\npeak\tO\nincrease\tO\nin\tO\ncreatinine\tB-Chemical\nwas\tO\n0\tO\n.\tO\n13\tO\nmg\tO\nper\tO\ndeciliter\tO\nin\tO\nthe\tO\niodixanol\tB-Chemical\ngroup\tO\nand\tO\n0\tO\n.\tO\n55\tO\nmg\tO\nper\tO\ndeciliter\tO\nin\tO\nthe\tO\niohexol\tB-Chemical\ngroup\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n001\tO\n;\tO\nthe\tO\nincrease\tO\nwith\tO\niodixanol\tB-Chemical\nminus\tO\nthe\tO\nincrease\tO\nwith\tO\niohexol\tB-Chemical\n,\tO\n-\tO\n0\tO\n.\tO\n42\tO\nmg\tO\nper\tO\ndeciliter\tO\n[\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n-\tO\n0\tO\n.\tO\n73\tO\nto\tO\n-\tO\n0\tO\n.\tO\n22\tO\n]\tO\n)\tO\n.\tO\n\nTwo\tO\nof\tO\nthe\tO\n64\tO\npatients\tO\nin\tO\nthe\tO\niodixanol\tB-Chemical\ngroup\tO\n(\tO\n3\tO\npercent\tO\n)\tO\nhad\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\ncreatinine\tB-Chemical\nconcentration\tO\nof\tO\n0\tO\n.\tO\n5\tO\nmg\tO\nper\tO\ndeciliter\tO\nor\tO\nmore\tO\n,\tO\nas\tO\ncompared\tO\nwith\tO\n17\tO\nof\tO\nthe\tO\n65\tO\npatients\tO\nin\tO\nthe\tO\niohexol\tB-Chemical\ngroup\tO\n(\tO\n26\tO\npercent\tO\n)\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n002\tO\n;\tO\nodds\tO\nratio\tO\nfor\tO\nsuch\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\niodixanol\tB-Chemical\ngroup\tO\n,\tO\n0\tO\n.\tO\n09\tO\n[\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n02\tO\nto\tO\n0\tO\n.\tO\n41\tO\n]\tO\n)\tO\n.\tO\n\nNo\tO\npatient\tO\nreceiving\tO\niodixanol\tB-Chemical\nhad\tO\nan\tO\nincrease\tO\nof\tO\n1\tO\n.\tO\n0\tO\nmg\tO\nper\tO\ndeciliter\tO\nor\tO\nmore\tO\n,\tO\nbut\tO\n10\tO\npatients\tO\nin\tO\nthe\tO\niohexol\tB-Chemical\ngroup\tO\n(\tO\n15\tO\npercent\tO\n)\tO\ndid\tO\n.\tO\n\nThe\tO\nmean\tO\nchange\tO\nin\tO\nthe\tO\ncreatinine\tB-Chemical\nconcentration\tO\nfrom\tO\nday\tO\n0\tO\nto\tO\nday\tO\n7\tO\nwas\tO\n0\tO\n.\tO\n07\tO\nmg\tO\nper\tO\ndeciliter\tO\nin\tO\nthe\tO\niodixanol\tB-Chemical\ngroup\tO\nand\tO\n0\tO\n.\tO\n24\tO\nmg\tO\nper\tO\ndeciliter\tO\nin\tO\nthe\tO\niohexol\tB-Chemical\ngroup\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n003\tO\n;\tO\nvalue\tO\nin\tO\nthe\tO\niodixanol\tB-Chemical\ngroup\tO\nminus\tO\nthe\tO\nvalue\tO\nin\tO\nthe\tO\niohexol\tB-Chemical\ngroup\tO\n,\tO\n-\tO\n0\tO\n.\tO\n17\tO\nmg\tO\nper\tO\ndeciliter\tO\n[\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n-\tO\n0\tO\n.\tO\n34\tO\nto\tO\n-\tO\n0\tO\n.\tO\n07\tO\n]\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nNephropathy\tB-Disease\ninduced\tO\nby\tO\ncontrast\tO\nmedium\tO\nmay\tO\nbe\tO\nless\tO\nlikely\tO\nto\tO\ndevelop\tO\nin\tO\nhigh\tO\n-\tO\nrisk\tO\npatients\tO\nwhen\tO\niodixanol\tB-Chemical\nis\tO\nused\tO\nrather\tO\nthan\tO\na\tO\nlow\tO\n-\tO\nosmolar\tO\n,\tO\nnonionic\tO\ncontrast\tO\nmedium\tO\n.\tO\n\nProtective\tO\neffect\tO\nof\tO\nedaravone\tB-Chemical\nagainst\tO\nstreptomycin\tB-Chemical\n-\tO\ninduced\tO\nvestibulotoxicity\tB-Disease\nin\tO\nthe\tO\nguinea\tO\npig\tO\n.\tO\n\nThis\tO\nstudy\tO\ninvestigated\tO\nalleviation\tO\nof\tO\nstreptomycin\tB-Chemical\n-\tO\ninduced\tO\nvestibulotoxicity\tB-Disease\nby\tO\nedaravone\tB-Chemical\nin\tO\nguinea\tO\npigs\tO\n.\tO\n\nEdaravone\tB-Chemical\n,\tO\na\tO\nfree\tO\nradical\tO\nscavenger\tO\n,\tO\nhas\tO\npotent\tO\nfree\tO\nradical\tO\nquenching\tO\naction\tO\nand\tO\nis\tO\nused\tO\nin\tO\nclinical\tO\npractice\tO\nto\tO\ntreat\tO\ncerebral\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nStreptomycin\tB-Chemical\nwas\tO\nadministered\tO\nto\tO\nthe\tO\ninner\tO\near\tO\nby\tO\nosmotic\tO\npump\tO\nfor\tO\n24\tO\nh\tO\n,\tO\nand\tO\nedaravone\tB-Chemical\n(\tO\nn\tO\n=\tO\n8\tO\n)\tO\nor\tO\nsaline\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nwas\tO\nintraperitoneally\tO\ninjected\tO\nonce\tO\na\tO\nday\tO\nfor\tO\n7\tO\ndays\tO\n.\tO\n\nWe\tO\nobserved\tO\nhorizontal\tO\nvestibulo\tO\n-\tO\nocular\tO\nreflex\tO\nas\tO\na\tO\nmarker\tO\nof\tO\npostoperative\tO\nvestibular\tO\nfunction\tO\n.\tO\n\nAnimals\tO\ninjected\tO\nwith\tO\nsaline\tO\nshowed\tO\nstatistically\tO\nsmaller\tO\ngains\tO\nthan\tO\nthose\tO\ninjected\tO\nwith\tO\nedaravone\tB-Chemical\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nedaravone\tB-Chemical\nsuppresses\tO\nstreptomycin\tB-Chemical\n-\tO\ninduced\tO\nvestibulotoxicity\tB-Disease\n.\tO\n\nLevodopa\tB-Chemical\n-\tO\ninduced\tO\noromandibular\tO\ndystonia\tB-Disease\nin\tO\nprogressive\tB-Disease\nsupranuclear\tI-Disease\npalsy\tI-Disease\n.\tO\n\nLevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nhave\tO\nbeen\tO\nreported\tO\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nand\tO\nmultiple\tB-Disease\nsystem\tI-Disease\natrophy\tI-Disease\n.\tO\n\nCranial\tO\ndystonias\tB-Disease\nare\tO\nrare\tO\nin\tO\npatients\tO\nwith\tO\nprogressive\tB-Disease\nsupranuclear\tI-Disease\npalsy\tI-Disease\n(\tO\nPSP\tB-Disease\n)\tO\n.\tO\n\nIn\tO\nthis\tO\nreport\tO\nwe\tO\ndescribe\tO\nan\tO\nunusual\tO\ncase\tO\nof\tO\nreversible\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\nOromandibular\tB-Disease\ndystonia\tI-Disease\n(\tO\nOMD\tB-Disease\n)\tO\nin\tO\na\tO\nPSP\tB-Disease\npatient\tO\nto\tO\nhighlight\tO\nthe\tO\nimportance\tO\nof\tO\nrecognizing\tO\nthis\tO\ndrug\tO\nrelated\tO\ncomplication\tO\nin\tO\nthe\tO\nmanagement\tO\nof\tO\nPSP\tB-Disease\n,\tO\nand\tO\ndiscuss\tO\nthe\tO\npossible\tO\nunderlying\tO\npathophysiology\tO\n.\tO\n\nCase\tO\nreport\tO\n:\tO\nDexatrim\tB-Chemical\n(\tO\nPhenylpropanolamine\tB-Chemical\n)\tO\nas\tO\na\tO\ncause\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nPhenylpropanolamine\tB-Chemical\n(\tO\nPPA\tB-Chemical\n)\tO\nis\tO\na\tO\nsympathetic\tO\namine\tB-Chemical\nused\tO\nin\tO\nover\tO\n-\tO\nthe\tO\n-\tO\ncounter\tO\ncold\tO\nremedies\tO\nand\tO\nweight\tO\n-\tO\ncontrol\tO\npreparations\tO\nworldwide\tO\n.\tO\n\nIts\tO\nuse\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nhypertensive\tB-Disease\nepisodes\tO\nand\tO\nhemorrhagic\tB-Disease\nstrokes\tI-Disease\nin\tO\nyounger\tO\nwomen\tO\n.\tO\n\nSeveral\tO\nreports\tO\nhave\tO\nlinked\tO\nthe\tO\nabuse\tO\nof\tO\nPPA\tB-Chemical\nwith\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\n,\tO\nespecially\tO\nwhen\tO\noverdose\tB-Disease\nis\tO\ninvolved\tO\n.\tO\n\nWe\tO\nreport\tO\nhere\tO\nthe\tO\nfirst\tO\ncase\tO\nof\tO\nDexatrim\tB-Chemical\n(\tO\nPPA\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\nin\tO\na\tO\nyoung\tO\nwoman\tO\nwho\tO\nwas\tO\nusing\tO\nit\tO\nat\tO\nrecommended\tO\ndoses\tO\nfor\tO\nweight\tO\ncontrol\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nwe\tO\nreview\tO\nthe\tO\n7\tO\nother\tO\ncases\tO\nof\tO\nPPA\tB-Chemical\nrelated\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\nthat\tO\nhave\tO\nbeen\tO\nreported\tO\nso\tO\nfar\tO\n.\tO\n\nPhysicians\tO\nand\tO\npatients\tO\nshould\tO\nbe\tO\nalert\tO\nto\tO\nthe\tO\npotential\tO\ncardiac\tO\nrisk\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nPPA\tB-Chemical\n,\tO\neven\tO\nat\tO\ndoses\tO\ngenerally\tO\nconsidered\tO\nto\tO\nbe\tO\nsafe\tO\n.\tO\n\nDifferential\tO\ndiagnosis\tO\nof\tO\nhigh\tO\nserum\tO\ncreatine\tB-Chemical\nkinase\tO\nlevels\tO\nin\tO\nsystemic\tB-Disease\nlupus\tI-Disease\nerythematosus\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\nclinical\tO\nand\tO\nbioptic\tO\nfindings\tO\nfor\tO\na\tO\n57\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nsevere\tO\nchloroquine\tB-Chemical\n-\tO\ninduced\tO\nmyopathy\tB-Disease\n.\tO\n\nSince\tO\n1989\tO\n,\tO\nshe\tO\nhad\tO\nbeen\tO\nsuffering\tO\nfrom\tO\nsystemic\tB-Disease\nlupus\tI-Disease\nerythematosus\tI-Disease\n(\tO\nSLE\tB-Disease\n)\tO\nwith\tO\nrenal\tB-Disease\ninvolvement\tI-Disease\nand\tO\nundergone\tO\nperiods\tO\nof\tO\ntreatment\tO\nwith\tO\nazathioprine\tB-Chemical\nand\tO\ncyclophosphamide\tB-Chemical\n.\tO\n\nAdditional\tO\ntherapy\tO\nwith\tO\nchloroquine\tB-Chemical\n(\tO\nCQ\tB-Chemical\n)\tO\nwas\tO\nstarted\tO\nbecause\tO\nof\tO\narthralgia\tB-Disease\n.\tO\n\nAt\tO\nthe\tO\nsame\tO\ntime\tO\n,\tO\nslightly\tO\nincreased\tO\ncreatine\tB-Chemical\nkinase\tO\n(\tO\nCK\tO\n)\tO\nlevels\tO\nwere\tO\nnoted\tO\n.\tO\n\nMyositis\tB-Disease\nwas\tO\nsuspected\tO\n,\tO\nand\tO\nthe\tO\npatient\tO\nwas\tO\ntreated\tO\nwith\tO\nsteroids\tB-Chemical\n.\tO\n\nThe\tO\nCK\tO\nincrease\tO\npersisted\tO\n,\tO\nhowever\tO\n,\tO\nand\tO\nshe\tO\ndeveloped\tO\nprogressive\tO\nmuscular\tB-Disease\nweakness\tI-Disease\nand\tO\nmuscular\tB-Disease\natrophy\tI-Disease\n.\tO\n\nRoutine\tO\ncontrols\tO\nrevealed\tO\nmarkedly\tO\nelevated\tO\nCK\tO\nlevels\tO\nof\tO\n1\tO\n,\tO\n700\tO\nU\tO\n/\tO\nl\tO\n.\tO\n\nThe\tO\nneurological\tO\nand\tO\nelectrophysiological\tO\nfindings\tO\nwere\tO\nnot\tO\ntypical\tO\nof\tO\nmyositis\tB-Disease\n.\tO\n\nThus\tO\n,\tO\nmuscle\tO\nbiopsy\tO\nof\tO\nthe\tO\ndeltoid\tO\nmuscle\tO\nwas\tO\nperformed\tO\nin\tO\norder\tO\nto\tO\nexclude\tO\npolymyositis\tB-Disease\nor\tO\ntoxic\tO\nmyopathy\tB-Disease\n.\tO\n\nAs\tO\nit\tO\nrevealed\tO\nchloroquine\tB-Chemical\n-\tO\ninduced\tO\nmyopathy\tB-Disease\n,\tO\nmedication\tO\nwas\tO\nstopped\tO\n.\tO\n\nDiscriminating\tO\nbetween\tO\nprimary\tO\nSLE\tB-Disease\n-\tO\ninduced\tO\naffection\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nmusculoskeletal\tI-Disease\nsystem\tI-Disease\nand\tO\ndrug\tO\n-\tO\ninduced\tO\nside\tO\neffects\tO\nis\tO\nimportant\tO\nfor\tO\nappropriate\tO\ntreatment\tO\nof\tO\nSLE\tB-Disease\npatients\tO\n.\tO\n\nSeizure\tB-Disease\nassociated\tO\nwith\tO\nsleep\tB-Disease\ndeprivation\tI-Disease\nand\tO\nsustained\tO\n-\tO\nrelease\tO\nbupropion\tB-Chemical\n.\tO\n\nThis\tO\ncase\tO\nreport\tO\ndescribes\tO\na\tO\ngeneralized\tO\nseizure\tB-Disease\nassociated\tO\nwith\tO\nsustained\tO\n-\tO\nrelease\tO\nbupropion\tB-Chemical\nuse\tO\nand\tO\nsleep\tB-Disease\ndeprivation\tI-Disease\n.\tO\n\nThe\tO\nsubject\tO\n,\tO\na\tO\n31\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfemale\tO\nsmoker\tO\n,\tO\nwas\tO\nparticipating\tO\nin\tO\na\tO\nclinical\tO\ntrial\tO\nevaluating\tO\nan\tO\ninvestigational\tO\nmedication\tO\nfor\tO\nsmoking\tO\ncessation\tO\nthat\tO\nused\tO\nsustained\tO\n-\tO\nrelease\tO\nbupropion\tB-Chemical\nas\tO\nan\tO\nactive\tO\ncontrol\tO\n.\tO\n\nAfter\tO\n5\tO\nweeks\tO\nof\tO\nbupropion\tB-Chemical\nuse\tO\n,\tO\nthe\tO\nsubject\tO\nexperienced\tO\na\tO\ngeneralized\tO\ntonic\tO\nclonic\tO\nseizure\tB-Disease\nafter\tO\nstaying\tO\nup\tO\nnearly\tO\nall\tO\nnight\tO\npacking\tO\nand\tO\nmoving\tO\nto\tO\na\tO\nnew\tO\nresidence\tO\n.\tO\n\nThe\tO\npatient\tO\nhad\tO\nno\tO\nother\tO\nrisk\tO\nfactors\tO\nfor\tO\nseizures\tB-Disease\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\nsleep\tB-Disease\ndeprivation\tI-Disease\nmay\tO\nadd\tO\nto\tO\nthe\tO\nrisk\tO\nof\tO\nbupropion\tB-Chemical\n-\tO\nassociated\tO\nseizures\tB-Disease\n.\tO\n\nPostoperative\tB-Disease\nmyalgia\tI-Disease\nafter\tO\nsuccinylcholine\tB-Chemical\n:\tO\nno\tO\nevidence\tO\nfor\tO\nan\tO\ninflammatory\tO\norigin\tO\n.\tO\n\nA\tO\ncommon\tO\nside\tO\neffect\tO\nassociated\tO\nwith\tO\nsuccinylcholine\tB-Chemical\nis\tO\npostoperative\tB-Disease\nmyalgia\tI-Disease\n.\tO\n\nThe\tO\npathogenesis\tO\nof\tO\nthis\tO\nmyalgia\tB-Disease\nis\tO\nstill\tO\nunclear\tO\n;\tO\ninflammation\tB-Disease\nhas\tO\nbeen\tO\nsuggested\tO\nbut\tO\nwithout\tO\nconvincing\tO\nevidence\tO\n.\tO\n\nWe\tO\ndesigned\tO\nthe\tO\npresent\tO\nstudy\tO\nto\tO\ninvestigate\tO\nwhether\tO\nan\tO\ninflammatory\tO\nreaction\tO\ncontributes\tO\nto\tO\nthis\tO\nmyalgia\tB-Disease\n.\tO\n\nThe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nsuccinylcholine\tB-Chemical\n-\tO\nassociated\tO\nmyalgia\tB-Disease\nwas\tO\ndetermined\tO\nin\tO\n64\tO\npatients\tO\npretreated\tO\nwith\tO\nsaline\tO\nor\tO\ndexamethasone\tB-Chemical\nbefore\tO\nsuccinylcholine\tB-Chemical\n(\tO\nn\tO\n=\tO\n32\tO\nfor\tO\neach\tO\n)\tO\n.\tO\n\nIncidence\tO\nand\tO\nseverity\tO\nof\tO\nmyalgia\tB-Disease\ndid\tO\nnot\tO\ndiffer\tO\nsignificantly\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n:\tO\n15\tO\npatients\tO\nin\tO\nthe\tO\ndexamethasone\tB-Chemical\ngroup\tO\ncomplained\tO\nof\tO\nmyalgia\tB-Disease\ncompared\tO\nwith\tO\n18\tO\npatients\tO\nin\tO\nthe\tO\nsaline\tO\ngroup\tO\n,\tO\nand\tO\nsevere\tO\nmyalgia\tB-Disease\nwas\tO\nreported\tO\nby\tO\nfive\tO\npatients\tO\nand\tO\nthree\tO\npatients\tO\n,\tO\nrespectively\tO\n(\tO\nnot\tO\nsignificant\tO\n)\tO\n.\tO\n\nAt\tO\n48\tO\nh\tO\nafter\tO\nsurgery\tO\n,\tO\n12\tO\npatients\tO\nin\tO\nboth\tO\ngroups\tO\nstill\tO\nsuffered\tO\nfrom\tO\nmyalgia\tB-Disease\n(\tO\nnot\tO\nsignificant\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\ninterleukin\tO\n-\tO\n6\tO\n(\tO\nIL\tO\n-\tO\n6\tO\n)\tO\nas\tO\nan\tO\nearly\tO\nmarker\tO\nof\tO\ninflammation\tB-Disease\nwas\tO\nassessed\tO\nin\tO\na\tO\nsubgroup\tO\nof\tO\n10\tO\npatients\tO\npretreated\tO\nwith\tO\nsaline\tO\n.\tO\n\nWe\tO\nfound\tO\nan\tO\nincrease\tO\nof\tO\nIL\tO\n-\tO\n6\tO\nfor\tO\nonly\tO\nthree\tO\npatients\tO\n,\tO\nbut\tO\nonly\tO\none\tO\npatient\tO\nreported\tO\nmyalgia\tB-Disease\n;\tO\nno\tO\nrelationship\tO\nbetween\tO\nmyalgia\tB-Disease\nand\tO\nthe\tO\nincrease\tO\nof\tO\nIL\tO\n-\tO\n6\tO\nwas\tO\nfound\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthere\tO\nis\tO\nno\tO\nevidence\tO\nfor\tO\nan\tO\ninflammatory\tO\norigin\tO\nof\tO\nsuccinylcholine\tB-Chemical\n-\tO\nassociated\tO\nmyalgia\tB-Disease\n.\tO\n\nIMPLICATIONS\tO\n:\tO\nAdministration\tO\nof\tO\ndexamethasone\tB-Chemical\nbefore\tO\nsuccinylcholine\tB-Chemical\nwas\tO\nnot\tO\neffective\tO\nin\tO\ndecreasing\tO\nthe\tO\nincidence\tO\nor\tO\nthe\tO\nseverity\tO\nof\tO\nsuccinylcholine\tB-Chemical\n-\tO\ninduced\tO\npostoperative\tB-Disease\nmyalgia\tI-Disease\n.\tO\n\nFurthermore\tO\n,\tO\nthere\tO\nwas\tO\nno\tO\nsignificant\tO\nrelationship\tO\nbetween\tO\npostoperative\tB-Disease\nmyalgia\tI-Disease\nand\tO\ntime\tO\ncourse\tO\nof\tO\ninterleukin\tO\n-\tO\n6\tO\nconcentrations\tO\n,\tO\na\tO\nmarker\tO\nof\tO\ninflammation\tB-Disease\n.\tO\n\nPretreatment\tO\nwith\tO\ndexamethasone\tB-Chemical\nis\tO\nnot\tO\njustified\tO\nto\tO\nprevent\tO\npostoperative\tB-Disease\nmyalgia\tI-Disease\nafter\tO\nsuccinylcholine\tB-Chemical\n.\tO\n\nEffect\tO\nof\tO\nlindane\tB-Chemical\non\tO\nhepatic\tO\nand\tO\nbrain\tO\ncytochrome\tO\nP450s\tO\nand\tO\ninfluence\tO\nof\tO\nP450\tO\nmodulation\tO\nin\tO\nlindane\tB-Chemical\ninduced\tO\nneurotoxicity\tB-Disease\n.\tO\n\nOral\tO\nadministration\tO\nof\tO\nlindane\tB-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\n,\tO\n5\tO\n,\tO\n10\tO\nand\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nbody\tO\nweight\tO\n)\tO\nfor\tO\n5\tO\ndays\tO\nwas\tO\nfound\tO\nto\tO\nproduce\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nincrease\tO\nin\tO\nthe\tO\nactivity\tO\nof\tO\nP450\tO\ndependent\tO\n7\tO\n-\tO\nethoxyresorufin\tO\n-\tO\nO\tO\n-\tO\ndeethylase\tO\n(\tO\nEROD\tO\n)\tO\n,\tO\n7\tO\n-\tO\npentoxyresorufin\tO\n-\tO\nO\tO\n-\tO\ndealkylase\tO\n(\tO\nPROD\tO\n)\tO\nand\tO\nN\tB-Chemical\n-\tI-Chemical\nnitrosodimethylamine\tI-Chemical\ndemethylase\tO\n(\tO\nNDMA\tB-Chemical\n-\tO\nd\tO\n)\tO\nin\tO\nrat\tO\nbrain\tO\nand\tO\nliver\tO\n.\tO\n\nA\tO\nsignificant\tO\nincrease\tO\nin\tO\nthe\tO\nhepatic\tO\nand\tO\nbrain\tO\nP450\tO\nmonooxygenases\tO\nwas\tO\nalso\tO\nobserved\tO\nwhen\tO\nthe\tO\nduration\tO\nof\tO\nexposure\tO\nof\tO\nlow\tO\ndose\tO\n(\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nof\tO\nlindane\tB-Chemical\nwas\tO\nincreased\tO\nfrom\tO\n5\tO\ndays\tO\nto\tO\n15\tO\nor\tO\n21\tO\ndays\tO\n.\tO\n\nAs\tO\nobserved\tO\nwith\tO\ndifferent\tO\ndoses\tO\n,\tO\nthe\tO\nmagnitude\tO\nof\tO\ninduction\tO\nin\tO\nthe\tO\nactivity\tO\nof\tO\nP450\tO\nmonooxygenases\tO\nwas\tO\nseveral\tO\nfold\tO\nhigher\tO\nin\tO\nliver\tO\nmicrosomes\tO\nwhen\tO\ncompared\tO\nwith\tO\nthe\tO\nbrain\tO\n.\tO\n\nWestern\tO\nblotting\tO\nstudies\tO\nhave\tO\nindicated\tO\nthat\tO\nthe\tO\nincrease\tO\nin\tO\nthe\tO\nP450\tO\nenzymes\tO\ncould\tO\nbe\tO\ndue\tO\nto\tO\nthe\tO\nincrease\tO\nin\tO\nthe\tO\nexpression\tO\nof\tO\nP450\tO\n1A1\tO\n/\tO\n1A2\tO\n,\tO\n2B1\tO\n/\tO\n2B2\tO\nand\tO\n2E1\tO\nisoenzymes\tO\n.\tO\n\nIn\tO\nvitro\tO\nstudies\tO\nusing\tO\norganic\tO\ninhibitors\tO\nspecific\tO\nfor\tO\nindividual\tO\nP450\tO\nisoenzymes\tO\nand\tO\nantibody\tO\ninhibition\tO\nexperiments\tO\nhave\tO\nfurther\tO\ndemonstrated\tO\nthat\tO\nthe\tO\nincrease\tO\nin\tO\nthe\tO\nactivity\tO\nof\tO\nPROD\tO\n,\tO\nEROD\tO\nand\tO\nNDMA\tB-Chemical\n-\tO\nd\tO\nare\tO\ndue\tO\nto\tO\nthe\tO\nincrease\tO\nin\tO\nthe\tO\nlevels\tO\nof\tO\nP450\tO\n2B1\tO\n/\tO\n2B2\tO\n,\tO\n1A1\tO\n/\tO\n1A2\tO\nand\tO\n2E1\tO\nisoenzymes\tO\n,\tO\nrespectively\tO\n.\tO\n\nInduction\tO\nstudies\tO\nhave\tO\nfurther\tO\nshown\tO\nthat\tO\nwhile\tO\npretreatment\tO\nof\tO\n3\tB-Chemical\n-\tI-Chemical\nmethylcholanthrene\tI-Chemical\n(\tO\nMC\tB-Chemical\n)\tO\n,\tO\nan\tO\ninducer\tO\nof\tO\nP4501A1\tO\n/\tO\n1A2\tO\n,\tO\ndid\tO\nnot\tO\nproduce\tO\nany\tO\nsignificant\tO\neffect\tO\nin\tO\nthe\tO\nincidence\tO\nof\tO\nlindane\tB-Chemical\ninduced\tO\nconvulsions\tB-Disease\n,\tO\npretreatment\tO\nwith\tO\nphenobarbital\tB-Chemical\n(\tO\nPB\tO\n)\tO\n,\tO\nan\tO\ninducer\tO\nof\tO\nP450\tO\n2B1\tO\n/\tO\n2B2\tO\nor\tO\nethanol\tB-Chemical\n,\tO\nan\tO\ninducer\tO\nof\tO\nP450\tO\n2E1\tO\ncatalysed\tO\nreactions\tO\n,\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nincidence\tO\nof\tO\nlindane\tB-Chemical\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nSimilarly\tO\n,\tO\nwhen\tO\nthe\tO\nP450\tO\n-\tO\nmediated\tO\nmetabolism\tO\nof\tO\nlindane\tB-Chemical\nwas\tO\nblocked\tO\nby\tO\ncobalt\tB-Chemical\nchloride\tI-Chemical\nincidence\tO\nof\tO\nconvulsions\tB-Disease\nwas\tO\nincreased\tO\nin\tO\nanimals\tO\ntreated\tO\nwith\tO\nlindane\tB-Chemical\nindicating\tO\nthat\tO\nlindane\tB-Chemical\nper\tO\nse\tO\nor\tO\nits\tO\nmetabolites\tO\nformed\tO\nby\tO\nPB\tO\nor\tO\nethanol\tB-Chemical\ninducible\tO\nP450\tO\nisoenzymes\tO\nare\tO\ninvolved\tO\nin\tO\nits\tO\nneurobehavioral\tO\ntoxicity\tB-Disease\n.\tO\n\nAbsolute\tO\nand\tO\nattributable\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\nin\tO\nwomen\tO\non\tO\ncombined\tO\ncyproterone\tB-Chemical\nacetate\tI-Chemical\nand\tO\nethinylestradiol\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nachieve\tO\nabsolute\tO\nrisk\tO\nestimates\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tB-Disease\n)\tO\namong\tO\nwomen\tO\non\tO\ncyproterone\tB-Chemical\nacetate\tI-Chemical\nplus\tO\nethinylestradiol\tB-Chemical\n(\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\n)\tO\n,\tO\nand\tO\namong\tO\nwomen\tO\non\tO\ncombined\tB-Chemical\noral\tI-Chemical\ncontraceptives\tI-Chemical\n(\tO\nCOCs\tB-Chemical\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nFrom\tO\nthe\tO\nDanish\tO\nNational\tO\nRegister\tO\nof\tO\nPatients\tO\n(\tO\nNRP\tO\n)\tO\n,\tO\n1996\tO\nto\tO\n1998\tO\n,\tO\nthe\tO\nrecords\tO\nof\tO\n1\tO\n.\tO\n1\tO\nmillion\tO\nDanish\tO\nwomen\tO\n,\tO\nages\tO\n15\tO\nto\tO\n44\tO\nyears\tO\n,\tO\nwere\tO\nsearched\tO\nfor\tO\nevidence\tO\nof\tO\nVTE\tB-Disease\n.\tO\n\nCOC\tB-Chemical\nuse\tO\nwas\tO\nascertained\tO\nthrough\tO\nmailed\tO\nquestionnaires\tO\n.\tO\n\nSales\tO\nstatistics\tO\nof\tO\nCOCs\tB-Chemical\nand\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\nwere\tO\nprovided\tO\nthrough\tO\nDanish\tO\nDrug\tO\nStatistics\tO\n.\tO\n\nRESULTS\tO\n:\tO\nDuring\tO\nthe\tO\ntime\tO\nframe\tO\nof\tO\nthe\tO\nstudy\tO\n,\tO\n330\tO\nwomen\tO\nwere\tO\nfound\tO\nto\tO\nhave\tO\nhad\tO\nVTE\tB-Disease\nwhile\tO\non\tO\nCOCs\tB-Chemical\n.\tO\n\nOf\tO\nthese\tO\nwomen\tO\n,\tO\n67\tO\nwere\tO\non\tO\nlevonorgestrel\tB-Chemical\n-\tO\ncontaining\tO\nCOCs\tB-Chemical\n.\tO\n\nEleven\tO\nwere\tO\non\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\n.\tO\n\nThe\tO\ncorresponding\tO\nabsolute\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nwas\tO\n3\tO\n.\tO\n4\tO\n(\tO\nrange\tO\n,\tO\n3\tO\n.\tO\n1\tO\n-\tO\n3\tO\n.\tO\n8\tO\n)\tO\nper\tO\n10\tO\n000\tO\nwomen\tO\nyears\tO\namong\tO\nthe\tO\nwomen\tO\non\tO\nCOCs\tB-Chemical\n,\tO\n4\tO\n.\tO\n2\tO\n(\tO\nrange\tO\n,\tO\n3\tO\n.\tO\n2\tO\n-\tO\n5\tO\n.\tO\n2\tO\n)\tO\nper\tO\n10\tO\n000\tO\nwomen\tO\nyears\tO\namong\tO\nwomen\tO\non\tO\nlevonorgestrel\tB-Chemical\n-\tO\ncontaining\tO\nCOCs\tB-Chemical\n,\tO\nand\tO\n3\tO\n.\tO\n1\tO\n(\tO\nrange\tO\n,\tO\n1\tO\n.\tO\n3\tO\n-\tO\n4\tO\n.\tO\n9\tO\n)\tO\nper\tO\n10\tO\n000\tO\nwomen\tO\nyears\tO\namong\tO\nthe\tO\nwomen\tO\non\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\nresults\tO\nsuggest\tO\nthe\tO\nabsolute\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\namong\tO\nDanish\tO\nwomen\tO\non\tO\nCOCs\tB-Chemical\nis\tO\nsimilar\tO\nto\tO\nthat\tO\namong\tO\nwomen\tO\ntaking\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\n.\tO\n\nComparison\tO\nof\tO\ndevelopmental\tO\ntoxicology\tO\nof\tO\naspirin\tB-Chemical\n(\tO\nacetylsalicylic\tB-Chemical\nacid\tI-Chemical\n)\tO\nin\tO\nrats\tO\nusing\tO\nselected\tO\ndosing\tO\nparadigms\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAnalysis\tO\nof\tO\nthe\tO\nliterature\tO\nfor\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\n(\tO\nNSAIDs\tO\n)\tO\nsuggests\tO\nthat\tO\na\tO\nlow\tO\nincidence\tO\nof\tO\ndevelopmental\tB-Disease\nanomalies\tI-Disease\noccurs\tO\nin\tO\nrats\tO\ngiven\tO\nNSAIDs\tO\non\tO\nspecific\tO\ndays\tO\nduring\tO\norganogenesis\tO\n.\tO\n\nAspirin\tB-Chemical\n(\tO\nacetylsalicylic\tB-Chemical\nacid\tI-Chemical\n[\tO\nASA\tB-Chemical\n]\tO\n)\tO\n,\tO\nan\tO\nirreversible\tO\ncyclooxygenase\tO\n1\tO\nand\tO\n2\tO\ninhibitor\tO\n,\tO\ninduces\tO\ndevelopmental\tB-Disease\nanomalies\tI-Disease\nwhen\tO\nadministered\tO\nto\tO\nWistar\tO\nrats\tO\non\tO\ngestational\tO\nday\tO\n(\tO\nGD\tO\n)\tO\n9\tO\n,\tO\n10\tO\n,\tO\nor\tO\n11\tO\n(\tO\nKimmel\tO\nCA\tO\n,\tO\nWilson\tO\nJG\tO\n,\tO\nSchumacher\tO\nHJ\tO\n.\tO\nTeratology\tO\n4\tO\n:\tO\n15\tO\n-\tO\n24\tO\n,\tO\n1971\tO\n)\tO\n.\tO\n\nThere\tO\nare\tO\nno\tO\npublished\tO\nASA\tB-Chemical\nstudies\tO\nusing\tO\nthe\tO\nmultiple\tO\ndosing\tO\nparadigm\tO\nof\tO\nGDs\tO\n6\tO\nto\tO\n17\tO\n.\tO\n\nObjectives\tO\nof\tO\nthe\tO\ncurrent\tO\nstudy\tO\nwere\tO\nto\tO\ncompare\tO\nresults\tO\nbetween\tO\nSprague\tO\n-\tO\nDawley\tO\n(\tO\nSD\tO\n)\tO\nand\tO\nWistar\tO\nstrains\tO\nwhen\tO\nASA\tB-Chemical\nis\tO\nadministered\tO\non\tO\nGD\tO\n9\tO\n,\tO\n10\tO\n,\tO\nor\tO\n11\tO\n;\tO\nto\tO\ncompare\tO\nthe\tO\nmalformation\tO\npatterns\tO\nfollowing\tO\nsingle\tO\nand\tO\nmultiple\tO\ndosings\tO\nduring\tO\norganogenesis\tO\nin\tO\nSD\tO\nrats\tO\n;\tO\nand\tO\nto\tO\ntest\tO\nthe\tO\nhypothesis\tO\nthat\tO\nmaternal\tO\ngastrointestinal\tB-Disease\ntoxicity\tI-Disease\nconfounds\tO\nthe\tO\ndetection\tO\nof\tO\nlow\tO\nincidence\tO\nmalformations\tB-Disease\nwith\tO\nASA\tB-Chemical\nwhen\tO\na\tO\nmultiple\tO\ndosing\tO\nparadigm\tO\nis\tO\nused\tO\n.\tO\n\nMETHODS\tO\n:\tO\nASA\tB-Chemical\nwas\tO\nadministered\tO\nas\tO\na\tO\nsingle\tO\ndose\tO\non\tO\nGD\tO\n9\tO\n(\tO\n0\tO\n,\tO\n250\tO\n,\tO\n500\tO\n,\tO\nor\tO\n625\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\n10\tO\n(\tO\n0\tO\n,\tO\n500\tO\n,\tO\n625\tO\n,\tO\nor\tO\n750\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nor\tO\n11\tO\n(\tO\n0\tO\n,\tO\n500\tO\n,\tO\n750\tO\n,\tO\nor\tO\n1000\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\nfrom\tO\nGD\tO\n6\tO\nto\tO\nGD\tO\n17\tO\n(\tO\n0\tO\n,\tO\n50\tO\n,\tO\n125\tO\n,\tO\nor\tO\n250\tO\nmg\tO\n/\tO\nkg\tO\na\tO\nday\tO\n)\tO\nin\tO\nthe\tO\nmultiple\tO\ndose\tO\nstudy\tO\nto\tO\nSD\tO\nrats\tO\n.\tO\n\nAnimals\tO\nwere\tO\nkilled\tO\non\tO\nGD\tO\n21\tO\n,\tO\nand\tO\nfetuses\tO\nwere\tO\nexamined\tO\nviscerally\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nliterature\tO\nevaluation\tO\nsuggested\tO\nthat\tO\nNSAIDs\tO\ninduce\tO\nventricular\tB-Disease\nseptal\tI-Disease\ndefects\tI-Disease\n(\tO\nVSDs\tB-Disease\n)\tO\nand\tO\nmidline\tB-Disease\ndefects\tI-Disease\n(\tO\nMDs\tB-Disease\n)\tO\nin\tO\nrats\tO\nand\tO\ndiaphragmatic\tB-Disease\nhernia\tI-Disease\n(\tO\nDH\tB-Disease\n)\tO\n,\tO\nMDs\tB-Disease\n,\tO\nand\tO\nVSDs\tB-Disease\nin\tO\nrabbits\tO\n(\tO\nCook\tO\nJC\tO\net\tO\nal\tO\n.\tO\n,\tO\n2003\tO\n)\tO\n;\tO\nhence\tO\n,\tO\nthe\tO\npresent\tO\nstudy\tO\nfocused\tO\non\tO\nthese\tO\nmalformations\tB-Disease\n,\tO\neven\tO\nthough\tO\nASA\tB-Chemical\ninduces\tO\nseveral\tO\nother\tO\nlow\tO\n-\tO\nincidence\tO\nmalformations\tB-Disease\n.\tO\n\nIn\tO\nsingle\tO\ndose\tO\nstudies\tO\n,\tO\nDH\tB-Disease\n,\tO\nMD\tB-Disease\n,\tO\nand\tO\nVSD\tB-Disease\nwere\tO\ninduced\tO\non\tO\nGDs\tO\n9\tO\nand\tO\n10\tO\n.\tO\n\nVSD\tB-Disease\nalso\tO\nwas\tO\nnoted\tO\nfollowing\tO\ntreatment\tO\non\tO\nGD\tO\n11\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nDH\tB-Disease\nand\tO\nMD\tB-Disease\nwere\tO\nnoted\tO\nin\tO\nthe\tO\nmultiple\tO\ndose\tO\nstudy\tO\ndesign\tO\nonly\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\n,\tO\nand\tO\nVSD\tB-Disease\nwas\tO\nnoted\tO\nacross\tO\nall\tO\ndose\tO\ngroups\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nHigh\tO\nconcordance\tO\nin\tO\nmajor\tO\ndevelopmental\tB-Disease\nanomalies\tI-Disease\nbetween\tO\nWistar\tO\nand\tO\nSD\tO\nrats\tO\nwere\tO\nnoted\tO\nwith\tO\nthe\tO\nexception\tO\nof\tO\nVSD\tB-Disease\nin\tO\nthe\tO\nSD\tO\nrats\tO\nand\tO\nhydrocephalus\tB-Disease\nin\tO\nthe\tO\nWistar\tO\nrats\tO\n.\tO\n\nVariations\tO\nand\tO\nmalformations\tB-Disease\nwere\tO\nsimilar\tO\nwhen\tO\nASA\tB-Chemical\nwas\tO\nadministered\tO\nas\tO\na\tO\nsingle\tO\ndose\tO\nor\tO\nduring\tO\nthe\tO\nperiod\tO\nof\tO\norganogenesis\tO\n(\tO\nGDs\tO\n6\tO\nto\tO\n17\tO\n)\tO\n.\tO\n\nIt\tO\nwas\tO\nalso\tO\nevident\tO\nthat\tO\n,\tO\nby\tO\ntitrating\tO\nthe\tO\ndose\tO\nto\tO\nachieve\tO\na\tO\nmaximum\tO\ntolerated\tO\ndose\tO\n,\tO\nmalformations\tB-Disease\nthat\tO\nnormally\tO\noccur\tO\nat\tO\nlow\tO\nincidence\tO\n,\tO\nas\tO\nreported\tO\nfrom\tO\nprevious\tO\nsingle\tO\ndose\tO\nstudies\tO\n,\tO\ncould\tO\nalso\tO\nbe\tO\ninduced\tO\nwith\tO\nASA\tB-Chemical\ngiven\tO\nat\tO\nmultiple\tO\ndoses\tO\n.\tO\n\nReversal\tO\nof\tO\ncentral\tO\nbenzodiazepine\tB-Chemical\neffects\tO\nby\tO\nflumazenil\tB-Chemical\nafter\tO\nintravenous\tO\nconscious\tO\nsedation\tO\nwith\tO\ndiazepam\tB-Chemical\nand\tO\nopioids\tO\n:\tO\nreport\tO\nof\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\nmulticenter\tO\nstudy\tO\n.\tO\n\nThe\tO\nFlumazenil\tB-Chemical\nin\tO\nIntravenous\tO\nConscious\tO\nSedation\tO\nwith\tO\nDiazepam\tB-Chemical\nMulticenter\tO\nStudy\tO\nGroup\tO\nII\tO\n.\tO\n\nThe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\na\tO\nnew\tO\nbenzodiazepine\tB-Chemical\nantagonist\tO\n,\tO\nflumazenil\tB-Chemical\n,\tO\nwere\tO\nassessed\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\nmulticenter\tO\nstudy\tO\n.\tO\n\nFlumazenil\tB-Chemical\n(\tO\nmean\tO\ndose\tO\n,\tO\n0\tO\n.\tO\n76\tO\nmg\tO\n)\tO\nor\tO\nplacebo\tO\n(\tO\nmean\tO\ndose\tO\n,\tO\n8\tO\n.\tO\n9\tO\nml\tO\n)\tO\nwas\tO\nadministered\tO\nintravenously\tO\nto\tO\n130\tO\nand\tO\n67\tO\npatients\tO\n,\tO\nrespectively\tO\n,\tO\nwho\tO\nhad\tO\nbeen\tO\ngiven\tO\ndiazepam\tB-Chemical\nin\tO\nconjunction\tO\nwith\tO\nan\tO\nopioid\tO\n(\tO\nfentanyl\tB-Chemical\n,\tO\nmeperidine\tB-Chemical\n,\tO\nor\tO\nmorphine\tB-Chemical\n)\tO\nfor\tO\nthe\tO\ninduction\tO\nand\tO\nmaintenance\tO\nof\tO\nintravenous\tO\nconscious\tO\nsedation\tO\nfor\tO\ndiagnostic\tO\nor\tO\ntherapeutic\tO\nsurgical\tO\nprocedures\tO\n.\tO\n\nThe\tO\ngroup\tO\nassessable\tO\nfor\tO\nefficacy\tO\ncomprised\tO\n122\tO\npatients\tO\ntreated\tO\nwith\tO\nflumazenil\tB-Chemical\nand\tO\n64\tO\npatients\tO\ngiven\tO\nplacebo\tO\n.\tO\n\nAfter\tO\n5\tO\nminutes\tO\n,\tO\n80\tO\n/\tO\n115\tO\n(\tO\n70\tO\n%\tO\n)\tO\nflumazenil\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\n,\tO\ncompared\tO\nwith\tO\n21\tO\n/\tO\n63\tO\n(\tO\n33\tO\n%\tO\n)\tO\nplacebo\tO\n-\tO\ntreated\tO\npatients\tO\n,\tO\nwere\tO\ncompletely\tO\nawake\tO\nand\tO\nalert\tO\n,\tO\nas\tO\nindicated\tO\nby\tO\na\tO\nscore\tO\nof\tO\n5\tO\non\tO\nthe\tO\nObserver\tO\n'\tO\ns\tO\nAssessment\tO\nof\tO\nAlertness\tO\n/\tO\nSedation\tO\nScale\tO\n.\tO\n\nNinety\tO\n-\tO\nfive\tO\npercent\tO\nof\tO\npatients\tO\nin\tO\neach\tO\ngroup\tO\nwho\tO\nattained\tO\na\tO\nscore\tO\nof\tO\n5\tO\nat\tO\nthe\tO\n5\tO\n-\tO\nminute\tO\nassessment\tO\nshowed\tO\nno\tO\nloss\tO\nof\tO\nalertness\tO\nthroughout\tO\nthe\tO\n180\tO\n-\tO\nminute\tO\nassessment\tO\nperiod\tO\n.\tO\n\nFlumazenil\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nalso\tO\nperformed\tO\nsignificantly\tO\nbetter\tO\non\tO\nthe\tO\nFinger\tO\n-\tO\nto\tO\n-\tO\nNose\tO\nTest\tO\nand\tO\nthe\tO\nrecall\tO\nof\tO\npictures\tO\nshown\tO\nat\tO\nthe\tO\n5\tO\n-\tO\nminute\tO\nassessment\tO\n.\tO\n\nFlumazenil\tB-Chemical\nwas\tO\nwell\tO\ntolerated\tO\n,\tO\nwith\tO\nno\tO\nserious\tO\nadverse\tO\neffects\tO\nreported\tO\n.\tO\n\nThirty\tO\n-\tO\nnine\tO\n(\tO\n30\tO\n%\tO\n)\tO\nof\tO\nflumazenil\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\n,\tO\ncompared\tO\nwith\tO\n17\tO\n(\tO\n25\tO\n%\tO\n)\tO\nof\tO\nplacebo\tO\n-\tO\ntreated\tO\npatients\tO\nhad\tO\none\tO\nor\tO\nmore\tO\ndrug\tO\n-\tO\nrelated\tO\nadverse\tO\nexperiences\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tO\neffects\tO\nwere\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\nin\tO\nthe\tO\nflumazenil\tB-Chemical\ngroup\tO\nand\tO\nnausea\tB-Disease\nand\tO\ninjection\tO\n-\tO\nsite\tO\npain\tB-Disease\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\n.\tO\n\nFlumazenil\tB-Chemical\nwas\tO\nfound\tO\nto\tO\npromptly\tO\nreverse\tO\nsedation\tO\ninduced\tO\nby\tO\ndiazepam\tB-Chemical\nin\tO\nthe\tO\npresence\tO\nof\tO\nopioids\tO\n.\tO\n\nMethylphenidate\tB-Chemical\n-\tO\ninduced\tO\nobsessive\tB-Disease\n-\tI-Disease\ncompulsive\tI-Disease\nsymptoms\tI-Disease\nin\tO\nan\tO\nelderly\tO\nman\tO\n.\tO\n\nAn\tO\n82\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\ntreatment\tB-Disease\n-\tI-Disease\nresistant\tI-Disease\ndepression\tI-Disease\nand\tO\nearly\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nwas\tO\nstarted\tO\non\tO\nmethylphenidate\tB-Chemical\n.\tO\n\nSignificant\tO\nobsessive\tB-Disease\n-\tI-Disease\ncompulsive\tI-Disease\nbehavior\tI-Disease\nensued\tO\nbut\tO\ndiminished\tO\nover\tO\nseveral\tO\nweeks\tO\nwhen\tO\nmethylphenidate\tB-Chemical\nwas\tO\nreplaced\tO\nby\tO\nfluvoxamine\tB-Chemical\n.\tO\n\nThe\tO\npatient\tO\nhad\tO\nno\tO\nprior\tO\npsychiatric\tB-Disease\nhistory\tO\n,\tO\nbut\tO\nhe\tO\nhad\tO\na\tO\nsister\tO\nwith\tO\nobsessive\tB-Disease\n-\tI-Disease\ncompulsive\tI-Disease\ndisorder\tI-Disease\n.\tO\n\nIt\tO\nappears\tO\nthat\tO\nmethylphenidate\tB-Chemical\nprecipitated\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\npathological\tO\nbehavior\tO\n.\tO\n\nCiprofloxacin\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nand\tO\nautoimmune\tB-Disease\nhemolytic\tI-Disease\nanemia\tI-Disease\n.\tO\n\nCiprofloxacin\tB-Chemical\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nseveral\tO\nside\tO\neffects\tO\nincluding\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nand\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nThe\tO\ncombination\tO\nof\tO\nboth\tO\nside\tO\neffects\tO\nis\tO\nextremely\tO\nrare\tO\n.\tO\n\nIn\tO\nthis\tO\nreport\tO\n,\tO\nwe\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\nciprofloxacin\tB-Chemical\n-\tO\ninduced\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nand\tO\nautoimmune\tB-Disease\nhemolytic\tI-Disease\nanemia\tI-Disease\n.\tO\n\nHemolytic\tB-Disease\nanemia\tI-Disease\nimproved\tO\nafter\tO\nstopping\tO\nthe\tO\ndrug\tO\nand\tO\ninitiation\tO\nof\tO\nsteroid\tB-Chemical\ntherapy\tO\n.\tO\n\nUnfortunately\tO\n,\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nwas\tO\nirreversible\tO\nand\tO\nthe\tO\npatient\tO\ndeveloped\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n.\tO\n\nPotential\tO\ndeleterious\tO\neffect\tO\nof\tO\nfurosemide\tB-Chemical\nin\tO\nradiocontrast\tO\nnephropathy\tB-Disease\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\nefficacy\tO\nof\tO\nfurosemide\tB-Chemical\nin\tO\naddition\tO\nto\tO\nintravenous\tO\nfluids\tO\nin\tO\nthe\tO\nprevention\tO\nof\tO\nradiocontrast\tO\nnephropathy\tB-Disease\n.\tO\n\n18\tO\npatients\tO\n,\tO\nreferred\tO\nto\tO\na\tO\nradiocontrast\tO\nstudy\tO\n,\tO\nconsidered\tO\nat\tO\nrisk\tO\nbecause\tO\nof\tO\npreexisting\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\n,\tO\nwere\tO\nenrolled\tO\nin\tO\na\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ncontrolled\tO\ntrial\tO\n,\tO\nperformed\tO\nat\tO\nthe\tO\nsecondary\tO\ncare\tO\ncenter\tO\nof\tO\na\tO\n1\tO\n,\tO\n100\tO\n-\tO\nbed\tO\nprivate\tO\nuniversity\tO\nhospital\tO\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nfluids\tO\n,\tO\nthe\tO\ntreatment\tO\ngroup\tO\nreceived\tO\nfurosemide\tB-Chemical\n(\tO\nmean\tO\ndose\tO\n110\tO\nmg\tO\n)\tO\nintravenously\tO\n30\tO\nmin\tO\nprior\tO\nto\tO\nthe\tO\ninjection\tO\nof\tO\ncontrast\tO\nmaterial\tO\n.\tO\n\nThe\tO\ncontrol\tO\ngroup\tO\nreceived\tO\nfluids\tO\n(\tO\nmean\tO\n3\tO\nliters\tO\n)\tO\n.\tO\n\nRadiological\tO\nstudies\tO\nwere\tO\nmostly\tO\nangiographies\tO\nperformed\tO\nwith\tO\nboth\tO\nionic\tO\nand\tO\nnon\tO\n-\tO\nionic\tO\ncontrast\tO\nmaterial\tO\n,\tO\nat\tO\nan\tO\naverage\tO\ndose\tO\nof\tO\n245\tO\nml\tO\n.\tO\n\nRenal\tB-Disease\nfunction\tI-Disease\nsignificantly\tI-Disease\ndeteriorated\tI-Disease\nin\tO\nthe\tO\ngroup\tO\npretreated\tO\nwith\tO\nfurosemide\tB-Chemical\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n005\tO\nby\tO\nANOVA\tO\n)\tO\n,\tO\nwith\tO\na\tO\nrise\tO\nin\tO\nserum\tO\ncreatinine\tB-Chemical\nfrom\tO\n145\tO\n+\tO\n/\tO\n-\tO\n13\tO\nto\tO\n182\tO\n+\tO\n/\tO\n-\tO\n16\tO\nmumol\tO\n/\tO\nl\tO\nat\tO\n24\tO\nh\tO\n,\tO\nwhile\tO\nno\tO\nchange\tO\noccurred\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\nfrom\tO\n141\tO\n+\tO\n/\tO\n-\tO\n6\tO\nto\tO\n142\tO\n+\tO\n/\tO\n-\tO\n7\tO\nmumol\tO\n/\tO\nl\tO\n)\tO\n.\tO\n\nRenal\tB-Disease\nfailure\tI-Disease\nwas\tO\nassociated\tO\nwith\tO\nweight\tB-Disease\nloss\tI-Disease\nin\tO\nthe\tO\nfurosemide\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\n.\tO\n\nFurosemide\tB-Chemical\nmay\tO\nbe\tO\ndeleterious\tO\nin\tO\nthe\tO\nprevention\tO\nof\tO\nradiocontrast\tO\nnephropathy\tB-Disease\n.\tO\n\nProgestational\tO\nagents\tO\nand\tO\nblood\tB-Disease\ncoagulation\tI-Disease\n.\tO\n\nVII\tO\n.\tO\n\nThromboembolic\tB-Disease\nand\tO\nother\tO\ncomplications\tO\nof\tO\noral\tB-Chemical\ncontraceptive\tI-Chemical\ntherapy\tO\nin\tO\nrelationship\tO\nto\tO\npretreatment\tO\nlevels\tO\nof\tO\nblood\tB-Disease\ncoagulation\tI-Disease\nfactors\tO\n:\tO\nsummary\tO\nreport\tO\nof\tO\na\tO\nten\tO\n-\tO\nyear\tO\nstudy\tO\n.\tO\n\nDuring\tO\na\tO\nten\tO\n-\tO\nyear\tO\nperiod\tO\n,\tO\n348\tO\nwomen\tO\nwere\tO\nstudied\tO\nfor\tO\na\tO\ntotal\tO\nof\tO\n5\tO\n,\tO\n877\tO\npatient\tO\nmonths\tO\nin\tO\nfour\tO\nseparate\tO\nstudies\tO\nrelating\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nto\tO\nchanges\tO\nin\tO\nhematologic\tO\nparameters\tO\n.\tO\n\nSignificant\tO\nincreases\tO\nin\tO\ncertain\tO\nfactors\tO\nof\tO\nthe\tO\nblood\tB-Disease\ncoagulation\tI-Disease\nand\tO\nfibrinolysin\tO\nsystems\tO\n(\tO\nfactors\tO\nI\tO\n,\tO\nII\tO\n,\tO\nVII\tO\n,\tO\nVIII\tO\n,\tO\nIX\tO\n,\tO\nand\tO\nX\tO\nand\tO\nplasminogen\tO\n)\tO\nwere\tO\nobserved\tO\nin\tO\nthe\tO\ntreated\tO\ngroups\tO\n.\tO\n\nSevere\tO\ncomplications\tO\ndeveloped\tO\nin\tO\nfour\tO\npatients\tO\n.\tO\n\nAll\tO\nfour\tO\nhad\tO\nan\tO\nabnormal\tO\nblood\tB-Disease\ncoagulation\tI-Disease\nprofile\tO\n,\tO\nsuggesting\tO\n\"\tO\nhypercoagulability\tB-Disease\n\"\tO\nbefore\tO\ninitiation\tO\nof\tO\ntherapy\tO\n.\tO\n\nSome\tO\nof\tO\nthese\tO\nfindings\tO\nrepresented\tO\nthe\tO\nmost\tO\nextreme\tO\nabnormalities\tO\nseen\tO\nin\tO\nthe\tO\nentire\tO\ngroup\tO\nof\tO\npatients\tO\n;\tO\nsome\tO\nincreased\tO\nfurther\tO\nduring\tO\ntherapy\tO\n.\tO\n\nOne\tO\nof\tO\nthese\tO\npatients\tO\ndeveloped\tO\na\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nbefore\tO\nreceiving\tO\nany\tO\nmedication\tO\n,\tO\nshortly\tO\nafter\tO\nthe\tO\nbase\tO\n-\tO\nline\tO\nvalues\tO\nwere\tO\nobtained\tO\n.\tO\n\nOne\tO\npatient\tO\ndeveloped\tO\nretinopathy\tB-Disease\n19\tO\nmonths\tO\nafter\tO\nshe\tO\nbegan\tO\ntherapy\tO\n,\tO\nand\tO\nanother\tO\ndeveloped\tO\nthrombophlebitis\tB-Disease\nafter\tO\n27\tO\nmonths\tO\nof\tO\ntherapy\tO\n.\tO\n\nThe\tO\nfourth\tO\npatient\tO\ndeveloped\tO\nthrombophlebitis\tB-Disease\n14\tO\ndays\tO\nafter\tO\ninitiation\tO\nof\tO\ncontraceptive\tO\ntherapy\tO\n.\tO\n\nAll\tO\nfour\tO\npatients\tO\nwere\tO\nof\tO\nthe\tO\nA\tO\nor\tO\nAB\tO\nblood\tO\ngroup\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nsuggested\tO\nthe\tO\npossiblility\tO\nof\tO\nincreased\tO\npropensity\tO\nfor\tO\nthromboembolic\tB-Disease\nepisodes\tI-Disease\nin\tO\npatients\tO\npossessing\tO\nthe\tO\nA\tO\nantigen\tO\n.\tO\n\nIt\tO\nappears\tO\nfrom\tO\nthese\tO\ndata\tO\nthat\tO\nhematologic\tO\nwork\tO\n-\tO\nups\tO\nmay\tO\nbe\tO\nuseful\tO\nin\tO\nwomen\tO\nwho\tO\nare\tO\nabout\tO\nto\tO\nstart\tO\nlong\tO\n-\tO\nterm\tO\noral\tB-Chemical\ncontraceptive\tI-Chemical\ntherapy\tO\n.\tO\n\nOrthostatic\tB-Disease\nhypotension\tI-Disease\noccurs\tO\nfollowing\tO\nalpha\tO\n2\tO\n-\tO\nadrenoceptor\tO\nblockade\tO\nin\tO\nchronic\tO\nprazosin\tB-Chemical\n-\tO\npretreated\tO\nconscious\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n.\tO\n\n1\tO\n.\tO\n\nStudies\tO\nwere\tO\nperformed\tO\nto\tO\nevaluate\tO\nwhether\tO\nchronic\tO\nprazosin\tB-Chemical\ntreatment\tO\nalters\tO\nthe\tO\nalpha\tO\n2\tO\n-\tO\nadrenoceptor\tO\nfunction\tO\nfor\tO\northostatic\tO\ncontrol\tO\nof\tO\narterial\tO\nblood\tO\npressure\tO\nin\tO\nconscious\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n(\tO\nSHR\tO\n)\tO\n.\tO\n\n2\tO\n.\tO\n\nConscious\tO\nSHR\tO\n(\tO\nmale\tO\n300\tO\n-\tO\n350\tO\ng\tO\n)\tO\nwere\tO\nsubjected\tO\nto\tO\n90\tO\ndegrees\tO\nhead\tO\n-\tO\nup\tO\ntilts\tO\nfor\tO\n60\tO\ns\tO\nfollowing\tO\nacute\tO\nadministration\tO\nof\tO\nprazosin\tB-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nor\tO\nrauwolscine\tB-Chemical\n(\tO\n3\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\n.\tO\n\nOrthostatic\tB-Disease\nhypotension\tI-Disease\nwas\tO\ndetermined\tO\nby\tO\nthe\tO\naverage\tO\ndecrease\tO\n(\tO\n%\tO\n)\tO\nin\tO\nmean\tO\narterial\tO\npressure\tO\n(\tO\nMAP\tO\nfemoral\tO\n)\tO\nover\tO\nthe\tO\n60\tO\n-\tO\ns\tO\ntilt\tO\nperiod\tO\n.\tO\n\nThe\tO\nbasal\tO\nMAP\tO\nof\tO\nconscious\tO\nSHR\tO\nwas\tO\nreduced\tO\nto\tO\na\tO\nsimilar\tO\nextent\tO\nby\tO\nprazosin\tB-Chemical\n(\tO\n-\tO\n23\tO\n%\tO\n(\tO\n-\tO\n)\tO\n-\tO\n26\tO\n%\tO\nMAP\tO\n)\tO\nand\tO\nrauwolscine\tB-Chemical\n(\tO\n-\tO\n16\tO\n%\tO\n(\tO\n-\tO\n)\tO\n-\tO\n33\tO\n%\tO\nMAP\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nhead\tO\n-\tO\nup\tO\ntilt\tO\ninduced\tO\northostatic\tB-Disease\nhypotension\tI-Disease\nin\tO\nthe\tO\nSHR\tO\ntreated\tO\nwith\tO\nprazosin\tB-Chemical\n(\tO\n-\tO\n16\tO\n%\tO\nMAP\tO\n,\tO\nn\tO\n=\tO\n6\tO\n)\tO\n,\tO\nbut\tO\nnot\tO\nin\tO\nthe\tO\nSHR\tO\ntreated\tO\nwith\tO\nrauwolscine\tB-Chemical\n(\tO\nless\tO\nthan\tO\n+\tO\n2\tO\n%\tO\nMAP\tO\n,\tO\nn\tO\n=\tO\n6\tO\n)\tO\n.\tO\n\n3\tO\n.\tO\n\nConscious\tO\nSHR\tO\nwere\tO\ntreated\tO\nfor\tO\n4\tO\ndays\tO\nwith\tO\nprazosin\tB-Chemical\nat\tO\n2\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nday\tO\n-\tO\n1\tO\ni\tO\n.\tO\np\tO\n.\tO\nfor\tO\nchronic\tO\nalpha\tO\n1\tO\n-\tO\nadrenoceptor\tO\nblockade\tO\n.\tO\n\nMAP\tO\nin\tO\nconscious\tO\nSHR\tO\nafter\tO\nchronic\tO\nprazosin\tB-Chemical\ntreatment\tO\nwas\tO\n14\tO\n%\tO\nlower\tO\nthan\tO\nin\tO\nthe\tO\nuntreated\tO\nSHR\tO\n(\tO\nn\tO\n=\tO\n8\tO\n)\tO\n.\tO\n\nHead\tO\n-\tO\nup\tO\ntilts\tO\nin\tO\nthese\tO\nrats\tO\ndid\tO\nnot\tO\nproduce\tO\northostatic\tB-Disease\nhypotension\tI-Disease\nwhen\tO\nperformed\tO\neither\tO\nprior\tO\nto\tO\nor\tO\nafter\tO\nacute\tO\ndosing\tO\nof\tO\nprazosin\tB-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nConversely\tO\n,\tO\nadministration\tO\nof\tO\nrauwolscine\tB-Chemical\n(\tO\n3\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nin\tO\nchronic\tO\nprazosin\tB-Chemical\ntreated\tO\nSHR\tO\ndecreased\tO\nthe\tO\nbasal\tO\nMAP\tO\nby\tO\n12\tO\n-\tO\n31\tO\n%\tO\n(\tO\nn\tO\n=\tO\n4\tO\n)\tO\n,\tO\nand\tO\nsubsequent\tO\ntilts\tO\ninduced\tO\nfurther\tO\ndrops\tO\nof\tO\nMAP\tO\nby\tO\n19\tO\n-\tO\n23\tO\n%\tO\nin\tO\nthese\tO\nrats\tO\n.\tO\n\n4\tO\n.\tO\n\nThe\tO\npressor\tO\nresponses\tO\nand\tO\nbradycardia\tB-Disease\nto\tO\nthe\tO\nalpha\tO\n1\tO\n-\tO\nagonist\tO\ncirazoline\tB-Chemical\n(\tO\n0\tO\n.\tO\n6\tO\nand\tO\n2\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\n,\tO\nthe\tO\nalpha\tO\n2\tO\n-\tO\nagonist\tO\nAbbott\tB-Chemical\n-\tI-Chemical\n53693\tI-Chemical\n(\tO\n1\tO\nand\tO\n3\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\n,\tO\nand\tO\nnoradrenaline\tB-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nand\tO\n1\tO\n.\tO\n0\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nwere\tO\ndetermined\tO\nin\tO\nconscious\tO\nSHR\tO\nwith\tO\nand\tO\nwithout\tO\nchronic\tO\nprazosin\tB-Chemical\npretreatment\tO\n.\tO\n\nBoth\tO\nthe\tO\npressor\tO\nand\tO\nbradycardia\tB-Disease\neffects\tO\nof\tO\ncirazoline\tB-Chemical\nwere\tO\nabolished\tO\nin\tO\nchronic\tO\nprazosin\tB-Chemical\ntreated\tO\nSHR\tO\n(\tO\nn\tO\n=\tO\n4\tO\n)\tO\nas\tO\ncompared\tO\nto\tO\nthe\tO\nuntreated\tO\nSHR\tO\n(\tO\nn\tO\n=\tO\n4\tO\n)\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nthe\tO\npressor\tO\neffects\tO\nof\tO\nAbbott\tB-Chemical\n-\tI-Chemical\n53693\tI-Chemical\nwere\tO\nsimilar\tO\nin\tO\nboth\tO\ngroups\tO\nof\tO\nSHR\tO\n,\tO\nbut\tO\nthe\tO\naccompanying\tO\nbradycardia\tB-Disease\nwas\tO\ngreater\tO\nin\tO\nSHR\tO\nwith\tO\nchronic\tO\nprazosin\tB-Chemical\ntreatment\tO\nthan\tO\nwithout\tO\nsuch\tO\ntreatment\tO\n.\tO\n\nFurthermore\tO\n,\tO\nthe\tO\nbradycardia\tB-Disease\nthat\tO\naccompanied\tO\nthe\tO\nnoradrenaline\tB-Chemical\n-\tO\ninduced\tO\npressor\tO\neffect\tO\nin\tO\nSHR\tO\nwas\tO\nsimilar\tO\nwith\tO\nand\tO\nwithout\tO\nchronic\tO\nprazosin\tB-Chemical\ntreatment\tO\ndespite\tO\na\tO\n47\tO\n-\tO\n71\tO\n%\tO\nreduction\tO\nof\tO\nthe\tO\npressor\tO\neffect\tO\nin\tO\nchronic\tO\nalpha\tO\n1\tO\n-\tO\nreceptor\tO\nblocked\tO\nSHR\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n400\tO\nWORDS\tO\n)\tO\n\nHemolytic\tB-Disease\n-\tI-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\nassociated\tO\nwith\tO\ningestion\tO\nof\tO\nquinine\tB-Chemical\n.\tO\n\nHemolytic\tB-Disease\n-\tI-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\nfollowing\tO\nquinine\tB-Chemical\ningestion\tO\nis\tO\na\tO\nnewly\tO\ndescribed\tO\nphenomenon\tO\n,\tO\nwith\tO\njust\tO\ntwo\tO\nprevious\tO\ndescriptions\tO\nof\tO\n4\tO\ncases\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n5th\tO\ncase\tO\n.\tO\n\nThe\tO\nreaction\tO\nmay\tO\nbe\tO\nmediated\tO\nby\tO\nthe\tO\npresence\tO\nof\tO\nantibodies\tO\nreactive\tO\nagainst\tO\nplatelets\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nquinine\tB-Chemical\n.\tO\n\nTreatment\tO\nhas\tO\nincluded\tO\nuse\tO\nof\tO\nplasma\tO\nexchange\tO\n,\tO\nprednisone\tB-Chemical\n,\tO\naspirin\tB-Chemical\n,\tO\nand\tO\ndipyridamole\tB-Chemical\n.\tO\n\nThe\tO\npatients\tO\nhave\tO\nall\tO\nregained\tO\nsome\tO\ndegree\tO\nof\tO\nrenal\tO\nfunction\tO\n.\tO\n\nHowever\tO\n,\tO\nit\tO\nis\tO\nunclear\tO\nwhether\tO\npharmacological\tO\ntreatment\tO\nor\tO\nspontaneous\tO\nresolution\tO\nis\tO\nresponsible\tO\nfor\tO\nthe\tO\nimprovement\tO\n.\tO\n\nQuinine\tB-Chemical\n-\tO\nassociated\tO\nhemolytic\tB-Disease\n-\tI-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\nprobably\tO\noccurs\tO\nmore\tO\noften\tO\nthan\tO\nis\tO\nrecognized\tO\n.\tO\n\nIt\tO\nis\tO\nimportant\tO\nto\tO\nrecognize\tO\nthis\tO\nreaction\tO\nwhen\tO\nit\tO\noccurs\tO\nand\tO\nto\tO\navoid\tO\nfurther\tO\nquinine\tB-Chemical\nexposure\tO\n,\tO\nsince\tO\nthe\tO\nreaction\tO\nseems\tO\nto\tO\nbe\tO\nrecurrent\tO\n.\tO\n\nAmnestic\tB-Disease\nsyndrome\tI-Disease\nassociated\tO\nwith\tO\npropranolol\tB-Chemical\ntoxicity\tB-Disease\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nAn\tO\nelderly\tO\nwoman\tO\ndeveloped\tO\nan\tO\nAlzheimer\tB-Disease\n-\tO\nlike\tO\nsubacute\tO\ndementia\tB-Disease\nas\tO\na\tO\nresult\tO\nof\tO\npropranolol\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nAnalysis\tO\nof\tO\nthe\tO\nmanifestations\tO\nshowed\tO\nthat\tO\nsevere\tO\nimpairment\tO\nof\tO\nmemory\tO\naccounted\tO\nfor\tO\nvirtually\tO\nall\tO\nof\tO\nthe\tO\nabnormalities\tO\n.\tO\n\nThere\tO\nis\tO\nevidence\tO\nthat\tO\ncerebral\tO\nreactions\tO\nto\tO\ndrug\tO\ntoxicity\tB-Disease\ncan\tO\nexhibit\tO\npatterns\tO\nthat\tO\nsuggest\tO\nhighly\tO\nselective\tO\ninvolvement\tO\nof\tO\nfunctional\tO\nsubdivisions\tO\nof\tO\nthe\tO\nbrain\tO\n.\tO\n\nCefotetan\tB-Chemical\n-\tO\ninduced\tO\nimmune\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nImmune\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\ndue\tO\nto\tO\na\tO\ndrug\tO\n-\tO\nadsorption\tO\nmechanism\tO\nhas\tO\nbeen\tO\ndescribed\tO\nprimarily\tO\nin\tO\npatients\tO\nreceiving\tO\npenicillins\tB-Chemical\nand\tO\nfirst\tO\n-\tO\ngeneration\tO\ncephalosporins\tB-Chemical\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\npatient\tO\nwho\tO\ndeveloped\tO\nanemia\tB-Disease\nwhile\tO\nreceiving\tO\nintravenous\tO\ncefotetan\tB-Chemical\n.\tO\n\nCefotetan\tB-Chemical\n-\tO\ndependent\tO\nantibodies\tO\nwere\tO\ndetected\tO\nin\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nserum\tO\nand\tO\nin\tO\nan\tO\neluate\tO\nprepared\tO\nfrom\tO\nhis\tO\nred\tO\nblood\tO\ncells\tO\n.\tO\n\nThe\tO\neluate\tO\nalso\tO\nreacted\tO\nweakly\tO\nwith\tO\nred\tO\nblood\tO\ncells\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\ncefotetan\tB-Chemical\n,\tO\nsuggesting\tO\nthe\tO\nconcomitant\tO\nformation\tO\nof\tO\nwarm\tO\n-\tO\nreactive\tO\nautoantibodies\tO\n.\tO\n\nThese\tO\nobservations\tO\n,\tO\nin\tO\nconjunction\tO\nwith\tO\nclinical\tO\nand\tO\nlaboratory\tO\nevidence\tO\nof\tO\nextravascular\tO\nhemolysis\tB-Disease\n,\tO\nare\tO\nconsistent\tO\nwith\tO\ndrug\tO\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n,\tO\npossibly\tO\ninvolving\tO\nboth\tO\ndrug\tO\n-\tO\nadsorption\tO\nand\tO\nautoantibody\tO\nformation\tO\nmechanisms\tO\n.\tO\n\nThis\tO\ncase\tO\nemphasizes\tO\nthe\tO\nneed\tO\nfor\tO\nincreased\tO\nawareness\tO\nof\tO\nhemolytic\tO\nreactions\tO\nto\tO\nall\tO\ncephalosporins\tB-Chemical\n.\tO\n\nUse\tO\nof\tO\ndexamethasone\tB-Chemical\nwith\tO\nmesna\tB-Chemical\nfor\tO\nthe\tO\nprevention\tO\nof\tO\nifosfamide\tB-Chemical\n-\tO\ninduced\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nAIM\tO\n:\tO\nHemorrhagic\tB-Disease\ncystitis\tI-Disease\n(\tO\nHC\tB-Disease\n)\tO\nis\tO\na\tO\nlimiting\tO\nside\tO\n-\tO\neffect\tO\nof\tO\nchemotherapy\tO\nwith\tO\nifosfamide\tB-Chemical\n(\tO\nIFS\tB-Chemical\n)\tO\n.\tO\n\nIn\tO\nthe\tO\nstudy\tO\npresented\tO\nhere\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\nuse\tO\nof\tO\ndexamethasone\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nmesna\tB-Chemical\nfor\tO\nthe\tO\nprevention\tO\nof\tO\nIFS\tB-Chemical\n-\tO\ninduced\tO\nHC\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nMale\tO\nWistar\tO\nrats\tO\n(\tO\n150\tO\n-\tO\n200\tO\ng\tO\n;\tO\n6\tO\nrats\tO\nper\tO\ngroup\tO\n)\tO\nwere\tO\ntreated\tO\nwith\tO\nsaline\tO\nor\tO\nmesna\tB-Chemical\n5\tO\nmin\tO\n(\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nbefore\tO\nand\tO\n2\tO\nand\tO\n6\tO\nh\tO\nafter\tO\n(\tO\nv\tO\n.\tO\no\tO\n.\tO\n)\tO\nadministration\tO\nof\tO\nIFS\tB-Chemical\n.\tO\n\nOne\tO\n,\tO\ntwo\tO\nor\tO\nthree\tO\ndoses\tO\nof\tO\nmesna\tB-Chemical\nwere\tO\nreplaced\tO\nwith\tO\ndexamethasone\tB-Chemical\nalone\tO\nor\tO\nwith\tO\ndexamethasone\tB-Chemical\nplus\tO\nmesna\tB-Chemical\n.\tO\n\nCystitis\tB-Disease\nwas\tO\nevaluated\tO\n24\tO\nh\tO\nafter\tO\nits\tO\ninduction\tO\nby\tO\nthe\tO\nchanges\tO\nin\tO\nbladder\tO\nwet\tO\nweight\tO\nand\tO\nby\tO\nmacroscopic\tO\nand\tO\nmicroscopic\tO\nanalysis\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nreplacement\tO\nof\tO\nthe\tO\nlast\tO\ndose\tO\nor\tO\nthe\tO\nlast\tO\ntwo\tO\ndoses\tO\nof\tO\nmesna\tB-Chemical\nwith\tO\ndexamethasone\tB-Chemical\nreduced\tO\nthe\tO\nincrease\tO\nin\tO\nbladder\tO\nwet\tO\nweight\tO\ninduced\tO\nby\tO\nIFS\tB-Chemical\nby\tO\n84\tO\n.\tO\n79\tO\n%\tO\nand\tO\n89\tO\n.\tO\n13\tO\n%\tO\n,\tO\nrespectively\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nit\tO\nalmost\tO\nabolished\tO\nthe\tO\nmacroscopic\tO\nand\tO\nmicroscopic\tO\nalterations\tO\ninduced\tO\nby\tO\nIFS\tB-Chemical\n.\tO\n\nMoreover\tO\n,\tO\nthe\tO\naddition\tO\nof\tO\ndexamethasone\tB-Chemical\nto\tO\nthe\tO\nlast\tO\ntwo\tO\ndoses\tO\nof\tO\nmesna\tB-Chemical\nwas\tO\nmore\tO\nefficient\tO\nthan\tO\nthree\tO\ndoses\tO\nof\tO\nmesna\tB-Chemical\nalone\tO\nwhen\tO\nevaluated\tO\nmicroscopically\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nDexamethasone\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nmesna\tB-Chemical\nwas\tO\nefficient\tO\nin\tO\nblocking\tO\nIFS\tB-Chemical\n-\tO\ninduced\tO\nHC\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nreplacement\tO\nof\tO\nlast\tO\ntwo\tO\ndoses\tO\nof\tO\nmesna\tB-Chemical\nwith\tO\nsaline\tO\nor\tO\nall\tO\nof\tO\nthe\tO\nmesna\tB-Chemical\ndoses\tO\nwith\tO\ndexamethasone\tB-Chemical\ndid\tO\nnot\tO\nprevent\tO\nHC\tB-Disease\n.\tO\n\nAll\tB-Chemical\n-\tI-Chemical\ntrans\tI-Chemical\n-\tI-Chemical\nretinoic\tI-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nerythema\tB-Disease\nnodosum\tI-Disease\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\npromyelocytic\tI-Disease\nleukemia\tI-Disease\n.\tO\n\nErythema\tB-Disease\nnodosum\tI-Disease\nassociated\tO\nwith\tO\nall\tB-Chemical\n-\tI-Chemical\ntrans\tI-Chemical\n-\tI-Chemical\nretinoic\tI-Chemical\nacid\tI-Chemical\n(\tO\nATRA\tB-Chemical\n)\tO\nfor\tO\nacute\tB-Disease\npromyelocytic\tI-Disease\nleukemia\tI-Disease\n(\tO\nAPL\tB-Disease\n)\tO\nis\tO\nvery\tO\nrare\tO\n.\tO\n\nWe\tO\ndescribe\tO\nfour\tO\npatients\tO\nwith\tO\nclassic\tO\nAPL\tB-Disease\nwho\tO\ndeveloped\tO\nerythema\tB-Disease\nnodosum\tI-Disease\nduring\tO\nATRA\tB-Chemical\ntherapy\tO\n.\tO\n\nFever\tB-Disease\nand\tO\nsubsequent\tO\nmultiple\tO\npainful\tB-Disease\nerythematous\tB-Disease\nnodules\tI-Disease\nover\tO\nextremities\tO\ndeveloped\tO\non\tO\nD11\tO\n,\tO\nD16\tO\n,\tO\nD17\tO\n,\tO\nand\tO\nD19\tO\n,\tO\nrespectively\tO\n,\tO\nafter\tO\nATRA\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\nskin\tO\nbiopsy\tO\ntaken\tO\nfrom\tO\neach\tO\npatient\tO\nwas\tO\nconsistent\tO\nwith\tO\nerythema\tB-Disease\nnodosum\tI-Disease\n.\tO\n\nAll\tO\npatients\tO\nreceived\tO\nshort\tO\ncourse\tO\nof\tO\nsteroids\tB-Chemical\n.\tO\n\nFever\tB-Disease\nsubsided\tO\nrapidly\tO\nand\tO\nthe\tO\nskin\tO\nlesions\tO\nregressed\tO\ncompletely\tO\n.\tO\n\nAll\tO\npatients\tO\nachieved\tO\ncomplete\tO\nremission\tO\nwithout\tO\nwithdrawal\tO\nof\tO\nATRA\tB-Chemical\n.\tO\n\nATRA\tB-Chemical\nseemed\tO\nto\tO\nbe\tO\nthe\tO\nmost\tO\npossible\tO\netiology\tO\nof\tO\nerythema\tB-Disease\nnodosum\tI-Disease\nin\tO\nour\tO\npatients\tO\n.\tO\n\nShort\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nsteroid\tB-Chemical\nis\tO\nvery\tO\neffective\tO\nin\tO\nATRA\tB-Chemical\n-\tO\ninduced\tO\nerythema\tB-Disease\nnodosum\tI-Disease\n.\tO\n\nEffect\tO\nof\tO\nsome\tO\nconvulsants\tO\non\tO\nthe\tO\nprotective\tO\nactivity\tO\nof\tO\nloreclezole\tB-Chemical\nand\tO\nits\tO\ncombinations\tO\nwith\tO\nvalproate\tB-Chemical\nor\tO\nclonazepam\tB-Chemical\nin\tO\namygdala\tO\n-\tO\nkindled\tO\nrats\tO\n.\tO\n\nLoreclezole\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nexerted\tO\na\tO\nsignificant\tO\nprotective\tO\naction\tO\nin\tO\namygdala\tO\n-\tO\nkindled\tO\nrats\tO\n,\tO\nreducing\tO\nboth\tO\nseizure\tB-Disease\nand\tO\nafterdischarge\tO\ndurations\tO\n.\tO\n\nThe\tO\ncombinations\tO\nof\tO\nloreclezole\tB-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwith\tO\nvalproate\tB-Chemical\n,\tO\nclonazepam\tB-Chemical\n,\tO\nor\tO\ncarbamazepine\tB-Chemical\n(\tO\napplied\tO\nat\tO\ntheir\tO\nsubprotective\tO\ndoses\tO\n)\tO\nalso\tO\nexhibited\tO\nantiseizure\tO\neffect\tO\nin\tO\nthis\tO\ntest\tO\n.\tO\n\nHowever\tO\n,\tO\nonly\tO\ntwo\tO\nfirst\tO\ncombinations\tO\noccurred\tO\nto\tO\nbe\tO\nof\tO\npharmacodynamic\tO\nnature\tO\n.\tO\n\nAmong\tO\nseveral\tO\nchemoconvulsants\tO\n,\tO\nbicuculline\tB-Chemical\n,\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartic\tI-Chemical\nacid\tI-Chemical\nand\tO\nBAY\tB-Chemical\nk\tI-Chemical\n-\tI-Chemical\n8644\tI-Chemical\n(\tO\nthe\tO\nopener\tO\nof\tO\nL\tO\n-\tO\ntype\tO\ncalcium\tB-Chemical\nchannels\tO\n)\tO\nreversed\tO\nthe\tO\nprotective\tO\nactivity\tO\nof\tO\nloreclezole\tB-Chemical\nalone\tO\nand\tO\nits\tO\ncombination\tO\nwith\tO\nvalproate\tB-Chemical\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nbicuculline\tB-Chemical\n,\tO\naminophylline\tB-Chemical\nand\tO\nBAY\tB-Chemical\nk\tI-Chemical\n-\tI-Chemical\n8644\tI-Chemical\ninhibited\tO\nthe\tO\nanticonvulsive\tO\naction\tO\nof\tO\nloreclezole\tB-Chemical\ncombined\tO\nwith\tO\nclonazepam\tB-Chemical\n.\tO\n\nThe\tO\nresults\tO\nsupport\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\nprotective\tO\nactivity\tO\nof\tO\nloreclezole\tB-Chemical\nand\tO\nits\tO\ncombinations\tO\nwith\tO\nother\tO\nantiepileptics\tO\nmay\tO\ninvolve\tO\npotentiation\tO\nof\tO\nGABAergic\tO\nneurotransmission\tO\nand\tO\nblockade\tO\nof\tO\nL\tO\n-\tO\ntype\tO\nof\tO\ncalcium\tB-Chemical\nchannels\tO\n.\tO\n\nMitochondrial\tO\nDNA\tO\nand\tO\nits\tO\nrespiratory\tO\nchain\tO\nproducts\tO\nare\tO\ndefective\tO\nin\tO\ndoxorubicin\tB-Chemical\nnephrosis\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nDoxorubicin\tB-Chemical\ninduces\tO\na\tO\nself\tO\n-\tO\nperpetuating\tO\nnephropathy\tB-Disease\ncharacterized\tO\nby\tO\nearly\tO\nglomerular\tB-Disease\nand\tI-Disease\nlate\tI-Disease\n-\tI-Disease\nonset\tI-Disease\ntubular\tI-Disease\nlesions\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\npotential\tO\nrole\tO\nof\tO\nmitochondrial\tB-Disease\ninjury\tI-Disease\nin\tO\nthe\tO\nonset\tO\nof\tO\nthese\tO\nlesions\tO\n.\tO\n\nMETHODS\tO\n:\tO\nRats\tO\nwere\tO\ntreated\tO\nwith\tO\nintravenous\tO\ndoxorubicin\tB-Chemical\n(\tO\n1\tO\nmg\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\nweek\tO\n(\tO\n-\tO\n1\tO\n)\tO\n)\tO\nfor\tO\n7\tO\nweeks\tO\nand\tO\nwere\tO\nsacrificed\tO\neither\tO\n1\tO\nweek\tO\n(\tO\n'\tO\nshort\tO\n-\tO\nterm\tO\n'\tO\n)\tO\nor\tO\n30\tO\nweeks\tO\n(\tO\n'\tO\nlong\tO\n-\tO\nterm\tO\n'\tO\n)\tO\nfollowing\tO\nthe\tO\nlast\tO\ndose\tO\n.\tO\n\nAdditional\tO\nrats\tO\nreceived\tO\na\tO\nsingle\tO\ndose\tO\neither\tO\n6\tO\ndays\tO\nor\tO\n2\tO\nh\tO\nprior\tO\nto\tO\neuthanasia\tO\n.\tO\n\nAll\tO\nrats\tO\nwere\tO\nkilled\tO\nat\tO\n48\tO\nweeks\tO\nof\tO\nage\tO\n.\tO\n\nGlomerular\tB-Disease\nand\tI-Disease\ntubular\tI-Disease\ninjury\tI-Disease\nwas\tO\nmonitored\tO\nand\tO\ncorrelated\tO\nto\tO\nthe\tO\nactivity\tO\nor\tO\nexpression\tO\nof\tO\nrespiratory\tO\nchain\tO\ncomponents\tO\n.\tO\n\nFinally\tO\n,\tO\nwe\tO\nquantified\tO\nboth\tO\nnuclear\tO\nand\tO\nmitochondrial\tO\nDNA\tO\n(\tO\nmtDNA\tO\n)\tO\nas\tO\nwell\tO\nas\tO\nsuperoxide\tB-Chemical\nproduction\tO\nand\tO\nthe\tO\n4834\tO\nbase\tO\npair\tO\n'\tO\ncommon\tO\n'\tO\nmtDNA\tO\ndeletion\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\n'\tO\nlong\tO\n-\tO\nterm\tO\n'\tO\ngroup\tO\nhad\tO\nsignificant\tO\nglomerular\tB-Disease\nand\tI-Disease\ntubular\tI-Disease\nlesions\tI-Disease\n,\tO\ndepressed\tO\nactivities\tO\nof\tO\nmtDNA\tO\n-\tO\nencoded\tO\nNADH\tO\ndehydrogenase\tO\nand\tO\ncytochrome\tO\n-\tO\nc\tO\noxidase\tO\n(\tO\nCOX\tO\n)\tO\nand\tO\nincreased\tO\ncitrate\tB-Chemical\nsynthase\tO\nactivity\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nexpression\tO\nof\tO\nthe\tO\nmtDNA\tO\n-\tO\nencoded\tO\nCOX\tO\nsubunit\tO\nI\tO\nwas\tO\nreduced\tO\nand\tO\nmtDNA\tO\nlevels\tO\nwere\tO\ndecreased\tO\n.\tO\n\nIn\tO\n'\tO\nshort\tO\n-\tO\nterm\tO\n'\tO\nrats\tO\n,\tO\nthere\tO\nwere\tO\nfewer\tO\ntubular\tB-Disease\nlesions\tI-Disease\n,\tO\nbut\tO\nsimilar\tO\nnumbers\tO\nof\tO\nglomerular\tB-Disease\nlesions\tI-Disease\nactivity\tO\n.\tO\n\nAmong\tO\nall\tO\nanimals\tO\n,\tO\nglomerular\tB-Disease\nand\tI-Disease\ntubular\tI-Disease\ninjury\tI-Disease\nwere\tO\ninversely\tO\ncorrelated\tO\nwith\tO\nmtDNA\tO\nlevels\tO\n,\tO\nmtDNA\tO\n-\tO\nencoded\tO\nrespiratory\tO\nchain\tO\nactivities\tO\nand\tO\nwith\tO\nthe\tO\nexpression\tO\nof\tO\nthe\tO\nmtDNA\tO\n-\tO\nencoded\tO\nrespiratory\tO\nchain\tO\nsubunit\tO\nCOX\tO\n-\tO\nI\tO\n.\tO\n\nInjury\tO\nwas\tO\npositively\tO\ncorrelated\tO\nwith\tO\nsuperoxide\tB-Chemical\nproduction\tO\nand\tO\nthe\tO\nactivities\tO\nof\tO\nnucleus\tO\n-\tO\nencoded\tO\nmitochondrial\tO\nor\tO\ncytoplasmic\tO\nenzymes\tO\n.\tO\n\nKidneys\tO\nfrom\tO\nthe\tO\n'\tO\nlong\tO\n-\tO\nterm\tO\n'\tO\ngroup\tO\nshowed\tO\nmore\tO\nmtDNA\tO\ndeletions\tO\nthan\tO\nin\tO\n'\tO\nshort\tO\n-\tO\nterm\tO\n'\tO\nanimals\tO\nand\tO\nthese\tO\nwere\tO\nnot\tO\nobserved\tO\nin\tO\nthe\tO\nother\tO\ngroups\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nsuggest\tO\nan\tO\nimportant\tO\nrole\tO\nfor\tO\nquantitative\tO\nand\tO\nqualitative\tO\nmtDNA\tO\nalterations\tO\nthrough\tO\nthe\tO\nreduction\tO\nof\tO\nmtDNA\tO\n-\tO\nencoded\tO\nrespiratory\tO\nchain\tO\nfunction\tO\nand\tO\ninduction\tO\nof\tO\nsuperoxide\tB-Chemical\nin\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\nlesions\tI-Disease\n.\tO\n\nA\tO\nrandomized\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ncrossover\tO\nstudy\tO\nof\tO\nephedrine\tB-Chemical\nfor\tO\nSSRI\tO\n-\tO\ninduced\tO\nfemale\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nwhether\tO\nephedrine\tB-Chemical\n,\tO\nan\tO\nalpha\tO\n-\tO\nand\tO\nbeta\tO\n-\tO\nadrenergic\tO\nagonist\tO\npreviously\tO\nshown\tO\nto\tO\nenhance\tO\ngenital\tO\nblood\tO\nflow\tO\nin\tO\nwomen\tO\n,\tO\nhas\tO\nbeneficial\tO\neffects\tO\nin\tO\nreversing\tO\nantidepressant\tO\n-\tO\ninduced\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nNineteen\tO\nsexually\tB-Disease\ndysfunctional\tI-Disease\nwomen\tO\nreceiving\tO\neither\tO\nfluoxetine\tB-Chemical\n,\tO\nsertraline\tB-Chemical\n,\tO\nor\tO\nparoxetine\tB-Chemical\nparticipated\tO\nin\tO\nan\tO\neight\tO\n-\tO\nweek\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ncross\tO\n-\tO\nover\tO\nstudy\tO\nof\tO\nthe\tO\neffects\tO\nof\tO\nephedrine\tB-Chemical\n(\tO\n50\tO\nmg\tO\n)\tO\non\tO\nself\tO\n-\tO\nreport\tO\nmeasures\tO\nof\tO\nsexual\tO\ndesire\tO\n,\tO\narousal\tO\n,\tO\norgasm\tO\n,\tO\nand\tO\nsexual\tO\nsatisfaction\tO\n.\tO\n\nAlthough\tO\nthere\tO\nwere\tO\nsignificant\tO\nimprovements\tO\nrelative\tO\nto\tO\nbaseline\tO\nin\tO\nsexual\tO\ndesire\tO\nand\tO\norgasm\tO\nintensity\tO\n/\tO\npleasure\tO\non\tO\n50\tO\nmg\tO\nephedrine\tB-Chemical\n1\tO\n-\tO\nhr\tO\nprior\tO\nto\tO\nsexual\tO\nactivity\tO\n,\tO\nsignificant\tO\nimprovements\tO\nin\tO\nthese\tO\nmeasures\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nin\tO\nsexual\tO\narousal\tO\nand\tO\norgasmic\tO\nability\tO\nalso\tO\nwere\tO\nnoted\tO\nwith\tO\nplacebo\tO\n.\tO\n\nThese\tO\nfindings\tO\nhighlight\tO\nthe\tO\nimportance\tO\nof\tO\nconducting\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrials\tO\nfor\tO\nthis\tO\ncondition\tO\n.\tO\n\nDoes\tO\nhormone\tO\ntherapy\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\nhave\tO\na\tO\ndetrimental\tB-Disease\neffect\tI-Disease\non\tI-Disease\nmemory\tI-Disease\nand\tI-Disease\ncognition\tI-Disease\n?\tO\n\nA\tO\npilot\tO\nstudy\tO\n.\tO\n\nThis\tO\npilot\tO\nstudy\tO\nexamines\tO\nwhether\tO\nhormone\tO\ntherapy\tO\nfor\tO\nbreast\tB-Disease\ncancer\tI-Disease\naffects\tO\ncognition\tO\n.\tO\n\nPatients\tO\nparticipating\tO\nin\tO\na\tO\nrandomised\tO\ntrial\tO\nof\tO\nanastrozole\tB-Chemical\n,\tO\ntamoxifen\tB-Chemical\nalone\tO\nor\tO\ncombined\tO\n(\tO\nATAC\tO\n)\tO\n(\tO\nn\tO\n=\tO\n94\tO\n)\tO\nand\tO\na\tO\ngroup\tO\nof\tO\nwomen\tO\nwithout\tO\nbreast\tB-Disease\ncancer\tI-Disease\n(\tO\nn\tO\n=\tO\n35\tO\n)\tO\ncompleted\tO\na\tO\nbattery\tO\nof\tO\nneuropsychological\tO\nmeasures\tO\n.\tO\n\nCompared\tO\nwith\tO\nthe\tO\ncontrol\tO\ngroup\tO\n,\tO\nthe\tO\npatients\tO\nwere\tO\nimpaired\tO\non\tO\na\tO\nprocessing\tO\nspeed\tO\ntask\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n032\tO\n)\tO\nand\tO\non\tO\na\tO\nmeasure\tO\nof\tO\nimmediate\tO\nverbal\tO\nmemory\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n026\tO\n)\tO\nafter\tO\ncontrolling\tO\nfor\tO\nthe\tO\nuse\tO\nof\tO\nhormone\tO\nreplacement\tO\ntherapy\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nPatient\tO\ngroup\tO\nperformance\tO\nwas\tO\nnot\tO\nsignificantly\tO\nrelated\tO\nto\tO\nlength\tO\nof\tO\ntreatment\tO\nor\tO\nmeasures\tO\nof\tO\npsychological\tO\nmorbidity\tO\n.\tO\n\nThe\tO\nresults\tO\nshowed\tO\nspecific\tO\nimpairments\tO\nin\tO\nprocessing\tO\nspeed\tO\nand\tO\nverbal\tO\nmemory\tO\nin\tO\nwomen\tO\nreceiving\tO\nhormonal\tO\ntherapy\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nVerbal\tO\nmemory\tO\nmay\tO\nbe\tO\nespecially\tO\nsensitive\tO\nto\tO\nchanges\tO\nin\tO\noestrogen\tB-Chemical\nlevels\tO\n,\tO\na\tO\nfinding\tO\ncommonly\tO\nreported\tO\nin\tO\nstudies\tO\nof\tO\nhormone\tO\nreplacement\tO\ntherapy\tO\nin\tO\nhealthy\tO\nwomen\tO\n.\tO\n\nIn\tO\nview\tO\nof\tO\nthe\tO\nincreased\tO\nuse\tO\nof\tO\nhormone\tO\ntherapies\tO\nin\tO\nan\tO\nadjuvant\tO\nand\tO\npreventative\tO\nsetting\tO\ntheir\tO\nimpact\tO\non\tO\ncognitive\tO\nfunctioning\tO\nshould\tO\nbe\tO\ninvestigated\tO\nmore\tO\nthoroughly\tO\n.\tO\n\nExpression\tO\nof\tO\np300\tO\nprotects\tO\ncardiac\tO\nmyocytes\tO\nfrom\tO\napoptosis\tO\nin\tO\nvivo\tO\n.\tO\n\nDoxorubicin\tB-Chemical\nis\tO\nan\tO\nanti\tO\n-\tO\ntumor\tB-Disease\nagent\tO\nthat\tO\nrepresses\tO\ncardiac\tO\n-\tO\nspecific\tO\ngene\tO\nexpression\tO\nand\tO\ninduces\tO\nmyocardial\tO\ncell\tO\napoptosis\tO\n.\tO\n\nDoxorubicin\tB-Chemical\ndepletes\tO\ncardiac\tO\np300\tO\n,\tO\na\tO\ntranscriptional\tO\ncoactivator\tO\nthat\tO\nis\tO\nrequired\tO\nfor\tO\nthe\tO\nmaintenance\tO\nof\tO\nthe\tO\ndifferentiated\tO\nphenotype\tO\nof\tO\ncardiac\tO\nmyocytes\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nrole\tO\nof\tO\np300\tO\nin\tO\nprotection\tO\nagainst\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\napoptosis\tO\nis\tO\nunknown\tO\n.\tO\n\nTransgenic\tO\nmice\tO\noverexpressing\tO\np300\tO\nin\tO\nthe\tO\nheart\tO\nand\tO\nwild\tO\n-\tO\ntype\tO\nmice\tO\nwere\tO\nsubjected\tO\nto\tO\ndoxorubicin\tB-Chemical\ntreatment\tO\n.\tO\n\nCompared\tO\nwith\tO\nwild\tO\n-\tO\ntype\tO\nmice\tO\n,\tO\ntransgenic\tO\nmice\tO\nexhibited\tO\nhigher\tO\nsurvival\tO\nrate\tO\nas\tO\nwell\tO\nas\tO\nmore\tO\npreserved\tO\nleft\tO\nventricular\tO\nfunction\tO\nand\tO\ncardiac\tO\nexpression\tO\nof\tO\nalpha\tO\n-\tO\nsarcomeric\tO\nactin\tO\n.\tO\n\nDoxorubicin\tB-Chemical\ninduced\tO\nmyocardial\tO\ncell\tO\napoptosis\tO\nin\tO\nwild\tO\n-\tO\ntype\tO\nmice\tO\nbut\tO\nnot\tO\nin\tO\ntransgenic\tO\nmice\tO\n.\tO\n\nExpression\tO\nof\tO\np300\tO\nincreased\tO\nthe\tO\ncardiac\tO\nlevel\tO\nof\tO\nbcl\tO\n-\tO\n2\tO\nand\tO\nmdm\tO\n-\tO\n2\tO\n,\tO\nbut\tO\nnot\tO\nthat\tO\nof\tO\np53\tO\nor\tO\nother\tO\nmembers\tO\nof\tO\nthe\tO\nbcl\tO\n-\tO\n2\tO\nfamily\tO\n.\tO\n\nThese\tO\nfindings\tO\ndemonstrate\tO\nthat\tO\noverexpression\tO\nof\tO\np300\tO\nprotects\tO\ncardiac\tO\nmyocytes\tO\nfrom\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\napoptosis\tO\nand\tO\nreduces\tO\nthe\tO\nextent\tO\nof\tO\nacute\tO\nheart\tB-Disease\nfailure\tI-Disease\nin\tO\nadult\tO\nmice\tO\nin\tO\nvivo\tO\n.\tO\n\nMethimazole\tB-Chemical\n-\tO\ninduced\tO\ncholestatic\tB-Disease\njaundice\tI-Disease\n.\tO\n\nMethimazole\tB-Chemical\nis\tO\na\tO\nwidely\tO\nused\tO\nand\tO\ngenerally\tO\nwell\tO\n-\tO\ntolerated\tO\nantithyroid\tO\nagent\tO\n.\tO\n\nA\tO\n43\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nhad\tO\nsevere\tO\njaundice\tB-Disease\nand\tO\nitching\tB-Disease\n1\tO\nmonth\tO\nafter\tO\nreceiving\tO\nmethimazole\tB-Chemical\n(\tO\n10\tO\nmg\tO\ntid\tO\n)\tO\nand\tO\npropranolol\tB-Chemical\n(\tO\n20\tO\nmg\tO\ntid\tO\n)\tO\nfor\tO\ntreatment\tO\nof\tO\nhyperthyroidism\tB-Disease\n.\tO\n\nThe\tO\npatient\tO\ncontinued\tO\ntreatment\tO\nfor\tO\nanother\tO\n4\tO\ndays\tO\nafter\tO\nthe\tO\nappearance\tO\nof\tO\njaundice\tB-Disease\nuntil\tO\nshe\tO\nfinished\tO\nboth\tO\nmedications\tO\n.\tO\n\nWhen\tO\nseen\tO\nat\tO\nthe\tO\nemergency\tO\ndepartment\tO\n2\tO\nweeks\tO\nlater\tO\n,\tO\nshe\tO\nstill\tO\nhad\tO\nsevere\tO\nicterus\tB-Disease\n,\tO\npruritus\tB-Disease\n,\tO\nand\tO\nhyperbilirubinemia\tB-Disease\n,\tO\nformed\tO\nmainly\tO\nof\tO\nthe\tO\nconjugated\tO\nfraction\tO\n.\tO\n\nMethimazole\tB-Chemical\n-\tO\ninduced\tO\ncholestasis\tB-Disease\nwas\tO\ndiagnosed\tO\n,\tO\nand\tO\npropranolol\tB-Chemical\ntherapy\tO\nwas\tO\nresumed\tO\n.\tO\n\nOver\tO\nthe\tO\nfollowing\tO\n9\tO\ndays\tO\n,\tO\nthe\tO\nsymptoms\tO\nimproved\tO\nand\tO\nplasma\tO\nbilirubin\tB-Chemical\nlevels\tO\nwere\tO\nnormal\tO\nafter\tO\n12\tO\nweeks\tO\nwithout\tO\nmethimazole\tB-Chemical\n.\tO\n\nIn\tO\nrare\tO\ncases\tO\nwithin\tO\nthe\tO\nfirst\tO\nfew\tO\nweeks\tO\nof\tO\ntherapy\tO\n,\tO\nthis\tO\ndrug\tO\ncan\tO\ncause\tO\nsevere\tO\nand\tO\nreversible\tO\ncholestatic\tB-Disease\njaundice\tI-Disease\n.\tO\n\nPhysicians\tO\nand\tO\npatients\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\nadverse\tO\neffect\tO\nso\tO\nthat\tO\n,\tO\nupon\tO\noccurrence\tO\n,\tO\nthey\tO\ncan\tO\ndiscontinue\tO\nmethimazole\tB-Chemical\ntherapy\tO\nand\tO\navoid\tO\nunnecessary\tO\ninvasive\tO\nprocedures\tO\n.\tO\n\nAtrial\tB-Disease\nfibrillation\tI-Disease\nfollowing\tO\nchemotherapy\tO\nfor\tO\nstage\tO\nIIIE\tO\ndiffuse\tO\nlarge\tO\nB\tO\n-\tO\ncell\tO\ngastric\tB-Disease\nlymphoma\tI-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nmyotonic\tB-Disease\ndystrophy\tI-Disease\n(\tO\nSteinert\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n)\tO\n.\tO\n\nThe\tO\nauthors\tO\ndescribe\tO\nthe\tO\nunusual\tO\nassociation\tO\nbetween\tO\ndiffuse\tO\nB\tO\n-\tO\ncell\tO\ngastric\tB-Disease\nlymphoma\tI-Disease\nand\tO\nmyotonic\tB-Disease\ndystrophy\tI-Disease\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nform\tO\nof\tO\nadult\tO\nmuscular\tB-Disease\ndystrophy\tI-Disease\n,\tO\nand\tO\nsudden\tO\natrial\tB-Disease\nfibrillation\tI-Disease\nfollowing\tO\none\tO\ncycle\tO\nof\tO\ndoxorubicin\tB-Chemical\n-\tO\nbased\tO\nchemotherapy\tO\nin\tO\nthe\tO\nsame\tO\npatient\tO\n.\tO\n\nAtrial\tB-Disease\nfibrillation\tI-Disease\nor\tO\nother\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\nare\tO\nunusual\tO\ncomplications\tO\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nchemotherapy\tO\n.\tO\n\nThe\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nintrinsically\tO\nassociated\tO\nwith\tO\nthe\tO\naggressive\tO\nchemotherapy\tO\nemployed\tO\ncould\tO\nfunction\tO\nas\tO\na\tO\ntriggering\tO\nfactor\tO\nfor\tO\nthe\tO\narrhythmia\tB-Disease\nin\tO\nthe\tO\npredisposed\tO\nmyocardium\tO\nof\tO\nthis\tO\npatient\tO\n.\tO\n\nHypersensitivity\tB-Disease\nimmune\tO\nreaction\tO\nas\tO\na\tO\nmechanism\tO\nfor\tO\ndilevalol\tB-Chemical\n-\tO\nassociated\tO\nhepatitis\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nassess\tO\nlymphocyte\tO\nreactivity\tO\nto\tO\ndilevalol\tB-Chemical\nand\tO\nto\tO\nserum\tO\ncontaining\tO\nputative\tO\nex\tO\nvivo\tO\ndilevalol\tB-Chemical\nantigens\tO\nor\tO\nmetabolites\tO\nin\tO\na\tO\ncase\tO\nof\tO\ndilevalol\tB-Chemical\n-\tO\ninduced\tO\nliver\tB-Disease\ninjury\tI-Disease\n.\tO\n\nPATIENT\tO\n:\tO\nA\tO\n58\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\na\tO\nclinical\tO\ndiagnosis\tO\nof\tO\ndilevalol\tB-Chemical\n-\tO\ninduced\tO\nliver\tB-Disease\ninjury\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nPeripheral\tO\nblood\tO\nmononuclear\tO\ncells\tO\ncollected\tO\nfrom\tO\nthe\tO\npatient\tO\nwere\tO\ncultured\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\na\tO\nsolution\tO\nof\tO\ndilevalol\tB-Chemical\nand\tO\nalso\tO\nwith\tO\nsera\tO\ncollected\tO\nfrom\tO\na\tO\nvolunteer\tO\nbefore\tO\nand\tO\nafter\tO\ndilevalol\tB-Chemical\nintake\tO\n.\tO\n\nA\tO\nsimilar\tO\nprotocol\tO\nwas\tO\nperformed\tO\nwith\tO\nlymphocytes\tO\nfrom\tO\na\tO\nhealthy\tO\nsubject\tO\n.\tO\n\nRESULTS\tO\n:\tO\nNo\tO\nlymphocyte\tO\nproliferation\tO\nwas\tO\nobserved\tO\neither\tO\nin\tO\nthe\tO\npatient\tO\nor\tO\nin\tO\nthe\tO\nhealthy\tO\nvolunteer\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\ndilevalol\tB-Chemical\nsolutions\tO\n.\tO\n\nA\tO\nsignificant\tO\nproliferative\tO\nresponse\tO\nto\tO\nserum\tO\ncollected\tO\nafter\tO\ndilevalol\tB-Chemical\nintake\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\ncase\tO\nof\tO\nthe\tO\npatient\tO\ncompared\tO\nwith\tO\nthe\tO\nproliferative\tO\nresponse\tO\nto\tO\nthe\tO\nserum\tO\ncollected\tO\nbefore\tO\nthe\tO\ndrug\tO\nintake\tO\n.\tO\n\nNo\tO\nreactivity\tO\nwas\tO\nfound\tO\nwhen\tO\nlymphocytes\tO\nfrom\tO\nthe\tO\nhealthy\tO\nsubject\tO\nwere\tO\ntested\tO\nunder\tO\nsimilar\tO\nconditions\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nmethodology\tO\nused\tO\nallowed\tO\nthe\tO\ndetection\tO\nof\tO\nlymphocyte\tO\nsensitization\tO\nto\tO\nsera\tO\ncontaining\tO\nex\tO\nvivo\tO\n-\tO\nprepared\tO\ndilevalol\tB-Chemical\nantigens\tO\n,\tO\nsuggesting\tO\nthe\tO\ninvolvement\tO\nof\tO\nan\tO\nimmunologic\tO\nmechanism\tO\nin\tO\ndilevalol\tB-Chemical\n-\tO\ninduced\tO\nliver\tB-Disease\ninjury\tI-Disease\n.\tO\n\nIncreased\tO\nexpression\tO\nand\tO\napical\tO\ntargeting\tO\nof\tO\nrenal\tO\nENaC\tO\nsubunits\tO\nin\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nNephrotic\tB-Disease\nsyndrome\tI-Disease\nis\tO\noften\tO\naccompanied\tO\nby\tO\nsodium\tB-Chemical\nretention\tO\nand\tO\ngeneralized\tO\nedema\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmolecular\tO\nbasis\tO\nfor\tO\nthe\tO\ndecreased\tO\nrenal\tO\nsodium\tB-Chemical\nexcretion\tO\nremains\tO\nundefined\tO\n.\tO\n\nWe\tO\nhypothesized\tO\nthat\tO\nepithelial\tO\nNa\tB-Chemical\nchannel\tO\n(\tO\nENaC\tO\n)\tO\nsubunit\tO\ndysregulation\tO\nmay\tO\nbe\tO\nresponsible\tO\nfor\tO\nthe\tO\nincreased\tO\nsodium\tB-Chemical\nretention\tO\n.\tO\n\nAn\tO\nexperimental\tO\ngroup\tO\nof\tO\nrats\tO\nwas\tO\ntreated\tO\nwith\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n;\tO\n180\tO\nmg\tO\n/\tO\nkg\tO\niv\tO\n)\tO\n,\tO\nwhereas\tO\nthe\tO\ncontrol\tO\ngroup\tO\nreceived\tO\nonly\tO\nvehicle\tO\n.\tO\n\nAfter\tO\n7\tO\ndays\tO\n,\tO\nPAN\tB-Chemical\ntreatment\tO\ninduced\tO\nsignificant\tO\nproteinuria\tB-Disease\n,\tO\nhypoalbuminemia\tB-Disease\n,\tO\ndecreased\tO\nurinary\tO\nsodium\tB-Chemical\nexcretion\tO\n,\tO\nand\tO\nextensive\tO\nascites\tB-Disease\n.\tO\n\nThe\tO\nprotein\tO\nabundance\tO\nof\tO\nalpha\tO\n-\tO\nENaC\tO\nand\tO\nbeta\tO\n-\tO\nENaC\tO\nwas\tO\nincreased\tO\nin\tO\nthe\tO\ninner\tO\nstripe\tO\nof\tO\nthe\tO\nouter\tO\nmedulla\tO\n(\tO\nISOM\tO\n)\tO\nand\tO\nin\tO\nthe\tO\ninner\tO\nmedulla\tO\n(\tO\nIM\tO\n)\tO\nbut\tO\nwas\tO\nnot\tO\naltered\tO\nin\tO\nthe\tO\ncortex\tO\n.\tO\n\ngamma\tO\n-\tO\nENaC\tO\nabundance\tO\nwas\tO\nincreased\tO\nin\tO\nthe\tO\ncortex\tO\n,\tO\nISOM\tO\n,\tO\nand\tO\nIM\tO\n.\tO\n\nImmunoperoxidase\tO\nbrightfield\tO\n-\tO\nand\tO\nlaser\tO\n-\tO\nscanning\tO\nconfocal\tO\nfluorescence\tO\nmicroscopy\tO\ndemonstrated\tO\nincreased\tO\ntargeting\tO\nof\tO\nalpha\tO\n-\tO\nENaC\tO\n,\tO\nbeta\tO\n-\tO\nENaC\tO\n,\tO\nand\tO\ngamma\tO\n-\tO\nENaC\tO\nsubunits\tO\nto\tO\nthe\tO\napical\tO\nplasma\tO\nmembrane\tO\nin\tO\nthe\tO\ndistal\tO\nconvoluted\tO\ntubule\tO\n(\tO\nDCT2\tO\n)\tO\n,\tO\nconnecting\tO\ntubule\tO\n,\tO\nand\tO\ncortical\tO\nand\tO\nmedullary\tO\ncollecting\tO\nduct\tO\nsegments\tO\n.\tO\n\nImmunoelectron\tO\nmicroscopy\tO\nfurther\tO\nrevealed\tO\nan\tO\nincreased\tO\nlabeling\tO\nof\tO\nalpha\tO\n-\tO\nENaC\tO\nin\tO\nthe\tO\napical\tO\nplasma\tO\nmembrane\tO\nof\tO\ncortical\tO\ncollecting\tO\nduct\tO\nprincipal\tO\ncells\tO\nof\tO\nPAN\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n,\tO\nindicating\tO\nenhanced\tO\napical\tO\ntargeting\tO\nof\tO\nalpha\tO\n-\tO\nENaC\tO\nsubunits\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthe\tO\nprotein\tO\nabundances\tO\nof\tO\nNa\tB-Chemical\n(\tO\n+\tO\n)\tO\n/\tO\nH\tB-Chemical\n(\tO\n+\tO\n)\tO\nexchanger\tO\ntype\tO\n3\tO\n(\tO\nNHE3\tO\n)\tO\n,\tO\nNa\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\n2Cl\tB-Chemical\n(\tO\n-\tO\n)\tO\ncotransporter\tO\n(\tO\nBSC\tO\n-\tO\n1\tO\n)\tO\n,\tO\nand\tO\nthiazide\tB-Chemical\n-\tO\nsensitive\tO\nNa\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nCl\tB-Chemical\n(\tO\n-\tO\n)\tO\ncotransporter\tO\n(\tO\nTSC\tO\n)\tO\nwere\tO\ndecreased\tO\n.\tO\n\nMoreover\tO\n,\tO\nthe\tO\nabundance\tO\nof\tO\nthe\tO\nalpha\tO\n(\tO\n1\tO\n)\tO\n-\tO\nsubunit\tO\nof\tO\nthe\tO\nNa\tB-Chemical\n-\tO\nK\tB-Chemical\n-\tO\nATPase\tO\nwas\tO\ndecreased\tO\nin\tO\nthe\tO\ncortex\tO\nand\tO\nISOM\tO\n,\tO\nbut\tO\nit\tO\nremained\tO\nunchanged\tO\nin\tO\nthe\tO\nIM\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\nincreased\tO\nor\tO\nsustained\tO\nexpression\tO\nof\tO\nENaC\tO\nsubunits\tO\ncombined\tO\nwith\tO\nincreased\tO\napical\tO\ntargeting\tO\nin\tO\nthe\tO\nDCT2\tO\n,\tO\nconnecting\tO\ntubule\tO\n,\tO\nand\tO\ncollecting\tO\nduct\tO\nare\tO\nlikely\tO\nto\tO\nplay\tO\na\tO\nrole\tO\nin\tO\nthe\tO\nsodium\tB-Chemical\nretention\tO\nassociated\tO\nwith\tO\nPAN\tB-Chemical\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\ndecreased\tO\nabundance\tO\nof\tO\nNHE3\tO\n,\tO\nBSC\tO\n-\tO\n1\tO\n,\tO\nTSC\tO\n,\tO\nand\tO\nNa\tB-Chemical\n-\tO\nK\tB-Chemical\n-\tO\nATPase\tO\nmay\tO\nplay\tO\na\tO\ncompensatory\tO\nrole\tO\nto\tO\npromote\tO\nsodium\tB-Chemical\nexcretion\tO\n.\tO\n\nPallidal\tO\nstimulation\tO\n:\tO\nan\tO\nalternative\tO\nto\tO\npallidotomy\tO\n?\tO\n\nA\tO\nresurgence\tO\nof\tO\ninterest\tO\nin\tO\nthe\tO\nsurgical\tO\ntreatment\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\ncame\tO\nwith\tO\nthe\tO\nrediscovery\tO\nof\tO\nposteroventral\tO\npallidotomy\tO\nby\tO\nLaitinen\tO\nin\tO\n1985\tO\n.\tO\n\nLaitinen\tO\n'\tO\ns\tO\nprocedure\tO\nimproved\tO\nmost\tO\nsymptoms\tO\nin\tO\ndrug\tO\n-\tO\nresistant\tO\nPD\tB-Disease\n,\tO\nwhich\tO\nengendered\tO\nwide\tO\ninterest\tO\nin\tO\nthe\tO\nneurosurgical\tO\ncommunity\tO\n.\tO\n\nAnother\tO\nlesioning\tO\nprocedure\tO\n,\tO\nventrolateral\tO\nthalamotomy\tO\n,\tO\nhas\tO\nbecome\tO\na\tO\npowerful\tO\nalternative\tO\nto\tO\nstimulate\tO\nthe\tO\nnucleus\tO\nventralis\tO\nintermedius\tO\n,\tO\nproducing\tO\nhigh\tO\nlong\tO\n-\tO\nterm\tO\nsuccess\tO\nrates\tO\nand\tO\nlow\tO\nmorbidity\tO\nrates\tO\n.\tO\n\nPallidal\tO\nstimulation\tO\nhas\tO\nnot\tO\nmet\tO\nwith\tO\nthe\tO\nsame\tO\nsuccess\tO\n.\tO\n\nAccording\tO\nto\tO\nthe\tO\nliterature\tO\npallidotomy\tO\nimproves\tO\nthe\tO\n\"\tO\non\tO\n\"\tO\nsymptoms\tO\nof\tO\nPD\tB-Disease\n,\tO\nsuch\tO\nas\tO\ndyskinesias\tB-Disease\n,\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\n\"\tO\noff\tO\n\"\tO\nsymptoms\tO\n,\tO\nsuch\tO\nas\tO\nrigidity\tB-Disease\n,\tO\nbradykinesia\tB-Disease\n,\tO\nand\tO\non\tO\n-\tO\noff\tO\nfluctuations\tO\n.\tO\n\nPallidal\tO\nstimulation\tO\nimproves\tO\nbradykinesia\tB-Disease\nand\tO\nrigidity\tB-Disease\nto\tO\na\tO\nminor\tO\nextent\tO\n;\tO\nhowever\tO\n,\tO\nits\tO\nstrength\tO\nseems\tO\nto\tO\nbe\tO\nin\tO\nimproving\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n.\tO\n\nStimulation\tO\noften\tO\nproduces\tO\nan\tO\nimprovement\tO\nin\tO\nthe\tO\nhyper\tB-Disease\n-\tI-Disease\nor\tI-Disease\ndyskinetic\tI-Disease\nupper\tO\nlimbs\tO\n,\tO\nbut\tO\nincreases\tO\nthe\tO\n\"\tO\nfreezing\tO\n\"\tO\nphenomenon\tO\nin\tO\nthe\tO\nlower\tO\nlimbs\tO\nat\tO\nthe\tO\nsame\tO\ntime\tO\n.\tO\n\nConsidering\tO\nthe\tO\nsmall\tO\nincrease\tO\nin\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nindependence\tO\n,\tO\nthe\tO\nhigh\tO\ncosts\tO\nof\tO\nbilateral\tO\nimplants\tO\n,\tO\nand\tO\nthe\tO\ndifficulty\tO\nmost\tO\npatients\tO\nexperience\tO\nin\tO\nhandling\tO\nthe\tO\ndevices\tO\n,\tO\nthe\tO\nquestion\tO\narises\tO\nas\tO\nto\tO\nwhether\tO\nbilateral\tO\npallidal\tO\nstimulation\tO\nis\tO\na\tO\nreal\tO\nalternative\tO\nto\tO\npallidotomy\tO\n.\tO\n\nEffects\tO\nof\tO\nthe\tO\ncyclooxygenase\tO\n-\tO\n2\tO\nspecific\tO\ninhibitor\tO\nvaldecoxib\tB-Chemical\nversus\tO\nnonsteroidal\tO\nantiinflammatory\tO\nagents\tO\nand\tO\nplacebo\tO\non\tO\ncardiovascular\tO\nthrombotic\tB-Disease\nevents\tO\nin\tO\npatients\tO\nwith\tO\narthritis\tB-Disease\n.\tO\n\nThere\tO\nhave\tO\nbeen\tO\nconcerns\tO\nthat\tO\nthe\tO\nrisk\tO\nof\tO\ncardiovascular\tO\nthrombotic\tB-Disease\nevents\tO\nmay\tO\nbe\tO\nhigher\tO\nwith\tO\ncyclooxygenase\tO\n(\tO\nCOX\tO\n)\tO\n-\tO\n2\tO\n-\tO\nspecific\tO\ninhibitors\tO\nthan\tO\nnonselective\tO\nnonsteroidal\tO\nantiinflammatory\tO\ndrugs\tO\n(\tO\nNSAIDs\tO\n)\tO\n.\tO\n\nWe\tO\nevaluated\tO\ncardiovascular\tO\nevent\tO\ndata\tO\nfor\tO\nvaldecoxib\tB-Chemical\n,\tO\na\tO\nnew\tO\nCOX\tO\n-\tO\n2\tO\n-\tO\nspecific\tO\ninhibitor\tO\nin\tO\napproximately\tO\n8000\tO\npatients\tO\nwith\tO\nosteoarthritis\tB-Disease\nand\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\ntreated\tO\nwith\tO\nthis\tO\nagent\tO\nin\tO\nrandomized\tO\nclinical\tO\ntrials\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ncardiovascular\tO\nthrombotic\tB-Disease\nevents\tO\n(\tO\ncardiac\tO\n,\tO\ncerebrovascular\tO\nand\tO\nperipheral\tO\nvascular\tO\n,\tO\nor\tO\narterial\tO\nthrombotic\tB-Disease\n)\tO\nwas\tO\ndetermined\tO\nby\tO\nanalyzing\tO\npooled\tO\nvaldecoxib\tB-Chemical\n(\tO\n10\tO\n-\tO\n80\tO\nmg\tO\ndaily\tO\n)\tO\n,\tO\nnonselective\tO\nNSAID\tO\n(\tO\ndiclofenac\tB-Chemical\n75\tO\nmg\tO\nbid\tO\n,\tO\nibuprofen\tB-Chemical\n800\tO\nmg\tO\ntid\tO\n,\tO\nor\tO\nnaproxen\tB-Chemical\n500\tO\nmg\tO\nbid\tO\n)\tO\nand\tO\nplacebo\tO\ndata\tO\nfrom\tO\n10\tO\nrandomized\tO\nosteoarthritis\tB-Disease\nand\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\ntrials\tO\nthat\tO\nwere\tO\n6\tO\n-\tO\n52\tO\nweeks\tO\nin\tO\nduration\tO\n.\tO\n\nThe\tO\nincidence\tO\nrates\tO\nof\tO\nevents\tO\nwere\tO\ndetermined\tO\nin\tO\nall\tO\npatients\tO\n(\tO\nn\tO\n=\tO\n7934\tO\n)\tO\nand\tO\nin\tO\nusers\tO\nof\tO\nlow\tO\n-\tO\ndose\tO\n(\tO\n<\tO\nor\tO\n=\tO\n325\tO\nmg\tO\ndaily\tO\n)\tO\naspirin\tB-Chemical\n(\tO\nn\tO\n=\tO\n1051\tO\n)\tO\nand\tO\nnonusers\tO\nof\tO\naspirin\tB-Chemical\n(\tO\nn\tO\n=\tO\n6883\tO\n)\tO\n.\tO\n\nCrude\tO\nand\tO\nexposure\tO\n-\tO\nadjusted\tO\nincidences\tO\nof\tO\nthrombotic\tB-Disease\nevents\tO\nwere\tO\nsimilar\tO\nfor\tO\nvaldecoxib\tB-Chemical\n,\tO\nNSAIDs\tO\n,\tO\nand\tO\nplacebo\tO\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nserious\tO\nthrombotic\tB-Disease\nevents\tO\nwas\tO\nalso\tO\nsimilar\tO\nfor\tO\neach\tO\nvaldecoxib\tB-Chemical\ndose\tO\n.\tO\n\nThrombotic\tB-Disease\nrisk\tO\nwas\tO\nconsistently\tO\nhigher\tO\nfor\tO\nusers\tO\nof\tO\naspirin\tB-Chemical\nusers\tO\nthan\tO\nnonusers\tO\nof\tO\naspirin\tB-Chemical\n(\tO\nplacebo\tO\n,\tO\n1\tO\n.\tO\n4\tO\n%\tO\nvs\tO\n.\tO\n0\tO\n%\tO\n;\tO\nvaldecoxib\tB-Chemical\n,\tO\n1\tO\n.\tO\n7\tO\n%\tO\nvs\tO\n.\tO\n0\tO\n.\tO\n2\tO\n%\tO\n;\tO\nNSAIDs\tO\n,\tO\n1\tO\n.\tO\n9\tO\n%\tO\nvs\tO\n.\tO\n0\tO\n.\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nrates\tO\nof\tO\nevents\tO\nin\tO\nusers\tO\nof\tO\naspirin\tB-Chemical\nwere\tO\nsimilar\tO\nfor\tO\nall\tO\n3\tO\ntreatment\tO\ngroups\tO\nand\tO\nacross\tO\nvaldecoxib\tB-Chemical\ndoses\tO\n.\tO\n\nShort\tO\n-\tO\nand\tO\nintermediate\tO\n-\tO\nterm\tO\ntreatment\tO\nwith\tO\ntherapeutic\tO\n(\tO\n10\tO\nor\tO\n20\tO\nmg\tO\ndaily\tO\n)\tO\nand\tO\nsupratherapeutic\tO\n(\tO\n40\tO\nor\tO\n80\tO\nmg\tO\ndaily\tO\n)\tO\nvaldecoxib\tB-Chemical\ndoses\tO\nwas\tO\nnot\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nincidence\tO\nof\tO\nthrombotic\tB-Disease\nevents\tO\nrelative\tO\nto\tO\nnonselective\tO\nNSAIDs\tO\nor\tO\nplacebo\tO\nin\tO\nosteoarthritis\tB-Disease\nand\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\npatients\tO\nin\tO\ncontrolled\tO\nclinical\tO\ntrials\tO\n.\tO\n\nHypersensitivity\tB-Disease\nmyocarditis\tB-Disease\ncomplicating\tO\nhypertrophic\tB-Disease\ncardiomyopathy\tI-Disease\nheart\tO\n.\tO\n\nThe\tO\npresent\tO\nreport\tO\ndescribes\tO\na\tO\ncase\tO\nof\tO\neosinophilic\tB-Disease\nmyocarditis\tI-Disease\ncomplicating\tO\nhypertrophic\tB-Disease\ncardiomyopathy\tI-Disease\n.\tO\n\nThe\tO\n47\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfemale\tO\npatient\tO\n,\tO\nknown\tO\nto\tO\nhave\tO\nhypertrophic\tB-Disease\ncardiomyopathy\tI-Disease\n,\tO\nwas\tO\nadmitted\tO\nwith\tO\nbiventricular\tB-Disease\nfailure\tI-Disease\nand\tO\nmanaged\tO\naggressively\tO\nwith\tO\ndobutamine\tB-Chemical\ninfusion\tO\nand\tO\nother\tO\ndrugs\tO\nwhile\tO\nbeing\tO\nassessed\tO\nfor\tO\nheart\tO\ntransplantation\tO\n.\tO\n\nOn\tO\ntransthoracic\tO\nechocardiogram\tO\n,\tO\nshe\tO\nhad\tO\nmoderate\tO\nleft\tB-Disease\nventricular\tI-Disease\ndysfunction\tI-Disease\nwith\tO\nregional\tO\nvariability\tO\nand\tO\nmoderate\tO\nmitral\tB-Disease\nregurgitation\tI-Disease\n.\tO\n\nThe\tO\nrecipient\tO\n'\tO\ns\tO\nheart\tO\nshowed\tO\nthe\tO\nfeatures\tO\nof\tO\napical\tO\nhypertrophic\tB-Disease\ncardiomyopathy\tI-Disease\nand\tO\nmyocarditis\tB-Disease\nwith\tO\nabundant\tO\neosinophils\tO\n.\tO\n\nMyocarditis\tB-Disease\nis\tO\nrare\tO\nand\tO\neosinophilic\tB-Disease\nmyocarditis\tI-Disease\nis\tO\nrarer\tO\n.\tO\n\nIt\tO\nis\tO\nlikely\tO\nthat\tO\nthe\tO\nhypersensitivity\tB-Disease\n(\tO\neosinophilic\tB-Disease\n)\tO\nmyocarditis\tB-Disease\nwas\tO\nrelated\tO\nto\tO\ndobutamine\tB-Chemical\ninfusion\tO\ntherapy\tO\n.\tO\n\nEosinophilic\tB-Disease\nmyocarditis\tI-Disease\nhas\tO\nbeen\tO\nreported\tO\nwith\tO\nan\tO\nincidence\tO\nof\tO\n2\tO\n.\tO\n4\tO\n%\tO\nto\tO\n7\tO\n.\tO\n2\tO\n%\tO\nin\tO\nexplanted\tO\nhearts\tO\nand\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nmultidrug\tO\ntherapy\tO\n.\tO\n\nTime\tO\ntrends\tO\nin\tO\nwarfarin\tB-Chemical\n-\tO\nassociated\tO\nhemorrhage\tB-Disease\n.\tO\n\nThe\tO\nannual\tO\nincidence\tO\nof\tO\nwarfarin\tB-Chemical\n-\tO\nrelated\tO\nbleeding\tB-Disease\nat\tO\nBrigham\tO\nand\tO\nWomen\tO\n'\tO\ns\tO\nHospital\tO\nincreased\tO\nfrom\tO\n0\tO\n.\tO\n97\tO\n/\tO\n1\tO\n,\tO\n000\tO\npatient\tO\nadmissions\tO\nin\tO\nthe\tO\nfirst\tO\ntime\tO\nperiod\tO\n(\tO\nJanuary\tO\n1995\tO\nto\tO\nOctober\tO\n1998\tO\n)\tO\nto\tO\n1\tO\n.\tO\n19\tO\n/\tO\n1\tO\n,\tO\n000\tO\npatient\tO\nadmissions\tO\nin\tO\nthe\tO\nsecond\tO\ntime\tO\nperiod\tO\n(\tO\nNovember\tO\n1998\tO\nto\tO\nAugust\tO\n2002\tO\n)\tO\nof\tO\nthis\tO\nstudy\tO\n.\tO\n\nThe\tO\nproportion\tO\nof\tO\npatients\tO\nwith\tO\nmajor\tO\nand\tO\nintracranial\tB-Disease\nbleeding\tI-Disease\nincreased\tO\nfrom\tO\n20\tO\n.\tO\n2\tO\n%\tO\nand\tO\n1\tO\n.\tO\n9\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nthe\tO\nfirst\tO\ntime\tO\nperiod\tO\n,\tO\nto\tO\n33\tO\n.\tO\n3\tO\n%\tO\nand\tO\n7\tO\n.\tO\n8\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nthe\tO\nsecond\tO\n.\tO\n\nYohimbine\tB-Chemical\ntreatment\tO\nof\tO\nsexual\tB-Disease\nside\tI-Disease\neffects\tI-Disease\ninduced\tO\nby\tO\nserotonin\tB-Chemical\nreuptake\tO\nblockers\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nPreclinical\tO\nand\tO\nclinical\tO\nstudies\tO\nsuggest\tO\nthat\tO\nyohimbine\tB-Chemical\nfacilitates\tO\nsexual\tO\nbehavior\tO\nand\tO\nmay\tO\nbe\tO\nhelpful\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nmale\tB-Disease\nimpotence\tI-Disease\n.\tO\n\nA\tO\nsingle\tO\ncase\tO\nreport\tO\nsuggests\tO\nthat\tO\nyohimbine\tB-Chemical\nmay\tO\nbe\tO\nused\tO\nto\tO\ntreat\tO\nthe\tO\nsexual\tB-Disease\nside\tI-Disease\neffects\tI-Disease\nof\tO\nclomipramine\tB-Chemical\n.\tO\n\nThis\tO\nstudy\tO\nevaluated\tO\nyohimbine\tB-Chemical\nas\tO\na\tO\ntreatment\tO\nfor\tO\nthe\tO\nsexual\tB-Disease\nside\tI-Disease\neffects\tI-Disease\ncaused\tO\nby\tO\nserotonin\tB-Chemical\nreuptake\tO\nblockers\tO\n.\tO\n\nMETHOD\tO\n:\tO\nSix\tO\npatients\tO\nwith\tO\neither\tO\nobsessive\tB-Disease\ncompulsive\tI-Disease\ndisorder\tI-Disease\n,\tO\ntrichotillomania\tB-Disease\n,\tO\nanxiety\tB-Disease\n,\tO\nor\tO\naffective\tB-Disease\ndisorders\tI-Disease\nwho\tO\nsuffered\tO\nsexual\tB-Disease\nside\tI-Disease\neffects\tI-Disease\nafter\tO\ntreatment\tO\nwith\tO\nserotonin\tB-Chemical\nreuptake\tO\nblockers\tO\nwere\tO\ngiven\tO\nyohimbine\tB-Chemical\non\tO\na\tO\np\tO\n.\tO\nr\tO\n.\tO\nn\tO\n.\tO\nbasis\tO\nin\tO\nan\tO\nopen\tO\nclinical\tO\ntrial\tO\n.\tO\n\nVarious\tO\ndoses\tO\nof\tO\nyohimbine\tB-Chemical\nwere\tO\nused\tO\nto\tO\ndetermine\tO\nthe\tO\nideal\tO\ndose\tO\nfor\tO\neach\tO\npatient\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFive\tO\nof\tO\nthe\tO\nsix\tO\npatients\tO\nexperienced\tO\nimproved\tO\nsexual\tO\nfunctioning\tO\nafter\tO\ntaking\tO\nyohimbine\tB-Chemical\n.\tO\n\nOne\tO\npatient\tO\nwho\tO\nfailed\tO\nto\tO\ncomply\tO\nwith\tO\nyohimbine\tB-Chemical\ntreatment\tO\nhad\tO\nno\tO\ntherapeutic\tO\neffects\tO\n.\tO\n\nSide\tO\neffects\tO\nof\tO\nyohimbine\tB-Chemical\nincluded\tO\nexcessive\tO\nsweating\tO\n,\tO\nincreased\tO\nanxiety\tB-Disease\n,\tO\nand\tO\na\tO\nwound\tO\n-\tO\nup\tO\nfeeling\tO\nin\tO\nsome\tO\npatients\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nresults\tO\nof\tO\nthis\tO\nstudy\tO\nindicate\tO\nthat\tO\nyohimbine\tB-Chemical\nmay\tO\nbe\tO\nan\tO\neffective\tO\ntreatment\tO\nfor\tO\nthe\tO\nsexual\tB-Disease\nside\tI-Disease\neffects\tI-Disease\ncaused\tO\nby\tO\nserotonin\tB-Chemical\nreuptake\tO\nblockers\tO\n.\tO\n\nFuture\tO\ncontrolled\tO\nstudies\tO\nare\tO\nneeded\tO\nto\tO\nfurther\tO\ninvestigate\tO\nthe\tO\neffectiveness\tO\nand\tO\nsafety\tO\nof\tO\nyohimbine\tB-Chemical\nfor\tO\nthis\tO\nindication\tO\n.\tO\n\nHemorrhagic\tB-Disease\ncystitis\tI-Disease\ncomplicating\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\n.\tO\n\nHemorrhagic\tB-Disease\ncystitis\tI-Disease\nis\tO\na\tO\npotentially\tO\nserious\tO\ncomplication\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\ncyclophosphamide\tB-Chemical\ntherapy\tO\nadministered\tO\nbefore\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\n.\tO\n\nAs\tO\nstandard\tO\npractice\tO\nat\tO\nour\tO\ninstitution\tO\n,\tO\npatients\tO\nwho\tO\nare\tO\nscheduled\tO\nto\tO\nreceive\tO\na\tO\nbone\tO\nmarrow\tO\ntransplant\tO\nare\tO\ntreated\tO\nprophylactically\tO\nwith\tO\nforced\tO\nhydration\tO\nand\tO\nbladder\tO\nirrigation\tO\n.\tO\n\nIn\tO\nan\tO\nattempt\tO\nto\tO\nobviate\tO\nthe\tO\ninconvenience\tO\nof\tO\nbladder\tO\nirrigation\tO\n,\tO\nwe\tO\nconducted\tO\na\tO\nfeasibility\tO\ntrial\tO\nof\tO\nuroprophylaxis\tO\nwith\tO\nmesna\tB-Chemical\n,\tO\nwhich\tO\nneutralizes\tO\nthe\tO\nhepatic\tO\nmetabolite\tO\nof\tO\ncyclophosphamide\tB-Chemical\nthat\tO\ncauses\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nOf\tO\n97\tO\npatients\tO\nwho\tO\nreceived\tO\nstandard\tO\nprophylaxis\tO\n,\tO\n4\tO\nhad\tO\nsymptomatic\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\ntwo\tO\nof\tO\nfour\tO\nconsecutive\tO\npatients\tO\nwho\tO\nreceived\tO\nmesna\tB-Chemical\nuroprophylaxis\tO\nbefore\tO\nallogeneic\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\nhad\tO\nsevere\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\nfor\tO\nat\tO\nleast\tO\n2\tO\nweeks\tO\n.\tO\n\nBecause\tO\nof\tO\nthis\tO\nsuboptimal\tO\nresult\tO\n,\tO\nwe\tO\nresumed\tO\nthe\tO\nuse\tO\nof\tO\nbladder\tO\nirrigation\tO\nand\tO\nforced\tO\nhydration\tO\nto\tO\nminimize\tO\nthe\tO\nrisk\tO\nof\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nConsensus\tO\nstatement\tO\nconcerning\tO\ncardiotoxicity\tB-Disease\noccurring\tO\nduring\tO\nhaematopoietic\tO\nstem\tO\ncell\tO\ntransplantation\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nautoimmune\tB-Disease\ndiseases\tI-Disease\n,\tO\nwith\tO\nspecial\tO\nreference\tO\nto\tO\nsystemic\tB-Disease\nsclerosis\tI-Disease\nand\tO\nmultiple\tB-Disease\nsclerosis\tI-Disease\n.\tO\n\nAutologous\tO\nhaematopoietic\tO\nstem\tO\ncell\tO\ntransplantation\tO\nis\tO\nnow\tO\na\tO\nfeasible\tO\nand\tO\neffective\tO\ntreatment\tO\nfor\tO\nselected\tO\npatients\tO\nwith\tO\nsevere\tO\nautoimmune\tB-Disease\ndiseases\tI-Disease\n.\tO\n\nWorldwide\tO\n,\tO\nover\tO\n650\tO\npatients\tO\nhave\tO\nbeen\tO\ntransplanted\tO\nin\tO\nthe\tO\ncontext\tO\nof\tO\nphase\tO\nI\tO\nand\tO\nII\tO\nclinical\tO\ntrials\tO\n.\tO\n\nThe\tO\nresults\tO\nare\tO\nencouraging\tO\nenough\tO\nto\tO\nbegin\tO\nrandomised\tO\nphase\tO\nIII\tO\ntrials\tO\n.\tO\n\nHowever\tO\n,\tO\nas\tO\npredicted\tO\n,\tO\nsignificant\tO\ntransplant\tO\n-\tO\nrelated\tO\nmorbidity\tO\nand\tO\nmortality\tO\nhave\tO\nbeen\tO\nobserved\tO\n.\tO\n\nThis\tO\nis\tO\nprimarily\tO\ndue\tO\nto\tO\ncomplications\tO\nrelated\tO\nto\tO\neither\tO\nthe\tO\nstage\tO\nof\tO\nthe\tO\ndisease\tO\nat\tO\ntransplant\tO\nor\tO\ndue\tO\nto\tO\ninfections\tB-Disease\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\ndeaths\tO\nrelated\tO\nto\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nis\tO\nlow\tO\n.\tO\n\nHowever\tO\n,\tO\ncaution\tO\nis\tO\nrequired\tO\nwhen\tO\ncyclophosphamide\tB-Chemical\nor\tO\nanthracyclines\tB-Chemical\nsuch\tO\nas\tO\nmitoxantrone\tB-Chemical\nare\tO\nused\tO\nin\tO\npatients\tO\nwith\tO\na\tO\npossible\tO\nunderlying\tO\nheart\tB-Disease\ndamage\tI-Disease\n,\tO\nfor\tO\nexample\tO\n,\tO\nsystemic\tB-Disease\nsclerosis\tI-Disease\npatients\tO\n.\tO\n\nIn\tO\nNovember\tO\n2002\tO\n,\tO\na\tO\nmeeting\tO\nwas\tO\nheld\tO\nin\tO\nFlorence\tO\n,\tO\nbringing\tO\ntogether\tO\na\tO\nnumber\tO\nof\tO\nexperts\tO\nin\tO\nvarious\tO\nfields\tO\n,\tO\nincluding\tO\nrheumatology\tO\n,\tO\ncardiology\tO\n,\tO\nneurology\tO\n,\tO\npharmacology\tO\nand\tO\ntransplantation\tO\nmedicine\tO\n.\tO\n\nThe\tO\nobject\tO\nof\tO\nthe\tO\nmeeting\tO\nwas\tO\nto\tO\nanalyse\tO\nexisting\tO\ndata\tO\n,\tO\nboth\tO\npublished\tO\nor\tO\navailable\tO\n,\tO\nin\tO\nthe\tO\nEuropean\tO\nGroup\tO\nfor\tO\nBlood\tO\nand\tO\nMarrow\tO\nTransplantation\tO\nautoimmune\tB-Disease\ndisease\tI-Disease\ndatabase\tO\n,\tO\nand\tO\nto\tO\npropose\tO\na\tO\nsafe\tO\napproach\tO\nto\tO\nsuch\tO\npatients\tO\n.\tO\n\nA\tO\nfull\tO\ncardiological\tO\nassessment\tO\nbefore\tO\nand\tO\nduring\tO\nthe\tO\ntransplant\tO\nemerged\tO\nas\tO\nthe\tO\nmajor\tO\nrecommendation\tO\n.\tO\n\nDoes\tO\nsupplemental\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nincrease\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\nrisk\tO\nin\tO\nwomen\tO\nwith\tO\ndiabetes\tB-Disease\n?\tO\n\nBACKGROUND\tO\n:\tO\nVitamin\tB-Chemical\nC\tI-Chemical\nacts\tO\nas\tO\na\tO\npotent\tO\nantioxidant\tO\n;\tO\nhowever\tO\n,\tO\nit\tO\ncan\tO\nalso\tO\nbe\tO\na\tO\nprooxidant\tO\nand\tO\nglycate\tO\nprotein\tO\nunder\tO\ncertain\tO\ncircumstances\tO\nin\tO\nvitro\tO\n.\tO\n\nThese\tO\nobservations\tO\nled\tO\nus\tO\nto\tO\nhypothesize\tO\nthat\tO\na\tO\nhigh\tO\nintake\tO\nof\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nin\tO\ndiabetic\tB-Disease\npersons\tO\nmight\tO\npromote\tO\natherosclerosis\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\nobjective\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\nrelation\tO\nbetween\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nintake\tO\nand\tO\nmortality\tO\nfrom\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n.\tO\n\nDESIGN\tO\n:\tO\nWe\tO\nstudied\tO\nthe\tO\nrelation\tO\nbetween\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nintake\tO\nand\tO\nmortality\tO\nfrom\tO\ntotal\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n(\tO\nn\tO\n=\tO\n281\tO\n)\tO\n,\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n(\tO\nn\tO\n=\tO\n175\tO\n)\tO\n,\tO\nand\tO\nstroke\tB-Disease\n(\tO\nn\tO\n=\tO\n57\tO\n)\tO\nin\tO\n1923\tO\npostmenopausal\tO\nwomen\tO\nwho\tO\nreported\tO\nbeing\tO\ndiabetic\tB-Disease\nat\tO\nbaseline\tO\n.\tO\n\nDiet\tO\nwas\tO\nassessed\tO\nwith\tO\na\tO\nfood\tO\n-\tO\nfrequency\tO\nquestionnaire\tO\nat\tO\nbaseline\tO\n,\tO\nand\tO\nsubjects\tO\ninitially\tO\nfree\tO\nof\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nwere\tO\nprospectively\tO\nfollowed\tO\nfor\tO\n15\tO\ny\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAfter\tO\nadjustment\tO\nfor\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\nrisk\tO\nfactors\tO\n,\tO\ntype\tO\nof\tO\ndiabetes\tB-Disease\nmedication\tO\nused\tO\n,\tO\nduration\tO\nof\tO\ndiabetes\tB-Disease\n,\tO\nand\tO\nintakes\tO\nof\tO\nfolate\tB-Chemical\n,\tO\nvitamin\tB-Chemical\nE\tI-Chemical\n,\tO\nand\tO\nbeta\tB-Chemical\n-\tI-Chemical\ncarotene\tI-Chemical\n,\tO\nthe\tO\nadjusted\tO\nrelative\tO\nrisks\tO\nof\tO\ntotal\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\nmortality\tO\nwere\tO\n1\tO\n.\tO\n0\tO\n,\tO\n0\tO\n.\tO\n97\tO\n,\tO\n1\tO\n.\tO\n11\tO\n,\tO\n1\tO\n.\tO\n47\tO\n,\tO\nand\tO\n1\tO\n.\tO\n84\tO\n(\tO\nP\tO\nfor\tO\ntrend\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nacross\tO\nquintiles\tO\nof\tO\ntotal\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nintake\tO\nfrom\tO\nfood\tO\nand\tO\nsupplements\tO\n.\tO\n\nAdjusted\tO\nrelative\tO\nrisks\tO\nof\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nwere\tO\n1\tO\n.\tO\n0\tO\n,\tO\n0\tO\n.\tO\n81\tO\n,\tO\n0\tO\n.\tO\n99\tO\n,\tO\n1\tO\n.\tO\n26\tO\n,\tO\nand\tO\n1\tO\n.\tO\n91\tO\n(\tO\nP\tO\nfor\tO\ntrend\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\nand\tO\nof\tO\nstroke\tB-Disease\nwere\tO\n1\tO\n.\tO\n0\tO\n,\tO\n0\tO\n.\tO\n52\tO\n,\tO\n1\tO\n.\tO\n23\tO\n,\tO\n2\tO\n.\tO\n22\tO\n,\tO\nand\tO\n2\tO\n.\tO\n57\tO\n(\tO\nP\tO\nfor\tO\ntrend\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nWhen\tO\ndietary\tO\nand\tO\nsupplemental\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nwere\tO\nanalyzed\tO\nseparately\tO\n,\tO\nonly\tO\nsupplemental\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nshowed\tO\na\tO\npositive\tO\nassociation\tO\nwith\tO\nmortality\tO\nendpoints\tO\n.\tO\n\nVitamin\tB-Chemical\nC\tI-Chemical\nintake\tO\nwas\tO\nunrelated\tO\nto\tO\nmortality\tO\nfrom\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\nin\tO\nthe\tO\nnondiabetic\tO\nsubjects\tO\nat\tO\nbaseline\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nA\tO\nhigh\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nintake\tO\nfrom\tO\nsupplements\tO\nis\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\nmortality\tO\nin\tO\npostmenopausal\tO\nwomen\tO\nwith\tO\ndiabetes\tB-Disease\n.\tO\n\nOptical\tO\ncoherence\tO\ntomography\tO\ncan\tO\nmeasure\tO\naxonal\tO\nloss\tO\nin\tO\npatients\tO\nwith\tO\nethambutol\tB-Chemical\n-\tO\ninduced\tO\noptic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nmap\tO\nand\tO\nidentify\tO\nthe\tO\npattern\tO\n,\tO\nin\tO\nvivo\tO\n,\tO\nof\tO\naxonal\tB-Disease\ndegeneration\tI-Disease\nin\tO\nethambutol\tB-Chemical\n-\tO\ninduced\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nusing\tO\noptical\tO\ncoherence\tO\ntomography\tO\n(\tO\nOCT\tO\n)\tO\n.\tO\n\nEthambutol\tB-Chemical\nis\tO\nan\tO\nantimycobacterial\tO\nagent\tO\noften\tO\nused\tO\nto\tO\ntreat\tO\ntuberculosis\tB-Disease\n.\tO\n\nA\tO\nserious\tO\ncomplication\tO\nof\tO\nethambutol\tB-Chemical\nis\tO\nan\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nthat\tO\nimpairs\tO\nvisual\tO\nacuity\tO\n,\tO\ncontrast\tO\nsensitivity\tO\n,\tO\nand\tO\ncolor\tO\nvision\tO\n.\tO\n\nHowever\tO\n,\tO\nearly\tO\non\tO\n,\tO\nwhen\tO\nthe\tO\ntoxic\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nis\tO\nmild\tO\nand\tO\npartly\tO\nreversible\tO\n,\tO\nthe\tO\nfunduscopic\tO\nfindings\tO\nare\tO\noften\tO\nsubtle\tO\nand\tO\neasy\tO\nto\tO\nmiss\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThree\tO\nsubjects\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nethambutol\tB-Chemical\n(\tO\nEMB\tB-Chemical\n)\tO\n-\tO\ninduced\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nof\tO\nshort\tO\n-\tO\n,\tO\nintermediate\tO\n-\tO\n,\tO\nand\tO\nlong\tO\n-\tO\nterm\tO\nvisual\tB-Disease\ndeficits\tI-Disease\nwere\tO\nadministered\tO\na\tO\nfull\tO\nneuro\tO\n-\tO\nophthalmologic\tO\nexamination\tO\nincluding\tO\nvisual\tO\nacuity\tO\n,\tO\ncolor\tO\nvision\tO\n,\tO\ncontrast\tO\nsensitivity\tO\n,\tO\nand\tO\nfundus\tO\nexamination\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nOCT\tO\n(\tO\nOCT\tO\n3000\tO\n,\tO\nHumphrey\tO\n-\tO\nZeiss\tO\n,\tO\nDublin\tO\n,\tO\nCA\tO\n)\tO\nwas\tO\nperformed\tO\non\tO\nboth\tO\neyes\tO\nof\tO\neach\tO\nsubject\tO\nusing\tO\nthe\tO\nretinal\tO\nnerve\tO\nfiber\tO\nlayer\tO\n(\tO\nRNFL\tO\n)\tO\nanalysis\tO\nprotocol\tO\n.\tO\n\nOCT\tO\ninterpolates\tO\ndata\tO\nfrom\tO\n100\tO\npoints\tO\naround\tO\nthe\tO\noptic\tO\nnerve\tO\nto\tO\neffectively\tO\nmap\tO\nout\tO\nthe\tO\nRNFL\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nresults\tO\nwere\tO\ncompared\tO\nto\tO\nthe\tO\ncalculated\tO\naverage\tO\nRNFL\tO\nof\tO\nnormal\tO\neyes\tO\naccumulated\tO\nfrom\tO\nfour\tO\nprior\tO\nstudies\tO\nusing\tO\nOCT\tO\n,\tO\nn\tO\n=\tO\n661\tO\n.\tO\n\nIn\tO\nall\tO\nsubjects\tO\nwith\tO\nhistory\tO\nof\tO\nEMB\tB-Chemical\n-\tO\ninduced\tO\noptic\tB-Disease\nneuropathy\tI-Disease\n,\tO\nthere\tO\nwas\tO\na\tO\nmean\tO\nloss\tO\nof\tO\n72\tO\n%\tO\nnerve\tO\nfiber\tO\nlayer\tO\nthickness\tO\nin\tO\nthe\tO\ntemporal\tO\nquadrant\tO\n(\tO\npatient\tO\nA\tO\n,\tO\nwith\tO\neventual\tO\nrecovery\tO\nof\tO\nvisual\tO\nacuity\tO\nand\tO\nfields\tO\n,\tO\n58\tO\n%\tO\nloss\tO\n;\tO\npatient\tO\nB\tO\n,\tO\nwith\tO\nintermediate\tO\nvisual\tB-Disease\ndeficits\tI-Disease\n,\tO\n68\tO\n%\tO\nloss\tO\n;\tO\npatient\tO\nC\tO\n,\tO\nwith\tO\nchronic\tO\nvisual\tB-Disease\ndeficits\tI-Disease\n,\tO\n90\tO\n%\tO\nloss\tO\n)\tO\n,\tO\nwith\tO\nan\tO\naverage\tO\nmean\tO\noptic\tO\nnerve\tO\nthickness\tO\nof\tO\n26\tO\n+\tO\n/\tO\n-\tO\n16\tO\nmicrom\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\ncombined\tO\nmean\tO\nloss\tO\nof\tO\n46\tO\n%\tO\nof\tO\nfibers\tO\nfrom\tO\nthe\tO\nsuperior\tO\n,\tO\ninferior\tO\n,\tO\nand\tO\nnasal\tO\nquadrants\tO\nin\tO\nthe\tO\n(\tO\nsix\tO\n)\tO\neyes\tO\nof\tO\nall\tO\nthree\tO\nsubjects\tO\n(\tO\nmean\tO\naverage\tO\nthickness\tO\nof\tO\n55\tO\n+\tO\n/\tO\n-\tO\n29\tO\nmicrom\tO\n)\tO\n.\tO\n\nIn\tO\nboth\tO\nsets\tO\n(\tO\nfour\tO\n)\tO\nof\tO\neyes\tO\nof\tO\nthe\tO\nsubjects\tO\nwith\tO\npersistent\tO\nvisual\tB-Disease\ndeficits\tI-Disease\n(\tO\npatients\tO\nB\tO\nand\tO\nC\tO\n)\tO\n,\tO\nthere\tO\nwas\tO\nan\tO\naverage\tO\nloss\tO\nof\tO\n79\tO\n%\tO\nof\tO\nnerve\tO\nfiber\tO\nthickness\tO\nin\tO\nthe\tO\ntemporal\tO\nquadrant\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nOCT\tO\nresults\tO\nin\tO\nthese\tO\npatients\tO\nwith\tO\nEMB\tB-Chemical\n-\tO\ninduced\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nshow\tO\nconsiderable\tO\nloss\tO\nespecially\tO\nof\tO\nthe\tO\ntemporal\tO\nfibers\tO\n.\tO\n\nThis\tO\nis\tO\nconsistent\tO\nwith\tO\nprior\tO\nhistopathological\tO\nstudies\tO\nthat\tO\nshow\tO\npredominant\tO\nloss\tO\nof\tO\nparvo\tO\n-\tO\ncellular\tO\naxons\tO\n(\tO\nor\tO\nsmall\tO\n-\tO\ncaliber\tO\naxons\tO\n)\tO\nwithin\tO\nthe\tO\npapillo\tO\n-\tO\nmacular\tO\nbundle\tO\nin\tO\ntoxic\tO\nor\tO\nhereditary\tO\noptic\tB-Disease\nneuropathies\tI-Disease\n.\tO\n\nOCT\tO\ncan\tO\nbe\tO\na\tO\nvaluable\tO\ntool\tO\nin\tO\nthe\tO\nquantitative\tO\nanalysis\tO\nof\tO\noptic\tB-Disease\nneuropathies\tI-Disease\n.\tO\n\nAdditionally\tO\n,\tO\nin\tO\nterms\tO\nof\tO\nmanagement\tO\nof\tO\nEMB\tB-Chemical\n-\tO\ninduced\tO\noptic\tB-Disease\nneuropathy\tI-Disease\n,\tO\nit\tO\nis\tO\nimportant\tO\nto\tO\nproperly\tO\nmanage\tO\nethambutol\tB-Chemical\ndosing\tO\nin\tO\npatients\tO\nwith\tO\nrenal\tB-Disease\nimpairment\tI-Disease\nand\tO\nto\tO\nachieve\tO\nproper\tO\ntransition\tO\nto\tO\na\tO\nmaintenance\tO\ndose\tO\nonce\tO\nan\tO\nappropriate\tO\nloading\tO\ndose\tO\nhas\tO\nbeen\tO\nreached\tO\n.\tO\n\nHypoxia\tB-Disease\nin\tO\nrenal\tB-Disease\ndisease\tI-Disease\nwith\tO\nproteinuria\tB-Disease\nand\tO\n/\tO\nor\tO\nglomerular\tO\nhypertension\tB-Disease\n.\tO\n\nDespite\tO\nthe\tO\nincreasing\tO\nneed\tO\nto\tO\nidentify\tO\nand\tO\nquantify\tO\ntissue\tO\noxygenation\tO\nat\tO\nthe\tO\ncellular\tO\nlevel\tO\n,\tO\nrelatively\tO\nfew\tO\nmethods\tO\nhave\tO\nbeen\tO\navailable\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\ndeveloped\tO\na\tO\nnew\tO\nhypoxia\tB-Disease\n-\tO\nresponsive\tO\nreporter\tO\nvector\tO\nusing\tO\na\tO\nhypoxia\tB-Disease\n-\tO\nresponsive\tO\nelement\tO\nof\tO\nthe\tO\n5\tO\n'\tO\nvascular\tO\nendothelial\tO\ngrowth\tO\nfactor\tO\nuntranslated\tO\nregion\tO\nand\tO\ngenerated\tO\na\tO\nnovel\tO\nhypoxia\tB-Disease\n-\tO\nsensing\tO\ntransgenic\tO\nrat\tO\n.\tO\n\nWe\tO\nthen\tO\napplied\tO\nthis\tO\nanimal\tO\nmodel\tO\nto\tO\nthe\tO\ndetection\tO\nof\tO\ntubulointerstitial\tO\nhypoxia\tB-Disease\nin\tO\nthe\tO\ndiseased\tB-Disease\nkidney\tI-Disease\n.\tO\n\nWith\tO\nthis\tO\nmodel\tO\n,\tO\nwe\tO\nwere\tO\nable\tO\nto\tO\nidentify\tO\ndiffuse\tO\ncortical\tO\nhypoxia\tB-Disease\nin\tO\nthe\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\nand\tO\nfocal\tO\nand\tO\nsegmental\tO\nhypoxia\tB-Disease\nin\tO\nthe\tO\nremnant\tO\nkidney\tO\nmodel\tO\n.\tO\n\nExpression\tO\nof\tO\nthe\tO\nhypoxia\tB-Disease\n-\tO\nresponsive\tO\ntransgene\tO\nincreased\tO\nthroughout\tO\nthe\tO\nobservation\tO\nperiod\tO\n,\tO\nreaching\tO\n2\tO\n.\tO\n2\tO\n-\tO\nfold\tO\nat\tO\n2\tO\nweeks\tO\nin\tO\nthe\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nmodel\tO\nand\tO\n2\tO\n.\tO\n6\tO\n-\tO\nfold\tO\nat\tO\n4\tO\nweeks\tO\nin\tO\nthe\tO\nremnant\tO\nkidney\tO\nmodel\tO\n,\tO\nwhereas\tO\nthat\tO\nof\tO\nvascular\tO\nendothelial\tO\ngrowth\tO\nfactor\tO\nshowed\tO\na\tO\nmild\tO\ndecrease\tO\n,\tO\nreflecting\tO\ndistinct\tO\nbehaviors\tO\nof\tO\nthe\tO\ntwo\tO\ngenes\tO\n.\tO\n\nThe\tO\ndegree\tO\nof\tO\nhypoxia\tB-Disease\nshowed\tO\na\tO\npositive\tO\ncorrelation\tO\nwith\tO\nmicroscopic\tO\ntubulointerstitial\tB-Disease\ninjury\tI-Disease\nin\tO\nboth\tO\nmodels\tO\n.\tO\n\nFinally\tO\n,\tO\nwe\tO\nidentified\tO\nthe\tO\nlocalization\tO\nof\tO\nproliferating\tO\ncell\tO\nnuclear\tO\nantigen\tO\n-\tO\npositive\tO\n,\tO\nED\tO\n-\tO\n1\tO\n-\tO\npositive\tO\n,\tO\nand\tO\nterminal\tO\ndUTP\tO\nnick\tO\n-\tO\nend\tO\nlabeled\tO\n-\tO\npositive\tO\ncells\tO\nin\tO\nthe\tO\nhypoxic\tB-Disease\ncortical\tO\narea\tO\nin\tO\nthe\tO\nremnant\tO\nkidney\tO\nmodel\tO\n.\tO\n\nWe\tO\npropose\tO\nhere\tO\na\tO\npossible\tO\npathological\tO\ntie\tO\nbetween\tO\nchronic\tO\ntubulointerstitial\tO\nhypoxia\tB-Disease\nand\tO\nprogressive\tO\nglomerular\tB-Disease\ndiseases\tI-Disease\n.\tO\n\nAdequate\tO\ntiming\tO\nof\tO\nribavirin\tB-Chemical\nreduction\tO\nin\tO\npatients\tO\nwith\tO\nhemolysis\tB-Disease\nduring\tO\ncombination\tO\ntherapy\tO\nof\tO\ninterferon\tB-Chemical\nand\tO\nribavirin\tB-Chemical\nfor\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nC\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nHemolytic\tB-Disease\nanemia\tI-Disease\nis\tO\none\tO\nof\tO\nthe\tO\nmajor\tO\nadverse\tO\nevents\tO\nof\tO\nthe\tO\ncombination\tO\ntherapy\tO\nof\tO\ninterferon\tB-Chemical\nand\tO\nribavirin\tB-Chemical\n.\tO\n\nBecause\tO\nof\tO\nribavirin\tB-Chemical\n-\tO\nrelated\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n,\tO\ndose\tO\nreduction\tO\nis\tO\na\tO\ncommon\tO\nevent\tO\nin\tO\nthis\tO\ntherapy\tO\n.\tO\n\nIn\tO\nthis\tO\nclinical\tO\nretrospective\tO\ncohort\tO\nstudy\tO\nwe\tO\nhave\tO\nexamined\tO\nthe\tO\nsuitable\tO\ntiming\tO\nof\tO\nribavirin\tB-Chemical\nreduction\tO\nin\tO\npatients\tO\nwith\tO\nhemolysis\tB-Disease\nduring\tO\ncombination\tO\ntherapy\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThirty\tO\n-\tO\nseven\tO\nof\tO\n160\tO\npatients\tO\nwho\tO\nhad\tO\nHCV\tO\n-\tO\ngenotype\tO\n1b\tO\n,\tO\nhad\tO\nhigh\tO\nvirus\tO\nload\tO\n,\tO\nand\tO\nreceived\tO\n24\tO\n-\tO\nweek\tO\ncombination\tO\ntherapy\tO\ndeveloped\tO\nanemia\tB-Disease\nwith\tO\nhemoglobin\tO\nlevel\tO\n<\tO\n10\tO\ng\tO\n/\tO\ndl\tO\nor\tO\nanemia\tB-Disease\n-\tO\nrelated\tO\nsigns\tO\nduring\tO\ntherapy\tO\n.\tO\n\nAfter\tO\nthat\tO\n,\tO\nthese\tO\n37\tO\npatients\tO\nwere\tO\nreduced\tO\none\tO\ntablet\tO\nof\tO\nribavirin\tB-Chemical\n(\tO\n200\tO\nmg\tO\n)\tO\nper\tO\nday\tO\n.\tO\n\nAfter\tO\nreduction\tO\nof\tO\nribavirin\tB-Chemical\n,\tO\n27\tO\nof\tO\n37\tO\npatients\tO\ncould\tO\ncontinue\tO\ncombination\tO\ntherapy\tO\nfor\tO\na\tO\ntotal\tO\nof\tO\n24\tO\nweeks\tO\n(\tO\ngroup\tO\nA\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\n10\tO\nof\tO\n37\tO\npatients\tO\nwith\tO\nreduction\tO\nof\tO\nribavirin\tB-Chemical\ncould\tO\nnot\tO\ncontinue\tO\ncombination\tO\ntherapy\tO\nbecause\tO\ntheir\tO\n<\tO\n8\tO\n.\tO\n5\tO\ng\tO\n/\tO\ndl\tO\nhemoglobin\tO\nvalues\tO\ndecreased\tO\nto\tO\nor\tO\nanemia\tB-Disease\n-\tO\nrelated\tO\nsevere\tO\nside\tO\neffects\tO\noccurred\tO\n(\tO\ngroup\tO\nB\tO\n)\tO\n.\tO\n\nWe\tO\nassessed\tO\nthe\tO\nfinal\tO\nefficacy\tO\nand\tO\nsafety\tO\nafter\tO\nreduction\tO\nof\tO\nribavirin\tB-Chemical\nin\tO\ngroups\tO\nA\tO\nand\tO\nB\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\nsustained\tO\nvirological\tO\nresponse\tO\n(\tO\nSVR\tO\n)\tO\nwas\tO\n29\tO\n.\tO\n6\tO\n%\tO\n(\tO\n8\tO\n/\tO\n27\tO\n)\tO\nin\tO\ngroup\tO\nA\tO\nand\tO\n10\tO\n%\tO\n(\tO\n1\tO\n/\tO\n10\tO\n)\tO\nin\tO\ngroup\tO\nB\tO\n,\tO\nrespectively\tO\n.\tO\n\nA\tO\n34\tO\n.\tO\n4\tO\n%\tO\n(\tO\n12\tO\n/\tO\n27\tO\n)\tO\nof\tO\nSVR\tO\n+\tO\nbiological\tO\nresponse\tO\nin\tO\ngroup\tO\nA\tO\nwas\tO\nhigher\tO\nthan\tO\n10\tO\n%\tO\n(\tO\n1\tO\n/\tO\n10\tO\n)\tO\nin\tO\ngroup\tO\nB\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n051\tO\n)\tO\n,\tO\nwith\tO\nslight\tO\nsignificance\tO\n.\tO\n\nWith\tO\nrespect\tO\nto\tO\nhemoglobin\tO\nlevel\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\nribavirin\tB-Chemical\nreduction\tO\n,\tO\na\tO\nrate\tO\nof\tO\ncontinuation\tO\nof\tO\ntherapy\tO\nin\tO\npatients\tO\nwith\tO\n>\tO\nor\tO\n=\tO\n10\tO\ng\tO\n/\tO\ndl\tO\nhemoglobin\tO\nwas\tO\nhigher\tO\nthan\tO\nthat\tO\nin\tO\npatients\tO\nwith\tO\n<\tO\n10\tO\ng\tO\n/\tO\ndl\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n036\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nReduction\tO\nof\tO\nribavirin\tB-Chemical\nat\tO\nhemoglobin\tO\nlevel\tO\n>\tO\nor\tO\n=\tO\n10\tO\ng\tO\n/\tO\ndl\tO\nis\tO\nsuitable\tO\nin\tO\nterms\tO\nof\tO\nefficacy\tO\nand\tO\nside\tO\neffects\tO\n.\tO\n\nAging\tO\nprocess\tO\nof\tO\nepithelial\tO\ncells\tO\nof\tO\nthe\tO\nrat\tO\nprostate\tO\nlateral\tO\nlobe\tO\nin\tO\nexperimental\tO\nhyperprolactinemia\tB-Disease\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\ninfluence\tO\nof\tO\nhyperprolactinemia\tB-Disease\n,\tO\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\n(\tO\nHAL\tB-Chemical\n)\tO\non\tO\nage\tO\nrelated\tO\nmorphology\tO\nand\tO\nfunction\tO\nchanges\tO\nof\tO\nepithelial\tO\ncells\tO\nin\tO\nrat\tO\nprostate\tO\nlateral\tO\nlobe\tO\n.\tO\n\nThe\tO\nstudy\tO\nwas\tO\nperformed\tO\non\tO\nsexually\tO\nmature\tO\nmale\tO\nrats\tO\n.\tO\n\nSerum\tO\nconcentrations\tO\nof\tO\nprolactin\tO\n(\tO\nPRL\tB-Chemical\n)\tO\nand\tO\ntestosterone\tB-Chemical\n(\tO\nT\tB-Chemical\n)\tO\nwere\tO\nmeasured\tO\n.\tO\n\nTissue\tO\nsections\tO\nwere\tO\nevaluated\tO\nwith\tO\nlight\tO\nand\tO\nelectron\tO\nmicroscopy\tO\n.\tO\n\nImmunohistochemical\tO\nreactions\tO\nfor\tO\nAnti\tO\n-\tO\nProliferating\tO\nCell\tO\nNuclear\tO\nAntigen\tO\n(\tO\nPCNA\tO\n)\tO\nwere\tO\nperformed\tO\n.\tO\n\nIn\tO\nrats\tO\nof\tO\nthe\tO\nexperimental\tO\ngroup\tO\n,\tO\nthe\tO\nmean\tO\nconcentration\tO\nof\tO\n:\tO\nPRL\tB-Chemical\nwas\tO\nmore\tO\nthan\tO\ntwice\tO\nhigher\tO\n,\tO\nwhereas\tO\nT\tB-Chemical\nconcentration\tO\nwas\tO\nalmost\tO\ntwice\tO\nlower\tO\nthan\tO\nthat\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nLight\tO\nmicroscopy\tO\nvisualized\tO\nthe\tO\nfollowing\tO\n:\tO\nhypertrophy\tB-Disease\nand\tO\nepithelium\tO\nhyperplasia\tB-Disease\nof\tO\nthe\tO\nglandular\tO\nducts\tO\n,\tO\nassociated\tO\nwith\tO\nincreased\tO\nPCNA\tO\nexpression\tO\n.\tO\n\nElectron\tO\nmicroscopy\tO\nrevealed\tO\nchanges\tO\nin\tO\ncolumnar\tO\nepithelial\tO\ncells\tO\n,\tO\nconcerning\tO\norganelles\tO\n,\tO\nengaged\tO\nin\tO\nprotein\tO\nsynthesis\tO\nand\tO\nsecretion\tO\n.\tO\n\nRelation\tO\nof\tO\nperfusion\tO\ndefects\tO\nobserved\tO\nwith\tO\nmyocardial\tO\ncontrast\tO\nechocardiography\tO\nto\tO\nthe\tO\nseverity\tO\nof\tO\ncoronary\tB-Disease\nstenosis\tI-Disease\n:\tO\ncorrelation\tO\nwith\tO\nthallium\tB-Chemical\n-\tO\n201\tO\nsingle\tO\n-\tO\nphoton\tO\nemission\tO\ntomography\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\npreviously\tO\nshown\tO\nthat\tO\nmyocardial\tO\ncontrast\tO\nechocardiography\tO\nis\tO\na\tO\nvaluable\tO\ntechnique\tO\nfor\tO\ndelineating\tO\nregions\tO\nof\tO\nmyocardial\tO\nunderperfusion\tO\nsecondary\tO\nto\tO\ncoronary\tB-Disease\nocclusion\tI-Disease\nand\tO\nto\tO\ncritical\tO\ncoronary\tB-Disease\nstenoses\tI-Disease\nin\tO\nthe\tO\npresence\tO\nof\tO\nhyperemic\tB-Disease\nstimulation\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nwhether\tO\nmyocardial\tO\ncontrast\tO\nechocardiography\tO\nperformed\tO\nwith\tO\na\tO\nstable\tO\nsolution\tO\nof\tO\nsonicated\tO\nalbumin\tO\ncould\tO\ndetect\tO\nregions\tO\nof\tO\nmyocardial\tO\nunderperfusion\tO\nresulting\tO\nfrom\tO\nvarious\tO\ndegrees\tO\nof\tO\ncoronary\tB-Disease\nstenosis\tI-Disease\n.\tO\n\nThe\tO\nperfusion\tO\ndefect\tO\nproduced\tO\nin\tO\n16\tO\nopen\tO\nchest\tO\ndogs\tO\nwas\tO\ncompared\tO\nwith\tO\nthe\tO\nanatomic\tO\narea\tO\nat\tO\nrisk\tO\nmeasured\tO\nby\tO\nthe\tO\npostmortem\tO\ndual\tO\n-\tO\nperfusion\tO\ntechnique\tO\nand\tO\nwith\tO\nthallium\tB-Chemical\n-\tO\n201\tO\nsingle\tO\n-\tO\nphoton\tO\nemission\tO\ntomography\tO\n(\tO\nSPECT\tO\n)\tO\n.\tO\n\nDuring\tO\na\tO\ntransient\tO\n(\tO\n20\tO\n-\tO\ns\tO\n)\tO\ncoronary\tB-Disease\nocclusion\tI-Disease\n,\tO\na\tO\nperfusion\tO\ndefect\tO\nwas\tO\nobserved\tO\nwith\tO\ncontrast\tO\nechocardiography\tO\nin\tO\n14\tO\nof\tO\nthe\tO\n15\tO\ndogs\tO\nin\tO\nwhich\tO\nthe\tO\nocclusion\tO\nwas\tO\nproduced\tO\n.\tO\n\nThe\tO\nperfusion\tO\ndefect\tO\ncorrelated\tO\nsignificantly\tO\nwith\tO\nthe\tO\nanatomic\tO\narea\tO\nat\tO\nrisk\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n74\tO\n;\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nDuring\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\nhyperemia\tB-Disease\n,\tO\n12\tO\nof\tO\nthe\tO\n16\tO\ndogs\tO\nwith\tO\na\tO\npartial\tO\ncoronary\tB-Disease\nstenosis\tI-Disease\nhad\tO\na\tO\nvisible\tO\narea\tO\nof\tO\nhypoperfusion\tO\nby\tO\ncontrast\tO\nechocardiography\tO\n.\tO\n\nThe\tO\nfour\tO\ndogs\tO\nwithout\tO\na\tO\nperfusion\tO\ndefect\tO\nhad\tO\na\tO\nstenosis\tO\nthat\tO\nresulted\tO\nin\tO\na\tO\nmild\tO\n(\tO\n0\tO\n%\tO\nto\tO\n50\tO\n%\tO\n)\tO\nreduction\tO\nin\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\nhyperemia\tB-Disease\n.\tO\n\nThe\tO\nsize\tO\nof\tO\nthe\tO\nperfusion\tO\ndefect\tO\nduring\tO\nstenosis\tO\ncorrelated\tO\nsignificantly\tO\nwith\tO\nthe\tO\nanatomic\tO\narea\tO\nat\tO\nrisk\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n61\tO\n;\tO\np\tO\n=\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nThallium\tB-Chemical\n-\tO\n201\tO\nSPECT\tO\ndemonstrated\tO\na\tO\nperfusion\tO\ndefect\tO\nin\tO\nall\tO\n14\tO\ndogs\tO\nanalyzed\tO\nduring\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\nhyperemia\tB-Disease\n;\tO\nthe\tO\nsize\tO\nof\tO\nthe\tO\nperfusion\tO\ndefect\tO\ncorrelated\tO\nwith\tO\nthe\tO\nanatomic\tO\narea\tO\nat\tO\nrisk\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n58\tO\n;\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n03\tO\n)\tO\nand\tO\nwith\tO\nthe\tO\nperfusion\tO\ndefect\tO\nby\tO\ncontrast\tO\nechocardiography\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n58\tO\n;\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n03\tO\n)\tO\n.\tO\n\nThus\tO\n,\tO\nmyocardial\tO\ncontrast\tO\nechocardiography\tO\ncan\tO\nbe\tO\nused\tO\nto\tO\nvisualize\tO\nand\tO\nquantitate\tO\nthe\tO\namount\tO\nof\tO\njeopardized\tO\nmyocardium\tO\nduring\tO\nmoderate\tO\nto\tO\nsevere\tO\ndegrees\tO\nof\tO\ncoronary\tB-Disease\nstenosis\tI-Disease\n.\tO\n\nThe\tO\nresults\tO\nobtained\tO\nshow\tO\na\tO\ncorrelation\tO\nwith\tO\nthe\tO\nanatomic\tO\narea\tO\nat\tO\nrisk\tO\nsimilar\tO\nto\tO\nthat\tO\nobtained\tO\nwith\tO\nthallium\tB-Chemical\n-\tO\n201\tO\nSPECT\tO\n.\tO\n\nThe\tO\nactivation\tO\nof\tO\nspinal\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\nreceptors\tO\nmay\tO\ncontribute\tO\nto\tO\ndegeneration\tO\nof\tO\nspinal\tO\nmotor\tO\nneurons\tO\ninduced\tO\nby\tO\nneuraxial\tO\nmorphine\tB-Chemical\nafter\tO\na\tO\nnoninjurious\tO\ninterval\tO\nof\tO\nspinal\tB-Disease\ncord\tI-Disease\nischemia\tI-Disease\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\nrelationship\tO\nbetween\tO\nthe\tO\ndegeneration\tO\nof\tO\nspinal\tO\nmotor\tO\nneurons\tO\nand\tO\nactivation\tO\nof\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nd\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nreceptors\tO\nafter\tO\nneuraxial\tO\nmorphine\tB-Chemical\nfollowing\tO\na\tO\nnoninjurious\tO\ninterval\tO\nof\tO\naortic\tB-Disease\nocclusion\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nSpinal\tB-Disease\ncord\tI-Disease\nischemia\tI-Disease\nwas\tO\ninduced\tO\nby\tO\naortic\tB-Disease\nocclusion\tI-Disease\nfor\tO\n6\tO\nmin\tO\nwith\tO\na\tO\nballoon\tO\ncatheter\tO\n.\tO\n\nIn\tO\na\tO\nmicrodialysis\tO\nstudy\tO\n,\tO\n10\tO\nmuL\tO\nof\tO\nsaline\tO\n(\tO\ngroup\tO\nC\tO\n;\tO\nn\tO\n=\tO\n8\tO\n)\tO\nor\tO\n30\tO\nmug\tO\nof\tO\nmorphine\tB-Chemical\n(\tO\ngroup\tO\nM\tO\n;\tO\nn\tO\n=\tO\n8\tO\n)\tO\nwas\tO\ninjected\tO\nintrathecally\tO\n(\tO\nIT\tO\n)\tO\n0\tO\n.\tO\n5\tO\nh\tO\nafter\tO\nreflow\tO\n,\tO\nand\tO\n30\tO\nmug\tO\nof\tO\nmorphine\tB-Chemical\n(\tO\ngroup\tO\nSM\tO\n;\tO\nn\tO\n=\tO\n8\tO\n)\tO\nor\tO\n10\tO\nmuL\tO\nof\tO\nsaline\tO\n(\tO\ngroup\tO\nSC\tO\n;\tO\nn\tO\n=\tO\n8\tO\n)\tO\nwas\tO\ninjected\tO\nIT\tO\n0\tO\n.\tO\n5\tO\nh\tO\nafter\tO\nsham\tO\noperation\tO\n.\tO\n\nMicrodialysis\tO\nsamples\tO\nwere\tO\ncollected\tO\npreischemia\tO\n,\tO\nbefore\tO\nIT\tO\ninjection\tO\n,\tO\nand\tO\nat\tO\n2\tO\n,\tO\n4\tO\n,\tO\n8\tO\n,\tO\n24\tO\n,\tO\nand\tO\n48\tO\nh\tO\nof\tO\nreperfusion\tO\n(\tO\nafter\tO\nIT\tO\ninjection\tO\n)\tO\n.\tO\n\nSecond\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\neffect\tO\nof\tO\nIT\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n(\tO\n30\tO\nmug\tO\n)\tO\non\tO\nthe\tO\nhistopathologic\tO\nchanges\tO\nin\tO\nthe\tO\nspinal\tO\ncord\tO\nafter\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nspastic\tB-Disease\nparaparesis\tI-Disease\n.\tO\n\nAfter\tO\nIT\tO\nmorphine\tB-Chemical\n,\tO\nthe\tO\ncerebrospinal\tO\nfluid\tO\n(\tO\nCSF\tO\n)\tO\nglutamate\tB-Chemical\nconcentration\tO\nwas\tO\nincreased\tO\nin\tO\ngroup\tO\nM\tO\nrelative\tO\nto\tO\nboth\tO\nbaseline\tO\nand\tO\ngroup\tO\nC\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThis\tO\nincrease\tO\npersisted\tO\nfor\tO\n8\tO\nhrs\tO\n.\tO\n\nIT\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\nsignificantly\tO\nreduced\tO\nthe\tO\nnumber\tO\nof\tO\ndark\tO\n-\tO\nstained\tO\nalpha\tO\n-\tO\nmotoneurons\tO\nafter\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nspastic\tB-Disease\nparaparesis\tI-Disease\ncompared\tO\nwith\tO\nthe\tO\nsaline\tO\ngroup\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nIT\tO\nmorphine\tB-Chemical\ninduces\tO\nspastic\tB-Disease\nparaparesis\tI-Disease\nwith\tO\na\tO\nconcomitant\tO\nincrease\tO\nin\tO\nCSF\tO\nglutamate\tB-Chemical\n,\tO\nwhich\tO\nis\tO\ninvolved\tO\nin\tO\nNMDA\tB-Chemical\nreceptor\tO\nactivation\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\nopioids\tO\nmay\tO\nbe\tO\nneurotoxic\tB-Disease\nin\tO\nthe\tO\nsetting\tO\nof\tO\nspinal\tB-Disease\ncord\tI-Disease\nischemia\tI-Disease\nvia\tO\nNMDA\tB-Chemical\nreceptor\tO\nactivation\tO\n.\tO\n\nAcute\tO\nlow\tB-Disease\nback\tI-Disease\npain\tI-Disease\nduring\tO\nintravenous\tO\nadministration\tO\nof\tO\namiodarone\tB-Chemical\n:\tO\na\tO\nreport\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nAmiodarone\tB-Chemical\nrepresents\tO\nan\tO\neffective\tO\nantiarrhythmic\tO\ndrug\tO\nfor\tO\ncardioversion\tO\nof\tO\nrecent\tO\n-\tO\nonset\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n(\tO\nAF\tB-Disease\n)\tO\nand\tO\nmaintenance\tO\nof\tO\nsinus\tO\nrhythm\tO\n.\tO\n\nWe\tO\nbriefly\tO\ndescribe\tO\ntwo\tO\npatients\tO\nsuffering\tO\nfrom\tO\nrecent\tO\n-\tO\nonset\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n,\tO\nwho\tO\nexperienced\tO\nan\tO\nacute\tO\ndevastating\tO\nlow\tB-Disease\nback\tI-Disease\npain\tI-Disease\na\tO\nfew\tO\nminutes\tO\nafter\tO\ninitiation\tO\nof\tO\nintravenous\tO\namiodarone\tB-Chemical\nloading\tO\n.\tO\n\nNotably\tO\n,\tO\nthis\tO\nside\tO\neffect\tO\nhas\tO\nnot\tO\nbeen\tO\never\tO\nreported\tO\nin\tO\nthe\tO\nmedical\tO\nliterature\tO\n.\tO\n\nClinicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\nreaction\tO\nsince\tO\nprompt\tO\ntermination\tO\nof\tO\nparenteral\tO\nadministration\tO\nleads\tO\nto\tO\ncomplete\tO\nresolution\tO\n.\tO\n\nQuantitative\tO\ndrug\tO\nlevels\tO\nin\tO\nstimulant\tO\npsychosis\tB-Disease\n:\tO\nrelationship\tO\nto\tO\nsymptom\tO\nseverity\tO\n,\tO\ncatecholamines\tB-Chemical\nand\tO\nhyperkinesia\tB-Disease\n.\tO\n\nTo\tO\nexamine\tO\nthe\tO\nrelationship\tO\nbetween\tO\nquantitative\tO\nstimulant\tO\ndrug\tO\nlevels\tO\n,\tO\ncatecholamines\tB-Chemical\n,\tO\nand\tO\npsychotic\tB-Disease\nsymptoms\tI-Disease\n,\tO\nnineteen\tO\npatients\tO\nin\tO\na\tO\npsychiatric\tB-Disease\nemergency\tO\nservice\tO\nwith\tO\na\tO\ndiagnosis\tO\nof\tO\namphetamine\tB-Chemical\n-\tO\nor\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\nwere\tO\ninterviewed\tO\n,\tO\nand\tO\nplasma\tO\nand\tO\nurine\tO\nwere\tO\ncollected\tO\nfor\tO\nquantitative\tO\nassays\tO\nof\tO\nstimulant\tO\ndrug\tO\nand\tO\ncatecholamine\tB-Chemical\nmetabolite\tO\nlevels\tO\n.\tO\n\nMethamphetamine\tB-Chemical\nor\tO\namphetamine\tB-Chemical\nlevels\tO\nwere\tO\nrelated\tO\nto\tO\nseveral\tO\npsychopathology\tO\nscores\tO\nand\tO\nthe\tO\nglobal\tO\nhyperkinesia\tB-Disease\nrating\tO\n.\tO\n\nHVA\tO\nlevels\tO\nwere\tO\nrelated\tO\nto\tO\nglobal\tO\nhyperkinesia\tB-Disease\nbut\tO\nnot\tO\nto\tO\npsychopathology\tO\nratings\tO\n.\tO\n\nAlthough\tO\nmany\tO\nother\tO\nfactors\tO\nsuch\tO\nas\tO\nsensitization\tO\nmay\tO\nplay\tO\na\tO\nrole\tO\n,\tO\nintensity\tO\nof\tO\nstimulant\tO\n-\tO\ninduced\tO\npsychotic\tB-Disease\nsymptoms\tI-Disease\nand\tO\nstereotypies\tB-Disease\nappears\tO\nto\tO\nbe\tO\nat\tO\nleast\tO\nin\tO\npart\tO\ndose\tO\n-\tO\nrelated\tO\n.\tO\n\nPheochromocytoma\tB-Disease\nunmasked\tO\nby\tO\namisulpride\tB-Chemical\nand\tO\ntiapride\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\nthe\tO\nunmasking\tO\nof\tO\npheochromocytoma\tB-Disease\nin\tO\na\tO\npatient\tO\ntreated\tO\nwith\tO\namisulpride\tB-Chemical\nand\tO\ntiapride\tB-Chemical\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n42\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwhite\tO\nman\tO\ndeveloped\tO\nacute\tO\nhypertension\tB-Disease\nwith\tO\nsevere\tO\nheadache\tB-Disease\nand\tO\nvomiting\tB-Disease\n2\tO\nhours\tO\nafter\tO\nthe\tO\nfirst\tO\ndoses\tO\nof\tO\namisulpride\tB-Chemical\n100\tO\nmg\tO\nand\tO\ntiapride\tB-Chemical\n100\tO\nmg\tO\n.\tO\n\nBoth\tO\ndrugs\tO\nwere\tO\nimmediately\tO\ndiscontinued\tO\n,\tO\nand\tO\nthe\tO\npatient\tO\nrecovered\tO\nafter\tO\nsubsequent\tO\nnicardipine\tB-Chemical\nand\tO\nverapamil\tB-Chemical\ntreatment\tO\n.\tO\n\nAbdominal\tO\nultrasound\tO\nshowed\tO\nan\tO\nadrenal\tO\nmass\tO\n,\tO\nand\tO\npostoperative\tO\nhistologic\tO\nexamination\tO\nconfirmed\tO\nthe\tO\ndiagnosis\tO\nof\tO\npheochromocytoma\tB-Disease\n.\tO\n\nDISCUSSION\tO\n:\tO\nDrug\tO\n-\tO\ninduced\tO\nsymptoms\tO\nof\tO\npheochromocytoma\tB-Disease\nare\tO\noften\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nsubstituted\tO\nbenzamide\tB-Chemical\ndrugs\tO\n,\tO\nbut\tO\nthe\tO\nunderlying\tO\nmechanism\tO\nis\tO\nunknown\tO\n.\tO\n\nIn\tO\nour\tO\ncase\tO\n,\tO\nuse\tO\nof\tO\nthe\tO\nNaranjo\tO\nprobability\tO\nscale\tO\nindicated\tO\na\tO\npossible\tO\nrelationship\tO\nbetween\tO\nthe\tO\nhypertensive\tB-Disease\ncrisis\tO\nand\tO\namisulpride\tB-Chemical\nand\tO\ntiapride\tB-Chemical\ntherapy\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAs\tO\nof\tO\nMarch\tO\n24\tO\n,\tO\n2005\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\nreported\tO\ncase\tO\nof\tO\namisulpride\tB-Chemical\n-\tO\nand\tO\ntiapride\tB-Chemical\n-\tO\ninduced\tO\nhypertensive\tB-Disease\ncrisis\tO\nin\tO\na\tO\npatient\tO\nwith\tO\npheochromocytoma\tB-Disease\n.\tO\n\nPhysicians\tO\nand\tO\nother\tO\nhealthcare\tO\nprofessionals\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\npotential\tO\nadverse\tO\neffect\tO\nof\tO\ntiapride\tB-Chemical\nand\tO\namisulpride\tB-Chemical\n.\tO\n\nMinor\tO\nneurological\tB-Disease\ndysfunction\tI-Disease\n,\tO\ncognitive\tO\ndevelopment\tO\n,\tO\nand\tO\nsomatic\tO\ndevelopment\tO\nat\tO\nthe\tO\nage\tO\nof\tO\n3\tO\nto\tO\n7\tO\nyears\tO\nafter\tO\ndexamethasone\tB-Chemical\ntreatment\tO\nin\tO\nvery\tO\n-\tO\nlow\tO\nbirth\tO\n-\tO\nweight\tO\ninfants\tO\n.\tO\n\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nassess\tO\nminor\tO\nneurological\tB-Disease\ndysfunction\tI-Disease\n,\tO\ncognitive\tO\ndevelopment\tO\n,\tO\nand\tO\nsomatic\tO\ndevelopment\tO\nafter\tO\ndexamethasone\tB-Chemical\ntherapy\tO\nin\tO\nvery\tO\n-\tO\nlow\tO\n-\tO\nbirthweight\tO\ninfants\tO\n.\tO\n\nThirty\tO\n-\tO\nthree\tO\nchildren\tO\nafter\tO\ndexamethasone\tB-Chemical\ntreatment\tO\nwere\tO\nmatched\tO\nto\tO\n33\tO\nchildren\tO\nwithout\tO\ndexamethasone\tB-Chemical\ntreatment\tO\n.\tO\n\nData\tO\nwere\tO\nassessed\tO\nat\tO\nthe\tO\nage\tO\nof\tO\n3\tO\n-\tO\n7\tO\nyears\tO\n.\tO\n\nDexamethasone\tB-Chemical\nwas\tO\nstarted\tO\nbetween\tO\nthe\tO\n7th\tO\nand\tO\nthe\tO\n28th\tO\nday\tO\nof\tO\nlife\tO\nover\tO\n7\tO\ndays\tO\nwith\tO\na\tO\ntotal\tO\ndose\tO\nof\tO\n2\tO\n.\tO\n35\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n.\tO\n\nExclusion\tO\ncriteria\tO\nwere\tO\nasphyxia\tB-Disease\n,\tO\nmalformations\tB-Disease\n,\tO\nmajor\tO\nsurgical\tO\ninterventions\tO\n,\tO\nsmall\tO\nfor\tO\ngestational\tO\nage\tO\n,\tO\nintraventricular\tO\nhaemorrhage\tB-Disease\ngrades\tO\nIII\tO\nand\tO\nIV\tO\n,\tO\nperiventricular\tB-Disease\nleukomalacia\tI-Disease\n,\tO\nand\tO\nsevere\tO\npsychomotor\tB-Disease\nretardation\tI-Disease\n.\tO\n\nEach\tO\nchild\tO\nwas\tO\nexamined\tO\nby\tO\na\tO\nneuropediatrician\tO\nfor\tO\nminor\tO\nneurological\tB-Disease\ndysfunctions\tI-Disease\nand\tO\ntested\tO\nby\tO\na\tO\npsychologist\tO\nfor\tO\ncognitive\tO\ndevelopment\tO\nwith\tO\na\tO\nKaufman\tO\nAssessment\tO\nBattery\tO\nfor\tO\nChildren\tO\nand\tO\na\tO\nDraw\tO\n-\tO\na\tO\n-\tO\nMan\tO\nTest\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\ndifferences\tO\nin\tO\ndemographic\tO\ndata\tO\n,\tO\ngrowth\tO\n,\tO\nand\tO\nsocio\tO\n-\tO\neconomic\tO\nstatus\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nFine\tO\nmotor\tO\nskills\tO\nand\tO\ngross\tO\nmotor\tO\nfunction\tO\nwere\tO\nsignificantly\tO\nbetter\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\nDraw\tO\n-\tO\na\tO\n-\tO\nMan\tO\nTest\tO\n,\tO\nthe\tO\ncontrol\tO\ngroup\tO\nshowed\tO\nbetter\tO\nresults\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\ndifferences\tO\nin\tO\ndevelopment\tO\nof\tO\nspeech\tO\n,\tO\nsocial\tO\ndevelopment\tO\n,\tO\nand\tO\nthe\tO\nKaufman\tO\nAssessment\tO\nBattery\tO\nfor\tO\nChildren\tO\n.\tO\n\nAfter\tO\ndexamethasone\tB-Chemical\ntreatment\tO\n,\tO\nchildren\tO\nshowed\tO\na\tO\nhigher\tO\nrate\tO\nof\tO\nminor\tO\nneurological\tB-Disease\ndysfunctions\tI-Disease\n.\tO\n\nNeurological\tO\ndevelopment\tO\nwas\tO\naffected\tO\neven\tO\nwithout\tO\nneurological\tO\ndiagnosis\tO\n.\tO\n\nFurther\tO\nlong\tO\n-\tO\nterm\tO\nfollow\tO\n-\tO\nup\tO\nstudies\tO\nwill\tO\nbe\tO\nnecessary\tO\nto\tO\nfully\tO\nevaluate\tO\nthe\tO\nimpact\tO\nof\tO\ndexamethasone\tB-Chemical\non\tO\nneurological\tO\nand\tO\ncognitive\tO\ndevelopment\tO\n.\tO\n\nValproic\tB-Chemical\nacid\tI-Chemical\nI\tO\n:\tO\ntime\tO\ncourse\tO\nof\tO\nlipid\tO\nperoxidation\tO\nbiomarkers\tO\n,\tO\nliver\tB-Disease\ntoxicity\tI-Disease\n,\tO\nand\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\nmetabolite\tO\nlevels\tO\nin\tO\nrats\tO\n.\tO\n\nA\tO\nsingle\tO\ndose\tO\nof\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n(\tO\nVPA\tB-Chemical\n)\tO\n,\tO\nwhich\tO\nis\tO\na\tO\nwidely\tO\nused\tO\nantiepileptic\tO\ndrug\tO\n,\tO\nis\tO\nassociated\tO\nwith\tO\noxidative\tO\nstress\tO\nin\tO\nrats\tO\n,\tO\nas\tO\nrecently\tO\ndemonstrated\tO\nby\tO\nelevated\tO\nlevels\tO\nof\tO\n15\tB-Chemical\n-\tI-Chemical\nF\tI-Chemical\n(\tI-Chemical\n2t\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nisoprostane\tI-Chemical\n(\tO\n15\tB-Chemical\n-\tI-Chemical\nF\tI-Chemical\n(\tI-Chemical\n2t\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nIsoP\tI-Chemical\n)\tO\n.\tO\n\nTo\tO\ndetermine\tO\nwhether\tO\nthere\tO\nwas\tO\na\tO\ntemporal\tO\nrelationship\tO\nbetween\tO\nVPA\tB-Chemical\n-\tO\nassociated\tO\noxidative\tO\nstress\tO\nand\tO\nhepatotoxicity\tB-Disease\n,\tO\nadult\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\ntreated\tO\nip\tO\nwith\tO\nVPA\tB-Chemical\n(\tO\n500\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nor\tO\n0\tO\n.\tO\n9\tO\n%\tO\nsaline\tO\n(\tO\nvehicle\tO\n)\tO\nonce\tO\ndaily\tO\nfor\tO\n2\tO\n,\tO\n4\tO\n,\tO\n7\tO\n,\tO\n10\tO\n,\tO\nor\tO\n14\tO\ndays\tO\n.\tO\n\nOxidative\tO\nstress\tO\nwas\tO\nassessed\tO\nby\tO\ndetermining\tO\nplasma\tO\nand\tO\nliver\tO\nlevels\tO\nof\tO\n15\tB-Chemical\n-\tI-Chemical\nF\tI-Chemical\n(\tI-Chemical\n2t\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nIsoP\tI-Chemical\n,\tO\nlipid\tB-Chemical\nhydroperoxides\tI-Chemical\n(\tO\nLPO\tB-Chemical\n)\tO\n,\tO\nand\tO\nthiobarbituric\tB-Chemical\nacid\tI-Chemical\nreactive\tI-Chemical\nsubstances\tI-Chemical\n(\tO\nTBARs\tB-Chemical\n)\tO\n.\tO\n\nPlasma\tO\nand\tO\nliver\tO\n15\tB-Chemical\n-\tI-Chemical\nF\tI-Chemical\n(\tI-Chemical\n2t\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nIsoP\tI-Chemical\nwere\tO\nelevated\tO\nand\tO\nreached\tO\na\tO\nplateau\tO\nafter\tO\nday\tO\n2\tO\nof\tO\nVPA\tB-Chemical\ntreatment\tO\ncompared\tO\nto\tO\ncontrol\tO\n.\tO\n\nLiver\tO\nLPO\tB-Chemical\nlevels\tO\nwere\tO\nnot\tO\nelevated\tO\nuntil\tO\nday\tO\n7\tO\nof\tO\ntreatment\tO\n(\tO\n1\tO\n.\tO\n8\tO\n-\tO\nfold\tO\nversus\tO\ncontrol\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nLiver\tO\nand\tO\nplasma\tO\nTBARs\tB-Chemical\nwere\tO\nnot\tO\nincreased\tO\nuntil\tO\n14\tO\ndays\tO\n(\tO\n2\tO\n-\tO\nfold\tO\nvs\tO\n.\tO\ncontrol\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nLiver\tB-Disease\ntoxicity\tI-Disease\nwas\tO\nevaluated\tO\nbased\tO\non\tO\nserum\tO\nlevels\tO\nof\tO\nalpha\tO\n-\tO\nglutathione\tB-Chemical\nS\tO\n-\tO\ntransferase\tO\n(\tO\nalpha\tO\n-\tO\nGST\tO\n)\tO\nand\tO\nby\tO\nhistology\tO\n.\tO\n\nSerum\tO\nalpha\tO\n-\tO\nGST\tO\nlevels\tO\nwere\tO\nsignificantly\tO\nelevated\tO\nby\tO\nday\tO\n4\tO\n,\tO\nwhich\tO\ncorresponded\tO\nto\tO\nhepatotoxicity\tB-Disease\nas\tO\nshown\tO\nby\tO\nthe\tO\nincreasing\tO\nincidence\tO\nof\tO\ninflammation\tB-Disease\nof\tO\nthe\tO\nliver\tO\ncapsule\tO\n,\tO\nnecrosis\tB-Disease\n,\tO\nand\tO\nsteatosis\tB-Disease\nthroughout\tO\nthe\tO\nstudy\tO\n.\tO\n\nThe\tO\nliver\tO\nlevels\tO\nof\tO\nbeta\tO\n-\tO\noxidation\tO\nmetabolites\tO\nof\tO\nVPA\tB-Chemical\nwere\tO\ndecreased\tO\nby\tO\nday\tO\n14\tO\n,\tO\nwhile\tO\nthe\tO\nlevels\tO\nof\tO\n4\tB-Chemical\n-\tI-Chemical\nene\tI-Chemical\n-\tI-Chemical\nVPA\tI-Chemical\nand\tO\n(\tO\nE\tO\n)\tO\n-\tO\n2\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndiene\tI-Chemical\n-\tI-Chemical\nVPA\tI-Chemical\nwere\tO\nnot\tO\nelevated\tO\nthroughout\tO\nthe\tO\nstudy\tO\n.\tO\n\nOverall\tO\n,\tO\nthese\tO\nfindings\tO\nindicate\tO\nthat\tO\nVPA\tB-Chemical\ntreatment\tO\nresults\tO\nin\tO\noxidative\tO\nstress\tO\n,\tO\nas\tO\nmeasured\tO\nby\tO\nlevels\tO\nof\tO\n15\tB-Chemical\n-\tI-Chemical\nF\tI-Chemical\n(\tI-Chemical\n2t\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nIsoP\tI-Chemical\n,\tO\nwhich\tO\nprecedes\tO\nthe\tO\nonset\tO\nof\tO\nnecrosis\tB-Disease\n,\tO\nsteatosis\tB-Disease\n,\tO\nand\tO\nelevated\tO\nlevels\tO\nof\tO\nserum\tO\nalpha\tO\n-\tO\nGST\tO\n.\tO\n\nAssessment\tO\nof\tO\nperinatal\tO\nhepatitis\tB-Disease\nB\tI-Disease\nand\tO\nrubella\tB-Disease\nprevention\tO\nin\tO\nNew\tO\nHampshire\tO\ndelivery\tO\nhospitals\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\ncurrent\tO\nperformance\tO\non\tO\nrecommended\tO\nperinatal\tO\nhepatitis\tB-Disease\nB\tI-Disease\nand\tO\nrubella\tB-Disease\nprevention\tO\npractices\tO\nin\tO\nNew\tO\nHampshire\tO\n.\tO\n\nMETHODS\tO\n:\tO\nData\tO\nwere\tO\nextracted\tO\nfrom\tO\n2021\tO\npaired\tO\nmother\tO\n-\tO\ninfant\tO\nrecords\tO\nfor\tO\nthe\tO\nyear\tO\n2000\tO\nbirth\tO\ncohort\tO\nin\tO\nNew\tO\nHampshire\tO\n'\tO\ns\tO\n25\tO\ndelivery\tO\nhospitals\tO\n.\tO\n\nAssessment\tO\nwas\tO\ndone\tO\non\tO\nthe\tO\nfollowing\tO\n:\tO\nprenatal\tO\nscreening\tO\nfor\tO\nhepatitis\tB-Disease\nB\tI-Disease\nand\tO\nrubella\tB-Disease\n,\tO\nadministration\tO\nof\tO\nthe\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvaccine\tO\nbirth\tO\ndose\tO\nto\tO\nall\tO\ninfants\tO\n,\tO\nadministration\tO\nof\tO\nhepatitis\tB-Disease\nB\tI-Disease\nimmune\tO\nglobulin\tO\nto\tO\ninfants\tO\nwho\tO\nwere\tO\nborn\tO\nto\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nsurface\tI-Chemical\nantigen\tI-Chemical\n-\tO\npositive\tO\nmothers\tO\n,\tO\nrubella\tB-Disease\nimmunity\tO\n,\tO\nand\tO\nadministration\tO\nof\tO\nin\tO\n-\tO\nhospital\tO\npostpartum\tO\nrubella\tB-Disease\nvaccine\tO\nto\tO\nrubella\tB-Disease\nnonimmune\tO\nwomen\tO\n.\tO\n\nRESULTS\tO\n:\tO\nPrenatal\tO\nscreening\tO\nrates\tO\nfor\tO\nhepatitis\tB-Disease\nB\tI-Disease\n(\tO\n98\tO\n.\tO\n8\tO\n%\tO\n)\tO\nand\tO\nrubella\tB-Disease\n(\tO\n99\tO\n.\tO\n4\tO\n%\tO\n)\tO\nwere\tO\nhigh\tO\n.\tO\n\nHepatitis\tB-Disease\nB\tI-Disease\nvaccine\tO\nbirth\tO\ndose\tO\nwas\tO\nadministered\tO\nto\tO\n76\tO\n.\tO\n2\tO\n%\tO\nof\tO\nall\tO\ninfants\tO\n.\tO\n\nAll\tO\ninfants\tO\nwho\tO\nwere\tO\nborn\tO\nto\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nsurface\tI-Chemical\nantigen\tI-Chemical\n-\tO\npositive\tO\nmothers\tO\nalso\tO\nreceived\tO\nhepatitis\tB-Disease\nB\tI-Disease\nimmune\tO\nglobulin\tO\n.\tO\n\nMultivariate\tO\nlogistic\tO\nregression\tO\nshowed\tO\nthat\tO\nthe\tO\nmonth\tO\nof\tO\ndelivery\tO\nand\tO\ninfant\tO\nbirth\tO\nweight\tO\nwere\tO\nindependent\tO\npredictors\tO\nof\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvaccination\tO\n.\tO\n\nThe\tO\nproportion\tO\nof\tO\ninfants\tO\nwho\tO\nwere\tO\nvaccinated\tO\nin\tO\nJanuary\tO\nand\tO\nFebruary\tO\n2000\tO\n(\tO\n48\tO\n.\tO\n5\tO\n%\tO\nand\tO\n67\tO\n.\tO\n5\tO\n%\tO\n,\tO\nrespectively\tO\n)\tO\nwas\tO\nless\tO\nthan\tO\nany\tO\nother\tO\nmonths\tO\n,\tO\nwhereas\tO\nthe\tO\nproportion\tO\nwho\tO\nwere\tO\nvaccinated\tO\nin\tO\nDecember\tO\n2000\tO\n(\tO\n88\tO\n.\tO\n2\tO\n%\tO\n)\tO\nwas\tO\nthe\tO\nhighest\tO\n.\tO\n\nWomen\tO\nwho\tO\nwere\tO\nborn\tO\nbetween\tO\n1971\tO\nand\tO\n1975\tO\nhad\tO\nthe\tO\nhighest\tO\nrate\tO\nof\tO\nrubella\tB-Disease\nnonimmunity\tO\n(\tO\n9\tO\n.\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nIn\tO\n-\tO\nhospital\tO\npostpartum\tO\nrubella\tB-Disease\nvaccine\tO\nadministration\tO\nwas\tO\ndocumented\tO\nfor\tO\n75\tO\n.\tO\n6\tO\n%\tO\nof\tO\nnonimmune\tO\nwomen\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nstudy\tO\ndocuments\tO\ngood\tO\ncompliance\tO\nin\tO\nNew\tO\nHampshire\tO\n'\tO\ns\tO\nbirthing\tO\nhospitals\tO\nwith\tO\nnational\tO\nguidelines\tO\nfor\tO\nperinatal\tO\nhepatitis\tB-Disease\nB\tI-Disease\nand\tO\nrubella\tB-Disease\nprevention\tO\nand\tO\nhighlights\tO\npotential\tO\nareas\tO\nfor\tO\nimprovement\tO\n.\tO\n\nSuccinylcholine\tB-Chemical\n-\tO\ninduced\tO\nmasseter\tB-Disease\nmuscle\tI-Disease\nrigidity\tI-Disease\nduring\tO\nbronchoscopic\tO\nremoval\tO\nof\tO\na\tO\ntracheal\tO\nforeign\tO\nbody\tO\n.\tO\n\nMasseter\tB-Disease\nmuscle\tI-Disease\nrigidity\tI-Disease\nduring\tO\ngeneral\tO\nanesthesia\tO\nis\tO\nconsidered\tO\nan\tO\nearly\tO\nwarning\tO\nsign\tO\nof\tO\na\tO\npossible\tO\nepisode\tO\nof\tO\nmalignant\tB-Disease\nhyperthermia\tI-Disease\n.\tO\n\nThe\tO\ndecision\tO\nwhether\tO\nto\tO\ncontinue\tO\nor\tO\ndiscontinue\tO\nthe\tO\nprocedure\tO\ndepends\tO\non\tO\nthe\tO\nurgency\tO\nof\tO\nthe\tO\nsurgery\tO\nand\tO\nseverity\tO\nof\tO\nmasseter\tB-Disease\nmuscle\tI-Disease\nrigidity\tI-Disease\n.\tO\n\nHere\tO\n,\tO\nwe\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\nsevere\tO\nmasseter\tB-Disease\nmuscle\tI-Disease\nrigidity\tI-Disease\n(\tO\njaw\tB-Disease\nof\tI-Disease\nsteel\tI-Disease\n)\tO\nafter\tO\nsuccinylcholine\tB-Chemical\n(\tO\nSch\tB-Chemical\n)\tO\nadministration\tO\nduring\tO\ngeneral\tO\nanesthetic\tO\nmanagement\tO\nfor\tO\nrigid\tO\nbronchoscopic\tO\nremoval\tO\nof\tO\na\tO\ntracheal\tO\nforeign\tO\nbody\tO\n.\tO\n\nAnesthesia\tO\nwas\tO\ncontinued\tO\nuneventfully\tO\nwith\tO\npropofol\tB-Chemical\ninfusion\tO\nwhile\tO\nall\tO\nfacilities\tO\nwere\tO\navailable\tO\nto\tO\ndetect\tO\nand\tO\ntreat\tO\nmalignant\tB-Disease\nhyperthermia\tI-Disease\n.\tO\n\nDexrazoxane\tB-Chemical\nprotects\tO\nagainst\tO\nmyelosuppression\tB-Disease\nfrom\tO\nthe\tO\nDNA\tO\ncleavage\tO\n-\tO\nenhancing\tO\ndrugs\tO\netoposide\tB-Chemical\nand\tO\ndaunorubicin\tB-Chemical\nbut\tO\nnot\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nPURPOSE\tO\n:\tO\nThe\tO\nanthracyclines\tB-Chemical\ndaunorubicin\tB-Chemical\nand\tO\ndoxorubicin\tB-Chemical\nand\tO\nthe\tO\nepipodophyllotoxin\tB-Chemical\netoposide\tB-Chemical\nare\tO\npotent\tO\nDNA\tO\ncleavage\tO\n-\tO\nenhancing\tO\ndrugs\tO\nthat\tO\nare\tO\nwidely\tO\nused\tO\nin\tO\nclinical\tO\noncology\tO\n;\tO\nhowever\tO\n,\tO\nmyelosuppression\tB-Disease\nand\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nlimit\tO\ntheir\tO\nuse\tO\n.\tO\n\nDexrazoxane\tB-Chemical\n(\tO\nICRF\tB-Chemical\n-\tI-Chemical\n187\tI-Chemical\n)\tO\nis\tO\nrecommended\tO\nfor\tO\nprotection\tO\nagainst\tO\nanthracycline\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nEXPERIMENTAL\tO\nDESIGN\tO\n:\tO\nBecause\tO\nof\tO\ntheir\tO\nwidespread\tO\nuse\tO\n,\tO\nthe\tO\nhematologic\tB-Disease\ntoxicity\tI-Disease\nfollowing\tO\ncoadministration\tO\nof\tO\ndexrazoxane\tB-Chemical\nand\tO\nthese\tO\nthree\tO\nstructurally\tO\ndifferent\tO\nDNA\tO\ncleavage\tO\nenhancers\tO\nwas\tO\ninvestigated\tO\n:\tO\nSensitivity\tO\nof\tO\nhuman\tO\nand\tO\nmurine\tO\nblood\tO\nprogenitor\tO\ncells\tO\nto\tO\netoposide\tB-Chemical\n,\tO\ndaunorubicin\tB-Chemical\n,\tO\nand\tO\ndoxorubicin\tB-Chemical\n+\tO\n/\tO\n-\tO\ndexrazoxane\tB-Chemical\nwas\tO\ndetermined\tO\nin\tO\ngranulocyte\tO\n-\tO\nmacrophage\tO\ncolony\tO\nforming\tO\nassays\tO\n.\tO\n\nLikewise\tO\n,\tO\nin\tO\nvivo\tO\n,\tO\nB6D2F1\tO\nmice\tO\nwere\tO\ntreated\tO\nwith\tO\netoposide\tB-Chemical\n,\tO\ndaunorubicin\tB-Chemical\n,\tO\nand\tO\ndoxorubicin\tB-Chemical\n,\tO\nwith\tO\nor\tO\nwithout\tO\ndexrazoxane\tB-Chemical\nover\tO\na\tO\nwide\tO\nrange\tO\nof\tO\ndoses\tO\n:\tO\nposttreatment\tO\n,\tO\na\tO\nfull\tO\nhematologic\tO\nevaluation\tO\nwas\tO\ndone\tO\n.\tO\n\nRESULTS\tO\n:\tO\nNontoxic\tO\ndoses\tO\nof\tO\ndexrazoxane\tB-Chemical\nreduced\tO\nmyelosuppression\tB-Disease\nand\tO\nweight\tB-Disease\nloss\tI-Disease\nfrom\tO\ndaunorubicin\tB-Chemical\nand\tO\netoposide\tB-Chemical\nin\tO\nmice\tO\nand\tO\nantagonized\tO\ntheir\tO\nantiproliferative\tO\neffects\tO\nin\tO\nthe\tO\ncolony\tO\nassay\tO\n;\tO\nhowever\tO\n,\tO\ndexrazoxane\tB-Chemical\nneither\tO\nreduced\tO\nmyelosuppression\tB-Disease\n,\tO\nweight\tB-Disease\nloss\tI-Disease\n,\tO\nnor\tO\nthe\tO\nin\tO\nvitro\tO\ncytotoxicity\tB-Disease\nfrom\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nAlthough\tO\nour\tO\nfindings\tO\nsupport\tO\nthe\tO\nobservation\tO\nthat\tO\ndexrazoxane\tB-Chemical\nreduces\tO\nneither\tO\nhematologic\tO\nactivity\tO\nnor\tO\nantitumor\tO\nactivity\tO\nfrom\tO\ndoxorubicin\tB-Chemical\nclinically\tO\n,\tO\nthe\tO\npotent\tO\nantagonism\tO\nof\tO\ndaunorubicin\tB-Chemical\nactivity\tO\nraises\tO\nconcern\tO\n;\tO\na\tO\npossible\tO\ninterference\tO\nwith\tO\nanticancer\tO\nefficacy\tO\ncertainly\tO\nwould\tO\ncall\tO\nfor\tO\nrenewed\tO\nattention\tO\n.\tO\n\nOur\tO\ndata\tO\nalso\tO\nsuggest\tO\nthat\tO\nsignificant\tO\netoposide\tB-Chemical\ndose\tO\nescalation\tO\nis\tO\nperhaps\tO\npossible\tO\nby\tO\nthe\tO\nuse\tO\nof\tO\ndexrazoxane\tB-Chemical\n.\tO\n\nClinical\tO\ntrials\tO\nin\tO\npatients\tO\nwith\tO\nbrain\tO\nmetastases\tB-Disease\ncombining\tO\ndexrazoxane\tB-Chemical\nand\tO\nhigh\tO\ndoses\tO\nof\tO\netoposide\tB-Chemical\nis\tO\nongoing\tO\nwith\tO\nthe\tO\naim\tO\nof\tO\nimproving\tO\nefficacy\tO\nwithout\tO\naggravating\tO\nhematologic\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nIf\tO\nsuccessful\tO\n,\tO\nthis\tO\nrepresents\tO\nan\tO\nexciting\tO\nmechanism\tO\nfor\tO\npharmacologic\tO\nregulation\tO\nof\tO\nside\tO\neffects\tO\nfrom\tO\ncytotoxic\tO\nchemotherapy\tO\n.\tO\n\nAssessment\tO\nof\tO\nthe\tO\nonset\tO\nand\tO\npersistence\tO\nof\tO\namnesia\tB-Disease\nduring\tO\nprocedural\tO\nsedation\tO\nwith\tO\npropofol\tB-Chemical\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nassess\tO\npatients\tO\n'\tO\nability\tO\nto\tO\nrepeat\tO\nand\tO\nrecall\tO\nwords\tO\npresented\tO\nto\tO\nthem\tO\nwhile\tO\nundergoing\tO\nprocedural\tO\nsedation\tO\nwith\tO\npropofol\tB-Chemical\n,\tO\nand\tO\ncorrelate\tO\ntheir\tO\nrecall\tO\nwith\tO\ntheir\tO\nlevel\tO\nof\tO\nawareness\tO\nas\tO\nmeasured\tO\nby\tO\nbispectral\tO\nindex\tO\n(\tO\nBIS\tO\n)\tO\nmonitoring\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nwas\tO\na\tO\nprospective\tO\n,\tO\nsingle\tO\n-\tO\nintervention\tO\nstudy\tO\nof\tO\nconsenting\tO\nadult\tO\npatients\tO\nundergoing\tO\nprocedural\tO\nsedation\tO\nwith\tO\npropofol\tB-Chemical\nbetween\tO\nDecember\tO\n28\tO\n,\tO\n2002\tO\n,\tO\nand\tO\nOctober\tO\n31\tO\n,\tO\n2003\tO\n.\tO\n\nBIS\tO\nmonitoring\tO\nwas\tO\ninitiated\tO\nstarting\tO\n3\tO\nminutes\tO\nbefore\tO\nthe\tO\nprocedure\tO\nand\tO\ncontinuing\tO\nuntil\tO\nthe\tO\npatient\tO\nhad\tO\nregained\tO\nbaseline\tO\nmental\tO\nstatus\tO\n.\tO\n\nAt\tO\n1\tO\n-\tO\nminute\tO\nintervals\tO\nduring\tO\nthe\tO\nprocedural\tO\nsedation\tO\n,\tO\nuntil\tO\nthe\tO\npatient\tO\nregained\tO\nbaseline\tO\nmental\tO\nstatus\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nprocedure\tO\n,\tO\na\tO\nword\tO\nfrom\tO\na\tO\nstandardized\tO\nlist\tO\nwas\tO\nread\tO\naloud\tO\n,\tO\nand\tO\nthe\tO\npatient\tO\nwas\tO\nasked\tO\nto\tO\nimmediately\tO\nrepeat\tO\nthe\tO\nword\tO\nto\tO\nthe\tO\ninvestigator\tO\n.\tO\n\nThe\tO\nBIS\tO\nscore\tO\nat\tO\nthe\tO\ntime\tO\nthe\tO\nword\tO\nwas\tO\nread\tO\nand\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nability\tO\nto\tO\nrepeat\tO\nthe\tO\nword\tO\nwere\tO\nrecorded\tO\n.\tO\n\nAfter\tO\nthe\tO\nprocedure\tO\n,\tO\nthe\tO\npatient\tO\nwas\tO\nasked\tO\nto\tO\nstate\tO\nall\tO\nof\tO\nthe\tO\nwords\tO\nfrom\tO\nthe\tO\nlist\tO\nthat\tO\nhe\tO\nor\tO\nshe\tO\ncould\tO\nrecall\tO\n,\tO\nand\tO\nto\tO\nidentify\tO\nthe\tO\nlast\tO\nword\tO\nrecalled\tO\nfrom\tO\nprior\tO\nto\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nprocedure\tO\nand\tO\nthe\tO\nfirst\tO\nword\tO\nrecalled\tO\nfrom\tO\nafter\tO\nthe\tO\nprocedure\tO\nwas\tO\ncompleted\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSeventy\tO\n-\tO\nfive\tO\nconsenting\tO\npatients\tO\nwere\tO\nenrolled\tO\n;\tO\none\tO\npatient\tO\nwas\tO\nexcluded\tO\nfrom\tO\ndata\tO\nanalysis\tO\nfor\tO\na\tO\nprotocol\tO\nviolation\tO\n.\tO\n\nNo\tO\nserious\tO\nadverse\tO\nevents\tO\nwere\tO\nnoted\tO\nduring\tO\nthe\tO\nprocedural\tO\nsedations\tO\n.\tO\n\nThe\tO\nmean\tO\n(\tO\n+\tO\n/\tO\n-\tO\nstandard\tO\ndeviation\tO\n)\tO\ntime\tO\nof\tO\ndata\tO\ncollection\tO\nwas\tO\n16\tO\n.\tO\n4\tO\nminutes\tO\n(\tO\n+\tO\n/\tO\n-\tO\n7\tO\n.\tO\n1\tO\n;\tO\nrange\tO\n5\tO\nto\tO\n34\tO\nminutes\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\ninitial\tO\n(\tO\npreprocedure\tO\n)\tO\nBIS\tO\nscore\tO\nwas\tO\n97\tO\n.\tO\n1\tO\n(\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n3\tO\n;\tO\nrange\tO\n92\tO\nto\tO\n99\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nlowest\tO\nBIS\tO\nscore\tO\noccurring\tO\nduring\tO\nthese\tO\nprocedural\tO\nsedations\tO\nwas\tO\n66\tO\n.\tO\n9\tO\n(\tO\n+\tO\n/\tO\n-\tO\n14\tO\n.\tO\n4\tO\n;\tO\nrange\tO\n33\tO\nto\tO\n91\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nlowest\tO\nBIS\tO\nscore\tO\ncorresponding\tO\nto\tO\nthe\tO\nability\tO\nof\tO\nthe\tO\npatient\tO\nto\tO\nimmediately\tO\nrepeat\tO\nwords\tO\nread\tO\nfrom\tO\nthe\tO\nlist\tO\nwas\tO\n77\tO\n.\tO\n1\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n74\tO\n.\tO\n3\tO\nto\tO\n80\tO\n.\tO\n0\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nhighest\tO\nBIS\tO\nscore\tO\ncorresponding\tO\nto\tO\nthe\tO\ninability\tB-Disease\nto\tI-Disease\nrepeat\tI-Disease\nwords\tI-Disease\nwas\tO\n81\tO\n.\tO\n5\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n78\tO\n.\tO\n1\tO\nto\tO\n84\tO\n.\tO\n8\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nBIS\tO\nscore\tO\ncorresponding\tO\nto\tO\nthe\tO\nlast\tO\nword\tO\nrecalled\tO\nfrom\tO\nprior\tO\nto\tO\nthe\tO\ninitiation\tO\nof\tO\nthe\tO\nsedation\tO\nwas\tO\n96\tO\n.\tO\n7\tO\n(\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n4\tO\n;\tO\nrange\tO\n84\tO\nto\tO\n98\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nBIS\tO\nscore\tO\ncorresponding\tO\nto\tO\nthe\tO\nfirst\tO\nword\tO\nrecalled\tO\nafter\tO\nthe\tO\nprocedure\tO\nwas\tO\ncompleted\tO\nwas\tO\n91\tO\n.\tO\n2\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n88\tO\n.\tO\n1\tO\nto\tO\n94\tO\n.\tO\n3\tO\n)\tO\n.\tO\n\nAll\tO\npatients\tO\nrecalled\tO\nat\tO\nleast\tO\none\tO\nword\tO\nthat\tO\nhad\tO\nbeen\tO\nread\tO\nto\tO\nthem\tO\nduring\tO\nthe\tO\nprotocol\tO\n.\tO\n\nThe\tO\nmean\tO\nlowest\tO\nBIS\tO\nscore\tO\nfor\tO\nany\tO\nrecalled\tO\nword\tO\nwas\tO\n91\tO\n.\tO\n5\tO\n(\tO\n+\tO\n/\tO\n-\tO\n11\tO\n.\tO\n1\tO\n;\tO\nrange\tO\n79\tO\nto\tO\n98\tO\n)\tO\n,\tO\nand\tO\nno\tO\nwords\tO\nwere\tO\nrecalled\tO\nwhen\tO\nthe\tO\ncorresponding\tO\nBIS\tO\nscore\tO\nwas\tO\nless\tO\nthan\tO\n90\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThere\tO\nis\tO\na\tO\nrange\tO\nof\tO\nBIS\tO\nscores\tO\nduring\tO\nwhich\tO\nsedated\tO\npatients\tO\nare\tO\nable\tO\nto\tO\nrepeat\tO\nwords\tO\nread\tO\nto\tO\nthem\tO\nbut\tO\nare\tO\nnot\tO\nable\tO\nto\tO\nsubsequently\tO\nrecall\tO\nthese\tO\nwords\tO\n.\tO\n\nFurthermore\tO\n,\tO\npatients\tO\nhad\tO\nno\tO\nrecall\tO\nof\tO\nwords\tO\nrepeated\tO\nprior\tO\nto\tO\nprocedural\tO\nsedation\tO\nin\tO\nBIS\tO\nranges\tO\nassociated\tO\nwith\tO\nrecall\tO\nafter\tO\nprocedural\tO\nsedation\tO\n,\tO\nsuggestive\tO\nof\tO\nretrograde\tB-Disease\namnesia\tI-Disease\n.\tO\n\nAmiodarone\tB-Chemical\npulmonary\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nAmiodarone\tB-Chemical\nis\tO\nan\tO\neffective\tO\nantiarrhythmic\tO\nagent\tO\nwhose\tO\nutility\tO\nis\tO\nlimited\tO\nby\tO\nmany\tO\nside\tO\n-\tO\neffects\tO\n,\tO\nthe\tO\nmost\tO\nproblematic\tO\nbeing\tO\npneumonitis\tB-Disease\n.\tO\n\nThe\tO\npulmonary\tB-Disease\ntoxicity\tI-Disease\nof\tO\namiodarone\tB-Chemical\nis\tO\nthought\tO\nto\tO\nresult\tO\nfrom\tO\ndirect\tO\ninjury\tO\nrelated\tO\nto\tO\nthe\tO\nintracellular\tO\naccumulation\tO\nof\tO\nphospholipid\tO\nand\tO\nT\tO\ncell\tO\n-\tO\nmediated\tO\nhypersensitivity\tB-Disease\npneumonitis\tI-Disease\n.\tO\n\nThe\tO\nclinical\tO\nand\tO\nradiographic\tO\nfeatures\tO\nof\tO\namiodarone\tB-Chemical\n-\tO\ninduced\tO\npulmonary\tB-Disease\ntoxicity\tI-Disease\nare\tO\ncharacteristic\tO\nbut\tO\nnonspecific\tO\n.\tO\n\nThe\tO\ndiagnosis\tO\ndepends\tO\non\tO\nexclusion\tO\nof\tO\nother\tO\nentities\tO\n,\tO\nsuch\tO\nas\tO\nheart\tB-Disease\nfailure\tI-Disease\n,\tO\ninfection\tB-Disease\n,\tO\nand\tO\nmalignancy\tB-Disease\n.\tO\n\nWhile\tO\nwithdrawal\tO\nof\tO\namiodarone\tB-Chemical\nleads\tO\nto\tO\nclinical\tO\nimprovement\tO\nin\tO\nmajority\tO\nof\tO\ncases\tO\n,\tO\nthis\tO\nis\tO\nnot\tO\nalways\tO\npossible\tO\nor\tO\nadvisable\tO\n.\tO\n\nDose\tO\nreduction\tO\nor\tO\nconcomitant\tO\nsteroid\tB-Chemical\ntherapy\tO\nmay\tO\nhave\tO\na\tO\nrole\tO\nin\tO\nselected\tO\npatients\tO\n.\tO\n\nTwo\tO\nprodrugs\tO\nof\tO\npotent\tO\nand\tO\nselective\tO\nGluR5\tO\nkainate\tB-Chemical\nreceptor\tO\nantagonists\tO\nactives\tO\nin\tO\nthree\tO\nanimal\tO\nmodels\tO\nof\tO\npain\tB-Disease\n.\tO\n\nAmino\tO\nacids\tO\n5\tO\nand\tO\n7\tO\n,\tO\ntwo\tO\npotent\tO\nand\tO\nselective\tO\ncompetitive\tO\nGluR5\tO\nKA\tB-Chemical\nreceptor\tO\nantagonists\tO\n,\tO\nexhibited\tO\nhigh\tO\nGluR5\tO\nreceptor\tO\naffinity\tO\nover\tO\nother\tO\nglutamate\tB-Chemical\nreceptors\tO\n.\tO\n\nTheir\tO\nester\tO\nprodrugs\tO\n6\tO\nand\tO\n8\tO\nwere\tO\norally\tO\nactive\tO\nin\tO\nthree\tO\nmodels\tO\nof\tO\npain\tB-Disease\n:\tO\nreversal\tO\nof\tO\nformalin\tB-Chemical\n-\tO\ninduced\tO\npaw\tO\nlicking\tO\n,\tO\ncarrageenan\tB-Chemical\n-\tO\ninduced\tO\nthermal\tB-Disease\nhyperalgesia\tI-Disease\n,\tO\nand\tO\ncapsaicin\tB-Chemical\n-\tO\ninduced\tO\nmechanical\tB-Disease\nhyperalgesia\tI-Disease\n.\tO\n\nPossible\tO\nazithromycin\tB-Chemical\n-\tO\nassociated\tO\nhiccups\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\npersistent\tO\nhiccups\tB-Disease\nassociated\tO\nby\tO\nazithromycin\tB-Chemical\ntherapy\tO\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n76\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\npresented\tO\nwith\tO\npersistent\tO\nhiccups\tB-Disease\nafter\tO\nbeginning\tO\nazithromycin\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\npharyngitis\tB-Disease\n.\tO\n\nHiccups\tB-Disease\nwere\tO\npersistent\tO\nand\tO\nexhausting\tO\n.\tO\n\nDiscontinuation\tO\nof\tO\nazithromycin\tB-Chemical\nand\tO\ntherapy\tO\nwith\tO\nbaclofen\tB-Chemical\nfinally\tO\nresolved\tO\nhiccups\tB-Disease\n.\tO\n\nNo\tO\norganic\tO\ncause\tO\nof\tO\nhiccups\tB-Disease\nwas\tO\nidentified\tO\ndespite\tO\nextensive\tO\ninvestigation\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nPharmacotherapeutic\tO\nagents\tO\nhave\tO\nbeen\tO\nuncommonly\tO\nassociated\tO\nwith\tO\nhiccups\tB-Disease\n.\tO\n\nCorticosteroids\tO\n(\tO\ndexamethasone\tB-Chemical\nand\tO\nmethylprednisolone\tB-Chemical\n)\tO\n,\tO\nbenzodiazepines\tB-Chemical\n(\tO\nmidazolam\tB-Chemical\n)\tO\nand\tO\ngeneral\tO\nanaesthesia\tO\nhave\tO\nbeen\tO\nthe\tO\nspecific\tO\nagents\tO\nmentioned\tO\nmost\tO\nfrequently\tO\nin\tO\nthe\tO\nliterature\tO\nas\tO\nbeing\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nhiccups\tB-Disease\n.\tO\n\nFew\tO\ncases\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nhiccups\tB-Disease\nhave\tO\nbeen\tO\nreported\tO\nrelated\tO\nto\tO\nmacrolide\tB-Chemical\nantimicrobials\tO\n.\tO\n\nUsing\tO\nthe\tO\nNaranjo\tO\nadverse\tO\neffect\tO\nreaction\tO\nprobability\tO\nscale\tO\nthis\tO\nevent\tO\ncould\tO\nbe\tO\nclassified\tO\nas\tO\npossible\tO\n(\tO\nscore\tO\n5\tO\npoints\tO\n)\tO\n,\tO\nmostly\tO\nbecause\tO\nof\tO\nthe\tO\nclose\tO\ntemporal\tO\nsequence\tO\n,\tO\nprevious\tO\nreports\tO\non\tO\nthis\tO\nreaction\tO\nwith\tO\nother\tO\nmacrolides\tB-Chemical\nand\tO\nthe\tO\nabsence\tO\nof\tO\nany\tO\nalternative\tO\nexplanation\tO\nfor\tO\nhiccups\tB-Disease\n.\tO\n\nOur\tO\nhypothesis\tO\nis\tO\nthat\tO\na\tO\nvagal\tO\nmechanism\tO\nmediated\tO\nby\tO\nazithromycin\tB-Chemical\ncould\tO\nbe\tO\nthe\tO\npathogenesis\tO\nof\tO\nhiccups\tB-Disease\nin\tO\nour\tO\npatient\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDiagnosis\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nhiccups\tB-Disease\nis\tO\ndifficult\tO\nand\tO\noften\tO\nachieved\tO\nonly\tO\nby\tO\na\tO\nprocess\tO\nof\tO\nelimination\tO\n.\tO\n\nHowever\tO\n,\tO\nmacrolide\tB-Chemical\nantimicrobials\tO\nhave\tO\nbeen\tO\nreported\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nhiccups\tB-Disease\nand\tO\nvagal\tO\nmechanism\tO\ncould\tO\nexplain\tO\nthe\tO\ndevelopment\tO\nof\tO\nthis\tO\nside\tO\n-\tO\neffect\tO\n.\tO\n\nCalcium\tB-Chemical\ncarbonate\tI-Chemical\ntoxicity\tB-Disease\n:\tO\nthe\tO\nupdated\tO\nmilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\n;\tO\nreport\tO\nof\tO\n3\tO\ncases\tO\nand\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\n3\tO\npatients\tO\nwith\tO\ncalcium\tB-Chemical\ncarbonate\tI-Chemical\n-\tO\ninduced\tO\nhypercalcemia\tB-Disease\nand\tO\ngain\tO\ninsights\tO\ninto\tO\nthe\tO\ncause\tO\nand\tO\nmanagement\tO\nof\tO\nthe\tO\nmilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nreport\tO\nthe\tO\nclinical\tO\nand\tO\nlaboratory\tO\ndata\tO\nin\tO\n3\tO\npatients\tO\nwho\tO\npresented\tO\nwith\tO\nsevere\tO\nhypercalcemia\tB-Disease\n(\tO\ncorrected\tO\nserum\tO\ncalcium\tB-Chemical\n>\tO\nor\tO\n=\tO\n14\tO\nmg\tO\n/\tO\ndL\tO\n)\tO\nand\tO\nreview\tO\nthe\tO\npertinent\tO\nliterature\tO\non\tO\nmilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\n3\tO\npatients\tO\nhad\tO\nacute\tB-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\n,\tO\nrelative\tO\nmetabolic\tB-Disease\nalkalosis\tI-Disease\n,\tO\nand\tO\nlow\tO\nparathyroid\tO\nhormone\tO\n(\tO\nPTH\tO\n)\tO\n,\tO\nPTH\tO\n-\tO\nrelated\tO\npeptide\tO\n,\tO\nand\tO\n1\tB-Chemical\n,\tI-Chemical\n25\tI-Chemical\n-\tI-Chemical\ndihydroxyvitamin\tI-Chemical\nD\tI-Chemical\nconcentrations\tO\n.\tO\n\nNo\tO\nmalignant\tO\nlesion\tO\nwas\tO\nfound\tO\n.\tO\n\nTreatment\tO\nincluded\tO\naggressive\tO\nhydration\tO\nand\tO\nvaried\tO\namounts\tO\nof\tO\nfurosemide\tB-Chemical\n.\tO\n\nThe\tO\n2\tO\npatients\tO\nwith\tO\nthe\tO\nhigher\tO\nserum\tO\ncalcium\tB-Chemical\nconcentrations\tO\nreceived\tO\npamidronate\tB-Chemical\nintravenously\tO\n(\tO\n60\tO\nand\tO\n30\tO\nmg\tO\n,\tO\nrespectively\tO\n)\tO\n,\tO\nwhich\tO\ncaused\tO\nsevere\tO\nhypocalcemia\tB-Disease\n.\tO\n\nOf\tO\nthe\tO\n3\tO\npatients\tO\n,\tO\n2\tO\nwere\tO\ningesting\tO\nacceptable\tO\ndoses\tO\nof\tO\nelemental\tO\ncalcium\tB-Chemical\n(\tO\n1\tO\ng\tO\nand\tO\n2\tO\ng\tO\ndaily\tO\n,\tO\nrespectively\tO\n)\tO\nin\tO\nthe\tO\nform\tO\nof\tO\ncalcium\tB-Chemical\ncarbonate\tI-Chemical\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nour\tO\nhighlighted\tO\ncases\tO\n,\tO\nwe\tO\nreview\tO\nthe\tO\nhistory\tO\n,\tO\nclassification\tO\n,\tO\npathophysiologic\tO\nfeatures\tO\n,\tO\nand\tO\ntreatment\tO\nof\tO\nmilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\nand\tO\nsummarize\tO\nthe\tO\ncases\tO\nreported\tO\nfrom\tO\nearly\tO\n1995\tO\nto\tO\nNovember\tO\n2003\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nMilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\nmay\tO\nbe\tO\na\tO\ncommon\tO\ncause\tO\nof\tO\nunexplained\tO\nhypercalcemia\tB-Disease\nand\tO\ncan\tO\nbe\tO\nprecipitated\tO\nby\tO\nsmall\tO\namounts\tO\nof\tO\norally\tO\ningested\tO\ncalcium\tB-Chemical\ncarbonate\tI-Chemical\nin\tO\nsusceptible\tO\npersons\tO\n.\tO\n\nTreatment\tO\nwith\tO\nhydration\tO\n,\tO\nfurosemide\tB-Chemical\n,\tO\nand\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ncalcium\tB-Chemical\nand\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nsource\tO\nis\tO\nadequate\tO\n.\tO\n\nPamidronate\tB-Chemical\ntreatment\tO\nis\tO\nassociated\tO\nwith\tO\nconsiderable\tO\nrisk\tO\nfor\tO\nhypocalcemia\tB-Disease\n,\tO\neven\tO\nin\tO\ncases\tO\nof\tO\ninitially\tO\nsevere\tO\nhypercalcemia\tB-Disease\n.\tO\n\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\nleukocytoclastic\tB-Disease\nvasculitis\tI-Disease\n.\tO\n\nSkin\tO\nreactions\tO\nassociated\tO\nwith\tO\noral\tO\ncoumarin\tB-Chemical\n-\tO\nderived\tO\nanticoagulants\tO\nare\tO\nan\tO\nuncommon\tO\noccurrence\tO\n.\tO\n\nLeukocytoclastic\tB-Disease\nvasculitis\tI-Disease\n(\tO\nLV\tB-Disease\n)\tO\nis\tO\nprimarily\tO\na\tO\ncutaneous\tB-Disease\nsmall\tI-Disease\nvessel\tI-Disease\nvasculitis\tI-Disease\n,\tO\nthough\tO\nsystemic\tO\ninvolvement\tO\nmay\tO\nbe\tO\nencountered\tO\n.\tO\n\nWe\tO\nreport\tO\n4\tO\npatients\tO\nwith\tO\nlate\tO\n-\tO\nonset\tO\nLV\tB-Disease\nprobably\tO\ndue\tO\nto\tO\nwarfarin\tB-Chemical\n.\tO\n\nAll\tO\n4\tO\npatients\tO\npresented\tO\nwith\tO\nskin\tB-Disease\neruptions\tI-Disease\nthat\tO\ndeveloped\tO\nafter\tO\nreceiving\tO\nwarfarin\tB-Chemical\nfor\tO\nseveral\tO\nyears\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nskin\tB-Disease\nlesion\tI-Disease\nbiopsies\tO\nwere\tO\navailable\tO\nin\tO\n3\tO\npatients\tO\n,\tO\nconfirming\tO\nLV\tB-Disease\nCutaneous\tI-Disease\nlesions\tI-Disease\nresolved\tO\nin\tO\nall\tO\npatients\tO\nafter\tO\nwarfarin\tB-Chemical\nwas\tO\ndiscontinued\tO\n.\tO\n\nIn\tO\n2\tO\nof\tO\nthe\tO\n4\tO\npatients\tO\n,\tO\nrechallenge\tO\nwith\tO\nwarfarin\tB-Chemical\nled\tO\nto\tO\nrecurrence\tO\nof\tO\nthe\tO\nlesions\tO\n.\tO\n\nLV\tB-Disease\nmay\tO\nbe\tO\na\tO\nlate\tO\n-\tO\nonset\tO\nadverse\tO\nreaction\tO\nassociated\tO\nwith\tO\nwarfarin\tB-Chemical\ntherapy\tO\n.\tO\n\nCocaine\tB-Chemical\n-\tO\ninduced\tO\nbrainstem\tO\nseizures\tB-Disease\nand\tO\nbehavior\tO\n.\tO\n\nA\tO\nvariety\tO\nof\tO\nabnormal\tO\nsensory\tO\n/\tO\nmotor\tO\nbehaviors\tO\nassociated\tO\nwith\tO\nelectrical\tO\ndischarges\tO\nrecorded\tO\nfrom\tO\nthe\tO\nbilateral\tO\nbrainstem\tO\nwere\tO\ninduced\tO\nin\tO\nadult\tO\nWKY\tO\nrats\tO\nby\tO\nmechanical\tO\n(\tO\nelectrode\tO\nimplants\tO\n)\tO\nand\tO\nDC\tO\nelectrical\tO\ncurrent\tO\nstimulations\tO\nand\tO\nby\tO\nacute\tO\nand\tO\nchronic\tO\nadministration\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nThe\tO\nelectrode\tO\nimplant\tO\nimplicated\tO\none\tO\nside\tO\nor\tO\nthe\tO\nother\tO\nof\tO\nthe\tO\nreticular\tO\nsystem\tO\nof\tO\nthe\tO\nbrainstem\tO\nbut\tO\nsubjects\tO\nwere\tO\nnot\tO\nincapacitated\tO\nby\tO\nthe\tO\nstimulations\tO\n.\tO\n\nCocaine\tB-Chemical\n(\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ninjected\tO\nsubcutaneously\tO\nfor\tO\nan\tO\nacute\tO\nexperiment\tO\nand\tO\nsubsequent\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ndoses\tO\ntwice\tO\ndaily\tO\nfor\tO\n3\tO\ndays\tO\nin\tO\na\tO\nchronic\tO\nstudy\tO\n.\tO\n\nCocaine\tB-Chemical\ngenerated\tO\nmore\tO\nabnormal\tO\nbehaviors\tO\nin\tO\nthe\tO\nbrainstem\tO\nperturbation\tO\ngroup\tO\n,\tO\nespecially\tO\nthe\tO\nelectrically\tO\nperturbated\tO\nsubjects\tO\n.\tO\n\nThe\tO\nabnormal\tO\nbehaviors\tO\nwere\tO\nyawning\tO\n,\tO\nretrocollis\tO\n,\tO\nhyperactivity\tB-Disease\n,\tO\nhypersensitivity\tB-Disease\n,\tO\n\"\tO\nbeating\tO\ndrum\tO\n\"\tO\nbehavior\tO\n,\tO\nsquealing\tO\n,\tO\nhead\tO\nbobbing\tO\n,\tO\ncircling\tO\n,\tO\nsniffing\tO\n,\tO\nabnormal\tO\nposturing\tO\n,\tO\nand\tO\nfacial\tO\ntwitching\tO\n.\tO\n\nShifts\tO\nin\tO\nthe\tO\npower\tO\nfrequency\tO\nspectra\tO\nof\tO\nthe\tO\ndischarge\tO\npatterns\tO\nwere\tO\nnoted\tO\nbetween\tO\nquiet\tO\nand\tO\npacing\tO\nbehavioral\tO\nstates\tO\n.\tO\n\nHypersensitivity\tB-Disease\nto\tO\nvarious\tO\nauditory\tO\n,\tO\ntactile\tO\n,\tO\nand\tO\nvisual\tO\nstimulation\tO\nwas\tO\npresent\tO\nand\tO\nshifts\tO\nin\tO\nthe\tO\nbrainstem\tO\nambient\tO\npower\tO\nspectral\tO\nfrequency\tO\noccurred\tO\nin\tO\nresponse\tO\nto\tO\ntactile\tO\nstimulation\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nthe\tO\nbrainstem\tO\ngenerates\tO\nand\tO\npropagates\tO\npathological\tO\ndischarges\tO\nthat\tO\ncan\tO\nbe\tO\nelicited\tO\nby\tO\nmechanical\tO\nand\tO\nDC\tO\nelectrical\tO\nperturbation\tO\n.\tO\n\nCocaine\tB-Chemical\nwas\tO\nfound\tO\nto\tO\nactivate\tO\nthe\tO\ndischarge\tO\nsystem\tO\nand\tO\nthus\tO\ninduce\tO\nabnormal\tO\nbehaviors\tO\nthat\tO\nare\tO\ngenerated\tO\nat\tO\nthe\tO\ndischarge\tO\nsite\tO\nand\tO\nat\tO\ndistant\tO\nsites\tO\nto\tO\nwhich\tO\nthe\tO\ndischarge\tO\npropagates\tO\n.\tO\n\nCognitive\tO\nfunctions\tO\nmay\tO\nalso\tO\nbe\tO\ninvolved\tO\nsince\tO\ndopaminergic\tO\nand\tO\nserotonergic\tO\ncellular\tO\nelements\tO\nat\tO\nthe\tO\nbrainstem\tO\nlevel\tO\nare\tO\nalso\tO\nimplicated\tO\n.\tO\n\nrTMS\tO\nof\tO\nsupplementary\tO\nmotor\tO\narea\tO\nmodulates\tO\ntherapy\tO\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nin\tO\nParkinson\tB-Disease\ndisease\tI-Disease\n.\tO\n\nThe\tO\nneural\tO\nmechanisms\tO\nand\tO\ncircuitry\tO\ninvolved\tO\nin\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\nare\tO\nunclear\tO\n.\tO\n\nUsing\tO\nrepetitive\tO\ntranscranial\tO\nmagnetic\tO\nstimulation\tO\n(\tO\nrTMS\tO\n)\tO\nover\tO\nthe\tO\nsupplementary\tO\nmotor\tO\narea\tO\n(\tO\nSMA\tO\n)\tO\nin\tO\na\tO\ngroup\tO\nof\tO\npatients\tO\nwith\tO\nadvanced\tO\nParkinson\tB-Disease\ndisease\tI-Disease\n,\tO\nthe\tO\nauthors\tO\ninvestigated\tO\nwhether\tO\nmodulation\tO\nof\tO\nSMA\tO\nexcitability\tO\nmay\tO\nresult\tO\nin\tO\na\tO\nmodification\tO\nof\tO\na\tO\ndyskinetic\tB-Disease\nstate\tO\ninduced\tO\nby\tO\ncontinuous\tO\napomorphine\tB-Chemical\ninfusion\tO\n.\tO\n\nrTMS\tO\nat\tO\n1\tO\nHz\tO\nwas\tO\nobserved\tO\nto\tO\nmarkedly\tO\nreduce\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\ndyskinesias\tI-Disease\n,\tO\nwhereas\tO\n5\tO\n-\tO\nHz\tO\nrTMS\tO\ninduced\tO\na\tO\nslight\tO\nbut\tO\nnot\tO\nsignificant\tO\nincrease\tO\n.\tO\n\nIntracavitary\tO\nchemotherapy\tO\n(\tO\npaclitaxel\tB-Chemical\n/\tO\ncarboplatin\tB-Chemical\nliquid\tO\ncrystalline\tO\ncubic\tO\nphases\tO\n)\tO\nfor\tO\nrecurrent\tO\nglioblastoma\tB-Disease\n-\tO\n-\tO\nclinical\tO\nobservations\tO\n.\tO\n\nHuman\tO\nmalignant\tO\nbrain\tB-Disease\ntumors\tI-Disease\nhave\tO\na\tO\npoor\tO\nprognosis\tO\nin\tO\nspite\tO\nof\tO\nsurgery\tO\nand\tO\nradiation\tO\ntherapy\tO\n.\tO\n\nCubic\tO\nphases\tO\nconsist\tO\nof\tO\ncurved\tO\nbiocontinuous\tO\nlipid\tO\nbilayers\tO\n,\tO\nseparating\tO\ntwo\tO\ncongruent\tO\nnetworks\tO\nof\tO\nwater\tO\nchannels\tO\n.\tO\n\nUsed\tO\nas\tO\na\tO\nhost\tO\nfor\tO\ncytotoxic\tO\ndrugs\tO\n,\tO\nthe\tO\ngel\tO\n-\tO\nlike\tO\nmatrix\tO\ncan\tO\neasily\tO\nbe\tO\napplied\tO\nto\tO\nthe\tO\nwalls\tO\nof\tO\na\tO\nsurgical\tO\nresection\tO\ncavity\tO\n.\tO\n\nFor\tO\nhuman\tO\nglioblastoma\tB-Disease\nrecurrences\tO\n,\tO\nthe\tO\nfeasibility\tO\n,\tO\nsafety\tO\n,\tO\nand\tO\nshort\tO\n-\tO\nterm\tO\neffects\tO\nof\tO\na\tO\nsurgical\tO\nintracavitary\tO\napplication\tO\nof\tO\npaclitaxel\tB-Chemical\nand\tO\ncarboplatin\tB-Chemical\nencapsulated\tO\nby\tO\nliquid\tO\ncrystalline\tO\ncubic\tO\nphases\tO\nare\tO\nexamined\tO\nin\tO\na\tO\npilot\tO\nstudy\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n12\tO\npatients\tO\nwith\tO\na\tO\nrecurrence\tO\nof\tO\na\tO\nglioblastoma\tB-Disease\nmultiforme\tO\nunderwent\tO\nre\tO\n-\tO\nresection\tO\nand\tO\nreceived\tO\nan\tO\nintracavitary\tO\napplication\tO\nof\tO\npaclitaxel\tB-Chemical\nand\tO\ncarboplatin\tB-Chemical\ncubic\tO\nphases\tO\nin\tO\ndifferent\tO\ndosages\tO\n.\tO\n\nSix\tO\nof\tO\nthe\tO\npatients\tO\nreceived\tO\nmore\tO\nthan\tO\n15\tO\nmg\tO\npaclitaxel\tB-Chemical\nand\tO\nsuffered\tO\nfrom\tO\nmoderate\tO\nto\tO\nsevere\tO\nbrain\tB-Disease\nedema\tI-Disease\n,\tO\nwhile\tO\nthe\tO\nremaining\tO\npatients\tO\nreceived\tO\nonly\tO\na\tO\ntotal\tO\nof\tO\n15\tO\nmg\tO\npaclitaxel\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\nlatter\tO\ngroup\tO\n,\tO\nbrain\tB-Disease\nedema\tI-Disease\nwas\tO\nmarkedly\tO\nreduced\tO\nand\tO\ndealt\tO\nmedically\tO\n.\tO\n\nIntracavitary\tO\nchemotherapy\tO\nin\tO\nrecurrent\tO\nglioblastoma\tB-Disease\nusing\tO\ncubic\tO\nphases\tO\nis\tO\nfeasible\tO\nand\tO\nsafe\tO\n,\tO\nyet\tO\nthe\tO\nclinical\tO\nbenefit\tO\nremains\tO\nto\tO\nbe\tO\nexamined\tO\nin\tO\na\tO\nclinical\tO\nphase\tO\nII\tO\nstudy\tO\n.\tO\n\nLamotrigine\tB-Chemical\nassociated\tO\nwith\tO\nexacerbation\tO\nor\tO\nde\tO\nnovo\tO\nmyoclonus\tB-Disease\nin\tO\nidiopathic\tB-Disease\ngeneralized\tI-Disease\nepilepsies\tI-Disease\n.\tO\n\nFive\tO\npatients\tO\nwith\tO\nidiopathic\tB-Disease\ngeneralized\tI-Disease\nepilepsies\tI-Disease\n(\tO\nIGE\tB-Disease\n)\tO\ntreated\tO\nwith\tO\nlamotrigine\tB-Chemical\n(\tO\nLTG\tB-Chemical\n)\tO\nexperienced\tO\nexacerbation\tO\nor\tO\nde\tO\nnovo\tO\nappearance\tO\nof\tO\nmyoclonic\tB-Disease\njerks\tI-Disease\n(\tO\nMJ\tB-Disease\n)\tO\n.\tO\n\nIn\tO\nthree\tO\npatients\tO\n,\tO\nLTG\tB-Chemical\nexacerbated\tO\nMJ\tB-Disease\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\nwith\tO\nearly\tO\naggravation\tO\nduring\tO\ntitration\tO\n.\tO\n\nMJ\tB-Disease\ndisappeared\tO\nwhen\tO\nLTG\tB-Chemical\ndose\tO\nwas\tO\ndecreased\tO\nby\tO\n25\tO\nto\tO\n50\tO\n%\tO\n.\tO\n\nIn\tO\ntwo\tO\npatients\tO\n,\tO\nLTG\tB-Chemical\nexacerbated\tO\nMJ\tB-Disease\nin\tO\na\tO\ndelayed\tO\nbut\tO\nmore\tO\nsevere\tO\nmanner\tO\n,\tO\nwith\tO\nmyoclonic\tB-Disease\nstatus\tI-Disease\nthat\tO\nonly\tO\nceased\tO\nafter\tO\nLTG\tB-Chemical\nwithdrawal\tO\n.\tO\n\nAbsence\tO\nof\tO\nacute\tO\ncerebral\tO\nvasoconstriction\tO\nafter\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\n.\tO\n\nINTRODUCTION\tO\n:\tO\nCocaine\tB-Chemical\nuse\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nneurovascular\tB-Disease\ncomplications\tI-Disease\n,\tO\nincluding\tO\narterial\tO\nvasoconstriction\tO\nand\tO\nvasculitis\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nare\tO\nfew\tO\nstudies\tO\nof\tO\nangiographic\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\non\tO\nhuman\tO\ncerebral\tO\narteries\tO\n.\tO\n\nInformation\tO\non\tO\nthese\tO\neffects\tO\ncould\tO\nbe\tO\nobtained\tO\nfrom\tO\nangiograms\tO\nof\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\n(\tO\nSAH\tB-Disease\n)\tO\nwho\tO\nunderwent\tO\nangiography\tO\nshortly\tO\nafter\tO\ncocaine\tB-Chemical\nuse\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nscreened\tO\npatients\tO\nwith\tO\nSAH\tB-Disease\nretrospectively\tO\nand\tO\nidentified\tO\nthose\tO\nwith\tO\npositive\tO\nurine\tO\ntoxicology\tO\nfor\tO\ncocaine\tB-Chemical\nor\tO\nits\tO\nmetabolites\tO\n.\tO\n\nQuantitative\tO\narterial\tO\ndiameter\tO\nmeasurements\tO\nfrom\tO\nangiograms\tO\nof\tO\nthese\tO\npatients\tO\nwere\tO\ncompared\tO\nto\tO\nmeasurements\tO\nfrom\tO\ncontrol\tO\npatients\tO\nwith\tO\nSAH\tB-Disease\nwho\tO\nwere\tO\nmatched\tO\nfor\tO\nfactors\tO\nknown\tO\nto\tO\ninfluence\tO\narterial\tO\ndiameter\tO\n.\tO\n\nQualitative\tO\ncomparisons\tO\nof\tO\nsmall\tO\nartery\tO\nchanges\tO\nalso\tO\nwere\tO\nmade\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThirteen\tO\npatients\tO\nwith\tO\npositive\tO\ncocaine\tB-Chemical\ntoxicology\tO\nwere\tO\ncompared\tO\nto\tO\n26\tO\ncontrols\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\ngroups\tO\nin\tO\nthe\tO\nmean\tO\ndiameters\tO\nof\tO\nthe\tO\nintradural\tO\ninternal\tO\ncarotid\tO\n,\tO\nsphenoidal\tO\nsegment\tO\nof\tO\nthe\tO\nmiddle\tO\ncerebral\tO\n,\tO\nprecommunicating\tO\nsegment\tO\nof\tO\nthe\tO\nanterior\tO\ncerebral\tO\n,\tO\nor\tO\nbasilar\tO\narteries\tO\n(\tO\np\tO\ngreater\tO\nthan\tO\n0\tO\n.\tO\n05\tO\nfor\tO\nall\tO\ncomparisons\tO\n,\tO\nunpaired\tO\nt\tO\n-\tO\ntests\tO\n)\tO\n.\tO\n\nThere\tO\nalso\tO\nwere\tO\nno\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\ngroups\tO\nwhen\tO\nexpressing\tO\ndiameters\tO\nas\tO\nthe\tO\nsum\tO\nof\tO\nthe\tO\nprecommunicating\tO\nsegment\tO\nof\tO\nthe\tO\nanterior\tO\ncerebral\tO\n+\tO\nsphenoidal\tO\nsegment\tO\nof\tO\nthe\tO\nmiddle\tO\ncerebral\tO\n+\tO\nsupraclinoid\tO\ninternal\tO\ncarotid\tO\nartery\tO\n+\tO\nbasilar\tO\nartery\tO\ndivided\tO\nby\tO\nthe\tO\ndiameter\tO\nof\tO\nthe\tO\npetrous\tO\ninternal\tO\ncarotid\tO\nartery\tO\n(\tO\np\tO\ngreater\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n,\tO\nunpaired\tO\nt\tO\n-\tO\ntests\tO\n)\tO\n.\tO\n\nQualitative\tO\nassessments\tO\nshowed\tO\ntwo\tO\narterial\tO\nirregularities\tO\nin\tO\nthe\tO\ndistal\tO\nvasculature\tO\nin\tO\neach\tO\ngroup\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nNo\tO\nquantitative\tO\nevidence\tO\nfor\tO\nnarrowing\tO\nof\tO\nlarge\tO\ncerebral\tO\narteries\tO\nor\tO\nqualitative\tO\nangiographic\tO\nevidence\tO\nfor\tO\ndistal\tO\nnarrowing\tO\nor\tO\nvasculitis\tB-Disease\ncould\tO\nbe\tO\nfound\tO\nin\tO\npatients\tO\nwho\tO\nunderwent\tO\nangiography\tO\nafter\tO\naneurysmal\tB-Disease\nSAH\tB-Disease\nassociated\tO\nwith\tO\ncocaine\tB-Chemical\nuse\tO\n.\tO\n\nMethamphetamine\tB-Chemical\ncauses\tO\nalterations\tO\nin\tO\nthe\tO\nMAP\tO\nkinase\tO\n-\tO\nrelated\tO\npathways\tO\nin\tO\nthe\tO\nbrains\tO\nof\tO\nmice\tO\nthat\tO\ndisplay\tO\nincreased\tO\naggressiveness\tB-Disease\n.\tO\n\nAggressive\tB-Disease\nbehaviors\tI-Disease\nhave\tO\nbeen\tO\nreported\tO\nin\tO\npatients\tO\nwho\tO\nsuffer\tO\nfrom\tO\nsome\tO\npsychiatric\tB-Disease\ndisorders\tI-Disease\n,\tO\nand\tO\nare\tO\ncommon\tO\nin\tO\nmethamphetamine\tB-Chemical\n(\tO\nMETH\tB-Chemical\n)\tO\nabusers\tO\n.\tO\n\nHerein\tO\n,\tO\nwe\tO\nreport\tO\nthat\tO\nmultiple\tO\n(\tO\nbut\tO\nnot\tO\nsingle\tO\n)\tO\ninjections\tO\nof\tO\nMETH\tB-Chemical\nsignificantly\tO\nincreased\tO\naggressiveness\tB-Disease\nin\tO\nmale\tO\nCD\tO\n-\tO\n1\tO\nmice\tO\n.\tO\n\nThis\tO\nincrease\tO\nin\tO\naggressiveness\tB-Disease\nwas\tO\nnot\tO\nsecondary\tO\nto\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n.\tO\n\nAnalysis\tO\nof\tO\nprotein\tO\nexpression\tO\nusing\tO\nantibody\tO\nmicroarrays\tO\nand\tO\nWestern\tO\nblotting\tO\nrevealed\tO\ndifferential\tO\nchanges\tO\nin\tO\nMAP\tO\nkinase\tO\n-\tO\nrelated\tO\npathways\tO\nafter\tO\nmultiple\tO\nand\tO\nsingle\tO\nMETH\tB-Chemical\ninjections\tO\n.\tO\n\nThere\tO\nwere\tO\nstatistically\tO\nsignificant\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\ndecreases\tO\nin\tO\nMEK1\tO\n,\tO\nErk2p\tO\n,\tO\nGSK3alpha\tO\n,\tO\n14\tO\n-\tO\n3\tO\n-\tO\n3e\tO\n,\tO\nand\tO\nMEK7\tO\nin\tO\nthe\tO\nstriata\tO\nof\tO\nmice\tO\nafter\tO\nmultiple\tO\ninjections\tO\nof\tO\nMETH\tB-Chemical\n.\tO\n\nMEK1\tO\nwas\tO\nsignificantly\tO\ndecreased\tO\nalso\tO\nafter\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\nMETH\tB-Chemical\n,\tO\nbut\tO\nto\tO\na\tO\nmuch\tO\nlesser\tO\ndegree\tO\nthan\tO\nafter\tO\nmultiple\tO\ninjections\tO\nof\tO\nMETH\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\nfrontal\tO\ncortex\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nstatistically\tO\nsignificant\tO\ndecrease\tO\nin\tO\nGSK3alpha\tO\nafter\tO\nmultiple\tO\n(\tO\nbut\tO\nnot\tO\nsingle\tO\n)\tO\ninjections\tO\nof\tO\nMETH\tB-Chemical\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nalterations\tO\nin\tO\nMAP\tO\nkinase\tO\n-\tO\nrelated\tO\npathways\tO\nin\tO\nthe\tO\nprefronto\tO\n-\tO\nstriatal\tO\ncircuitries\tO\nmight\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\nmanifestation\tO\nof\tO\naggressive\tB-Disease\nbehaviors\tI-Disease\nin\tO\nmice\tO\n.\tO\n\nAmisulpride\tB-Chemical\nrelated\tO\ntic\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nsymptoms\tI-Disease\nin\tO\nan\tO\nadolescent\tO\nschizophrenic\tB-Disease\n.\tO\n\nTic\tB-Disease\ndisorders\tI-Disease\ncan\tO\nbe\tO\neffectively\tO\ntreated\tO\nby\tO\natypical\tO\nantipsychotics\tO\nsuch\tO\nas\tO\nrisperidone\tB-Chemical\n,\tO\nolanzapine\tB-Chemical\nand\tO\nziprasidone\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nare\tO\ntwo\tO\ncase\tO\nreports\tO\nthat\tO\nshow\tO\ntic\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nsymptoms\tI-Disease\n,\tO\nincluding\tO\nmotor\tO\nand\tO\nphonic\tO\nvariants\tO\n,\tO\noccurring\tO\nduring\tO\ntreatment\tO\nwith\tO\nquetiapine\tB-Chemical\nor\tO\nclozapine\tB-Chemical\n.\tO\n\nWe\tO\npresent\tO\na\tO\n15\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ngirl\tO\nschizophrenic\tB-Disease\nwho\tO\ndeveloped\tO\nfrequent\tO\ninvoluntary\tB-Disease\neye\tI-Disease\n-\tI-Disease\nblinking\tI-Disease\nmovements\tI-Disease\nafter\tO\n5\tO\nmonths\tO\nof\tO\namisulpride\tB-Chemical\ntreatment\tO\n(\tO\n1000\tO\nmg\tO\nper\tO\nday\tO\n)\tO\n.\tO\n\nThe\tO\ntic\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nsymptoms\tI-Disease\nresolved\tO\ncompletely\tO\nafter\tO\nwe\tO\nreduced\tO\nthe\tO\ndose\tO\nof\tO\namisulpride\tB-Chemical\ndown\tO\nto\tO\n800\tO\nmg\tO\nper\tO\nday\tO\n.\tO\n\nHowever\tO\n,\tO\nher\tO\npsychosis\tB-Disease\nrecurred\tO\nafter\tO\nthe\tO\ndose\tO\nreduction\tO\n.\tO\n\nWe\tO\nthen\tO\nplaced\tO\nher\tO\non\tO\nan\tO\nadditional\tO\n100\tO\nmg\tO\nper\tO\nday\tO\nof\tO\nquetiapine\tB-Chemical\n.\tO\n\nShe\tO\nhas\tO\nbeen\tO\nin\tO\ncomplete\tO\nremission\tO\nunder\tO\nthe\tO\ncombined\tO\nmedications\tO\nfor\tO\nmore\tO\nthan\tO\none\tO\nyear\tO\nand\tO\nmaintains\tO\na\tO\nfair\tO\nrole\tO\nfunction\tO\n.\tO\n\nNo\tO\nmore\tO\ntic\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nsymptoms\tI-Disease\nor\tO\nother\tO\nside\tO\neffects\tO\nhave\tO\nbeen\tO\nreported\tO\n.\tO\n\nTogether\tO\nwith\tO\npreviously\tO\nreported\tO\ncases\tO\n,\tO\nour\tO\npatient\tO\nsuggests\tO\nthat\tO\ntic\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nsymptoms\tI-Disease\nmight\tO\noccur\tO\nin\tO\ncertain\tO\nvulnerable\tO\nindividuals\tO\nduring\tO\ntreatment\tO\nwith\tO\natypical\tO\nantipsychotics\tO\nsuch\tO\nas\tO\nquetiapine\tB-Chemical\n,\tO\nclozapine\tB-Chemical\n,\tO\nor\tO\namisulpride\tB-Chemical\n.\tO\n\nChloroquine\tB-Chemical\nrelated\tO\ncomplete\tO\nheart\tB-Disease\nblock\tI-Disease\nwith\tO\nblindness\tB-Disease\n:\tO\ncase\tO\nreport\tO\n.\tO\n\nA\tO\n27\tO\n-\tO\nyear\tO\nold\tO\nAfrican\tO\nwoman\tO\nwith\tO\nhistory\tO\nof\tO\nregular\tO\nchloroquine\tB-Chemical\ningestion\tO\npresented\tO\nwith\tO\nprogressive\tO\ndeterioration\tB-Disease\nof\tI-Disease\nvision\tI-Disease\n,\tO\neasy\tO\nfatiguability\tB-Disease\n,\tO\ndyspnoea\tB-Disease\n,\tO\ndizziness\tB-Disease\nprogressing\tO\nto\tO\nsyncopal\tB-Disease\nattacks\tI-Disease\n.\tO\n\nOphthalmological\tO\nassessment\tO\nrevealed\tO\nfeatures\tO\nof\tO\nchloroquine\tB-Chemical\nretinopathy\tB-Disease\n,\tO\ncardiac\tO\nassessment\tO\nrevealed\tO\nfeatures\tO\nof\tO\nheart\tB-Disease\nfailure\tI-Disease\nand\tO\na\tO\ncomplete\tO\nheart\tB-Disease\nblock\tI-Disease\nwith\tO\nright\tB-Disease\nbundle\tI-Disease\nbranch\tI-Disease\nblock\tI-Disease\npattern\tO\n.\tO\n\nThe\tO\nheart\tB-Disease\nblock\tI-Disease\nwas\tO\ntreated\tO\nby\tO\npacemaker\tO\ninsertion\tO\nand\tO\nthe\tO\nheart\tB-Disease\nfailure\tI-Disease\nresolved\tO\nspontaneously\tO\nfollowing\tO\nchloroquine\tB-Chemical\ndiscontinuation\tO\n.\tO\n\nShe\tO\nhowever\tO\nremains\tO\nblind\tB-Disease\n.\tO\n\nEffects\tO\nof\tO\nsuprofen\tB-Chemical\non\tO\nthe\tO\nisolated\tO\nperfused\tO\nrat\tO\nkidney\tO\n.\tO\n\nAlthough\tO\nsuprofen\tB-Chemical\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nin\tO\ngreater\tO\nthan\tO\n100\tO\nsubjects\tO\n,\tO\nthe\tO\nmechanism\tO\nof\tO\ndamage\tO\nremains\tO\nunclear\tO\n.\tO\n\nThe\tO\ndirect\tO\nnephrotoxic\tB-Disease\neffects\tO\nof\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\n15\tO\nmg\tO\nof\tO\nsuprofen\tB-Chemical\nwere\tO\ncompared\tO\nin\tO\nthe\tO\nrecirculating\tO\nisolated\tO\nrat\tO\nkidney\tO\nperfused\tO\nwith\tO\ncell\tO\n-\tO\nfree\tO\nbuffer\tO\nwith\tO\nor\tO\nwithout\tO\nthe\tO\naddition\tO\nof\tO\n5\tO\nmg\tO\n/\tO\ndL\tO\nof\tO\nuric\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nsignificant\tO\ndifferences\tO\nin\tO\nrenal\tO\nsodium\tB-Chemical\nexcretion\tO\n,\tO\noxygen\tB-Chemical\nconsumption\tO\n,\tO\nor\tO\nurinary\tO\nflow\tO\nrates\tO\nin\tO\nkidneys\tO\nperfused\tO\nwith\tO\nsuprofen\tB-Chemical\ncompared\tO\nwith\tO\nthe\tO\ndrug\tO\n-\tO\nfree\tO\ncontrol\tO\ngroups\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\na\tO\nsignificant\tO\ndecline\tO\nin\tO\nglomerular\tO\nfiltration\tO\nrate\tO\nwas\tO\nfound\tO\nafter\tO\nthe\tO\nintroduction\tO\nof\tO\nsuprofen\tB-Chemical\nto\tO\nthe\tO\nkidney\tO\nperfused\tO\nwith\tO\nuric\tB-Chemical\nacid\tI-Chemical\n;\tO\nno\tO\nchanges\tO\nwere\tO\nfound\tO\nwith\tO\nsuprofen\tB-Chemical\nin\tO\nthe\tO\nabsence\tO\nof\tO\nuric\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nA\tO\nsignificant\tO\ndecrease\tO\nin\tO\nthe\tO\nbaseline\tO\nexcretion\tO\nrate\tO\nof\tO\nuric\tB-Chemical\nacid\tI-Chemical\nwas\tO\nfound\tO\nin\tO\nrats\tO\ngiven\tO\nsuprofen\tB-Chemical\n,\tO\ncompared\tO\nwith\tO\ndrug\tO\n-\tO\nfree\tO\ncontrols\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nfractional\tO\nexcretion\tO\nof\tO\nuric\tB-Chemical\nacid\tI-Chemical\nwas\tO\nunchanged\tO\nbetween\tO\nthe\tO\ngroups\tO\nover\tO\nthe\tO\nexperimental\tO\nperiod\tO\n.\tO\n\nIn\tO\nsummary\tO\n,\tO\nsuprofen\tB-Chemical\ncauses\tO\nacute\tB-Disease\ndeclines\tI-Disease\nin\tI-Disease\nrenal\tI-Disease\nfunction\tI-Disease\n,\tO\nmost\tO\nlikely\tO\nby\tO\ndirectly\tO\naltering\tO\nthe\tO\nintrarenal\tO\ndistribution\tO\nof\tO\nuric\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nMicroinjection\tO\nof\tO\nritanserin\tB-Chemical\ninto\tO\nthe\tO\nCA1\tO\nregion\tO\nof\tO\nhippocampus\tO\nimproves\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\nin\tO\nadult\tO\nmale\tO\nrats\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nritanserin\tB-Chemical\n(\tO\n5\tO\n-\tO\nHT2\tO\nantagonist\tO\n)\tO\non\tO\nscopolamine\tB-Chemical\n(\tO\nmuscarinic\tO\ncholinergic\tO\nantagonist\tO\n)\tO\n-\tO\ninduced\tO\namnesia\tB-Disease\nin\tO\nMorris\tO\nwater\tO\nmaze\tO\n(\tO\nMWM\tO\n)\tO\nwas\tO\ninvestigated\tO\n.\tO\n\nRats\tO\nwere\tO\ndivided\tO\ninto\tO\neight\tO\ngroups\tO\nand\tO\nbilaterally\tO\ncannulated\tO\ninto\tO\nCA1\tO\nregion\tO\nof\tO\nthe\tO\nhippocampus\tO\n.\tO\n\nOne\tO\nweek\tO\nlater\tO\n,\tO\nthey\tO\nreceived\tO\nrepeatedly\tO\nvehicles\tO\n(\tO\nsaline\tO\n,\tO\nDMSO\tB-Chemical\n,\tO\nsaline\tO\n+\tO\nDMSO\tB-Chemical\n)\tO\n,\tO\nscopolamine\tB-Chemical\n(\tO\n2\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\nsaline\tO\n/\tO\nside\tO\n;\tO\n30\tO\nmin\tO\nbefore\tO\ntraining\tO\n)\tO\n,\tO\nritanserin\tB-Chemical\n(\tO\n2\tO\n,\tO\n4\tO\nand\tO\n8\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\nDMSO\tB-Chemical\n/\tO\nside\tO\n;\tO\n20\tO\nmin\tO\nbefore\tO\ntraining\tO\n)\tO\nand\tO\nscopolamine\tB-Chemical\n(\tO\n2\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\n;\tO\n30\tO\nmin\tO\nbefore\tO\nritanserin\tB-Chemical\ninjection\tO\n)\tO\n+\tO\nritanserin\tB-Chemical\n(\tO\n4\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\nDMSO\tB-Chemical\n)\tO\nthrough\tO\ncannulae\tO\neach\tO\nday\tO\n.\tO\n\nAnimals\tO\nwere\tO\ntested\tO\nfor\tO\nfour\tO\nconsecutive\tO\ndays\tO\n(\tO\n4\tO\ntrial\tO\n/\tO\nday\tO\n)\tO\nin\tO\nMWM\tO\nduring\tO\nwhich\tO\nthe\tO\nposition\tO\nof\tO\nhidden\tO\nplatform\tO\nwas\tO\nunchanged\tO\n.\tO\n\nIn\tO\nthe\tO\nfifth\tO\nday\tO\n,\tO\nthe\tO\nplatform\tO\nwas\tO\nelevated\tO\nabove\tO\nthe\tO\nwater\tO\nsurface\tO\nin\tO\nanother\tO\nposition\tO\nto\tO\nevaluate\tO\nthe\tO\nfunction\tO\nof\tO\nmotor\tO\n,\tO\nmotivational\tO\nand\tO\nvisual\tO\nsystems\tO\n.\tO\n\nThe\tO\nresults\tO\nshowed\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nescape\tO\nlatencies\tO\nand\tO\ntraveled\tO\ndistances\tO\nto\tO\nfind\tO\nplatform\tO\nin\tO\nscopolamine\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\nas\tO\ncompared\tO\nto\tO\nsaline\tO\ngroup\tO\n.\tO\n\nRitanserin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n(\tO\n4\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\n/\tO\nside\tO\n)\tO\nshowed\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nthe\tO\nmentioned\tO\nparameters\tO\nas\tO\ncompared\tO\nto\tO\nDMSO\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\n.\tO\n\nHowever\tO\n,\tO\nscopolamine\tB-Chemical\nand\tO\nritanserin\tB-Chemical\nco\tO\n-\tO\nadministration\tO\nresulted\tO\nin\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nescape\tO\nlatencies\tO\nand\tO\ntraveled\tO\ndistances\tO\nas\tO\ncompared\tO\nto\tO\nthe\tO\nscopolamine\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nOur\tO\nfindings\tO\nshow\tO\nthat\tO\nmicroinjection\tO\nof\tO\nritanserin\tB-Chemical\ninto\tO\nthe\tO\nCA1\tO\nregion\tO\nof\tO\nthe\tO\nhippocampus\tO\nimproves\tO\nthe\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\n.\tO\n\nPTU\tB-Chemical\n-\tO\nassociated\tO\nvasculitis\tB-Disease\nin\tO\na\tO\ngirl\tO\nwith\tO\nTurner\tB-Disease\nSyndrome\tI-Disease\nand\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\n.\tO\n\nPalpable\tO\npurpura\tB-Disease\nis\tO\na\tO\nconcerning\tO\nclinical\tO\nfinding\tO\nin\tO\npediatric\tO\npatients\tO\nand\tO\ncan\tO\nhave\tO\nmany\tO\ncauses\tO\n,\tO\nincluding\tO\ninfectious\tO\nand\tO\nautoimmune\tO\nprocesses\tO\n.\tO\n\nA\tO\nrare\tO\ncause\tO\n,\tO\ndrug\tO\n-\tO\ninduced\tO\nvasculitis\tB-Disease\n,\tO\nmay\tO\nresult\tO\nfrom\tO\nthe\tO\nproduction\tO\nof\tO\nantineutrophil\tO\ncytoplasmic\tO\nantibodies\tO\n(\tO\nANCAs\tO\n)\tO\nin\tO\nresponse\tO\nto\tO\na\tO\nmedication\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ngirl\tO\nwith\tO\nTurner\tB-Disease\nsyndrome\tI-Disease\nand\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\nwho\tO\npresented\tO\nwith\tO\npalpable\tO\npurpuric\tB-Disease\nlesions\tI-Disease\n.\tO\n\nThe\tO\ndiagnosis\tO\nof\tO\npropylthiouracil\tB-Chemical\n(\tO\nPTU\tB-Chemical\n)\tO\n-\tO\nassociated\tO\nvasculitis\tB-Disease\nwas\tO\nmade\tO\nby\tO\nobservation\tO\nof\tO\nconsistent\tO\nclinical\tO\nfeatures\tO\n,\tO\nthe\tO\ndetection\tO\nof\tO\nelevated\tO\nANA\tO\nand\tO\nANCA\tO\nin\tO\nthe\tO\nblood\tO\n,\tO\nand\tO\nthe\tO\nobserved\tO\nclinical\tO\nresolution\tO\nof\tO\nsymptoms\tO\nfollowing\tO\nwithdrawal\tO\nof\tO\nPTU\tB-Chemical\n.\tO\n\nSubsequent\tO\ntreatment\tO\nof\tO\npersistent\tO\nhyperthyroidism\tB-Disease\nwith\tO\nradioablation\tO\ndid\tO\nnot\tO\nresult\tO\nin\tO\nan\tO\nexacerbation\tO\nof\tO\nthe\tO\nvasculitis\tB-Disease\n,\tO\na\tO\ncomplication\tO\ndescribed\tO\nin\tO\nprior\tO\ncase\tO\nreports\tO\n.\tO\n\nDaidzein\tB-Chemical\nactivates\tO\ncholine\tB-Chemical\nacetyltransferase\tO\nfrom\tO\nMC\tO\n-\tO\nIXC\tO\ncells\tO\nand\tO\nimproves\tO\ndrug\tO\n-\tO\ninduced\tO\namnesia\tB-Disease\n.\tO\n\nThe\tO\ncholine\tB-Chemical\nacetyltransferase\tO\n(\tO\nChAT\tO\n)\tO\nactivator\tO\n,\tO\nwhich\tO\nenhances\tO\ncholinergic\tO\ntransmission\tO\nvia\tO\nan\tO\naugmentation\tO\nof\tO\nthe\tO\nenzymatic\tO\nproduction\tO\nof\tO\nacetylcholine\tB-Chemical\n(\tO\nACh\tB-Chemical\n)\tO\n,\tO\nis\tO\nan\tO\nimportant\tO\nfactor\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nAD\tB-Disease\n)\tO\n.\tO\n\nMethanolic\tO\nextracts\tO\nfrom\tO\nPueraria\tO\nthunbergiana\tO\nexhibited\tO\nan\tO\nactivation\tO\neffect\tO\n(\tO\n46\tO\n%\tO\n)\tO\non\tO\nChAT\tO\nin\tO\nvitro\tO\n.\tO\n\nVia\tO\nthe\tO\nsequential\tO\nisolation\tO\nof\tO\nPueraria\tO\nthunbergiana\tO\n,\tO\nthe\tO\nactive\tO\ncomponent\tO\nwas\tO\nultimately\tO\nidentified\tO\nas\tO\ndaidzein\tB-Chemical\n(\tO\n4\tB-Chemical\n'\tI-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\ndihydroxy\tI-Chemical\n-\tI-Chemical\nisoflavone\tI-Chemical\n)\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\ndaidzein\tB-Chemical\nfrom\tO\nPueraria\tO\nthunbergiana\tO\non\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\nimpairments\tB-Disease\nof\tI-Disease\nlearning\tI-Disease\nand\tI-Disease\nmemory\tI-Disease\n,\tO\nwe\tO\nconducted\tO\na\tO\nseries\tO\nof\tO\nin\tO\nvivo\tO\ntests\tO\n.\tO\n\nAdministration\tO\nof\tO\ndaidzein\tB-Chemical\n(\tO\n4\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n)\tO\nto\tO\nmice\tO\nwas\tO\nshown\tO\nsignificantly\tO\nto\tO\nreverse\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\n,\tO\naccording\tO\nto\tO\nthe\tO\nresults\tO\nof\tO\na\tO\nY\tO\n-\tO\nmaze\tO\ntest\tO\n.\tO\n\nInjections\tO\nof\tO\nscopolamine\tB-Chemical\ninto\tO\nmice\tO\nresulted\tO\nin\tO\nimpaired\tO\nperformance\tO\non\tO\nY\tO\n-\tO\nmaze\tO\ntests\tO\n(\tO\na\tO\n37\tO\n%\tO\ndecreases\tO\nin\tO\nalternation\tO\nbehavior\tO\n)\tO\n.\tO\n\nBy\tO\nway\tO\nof\tO\ncontrast\tO\n,\tO\nmice\tO\ntreated\tO\nwith\tO\ndaidzein\tB-Chemical\nprior\tO\nto\tO\nthe\tO\nscopolamine\tB-Chemical\ninjections\tO\nwere\tO\nnoticeably\tO\nprotected\tO\nfrom\tO\nthis\tO\nperformance\tO\nimpairment\tO\n(\tO\nan\tO\napproximately\tO\n12\tO\n%\tO\n-\tO\n21\tO\n%\tO\ndecrease\tO\nin\tO\nalternation\tO\nbehavior\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\ndaidzein\tB-Chemical\nmight\tO\nplay\tO\na\tO\nrole\tO\nin\tO\nacetylcholine\tB-Chemical\nbiosynthesis\tO\nas\tO\na\tO\nChAT\tO\nactivator\tO\n,\tO\nand\tO\nthat\tO\nit\tO\nalso\tO\nameliorates\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\n.\tO\n\nUrinary\tO\nsymptoms\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\nchanges\tO\nin\tO\nThai\tO\nwomen\tO\nwith\tO\noveractive\tB-Disease\nbladder\tI-Disease\nafter\tO\ntolterodine\tB-Chemical\ntreatment\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nstudy\tO\nthe\tO\nurinary\tO\nsymptoms\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\nchanges\tO\nin\tO\nThai\tO\nwomen\tO\nwith\tO\noveractive\tB-Disease\nbladder\tI-Disease\n(\tO\nOAB\tB-Disease\n)\tO\nafter\tO\ntolterodine\tB-Chemical\ntreatment\tO\n.\tO\n\nMATERIAL\tO\nAND\tO\nMETHOD\tO\n:\tO\nThirty\tO\nwomen\tO\n(\tO\naged\tO\n30\tO\n-\tO\n77\tO\nyears\tO\n)\tO\ndiagnosed\tO\nas\tO\nhaving\tO\nOAB\tB-Disease\nat\tO\nthe\tO\nGynecology\tO\nClinic\tO\n,\tO\nKing\tO\nChulalongkorn\tO\nMemorial\tO\nHospital\tO\nfrom\tO\nJanuary\tO\nto\tO\nApril\tO\n2004\tO\nwere\tO\nincluded\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\n.\tO\n\nTolterodine\tB-Chemical\n2\tO\nmg\tO\n,\tO\ntwice\tO\ndaily\tO\nwas\tO\ngiven\tO\n.\tO\n\nAfter\tO\n8\tO\nweeks\tO\ntreatment\tO\n,\tO\nchanges\tO\nin\tO\nmicturition\tO\ndiary\tO\nvariables\tO\nand\tO\ntolerability\tO\nwere\tO\ndetermined\tO\n.\tO\n\nShort\tO\nform\tO\n36\tO\n(\tO\nSF36\tO\n)\tO\nquestionaires\tO\n(\tO\nThai\tO\nversion\tO\n)\tO\nwere\tO\ngiven\tO\nbefore\tO\nand\tO\nafter\tO\n8\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAt\tO\n8\tO\nweeks\tO\n,\tO\nall\tO\nmicturition\tO\nper\tO\nday\tO\ndecreased\tO\nfrom\tO\n16\tO\n.\tO\n\n7\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n\n3\tO\nto\tO\n6\tO\n.\tO\n\n7\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n4\tO\ntimes\tO\nper\tO\nday\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\nnocturia\tB-Disease\nepisodes\tO\ndecreased\tO\nfrom\tO\n5\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n2\tO\nto\tO\n1\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n0\tO\ntimes\tO\nper\tO\nnight\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nside\tO\neffect\tO\nwas\tO\ndry\tB-Disease\nmonth\tI-Disease\nin\tO\n5\tO\ncases\tO\n(\tO\n16\tO\n.\tO\n7\tO\n%\tO\n)\tO\nwith\tO\n2\tO\ncases\tO\nreporting\tO\na\tO\nmoderate\tO\ndegree\tO\nand\tO\n1\tO\ncase\tO\nwith\tO\nsevere\tO\ndegree\tO\n.\tO\n\nOnly\tO\none\tO\ncase\tO\n(\tO\n3\tO\n.\tO\n3\tO\n%\tO\n)\tO\nwithdrew\tO\nfrom\tO\nthe\tO\npresent\tO\nstudy\tO\ndue\tO\nto\tO\na\tO\nsevere\tO\ndry\tB-Disease\nmouth\tI-Disease\n.\tO\n\nThe\tO\nSF\tO\n-\tO\n36\tO\nscores\tO\nchanged\tO\nsignificantly\tO\nin\tO\nthe\tO\ndomains\tO\nof\tO\nphysical\tO\nfunctioning\tO\n,\tO\nrole\tO\nfunction\tO\nemotional\tO\n,\tO\nsocial\tO\nfunction\tO\nand\tO\nmental\tO\nheath\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nTolterodine\tB-Chemical\nwas\tO\nwell\tO\ntolerated\tO\nand\tO\nits\tO\neffects\tO\nimproved\tO\nthe\tO\nquality\tO\nof\tO\nlife\tO\nin\tO\nThai\tO\nwomen\tO\nwith\tO\nOAB\tB-Disease\n.\tO\n\nRemifentanil\tB-Chemical\npretreatment\tO\nreduces\tO\nmyoclonus\tB-Disease\nafter\tO\netomidate\tB-Chemical\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nThe\tO\naim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\ncompare\tO\nthe\tO\neffect\tO\nof\tO\npretreatment\tO\nwith\tO\nremifentanil\tB-Chemical\n1\tO\nmicrog\tO\n/\tO\nkg\tO\nand\tO\nthe\tO\neffect\tO\nof\tO\ngender\tO\non\tO\nthe\tO\nincidence\tO\nof\tO\nmyoclonus\tB-Disease\nafter\tO\nanesthesia\tO\ninduction\tO\nwith\tO\netomidate\tB-Chemical\n.\tO\n\nDESIGN\tO\n:\tO\nThis\tO\nwas\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\n.\tO\n\nSETTING\tO\n:\tO\nThe\tO\nstudy\tO\nwas\tO\nconducted\tO\nat\tO\na\tO\nuniversity\tO\nhospital\tO\n.\tO\n\nPATIENTS\tO\n:\tO\nSixty\tO\npatients\tO\nwere\tO\npretreated\tO\nin\tO\na\tO\nrandomized\tO\ndouble\tO\n-\tO\nblinded\tO\nfashion\tO\nwith\tO\nremifentanil\tB-Chemical\n1\tO\nmicrog\tO\n/\tO\nkg\tO\nor\tO\nplacebo\tO\n.\tO\n\nTwo\tO\nminutes\tO\nafter\tO\nremifentanil\tB-Chemical\nor\tO\nplacebo\tO\ninjection\tO\n,\tO\netomidate\tB-Chemical\n0\tO\n.\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\nwas\tO\ngiven\tO\n.\tO\n\nMEASUREMENTS\tO\n:\tO\nMyoclonus\tB-Disease\nwas\tO\nrecorded\tO\nwith\tO\na\tO\nscale\tO\nof\tO\n0\tO\nto\tO\n3\tO\n.\tO\n\nThe\tO\ngrade\tO\nof\tO\nsedation\tO\n(\tO\nnone\tO\n,\tO\nmild\tO\n,\tO\nmoderate\tO\n,\tO\nsevere\tO\n)\tO\n,\tO\nnausea\tB-Disease\n,\tO\npruritus\tB-Disease\n,\tO\nand\tO\napnea\tB-Disease\nwere\tO\nrecorded\tO\nafter\tO\ninjection\tO\nof\tO\nboth\tO\ndrugs\tO\n.\tO\n\nMAIN\tO\nRESULTS\tO\n:\tO\nThe\tO\nincidence\tO\nof\tO\nmyoclonus\tB-Disease\nwas\tO\nsignificantly\tO\nlower\tO\nin\tO\nthe\tO\nremifentanil\tB-Chemical\ngroup\tO\n(\tO\n6\tO\n.\tO\n7\tO\n%\tO\n)\tO\nthan\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\n(\tO\n70\tO\n%\tO\n)\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\npatients\tO\nexperienced\tO\nsedation\tO\n,\tO\napnea\tB-Disease\n,\tO\nnausea\tB-Disease\n,\tO\nor\tO\npruritus\tB-Disease\nafter\tO\ninjection\tO\nof\tO\nboth\tO\ndrugs\tO\n.\tO\n\nIn\tO\nthe\tO\nplacebo\tO\ngroup\tO\n,\tO\nmale\tO\npatients\tO\nwere\tO\nassociated\tO\nwith\tO\nsignificantly\tO\nincreased\tO\nincidence\tO\nof\tO\nmyoclonus\tB-Disease\nafter\tO\netomidate\tB-Chemical\nadministration\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nPretreatment\tO\nwith\tO\nremifentanil\tB-Chemical\n1\tO\nmicrog\tO\n/\tO\nkg\tO\nreduced\tO\nmyoclonus\tB-Disease\nafter\tO\netomidate\tB-Chemical\ninduction\tO\nwithout\tO\nside\tO\neffects\tO\nsuch\tO\nas\tO\nsedation\tO\n,\tO\napnea\tB-Disease\n,\tO\nnausea\tB-Disease\n,\tO\nor\tO\npruritus\tB-Disease\n.\tO\n\nMen\tO\nexperience\tO\nincreased\tO\nincidence\tO\nof\tO\nmyoclonus\tB-Disease\nthan\tO\nwomen\tO\nafter\tO\netomidate\tB-Chemical\nadministration\tO\n.\tO\n\nMemory\tO\nfunction\tO\nand\tO\nserotonin\tB-Chemical\ntransporter\tO\npromoter\tO\ngene\tO\npolymorphism\tO\nin\tO\necstasy\tB-Chemical\n(\tO\nMDMA\tB-Chemical\n)\tO\nusers\tO\n.\tO\n\nAlthough\tO\n3\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethylenedioxymethamphetamine\tI-Chemical\n(\tO\nMDMA\tB-Chemical\nor\tO\necstasy\tB-Chemical\n)\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\ndamage\tO\nbrain\tO\nserotonin\tB-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n)\tO\nneurons\tO\nin\tO\nanimals\tO\nand\tO\npossibly\tO\nhumans\tO\n,\tO\nlittle\tO\nis\tO\nknown\tO\nabout\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nconsequences\tO\nof\tO\nMDMA\tB-Chemical\n-\tO\ninduced\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\nneurotoxic\tB-Disease\nlesions\tI-Disease\non\tO\nfunctions\tO\nin\tO\nwhich\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\nis\tO\ninvolved\tO\n,\tO\nsuch\tO\nas\tO\ncognitive\tO\nfunction\tO\n.\tO\n\nBecause\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\ntransporters\tO\nplay\tO\na\tO\nkey\tO\nelement\tO\nin\tO\nthe\tO\nregulation\tO\nof\tO\nsynaptic\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\ntransmission\tO\nit\tO\nmay\tO\nbe\tO\nimportant\tO\nto\tO\ncontrol\tO\nfor\tO\nthe\tO\npotential\tO\ncovariance\tO\neffect\tO\nof\tO\na\tO\npolymorphism\tO\nin\tO\nthe\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\ntransporter\tO\npromoter\tO\ngene\tO\nregion\tO\n(\tO\n5\tO\n-\tO\nHTTLPR\tO\n)\tO\nwhen\tO\nstudying\tO\nthe\tO\neffects\tO\nof\tO\nMDMA\tB-Chemical\nas\tO\nwell\tO\nas\tO\ncognitive\tO\nfunctioning\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\nmoderate\tO\nand\tO\nheavy\tO\nMDMA\tB-Chemical\nuse\tO\non\tO\ncognitive\tO\nfunction\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\neffects\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nabstention\tO\nfrom\tO\nMDMA\tB-Chemical\n,\tO\nin\tO\nsubjects\tO\ngenotyped\tO\nfor\tO\n5\tO\n-\tO\nHTTLPR\tO\n.\tO\n\nA\tO\nsecond\tO\naim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nwhether\tO\nthese\tO\neffects\tO\ndiffer\tO\nfor\tO\nfemales\tO\nand\tO\nmales\tO\n.\tO\n\nFifteen\tO\nmoderate\tO\nMDMA\tB-Chemical\nusers\tO\n(\tO\n<\tO\n55\tO\nlifetime\tO\ntablets\tO\n)\tO\n,\tO\n22\tO\nheavy\tO\nMDMA\tB-Chemical\n+\tO\nusers\tO\n(\tO\n>\tO\n55\tO\nlifetime\tO\ntablets\tO\n)\tO\n,\tO\n16\tO\nex\tO\n-\tO\nMDMA\tB-Chemical\n+\tO\nusers\tO\n(\tO\nlast\tO\ntablet\tO\n>\tO\n1\tO\nyear\tO\nago\tO\n)\tO\nand\tO\n13\tO\ncontrols\tO\nwere\tO\ncompared\tO\non\tO\na\tO\nbattery\tO\nof\tO\nneuropsychological\tO\ntests\tO\n.\tO\n\nDNA\tO\nfrom\tO\nperipheral\tO\nnuclear\tO\nblood\tO\ncells\tO\nwas\tO\ngenotyped\tO\nfor\tO\n5\tO\n-\tO\nHTTLPR\tO\nusing\tO\nstandard\tO\npolymerase\tO\nchain\tO\nreaction\tO\nmethods\tO\n.\tO\nA\tO\nsignificant\tO\ngroup\tO\neffect\tO\nwas\tO\nobserved\tO\nonly\tO\non\tO\nmemory\tO\nfunction\tO\ntasks\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n04\tO\n)\tO\nbut\tO\nnot\tO\non\tO\nreaction\tO\ntimes\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n61\tO\n)\tO\nor\tO\nattention\tO\n/\tO\nexecutive\tO\nfunctioning\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n59\tO\n)\tO\n.\tO\n\nHeavy\tO\nand\tO\nex\tO\n-\tO\nMDMA\tB-Chemical\n+\tO\nusers\tO\nperformed\tO\nsignificantly\tO\npoorer\tO\non\tO\nmemory\tO\ntasks\tO\nthan\tO\ncontrols\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nno\tO\nevidence\tO\nof\tO\nmemory\tB-Disease\nimpairment\tI-Disease\nwas\tO\nobserved\tO\nin\tO\nmoderate\tO\nMDMA\tB-Chemical\nusers\tO\n.\tO\n\nNo\tO\nsignificant\tO\neffect\tO\nof\tO\n5\tO\n-\tO\nHTTLPR\tO\nor\tO\ngender\tO\nwas\tO\nobserved\tO\n.\tO\n\nWhile\tO\nthe\tO\nuse\tO\nof\tO\nMDMA\tB-Chemical\nin\tO\nquantities\tO\nthat\tO\nmay\tO\nbe\tO\nconsidered\tO\n\"\tO\nmoderate\tO\n\"\tO\nis\tO\nnot\tO\nassociated\tO\nwith\tO\nimpaired\tB-Disease\nmemory\tI-Disease\nfunctioning\tI-Disease\n,\tO\nheavy\tO\nuse\tO\nof\tO\nMDMA\tB-Chemical\nuse\tO\nmay\tO\nlead\tO\nto\tO\nlong\tO\nlasting\tO\nmemory\tB-Disease\nimpairments\tI-Disease\n.\tO\n\nNo\tO\neffect\tO\nof\tO\n5\tO\n-\tO\nHTTLPR\tO\nor\tO\ngender\tO\non\tO\nmemory\tO\nfunction\tO\nor\tO\nMDMA\tB-Chemical\nuse\tO\nwas\tO\nobserved\tO\n.\tO\n\nRole\tO\nof\tO\nmangiferin\tB-Chemical\non\tO\nbiochemical\tO\nalterations\tO\nand\tO\nantioxidant\tO\nstatus\tO\nin\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\ncurrent\tO\nstudy\tO\ndealt\tO\nwith\tO\nthe\tO\nprotective\tO\nrole\tO\nof\tO\nmangiferin\tB-Chemical\n,\tO\na\tO\npolyphenol\tB-Chemical\nfrom\tO\nMangifera\tO\nindica\tO\nLinn\tO\n.\tO\n\n(\tO\nAnacardiaceae\tO\n)\tO\n,\tO\non\tO\nisoproterenol\tB-Chemical\n(\tO\nISPH\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n(\tO\nMI\tB-Disease\n)\tO\nin\tO\nrats\tO\nthrough\tO\nits\tO\nantioxidative\tO\nmechanism\tO\n.\tO\n\nSubcutaneous\tO\ninjection\tO\nof\tO\nISPH\tB-Chemical\n(\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\nin\tO\n1\tO\nml\tO\nsaline\tO\n)\tO\nto\tO\nrats\tO\nfor\tO\n2\tO\nconsecutive\tO\ndays\tO\ncaused\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nin\tO\nrat\tO\nheart\tO\n,\tO\nwhich\tO\nwas\tO\ndetermined\tO\nby\tO\nthe\tO\nincreased\tO\nactivity\tO\nof\tO\nserum\tO\nlactate\tB-Chemical\ndehydrogenase\tO\n(\tO\nLDH\tO\n)\tO\nand\tO\ncreatine\tB-Chemical\nphosphokinase\tO\nisoenzymes\tO\n(\tO\nCK\tO\n-\tO\nMB\tO\n)\tO\n,\tO\nincreased\tO\nuric\tB-Chemical\nacid\tI-Chemical\nlevel\tO\nand\tO\nreduced\tO\nplasma\tO\niron\tB-Chemical\nbinding\tO\ncapacity\tO\n.\tO\n\nThe\tO\nprotective\tO\nrole\tO\nof\tO\nmangiferin\tB-Chemical\nwas\tO\nanalyzed\tO\nby\tO\ntriphenyl\tB-Chemical\ntetrazolium\tI-Chemical\nchloride\tI-Chemical\n(\tO\nTTC\tB-Chemical\n)\tO\ntest\tO\nused\tO\nfor\tO\nmacroscopic\tO\nenzyme\tO\nmapping\tO\nassay\tO\nof\tO\nthe\tO\nischemic\tB-Disease\nmyocardium\tI-Disease\n.\tO\n\nThe\tO\nheart\tO\ntissue\tO\nantioxidant\tO\nenzymes\tO\nsuch\tO\nas\tO\nsuperoxide\tB-Chemical\ndismutase\tO\n,\tO\ncatalase\tO\n,\tO\nglutathione\tB-Chemical\nperoxidase\tO\n,\tO\nglutathione\tB-Chemical\ntransferase\tO\nand\tO\nglutathione\tB-Chemical\nreductase\tO\nactivities\tO\n,\tO\nnon\tO\n-\tO\nenzymic\tO\nantioxidants\tO\nsuch\tO\nas\tO\ncerruloplasmin\tO\n,\tO\nVitamin\tB-Chemical\nC\tI-Chemical\n,\tO\nVitamin\tB-Chemical\nE\tI-Chemical\nand\tO\nglutathione\tB-Chemical\nlevels\tO\nwere\tO\naltered\tO\nin\tO\nMI\tB-Disease\nrats\tO\n.\tO\n\nUpon\tO\npretreatment\tO\nwith\tO\nmangiferin\tB-Chemical\n(\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\nsuspended\tO\nin\tO\n2\tO\nml\tO\nof\tO\ndimethyl\tB-Chemical\nsulphoxide\tI-Chemical\n)\tO\ngiven\tO\nintraperitoneally\tO\nfor\tO\n28\tO\ndays\tO\nto\tO\nMI\tB-Disease\nrats\tO\nprotected\tO\nthe\tO\nabove\tO\n-\tO\nmentioned\tO\nparameters\tO\nto\tO\nfall\tO\nfrom\tO\nthe\tO\nnormal\tO\nlevels\tO\n.\tO\n\nActivities\tO\nof\tO\nheart\tO\ntissue\tO\nenzymic\tO\nantioxidants\tO\nand\tO\nserum\tO\nnon\tO\n-\tO\nenzymic\tO\nantioxidants\tO\nlevels\tO\nrose\tO\nsignificantly\tO\nupon\tO\nmangiferin\tB-Chemical\nadministration\tO\nas\tO\ncompared\tO\nto\tO\nISPH\tB-Chemical\n-\tO\ninduced\tO\nMI\tB-Disease\nrats\tO\n.\tO\n\nFrom\tO\nthe\tO\npresent\tO\nstudy\tO\nit\tO\nis\tO\nconcluded\tO\nthat\tO\nmangiferin\tB-Chemical\nexerts\tO\na\tO\nbeneficial\tO\neffect\tO\nagainst\tO\nISPH\tB-Chemical\n-\tO\ninduced\tO\nMI\tB-Disease\ndue\tO\nto\tO\nits\tO\nantioxidant\tO\npotential\tO\n,\tO\nwhich\tO\nregulated\tO\nthe\tO\ntissues\tO\ndefense\tO\nsystem\tO\nagainst\tO\ncardiac\tB-Disease\ndamage\tI-Disease\n.\tO\n\nCardiovascular\tO\nrisk\tO\nwith\tO\ncyclooxygenase\tB-Chemical\ninhibitors\tI-Chemical\n:\tO\ngeneral\tO\nproblem\tO\nwith\tO\nsubstance\tO\nspecific\tO\ndifferences\tO\n?\tO\n\nRandomised\tO\nclinical\tO\ntrials\tO\nand\tO\nobservational\tO\nstudies\tO\nhave\tO\nshown\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n,\tO\nstroke\tB-Disease\n,\tO\nhypertension\tB-Disease\nand\tO\nheart\tB-Disease\nfailure\tI-Disease\nduring\tO\ntreatment\tO\nwith\tO\ncyclooxygenase\tB-Chemical\ninhibitors\tI-Chemical\n.\tO\n\nAdverse\tO\ncardiovascular\tO\neffects\tO\noccurred\tO\nmainly\tO\n,\tO\nbut\tO\nnot\tO\nexclusively\tO\n,\tO\nin\tO\npatients\tO\nwith\tO\nconcomitant\tO\nrisk\tO\nfactors\tO\n.\tO\n\nCyclooxygenase\tB-Chemical\ninhibitors\tI-Chemical\ncause\tO\ncomplex\tO\nchanges\tO\nin\tO\nrenal\tO\n,\tO\nvascular\tO\nand\tO\ncardiac\tO\nprostanoid\tO\nprofiles\tO\nthereby\tO\nincreasing\tO\nvascular\tO\nresistance\tO\nand\tO\nfluid\tO\nretention\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ncardiovascular\tO\nadverse\tO\nevents\tO\ntends\tO\nto\tO\nincrease\tO\nwith\tO\nthe\tO\ndaily\tO\ndose\tO\nand\tO\ntotal\tO\nexposure\tO\ntime\tO\n.\tO\n\nA\tO\ncomparison\tO\nof\tO\nindividual\tO\nselective\tO\nand\tO\nunselective\tO\ncyclooxygenase\tB-Chemical\ninhibitors\tI-Chemical\nsuggests\tO\nsubstance\tO\n-\tO\nspecific\tO\ndifferences\tO\n,\tO\nwhich\tO\nmay\tO\ndepend\tO\non\tO\ndifferences\tO\nin\tO\npharmacokinetic\tO\nparameters\tO\nor\tO\ninhibitory\tO\npotency\tO\nand\tO\nmay\tO\nbe\tO\ncontributed\tO\nby\tO\nprostaglandin\tB-Chemical\n-\tO\nindependent\tO\neffects\tO\n.\tO\n\nDiagnostic\tO\nmarkers\tO\nsuch\tO\nas\tO\nN\tB-Chemical\n-\tI-Chemical\nterminal\tI-Chemical\npro\tI-Chemical\nbrain\tI-Chemical\nnatriuretic\tI-Chemical\npeptide\tI-Chemical\n(\tO\nNT\tB-Chemical\n-\tI-Chemical\nproBNP\tI-Chemical\n)\tO\nor\tO\nhigh\tO\n-\tO\nsensitive\tO\nC\tO\n-\tO\nreactive\tO\nprotein\tO\nmight\tO\nhelp\tO\nin\tO\nthe\tO\nearly\tO\nidentification\tO\nof\tO\npatients\tO\nat\tO\nrisk\tO\n,\tO\nthus\tO\navoiding\tO\nthe\tO\noccurrence\tO\nof\tO\nserious\tO\ncardiovascular\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nPilocarpine\tB-Chemical\nseizures\tB-Disease\ncause\tO\nage\tO\n-\tO\ndependent\tO\nimpairment\tB-Disease\nin\tI-Disease\nauditory\tI-Disease\nlocation\tI-Disease\ndiscrimination\tI-Disease\n.\tO\n\nChildren\tO\nwho\tO\nhave\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nhave\tO\ncontinuous\tO\nor\tO\nrapidly\tO\nrepeating\tO\nseizures\tB-Disease\nthat\tO\nmay\tO\nbe\tO\nlife\tO\n-\tO\nthreatening\tO\nand\tO\nmay\tO\ncause\tO\nlife\tO\n-\tO\nlong\tO\nchanges\tO\nin\tO\nbrain\tO\nand\tO\nbehavior\tO\n.\tO\n\nThe\tO\nextent\tO\nto\tO\nwhich\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\ncauses\tO\ndeficits\tB-Disease\nin\tI-Disease\nauditory\tI-Disease\ndiscrimination\tI-Disease\nis\tO\nunknown\tO\n.\tO\n\nA\tO\nnaturalistic\tO\nauditory\tO\nlocation\tO\ndiscrimination\tO\nmethod\tO\nwas\tO\nused\tO\nto\tO\nevaluate\tO\nthis\tO\nquestion\tO\nusing\tO\nan\tO\nanimal\tO\nmodel\tO\nof\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n.\tO\n\nMale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\ninjected\tO\nwith\tO\nsaline\tO\non\tO\npostnatal\tO\nday\tO\n(\tO\nP\tO\n)\tO\n20\tO\n,\tO\nor\tO\na\tO\nconvulsant\tO\ndose\tO\nof\tO\npilocarpine\tB-Chemical\non\tO\nP20\tO\nor\tO\nP45\tO\n.\tO\n\nPilocarpine\tB-Chemical\non\tO\neither\tO\nday\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n;\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nat\tO\nP45\tO\nresulted\tO\nin\tO\nCA3\tO\ncell\tO\nloss\tO\nand\tO\nspontaneous\tO\nseizures\tB-Disease\n,\tO\nwhereas\tO\nP20\tO\nrats\tO\nhad\tO\nno\tO\ncell\tO\nloss\tO\nor\tO\nspontaneous\tO\nseizures\tB-Disease\n.\tO\n\nMature\tO\nrats\tO\nwere\tO\ntrained\tO\nwith\tO\nsound\tO\n-\tO\nsource\tO\nlocation\tO\nand\tO\nsound\tO\n-\tO\nsilence\tO\ndiscriminations\tO\n.\tO\n\nControl\tO\n(\tO\nsaline\tO\nP20\tO\n)\tO\nrats\tO\nacquired\tO\nboth\tO\ndiscriminations\tO\nimmediately\tO\n.\tO\n\nIn\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n(\tO\nP20\tO\n)\tO\nrats\tO\n,\tO\nacquisition\tO\nof\tO\nthe\tO\nsound\tO\n-\tO\nsource\tO\nlocation\tO\ndiscrimination\tO\nwas\tO\nmoderately\tO\nimpaired\tO\n.\tO\n\nStatus\tB-Disease\nepilepticus\tI-Disease\n(\tO\nP45\tO\n)\tO\nrats\tO\nfailed\tO\nto\tO\nacquire\tO\neither\tO\nsound\tO\n-\tO\nsource\tO\nlocation\tO\nor\tO\nsound\tO\n-\tO\nsilence\tO\ndiscriminations\tO\n.\tO\n\nStatus\tB-Disease\nepilepticus\tI-Disease\nin\tO\nrat\tO\ncauses\tO\nan\tO\nage\tO\n-\tO\ndependent\tO\n,\tO\nlong\tO\n-\tO\nterm\tO\nimpairment\tB-Disease\nin\tI-Disease\nauditory\tI-Disease\ndiscrimination\tI-Disease\n.\tO\n\nThis\tO\nimpairment\tO\nmay\tO\nexplain\tO\none\tO\ncause\tO\nof\tO\nimpaired\tB-Disease\nauditory\tI-Disease\nlocation\tI-Disease\ndiscrimination\tI-Disease\nin\tO\nhumans\tO\n.\tO\n\nNerve\tO\ngrowth\tO\nfactor\tO\nand\tO\nprostaglandins\tB-Chemical\nin\tO\nthe\tO\nurine\tO\nof\tO\nfemale\tO\npatients\tO\nwith\tO\noveractive\tB-Disease\nbladder\tI-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nNGF\tO\nand\tO\nPGs\tB-Chemical\nin\tO\nthe\tO\nbladder\tO\ncan\tO\nbe\tO\naffected\tO\nby\tO\npathological\tO\nchanges\tO\nin\tO\nthe\tO\nbladder\tO\nand\tO\nthese\tO\nchanges\tO\ncan\tO\nbe\tO\ndetected\tO\nin\tO\nurine\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nchanges\tO\nin\tO\nurinary\tO\nNGF\tO\nand\tO\nPGs\tB-Chemical\nin\tO\nwomen\tO\nwith\tO\nOAB\tB-Disease\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nThe\tO\nstudy\tO\ngroups\tO\nincluded\tO\n65\tO\nwomen\tO\nwith\tO\nOAB\tB-Disease\nand\tO\n20\tO\nwithout\tO\nbladder\tO\nsymptoms\tO\nwho\tO\nserved\tO\nas\tO\ncontrols\tO\n.\tO\n\nEvaluation\tO\nincluded\tO\npatient\tO\nhistory\tO\n,\tO\nurinalysis\tO\n,\tO\na\tO\nvoiding\tO\ndiary\tO\nand\tO\nurodynamic\tO\nstudies\tO\n.\tO\n\nUrine\tO\nsamples\tO\nwere\tO\ncollected\tO\n.\tO\n\nNGF\tO\n,\tO\nPGE2\tB-Chemical\n,\tO\nPGF2alpha\tB-Chemical\nand\tO\nPGI2\tB-Chemical\nwere\tO\nmeasured\tO\nusing\tO\nenzyme\tO\n-\tO\nlinked\tO\nimmunosorbent\tO\nassay\tO\nand\tO\ncompared\tO\nbetween\tO\nthe\tO\ngroups\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\ncorrelations\tO\nbetween\tO\nurinary\tO\nNGF\tO\nand\tO\nPG\tB-Chemical\n,\tO\nand\tO\nurodynamic\tO\nparameters\tO\nin\tO\npatients\tO\nwith\tO\nOAB\tB-Disease\nwere\tO\nexamined\tO\n.\tO\n\nRESULTS\tO\n:\tO\nUrinary\tO\nNGF\tO\n,\tO\nPGE2\tB-Chemical\nand\tO\nPGF2alpha\tB-Chemical\nwere\tO\nsignificantly\tO\nincreased\tO\nin\tO\npatients\tO\nwith\tO\nOAB\tB-Disease\ncompared\tO\nwith\tO\ncontrols\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nurinary\tO\nPGI2\tB-Chemical\nwas\tO\nnot\tO\ndifferent\tO\nbetween\tO\ncontrols\tO\nand\tO\npatients\tO\nwith\tO\nOAB\tB-Disease\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\nOAB\tB-Disease\nurinary\tO\nPGE2\tB-Chemical\npositively\tO\ncorrelated\tO\nwith\tO\nvolume\tO\nat\tO\nfirst\tO\ndesire\tO\nto\tO\nvoid\tO\nand\tO\nmaximum\tO\ncystometric\tO\ncapacity\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nUrinary\tO\nNGF\tO\n,\tO\nPGF2alpha\tB-Chemical\nand\tO\nPGI2\tB-Chemical\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nurodynamic\tO\nparameters\tO\nin\tO\npatients\tO\nwith\tO\nOAB\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nNGF\tO\nand\tO\nPGs\tB-Chemical\nhave\tO\nimportant\tO\nroles\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nOAB\tB-Disease\nsymptoms\tO\nin\tO\nfemale\tO\npatients\tO\n.\tO\n\nUrinary\tO\nlevels\tO\nof\tO\nthese\tO\nfactors\tO\nmay\tO\nbe\tO\nused\tO\nas\tO\nmarkers\tO\nto\tO\nevaluate\tO\nOAB\tB-Disease\nsymptoms\tO\n.\tO\n\nDefinition\tO\nand\tO\nmanagement\tO\nof\tO\nanemia\tB-Disease\nin\tO\npatients\tO\ninfected\tB-Disease\nwith\tI-Disease\nhepatitis\tI-Disease\nC\tI-Disease\nvirus\tI-Disease\n.\tO\n\nChronic\tB-Disease\ninfection\tI-Disease\nwith\tI-Disease\nhepatitis\tI-Disease\nC\tI-Disease\nvirus\tI-Disease\n(\tO\nHCV\tO\n)\tO\ncan\tO\nprogress\tO\nto\tO\ncirrhosis\tB-Disease\n,\tO\nhepatocellular\tB-Disease\ncarcinoma\tI-Disease\n,\tO\nand\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nliver\tI-Disease\ndisease\tI-Disease\n.\tO\n\nThe\tO\ncurrent\tO\nbest\tO\ntreatment\tO\nfor\tO\nHCV\tB-Disease\ninfection\tI-Disease\nis\tO\ncombination\tO\ntherapy\tO\nwith\tO\npegylated\tO\ninterferon\tB-Chemical\nand\tO\nribavirin\tB-Chemical\n.\tO\n\nAlthough\tO\nthis\tO\nregimen\tO\nproduces\tO\nsustained\tO\nvirologic\tO\nresponses\tO\n(\tO\nSVRs\tO\n)\tO\nin\tO\napproximately\tO\n50\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nit\tO\ncan\tO\nbe\tO\nassociated\tO\nwith\tO\na\tO\npotentially\tO\ndose\tO\n-\tO\nlimiting\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nHemoglobin\tO\nconcentrations\tO\ndecrease\tO\nmainly\tO\nas\tO\na\tO\nresult\tO\nof\tO\nribavirin\tB-Chemical\n-\tO\ninduced\tO\nhemolysis\tB-Disease\n,\tO\nand\tO\nthis\tO\nanemia\tB-Disease\ncan\tO\nbe\tO\nproblematic\tO\nin\tO\npatients\tO\nwith\tO\nHCV\tB-Disease\ninfection\tI-Disease\n,\tO\nespecially\tO\nthose\tO\nwho\tO\nhave\tO\ncomorbid\tO\nrenal\tB-Disease\nor\tI-Disease\ncardiovascular\tI-Disease\ndisorders\tI-Disease\n.\tO\n\nIn\tO\ngeneral\tO\n,\tO\nanemia\tB-Disease\ncan\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nmorbidity\tO\nand\tO\nmortality\tO\n,\tO\nand\tO\nmay\tO\nhave\tO\nnegative\tO\neffects\tO\non\tO\ncerebral\tO\nfunction\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nAlthough\tO\nribavirin\tB-Chemical\n-\tO\nassociated\tO\nanemia\tB-Disease\ncan\tO\nbe\tO\nreversed\tO\nby\tO\ndose\tO\nreduction\tO\nor\tO\ndiscontinuation\tO\n,\tO\nthis\tO\napproach\tO\ncompromises\tO\noutcomes\tO\nby\tO\nsignificantly\tO\ndecreasing\tO\nSVR\tO\nrates\tO\n.\tO\n\nRecombinant\tO\nhuman\tO\nerythropoietin\tO\nhas\tO\nbeen\tO\nused\tO\nto\tO\nmanage\tO\nribavirin\tB-Chemical\n-\tO\nassociated\tO\nanemia\tB-Disease\nbut\tO\nhas\tO\nother\tO\npotential\tO\ndisadvantages\tO\n.\tO\n\nViramidine\tB-Chemical\n,\tO\na\tO\nliver\tO\n-\tO\ntargeting\tO\nprodrug\tO\nof\tO\nribavirin\tB-Chemical\n,\tO\nhas\tO\nthe\tO\npotential\tO\nto\tO\nmaintain\tO\nthe\tO\nvirologic\tO\nefficacy\tO\nof\tO\nribavirin\tB-Chemical\nwhile\tO\ndecreasing\tO\nthe\tO\nrisk\tO\nof\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nin\tO\npatients\tO\nwith\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nC\tI-Disease\n.\tO\n\nImpact\tO\nof\tO\nalcohol\tB-Chemical\nexposure\tO\nafter\tO\npregnancy\tO\nrecognition\tO\non\tO\nultrasonographic\tO\nfetal\tO\ngrowth\tO\nmeasures\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nMore\tO\nthan\tO\n3\tO\ndecades\tO\nafter\tO\nJones\tO\nand\tO\nSmith\tO\n(\tO\n1973\tO\n)\tO\nreported\tO\non\tO\nthe\tO\ndevastation\tO\ncaused\tO\nby\tO\nalcohol\tB-Chemical\nexposure\tO\non\tO\nfetal\tO\ndevelopment\tO\n,\tO\nthe\tO\nrates\tO\nof\tO\nheavy\tO\ndrinking\tO\nduring\tO\npregnancy\tO\nremain\tO\nrelatively\tO\nunchanged\tO\n.\tO\n\nEarly\tO\nidentification\tO\nof\tO\nfetal\tO\nalcohol\tB-Chemical\nexposure\tO\nand\tO\nmaternal\tO\nabstinence\tO\nled\tO\nto\tO\nbetter\tO\ninfant\tO\noutcomes\tO\n.\tO\n\nThis\tO\nstudy\tO\nexamined\tO\nthe\tO\nutility\tO\nof\tO\nbiometry\tO\nfor\tO\ndetecting\tO\nalcohol\tB-Chemical\n-\tO\nrelated\tO\nfetal\tO\ngrowth\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nobtained\tO\nfetal\tO\nultrasound\tO\nmeasures\tO\nfrom\tO\nroutine\tO\nultrasound\tO\nexaminations\tO\nfor\tO\n167\tO\npregnant\tO\nhazardous\tO\ndrinkers\tO\nwho\tO\nwere\tO\nenrolled\tO\nin\tO\na\tO\nbrief\tO\nalcohol\tB-Chemical\nintervention\tO\nstudy\tO\n.\tO\n\nThe\tO\nfetal\tO\nmeasures\tO\nfor\tO\nwomen\tO\nwho\tO\nquit\tO\nafter\tO\nlearning\tO\nof\tO\ntheir\tO\npregnancies\tO\nwere\tO\ncompared\tO\nwith\tO\nmeasures\tO\nfor\tO\nwomen\tO\nwho\tO\ncontinued\tO\nsome\tO\ndrinking\tO\nthroughout\tO\nthe\tO\ncourse\tO\nof\tO\ntheir\tO\npregnancies\tO\n.\tO\n\nBecause\tO\nintensity\tO\nof\tO\nalcohol\tB-Chemical\nconsumption\tO\nis\tO\nassociated\tO\nwith\tO\npoorer\tO\nfetal\tO\noutcomes\tO\n,\tO\nseparate\tO\nanalyses\tO\nwere\tO\nconducted\tO\nfor\tO\nthe\tO\nheavy\tO\n(\tO\naverage\tO\nof\tO\n>\tO\nor\tO\n=\tO\n5\tO\ndrinks\tO\nper\tO\ndrinking\tO\nday\tO\n)\tO\nalcohol\tB-Chemical\nconsumers\tO\n.\tO\n\nFetal\tO\nmeasures\tO\nfrom\tO\nthe\tO\nheavy\tO\n-\tO\nexposed\tO\nfetuses\tO\nwere\tO\nalso\tO\ncompared\tO\nwith\tO\nmeasures\tO\nfrom\tO\na\tO\nnondrinking\tO\ngroup\tO\nthat\tO\nwas\tO\nrepresentative\tO\nof\tO\nnormal\tO\n,\tO\nuncomplicated\tO\npregnancies\tO\nfrom\tO\nour\tO\nclinics\tO\n.\tO\n\nAnalyses\tO\nof\tO\ncovariance\tO\nwere\tO\nused\tO\nto\tO\ndetermine\tO\nwhether\tO\nthere\tO\nwere\tO\ndifferences\tO\nbetween\tO\ngroups\tO\nafter\tO\ncontrolling\tO\nfor\tO\ninfluences\tO\nof\tO\ngestational\tO\nage\tO\nand\tO\ndrug\tB-Disease\nabuse\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nNearly\tO\nhalf\tO\nof\tO\nthe\tO\npregnant\tO\ndrinkers\tO\nabstained\tO\nafter\tO\nlearning\tO\nof\tO\ntheir\tO\npregnancies\tO\n.\tO\n\nWhen\tO\nwomen\tO\nreportedly\tO\nquit\tO\ndrinking\tO\nearly\tO\nin\tO\ntheir\tO\npregnancies\tO\n,\tO\nfetal\tO\ngrowth\tO\nmeasures\tO\nwere\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\nfrom\tO\na\tO\nnon\tO\n-\tO\nalcohol\tB-Chemical\n-\tO\nexposed\tO\ngroup\tO\n,\tO\nregardless\tO\nof\tO\nprior\tO\ndrinking\tO\npatterns\tO\n.\tO\n\nAny\tO\nalcohol\tB-Chemical\nconsumption\tO\npostpregnancy\tO\nrecognition\tO\namong\tO\nthe\tO\nheavy\tO\ndrinkers\tO\nresulted\tO\nin\tO\nreduced\tB-Disease\ncerebellar\tI-Disease\ngrowth\tI-Disease\nas\tO\nwell\tO\nas\tO\ndecreased\tB-Disease\ncranial\tI-Disease\nto\tI-Disease\nbody\tI-Disease\ngrowth\tI-Disease\nin\tO\ncomparison\tO\nwith\tO\nwomen\tO\nwho\tO\neither\tO\nquit\tO\ndrinking\tO\nor\tO\nwho\tO\nwere\tO\nnondrinkers\tO\n.\tO\n\nAmphetamine\tB-Chemical\nabuse\tO\nwas\tO\npredictive\tO\nof\tO\nlarger\tO\ncranial\tO\nto\tO\nbody\tO\ngrowth\tO\nratios\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAlterations\tO\nin\tO\nfetal\tO\nbiometric\tO\nmeasurements\tO\nwere\tO\nobserved\tO\namong\tO\nthe\tO\nheavy\tO\ndrinkers\tO\nonly\tO\nwhen\tO\nthey\tO\ncontinued\tO\ndrinking\tO\nafter\tO\nbecoming\tO\naware\tO\nof\tO\ntheir\tO\npregnancies\tO\n.\tO\n\nAlthough\tO\nthe\tO\nreliance\tO\non\tO\nself\tO\n-\tO\nreported\tO\ndrinking\tO\nis\tO\na\tO\nlimitation\tO\nin\tO\nthis\tO\nstudy\tO\n,\tO\nthese\tO\nfindings\tO\nsupport\tO\nthe\tO\nbenefits\tO\nof\tO\nearly\tO\nabstinence\tO\nand\tO\nthe\tO\npotential\tO\nfor\tO\nultrasound\tO\nexaminations\tO\nin\tO\nthe\tO\ndetection\tO\nof\tO\nfetal\tO\nalcohol\tB-Chemical\neffects\tO\n.\tO\n\nEthambutol\tB-Chemical\n-\tO\nassociated\tO\noptic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nINTRODUCTION\tO\n:\tO\nEthambutol\tB-Chemical\nis\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\ntuberculosis\tB-Disease\n,\tO\nwhich\tO\nis\tO\nstill\tO\nprevalent\tO\nin\tO\nSoutheast\tO\nAsia\tO\n,\tO\nand\tO\ncan\tO\nbe\tO\nassociated\tO\nwith\tO\npermanent\tO\nvisual\tB-Disease\nloss\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\n3\tO\ncases\tO\nwhich\tO\npresented\tO\nwith\tO\nbitemporal\tB-Disease\nhemianopia\tI-Disease\n.\tO\n\nCLINICAL\tO\nPICTURE\tO\n:\tO\nThree\tO\npatients\tO\nwith\tO\nethambutol\tB-Chemical\n-\tO\nassociated\tO\ntoxic\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nare\tO\ndescribed\tO\n.\tO\n\nAll\tO\n3\tO\npatients\tO\nhad\tO\nloss\tB-Disease\nof\tI-Disease\ncentral\tI-Disease\nvisual\tI-Disease\nacuity\tI-Disease\n,\tI-Disease\ncolour\tI-Disease\nvision\tI-Disease\n(\tI-Disease\nIshihara\tI-Disease\n)\tI-Disease\nand\tI-Disease\nvisual\tI-Disease\nfield\tI-Disease\n.\tO\n\nThe\tO\nvisual\tB-Disease\nfield\tI-Disease\nloss\tI-Disease\nhad\tO\na\tO\nbitemporal\tO\nflavour\tO\n,\tO\nsuggesting\tO\ninvolvement\tO\nof\tO\nthe\tO\noptic\tO\nchiasm\tO\n.\tO\n\nTREATMENT\tO\n:\tO\nDespite\tO\nstopping\tO\nethambutol\tB-Chemical\non\tO\ndiagnosis\tO\n,\tO\nvisual\tO\nfunction\tO\ncontinued\tO\nto\tO\ndeteriorate\tO\nfor\tO\na\tO\nfew\tO\nmonths\tO\n.\tO\n\nSubsequent\tO\nimprovement\tO\nwas\tO\nmild\tO\nin\tO\n2\tO\ncases\tO\n.\tO\n\nIn\tO\nthe\tO\nthird\tO\ncase\tO\n,\tO\nvisual\tO\nacuity\tO\nand\tO\ncolour\tO\nvision\tO\nnormalised\tO\nbut\tO\nthe\tO\noptic\tO\ndiscs\tO\nwere\tO\npale\tO\n.\tO\n\nOUTCOME\tO\n:\tO\nAll\tO\n3\tO\npatients\tO\nhad\tO\nsome\tO\npermanent\tO\nloss\tB-Disease\nof\tI-Disease\nvisual\tI-Disease\nfunction\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nEthambutol\tB-Chemical\nusage\tO\nis\tO\nassociated\tO\nwith\tO\npermanent\tO\nvisual\tB-Disease\nloss\tI-Disease\nand\tO\nshould\tO\nbe\tO\navoided\tO\nif\tO\npossible\tO\nor\tO\nused\tO\nwith\tO\ncaution\tO\nand\tO\nproper\tO\nophthalmological\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nThe\tO\nauthor\tO\npostulates\tO\nthat\tO\nin\tO\ncases\tO\nof\tO\nethambutol\tB-Chemical\nassociated\tO\nchiasmopathy\tO\n,\tO\nethambutol\tB-Chemical\nmay\tO\ninitially\tO\naffect\tO\nthe\tO\noptic\tO\nnerves\tO\nand\tO\nsubsequently\tO\nprogress\tO\nto\tO\ninvolve\tO\nthe\tO\noptic\tO\nchiasm\tO\n.\tO\n\nPossible\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nrelated\tO\nto\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\nparoxetine\tB-Chemical\nand\tO\nalprazolam\tB-Chemical\n.\tO\n\nA\tO\n74\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\ndepressive\tB-Disease\nsymptoms\tI-Disease\nwas\tO\nadmitted\tO\nto\tO\na\tO\npsychiatric\tB-Disease\nhospital\tO\ndue\tO\nto\tO\ninsomnia\tB-Disease\n,\tO\nloss\tB-Disease\nof\tI-Disease\nappetite\tI-Disease\n,\tO\nexhaustion\tO\n,\tO\nand\tO\nagitation\tB-Disease\n.\tO\n\nMedical\tO\ntreatment\tO\nwas\tO\ninitiated\tO\nat\tO\na\tO\ndaily\tO\ndose\tO\nof\tO\n20\tO\nmg\tO\nparoxetine\tB-Chemical\nand\tO\n1\tO\n.\tO\n2\tO\nmg\tO\nalprazolam\tB-Chemical\n.\tO\n\nOn\tO\nthe\tO\n10th\tO\nday\tO\nof\tO\nparoxetine\tB-Chemical\nand\tO\nalprazolam\tB-Chemical\ntreatment\tO\n,\tO\nthe\tO\npatient\tO\nexhibited\tO\nmarked\tO\npsychomotor\tB-Disease\nretardation\tI-Disease\n,\tO\ndisorientation\tO\n,\tO\nand\tO\nsevere\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\nwith\tO\ntremors\tB-Disease\n.\tO\n\nThe\tO\npatient\tO\nhad\tO\na\tO\nfever\tB-Disease\n(\tO\n38\tO\n.\tO\n2\tO\ndegrees\tO\nC\tO\n)\tO\n,\tO\nfluctuating\tO\nblood\tO\npressure\tO\n(\tO\nbetween\tO\n165\tO\n/\tO\n90\tO\nand\tO\n130\tO\n/\tO\n70\tO\nmg\tO\nmm\tO\nHg\tO\n)\tO\n,\tO\nand\tO\nsevere\tO\nextrapyramidal\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nLaboratory\tO\ntests\tO\nshowed\tO\nan\tO\nelevation\tO\nof\tO\ncreatine\tB-Chemical\nphosphokinase\tO\n(\tO\n2218\tO\nIU\tO\n/\tO\nL\tO\n)\tO\n,\tO\naspartate\tB-Chemical\naminotransferase\tO\n(\tO\n134\tO\nIU\tO\n/\tO\nL\tO\n)\tO\n,\tO\nalanine\tB-Chemical\naminotransferase\tO\n(\tO\n78\tO\nIU\tO\n/\tO\nL\tO\n)\tO\n,\tO\nand\tO\nBUN\tO\n(\tO\n27\tO\n.\tO\n9\tO\nmg\tO\n/\tO\nml\tO\n)\tO\nlevels\tO\n.\tO\n\nThe\tO\npatient\tO\nreceived\tO\nbromocriptine\tB-Chemical\nand\tO\ndiazepam\tB-Chemical\nto\tO\ntreat\tO\nhis\tO\nsymptoms\tO\n.\tO\n\n7\tO\ndays\tO\nlater\tO\n,\tO\nthe\tO\nfever\tB-Disease\ndisappeared\tO\nand\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nserum\tO\nCPK\tO\nlevels\tO\nwere\tO\nnormalized\tO\n(\tO\n175\tO\nIU\tO\n/\tO\nL\tO\n)\tO\n.\tO\n\nThis\tO\npatient\tO\npresented\tO\nwith\tO\nsymptoms\tO\nof\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\n(\tO\nNMS\tB-Disease\n)\tO\n,\tO\nthus\tO\ndemonstrating\tO\nthat\tO\nNMS\tB-Disease\n-\tO\nlike\tO\nsymptoms\tO\ncan\tO\noccur\tO\nafter\tO\ncombined\tO\nparoxetine\tB-Chemical\nand\tO\nalprazolam\tB-Chemical\ntreatment\tO\n.\tO\n\nThe\tO\nadverse\tO\ndrug\tO\nreaction\tO\nscore\tO\nobtained\tO\nby\tO\nthe\tO\nNaranjo\tO\nalgorithm\tO\nwas\tO\n6\tO\nin\tO\nour\tO\ncase\tO\n,\tO\nindicating\tO\na\tO\nprobable\tO\nrelationship\tO\nbetween\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nNMS\tB-Disease\n-\tO\nlike\tO\nadverse\tO\nsymptoms\tO\nand\tO\nthe\tO\ncombined\tO\ntreatment\tO\nused\tO\nin\tO\nthis\tO\ncase\tO\n.\tO\n\nThe\tO\ninvolvement\tO\nof\tO\nphysiologic\tO\nand\tO\nenvironmental\tO\naspects\tO\nspecific\tO\nto\tO\nthis\tO\npatient\tO\nwas\tO\nsuspected\tO\n.\tO\n\nSeveral\tO\nrisk\tO\nfactors\tO\nfor\tO\nNMS\tB-Disease\nshould\tO\nbe\tO\nnoted\tO\nin\tO\nelderly\tO\ndepressive\tB-Disease\npatients\tO\nwhose\tO\nsymptoms\tO\noften\tO\ninclude\tO\ndehydration\tB-Disease\n,\tO\nagitation\tB-Disease\n,\tO\nmalnutrition\tB-Disease\n,\tO\nand\tO\nexhaustion\tO\n.\tO\n\nCareful\tO\ntherapeutic\tO\nintervention\tO\nis\tO\nnecessary\tO\nin\tO\ncases\tO\ninvolving\tO\nelderly\tO\npatients\tO\nwho\tO\nsuffer\tO\nfrom\tO\ndepression\tB-Disease\n.\tO\n\nDown\tO\n-\tO\nregulation\tO\nof\tO\nnorepinephrine\tB-Chemical\ntransporter\tO\nfunction\tO\ninduced\tO\nby\tO\nchronic\tO\nadministration\tO\nof\tO\ndesipramine\tB-Chemical\nlinking\tO\nto\tO\nthe\tO\nalteration\tO\nof\tO\nsensitivity\tO\nof\tO\nlocal\tO\n-\tO\nanesthetics\tO\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nand\tO\nthe\tO\ncounteraction\tO\nby\tO\nco\tO\n-\tO\nadministration\tO\nwith\tO\nlocal\tO\nanesthetics\tO\n.\tO\n\nAlterations\tO\nof\tO\nnorepinephrine\tB-Chemical\ntransporter\tO\n(\tO\nNET\tO\n)\tO\nfunction\tO\nby\tO\nchronic\tO\ninhibition\tO\nof\tO\nNET\tO\nin\tO\nrelation\tO\nto\tO\nsensitization\tO\nto\tO\nseizures\tB-Disease\ninduce\tO\nby\tO\ncocaine\tB-Chemical\nand\tO\nlocal\tO\nanesthetics\tO\nwere\tO\nstudied\tO\nin\tO\nmice\tO\n.\tO\n\nDaily\tO\nadministration\tO\nof\tO\ndesipramine\tB-Chemical\n,\tO\nan\tO\ninhibitor\tO\nof\tO\nthe\tO\nNET\tO\n,\tO\nfor\tO\n5\tO\ndays\tO\ndecreased\tO\n[\tO\n(\tO\n3\tO\n)\tO\nH\tO\n]\tO\nnorepinephrine\tB-Chemical\nuptake\tO\nin\tO\nthe\tO\nP2\tO\nfractions\tO\nof\tO\nhippocampus\tO\nbut\tO\nnot\tO\ncortex\tO\n,\tO\nstriatum\tO\nor\tO\namygdalae\tO\n.\tO\n\nCo\tO\n-\tO\nadministration\tO\nof\tO\nlidocaine\tB-Chemical\n,\tO\nbupivacaine\tB-Chemical\nor\tO\ntricaine\tB-Chemical\nwith\tO\ndesipramine\tB-Chemical\nreversed\tO\nthis\tO\neffect\tO\n.\tO\n\nDaily\tO\ntreatment\tO\nof\tO\ncocaine\tB-Chemical\nincreased\tO\n[\tO\n(\tO\n3\tO\n)\tO\nH\tO\n]\tO\nnorepinephrine\tB-Chemical\nuptake\tO\ninto\tO\nthe\tO\nhippocampus\tO\n.\tO\n\nDaily\tO\nadministration\tO\nof\tO\ndesipramine\tB-Chemical\nincreased\tO\nthe\tO\nincidence\tO\nof\tO\nappearance\tO\nof\tO\nlidocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nCo\tO\n-\tO\nadministration\tO\nof\tO\nlidocaine\tB-Chemical\nwith\tO\ndesipramine\tB-Chemical\nreversed\tO\nthe\tO\nchanges\tO\nof\tO\nconvulsive\tB-Disease\nactivity\tO\nof\tO\nlidocaine\tB-Chemical\nand\tO\ncocaine\tB-Chemical\ninduced\tO\nby\tO\nrepeated\tO\nadministration\tO\nof\tO\ndesipramine\tB-Chemical\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\ndown\tO\n-\tO\nregulation\tO\nof\tO\nhippocampal\tO\nNET\tO\ninduced\tO\nby\tO\nchronic\tO\nadministration\tO\nof\tO\ndesipramine\tB-Chemical\nmay\tO\nbe\tO\nrelevant\tO\nto\tO\ndesipramine\tB-Chemical\n-\tO\ninduced\tO\nsensitization\tO\nof\tO\nlidocaine\tB-Chemical\nconvulsions\tB-Disease\n.\tO\n\nInhibition\tO\nof\tO\nNa\tB-Chemical\n(\tO\n+\tO\n)\tO\nchannels\tO\nby\tO\nlocal\tO\nanesthetics\tO\nmay\tO\nregulate\tO\ndesipramine\tB-Chemical\n-\tO\ninduced\tO\ndown\tO\n-\tO\nregulation\tO\nof\tO\nNET\tO\nfunction\tO\n.\tO\n\nRepeated\tO\nadministration\tO\nof\tO\ncocaine\tB-Chemical\ninduces\tO\nup\tO\n-\tO\nregulation\tO\nof\tO\nhippocampal\tO\nNET\tO\nfunction\tO\n.\tO\n\nDesipramine\tB-Chemical\n-\tO\ninduced\tO\nsensitization\tO\nof\tO\nlidocaine\tB-Chemical\nseizures\tB-Disease\nmay\tO\nhave\tO\na\tO\nmechanism\tO\ndistinct\tO\nfrom\tO\nkindling\tO\nresulting\tO\nfrom\tO\nrepeated\tO\nadministration\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nAtorvastatin\tB-Chemical\nprevented\tO\nand\tO\nreversed\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nantioxidant\tO\neffects\tO\nof\tO\natorvastatin\tB-Chemical\n(\tO\natorva\tB-Chemical\n)\tO\non\tO\ndexamethasone\tB-Chemical\n(\tO\ndex\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nhypertension\tB-Disease\n,\tO\n60\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\ntreated\tO\nwith\tO\natorva\tB-Chemical\n30\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nor\tO\ntap\tO\nwater\tO\nfor\tO\n15\tO\ndays\tO\n.\tO\n\nDex\tB-Chemical\nincreased\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\nSBP\tO\n)\tO\nfrom\tO\n109\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n8\tO\nto\tO\n135\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n6\tO\nmmHg\tO\nand\tO\nplasma\tO\nsuperoxide\tB-Chemical\n(\tO\n5711\tO\n+\tO\n/\tO\n-\tO\n284\tO\n.\tO\n9\tO\nsaline\tO\n,\tO\n7931\tO\n+\tO\n/\tO\n-\tO\n392\tO\n.\tO\n8\tO\nU\tO\n/\tO\nml\tO\ndex\tB-Chemical\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nIn\tO\nthis\tO\nprevention\tO\nstudy\tO\n,\tO\nSBP\tO\nin\tO\nthe\tO\natorva\tB-Chemical\n+\tO\ndex\tB-Chemical\ngroup\tO\nwas\tO\nincreased\tO\nfrom\tO\n115\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n4\tO\nto\tO\n124\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n5\tO\nmmHg\tO\n,\tO\nbut\tO\nthis\tO\nwas\tO\nsignificantly\tO\nlower\tO\nthan\tO\nin\tO\nthe\tO\ndex\tB-Chemical\n-\tO\nonly\tO\ngroup\tO\n(\tO\nP\tO\n'\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nAtorva\tB-Chemical\nreversed\tO\ndex\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n(\tO\n129\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n6\tO\nmmHg\tO\n,\tO\nvs\tO\n.\tO\n135\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n6\tO\nmmHg\tO\nP\tO\n'\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\ndecreased\tO\nplasma\tO\nsuperoxide\tB-Chemical\n(\tO\n7931\tO\n+\tO\n/\tO\n-\tO\n392\tO\n.\tO\n8\tO\ndex\tB-Chemical\n,\tO\n1187\tO\n+\tO\n/\tO\n-\tO\n441\tO\n.\tO\n2\tO\natorva\tB-Chemical\n+\tO\ndex\tB-Chemical\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nPlasma\tO\nnitrate\tB-Chemical\n/\tO\nnitrite\tB-Chemical\n(\tO\nNOx\tO\n)\tO\nwas\tO\ndecreased\tO\nin\tO\ndex\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\ncompared\tO\nto\tO\nsaline\tO\n-\tO\ntreated\tO\nrats\tO\n(\tO\n11\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n08\tO\nmicrom\tO\n,\tO\n15\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n17\tO\nmicrom\tO\n,\tO\nrespectively\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nAtorva\tB-Chemical\naffected\tO\nneither\tO\nplasma\tO\nNOx\tO\nnor\tO\nthymus\tO\nweight\tO\n.\tO\n\nThus\tO\n,\tO\natorvastatin\tB-Chemical\nprevented\tO\nand\tO\nreversed\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nPeripheral\tB-Disease\nneuropathy\tI-Disease\ncaused\tO\nby\tO\nhigh\tO\n-\tO\ndose\tO\ncytosine\tB-Chemical\narabinoside\tI-Chemical\ntreatment\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nacute\tB-Disease\nmyeloid\tI-Disease\nleukemia\tI-Disease\n.\tO\n\nThe\tO\ncentral\tO\nnervous\tO\nsystem\tO\ntoxicity\tB-Disease\nof\tO\nhigh\tO\n-\tO\ndose\tO\ncytosine\tB-Chemical\narabinoside\tI-Chemical\nis\tO\nwell\tO\nrecognized\tO\n,\tO\nbut\tO\nthe\tO\ntoxicity\tB-Disease\nof\tO\ncytosine\tB-Chemical\narabinoside\tI-Chemical\nin\tO\nthe\tO\nperipheral\tO\nnervous\tO\nsystem\tO\nhas\tO\nbeen\tO\ninfrequently\tO\nreported\tO\n.\tO\n\nA\tO\n49\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nJapanese\tO\nman\tO\nwas\tO\ndiagnosed\tO\nwith\tO\nacute\tB-Disease\nmyeloid\tI-Disease\nleukemia\tI-Disease\n.\tO\n\nAfter\tO\nhe\tO\nachieved\tO\ncomplete\tO\nremission\tO\n,\tO\nhe\tO\nreceived\tO\nhigh\tO\n-\tO\ndose\tO\ncytosine\tB-Chemical\narabinoside\tI-Chemical\ntreatment\tO\n(\tO\n2\tO\ng\tO\n/\tO\nm2\tO\ntwice\tO\na\tO\nday\tO\nfor\tO\n5\tO\ndays\tO\n;\tO\ntotal\tO\n,\tO\n20\tO\ng\tO\n/\tO\nm2\tO\n)\tO\nas\tO\nconsolidation\tO\ntherapy\tO\n.\tO\n\nThe\tO\nfirst\tO\ncourse\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\ncytosine\tB-Chemical\narabinoside\tI-Chemical\nresulted\tO\nin\tO\nno\tO\nunusual\tO\nsymptoms\tO\n,\tO\nbut\tO\non\tO\nday\tO\n21\tO\nof\tO\nthe\tO\nsecond\tO\ncourse\tO\nof\tO\ntreatment\tO\n,\tO\nthe\tO\npatient\tO\ncomplained\tO\nof\tO\nnumbness\tB-Disease\nin\tO\nhis\tO\nright\tO\nfoot\tO\n.\tO\n\nElectromyogram\tO\nand\tO\nnerve\tO\n-\tO\nconduction\tO\nstudies\tO\nshowed\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\nin\tO\nboth\tO\nperoneal\tO\nnerves\tO\n.\tO\n\nThis\tO\nneuropathy\tB-Disease\nwas\tO\ngradually\tO\nresolving\tO\n;\tO\nhowever\tO\n,\tO\nafter\tO\nthe\tO\npatient\tO\nreceived\tO\nallogeneic\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\n,\tO\nthe\tO\nsymptoms\tO\nworsened\tO\n,\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\ngraft\tB-Disease\n-\tI-Disease\nversus\tI-Disease\n-\tI-Disease\nhost\tI-Disease\ndisease\tI-Disease\n,\tO\nand\tO\nthe\tO\nsymptoms\tO\nsubsequently\tO\nresponded\tO\nto\tO\nmethylprednisolone\tB-Chemical\n.\tO\n\nAlthough\tO\nthe\tO\nmechanisms\tO\nof\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\nare\tO\nstill\tO\nunclear\tO\n,\tO\nhigh\tO\n-\tO\ndose\tO\ncytosine\tB-Chemical\narabinoside\tI-Chemical\nis\tO\na\tO\ntherapy\tO\nthat\tO\nis\tO\npotentially\tO\ntoxic\tO\nto\tO\nthe\tO\nperipheral\tO\nnervous\tO\nsystem\tO\n,\tO\nand\tO\nauto\tO\n/\tO\nalloimmunity\tO\nmay\tO\nplay\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthese\tO\nmechanisms\tO\n.\tO\n\nEffect\tO\nof\tO\nalpha\tB-Chemical\n-\tI-Chemical\ntocopherol\tI-Chemical\nand\tO\ndeferoxamine\tB-Chemical\non\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\n.\tO\n\nMethamphetamine\tB-Chemical\n(\tO\nMA\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ndopaminergic\tO\nneurotoxicity\tB-Disease\nis\tO\nbelieved\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nincreased\tO\nformation\tO\nof\tO\nfree\tO\nradicals\tO\n.\tO\n\nThis\tO\nstudy\tO\nexamined\tO\nthe\tO\neffect\tO\nof\tO\nalpha\tB-Chemical\n-\tI-Chemical\ntocopherol\tI-Chemical\n(\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTC\tI-Chemical\n)\tO\n,\tO\na\tO\nscavenger\tO\nof\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\n,\tO\nand\tO\ndeferoxamine\tB-Chemical\n(\tO\nDFO\tB-Chemical\n)\tO\n,\tO\nan\tO\niron\tB-Chemical\nchelator\tO\n,\tO\non\tO\nthe\tO\nMA\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\n.\tO\n\nMale\tO\nrats\tO\nwere\tO\ntreated\tO\nwith\tO\nMA\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nevery\tO\n2\tO\nh\tO\nfor\tO\nfour\tO\ninjections\tO\n)\tO\n.\tO\n\nThe\tO\nrat\tO\nreceived\tO\neither\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTC\tI-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nintraperitoneally\tO\nfor\tO\n3\tO\ndays\tO\nand\tO\n30\tO\nmin\tO\nprior\tO\nto\tO\nMA\tB-Chemical\nadministration\tO\nor\tO\nDFO\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nsubcutaneously\tO\n30\tO\nmin\tO\nbefore\tO\nMA\tB-Chemical\nadministration\tO\n.\tO\n\nThe\tO\nconcentrations\tO\nof\tO\ndopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\n,\tO\nserotonin\tB-Chemical\nand\tO\ntheir\tO\nmetabolites\tO\ndecreased\tO\nsignificantly\tO\nafter\tO\nMA\tB-Chemical\nadministration\tO\n,\tO\nwhich\tO\nwas\tO\ninhibited\tO\nby\tO\nthe\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTC\tI-Chemical\nand\tO\nDFO\tB-Chemical\npretreatment\tO\n.\tO\n\nalpha\tB-Chemical\n-\tI-Chemical\nTC\tI-Chemical\nand\tO\nDFO\tB-Chemical\nattenuated\tO\nthe\tO\nMA\tB-Chemical\n-\tO\ninduced\tO\nhyperthermia\tB-Disease\nas\tO\nwell\tO\nas\tO\nthe\tO\nalterations\tO\nin\tO\nthe\tO\nlocomotor\tO\nactivity\tO\n.\tO\n\nThe\tO\nlevel\tO\nof\tO\nlipid\tO\nperoxidation\tO\nwas\tO\nhigher\tO\nand\tO\nthe\tO\nreduced\tO\nglutathione\tB-Chemical\nconcentration\tO\nwas\tO\nlower\tO\nin\tO\nthe\tO\nMA\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nThese\tO\nchanges\tO\nwere\tO\nsignificantly\tO\nattenuated\tO\nby\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTC\tI-Chemical\nand\tO\nDFO\tB-Chemical\n.\tO\n\nThis\tO\nsuggests\tO\nthat\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTC\tI-Chemical\nand\tO\nDFO\tB-Chemical\nameliorate\tO\nthe\tO\nMA\tB-Chemical\n-\tO\ninduced\tO\nneuronal\tB-Disease\ndamage\tI-Disease\nby\tO\ndecreasing\tO\nthe\tO\nlevel\tO\nof\tO\noxidative\tO\nstress\tO\n.\tO\n\nBlockade\tO\nof\tO\nboth\tO\nD\tO\n-\tO\n1\tO\nand\tO\nD\tO\n-\tO\n2\tO\ndopamine\tB-Chemical\nreceptors\tO\nmay\tO\ninduce\tO\ncatalepsy\tB-Disease\nin\tO\nmice\tO\n.\tO\n\n1\tO\n.\tO\n\nThe\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\ndopamine\tB-Chemical\nantagonists\tO\nhas\tO\nbeen\tO\ntested\tO\nand\tO\nthe\tO\npossible\tO\ndopamine\tB-Chemical\nsubtypes\tO\ninvolved\tO\nin\tO\ncatalepsy\tB-Disease\nwas\tO\ndetermined\tO\n.\tO\n\n2\tO\n.\tO\n\nDopamine\tB-Chemical\nantagonist\tO\nfluphenazine\tB-Chemical\n,\tO\nD\tO\n-\tO\n1\tO\nantagonist\tO\nSCH\tB-Chemical\n23390\tI-Chemical\nor\tO\nD\tO\n-\tO\n2\tO\nantagonist\tO\nsulpiride\tB-Chemical\ninduced\tO\ncatalepsy\tB-Disease\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nfluphenazine\tB-Chemical\nand\tO\nsulpiride\tB-Chemical\nwas\tO\ndose\tO\n-\tO\ndependent\tO\n.\tO\n\nCombination\tO\nof\tO\nSCH\tB-Chemical\n23390\tI-Chemical\nwith\tO\nsulpiride\tB-Chemical\ndid\tO\nnot\tO\ninduce\tO\ncatalepsy\tB-Disease\npotentiation\tO\n.\tO\n\n3\tO\n.\tO\n\nD\tO\n-\tO\n1\tO\nagonist\tO\nSKF\tB-Chemical\n38393\tI-Chemical\nor\tO\nD\tO\n-\tO\n2\tO\nagonist\tO\nquinpirole\tB-Chemical\ndecreased\tO\nthe\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nfluphenazine\tB-Chemical\n,\tO\nSCH\tB-Chemical\n23390\tI-Chemical\nor\tO\nsulpiride\tB-Chemical\n.\tO\n\n4\tO\n.\tO\n\nCombination\tO\nof\tO\nSKF\tB-Chemical\n38393\tI-Chemical\nwith\tO\nquinpirole\tB-Chemical\ndid\tO\nnot\tO\ncause\tO\npotentiated\tO\ninhibitory\tO\neffect\tO\non\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\ndopamine\tB-Chemical\nantagonists\tO\n.\tO\n\n5\tO\n.\tO\n\nThe\tO\ndata\tO\nmay\tO\nindicate\tO\nthat\tO\nalthough\tO\nD\tO\n-\tO\n2\tO\nreceptor\tO\nblockade\tO\nis\tO\ninvolved\tO\nin\tO\ncatalepsy\tB-Disease\n,\tO\nthe\tO\nD\tO\n-\tO\n1\tO\nreceptor\tO\nmay\tO\nplan\tO\na\tO\nrole\tO\n.\tO\n\nSustained\tO\nclinical\tO\nimprovement\tO\nof\tO\na\tO\npatient\tO\nwith\tO\ndecompensated\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\n-\tO\nrelated\tO\ncirrhosis\tB-Disease\nafter\tO\ntreatment\tO\nwith\tO\nlamivudine\tB-Chemical\nmonotherapy\tO\n.\tO\n\nHepatitis\tB-Disease\nB\tI-Disease\nvirus\tI-Disease\n(\tI-Disease\nHBV\tI-Disease\n)\tI-Disease\ninfection\tI-Disease\n,\tO\nwhich\tO\ncauses\tO\nliver\tB-Disease\ncirrhosis\tI-Disease\nand\tO\nhepatocellular\tB-Disease\ncarcinoma\tI-Disease\n,\tO\nremains\tO\na\tO\nmajor\tO\nhealth\tO\nproblem\tO\nin\tO\nAsian\tO\ncountries\tO\n.\tO\n\nRecent\tO\ndevelopment\tO\nof\tO\nvaccine\tO\nfor\tO\nprevention\tO\nis\tO\nreported\tO\nto\tO\nbe\tO\nsuccessful\tO\nin\tO\nreducing\tO\nthe\tO\nsize\tO\nof\tO\nchronically\tO\ninfected\tO\ncarriers\tO\n,\tO\nalthough\tO\nthe\tO\nstandard\tO\nmedical\tO\ntherapies\tO\nhave\tO\nnot\tO\nbeen\tO\nestablished\tO\nup\tO\nto\tO\nnow\tO\n.\tO\n\nIn\tO\nthis\tO\nreport\tO\n,\tO\nwe\tO\nencountered\tO\na\tO\npatient\tO\nwith\tO\ndecompensated\tO\nHBV\tO\n-\tO\nrelated\tO\ncirrhosis\tB-Disease\nwho\tO\nexhibited\tO\nthe\tO\ndramatic\tO\nimprovements\tO\nafter\tO\nantiviral\tO\ntherapy\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\na\tO\n50\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\n.\tO\n\nPrevious\tO\nconventional\tO\nmedical\tO\ntreatments\tO\nwere\tO\nnot\tO\neffective\tO\nfor\tO\nthis\tO\npatient\tO\n,\tO\nthus\tO\nthis\tO\npatient\tO\nhad\tO\nbeen\tO\nreferred\tO\nto\tO\nour\tO\nhospital\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nadministration\tO\nof\tO\nlamivudine\tB-Chemical\n,\tO\na\tO\nreverse\tO\ntranscriptase\tO\ninhibitor\tO\n,\tO\nfor\tO\n23\tO\nmonths\tO\ndramatically\tO\nimproved\tO\nher\tO\nliver\tO\nseverity\tO\n.\tO\n\nDuring\tO\nthis\tO\nperiod\tO\n,\tO\nno\tO\ndrug\tO\nresistant\tO\nmutant\tO\nHBV\tO\nemerged\tO\n,\tO\nand\tO\nthe\tO\nserum\tO\nHBV\tO\n-\tO\nDNA\tO\nlevel\tO\nwas\tO\ncontinuously\tO\nsuppressed\tO\n.\tO\n\nThese\tO\nvirological\tO\nresponses\tO\nwere\tO\nalso\tO\nmaintained\tO\neven\tO\nafter\tO\nthe\tO\nantiviral\tO\ntherapy\tO\nwas\tO\ndiscontinued\tO\n.\tO\n\nMoreover\tO\n,\tO\nboth\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nsurface\tI-Chemical\nantigen\tI-Chemical\nand\tI-Chemical\ne\tI-Chemical\nantigen\tI-Chemical\nwere\tO\nobserved\tO\nto\tO\nhave\tO\ndisappeared\tO\nin\tO\nthis\tO\npatient\tO\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nlamivudine\tB-Chemical\nto\tO\npatients\tO\nwith\tO\nHBV\tO\n-\tO\nrelated\tO\ncirrhosis\tB-Disease\n,\tO\nlike\tO\nour\tO\npresent\tO\ncase\tO\n,\tO\nshould\tO\nbe\tO\nconsidered\tO\nas\tO\nan\tO\ninitial\tO\nmedical\tO\ntherapeutic\tO\noption\tO\n,\tO\nespecially\tO\nin\tO\ncountries\tO\nwhere\tO\nliver\tO\ntransplantation\tO\nis\tO\nnot\tO\nreliably\tO\navailable\tO\n.\tO\n\nAntiarrhythmic\tO\neffects\tO\nof\tO\noptical\tO\nisomers\tO\nof\tO\ncibenzoline\tB-Chemical\non\tO\ncanine\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\n.\tO\n\nAntiarrhythmic\tO\neffects\tO\nof\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncibenzoline\tB-Chemical\nand\tO\n(\tO\n-\tO\n)\tO\n-\tO\ncibenzoline\tB-Chemical\nwere\tO\nexamined\tO\nusing\tO\ntwo\tO\ncanine\tO\nventricular\tB-Disease\narrhythmia\tI-Disease\nmodels\tO\n.\tO\n\nDigitalis\tB-Chemical\narrhythmia\tB-Disease\n,\tO\nwhich\tO\nis\tO\nsuppressed\tO\nby\tO\nNa\tB-Chemical\nchannel\tO\nblockers\tO\n,\tO\nwas\tO\ninduced\tO\nby\tO\nintermittent\tO\nintravenous\tO\n(\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\ninjection\tO\nof\tO\nouabain\tB-Chemical\nin\tO\npentobarbital\tB-Chemical\n-\tO\nanesthetized\tO\ndogs\tO\n.\tO\n\nAdrenaline\tB-Disease\narrhythmia\tI-Disease\n,\tO\nwhich\tO\nis\tO\nsuppressed\tO\nby\tO\nCa\tB-Chemical\nchannel\tO\nblockers\tO\n,\tO\nwas\tO\ninduced\tO\nby\tO\nadrenaline\tB-Chemical\ninfusion\tO\nin\tO\nhalothane\tB-Chemical\n-\tO\nanesthetized\tO\ndogs\tO\n.\tO\n\nTen\tO\nand\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncibenzoline\tB-Chemical\nsuppressed\tO\ndigitalis\tB-Chemical\n-\tO\nand\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\narrhythmias\tB-Disease\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nminimum\tO\neffective\tO\nplasma\tO\nconcentrations\tO\nof\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncibenzoline\tB-Chemical\nfor\tO\ndigitalis\tB-Chemical\n-\tO\nand\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\narrhythmias\tB-Disease\nwere\tO\n1\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n4\tO\nand\tO\n2\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n6\tO\nmicrograms\tO\n/\tO\nml\tO\n,\tO\nrespectively\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n,\tO\nn\tO\n=\tO\n6\tO\n)\tO\n.\tO\n\nA\tO\nlower\tO\ndose\tO\nof\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\nof\tO\n(\tO\n-\tO\n)\tO\n-\tO\ncibenzoline\tB-Chemical\nsuppressed\tO\nthe\tO\ndigitalis\tB-Chemical\n-\tO\ninduced\tO\narrhythmia\tB-Disease\n,\tO\nwhereas\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\nwas\tO\nneeded\tO\nto\tO\nsuppress\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\narrhythmias\tB-Disease\n.\tO\n\nThe\tO\nminimum\tO\neffective\tO\nplasma\tO\nconcentrations\tO\nof\tO\n(\tO\n-\tO\n)\tO\n-\tO\ncibenzoline\tB-Chemical\nfor\tO\ndigitalis\tB-Chemical\n-\tO\nand\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\narrhythmia\tB-Disease\nwere\tO\n0\tO\n.\tO\n06\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n04\tO\nand\tO\n0\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nmicrograms\tO\n/\tO\nml\tO\n,\tO\nrespectively\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n,\tO\nn\tO\n=\tO\n6\tO\n)\tO\n.\tO\n\nThe\tO\nstronger\tO\nantiarrhythmic\tO\neffect\tO\nof\tO\n(\tO\n-\tO\n)\tO\n-\tO\ncibenzoline\tB-Chemical\nindicates\tO\nthat\tO\n(\tO\n-\tO\n)\tO\n-\tO\nisomer\tO\nmay\tO\nhave\tO\nan\tO\neffect\tO\nnearly\tO\n5\tO\n-\tO\n20\tO\ntimes\tO\nstronger\tO\nin\tO\nsuppressing\tO\nNa\tB-Chemical\nchannels\tO\n,\tO\nbut\tO\neffects\tO\nof\tO\nboth\tO\ndrugs\tO\non\tO\nCa\tB-Chemical\nchannels\tO\nmay\tO\nbe\tO\nalmost\tO\nequipotent\tO\n.\tO\n\nPassage\tO\nof\tO\nmannitol\tB-Chemical\ninto\tO\nthe\tO\nbrain\tO\naround\tO\ngliomas\tB-Disease\n:\tO\na\tO\npotential\tO\ncause\tO\nof\tO\nrebound\tO\nphenomenon\tO\n.\tO\n\nA\tO\nstudy\tO\non\tO\n21\tO\npatients\tO\n.\tO\n\nAIM\tO\n:\tO\nWidespread\tO\nuse\tO\nof\tO\nmannitol\tB-Chemical\nto\tO\nreduce\tO\nbrain\tB-Disease\nedema\tI-Disease\nand\tO\nlower\tO\nelevated\tB-Disease\nICP\tI-Disease\nin\tO\nbrain\tB-Disease\ntumor\tI-Disease\npatients\tO\ncontinues\tO\nto\tO\nbe\tO\nafflicted\tO\nby\tO\nthe\tO\nso\tO\n-\tO\ncalled\tO\nrebound\tO\nphenomenon\tO\n.\tO\n\nLeakage\tO\nof\tO\nmannitol\tB-Chemical\ninto\tO\nthe\tO\nbrain\tO\nparenchyma\tO\nthrough\tO\nan\tO\naltered\tO\nBBB\tO\nand\tO\nsecondary\tO\nreversal\tO\nof\tO\nosmotic\tO\ngradient\tO\nis\tO\nconsidered\tO\nthe\tO\nmajor\tO\ncause\tO\nof\tO\nrebound\tO\n.\tO\n\nThis\tO\nhas\tO\nonly\tO\nbeen\tO\ndemonstrated\tO\nexperimentally\tO\nin\tO\nanimals\tO\n.\tO\n\nAs\tO\na\tO\ncontribution\tO\nto\tO\nthis\tO\nissue\tO\nwe\tO\ndecided\tO\nto\tO\nresearch\tO\nthe\tO\npossible\tO\npassage\tO\nof\tO\nmannitol\tB-Chemical\ninto\tO\nthe\tO\nbrain\tO\nafter\tO\nadministration\tO\nto\tO\n21\tO\nbrain\tB-Disease\ntumor\tI-Disease\npatients\tO\n.\tO\n\nMETHODS\tO\n:\tO\nMannitol\tB-Chemical\n(\tO\n18\tO\n%\tO\nsolution\tO\n;\tO\n1\tO\ng\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\nadministered\tO\nas\tO\na\tO\nbolus\tO\nto\tO\npatients\tO\n(\tO\nten\tO\nhad\tO\nmalignant\tB-Disease\nglioma\tI-Disease\n,\tO\nseven\tO\nbrain\tO\nmetastases\tB-Disease\nand\tO\nfour\tO\nmeningioma\tB-Disease\n)\tO\nabout\tO\n30\tO\nminutes\tO\nbefore\tO\ncraniotomy\tO\n.\tO\n\nDuring\tO\nresection\tO\n,\tO\na\tO\nsample\tO\nof\tO\nthe\tO\nsurrounding\tO\nedematous\tB-Disease\nwhite\tO\nmatter\tO\nwas\tO\ntaken\tO\nat\tO\nthe\tO\nsame\tO\ntime\tO\nas\tO\na\tO\n10\tO\nml\tO\nvenous\tO\nblood\tO\nsample\tO\n.\tO\n\nMannitol\tB-Chemical\nconcentrations\tO\nwere\tO\nmeasured\tO\nin\tO\nplasma\tO\nand\tO\nwhite\tO\nmatter\tO\nby\tO\na\tO\nmodified\tO\nversion\tO\nof\tO\nthe\tO\nenzyme\tO\nassay\tO\nof\tO\nBlonquist\tO\net\tO\nal\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIn\tO\nmost\tO\nglioma\tB-Disease\npatients\tO\n,\tO\nmannitol\tB-Chemical\nconcentrations\tO\nin\tO\nwhite\tO\nmatter\tO\nwere\tO\n2\tO\nto\tO\n6\tO\ntimes\tO\nhigher\tO\nthan\tO\nin\tO\nplasma\tO\n(\tO\nmean\tO\n3\tO\n.\tO\n5\tO\ntimes\tO\n)\tO\n.\tO\n\nIn\tO\nmeningioma\tB-Disease\nand\tO\nmetastases\tB-Disease\npatients\tO\nplasma\tO\nconcentrations\tO\nof\tO\nmannitol\tB-Chemical\nwere\tO\nhigher\tO\nthan\tO\nwhite\tO\nmatter\tO\nconcentrations\tO\nexcept\tO\nin\tO\nthree\tO\ncases\tO\nwith\tO\ninfiltration\tO\nby\tO\nneoplastic\tO\ncells\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nresults\tO\nof\tO\nour\tO\nstudy\tO\nshow\tO\nthat\tO\neven\tO\nafter\tO\na\tO\nsingle\tO\nbolus\tO\n,\tO\nmannitol\tB-Chemical\nmay\tO\nleak\tO\nthrough\tO\nthe\tO\naltered\tO\nBBB\tO\nnear\tO\ngliomas\tB-Disease\n,\tO\nreversing\tO\nthe\tO\ninitial\tO\nplasma\tO\n-\tO\nto\tO\n-\tO\nblood\tO\nosmotic\tO\ngradient\tO\n,\tO\naggravating\tO\nperitumoral\tO\nedema\tB-Disease\nand\tO\npromoting\tO\nrebound\tO\nof\tO\nICP\tO\n.\tO\n\nPlacebo\tO\n-\tO\nlevel\tO\nincidence\tO\nof\tO\nextrapyramidal\tB-Disease\nsymptoms\tI-Disease\n(\tO\nEPS\tB-Disease\n)\tO\nwith\tO\nquetiapine\tB-Chemical\nin\tO\ncontrolled\tO\nstudies\tO\nof\tO\npatients\tO\nwith\tO\nbipolar\tB-Disease\nmania\tI-Disease\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nevaluate\tO\nextrapyramidal\tB-Disease\nsymptoms\tI-Disease\n(\tO\nEPS\tB-Disease\n)\tO\n,\tO\nincluding\tO\nakathisia\tB-Disease\n,\tO\nwith\tO\nquetiapine\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nbipolar\tB-Disease\nmania\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nData\tO\nwere\tO\nanalyzed\tO\nfrom\tO\nfour\tO\nsimilarly\tO\ndesigned\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\n3\tO\n-\tO\nto\tO\n12\tO\n-\tO\nweek\tO\nstudies\tO\n.\tO\n\nTwo\tO\nstudies\tO\nevaluated\tO\nquetiapine\tB-Chemical\nmonotherapy\tO\n(\tO\nup\tO\nto\tO\n800\tO\nmg\tO\n/\tO\nday\tO\n)\tO\n(\tO\nn\tO\n=\tO\n209\tO\n)\tO\nversus\tO\nplacebo\tO\n(\tO\nn\tO\n=\tO\n198\tO\n)\tO\n,\tO\nwith\tO\nlithium\tB-Chemical\nor\tO\nhaloperidol\tB-Chemical\nmonotherapy\tO\nas\tO\nrespective\tO\nactive\tO\ncontrols\tO\n.\tO\n\nTwo\tO\nstudies\tO\nevaluated\tO\nquetiapine\tB-Chemical\n(\tO\nup\tO\nto\tO\n800\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nin\tO\ncombination\tO\nwith\tO\na\tO\nmood\tO\nstabilizer\tO\n(\tO\nlithium\tB-Chemical\nor\tO\ndivalproex\tB-Chemical\n,\tO\nQTP\tB-Chemical\n+\tO\nLi\tB-Chemical\n/\tO\nDVP\tB-Chemical\n)\tO\n(\tO\nn\tO\n=\tO\n196\tO\n)\tO\ncompared\tO\nto\tO\nplacebo\tO\nand\tO\nmood\tO\nstabilizer\tO\n(\tO\nPBO\tO\n+\tO\nLi\tB-Chemical\n/\tO\nDVP\tB-Chemical\n)\tO\n(\tO\nn\tO\n=\tO\n203\tO\n)\tO\n.\tO\n\nExtrapyramidal\tB-Disease\nsymptoms\tI-Disease\nwere\tO\nevaluated\tO\nusing\tO\nthe\tO\nSimpson\tO\n-\tO\nAngus\tO\nScale\tO\n(\tO\nSAS\tO\n)\tO\n,\tO\nthe\tO\nBarnes\tO\nAkathisia\tO\nRating\tO\nScale\tO\n(\tO\nBARS\tO\n)\tO\n,\tO\nadverse\tO\nevent\tO\nreports\tO\nand\tO\nanticholinergic\tO\ndrug\tO\nusage\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nincidence\tO\nof\tO\nEPS\tB-Disease\n-\tO\nrelated\tO\nadverse\tO\nevents\tO\n,\tO\nincluding\tO\nakathisia\tB-Disease\n,\tO\nwas\tO\nno\tO\ndifferent\tO\nwith\tO\nquetiapine\tB-Chemical\nmonotherapy\tO\n(\tO\n12\tO\n.\tO\n9\tO\n%\tO\n)\tO\nthan\tO\nwith\tO\nplacebo\tO\n(\tO\n13\tO\n.\tO\n1\tO\n%\tO\n)\tO\n.\tO\n\nSimilarly\tO\n,\tO\nEPS\tB-Disease\n-\tO\nrelated\tO\nadverse\tO\nevents\tO\nwith\tO\nQTP\tB-Chemical\n+\tO\nLi\tB-Chemical\n/\tO\nDVP\tB-Chemical\n(\tO\n21\tO\n.\tO\n4\tO\n%\tO\n)\tO\nwere\tO\nno\tO\ndifferent\tO\nthan\tO\nwith\tO\nPBO\tO\n+\tO\nLi\tB-Chemical\n/\tO\nDVP\tB-Chemical\n(\tO\n19\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nAdverse\tO\nevents\tO\nrelated\tO\nto\tO\nEPS\tB-Disease\noccurred\tO\nin\tO\n59\tO\n.\tO\n6\tO\n%\tO\nof\tO\npatients\tO\ntreated\tO\nwith\tO\nhaloperidol\tB-Chemical\n(\tO\nn\tO\n=\tO\n99\tO\n)\tO\nmonotherapy\tO\n,\tO\nwhereas\tO\n26\tO\n.\tO\n5\tO\n%\tO\nof\tO\npatients\tO\ntreated\tO\nwith\tO\nlithium\tB-Chemical\n(\tO\nn\tO\n=\tO\n98\tO\n)\tO\nmonotherapy\tO\nexperienced\tO\nadverse\tO\nevents\tO\nrelated\tO\nto\tO\nEPS\tB-Disease\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nakathisia\tB-Disease\nwas\tO\nlow\tO\nand\tO\nsimilar\tO\nwith\tO\nquetiapine\tB-Chemical\nmonotherapy\tO\n(\tO\n3\tO\n.\tO\n3\tO\n%\tO\n)\tO\nand\tO\nplacebo\tO\n(\tO\n6\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nand\tO\nwith\tO\nQTP\tB-Chemical\n+\tO\nLi\tB-Chemical\n/\tO\nDVP\tB-Chemical\n(\tO\n3\tO\n.\tO\n6\tO\n%\tO\n)\tO\nand\tO\nPBO\tO\n+\tO\nLi\tB-Chemical\n/\tO\nDVP\tB-Chemical\n(\tO\n4\tO\n.\tO\n9\tO\n%\tO\n)\tO\n.\tO\n\nLithium\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\na\tO\nsignificantly\tO\nhigher\tO\nincidence\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nof\tO\ntremor\tB-Disease\n(\tO\n18\tO\n.\tO\n4\tO\n%\tO\n)\tO\nthan\tO\nquetiapine\tB-Chemical\n(\tO\n5\tO\n.\tO\n6\tO\n%\tO\n)\tO\n;\tO\ncerebellar\tO\ntremor\tB-Disease\n,\tO\nwhich\tO\nis\tO\na\tO\nknown\tO\nadverse\tO\neffect\tO\nof\tO\nlithium\tB-Chemical\n,\tO\nmay\tO\nhave\tO\ncontributed\tO\nto\tO\nthe\tO\nelevated\tO\nrate\tO\nof\tO\ntremor\tB-Disease\nin\tO\npatients\tO\nreceiving\tO\nlithium\tB-Chemical\ntherapy\tO\n.\tO\n\nHaloperidol\tB-Chemical\ninduced\tO\na\tO\nsignificantly\tO\nhigher\tO\nincidence\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nof\tO\nakathisia\tB-Disease\n(\tO\n33\tO\n.\tO\n3\tO\n%\tO\nversus\tO\n5\tO\n.\tO\n9\tO\n%\tO\n)\tO\n,\tO\ntremor\tB-Disease\n(\tO\n30\tO\n.\tO\n3\tO\n%\tO\nversus\tO\n7\tO\n.\tO\n8\tO\n%\tO\n)\tO\n,\tO\nand\tO\nextrapyramidal\tB-Disease\nsyndrome\tI-Disease\n(\tO\n35\tO\n.\tO\n4\tO\n%\tO\nversus\tO\n5\tO\n.\tO\n9\tO\n%\tO\n)\tO\nthan\tO\nquetiapine\tB-Chemical\n.\tO\n\nNo\tO\nsignificant\tO\ndifferences\tO\nwere\tO\nobserved\tO\nbetween\tO\nquetiapine\tB-Chemical\nand\tO\nplacebo\tO\non\tO\nSAS\tO\nand\tO\nBARS\tO\nscores\tO\n.\tO\n\nAnticholinergic\tO\nuse\tO\nwas\tO\nlow\tO\nand\tO\nsimilar\tO\nwith\tO\nquetiapine\tB-Chemical\nor\tO\nplacebo\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\nbipolar\tB-Disease\nmania\tI-Disease\n,\tO\nthe\tO\nincidence\tO\nof\tO\nEPS\tB-Disease\n,\tO\nincluding\tO\nakathisia\tB-Disease\n,\tO\nwith\tO\nquetiapine\tB-Chemical\ntherapy\tO\nis\tO\nsimilar\tO\nto\tO\nthat\tO\nwith\tO\nplacebo\tO\n.\tO\n\nIs\tO\nphenytoin\tB-Chemical\nadministration\tO\nsafe\tO\nin\tO\na\tO\nhypothermic\tB-Disease\nchild\tO\n?\tO\n\nA\tO\nmale\tO\nneonate\tO\nwith\tO\na\tO\nChiari\tB-Disease\nmalformation\tI-Disease\nand\tO\na\tO\nleaking\tO\nmyelomeningocoele\tO\nunderwent\tO\nventriculoperitoneal\tO\nshunt\tO\ninsertion\tO\nfollowed\tO\nby\tO\nrepair\tO\nof\tO\nmyelomeningocoele\tO\n.\tO\n\nDuring\tO\nanaesthesia\tO\nand\tO\nsurgery\tO\n,\tO\nhe\tO\ninadvertently\tO\nbecame\tO\nmoderately\tO\nhypothermic\tB-Disease\n.\tO\n\nIntravenous\tO\nphenytoin\tB-Chemical\nwas\tO\nadministered\tO\nduring\tO\nthe\tO\nlater\tO\npart\tO\nof\tO\nthe\tO\nsurgery\tO\nfor\tO\nseizure\tB-Disease\nprophylaxis\tO\n.\tO\n\nFollowing\tO\nphenytoin\tB-Chemical\nadministration\tO\n,\tO\nthe\tO\npatient\tO\ndeveloped\tO\nacute\tO\nsevere\tO\nbradycardia\tB-Disease\n,\tO\nrefractory\tO\nto\tO\natropine\tB-Chemical\nand\tO\nadrenaline\tB-Chemical\n.\tO\n\nThe\tO\ncardiac\tO\ndepressant\tO\nactions\tO\nof\tO\nphenytoin\tB-Chemical\nand\tO\nhypothermia\tB-Disease\ncan\tO\nbe\tO\nadditive\tO\n.\tO\n\nAdministration\tO\nof\tO\nphenytoin\tB-Chemical\nin\tO\nthe\tO\npresence\tO\nof\tO\nhypothermia\tB-Disease\nmay\tO\nlead\tO\nto\tO\nan\tO\nadverse\tO\ncardiac\tO\nevent\tO\nin\tO\nchildren\tO\n.\tO\n\nAs\tO\nphenytoin\tB-Chemical\nis\tO\na\tO\ncommonly\tO\nused\tO\ndrug\tO\n,\tO\nclinicians\tO\nneed\tO\nto\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\ninteraction\tO\n.\tO\n\nValproate\tB-Chemical\n-\tO\ninduced\tO\nchorea\tB-Disease\nand\tO\nencephalopathy\tB-Disease\nin\tO\natypical\tO\nnonketotic\tB-Disease\nhyperglycinemia\tI-Disease\n.\tO\n\nNonketotic\tB-Disease\nhyperglycinemia\tI-Disease\nis\tO\na\tO\ndisorder\tB-Disease\nof\tI-Disease\namino\tI-Disease\nacid\tI-Disease\nmetabolism\tI-Disease\nin\tO\nwhich\tO\na\tO\ndefect\tO\nin\tO\nthe\tO\nglycine\tB-Chemical\ncleavage\tO\nsystem\tO\nleads\tO\nto\tO\nan\tO\naccumulation\tO\nof\tO\nglycine\tB-Chemical\nin\tO\nthe\tO\nbrain\tO\nand\tO\nother\tO\nbody\tO\ncompartments\tO\n.\tO\n\nIn\tO\nthe\tO\nclassical\tO\nform\tO\nit\tO\npresents\tO\nas\tO\nneonatal\tO\napnea\tB-Disease\n,\tO\nintractable\tO\nseizures\tB-Disease\n,\tO\nand\tO\nhypotonia\tB-Disease\n,\tO\nfollowed\tO\nby\tO\nsignificant\tO\npsychomotor\tB-Disease\nretardation\tI-Disease\n.\tO\n\nAn\tO\nimportant\tO\nsubset\tO\nof\tO\nchildren\tO\nwith\tO\nnonketotic\tB-Disease\nhyperglycinemia\tI-Disease\nare\tO\natypical\tO\nvariants\tO\nwho\tO\npresent\tO\nin\tO\na\tO\nheterogeneous\tO\nmanner\tO\n.\tO\n\nThis\tO\nreport\tO\ndescribes\tO\na\tO\npatient\tO\nwith\tO\nmild\tO\nlanguage\tB-Disease\ndelay\tI-Disease\nand\tO\nmental\tB-Disease\nretardation\tI-Disease\n,\tO\nwho\tO\nwas\tO\nfound\tO\nto\tO\nhave\tO\nnonketotic\tB-Disease\nhyperglycinemia\tI-Disease\nfollowing\tO\nher\tO\npresentation\tO\nwith\tO\nacute\tO\nencephalopathy\tB-Disease\nand\tO\nchorea\tB-Disease\nshortly\tO\nafter\tO\ninitiation\tO\nof\tO\nvalproate\tB-Chemical\ntherapy\tO\n.\tO\n\nDelayed\tO\ninstitution\tO\nof\tO\nhypertension\tB-Disease\nduring\tO\nfocal\tO\ncerebral\tB-Disease\nischemia\tI-Disease\n:\tO\neffect\tO\non\tO\nbrain\tB-Disease\nedema\tI-Disease\n.\tO\n\nThe\tO\neffect\tO\nof\tO\ninduced\tO\nhypertension\tB-Disease\ninstituted\tO\nafter\tO\na\tO\n2\tO\n-\tO\nh\tO\ndelay\tO\nfollowing\tO\nmiddle\tB-Disease\ncerebral\tI-Disease\nartery\tI-Disease\nocclusion\tI-Disease\n(\tO\nMCAO\tB-Disease\n)\tO\non\tO\nbrain\tB-Disease\nedema\tI-Disease\nformation\tO\nand\tO\nhistochemical\tO\ninjury\tO\nwas\tO\nstudied\tO\n.\tO\n\nUnder\tO\nisoflurane\tB-Chemical\nanesthesia\tO\n,\tO\nthe\tO\nMCA\tO\nof\tO\n14\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\nwas\tO\noccluded\tO\n.\tO\n\nIn\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\nn\tO\n=\tO\n7\tO\n)\tO\n,\tO\nthe\tO\nmean\tO\narterial\tO\npressure\tO\n(\tO\nMAP\tO\n)\tO\nwas\tO\nnot\tO\nmanipulated\tO\n.\tO\n\nIn\tO\nthe\tO\nhypertensive\tB-Disease\ngroup\tO\n(\tO\nn\tO\n=\tO\n7\tO\n)\tO\n,\tO\nthe\tO\nMAP\tO\nwas\tO\nelevated\tO\nby\tO\n25\tO\n-\tO\n30\tO\nmm\tO\nHg\tO\nbeginning\tO\n2\tO\nh\tO\nafter\tO\nMCAO\tB-Disease\n.\tO\n\nFour\tO\nhours\tO\nafter\tO\nMCAO\tB-Disease\n,\tO\nthe\tO\nrats\tO\nwere\tO\nkilled\tO\nand\tO\nthe\tO\nbrains\tO\nharvested\tO\n.\tO\n\nThe\tO\nbrains\tO\nwere\tO\nsectioned\tO\nalong\tO\ncoronal\tO\nplanes\tO\nspanning\tO\nthe\tO\ndistribution\tO\nof\tO\nischemia\tB-Disease\nproduced\tO\nby\tO\nMCAO\tB-Disease\n.\tO\n\nSpecific\tO\ngravity\tO\n(\tO\nSG\tO\n)\tO\nwas\tO\ndetermined\tO\nin\tO\nthe\tO\nsubcortex\tO\nand\tO\nin\tO\ntwo\tO\nsites\tO\nin\tO\nthe\tO\ncortex\tO\n(\tO\ncore\tO\nand\tO\nperiphery\tO\nof\tO\nthe\tO\nischemic\tB-Disease\nterritory\tO\n)\tO\n.\tO\n\nThe\tO\nextent\tO\nof\tO\nneuronal\tB-Disease\ninjury\tI-Disease\nwas\tO\ndetermined\tO\nby\tO\n2\tB-Chemical\n,\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\ntriphenyltetrazolium\tI-Chemical\nstaining\tO\n.\tO\n\nIn\tO\nthe\tO\nischemic\tB-Disease\ncore\tO\n,\tO\nthere\tO\nwas\tO\nno\tO\ndifference\tO\nin\tO\nSG\tO\nin\tO\nthe\tO\nsubcortex\tO\nand\tO\ncortex\tO\nin\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nIn\tO\nthe\tO\nperiphery\tO\nof\tO\nthe\tO\nischemic\tB-Disease\nterritory\tO\n,\tO\nSG\tO\nin\tO\nthe\tO\ncortex\tO\nwas\tO\ngreater\tO\n(\tO\nless\tO\nedema\tB-Disease\naccumulation\tO\n)\tO\nin\tO\nthe\tO\nhypertensive\tB-Disease\ngroup\tO\n(\tO\n1\tO\n.\tO\n041\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n001\tO\nvs\tO\n1\tO\n.\tO\n039\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n001\tO\n,\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\narea\tO\nof\tO\nhistochemical\tO\ninjury\tO\n(\tO\nas\tO\na\tO\npercent\tO\nof\tO\nthe\tO\ncross\tO\n-\tO\nsectional\tO\narea\tO\nof\tO\nthe\tO\nhemisphere\tO\n)\tO\nwas\tO\nless\tO\nin\tO\nthe\tO\nhypertensive\tB-Disease\ngroup\tO\n(\tO\n33\tO\n+\tO\n/\tO\n-\tO\n3\tO\n%\tO\nvs\tO\n21\tO\n+\tO\n/\tO\n-\tO\n2\tO\n%\tO\n,\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\ndata\tO\nindicate\tO\nthat\tO\nphenylephrine\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\ninstituted\tO\n2\tO\nh\tO\nafter\tO\nMCAO\tB-Disease\ndoes\tO\nnot\tO\naggravate\tO\nedema\tB-Disease\nin\tO\nthe\tO\nischemic\tB-Disease\ncore\tO\n,\tO\nthat\tO\nit\tO\nimproves\tO\nedema\tB-Disease\nin\tO\nthe\tO\nperiphery\tO\nof\tO\nthe\tO\nischemic\tB-Disease\nterritory\tO\n,\tO\nand\tO\nthat\tO\nit\tO\nreduces\tO\nthe\tO\narea\tO\nof\tO\nhistochemical\tO\nneuronal\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nBehavioral\tO\neffects\tO\nof\tO\npubertal\tO\nanabolic\tO\nandrogenic\tO\nsteroid\tB-Chemical\nexposure\tO\nin\tO\nmale\tO\nrats\tO\nwith\tO\nlow\tO\nserotonin\tB-Chemical\n.\tO\n\nThe\tO\ngoal\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nassess\tO\nthe\tO\ninteractive\tO\neffects\tO\nof\tO\nchronic\tO\nanabolic\tO\nandrogenic\tO\nsteroid\tB-Chemical\n(\tO\nAAS\tO\n)\tO\nexposure\tO\nand\tO\nbrain\tO\nserotonin\tB-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptamine\tI-Chemical\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n)\tO\ndepletion\tO\non\tO\nbehavior\tO\nof\tO\npubertal\tO\nmale\tO\nrats\tO\n.\tO\n\nSerotonin\tB-Chemical\nwas\tO\ndepleted\tO\nbeginning\tO\non\tO\npostnatal\tO\nday\tO\n26\tO\nwith\tO\nparachlorophenylalanine\tB-Chemical\n(\tO\nPCPA\tB-Chemical\n100\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nevery\tO\nother\tO\nday\tO\n)\tO\n;\tO\ncontrols\tO\nreceived\tO\nsaline\tO\n.\tO\n\nAt\tO\npuberty\tO\n(\tO\nP40\tO\n)\tO\n,\tO\nhalf\tO\nthe\tO\nPCPA\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nand\tO\nhalf\tO\nthe\tO\nsaline\tO\n-\tO\ntreated\tO\nrats\tO\nbegan\tO\ntreatment\tO\nwith\tO\ntestosterone\tB-Chemical\n(\tO\nT\tB-Chemical\n,\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\n5\tO\ndays\tO\n/\tO\nweek\tO\n)\tO\n.\tO\n\nBehavioral\tO\nmeasures\tO\nincluded\tO\nlocomotion\tO\n,\tO\nirritability\tB-Disease\n,\tO\ncopulation\tO\n,\tO\npartner\tO\npreference\tO\n,\tO\nand\tO\naggression\tB-Disease\n.\tO\n\nAnimals\tO\nwere\tO\ntested\tO\nfor\tO\naggression\tB-Disease\nin\tO\ntheir\tO\nhome\tO\ncage\tO\n,\tO\nboth\tO\nwith\tO\nand\tO\nwithout\tO\nphysical\tO\nprovocation\tO\n(\tO\nmild\tO\ntail\tO\npinch\tO\n)\tO\n.\tO\n\nBrain\tO\nlevels\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\nand\tO\nits\tO\nmetabolite\tO\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxyindoleacetic\tI-Chemical\nacid\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHIAA\tI-Chemical\n)\tO\n,\tO\nwere\tO\ndetermined\tO\nusing\tO\nHPLC\tO\n.\tO\n\nPCPA\tB-Chemical\nsignificantly\tO\nand\tO\nsubstantially\tO\ndepleted\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\nand\tO\n5\tB-Chemical\n-\tI-Chemical\nHIAA\tI-Chemical\nin\tO\nall\tO\nbrain\tO\nregions\tO\nexamined\tO\n.\tO\n\nChronic\tO\nT\tB-Chemical\ntreatment\tO\nsignificantly\tO\ndecreased\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\nand\tO\n5\tB-Chemical\n-\tI-Chemical\nHIAA\tI-Chemical\nin\tO\ncertain\tO\nbrain\tO\nareas\tO\n,\tO\nbut\tO\nto\tO\na\tO\nmuch\tO\nlesser\tO\nextent\tO\nthan\tO\nPCPA\tB-Chemical\n.\tO\n\nChronic\tO\nexposure\tO\nto\tO\nPCPA\tB-Chemical\nalone\tO\nsignificantly\tO\ndecreased\tO\nlocomotor\tO\nactivity\tO\nand\tO\nincreased\tO\nirritability\tB-Disease\nbut\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nsexual\tO\nbehavior\tO\n,\tO\npartner\tO\npreference\tO\n,\tO\nor\tO\naggression\tB-Disease\n.\tO\n\nT\tB-Chemical\nalone\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nlocomotion\tO\n,\tO\nirritability\tB-Disease\n,\tO\nor\tO\nsexual\tO\nbehavior\tO\nbut\tO\nincreased\tO\npartner\tO\npreference\tO\nand\tO\naggression\tB-Disease\n.\tO\n\nThe\tO\nmost\tO\nstriking\tO\neffect\tO\nof\tO\ncombining\tO\nT\tB-Chemical\n+\tO\nPCPA\tB-Chemical\nwas\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nattack\tO\nfrequency\tO\nas\tO\nwell\tO\nas\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nthe\tO\nlatency\tO\nto\tO\nattack\tO\n,\tO\nparticularly\tO\nfollowing\tO\nphysical\tO\nprovocation\tO\n.\tO\n\nBased\tO\non\tO\nthese\tO\ndata\tO\n,\tO\nit\tO\ncan\tO\nbe\tO\nspeculated\tO\nthat\tO\npubertal\tO\nAAS\tO\nusers\tO\nwith\tO\nlow\tO\ncentral\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\nmay\tO\nbe\tO\nespecially\tO\nprone\tO\nto\tO\nexhibit\tO\naggressive\tB-Disease\nbehavior\tI-Disease\n.\tO\n\nEffects\tO\nof\tO\nUMB24\tB-Chemical\nand\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nSM\tB-Chemical\n21\tI-Chemical\n,\tO\nputative\tO\nsigma2\tO\n-\tO\npreferring\tO\nantagonists\tO\n,\tO\non\tO\nbehavioral\tO\ntoxic\tO\nand\tO\nstimulant\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\nin\tO\nmice\tO\n.\tO\n\nEarlier\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nthat\tO\nantagonism\tO\nof\tO\nsigma1\tO\nreceptors\tO\nattenuates\tO\nthe\tO\nconvulsive\tB-Disease\n,\tO\nlethal\tO\n,\tO\nlocomotor\tO\nstimulatory\tO\nand\tO\nrewarding\tO\nactions\tO\nof\tO\ncocaine\tB-Chemical\nin\tO\nmice\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthe\tO\ncontribution\tO\nof\tO\nsigma2\tO\nreceptors\tO\nis\tO\nunclear\tO\nbecause\tO\nexperimental\tO\ntools\tO\nto\tO\nselectively\tO\ntarget\tO\nthis\tO\nsubtype\tO\nare\tO\nunavailable\tO\n.\tO\n\nTo\tO\nbegin\tO\naddressing\tO\nthis\tO\nneed\tO\n,\tO\nwe\tO\ncharacterized\tO\nUMB24\tB-Chemical\n(\tO\n1\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nphenethyl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\npyridyl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\npiperazine\tI-Chemical\n)\tO\nand\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nSM\tB-Chemical\n21\tI-Chemical\n(\tO\n3alpha\tB-Chemical\n-\tI-Chemical\ntropanyl\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nchorophenoxy\tI-Chemical\n)\tI-Chemical\nbutyrate\tI-Chemical\n)\tO\nin\tO\nreceptor\tO\nbinding\tO\nand\tO\nbehavioral\tO\nstudies\tO\n.\tO\n\nReceptor\tO\nbinding\tO\nstudies\tO\nconfirmed\tO\nthat\tO\nUMB24\tB-Chemical\nand\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nSM\tB-Chemical\n21\tI-Chemical\ndisplay\tO\npreferential\tO\naffinity\tO\nfor\tO\nsigma2\tO\nover\tO\nsigma1\tO\nreceptors\tO\n.\tO\n\nIn\tO\nbehavioral\tO\nstudies\tO\n,\tO\npretreatment\tO\nof\tO\nSwiss\tO\nWebster\tO\nmice\tO\nwith\tO\nUMB24\tB-Chemical\nor\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nSM\tB-Chemical\n21\tI-Chemical\nsignificantly\tO\nattenuated\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nand\tO\nlocomotor\tO\nactivity\tO\n,\tO\nbut\tO\nnot\tO\nlethality\tO\n.\tO\n\nWhen\tO\nadministered\tO\nalone\tO\n,\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nSM\tB-Chemical\n21\tI-Chemical\nproduced\tO\nno\tO\nsignificant\tO\neffects\tO\ncompared\tO\nto\tO\ncontrol\tO\ninjections\tO\nof\tO\nsaline\tO\n,\tO\nbut\tO\nUMB24\tB-Chemical\nhad\tO\nlocomotor\tO\ndepressant\tO\nactions\tO\n.\tO\n\nTogether\tO\n,\tO\nthe\tO\ndata\tO\nsuggest\tO\nthat\tO\nsigma2\tO\nreceptor\tO\nantagonists\tO\nhave\tO\nthe\tO\npotential\tO\nto\tO\nattenuate\tO\nsome\tO\nof\tO\nthe\tO\nbehavioral\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\n,\tO\nand\tO\nfurther\tO\ndevelopment\tO\nof\tO\nmore\tO\nselective\tO\n,\tO\nhigh\tO\naffinity\tO\nligands\tO\nare\tO\nwarranted\tO\n.\tO\n\nCardiac\tB-Disease\narrest\tI-Disease\nin\tO\na\tO\nchild\tO\nwith\tO\ncerebral\tB-Disease\npalsy\tI-Disease\nundergoing\tO\nsevoflurane\tB-Chemical\ninduction\tO\nof\tO\nanesthesia\tO\nafter\tO\npreoperative\tO\nclonidine\tB-Chemical\n.\tO\n\nClonidine\tB-Chemical\nis\tO\na\tO\nfrequently\tO\nadministered\tO\nalpha2\tO\n-\tO\nadrenergic\tO\nagonist\tO\nwhich\tO\ncan\tO\ndecrease\tO\nheart\tO\nrate\tO\nand\tO\nblood\tO\npressure\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\ncase\tO\nof\tO\na\tO\n5\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nchild\tO\nwith\tO\ncerebral\tB-Disease\npalsy\tI-Disease\nand\tO\nseizure\tB-Disease\ndisorder\tI-Disease\n,\tO\nreceiving\tO\nclonidine\tB-Chemical\nfor\tO\nrestlessness\tB-Disease\n,\tO\nwho\tO\npresented\tO\nfor\tO\nplacement\tO\nof\tO\na\tO\nbaclofen\tB-Chemical\npump\tO\n.\tO\n\nWithout\tO\nthe\tO\nknowledge\tO\nof\tO\nthe\tO\nmedical\tO\npersonnel\tO\n,\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nmother\tO\nadministered\tO\nthree\tO\ndoses\tO\nof\tO\nclonidine\tB-Chemical\nduring\tO\nthe\tO\nevening\tO\nbefore\tO\nand\tO\nmorning\tO\nof\tO\nsurgery\tO\nto\tO\nreduce\tO\nanxiety\tB-Disease\n.\tO\n\nDuring\tO\ninduction\tO\nof\tO\nanesthesia\tO\n,\tO\nthe\tO\npatient\tO\ndeveloped\tO\nbradycardia\tB-Disease\nand\tO\nhypotension\tB-Disease\nrequiring\tO\ncardiac\tO\nresuscitation\tO\n.\tO\n\nThere\tO\nare\tO\nno\tO\nprevious\tO\nreports\tO\nof\tO\nclonidine\tB-Chemical\n-\tO\nassociated\tO\ncardiac\tB-Disease\narrest\tI-Disease\nin\tO\na\tO\nchild\tO\nundergoing\tO\ninduction\tO\nof\tO\nanesthesia\tO\n.\tO\n\nAngiotensin\tO\n-\tO\nconverting\tO\nenzyme\tO\n(\tO\nACE\tO\n)\tO\ninhibitor\tO\n-\tO\nassociated\tO\nangioedema\tB-Disease\nof\tO\nthe\tO\nstomach\tO\nand\tO\nsmall\tO\nintestine\tO\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\ncase\tO\nreport\tO\non\tO\na\tO\n45\tO\n-\tO\nyear\tO\nold\tO\nAfrican\tO\n-\tO\nAmerican\tO\nfemale\tO\nwith\tO\nnewly\tO\ndiagnosed\tO\nhypertension\tB-Disease\n,\tO\nwho\tO\nwas\tO\nstarted\tO\non\tO\na\tO\ncombination\tO\npill\tO\nof\tO\namlodipine\tB-Chemical\n/\tO\nbenazapril\tB-Chemical\n10\tO\n/\tO\n5\tO\nmg\tO\n.\tO\n\nThe\tO\nvery\tO\nnext\tO\nday\tO\n,\tO\nshe\tO\npresented\tO\nat\tO\nthe\tO\nemergency\tO\nroom\tO\n(\tO\nER\tO\n)\tO\nwith\tO\nabdominal\tB-Disease\npain\tI-Disease\n,\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\n.\tO\n\nPhysical\tO\nexam\tO\n,\tO\ncomplete\tO\nmetabolic\tO\npanel\tO\n,\tO\nand\tO\nhemogram\tO\nwere\tO\nin\tO\nthe\tO\nnormal\tO\nrange\tO\n.\tO\n\nShe\tO\nwas\tO\ndischarged\tO\nfrom\tO\nthe\tO\nER\tO\nafter\tO\na\tO\nfew\tO\nhours\tO\nof\tO\ntreatment\tO\nwith\tO\nfluid\tO\nand\tO\nanalgesics\tO\n.\tO\n\nHowever\tO\n,\tO\nshe\tO\nreturned\tO\nto\tO\nthe\tO\nER\tO\nthe\tO\nnext\tO\nday\tO\nwith\tO\nthe\tO\nsame\tO\ncomplaints\tO\n.\tO\n\nThis\tO\ntime\tO\nthe\tO\nphysical\tO\nexam\tO\nwas\tO\nsignificant\tO\nfor\tO\na\tO\ndistended\tO\nabdomen\tO\nwith\tO\ndullness\tO\nto\tO\npercussion\tO\n.\tO\n\nCT\tO\nscan\tO\nof\tO\nthe\tO\nabdomen\tO\nrevealed\tO\nmarkedly\tO\nthickened\tO\nantrum\tO\nof\tO\nthe\tO\nstomach\tO\n,\tO\nduodenum\tO\nand\tO\njejunum\tO\n,\tO\nalong\tO\nwith\tO\nfluid\tO\nin\tO\nthe\tO\nabdominal\tO\nand\tO\npelvic\tO\ncavity\tO\n.\tO\n\nAngiotensin\tO\n-\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\n(\tO\nACEI\tO\n)\tO\n-\tO\ninduced\tO\nangioedema\tB-Disease\nwas\tO\nsuspected\tO\n,\tO\nand\tO\nanti\tO\n-\tO\nhypertensive\tB-Disease\nmedications\tO\nwere\tO\ndiscontinued\tO\n.\tO\n\nHer\tO\nsymptoms\tO\nimproved\tO\nwithin\tO\nthe\tO\nnext\tO\n24\tO\nhours\tO\n,\tO\nand\tO\nrepeat\tO\nCT\tO\nafter\tO\n72\tO\nhours\tO\nrevealed\tO\nmarked\tO\nimprovement\tO\nin\tO\nstomach\tO\nand\tO\nsmall\tO\nbowel\tO\nthickening\tO\nand\tO\nresolution\tO\nof\tO\nascites\tB-Disease\n.\tO\n\nThe\tO\nrecognition\tO\nof\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\n(\tO\nACE\tO\n)\tO\nand\tO\nangiotensin\tB-Chemical\nreceptor\tO\nblocker\tO\n(\tO\nARB\tO\n)\tO\nintestinal\tB-Disease\nangioedema\tI-Disease\nconstitutes\tO\na\tO\nchallenge\tO\nto\tO\nprimary\tO\ncare\tO\nphysicians\tO\n,\tO\ninternists\tO\n,\tO\nemergency\tO\nroom\tO\npersonal\tO\nand\tO\nsurgeons\tO\n.\tO\n\nCarbamazepine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nCharacterization\tO\nof\tO\ntwo\tO\ndistinct\tO\nclinical\tO\nsyndromes\tO\n.\tO\n\nA\tO\npatient\tO\nwith\tO\nsinus\tO\nbradycardia\tB-Disease\nand\tO\natrioventricular\tB-Disease\nblock\tI-Disease\n,\tO\ninduced\tO\nby\tO\ncarbamazepine\tB-Chemical\n,\tO\nprompted\tO\nan\tO\nextensive\tO\nliterature\tO\nreview\tO\nof\tO\nall\tO\npreviously\tO\nreported\tO\ncases\tO\n.\tO\n\nFrom\tO\nthe\tO\nanalysis\tO\nof\tO\nthese\tO\ncases\tO\n,\tO\ntwo\tO\ndistinct\tO\nforms\tO\nof\tO\ncarbamazepine\tB-Chemical\n-\tO\nassociated\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\nemerged\tO\n.\tO\n\nOne\tO\npatient\tO\ngroup\tO\ndeveloped\tO\nsinus\tB-Disease\ntachycardias\tI-Disease\nin\tO\nthe\tO\nsetting\tO\nof\tO\na\tO\nmassive\tO\ncarbamazepine\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nThe\tO\nsecond\tO\ngroup\tO\nconsisted\tO\nalmost\tO\nexclusively\tO\nof\tO\nelderly\tO\nwomen\tO\nwho\tO\ndeveloped\tO\npotentially\tO\nlife\tO\n-\tO\nthreatening\tO\nbradyarrhythmias\tB-Disease\nor\tO\natrioventricular\tB-Disease\nconduction\tI-Disease\ndelay\tI-Disease\n,\tO\nassociated\tO\nwith\tO\neither\tO\ntherapeutic\tO\nor\tO\nmodestly\tO\nelevated\tO\ncarbamazepine\tB-Chemical\nserum\tO\nlevels\tO\n.\tO\n\nBecause\tO\ncarbamazepine\tB-Chemical\nis\tO\nwidely\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nmany\tO\nneurologic\tO\nand\tO\npsychiatric\tB-Disease\nconditions\tO\n,\tO\nthe\tO\nrecognition\tO\nof\tO\nthe\tO\nlatter\tO\nsyndrome\tO\nhas\tO\nimportant\tO\nimplications\tO\nfor\tO\nthe\tO\nuse\tO\nof\tO\nthis\tO\ndrug\tO\nin\tO\nelderly\tO\npatients\tO\n.\tO\n\nDetection\tO\nof\tO\nabnormal\tO\ncardiac\tO\nadrenergic\tO\nneuron\tO\nactivity\tO\nin\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\nwith\tO\niodine\tB-Chemical\n-\tI-Chemical\n125\tI-Chemical\n-\tI-Chemical\nmetaiodobenzylguanidine\tI-Chemical\n.\tO\n\nRadiolabeled\tB-Chemical\nmetaiodobenzylguanidine\tI-Chemical\n(\tO\nMIBG\tB-Chemical\n)\tO\n,\tO\nan\tO\nanalog\tO\nof\tO\nnorepinephrine\tB-Chemical\n(\tO\nNE\tB-Chemical\n)\tO\n,\tO\nserves\tO\nas\tO\nan\tO\nindex\tO\nof\tO\nadrenergic\tO\nneuron\tO\nintegrity\tO\nand\tO\nfunction\tO\n.\tO\n\nUsing\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\n,\tO\nwe\tO\ntested\tO\nthe\tO\nhypothesis\tO\nthat\tO\nabnormal\tO\ncardiac\tO\nadrenergic\tO\nneuron\tO\nactivity\tO\nmay\tO\nappear\tO\nand\tO\nbe\tO\nexacerbated\tO\ndose\tO\n-\tO\ndependently\tO\nin\tO\nadriamycin\tB-Chemical\ncardiomyopathy\tB-Disease\n.\tO\n\nThe\tO\ndegree\tO\nof\tO\nvacuolar\tB-Disease\ndegeneration\tI-Disease\nof\tI-Disease\nmyocardial\tI-Disease\ncells\tI-Disease\nwas\tO\nanalyzed\tO\nin\tO\nrelation\tO\nto\tO\nthe\tO\nduration\tO\nof\tO\nadriamycin\tB-Chemical\ntreatment\tO\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nonce\tO\na\tO\nweek\tO\n)\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nabnormalities\tO\nor\tO\nonly\tO\nisolated\tO\ndegeneration\tO\nin\tO\nthe\tO\n1\tO\n-\tO\nor\tO\n2\tO\n-\tO\nwk\tO\ntreatment\tO\ngroups\tO\n,\tO\nisolated\tO\nor\tO\nscattered\tO\ndegeneration\tO\nin\tO\nhalf\tO\nof\tO\nthe\tO\n3\tO\n-\tO\nwk\tO\ngroup\tO\n,\tO\nfrequent\tO\nscattered\tO\ndegeneration\tO\nin\tO\nthe\tO\n4\tO\n-\tO\nwk\tO\ngroup\tO\n,\tO\nscattered\tO\nor\tO\nfocal\tO\ndegeneration\tO\nin\tO\nthe\tO\n5\tO\n-\tO\nwk\tO\ngroup\tO\n,\tO\nand\tO\nextensive\tO\ndegeneration\tO\nin\tO\nthe\tO\n8\tO\n-\tO\nwk\tO\ngroup\tO\n.\tO\n\nMyocardial\tO\naccumulation\tO\nof\tO\n[\tO\n125I\tO\n]\tO\nMIBG\tB-Chemical\n4\tO\nhr\tO\nafter\tO\nintravenous\tO\ninjection\tO\ndid\tO\nnot\tO\ndiffer\tO\nbetween\tO\nthe\tO\ncontrols\tO\nand\tO\nthe\tO\ngroups\tO\ntreated\tO\n3\tO\nwk\tO\nor\tO\nless\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\n4\tO\n-\tO\nwk\tO\ngroup\tO\nhad\tO\na\tO\nslightly\tO\nlower\tO\naccumulation\tO\nin\tO\nthe\tO\nright\tO\nventricular\tO\nwall\tO\n(\tO\n82\tO\n%\tO\nof\tO\nthe\tO\ncontrol\tO\n)\tO\nand\tO\nsignificantly\tO\nlower\tO\naccumulation\tO\nin\tO\nthe\tO\nleft\tO\nventricular\tO\nwall\tO\n(\tO\nabout\tO\n66\tO\n%\tO\nof\tO\nthe\tO\ncontrol\tO\n:\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\n5\tO\n-\tO\nwk\tO\ngroup\tO\n,\tO\nMIBG\tB-Chemical\naccumulation\tO\nin\tO\nthe\tO\nright\tO\nand\tO\nleft\tO\nventricular\tO\nwall\tO\nwas\tO\n35\tO\n%\tO\nand\tO\n27\tO\n%\tO\nof\tO\nthat\tO\nin\tO\ncontrols\tO\n,\tO\nrespectively\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\n8\tO\n-\tO\nwk\tO\ngroup\tO\n,\tO\nMIBG\tB-Chemical\naccumulation\tO\nin\tO\nthe\tO\nright\tO\nand\tO\nleft\tO\nventricular\tO\nwall\tO\nwas\tO\n18\tO\n%\tO\nand\tO\n14\tO\n%\tO\nof\tO\nthat\tO\nin\tO\ncontrols\tO\n,\tO\nrespectively\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThus\tO\n,\tO\nMIBG\tB-Chemical\naccumulation\tO\nin\tO\nthe\tO\nmyocardium\tO\ndecreased\tO\nin\tO\nan\tO\nadriamycin\tB-Chemical\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nThe\tO\nappearance\tO\nof\tO\nimpaired\tO\ncardiac\tO\nadrenergic\tO\nneuron\tO\nactivity\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nslight\tO\nmyocardial\tB-Disease\nimpairment\tI-Disease\n(\tO\nscattered\tO\nor\tO\nfocal\tO\nvacuolar\tB-Disease\ndegeneration\tI-Disease\n)\tO\nindicates\tO\nthat\tO\nMIBG\tB-Chemical\nscintigraphy\tO\nmay\tO\nbe\tO\na\tO\nuseful\tO\nmethod\tO\nfor\tO\ndetection\tO\nof\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\n.\tO\n\nSyncope\tB-Disease\nand\tO\nQT\tB-Disease\nprolongation\tI-Disease\namong\tO\npatients\tO\ntreated\tO\nwith\tO\nmethadone\tB-Chemical\nfor\tO\nheroin\tB-Chemical\ndependence\tO\nin\tO\nthe\tO\ncity\tO\nof\tO\nCopenhagen\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nMethadone\tB-Chemical\nis\tO\nprescribed\tO\nto\tO\nheroin\tB-Chemical\naddicts\tO\nto\tO\ndecrease\tO\nillicit\tO\nopioid\tO\nuse\tO\n.\tO\n\nProlongation\tO\nof\tO\nthe\tO\nQT\tO\ninterval\tO\nin\tO\nthe\tO\nECG\tO\nof\tO\npatients\tO\nwith\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\nTdP\tB-Disease\n)\tO\nhas\tO\nbeen\tO\nreported\tO\nin\tO\nmethadone\tB-Chemical\nusers\tO\n.\tO\n\nAs\tO\nheroin\tB-Chemical\naddicts\tO\nsometimes\tO\nfaint\tO\nwhile\tO\nusing\tO\nillicit\tO\ndrugs\tO\n,\tO\ndoctors\tO\nmight\tO\nattribute\tO\ntoo\tO\nmany\tO\nepisodes\tO\nof\tO\nsyncope\tB-Disease\nto\tO\nillicit\tO\ndrug\tO\nuse\tO\nand\tO\nthereby\tO\nunderestimate\tO\nthe\tO\nincidence\tO\nof\tO\nTdP\tB-Disease\nin\tO\nthis\tO\nspecial\tO\npopulation\tO\n,\tO\nand\tO\nthe\tO\nhigh\tO\nmortality\tO\nin\tO\nthis\tO\npopulation\tO\nmay\tO\n,\tO\nin\tO\npart\tO\n,\tO\nbe\tO\ncaused\tO\nby\tO\nthe\tO\nproarrhythmic\tO\neffect\tO\nof\tO\nmethadone\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nIn\tO\nthis\tO\ncross\tO\n-\tO\nsectional\tO\nstudy\tO\ninterview\tO\n,\tO\nECGs\tO\nand\tO\nblood\tO\nsamples\tO\nwere\tO\ncollected\tO\nin\tO\na\tO\npopulation\tO\nof\tO\nadult\tO\nheroin\tB-Chemical\naddicts\tO\ntreated\tO\nwith\tO\nmethadone\tB-Chemical\nor\tO\nbuprenorphine\tB-Chemical\non\tO\na\tO\ndaily\tO\nbasis\tO\n.\tO\n\nOf\tO\nthe\tO\npatients\tO\nat\tO\nthe\tO\nDrug\tO\nAddiction\tO\nService\tO\nin\tO\nthe\tO\nmunicipal\tO\nof\tO\nCopenhagen\tO\n,\tO\n450\tO\n(\tO\napproximately\tO\n52\tO\n%\tO\n)\tO\nwere\tO\nincluded\tO\n.\tO\n\nThe\tO\nQT\tO\ninterval\tO\nwas\tO\nestimated\tO\nfrom\tO\n12\tO\nlead\tO\nECGs\tO\n.\tO\n\nAll\tO\nparticipants\tO\nwere\tO\ninterviewed\tO\nabout\tO\nany\tO\nexperience\tO\nof\tO\nsyncope\tB-Disease\n.\tO\n\nThe\tO\nassociation\tO\nbetween\tO\nopioid\tO\ndose\tO\nand\tO\nQT\tO\n,\tO\nand\tO\nmethadone\tB-Chemical\ndose\tO\nand\tO\nreporting\tO\nof\tO\nsyncope\tB-Disease\nwas\tO\nassessed\tO\nusing\tO\nmultivariate\tO\nlinear\tO\nregression\tO\nand\tO\nlogistic\tO\nregression\tO\n,\tO\nrespectively\tO\n.\tO\n\nRESULTS\tO\n:\tO\nMethadone\tB-Chemical\ndose\tO\nwas\tO\nassociated\tO\nwith\tO\nlonger\tO\nQT\tO\ninterval\tO\nof\tO\n0\tO\n.\tO\n140\tO\nms\tO\n/\tO\nmg\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nNo\tO\nassociation\tO\nbetween\tO\nbuprenorphine\tB-Chemical\nand\tO\nQTc\tO\nwas\tO\nfound\tO\n.\tO\n\nAmong\tO\nthe\tO\nsubjects\tO\ntreated\tO\nwith\tO\nmethadone\tB-Chemical\n,\tO\n28\tO\n%\tO\nmen\tO\nand\tO\n32\tO\n%\tO\nwomen\tO\nhad\tO\nprolonged\tB-Disease\nQTc\tI-Disease\ninterval\tI-Disease\n.\tO\n\nNone\tO\nof\tO\nthe\tO\nsubjects\tO\ntreated\tO\nwith\tO\nbuprenorphine\tB-Chemical\nhad\tO\nQTc\tO\ninterval\tO\n>\tO\n0\tO\n.\tO\n440\tO\ns\tO\n(\tO\n(\tO\n1\tO\n/\tO\n2\tO\n)\tO\n)\tO\n.\tO\n\nA\tO\n50\tO\nmg\tO\nhigher\tO\nmethadone\tB-Chemical\ndose\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\n1\tO\n.\tO\n2\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n1\tO\nto\tO\n1\tO\n.\tO\n4\tO\n)\tO\ntimes\tO\nhigher\tO\nodds\tO\nfor\tO\nsyncope\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nMethadone\tB-Chemical\nis\tO\nassociated\tO\nwith\tO\nQT\tB-Disease\nprolongation\tI-Disease\nand\tO\nhigher\tO\nreporting\tO\nof\tO\nsyncope\tB-Disease\nin\tO\na\tO\npopulation\tO\nof\tO\nheroin\tB-Chemical\naddicts\tO\n.\tO\n\nNeuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\ninduced\tO\nby\tO\nziprasidone\tB-Chemical\non\tO\nthe\tO\nsecond\tO\nday\tO\nof\tO\ntreatment\tO\n.\tO\n\nNeuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\n(\tO\nNMS\tB-Disease\n)\tO\nis\tO\nthe\tO\nrarest\tO\nand\tO\nmost\tO\nserious\tO\nof\tO\nthe\tO\nneuroleptic\tO\n-\tO\ninduced\tO\nmovement\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\n(\tO\nNMS\tB-Disease\n)\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nziprasidone\tB-Chemical\n.\tO\n\nAlthough\tO\nconventional\tO\nneuroleptics\tO\nare\tO\nmore\tO\nfrequently\tO\nassociated\tO\nwith\tO\nNMS\tB-Disease\n,\tO\natypical\tO\nantipsychotic\tO\ndrugs\tO\nlike\tO\nziprasidone\tB-Chemical\nmay\tO\nalso\tO\nbe\tO\na\tO\ncause\tO\n.\tO\n\nThe\tO\npatient\tO\nis\tO\na\tO\n24\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nschizophrenia\tB-Disease\nwho\tO\ndeveloped\tO\nsigns\tO\nand\tO\nsymptoms\tO\nof\tO\nNMS\tB-Disease\nafter\tO\n2\tO\ndays\tO\nof\tO\ntreatment\tO\nwith\tO\nan\tO\n80\tO\n-\tO\nmg\tO\n/\tO\nday\tO\ndose\tO\nof\tO\norally\tO\nadministrated\tO\nziprasidone\tB-Chemical\n.\tO\n\nThis\tO\ncase\tO\nis\tO\nthe\tO\nearliest\tO\n(\tO\nsecond\tO\nday\tO\nof\tO\ntreatment\tO\n)\tO\nNMS\tB-Disease\ndue\tO\nto\tO\nziprasidone\tB-Chemical\nreported\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nPeripheral\tO\niron\tB-Chemical\ndextran\tI-Chemical\ninduced\tO\ndegeneration\tB-Disease\nof\tI-Disease\ndopaminergic\tI-Disease\nneurons\tI-Disease\nin\tO\nrat\tO\nsubstantia\tO\nnigra\tO\n.\tO\n\nIron\tB-Chemical\naccumulation\tO\nis\tO\nconsidered\tO\nto\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nTo\tO\ndemonstrate\tO\nthe\tO\nrelationship\tO\nbetween\tO\nperipheral\tO\niron\tB-Chemical\noverload\tO\nand\tO\ndopaminergic\tO\nneuron\tO\nloss\tO\nin\tO\nrat\tO\nsubstantia\tO\nnigra\tO\n(\tO\nSN\tO\n)\tO\n,\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\nwe\tO\nused\tO\nfast\tO\ncyclic\tO\nvoltammetry\tO\n,\tO\ntyrosine\tB-Chemical\nhydroxylase\tO\n(\tO\nTH\tO\n)\tO\nimmunohistochemistry\tO\n,\tO\nPerls\tO\n'\tO\niron\tB-Chemical\nstaining\tO\n,\tO\nand\tO\nhigh\tO\nperformance\tO\nliquid\tO\nchromatography\tO\n-\tO\nelectrochemical\tO\ndetection\tO\nto\tO\nstudy\tO\nthe\tO\ndegeneration\tB-Disease\nof\tI-Disease\ndopaminergic\tI-Disease\nneurons\tI-Disease\nand\tO\nincreased\tO\niron\tB-Chemical\ncontent\tO\nin\tO\nthe\tO\nSN\tO\nof\tO\niron\tB-Chemical\ndextran\tI-Chemical\noverloaded\tO\nanimals\tO\n.\tO\n\nThe\tO\nfindings\tO\nshowed\tO\nthat\tO\nperipheral\tO\niron\tB-Chemical\ndextran\tI-Chemical\noverload\tO\nincreased\tO\nthe\tO\niron\tB-Chemical\nstaining\tO\npositive\tO\ncells\tO\nand\tO\nreduced\tO\nthe\tO\nnumber\tO\nof\tO\nTH\tO\n-\tO\nimmunoreactive\tO\nneurons\tO\nin\tO\nthe\tO\nSN\tO\n.\tO\n\nAs\tO\na\tO\nresult\tO\n,\tO\ndopamine\tB-Chemical\nrelease\tO\nand\tO\ncontent\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nits\tO\nmetabolites\tO\ncontents\tO\nwere\tO\ndecreased\tO\nin\tO\ncaudate\tO\nputamen\tO\n.\tO\n\nEven\tO\nmore\tO\ndramatic\tO\nchanges\tO\nwere\tO\nfound\tO\nin\tO\nchronic\tO\noverload\tO\ngroup\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nperipheral\tO\niron\tB-Chemical\ndextran\tI-Chemical\ncan\tO\nincrease\tO\nthe\tO\niron\tB-Chemical\nlevel\tO\nin\tO\nthe\tO\nSN\tO\n,\tO\nwhere\tO\nexcessive\tO\niron\tB-Chemical\ncauses\tO\nthe\tO\ndegeneration\tB-Disease\nof\tI-Disease\ndopaminergic\tI-Disease\nneurons\tI-Disease\n.\tO\n\nThe\tO\nchronic\tO\niron\tB-Chemical\noverload\tO\nmay\tO\nbe\tO\nmore\tO\ndestructive\tO\nto\tO\ndopaminergic\tO\nneurons\tO\nthan\tO\nthe\tO\nacute\tO\niron\tB-Chemical\noverload\tO\n.\tO\n\nAttenuated\tO\ndisruption\tO\nof\tO\nprepulse\tO\ninhibition\tO\nby\tO\ndopaminergic\tO\nstimulation\tO\nafter\tO\nmaternal\tO\ndeprivation\tO\nand\tO\nadolescent\tO\ncorticosterone\tB-Chemical\ntreatment\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nschizophrenia\tB-Disease\nmay\tO\ninclude\tO\nan\tO\nearly\tO\nneurodevelopmental\tO\nstress\tO\ncomponent\tO\nwhich\tO\nincreases\tO\nvulnerability\tO\nto\tO\nlater\tO\nstressful\tO\nlife\tO\nevents\tO\n,\tO\nin\tO\ncombination\tO\nleading\tO\nto\tO\novert\tO\ndisease\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\neffect\tO\nof\tO\nan\tO\nearly\tO\nstress\tO\n,\tO\nin\tO\nthe\tO\nform\tO\nof\tO\nmaternal\tO\ndeprivation\tO\n,\tO\ncombined\tO\nwith\tO\na\tO\nlater\tO\nstress\tO\n,\tO\nsimulated\tO\nby\tO\nchronic\tO\nperiadolescent\tO\ncorticosterone\tB-Chemical\ntreatment\tO\n,\tO\non\tO\nbehaviour\tO\nin\tO\nrats\tO\n.\tO\n\nAcute\tO\ntreatment\tO\nwith\tO\napomorphine\tB-Chemical\ncaused\tO\ndisruption\tO\nof\tO\nprepulse\tO\ninhibition\tO\n(\tO\nPPI\tO\n)\tO\nin\tO\ncontrols\tO\nand\tO\nin\tO\nrats\tO\nthat\tO\nhad\tO\nundergone\tO\neither\tO\nmaternal\tO\ndeprivation\tO\nor\tO\ncorticosterone\tB-Chemical\ntreatment\tO\n,\tO\nbut\tO\nwas\tO\nsurprisingly\tO\nabsent\tO\nin\tO\nrats\tO\nthat\tO\nhad\tO\nundergone\tO\nthe\tO\ncombined\tO\nearly\tO\nand\tO\nlate\tO\nstress\tO\n.\tO\n\nAmphetamine\tB-Chemical\ntreatment\tO\nsignificantly\tO\ndisrupted\tO\nPPI\tO\nin\tO\nboth\tO\nnon\tO\n-\tO\ndeprived\tO\ngroups\tO\n,\tO\nbut\tO\nwas\tO\nabsent\tO\nin\tO\nboth\tO\nmaternally\tO\ndeprived\tO\ngroups\tO\n.\tO\n\nThe\tO\nserotonin\tB-Chemical\n-\tO\n1A\tO\nreceptor\tO\nagonist\tO\n,\tO\n8\tB-Chemical\n-\tI-Chemical\nOH\tI-Chemical\n-\tI-Chemical\nDPAT\tI-Chemical\n,\tO\ninduced\tO\na\tO\nsignificant\tO\ndisruption\tO\nof\tO\nPPI\tO\nin\tO\nall\tO\ngroups\tO\n.\tO\n\nAmphetamine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\nwas\tO\nsimilar\tO\nin\tO\nall\tO\ngroups\tO\n.\tO\n\nThese\tO\nresults\tO\nshow\tO\nan\tO\ninhibitory\tO\ninteraction\tO\nof\tO\nearly\tO\nstress\tO\n,\tO\ncaused\tO\nby\tO\nmaternal\tO\ndeprivation\tO\n,\tO\ncombined\tO\nwith\tO\n'\tO\nadolescent\tO\n'\tO\nstress\tO\n,\tO\nsimulated\tO\nby\tO\ncorticosterone\tB-Chemical\ntreatment\tO\n,\tO\non\tO\ndopaminergic\tO\nregulation\tO\nof\tO\nPPI\tO\n.\tO\n\nThe\tO\naltered\tO\neffects\tO\nof\tO\napomorphine\tB-Chemical\nand\tO\namphetamine\tB-Chemical\ncould\tO\nindicate\tO\ndifferential\tO\nchanges\tO\nin\tO\ndopamine\tB-Chemical\nreceptor\tO\nsignalling\tO\nleading\tO\nto\tO\nfunctional\tO\ndesensitisation\tO\n,\tO\nor\tO\naltered\tO\nmodulation\tO\nof\tO\nsensory\tO\ngating\tO\nin\tO\nthe\tO\nnucleus\tO\naccumbens\tO\nby\tO\nlimbic\tO\nstructures\tO\nsuch\tO\nas\tO\nthe\tO\nhippocampus\tO\n.\tO\n\nAn\tO\nextremely\tO\nrare\tO\ncase\tO\nof\tO\ndelusional\tB-Disease\nparasitosis\tI-Disease\nin\tO\na\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nC\tI-Disease\npatient\tO\nduring\tO\npegylated\tB-Chemical\ninterferon\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\n2b\tI-Chemical\nand\tO\nribavirin\tB-Chemical\ntreatment\tO\n.\tO\n\nDuring\tO\ntreatment\tO\nof\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nC\tI-Disease\npatients\tO\nwith\tO\ninterferon\tO\nand\tO\nribavirin\tB-Chemical\n,\tO\na\tO\nlot\tO\nof\tO\nside\tO\neffects\tO\nare\tO\ndescribed\tO\n.\tO\n\nTwenty\tO\n-\tO\nthree\tO\npercent\tO\nto\tO\n44\tO\n%\tO\nof\tO\npatients\tO\ndevelop\tO\ndepression\tB-Disease\n.\tO\n\nA\tO\nminority\tO\nof\tO\npatients\tO\nevolve\tO\nto\tO\npsychosis\tB-Disease\n.\tO\n\nTo\tO\nthe\tO\nbest\tO\nof\tO\nour\tO\nknowledge\tO\n,\tO\nno\tO\ncases\tO\nof\tO\npsychogenic\tB-Disease\nparasitosis\tI-Disease\noccurring\tO\nduring\tO\ninterferon\tO\ntherapy\tO\nhave\tO\nbeen\tO\ndescribed\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\n49\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwho\tO\ndeveloped\tO\na\tO\ndelusional\tB-Disease\nparasitosis\tI-Disease\nduring\tO\ntreatment\tO\nwith\tO\npegylated\tB-Chemical\ninterferon\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\n2b\tI-Chemical\nweekly\tO\nand\tO\nribavirin\tB-Chemical\n.\tO\n\nShe\tO\ncomplained\tO\nof\tO\nseeing\tO\nparasites\tO\nand\tO\nthe\tO\nlarvae\tO\nof\tO\nfleas\tO\nin\tO\nher\tO\nstools\tO\n.\tO\n\nThis\tO\ncould\tO\nnot\tO\nbe\tO\nconfirmed\tO\nby\tO\nany\tO\ntechnical\tO\nexamination\tO\n.\tO\n\nAll\tO\nthe\tO\ncomplaints\tO\ndisappeared\tO\nafter\tO\nstopping\tO\npegylated\tB-Chemical\ninterferon\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\n2b\tI-Chemical\nand\tO\nreappeared\tO\nafter\tO\nrestarting\tO\nit\tO\n.\tO\n\nShe\tO\nhad\tO\na\tO\ncomplete\tO\nsustained\tO\nviral\tO\nresponse\tO\n.\tO\n\nHepatonecrosis\tB-Disease\nand\tO\ncholangitis\tB-Disease\nrelated\tO\nto\tO\nlong\tO\n-\tO\nterm\tO\nphenobarbital\tB-Chemical\ntherapy\tO\n:\tO\nan\tO\nautopsy\tO\nreport\tO\nof\tO\ntwo\tO\npatients\tO\n.\tO\n\nPhenobarbital\tB-Chemical\n(\tO\nPB\tB-Chemical\n)\tO\nhas\tO\na\tO\nreputation\tO\nfor\tO\nsafety\tO\n,\tO\nand\tO\nit\tO\nis\tO\ncommonly\tO\nbelieved\tO\nthat\tO\nPB\tB-Chemical\n-\tO\nrelated\tO\nincreases\tO\nin\tO\nserum\tO\naminotransferase\tO\nlevels\tO\ndo\tO\nnot\tO\nindicate\tO\nor\tO\npredict\tO\nthe\tO\ndevelopment\tO\nof\tO\nsignificant\tO\nchronic\tO\nliver\tB-Disease\ndisease\tI-Disease\n.\tO\n\nHere\tO\nwe\tO\nreport\tO\nof\tO\ntwo\tO\nadult\tO\npatients\tO\nwith\tO\na\tO\nlong\tO\nhistory\tO\nof\tO\nepilepsy\tB-Disease\ntreated\tO\nwith\tO\nPB\tB-Chemical\nwho\tO\ndied\tO\nsuddenly\tO\n:\tO\none\tO\nas\tO\nconsequence\tO\nof\tO\ncardiac\tB-Disease\narrest\tI-Disease\n,\tO\nthe\tO\nother\tO\nof\tO\nacute\tO\nbronchopneumonia\tB-Disease\n.\tO\n\nAt\tO\nautopsy\tO\n,\tO\nanalysis\tO\nof\tO\nliver\tO\nparenchyma\tO\nrevealed\tO\nrich\tO\nportal\tO\ninflammatory\tO\ninfiltrate\tO\n,\tO\nwhich\tO\nconsisted\tO\nof\tO\nmixed\tO\neosinophil\tO\nand\tO\nmonocyte\tO\ncells\tO\n,\tO\nassociated\tO\nwith\tO\nseveral\tO\nfoci\tO\nof\tO\nnecrosis\tB-Disease\nsurrounded\tO\nby\tO\na\tO\nhard\tO\nring\tO\nof\tO\nnon\tO\n-\tO\nspecific\tO\ngranulomatous\tO\ntissue\tO\n.\tO\n\nInflammatory\tO\nreactions\tO\nof\tO\ninternal\tO\nand\tO\nexternal\tO\nhepatic\tO\nbiliary\tO\nducts\tO\nwere\tO\nalso\tO\nseen\tO\n.\tO\n\nOur\tO\nfindings\tO\nillustrate\tO\nthat\tO\nPB\tB-Chemical\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nchronic\tO\nliver\tB-Disease\ndamage\tI-Disease\n,\tO\nwhich\tO\nmay\tO\nlead\tO\nto\tO\nmore\tO\nserious\tO\nand\tO\ndeleterious\tO\nconsequences\tO\n.\tO\n\nFor\tO\nthis\tO\nreason\tO\n,\tO\neach\tO\nclinician\tO\nshould\tO\nrecognize\tO\nthis\tO\nentity\tO\nin\tO\nthe\tO\ndifferential\tO\ndiagnosis\tO\nof\tO\nPB\tB-Chemical\n-\tO\nrelated\tO\nasymptomatic\tO\nchronic\tB-Disease\nhepatic\tI-Disease\nenzyme\tI-Disease\ndysfunction\tI-Disease\n.\tO\n\nDelayed\tO\nleukoencephalopathy\tB-Disease\nwith\tO\nstroke\tB-Disease\n-\tO\nlike\tO\npresentation\tO\nin\tO\nchemotherapy\tO\nrecipients\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nA\tO\ntransient\tO\nleukoencephalopathy\tB-Disease\nmimicking\tO\ncerebrovascular\tB-Disease\naccident\tI-Disease\nhas\tO\nbeen\tO\ndescribed\tO\nas\tO\na\tO\ncomplication\tO\nof\tO\nchemotherapy\tO\n,\tO\nmost\tO\ncommonly\tO\nin\tO\nrecipients\tO\nof\tO\nintrathecal\tO\nmethotrexate\tB-Chemical\nfor\tO\nchildhood\tO\nleukaemia\tB-Disease\n.\tO\n\nRecently\tO\npublished\tO\nneuroimaging\tO\ndata\tO\nsuggest\tO\na\tO\ncommon\tO\npathophysiology\tO\nassociated\tO\nwith\tO\na\tO\nvariety\tO\nof\tO\nchemotherapy\tO\nagents\tO\nand\tO\nmodes\tO\nof\tO\nadministration\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nreviewed\tO\nthe\tO\nmedical\tO\nliterature\tO\nfor\tO\nsingle\tO\nreports\tO\nand\tO\ncase\tO\nseries\tO\nof\tO\npatients\tO\npresenting\tO\nwith\tO\nstroke\tB-Disease\n-\tO\nlike\tO\nepisodes\tO\nwhile\tO\nreceiving\tO\nsystemic\tO\nor\tO\nintrathecal\tO\nchemotherapy\tO\n.\tO\n\nWe\tO\nonly\tO\nincluded\tO\nstudies\tO\nproviding\tO\ndetailed\tO\nneuroimaging\tO\ndata\tO\n.\tO\n\nPatients\tO\nwith\tO\ncerebrovascular\tB-Disease\naccidents\tI-Disease\nwere\tO\nexcluded\tO\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nidentified\tO\n27\tO\nreports\tO\nof\tO\ntoxic\tO\nleukoencephalopathy\tB-Disease\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nmethotrexate\tB-Chemical\n(\tO\nintrathecal\tO\n,\tO\nsystemic\tO\n)\tO\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\nand\tO\nits\tO\nderivative\tO\ncarmofur\tB-Chemical\n,\tO\nand\tO\ncapecitabine\tB-Chemical\n.\tO\n\nDiffusion\tO\nweighted\tO\nimaging\tO\n(\tO\nDWI\tO\n)\tO\nof\tO\nall\tO\npatients\tO\nrevealed\tO\nwell\tO\ndemarcated\tO\nhyperintense\tO\nlesions\tB-Disease\nwithin\tI-Disease\nthe\tI-Disease\nsubcortical\tI-Disease\nwhite\tI-Disease\nmatter\tI-Disease\nof\tO\nthe\tO\ncerebral\tO\nhemispheres\tO\nand\tO\nthe\tO\ncorpus\tO\ncallosum\tO\n,\tO\ncorresponding\tO\nto\tO\nareas\tO\nof\tO\ndecreased\tO\nproton\tO\ndiffusion\tO\non\tO\napparent\tO\ndiffusion\tO\ncoefficient\tO\n(\tO\nADC\tO\n)\tO\nmaps\tO\n(\tO\navailable\tO\nin\tO\n21\tO\n/\tO\n27\tO\npatients\tO\n)\tO\n.\tO\n\nLesions\tO\nexceeded\tO\nthe\tO\nconfines\tO\nof\tO\nadjacent\tO\nvascular\tO\nterritories\tO\n.\tO\n\nComplete\tO\nresolution\tO\nof\tO\nsymptoms\tO\nwithin\tO\n1\tO\n-\tO\n4\tO\ndays\tO\nwas\tO\naccompanied\tO\nby\tO\nnormalisation\tO\nof\tO\nADC\tO\nabnormalities\tO\n.\tO\n\nHowever\tO\n,\tO\nfluid\tO\nattenuated\tO\ninversion\tO\nrecovery\tO\n(\tO\nFLAIR\tO\n)\tO\nsequences\tO\nfrequently\tO\nrevealed\tO\npersistent\tO\nwhite\tB-Disease\nmatter\tI-Disease\nabnormalities\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSeveral\tO\npathophysiological\tO\nmodels\tO\nof\tO\ndelayed\tO\nleukoencephalopathy\tB-Disease\nafter\tO\nexposure\tO\nto\tO\nintrathecal\tO\nor\tO\nsystemic\tO\nchemotherapy\tO\nhave\tO\nbeen\tO\nproposed\tO\n.\tO\n\nDWI\tO\nfindings\tO\nin\tO\nthis\tO\ncohort\tO\nare\tO\nindicative\tO\nof\tO\ncytotoxic\tB-Disease\noedema\tI-Disease\nwithin\tI-Disease\ncerebral\tI-Disease\nwhite\tI-Disease\nmatter\tI-Disease\nand\tO\nlend\tO\nsupport\tO\nto\tO\nan\tO\nat\tO\nleast\tO\npartially\tO\nreversible\tO\nmetabolic\tO\nderangement\tO\nas\tO\nthe\tO\nbasis\tO\nfor\tO\nthis\tO\nsyndrome\tO\n.\tO\n\nPrenatal\tO\nexposure\tO\nto\tO\nfluoxetine\tB-Chemical\ninduces\tO\nfetal\tB-Disease\npulmonary\tI-Disease\nhypertension\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nRATIONALE\tO\n:\tO\nFluoxetine\tB-Chemical\nis\tO\na\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitor\tO\nantidepressant\tO\nwidely\tO\nused\tO\nby\tO\npregnant\tO\nwomen\tO\n.\tO\n\nEpidemiological\tO\ndata\tO\nsuggest\tO\nthat\tO\nfluoxetine\tB-Chemical\nexposure\tO\nprenatally\tO\nincreases\tO\nthe\tO\nprevalence\tO\nof\tO\npersistent\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nsyndrome\tI-Disease\nof\tO\nthe\tO\nnewborn\tO\n.\tO\n\nThe\tO\nmechanism\tO\nresponsible\tO\nfor\tO\nthis\tO\neffect\tO\nis\tO\nunclear\tO\nand\tO\nparadoxical\tO\n,\tO\nconsidering\tO\nthe\tO\ncurrent\tO\nevidence\tO\nof\tO\na\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nprotective\tO\nfluoxetine\tB-Chemical\neffect\tO\nin\tO\nadult\tO\nrodents\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nfluoxetine\tB-Chemical\neffect\tO\non\tO\nfetal\tO\nrat\tO\npulmonary\tO\nvascular\tO\nsmooth\tO\nmuscle\tO\nmechanical\tO\nproperties\tO\nand\tO\ncell\tO\nproliferation\tO\nrate\tO\n.\tO\n\nMETHODS\tO\n:\tO\nPregnant\tO\nrats\tO\nwere\tO\ntreated\tO\nwith\tO\nfluoxetine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nfrom\tO\nDay\tO\n11\tO\nthrough\tO\nDay\tO\n21\tO\nof\tO\ngestation\tO\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nFetuses\tO\nwere\tO\ndelivered\tO\nby\tO\ncesarean\tO\nsection\tO\n.\tO\n\nAs\tO\ncompared\tO\nwith\tO\ncontrols\tO\n,\tO\nfluoxetine\tB-Chemical\nexposure\tO\nresulted\tO\nin\tO\nfetal\tB-Disease\npulmonary\tI-Disease\nhypertension\tI-Disease\nas\tO\nevidenced\tO\nby\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\nweight\tO\nratio\tO\nof\tO\nthe\tO\nright\tO\nventricle\tO\nto\tO\nthe\tO\nleft\tO\nventricle\tO\nplus\tO\nseptum\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n02\tO\n)\tO\nand\tO\nby\tO\nan\tO\nincrease\tO\nin\tO\npulmonary\tO\narterial\tO\nmedial\tO\nthickness\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nPostnatal\tO\nmortality\tO\nwas\tO\nincreased\tO\namong\tO\nexperimental\tO\nanimals\tO\n,\tO\nand\tO\narterial\tO\noxygen\tB-Chemical\nsaturation\tO\nwas\tO\n96\tO\n+\tO\n/\tO\n-\tO\n1\tO\n%\tO\nin\tO\n1\tO\n-\tO\nday\tO\n-\tO\nold\tO\ncontrol\tO\nanimals\tO\nand\tO\nsignificantly\tO\nlower\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nin\tO\nfluoxetine\tB-Chemical\n-\tO\nexposed\tO\npups\tO\n(\tO\n79\tO\n+\tO\n/\tO\n-\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nIn\tO\nvitro\tO\n,\tO\nfluoxetine\tB-Chemical\ninduced\tO\npulmonary\tO\narterial\tO\nmuscle\tO\ncontraction\tO\nin\tO\nfetal\tO\n,\tO\nbut\tO\nnot\tO\nadult\tO\n,\tO\nanimals\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nand\tO\nreduced\tO\nserotonin\tB-Chemical\n-\tO\ninduced\tO\ncontraction\tO\nat\tO\nboth\tO\nages\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nAfter\tO\nin\tO\nutero\tO\nexposure\tO\nto\tO\na\tO\nlow\tO\nfluoxetine\tB-Chemical\nconcentration\tO\nthe\tO\npulmonary\tO\narterial\tO\nsmooth\tO\nmuscle\tO\ncell\tO\nproliferation\tO\nrate\tO\nwas\tO\nsignificantly\tO\nincreased\tO\nin\tO\nfetal\tO\n,\tO\nbut\tO\nnot\tO\nadult\tO\n,\tO\ncells\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\ncontrast\tO\nto\tO\nthe\tO\nadult\tO\n,\tO\nfluoxetine\tB-Chemical\nexposure\tO\nin\tO\nutero\tO\ninduces\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nin\tO\nthe\tO\nfetal\tO\nrat\tO\nas\tO\na\tO\nresult\tO\nof\tO\na\tO\ndevelopmentally\tO\nregulated\tO\nincrease\tO\nin\tO\npulmonary\tO\nvascular\tO\nsmooth\tO\nmuscle\tO\nproliferation\tO\n.\tO\n\nDisulfiram\tB-Chemical\n-\tO\ninduced\tO\ntransient\tO\noptic\tB-Disease\nand\tI-Disease\nperipheral\tI-Disease\nneuropathy\tI-Disease\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nAIM\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\noptic\tB-Disease\nand\tI-Disease\nperipheral\tI-Disease\nneuropathy\tI-Disease\nafter\tO\nchronic\tO\nuse\tO\nof\tO\ndisulfiram\tB-Chemical\nfor\tO\nalcohol\tB-Disease\ndependence\tI-Disease\nmanagement\tO\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nA\tO\ncase\tO\nreport\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\n57\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\npresented\tO\nwith\tO\ngradual\tO\nloss\tB-Disease\nof\tI-Disease\nvision\tI-Disease\nin\tO\nboth\tO\neyes\tO\nwith\tO\nintermittent\tO\nheadaches\tB-Disease\nfor\tO\n2\tO\nmonths\tO\n.\tO\n\nHe\tO\nalso\tO\ncomplained\tO\nof\tO\nparaesthesia\tB-Disease\nwith\tO\nnumbness\tB-Disease\nin\tO\nboth\tO\nfeet\tO\n.\tO\n\nHis\tO\nvision\tO\nwas\tO\n6\tO\n/\tO\n15\tO\nand\tO\n2\tO\n/\tO\n60\tO\nin\tO\nthe\tO\nright\tO\nand\tO\nleft\tO\neyes\tO\n,\tO\nrespectively\tO\n.\tO\n\nFundoscopy\tO\nrevealed\tO\nbilaterally\tO\nswollen\tO\noptic\tO\nnerve\tO\nheads\tO\n.\tO\n\nVisual\tO\nfield\tO\ntesting\tO\nconfirmed\tO\nbilateral\tO\ncentral\tO\n-\tO\ncaecal\tO\nscotomata\tB-Disease\n.\tO\n\nHe\tO\nhad\tO\nbeen\tO\ntaking\tO\ndisulfiram\tB-Chemical\nfor\tO\nalcohol\tB-Disease\ndependence\tI-Disease\nfor\tO\nthe\tO\npreceding\tO\n3\tO\nyears\tO\n.\tO\n\nDisulfiram\tB-Chemical\ndiscontinuation\tO\nlead\tO\nto\tO\nan\tO\nimmediate\tO\nsymptomatic\tO\nimprovement\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nPhysicians\tO\ninitiating\tO\nlong\tO\n-\tO\nterm\tO\ndisulfiram\tB-Chemical\ntherapy\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthese\tO\nadverse\tO\neffects\tO\n.\tO\n\nThey\tO\nshould\tO\nrecommend\tO\nannual\tO\nophthalmic\tO\nreviews\tO\nwith\tO\nvisual\tO\nfield\tO\ntesting\tO\n.\tO\n\nPatients\tO\nshould\tO\nbe\tO\nreassured\tO\nwith\tO\nrespect\tO\nto\tO\nthe\tO\nreversibility\tO\nof\tO\nthese\tO\nadverse\tO\neffects\tO\n.\tO\n\nIntraocular\tO\npressure\tO\nin\tO\npatients\tO\nwith\tO\nuveitis\tB-Disease\ntreated\tO\nwith\tO\nfluocinolone\tB-Chemical\nacetonide\tI-Chemical\nimplants\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\nthe\tO\nincidence\tO\nand\tO\nmanagement\tO\nof\tO\nelevated\tB-Disease\nintraocular\tI-Disease\npressure\tI-Disease\n(\tO\nIOP\tO\n)\tO\nin\tO\npatients\tO\nwith\tO\nuveitis\tB-Disease\ntreated\tO\nwith\tO\nthe\tO\nfluocinolone\tB-Chemical\nacetonide\tI-Chemical\n(\tO\nFA\tB-Chemical\n)\tO\nintravitreal\tO\nimplant\tO\n.\tO\n\nDESIGN\tO\n:\tO\nPooled\tO\ndata\tO\nfrom\tO\n3\tO\nmulticenter\tO\n,\tO\ndouble\tO\n-\tO\nmasked\tO\n,\tO\nrandomized\tO\n,\tO\ncontrolled\tO\n,\tO\nphase\tO\n2b\tO\n/\tO\n3\tO\nclinical\tO\ntrials\tO\nevaluating\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nthe\tO\n0\tO\n.\tO\n59\tO\n-\tO\nmg\tO\nor\tO\n2\tO\n.\tO\n1\tO\n-\tO\nmg\tO\nFA\tB-Chemical\nintravitreal\tO\nimplant\tO\nor\tO\nstandard\tO\ntherapy\tO\nwere\tO\nanalyzed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nDuring\tO\nthe\tO\n3\tO\n-\tO\nyear\tO\nfollow\tO\n-\tO\nup\tO\n,\tO\n71\tO\n.\tO\n0\tO\n%\tO\nof\tO\nimplanted\tO\neyes\tO\nhad\tO\nan\tO\nIOP\tO\nincrease\tO\nof\tO\n10\tO\nmm\tO\nHg\tO\nor\tO\nmore\tO\nthan\tO\nbaseline\tO\nand\tO\n55\tO\n.\tO\n1\tO\n%\tO\n,\tO\n24\tO\n.\tO\n7\tO\n%\tO\n,\tO\nand\tO\n6\tO\n.\tO\n2\tO\n%\tO\nof\tO\neyes\tO\nreached\tO\nan\tO\nIOP\tO\nof\tO\n30\tO\nmm\tO\nHg\tO\nor\tO\nmore\tO\n,\tO\n40\tO\nmm\tO\nHg\tO\nor\tO\nmore\tO\n,\tO\nand\tO\n50\tO\nmm\tO\nHg\tO\nor\tO\nmore\tO\n,\tO\nrespectively\tO\n.\tO\n\nTopical\tO\nIOP\tO\n-\tO\nlowering\tO\nmedication\tO\nwas\tO\nadministered\tO\nin\tO\n74\tO\n.\tO\n8\tO\n%\tO\nof\tO\nimplanted\tO\neyes\tO\n,\tO\nand\tO\nIOP\tO\n-\tO\nlowering\tO\nsurgeries\tO\n,\tO\nmost\tO\nof\tO\nwhich\tO\nwere\tO\ntrabeculectomies\tO\n(\tO\n76\tO\n.\tO\n2\tO\n%\tO\n)\tO\n,\tO\nwere\tO\nperformed\tO\non\tO\n36\tO\n.\tO\n6\tO\n%\tO\nof\tO\nimplanted\tO\neyes\tO\n.\tO\n\nIntraocular\tO\npressure\tO\n-\tO\nlowering\tO\nsurgeries\tO\nwere\tO\nconsidered\tO\na\tO\nsuccess\tO\n(\tO\npostoperative\tO\nIOP\tO\nof\tO\n6\tO\n-\tO\n21\tO\nmm\tO\nHg\tO\nwith\tO\nor\tO\nwithout\tO\nadditional\tO\nIOP\tO\n-\tO\nlowering\tO\nmedication\tO\n)\tO\nin\tO\n85\tO\n.\tO\n1\tO\n%\tO\nof\tO\neyes\tO\nat\tO\n1\tO\nyear\tO\n.\tO\n\nThe\tO\nrate\tO\nof\tO\nhypotony\tB-Disease\n(\tO\nIOP\tO\n<\tO\n/\tO\n=\tO\n5\tO\nmm\tO\nHg\tO\n)\tO\nfollowing\tO\nIOP\tO\n-\tO\nlowering\tO\nsurgery\tO\n(\tO\n42\tO\n.\tO\n5\tO\n%\tO\n)\tO\nwas\tO\nnot\tO\ndifferent\tO\nfrom\tO\nthat\tO\nof\tO\nimplanted\tO\neyes\tO\nnot\tO\nsubjected\tO\nto\tO\nsurgery\tO\n(\tO\n35\tO\n.\tO\n4\tO\n%\tO\n)\tO\n(\tO\nP\tO\n=\tO\n.\tO\n09\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nElevated\tO\nIOP\tO\nis\tO\na\tO\nsignificant\tO\ncomplication\tO\nwith\tO\nthe\tO\nFA\tO\nintravitreal\tO\nimplant\tO\nbut\tO\nmay\tO\nbe\tO\ncontrolled\tO\nwith\tO\nmedication\tO\nand\tO\nsurgery\tO\n.\tO\n\nMyocardial\tO\nFas\tO\nligand\tO\nexpression\tO\nincreases\tO\nsusceptibility\tO\nto\tO\nAZT\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nDilated\tB-Disease\ncardiomyopathy\tI-Disease\n(\tO\nDCM\tB-Disease\n)\tO\nand\tO\nmyocarditis\tB-Disease\noccur\tO\nin\tO\nmany\tO\nHIV\tB-Disease\n-\tI-Disease\ninfected\tI-Disease\nindividuals\tO\n,\tO\nresulting\tO\nin\tO\nsymptomatic\tO\nheart\tB-Disease\nfailure\tI-Disease\nin\tO\nup\tO\nto\tO\n5\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nHighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nhas\tO\nsignificantly\tO\nreduced\tO\nmorbidity\tO\nand\tO\nmortality\tO\nof\tO\nacquired\tB-Disease\nimmunodeficiency\tI-Disease\nsyndrome\tI-Disease\n(\tO\nAIDS\tB-Disease\n)\tO\n,\tO\nbut\tO\nhas\tO\nresulted\tO\nin\tO\nan\tO\nincrease\tO\nin\tO\ncardiac\tB-Disease\nand\tI-Disease\nskeletal\tI-Disease\nmyopathies\tI-Disease\n.\tO\n\nMETHODS\tO\nAND\tO\nRESULTS\tO\n:\tO\nIn\tO\norder\tO\nto\tO\ninvestigate\tO\nwhether\tO\nthe\tO\nHAART\tO\ncomponent\tO\nzidovudine\tB-Chemical\n(\tO\n3\tB-Chemical\n'\tI-Chemical\n-\tI-Chemical\nazido\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n'\tI-Chemical\n,\tI-Chemical\n3\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\ndeoxythymidine\tI-Chemical\n;\tO\nAZT\tB-Chemical\n)\tO\ntriggers\tO\nthe\tO\nFas\tO\n-\tO\ndependent\tO\ncell\tO\n-\tO\ndeath\tO\npathway\tO\nand\tO\ncause\tO\ncytoskeletal\tO\ndisruption\tO\nin\tO\na\tO\nmurine\tO\nmodel\tO\nof\tO\nDCM\tB-Disease\n,\tO\n8\tO\n-\tO\nweek\tO\n-\tO\nold\tO\ntransgenic\tO\n(\tO\nexpressing\tO\nFas\tO\nligand\tO\nin\tO\nthe\tO\nmyocardium\tO\n:\tO\nFasL\tO\nTg\tO\n)\tO\nand\tO\nnon\tO\n-\tO\ntransgenic\tO\n(\tO\nNTg\tO\n)\tO\nmice\tO\nreceived\tO\nwater\tO\nad\tO\nlibitum\tO\ncontaining\tO\ndifferent\tO\nconcentrations\tO\nof\tO\nAZT\tB-Chemical\n(\tO\n0\tO\n,\tO\n0\tO\n.\tO\n07\tO\n,\tO\n0\tO\n.\tO\n2\tO\n,\tO\nand\tO\n0\tO\n.\tO\n7\tO\nmg\tO\n/\tO\nml\tO\n)\tO\n.\tO\n\nAfter\tO\n6\tO\nweeks\tO\n,\tO\ncardiac\tO\nfunction\tO\nwas\tO\nassessed\tO\nby\tO\nechocardiography\tO\nand\tO\nmorphology\tO\nwas\tO\nassessed\tO\nby\tO\nhistopathologic\tO\nand\tO\nimmunohistochemical\tO\nmethods\tO\n.\tO\n\nNTg\tO\nand\tO\nuntreated\tO\nFasL\tO\nTg\tO\nmice\tO\nshowed\tO\nlittle\tO\nor\tO\nno\tO\nchange\tO\nin\tO\ncardiac\tO\nstructure\tO\nor\tO\nfunction\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nAZT\tB-Chemical\n-\tO\ntreated\tO\nFasL\tO\nTg\tO\nmice\tO\ndeveloped\tO\ncardiac\tB-Disease\ndilation\tI-Disease\nand\tO\ndepressed\tO\ncardiac\tO\nfunction\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n,\tO\nwith\tO\nconcomitant\tO\ninflammatory\tO\ninfiltration\tO\nof\tO\nboth\tO\nventricles\tO\n.\tO\n\nThese\tO\nchanges\tO\nwere\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nsarcolemmal\tO\nexpression\tO\nof\tO\nFas\tO\nand\tO\nFasL\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nincreased\tO\nactivation\tO\nof\tO\ncaspase\tO\n3\tO\n,\tO\ntranslocation\tO\nof\tO\ncalpain\tO\n1\tO\nto\tO\nthe\tO\nsarcolemma\tO\nand\tO\nsarcomere\tO\n,\tO\nand\tO\nincreased\tO\nnumbers\tO\nof\tO\ncells\tO\nundergoing\tO\napoptosis\tO\n.\tO\n\nThese\tO\nwere\tO\nassociated\tO\nwith\tO\nchanges\tO\nin\tO\ndystrophin\tO\nand\tO\ncardiac\tO\ntroponin\tO\nI\tO\nlocalization\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nloss\tO\nof\tO\nsarcolemmal\tO\nintegrity\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nexpression\tO\nof\tO\nFas\tO\nligand\tO\nin\tO\nthe\tO\nmyocardium\tO\n,\tO\nas\tO\nidentified\tO\nin\tO\nHIV\tO\n-\tO\npositive\tO\npatients\tO\n,\tO\nmight\tO\nincrease\tO\nthe\tO\nsusceptibility\tO\nto\tO\nHAART\tO\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\ndue\tO\nto\tO\nactivation\tO\nof\tO\napoptotic\tO\npathways\tO\n,\tO\nresulting\tO\nin\tO\ncardiac\tB-Disease\ndilation\tI-Disease\nand\tI-Disease\ndysfunction\tI-Disease\n.\tO\n\nGastrointestinal\tO\ntolerability\tO\nof\tO\netoricoxib\tB-Chemical\nin\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\npatients\tO\n:\tO\nresults\tO\nof\tO\nthe\tO\netoricoxib\tB-Chemical\nvs\tO\ndiclofenac\tB-Chemical\nsodium\tI-Chemical\ngastrointestinal\tO\ntolerability\tO\nand\tO\neffectiveness\tO\ntrial\tO\n(\tO\nEDGE\tO\n-\tO\nII\tO\n)\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nA\tO\nrandomised\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\nto\tO\ncompare\tO\nthe\tO\ngastrointestinal\tO\n(\tO\nGI\tO\n)\tO\ntolerability\tO\n,\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\netoricoxib\tB-Chemical\nand\tO\ndiclofenac\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n(\tO\nRA\tB-Disease\n)\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n4086\tO\npatients\tO\n(\tO\nmean\tO\nage\tO\n60\tO\n.\tO\n8\tO\nyears\tO\n)\tO\ndiagnosed\tO\nwith\tO\nRA\tB-Disease\nwere\tO\nenrolled\tO\nand\tO\nreceived\tO\netoricoxib\tB-Chemical\n90\tO\nmg\tO\ndaily\tO\n(\tO\nn\tO\n=\tO\n2032\tO\n)\tO\nor\tO\ndiclofenac\tB-Chemical\n75\tO\nmg\tO\ntwice\tO\ndaily\tO\n(\tO\nn\tO\n=\tO\n2054\tO\n)\tO\n.\tO\n\nUse\tO\nof\tO\ngastroprotective\tO\nagents\tO\nand\tO\nlow\tO\n-\tO\ndose\tO\naspirin\tB-Chemical\nwas\tO\nallowed\tO\n.\tO\n\nThe\tO\nprespecified\tO\nprimary\tO\nend\tO\npoint\tO\nconsisted\tO\nof\tO\nthe\tO\ncumulative\tO\nrate\tO\nof\tO\npatient\tO\ndiscontinuations\tO\ndue\tO\nto\tO\nclinical\tO\nand\tO\nlaboratory\tO\nGI\tO\nadverse\tO\nexperiences\tO\n(\tO\nAEs\tO\n)\tO\n.\tO\n\nGeneral\tO\nsafety\tO\nwas\tO\nalso\tO\nassessed\tO\n,\tO\nincluding\tO\nadjudicated\tO\nthrombotic\tB-Disease\ncardiovascular\tI-Disease\nevent\tO\ndata\tO\n.\tO\n\nEfficacy\tO\nwas\tO\nevaluated\tO\nusing\tO\nthe\tO\nPatient\tO\nGlobal\tO\nAssessment\tO\nof\tO\nDisease\tO\nStatus\tO\n(\tO\nPGADS\tO\n;\tO\n0\tO\n-\tO\n4\tO\npoint\tO\nscale\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nMean\tO\n(\tO\nSD\tO\n;\tO\nmaximum\tO\n)\tO\nduration\tO\nof\tO\ntreatment\tO\nwas\tO\n19\tO\n.\tO\n3\tO\n(\tO\n10\tO\n.\tO\n3\tO\n;\tO\n32\tO\n.\tO\n9\tO\n)\tO\nand\tO\n19\tO\n.\tO\n1\tO\n(\tO\n10\tO\n.\tO\n4\tO\n;\tO\n33\tO\n.\tO\n1\tO\n)\tO\nmonths\tO\nin\tO\nthe\tO\netoricoxib\tB-Chemical\nand\tO\ndiclofenac\tB-Chemical\ngroups\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\ncumulative\tO\ndiscontinuation\tO\nrate\tO\ndue\tO\nto\tO\nGI\tB-Disease\nAEs\tI-Disease\nwas\tO\nsignificantly\tO\nlower\tO\nwith\tO\netoricoxib\tB-Chemical\nthan\tO\ndiclofenac\tB-Chemical\n(\tO\n5\tO\n.\tO\n2\tO\nvs\tO\n8\tO\n.\tO\n5\tO\nevents\tO\nper\tO\n100\tO\npatient\tO\n-\tO\nyears\tO\n,\tO\nrespectively\tO\n;\tO\nhazard\tO\nratio\tO\n0\tO\n.\tO\n62\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n47\tO\n,\tO\n0\tO\n.\tO\n81\tO\n;\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n)\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ndiscontinuations\tO\nfor\tO\nhypertension\tB-Disease\n-\tO\nrelated\tO\nand\tO\noedema\tB-Disease\n-\tO\nrelated\tO\nAEs\tO\nwere\tO\nsignificantly\tO\nhigher\tO\nwith\tO\netoricoxib\tB-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\n%\tO\nand\tO\n1\tO\n.\tO\n1\tO\n%\tO\nrespectively\tO\n)\tO\ncompared\tO\nwith\tO\ndiclofenac\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\n%\tO\nand\tO\n0\tO\n.\tO\n4\tO\n%\tO\nrespectively\tO\n;\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\nfor\tO\nhypertension\tB-Disease\nand\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\nfor\tO\noedema\tB-Disease\n)\tO\n.\tO\n\nEtoricoxib\tB-Chemical\nand\tO\ndiclofenac\tB-Chemical\ntreatment\tO\nresulted\tO\nin\tO\nsimilar\tO\nefficacy\tO\n(\tO\nPGADS\tO\nmean\tO\nchanges\tO\nfrom\tO\nbaseline\tO\n-\tO\n0\tO\n.\tO\n62\tO\nvs\tO\n-\tO\n0\tO\n.\tO\n58\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nEtoricoxib\tB-Chemical\n90\tO\nmg\tO\ndemonstrated\tO\na\tO\nsignificantly\tO\nlower\tO\nrisk\tO\nfor\tO\ndiscontinuing\tO\ntreatment\tO\ndue\tO\nto\tO\nGI\tB-Disease\nAEs\tI-Disease\ncompared\tO\nwith\tO\ndiclofenac\tB-Chemical\n150\tO\nmg\tO\n.\tO\n\nDiscontinuations\tO\nfrom\tO\nrenovascular\tO\nAEs\tO\n,\tO\nalthough\tO\nless\tO\ncommon\tO\nthan\tO\ndiscontinuations\tO\nfrom\tO\nGI\tB-Disease\nAEs\tI-Disease\n,\tO\nwere\tO\nsignificantly\tO\nhigher\tO\nwith\tO\netoricoxib\tB-Chemical\n.\tO\n\nAnxiogenic\tO\npotential\tO\nof\tO\nciprofloxacin\tB-Chemical\nand\tO\nnorfloxacin\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nINTRODUCTION\tO\n:\tO\nThe\tO\npossible\tO\nanxiogenic\tO\neffects\tO\nof\tO\nfluoroquinolones\tB-Chemical\n,\tO\nnamely\tO\nciprofloxacin\tB-Chemical\nand\tO\nnorfloxacin\tB-Chemical\n,\tO\nwere\tO\ninvestigated\tO\nin\tO\nadult\tO\nCharles\tO\nFoster\tO\nalbino\tO\nrats\tO\nof\tO\neither\tO\nsex\tO\n,\tO\nweighing\tO\n150\tO\n-\tO\n200\tO\ng\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\ndrugs\tO\nwere\tO\ngiven\tO\norally\tO\n,\tO\nin\tO\ndoses\tO\nof\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nfor\tO\nfive\tO\nconsecutive\tO\ndays\tO\nand\tO\nthe\tO\nexperiments\tO\nwere\tO\nperformed\tO\non\tO\nthe\tO\nfifth\tO\nday\tO\n.\tO\n\nThe\tO\ntests\tO\nincluded\tO\nopen\tO\n-\tO\nfield\tO\nexploratory\tO\nbehaviour\tO\n,\tO\nelevated\tO\nplus\tO\nmaze\tO\nand\tO\nelevated\tO\nzero\tO\nmaze\tO\n,\tO\nsocial\tO\ninteraction\tO\nand\tO\nnovelty\tO\n-\tO\nsuppressed\tO\nfeeding\tO\nlatency\tO\nbehaviour\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nciprofloxacin\tB-Chemical\n-\tO\nand\tO\nnorfloxacin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nshowed\tO\nanxious\tB-Disease\nbehaviour\tI-Disease\nin\tO\ncomparison\tO\nto\tO\ncontrol\tO\nrats\tO\nin\tO\nall\tO\nthe\tO\nparameters\tO\nstudied\tO\n.\tO\n\nHowever\tO\n,\tO\nciprofloxacin\tB-Chemical\n-\tO\nand\tO\nnorfloxacin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\ndid\tO\nnot\tO\ndiffer\tO\nsignificantly\tO\nfrom\tO\neach\tO\nother\tO\nin\tO\nvarious\tO\nbehavioural\tO\nparameters\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\npresent\tO\nexperimental\tO\nfindings\tO\nsubstantiate\tO\nthe\tO\nclinically\tO\nobserved\tO\nanxiogenic\tO\npotential\tO\nof\tO\nciprofloxacin\tB-Chemical\nand\tO\nnorfloxacin\tB-Chemical\n.\tO\n\nReduction\tO\nof\tO\npain\tB-Disease\nduring\tO\ninduction\tO\nwith\tO\ntarget\tO\n-\tO\ncontrolled\tO\npropofol\tB-Chemical\nand\tO\nremifentanil\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nPain\tB-Disease\non\tO\ninjection\tO\nof\tO\npropofol\tB-Chemical\nis\tO\nunpleasant\tO\n.\tO\n\nWe\tO\nhypothesized\tO\nthat\tO\npropofol\tB-Chemical\ninfusion\tO\npain\tB-Disease\nmight\tO\nbe\tO\nprevented\tO\nby\tO\ninfusing\tO\nremifentanil\tB-Chemical\nbefore\tO\nstarting\tO\nthe\tO\npropofol\tB-Chemical\ninfusion\tO\nin\tO\na\tO\nclinical\tO\nsetting\tO\nwhere\tO\ntarget\tO\n-\tO\ncontrolled\tO\ninfusions\tO\n(\tO\nTCI\tO\n)\tO\nof\tO\nboth\tO\ndrugs\tO\nwere\tO\nused\tO\n.\tO\n\nA\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrial\tO\nwas\tO\nperformed\tO\nto\tO\ndetermine\tO\nthe\tO\neffect\tO\n-\tO\nsite\tO\nconcentration\tO\n(\tO\nCe\tO\n)\tO\nof\tO\nremifentanil\tB-Chemical\nto\tO\nprevent\tO\nthe\tO\npain\tB-Disease\nwithout\tO\nproducing\tO\ncomplications\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n128\tO\npatients\tO\nundergoing\tO\ngeneral\tO\nsurgery\tO\nwere\tO\nrandomly\tO\nallocated\tO\nto\tO\nreceive\tO\nnormal\tO\nsaline\tO\n(\tO\ncontrol\tO\n)\tO\nor\tO\nremifentanil\tB-Chemical\nto\tO\na\tO\ntarget\tO\nCe\tO\nof\tO\n2\tO\nng\tO\nml\tO\n(\tO\n-\tO\n1\tO\n)\tO\n(\tO\nR2\tO\n)\tO\n,\tO\n4\tO\nng\tO\nml\tO\n(\tO\n-\tO\n1\tO\n)\tO\n(\tO\nR4\tO\n)\tO\n,\tO\nor\tO\n6\tO\nng\tO\nml\tO\n(\tO\n-\tO\n1\tO\n)\tO\n(\tO\nR6\tO\n)\tO\nadministered\tO\nvia\tO\nTCI\tO\n.\tO\n\nAfter\tO\nthe\tO\ntarget\tO\nCe\tO\nwas\tO\nachieved\tO\n,\tO\nthe\tO\ninfusion\tO\nof\tO\npropofol\tB-Chemical\nwas\tO\nstarted\tO\n.\tO\n\nRemifentanil\tB-Chemical\n-\tO\nrelated\tO\ncomplications\tO\nwere\tO\nassessed\tO\nduring\tO\nthe\tO\nremifentanil\tB-Chemical\ninfusion\tO\n,\tO\nand\tO\npain\tB-Disease\ncaused\tO\nby\tO\npropofol\tB-Chemical\nwas\tO\nevaluated\tO\nusing\tO\na\tO\nfour\tO\n-\tO\npoint\tO\nscale\tO\nduring\tO\nthe\tO\npropofol\tB-Chemical\ninfusion\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nincidence\tO\nof\tO\npain\tB-Disease\nwas\tO\nsignificantly\tO\nlower\tO\nin\tO\nGroups\tO\nR4\tO\nand\tO\nR6\tO\nthan\tO\nin\tO\nthe\tO\ncontrol\tO\nand\tO\nR2\tO\ngroups\tO\n(\tO\n12\tO\n/\tO\n32\tO\nand\tO\n6\tO\n/\tO\n31\tO\nvs\tO\n26\tO\n/\tO\n31\tO\nand\tO\n25\tO\n/\tO\n32\tO\n,\tO\nrespectively\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nPain\tB-Disease\nwas\tO\nless\tO\nsevere\tO\nin\tO\nGroups\tO\nR4\tO\nand\tO\nR6\tO\nthan\tO\nin\tO\nthe\tO\ncontrol\tO\nand\tO\nR2\tO\ngroups\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nboth\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\npain\tB-Disease\nwere\tO\nnot\tO\ndifferent\tO\nbetween\tO\nGroups\tO\nR4\tO\nand\tO\nR6\tO\n.\tO\n\nNo\tO\nsignificant\tO\ncomplications\tO\nwere\tO\nobserved\tO\nduring\tO\nthe\tO\nstudy\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDuring\tO\ninduction\tO\nof\tO\nanaesthesia\tO\nwith\tO\nTCI\tO\nof\tO\npropofol\tB-Chemical\nand\tO\nremifentanil\tB-Chemical\n,\tO\na\tO\nsignificant\tO\nreduction\tO\nin\tO\npropofol\tB-Chemical\ninfusion\tO\npain\tB-Disease\nwas\tO\nachieved\tO\nwithout\tO\nsignificant\tO\ncomplications\tO\nby\tO\nprior\tO\nadministration\tO\nof\tO\nremifentanil\tB-Chemical\nat\tO\na\tO\ntarget\tO\nCe\tO\nof\tO\n4\tO\nng\tO\nml\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nDexmedetomidine\tB-Chemical\nand\tO\ncardiac\tO\nprotection\tO\nfor\tO\nnon\tO\n-\tO\ncardiac\tO\nsurgery\tO\n:\tO\na\tO\nmeta\tO\n-\tO\nanalysis\tO\nof\tO\nrandomised\tO\ncontrolled\tO\ntrials\tO\n.\tO\n\nWe\tO\nconducted\tO\na\tO\nsystematic\tO\nreview\tO\nof\tO\nthe\tO\neffects\tO\nof\tO\ndexmedetomidine\tB-Chemical\non\tO\ncardiac\tO\noutcomes\tO\nfollowing\tO\nnon\tO\n-\tO\ncardiac\tO\nsurgery\tO\n.\tO\n\nWe\tO\nincluded\tO\nprospective\tO\n,\tO\nrandomised\tO\nperi\tO\n-\tO\noperative\tO\nstudies\tO\nof\tO\ndexmedetomidine\tB-Chemical\nthat\tO\nreported\tO\nmortality\tO\n,\tO\ncardiac\tO\nmorbidity\tO\nor\tO\nadverse\tO\ndrug\tO\nevents\tO\n.\tO\n\nA\tO\nPubMed\tO\nCentral\tO\nand\tO\nEMBASE\tO\nsearch\tO\nwas\tO\nconducted\tO\nup\tO\nto\tO\nJuly\tO\n2007\tO\n.\tO\n\nThe\tO\nreference\tO\nlists\tO\nof\tO\nidentified\tO\npapers\tO\nwere\tO\nexamined\tO\nfor\tO\nfurther\tO\ntrials\tO\n.\tO\n\nOf\tO\n425\tO\nstudies\tO\nidentified\tO\n,\tO\n20\tO\nwere\tO\nincluded\tO\nin\tO\nthe\tO\nmeta\tO\n-\tO\nanalysis\tO\n(\tO\n840\tO\npatients\tO\n)\tO\n.\tO\n\nDexmedetomidine\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\na\tO\ntrend\tO\ntowards\tO\nimproved\tO\ncardiac\tO\noutcomes\tO\n;\tO\nall\tO\n-\tO\ncause\tO\nmortality\tO\n(\tO\nOR\tO\n0\tO\n.\tO\n27\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n01\tO\n-\tO\n7\tO\n.\tO\n13\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n44\tO\n)\tO\n,\tO\nnon\tO\n-\tO\nfatal\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n(\tO\nOR\tO\n0\tO\n.\tO\n26\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n04\tO\n-\tO\n1\tO\n.\tO\n60\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n14\tO\n)\tO\n,\tO\nand\tO\nmyocardial\tB-Disease\nischaemia\tI-Disease\n(\tO\nOR\tO\n0\tO\n.\tO\n65\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n26\tO\n-\tO\n1\tO\n.\tO\n63\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n36\tO\n)\tO\n.\tO\n\nPeri\tO\n-\tO\noperative\tO\nhypotension\tB-Disease\n(\tO\n26\tO\n%\tO\n,\tO\nOR\tO\n3\tO\n.\tO\n80\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n91\tO\n-\tO\n7\tO\n.\tO\n54\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n0001\tO\n)\tO\nand\tO\nbradycardia\tB-Disease\n(\tO\n17\tO\n%\tO\n,\tO\nOR\tO\n5\tO\n.\tO\n45\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n2\tO\n.\tO\n98\tO\n-\tO\n9\tO\n.\tO\n95\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n00001\tO\n)\tO\nwere\tO\nsignificantly\tO\nincreased\tO\n.\tO\n\nAn\tO\nanticholinergic\tO\ndid\tO\nnot\tO\nreduce\tO\nthe\tO\nincidence\tO\nof\tO\nbradycardia\tB-Disease\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n43\tO\n)\tO\n.\tO\n\nA\tO\nrandomised\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrial\tO\nof\tO\ndexmedetomidine\tB-Chemical\nis\tO\nwarranted\tO\n.\tO\n\nMyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\npregnancy\tO\nassociated\tO\nwith\tO\nclomiphene\tB-Chemical\ncitrate\tI-Chemical\nfor\tO\novulation\tO\ninduction\tO\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nClomiphene\tB-Chemical\ncitrate\tI-Chemical\n(\tO\nCC\tB-Chemical\n)\tO\nis\tO\ncommonly\tO\nprescribed\tO\nfor\tO\novulation\tO\ninduction\tO\n.\tO\n\nIt\tO\nis\tO\nconsidered\tO\nsafe\tO\n,\tO\nwith\tO\nminimal\tO\nside\tO\neffects\tO\n.\tO\n\nThromboembolism\tB-Disease\nis\tO\na\tO\nrare\tO\nbut\tO\nlife\tO\n-\tO\nthreatening\tO\ncomplication\tO\nthat\tO\nhas\tO\nbeen\tO\nreported\tO\nafter\tO\novulation\tO\ninduction\tO\nwith\tO\nCC\tB-Chemical\n.\tO\n\nSpontaneous\tO\ncoronary\tB-Disease\nthrombosis\tI-Disease\nor\tO\nthromboembolism\tB-Disease\nwith\tO\nsubsequent\tO\nclot\tO\nlysis\tO\nhas\tO\nbeen\tO\nsuggested\tO\nas\tO\none\tO\nof\tO\nthe\tO\nmost\tO\ncommon\tO\ncauses\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n(\tO\nMI\tB-Disease\n)\tO\nduring\tO\npregnancy\tO\n,\tO\nwith\tO\na\tO\nsubsequently\tO\nnormal\tO\ncoronary\tO\nangiogram\tO\n.\tO\n\nCASE\tO\n:\tO\nA\tO\n33\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\na\tO\n5\tO\n-\tO\nweek\tO\ngestation\tO\nhad\tO\nrecently\tO\nreceived\tO\nCC\tB-Chemical\nfor\tO\novulation\tO\ninduction\tO\nand\tO\npresented\tO\nwith\tO\nchest\tB-Disease\npain\tI-Disease\n.\tO\n\nAn\tO\nelectrocardiogram\tO\nshowed\tO\na\tO\nlateral\tO\nand\tO\nanterior\tO\nwall\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nCardiac\tO\nenzymes\tO\nshowed\tO\na\tO\npeak\tO\nrise\tO\nin\tO\ntroponin\tO\nI\tO\nto\tO\n9\tO\n.\tO\n10\tO\nng\tO\n/\tO\nmL\tO\n.\tO\n\nAn\tO\ninitial\tO\nexercise\tO\nstress\tO\ntest\tO\nwas\tO\nnormal\tO\n.\tO\n\nAt\tO\nthe\tO\ntime\tO\nof\tO\nadmission\tO\n,\tO\nthe\tO\npatient\tO\nwas\tO\nat\tO\nhigh\tO\nrisk\tO\nof\tO\nradiation\tB-Disease\ninjury\tI-Disease\nto\tO\nthe\tO\nfetus\tO\n,\tO\nso\tO\na\tO\ncoronary\tO\nangiogram\tO\nwas\tO\npostponed\tO\nuntil\tO\nthe\tO\nsecond\tO\ntrimester\tO\n.\tO\n\nIt\tO\nshowed\tO\nnormal\tO\ncoronary\tO\nvessels\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nappears\tO\nto\tO\nbe\tO\nthe\tO\nfirst\tO\nreported\tO\ncase\tO\ndocumenting\tO\na\tO\npossible\tO\nassociation\tO\nbetween\tO\nCC\tB-Chemical\nand\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nThrombosis\tB-Disease\nmight\tO\nbe\tO\na\tO\nrare\tO\nbut\tO\nhazardous\tO\ncomplication\tO\nof\tO\nCC\tB-Chemical\n.\tO\n\nGiven\tO\nthis\tO\nlife\tO\n-\tO\nthreatening\tO\ncomplication\tO\n,\tO\nappropriate\tO\nprophylactic\tO\nmeasures\tO\nshould\tO\nbe\tO\nused\tO\nin\tO\nhigh\tO\n-\tO\nrisk\tO\nwoman\tO\nundergoing\tO\novarian\tO\nstimulation\tO\n.\tO\n\nReverse\tO\nor\tO\ninverted\tO\nleft\tB-Disease\nventricular\tI-Disease\napical\tI-Disease\nballooning\tI-Disease\nsyndrome\tI-Disease\n(\tO\nreverse\tO\nTakotsubo\tB-Disease\ncardiomyopathy\tI-Disease\n)\tO\nin\tO\na\tO\nyoung\tO\nwoman\tO\nin\tO\nthe\tO\nsetting\tO\nof\tO\namphetamine\tB-Chemical\nuse\tO\n.\tO\n\nTransient\tO\nleft\tB-Disease\nventricular\tI-Disease\napical\tI-Disease\nballooning\tI-Disease\nsyndrome\tI-Disease\nwas\tO\nfirst\tO\ndescribed\tO\nin\tO\nJapan\tO\nas\tO\n\"\tO\nTakotsubo\tB-Disease\ncardiomyopathy\tI-Disease\n.\tO\n\"\tO\nThis\tO\nsyndrome\tO\nhas\tO\nbeen\tO\nidentified\tO\nin\tO\nmany\tO\nother\tO\ncountries\tO\n.\tO\n\nMany\tO\nvariations\tO\nof\tO\nthis\tO\nsyndrome\tO\nhave\tO\nbeen\tO\nrecently\tO\ndescribed\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nOne\tO\nof\tO\nthe\tO\nrarest\tO\nis\tO\nthe\tO\nreverse\tO\ntype\tO\nof\tO\nthis\tO\nsyndrome\tO\n,\tO\nwith\tO\nhyperdynamic\tO\napex\tO\nand\tO\ncomplete\tO\nakinesia\tB-Disease\nof\tO\nthe\tO\nbase\tO\n(\tO\nas\tO\nopposed\tO\nto\tO\nthe\tO\nclassic\tO\napical\tB-Disease\nballooning\tI-Disease\n)\tO\n.\tO\n\nIn\tO\nthis\tO\narticle\tO\n,\tO\nwe\tO\nreport\tO\nan\tO\ninteresting\tO\ncase\tO\nof\tO\na\tO\nyoung\tO\nwoman\tO\nwho\tO\npresented\tO\nwith\tO\nthis\tO\nrare\tO\ntype\tO\nof\tO\nreverse\tO\napical\tB-Disease\nballooning\tI-Disease\nsyndrome\tI-Disease\noccurring\tO\nafter\tO\namphetamine\tB-Chemical\nuse\tO\n.\tO\n\nThis\tO\nreport\tO\nis\tO\nfollowed\tO\nby\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\n.\tO\n\nResults\tO\nof\tO\na\tO\ncomparative\tO\n,\tO\nphase\tO\nIII\tO\n,\tO\n12\tO\n-\tO\nweek\tO\n,\tO\nmulticenter\tO\n,\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\nassessment\tO\nof\tO\nthe\tO\nefficacy\tO\nand\tO\ntolerability\tO\nof\tO\na\tO\nfixed\tO\n-\tO\ndose\tO\ncombination\tO\nof\tO\ntelmisartan\tB-Chemical\nand\tO\namlodipine\tB-Chemical\nversus\tO\namlodipine\tB-Chemical\nmonotherapy\tO\nin\tO\nIndian\tO\nadults\tO\nwith\tO\nstage\tO\nII\tO\nhypertension\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nevaluate\tO\nthe\tO\nefficacy\tO\nand\tO\ntolerability\tO\nof\tO\na\tO\nnew\tO\nfixed\tO\n-\tO\ndose\tO\ncombination\tO\n(\tO\nFDC\tO\n)\tO\nof\tO\ntelmisartan\tB-Chemical\n40\tO\nmg\tO\n+\tO\namlodipine\tB-Chemical\n5\tO\nmg\tO\n(\tO\nT\tO\n+\tO\nA\tO\n)\tO\ncompared\tO\nwith\tO\namlodipine\tB-Chemical\n5\tO\n-\tO\nmg\tO\nmonotherapy\tO\n(\tO\nA\tO\n)\tO\nin\tO\nadult\tO\nIndian\tO\npatients\tO\nwith\tO\nstage\tO\nII\tO\nhypertension\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\ncomparative\tO\n,\tO\nPhase\tO\nIII\tO\n,\tO\n12\tO\n-\tO\nweek\tO\n,\tO\nmulticenter\tO\n,\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\nwas\tO\nconducted\tO\nin\tO\nIndian\tO\npatients\tO\naged\tO\n18\tO\nto\tO\n65\tO\nyears\tO\nwith\tO\nestablished\tO\nstage\tO\nII\tO\nhypertension\tB-Disease\n.\tO\n\nPatients\tO\nwere\tO\ntreated\tO\nwith\tO\noral\tO\nFDC\tO\nof\tO\nT\tO\n+\tO\nA\tO\nor\tO\nA\tO\nQD\tO\nbefore\tO\nbreakfast\tO\nfor\tO\n12\tO\nweeks\tO\n;\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\nand\tO\nheart\tO\nrate\tO\nwere\tO\nmeasured\tO\nin\tO\nthe\tO\nsitting\tO\nposition\tO\n.\tO\n\nPrimary\tO\nefficacy\tO\nend\tO\npoints\tO\nwere\tO\nreduction\tO\nin\tO\nclinical\tO\nsystolic\tO\nBP\tO\n(\tO\nSBP\tO\n)\tO\n/\tO\ndiastolic\tO\nBP\tO\n(\tO\nDBP\tO\n)\tO\nfrom\tO\nbaseline\tO\nto\tO\nstudy\tO\nend\tO\nand\tO\nnumber\tO\nof\tO\nresponders\tO\n(\tO\nie\tO\n,\tO\npatients\tO\nwho\tO\nachieved\tO\ntarget\tO\nSBP\tO\n/\tO\nDBP\tO\n<\tO\n130\tO\n/\tO\n<\tO\n80\tO\nmm\tO\nHg\tO\n)\tO\nat\tO\nend\tO\nof\tO\nstudy\tO\n.\tO\n\nTolerability\tO\nwas\tO\nassessed\tO\nby\tO\ntreatment\tO\n-\tO\nemergent\tO\nadverse\tO\nevents\tO\n,\tO\nidentified\tO\nusing\tO\nphysical\tO\nexamination\tO\n,\tO\nlaboratory\tO\nanalysis\tO\n,\tO\nand\tO\nelectrocardiography\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n210\tO\npatients\tO\nwere\tO\nenrolled\tO\nin\tO\nthe\tO\nstudy\tO\n;\tO\n203\tO\npatients\tO\n(\tO\n143\tO\nmen\tO\n,\tO\n60\tO\nwomen\tO\n)\tO\ncompleted\tO\nthe\tO\nstudy\tO\nwhile\tO\n7\tO\nwere\tO\nlost\tO\nto\tO\nfollow\tO\n-\tO\nup\tO\n(\tO\n4\tO\npatients\tO\nin\tO\nthe\tO\nT\tO\n+\tO\nA\tO\ngroup\tO\nand\tO\n3\tO\nin\tO\nthe\tO\nA\tO\ngroup\tO\n)\tO\nand\tO\nconsidered\tO\nwith\tO\n-\tO\ndrawn\tO\n.\tO\n\nAt\tO\nstudy\tO\nend\tO\n,\tO\nstatistically\tO\nsignificant\tO\npercentage\tO\nreductions\tO\nfrom\tO\nbaseline\tO\nwithin\tO\ngroups\tO\nand\tO\nbetween\tO\ngroups\tO\nwere\tO\nobserved\tO\nin\tO\nSBP\tO\n(\tO\nT\tO\n+\tO\nA\tO\n[\tO\n-\tO\n27\tO\n.\tO\n4\tO\n%\tO\n]\tO\n;\tO\nA\tO\n[\tO\n-\tO\n16\tO\n.\tO\n6\tO\n%\tO\n]\tO\n)\tO\nand\tO\nDBP\tO\n(\tO\nT\tO\n+\tO\nA\tO\n[\tO\n-\tO\n20\tO\n.\tO\n1\tO\n%\tO\n]\tO\n;\tO\nA\tO\n[\tO\n-\tO\n13\tO\n.\tO\n3\tO\n%\tO\n]\tO\n)\tO\n(\tO\nall\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nResponse\tO\nrates\tO\nwere\tO\n87\tO\n.\tO\n3\tO\n%\tO\n(\tO\n89\tO\n/\tO\n102\tO\n)\tO\nin\tO\nthe\tO\nT\tO\n+\tO\nA\tO\ngroup\tO\nand\tO\n69\tO\n.\tO\n3\tO\n%\tO\n(\tO\n70\tO\n/\tO\n101\tO\n)\tO\nin\tO\nthe\tO\nA\tO\ngroup\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\nprevalences\tO\nof\tO\nadverse\tO\nevents\tO\nwere\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\nbetween\tO\nthe\tO\n2\tO\ntreatment\tO\ngroups\tO\n(\tO\nT\tO\n+\tO\nA\tO\n,\tO\n16\tO\n.\tO\n0\tO\n%\tO\n[\tO\n17\tO\n/\tO\n106\tO\n]\tO\n;\tO\nA\tO\n,\tO\n15\tO\n.\tO\n4\tO\n%\tO\n[\tO\n16\tO\n/\tO\n104\tO\n]\tO\n)\tO\n.\tO\n\nPeripheral\tO\nedema\tB-Disease\nwas\tO\nreported\tO\nin\tO\n8\tO\n.\tO\n5\tO\n%\tO\npatients\tO\n(\tO\n9\tO\n/\tO\n106\tO\n)\tO\nin\tO\nthe\tO\nT\tO\n+\tO\nA\tO\ngroup\tO\ncompared\tO\nwith\tO\n13\tO\n.\tO\n5\tO\n%\tO\n(\tO\n14\tO\n/\tO\n104\tO\n)\tO\nin\tO\nthe\tO\nA\tO\ngroup\tO\n,\tO\nand\tO\ncough\tB-Disease\nwas\tO\nreported\tO\nin\tO\n3\tO\n.\tO\n8\tO\n%\tO\npatients\tO\n(\tO\n4\tO\n/\tO\n106\tO\n)\tO\nin\tO\nthe\tO\nT\tO\n+\tO\nA\tO\ngroup\tO\nand\tO\n1\tO\n.\tO\n0\tO\n%\tO\n(\tO\n1\tO\n/\tO\n104\tO\n)\tO\npatients\tO\nin\tO\nthe\tO\nA\tO\ngroup\tO\n;\tO\nthese\tO\ndifferences\tO\ndid\tO\nnot\tO\nreach\tO\nstatistical\tO\nsignificance\tO\n.\tO\n\nThe\tO\nincidences\tO\nof\tO\nheadache\tB-Disease\n,\tO\ndizziness\tB-Disease\n,\tO\nand\tO\ndiarrhea\tB-Disease\nwere\tO\nsimilar\tO\nbetween\tO\nthe\tO\n2\tO\ngroups\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAmong\tO\nthese\tO\nIndian\tO\npatients\tO\nwith\tO\nstage\tO\nII\tO\nhypertension\tB-Disease\n,\tO\nthe\tO\nFDC\tO\nof\tO\nT\tO\n+\tO\nA\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\nsignificantly\tO\nmore\tO\neffective\tO\n,\tO\nwith\tO\nregard\tO\nto\tO\nBP\tO\nreductions\tO\n,\tO\nthan\tO\nA\tO\n,\tO\nand\tO\nboth\tO\ntreatments\tO\nwere\tO\nwell\tO\ntolerated\tO\n.\tO\n\nIncreased\tO\nmental\tB-Disease\nslowing\tI-Disease\nassociated\tO\nwith\tO\nthe\tO\nAPOE\tO\nepsilon4\tO\nallele\tO\nafter\tO\ntrihexyphenidyl\tB-Chemical\noral\tO\nanticholinergic\tO\nchallenge\tO\nin\tO\nhealthy\tO\nelderly\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nobjectives\tO\nof\tO\nthis\tO\nstudy\tO\nwere\tO\nto\tO\nexamine\tO\nthe\tO\nrelationship\tO\nbetween\tO\nAPOE\tO\nepsilon4\tO\nand\tO\nsubjective\tO\neffects\tO\nof\tO\ntrihexyphenidyl\tB-Chemical\non\tO\nmeasures\tO\nreflecting\tO\nsedation\tO\nand\tO\nconfusion\tB-Disease\nand\tO\nto\tO\ninvestigate\tO\nthe\tO\nrelationship\tO\nbetween\tO\ntrihexyphenidyl\tB-Chemical\n-\tO\ninduced\tO\nsubjective\tO\neffects\tO\nand\tO\nobjective\tO\nmemory\tO\nperformance\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nstudy\tO\ncomprised\tO\n24\tO\ncognitively\tO\nintact\tO\n,\tO\nhealth\tO\nelderly\tO\nadults\tO\n(\tO\n12\tO\nAPOE\tO\nepsilon4\tO\ncarriers\tO\n)\tO\nat\tO\nan\tO\noutpatient\tO\ngeriatric\tO\npsychiatry\tO\nresearch\tO\nclinic\tO\n.\tO\n\nThis\tO\nwas\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\nthree\tO\n-\tO\nway\tO\n,\tO\ncrossover\tO\nexperimental\tO\ndesign\tO\n.\tO\n\nAll\tO\nparticipants\tO\nreceived\tO\n1\tO\n.\tO\n0\tO\nmg\tO\nor\tO\n2\tO\n.\tO\n0\tO\nmg\tO\ntrihexyphenidyl\tB-Chemical\nor\tO\nplacebo\tO\nadministered\tO\nin\tO\ncounterbalanced\tO\nsequences\tO\nover\tO\na\tO\nperiod\tO\nof\tO\nthree\tO\nconsecutive\tO\nweeks\tO\n.\tO\n\nBond\tO\nand\tO\nLader\tO\n'\tO\ns\tO\nvisual\tO\nanalog\tO\nscales\tO\nand\tO\nalternate\tO\nversions\tO\nof\tO\nthe\tO\nBuschke\tO\nSelective\tO\nReminding\tO\nTest\tO\nwere\tO\nadministered\tO\nin\tO\na\tO\nrepeated\tO\nmeasures\tO\ndesign\tO\nat\tO\nbaseline\tO\n,\tO\n1\tO\n,\tO\n2\tO\n.\tO\n5\tO\n,\tO\nand\tO\n5\tO\nhours\tO\npostdrug\tO\nadministration\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\n2\tO\n.\tO\n0\tO\n-\tO\nmg\tO\noral\tO\ndose\tO\nof\tO\ntrihexyphenidyl\tB-Chemical\nresulted\tO\nin\tO\nincreased\tO\nsubjective\tO\nratings\tO\nof\tO\nmental\tB-Disease\nslowness\tI-Disease\nin\tO\ncarriers\tO\nof\tO\nthe\tO\nAPOE\tO\nepsilon4\tO\nallele\tO\nonly\tO\n.\tO\n\nDrug\tO\neffects\tO\nas\tO\ndetermined\tO\nby\tO\ndifference\tO\nscores\tO\nbetween\tO\n2\tO\n.\tO\n0\tO\nmg\tO\ntrihexyphenidyl\tB-Chemical\nand\tO\nplacebo\tO\non\tO\nratings\tO\nof\tO\nmental\tB-Disease\nslowness\tI-Disease\nsignificantly\tO\ncorrelated\tO\nwith\tO\ntotal\tO\nand\tO\ndelayed\tO\nrecall\tO\non\tO\nthe\tO\nBuschke\tO\nSelective\tO\nReminding\tO\nTest\tO\nin\tO\ncarriers\tO\nof\tO\nthe\tO\nAPOE\tO\nepsilon4\tO\nallele\tO\nonly\tO\n.\tO\n\nHowever\tO\n,\tO\nno\tO\nsignificant\tO\neffects\tO\nwere\tO\nfound\tO\nwith\tO\nother\tO\nvisual\tO\nanalog\tO\nscales\tO\nreflecting\tO\nsubjective\tO\nsedation\tO\nand\tO\nclear\tO\n-\tO\nheadedness\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nepsilon4\tO\nallele\tO\nin\tO\nhealthy\tO\nelderly\tO\nwas\tO\nassociated\tO\nwith\tO\nincreased\tO\nsubjective\tO\nmental\tB-Disease\nslowing\tI-Disease\nafter\tO\ntrihexyphenidyl\tB-Chemical\nanticholinergic\tO\nchallenge\tO\n.\tO\n\nAn\tO\nevaluation\tO\nof\tO\namikacin\tB-Chemical\nnephrotoxicity\tB-Disease\nin\tO\nthe\tO\nhematology\tO\n/\tO\noncology\tO\npopulation\tO\n.\tO\n\nAmikacin\tB-Chemical\nis\tO\nan\tO\naminoglycoside\tB-Chemical\ncommonly\tO\nused\tO\nto\tO\nprovide\tO\nempirical\tO\ndouble\tO\ngram\tO\n-\tO\nnegative\tO\ntreatment\tO\nfor\tO\nfebrile\tB-Disease\nneutropenia\tI-Disease\nand\tO\nother\tO\nsuspected\tO\ninfections\tB-Disease\n.\tO\n\nStrategies\tO\nof\tO\nextended\tO\n-\tO\ninterval\tO\nand\tO\nconventional\tO\ndosing\tO\nhave\tO\nbeen\tO\nutilized\tO\nextensively\tO\nin\tO\nthe\tO\ngeneral\tO\nmedical\tO\npopulation\tO\n;\tO\nhowever\tO\n,\tO\ndata\tO\nare\tO\nlacking\tO\nto\tO\nsupport\tO\na\tO\ndosing\tO\nstrategy\tO\nin\tO\nthe\tO\nhematology\tO\n/\tO\noncology\tO\npopulation\tO\n.\tO\n\nTo\tO\nevaluate\tO\namikacin\tB-Chemical\n-\tO\nassociated\tO\nnephrotoxicity\tB-Disease\nin\tO\nan\tO\nadult\tO\nhematology\tO\n/\tO\noncology\tO\npopulation\tO\n,\tO\na\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\nopen\tO\n-\tO\nlabel\tO\ntrial\tO\nwas\tO\nconducted\tO\nat\tO\na\tO\nuniversity\tO\n-\tO\naffiliated\tO\nmedical\tO\ncenter\tO\n.\tO\n\nForty\tO\npatients\tO\nwith\tO\na\tO\ndiagnosis\tO\nconsistent\tO\nwith\tO\na\tO\nhematologic\tB-Disease\n/\tI-Disease\noncologic\tI-Disease\ndisorder\tI-Disease\nthat\tO\nrequired\tO\ntreatment\tO\nwith\tO\nan\tO\naminoglycoside\tB-Chemical\nwere\tO\nrandomized\tO\nto\tO\neither\tO\nconventional\tO\nor\tO\nextended\tO\n-\tO\ninterval\tO\namikacin\tB-Chemical\n.\tO\n\nThe\tO\noccurrence\tO\nof\tO\nnephrotoxicity\tB-Disease\nby\tO\nmeans\tO\nof\tO\nan\tO\nincrease\tO\nin\tO\nserum\tO\ncreatinine\tB-Chemical\nand\tO\nevaluation\tO\nof\tO\nefficacy\tO\nvia\tO\namikacin\tB-Chemical\nserum\tO\nconcentrations\tO\nwith\tO\nrespective\tO\npathogens\tO\nwere\tO\nassessed\tO\n.\tO\n\nThe\tO\noccurrence\tO\nof\tO\nnephrotoxicity\tB-Disease\nwas\tO\nsimilar\tO\nbetween\tO\nthe\tO\nconventional\tO\nand\tO\nextended\tO\n-\tO\ninterval\tO\ngroups\tO\n,\tO\nat\tO\n10\tO\n%\tO\nand\tO\n5\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\nP\tO\n=\tO\n1\tO\n.\tO\n00\tO\n)\tO\n.\tO\n\nSix\tO\npatients\tO\nin\tO\nthe\tO\nconventional\tO\ngroup\tO\nhad\tO\na\tO\npositive\tO\nculture\tO\n,\tO\ncompared\tO\nwith\tO\nnone\tO\nin\tO\nthe\tO\nextended\tO\n-\tO\ninterval\tO\ngroup\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nThe\tO\noccurrence\tO\nof\tO\nnephrotoxicity\tB-Disease\nwas\tO\nsimilar\tO\nbetween\tO\nthe\tO\ntwo\tO\ndosing\tO\nregimens\tO\n,\tO\nbut\tO\nthe\tO\ndistribution\tO\nof\tO\nrisk\tO\nfactors\tO\nwas\tO\nvariable\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nEfficacy\tO\ncould\tO\nnot\tO\nbe\tO\nassessed\tO\n.\tO\n\nHigh\tO\ndose\tO\ndexmedetomidine\tB-Chemical\nas\tO\nthe\tO\nsole\tO\nsedative\tO\nfor\tO\npediatric\tO\nMRI\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThis\tO\nlarge\tO\n-\tO\nscale\tO\nretrospective\tO\nreview\tO\nevaluates\tO\nthe\tO\nsedation\tO\nprofile\tO\nof\tO\ndexmedetomidine\tB-Chemical\n.\tO\n\nAIM\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nhemodynamic\tO\nresponses\tO\n,\tO\nefficacy\tO\nand\tO\nadverse\tO\nevents\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nhigh\tO\ndose\tO\ndexmedetomidine\tB-Chemical\nas\tO\nthe\tO\nsole\tO\nsedative\tO\nfor\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n(\tO\nMRI\tO\n)\tO\nstudies\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nDexmedetomidine\tB-Chemical\nhas\tO\nbeen\tO\nused\tO\nat\tO\nour\tO\ninstitution\tO\nsince\tO\n2005\tO\nto\tO\nprovide\tO\nsedation\tO\nfor\tO\npediatric\tO\nradiological\tO\nimaging\tO\nstudies\tO\n.\tO\n\nOver\tO\ntime\tO\n,\tO\nan\tO\neffective\tO\nprotocol\tO\nutilizing\tO\nhigh\tO\ndose\tO\ndexmedetomidine\tB-Chemical\nas\tO\nthe\tO\nsole\tO\nsedative\tO\nagent\tO\nhas\tO\nevolved\tO\n.\tO\n\nMETHODS\tO\n/\tO\nMATERIALS\tO\n:\tO\nAs\tO\npart\tO\nof\tO\nthe\tO\nongoing\tO\nQuality\tO\nAssurance\tO\nprocess\tO\n,\tO\ndata\tO\non\tO\nall\tO\nsedations\tO\nare\tO\nreviewed\tO\nmonthly\tO\nand\tO\nprotocols\tO\nmodified\tO\nas\tO\nneeded\tO\n.\tO\n\nData\tO\nwere\tO\nanalyzed\tO\nfrom\tO\nall\tO\n747\tO\nconsecutive\tO\npatients\tO\nwho\tO\nreceived\tO\ndexmedetomidine\tB-Chemical\nfor\tO\nMRI\tO\nsedation\tO\nfrom\tO\nApril\tO\n2005\tO\nto\tO\nApril\tO\n2007\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSince\tO\n2005\tO\n,\tO\nthe\tO\n10\tO\n-\tO\nmin\tO\nloading\tO\ndose\tO\nof\tO\nour\tO\ndexmedetomidine\tB-Chemical\nprotocol\tO\nincreased\tO\nfrom\tO\n2\tO\nto\tO\n3\tO\nmicrog\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n,\tO\nand\tO\nthe\tO\ninfusion\tO\nrate\tO\nincreased\tO\nfrom\tO\n1\tO\nto\tO\n1\tO\n.\tO\n5\tO\nto\tO\n2\tO\nmicrog\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\nh\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nThe\tO\ncurrent\tO\nsedation\tO\nprotocol\tO\nprogressively\tO\nincreased\tO\nthe\tO\nrate\tO\nof\tO\nsuccessful\tO\nsedation\tO\n(\tO\nable\tO\nto\tO\ncomplete\tO\nthe\tO\nimaging\tO\nstudy\tO\n)\tO\nwhen\tO\nusing\tO\ndexmedetomidine\tB-Chemical\nalone\tO\nfrom\tO\n91\tO\n.\tO\n8\tO\n%\tO\nto\tO\n97\tO\n.\tO\n6\tO\n%\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n009\tO\n)\tO\n,\tO\nreducing\tO\nthe\tO\nrequirement\tO\nfor\tO\nadjuvant\tO\npentobarbital\tB-Chemical\nin\tO\nthe\tO\nevent\tO\nof\tO\nsedation\tO\nfailure\tO\nwith\tO\ndexmedetomidine\tB-Chemical\nalone\tO\nand\tO\ndecreased\tO\nthe\tO\nmean\tO\nrecovery\tO\ntime\tO\nby\tO\n10\tO\nmin\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nAlthough\tO\ndexmedetomidine\tB-Chemical\nsedation\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\n16\tO\n%\tO\nincidence\tO\nof\tO\nbradycardia\tB-Disease\n,\tO\nall\tO\nconcomitant\tO\nmean\tO\narterial\tO\nblood\tO\npressures\tO\nwere\tO\nwithin\tO\n20\tO\n%\tO\nof\tO\nage\tO\n-\tO\nadjusted\tO\nnormal\tO\nrange\tO\nand\tO\noxygen\tB-Chemical\nsaturations\tO\nwere\tO\n95\tO\n%\tO\nor\tO\nhigher\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nDexmedetomidine\tB-Chemical\nin\tO\nhigh\tO\ndoses\tO\nprovides\tO\nadequate\tO\nsedation\tO\nfor\tO\npediatric\tO\nMRI\tO\nstudies\tO\n.\tO\n\nWhile\tO\nuse\tO\nof\tO\nhigh\tO\ndose\tO\ndexmedetomidine\tB-Chemical\nis\tO\nassociated\tO\nwith\tO\ndecreases\tO\nin\tO\nheart\tO\nrate\tO\nand\tO\nblood\tO\npressure\tO\noutside\tO\nthe\tO\nestablished\tO\n'\tO\nawake\tO\n'\tO\nnorms\tO\n,\tO\nthis\tO\ndeviation\tO\nis\tO\ngenerally\tO\nwithin\tO\n20\tO\n%\tO\nof\tO\nnorms\tO\n,\tO\nand\tO\nis\tO\nnot\tO\nassociated\tO\nwith\tO\nadverse\tO\nsequelae\tO\n.\tO\n\nDexmedetomidine\tB-Chemical\nis\tO\nuseful\tO\nas\tO\nthe\tO\nsole\tO\nsedative\tO\nfor\tO\npediatric\tO\nMRI\tO\n.\tO\n\nHepatotoxicity\tB-Disease\nassociated\tO\nwith\tO\nsulfasalazine\tB-Chemical\nin\tO\ninflammatory\tO\narthritis\tB-Disease\n:\tO\nA\tO\ncase\tO\nseries\tO\nfrom\tO\na\tO\nlocal\tO\nsurveillance\tO\nof\tO\nserious\tO\nadverse\tO\nevents\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nSpontaneous\tO\nreporting\tO\nsystems\tO\nfor\tO\nadverse\tO\ndrug\tO\nreactions\tO\n(\tO\nADRs\tO\n)\tO\nare\tO\nhandicapped\tO\nby\tO\nunder\tO\n-\tO\nreporting\tO\nand\tO\nlimited\tO\ndetail\tO\non\tO\nindividual\tO\ncases\tO\n.\tO\n\nWe\tO\nreport\tO\nan\tO\ninvestigation\tO\nfrom\tO\na\tO\nlocal\tO\nsurveillance\tO\nfor\tO\nserious\tO\nadverse\tO\ndrug\tO\nreactions\tO\nassociated\tO\nwith\tO\ndisease\tO\nmodifying\tO\nanti\tO\n-\tO\nrheumatic\tO\ndrugs\tO\nthat\tO\nwas\tO\ntriggered\tO\nby\tO\nthe\tO\noccurrence\tO\nof\tO\nliver\tB-Disease\nfailure\tI-Disease\nin\tO\ntwo\tO\nof\tO\nour\tO\npatients\tO\n.\tO\n\nMETHODS\tO\n:\tO\nSerious\tO\nADR\tO\nreports\tO\nhave\tO\nbeen\tO\nsolicited\tO\nfrom\tO\nlocal\tO\nclinicians\tO\nby\tO\nregular\tO\npostcards\tO\nover\tO\nthe\tO\npast\tO\nseven\tO\nyears\tO\n.\tO\n\nPatients\tO\n'\tO\n,\tO\nwho\tO\nhad\tO\nhepatotoxicity\tB-Disease\non\tO\nsulfasalazine\tB-Chemical\nand\tO\nmet\tO\na\tO\ndefinition\tO\nof\tO\na\tO\nserious\tO\nADR\tO\n,\tO\nwere\tO\nidentified\tO\n.\tO\n\nTwo\tO\nclinicians\tO\nreviewed\tO\nstructured\tO\ncase\tO\nreports\tO\nand\tO\nassessed\tO\ncausality\tO\nby\tO\nconsensus\tO\nand\tO\nby\tO\nusing\tO\na\tO\ncausality\tO\nassessment\tO\ninstrument\tO\n.\tO\n\nThe\tO\nlikely\tO\nfrequency\tO\nof\tO\nhepatotoxicity\tB-Disease\nwith\tO\nsulfasalazine\tB-Chemical\nwas\tO\nestimated\tO\nby\tO\nmaking\tO\na\tO\nseries\tO\nof\tO\nconservative\tO\nassumptions\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTen\tO\ncases\tO\nwere\tO\nidentified\tO\n:\tO\neight\tO\noccurred\tO\nduring\tO\nsurveillance\tO\n.\tO\n\nEight\tO\npatients\tO\nwere\tO\nhospitalised\tO\n,\tO\ntwo\tO\nin\tO\nhepatic\tB-Disease\nfailure\tI-Disease\n-\tO\none\tO\ndied\tO\nafter\tO\na\tO\nliver\tO\ntransplant\tO\n.\tO\n\nAll\tO\nbut\tO\none\tO\nevent\tO\noccurred\tO\nwithin\tO\n6\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nSeven\tO\npatients\tO\nhad\tO\na\tO\nskin\tB-Disease\nrash\tI-Disease\n,\tO\nthree\tO\neosinophilia\tB-Disease\nand\tO\none\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\n.\tO\n\nFive\tO\npatients\tO\nwere\tO\nof\tO\nBlack\tO\nBritish\tO\nof\tO\nAfrican\tO\nor\tO\nCaribbean\tO\ndescent\tO\n.\tO\n\nLiver\tO\nenzymes\tO\nshowed\tO\na\tO\nhepatocellular\tO\npattern\tO\nin\tO\nfour\tO\ncases\tO\nand\tO\na\tO\nmixed\tO\npattern\tO\nin\tO\nsix\tO\n.\tO\n\nDrug\tO\n-\tO\nrelated\tO\nhepatotoxicity\tB-Disease\nwas\tO\njudged\tO\nprobable\tO\nor\tO\nhighly\tO\nprobable\tO\nin\tO\n8\tO\npatients\tO\n.\tO\n\nThe\tO\nlikely\tO\nfrequency\tO\nof\tO\nserious\tO\nhepatotoxicity\tB-Disease\nwith\tO\nsulfasalazine\tB-Chemical\nwas\tO\nestimated\tO\nat\tO\n0\tO\n.\tO\n4\tO\n%\tO\nof\tO\ntreated\tO\npatients\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nSerious\tO\nhepatotoxicity\tB-Disease\nassociated\tO\nwith\tO\nsulfasalazine\tB-Chemical\nappears\tO\nto\tO\nbe\tO\nunder\tO\n-\tO\nappreciated\tO\nand\tO\nintensive\tO\nmonitoring\tO\nand\tO\nvigilance\tO\nin\tO\nthe\tO\nfirst\tO\n6\tO\nweeks\tO\nof\tO\ntreatment\tO\nis\tO\nespecially\tO\nimportant\tO\n.\tO\n\nComplete\tO\natrioventricular\tB-Disease\nblock\tI-Disease\nsecondary\tO\nto\tO\nlithium\tB-Chemical\ntherapy\tO\n.\tO\n\nSinus\tB-Disease\nnode\tI-Disease\ndysfunction\tI-Disease\nhas\tO\nbeen\tO\nreported\tO\nmost\tO\nfrequently\tO\namong\tO\nthe\tO\nadverse\tO\ncardiovascular\tO\neffects\tO\nof\tO\nlithium\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\ncase\tO\n,\tO\ncomplete\tO\natrioventricular\tB-Disease\n(\tI-Disease\nAV\tI-Disease\n)\tI-Disease\nblock\tI-Disease\nwith\tO\nsyncopal\tB-Disease\nattacks\tI-Disease\ndeveloped\tO\nsecondary\tO\nto\tO\nlithium\tB-Chemical\ntherapy\tO\n,\tO\nnecessitating\tO\npermanent\tO\npacemaker\tO\nimplantation\tO\n.\tO\n\nSerum\tO\nlithium\tB-Chemical\nlevels\tO\nremained\tO\nunder\tO\nor\tO\nwithin\tO\nthe\tO\ntherapeutic\tO\nrange\tO\nduring\tO\nthe\tO\nsyncopal\tB-Disease\nattacks\tI-Disease\n.\tO\n\nLithium\tB-Chemical\nshould\tO\nbe\tO\nused\tO\nwith\tO\nextreme\tO\ncaution\tO\n,\tO\nespecially\tO\nin\tO\npatients\tO\nwith\tO\nmild\tO\ndisturbance\tO\nof\tO\nAV\tO\nconduction\tO\n.\tO\n\nExaggerated\tO\nexpression\tO\nof\tO\ninflammatory\tO\nmediators\tO\nin\tO\nvasoactive\tO\nintestinal\tO\npolypeptide\tO\nknockout\tO\n(\tO\nVIP\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nwith\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCYP\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncystitis\tB-Disease\n.\tO\n\nVasoactive\tO\nintestinal\tO\npolypeptide\tO\n(\tO\nVIP\tO\n)\tO\nis\tO\nan\tO\nimmunomodulatory\tO\nneuropeptide\tO\ndistributed\tO\nin\tO\nmicturition\tO\npathways\tO\n.\tO\n\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nexhibit\tO\naltered\tO\nbladder\tO\nfunction\tO\nand\tO\nneurochemical\tO\nproperties\tO\nin\tO\nmicturition\tO\npathways\tO\nafter\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCYP\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncystitis\tB-Disease\n.\tO\n\nGiven\tO\nVIP\tO\n'\tO\ns\tO\nrole\tO\nas\tO\nan\tO\nanti\tO\n-\tO\ninflammatory\tO\nmediator\tO\n,\tO\nwe\tO\nhypothesized\tO\nthat\tO\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nwould\tO\nexhibit\tO\nenhanced\tO\ninflammatory\tO\nmediator\tO\nexpression\tO\nafter\tO\ncystitis\tB-Disease\n.\tO\n\nA\tO\nmouse\tO\ninflammatory\tO\ncytokine\tO\nand\tO\nreceptor\tO\nRT2\tO\nprofiler\tO\narray\tO\nwas\tO\nused\tO\nto\tO\ndetermine\tO\nregulated\tO\ntranscripts\tO\nin\tO\nthe\tO\nurinary\tO\nbladder\tO\nof\tO\nwild\tO\ntype\tO\n(\tO\nWT\tO\n)\tO\nand\tO\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nwith\tO\nor\tO\nwithout\tO\nCYP\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\n(\tO\n150\tO\nmg\tO\n/\tO\nkg\tO\n;\tO\ni\tO\n.\tO\np\tO\n.\tO\n;\tO\n48\tO\nh\tO\n)\tO\n.\tO\n\nFour\tO\nbinary\tO\ncomparisons\tO\nwere\tO\nmade\tO\n:\tO\nWT\tO\ncontrol\tO\nversus\tO\nCYP\tB-Chemical\ntreatment\tO\n(\tO\n48\tO\nh\tO\n)\tO\n,\tO\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\ncontrol\tO\nversus\tO\nCYP\tB-Chemical\ntreatment\tO\n(\tO\n48\tO\nh\tO\n)\tO\n,\tO\nWT\tO\ncontrol\tO\nversus\tO\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\ncontrol\tO\n,\tO\nand\tO\nWT\tO\nwith\tO\nCYP\tB-Chemical\ntreatment\tO\n(\tO\n48\tO\nh\tO\n)\tO\nversus\tO\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nwith\tO\nCYP\tB-Chemical\ntreatment\tO\n(\tO\n48\tO\nh\tO\n)\tO\n.\tO\n\nThe\tO\ngenes\tO\npresented\tO\nrepresent\tO\n(\tO\n1\tO\n)\tO\ngreater\tO\nthan\tO\n1\tO\n.\tO\n5\tO\n-\tO\nfold\tO\nchange\tO\nin\tO\neither\tO\ndirection\tO\nand\tO\n(\tO\n2\tO\n)\tO\nthe\tO\np\tO\nvalue\tO\nis\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\nfor\tO\nthe\tO\ncomparison\tO\nbeing\tO\nmade\tO\n.\tO\n\nSeveral\tO\nregulated\tO\ngenes\tO\nwere\tO\nvalidated\tO\nusing\tO\nenzyme\tO\n-\tO\nlinked\tO\nimmunoassays\tO\nincluding\tO\nIL\tO\n-\tO\n1beta\tO\nand\tO\nCXCL1\tO\n.\tO\n\nCYP\tB-Chemical\ntreatment\tO\nsignificantly\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\nincreased\tO\nexpression\tO\nof\tO\nCXCL1\tO\nand\tO\nIL\tO\n-\tO\n1beta\tO\nin\tO\nthe\tO\nurinary\tO\nbladder\tO\nof\tO\nWT\tO\nand\tO\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n,\tO\nbut\tO\nexpression\tO\nin\tO\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nwith\tO\nCYP\tB-Chemical\ntreatment\tO\nwas\tO\nsignificantly\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\ngreater\tO\n(\tO\n4\tO\n.\tO\n2\tO\n-\tO\nto\tO\n13\tO\n-\tO\nfold\tO\nincrease\tO\n)\tO\nthan\tO\nthat\tO\nobserved\tO\nin\tO\nWT\tO\nurinary\tO\nbladder\tO\n(\tO\n3\tO\n.\tO\n6\tO\n-\tO\nto\tO\n5\tO\n-\tO\nfold\tO\nincrease\tO\n)\tO\n.\tO\n\nThe\tO\ndata\tO\nsuggest\tO\nthat\tO\nin\tO\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nwith\tO\nbladder\tB-Disease\ninflammation\tI-Disease\n,\tO\ninflammatory\tO\nmediators\tO\nare\tO\nincreased\tO\nabove\tO\nthat\tO\nobserved\tO\nin\tO\nWT\tO\nwith\tO\nCYP\tB-Chemical\n.\tO\n\nThis\tO\nshift\tO\nin\tO\nbalance\tO\nmay\tO\ncontribute\tO\nto\tO\nincreased\tO\nbladder\tB-Disease\ndysfunction\tI-Disease\nin\tO\nVIP\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nwith\tO\nbladder\tB-Disease\ninflammation\tI-Disease\nand\tO\naltered\tO\nneurochemical\tO\nexpression\tO\nin\tO\nmicturition\tO\npathways\tO\n.\tO\n\nDebrisoquine\tB-Chemical\nphenotype\tO\nand\tO\nthe\tO\npharmacokinetics\tO\nand\tO\nbeta\tO\n-\tO\n2\tO\nreceptor\tO\npharmacodynamics\tO\nof\tO\nmetoprolol\tB-Chemical\nand\tO\nits\tO\nenantiomers\tO\n.\tO\n\nThe\tO\nmetabolism\tO\nof\tO\nthe\tO\ncardioselective\tO\nbeta\tO\n-\tO\nblocker\tO\nmetoprolol\tB-Chemical\nis\tO\nunder\tO\ngenetic\tO\ncontrol\tO\nof\tO\nthe\tO\ndebrisoquine\tB-Chemical\n/\tO\nsparteine\tB-Chemical\ntype\tO\n.\tO\n\nThe\tO\ntwo\tO\nmetabolic\tO\nphenotypes\tO\n,\tO\nextensive\tO\n(\tO\nEM\tO\n)\tO\nand\tO\npoor\tO\nmetabolizers\tO\n(\tO\nPM\tO\n)\tO\n,\tO\nshow\tO\ndifferent\tO\nstereoselective\tO\nmetabolism\tO\n,\tO\nresulting\tO\nin\tO\napparently\tO\nhigher\tO\nbeta\tO\n-\tO\n1\tO\nadrenoceptor\tO\nantagonistic\tO\npotency\tO\nof\tO\nracemic\tO\nmetoprolol\tB-Chemical\nin\tO\nEMs\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nif\tO\nthe\tO\nlatter\tO\nalso\tO\napplies\tO\nto\tO\nthe\tO\nbeta\tO\n-\tO\n2\tO\nadrenoceptor\tO\nantagonism\tO\nby\tO\nmetoprolol\tB-Chemical\n.\tO\n\nThe\tO\ndrug\tO\neffect\tO\nstudied\tO\nwas\tO\nthe\tO\nantagonism\tO\nby\tO\nmetoprolol\tB-Chemical\nof\tO\nterbutaline\tB-Chemical\n-\tO\ninduced\tO\nhypokalemia\tB-Disease\n.\tO\n\nBy\tO\nusing\tO\npharmacokinetic\tO\npharmacodynamic\tO\nmodeling\tO\nthe\tO\npharmacodynamics\tO\nof\tO\nracemic\tO\nmetoprolol\tB-Chemical\nand\tO\nthe\tO\nactive\tO\nS\tO\n-\tO\nisomer\tO\n,\tO\nwere\tO\nquantitated\tO\nin\tO\nEMs\tO\nand\tO\nPMs\tO\nin\tO\nterms\tO\nof\tO\nIC50\tO\nvalues\tO\n,\tO\nrepresenting\tO\nmetoprolol\tB-Chemical\nplasma\tO\nconcentrations\tO\nresulting\tO\nin\tO\nhalf\tO\n-\tO\nmaximum\tO\nreceptor\tO\noccupancy\tO\n.\tO\n\nSix\tO\nEMs\tO\nreceived\tO\n0\tO\n.\tO\n5\tO\nmg\tO\nof\tO\nterbutaline\tB-Chemical\ns\tO\n.\tO\nc\tO\n.\tO\non\tO\ntwo\tO\ndifferent\tO\noccasions\tO\n:\tO\n1\tO\n)\tO\n1\tO\nhr\tO\nafter\tO\nadministration\tO\nof\tO\na\tO\nplacebo\tO\nand\tO\n2\tO\n)\tO\n1\tO\nhr\tO\nafter\tO\n150\tO\nmg\tO\nof\tO\nmetoprolol\tB-Chemical\np\tO\n.\tO\no\tO\n.\tO\n\nFive\tO\nPMs\tO\nwere\tO\nstudied\tO\naccording\tO\nto\tO\nthe\tO\nsame\tO\nprotocol\tO\n,\tO\nexcept\tO\nfor\tO\na\tO\nhigher\tO\nterbutaline\tB-Chemical\ndose\tO\n(\tO\n0\tO\n.\tO\n75\tO\nmg\tO\n)\tO\non\tO\nday\tO\n2\tO\n.\tO\n\nBlood\tO\nsamples\tO\nfor\tO\nthe\tO\nanalysis\tO\nof\tO\nplasma\tO\npotassium\tB-Chemical\n,\tO\nterbutaline\tB-Chemical\n,\tO\nmetoprolol\tB-Chemical\n(\tO\nracemic\tO\n,\tO\nR\tO\n-\tO\nand\tO\nS\tO\n-\tO\nisomer\tO\n)\tO\n,\tO\nand\tO\nalpha\tB-Chemical\n-\tI-Chemical\nhydroxymetoprolol\tI-Chemical\nconcentrations\tO\nwere\tO\ntaken\tO\nat\tO\nregular\tO\ntime\tO\nintervals\tO\n,\tO\nduring\tO\n8\tO\nhr\tO\nafter\tO\nmetoprolol\tB-Chemical\n.\tO\n\nIn\tO\nPMs\tO\n,\tO\nmetoprolol\tB-Chemical\nincreased\tO\nthe\tO\nterbutaline\tB-Chemical\narea\tO\nunder\tO\nthe\tO\nplasma\tO\nconcentration\tO\nvs\tO\n.\tO\ntime\tO\ncurve\tO\n(\tO\n+\tO\n67\tO\n%\tO\n)\tO\n.\tO\n\nHigher\tO\nmetoprolol\tB-Chemical\n/\tO\nalpha\tB-Chemical\n-\tI-Chemical\nhydroxymetoprolol\tI-Chemical\nratios\tO\nin\tO\nPMs\tO\nwere\tO\npredictive\tO\nfor\tO\nhigher\tO\nR\tO\n-\tO\n/\tO\nS\tO\n-\tO\nisomer\tO\nratios\tO\nof\tO\nunchanged\tO\ndrug\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\ndifference\tO\nin\tO\nmetoprolol\tB-Chemical\npotency\tO\nwith\tO\nhigher\tO\nracemic\tO\nmetoprolol\tB-Chemical\nIC50\tO\nvalues\tO\nin\tO\nPMs\tO\n(\tO\n72\tO\n+\tO\n/\tO\n-\tO\n7\tO\nng\tO\n.\tO\nml\tO\n-\tO\n1\tO\n)\tO\nthan\tO\nEMs\tO\n(\tO\n42\tO\n+\tO\n/\tO\n-\tO\n8\tO\nng\tO\n.\tO\nml\tO\n-\tO\n1\tO\n,\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n001\tO\n)\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nThe\tO\nhemodynamics\tO\nof\tO\noxytocin\tB-Chemical\nand\tO\nother\tO\nvasoactive\tO\nagents\tO\nduring\tO\nneuraxial\tO\nanesthesia\tO\nfor\tO\ncesarean\tO\ndelivery\tO\n:\tO\nfindings\tO\nin\tO\nsix\tO\ncases\tO\n.\tO\n\nOxytocin\tB-Chemical\nis\tO\na\tO\ncommonly\tO\nused\tO\nuterotonic\tO\nthat\tO\ncan\tO\ncause\tO\nsignificant\tO\nand\tO\neven\tO\nfatal\tO\nhypotension\tB-Disease\n,\tO\nparticularly\tO\nwhen\tO\ngiven\tO\nas\tO\na\tO\nbolus\tO\n.\tO\n\nThe\tO\nresulting\tO\nhypotension\tB-Disease\ncan\tO\nbe\tO\nproduced\tO\nby\tO\na\tO\ndecrease\tO\nin\tO\nsystemic\tO\nvascular\tO\nresistance\tO\nor\tO\ncardiac\tO\noutput\tO\nthrough\tO\na\tO\ndecrease\tO\nin\tO\nvenous\tO\nreturn\tO\n.\tO\n\nParturients\tO\nwith\tO\nnormal\tO\nvolume\tO\nstatus\tO\n,\tO\nheart\tO\nvalves\tO\nand\tO\npulmonary\tO\nvasculature\tO\nmost\tO\noften\tO\nrespond\tO\nto\tO\nthis\tO\nhypotension\tB-Disease\nwith\tO\na\tO\ncompensatory\tO\nincrease\tO\nin\tO\nheart\tO\nrate\tO\nand\tO\nstroke\tB-Disease\nvolume\tO\n.\tO\n\nOxytocin\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nat\tO\ncesarean\tO\ndelivery\tO\nmay\tO\nbe\tO\nincorrectly\tO\nattributed\tO\nto\tO\nblood\tB-Disease\nloss\tI-Disease\n.\tO\n\nPulse\tO\npower\tO\nanalysis\tO\n(\tO\nalso\tO\ncalled\tO\n\"\tO\npulse\tO\ncontour\tO\nanalysis\tO\n\"\tO\n)\tO\nof\tO\nan\tO\narterial\tO\npressure\tO\nwave\tO\nform\tO\nallows\tO\ncontinuous\tO\nevaluation\tO\nof\tO\nsystemic\tO\nvascular\tO\nresistance\tO\nand\tO\ncardiac\tO\noutput\tO\nin\tO\nreal\tO\ntime\tO\n,\tO\nthereby\tO\nelucidating\tO\nthe\tO\ncausative\tO\nfactors\tO\nbehind\tO\nchanges\tO\nin\tO\nblood\tO\npressure\tO\n.\tO\n\nPulse\tO\npower\tO\nanalysis\tO\nwas\tO\nconducted\tO\nin\tO\nsix\tO\ncases\tO\nof\tO\ncesarean\tO\ndelivery\tO\nperformed\tO\nunder\tO\nneuraxial\tO\nanesthesia\tO\n.\tO\n\nHypotension\tB-Disease\nin\tO\nresponse\tO\nto\tO\noxytocin\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\nsystemic\tO\nvascular\tO\nresistance\tO\nand\tO\na\tO\ncompensatory\tO\nincrease\tO\nin\tO\nstroke\tB-Disease\nvolume\tO\n,\tO\nheart\tO\nrate\tO\nand\tO\ncardiac\tO\noutput\tO\n.\tO\n\nPulse\tO\npower\tO\nanalysis\tO\nmay\tO\nbe\tO\nhelpful\tO\nin\tO\ndetermining\tO\nthe\tO\netiology\tO\nof\tO\nand\tO\ntreating\tO\nhypotension\tB-Disease\nduring\tO\ncesarean\tO\ndelivery\tO\nunder\tO\nneuraxial\tO\nanesthesia\tO\n.\tO\n\nProtective\tO\neffects\tO\nof\tO\nantithrombin\tO\non\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nnephrosis\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\neffects\tO\nof\tO\nantithrombin\tO\n,\tO\na\tO\nplasma\tO\ninhibitor\tO\nof\tO\ncoagulation\tO\nfactors\tO\n,\tO\nin\tO\nrats\tO\nwith\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nnephrosis\tB-Disease\n,\tO\nwhich\tO\nis\tO\nan\tO\nexperimental\tO\nmodel\tO\nof\tO\nhuman\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nAntithrombin\tO\n(\tO\n50\tO\nor\tO\n500\tO\nIU\tO\n/\tO\nkg\tO\n/\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nwas\tO\nadministered\tO\nto\tO\nrats\tO\nonce\tO\na\tO\nday\tO\nfor\tO\n10\tO\ndays\tO\nimmediately\tO\nafter\tO\nthe\tO\ninjection\tO\nof\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\n.\tO\n\nTreatment\tO\nwith\tO\nantithrombin\tO\nattenuated\tO\nthe\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nhematological\tB-Disease\nabnormalities\tI-Disease\n.\tO\n\nPuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\nand\tO\nhyperlipidemia\tB-Disease\nwere\tO\nalso\tO\nsuppressed\tO\n.\tO\n\nHistopathological\tO\nexamination\tO\nrevealed\tO\nsevere\tO\nrenal\tB-Disease\ndamage\tI-Disease\nsuch\tO\nas\tO\nproteinaceous\tO\ncasts\tO\nin\tO\ntubuli\tO\nand\tO\ntubular\tO\nexpansion\tO\nin\tO\nthe\tO\nkidney\tO\nof\tO\ncontrol\tO\nrats\tO\n,\tO\nwhile\tO\nan\tO\nimprovement\tO\nof\tO\nthe\tO\ndamage\tO\nwas\tO\nseen\tO\nin\tO\nantithrombin\tO\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nantithrombin\tO\ntreatment\tO\nmarkedly\tO\nsuppressed\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\napoptosis\tO\nof\tO\nrenal\tO\ntubular\tO\nepithelial\tO\ncells\tO\n.\tO\n\nFurthermore\tO\n,\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nrenal\tO\ncytokine\tO\ncontent\tO\nwere\tO\nalso\tO\ndecreased\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nthrombin\tO\nplays\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nTreatment\tO\nwith\tO\nantithrombin\tO\nmay\tO\nbe\tO\nclinically\tO\neffective\tO\nin\tO\npatients\tO\nwith\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nHeparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nafter\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nUnfractionated\tB-Chemical\nheparin\tI-Chemical\nsodium\tI-Chemical\n(\tO\nUFH\tB-Chemical\n)\tO\nor\tO\nlow\tB-Chemical\n-\tI-Chemical\nmolecular\tI-Chemical\nweight\tI-Chemical\nheparin\tI-Chemical\n(\tO\nLMWH\tO\n)\tO\nis\tO\nused\tO\nin\tO\nanticoagulant\tO\nprotocols\tO\nat\tO\nseveral\tO\ninstitutions\tO\nto\tO\nprevent\tO\nthrombosis\tB-Disease\nafter\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nHeparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n(\tO\nHIT\tB-Disease\n)\tO\nis\tO\nan\tO\nadverse\tO\nimmune\tO\n-\tO\nmediated\tO\nreaction\tO\nto\tO\nheparin\tB-Chemical\n,\tO\nresulting\tO\nin\tO\nplatelet\tO\ncount\tO\ndecreases\tO\nof\tO\nmore\tO\nthan\tO\n50\tO\n%\tO\n.\tO\n\nThe\tO\nfrequencies\tO\nof\tO\nHIT\tB-Disease\nafter\tO\nliver\tO\ntransplantation\tO\nand\tO\nplatelet\tO\nfactor\tO\n4\tO\n/\tO\nheparin\tB-Chemical\n-\tO\nreactive\tO\nantibody\tO\n(\tO\nHIT\tB-Disease\nantibody\tO\n)\tO\npositivity\tO\nin\tO\nliver\tO\ntransplantation\tO\npatients\tO\n,\tO\nhowever\tO\n,\tO\nare\tO\nunknown\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nThe\tO\n32\tO\nmen\tO\nand\tO\n20\tO\nwomen\tO\nunderwent\tO\nliving\tO\ndonor\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nWe\tO\nstarted\tO\nLMWH\tO\n(\tO\n25\tO\nIU\tO\n/\tO\nkg\tO\n/\tO\nh\tO\n)\tO\non\tO\npostoperative\tO\nday\tO\n(\tO\nPOD\tO\n)\tO\n1\tO\n,\tO\nswitching\tO\nto\tO\nUFH\tB-Chemical\n(\tO\n5000\tO\nU\tO\n/\tO\nd\tO\n)\tO\non\tO\nPOD\tO\n2\tO\nor\tO\n3\tO\n.\tO\n\nThe\tO\ndose\tO\nof\tO\nUFH\tB-Chemical\nwas\tO\nchanged\tO\naccording\tO\nto\tO\nthe\tO\nactivated\tO\nclotting\tO\ntime\tO\nlevel\tO\n.\tO\n\nHIT\tB-Disease\nantibody\tO\nlevels\tO\nwere\tO\nmeasured\tO\nthe\tO\nday\tO\nbefore\tO\nsurgery\tO\nand\tO\non\tO\nPOD\tO\n7\tO\nand\tO\n14\tO\n.\tO\n\nPlatelet\tO\ncount\tO\nwas\tO\nmeasured\tO\ndaily\tO\nfor\tO\n3\tO\nweeks\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\naverage\tO\nplatelet\tO\ncounts\tO\npreoperatively\tO\n,\tO\nand\tO\non\tO\nPOD\tO\n7\tO\n,\tO\n14\tO\n,\tO\nand\tO\n21\tO\nwere\tO\n65\tO\n,\tO\n88\tO\n,\tO\n149\tO\n,\tO\nand\tO\n169\tO\nx\tO\n10\tO\n(\tO\n9\tO\n)\tO\n/\tO\nL\tO\n,\tO\nrespectively\tO\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\nhepatic\tO\nartery\tO\nthrombosis\tB-Disease\non\tO\nPOD\tO\n11\tO\nand\tO\n19\tO\n,\tO\nrespectively\tO\n,\tO\nalthough\tO\nthey\tO\nwere\tO\nHIT\tB-Disease\nantibody\tO\n-\tO\nnegative\tO\nand\tO\ntheir\tO\nplatelet\tO\ncounts\tO\nwere\tO\nstable\tO\n.\tO\n\nIn\tO\n2\tO\nother\tO\npatients\tO\n,\tO\nthe\tO\nplatelet\tO\ncount\tO\ndecreased\tO\nsuddenly\tO\nfrom\tO\n107\tO\nx\tO\n10\tO\n(\tO\n9\tO\n)\tO\n/\tO\nL\tO\non\tO\nPOD\tO\n4\tO\nto\tO\n65\tO\nx\tO\n10\tO\n(\tO\n9\tO\n)\tO\n/\tO\nL\tO\non\tO\nPOD\tO\n6\tO\nand\tO\nfrom\tO\n76\tO\nx\tO\n10\tO\n(\tO\n9\tO\n)\tO\n/\tO\nL\tO\non\tO\nPOD\tO\n7\tO\nto\tO\n33\tO\nx\tO\n10\tO\n(\tO\n9\tO\n)\tO\n/\tO\nL\tO\non\tO\nPOD\tO\n9\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nplatelet\tB-Disease\naggregation\tI-Disease\ntest\tO\nwas\tO\nnegative\tO\nin\tO\nthese\tO\npatients\tO\n.\tO\n\nThe\tO\npercentage\tO\nof\tO\nHIT\tB-Disease\nantibody\tO\n-\tO\npositive\tO\npatients\tO\nwas\tO\n0\tO\n.\tO\n5\tO\n%\tO\npreoperatively\tO\n,\tO\n5\tO\n.\tO\n6\tO\n%\tO\non\tO\nPOD\tO\n7\tO\n,\tO\nand\tO\n5\tO\n.\tO\n6\tO\n%\tO\non\tO\nPOD\tO\n14\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\nsubjects\tO\n/\tO\npatients\tO\ndeveloped\tO\nUFH\tB-Chemical\n-\tO\nrelated\tO\nHIT\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\nour\tO\nseries\tO\n,\tO\nthe\tO\noccurrence\tO\nof\tO\nHIT\tB-Disease\nafter\tO\nliver\tO\ntransplantation\tO\nwas\tO\nuncommon\tO\n.\tO\n\nDoxorubicin\tB-Chemical\ncardiomyopathy\tB-Disease\n-\tO\ninduced\tO\ninflammation\tB-Disease\nand\tO\napoptosis\tO\nare\tO\nattenuated\tO\nby\tO\ngene\tO\ndeletion\tO\nof\tO\nthe\tO\nkinin\tO\nB1\tO\nreceptor\tO\n.\tO\n\nClinical\tO\nuse\tO\nof\tO\nthe\tO\nanthracycline\tB-Chemical\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\nis\tO\nlimited\tO\nby\tO\nits\tO\ncardiotoxic\tB-Disease\neffects\tO\n,\tO\nwhich\tO\nare\tO\nattributed\tO\nto\tO\nthe\tO\ninduction\tO\nof\tO\napoptosis\tO\n.\tO\n\nTo\tO\nelucidate\tO\nthe\tO\npossible\tO\nrole\tO\nof\tO\nthe\tO\nkinin\tO\nB1\tO\nreceptor\tO\n(\tO\nB1R\tO\n)\tO\nduring\tO\nthe\tO\ndevelopment\tO\nof\tO\nDOX\tB-Chemical\ncardiomyopathy\tB-Disease\n,\tO\nwe\tO\nstudied\tO\nB1R\tO\nknockout\tO\nmice\tO\n(\tO\nB1R\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\n)\tO\nby\tO\ninvestigating\tO\ncardiac\tO\ninflammation\tB-Disease\nand\tO\napoptosis\tO\nafter\tO\ninduction\tO\nof\tO\nDOX\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\n.\tO\n\nDOX\tB-Chemical\ncontrol\tO\nmice\tO\nshowed\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\nmeasured\tO\nby\tO\npressure\tO\n-\tO\nvolume\tO\nloops\tO\nin\tO\nvivo\tO\n.\tO\n\nThis\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nreduced\tO\nactivation\tO\nstate\tO\nof\tO\nAKT\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nan\tO\nincreased\tO\nbax\tO\n/\tO\nbcl2\tO\nratio\tO\nin\tO\nWestern\tO\nblots\tO\n,\tO\nindicating\tO\ncardiac\tB-Disease\napoptosis\tI-Disease\n.\tO\n\nFurthermore\tO\n,\tO\nmRNA\tO\nlevels\tO\nof\tO\nthe\tO\nproinflammatory\tO\ncytokine\tO\ninterleukin\tO\n6\tO\nwere\tO\nincreased\tO\nin\tO\nthe\tO\ncardiac\tO\ntissue\tO\n.\tO\n\nIn\tO\nDOX\tB-Chemical\nB1R\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n,\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\nwas\tO\nimproved\tO\ncompared\tO\nto\tO\nDOX\tB-Chemical\ncontrol\tO\nmice\tO\n,\tO\nwhich\tO\nwas\tO\nassociated\tO\nwith\tO\nnormalization\tO\nof\tO\nthe\tO\nbax\tO\n/\tO\nbcl\tO\n-\tO\n2\tO\nratio\tO\nand\tO\ninterleukin\tO\n6\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nAKT\tO\nactivation\tO\nstate\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nB1R\tO\nis\tO\ndetrimental\tO\nin\tO\nDOX\tB-Chemical\ncardiomyopathy\tB-Disease\nin\tO\nthat\tO\nit\tO\nmediates\tO\nthe\tO\ninflammatory\tO\nresponse\tO\nand\tO\napoptosis\tO\n.\tO\n\nThese\tO\ninsights\tO\nmight\tO\nhave\tO\nuseful\tO\nimplications\tO\nfor\tO\nfuture\tO\nstudies\tO\nutilizing\tO\nB1R\tO\nantagonists\tO\nfor\tO\ntreatment\tO\nof\tO\nhuman\tO\nDOX\tB-Chemical\ncardiomyopathy\tB-Disease\n.\tO\n\nDetailed\tO\nspectral\tO\nprofile\tO\nanalysis\tO\nof\tO\npenicillin\tB-Chemical\n-\tO\ninduced\tO\nepileptiform\tB-Disease\nactivity\tI-Disease\nin\tO\nanesthetized\tO\nrats\tO\n.\tO\n\nPenicillin\tB-Chemical\nmodel\tO\nis\tO\na\tO\nwidely\tO\nused\tO\nexperimental\tO\nmodel\tO\nfor\tO\nepilepsy\tB-Disease\nresearch\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\nwe\tO\naimed\tO\nto\tO\nportray\tO\na\tO\ndetailed\tO\nspectral\tO\nanalysis\tO\nof\tO\npenicillin\tB-Chemical\n-\tO\ninduced\tO\nepileptiform\tB-Disease\nactivity\tI-Disease\nin\tO\ncomparison\tO\nwith\tO\nbasal\tO\nbrain\tO\nactivity\tO\nin\tO\nanesthetized\tO\nWistar\tO\nrats\tO\n.\tO\n\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\nanesthetized\tO\nwith\tO\ni\tO\n.\tO\np\tO\n.\tO\nurethane\tB-Chemical\nand\tO\nconnected\tO\nto\tO\nan\tO\nelectrocorticogram\tO\nsetup\tO\n.\tO\n\nAfter\tO\na\tO\nshort\tO\nperiod\tO\nof\tO\nbasal\tO\nactivity\tO\nrecording\tO\n,\tO\nepileptic\tB-Disease\nfocus\tO\nwas\tO\ninduced\tO\nby\tO\ninjecting\tO\n400IU\tO\n/\tO\n2\tO\nmicrol\tO\npenicillin\tB-Chemical\n-\tI-Chemical\nG\tI-Chemical\npotassium\tI-Chemical\ninto\tO\nthe\tO\nleft\tO\nlateral\tO\nventricle\tO\nwhile\tO\nthe\tO\ncortical\tO\nactivity\tO\nwas\tO\ncontinuously\tO\nrecorded\tO\n.\tO\n\nBasal\tO\nactivity\tO\n,\tO\nlatent\tO\nperiod\tO\nand\tO\nthe\tO\npenicillin\tB-Chemical\n-\tO\ninduced\tO\nepileptiform\tB-Disease\nactivity\tI-Disease\nperiods\tO\nwere\tO\nthen\tO\nanalyzed\tO\nusing\tO\nboth\tO\nconventional\tO\nmethods\tO\nand\tO\nspectral\tO\nanalysis\tO\n.\tO\n\nSpectral\tO\nanalyses\tO\nwere\tO\nconducted\tO\nby\tO\ndividing\tO\nthe\tO\nwhole\tO\nspectrum\tO\ninto\tO\ndifferent\tO\nfrequency\tO\nbands\tO\nincluding\tO\ndelta\tO\n,\tO\ntheta\tO\n(\tO\nslow\tO\nand\tO\nfast\tO\n)\tO\n,\tO\nalpha\tO\n-\tO\nsigma\tO\n,\tO\nbeta\tO\n(\tO\n1\tO\nand\tO\n2\tO\n)\tO\nand\tO\ngamma\tO\n(\tO\n1\tO\nand\tO\n2\tO\n)\tO\nbands\tO\n.\tO\n\nOur\tO\nresults\tO\nshow\tO\nthat\tO\nthe\tO\nmost\tO\naffected\tO\nfrequency\tO\nbands\tO\nwere\tO\ndelta\tO\n,\tO\ntheta\tO\n,\tO\nbeta\tO\n-\tO\n2\tO\nand\tO\ngamma\tO\n-\tO\n2\tO\nbands\tO\nduring\tO\nthe\tO\nepileptiform\tB-Disease\nactivity\tI-Disease\nand\tO\nthere\tO\nwere\tO\nmarked\tO\ndifferences\tO\nin\tO\nterms\tO\nof\tO\nspectral\tO\ndensities\tO\nbetween\tO\nthree\tO\ninvestigated\tO\nepisodes\tO\n(\tO\nbasal\tO\nactivity\tO\n,\tO\nlatent\tO\nperiod\tO\nand\tO\nepileptiform\tB-Disease\nactivity\tI-Disease\n)\tO\n.\tO\n\nOur\tO\nresults\tO\nmay\tO\nhelp\tO\nto\tO\nanalyze\tO\nnovel\tO\ndata\tO\nobtained\tO\nusing\tO\nsimilar\tO\nexperimental\tO\nmodels\tO\nand\tO\nthe\tO\nsimple\tO\nanalysis\tO\nmethod\tO\ndescribed\tO\nhere\tO\ncan\tO\nbe\tO\nused\tO\nin\tO\nsimilar\tO\nstudies\tO\nto\tO\ninvestigate\tO\nthe\tO\nbasic\tO\nneuronal\tO\nmechanism\tO\nof\tO\nthis\tO\nor\tO\nother\tO\ntypes\tO\nof\tO\nexperimental\tO\nepilepsies\tB-Disease\n.\tO\n\nHigh\tO\nfat\tB-Chemical\ndiet\tO\n-\tO\nfed\tO\nobese\tB-Disease\nrats\tO\nare\tO\nhighly\tO\nsensitive\tO\nto\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nOften\tO\n,\tO\nchemotherapy\tO\nby\tO\ndoxorubicin\tB-Chemical\n(\tO\nAdriamycin\tB-Chemical\n)\tO\nis\tO\nlimited\tO\ndue\tO\nto\tO\nlife\tO\nthreatening\tO\ncardiotoxicity\tB-Disease\nin\tO\npatients\tO\nduring\tO\nand\tO\nposttherapy\tO\n.\tO\n\nRecently\tO\n,\tO\nwe\tO\nhave\tO\nshown\tO\nthat\tO\nmoderate\tO\ndiet\tO\nrestriction\tO\nremarkably\tO\nprotects\tO\nagainst\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nThis\tO\ncardioprotection\tO\nis\tO\naccompanied\tO\nby\tO\ndecreased\tO\ncardiac\tO\noxidative\tO\nstress\tO\nand\tO\ntriglycerides\tB-Chemical\nand\tO\nincreased\tO\ncardiac\tO\nfatty\tO\n-\tO\nacid\tO\noxidation\tO\n,\tO\nATP\tB-Chemical\nsynthesis\tO\n,\tO\nand\tO\nupregulated\tO\nJAK\tO\n/\tO\nSTAT3\tO\npathway\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nwhether\tO\na\tO\nphysiological\tO\nintervention\tO\nby\tO\nfeeding\tO\n40\tO\n%\tO\nhigh\tO\nfat\tB-Chemical\ndiet\tO\n(\tO\nHFD\tO\n)\tO\n,\tO\nwhich\tO\ninduces\tO\nobesity\tB-Disease\nin\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\n(\tO\n250\tO\n-\tO\n275\tO\ng\tO\n)\tO\n,\tO\nsensitizes\tO\nto\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nA\tO\nLD\tO\n(\tO\n10\tO\n)\tO\ndose\tO\n(\tO\n8\tO\nmg\tO\ndoxorubicin\tB-Chemical\n/\tO\nkg\tO\n,\tO\nip\tO\n)\tO\nadministered\tO\non\tO\nday\tO\n43\tO\nof\tO\nthe\tO\nHFD\tO\nfeeding\tO\nregimen\tO\nled\tO\nto\tO\nhigher\tO\ncardiotoxicity\tB-Disease\n,\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\n,\tO\nlipid\tO\nperoxidation\tO\n,\tO\nand\tO\n80\tO\n%\tO\nmortality\tO\nin\tO\nthe\tO\nobese\tB-Disease\n(\tO\nOB\tB-Disease\n)\tO\nrats\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nany\tO\nsignificant\tO\nrenal\tB-Disease\nor\tI-Disease\nhepatic\tI-Disease\ntoxicity\tI-Disease\n.\tO\n\nDoxorubicin\tB-Chemical\ntoxicokinetics\tO\nstudies\tO\nrevealed\tO\nno\tO\nchange\tO\nin\tO\naccumulation\tO\nof\tO\ndoxorubicin\tB-Chemical\nand\tO\ndoxorubicinol\tB-Chemical\n(\tO\ntoxic\tO\nmetabolite\tO\n)\tO\nin\tO\nthe\tO\nnormal\tO\ndiet\tO\n-\tO\nfed\tO\n(\tO\nND\tO\n)\tO\nand\tO\nOB\tB-Disease\nhearts\tO\n.\tO\n\nMechanistic\tO\nstudies\tO\nrevealed\tO\nthat\tO\nOB\tB-Disease\nrats\tO\nare\tO\nsensitized\tO\ndue\tO\nto\tO\n:\tO\n(\tO\n1\tO\n)\tO\nhigher\tO\noxyradical\tO\nstress\tO\nleading\tO\nto\tO\nupregulation\tO\nof\tO\nuncoupling\tO\nproteins\tO\n2\tO\nand\tO\n3\tO\n,\tO\n(\tO\n2\tO\n)\tO\ndownregulation\tO\nof\tO\ncardiac\tO\nperoxisome\tO\nproliferators\tO\nactivated\tO\nreceptor\tO\n-\tO\nalpha\tO\n,\tO\n(\tO\n3\tO\n)\tO\ndecreased\tO\nplasma\tO\nadiponectin\tO\nlevels\tO\n,\tO\n(\tO\n4\tO\n)\tO\ndecreased\tO\ncardiac\tO\nfatty\tO\n-\tO\nacid\tO\noxidation\tO\n(\tO\n666\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n14\tO\n.\tO\n0\tO\nnmol\tO\n/\tO\nmin\tO\n/\tO\ng\tO\nheart\tO\nin\tO\nND\tO\nversus\tO\n400\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n11\tO\n.\tO\n8\tO\nnmol\tO\n/\tO\nmin\tO\n/\tO\ng\tO\nheart\tO\nin\tO\nOB\tB-Disease\n)\tO\n,\tO\n(\tO\n5\tO\n)\tO\ndecreased\tO\nmitochondrial\tO\nAMP\tB-Chemical\n-\tO\nalpha2\tO\nprotein\tO\nkinase\tO\n,\tO\nand\tO\n(\tO\n6\tO\n)\tO\n86\tO\n%\tO\ndrop\tO\nin\tO\ncardiac\tO\nATP\tB-Chemical\nlevels\tO\naccompanied\tO\nby\tO\ndecreased\tO\nATP\tB-Chemical\n/\tO\nADP\tB-Chemical\nratio\tO\nafter\tO\ndoxorubicin\tB-Chemical\nadministration\tO\n.\tO\n\nDecreased\tO\ncardiac\tO\nerythropoietin\tO\nand\tO\nincreased\tO\nSOCS3\tO\nfurther\tO\ndownregulated\tO\nthe\tO\ncardioprotective\tO\nJAK\tO\n/\tO\nSTAT3\tO\npathway\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nHFD\tO\n-\tO\ninduced\tO\nobese\tB-Disease\nrats\tO\nare\tO\nhighly\tO\nsensitized\tO\nto\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nby\tO\nsubstantially\tO\ndownregulating\tO\ncardiac\tO\nmitochondrial\tO\nATP\tB-Chemical\ngeneration\tO\n,\tO\nincreasing\tO\noxidative\tO\nstress\tO\nand\tO\ndownregulating\tO\nthe\tO\nJAK\tO\n/\tO\nSTAT3\tO\npathway\tO\n.\tO\n\nIsoproterenol\tB-Chemical\ninduces\tO\nprimary\tO\nloss\tO\nof\tO\ndystrophin\tO\nin\tO\nrat\tO\nhearts\tO\n:\tO\ncorrelation\tO\nwith\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nis\tO\nunknown\tO\n,\tO\nbut\tO\na\tO\nmismatch\tO\nof\tO\noxygen\tB-Chemical\nsupply\tO\nvs\tO\n.\tO\ndemand\tO\nfollowing\tO\ncoronary\tO\nhypotension\tB-Disease\nand\tO\nmyocardial\tB-Disease\nhyperactivity\tI-Disease\nis\tO\nthe\tO\nbest\tO\nexplanation\tO\nfor\tO\nthe\tO\ncomplex\tO\nmorphological\tO\nalterations\tO\nobserved\tO\n.\tO\n\nSevere\tO\nalterations\tO\nin\tO\nthe\tO\nstructural\tO\nintegrity\tO\nof\tO\nthe\tO\nsarcolemma\tO\nof\tO\ncardiomyocytes\tO\nhave\tO\nbeen\tO\ndemonstrated\tO\nto\tO\nbe\tO\ncaused\tO\nby\tO\nisoproterenol\tB-Chemical\n.\tO\n\nTaking\tO\ninto\tO\naccount\tO\nthat\tO\nthe\tO\nsarcolemmal\tO\nintegrity\tO\nis\tO\nstabilized\tO\nby\tO\nthe\tO\ndystrophin\tO\n-\tO\nglycoprotein\tO\ncomplex\tO\n(\tO\nDGC\tO\n)\tO\nthat\tO\nconnects\tO\nactin\tO\nand\tO\nlaminin\tO\nin\tO\ncontractile\tO\nmachinery\tO\nand\tO\nextracellular\tO\nmatrix\tO\nand\tO\nby\tO\nintegrins\tO\n,\tO\nthis\tO\nstudy\tO\ntests\tO\nthe\tO\nhypothesis\tO\nthat\tO\nisoproterenol\tB-Chemical\naffects\tO\nsarcolemmal\tO\nstability\tO\nthrough\tO\nchanges\tO\nin\tO\nthe\tO\nDGC\tO\nand\tO\nintegrins\tO\n.\tO\n\nWe\tO\nfound\tO\ndifferent\tO\nsensitivity\tO\nof\tO\nthe\tO\nDGC\tO\nand\tO\nintegrin\tO\nto\tO\nisoproterenol\tB-Chemical\nsubcutaneous\tO\nadministration\tO\n.\tO\n\nImmunofluorescent\tO\nstaining\tO\nrevealed\tO\nthat\tO\ndystrophin\tO\nis\tO\nthe\tO\nmost\tO\nsensitive\tO\namong\tO\nthe\tO\nstructures\tO\nconnecting\tO\nthe\tO\nactin\tO\nin\tO\nthe\tO\ncardiomyocyte\tO\ncytoskeleton\tO\nand\tO\nthe\tO\nextracellular\tO\nmatrix\tO\n.\tO\n\nThe\tO\nsarcomeric\tO\nactin\tO\ndissolution\tO\noccurred\tO\nafter\tO\nthe\tO\nreduction\tO\nor\tO\nloss\tO\nof\tO\ndystrophin\tO\n.\tO\n\nSubsequently\tO\n,\tO\nafter\tO\nlysis\tO\nof\tO\nmyofilaments\tO\n,\tO\ngamma\tO\n-\tO\nsarcoglycan\tO\n,\tO\nbeta\tO\n-\tO\ndystroglycan\tO\n,\tO\nbeta1\tO\n-\tO\nintegrin\tO\n,\tO\nand\tO\nlaminin\tO\nalpha\tO\n-\tO\n2\tO\nexpressions\tO\nwere\tO\nreduced\tO\nfollowed\tO\nby\tO\ntheir\tO\nbreakdown\tO\n,\tO\nas\tO\nepiphenomena\tO\nof\tO\nthe\tO\nmyocytolytic\tO\nprocess\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nadministration\tO\nof\tO\nisoproterenol\tB-Chemical\nto\tO\nrats\tO\nresults\tO\nin\tO\nprimary\tO\nloss\tO\nof\tO\ndystrophin\tO\n,\tO\nthe\tO\nmost\tO\nsensitive\tO\namong\tO\nthe\tO\nstructural\tO\nproteins\tO\nthat\tO\nform\tO\nthe\tO\nDGC\tO\nthat\tO\nconnects\tO\nthe\tO\nextracellular\tO\nmatrix\tO\nand\tO\nthe\tO\ncytoskeleton\tO\nin\tO\ncardiomyocyte\tO\n.\tO\n\nThese\tO\nchanges\tO\n,\tO\nrelated\tO\nto\tO\nischaemic\tB-Disease\ninjury\tI-Disease\n,\tO\nexplain\tO\nthe\tO\nsevere\tO\nalterations\tO\nin\tO\nthe\tO\nstructural\tO\nintegrity\tO\nof\tO\nthe\tO\nsarcolemma\tO\nof\tO\ncardiomyocytes\tO\nand\tO\nhence\tO\nsevere\tO\nand\tO\nirreversible\tO\ninjury\tO\ninduced\tO\nby\tO\nisoproterenol\tB-Chemical\n.\tO\n\nEtiologic\tO\nfactors\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nliver\tB-Disease\ntumors\tI-Disease\nassociated\tO\nwith\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nWithin\tO\nthe\tO\nlast\tO\nseveral\tO\nyears\tO\n,\tO\npreviously\tO\nrare\tO\nliver\tB-Disease\ntumors\tI-Disease\nhave\tO\nbeen\tO\nseen\tO\nin\tO\nyoung\tO\nwomen\tO\nusing\tO\noral\tB-Chemical\ncontraceptive\tI-Chemical\nsteroids\tB-Chemical\n.\tO\n\nThe\tO\nRegistry\tO\nfor\tO\nLiver\tB-Disease\nTumors\tI-Disease\nAssociated\tO\nwith\tO\nOral\tB-Chemical\nContraceptives\tI-Chemical\nat\tO\nthe\tO\nUniversity\tO\nof\tO\nCalifornia\tO\n,\tO\nIrvine\tO\n,\tO\nhas\tO\nclearly\tO\nidentified\tO\n27\tO\ncases\tO\n.\tO\n\nThe\tO\nrecent\tO\nliterature\tO\ncontains\tO\n44\tO\ncase\tO\nreports\tO\n.\tO\n\nCommon\tO\nto\tO\nthese\tO\n71\tO\ncases\tO\nhas\tO\nbeen\tO\na\tO\nhistopathologic\tO\ndiagnosis\tO\nof\tO\nfocal\tB-Disease\nnodular\tI-Disease\nhyperplasia\tI-Disease\n,\tO\nadenoma\tB-Disease\n,\tO\nhamartoma\tB-Disease\n,\tO\nand\tO\nhepatoma\tB-Disease\n.\tO\n\nSignificant\tO\nstatistical\tO\netiologic\tO\nfactors\tO\ninclude\tO\nprolonged\tO\nuninterrupted\tO\nusage\tO\nof\tO\noral\tB-Chemical\ncontraceptive\tI-Chemical\nsteroids\tB-Chemical\n.\tO\n\nEight\tO\ndeaths\tO\nand\tO\nliver\tO\nrupture\tB-Disease\nin\tO\n18\tO\npatients\tO\nattest\tO\nto\tO\nthe\tO\nseriousness\tO\nof\tO\nthis\tO\nnew\tO\npotentially\tO\nlethal\tO\nadverse\tO\nphenomenon\tO\n.\tO\n\nIfosfamide\tB-Chemical\ncontinuous\tO\ninfusion\tO\nwithout\tO\nmesna\tB-Chemical\n.\tO\n\nA\tO\nphase\tO\nI\tO\ntrial\tO\nof\tO\na\tO\n14\tO\n-\tO\nday\tO\ncycle\tO\n.\tO\n\nTwenty\tO\npatients\tO\nreceived\tO\n27\tO\ncourses\tO\nof\tO\nifosfamide\tB-Chemical\nadministered\tO\nas\tO\na\tO\n24\tO\n-\tO\nhour\tO\ncontinuous\tO\ninfusion\tO\nfor\tO\n14\tO\ndays\tO\nwithout\tO\nMesna\tB-Chemical\n.\tO\n\nThe\tO\ngoal\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\ndeliver\tO\na\tO\ndose\tO\nrate\tO\nand\tO\ntotal\tO\ncumulative\tO\ndose\tO\nof\tO\nifosfamide\tB-Chemical\nthat\tO\nwould\tO\nbe\tO\ncomparable\tO\nto\tO\nstandard\tO\nbolus\tO\nor\tO\nshort\tO\n-\tO\nterm\tO\ninfusions\tO\nadministered\tO\nwith\tO\nMesna\tB-Chemical\n.\tO\n\nDose\tO\nescalations\tO\nproceeded\tO\nfrom\tO\n200\tO\nto\tO\n300\tO\n,\tO\n400\tO\n,\tO\n450\tO\n,\tO\n500\tO\n,\tO\nand\tO\n550\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nd\tO\n.\tO\n\nFour\tO\npatients\tO\ndeveloped\tO\ntransient\tO\nmicroscopic\tO\nhematuria\tB-Disease\nat\tO\n400\tO\n,\tO\n450\tO\n,\tO\nand\tO\n500\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nd\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\ninstances\tO\nof\tO\nmacroscopic\tO\nhematuria\tB-Disease\n.\tO\n\nAt\tO\n550\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nd\tO\n,\tO\nthree\tO\npatients\tO\nexperienced\tO\nnonurologic\tO\ntoxicity\tB-Disease\n;\tO\nconfusion\tB-Disease\n(\tO\n1\tO\n)\tO\n,\tO\nnausea\tB-Disease\n(\tO\n1\tO\n)\tO\n,\tO\nand\tO\nGrade\tO\n2\tO\nleukopenia\tB-Disease\n(\tO\n1\tO\n)\tO\n.\tO\n\nThe\tO\nrecommended\tO\ndose\tO\nof\tO\n500\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nd\tO\ndelivers\tO\na\tO\ntotal\tO\ndose\tO\nof\tO\n7\tO\ng\tO\n/\tO\nm2\tO\nper\tO\ncycle\tO\n,\tO\nwhich\tO\nis\tO\ncomparable\tO\nto\tO\nthat\tO\ndelivered\tO\nin\tO\nclinical\tO\npractice\tO\nfor\tO\nbolus\tO\nor\tO\nshort\tO\n-\tO\nterm\tO\ninfusion\tO\n.\tO\n\nBecause\tO\nfew\tO\npatients\tO\nreceived\tO\nmultiple\tO\ncourses\tO\nover\tO\ntime\tO\n,\tO\nthe\tO\ncumulative\tO\neffects\tO\nare\tO\nindeterminate\tO\nin\tO\nthe\tO\npresent\tO\ntrial\tO\n.\tO\n\nThe\tO\nfrequency\tO\nand\tO\npredictability\tO\nof\tO\nhematuria\tB-Disease\nare\tO\nnot\tO\nprecise\tO\n,\tO\nand\tO\nat\tO\nleast\tO\ndaily\tO\nmonitoring\tO\nby\tO\nurine\tO\nHematest\tO\nis\tO\nessential\tO\n,\tO\nadding\tO\nMesna\tB-Chemical\nto\tO\nthe\tO\ninfusate\tO\nin\tO\npatients\tO\nwith\tO\npersistent\tO\nhematuria\tB-Disease\n.\tO\n\nThe\tO\nprotracted\tO\ninfusion\tO\nschedule\tO\nfor\tO\nifosfamide\tB-Chemical\npermits\tO\nconvenient\tO\noutpatient\tO\nadministration\tO\nwithout\tO\nMesna\tB-Chemical\nand\tO\nreduces\tO\nthe\tO\ndrug\tO\ncost\tO\nof\tO\nclinical\tO\nusage\tO\nof\tO\nthis\tO\nagent\tO\nby\tO\nup\tO\nto\tO\n890\tO\nper\tO\ncycle\tO\n.\tO\n\nClinical\tO\nactivity\tO\nwas\tO\ndemonstrated\tO\nin\tO\na\tO\nsingle\tO\npatient\tO\n,\tO\nbut\tO\na\tO\ncomparative\tO\ntrial\tO\nof\tO\nstandard\tO\nbolus\tO\nschedules\tO\nwith\tO\nthe\tO\nprotracted\tO\ninfusion\tO\nschedule\tO\nwill\tO\nbe\tO\nnecessary\tO\nto\tO\ndetermine\tO\nif\tO\nthe\tO\nclinical\tO\neffectiveness\tO\nof\tO\nthe\tO\ndrug\tO\nis\tO\nmaintained\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nrelated\tO\nto\tO\ncaffeine\tB-Chemical\npretreatment\tO\n.\tO\n\nSuboptimal\tO\nseizure\tB-Disease\nduration\tO\nis\tO\ncommonly\tO\nencountered\tO\nin\tO\nelectroconvulsive\tO\ntherapy\tO\npractice\tO\n,\tO\nespecially\tO\nin\tO\nolder\tO\npatients\tO\nwith\tO\nhigher\tO\nseizure\tB-Disease\nthresholds\tO\n.\tO\n\nIntravenous\tO\ncaffeine\tB-Chemical\nis\tO\ncommonly\tO\nused\tO\nto\tO\nimprove\tO\nseizure\tB-Disease\nduration\tO\nand\tO\nquality\tO\nin\tO\nsuch\tO\npatients\tO\nand\tO\nis\tO\ngenerally\tO\nwell\tO\ntolerated\tO\naside\tO\nfrom\tO\noccasional\tO\nreports\tO\nof\tO\nrelatively\tO\nbenign\tO\nventricular\tB-Disease\nectopy\tI-Disease\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\npatient\tO\nwith\tO\nno\tO\nprevious\tO\nhistory\tO\nof\tO\ncardiac\tB-Disease\ndisease\tI-Disease\nor\tO\narrhythmia\tB-Disease\nwho\tO\ndeveloped\tO\nsustained\tO\nbigeminy\tO\nand\tO\n2\tO\nbrief\tO\nruns\tO\nof\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nafter\tO\ncaffeine\tB-Chemical\nadministration\tO\n.\tO\n\nAlthough\tO\nintravenous\tO\ncaffeine\tB-Chemical\nis\tO\ngenerally\tO\nwell\tO\ntolerated\tO\n,\tO\nthe\tO\nclinician\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthe\tO\npotential\tO\nfor\tO\nunpredictable\tO\nand\tO\nserious\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\n.\tO\n\nFatal\tO\nhaemopericardium\tB-Disease\nand\tO\ngastrointestinal\tB-Disease\nhaemorrhage\tI-Disease\ndue\tO\nto\tO\npossible\tO\ninteraction\tO\nof\tO\ncranberry\tO\njuice\tO\nwith\tO\nwarfarin\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nfatal\tO\ninternal\tO\nhaemorrhage\tB-Disease\nin\tO\nan\tO\nelderly\tO\nman\tO\nwho\tO\nconsumed\tO\nonly\tO\ncranberry\tO\njuice\tO\nfor\tO\ntwo\tO\nweeks\tO\nwhile\tO\nmaintaining\tO\nhis\tO\nusual\tO\ndosage\tO\nof\tO\nwarfarin\tB-Chemical\n.\tO\n\nWe\tO\npropose\tO\nthat\tO\nnaturally\tO\noccurring\tO\ncompounds\tO\nsuch\tO\nas\tO\nflavonoids\tB-Chemical\n,\tO\nwhich\tO\nare\tO\npresent\tO\nin\tO\nfruit\tO\njuices\tO\n,\tO\nmay\tO\nincrease\tO\nthe\tO\npotency\tO\nof\tO\nwarfarin\tB-Chemical\nby\tO\ncompeting\tO\nfor\tO\nthe\tO\nenzymes\tO\nthat\tO\nnormally\tO\ninactivate\tO\nwarfarin\tB-Chemical\n.\tO\n\nWhile\tO\ntraditionally\tO\nregarded\tO\nas\tO\nfoodstuffs\tO\n,\tO\nconsumption\tO\nof\tO\nfruit\tO\njuices\tO\nshould\tO\nbe\tO\nconsidered\tO\nwhen\tO\npatients\tO\ndevelop\tO\nadverse\tO\ndrug\tO\nreactions\tO\n.\tO\n\nEffect\tO\nof\tO\nincreasing\tO\nintraperitoneal\tO\ninfusion\tO\nrates\tO\non\tO\nbupropion\tB-Chemical\nhydrochloride\tI-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIt\tO\nis\tO\nnot\tO\nknown\tO\nif\tO\nthere\tO\nis\tO\na\tO\nrelationship\tO\nbetween\tO\ninput\tO\nrate\tO\nand\tO\nincidence\tO\nof\tO\nbupropion\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nThis\tO\nis\tO\nimportant\tO\n,\tO\nsince\tO\ndifferent\tO\ncontrolled\tO\nrelease\tO\nformulations\tO\nof\tO\nbupropion\tB-Chemical\nrelease\tO\nthe\tO\nactive\tO\ndrug\tO\nat\tO\ndifferent\tO\nrates\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\ninvestigated\tO\nthe\tO\neffect\tO\nof\tO\nvarying\tO\nthe\tO\nintraperitoneal\tO\ninfusion\tO\nrates\tO\nof\tO\nbupropion\tB-Chemical\nHCl\tI-Chemical\n120\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\na\tO\nknown\tO\nconvulsive\tB-Disease\ndose\tO\n50\tO\n(\tO\nCD50\tO\n)\tO\n,\tO\non\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nbupropion\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nin\tO\nthe\tO\nSwiss\tO\nalbino\tO\nmice\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n69\tO\nmice\tO\n,\tO\napproximately\tO\n7\tO\nweeks\tO\nof\tO\nage\tO\n,\tO\nand\tO\nweighing\tO\n21\tO\n.\tO\n0\tO\nto\tO\n29\tO\n.\tO\n1\tO\ng\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nbupropion\tB-Chemical\nHCl\tI-Chemical\n120\tO\nmg\tO\n/\tO\nkg\tO\ntreatment\tO\nby\tO\nintraperitoneal\tO\n(\tO\nIP\tO\n)\tO\nadministration\tO\nin\tO\n7\tO\ngroups\tO\n(\tO\n9\tO\nto\tO\n10\tO\nanimals\tO\nper\tO\ngroup\tO\n)\tO\n.\tO\n\nBupropion\tB-Chemical\nHCl\tI-Chemical\nwas\tO\ninfused\tO\nthrough\tO\na\tO\nsurgically\tO\nimplanted\tO\nIP\tO\ndosing\tO\ncatheter\tO\nwith\tO\ninfusions\tO\nin\tO\neach\tO\ngroup\tO\nof\tO\n0\tO\nmin\tO\n,\tO\n15\tO\nmin\tO\n,\tO\n30\tO\nmin\tO\n,\tO\n60\tO\nmin\tO\n,\tO\n90\tO\nmin\tO\n,\tO\n120\tO\nmin\tO\n,\tO\nand\tO\n240\tO\nmin\tO\n.\tO\n\nThe\tO\nnumber\tO\n,\tO\ntime\tO\nof\tO\nonset\tO\n,\tO\nduration\tO\nand\tO\nthe\tO\nintensity\tO\nof\tO\nthe\tO\nconvulsions\tB-Disease\nor\tO\nabsence\tO\nof\tO\nconvulsions\tB-Disease\nwere\tO\nrecorded\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nresults\tO\nshowed\tO\nthat\tO\nIP\tO\nadministration\tO\nof\tO\nbupropion\tB-Chemical\nHCl\tI-Chemical\n120\tO\nmg\tO\n/\tO\nkg\tO\nby\tO\nbolus\tO\ninjection\tO\ninduced\tO\nconvulsions\tB-Disease\nin\tO\n6\tO\nout\tO\nof\tO\n10\tO\nmice\tO\n(\tO\n60\tO\n%\tO\nof\tO\nconvulsing\tO\nmice\tO\n)\tO\nin\tO\ngroup\tO\n1\tO\n.\tO\n\nLogistic\tO\nregression\tO\nanalysis\tO\nrevealed\tO\nthat\tO\ninfusion\tO\ntime\tO\nwas\tO\nsignificant\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n0004\tO\n;\tO\nodds\tO\nratio\tO\n=\tO\n0\tO\n.\tO\n974\tO\n)\tO\nand\tO\nincreasing\tO\nthe\tO\nIP\tO\ninfusion\tO\ntime\tO\nof\tO\nbupropion\tB-Chemical\nHCl\tI-Chemical\n120\tO\nmg\tO\n/\tO\nkg\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\n91\tO\n%\tO\nreduced\tO\nodds\tO\nof\tO\nconvulsions\tB-Disease\nat\tO\ninfusion\tO\ntimes\tO\nof\tO\n15\tO\nto\tO\n90\tO\nmin\tO\ncompared\tO\nto\tO\nbolus\tO\ninjection\tO\n.\tO\n\nFurther\tO\nincrease\tO\nin\tO\ninfusion\tO\ntime\tO\nresulted\tO\nin\tO\nfurther\tO\nreduction\tO\nin\tO\nthe\tO\nodds\tO\nof\tO\nconvulsions\tB-Disease\nto\tO\n99\tO\n.\tO\n8\tO\n%\tO\nreduction\tO\nat\tO\n240\tO\nmin\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\ndemonstration\tO\nof\tO\nan\tO\ninverse\tO\nrelationship\tO\nbetween\tO\ninfusion\tO\ntime\tO\nof\tO\na\tO\nfixed\tO\nand\tO\nconvulsive\tB-Disease\ndose\tO\nof\tO\nbupropion\tB-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nconvulsions\tB-Disease\nin\tO\na\tO\nprospective\tO\nstudy\tO\nis\tO\nnovel\tO\n.\tO\n\nGraft\tB-Disease\n-\tI-Disease\nversus\tI-Disease\n-\tI-Disease\nhost\tI-Disease\ndisease\tI-Disease\nprophylaxis\tO\nwith\tO\neverolimus\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\nis\tO\nassociated\tO\nwith\tO\na\tO\nhigh\tO\nincidence\tO\nof\tO\nsinusoidal\tB-Disease\nobstruction\tI-Disease\nsyndrome\tI-Disease\nand\tO\nmicroangiopathy\tB-Disease\n:\tO\nresults\tO\nof\tO\nthe\tO\nEVTAC\tO\ntrial\tO\n.\tO\n\nA\tO\ncalcineurin\tO\ninhibitor\tO\ncombined\tO\nwith\tO\nmethotrexate\tB-Chemical\nis\tO\nthe\tO\nstandard\tO\nprophylaxis\tO\nfor\tO\ngraft\tB-Disease\n-\tI-Disease\nversus\tI-Disease\n-\tI-Disease\nhost\tI-Disease\ndisease\tI-Disease\n(\tO\nGVHD\tB-Disease\n)\tO\nafter\tO\nallogeneic\tO\nhematopoietic\tO\nstem\tO\ncell\tO\ntransplantation\tO\n(\tO\nHSCT\tO\n)\tO\n.\tO\n\nEverolimus\tB-Chemical\n,\tO\na\tO\nderivative\tO\nof\tO\nsirolimus\tB-Chemical\n,\tO\nseems\tO\nto\tO\nmediate\tO\nantileukemia\tO\neffects\tO\n.\tO\n\nWe\tO\nreport\tO\non\tO\na\tO\ncombination\tO\nof\tO\neverolimus\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\nin\tO\n24\tO\npatients\tO\n(\tO\nmedian\tO\nage\tO\n,\tO\n62\tO\nyears\tO\n)\tO\nwith\tO\neither\tO\nmyelodysplastic\tB-Disease\nsyndrome\tI-Disease\n(\tO\nMDS\tB-Disease\n;\tO\nn\tO\n=\tO\n17\tO\n)\tO\nor\tO\nacute\tB-Disease\nmyeloid\tI-Disease\nleukemia\tI-Disease\n(\tO\nAML\tB-Disease\n;\tO\nn\tO\n=\tO\n7\tO\n)\tO\nundergoing\tO\nintensive\tO\nconditioning\tO\nfollowed\tO\nby\tO\nHSCT\tO\nfrom\tO\nrelated\tO\n(\tO\nn\tO\n=\tO\n4\tO\n)\tO\nor\tO\nunrelated\tO\n(\tO\nn\tO\n=\tO\n20\tO\n)\tO\ndonors\tO\n.\tO\n\nAll\tO\npatients\tO\nengrafted\tO\n,\tO\nand\tO\nonly\tO\n1\tO\npatient\tO\nexperienced\tO\ngrade\tO\nIV\tO\nmucositis\tB-Disease\n.\tO\n\nNine\tO\npatients\tO\n(\tO\n37\tO\n%\tO\n)\tO\ndeveloped\tO\nacute\tO\ngrade\tO\nII\tO\n-\tO\nIV\tO\nGVHD\tB-Disease\n,\tO\nand\tO\n11\tO\nof\tO\n17\tO\nevaluable\tO\npatients\tO\n(\tO\n64\tO\n%\tO\n)\tO\ndeveloped\tO\nchronic\tO\nextensive\tO\nGVHD\tB-Disease\n.\tO\n\nTransplantation\tB-Disease\n-\tI-Disease\nassociated\tI-Disease\nmicroangiopathy\tI-Disease\n(\tO\nTMA\tB-Disease\n)\tO\noccurred\tO\nin\tO\n7\tO\npatients\tO\n(\tO\n29\tO\n%\tO\n)\tO\n,\tO\nwith\tO\n2\tO\ncases\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nThe\tO\nstudy\tO\nwas\tO\nterminated\tO\nprematurely\tO\nbecause\tO\nan\tO\nadditional\tO\n6\tO\npatients\tO\n(\tO\n25\tO\n%\tO\n)\tO\ndeveloped\tO\nsinusoidal\tB-Disease\nobstruction\tI-Disease\nsyndrome\tI-Disease\n(\tO\nSOS\tB-Disease\n)\tO\n,\tO\nwhich\tO\nwas\tO\nfatal\tO\nin\tO\n2\tO\ncases\tO\n.\tO\n\nWith\tO\na\tO\nmedian\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n26\tO\nmonths\tO\n,\tO\nthe\tO\n2\tO\n-\tO\nyear\tO\noverall\tO\nsurvival\tO\nrate\tO\nwas\tO\n47\tO\n%\tO\n.\tO\n\nAlthough\tO\nthis\tO\nnew\tO\ncombination\tO\nappears\tO\nto\tO\nbe\tO\neffective\tO\nas\tO\na\tO\nprophylactic\tO\nregimen\tO\nfor\tO\nacute\tO\nGVHD\tB-Disease\n,\tO\nthe\tO\nincidence\tO\nof\tO\nTMA\tB-Disease\nand\tO\nSOS\tB-Disease\nis\tO\nconsiderably\tO\nhigher\tO\nthan\tO\nseen\tO\nwith\tO\nother\tO\nregimens\tO\n.\tO\n\nLongitudinal\tO\nassessment\tO\nof\tO\nair\tO\nconduction\tO\naudiograms\tO\nin\tO\na\tO\nphase\tO\nIII\tO\nclinical\tO\ntrial\tO\nof\tO\ndifluoromethylornithine\tB-Chemical\nand\tO\nsulindac\tB-Chemical\nfor\tO\nprevention\tO\nof\tO\nsporadic\tO\ncolorectal\tB-Disease\nadenomas\tI-Disease\n.\tO\n\nA\tO\nphase\tO\nIII\tO\nclinical\tO\ntrial\tO\nassessed\tO\nthe\tO\nrecurrence\tO\nof\tO\nadenomatous\tB-Disease\npolyps\tI-Disease\nafter\tO\ntreatment\tO\nfor\tO\n36\tO\nmonths\tO\nwith\tO\ndifluoromethylornithine\tB-Chemical\n(\tO\nDFMO\tB-Chemical\n)\tO\nplus\tO\nsulindac\tB-Chemical\nor\tO\nmatched\tO\nplacebos\tO\n.\tO\n\nTemporary\tO\nhearing\tB-Disease\nloss\tI-Disease\nis\tO\na\tO\nknown\tO\ntoxicity\tB-Disease\nof\tO\ntreatment\tO\nwith\tO\nDFMO\tB-Chemical\n,\tO\nthus\tO\na\tO\ncomprehensive\tO\napproach\tO\nwas\tO\ndeveloped\tO\nto\tO\nanalyze\tO\nserial\tO\nair\tO\nconduction\tO\naudiograms\tO\n.\tO\n\nThe\tO\ngeneralized\tO\nestimating\tO\nequation\tO\nmethod\tO\nestimated\tO\nthe\tO\nmean\tO\ndifference\tO\nbetween\tO\ntreatment\tO\narms\tO\nwith\tO\nregard\tO\nto\tO\nchange\tO\nin\tO\nair\tO\nconduction\tO\npure\tO\ntone\tO\nthresholds\tO\nwhile\tO\naccounting\tO\nfor\tO\nwithin\tO\n-\tO\nsubject\tO\ncorrelation\tO\ndue\tO\nto\tO\nrepeated\tO\nmeasurements\tO\nat\tO\nfrequencies\tO\n.\tO\n\nBased\tO\non\tO\n290\tO\nsubjects\tO\n,\tO\nthere\tO\nwas\tO\nan\tO\naverage\tO\ndifference\tO\nof\tO\n0\tO\n.\tO\n50\tO\ndB\tO\nbetween\tO\nsubjects\tO\ntreated\tO\nwith\tO\nDFMO\tB-Chemical\nplus\tO\nsulindac\tB-Chemical\ncompared\tO\nwith\tO\nthose\tO\ntreated\tO\nwith\tO\nplacebo\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n-\tO\n0\tO\n.\tO\n64\tO\nto\tO\n1\tO\n.\tO\n63\tO\ndB\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n39\tO\n)\tO\n,\tO\nadjusted\tO\nfor\tO\nbaseline\tO\nvalues\tO\n,\tO\nage\tO\n,\tO\nand\tO\nfrequencies\tO\n.\tO\n\nIn\tO\nthe\tO\nnormal\tO\nspeech\tO\nrange\tO\nof\tO\n500\tO\nto\tO\n3\tO\n,\tO\n000\tO\nHz\tO\n,\tO\nan\tO\nestimated\tO\ndifference\tO\nof\tO\n0\tO\n.\tO\n99\tO\ndB\tO\n(\tO\n-\tO\n0\tO\n.\tO\n17\tO\nto\tO\n2\tO\n.\tO\n14\tO\ndB\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n09\tO\n)\tO\nwas\tO\ndetected\tO\n.\tO\n\nDose\tO\nintensity\tO\ndid\tO\nnot\tO\nadd\tO\ninformation\tO\nto\tO\nmodels\tO\n.\tO\n\nThere\tO\nwere\tO\n14\tO\nof\tO\n151\tO\n(\tO\n9\tO\n.\tO\n3\tO\n%\tO\n)\tO\nin\tO\nthe\tO\nDFMO\tB-Chemical\nplus\tO\nsulindac\tB-Chemical\ngroup\tO\nand\tO\n4\tO\nof\tO\n139\tO\n(\tO\n2\tO\n.\tO\n9\tO\n%\tO\n)\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\nwho\tO\nexperienced\tO\nat\tO\nleast\tO\n15\tO\ndB\tO\nhearing\tO\nreduction\tO\nfrom\tO\nbaseline\tO\nin\tO\n2\tO\nor\tO\nmore\tO\nconsecutive\tO\nfrequencies\tO\nacross\tO\nthe\tO\nentire\tO\nrange\tO\ntested\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nFollow\tO\n-\tO\nup\tO\nair\tO\nconduction\tO\ndone\tO\nat\tO\nleast\tO\n6\tO\nmonths\tO\nafter\tO\nend\tO\nof\tO\ntreatment\tO\nshowed\tO\nan\tO\nadjusted\tO\nmean\tO\ndifference\tO\nin\tO\nhearing\tO\nthresholds\tO\nof\tO\n1\tO\n.\tO\n08\tO\ndB\tO\n(\tO\n-\tO\n0\tO\n.\tO\n81\tO\nto\tO\n2\tO\n.\tO\n96\tO\ndB\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n26\tO\n)\tO\nbetween\tO\ntreatment\tO\narms\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nsignificant\tO\ndifference\tO\nin\tO\nthe\tO\nproportion\tO\nof\tO\nsubjects\tO\nin\tO\nthe\tO\nDFMO\tB-Chemical\nplus\tO\nsulindac\tB-Chemical\ngroup\tO\nwho\tO\nexperienced\tO\nclinically\tO\nsignificant\tO\nhearing\tB-Disease\nloss\tI-Disease\ncompared\tO\nwith\tO\nthe\tO\nplacebo\tO\ngroup\tO\n.\tO\n\nThe\tO\nestimated\tO\nattributable\tO\nrisk\tO\nof\tO\nototoxicity\tB-Disease\nfrom\tO\nexposure\tO\nto\tO\nthe\tO\ndrug\tO\nis\tO\n8\tO\n.\tO\n4\tO\n%\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n-\tO\n2\tO\n.\tO\n0\tO\n%\tO\nto\tO\n18\tO\n.\tO\n8\tO\n%\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n12\tO\n)\tO\n.\tO\n\nThere\tO\nis\tO\na\tO\n<\tO\n2\tO\ndB\tO\ndifference\tO\nin\tO\nmean\tO\nthreshold\tO\nfor\tO\npatients\tO\ntreated\tO\nwith\tO\nDFMO\tB-Chemical\nplus\tO\nsulindac\tB-Chemical\ncompared\tO\nwith\tO\nthose\tO\ntreated\tO\nwith\tO\nplacebo\tO\n.\tO\n\nProteinase\tO\n3\tO\n-\tO\nantineutrophil\tO\ncytoplasmic\tO\nantibody\tO\n-\tO\n(\tO\nPR3\tO\n-\tO\nANCA\tO\n)\tO\npositive\tO\nnecrotizing\tO\nglomerulonephritis\tB-Disease\nafter\tO\nrestarting\tO\nsulphasalazine\tB-Chemical\ntreatment\tO\n.\tO\n\nA\tO\n59\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nulcerative\tB-Disease\ncolitis\tI-Disease\ndeveloped\tO\nred\tB-Disease\neyes\tI-Disease\n,\tO\npleural\tB-Disease\neffusion\tI-Disease\n,\tO\neosinophilia\tB-Disease\nand\tO\nurinary\tB-Disease\nabnormalities\tI-Disease\nafter\tO\nrestarting\tO\nof\tO\nsulphasalazine\tB-Chemical\ntreatment\tO\n.\tO\n\nLight\tO\nmicroscopy\tO\nof\tO\na\tO\nkidney\tO\nbiopsy\tO\nrevealed\tO\nsegmental\tB-Disease\nnecrotizing\tI-Disease\nglomerulonephritis\tI-Disease\nwithout\tO\ndeposition\tO\nof\tO\nimmunoglobulin\tO\nor\tO\ncomplement\tO\n.\tO\n\nProteinase\tO\n3\tO\n-\tO\nantineutrophil\tO\ncytoplasmic\tO\nantibody\tO\n(\tO\nPR3\tO\n-\tO\nANCA\tO\n)\tO\ntiter\tO\nwas\tO\nelevated\tO\nat\tO\n183\tO\nELISA\tO\nunits\tO\n(\tO\nEU\tO\n)\tO\nin\tO\nsera\tO\n(\tO\nnormal\tO\nrange\tO\nless\tO\nthan\tO\n10\tO\nEU\tO\n)\tO\n,\tO\nmyeloperoxidase\tO\n-\tO\nANCA\tO\nwas\tO\nnegative\tO\n.\tO\n\nPR3\tO\n-\tO\nANCA\tO\ntiter\tO\nwas\tO\n250\tO\nand\tO\n1\tO\n,\tO\n070\tO\nEU\tO\nin\tO\npleural\tB-Disease\neffusions\tI-Disease\non\tO\nright\tO\nand\tO\nleft\tO\nside\tO\n,\tO\nrespectively\tO\n.\tO\n\nAlthough\tO\ncessation\tO\nof\tO\nsulphasalazine\tB-Chemical\ntreatment\tO\nresulted\tO\nin\tO\nimprovements\tO\nin\tO\nfever\tB-Disease\n,\tO\nred\tB-Disease\neyes\tI-Disease\n,\tO\nchest\tB-Disease\npain\tI-Disease\n,\tO\ntiter\tO\nof\tO\nC\tO\n-\tO\nreactive\tO\nprotein\tO\nand\tO\nvolume\tO\nof\tO\nthe\tO\npleural\tB-Disease\neffusions\tI-Disease\n,\tO\nwe\tO\ninitiated\tO\nsteroid\tB-Chemical\ntherapy\tO\n,\tO\nbecause\tO\nPR3\tO\n-\tO\nANCA\tO\ntiter\tO\nrose\tO\nto\tO\n320\tO\nEU\tO\n,\tO\neosinophil\tO\ncount\tO\nincreased\tO\nto\tO\n1\tO\n,\tO\n100\tO\ncells\tO\n/\tO\nmicrol\tO\n,\tO\nand\tO\nthe\tO\npleural\tB-Disease\neffusion\tI-Disease\nremained\tO\n.\tO\n\nOne\tO\nmonth\tO\nafter\tO\nsteroid\tB-Chemical\ntherapy\tO\n,\tO\nthe\tO\npleural\tB-Disease\neffusion\tI-Disease\ndisappeared\tO\n,\tO\nand\tO\nPR3\tO\n-\tO\nANCA\tO\ntiter\tO\nnormalized\tO\n3\tO\nmonths\tO\nlater\tO\n.\tO\n\nThis\tO\ncase\tO\nsuggests\tO\nthat\tO\nsulphasalazine\tB-Chemical\ncan\tO\ninduce\tO\nPR3\tO\n-\tO\nANCA\tO\n-\tO\npositive\tO\nnecrotizing\tO\nglomerulonephritis\tB-Disease\n.\tO\n\nComparison\tO\nof\tO\nunilateral\tO\npallidotomy\tO\nand\tO\nsubthalamotomy\tO\nfindings\tO\nin\tO\nadvanced\tO\nidiopathic\tB-Disease\nParkinson\tI-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nA\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\npilot\tO\nstudy\tO\nto\tO\ncompare\tO\nthe\tO\nresults\tO\nof\tO\nstereotactic\tO\nunilateral\tO\npallidotomy\tO\nand\tO\nsubthalamotomy\tO\nin\tO\nadvanced\tO\nidiopathic\tB-Disease\nParkinson\tI-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\nrefractory\tO\nto\tO\nmedical\tO\ntreatment\tO\nwas\tO\ndesigned\tO\n.\tO\n\nTen\tO\nconsecutive\tO\npatients\tO\n(\tO\nmean\tO\nage\tO\n,\tO\n58\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n8\tO\nyears\tO\n;\tO\n7\tO\nmen\tO\n,\tO\n3\tO\nwomen\tO\n)\tO\nwith\tO\nsimilar\tO\ncharacteristics\tO\nat\tO\nthe\tO\nduration\tO\nof\tO\ndisease\tO\n(\tO\nmean\tO\ndisease\tO\ntime\tO\n,\tO\n8\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n5\tO\nyears\tO\n)\tO\n,\tO\ndisabling\tO\nmotor\tO\nfluctuations\tO\n(\tO\nHoehn\tO\n_\tO\nYahr\tO\nstage\tO\n3\tO\n-\tO\n5\tO\nin\tO\noff\tO\n-\tO\ndrug\tO\nphases\tO\n)\tO\nand\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nwere\tO\nselected\tO\n.\tO\n\nAll\tO\npatients\tO\nhad\tO\nbilateral\tO\nsymptoms\tO\nand\tO\ntheir\tO\nlevodopa\tB-Chemical\nequivalent\tO\ndosing\tO\nwere\tO\nanalysed\tO\n.\tO\n\nSix\tO\npatients\tO\nwere\tO\noperated\tO\non\tO\nin\tO\nthe\tO\nglobus\tO\npallidus\tO\ninterna\tO\n(\tO\nGPi\tO\n)\tO\nand\tO\nfour\tO\nin\tO\nthe\tO\nsubthalamic\tO\nnucleus\tO\n(\tO\nSTN\tO\n)\tO\n.\tO\n\nClinical\tO\nevaluation\tO\nincluded\tO\nthe\tO\nuse\tO\nof\tO\nthe\tO\nUnified\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nRating\tO\nScale\tO\n(\tO\nUPDRS\tO\n)\tO\n,\tO\nHoehn\tO\n_\tO\nYahr\tO\nscore\tO\nand\tO\nSchwab\tO\nEngland\tO\nactivities\tO\nof\tO\ndaily\tO\nliving\tO\n(\tO\nADL\tO\n)\tO\nscore\tO\nin\tO\n'\tO\non\tO\n'\tO\n-\tO\nand\tO\n'\tO\noff\tO\n'\tO\n-\tO\ndrug\tO\nconditions\tO\nbefore\tO\nsurgery\tO\nand\tO\n6\tO\nmonths\tO\nafter\tO\nsurgery\tO\n.\tO\n\nThere\tO\nwas\tO\nstatistically\tO\nsignificant\tO\nimprovement\tO\nin\tO\nall\tO\ncontralateral\tO\nmajor\tO\nparkinsonian\tB-Disease\nmotor\tO\nsigns\tO\nin\tO\nall\tO\npatients\tO\nfollowed\tO\nfor\tO\n6\tO\nmonths\tO\n.\tO\n\nLevodopa\tB-Chemical\nequivalent\tO\ndaily\tO\nintake\tO\nwas\tO\nsignificantly\tO\nreduced\tO\nin\tO\nthe\tO\nSTN\tO\ngroup\tO\n.\tO\n\nChanges\tO\nin\tO\nUPDRS\tO\n,\tO\nHoehn\tO\n_\tO\nYahr\tO\nand\tO\nSchwab\tO\nEngland\tO\nADL\tO\nscores\tO\nwere\tO\nsimilar\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nCognitive\tO\nfunctions\tO\nwere\tO\nunchanged\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nComplications\tO\nwere\tO\nobserved\tO\nin\tO\ntwo\tO\npatients\tO\n:\tO\none\tO\nhad\tO\na\tO\nleft\tO\nhomonymous\tB-Disease\nhemianopsia\tI-Disease\nafter\tO\npallidotomy\tO\nand\tO\nanother\tO\none\tO\ndeveloped\tO\nleft\tO\nhemiballistic\tO\nmovements\tO\n3\tO\ndays\tO\nafter\tO\nsubthalamotomy\tO\nwhich\tO\npartly\tO\nimproved\tO\nwithin\tO\n1\tO\nmonth\tO\nwith\tO\nValproate\tB-Chemical\n1000\tO\nmg\tO\n/\tO\nday\tO\n.\tO\n\nThe\tO\nfindings\tO\nof\tO\nthis\tO\nstudy\tO\nsuggest\tO\nthat\tO\nlesions\tO\nof\tO\nthe\tO\nunilateral\tO\nSTN\tO\nand\tO\nGPi\tO\nare\tO\nequally\tO\neffective\tO\ntreatment\tO\nfor\tO\npatients\tO\nwith\tO\nadvanced\tO\nPD\tB-Disease\nrefractory\tO\nto\tO\nmedical\tO\ntreatment\tO\n.\tO\n\nDSMM\tO\nXI\tO\nstudy\tO\n:\tO\ndose\tO\ndefinition\tO\nfor\tO\nintravenous\tO\ncyclophosphamide\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nbortezomib\tB-Chemical\n/\tO\ndexamethasone\tB-Chemical\nfor\tO\nremission\tO\ninduction\tO\nin\tO\npatients\tO\nwith\tO\nnewly\tO\ndiagnosed\tO\nmyeloma\tB-Disease\n.\tO\n\nA\tO\nclinical\tO\ntrial\tO\nwas\tO\ninitiated\tO\nto\tO\nevaluate\tO\nthe\tO\nrecommended\tO\ndose\tO\nof\tO\ncyclophosphamide\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nbortezomib\tB-Chemical\nand\tO\ndexamethasone\tB-Chemical\nas\tO\ninduction\tO\ntreatment\tO\nbefore\tO\nstem\tO\ncell\tO\ntransplantation\tO\nfor\tO\nyounger\tO\npatients\tO\nwith\tO\nnewly\tO\ndiagnosed\tO\nmultiple\tB-Disease\nmyeloma\tI-Disease\n(\tO\nMM\tB-Disease\n)\tO\n.\tO\n\nThirty\tO\npatients\tO\nwere\tO\ntreated\tO\nwith\tO\nthree\tO\n21\tO\n-\tO\nday\tO\ncycles\tO\nof\tO\nbortezomib\tB-Chemical\n1\tO\n.\tO\n3\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\non\tO\ndays\tO\n1\tO\n,\tO\n4\tO\n,\tO\n8\tO\n,\tO\nand\tO\n11\tO\nplus\tO\ndexamethasone\tB-Chemical\n40\tO\nmg\tO\non\tO\nthe\tO\nday\tO\nof\tO\nbortezomib\tB-Chemical\ninjection\tO\nand\tO\nthe\tO\nday\tO\nafter\tO\nplus\tO\ncyclophosphamide\tB-Chemical\nat\tO\n900\tO\n,\tO\n1\tO\n,\tO\n200\tO\n,\tO\nor\tO\n1\tO\n,\tO\n500\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\non\tO\nday\tO\n1\tO\n.\tO\n\nThe\tO\nmaximum\tO\ntolerated\tO\ndose\tO\nof\tO\ncyclophosphamide\tB-Chemical\nwas\tO\ndefined\tO\nas\tO\n900\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n.\tO\n\nAt\tO\nthis\tO\ndose\tO\nlevel\tO\n,\tO\n92\tO\n%\tO\nof\tO\npatients\tO\nachieved\tO\nat\tO\nleast\tO\na\tO\npartial\tO\nresponse\tO\n.\tO\n\nThe\tO\noverall\tO\nresponse\tO\nrate\tO\n[\tO\ncomplete\tO\nresponse\tO\n(\tO\nCR\tO\n)\tO\nplus\tO\npartial\tO\nresponse\tO\n(\tO\nPR\tO\n)\tO\n]\tO\nacross\tO\nall\tO\ndose\tO\nlevels\tO\nwas\tO\n77\tO\n%\tO\n,\tO\nwith\tO\na\tO\n10\tO\n%\tO\nCR\tO\nrate\tO\n.\tO\n\nNo\tO\npatient\tO\nexperienced\tO\nprogressive\tO\ndisease\tO\n.\tO\n\nThe\tO\nmost\tO\nfrequent\tO\nadverse\tO\nevents\tO\nwere\tO\nhematological\tB-Disease\nand\tI-Disease\ngastrointestinal\tI-Disease\ntoxicities\tI-Disease\nas\tO\nwell\tO\nas\tO\nneuropathy\tB-Disease\n.\tO\n\nThe\tO\nresults\tO\nsuggest\tO\nthat\tO\nbortezomib\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\ncyclophosphamide\tB-Chemical\nat\tO\n900\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nand\tO\ndexamethasone\tB-Chemical\nis\tO\nan\tO\neffective\tO\ninduction\tO\ntreatment\tO\nfor\tO\npatients\tO\nwith\tO\nnewly\tO\ndiagnosed\tO\nMM\tB-Disease\nthat\tO\nwarrants\tO\nfurther\tO\ninvestigation\tO\n.\tO\n\nNaloxone\tB-Chemical\nreversal\tO\nof\tO\nhypotension\tB-Disease\ndue\tO\nto\tO\ncaptopril\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nThe\tO\nhemodynamic\tO\neffects\tO\nof\tO\ncaptopril\tB-Chemical\nand\tO\nother\tO\nangiotensin\tB-Chemical\n-\tI-Chemical\nconverting\tI-Chemical\nenzyme\tI-Chemical\ninhibitors\tI-Chemical\nmay\tO\nbe\tO\nmediated\tO\nby\tO\nthe\tO\nendogenous\tO\nopioid\tO\nsystem\tO\n.\tO\n\nThe\tO\nopioid\tO\nantagonist\tO\nnaloxone\tB-Chemical\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nblock\tO\nor\tO\nreverse\tO\nthe\tO\nhypotensive\tB-Disease\nactions\tO\nof\tO\ncaptopril\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nan\tO\nintentional\tO\ncaptopril\tB-Chemical\noverdose\tB-Disease\n,\tO\nmanifested\tO\nby\tO\nmarked\tO\nhypotension\tB-Disease\n,\tO\nthat\tO\nresolved\tO\npromptly\tO\nwith\tO\nthe\tO\nadministration\tO\nof\tO\nnaloxone\tB-Chemical\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\nreported\tO\ncase\tO\nof\tO\ncaptopril\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\ntreated\tO\nwith\tO\nnaloxone\tB-Chemical\n.\tO\n\nOur\tO\nexperience\tO\ndemonstrates\tO\na\tO\npossible\tO\nrole\tO\nof\tO\nnaloxone\tB-Chemical\nin\tO\nthe\tO\nreversal\tO\nof\tO\nhypotension\tB-Disease\nresulting\tO\nfrom\tO\ncaptopril\tB-Chemical\n.\tO\n\nIdentification\tO\nof\tO\na\tO\nsimple\tO\nand\tO\nsensitive\tO\nmicroplate\tO\nmethod\tO\nfor\tO\nthe\tO\ndetection\tO\nof\tO\noversulfated\tO\nchondroitin\tB-Chemical\nsulfate\tI-Chemical\nin\tO\nheparin\tB-Chemical\nproducts\tO\n.\tO\n\nHeparin\tB-Chemical\nis\tO\na\tO\ncommonly\tO\nimplemented\tO\nanticoagulant\tO\nused\tO\nto\tO\ntreat\tO\ncritically\tO\nill\tO\npatients\tO\n.\tO\n\nRecently\tO\n,\tO\na\tO\nnumber\tO\nof\tO\ncommercial\tO\nlots\tO\nof\tO\nheparin\tB-Chemical\nproducts\tO\nwere\tO\nfound\tO\nto\tO\nbe\tO\ncontaminated\tO\nwith\tO\nan\tO\noversulfated\tO\nchondroitin\tB-Chemical\nsulfate\tI-Chemical\n(\tO\nOSCS\tO\n)\tO\nderivative\tO\nthat\tO\ncould\tO\nelicit\tO\na\tO\nhypotensive\tB-Disease\nresponse\tO\nin\tO\npigs\tO\nfollowing\tO\na\tO\nsingle\tO\nhigh\tO\n-\tO\ndose\tO\ninfusion\tO\n.\tO\n\nUsing\tO\nboth\tO\ncontaminated\tO\nheparin\tB-Chemical\nproducts\tO\nand\tO\nthe\tO\nsynthetically\tO\nproduced\tO\nderivative\tO\n,\tO\nwe\tO\nshowed\tO\nthat\tO\nthe\tO\nOSCS\tO\nproduces\tO\ndose\tO\n-\tO\ndependent\tO\nhypotension\tB-Disease\nin\tO\npigs\tO\n.\tO\n\nThe\tO\nno\tO\nobserved\tO\neffect\tO\nlevel\tO\n(\tO\nNOEL\tO\n)\tO\nfor\tO\nthis\tO\ncontaminant\tO\nappears\tO\nto\tO\nbe\tO\napproximately\tO\n1mg\tO\n/\tO\nkg\tO\n,\tO\ncorresponding\tO\nto\tO\na\tO\ncontamination\tO\nlevel\tO\nof\tO\napproximately\tO\n3\tO\n%\tO\n.\tO\n\nWe\tO\nalso\tO\ndemonstrated\tO\nthat\tO\nOSCS\tO\ncan\tO\nbe\tO\nidentified\tO\nin\tO\nheparin\tB-Chemical\nproducts\tO\nusing\tO\na\tO\nsimple\tO\n,\tO\ninexpensive\tO\n,\tO\ncommercially\tO\navailable\tO\nheparin\tB-Chemical\nenzyme\tO\nimmunoassay\tO\n(\tO\nEIA\tO\n)\tO\nkit\tO\nthat\tO\nhas\tO\na\tO\nlimit\tO\nof\tO\ndetection\tO\nof\tO\napproximately\tO\n0\tO\n.\tO\n1\tO\n%\tO\n,\tO\nwell\tO\nbelow\tO\nthe\tO\nNOEL\tO\n.\tO\n\nThis\tO\nkit\tO\nmay\tO\nprovide\tO\na\tO\nuseful\tO\nmethod\tO\nto\tO\ntest\tO\nheparin\tB-Chemical\nproducts\tO\nfor\tO\ncontamination\tO\nwith\tO\noversulfated\tO\nGAG\tO\nderivatives\tO\n.\tO\n\n5\tB-Chemical\nflourouracil\tI-Chemical\n-\tO\ninduced\tO\napical\tB-Disease\nballooning\tI-Disease\nsyndrome\tI-Disease\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nThe\tO\napical\tB-Disease\nballooning\tI-Disease\nsyndrome\tI-Disease\n(\tO\nABS\tB-Disease\n)\tO\nis\tO\na\tO\nrecently\tO\ndescribed\tO\nstress\tO\n-\tO\nmediated\tO\nacute\tB-Disease\ncardiac\tI-Disease\nsyndrome\tI-Disease\ncharacterized\tO\nby\tO\ntransient\tO\nwall\tO\n-\tO\nmotion\tO\nabnormalities\tO\ninvolving\tO\nthe\tO\napex\tO\nand\tO\nmidventricle\tO\nwith\tO\nhyperkinesis\tB-Disease\nof\tO\nthe\tO\nbasal\tO\nleft\tO\nventricular\tO\n(\tO\nLV\tO\n)\tO\nsegments\tO\nwithout\tO\nobstructive\tO\nepicardial\tB-Disease\ncoronary\tI-Disease\ndisease\tI-Disease\n.\tO\n\nCardiotoxicity\tB-Disease\nis\tO\nnot\tO\nan\tO\nuncommon\tO\nadverse\tO\neffect\tO\nof\tO\nchemotherapeutic\tO\nagents\tO\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nare\tO\nno\tO\nreports\tO\nof\tO\nABS\tB-Disease\nsecondary\tO\nto\tO\nchemotherapeutic\tO\nagents\tO\n.\tO\n\nWe\tO\ndescribe\tO\nthe\tO\ncase\tO\nof\tO\na\tO\nwoman\tO\nwho\tO\ndeveloped\tO\nthe\tO\nsyndrome\tO\nafter\tO\nchemotherapy\tO\nfor\tO\nmetastatic\tO\ncancer\tB-Disease\n.\tO\n\nA\tO\n79\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\npresented\tO\nwith\tO\ntypical\tO\nischemic\tB-Disease\nchest\tB-Disease\npain\tI-Disease\n,\tO\nelevated\tO\ncardiac\tO\nenzymes\tO\nwith\tO\nsignificant\tO\nST\tO\n-\tO\nsegment\tO\nabnormalities\tO\non\tO\nher\tO\nelectrocardiogram\tO\n.\tO\n\nShe\tO\nunderwent\tO\nrecent\tO\nchemotherapy\tO\nwith\tO\nfluorouracil\tB-Chemical\nfor\tO\nmetastatic\tO\ncolorectal\tB-Disease\ncancer\tI-Disease\n.\tO\n\nEchocardiography\tO\nrevealed\tO\na\tO\nwall\tO\n-\tO\nmotion\tO\nabnormality\tO\ninvolving\tO\nthe\tO\napical\tO\nand\tO\nperiapical\tO\nsegments\tO\nwhich\tO\nappeared\tO\nakinetic\tB-Disease\n.\tO\n\nCoronary\tO\nangiography\tO\nrevealed\tO\nno\tO\nobstructive\tO\ncoronary\tO\nlesions\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nstabilized\tO\nwith\tO\nmedical\tO\ntherapy\tO\n.\tO\n\nFour\tO\nweeks\tO\nlater\tO\nshe\tO\nremained\tO\ncompletely\tO\nasymptomatic\tO\n.\tO\n\nEchocardiogram\tO\nrevealed\tO\na\tO\nnormal\tO\nejection\tO\nfraction\tO\nand\tO\na\tO\nresolution\tO\nof\tO\nthe\tO\napical\tO\nakinesis\tB-Disease\n.\tO\n\nPathogenetic\tO\nmechanisms\tO\nof\tO\ncardiac\tB-Disease\ncomplications\tI-Disease\nin\tO\ncancer\tB-Disease\npatients\tO\nundergoing\tO\nchemotherapy\tO\ninclude\tO\ncoronary\tB-Disease\nvasospasm\tI-Disease\n,\tO\nendothelial\tO\ndamage\tO\nand\tO\nconsequent\tO\nthrombus\tB-Disease\nformation\tO\n.\tO\n\nIn\tO\nour\tO\npatient\tO\n,\tO\nboth\tO\nsupraphysiologic\tO\nlevels\tO\nof\tO\nplasma\tO\ncatecholamines\tB-Chemical\nand\tO\nstress\tO\nrelated\tO\nneuropeptides\tO\ncaused\tO\nby\tO\ncancer\tB-Disease\ndiagnosis\tO\nas\tO\nwell\tO\nas\tO\nchemotherapy\tO\nmay\tO\nhave\tO\ncontributed\tO\nthe\tO\ndevelopment\tO\nof\tO\nABS\tB-Disease\n.\tO\n\nRapid\tO\nreversal\tO\nof\tO\nanticoagulation\tO\nreduces\tO\nhemorrhage\tB-Disease\nvolume\tO\nin\tO\na\tO\nmouse\tO\nmodel\tO\nof\tO\nwarfarin\tB-Chemical\n-\tO\nassociated\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n.\tO\n\nWarfarin\tB-Chemical\n-\tO\nassociated\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n(\tO\nW\tO\n-\tO\nICH\tB-Disease\n)\tO\nis\tO\na\tO\nsevere\tO\ntype\tO\nof\tO\nstroke\tB-Disease\n.\tO\n\nThere\tO\nis\tO\nno\tO\nconsensus\tO\non\tO\nthe\tO\noptimal\tO\ntreatment\tO\nfor\tO\nW\tO\n-\tO\nICH\tB-Disease\n.\tO\n\nUsing\tO\na\tO\nmouse\tO\nmodel\tO\n,\tO\nwe\tO\ntested\tO\nwhether\tO\nthe\tO\nrapid\tO\nreversal\tO\nof\tO\nanticoagulation\tO\nusing\tO\nhuman\tO\nprothrombin\tB-Chemical\ncomplex\tI-Chemical\nconcentrate\tI-Chemical\n(\tO\nPCC\tB-Chemical\n)\tO\ncan\tO\nreduce\tO\nhemorrhagic\tO\nblood\tO\nvolume\tO\n.\tO\n\nMale\tO\nCD\tO\n-\tO\n1\tO\nmice\tO\nwere\tO\ntreated\tO\nwith\tO\nwarfarin\tB-Chemical\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nover\tO\n24\tO\nh\tO\n)\tO\n,\tO\nresulting\tO\nin\tO\na\tO\nmean\tO\n(\tO\n+\tO\n/\tO\n-\tO\ns\tO\n.\tO\nd\tO\n.\tO\n)\tO\nInternational\tO\nNormalized\tO\nRatio\tO\nof\tO\n3\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n9\tO\n.\tO\n\nFirst\tO\n,\tO\nwe\tO\nshowed\tO\nthat\tO\nan\tO\nintravenous\tO\nadministration\tO\nof\tO\nhuman\tO\nPCC\tB-Chemical\nrapidly\tO\nreversed\tO\nanticoagulation\tO\nin\tO\nmice\tO\n.\tO\n\nSecond\tO\n,\tO\na\tO\nstereotactic\tO\ninjection\tO\nof\tO\ncollagenase\tO\nwas\tO\nadministered\tO\nto\tO\ninduce\tO\nhemorrhage\tB-Disease\nin\tO\nthe\tO\nright\tO\nstriatum\tO\n.\tO\n\nForty\tO\n-\tO\nfive\tO\nminutes\tO\nlater\tO\n,\tO\nthe\tO\nanimals\tO\nwere\tO\nrandomly\tO\ntreated\tO\nwith\tO\nPCC\tB-Chemical\n(\tO\n100\tO\nU\tO\n/\tO\nkg\tO\n)\tO\nor\tO\nsaline\tO\ni\tO\n.\tO\nv\tO\n.\tO\n(\tO\nn\tO\n=\tO\n12\tO\nper\tO\ngroup\tO\n)\tO\n.\tO\n\nTwenty\tO\n-\tO\nfour\tO\nhours\tO\nafter\tO\nhemorrhage\tB-Disease\ninduction\tO\n,\tO\nhemorrhagic\tO\nblood\tO\nvolume\tO\nwas\tO\nquantified\tO\nusing\tO\na\tO\nphotometric\tO\nhemoglobin\tO\nassay\tO\n.\tO\n\nThe\tO\nmean\tO\nhemorrhagic\tO\nblood\tO\nvolume\tO\nwas\tO\nreduced\tO\nin\tO\nPCC\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\n(\tO\n6\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n1\tO\nmicroL\tO\n)\tO\ncompared\tO\nwith\tO\nsaline\tO\ncontrols\tO\n(\tO\n15\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n11\tO\n.\tO\n2\tO\nmicroL\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n015\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\nsaline\tO\ngroup\tO\n,\tO\n45\tO\n%\tO\nof\tO\nthe\tO\nmice\tO\ndeveloped\tO\nlarge\tO\nhematomas\tB-Disease\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\n>\tO\n15\tO\nmicroL\tO\n)\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nsuch\tO\nextensive\tO\nlesions\tO\nwere\tO\nnever\tO\nfound\tO\nin\tO\nthe\tO\nPCC\tB-Chemical\ngroup\tO\n.\tO\n\nWe\tO\nprovide\tO\nexperimental\tO\ndata\tO\nsuggesting\tO\nPCC\tB-Chemical\nto\tO\nbe\tO\nan\tO\neffective\tO\nacute\tO\ntreatment\tO\nfor\tO\nW\tO\n-\tO\nICH\tB-Disease\nin\tO\nterms\tO\nof\tO\nreducing\tO\nhemorrhagic\tO\nblood\tO\nvolume\tO\n.\tO\n\nFuture\tO\nstudies\tO\nare\tO\nneeded\tO\nto\tO\nassess\tO\nthe\tO\ntherapeutic\tO\npotential\tO\nemerging\tO\nfrom\tO\nour\tO\nfinding\tO\nfor\tO\nhuman\tO\nW\tO\n-\tO\nICH\tB-Disease\n.\tO\n\nLong\tO\nterm\tO\nhormone\tO\ntherapy\tO\nfor\tO\nperimenopausal\tO\nand\tO\npostmenopausal\tO\nwomen\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nHormone\tO\ntherapy\tO\n(\tO\nHT\tO\n)\tO\nis\tO\nwidely\tO\nused\tO\nfor\tO\ncontrolling\tO\nmenopausal\tO\nsymptoms\tO\nand\tO\nhas\tO\nalso\tO\nbeen\tO\nused\tO\nfor\tO\nthe\tO\nmanagement\tO\nand\tO\nprevention\tO\nof\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n,\tO\nosteoporosis\tB-Disease\nand\tO\ndementia\tB-Disease\nin\tO\nolder\tO\nwomen\tO\n.\tO\n\nThis\tO\nis\tO\nan\tO\nupdated\tO\nversion\tO\nof\tO\nthe\tO\noriginal\tO\nCochrane\tO\nreview\tO\nfirst\tO\npublished\tO\nin\tO\n2005\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nassess\tO\nthe\tO\neffect\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nHT\tO\non\tO\nmortality\tO\n,\tO\ncardiovascular\tO\noutcomes\tO\n,\tO\ncancer\tB-Disease\n,\tO\ngallbladder\tB-Disease\ndisease\tI-Disease\n,\tO\ncognition\tO\n,\tO\nfractures\tB-Disease\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nSEARCH\tO\nSTRATEGY\tO\n:\tO\nWe\tO\nsearched\tO\nthe\tO\nfollowing\tO\ndatabases\tO\nto\tO\nNovember\tO\n2007\tO\n:\tO\nTrials\tO\nRegister\tO\nof\tO\nthe\tO\nCochrane\tO\nMenstrual\tB-Disease\nDisorders\tI-Disease\nand\tO\nSubfertility\tO\nGroup\tO\n,\tO\nCochrane\tO\nCentral\tO\nRegister\tO\nof\tO\nControlled\tO\nTrials\tO\n,\tO\nMEDLINE\tO\n,\tO\nEMBASE\tO\n,\tO\nBiological\tO\nAbstracts\tO\n.\tO\n\nAlso\tO\nrelevant\tO\nnon\tO\n-\tO\nindexed\tO\njournals\tO\nand\tO\nconference\tO\nabstracts\tO\n.\tO\n\nSELECTION\tO\nCRITERIA\tO\n:\tO\nRandomised\tO\ndouble\tO\n-\tO\nblind\tO\ntrials\tO\nof\tO\nHT\tO\nversus\tO\nplacebo\tO\n,\tO\ntaken\tO\nfor\tO\nat\tO\nleast\tO\none\tO\nyear\tO\nby\tO\nperimenopausal\tO\nor\tO\npostmenopausal\tO\nwomen\tO\n.\tO\n\nHT\tO\nincluded\tO\noestrogens\tB-Chemical\n,\tO\nwith\tO\nor\tO\nwithout\tO\nprogestogens\tB-Chemical\n,\tO\nvia\tO\noral\tO\n,\tO\ntransdermal\tO\n,\tO\nsubcutaneous\tO\nor\tO\ntransnasal\tO\nroutes\tO\n.\tO\n\nDATA\tO\nCOLLECTION\tO\nAND\tO\nANALYSIS\tO\n:\tO\nTwo\tO\nauthors\tO\nindependently\tO\nassessed\tO\ntrial\tO\nquality\tO\nand\tO\nextracted\tO\ndata\tO\n.\tO\n\nMAIN\tO\nRESULTS\tO\n:\tO\nNineteen\tO\ntrials\tO\ninvolving\tO\n41\tO\n,\tO\n904\tO\nwomen\tO\nwere\tO\nincluded\tO\n.\tO\n\nIn\tO\nrelatively\tO\nhealthy\tO\nwomen\tO\n,\tO\ncombined\tO\ncontinuous\tO\nHT\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthrombo\tI-Disease\n-\tI-Disease\nembolism\tI-Disease\nor\tO\ncoronary\tO\nevent\tO\n(\tO\nafter\tO\none\tO\nyear\tO\n'\tO\ns\tO\nuse\tO\n)\tO\n,\tO\nstroke\tB-Disease\n(\tO\nafter\tO\nthree\tO\nyears\tO\n)\tO\n,\tO\nbreast\tB-Disease\ncancer\tI-Disease\nand\tO\ngallbladder\tB-Disease\ndisease\tI-Disease\n.\tO\n\nLong\tO\n-\tO\nterm\tO\noestrogen\tB-Chemical\n-\tO\nonly\tO\nHT\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthrombo\tI-Disease\n-\tI-Disease\nembolism\tI-Disease\n,\tO\nstroke\tB-Disease\nand\tO\ngallbladder\tB-Disease\ndisease\tI-Disease\n(\tO\nafter\tO\none\tO\nto\tO\ntwo\tO\nyears\tO\n,\tO\nthree\tO\nyears\tO\nand\tO\nseven\tO\nyears\tO\n'\tO\nuse\tO\nrespectively\tO\n)\tO\n,\tO\nbut\tO\ndid\tO\nnot\tO\nsignificantly\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nThe\tO\nonly\tO\nstatistically\tO\nsignificant\tO\nbenefits\tO\nof\tO\nHT\tO\nwere\tO\na\tO\ndecreased\tO\nincidence\tO\nof\tO\nfractures\tB-Disease\nand\tO\n(\tO\nfor\tO\ncombined\tO\nHT\tO\n)\tO\ncolon\tB-Disease\ncancer\tI-Disease\n,\tO\nwith\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\n.\tO\n\nAmong\tO\nwomen\tO\naged\tO\nover\tO\n65\tO\nwho\tO\nwere\tO\nrelatively\tO\nhealthy\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\ngenerally\tO\nfit\tO\n,\tO\nwithout\tO\novert\tO\ndisease\tO\n)\tO\nand\tO\ntaking\tO\ncontinuous\tO\ncombined\tO\nHT\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nstatistically\tO\nsignificant\tO\nincrease\tO\nin\tO\nthe\tO\nincidence\tO\nof\tO\ndementia\tB-Disease\n.\tO\n\nAmong\tO\nwomen\tO\nwith\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n,\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\ncombined\tO\ncontinuous\tO\nHT\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthrombo\tI-Disease\n-\tI-Disease\nembolism\tI-Disease\n.\tO\nOne\tO\ntrial\tO\nanalysed\tO\nsubgroups\tO\nof\tO\n2839\tO\nrelatively\tO\nhealthy\tO\n50\tO\nto\tO\n59\tO\nyear\tO\nold\tO\nwomen\tO\ntaking\tO\ncombined\tO\ncontinuous\tO\nHT\tO\nand\tO\n1637\tO\ntaking\tO\noestrogen\tB-Chemical\n-\tO\nonly\tO\nHT\tO\n,\tO\nversus\tO\nsimilar\tO\n-\tO\nsized\tO\nplacebo\tO\ngroups\tO\n.\tO\n\nThe\tO\nonly\tO\nsignificantly\tO\nincreased\tO\nrisk\tO\nreported\tO\nwas\tO\nfor\tO\nvenous\tB-Disease\nthrombo\tI-Disease\n-\tI-Disease\nembolism\tI-Disease\nin\tO\nwomen\tO\ntaking\tO\ncombined\tO\ncontinuous\tO\nHT\tO\n:\tO\ntheir\tO\nabsolute\tO\nrisk\tO\nremained\tO\nlow\tO\n,\tO\nat\tO\nless\tO\nthan\tO\n1\tO\n/\tO\n500\tO\n.\tO\n\nHowever\tO\n,\tO\nthis\tO\nstudy\tO\nwas\tO\nnot\tO\npowered\tO\nto\tO\ndetect\tO\ndifferences\tO\nbetween\tO\ngroups\tO\nof\tO\nyounger\tO\nwomen\tO\n.\tO\n\nAUTHORS\tO\n'\tO\nCONCLUSIONS\tO\n:\tO\nHT\tO\nis\tO\nnot\tO\nindicated\tO\nfor\tO\nthe\tO\nroutine\tO\nmanagement\tO\nof\tO\nchronic\tO\ndisease\tO\n.\tO\n\nWe\tO\nneed\tO\nmore\tO\nevidence\tO\non\tO\nthe\tO\nsafety\tO\nof\tO\nHT\tO\nfor\tO\nmenopausal\tO\nsymptom\tO\ncontrol\tO\n,\tO\nthough\tO\nshort\tO\n-\tO\nterm\tO\nuse\tO\nappears\tO\nto\tO\nbe\tO\nrelatively\tO\nsafe\tO\nfor\tO\nhealthy\tO\nyounger\tO\nwomen\tO\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nin\tO\npatients\tO\nwith\tO\nAIDS\tB-Disease\non\tO\ntenofovir\tB-Chemical\nwhile\tO\nreceiving\tO\nprolonged\tO\nvancomycin\tB-Chemical\ncourse\tO\nfor\tO\nosteomyelitis\tB-Disease\n.\tO\n\nRenal\tB-Disease\nfailure\tI-Disease\ndeveloped\tO\nafter\tO\na\tO\nprolonged\tO\ncourse\tO\nof\tO\nvancomycin\tB-Chemical\ntherapy\tO\nin\tO\n2\tO\npatients\tO\nwho\tO\nwere\tO\nreceiving\tO\ntenofovir\tB-Chemical\ndisoproxil\tI-Chemical\nfumarate\tI-Chemical\nas\tO\npart\tO\nof\tO\nan\tO\nantiretroviral\tO\nregimen\tO\n.\tO\n\nTenofovir\tB-Chemical\nhas\tO\nbeen\tO\nimplicated\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nFanconi\tB-Disease\nsyndrome\tI-Disease\nand\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\nbecause\tO\nof\tO\nits\tO\neffects\tO\non\tO\nthe\tO\nproximal\tO\nrenal\tO\ntubule\tO\n.\tO\n\nVancomycin\tB-Chemical\nnephrotoxicity\tB-Disease\nis\tO\ninfrequent\tO\nbut\tO\nmay\tO\nresult\tO\nfrom\tO\ncoadministration\tO\nwith\tO\na\tO\nnephrotoxic\tB-Disease\nagent\tO\n.\tO\n\nClinicians\tO\nshould\tO\nbe\tO\naware\tO\nthat\tO\ntenofovir\tB-Chemical\nmay\tO\nraise\tO\nthe\tO\nrisk\tO\nof\tO\nrenal\tB-Disease\nfailure\tI-Disease\nduring\tO\nprolonged\tO\nadministration\tO\nof\tO\nvancomycin\tB-Chemical\n.\tO\n\nRecurrent\tO\ndysosmia\tB-Disease\ninduced\tO\nby\tO\npyrazinamide\tB-Chemical\n.\tO\n\nPyrazinamide\tB-Chemical\ncan\tO\nhave\tO\nadverse\tO\neffects\tO\nsuch\tO\nas\tO\nhepatic\tB-Disease\ntoxicity\tI-Disease\n,\tO\nhyperuricemia\tB-Disease\nor\tO\ndigestive\tO\ndisorders\tO\n.\tO\n\nIn\tO\nrare\tO\ncases\tO\n,\tO\nalterations\tO\nin\tO\ntaste\tO\nand\tO\nsmell\tO\nfunction\tO\nhave\tO\nbeen\tO\nreported\tO\nfor\tO\npyrazinamide\tB-Chemical\nwhen\tO\ncombined\tO\nwith\tO\nother\tO\ndrugs\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nreversible\tO\nolfactory\tB-Disease\ndisorder\tI-Disease\nrelated\tO\nto\tO\npyrazinamide\tB-Chemical\nin\tO\na\tO\nwoman\tO\n,\tO\nwith\tO\na\tO\npositive\tO\nrechallenge\tO\n.\tO\n\nThe\tO\npatient\tO\npresented\tO\nevery\tO\nday\tO\na\tO\nsensation\tO\nof\tO\nsmelling\tO\nsomething\tO\nburning\tO\n15\tO\nmin\tO\nafter\tO\ndrug\tO\nintake\tO\n.\tO\n\nDysosmia\tB-Disease\ndisappeared\tO\ncompletely\tO\nafter\tO\npyrazinamide\tB-Chemical\nwithdrawal\tO\nand\tO\nrecurred\tO\nafter\tO\nits\tO\nrechallenge\tO\n.\tO\n\nThe\tO\ncase\tO\nwas\tO\nreported\tO\nto\tO\nthe\tO\nTunisian\tO\nCentre\tO\nof\tO\nPharmacovigilance\tO\n.\tO\n\nMice\tO\nlacking\tO\nmPGES\tO\n-\tO\n1\tO\nare\tO\nresistant\tO\nto\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\npolyuria\tB-Disease\n.\tO\n\nCyclooxygenase\tO\n-\tO\n2\tO\nactivity\tO\nis\tO\nrequired\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\npolyuria\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\ninvolvement\tO\nof\tO\na\tO\nspecific\tO\n,\tO\nterminal\tO\nprostaglandin\tB-Chemical\n(\tO\nPG\tB-Chemical\n)\tO\nisomerase\tO\nhas\tO\nnot\tO\nbeen\tO\nevaluated\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\nassess\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\npolyuria\tB-Disease\nin\tO\nmice\tO\ndeficient\tO\nin\tO\nmicrosomal\tO\nprostaglandin\tB-Chemical\nE\tI-Chemical\nsynthase\tO\n-\tO\n1\tO\n(\tO\nmPGES\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nA\tO\n2\tO\n-\tO\nwk\tO\nadministration\tO\nof\tO\nLiCl\tB-Chemical\n(\tO\n4\tO\nmmol\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\nday\tO\n(\tO\n-\tO\n1\tO\n)\tO\nip\tO\n)\tO\nin\tO\nmPGES\tO\n-\tO\n1\tO\n+\tO\n/\tO\n+\tO\nmice\tO\nled\tO\nto\tO\na\tO\nmarked\tO\npolyuria\tB-Disease\nwith\tO\nhyposmotic\tO\nurine\tO\n.\tO\n\nThis\tO\nwas\tO\nassociated\tO\nwith\tO\nelevated\tO\nrenal\tO\nmPGES\tO\n-\tO\n1\tO\nprotein\tO\nexpression\tO\nand\tO\nincreased\tO\nurine\tO\nPGE\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\nexcretion\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nmPGES\tO\n-\tO\n1\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nwere\tO\nlargely\tO\nresistant\tO\nto\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\npolyuria\tB-Disease\nand\tO\na\tO\nurine\tO\nconcentrating\tO\ndefect\tO\n,\tO\naccompanied\tO\nby\tO\nnearly\tO\ncomplete\tO\nblockade\tO\nof\tO\nhigh\tO\nurine\tO\nPGE\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\nand\tO\ncAMP\tO\noutput\tO\n.\tO\n\nImmunoblotting\tO\n,\tO\nimmunohistochemistry\tO\n,\tO\nand\tO\nquantitative\tO\n(\tO\nq\tO\n)\tO\nRT\tO\n-\tO\nPCR\tO\nconsistently\tO\ndetected\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\naquaporin\tO\n-\tO\n2\tO\n(\tO\nAQP2\tO\n)\tO\nprotein\tO\nexpression\tO\nin\tO\nboth\tO\nthe\tO\nrenal\tO\ncortex\tO\nand\tO\nmedulla\tO\nof\tO\nlithium\tB-Chemical\n-\tO\ntreated\tO\n+\tO\n/\tO\n+\tO\nmice\tO\n.\tO\n\nThis\tO\ndecrease\tO\nwas\tO\nsignificantly\tO\nattenuated\tO\nin\tO\nthe\tO\n-\tO\n/\tO\n-\tO\nmice\tO\n.\tO\n\nqRT\tO\n-\tO\nPCR\tO\ndetected\tO\nsimilar\tO\npatterns\tO\nof\tO\nchanges\tO\nin\tO\nAQP2\tO\nmRNA\tO\nin\tO\nthe\tO\nmedulla\tO\nbut\tO\nnot\tO\nin\tO\nthe\tO\ncortex\tO\n.\tO\n\nSimilarly\tO\n,\tO\nthe\tO\ntotal\tO\nprotein\tO\nabundance\tO\nof\tO\nthe\tO\nNa\tB-Chemical\n-\tO\nK\tB-Chemical\n-\tO\n2Cl\tB-Chemical\ncotransporter\tO\n(\tO\nNKCC2\tO\n)\tO\nin\tO\nthe\tO\nmedulla\tO\nbut\tO\nnot\tO\nin\tO\nthe\tO\ncortex\tO\nof\tO\nthe\tO\n+\tO\n/\tO\n+\tO\nmice\tO\nwas\tO\nsignificantly\tO\nreduced\tO\nby\tO\nlithium\tB-Chemical\ntreatment\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthe\tO\ndowregulation\tO\nof\tO\nrenal\tO\nmedullary\tO\nNKCC2\tO\nexpression\tO\nwas\tO\nsignificantly\tO\nattenuated\tO\nin\tO\nthe\tO\n-\tO\n/\tO\n-\tO\nmice\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nmPGES\tO\n-\tO\n1\tO\n-\tO\nderived\tO\nPGE\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\nmediates\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\npolyuria\tB-Disease\nlikely\tO\nvia\tO\ninhibition\tO\nof\tO\nAQP2\tO\nand\tO\nNKCC2\tO\nexpression\tO\n.\tO\n\nPreservation\tO\nof\tO\nrenal\tO\nblood\tO\nflow\tO\nduring\tO\nhypotension\tB-Disease\ninduced\tO\nwith\tO\nfenoldopam\tB-Chemical\nin\tO\ndogs\tO\n.\tO\n\nThe\tO\nintroduction\tO\nof\tO\ndrugs\tO\nthat\tO\ncould\tO\ninduce\tO\nhypotension\tB-Disease\nwith\tO\ndifferent\tO\npharmacological\tO\nactions\tO\nwould\tO\nbe\tO\nadvantageous\tO\nbecause\tO\nside\tO\neffects\tO\nunique\tO\nto\tO\na\tO\nspecific\tO\ndrug\tO\ncould\tO\nbe\tO\nminimized\tO\nby\tO\nselecting\tO\nappropriate\tO\ntherapy\tO\n.\tO\n\nSpecific\tO\ndopamine\tB-Chemical\n-\tO\n1\tO\n,\tO\n(\tO\nDA1\tB-Chemical\n)\tO\nand\tO\ndopamine\tB-Chemical\n-\tO\n2\tO\n(\tO\nDA2\tB-Chemical\n)\tO\nreceptor\tO\nagonists\tO\nare\tO\nnow\tO\nunder\tO\nclinical\tO\ninvestigation\tO\n.\tO\n\nFenoldopam\tB-Chemical\nmesylate\tI-Chemical\nis\tO\na\tO\nspecific\tO\nDA1\tO\nreceptor\tO\nagonist\tO\nthat\tO\nlowers\tO\nblood\tO\npressure\tO\nby\tO\nvasodilatation\tO\n.\tO\n\nThe\tO\nhypothesis\tO\nthat\tO\nfenoldopam\tB-Chemical\ncould\tO\nbe\tO\nused\tO\nto\tO\ninduce\tO\nhypotension\tB-Disease\nand\tO\npreserve\tO\nblood\tO\nflow\tO\nto\tO\nthe\tO\nkidney\tO\nwas\tO\ntested\tO\n.\tO\n\nSystemic\tO\naortic\tO\nblood\tO\npressure\tO\nand\tO\nrenal\tO\nblood\tO\nflow\tO\nwere\tO\nmeasured\tO\ncontinuously\tO\nwith\tO\na\tO\ncarotid\tO\narterial\tO\ncatheter\tO\nand\tO\nan\tO\nelectromagnetic\tO\nflow\tO\nprobe\tO\nrespectively\tO\n,\tO\nin\tO\norder\tO\nto\tO\ncompare\tO\nthe\tO\ncardiovascular\tO\nand\tO\nrenal\tO\nvascular\tO\neffects\tO\nof\tO\nfenoldopam\tB-Chemical\nand\tO\nsodium\tB-Chemical\nnitroprusside\tB-Chemical\nin\tO\nten\tO\ndogs\tO\nunder\tO\nhalothane\tB-Chemical\ngeneral\tO\nanaesthesia\tO\n.\tO\n\nMean\tO\narterial\tO\npressure\tO\nwas\tO\ndecreased\tO\n30\tO\n+\tO\n/\tO\n-\tO\n8\tO\nper\tO\ncent\tO\nfrom\tO\ncontrol\tO\nwith\tO\ninfusion\tO\nof\tO\nfenoldopam\tB-Chemical\n(\tO\n3\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n0\tO\nmicrograms\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nmin\tO\n-\tO\n1\tO\n)\tO\nand\tO\n34\tO\n+\tO\n/\tO\n-\tO\n4\tO\nper\tO\ncent\tO\nwith\tO\ninfusion\tO\nof\tO\nsodium\tB-Chemical\nnitroprusside\tB-Chemical\n(\tO\n5\tO\n.\tO\n9\tO\nmicrograms\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nmin\tO\n-\tO\n1\tO\n)\tO\n(\tO\nNS\tO\n)\tO\n.\tO\n\nRenal\tO\nblood\tO\nflow\tO\n(\tO\nRBF\tO\n)\tO\nincreased\tO\nduring\tO\nfenoldopam\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\n11\tO\n+\tO\n/\tO\n-\tO\n7\tO\nper\tO\ncent\tO\nand\tO\ndecreased\tO\n21\tO\n+\tO\n/\tO\n-\tO\n8\tO\nper\tO\ncent\tO\nduring\tO\nsodium\tB-Chemical\nnitroprusside\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nSodium\tO\nnitroprusside\tB-Chemical\nis\tO\na\tO\nnon\tO\n-\tO\nselective\tO\narteriolar\tO\nand\tO\nvenous\tO\nvasodilator\tO\nthat\tO\ncan\tO\nproduce\tO\nredistribution\tO\nof\tO\nblood\tO\nflow\tO\naway\tO\nfrom\tO\nthe\tO\nkidney\tO\nduring\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nFenoldopam\tO\nis\tO\na\tO\nselective\tO\ndopamine\tB-Chemical\n-\tO\n1\tO\n(\tO\nDA1\tO\n)\tO\nreceptor\tO\nagonist\tO\nthat\tO\ncauses\tO\nvasodilatation\tO\nto\tO\nthe\tO\nkidney\tO\nand\tO\nother\tO\norgans\tO\nwith\tO\nDA1\tO\nreceptors\tO\nand\tO\npreserves\tO\nblood\tO\nflow\tO\nto\tO\nthe\tO\nkidney\tO\nduring\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nSeizures\tB-Disease\nassociated\tO\nwith\tO\nlevofloxacin\tB-Chemical\n:\tO\ncase\tO\npresentation\tO\nand\tO\nliterature\tO\nreview\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nWe\tO\npresent\tO\na\tO\ncase\tO\nof\tO\na\tO\npatient\tO\nwho\tO\ndeveloped\tO\nseizures\tB-Disease\nshortly\tO\nafter\tO\ninitiating\tO\ntreatment\tO\nwith\tO\nlevofloxacin\tB-Chemical\nand\tO\nto\tO\ndiscuss\tO\nthe\tO\npotential\tO\ndrug\tO\n-\tO\ndrug\tO\ninteractions\tO\nrelated\tO\nto\tO\nthe\tO\ninhibition\tO\nof\tO\ncytochrome\tO\nP450\tO\n(\tO\nCYP\tO\n)\tO\n1A2\tO\nin\tO\nthis\tO\ncase\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nin\tO\nother\tO\ncases\tO\n,\tO\nof\tO\nlevofloxacin\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nSeveral\tO\nbiomedical\tO\ndatabases\tO\nwere\tO\nsearched\tO\nincluding\tO\nMEDLINE\tO\n,\tO\nCochrane\tO\nand\tO\nOvid\tO\n.\tO\n\nThe\tO\nmain\tO\nsearch\tO\nterms\tO\nutilized\tO\nwere\tO\ncase\tO\nreport\tO\nand\tO\nlevofloxacin\tB-Chemical\n.\tO\n\nThe\tO\nsearch\tO\nwas\tO\nlimited\tO\nto\tO\nstudies\tO\npublished\tO\nin\tO\nEnglish\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSix\tO\ncases\tO\nof\tO\nlevofloxacin\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nhave\tO\nbeen\tO\nreported\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nDrug\tO\n-\tO\ndrug\tO\ninteractions\tO\nrelated\tO\nto\tO\nthe\tO\ninhibition\tO\nof\tO\nCYP1A2\tO\nby\tO\nlevofloxacin\tB-Chemical\nare\tO\nlikely\tO\ninvolved\tO\nin\tO\nthe\tO\nclinical\tO\noutcome\tO\nof\tO\nthese\tO\ncases\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nClinicians\tO\nare\tO\nexhorted\tO\nto\tO\npay\tO\nclose\tO\nattention\tO\nwhen\tO\ninitiating\tO\nlevofloxacin\tB-Chemical\ntherapy\tO\nin\tO\npatients\tO\ntaking\tO\nmedications\tO\nwith\tO\nepileptogenic\tO\nproperties\tO\nthat\tO\nare\tO\nCYP1A2\tO\nsubstrates\tO\n.\tO\n\nDextran\tB-Chemical\n-\tO\netodolac\tB-Chemical\nconjugates\tO\n:\tO\nsynthesis\tO\n,\tO\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\nevaluation\tO\n.\tO\n\nEtodolac\tB-Chemical\n(\tO\nE\tB-Chemical\n)\tO\n,\tO\nis\tO\na\tO\nnon\tO\n-\tO\nnarcotic\tO\nanalgesic\tO\nand\tO\nantiinflammatory\tO\ndrug\tO\n.\tO\n\nA\tO\nbiodegradable\tO\npolymer\tO\ndextran\tB-Chemical\nhas\tO\nbeen\tO\nutilized\tO\nas\tO\na\tO\ncarrier\tO\nfor\tO\nsynthesis\tO\nof\tO\netodolac\tB-Chemical\n-\tO\ndextran\tB-Chemical\nconjugates\tO\n(\tO\nED\tO\n)\tO\nto\tO\nimprove\tO\nits\tO\naqueous\tO\nsolubility\tO\nand\tO\nreduce\tO\ngastrointestinal\tO\nside\tO\neffects\tO\n.\tO\n\nAn\tO\nactivated\tO\nmoiety\tO\n,\tO\ni\tO\n.\tO\ne\tO\n.\tO\nN\tB-Chemical\n-\tI-Chemical\nacylimidazole\tI-Chemical\nderivative\tO\nof\tO\netodolac\tB-Chemical\n(\tO\nEAI\tB-Chemical\n)\tO\n,\tO\nwas\tO\ncondensed\tO\nwith\tO\nthe\tO\npolysaccharide\tO\npolymer\tO\ndextran\tB-Chemical\nof\tO\ndifferent\tO\nmolecular\tO\nweights\tO\n(\tO\n40000\tO\n,\tO\n60000\tO\n,\tO\n110000\tO\nand\tO\n200000\tO\n)\tO\n.\tO\n\nIR\tO\nspectral\tO\ndata\tO\nconfirmed\tO\nformation\tO\nof\tO\nester\tO\nbonding\tO\nin\tO\nthe\tO\nconjugates\tO\n.\tO\n\nEtodolac\tB-Chemical\ncontents\tO\nwere\tO\nevaluated\tO\nby\tO\nUV\tO\n-\tO\nspectrophotometric\tO\nanalysis\tO\n.\tO\n\nThe\tO\nmolecular\tO\nweights\tO\nwere\tO\ndetermined\tO\nby\tO\nmeasuring\tO\nviscosity\tO\nusing\tO\nthe\tO\nMark\tO\n-\tO\nHowink\tO\n-\tO\nSakurada\tO\nequation\tO\n.\tO\n\nIn\tO\nvitro\tO\nhydrolysis\tO\nof\tO\nED\tO\nwas\tO\ndone\tO\nin\tO\naqueous\tO\nbuffers\tO\n(\tO\npH\tO\n1\tO\n.\tO\n2\tO\n,\tO\n7\tO\n.\tO\n4\tO\n,\tO\n9\tO\n)\tO\nand\tO\nin\tO\n80\tO\n%\tO\n(\tO\nv\tO\n/\tO\nv\tO\n)\tO\nhuman\tO\nplasma\tO\n(\tO\npH\tO\n7\tO\n.\tO\n4\tO\n)\tO\n.\tO\n\nAt\tO\npH\tO\n9\tO\n,\tO\na\tO\nhigher\tO\nrate\tO\nof\tO\netodolac\tB-Chemical\nrelease\tO\nfrom\tO\nED\tO\nwas\tO\nobserved\tO\nas\tO\ncompared\tO\nto\tO\naqueous\tO\nbuffer\tO\nof\tO\npH\tO\n7\tO\n.\tO\n4\tO\nand\tO\n80\tO\n%\tO\nhuman\tO\nplasma\tO\n(\tO\npH\tO\n7\tO\n.\tO\n4\tO\n)\tO\n,\tO\nfollowing\tO\nfirst\tO\n-\tO\norder\tO\nkinetics\tO\n.\tO\n\nIn\tO\nvivo\tO\ninvestigations\tO\nwere\tO\nperformed\tO\nin\tO\nanimals\tO\n.\tO\n\nAcute\tO\nanalgesic\tO\nand\tO\nantiinflammatory\tO\nactivities\tO\nwere\tO\nascertained\tO\nusing\tO\nacetic\tB-Chemical\nacid\tI-Chemical\ninduced\tO\nwrithing\tB-Disease\nmodel\tO\n(\tO\nmice\tO\n)\tO\nand\tO\ncarrageenan\tB-Chemical\n-\tO\ninduced\tO\nrat\tO\npaw\tO\nedema\tB-Disease\nmodel\tO\n,\tO\nrespectively\tO\n.\tO\n\nIn\tO\ncomparison\tO\nto\tO\ncontrol\tO\n,\tO\nE\tB-Chemical\nand\tO\nED1\tO\n-\tO\nED4\tO\nshowed\tO\nhighly\tO\nsignificant\tO\nanalgesic\tO\nand\tO\nantiinflammatory\tO\nactivities\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nBiological\tO\nevaluation\tO\nsuggested\tO\nthat\tO\nconjugates\tO\n(\tO\nED1\tO\n-\tO\nED4\tO\n)\tO\nretained\tO\ncomparable\tO\nanalgesic\tO\nand\tO\nantiinflammatory\tO\nactivities\tO\nwith\tO\nremarkably\tO\nreduced\tO\nulcerogenicity\tO\nas\tO\ncompared\tO\nto\tO\ntheir\tO\nparent\tO\ndrug\tO\n-\tO\n-\tO\netodolac\tB-Chemical\n.\tO\n\nThe\tO\nantiarrhythmic\tO\neffect\tO\nand\tO\npossible\tO\nionic\tO\nmechanisms\tO\nof\tO\npilocarpine\tB-Chemical\non\tO\nanimal\tO\nmodels\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\nthe\tO\neffects\tO\nof\tO\npilocarpine\tB-Chemical\nand\tO\nexplore\tO\nthe\tO\nunderlying\tO\nionic\tO\nmechanism\tO\n,\tO\nusing\tO\nboth\tO\naconitine\tB-Chemical\n-\tO\ninduced\tO\nrat\tO\nand\tO\nouabain\tB-Chemical\n-\tO\ninduced\tO\nguinea\tO\npig\tO\narrhythmia\tB-Disease\nmodels\tO\n.\tO\n\nConfocal\tO\nmicroscopy\tO\nwas\tO\nused\tO\nto\tO\nmeasure\tO\nintracellular\tO\nfree\tO\n-\tO\ncalcium\tB-Chemical\nconcentrations\tO\n(\tO\n[\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\n]\tO\n(\tO\ni\tO\n)\tO\n)\tO\nin\tO\nisolated\tO\nmyocytes\tO\n.\tO\n\nThe\tO\ncurrent\tO\ndata\tO\nshowed\tO\nthat\tO\npilocarpine\tB-Chemical\nsignificantly\tO\ndelayed\tO\nonset\tO\nof\tO\narrhythmias\tB-Disease\n,\tO\ndecreased\tO\nthe\tO\ntime\tO\ncourse\tO\nof\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nand\tI-Disease\nfibrillation\tI-Disease\n,\tO\nreduced\tO\narrhythmia\tB-Disease\nscore\tO\n,\tO\nand\tO\nincreased\tO\nthe\tO\nsurvival\tO\ntime\tO\nof\tO\narrhythmic\tB-Disease\nrats\tO\nand\tO\nguinea\tO\npigs\tO\n.\tO\n\n[\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\n]\tO\n(\tO\ni\tO\n)\tO\noverload\tO\ninduced\tO\nby\tO\naconitine\tB-Chemical\nor\tO\nouabain\tB-Chemical\nwas\tO\nreduced\tO\nin\tO\nisolated\tO\nmyocytes\tO\npretreated\tO\nwith\tO\npilocarpine\tB-Chemical\n.\tO\n\nMoreover\tO\n,\tO\nM\tO\n(\tO\n3\tO\n)\tO\n-\tO\nmuscarinic\tO\nacetylcholine\tB-Chemical\nreceptor\tO\n(\tO\nmAChR\tO\n)\tO\nantagonist\tO\n4\tB-Chemical\n-\tI-Chemical\nDAMP\tI-Chemical\n(\tO\n4\tB-Chemical\n-\tI-Chemical\ndiphenylacetoxy\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\nmethylpiperidine\tI-Chemical\n-\tI-Chemical\nmethiodide\tI-Chemical\n)\tO\npartially\tO\nabolished\tO\nthe\tO\nbeneficial\tO\neffects\tO\nof\tO\npilocarpine\tB-Chemical\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\npilocarpine\tB-Chemical\nproduced\tO\nantiarrhythmic\tO\nactions\tO\non\tO\narrhythmic\tB-Disease\nrat\tO\nand\tO\nguinea\tO\npig\tO\nmodels\tO\ninduced\tO\nby\tO\naconitine\tB-Chemical\nor\tO\nouabain\tB-Chemical\nvia\tO\nstimulating\tO\nthe\tO\ncardiac\tO\nM\tO\n(\tO\n3\tO\n)\tO\n-\tO\nmAChR\tO\n.\tO\n\nThe\tO\nmechanism\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nthe\tO\nimprovement\tO\nof\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nhandling\tO\n.\tO\n\nEffect\tO\nof\tO\nHibiscus\tB-Chemical\nrosa\tI-Chemical\nsinensis\tI-Chemical\non\tO\nreserpine\tB-Chemical\n-\tO\ninduced\tO\nneurobehavioral\tO\nand\tO\nbiochemical\tO\nalterations\tO\nin\tO\nrats\tO\n.\tO\n\nEffect\tO\nof\tO\nmethanolic\tO\nextract\tO\nof\tO\nHibiscus\tB-Chemical\nrosa\tI-Chemical\nsinensis\tI-Chemical\n(\tO\n100\tO\n-\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\nstudied\tO\non\tO\nreserpine\tB-Chemical\n-\tO\ninduced\tO\norofacial\tO\ndyskinesia\tB-Disease\nand\tO\nneurochemical\tO\nalterations\tO\n.\tO\n\nThe\tO\nrats\tO\nwere\tO\ntreated\tO\nwith\tO\nintraperitoneal\tO\nreserpine\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nip\tO\n)\tO\nfor\tO\n3\tO\ndays\tO\nevery\tO\nother\tO\nday\tO\n.\tO\n\nOn\tO\nday\tO\n5\tO\n,\tO\nvacuous\tO\nchewing\tO\nmovements\tO\nand\tO\ntongue\tO\nprotrusions\tO\nwere\tO\ncounted\tO\nfor\tO\n5\tO\nmin\tO\n.\tO\n\nReserpine\tB-Chemical\ntreated\tO\nrats\tO\nsignificantly\tO\ndeveloped\tO\nvacuous\tO\nchewing\tO\nmovements\tO\nand\tO\ntongue\tO\nprotrusions\tO\nhowever\tO\n,\tO\ncoadministration\tO\nof\tO\nHibiscus\tB-Chemical\nrosa\tI-Chemical\nsinensis\tI-Chemical\nroots\tO\nextract\tO\n(\tO\n100\tO\n,\tO\n200\tO\nand\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nper\tO\norally\tO\n)\tO\nattenuated\tO\nthe\tO\neffects\tO\n.\tO\n\nBiochemical\tO\nanalysis\tO\nof\tO\nbrain\tO\nrevealed\tO\nthat\tO\nthe\tO\nreserpine\tB-Chemical\ntreatment\tO\nsignificantly\tO\nincreased\tO\nlipid\tO\nperoxidation\tO\nand\tO\ndecreased\tO\nlevels\tO\nof\tO\nsuperoxide\tB-Chemical\ndismutase\tO\n(\tO\nSOD\tO\n)\tO\n,\tO\ncatalase\tO\n(\tO\nCAT\tO\n)\tO\nand\tO\nglutathione\tB-Chemical\nreductase\tO\n(\tO\nGSH\tO\n)\tO\n,\tO\nan\tO\nindex\tO\nof\tO\noxidative\tO\nstress\tO\nprocess\tO\n.\tO\n\nCoadministration\tO\nof\tO\nextract\tO\nsignificantly\tO\nreduced\tO\nthe\tO\nlipid\tO\nperoxidation\tO\nand\tO\nreversed\tO\nthe\tO\ndecrease\tO\nin\tO\nbrain\tO\nSOD\tO\n,\tO\nCAT\tO\nand\tO\nGSH\tO\nlevels\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nsuggested\tO\nthat\tO\nHibiscus\tB-Chemical\nrosa\tI-Chemical\nsinensis\tI-Chemical\nhad\tO\na\tO\nprotective\tO\nrole\tO\nagainst\tO\nreserpine\tB-Chemical\n-\tO\ninduced\tO\norofacial\tO\ndyskinesia\tB-Disease\nand\tO\noxidative\tO\nstress\tO\n.\tO\n\nDynamic\tO\nresponse\tO\nof\tO\nblood\tO\nvessel\tO\nin\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\nwe\tO\npostulated\tO\nthat\tO\nduring\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\ninduced\tO\nby\tO\ngentamicin\tB-Chemical\nthe\tO\ntransient\tO\nor\tO\ndynamic\tO\nresponse\tO\nof\tO\nblood\tO\nvessels\tO\ncould\tO\nbe\tO\naffected\tO\n,\tO\nand\tO\nthat\tO\nantioxidants\tO\ncan\tO\nprevent\tO\nthe\tO\nchanges\tO\nin\tO\ndynamic\tO\nresponses\tO\nof\tO\nblood\tO\nvessels\tO\n.\tO\n\nThe\tO\nnew\tO\napproach\tO\nto\tO\nex\tO\nvivo\tO\nblood\tO\nvessel\tO\nexperiments\tO\nin\tO\nwhich\tO\nnot\tO\nonly\tO\nthe\tO\nend\tO\npoints\tO\nof\tO\nvessels\tO\nresponse\tO\nwithin\tO\nthe\tO\ntime\tO\ninterval\tO\nis\tO\nconsidered\tO\n,\tO\nbut\tO\nalso\tO\ndynamics\tO\nof\tO\nthis\tO\nresponse\tO\n,\tO\nwas\tO\nused\tO\nin\tO\nthis\tO\npaper\tO\n.\tO\n\nOur\tO\nresults\tO\nconfirm\tO\nthe\tO\nalteration\tO\nin\tO\ndynamic\tO\nresponse\tO\nof\tO\nblood\tO\nvessels\tO\nduring\tO\nthe\tO\nchange\tO\nof\tO\npressure\tO\nin\tO\ngentamicin\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\n.\tO\n\nThe\tO\nbeneficial\tO\neffects\tO\nof\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nadministration\tO\nto\tO\ngentamicin\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\nare\tO\nalso\tO\nconfirmed\tO\nthrough\tO\n:\tO\nlower\tO\nlevel\tO\nof\tO\nblood\tO\nurea\tB-Chemical\nand\tO\ncreatinine\tB-Chemical\nand\tO\nhigher\tO\nlevel\tO\nof\tO\npotassium\tB-Chemical\n.\tO\n\nThe\tO\npressure\tO\ndynamic\tO\nresponses\tO\nof\tO\nisolated\tO\nblood\tO\nvessels\tO\nshow\tO\na\tO\nfaster\tO\npressure\tO\nchange\tO\nin\tO\ngentamicin\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\n(\tO\n8\tO\n.\tO\n07\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n7\tO\ns\tO\nvs\tO\n.\tO\n5\tO\n.\tO\n64\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n18\tO\ns\tO\n)\tO\n.\tO\n\nVitamin\tB-Chemical\nC\tI-Chemical\nadministration\tO\ninduced\tO\nslowdown\tO\nof\tO\npressure\tO\nchange\tO\nback\tO\nto\tO\nthe\tO\ncontrol\tO\nvalues\tO\n.\tO\n\nThe\tO\npressure\tO\ndynamic\tO\nproperties\tO\n,\tO\nquantitatively\tO\ndefined\tO\nby\tO\ncomparative\tO\npressure\tO\ndynamic\tO\nand\tO\ntotal\tO\npressure\tO\ndynamic\tO\n,\tO\nconfirm\tO\nthe\tO\nalteration\tO\nin\tO\ndynamic\tO\nresponse\tO\nof\tO\nblood\tO\nvessels\tO\nduring\tO\nthe\tO\nchange\tO\nof\tO\npressure\tO\nin\tO\ngentamicin\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\nand\tO\nbeneficial\tO\neffects\tO\nof\tO\nvitamin\tB-Chemical\nC\tI-Chemical\nadministration\tO\n.\tO\n\nReversible\tO\nmyocardial\tB-Disease\nhypertrophy\tI-Disease\ninduced\tO\nby\tO\ntacrolimus\tB-Chemical\nin\tO\na\tO\npediatric\tO\nheart\tO\ntransplant\tO\nrecipient\tO\n:\tO\ncase\tO\nreport\tO\n.\tO\n\nTacrolimus\tB-Chemical\nis\tO\na\tO\npotent\tO\nimmunosuppressant\tO\nthat\tO\nis\tO\nfrequently\tO\nused\tO\nin\tO\norgan\tO\ntransplantation\tO\n.\tO\n\nHowever\tO\n,\tO\nadverse\tO\neffects\tO\ninclude\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nHerein\tO\nwe\tO\ndescribe\tO\ntransient\tO\nmyocardial\tB-Disease\nhypertrophy\tI-Disease\ninduced\tO\nby\tO\ntacrolimus\tB-Chemical\nafter\tO\nheart\tO\ntransplantation\tO\n.\tO\n\nThe\tO\nhypertrophy\tB-Disease\ncaused\tO\nno\tO\nclinical\tO\nsymptoms\tO\nbut\tO\nwas\tO\nnoted\tO\nbecause\tO\nof\tO\nelevation\tO\nof\tO\nplasma\tO\nbrain\tO\nnatriuretic\tO\npeptide\tO\nconcentration\tO\nand\tO\nconfirmed\tO\nat\tO\nechocardiography\tO\n.\tO\n\nInitially\tO\n,\tO\nallograft\tO\nrejection\tO\nwas\tO\nfeared\tO\n;\tO\nhowever\tO\n,\tO\nmyocardial\tO\nbiopsy\tO\nsamples\tO\nrevealed\tO\nonly\tO\ninterstitial\tO\nedema\tB-Disease\nand\tO\nmild\tO\nmyocardial\tB-Disease\nhypertrophy\tI-Disease\n;\tO\nneither\tO\ncellular\tO\nnor\tO\nhumoral\tO\nrejection\tO\nwas\tO\ndetected\tO\n.\tO\n\nThe\tO\nblood\tO\ntacrolimus\tB-Chemical\nconcentration\tO\nwas\tO\nhigher\tO\nthan\tO\nusual\tO\nat\tO\nthat\tO\ntime\tO\n;\tO\nthus\tO\n,\tO\ntacrolimus\tB-Chemical\ndosage\tO\nwas\tO\nreduced\tO\n.\tO\n\nMyocardial\tB-Disease\nhypertrophy\tI-Disease\ncompletely\tO\nresolved\tO\nupon\tO\nreducing\tO\nthe\tO\ntarget\tO\nconcentration\tO\nof\tO\ntacrolimus\tB-Chemical\nand\tO\ndid\tO\nnot\tO\nrecur\tO\n,\tO\nas\tO\nconfirmed\tO\nat\tO\nechocardiography\tO\nand\tO\nmyocardial\tO\nbiopsy\tO\n.\tO\n\nThus\tO\n,\tO\nwe\tO\nconclude\tO\nthat\tO\ntacrolimus\tB-Chemical\ninduces\tO\nreversible\tO\nmyocardial\tB-Disease\nhypertrophy\tI-Disease\n.\tO\n\nIn\tO\npatients\tO\nreceiving\tO\ntacrolimus\tB-Chemical\ntherapy\tO\n,\tO\nblood\tO\nconcentration\tO\nshould\tO\nbe\tO\ncarefully\tO\ncontrolled\tO\nand\tO\nextreme\tO\nattention\tO\npaid\tO\nto\tO\ncardiac\tO\ninvolvement\tO\n.\tO\n\nNimodipine\tB-Chemical\nprevents\tO\nmemory\tB-Disease\nimpairment\tI-Disease\ncaused\tO\nby\tO\nnitroglycerin\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nin\tO\nadult\tO\nmice\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nHypotension\tB-Disease\nand\tO\na\tO\nresultant\tO\ndecrease\tO\nin\tO\ncerebral\tO\nblood\tO\nflow\tO\nhave\tO\nbeen\tO\nimplicated\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\ncognitive\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nWe\tO\ntested\tO\nthe\tO\nhypothesis\tO\nthat\tO\nnimodipine\tB-Chemical\n(\tO\nNIMO\tB-Chemical\n)\tO\nadministered\tO\nat\tO\nthe\tO\nonset\tO\nof\tO\nnitroglycerin\tB-Chemical\n(\tO\nNTG\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\nwould\tO\npreserve\tO\nlong\tO\n-\tO\nterm\tO\nassociative\tO\nmemory\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\npassive\tO\navoidance\tO\n(\tO\nPA\tO\n)\tO\nparadigm\tO\nwas\tO\nused\tO\nto\tO\nassess\tO\nmemory\tO\nretention\tO\n.\tO\n\nFor\tO\nPA\tO\ntraining\tO\n,\tO\nlatencies\tO\n(\tO\nseconds\tO\n)\tO\nwere\tO\nrecorded\tO\nfor\tO\nentry\tO\nfrom\tO\na\tO\nsuspended\tO\nplatform\tO\ninto\tO\na\tO\nPlexiglas\tO\ntube\tO\nwhere\tO\na\tO\nshock\tO\nwas\tO\nautomatically\tO\ndelivered\tO\n.\tO\n\nLatencies\tO\nwere\tO\nrecorded\tO\n48\tO\nh\tO\nlater\tO\nfor\tO\na\tO\ntesting\tO\ntrial\tO\n.\tO\n\nNinety\tO\n-\tO\nsix\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n(\tO\n30\tO\n-\tO\n35\tO\ng\tO\n,\tO\n6\tO\n-\tO\n8\tO\nwk\tO\n)\tO\n,\tO\nwere\tO\nrandomized\tO\ninto\tO\n6\tO\ngroups\tO\n1\tO\n)\tO\nsaline\tO\n(\tO\ncontrol\tO\n)\tO\n,\tO\n2\tO\n)\tO\nNTG\tB-Chemical\nimmediately\tO\nafter\tO\nlearning\tO\n,\tO\n3\tO\n)\tO\nNTG\tB-Chemical\n3\tO\nh\tO\nafter\tO\nlearning\tO\n,\tO\n4\tO\n)\tO\nNTG\tB-Chemical\nand\tO\nNIMO\tB-Chemical\n,\tO\n5\tO\n)\tO\nvehicle\tO\n,\tO\nand\tO\n6\tO\n)\tO\nNIMO\tB-Chemical\nalone\tO\n.\tO\n\nThe\tO\nextent\tO\nof\tO\nhypotension\tB-Disease\nand\tO\nchanges\tO\nin\tO\nbrain\tO\ntissue\tO\noxygenation\tO\n(\tO\nPbtO\tO\n(\tO\n2\tO\n)\tO\n)\tO\nand\tO\nin\tO\ncerebral\tO\nblood\tO\nflow\tO\nwere\tO\nstudied\tO\nin\tO\na\tO\nseparate\tO\ngroup\tO\nof\tO\nanimals\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\ngroups\tO\nexhibited\tO\nsimilar\tO\ntraining\tO\nlatencies\tO\n(\tO\n17\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n6\tO\ns\tO\n)\tO\n.\tO\n\nMice\tO\nsubjected\tO\nto\tO\nhypotensive\tB-Disease\nepisodes\tO\nshowed\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nlatency\tO\ntime\tO\n(\tO\n178\tO\n+\tO\n/\tO\n-\tO\n156\tO\ns\tO\n)\tO\ncompared\tO\nwith\tO\nthose\tO\ninjected\tO\nwith\tO\nsaline\tO\n,\tO\nNTG\tB-Chemical\n+\tO\nNIMO\tB-Chemical\n,\tO\nor\tO\ndelayed\tO\nNTG\tB-Chemical\n(\tO\n580\tO\n+\tO\n/\tO\n-\tO\n81\tO\ns\tO\n,\tO\n557\tO\n+\tO\n/\tO\n-\tO\n67\tO\ns\tO\n,\tO\nand\tO\n493\tO\n+\tO\n/\tO\n-\tO\n146\tO\ns\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nA\tO\nKruskal\tO\n-\tO\nWallis\tO\n1\tO\n-\tO\nway\tO\nanalysis\tO\nof\tO\nvariance\tO\nindicated\tO\na\tO\nsignificant\tO\ndifference\tO\namong\tO\nthe\tO\n4\tO\ntreatment\tO\ngroups\tO\n(\tO\nH\tO\n=\tO\n15\tO\n.\tO\n34\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nIn\tO\na\tO\nseparate\tO\ngroup\tO\nof\tO\nmice\tO\nnot\tO\nsubjected\tO\nto\tO\nbehavioral\tO\nstudies\tO\n,\tO\nthe\tO\nsame\tO\ndose\tO\nof\tO\nNTG\tB-Chemical\n(\tO\nn\tO\n=\tO\n3\tO\n)\tO\nand\tO\nNTG\tB-Chemical\n+\tO\nNIMO\tB-Chemical\n(\tO\nn\tO\n=\tO\n3\tO\n)\tO\ncaused\tO\nmean\tO\narterial\tO\nblood\tO\npressure\tO\nto\tO\ndecrease\tO\nfrom\tO\n85\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n8\tO\nmm\tO\nHg\tO\nsem\tO\nto\tO\n31\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n8\tO\nmm\tO\nHg\tO\nsem\tO\nand\tO\nfrom\tO\n86\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n7\tO\nmm\tO\nHg\tO\nsem\tO\nto\tO\n32\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nmm\tO\nHg\tO\nsem\tO\n,\tO\nrespectively\tO\n.\tO\n\nMean\tO\narterial\tO\nblood\tO\npressure\tO\nin\tO\nmice\tO\ntreated\tO\nwith\tO\nNIMO\tB-Chemical\nalone\tO\ndecreased\tO\nfrom\tO\n88\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n8\tO\nmm\tO\nHg\tO\nto\tO\n80\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n9\tO\nmm\tO\nHg\tO\n.\tO\n\nThe\tO\nintergroup\tO\ndifference\tO\nwas\tO\nstatistically\tO\nsignificant\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nPbtO\tO\n(\tO\n2\tO\n)\tO\ndecreased\tO\nfrom\tO\n51\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n5\tO\nmm\tO\nHg\tO\nsem\tO\nto\tO\n33\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n2\tO\nmm\tO\nHg\tO\nsem\tO\nin\tO\nthe\tO\nNTG\tB-Chemical\ngroup\tO\nand\tO\nfrom\tO\n38\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n1\tO\nmm\tO\nHg\tO\nsem\tO\nto\tO\n25\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n0\tO\nmm\tO\nHg\tO\nsem\tO\nin\tO\nthe\tO\nNTG\tB-Chemical\n+\tO\nNIMO\tB-Chemical\ngroups\tO\n,\tO\nrespectively\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nsignificant\tO\ndifferences\tO\namong\tO\ngroups\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\na\tO\nPA\tO\nretention\tO\nparadigm\tO\n,\tO\nthe\tO\ninjection\tO\nof\tO\nNTG\tB-Chemical\nimmediately\tO\nafter\tO\nlearning\tO\nproduced\tO\na\tO\nsignificant\tO\nimpairment\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nassociative\tO\nmemory\tO\nin\tO\nmice\tO\n,\tO\nwhereas\tO\ndelayed\tO\ninduced\tO\nhypotension\tB-Disease\nhad\tO\nno\tO\neffect\tO\n.\tO\n\nNIMO\tB-Chemical\nattenuated\tO\nthe\tO\ndisruption\tO\nin\tO\nconsolidation\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nmemory\tO\ncaused\tO\nby\tO\nNTG\tB-Chemical\nbut\tO\ndid\tO\nnot\tO\nimprove\tO\nlatency\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nhypotension\tB-Disease\n.\tO\n\nThe\tO\nobserved\tO\neffect\tO\nof\tO\nNIMO\tB-Chemical\nmay\tO\nhave\tO\nbeen\tO\nattributable\tO\nto\tO\nthe\tO\npreservation\tO\nof\tO\ncalcium\tB-Chemical\nhomeostasis\tO\nduring\tO\nhypotension\tB-Disease\n,\tO\nbecause\tO\nthere\tO\nwere\tO\nno\tO\ndifferences\tO\nin\tO\nthe\tO\nPbtO\tO\n(\tO\n2\tO\n)\tO\nindices\tO\namong\tO\ngroups\tO\n.\tO\n\nMetabotropic\tO\nglutamate\tB-Chemical\n7\tO\nreceptor\tO\nsubtype\tO\nmodulates\tO\nmotor\tO\nsymptoms\tO\nin\tO\nrodent\tO\nmodels\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nMetabotropic\tO\nglutamate\tB-Chemical\n(\tO\nmGlu\tO\n)\tO\nreceptors\tO\nmodulate\tO\nsynaptic\tO\ntransmission\tO\nin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\nand\tO\nrepresent\tO\npromising\tO\ntherapeutic\tO\ntargets\tO\nfor\tO\nsymptomatic\tO\ntreatment\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\n.\tO\n\nAmong\tO\nthe\tO\neight\tO\nmGlu\tO\nreceptor\tO\nsubtypes\tO\n,\tO\nmGlu7\tO\nreceptor\tO\nis\tO\nprominently\tO\nexpressed\tO\nin\tO\nthe\tO\nbasal\tO\nganglia\tO\n,\tO\nbut\tO\nits\tO\nrole\tO\nin\tO\nrestoring\tO\nmotor\tO\nfunction\tO\nin\tO\nanimal\tO\nmodels\tO\nof\tO\nPD\tB-Disease\nis\tO\nnot\tO\nknown\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nN\tB-Chemical\n,\tI-Chemical\nN\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\ndibenzhydrylethane\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ndiamine\tI-Chemical\ndihydrochloride\tI-Chemical\n(\tO\nAMN082\tB-Chemical\n)\tO\n,\tO\nthe\tO\nfirst\tO\nselective\tO\nallosteric\tO\nactivator\tO\nof\tO\nmGlu7\tO\nreceptors\tO\n,\tO\nwere\tO\nthus\tO\ntested\tO\nin\tO\ndifferent\tO\nrodent\tO\nmodels\tO\nof\tO\nPD\tB-Disease\n.\tO\n\nHere\tO\n,\tO\nwe\tO\nshow\tO\nthat\tO\noral\tO\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nor\tO\nintrastriatal\tO\nadministration\tO\n(\tO\n0\tO\n.\tO\n1\tO\nand\tO\n0\tO\n.\tO\n5\tO\nnmol\tO\n)\tO\nof\tO\nAMN082\tB-Chemical\nreverses\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nAMN082\tB-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\nand\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nreduces\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nrotations\tO\nin\tO\nunilateral\tO\n6\tB-Chemical\n-\tI-Chemical\nhydroxydopamine\tI-Chemical\n(\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\n)\tO\n-\tO\nlesioned\tO\nrats\tO\n.\tO\n\nIn\tO\na\tO\nmore\tO\ncomplex\tO\ntask\tO\ncommonly\tO\nused\tO\nto\tO\nevaluate\tO\nmajor\tO\nakinetic\tB-Disease\nsymptoms\tO\nof\tO\nPD\tB-Disease\npatients\tO\n,\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nAMN082\tB-Chemical\nreverses\tO\nthe\tO\nincreased\tO\nreaction\tO\ntime\tO\nto\tO\nrespond\tO\nto\tO\na\tO\ncue\tO\nof\tO\nbilateral\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\n-\tO\nlesioned\tO\nrats\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nAMN082\tB-Chemical\nreduces\tO\nthe\tO\nduration\tO\nof\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nin\tO\na\tO\nmGlu7\tO\nreceptor\tO\n-\tO\ndependent\tO\nmanner\tO\nin\tO\nwild\tO\n-\tO\ntype\tO\nbut\tO\nnot\tO\nmGlu7\tO\nreceptor\tO\nknockout\tO\nmice\tO\n.\tO\n\nHigher\tO\ndoses\tO\nof\tO\nAMN082\tB-Chemical\n(\tO\n10\tO\nand\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\nhave\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nsame\tO\nmodels\tO\nof\tO\nPD\tB-Disease\n.\tO\n\nOverall\tO\nthese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nmGlu7\tO\nreceptor\tO\nactivation\tO\ncan\tO\nreverse\tO\nmotor\tO\ndysfunction\tO\nassociated\tO\nwith\tO\nreduced\tO\ndopamine\tB-Chemical\nactivity\tO\n.\tO\n\nSelective\tO\nligands\tO\nof\tO\nmGlu7\tO\nreceptor\tO\nsubtypes\tO\nmay\tO\nthus\tO\nbe\tO\nconsidered\tO\nas\tO\npromising\tO\ncompounds\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nantiparkinsonian\tO\ntherapeutic\tO\nstrategies\tO\n.\tO\n\nSorafenib\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\ndue\tO\nto\tO\ncoronary\tB-Disease\nartery\tI-Disease\nspasm\tI-Disease\n.\tO\n\nA\tO\n65\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nadvanced\tO\nrenal\tB-Disease\ncell\tI-Disease\ncarcinoma\tI-Disease\nwas\tO\nadmitted\tO\ndue\tO\nto\tO\ncontinuing\tO\nchest\tB-Disease\npain\tI-Disease\nat\tO\nrest\tO\n.\tO\n\nTwo\tO\nweeks\tO\nbefore\tO\nhis\tO\nadmission\tO\n,\tO\nsorafenib\tB-Chemical\nhad\tO\nbeen\tO\nstarted\tO\n.\tO\n\nHe\tO\nwas\tO\ndiagnosed\tO\nwith\tO\nnon\tO\n-\tO\nST\tO\n-\tO\nelevation\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nby\tO\nlaboratory\tO\ndata\tO\nand\tO\nelectrocardiogram\tO\n.\tO\n\nEnhanced\tO\nheart\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nalso\tO\nshowed\tO\nsubendocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nwas\tO\nno\tO\nstenosis\tO\nin\tO\ncoronary\tO\narteries\tO\non\tO\nangiography\tO\n.\tO\n\nCoronary\tB-Disease\nartery\tI-Disease\nspasm\tI-Disease\nwas\tO\ninduced\tO\nby\tO\na\tO\nprovocative\tO\ntest\tO\n.\tO\n\nCessation\tO\nof\tO\nsorafenib\tB-Chemical\nand\tO\nadministration\tO\nof\tO\nCa\tB-Chemical\n-\tO\nchannel\tO\nblocker\tO\nand\tO\nnitrates\tB-Chemical\nameliorated\tO\nhis\tO\nsymptoms\tO\n,\tO\nbut\tO\nrelapse\tO\noccurred\tO\nafter\tO\nresumption\tO\nof\tO\nsorafenib\tB-Chemical\n.\tO\n\nAddition\tO\nof\tO\noral\tO\nnicorandil\tB-Chemical\nreduced\tO\nhis\tO\nsymptoms\tO\nand\tO\nmaintained\tO\nstable\tB-Disease\nangina\tI-Disease\nstatus\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\nfirst\tO\ncase\tO\nof\tO\nsorafenib\tB-Chemical\n-\tO\ninduced\tO\ncoronary\tB-Disease\nartery\tI-Disease\nspasm\tI-Disease\n.\tO\n\nSorafenib\tB-Chemical\nis\tO\na\tO\nmultikinase\tO\ninhibitor\tO\nthat\tO\ntargets\tO\nsignaling\tO\npathways\tO\nnecessary\tO\nfor\tO\ncellular\tO\nproliferation\tO\nand\tO\nsurvival\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nthe\tO\nRho\tO\n/\tO\nROCK\tO\npathway\tO\nhas\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\ncoronary\tB-Disease\nartery\tI-Disease\nspasm\tI-Disease\n.\tO\n\nOur\tO\nreport\tO\nmay\tO\nshow\tO\nan\tO\nadverse\tO\neffect\tO\non\tO\nthe\tO\nRho\tO\n/\tO\nROCK\tO\npathway\tO\nby\tO\nsorafenib\tB-Chemical\nuse\tO\n.\tO\n\nA\tO\nnovel\tO\nanimal\tO\nmodel\tO\nto\tO\nevaluate\tO\nthe\tO\nability\tO\nof\tO\na\tO\ndrug\tO\ndelivery\tO\nsystem\tO\nto\tO\npromote\tO\nthe\tO\npassage\tO\nthrough\tO\nthe\tO\nBBB\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\ninvestigation\tO\nwas\tO\nto\tO\nexplore\tO\nthe\tO\npotentiality\tO\nof\tO\na\tO\nnovel\tO\nanimal\tO\nmodel\tO\nto\tO\nbe\tO\nused\tO\nfor\tO\nthe\tO\nin\tO\nvivo\tO\nevaluation\tO\nof\tO\nthe\tO\nability\tO\nof\tO\na\tO\ndrug\tO\ndelivery\tO\nsystem\tO\nto\tO\npromote\tO\nthe\tO\npassage\tO\nthrough\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n(\tO\nBBB\tO\n)\tO\nand\tO\n/\tO\nor\tO\nto\tO\nimprove\tO\nthe\tO\nbrain\tO\nlocalization\tO\nof\tO\na\tO\nbioactive\tO\ncompound\tO\n.\tO\n\nA\tO\nTween\tO\n80\tO\n-\tO\ncoated\tO\npoly\tB-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\nlactid\tI-Chemical\nacid\tI-Chemical\nnanoparticles\tO\nwas\tO\nused\tO\nas\tO\na\tO\nmodel\tO\nof\tO\ncolloidal\tO\ndrug\tO\ndelivery\tO\nsystem\tO\n,\tO\nable\tO\nto\tO\ntrespass\tO\nthe\tO\nBBB\tO\n.\tO\n\nTacrine\tB-Chemical\n,\tO\nadministered\tO\nin\tO\nLiCl\tB-Chemical\npre\tO\n-\tO\ntreated\tO\nrats\tO\n,\tO\ninduces\tO\nelectrocorticographic\tO\nseizures\tB-Disease\nand\tO\ndelayed\tO\nhippocampal\tB-Disease\ndamage\tI-Disease\n.\tO\n\nThe\tO\ntoxic\tO\neffects\tO\nof\tO\ntacrine\tB-Chemical\n-\tO\nloaded\tO\npoly\tB-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\nlactid\tI-Chemical\nacid\tI-Chemical\nnanoparticles\tO\n(\tO\n5mg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\na\tO\nsaline\tO\nsolution\tO\nof\tO\ntacrine\tB-Chemical\n(\tO\n5mg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\nan\tO\nempty\tO\ncolloidal\tO\nnanoparticle\tO\nsuspension\tO\nwere\tO\ncompared\tO\nfollowing\tO\ni\tO\n.\tO\np\tO\n.\tO\nadministration\tO\nin\tO\nLiCl\tB-Chemical\n-\tO\npre\tO\n-\tO\ntreated\tO\nWistar\tO\nrats\tO\n.\tO\n\nAll\tO\nthe\tO\nanimals\tO\ntreated\tO\nwith\tO\ntacrine\tB-Chemical\n-\tO\nloaded\tO\nnanoparticles\tO\nshowed\tO\nan\tO\nearlier\tO\noutcome\tO\nof\tO\nCNS\tO\nadverse\tO\nsymptoms\tO\n,\tO\ni\tO\n.\tO\ne\tO\n.\tO\nepileptic\tB-Disease\nonset\tO\n,\tO\nwith\tO\nrespect\tO\nto\tO\nthose\tO\nanimals\tO\ntreated\tO\nwith\tO\nthe\tO\nfree\tO\ncompound\tO\n(\tO\n10\tO\nmin\tO\nvs\tO\n.\tO\n22\tO\nmin\tO\nrespectively\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\ntacrine\tB-Chemical\n-\tO\nloaded\tO\nnanoparticles\tO\nadministration\tO\ninduced\tO\ndamage\tB-Disease\nof\tI-Disease\nneuronal\tI-Disease\ncells\tI-Disease\nin\tO\nCA1\tO\nfield\tO\nof\tO\nthe\tO\nhippocampus\tO\nin\tO\nall\tO\ntreated\tO\nanimals\tO\n,\tO\nwhile\tO\nthe\tO\nsaline\tO\nsolution\tO\nof\tO\ntacrine\tB-Chemical\nonly\tO\nin\tO\n60\tO\n%\tO\nof\tO\nanimals\tO\n.\tO\n\nEmpty\tO\nnanoparticles\tO\nprovided\tO\nsimilar\tO\nresults\tO\nto\tO\ncontrol\tO\n(\tO\nsaline\tO\n-\tO\ntreated\tO\n)\tO\ngroup\tO\nof\tO\nanimals\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\nevaluation\tO\nof\tO\ntime\tO\n-\tO\nto\tO\n-\tO\nonset\tO\nof\tO\nsymptoms\tO\nand\tO\nthe\tO\nseverity\tO\nof\tO\nneurodegenerative\tO\nprocesses\tO\ninduced\tO\nby\tO\nthe\tO\ntacrine\tB-Chemical\n-\tO\nlithium\tB-Chemical\nmodel\tO\nof\tO\nepilepsy\tB-Disease\nin\tO\nthe\tO\nrat\tO\n,\tO\ncould\tO\nbe\tO\nused\tO\nto\tO\nevaluate\tO\npreliminarily\tO\nthe\tO\ncapability\tO\nof\tO\na\tO\ndrug\tO\ndelivery\tO\nsystem\tO\nto\tO\ntrespass\tO\n(\tO\nor\tO\nnot\tO\n)\tO\nthe\tO\nBBB\tO\nin\tO\nvivo\tO\n.\tO\n\nHigh\tO\n-\tO\ndose\tO\ntranexamic\tB-Chemical\nAcid\tI-Chemical\nis\tO\nassociated\tO\nwith\tO\nnonischemic\tO\nclinical\tO\nseizures\tB-Disease\nin\tO\ncardiac\tO\nsurgical\tO\npatients\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIn\tO\n2\tO\nseparate\tO\ncenters\tO\n,\tO\nwe\tO\nobserved\tO\na\tO\nnotable\tO\nincrease\tO\nin\tO\nthe\tO\nincidence\tO\nof\tO\npostoperative\tO\nconvulsive\tB-Disease\nseizures\tB-Disease\nfrom\tO\n1\tO\n.\tO\n3\tO\n%\tO\nto\tO\n3\tO\n.\tO\n8\tO\n%\tO\nin\tO\npatients\tO\nhaving\tO\nundergone\tO\nmajor\tO\ncardiac\tO\nsurgical\tO\nprocedures\tO\n.\tO\n\nThese\tO\nevents\tO\nwere\tO\ntemporally\tO\ncoincident\tO\nwith\tO\nthe\tO\ninitial\tO\nuse\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\n(\tO\nTXA\tB-Chemical\n)\tO\ntherapy\tO\nafter\tO\nwithdrawal\tO\nof\tO\naprotinin\tO\nfrom\tO\ngeneral\tO\nclinical\tO\nusage\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nreview\tO\nwas\tO\nto\tO\nperform\tO\na\tO\nretrospective\tO\nanalysis\tO\nto\tO\nexamine\tO\nwhether\tO\nthere\tO\nwas\tO\na\tO\nrelation\tO\nbetween\tO\nTXA\tB-Chemical\nusage\tO\nand\tO\nseizures\tB-Disease\nafter\tO\ncardiac\tO\nsurgery\tO\n.\tO\n\nMETHODS\tO\n:\tO\nAn\tO\nin\tO\n-\tO\ndepth\tO\nchart\tO\nreview\tO\nwas\tO\nundertaken\tO\nin\tO\nall\tO\n24\tO\npatients\tO\nwho\tO\ndeveloped\tO\nperioperative\tO\nseizures\tB-Disease\n.\tO\n\nElectroencephalographic\tO\nactivity\tO\nwas\tO\nrecorded\tO\nin\tO\n11\tO\nof\tO\nthese\tO\npatients\tO\n,\tO\nand\tO\nall\tO\npatients\tO\nhad\tO\na\tO\nformal\tO\nneurological\tO\nevaluation\tO\nand\tO\nbrain\tO\nimaging\tO\nstudies\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTwenty\tO\n-\tO\none\tO\nof\tO\nthe\tO\n24\tO\npatients\tO\ndid\tO\nnot\tO\nhave\tO\nevidence\tO\nof\tO\nnew\tO\ncerebral\tB-Disease\nischemic\tI-Disease\ninjury\tI-Disease\n,\tO\nbut\tO\nseizures\tB-Disease\nwere\tO\nlikely\tO\ndue\tO\nto\tO\nischemic\tB-Disease\nbrain\tI-Disease\ninjury\tI-Disease\nin\tO\n3\tO\npatients\tO\n.\tO\n\nAll\tO\npatients\tO\nwith\tO\nseizures\tB-Disease\ndid\tO\nnot\tO\nhave\tO\npermanent\tO\nneurological\tB-Disease\nabnormalities\tI-Disease\n.\tO\n\nAll\tO\n24\tO\npatients\tO\nwith\tO\nseizures\tB-Disease\nreceived\tO\nhigh\tO\ndoses\tO\nof\tO\nTXA\tB-Chemical\nintraoperatively\tO\nranging\tO\nfrom\tO\n61\tO\nto\tO\n259\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nhad\tO\na\tO\nmean\tO\nage\tO\nof\tO\n69\tO\n.\tO\n9\tO\nyears\tO\n,\tO\nand\tO\n21\tO\nof\tO\n24\tO\nhad\tO\nundergone\tO\nopen\tO\nchamber\tO\nrather\tO\nthan\tO\ncoronary\tO\nbypass\tO\nprocedures\tO\n.\tO\n\nAll\tO\nbut\tO\none\tO\npatient\tO\nwere\tO\nmanaged\tO\nusing\tO\ncardiopulmonary\tO\nbypass\tO\n.\tO\n\nNo\tO\nevidence\tO\nof\tO\nbrain\tB-Disease\nischemic\tI-Disease\n,\tO\nmetabolic\tO\n,\tO\nor\tO\nhyperthermia\tB-Disease\n-\tO\ninduced\tO\ncauses\tO\nfor\tO\ntheir\tO\nseizures\tB-Disease\nwas\tO\napparent\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\nresults\tO\nsuggest\tO\nthat\tO\nuse\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\nTXA\tB-Chemical\nin\tO\nolder\tO\npatients\tO\nin\tO\nconjunction\tO\nwith\tO\ncardiopulmonary\tO\nbypass\tO\nand\tO\nopen\tO\n-\tO\nchamber\tO\ncardiac\tO\nsurgery\tO\nis\tO\nassociated\tO\nwith\tO\nclinical\tO\nseizures\tB-Disease\nin\tO\nsusceptible\tO\npatients\tO\n.\tO\n\nElectrocardiographic\tO\nchanges\tO\nand\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\nin\tO\npatients\tO\nreceiving\tO\npsychotropic\tO\ndrugs\tO\n.\tO\n\nEight\tO\npatients\tO\nhad\tO\ncardiac\tO\nmanifestations\tO\nthat\tO\nwere\tO\nlife\tO\n-\tO\nthreatening\tO\nin\tO\nfive\tO\nwhile\tO\ntaking\tO\npsychotropic\tO\ndrugs\tO\n,\tO\neither\tO\nphenothiazines\tB-Chemical\nor\tO\ntricyclic\tO\nantidepressants\tO\n.\tO\n\nAlthough\tO\nmost\tO\npatients\tO\nwere\tO\nreceiving\tO\nseveral\tO\ndrugs\tO\n,\tO\nMellaril\tB-Chemical\n(\tO\nthioridazine\tB-Chemical\n)\tO\nappeared\tO\nto\tO\nbe\tO\nresponsible\tO\nfor\tO\nfive\tO\ncases\tO\nof\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n,\tO\none\tO\nof\tO\nwhich\tO\nwas\tO\nfatal\tO\nin\tO\na\tO\n35\tO\nyear\tO\nold\tO\nwoman\tO\n.\tO\n\nSupraventricular\tB-Disease\ntachycardia\tI-Disease\ndeveloped\tO\nin\tO\none\tO\npatient\tO\nreceiving\tO\nThorazine\tB-Chemical\n(\tO\nchlorpromazine\tB-Chemical\n)\tO\n.\tO\n\nAventyl\tB-Chemical\n(\tO\nnortriptyline\tB-Chemical\n)\tO\nand\tO\nElavil\tB-Chemical\n(\tO\namitriptyline\tB-Chemical\n)\tO\neach\tO\nproduced\tO\nleft\tB-Disease\nbundle\tI-Disease\nbranch\tI-Disease\nblock\tI-Disease\nin\tO\na\tO\n73\tO\nyear\tO\nold\tO\nwoman\tO\n.\tO\n\nElectrocardiographic\tO\nT\tO\nand\tO\nU\tO\nwave\tO\nabnormalities\tO\nwere\tO\npresent\tO\nin\tO\nmost\tO\npatients\tO\n.\tO\n\nThe\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\nresponded\tO\nto\tO\nintravenous\tO\nadministration\tO\nof\tO\nlidocaine\tB-Chemical\nand\tO\nto\tO\ndirect\tO\ncurrent\tO\nelectric\tO\nshock\tO\n;\tO\nventricular\tO\npacing\tO\nwas\tO\nrequired\tO\nin\tO\nsome\tO\ninstances\tO\nand\tO\nintravenous\tO\nadministration\tO\nof\tO\npropranolol\tB-Chemical\ncombined\tO\nwith\tO\nventricular\tO\npacing\tO\nin\tO\none\tO\n.\tO\n\nThe\tO\ntachyarrhythmias\tB-Disease\ngenerally\tO\nsubsided\tO\nwithin\tO\n48\tO\nhours\tO\nafter\tO\nadministration\tO\nof\tO\nthe\tO\ndrugs\tO\nwas\tO\nstopped\tO\n.\tO\n\nFive\tO\nof\tO\nthe\tO\neight\tO\npatients\tO\nwere\tO\n50\tO\nyears\tO\nof\tO\nage\tO\nor\tO\nyounger\tO\n;\tO\nonly\tO\none\tO\nclearly\tO\nhad\tO\nantecedent\tO\nheart\tB-Disease\ndisease\tI-Disease\n.\tO\n\nMajor\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\nare\tO\na\tO\npotential\tO\nhazard\tO\nin\tO\npatients\tO\nwithout\tO\nheart\tB-Disease\ndisease\tI-Disease\nwho\tO\nare\tO\nreceiving\tO\ncustomary\tO\ntherapeutic\tO\ndoses\tO\nof\tO\npsychotropic\tO\ndrugs\tO\n.\tO\n\nA\tO\nprospective\tO\nclinical\tO\ntrial\tO\nis\tO\nsuggested\tO\nto\tO\nquantify\tO\nthe\tO\nrisk\tO\nof\tO\ncardiac\tB-Disease\ncomplications\tI-Disease\nto\tO\npatients\tO\nreceiving\tO\nphenothiazines\tB-Chemical\nor\tO\ntricyclic\tO\nantidepressant\tO\ndrugs\tO\n.\tO\n\nSensitivity\tO\nof\tO\nerythroid\tO\nprogenitor\tO\ncolonies\tO\nto\tO\nerythropoietin\tO\nin\tO\nazidothymidine\tB-Chemical\ntreated\tO\nimmunodeficient\tB-Disease\nmice\tO\n.\tO\n\nThe\tO\nanaemia\tB-Disease\ninduced\tO\nby\tO\n3\tB-Chemical\n'\tI-Chemical\n-\tI-Chemical\nazido\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n'\tI-Chemical\ndideoxythymidine\tI-Chemical\n(\tO\nAZT\tB-Chemical\n)\tO\nis\tO\npoorly\tO\nunderstood\tO\n.\tO\n\nWe\tO\nhave\tO\nused\tO\na\tO\nmurine\tO\nmodel\tO\nof\tO\nAIDS\tB-Disease\n,\tO\ninfection\tB-Disease\nof\tO\nfemale\tO\nC57BL\tO\n/\tO\n6\tO\nmice\tO\nwith\tO\nLP\tO\n-\tO\nBM5\tO\nmurine\tO\nleukaemia\tB-Disease\n(\tO\nMuLV\tO\n)\tO\nvirus\tO\n,\tO\nto\tO\ndetermine\tO\nif\tO\nAZT\tB-Chemical\n-\tO\ninduced\tO\nanaemia\tB-Disease\nis\tO\ndue\tO\n,\tO\nin\tO\npart\tO\n,\tO\nto\tO\ndecreased\tO\nresponsiveness\tO\nof\tO\nerythropoietic\tO\nprecursors\tO\n(\tO\nBFU\tO\n-\tO\ne\tO\n)\tO\nto\tO\nerythropoietin\tO\n(\tO\nEPO\tO\n)\tO\n.\tO\n\nMice\tO\nin\tO\nthe\tO\nearly\tO\nstage\tO\nof\tO\nLP\tO\n-\tO\nBM5\tO\nMuLV\tO\ndisease\tO\nwere\tO\ngiven\tO\nAZT\tB-Chemical\nin\tO\ntheir\tO\ndrinking\tO\nwater\tO\nat\tO\n1\tO\n.\tO\n0\tO\nand\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\n.\tO\n\nAZT\tB-Chemical\nproduced\tO\nanaemia\tB-Disease\nin\tO\nboth\tO\ngroups\tO\n,\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nfashion\tO\n.\tO\n\nDespite\tO\nthe\tO\nanaemia\tB-Disease\n,\tO\nthe\tO\nnumber\tO\nof\tO\nsplenic\tO\nand\tO\nbone\tO\nmarrow\tO\nBFU\tO\n-\tO\ne\tO\nin\tO\nAZT\tB-Chemical\ntreated\tO\nmice\tO\nincreased\tO\nup\tO\nto\tO\nfive\tO\n-\tO\nfold\tO\nover\tO\nlevels\tO\nobserved\tO\nin\tO\ninfected\tO\nuntreated\tO\nanimals\tO\nafter\tO\n15\tO\nd\tO\nof\tO\ntreatment\tO\n.\tO\n\nColony\tO\nformation\tO\nby\tO\nsplenic\tO\nand\tO\nbone\tO\nmarrow\tO\nBFUe\tO\nwas\tO\nstimulated\tO\nat\tO\nlower\tO\nconcentrations\tO\nof\tO\nEPO\tO\nin\tO\nmice\tO\nreceiving\tO\nAZT\tB-Chemical\nfor\tO\n15\tO\nd\tO\nthan\tO\nfor\tO\ninfected\tO\n,\tO\nuntreated\tO\nmice\tO\n.\tO\n\nBy\tO\nday\tO\n30\tO\n,\tO\nsensitivity\tO\nof\tO\nboth\tO\nsplenic\tO\nand\tO\nbone\tO\nmarrow\tO\nBFU\tO\n-\tO\ne\tO\nof\tO\ntreated\tO\nanimals\tO\nreturned\tO\nto\tO\nthat\tO\nobserved\tO\nfrom\tO\ncells\tO\nof\tO\ninfected\tO\nuntreated\tO\nanimals\tO\n.\tO\n\nThe\tO\nmean\tO\nplasma\tO\nlevels\tO\nof\tO\nEPO\tO\nobserved\tO\nin\tO\nAZT\tB-Chemical\ntreated\tO\nmice\tO\nwere\tO\nappropriate\tO\nfor\tO\nthe\tO\ndegree\tO\nof\tO\nanaemia\tB-Disease\nobserved\tO\nwhen\tO\ncompared\tO\nwith\tO\nphenylhydrazine\tB-Chemical\n(\tO\nPHZ\tB-Chemical\n)\tO\ntreated\tO\nmice\tO\n.\tO\n\nThe\tO\nnumbers\tO\nof\tO\nBFU\tO\n-\tO\ne\tO\nand\tO\nthe\tO\npercentage\tO\nof\tO\nbone\tO\nmarrow\tO\nerythroblasts\tO\nobserved\tO\nwere\tO\ncomparable\tO\nin\tO\nAZT\tB-Chemical\nand\tO\nPHZ\tB-Chemical\ntreated\tO\nmice\tO\nwith\tO\nsimilar\tO\ndegrees\tO\nof\tO\nanaemia\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nreticulocytosis\tB-Disease\nwas\tO\ninappropriate\tO\nfor\tO\nthe\tO\ndegree\tO\nof\tO\nanaemia\tB-Disease\nobserved\tO\nin\tO\nAZT\tB-Chemical\ntreated\tO\ninfected\tO\nmice\tO\n.\tO\n\nAZT\tB-Chemical\n-\tO\ninduced\tO\nperipheral\tO\nanaemia\tB-Disease\nin\tO\nthe\tO\nface\tO\nof\tO\nincreased\tO\nnumbers\tO\nof\tO\nBFU\tO\n-\tO\ne\tO\nand\tO\nincreased\tO\nlevels\tO\nof\tO\nplasma\tO\nEPO\tO\nsuggest\tO\na\tO\nlesion\tO\nin\tO\nterminal\tO\ndifferentiation\tO\n.\tO\n\nSedation\tO\ndepth\tO\nduring\tO\nspinal\tO\nanesthesia\tO\nand\tO\nthe\tO\ndevelopment\tO\nof\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\nin\tO\nelderly\tO\npatients\tO\nundergoing\tO\nhip\tB-Disease\nfracture\tI-Disease\nrepair\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndetermine\tO\nwhether\tO\nlimiting\tO\nintraoperative\tO\nsedation\tO\ndepth\tO\nduring\tO\nspinal\tO\nanesthesia\tO\nfor\tO\nhip\tB-Disease\nfracture\tI-Disease\nrepair\tO\nin\tO\nelderly\tO\npatients\tO\ncan\tO\ndecrease\tO\nthe\tO\nprevalence\tO\nof\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nWe\tO\nperformed\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nrandomized\tO\ncontrolled\tO\ntrial\tO\nat\tO\nan\tO\nacademic\tO\nmedical\tO\ncenter\tO\nof\tO\nelderly\tO\npatients\tO\n(\tO\n>\tO\nor\tO\n=\tO\n65\tO\nyears\tO\n)\tO\nwithout\tO\npreoperative\tO\ndelirium\tB-Disease\nor\tO\nsevere\tO\ndementia\tB-Disease\nwho\tO\nunderwent\tO\nhip\tB-Disease\nfracture\tI-Disease\nrepair\tO\nunder\tO\nspinal\tO\nanesthesia\tO\nwith\tO\npropofol\tB-Chemical\nsedation\tO\n.\tO\n\nSedation\tO\ndepth\tO\nwas\tO\ntitrated\tO\nusing\tO\nprocessed\tO\nelectroencephalography\tO\nwith\tO\nthe\tO\nbispectral\tO\nindex\tO\n(\tO\nBIS\tO\n)\tO\n,\tO\nand\tO\npatients\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\neither\tO\ndeep\tO\n(\tO\nBIS\tO\n,\tO\napproximately\tO\n50\tO\n)\tO\nor\tO\nlight\tO\n(\tO\nBIS\tO\n,\tO\n>\tO\nor\tO\n=\tO\n80\tO\n)\tO\nsedation\tO\n.\tO\n\nPostoperative\tB-Disease\ndelirium\tI-Disease\nwas\tO\nassessed\tO\nas\tO\ndefined\tO\nby\tO\nDiagnostic\tO\nand\tO\nStatistical\tO\nManual\tO\nof\tO\nMental\tB-Disease\nDisorders\tI-Disease\n(\tO\nThird\tO\nEdition\tO\nRevised\tO\n)\tO\ncriteria\tO\nusing\tO\nthe\tO\nConfusion\tO\nAssessment\tO\nMethod\tO\nbeginning\tO\nat\tO\nany\tO\ntime\tO\nfrom\tO\nthe\tO\nsecond\tO\nday\tO\nafter\tO\nsurgery\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFrom\tO\nApril\tO\n2\tO\n,\tO\n2005\tO\n,\tO\nthrough\tO\nOctober\tO\n30\tO\n,\tO\n2008\tO\n,\tO\na\tO\ntotal\tO\nof\tO\n114\tO\npatients\tO\nwere\tO\nrandomized\tO\n.\tO\n\nThe\tO\nprevalence\tO\nof\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\nwas\tO\nsignificantly\tO\nlower\tO\nin\tO\nthe\tO\nlight\tO\nsedation\tO\ngroup\tO\n(\tO\n11\tO\n/\tO\n57\tO\n[\tO\n19\tO\n%\tO\n]\tO\nvs\tO\n23\tO\n/\tO\n57\tO\n[\tO\n40\tO\n%\tO\n]\tO\nin\tO\nthe\tO\ndeep\tO\nsedation\tO\ngroup\tO\n;\tO\nP\tO\n=\tO\n.\tO\n02\tO\n)\tO\n,\tO\nindicating\tO\nthat\tO\n1\tO\nincident\tO\nof\tO\ndelirium\tB-Disease\nwill\tO\nbe\tO\nprevented\tO\nfor\tO\nevery\tO\n4\tO\n.\tO\n7\tO\npatients\tO\ntreated\tO\nwith\tO\nlight\tO\nsedation\tO\n.\tO\n\nThe\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\nnumber\tO\nof\tO\ndays\tO\nof\tO\ndelirium\tB-Disease\nduring\tO\nhospitalization\tO\nwas\tO\nlower\tO\nin\tO\nthe\tO\nlight\tO\nsedation\tO\ngroup\tO\nthan\tO\nin\tO\nthe\tO\ndeep\tO\nsedation\tO\ngroup\tO\n(\tO\n0\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n5\tO\ndays\tO\nvs\tO\n1\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n0\tO\ndays\tO\n;\tO\nP\tO\n=\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nuse\tO\nof\tO\nlight\tO\npropofol\tB-Chemical\nsedation\tO\ndecreased\tO\nthe\tO\nprevalence\tO\nof\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\nby\tO\n50\tO\n%\tO\ncompared\tO\nwith\tO\ndeep\tO\nsedation\tO\n.\tO\n\nLimiting\tO\ndepth\tO\nof\tO\nsedation\tO\nduring\tO\nspinal\tO\nanesthesia\tO\nis\tO\na\tO\nsimple\tO\n,\tO\nsafe\tO\n,\tO\nand\tO\ncost\tO\n-\tO\neffective\tO\nintervention\tO\nfor\tO\npreventing\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\nin\tO\nelderly\tO\npatients\tO\nthat\tO\ncould\tO\nbe\tO\nwidely\tO\nand\tO\nreadily\tO\nadopted\tO\n.\tO\n\nThe\tO\nprotective\tO\nrole\tO\nof\tO\nNrf2\tO\nin\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nDiabetic\tB-Disease\nnephropathy\tI-Disease\nis\tO\none\tO\nof\tO\nthe\tO\nmajor\tO\ncauses\tO\nof\tO\nrenal\tB-Disease\nfailure\tI-Disease\n,\tO\nwhich\tO\nis\tO\naccompanied\tO\nby\tO\nthe\tO\nproduction\tO\nof\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\n(\tO\nROS\tO\n)\tO\n.\tO\n\nNrf2\tO\nis\tO\nthe\tO\nprimary\tO\ntranscription\tO\nfactor\tO\nthat\tO\ncontrols\tO\nthe\tO\nantioxidant\tO\nresponse\tO\nessential\tO\nfor\tO\nmaintaining\tO\ncellular\tO\nredox\tO\nhomeostasis\tO\n.\tO\n\nHere\tO\n,\tO\nwe\tO\nreport\tO\nour\tO\nfindings\tO\ndemonstrating\tO\na\tO\nprotective\tO\nrole\tO\nof\tO\nNrf2\tO\nagainst\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n.\tO\n\nRESEARCH\tO\nDESIGN\tO\nAND\tO\nMETHODS\tO\n:\tO\nWe\tO\nexplore\tO\nthe\tO\nprotective\tO\nrole\tO\nof\tO\nNrf2\tO\nagainst\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\nusing\tO\nhuman\tO\nkidney\tO\nbiopsy\tO\ntissues\tO\nfrom\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\npatients\tO\n,\tO\na\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\nmodel\tO\nin\tO\nNrf2\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n,\tO\nand\tO\ncultured\tO\nhuman\tO\nmesangial\tO\ncells\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nglomeruli\tO\nof\tO\nhuman\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\npatients\tO\nwere\tO\nunder\tO\noxidative\tO\nstress\tO\nand\tO\nhad\tO\nelevated\tO\nNrf2\tO\nlevels\tO\n.\tO\n\nIn\tO\nthe\tO\nanimal\tO\nstudy\tO\n,\tO\nNrf2\tO\nwas\tO\ndemonstrated\tO\nto\tO\nbe\tO\ncrucial\tO\nin\tO\nameliorating\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ndamage\tI-Disease\n.\tO\n\nThis\tO\nis\tO\nevident\tO\nby\tO\nNrf2\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nhaving\tO\nhigher\tO\nROS\tO\nproduction\tO\nand\tO\nsuffering\tO\nfrom\tO\ngreater\tO\noxidative\tO\nDNA\tO\ndamage\tO\nand\tO\nrenal\tB-Disease\ninjury\tI-Disease\ncompared\tO\nwith\tO\nNrf2\tO\n(\tO\n+\tO\n/\tO\n+\tO\n)\tO\nmice\tO\n.\tO\n\nMechanistic\tO\nstudies\tO\nin\tO\nboth\tO\nin\tO\nvivo\tO\nand\tO\nin\tO\nvitro\tO\nsystems\tO\nshowed\tO\nthat\tO\nthe\tO\nNrf2\tO\n-\tO\nmediated\tO\nprotection\tO\nagainst\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\nis\tO\n,\tO\nat\tO\nleast\tO\n,\tO\npartially\tO\nthrough\tO\ninhibition\tO\nof\tO\ntransforming\tO\ngrowth\tO\nfactor\tO\n-\tO\nbeta1\tO\n(\tO\nTGF\tO\n-\tO\nbeta1\tO\n)\tO\nand\tO\nreduction\tO\nof\tO\nextracellular\tO\nmatrix\tO\nproduction\tO\n.\tO\n\nIn\tO\nhuman\tO\nrenal\tO\nmesangial\tO\ncells\tO\n,\tO\nhigh\tO\nglucose\tB-Chemical\ninduced\tO\nROS\tO\nproduction\tO\nand\tO\nactivated\tO\nexpression\tO\nof\tO\nNrf2\tO\nand\tO\nits\tO\ndownstream\tO\ngenes\tO\n.\tO\n\nFurthermore\tO\n,\tO\nactivation\tO\nor\tO\noverexpression\tO\nof\tO\nNrf2\tO\ninhibited\tO\nthe\tO\npromoter\tO\nactivity\tO\nof\tO\nTGF\tO\n-\tO\nbeta1\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n,\tO\nwhereas\tO\nknockdown\tO\nof\tO\nNrf2\tO\nby\tO\nsiRNA\tO\nenhanced\tO\nTGF\tO\n-\tO\nbeta1\tO\ntranscription\tO\nand\tO\nfibronectin\tO\nproduction\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThis\tO\nwork\tO\nclearly\tO\nindicates\tO\na\tO\nprotective\tO\nrole\tO\nof\tO\nNrf2\tO\nin\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n,\tO\nsuggesting\tO\nthat\tO\ndietary\tO\nor\tO\ntherapeutic\tO\nactivation\tO\nof\tO\nNrf2\tO\ncould\tO\nbe\tO\nused\tO\nas\tO\na\tO\nstrategy\tO\nto\tO\nprevent\tO\nor\tO\nslow\tO\ndown\tO\nthe\tO\nprogression\tO\nof\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n.\tO\n\nMetformin\tB-Chemical\nprevents\tO\nexperimental\tO\ngentamicin\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\nby\tO\na\tO\nmitochondria\tO\n-\tO\ndependent\tO\npathway\tO\n.\tO\n\nThe\tO\nantidiabetic\tO\ndrug\tO\nmetformin\tB-Chemical\ncan\tO\ndiminish\tO\napoptosis\tO\ninduced\tO\nby\tO\noxidative\tO\nstress\tO\nin\tO\nendothelial\tO\ncells\tO\nand\tO\nprevent\tO\nvascular\tB-Disease\ndysfunction\tI-Disease\neven\tO\nin\tO\nnondiabetic\tO\npatients\tO\n.\tO\n\nHere\tO\nwe\tO\ntested\tO\nwhether\tO\nit\tO\nhas\tO\na\tO\nbeneficial\tO\neffect\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\ngentamicin\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nMitochondrial\tO\nanalysis\tO\n,\tO\nrespiration\tO\nintensity\tO\n,\tO\nlevels\tO\nof\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\n,\tO\npermeability\tO\ntransition\tO\n,\tO\nand\tO\ncytochrome\tO\nc\tO\nrelease\tO\nwere\tO\nassessed\tO\n3\tO\nand\tO\n6\tO\ndays\tO\nafter\tO\ngentamicin\tB-Chemical\nadministration\tO\n.\tO\n\nMetformin\tB-Chemical\ntreatment\tO\nfully\tO\nblocked\tO\ngentamicin\tB-Chemical\n-\tO\nmediated\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nThis\tO\nwas\tO\naccompanied\tO\nby\tO\na\tO\nlower\tO\nactivity\tO\nof\tO\nN\tO\n-\tO\nacetyl\tO\n-\tO\nbeta\tO\n-\tO\nD\tO\n-\tO\nglucosaminidase\tO\n,\tO\ntogether\tO\nwith\tO\na\tO\ndecrease\tO\nof\tO\nlipid\tO\nperoxidation\tO\nand\tO\nincrease\tO\nof\tO\nantioxidant\tO\nsystems\tO\n.\tO\n\nMetformin\tB-Chemical\nalso\tO\nprotected\tO\nthe\tO\nkidney\tO\nfrom\tO\nhistological\tO\ndamage\tO\n6\tO\ndays\tO\nafter\tO\ngentamicin\tB-Chemical\nadministration\tO\n.\tO\n\nThese\tO\nin\tO\nvivo\tO\nmarkers\tO\nof\tO\nkidney\tB-Disease\ndysfunction\tI-Disease\nand\tO\ntheir\tO\ncorrection\tO\nby\tO\nmetformin\tB-Chemical\nwere\tO\ncomplemented\tO\nby\tO\nin\tO\nvitro\tO\nstudies\tO\nof\tO\nmitochondrial\tO\nfunction\tO\n.\tO\n\nWe\tO\nfound\tO\nthat\tO\ngentamicin\tB-Chemical\ntreatment\tO\ndepleted\tO\nrespiratory\tO\ncomponents\tO\n(\tO\ncytochrome\tO\nc\tO\n,\tO\nNADH\tO\n)\tO\n,\tO\nprobably\tO\ndue\tO\nto\tO\nthe\tO\nopening\tO\nof\tO\nmitochondrial\tO\ntransition\tO\npores\tO\n.\tO\n\nThese\tO\ninjuries\tO\n,\tO\npartly\tO\nmediated\tO\nby\tO\na\tO\nrise\tO\nin\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\nfrom\tO\nthe\tO\nelectron\tO\ntransfer\tO\nchain\tO\n,\tO\nwere\tO\nsignificantly\tO\ndecreased\tO\nby\tO\nmetformin\tB-Chemical\n.\tO\n\nThus\tO\n,\tO\nour\tO\nstudy\tO\nsuggests\tO\nthat\tO\npleiotropic\tO\neffects\tO\nof\tO\nmetformin\tB-Chemical\ncan\tO\nlessen\tO\ngentamicin\tB-Chemical\nnephrotoxicity\tB-Disease\nand\tO\nimprove\tO\nmitochondrial\tO\nhomeostasis\tO\n.\tO\n\nRisk\tO\nof\tO\nnephropathy\tB-Disease\nafter\tO\nconsumption\tO\nof\tO\nnonionic\tO\ncontrast\tB-Chemical\nmedia\tI-Chemical\nby\tO\nchildren\tO\nundergoing\tO\ncardiac\tO\nangiography\tO\n:\tO\na\tO\nprospective\tO\nstudy\tO\n.\tO\n\nDespite\tO\nincreasing\tO\nreports\tO\non\tO\nnonionic\tO\ncontrast\tB-Chemical\nmedia\tI-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n(\tO\nCIN\tB-Disease\n)\tO\nin\tO\nhospitalized\tO\nadult\tO\npatients\tO\nduring\tO\ncardiac\tO\nprocedures\tO\n,\tO\nthe\tO\nstudies\tO\nin\tO\npediatrics\tO\nare\tO\nlimited\tO\n,\tO\nwith\tO\neven\tO\nless\tO\nfocus\tO\non\tO\npossible\tO\npredisposing\tO\nfactors\tO\nand\tO\npreventive\tO\nmeasures\tO\nfor\tO\npatients\tO\nundergoing\tO\ncardiac\tO\nangiography\tO\n.\tO\n\nThis\tO\nprospective\tO\nstudy\tO\ndetermined\tO\nthe\tO\nincidence\tO\nof\tO\nCIN\tB-Disease\nfor\tO\ntwo\tO\nnonionic\tO\ncontrast\tB-Chemical\nmedia\tI-Chemical\n(\tO\nCM\tB-Chemical\n)\tO\n,\tO\niopromide\tB-Chemical\nand\tO\niohexol\tB-Chemical\n,\tO\namong\tO\n80\tO\npatients\tO\nyounger\tO\nthan\tO\n18\tO\nyears\tO\nand\tO\ncompared\tO\nthe\tO\nrates\tO\nfor\tO\nthis\tO\ncomplication\tO\nin\tO\nrelation\tO\nto\tO\nthe\tO\ntype\tO\nand\tO\ndosage\tO\nof\tO\nCM\tB-Chemical\nand\tO\nthe\tO\npresence\tO\nof\tO\ncyanosis\tB-Disease\n.\tO\n\nThe\tO\n80\tO\npatients\tO\nin\tO\nthe\tO\nstudy\tO\nconsecutively\tO\nreceived\tO\neither\tO\niopromide\tB-Chemical\n(\tO\ngroup\tO\nA\tO\n,\tO\nn\tO\n=\tO\n40\tO\n)\tO\nor\tO\niohexol\tB-Chemical\n(\tO\ngroup\tO\nB\tO\n,\tO\nn\tO\n=\tO\n40\tO\n)\tO\n.\tO\n\nSerum\tO\nsodium\tB-Chemical\n(\tO\nNa\tB-Chemical\n)\tO\n,\tO\npotassium\tB-Chemical\n(\tO\nK\tB-Chemical\n)\tO\n,\tO\nand\tO\ncreatinine\tB-Chemical\n(\tO\nCr\tB-Chemical\n)\tO\nwere\tO\nmeasured\tO\n24\tO\nh\tO\nbefore\tO\nangiography\tO\nas\tO\nbaseline\tO\nvalues\tO\n,\tO\nthen\tO\nmeasured\tO\nagain\tO\nat\tO\n12\tO\n-\tO\n,\tO\n24\tO\n-\tO\n,\tO\nand\tO\n48\tO\n-\tO\nh\tO\nintervals\tO\nafter\tO\nCM\tB-Chemical\nuse\tO\n.\tO\n\nUrine\tO\nsamples\tO\nfor\tO\nNa\tB-Chemical\nand\tO\nCr\tB-Chemical\nalso\tO\nwere\tO\nchecked\tO\nat\tO\nthe\tO\nsame\tO\nintervals\tO\n.\tO\n\nRisk\tO\nof\tO\nrenal\tB-Disease\nfailure\tI-Disease\n,\tO\nInjury\tB-Disease\nto\tI-Disease\nthe\tI-Disease\nkidney\tI-Disease\n,\tO\nFailure\tB-Disease\nof\tI-Disease\nkidney\tI-Disease\nfunction\tI-Disease\n,\tO\nLoss\tB-Disease\nof\tI-Disease\nkidney\tI-Disease\nfunction\tI-Disease\n,\tO\nand\tO\nEnd\tO\n-\tO\nstage\tO\nrenal\tB-Disease\ndamage\tI-Disease\n(\tO\nRIFLE\tO\ncriteria\tO\n)\tO\nwere\tO\nused\tO\nto\tO\ndefine\tO\nCIN\tB-Disease\nand\tO\nits\tO\nincidence\tO\nin\tO\nthe\tO\nstudy\tO\npopulation\tO\n.\tO\n\nAccordingly\tO\n,\tO\namong\tO\nthe\tO\n15\tO\nCIN\tB-Disease\npatients\tO\n(\tO\n18\tO\n.\tO\n75\tO\n%\tO\n)\tO\n,\tO\n7\tO\n.\tO\n5\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\nin\tO\ngroup\tO\nA\tO\nhad\tO\nincreased\tO\nrisk\tO\nand\tO\n3\tO\n.\tO\n75\tO\n%\tO\nhad\tO\nrenal\tB-Disease\ninjury\tI-Disease\n,\tO\nwhereas\tO\n5\tO\n%\tO\nof\tO\ngroup\tO\nB\tO\nhad\tO\nincreased\tO\nrisk\tO\nand\tO\n2\tO\n.\tO\n5\tO\n%\tO\nhad\tO\nrenal\tB-Disease\ninjury\tI-Disease\n.\tO\n\nWhereas\tO\n33\tO\n.\tO\n3\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\nwith\tO\nCIN\tB-Disease\nwere\tO\namong\tO\nthose\tO\nwho\tO\nreceived\tO\nthe\tO\nproper\tO\ndosage\tO\nof\tO\nCM\tB-Chemical\n,\tO\nthe\tO\npercentage\tO\nincreased\tO\nto\tO\n66\tO\n.\tO\n6\tO\n%\tO\namong\tO\nthose\tO\nwho\tO\nreceived\tO\nlarger\tO\ndoses\tO\n,\tO\nwith\tO\na\tO\nsignificant\tO\ndifference\tO\nin\tO\nthe\tO\nincidence\tO\nof\tO\nCIN\tB-Disease\nrelated\tO\nto\tO\nthe\tO\ndifferent\tO\ndosages\tO\nof\tO\nCM\tB-Chemical\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n014\tO\n)\tO\n.\tO\n\nAmong\tO\nthe\tO\n15\tO\npatients\tO\nwith\tO\nCIN\tB-Disease\n,\tO\n6\tO\nhad\tO\ncyanotic\tO\ncongenital\tB-Disease\nheart\tI-Disease\ndiseases\tI-Disease\n,\tO\nbut\tO\nthe\tO\nincidence\tO\ndid\tO\nnot\tO\ndiffer\tO\nsignificantly\tO\nfrom\tO\nthat\tO\nfor\tO\nthe\tO\nnoncyanotic\tO\npatients\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n243\tO\n)\tO\n.\tO\n\nAlthough\tO\nclinically\tO\nsilent\tO\n,\tO\nCIN\tB-Disease\nis\tO\nnot\tO\nrare\tO\nin\tO\npediatrics\tO\n.\tO\n\nThe\tO\nincidence\tO\ndepends\tO\non\tO\ndosage\tO\nbut\tO\nnot\tO\non\tO\nthe\tO\ntype\tO\nof\tO\nconsumed\tO\nnonionic\tO\nCM\tB-Chemical\n,\tO\nnor\tO\non\tO\nthe\tO\npresence\tO\nof\tO\ncyanosis\tB-Disease\n,\tO\nand\tO\nalthough\tO\nCIN\tB-Disease\nusually\tO\nis\tO\nreversible\tO\n,\tO\nmore\tO\nconcern\tO\nis\tO\nneeded\tO\nfor\tO\nthe\tO\nprevention\tO\nof\tO\nsuch\tO\na\tO\ncomplication\tO\nin\tO\nchildren\tO\n.\tO\n\nRenal\tO\nfunction\tO\nand\tO\nhemodynamics\tO\nduring\tO\nprolonged\tO\nisoflurane\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nin\tO\nhumans\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nisoflurane\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\non\tO\nglomerular\tO\nfunction\tO\nand\tO\nrenal\tO\nblood\tO\nflow\tO\nwas\tO\ninvestigated\tO\nin\tO\n20\tO\nhuman\tO\nsubjects\tO\n.\tO\n\nGlomerular\tO\nfiltration\tO\nrate\tO\n(\tO\nGFR\tO\n)\tO\nand\tO\neffective\tO\nrenal\tO\nplasma\tO\nflow\tO\n(\tO\nERPF\tO\n)\tO\nwere\tO\nmeasured\tO\nby\tO\ninulin\tO\nand\tO\npara\tB-Chemical\n-\tI-Chemical\naminohippurate\tI-Chemical\n(\tO\nPAH\tB-Chemical\n)\tO\nclearance\tO\n,\tO\nrespectively\tO\n.\tO\n\nAnesthesia\tO\nwas\tO\nmaintained\tO\nwith\tO\nfentanyl\tB-Chemical\n,\tO\nnitrous\tB-Chemical\noxide\tI-Chemical\n,\tO\noxygen\tB-Chemical\n,\tO\nand\tO\nisoflurane\tB-Chemical\n.\tO\n\nHypotension\tB-Disease\nwas\tO\ninduced\tO\nfor\tO\n236\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n15\tO\n.\tO\n1\tO\nmin\tO\nby\tO\nincreasing\tO\nthe\tO\nisoflurane\tB-Chemical\ninspired\tO\nconcentration\tO\nto\tO\nmaintain\tO\na\tO\nmean\tO\narterial\tO\npressure\tO\nof\tO\n59\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n4\tO\nmmHg\tO\n.\tO\n\nGFR\tO\nand\tO\nERPF\tO\ndecreased\tO\nwith\tO\nthe\tO\ninduction\tO\nof\tO\nanesthesia\tO\nbut\tO\nnot\tO\nsignificantly\tO\nmore\tO\nduring\tO\nhypotension\tB-Disease\n.\tO\n\nPostoperatively\tO\n,\tO\nERPF\tO\nreturned\tO\nto\tO\npreoperative\tO\nvalues\tO\n,\tO\nwhereas\tO\nGFR\tO\nwas\tO\nhigher\tO\nthan\tO\npreoperative\tO\nvalues\tO\n.\tO\n\nRenal\tO\nvascular\tO\nresistance\tO\nincreased\tO\nduring\tO\nanesthesia\tO\nbut\tO\ndecreased\tO\nwhen\tO\nhypotension\tB-Disease\nwas\tO\ninduced\tO\n,\tO\nallowing\tO\nthe\tO\nmaintenance\tO\nof\tO\nrenal\tO\nblood\tO\nflow\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nrenal\tO\ncompensatory\tO\nmechanisms\tO\nare\tO\npreserved\tO\nduring\tO\nisoflurane\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nand\tO\nthat\tO\nrenal\tO\nfunction\tO\nand\tO\nhemodynamics\tO\nquickly\tO\nreturn\tO\nto\tO\nnormal\tO\nwhen\tO\nnormotension\tO\nis\tO\nresumed\tO\n.\tO\n\nBrainstem\tB-Disease\ndysgenesis\tI-Disease\nin\tO\nan\tO\ninfant\tO\nprenatally\tO\nexposed\tO\nto\tO\ncocaine\tB-Chemical\n.\tO\n\nMany\tO\nauthors\tO\ndescribed\tO\nthe\tO\neffects\tO\non\tO\nthe\tO\nfetus\tO\nof\tO\nmaternal\tO\ncocaine\tB-Disease\nabuse\tI-Disease\nduring\tO\npregnancy\tO\n.\tO\n\nVasoconstriction\tO\nappears\tO\nto\tO\nbe\tO\nthe\tO\ncommon\tO\nmechanism\tO\nof\tO\naction\tO\nleading\tO\nto\tO\na\tO\nwide\tO\nrange\tO\nof\tO\nfetal\tB-Disease\nanomalies\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\non\tO\nan\tO\ninfant\tO\nwith\tO\nmultiple\tB-Disease\ncranial\tI-Disease\n-\tI-Disease\nnerve\tI-Disease\ninvolvement\tI-Disease\nattributable\tO\nto\tO\nbrainstem\tB-Disease\ndysgenesis\tI-Disease\n,\tO\nborn\tO\nto\tO\na\tO\ncocaine\tB-Disease\n-\tI-Disease\naddicted\tI-Disease\nmother\tO\n.\tO\n\nA\tO\ncross\tO\n-\tO\nsectional\tO\nevaluation\tO\nof\tO\nthe\tO\neffect\tO\nof\tO\nrisperidone\tB-Chemical\nand\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitors\tO\non\tO\nbone\tO\nmineral\tO\ndensity\tO\nin\tO\nboys\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthe\tO\neffect\tO\nof\tO\nrisperidone\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\non\tO\ntrabecular\tO\nbone\tO\nmineral\tO\ndensity\tO\n(\tO\nBMD\tO\n)\tO\nin\tO\nchildren\tO\nand\tO\nadolescents\tO\n.\tO\n\nMETHOD\tO\n:\tO\nMedically\tO\nhealthy\tO\n7\tO\n-\tO\nto\tO\n17\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmales\tO\nchronically\tO\ntreated\tO\n,\tO\nin\tO\na\tO\nnaturalistic\tO\nsetting\tO\n,\tO\nwith\tO\nrisperidone\tB-Chemical\nwere\tO\nrecruited\tO\nfor\tO\nthis\tO\ncross\tO\n-\tO\nsectional\tO\nstudy\tO\nthrough\tO\nchild\tO\npsychiatry\tO\noutpatient\tO\nclinics\tO\nbetween\tO\nNovember\tO\n2005\tO\nand\tO\nJune\tO\n2007\tO\n.\tO\n\nAnthropometric\tO\nmeasurements\tO\nand\tO\nlaboratory\tO\ntesting\tO\nwere\tO\nconducted\tO\n.\tO\n\nThe\tO\nclinical\tO\ndiagnoses\tO\nwere\tO\nbased\tO\non\tO\nchart\tO\nreview\tO\n,\tO\nand\tO\ndevelopmental\tO\nand\tO\ntreatment\tO\nhistory\tO\nwas\tO\nobtained\tO\nfrom\tO\nthe\tO\nmedical\tO\nrecord\tO\n.\tO\n\nVolumetric\tO\nBMD\tO\nof\tO\nthe\tO\nultradistal\tO\nradius\tO\nwas\tO\nmeasured\tO\nusing\tO\nperipheral\tO\nquantitative\tO\ncomputed\tO\ntomography\tO\n,\tO\nand\tO\nareal\tO\nBMD\tO\nof\tO\nthe\tO\nlumbar\tO\nspine\tO\nwas\tO\nestimated\tO\nusing\tO\ndual\tO\n-\tO\nenergy\tO\nx\tO\n-\tO\nray\tO\nabsorptiometry\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHyperprolactinemia\tB-Disease\nwas\tO\npresent\tO\nin\tO\n49\tO\n%\tO\nof\tO\n83\tO\nboys\tO\n(\tO\nn\tO\n=\tO\n41\tO\n)\tO\ntreated\tO\nwith\tO\nrisperidone\tB-Chemical\nfor\tO\na\tO\nmean\tO\nof\tO\n2\tO\n.\tO\n9\tO\nyears\tO\n.\tO\n\nSerum\tO\ntestosterone\tB-Chemical\nconcentration\tO\nincreased\tO\nwith\tO\npubertal\tO\nstatus\tO\nbut\tO\nwas\tO\nnot\tO\naffected\tO\nby\tO\nhyperprolactinemia\tB-Disease\n.\tO\n\nAs\tO\nexpected\tO\n,\tO\nbone\tO\nmineral\tO\ncontent\tO\nand\tO\nBMD\tO\nincreased\tO\nwith\tO\nsexual\tO\nmaturity\tO\n.\tO\n\nAfter\tO\nadjusting\tO\nfor\tO\nthe\tO\nstage\tO\nof\tO\nsexual\tO\ndevelopment\tO\nand\tO\nheight\tO\nand\tO\nBMI\tO\nz\tO\nscores\tO\n,\tO\nserum\tO\nprolactin\tO\nwas\tO\nnegatively\tO\nassociated\tO\nwith\tO\ntrabecular\tO\nvolumetric\tO\nBMD\tO\nat\tO\nthe\tO\nultradistal\tO\nradius\tO\n(\tO\nP\tO\n<\tO\n.\tO\n03\tO\n)\tO\n.\tO\n\nControlling\tO\nfor\tO\nrelevant\tO\ncovariates\tO\n,\tO\nwe\tO\nalso\tO\nfound\tO\ntreatment\tO\nwith\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitors\tO\n(\tO\nSSRIs\tO\n)\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nlower\tO\ntrabecular\tO\nBMD\tO\nat\tO\nthe\tO\nradius\tO\n(\tO\nP\tO\n=\tO\n.\tO\n03\tO\n)\tO\nand\tO\nBMD\tO\nz\tO\nscore\tO\nat\tO\nthe\tO\nlumbar\tO\nspine\tO\n(\tO\nP\tO\n<\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThese\tO\nfindings\tO\nbecame\tO\nmore\tO\nmarked\tO\nwhen\tO\nthe\tO\nanalysis\tO\nwas\tO\nrestricted\tO\nto\tO\nnon\tO\n-\tO\nHispanic\tO\nwhite\tO\npatients\tO\n.\tO\n\nOf\tO\n13\tO\ndocumented\tO\nfractures\tB-Disease\n,\tO\n3\tO\noccurred\tO\nafter\tO\nrisperidone\tB-Chemical\nand\tO\nSSRIs\tO\nwere\tO\nstarted\tO\n,\tO\nand\tO\nnone\tO\noccurred\tO\nin\tO\npatients\tO\nwith\tO\nhyperprolactinemia\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nstudy\tO\nto\tO\nlink\tO\nrisperidone\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\nand\tO\nSSRI\tO\ntreatment\tO\nto\tO\nlower\tO\nBMD\tO\nin\tO\nchildren\tO\nand\tO\nadolescents\tO\n.\tO\n\nFuture\tO\nresearch\tO\nshould\tO\nevaluate\tO\nthe\tO\nlongitudinal\tO\ncourse\tO\nof\tO\nthis\tO\nadverse\tO\nevent\tO\nto\tO\ndetermine\tO\nits\tO\ntemporal\tO\nstability\tO\nand\tO\nwhether\tO\na\tO\nhigher\tO\nfracture\tO\nrate\tO\nensues\tO\n.\tO\n\nFear\tO\n-\tO\npotentiated\tO\nstartle\tB-Disease\n,\tO\nbut\tO\nnot\tO\nlight\tO\n-\tO\nenhanced\tO\nstartle\tB-Disease\n,\tO\nis\tO\nenhanced\tO\nby\tO\nanxiogenic\tO\ndrugs\tO\n.\tO\n\nRATIONALE\tO\nAND\tO\nOBJECTIVES\tO\n:\tO\nThe\tO\nlight\tO\n-\tO\nenhanced\tO\nstartle\tB-Disease\nparadigm\tO\n(\tO\nLES\tO\n)\tO\nis\tO\nsuggested\tO\nto\tO\nmodel\tO\nanxiety\tB-Disease\n,\tO\nbecause\tO\nof\tO\nthe\tO\nnon\tO\n-\tO\nspecific\tO\ncue\tO\nand\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\neffect\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthe\tO\nfear\tO\n-\tO\npotentiated\tO\nstartle\tB-Disease\n(\tO\nFPS\tO\n)\tO\nis\tO\nsuggested\tO\nto\tO\nmodel\tO\nconditioned\tO\nfear\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\npharmacological\tO\nprofiles\tO\nof\tO\nthese\tO\ntwo\tO\nparadigms\tO\nare\tO\nvery\tO\nsimilar\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\ninvestigated\tO\nthe\tO\neffects\tO\nof\tO\nputative\tO\nanxiogenic\tO\ndrugs\tO\non\tO\nLES\tO\nand\tO\nFPS\tO\nand\tO\naimed\tO\nat\tO\ndetermining\tO\nthe\tO\nsensitivity\tO\nof\tO\nLES\tO\nfor\tO\nanxiogenic\tO\ndrugs\tO\nand\tO\nto\tO\npotentially\tO\nshowing\tO\na\tO\npharmacological\tO\ndifferentiation\tO\nbetween\tO\nthese\tO\ntwo\tO\nparadigms\tO\n.\tO\n\nMETHODS\tO\n:\tO\nMale\tO\nWistar\tO\nrats\tO\nreceived\tO\neach\tO\ndose\tO\nof\tO\nthe\tO\nalpha\tO\n(\tO\n2\tO\n)\tO\n-\tO\nadrenoceptor\tO\nantagonist\tO\nyohimbine\tB-Chemical\n(\tO\n0\tO\n.\tO\n25\tO\n-\tO\n1\tO\n.\tO\n0mg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nthe\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n(\tO\n2C\tO\n)\tO\nreceptor\tO\nagonist\tO\nm\tB-Chemical\n-\tI-Chemical\nchlorophenylpiperazine\tI-Chemical\n(\tO\nmCPP\tB-Chemical\n,\tO\n0\tO\n.\tO\n5\tO\n-\tO\n2\tO\n.\tO\n0mg\tO\n/\tO\nkg\tO\n)\tO\nor\tO\nthe\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\ninverse\tO\nreceptor\tO\nagonist\tO\npentylenetetrazole\tB-Chemical\n(\tO\nPTZ\tB-Chemical\n,\tO\n3\tO\n-\tO\n30mg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\nwere\tO\nsubsequently\tO\ntested\tO\nin\tO\neither\tO\nLES\tO\nor\tO\nFPS\tO\n.\tO\n\nRESULTS\tO\n:\tO\nNone\tO\nof\tO\nthe\tO\ndrugs\tO\nenhanced\tO\nLES\tO\n,\tO\nwhereas\tO\nmCPP\tB-Chemical\nincreased\tO\npercentage\tO\nFPS\tO\nand\tO\nyohimbine\tB-Chemical\nincreased\tO\nabsolute\tO\nFPS\tO\nvalues\tO\n.\tO\n\nFurthermore\tO\n,\tO\nyohimbine\tB-Chemical\nincreased\tO\nbaseline\tO\nstartle\tB-Disease\namplitude\tO\nin\tO\nthe\tO\nLES\tO\n,\tO\nwhile\tO\nmCPP\tB-Chemical\nsuppressed\tO\nbaseline\tO\nstartle\tB-Disease\nin\tO\nboth\tO\nthe\tO\nLES\tO\nand\tO\nFPS\tO\nand\tO\nPTZ\tB-Chemical\nsuppressed\tO\nbaseline\tO\nstartle\tB-Disease\nin\tO\nthe\tO\nFPS\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\ncontrast\tO\nto\tO\nfindings\tO\nin\tO\nthe\tO\nFPS\tO\nparadigm\tO\n,\tO\nnone\tO\nof\tO\nthe\tO\ndrugs\tO\nwere\tO\nable\tO\nto\tO\nexacerbate\tO\nthe\tO\nLES\tO\nresponse\tO\n.\tO\n\nThus\tO\n,\tO\na\tO\nclear\tO\npharmacological\tO\ndifferentiation\tO\nwas\tO\nfound\tO\nbetween\tO\nLES\tO\nand\tO\nFPS\tO\n.\tO\n\nRosaceiform\tO\ndermatitis\tB-Disease\nassociated\tO\nwith\tO\ntopical\tO\ntacrolimus\tB-Chemical\ntreatment\tO\n.\tO\n\nWe\tO\ndescribe\tO\nherein\tO\n3\tO\npatients\tO\nwho\tO\ndeveloped\tO\nrosacea\tB-Disease\n-\tO\nlike\tO\ndermatitis\tB-Disease\neruptions\tB-Disease\nwhile\tO\nusing\tO\n0\tO\n.\tO\n03\tO\n%\tO\nor\tO\n0\tO\n.\tO\n1\tO\n%\tO\ntacrolimus\tB-Chemical\nointment\tO\nfor\tO\nfacial\tB-Disease\ndermatitis\tI-Disease\n.\tO\n\nSkin\tO\nbiopsy\tO\nspecimens\tO\nshowed\tO\ntelangiectasia\tB-Disease\nand\tO\nnoncaseating\tO\nepithelioid\tO\ngranulomatous\tO\ntissue\tO\nformation\tO\nin\tO\nthe\tO\npapillary\tO\nto\tO\nmid\tO\ndermis\tO\n.\tO\n\nContinuous\tO\ntopical\tO\nuse\tO\nof\tO\nimmunomodulators\tO\nsuch\tO\nas\tO\ntacrolimus\tB-Chemical\nor\tO\npimecrolimus\tB-Chemical\nshould\tO\nbe\tO\nregarded\tO\nas\tO\na\tO\npotential\tO\ncause\tO\nof\tO\nrosaceiform\tO\ndermatitis\tB-Disease\n,\tO\nalthough\tO\nmany\tO\ncases\tO\nhave\tO\nnot\tO\nbeen\tO\nreported\tO\n.\tO\n\nCoenzyme\tB-Chemical\nQ10\tI-Chemical\ntreatment\tO\nameliorates\tO\nacute\tO\ncisplatin\tB-Chemical\nnephrotoxicity\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nThe\tO\nnephroprotective\tO\neffect\tO\nof\tO\ncoenzyme\tB-Chemical\nQ10\tI-Chemical\nwas\tO\ninvestigated\tO\nin\tO\nmice\tO\nwith\tO\nacute\tB-Disease\nrenal\tI-Disease\ninjury\tI-Disease\ninduced\tO\nby\tO\na\tO\nsingle\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tO\nof\tO\ncisplatin\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nCoenzyme\tB-Chemical\nQ10\tI-Chemical\ntreatment\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nwas\tO\napplied\tO\nfor\tO\n6\tO\nconsecutive\tO\ndays\tO\n,\tO\nstarting\tO\n1\tO\nday\tO\nbefore\tO\ncisplatin\tB-Chemical\nadministration\tO\n.\tO\n\nCoenzyme\tB-Chemical\nQ10\tI-Chemical\nsignificantly\tO\nreduced\tO\nblood\tB-Chemical\nurea\tI-Chemical\nnitrogen\tI-Chemical\nand\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\nwhich\tO\nwere\tO\nincreased\tO\nby\tO\ncisplatin\tB-Chemical\n.\tO\n\nCoenzyme\tB-Chemical\nQ10\tI-Chemical\nsignificantly\tO\ncompensated\tO\ndeficits\tO\nin\tO\nthe\tO\nantioxidant\tO\ndefense\tO\nmechanisms\tO\n(\tO\nreduced\tB-Chemical\nglutathione\tI-Chemical\nlevel\tO\nand\tO\nsuperoxide\tB-Chemical\ndismutase\tO\nactivity\tO\n)\tO\n,\tO\nsuppressed\tO\nlipid\tO\nperoxidation\tO\n,\tO\ndecreased\tO\nthe\tO\nelevations\tO\nof\tO\ntumor\tB-Disease\nnecrosis\tB-Disease\nfactor\tO\n-\tO\nalpha\tO\n,\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nand\tO\nplatinum\tB-Chemical\nion\tO\nconcentration\tO\n,\tO\nand\tO\nattenuated\tO\nthe\tO\nreductions\tO\nof\tO\nselenium\tB-Chemical\nand\tO\nzinc\tB-Chemical\nions\tO\nin\tO\nrenal\tO\ntissue\tO\nresulted\tO\nfrom\tO\ncisplatin\tB-Chemical\nadministration\tO\n.\tO\n\nAlso\tO\n,\tO\nhistopathological\tO\nrenal\tB-Disease\ntissue\tI-Disease\ndamage\tI-Disease\nmediated\tO\nby\tO\ncisplatin\tB-Chemical\nwas\tO\nameliorated\tO\nby\tO\ncoenzyme\tB-Chemical\nQ10\tI-Chemical\ntreatment\tO\n.\tO\n\nImmunohistochemical\tO\nanalysis\tO\nrevealed\tO\nthat\tO\ncoenzyme\tB-Chemical\nQ10\tI-Chemical\nsignificantly\tO\ndecreased\tO\nthe\tO\ncisplatin\tB-Chemical\n-\tO\ninduced\tO\noverexpression\tO\nof\tO\ninducible\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsynthase\tO\n,\tO\nnuclear\tO\nfactor\tO\n-\tO\nkappaB\tO\n,\tO\ncaspase\tO\n-\tO\n3\tO\nand\tO\np53\tO\nin\tO\nrenal\tO\ntissue\tO\n.\tO\n\nIt\tO\nwas\tO\nconcluded\tO\nthat\tO\ncoenzyme\tB-Chemical\nQ10\tI-Chemical\nrepresents\tO\na\tO\npotential\tO\ntherapeutic\tO\noption\tO\nto\tO\nprotect\tO\nagainst\tO\nacute\tO\ncisplatin\tB-Chemical\nnephrotoxicity\tB-Disease\ncommonly\tO\nencountered\tO\nin\tO\nclinical\tO\npractice\tO\n.\tO\n\nReversible\tO\ncholestasis\tB-Disease\nwith\tO\nbile\tB-Disease\nduct\tI-Disease\ninjury\tI-Disease\nfollowing\tO\nazathioprine\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\ncase\tO\nreport\tO\n.\tO\n\nA\tO\n67\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\n,\tO\nwith\tO\nprimary\tO\npolymyositis\tB-Disease\nand\tO\nwithout\tO\nprevious\tO\nevidence\tO\nof\tO\nliver\tB-Disease\ndisease\tI-Disease\n,\tO\ndeveloped\tO\nclinical\tO\nand\tO\nbiochemical\tO\nfeatures\tO\nof\tO\nsevere\tO\ncholestasis\tB-Disease\n3\tO\nmonths\tO\nafter\tO\ninitiation\tO\nof\tO\nazathioprine\tB-Chemical\ntherapy\tO\n.\tO\n\nLiver\tO\nbiopsy\tO\nshowed\tO\ncholestasis\tB-Disease\nwith\tO\nboth\tO\ncytological\tO\nand\tO\narchitectural\tO\nalterations\tO\nof\tO\ninterlobular\tO\nbile\tO\nducts\tO\n.\tO\n\nAzathioprine\tB-Chemical\nwithdrawal\tO\nresulted\tO\nafter\tO\n7\tO\nweeks\tO\nin\tO\nthe\tO\nresolution\tO\nof\tO\nclinical\tO\nand\tO\nbiochemical\tO\nabnormalities\tO\n.\tO\n\nIt\tO\nis\tO\nbelieved\tO\nthat\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\nreported\tO\ncase\tO\nof\tO\nreversible\tO\nazathioprine\tB-Chemical\n-\tO\ninduced\tO\ncholestasis\tB-Disease\nassociated\tO\nwith\tO\nhistological\tO\nevidence\tO\nof\tO\nbile\tB-Disease\nduct\tI-Disease\ninjury\tI-Disease\n.\tO\n\nDopamine\tB-Chemical\nis\tO\nnot\tO\nessential\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\n.\tO\n\nIt\tO\nis\tO\nwidely\tO\nbelieved\tO\nthat\tO\ndopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\nmediates\tO\nmethamphetamine\tB-Chemical\n(\tO\nMETH\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ntoxicity\tB-Disease\nto\tO\nbrain\tO\ndopaminergic\tO\nneurons\tO\n,\tO\nbecause\tO\ndrugs\tO\nthat\tO\ninterfere\tO\nwith\tO\nDA\tB-Chemical\nneurotransmission\tO\ndecrease\tO\ntoxicity\tB-Disease\n,\tO\nwhereas\tO\ndrugs\tO\nthat\tO\nincrease\tO\nDA\tB-Chemical\nneurotransmission\tO\nenhance\tO\ntoxicity\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\ntemperature\tO\neffects\tO\nof\tO\ndrugs\tO\nthat\tO\nhave\tO\nbeen\tO\nused\tO\nto\tO\nmanipulate\tO\nbrain\tO\nDA\tB-Chemical\nneurotransmission\tO\nconfound\tO\ninterpretation\tO\nof\tO\nthe\tO\ndata\tO\n.\tO\n\nHere\tO\nwe\tO\nshow\tO\nthat\tO\nthe\tO\nrecently\tO\nreported\tO\nability\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\ndihydroxyphenylalanine\tI-Chemical\nto\tO\nreverse\tO\nthe\tO\nprotective\tO\neffect\tO\nof\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\npara\tI-Chemical\n-\tI-Chemical\ntyrosine\tI-Chemical\non\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\nDA\tB-Chemical\nneurotoxicity\tB-Disease\nis\tO\nalso\tO\nconfounded\tO\nby\tO\ndrug\tO\neffects\tO\non\tO\nbody\tO\ntemperature\tO\n.\tO\n\nFurther\tO\n,\tO\nwe\tO\nshow\tO\nthat\tO\nmice\tO\ngenetically\tO\nengineered\tO\nto\tO\nbe\tO\ndeficient\tO\nin\tO\nbrain\tO\nDA\tB-Chemical\ndevelop\tO\nMETH\tB-Chemical\nneurotoxicity\tB-Disease\n,\tO\nas\tO\nlong\tO\nas\tO\nthe\tO\nthermic\tO\neffects\tO\nof\tO\nMETH\tB-Chemical\nare\tO\npreserved\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nwe\tO\ndemonstrate\tO\nthat\tO\nmice\tO\ngenetically\tO\nengineered\tO\nto\tO\nhave\tO\nunilateral\tO\nbrain\tO\nDA\tB-Chemical\ndeficits\tO\ndevelop\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\ndopaminergic\tB-Disease\ndeficits\tI-Disease\nthat\tO\nare\tO\nof\tO\ncomparable\tO\nmagnitude\tO\non\tO\nboth\tO\nsides\tO\nof\tO\nthe\tO\nbrain\tO\n.\tO\n\nTaken\tO\ntogether\tO\n,\tO\nthese\tO\nfindings\tO\ndemonstrate\tO\nthat\tO\nDA\tB-Chemical\nis\tO\nnot\tO\nessential\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\ndopaminergic\tO\nneurotoxicity\tB-Disease\nand\tO\nsuggest\tO\nthat\tO\nmechanisms\tO\nindependent\tO\nof\tO\nDA\tB-Chemical\nwarrant\tO\nmore\tO\nintense\tO\ninvestigation\tO\n.\tO\n\nSwallowing\tO\n-\tO\ninduced\tO\natrial\tB-Disease\ntachyarrhythmia\tI-Disease\ntriggered\tO\nby\tO\nsalbutamol\tB-Chemical\n:\tO\ncase\tO\nreport\tO\nand\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\n.\tO\n\nCASE\tO\n:\tO\nA\tO\n49\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\nexperienced\tO\nchest\tO\ndiscomfort\tO\nwhile\tO\nswallowing\tO\n.\tO\n\nOn\tO\nelectrocardiogram\tO\n,\tO\nepisodes\tO\nof\tO\natrial\tB-Disease\ntachyarrhythmia\tI-Disease\nwere\tO\nrecorded\tO\nimmediately\tO\nafter\tO\nswallowing\tO\n;\tO\n24\tO\n-\tO\nhour\tO\nHolter\tO\nmonitoring\tO\nrecorded\tO\nseveral\tO\nevents\tO\n.\tO\n\nThe\tO\narrhythmia\tB-Disease\nresolved\tO\nafter\tO\ntherapy\tO\nwith\tO\natenolol\tB-Chemical\n,\tO\nbut\tO\nrecurred\tO\na\tO\nyear\tO\nlater\tO\n.\tO\n\nThe\tO\npatient\tO\nnoticed\tO\nthat\tO\nbefore\tO\nthese\tO\nepisodes\tO\nhe\tO\nhad\tO\nbeen\tO\nusing\tO\nan\tO\ninhalator\tO\nof\tO\nsalbutamol\tB-Chemical\n.\tO\n\nAfter\tO\nstopping\tO\nthe\tO\nbeta\tO\n-\tO\nagonist\tO\n,\tO\nand\tO\nafter\tO\na\tO\nweek\tO\nwith\tO\nthe\tO\natenolol\tB-Chemical\n,\tO\nthe\tO\narrhythmia\tB-Disease\ndisappeared\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nSwallowing\tO\n-\tO\ninduced\tO\natrial\tB-Disease\ntachyarrhythmia\tI-Disease\n(\tO\nSIAT\tB-Disease\n)\tO\nis\tO\na\tO\nrare\tO\nphenomenon\tO\n.\tO\n\nFewer\tO\nthan\tO\n50\tO\ncases\tO\nof\tO\nSIAT\tB-Disease\nhave\tO\nbeen\tO\ndescribed\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nThis\tO\narticle\tO\nsummarizes\tO\nall\tO\nthe\tO\ncases\tO\npublished\tO\n,\tO\ncreating\tO\na\tO\ncomprehensive\tO\nreview\tO\nof\tO\nthe\tO\ncurrent\tO\nknowledge\tO\nand\tO\napproach\tO\nto\tO\nSIAT\tB-Disease\n.\tO\n\nIt\tO\ndiscusses\tO\ndemographics\tO\n,\tO\nclinical\tO\ncharacteristics\tO\nand\tO\ntypes\tO\nof\tO\narrhythmia\tB-Disease\n,\tO\npostulated\tO\nmechanisms\tO\nof\tO\nSIAT\tB-Disease\n,\tO\nand\tO\ndifferent\tO\ntreatment\tO\npossibilities\tO\nsuch\tO\nas\tO\nmedications\tO\n,\tO\nsurgery\tO\n,\tO\nand\tO\nradiofrequency\tO\ncatheter\tO\nablation\tO\n(\tO\nRFCA\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nSalbutamol\tB-Chemical\nis\tO\npresented\tO\nhere\tO\nas\tO\na\tO\npossible\tO\ntrigger\tO\nfor\tO\nSIAT\tB-Disease\n.\tO\n\nAlthough\tO\nit\tO\nis\tO\ndifficult\tO\nto\tO\ndefine\tO\ncausality\tO\nin\tO\na\tO\ncase\tO\nreport\tO\n,\tO\nit\tO\nis\tO\nlogical\tO\nto\tO\nthink\tO\nthat\tO\na\tO\nbeta\tO\n-\tO\nagonist\tO\nlike\tO\nsalbutamol\tB-Chemical\n(\tO\nknown\tO\nto\tO\ninduce\tO\ntachycardia\tB-Disease\n)\tO\nmay\tO\nbe\tO\nthe\tO\ntrigger\tO\nof\tO\nadrenergic\tO\nreflexes\tO\noriginating\tO\nin\tO\nthe\tO\nesophagus\tO\nwhile\tO\nswallowing\tO\nand\tO\nthat\tO\na\tO\nbeta\tO\n-\tO\nblocker\tO\nsuch\tO\nas\tO\natenolol\tB-Chemical\n(\tO\nthat\tO\nblocks\tO\nthe\tO\nadrenergic\tO\nactivity\tO\n)\tO\nmay\tO\nrelieve\tO\nit\tO\n.\tO\n\nThe\tO\nability\tO\nof\tO\ninsulin\tO\ntreatment\tO\nto\tO\nreverse\tO\nor\tO\nprevent\tO\nthe\tO\nchanges\tO\nin\tO\nurinary\tO\nbladder\tO\nfunction\tO\ncaused\tO\nby\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\n.\tO\n\n1\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ninsulin\tO\ntreatment\tO\non\tO\nin\tO\nvivo\tO\nand\tO\nin\tO\nvitro\tO\nurinary\tO\nbladder\tO\nfunction\tO\nin\tO\nstreptozotocin\tB-Chemical\n-\tO\ndiabetic\tB-Disease\nrats\tO\nwere\tO\ninvestigated\tO\n.\tO\n\n2\tO\n.\tO\n\nDiabetes\tB-Disease\nof\tO\n2\tO\nmonths\tO\nduration\tO\nresulted\tO\nin\tO\ndecreases\tO\nin\tO\nbody\tO\nweight\tO\nand\tO\nincreases\tO\nin\tO\nfluid\tO\nconsumption\tO\n,\tO\nurine\tO\nvolume\tO\n,\tO\nfrequency\tO\nof\tO\nmicturition\tO\n,\tO\nand\tO\naverage\tO\nvolume\tO\nper\tO\nmicturition\tO\n;\tO\neffects\tO\nwhich\tO\nwere\tO\nprevented\tO\nby\tO\ninsulin\tO\ntreatment\tO\n.\tO\n\n3\tO\n.\tO\n\nInsulin\tO\ntreatment\tO\nalso\tO\nprevented\tO\nthe\tO\nincreases\tO\nin\tO\ncontractile\tO\nresponses\tO\nof\tO\nbladder\tO\nbody\tO\nstrips\tO\nfrom\tO\ndiabetic\tB-Disease\nrats\tO\nto\tO\nnerve\tO\nstimulation\tO\n,\tO\nATP\tB-Chemical\n,\tO\nand\tO\nbethanechol\tB-Chemical\n.\tO\n\n4\tO\n.\tO\n\nDiabetes\tB-Disease\nof\tO\n4\tO\nmonths\tO\nduration\tO\nalso\tO\nresulted\tO\nin\tO\ndecreases\tO\nin\tO\nbody\tO\nweight\tO\n,\tO\nand\tO\nincreases\tO\nin\tO\nfluid\tO\nconsumption\tO\n,\tO\nurine\tO\nvolume\tO\n,\tO\nfrequency\tO\nof\tO\nmicturition\tO\n,\tO\nand\tO\naverage\tO\nvolume\tO\nper\tO\nmicturition\tO\n,\tO\neffects\tO\nwhich\tO\nwere\tO\nreversed\tO\nby\tO\ninsulin\tO\ntreatment\tO\nfor\tO\nthe\tO\nfinal\tO\n2\tO\nmonths\tO\nof\tO\nthe\tO\nstudy\tO\n.\tO\n\n5\tO\n.\tO\n\nInsulin\tO\ntreatment\tO\nreversed\tO\nthe\tO\nincreases\tO\nin\tO\ncontractile\tO\nresponses\tO\nof\tO\nbladder\tO\nbody\tO\nstrips\tO\nfrom\tO\ndiabetic\tB-Disease\nrats\tO\nto\tO\nnerve\tO\nstimulation\tO\n,\tO\nATP\tB-Chemical\n,\tO\nand\tO\nbethanechol\tB-Chemical\n.\tO\n\n6\tO\n.\tO\n\nThe\tO\ndata\tO\nindicate\tO\nthat\tO\nthe\tO\neffects\tO\nof\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\ndiabetes\tB-Disease\non\tO\nurinary\tO\nbladder\tO\nfunction\tO\nare\tO\nboth\tO\nprevented\tO\nand\tO\nreversed\tO\nby\tO\ninsulin\tO\ntreatment\tO\n.\tO\n\nGlutamatergic\tO\nneurotransmission\tO\nmediated\tO\nby\tO\nNMDA\tB-Chemical\nreceptors\tO\nin\tO\nthe\tO\ninferior\tO\ncolliculus\tO\ncan\tO\nmodulate\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n.\tO\n\nThe\tO\ninferior\tO\ncolliculus\tO\n(\tO\nIC\tO\n)\tO\nis\tO\nprimarily\tO\ninvolved\tO\nin\tO\nthe\tO\nprocessing\tO\nof\tO\nauditory\tO\ninformation\tO\n,\tO\nbut\tO\nit\tO\nis\tO\ndistinguished\tO\nfrom\tO\nother\tO\nauditory\tO\nnuclei\tO\nin\tO\nthe\tO\nbrainstem\tO\nby\tO\nits\tO\nconnections\tO\nwith\tO\nstructures\tO\nof\tO\nthe\tO\nmotor\tO\nsystem\tO\n.\tO\n\nFunctional\tO\nevidence\tO\nrelating\tO\nthe\tO\nIC\tO\nto\tO\nmotor\tO\nbehavior\tO\nderives\tO\nfrom\tO\nexperiments\tO\nshowing\tO\nthat\tO\nactivation\tO\nof\tO\nthe\tO\nIC\tO\nby\tO\nelectrical\tO\nstimulation\tO\nor\tO\nexcitatory\tO\namino\tB-Chemical\nacid\tI-Chemical\nmicroinjection\tO\ncauses\tO\nfreezing\tO\n,\tO\nescape\tO\n-\tO\nlike\tO\nbehavior\tO\n,\tO\nand\tO\nimmobility\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nnature\tO\nof\tO\nthis\tO\nimmobility\tO\nis\tO\nstill\tO\nunclear\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nexamined\tO\nthe\tO\ninfluence\tO\nof\tO\nexcitatory\tO\namino\tB-Chemical\nacid\tI-Chemical\n-\tO\nmediated\tO\nmechanisms\tO\nin\tO\nthe\tO\nIC\tO\non\tO\nthe\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nthe\tO\ndopamine\tB-Chemical\nreceptor\tO\nblocker\tO\nhaloperidol\tB-Chemical\nadministered\tO\nsystemically\tO\n(\tO\n1\tO\nor\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nin\tO\nrats\tO\n.\tO\n\nHaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nwas\tO\nchallenged\tO\nwith\tO\nprior\tO\nintracollicular\tO\nmicroinjections\tO\nof\tO\nglutamate\tB-Chemical\nNMDA\tB-Chemical\nreceptor\tO\nantagonists\tO\n,\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n(\tO\n15\tO\nor\tO\n30\tO\nmmol\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\n)\tO\nand\tO\nAP7\tB-Chemical\n(\tO\n10\tO\nor\tO\n20\tO\nnmol\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\n)\tO\n,\tO\nor\tO\nof\tO\nthe\tO\nNMDA\tB-Chemical\nreceptor\tO\nagonist\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nd\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n,\tO\n20\tO\nor\tO\n30\tO\nnmol\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\n)\tO\n.\tO\n\nThe\tO\nresults\tO\nshowed\tO\nthat\tO\nintracollicular\tO\nmicroinjection\tO\nof\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\nand\tO\nAP7\tB-Chemical\nprevious\tO\nto\tO\nsystemic\tO\ninjections\tO\nof\tO\nhaloperidol\tB-Chemical\nsignificantly\tO\nattenuated\tO\nthe\tO\ncatalepsy\tB-Disease\n,\tO\nas\tO\nindicated\tO\nby\tO\na\tO\nreduced\tO\nlatency\tO\nto\tO\nstep\tO\ndown\tO\nfrom\tO\na\tO\nhorizontal\tO\nbar\tO\n.\tO\n\nAccordingly\tO\n,\tO\nintracollicular\tO\nmicroinjection\tO\nof\tO\nNMDA\tB-Chemical\nincreased\tO\nthe\tO\nlatency\tO\nto\tO\nstep\tO\ndown\tO\nthe\tO\nbar\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nglutamate\tB-Chemical\n-\tO\nmediated\tO\nmechanisms\tO\nin\tO\nthe\tO\nneural\tO\ncircuits\tO\nat\tO\nthe\tO\nIC\tO\nlevel\tO\ninfluence\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nand\tO\nparticipate\tO\nin\tO\nthe\tO\nregulation\tO\nof\tO\nmotor\tO\nactivity\tO\n.\tO\n\nSevere\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\npatient\tO\non\tO\namiodarone\tB-Chemical\npresenting\tO\nwith\tO\nmyxedemic\tB-Disease\ncoma\tI-Disease\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\ncase\tO\nreport\tO\nof\tO\nmyxedema\tB-Disease\ncoma\tI-Disease\nsecondary\tO\nto\tO\namiodarone\tB-Chemical\n-\tO\ninduced\tO\nhypothyroidism\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nsevere\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n(\tO\nCHF\tB-Disease\n)\tO\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\nand\tO\nafter\tO\nreviewing\tO\nthe\tO\nliterature\tO\nthere\tO\nis\tO\none\tO\ncase\tO\nreport\tO\nof\tO\nmyxedema\tB-Disease\ncoma\tI-Disease\nduring\tO\nlong\tO\nterm\tO\namiodarone\tB-Chemical\ntherapy\tO\n.\tO\n\nMyxedema\tB-Disease\ncoma\tI-Disease\nis\tO\na\tO\nlife\tO\nthreatening\tO\ncondition\tO\nthat\tO\ncarries\tO\na\tO\nmortality\tO\nreaching\tO\nas\tO\nhigh\tO\nas\tO\n20\tO\n%\tO\nwith\tO\ntreatment\tO\n.\tO\n\nThe\tO\ncondition\tO\nis\tO\ntreated\tO\nwith\tO\nintravenous\tO\nthyroxine\tB-Chemical\n(\tO\nT4\tB-Chemical\n)\tO\nor\tO\nintravenous\tO\ntri\tB-Chemical\n-\tI-Chemical\niodo\tI-Chemical\n-\tI-Chemical\nthyronine\tI-Chemical\n(\tO\nT3\tB-Chemical\n)\tO\n.\tO\n\nPatients\tO\nwith\tO\nCHF\tB-Disease\non\tO\namiodarone\tB-Chemical\nmay\tO\nsuffer\tO\nserious\tO\nmorbidity\tO\nand\tO\nmortality\tO\nfrom\tO\nhypothyroidism\tB-Disease\n,\tO\nand\tO\nthus\tO\nmay\tO\ndeserve\tO\ncloser\tO\nfollow\tO\nup\tO\nfor\tO\nthyroid\tO\nstimulating\tO\nhormone\tO\n(\tO\nTSH\tO\n)\tO\nlevels\tO\n.\tO\n\nThis\tO\ncase\tO\nreport\tO\ncarries\tO\nan\tO\nimportant\tO\nclinical\tO\napplication\tO\ngiven\tO\nthe\tO\nfrequent\tO\nusage\tO\nof\tO\namiodarone\tB-Chemical\namong\tO\nCHF\tB-Disease\npatients\tO\n.\tO\n\nThe\tO\nmyriad\tO\nclinical\tO\npresentation\tO\nof\tO\nmyxedema\tB-Disease\ncoma\tI-Disease\nand\tO\nits\tO\nserious\tO\nmorbidity\tO\nand\tO\nmortality\tO\nstresses\tO\nthe\tO\nneed\tO\nto\tO\nsuspect\tO\nthis\tO\nclinical\tO\nsyndrome\tO\namong\tO\nCHF\tB-Disease\npatients\tO\npresenting\tO\nwith\tO\nhypotension\tB-Disease\n,\tO\nweakness\tB-Disease\nor\tO\nother\tO\nunexplained\tO\nsymptoms\tO\n.\tO\n\nEffects\tO\nof\tO\nactive\tO\nconstituents\tO\nof\tO\nCrocus\tO\nsativus\tO\nL\tO\n.\tO\n,\tO\ncrocin\tB-Chemical\non\tO\nstreptozocin\tB-Chemical\n-\tO\ninduced\tO\nmodel\tO\nof\tO\nsporadic\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\ninvolvement\tO\nof\tO\nwater\tO\n-\tO\nsoluble\tO\ncarotenoids\tB-Chemical\n,\tO\ncrocins\tB-Chemical\n,\tO\nas\tO\nthe\tO\nmain\tO\nand\tO\nactive\tO\ncomponents\tO\nof\tO\nCrocus\tO\nsativus\tO\nL\tO\n.\tO\nextract\tO\nin\tO\nlearning\tO\nand\tO\nmemory\tO\nprocesses\tO\nhas\tO\nbeen\tO\nproposed\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthe\tO\neffect\tO\nof\tO\ncrocins\tB-Chemical\non\tO\nsporadic\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\ninduced\tO\nby\tO\nintracerebroventricular\tO\n(\tO\nicv\tO\n)\tO\nstreptozocin\tB-Chemical\n(\tO\nSTZ\tB-Chemical\n)\tO\nin\tO\nmale\tO\nrats\tO\nwas\tO\ninvestigated\tO\n.\tO\n\nMETHODS\tO\n:\tO\nMale\tO\nadult\tO\nWistar\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n90\tO\nand\tO\n260\tO\n-\tO\n290\tO\ng\tO\n)\tO\nwere\tO\ndivided\tO\ninto\tO\n1\tO\n,\tO\ncontrol\tO\n;\tO\n2\tO\nand\tO\n3\tO\n,\tO\ncrocins\tB-Chemical\n(\tO\n15\tO\nand\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n;\tO\n4\tO\n,\tO\nSTZ\tB-Chemical\n;\tO\n5\tO\nand\tO\n6\tO\n,\tO\nSTZ\tB-Chemical\n+\tO\ncrocins\tB-Chemical\n(\tO\n15\tO\nand\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ngroups\tO\n.\tO\n\nIn\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\ngroups\tO\n,\tO\nrats\tO\nwere\tO\ninjected\tO\nwith\tO\nSTZ\tB-Chemical\n-\tO\nicv\tO\nbilaterally\tO\n(\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nin\tO\nfirst\tO\nday\tO\nand\tO\n3\tO\ndays\tO\nlater\tO\n,\tO\na\tO\nsimilar\tO\nSTZ\tB-Chemical\n-\tO\nicv\tO\napplication\tO\nwas\tO\nrepeated\tO\n.\tO\n\nIn\tO\nSTZ\tB-Chemical\n+\tO\ncrocin\tB-Chemical\nanimal\tO\ngroups\tO\n,\tO\ncrocin\tB-Chemical\nwas\tO\napplied\tO\nin\tO\ndoses\tO\nof\tO\n15\tO\nand\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\none\tO\nday\tO\npre\tO\n-\tO\nsurgery\tO\nand\tO\ncontinued\tO\nfor\tO\nthree\tO\nweeks\tO\n.\tO\n\nPrescription\tO\nof\tO\ncrocin\tB-Chemical\nin\tO\neach\tO\ndose\tO\nwas\tO\nrepeated\tO\nonce\tO\nfor\tO\ntwo\tO\ndays\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nlearning\tO\nand\tO\nmemory\tO\nperformance\tO\nwas\tO\nassessed\tO\nusing\tO\npassive\tO\navoidance\tO\nparadigm\tO\n,\tO\nand\tO\nfor\tO\nspatial\tO\ncognition\tO\nevaluation\tO\n,\tO\nY\tO\n-\tO\nmaze\tO\ntask\tO\nwas\tO\nused\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIt\tO\nwas\tO\nfound\tO\nout\tO\nthat\tO\ncrocin\tB-Chemical\n(\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n-\tO\ntreated\tO\nSTZ\tB-Chemical\n-\tO\ninjected\tO\nrats\tO\nshow\tO\nhigher\tO\ncorrect\tO\nchoices\tO\nand\tO\nlower\tO\nerrors\tO\nin\tO\nY\tO\n-\tO\nmaze\tO\nthan\tO\nvehicle\tO\n-\tO\ntreated\tO\nSTZ\tB-Chemical\n-\tO\ninjected\tO\nrats\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\ncrocin\tB-Chemical\nin\tO\nthe\tO\nmentioned\tO\ndose\tO\ncould\tO\nsignificantly\tO\nattenuated\tO\nlearning\tB-Disease\nand\tI-Disease\nmemory\tI-Disease\nimpairment\tI-Disease\nin\tO\ntreated\tO\nSTZ\tB-Chemical\n-\tO\ninjected\tO\ngroup\tO\nin\tO\npassive\tO\navoidance\tO\ntest\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nTherefore\tO\n,\tO\nthese\tO\nresults\tO\ndemonstrate\tO\nthe\tO\neffectiveness\tO\nof\tO\ncrocin\tB-Chemical\n(\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nin\tO\nantagonizing\tO\nthe\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\ncaused\tO\nby\tO\nSTZ\tB-Chemical\n-\tO\nicv\tO\nin\tO\nrats\tO\nand\tO\nits\tO\npotential\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nneurodegenerative\tB-Disease\ndiseases\tI-Disease\nsuch\tO\nas\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nSerotonin\tB-Chemical\n6\tO\nreceptor\tO\ngene\tO\nis\tO\nassociated\tO\nwith\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\nin\tO\na\tO\nJapanese\tO\npopulation\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAltered\tO\nserotonergic\tO\nneural\tO\ntransmission\tO\nis\tO\nhypothesized\tO\nto\tO\nbe\tO\na\tO\nsusceptibility\tO\nfactor\tO\nfor\tO\npsychotic\tB-Disease\ndisorders\tI-Disease\nsuch\tO\nas\tO\nschizophrenia\tB-Disease\n.\tO\n\nThe\tO\nserotonin\tB-Chemical\n6\tO\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHT6\tI-Chemical\n)\tO\nreceptor\tO\nis\tO\ntherapeutically\tO\ntargeted\tO\nby\tO\nseveral\tO\nsecond\tO\ngeneration\tO\nantipsychotics\tO\n,\tO\nsuch\tO\nas\tO\nclozapine\tB-Chemical\nand\tO\nolanzapine\tB-Chemical\n,\tO\nand\tO\nd\tB-Chemical\n-\tI-Chemical\namphetamine\tI-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nin\tO\nrats\tO\nis\tO\ncorrected\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\na\tO\nselective\tO\n5\tB-Chemical\n-\tI-Chemical\nHT6\tI-Chemical\nreceptor\tO\nantagonist\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthe\tO\ndisrupted\tO\nprepulse\tO\ninhibition\tO\ninduced\tO\nby\tO\nd\tB-Chemical\n-\tI-Chemical\namphetamine\tI-Chemical\nor\tO\nphencyclidine\tB-Chemical\nwas\tO\nrestored\tO\nby\tO\n5\tB-Chemical\n-\tI-Chemical\nHT6\tI-Chemical\nreceptor\tO\nantagonist\tO\nin\tO\nan\tO\nanimal\tO\nstudy\tO\nusing\tO\nrats\tO\n.\tO\n\nThese\tO\nanimal\tO\nmodels\tO\nwere\tO\nconsidered\tO\nto\tO\nreflect\tO\nthe\tO\npositive\tO\nsymptoms\tO\nof\tO\nschizophrenia\tB-Disease\n,\tO\nand\tO\nthe\tO\nabove\tO\nevidence\tO\nsuggests\tO\nthat\tO\naltered\tO\n5\tB-Chemical\n-\tI-Chemical\nHT6\tI-Chemical\nreceptors\tO\nare\tO\ninvolved\tO\nin\tO\nthe\tO\npathophysiology\tO\nof\tO\npsychotic\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nThe\tO\nsymptoms\tO\nof\tO\nmethamphetamine\tB-Chemical\n(\tO\nMETH\tB-Chemical\n)\tO\n-\tO\ninduced\tO\npsychosis\tB-Disease\nare\tO\nsimilar\tO\nto\tO\nthose\tO\nof\tO\nparanoid\tB-Disease\ntype\tI-Disease\nschizophrenia\tI-Disease\n.\tO\n\nTherefore\tO\n,\tO\nwe\tO\nconducted\tO\nan\tO\nanalysis\tO\nof\tO\nthe\tO\nassociation\tO\nof\tO\nthe\tO\n5\tB-Chemical\n-\tI-Chemical\nHT6\tI-Chemical\ngene\tO\n(\tO\nHTR6\tO\n)\tO\nwith\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nUsing\tO\nfive\tO\ntagging\tO\nSNPs\tO\n(\tO\nrs6693503\tO\n,\tO\nrs1805054\tO\n,\tO\nrs4912138\tO\n,\tO\nrs3790757\tO\nand\tO\nrs9659997\tO\n)\tO\n,\tO\nwe\tO\nconducted\tO\na\tO\ngenetic\tO\nassociation\tO\nanalysis\tO\nof\tO\ncase\tO\n-\tO\ncontrol\tO\nsamples\tO\n(\tO\n197\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\npatients\tO\nand\tO\n337\tO\ncontrols\tO\n)\tO\nin\tO\nthe\tO\nJapanese\tO\npopulation\tO\n.\tO\n\nThe\tO\nage\tO\nand\tO\nsex\tO\nof\tO\nthe\tO\ncontrol\tO\nsubjects\tO\ndid\tO\nnot\tO\ndiffer\tO\nfrom\tO\nthose\tO\nof\tO\nthe\tO\nmethamphetamine\tB-Chemical\ndependence\tO\npatients\tO\n.\tO\n\nRESULTS\tO\n:\tO\nrs6693503\tO\nwas\tO\nassociated\tO\nwith\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\npatients\tO\nin\tO\nthe\tO\nallele\tO\n/\tO\ngenotype\tO\n-\tO\nwise\tO\nanalysis\tO\n.\tO\n\nMoreover\tO\n,\tO\nthis\tO\nassociation\tO\nremained\tO\nsignificant\tO\nafter\tO\nBonferroni\tO\ncorrection\tO\n.\tO\n\nIn\tO\nthe\tO\nhaplotype\tO\n-\tO\nwise\tO\nanalysis\tO\n,\tO\nwe\tO\ndetected\tO\nan\tO\nassociation\tO\nbetween\tO\ntwo\tO\nmarkers\tO\n(\tO\nrs6693503\tO\nand\tO\nrs1805054\tO\n)\tO\nand\tO\nthree\tO\nmarkers\tO\n(\tO\nrs6693503\tO\n,\tO\nrs1805054\tO\nand\tO\nrs4912138\tO\n)\tO\nin\tO\nHTR6\tO\nand\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\npatients\tO\n,\tO\nrespectively\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nHTR6\tO\nmay\tO\nplay\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\npathophysiology\tO\nof\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\nin\tO\nthe\tO\nJapanese\tO\npopulation\tO\n.\tO\n\nNeural\tO\ncorrelates\tO\nof\tO\nS\tB-Chemical\n-\tI-Chemical\nketamine\tI-Chemical\ninduced\tO\npsychosis\tB-Disease\nduring\tO\novert\tO\ncontinuous\tO\nverbal\tO\nfluency\tO\n.\tO\n\nThe\tO\nglutamatergic\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nreceptor\tO\nhas\tO\nbeen\tO\nimplicated\tO\nin\tO\nthe\tO\npathophysiology\tO\nof\tO\nschizophrenia\tB-Disease\n.\tO\n\nAdministered\tO\nto\tO\nhealthy\tO\nvolunteers\tO\n,\tO\na\tO\nsubanesthetic\tO\ndose\tO\nof\tO\nthe\tO\nnon\tO\n-\tO\ncompetitive\tO\nNMDA\tB-Chemical\nreceptor\tO\nantagonist\tO\nketamine\tB-Chemical\nleads\tO\nto\tO\npsychopathological\tO\nsymptoms\tO\nsimilar\tO\nto\tO\nthose\tO\nobserved\tO\nin\tO\nschizophrenia\tB-Disease\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\nschizophrenia\tB-Disease\n,\tO\nketamine\tB-Chemical\nexacerbates\tO\nthe\tO\ncore\tO\nsymptoms\tO\nof\tO\nillness\tO\n,\tO\nsupporting\tO\nthe\tO\nhypothesis\tO\nof\tO\na\tO\nglutamatergic\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nIn\tO\na\tO\ncounterbalanced\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\ndesign\tO\n,\tO\nhealthy\tO\nsubjects\tO\nwere\tO\nadministered\tO\na\tO\ncontinuous\tO\nsubanesthetic\tO\nS\tB-Chemical\n-\tI-Chemical\nketamine\tI-Chemical\ninfusion\tO\nwhile\tO\ndifferences\tO\nin\tO\nBOLD\tO\nresponses\tO\nmeasured\tO\nwith\tO\nfMRI\tO\nwere\tO\ndetected\tO\n.\tO\n\nDuring\tO\nthe\tO\nscanning\tO\nperiod\tO\n,\tO\nsubjects\tO\nperformed\tO\ncontinuous\tO\novert\tO\nverbal\tO\nfluency\tO\ntasks\tO\n(\tO\nphonological\tO\n,\tO\nlexical\tO\nand\tO\nsemantic\tO\n)\tO\n.\tO\n\nKetamine\tB-Chemical\n-\tO\ninduced\tO\npsychopathological\tO\nsymptoms\tO\nwere\tO\nassessed\tO\nwith\tO\nthe\tO\nPositive\tO\nand\tO\nNegative\tO\nSyndrome\tO\nScale\tO\n(\tO\nPANSS\tO\n)\tO\n.\tO\n\nKetamine\tB-Chemical\nelicited\tO\npsychosis\tB-Disease\nlike\tO\npsychopathology\tO\n.\tO\n\nPost\tO\n-\tO\nhoc\tO\nt\tO\n-\tO\ntests\tO\nrevealed\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\nplacebo\tO\nand\tO\nketamine\tB-Chemical\nfor\tO\nthe\tO\namounts\tO\nof\tO\nwords\tO\ngenerated\tO\nduring\tO\nlexical\tO\nand\tO\nsemantic\tO\nverbal\tO\nfluency\tO\n,\tO\nwhile\tO\nthe\tO\nphonological\tO\ndomain\tO\nremained\tO\nunaffected\tO\n.\tO\n\nKetamine\tB-Chemical\nled\tO\nto\tO\nenhanced\tO\ncortical\tO\nactivations\tO\nin\tO\nsupramarginal\tO\nand\tO\nfrontal\tO\nbrain\tO\nregions\tO\nfor\tO\nphonological\tO\nand\tO\nlexical\tO\nverbal\tO\nfluency\tO\n,\tO\nbut\tO\nnot\tO\nfor\tO\nsemantic\tO\nverbal\tO\nfluency\tO\n.\tO\n\nKetamine\tB-Chemical\ninduces\tO\nactivation\tO\nchanges\tO\nin\tO\nhealthy\tO\nsubjects\tO\nsimilar\tO\nto\tO\nthose\tO\nobserved\tO\nin\tO\npatients\tO\nwith\tO\nschizophrenia\tB-Disease\n,\tO\nparticularly\tO\nin\tO\nfrontal\tO\nand\tO\ntemporal\tO\nbrain\tO\nregions\tO\n.\tO\n\nOur\tO\nresults\tO\nprovide\tO\nfurther\tO\nsupport\tO\nfor\tO\nthe\tO\nhypothesis\tO\nof\tO\nan\tO\nNMDA\tB-Chemical\nreceptor\tO\ndysfunction\tO\nin\tO\nthe\tO\npathophysiology\tO\nof\tO\nschizophrenia\tB-Disease\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nprognosis\tO\nfor\tO\ntransplant\tO\n-\tO\nfree\tO\nsurvivors\tO\nof\tO\nparacetamol\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nprognosis\tO\nfor\tO\ntransplant\tO\n-\tO\nfree\tO\nsurvivors\tO\nof\tO\nparacetamol\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nremains\tO\nunknown\tO\n.\tO\n\nAIM\tO\n:\tO\nTo\tO\nexamine\tO\nwhether\tO\nparacetamol\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nincreases\tO\nlong\tO\n-\tO\nterm\tO\nmortality\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nfollowed\tO\nup\tO\nall\tO\ntransplant\tO\n-\tO\nfree\tO\nsurvivors\tO\nof\tO\nparacetamol\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nliver\tI-Disease\ninjury\tI-Disease\n,\tO\nhospitalized\tO\nin\tO\na\tO\nDanish\tO\nnational\tO\nreferral\tO\ncentre\tO\nduring\tO\n1984\tO\n-\tO\n2004\tO\n.\tO\n\nWe\tO\ncompared\tO\nage\tO\n-\tO\nspecific\tO\nmortality\tO\nrates\tO\nfrom\tO\n1\tO\nyear\tO\npost\tO\n-\tO\ndischarge\tO\nthrough\tO\n2008\tO\nbetween\tO\nthose\tO\nin\tO\nwhom\tO\nthe\tO\nliver\tB-Disease\ninjury\tI-Disease\nled\tO\nto\tO\nan\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nand\tO\nthose\tO\nin\tO\nwhom\tO\nit\tO\ndid\tO\nnot\tO\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nincluded\tO\n641\tO\npatients\tO\n.\tO\n\nOn\tO\naverage\tO\n,\tO\nage\tO\n-\tO\nspecific\tO\nmortality\tO\nrates\tO\nwere\tO\nslightly\tO\nhigher\tO\nfor\tO\nthe\tO\n101\tO\npatients\tO\nwhose\tO\nparacetamol\tB-Chemical\n-\tO\ninduced\tO\nliver\tB-Disease\ninjury\tI-Disease\nhad\tO\ncaused\tO\nan\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n(\tO\nadjusted\tO\nmortality\tO\nrate\tO\nratio\tO\n=\tO\n1\tO\n.\tO\n70\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n02\tO\n-\tO\n2\tO\n.\tO\n85\tO\n)\tO\n,\tO\nbut\tO\nthe\tO\nassociation\tO\nwas\tO\nage\tO\n-\tO\ndependent\tO\n,\tO\nand\tO\nno\tO\nsurvivors\tO\nof\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\ndied\tO\nof\tO\nliver\tB-Disease\ndisease\tI-Disease\n,\tO\nwhereas\tO\nsuicides\tO\nwere\tO\nfrequent\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nThese\tO\nobservations\tO\nspeak\tO\nagainst\tO\nlong\tO\n-\tO\nterm\tO\neffects\tO\nof\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n.\tO\n\nMore\tO\nlikely\tO\n,\tO\nthe\tO\nelevated\tO\nmortality\tO\nrate\tO\nratio\tO\nresulted\tO\nfrom\tO\nincomplete\tO\nadjustment\tO\nfor\tO\nthe\tO\ngreater\tO\nprevalence\tO\nof\tO\nsubstance\tB-Disease\nabuse\tI-Disease\namong\tO\nsurvivors\tO\nof\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nParacetamol\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\ndid\tO\nnot\tO\naffect\tO\nlong\tO\n-\tO\nterm\tO\nmortality\tO\n.\tO\n\nClinical\tO\nfollow\tO\n-\tO\nup\tO\nmay\tO\nbe\tO\njustified\tO\nby\tO\nthe\tO\ncause\tO\nof\tO\nthe\tO\nliver\tB-Disease\nfailure\tI-Disease\n,\tO\nbut\tO\nnot\tO\nby\tO\nthe\tO\nliver\tB-Disease\nfailure\tI-Disease\nitself\tO\n.\tO\n\nIn\tO\nvivo\tO\ncharacterization\tO\nof\tO\na\tO\ndual\tO\nadenosine\tB-Chemical\nA2A\tI-Chemical\n/\tI-Chemical\nA1\tI-Chemical\nreceptor\tI-Chemical\nantagonist\tI-Chemical\nin\tO\nanimal\tO\nmodels\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nThe\tO\nin\tO\nvivo\tO\ncharacterization\tO\nof\tO\na\tO\ndual\tO\nadenosine\tB-Chemical\nA\tI-Chemical\n(\tI-Chemical\n2A\tI-Chemical\n)\tI-Chemical\n/\tI-Chemical\nA\tI-Chemical\n(\tI-Chemical\n1\tI-Chemical\n)\tI-Chemical\nreceptor\tI-Chemical\nantagonist\tI-Chemical\nin\tO\nseveral\tO\nanimal\tO\nmodels\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nis\tO\ndescribed\tO\n.\tO\n\nDiscovery\tO\nand\tO\nscale\tO\n-\tO\nup\tO\nsyntheses\tO\nof\tO\ncompound\tO\n1\tO\nare\tO\ndescribed\tO\nin\tO\ndetail\tO\n,\tO\nhighlighting\tO\noptimization\tO\nsteps\tO\nthat\tO\nincreased\tO\nthe\tO\noverall\tO\nyield\tO\nof\tO\n1\tO\nfrom\tO\n10\tO\n.\tO\n0\tO\n%\tO\nto\tO\n30\tO\n.\tO\n5\tO\n%\tO\n.\tO\n\nCompound\tO\n1\tO\nis\tO\na\tO\npotent\tO\nA\tO\n(\tO\n2A\tO\n)\tO\n/\tO\nA\tO\n(\tO\n1\tO\n)\tO\nreceptor\tO\nantagonist\tO\nin\tO\nvitro\tO\n(\tO\nA\tO\n(\tO\n2A\tO\n)\tO\nK\tO\n(\tO\ni\tO\n)\tO\n=\tO\n4\tO\n.\tO\n1\tO\nnM\tO\n;\tO\nA\tO\n(\tO\n1\tO\n)\tO\nK\tO\n(\tO\ni\tO\n)\tO\n=\tO\n17\tO\n.\tO\n0\tO\nnM\tO\n)\tO\nthat\tO\nhas\tO\nexcellent\tO\nactivity\tO\n,\tO\nafter\tO\noral\tO\nadministration\tO\n,\tO\nacross\tO\na\tO\nnumber\tO\nof\tO\nanimal\tO\nmodels\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nincluding\tO\nmouse\tO\nand\tO\nrat\tO\nmodels\tO\nof\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n,\tO\nmouse\tO\nmodel\tO\nof\tO\nreserpine\tB-Chemical\n-\tO\ninduced\tO\nakinesia\tB-Disease\n,\tO\nrat\tO\n6\tB-Chemical\n-\tI-Chemical\nhydroxydopamine\tI-Chemical\n(\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\n)\tO\nlesion\tO\nmodel\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nrotation\tO\n,\tO\nand\tO\nMPTP\tB-Chemical\n-\tO\ntreated\tO\nnon\tO\n-\tO\nhuman\tO\nprimate\tO\nmodel\tO\n.\tO\n\nEffects\tO\nof\tO\nthe\tO\nhippocampal\tO\ndeep\tO\nbrain\tO\nstimulation\tO\non\tO\ncortical\tO\nepileptic\tB-Disease\ndischarges\tO\nin\tO\npenicillin\tB-Chemical\n-\tO\ninduced\tO\nepilepsy\tB-Disease\nmodel\tO\nin\tO\nrats\tO\n.\tO\n\nAIM\tO\n:\tO\nExperimental\tO\nand\tO\nclinical\tO\nstudies\tO\nhave\tO\nrevealed\tO\nthat\tO\nhippocampal\tO\nDBS\tO\ncan\tO\ncontrol\tO\nepileptic\tB-Disease\nactivity\tO\n,\tO\nbut\tO\nthe\tO\nmechanism\tO\nof\tO\naction\tO\nis\tO\nobscure\tO\nand\tO\noptimal\tO\nstimulation\tO\nparameters\tO\nare\tO\nnot\tO\nclearly\tO\ndefined\tO\n.\tO\n\nThe\tO\naim\tO\nwas\tO\nto\tO\nevaluate\tO\nthe\tO\neffects\tO\nof\tO\nhigh\tO\nfrequency\tO\nhippocampal\tO\nstimulation\tO\non\tO\ncortical\tO\nepileptic\tB-Disease\nactivity\tO\nin\tO\npenicillin\tB-Chemical\n-\tO\ninduced\tO\nepilepsy\tB-Disease\nmodel\tO\n.\tO\n\nMATERIAL\tO\nAND\tO\nMETHODS\tO\n:\tO\nTwenty\tO\n-\tO\nfive\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\nimplanted\tO\nDBS\tO\nelectrodes\tO\n.\tO\n\nIn\tO\ngroup\tO\n-\tO\n1\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\nhippocampal\tO\nDBS\tO\nwas\tO\noff\tO\nand\tO\nin\tO\nthe\tO\ngroup\tO\n-\tO\n2\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\nhippocampal\tO\nDBS\tO\nwas\tO\non\tO\n(\tO\n185\tO\nHz\tO\n,\tO\n0\tO\n.\tO\n5V\tO\n,\tO\n1V\tO\n,\tO\n2V\tO\n,\tO\nand\tO\n5V\tO\nfor\tO\n60\tO\nsec\tO\n)\tO\nfollowing\tO\npenicillin\tB-Chemical\nG\tI-Chemical\ninjection\tO\nintracortically\tO\n.\tO\n\nIn\tO\nthe\tO\ncontrol\tO\ngroup\tO\nhippocampal\tO\nDBS\tO\nwas\tO\non\tO\nfollowing\tO\n8\tO\nl\tO\nsaline\tO\ninjection\tO\nintracortically\tO\n.\tO\n\nEEG\tO\nrecordings\tO\nwere\tO\nobtained\tO\nbefore\tO\nand\tO\n15\tO\nminutes\tO\nfollowing\tO\npenicillin\tB-Chemical\n-\tI-Chemical\nG\tI-Chemical\ninjection\tO\n,\tO\nand\tO\nat\tO\n10th\tO\nminutes\tO\nfollowing\tO\neach\tO\nstimulus\tO\nfor\tO\nanalysis\tO\nin\tO\nterms\tO\nof\tO\nfrequency\tO\n,\tO\namplitude\tO\n,\tO\nand\tO\npower\tO\nspectrum\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHigh\tO\nfrequency\tO\nhippocampal\tO\nDBS\tO\nsuppressed\tO\nthe\tO\nacute\tO\npenicillin\tB-Chemical\n-\tO\ninduced\tO\ncortical\tO\nepileptic\tB-Disease\nactivity\tO\nindependent\tO\nfrom\tO\nstimulus\tO\nintensity\tO\n.\tO\n\nIn\tO\nthe\tO\ncontrol\tO\ngroup\tO\n,\tO\nhippocampal\tO\nstimulation\tO\nalone\tO\nlead\tO\nonly\tO\nto\tO\ndiffuse\tO\nslowing\tO\nof\tO\ncerebral\tO\nbioelectrical\tO\nactivity\tO\nat\tO\n5V\tO\nstimulation\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\nresults\tO\nrevealed\tO\nthat\tO\ncontinuous\tO\nhigh\tO\nfrequency\tO\nstimulation\tO\nof\tO\nthe\tO\nhippocampus\tO\nsuppressed\tO\nacute\tO\ncortical\tO\nepileptic\tB-Disease\nactivity\tO\neffectively\tO\nwithout\tO\ncausing\tO\nsecondary\tO\nepileptic\tB-Disease\ndischarges\tO\n.\tO\n\nThese\tO\nresults\tO\nare\tO\nimportant\tO\nin\tO\nterms\tO\nof\tO\ndefining\tO\nthe\tO\noptimal\tO\nparameters\tO\nof\tO\nhippocampal\tO\nDBS\tO\nin\tO\npatients\tO\nwith\tO\nepilepsy\tB-Disease\n.\tO\n\nCCNU\tB-Chemical\n(\tO\nlomustine\tB-Chemical\n)\tO\ntoxicity\tB-Disease\nin\tO\ndogs\tO\n:\tO\na\tO\nretrospective\tO\nstudy\tO\n(\tO\n2002\tO\n-\tO\n07\tO\n)\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\nthe\tO\nincidence\tO\nof\tO\nhaematological\tB-Disease\n,\tI-Disease\nrenal\tI-Disease\n,\tI-Disease\nhepatic\tI-Disease\nand\tI-Disease\ngastrointestinal\tI-Disease\ntoxicities\tI-Disease\nin\tO\ntumour\tO\n-\tO\nbearing\tO\ndogs\tO\nreceiving\tO\n1\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nchloroethyl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\ncyclohexyl\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nnitrosourea\tI-Chemical\n(\tO\nCCNU\tB-Chemical\n)\tO\n.\tO\n\nDESIGN\tO\n:\tO\nThe\tO\nmedical\tO\nrecords\tO\nof\tO\n206\tO\ndogs\tO\nthat\tO\nwere\tO\ntreated\tO\nwith\tO\nCCNU\tB-Chemical\nat\tO\nthe\tO\nMelbourne\tO\nVeterinary\tO\nSpecialist\tO\nCentre\tO\nbetween\tO\nFebruary\tO\n2002\tO\nand\tO\nDecember\tO\n2007\tO\nwere\tO\nretrospectively\tO\nevaluated\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOf\tO\nthe\tO\n206\tO\ndogs\tO\ntreated\tO\nwith\tO\nCCNU\tB-Chemical\n,\tO\n185\tO\nmet\tO\nthe\tO\ninclusion\tO\ncriteria\tO\nfor\tO\nat\tO\nleast\tO\none\tO\nclass\tO\nof\tO\ntoxicity\tB-Disease\n.\tO\n\nCCNU\tB-Chemical\nwas\tO\nused\tO\nmost\tO\ncommonly\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nlymphoma\tB-Disease\n,\tO\nmast\tB-Disease\ncell\tI-Disease\ntumour\tI-Disease\n,\tO\nbrain\tB-Disease\ntumour\tI-Disease\n,\tO\nhistiocytic\tB-Disease\ntumours\tI-Disease\nand\tO\nepitheliotropic\tB-Disease\nlymphoma\tI-Disease\n.\tO\n\nThroughout\tO\ntreatment\tO\n,\tO\n56\tO\n.\tO\n9\tO\n%\tO\nof\tO\ndogs\tO\nexperienced\tO\nneutropenia\tB-Disease\n,\tO\n34\tO\n.\tO\n2\tO\n%\tO\nexperienced\tO\nanaemia\tB-Disease\nand\tO\n14\tO\n.\tO\n2\tO\n%\tO\nexperienced\tO\nthrombocytopenia\tB-Disease\n.\tO\n\nGastrointestinal\tB-Disease\ntoxicosis\tI-Disease\nwas\tO\ndetected\tO\nin\tO\n37\tO\n.\tO\n8\tO\n%\tO\nof\tO\ndogs\tO\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nsign\tO\nof\tO\nwhich\tO\nwas\tO\nvomiting\tB-Disease\n(\tO\n24\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nPotential\tO\nrenal\tO\ntoxicity\tB-Disease\nand\tO\nelevated\tO\nalanine\tB-Chemical\ntransaminase\tO\n(\tO\nALT\tO\n)\tO\nconcentration\tO\nwere\tO\nreported\tO\nin\tO\n12\tO\n.\tO\n2\tO\n%\tO\nand\tO\n48\tO\n.\tO\n8\tO\n%\tO\nof\tO\ndogs\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nhepatic\tB-Disease\nfailure\tI-Disease\nwas\tO\n1\tO\n.\tO\n2\tO\n%\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCCNU\tB-Chemical\n-\tO\nassociated\tO\ntoxicity\tB-Disease\nin\tO\ndogs\tO\nis\tO\ncommon\tO\n,\tO\nbut\tO\nis\tO\nusually\tO\nnot\tO\nlife\tO\nthreatening\tO\n.\tO\n\nCentral\tO\nvein\tB-Disease\nthrombosis\tI-Disease\nand\tO\ntopical\tO\ndipivalyl\tB-Chemical\nepinephrine\tI-Chemical\n.\tO\n\nA\tO\nreport\tO\nis\tO\ngiven\tO\non\tO\nan\tO\n83\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfemale\tO\nwho\tO\nacquired\tO\ncentral\tO\nvein\tB-Disease\nthrombosis\tI-Disease\nin\tO\nher\tO\nseeing\tO\neye\tO\none\tO\nday\tO\nafter\tO\nhaving\tO\nstarted\tO\ntopical\tO\nmedication\tO\nwith\tO\ndipivalyl\tB-Chemical\nepinephrine\tI-Chemical\nfor\tO\nadvanced\tO\nglaucoma\tB-Disease\ndiscovered\tO\nin\tO\nthe\tO\nother\tO\neye\tO\n.\tO\n\nFrom\tO\npresent\tO\nknowledge\tO\nabout\tO\nthe\tO\neffects\tO\nof\tO\nadrenergic\tO\neye\tO\ndrops\tO\non\tO\nocular\tO\nblood\tO\ncirculation\tO\n,\tO\nit\tO\nis\tO\ndifficult\tO\nto\tO\nsuggest\tO\nan\tO\nassociation\tO\nbetween\tO\nthe\tO\ntwo\tO\nevents\tO\n,\tO\nwhich\tO\nmay\tO\nbe\tO\ncoincidental\tO\nonly\tO\n.\tO\n\nBenzylacyclouridine\tB-Chemical\nreverses\tO\nazidothymidine\tB-Chemical\n-\tO\ninduced\tO\nmarrow\tB-Disease\nsuppression\tI-Disease\nwithout\tO\nimpairment\tO\nof\tO\nanti\tO\n-\tO\nhuman\tO\nimmunodeficiency\tB-Disease\nvirus\tO\nactivity\tO\n.\tO\n\nIncreased\tO\nextracellular\tO\nconcentrations\tO\nof\tO\nuridine\tB-Chemical\n(\tO\nUrd\tB-Chemical\n)\tO\nhave\tO\nbeen\tO\nreported\tO\nto\tO\nreduce\tO\n,\tO\nin\tO\nvitro\tO\n,\tO\nazidothymidine\tB-Chemical\n(\tO\nAZT\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ninhibition\tO\nof\tO\nhuman\tO\ngranulocyte\tO\n-\tO\nmacrophage\tO\nprogenitor\tO\ncells\tO\nwithout\tO\nimpairment\tO\nof\tO\nits\tO\nantihuman\tO\nimmunodeficiency\tB-Disease\nvirus\tO\n(\tO\nHIV\tO\n)\tO\nactivity\tO\n.\tO\n\nBecause\tO\nof\tO\nthe\tO\nclinical\tO\ntoxicities\tB-Disease\nassociated\tO\nwith\tO\nchronic\tO\nUrd\tB-Chemical\nadministration\tO\n,\tO\nthe\tO\nability\tO\nof\tO\nbenzylacyclouridine\tB-Chemical\n(\tO\nBAU\tB-Chemical\n)\tO\nto\tO\neffect\tO\n,\tO\nin\tO\nvivo\tO\n,\tO\nAZT\tB-Chemical\n-\tO\ninduced\tO\nanemia\tB-Disease\nand\tO\nleukopenia\tB-Disease\nwas\tO\nassessed\tO\n.\tO\n\nThis\tO\nagent\tO\ninhibits\tO\nUrd\tB-Chemical\ncatabolism\tO\nand\tO\n,\tO\nin\tO\nvivo\tO\n,\tO\nincreases\tO\nthe\tO\nplasma\tO\nconcentration\tO\nof\tO\nUrd\tB-Chemical\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n,\tO\nwithout\tO\nUrd\tB-Chemical\n-\tO\nrelated\tO\ntoxicity\tB-Disease\n.\tO\n\nIn\tO\nmice\tO\nrendered\tO\nanemic\tB-Disease\nand\tO\nleukopenic\tB-Disease\nby\tO\nthe\tO\nadministration\tO\nof\tO\nAZT\tB-Chemical\nfor\tO\n28\tO\ndays\tO\nin\tO\ndrinking\tO\nwater\tO\n(\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nmL\tO\n)\tO\n,\tO\nthe\tO\ncontinued\tO\nadministration\tO\nof\tO\nAZT\tB-Chemical\nplus\tO\ndaily\tO\nBAU\tB-Chemical\n(\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\norally\tO\n)\tO\npartially\tO\nreversed\tO\nAZT\tB-Chemical\n-\tO\ninduced\tO\nanemia\tB-Disease\nand\tO\nleukopenia\tB-Disease\n(\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n05\tO\n)\tO\n,\tO\nincreased\tO\nperipheral\tO\nreticulocytes\tO\n(\tO\nto\tO\n4\tO\n.\tO\n9\tO\n%\tO\n,\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n01\tO\n)\tO\n,\tO\nincreased\tO\ncellularity\tO\nin\tO\nthe\tO\nmarrow\tO\n,\tO\nand\tO\nimproved\tO\nmegaloblastosis\tB-Disease\n.\tO\n\nWhen\tO\ncoadministered\tO\nwith\tO\nAZT\tB-Chemical\nfrom\tO\nthe\tO\nonset\tO\nof\tO\ndrug\tO\nadministration\tO\n,\tO\nBAU\tB-Chemical\nreduced\tO\nAZT\tB-Chemical\n-\tO\ninduced\tO\nmarrow\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nIn\tO\nvitro\tO\n,\tO\nat\tO\na\tO\nconcentration\tO\nof\tO\n100\tO\nmumol\tO\n/\tO\nL\tO\n,\tO\nBAU\tB-Chemical\npossesses\tO\nminimal\tO\nanti\tO\n-\tO\nHIV\tO\nactivity\tO\nand\tO\nhas\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nability\tO\nof\tO\nAZT\tB-Chemical\nto\tO\nreverse\tO\nthe\tO\nHIV\tO\n-\tO\ninduced\tO\ncytopathic\tO\neffect\tO\nin\tO\nMT4\tO\ncells\tO\n.\tO\n\nThe\tO\nclinical\tO\nand\tO\nbiochemical\tO\nimplications\tO\nof\tO\nthese\tO\nfindings\tO\nare\tO\ndiscussed\tO\n.\tO\n\nLethal\tO\nanuria\tB-Disease\ncomplicating\tO\nhigh\tO\ndose\tO\nifosfamide\tB-Chemical\nchemotherapy\tO\nin\tO\na\tO\nbreast\tB-Disease\ncancer\tI-Disease\npatient\tO\nwith\tO\nan\tO\nimpaired\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\n.\tO\n\nA\tO\nsixty\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nadvanced\tO\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\npreviously\tO\ntreated\tO\nwith\tO\ncisplatin\tB-Chemical\n,\tO\ndeveloped\tO\nan\tO\nirreversible\tO\nlethal\tO\nrenal\tB-Disease\nfailure\tI-Disease\nwith\tO\nanuria\tB-Disease\n,\tO\nthe\tO\nday\tO\nafter\tO\n5\tO\ng\tO\n/\tO\nm2\tO\nbolus\tO\nifosfamide\tB-Chemical\n.\tO\n\nPostrenal\tB-Disease\nfailure\tI-Disease\nwas\tO\nexcluded\tO\nby\tO\nechography\tO\n.\tO\n\nA\tO\nprerenal\tO\ncomponent\tO\ncould\tO\nhave\tO\ncontributed\tO\nto\tO\nrenal\tB-Disease\nfailure\tI-Disease\nbecause\tO\nof\tO\na\tO\ntransient\tO\nhypotension\tB-Disease\n,\tO\ndue\tO\nto\tO\nan\tO\nincreasing\tO\nascitis\tO\n,\tO\noccurring\tO\njust\tO\nbefore\tO\nanuria\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\ncorrection\tO\nof\tO\nthe\tO\nhemodynamic\tO\nparameters\tO\ndid\tO\nnot\tO\nimprove\tO\nrenal\tO\nfunction\tO\n.\tO\n\nIfosfamide\tB-Chemical\nis\tO\na\tO\nknown\tO\nnephrotoxic\tB-Disease\ndrug\tO\nwith\tO\ndemonstrated\tO\ntubulopathies\tB-Disease\n.\tO\n\nWe\tO\nstrongly\tO\nsuspect\tO\nthat\tO\nthis\tO\nlethal\tO\nanuria\tB-Disease\nwas\tO\nmainly\tO\ndue\tO\nto\tO\nifosfamide\tB-Chemical\n,\tO\noccurring\tO\nin\tO\na\tO\npatient\tO\nhaving\tO\nreceived\tO\nprevious\tO\ncisplatin\tB-Chemical\nchemotherapy\tO\nand\tO\nwith\tO\npoor\tO\nkidney\tO\nperfusion\tO\ndue\tO\nto\tO\ntransient\tO\nhypotension\tB-Disease\n.\tO\n\nWe\tO\nrecommend\tO\ncareful\tO\nuse\tO\nof\tO\nifosfamide\tB-Chemical\nin\tO\npatients\tO\npretreated\tO\nwith\tO\nnephrotoxic\tB-Disease\nchemotherapy\tO\nand\tO\ninadequate\tO\nrenal\tO\nperfusion\tO\n.\tO\n\nNociceptive\tO\neffects\tO\ninduced\tO\nby\tO\nintrathecal\tO\nadministration\tO\nof\tO\nprostaglandin\tB-Chemical\nD2\tI-Chemical\n,\tI-Chemical\nE2\tI-Chemical\n,\tI-Chemical\nor\tI-Chemical\nF2\tI-Chemical\nalpha\tI-Chemical\nto\tO\nconscious\tO\nmice\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nintrathecal\tO\nadministration\tO\nof\tO\nprostaglandins\tB-Chemical\non\tO\npain\tB-Disease\nresponses\tO\nin\tO\nconscious\tO\nmice\tO\nwere\tO\nevaluated\tO\nby\tO\nusing\tO\nhot\tO\nplate\tO\nand\tO\nacetic\tB-Chemical\nacid\tI-Chemical\nwrithing\tO\ntests\tO\n.\tO\n\nProstaglandin\tB-Chemical\nD2\tI-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\n-\tO\n3\tO\nng\tO\n/\tO\nmouse\tO\n)\tO\nhad\tO\na\tO\nhyperalgesic\tB-Disease\naction\tO\non\tO\nthe\tO\nresponse\tO\nto\tO\na\tO\nhot\tO\nplate\tO\nduring\tO\na\tO\n3\tO\n-\tO\n60\tO\nmin\tO\nperiod\tO\nafter\tO\ninjection\tO\n.\tO\n\nProstaglandin\tB-Chemical\nE2\tI-Chemical\nshowed\tO\na\tO\nhyperalgesic\tB-Disease\neffect\tO\nat\tO\ndoses\tO\nof\tO\n1\tO\npg\tB-Chemical\nto\tO\n10\tO\nng\tO\n/\tO\nmouse\tO\n,\tO\nbut\tO\nthe\tO\neffect\tO\nlasted\tO\nshorter\tO\n(\tO\n3\tO\n-\tO\n30\tO\nmin\tO\n)\tO\nthan\tO\nthat\tO\nof\tO\nprostaglandin\tB-Chemical\nD2\tI-Chemical\n.\tO\n\nSimilar\tO\nresults\tO\nwere\tO\nobtained\tO\nby\tO\nacetic\tB-Chemical\nacid\tI-Chemical\nwrithing\tO\ntests\tO\n.\tO\n\nThe\tO\nhyperalgesic\tB-Disease\neffect\tO\nof\tO\nprostaglandin\tB-Chemical\nD2\tI-Chemical\nwas\tO\nblocked\tO\nby\tO\nsimultaneous\tO\ninjection\tO\nof\tO\na\tO\nsubstance\tO\nP\tO\nantagonist\tO\n(\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n100\tO\nng\tO\n)\tO\nbut\tO\nnot\tO\nby\tO\nAH6809\tB-Chemical\n,\tO\na\tO\nprostanoid\tO\nEP1\tO\n-\tO\nreceptor\tO\nantagonist\tO\n.\tO\n\nConversely\tO\n,\tO\nprostaglandin\tB-Chemical\nE2\tI-Chemical\n-\tO\ninduced\tO\nhyperalgesia\tB-Disease\nwas\tO\nblocked\tO\nby\tO\nAH6809\tB-Chemical\n(\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n500\tO\nng\tO\n)\tO\nbut\tO\nnot\tO\nby\tO\nthe\tO\nsubstance\tO\nP\tO\nantagonist\tO\n.\tO\n\nProstaglandin\tB-Chemical\nF2\tI-Chemical\nalpha\tI-Chemical\nhad\tO\nlittle\tO\neffect\tO\non\tO\npain\tB-Disease\nresponses\tO\n.\tO\n\nThese\tO\nresults\tO\ndemonstrate\tO\nthat\tO\nboth\tO\nprostaglandin\tB-Chemical\nD2\tI-Chemical\nand\tO\nprostaglandin\tB-Chemical\nE2\tI-Chemical\nexert\tO\nhyperalgesia\tB-Disease\nin\tO\nthe\tO\nspinal\tO\ncord\tO\n,\tO\nbut\tO\nin\tO\ndifferent\tO\nways\tO\n.\tO\n\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nlocalized\tB-Disease\nscleroderma\tI-Disease\n.\tO\n\nLocalized\tB-Disease\nscleroderma\tI-Disease\nhas\tO\nno\tO\nrecognized\tO\ninternal\tO\norgan\tO\ninvolvement\tO\nbut\tO\nmay\tO\nbe\tO\ndisfiguring\tO\nand\tO\ndisabling\tO\nwhen\tO\nthe\tO\ncutaneous\tO\nlesions\tO\nare\tO\nextensive\tO\nor\tO\naffect\tO\nchildren\tO\n.\tO\n\nThere\tO\nis\tO\nno\tO\naccepted\tO\nor\tO\nproven\tO\ntreatment\tO\nfor\tO\nlocalized\tB-Disease\nscleroderma\tI-Disease\n.\tO\n\nCase\tO\nreports\tO\nof\tO\n11\tO\npatients\tO\nwith\tO\nsevere\tO\n,\tO\nextensive\tO\nlocalized\tB-Disease\nscleroderma\tI-Disease\nwho\tO\nwere\tO\ntreated\tO\nwith\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\nare\tO\nsummarized\tO\nin\tO\nthis\tO\narticle\tO\n.\tO\n\nThis\tO\ndrug\tO\nwas\tO\njudged\tO\nto\tO\nhave\tO\na\tO\nfavorable\tO\neffect\tO\non\tO\nthe\tO\ndisease\tO\ncourse\tO\nin\tO\n7\tO\n(\tO\n64\tO\n%\tO\n)\tO\nof\tO\n11\tO\npatients\tO\n.\tO\n\nImprovement\tO\nbegan\tO\nwithin\tO\n3\tO\nto\tO\n6\tO\nmonths\tO\nand\tO\nconsisted\tO\nof\tO\ncessation\tO\nof\tO\nactive\tO\ncutaneous\tO\nlesions\tO\nin\tO\nall\tO\n7\tO\npatients\tO\n,\tO\nskin\tO\nsoftening\tO\nin\tO\n5\tO\n,\tO\nand\tO\nmore\tO\nnormal\tO\ngrowth\tO\nof\tO\nthe\tO\naffected\tO\nlimb\tO\nin\tO\n2\tO\nof\tO\n3\tO\nchildren\tO\n.\tO\n\nJoint\tO\nstiffness\tO\nand\tO\ncontractures\tB-Disease\nalso\tO\nimproved\tO\n.\tO\n\nThe\tO\ndose\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\nassociated\tO\nwith\tO\na\tO\nfavorable\tO\nresponse\tO\nwas\tO\nas\tO\nlow\tO\nas\tO\n2\tO\nto\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\ngiven\tO\nover\tO\na\tO\nperiod\tO\nranging\tO\nfrom\tO\n15\tO\nto\tO\n53\tO\nmonths\tO\n.\tO\n\nD\tB-Chemical\n-\tI-Chemical\nPenicillamine\tI-Chemical\ncaused\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\nin\tO\n1\tO\npatient\tO\nand\tO\nmilder\tO\nreversible\tO\nproteinuria\tB-Disease\nin\tO\n3\tO\nother\tO\npatients\tO\n;\tO\nnone\tO\ndeveloped\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\nmay\tO\nbe\tO\neffective\tO\nin\tO\nsevere\tO\ncases\tO\nof\tO\nlocalized\tB-Disease\nscleroderma\tI-Disease\n.\tO\n\nCerebral\tB-Disease\nsinus\tI-Disease\nthrombosis\tI-Disease\nas\tO\na\tO\npotential\tO\nhazard\tO\nof\tO\nantifibrinolytic\tO\ntreatment\tO\nin\tO\nmenorrhagia\tB-Disease\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n42\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwho\tO\ndeveloped\tO\nsuperior\tO\nsagittal\tB-Disease\nand\tI-Disease\nleft\tI-Disease\ntransverse\tI-Disease\nsinus\tI-Disease\nthrombosis\tI-Disease\nassociated\tO\nwith\tO\nprolonged\tO\nepsilon\tB-Chemical\n-\tI-Chemical\naminocaproic\tI-Chemical\nacid\tI-Chemical\ntherapy\tO\nfor\tO\nmenorrhagia\tB-Disease\n.\tO\n\nThis\tO\nantifibrinolytic\tO\nagent\tO\nhas\tO\nbeen\tO\nused\tO\nin\tO\nwomen\tO\nwith\tO\nmenorrhagia\tB-Disease\nto\tO\npromote\tO\nclotting\tO\nand\tO\nreduce\tO\nblood\tB-Disease\nloss\tI-Disease\n.\tO\n\nAlthough\tO\nincreased\tO\nrisk\tO\nof\tO\nthromboembolic\tB-Disease\ndisease\tI-Disease\nhas\tO\nbeen\tO\nreported\tO\nduring\tO\ntreatment\tO\nwith\tO\nepsilon\tB-Chemical\n-\tI-Chemical\naminocaproic\tI-Chemical\nacid\tI-Chemical\n,\tO\ncerebral\tB-Disease\nsinus\tI-Disease\nthrombosis\tI-Disease\nhas\tO\nnot\tO\nbeen\tO\npreviously\tO\ndescribed\tO\n.\tO\n\nCareful\tO\nuse\tO\nof\tO\nepsilon\tB-Chemical\n-\tI-Chemical\naminocaproic\tI-Chemical\nacid\tI-Chemical\ntherapy\tO\nis\tO\nrecommended\tO\n.\tO\n\nSeizure\tB-Disease\nactivity\tO\nwith\tO\nimipenem\tB-Chemical\ntherapy\tO\n:\tO\nincidence\tO\nand\tO\nrisk\tO\nfactors\tO\n.\tO\n\nTwo\tO\nelderly\tO\npatients\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\neither\tO\ncerebral\tB-Disease\nvascular\tI-Disease\naccident\tI-Disease\n(\tO\nCVA\tB-Disease\n)\tO\nor\tO\nhead\tB-Disease\ntrauma\tI-Disease\nand\tO\nno\tO\nevidence\tO\nof\tO\nrenal\tB-Disease\ndisease\tI-Disease\ndeveloped\tO\nseizures\tB-Disease\nwhile\tO\nreceiving\tO\nmaximum\tO\ndoses\tO\nof\tO\nimipenem\tB-Chemical\n/\tI-Chemical\ncilastatin\tI-Chemical\n.\tO\n\nNeither\tO\npatient\tO\nhad\tO\nreported\tO\nprevious\tO\nseizures\tB-Disease\nor\tO\nseizure\tB-Disease\n-\tO\nlike\tO\nactivity\tO\nnor\tO\nwas\tO\nreceiving\tO\nanticonvulsant\tO\nagents\tO\n.\tO\n\nAll\tO\nseizures\tB-Disease\nwere\tO\ncontrolled\tO\nwith\tO\ntherapeutic\tO\ndoses\tO\nof\tO\nphenytoin\tB-Chemical\n.\tO\n\nBoth\tO\npatients\tO\nhad\tO\nreceived\tO\nmaximum\tO\ndoses\tO\nof\tO\nother\tO\nbeta\tB-Chemical\n-\tI-Chemical\nlactam\tI-Chemical\nantibiotics\tO\nwithout\tO\nevidence\tO\nof\tO\nseizure\tB-Disease\nactivity\tO\n.\tO\n\nMidline\tO\nB3\tO\nserotonin\tB-Chemical\nnerves\tO\nin\tO\nrat\tO\nmedulla\tO\nare\tO\ninvolved\tO\nin\tO\nhypotensive\tB-Disease\neffect\tO\nof\tO\nmethyldopa\tB-Chemical\n.\tO\n\nPrevious\tO\nexperiments\tO\nin\tO\nthis\tO\nlaboratory\tO\nhave\tO\nshown\tO\nthat\tO\nmicroinjection\tO\nof\tO\nmethyldopa\tB-Chemical\nonto\tO\nthe\tO\nventrolateral\tO\ncells\tO\nof\tO\nthe\tO\nB3\tO\nserotonin\tB-Chemical\nneurons\tO\nin\tO\nthe\tO\nmedulla\tO\nelicits\tO\na\tO\nhypotensive\tB-Disease\nresponse\tO\nmediated\tO\nby\tO\na\tO\nprojection\tO\ndescending\tO\ninto\tO\nthe\tO\nspinal\tO\ncord\tO\n.\tO\n\nThe\tO\npresent\tO\nexperiments\tO\nwere\tO\ndesigned\tO\nto\tO\ninvestigate\tO\nthe\tO\nrole\tO\nof\tO\nthe\tO\nmidline\tO\ncells\tO\nof\tO\nthe\tO\nB3\tO\nserotonin\tB-Chemical\nneurons\tO\nin\tO\nthe\tO\nmedulla\tO\n,\tO\ncoinciding\tO\nwith\tO\nthe\tO\nraphe\tO\nmagnus\tO\n.\tO\n\nIn\tO\nspontaneously\tO\nhypertensive\tB-Disease\n,\tO\nstroke\tB-Disease\n-\tO\nprone\tO\nrats\tO\n,\tO\nmicroinjection\tO\nof\tO\nmethyldopa\tB-Chemical\ninto\tO\nthe\tO\narea\tO\nof\tO\nthe\tO\nmidline\tO\nB3\tO\nserotonin\tB-Chemical\ncell\tO\ngroup\tO\nin\tO\nthe\tO\nventral\tO\nmedulla\tO\ncaused\tO\na\tO\npotent\tO\nhypotension\tB-Disease\nof\tO\n30\tO\n-\tO\n40\tO\nmm\tO\nHg\tO\n,\tO\nwhich\tO\nwas\tO\nmaximal\tO\n2\tO\n-\tO\n3\tO\nh\tO\nafter\tO\nadministration\tO\nand\tO\nwas\tO\nabolished\tO\nby\tO\nthe\tO\nserotonin\tB-Chemical\nneurotoxin\tO\n5\tB-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\ndihydroxytryptamine\tI-Chemical\n(\tO\n5\tB-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\nDHT\tI-Chemical\n)\tO\ninjected\tO\nintracerebroventricularly\tO\n.\tO\n\nHowever\tO\n,\tO\nintraspinal\tO\ninjection\tO\nof\tO\n5\tB-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\nDHT\tI-Chemical\nto\tO\nproduce\tO\na\tO\nmore\tO\nselective\tO\nlesion\tO\nof\tO\nonly\tO\ndescending\tO\nserotonin\tB-Chemical\nprojections\tO\nin\tO\nthe\tO\nspinal\tO\ncord\tO\ndid\tO\nnot\tO\naffect\tO\nthis\tO\nhypotension\tB-Disease\n.\tO\n\nFurther\tO\n,\tO\n5\tB-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\nDHT\tI-Chemical\nlesion\tO\nof\tO\nserotonin\tB-Chemical\nnerves\tO\ntravelling\tO\nin\tO\nthe\tO\nmedian\tO\nforebrain\tO\nbundle\tO\n,\tO\none\tO\nof\tO\nthe\tO\nmain\tO\nascending\tO\npathways\tO\nfrom\tO\nthe\tO\nB3\tO\nserotonin\tB-Chemical\ncells\tO\n,\tO\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nfall\tO\nin\tO\nblood\tO\npressure\tO\nassociated\tO\nwith\tO\na\tO\nmidline\tO\nB3\tO\nserotonin\tB-Chemical\nmethyldopa\tB-Chemical\ninjection\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\ntherefore\tO\nthat\tO\n,\tO\nunlike\tO\nthe\tO\nventrolateral\tO\nB3\tO\ncells\tO\nwhich\tO\nmediate\tO\na\tO\nmethyldopa\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nvia\tO\ndescending\tO\nprojections\tO\n,\tO\nthe\tO\nmidline\tO\nserotonin\tB-Chemical\nB3\tO\ncells\tO\nin\tO\nthe\tO\nmedulla\tO\ncontribute\tO\nto\tO\nthe\tO\nhypotensive\tB-Disease\naction\tO\nof\tO\nmethyldopa\tB-Chemical\n,\tO\neither\tO\nby\tO\nway\tO\nof\tO\nan\tO\nascending\tO\nprojection\tO\nwhich\tO\ndoes\tO\nnot\tO\npass\tO\nthrough\tO\nthe\tO\nmedian\tO\nforebrain\tO\nbundle\tO\n,\tO\nor\tO\nthrough\tO\na\tO\nprojection\tO\nrestricted\tO\nto\tO\nthe\tO\ncaudal\tO\nbrainstem\tO\n.\tO\n\nAntiarrhythmic\tO\nplasma\tO\nconcentrations\tO\nof\tO\ncibenzoline\tB-Chemical\non\tO\ncanine\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\n.\tO\n\nUsing\tO\ntwo\tO\n-\tO\nstage\tO\ncoronary\tO\nligation\tO\n-\tO\n,\tO\ndigitalis\tB-Chemical\n-\tO\n,\tO\nand\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\ncanine\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\n,\tO\nantiarrhythmic\tO\neffects\tO\nof\tO\ncibenzoline\tB-Chemical\nwere\tO\nexamined\tO\nand\tO\nthe\tO\nminimum\tO\neffective\tO\nplasma\tO\nconcentration\tO\nfor\tO\neach\tO\narrhythmia\tB-Disease\nmodel\tO\nwas\tO\ndetermined\tO\n.\tO\n\nCibenzoline\tB-Chemical\nsuppressed\tO\nall\tO\nthe\tO\narrhythmias\tB-Disease\n,\tO\nand\tO\nthe\tO\nminimum\tO\neffective\tO\nplasma\tO\nconcentrations\tO\nfor\tO\narrhythmias\tB-Disease\ninduced\tO\nby\tO\n24\tO\n-\tO\nh\tO\ncoronary\tO\nligation\tO\n,\tO\n48\tO\n-\tO\nh\tO\ncoronary\tO\nligation\tO\n,\tO\ndigitalis\tB-Chemical\n,\tO\nand\tO\nadrenaline\tB-Chemical\nwere\tO\n1\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n9\tO\n(\tO\nby\tO\n8\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\n,\tO\n1\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n5\tO\n(\tO\nby\tO\n8\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\n,\tO\n0\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\n(\tO\nby\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\n,\tO\nand\tO\n3\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n3\tO\n(\tO\nby\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nmicrograms\tO\n/\tO\nml\tO\n,\tO\nrespectively\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSDM\tO\n,\tO\nn\tO\n=\tO\n6\tO\n-\tO\n7\tO\n)\tO\n.\tO\n\nThe\tO\nconcentration\tO\nfor\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\narrhythmia\tB-Disease\nwas\tO\nsignificantly\tO\nhigher\tO\nthan\tO\nthose\tO\nfor\tO\nthe\tO\nother\tO\ntypes\tO\nof\tO\narrhythmias\tB-Disease\n.\tO\n\nThis\tO\npharmacological\tO\nprofile\tO\nis\tO\nsimilar\tO\nto\tO\nthose\tO\nof\tO\nmexiletine\tB-Chemical\nand\tO\ntocainide\tB-Chemical\n,\tO\nand\tO\nall\tO\nthree\tO\ndrugs\tO\nhave\tO\ncentral\tO\nnervous\tO\nsystem\tO\n(\tO\nCNS\tO\n)\tO\nstimulant\tO\naction\tO\n.\tO\n\nBecause\tO\ncibenzoline\tB-Chemical\nhad\tO\nonly\tO\nweak\tO\nhypotensive\tB-Disease\nand\tO\nsinus\tO\nnode\tO\ndepressive\tB-Disease\neffects\tO\nand\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\norally\tO\nactive\tO\nwhen\tO\ngiven\tO\nto\tO\ncoronary\tO\nligation\tO\narrhythmia\tB-Disease\ndogs\tO\n,\tO\nits\tO\nclinical\tO\nusefulness\tO\nis\tO\nexpected\tO\n.\tO\n\nContinuous\tO\nambulatory\tO\nECG\tO\nmonitoring\tO\nduring\tO\nfluorouracil\tB-Chemical\ntherapy\tO\n:\tO\na\tO\nprospective\tO\nstudy\tO\n.\tO\n\nAlthough\tO\nthere\tO\nhave\tO\nbeen\tO\nanecdotal\tO\nreports\tO\nof\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nassociated\tO\nwith\tO\nfluorouracil\tB-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\ntherapy\tO\n,\tO\nthis\tO\nphenomenon\tO\nhas\tO\nnot\tO\nbeen\tO\nstudied\tO\nin\tO\na\tO\nsystematic\tO\nfashion\tO\n.\tO\n\nWe\tO\nprospectively\tO\nperformed\tO\ncontinuous\tO\nambulatory\tO\nECG\tO\nmonitoring\tO\non\tO\n25\tO\npatients\tO\nundergoing\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninfusion\tO\nfor\tO\ntreatment\tO\nof\tO\nsolid\tO\ntumors\tB-Disease\nin\tO\norder\tO\nto\tO\nassess\tO\nthe\tO\nincidence\tO\nof\tO\nischemic\tB-Disease\nST\tO\nchanges\tO\n.\tO\n\nPatients\tO\nwere\tO\nmonitored\tO\nfor\tO\n23\tO\n+\tO\n/\tO\n-\tO\n4\tO\nhours\tO\nbefore\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninfusion\tO\n,\tO\nand\tO\n98\tO\n+\tO\n/\tO\n-\tO\n9\tO\nhours\tO\nduring\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninfusion\tO\n.\tO\n\nAnginal\tB-Disease\nepisodes\tO\nwere\tO\nrare\tO\n:\tO\nonly\tO\none\tO\npatient\tO\nhad\tO\nangina\tB-Disease\n(\tO\nduring\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninfusion\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nasymptomatic\tO\nST\tO\nchanges\tO\n(\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n1\tO\nmm\tO\nST\tO\ndeviation\tO\n)\tO\nwere\tO\ncommon\tO\n:\tO\nsix\tO\nof\tO\n25\tO\npatients\tO\n(\tO\n24\tO\n%\tO\n)\tO\nhad\tO\nST\tO\nchanges\tO\nbefore\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninfusion\tO\nv\tO\n17\tO\n(\tO\n68\tO\n%\tO\n)\tO\nduring\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninfusion\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nischemic\tB-Disease\nepisodes\tO\nper\tO\npatient\tO\nper\tO\nhour\tO\nwas\tO\n0\tO\n.\tO\n05\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n02\tO\nprior\tO\nto\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninfusion\tO\nv\tO\n0\tO\n.\tO\n13\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n03\tO\nduring\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninfusion\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n001\tO\n)\tO\n;\tO\nthe\tO\nduration\tO\nof\tO\nECG\tO\nchanges\tO\nwas\tO\n0\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n3\tO\nminutes\tO\nper\tO\npatient\tO\nper\tO\nhour\tO\nbefore\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nv\tO\n1\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n5\tO\nminutes\tO\nper\tO\npatient\tO\nper\tO\nhour\tO\nduring\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n(\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nECG\tO\nchanges\tO\nwere\tO\nmore\tO\ncommon\tO\namong\tO\npatients\tO\nwith\tO\nknown\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n.\tO\n\nThere\tO\nwere\tO\ntwo\tO\ncases\tO\nof\tO\nsudden\tB-Disease\ndeath\tI-Disease\n,\tO\nboth\tO\nof\tO\nwhich\tO\noccurred\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nchemotherapy\tO\ncourse\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninfusion\tO\nis\tO\nassociated\tO\nwith\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nsilent\tO\nST\tO\nsegment\tO\ndeviation\tO\nsuggestive\tO\nof\tO\nischemia\tB-Disease\n,\tO\nparticularly\tO\namong\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n.\tO\n\nThe\tO\nmechanism\tO\nand\tO\nclinical\tO\nsignificance\tO\nof\tO\nthese\tO\nECG\tO\nchanges\tO\nremain\tO\nto\tO\nbe\tO\ndetermined\tO\n.\tO\n\nNature\tO\n,\tO\ntime\tO\ncourse\tO\nand\tO\ndose\tO\ndependence\tO\nof\tO\nzidovudine\tB-Chemical\n-\tO\nrelated\tO\nside\tO\neffects\tO\n:\tO\nresults\tO\nfrom\tO\nthe\tO\nMulticenter\tO\nCanadian\tO\nAzidothymidine\tB-Chemical\nTrial\tO\n.\tO\n\nTo\tO\ncharacterize\tO\nthe\tO\nnature\tO\n,\tO\ntime\tO\ncourse\tO\nand\tO\ndose\tO\ndependency\tO\nof\tO\nzidovudine\tB-Chemical\n-\tO\nrelated\tO\nside\tO\neffects\tO\n,\tO\nwe\tO\nundertook\tO\na\tO\nmulticenter\tO\n,\tO\nprospective\tO\n,\tO\ndose\tO\n-\tO\nrange\tO\nfinding\tO\nstudy\tO\n.\tO\n\nOur\tO\nstudy\tO\ngroup\tO\nconsisted\tO\nof\tO\n74\tO\nHIV\tO\n-\tO\npositive\tO\nhomosexual\tO\nmen\tO\nbelonging\tO\nto\tO\ngroups\tO\nII\tO\nB\tO\n,\tO\nIII\tO\nand\tO\nIV\tO\nC2\tO\nfrom\tO\nthe\tO\nCenters\tO\nfor\tO\nDisease\tO\nControl\tO\n(\tO\nCDC\tO\n)\tO\nclassification\tO\nof\tO\nHIV\tB-Disease\ndisease\tI-Disease\n.\tO\n\nFollowing\tO\na\tO\n3\tO\n-\tO\nweek\tO\nobservation\tO\nperiod\tO\n,\tO\nvolunteers\tO\nwere\tO\ntreated\tO\nwith\tO\nzidovudine\tB-Chemical\n600\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\n18\tO\nweeks\tO\n,\tO\n900\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\n9\tO\nweeks\tO\nand\tO\n1200\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\n9\tO\nweeks\tO\n,\tO\nfollowed\tO\nby\tO\na\tO\nwashout\tO\nperiod\tO\nof\tO\n6\tO\nweeks\tO\nafter\tO\nwhich\tO\nthey\tO\nwere\tO\nre\tO\n-\tO\nstarted\tO\non\tO\n1200\tO\nmg\tO\n/\tO\nday\tO\nor\tO\nthe\tO\nhighest\tO\ntolerated\tO\ndose\tO\nat\tO\n8\tO\n-\tO\nhourly\tO\nintervals\tO\n.\tO\n\nSubjects\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\n4\tO\n-\tO\nhourly\tO\nor\tO\n8\tO\n-\tO\nhourly\tO\nregimens\tO\nwithin\tO\nCDC\tO\ngroups\tO\nwhile\tO\ntaking\tO\n600\tO\nand\tO\n1200\tO\nmg\tO\n/\tO\nday\tO\n.\tO\n\nClinical\tO\nand\tO\nlaboratory\tO\nevaluations\tO\nwere\tO\nperformed\tO\nat\tO\n3\tO\n-\tO\nweek\tO\nintervals\tO\n.\tO\n\nSymptomatic\tO\nadverse\tO\neffects\tO\nwere\tO\npresent\tO\nin\tO\n96\tO\n%\tO\nof\tO\nsubjects\tO\n,\tO\nmost\tO\ncommonly\tO\nnausea\tB-Disease\n(\tO\n64\tO\n%\tO\n)\tO\n,\tO\nfatigue\tB-Disease\n(\tO\n55\tO\n%\tO\n)\tO\nand\tO\nheadache\tB-Disease\n(\tO\n49\tO\n%\tO\n)\tO\n.\tO\n\nThese\tO\nwere\tO\ngenerally\tO\nself\tO\n-\tO\nlimited\tO\n,\tO\nreappearing\tO\nbriefly\tO\nat\tO\neach\tO\ndose\tO\nincrement\tO\n.\tO\n\nA\tO\ndecrease\tO\nin\tO\nhemoglobin\tO\noccurred\tO\nshortly\tO\nafter\tO\ninitiation\tO\nof\tO\ntherapy\tO\n.\tO\n\nThis\tO\nwas\tO\nnot\tO\ndose\tO\ndependent\tO\nand\tO\nreversed\tO\nrapidly\tO\nupon\tO\ndiscontinuation\tO\nof\tO\ntreatment\tO\n.\tO\n\nA\tO\nred\tO\nblood\tO\ncell\tO\ncount\tO\ndecrease\tO\n,\tO\na\tO\nmean\tO\ncell\tO\nvolume\tO\nincrease\tO\nand\tO\na\tO\ngranulocyte\tO\ncount\tO\ndecrease\tO\ndeveloped\tO\nearly\tO\nin\tO\na\tO\ndose\tO\n-\tO\nindependent\tO\nfashion\tO\n,\tO\nreverting\tO\nat\tO\nleast\tO\npartially\tO\nduring\tO\nthe\tO\nwashout\tO\nphase\tO\n.\tO\n\nThe\tO\ndecrease\tO\nin\tO\nreticulocyte\tO\ncount\tO\nwas\tO\ndose\tO\nrelated\tO\nbetween\tO\n600\tO\nand\tO\n900\tO\nmg\tO\n/\tO\nday\tO\nwith\tO\nno\tO\nfurther\tO\nchange\tO\nwhen\tO\nthe\tO\ndose\tO\nwas\tO\nescalated\tO\nto\tO\n1200\tO\nmg\tO\n/\tO\nday\tO\n.\tO\n\nBone\tO\nmarrow\tO\nchanges\tO\noccurred\tO\nrapidly\tO\nas\tO\ndemonstrated\tO\nby\tO\nmegaloblastosis\tB-Disease\nin\tO\n95\tO\n%\tO\nof\tO\n65\tO\nspecimens\tO\nat\tO\nweek\tO\n18\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nNational\tO\nproject\tO\non\tO\nthe\tO\nprevention\tO\nof\tO\nmother\tO\n-\tO\nto\tO\n-\tO\ninfant\tO\ninfection\tB-Disease\nby\tI-Disease\nhepatitis\tI-Disease\nB\tI-Disease\nvirus\tI-Disease\nin\tO\nJapan\tO\n.\tO\n\nIn\tO\nJapan\tO\n,\tO\na\tO\nnationwide\tO\nprevention\tO\nprogram\tO\nagainst\tO\nmother\tO\n-\tO\nto\tO\n-\tO\ninfant\tO\ninfection\tB-Disease\nby\tI-Disease\nhepatitis\tI-Disease\nB\tI-Disease\nvirus\tI-Disease\n(\tO\nHBV\tO\n)\tO\nstarted\tO\nin\tO\n1985\tO\n.\tO\n\nThis\tO\nprogram\tO\nconsists\tO\nof\tO\ndouble\tO\nscreenings\tO\nof\tO\npregnant\tO\nwomen\tO\nand\tO\nprophylactic\tO\ntreatment\tO\nto\tO\nthe\tO\ninfants\tO\nborn\tO\nto\tO\nboth\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nsurface\tI-Chemical\nantigen\tI-Chemical\n(\tO\nHBsAg\tB-Chemical\n)\tO\nand\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\ne\tI-Chemical\nantigen\tI-Chemical\n(\tO\nHBeAg\tB-Chemical\n)\tO\npositive\tO\nmothers\tO\n.\tO\n\nThese\tO\ninfants\tO\nare\tO\ntreated\tO\nwith\tO\ntwo\tO\ninjections\tO\nof\tO\nhepatitis\tB-Disease\nB\tI-Disease\nimmune\tO\nglobulin\tO\n(\tO\nHBIG\tO\n)\tO\nand\tO\nat\tO\nleast\tO\nthree\tO\ninjections\tO\nof\tO\nplasma\tO\nderived\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nvaccine\tI-Chemical\n.\tO\n\nWe\tO\nsent\tO\nquestionnaires\tO\nabout\tO\nthe\tO\nnumbers\tO\nof\tO\neach\tO\nprocedure\tO\nor\tO\nexamination\tO\nduring\tO\nnine\tO\nmonths\tO\nof\tO\ninvestigation\tO\nperiod\tO\nto\tO\neach\tO\nlocal\tO\ngovernment\tO\nin\tO\n1986\tO\nand\tO\n1987\tO\n.\tO\n\n93\tO\n.\tO\n4\tO\n%\tO\npregnant\tO\nwomen\tO\nhad\tO\nthe\tO\nchance\tO\nto\tO\nbe\tO\nexamined\tO\nfor\tO\nHBsAg\tB-Chemical\n,\tO\nand\tO\nthe\tO\npositive\tO\nrate\tO\nwas\tO\n1\tO\n.\tO\n4\tO\nto\tO\n1\tO\n.\tO\n5\tO\n%\tO\n.\tO\n\nThe\tO\nHBeAg\tB-Chemical\npositive\tO\nrate\tO\nin\tO\nHBsAg\tB-Chemical\npositive\tO\nwas\tO\n23\tO\nto\tO\n26\tO\n%\tO\n.\tO\n\nThe\tO\nHBsAg\tB-Chemical\npositive\tO\nrate\tO\nin\tO\nneonates\tO\nand\tO\nin\tO\ninfants\tO\nbefore\tO\ntwo\tO\nmonths\tO\nwere\tO\n3\tO\n%\tO\nand\tO\n2\tO\n%\tO\nrespectively\tO\n.\tO\n\nSome\tO\nproblems\tO\nmay\tO\narise\tO\n,\tO\nbecause\tO\n27\tO\nto\tO\n30\tO\n%\tO\nof\tO\ninfants\tO\nneed\tO\nthe\tO\nfourth\tO\nvaccination\tO\nin\tO\nsome\tO\nrestricted\tO\nareas\tO\n.\tO\n\nInvolvement\tO\nof\tO\nthe\tO\nmu\tO\n-\tO\nopiate\tO\nreceptor\tO\nin\tO\nperipheral\tO\nanalgesia\tB-Disease\n.\tO\n\nThe\tO\nintradermal\tO\ninjection\tO\nof\tO\nmu\tO\n(\tO\nmorphine\tB-Chemical\n,\tO\nTyr\tB-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\nAla\tI-Chemical\n-\tI-Chemical\nGly\tI-Chemical\n-\tI-Chemical\nNMe\tI-Chemical\n-\tI-Chemical\nPhe\tI-Chemical\n-\tI-Chemical\nGly\tI-Chemical\n-\tI-Chemical\nol\tI-Chemical\nand\tO\nmorphiceptin\tB-Chemical\n)\tO\n,\tO\nkappa\tO\n(\tO\ntrans\tB-Chemical\n-\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichloro\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\npyrrolidinyl\tI-Chemical\n)\tI-Chemical\ncyclohexyl\tI-Chemical\n]\tI-Chemical\nbenzeneactemide\tI-Chemical\n)\tO\nand\tO\ndelta\tO\n(\tO\n[\tB-Chemical\nD\tI-Chemical\n-\tI-Chemical\nPen2\tI-Chemical\n.\tI-Chemical\n5\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nenkephalin\tI-Chemical\nand\tO\n[\tB-Chemical\nD\tI-Chemical\n-\tI-Chemical\nSer2\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\nLeu\tI-Chemical\n]\tI-Chemical\nenkephalin\tI-Chemical\n-\tI-Chemical\nThr\tI-Chemical\n)\tO\nselective\tO\nopioid\tO\n-\tO\nagonists\tO\n,\tO\nby\tO\nthemselves\tO\n,\tO\ndid\tO\nnot\tO\nsignificantly\tO\naffect\tO\nthe\tO\nmechanical\tO\nnociceptive\tO\nthreshold\tO\nin\tO\nthe\tO\nhindpaw\tO\nof\tO\nthe\tO\nrat\tO\n.\tO\n\nIntradermal\tO\ninjection\tO\nof\tO\nmu\tO\n,\tO\nbut\tO\nnot\tO\ndelta\tO\nor\tO\nkappa\tO\nopioid\tO\n-\tO\nagonists\tO\n,\tO\nhowever\tO\n,\tO\nproduced\tO\ndose\tO\n-\tO\ndependent\tO\ninhibition\tO\nof\tO\nprostaglandin\tB-Chemical\nE2\tI-Chemical\n-\tO\ninduced\tO\nhyperalgesia\tB-Disease\n.\tO\n\nThe\tO\nanalgesic\tO\neffect\tO\nof\tO\nthe\tO\nmu\tO\n-\tO\nagonist\tO\nmorphine\tB-Chemical\nwas\tO\ndose\tO\n-\tO\ndependently\tO\nantagonized\tO\nby\tO\nnaloxone\tB-Chemical\nand\tO\nprevented\tO\nby\tO\nco\tO\n-\tO\ninjection\tO\nof\tO\npertussis\tO\ntoxin\tO\n.\tO\n\nMorphine\tB-Chemical\ndid\tO\nnot\tO\n,\tO\nhowever\tO\n,\tO\nalter\tO\nthe\tO\nhyperalgesia\tB-Disease\ninduced\tO\nby\tO\n8\tB-Chemical\n-\tI-Chemical\nbromo\tI-Chemical\ncyclic\tI-Chemical\nadenosine\tI-Chemical\nmonophosphate\tI-Chemical\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nthe\tO\nanalgesic\tO\naction\tO\nof\tO\nopioids\tO\non\tO\nthe\tO\nperipheral\tO\nterminals\tO\nof\tO\nprimary\tO\nafferents\tO\nis\tO\nvia\tO\na\tO\nbinding\tO\nsite\tO\nwith\tO\ncharacteristics\tO\nof\tO\nthe\tO\nmu\tO\n-\tO\nopioid\tO\nreceptor\tO\nand\tO\nthat\tO\nthis\tO\naction\tO\nis\tO\nmediated\tO\nby\tO\ninhibition\tO\nof\tO\nthe\tO\ncyclic\tB-Chemical\nadenosine\tI-Chemical\nmonophosphate\tI-Chemical\nsecond\tO\nmessenger\tO\nsystem\tO\n.\tO\n\nInvolvement\tO\nof\tO\nlocus\tO\ncoeruleus\tO\nand\tO\nnoradrenergic\tO\nneurotransmission\tO\nin\tO\nfentanyl\tB-Chemical\n-\tO\ninduced\tO\nmuscular\tB-Disease\nrigidity\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nWhereas\tO\nmuscular\tB-Disease\nrigidity\tI-Disease\nis\tO\na\tO\nwell\tO\n-\tO\nknown\tO\nside\tO\neffect\tO\nthat\tO\nis\tO\nassociated\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\nfentanyl\tB-Chemical\nanesthesia\tO\n,\tO\na\tO\npaucity\tO\nof\tO\ninformation\tO\nexists\tO\nwith\tO\nregard\tO\nto\tO\nits\tO\nunderlying\tO\nmechanism\tO\n(\tO\ns\tO\n)\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nin\tO\nthis\tO\nstudy\tO\nthe\tO\npossible\tO\nengagement\tO\nof\tO\nlocus\tO\ncoeruleus\tO\nof\tO\nthe\tO\npons\tO\nin\tO\nthis\tO\nphenomenon\tO\n,\tO\nusing\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nanesthetized\tO\nwith\tO\nketamine\tB-Chemical\n.\tO\n\nUnder\tO\nproper\tO\ncontrol\tO\nof\tO\nrespiration\tO\n,\tO\nbody\tO\ntemperature\tO\nand\tO\nend\tO\n-\tO\ntidal\tO\nCO2\tB-Chemical\n,\tO\nintravenous\tO\nadministration\tO\nof\tO\nfentanyl\tB-Chemical\n(\tO\n50\tO\nor\tO\n100\tO\nmicrograms\tO\n/\tO\nkg\tO\n)\tO\nconsistently\tO\npromoted\tO\nan\tO\nincrease\tO\nin\tO\nelectromyographic\tO\nactivity\tO\nrecorded\tO\nfrom\tO\nthe\tO\ngastrocnemius\tO\nand\tO\nabdominal\tO\nrectus\tO\nmuscles\tO\n.\tO\n\nSuch\tO\nan\tO\ninduced\tO\nmuscular\tB-Disease\nrigidity\tI-Disease\nby\tO\nthe\tO\nnarcotic\tO\nagent\tO\nwas\tO\nsignificantly\tO\nantagonized\tO\nor\tO\neven\tO\nreduced\tO\nby\tO\nprior\tO\nelectrolytic\tO\nlesions\tO\nof\tO\nthe\tO\nlocus\tO\ncoeruleus\tO\nor\tO\npretreatment\tO\nwith\tO\nthe\tO\nalpha\tO\n-\tO\nadrenoceptor\tO\nblocker\tO\n,\tO\nprazosin\tB-Chemical\n.\tO\n\nMicroinjection\tO\nof\tO\nfentanyl\tB-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\nmicrograms\tO\n/\tO\n50\tO\nnl\tO\n)\tO\ndirectly\tO\ninto\tO\nthis\tO\npontine\tO\nnucleus\tO\n,\tO\non\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nelicited\tO\ndiscernible\tO\nelectromyographic\tO\nexcitation\tO\n.\tO\n\nIt\tO\nis\tO\nspeculated\tO\nthat\tO\nthe\tO\ninduction\tO\nof\tO\nmuscular\tB-Disease\nrigidity\tI-Disease\nby\tO\nfentanyl\tB-Chemical\nmay\tO\ninvolve\tO\nthe\tO\ncoerulospinal\tO\nnoradrenergic\tO\nfibers\tO\nto\tO\nthe\tO\nspinal\tO\nmotoneurons\tO\n.\tO\n\nDexmedetomidine\tB-Chemical\n,\tO\nacting\tO\nthrough\tO\ncentral\tO\nalpha\tO\n-\tO\n2\tO\nadrenoceptors\tO\n,\tO\nprevents\tO\nopiate\tO\n-\tO\ninduced\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nThe\tO\nhighly\tO\n-\tO\nselective\tO\nalpha\tO\n-\tO\n2\tO\nadrenergic\tO\nagonist\tO\ndexmedetomidine\tB-Chemical\n(\tO\nD\tB-Chemical\n-\tI-Chemical\nMED\tI-Chemical\n)\tO\nis\tO\ncapable\tO\nof\tO\ninducing\tO\nmuscle\tB-Disease\nflaccidity\tI-Disease\nand\tO\nanesthesia\tO\nin\tO\nrats\tO\nand\tO\ndogs\tO\n.\tO\n\nIntense\tO\ngeneralized\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\nis\tO\nan\tO\nundesirable\tO\nside\tO\neffect\tO\nof\tO\npotent\tO\nopiate\tO\nagonists\tO\n.\tO\n\nAlthough\tO\nthe\tO\nneurochemistry\tO\nof\tO\nopiate\tO\n-\tO\ninduced\tO\nrigidity\tB-Disease\nhas\tO\nyet\tO\nto\tO\nbe\tO\nfully\tO\nelucidated\tO\n,\tO\nrecent\tO\nwork\tO\nsuggests\tO\na\tO\nrole\tO\nfor\tO\na\tO\ncentral\tO\nadrenergic\tO\nmechanism\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthe\tO\nauthors\tO\ndetermined\tO\nif\tO\ntreatment\tO\nwith\tO\nD\tB-Chemical\n-\tI-Chemical\nMED\tI-Chemical\nprevents\tO\nthe\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\ncaused\tO\nby\tO\nhigh\tO\n-\tO\ndose\tO\nalfentanil\tB-Chemical\nanesthesia\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nAnimals\tO\n(\tO\nn\tO\n=\tO\n42\tO\n)\tO\nwere\tO\ntreated\tO\nintraperitoneally\tO\nwith\tO\none\tO\nof\tO\nthe\tO\nfollowing\tO\nsix\tO\nregimens\tO\n:\tO\n1\tO\n)\tO\nL\tO\n-\tO\nMED\tO\n(\tO\nthe\tO\ninactive\tO\nL\tO\n-\tO\nisomer\tO\nof\tO\nmedetomidine\tB-Chemical\n)\tO\n,\tO\n30\tO\nmicrograms\tO\n/\tO\nkg\tO\n;\tO\n2\tO\n)\tO\nD\tB-Chemical\n-\tI-Chemical\nMED\tI-Chemical\n,\tO\n10\tO\nmicrograms\tO\n/\tO\nkg\tO\n;\tO\n3\tO\n)\tO\nD\tB-Chemical\n-\tI-Chemical\nMED\tI-Chemical\n,\tO\n30\tO\nmicrograms\tO\n/\tO\nkg\tO\n;\tO\n4\tO\n)\tO\nD\tB-Chemical\n-\tI-Chemical\nMED\tI-Chemical\n[\tO\n30\tO\nmicrograms\tO\n/\tO\nkg\tO\n]\tO\nand\tO\nthe\tO\ncentral\tO\n-\tO\nacting\tO\nalpha\tO\n-\tO\n2\tO\nantagonist\tO\n,\tO\nidazoxan\tB-Chemical\n[\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n]\tO\n;\tO\n5\tO\n)\tO\nD\tB-Chemical\n-\tI-Chemical\nMED\tI-Chemical\n[\tO\n30\tO\nmicrograms\tO\n/\tO\nkg\tO\n]\tO\nand\tO\nthe\tO\nperipheral\tO\n-\tO\nacting\tO\nalpha\tO\n-\tO\n2\tO\nantagonist\tO\nDG\tB-Chemical\n-\tI-Chemical\n5128\tI-Chemical\n[\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n]\tO\n,\tO\nor\tO\n;\tO\n6\tO\n)\tO\nsaline\tO\n.\tO\n\nBaseline\tO\nelectromyographic\tO\nactivity\tO\nwas\tO\nrecorded\tO\nfrom\tO\nthe\tO\ngastrocnemius\tO\nmuscle\tO\nbefore\tO\nand\tO\nafter\tO\ndrug\tO\ntreatment\tO\n.\tO\n\nEach\tO\nrat\tO\nwas\tO\nthen\tO\ninjected\tO\nwith\tO\nalfentanil\tB-Chemical\n(\tO\nALF\tB-Chemical\n,\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\n.\tO\n\nALF\tB-Chemical\ninjection\tO\nresulted\tO\nin\tO\na\tO\nmarked\tO\nincrease\tO\nin\tO\nhindlimb\tO\nEMG\tO\nactivity\tO\nin\tO\nthe\tO\nL\tO\n-\tO\nMED\tO\ntreatment\tO\ngroup\tO\nwhich\tO\nwas\tO\nindistinguishable\tO\nfrom\tO\nthat\tO\nseen\tO\nin\tO\nanimals\tO\ntreated\tO\nwith\tO\nsaline\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nD\tB-Chemical\n-\tI-Chemical\nMED\tI-Chemical\nprevented\tO\nalfentanil\tB-Chemical\n-\tO\ninduced\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nfashion\tO\n.\tO\n\nThe\tO\nsmall\tO\nEMG\tO\nvalues\tO\nobtained\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\nD\tB-Chemical\n-\tI-Chemical\nMED\tI-Chemical\ngroup\tO\nwere\tO\ncomparable\tO\nwith\tO\nthose\tO\nrecorded\tO\nin\tO\nearlier\tO\nstudies\tO\nfrom\tO\ncontrol\tO\nanimals\tO\nnot\tO\ngiven\tO\nany\tO\nopiate\tO\n.\tO\n\nThe\tO\nhigh\tO\n-\tO\ndose\tO\nD\tB-Chemical\n-\tI-Chemical\nMED\tI-Chemical\nanimals\tO\nwere\tO\nflaccid\tO\n,\tO\nakinetic\tB-Disease\n,\tO\nand\tO\nlacked\tO\na\tO\nstartle\tB-Disease\nresponse\tO\nduring\tO\nthe\tO\nentire\tO\nexperimental\tO\nperiod\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nSome\tO\ncentral\tO\neffects\tO\nof\tO\nrepeated\tO\ntreatment\tO\nwith\tO\nfluvoxamine\tB-Chemical\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\neffect\tO\nof\tO\nrepeated\tO\ntreatment\tO\nwith\tO\nfluvoxamine\tB-Chemical\n,\tO\na\tO\nselective\tO\nserotonin\tB-Chemical\nuptake\tO\ninhibitor\tO\n,\tO\non\tO\nbehavioral\tO\neffects\tO\nof\tO\ndopaminomimetics\tO\nand\tO\nmethoxamine\tB-Chemical\nand\tO\non\tO\nthe\tO\nanimal\tO\nbehavior\tO\nin\tO\nthe\tO\n\"\tO\nbehavioral\tO\ndespair\tO\n\"\tO\ntest\tO\n.\tO\n\nA\tO\nrepeated\tO\ntreatment\tO\nwith\tO\nfluvoxamine\tB-Chemical\n(\tO\ntwice\tO\ndaily\tO\nfor\tO\n14\tO\ndays\tO\n)\tO\npotentiated\tO\nin\tO\nmice\tO\nand\tO\nin\tO\nrats\tO\n(\tO\nweaker\tO\n)\tO\nthe\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n.\tO\n\nThe\tO\nhyperactivity\tB-Disease\ninduced\tO\nby\tO\nnomifensine\tB-Chemical\nin\tO\nmice\tO\nremained\tO\nunaffected\tO\nby\tO\nfluvoxamine\tB-Chemical\n.\tO\n\nThe\tO\nstimulation\tO\nof\tO\nlocomotor\tO\nactivity\tO\nby\tO\nintracerebroventricularly\tO\nadministered\tO\nmethoxamine\tB-Chemical\nwas\tO\nnot\tO\naffected\tO\nby\tO\nrepeated\tO\ntreatment\tO\nwith\tO\nfluvoxamine\tB-Chemical\n.\tO\n\nGiven\tO\nthree\tO\ntimes\tO\nfluvoxamine\tB-Chemical\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nimmobilization\tO\ntime\tO\nin\tO\nthe\tO\n\"\tO\nbehavioral\tO\ndespair\tO\n\"\tO\ntest\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nfluvoxamine\tB-Chemical\ngiven\tO\nrepeatedly\tO\nacts\tO\ndifferently\tO\nthan\tO\ncitalopram\tB-Chemical\n,\tO\nanother\tO\nselective\tO\nserotonin\tB-Chemical\nuptake\tO\ninhibitor\tO\n,\tO\nand\tO\ndiffers\tO\nalso\tO\nfrom\tO\nother\tO\nantidepressant\tO\ndrugs\tO\n.\tO\n\nProtective\tO\neffect\tO\nof\tO\na\tO\nspecific\tO\nplatelet\tO\n-\tO\nactivating\tO\nfactor\tO\nantagonist\tO\n,\tO\nBN\tB-Chemical\n52021\tI-Chemical\n,\tO\non\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\ncardiovascular\tB-Disease\nimpairments\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nAdministration\tO\nof\tO\nthe\tO\nlocal\tO\nanaesthetic\tO\nbupivacaine\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nor\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nto\tO\nrats\tO\nelicited\tO\na\tO\nmarked\tO\ndecrease\tB-Disease\nof\tI-Disease\nmean\tI-Disease\narterial\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\n(\tI-Disease\nMBP\tI-Disease\n)\tI-Disease\nand\tI-Disease\nheart\tI-Disease\nrate\tI-Disease\n(\tI-Disease\nHR\tI-Disease\n)\tI-Disease\nleading\tO\nto\tO\ndeath\tO\n(\tO\nin\tO\n67\tO\n%\tO\nor\tO\n90\tO\n%\tO\nof\tO\nanimals\tO\nrespectively\tO\n)\tO\n.\tO\n\nIntravenous\tO\ninjection\tO\nof\tO\nthe\tO\nspecific\tO\nplatelet\tO\n-\tO\nactivating\tO\nfactor\tO\n(\tO\nPAF\tO\n)\tO\nantagonist\tO\nBN\tB-Chemical\n52021\tI-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\n30\tO\nmin\tO\nbefore\tO\nbupivacaine\tB-Chemical\nadministration\tO\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nsuppressed\tO\nboth\tO\nthe\tO\ndecrease\tB-Disease\nof\tI-Disease\nMBP\tI-Disease\nand\tI-Disease\nHR\tI-Disease\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\ndoses\tO\nof\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\nBN\tB-Chemical\n52021\tI-Chemical\ngiven\tO\n30\tO\nmin\tO\nbefore\tO\nor\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nadministered\tO\n5\tO\nmin\tO\nbefore\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninjection\tO\nof\tO\nbupivacaine\tB-Chemical\nwere\tO\nineffective\tO\n.\tO\n\nWhen\tO\nBN\tB-Chemical\n52021\tI-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nwas\tO\ninjected\tO\nimmediately\tO\nafter\tO\nbupivacaine\tB-Chemical\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\na\tO\npartial\tO\nreversion\tO\nof\tO\nthe\tO\ndecrease\tB-Disease\nof\tI-Disease\nMBP\tI-Disease\nand\tI-Disease\nHR\tI-Disease\nwas\tO\nobserved\tO\n,\tO\nwhereas\tO\nthe\tO\ndose\tO\nof\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nwas\tO\nineffective\tO\n.\tO\n\nA\tO\npartial\tO\nrecovery\tO\nof\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\nECG\tO\nalterations\tO\nwas\tO\nobserved\tO\nafter\tO\npretreatment\tO\nof\tO\nthe\tO\nrats\tO\nwith\tO\nBN\tB-Chemical\n52021\tI-Chemical\n.\tO\n\nSince\tO\nthe\tO\nadministration\tO\nof\tO\nBN\tB-Chemical\n52021\tI-Chemical\n,\tO\nat\tO\nall\tO\ndoses\tO\nstudied\tO\n,\tO\ndid\tO\nnot\tO\nalter\tO\nMBP\tO\nand\tO\nHR\tO\nat\tO\nthe\tO\ndoses\tO\nused\tO\n,\tO\nthe\tO\nbulk\tO\nof\tO\nthese\tO\nresults\tO\nclearly\tO\ndemonstrate\tO\na\tO\nprotective\tO\naction\tO\nof\tO\nBN\tB-Chemical\n52021\tI-Chemical\n,\tO\na\tO\nspecific\tO\nantagonist\tO\nof\tO\nPAF\tO\n,\tO\nagainst\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\ncardiovascular\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nThus\tO\n,\tO\nconsistent\tO\nwith\tO\nits\tO\ndirect\tO\neffect\tO\non\tO\nheart\tO\n,\tO\nPAF\tO\nappears\tO\nto\tO\nbe\tO\nimplicated\tO\nin\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\ncardiovascular\tB-Disease\nalterations\tI-Disease\n.\tO\n\nThe\tO\nepidemiology\tO\nof\tO\nthe\tO\nacute\tO\nflank\tB-Disease\npain\tI-Disease\nsyndrome\tO\nfrom\tO\nsuprofen\tB-Chemical\n.\tO\n\nSuprofen\tB-Chemical\n,\tO\na\tO\nnew\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrug\tO\n,\tO\nwas\tO\nmarketed\tO\nin\tO\nearly\tO\n1986\tO\nas\tO\nan\tO\nanalgesic\tO\nagent\tO\n.\tO\n\nUntil\tO\nphysicians\tO\nbegan\tO\nreporting\tO\nan\tO\nunusual\tO\nacute\tO\nflank\tB-Disease\npain\tI-Disease\nsyndrome\tO\nto\tO\nthe\tO\nspontaneous\tO\nreporting\tO\nsystem\tO\n,\tO\n700\tO\n,\tO\n000\tO\npersons\tO\nused\tO\nthe\tO\ndrug\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tO\n\nThrough\tO\nAugust\tO\n1986\tO\n,\tO\na\tO\ntotal\tO\nof\tO\n163\tO\ncases\tO\nof\tO\nthis\tO\nsyndrome\tO\nwere\tO\nreported\tO\n.\tO\n\nTo\tO\nelucidate\tO\nthe\tO\nepidemiology\tO\nof\tO\nthe\tO\nsyndrome\tO\n,\tO\na\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nwas\tO\nperformed\tO\n,\tO\ncomparing\tO\n62\tO\nof\tO\nthe\tO\ncase\tO\npatients\tO\nwho\tO\nhad\tO\nbeen\tO\nreported\tO\nto\tO\nthe\tO\nspontaneous\tO\nreporting\tO\nsystem\tO\nto\tO\n185\tO\nsuprofen\tB-Chemical\n-\tO\nexposed\tO\ncontrol\tO\nsubjects\tO\nwho\tO\ndid\tO\nnot\tO\nhave\tO\nthe\tO\nsyndrome\tO\n.\tO\n\nCase\tO\npatients\tO\nwere\tO\nmore\tO\nlikely\tO\nto\tO\nbe\tO\nmen\tO\n(\tO\nodds\tO\nratio\tO\n,\tO\n3\tO\n.\tO\n8\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n2\tO\n-\tO\n12\tO\n.\tO\n1\tO\n)\tO\n,\tO\nsuffer\tO\nfrom\tO\nhay\tB-Disease\nfever\tI-Disease\nand\tO\nasthma\tB-Disease\n(\tO\nodds\tO\nratio\tO\n,\tO\n3\tO\n.\tO\n4\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n0\tO\n-\tO\n11\tO\n.\tO\n9\tO\n)\tO\n;\tO\nto\tO\nparticipate\tO\nin\tO\nregular\tO\nexercise\tO\n(\tO\nodds\tO\nratio\tO\n,\tO\n5\tO\n.\tO\n9\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n1\tO\n-\tO\n30\tO\n.\tO\n7\tO\n)\tO\n,\tO\nespecially\tO\nin\tO\nthe\tO\nuse\tO\nof\tO\nNautilus\tO\nequipment\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n02\tO\n)\tO\n;\tO\nand\tO\nto\tO\nuse\tO\nalcohol\tB-Chemical\n(\tO\nodds\tO\nratio\tO\n,\tO\n4\tO\n.\tO\n4\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n1\tO\n-\tO\n17\tO\n.\tO\n5\tO\n)\tO\n.\tO\n\nPossible\tO\nrisk\tO\nfactors\tO\nincluded\tO\nyoung\tO\nage\tO\n,\tO\nconcurrent\tO\nuse\tO\nof\tO\nother\tO\nanalgesic\tO\nagents\tO\n(\tO\nespecially\tO\nibuprofen\tB-Chemical\n)\tO\n,\tO\npreexisting\tO\nrenal\tB-Disease\ndisease\tI-Disease\n,\tO\na\tO\nhistory\tO\nof\tO\nkidney\tB-Disease\nstones\tI-Disease\n,\tO\na\tO\nhistory\tO\nof\tO\ngout\tB-Disease\n,\tO\na\tO\nrecent\tO\nincrease\tO\nin\tO\nactivity\tO\n,\tO\na\tO\nrecent\tO\nincrease\tO\nin\tO\nsun\tO\nexposure\tO\n,\tO\nand\tO\nresidence\tO\nin\tO\nthe\tO\nSunbelt\tO\n.\tO\n\nThese\tO\nwere\tO\nfindings\tO\nthat\tO\nwere\tO\nsuggestive\tO\nbut\tO\ndid\tO\nnot\tO\nreach\tO\nconventional\tO\nstatistical\tO\nsignificance\tO\n.\tO\n\nThese\tO\nfindings\tO\nare\tO\nconsistent\tO\nwith\tO\nthe\tO\npostulated\tO\nmechanism\tO\nfor\tO\nthis\tO\nunusual\tO\nsyndrome\tO\n:\tO\nacute\tO\ndiffuse\tO\ncrystallization\tO\nof\tO\nuric\tB-Chemical\nacid\tI-Chemical\nin\tO\nrenal\tO\ntubules\tO\n.\tO\n\nPhlorizin\tB-Chemical\n-\tO\ninduced\tO\nglycosuria\tB-Disease\ndoes\tO\nnot\tO\nprevent\tO\ngentamicin\tB-Chemical\nnephrotoxicity\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nBecause\tO\nrats\tO\nwith\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\n(\tO\nDM\tB-Disease\n)\tO\nhave\tO\na\tO\nhigh\tO\nsolute\tO\ndiuresis\tO\n(\tO\nglycosuria\tB-Disease\nof\tO\n10\tO\nto\tO\n12\tO\ng\tO\n/\tO\nday\tO\n)\tO\n,\tO\nwe\tO\nhave\tO\nsuggested\tO\nthat\tO\nthis\tO\nmay\tO\nin\tO\npart\tO\nbe\tO\nresponsible\tO\nfor\tO\ntheir\tO\nresistance\tO\nto\tO\ngentamicin\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n(\tO\nARF\tB-Disease\n)\tO\n.\tO\n\nThe\tO\nprotection\tO\nfrom\tO\ngentamicin\tB-Chemical\nnephrotoxicity\tB-Disease\nwas\tO\nstudied\tO\nin\tO\nnon\tO\n-\tO\ndiabetic\tB-Disease\nrats\tO\nwith\tO\nchronic\tO\nsolute\tO\ndiuresis\tO\ninduced\tO\nby\tO\nblockage\tO\nof\tO\ntubular\tO\nglucose\tB-Chemical\nreabsorption\tO\nwith\tO\nphlorizin\tB-Chemical\n(\tO\nP\tB-Chemical\n)\tO\n.\tO\n\nDM\tB-Disease\nrats\tO\nwith\tO\nmild\tO\nglycosuria\tB-Disease\n(\tO\nsimilar\tO\nin\tO\ndegree\tO\nto\tO\nthat\tO\nof\tO\nthe\tO\nP\tB-Chemical\ntreated\tO\nanimals\tO\n)\tO\nwere\tO\nalso\tO\nstudied\tO\n.\tO\n\nUnanesthetized\tO\nadult\tO\nfemale\tO\n,\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\ndivided\tO\nin\tO\nfour\tO\ngroups\tO\nand\tO\nstudied\tO\nfor\tO\n15\tO\ndays\tO\n.\tO\n\nGroup\tO\n1\tO\n(\tO\nP\tB-Chemical\nalone\tO\n)\tO\nreceived\tO\nP\tB-Chemical\n,\tO\n360\tO\nmg\tO\n/\tO\nday\tO\n,\tO\nfor\tO\n15\tO\ndays\tO\n;\tO\nGroup\tO\nII\tO\n(\tO\nP\tB-Chemical\n+\tO\ngentamicin\tB-Chemical\n)\tO\n;\tO\nGroup\tO\nIII\tO\n(\tO\ngentamicin\tB-Chemical\nalone\tO\n)\tO\nand\tO\nGroup\tO\nIV\tO\n(\tO\nmild\tO\nDM\tB-Disease\n+\tO\ngentamicin\tB-Chemical\n)\tO\n.\tO\n\nNephrotoxic\tB-Disease\ndoses\tO\n(\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nwt\tO\n/\tO\nday\tO\n)\tO\nof\tO\ngentamicin\tB-Chemical\nwere\tO\ninjected\tO\nduring\tO\nthe\tO\nlast\tO\nnine\tO\ndays\tO\nof\tO\nstudy\tO\nto\tO\nthe\tO\nanimals\tO\nof\tO\ngroups\tO\nII\tO\nto\tO\nIV\tO\n.\tO\n\nIn\tO\nGroup\tO\nI\tO\n,\tO\nP\tB-Chemical\ninduced\tO\na\tO\nmoderate\tO\nand\tO\nstable\tO\nglycosuria\tB-Disease\n(\tO\n3\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\ng\tO\n/\tO\nday\tO\n,\tO\nSE\tO\n)\tO\n,\tO\nand\tO\nno\tO\nfunctional\tO\nor\tO\nmorphologic\tO\nevidence\tO\nof\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\n(\tO\nbaseline\tO\nCCr\tO\n2\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nml\tO\n/\tO\nmin\tO\n,\tO\nundetectable\tO\nlysozymuria\tO\n)\tO\nor\tO\ndamage\tO\n(\tO\ntubular\tB-Disease\nnecrosis\tI-Disease\nscore\tO\n[\tO\nmaximum\tO\n4\tO\n]\tO\n,\tO\nzero\tO\n)\tO\n.\tO\n\nIn\tO\nGroup\tO\nII\tO\n,\tO\nP\tB-Chemical\ndid\tO\nnot\tO\nprevent\tO\ngentamicin\tB-Chemical\n-\tO\nARF\tB-Disease\n(\tO\nmaximal\tO\ndecrease\tO\nin\tO\nCCr\tO\nat\tO\nday\tO\n9\tO\n.\tO\n89\tO\n%\tO\n,\tO\nP\tB-Chemical\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n;\tO\npeak\tO\nlysozymuria\tO\n,\tO\n1863\tO\n+\tO\n/\tO\n-\tO\n321\tO\nmicrograms\tO\n/\tO\nday\tO\n;\tO\nand\tO\ntubular\tB-Disease\nnecrosis\tI-Disease\nscore\tO\n,\tO\n3\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\n)\tO\n.\tO\n\nThese\tO\nvalues\tO\nwere\tO\nnot\tO\ndifferent\tO\nfrom\tO\nthose\tO\nof\tO\nGroup\tO\nIII\tO\n:\tO\nmaximal\tO\ndecrease\tO\nin\tO\nCCr\tO\n73\tO\n%\tO\n(\tO\nP\tB-Chemical\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n;\tO\nlysozymuria\tO\n,\tO\n2147\tO\n+\tO\n/\tO\n-\tO\n701\tO\nmicrograms\tO\n/\tO\nday\tO\n;\tO\ntubular\tB-Disease\nnecrosis\tI-Disease\nscore\tO\n,\tO\n3\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nCatalepsy\tB-Disease\ninduced\tO\nby\tO\ncombinations\tO\nof\tO\nketamine\tB-Chemical\nand\tO\nmorphine\tB-Chemical\n:\tO\npotentiation\tO\n,\tO\nantagonism\tO\n,\tO\ntolerance\tO\nand\tO\ncross\tO\n-\tO\ntolerance\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nPrevious\tO\nstudies\tO\ndemonstrated\tO\nthat\tO\nboth\tO\nketamine\tB-Chemical\nand\tO\nmorphine\tB-Chemical\ninduced\tO\nanalgesia\tB-Disease\nand\tO\ncatalepsy\tB-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nPre\tO\n-\tO\ntreatment\tO\nwith\tO\nketamine\tB-Chemical\nproduced\tO\ncross\tO\n-\tO\ntolerance\tO\nto\tO\nmorphine\tB-Chemical\n,\tO\nwhereas\tO\npretreatment\tO\nwith\tO\nmorphine\tB-Chemical\ndid\tO\nnot\tO\ninduce\tO\ncross\tO\n-\tO\ntolerance\tO\nto\tO\nketamine\tB-Chemical\nbut\tO\nrather\tO\naugmented\tO\nthe\tO\ncataleptic\tB-Disease\nresponse\tO\n;\tO\nthis\tO\naugmentation\tO\nwas\tO\nattributed\tO\nto\tO\nresidual\tO\nmorphine\tB-Chemical\nin\tO\nthe\tO\nbrain\tO\n.\tO\n\nThe\tO\npresent\tO\nstudies\tO\nexplored\tO\nthe\tO\nduration\tO\nof\tO\nthe\tO\nloss\tO\nof\tO\nrighting\tO\nreflex\tO\ninduced\tO\nby\tO\nsub\tO\n-\tO\neffective\tO\ndoses\tO\nof\tO\nketamine\tB-Chemical\nand\tO\nmorphine\tB-Chemical\n,\tO\nadministered\tO\nsimultaneously\tO\n.\tO\n\nThere\tO\nwas\tO\nmutual\tO\npotentiation\tO\nbetween\tO\nsub\tO\n-\tO\neffective\tO\ndoses\tO\nof\tO\nketamine\tB-Chemical\nand\tO\nmorphine\tB-Chemical\n,\tO\nbut\tO\nsub\tO\n-\tO\neffective\tO\ndoses\tO\nof\tO\nketamine\tB-Chemical\npartly\tO\nantagonized\tO\nfully\tO\n-\tO\neffective\tO\ndoses\tO\nof\tO\nmorphine\tB-Chemical\n.\tO\n\nLatency\tO\nto\tO\nthe\tO\nloss\tO\nof\tO\nrighting\tO\nreflex\tO\n,\tO\nrigidity\tB-Disease\nand\tO\nbehavior\tO\non\tO\nrecovery\tO\n,\tO\nreflected\tO\nthe\tO\nrelative\tO\npredominance\tO\nof\tO\nketamine\tB-Chemical\nor\tO\nmorphine\tB-Chemical\nin\tO\neach\tO\ncombination\tO\n.\tO\n\nNaloxone\tB-Chemical\ninhibited\tO\nthe\tO\ninduced\tO\ncataleptic\tB-Disease\neffects\tO\n.\tO\n\nThe\tO\ndegree\tO\nand\tO\ntime\tO\ncourse\tO\nof\tO\ndevelopment\tO\nof\tO\ntolerance\tO\nto\tO\ndaily\tO\nadministration\tO\nof\tO\nsub\tO\n-\tO\neffective\tO\ndose\tO\ncombinations\tO\nof\tO\nketamine\tB-Chemical\nand\tO\nmorphine\tB-Chemical\nwere\tO\nsimilar\tO\n.\tO\n\nRats\tO\n,\tO\ntolerant\tO\nto\tO\nketamine\tB-Chemical\n-\tO\ndominant\tO\ncombinations\tO\n,\tO\nwere\tO\ncross\tO\n-\tO\ntolerant\tO\nto\tO\nboth\tO\ndrugs\tO\n,\tO\nwhile\tO\nthose\tO\ntolerant\tO\nto\tO\nmorphine\tB-Chemical\n-\tO\ndominant\tO\ncombinations\tO\nwere\tO\ncross\tO\n-\tO\ntolerant\tO\nto\tO\nmorphine\tB-Chemical\nbut\tO\nshowed\tO\neither\tO\nno\tO\ncross\tO\n-\tO\ntolerance\tO\nor\tO\nan\tO\naugmented\tO\nresponse\tO\nto\tO\nketamine\tB-Chemical\n.\tO\n\nWhile\tO\nthe\tO\nmutual\tO\npotentiation\tO\n,\tO\nantagonism\tO\nand\tO\ntolerance\tO\nsuggest\tO\ncommon\tO\nmechanisms\tO\nfor\tO\nthe\tO\ninduced\tO\ncatalepsy\tB-Disease\n,\tO\ndifferences\tO\nin\tO\nlatency\tO\n,\tO\nrigidity\tB-Disease\nand\tO\nbehavior\tO\n,\tO\nasymmetry\tO\nof\tO\ncross\tO\n-\tO\ntolerance\tO\nand\tO\na\tO\nwidely\tO\n-\tO\ndifferent\tO\nID50\tO\nfor\tO\nnaloxone\tB-Chemical\nwould\tO\nargue\tO\nagainst\tO\nan\tO\naction\tO\nat\tO\na\tO\nsingle\tO\nopioid\tO\nsite\tO\n.\tO\n\nHydrocortisone\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nhumans\tO\n:\tO\npressor\tO\nresponsiveness\tO\nand\tO\nsympathetic\tO\nfunction\tO\n.\tO\n\nOral\tO\nhydrocortisone\tB-Chemical\nincreases\tO\nblood\tO\npressure\tO\nand\tO\nenhances\tO\npressor\tO\nresponsiveness\tO\nin\tO\nnormal\tO\nhuman\tO\nsubjects\tO\n.\tO\n\nWe\tO\nstudied\tO\nthe\tO\neffects\tO\nof\tO\n1\tO\nweek\tO\nof\tO\noral\tO\nhydrocortisone\tB-Chemical\n(\tO\n200\tO\nmg\tO\n/\tO\nday\tO\n)\tO\non\tO\nblood\tO\npressure\tO\n,\tO\ncardiac\tO\noutput\tO\n,\tO\ntotal\tO\nperipheral\tO\nresistance\tO\n,\tO\nforearm\tO\nvascular\tO\nresistance\tO\n,\tO\nand\tO\nnorepinephrine\tB-Chemical\nspillover\tO\nto\tO\nplasma\tO\nin\tO\neight\tO\nhealthy\tO\nmale\tO\nvolunteers\tO\n.\tO\n\nAlthough\tO\ndiastolic\tO\nblood\tO\npressure\tO\nremained\tO\nunchanged\tO\n,\tO\nsystolic\tO\nblood\tO\npressure\tO\nincreased\tO\nfrom\tO\n119\tO\nto\tO\n135\tO\nmm\tO\nHg\tO\n(\tO\nSED\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n4\tO\n,\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tB-Disease\ncardiac\tI-Disease\noutput\tI-Disease\n(\tO\n5\tO\n.\tO\n85\tO\n-\tO\n7\tO\n.\tO\n73\tO\nl\tO\n/\tO\nmin\tO\n,\tO\nSED\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n46\tO\n,\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nTotal\tO\nperipheral\tO\nvascular\tO\nresistance\tO\nfell\tO\nfrom\tO\n15\tO\n.\tO\n1\tO\nto\tO\n12\tO\n.\tO\n2\tO\nmm\tO\nHg\tO\n/\tO\nl\tO\n/\tO\nmin\tO\n(\tO\nSED\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n03\tO\n,\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nResting\tO\nforearm\tO\nvascular\tO\nresistance\tO\nremained\tO\nunchanged\tO\n,\tO\nbut\tO\nthe\tO\nreflex\tO\nresponse\tO\nto\tO\nthe\tO\ncold\tO\npressor\tO\ntest\tO\nwas\tO\naccentuated\tO\n,\tO\nthe\tO\nrise\tO\nin\tO\nresistance\tO\nincreasing\tO\nfrom\tO\n10\tO\n.\tO\n5\tO\nmm\tO\nHg\tO\n/\tO\nml\tO\n/\tO\n100\tO\nml\tO\n/\tO\nmin\tO\n(\tO\nR\tO\nunits\tO\n)\tO\nbefore\tO\ntreatment\tO\nto\tO\n32\tO\n.\tO\n6\tO\nR\tO\nunits\tO\nafter\tO\ntreatment\tO\n(\tO\nSED\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n4\tO\n,\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nThe\tO\nrise\tO\nin\tO\nforearm\tO\nvascular\tO\nresistance\tO\naccompanying\tO\nintra\tO\n-\tO\narterial\tO\nnorepinephrine\tB-Chemical\n(\tO\n25\tO\n,\tO\n50\tO\n,\tO\nand\tO\n100\tO\nng\tO\n/\tO\nmin\tO\n)\tO\nwas\tO\nalso\tO\nsignificantly\tO\ngreater\tO\nafter\tO\nhydrocortisone\tB-Chemical\n,\tO\nincreasing\tO\nfrom\tO\nan\tO\naverage\tO\nof\tO\n14\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n4\tO\nR\tO\nunits\tO\nbefore\tO\ntreatment\tO\nto\tO\n35\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n5\tO\nR\tO\nunits\tO\nafter\tO\nhydrocortisone\tB-Chemical\n(\tO\nSED\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n0\tO\n,\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nA\tO\nshift\tO\nto\tO\nthe\tO\nleft\tO\nin\tO\nthe\tO\ndose\tO\n-\tO\nresponse\tO\nrelation\tO\nand\tO\nfall\tO\nin\tO\nthreshold\tO\nsuggested\tO\nincreased\tO\nsensitivity\tO\nto\tO\nnorepinephrine\tB-Chemical\nafter\tO\ntreatment\tO\n.\tO\n\nMeasurement\tO\nof\tO\nresting\tO\nnorepinephrine\tB-Chemical\nspillover\tO\nrate\tO\nto\tO\nplasma\tO\nand\tO\nnorepinephrine\tB-Chemical\nuptake\tO\nindicated\tO\nthat\tO\noverall\tO\nresting\tO\nsympathetic\tO\nnervous\tO\nsystem\tO\nactivity\tO\nwas\tO\nnot\tO\nincreased\tO\n.\tO\n\nThe\tO\nrise\tB-Disease\nin\tI-Disease\nresting\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nwith\tO\nhydrocortisone\tB-Chemical\nis\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tB-Disease\ncardiac\tI-Disease\noutput\tI-Disease\n(\tO\npresumably\tO\ndue\tO\nto\tO\nincreased\tO\nblood\tO\nvolume\tO\n)\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nNeuromuscular\tB-Disease\nblockade\tI-Disease\nwith\tO\nmagnesium\tB-Chemical\nsulfate\tI-Chemical\nand\tO\nnifedipine\tB-Chemical\n.\tO\n\nA\tO\npatient\tO\nwho\tO\nreceived\tO\ntocolysis\tO\nwith\tO\nnifedipine\tB-Chemical\ndeveloped\tO\nneuromuscular\tB-Disease\nblockade\tI-Disease\nafter\tO\n500\tO\nmg\tO\nof\tO\nmagnesium\tB-Chemical\nsulfate\tI-Chemical\nwas\tO\nadministered\tO\n.\tO\n\nThis\tO\nreaction\tO\ndemonstrates\tO\nthat\tO\nnifedipine\tB-Chemical\ncan\tO\nseriously\tO\npotentiate\tO\nthe\tO\ntoxicity\tB-Disease\nof\tO\nmagnesium\tB-Chemical\n.\tO\n\nCaution\tO\nshould\tO\nbe\tO\nexercised\tO\nwhen\tO\nthese\tO\ntwo\tO\ntocolytics\tO\nare\tO\ncombined\tO\n.\tO\n\nChronic\tO\ncarbamazepine\tB-Chemical\ninhibits\tO\nthe\tO\ndevelopment\tO\nof\tO\nlocal\tO\nanesthetic\tO\nseizures\tB-Disease\nkindled\tO\nby\tO\ncocaine\tB-Chemical\nand\tO\nlidocaine\tB-Chemical\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ncarbamazepine\tB-Chemical\n(\tO\nCBZ\tB-Chemical\n)\tO\ntreatment\tO\non\tO\nlocal\tO\nanesthetic\tO\n-\tO\nkindled\tO\nseizures\tB-Disease\nand\tO\nlethality\tO\nwere\tO\nevaluated\tO\nin\tO\ndifferent\tO\nstages\tO\nof\tO\nthe\tO\nkindling\tO\nprocess\tO\nand\tO\nunder\tO\ndifferent\tO\nmethods\tO\nof\tO\nCBZ\tB-Chemical\nadministration\tO\n.\tO\n\nChronic\tO\noral\tO\nCBZ\tB-Chemical\ninhibited\tO\nthe\tO\ndevelopment\tO\nof\tO\nboth\tO\nlidocaine\tB-Chemical\n-\tO\nand\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n,\tO\nbut\tO\nhad\tO\nlittle\tO\neffect\tO\non\tO\nthe\tO\nfully\tO\ndeveloped\tO\nlocal\tO\nanesthetic\tO\nseizures\tB-Disease\n.\tO\n\nChronic\tO\nCBZ\tB-Chemical\nalso\tO\ndecreased\tO\nthe\tO\nincidence\tO\nof\tO\nseizure\tB-Disease\n-\tO\nrelated\tO\nmortality\tO\nin\tO\nthe\tO\ncocaine\tB-Chemical\n-\tO\ninjected\tO\nrats\tO\n.\tO\n\nAcute\tO\nCBZ\tB-Chemical\nover\tO\na\tO\nrange\tO\nof\tO\ndoses\tO\n(\tO\n15\tO\n-\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nhad\tO\nno\tO\neffect\tO\non\tO\ncompleted\tO\nlidocaine\tB-Chemical\n-\tO\nkindled\tO\nor\tO\nacute\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nRepeated\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tO\nof\tO\nCBZ\tB-Chemical\n(\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nalso\tO\nwas\tO\nwithout\tO\neffect\tO\non\tO\nthe\tO\ndevelopment\tO\nof\tO\nlidocaine\tB-Chemical\n-\tO\nor\tO\ncocaine\tB-Chemical\n-\tO\nkindled\tO\nseizures\tB-Disease\n.\tO\n\nThe\tO\ndifferential\tO\neffects\tO\nof\tO\nCBZ\tB-Chemical\ndepending\tO\nupon\tO\nstage\tO\nof\tO\nseizure\tB-Disease\ndevelopment\tO\nsuggest\tO\nthat\tO\ndistinct\tO\nmechanisms\tO\nunderlie\tO\nthe\tO\ndevelopment\tO\nversus\tO\nmaintenance\tO\nof\tO\nlocal\tO\nanesthetic\tO\n-\tO\nkindled\tO\nseizures\tB-Disease\n.\tO\n\nThe\tO\neffectiveness\tO\nof\tO\nchronic\tO\nbut\tO\nnot\tO\nrepeated\tO\n,\tO\nintermittent\tO\ninjections\tO\nof\tO\nCBZ\tB-Chemical\nsuggests\tO\nthat\tO\ndifferent\tO\nbiochemical\tO\nconsequences\tO\nresult\tO\nfrom\tO\nthe\tO\ndifferent\tO\ntreatment\tO\nregimens\tO\n.\tO\n\nThe\tO\npossible\tO\nutility\tO\nof\tO\nchronic\tO\nCBZ\tB-Chemical\nin\tO\npreventing\tO\nthe\tO\ndevelopment\tO\nof\tO\ntoxic\tO\nside\tO\neffects\tO\nin\tO\nhuman\tO\ncocaine\tB-Chemical\nusers\tO\nis\tO\nsuggested\tO\nby\tO\nthese\tO\ndata\tO\n,\tO\nbut\tO\nremains\tO\nto\tO\nbe\tO\ndirectly\tO\nevaluated\tO\n.\tO\n\nMagnetic\tO\nresonance\tO\nimaging\tO\nof\tO\ncerebral\tO\nvenous\tB-Disease\nthrombosis\tI-Disease\nsecondary\tO\nto\tO\n\"\tO\nlow\tO\n-\tO\ndose\tO\n\"\tO\nbirth\tO\ncontrol\tO\npills\tO\n.\tO\n\nThe\tO\nclinical\tO\nand\tO\nradiographic\tO\nfeatures\tO\nof\tO\ncerebral\tO\ndeep\tB-Disease\nvenous\tI-Disease\nthrombosis\tI-Disease\nin\tO\na\tO\n21\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwhite\tO\nwoman\tO\nare\tO\npresented\tO\n.\tO\n\nThis\tO\nnulliparous\tO\npatient\tO\npresented\tO\nwith\tO\nrelatively\tO\nmild\tO\nclinical\tO\nsymptoms\tO\nand\tO\nprogressing\tO\nmental\tO\nstatus\tO\nchanges\tO\n.\tO\n\nThe\tO\nonly\tO\nknown\tO\nrisk\tO\nfactor\tO\nwas\tO\n\"\tO\nlow\tO\n-\tO\ndose\tO\n\"\tO\noral\tB-Chemical\ncontraceptive\tI-Chemical\npills\tO\n.\tO\n\nThe\tO\nmagnetic\tO\nresonance\tO\nimage\tO\n(\tO\nMRI\tO\n)\tO\nshowed\tO\nincreased\tO\nsignal\tO\nintensity\tO\nfrom\tO\nthe\tO\ninternal\tO\ncerebral\tO\nveins\tO\n,\tO\nvein\tO\nof\tO\nGalen\tO\n,\tO\nand\tO\nstraight\tO\nsinus\tO\n.\tO\n\nThe\tO\ndiagnosis\tO\nwas\tO\nconfirmed\tO\nby\tO\narterial\tO\nangiography\tO\n.\tO\n\nBeta\tO\n-\tO\n2\tO\n-\tO\nadrenoceptor\tO\n-\tO\nmediated\tO\nhypokalemia\tB-Disease\nand\tO\nits\tO\nabolishment\tO\nby\tO\noxprenolol\tB-Chemical\n.\tO\n\nThe\tO\ntime\tO\ncourse\tO\nand\tO\nconcentration\tO\n-\tO\neffect\tO\nrelationship\tO\nof\tO\nterbutaline\tB-Chemical\n-\tO\ninduced\tO\nhypokalemia\tB-Disease\nwas\tO\nstudied\tO\n,\tO\nusing\tO\ncomputer\tO\n-\tO\naided\tO\npharmacokinetic\tO\n-\tO\ndynamic\tO\nmodeling\tO\n.\tO\n\nSubsequently\tO\nwe\tO\ninvestigated\tO\nthe\tO\nefficacy\tO\nof\tO\noxprenolol\tB-Chemical\nin\tO\nantagonizing\tO\nsuch\tO\nhypokalemia\tB-Disease\n,\tO\ntogether\tO\nwith\tO\nthe\tO\npharmacokinetic\tO\ninteraction\tO\nbetween\tO\nboth\tO\ndrugs\tO\n.\tO\n\nSix\tO\nhealthy\tO\nsubjects\tO\nwere\tO\ngiven\tO\na\tO\n0\tO\n.\tO\n5\tO\nmg\tO\nsubcutaneous\tO\ndose\tO\nof\tO\nterbutaline\tB-Chemical\non\tO\ntwo\tO\noccasions\tO\n:\tO\n1\tO\nhour\tO\nafter\tO\noral\tO\nadministration\tO\nof\tO\na\tO\nplacebo\tO\nand\tO\n1\tO\nhour\tO\nafter\tO\n80\tO\nmg\tO\noxprenolol\tB-Chemical\norally\tO\n.\tO\n\nIn\tO\nthe\tO\n7\tO\n-\tO\nhour\tO\nperiod\tO\nafter\tO\nterbutaline\tB-Chemical\nadministration\tO\n,\tO\nplasma\tO\nsamples\tO\nwere\tO\ntaken\tO\nfor\tO\ndetermination\tO\nof\tO\nplasma\tO\npotassium\tB-Chemical\nlevels\tO\nand\tO\ndrug\tO\nconcentrations\tO\n.\tO\n\nThe\tO\nsigmoid\tO\nEmax\tO\nmodel\tO\noffered\tO\na\tO\ngood\tO\ndescription\tO\nof\tO\nthe\tO\nrelation\tO\nbetween\tO\nterbutaline\tB-Chemical\nconcentrations\tO\nand\tO\npotassium\tB-Chemical\neffects\tO\n.\tO\n\nOxprenolol\tB-Chemical\ncaused\tO\ndecreases\tO\nof\tO\n65\tO\n%\tO\nand\tO\n56\tO\n%\tO\nof\tO\nterbutaline\tB-Chemical\nvolume\tO\nof\tO\ndistribution\tO\nand\tO\nclearance\tO\n,\tO\nrespectively\tO\n,\tO\nand\tO\nan\tO\nincrease\tO\nof\tO\n130\tO\n%\tO\nof\tO\nits\tO\nAUC\tO\n.\tO\n\nIn\tO\nspite\tO\nof\tO\nhigher\tO\nterbutaline\tB-Chemical\nconcentrations\tO\nafter\tO\noxprenolol\tB-Chemical\npretreatment\tO\n,\tO\nthe\tO\nhypokalemia\tB-Disease\nwas\tO\nalmost\tO\ncompletely\tO\nantagonized\tO\nby\tO\nthe\tO\nbeta\tO\n2\tO\n-\tO\nblocking\tO\naction\tO\n.\tO\n\nA\tO\ndystonia\tB-Disease\n-\tO\nlike\tO\nsyndrome\tO\nafter\tO\nneuropeptide\tO\n(\tO\nMSH\tB-Chemical\n/\tO\nACTH\tB-Chemical\n)\tO\nstimulation\tO\nof\tO\nthe\tO\nrat\tO\nlocus\tO\nceruleus\tO\n.\tO\n\nThe\tO\nmovement\tB-Disease\ndisorder\tI-Disease\ninvestigated\tO\nin\tO\nthese\tO\nstudies\tO\nhas\tO\nsome\tO\nfeatures\tO\nin\tO\ncommon\tO\nwith\tO\nhuman\tO\nidiopathic\tO\ndystonia\tB-Disease\n,\tO\nand\tO\ninformation\tO\nobtained\tO\nin\tO\nthese\tO\nstudies\tO\nmay\tO\nbe\tO\nof\tO\npotential\tO\nclinical\tO\nbenefit\tO\n.\tO\n\nThe\tO\npresent\tO\nexperimental\tO\nresults\tO\nindicated\tO\nthat\tO\npeptidergic\tO\nstimulation\tO\nof\tO\nthe\tO\nLC\tO\nresulted\tO\nin\tO\na\tO\nNE\tO\n-\tO\nmediated\tO\ninhibition\tO\nof\tO\ncerebellar\tO\nPurkinje\tO\ncells\tO\nlocated\tO\nat\tO\nterminals\tO\nof\tO\nthe\tO\nceruleo\tO\n-\tO\ncerebellar\tO\npathway\tO\n.\tO\n\nHowever\tO\n,\tO\nit\tO\nis\tO\nnot\tO\ncertain\tO\nas\tO\nto\tO\nthe\tO\nfollowing\tO\n:\tO\n(\tO\na\tO\n)\tO\nwhat\tO\nreceptors\tO\nwere\tO\nstimulated\tO\nby\tO\nthe\tO\nACTH\tB-Chemical\nN\tO\n-\tO\nterminal\tO\nfragments\tO\nat\tO\nthe\tO\nLC\tO\nthat\tO\nresulted\tO\nin\tO\nthis\tO\ndisorder\tO\n;\tO\n(\tO\nb\tO\n)\tO\nwhether\tO\nNE\tO\n,\tO\nreleased\tO\nonto\tO\nPurkinje\tO\ncell\tO\nsynapses\tO\nlocated\tO\nat\tO\nterminals\tO\nof\tO\nthe\tO\nceruleo\tO\n-\tO\ncerebellar\tO\npathway\tO\n,\tO\ndid\tO\nindeed\tO\ncause\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\ndepression\tB-Disease\nat\tO\nPurkinje\tO\ncell\tO\nsynapses\tO\n(\tO\npreviously\tO\ndescribed\tO\nby\tO\nothers\tO\n)\tO\nthat\tO\nresulted\tO\nin\tO\nthe\tO\nlong\tO\nduration\tO\nof\tO\nthe\tO\nmovement\tB-Disease\ndisorder\tI-Disease\n;\tO\n(\tO\nc\tO\n)\tO\nwhether\tO\nthe\tO\ninhibition\tO\nof\tO\ninhibitory\tO\nPurkinje\tO\ncells\tO\nresulted\tO\nin\tO\ndisinhibition\tO\nor\tO\nincreased\tO\nexcitability\tO\nof\tO\nthe\tO\nunilateral\tO\ncerebellar\tO\nfastigial\tO\nor\tO\ninterpositus\tO\nnuclei\tO\n,\tO\nthe\tO\noutput\tO\ntargets\tO\nof\tO\nthe\tO\nPurkinje\tO\ncell\tO\naxons\tO\n,\tO\nthat\tO\nmay\tO\nhave\tO\nbeen\tO\nan\tO\nimportant\tO\ncontributing\tO\nfactor\tO\nto\tO\nthis\tO\ndisorder\tO\n.\tO\n\nThese\tO\nquestions\tO\nare\tO\ncurrently\tO\nbeing\tO\ninvestigated\tO\n.\tO\n\nEnhanced\tO\nstimulus\tO\n-\tO\ninduced\tO\nneurotransmitter\tO\noverflow\tO\nin\tO\nepinephrine\tB-Chemical\n-\tO\ninduced\tO\nhypertensive\tB-Disease\nrats\tO\nis\tO\nnot\tO\nmediated\tO\nby\tO\nprejunctional\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\nactivation\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nexamines\tO\nthe\tO\neffect\tO\nof\tO\n6\tO\n-\tO\nday\tO\nepinephrine\tB-Chemical\ntreatment\tO\n(\tO\n100\tO\nmicrograms\tO\n/\tO\nkg\tO\nper\tO\nh\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\non\tO\nstimulus\tO\n-\tO\ninduced\tO\n(\tO\n1\tO\nHz\tO\n)\tO\nendogenous\tO\nneurotransmitter\tO\noverflow\tO\nfrom\tO\nthe\tO\nisolated\tO\nperfused\tO\nkidney\tO\nof\tO\nvehicle\tO\n-\tO\nand\tO\nepinephrine\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nRenal\tO\ncatecholamine\tB-Chemical\nstores\tO\nand\tO\nstimulus\tO\n-\tO\ninduced\tO\noverflow\tO\nin\tO\nthe\tO\nvehicle\tO\n-\tO\ntreated\tO\ngroup\tO\nconsisted\tO\nof\tO\nnorepinephrine\tB-Chemical\nonly\tO\n.\tO\n\nHowever\tO\n,\tO\nepinephrine\tB-Chemical\ntreatment\tO\nresulted\tO\nin\tO\nthe\tO\nincorporation\tO\nof\tO\nepinephrine\tB-Chemical\ninto\tO\nrenal\tO\ncatecholamine\tB-Chemical\nstores\tO\nsuch\tO\nthat\tO\napproximately\tO\n40\tO\n%\tO\nof\tO\nthe\tO\ncatecholamine\tB-Chemical\npresent\tO\nwas\tO\nepinephrine\tB-Chemical\nwhile\tO\nthe\tO\nnorepinephrine\tB-Chemical\ncontent\tO\nwas\tO\nreduced\tO\nby\tO\na\tO\nsimilar\tO\ndegree\tO\n.\tO\n\nTotal\tO\ntissue\tO\ncatecholamine\tB-Chemical\ncontent\tO\nof\tO\nthe\tO\nkidney\tO\non\tO\na\tO\nmolar\tO\nbasis\tO\nwas\tO\nunchanged\tO\n.\tO\n\nStimulus\tO\n-\tO\ninduced\tO\nfractional\tO\noverflow\tO\nof\tO\nneurotransmitter\tO\nfrom\tO\nthe\tO\nepinephrine\tB-Chemical\n-\tO\ntreated\tO\nkidneys\tO\nwas\tO\napproximately\tO\ntwice\tO\nnormal\tO\nand\tO\nconsisted\tO\nof\tO\nboth\tO\nnorepinephrine\tB-Chemical\nand\tO\nepinephrine\tB-Chemical\nin\tO\nproportions\tO\nsimilar\tO\nto\tO\nthose\tO\nfound\tO\nin\tO\nthe\tO\nkidney\tO\n.\tO\n\nThis\tO\ndifference\tO\nin\tO\nfractional\tO\noverflow\tO\nbetween\tO\ngroups\tO\nwas\tO\nnot\tO\naffected\tO\nby\tO\nneuronal\tO\nand\tO\nextraneuronal\tO\nuptake\tO\nblockade\tO\n.\tO\n\nPropranolol\tB-Chemical\nhad\tO\nno\tO\neffect\tO\non\tO\nstimulus\tO\n-\tO\ninduced\tO\noverflow\tO\nin\tO\neither\tO\ngroup\tO\n.\tO\n\nPhentolamine\tB-Chemical\nincreased\tO\nstimulus\tO\n-\tO\ninduced\tO\noverflow\tO\nin\tO\nboth\tO\ngroups\tO\nalthough\tO\nthe\tO\nincrement\tO\nin\tO\noverflow\tO\nwas\tO\ngreater\tO\nin\tO\nthe\tO\nepinephrine\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nchronic\tO\nepinephrine\tB-Chemical\ntreatment\tO\nresults\tO\nin\tO\nenhanced\tO\nfractional\tO\nneurotransmitter\tO\noverflow\tO\n.\tO\n\nHowever\tO\n,\tO\nneither\tO\nalterations\tO\nin\tO\nprejunctional\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\ninfluences\tO\nnor\tO\nalterations\tO\nin\tO\nneuronal\tO\nand\tO\nextraneuronal\tO\nuptake\tO\nmechanisms\tO\nappear\tO\nto\tO\nbe\tO\nresponsible\tO\nfor\tO\nthis\tO\nalteration\tO\n.\tO\n\nFurthermore\tO\n,\tO\ndata\tO\nobtained\tO\nwith\tO\nphentolamine\tB-Chemical\nalone\tO\ndo\tO\nnot\tO\nsuggest\tO\nalpha\tO\n-\tO\nadrenoceptor\tO\ndesensitization\tO\nas\tO\nthe\tO\ncause\tO\nof\tO\nthe\tO\nenhanced\tO\nneurotransmitter\tO\noverflow\tO\nafter\tO\nepinephrine\tB-Chemical\ntreatment\tO\n.\tO\n\nGABA\tB-Chemical\ninvolvement\tO\nin\tO\nnaloxone\tB-Chemical\ninduced\tO\nreversal\tO\nof\tO\nrespiratory\tB-Disease\nparalysis\tI-Disease\nproduced\tO\nby\tO\nthiopental\tB-Chemical\n.\tO\n\nNo\tO\nagent\tO\nis\tO\nyet\tO\navailable\tO\nto\tO\nreverse\tO\nrespiratory\tB-Disease\nparalysis\tI-Disease\nproduced\tO\nby\tO\nCNS\tO\ndepressants\tO\n,\tO\nsuch\tO\nas\tO\ngeneral\tO\nanesthetics\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\nnaloxone\tB-Chemical\nreversed\tO\nrespiratory\tB-Disease\nparalysis\tI-Disease\ninduced\tO\nby\tO\nthiopental\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\n25\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\nv\tO\n.\tO\nthiopental\tB-Chemical\nproduced\tO\nanesthesia\tO\nwithout\tO\naltering\tO\nrespiratory\tO\nrate\tO\n,\tO\nincreased\tO\nGABA\tB-Chemical\n,\tO\ndecreased\tO\nglutamate\tB-Chemical\n,\tO\nand\tO\nhad\tO\nno\tO\neffect\tO\non\tO\naspartate\tB-Chemical\nor\tO\nglycine\tB-Chemical\nlevels\tO\ncompared\tO\nto\tO\ncontrols\tO\nin\tO\nrat\tO\ncortex\tO\nand\tO\nbrain\tO\nstem\tO\n.\tO\n\nPretreatment\tO\nof\tO\nrats\tO\nwith\tO\nthiosemicarbazide\tB-Chemical\nfor\tO\n30\tO\nminutes\tO\nabolished\tO\nthe\tO\nanesthetic\tO\naction\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\nrespiratory\tO\ndepressant\tO\naction\tO\nof\tO\nthiopental\tB-Chemical\n.\tO\n\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\nv\tO\n.\tO\nthiopental\tB-Chemical\nproduced\tO\nrespiratory\tB-Disease\narrest\tI-Disease\nwith\tO\nfurther\tO\nincrease\tO\nin\tO\nGABA\tB-Chemical\nand\tO\ndecrease\tO\nin\tO\nglutamate\tB-Chemical\nagain\tO\nin\tO\ncortex\tO\nand\tO\nbrain\tO\nstem\tO\nwithout\tO\naffecting\tO\nany\tO\nof\tO\nthe\tO\namino\tB-Chemical\nacids\tI-Chemical\nstudied\tO\nin\tO\nfour\tO\nregions\tO\nof\tO\nrat\tO\nbrain\tO\n.\tO\n\nNaloxone\tB-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nreversed\tO\nrespiratory\tB-Disease\nparalysis\tI-Disease\n,\tO\nglutamate\tB-Chemical\nand\tO\nGABA\tB-Chemical\nlevels\tO\nto\tO\ncontrol\tO\nvalues\tO\nin\tO\nbrain\tO\nstem\tO\nand\tO\ncortex\tO\nwith\tO\nno\tO\nchanges\tO\nin\tO\ncaudate\tO\nor\tO\ncerebellum\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nnaloxone\tB-Chemical\nreverses\tO\nrespiratory\tB-Disease\nparalysis\tI-Disease\nproduced\tO\nby\tO\nthiopental\tB-Chemical\nand\tO\ninvolves\tO\nGABA\tB-Chemical\nin\tO\nits\tO\naction\tO\n.\tO\n\nDiazepam\tB-Chemical\nfacilitates\tO\nreflex\tO\nbradycardia\tB-Disease\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ndiazepam\tB-Chemical\non\tO\ncardiovascular\tO\nfunction\tO\nwere\tO\nassessed\tO\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nIntravenous\tO\nadministration\tO\nof\tO\ndiazepam\tB-Chemical\n(\tO\n1\tO\n-\tO\n30\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\n)\tO\nproduced\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\ndecrease\tO\nin\tO\nboth\tO\nthe\tO\nmean\tO\narterial\tO\npressure\tO\nand\tO\nthe\tO\nheart\tO\nrate\tO\n.\tO\n\nAlso\tO\n,\tO\nreflex\tO\nbradycardia\tB-Disease\nwas\tO\nproduced\tO\nin\tO\nrats\tO\nby\tO\nintravenous\tO\ninfusion\tO\nof\tO\nadrenaline\tB-Chemical\n(\tO\n1\tO\n.\tO\n25\tO\n-\tO\n2\tO\n.\tO\n5\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nIntravenous\tO\npretreatment\tO\nof\tO\nthe\tO\nrats\tO\nwith\tO\ndiazepam\tB-Chemical\n,\tO\nalthough\tO\ncausing\tO\nno\tO\nchange\tO\nin\tO\nthe\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\npressor\tO\neffect\tO\n,\tO\ndid\tO\nenhance\tO\nthe\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\nreflex\tO\nbradycardia\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\ndiazepam\tB-Chemical\nenhancement\tO\nof\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\nreflex\tO\nbradycardia\tB-Disease\nwas\tO\nantagonized\tO\nby\tO\npretreatment\tO\nof\tO\nrats\tO\nwith\tO\nan\tO\nintravenous\tO\ndose\tO\nof\tO\npicrotoxin\tB-Chemical\n(\tO\nan\tO\nagent\tO\nblocks\tO\nchloride\tB-Chemical\nchannels\tO\nby\tO\nbinding\tO\nto\tO\nsites\tO\nassociated\tO\nwith\tO\nthe\tO\nbenzodiazepine\tB-Chemical\n-\tO\nGABA\tB-Chemical\n-\tO\nchloride\tB-Chemical\nchannel\tO\nmacromolecular\tO\ncomplex\tO\n)\tO\n.\tO\n\nThe\tO\ndata\tO\nindicate\tO\nthat\tO\ndiazepam\tB-Chemical\nacts\tO\nthrough\tO\nthe\tO\nbenzodiazepine\tB-Chemical\n-\tO\nGABA\tB-Chemical\n-\tO\nchloride\tB-Chemical\nchannel\tO\nmacromolecular\tO\ncomplex\tO\nwithin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\nto\tO\nfacilitate\tO\nreflex\tO\nbradycardia\tB-Disease\nmediated\tO\nthrough\tO\nbaroreceptor\tO\nreflexes\tO\nin\tO\nresponse\tO\nto\tO\nan\tO\nacute\tO\nincrease\tO\nin\tO\narterial\tO\npressure\tO\n.\tO\n\nInitial\tO\npotassium\tB-Chemical\nloss\tO\nand\tO\nhypokalaemia\tB-Disease\nduring\tO\nchlorthalidone\tB-Chemical\nadministration\tO\nin\tO\npatients\tO\nwith\tO\nessential\tO\nhypertension\tB-Disease\n:\tO\nthe\tO\ninfluence\tO\nof\tO\ndietary\tO\nsodium\tB-Chemical\nrestriction\tO\n.\tO\n\nTo\tO\ninvestigate\tO\nthe\tO\ninitial\tO\npotassium\tB-Chemical\nloss\tO\nand\tO\ndevelopment\tO\nof\tO\nhypokalaemia\tB-Disease\nduring\tO\nthe\tO\nadministration\tO\nof\tO\nan\tO\noral\tO\ndiuretic\tO\n,\tO\nmetabolic\tO\nbalance\tO\nstudies\tO\nwere\tO\nperformed\tO\nin\tO\nten\tO\npatients\tO\nwith\tO\nessential\tO\nhypertension\tB-Disease\nwho\tO\nhad\tO\nshown\tO\nhypokalaemia\tB-Disease\nunder\tO\nprior\tO\noral\tO\ndiuretic\tO\ntreatment\tO\n.\tO\n\nChlorthalidone\tB-Chemical\n(\tO\n50\tO\nmg\tO\ndaily\tO\n)\tO\nwas\tO\ngiven\tO\nfor\tO\n14\tO\ndays\tO\n.\tO\n\nSix\tO\npatients\tO\nreceived\tO\na\tO\nnormal\tO\n-\tO\nsodium\tB-Chemical\ndiet\tO\nand\tO\nfour\tO\na\tO\nlow\tO\n-\tO\nsodium\tB-Chemical\n(\tO\n17\tO\nmmol\tO\n/\tO\nday\tO\n)\tO\ndiet\tO\n.\tO\n\nAll\tO\npatients\tO\nhad\tO\na\tO\nnormal\tO\ninitial\tO\ntotal\tO\nbody\tO\npotassium\tB-Chemical\n(\tO\n40K\tO\n)\tO\n.\tO\n\nThe\tO\nelectrolyte\tO\nbalances\tO\n,\tO\nweight\tO\n,\tO\nbromide\tO\nspace\tO\n,\tO\nplasma\tO\nrenin\tO\nactivity\tO\n,\tO\nand\tO\naldosterone\tB-Chemical\nsecretion\tO\nrate\tO\nwere\tO\nmeasured\tO\n.\tO\n\nIn\tO\nboth\tO\ngroups\tO\na\tO\npotassium\tB-Chemical\ndeficit\tO\ndeveloped\tO\n,\tO\nwith\tO\nproportionally\tO\nlarger\tO\nlosses\tO\nfrom\tO\nthe\tO\nextracellular\tO\nthan\tO\nfrom\tO\nthe\tO\nintracellular\tO\ncompartment\tO\n.\tO\n\nIn\tO\nthe\tO\nnormal\tO\n-\tO\nsodium\tB-Chemical\ngroup\tO\nthe\tO\nhighest\tO\nmean\tO\npotassium\tB-Chemical\ndeficit\tO\nwas\tO\n176\tO\nmmol\tO\non\tO\nday\tO\n9\tO\n,\tO\nafter\tO\nwhich\tO\nsome\tO\npotassium\tB-Chemical\nwas\tO\nregained\tO\n;\tO\nin\tO\nthe\tO\nlow\tO\n-\tO\nsodium\tB-Chemical\ngroup\tO\nthe\tO\nhighest\tO\ndeficit\tO\nwas\tO\n276\tO\nmmol\tO\non\tO\nday\tO\n13\tO\n.\tO\n\nThe\tO\nnormal\tO\n-\tO\nsodium\tB-Chemical\ngroup\tO\nshowed\tO\nan\tO\nimmediate\tO\nbut\tO\ntemporary\tO\nrise\tO\nof\tO\nthe\tO\nrenin\tO\nand\tO\naldosterone\tB-Chemical\nlevels\tO\n;\tO\nin\tO\nthe\tO\nlow\tO\n-\tO\nsodium\tB-Chemical\ngroup\tO\nrenin\tO\nand\tO\naldosterone\tB-Chemical\nincreased\tO\nmore\tO\nslowly\tO\nbut\tO\nremained\tO\nelevated\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\ndietary\tO\nsodium\tB-Chemical\nrestriction\tO\nincreases\tO\ndiuretic\tO\n-\tO\ninduced\tO\npotassium\tB-Chemical\nloss\tO\n,\tO\npresumably\tO\nby\tO\nan\tO\nincreased\tO\nactivity\tO\nof\tO\nthe\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\n-\tO\naldosterone\tB-Chemical\nsystem\tO\n,\tO\nwhile\tO\nsodium\tB-Chemical\ndelivery\tO\nto\tO\nthe\tO\ndistal\tO\nrenal\tO\ntubules\tO\nremains\tO\nsufficiently\tO\nhigh\tO\nto\tO\nallow\tO\nincreased\tO\npotassium\tB-Chemical\nsecretion\tO\n.\tO\n\nReversal\tO\nof\tO\nneuroleptic\tO\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nby\tO\nnovel\tO\naryl\tB-Chemical\n-\tI-Chemical\npiperazine\tI-Chemical\nanxiolytic\tO\ndrugs\tO\n.\tO\n\nThe\tO\nnovel\tO\nanxiolytic\tO\ndrug\tO\n,\tO\nbuspirone\tB-Chemical\n,\tO\nreverses\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\n.\tO\n\nA\tO\nseries\tO\nof\tO\naryl\tB-Chemical\n-\tI-Chemical\npiperazine\tI-Chemical\nanalogues\tO\nof\tO\nbuspirone\tB-Chemical\nand\tO\nother\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptaminergic\tI-Chemical\nagonists\tI-Chemical\nwere\tO\ntested\tO\nfor\tO\ntheir\tO\nability\tO\nto\tO\nreverse\tO\nhaloperidol\tB-Chemical\ninduced\tO\ncatalepsy\tB-Disease\n.\tO\n\nThose\tO\ndrugs\tO\nwith\tO\nstrong\tO\naffinity\tO\nfor\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptamine1a\tI-Chemical\nreceptors\tO\nwere\tO\nable\tO\nto\tO\nreverse\tO\ncatalepsy\tB-Disease\n.\tO\n\nDrugs\tO\nwith\tO\naffinity\tO\nfor\tO\nother\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\nreceptors\tO\nor\tO\nweak\tO\naffinity\tO\nwere\tO\nineffective\tO\n.\tO\n\nHowever\tO\n,\tO\ninhibition\tO\nof\tO\npostsynaptic\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\nreceptors\tO\nneither\tO\ninhibited\tO\nnor\tO\npotentiated\tO\nreversal\tO\nof\tO\ncatalepsy\tB-Disease\nand\tO\nleaves\tO\nopen\tO\nthe\tO\nquestion\tO\nas\tO\nto\tO\nthe\tO\nsite\tO\nor\tO\nmechanism\tO\nfor\tO\nthis\tO\neffect\tO\n.\tO\n\nGlycopyrronium\tB-Chemical\nrequirements\tO\nfor\tO\nantagonism\tO\nof\tO\nthe\tO\nmuscarinic\tO\nside\tO\neffects\tO\nof\tO\nedrophonium\tB-Chemical\n.\tO\n\nWe\tO\nhave\tO\ncompared\tO\n,\tO\nin\tO\n60\tO\nadult\tO\npatients\tO\n,\tO\nthe\tO\ncardiovascular\tO\neffects\tO\nof\tO\nglycopyrronium\tB-Chemical\n5\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nand\tO\n10\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\ngiven\tO\neither\tO\nsimultaneously\tO\nor\tO\n1\tO\nmin\tO\nbefore\tO\nedrophonium\tB-Chemical\n1\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\n.\tO\n\nSignificant\tO\ndifferences\tO\nbetween\tO\nthe\tO\nfour\tO\ngroups\tO\nwere\tO\ndetected\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nBoth\tO\ngroups\tO\nreceiving\tO\n10\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nshowed\tO\nincreases\tO\nin\tO\nheart\tO\nrate\tO\nof\tO\nup\tO\nto\tO\n30\tO\nbeat\tO\nmin\tO\n-\tO\n1\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\nlimits\tO\n28\tO\n-\tO\n32\tO\nbeat\tO\nmin\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nUse\tO\nof\tO\nglycopyrronium\tB-Chemical\n5\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nprovided\tO\ngreater\tO\ncardiovascular\tO\nstability\tO\nand\tO\n,\tO\ngiven\tO\n1\tO\nmin\tO\nbefore\tO\nthe\tO\nedrophonium\tB-Chemical\n,\tO\nwas\tO\nsufficient\tO\nto\tO\nminimize\tO\nearly\tO\n,\tO\nedrophonium\tB-Chemical\n-\tO\ninduced\tO\nbradycardias\tB-Disease\n.\tO\n\nThis\tO\nlow\tO\ndose\tO\nof\tO\nglycopyrronium\tB-Chemical\nprovided\tO\ngood\tO\ncontrol\tO\nof\tO\noropharyngeal\tO\nsecretions\tO\n.\tO\n\nSelective\tO\ninjection\tO\nof\tO\niopentol\tB-Chemical\n,\tO\niohexol\tB-Chemical\nand\tO\nmetrizoate\tB-Chemical\ninto\tO\nthe\tO\nleft\tO\ncoronary\tO\nartery\tO\nof\tO\nthe\tO\ndog\tO\n.\tO\n\nInduction\tO\nof\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nand\tO\ndecrease\tO\nof\tO\naortic\tO\npressure\tO\n.\tO\n\nIn\tO\ntwenty\tO\nbeagle\tO\ndogs\tO\nselective\tO\ninjections\tO\nwere\tO\nmade\tO\ninto\tO\nthe\tO\nleft\tO\ncoronary\tO\nartery\tO\nwith\tO\niopentol\tB-Chemical\n,\tO\niohexol\tB-Chemical\nand\tO\nmetrizoate\tB-Chemical\nin\tO\ndoses\tO\nof\tO\n4\tO\nml\tO\n,\tO\n8\tO\nml\tO\nand\tO\n16\tO\nml\tO\n.\tO\n\nThirty\tO\n-\tO\nsix\tO\niopentol\tB-Chemical\ninjections\tO\n,\tO\n35\tO\niohexol\tB-Chemical\ninjections\tO\nand\tO\n37\tO\nmetrizoate\tB-Chemical\ninjections\tO\nwere\tO\nmade\tO\n.\tO\n\nFrequencies\tO\nof\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nwere\tO\nsignificantly\tO\nlower\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nafter\tO\niopentol\tB-Chemical\n(\tO\n0\tO\n%\tO\n)\tO\nand\tO\niohexol\tB-Chemical\n(\tO\n3\tO\n%\tO\n)\tO\nthan\tO\nafter\tO\nmetrizoate\tB-Chemical\n(\tO\n22\tO\n%\tO\n)\tO\n.\tO\n\nIopentol\tB-Chemical\nand\tO\niohexol\tB-Chemical\nalso\tO\nproduced\tO\nsignificantly\tO\nless\tO\ndecrease\tO\nin\tO\naortic\tO\nblood\tO\npressure\tO\nthan\tO\nmetrizoate\tB-Chemical\nat\tO\nthe\tO\ndifferent\tO\ndoses\tO\n.\tO\n\nThyroid\tO\nfunction\tO\nand\tO\nurine\tO\n-\tO\nconcentrating\tO\nability\tO\nduring\tO\nlithium\tB-Chemical\ntreatment\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nsuggested\tO\nthat\tO\nadenylate\tO\ncyclase\tO\ninhibition\tO\nmay\tO\nbe\tO\nimportant\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nboth\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\nand\tO\nhypothyroidism\tB-Disease\nduring\tO\nlithium\tB-Chemical\ntreatment\tO\n.\tO\n\nWe\tO\nmeasured\tO\nserum\tO\nthyroxine\tB-Chemical\nand\tO\nurine\tO\n-\tO\nconcentrating\tO\nability\tO\n(\tO\nUmax\tO\n)\tO\nin\tO\nresponse\tO\nto\tO\ndesmopressin\tO\n(\tO\nDDAVP\tO\n)\tO\nin\tO\n85\tO\npatients\tO\nreceiving\tO\nlithium\tB-Chemical\n.\tO\n\nHypothyroidism\tB-Disease\ndeveloped\tO\nin\tO\neight\tO\npatients\tO\nwhile\tO\nthey\tO\nwere\tO\ntaking\tO\nlithium\tB-Chemical\n.\tO\n\nImpaired\tO\nUmax\tO\nwas\tO\nfound\tO\nin\tO\nboth\tO\neuthyroid\tO\nand\tO\nhypothyroid\tB-Disease\npatients\tO\nwhile\tO\nsome\tO\nhypothyroid\tB-Disease\npatients\tO\nconcentrated\tO\ntheir\tO\nurine\tO\nwell\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nthe\tO\ndominant\tO\nmechanisms\tO\nby\tO\nwhich\tO\nlithium\tB-Chemical\nexerts\tO\nthese\tO\ntwo\tO\neffects\tO\nare\tO\ndifferent\tO\n.\tO\n\nRemodelling\tO\nof\tO\nnerve\tO\nstructure\tO\nin\tO\nexperimental\tO\nisoniazid\tB-Chemical\nneuropathy\tB-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nThe\tO\nneuropathy\tB-Disease\ncaused\tO\nby\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nisoniazid\tB-Chemical\nin\tO\nrats\tO\nwas\tO\nstudied\tO\nwith\tO\na\tO\ncomputer\tO\n-\tO\nassisted\tO\nmorphometric\tO\nmethod\tO\n.\tO\n\nScatter\tO\ndiagrams\tO\nof\tO\nthe\tO\ng\tO\nratio\tO\n(\tO\nquotient\tO\nfibre\tO\ndiameter\tO\n/\tO\naxon\tO\ndiameter\tO\n)\tO\ndefine\tO\nregenerating\tO\nfibres\tO\nas\tO\na\tO\ndistinct\tO\npopulation\tO\n,\tO\ndistinguishable\tO\nfrom\tO\nthe\tO\nsurviving\tO\nfibres\tO\nby\tO\nreduced\tO\nsheath\tO\nthickness\tO\nand\tO\nreduced\tO\naxon\tO\ncalibre\tO\n.\tO\n\nThere\tO\nwas\tO\nalso\tO\nevidence\tO\nof\tO\na\tO\nsubtle\tO\ndirect\tO\ntoxic\tO\neffect\tO\non\tO\nthe\tO\nentire\tO\nfibre\tO\npopulation\tO\n,\tO\ncausing\tO\naxon\tO\nshrinkage\tO\nmasked\tO\nby\tO\nreadjustment\tO\nof\tO\nthe\tO\nmyelin\tO\nsheath\tO\n.\tO\n\nMulticenter\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nmultiple\tO\n-\tO\ndose\tO\n,\tO\nparallel\tO\n-\tO\ngroups\tO\nefficacy\tO\nand\tO\nsafety\tO\ntrial\tO\nof\tO\nazelastine\tB-Chemical\n,\tO\nchlorpheniramine\tB-Chemical\n,\tO\nand\tO\nplacebo\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nspring\tB-Disease\nallergic\tI-Disease\nrhinitis\tI-Disease\n.\tO\n\nAzelastine\tB-Chemical\n,\tO\na\tO\nnovel\tO\nantiallergic\tO\nmedication\tO\n,\tO\nwas\tO\ncompared\tO\nwith\tO\nchlorpheniramine\tB-Chemical\nmaleate\tI-Chemical\nand\tO\nplacebo\tO\nfor\tO\nefficacy\tO\nand\tO\nsafety\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nspring\tB-Disease\nallergic\tI-Disease\nrhinitis\tI-Disease\nin\tO\na\tO\nmulticenter\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nmultiple\tO\n-\tO\ndose\tO\n,\tO\nparallel\tO\n-\tO\ngroups\tO\nstudy\tO\n.\tO\n\nOne\tO\nhundred\tO\nfifty\tO\n-\tO\nfive\tO\nsubjects\tO\nparticipated\tO\n.\tO\n\nSubjects\tO\nranged\tO\nin\tO\nage\tO\nfrom\tO\n18\tO\nto\tO\n60\tO\nyears\tO\nof\tO\nage\tO\nand\tO\nhad\tO\nat\tO\nleast\tO\na\tO\n2\tO\n-\tO\nyear\tO\nhistory\tO\nof\tO\nspring\tB-Disease\nallergic\tI-Disease\nrhinitis\tI-Disease\n,\tO\nconfirmed\tO\nby\tO\npositive\tO\nskin\tO\ntest\tO\nto\tO\nspring\tO\naeroallergens\tO\n.\tO\n\nMedications\tO\nwere\tO\ngiven\tO\nfour\tO\ntimes\tO\ndaily\tO\n;\tO\nthe\tO\nazelastine\tB-Chemical\ngroups\tO\nreceived\tO\n0\tO\n.\tO\n5\tO\n,\tO\n1\tO\n.\tO\n0\tO\n,\tO\nor\tO\n2\tO\n.\tO\n0\tO\nmg\tO\nin\tO\nthe\tO\nmorning\tO\nand\tO\nevening\tO\nwith\tO\nplacebo\tO\nin\tO\nthe\tO\nearly\tO\nand\tO\nlate\tO\nafternoon\tO\n;\tO\nthe\tO\nchlorpheniramine\tB-Chemical\ngroup\tO\nreceived\tO\n4\tO\n.\tO\n0\tO\nmg\tO\nfour\tO\ntimes\tO\ndaily\tO\n.\tO\n\nDaily\tO\nsubject\tO\nsymptom\tO\ncards\tO\nwere\tO\ncompleted\tO\nduring\tO\na\tO\nscreening\tO\nperiod\tO\nto\tO\nassess\tO\npretreatment\tO\nsymptoms\tO\nand\tO\nduring\tO\na\tO\n4\tO\n-\tO\nweek\tO\ntreatment\tO\nperiod\tO\nwhile\tO\nsubjects\tO\nreceived\tO\nstudy\tO\nmedications\tO\n.\tO\n\nIndividual\tO\nsymptoms\tO\n,\tO\ntotal\tO\nsymptoms\tO\n,\tO\nand\tO\nmajor\tO\nsymptoms\tO\nwere\tO\ncompared\tO\nto\tO\ndetermine\tO\nefficacy\tO\nof\tO\nmedication\tO\n.\tO\n\nElicited\tO\n,\tO\nvolunteered\tO\n,\tO\nand\tO\nobserved\tO\nadverse\tO\nexperiences\tO\nwere\tO\nrecorded\tO\nfor\tO\neach\tO\nsubject\tO\nand\tO\ncompared\tO\namong\tO\ngroups\tO\n.\tO\n\nVital\tO\nsigns\tO\n,\tO\nbody\tO\nweights\tO\n,\tO\nserum\tO\nchemistry\tO\nvalues\tO\n,\tO\ncomplete\tO\nblood\tO\ncell\tO\ncounts\tO\n,\tO\nurine\tO\nstudies\tO\n,\tO\nand\tO\nelectrocardiograms\tO\nwere\tO\nobtained\tO\nfor\tO\neach\tO\nsubject\tO\nand\tO\ncompared\tO\namong\tO\ngroups\tO\n.\tO\n\nSymptoms\tO\nrelief\tO\nin\tO\nthe\tO\ngroup\tO\nreceiving\tO\nthe\tO\nhighest\tO\nconcentration\tO\nof\tO\nazelastine\tB-Chemical\n(\tO\n2\tO\n.\tO\n0\tO\nmg\tO\ntwice\tO\ndaily\tO\n)\tO\nwas\tO\nstatistically\tO\ngreater\tO\nthan\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\nduring\tO\nall\tO\nweeks\tO\nof\tO\nthe\tO\nstudy\tO\n.\tO\n\nLower\tO\ndoses\tO\nof\tO\nazelastine\tB-Chemical\nwere\tO\nstatistically\tO\nmore\tO\neffective\tO\nthan\tO\nplacebo\tO\nonly\tO\nduring\tO\nportions\tO\nof\tO\nthe\tO\nfirst\tO\n3\tO\nweeks\tO\nof\tO\nthe\tO\nstudy\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nalthough\tO\nthe\tO\nchlorpheniramine\tB-Chemical\ngroup\tO\ndid\tO\nhave\tO\nfewer\tO\nsymptoms\tO\nthan\tO\nthe\tO\nplacebo\tO\ngroup\tO\nduring\tO\nthe\tO\nstudy\tO\n,\tO\nthe\tO\ndifference\tO\nnever\tO\nreached\tO\nstatistical\tO\nsignificance\tO\nduring\tO\nany\tO\nweek\tO\nof\tO\nthe\tO\nstudy\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nserious\tO\nside\tO\neffects\tO\nin\tO\nany\tO\nof\tO\nthe\tO\ntreatment\tO\ngroups\tO\n.\tO\n\nDrowsiness\tB-Disease\nand\tO\naltered\tB-Disease\ntaste\tI-Disease\nperception\tI-Disease\nwere\tO\nincreased\tO\nsignificantly\tO\nover\tO\nplacebo\tO\nonly\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\nazelastine\tB-Chemical\ngroup\tO\n.\tO\n\nAzelastine\tB-Chemical\nappears\tO\nto\tO\nbe\tO\na\tO\nsafe\tO\n,\tO\nefficacious\tO\nmedication\tO\nfor\tO\nseasonal\tB-Disease\nallergic\tI-Disease\nrhinitis\tI-Disease\n.\tO\n\nToxicity\tB-Disease\ndue\tO\nto\tO\nremission\tO\ninducing\tO\ndrugs\tO\nin\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nAssociation\tO\nwith\tO\nHLA\tO\n-\tO\nB35\tO\nand\tO\nCw4\tO\nantigens\tO\n.\tO\n\nTwenty\tO\n-\tO\nfive\tO\npatients\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n(\tO\nRA\tB-Disease\n)\tO\nwho\tO\ndeveloped\tO\ntoxicity\tB-Disease\nwhile\tO\ntaking\tO\nremission\tO\ninducing\tO\ndrugs\tO\nand\tO\n30\tO\nwithout\tO\ntoxicity\tB-Disease\nwere\tO\nstudied\tO\nfor\tO\npossible\tO\nassociations\tO\nwith\tO\nclass\tO\nI\tO\nand\tO\nII\tO\nHLA\tO\nantigens\tO\n.\tO\n\nA\tO\nstrong\tO\nassociation\tO\nhas\tO\nbeen\tO\nfound\tO\nbetween\tO\nnephritis\tB-Disease\nand\tO\ndermatitis\tB-Disease\ndue\tO\nto\tO\nTiopronin\tB-Chemical\n(\tO\na\tO\nD\tB-Chemical\n-\tI-Chemical\nPenicillamine\tI-Chemical\nlike\tO\ncompound\tO\n)\tO\nand\tO\nclass\tO\nI\tO\nantigens\tO\nB35\tO\n-\tO\nCw4\tO\n,\tO\nand\tO\nbetween\tO\ndermatitis\tB-Disease\ndue\tO\nto\tO\ngold\tB-Chemical\nthiosulphate\tB-Chemical\nand\tO\nB35\tO\n.\tO\n\nCompared\tO\nto\tO\nhealthy\tO\ncontrols\tO\na\tO\nlower\tO\nDR5\tO\nfrequency\tO\nwas\tO\nobserved\tO\nin\tO\npatients\tO\nwith\tO\nRA\tB-Disease\nexcept\tO\nfor\tO\nthe\tO\nTiopronin\tB-Chemical\nrelated\tO\nnephritis\tB-Disease\ngroup\tO\n.\tO\n\nTransient\tO\ncontralateral\tB-Disease\nrotation\tI-Disease\nfollowing\tO\nunilateral\tO\nsubstantia\tB-Disease\nnigra\tI-Disease\nlesion\tI-Disease\nreflects\tO\nsusceptibility\tO\nof\tO\nthe\tO\nnigrostriatal\tO\nsystem\tO\nto\tO\nexhaustion\tO\nby\tO\namphetamine\tB-Chemical\n.\tO\n\nFollowing\tO\nunilateral\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\ninduced\tO\nSN\tB-Disease\nlesion\tI-Disease\n,\tO\na\tO\ntransient\tO\nperiod\tO\nof\tO\ncontralateral\tB-Disease\nrotation\tI-Disease\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nprecede\tO\nthe\tO\npredominant\tO\nipsilateral\tB-Disease\ncircling\tI-Disease\n.\tO\n\nIn\tO\norder\tO\nto\tO\nclarify\tO\nthe\tO\nnature\tO\nof\tO\nthis\tO\ninitial\tO\ncontralateral\tB-Disease\nrotation\tI-Disease\nwe\tO\nexamined\tO\nthe\tO\neffect\tO\nof\tO\nthe\tO\nduration\tO\nof\tO\nrecovery\tO\nperiod\tO\nafter\tO\nthe\tO\nlesion\tO\n,\tO\non\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nrotational\tB-Disease\nbehavior\tI-Disease\n.\tO\n\nThree\tO\ndays\tO\npost\tO\nlesion\tO\n,\tO\nmost\tO\nrats\tO\ncircled\tO\npredominantly\tO\ncontralaterally\tO\nto\tO\nthe\tO\nlesion\tO\n.\tO\n\nSuch\tO\ncontralateral\tB-Disease\nrotation\tI-Disease\nmay\tO\nresult\tO\nfrom\tO\neither\tO\ndegeneration\tO\n-\tO\ninduced\tO\nbreakdown\tO\nof\tO\nthe\tO\nDA\tO\npool\tO\n,\tO\nor\tO\nlesion\tO\n-\tO\ninduced\tO\nincrease\tO\nof\tO\nDA\tO\nturnover\tO\nin\tO\nthe\tO\nspared\tO\nneurons\tO\n.\tO\n\nA\tO\nsubstantial\tO\ndegree\tO\nof\tO\ncontralateral\tO\npreference\tO\nwas\tO\nstill\tO\nevident\tO\nwhen\tO\namphetamine\tB-Chemical\nwas\tO\nadministered\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\n24\tO\ndays\tO\nafter\tO\nlesioning\tO\n,\tO\nindicating\tO\ninvolvement\tO\nof\tO\nspared\tO\ncells\tO\nin\tO\nthe\tO\ncontralateral\tB-Disease\nrotation\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nregardless\tO\nof\tO\nthe\tO\nduration\tO\nof\tO\nrecovery\tO\n(\tO\nand\tO\nirrespective\tO\nof\tO\neither\tO\nlesion\tO\nvolume\tO\n,\tO\namphetamine\tB-Chemical\ndose\tO\n,\tO\nor\tO\npost\tO\n-\tO\nlesion\tO\nmotor\tO\nexercise\tO\n)\tO\n,\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nrotation\tB-Disease\ntended\tO\nto\tO\nbecome\tO\ngradually\tO\nmore\tO\nipsilateral\tO\nas\tO\nthe\tO\nobservation\tO\nsession\tO\nprogressed\tO\n,\tO\nand\tO\nall\tO\nrats\tO\ncircled\tO\nipsilaterally\tO\nto\tO\nthe\tO\nlesion\tO\nin\tO\nresponse\tO\nto\tO\nfurther\tO\namphetamine\tB-Chemical\ninjections\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\namphetamine\tB-Chemical\nhas\tO\nan\tO\nirreversible\tO\neffect\tO\non\tO\nthe\tO\npost\tO\n-\tO\nlesion\tO\nDA\tO\npool\tO\ncontributing\tO\nto\tO\ncontralateral\tB-Disease\nrotation\tI-Disease\n.\tO\n\nMitomycin\tB-Chemical\nC\tI-Chemical\nassociated\tO\nhemolytic\tB-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nMitomycin\tB-Chemical\nC\tI-Chemical\nassociated\tO\nHemolytic\tB-Disease\nUremic\tI-Disease\nSyndrome\tI-Disease\n(\tO\nHUS\tB-Disease\n)\tO\nis\tO\na\tO\npotentially\tO\nfatal\tO\nbut\tO\nuncommon\tO\ncondition\tO\nthat\tO\nis\tO\nnot\tO\nyet\tO\nwidely\tO\nrecognised\tO\n.\tO\n\nIt\tO\nconsists\tO\nof\tO\nmicroangiopathic\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n,\tO\nthrombocytopenia\tB-Disease\nand\tO\nprogressive\tO\nrenal\tB-Disease\nfailure\tI-Disease\nassociated\tO\nwith\tO\nmitomycin\tB-Chemical\nC\tI-Chemical\ntreatment\tO\nand\tO\naffects\tO\nabout\tO\n10\tO\n%\tO\nof\tO\npatients\tO\ntreated\tO\nwith\tO\nthis\tO\nagent\tO\n.\tO\n\nThe\tO\nrenal\tB-Disease\nfailure\tI-Disease\nusually\tO\ndevelops\tO\nabout\tO\n8\tO\n-\tO\n10\tO\nmth\tO\nafter\tO\nstart\tO\nof\tO\nmitomycin\tB-Chemical\nC\tI-Chemical\ntreatment\tO\nand\tO\nthe\tO\nmortality\tO\nis\tO\napproximately\tO\n60\tO\n%\tO\nfrom\tO\nrenal\tB-Disease\nfailure\tI-Disease\nor\tO\npulmonary\tB-Disease\nedema\tI-Disease\n.\tO\n\nRenal\tB-Disease\nlesions\tI-Disease\nare\tO\nsimilar\tO\nto\tO\nthose\tO\nseen\tO\nin\tO\nidiopathic\tO\nHUS\tB-Disease\nand\tO\ninclude\tO\narteriolar\tO\nfibrin\tO\nthrombi\tB-Disease\n,\tO\nexpanded\tO\nsubendothelial\tO\nzones\tO\nin\tO\nglomerular\tO\ncapillary\tO\nwalls\tO\n,\tO\nischemic\tB-Disease\nwrinkling\tO\nof\tO\nglomerular\tO\nbasement\tO\nmembranes\tO\nand\tO\nmesangiolysis\tO\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\naction\tO\nis\tO\npostulated\tO\nas\tO\nmitomycin\tB-Chemical\nC\tI-Chemical\n-\tO\ninduced\tO\nendothelial\tO\ncell\tO\ndamage\tO\n.\tO\n\nWe\tO\ndescribe\tO\nthe\tO\nclinical\tO\ncourse\tO\nand\tO\npathological\tO\nfindings\tO\nin\tO\na\tO\n65\tO\nyr\tO\n-\tO\nold\tO\nman\tO\nwith\tO\ngastric\tB-Disease\nadenocarcinoma\tI-Disease\nwho\tO\ndeveloped\tO\nrenal\tB-Disease\nfailure\tI-Disease\nand\tO\nthrombocytopenia\tB-Disease\nwhile\tO\non\tO\ntreatment\tO\nwith\tO\nmitomycin\tB-Chemical\nC\tI-Chemical\nand\tO\ndied\tO\nin\tO\npulmonary\tB-Disease\nedema\tI-Disease\n.\tO\n\nKetanserin\tB-Chemical\npretreatment\tO\nreverses\tO\nalfentanil\tB-Chemical\n-\tO\ninduced\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\n.\tO\n\nSystemic\tO\npretreatment\tO\nwith\tO\nketanserin\tB-Chemical\n,\tO\na\tO\nrelatively\tO\nspecific\tO\ntype\tO\n-\tO\n2\tO\nserotonin\tB-Chemical\nreceptor\tO\nantagonist\tO\n,\tO\nsignificantly\tO\nattenuated\tO\nthe\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\nproduced\tO\nin\tO\nrats\tO\nby\tO\nthe\tO\npotent\tO\nshort\tO\n-\tO\nacting\tO\nopiate\tO\nagonist\tO\nalfentanil\tB-Chemical\n.\tO\n\nFollowing\tO\nplacement\tO\nof\tO\nsubcutaneous\tO\nelectrodes\tO\nin\tO\neach\tO\nanimal\tO\n'\tO\ns\tO\nleft\tO\ngastrocnemius\tO\nmuscle\tO\n,\tO\nrigidity\tB-Disease\nwas\tO\nassessed\tO\nby\tO\nanalyzing\tO\nroot\tO\n-\tO\nmean\tO\n-\tO\nsquare\tO\nelectromyographic\tO\nactivity\tO\n.\tO\n\nIntraperitoneal\tO\nketanserin\tB-Chemical\nadministration\tO\nat\tO\ndoses\tO\nof\tO\n0\tO\n.\tO\n63\tO\nand\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nprevented\tO\nthe\tO\nalfentanil\tB-Chemical\n-\tO\ninduced\tO\nincrease\tO\nin\tO\nelectromyographic\tO\nactivity\tO\ncompared\tO\nwith\tO\nanimals\tO\npretreated\tO\nwith\tO\nsaline\tO\n.\tO\n\nChlordiazepoxide\tB-Chemical\nat\tO\ndoses\tO\nup\tO\nto\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nfailed\tO\nto\tO\nsignificantly\tO\ninfluence\tO\nthe\tO\nrigidity\tB-Disease\nproduced\tO\nby\tO\nalfentanil\tB-Chemical\n.\tO\n\nDespite\tO\nthe\tO\nabsence\tO\nof\tO\nrigidity\tB-Disease\n,\tO\nanimals\tO\nthat\tO\nreceived\tO\nketanserin\tB-Chemical\n(\tO\ngreater\tO\nthan\tO\n0\tO\n.\tO\n31\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nfollowed\tO\nby\tO\nalfentanil\tB-Chemical\nwere\tO\nmotionless\tO\n,\tO\nflaccid\tO\n,\tO\nand\tO\nless\tO\nresponsive\tO\nto\tO\nexternal\tO\nstimuli\tO\nthan\tO\nwere\tO\nanimals\tO\nreceiving\tO\nalfentanil\tB-Chemical\nalone\tO\n.\tO\n\nRats\tO\nthat\tO\nreceived\tO\nketanserin\tB-Chemical\nand\tO\nalfentanil\tB-Chemical\nexhibited\tO\nless\tO\nrearing\tO\nand\tO\nexploratory\tO\nbehavior\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\n60\tO\n-\tO\nmin\tO\nrecording\tO\nperiod\tO\nthan\tO\ndid\tO\nanimals\tO\nthat\tO\nreceived\tO\nketanserin\tB-Chemical\nalone\tO\n.\tO\n\nThese\tO\nresults\tO\n,\tO\nin\tO\ncombination\tO\nwith\tO\nprevious\tO\nwork\tO\n,\tO\nsuggest\tO\nthat\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\n,\tO\na\tO\nclinically\tO\nrelevant\tO\nside\tO\n-\tO\neffect\tO\nof\tO\nparenteral\tO\nnarcotic\tO\nadministration\tO\n,\tO\nmay\tO\nbe\tO\npartly\tO\nmediated\tO\nvia\tO\nserotonergic\tO\npathways\tO\n.\tO\n\nPretreatment\tO\nwith\tO\ntype\tO\n-\tO\n2\tO\nserotonin\tB-Chemical\nantagonists\tO\nmay\tO\nbe\tO\nclinically\tO\nuseful\tO\nin\tO\nattenuating\tO\nopiate\tO\n-\tO\ninduced\tO\nrigidity\tB-Disease\n,\tO\nalthough\tO\nfurther\tO\nstudies\tO\nwill\tO\nbe\tO\nnecessary\tO\nto\tO\nassess\tO\nthe\tO\ninteraction\tO\nof\tO\npossibly\tO\nenhanced\tO\nCNS\tO\n,\tO\ncardiovascular\tB-Disease\n,\tI-Disease\nand\tI-Disease\nrespiratory\tI-Disease\ndepression\tI-Disease\n.\tO\n\nAntagonism\tO\nof\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\nsedative\tO\neffects\tO\nby\tO\nRo15\tB-Chemical\n-\tI-Chemical\n1788\tI-Chemical\nin\tO\npatients\tO\nafter\tO\nsurgery\tO\nunder\tO\nlumbar\tO\nepidural\tO\nblock\tO\n.\tO\n\nA\tO\ndouble\tO\n-\tO\nblind\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ninvestigation\tO\nof\tO\nefficacy\tO\nand\tO\nsafety\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nassess\tO\nthe\tO\nefficacy\tO\nof\tO\nRo15\tB-Chemical\n-\tI-Chemical\n1788\tI-Chemical\nand\tO\na\tO\nplacebo\tO\nin\tO\nreversing\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\neffects\tO\nafter\tO\nsurgery\tO\nunder\tO\nepidural\tO\nblock\tO\n,\tO\nand\tO\nto\tO\nevaluate\tO\nthe\tO\nlocal\tO\ntolerance\tO\nand\tO\ngeneral\tO\nsafety\tO\nof\tO\nRo15\tB-Chemical\n-\tI-Chemical\n1788\tI-Chemical\n.\tO\n\nFifty\tO\n-\tO\nseven\tO\npatients\tO\nwere\tO\nsedated\tO\nwith\tO\ndiazepam\tB-Chemical\nfor\tO\nsurgery\tO\nunder\tO\nepidural\tO\nanaesthesia\tO\n.\tO\n\nAntagonism\tO\nof\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\neffects\tO\nby\tO\nRo15\tB-Chemical\n-\tI-Chemical\n1788\tI-Chemical\nwas\tO\ninvestigated\tO\npostoperatively\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrial\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nsubjective\tO\nassessment\tO\nof\tO\nmood\tO\nrating\tO\n,\tO\nan\tO\nobjective\tO\ntest\tO\nof\tO\nperformance\tO\n,\tO\na\tO\ntest\tO\nfor\tO\namnesia\tB-Disease\n,\tO\nand\tO\nvital\tO\nsigns\tO\nwere\tO\nrecorded\tO\nfor\tO\nup\tO\nto\tO\n300\tO\nmin\tO\nafter\tO\nadministration\tO\nof\tO\nthe\tO\ntrial\tO\ndrug\tO\n.\tO\n\nNo\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\nwere\tO\nobserved\tO\nfor\tO\nmood\tO\nrating\tO\n,\tO\namnesia\tB-Disease\n,\tO\nor\tO\nvital\tO\nsigns\tO\n.\tO\n\nThe\tO\nRo15\tB-Chemical\n-\tI-Chemical\n1788\tI-Chemical\ngroup\tO\nshowed\tO\na\tO\nsignificant\tO\nimprovement\tO\nin\tO\nthe\tO\nperformance\tO\ntest\tO\nup\tO\nto\tO\n120\tO\nmin\tO\nafter\tO\nadministration\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nevidence\tO\nof\tO\nreaction\tO\nat\tO\nthe\tO\ninjection\tO\nsite\tO\n.\tO\n\nChorea\tB-Disease\nassociated\tO\nwith\tO\noral\tB-Chemical\ncontraception\tI-Chemical\n.\tO\n\nThree\tO\npatients\tO\ndeveloped\tO\nchorea\tB-Disease\nwhile\tO\nreceiving\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nTwo\tO\nwere\tO\nyoung\tO\npatients\tO\nwhose\tO\nchorea\tB-Disease\ndeveloped\tO\nlong\tO\nafter\tO\ntreatment\tO\nhad\tO\nbeen\tO\nstarted\tO\nand\tO\ndisappeared\tO\nsoon\tO\nafter\tO\nit\tO\nhad\tO\nbeen\tO\ndiscontinued\tO\n.\tO\n\nThe\tO\nthird\tO\npatient\tO\nhad\tO\nacute\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nchorea\tB-Disease\nafter\tO\nprolonged\tO\noral\tB-Chemical\ncontraception\tI-Chemical\n.\tO\n\nProlonged\tO\nadministration\tO\nof\tO\nfemale\tO\nsex\tO\nhormones\tO\nis\tO\na\tO\npossible\tO\ncause\tO\nof\tO\nchorea\tB-Disease\nin\tO\nwomen\tO\nwho\tO\nhave\tO\nnot\tO\npreviously\tO\nhad\tO\nchorea\tB-Disease\nor\tO\nrheumatic\tB-Disease\nfever\tI-Disease\n.\tO\n\nCo\tO\n-\tO\ncarcinogenic\tB-Disease\neffect\tO\nof\tO\nretinyl\tB-Chemical\nacetate\tI-Chemical\non\tO\nforestomach\tB-Disease\ncarcinogenesis\tI-Disease\nof\tO\nmale\tO\nF344\tO\nrats\tO\ninduced\tO\nwith\tO\nbutylated\tB-Chemical\nhydroxyanisole\tI-Chemical\n.\tO\n\nThe\tO\npotential\tO\nmodifying\tO\neffect\tO\nof\tO\nretinyl\tB-Chemical\nacetate\tI-Chemical\n(\tO\nRA\tB-Chemical\n)\tO\non\tO\nbutylated\tB-Chemical\nhydroxyanisole\tI-Chemical\n(\tO\nBHA\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nrat\tO\nforestomach\tB-Disease\ntumorigenesis\tI-Disease\nwas\tO\nexamined\tO\n.\tO\n\nMale\tO\nF344\tO\nrats\tO\n,\tO\n5\tO\nweeks\tO\nof\tO\nage\tO\n,\tO\nwere\tO\nmaintained\tO\non\tO\ndiet\tO\ncontaining\tO\n1\tO\n%\tO\nor\tO\n2\tO\n%\tO\nBHA\tB-Chemical\nby\tO\nweight\tO\nand\tO\nsimultaneously\tO\non\tO\ndrinking\tO\nwater\tO\nsupplemented\tO\nwith\tO\nRA\tB-Chemical\nat\tO\nvarious\tO\nconcentrations\tO\n(\tO\nw\tO\n/\tO\nv\tO\n)\tO\nfor\tO\n52\tO\nweeks\tO\n.\tO\n\nIn\tO\ngroups\tO\ngiven\tO\n2\tO\n%\tO\nBHA\tB-Chemical\n,\tO\nalthough\tO\nmarked\tO\nhyperplastic\tO\nchanges\tO\nof\tO\nthe\tO\nforestomach\tO\nepithelium\tO\nwere\tO\nobserved\tO\nin\tO\nall\tO\nanimals\tO\n,\tO\nco\tO\n-\tO\nadministration\tO\nof\tO\n0\tO\n.\tO\n25\tO\n%\tO\nRA\tB-Chemical\nsignificantly\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nincreased\tO\nthe\tO\nincidence\tO\nof\tO\nforestomach\tB-Disease\ntumors\tI-Disease\n(\tO\nsquamous\tB-Disease\ncell\tI-Disease\npapilloma\tI-Disease\nand\tO\ncarcinoma\tB-Disease\n)\tO\nto\tO\n60\tO\n%\tO\n(\tO\n9\tO\n/\tO\n15\tO\n,\tO\n2\tO\nrats\tO\nwith\tO\ncarcinoma\tB-Disease\n)\tO\nfrom\tO\n15\tO\n%\tO\n(\tO\n3\tO\n/\tO\n20\tO\n,\tO\none\tO\nrat\tO\nwith\tO\ncarcinoma\tB-Disease\n)\tO\nin\tO\nthe\tO\ngroup\tO\ngiven\tO\nRA\tB-Chemical\n-\tO\nfree\tO\nwater\tO\n.\tO\n\nIn\tO\nrats\tO\ngiven\tO\n1\tO\n%\tO\nBHA\tB-Chemical\n,\tO\nRA\tB-Chemical\nco\tO\n-\tO\nadministered\tO\nat\tO\na\tO\ndose\tO\nof\tO\n0\tO\n.\tO\n05\tO\n,\tO\n0\tO\n.\tO\n1\tO\n,\tO\n0\tO\n.\tO\n2\tO\nor\tO\n0\tO\n.\tO\n25\tO\n%\tO\nshowed\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nenhancing\tO\neffect\tO\non\tO\nthe\tO\ndevelopment\tO\nof\tO\nthe\tO\nBHA\tB-Chemical\n-\tO\ninduced\tO\nepithelial\tB-Disease\nhyperplasia\tI-Disease\n.\tO\n\nTumors\tB-Disease\n,\tO\nall\tO\npapillomas\tB-Disease\n,\tO\nwere\tO\ninduced\tO\nin\tO\n3\tO\nrats\tO\n(\tO\n17\tO\n%\tO\n)\tO\nwith\tO\n0\tO\n.\tO\n25\tO\n%\tO\nRA\tB-Chemical\nand\tO\nin\tO\none\tO\nrat\tO\n(\tO\n10\tO\n%\tO\n)\tO\nwith\tO\n0\tO\n.\tO\n05\tO\n%\tO\nRA\tB-Chemical\nco\tO\n-\tO\nadministration\tO\n.\tO\n\nRA\tB-Chemical\nalone\tO\ndid\tO\nnot\tO\ninduce\tO\nhyperplastic\tO\nchanges\tO\nin\tO\nthe\tO\nforestomach\tO\n.\tO\n\nThese\tO\nfindings\tO\nindicate\tO\nthat\tO\nRA\tB-Chemical\nacted\tO\nas\tO\na\tO\nco\tO\n-\tO\ncarcinogen\tO\nin\tO\nthe\tO\nBHA\tB-Chemical\nforestomach\tB-Disease\ncarcinogenesis\tI-Disease\nof\tO\nthe\tO\nrat\tO\n.\tO\n\nA\tO\nprospective\tO\nstudy\tO\non\tO\nthe\tO\ndose\tO\ndependency\tO\nof\tO\ncardiotoxicity\tB-Disease\ninduced\tO\nby\tO\nmitomycin\tB-Chemical\nC\tI-Chemical\n.\tO\n\nSince\tO\n1975\tO\nmitomycin\tB-Chemical\nC\tI-Chemical\n(\tO\nMMC\tB-Chemical\n)\tO\nhas\tO\nbeen\tO\nsuggested\tO\nto\tO\nbe\tO\ncardiotoxic\tB-Disease\n,\tO\nespecially\tO\nwhen\tO\ncombined\tO\nwith\tO\nor\tO\ngiven\tO\nfollowing\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nData\tO\non\tO\ndose\tO\ndependency\tO\nor\tO\nincidence\tO\nconcerning\tO\nthis\tO\nside\tO\neffect\tO\nwere\tO\nnot\tO\nknown\tO\n.\tO\n\nWe\tO\nhave\tO\ninitiated\tO\na\tO\nprospective\tO\nstudy\tO\nto\tO\nobtain\tO\nsome\tO\nmore\tO\ndata\tO\non\tO\nthese\tO\nsubjects\tO\n.\tO\n\nForty\tO\n-\tO\nfour\tO\nMMC\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nwere\tO\nstudied\tO\n,\tO\n37\tO\nof\tO\nthem\tO\ncould\tO\nbe\tO\nevaluated\tO\n.\tO\n\nAll\tO\npatients\tO\nwere\tO\nstudied\tO\nby\tO\nrepeated\tO\nphysical\tO\nexaminations\tO\n,\tO\nchest\tO\nX\tO\n-\tO\nrays\tO\n,\tO\nelectro\tO\n-\tO\nand\tO\nechocardiography\tO\nand\tO\nradionuclide\tO\nleft\tO\nventricular\tO\nejection\tO\nfraction\tO\n(\tO\nEF\tO\n)\tO\ndeterminations\tO\n.\tO\n\nThe\tO\nresults\tO\nwere\tO\nevaluated\tO\nper\tO\ncumulative\tO\ndose\tO\nlevel\tO\n.\tO\n\nOne\tO\nof\tO\nthe\tO\npatients\tO\ndeveloped\tO\ncardiac\tB-Disease\nfailure\tI-Disease\nafter\tO\n30\tO\nmg\tO\nm\tO\n-\tO\n2\tO\nMMC\tB-Chemical\nand\tO\nonly\tO\n150\tO\nmg\tO\nm\tO\n-\tO\n2\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nThe\tO\ncardiac\tB-Disease\nfailure\tI-Disease\nwas\tO\npredicted\tO\nby\tO\na\tO\ndrop\tO\nin\tO\nEF\tO\ndetermined\tO\nduring\tO\na\tO\ncold\tO\npressor\tO\ntest\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\nother\tO\npatients\tO\ndeveloped\tO\nclinical\tO\ncardiotoxicity\tB-Disease\n,\tO\nnor\tO\ndid\tO\nthe\tO\nstudied\tO\nparameters\tO\nchange\tO\n.\tO\n\nThe\tO\nliterature\tO\non\tO\nthis\tO\nsubject\tO\nwas\tO\nalso\tO\nreviewed\tO\n.\tO\n\nBased\tO\non\tO\nthe\tO\ncombined\tO\ndata\tO\nfrom\tO\nthe\tO\npresent\tO\nstudy\tO\nand\tO\nthe\tO\nliterature\tO\n,\tO\nwe\tO\nsuggest\tO\nthat\tO\nMMC\tB-Chemical\n-\tO\nrelated\tO\ncardiotoxicity\tB-Disease\nis\tO\ndose\tO\ndependent\tO\n,\tO\noccurring\tO\nat\tO\ncumulative\tO\ndose\tO\nlevels\tO\nof\tO\n30\tO\nmg\tO\nm\tO\n-\tO\n2\tO\nor\tO\nmore\tO\n,\tO\nmainly\tO\nin\tO\npatients\tO\nalso\tO\n(\tO\npreviously\tO\nor\tO\nsimultaneously\tO\n)\tO\ntreated\tO\nwith\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nThe\tO\nincidence\tO\nis\tO\nlikely\tO\nto\tO\nbe\tO\nless\tO\nthan\tO\n10\tO\n%\tO\neven\tO\nfor\tO\nthis\tO\nrisk\tO\ngroup\tO\n.\tO\n\nReversible\tO\ncerebral\tB-Disease\nlesions\tI-Disease\nassociated\tO\nwith\tO\ntiazofurin\tB-Chemical\nusage\tO\n:\tO\nMR\tO\ndemonstration\tO\n.\tO\n\nTiazofurin\tB-Chemical\nis\tO\nan\tO\nexperimental\tO\nchemotherapeutic\tO\nagent\tO\ncurrently\tO\nundergoing\tO\nclinical\tO\nevaluation\tO\n.\tO\n\nWe\tO\nreport\tO\nour\tO\nresults\tO\nwith\tO\nmagnetic\tO\nresonance\tO\n(\tO\nMR\tO\n)\tO\nin\tO\ndemonstrating\tO\nreversible\tO\ncerebral\tB-Disease\nabnormalities\tI-Disease\nconcurrent\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nthis\tO\ndrug\tO\n.\tO\n\nThe\tO\nabnormalities\tO\non\tO\nMR\tO\nwere\tO\ncorrelated\tO\nwith\tO\nfindings\tO\non\tO\nCT\tO\nas\tO\nwell\tO\nas\tO\nwith\tO\ncerebral\tO\nangiography\tO\n.\tO\n\nThe\tO\nutility\tO\nof\tO\nMR\tO\nin\tO\nthe\tO\nevaluation\tO\nof\tO\npatients\tO\nreceiving\tO\nthis\tO\nnew\tO\nagent\tO\nis\tO\nillustrated\tO\n.\tO\n\nReceptor\tO\nmechanisms\tO\nof\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\nin\tO\nchronic\tO\nnicotine\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nRats\tO\nwere\tO\npretreated\tO\nwith\tO\nsaline\tO\nor\tO\nnicotine\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\n)\tO\nby\tO\nsubcutaneously\tO\nimplanting\tO\neach\tO\nanimal\tO\nwith\tO\nan\tO\nAlzet\tO\nosmotic\tO\nmini\tO\n-\tO\npump\tO\nwhich\tO\ncontinuously\tO\nreleased\tO\nsaline\tO\nor\tO\nnicotine\tB-Chemical\nfor\tO\n1\tO\n,\tO\n5\tO\nand\tO\n14\tO\ndays\tO\n.\tO\n\nAt\tO\nthe\tO\nend\tO\nof\tO\neach\tO\npretreatment\tO\nperiod\tO\n,\tO\nanimals\tO\nwere\tO\nused\tO\nfor\tO\n(\tO\ni\tO\n)\tO\ndetermining\tO\ntheir\tO\nlocomotor\tO\nresponse\tO\nto\tO\nacutely\tO\ninjected\tO\nnicotine\tB-Chemical\n(\tO\n0\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nand\tO\n(\tO\nii\tO\n)\tO\nmeasuring\tO\nthe\tO\ndensity\tO\nof\tO\nL\tO\n-\tO\n[\tO\n3H\tO\n]\tO\nnicotine\tB-Chemical\nand\tO\n[\tO\n3H\tO\n]\tO\nspiperone\tB-Chemical\nbinding\tO\nsites\tO\nin\tO\nthe\tO\nstriatum\tO\n.\tO\n\nWe\tO\nobserved\tO\nno\tO\nchanges\tO\nin\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nresponse\tO\n,\tO\nstriatal\tO\nL\tO\n-\tO\n[\tO\n3H\tO\n]\tO\nnicotine\tB-Chemical\nand\tO\n[\tO\n3H\tO\n]\tO\nspiperone\tB-Chemical\nbinding\tO\nin\tO\nthe\tO\nanimals\tO\npretreated\tO\nwith\tO\nnicotine\tB-Chemical\nfor\tO\n1\tO\nday\tO\n.\tO\n\nIn\tO\nrats\tO\nwhich\tO\nwere\tO\npretreated\tO\nwith\tO\nnicotine\tB-Chemical\nfor\tO\n5\tO\ndays\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nthe\tO\nnicotine\tB-Chemical\n-\tO\nstimulated\tO\nlocomotor\tO\nresponse\tO\nwhich\tO\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nL\tO\n-\tO\n[\tO\n3H\tO\n]\tO\nnicotine\tB-Chemical\nbinding\tO\nsites\tO\nand\tO\nalso\tO\nwith\tO\nan\tO\nelevated\tO\ndopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\nlevel\tO\nin\tO\nthe\tO\nstriatum\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\nstriatal\tO\n[\tO\n3H\tO\n]\tO\nspiperone\tB-Chemical\nbinding\tO\nsites\tO\nwas\tO\nnot\tO\naffected\tO\n.\tO\n\nIn\tO\nanimals\tO\npretreated\tO\nwith\tO\nnicotine\tB-Chemical\nfor\tO\n14\tO\ndays\tO\n,\tO\nthe\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nresponse\tO\nremained\tO\nto\tO\nbe\tO\npotentiated\tO\n.\tO\n\nHowever\tO\n,\tO\nthis\tO\nresponse\tO\nwas\tO\ncorrelated\tO\nwith\tO\nan\tO\nelevated\tO\nnumber\tO\nof\tO\nstriatal\tO\n[\tO\n3H\tO\n]\tO\nspiperone\tB-Chemical\nbinding\tO\nsites\tO\n,\tO\nwhereas\tO\nthe\tO\nnumber\tO\nof\tO\nstriatal\tO\nL\tO\n-\tO\n[\tO\n3H\tO\n]\tO\nnicotine\tB-Chemical\nbinding\tO\nsites\tO\nand\tO\nthe\tO\nstriatal\tO\nDA\tB-Chemical\nlevel\tO\nwere\tO\nnormal\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nchronic\tO\nnicotine\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\ndevelop\tO\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\nin\tO\nresponse\tO\nto\tO\nnicotine\tB-Chemical\ninitially\tO\ndue\tO\nto\tO\nincreases\tO\nof\tO\nboth\tO\nthe\tO\ndensity\tO\nof\tO\nnicotinic\tO\nreceptors\tO\nand\tO\nDA\tB-Chemical\nconcentration\tO\n,\tO\nfollowed\tO\nby\tO\ninducing\tO\nDA\tB-Chemical\nreceptor\tO\nsupersensitivity\tO\nin\tO\nthe\tO\nstriatum\tO\n.\tO\n\nAmelioration\tO\nof\tO\nbendrofluazide\tB-Chemical\n-\tO\ninduced\tO\nhypokalemia\tB-Disease\nby\tO\ntimolol\tB-Chemical\n.\tO\n\nThe\tO\nbeta\tO\nadrenergic\tO\nblocking\tO\ndrug\tO\n,\tO\ntimolol\tB-Chemical\n,\tO\ntended\tO\nto\tO\ncorrect\tO\nthe\tO\nhypokalemia\tB-Disease\nof\tO\nshort\tO\n-\tO\nterm\tO\nbendrofluazide\tB-Chemical\ntreatment\tO\nin\tO\n6\tO\nhealthy\tO\nmale\tO\nsubjects\tO\nand\tO\nalthough\tO\nthe\tO\neffect\tO\nwas\tO\nsmall\tO\nit\tO\nwas\tO\nsignificant\tO\n.\tO\n\nTimolol\tB-Chemical\nalso\tO\nreduced\tO\nthe\tO\nrise\tO\nin\tO\nplasma\tO\naldosterone\tB-Chemical\nand\tO\nurine\tO\npotassium\tB-Chemical\nexcretion\tO\nfollowing\tO\nbendrofluazide\tB-Chemical\nand\tO\nincreased\tO\nthe\tO\nurine\tO\nsodium\tB-Chemical\n/\tO\npotassium\tB-Chemical\nratio\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nevidence\tO\nof\tO\na\tO\nshift\tO\nof\tO\npotassium\tB-Chemical\nfrom\tO\nthe\tO\nintracellular\tO\nto\tO\nthe\tO\nextracellular\tO\nspace\tO\n.\tO\n\nSt\tB-Disease\n.\tI-Disease\n\nAnthony\tB-Disease\n'\tI-Disease\ns\tI-Disease\nfire\tI-Disease\n,\tO\nthen\tO\nand\tO\nnow\tO\n:\tO\na\tO\ncase\tO\nreport\tO\nand\tO\nhistorical\tO\nreview\tO\n.\tO\n\nA\tO\nrare\tO\ncase\tO\nof\tO\nmorbid\tO\nvasospasm\tB-Disease\n,\tO\ntogether\tO\nwith\tO\nstriking\tO\nangiographic\tO\nfindings\tO\n,\tO\nis\tO\ndescribed\tO\nsecondary\tO\nto\tO\nthe\tO\ningestion\tO\nof\tO\nmethysergide\tB-Chemical\nby\tO\na\tO\n48\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\n.\tO\n\nA\tO\nbrief\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\non\tO\nsimilar\tO\ncases\tO\nis\tO\npresented\tO\n.\tO\n\nA\tO\ndiscussion\tO\nof\tO\nthe\tO\nhistory\tO\nof\tO\nergot\tB-Chemical\nincludes\tO\nits\tO\noriginal\tO\ndiscovery\tO\n,\tO\nthe\tO\nepidemics\tO\nof\tO\ngangrene\tB-Disease\nthat\tO\nit\tO\nhas\tO\ncaused\tO\nthrough\tO\nthe\tO\nages\tO\nand\tO\nits\tO\npast\tO\nand\tO\npresent\tO\nrole\tO\nin\tO\nthe\tO\nmanagement\tO\nof\tO\nmigraine\tB-Disease\nheadache\tI-Disease\n.\tO\n\nDespite\tO\nthe\tO\nadvent\tO\nof\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\nand\tO\nbeta\tO\n-\tO\nadrenergic\tO\nantagonists\tO\n,\tO\nergot\tB-Chemical\npreparations\tO\ncontinue\tO\nto\tO\nplay\tO\na\tO\nmajor\tO\nrole\tO\nin\tO\nmigraine\tB-Disease\ntherapy\tO\n,\tO\nso\tO\nthat\tO\nthe\tO\ndanger\tO\nof\tO\nSt\tB-Disease\n.\tI-Disease\n\nAnthony\tB-Disease\n'\tI-Disease\ns\tI-Disease\nfire\tI-Disease\npersists\tO\n.\tO\n\nCardiac\tO\ntransplantation\tO\n:\tO\nimproved\tO\nquality\tO\nof\tO\nsurvival\tO\nwith\tO\na\tO\nmodified\tO\nimmunosuppressive\tO\nprotocol\tO\n.\tO\n\nThe\tO\neffects\tO\non\tO\nrenal\tO\nfunction\tO\non\tO\ntwo\tO\ndifferent\tO\nimmunosuppressive\tO\nprotocols\tO\nwere\tO\nevaluated\tO\nretrospectively\tO\nin\tO\ntwo\tO\nsubsequent\tO\ngroups\tO\nof\tO\nheart\tO\ntransplant\tO\nrecipients\tO\n.\tO\n\nIn\tO\ngroup\tO\nI\tO\n,\tO\ncyclosporine\tB-Chemical\nwas\tO\ngiven\tO\nbefore\tO\nthe\tO\nprocedure\tO\nat\tO\na\tO\nloading\tO\ndose\tO\nof\tO\n17\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nand\tO\nthen\tO\ncontinued\tO\nafter\tO\nthe\tO\nprocedure\tO\nto\tO\nkeep\tO\na\tO\nwhole\tO\nblood\tO\nlevel\tO\nabout\tO\n1000\tO\nng\tO\n/\tO\nml\tO\n.\tO\n\nIn\tO\ngroup\tO\nII\tO\n,\tO\ncyclosporine\tB-Chemical\nwas\tO\nstarted\tO\nonly\tO\nafter\tO\nthe\tO\nprocedure\tO\nat\tO\na\tO\nlower\tO\ndosage\tO\nand\tO\nwas\tO\ncomplemented\tO\nby\tO\nazathioprine\tB-Chemical\n,\tO\nwhich\tO\nwas\tO\nused\tO\nfor\tO\nthe\tO\nfirst\tO\npostoperative\tO\nweek\tO\n.\tO\n\nGroup\tO\nII\tO\nshowed\tO\na\tO\nbetter\tO\nperioperative\tO\nrenal\tO\nfunction\tO\nas\tO\ndetermined\tO\nby\tO\nserum\tO\nblood\tO\nurea\tB-Chemical\nnitrogen\tI-Chemical\nand\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\n.\tO\n\nGroup\tO\nII\tO\nalso\tO\nshowed\tO\na\tO\nsignificant\tO\ndecrease\tO\nof\tO\nchronic\tO\nnephrotoxicity\tB-Disease\nsecondary\tO\nto\tO\nlong\tO\n-\tO\nterm\tO\ntherapy\tO\nwith\tO\ncyclosporine\tB-Chemical\n.\tO\n\nDespite\tO\nthis\tO\nimprovement\tO\nin\tO\nlate\tO\nrenal\tO\nfunction\tO\n,\tO\ngroup\tO\nII\tO\nstill\tO\nshows\tO\na\tO\nslow\tO\nrise\tO\nin\tO\nserum\tO\ncreatinine\tB-Chemical\n.\tO\n\nWe\tO\nthink\tO\nthat\tO\neven\tO\nthese\tO\nlower\tO\ndosages\tO\nof\tO\ncyclosporine\tB-Chemical\ncan\tO\ncause\tO\nchronic\tO\nnephrotoxicity\tB-Disease\nand\tO\nthat\tO\nfurther\tO\nmodification\tO\nof\tO\nthe\tO\nimmunosuppressive\tO\nregimen\tO\nis\tO\nrequired\tO\nto\tO\ncompletely\tO\nabolish\tO\nthis\tO\ntoxic\tO\nside\tO\neffect\tO\n.\tO\n\nEthopropazine\tB-Chemical\nand\tO\nbenztropine\tB-Chemical\nin\tO\nneuroleptic\tO\n-\tO\ninduced\tO\nparkinsonism\tB-Disease\n.\tO\n\nIn\tO\na\tO\n12\tO\n-\tO\nweek\tO\ncontrolled\tO\nstudy\tO\nethopropazine\tB-Chemical\nwas\tO\ncompared\tO\nto\tO\nbenztropine\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nparkinsonism\tB-Disease\ninduced\tO\nby\tO\nfluphenazine\tB-Chemical\nenanthate\tI-Chemical\nin\tO\n60\tO\nschizophrenic\tB-Disease\noutpatients\tO\n.\tO\n\nEthopropazine\tB-Chemical\nand\tO\nbenztropine\tB-Chemical\nwere\tO\nfound\tO\nto\tO\nbe\tO\nequally\tO\neffective\tO\nin\tO\ncontrolling\tO\nparkinsonian\tB-Disease\nsymptoms\tI-Disease\nand\tO\nwere\tO\nas\tO\nefficacious\tO\nas\tO\nprocyclidine\tB-Chemical\n,\tO\ntheir\tO\nprevious\tO\nantiparkinsonian\tO\ndrug\tO\n.\tO\n\nHowever\tO\n,\tO\nbenztropine\tB-Chemical\ntreated\tO\npatients\tO\nhad\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\ntardive\tB-Disease\ndyskinesia\tI-Disease\ncompared\tO\nto\tO\ntheir\tO\ncondition\tO\nduring\tO\nprocyclindine\tB-Chemical\ntreatment\tO\n,\tO\nand\tO\nsignificantly\tO\nmore\tO\nanxiety\tB-Disease\nand\tO\ndepression\tB-Disease\nthan\tO\nethopropazine\tB-Chemical\ntreated\tO\npatients\tO\n.\tO\n\nThis\tO\nsuggests\tO\nthat\tO\nbenztropine\tB-Chemical\nis\tO\nnot\tO\nthe\tO\nanticholinergic\tO\ndrug\tO\nof\tO\nchoice\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nneuroleptic\tO\n-\tO\ninduced\tO\nparkinsonian\tB-Disease\nsymptoms\tI-Disease\n,\tO\nbecause\tO\nof\tO\nits\tO\nmore\tO\ntoxic\tO\ncentral\tO\nand\tO\nperipheral\tO\natropinic\tO\neffect\tO\n.\tO\n\nQuinidine\tB-Chemical\nphenylethylbarbiturate\tI-Chemical\n-\tO\ninduced\tO\nfulminant\tO\nhepatitis\tB-Disease\nin\tO\na\tO\npregnant\tO\nwoman\tO\n.\tO\n\nA\tO\ncase\tO\nreport\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n19\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nLaotian\tO\npatient\tO\naffected\tO\nby\tO\nfulminant\tO\nhepatitis\tB-Disease\nduring\tO\nthe\tO\nthird\tO\ntrimester\tO\nof\tO\nher\tO\npregnancy\tO\nafter\tO\na\tO\n1\tO\n-\tO\nmonth\tO\nadministration\tO\nof\tO\nquinidine\tB-Chemical\nphenylethylbarbiturate\tI-Chemical\n.\tO\n\nAfter\tO\ndelivery\tO\n,\tO\nthe\tO\npatient\tO\nunderwent\tO\northotopic\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nin\tO\ngood\tO\ncondition\tO\n16\tO\nmonths\tO\nafter\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nQuinidine\tB-Chemical\nitself\tO\nor\tO\nphenylethylbarbiturate\tB-Chemical\nmay\tO\nbe\tO\nresponsible\tO\nfor\tO\nfulminant\tO\nhepatitis\tB-Disease\nin\tO\nthis\tO\npatient\tO\n.\tO\n\nMechanisms\tO\nof\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\ninduced\tO\nby\tO\nepinephrine\tB-Chemical\n:\tO\ncomparison\tO\nwith\tO\nexercise\tO\n-\tO\ninduced\tO\nischemia\tB-Disease\n.\tO\n\nThe\tO\nrole\tO\nof\tO\nepinephrine\tB-Chemical\nin\tO\neliciting\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\nwas\tO\nexamined\tO\nin\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n.\tO\n\nObjective\tO\nsigns\tO\nof\tO\nischemia\tB-Disease\nand\tO\nfactors\tO\nincreasing\tO\nmyocardial\tO\noxygen\tB-Chemical\nconsumption\tO\nwere\tO\ncompared\tO\nduring\tO\nepinephrine\tB-Chemical\ninfusion\tO\nand\tO\nsupine\tO\nbicycle\tO\nexercise\tO\n.\tO\n\nBoth\tO\nepinephrine\tB-Chemical\nand\tO\nexercise\tO\nproduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\nas\tO\nevidenced\tO\nby\tO\nST\tO\nsegment\tO\ndepression\tB-Disease\nand\tO\nangina\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmechanisms\tO\nof\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\ninduced\tO\nby\tO\nepinephrine\tB-Chemical\nwere\tO\nsignificantly\tO\ndifferent\tO\nfrom\tO\nthose\tO\nof\tO\nexercise\tO\n.\tO\n\nExercise\tO\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\nwas\tO\nmarked\tO\npredominantly\tO\nby\tO\nincreased\tO\nheart\tO\nrate\tO\nand\tO\nrate\tO\n-\tO\npressure\tO\nproduct\tO\nwith\tO\na\tO\nminor\tO\ncontribution\tO\nof\tO\nend\tO\n-\tO\ndiastolic\tO\nvolume\tO\n,\tO\nwhile\tO\nepinephrine\tB-Chemical\n-\tO\ninduced\tO\nischemia\tB-Disease\nwas\tO\ncharacterized\tO\nby\tO\na\tO\nmarked\tO\nincrease\tO\nin\tO\ncontractility\tO\nand\tO\na\tO\nless\tO\npronounced\tO\nincrease\tO\nin\tO\nheart\tO\nrate\tO\nand\tO\nrate\tO\n-\tO\npressure\tO\nproduct\tO\n.\tO\n\nThese\tO\nfindings\tO\nindicate\tO\nthat\tO\nischemia\tB-Disease\nproduced\tO\nby\tO\nepinephrine\tB-Chemical\n,\tO\nas\tO\nmay\tO\noccur\tO\nduring\tO\nstates\tO\nof\tO\nemotional\tO\ndistress\tO\n,\tO\nhas\tO\na\tO\nmechanism\tO\ndistinct\tO\nfrom\tO\nthat\tO\ndue\tO\nto\tO\nphysical\tO\nexertion\tO\n.\tO\n\nRecent\tO\npreclinical\tO\nand\tO\nclinical\tO\nstudies\tO\nwith\tO\nthe\tO\nthymidylate\tO\nsynthase\tO\ninhibitor\tO\nN10\tB-Chemical\n-\tI-Chemical\npropargyl\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n,\tI-Chemical\n8\tI-Chemical\n-\tI-Chemical\ndideazafolic\tI-Chemical\nacid\tI-Chemical\n(\tO\nCB\tB-Chemical\n3717\tI-Chemical\n)\tO\n.\tO\n\nCB\tB-Chemical\n3717\tI-Chemical\n,\tO\nN10\tB-Chemical\n-\tI-Chemical\npropargyl\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n,\tI-Chemical\n8\tI-Chemical\n-\tI-Chemical\ndideazafolic\tI-Chemical\nacid\tI-Chemical\n,\tO\nis\tO\na\tO\ntight\tO\n-\tO\nbinding\tO\ninhibitor\tO\nof\tO\nthymidylate\tO\nsynthase\tO\n(\tO\nTS\tO\n)\tO\nwhose\tO\ncytotoxicity\tB-Disease\nis\tO\nmediated\tO\nsolely\tO\nthrough\tO\nthe\tO\ninhibition\tO\nof\tO\nthis\tO\nenzyme\tO\n.\tO\n\nRecent\tO\npreclinical\tO\nstudies\tO\nhave\tO\nfocused\tO\non\tO\nthe\tO\nintracellular\tO\nformation\tO\nof\tO\nCB\tB-Chemical\n3717\tI-Chemical\npolyglutamates\tO\n.\tO\n\nFollowing\tO\na\tO\n12\tO\n-\tO\nhour\tO\nexposure\tO\nof\tO\nL1210\tO\ncells\tO\nto\tO\n50\tO\nmicroM\tO\n[\tO\n3H\tO\n]\tO\nCB\tB-Chemical\n3717\tI-Chemical\n,\tO\n30\tO\n%\tO\nof\tO\nthe\tO\nextractable\tO\nradioactivity\tO\ncould\tO\nbe\tO\naccounted\tO\nfor\tO\nas\tO\nCB\tB-Chemical\n3717\tI-Chemical\ntetra\tO\n-\tO\nand\tO\npentaglutamate\tO\n,\tO\nas\tO\ndetermined\tO\nby\tO\nhigh\tO\n-\tO\npressure\tO\nliquid\tO\nchromatography\tO\n(\tO\nHPLC\tO\n)\tO\nanalyses\tO\n.\tO\n\nAs\tO\ninhibitors\tO\nof\tO\nisolated\tO\nL1210\tO\nTS\tO\n,\tO\nCB\tO\n3717\tO\ndi\tO\n-\tO\n,\tO\ntri\tO\n-\tO\n,\tO\ntetra\tO\n-\tO\nand\tO\npentaglutamate\tO\nare\tO\n26\tO\n-\tO\n,\tO\n87\tO\n-\tO\n,\tO\n119\tO\n-\tO\nand\tO\n114\tO\n-\tO\nfold\tO\nmore\tO\npotent\tO\nthan\tO\nCB\tB-Chemical\n3717\tI-Chemical\n,\tO\nrespectively\tO\n,\tO\nand\tO\ntheir\tO\nformation\tO\nmay\tO\n,\tO\ntherefore\tO\n,\tO\nbe\tO\nan\tO\nimportant\tO\ndeterminant\tO\nof\tO\nCB\tB-Chemical\n3717\tI-Chemical\ncytotoxicity\tB-Disease\n.\tO\n\nIn\tO\nearly\tO\nclinical\tO\nstudies\tO\nwith\tO\nCB\tB-Chemical\n3717\tI-Chemical\n,\tO\nactivity\tO\nhas\tO\nbeen\tO\nseen\tO\nin\tO\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\novarian\tB-Disease\ncancer\tI-Disease\n,\tO\nhepatoma\tB-Disease\n,\tO\nand\tO\nmesothelioma\tB-Disease\n.\tO\n\nToxicities\tB-Disease\nincluded\tO\nhepatotoxicity\tB-Disease\n,\tO\nmalaise\tB-Disease\n,\tO\nand\tO\ndose\tO\n-\tO\nlimiting\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nThis\tO\nlatter\tO\neffect\tO\nis\tO\nthought\tO\nto\tO\nbe\tO\ndue\tO\nto\tO\ndrug\tO\nprecipitation\tO\nwithin\tO\nthe\tO\nrenal\tO\ntubule\tO\nas\tO\na\tO\nresult\tO\nof\tO\nthe\tO\npoor\tO\nsolubility\tO\nof\tO\nCB\tB-Chemical\n3717\tI-Chemical\nunder\tO\nacidic\tO\nconditions\tO\n.\tO\n\nIn\tO\nan\tO\nattempt\tO\nto\tO\novercome\tO\nthis\tO\nproblem\tO\n,\tO\na\tO\nclinical\tO\ntrial\tO\nof\tO\nCB\tB-Chemical\n3717\tI-Chemical\nadministered\tO\nwith\tO\nalkaline\tO\ndiuresis\tO\nis\tO\nunder\tO\nway\tO\n.\tO\n\nPreliminary\tO\nresults\tO\nat\tO\n400\tO\nand\tO\n500\tO\nmg\tO\n/\tO\nm2\tO\nsuggest\tO\nthat\tO\na\tO\nreduction\tO\nin\tO\nnephrotoxicity\tB-Disease\nmay\tO\nhave\tO\nbeen\tO\nachieved\tO\nwith\tO\nonly\tO\n1\tO\ninstance\tO\nof\tO\nrenal\tB-Disease\ntoxicity\tI-Disease\nin\tO\n10\tO\npatients\tO\n.\tO\n\nHepatotoxicity\tB-Disease\nand\tO\nmalaise\tB-Disease\nare\tO\nagain\tO\nthe\tO\nmost\tO\nfrequent\tO\nside\tO\neffects\tO\n.\tO\n\nEvidence\tO\nof\tO\nantitumor\tO\nactivity\tO\nhas\tO\nbeen\tO\nseen\tO\nin\tO\n3\tO\npatients\tO\n.\tO\n\nPharmacokinetic\tO\ninvestigations\tO\nhave\tO\nshown\tO\nthat\tO\nalkaline\tO\ndiuresis\tO\ndoes\tO\nnot\tO\nalter\tO\nCB\tB-Chemical\n3717\tI-Chemical\nplasma\tO\nlevels\tO\nor\tO\nurinary\tO\nexcretion\tO\nand\tO\nthat\tO\nsatisfactory\tO\nurinary\tO\nalkalinization\tO\ncan\tO\nbe\tO\nreadily\tO\nachieved\tO\n.\tO\n\nType\tB-Disease\nB\tI-Disease\nhepatitis\tI-Disease\nafter\tO\nneedle\tO\n-\tO\nstick\tO\nexposure\tO\n:\tO\nprevention\tO\nwith\tO\nhepatitis\tB-Disease\nB\tI-Disease\nimmune\tO\nglobulin\tO\n.\tO\n\nFinal\tO\nreport\tO\nof\tO\nthe\tO\nVeterans\tO\nAdministration\tO\nCooperative\tO\nStudy\tO\n.\tO\n\nHepatitis\tB-Disease\nB\tI-Disease\nimmune\tO\nglobulin\tO\n(\tO\nHBIG\tO\n)\tO\nand\tO\nimmune\tO\nserum\tO\nglobulin\tO\n(\tO\nISG\tO\n)\tO\nwere\tO\nexamined\tO\nin\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\ntrial\tO\nto\tO\nassess\tO\ntheir\tO\nrelative\tO\nefficacies\tO\nin\tO\npreventing\tO\ntype\tB-Disease\nB\tI-Disease\nhepatitis\tI-Disease\nafter\tO\nneedle\tO\n-\tO\nstick\tO\nexposure\tO\nto\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nsurface\tI-Chemical\nantigen\tI-Chemical\n(\tO\nHBsAG\tB-Chemical\n)\tO\n-\tO\npositive\tO\ndonors\tO\n.\tO\n\nClinical\tO\nhepatitis\tB-Disease\ndeveloped\tO\nin\tO\n1\tO\n.\tO\n4\tO\n%\tO\nof\tO\nHBIG\tO\nand\tO\nin\tO\n5\tO\n.\tO\n9\tO\n%\tO\nof\tO\nISG\tO\nrecipients\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n016\tO\n)\tO\n,\tO\nand\tO\nseroconversion\tO\n(\tO\nanti\tO\n-\tO\nHBs\tO\n)\tO\noccurred\tO\nin\tO\n5\tO\n.\tO\n6\tO\n%\tO\nand\tO\n20\tO\n.\tO\n7\tO\n%\tO\nof\tO\nthem\tO\nrespectively\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nMild\tO\nand\tO\ntransient\tO\nside\tO\n-\tO\neffects\tO\nwere\tO\nnoted\tO\nin\tO\n3\tO\n.\tO\n0\tO\n%\tO\nof\tO\nISG\tO\nand\tO\nin\tO\n3\tO\n.\tO\n2\tO\n%\tO\nof\tO\nHBIG\tO\nrecipients\tO\n.\tO\n\nAvailable\tO\ndonor\tO\nsera\tO\nwere\tO\nexamined\tO\nfor\tO\nDNA\tO\npolymerase\tO\n(\tO\nDNAP\tO\n)\tO\nand\tO\ne\tO\nantigen\tO\nand\tO\nantibody\tO\n(\tO\nHBeAg\tB-Chemical\n;\tO\nanti\tO\n-\tO\nHBE\tO\n)\tO\n.\tO\n\nBoth\tO\nDNAP\tO\nand\tO\nHBeAg\tB-Chemical\nshowed\tO\na\tO\nhighly\tO\nstatistically\tO\nsignificant\tO\ncorrelation\tO\nwith\tO\nthe\tO\ninfectivity\tO\nof\tO\nHBsAg\tB-Chemical\n-\tO\npositive\tO\ndonors\tO\n.\tO\n\nHepatitis\tB-Disease\nB\tI-Disease\nimmune\tO\nglobulin\tO\nremained\tO\nsignificantly\tO\nsuperior\tO\nto\tO\nISG\tO\nin\tO\npreventing\tO\ntype\tB-Disease\nB\tI-Disease\nhepatitis\tI-Disease\neven\tO\nwhen\tO\nthe\tO\nanalysis\tO\nwas\tO\nconfined\tO\nto\tO\nthese\tO\ntwo\tO\nhigh\tO\n-\tO\nrisk\tO\nsubgroups\tO\n.\tO\n\nThe\tO\nefficacy\tO\nof\tO\nISG\tO\nin\tO\npreventing\tO\ntype\tB-Disease\nB\tI-Disease\nhepatitis\tI-Disease\ncannot\tO\nbe\tO\nascertained\tO\nbecause\tO\na\tO\ntrue\tO\nplacebo\tO\ngroup\tO\nwas\tO\nnot\tO\nincluded\tO\n.\tO\n\nProduction\tO\nof\tO\nautochthonous\tO\nprostate\tB-Disease\ncancer\tI-Disease\nin\tO\nLobund\tO\n-\tO\nWistar\tO\nrats\tO\nby\tO\ntreatments\tO\nwith\tO\nN\tB-Chemical\n-\tI-Chemical\nnitroso\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\nmethylurea\tI-Chemical\nand\tO\ntestosterone\tB-Chemical\n.\tO\n\nMore\tO\nthan\tO\n50\tO\n%\tO\nof\tO\nLobund\tO\n-\tO\nWistar\tO\n(\tO\nL\tO\n-\tO\nW\tO\n)\tO\nstrain\tO\nrats\tO\ndeveloped\tO\nlarge\tO\n,\tO\npalpable\tO\nprostate\tB-Disease\nadenocarcinomas\tI-Disease\n(\tO\nPAs\tB-Disease\n)\tO\nfollowing\tO\ntreatments\tO\nwith\tO\nN\tB-Chemical\n-\tI-Chemical\nnitroso\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\nmethylurea\tI-Chemical\n(\tO\nCAS\tO\n:\tO\n684\tO\n-\tO\n93\tO\n-\tO\n5\tO\n)\tO\nand\tO\ntestosterone\tB-Chemical\npropionate\tI-Chemical\n[\tO\n(\tO\nTP\tB-Chemical\n)\tO\nCAS\tO\n:\tO\n57\tO\n-\tO\n85\tO\n-\tO\n2\tO\n]\tO\n,\tO\nand\tO\nmost\tO\nof\tO\nthe\tO\ntumor\tB-Disease\n-\tO\nbearing\tO\nrats\tO\nmanifested\tO\nmetastatic\tO\nlesions\tO\n.\tO\n\nThe\tO\nincubation\tO\nperiods\tO\naveraged\tO\n10\tO\n.\tO\n6\tO\nmonths\tO\n.\tO\n\nWithin\tO\nthe\tO\nsame\tO\ntimeframe\tO\n,\tO\nno\tO\nL\tO\n-\tO\nW\tO\nrat\tO\ndeveloped\tO\na\tO\nsimilar\tO\npalpable\tO\nPA\tB-Disease\nwhen\tO\ntreated\tO\nonly\tO\nwith\tO\nTP\tB-Chemical\n.\tO\n\nIn\tO\nL\tO\n-\tO\nW\tO\nrats\tO\n,\tO\nTP\tB-Chemical\nacted\tO\nas\tO\na\tO\ntumor\tB-Disease\nenhancement\tO\nagent\tO\n,\tO\nwith\tO\nprimary\tO\nemphasis\tO\non\tO\nthe\tO\ndevelopment\tO\nof\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nRelative\tO\nefficacy\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\nnetilmicin\tB-Chemical\nand\tO\ntobramycin\tB-Chemical\nin\tO\noncology\tO\npatients\tO\n.\tO\n\nWe\tO\nprospectively\tO\ncompared\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\nnetilmicin\tB-Chemical\nsulfate\tI-Chemical\nor\tO\ntobramycin\tB-Chemical\nsulfate\tI-Chemical\nin\tO\nconjunction\tO\nwith\tO\npiperacillin\tB-Chemical\nsodium\tI-Chemical\nin\tO\n118\tO\nimmunocompromised\tO\npatients\tO\nwith\tO\npresumed\tO\nsevere\tO\ninfections\tB-Disease\n.\tO\n\nThe\tO\ntwo\tO\ntreatment\tO\nregimens\tO\nwere\tO\nequally\tO\nefficacious\tO\n.\tO\n\nNephrotoxicity\tB-Disease\noccurred\tO\nin\tO\na\tO\nsimilar\tO\nproportion\tO\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nnetilmicin\tB-Chemical\nand\tO\ntobramycin\tB-Chemical\n(\tO\n17\tO\n%\tO\nvs\tO\n11\tO\n%\tO\n)\tO\n.\tO\n\nOtotoxicity\tB-Disease\noccurred\tO\nin\tO\nfour\tO\n(\tO\n9\tO\n.\tO\n5\tO\n%\tO\n)\tO\nof\tO\n42\tO\nnetilmicin\tB-Chemical\nand\tO\npiperacillin\tB-Chemical\nand\tO\nin\tO\n12\tO\n(\tO\n22\tO\n%\tO\n)\tO\nof\tO\n54\tO\ntobramycin\tB-Chemical\nand\tO\npiperacillin\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\n.\tO\n\nOf\tO\nthose\tO\nevaluated\tO\nwith\tO\nposttherapy\tO\naudiograms\tO\n,\tO\nthree\tO\nof\tO\nfour\tO\nnetilmicin\tB-Chemical\nand\tO\npiperacillin\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nhad\tO\nauditory\tO\nthresholds\tO\nreturn\tO\nto\tO\nbaseline\tO\ncompared\tO\nwith\tO\none\tO\nof\tO\nnine\tO\ntobramycin\tB-Chemical\nand\tO\npiperacillin\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n15\tO\n-\tO\ndB\tO\nincreases\tO\nin\tO\nauditory\tO\nthreshold\tO\nas\tO\na\tO\nproportion\tO\nof\tO\ntotal\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n15\tO\n-\tO\ndB\tO\nchanges\tO\n(\tO\nincreases\tO\nand\tO\ndecreases\tO\n)\tO\nwas\tO\nsignificantly\tO\nlower\tO\nin\tO\nnetilmicin\tB-Chemical\nand\tO\npiperacillin\tB-Chemical\n-\tO\nvs\tO\ntobramycin\tB-Chemical\nand\tO\npiperacillin\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\n(\tO\n18\tO\nof\tO\n78\tO\nvs\tO\n67\tO\nof\tO\n115\tO\n)\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\naminoglycoside\tB-Chemical\n-\tO\nassociated\tO\nototoxicity\tB-Disease\nwas\tO\nless\tO\nsevere\tO\nand\tO\nmore\tO\noften\tO\nreversible\tO\nwith\tO\nnetilmicin\tB-Chemical\nthan\tO\nwith\tO\ntobramycin\tB-Chemical\n.\tO\n\nUrinary\tO\nenzymes\tO\nand\tO\nprotein\tO\npatterns\tO\nas\tO\nindicators\tO\nof\tO\ninjury\tB-Disease\nto\tI-Disease\ndifferent\tI-Disease\nregions\tI-Disease\nof\tI-Disease\nthe\tI-Disease\nkidney\tI-Disease\n.\tO\n\nAcute\tB-Disease\nexperimental\tI-Disease\nmodels\tI-Disease\nof\tI-Disease\nrenal\tI-Disease\ndamage\tI-Disease\nto\tO\nthe\tO\nproximal\tO\ntubular\tO\n,\tO\nglomerular\tO\n,\tO\nand\tO\npapillary\tO\nregions\tO\nof\tO\nthe\tO\nrat\tO\nwere\tO\nproduced\tO\nby\tO\nadministration\tO\nof\tO\nhexachloro\tB-Chemical\n-\tI-Chemical\n1\tI-Chemical\n:\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nbutadiene\tI-Chemical\n(\tO\nHCBD\tB-Chemical\n)\tO\n,\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n)\tO\n,\tO\nand\tO\n2\tB-Chemical\n-\tI-Chemical\nbromoethylamine\tI-Chemical\n(\tO\nBEA\tB-Chemical\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nSeveral\tO\nroutine\tO\nindicators\tO\nof\tO\nnephrotoxicity\tB-Disease\n,\tO\nthe\tO\nenzymes\tO\nalkaline\tO\nphosphatase\tO\nand\tO\nN\tO\n-\tO\nacetyl\tO\n-\tO\nbeta\tO\n-\tO\nglucosaminidase\tO\n,\tO\nand\tO\nthe\tO\nmolecular\tO\nweight\tO\nof\tO\nprotein\tB-Disease\nexcretion\tI-Disease\nwere\tO\ndetermined\tO\non\tO\nurine\tO\nsamples\tO\n.\tO\n\nTubular\tO\ndamage\tO\nproduced\tO\nby\tO\nHCBD\tB-Chemical\nor\tO\nBEA\tB-Chemical\nwas\tO\ndiscriminated\tO\nboth\tO\nquantitatively\tO\nand\tO\nqualitatively\tO\nfrom\tO\nglomerular\tB-Disease\ndamage\tI-Disease\nproduced\tO\nby\tO\nPAN\tB-Chemical\n.\tO\n\nThe\tO\nlatter\tO\nwas\tO\ncharacterized\tO\nby\tO\na\tO\npronounced\tO\nincrease\tO\nin\tO\nprotein\tB-Disease\nexcretion\tI-Disease\n,\tO\nespecially\tO\nproteins\tO\nwith\tO\nmolecular\tO\nweight\tO\ngreater\tO\nthan\tO\n40\tO\n,\tO\n000\tO\nDa\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nprotein\tB-Disease\nexcretion\tI-Disease\nin\tO\ntubular\tO\ndamage\tO\nwas\tO\nraised\tO\nonly\tO\nslightly\tO\nand\tO\ncharacterized\tO\nby\tO\nexcretion\tB-Disease\nof\tI-Disease\nproteins\tI-Disease\nof\tO\na\tO\nwide\tO\nrange\tO\nof\tO\nmolecular\tO\nweights\tO\n.\tO\n\nProximal\tO\ntubular\tO\ndamage\tO\ncaused\tO\nby\tO\nHCBD\tB-Chemical\nand\tO\npapillary\tO\ndamage\tO\ncaused\tO\nby\tO\nBEA\tB-Chemical\nwere\tO\ndistinguished\tO\nboth\tO\nby\tO\nconventional\tO\nurinalysis\tO\n(\tO\nvolume\tO\nand\tO\nspecific\tO\ngravity\tO\n)\tO\nand\tO\nby\tO\nmeasurement\tO\nof\tO\nthe\tO\ntwo\tO\nurinary\tO\nenzymes\tO\n.\tO\n\nAlkaline\tO\nphosphatase\tO\nand\tO\nglucose\tB-Chemical\nwere\tO\nmarkedly\tO\nand\tO\ntransiently\tO\nelevated\tO\nin\tO\nproximal\tO\ntubular\tO\ndamage\tO\nand\tO\nN\tO\n-\tO\nacetyl\tO\n-\tO\nbeta\tO\n-\tO\nglucosaminidase\tO\nshowed\tO\na\tO\nsustained\tO\nelevation\tO\nin\tO\npapillary\tO\ndamage\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nboth\tO\nselective\tO\nurinary\tO\nenzymes\tO\nand\tO\nthe\tO\nmolecular\tO\nweight\tO\npattern\tO\nof\tO\nurinary\tO\nproteins\tO\ncan\tO\nbe\tO\nused\tO\nto\tO\nprovide\tO\ndiagnostic\tO\ninformation\tO\nabout\tO\nthe\tO\npossible\tO\nsite\tO\nof\tO\nrenal\tB-Disease\ndamage\tI-Disease\n.\tO\n\nA\tO\ncatch\tO\nin\tO\nthe\tO\nReye\tB-Disease\n.\tO\n\nTwenty\tO\n-\tO\nsix\tO\ncases\tO\nof\tO\nReye\tB-Disease\nsyndrome\tI-Disease\nfrom\tO\nThe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\n,\tO\nCamperdown\tO\n,\tO\nAustralia\tO\n,\tO\noccurring\tO\nbetween\tO\n1973\tO\nand\tO\n1982\tO\nwere\tO\nreviewed\tO\n.\tO\n\nOf\tO\nthese\tO\n,\tO\n20\tO\ncases\tO\nmet\tO\nthe\tO\nUS\tO\nPublic\tO\nHealth\tO\nService\tO\nCenters\tO\nfor\tO\nDisease\tO\nControl\tO\ncriteria\tO\nfor\tO\nthe\tO\ndiagnosis\tO\nof\tO\nReye\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nAspirin\tB-Chemical\nor\tO\nsalicylate\tB-Chemical\ningestion\tO\nhad\tO\noccurred\tO\nin\tO\nonly\tO\none\tO\nof\tO\nthe\tO\n20\tO\ncases\tO\n(\tO\n5\tO\n%\tO\n)\tO\n,\tO\nand\tO\nparacetamol\tB-Chemical\n(\tO\nacetaminophen\tB-Chemical\n)\tO\nhad\tO\nbeen\tO\nadministered\tO\nin\tO\nonly\tO\nsix\tO\nof\tO\nthe\tO\ncases\tO\n(\tO\n30\tO\n%\tO\n)\tO\n.\tO\n\nPathologic\tO\nconfirmation\tO\nof\tO\nthe\tO\ndiagnosis\tO\nof\tO\nReye\tB-Disease\nsyndrome\tI-Disease\nwas\tO\naccomplished\tO\nin\tO\n90\tO\n%\tO\nof\tO\nthe\tO\ncases\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nReye\tB-Disease\nsyndrome\tI-Disease\nin\tO\nNew\tO\nSouth\tO\nWales\tO\n,\tO\nAustralia\tO\n,\tO\nis\tO\nestimated\tO\nfrom\tO\nthis\tO\nstudy\tO\nto\tO\nbe\tO\napproximately\tO\nnine\tO\ncases\tO\nper\tO\n1\tO\nmillion\tO\nchildren\tO\ncompared\tO\nwith\tO\nrecent\tO\nUS\tO\ndata\tO\nof\tO\nten\tO\nto\tO\n20\tO\ncases\tO\nper\tO\n1\tO\nmillion\tO\nchildren\tO\nand\tO\nthree\tO\nto\tO\nseven\tO\ncases\tO\nper\tO\n1\tO\nmillion\tO\nchildren\tO\nin\tO\nGreat\tO\nBritain\tO\n.\tO\n\nThe\tO\nmortality\tO\nfor\tO\nthese\tO\nReye\tB-Disease\nsyndrome\tI-Disease\ncases\tO\nin\tO\nAustralia\tO\nwas\tO\n45\tO\n%\tO\nas\tO\ncompared\tO\nwith\tO\na\tO\n32\tO\n%\tO\ncase\tO\n-\tO\nfatality\tO\nrate\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tO\n\nIn\tO\nAustralia\tO\n,\tO\nthe\tO\npediatric\tO\nusage\tO\nof\tO\naspirin\tB-Chemical\nhas\tO\nbeen\tO\nextremely\tO\nlow\tO\nfor\tO\nthe\tO\npast\tO\n25\tO\nyears\tO\n(\tO\nless\tO\nthan\tO\n1\tO\n%\tO\nof\tO\ntotal\tO\ndosage\tO\nunits\tO\nsold\tO\n)\tO\n,\tO\nwith\tO\nparacetamol\tB-Chemical\n(\tO\nacetaminophen\tB-Chemical\n)\tO\ndominating\tO\nthe\tO\npediatric\tO\nanalgesic\tO\nand\tO\nantipyretic\tO\nmarket\tO\n.\tO\n\nReye\tB-Disease\nsyndrome\tI-Disease\nmay\tO\nbe\tO\ndisappearing\tO\nfrom\tO\nAustralia\tO\ndespite\tO\na\tO\ntotal\tO\nlack\tO\nof\tO\nassociation\tO\nwith\tO\nsalicylates\tB-Chemical\nor\tO\naspirin\tB-Chemical\ningestion\tO\n,\tO\nsince\tO\nthere\tO\nwere\tO\nno\tO\ncases\tO\nfound\tO\nat\tO\nThe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nin\tO\n1983\tO\n,\tO\n1984\tO\n,\tO\nor\tO\n1985\tO\n.\tO\n\nPostpartum\tO\npsychosis\tB-Disease\ninduced\tO\nby\tO\nbromocriptine\tB-Chemical\n.\tO\n\nTwo\tO\nmultigravida\tO\npatients\tO\nwith\tO\nno\tO\nprior\tO\npsychiatric\tB-Disease\nhistory\tO\nwere\tO\nseen\tO\nwith\tO\npostpartum\tO\npsychosis\tB-Disease\n,\tO\nhaving\tO\nreceived\tO\nbromocriptine\tB-Chemical\nfor\tO\ninhibition\tB-Disease\nof\tI-Disease\nlactation\tI-Disease\n.\tO\n\nBromocriptine\tB-Chemical\ngiven\tO\nin\tO\nhigh\tO\ndoses\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\npsychosis\tB-Disease\nin\tO\npatients\tO\nreceiving\tO\nthe\tO\ndrug\tO\nfor\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nThese\tO\ncases\tO\ndemonstrate\tO\nthat\tO\nbromocriptine\tB-Chemical\nmay\tO\ncause\tO\npsychosis\tB-Disease\neven\tO\nwhen\tO\ngiven\tO\nin\tO\nlow\tO\ndoses\tO\n.\tO\n\nHyperglycemic\tB-Disease\nacidotic\tI-Disease\ncoma\tI-Disease\nand\tO\ndeath\tO\nin\tO\nKearns\tB-Disease\n-\tI-Disease\nSayre\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nThis\tO\npaper\tO\npresents\tO\nthe\tO\nclinical\tO\nand\tO\nmetabolic\tO\nfindings\tO\nin\tO\ntwo\tO\nyoung\tO\nboys\tO\nwith\tO\nlong\tO\n-\tO\nstanding\tO\nKearns\tB-Disease\n-\tI-Disease\nSayre\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nFollowing\tO\nshort\tO\nexposure\tO\nto\tO\noral\tO\nprednisone\tB-Chemical\n,\tO\nboth\tO\nboys\tO\ndeveloped\tO\nlethargy\tB-Disease\n,\tO\nincreasing\tO\nsomnolence\tB-Disease\n,\tO\npolydipsia\tB-Disease\n,\tO\npolyphagia\tB-Disease\n,\tO\nand\tO\npolyuria\tB-Disease\n.\tO\n\nBoth\tO\npresented\tO\nin\tO\nthe\tO\nemergency\tO\nroom\tO\nwith\tO\nprofound\tO\ncoma\tB-Disease\n,\tO\nhypotension\tB-Disease\n,\tO\nsevere\tO\nhyperglycemia\tB-Disease\n,\tO\nand\tO\nacidosis\tB-Disease\n.\tO\n\nNonketotic\tO\nlactic\tB-Disease\nacidosis\tI-Disease\nwas\tO\npresent\tO\nin\tO\none\tO\nand\tO\nketosis\tB-Disease\nwithout\tO\na\tO\nknown\tO\nserum\tO\nlactate\tB-Chemical\nlevel\tO\nwas\tO\npresent\tO\nin\tO\nthe\tO\nother\tO\n.\tO\n\nRespiratory\tB-Disease\nfailure\tI-Disease\nrapidly\tO\nensued\tO\nand\tO\nboth\tO\npatients\tO\nexpired\tO\nin\tO\nspite\tO\nof\tO\nefforts\tO\nat\tO\nresuscitation\tO\n.\tO\n\nWe\tO\nbelieve\tO\nthese\tO\ntwo\tO\ncases\tO\nrepresent\tO\na\tO\nnewly\tO\ndescribed\tO\nand\tO\ncatastrophic\tO\nmetabolic\tB-Disease\n-\tI-Disease\nendocrine\tI-Disease\nfailure\tI-Disease\nin\tO\nthe\tO\nKearns\tB-Disease\n-\tI-Disease\nSayre\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nExperimental\tO\ncyclosporine\tB-Chemical\nnephrotoxicity\tB-Disease\n:\tO\nrisk\tO\nof\tO\nconcomitant\tO\nchemotherapy\tO\n.\tO\n\nThe\tO\nrole\tO\nof\tO\ncyclosporine\tB-Chemical\n(\tO\nCSA\tB-Chemical\n)\tO\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nvarious\tO\nchemotherapeutics\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nrenal\tB-Disease\ntoxicity\tI-Disease\nwas\tO\nevaluated\tO\nin\tO\nrats\tO\n.\tO\n\nAdministration\tO\nof\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nCSA\tB-Chemical\nfor\tO\n4\tO\nweeks\tO\ncaused\tO\nrenal\tO\nfunctional\tO\nand\tO\nstructural\tO\nchanges\tO\nsimilar\tO\nto\tO\nthose\tO\nreported\tO\nin\tO\nman\tO\n.\tO\n\nThe\tO\ncombined\tO\nadministration\tO\nof\tO\nCSA\tB-Chemical\nand\tO\nvarious\tO\nchemotherapeutic\tO\ndrugs\tO\nwith\tO\na\tO\nnephrotoxic\tB-Disease\npotential\tO\n,\tO\nsuch\tO\nas\tO\ngentamicin\tB-Chemical\n(\tO\nat\tO\ntherapeutic\tO\ndoses\tO\n)\tO\n,\tO\namphothericin\tB-Chemical\nB\tI-Chemical\nand\tO\nketoconazole\tB-Chemical\n,\tO\nwhich\tO\nare\tO\nfrequently\tO\nused\tO\nin\tO\nimmunosuppressed\tO\npatients\tO\n,\tO\ndid\tO\nnot\tO\naggravate\tO\nthe\tO\nCSA\tB-Chemical\ninduced\tO\ntoxicity\tB-Disease\nin\tO\nthe\tO\nrat\tO\nmodel\tO\n.\tO\n\nGentamicin\tB-Chemical\nat\tO\ntoxic\tO\ndoses\tO\n,\tO\nhowever\tO\n,\tO\nincreased\tO\nCSA\tB-Chemical\nnephrotoxicity\tB-Disease\n.\tO\n\nThus\tO\n,\tO\nthe\tO\nnephrotoxicity\tB-Disease\ninduced\tO\nby\tO\nCSA\tB-Chemical\nhas\tO\na\tO\ndifferent\tO\npathogenetic\tO\nmechanism\tO\n.\tO\n\nDiuretics\tO\n,\tO\npotassium\tB-Chemical\nand\tO\narrhythmias\tB-Disease\nin\tO\nhypertensive\tB-Disease\ncoronary\tB-Disease\ndisease\tI-Disease\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nproposed\tO\nthat\tO\nmodest\tO\nchanges\tO\nin\tO\nplasma\tO\npotassium\tB-Chemical\ncan\tO\nalter\tO\nthe\tO\ntendency\tO\ntowards\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\n.\tO\n\nIf\tO\nthis\tO\nwere\tO\nso\tO\n,\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nmight\tO\nbe\tO\nespecially\tO\nsusceptible\tO\n.\tO\n\nThus\tO\n,\tO\nmyocardial\tO\nelectrical\tO\nexcitability\tO\nwas\tO\nmeasured\tO\nin\tO\npatients\tO\nwith\tO\nmild\tO\nessential\tO\nhypertension\tB-Disease\nand\tO\nknown\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nafter\tO\n8\tO\nweeks\tO\nof\tO\ntreatment\tO\nwith\tO\na\tO\npotassium\tB-Chemical\n-\tO\nconserving\tO\ndiuretic\tO\n(\tO\namiloride\tB-Chemical\n)\tO\nand\tO\na\tO\nsimilar\tO\nperiod\tO\non\tO\na\tO\npotassium\tB-Chemical\n-\tO\nlosing\tO\ndiuretic\tO\n(\tO\nchlorthalidone\tB-Chemical\n)\tO\nin\tO\na\tO\nrandomised\tO\nstudy\tO\n.\tO\n\nPlasma\tO\npotassium\tB-Chemical\nconcentrations\tO\nwere\tO\non\tO\naverage\tO\n1\tO\nmmol\tO\n/\tO\nL\tO\nlower\tO\nduring\tO\nthe\tO\nchlorthalidone\tB-Chemical\nphase\tO\ncompared\tO\nto\tO\namiloride\tB-Chemical\ntherapy\tO\n.\tO\n\nBlood\tO\npressure\tO\nand\tO\nvolume\tO\nstates\tO\nas\tO\nassessed\tO\nby\tO\nbodyweight\tO\n,\tO\nplasma\tO\nrenin\tO\nand\tO\nnoradrenaline\tB-Chemical\n(\tO\nnorepinephrine\tB-Chemical\n)\tO\nconcentrations\tO\nwere\tO\nsimilar\tO\non\tO\nthe\tO\n2\tO\nregimens\tO\n.\tO\n\nCompared\tO\nto\tO\namiloride\tB-Chemical\ntreatment\tO\n,\tO\nthe\tO\nchlorthalidone\tB-Chemical\nphase\tO\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nfrequency\tO\nof\tO\nventricular\tB-Disease\nectopic\tI-Disease\nbeats\tI-Disease\n(\tO\n24\tO\n-\tO\nhour\tO\nHolter\tO\nmonitoring\tO\n)\tO\nand\tO\na\tO\nhigher\tO\nLown\tO\ngrading\tO\n,\tO\nincreased\tO\nupslope\tO\nand\tO\nduration\tO\nof\tO\nthe\tO\nmonophasic\tO\naction\tO\npotential\tO\n,\tO\nprolonged\tO\nventricular\tO\neffective\tO\nrefractory\tO\nperiod\tO\n,\tO\nand\tO\nincreased\tO\nelectrical\tO\ninstability\tO\nduring\tO\nprogrammed\tO\nventricular\tO\nstimulation\tO\n.\tO\n\nThe\tO\nabove\tO\nresults\tO\nindicate\tO\nthat\tO\nbecause\tO\npotassium\tB-Chemical\n-\tO\nlosing\tO\ndiuretic\tO\ntherapy\tO\ncan\tO\nincrease\tO\nmyocardial\tO\nelectrical\tO\nexcitability\tO\nin\tO\npatients\tO\nwith\tO\nischaemic\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n,\tO\neven\tO\nminor\tO\nfalls\tO\nin\tO\nplasma\tO\npotassium\tB-Chemical\nconcentrations\tO\nare\tO\nprobably\tO\nbest\tO\navoided\tO\nin\tO\nsuch\tO\npatients\tO\n.\tO\n\nTransketolase\tO\nabnormality\tO\nin\tO\ntolazamide\tB-Chemical\n-\tO\ninduced\tO\nWernicke\tB-Disease\n'\tI-Disease\ns\tI-Disease\nencephalopathy\tI-Disease\n.\tO\n\nWe\tO\nstudied\tO\na\tO\nthiamine\tB-Chemical\n-\tO\ndependent\tO\nenzyme\tO\n,\tO\ntransketolase\tO\n,\tO\nfrom\tO\nfibroblasts\tO\nof\tO\na\tO\ndiabetic\tB-Disease\npatient\tO\nwho\tO\ndeveloped\tO\nWernicke\tB-Disease\n'\tI-Disease\ns\tI-Disease\nencephalopathy\tI-Disease\nwhen\tO\ntreated\tO\nwith\tO\ntolazamide\tB-Chemical\n,\tO\nin\tO\norder\tO\nto\tO\ndelineate\tO\nif\tO\nthis\tO\npatient\tO\nalso\tO\nhad\tO\ntransketolase\tO\nabnormality\tO\n[\tO\nhigh\tO\nKm\tO\nfor\tO\nthiamine\tB-Chemical\npyrophosphate\tI-Chemical\n(\tO\nTPP\tB-Chemical\n)\tO\n]\tO\n,\tO\nas\tO\npreviously\tO\nreported\tO\nin\tO\npostalcoholic\tO\nWernicke\tB-Disease\n-\tI-Disease\nKorsakoff\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nthis\tO\npatient\tO\n,\tO\nwe\tO\nalso\tO\nstudied\tO\nthis\tO\nenzyme\tO\nfrom\tO\nthree\tO\ndiabetic\tB-Disease\nkindreds\tO\nwithout\tO\nany\tO\nhistory\tO\nof\tO\nWernicke\tB-Disease\n'\tI-Disease\ns\tI-Disease\nencephalopathy\tI-Disease\nand\tO\nfrom\tO\nfour\tO\nnormal\tO\ncontrols\tO\n.\tO\n\nWe\tO\nfound\tO\nthat\tO\nthe\tO\nabove\tO\n-\tO\nmentioned\tO\npatient\tO\nand\tO\none\tO\nof\tO\nthe\tO\ndiabetic\tB-Disease\nkindreds\tO\nwith\tO\nno\tO\nhistory\tO\nof\tO\nWernicke\tB-Disease\n'\tI-Disease\ns\tI-Disease\nencephalopathy\tI-Disease\nhad\tO\nabnormal\tO\ntransketolase\tO\nas\tO\ndetermined\tO\nby\tO\nits\tO\nKm\tO\nfor\tO\nTPP\tB-Chemical\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\na\tO\nsimilarity\tO\nbetween\tO\npostalcoholic\tO\nWernicke\tB-Disease\n-\tI-Disease\nKorsakoff\tI-Disease\nsyndrome\tI-Disease\nand\tO\nthe\tO\npatient\tO\nwith\tO\ntolazamide\tB-Chemical\n-\tO\ninduced\tO\nWernicke\tB-Disease\n'\tI-Disease\ns\tI-Disease\nencephalopathy\tI-Disease\nfrom\tO\nthe\tO\nstandpoint\tO\nof\tO\ntransketolase\tO\nabnormality\tO\n.\tO\n\nBradycardia\tB-Disease\ndue\tO\nto\tO\ntrihexyphenidyl\tB-Chemical\nhydrochloride\tI-Chemical\n.\tO\n\nA\tO\nchronic\tO\nschizophrenic\tB-Disease\npatient\tO\nwas\tO\ntreated\tO\nwith\tO\nan\tO\nanticholinergic\tO\ndrug\tO\n,\tO\ntrihexyphenidyl\tB-Chemical\nhydrochloride\tI-Chemical\n.\tO\n\nThe\tO\npatient\tO\ndeveloped\tO\n,\tO\nparadoxically\tO\n,\tO\nsinus\tO\nbradycardia\tB-Disease\n.\tO\n\nThe\tO\nreaction\tO\nwas\tO\nspecific\tO\nto\tO\ntrihexyphenidyl\tB-Chemical\nand\tO\nnot\tO\nto\tO\nother\tO\nanticholinergic\tO\ndrugs\tO\n.\tO\n\nThis\tO\nantidyskinetic\tO\ndrug\tO\nis\tO\nwidely\tO\nused\tO\nin\tO\nclinical\tO\npsychiatric\tB-Disease\npractice\tO\nand\tO\nphysicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\nside\tO\neffect\tO\n.\tO\n\nPost\tO\n-\tO\noperative\tO\nrigidity\tB-Disease\nafter\tO\nfentanyl\tB-Chemical\nadministration\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nthoraco\tO\n-\tO\nabdominal\tO\nrigidity\tB-Disease\nleading\tO\nto\tO\nrespiratory\tB-Disease\nfailure\tI-Disease\nis\tO\ndescribed\tO\nin\tO\nthe\tO\npost\tO\n-\tO\noperative\tO\nperiod\tO\nin\tO\nan\tO\nelderly\tO\npatient\tO\nwho\tO\nreceived\tO\na\tO\nmoderate\tO\ndose\tO\nof\tO\nfentanyl\tB-Chemical\n.\tO\n\nThis\tO\nwas\tO\nsuccessfully\tO\nreversed\tO\nby\tO\nnaloxone\tB-Chemical\n.\tO\n\nThe\tO\nmechanisms\tO\npossibly\tO\nimplicated\tO\nin\tO\nthis\tO\naccident\tO\nare\tO\ndiscussed\tO\n.\tO\n\nAnti\tO\n-\tO\ncarcinogenic\tB-Disease\naction\tO\nof\tO\nphenobarbital\tB-Chemical\ngiven\tO\nsimultaneously\tO\nwith\tO\ndiethylnitrosamine\tB-Chemical\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nThe\tO\npresent\tO\nwork\tO\nhas\tO\nbeen\tO\nplanned\tO\nin\tO\norder\tO\nto\tO\nelucidate\tO\nthe\tO\neffect\tO\nof\tO\nphenobarbital\tB-Chemical\n(\tO\nPB\tB-Chemical\n:\tO\n15\tO\nmg\tO\nper\tO\nrat\tO\nof\tO\ningested\tO\ndose\tO\n)\tO\non\tO\ncarcinogenesis\tB-Disease\nwhen\tO\nit\tO\nis\tO\nadministered\tO\nsimultaneously\tO\nwith\tO\ndiethylnitrosamine\tB-Chemical\n(\tO\nDEN\tB-Chemical\n:\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n)\tO\n.\tO\n\nWistar\tO\nrats\tO\n(\tO\n180\tO\ng\tO\n)\tO\nwere\tO\ntreated\tO\nby\tO\nDEN\tB-Chemical\nalone\tO\nor\tO\nby\tO\nDEN\tB-Chemical\n+\tO\nPB\tB-Chemical\nduring\tO\n2\tO\n,\tO\n4\tO\nand\tO\n6\tO\nweeks\tO\naccording\tO\nto\tO\nour\tO\nschedule\tO\nfor\tO\nhepatocarcinogenesis\tB-Disease\n.\tO\n\nAfter\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\ntreatment\tO\n,\tO\nthe\tO\nnumber\tO\nand\tO\nthe\tO\nsize\tO\nof\tO\ninduced\tO\nPAS\tO\npositive\tO\npreneoplastic\tB-Disease\nfoci\tI-Disease\nwas\tO\nsignificantly\tO\nreduced\tO\nwhen\tO\nPB\tB-Chemical\nwas\tO\ngiven\tO\nsimultaneously\tO\nwith\tO\nDEN\tB-Chemical\nfor\tO\n4\tO\nand\tO\n6\tO\nweeks\tO\n.\tO\n\nThe\tO\nmitotic\tO\ninhibition\tO\nand\tO\nthe\tO\nproduction\tO\nof\tO\nmicronuclei\tO\nnormally\tO\nobserved\tO\nafter\tO\npartial\tO\nhepatectomy\tO\nin\tO\nDEN\tB-Chemical\ntreated\tO\nrats\tO\nwere\tO\nalso\tO\nsignificantly\tO\ndecreased\tO\nin\tO\nDEN\tB-Chemical\n+\tO\nPB\tB-Chemical\ntreated\tO\nrats\tO\n.\tO\n\nWhen\tO\nthe\tO\ntreatment\tO\nlast\tO\nonly\tO\n2\tO\nweeks\tO\n,\tO\nthe\tO\npresence\tO\nof\tO\nPB\tB-Chemical\ndid\tO\nnot\tO\nchange\tO\nsignificantly\tO\nthe\tO\nlast\tO\nparameters\tO\n.\tO\n\nIn\tO\nDEN\tB-Chemical\n+\tO\nPB\tB-Chemical\ntreated\tO\nrats\tO\n,\tO\nthe\tO\nsurvival\tO\nwas\tO\nprolonged\tO\nand\tO\nthe\tO\ntumor\tB-Disease\nincidence\tO\ndecreased\tO\nas\tO\ncompared\tO\nwith\tO\nthe\tO\nresults\tO\nobtained\tO\nby\tO\nDEN\tB-Chemical\nalone\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nPB\tB-Chemical\n,\tO\nwhich\tO\npromotes\tO\ncarcinogenesis\tB-Disease\nwhen\tO\nadministered\tO\nafter\tO\nthe\tO\nDEN\tB-Chemical\ntreatment\tO\n,\tO\nreduces\tO\nthe\tO\ncarcinogen\tO\neffect\tO\nwhen\tO\ngiven\tO\nsimultaneously\tO\nwith\tO\nDEN\tB-Chemical\n.\tO\n\nThis\tO\n'\tO\nanti\tO\n-\tO\ncarcinogen\tO\n'\tO\neffect\tO\nacts\tO\non\tO\nthe\tO\ninitiation\tO\nas\tO\nwell\tO\nas\tO\non\tO\nthe\tO\npromotion\tO\nof\tO\nthe\tO\nprecancerous\tB-Disease\nlesions\tI-Disease\n.\tO\n\nBiochemical\tO\ninvestigations\tO\nare\tO\nin\tO\nprogress\tO\nto\tO\nobtain\tO\nmore\tO\ninformation\tO\nabout\tO\nthis\tO\n'\tO\nparadoxical\tO\n'\tO\nPB\tB-Chemical\neffect\tO\n.\tO\n\nBilateral\tB-Disease\noptic\tI-Disease\nneuropathy\tI-Disease\ndue\tO\nto\tO\ncombined\tO\nethambutol\tB-Chemical\nand\tO\nisoniazid\tB-Chemical\ntreatment\tO\n.\tO\n\nThe\tO\ncase\tO\nof\tO\na\tO\n40\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\nwho\tO\nunderwent\tO\nan\tO\nunsuccessful\tO\ncadaver\tO\nkidney\tO\ntransplantation\tO\nand\tO\nwas\tO\ntreated\tO\nwith\tO\nethambutol\tB-Chemical\nand\tO\nisoniazid\tB-Chemical\nis\tO\nreported\tO\n.\tO\n\nA\tO\nbilateral\tB-Disease\nretrobulbar\tI-Disease\nneuropathy\tI-Disease\nwith\tO\nan\tO\nunusual\tO\ncentral\tO\nbitemporal\tO\nhemianopic\tO\nscotoma\tB-Disease\nwas\tO\nfound\tO\n.\tO\n\nEthambutol\tB-Chemical\nwas\tO\nstopped\tO\nand\tO\nonly\tO\nsmall\tO\nimprovement\tO\nof\tO\nthe\tO\nvisual\tO\nacuity\tO\nfollowed\tO\n.\tO\n\nIsoniazid\tB-Chemical\nwas\tO\ndiscontinued\tO\nlater\tO\n,\tO\nfollowed\tO\nby\tO\na\tO\ndramatic\tO\nimprovement\tO\nin\tO\nthe\tO\nvisual\tO\nacuity\tO\n.\tO\n\nThe\tO\nhazards\tO\nof\tO\noptic\tO\nnerve\tO\ntoxicity\tB-Disease\ndue\tO\nto\tO\nethambutol\tB-Chemical\nare\tO\nknown\tO\n.\tO\n\nWe\tO\nemphasize\tO\nthe\tO\npotential\tO\ndanger\tO\nin\tO\nthe\tO\nuse\tO\nof\tO\nethambutol\tB-Chemical\nand\tO\nisoniazid\tB-Chemical\n.\tO\n\nA\tO\nprospective\tO\nstudy\tO\nof\tO\nadverse\tO\nreactions\tO\nassociated\tO\nwith\tO\nvancomycin\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\nprospective\tO\nevaluation\tO\nof\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\nvancomycin\tB-Chemical\nwas\tO\nconducted\tO\nin\tO\n54\tO\nconsecutive\tO\npatients\tO\nover\tO\na\tO\n16\tO\n-\tO\nmonth\tO\nperiod\tO\n.\tO\n\nVancomycin\tB-Chemical\nwas\tO\ncurative\tO\nin\tO\n95\tO\n%\tO\nof\tO\n43\tO\npatients\tO\nwith\tO\nproven\tO\ninfection\tB-Disease\n.\tO\n\nDrugs\tO\nwere\tO\nceased\tO\nin\tO\nsix\tO\npatients\tO\nbecause\tO\nof\tO\nadverse\tO\nreactions\tO\n;\tO\nin\tO\nthree\tO\nof\tO\nthese\tO\nvancomycin\tB-Chemical\nwas\tO\nconsidered\tO\nthe\tO\nlikely\tO\ncause\tO\n.\tO\n\nReactions\tO\nincluded\tO\nthrombophlebitis\tB-Disease\n(\tO\n20\tO\nof\tO\n54\tO\npatients\tO\n)\tO\n,\tO\nrash\tB-Disease\n(\tO\n4\tO\nof\tO\n54\tO\n)\tO\n,\tO\nnephrotoxicity\tB-Disease\n(\tO\n4\tO\nof\tO\n50\tO\n)\tO\n,\tO\nproteinuria\tB-Disease\n(\tO\n1\tO\nof\tO\n50\tO\n)\tO\nand\tO\nototoxicity\tB-Disease\n(\tO\n1\tO\nof\tO\n11\tO\npatients\tO\ntested\tO\nby\tO\naudiometry\tO\n)\tO\n.\tO\n\nThrombophlebitis\tB-Disease\noccurred\tO\nonly\tO\nwith\tO\ninfusion\tO\nthrough\tO\nperipheral\tO\ncannulae\tO\n;\tO\nnephrotoxicity\tB-Disease\nand\tO\nototoxicity\tB-Disease\nwere\tO\nconfined\tO\nto\tO\npatients\tO\nreceiving\tO\nan\tO\naminoglycoside\tB-Chemical\nplus\tO\nvancomycin\tB-Chemical\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nvancomycin\tB-Chemical\n,\tO\nadministered\tO\nappropriately\tO\n,\tO\nconstitutes\tO\nsafe\tO\n,\tO\neffective\tO\ntherapy\tO\nfor\tO\ninfections\tB-Disease\ncaused\tO\nby\tO\nsusceptible\tO\nbacteria\tO\n.\tO\n\nFactors\tO\nassociated\tO\nwith\tO\nnephrotoxicity\tB-Disease\nand\tO\nclinical\tO\noutcome\tO\nin\tO\npatients\tO\nreceiving\tO\namikacin\tB-Chemical\n.\tO\n\nData\tO\nfrom\tO\n60\tO\npatients\tO\ntreated\tO\nwith\tO\namikacin\tB-Chemical\nwere\tO\nanalyzed\tO\nfor\tO\nfactors\tO\nassociated\tO\nwith\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nIn\tO\n42\tO\nof\tO\nthese\tO\npatients\tO\n,\tO\ndata\tO\nwere\tO\nexamined\tO\nfor\tO\nfactors\tO\nassociated\tO\nwith\tO\nclinical\tO\noutcome\tO\n.\tO\n\nVariables\tO\nevaluated\tO\nincluded\tO\npatient\tO\nweight\tO\n,\tO\nage\tO\n,\tO\nsex\tO\n,\tO\nserum\tO\ncreatinine\tB-Chemical\nlevel\tO\n,\tO\ncreatinine\tB-Chemical\nclearance\tO\n,\tO\nduration\tO\nof\tO\ntherapy\tO\n,\tO\ntotal\tO\ndose\tO\n,\tO\nmean\tO\ndaily\tO\ndose\tO\n,\tO\norganism\tO\nminimum\tO\ninhibitory\tO\nconcentration\tO\n(\tO\nMIC\tO\n)\tO\n,\tO\nmean\tO\npeak\tO\nlevels\tO\n,\tO\nmean\tO\ntrough\tO\nlevels\tO\n,\tO\nmean\tO\narea\tO\nunder\tO\nthe\tO\nserum\tO\nconcentration\tO\n-\tO\ntime\tO\ncurve\tO\n(\tO\nAUC\tO\n)\tO\n,\tO\ntotal\tO\nAUC\tO\n,\tO\nmean\tO\nAUC\tO\ngreater\tO\nthan\tO\nMIC\tO\n,\tO\ntotal\tO\nAUC\tO\ngreater\tO\nthan\tO\nMIC\tO\n,\tO\nmean\tO\nSchumacher\tO\n'\tO\ns\tO\nintensity\tO\nfactor\tO\n(\tO\nIF\tO\n)\tO\n,\tO\ntotal\tO\nIF\tO\n,\tO\nIn\tO\n(\tO\nmean\tO\nmaximum\tO\nconcentration\tO\n[\tO\nCmax\tO\n]\tO\n/\tO\nMIC\tO\n)\tO\n.\tO\n\nModel\tO\n-\tO\ndependent\tO\npharmacokinetic\tO\nparameters\tO\nwere\tO\ncalculated\tO\nby\tO\ncomputer\tO\nbased\tO\non\tO\na\tO\none\tO\n-\tO\ncompartment\tO\nmodel\tO\n.\tO\n\nWhen\tO\nthe\tO\nparameters\tO\nwere\tO\nexamined\tO\nindividually\tO\n,\tO\nduration\tO\nof\tO\ntherapy\tO\nand\tO\ntotal\tO\nAUC\tO\ncorrelated\tO\nsignificantly\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n05\tO\n)\tO\nwith\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\na\tO\nstepwise\tO\ndiscriminant\tO\nfunction\tO\nanalysis\tO\nidentified\tO\nonly\tO\nduration\tO\nof\tO\ntherapy\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n001\tO\n)\tO\nas\tO\nan\tO\nimportant\tO\nfactor\tO\n.\tO\n\nBased\tO\non\tO\nthis\tO\nmodel\tO\nand\tO\non\tO\nBayes\tO\n'\tO\ntheorem\tO\n,\tO\nthe\tO\npredictive\tO\naccuracy\tO\nof\tO\nidentifying\tO\n\"\tO\nnephrotoxic\tB-Disease\n\"\tO\npatients\tO\nincreased\tO\nfrom\tO\n0\tO\n.\tO\n17\tO\nto\tO\n0\tO\n.\tO\n39\tO\n.\tO\n\nWhen\tO\nexamined\tO\nindividually\tO\n,\tO\nmean\tO\nIF\tO\n,\tO\nMIC\tO\n,\tO\ntotal\tO\ndose\tO\n,\tO\nmean\tO\ndaily\tO\ndose\tO\n,\tO\nand\tO\nln\tO\n(\tO\nmean\tO\nCmax\tO\n/\tO\nMIC\tO\n)\tO\ncorrelated\tO\nsignificantly\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n05\tO\n)\tO\nwith\tO\ncure\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\na\tO\nsimultaneous\tO\nmultivariable\tO\nanalysis\tO\nidentified\tO\nIF\tO\n,\tO\nMIC\tO\n,\tO\nand\tO\ntotal\tO\ndose\tO\naccording\tO\nto\tO\none\tO\nmodel\tO\nand\tO\nln\tO\n(\tO\nmean\tO\nCmax\tO\n/\tO\nMIC\tO\n)\tO\naccording\tO\nto\tO\na\tO\nsecond\tO\nstatistical\tO\nmodel\tO\nof\tO\nparameters\tO\nselected\tO\nto\tO\nhave\tO\nthe\tO\ngreatest\tO\nprospective\tO\nvalue\tO\n.\tO\n\nBased\tO\non\tO\nBayes\tO\n'\tO\ntheorem\tO\nand\tO\nthe\tO\nfirst\tO\nmodel\tO\n,\tO\nthe\tO\npredictive\tO\naccuracy\tO\nof\tO\nidentifying\tO\npatients\tO\nnot\tO\ncured\tO\nincreased\tO\nfrom\tO\n0\tO\n.\tO\n19\tO\nto\tO\n0\tO\n.\tO\n83\tO\n.\tO\n\nFor\tO\nthe\tO\nsecond\tO\nmodel\tO\n,\tO\nthe\tO\npredictive\tO\naccuracy\tO\nincreased\tO\nfrom\tO\n0\tO\n.\tO\n19\tO\nto\tO\n0\tO\n.\tO\n50\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nCardiac\tB-Disease\ntoxicity\tI-Disease\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n.\tO\n\nReport\tO\nof\tO\na\tO\ncase\tO\nof\tO\nspontaneous\tO\nangina\tB-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\npatient\tO\nwith\tO\ncolon\tB-Disease\ncarcinoma\tI-Disease\nand\tO\nliver\tO\nmetastasis\tB-Disease\nwho\tO\npresented\tO\nchest\tB-Disease\npain\tI-Disease\nafter\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\nadministration\tO\n.\tO\n\nClinical\tO\nelectrocardiographic\tO\nevolution\tO\nwas\tO\nsimilar\tO\nto\tO\nthat\tO\nobserved\tO\nin\tO\nPrinzmetal\tB-Disease\n'\tI-Disease\ns\tI-Disease\nangina\tI-Disease\n,\tO\nand\tO\nchest\tB-Disease\npain\tI-Disease\npromptly\tO\nresolved\tO\nwith\tO\nnifedipine\tB-Chemical\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\ncoronary\tB-Disease\nspasm\tI-Disease\nmay\tO\nbe\tO\nthe\tO\ncause\tO\nof\tO\ncardiotoxicity\tB-Disease\ndue\tO\nto\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n,\tO\nand\tO\nthat\tO\ncalcium\tB-Chemical\nantagonists\tO\nmay\tO\nprobably\tO\nbe\tO\nused\tO\nin\tO\nthe\tO\nprevention\tO\nor\tO\ntreatment\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ncardiotoxicity\tB-Disease\n.\tO\n\nDose\tO\n-\tO\nrelated\tO\nbeneficial\tO\nand\tO\nadverse\tO\neffects\tO\nof\tO\ndietary\tO\ncorticosterone\tB-Chemical\non\tO\norganophosphorus\tB-Chemical\n-\tO\ninduced\tO\ndelayed\tO\nneuropathy\tB-Disease\nin\tO\nchickens\tO\n.\tO\n\nTri\tB-Chemical\n-\tI-Chemical\northo\tI-Chemical\n-\tI-Chemical\ntolyl\tI-Chemical\nphosphate\tI-Chemical\n(\tO\nTOTP\tB-Chemical\n)\tO\n,\tO\n360\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\npo\tO\n,\tO\nand\tO\n0\tB-Chemical\n,\tI-Chemical\n0\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\ndiisopropyl\tI-Chemical\nphosphorofluoridate\tI-Chemical\n(\tO\nDFP\tB-Chemical\n)\tO\n,\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n,\tO\nwere\tO\nadministered\tO\nto\tO\nadult\tO\nWhite\tO\nLeghorn\tO\nchickens\tO\n24\tO\nhr\tO\nafter\tO\nthey\tO\nwere\tO\nplaced\tO\non\tO\ndiets\tO\ncontaining\tO\n0\tO\nto\tO\n300\tO\nppm\tO\ncorticosterone\tB-Chemical\n.\tO\n\nSupplemented\tO\ndiets\tO\nwere\tO\ncontinued\tO\nuntil\tO\nclinical\tO\nsigns\tO\nand\tO\nlesions\tO\nof\tO\ndelayed\tO\nneuropathy\tB-Disease\nappeared\tO\n.\tO\n\nAlthough\tO\nlow\tO\nconcentrations\tO\n(\tO\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n50\tO\nppm\tO\n)\tO\nof\tO\ncorticosterone\tB-Chemical\nhad\tO\nbeneficial\tO\neffects\tO\non\tO\nTOTP\tB-Chemical\n-\tO\ninduced\tO\nneuropathy\tB-Disease\n,\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n200\tO\nppm\tO\nexacerbated\tO\nclinical\tO\nsigns\tO\nin\tO\nchickens\tO\ngiven\tO\neither\tO\nTOTP\tB-Chemical\nor\tO\nDFP\tB-Chemical\n.\tO\n\nNeurotoxic\tB-Disease\nesterase\tO\nactivities\tO\n24\tO\nhr\tO\nafter\tO\nTOTP\tB-Chemical\nor\tO\nDFP\tB-Chemical\nwere\tO\nless\tO\nthan\tO\n20\tO\n%\tO\nof\tO\nvalues\tO\nmeasured\tO\nin\tO\nchickens\tO\nnot\tO\ngiven\tO\norganophosphorous\tB-Chemical\ncompounds\tO\n.\tO\n\nChickens\tO\ngiven\tO\n200\tO\nppm\tO\ncorticosterone\tB-Chemical\nwithout\tO\nTOTP\tB-Chemical\nor\tO\nDFP\tB-Chemical\nhad\tO\nsignificantly\tO\nelevated\tO\nactivity\tO\nof\tO\nplasma\tO\ncholinesterase\tO\nand\tO\nsignificantly\tO\ninhibited\tO\nactivity\tO\nof\tO\nliver\tO\ncarboxylesterase\tO\n.\tO\n\nDegenerating\tB-Disease\nmyelinated\tI-Disease\nfibers\tI-Disease\nwere\tO\nalso\tO\nevident\tO\nin\tO\ndistal\tO\nlevels\tO\nof\tO\nthe\tO\nperipheral\tO\nnerves\tO\nof\tO\nchickens\tO\ngiven\tO\nTOTP\tB-Chemical\nor\tO\nDFP\tB-Chemical\n.\tO\n\nHepatotoxicity\tB-Disease\nof\tO\namiodarone\tB-Chemical\n.\tO\n\nAmiodarone\tB-Chemical\nhas\tO\nproved\tO\nvery\tO\neffective\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\notherwise\tO\nresistant\tO\ncardiac\tO\ntachyarrhythmias\tB-Disease\n.\tO\n\nThe\tO\nuse\tO\nof\tO\namiodarone\tB-Chemical\nhas\tO\n,\tO\nhowever\tO\n,\tO\nbeen\tO\nlimited\tO\ndue\tO\nto\tO\nits\tO\nserious\tO\nside\tO\n-\tO\neffects\tO\n.\tO\n\nA\tO\npatient\tO\nwith\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\ndue\tO\nto\tO\namiodarone\tB-Chemical\ntreatment\tO\nis\tO\npresented\tO\nbelow\tO\nand\tO\na\tO\nreview\tO\nof\tO\nthe\tO\nhepatotoxicity\tB-Disease\nof\tO\namiodarone\tB-Chemical\nis\tO\ngiven\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nsolid\tO\nevidence\tO\nexists\tO\nof\tO\nhepatic\tB-Disease\ninjury\tI-Disease\ndue\tO\nto\tO\namiodarone\tB-Chemical\ntreatment\tO\n,\tO\nincluding\tO\nsteatosis\tB-Disease\n,\tO\nalterations\tO\nresembling\tO\nalcoholic\tB-Disease\nhepatitis\tI-Disease\n,\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\nand\tO\nmicronodular\tO\ncirrhosis\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nliver\tI-Disease\n.\tO\n\nPatients\tO\nreceiving\tO\namiodarone\tB-Chemical\nshould\tO\nbe\tO\nregularly\tO\nscreened\tO\nwith\tO\nrespect\tO\nto\tO\nhepatic\tO\nenzyme\tO\nlevels\tO\n.\tO\n\nTherapy\tO\nshould\tO\nbe\tO\ndiscontinued\tO\non\tO\nthe\tO\nsuspicion\tO\nof\tO\ncholestatic\tB-Disease\ninjury\tI-Disease\nor\tO\nhepatomegaly\tB-Disease\n.\tO\n\nPromotional\tO\neffects\tO\nof\tO\ntestosterone\tB-Chemical\nand\tO\ndietary\tO\nfat\tO\non\tO\nprostate\tO\ncarcinogenesis\tB-Disease\nin\tO\ngenetically\tO\nsusceptible\tO\nrats\tO\n.\tO\n\nGermfree\tO\n(\tO\nGF\tO\n)\tO\nLobund\tO\nstrain\tO\nWistar\tO\n(\tO\nLW\tO\n)\tO\nrats\tO\n,\tO\nfed\tO\nvegetable\tO\ndiet\tO\nL\tO\n-\tO\n485\tO\n,\tO\nhave\tO\ndeveloped\tO\nprostate\tB-Disease\nadenocarcinomas\tI-Disease\nspontaneously\tO\n(\tO\n10\tO\n%\tO\nincidence\tO\n)\tO\nat\tO\naverage\tO\nage\tO\n34\tO\nmonths\tO\n.\tO\n\nConventional\tO\nLW\tO\nrats\tO\n,\tO\nimplanted\tO\nwith\tO\ntestosterone\tB-Chemical\nat\tO\nage\tO\n4\tO\nmonths\tO\n,\tO\ndeveloped\tO\na\tO\nhigher\tO\nincidence\tO\nof\tO\nprostate\tB-Disease\ncancer\tI-Disease\nafter\tO\nan\tO\naverage\tO\ninterval\tO\nof\tO\n14\tO\nmonths\tO\n:\tO\n24\tO\n%\tO\nhad\tO\ndeveloped\tO\ngross\tO\ntumors\tB-Disease\n,\tO\nand\tO\n40\tO\n%\tO\nwhen\tO\nit\tO\nincluded\tO\nmicroscopic\tO\ntumors\tB-Disease\n.\tO\n\nPreliminary\tO\nresults\tO\nindicate\tO\nthat\tO\ntestosterone\tB-Chemical\n-\tO\ntreated\tO\nLW\tO\nrats\tO\nthat\tO\nwere\tO\nfed\tO\nthe\tO\nsame\tO\ndiet\tO\n,\tO\nwhich\tO\nwas\tO\nsupplemented\tO\nwith\tO\ncorn\tO\noil\tO\nup\tO\nto\tO\n20\tO\n%\tO\nfat\tO\n,\tO\ndeveloped\tO\nprostate\tB-Disease\ncancer\tI-Disease\nafter\tO\nintervals\tO\nof\tO\n6\tO\n-\tO\n12\tO\nmonths\tO\n.\tO\n\nAged\tO\nGF\tO\nSprague\tO\n-\tO\nDawley\tO\n(\tO\nSD\tO\n)\tO\nrats\tO\nhave\tO\nnot\tO\ndeveloped\tO\nprostate\tB-Disease\ncancer\tI-Disease\nspontaneously\tO\n.\tO\n\nConventional\tO\nSD\tO\nrats\tO\nfed\tO\ndiet\tO\nL\tO\n-\tO\n485\tO\nand\tO\ntreated\tO\nwith\tO\ntestosterone\tB-Chemical\ndeveloped\tO\nonly\tO\nprostatitis\tB-Disease\n.\tO\n\nExperimental\tO\ndesigns\tO\nshould\tO\nconsider\tO\ngenetic\tO\nsusceptibility\tO\nas\tO\na\tO\nbasic\tO\nprerequisite\tO\nfor\tO\nstudies\tO\non\tO\nexperimental\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nTime\tO\ncourse\tO\nalterations\tO\nof\tO\nQTC\tO\ninterval\tO\ndue\tO\nto\tO\nhypaque\tB-Chemical\n76\tI-Chemical\n.\tO\n\nSequential\tO\nmeasurement\tO\nof\tO\nQT\tO\ninterval\tO\nduring\tO\nleft\tO\nventricular\tO\nangiography\tO\nwas\tO\nmade\tO\n30\tO\nseconds\tO\nand\tO\none\tO\n,\tO\nthree\tO\n,\tO\nfive\tO\nand\tO\nten\tO\nminutes\tO\nafter\tO\ninjection\tO\nof\tO\nhypaque\tB-Chemical\n76\tI-Chemical\n.\tO\n\nThe\tO\nsubjects\tO\nwere\tO\nten\tO\npatients\tO\nfound\tO\nto\tO\nhave\tO\nnormal\tO\nleft\tO\nventricles\tO\nand\tO\ncoronary\tO\narteries\tO\n.\tO\n\nSignificant\tO\nQTC\tB-Disease\nprolongation\tI-Disease\noccurred\tO\nin\tO\n30\tO\nseconds\tO\nto\tO\none\tO\nminute\tO\nin\tO\nassociation\tO\nwith\tO\nmarked\tO\nhypotension\tB-Disease\nand\tO\nelevation\tO\nof\tO\ncardiac\tO\noutput\tO\n.\tO\n\nRat\tO\nextraocular\tO\nmuscle\tO\nregeneration\tO\n.\tO\n\nRepair\tO\nof\tO\nlocal\tO\nanesthetic\tO\n-\tO\ninduced\tO\ndamage\tO\n.\tO\n\nLocal\tO\nanesthetics\tO\nthat\tO\nare\tO\ncommonly\tO\nused\tO\nin\tO\nophthalmic\tO\nsurgery\tO\n(\tO\n0\tO\n.\tO\n75\tO\n%\tO\nbupivacaine\tB-Chemical\nhydrochloride\tI-Chemical\n,\tO\n2\tO\n.\tO\n0\tO\n%\tO\nmepivacaine\tB-Chemical\nhydrochloride\tI-Chemical\n,\tO\nand\tO\n2\tO\n.\tO\n0\tO\n%\tO\nlidocaine\tB-Chemical\nhydrochloride\tI-Chemical\nplus\tO\n1\tO\n:\tO\n100\tO\n,\tO\n000\tO\nepinephrine\tB-Chemical\n)\tO\nwere\tO\ninjected\tO\ninto\tO\nthe\tO\nretrobulbar\tO\narea\tO\nof\tO\nrat\tO\neyes\tO\n.\tO\n\nControls\tO\nwere\tO\ninjected\tO\nwith\tO\nphysiological\tO\nsaline\tO\n.\tO\n\nAll\tO\nthree\tO\nanesthetics\tO\nproduced\tO\nmassive\tO\ndegeneration\tO\nof\tO\nthe\tO\nextraocular\tO\nmuscles\tO\n.\tO\n\nMuscle\tB-Disease\ndegeneration\tI-Disease\nis\tO\nfollowed\tO\nby\tO\nregeneration\tO\nof\tO\nthe\tO\ndamaged\tO\nmuscle\tO\nfibers\tO\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nmuscle\tB-Disease\ndamage\tI-Disease\n,\tO\nsevere\tO\ndamage\tO\nwas\tO\nalso\tO\nseen\tO\nin\tO\nharderian\tO\nglands\tO\n,\tO\nespecially\tO\nafter\tO\nexposure\tO\nto\tO\nmepivacaine\tB-Chemical\nand\tO\nlidocaine\tB-Chemical\nplus\tO\nepinephrine\tB-Chemical\n.\tO\n\nWith\tO\nthese\tO\nfindings\tO\nin\tO\nrats\tO\n,\tO\nit\tO\nis\tO\nhypothesized\tO\nthat\tO\nthe\tO\ntemporary\tO\ndiplopia\tB-Disease\nsometimes\tO\nseen\tO\nin\tO\npatients\tO\nafter\tO\nophthalmic\tO\nsurgery\tO\nmight\tO\nbe\tO\ndue\tO\nto\tO\nanesthetic\tO\n-\tO\ninduced\tO\ndamage\tO\nto\tO\nthe\tO\nextraocular\tO\nmuscles\tO\n.\tO\n\nGentamicin\tB-Chemical\nnephropathy\tB-Disease\nin\tO\na\tO\nneonate\tO\n.\tO\n\nThe\tO\nclinical\tO\nand\tO\nautopsy\tO\nfindings\tO\nin\tO\na\tO\npremature\tO\nbaby\tO\nwho\tO\ndied\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nafter\tO\ntherapy\tO\nwith\tO\ngentamicin\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n)\tO\nand\tO\npenicillin\tB-Chemical\nare\tO\npresented\tO\n.\tO\n\nThe\tO\nserum\tO\ngentamicin\tB-Chemical\nconcentration\tO\nhad\tO\nreached\tO\ntoxic\tO\nlevels\tO\nwhen\tO\nanuria\tB-Disease\ndeveloped\tO\n.\tO\n\nNumerous\tO\nperiodic\tB-Chemical\nacid\tI-Chemical\nSchiff\tO\n(\tO\nPAS\tO\n)\tO\npositive\tO\n,\tO\ndiastase\tO\nresistant\tO\ncytoplasmic\tO\ninclusion\tO\nbodies\tO\nwhich\tO\nappeared\tO\nas\tO\nmyelin\tO\nfigures\tO\nin\tO\ncytosegresomes\tO\nunder\tO\nthe\tO\nelectron\tO\nmicroscope\tO\nwere\tO\nidentified\tO\nin\tO\nthe\tO\nproximal\tO\nconvoluted\tO\ntubules\tO\n.\tO\n\nThe\tO\npathological\tO\nchanges\tO\ninduced\tO\nby\tO\ngentamicin\tB-Chemical\nin\tO\nthe\tO\nhuman\tO\nneonatal\tO\nkidneys\tO\nhave\tO\nnot\tO\nbeen\tO\npreviously\tO\nreported\tO\n.\tO\n\nInduction\tO\nby\tO\nparacetamol\tB-Chemical\nof\tO\nbladder\tB-Disease\nand\tI-Disease\nliver\tI-Disease\ntumours\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nEffects\tO\non\tO\nhepatocyte\tO\nfine\tO\nstructure\tO\n.\tO\n\nGroups\tO\nof\tO\nmale\tO\nand\tO\nfemale\tO\ninbred\tO\nLeeds\tO\nstrain\tO\nrats\tO\nwere\tO\nfed\tO\ndiets\tO\ncontaining\tO\neither\tO\n0\tO\n.\tO\n5\tO\n%\tO\nor\tO\n1\tO\n.\tO\n0\tO\n%\tO\nparacetamol\tB-Chemical\nby\tO\nweight\tO\nfor\tO\nup\tO\nto\tO\n18\tO\nmonths\tO\n.\tO\n\nAt\tO\nthe\tO\n1\tO\n.\tO\n0\tO\n%\tO\ndosage\tO\nlevel\tO\n,\tO\n20\tO\n%\tO\nof\tO\nrats\tO\nof\tO\nboth\tO\nsexes\tO\ndeveloped\tO\nneoplastic\tO\nnodules\tO\nof\tO\nthe\tO\nliver\tO\n,\tO\na\tO\nstatistically\tO\nsignificant\tO\nincidence\tO\n.\tO\n\nThese\tO\nrats\tO\nalso\tO\nshowed\tO\ngross\tO\nenlargement\tO\nof\tO\ntheir\tO\nlivers\tO\nand\tO\nan\tO\nincrease\tO\nin\tO\nfoci\tO\nof\tO\ncellular\tO\nalteration\tO\n,\tO\nthe\tO\nlatter\tO\nalso\tO\nbeing\tO\nobserved\tO\nin\tO\nthe\tO\nlow\tO\ndosage\tO\nmale\tO\nrats\tO\n.\tO\n\nPapillomas\tB-Disease\nof\tO\nthe\tO\ntransitional\tO\nepithelium\tO\nof\tO\nthe\tO\nbladder\tO\ndeveloped\tO\nin\tO\nall\tO\nparacetamol\tB-Chemical\n-\tO\ntreated\tO\ngroups\tO\n,\tO\nand\tO\nthree\tO\nrats\tO\nbore\tO\nbladder\tB-Disease\ncarcinomas\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nsignificant\tO\nyields\tO\nof\tO\nbladder\tB-Disease\ntumours\tI-Disease\nwere\tO\nonly\tO\nobtained\tO\nfrom\tO\nlow\tO\ndosage\tO\nfemales\tO\nand\tO\nhigh\tO\ndosage\tO\nmales\tO\n.\tO\n\nAdditionally\tO\n,\tO\n20\tO\nto\tO\n25\tO\n%\tO\nof\tO\nparacetamol\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\ndeveloped\tO\nhyperplasia\tB-Disease\nof\tO\nthe\tO\nbladder\tO\nepithelium\tO\n,\tO\nwhich\tO\nwas\tO\nnot\tO\ncoincident\tO\nwith\tO\nthe\tO\npresence\tO\nof\tO\nbladder\tB-Disease\ncalculi\tI-Disease\n.\tO\n\nA\tO\nlow\tO\nyield\tO\nof\tO\ntumours\tB-Disease\nat\tO\nvarious\tO\nother\tO\nsites\tO\nalso\tO\narose\tO\nfollowing\tO\nparacetamol\tB-Chemical\nfeeding\tO\n.\tO\n\nAn\tO\nelectron\tO\nmicroscope\tO\nstudy\tO\nof\tO\nthe\tO\nlivers\tO\nof\tO\nparacetamol\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nrevealed\tO\nultrastructural\tO\nchanges\tO\nin\tO\nthe\tO\nhepatocytes\tO\nthat\tO\nresemble\tO\nthose\tO\nthat\tO\nresult\tO\nfrom\tO\nexposure\tO\nto\tO\na\tO\nvariety\tO\nof\tO\nknown\tO\nhepatocarcinogens\tB-Disease\n.\tO\n\nTransient\tO\nhemiparesis\tB-Disease\n:\tO\na\tO\nrare\tO\nmanifestation\tO\nof\tO\ndiphenylhydantoin\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nReport\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nAmong\tO\nthe\tO\ncommon\tO\nside\tO\neffects\tO\nof\tO\ndiphenylhydantoin\tB-Chemical\n(\tO\nDPH\tB-Chemical\n)\tO\noverdose\tB-Disease\n,\tO\nthe\tO\nmost\tO\nfrequently\tO\nencountered\tO\nneurological\tO\nsigns\tO\nare\tO\nthose\tO\nof\tO\ncerebellar\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nVery\tO\nrarely\tO\n,\tO\nthe\tO\ntoxic\tO\nneurological\tO\nmanifestations\tO\nof\tO\nthis\tO\ndrug\tO\nare\tO\nof\tO\ncerebral\tO\norigin\tO\n.\tO\n\nTwo\tO\npatients\tO\nare\tO\npresented\tO\nwho\tO\nsuffered\tO\nprogressive\tO\nhemiparesis\tB-Disease\ndue\tO\nto\tO\nDPH\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nBoth\tO\nhad\tO\nbrain\tO\nsurgery\tO\nbefore\tO\nDPH\tB-Chemical\ntreatment\tO\n.\tO\n\nIt\tO\nis\tO\nassumed\tO\nthat\tO\npatients\tO\nwith\tO\nsome\tO\ncerebral\tB-Disease\ndamage\tI-Disease\nare\tO\nliable\tO\nto\tO\nmanifest\tO\nDPH\tB-Chemical\ntoxicity\tB-Disease\nas\tO\nfocal\tO\nneurological\tO\nsigns\tO\n.\tO\n\nTiapride\tB-Chemical\nin\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ninvoluntary\tB-Disease\nmovements\tI-Disease\n.\tO\n\nTiapride\tB-Chemical\n,\tO\na\tO\nsubstituted\tO\nbenzamide\tB-Chemical\nderivative\tO\nclosely\tO\nrelated\tO\nto\tO\nmetoclopramide\tB-Chemical\n,\tO\nreduced\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\npeak\tO\ndose\tO\ninvoluntary\tB-Disease\nmovements\tI-Disease\nin\tO\n16\tO\npatients\tO\nwith\tO\nidiopathic\tB-Disease\nParkinson\tI-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nan\tO\nunacceptable\tO\nincrease\tO\nin\tO\ndisability\tO\nfrom\tO\nParkinsonism\tB-Disease\nwith\tO\naggravation\tO\nof\tO\nend\tO\n-\tO\nof\tO\n-\tO\ndose\tO\nakinesia\tB-Disease\nled\tO\nto\tO\nits\tO\ncessation\tO\nin\tO\n14\tO\npatients\tO\n.\tO\n\nTiapride\tB-Chemical\nhad\tO\nno\tO\neffect\tO\non\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\nearly\tO\nmorning\tO\nof\tO\n\"\tO\noff\tO\n-\tO\nperiod\tO\n\"\tO\nsegmental\tO\ndystonia\tB-Disease\n.\tO\n\nThese\tO\nresults\tO\nfail\tO\nto\tO\nsupport\tO\nthe\tO\nnotion\tO\nthat\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nare\tO\ncaused\tO\nby\tO\noverstimulation\tO\nof\tO\na\tO\nseparate\tO\ngroup\tO\nof\tO\ndopamine\tB-Chemical\nreceptors\tO\n.\tO\n\nQuinidine\tB-Chemical\nhepatitis\tB-Disease\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nadministration\tO\nof\tO\nquinidine\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\npersistent\tO\nelevation\tO\nof\tO\nserum\tO\nconcentrations\tO\nof\tO\nSGOT\tO\n,\tO\nlactic\tB-Chemical\nacid\tI-Chemical\ndehydrogenase\tO\n,\tO\nand\tO\nalkaline\tO\nphosphatase\tO\n.\tO\n\nLiver\tO\nbiopsy\tO\nshowed\tO\nactive\tO\nhepatitis\tB-Disease\n.\tO\n\nDiscontinuance\tO\nof\tO\nquinidine\tB-Chemical\ntherapy\tO\nled\tO\nto\tO\nnormalization\tO\nof\tO\nliver\tO\nfunction\tO\ntests\tO\n.\tO\n\nA\tO\nchallenge\tO\ndose\tO\nof\tO\nquinidine\tB-Chemical\ncaused\tO\nclinical\tO\nsymptoms\tO\nand\tO\nabrupt\tO\nelevation\tO\nof\tO\nSGOT\tO\n,\tO\nalkaline\tO\nphosphatase\tO\n,\tO\nand\tO\nlactic\tB-Chemical\nacid\tI-Chemical\ndehydrogenase\tO\nvalues\tO\n.\tO\n\nWe\tO\nconcluded\tO\nthat\tO\nthis\tO\npatient\tO\nhad\tO\nquinidine\tB-Chemical\nhepatotoxicity\tB-Disease\nand\tO\nbelieve\tO\nthat\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\ncase\tO\nreported\tO\nwith\tO\nliver\tO\nbiopsy\tO\ndocumentation\tO\n.\tO\n\nThis\tO\nreport\tO\nalso\tO\nsuggests\tO\nthat\tO\n,\tO\neven\tO\nafter\tO\nlong\tO\n-\tO\nterm\tO\nadministration\tO\n,\tO\nthe\tO\nhepatic\tB-Disease\ntoxicity\tI-Disease\nis\tO\nreversible\tO\n.\tO\n\nArterial\tO\nthromboembolism\tB-Disease\nin\tO\npatients\tO\nreceiving\tO\nsystemic\tO\nheparin\tB-Chemical\ntherapy\tO\n:\tO\na\tO\ncomplication\tO\nassociated\tO\nwith\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n.\tO\n\nArterial\tO\nthromboembolism\tB-Disease\nis\tO\na\tO\nrecognized\tO\ncomplication\tO\nof\tO\nsystemic\tO\nheparin\tB-Chemical\ntherapy\tO\n.\tO\n\nCharacteristic\tO\nof\tO\nthe\tO\nentity\tO\nis\tO\narterial\tB-Disease\nocclusion\tI-Disease\nby\tO\nplatelet\tO\n-\tO\nfibrin\tO\nthrombi\tB-Disease\nwith\tO\ndistal\tO\nischemia\tB-Disease\noccurring\tO\nfour\tO\nto\tO\ntwenty\tO\ndays\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\nheparin\tB-Chemical\ntherapy\tO\n,\tO\npreceded\tO\nby\tO\nprofound\tO\nthrombocytopenia\tB-Disease\nwith\tO\nplatelet\tO\ncounts\tO\nin\tO\nthe\tO\nrange\tO\nof\tO\n30\tO\n,\tO\n000\tO\nto\tO\n40\tO\n,\tO\n000\tO\nper\tO\ncubic\tO\nmillimeter\tO\n.\tO\n\nThe\tO\nclinically\tO\napparent\tO\nocclusion\tO\nmay\tO\nbe\tO\npreceded\tO\nby\tO\ngastrointestinal\tB-Disease\nand\tI-Disease\nmusculoskeletal\tI-Disease\nsymptoms\tI-Disease\nthat\tO\nappear\tO\nto\tO\nbe\tO\nischemic\tB-Disease\nin\tO\norigin\tO\n,\tO\nand\tO\nmight\tO\nserve\tO\nto\tO\nwarn\tO\nthe\tO\nclinician\tO\nof\tO\nthese\tO\ncomplications\tO\n.\tO\n\nPrevious\tO\nreports\tO\nof\tO\nthese\tO\nphenomena\tO\nas\tO\nwell\tO\nas\tO\nrecent\tO\nstudies\tO\nof\tO\nthe\tO\neffect\tO\nof\tO\nheparin\tB-Chemical\nare\tO\nreviewed\tO\n.\tO\n\nThe\tO\ncommon\tO\nfactor\tO\nrelating\tO\nthromboembolism\tB-Disease\nand\tO\nthrombocytopenia\tB-Disease\nis\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nplatelet\tB-Disease\naggregation\tI-Disease\n.\tO\n\nAppropriate\tO\ntreatment\tO\nconsists\tO\nof\tO\ndiscontinuation\tO\nof\tO\nheparin\tB-Chemical\n,\tO\nand\tO\nanticoagulation\tO\nwith\tO\nsodium\tB-Chemical\nwarfarin\tI-Chemical\nif\tO\nnecessary\tO\n.\tO\n\nVascular\tO\nprocedures\tO\nare\tO\nperformed\tO\nas\tO\nindicated\tO\n.\tO\n\nPharmacology\tO\nof\tO\nGYKI\tB-Chemical\n-\tI-Chemical\n41\tI-Chemical\n099\tI-Chemical\n(\tO\nchlorpropanol\tB-Chemical\n,\tO\nTobanum\tB-Chemical\n)\tO\na\tO\nnew\tO\npotent\tO\nbeta\tO\n-\tO\nadrenergic\tO\nantagonist\tO\n.\tO\n\nThe\tO\ncompound\tO\nGYKI\tB-Chemical\n-\tI-Chemical\n41\tI-Chemical\n099\tI-Chemical\n,\tO\nas\tO\na\tO\nbeta\tO\n-\tO\nadrenergic\tO\nantagonist\tO\n,\tO\nis\tO\n3\tO\n-\tO\n8\tO\ntimes\tO\nmore\tO\npotent\tO\nthan\tO\npropranolol\tB-Chemical\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\n.\tO\n\nIts\tO\nantiarrhythmic\tO\neffectiveness\tO\nsurpasses\tO\nthat\tO\nof\tO\npropranolol\tB-Chemical\nand\tO\npindolol\tB-Chemical\ninhibiting\tO\nthe\tO\nouabain\tB-Chemical\narrhythmia\tB-Disease\nin\tO\ndogs\tO\nand\tO\ncats\tO\n.\tO\n\nGYKI\tB-Chemical\n-\tI-Chemical\n41\tI-Chemical\n900\tI-Chemical\nhas\tO\na\tO\nnegligible\tO\ncardiodepressant\tO\nactivity\tO\n;\tO\nit\tO\nis\tO\nnot\tO\ncardioselective\tO\n.\tO\n\nThe\tO\ncompound\tO\nshows\tO\na\tO\nrapid\tO\nand\tO\nlong\tO\nlasting\tO\neffect\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nprolonged\tO\nelimination\tO\nof\tO\nthe\tO\nradioactivity\tO\nafter\tO\nthe\tO\ninjection\tO\nof\tO\n14C\tB-Chemical\n-\tI-Chemical\n41\tI-Chemical\n099\tI-Chemical\nto\tO\nrats\tO\nand\tO\ndogs\tO\n.\tO\n\nThe\tO\nhalf\tO\nlife\tO\nof\tO\nthe\tO\nunlabeled\tO\nsubstance\tO\nin\tO\nhumans\tO\nwas\tO\nmore\tO\nthan\tO\n10\tO\nhours\tO\n.\tO\n\nAdverse\tO\nreactions\tO\nto\tO\nbendrofluazide\tB-Chemical\nand\tO\npropranolol\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nmild\tO\nhypertension\tB-Disease\n.\tO\n\nReport\tO\nof\tO\nMedical\tO\nResearch\tO\nCouncil\tO\nWorking\tO\nParty\tO\non\tO\nMild\tO\nto\tO\nModerate\tO\nHypertension\tB-Disease\n.\tO\n\nParticipants\tO\nin\tO\nthe\tO\nMedical\tO\nResearch\tO\nCouncil\tO\ntreatment\tO\ntrial\tO\nfor\tO\nmild\tO\nhypertension\tB-Disease\nare\tO\nrandomly\tO\nallocated\tO\nto\tO\none\tO\nof\tO\nfour\tO\ntreatment\tO\ngroups\tO\n:\tO\nbendrofluazide\tB-Chemical\n,\tO\npropranolol\tB-Chemical\n,\tO\nor\tO\na\tO\nplacebo\tO\nfor\tO\neither\tO\nof\tO\nthese\tO\ndrugs\tO\n.\tO\n\nThe\tO\ntrial\tO\nis\tO\nsingle\tO\n-\tO\nblind\tO\n.\tO\n\n23\tO\n582\tO\npatient\tO\n-\tO\nyears\tO\nof\tO\nobservation\tO\nhave\tO\nbeen\tO\ncompleted\tO\nso\tO\nfar\tO\n,\tO\n10\tO\n684\tO\non\tO\nactive\tO\ndrugs\tO\nand\tO\n12\tO\n898\tO\non\tO\nplacebos\tO\n.\tO\n\nThe\tO\nresults\tO\nshow\tO\nan\tO\nassociation\tO\nbetween\tO\nbendrofluazide\tB-Chemical\ntreatment\tO\nand\tO\nimpotence\tB-Disease\n,\tO\nand\tO\nimpotence\tB-Disease\nalso\tO\noccurred\tO\nmore\tO\nfrequently\tO\nin\tO\npatients\tO\ntaking\tO\npropranolol\tB-Chemical\nthan\tO\nin\tO\nthose\tO\ntaking\tO\nplacebos\tO\n.\tO\n\nOther\tO\nadverse\tO\nreactions\tO\nsignificantly\tO\nlinked\tO\nwith\tO\nactive\tO\ndrugs\tO\ninclude\tO\nimpaired\tB-Disease\nglucose\tI-Disease\ntolerance\tI-Disease\nin\tO\nmen\tO\nand\tO\nwomen\tO\nand\tO\ngout\tB-Disease\nin\tO\nmen\tO\n,\tO\nassociated\tO\nwith\tO\nbendrofluazide\tB-Chemical\ntreatment\tO\n,\tO\nand\tO\nRaynaud\tB-Disease\n'\tI-Disease\ns\tI-Disease\nphenomenon\tI-Disease\nand\tO\ndyspnoea\tB-Disease\nin\tO\nmen\tO\nand\tO\nwomen\tO\ntaking\tO\npropranolol\tB-Chemical\n.\tO\n\nNo\tO\ncorneal\tB-Disease\ndisease\tI-Disease\nis\tO\nknown\tO\nto\tO\nhave\tO\noccurred\tO\nin\tO\nthe\tO\npropranolol\tB-Chemical\ngroup\tO\n.\tO\n\nMean\tO\nserum\tO\npotassium\tB-Chemical\nlevel\tO\nfell\tO\n,\tO\nand\tO\nurea\tB-Chemical\nand\tO\nuric\tB-Chemical\nacid\tI-Chemical\nlevels\tO\nrose\tO\n,\tO\nin\tO\nmen\tO\nand\tO\nwomen\tO\ntaking\tO\nbendrofluazide\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\npropranolol\tB-Chemical\ngroup\tO\n,\tO\nserum\tO\npotassium\tB-Chemical\nand\tO\nuric\tB-Chemical\nacid\tI-Chemical\nlevels\tO\nrose\tO\nin\tO\nboth\tO\nsexes\tO\n,\tO\nbut\tO\nthe\tO\nurea\tB-Chemical\nlevel\tO\nrose\tO\nsignificantly\tO\nin\tO\nwomen\tO\nonly\tO\n.\tO\n\nSerotonergic\tO\ndrugs\tO\n,\tO\nbenzodiazepines\tB-Chemical\nand\tO\nbaclofen\tB-Chemical\nblock\tO\nmuscimol\tB-Chemical\n-\tO\ninduced\tO\nmyoclonic\tB-Disease\njerks\tI-Disease\nin\tO\na\tO\nstrain\tO\nof\tO\nmice\tO\n.\tO\n\nIn\tO\nmale\tO\nSwiss\tO\nmice\tO\n,\tO\nmuscimol\tB-Chemical\nproduced\tO\nmyoclonic\tB-Disease\njerks\tI-Disease\n.\tO\n\nA\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\ndose\tO\ninduced\tO\nthis\tO\nresponse\tO\nin\tO\nall\tO\nof\tO\nthe\tO\nmice\tO\ntested\tO\nand\tO\nthe\tO\npeak\tO\nresponse\tO\nof\tO\n73\tO\njerks\tO\nper\tO\nmin\tO\nwas\tO\nobserved\tO\nbetween\tO\n27\tO\nand\tO\n45\tO\nmin\tO\n.\tO\n\nIncreasing\tO\nthe\tO\nbrain\tO\nserotonin\tB-Chemical\nlevels\tO\nby\tO\nthe\tO\nadministration\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptophan\tI-Chemical\n(\tO\n80\tO\n-\tO\n160\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nin\tO\ncombination\tO\nwith\tO\na\tO\nperipheral\tO\ndecarboxylase\tO\ninhibitor\tO\nresulted\tO\nin\tO\nan\tO\ninhibition\tO\nof\tO\nthe\tO\nmuscimol\tB-Chemical\neffect\tO\n.\tO\n\nHowever\tO\n,\tO\nin\tO\na\tO\nsimilar\tO\nexperiment\tO\nl\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n(\tO\n80\tO\n-\tO\n160\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\nwithout\tO\neffect\tO\n.\tO\n\nIn\tO\ndoses\tO\nof\tO\n3\tO\n-\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nthe\tO\nserotonin\tB-Chemical\nreceptor\tO\nagonist\tO\nMK\tB-Chemical\n-\tI-Chemical\n212\tI-Chemical\ncaused\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nblockade\tO\nof\tO\nthe\tO\nresponse\tO\nof\tO\nmuscimol\tB-Chemical\n.\tO\n\nOf\tO\nthe\tO\nbenzodiazepines\tB-Chemical\n,\tO\nclonazepam\tB-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n0\tO\n.\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\nseveral\tO\nfold\tO\nmore\tO\npotent\tO\nthan\tO\ndiazepam\tB-Chemical\n(\tO\n0\tO\n.\tO\n3\tO\n-\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nin\tO\nblocking\tO\nthe\tO\nmyoclonic\tB-Disease\njerks\tI-Disease\n.\tO\n\nWhile\tO\n(\tO\n-\tO\n)\tO\n-\tO\nbaclofen\tB-Chemical\n(\tO\n1\tO\n-\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nproved\tO\nto\tO\nbe\tO\nan\tO\neffective\tO\nantagonist\tO\nof\tO\nmuscimol\tB-Chemical\n,\tO\nits\tO\n(\tO\n+\tO\n)\tO\n-\tO\nisomer\tO\n(\tO\n5\tO\n-\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nlacked\tO\nthis\tO\nproperty\tO\n.\tO\n\nConsidering\tO\nthe\tO\nfact\tO\nthat\tO\n5\tB-Chemical\n-\tI-Chemical\nHTP\tI-Chemical\nand\tO\nthe\tO\nbenzodiazepines\tB-Chemical\nhave\tO\nbeen\tO\nfound\tO\nto\tO\nbe\tO\nbeneficial\tO\nin\tO\nthe\tO\nmanagement\tO\nof\tO\nclinical\tO\nmyoclonus\tB-Disease\n,\tO\nthe\tO\nmuscimol\tB-Chemical\n-\tO\ninduced\tO\nmyoclonus\tB-Disease\nseems\tO\nto\tO\nbe\tO\na\tO\nsatisfactory\tO\nanimal\tO\nmodel\tO\nthat\tO\nmay\tO\nprove\tO\nuseful\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nnew\tO\ndrug\tO\ntreatments\tO\nfor\tO\nthis\tO\ncondition\tO\n.\tO\n\nOur\tO\npresent\tO\nstudy\tO\nindicated\tO\nthe\tO\npossible\tO\nvalue\tO\nof\tO\nMK\tB-Chemical\n-\tI-Chemical\n212\tI-Chemical\nand\tO\n(\tO\n-\tO\n)\tO\n-\tO\nbaclofen\tB-Chemical\nin\tO\nthe\tO\nmanagement\tO\nof\tO\nclinical\tO\nmyoclonus\tB-Disease\n.\tO\n\nAdverse\tO\ninteraction\tO\nbetween\tO\nbeta\tB-Chemical\n-\tI-Chemical\nadrenergic\tI-Chemical\nblocking\tI-Chemical\ndrugs\tI-Chemical\nand\tO\nverapamil\tB-Chemical\n-\tO\n-\tO\nreport\tO\nof\tO\nthree\tO\ncases\tO\n.\tO\n\nThree\tO\npatients\tO\nwith\tO\nischaemic\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\ndeveloped\tO\nprofound\tO\ncardiac\tB-Disease\nfailure\tI-Disease\n,\tO\nhypotension\tB-Disease\nand\tO\nbradycardia\tB-Disease\nduring\tO\ncombined\tO\ntherapy\tO\nwith\tO\nverapamil\tB-Chemical\nand\tO\nbeta\tB-Chemical\n-\tI-Chemical\nadrenergic\tI-Chemical\nblocking\tI-Chemical\ndrugs\tI-Chemical\n.\tO\n\nThis\tO\nclinical\tO\npicture\tO\nresolved\tO\ncompletely\tO\nwith\tO\ncessation\tO\nof\tO\nthe\tO\ncombined\tO\ntherapy\tO\n.\tO\n\nBaseline\tO\nleft\tO\nventricular\tO\nfunction\tO\n,\tO\nassessed\tO\nby\tO\ncardiac\tO\ncatheterisation\tO\nor\tO\nnuclear\tO\nangiography\tO\n,\tO\nwas\tO\nnormal\tO\nin\tO\ntwo\tO\npatients\tO\nand\tO\nonly\tO\nmildly\tO\nreduced\tO\nin\tO\nthe\tO\nother\tO\n.\tO\n\nSimultaneously\tO\nadministration\tO\nof\tO\nbeta\tB-Chemical\n-\tI-Chemical\nadrenergic\tI-Chemical\nblocking\tI-Chemical\ndrugs\tI-Chemical\nand\tO\nverapamil\tB-Chemical\nmay\tO\nresult\tO\nin\tO\nprofound\tO\nadverse\tO\ninteractions\tO\nand\tO\nshould\tO\nonly\tO\nbe\tO\nadministered\tO\nwith\tO\ngreat\tO\ncaution\tO\n.\tO\n\nComparison\tO\nof\tO\nthe\tO\neffectiveness\tO\nof\tO\nranitidine\tB-Chemical\nand\tO\ncimetidine\tB-Chemical\nin\tO\ninhibiting\tO\nacid\tO\nsecretion\tO\nin\tO\npatients\tO\nwith\tO\ngastric\tO\nhypersecretory\tO\nstates\tO\n.\tO\n\nThe\tO\nH2\tO\n-\tO\nhistamine\tB-Chemical\nreceptor\tO\nantagonists\tO\nranitidine\tB-Chemical\nand\tO\ncimetidine\tB-Chemical\nwere\tO\ncompared\tO\nfor\tO\ntheir\tO\nabilities\tO\nto\tO\ncontrol\tO\ngastric\tO\nacid\tO\nhypersecretion\tO\non\tO\na\tO\nshort\tO\n-\tO\nand\tO\nlong\tO\n-\tO\nterm\tO\nbasis\tO\nin\tO\n22\tO\npatients\tO\nwith\tO\ngastric\tO\nacid\tO\nhypersecretory\tO\nstates\tO\n.\tO\n\nNineteen\tO\npatients\tO\nhad\tO\nZollinger\tB-Disease\n-\tI-Disease\nEllison\tI-Disease\nsyndrome\tI-Disease\n,\tO\none\tO\npatient\tO\nhad\tO\nsystemic\tB-Disease\nmastocytosis\tI-Disease\n,\tO\nand\tO\ntwo\tO\npatients\tO\nhad\tO\nidiopathic\tO\nhypersecretion\tO\n.\tO\n\nThe\tO\nrates\tO\nof\tO\nonset\tO\nof\tO\nthe\tO\naction\tO\nof\tO\ncimetidine\tB-Chemical\nand\tO\nranitidine\tB-Chemical\nwere\tO\nthe\tO\nsame\tO\n.\tO\n\nThe\tO\nactions\tO\nof\tO\nboth\tO\ndrugs\tO\nwere\tO\nincreased\tO\nby\tO\nanticholinergic\tO\nagents\tO\n,\tO\nand\tO\nthere\tO\nwas\tO\na\tO\nclose\tO\ncorrelation\tO\nbetween\tO\nthe\tO\ndaily\tO\nmaintenance\tO\ndose\tO\nof\tO\neach\tO\ndrug\tO\nneeded\tO\nto\tO\ncontrol\tO\nacid\tO\nsecretion\tO\n.\tO\n\nHowever\tO\n,\tO\nranitidine\tB-Chemical\nwas\tO\nthreefold\tO\nmore\tO\npotent\tO\nthan\tO\ncimetidine\tB-Chemical\nboth\tO\nin\tO\nacute\tO\ninhibition\tO\nstudies\tO\nand\tO\nin\tO\nthe\tO\nmedian\tO\nmaintenance\tO\ndose\tO\nneeded\tO\n(\tO\n1\tO\n.\tO\n2\tO\ng\tO\nper\tO\nday\tO\nfor\tO\nranitidine\tB-Chemical\nand\tO\n3\tO\n.\tO\n6\tO\ng\tO\nper\tO\nday\tO\nfor\tO\ncimetidine\tB-Chemical\n)\tO\n.\tO\n\nSixty\tO\npercent\tO\nof\tO\nthe\tO\nmales\tO\ndeveloped\tO\nbreast\tO\nchanges\tO\nor\tO\nimpotence\tB-Disease\nwhile\tO\ntaking\tO\ncimetidine\tB-Chemical\nand\tO\nin\tO\nall\tO\ncases\tO\nthese\tO\nchanges\tO\ndisappeared\tO\nwhen\tO\ncimetidine\tB-Chemical\nwas\tO\nreplaced\tO\nby\tO\nranitidine\tB-Chemical\n.\tO\n\nTreatment\tO\nwith\tO\nhigh\tO\ndoses\tO\nof\tO\ncimetidine\tB-Chemical\n(\tO\none\tO\nto\tO\n60\tO\nmonths\tO\n;\tO\nmedian\tO\n,\tO\n11\tO\nmonths\tO\n)\tO\nor\tO\nranitidine\tB-Chemical\n(\tO\ntwo\tO\nto\tO\n31\tO\nmonths\tO\n;\tO\nmedian\tO\n,\tO\n14\tO\nmonths\tO\n)\tO\nwas\tO\nnot\tO\nassociated\tO\nwith\tO\nhepatic\tB-Disease\nor\tI-Disease\nhematologic\tI-Disease\ntoxicity\tI-Disease\nor\tO\nalterations\tO\nof\tO\nserum\tO\ngastrin\tO\nconcentrations\tO\n,\tO\nbut\tO\nranitidine\tB-Chemical\ntherapy\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nsignificantly\tO\nlower\tO\nserum\tO\ncreatinine\tB-Chemical\nlevel\tO\nthan\tO\nseen\tO\nwith\tO\ncimetidine\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\nresults\tO\nshow\tO\nthat\tO\nboth\tO\ndrugs\tO\ncan\tO\nadequately\tO\ninhibit\tO\nacid\tO\nsecretion\tO\nin\tO\npatients\tO\nwith\tO\ngastric\tO\nhypersecretory\tO\nstates\tO\n.\tO\n\nBoth\tO\nare\tO\nsafe\tO\nat\tO\nhigh\tO\ndoses\tO\n,\tO\nbut\tO\nranitidine\tB-Chemical\nis\tO\nthreefold\tO\nmore\tO\npotent\tO\nand\tO\ndoes\tO\nnot\tO\ncause\tO\nthe\tO\nantiandrogen\tO\nside\tO\neffects\tO\nfrequently\tO\nseen\tO\nwith\tO\nhigh\tO\ndoses\tO\nof\tO\ncimetidine\tB-Chemical\n.\tO\n\nEpileptogenic\tO\nproperties\tO\nof\tO\nenflurane\tB-Chemical\nand\tO\ntheir\tO\nclinical\tO\ninterpretation\tO\n.\tO\n\nThree\tO\ncases\tO\nof\tO\nEEG\tO\nchanges\tO\ninduced\tO\nby\tO\nsingle\tO\nexposure\tO\nto\tO\nenflurane\tB-Chemical\nanesthesia\tO\nare\tO\nreported\tO\n.\tO\n\nIn\tO\none\tO\npatient\tO\n,\tO\nenflurane\tB-Chemical\nadministered\tO\nduring\tO\na\tO\ndonor\tO\nnephrectomy\tO\nresulted\tO\nin\tO\nunexpected\tO\npartial\tO\nmotor\tO\nseizures\tB-Disease\n.\tO\n\nUntil\tO\nthe\tO\ncause\tO\nof\tO\nthe\tO\nseizures\tB-Disease\nwas\tO\ncorrectly\tO\nidentified\tO\n,\tO\nthe\tO\npatient\tO\nwas\tO\ninappropriately\tO\ntreated\tO\nwith\tO\nanticonvulsants\tO\n.\tO\n\nTwo\tO\nother\tO\npatients\tO\nsuffered\tO\nfrom\tO\npartial\tO\n,\tO\ncomplex\tO\nand\tO\ngeneralized\tO\nseizures\tB-Disease\nuncontrolled\tO\nby\tO\nmedication\tO\n.\tO\n\nEpileptic\tB-Disease\nfoci\tO\ndelineated\tO\nand\tO\nactivated\tO\nby\tO\nenflurane\tB-Chemical\nwere\tO\nsurgically\tO\nablated\tO\nand\tO\nthe\tO\npatients\tO\nare\tO\nnow\tO\nseizure\tB-Disease\n-\tO\nfree\tO\n.\tO\n\nPrevious\tO\nexposures\tO\nto\tO\nenflurane\tB-Chemical\nhave\tO\nto\tO\nbe\tO\ndisclosed\tO\nto\tO\navoid\tO\nmistakes\tO\nin\tO\nclinical\tO\ninterpretation\tO\nof\tO\nthe\tO\nEEG\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nenflurane\tB-Chemical\nmay\tO\nprove\tO\nto\tO\nbe\tO\na\tO\nsafe\tO\nfast\tO\nacting\tO\nactivator\tO\nof\tO\nepileptic\tB-Disease\nfoci\tO\nduring\tO\ncorticography\tO\nor\tO\ndepth\tO\nelectrode\tO\nintraoperative\tO\nrecordings\tO\n.\tO\n\nDevelopment\tO\nof\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\nwas\tO\nstudied\tO\nin\tO\nadult\tO\nfemale\tO\nWistar\tO\nrats\tO\nfollowing\tO\ndaily\tO\nsubcutaneous\tO\ninjections\tO\nof\tO\nisoproterenol\tB-Chemical\n(\tO\nISO\tB-Chemical\n)\tO\n(\tO\n0\tO\n.\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n)\tO\n.\tO\n\nA\tO\ntime\tO\ncourse\tO\nwas\tO\nestablished\tO\nfor\tO\nthe\tO\nchange\tO\nin\tO\ntissue\tO\nmass\tO\n,\tO\nRNA\tO\nand\tO\nDNA\tO\ncontent\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nhydroxyproline\tB-Chemical\ncontent\tO\n.\tO\n\nHeart\tO\nweight\tO\nincreased\tO\n44\tO\n%\tO\nafter\tO\n8\tO\ndays\tO\nof\tO\ntreatment\tO\nwith\tO\na\tO\nhalf\tO\ntime\tO\nof\tO\n3\tO\n.\tO\n4\tO\ndays\tO\n.\tO\n\nVentricular\tO\nRNA\tO\ncontent\tO\nwas\tO\nelevated\tO\n26\tO\n%\tO\nafter\tO\n24\tO\nh\tO\nof\tO\na\tO\nsingle\tO\ninjection\tO\nand\tO\nreached\tO\na\tO\nmaximal\tO\nlevel\tO\nfollowing\tO\n8\tO\ndays\tO\nof\tO\ntherapy\tO\n.\tO\n\nThe\tO\nhalf\tO\ntime\tO\nfor\tO\nRNA\tO\naccumulation\tO\nwas\tO\n2\tO\n.\tO\n0\tO\ndays\tO\n.\tO\n\nThe\tO\ntotal\tO\ncontent\tO\nof\tO\nhydroxyproline\tB-Chemical\nremained\tO\nstable\tO\nduring\tO\nthe\tO\nfirst\tO\n2\tO\ndays\tO\nof\tO\ntreatment\tO\nbut\tO\nincreased\tO\n46\tO\n%\tO\nafter\tO\n4\tO\ndays\tO\nof\tO\ntherapy\tO\n.\tO\n\nVentricular\tO\nDNA\tO\ncontent\tO\nwas\tO\nunchanged\tO\nduring\tO\nthe\tO\nearly\tO\nstage\tO\n(\tO\n1\tO\n-\tO\n4\tO\ndays\tO\n)\tO\nof\tO\nhypertrophic\tB-Disease\ngrowth\tO\nbut\tO\nincreased\tO\nto\tO\na\tO\nnew\tO\nsteady\tO\n-\tO\nstate\tO\nlevel\tO\n19\tO\n%\tO\nabove\tO\nthe\tO\ncontrols\tO\nafter\tO\n8\tO\ndays\tO\nof\tO\ntreatment\tO\n.\tO\n\nIntraventricular\tO\npressures\tO\nand\tO\ncoronary\tO\nflow\tO\nmeasures\tO\nwere\tO\nsimilar\tO\nfor\tO\ncontrol\tO\nand\tO\nexperimental\tO\nanimals\tO\nfollowing\tO\n4\tO\ndays\tO\nof\tO\ndeveloped\tO\nhypertrophy\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\ndP\tO\n/\tO\ndt\tO\nin\tO\nthe\tO\nISO\tB-Chemical\n-\tO\ntreated\tO\nhearts\tO\nwas\tO\nslightly\tO\nbut\tO\nsignificantly\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nelevated\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nthe\tO\nadaptive\tO\nresponse\tO\nto\tO\nISO\tB-Chemical\nshows\tO\nan\tO\nearly\tO\nhypertrophic\tB-Disease\nphase\tO\n(\tO\n1\tO\n-\tO\n4\tO\ndays\tO\n)\tO\ncharacterized\tO\nby\tO\na\tO\nsubstantial\tO\nincrease\tO\nin\tO\nRNA\tO\ncontent\tO\nand\tO\ncardiac\tO\nmass\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nchanges\tO\nin\tO\nDNA\tO\n.\tO\n\nHowever\tO\n,\tO\nprolonged\tO\nstimulation\tO\n(\tO\n8\tO\n-\tO\n12\tO\ndays\tO\n)\tO\nappears\tO\nto\tO\nrepresent\tO\na\tO\ncomplex\tO\nintegration\tO\nof\tO\nboth\tO\ncellular\tO\nhypertrophy\tB-Disease\nand\tO\nhyperplasia\tB-Disease\nwithin\tO\nthe\tO\nheart\tO\n.\tO\n\nMultiple\tO\nside\tO\neffects\tO\nof\tO\npenicillamine\tB-Chemical\ntherapy\tO\nin\tO\none\tO\npatient\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nSkin\tB-Disease\nrashes\tI-Disease\n,\tO\nproteinuria\tB-Disease\n,\tO\nsystemic\tB-Disease\nlupus\tI-Disease\nerythematosus\tI-Disease\n,\tO\npolymyositis\tB-Disease\nand\tO\nmyasthenia\tB-Disease\ngravis\tI-Disease\nhave\tO\nall\tO\nbeen\tO\nrecorded\tO\nas\tO\ncomplications\tO\nof\tO\npenicillamine\tB-Chemical\ntherapy\tO\nin\tO\npatients\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nA\tO\npatient\tO\nwho\tO\nhad\tO\ndeveloped\tO\nall\tO\n5\tO\nis\tO\nnow\tO\ndescribed\tO\n.\tO\n\nThe\tO\nskin\tB-Disease\nlesion\tI-Disease\nresembled\tO\nelastosis\tB-Disease\nperforans\tI-Disease\nserpiginosa\tI-Disease\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nreported\tO\nas\tO\na\tO\nrare\tO\nside\tO\neffect\tO\nin\tO\npatients\tO\nwith\tO\nWilson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nbut\tO\nnot\tO\nin\tO\npatients\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\ntreated\tO\nwith\tO\npenicillamine\tB-Chemical\n.\tO\n\nObsolete\tO\nbut\tO\ndangerous\tO\nantacid\tO\npreparations\tO\n.\tO\n\nOne\tO\ncase\tO\nof\tO\nacute\tO\nhypercalcaemia\tB-Disease\nand\tO\ntwo\tO\nof\tO\nrecurrent\tO\nnephrolithiasis\tB-Disease\nare\tO\nreported\tO\nin\tO\npatients\tO\nwho\tO\nhad\tO\nregularly\tO\nconsumed\tO\nlarge\tO\namounts\tO\nof\tO\ncalcium\tB-Chemical\ncarbon\tI-Chemical\n-\tI-Chemical\nate\tI-Chemical\n-\tO\nsodium\tB-Chemical\nbicarbonate\tI-Chemical\npowders\tO\nfor\tO\nmore\tO\nthan\tO\n20\tO\nyears\tO\n.\tO\n\nThe\tO\npowders\tO\nhad\tO\nbeen\tO\nobtained\tO\nfrom\tO\npharmacists\tO\nunknown\tO\nto\tO\nthe\tO\npatients\tO\n'\tO\nmedical\tO\npractitioners\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\nthese\tO\npreparations\tO\nwere\tO\nresponsible\tO\nfor\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nproblems\tO\n,\tO\nand\tO\nthat\tO\nsuch\tO\npowders\tO\nshould\tO\nno\tO\nlonger\tO\nbe\tO\nfreely\tO\nobtainable\tO\n.\tO\n\nDoxorubicin\tB-Chemical\ncardiomyopathy\tB-Disease\nin\tO\nchildren\tO\nwith\tO\nleft\tO\n-\tO\nsided\tO\nWilms\tB-Disease\ntumor\tI-Disease\n.\tO\n\nTwo\tO\nchildren\tO\nwith\tO\nWilms\tB-Disease\ntumor\tI-Disease\nof\tO\nthe\tO\nleft\tO\nkidney\tO\nexperienced\tO\nsevere\tO\nanthracycline\tB-Chemical\ncardiomyopathy\tB-Disease\nafter\tO\nirradiation\tO\nto\tO\nthe\tO\ntumor\tB-Disease\nbed\tO\nand\tO\nconventional\tO\ndosage\tO\nof\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nThe\tO\ncardiomyopathy\tB-Disease\nis\tO\nattributed\tO\n1\tO\n)\tO\nto\tO\nthe\tO\nfact\tO\nthat\tO\nradiation\tO\nfields\tO\nfor\tO\nleft\tO\nWilms\tB-Disease\ntumor\tI-Disease\ninclude\tO\nthe\tO\nlower\tO\nportion\tO\nof\tO\nthe\tO\nheart\tO\nand\tO\n2\tO\n)\tO\nto\tO\nthe\tO\ninteraction\tO\nof\tO\ndoxorubicin\tB-Chemical\nand\tO\nirradiation\tO\non\tO\ncardiac\tO\nmuscle\tO\n.\tO\n\nIt\tO\nis\tO\nrecommended\tO\nthat\tO\ndoxorubicin\tB-Chemical\ndosage\tO\nbe\tO\nsharply\tO\nrestricted\tO\nin\tO\nchildren\tO\nwith\tO\nWilms\tB-Disease\ntumor\tI-Disease\nof\tO\nthe\tO\nleft\tO\nkidney\tO\nwho\tO\nreceive\tO\npostoperative\tO\nirradiation\tO\n.\tO\n\nEffects\tO\nof\tO\ncalcitonin\tO\non\tO\nrat\tO\nextrapyramidal\tO\nmotor\tO\nsystem\tO\n:\tO\nbehavioral\tO\nand\tO\nbiochemical\tO\ndata\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ni\tO\n.\tO\nv\tO\n.\tO\nc\tO\n.\tO\ninjection\tO\nof\tO\nhuman\tO\nand\tO\nsalmon\tO\ncalcitonin\tO\non\tO\nbiochemical\tO\nand\tO\nbehavioral\tO\nparameters\tO\nrelated\tO\nto\tO\nthe\tO\nextrapyramidal\tO\nmotor\tO\nsystem\tO\n,\tO\nwere\tO\ninvestigated\tO\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nCalcitonin\tO\ninjection\tO\nresulted\tO\nin\tO\na\tO\npotentiation\tO\nof\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nand\tO\na\tO\npartial\tO\nprevention\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n.\tO\n\nMoreover\tO\ncalcitonin\tO\ninduced\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nnigral\tO\nGAD\tO\nactivity\tO\nbut\tO\nno\tO\nchange\tO\nin\tO\nstriatal\tO\nDA\tB-Chemical\nand\tO\nDOPAC\tB-Chemical\nconcentration\tO\nor\tO\nGAD\tO\nactivity\tO\n.\tO\n\nThe\tO\nresults\tO\nare\tO\ndiscussed\tO\nin\tO\nview\tO\nof\tO\na\tO\nprimary\tO\naction\tO\nof\tO\ncalcitonin\tO\non\tO\nthe\tO\nstriatonigral\tO\nGABAergic\tO\npathway\tO\nmediating\tO\nthe\tO\nDA\tB-Chemical\n-\tO\nrelated\tO\nbehavioral\tO\nmessages\tO\nof\tO\nstriatal\tO\norigin\tO\n.\tO\n\nNaloxazone\tB-Chemical\npretreatment\tO\nmodifies\tO\ncardiorespiratory\tO\n,\tO\ntemperature\tO\n,\tO\nand\tO\nbehavioral\tO\neffects\tO\nof\tO\nmorphine\tB-Chemical\n.\tO\n\nBehavioral\tO\nand\tO\ncardiorespiratory\tO\nresponses\tO\nto\tO\na\tO\nlethal\tO\ndose\tO\nof\tO\nmorphine\tB-Chemical\nwere\tO\nevaluated\tO\nin\tO\nrats\tO\npretreated\tO\nwith\tO\nsaline\tO\nor\tO\nnaloxazone\tB-Chemical\n,\tO\nan\tO\nantagonist\tO\nof\tO\nhigh\tO\n-\tO\naffinity\tO\nmu\tO\n1\tO\nopioid\tO\nreceptors\tO\n.\tO\n\nPretreatment\tO\nwith\tO\nnaloxazone\tB-Chemical\nsignificantly\tO\nblocked\tO\nmorphine\tB-Chemical\nanalgesia\tB-Disease\n,\tO\ncatalepsy\tB-Disease\nand\tO\nhypothermia\tB-Disease\nat\tO\na\tO\ndose\tO\nwhich\tO\ncompletely\tO\neliminated\tO\nhigh\tO\n-\tO\naffinity\tO\nbinding\tO\nin\tO\nbrain\tO\nmembranes\tO\n.\tO\n\nMoreover\tO\n,\tO\nnaloxazone\tB-Chemical\nsignificantly\tO\nattenuated\tO\nthe\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nand\tO\nrespiratory\tB-Disease\ndepression\tI-Disease\n,\tO\nwhereas\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nbradycardia\tB-Disease\nwas\tO\nless\tO\naffected\tO\n.\tO\n\nResults\tO\nindicate\tO\nthat\tO\nsubpopulations\tO\nof\tO\nmu\tO\nreceptors\tO\nmay\tO\nmediate\tO\nselective\tO\nbehavioral\tO\nand\tO\ncardiorespiratory\tO\nresponses\tO\nto\tO\nmorphine\tB-Chemical\n.\tO\n\nModification\tO\nof\tO\ndrug\tO\naction\tO\nby\tO\nhyperammonemia\tB-Disease\n.\tO\n\nPretreatment\tO\nwith\tO\nammonium\tB-Chemical\nacetate\tI-Chemical\n(\tO\nNH4Ac\tB-Chemical\n)\tO\n(\tO\n6\tO\nmmol\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\napproximately\tO\ndoubled\tO\nthe\tO\ntime\tO\nmorphine\tB-Chemical\n-\tO\ntreated\tO\nmice\tO\nremained\tO\non\tO\na\tO\nhot\tO\nsurface\tO\nand\tO\nsimilarly\tO\nincreased\tO\nmuscular\tO\nincoordination\tB-Disease\nby\tO\ndiazepam\tB-Chemical\n,\tO\nbut\tO\nNH4Ac\tB-Chemical\ntreatment\tO\nalone\tO\nhad\tO\nno\tO\neffect\tO\n.\tO\n\nThus\tO\n,\tO\nhyperammonemia\tB-Disease\nis\tO\ncapable\tO\nof\tO\naltering\tO\ndrug\tO\naction\tO\nand\tO\nmust\tO\nbe\tO\nconsidered\tO\nalong\tO\nwith\tO\nimpaired\tO\ndrug\tO\nmetabolism\tO\nin\tO\nenhanced\tO\ndrug\tO\nresponses\tO\nassociated\tO\nwith\tO\nliver\tB-Disease\ndisease\tI-Disease\n.\tO\n\nExperiments\tO\nin\tO\nvitro\tO\nshowed\tO\nthat\tO\nacetylcholine\tB-Chemical\n-\tO\ninduced\tO\ncatecholamine\tB-Chemical\nrelease\tO\nfrom\tO\nbovine\tO\nadrenal\tO\nmedulla\tO\nis\tO\ndepressed\tO\nas\tO\nmuch\tO\nas\tO\n50\tO\n%\tO\nby\tO\n0\tO\n.\tO\n3\tO\nmM\tO\nNH4Ac\tB-Chemical\nand\tO\nKCl\tB-Chemical\n-\tO\ninduced\tO\ncontractions\tO\nof\tO\nguinea\tO\n-\tO\npig\tO\nileum\tO\nwere\tO\ninhibited\tO\n20\tO\n%\tO\nby\tO\n5\tO\nmM\tO\nNH4Ac\tB-Chemical\n.\tO\n\nAddition\tO\nof\tO\nexcess\tO\ncalcium\tB-Chemical\nreversed\tO\nthe\tO\ndepression\tB-Disease\nin\tO\nboth\tO\ntissues\tO\n,\tO\nbut\tO\ncalcium\tB-Chemical\n-\tO\nindependent\tO\ncatecholamine\tB-Chemical\nrelease\tO\nby\tO\nacetaldehyde\tB-Chemical\nwas\tO\nnot\tO\nblocked\tO\nby\tO\nNH4Ac\tB-Chemical\n.\tO\n\nThese\tO\nresults\tO\nsuggested\tO\nthat\tO\nammonia\tB-Chemical\nblocks\tO\ncalcium\tB-Chemical\nchannels\tO\n.\tO\n\nParallels\tO\nin\tO\nthe\tO\nactions\tO\nof\tO\nNH4Ac\tB-Chemical\nand\tO\nthe\tO\ncalcium\tB-Chemical\nchannel\tO\nblocker\tO\nverapamil\tB-Chemical\nsupport\tO\nthis\tO\nconcept\tO\n.\tO\n\nBoth\tO\nverapamil\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nand\tO\nNH4Ac\tB-Chemical\npretreatment\tO\nenhanced\tO\nmorphine\tB-Chemical\nanalgesia\tB-Disease\n-\tO\nand\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\nmuscular\tO\nincoordination\tB-Disease\nand\tO\nantagonized\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nmotor\tO\nactivity\tO\n,\tO\nand\tO\nneither\tO\nverapamil\tB-Chemical\nnor\tO\nNH4Ac\tB-Chemical\naffected\tO\nthe\tO\nconvulsant\tO\naction\tO\nof\tO\nmetrazol\tB-Chemical\n.\tO\n\nThe\tO\ndata\tO\nsuggest\tO\nthat\tO\nhyperammonemia\tB-Disease\nexerts\tO\na\tO\ncalcium\tB-Chemical\nchannel\tO\nblocking\tO\naction\tO\nwhich\tO\nenhances\tO\nthe\tO\neffects\tO\nof\tO\ncentral\tO\nnervous\tO\nsystem\tO\ndepressants\tO\nand\tO\ncertain\tO\nopioid\tO\nanalgesics\tO\n.\tO\n\nLevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\nand\tO\nthalamotomy\tO\n.\tO\n\nLevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\nof\tO\nthe\tO\nlimbs\tO\nin\tO\nthirteen\tO\ncases\tO\nof\tO\nParkinsonism\tB-Disease\n,\tO\nwhich\tO\nwas\tO\nchoreic\tO\n,\tO\nballistic\tO\nor\tO\ndystonic\tB-Disease\nin\tO\ntype\tO\n,\tO\nwas\tO\nalleviated\tO\nalmost\tO\ncompletely\tO\nby\tO\nstereotaxic\tO\nsurgery\tO\nusing\tO\na\tO\nmicroelectrode\tO\ntechnique\tO\nfor\tO\nthe\tO\nventralis\tO\noralis\tO\nanterior\tO\nand\tO\nposterior\tO\nnuclei\tO\nof\tO\nthe\tO\nthalamus\tO\n,\tO\nbut\tO\nmuch\tO\nless\tO\nby\tO\nthe\tO\nventralis\tO\nintermedius\tO\nnucleus\tO\n.\tO\n\nControl\tO\nof\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nby\tO\nthalamic\tB-Disease\nlesions\tI-Disease\nin\tO\nthe\tO\ncourse\tO\nof\tO\nroutine\tO\ntreatment\tO\nof\tO\nParkinsonism\tB-Disease\nis\tO\ndiscussed\tO\n.\tO\n\nTreatment\tO\nof\tO\nifosfamide\tB-Chemical\n-\tO\ninduced\tO\nurothelial\tB-Disease\ntoxicity\tI-Disease\nby\tO\noral\tO\nadministration\tO\nof\tO\nsodium\tB-Chemical\n2\tI-Chemical\n-\tI-Chemical\nmercaptoethane\tI-Chemical\nsulphonate\tI-Chemical\n(\tO\nMESNA\tB-Chemical\n)\tO\nto\tO\npatients\tO\nwith\tO\ninoperable\tO\nlung\tB-Disease\ncancer\tI-Disease\n.\tO\n\nThe\tO\nprotective\tO\neffect\tO\nof\tO\noral\tO\nadministration\tO\nof\tO\nthe\tO\nthiol\tB-Chemical\ncompound\tO\nsodium\tB-Chemical\n2\tI-Chemical\n-\tI-Chemical\nmercaptoethane\tI-Chemical\nsulphonate\tI-Chemical\n(\tO\nMESNA\tB-Chemical\n)\tO\nagainst\tO\nurothelial\tB-Disease\ntoxicity\tI-Disease\ninduced\tO\nby\tO\nifosfamide\tB-Chemical\n(\tO\nIF\tB-Chemical\n)\tO\nwas\tO\ntested\tO\nin\tO\na\tO\ngroup\tO\nof\tO\n45\tO\npatients\tO\nwith\tO\ninoperable\tO\nlung\tB-Disease\ncancer\tI-Disease\nunder\tO\ntreatment\tO\nwith\tO\nIF\tB-Chemical\n(\tO\n2250\tO\nmg\tO\n/\tO\nm2\tO\non\tO\ndays\tO\n2\tO\n-\tO\n5\tO\n)\tO\nas\tO\npart\tO\nof\tO\na\tO\npolychemotherapy\tO\nregimen\tO\nrepeated\tO\nin\tO\na\tO\n4\tO\n-\tO\nweek\tO\ncycle\tO\n.\tO\n\nMESNA\tB-Chemical\nwas\tO\ngiven\tO\norally\tO\non\tO\nthe\tO\ndays\tO\nof\tO\ntreatment\tO\nwith\tO\nIF\tB-Chemical\nin\tO\n3\tO\ndoses\tO\nof\tO\n840\tO\nmg\tO\n/\tO\nm2\tO\n,\tO\neach\tO\nadministered\tO\nat\tO\n0\tO\nhr\tO\n(\tO\n=\tO\ninjection\tO\nof\tO\nIF\tB-Chemical\n)\tO\n,\tO\n4\tO\nhr\tO\nand\tO\n8\tO\nhr\tO\np\tO\n.\tO\ni\tO\n.\tO\n\nOut\tO\nof\tO\na\tO\ntotal\tO\nof\tO\n88\tO\ncourses\tO\nof\tO\nthis\tO\ntreatment\tO\nwe\tO\nobserved\tO\n10\tO\nepisodes\tO\nof\tO\nasymptomatic\tO\nmicroscopic\tO\nhaematuria\tB-Disease\nand\tO\nno\tO\nepisodes\tO\nof\tO\ngross\tO\nhaematuria\tB-Disease\n.\tO\n\nIn\tO\nthis\tO\ngroup\tO\nof\tO\n45\tO\npatients\tO\nunder\tO\nprotection\tO\nwith\tO\nMESNA\tB-Chemical\nthere\tO\nwere\tO\n5\tO\ncomplete\tO\nremissions\tO\nand\tO\n9\tO\npartial\tO\nremissions\tO\n(\tO\ntotal\tO\n31\tO\n%\tO\n)\tO\n.\tO\n\nA\tO\nfurther\tO\ngroup\tO\nof\tO\n25\tO\npatients\tO\nunder\tO\npolychemotherapy\tO\nwith\tO\nIF\tB-Chemical\nwere\tO\ntreated\tO\nby\tO\nconventional\tO\nprophylactic\tO\nmeasures\tO\n(\tO\nraised\tO\nfluid\tO\nintake\tO\nand\tO\nforced\tO\ndiuresis\tO\n)\tO\n.\tO\n\nIn\tO\nthis\tO\ngroup\tO\nthere\tO\nwere\tO\n1\tO\ncomplete\tO\nand\tO\n5\tO\npartial\tO\nremissions\tO\n(\tO\ntotal\tO\n24\tO\n%\tO\n)\tO\n,\tO\nbut\tO\nnearly\tO\nall\tO\npatients\tO\ndeveloped\tO\neither\tO\ngross\tO\nhaematuria\tB-Disease\nand\tO\n/\tO\nor\tO\nsymptoms\tO\nof\tO\nbladder\tB-Disease\nirritation\tI-Disease\n(\tO\ncystitis\tB-Disease\nand\tO\npollakisuria\tB-Disease\n)\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nappreciable\tO\ndifferences\tO\nbetween\tO\nthe\tO\nMESNA\tB-Chemical\nseries\tO\nand\tO\nthe\tO\nconventional\tO\nprophylaxis\tO\nseries\tO\nwith\tO\nrespect\tO\nto\tO\neither\tO\nhaematological\tO\nor\tO\nsystemic\tO\ntoxicity\tB-Disease\nof\tO\nthe\tO\ncytostatic\tO\ntreatment\tO\n.\tO\n\nOur\tO\nresults\tO\nsupport\tO\nthe\tO\nview\tO\nthat\tO\nMESNA\tB-Chemical\n,\tO\ngiven\tO\norally\tO\nin\tO\nconjunction\tO\nwith\tO\ncombined\tO\ncytostatic\tO\nregimens\tO\nwhich\tO\ninclude\tO\nIF\tB-Chemical\n,\tO\nsimplifies\tO\nthe\tO\ntreatment\tO\nand\tO\nprovides\tO\noptimum\tO\nprotection\tO\nfor\tO\nthe\tO\nurinary\tO\nepithelium\tO\n.\tO\n\nProtection\tO\nwith\tO\noral\tO\nMESNA\tB-Chemical\nis\tO\nparticularly\tO\nsuitable\tO\nfor\tO\noutpatients\tO\n.\tO\n\nMyoclonic\tB-Disease\n,\tI-Disease\natonic\tI-Disease\n,\tI-Disease\nand\tI-Disease\nabsence\tI-Disease\nseizures\tI-Disease\nfollowing\tO\ninstitution\tO\nof\tO\ncarbamazepine\tB-Chemical\ntherapy\tO\nin\tO\nchildren\tO\n.\tO\n\nFive\tO\nchildren\tO\n,\tO\naged\tO\n3\tO\nto\tO\n11\tO\nyears\tO\n,\tO\ntreated\tO\nwith\tO\ncarbamazepine\tB-Chemical\nfor\tO\nepilepsy\tB-Disease\n,\tO\nhad\tO\nan\tO\nacute\tO\naberrant\tO\nreaction\tO\ncharacterized\tO\nby\tO\nthe\tO\nonset\tO\nof\tO\nmyoclonic\tB-Disease\n,\tI-Disease\natypical\tI-Disease\nabsence\tI-Disease\nand\tI-Disease\n/\tI-Disease\nor\tI-Disease\natonic\tI-Disease\n(\tI-Disease\nminor\tI-Disease\nmotor\tI-Disease\n)\tI-Disease\nseizures\tI-Disease\nwithin\tO\na\tO\nfew\tO\ndays\tO\n.\tO\n\nWhen\tO\nthe\tO\ncarbamazepine\tB-Chemical\nwas\tO\ndiscontinued\tO\n,\tO\ntwo\tO\nof\tO\nthe\tO\nchildren\tO\nreturned\tO\nto\tO\ntheir\tO\nformer\tO\nstate\tO\nvery\tO\nquickly\tO\n,\tO\ntwo\tO\nhad\tO\nthe\tO\nminor\tO\nmotor\tO\nseizures\tB-Disease\nresolve\tO\nin\tO\n3\tO\nand\tO\n6\tO\nmonths\tO\n,\tO\nand\tO\none\tO\nhad\tO\nthe\tO\nseizures\tB-Disease\npersist\tO\n.\tO\n\nThe\tO\nchild\tO\nin\tO\nwhom\tO\nthe\tO\nseizures\tB-Disease\npersisted\tO\nwas\tO\nlater\tO\nfound\tO\nto\tO\nhave\tO\nceroid\tB-Disease\nlipofuscinosis\tI-Disease\n.\tO\n\nThe\tO\nother\tO\nchildren\tO\nare\tO\ndoing\tO\nwell\tO\non\tO\nother\tO\nanticonvulsants\tO\n.\tO\n\nEffect\tO\nof\tO\nprostaglandin\tB-Chemical\nsynthetase\tO\ninhibitors\tO\non\tO\nexperimentally\tO\ninduced\tO\nconvulsions\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nTo\tO\ninvestigate\tO\nthe\tO\nrelationship\tO\nof\tO\nprostaglandins\tB-Chemical\n(\tO\nPGs\tB-Chemical\n)\tO\nto\tO\nseizure\tB-Disease\ninduction\tO\n,\tO\nthe\tO\neffects\tO\nof\tO\nsix\tO\nPG\tO\nsynthetase\tO\ninhibitors\tO\non\tO\nconvulsions\tB-Disease\ninduced\tO\nby\tO\nflurothyl\tB-Chemical\n,\tO\npicrotoxin\tB-Chemical\n,\tO\npentetrazol\tB-Chemical\n(\tO\nPTZ\tB-Chemical\n)\tO\n,\tO\nelectroshock\tO\nor\tO\nbicuculline\tB-Chemical\nwere\tO\nevaluated\tO\n.\tO\n\nIbuprofen\tB-Chemical\n,\tO\nsulindac\tB-Chemical\n,\tO\nmefenamic\tB-Chemical\nacid\tI-Chemical\n,\tO\nand\tO\nlow\tO\ndose\tO\nmeclofenamic\tB-Chemical\nacid\tI-Chemical\nincreased\tO\nthe\tO\nlatency\tO\n-\tO\nto\tO\n-\tO\nonset\tO\nin\tO\nthe\tO\nflurothyl\tB-Chemical\nand\tO\n/\tO\nor\tO\nPTZ\tB-Chemical\nmodels\tO\n;\tO\nthe\tO\nelectroshock\tO\n,\tO\npicrotoxin\tB-Chemical\nand\tO\nbicuculline\tB-Chemical\nmodels\tO\nwere\tO\nnot\tO\nsignificantly\tO\naffected\tO\nby\tO\nany\tO\nof\tO\nthe\tO\npretreatment\tO\nagents\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nPGs\tB-Chemical\nare\tO\ninvolved\tO\nin\tO\nthe\tO\nmechanism\tO\n(\tO\ns\tO\n)\tO\nunderlying\tO\nfluorthyl\tB-Chemical\n-\tO\nand\tO\nPTZ\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n,\tO\nbut\tO\nnot\tO\npicrotoxin\tB-Chemical\n-\tO\n,\tO\nelectroshock\tO\n-\tO\n,\tO\nor\tO\nbicuculline\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nAcute\tO\nchanges\tO\nof\tO\nblood\tO\nammonia\tB-Chemical\nmay\tO\npredict\tO\nshort\tO\n-\tO\nterm\tO\nadverse\tO\neffects\tO\nof\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nValproic\tB-Chemical\nacid\tI-Chemical\n(\tO\nVPA\tB-Chemical\n)\tO\nwas\tO\ngiven\tO\nto\tO\n24\tO\nepileptic\tB-Disease\npatients\tO\nwho\tO\nwere\tO\nalready\tO\nbeing\tO\ntreated\tO\nwith\tO\nother\tO\nantiepileptic\tO\ndrugs\tO\n.\tO\n\nA\tO\nstandardized\tO\nloading\tO\ndose\tO\nof\tO\nVPA\tB-Chemical\nwas\tO\nadministered\tO\n,\tO\nand\tO\nvenous\tO\nblood\tO\nwas\tO\nsampled\tO\nat\tO\n0\tO\n,\tO\n1\tO\n,\tO\n2\tO\n,\tO\n3\tO\n,\tO\nand\tO\n4\tO\nhours\tO\n.\tO\n\nAmmonia\tB-Chemical\n(\tO\nNH3\tB-Chemical\n)\tO\nwas\tO\nhigher\tO\nin\tO\npatients\tO\nwho\tO\n,\tO\nduring\tO\ncontinuous\tO\ntherapy\tO\n,\tO\ncomplained\tO\nof\tO\ndrowsiness\tB-Disease\n(\tO\n7\tO\npatients\tO\n)\tO\nthan\tO\nin\tO\nthose\tO\nwho\tO\nwere\tO\nsymptom\tO\n-\tO\nfree\tO\n(\tO\n17\tO\npatients\tO\n)\tO\n,\tO\nalthough\tO\nVPA\tB-Chemical\nplasma\tO\nlevels\tO\nwere\tO\nsimilar\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nBy\tO\nmeasuring\tO\nVPA\tB-Chemical\n-\tO\ninduced\tO\nchanges\tO\nof\tO\nblood\tO\nNH3\tB-Chemical\ncontent\tO\n,\tO\nit\tO\nmay\tO\nbe\tO\npossible\tO\nto\tO\nidentify\tO\npatients\tO\nat\tO\nhigher\tO\nrisk\tO\nof\tO\nobtundation\tO\nwhen\tO\nVPA\tB-Chemical\nis\tO\ngiven\tO\nchronically\tO\n.\tO\n\nEffect\tO\nof\tO\ncaptopril\tB-Chemical\non\tO\npre\tO\n-\tO\nexisting\tO\nand\tO\naminonucleoside\tB-Chemical\n-\tO\ninduced\tO\nproteinuria\tB-Disease\nin\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n.\tO\n\nProteinuria\tB-Disease\nis\tO\na\tO\nside\tO\neffect\tO\nof\tO\ncaptopril\tB-Chemical\ntreatment\tO\nin\tO\nhypertensive\tB-Disease\npatients\tO\n.\tO\n\nThe\tO\npossibility\tO\nof\tO\nreproducing\tO\nthe\tO\nsame\tO\nrenal\tB-Disease\nabnormality\tI-Disease\nwith\tO\ncaptopril\tB-Chemical\nwas\tO\nexamined\tO\nin\tO\nSHR\tO\n.\tO\n\nOral\tO\nadministration\tO\nof\tO\ncaptopril\tB-Chemical\nat\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\nfor\tO\n14\tO\ndays\tO\nfailed\tO\nto\tO\naggravate\tO\nproteinuria\tB-Disease\npre\tO\n-\tO\nexisting\tO\nin\tO\nSHR\tO\n.\tO\n\nAlso\tO\n,\tO\ncaptopril\tB-Chemical\ntreatment\tO\nfailed\tO\nto\tO\npotentiate\tO\nor\tO\nfacilitate\tO\ndevelopment\tO\nof\tO\nmassive\tO\nproteinuria\tB-Disease\ninvoked\tO\nby\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nin\tO\nSHR\tO\n.\tO\n\nCaptopril\tB-Chemical\nhad\tO\nlittle\tO\nor\tO\nno\tO\ndemonstrable\tO\neffects\tO\non\tO\nserum\tO\nelectrolyte\tO\nconcentrations\tO\n,\tO\nexcretion\tO\nof\tO\nurine\tO\n,\tO\nsodium\tB-Chemical\nand\tO\npotassium\tB-Chemical\n,\tO\nendogenous\tO\ncreatinine\tB-Chemical\nclearance\tO\n,\tO\nbody\tO\nweight\tO\n,\tO\nand\tO\nfood\tO\nand\tO\nwater\tO\nconsumption\tO\n.\tO\n\nHowever\tO\n,\tO\nketone\tB-Chemical\nbodies\tO\nwere\tO\nconsistently\tO\npresent\tO\nin\tO\nurine\tO\nand\tO\nseveral\tO\nlethalities\tO\noccurred\tO\nduring\tO\nmultiple\tO\ndosing\tO\nof\tO\ncaptopril\tB-Chemical\nin\tO\nSHR\tO\n.\tO\n\nComplete\tO\nheart\tB-Disease\nblock\tI-Disease\nfollowing\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\ntrazodone\tB-Chemical\n.\tO\n\nForty\tO\nminutes\tO\nafter\tO\nreceiving\tO\na\tO\nsingle\tO\nstarting\tO\ndose\tO\nof\tO\ntrazodone\tB-Chemical\n,\tO\na\tO\npatient\tO\ndeveloped\tO\ncomplete\tO\nheart\tB-Disease\nblock\tI-Disease\n.\tO\n\nThe\tO\ncase\tO\nillustrates\tO\nthat\tO\n,\tO\ndespite\tO\nthe\tO\nresults\tO\nof\tO\nearlier\tO\nstudies\tO\n,\tO\ntrazodone\tB-Chemical\n'\tO\ns\tO\neffect\tO\non\tO\ncardiac\tO\nconduction\tO\nmay\tO\nbe\tO\nsevere\tO\nin\tO\nindividuals\tO\nat\tO\nrisk\tO\nfor\tO\nconduction\tO\ndelay\tO\n.\tO\n\nPhenobarbital\tB-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\nin\tO\na\tO\nneurologically\tB-Disease\n-\tI-Disease\nimpaired\tI-Disease\nchild\tO\n.\tO\n\nA\tO\n2\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nchild\tO\nwith\tO\nknown\tO\nneurologic\tB-Disease\nimpairment\tI-Disease\ndeveloped\tO\na\tO\ndyskinesia\tB-Disease\nsoon\tO\nafter\tO\nstarting\tO\nphenobarbital\tB-Chemical\ntherapy\tO\nfor\tO\nseizures\tB-Disease\n.\tO\n\nKnown\tO\ncauses\tO\nof\tO\nmovement\tB-Disease\ndisorders\tI-Disease\nwere\tO\neliminated\tO\nafter\tO\nevaluation\tO\n.\tO\n\nOn\tO\nrepeat\tO\nchallenge\tO\nwith\tO\nphenobarbital\tB-Chemical\n,\tO\nthe\tO\ndyskinesia\tB-Disease\nrecurred\tO\n.\tO\n\nPhenobarbital\tB-Chemical\nshould\tO\nbe\tO\nadded\tO\nto\tO\nthe\tO\nlist\tO\nof\tO\nanticonvulsant\tO\ndrugs\tO\nthat\tO\ncan\tO\ncause\tO\nmovement\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nEffects\tO\nof\tO\namine\tB-Chemical\npretreatment\tO\non\tO\nketamine\tB-Chemical\ncatatonia\tB-Disease\nin\tO\npinealectomized\tO\nor\tO\nhypophysectomized\tO\nanimals\tO\n.\tO\n\nThe\tO\npresent\tO\nstudies\tO\nwere\tO\ndesigned\tO\nto\tO\nclarify\tO\nthe\tO\nrole\tO\nof\tO\ncatecholamines\tB-Chemical\nand\tO\npineal\tO\nidolamines\tO\non\tO\nketamine\tB-Chemical\n-\tO\ninduced\tO\ncatatonia\tB-Disease\nin\tO\nthe\tO\nintact\tO\n,\tO\npinealectomized\tO\nor\tO\nhypophysectomized\tO\nchick\tO\nand\tO\nrat\tO\n.\tO\n\nIn\tO\nthe\tO\npinealectomized\tO\nchick\tO\n,\tO\npretreatment\tO\nwith\tO\ndopamine\tB-Chemical\nincreased\tO\nthe\tO\nduration\tO\nof\tO\ncatatonia\tB-Disease\n(\tO\nDOC\tO\n)\tO\nafter\tO\nketamine\tB-Chemical\n,\tO\nbut\tO\npretreatment\tO\nwith\tO\nnorepinephrine\tB-Chemical\ndid\tO\nnot\tO\n.\tO\n\nThe\tO\npineal\tO\nindolamines\tO\nexhibited\tO\nmixed\tO\nactions\tO\n.\tO\n\nSerotonin\tB-Chemical\nand\tO\nN\tB-Chemical\n-\tI-Chemical\nacetyl\tI-Chemical\nserotonin\tI-Chemical\nwhich\tO\naugmented\tO\nketamine\tB-Chemical\nDOC\tO\n,\tO\ndid\tO\nnot\tO\ndo\tO\nso\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nthe\tO\npineal\tO\ngland\tO\n,\tO\nwhereas\tO\nmelatonin\tB-Chemical\npotentiated\tO\nthe\tO\nketamine\tB-Chemical\nDOC\tO\nin\tO\nboth\tO\nthe\tO\nintact\tO\nand\tO\npinealectomized\tO\nchick\tO\n.\tO\n\nKetamine\tB-Chemical\nwas\tO\nmore\tO\npotent\tO\nin\tO\nthe\tO\nhypophysectomized\tO\nchick\tO\nand\tO\nthe\tO\ncircadian\tO\nrhythm\tO\nnoted\tO\nin\tO\nthe\tO\nintact\tO\nchick\tO\nwas\tO\nabsent\tO\n;\tO\nfurthermore\tO\n,\tO\nmelatonin\tB-Chemical\ndid\tO\nnot\tO\naugment\tO\nthe\tO\nketamine\tB-Chemical\nDOC\tO\nwhereas\tO\ndopamine\tB-Chemical\ncontinued\tO\nto\tO\ndo\tO\nso\tO\n.\tO\n\nThis\tO\nstudy\tO\ndid\tO\nnot\tO\ndemonstrate\tO\na\tO\nspecies\tO\ndifference\tO\nregarding\tO\nthe\tO\nrole\tO\nof\tO\nthe\tO\namines\tB-Chemical\non\tO\nthe\tO\npineal\tO\nin\tO\nspite\tO\nof\tO\nthe\tO\nimmature\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\nin\tO\nthe\tO\nyoung\tO\nchick\tO\nand\tO\nthe\tO\nintact\tO\nbarrier\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthese\tO\ndata\tO\nindicate\tO\na\tO\ndirect\tO\nrole\tO\nof\tO\nthe\tO\npituitary\tO\nin\tO\nthe\tO\naugmentation\tO\nof\tO\nketamine\tB-Chemical\nDOC\tO\ninduced\tO\nby\tO\nmelatonin\tB-Chemical\n.\tO\n\nFurthermore\tO\n,\tO\ndopamine\tB-Chemical\nappeared\tO\nto\tO\nact\tO\non\tO\nsystems\tO\nmore\tO\nclosely\tO\ninvolved\tO\nwith\tO\nthe\tO\ninduction\tO\nof\tO\nketamine\tB-Chemical\ncatatonia\tB-Disease\nrather\tO\nthan\tO\ndirectly\tO\non\tO\nthe\tO\npituitary\tO\n.\tO\n\nHeparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n,\tO\nthrombosis\tB-Disease\n,\tO\nand\tO\nhemorrhage\tB-Disease\n.\tO\n\nSixty\tO\n-\tO\ntwo\tO\npatients\tO\nwith\tO\na\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nare\tO\nreported\tO\n.\tO\n\nClinical\tO\nmanifestations\tO\nof\tO\nthis\tO\ndisorder\tO\ninclude\tO\nhemorrhage\tB-Disease\nor\tO\n,\tO\nmore\tO\nfrequently\tO\n,\tO\nthromboembolic\tB-Disease\nevents\tO\nin\tO\npatients\tO\nreceiving\tO\nheparin\tB-Chemical\n.\tO\n\nLaboratory\tO\ntesting\tO\nhas\tO\nrevealed\tO\na\tB-Disease\nfalling\tI-Disease\nplatelet\tI-Disease\ncount\tI-Disease\n,\tO\nincreased\tO\nresistance\tO\nto\tO\nheparin\tB-Chemical\n,\tO\nand\tO\naggregation\tO\nof\tO\nplatelets\tO\nby\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nplasma\tO\nwhen\tO\nheparin\tB-Chemical\nis\tO\nadded\tO\n.\tO\n\nImmunologic\tO\ntesting\tO\nhas\tO\ndemonstrated\tO\nthe\tO\npresence\tO\nof\tO\na\tO\nheparin\tB-Chemical\n-\tO\ndependent\tO\nplatelet\tO\nmembrane\tO\nantibody\tO\n.\tO\n\nThe\tO\n20\tO\ndeaths\tO\n,\tO\n52\tO\nhemorrhagic\tB-Disease\nand\tI-Disease\nthromboembolic\tI-Disease\ncomplications\tI-Disease\n,\tO\nand\tO\n21\tO\nsurgical\tO\nprocedures\tO\nto\tO\nmanage\tO\nthe\tO\ncomplications\tO\nconfirm\tO\nthe\tO\nseriousness\tO\nof\tO\nthe\tO\ndisorder\tO\n.\tO\n\nSpecific\tO\nrisk\tO\nfactors\tO\nhave\tO\nnot\tO\nbeen\tO\nidentified\tO\n;\tO\ntherefore\tO\n,\tO\nall\tO\npatients\tO\nreceiving\tO\nheparin\tB-Chemical\nshould\tO\nbe\tO\nmonitored\tO\n.\tO\n\nIf\tO\nthe\tO\nplatelet\tO\ncount\tO\nfalls\tO\nto\tO\nless\tO\nthan\tO\n100\tO\n,\tO\n000\tO\n/\tO\nmm3\tO\n,\tO\nwhile\tO\nthe\tO\npatient\tO\nis\tO\nreceiving\tO\nheparin\tB-Chemical\n,\tO\nplatelet\tB-Disease\naggregation\tI-Disease\ntesting\tO\n,\tO\nusing\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nplasma\tO\n,\tO\nis\tO\nindicated\tO\n.\tO\n\nManagement\tO\nconsists\tO\nof\tO\ncessation\tO\nof\tO\nheparin\tB-Chemical\n,\tO\nplatelet\tO\nanti\tO\n-\tO\naggregating\tO\nagents\tO\n,\tO\nand\tO\nalternate\tO\nforms\tO\nof\tO\nanticoagulation\tO\nwhen\tO\nindicated\tO\n.\tO\n\nVentricular\tB-Disease\nfibrillation\tI-Disease\nfrom\tO\ndiatrizoate\tB-Chemical\nwith\tO\nand\tO\nwithout\tO\nchelating\tO\nagents\tO\n.\tO\n\nThe\tO\ntoxicity\tB-Disease\nof\tO\nRenografin\tB-Chemical\n76\tI-Chemical\n%\tI-Chemical\nwas\tO\ncompared\tO\nwith\tO\nthat\tO\nof\tO\nHypaque\tB-Chemical\n76\tI-Chemical\n%\tI-Chemical\nby\tO\nselective\tO\ninjection\tO\nof\tO\neach\tO\ninto\tO\nthe\tO\nright\tO\ncoronary\tO\nartery\tO\nof\tO\ndogs\tO\n.\tO\n\nRenografin\tB-Chemical\ncontains\tO\nthe\tO\nchelating\tO\nagents\tO\nsodium\tB-Chemical\ncitrate\tI-Chemical\nand\tO\ndisodium\tB-Chemical\nedetate\tI-Chemical\n,\tO\nwhile\tO\nHypaque\tB-Chemical\ncontains\tO\ncalcium\tB-Chemical\ndisodium\tI-Chemical\nedetate\tI-Chemical\nand\tO\nno\tO\nsodium\tB-Chemical\ncitrate\tI-Chemical\n.\tO\n\nVentricular\tB-Disease\nfibrillation\tI-Disease\noccurred\tO\nsignificantly\tO\nmore\tO\noften\tO\nwith\tO\nRenografin\tB-Chemical\n,\tO\nsuggesting\tO\nthat\tO\nchelating\tO\nagents\tO\ncontribute\tO\nto\tO\ntoxicity\tB-Disease\nin\tO\ncoronary\tO\nangiography\tO\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nefficacy\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\nhigh\tO\n-\tO\ndose\tO\namiodarone\tB-Chemical\ntherapy\tO\nfor\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nor\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\n.\tO\n\nAmiodarone\tB-Chemical\nwas\tO\nadministered\tO\nto\tO\n154\tO\npatients\tO\nwho\tO\nhad\tO\nsustained\tO\n,\tO\nsymptomatic\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n(\tO\nVT\tB-Disease\n)\tO\n(\tO\nn\tO\n=\tO\n118\tO\n)\tO\nor\tO\na\tO\ncardiac\tB-Disease\narrest\tI-Disease\n(\tO\nn\tO\n=\tO\n36\tO\n)\tO\nand\tO\nwho\tO\nwere\tO\nrefractory\tO\nto\tO\nconventional\tO\nantiarrhythmic\tO\ndrugs\tO\n.\tO\n\nThe\tO\nloading\tO\ndose\tO\nwas\tO\n800\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\n6\tO\nweeks\tO\nand\tO\nthe\tO\nmaintenance\tO\ndose\tO\nwas\tO\n600\tO\nmg\tO\n/\tO\nday\tO\n.\tO\n\nSixty\tO\n-\tO\nnine\tO\npercent\tO\nof\tO\npatients\tO\ncontinued\tO\ntreatment\tO\nwith\tO\namiodarone\tB-Chemical\nand\tO\nhad\tO\nno\tO\nrecurrence\tO\nof\tO\nsymptomatic\tO\nVT\tB-Disease\nor\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\n(\tO\nVF\tB-Disease\n)\tO\nover\tO\na\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n6\tO\nto\tO\n52\tO\nmonths\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nstandard\tO\ndeviation\tO\n14\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n8\tO\n.\tO\n2\tO\n)\tO\n.\tO\n\nSix\tO\npercent\tO\nof\tO\nthe\tO\npatients\tO\nhad\tO\na\tO\nnonfatal\tO\nrecurrence\tO\nof\tO\nVT\tB-Disease\nand\tO\nwere\tO\nsuccessfully\tO\nmanaged\tO\nby\tO\ncontinuing\tO\namiodarone\tB-Chemical\nat\tO\na\tO\nhigher\tO\ndose\tO\nor\tO\nby\tO\nthe\tO\naddition\tO\nof\tO\na\tO\nconventional\tO\nantiarrhythmic\tO\ndrug\tO\n.\tO\n\nOne\tO\nor\tO\nmore\tO\nadverse\tO\ndrug\tO\nreactions\tO\noccurred\tO\nin\tO\n51\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nAdverse\tO\neffects\tO\nforced\tO\na\tO\nreduction\tO\nin\tO\nthe\tO\ndose\tO\nof\tO\namiodarone\tB-Chemical\nin\tO\n41\tO\n%\tO\nand\tO\ndiscontinuation\tO\nof\tO\namiodarone\tB-Chemical\nin\tO\n10\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nsymptomatic\tO\nadverse\tO\nreactions\tO\nwere\tO\ntremor\tB-Disease\nor\tO\nataxia\tB-Disease\n(\tO\n35\tO\n%\tO\n)\tO\n,\tO\nnausea\tB-Disease\nand\tO\nanorexia\tB-Disease\n(\tO\n8\tO\n%\tO\n)\tO\n,\tO\nvisual\tB-Disease\nhalos\tI-Disease\nor\tI-Disease\nblurring\tI-Disease\n(\tO\n6\tO\n%\tO\n)\tO\n,\tO\nthyroid\tB-Disease\nfunction\tI-Disease\nabnormalities\tI-Disease\n(\tO\n6\tO\n%\tO\n)\tO\nand\tO\npulmonary\tB-Disease\ninterstitial\tI-Disease\ninfiltrates\tI-Disease\n(\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nAlthough\tO\nlarge\tO\n-\tO\ndose\tO\namiodarone\tB-Chemical\nis\tO\nhighly\tO\neffective\tO\nin\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\ntreatment\tO\nof\tO\nVT\tB-Disease\nor\tO\nVF\tB-Disease\nrefractory\tO\nto\tO\nconventional\tO\nantiarrhythmic\tO\ndrugs\tO\n,\tO\nit\tO\ncauses\tO\nsignificant\tO\ntoxicity\tB-Disease\nin\tO\napproximately\tO\n50\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nHowever\tO\n,\tO\nwhen\tO\nthe\tO\ndose\tO\nis\tO\nadjusted\tO\nbased\tO\non\tO\nclinical\tO\nresponse\tO\nor\tO\nthe\tO\ndevelopment\tO\nof\tO\nadverse\tO\neffects\tO\n,\tO\n75\tO\n%\tO\nof\tO\npatients\tO\nwith\tO\nVT\tB-Disease\nor\tO\nVF\tB-Disease\ncan\tO\nbe\tO\nsuccessfully\tO\nmanaged\tO\nwith\tO\namiodarone\tB-Chemical\n.\tO\n\nWhy\tO\nmay\tO\nepsilon\tB-Chemical\n-\tI-Chemical\naminocaproic\tI-Chemical\nacid\tI-Chemical\n(\tO\nEACA\tB-Chemical\n)\tO\ninduce\tO\nmyopathy\tB-Disease\nin\tO\nman\tO\n?\tO\n\nReport\tO\nof\tO\na\tO\ncase\tO\nand\tO\nliterature\tO\nreview\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nnecrotizing\tB-Disease\nmyopathy\tI-Disease\ndue\tO\nto\tO\na\tO\nshort\tO\nepsilon\tB-Chemical\n-\tI-Chemical\naminocaproic\tI-Chemical\nacid\tI-Chemical\n(\tO\nEACA\tB-Chemical\n)\tO\ntreatment\tO\nin\tO\na\tO\n72\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\nwith\tO\nsubarachnoid\tB-Disease\nhaemorrhage\tI-Disease\n(\tO\nSAH\tB-Disease\n)\tO\nis\tO\ndescribed\tO\n.\tO\n\nPathogenetic\tO\nhypotheses\tO\nare\tO\ndiscussed\tO\n.\tO\n\nCerebral\tB-Disease\nhemorrhage\tI-Disease\nassociated\tO\nwith\tO\nphenylpropanolamine\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\ncaffeine\tB-Chemical\n.\tO\n\nPhenylpropanolamine\tB-Chemical\n(\tO\nPPA\tB-Chemical\n)\tO\nis\tO\na\tO\ndrug\tO\nthat\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nserious\tO\nside\tO\neffects\tO\nincluding\tO\nstroke\tB-Disease\n.\tO\n\nIt\tO\nis\tO\noften\tO\ncombined\tO\nwith\tO\ncaffeine\tB-Chemical\nin\tO\ndiet\tO\npreparations\tO\nand\tO\n\"\tO\nlook\tO\n-\tO\nalike\tO\n\"\tO\npills\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\ndetermine\tO\nif\tO\nPPA\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\ncan\tO\nlead\tO\nto\tO\nstroke\tB-Disease\nin\tO\nnormotensive\tO\nand\tO\n/\tO\nor\tO\nhypertensive\tB-Disease\nrats\tO\n,\tO\nwe\tO\nadministered\tO\nthe\tO\ncombination\tO\nin\tO\nsix\tO\ntimes\tO\nthe\tO\nallowed\tO\nhuman\tO\ndose\tO\ncalculated\tO\non\tO\na\tO\nper\tO\nweight\tO\nbasis\tO\nfor\tO\nthe\tO\nrats\tO\ntwo\tO\ntimes\tO\nper\tO\nday\tO\nfor\tO\nfive\tO\ndays\tO\n.\tO\n\nSubarachnoid\tB-Disease\nand\tI-Disease\ncerebral\tI-Disease\nhemorrhage\tI-Disease\nwas\tO\nnoted\tO\nin\tO\n18\tO\n%\tO\nof\tO\nthe\tO\nhypertensive\tB-Disease\nrats\tO\n.\tO\n\nA\tO\nsingle\tO\nPPA\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\nadministration\tO\n(\tO\nsame\tO\ndose\tO\n)\tO\nlead\tO\nto\tO\nacute\tO\nhypertension\tB-Disease\nin\tO\nboth\tO\nthe\tO\nnormotensive\tO\nand\tO\nhypertensive\tB-Disease\nanimals\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nPPA\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\ncan\tO\nlead\tO\nto\tO\ncerebral\tB-Disease\nhemorrhage\tI-Disease\nin\tO\npreviously\tO\nhypertensive\tB-Disease\nanimals\tO\nwhen\tO\nadministered\tO\nin\tO\ngreater\tO\nthan\tO\nthe\tO\nallowed\tO\ndosage\tO\n.\tO\n\nAn\tO\nacute\tO\nelevation\tO\nin\tO\nblood\tO\npressure\tO\nmay\tO\nbe\tO\na\tO\ncontributing\tO\nfactor\tO\n.\tO\n\nRenal\tB-Disease\npapillary\tI-Disease\nnecrosis\tI-Disease\ndue\tO\nto\tO\nnaproxen\tB-Chemical\n.\tO\n\nA\tO\n31\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n,\tO\nwho\tO\nhad\tO\npreviously\tO\nbeen\tO\ntreated\tO\nwith\tO\nsulindac\tB-Chemical\n,\tO\nfenoprofen\tB-Chemical\ncalcium\tI-Chemical\n,\tO\nhigh\tO\ndose\tO\nsalicylates\tB-Chemical\nand\tO\ngold\tB-Chemical\nsalts\tO\n,\tO\ndeveloped\tO\nrenal\tB-Disease\npapillary\tI-Disease\nnecrosis\tI-Disease\n(\tO\nRPN\tB-Disease\n)\tO\n4\tO\nmonths\tO\nafter\tO\ninstitution\tO\nof\tO\nnaproxen\tB-Chemical\ntherapy\tO\n.\tO\n\nNo\tO\nother\tO\nfactor\tO\npredisposing\tO\nto\tO\nRPN\tB-Disease\ncould\tO\nbe\tO\ndiscovered\tO\n.\tO\n\nSulindac\tB-Chemical\nwas\tO\nsubstituted\tO\nfor\tO\nnaproxen\tB-Chemical\nand\tO\nno\tO\nfurther\tO\nadverse\tO\nrenal\tO\neffects\tO\noccurred\tO\nover\tO\nthe\tO\nnext\tO\n12\tO\nmonths\tO\n.\tO\n\nWe\tO\nreview\tO\nprevious\tO\nreports\tO\nlinking\tO\nRPN\tB-Disease\nto\tO\nantiinflammatory\tO\ndrug\tO\nuse\tO\nand\tO\ndiscuss\tO\npossible\tO\nadvantages\tO\nof\tO\nsulindac\tB-Chemical\nin\tO\npatients\tO\nwho\tO\nhave\tO\nexperienced\tO\nrenal\tB-Disease\ntoxicity\tI-Disease\nfrom\tO\nother\tO\nantiinflammatory\tO\nagents\tO\n.\tO\n\nNephrotoxic\tB-Disease\neffects\tO\nof\tO\naminoglycoside\tB-Chemical\ntreatment\tO\non\tO\nrenal\tO\nprotein\tO\nreabsorption\tO\nand\tO\naccumulation\tO\n.\tO\n\nTo\tO\nquantify\tO\nthe\tO\neffects\tO\nof\tO\ngentamicin\tB-Chemical\n,\tO\nkanamycin\tB-Chemical\nand\tO\nnetilmicin\tB-Chemical\non\tO\nrenal\tO\nprotein\tO\nreabsorption\tO\nand\tO\naccumulation\tO\n,\tO\nthese\tO\ndrugs\tO\nwere\tO\nadministered\tO\nto\tO\nrats\tO\nintraperitoneally\tO\n(\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n)\tO\nfor\tO\n7\tO\n,\tO\n14\tO\nor\tO\n21\tO\ndays\tO\n.\tO\n\nScanning\tO\nelectron\tO\nmicroscopy\tO\nof\tO\nthe\tO\nglomerular\tO\nendothelia\tO\n,\tO\nurinary\tO\nmeasurements\tO\nof\tO\nsodium\tB-Chemical\n,\tO\npotassium\tB-Chemical\n,\tO\nendogenous\tO\nlysozyme\tO\n,\tO\nN\tO\n-\tO\nacetyl\tO\n-\tO\nbeta\tO\n-\tO\nD\tO\n-\tO\nglucosaminidase\tO\n(\tO\nNAG\tO\n)\tO\nas\tO\nwell\tO\nas\tO\nclearance\tO\nand\tO\naccumulation\tO\nexperiments\tO\nafter\tO\ni\tO\n.\tO\nv\tO\n.\tO\nadministration\tO\nof\tO\negg\tO\n-\tO\nwhite\tO\nlysozyme\tO\nand\tO\nmeasurements\tO\nof\tO\ninulin\tO\nclearance\tO\n(\tO\nGFR\tO\n)\tO\nwere\tO\ndone\tO\nin\tO\neach\tO\ntreatment\tO\ngroup\tO\n.\tO\n\nGentamicin\tB-Chemical\nadministration\tO\ndecreased\tO\ndiameter\tO\n,\tO\ndensity\tO\nand\tO\nshape\tO\nof\tO\nendothelial\tO\nfenestrae\tO\n.\tO\n\nKanamycin\tB-Chemical\nand\tO\nnetilmicin\tB-Chemical\nappeared\tO\nto\tO\nhave\tO\nno\tO\neffect\tO\nat\tO\nthe\tO\ndose\tO\nused\tO\n.\tO\n\nAll\tO\nthree\tO\naminoglycosides\tB-Chemical\ndecreased\tO\nGFR\tO\nand\tO\nincreased\tO\nurinary\tO\nexcretion\tO\nof\tO\nsodium\tB-Chemical\nand\tO\npotassium\tB-Chemical\n.\tO\n\nWhile\tO\ngentamicin\tB-Chemical\nand\tO\nkanamycin\tB-Chemical\ndecreased\tO\nthe\tO\npercentage\tO\nreabsorption\tO\nand\tO\naccumulation\tO\nof\tO\nlysozyme\tO\nafter\tO\ni\tO\n.\tO\nv\tO\n.\tO\nadministration\tO\nof\tO\negg\tO\n-\tO\nwhite\tO\nlysozyme\tO\nnetilmicin\tB-Chemical\nhad\tO\nno\tO\neffect\tO\n.\tO\n\nDaily\tO\nexcretion\tO\nof\tO\ntotal\tO\nprotein\tO\n,\tO\nendogenous\tO\nlysozyme\tO\nand\tO\nNAG\tO\nincreased\tO\nonly\tO\nafter\tO\ntreatment\tO\nwith\tO\nkanamycin\tB-Chemical\nand\tO\ngentamicin\tB-Chemical\n.\tO\n\nThus\tO\n,\tO\naminoglycosides\tB-Chemical\nmay\tO\nact\tO\nas\tO\nnephrotoxicants\tO\nat\tO\nglomerular\tO\nand\tO\n/\tO\nor\tO\ntubular\tO\nlevel\tO\ninducing\tO\nimpairment\tB-Disease\nof\tI-Disease\nrenal\tI-Disease\nreabsorption\tI-Disease\nand\tO\naccumulation\tO\nof\tO\nproteins\tO\n.\tO\n\nInduction\tO\nof\tO\nthe\tO\nobstructive\tB-Disease\nsleep\tI-Disease\napnea\tI-Disease\nsyndrome\tI-Disease\nin\tO\na\tO\nwoman\tO\nby\tO\nexogenous\tO\nandrogen\tB-Chemical\nadministration\tO\n.\tO\n\nWe\tO\ndocumented\tO\nairway\tO\nocclusion\tO\nduring\tO\nsleep\tO\nand\tO\nan\tO\nabnormally\tO\nhigh\tO\nsupraglottic\tO\nresistance\tO\nwhile\tO\nawake\tO\nin\tO\na\tO\n54\tO\n-\tO\nyr\tO\n-\tO\nold\tO\nwoman\tO\nwho\tO\nhad\tO\ndeveloped\tO\nphysical\tO\nchanges\tO\nand\tO\nthe\tO\nsyndrome\tB-Disease\nof\tI-Disease\nobstructive\tI-Disease\nsleep\tI-Disease\napnea\tI-Disease\nwhile\tO\nbeing\tO\nadministered\tO\nexogenous\tO\nandrogens\tB-Chemical\n.\tO\n\nWhen\tO\nthe\tO\nandrogens\tB-Chemical\nwere\tO\nwithdrawn\tO\n,\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nphysical\tO\nchanges\tO\n,\tO\nsymptoms\tO\n,\tO\nsleep\tO\nstudy\tO\n,\tO\nand\tO\nsupraglottic\tO\nresistance\tO\nall\tO\nreturned\tO\nto\tO\nnormal\tO\n.\tO\n\nA\tO\nrechallenge\tO\nwith\tO\nandrogen\tB-Chemical\nproduced\tO\nsymptoms\tO\nof\tO\nobstructive\tB-Disease\nsleep\tI-Disease\napnea\tI-Disease\nthat\tO\nabated\tO\nupon\tO\nwithdrawal\tO\nof\tO\nthe\tO\nhormone\tO\n.\tO\n\nPrevious\tO\nreports\tO\nhave\tO\nfavored\tO\na\tO\nrole\tO\nof\tO\nandrogens\tB-Chemical\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nsleep\tB-Disease\napnea\tI-Disease\n.\tO\n\nOur\tO\nreport\tO\nprovides\tO\ndirect\tO\nevidence\tO\nfor\tO\nthis\tO\nrole\tO\n.\tO\n\nStructural\tO\nand\tO\nfunctional\tO\nmeasurements\tO\nindicate\tO\nthat\tO\nandrogens\tB-Chemical\nexert\tO\na\tO\npermissive\tO\nor\tO\nnecessary\tO\naction\tO\non\tO\nthe\tO\nstructural\tO\nconfiguration\tO\nof\tO\nthe\tO\noropharynx\tO\nthat\tO\npredisposes\tO\nto\tO\nobstruction\tO\nduring\tO\nsleep\tO\n.\tO\n\nDevelopment\tO\nof\tO\nthe\tO\nobstructive\tB-Disease\nsleep\tI-Disease\napnea\tI-Disease\nsyndrome\tI-Disease\nmust\tO\nbe\tO\nconsidered\tO\na\tO\npossible\tO\nside\tO\neffect\tO\nof\tO\nandrogen\tB-Chemical\ntherapy\tO\n.\tO\n\nCardiotoxic\tB-Disease\nand\tO\npossible\tO\nleukemogenic\tO\neffects\tO\nof\tO\nadriamycin\tB-Chemical\nin\tO\nnonhuman\tO\nprimates\tO\n.\tO\n\n10\tO\nmonkeys\tO\n(\tO\nmacaques\tO\n)\tO\nreceived\tO\nadriamycin\tB-Chemical\nby\tO\nmonthly\tO\nintravenous\tO\ninjections\tO\nat\tO\n12\tO\nmg\tO\n/\tO\nm2\tO\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\n8\tO\nof\tO\nthe\tO\n10\tO\nmonkeys\tO\ndeveloped\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\nat\tO\nan\tO\naverage\tO\ncumulative\tO\nadriamycin\tB-Chemical\ndose\tO\n(\tO\n310\tO\nmg\tO\n/\tO\nm2\tO\n)\tO\nwell\tO\nbelow\tO\nthat\tO\nconsidered\tO\nthe\tO\nsafe\tO\nupper\tO\nlimit\tO\n(\tO\n550\tO\nmg\tO\n/\tO\nm2\tO\n)\tO\nin\tO\nman\tO\n.\tO\n\nHistologically\tO\n,\tO\nthe\tO\nmyocardial\tB-Disease\nlesions\tI-Disease\nresembled\tO\nthose\tO\nfound\tO\nin\tO\nhuman\tO\nanthracycline\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\n.\tO\n\n1\tO\nof\tO\nthe\tO\n10\tO\nmonkeys\tO\ndeveloped\tO\nacute\tB-Disease\nmyeloblastic\tI-Disease\nleukemia\tI-Disease\nafter\tO\nreceiving\tO\n324\tO\nmg\tO\n/\tO\nm2\tO\nof\tO\nadriamycin\tB-Chemical\n;\tO\nthe\tO\n10th\tO\nmonkey\tO\nis\tO\nalive\tO\nand\tO\nwell\tO\n26\tO\nmonths\tO\nafter\tO\nthe\tO\nlast\tO\ndose\tO\nof\tO\ndrug\tO\n.\tO\n\nOur\tO\nresults\tO\nsuggest\tO\nthat\tO\nadriamycin\tB-Chemical\nis\tO\na\tO\nmore\tO\npotent\tO\ncardiotoxin\tO\nin\tO\nmonkeys\tO\nthan\tO\nin\tO\nman\tO\n,\tO\nand\tO\nthat\tO\nleukemia\tB-Disease\nmay\tO\nbe\tO\na\tO\nconsequence\tO\nof\tO\nprolonged\tO\ntreatment\tO\nwith\tO\nthis\tO\ndrug\tO\n.\tO\n\nTricuspid\tB-Disease\nvalve\tI-Disease\nregurgitation\tI-Disease\nand\tO\nlithium\tB-Chemical\ncarbonate\tI-Chemical\ntoxicity\tB-Disease\nin\tO\na\tO\nnewborn\tO\ninfant\tO\n.\tO\n\nA\tO\nnewborn\tO\nwith\tO\nmassive\tO\ntricuspid\tB-Disease\nregurgitation\tI-Disease\n,\tO\natrial\tB-Disease\nflutter\tI-Disease\n,\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n,\tO\nand\tO\na\tO\nhigh\tO\nserum\tO\nlithium\tB-Chemical\nlevel\tO\nis\tO\ndescribed\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\npatient\tO\nto\tO\ninitially\tO\nmanifest\tO\ntricuspid\tB-Disease\nregurgitation\tI-Disease\nand\tO\natrial\tB-Disease\nflutter\tI-Disease\n,\tO\nand\tO\nthe\tO\n11th\tO\ndescribed\tO\npatient\tO\nwith\tO\ncardiac\tB-Disease\ndisease\tI-Disease\namong\tO\ninfants\tO\nexposed\tO\nto\tO\nlithium\tB-Chemical\ncompounds\tO\nin\tO\nthe\tO\nfirst\tO\ntrimester\tO\nof\tO\npregnancy\tO\n.\tO\n\nSixty\tO\n-\tO\nthree\tO\npercent\tO\nof\tO\nthese\tO\ninfants\tO\nhad\tO\ntricuspid\tO\nvalve\tO\ninvolvement\tO\n.\tO\n\nLithium\tB-Chemical\ncarbonate\tI-Chemical\nmay\tO\nbe\tO\na\tO\nfactor\tO\nin\tO\nthe\tO\nincreasing\tO\nincidence\tO\nof\tO\ncongenital\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\nwhen\tO\ntaken\tO\nduring\tO\nearly\tO\npregnancy\tO\n.\tO\n\nIt\tO\nalso\tO\ncauses\tO\nneurologic\tB-Disease\ndepression\tI-Disease\n,\tO\ncyanosis\tB-Disease\n,\tO\nand\tO\ncardiac\tB-Disease\narrhythmia\tI-Disease\nwhen\tO\nconsumed\tO\nprior\tO\nto\tO\ndelivery\tO\n.\tO\n\nEffects\tO\nof\tO\nthe\tO\nnovel\tO\ncompound\tO\naniracetam\tB-Chemical\n(\tO\nRo\tB-Chemical\n13\tI-Chemical\n-\tI-Chemical\n5057\tI-Chemical\n)\tO\nupon\tO\nimpaired\tB-Disease\nlearning\tI-Disease\nand\tI-Disease\nmemory\tI-Disease\nin\tO\nrodents\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\naniracetam\tB-Chemical\n(\tO\nRo\tB-Chemical\n13\tI-Chemical\n-\tI-Chemical\n5057\tI-Chemical\n,\tO\n1\tB-Chemical\n-\tI-Chemical\nanisoyl\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\npyrrolidinone\tI-Chemical\n)\tO\nwas\tO\nstudied\tO\non\tO\nvarious\tO\nforms\tO\nof\tO\nexperimentally\tO\nimpaired\tB-Disease\ncognitive\tI-Disease\nfunctions\tI-Disease\n(\tO\nlearning\tO\nand\tO\nmemory\tO\n)\tO\nin\tO\nrodents\tO\nand\tO\nproduced\tO\nthe\tO\nfollowing\tO\neffects\tO\n:\tO\n(\tO\n1\tO\n)\tO\nalmost\tO\ncomplete\tO\nprevention\tO\nof\tO\nthe\tO\nincapacity\tO\nto\tO\nlearn\tO\na\tO\ndiscrete\tO\nescape\tO\nresponse\tO\nin\tO\nrats\tO\nexposed\tO\nto\tO\nsublethal\tO\nhypercapnia\tB-Disease\nimmediately\tO\nbefore\tO\nthe\tO\nacquisition\tO\nsession\tO\n;\tO\n(\tO\n2\tO\n)\tO\npartial\tO\n(\tO\nrats\tO\n)\tO\nor\tO\ncomplete\tO\n(\tO\nmice\tO\n)\tO\nprevention\tO\nof\tO\nthe\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\nshort\tO\n-\tO\nterm\tO\namnesia\tB-Disease\nfor\tO\na\tO\npassive\tO\navoidance\tO\ntask\tO\n;\tO\n(\tO\n3\tO\n)\tO\ncomplete\tO\nprotection\tO\nagainst\tO\namnesia\tB-Disease\nfor\tO\na\tO\npassive\tO\navoidance\tO\ntask\tO\nin\tO\nrats\tO\nsubmitted\tO\nto\tO\nelectroconvulsive\tO\nshock\tO\nimmediately\tO\nafter\tO\navoidance\tO\nacquisition\tO\n;\tO\n(\tO\n4\tO\n)\tO\nprevention\tO\nof\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nretention\tO\n-\tO\nor\tO\nretrieval\tO\n-\tO\ndeficit\tO\nfor\tO\na\tO\npassive\tO\navoidance\tO\ntask\tO\ninduced\tO\nin\tO\nrats\tO\nand\tO\nmice\tO\nby\tO\nchloramphenicol\tB-Chemical\nor\tO\ncycloheximide\tB-Chemical\nadministered\tO\nimmediately\tO\nafter\tO\nacquisition\tO\n;\tO\n(\tO\n5\tO\n)\tO\nreversal\tO\n,\tO\nwhen\tO\nadministered\tO\nas\tO\nlate\tO\nas\tO\n1\tO\nh\tO\nbefore\tO\nthe\tO\nretention\tO\ntest\tO\n,\tO\nof\tO\nthe\tO\ndeficit\tO\nin\tO\nretention\tO\nor\tO\nretrieval\tO\nof\tO\na\tO\npassive\tO\navoidance\tO\ntask\tO\ninduced\tO\nby\tO\ncycloheximide\tB-Chemical\ninjected\tO\n2\tO\ndays\tO\npreviously\tO\n;\tO\n(\tO\n6\tO\n)\tO\nprevention\tO\nof\tO\nthe\tO\ndeficit\tO\nin\tO\nthe\tO\nretrieval\tO\nof\tO\nan\tO\nactive\tO\navoidance\tO\ntask\tO\ninduced\tO\nin\tO\nmice\tO\nby\tO\nsubconvulsant\tO\nelectroshock\tO\nor\tO\nhypercapnia\tB-Disease\napplied\tO\nimmediately\tO\nbefore\tO\nretrieval\tO\ntesting\tO\n(\tO\n24\tO\nh\tO\nafter\tO\nacquisition\tO\n)\tO\n.\tO\n\nThese\tO\nimprovements\tO\nor\tO\nnormalizations\tO\nof\tO\nimpaired\tB-Disease\ncognitive\tI-Disease\nfunctions\tI-Disease\nwere\tO\nseen\tO\nat\tO\noral\tO\naniracetam\tB-Chemical\ndoses\tO\nof\tO\n10\tO\n-\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nGenerally\tO\n,\tO\nthe\tO\ndose\tO\n-\tO\nresponse\tO\ncurves\tO\nwere\tO\nbell\tO\n-\tO\nshaped\tO\n.\tO\n\nThe\tO\nmechanisms\tO\nunderlying\tO\nthe\tO\nactivity\tO\nof\tO\naniracetam\tB-Chemical\nand\tO\nits\tO\n'\tO\ntherapeutic\tO\nwindow\tO\n'\tO\nare\tO\nunknown\tO\n.\tO\n\nPiracetam\tB-Chemical\n,\tO\nanother\tO\npyrrolidinone\tB-Chemical\nderivative\tO\nwas\tO\nused\tO\nfor\tO\ncomparison\tO\n.\tO\n\nIt\tO\nwas\tO\nactive\tO\nonly\tO\nin\tO\nsix\tO\nof\tO\nnine\tO\ntests\tO\nand\tO\nhad\tO\nabout\tO\none\tO\n-\tO\ntenth\tO\nthe\tO\npotency\tO\nof\tO\naniracetam\tB-Chemical\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\naniracetam\tB-Chemical\nimproves\tO\ncognitive\tO\nfunctions\tO\nwhich\tO\nare\tO\nimpaired\tO\nby\tO\ndifferent\tO\nprocedure\tO\nand\tO\nin\tO\ndifferent\tO\nphases\tO\nof\tO\nthe\tO\nlearning\tO\nand\tO\nmemory\tO\nprocess\tO\n.\tO\n\nEffect\tO\nof\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\non\tO\ngross\tO\nbehavioural\tO\nchanges\tO\nproduced\tO\nby\tO\ncarbachol\tB-Chemical\nand\tO\neserine\tB-Chemical\nin\tO\ncats\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\ninjected\tO\ninto\tO\nthe\tO\ncerebral\tO\nventricles\tO\nof\tO\ngroup\tO\n-\tO\nhoused\tO\nunanaesthetized\tO\ncats\tO\nupon\tO\nvocalization\tO\n(\tO\nrage\tO\n,\tO\nhissing\tO\nand\tO\nsnarling\tO\n)\tO\n,\tO\nfighting\tO\n(\tO\nattack\tO\nwith\tO\npaws\tO\nand\tO\nclaws\tO\n,\tO\ndefense\tO\nwith\tO\npaws\tO\nand\tO\nclaws\tO\nand\tO\nbiting\tO\n)\tO\n,\tO\nmydriasis\tB-Disease\n,\tO\ntremor\tB-Disease\nand\tO\nclonic\tB-Disease\n-\tI-Disease\ntonic\tI-Disease\nconvulsions\tI-Disease\nproduced\tO\nby\tO\ncarbachol\tB-Chemical\nand\tO\neserine\tB-Chemical\ninjected\tO\nsimilarly\tO\nwas\tO\ninvestigated\tO\n.\tO\n\nCalcium\tB-Chemical\nchloride\tI-Chemical\ndepressed\tO\nor\tO\nalmost\tO\ncompletely\tO\nabolished\tO\nthe\tO\nvocalization\tO\nand\tO\nfighting\tO\ndue\tO\nto\tO\ncarbachol\tB-Chemical\nand\tO\neserine\tB-Chemical\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nmydriasis\tB-Disease\n,\tO\ntremor\tB-Disease\nand\tO\nclonic\tB-Disease\n-\tI-Disease\ntonic\tI-Disease\nconvulsions\tI-Disease\nevoked\tO\nby\tO\ncarbachol\tB-Chemical\nand\tO\neserine\tB-Chemical\nwere\tO\nnot\tO\nsignificantly\tO\nchanged\tO\nby\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\n.\tO\n\nIt\tO\nis\tO\napparent\tO\nthat\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\ncan\tO\n\"\tO\ndissociate\tO\n\"\tO\nvocalization\tO\nand\tO\nfighting\tO\nfrom\tO\nautonomic\tO\nand\tO\nmotor\tO\nphenomena\tO\nsuch\tO\nas\tO\nmydriasis\tB-Disease\n,\tO\ntremor\tB-Disease\nand\tO\nclonic\tB-Disease\n-\tI-Disease\ntonic\tI-Disease\nconvulsions\tI-Disease\ncaused\tO\nby\tO\ncarbachol\tB-Chemical\nand\tO\neserine\tB-Chemical\n.\tO\n\nCalcium\tB-Chemical\nchloride\tI-Chemical\ninhibited\tO\nthe\tO\nvocalization\tO\nand\tO\nfighting\tO\nproduced\tO\nby\tO\ncarbachol\tB-Chemical\nand\tO\neserine\tB-Chemical\nmost\tO\nprobably\tO\nby\tO\na\tO\nnonspecific\tO\nstabilizing\tO\naction\tO\non\tO\ncentral\tO\nmuscarinic\tO\ncholinoceptive\tO\nsites\tO\n.\tO\n\nThese\tO\nresults\tO\nfurther\tO\nsupport\tO\nthe\tO\nview\tO\nthat\tO\ncalcium\tB-Chemical\nions\tO\nin\tO\nexcess\tO\nhave\tO\nan\tO\natropine\tB-Chemical\n-\tO\nlike\tO\naction\tO\nalso\tO\nin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nThiazide\tB-Chemical\ndiuretics\tO\n,\tO\nhypokalemia\tB-Disease\nand\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\n.\tO\n\nThiazide\tB-Chemical\ndiuretics\tO\nare\tO\nwidely\tO\naccepted\tO\nas\tO\nthe\tO\ncornerstone\tO\nof\tO\nantihypertensive\tO\ntreatment\tO\nprograms\tO\n.\tO\n\nHypokalemia\tB-Disease\nis\tO\na\tO\ncommonly\tO\nencountered\tO\nmetabolic\tO\nconsequence\tO\nof\tO\nchronic\tO\nthiazide\tB-Chemical\ntherapy\tO\n.\tO\n\nWe\tO\ntreated\tO\n38\tO\npatients\tO\n(\tO\n22\tO\nlow\tO\nrenin\tO\n,\tO\n16\tO\nnormal\tO\nrenin\tO\n)\tO\nwith\tO\nmoderate\tO\ndiastolic\tB-Disease\nhypertension\tI-Disease\nwith\tO\nhydrochlorothiazide\tB-Chemical\n(\tO\nHCTC\tB-Chemical\n)\tO\nadministered\tO\non\tO\na\tO\ntwice\tO\ndaily\tO\nschedule\tO\n.\tO\n\nInitial\tO\ndose\tO\nwas\tO\n50\tO\nmg\tO\nand\tO\nthe\tO\ndose\tO\nwas\tO\nincreased\tO\nat\tO\nmonthly\tO\nintervals\tO\nto\tO\n100\tO\nmg\tO\n,\tO\n150\tO\nmg\tO\nand\tO\n200\tO\nmg\tO\ndaily\tO\nuntil\tO\nblood\tO\npressure\tO\nnormalized\tO\n.\tO\n\nThe\tO\nserum\tO\nK\tB-Chemical\nduring\tO\nthe\tO\ncontrol\tO\nperiod\tO\nwas\tO\n4\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nmEq\tO\n/\tO\nl\tO\nan\tO\non\tO\n50\tO\n,\tO\n100\tO\n,\tO\n150\tO\nand\tO\n200\tO\nmg\tO\nHCTZ\tB-Chemical\ndaily\tO\n3\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n3\tO\n,\tO\n3\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\n,\tO\n2\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\n,\tO\nand\tO\n2\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n3\tO\nmEq\tO\n/\tO\nl\tO\n,\tO\nrespectively\tO\n.\tO\n\nCorresponding\tO\nfigures\tO\nfor\tO\nwhole\tO\nbody\tO\nK\tB-Chemical\nwere\tO\n4107\tO\n+\tO\n/\tO\n-\tO\n208\tO\n,\tO\n3722\tO\n+\tO\n/\tO\n-\tO\n319\tO\n,\tO\n3628\tO\n+\tO\n/\tO\n-\tO\n257\tO\n,\tO\n3551\tO\n+\tO\n/\tO\n-\tO\n336\tO\n,\tO\nand\tO\n3269\tO\n+\tO\n/\tO\n-\tO\n380\tO\nmEq\tO\n,\tO\nrespectively\tO\n.\tO\n\nIn\tO\n13\tO\npatients\tO\nwe\tO\nobserved\tO\nthe\tO\neffects\tO\nof\tO\nHCTZ\tB-Chemical\ntherapy\tO\n(\tO\n100\tO\nmg\tO\ndaily\tO\n)\tO\non\tO\nthe\tO\noccurrence\tO\nof\tO\nPVC\tO\n'\tO\ns\tO\nduring\tO\nrest\tO\nas\tO\nwell\tO\nas\tO\nduring\tO\nstatic\tO\nand\tO\ndynamic\tO\nexercise\tO\n.\tO\n\nDuring\tO\nrest\tO\nwe\tO\nobserved\tO\n0\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n08\tO\nPVC\tO\nbeats\tO\n/\tO\nmin\tO\n+\tO\n/\tO\n-\tO\nSEM\tO\nand\tO\nduring\tO\nstatic\tO\nand\tO\ndynamic\tO\nexercise\tO\n0\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n06\tO\nand\tO\n0\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n15\tO\n,\tO\nrespectively\tO\n.\tO\n\nCorresponding\tO\nfigures\tO\nduring\tO\nHCTZ\tB-Chemical\ntherapy\tO\n100\tO\nmg\tO\ndaily\tO\nwere\tO\n1\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\n,\tO\n3\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\nand\tO\n5\tO\n.\tO\n7\tO\n4\tO\n/\tO\n-\tO\n0\tO\n.\tO\n8\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\noccurrence\tO\nof\tO\nPVC\tO\n'\tO\ns\tO\ncorrelated\tO\nsignificantly\tO\nwith\tO\nthe\tO\nfall\tO\nin\tO\nserum\tO\nK\tB-Chemical\n+\tO\nobserved\tO\nr\tO\n=\tO\n0\tO\n.\tO\n72\tO\n,\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n.\tO\n\nIn\tO\nconclusion\tO\nwe\tO\nfound\tO\nthat\tO\nthiazide\tB-Chemical\ndiuretics\tO\ncause\tO\nhypokalemia\tB-Disease\nand\tO\ndepletion\tO\nof\tO\nbody\tO\npotassium\tB-Chemical\n.\tO\n\nThe\tO\nmore\tO\nprofound\tO\nhypokalemia\tB-Disease\n,\tO\nthe\tO\ngreater\tO\nthe\tO\npropensity\tO\nfor\tO\nthe\tO\noccurrence\tO\nof\tO\nPVC\tO\n'\tO\ns\tO\n.\tO\n\nCirculating\tO\nlysosomal\tO\nenzymes\tO\nand\tO\nacute\tB-Disease\nhepatic\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nThe\tO\nactivities\tO\nof\tO\nthe\tO\nlysosomal\tO\nenzymes\tO\nacid\tO\nand\tO\nneutral\tO\nprotease\tO\n,\tO\nN\tO\n-\tO\nacetylglucosaminidase\tO\n,\tO\nand\tO\nacid\tO\nphosphatase\tO\nwere\tO\nmeasured\tO\nin\tO\nthe\tO\nserum\tO\nof\tO\npatients\tO\nwith\tO\nfulminant\tB-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\n.\tO\n\nAcid\tO\nprotease\tO\n(\tO\ncathepsin\tO\nD\tO\n)\tO\nactivity\tO\nwas\tO\nincreased\tO\nabout\tO\ntenfold\tO\nin\tO\npatients\tO\nwho\tO\ndied\tO\nand\tO\nnearly\tO\nfourfold\tO\nin\tO\nthose\tO\nwho\tO\nsurvived\tO\nfulminant\tB-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\nafter\tO\nparacetamol\tB-Chemical\noverdose\tB-Disease\n,\tO\nwhereas\tO\nactivities\tO\nwere\tO\nincreased\tO\nequally\tO\nin\tO\npatients\tO\nwith\tO\nfulminant\tB-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\ndue\tO\nto\tO\nviral\tB-Disease\nhepatitis\tI-Disease\nwhether\tO\nor\tO\nnot\tO\nthey\tO\nsurvived\tO\n.\tO\n\nA\tO\ncorrelation\tO\nwas\tO\nfound\tO\nbetween\tO\nserum\tO\nacid\tO\nprotease\tO\nactivity\tO\nand\tO\nprothrombin\tO\ntime\tO\n,\tO\nand\tO\nthe\tO\nincrease\tO\nin\tO\ncathepsin\tO\nD\tO\nactivity\tO\nwas\tO\nsustained\tO\nover\tO\nseveral\tO\ndays\tO\ncompared\tO\nwith\tO\naspartate\tB-Chemical\naminotransferase\tO\n,\tO\nwhich\tO\nshowed\tO\na\tO\nsharp\tO\nearly\tO\npeak\tO\nand\tO\nthen\tO\na\tO\nfall\tO\n.\tO\n\nCirculating\tO\nlysosomal\tO\nproteases\tO\ncan\tO\ndamage\tO\nother\tO\norgans\tO\n,\tO\nand\tO\nmeasurement\tO\nof\tO\ntheir\tO\nactivity\tO\nmay\tO\ntherefore\tO\nbe\tO\nof\tO\nadded\tO\nvalue\tO\nin\tO\nassessing\tO\nprognosis\tO\nin\tO\nthis\tO\ncondition\tO\n.\tO\n\nHepatic\tB-Disease\nveno\tI-Disease\n-\tI-Disease\nocclusive\tI-Disease\ndisease\tI-Disease\ncaused\tO\nby\tO\n6\tB-Chemical\n-\tI-Chemical\nthioguanine\tI-Chemical\n.\tO\n\nClinically\tO\nreversible\tO\nveno\tB-Disease\n-\tI-Disease\nocclusive\tI-Disease\ndisease\tI-Disease\nof\tI-Disease\nthe\tI-Disease\nliver\tI-Disease\ndeveloped\tO\nin\tO\na\tO\n23\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nacute\tB-Disease\nlymphocytic\tI-Disease\nleukemia\tI-Disease\nafter\tO\n10\tO\nmonths\tO\nof\tO\nmaintenance\tO\ntherapy\tO\nwith\tO\n6\tB-Chemical\n-\tI-Chemical\nthioguanine\tI-Chemical\n.\tO\n\nSerial\tO\nliver\tO\nbiopsies\tO\nshowed\tO\nthe\tO\ndevelopment\tO\nand\tO\nresolution\tO\nof\tO\nintense\tO\nsinusoidal\tO\nengorgement\tO\n.\tO\n\nAlthough\tO\nthis\tO\ndisease\tO\nwas\tO\nclinically\tO\nreversible\tO\n,\tO\nsome\tO\nsubintimal\tO\nfibrosis\tB-Disease\nabout\tO\nthe\tO\nterminal\tO\nhepatic\tO\nveins\tO\npersisted\tO\n.\tO\n\nThis\tO\ncase\tO\npresented\tO\na\tO\nunique\tO\nopportunity\tO\nto\tO\nobserve\tO\nthe\tO\nhistologic\tO\nfeatures\tO\nof\tO\nclinically\tO\nreversible\tO\nhepatic\tB-Disease\nveno\tI-Disease\n-\tI-Disease\nocclusive\tI-Disease\ndisease\tI-Disease\nover\tO\ntime\tO\n,\tO\nand\tO\nmay\tO\nbe\tO\nthe\tO\nfirst\tO\ncase\tO\nof\tO\nveno\tO\n-\tO\nocclusive\tO\nrelated\tO\nsolely\tO\nto\tO\n6\tB-Chemical\n-\tI-Chemical\nthioguanine\tI-Chemical\n.\tO\n\nChlorpropamide\tB-Chemical\n-\tO\ninduced\tO\noptic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nA\tO\n65\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nadult\tB-Disease\n-\tI-Disease\nonset\tI-Disease\ndiabetes\tI-Disease\ntreated\tO\nwith\tO\nchlorpropamide\tB-Chemical\n(\tO\nDiabenese\tB-Chemical\n)\tO\nhad\tO\na\tO\ntoxic\tB-Disease\noptic\tI-Disease\nneuropathy\tI-Disease\nthat\tO\nresolved\tO\nwith\tO\ndiscontinuation\tO\nof\tO\nchlorpropamide\tB-Chemical\ntherapy\tO\n.\tO\n\nVisual\tB-Disease\nloss\tI-Disease\noccurs\tO\nin\tO\ndiabetics\tB-Disease\nfor\tO\na\tO\nvariety\tO\nof\tO\nreasons\tO\n,\tO\nand\tO\naccurate\tO\ndiagnosis\tO\nis\tO\nnecessary\tO\nto\tO\ninstitute\tO\nappropriate\tO\ntherapy\tO\n.\tO\n\nThe\tO\npossibility\tO\nof\tO\na\tO\ndrug\tO\n-\tO\ninduced\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nshould\tO\nbe\tO\nconsidered\tO\nin\tO\nthe\tO\ndifferential\tO\ndiagnosis\tO\nof\tO\nvisual\tB-Disease\nloss\tI-Disease\nin\tO\ndiabetics\tB-Disease\n.\tO\n\nPlasma\tO\nand\tO\nurinary\tO\nlipids\tO\nand\tO\nlipoproteins\tO\nduring\tO\nthe\tO\ndevelopment\tO\nof\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\ninduced\tO\nin\tO\nthe\tO\nrat\tO\nby\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\nascertain\tO\nwhether\tO\nthe\tO\nalterations\tO\nof\tO\nplasma\tO\nlipoproteins\tO\nfound\tO\nin\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\ninduced\tO\nby\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nwere\tO\ndue\tO\nto\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\nper\tO\nse\tO\n,\tO\nor\tO\n,\tO\nat\tO\nleast\tO\nin\tO\npart\tO\n,\tO\nto\tO\nthe\tO\naminonucleoside\tB-Chemical\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthe\tO\nchanges\tO\nin\tO\nplasma\tO\nand\tO\nurinary\tO\nlipoproteins\tO\nduring\tO\nthe\tO\nadministration\tO\nof\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\nfor\tO\n7\tO\ndays\tO\n)\tO\nand\tO\nthe\tO\nsubsequent\tO\ndevelopment\tO\nof\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nSince\tO\nmassive\tO\nalbuminuria\tB-Disease\noccurred\tO\nafter\tO\n6\tO\ndays\tO\nof\tO\ntreatment\tO\n,\tO\nthe\tO\ntime\tO\n-\tO\ncourse\tO\nstudy\tO\nwas\tO\ndivided\tO\ninto\tO\ntwo\tO\nstages\tO\n:\tO\npre\tO\n-\tO\nnephrotic\tB-Disease\nstage\tO\n(\tO\nday\tO\n1\tO\n-\tO\n5\tO\n)\tO\nand\tO\nnephrotic\tB-Disease\nstage\tO\n(\tO\nday\tO\n6\tO\n-\tO\n11\tO\n)\tO\n.\tO\n\nIn\tO\npre\tO\n-\tO\nnephrotic\tB-Disease\nstage\tO\nthe\tO\nplasma\tO\nlevel\tO\nof\tO\nfatty\tB-Chemical\nacids\tI-Chemical\n,\tO\ntriacylglycerol\tB-Chemical\nand\tO\nVLDL\tO\ndecreased\tO\nwhile\tO\nthat\tO\nof\tO\nphospholipid\tO\n,\tO\ncholesteryl\tB-Chemical\nesters\tI-Chemical\nand\tO\nHDL\tO\nremained\tO\nconstant\tO\n.\tO\n\nPlasma\tO\napolipoprotein\tO\nA\tO\n-\tO\nI\tO\ntended\tO\nto\tO\nincrease\tO\n(\tO\n40\tO\n%\tO\nincrease\tO\nat\tO\nday\tO\n5\tO\n)\tO\n.\tO\n\nAt\tO\nthe\tO\nbeginning\tO\nof\tO\nnephrotic\tB-Disease\nstage\tO\n(\tO\nday\tO\n6\tO\n)\tO\nthe\tO\nconcentration\tO\nof\tO\nplasma\tO\nalbumin\tO\ndropped\tO\nto\tO\na\tO\nvery\tO\nlow\tO\nlevel\tO\n,\tO\nwhile\tO\nthat\tO\nof\tO\napolipoprotein\tO\nA\tO\n-\tO\nI\tO\nincreased\tO\nabruptly\tO\n(\tO\n4\tO\n-\tO\nfold\tO\nincrease\tO\n)\tO\nand\tO\ncontinued\tO\nto\tO\nrise\tO\n,\tO\nalthough\tO\nless\tO\nsteeply\tO\n,\tO\nin\tO\nthe\tO\nfollowing\tO\ndays\tO\n.\tO\n\nThe\tO\nplasma\tO\nconcentration\tO\nof\tO\nHDL\tO\nfollowed\tO\nthe\tO\nsame\tO\npattern\tO\n.\tO\n\nPlasma\tO\nVLDL\tO\nand\tO\nLDL\tO\nincreased\tO\nat\tO\na\tO\nlater\tO\nstage\tO\n(\tO\nday\tO\n9\tO\n)\tO\n.\tO\n\nPlasma\tO\napolipoprotein\tO\nA\tO\n-\tO\nI\tO\nwas\tO\nfound\tO\nnot\tO\nonly\tO\nin\tO\nHDL\tO\n(\tO\n1\tO\n.\tO\n063\tO\n-\tO\n1\tO\n.\tO\n210\tO\ng\tO\n/\tO\nml\tO\n)\tO\nbut\tO\nalso\tO\nin\tO\nthe\tO\nLDL\tO\ndensity\tO\nclass\tO\n(\tO\n1\tO\n.\tO\n025\tO\n-\tO\n1\tO\n.\tO\n050\tO\ng\tO\n/\tO\nml\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\npre\tO\n-\tO\nnephrotic\tB-Disease\nstage\tO\nlipoproteinuria\tO\nwas\tO\nnegligible\tO\n,\tO\nwhile\tO\nin\tO\nthe\tO\nearly\tO\nnephrotic\tB-Disease\nstage\tO\nthe\tO\nurinary\tO\nloss\tO\nof\tO\nplasma\tO\nlipoproteins\tO\nconsisted\tO\nmainly\tO\nof\tO\nHDL\tO\n.\tO\n\nThese\tO\nobservations\tO\nindicate\tO\nthat\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nalters\tO\nplasma\tO\nlipoproteins\tO\nby\tO\nlowering\tO\nVLDL\tO\nand\tO\nincreasing\tO\nHDL\tO\n.\tO\n\nIt\tO\nis\tO\nlikely\tO\nthat\tO\nthe\tO\nearly\tO\nand\tO\nstriking\tO\nincrease\tO\nof\tO\nplasma\tO\nHDL\tO\nfound\tO\nin\tO\nnephrotic\tB-Disease\nrats\tO\nis\tO\nrelated\tO\nto\tO\na\tO\ndirect\tO\neffect\tO\nof\tO\nthe\tO\ndrug\tO\non\tO\nHDL\tO\nmetabolism\tO\n.\tO\n\nFatal\tO\naplastic\tB-Disease\nanemia\tI-Disease\nfollowing\tO\ntopical\tO\nadministration\tO\nof\tO\nophthalmic\tO\nchloramphenicol\tB-Chemical\n.\tO\n\nA\tO\n73\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\ndied\tO\nof\tO\naplastic\tB-Disease\nanemia\tI-Disease\nless\tO\nthan\tO\ntwo\tO\nmonths\tO\nafter\tO\nundergoing\tO\ncataract\tB-Disease\nextraction\tO\nand\tO\nbeginning\tO\ntopical\tO\ntherapy\tO\nwith\tO\nchloramphenicol\tB-Chemical\n.\tO\n\nThe\tO\nfirst\tO\nsigns\tO\nof\tO\npancytopenia\tB-Disease\nbegan\tO\nwithin\tO\none\tO\nmonth\tO\nof\tO\nthe\tO\nsurgery\tO\n.\tO\n\nThe\tO\npattern\tO\nof\tO\nthe\tO\naplastic\tB-Disease\nanemia\tI-Disease\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nidiosyncratic\tO\nresponse\tO\nto\tO\nchloramphenicol\tB-Chemical\n.\tO\n\nThis\tO\nwas\tO\nthe\tO\nsecond\tO\nreport\tO\nof\tO\nfatal\tO\naplastic\tB-Disease\nanemia\tI-Disease\nafter\tO\ntopical\tO\ntreatment\tO\nwith\tO\nchloramphenicol\tB-Chemical\nfor\tO\nocular\tO\nconditions\tO\n,\tO\nalthough\tO\ntwo\tO\ncases\tO\nof\tO\nreversible\tO\nbone\tB-Disease\nmarrow\tI-Disease\nhypoplasia\tI-Disease\nhave\tO\nalso\tO\nbeen\tO\nreported\tO\n.\tO\n\nAny\tO\nother\tO\nsuspected\tO\ncases\tO\nof\tO\nocular\tB-Disease\ntoxicity\tI-Disease\nassociated\tO\nwith\tO\ntopically\tO\napplied\tO\nchloramphenicol\tB-Chemical\nshould\tO\nbe\tO\nreported\tO\nto\tO\nthe\tO\nNational\tO\nRegistry\tO\nof\tO\nDrug\tO\n-\tO\nInduced\tO\nOcular\tO\nSide\tO\nEffects\tO\n,\tO\nOregon\tO\nHealth\tO\nSciences\tO\nUniversity\tO\n,\tO\nPortland\tO\n,\tO\nOR\tO\n97201\tO\n.\tO\n\nMidazolam\tB-Chemical\ncompared\tO\nwith\tO\nthiopentone\tB-Chemical\nas\tO\nan\tO\ninduction\tO\nagent\tO\n.\tO\n\nIn\tO\npatients\tO\npremedicated\tO\nwith\tO\nscopolamine\tB-Chemical\n+\tO\nmorphine\tB-Chemical\n(\tO\n+\tO\n5\tO\nmg\tO\nnitrazepam\tB-Chemical\nthe\tO\nevening\tO\nbefore\tO\nsurgery\tO\n)\tO\n,\tO\nthe\tO\nsleep\tO\n-\tO\ninducing\tO\neffect\tO\nof\tO\nmidazolam\tB-Chemical\n0\tO\n.\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\nwas\tO\nclearly\tO\nslower\tO\nin\tO\nonset\tO\nthan\tO\nthat\tO\nof\tO\nthiopentone\tB-Chemical\n4\tO\n.\tO\n67\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\nSomewhat\tO\nfewer\tO\ncardiovascular\tO\nand\tO\nlocal\tO\nsequelae\tO\nwere\tO\nfound\tO\nin\tO\nthe\tO\nmidazolam\tB-Chemical\ngroup\tO\n,\tO\nbut\tO\n,\tO\nalthough\tO\napnoea\tB-Disease\noccurred\tO\nless\tO\noften\tO\nin\tO\nthe\tO\nmidazolam\tB-Chemical\ngroup\tO\nit\tO\nlasted\tO\nlonger\tO\n.\tO\n\nOn\tO\nthe\tO\nwhole\tO\n,\tO\nthe\tO\ndifferences\tO\nbetween\tO\nmidazolam\tB-Chemical\nand\tO\nthiopentone\tB-Chemical\nhad\tO\nno\tO\napparent\tO\nclinical\tO\nconsequences\tO\n.\tO\n\nMidazolam\tB-Chemical\nis\tO\na\tO\nnew\tO\nalternative\tO\nagent\tO\nfor\tO\ninduction\tO\nin\tO\ncombination\tO\nanaesthesia\tO\n.\tO\n\nExtrapyramidal\tO\nside\tO\neffects\tO\nand\tO\noral\tO\nhaloperidol\tB-Chemical\n:\tO\nan\tO\nanalysis\tO\nof\tO\nexplanatory\tO\npatient\tO\nand\tO\ntreatment\tO\ncharacteristics\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nextrapyramidal\tO\nside\tO\neffects\tO\n(\tO\nEPS\tO\n)\tO\nwas\tO\nevaluated\tO\nin\tO\n98\tO\npatients\tO\ntreated\tO\nwith\tO\nhaloperidol\tB-Chemical\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nparkinsonism\tB-Disease\nwas\tO\nhigher\tO\nat\tO\nhigher\tO\ndoses\tO\nof\tO\nhaloperidol\tB-Chemical\nand\tO\nin\tO\nyounger\tO\npatients\tO\n.\tO\n\nProphylactic\tO\nantiparkinsonian\tO\nmedication\tO\nwas\tO\neffective\tO\nin\tO\nyounger\tO\nbut\tO\nnot\tO\nin\tO\nolder\tO\npatients\tO\n.\tO\n\nHowever\tO\n,\tO\nthese\tO\nmedications\tO\nwere\tO\nmore\tO\neffective\tO\nin\tO\nboth\tO\nyoung\tO\nand\tO\nold\tO\npatients\tO\nwhen\tO\ngiven\tO\nafter\tO\nparkinsonism\tB-Disease\ndeveloped\tO\n.\tO\n\nAkathisia\tB-Disease\nwas\tO\ncontrolled\tO\nby\tO\nthe\tO\nbenzodiazepine\tB-Chemical\nlorazepam\tB-Chemical\nin\tO\n14\tO\nout\tO\nof\tO\n16\tO\npatients\tO\n,\tO\nwhile\tO\nprophylactic\tO\nantiparkinsonians\tO\nwere\tO\nineffective\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\npoints\tO\nto\tO\npatient\tO\ncharacteristics\tO\nthat\tO\nmay\tO\nbe\tO\nof\tO\nsignificance\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nEPS\tO\ndue\tO\nto\tO\nhaloperidol\tB-Chemical\n.\tO\n\nDeaths\tO\nfrom\tO\nlocal\tO\nanesthetic\tO\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nMedian\tO\nconvulsant\tO\n(\tO\nCD50\tO\n)\tO\nand\tO\nmedian\tO\nlethal\tO\n(\tO\nLD50\tO\n)\tO\ndoses\tO\nof\tO\nthree\tO\nrepresentative\tO\nlocal\tO\nanesthetics\tO\nwere\tO\ndetermined\tO\nin\tO\nadult\tO\nmice\tO\nto\tO\nevaluate\tO\nthe\tO\nthreat\tO\nto\tO\nlife\tO\nof\tO\nlocal\tO\nanesthetic\tO\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nThe\tO\nCD50\tO\nand\tO\nLD50\tO\n,\tO\nrespectively\tO\n,\tO\nwere\tO\n57\tO\n.\tO\n7\tO\nand\tO\n58\tO\n.\tO\n7\tO\nmg\tO\n/\tO\nkg\tO\nfor\tO\nbupivacaine\tB-Chemical\n,\tO\n111\tO\n.\tO\n0\tO\nand\tO\n133\tO\n.\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\nfor\tO\nlidocaine\tB-Chemical\n,\tO\nand\tO\n243\tO\n.\tO\n4\tO\nand\tO\n266\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nfor\tO\nchloroprocaine\tB-Chemical\n.\tO\n\nWhen\tO\ngiven\tO\nintraperitoneally\tO\n,\tO\nbupivacaine\tB-Chemical\nthus\tO\nwas\tO\nonly\tO\nabout\tO\ntwice\tO\nas\tO\ntoxic\tO\nas\tO\nlidocaine\tB-Chemical\nand\tO\nfour\tO\ntimes\tO\nas\tO\ntoxic\tO\nas\tO\nchloroprocaine\tB-Chemical\n.\tO\n\nConvulsions\tB-Disease\nalways\tO\npreceded\tO\ndeath\tO\n,\tO\nexcept\tO\nafter\tO\nprecipitous\tO\ncardiopulmonary\tB-Disease\narrest\tI-Disease\nfrom\tO\nextreme\tO\ndoses\tO\n.\tO\n\nA\tO\nCD50\tO\ndose\tO\nof\tO\nlocal\tO\nanesthetic\tO\n(\tO\ncausing\tO\nconvulsions\tB-Disease\nin\tO\n50\tO\n%\tO\nof\tO\nmice\tO\n)\tO\nwas\tO\nfatal\tO\nin\tO\n90\tO\n%\tO\nof\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n,\tO\nin\tO\n57\tO\n%\tO\nof\tO\nthe\tO\nchloroprocaine\tB-Chemical\ngroup\tO\n,\tO\nand\tO\nin\tO\n6\tO\n%\tO\nof\tO\nthe\tO\nlidocaine\tB-Chemical\ngroup\tO\n.\tO\n\nThe\tO\nnarrow\tO\ngap\tO\nbetween\tO\nconvulsant\tO\nand\tO\nlethal\tO\ndoses\tO\nof\tO\nlocal\tO\nanesthetics\tO\nindicates\tO\nthat\tO\nuntreated\tO\nconvulsions\tB-Disease\npresent\tO\nmuch\tO\nmore\tO\nof\tO\na\tO\nthreat\tO\nto\tO\nlife\tO\nthan\tO\nheretofore\tO\nappreciated\tO\n.\tO\n\nREM\tB-Disease\nsleep\tI-Disease\ndeprivation\tI-Disease\nchanges\tO\nbehavioral\tO\nresponse\tO\nto\tO\ncatecholaminergic\tO\nand\tO\nserotonergic\tO\nreceptor\tO\nactivation\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nREM\tB-Disease\nsleep\tI-Disease\ndeprivation\tI-Disease\n(\tO\nREMD\tB-Disease\n)\tO\non\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\naggressiveness\tB-Disease\nand\tO\nquipazine\tB-Chemical\n-\tO\ninduced\tO\nhead\tB-Disease\ntwitches\tI-Disease\nin\tO\nrats\tO\nwere\tO\ndetermined\tO\n.\tO\n\nForty\tO\n-\tO\neight\tO\nhr\tO\nof\tO\nREMD\tB-Disease\nincreased\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\naggressiveness\tB-Disease\n,\tO\nand\tO\nreduced\tO\n(\tO\nimmediately\tO\nafter\tO\ncompleting\tO\nof\tO\nREMD\tB-Disease\n)\tO\nor\tO\nincreased\tO\n(\tO\n96\tO\nhr\tO\nafter\tO\ncompleting\tO\nof\tO\nREMD\tB-Disease\n)\tO\nquipazine\tB-Chemical\n-\tO\ninduced\tO\nhead\tB-Disease\ntwitches\tI-Disease\n.\tO\n\nResults\tO\nare\tO\ndiscussed\tO\nin\tO\nterms\tO\nof\tO\nsimilarity\tO\nto\tO\npharmacological\tO\neffects\tO\nof\tO\nother\tO\nantidepressive\tO\ntreatments\tO\n.\tO\n\nFatal\tO\naplastic\tB-Disease\nanemia\tI-Disease\ndue\tO\nto\tO\nindomethacin\tB-Chemical\n-\tO\n-\tO\nlymphocyte\tO\ntransformation\tO\ntests\tO\nin\tO\nvitro\tO\n.\tO\n\nAlthough\tO\nindomethacin\tB-Chemical\nhas\tO\nbeen\tO\nimplicated\tO\nas\tO\na\tO\npossible\tO\ncause\tO\nof\tO\naplastic\tB-Disease\nanemia\tI-Disease\non\tO\nthe\tO\nbasis\tO\nof\tO\na\tO\nfew\tO\nclinical\tO\nobservations\tO\n,\tO\nits\tO\nrole\tO\nhas\tO\nnot\tO\nbeen\tO\ndefinitely\tO\nestablished\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nfatal\tO\naplastic\tB-Disease\nanemia\tI-Disease\nis\tO\ndescribed\tO\nin\tO\nwhich\tO\nno\tO\ndrugs\tO\nother\tO\nthan\tO\nallopurinol\tB-Chemical\nand\tO\nindomethacin\tB-Chemical\nwere\tO\ngiven\tO\n.\tO\n\nIndomethacin\tB-Chemical\nwas\tO\nfirst\tO\ngiven\tO\nfour\tO\nweeks\tO\nprior\tO\nto\tO\nthe\tO\nonset\tO\nof\tO\nsymptoms\tO\n.\tO\n\nA\tO\npositive\tO\nlymphocyte\tO\ntransformation\tO\ntest\tO\nwith\tO\nindomethacin\tB-Chemical\nin\tO\nvitro\tO\nfurther\tO\nsubstantiates\tO\nthe\tO\npotential\tO\nrole\tO\nof\tO\nthis\tO\ndrug\tO\nin\tO\ncausing\tO\naplastic\tB-Disease\nanemia\tI-Disease\nin\tO\na\tO\nsusceptible\tO\npatient\tO\n.\tO\n\nFortunately\tO\n,\tO\nthis\tO\nseems\tO\nto\tO\nbe\tO\na\tO\nvery\tO\nrare\tO\ncomplication\tO\n.\tO\n\nDose\tO\n-\tO\neffect\tO\nand\tO\nstructure\tO\n-\tO\nfunction\tO\nrelationships\tO\nin\tO\ndoxorubicin\tB-Chemical\ncardiomyopathy\tB-Disease\n.\tO\n\nThe\tO\ncardiomyopathy\tB-Disease\n(\tO\nCM\tB-Disease\n)\tO\nproduced\tO\nby\tO\nthe\tO\nanticancer\tO\ndrug\tO\ndoxorubicin\tB-Chemical\n(\tO\nDXR\tB-Chemical\n)\tO\n(\tO\nAdriamycin\tB-Chemical\n)\tO\nprovides\tO\na\tO\nunique\tO\nopportunity\tO\nto\tO\nanalyze\tO\ndose\tO\n-\tO\neffect\tO\nand\tO\nstructure\tO\n-\tO\nfunction\tO\nrelationships\tO\nduring\tO\ndevelopment\tO\nof\tO\nmyocardial\tB-Disease\ndisease\tI-Disease\n.\tO\n\nWe\tO\nmeasured\tO\nthe\tO\ndegree\tO\nof\tO\nmorphologic\tO\ndamage\tO\nby\tO\nultrastructural\tO\nexamination\tO\nof\tO\nendomyocardial\tO\nbiopsy\tO\nand\tO\nthe\tO\ndegree\tO\nof\tO\nperformance\tO\nabnormally\tO\nby\tO\nright\tO\nheart\tO\ncatheterization\tO\nin\tO\npatients\tO\nreceiving\tO\nDXR\tB-Chemical\n.\tO\n\nMorphologic\tO\ndamage\tO\nwas\tO\nvariable\tO\nbut\tO\nwas\tO\nproportional\tO\nto\tO\nthe\tO\ntotal\tO\ncumulative\tO\nDXR\tB-Chemical\ndose\tO\nbetween\tO\n100\tO\nand\tO\n600\tO\nmg\tO\n/\tO\nm2\tO\n.\tO\n\nPerformance\tO\nabnormalities\tO\ncorrelated\tO\nweakly\tO\nwith\tO\ndose\tO\n,\tO\nexhibited\tO\na\tO\ncurvilinear\tO\nrelationship\tO\n,\tO\nand\tO\nhad\tO\na\tO\n\"\tO\nthreshold\tO\n\"\tO\nfor\tO\nexpression\tO\n.\tO\n\nCatheterization\tO\nabnormalities\tO\ncorrelated\tO\nwell\tO\nwith\tO\nmorphologic\tO\ndamage\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n57\tO\nto\tO\n0\tO\n.\tO\n78\tO\n)\tO\nin\tO\na\tO\nsubgroup\tO\nof\tO\npatients\tO\nin\tO\nwhom\tO\nexercise\tO\nhemodynamics\tO\nwere\tO\nmeasured\tO\n,\tO\nand\tO\nthis\tO\nrelationship\tO\nalso\tO\nexhibited\tO\na\tO\ncurvilinear\tO\n,\tO\nthreshold\tO\nconfiguration\tO\n.\tO\n\nIn\tO\nDXR\tB-Chemical\n-\tO\nCM\tB-Disease\nmyocardial\tB-Disease\ndamage\tI-Disease\nis\tO\nproportional\tO\nto\tO\nthe\tO\ndegree\tO\nof\tO\ncytotoxic\tO\ninsult\tO\n(\tO\nDXR\tB-Chemical\ndose\tO\n)\tO\nwhile\tO\nmyocardial\tO\nfunction\tO\nis\tO\npreserved\tO\nuntil\tO\na\tO\ncritical\tO\ndose\tO\nor\tO\ndegree\tO\nof\tO\ndamage\tO\nis\tO\nreached\tO\n,\tO\nafter\tO\nwhich\tO\nmyocardial\tO\nperformance\tO\ndeteriorates\tO\nrapidly\tO\n.\tO\n\nMassive\tO\ncerebral\tB-Disease\nedema\tI-Disease\nassociated\tO\nwith\tO\nfulminant\tO\nhepatic\tB-Disease\nfailure\tI-Disease\nin\tO\nacetaminophen\tB-Chemical\noverdose\tB-Disease\n:\tO\npossible\tO\nrole\tO\nof\tO\ncranial\tO\ndecompression\tO\n.\tO\n\nCerebral\tB-Disease\nedema\tI-Disease\nmay\tO\ncomplicate\tO\nthe\tO\ncourse\tO\nof\tO\nfulminant\tB-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\n.\tO\n\nResponse\tO\nto\tO\nconventional\tO\ntherapy\tO\nhas\tO\nbeen\tO\ndisappointing\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\npatient\tO\nwith\tO\nfatal\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nfulminant\tB-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\n,\tO\nwith\tO\nsigns\tO\nand\tO\nsymptoms\tO\nof\tO\ncerebral\tB-Disease\nedema\tI-Disease\n,\tO\nunresponsive\tO\nto\tO\nconventional\tO\nmedical\tO\ntherapy\tO\n.\tO\n\nCranial\tO\ndecompression\tO\nwas\tO\ncarried\tO\nout\tO\n.\tO\n\nA\tO\njustification\tO\nof\tO\nthe\tO\nneed\tO\nfor\tO\nfurther\tO\nevaluation\tO\nof\tO\ncranial\tO\ndecompression\tO\nin\tO\nsuch\tO\npatients\tO\nis\tO\npresented\tO\n.\tO\n\nSubjective\tO\nassessment\tO\nof\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\nof\tO\npatients\tO\non\tO\nlong\tO\n-\tO\nterm\tO\nadministration\tO\nof\tO\ndigoxin\tB-Chemical\n.\tO\n\nVarious\tO\ndata\tO\nsuggest\tO\nthat\tO\nmale\tO\npatients\tO\nwho\tO\nhave\tO\nreceived\tO\ndigoxin\tB-Chemical\non\tO\na\tO\nlongterm\tO\nbasis\tO\nhave\tO\nincreased\tO\nlevels\tO\nof\tO\nserum\tO\nestrogen\tB-Chemical\nand\tO\ndecreased\tO\nlevels\tO\nof\tO\nplasma\tO\ntestosterone\tB-Chemical\nand\tO\nluteinizing\tO\nhormone\tO\n(\tO\nLH\tO\n)\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tO\nlinks\tO\nbetween\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nadministration\tO\nof\tO\ndigoxin\tB-Chemical\ntherapy\tO\nand\tO\nsexual\tO\nbehavior\tO\n,\tO\nand\tO\nthe\tO\neffect\tO\nof\tO\ndigoxin\tB-Chemical\non\tO\nplasma\tO\nlevels\tO\nof\tO\nestradiol\tB-Chemical\n,\tO\ntestosterone\tB-Chemical\n,\tO\nand\tO\nLH\tO\n.\tO\n\nThe\tO\npatients\tO\nof\tO\nthe\tO\nstudy\tO\nand\tO\ncontrol\tO\ngroup\tO\n(\tO\nwithout\tO\ndigoxin\tB-Chemical\n)\tO\nwere\tO\nof\tO\nsimilar\tO\ncardiac\tO\nfunctional\tO\ncapacity\tO\nand\tO\nage\tO\n(\tO\n25\tO\n-\tO\n40\tO\nyears\tO\n)\tO\nand\tO\nwere\tO\nrandomly\tO\nselected\tO\nfrom\tO\nthe\tO\nrheumatic\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\npatients\tO\n.\tO\n\nA\tO\nsubjective\tO\nassessment\tO\nof\tO\nsexual\tO\nbehavior\tO\nin\tO\nthe\tO\nstudy\tO\nand\tO\ncontrol\tO\ngroups\tO\nwas\tO\ncarried\tO\nout\tO\n,\tO\nusing\tO\nparameters\tO\nsuch\tO\nas\tO\nsexual\tO\ndesire\tO\n,\tO\nsexual\tO\nexcitement\tO\n,\tO\nand\tO\nfrequency\tO\nof\tO\nsexual\tO\nrelations\tO\n.\tO\n\nPersonal\tO\ninterviews\tO\nand\tO\na\tO\nquestionnaire\tO\nwere\tO\nalso\tO\nused\tO\nfor\tO\nthe\tO\nevaluation\tO\nof\tO\nsexual\tO\nbehavior\tO\n.\tO\n\nThe\tO\nfindings\tO\nsupport\tO\nthe\tO\nreports\tO\nconcerning\tO\ndigoxin\tB-Chemical\neffect\tO\non\tO\nplasma\tO\nestradiol\tB-Chemical\n,\tO\ntestosterone\tB-Chemical\n,\tO\nand\tO\nLH\tO\n.\tO\n\nThe\tO\ndifferences\tO\nin\tO\nthe\tO\nmeans\tO\nwere\tO\nsignificant\tO\n.\tO\n\nTests\tO\nused\tO\nto\tO\nevaluate\tO\nthe\tO\nchanges\tO\nin\tO\nsexual\tO\nbehavior\tO\nshowed\tO\na\tO\nsignificant\tO\ndecrease\tB-Disease\nin\tI-Disease\nsexual\tI-Disease\ndesire\tI-Disease\n,\tO\nsexual\tO\nexcitement\tO\nphase\tO\n(\tO\nerection\tO\n)\tO\n,\tO\nand\tO\nfrequency\tO\nof\tO\nsexual\tO\nrelations\tO\nin\tO\nthe\tO\nstudy\tO\ngroup\tO\n.\tO\n\nEndometrial\tB-Disease\ncarcinoma\tI-Disease\nafter\tO\nHodgkin\tB-Disease\ndisease\tI-Disease\nin\tO\nchildhood\tO\n.\tO\n\nA\tO\n34\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\ndeveloped\tO\nmetastic\tO\nendometrial\tB-Disease\ncarcinoma\tI-Disease\nafter\tO\nHodgkin\tB-Disease\ndisease\tI-Disease\nin\tO\nchildhood\tO\n.\tO\n\nShe\tO\nhad\tO\novarian\tB-Disease\nfailure\tI-Disease\nafter\tO\nabdominal\tO\nirradiation\tO\nand\tO\nchemotherapy\tO\nfor\tO\nHodgkin\tB-Disease\ndisease\tI-Disease\n,\tO\nand\tO\nreceived\tO\nexogenous\tO\nestrogens\tB-Chemical\n,\tO\na\tO\ntreatment\tO\nimplicated\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nendometrial\tB-Disease\ncancer\tI-Disease\nin\tO\nmenopausal\tO\nwomen\tO\n.\tO\n\nYoung\tO\nwomen\tO\non\tO\nreplacement\tO\nestrogens\tB-Chemical\nfor\tO\novarian\tB-Disease\nfailure\tI-Disease\nafter\tO\ncancer\tB-Disease\ntherapy\tO\nmay\tO\nalso\tO\nhave\tO\nincreased\tO\nrisk\tO\nof\tO\nendometrial\tB-Disease\ncarcinoma\tI-Disease\nand\tO\nshould\tO\nbe\tO\nexamined\tO\nperiodically\tO\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nlithium\tB-Chemical\ntreatment\tO\nand\tO\nthe\tO\nkidney\tO\n.\tO\n\nInterim\tO\nreport\tO\non\tO\nfifty\tO\npatients\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\nreport\tO\non\tO\nthe\tO\nfirst\tO\npart\tO\nof\tO\nour\tO\nstudy\tO\nof\tO\nthe\tO\neffects\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nlithium\tB-Chemical\ntreatment\tO\non\tO\nthe\tO\nkidney\tO\n.\tO\n\nCreatinine\tB-Chemical\nclearance\tO\n,\tO\nmaximum\tO\nurinary\tO\nosmolality\tO\nand\tO\n24\tO\nhour\tO\nurine\tO\nvolume\tO\nhave\tO\nbeen\tO\ntested\tO\nin\tO\n50\tO\naffectively\tO\nill\tO\npatients\tO\nwho\tO\nhave\tO\nbeen\tO\non\tO\nlong\tO\n-\tO\nterm\tO\nlithium\tB-Chemical\nfor\tO\nmore\tO\nthan\tO\none\tO\nyear\tO\n.\tO\n\nThese\tO\nfindings\tO\nhave\tO\nbeen\tO\ncompared\tO\nwith\tO\nnorms\tO\nand\tO\nwith\tO\nvalues\tO\nof\tO\nthe\tO\nsame\tO\ntests\tO\nfrom\tO\nscreening\tO\nprior\tO\nto\tO\nlithium\tB-Chemical\n,\tO\navailable\tO\nfor\tO\nmost\tO\nof\tO\nour\tO\npatients\tO\n.\tO\n\nNo\tO\nevidence\tO\nwas\tO\nfound\tO\nfor\tO\nany\tO\nreduction\tO\nof\tO\nglomerular\tO\nfiltration\tO\nduring\tO\nlithium\tB-Chemical\ntreatment\tO\n.\tO\n\nLow\tO\nclearance\tO\nvalues\tO\nfound\tO\nin\tO\nseveral\tO\npatients\tO\ncould\tO\nbe\tO\naccounted\tO\nfor\tO\nby\tO\ntheir\tO\nage\tO\nand\tO\ntheir\tO\npre\tO\n-\tO\nlithium\tB-Chemical\nvalues\tO\n.\tO\n\nUrinary\tO\nconcentration\tO\ndefect\tO\nappeared\tO\nfrequent\tO\nbut\tO\nthe\tO\nextent\tO\nof\tO\nthe\tO\nimpairment\tO\nis\tO\ndifficult\tO\nto\tO\nassess\tO\nbecause\tO\nof\tO\nthe\tO\nuncertainty\tO\nabout\tO\nthe\tO\nnorms\tO\napplicable\tO\nto\tO\nthis\tO\ngroup\tO\nof\tO\npatients\tO\n.\tO\n\nThe\tO\nconcentration\tO\ndefect\tO\nappeared\tO\nreversible\tO\n,\tO\nat\tO\nleast\tO\nin\tO\npart\tO\n.\tO\n\nPolyuria\tB-Disease\nabove\tO\n3\tO\nlitres\tO\n/\tO\n24\tO\nhours\tO\nwas\tO\nfound\tO\nin\tO\n10\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nAn\tO\nattempt\tO\nis\tO\nmade\tO\nto\tO\ndraw\tO\npractical\tO\nconclusions\tO\nfrom\tO\nthe\tO\npreliminary\tO\nfindings\tO\n.\tO\n\nNephrotoxicity\tB-Disease\nof\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\nand\tO\nFK506\tB-Chemical\n:\tO\ninhibition\tO\nof\tO\ncalcineurin\tO\nphosphatase\tO\n.\tO\n\nCyclosporin\tB-Chemical\nA\tI-Chemical\n(\tO\nCsA\tB-Chemical\n;\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\nFujimycine\tB-Chemical\n(\tO\nFK506\tB-Chemical\n;\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nbut\tO\nnot\tO\nthe\tO\nrelated\tO\nmacrolide\tB-Chemical\nimmunosuppressant\tO\nrapamycin\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\ncaused\tO\na\tO\nreduction\tO\nof\tO\nglomerular\tO\nfiltration\tO\nrate\tO\n,\tO\ndegenerative\tO\nchanges\tO\nof\tO\nproximal\tO\ntubular\tO\nepithelium\tO\n,\tO\nand\tO\nhypertrophy\tB-Disease\nof\tO\nthe\tO\njuxtaglomerular\tO\napparatus\tO\nin\tO\nmale\tO\nWistar\tO\nrats\tO\nwhen\tO\ngiven\tO\nfor\tO\n10\tO\ndays\tO\n.\tO\n\nThe\tO\nmolecular\tO\nmechanisms\tO\nof\tO\nCsA\tB-Chemical\nand\tO\nFK506\tB-Chemical\ntoxicity\tB-Disease\nwere\tO\ninvestigated\tO\n.\tO\n\nCyclophilin\tO\nA\tO\nand\tO\nFK506\tB-Chemical\n-\tO\nbinding\tO\nprotein\tO\n,\tO\nthe\tO\nmain\tO\nintracytoplasmic\tO\nreceptors\tO\nfor\tO\nCsA\tB-Chemical\nand\tO\nFK506\tB-Chemical\n,\tO\nrespectively\tO\n,\tO\nwere\tO\neach\tO\ndetected\tO\nin\tO\nrenal\tO\ntissue\tO\nextract\tO\n.\tO\n\nIn\tO\nthe\tO\nkidney\tO\n,\tO\nhigh\tO\nlevels\tO\nof\tO\nimmunoreactive\tO\nand\tO\nenzymatically\tO\nactive\tO\ncalcineurin\tO\nwere\tO\nfound\tO\nwhich\tO\nwere\tO\ninhibited\tO\nby\tO\nthe\tO\nimmunosuppressants\tO\nCsA\tB-Chemical\nand\tO\nFK506\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nby\tO\nrapamycin\tB-Chemical\n.\tO\n\nFinally\tO\n,\tO\nspecific\tO\nimmunophilin\tO\n-\tO\ndrug\tO\n-\tO\ncalcineurin\tO\ncomplexes\tO\nformed\tO\nonly\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nCsA\tB-Chemical\nand\tO\nFK506\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nrapamycin\tB-Chemical\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nthe\tO\nnephrotoxic\tB-Disease\neffects\tO\nof\tO\nCsA\tB-Chemical\nand\tO\nFK506\tB-Chemical\nis\tO\nlikely\tO\nmediated\tO\nthrough\tO\nbinding\tO\nto\tO\nrenal\tO\nimmunophilin\tO\nand\tO\ninhibiting\tO\ncalcineurin\tO\nphosphatase\tO\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nin\tO\nhigh\tO\ndose\tO\ncarboplatin\tB-Chemical\nchemotherapy\tO\n.\tO\n\nCarboplatin\tB-Chemical\nhas\tO\nbeen\tO\nreported\tO\nto\tO\ncause\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nwhen\tO\nadministered\tO\nin\tO\nhigh\tO\ndoses\tO\nto\tO\nadult\tO\npatients\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\n4\tO\n1\tO\n/\tO\n2\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ngirl\tO\nwho\tO\nwas\tO\ntreated\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\ncarboplatin\tB-Chemical\nfor\tO\nmetastatic\tO\nparameningeal\tO\nembryonal\tB-Disease\nrhabdomyosarcoma\tI-Disease\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\ndeveloped\tO\nfollowed\tO\nby\tO\na\tO\nslow\tO\npartial\tO\nrecovery\tO\nof\tO\nrenal\tO\nfunction\tO\n.\tO\n\nPossible\tO\ncontributing\tO\nfactors\tO\nare\tO\ndiscussed\tO\n.\tO\n\nClinical\tO\nevaluation\tO\non\tO\ncombined\tO\nadministration\tO\nof\tO\noral\tO\nprostacyclin\tB-Chemical\nanalogue\tO\nberaprost\tB-Chemical\nand\tO\nphosphodiesterase\tO\ninhibitor\tO\ncilostazol\tB-Chemical\n.\tO\n\nAmong\tO\nvarious\tO\noral\tO\nantiplatelets\tO\n,\tO\na\tO\ncombination\tO\nof\tO\na\tO\nnovel\tO\nprostacyclin\tB-Chemical\nanalogue\tO\nberaprost\tB-Chemical\n(\tO\nBPT\tB-Chemical\n)\tO\nand\tO\na\tO\npotent\tO\nphosphodiesterase\tO\ninhibitor\tO\ncilostazol\tB-Chemical\n(\tO\nCLZ\tB-Chemical\n)\tO\nmay\tO\nresult\tO\nin\tO\nuntoward\tO\nclinical\tO\neffects\tO\ndue\tO\nto\tO\npossible\tO\nsynergistic\tO\nelevation\tO\nof\tO\nintracellular\tO\ncAMP\tB-Chemical\n(\tO\ncyclic\tB-Chemical\nadenosine\tI-Chemical\n3\tI-Chemical\n'\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\nmonophosphate\tI-Chemical\n)\tO\n.\tO\n\nThereby\tO\n,\tO\na\tO\nclinical\tO\nstudy\tO\nof\tO\nthe\tO\ncombined\tO\nadministration\tO\nof\tO\nthe\tO\ntwo\tO\nagents\tO\nwas\tO\nattempted\tO\n.\tO\n\nTwelve\tO\nhealthy\tO\nvolunteers\tO\nwere\tO\nassigned\tO\nto\tO\ntake\tO\nBPT\tB-Chemical\n/\tO\nCLZ\tB-Chemical\nin\tO\nthe\tO\nfollowing\tO\nschedule\tO\n;\tO\nBPT\tB-Chemical\n:\tO\n40\tO\nmicrograms\tO\nat\tO\nday\tO\n1\tO\nand\tO\n120\tO\nmicrograms\tO\nt\tO\n.\tO\ni\tO\n.\tO\nd\tO\n.\tO\nfrom\tO\nday\tO\n7\tO\nto\tO\n14\tO\n,\tO\nCLZ\tB-Chemical\n:\tO\n200\tO\nmg\tO\nt\tO\n.\tO\ni\tO\n.\tO\nd\tO\n.\tO\nfrom\tO\nday\tO\n3\tO\nto\tO\n14\tO\n.\tO\n\nAt\tO\nvarious\tO\ntime\tO\nintervals\tO\n,\tO\nphysical\tO\nexamination\tO\nand\tO\nblood\tO\ncollection\tO\nfor\tO\nex\tO\nvivo\tO\nplatelet\tB-Disease\naggregation\tI-Disease\nand\tO\ndetermination\tO\nof\tO\nintraplatelet\tO\ncAMP\tB-Chemical\nwere\tO\nperformed\tO\n.\tO\n\nThroughout\tO\nthe\tO\nobservation\tO\nperiod\tO\n,\tO\nno\tO\nsignificant\tO\nalteration\tO\nin\tO\nvital\tO\nsigns\tO\nwas\tO\nobserved\tO\n.\tO\n\nSeven\tO\nout\tO\nof\tO\n12\tO\nsubjects\tO\nexperienced\tO\nheadache\tB-Disease\nof\tO\na\tO\nshort\tO\nduration\tO\naccompanying\tO\nfacial\tB-Disease\nflush\tI-Disease\nin\tO\none\tO\nand\tO\nnausea\tB-Disease\nin\tO\none\tO\n,\tO\nespecially\tO\nafter\tO\ningestion\tO\nof\tO\nCLZ\tB-Chemical\n.\tO\n\nAll\tO\nof\tO\nthese\tO\nsymptoms\tO\n,\tO\nprobably\tO\ncaused\tO\nby\tO\nthe\tO\nvasodilating\tO\neffect\tO\nof\tO\nthe\tO\ntwo\tO\nagents\tO\n,\tO\nwere\tO\nof\tO\nmild\tO\ndegree\tO\nand\tO\nno\tO\nspecial\tO\ntreatment\tO\nwas\tO\nrequired\tO\n.\tO\n\nIntraplatelet\tO\ncAMP\tB-Chemical\ncontent\tO\nwas\tO\ngradually\tO\nbut\tO\nsignificantly\tO\nincreased\tO\nto\tO\n9\tO\n.\tO\n84\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n59\tO\npmol\tO\nper\tO\n10\tO\n(\tO\n9\tO\n)\tO\nplatelets\tO\nat\tO\nday\tO\n14\tO\nin\tO\ncomparison\tO\nwith\tO\nthe\tO\ninitial\tO\nvalue\tO\n(\tO\n6\tO\n.\tO\n87\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n25\tO\npmol\tO\n)\tO\n.\tO\n\nThe\tO\nplatelet\tO\naggregability\tO\nwas\tO\nsignificantly\tO\nsuppressed\tO\nat\tO\nvarious\tO\ntime\tO\nintervals\tO\nbut\tO\nno\tO\nadditive\tO\nor\tO\nsynergistic\tO\ninhibitory\tO\neffect\tO\nby\tO\nthe\tO\ncombined\tO\nadministration\tO\nwas\tO\nnoted\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\ncombined\tO\nadministration\tO\nof\tO\nBPT\tB-Chemical\n/\tO\nCLZ\tB-Chemical\nis\tO\nsafe\tO\nat\tO\ndoses\tO\nused\tO\nin\tO\nthe\tO\nstudy\tO\n,\tO\nthough\tO\nthe\tO\nbeneficial\tO\nclinical\tO\neffect\tO\nof\tO\nthe\tO\ncombined\tO\nadministration\tO\nhas\tO\nyet\tO\nto\tO\nbe\tO\nelucidated\tO\n.\tO\n\nPravastatin\tB-Chemical\n-\tO\nassociated\tO\nmyopathy\tB-Disease\n.\tO\n\nReport\tO\nof\tO\na\tO\ncase\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nacute\tO\ninflammatory\tB-Disease\nmyopathy\tI-Disease\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\npravastatin\tB-Chemical\n,\tO\na\tO\nnew\tO\nhydrophilic\tO\n3\tO\n-\tO\nhydroxy\tO\n-\tO\n3\tO\nmethylglutaril\tO\ncoenzyme\tO\nA\tO\nreductase\tO\ninhibitor\tO\n,\tO\nis\tO\nreported\tO\n.\tO\n\nThe\tO\npatient\tO\n,\tO\na\tO\n69\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwas\tO\naffected\tO\nby\tO\nnon\tB-Disease\n-\tI-Disease\ninsulin\tI-Disease\n-\tI-Disease\ndependent\tI-Disease\ndiabetes\tI-Disease\nmellitus\tI-Disease\nand\tO\nhypertension\tB-Disease\n.\tO\n\nHe\tO\nassumed\tO\npravastatin\tB-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nbecause\tO\nof\tO\nhypercholesterolemia\tB-Disease\n.\tO\n\nHe\tO\nwas\tO\nadmitted\tO\nwith\tO\nacute\tO\nmyopathy\tB-Disease\nof\tO\nthe\tO\nlower\tO\nlimbs\tO\nwhich\tO\nresolved\tO\nin\tO\na\tO\nfew\tO\ndays\tO\nafter\tO\npravastatin\tB-Chemical\ndiscontinuation\tO\n.\tO\n\nA\tO\npreviously\tO\nunknown\tO\nhypothyroidism\tB-Disease\n,\tO\nprobably\tO\ndue\tO\nto\tO\nchronic\tO\nautoimmune\tB-Disease\nthyroiditis\tI-Disease\n,\tO\nwas\tO\nevidenced\tO\n.\tO\n\nMuscle\tO\nbiopsy\tO\n(\tO\nleft\tO\ngastrocnemius\tO\n)\tO\nrevealed\tO\na\tO\nperimysial\tO\nand\tO\nendomysial\tO\ninflammatory\tO\ninfiltrate\tO\nwith\tO\na\tO\nprevalence\tO\nof\tO\nCD4\tO\n+\tO\nlymphocytes\tO\n.\tO\n\nWhile\tO\nlovastatin\tB-Chemical\nand\tO\nsimvastatin\tB-Chemical\nhave\tO\nbeen\tO\nassociated\tO\nwith\tO\ntoxic\tO\nmyopathy\tB-Disease\n,\tO\npravastatin\tB-Chemical\n-\tO\nassociated\tO\nmyopathy\tB-Disease\ncould\tO\nrepresent\tO\na\tO\ndistinct\tO\n,\tO\ninflammatory\tO\nentity\tO\n.\tO\n\nReversal\tO\nof\tO\nammonia\tB-Chemical\ncoma\tB-Disease\nin\tO\nrats\tO\nby\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n:\tO\na\tO\nperipheral\tO\neffect\tO\n.\tO\n\nAmmonia\tB-Chemical\ncoma\tB-Disease\nwas\tO\nproduced\tO\nin\tO\nrats\tO\nwithin\tO\n10\tO\nto\tO\n15\tO\nminutes\tO\nof\tO\nan\tO\nintraperitonealinjection\tO\nof\tO\n1\tO\n.\tO\n7\tO\nmmol\tO\nNH4CL\tB-Chemical\n.\tO\n\nThis\tO\ncoma\tB-Disease\nwas\tO\nprevented\tO\nwith\tO\n1\tO\n.\tO\n68\tO\nmmol\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\ngiven\tO\nby\tO\ngastric\tO\nintubation\tO\n15\tO\nminutes\tO\nbefore\tO\nthe\tO\nammonium\tB-Chemical\nsalt\tI-Chemical\ninjection\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nwas\tO\ncorrelated\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\nblood\tO\nand\tO\nbrain\tO\nammonia\tB-Chemical\n,\tO\nan\tO\nincrease\tO\nin\tO\nbrain\tO\ndopamine\tB-Chemical\n,\tO\nand\tO\nan\tO\nincrease\tO\nin\tO\nrenal\tO\nexcretion\tO\nof\tO\nammonia\tB-Chemical\nand\tO\nurea\tB-Chemical\n.\tO\n\nIntraventricular\tO\ninfusion\tO\nof\tO\ndopamine\tB-Chemical\nsufficient\tO\nto\tO\nraise\tO\nthe\tO\nbrain\tO\ndopamine\tB-Chemical\nto\tO\nthe\tO\nsame\tO\nextent\tO\ndid\tO\nnot\tO\nprevent\tO\nthe\tO\nammonia\tB-Chemical\ncoma\tB-Disease\nnor\tO\naffect\tO\nthe\tO\nblood\tO\nand\tO\nbrain\tO\nammonia\tB-Chemical\nconcentrations\tO\n.\tO\n\nBilateral\tO\nnephrectomy\tO\neliminated\tO\nthe\tO\nbeneficial\tO\neffect\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\non\tO\nblood\tO\nand\tO\nbrain\tO\nammonia\tB-Chemical\nand\tO\nthe\tO\nammonia\tB-Chemical\ncoma\tB-Disease\nwas\tO\nnot\tO\nprevented\tO\n.\tO\n\nThus\tO\n,\tO\nthe\tO\nreduction\tO\nin\tO\nblood\tO\nand\tO\nbrain\tO\nammonia\tB-Chemical\nand\tO\nthe\tO\nprevention\tO\nof\tO\nammonia\tB-Chemical\ncoma\tB-Disease\nafter\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n,\tO\ncan\tO\nbe\tO\naccounted\tO\nfor\tO\nby\tO\nthe\tO\nperipheral\tO\neffect\tO\nof\tO\ndopamine\tB-Chemical\non\tO\nrenal\tO\nfunction\tO\nrather\tO\nthan\tO\nits\tO\ncentral\tO\naction\tO\n.\tO\n\nThese\tO\nresults\tO\nprovide\tO\na\tO\nreasonable\tO\nexplanation\tO\nfor\tO\nthe\tO\nbeneficial\tO\neffects\tO\nobserved\tO\nin\tO\nsome\tO\nencephalopathic\tB-Disease\npatients\tO\nreceiving\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n.\tO\n\nEtoposide\tB-Chemical\n-\tO\nrelated\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nThe\tO\noccurrence\tO\nof\tO\na\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nis\tO\nreported\tO\nafter\tO\nchemotherapy\tO\ncontaining\tO\netoposide\tB-Chemical\n,\tO\nin\tO\na\tO\nman\tO\nwith\tO\nno\tO\nrisk\tO\nfactors\tO\nfor\tO\ncoronary\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n.\tO\n\nPossible\tO\ncausal\tO\nmechanisms\tO\nare\tO\ndiscussed\tO\n.\tO\n\nHalogenated\tO\nanesthetics\tO\nform\tO\nliver\tO\nadducts\tO\nand\tO\nantigens\tO\nthat\tO\ncross\tO\n-\tO\nreact\tO\nwith\tO\nhalothane\tB-Chemical\n-\tO\ninduced\tO\nantibodies\tO\n.\tO\n\nTwo\tO\nhalogenated\tO\nanesthetics\tO\n,\tO\nenflurane\tB-Chemical\nand\tO\nisoflurane\tB-Chemical\n,\tO\nhave\tO\nbeen\tO\nassociated\tO\nwith\tO\nan\tO\nallergic\tO\n-\tO\ntype\tO\nhepatic\tB-Disease\ninjury\tI-Disease\nboth\tO\nalone\tO\nand\tO\nfollowing\tO\nprevious\tO\nexposure\tO\nto\tO\nhalothane\tB-Chemical\n.\tO\n\nHalothane\tB-Chemical\nhepatitis\tB-Disease\nappears\tO\nto\tO\ninvolve\tO\nan\tO\naberrant\tO\nimmune\tO\nresponse\tO\n.\tO\n\nAn\tO\nantibody\tO\nresponse\tO\nto\tO\na\tO\nprotein\tO\n-\tO\nbound\tO\nbiotransformation\tO\nproduct\tO\n(\tO\ntrifluoroacetyl\tB-Chemical\nadduct\tO\n)\tO\nhas\tO\nbeen\tO\ndetected\tO\non\tO\nhalothane\tB-Chemical\nhepatitis\tB-Disease\npatients\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nperformed\tO\nto\tO\ndetermine\tO\ncross\tO\n-\tO\nreactivity\tO\nbetween\tO\nenflurane\tB-Chemical\nand\tO\nisoflurane\tB-Chemical\nwith\tO\nthe\tO\nhypersensitivity\tB-Disease\ninduced\tO\nby\tO\nhalothane\tB-Chemical\n.\tO\n\nThe\tO\nsubcellular\tO\nand\tO\nlobular\tO\nproduction\tO\nof\tO\nhepatic\tO\nneoantigens\tO\nrecognized\tO\nby\tO\nhalothane\tB-Chemical\n-\tO\ninduced\tO\nantibodies\tO\nfollowing\tO\nenflurane\tB-Chemical\nand\tO\nisoflurane\tB-Chemical\n,\tO\nand\tO\nthe\tO\nbiochemical\tO\nnature\tO\nof\tO\nthese\tO\nneoantigens\tO\nwas\tO\ninvestigated\tO\nin\tO\ntwo\tO\nanimal\tO\nmodels\tO\n.\tO\n\nEnflurane\tB-Chemical\nadministration\tO\nresulted\tO\nin\tO\nneoantigens\tO\ndetected\tO\nin\tO\nboth\tO\nthe\tO\nmicrosomal\tO\nand\tO\ncytosolic\tO\nfraction\tO\nof\tO\nliver\tO\nhomogenates\tO\nand\tO\nin\tO\nthe\tO\ncentrilobular\tO\nregion\tO\nof\tO\nthe\tO\nliver\tO\n.\tO\n\nIn\tO\nthe\tO\nsame\tO\nliver\tO\n,\tO\nbiochemical\tO\nanalysis\tO\ndetected\tO\nfluorinated\tO\nliver\tO\nadducts\tO\nthat\tO\nwere\tO\nup\tO\nto\tO\n20\tO\n-\tO\nfold\tO\ngreater\tO\nin\tO\nguinea\tO\npigs\tO\nthan\tO\nin\tO\nrats\tO\n.\tO\n\nThis\tO\nsupports\tO\nand\tO\nextends\tO\nprevious\tO\nevidence\tO\nfor\tO\na\tO\nmechanism\tO\nby\tO\nwhich\tO\nenflurane\tB-Chemical\nand\tO\n/\tO\nor\tO\nisoflurane\tB-Chemical\ncould\tO\nproduce\tO\na\tO\nhypersensitivity\tB-Disease\ncondition\tO\nsimilar\tO\nto\tO\nthat\tO\nof\tO\nhalothane\tB-Chemical\nhepatitis\tB-Disease\neither\tO\nalone\tO\nor\tO\nsubsequent\tO\nto\tO\nhalothane\tB-Chemical\nadministration\tO\n.\tO\n\nThe\tO\nguinea\tO\npig\tO\nwould\tO\nappear\tO\nto\tO\nbe\tO\na\tO\nuseful\tO\nmodel\tO\nfor\tO\nfurther\tO\ninvestigations\tO\nof\tO\nthe\tO\nimmunological\tO\nresponse\tO\nto\tO\nthese\tO\nantigens\tO\n.\tO\n\nCholinergic\tO\ntoxicity\tB-Disease\nresulting\tO\nfrom\tO\nocular\tO\ninstillation\tO\nof\tO\nechothiophate\tB-Chemical\niodide\tI-Chemical\neye\tO\ndrops\tO\n.\tO\n\nA\tO\npatient\tO\ndeveloped\tO\na\tO\nsevere\tO\ncholinergic\tO\nsyndrome\tO\nfrom\tO\nthe\tO\nuse\tO\nof\tO\nechothiophate\tB-Chemical\niodide\tI-Chemical\nophthalmic\tO\ndrops\tO\n,\tO\npresented\tO\nwith\tO\nprofound\tO\nmuscle\tB-Disease\nweakness\tI-Disease\nand\tO\nwas\tO\ninitially\tO\ngiven\tO\nthe\tO\ndiagnosis\tO\nof\tO\nmyasthenia\tB-Disease\ngravis\tI-Disease\n.\tO\n\nRed\tO\nblood\tO\ncell\tO\nand\tO\nserum\tO\ncholinesterase\tO\nlevels\tO\nwere\tO\nseverely\tO\ndepressed\tO\nand\tO\nsymptoms\tO\nresolved\tO\nspontaneously\tO\nfollowing\tO\ndiscontinuation\tO\nof\tO\nthe\tO\neye\tO\ndrops\tO\n.\tO\n\nSeizure\tB-Disease\nafter\tO\nflumazenil\tB-Chemical\nadministration\tO\nin\tO\na\tO\npediatric\tO\npatient\tO\n.\tO\n\nFlumazenil\tB-Chemical\nis\tO\na\tO\nbenzodiazepine\tB-Chemical\nreceptor\tO\nantagonist\tO\nused\tO\nto\tO\nreverse\tO\nsedation\tO\nand\tO\nrespiratory\tB-Disease\ndepression\tI-Disease\ninduced\tO\nby\tO\nbenzodiazepines\tB-Chemical\n.\tO\n\nSeizures\tB-Disease\nand\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\nhave\tO\ncomplicated\tO\nits\tO\nuse\tO\nin\tO\nadult\tO\npatients\tO\n.\tO\n\nOverdose\tB-Disease\npatients\tO\nwho\tO\nhave\tO\ncoingested\tO\ntricyclic\tO\nantidepressants\tO\nhave\tO\na\tO\nhigher\tO\nrisk\tO\nof\tO\nthese\tO\ncomplications\tO\n.\tO\n\nLittle\tO\ninformation\tO\nexists\tO\nconcerning\tO\nadverse\tO\neffects\tO\nof\tO\nflumazenil\tB-Chemical\nin\tO\nchildren\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\noccurrence\tO\nof\tO\na\tO\ngeneralized\tO\ntonic\tB-Disease\n-\tI-Disease\nclonic\tI-Disease\nseizure\tI-Disease\nin\tO\na\tO\npediatric\tO\npatient\tO\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nflumazenil\tB-Chemical\n.\tO\n\nPhase\tO\nI\tO\ntrial\tO\nof\tO\n13\tB-Chemical\n-\tI-Chemical\ncis\tI-Chemical\n-\tI-Chemical\nretinoic\tI-Chemical\nacid\tI-Chemical\nin\tO\nchildren\tO\nwith\tO\nneuroblastoma\tB-Disease\nfollowing\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTreatment\tO\nof\tO\nneuroblastoma\tB-Disease\ncell\tO\nlines\tO\nwith\tO\n13\tB-Chemical\n-\tI-Chemical\ncis\tI-Chemical\n-\tI-Chemical\nretinoic\tI-Chemical\nacid\tI-Chemical\n(\tO\ncis\tB-Chemical\n-\tI-Chemical\nRA\tI-Chemical\n)\tO\ncan\tO\ncause\tO\nsustained\tO\ninhibition\tO\nof\tO\nproliferation\tO\n.\tO\n\nSince\tO\ncis\tB-Chemical\n-\tI-Chemical\nRA\tI-Chemical\nhas\tO\ndemonstrated\tO\nclinical\tO\nresponses\tO\nin\tO\nneuroblastoma\tB-Disease\npatients\tO\n,\tO\nit\tO\nmay\tO\nbe\tO\neffective\tO\nin\tO\npreventing\tO\nrelapse\tO\nafter\tO\ncytotoxic\tO\ntherapy\tO\n.\tO\n\nThis\tO\nphase\tO\nI\tO\ntrial\tO\nwas\tO\ndesigned\tO\nto\tO\ndetermine\tO\nthe\tO\nmaximal\tO\n-\tO\ntolerated\tO\ndosage\tO\n(\tO\nMTD\tO\n)\tO\n,\tO\ntoxicities\tB-Disease\n,\tO\nand\tO\npharmacokinetics\tO\nof\tO\ncis\tB-Chemical\n-\tI-Chemical\nRA\tI-Chemical\nadministered\tO\non\tO\nan\tO\nintermittent\tO\nschedule\tO\nin\tO\nchildren\tO\nwith\tO\nneuroblastoma\tB-Disease\nfollowing\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\n(\tO\nBMT\tO\n)\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nFifty\tO\n-\tO\none\tO\nassessable\tO\npatients\tO\n,\tO\n2\tO\nto\tO\n12\tO\nyears\tO\nof\tO\nage\tO\n,\tO\nwere\tO\ntreated\tO\nwith\tO\noral\tO\ncis\tB-Chemical\n-\tI-Chemical\nRA\tI-Chemical\nadministered\tO\nin\tO\ntwo\tO\nequally\tO\ndivided\tO\ndoses\tO\ndaily\tO\nfor\tO\n2\tO\nweeks\tO\n,\tO\nfollowed\tO\nby\tO\na\tO\n2\tO\n-\tO\nweek\tO\nrest\tO\nperiod\tO\n,\tO\nfor\tO\nup\tO\nto\tO\n12\tO\ncourses\tO\n.\tO\n\nThe\tO\ndose\tO\nwas\tO\nescalated\tO\nfrom\tO\n100\tO\nto\tO\n200\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nd\tO\nuntil\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicity\tB-Disease\n(\tO\nDLT\tO\n)\tO\nwas\tO\nobserved\tO\n.\tO\n\nA\tO\nsingle\tO\nintrapatient\tO\ndose\tO\nescalation\tO\nwas\tO\npermitted\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nMTD\tO\nof\tO\ncis\tB-Chemical\n-\tI-Chemical\nRA\tI-Chemical\nwas\tO\n160\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nd\tO\n.\tO\n\nDose\tO\n-\tO\nlimiting\tO\ntoxicities\tB-Disease\nin\tO\nsix\tO\nof\tO\nnine\tO\npatients\tO\nat\tO\n200\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nd\tO\nincluded\tO\nhypercalcemia\tB-Disease\n(\tO\nn\tO\n=\tO\n3\tO\n)\tO\n,\tO\nrash\tB-Disease\n(\tO\nn\tO\n=\tO\n2\tO\n)\tO\n,\tO\nand\tO\nanemia\tB-Disease\n/\tO\nthrombocytopenia\tB-Disease\n/\tO\nemesis\tB-Disease\n/\tO\nrash\tB-Disease\n(\tO\nn\tO\n=\tO\n1\tO\n)\tO\n.\tO\n\nAll\tO\ntoxicities\tB-Disease\nresolved\tO\nafter\tO\ncis\tB-Chemical\n-\tI-Chemical\nRA\tI-Chemical\nwas\tO\ndiscontinued\tO\n.\tO\n\nThree\tO\ncomplete\tO\nresponses\tO\nwere\tO\nobserved\tO\nin\tO\nmarrow\tO\nmetastases\tB-Disease\n.\tO\n\nSerum\tO\nlevels\tO\nof\tO\n7\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n0\tO\nmumol\tO\n/\tO\nL\tO\n(\tO\npeak\tO\n)\tO\nand\tO\n4\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n8\tO\nmumol\tO\n/\tO\nL\tO\n(\tO\ntrough\tO\n)\tO\nat\tO\nthe\tO\nMTD\tO\nwere\tO\nmaintained\tO\nduring\tO\n14\tO\ndays\tO\nof\tO\ntherapy\tO\n.\tO\n\nThe\tO\nDLT\tO\ncorrelated\tO\nwith\tO\nserum\tO\nlevels\tO\n>\tO\nor\tO\n=\tO\n10\tO\nmumol\tO\n/\tO\nL\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nMTD\tO\nof\tO\ncis\tB-Chemical\n-\tI-Chemical\nRA\tI-Chemical\ngiven\tO\non\tO\nthis\tO\nintermittent\tO\nschedule\tO\nwas\tO\n160\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nd\tO\n.\tO\n\nSerum\tO\nlevels\tO\nknown\tO\nto\tO\nbe\tO\neffective\tO\nagainst\tO\nneuroblastoma\tB-Disease\nin\tO\nvitro\tO\nwere\tO\nachieved\tO\nat\tO\nthis\tO\ndose\tO\n.\tO\n\nThe\tO\nDLT\tO\nincluded\tO\nhypercalcemia\tB-Disease\n,\tO\nand\tO\nmay\tO\nbe\tO\npredicted\tO\nby\tO\nserum\tO\ncis\tB-Chemical\n-\tI-Chemical\nRA\tI-Chemical\nlevels\tO\n.\tO\n\nMonitoring\tO\nof\tO\nserum\tO\ncalcium\tB-Chemical\nand\tO\ncis\tB-Chemical\n-\tI-Chemical\nRA\tI-Chemical\nlevels\tO\nis\tO\nindicated\tO\nin\tO\nfuture\tO\ntrials\tO\n.\tO\n\nTime\tO\ndependence\tO\nof\tO\nplasma\tO\nmalondialdehyde\tB-Chemical\n,\tO\noxypurines\tB-Chemical\n,\tO\nand\tO\nnucleosides\tB-Chemical\nduring\tO\nincomplete\tO\ncerebral\tB-Disease\nischemia\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nIncomplete\tO\ncerebral\tB-Disease\nischemia\tI-Disease\n(\tO\n30\tO\nmin\tO\n)\tO\nwas\tO\ninduced\tO\nin\tO\nthe\tO\nrat\tO\nby\tO\nbilaterally\tO\nclamping\tO\nthe\tO\ncommon\tO\ncarotid\tO\narteries\tO\n.\tO\n\nPeripheral\tO\nvenous\tO\nblood\tO\nsamples\tO\nwere\tO\nwithdrawn\tO\nfrom\tO\nthe\tO\nfemoral\tO\nvein\tO\nfour\tO\ntimes\tO\n(\tO\nonce\tO\nevery\tO\n5\tO\nmin\tO\n)\tO\nbefore\tO\nischemia\tB-Disease\n(\tO\n0\tO\ntime\tO\n)\tO\nand\tO\n5\tO\n,\tO\n15\tO\n,\tO\nand\tO\n30\tO\nmin\tO\nafter\tO\nischemia\tB-Disease\n.\tO\n\nPlasma\tO\nextracts\tO\nwere\tO\nanalyzed\tO\nby\tO\na\tO\nhighly\tO\nsensitive\tO\nhigh\tO\n-\tO\nperformance\tO\nliquid\tO\nchromatographic\tO\nmethod\tO\nfor\tO\nthe\tO\ndirect\tO\ndetermination\tO\nof\tO\nmalondialdehyde\tB-Chemical\n,\tO\noxypurines\tB-Chemical\n,\tO\nand\tO\nnucleosides\tB-Chemical\n.\tO\n\nDuring\tO\nischemia\tB-Disease\n,\tO\na\tO\ntime\tO\n-\tO\ndependent\tO\nincrease\tO\nof\tO\nplasma\tO\noxypurines\tB-Chemical\nand\tO\nnucleosides\tB-Chemical\nwas\tO\nobserved\tO\n.\tO\n\nPlasma\tO\nmalondialdehyde\tB-Chemical\n,\tO\nwhich\tO\nwas\tO\npresent\tO\nin\tO\nminimal\tO\namount\tO\nat\tO\nzero\tO\ntime\tO\n(\tO\n0\tO\n.\tO\n058\tO\nmumol\tO\n/\tO\nliter\tO\nplasma\tO\n;\tO\nSD\tO\n0\tO\n.\tO\n015\tO\n)\tO\n,\tO\nincreased\tO\nafter\tO\n5\tO\nmin\tO\nof\tO\nischemia\tB-Disease\n,\tO\nresulting\tO\nin\tO\na\tO\nfivefold\tO\nincrease\tO\nafter\tO\n30\tO\nmin\tO\nof\tO\ncarotid\tO\nocclusion\tO\n(\tO\n0\tO\n.\tO\n298\tO\nmumol\tO\n/\tO\nliter\tO\nplasma\tO\n;\tO\nSD\tO\n0\tO\n.\tO\n078\tO\n)\tO\n.\tO\n\nIncreased\tO\nplasma\tO\nmalondialdehyde\tB-Chemical\nwas\tO\nalso\tO\nrecorded\tO\nin\tO\ntwo\tO\nother\tO\ngroups\tO\nof\tO\nanimals\tO\nsubjected\tO\nto\tO\nthe\tO\nsame\tO\nexperimental\tO\nmodel\tO\n,\tO\none\tO\nreceiving\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\nb\tO\n.\tO\nw\tO\n.\tO\nof\tO\nthe\tO\ncyclooxygenase\tO\ninhibitor\tO\nacetylsalicylate\tB-Chemical\nintravenously\tO\nimmediately\tO\nbefore\tO\nischemia\tB-Disease\n,\tO\nthe\tO\nother\tO\nreceiving\tO\n650\tO\nmicrograms\tO\n/\tO\nkg\tO\nb\tO\n.\tO\nw\tO\n.\tO\nof\tO\nthe\tO\nhypotensive\tB-Disease\ndrug\tO\nnitroprusside\tB-Chemical\nat\tO\na\tO\nflow\tO\nrate\tO\nof\tO\n103\tO\nmicroliters\tO\n/\tO\nmin\tO\nintravenously\tO\nduring\tO\nischemia\tB-Disease\n,\tO\nalthough\tO\nin\tO\nthis\tO\nlatter\tO\ngroup\tO\nmalondialdehyde\tB-Chemical\nwas\tO\nsignificantly\tO\nhigher\tO\n.\tO\n\nThe\tO\npresent\tO\ndata\tO\nindicate\tO\nthat\tO\nthe\tO\ndetermination\tO\nof\tO\nmalondialdehyde\tB-Chemical\n,\tO\noxypurines\tB-Chemical\n,\tO\nand\tO\nnucleosides\tB-Chemical\nin\tO\nperipheral\tO\nblood\tO\n,\tO\nmay\tO\nbe\tO\nused\tO\nto\tO\nmonitor\tO\nthe\tO\nmetabolic\tO\nalterations\tO\nof\tO\ntissues\tO\noccurring\tO\nduring\tO\nischemic\tB-Disease\nphenomena\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nAcute\tO\nrenal\tB-Disease\ntoxicity\tI-Disease\nof\tO\ndoxorubicin\tB-Chemical\n(\tO\nadriamycin\tB-Chemical\n)\tO\n-\tO\nloaded\tO\ncyanoacrylate\tB-Chemical\nnanoparticles\tO\n.\tO\n\nAcute\tO\ndoxorubicin\tB-Chemical\n-\tO\nloaded\tO\nnanoparticle\tO\n(\tO\nDXNP\tO\n)\tO\nrenal\tB-Disease\ntoxicity\tI-Disease\nwas\tO\nexplored\tO\nin\tO\nboth\tO\nnormal\tO\nrats\tO\nand\tO\nrats\tO\nwith\tO\nexperimental\tO\nglomerulonephritis\tB-Disease\n.\tO\n\nIn\tO\nnormal\tO\nrats\tO\n,\tO\n2\tO\n/\tO\n6\tO\nrats\tO\ngiven\tO\nfree\tO\ndoxorubicin\tB-Chemical\n(\tO\nDX\tB-Chemical\n)\tO\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ndied\tO\nwithin\tO\none\tO\nweek\tO\n,\tO\nwhereas\tO\nall\tO\ncontrol\tO\nanimals\tO\nand\tO\nall\tO\nrats\tO\nhaving\tO\nreceived\tO\nfree\tO\nNP\tO\nor\tO\nDXNP\tO\nsurvived\tO\n.\tO\n\nA\tO\n3\tO\ntimes\tO\nhigher\tO\nproteinuria\tB-Disease\nappeared\tO\nin\tO\nanimals\tO\ntreated\tO\nwith\tO\nDXNP\tO\nthan\tO\nin\tO\nthose\tO\ntreated\tO\nwith\tO\nDX\tB-Chemical\n.\tO\n\nFree\tO\nNP\tO\ndid\tO\nnot\tO\nprovoke\tO\nany\tO\nproteinuria\tB-Disease\n.\tO\n\nTwo\tO\nhr\tO\npost\tO\n-\tO\ninjection\tO\n,\tO\nDXNP\tO\nwas\tO\n2\tO\n.\tO\n7\tO\ntimes\tO\nmore\tO\nconcentrated\tO\nin\tO\nkidneys\tO\nthan\tO\nfree\tO\nDX\tB-Chemical\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nIn\tO\nrats\tO\nwith\tO\nimmune\tO\nexperimental\tO\nglomerulonephritis\tB-Disease\n,\tO\n5\tO\n/\tO\n6\tO\nrats\tO\ngiven\tO\nDX\tB-Chemical\ndied\tO\nwithin\tO\n7\tO\ndays\tO\n,\tO\nin\tO\ncontrast\tO\nto\tO\nanimals\tO\ntreated\tO\nby\tO\nDXNP\tO\n,\tO\nNP\tO\n,\tO\nor\tO\nuntreated\tO\n,\tO\nwhich\tO\nall\tO\nsurvived\tO\n.\tO\n\nProteinuria\tB-Disease\nappeared\tO\nin\tO\nall\tO\nseries\tO\n,\tO\nbut\tO\nwas\tO\n2\tO\n-\tO\n5\tO\ntimes\tO\nmore\tO\nintense\tO\n(\tO\np\tO\n>\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\nprolonged\tO\nafter\tO\ndoxorubicin\tB-Chemical\ntreatment\tO\n(\tO\n400\tO\n-\tO\n700\tO\nmg\tO\n/\tO\nday\tO\n)\tO\n,\tO\nwithout\tO\nsignificant\tO\ndifference\tO\nbetween\tO\nDXNP\tO\nand\tO\nDX\tB-Chemical\n.\tO\n\nRats\tO\ntreated\tO\nby\tO\nunloaded\tO\nNP\tO\nbehaved\tO\nas\tO\ncontrols\tO\n.\tO\n\nThese\tO\nresults\tO\ndemonstrate\tO\nthat\tO\n,\tO\nin\tO\nthese\tO\nexperimental\tO\nconditions\tO\n,\tO\nDXNP\tO\nkilled\tO\nless\tO\nanimals\tO\nthan\tO\nfree\tO\nDX\tB-Chemical\n,\tO\ndespite\tO\nof\tO\nan\tO\nenhanced\tO\nrenal\tB-Disease\ntoxicity\tI-Disease\nof\tO\nthe\tO\nformer\tO\n.\tO\n\nBoth\tO\neffects\tO\n(\tO\nbetter\tO\nsurvival\tO\nand\tO\nnephrosis\tB-Disease\n)\tO\nare\tO\nmost\tO\nprobably\tO\nrelated\tO\nto\tO\nan\tO\nenhanced\tO\ncapture\tO\nof\tO\nDXNP\tO\nby\tO\ncells\tO\nof\tO\nthe\tO\nmononuclear\tO\nphagocyte\tO\nsystem\tO\n,\tO\nincluding\tO\nmesangial\tO\ncells\tO\n.\tO\n\nProstaglandin\tB-Chemical\nE2\tI-Chemical\n-\tO\ninduced\tO\nbladder\tB-Disease\nhyperactivity\tI-Disease\nin\tO\nnormal\tO\n,\tO\nconscious\tO\nrats\tO\n:\tO\ninvolvement\tO\nof\tO\ntachykinins\tB-Chemical\n?\tO\n\nIn\tO\nnormal\tO\nconscious\tO\nrats\tO\ninvestigated\tO\nby\tO\ncontinuous\tO\ncystometry\tO\n,\tO\nintravesically\tO\ninstilled\tO\nprostaglandin\tB-Chemical\n(\tI-Chemical\nPG\tI-Chemical\n)\tI-Chemical\nE2\tI-Chemical\nfacilitated\tO\nmicturition\tO\nand\tO\nincreased\tO\nbasal\tO\nintravesical\tO\npressure\tO\n.\tO\n\nThe\tO\neffect\tO\nwas\tO\nattenuated\tO\nby\tO\nboth\tO\nthe\tO\nNK1\tO\nreceptor\tO\nselective\tO\nantagonist\tO\nRP\tB-Chemical\n67\tI-Chemical\n,\tI-Chemical\n580\tI-Chemical\nand\tO\nthe\tO\nNK2\tO\nreceptor\tO\nselective\tO\nantagonist\tO\nSR\tB-Chemical\n48\tI-Chemical\n,\tI-Chemical\n968\tI-Chemical\n,\tO\ngiven\tO\nintra\tO\n-\tO\narterially\tO\n,\tO\nsuggesting\tO\nthat\tO\nit\tO\nwas\tO\nmediated\tO\nby\tO\nstimulation\tO\nof\tO\nboth\tO\nNK1\tO\nand\tO\nNK2\tO\nreceptors\tO\n.\tO\n\nIntra\tO\n-\tO\narterially\tO\ngiven\tO\nPGE2\tB-Chemical\nproduced\tO\na\tO\ndistinct\tO\nincrease\tO\nin\tO\nbladder\tO\npressure\tO\nbefore\tO\ninitiating\tO\na\tO\nmicturition\tO\nreflex\tO\n,\tO\nindicating\tO\nthat\tO\nthe\tO\nPG\tB-Chemical\nhad\tO\na\tO\ndirect\tO\ncontractant\tO\neffect\tO\non\tO\nthe\tO\ndetrusor\tO\nsmooth\tO\nmuscle\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nintra\tO\n-\tO\narterial\tO\nPGE2\tB-Chemical\ncould\tO\nnot\tO\nbe\tO\nblocked\tO\nby\tO\nintra\tO\n-\tO\narterial\tO\nRP\tB-Chemical\n67\tI-Chemical\n,\tI-Chemical\n580\tI-Chemical\nor\tO\nSR\tB-Chemical\n48\tI-Chemical\n,\tI-Chemical\n968\tI-Chemical\n,\tO\nwhich\tO\nopens\tO\nthe\tO\npossibility\tO\nthat\tO\nthe\tO\nmicturition\tO\nreflex\tO\nelicited\tO\nby\tO\nintra\tO\n-\tO\narterial\tO\nPGE2\tB-Chemical\nwas\tO\nmediated\tO\nby\tO\npathways\tO\nother\tO\nthan\tO\nthe\tO\nreflex\tO\ninitiated\tO\nwhen\tO\nthe\tO\nPG\tB-Chemical\nwas\tO\ngiven\tO\nintravesically\tO\n.\tO\n\nThe\tO\npresent\tO\nresults\tO\nthus\tO\nsuggest\tO\nthat\tO\nintra\tO\n-\tO\narterial\tO\nPGE2\tB-Chemical\n,\tO\ngiven\tO\nnear\tO\nthe\tO\nbladder\tO\n,\tO\nmay\tO\ninitiate\tO\nmicturition\tO\nin\tO\nthe\tO\nnormal\tO\nrat\tO\nchiefly\tO\nby\tO\ndirectly\tO\ncontracting\tO\nthe\tO\nsmooth\tO\nmuscle\tO\nof\tO\nthe\tO\ndetrusor\tO\n.\tO\n\nHowever\tO\n,\tO\nwhen\tO\ngiven\tO\nintravesically\tO\n,\tO\nPGE2\tB-Chemical\nmay\tO\nstimulate\tO\nmicturition\tO\nby\tO\nreleasing\tO\ntachykinins\tB-Chemical\nfrom\tO\nnerves\tO\nin\tO\nand\tO\n/\tO\nor\tO\nimmediately\tO\nbelow\tO\nthe\tO\nurothelium\tO\n.\tO\n\nThese\tO\ntachykinins\tB-Chemical\n,\tO\nin\tO\nturn\tO\n,\tO\ninitiate\tO\na\tO\nmicturition\tO\nreflex\tO\nby\tO\nstimulating\tO\nNK1\tO\nand\tO\nNK2\tO\nreceptors\tO\n.\tO\n\nProstanoids\tB-Chemical\nmay\tO\n,\tO\nvia\tO\nrelease\tO\nof\tO\ntachykinins\tB-Chemical\n,\tO\ncontribute\tO\nto\tO\nboth\tO\nurge\tO\nand\tO\nbladder\tB-Disease\nhyperactivity\tI-Disease\nseen\tO\nin\tO\ninflammatory\tO\nconditions\tO\nof\tO\nthe\tO\nlower\tO\nurinary\tO\ntract\tO\n.\tO\n\nRefractory\tO\ncardiogenic\tB-Disease\nshock\tI-Disease\nand\tO\ncomplete\tO\nheart\tB-Disease\nblock\tI-Disease\nafter\tO\nverapamil\tB-Chemical\nSR\tO\nand\tO\nmetoprolol\tB-Chemical\ntreatment\tO\n.\tO\n\nA\tO\ncase\tO\nreport\tO\n.\tO\n\nA\tO\nseventy\tO\n-\tO\neight\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\npresented\tO\nwith\tO\ncomplete\tO\nheart\tB-Disease\nblock\tI-Disease\nand\tO\nrefractory\tO\nhypotension\tB-Disease\ntwo\tO\ndays\tO\nafter\tO\na\tO\ntherapeutic\tO\ndose\tO\nof\tO\nsustained\tO\n-\tO\nrelease\tO\nverapamil\tB-Chemical\nwith\tO\nconcomitant\tO\nuse\tO\nof\tO\nmetoprolol\tB-Chemical\n.\tO\n\nThe\tO\npatient\tO\ncontinued\tO\nto\tO\nremain\tO\nhypotensive\tB-Disease\nwith\tO\ncomplete\tO\nheart\tB-Disease\nblock\tI-Disease\n,\tO\neven\tO\nwith\tO\nmultiple\tO\nuses\tO\nof\tO\nintravenous\tO\natropine\tB-Chemical\nas\tO\nwell\tO\nas\tO\nhigh\tO\ndoses\tO\nof\tO\npressor\tO\nagents\tO\nsuch\tO\nas\tO\ndopamine\tB-Chemical\nand\tO\ndobutamine\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nshortly\tO\nafter\tO\nthe\tO\nuse\tO\nof\tO\nintravenous\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\n,\tO\nthe\tO\nrefractory\tO\nhypotension\tB-Disease\nand\tO\ncomplete\tO\nheart\tB-Disease\nblock\tI-Disease\nresolved\tO\n.\tO\n\nProtective\tO\neffect\tO\nof\tO\nmisoprostol\tB-Chemical\non\tO\nindomethacin\tB-Chemical\ninduced\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\nin\tO\nelderly\tO\npatients\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\npossible\tO\nprotective\tO\neffects\tO\nof\tO\nmisoprostol\tB-Chemical\non\tO\nrenal\tO\nfunction\tO\nin\tO\nhospitalized\tO\nelderly\tO\npatients\tO\ntreated\tO\nwith\tO\nindomethacin\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nForty\tO\n-\tO\nfive\tO\nhospitalized\tO\nelderly\tO\npatients\tO\n(\tO\n>\tO\n65\tO\nyears\tO\nold\tO\n)\tO\nwho\tO\nrequired\tO\ntherapy\tO\nwith\tO\nnonsteroidal\tO\nantiinflammatory\tO\ndrugs\tO\n(\tO\nNSAID\tO\n)\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nreceive\tO\neither\tO\nindomethacin\tB-Chemical\n,\tO\n150\tO\nmg\tO\n/\tO\nday\tO\n(\tO\nGroup\tO\nA\tO\n)\tO\n,\tO\nor\tO\nindomethacin\tB-Chemical\n150\tO\nmg\tO\n/\tO\nday\tO\nplus\tO\nmisoprostol\tB-Chemical\nat\tO\n0\tO\n.\tO\n6\tO\nmg\tO\n/\tO\nday\tO\n(\tO\nGroup\tO\nB\tO\n)\tO\n.\tO\n\nLaboratory\tO\nvariables\tO\nof\tO\nrenal\tO\nfunction\tO\n[\tO\nserum\tO\ncreatinine\tB-Chemical\n,\tO\nblood\tB-Chemical\nurea\tI-Chemical\nnitrogen\tI-Chemical\n(\tO\nBUN\tB-Chemical\n)\tO\nand\tO\nelectrolytes\tO\n]\tO\nwere\tO\nevaluated\tO\nbefore\tO\ninitiation\tO\nof\tO\ntherapy\tO\nand\tO\nevery\tO\n2\tO\ndays\tO\n,\tO\nuntil\tO\ntermination\tO\nof\tO\nthe\tO\nstudy\tO\n(\tO\na\tO\nperiod\tO\nof\tO\nat\tO\nleast\tO\n6\tO\ndays\tO\n)\tO\n.\tO\n\nResponse\tO\nto\tO\ntreatment\tO\nwas\tO\nestimated\tO\nby\tO\nthe\tO\nvisual\tO\nanalog\tO\nscale\tO\nfor\tO\nseverity\tO\nof\tO\npain\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nForty\tO\n-\tO\ntwo\tO\npatients\tO\ncompleted\tO\nthe\tO\nstudy\tO\n,\tO\n22\tO\nin\tO\nGroup\tO\nA\tO\nand\tO\n20\tO\nin\tO\nGroup\tO\nB\tO\n.\tO\n\nBUN\tB-Chemical\nand\tO\ncreatinine\tB-Chemical\nincreased\tO\nby\tO\n>\tO\n50\tO\n%\tO\nof\tO\nbaseline\tO\nlevels\tO\nin\tO\n54\tO\nand\tO\n45\tO\n%\tO\nof\tO\nGroup\tO\nA\tO\npatients\tO\n,\tO\nrespectively\tO\n,\tO\ncompared\tO\nto\tO\nonly\tO\n20\tO\nand\tO\n10\tO\n%\tO\nof\tO\nGroup\tO\nB\tO\npatients\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nPotassium\tB-Chemical\n(\tO\nK\tB-Chemical\n)\tO\nincrement\tO\nof\tO\n0\tO\n.\tO\n6\tO\nmEq\tO\n/\tO\nl\tO\nor\tO\nmore\tO\nwas\tO\nobserved\tO\nin\tO\n50\tO\n%\tO\nof\tO\nGroup\tO\nA\tO\n,\tO\nbut\tO\nin\tO\nonly\tO\n15\tO\n%\tO\nof\tO\nGroup\tO\nB\tO\npatients\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nincrements\tO\nin\tO\nBUN\tB-Chemical\n,\tO\ncreatinine\tB-Chemical\n,\tO\nand\tO\nK\tB-Chemical\nwere\tO\nreduced\tO\nby\tO\n63\tO\n,\tO\n80\tO\n,\tO\nand\tO\n42\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nGroup\tO\nB\tO\npatients\tO\ncompared\tO\nto\tO\nGroup\tO\nA\tO\n.\tO\nResponse\tO\nto\tO\ntreatment\tO\ndid\tO\nnot\tO\ndiffer\tO\nsignificantly\tO\nbetween\tO\nthe\tO\n2\tO\ngroups\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nHospitalized\tO\nelderly\tO\npatients\tO\nare\tO\nat\tO\nrisk\tO\nfor\tO\ndeveloping\tO\nindomethacin\tB-Chemical\nrelated\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nAddition\tO\nof\tO\nmisoprostol\tB-Chemical\ncan\tO\nminimize\tO\nthis\tO\nrenal\tB-Disease\nimpairment\tI-Disease\nwithout\tO\naffecting\tO\npain\tB-Disease\ncontrol\tO\n.\tO\n\nCognitive\tB-Disease\ndeterioration\tI-Disease\nfrom\tO\nlong\tO\n-\tO\nterm\tO\nabuse\tO\nof\tO\ndextromethorphan\tB-Chemical\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nDextromethorphan\tB-Chemical\n(\tO\nDM\tB-Chemical\n)\tO\n,\tO\nthe\tO\ndextrorotatory\tO\nisomer\tO\nof\tO\n3\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\nmethylmorphinan\tI-Chemical\n,\tO\nis\tO\nthe\tO\nmain\tO\ningredient\tO\nin\tO\na\tO\nnumber\tO\nof\tO\nwidely\tO\navailable\tO\n,\tO\nover\tO\n-\tO\nthe\tO\n-\tO\ncounter\tO\nantitussives\tO\n.\tO\n\nInitial\tO\nstudies\tO\n(\tO\nBornstein\tO\n1968\tO\n)\tO\nshowed\tO\nthat\tO\nit\tO\npossessed\tO\nno\tO\nrespiratory\tO\nsuppressant\tO\neffects\tO\nand\tO\nno\tO\naddiction\tO\nliability\tO\n.\tO\n\nSubsequently\tO\n,\tO\nhowever\tO\n,\tO\nseveral\tO\narticles\tO\nreporting\tO\nabuse\tO\nof\tO\nthis\tO\ndrug\tO\nhave\tO\nappeared\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nThe\tO\ndrug\tO\nis\tO\nknown\tO\nto\tO\ncause\tO\na\tO\nvariety\tO\nof\tO\nacute\tO\ntoxic\tO\neffects\tO\n,\tO\nranging\tO\nfrom\tO\nnausea\tB-Disease\n,\tO\nrestlessness\tB-Disease\n,\tO\ninsomnia\tB-Disease\n,\tO\nataxia\tB-Disease\n,\tO\nslurred\tO\nspeech\tO\nand\tO\nnystagmus\tB-Disease\nto\tO\nmood\tO\nchanges\tO\n,\tO\nperceptual\tO\nalterations\tO\n,\tO\ninattention\tO\n,\tO\ndisorientation\tO\nand\tO\naggressive\tB-Disease\nbehavior\tI-Disease\n(\tO\nRammer\tO\net\tO\nal\tO\n1988\tO\n;\tO\nKatona\tO\nand\tO\nWatson\tO\n1986\tO\n;\tO\nIsbell\tO\nand\tO\nFraser\tO\n1953\tO\n;\tO\nDevlin\tO\net\tO\nal\tO\n1985\tO\n;\tO\nMcCarthy\tO\n1971\tO\n;\tO\nDodds\tO\nand\tO\nRevai\tO\n1967\tO\n;\tO\nDegkwitz\tO\n1964\tO\n;\tO\nHildebrand\tO\net\tO\nal\tO\n1989\tO\n)\tO\n.\tO\n\nThere\tO\nhave\tO\nalso\tO\nbeen\tO\ntwo\tO\nreported\tO\nfatalities\tO\nfrom\tO\nDM\tB-Chemical\noverdoses\tO\n(\tO\nFleming\tO\n1986\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nare\tO\nno\tO\nreports\tO\ndescribing\tO\nthe\tO\neffects\tO\nof\tO\nchronic\tO\nabuse\tO\n.\tO\n\nThis\tO\nreport\tO\ndescribes\tO\na\tO\ncase\tO\nof\tO\ncognitive\tB-Disease\ndeterioration\tI-Disease\nresulting\tO\nfrom\tO\nprolonged\tO\nuse\tO\nof\tO\nDM\tB-Chemical\n.\tO\n\nEffects\tO\nof\tO\nouabain\tB-Chemical\non\tO\nmyocardial\tO\noxygen\tB-Chemical\nsupply\tO\nand\tO\ndemand\tO\nin\tO\npatients\tO\nwith\tO\nchronic\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n.\tO\n\nA\tO\nhemodynamic\tO\n,\tO\nvolumetric\tO\n,\tO\nand\tO\nmetabolic\tO\nstudy\tO\nin\tO\npatients\tO\nwithout\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ndigitalis\tB-Chemical\nglycosides\tI-Chemical\non\tO\nmyocardial\tO\noxygen\tB-Chemical\nsupply\tO\nand\tO\ndemand\tO\nare\tO\nof\tO\nparticular\tO\ninterest\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nobstructive\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n,\tO\nbut\tO\nhave\tO\nnot\tO\nbeen\tO\nmeasured\tO\npreviously\tO\nin\tO\nman\tO\n.\tO\n\nWe\tO\nassessed\tO\nthe\tO\neffects\tO\nof\tO\nouabain\tB-Chemical\n(\tO\n0\tO\n.\tO\n015\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n)\tO\non\tO\nhemodynamic\tO\n,\tO\nvolumetric\tO\n,\tO\nand\tO\nmetabolic\tO\nparameters\tO\nin\tO\n11\tO\npatients\tO\nwith\tO\nsevere\tO\nchronic\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nwithout\tO\nclinical\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n.\tO\n\nBecause\tO\nthe\tO\nprotocol\tO\nwas\tO\nlong\tO\nand\tO\ninvolved\tO\ninterventions\tO\nwhich\tO\nmight\tO\naffect\tO\nthe\tO\ndeterminations\tO\n,\tO\nwe\tO\nalso\tO\nstudied\tO\nin\tO\nnine\tO\npatients\tO\nusing\tO\nan\tO\nidentical\tO\nprotocol\tO\nexcept\tO\nthat\tO\nouabain\tB-Chemical\nadministration\tO\nwas\tO\nomitted\tO\n.\tO\n\nLeft\tO\nventricular\tO\nend\tO\n-\tO\ndiastolic\tO\npressure\tO\nand\tO\nleft\tO\nventricular\tO\nend\tO\n-\tO\ndiastolic\tO\nvolume\tO\nfell\tO\nin\tO\neach\tO\npatient\tO\ngiven\tO\nouabain\tB-Chemical\n,\tO\neven\tO\nthough\tO\nthey\tO\nwere\tO\ninitially\tO\nelevated\tO\nin\tO\nonly\tO\ntwo\tO\npatients\tO\n.\tO\n\nLeft\tO\nventricular\tO\nend\tO\n-\tO\ndiastolic\tO\npressure\tO\nfell\tO\nfrom\tO\n11\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n4\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\nto\tO\n5\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n9\tO\nmm\tO\nHg\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\nleft\tO\nventricular\tO\nend\tO\n-\tO\ndiastolic\tO\nvolume\tO\nfell\tO\nfrom\tO\n100\tO\n+\tO\n/\tO\n-\tO\n17\tO\nto\tO\n82\tO\n+\tO\n/\tO\n-\tO\n12\tO\nml\tO\n/\tO\nm2\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n1\tO\nh\tO\nafter\tO\nouabain\tB-Chemical\ninfusion\tO\nwas\tO\ncompleted\tO\n.\tO\n\nThe\tO\nmaximum\tO\nvelocity\tO\nof\tO\ncontractile\tO\nelement\tO\nshortening\tO\nincreased\tO\nfrom\tO\n1\tO\n.\tO\n68\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n11\tO\nml\tO\n/\tO\ns\tO\nto\tO\n2\tO\n.\tO\n18\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n21\tO\nmuscle\tO\n-\tO\nlengths\tO\n/\tO\ns\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nis\tO\nconsistent\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\ncontractility\tO\n.\tO\n\nNo\tO\nsignificant\tO\nchange\tO\nin\tO\nthese\tO\nparameters\tO\noccurred\tO\nin\tO\nthe\tO\ncontrol\tO\npatients\tO\n.\tO\n\nNo\tO\nsignificant\tO\nchange\tO\nin\tO\nmyocardial\tO\noxygen\tB-Chemical\nconsumption\tO\noccurred\tO\nafter\tO\nouabain\tB-Chemical\nadministration\tO\nbut\tO\nthis\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\na\tO\ngreater\tO\ndecrease\tO\nin\tO\nmean\tO\narterial\tO\npressure\tO\nin\tO\nthe\tO\nouabain\tB-Chemical\npatients\tO\nthan\tO\nin\tO\nthe\tO\ncontrol\tO\npatients\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nin\tO\npatients\tO\nwith\tO\nchronic\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nwho\tO\nare\tO\nnot\tO\nin\tO\nclinical\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\nleft\tB-Disease\nventricular\tI-Disease\nend\tI-Disease\n-\tI-Disease\ndiastolic\tI-Disease\nvolume\tI-Disease\nfalls\tI-Disease\nafter\tO\nouabain\tB-Chemical\nadministration\tO\neven\tO\nwhen\tO\nit\tO\nis\tO\ninitially\tO\nnormal\tO\n.\tO\n\nThough\tO\nthis\tO\nfall\tO\nwould\tO\nbe\tO\nassociated\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\nwall\tO\ntension\tO\n,\tO\nand\tO\n,\tO\ntherefore\tO\n,\tO\nof\tO\nmyocardial\tO\noxygen\tB-Chemical\nconsumption\tO\n,\tO\nit\tO\nmay\tO\nnot\tO\nbe\tO\nof\tO\nsufficient\tO\nmagnitude\tO\nto\tO\nprevent\tO\na\tO\nnet\tO\nincrease\tO\nin\tO\nmyocardial\tO\noxygen\tB-Chemical\nconsumption\tO\n.\tO\n\nNevertheless\tO\n,\tO\ncompensatory\tO\nmechanisms\tO\nprevent\tO\na\tO\ndeterioration\tO\nof\tO\nresting\tO\nmyocardial\tO\nmetabolism\tO\n.\tO\n\nDexamethasone\tB-Chemical\n-\tO\ninduced\tO\nocular\tB-Disease\nhypertension\tI-Disease\nin\tO\nperfusion\tO\n-\tO\ncultured\tO\nhuman\tO\neyes\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nGlucocorticoid\tO\nadministration\tO\ncan\tO\nlead\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\nocular\tB-Disease\nhypertension\tI-Disease\nand\tO\ncorticosteroid\tB-Disease\nglaucoma\tI-Disease\nin\tO\na\tO\nsubset\tO\nof\tO\nthe\tO\npopulation\tO\nthrough\tO\na\tO\ndecrease\tO\nin\tO\nthe\tO\naqueous\tO\nhumor\tO\noutflow\tO\nfacility\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nwhether\tO\nglucocorticoid\tO\ntreatment\tO\ncan\tO\ndirectly\tO\naffect\tO\nthe\tO\noutflow\tO\nfacility\tO\nof\tO\nisolated\tO\n,\tO\nperfusion\tO\n-\tO\ncultured\tO\nhuman\tO\neyes\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nanterior\tO\nsegments\tO\nof\tO\nhuman\tO\ndonor\tO\neyes\tO\nfrom\tO\nregional\tO\neye\tO\nbanks\tO\nwere\tO\nplaced\tO\nin\tO\na\tO\nconstant\tO\nflow\tO\n,\tO\nvariable\tO\npressure\tO\nperfusion\tO\nculture\tO\nsystem\tO\n.\tO\n\nPaired\tO\neyes\tO\nwere\tO\nperfused\tO\nin\tO\nserum\tO\n-\tO\nfree\tO\nmedia\tO\nwith\tO\nor\tO\nwithout\tO\n10\tO\n(\tO\n-\tO\n7\tO\n)\tO\nM\tO\ndexamethasone\tB-Chemical\nfor\tO\n12\tO\ndays\tO\n.\tO\n\nIntraocular\tO\npressure\tO\nwas\tO\nmonitored\tO\ndaily\tO\n.\tO\n\nAfter\tO\nincubation\tO\n,\tO\nthe\tO\neyes\tO\nwere\tO\nmorphologically\tO\ncharacterized\tO\nby\tO\nlight\tO\nmicroscopy\tO\n,\tO\ntransmission\tO\nand\tO\nscanning\tO\nelectron\tO\nmicroscopy\tO\n,\tO\nand\tO\nscanning\tO\nlaser\tO\nconfocal\tO\nmicroscopy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\nsignificant\tO\nincrease\tO\nin\tO\nintraocular\tO\npressure\tO\ndeveloped\tO\nin\tO\n13\tO\nof\tO\nthe\tO\n44\tO\npairs\tO\nof\tO\neyes\tO\nperfused\tO\nwith\tO\ndexamethasone\tB-Chemical\nwith\tO\nan\tO\naverage\tO\npressure\tO\nrise\tO\nof\tO\n17\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n8\tO\nmm\tO\nHg\tO\nafter\tO\n12\tO\ndays\tO\nof\tO\ndexamethasone\tB-Chemical\nexposure\tO\n.\tO\n\nThe\tO\ncontralateral\tO\ncontrol\tO\neyes\tO\n,\tO\nwhich\tO\ndid\tO\nnot\tO\nreceive\tO\ndexamethasone\tB-Chemical\n,\tO\nmaintained\tO\na\tO\nstable\tO\nintraocular\tO\npressure\tO\nduring\tO\nthe\tO\nsame\tO\nperiod\tO\n.\tO\n\nThe\tO\noutflow\tO\npathway\tO\nof\tO\nthe\tO\nuntreated\tO\neyes\tO\nappeared\tO\nmorphologically\tO\nnormal\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthe\tO\ndexamethasone\tB-Chemical\n-\tO\ntreated\tO\nhypertensive\tB-Disease\neyes\tI-Disease\nhad\tO\nthickened\tO\ntrabecular\tO\nbeams\tO\n,\tO\ndecreased\tO\nintertrabecular\tO\nspaces\tO\n,\tO\nthickened\tO\njuxtacanalicular\tO\ntissue\tO\n,\tO\nactivated\tO\ntrabecular\tO\nmeshwork\tO\ncells\tO\n,\tO\nand\tO\nincreased\tO\namounts\tO\nof\tO\namorphogranular\tO\nextracellular\tO\nmaterial\tO\n,\tO\nespecially\tO\nin\tO\nthe\tO\njuxtacanalicular\tO\ntissue\tO\nand\tO\nbeneath\tO\nthe\tO\nendothelial\tO\nlining\tO\nof\tO\nthe\tO\ncanal\tO\nof\tO\nSchlemm\tO\n.\tO\n\nThe\tO\ndexamethasone\tB-Chemical\n-\tO\ntreated\tO\nnonresponder\tO\neyes\tO\nappeared\tO\nto\tO\nbe\tO\nmorphologically\tO\nsimilar\tO\nto\tO\nthe\tO\nuntreated\tO\neyes\tO\n,\tO\nalthough\tO\nseveral\tO\nsubtle\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nmorphologic\tO\nchanges\tO\nwere\tO\nevident\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nDexamethasone\tB-Chemical\ntreatment\tO\nof\tO\nisolated\tO\n,\tO\nperfusion\tO\n-\tO\ncultured\tO\nhuman\tO\neyes\tO\nled\tO\nto\tO\nthe\tO\ngeneration\tO\nof\tO\nocular\tB-Disease\nhypertension\tI-Disease\nin\tO\napproximately\tO\n30\tO\n%\tO\nof\tO\nthe\tO\ndexamethasone\tB-Chemical\n-\tO\ntreated\tO\neyes\tO\n.\tO\n\nSteroid\tB-Chemical\ntreatment\tO\nresulted\tO\nin\tO\nmorphologic\tO\nchanges\tO\nin\tO\nthe\tO\ntrabecular\tO\nmeshwork\tO\nsimilar\tO\nto\tO\nthose\tO\nreported\tO\nfor\tO\ncorticosteroid\tB-Disease\nglaucoma\tI-Disease\nand\tO\nopen\tB-Disease\nangle\tI-Disease\nglaucoma\tI-Disease\n.\tO\n\nThis\tO\nsystem\tO\nmay\tO\nprovide\tO\nan\tO\nacute\tO\nmodel\tO\nin\tO\nwhich\tO\nto\tO\nstudy\tO\nthe\tO\npathogenic\tO\nmechanisms\tO\ninvolved\tO\nin\tO\nsteroid\tB-Disease\nglaucoma\tI-Disease\nand\tO\nprimary\tB-Disease\nopen\tI-Disease\nangle\tI-Disease\nglaucoma\tI-Disease\n.\tO\n\nAuditory\tO\ndisturbance\tO\nassociated\tO\nwith\tO\ninterscalene\tO\nbrachial\tO\nplexus\tO\nblock\tO\n.\tO\n\nWe\tO\nperformed\tO\nan\tO\naudiometric\tO\nstudy\tO\nin\tO\n20\tO\npatients\tO\nwho\tO\nunderwent\tO\nsurgery\tO\nof\tO\nthe\tO\nshoulder\tO\nregion\tO\nunder\tO\nan\tO\ninterscalene\tO\nbrachial\tO\nplexus\tO\nblock\tO\n(\tO\nIBPB\tO\n)\tO\n.\tO\n\nBupivacaine\tB-Chemical\n0\tO\n.\tO\n75\tO\n%\tO\nwith\tO\nadrenaline\tB-Chemical\nwas\tO\ngiven\tO\nfollowed\tO\nby\tO\na\tO\n24\tO\n-\tO\nhr\tO\ncontinuous\tO\ninfusion\tO\nof\tO\n0\tO\n.\tO\n25\tO\n%\tO\nbupivacaine\tB-Chemical\n.\tO\n\nThree\tO\naudiometric\tO\nthreshold\tO\nmeasurements\tO\n(\tO\n0\tO\n.\tO\n25\tO\n-\tO\n18\tO\nkHz\tO\n)\tO\nwere\tO\nmade\tO\n:\tO\nthe\tO\nfirst\tO\nbefore\tO\nIBPB\tO\n,\tO\nthe\tO\nsecond\tO\n2\tO\n-\tO\n6\tO\nh\tO\nafter\tO\nsurgery\tO\nand\tO\nthe\tO\nthird\tO\non\tO\nthe\tO\nfirst\tO\nday\tO\nafter\tO\noperation\tO\n.\tO\n\nIn\tO\nfour\tO\npatients\tO\nhearing\tB-Disease\nimpairment\tI-Disease\non\tO\nthe\tO\nside\tO\nof\tO\nthe\tO\nblock\tO\nwas\tO\ndemonstrated\tO\nafter\tO\noperation\tO\n,\tO\nin\tO\nthree\tO\nmeasurements\tO\non\tO\nthe\tO\nday\tO\nof\tO\nsurgery\tO\nand\tO\nin\tO\none\tO\non\tO\nthe\tO\nfollowing\tO\nday\tO\n.\tO\n\nThe\tO\nfrequencies\tO\nat\tO\nwhich\tO\nthe\tO\nimpairment\tO\noccurred\tO\nvaried\tO\nbetween\tO\npatients\tO\n;\tO\nin\tO\none\tO\nonly\tO\nlow\tO\nfrequencies\tO\n(\tO\n0\tO\n.\tO\n25\tO\n-\tO\n0\tO\n.\tO\n5\tO\nkHz\tO\n)\tO\nwere\tO\ninvolved\tO\n.\tO\n\nThe\tO\nmaximum\tO\nchange\tO\nin\tO\nthreshold\tO\nwas\tO\n35\tO\ndB\tO\nat\tO\n6\tO\nkHz\tO\nmeasured\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\ncontinuous\tO\ninfusion\tO\nof\tO\nbupivacaine\tB-Chemical\n.\tO\n\nThis\tO\npatient\tO\nhad\tO\nhearing\tO\nthreshold\tO\nchanges\tO\n(\tO\n15\tO\n-\tO\n20\tO\ndB\tO\n)\tO\nat\tO\n6\tO\n-\tO\n10\tO\nkHz\tO\non\tO\nthe\tO\nopposite\tO\nside\tO\nalso\tO\n.\tO\n\nIBPB\tO\nmay\tO\ncause\tO\ntransient\tO\nauditory\tB-Disease\ndysfunction\tI-Disease\nin\tO\nthe\tO\nipsilateral\tO\near\tO\n,\tO\npossibly\tO\nvia\tO\nan\tO\neffect\tO\non\tO\nsympathetic\tO\ninnervation\tO\n.\tO\n\nThe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\ncombination\tO\nN\tB-Chemical\n-\tI-Chemical\nbutyl\tI-Chemical\n-\tI-Chemical\ndeoxynojirimycin\tI-Chemical\n(\tO\nSC\tB-Chemical\n-\tI-Chemical\n48334\tI-Chemical\n)\tO\nand\tO\nzidovudine\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nHIV\tB-Disease\n-\tI-Disease\n1\tI-Disease\ninfection\tI-Disease\nand\tO\n200\tO\n-\tO\n500\tO\nCD4\tO\ncells\tO\n/\tO\nmm3\tO\n.\tO\n\nWe\tO\nconducted\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nrandomized\tO\nphase\tO\nII\tO\nstudy\tO\nto\tO\nevaluate\tO\nthe\tO\nsafety\tO\nand\tO\nactivity\tO\nof\tO\ncombination\tO\ntherapy\tO\nwith\tO\nN\tB-Chemical\n-\tI-Chemical\nbutyl\tI-Chemical\n-\tI-Chemical\ndeoxynojirimycin\tI-Chemical\n(\tO\nSC\tB-Chemical\n-\tI-Chemical\n48334\tI-Chemical\n)\tO\n(\tO\nan\tO\nalpha\tO\n-\tO\nglucosidase\tO\nI\tO\ninhibitor\tO\n)\tO\nand\tO\nzidovudine\tB-Chemical\nversus\tO\nzidovudine\tB-Chemical\nalone\tO\n.\tO\n\nPatients\tO\nwith\tO\n200\tO\nto\tO\n500\tO\nCD4\tO\ncells\tO\n/\tO\nmm3\tO\nwho\tO\ntolerated\tO\n<\tO\nor\tO\n=\tO\n12\tO\nweeks\tO\nof\tO\nprior\tO\nzidovudine\tB-Chemical\ntherapy\tO\nreceived\tO\nSC\tB-Chemical\n-\tI-Chemical\n48334\tI-Chemical\n(\tO\n1000\tO\nmg\tO\nevery\tO\n8\tO\nh\tO\n)\tO\nand\tO\nzidovudine\tB-Chemical\n(\tO\n100\tO\nmg\tO\nevery\tO\n8\tO\nh\tO\n)\tO\nor\tO\nzidovudine\tB-Chemical\nand\tO\nplacebo\tO\n.\tO\n\nSixty\tO\npatients\tO\nreceived\tO\ncombination\tO\ntherapy\tO\nand\tO\n58\tO\n,\tO\nzidovudine\tB-Chemical\nand\tO\nplacebo\tO\n.\tO\n\nTwenty\tO\n-\tO\nthree\tO\npatients\tO\n(\tO\n38\tO\n%\tO\n)\tO\nand\tO\n15\tO\n(\tO\n26\tO\n%\tO\n)\tO\n,\tO\nin\tO\nthe\tO\ncombination\tO\nand\tO\nzidovudine\tB-Chemical\ngroups\tO\n,\tO\nrespectively\tO\n,\tO\ndiscontinued\tO\ntherapy\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n15\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nSC\tB-Chemical\n-\tI-Chemical\n48334\tI-Chemical\nsteady\tO\n-\tO\nstate\tO\ntrough\tO\nlevel\tO\n(\tO\n4\tO\n.\tO\n04\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n99\tO\nmicrograms\tO\n/\tO\nml\tO\n)\tO\nwas\tO\nbelow\tO\nthe\tO\nin\tO\nvitro\tO\ninhibitory\tO\nconcentration\tO\nfor\tO\nhuman\tO\nimmunodeficiency\tB-Disease\nvirus\tO\n(\tO\nHIV\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nincrease\tO\nin\tO\nCD4\tO\ncells\tO\nat\tO\nweek\tO\n4\tO\nwas\tO\n73\tO\n.\tO\n8\tO\ncells\tO\n/\tO\nmm3\tO\nand\tO\n52\tO\n.\tO\n4\tO\ncells\tO\n/\tO\nmm3\tO\nfor\tO\nthe\tO\ncombination\tO\nand\tO\nzidovudine\tB-Chemical\ngroups\tO\n,\tO\nrespectively\tO\n(\tO\np\tO\n>\tO\n0\tO\n.\tO\n36\tO\n)\tO\n.\tO\n\nFor\tO\npatients\tO\nwith\tO\nprior\tO\nzidovudine\tB-Chemical\ntherapy\tO\n,\tO\nthe\tO\nmean\tO\nchange\tO\nin\tO\nCD4\tO\ncells\tO\nin\tO\nthe\tO\ncombination\tO\nand\tO\nzidovudine\tB-Chemical\ngroups\tO\nwas\tO\n63\tO\n.\tO\n7\tO\ncells\tO\n/\tO\nmm3\tO\nand\tO\n4\tO\n.\tO\n9\tO\ncells\tO\n/\tO\nmm3\tO\nat\tO\nweek\tO\n8\tO\nand\tO\n6\tO\n.\tO\n8\tO\ncells\tO\n/\tO\nmm3\tO\nand\tO\n-\tO\n45\tO\n.\tO\n1\tO\ncells\tO\n/\tO\nmm3\tO\nat\tO\nweek\tO\n16\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\npatients\tO\nwith\tO\nsuppression\tO\nof\tO\nHIV\tO\np24\tO\nantigenemia\tO\nin\tO\nthe\tO\ncombination\tO\nand\tO\nzidovudine\tB-Chemical\ngroups\tO\nwas\tO\nsix\tO\n(\tO\n40\tO\n%\tO\n)\tO\nand\tO\ntwo\tO\n(\tO\n11\tO\n%\tO\n)\tO\nat\tO\nweek\tO\n4\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n10\tO\n)\tO\nand\tO\nfive\tO\n(\tO\n45\tO\n%\tO\n)\tO\nand\tO\ntwo\tO\n(\tO\n14\tO\n%\tO\n)\tO\nat\tO\nweek\tO\n24\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n08\tO\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nDiarrhea\tB-Disease\n,\tO\nflatulence\tB-Disease\n,\tO\nabdominal\tB-Disease\npain\tI-Disease\n,\tO\nand\tO\nweight\tB-Disease\nloss\tI-Disease\nwere\tO\ncommon\tO\nfor\tO\ncombination\tO\nrecipients\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nProlonged\tO\nparalysis\tB-Disease\ndue\tO\nto\tO\nnondepolarizing\tB-Chemical\nneuromuscular\tI-Chemical\nblocking\tI-Chemical\nagents\tI-Chemical\nand\tO\ncorticosteroids\tB-Chemical\n.\tO\n\nThe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nnondepolarizing\tB-Chemical\nneuromuscular\tI-Chemical\nblocking\tI-Chemical\nagents\tI-Chemical\n(\tO\nND\tB-Chemical\n-\tI-Chemical\nNMBA\tI-Chemical\n)\tO\nhas\tO\nrecently\tO\nbeen\tO\nimplicated\tO\nas\tO\na\tO\ncause\tO\nof\tO\nprolonged\tO\nmuscle\tB-Disease\nweakness\tI-Disease\n,\tO\nalthough\tO\nthe\tO\nsite\tO\nof\tO\nthe\tO\nlesion\tO\nand\tO\nthe\tO\npredisposing\tO\nfactors\tO\nhave\tO\nbeen\tO\nunclear\tO\n.\tO\n\nWe\tO\nreport\tO\n3\tO\npatients\tO\n(\tO\nage\tO\n37\tO\n-\tO\n52\tO\nyears\tO\n)\tO\nwith\tO\nacute\tO\nrespiratory\tB-Disease\ninsufficiency\tI-Disease\nwho\tO\ndeveloped\tO\nprolonged\tO\nweakness\tB-Disease\nfollowing\tO\nthe\tO\ndiscontinuation\tO\nof\tO\nND\tB-Chemical\n-\tI-Chemical\nNMBAs\tI-Chemical\n.\tO\n\nTwo\tO\npatients\tO\nalso\tO\nreceived\tO\nintravenous\tO\ncorticosteroids\tB-Chemical\n.\tO\n\nRenal\tO\nfunction\tO\nwas\tO\nnormal\tO\nbut\tO\nhepatic\tO\nfunction\tO\nwas\tO\nimpaired\tO\nin\tO\nall\tO\npatients\tO\n,\tO\nand\tO\nall\tO\nhad\tO\nacidosis\tB-Disease\n.\tO\n\nElectrophysiologic\tO\nstudies\tO\nrevealed\tO\nlow\tO\namplitude\tO\ncompound\tO\nmotor\tO\naction\tO\npotentials\tO\n,\tO\nnormal\tO\nsensory\tO\nstudies\tO\n,\tO\nand\tO\nfibrillations\tO\n.\tO\n\nRepetitive\tO\nstimulation\tO\nat\tO\n2\tO\nHz\tO\nshowed\tO\na\tO\ndecremental\tO\nresponse\tO\nin\tO\n2\tO\npatients\tO\n.\tO\n\nThe\tO\nserum\tO\nvecuronium\tB-Chemical\nlevel\tO\nmeasured\tO\nin\tO\n1\tO\npatient\tO\n14\tO\ndays\tO\nafter\tO\nthe\tO\ndrug\tO\nhad\tO\nbeen\tO\ndiscontinued\tO\nwas\tO\n172\tO\nng\tO\n/\tO\nmL\tO\n.\tO\n\nA\tO\nmuscle\tO\nbiopsy\tO\nin\tO\nthis\tO\npatient\tO\nshowed\tO\nloss\tB-Disease\nof\tI-Disease\nthick\tI-Disease\n,\tI-Disease\nmyosin\tI-Disease\nfilaments\tI-Disease\n.\tO\n\nThe\tO\nweakness\tB-Disease\nin\tO\nthese\tO\npatients\tO\nis\tO\ndue\tO\nto\tO\npathology\tB-Disease\nat\tI-Disease\nboth\tI-Disease\nthe\tI-Disease\nneuromuscular\tI-Disease\njunction\tI-Disease\n(\tO\nmost\tO\nlikely\tO\ndue\tO\nto\tO\nND\tB-Chemical\n-\tI-Chemical\nNMBA\tI-Chemical\n)\tO\nand\tO\nmuscle\tO\n(\tO\nmost\tO\nlikely\tO\ndue\tO\nto\tO\ncorticosteroids\tB-Chemical\n)\tO\n.\tO\n\nHepatic\tB-Disease\ndysfunction\tI-Disease\nand\tO\nacidosis\tB-Disease\nare\tO\ncontributing\tO\nrisk\tO\nfactors\tO\n.\tO\n\nFailure\tO\nof\tO\nancrod\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\narterial\tO\nthrombosis\tB-Disease\n.\tO\n\nThe\tO\nmorbidity\tO\nand\tO\nmortality\tO\nassociated\tO\nwith\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombosis\tB-Disease\nremain\tO\nhigh\tO\ndespite\tO\nnumerous\tO\nempirical\tO\ntherapies\tO\n.\tO\n\nAncrod\tO\nhas\tO\nbeen\tO\nused\tO\nsuccessfully\tO\nfor\tO\nprophylaxis\tO\nagainst\tO\ndevelopment\tO\nof\tO\nthrombosis\tB-Disease\nin\tO\npatients\tO\nwith\tO\nheparin\tB-Chemical\ninduced\tO\nplatelet\tB-Disease\naggregation\tI-Disease\nwho\tO\nrequire\tO\nbrief\tO\nreexposure\tO\nto\tO\nheparin\tB-Chemical\n,\tO\nbut\tO\nits\tO\nsuccess\tO\nin\tO\npatients\tO\nwho\tO\nhave\tO\ndeveloped\tO\nthe\tO\nthrombosis\tB-Disease\nsyndrome\tO\nis\tO\nnot\tO\nwell\tO\ndefined\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\ncase\tO\nof\tO\nfailure\tO\nof\tO\nancrod\tO\ntreatment\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombosis\tB-Disease\n.\tO\n\nWater\tB-Disease\nintoxication\tI-Disease\nassociated\tO\nwith\tO\noxytocin\tB-Chemical\nadministration\tO\nduring\tO\nsaline\tO\n-\tO\ninduced\tO\nabortion\tB-Disease\n.\tO\n\nFour\tO\ncases\tO\nof\tO\nwater\tB-Disease\nintoxication\tI-Disease\nin\tO\nconnection\tO\nwith\tO\noxytocin\tB-Chemical\nadministration\tO\nduring\tO\nsaline\tO\n-\tO\ninduced\tO\nabortions\tB-Disease\nare\tO\ndescribed\tO\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\nwater\tB-Disease\nintoxication\tI-Disease\nis\tO\ndiscussed\tO\nin\tO\nregard\tO\nto\tO\nthese\tO\ncases\tO\n.\tO\n\nOxytocin\tB-Chemical\nadministration\tO\nduring\tO\nmidtrimester\tO\n-\tO\ninduced\tO\nabortions\tB-Disease\nis\tO\nadvocated\tO\nonly\tO\nif\tO\nit\tO\ncan\tO\nbe\tO\ncarried\tO\nout\tO\nunder\tO\ncareful\tO\nobservations\tO\nof\tO\nan\tO\nalert\tO\nnursing\tO\nstaff\tO\n,\tO\naware\tO\nof\tO\nthe\tO\nsymptoms\tO\nof\tO\nwater\tB-Disease\nintoxication\tI-Disease\nand\tO\ninstructed\tO\nto\tO\nwatch\tO\nthe\tO\ndiuresis\tO\nand\tO\nreport\tO\nsuch\tO\nearly\tO\nsigns\tO\nof\tO\nthe\tO\nsyndrome\tO\nas\tO\nasthenia\tB-Disease\n,\tO\nmuscular\tO\nirritability\tB-Disease\n,\tO\nor\tO\nheadaches\tB-Disease\n.\tO\n\nThe\tO\noxytocin\tB-Chemical\nshould\tO\nbe\tO\ngiven\tO\nonly\tO\nin\tO\nRingers\tO\nlactate\tB-Chemical\nor\tO\n,\tO\nalternately\tO\n,\tO\nin\tO\nRingers\tO\nlactate\tB-Chemical\nand\tO\na\tO\n5\tO\nper\tO\ncent\tO\ndextrose\tB-Chemical\nand\tO\nwater\tO\nsolutions\tO\n.\tO\n\nThe\tO\nurinary\tO\noutput\tO\nshould\tO\nbe\tO\nmonitored\tO\nand\tO\nthe\tO\noxytocin\tB-Chemical\nadministration\tO\ndiscontinued\tO\nand\tO\nthe\tO\nserum\tO\nelectrolytes\tO\nchecked\tO\nif\tO\nthe\tO\nurinary\tO\noutput\tO\ndecreases\tO\n.\tO\n\nThe\tO\noxytocin\tB-Chemical\nshould\tO\nnot\tO\nbe\tO\nadministered\tO\nin\tO\nexcess\tO\nof\tO\n36\tO\nhours\tO\n.\tO\n\nIf\tO\nthe\tO\npatient\tO\nhas\tO\nnot\tO\naborted\tO\nby\tO\nthen\tO\nthe\tO\noxytocin\tB-Chemical\nshould\tO\nbe\tO\ndiscontinued\tO\nfor\tO\n10\tO\nto\tO\n12\tO\nhours\tO\nin\tO\norder\tO\nto\tO\nperform\tO\nelectrolyte\tO\ndeterminations\tO\nand\tO\ncorrect\tO\nany\tO\nelectrolyte\tO\nimbalance\tO\n.\tO\n\nLight\tO\nchain\tO\nproteinuria\tB-Disease\nand\tO\ncellular\tO\nmediated\tO\nimmunity\tO\nin\tO\nrifampin\tB-Chemical\ntreated\tO\npatients\tO\nwith\tO\ntuberculosis\tB-Disease\n.\tO\n\nLight\tO\nchain\tO\nproteinuria\tB-Disease\nwas\tO\nfound\tO\nin\tO\n9\tO\nof\tO\n17\tO\ntuberculosis\tB-Disease\npatients\tO\ntreated\tO\nwith\tO\nrifampin\tB-Chemical\n.\tO\n\nConcomitant\tO\nassay\tO\nof\tO\ncellular\tO\nmediated\tO\nimmunity\tO\nin\tO\nthese\tO\npatients\tO\nusing\tO\nskin\tO\ntest\tO\nantigen\tO\nand\tO\na\tO\nlymphokine\tO\nin\tO\nvitro\tO\ntest\tO\nprovided\tO\nresults\tO\nthat\tO\nwere\tO\ndifferent\tO\n.\tO\n\nResponse\tO\nto\tO\nVaridase\tO\nskin\tO\ntest\tO\nantigen\tO\nwas\tO\nnegative\tO\nfor\tO\nall\tO\neight\tO\ntuberculosis\tB-Disease\npatients\tO\ntested\tO\n,\tO\nbut\tO\nthere\tO\noccurred\tO\na\tO\nhyper\tO\n-\tO\nresponsiveness\tO\nof\tO\nthe\tO\nlymphocytes\tO\nof\tO\nthese\tO\neight\tO\npatients\tO\nto\tO\nphytomitogen\tO\n(\tO\nPHA\tO\n-\tO\nP\tO\n)\tO\n.\tO\nas\tO\nwell\tO\nas\tO\nof\tO\nthose\tO\nof\tO\nseven\tO\nother\tO\ntuberculous\tB-Disease\npatients\tO\n.\tO\n\nThis\tO\nlast\tO\nfinding\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\ntime\tO\nof\tO\ntesting\tO\nand\tO\n/\tO\nor\tO\nendogenous\tO\nserum\tO\nbinding\tO\nof\tO\nrifampin\tB-Chemical\nwhich\tO\ncould\tO\nhave\tO\ninhibited\tO\nmitogen\tO\nactivity\tO\nfor\tO\nthe\tO\nlymphocyte\tO\n.\tO\n\nKF17837\tB-Chemical\n:\tO\na\tO\nnovel\tO\nselective\tO\nadenosine\tB-Chemical\nA2A\tO\nreceptor\tO\nantagonist\tO\nwith\tO\nanticataleptic\tO\nactivity\tO\n.\tO\n\nKF17837\tB-Chemical\nis\tO\na\tO\nnovel\tO\nselective\tO\nadenosine\tB-Chemical\nA2A\tO\nreceptor\tO\nantagonist\tO\n.\tO\n\nOral\tO\nadministration\tO\nof\tO\nKF17837\tB-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\n,\tO\n10\tO\n.\tO\n0\tO\nand\tO\n30\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nsignificantly\tO\nameliorated\tO\nthe\tO\ncataleptic\tB-Disease\nresponses\tO\ninduced\tO\nby\tO\nintracerebroventricular\tO\nadministration\tO\nof\tO\nan\tO\nadenosine\tB-Chemical\nA2A\tO\nreceptor\tO\nagonist\tO\n,\tO\nCGS\tB-Chemical\n21680\tI-Chemical\n(\tO\n10\tO\nmicrograms\tO\n)\tO\n,\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nKF17837\tB-Chemical\nalso\tO\nreduced\tO\nthe\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nand\tO\nby\tO\nreserpine\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nThese\tO\nanticataleptic\tO\neffects\tO\nwere\tO\nexhibited\tO\ndose\tO\ndependently\tO\nat\tO\ndoses\tO\nfrom\tO\n0\tO\n.\tO\n625\tO\nand\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\n,\tO\nrespectively\tO\n.\tO\n\nMoreover\tO\n,\tO\nKF17837\tB-Chemical\n(\tO\n0\tO\n.\tO\n625\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\npotentiated\tO\nthe\tO\nanticataleptic\tO\neffects\tO\nof\tO\na\tO\nsubthreshold\tO\ndose\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndihydroxyphenylalanine\tI-Chemical\n(\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n;\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nplus\tO\nbenserazide\tB-Chemical\n(\tO\n6\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggested\tO\nthat\tO\nKF17837\tB-Chemical\nis\tO\na\tO\ncentrally\tO\nactive\tO\nadenosine\tB-Chemical\nA2A\tO\nreceptor\tO\nantagonist\tO\nand\tO\nthat\tO\nthe\tO\ndopaminergic\tO\nfunction\tO\nof\tO\nthe\tO\nnigrostriatal\tO\npathway\tO\nis\tO\npotentiated\tO\nby\tO\nadenosine\tB-Chemical\nA2A\tO\nreceptor\tO\nantagonists\tO\n.\tO\n\nFurthermore\tO\n,\tO\nKF17837\tB-Chemical\nmay\tO\nbe\tO\na\tO\nuseful\tO\ndrug\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nparkinsonism\tB-Disease\n.\tO\n\nEffect\tO\nof\tO\nnondopaminergic\tO\ndrugs\tO\non\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nin\tO\nMPTP\tB-Chemical\n-\tO\ntreated\tO\nmonkeys\tO\n.\tO\n\nA\tO\ngroup\tO\nof\tO\nfour\tO\nmonkeys\tO\nwas\tO\nrendered\tO\nparkinsonian\tB-Disease\nwith\tO\nthe\tO\ntoxin\tO\nMPTP\tB-Chemical\n.\tO\n\nThey\tO\nwere\tO\nthen\tO\ntreated\tO\nchronically\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n/\tI-Chemical\nbenserazide\tI-Chemical\n50\tO\n/\tO\n12\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ngiven\tO\norally\tO\ndaily\tO\nfor\tO\n2\tO\nmonths\tO\n.\tO\n\nThis\tO\ndose\tO\nproduced\tO\na\tO\nstriking\tO\nantiparkinsonian\tO\neffect\tO\n,\tO\nbut\tO\nall\tO\nanimals\tO\nmanifested\tO\ndyskinesia\tB-Disease\n.\tO\n\nA\tO\nseries\tO\nof\tO\nagents\tO\nacting\tO\nprimarily\tO\non\tO\nneurotransmitters\tO\nother\tO\nthan\tO\ndopamine\tB-Chemical\nwere\tO\nthen\tO\ntested\tO\nin\tO\ncombination\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\nto\tO\nsee\tO\nif\tO\nthe\tO\ndyskinetic\tB-Disease\nmovements\tO\nwould\tO\nbe\tO\nmodified\tO\n.\tO\n\nSeveral\tO\ndrugs\tO\n,\tO\nincluding\tO\nclonidine\tB-Chemical\n,\tO\nphysostigmine\tB-Chemical\n,\tO\nmethysergide\tB-Chemical\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nMDOT\tI-Chemical\n,\tO\npropranolol\tB-Chemical\n,\tO\nand\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n,\tO\nmarkedly\tO\nreduced\tO\nthe\tO\ndyskinetic\tB-Disease\nmovements\tO\nbut\tO\nat\tO\nthe\tO\ncost\tO\nof\tO\na\tO\nreturn\tO\nof\tO\nparkinsonian\tB-Disease\nsymptomatology\tO\n.\tO\n\nHowever\tO\n,\tO\nyohimbine\tB-Chemical\nand\tO\nmeperidine\tB-Chemical\nreduced\tO\npredominantly\tO\nthe\tO\ndyskinetic\tB-Disease\nmovements\tO\n.\tO\n\nBaclofen\tB-Chemical\nwas\tO\nalso\tO\nuseful\tO\nin\tO\none\tO\nmonkey\tO\nagainst\tO\na\tO\nmore\tO\ndystonic\tB-Disease\nform\tO\nof\tO\ndyskinesia\tB-Disease\n.\tO\n\nAtropine\tB-Chemical\nconverted\tO\nthe\tO\ndystonic\tB-Disease\nmovements\tO\ninto\tO\nchorea\tB-Disease\n.\tO\n\nHallucinations\tB-Disease\nand\tO\nifosfamide\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nHallucinations\tB-Disease\nas\tO\na\tO\nsymptom\tO\nof\tO\ncentral\tO\nneurotoxicity\tB-Disease\nare\tO\na\tO\nknown\tO\nbut\tO\npoorly\tO\ndescribed\tO\nside\tO\neffect\tO\nof\tO\nifosfamide\tB-Chemical\n.\tO\n\nMost\tO\ncases\tO\nof\tO\nifosfamide\tB-Chemical\n-\tO\ninduced\tO\nhallucinations\tB-Disease\nhave\tO\nbeen\tO\nreported\tO\nwith\tO\nother\tO\nmental\tO\nstatus\tO\nchanges\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nauthors\tO\ninterviewed\tO\nsix\tO\npersons\tO\nwith\tO\nifosfamide\tB-Chemical\n-\tO\ninduced\tO\nhallucinations\tB-Disease\nin\tO\nthe\tO\npresence\tO\nof\tO\na\tO\nclear\tO\nsensorium\tO\n.\tO\n\nAll\tO\npatients\tO\nwere\tO\nreceiving\tO\nhigh\tO\n-\tO\ndose\tO\nifosfamide\tB-Chemical\nas\tO\npart\tO\nof\tO\ntheir\tO\nbone\tO\nmarrow\tO\ntransplant\tO\nprocedure\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHallucinations\tB-Disease\noccurred\tO\nonly\tO\nwhen\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\neyes\tO\nwere\tO\nclosed\tO\nand\tO\n,\tO\nin\tO\nall\tO\nbut\tO\none\tO\ncase\tO\n,\tO\nwere\tO\nreported\tO\nas\tO\ndisturbing\tO\nor\tO\nfrightening\tO\n.\tO\n\nUnderreporting\tO\nof\tO\nthese\tO\nhallucinations\tB-Disease\nby\tO\npatients\tO\nis\tO\nlikely\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nHallucinations\tB-Disease\nmay\tO\nbe\tO\nthe\tO\nsole\tO\nor\tO\nfirst\tO\nmanifestation\tO\nof\tO\nneurotoxicity\tB-Disease\n.\tO\n\nThe\tO\nincidence\tO\nmay\tO\nbe\tO\ndose\tO\nand\tO\ninfusion\tO\n-\tO\ntime\tO\nrelated\tO\n.\tO\n\nThe\tO\nclinician\tO\nshould\tO\nbe\tO\nalerted\tO\nfor\tO\npossible\tO\nifosfamide\tB-Chemical\n-\tO\ninduced\tO\nhallucinations\tB-Disease\n,\tO\nwhich\tO\nmay\tO\noccur\tO\nwithout\tO\nother\tO\nsigns\tO\nof\tO\nneurotoxicity\tB-Disease\n.\tO\n\n\"\tO\nEyes\tO\n-\tO\nclosed\tO\n\"\tO\nhallucinatory\tB-Disease\nexperiences\tO\nappear\tO\nto\tO\nbe\tO\nan\tO\nunusual\tO\nfeature\tO\nof\tO\nthis\tO\npresentation\tO\n.\tO\n\nPatients\tO\nanxious\tO\nabout\tO\nthis\tO\nexperience\tO\nrespond\tO\nwell\tO\nto\tO\nsupport\tO\nand\tO\neducation\tO\nabout\tO\nthis\tO\noccurrence\tO\n.\tO\n\nOptimal\tO\npharmacologic\tO\nmanagement\tO\nof\tO\ndisturbed\tO\npatients\tO\nis\tO\nunclear\tO\n.\tO\n\nIf\tO\nagitation\tB-Disease\nbecomes\tO\nmarked\tO\n,\tO\nhigh\tO\n-\tO\npotency\tO\nneuroleptics\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nhaloperidol\tB-Chemical\n)\tO\nmay\tO\nbe\tO\neffective\tO\n.\tO\n\nPhotodistributed\tO\nnifedipine\tB-Chemical\n-\tO\ninduced\tO\nfacial\tO\ntelangiectasia\tB-Disease\n.\tO\n\nFive\tO\nmonths\tO\nafter\tO\nstarting\tO\nnifedipine\tB-Chemical\n(\tO\nAdalat\tB-Chemical\n)\tO\n,\tO\ntwo\tO\npatients\tO\ndeveloped\tO\nphotodistributed\tO\nfacial\tO\ntelangiectasia\tB-Disease\n,\tO\nwhich\tO\nbecame\tO\nmore\tO\nnoticeable\tO\nwith\tO\ntime\tO\n.\tO\n\nNeither\tO\npatient\tO\ncomplained\tO\nof\tO\nphotosensitivity\tO\nor\tO\nflushing\tB-Disease\n.\tO\n\nBoth\tO\npatients\tO\nreported\tO\na\tO\nsignificant\tO\ncosmetic\tO\nimprovement\tO\nafter\tO\ndiscontinuing\tO\nthe\tO\ndrug\tO\n.\tO\n\nOne\tO\ncommenced\tO\nthe\tO\nclosely\tO\nrelated\tO\ndrug\tO\namlodipine\tB-Chemical\n3\tO\nyears\tO\nlater\tO\n,\tO\nwith\tO\nrecurrence\tO\nof\tO\ntelangiectasia\tB-Disease\n.\tO\n\nThe\tO\nphotodistribution\tO\nof\tO\nthe\tO\ntelangiectasia\tB-Disease\nsuggests\tO\na\tO\nsignificant\tO\ndrug\tO\n/\tO\nlight\tO\ninteraction\tO\n.\tO\n\nPenicillamine\tB-Chemical\n-\tO\ninduced\tO\nrapidly\tO\nprogressive\tO\nglomerulonephritis\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nA\tO\n67\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\npresented\tO\nrapidly\tO\nprogressive\tO\nglomerulonephritis\tB-Disease\n(\tO\nRPGN\tB-Disease\n)\tO\nafter\tO\n5\tO\nmonths\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n(\tO\n250\tO\nmg\tO\n/\tO\nday\tO\n)\tO\ntreatment\tO\n.\tO\n\nLight\tO\nmicroscopy\tO\nstudy\tO\nshowed\tO\nsevere\tO\nglomerulonephritis\tB-Disease\nwith\tO\ncrescent\tO\nformation\tO\nin\tO\n60\tO\n%\tO\nof\tO\nthe\tO\nglomeruli\tO\nand\tO\ninfiltration\tO\nof\tO\ninflammatory\tO\ncells\tO\nin\tO\nthe\tO\nwall\tO\nof\tO\nan\tO\narteriole\tO\n.\tO\n\nImmunofluorescence\tO\nrevealed\tO\nscanty\tO\ngranular\tO\nIgG\tO\n,\tO\nIgA\tO\nand\tO\nC3\tO\ndeposits\tO\nalong\tO\nthe\tO\ncapillary\tO\nwalls\tO\nand\tO\nmesangium\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\ntreated\tO\nwith\tO\nsteroid\tB-Chemical\npulse\tO\n,\tO\nplasmapheresis\tO\n,\tO\ncyclophosphamide\tB-Chemical\nand\tO\nantiplatelet\tB-Chemical\nagents\tI-Chemical\n.\tO\n\nA\tO\ncomplete\tO\nrecovery\tO\nof\tO\nrenal\tO\nfunction\tO\nwas\tO\nachieved\tO\nin\tO\na\tO\nfew\tO\nweeks\tO\n.\tO\n\nThis\tO\nnew\tO\ncase\tO\nof\tO\nRPGN\tB-Disease\nin\tO\nthe\tO\ncourse\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\ntreatment\tO\nemphasizes\tO\nthe\tO\nneed\tO\nfor\tO\nfrequent\tO\nmonitoring\tO\nof\tO\nrenal\tO\nfunction\tO\nand\tO\nevaluation\tO\nof\tO\nurinary\tO\nsediment\tO\nand\tO\nproteinuria\tB-Disease\nin\tO\nthese\tO\npatients\tO\n.\tO\n\nThe\tO\nprompt\tO\ndiscontinuation\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\nand\tO\nvigorous\tO\ntreatment\tO\nmeasures\tO\ncould\tO\nallow\tO\nfor\tO\na\tO\ngood\tO\nprognosis\tO\nas\tO\nin\tO\nthis\tO\ncase\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\npolymyositis\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nprimary\tB-Disease\nbiliary\tI-Disease\ncirrhosis\tI-Disease\ntreated\tO\nwith\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n.\tO\n\nAlthough\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\nhas\tO\nbeen\tO\nused\tO\nfor\tO\nmany\tO\nrheumatologic\tB-Disease\ndiseases\tI-Disease\n,\tO\ntoxicity\tB-Disease\nlimits\tO\nits\tO\nusefulness\tO\nin\tO\nmany\tO\npatients\tO\n.\tO\n\nPolymyositis\tB-Disease\n/\tO\ndermatomyositis\tB-Disease\ncan\tO\ndevelop\tO\nas\tO\none\tO\nof\tO\nthe\tO\nautoimmune\tO\ncomplications\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\ntreatment\tO\n,\tO\nbut\tO\nits\tO\nexact\tO\npathogenesis\tO\nremains\tO\nunclear\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\npatient\tO\nwith\tO\nprimary\tB-Disease\nbiliary\tI-Disease\ncirrhosis\tI-Disease\n,\tO\nwho\tO\ndeveloped\tO\npolymyositis\tB-Disease\nwhile\tO\nreceiving\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\ntherapy\tO\n.\tO\n\nWe\tO\ndescribed\tO\nthe\tO\nspecial\tO\nclinical\tO\ncourse\tO\nof\tO\nthe\tO\npatient\tO\n.\tO\n\nPatients\tO\nreceiving\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\ntherapy\tO\nshould\tO\nbe\tO\nfollowed\tO\ncarefully\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nautoimmune\tO\ncomplications\tO\nlike\tO\npolymyositis\tB-Disease\n/\tO\ndermatomyositis\tB-Disease\n.\tO\n\nHyperalgesia\tB-Disease\nand\tO\nmyoclonus\tB-Disease\nin\tO\nterminal\tO\ncancer\tB-Disease\npatients\tO\ntreated\tO\nwith\tO\ncontinuous\tO\nintravenous\tO\nmorphine\tB-Chemical\n.\tO\n\nEight\tO\ncancer\tB-Disease\npatients\tO\nin\tO\nthe\tO\nterminal\tO\nstages\tO\nof\tO\nthe\tO\ndisease\tO\ntreated\tO\nwith\tO\nhigh\tO\ndoses\tO\nof\tO\nintravenous\tO\nmorphine\tB-Chemical\ndeveloped\tO\nhyperalgesia\tB-Disease\n.\tO\n\nAll\tO\ncases\tO\nwere\tO\nretrospectively\tO\nsampled\tO\nfrom\tO\nthree\tO\ndifferent\tO\nhospitals\tO\nin\tO\nCopenhagen\tO\n.\tO\n\nFive\tO\npatients\tO\ndeveloped\tO\nuniversal\tO\nhyperalgesia\tB-Disease\nand\tO\nhyperesthesia\tB-Disease\nwhich\tO\nin\tO\n2\tO\ncases\tO\nwere\tO\naccompanied\tO\nby\tO\nmyoclonus\tB-Disease\n.\tO\n\nIn\tO\n3\tO\npatients\tO\na\tO\npre\tO\n-\tO\nexisting\tO\nneuralgia\tB-Disease\nincreased\tO\nto\tO\nexcruciating\tO\nintensity\tO\nand\tO\nin\tO\n2\tO\nof\tO\nthese\tO\ncases\tO\nmyoclonus\tB-Disease\noccurred\tO\nsimultaneously\tO\n.\tO\n\nAlthough\tO\nonly\tO\nfew\tO\nclinical\tO\ndescriptions\tO\nof\tO\nthe\tO\nrelationship\tO\nbetween\tO\nhyperalgesia\tB-Disease\n/\tO\nmyoclonus\tB-Disease\nand\tO\nhigh\tO\ndoses\tO\nof\tO\nmorphine\tB-Chemical\nare\tO\navailable\tO\n,\tO\nexperimental\tO\nsupport\tO\nfrom\tO\nanimal\tO\nstudies\tO\nindicates\tO\nthat\tO\nmorphine\tB-Chemical\n,\tO\nor\tO\nits\tO\nmetabolites\tO\n,\tO\nplays\tO\na\tO\ncausative\tO\nrole\tO\nfor\tO\nthe\tO\nobserved\tO\nbehavioural\tO\nsyndrome\tO\n.\tO\n\nThe\tO\npossible\tO\nmechanisms\tO\nare\tO\ndiscussed\tO\nand\tO\ntreatment\tO\nproposals\tO\ngiven\tO\nsuggesting\tO\nthe\tO\nuse\tO\nof\tO\nmore\tO\nefficacious\tO\nopioids\tO\nwith\tO\nless\tO\nexcitatory\tO\npotency\tO\nin\tO\nthese\tO\nsituations\tO\n.\tO\n\nLiposomal\tO\ndaunorubicin\tB-Chemical\nin\tO\nadvanced\tO\nKaposi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nsarcoma\tI-Disease\n:\tO\na\tO\nphase\tO\nII\tO\nstudy\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\nnon\tO\n-\tO\nrandomized\tO\nPhase\tO\nII\tO\nclinical\tO\ntrial\tO\nto\tO\nassess\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\nliposomal\tO\ndaunorubicin\tB-Chemical\n(\tO\nDaunoXome\tO\n)\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nAIDS\tB-Disease\nrelated\tO\nKaposi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nsarcoma\tI-Disease\n.\tO\n\nEleven\tO\nhomosexual\tO\nmen\tO\nwith\tO\nadvanced\tO\nKaposi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nsarcoma\tI-Disease\nwere\tO\nentered\tO\nin\tO\nthe\tO\ntrial\tO\n.\tO\n\nChanges\tO\nin\tO\nsize\tO\n,\tO\ncolour\tO\nand\tO\nassociated\tO\noedema\tB-Disease\nof\tO\nselected\tO\n'\tO\ntarget\tO\n'\tO\nlesions\tO\nwere\tO\nmeasured\tO\n.\tO\n\nClinical\tO\n,\tO\nbiochemical\tO\nand\tO\nhaematological\tO\ntoxicities\tB-Disease\nwere\tO\nassessed\tO\n.\tO\n\nTen\tO\nsubjects\tO\nwere\tO\nevaluated\tO\n.\tO\n\nA\tO\npartial\tO\nresponse\tO\nwas\tO\nachieved\tO\nin\tO\nfour\tO\n,\tO\nof\tO\nwhom\tO\ntwo\tO\nsubsequently\tO\nrelapsed\tO\n.\tO\n\nStabilization\tO\nof\tO\nKaposi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nsarcoma\tI-Disease\noccurred\tO\nin\tO\nthe\tO\nremaining\tO\nsix\tO\n,\tO\nmaintained\tO\nuntil\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\ntrial\tO\nperiod\tO\nin\tO\nfour\tO\n.\tO\n\nThe\tO\ndrug\tO\nwas\tO\ngenerally\tO\nwell\tO\ntolerated\tO\n,\tO\nwith\tO\nfew\tO\nmild\tO\nsymptoms\tO\nof\tO\ntoxicity\tB-Disease\n.\tO\n\nThe\tO\nmain\tO\nproblem\tO\nencountered\tO\nwas\tO\nhaematological\tO\ntoxicity\tB-Disease\n,\tO\nwith\tO\nthree\tO\nsubjects\tO\nexperiencing\tO\nsevere\tO\nneutropenia\tB-Disease\n(\tO\nneutrophil\tO\ncount\tO\n<\tO\n0\tO\n.\tO\n5\tO\nx\tO\n10\tO\n(\tO\n9\tO\n)\tO\n/\tO\nl\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nevidence\tO\nof\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nIn\tO\nthis\tO\nsmall\tO\npatient\tO\nsample\tO\n,\tO\nliposomal\tO\ndaunorubicin\tB-Chemical\nwas\tO\nan\tO\neffective\tO\nand\tO\nwell\tO\ntolerated\tO\nagent\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nKaposi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nsarcoma\tI-Disease\n.\tO\n\nLong\tO\n-\tO\nterm\tO\neffects\tO\nof\tO\nvincristine\tB-Chemical\non\tO\nthe\tO\nperipheral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nForty\tO\npatients\tO\nwith\tO\nNon\tB-Disease\n-\tI-Disease\nHodgkin\tI-Disease\n'\tI-Disease\ns\tI-Disease\nLymphoma\tI-Disease\ntreated\tO\nwith\tO\nvincristine\tB-Chemical\nbetween\tO\n1984\tO\nand\tO\n1990\tO\n(\tO\ncumulative\tO\ndose\tO\n12\tO\nmg\tO\nin\tO\n18\tO\n-\tO\n24\tO\nweeks\tO\n)\tO\nwere\tO\ninvestigated\tO\nin\tO\norder\tO\nto\tO\nevaluate\tO\nthe\tO\nlong\tO\nterm\tO\neffects\tO\nof\tO\nvincristine\tB-Chemical\non\tO\nthe\tO\nperipheral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nThe\tO\npatients\tO\nwere\tO\ninterviewed\tO\nwith\tO\nemphasis\tO\non\tO\nneuropathic\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nPhysical\tO\nand\tO\nquantitative\tO\nsensory\tO\nexamination\tO\nwith\tO\ndetermination\tO\nof\tO\nvibratory\tO\nperception\tO\nand\tO\nthermal\tO\ndiscrimination\tO\nthresholds\tO\nwere\tO\nperformed\tO\n,\tO\nfour\tO\nto\tO\n77\tO\nmonths\tO\n(\tO\nmedian\tO\n34\tO\nmonths\tO\n)\tO\nafter\tO\nvincristine\tB-Chemical\ntreatment\tO\n.\tO\n\nTwenty\tO\n-\tO\nseven\tO\npatients\tO\nreported\tO\nneuropathic\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nIn\tO\n13\tO\nof\tO\nthese\tO\n27\tO\npatients\tO\nsymptoms\tO\nwere\tO\nstill\tO\npresent\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\nexamination\tO\n.\tO\n\nIn\tO\nthese\tO\npatients\tO\nsensory\tO\nsigns\tO\nand\tO\nsymptoms\tO\npredominated\tO\n.\tO\n\nIn\tO\nthe\tO\nother\tO\n14\tO\npatients\tO\nsymptoms\tO\nhad\tO\nbeen\tO\npresent\tO\nin\tO\nthe\tO\npast\tO\n.\tO\n\nSymptoms\tO\npersisted\tO\nmaximally\tO\n40\tO\nmonths\tO\nsince\tO\ncessation\tO\nof\tO\ntherapy\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nage\tO\ndifference\tO\nbetween\tO\npatients\tO\nwith\tO\nand\tO\nwithout\tO\ncomplaints\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\nexamination\tO\n.\tO\n\nNormal\tO\nreflexes\tO\nwere\tO\nfound\tO\nin\tO\ntwo\tO\nthird\tO\nof\tO\npatients\tO\n.\tO\n\nNeuropathic\tO\ncomplaints\tO\nwere\tO\nnot\tO\nvery\tO\ntroublesome\tO\non\tO\nthe\tO\nlong\tO\nterm\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nwith\tO\nthe\tO\nabove\tO\nmentioned\tO\nvincristine\tB-Chemical\ndose\tO\nschedule\tO\nsigns\tO\nand\tO\nsymptoms\tO\nof\tO\nvincristine\tB-Chemical\nneuropathy\tB-Disease\nare\tO\nreversible\tO\nfor\tO\na\tO\ngreat\tO\ndeal\tO\nand\tO\nprognosis\tO\nis\tO\nfairly\tO\ngood\tO\n.\tO\n\nHepatic\tO\nadenomas\tB-Disease\nand\tO\nfocal\tB-Disease\nnodular\tI-Disease\nhyperplasia\tI-Disease\nof\tO\nthe\tO\nliver\tO\nin\tO\nyoung\tO\nwomen\tO\non\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n:\tO\ncase\tO\nreports\tO\n.\tO\n\nTwo\tO\ncases\tO\nof\tO\nhepatic\tO\nadenoma\tB-Disease\nand\tO\none\tO\nof\tO\nfocal\tB-Disease\nnodular\tI-Disease\nhyperplasia\tI-Disease\npresumably\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n,\tO\nare\tO\nreported\tO\n.\tO\n\nSpecial\tO\nreference\tO\nis\tO\nmade\tO\nto\tO\ntheir\tO\nclinical\tO\npresentation\tO\n,\tO\nwhich\tO\nmay\tO\nbe\tO\ntotally\tO\nasymptomatic\tO\n.\tO\n\nLiver\tO\n-\tO\nfunction\tO\ntests\tO\nare\tO\nof\tO\nlittle\tO\ndiagnostic\tO\nvalue\tO\n,\tO\nbut\tO\nvaluable\tO\ninformation\tO\nmay\tO\nbe\tO\nobtained\tO\nfrom\tO\nboth\tO\nliver\tO\nscanning\tO\nand\tO\nhepatic\tO\nangiography\tO\n.\tO\n\nHistologic\tO\ndifferences\tO\nand\tO\nclinical\tO\nsimilarities\tO\nbetween\tO\nhepatic\tO\nadenoma\tB-Disease\nand\tO\nfocal\tB-Disease\nnodular\tI-Disease\nhyperplasia\tI-Disease\nof\tO\nthe\tO\nliver\tO\nare\tO\ndiscussed\tO\n.\tO\n\nLoss\tO\nof\tO\nglutamate\tB-Chemical\ndecarboxylase\tO\nmRNA\tO\n-\tO\ncontaining\tO\nneurons\tO\nin\tO\nthe\tO\nrat\tO\ndentate\tO\ngyrus\tO\nfollowing\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nIn\tO\nsitu\tO\nhybridization\tO\nmethods\tO\nwere\tO\nused\tO\nto\tO\ndetermine\tO\nif\tO\nglutamic\tB-Chemical\nacid\tI-Chemical\ndecarboxylase\tO\n(\tO\nGAD\tO\n)\tO\nmRNA\tO\n-\tO\ncontaining\tO\nneurons\tO\nwithin\tO\nthe\tO\nhilus\tO\nof\tO\nthe\tO\ndentate\tO\ngyrus\tO\nare\tO\nvulnerable\tO\nto\tO\nseizure\tB-Disease\n-\tO\ninduced\tO\ndamage\tO\nin\tO\na\tO\nmodel\tO\nof\tO\nchronic\tO\nseizures\tB-Disease\n.\tO\n\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\ninjected\tO\nintraperitoneally\tO\nwith\tO\npilocarpine\tB-Chemical\n,\tO\nand\tO\nthe\tO\nhippocampal\tO\nformation\tO\nwas\tO\nstudied\tO\nhistologically\tO\nat\tO\n1\tO\n,\tO\n2\tO\n,\tO\n4\tO\n,\tO\nand\tO\n8\tO\nweek\tO\nintervals\tO\nafter\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nIn\tO\nsitu\tO\nhybridization\tO\nhistochemistry\tO\n,\tO\nusing\tO\na\tO\ndigoxigenin\tB-Chemical\n-\tO\nlabeled\tO\nGAD\tO\ncRNA\tO\nprobe\tO\n,\tO\ndemonstrated\tO\na\tO\nsubstantial\tO\ndecrease\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nGAD\tO\nmRNA\tO\n-\tO\ncontaining\tO\nneurons\tO\nin\tO\nthe\tO\nhilus\tO\nof\tO\nthe\tO\ndentate\tO\ngyrus\tO\nin\tO\nthe\tO\npilocarpine\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nas\tO\ncompared\tO\nto\tO\ncontrols\tO\nat\tO\nall\tO\ntime\tO\nintervals\tO\n.\tO\n\nAdditional\tO\nneuronanatomical\tO\nstudies\tO\n,\tO\nincluding\tO\ncresyl\tB-Chemical\nviolet\tI-Chemical\nstaining\tO\n,\tO\nneuronal\tB-Disease\ndegeneration\tI-Disease\nmethods\tO\n,\tO\nand\tO\nhistochemical\tO\nlocalization\tO\nof\tO\nglial\tO\nfibrillary\tO\nacidic\tO\nprotein\tO\n,\tO\nsuggested\tO\nthat\tO\nthe\tO\ndecrease\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nGAD\tO\nmRNA\tO\n-\tO\ncontaining\tO\nneurons\tO\nwas\tO\nrelated\tO\nto\tO\nneuronal\tB-Disease\nloss\tI-Disease\nrather\tO\nthan\tO\nto\tO\na\tO\ndecrease\tO\nin\tO\nGAD\tO\nmRNA\tO\nlevels\tO\n.\tO\n\nThe\tO\nloss\tO\nof\tO\nGAD\tO\nmRNA\tO\n-\tO\ncontaining\tO\nneurons\tO\nin\tO\nthe\tO\nhilus\tO\ncontrasted\tO\nwith\tO\nthe\tO\nrelative\tO\npreservation\tO\nof\tO\nlabeled\tO\nputative\tO\nbasket\tO\ncells\tO\nalong\tO\nthe\tO\ninner\tO\nmargin\tO\nof\tO\nthe\tO\ngranule\tO\ncell\tO\nlayer\tO\n.\tO\n\nQuantitative\tO\nanalyses\tO\nof\tO\nlabeled\tO\nneurons\tO\nin\tO\nthree\tO\nregions\tO\nof\tO\nthe\tO\ndentate\tO\ngyrus\tO\nin\tO\nthe\tO\n1\tO\nand\tO\n2\tO\nweek\tO\ngroups\tO\nshowed\tO\nstatistically\tO\nsignificant\tO\ndecreases\tO\nin\tO\nthe\tO\nmean\tO\nnumber\tO\nof\tO\nGAD\tO\nmRNA\tO\n-\tO\ncontaining\tO\nneurons\tO\nin\tO\nthe\tO\nhilus\tO\nof\tO\nboth\tO\ngroups\tO\nof\tO\nexperimental\tO\nanimals\tO\n.\tO\n\nNo\tO\nsignificant\tO\ndifferences\tO\nwere\tO\nfound\tO\nin\tO\nthe\tO\nmolecular\tO\nlayer\tO\nor\tO\nthe\tO\ngranule\tO\ncell\tO\nlayer\tO\n,\tO\nwhich\tO\nincluded\tO\nlabeled\tO\nneurons\tO\nalong\tO\nthe\tO\nlower\tO\nmargin\tO\nof\tO\nthe\tO\ngranule\tO\ncell\tO\nlayer\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\n,\tO\nin\tO\nthis\tO\nmodel\tO\n,\tO\na\tO\nsubpopulation\tO\nof\tO\nGAD\tO\nmRNA\tO\n-\tO\ncontaining\tO\nneurons\tO\nwithin\tO\nthe\tO\ndentate\tO\ngyrus\tO\nis\tO\nselectively\tO\nvulnerable\tO\nto\tO\nseizure\tB-Disease\n-\tO\ninduced\tO\ndamage\tO\n.\tO\n\nSuch\tO\ndifferential\tO\nvulnerability\tO\nappears\tO\nto\tO\nbe\tO\nanother\tO\nindication\tO\nof\tO\nthe\tO\nheterogeneity\tO\nof\tO\nGABA\tB-Chemical\nneurons\tO\n.\tO\n\nEffects\tO\nof\tO\ndeliberate\tO\nhypotension\tB-Disease\ninduced\tO\nby\tO\nlabetalol\tB-Chemical\nwith\tO\nisoflurane\tB-Chemical\non\tO\nneuropsychological\tO\nfunction\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\ndeliberate\tO\nhypotension\tB-Disease\non\tO\nbrain\tO\nfunction\tO\nmeasured\tO\nby\tO\nneuropsychological\tO\ntests\tO\nwas\tO\nstudied\tO\nin\tO\n41\tO\nadult\tO\npatients\tO\n.\tO\n\nTwenty\tO\n-\tO\nfour\tO\npatients\tO\nwere\tO\nanaesthetized\tO\nfor\tO\nmiddle\tO\n-\tO\near\tO\nsurgery\tO\nwith\tO\ndeliberate\tO\nhypotension\tB-Disease\ninduced\tO\nby\tO\nlabetalol\tB-Chemical\nwith\tO\nisoflurane\tB-Chemical\n(\tO\nhypotensive\tB-Disease\ngroup\tO\n)\tO\n.\tO\n\nSeventeen\tO\npatients\tO\nwithout\tO\nhypotension\tB-Disease\nserved\tO\nas\tO\na\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nThe\tO\nmean\tO\narterial\tO\npressure\tO\nwas\tO\n77\tO\n+\tO\n/\tO\n-\tO\n2\tO\nmmHg\tO\n(\tO\n10\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n3\tO\nkPa\tO\n)\tO\nbefore\tO\nhypotension\tB-Disease\nand\tO\n50\tO\n+\tO\n/\tO\n-\tO\n0\tO\nmmHg\tO\n(\tO\n6\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n0\tO\nkPa\tO\n)\tO\nduring\tO\nhypotension\tB-Disease\nin\tO\nthe\tO\nhypotensive\tB-Disease\ngroup\tO\n,\tO\nand\tO\n86\tO\n+\tO\n/\tO\n-\tO\n2\tO\nmmHg\tO\n(\tO\n11\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n3\tO\nkPa\tO\n)\tO\nduring\tO\nanaesthesia\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nThe\tO\nfollowing\tO\npsychological\tO\ntests\tO\nwere\tO\nperformed\tO\n:\tO\nfour\tO\nsubtests\tO\nof\tO\nthe\tO\nWechsler\tO\nAdult\tO\nIntelligence\tO\nScale\tO\n(\tO\nsimilarities\tO\n,\tO\ndigit\tO\nspan\tO\n,\tO\nvocabulary\tO\nand\tO\ndigit\tO\nsymbol\tO\n)\tO\n,\tO\nTrail\tO\n-\tO\nMaking\tO\ntests\tO\nA\tO\nand\tO\nB\tO\n,\tO\nZung\tO\ntests\tO\n(\tO\nself\tO\n-\tO\nrating\tO\nanxiety\tB-Disease\nscale\tO\nand\tO\nself\tO\n-\tO\nrating\tO\ndepression\tB-Disease\nscale\tO\n)\tO\nand\tO\ntwo\tO\n-\tO\npart\tO\nmemory\tO\ntest\tO\nbattery\tO\nwith\tO\nimmediate\tO\nand\tO\ndelayed\tO\nrecall\tO\n.\tO\n\nThe\tO\ntests\tO\nwere\tO\nperformed\tO\npreoperatively\tO\nand\tO\n2\tO\ndays\tO\npostoperatively\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nstatistically\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\nthe\tO\ngroups\tO\nin\tO\nany\tO\nof\tO\nthe\tO\ntests\tO\nin\tO\nthe\tO\nchanges\tO\nfrom\tO\npreoperative\tO\nvalue\tO\nto\tO\npostoperative\tO\nvalue\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nhypotension\tB-Disease\ninduced\tO\nby\tO\nlabetalol\tB-Chemical\nwith\tO\nisoflurane\tB-Chemical\nhas\tO\nno\tO\nsignificant\tO\nharmful\tO\neffects\tO\non\tO\nmental\tO\nfunctions\tO\ncompared\tO\nto\tO\nnormotensive\tO\nanaesthesia\tO\n.\tO\n\nApparent\tO\ncure\tO\nof\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\nby\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\n.\tO\n\nWe\tO\ndescribe\tO\nthe\tO\ninduction\tO\nof\tO\nsustained\tO\nremissions\tO\nand\tO\npossible\tO\ncure\tO\nof\tO\nsevere\tO\nerosive\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n(\tO\nRA\tB-Disease\n)\tO\nby\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\n(\tO\nBMT\tO\n)\tO\nin\tO\n2\tO\npatients\tO\n.\tO\n\nBMT\tO\nwas\tO\nused\tO\nto\tO\ntreat\tO\nsevere\tO\naplastic\tB-Disease\nanemia\tI-Disease\nwhich\tO\nwas\tO\ncaused\tO\nby\tO\ngold\tB-Chemical\nin\tO\none\tO\ncase\tO\nand\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\nin\tO\nthe\tO\nother\tO\n.\tO\n\nIn\tO\nthe\tO\n8\tO\nand\tO\n6\tO\nyears\tO\nsince\tO\nthe\tO\ntransplants\tO\n(\tO\nrepresenting\tO\n8\tO\nand\tO\n4\tO\nyears\tO\nsince\tO\ncessation\tO\nof\tO\nall\tO\nimmunosuppressive\tO\ntherapy\tO\n,\tO\nrespectively\tO\n)\tO\n,\tO\nthe\tO\nRA\tB-Disease\nin\tO\neach\tO\ncase\tO\nhas\tO\nbeen\tO\ncompletely\tO\nquiescent\tO\n.\tO\n\nAlthough\tO\nshort\tO\nterm\tO\nremission\tO\nof\tO\nsevere\tO\nRA\tB-Disease\nfollowing\tO\nBMT\tO\nhas\tO\nbeen\tO\nreported\tO\n,\tO\nthese\tO\nare\tO\nthe\tO\nfirst\tO\ncases\tO\nfor\tO\nwhich\tO\nprolonged\tO\nfollowup\tO\nhas\tO\nbeen\tO\navailable\tO\n.\tO\n\nThis\tO\nexperience\tO\nraises\tO\nthe\tO\nquestion\tO\nof\tO\nthe\tO\nrole\tO\nof\tO\nBMT\tO\nitself\tO\nas\tO\na\tO\ntherapeutic\tO\noption\tO\nfor\tO\npatients\tO\nwith\tO\nuncontrolled\tO\ndestructive\tO\nsynovitis\tB-Disease\n.\tO\n\nSeizures\tB-Disease\ninduced\tO\nby\tO\ncombined\tO\nlevomepromazine\tB-Chemical\n-\tO\nfluvoxamine\tB-Chemical\ntreatment\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\ncombined\tO\nlevomepromazine\tB-Chemical\n-\tO\nfluvoxamine\tB-Chemical\ntreatment\tO\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nIt\tO\nseems\tO\nthat\tO\ncombined\tO\ntreatment\tO\nof\tO\nfluvoxamine\tB-Chemical\nwith\tO\nphenothiazines\tB-Chemical\nmay\tO\npossess\tO\nproconvulsive\tO\nactivity\tO\n.\tO\n\nCase\tO\nreport\tO\n:\tO\npentamidine\tB-Chemical\nand\tO\npolymorphic\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nrevisited\tO\n.\tO\n\nPentamidine\tB-Chemical\nisethionate\tI-Chemical\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nventricular\tB-Disease\ntachyarrhythmias\tI-Disease\n,\tO\nincluding\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n.\tO\n\nThis\tO\narticle\tO\nreports\tO\ntwo\tO\ncases\tO\nof\tO\nthis\tO\ncomplication\tO\nand\tO\nreviews\tO\nall\tO\nreported\tO\ncases\tO\nto\tO\ndate\tO\n.\tO\n\nPentamidine\tB-Chemical\n-\tO\ninduced\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nserum\tO\nmagnesium\tB-Chemical\nlevels\tO\nand\tO\nhypomagnesemia\tB-Disease\nmay\tO\nsynergistically\tO\ninduce\tO\ntorsade\tO\n.\tO\n\nTorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\noccurred\tO\nafter\tO\nan\tO\naverage\tO\nof\tO\n10\tO\ndays\tO\nof\tO\ntreatment\tO\nwith\tO\npentamidine\tB-Chemical\n.\tO\n\nIn\tO\nthese\tO\npatients\tO\n,\tO\nno\tO\nother\tO\nacute\tO\nside\tO\neffects\tO\nof\tO\npentamidine\tB-Chemical\nwere\tO\nobserved\tO\n.\tO\n\nTorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\ncan\tO\nbe\tO\ntreated\tO\nwhen\tO\nrecognized\tO\nearly\tO\n,\tO\npossibly\tO\nwithout\tO\ndiscontinuation\tO\nof\tO\npentamidine\tB-Chemical\n.\tO\n\nWhen\tO\nQTc\tB-Disease\ninterval\tI-Disease\nprolongation\tI-Disease\nis\tO\nobserved\tO\n,\tO\nearly\tO\nmagnesium\tB-Chemical\nsupplementation\tO\nis\tO\nadvocated\tO\n.\tO\n\nEfficacy\tO\nand\tO\ntolerability\tO\nof\tO\nlovastatin\tB-Chemical\nin\tO\n3390\tO\nwomen\tO\nwith\tO\nmoderate\tO\nhypercholesterolemia\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\nlovastatin\tB-Chemical\nin\tO\nwomen\tO\nwith\tO\nmoderate\tO\nhypercholesterolemia\tB-Disease\n.\tO\n\nDESIGN\tO\n:\tO\nThe\tO\nExpanded\tO\nClinical\tO\nEvaluation\tO\nof\tO\nLovastatin\tB-Chemical\n(\tO\nEXCEL\tO\n)\tO\nStudy\tO\n,\tO\na\tO\nmulticenter\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ndiet\tO\n-\tO\nand\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrial\tO\n,\tO\nin\tO\nwhich\tO\nparticipants\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nreceive\tO\nplacebo\tO\nor\tO\nlovastatin\tB-Chemical\nat\tO\ndoses\tO\nof\tO\n20\tO\nor\tO\n40\tO\nmg\tO\nonce\tO\ndaily\tO\n,\tO\nor\tO\n20\tO\nor\tO\n40\tO\nmg\tO\ntwice\tO\ndaily\tO\nfor\tO\n48\tO\nweeks\tO\n.\tO\n\nSETTING\tO\n:\tO\nAmbulatory\tO\npatients\tO\nrecruited\tO\nby\tO\n362\tO\nparticipating\tO\ncenters\tO\nthroughout\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tO\n\nPATIENTS\tO\n:\tO\nWomen\tO\n(\tO\nn\tO\n=\tO\n3390\tO\n)\tO\nfrom\tO\nthe\tO\ntotal\tO\ncohort\tO\nof\tO\n8245\tO\nvolunteers\tO\n.\tO\n\nMEASUREMENTS\tO\n:\tO\nPlasma\tO\ntotal\tO\n,\tO\nlow\tO\n-\tO\ndensity\tO\nlipoprotein\tO\n(\tO\nLDL\tO\n)\tO\n,\tO\nand\tO\nhigh\tO\n-\tO\ndensity\tO\nlipoprotein\tO\n(\tO\nHDL\tO\n)\tO\ncholesterol\tB-Chemical\n,\tO\nand\tO\ntriglycerides\tB-Chemical\n;\tO\nand\tO\nlaboratory\tO\nand\tO\nclinical\tO\nevidence\tO\nof\tO\nadverse\tO\nevents\tO\nmonitored\tO\nperiodically\tO\nthroughout\tO\nthe\tO\nstudy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAmong\tO\nwomen\tO\n,\tO\nlovastatin\tB-Chemical\n(\tO\n20\tO\nto\tO\n80\tO\nmg\tO\n/\tO\nd\tO\n)\tO\nproduced\tO\nsustained\tO\n(\tO\n12\tO\n-\tO\nto\tO\n48\tO\n-\tO\nweek\tO\n)\tO\n,\tO\ndose\tO\n-\tO\nrelated\tO\nchanges\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n:\tO\ndecreases\tO\nin\tO\nLDL\tO\ncholesterol\tB-Chemical\n(\tO\n24\tO\n%\tO\nto\tO\n40\tO\n%\tO\n)\tO\nand\tO\ntriglycerides\tB-Chemical\n(\tO\n9\tO\n%\tO\nto\tO\n18\tO\n%\tO\n)\tO\n,\tO\nand\tO\nincreases\tO\nin\tO\nHDL\tO\ncholesterol\tB-Chemical\n(\tO\n6\tO\n.\tO\n7\tO\n%\tO\nto\tO\n8\tO\n.\tO\n6\tO\n%\tO\n)\tO\n.\tO\n\nDepending\tO\non\tO\nthe\tO\ndose\tO\n,\tO\nfrom\tO\n82\tO\n%\tO\nto\tO\n95\tO\n%\tO\nof\tO\nlovastatin\tB-Chemical\n-\tO\ntreated\tO\nwomen\tO\nachieved\tO\nthe\tO\nNational\tO\nCholesterol\tB-Chemical\nEducation\tO\nProgram\tO\ngoal\tO\nof\tO\nLDL\tO\ncholesterol\tB-Chemical\nlevels\tO\nless\tO\nthan\tO\n4\tO\n.\tO\n14\tO\nmmol\tO\n/\tO\nL\tO\n(\tO\n160\tO\nmg\tO\n/\tO\ndL\tO\n)\tO\n,\tO\nand\tO\n40\tO\n%\tO\nto\tO\n87\tO\n%\tO\nachieved\tO\nthe\tO\ngoal\tO\nof\tO\n3\tO\n.\tO\n36\tO\nmmol\tO\n/\tO\nL\tO\n(\tO\n130\tO\nmg\tO\n/\tO\ndL\tO\n)\tO\n.\tO\n\nSuccessive\tO\ntransaminase\tO\nelevations\tO\ngreater\tO\nthan\tO\nthree\tO\ntimes\tO\nthe\tO\nupper\tO\nlimit\tO\nof\tO\nnormal\tO\noccurred\tO\nin\tO\n0\tO\n.\tO\n1\tO\n%\tO\nof\tO\nwomen\tO\nand\tO\nwere\tO\ndose\tO\ndependent\tO\nabove\tO\nthe\tO\n20\tO\n-\tO\nmg\tO\ndose\tO\n.\tO\n\nMyopathy\tB-Disease\n,\tO\ndefined\tO\nas\tO\nmuscle\tO\nsymptoms\tO\nwith\tO\ncreatine\tB-Chemical\nkinase\tO\nelevations\tO\ngreater\tO\nthan\tO\n10\tO\ntimes\tO\nthe\tO\nupper\tO\nlimit\tO\nof\tO\nnormal\tO\n,\tO\nwas\tO\nrare\tO\nand\tO\nassociated\tO\nwith\tO\nthe\tO\nhighest\tO\nrecommended\tO\ndaily\tO\ndose\tO\nof\tO\nlovastatin\tB-Chemical\n(\tO\n80\tO\nmg\tO\n)\tO\n.\tO\n\nEstrogen\tO\n-\tO\nreplacement\tO\ntherapy\tO\nappeared\tO\nto\tO\nhave\tO\nno\tO\neffect\tO\non\tO\neither\tO\nthe\tO\nefficacy\tO\nor\tO\nsafety\tO\nprofile\tO\nof\tO\nlovastatin\tB-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nLovastatin\tB-Chemical\nis\tO\nhighly\tO\neffective\tO\nand\tO\ngenerally\tO\nwell\tO\ntolerated\tO\nas\tO\ntherapy\tO\nfor\tO\nprimary\tO\nhypercholesterolemia\tB-Disease\nin\tO\nwomen\tO\n.\tO\n\nTetany\tB-Disease\nand\tO\nrhabdomyolysis\tB-Disease\ndue\tO\nto\tO\nsurreptitious\tO\nfurosemide\tB-Chemical\n-\tO\n-\tO\nimportance\tO\nof\tO\nmagnesium\tB-Chemical\nsupplementation\tO\n.\tO\n\nDiuretics\tO\nmay\tO\ninduce\tO\nhypokalemia\tB-Disease\n,\tO\nhypocalcemia\tB-Disease\nand\tO\nhypomagnesemia\tB-Disease\n.\tO\n\nWhile\tO\nsevere\tO\nhypokalemia\tB-Disease\nmay\tO\ncause\tO\nmuscle\tB-Disease\nweakness\tI-Disease\n,\tO\nsevere\tO\nhypomagnesemia\tB-Disease\nis\tO\nassociated\tO\nwith\tO\nmuscle\tB-Disease\nspasms\tI-Disease\nand\tO\ntetany\tB-Disease\nwhich\tO\ncannot\tO\nbe\tO\ncorrected\tO\nby\tO\npotassium\tB-Chemical\nand\tO\ncalcium\tB-Chemical\nsupplementation\tO\nalone\tO\n(\tO\n1\tO\n,\tO\n2\tO\n)\tO\n.\tO\n\nSurreptitious\tO\ndiuretic\tO\ningestion\tO\nhas\tO\nbeen\tO\ndescribed\tO\n,\tO\nmainly\tO\nin\tO\nwomen\tO\nwho\tO\nare\tO\nconcerned\tO\nthat\tO\nthey\tO\nare\tO\nobese\tB-Disease\nor\tO\nedematous\tB-Disease\n.\tO\n\nSymptomatic\tO\nhypokalemia\tB-Disease\nhas\tO\nbeen\tO\nreported\tO\nin\tO\nsuch\tO\npatients\tO\n(\tO\n3\tO\n-\tO\n7\tO\n)\tO\nand\tO\nin\tO\none\tO\ncase\tO\nhypocalcemia\tB-Disease\nwas\tO\nobserved\tO\n(\tO\n8\tO\n)\tO\n,\tO\nbut\tO\nthe\tO\neffects\tO\nof\tO\nmagnesium\tB-Chemical\ndepletion\tO\nwere\tO\nnot\tO\nnoted\tO\nin\tO\nthese\tO\npatients\tO\n.\tO\n\nCiprofloxacin\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\nin\tO\npatients\tO\nwith\tO\ncancer\tB-Disease\n.\tO\n\nNephrotoxicity\tB-Disease\nassociated\tO\nwith\tO\nciprofloxacin\tB-Chemical\nis\tO\nuncommon\tO\n.\tO\n\nFive\tO\npatients\tO\nwith\tO\ncancer\tB-Disease\nwho\tO\ndeveloped\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nthat\tO\nfollowed\tO\ntreatment\tO\nwith\tO\nciprofloxacin\tB-Chemical\nare\tO\ndescribed\tO\nand\tO\nan\tO\nadditional\tO\n15\tO\ncases\tO\nreported\tO\nin\tO\nthe\tO\nliterature\tO\nare\tO\nreviewed\tO\n.\tO\n\nOther\tO\nthan\tO\nelevation\tO\nof\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\n,\tO\ncharacteristic\tO\nclinical\tO\nmanifestations\tO\nand\tO\nabnormal\tO\nlaboratory\tO\nfindings\tO\nare\tO\nnot\tO\nfrequently\tO\npresent\tO\n.\tO\n\nAllergic\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nis\tO\nbelieved\tO\nto\tO\nbe\tO\nthe\tO\nunderlying\tO\npathological\tO\n-\tO\nprocess\tO\n.\tO\n\nDefinitive\tO\ndiagnosis\tO\nrequires\tO\nperformance\tO\nof\tO\nrenal\tO\nbiopsy\tO\n,\tO\nalthough\tO\nthis\tO\nis\tO\nnot\tO\nalways\tO\nfeasible\tO\n.\tO\n\nAn\tO\nimprovement\tO\nin\tO\nrenal\tO\nfunction\tO\nthat\tO\nfollowed\tO\nthe\tO\ndiscontinuation\tO\nof\tO\nthe\tO\noffending\tO\nantibiotic\tO\nsupports\tO\nthe\tO\npresumptive\tO\ndiagnosis\tO\nof\tO\nciprofloxacin\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nVenous\tB-Disease\ncomplications\tI-Disease\nof\tO\nmidazolam\tB-Chemical\nversus\tO\ndiazepam\tB-Chemical\n.\tO\n\nAlthough\tO\nsome\tO\nstudies\tO\nhave\tO\nsuggested\tO\nfewer\tO\nvenous\tB-Disease\ncomplications\tI-Disease\nare\tO\nassociated\tO\nwith\tO\nmidazolam\tB-Chemical\nthan\tO\nwith\tO\ndiazepam\tB-Chemical\nfor\tO\nendoscopic\tO\nprocedures\tO\n,\tO\nthis\tO\nvariable\tO\nhas\tO\nnot\tO\nbeen\tO\nwell\tO\ndocumented\tO\n.\tO\n\nWe\tO\nprospectively\tO\nevaluated\tO\nthe\tO\nincidence\tO\nof\tO\nvenous\tB-Disease\ncomplications\tI-Disease\nafter\tO\nintravenous\tO\ninjection\tO\nof\tO\ndiazepam\tB-Chemical\nor\tO\nmidazolam\tB-Chemical\nin\tO\n122\tO\nconsecutive\tO\npatients\tO\nundergoing\tO\ncolonoscopy\tO\nand\tO\nesophagogastroduodenoscopy\tO\n.\tO\n\nOverall\tO\n,\tO\nvenous\tB-Disease\ncomplications\tI-Disease\nwere\tO\nmore\tO\nfrequent\tO\nwith\tO\ndiazepam\tB-Chemical\n(\tO\n22\tO\nof\tO\n62\tO\npatients\tO\n)\tO\nthan\tO\nwith\tO\nmidazolam\tB-Chemical\n(\tO\n4\tO\nof\tO\n60\tO\npatients\tO\n)\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nA\tO\npalpable\tO\nvenous\tO\ncord\tO\nwas\tO\npresent\tO\nin\tO\n23\tO\n%\tO\n(\tO\n14\tO\nof\tO\n62\tO\n)\tO\nof\tO\npatients\tO\nin\tO\nthe\tO\ndiazepam\tB-Chemical\ngroup\tO\n,\tO\ncompared\tO\nwith\tO\n2\tO\n%\tO\n(\tO\n1\tO\nof\tO\n60\tO\npatients\tO\n)\tO\nin\tO\nthe\tO\nmidazolam\tB-Chemical\ngroup\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nPain\tB-Disease\nat\tO\nthe\tO\ninjection\tO\nsite\tO\noccurred\tO\nin\tO\n35\tO\n%\tO\n(\tO\n22\tO\nof\tO\n62\tO\n)\tO\nof\tO\npatients\tO\nin\tO\nthe\tO\ndiazepam\tB-Chemical\ngroup\tO\ncompared\tO\nwith\tO\n7\tO\n%\tO\n(\tO\n4\tO\nof\tO\n60\tO\npatients\tO\n)\tO\nin\tO\nthe\tO\nmidazolam\tB-Chemical\ngroup\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nSwelling\tB-Disease\nand\tO\nwarmth\tO\nat\tO\nthe\tO\ninjection\tO\nsite\tO\nwere\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nSmoking\tO\n,\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrug\tO\nuse\tO\n,\tO\nintravenous\tO\ncatheter\tO\nsite\tO\n,\tO\ndwell\tO\ntime\tO\nof\tO\nthe\tO\nneedle\tO\n,\tO\nalcohol\tB-Chemical\nuse\tO\n,\tO\nand\tO\npain\tB-Disease\nduring\tO\nthe\tO\ninjection\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nincidence\tO\nof\tO\nvenous\tB-Disease\ncomplications\tI-Disease\n.\tO\n\nClarithromycin\tB-Chemical\n-\tO\nassociated\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\non\tO\ncontinuous\tO\nambulatory\tO\nperitoneal\tO\ndialysis\tO\n.\tO\n\nVisual\tB-Disease\nhallucinations\tI-Disease\nare\tO\na\tO\nrare\tO\nevent\tO\nin\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nand\tO\nnot\tO\nrelated\tO\nto\tO\nuremia\tB-Disease\nper\tO\nse\tO\n.\tO\n\nUnreported\tO\nin\tO\nthe\tO\nliterature\tO\nis\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\noccurring\tO\nin\tO\nassociation\tO\nwith\tO\nthe\tO\nnew\tO\nmacrolide\tB-Chemical\nantibiotic\tO\n,\tO\nclarithromycin\tB-Chemical\n.\tO\n\nWe\tO\ndescribe\tO\nsuch\tO\na\tO\ncase\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n(\tO\nESRD\tB-Disease\n)\tO\nmaintained\tO\non\tO\ncontinuous\tO\nambulatory\tO\nperitoneal\tO\ndialysis\tO\n(\tO\nCAPD\tO\n)\tO\n.\tO\n\nThe\tO\ncombination\tO\nof\tO\na\tO\nrelatively\tO\nhigh\tO\ndose\tO\nof\tO\nclarithromycin\tB-Chemical\nin\tO\nface\tO\nof\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nin\tO\na\tO\nfunctionally\tO\nanephric\tO\npatient\tO\n,\tO\nwith\tO\nunderlying\tO\naluminum\tB-Chemical\nintoxication\tO\n,\tO\nmay\tO\nhave\tO\nfacilitated\tO\nthe\tO\nappearance\tO\nof\tO\nthis\tO\nneurotoxic\tB-Disease\nside\tO\neffect\tO\n.\tO\n\nIt\tO\nis\tO\nimportant\tO\nto\tO\nunderstand\tO\nthe\tO\npharmacokinetics\tO\nof\tO\nmedications\tO\nin\tO\nface\tO\nof\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nthe\tO\npossibility\tO\nof\tO\ndrug\tO\ninteractions\tO\n,\tO\nand\tO\nhow\tO\nthese\tO\nfactors\tO\nshould\tO\nhelp\tO\nguide\tO\nmedication\tO\ntherapy\tO\nin\tO\nthe\tO\nESRD\tB-Disease\npatient\tO\n.\tO\n\nChanges\tO\nin\tO\nperoxisomes\tO\nin\tO\npreneoplastic\tO\nliver\tO\nand\tO\nhepatoma\tB-Disease\nof\tO\nmice\tO\ninduced\tO\nby\tO\nalpha\tB-Chemical\n-\tI-Chemical\nbenzene\tI-Chemical\nhexachloride\tI-Chemical\n.\tO\n\nPeroxisomes\tO\nin\tO\nhepatomas\tB-Disease\nand\tO\nhyperplastic\tO\npreneoplastic\tO\nliver\tB-Disease\nlesions\tI-Disease\ninduced\tO\nin\tO\nmice\tO\nby\tO\n500\tO\nppm\tO\nalpha\tB-Chemical\n-\tI-Chemical\nbenzene\tI-Chemical\nhexachloride\tI-Chemical\nwere\tO\nexamined\tO\nhistochemically\tO\nand\tO\nelectron\tO\nmicroscopically\tO\n.\tO\n\nAlthough\tO\nmost\tO\nof\tO\nthe\tO\nhepatomas\tB-Disease\nwere\tO\nwell\tO\n-\tO\ndifferentiated\tO\ntumors\tB-Disease\nand\tO\ncontained\tO\na\tO\nconsiderable\tO\nnumber\tO\nof\tO\nperoxisomes\tO\n,\tO\nthe\tO\ntumor\tB-Disease\ncells\tO\ndid\tO\nnot\tO\nrespond\tO\nto\tO\nethyl\tB-Chemical\n-\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\np\tI-Chemical\n-\tI-Chemical\nchlorophenoxyisobutyrate\tI-Chemical\nwith\tO\nproliferation\tO\nof\tO\nperoxisomes\tO\n.\tO\n\nAt\tO\nthe\tO\n16th\tO\nweek\tO\nof\tO\ncarcinogen\tO\nfeeding\tO\n,\tO\nhyperplastic\tO\nnodules\tO\nappeared\tO\nand\tO\nadvanced\tO\nto\tO\nfurther\tO\nstages\tO\n.\tO\n\nA\tO\nmajority\tO\nof\tO\nthe\tO\nnodules\tO\nshowed\tO\na\tO\nconsiderable\tO\nnumber\tO\nof\tO\nperoxisomes\tO\nand\tO\nthe\tO\ninductive\tO\nproliferation\tO\nof\tO\nperoxisomes\tO\n.\tO\n\nWithin\tO\nthe\tO\nnodules\tO\n,\tO\nfoci\tO\nof\tO\nproliferation\tO\nof\tO\nthe\tO\ncells\tO\nthat\tO\nshowed\tO\nno\tO\ninducibility\tO\nof\tO\nproliferation\tO\nof\tO\nperoxisomes\tO\nappeared\tO\n.\tO\n\nThese\tO\ncells\tO\nproliferated\tO\nfurther\tO\n,\tO\nreplacing\tO\nthe\tO\nmost\tO\npart\tO\nof\tO\nthe\tO\nnodules\tO\n,\tO\nand\tO\nwith\tO\nthis\tO\nprocess\tO\nhepatomas\tB-Disease\nappeared\tO\nto\tO\nhave\tO\nbeen\tO\nformed\tO\n.\tO\n\nNo\tO\nabnormal\tO\nmatrical\tO\ninclusions\tO\nof\tO\nperoxisomes\tO\nwere\tO\nformed\tO\nin\tO\nthe\tO\ncells\tO\nof\tO\nhyperplastic\tO\nnodules\tO\nby\tO\nethyl\tB-Chemical\n-\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\np\tI-Chemical\n-\tI-Chemical\nchlorophenoxyisobutyrate\tI-Chemical\nunlike\tO\nin\tO\nthe\tO\ncase\tO\nof\tO\nrats\tO\n.\tO\n\nContribution\tO\nof\tO\nthe\tO\nsympathetic\tO\nnervous\tO\nsystem\tO\nto\tO\nsalt\tO\n-\tO\nsensitivity\tO\nin\tO\nlifetime\tO\ncaptopril\tB-Chemical\n-\tO\ntreated\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ntest\tO\nthe\tO\nhypothesis\tO\nthat\tO\n,\tO\nin\tO\nlifetime\tO\ncaptopril\tB-Chemical\n-\tO\ntreated\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n(\tO\nSHR\tO\n)\tO\n,\tO\nthe\tO\nsympathetic\tO\nnervous\tO\nsystem\tO\ncontributes\tO\nimportantly\tO\nto\tO\nthe\tO\nhypertensive\tB-Disease\neffect\tO\nof\tO\ndietary\tB-Chemical\nsodium\tI-Chemical\nchloride\tI-Chemical\nsupplementation\tO\n.\tO\n\nMETHODS\tO\n:\tO\nMale\tO\nSHR\tO\n(\tO\naged\tO\n6\tO\nweeks\tO\n)\tO\nthat\tO\nhad\tO\nbeen\tO\ntreated\tO\nfrom\tO\nconception\tO\nonward\tO\nwith\tO\neither\tO\ncaptopril\tB-Chemical\nor\tO\nvehicle\tO\nremained\tO\non\tO\na\tO\nbasal\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\ndiet\tO\nor\tO\nwere\tO\nfed\tO\na\tO\nhigh\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\ndiet\tO\n.\tO\n\nAfter\tO\n2\tO\nweeks\tO\n,\tO\nthe\tO\nrats\tO\nwere\tO\nsubjected\tO\nto\tO\nganglionic\tO\nblockade\tO\nand\tO\n2\tO\ndays\tO\nlater\tO\n,\tO\nan\tO\ninfusion\tO\nof\tO\nclonidine\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nLifetime\tO\ncaptopril\tB-Chemical\ntreatment\tO\nsignificantly\tO\nlowered\tO\nmean\tO\narterial\tO\npressure\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nIntravenous\tO\ninfusion\tO\nof\tO\nthe\tO\nganglionic\tO\nblocker\tO\nhexamethonium\tB-Chemical\nresulted\tO\nin\tO\na\tO\nrapid\tO\ndecline\tO\nin\tO\nMAP\tO\nthat\tO\neliminated\tO\nthe\tO\ndietary\tB-Chemical\nsodium\tI-Chemical\nchloride\tI-Chemical\n-\tO\ninduced\tO\nincrease\tB-Disease\nin\tI-Disease\nMAP\tI-Disease\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nInfusion\tO\nof\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\nalpha2\tB-Chemical\n-\tI-Chemical\nadrenergic\tI-Chemical\nreceptor\tI-Chemical\nagonist\tI-Chemical\nclonidine\tB-Chemical\nalso\tO\nresulted\tO\nin\tO\na\tO\ngreater\tO\nreduction\tO\nin\tO\nMAP\tO\nin\tO\nboth\tO\ngroups\tO\nof\tO\nSHR\tO\nthat\tO\nwere\tO\nfed\tO\nthe\tO\nhigh\tO\n(\tO\ncompared\tO\nwith\tO\nthe\tO\nbasal\tO\n)\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\ndiet\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\nboth\tO\nlifetime\tO\ncaptopril\tB-Chemical\n-\tO\ntreated\tO\nand\tO\ncontrol\tO\nSHR\tO\n,\tO\nthe\tO\nsympathetic\tO\nnervous\tO\nsystem\tO\ncontributes\tO\nto\tO\nthe\tO\npressor\tO\neffects\tO\nof\tO\na\tO\nhigh\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\ndiet\tO\n.\tO\n\nAngioedema\tB-Disease\nassociated\tO\nwith\tO\ndroperidol\tB-Chemical\nadministration\tO\n.\tO\n\nAngioedema\tB-Disease\n,\tO\nalso\tO\nknown\tO\nas\tO\nangioneurotic\tB-Disease\nedema\tI-Disease\nor\tO\nQuincke\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n,\tO\nis\tO\na\tO\nwell\tO\n-\tO\ndemarcated\tO\n,\tO\nlocalized\tO\nedema\tB-Disease\ninvolving\tO\nthe\tO\nsubcutaneous\tO\ntissues\tO\nthat\tO\nmay\tO\ncause\tO\nupper\tB-Disease\n-\tI-Disease\nairway\tI-Disease\nobstruction\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\npreviously\tO\nhealthy\tO\n19\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nno\tO\nknown\tO\ndrug\tB-Disease\nallergies\tI-Disease\nin\tO\nwhom\tO\nangioedema\tB-Disease\nwith\tO\nsignificant\tO\ntongue\tB-Disease\nswelling\tI-Disease\nand\tO\nprotrusion\tO\ndeveloped\tO\nwithin\tO\n10\tO\nminutes\tO\nof\tO\nthe\tO\nadministration\tO\nof\tO\na\tO\nsingle\tO\nIV\tO\ndose\tO\nof\tO\ndroperidol\tB-Chemical\n.\tO\n\nLate\tO\ncardiotoxicity\tB-Disease\nafter\tO\ntreatment\tO\nfor\tO\na\tO\nmalignant\tO\nbone\tB-Disease\ntumor\tI-Disease\n.\tO\n\nCardiac\tO\nfunction\tO\nwas\tO\nassessed\tO\nin\tO\nlong\tO\n-\tO\nterm\tO\nsurvivors\tO\nof\tO\nmalignant\tO\nbone\tB-Disease\ntumors\tI-Disease\nwho\tO\nwere\tO\ntreated\tO\naccording\tO\nto\tO\nRosen\tB-Chemical\n'\tI-Chemical\ns\tI-Chemical\nT5\tI-Chemical\nor\tI-Chemical\nT10\tI-Chemical\nprotocol\tI-Chemical\n,\tO\nboth\tO\nincluding\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nThirty\tO\n-\tO\none\tO\npatients\tO\n,\tO\nage\tO\n10\tO\n-\tO\n45\tO\nyears\tO\n(\tO\nmedian\tO\nage\tO\n17\tO\n.\tO\n8\tO\nyears\tO\n)\tO\nwere\tO\nevaluated\tO\n2\tO\n.\tO\n3\tO\n-\tO\n14\tO\n.\tO\n1\tO\nyears\tO\n(\tO\nmedian\tO\n8\tO\n.\tO\n9\tO\nyears\tO\n)\tO\nfollowing\tO\ncompletion\tO\nof\tO\ntreatment\tO\n.\tO\n\nCumulative\tO\ndoses\tO\nof\tO\ndoxorubicin\tB-Chemical\nwere\tO\n225\tO\n-\tO\n550\tO\nmg\tO\n/\tO\nm2\tO\n(\tO\nmedian\tO\ndose\tO\n360\tO\n)\tO\n.\tO\n\nThe\tO\nevaluation\tO\nconsisted\tO\nof\tO\na\tO\nhistory\tO\n,\tO\nphysical\tO\nexamination\tO\n,\tO\nelectrocardiogram\tO\n(\tO\nECG\tO\n)\tO\n,\tO\nsignal\tO\naveraged\tO\nECG\tO\n,\tO\n24\tO\n-\tO\nhour\tO\nambulatory\tO\nECG\tO\n,\tO\nechocardiography\tO\nand\tO\nradionuclide\tO\nangiography\tO\n.\tO\n\nEighteen\tO\nof\tO\n31\tO\n(\tO\n58\tO\n%\tO\n)\tO\npatients\tO\nshowed\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\n,\tO\ndefined\tO\nas\tO\nhaving\tO\none\tO\nor\tO\nmore\tO\nof\tO\nthe\tO\nfollowing\tO\nabnormalities\tO\n:\tO\nlate\tO\npotentials\tO\n,\tO\ncomplex\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\n,\tO\nleft\tO\nventricular\tB-Disease\ndilation\tI-Disease\n,\tO\ndecreased\tO\nshortening\tO\nfraction\tO\n,\tO\nor\tO\ndecreased\tO\nejection\tO\nfraction\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ncardiac\tB-Disease\nabnormalities\tI-Disease\nincreased\tO\nwith\tO\nlength\tO\nof\tO\nfollow\tO\n-\tO\nup\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nNo\tO\ncorrelation\tO\ncould\tO\nbe\tO\ndemonstrated\tO\nbetween\tO\ncumulative\tO\ndose\tO\nof\tO\ndoxorubicin\tB-Chemical\nand\tO\ncardiac\tO\nstatus\tO\n,\tO\nexcept\tO\nfor\tO\nheart\tO\nrate\tO\nvariability\tO\n.\tO\n\nWhen\tO\nadjusted\tO\nto\tO\nbody\tO\nsurface\tO\narea\tO\n,\tO\nthe\tO\nleft\tO\nventricular\tO\nposterior\tO\nwall\tO\nthickness\tO\n(\tO\nLVPW\tO\nindex\tO\n)\tO\nwas\tO\ndecreased\tO\nin\tO\nall\tO\npatients\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nis\tO\nhigh\tO\nand\tO\nincreases\tO\nwith\tO\nfollow\tO\n-\tO\nup\tO\n,\tO\nirrespective\tO\nof\tO\ncumulative\tO\ndose\tO\n.\tO\n\nLife\tO\n-\tO\nlong\tO\ncardiac\tO\nfollow\tO\n-\tO\nup\tO\nin\tO\nthese\tO\npatients\tO\nis\tO\nwarranted\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nour\tO\nstudy\tO\nsuggest\tO\nthat\tO\nheart\tO\nrate\tO\nvariability\tO\nand\tO\nLVPW\tO\nindex\tO\ncould\tO\nbe\tO\nsensitive\tO\nindicators\tO\nfor\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nAcute\tO\nblood\tO\npressure\tO\nelevations\tO\nwith\tO\ncaffeine\tB-Chemical\nin\tO\nmen\tO\nwith\tO\nborderline\tO\nsystemic\tO\nhypertension\tB-Disease\n.\tO\n\nWhether\tO\nthe\tO\nvasoconstrictive\tO\nactions\tO\nof\tO\ncaffeine\tB-Chemical\nare\tO\nenhanced\tO\nin\tO\nhypertensive\tB-Disease\npersons\tO\nhas\tO\nnot\tO\nbeen\tO\ndemonstrated\tO\n.\tO\n\nThus\tO\n,\tO\ncaffeine\tB-Chemical\n(\tO\n3\tO\n.\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nversus\tO\nplacebo\tO\nwas\tO\ntested\tO\nin\tO\n48\tO\nhealthy\tO\nmen\tO\n(\tO\naged\tO\n20\tO\nto\tO\n35\tO\nyears\tO\n)\tO\nselected\tO\nafter\tO\nscreening\tO\non\tO\n2\tO\nseparate\tO\noccasions\tO\n.\tO\n\nBorderline\tO\nhypertensive\tB-Disease\nmen\tO\n(\tO\nn\tO\n=\tO\n24\tO\n)\tO\nwere\tO\nselected\tO\nwith\tO\nscreening\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\nof\tO\n140\tO\nto\tO\n160\tO\nmm\tO\nHg\tO\nand\tO\n/\tO\nor\tO\ndiastolic\tO\nBP\tO\n90\tO\nto\tO\n99\tO\nmm\tO\nHg\tO\n.\tO\n\nLow\tO\n-\tO\nrisk\tO\ncontrols\tO\n(\tO\nn\tO\n=\tO\n24\tO\n)\tO\nreported\tO\nno\tO\nparental\tO\nhistory\tO\nof\tO\nhypertension\tB-Disease\nand\tO\nhad\tO\nscreening\tO\nBP\tO\n<\tO\n130\tO\n/\tO\n85\tO\nmm\tO\nHg\tO\n.\tO\n\nParticipants\tO\nwere\tO\nthen\tO\ntested\tO\non\tO\n2\tO\noccasions\tO\nafter\tO\n12\tO\n-\tO\nhour\tO\nabstinence\tO\nfrom\tO\ncaffeine\tB-Chemical\nin\tO\neach\tO\nof\tO\n2\tO\nprotocols\tO\n;\tO\nthis\tO\nrequired\tO\na\tO\ntotal\tO\nof\tO\n4\tO\nlaboratory\tO\nvisits\tO\n.\tO\n\nCaffeine\tB-Chemical\n-\tO\ninduced\tO\nchanges\tO\nin\tO\ndiastolic\tO\nBP\tO\nwere\tO\n2\tO\nto\tO\n3\tO\ntimes\tO\nlarger\tO\nin\tO\nborderline\tO\nsubjects\tO\nthan\tO\nin\tO\ncontrols\tO\n(\tO\n+\tO\n8\tO\n.\tO\n4\tO\nvs\tO\n+\tO\n3\tO\n.\tO\n8\tO\nmm\tO\nHg\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n,\tO\nand\tO\nwere\tO\nattributable\tO\nto\tO\nlarger\tO\nchanges\tO\nin\tO\nimpedance\tO\n-\tO\nderived\tO\nmeasures\tO\nof\tO\nsystemic\tO\nvascular\tO\nresistance\tO\n(\tO\n+\tO\n135\tO\nvs\tO\n+\tO\n45\tO\ndynes\tO\n.\tO\ns\tO\n.\tO\ncm\tO\n-\tO\n5\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n004\tO\n)\tO\n.\tO\n\nThese\tO\nfindings\tO\nwere\tO\nconsistent\tO\nand\tO\nreached\tO\nsignificance\tO\nin\tO\nboth\tO\nprotocols\tO\n.\tO\n\nThe\tO\npercentage\tO\nof\tO\nborderline\tO\nsubjects\tO\nin\tO\nwhom\tO\ndiastolic\tO\nBP\tO\nchanges\tO\nexceeded\tO\nthe\tO\nmedian\tO\ncontrol\tO\nresponse\tO\nwas\tO\n96\tO\n%\tO\n.\tO\n\nConsequently\tO\n,\tO\nwhereas\tO\nall\tO\nparticipants\tO\nexhibited\tO\nnormotensive\tO\nlevels\tO\nduring\tO\nthe\tO\nresting\tO\npredrug\tO\nbaseline\tO\n,\tO\n33\tO\n%\tO\nof\tO\nborderline\tO\nsubjects\tO\nachieved\tO\nhypertensive\tB-Disease\nBP\tO\nlevels\tO\nafter\tO\ncaffeine\tB-Chemical\ningestion\tO\n.\tO\n\nThus\tO\n,\tO\nin\tO\nborderline\tO\nhypertensive\tB-Disease\nmen\tO\n,\tO\nexaggerated\tO\nresponses\tO\nto\tO\ncaffeine\tB-Chemical\nwere\tO\n:\tO\nselective\tO\nfor\tO\ndiastolic\tO\nBP\tO\n,\tO\nconsistent\tO\nwith\tO\ngreater\tO\nvasoconstriction\tO\n,\tO\nreplicated\tO\nin\tO\n2\tO\nprotocols\tO\n,\tO\nand\tO\nrepresentative\tO\nof\tO\nnearly\tO\nall\tO\nborderline\tO\nhypertensives\tB-Disease\n.\tO\n\nWe\tO\nsuspect\tO\nthat\tO\nthe\tO\npotential\tO\nfor\tO\ncaffeine\tB-Chemical\nto\tO\nstabilize\tO\nhigh\tO\nresistance\tO\nstates\tO\nin\tO\nsusceptible\tO\npersons\tO\nsuggests\tO\nthat\tO\nits\tO\nuse\tO\nmay\tO\nfacilitate\tO\ntheir\tO\ndisease\tO\nprogression\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nhinder\tO\naccurate\tO\ndiagnosis\tO\nand\tO\ntreatment\tO\n.\tO\n\nAbsence\tO\nof\tO\neffect\tO\nof\tO\nsertraline\tB-Chemical\non\tO\ntime\tO\n-\tO\nbased\tO\nsensitization\tO\nof\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\nwith\tO\nhaloperidol\tB-Chemical\n.\tO\n\nThis\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nrandomized\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\nstudy\tO\nevaluated\tO\nthe\tO\neffects\tO\nof\tO\nhaloperidol\tB-Chemical\nalone\tO\nand\tO\nhaloperidol\tB-Chemical\nplus\tO\nsertraline\tB-Chemical\non\tO\ncognitive\tO\nand\tO\npsychomotor\tO\nfunction\tO\nin\tO\n24\tO\nhealthy\tO\nmale\tO\nsubjects\tO\n.\tO\n\nMETHOD\tO\n:\tO\nAll\tO\nsubjects\tO\nreceived\tO\nplacebo\tO\non\tO\nDay\tO\n1\tO\nand\tO\nhaloperidol\tB-Chemical\n2\tO\nmg\tO\non\tO\nDays\tO\n2\tO\nand\tO\n25\tO\n.\tO\n\nFrom\tO\nDays\tO\n9\tO\nto\tO\n25\tO\n,\tO\nsubjects\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\neither\tO\nsertraline\tB-Chemical\n(\tO\n12\tO\nsubjects\tO\n)\tO\nor\tO\nplacebo\tO\n(\tO\n12\tO\nsubjects\tO\n)\tO\n;\tO\nthe\tO\nsertraline\tB-Chemical\ndose\tO\nwas\tO\ntitrated\tO\nfrom\tO\n50\tO\nto\tO\n200\tO\nmg\tO\n/\tO\nday\tO\nfrom\tO\nDays\tO\n9\tO\nto\tO\n16\tO\n,\tO\nand\tO\nremained\tO\nat\tO\n200\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\nthe\tO\nfinal\tO\n10\tO\ndays\tO\nof\tO\nthe\tO\ndrug\tO\nadministration\tO\nperiod\tO\n.\tO\n\nCognitive\tO\nfunction\tO\ntesting\tO\nwas\tO\nperformed\tO\nbefore\tO\ndosing\tO\nand\tO\nover\tO\na\tO\n24\tO\n-\tO\nhour\tO\nperiod\tO\nafter\tO\ndosing\tO\non\tO\nDays\tO\n1\tO\n,\tO\n2\tO\n,\tO\nand\tO\n25\tO\n.\tO\n\nRESULTS\tO\n:\tO\nImpairment\tB-Disease\nof\tI-Disease\ncognitive\tI-Disease\nfunction\tI-Disease\nwas\tO\nobserved\tO\n6\tO\nto\tO\n8\tO\nhours\tO\nafter\tO\nadministration\tO\nof\tO\nhaloperidol\tB-Chemical\non\tO\nDay\tO\n2\tO\nbut\tO\nwas\tO\nnot\tO\nevident\tO\n23\tO\nhours\tO\nafter\tO\ndosing\tO\n.\tO\n\nWhen\tO\nsingle\tO\n-\tO\ndose\tO\nhaloperidol\tB-Chemical\nwas\tO\ngiven\tO\nagain\tO\n25\tO\ndays\tO\nlater\tO\n,\tO\ngreater\tO\nimpairment\tO\nwith\tO\nearlier\tO\nonset\tO\nwas\tO\nnoted\tO\nin\tO\nseveral\tO\ntests\tO\nin\tO\nboth\tO\ntreatment\tO\ngroups\tO\n,\tO\nsuggesting\tO\nenhancement\tO\nof\tO\nthis\tO\neffect\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nindication\tO\nthat\tO\nsertraline\tB-Chemical\nexacerbated\tO\nthe\tO\nimpairment\tO\nproduced\tO\nby\tO\nhaloperidol\tB-Chemical\nsince\tO\nan\tO\nequivalent\tO\neffect\tO\nalso\tO\noccurred\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\n.\tO\n\nThree\tO\nsubjects\tO\n(\tO\n2\tO\non\tO\nsertraline\tB-Chemical\nand\tO\n1\tO\non\tO\nplacebo\tO\n)\tO\nwithdrew\tO\nfrom\tO\nthe\tO\nstudy\tO\nbecause\tO\nof\tO\nside\tO\neffects\tO\n.\tO\n\nTen\tO\nsubjects\tO\nin\tO\neach\tO\ngroup\tO\nreported\tO\nside\tO\neffects\tO\nrelated\tO\nto\tO\ntreatment\tO\n.\tO\n\nThe\tO\nside\tO\neffect\tO\nprofiles\tO\nof\tO\nsertraline\tB-Chemical\nand\tO\nof\tO\nplacebo\tO\nwere\tO\nsimilar\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nHaloperidol\tB-Chemical\nproduced\tO\na\tO\nclear\tO\nprofile\tO\nof\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\nthat\tO\nwas\tO\nnot\tO\nworsened\tO\nby\tO\nconcomitant\tO\nsertraline\tB-Chemical\nadministration\tO\n.\tO\n\nCoexistence\tO\nof\tO\ncerebral\tB-Disease\nvenous\tI-Disease\nsinus\tI-Disease\nand\tI-Disease\ninternal\tI-Disease\ncarotid\tI-Disease\nartery\tI-Disease\nthrombosis\tI-Disease\nassociated\tO\nwith\tO\nexogenous\tO\nsex\tO\nhormones\tO\n.\tO\n\nA\tO\ncase\tO\nreport\tO\n.\tO\n\nA\tO\nforty\tO\n-\tO\nsix\tO\nyear\tO\n-\tO\nold\tO\npremenopausal\tO\nwoman\tO\ndeveloped\tO\nheadache\tB-Disease\n,\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\n,\tO\nleft\tO\nhemiparesis\tB-Disease\nand\tO\nseizure\tB-Disease\ntwo\tO\ndays\tO\nafter\tO\nparenteral\tO\nuse\tO\nof\tO\nprogesterone\tB-Chemical\nand\tO\nestradiol\tB-Chemical\n.\tO\n\nDiabetes\tB-Disease\nmellitus\tI-Disease\n(\tO\nDM\tB-Disease\n)\tO\nwas\tO\nfound\tO\nduring\tO\nadmission\tO\n.\tO\n\nComputed\tO\ntomography\tO\nshowed\tO\na\tO\nhemorrhagic\tB-Disease\ninfarct\tI-Disease\nin\tO\nthe\tO\nright\tO\nfrontal\tO\nlobe\tO\nand\tO\nincreased\tO\ndensity\tO\nin\tO\nthe\tO\nsuperior\tO\nsagittal\tO\nsinus\tO\n(\tO\nSSS\tO\n)\tO\n.\tO\n\nLeft\tO\ncarotid\tO\nangiography\tO\nfound\tO\nocclusion\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nleft\tI-Disease\ninternal\tI-Disease\ncarotid\tI-Disease\nartery\tI-Disease\n(\tO\nICA\tO\n)\tO\n.\tO\n\nRight\tO\ncarotid\tO\nangiograms\tO\nfailed\tO\nto\tO\nshow\tO\nthe\tO\nSSS\tO\nand\tO\ninferior\tO\nsagittal\tO\nsinus\tO\n,\tO\nsuggestive\tO\nof\tO\nvenous\tB-Disease\nsinus\tI-Disease\nthrombosis\tI-Disease\n.\tO\n\nCoexistence\tO\nof\tO\nthe\tO\ncerebral\tB-Disease\nartery\tI-Disease\nand\tI-Disease\nthe\tI-Disease\nvenous\tI-Disease\nsinus\tI-Disease\nocclusion\tI-Disease\nhas\tO\nbeen\tO\ndescribed\tO\ninfrequently\tO\n.\tO\n\nIn\tO\nthis\tO\ncase\tO\n,\tO\nthe\tO\nauthors\tO\npostulate\tO\nthat\tO\nthe\tO\nuse\tO\nof\tO\nestradiol\tB-Chemical\nand\tO\nprogesterone\tB-Chemical\nand\tO\nthe\tO\nunderlying\tO\nDM\tB-Disease\nincreased\tO\nvascular\tO\nthrombogenicity\tO\n,\tO\nwhich\tO\nprovided\tO\na\tO\ncommon\tO\ndenominator\tO\nfor\tO\nthrombosis\tB-Disease\nof\tI-Disease\nboth\tI-Disease\nthe\tI-Disease\nICA\tI-Disease\nand\tI-Disease\nthe\tI-Disease\nvenous\tI-Disease\nsinus\tI-Disease\n.\tO\n\nChemotherapy\tO\nof\tO\nadvanced\tO\ninoperable\tO\nnon\tB-Disease\n-\tI-Disease\nsmall\tI-Disease\ncell\tI-Disease\nlung\tI-Disease\ncancer\tI-Disease\nwith\tO\npaclitaxel\tB-Chemical\n:\tO\na\tO\nphase\tO\nII\tO\ntrial\tO\n.\tO\n\nPaclitaxel\tB-Chemical\n(\tO\nTaxol\tB-Chemical\n;\tO\nBristol\tO\n-\tO\nMyers\tO\nSquibb\tO\nCompany\tO\n,\tO\nPrinceton\tO\n,\tO\nNJ\tO\n)\tO\nhas\tO\ndemonstrated\tO\nsignificant\tO\nantineoplastic\tO\nactivity\tO\nagainst\tO\ndifferent\tO\ntumor\tB-Disease\ntypes\tO\n,\tO\nnotably\tO\novarian\tB-Disease\nand\tI-Disease\nbreast\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nTwo\tO\nphase\tO\nII\tO\ntrials\tO\nof\tO\n24\tO\n-\tO\nhour\tO\npaclitaxel\tB-Chemical\ninfusions\tO\nin\tO\nchemotherapy\tO\n-\tO\nnaive\tO\npatients\tO\nwith\tO\nstage\tO\nIIIB\tO\nor\tO\nIV\tO\nnon\tB-Disease\n-\tI-Disease\nsmall\tI-Disease\ncell\tI-Disease\nlung\tI-Disease\ncancer\tI-Disease\n(\tO\nNSCLC\tB-Disease\n)\tO\nreported\tO\nresponse\tO\nrates\tO\nof\tO\n21\tO\n%\tO\nand\tO\n24\tO\n%\tO\n.\tO\n\nLeukopenia\tB-Disease\nwas\tO\ndose\tO\nlimiting\tO\n:\tO\nas\tO\nmany\tO\nas\tO\n62\tO\n.\tO\n5\tO\n%\tO\nof\tO\npatients\tO\nexperienced\tO\ngrade\tO\n4\tO\nleukopenia\tB-Disease\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\na\tO\n3\tO\n-\tO\nhour\tO\npaclitaxel\tB-Chemical\ninfusion\tO\nin\tO\na\tO\nphase\tO\nII\tO\ntrial\tO\nin\tO\npatients\tO\nwith\tO\ninoperable\tO\nstage\tO\nIIIB\tO\nor\tO\nIV\tO\nNSCLC\tB-Disease\n.\tO\n\nThe\tO\n58\tO\npatients\tO\ntreated\tO\n(\tO\n41\tO\nmen\tO\nand\tO\n17\tO\nwomen\tO\n)\tO\nhad\tO\na\tO\nmedian\tO\nage\tO\nof\tO\n59\tO\nyears\tO\n(\tO\nage\tO\nrange\tO\n,\tO\n25\tO\nto\tO\n75\tO\n)\tO\nand\tO\na\tO\nperformance\tO\nstatus\tO\nof\tO\n0\tO\nthrough\tO\n2\tO\n.\tO\n\nMost\tO\npatients\tO\n(\tO\n72\tO\n.\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nstage\tO\nIV\tO\nNSCLC\tB-Disease\n.\tO\n\nPaclitaxel\tB-Chemical\n225\tO\nmg\tO\n/\tO\nm2\tO\nwas\tO\ninfused\tO\nover\tO\n3\tO\nhours\tO\nevery\tO\n3\tO\nweeks\tO\nwith\tO\nstandard\tO\nprophylactic\tO\npremedication\tO\n.\tO\n\nOf\tO\n50\tO\npatients\tO\nevaluable\tO\nfor\tO\nresponse\tO\n,\tO\n12\tO\n(\tO\n24\tO\n%\tO\n)\tO\nhad\tO\npartial\tO\nremission\tO\n,\tO\n26\tO\n(\tO\n52\tO\n%\tO\n)\tO\nhad\tO\nno\tO\nchange\tO\n,\tO\nand\tO\n12\tO\nhad\tO\ndisease\tO\nprogression\tO\n(\tO\n24\tO\n%\tO\n)\tO\n.\tO\n\nHematologic\tO\ntoxicities\tB-Disease\nwere\tO\nmild\tO\n:\tO\nonly\tO\none\tO\npatient\tO\n(\tO\n2\tO\n%\tO\n)\tO\ndeveloped\tO\ngrade\tO\n3\tO\nor\tO\n4\tO\nneutropenia\tB-Disease\n,\tO\nwhile\tO\n29\tO\n%\tO\nhad\tO\ngrade\tO\n1\tO\nor\tO\n2\tO\n.\tO\n\nGrade\tO\n1\tO\nor\tO\n2\tO\npolyneuropathy\tB-Disease\naffected\tO\n56\tO\n%\tO\nof\tO\npatients\tO\nwhile\tO\nonly\tO\none\tO\n(\tO\n2\tO\n%\tO\n)\tO\nexperienced\tO\nsevere\tO\npolyneuropathy\tB-Disease\n.\tO\n\nSimilarly\tO\n,\tO\ngrade\tO\n1\tO\nor\tO\n2\tO\nmyalgia\tB-Disease\n/\tO\narthralgia\tB-Disease\nwas\tO\nobserved\tO\nin\tO\n63\tO\n.\tO\n2\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nbut\tO\nonly\tO\n14\tO\n.\tO\n3\tO\n%\tO\nexperienced\tO\ngrade\tO\n3\tO\nor\tO\n4\tO\n.\tO\n\nNausea\tB-Disease\nand\tO\nvomiting\tB-Disease\nwere\tO\ninfrequent\tO\n,\tO\nwith\tO\n14\tO\n%\tO\nof\tO\npatients\tO\nexperiencing\tO\ngrade\tO\n1\tO\nor\tO\n2\tO\nand\tO\nonly\tO\n2\tO\n%\tO\nexperiencing\tO\ngrade\tO\n3\tO\nor\tO\n4\tO\n.\tO\n\nPaclitaxel\tB-Chemical\nis\tO\nthus\tO\nan\tO\nactive\tO\nsingle\tO\nagent\tO\nin\tO\nthis\tO\npatient\tO\npopulation\tO\n,\tO\nwith\tO\na\tO\n3\tO\n-\tO\nhour\tO\ninfusion\tO\nproving\tO\ncomparably\tO\neffective\tO\nto\tO\na\tO\n24\tO\n-\tO\nhour\tO\ninfusion\tO\nand\tO\nsuperior\tO\nin\tO\nterms\tO\nof\tO\nthe\tO\nincidence\tO\nof\tO\nhematologic\tO\nand\tO\nnonhematologic\tO\ntoxicity\tB-Disease\n.\tO\n\nFurther\tO\nphase\tO\nII\tO\nstudies\tO\nwith\tO\npaclitaxel\tB-Chemical\ncombined\tO\nwith\tO\nother\tO\ndrugs\tO\nactive\tO\nagainst\tO\nNSCLC\tB-Disease\nare\tO\nindicated\tO\n,\tO\nand\tO\nphase\tO\nIII\tO\nstudies\tO\ncomparing\tO\npaclitaxel\tB-Chemical\nwith\tO\nstandard\tO\nchemotherapy\tO\nremain\tO\nto\tO\nbe\tO\ncompleted\tO\n.\tO\n\nPaclitaxel\tB-Chemical\ncombined\tO\nwith\tO\ncarboplatin\tB-Chemical\nin\tO\nthe\tO\nfirst\tO\n-\tO\nline\tO\ntreatment\tO\nof\tO\nadvanced\tO\novarian\tB-Disease\ncancer\tI-Disease\n.\tO\n\nIn\tO\na\tO\nphase\tO\nI\tO\nstudy\tO\nto\tO\ndetermine\tO\nthe\tO\nmaximum\tO\ntolerated\tO\ndose\tO\nof\tO\npaclitaxel\tB-Chemical\n(\tO\nTaxol\tB-Chemical\n;\tO\nBristol\tO\n-\tO\nMyers\tO\nSquibb\tO\nCompany\tO\n,\tO\nPrinceton\tO\n,\tO\nNJ\tO\n)\tO\ngiven\tO\nas\tO\na\tO\n3\tO\n-\tO\nhour\tO\ninfusion\tO\nin\tO\ncombination\tO\nwith\tO\ncarboplatin\tB-Chemical\nadministered\tO\nevery\tO\n21\tO\ndays\tO\nto\tO\nwomen\tO\nwith\tO\nadvanced\tO\novarian\tB-Disease\ncancer\tI-Disease\n,\tO\npaclitaxel\tB-Chemical\ndoses\tO\nwere\tO\nescalated\tO\nas\tO\nfollows\tO\n:\tO\nlevel\tO\n1\tO\n,\tO\n135\tO\nmg\tO\n/\tO\nm2\tO\n;\tO\nlevel\tO\n2\tO\n,\tO\n160\tO\nmg\tO\n/\tO\nm2\tO\n;\tO\nlevel\tO\n3\tO\n,\tO\n185\tO\nmg\tO\n/\tO\nm2\tO\n;\tO\nand\tO\nlevel\tO\n4\tO\n,\tO\n210\tO\nmg\tO\n/\tO\nm2\tO\n.\tO\n\nThe\tO\nfixed\tO\ndose\tO\nof\tO\ncarboplatin\tB-Chemical\nat\tO\nlevels\tO\n1\tO\nthrough\tO\n4\tO\nwas\tO\ngiven\tO\nto\tO\nachieve\tO\nan\tO\narea\tO\nunder\tO\nthe\tO\nconcentration\tO\n-\tO\ntime\tO\ncurve\tO\n(\tO\nAUC\tO\n)\tO\nof\tO\n5\tO\nusing\tO\nthe\tO\nCalvert\tO\nformula\tO\n.\tO\n\nIn\tO\nlevels\tO\n5\tO\nand\tO\n6\tO\nthe\tO\ncarboplatin\tB-Chemical\ndose\tO\nwas\tO\ntargeted\tO\nat\tO\nAUCs\tO\nof\tO\n6\tO\nand\tO\n7\tO\n.\tO\n5\tO\n,\tO\nrespectively\tO\n,\tO\ncombined\tO\nwith\tO\na\tO\nfixed\tO\npaclitaxel\tB-Chemical\ndose\tO\nof\tO\n185\tO\nmg\tO\n/\tO\nm2\tO\n.\tO\n\nTo\tO\ndate\tO\n,\tO\n30\tO\npreviously\tO\nuntreated\tO\npatients\tO\n,\tO\nall\tO\nwith\tO\na\tO\ngood\tO\nperformance\tO\nstatus\tO\n(\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\n0\tO\nto\tO\n2\tO\n)\tO\nhave\tO\nbeen\tO\nentered\tO\ninto\tO\nthis\tO\nongoing\tO\nstudy\tO\n.\tO\n\nThe\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicity\tB-Disease\nof\tO\nthe\tO\ncombination\tO\nwas\tO\nmyelosuppression\tB-Disease\n(\tO\nleukopenia\tB-Disease\n,\tO\ngranulocytopenia\tB-Disease\n,\tO\nand\tO\nthrombocytopenia\tB-Disease\n)\tO\n.\tO\n\nNeurotoxicity\tB-Disease\nwas\tO\nlargely\tO\nmoderate\tO\n.\tO\n\nSo\tO\nfar\tO\n,\tO\n14\tO\npatients\tO\nare\tO\nevaluable\tO\nfor\tO\nresponse\tO\n;\tO\nof\tO\nthese\tO\n,\tO\neight\tO\n(\tO\n57\tO\n%\tO\n)\tO\nshowed\tO\nobjective\tO\n(\tO\ncomplete\tO\nor\tO\npartial\tO\n)\tO\nresponse\tO\nand\tO\ndisease\tO\nstabilized\tO\nin\tO\nsix\tO\npatients\tO\n.\tO\n\nNo\tO\npatient\tO\nhad\tO\ndisease\tO\nprogression\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nthe\tO\ncombination\tO\nof\tO\npaclitaxel\tB-Chemical\n185\tO\nmg\tO\n/\tO\nm2\tO\nadministered\tO\nas\tO\na\tO\n3\tO\n-\tO\nhour\tO\ninfusion\tO\nfollowed\tO\nimmediately\tO\nby\tO\na\tO\n1\tO\n-\tO\nhour\tO\ninfusion\tO\nof\tO\ncarboplatin\tB-Chemical\nat\tO\nan\tO\nAUC\tO\nof\tO\n6\tO\ncan\tO\nbe\tO\nadministered\tO\nsafely\tO\nin\tO\na\tO\n21\tO\n-\tO\nday\tO\nschedule\tO\nin\tO\nthe\tO\noutpatient\tO\nsetting\tO\n.\tO\n\nThe\tO\nrecommended\tO\ndose\tO\nfor\tO\nphase\tO\nIII\tO\nstudies\tO\nis\tO\npaclitaxel\tB-Chemical\n185\tO\nmg\tO\n/\tO\nm2\tO\nand\tO\ncarboplatin\tB-Chemical\nAUC\tO\n6\tO\n.\tO\n\nEffects\tO\nof\tO\nacute\tO\nsteroid\tB-Chemical\nadministration\tO\non\tO\nventilatory\tO\nand\tO\nperipheral\tO\nmuscles\tO\nin\tO\nrats\tO\n.\tO\n\nOccasional\tO\ncase\tO\nreports\tO\nhave\tO\nshown\tO\nthat\tO\nacute\tO\nmyopathy\tB-Disease\nmay\tO\noccur\tO\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nmassive\tO\ndoses\tO\nof\tO\ncorticosteroids\tB-Chemical\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\nthis\tO\nmyopathy\tB-Disease\nis\tO\npoorly\tO\nunderstood\tO\n.\tO\n\nTherefore\tO\n,\tO\n60\tO\nmale\tO\nrats\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nreceive\tO\ndaily\tO\ninjection\tO\nof\tO\nsaline\tO\n(\tO\nC\tO\n)\tO\n,\tO\nmethylprednisolone\tB-Chemical\n(\tO\nM\tB-Chemical\n)\tO\n,\tO\nor\tO\ntriamcinolone\tB-Chemical\n(\tO\nT\tB-Chemical\n)\tO\n80\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nd\tO\nfor\tO\n5\tO\nd\tO\n.\tO\n\nNutritional\tO\nintake\tO\n,\tO\nmeasured\tO\ndaily\tO\nin\tO\n15\tO\nanimals\tO\n,\tO\nshowed\tO\na\tO\nsignificant\tO\nreduction\tB-Disease\nof\tI-Disease\nfood\tI-Disease\nintake\tI-Disease\nin\tO\nthe\tO\nsteroid\tB-Chemical\n-\tO\ntreated\tO\ngroups\tO\n(\tO\n-\tO\n50\tO\nand\tO\n-\tO\n79\tO\n%\tO\nin\tO\nM\tB-Chemical\nand\tO\nT\tB-Chemical\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nThis\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nsimilar\tO\nloss\tB-Disease\nin\tI-Disease\nbody\tI-Disease\nweight\tI-Disease\n.\tO\n\nIn\tO\nthe\tO\n45\tO\nremaining\tO\nanimals\tO\n,\tO\ndiaphragm\tO\ncontractility\tO\nand\tO\nhistopathologic\tO\nfeatures\tO\nof\tO\nseveral\tO\nmuscles\tO\nwere\tO\nstudied\tO\n.\tO\n\nWeights\tO\nof\tO\nrespiratory\tO\nand\tO\nperipheral\tO\nmuscles\tO\nwere\tO\nsimilarly\tO\ndecreased\tO\nafter\tO\nsteroid\tB-Chemical\ntreatment\tO\n.\tO\n\nMaximal\tO\ntwitches\tO\nof\tO\nthe\tO\ndiaphragm\tO\nwere\tO\nlower\tO\nin\tO\nthe\tO\nC\tO\ngroup\tO\n(\tO\n653\tO\n+\tO\n/\tO\n-\tO\n174\tO\ng\tO\n/\tO\ncm\tO\n(\tO\n2\tO\n)\tO\n)\tO\nthan\tO\nin\tO\nthe\tO\nM\tB-Chemical\ngroup\tO\n(\tO\n837\tO\n+\tO\n/\tO\n-\tO\n171\tO\ng\tO\n/\tO\ncm\tO\n(\tO\n2\tO\n)\tO\n;\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nthe\tO\nT\tB-Chemical\ngroup\tO\n(\tO\n765\tO\n+\tO\n/\tO\n-\tO\n145\tO\ng\tO\n/\tO\ncm\tO\n(\tO\n2\tO\n)\tO\n,\tO\nNS\tO\n)\tO\n.\tO\n\nHalf\tO\n-\tO\nrelaxation\tO\ntime\tO\nwas\tO\nprolonged\tO\nin\tO\nboth\tO\nsteroid\tB-Chemical\ngroups\tO\n,\tO\nand\tO\ntime\tO\nto\tO\npeak\tO\ntension\tO\nwas\tO\nlonger\tO\nwith\tO\nM\tB-Chemical\n,\tO\nwhereas\tO\ntetanic\tB-Disease\ntensions\tO\nwere\tO\nsimilar\tO\n.\tO\n\nSteroid\tB-Chemical\ntreatment\tO\nalso\tO\ninduced\tO\na\tO\nleftward\tO\nshift\tO\nof\tO\nthe\tO\nforce\tO\n-\tO\nfrequency\tO\ncurve\tO\nat\tO\n25\tO\nand\tO\n50\tO\nHz\tO\nwhen\tO\ncompared\tO\nwith\tO\nsaline\tO\ntreatment\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nATPase\tO\nstaining\tO\nof\tO\nthe\tO\ndiaphragm\tO\n,\tO\nscalenus\tO\nmedius\tO\n,\tO\nand\tO\ngastrocnemius\tO\nshowed\tO\ntype\tO\nIIb\tO\nfiber\tO\natrophy\tB-Disease\nin\tO\nthe\tO\nsteroid\tB-Chemical\ngroups\tO\nand\tO\nalso\tO\ndiaphragmatic\tO\ntype\tO\nIIa\tO\natrophy\tB-Disease\nwith\tO\nT\tB-Chemical\n,\tO\nwhereas\tO\nhistologic\tO\nexaminations\tO\nrevealed\tO\na\tO\nnormal\tO\nmuscular\tO\npattern\tO\nwith\tO\nabsence\tO\nof\tO\nnecrosis\tB-Disease\n.\tO\n\nFinally\tO\n,\tO\na\tO\npair\tO\n-\tO\nfed\tO\n(\tO\nPF\tO\n)\tO\nstudy\tO\n,\tO\nperformed\tO\nin\tO\n18\tO\nrats\tO\n(\tO\nC\tO\n,\tO\nT\tB-Chemical\n,\tO\nand\tO\nPF\tO\n)\tO\n,\tO\nshowed\tO\nthat\tO\nmuscle\tB-Disease\natrophy\tI-Disease\nwas\tO\nconsiderably\tO\nless\tO\npronounced\tO\nin\tO\nPF\tO\nanimals\tO\nthan\tO\nin\tO\nT\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\n(\tO\n1\tO\n)\tO\nshort\tO\n-\tO\nterm\tO\ntreatment\tO\nwith\tO\nmassive\tO\ndoses\tO\nof\tO\nsteroids\tB-Chemical\ninduced\tO\nsevere\tO\nrespiratory\tO\nand\tO\nlimb\tO\nmuscle\tO\nwasting\tO\n;\tO\n(\tO\n2\tO\n)\tO\nboth\tO\ntypes\tO\nof\tO\nsteroids\tB-Chemical\ninduced\tO\npredominantly\tO\ntype\tO\nIIb\tO\natrophy\tB-Disease\n,\tO\nresulting\tO\nin\tO\nthe\tO\nexpected\tO\nalterations\tO\nin\tO\ndiaphragm\tO\ncontractile\tO\nproperties\tO\n;\tO\n(\tO\n3\tO\n)\tO\nneither\tO\nsteroid\tB-Chemical\ncaused\tO\nmuscle\tO\nnecrosis\tB-Disease\n;\tO\n(\tO\n4\tO\n)\tO\ntype\tO\nIIb\tO\natrophy\tB-Disease\nwas\tO\nnot\tO\ncaused\tO\nby\tO\nacute\tO\nnutritional\tO\ndeprivation\tO\nalone\tO\n.\tO\n\nContinuous\tO\nsubcutaneous\tO\nadministration\tO\nof\tO\nmesna\tB-Chemical\nto\tO\nprevent\tO\nifosfamide\tB-Chemical\n-\tO\ninduced\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nHemorrhagic\tB-Disease\ncystitis\tI-Disease\nis\tO\na\tO\nmajor\tO\npotential\tO\ntoxicity\tB-Disease\nof\tO\nifosfamide\tB-Chemical\nthat\tO\ncan\tO\nbe\tO\nprevented\tO\nby\tO\nadministering\tO\nmesna\tB-Chemical\nalong\tO\nwith\tO\nthe\tO\ncytotoxic\tO\nagent\tO\n.\tO\n\nMesna\tB-Chemical\nis\tO\ngenerally\tO\nadministered\tO\nby\tO\nthe\tO\nintravenous\tO\nroute\tO\n,\tO\nalthough\tO\nexperience\tO\nwith\tO\noral\tO\ndelivery\tO\nof\tO\nthe\tO\ndrug\tO\nhas\tO\nincreased\tO\n.\tO\n\nThe\tO\ncontinuous\tO\nsubcutaneous\tO\nadministration\tO\nof\tO\nmesna\tB-Chemical\nhas\tO\nthe\tO\nadvantage\tO\nof\tO\nnot\tO\nrequiring\tO\nintravenous\tO\naccess\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nsubcutaneous\tO\ndelivery\tO\nof\tO\nthe\tO\nneutralizing\tO\nagent\tO\nwill\tO\nnot\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nrisk\tO\nof\tO\ninadequate\tO\nurinary\tO\nmesna\tB-Chemical\nconcentrations\tO\n,\tO\nsuch\tO\nas\tO\nin\tO\na\tO\npatient\tO\ntaking\tO\noral\tO\nmesna\tB-Chemical\nwho\tO\nexperiences\tO\nsevere\tO\nifosfamide\tB-Chemical\n-\tO\ninduced\tO\nemesis\tB-Disease\nand\tO\nis\tO\nunable\tO\nto\tO\nabsorb\tO\nthe\tO\ndrug\tO\n.\tO\n\nLimited\tO\nclinical\tO\nexperience\tO\nwith\tO\ncontinuous\tO\nsubcutaneous\tO\nmesna\tB-Chemical\nadministration\tO\nsuggests\tO\nit\tO\nis\tO\na\tO\nsafe\tO\n,\tO\npractical\tO\n,\tO\nand\tO\neconomic\tO\nmethod\tO\nof\tO\ndrug\tO\ndelivery\tO\nthat\tO\npermits\tO\nifosfamide\tB-Chemical\nto\tO\nbe\tO\nadministered\tO\nsuccessfully\tO\nin\tO\nthe\tO\noutpatient\tO\nsetting\tO\n.\tO\n\nLeg\tB-Disease\nand\tI-Disease\nback\tI-Disease\npain\tI-Disease\nafter\tO\nspinal\tO\nanaesthesia\tO\ninvolving\tO\nhyperbaric\tO\n5\tO\n%\tO\nlignocaine\tB-Chemical\n.\tO\n\nFifty\tO\n-\tO\nfour\tO\npatients\tO\n,\tO\naged\tO\n27\tO\n-\tO\n90\tO\nyears\tO\n,\tO\nwho\tO\nwere\tO\ngiven\tO\nlignocaine\tB-Chemical\n5\tO\n%\tO\nin\tO\n6\tO\n.\tO\n8\tO\n%\tO\nglucose\tB-Chemical\nsolution\tO\nfor\tO\nspinal\tO\nanaesthesia\tO\nwere\tO\nstudied\tO\n.\tO\n\nThirteen\tO\nof\tO\nthese\tO\npatients\tO\nexperienced\tO\npain\tB-Disease\nin\tI-Disease\nthe\tI-Disease\nlegs\tI-Disease\nand\tI-Disease\n/\tI-Disease\nor\tI-Disease\nback\tI-Disease\nafter\tO\nrecovery\tO\nfrom\tO\nanaesthesia\tO\n.\tO\n\nThe\tO\npatients\tO\naffected\tO\nwere\tO\nyounger\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nthe\tO\nsite\tO\nof\tO\nthe\tO\ndural\tO\npuncture\tO\nwas\tO\nhigher\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nthan\tO\nthose\tO\nindividuals\tO\nwithout\tO\npain\tB-Disease\n.\tO\n\nFive\tO\nof\tO\nthe\tO\n13\tO\npatients\tO\n(\tO\n38\tO\n%\tO\n)\tO\nwith\tO\npain\tB-Disease\nand\tO\nseven\tO\nof\tO\nthe\tO\n41\tO\npatients\tO\n(\tO\n17\tO\n%\tO\n)\tO\nwithout\tO\npain\tB-Disease\nadmitted\tO\nto\tO\na\tO\nhigh\tO\nalcohol\tB-Chemical\nintake\tO\n,\tO\nwhich\tO\nmight\tO\nbe\tO\na\tO\ncontributing\tO\nfactor\tO\n.\tO\n\nLeg\tB-Disease\nand\tI-Disease\n/\tI-Disease\nor\tI-Disease\nback\tI-Disease\npain\tI-Disease\nis\tO\nassociated\tO\nwith\tO\nthe\tO\nintrathecal\tO\nuse\tO\nof\tO\nhyperbaric\tO\n5\tO\n%\tO\nlignocaine\tB-Chemical\n.\tO\n\nThe\tO\nuse\tO\nof\tO\nserum\tO\ncholinesterase\tO\nin\tO\nsuccinylcholine\tB-Chemical\napnoea\tB-Disease\n.\tO\n\nFifteen\tO\npatients\tO\ndemonstrating\tO\nunexpected\tO\nprolonged\tO\napnoea\tB-Disease\nlasting\tO\nseveral\tO\nhours\tO\nafter\tO\nsuccinylcholine\tB-Chemical\nhave\tO\nbeen\tO\ntreated\tO\nby\tO\na\tO\nnew\tO\npreparation\tO\nof\tO\nhuman\tO\nserum\tO\ncholinesterase\tO\n.\tO\n\nAdequate\tO\nspontaneous\tO\nrespiration\tO\nwas\tO\nre\tO\n-\tO\nestablished\tO\nin\tO\nan\tO\naverage\tO\nperiod\tO\nof\tO\nten\tO\nminutes\tO\nafter\tO\nthe\tO\ninjection\tO\n.\tO\n\nIn\tO\n12\tO\npatients\tO\nbiochemical\tO\ngenetic\tO\nexaminations\tO\nconfirmed\tO\nthe\tO\npresence\tO\nof\tO\nan\tO\natypical\tO\nserum\tO\ncholinesterase\tO\n.\tO\n\nIn\tO\nthree\tO\npatients\tO\nnone\tO\nof\tO\nthe\tO\nusual\tO\nvariants\tO\nwere\tO\nfound\tO\n.\tO\n\nIt\tO\nis\tO\ntherefore\tO\nsupposed\tO\nthat\tO\nother\tO\nunknown\tO\nvariants\tO\nof\tO\nserum\tO\ncholinesterase\tO\nexist\tO\nwhich\tO\ncannot\tO\nhydrolyze\tO\nsuccinylcholine\tB-Chemical\n.\tO\n\nThe\tO\nuse\tO\nof\tO\nserum\tO\ncholinesterase\tO\nin\tO\nsuccinylcholine\tB-Chemical\napnoea\tB-Disease\nprovided\tO\nconsiderable\tO\nrelief\tO\nto\tO\nboth\tO\npatient\tO\nand\tO\nanaesthetist\tO\n.\tO\n\nIncreased\tO\nsulfation\tO\nand\tO\ndecreased\tO\n7alpha\tO\n-\tO\nhydroxylation\tO\nof\tO\ndeoxycholic\tB-Chemical\nacid\tI-Chemical\nin\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n-\tO\ninduced\tO\ncholestasis\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nDeoxycholic\tB-Chemical\nacid\tI-Chemical\nconjugation\tO\n,\tO\ntransport\tO\ncapacity\tO\n,\tO\nand\tO\nmetabolism\tO\nwere\tO\ncompared\tO\nin\tO\ncontrol\tO\nand\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nControl\tO\nrats\tO\nwere\tO\nfound\tO\nto\tO\nhave\tO\na\tO\nlower\tO\ncapacity\tO\nto\tO\ntransport\tO\ndeoxycholic\tB-Chemical\nacid\tI-Chemical\nthan\tO\ntaurodeoxycholic\tB-Chemical\nacid\tI-Chemical\n,\tO\nand\tO\nboth\tO\nwere\tO\ndecreased\tO\nby\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\ntreatment\tO\n.\tO\n\nDuring\tO\n[\tO\n24\tO\n-\tO\n14C\tO\n]\tO\nsodium\tB-Chemical\ndeoxycholate\tI-Chemical\ninfusion\tO\n,\tO\n[\tO\n14C\tO\n]\tO\nbiliary\tO\nbile\tB-Chemical\nacid\tI-Chemical\nsecretion\tO\nincreased\tO\n,\tO\nbut\tO\nbile\tO\nflow\tO\ndid\tO\nnot\tO\nchange\tO\nsignificantly\tO\nin\tO\neither\tO\ncontrol\tO\nor\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nEthinyl\tB-Chemical\nestradiol\tI-Chemical\n-\tO\ntreated\tO\nanimals\tO\nexcreted\tO\nsignificantly\tO\nless\tO\n14C\tO\nas\tO\ntaurocholic\tB-Chemical\nacid\tI-Chemical\nthan\tO\ndid\tO\ncontrol\tO\nanimals\tO\n,\tO\nconsistent\tO\nwith\tO\nan\tO\nimpairment\tO\nof\tO\n7alpha\tO\n-\tO\nhydroxylation\tO\nof\tO\ntaurodeoxycholic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nEthinyl\tB-Chemical\nestradiol\tI-Chemical\ntreatment\tO\ndid\tO\nnot\tO\nimpair\tO\nconjugation\tO\nof\tO\ndeoxycholic\tB-Chemical\nacid\tI-Chemical\n,\tO\nbut\tO\ndid\tO\nresult\tO\nin\tO\nan\tO\nincrease\tO\nin\tO\nsulfation\tO\nof\tO\ntaurodeoxycholic\tB-Chemical\nacid\tI-Chemical\nfrom\tO\n1\tO\n.\tO\n5\tO\n%\tO\nin\tO\ncontrols\tO\nto\tO\nnearly\tO\n4\tO\n.\tO\n0\tO\n%\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nare\tO\nconsistent\tO\nwith\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\nrat\tO\nhas\tO\na\tO\npoorer\tO\ntolerance\tO\nfor\tO\ndeoxycholic\tB-Chemical\nacid\tI-Chemical\nthan\tO\ndo\tO\ncertain\tO\nother\tO\nspecies\tO\n.\tO\n\nFurthermore\tO\n,\tO\nthe\tO\nrat\tO\nconverts\tO\ndeoxycholic\tB-Chemical\nacid\tI-Chemical\n,\tO\na\tO\npoor\tO\ncholeretic\tO\n,\tO\nto\tO\ntaurocholic\tB-Chemical\nacid\tI-Chemical\n,\tO\na\tO\ngood\tO\ncholeretic\tO\n.\tO\n\nWhen\tO\nthis\tO\nconversion\tO\nis\tO\nimpaired\tO\nwith\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\ntreatment\tO\n,\tO\nsulfation\tO\nmay\tO\nbe\tO\nan\tO\nimportant\tO\nalternate\tO\npathway\tO\nfor\tO\nexcretion\tO\nof\tO\nthis\tO\npotentially\tO\nharmful\tO\nbile\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nInfluence\tO\nof\tO\ndiet\tO\nfree\tO\nof\tO\nNAD\tB-Chemical\n-\tO\nprecursors\tO\non\tO\nacetaminophen\tB-Chemical\nhepatotoxicity\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nRecently\tO\n,\tO\nwe\tO\ndemonstrated\tO\nthe\tO\nhepatoprotective\tO\neffects\tO\nof\tO\nnicotinic\tB-Chemical\nacid\tI-Chemical\namide\tI-Chemical\n,\tO\na\tO\nselective\tO\ninhibitor\tO\nof\tO\npoly\tB-Chemical\n(\tI-Chemical\nADP\tI-Chemical\n-\tI-Chemical\nribose\tI-Chemical\n)\tI-Chemical\npolymerase\tO\n(\tO\nPARP\tO\n;\tO\nEC\tO\n2\tO\n.\tO\n4\tO\n.\tO\n2\tO\n.\tO\n30\tO\n)\tO\non\tO\nmice\tO\nsuffering\tO\nfrom\tO\nacetaminophen\tB-Chemical\n(\tO\nAAP\tB-Chemical\n)\tO\n-\tO\nhepatitis\tB-Disease\n,\tO\nsuggesting\tO\nthat\tO\nthe\tO\nAAP\tB-Chemical\n-\tO\ninduced\tO\nliver\tB-Disease\ninjury\tI-Disease\ninvolves\tO\na\tO\nstep\tO\nwhich\tO\ndepends\tO\non\tO\nadenoribosylation\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\ninvestigates\tO\nthe\tO\neffects\tO\nof\tO\na\tO\ndiet\tO\nfree\tO\nof\tO\nprecursors\tO\nof\tO\nNAD\tB-Chemical\n,\tO\nthe\tO\nsubstrate\tO\non\tO\nwhich\tO\nPARP\tO\nacts\tO\n,\tO\nin\tO\nfemale\tO\nNMRI\tO\nmice\tO\nwith\tO\nAAP\tB-Chemical\nhepatitis\tB-Disease\nand\tO\nevaluates\tO\nthe\tO\ninfluence\tO\nof\tO\nsimultaneous\tO\nethanol\tB-Chemical\nconsumption\tO\nin\tO\nthese\tO\nanimals\tO\n.\tO\n\nLiver\tB-Disease\ninjuries\tI-Disease\nwere\tO\nquantified\tO\nas\tO\nserum\tO\nactivities\tO\nof\tO\nglutamate\tB-Chemical\n-\tO\noxaloacetate\tB-Chemical\ntransaminase\tO\n(\tO\nGOT\tO\n)\tO\nand\tO\nglutamate\tB-Chemical\n-\tO\npyruvate\tB-Chemical\ntransaminase\tO\n(\tO\nGPT\tO\n)\tO\n.\tO\n\nWhile\tO\nAAP\tB-Chemical\ncaused\tO\na\tO\n117\tO\n-\tO\nfold\tO\nelevation\tO\nof\tO\nserum\tO\ntransaminase\tO\nactivities\tO\nin\tO\nmice\tO\nkept\tO\non\tO\na\tO\nstandard\tO\nlaboratory\tO\ndiet\tO\n,\tO\nwhich\tO\nwas\tO\nsignificantly\tO\nexacerbated\tO\nby\tO\nethanol\tB-Chemical\nand\tO\ninhibited\tO\nby\tO\nnicotinic\tB-Chemical\nacid\tI-Chemical\namide\tI-Chemical\n(\tO\nNAA\tB-Chemical\n)\tO\n,\tO\nadverse\tO\neffects\tO\nwere\tO\nnoted\tO\nin\tO\nanimals\tO\nfed\tO\na\tO\ndiet\tO\nfree\tO\nof\tO\nprecursors\tO\nof\tO\nNAD\tB-Chemical\n.\tO\n\nIn\tO\nthese\tO\nanimals\tO\n,\tO\nonly\tO\nminor\tO\nincreases\tO\nof\tO\nserum\tO\ntransaminase\tO\nactivities\tO\nwere\tO\nmeasured\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nAAP\tB-Chemical\n,\tO\nand\tO\nunlike\tO\nthe\tO\nexacerbation\tO\ncaused\tO\nby\tO\nethanol\tB-Chemical\nin\tO\nmice\tO\non\tO\na\tO\nstandard\tO\ndiet\tO\n,\tO\nthe\tO\nliver\tB-Disease\ndamage\tI-Disease\nwas\tO\ninhibited\tO\nby\tO\n50\tO\n%\tO\nby\tO\nethanol\tB-Chemical\n.\tO\n\nA\tO\nfurther\tO\n64\tO\n%\tO\nreduction\tO\nof\tO\nhepatitis\tB-Disease\nwas\tO\nobserved\tO\n,\tO\nwhen\tO\nNAA\tB-Chemical\nwas\tO\ngiven\tO\nto\tO\nethanol\tB-Chemical\n/\tO\nAAP\tB-Chemical\n-\tO\nmice\tO\n.\tO\n\nOur\tO\nresults\tO\nprovide\tO\nevidence\tO\nthat\tO\nthe\tO\nAAP\tB-Chemical\n-\tO\ninduced\tO\nhepatitis\tB-Disease\nand\tO\nits\tO\nexacerbation\tO\nby\tO\nethanol\tB-Chemical\ncan\tO\neither\tO\nbe\tO\nreduced\tO\nby\tO\nend\tO\n-\tO\nproduct\tO\ninhibition\tO\nof\tO\nPARP\tO\nby\tO\nNAA\tB-Chemical\nor\tO\nby\tO\ndietary\tO\ndepletion\tO\nof\tO\nthe\tO\nenzyme\tO\n'\tO\ns\tO\nsubstrate\tO\nNAD\tB-Chemical\n.\tO\n\nWe\tO\nsee\tO\nthe\tO\nmain\tO\napplication\tO\nof\tO\nNAA\tB-Chemical\nas\tO\nfor\tO\nthe\tO\ncombinational\tO\nuse\tO\nin\tO\npharmaceutical\tO\npreparations\tO\nof\tO\nacetaminophen\tB-Chemical\nin\tO\norder\tO\nto\tO\navoid\tO\nhepatic\tB-Disease\ndamage\tI-Disease\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nthis\tO\nwidely\tO\nused\tO\nanalgesic\tO\n.\tO\n\nNightmares\tO\nand\tO\nhallucinations\tB-Disease\nafter\tO\nlong\tO\n-\tO\nterm\tO\nintake\tO\nof\tO\ntramadol\tB-Chemical\ncombined\tO\nwith\tO\nantidepressants\tO\n.\tO\n\nTramadol\tB-Chemical\nis\tO\na\tO\nweak\tO\nopioid\tO\nwith\tO\neffects\tO\non\tO\nadrenergic\tO\nand\tO\nserotonergic\tO\nneurotransmission\tO\nthat\tO\nis\tO\nused\tO\nto\tO\ntreat\tO\ncancer\tB-Disease\npain\tB-Disease\nand\tO\nchronic\tO\nnon\tO\nmalignant\tO\npain\tB-Disease\n.\tO\n\nThis\tO\ndrug\tO\nwas\tO\ninitiated\tO\nin\tO\nassociation\tO\nwith\tO\nparoxetine\tB-Chemical\nand\tO\ndosulepine\tB-Chemical\nhydrochloride\tI-Chemical\nin\tO\na\tO\ntetraparetic\tB-Disease\npatient\tO\nwith\tO\nchronic\tB-Disease\npain\tI-Disease\n.\tO\n\nFifty\tO\n-\tO\nsix\tO\ndays\tO\nafter\tO\ninitiation\tO\nof\tO\nthe\tO\ntreatment\tO\nthe\tO\npatient\tO\npresented\tO\nhallucinations\tB-Disease\nthat\tO\nonly\tO\nstopped\tO\nafter\tO\nthe\tO\nwithdrawal\tO\nof\tO\npsycho\tO\n-\tO\nactive\tO\ndrugs\tO\nand\tO\ntramadol\tB-Chemical\n.\tO\n\nThe\tO\ncase\tO\nreport\tO\nquestions\tO\nthe\tO\nlong\tO\nterm\tO\nuse\tO\nof\tO\npain\tB-Disease\nkillers\tO\ncombined\tO\nwith\tO\npsycho\tO\n-\tO\nactive\tO\ndrugs\tO\nin\tO\nchronic\tO\nnon\tO\nmalignant\tO\npain\tB-Disease\n,\tO\nespecially\tO\nif\tO\npain\tB-Disease\nis\tO\nunder\tO\ncontrol\tO\n.\tO\n\nEffect\tO\nof\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\nand\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\ntherapy\tO\non\tO\ndesipramine\tB-Chemical\ntoxicity\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nHypotension\tB-Disease\nis\tO\na\tO\nmajor\tO\ncontributor\tO\nto\tO\nmortality\tO\nin\tO\ntricyclic\tO\nantidepressant\tO\noverdose\tB-Disease\n.\tO\n\nRecent\tO\ndata\tO\nsuggest\tO\nthat\tO\ntricyclic\tO\nantidepressants\tO\ninhibit\tO\ncalcium\tB-Chemical\ninflux\tO\nin\tO\nsome\tO\ntissues\tO\n.\tO\n\nThis\tO\nstudy\tO\naddressed\tO\nthe\tO\npotential\tO\nrole\tO\nof\tO\ncalcium\tB-Chemical\nchannel\tO\nblockade\tO\nin\tO\ntricyclic\tO\nantidepressant\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nTwo\tO\ninterventions\tO\nwere\tO\nstudied\tO\nthat\tO\nhave\tO\nbeen\tO\nshown\tO\npreviously\tO\nto\tO\nimprove\tO\nblood\tO\npressure\tO\nwith\tO\ncalcium\tB-Chemical\nchannel\tO\nblocker\tO\noverdose\tB-Disease\n.\tO\n\nCaCl2\tB-Chemical\nand\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\n.\tO\n\nAnesthetized\tO\nrats\tO\nreceived\tO\nthe\tO\ntricyclic\tO\nantidepressant\tO\ndesipramine\tB-Chemical\nIP\tO\nto\tO\nproduce\tO\nhypotension\tB-Disease\n,\tO\nQRS\tO\nprolongation\tO\n,\tO\nand\tO\nbradycardia\tB-Disease\n.\tO\n\nFifteen\tO\nmin\tO\nlater\tO\n,\tO\nanimals\tO\nreceived\tO\nCaCl2\tB-Chemical\n,\tO\nNaHCO3\tB-Chemical\n,\tO\nor\tO\nsaline\tO\n.\tO\n\nIn\tO\na\tO\nsecond\tO\nexperiment\tO\n,\tO\nrats\tO\nreceived\tO\ntricyclic\tO\nantidepressant\tO\ndesipramine\tB-Chemical\nIP\tO\nfollowed\tO\nin\tO\n15\tO\nmin\tO\nby\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\nor\tO\nsaline\tO\n.\tO\n\nRESULTS\tO\n:\tO\nNaHCO3\tB-Chemical\nbriefly\tO\n(\tO\n5\tO\nmin\tO\n)\tO\nreversed\tO\nhypotension\tB-Disease\nand\tO\nQRS\tO\nprolongation\tO\n.\tO\n\nCaCl2\tB-Chemical\nand\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\nfailed\tO\nto\tO\nimprove\tO\nblood\tO\npressure\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n004\tO\n)\tO\nand\tO\nseizures\tB-Disease\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n03\tO\n)\tO\nin\tO\nthe\tO\nCaCl2\tB-Chemical\ngroup\tO\nwas\tO\nhigher\tO\nthan\tO\nthe\tO\nother\tO\ngroups\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nadministration\tO\nof\tO\nCaCl2\tB-Chemical\nor\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\ndid\tO\nnot\tO\nreverse\tO\ntricyclic\tO\nantidepressant\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nCaCl2\tB-Chemical\ntherapy\tO\nmay\tO\npossibly\tO\nworsen\tO\nboth\tO\ncardiovascular\tB-Disease\nand\tI-Disease\ncentral\tI-Disease\nnervous\tI-Disease\nsystem\tI-Disease\ntoxicity\tI-Disease\n.\tO\n\nThese\tO\nfindings\tO\ndo\tO\nnot\tO\nsupport\tO\na\tO\nrole\tO\nfor\tO\ncalcium\tB-Chemical\nchannel\tO\ninhibition\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\ntricyclic\tO\nantidepressant\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nValsartan\tB-Chemical\n,\tO\na\tO\nnew\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nantagonist\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nessential\tO\nhypertension\tB-Disease\n:\tO\na\tO\ncomparative\tO\nstudy\tO\nof\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nagainst\tO\namlodipine\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ncompare\tO\nthe\tO\nantihypertensive\tO\nefficacy\tO\nof\tO\na\tO\nnew\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nantagonist\tO\n,\tO\nvalsartan\tB-Chemical\n,\tO\nwith\tO\na\tO\nreference\tO\ntherapy\tO\n,\tO\namlodipine\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nOne\tO\nhundred\tO\nsixty\tO\n-\tO\neight\tO\nadult\tO\noutpatients\tO\nwith\tO\nmild\tO\nto\tO\nmoderate\tO\nhypertension\tB-Disease\nwere\tO\nrandomly\tO\nallocated\tO\nin\tO\ndouble\tO\n-\tO\nblind\tO\nfashion\tO\nand\tO\nequal\tO\nnumber\tO\nto\tO\nreceive\tO\n80\tO\nmg\tO\nvalsartan\tB-Chemical\nor\tO\n5\tO\nmg\tO\namlodipine\tB-Chemical\nfor\tO\n12\tO\nweeks\tO\n.\tO\n\nAfter\tO\n8\tO\nweeks\tO\nof\tO\ntherapy\tO\n,\tO\nin\tO\npatients\tO\nwhose\tO\nblood\tO\npressure\tO\nremained\tO\nuncontrolled\tO\n,\tO\n5\tO\nmg\tO\namlodipine\tB-Chemical\nwas\tO\nadded\tO\nto\tO\nthe\tO\ninitial\tO\ntherapy\tO\n.\tO\n\nPatients\tO\nwere\tO\nassessed\tO\nat\tO\n4\tO\n,\tO\n8\tO\n,\tO\nand\tO\n12\tO\nweeks\tO\n.\tO\n\nThe\tO\nprimary\tO\nefficacy\tO\nvariable\tO\nwas\tO\nchange\tO\nfrom\tO\nbaseline\tO\nin\tO\nmean\tO\nsitting\tO\ndiastolic\tO\nblood\tO\npressure\tO\nat\tO\n8\tO\nweeks\tO\n.\tO\n\nSecondary\tO\nvariables\tO\nincluded\tO\nchange\tO\nin\tO\nsitting\tO\nsystolic\tO\nblood\tO\npressure\tO\nand\tO\nresponder\tO\nrates\tO\n.\tO\n\nRESULTS\tO\n:\tO\nBoth\tO\nvalsartan\tB-Chemical\nand\tO\namlodipine\tB-Chemical\nwere\tO\neffective\tO\nat\tO\nlowering\tO\nblood\tO\npressure\tO\nat\tO\n4\tO\n,\tO\n8\tO\n,\tO\nand\tO\n12\tO\nweeks\tO\n.\tO\n\nSimilar\tO\ndecreases\tO\nwere\tO\nobserved\tO\nin\tO\nboth\tO\ngroups\tO\n,\tO\nwith\tO\nno\tO\nstatistically\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\nthe\tO\ngroups\tO\nfor\tO\nany\tO\nvariable\tO\nanalyzed\tO\n.\tO\n\nFor\tO\nthe\tO\nprimary\tO\nvariable\tO\nthe\tO\ndifference\tO\nwas\tO\n0\tO\n.\tO\n5\tO\nmm\tO\nHg\tO\nin\tO\nfavor\tO\nof\tO\nvalsartan\tB-Chemical\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n68\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n-\tO\n2\tO\n.\tO\n7\tO\nto\tO\n1\tO\n.\tO\n7\tO\n)\tO\n.\tO\n\nResponder\tO\nrates\tO\nat\tO\n8\tO\nweeks\tO\nwere\tO\n66\tO\n.\tO\n7\tO\n%\tO\nfor\tO\nvalsartan\tB-Chemical\nand\tO\n60\tO\n.\tO\n2\tO\n%\tO\nfor\tO\namlodipine\tB-Chemical\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n39\tO\n)\tO\n.\tO\n\nBoth\tO\ntreatments\tO\nwere\tO\nwell\tO\ntolerated\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ndrug\tO\n-\tO\nrelated\tO\ndependent\tO\nedema\tB-Disease\nwas\tO\nsomewhat\tO\nhigher\tO\nin\tO\nthe\tO\namlodipine\tB-Chemical\ngroup\tO\n,\tO\nparticularly\tO\nat\tO\na\tO\ndose\tO\nof\tO\n10\tO\nmg\tO\nper\tO\nday\tO\n(\tO\n2\tO\n.\tO\n4\tO\n%\tO\nfor\tO\n80\tO\nmg\tO\nvalsartan\tB-Chemical\n;\tO\n3\tO\n.\tO\n6\tO\n%\tO\nfor\tO\n5\tO\nmg\tO\namlodipine\tB-Chemical\n;\tO\n0\tO\n%\tO\nfor\tO\nvalsartan\tB-Chemical\nplus\tO\n5\tO\nmg\tO\namlodipine\tB-Chemical\n;\tO\n14\tO\n.\tO\n3\tO\n%\tO\nfor\tO\n10\tO\nmg\tO\namlodipine\tB-Chemical\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ndata\tO\nshow\tO\nthat\tO\nvalsartan\tB-Chemical\nis\tO\nat\tO\nleast\tO\nas\tO\neffective\tO\nas\tO\namlodipine\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nmild\tO\nto\tO\nmoderate\tO\nhypertension\tB-Disease\n.\tO\n\nThe\tO\nresults\tO\nalso\tO\nshow\tO\nvalsartan\tB-Chemical\nto\tO\nbe\tO\nwell\tO\ntolerated\tO\nand\tO\nsuggest\tO\nthat\tO\nit\tO\nis\tO\nnot\tO\nassociated\tO\nwith\tO\nside\tO\neffects\tO\ncharacteristic\tO\nof\tO\nthis\tO\ncomparator\tO\nclass\tO\n,\tO\ndihydropyridine\tB-Chemical\ncalcium\tB-Chemical\nantagonists\tO\n.\tO\n\nA\tO\nmeasure\tO\nof\tO\npupillary\tB-Disease\noscillation\tI-Disease\nas\tO\na\tO\nmarker\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nparanoia\tB-Disease\n.\tO\n\nCocaine\tB-Chemical\n-\tO\ninduced\tO\nparanoia\tB-Disease\n(\tO\nCIP\tB-Disease\n)\tO\nremains\tO\nan\tO\nimportant\tO\ndrug\tO\n-\tO\ninduced\tO\nmodel\tO\nof\tO\nidiopathic\tO\nparanoia\tB-Disease\nfor\tO\nwhich\tO\nno\tO\npsychophysiologic\tO\nmarker\tO\nhas\tO\nyet\tO\nemerged\tO\n.\tO\n\nMeasures\tO\nof\tO\npupillary\tB-Disease\noscillation\tI-Disease\nwere\tO\nable\tO\nto\tO\nsignificantly\tO\ndistinguish\tO\na\tO\ngroup\tO\nof\tO\nabstinent\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nabusers\tO\nendorsing\tO\npast\tO\nCIP\tB-Disease\n(\tO\nn\tO\n=\tO\n32\tO\n)\tO\nfrom\tO\nanother\tO\ngroup\tO\nof\tO\ncrack\tB-Chemical\naddicts\tO\nwho\tO\ndenied\tO\npast\tO\nCIP\tB-Disease\n(\tO\nn\tO\n=\tO\n29\tO\n)\tO\n.\tO\n\nSerotonin\tB-Disease\nsyndrome\tI-Disease\nfrom\tO\nvenlafaxine\tB-Chemical\n-\tO\ntranylcypromine\tB-Chemical\ninteraction\tO\n.\tO\n\nExcessive\tO\nstimulation\tO\nof\tO\nserotonin\tB-Chemical\n5HT1A\tO\nreceptors\tO\ncauses\tO\na\tO\nsyndrome\tO\nof\tO\nserotonin\tB-Chemical\nexcess\tO\nthat\tO\nconsists\tO\nof\tO\nshivering\tO\n,\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\n,\tO\nsalivation\tB-Disease\n,\tO\nconfusion\tB-Disease\n,\tO\nagitation\tB-Disease\nand\tO\nhyperthermia\tB-Disease\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\ncause\tO\nof\tO\nthis\tO\nsyndrome\tO\nis\tO\nan\tO\ninteraction\tO\nbetween\tO\na\tO\nmonoamine\tO\noxidase\tO\ninhibitor\tO\n(\tO\nMAOI\tO\n)\tO\nand\tO\na\tO\nspecific\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitor\tO\n.\tO\n\nVenlafaxine\tB-Chemical\nis\tO\na\tO\nnew\tO\nantidepressant\tO\nagent\tO\nthat\tO\ninhibits\tO\nthe\tO\nreuptake\tO\nof\tO\nserotonin\tB-Chemical\nand\tO\nnorepinephrine\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\nvenlafaxine\tB-Chemical\n-\tO\nMAOI\tO\ninteraction\tO\nthat\tO\nresulted\tO\nin\tO\nthe\tO\nserotonin\tB-Disease\nsyndrome\tI-Disease\nin\tO\na\tO\n23\tO\n-\tO\ny\tO\n-\tO\nold\tO\nmale\tO\nwho\tO\nwas\tO\ntaking\tO\ntranylcypromine\tB-Chemical\nfor\tO\ndepression\tB-Disease\n.\tO\n\nHe\tO\nhad\tO\nbeen\tO\nwell\tO\nuntil\tO\nthe\tO\nmorning\tO\nof\tO\npresentation\tO\nwhen\tO\nhe\tO\ntook\tO\n1\tO\n/\tO\n2\tO\ntab\tO\nof\tO\nvenlafaxine\tB-Chemical\n.\tO\n\nWithin\tO\n2\tO\nh\tO\nhe\tO\nbecame\tO\nconfused\tO\nwith\tO\njerking\tO\nmovements\tO\nof\tO\nhis\tO\nextremities\tO\n,\tO\ntremors\tB-Disease\nand\tO\nrigidity\tB-Disease\n.\tO\n\nHe\tO\nwas\tO\nbrought\tO\ndirectly\tO\nto\tO\na\tO\nhospital\tO\nwhere\tO\nhe\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\nagitated\tO\nand\tO\nconfused\tO\nwith\tO\nshivering\tO\n,\tO\nmyoclonic\tB-Disease\njerks\tI-Disease\n,\tO\nrigidity\tB-Disease\n,\tO\nsalivation\tB-Disease\nand\tO\ndiaphoresis\tO\n.\tO\n\nHis\tO\npupils\tO\nwere\tO\n7\tO\nmm\tO\nand\tO\nsluggishly\tO\nreactive\tO\nto\tO\nlight\tO\n.\tO\n\nVital\tO\nsigns\tO\nwere\tO\n:\tO\nblood\tO\npressure\tO\n120\tO\n/\tO\n67\tO\nmm\tO\nHg\tO\n,\tO\nheart\tO\nrate\tO\n127\tO\n/\tO\nmin\tO\n,\tO\nrespiratory\tO\nrate\tO\n28\tO\n/\tO\nmin\tO\n,\tO\nand\tO\ntemperature\tO\n97\tO\nF\tO\n.\tO\n\nAfter\tO\n180\tO\nmg\tO\nof\tO\ndiazepam\tB-Chemical\ni\tO\n.\tO\nv\tO\n.\tO\nhe\tO\nremained\tO\ntremulous\tO\nwith\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\nand\tO\nclenched\tO\njaws\tO\n.\tO\n\nHe\tO\nwas\tO\nintubated\tO\nfor\tO\nairway\tO\nprotection\tO\nand\tO\nbecause\tO\nof\tO\nhypoventilation\tB-Disease\n,\tO\nand\tO\nwas\tO\nparalyzed\tB-Disease\nto\tO\ncontrol\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\n.\tO\n\nHis\tO\nsubsequent\tO\ncourse\tO\nwas\tO\nremarkable\tO\nfor\tO\nnon\tO\n-\tO\nimmune\tO\nthrombocytopenia\tB-Disease\nwhich\tO\nresolved\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nmaximal\tO\ntemperature\tO\nwas\tO\n101\tO\n.\tO\n2\tO\nF\tO\nand\tO\nhis\tO\nCPK\tO\nremained\tO\n<\tO\n500\tO\nunits\tO\n/\tO\nL\tO\nwith\tO\nno\tO\nother\tO\nevidence\tO\nof\tO\nrhabdomyolysis\tB-Disease\n.\tO\n\nHis\tO\nmental\tO\nstatus\tO\nnormalized\tO\nand\tO\nhe\tO\nwas\tO\ntransferred\tO\nto\tO\na\tO\npsychiatry\tO\nward\tO\n.\tO\n\nThis\tO\npatient\tO\nsurvived\tO\nwithout\tO\nsequelae\tO\ndue\tO\nto\tO\nthe\tO\naggressive\tO\nsedation\tO\nand\tO\nneuromuscular\tO\nparalysis\tB-Disease\n.\tO\n\nCyclophosphamide\tB-Chemical\nassociated\tO\nbladder\tB-Disease\ncancer\tI-Disease\n-\tO\n-\tO\na\tO\nhighly\tO\naggressive\tO\ndisease\tO\n:\tO\nanalysis\tO\nof\tO\n12\tO\ncases\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nWe\tO\ngained\tO\nknowledge\tO\nof\tO\nthe\tO\netiology\tO\n,\tO\ntreatment\tO\nand\tO\nprevention\tO\nof\tO\ncyclophosphamide\tB-Chemical\nassociated\tO\nurothelial\tB-Disease\ncancer\tI-Disease\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nThe\tO\nmedical\tO\nrecords\tO\nof\tO\n6\tO\nmen\tO\nand\tO\n6\tO\nwomen\tO\n(\tO\nmean\tO\nage\tO\n55\tO\nyears\tO\n)\tO\nwith\tO\ncyclophosphamide\tB-Chemical\nassociated\tO\nbladder\tB-Disease\ncancer\tI-Disease\nwere\tO\nreviewed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\ntumors\tB-Disease\nwere\tO\ngrade\tO\n3\tO\nor\tO\n4\tO\ntransitional\tO\ncell\tO\ncarcinoma\tB-Disease\n.\tO\n\nOf\tO\nthe\tO\n5\tO\npatients\tO\ninitially\tO\ntreated\tO\nwith\tO\nendoscopic\tO\nresection\tO\nalone\tO\nonly\tO\n1\tO\nis\tO\nalive\tO\nwithout\tO\ndisease\tO\n.\tO\n\nOf\tO\nthe\tO\n6\tO\npatients\tO\nwho\tO\nunderwent\tO\nearly\tO\ncystectomy\tO\n4\tO\nwere\tO\nalive\tO\nat\tO\n24\tO\nto\tO\n111\tO\nmonths\tO\n.\tO\n\nThe\tO\nremaining\tO\npatient\tO\nwith\tO\nextensive\tO\ncancer\tB-Disease\nunderwent\tO\npartial\tO\ncystectomy\tO\nfor\tO\npalliation\tO\nand\tO\ndied\tO\n3\tO\nmonths\tO\nlater\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCyclophosphamide\tB-Chemical\nassociated\tO\nbladder\tB-Disease\ntumor\tI-Disease\nis\tO\nan\tO\naggressive\tO\ndisease\tO\n.\tO\n\nHowever\tO\n,\tO\nlong\tO\n-\tO\nterm\tO\nsurvival\tO\nis\tO\npossible\tO\nwhen\tO\nradical\tO\ncystectomy\tO\nis\tO\nperformed\tO\nfor\tO\nbladder\tB-Disease\ntumors\tI-Disease\nwith\tO\nany\tO\nsign\tO\nof\tO\ninvasion\tO\nand\tO\nfor\tO\nrecurrent\tO\nhigh\tO\ngrade\tO\ndisease\tO\n,\tO\neven\tO\nwhen\tO\nnoninvasive\tO\n.\tO\n\nA\tO\nphase\tO\nI\tO\nclinical\tO\nstudy\tO\nof\tO\nthe\tO\nantipurine\tB-Chemical\nantifolate\tO\nlometrexol\tB-Chemical\n(\tO\nDDATHF\tB-Chemical\n)\tO\ngiven\tO\nwith\tO\noral\tO\nfolic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nLometrexol\tB-Chemical\nis\tO\nan\tO\nantifolate\tO\nwhich\tO\ninhibits\tO\nglycinamide\tB-Chemical\nribonucleotide\tI-Chemical\nformyltransferase\tO\n(\tO\nGARFT\tO\n)\tO\n,\tO\nan\tO\nenzyme\tO\nessential\tO\nfor\tO\nde\tO\nnovo\tO\npurine\tB-Chemical\nsynthesis\tO\n.\tO\n\nExtensive\tO\nexperimental\tO\nand\tO\nlimited\tO\nclinical\tO\ndata\tO\nhave\tO\nshown\tO\nthat\tO\nlometrexol\tB-Chemical\nhas\tO\nactivity\tO\nagainst\tO\ntumours\tB-Disease\nwhich\tO\nare\tO\nrefractory\tO\nto\tO\nother\tO\ndrugs\tO\n,\tO\nnotably\tO\nmethotrexate\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\ninitial\tO\nclinical\tO\ndevelopment\tO\nof\tO\nlometrexol\tB-Chemical\nwas\tO\ncurtailed\tO\nbecause\tO\nof\tO\nsevere\tO\nand\tO\ncumulative\tO\nantiproliferative\tO\ntoxicities\tB-Disease\n.\tO\n\nPreclinical\tO\nmurine\tO\nstudies\tO\ndemonstrated\tO\nthat\tO\nthe\tO\ntoxicity\tB-Disease\nof\tO\nlometrexol\tB-Chemical\ncan\tO\nbe\tO\nprevented\tO\nby\tO\nlow\tO\ndose\tO\nfolic\tB-Chemical\nacid\tI-Chemical\nadministration\tO\n,\tO\ni\tO\n.\tO\ne\tO\n.\tO\nfor\tO\n7\tO\ndays\tO\nprior\tO\nto\tO\nand\tO\n7\tO\ndays\tO\nfollowing\tO\na\tO\nsingle\tO\nbolus\tO\ndose\tO\n.\tO\n\nThis\tO\nobservation\tO\nprompted\tO\na\tO\nPhase\tO\nI\tO\nclinical\tO\nstudy\tO\nof\tO\nlometrexol\tB-Chemical\ngiven\tO\nwith\tO\nfolic\tB-Chemical\nacid\tI-Chemical\nsupplementation\tO\nwhich\tO\nhas\tO\nconfirmed\tO\nthat\tO\nthe\tO\ntoxicity\tB-Disease\nof\tO\nlometrexol\tB-Chemical\ncan\tO\nbe\tO\nmarkedly\tO\nreduced\tO\nby\tO\nfolic\tB-Chemical\nacid\tI-Chemical\nsupplementation\tO\n.\tO\n\nThrombocytopenia\tB-Disease\nand\tO\nmucositis\tB-Disease\nwere\tO\nthe\tO\nmajor\tO\ntoxicities\tB-Disease\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nclear\tO\nrelationship\tO\nbetween\tO\nclinical\tO\ntoxicity\tB-Disease\nand\tO\nthe\tO\nextent\tO\nof\tO\nplasma\tO\nfolate\tB-Chemical\nelevation\tO\n.\tO\n\nAssociated\tO\nstudies\tO\ndemonstrated\tO\nthat\tO\nlometrexol\tB-Chemical\nplasma\tO\npharmacokinetics\tO\nwere\tO\nnot\tO\naltered\tO\nby\tO\nfolic\tB-Chemical\nacid\tI-Chemical\nadministration\tO\nindicating\tO\nthat\tO\nsupplementation\tO\nis\tO\nunlikely\tO\nto\tO\nreduce\tO\ntoxicity\tB-Disease\nby\tO\nenhancing\tO\nlometrexol\tB-Chemical\nplasma\tO\nclearance\tO\n.\tO\n\nThe\tO\nwork\tO\ndescribed\tO\nin\tO\nthis\tO\nreport\tO\nhas\tO\nidentified\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\na\tO\nclinically\tO\nacceptable\tO\nschedule\tO\nfor\tO\nthe\tO\nadministration\tO\nof\tO\na\tO\nGARFT\tO\ninhibitor\tO\n.\tO\n\nThis\tO\ninformation\tO\nwill\tO\nfacilitate\tO\nthe\tO\nfuture\tO\nevaluation\tO\nof\tO\nthis\tO\nclass\tO\nof\tO\ncompounds\tO\nin\tO\ncancer\tB-Disease\ntherapy\tO\n.\tO\n\nFatal\tO\nexcited\tO\ndelirium\tB-Disease\nfollowing\tO\ncocaine\tB-Chemical\nuse\tO\n:\tO\nepidemiologic\tO\nfindings\tO\nprovide\tO\nnew\tO\nevidence\tO\nfor\tO\nmechanisms\tO\nof\tO\ncocaine\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nWe\tO\ndescribe\tO\nan\tO\noutbreak\tO\nof\tO\ndeaths\tO\nfrom\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nexcited\tO\ndelirium\tB-Disease\n(\tO\nEDDs\tB-Disease\n)\tO\nin\tO\nDade\tO\nCounty\tO\n,\tO\nFlorida\tO\nbetween\tO\n1979\tO\nand\tO\n1990\tO\n.\tO\n\nFrom\tO\na\tO\nregistry\tO\nof\tO\nall\tO\ncocaine\tB-Chemical\n-\tO\nrelated\tO\ndeaths\tO\nin\tO\nDade\tO\nCounty\tO\n,\tO\nFlorida\tO\n,\tO\nfrom\tO\n1969\tO\n-\tO\n1990\tO\n,\tO\n58\tO\nEDDs\tB-Disease\nwere\tO\ncompared\tO\nwith\tO\n125\tO\nvictims\tO\nof\tO\naccidental\tO\ncocaine\tB-Chemical\noverdose\tB-Disease\nwithout\tO\nexcited\tO\ndelirium\tB-Disease\n.\tO\n\nCompared\tO\nwith\tO\ncontrols\tO\n,\tO\nEDDs\tB-Disease\nwere\tO\nmore\tO\nfrequently\tO\nblack\tO\n,\tO\nmale\tO\n,\tO\nand\tO\nyounger\tO\n.\tO\n\nThey\tO\nwere\tO\nless\tO\nlikely\tO\nto\tO\nhave\tO\na\tO\nlow\tO\nbody\tO\nmass\tO\nindex\tO\n,\tO\nand\tO\nmore\tO\nlikely\tO\nto\tO\nhave\tO\ndied\tO\nin\tO\npolice\tO\ncustody\tO\n,\tO\nto\tO\nhave\tO\nreceived\tO\nmedical\tO\ntreatment\tO\nimmediately\tO\nbefore\tO\ndeath\tO\n,\tO\nto\tO\nhave\tO\nsurvived\tO\nfor\tO\na\tO\nlonger\tO\nperiod\tO\n,\tO\nto\tO\nhave\tO\ndeveloped\tO\nhyperthermia\tB-Disease\n,\tO\nand\tO\nto\tO\nhave\tO\ndied\tO\nin\tO\nsummer\tO\nmonths\tO\n.\tO\n\nEDDs\tB-Disease\nhad\tO\nconcentrations\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\nbenzoylecgonine\tB-Chemical\nin\tO\nautopsy\tO\nblood\tO\nthat\tO\nwere\tO\nsimilar\tO\nto\tO\nthose\tO\nfor\tO\ncontrols\tO\n.\tO\n\nThe\tO\nepidemiologic\tO\nfindings\tO\nare\tO\nmost\tO\nconsistent\tO\nwith\tO\nthe\tO\nhypothesis\tO\nthat\tO\nchronic\tO\ncocaine\tB-Chemical\nuse\tO\ndisrupts\tO\ndopaminergic\tO\nfunction\tO\nand\tO\n,\tO\nwhen\tO\ncoupled\tO\nwith\tO\nrecent\tO\ncocaine\tB-Chemical\nuse\tO\n,\tO\nmay\tO\nprecipitate\tO\nagitation\tB-Disease\n,\tO\ndelirium\tB-Disease\n,\tO\naberrant\tO\nthermoregulation\tO\n,\tO\nrhabdomyolysis\tB-Disease\n,\tO\nand\tO\nsudden\tB-Disease\ndeath\tI-Disease\n.\tO\n\nPemoline\tB-Chemical\ninduced\tO\nacute\tO\nchoreoathetosis\tB-Disease\n:\tO\ncase\tO\nreport\tO\nand\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nPemoline\tB-Chemical\nis\tO\nan\tO\noxazolidine\tB-Chemical\nderivative\tO\nthat\tO\nis\tO\nstructurally\tO\ndifferent\tO\nfrom\tO\namphetamines\tB-Chemical\nand\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nattention\tB-Disease\ndeficit\tI-Disease\ndisorder\tI-Disease\n.\tO\n\nPemoline\tB-Chemical\nhas\tO\nnot\tO\nbeen\tO\ncommonly\tO\nassociated\tO\nin\tO\nthe\tO\nliterature\tO\nas\tO\na\tO\ncause\tO\nof\tO\nacute\tO\nmovement\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nThe\tO\nfollowing\tO\ncase\tO\ndescribes\tO\ntwo\tO\nchildren\tO\nacutely\tO\npoisoned\tO\nwith\tO\npemoline\tB-Chemical\nwho\tO\nexperienced\tO\nprofound\tO\nchoreoathetosis\tB-Disease\n.\tO\n\nCASE\tO\nREPORT\tO\n:\tO\nTwo\tO\n,\tO\n3\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\n,\tO\nidentical\tO\ntwin\tO\nsiblings\tO\npresented\tO\nto\tO\nthe\tO\nemergency\tO\ndepartment\tO\nafter\tO\nfound\tO\nplaying\tO\nwith\tO\na\tO\nan\tO\nempty\tO\nbottle\tO\nof\tO\npemoline\tB-Chemical\noriginally\tO\ncontaining\tO\n59\tO\ntablets\tO\n.\tO\n\nThe\tO\nchildren\tO\nhad\tO\na\tO\nmedical\tO\nhistory\tO\nsignificant\tO\nfor\tO\nattention\tB-Disease\ndeficit\tI-Disease\ndisorder\tI-Disease\npreviously\tO\ntreated\tO\nwith\tO\nmethylphenidate\tB-Chemical\nwithout\tO\nsuccess\tO\n.\tO\n\nThis\tO\nwas\tO\ntheir\tO\nfirst\tO\nday\tO\nof\tO\npemoline\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\nchoreoathetoid\tB-Disease\nmovements\tO\nbegan\tO\n45\tO\nmin\tO\nto\tO\n1\tO\nh\tO\nafter\tO\ningestion\tO\n.\tO\n\nThe\tO\nchildren\tO\ngave\tO\nno\tO\nhistory\tO\nof\tO\nprior\tO\nmovement\tB-Disease\ndisorders\tI-Disease\nand\tO\nthere\tO\nwas\tO\nno\tO\nfamily\tO\nhistory\tO\nof\tO\nmovement\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nThe\tO\nchildren\tO\nreceived\tO\ngastrointestinal\tO\ndecontamination\tO\nand\tO\nhigh\tO\ndoses\tO\nof\tO\nintravenous\tO\nbenzodiazepines\tB-Chemical\nin\tO\nan\tO\nattempt\tO\nto\tO\ncontrol\tO\nthe\tO\nchoreoathetoid\tB-Disease\nmovements\tO\n.\tO\n\nDespite\tO\ntreatment\tO\n,\tO\nthe\tO\nchildren\tO\ncontinued\tO\nto\tO\nhave\tO\nchoreoathetosis\tB-Disease\nfor\tO\napproximately\tO\n24\tO\nhours\tO\n.\tO\n\nForty\tO\n-\tO\neight\tO\nhours\tO\nafter\tO\nadmission\tO\n,\tO\nthe\tO\nchildren\tO\nappeared\tO\nto\tO\nbe\tO\nat\tO\ntheir\tO\nbaseline\tO\nand\tO\nwere\tO\ndischarged\tO\nhome\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nPemoline\tB-Chemical\nassociated\tO\nmovement\tB-Disease\ndisorder\tI-Disease\nhas\tO\nbeen\tO\nrarely\tO\nreported\tO\nin\tO\nthe\tO\nacute\tO\ntoxicology\tO\nliterature\tO\n.\tO\n\nThe\tO\npossibility\tO\nof\tO\nchoreoathetoid\tB-Disease\nmovements\tO\nshould\tO\nbe\tO\nconsidered\tO\nin\tO\npatients\tO\npresenting\tO\nafter\tO\npemoline\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nEffect\tO\nof\tO\nmyopic\tO\nexcimer\tO\nlaser\tO\nphotorefractive\tO\nkeratectomy\tO\non\tO\nthe\tO\nelectrophysiologic\tO\nfunction\tO\nof\tO\nthe\tO\nretina\tO\nand\tO\noptic\tO\nnerve\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nassess\tO\nby\tO\nelectrophysiologic\tO\ntesting\tO\nthe\tO\neffect\tO\nof\tO\nphotorefractive\tO\nkeratectomy\tO\n(\tO\nPRK\tO\n)\tO\non\tO\nthe\tO\nretina\tO\nand\tO\noptic\tO\nnerve\tO\n.\tO\n\nSETTING\tO\n:\tO\nEye\tO\nClinic\tO\n,\tO\nS\tO\n.\tO\n\nSalvatore\tO\nHospital\tO\n,\tO\nL\tO\n'\tO\nAquila\tO\nUniversity\tO\n,\tO\nItaly\tO\n.\tO\n\nMETHODS\tO\n:\tO\nStandard\tO\npattern\tO\nelectroretinograms\tO\n(\tO\nP\tO\n-\tO\nERGs\tO\n)\tO\nand\tO\nstandard\tO\npattern\tO\nvisual\tO\nevoked\tO\npotentials\tO\n(\tO\nP\tO\n-\tO\nVEPs\tO\n)\tO\nwere\tO\ndone\tO\nin\tO\n25\tO\neyes\tO\nof\tO\n25\tO\npatients\tO\nwho\tO\nhad\tO\nmyopic\tO\nPRK\tO\nfor\tO\nan\tO\nattempted\tO\ncorrection\tO\nbetween\tO\n5\tO\n.\tO\n00\tO\nand\tO\n15\tO\n.\tO\n00\tO\ndiopters\tO\n(\tO\nD\tO\n)\tO\n(\tO\nmean\tO\n8\tO\n.\tO\n00\tO\nD\tO\n)\tO\n.\tO\n\nTesting\tO\nwas\tO\ndone\tO\npreoperatively\tO\nand\tO\n3\tO\n,\tO\n6\tO\n,\tO\n12\tO\n,\tO\nand\tO\n18\tO\nmonths\tO\npostoperatively\tO\n.\tO\n\nThe\tO\ncontralateral\tO\neyes\tO\nserved\tO\nas\tO\ncontrols\tO\n.\tO\n\nDuring\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\n,\tO\n3\tO\npatients\tO\n(\tO\n12\tO\n%\tO\n)\tO\ndeveloped\tO\nsteroid\tB-Chemical\n-\tO\ninduced\tO\nelevated\tB-Disease\nintraocular\tI-Disease\npressure\tI-Disease\n(\tO\nIOP\tO\n)\tO\nthat\tO\nresolved\tO\nafter\tO\ncorticosteroid\tB-Chemical\ntherapy\tO\nwas\tO\ndiscontinued\tO\n.\tO\n\nRESULTS\tO\n:\tO\nNo\tO\nstatistically\tO\nsignificant\tO\ndifferences\tO\nwere\tO\nseen\tO\nbetween\tO\ntreated\tO\nand\tO\ncontrol\tO\neyes\tO\nnor\tO\nbetween\tO\ntreated\tO\neyes\tO\npreoperatively\tO\nand\tO\npostoperatively\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nMyopic\tO\nexcimer\tO\nlaser\tO\nPRK\tO\ndid\tO\nnot\tO\nseem\tO\nto\tO\naffect\tO\nthe\tO\nposterior\tO\nsegment\tO\n.\tO\n\nThe\tO\ntransient\tO\nsteroid\tB-Chemical\n-\tO\ninduced\tO\nIOP\tB-Disease\nrise\tI-Disease\ndid\tO\nnot\tO\nseem\tO\nto\tO\ncause\tO\nfunctional\tO\nimpairment\tO\n.\tO\n\nNeutrophil\tO\nsuperoxide\tB-Chemical\nand\tO\nhydrogen\tB-Chemical\nperoxide\tI-Chemical\nproduction\tO\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n.\tO\n\nDefects\tO\nin\tO\nsuperoxide\tB-Chemical\nand\tO\nhydrogen\tB-Chemical\nperoxide\tI-Chemical\nproduction\tO\nmay\tO\nbe\tO\nimplicated\tO\nin\tO\nthe\tO\nhigh\tO\nincidence\tO\nof\tO\nbacterial\tB-Disease\ninfections\tI-Disease\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n(\tO\nALF\tB-Disease\n)\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\noxygen\tB-Chemical\nradical\tO\nproduction\tO\nin\tO\npatients\tO\nwith\tO\nALF\tB-Disease\ndue\tO\nto\tO\nparacetamol\tB-Chemical\noverdose\tB-Disease\nwas\tO\ncompared\tO\nwith\tO\nthat\tO\nof\tO\nhealthy\tO\nvolunteers\tO\n.\tO\n\nNeutrophils\tO\nfrom\tO\n14\tO\nALF\tB-Disease\npatients\tO\nwere\tO\nstimulated\tO\nvia\tO\nthe\tO\ncomplement\tO\nreceptors\tO\nusing\tO\nzymosan\tO\nopsonized\tO\nwith\tO\nALF\tB-Disease\nor\tO\ncontrol\tO\nserum\tO\n.\tO\n\nSuperoxide\tB-Chemical\nand\tO\nhydrogen\tB-Chemical\nperoxide\tI-Chemical\nproduction\tO\nby\tO\nALF\tB-Disease\nneutrophils\tO\nstimulated\tO\nwith\tO\nzymosan\tO\nopsonized\tO\nwith\tO\nALF\tB-Disease\nserum\tO\nwas\tO\nsignificantly\tO\nreduced\tO\ncompared\tO\nwith\tO\nthe\tO\ncontrol\tO\nsubjects\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThis\tO\ndefect\tO\npersisted\tO\nwhen\tO\nzymosan\tO\nopsonized\tO\nby\tO\ncontrol\tO\nserum\tO\nwas\tO\nused\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nSuperoxide\tB-Chemical\nand\tO\nhydrogen\tB-Chemical\nperoxide\tI-Chemical\nproduction\tO\nin\tO\nneutrophils\tO\nstimulated\tO\nwith\tO\nformyl\tB-Chemical\n-\tI-Chemical\nmethionyl\tI-Chemical\n-\tI-Chemical\nleucyl\tI-Chemical\n-\tI-Chemical\nphenylalanine\tI-Chemical\n(\tO\nfMLP\tB-Chemical\n)\tO\nfrom\tO\na\tO\nfurther\tO\n18\tO\nALF\tB-Disease\npatients\tO\nwas\tO\nunaffected\tO\ncompared\tO\nwith\tO\ncontrol\tO\nneutrophils\tO\n.\tO\n\nSerum\tO\nC3\tO\ncomplement\tO\nlevels\tO\nwere\tO\nsignificantly\tO\nreduced\tO\nin\tO\nALF\tB-Disease\npatients\tO\ncompared\tO\nwith\tO\ncontrol\tO\nsubjects\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0005\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\ndemonstrate\tO\na\tO\nneutrophil\tO\ndefect\tO\nin\tO\nALF\tB-Disease\ndue\tO\nto\tO\nparacetamol\tB-Chemical\noverdose\tB-Disease\n,\tO\nthat\tO\nis\tO\ncomplement\tO\ndependent\tO\nbut\tO\nindependent\tO\nof\tO\nserum\tO\ncomplement\tO\n,\tO\npossibly\tO\nconnected\tO\nto\tO\nthe\tO\ncomplement\tO\nreceptor\tO\n.\tO\n\nCholesteryl\tB-Chemical\nhemisuccinate\tI-Chemical\ntreatment\tO\nprotects\tO\nrodents\tO\nfrom\tO\nthe\tO\ntoxic\tO\neffects\tO\nof\tO\nacetaminophen\tB-Chemical\n,\tO\nadriamycin\tB-Chemical\n,\tO\ncarbon\tB-Chemical\ntetrachloride\tI-Chemical\n,\tO\nchloroform\tB-Chemical\nand\tO\ngalactosamine\tB-Chemical\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nits\tO\nuse\tO\nas\tO\na\tO\nstabilizer\tO\n/\tO\nrigidifier\tO\nof\tO\nmembranes\tO\n,\tO\ncholesteryl\tB-Chemical\nhemisuccinate\tI-Chemical\n,\tO\ntris\tB-Chemical\nsalt\tI-Chemical\n(\tO\nCS\tB-Chemical\n)\tO\nadministration\tO\nhas\tO\nalso\tO\nbeen\tO\nshown\tO\nto\tO\nprotect\tO\nrats\tO\nfrom\tO\nthe\tO\nhepatotoxic\tB-Disease\neffects\tO\nof\tO\ncarbon\tB-Chemical\ntetrachloride\tI-Chemical\n(\tO\nCCl4\tB-Chemical\n)\tO\n.\tO\n\nTo\tO\nfurther\tO\nour\tO\nunderstanding\tO\nof\tO\nthe\tO\nmechanism\tO\nof\tO\nCS\tB-Chemical\ncytoprotection\tO\n,\tO\nwe\tO\nexamined\tO\nin\tO\nrats\tO\nand\tO\nmice\tO\nthe\tO\nprotective\tO\nabilities\tO\nof\tO\nCS\tB-Chemical\nand\tO\nthe\tO\nnon\tO\n-\tO\nhydrolyzable\tO\nether\tO\nform\tO\nof\tO\nCS\tB-Chemical\n,\tO\ngamma\tB-Chemical\n-\tI-Chemical\ncholesteryloxybutyric\tI-Chemical\nacid\tI-Chemical\n,\tO\ntris\tB-Chemical\nsalt\tI-Chemical\n(\tO\nCSE\tB-Chemical\n)\tO\nagainst\tO\nacetaminophen\tB-Chemical\n-\tO\n,\tO\nadriamycin\tB-Chemical\n-\tO\n,\tO\ncarbon\tB-Chemical\ntetrachloride\tI-Chemical\n-\tO\n,\tO\nchloroform\tB-Chemical\n-\tO\nand\tO\ngalactosamine\tB-Chemical\n-\tO\ninduced\tO\ntoxicity\tB-Disease\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthese\tO\nstudies\tO\ndemonstrated\tO\nthat\tO\nCS\tB-Chemical\n-\tO\nmediated\tO\nprotection\tO\nis\tO\nnot\tO\nselective\tO\nfor\tO\na\tO\nparticular\tO\nspecies\tO\n,\tO\norgan\tO\nsystem\tO\nor\tO\ntoxic\tO\nchemical\tO\n.\tO\n\nA\tO\n24\tO\n-\tO\nh\tO\npretreatment\tO\nof\tO\nboth\tO\nrats\tO\nand\tO\nmice\tO\nwith\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nCS\tB-Chemical\n(\tO\n100mg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\nresulted\tO\nin\tO\nsignificant\tO\nprotection\tO\nagainst\tO\nthe\tO\nhepatotoxic\tB-Disease\neffects\tO\nof\tO\nCCl4\tB-Chemical\n,\tO\nCHCl3\tB-Chemical\n,\tO\nacetaminophen\tB-Chemical\nand\tO\ngalactosamine\tB-Chemical\nand\tO\nagainst\tO\nthe\tO\nlethal\tO\n(\tO\nand\tO\npresumably\tO\ncardiotoxic\tB-Disease\n)\tO\neffect\tO\nof\tO\nadriamycin\tB-Chemical\nadministration\tO\n.\tO\n\nMaximal\tO\nCS\tB-Chemical\n-\tO\nmediated\tO\nprotection\tO\nwas\tO\nobserved\tO\nin\tO\nexperimental\tO\nanimals\tO\npretreated\tO\n24\tO\nh\tO\nprior\tO\nto\tO\nthe\tO\ntoxic\tO\ninsult\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\nCS\tB-Chemical\nintervenes\tO\nin\tO\na\tO\ncritical\tO\ncellular\tO\nevent\tO\nthat\tO\nis\tO\nan\tO\nimportant\tO\ncommon\tO\npathway\tO\nto\tO\ntoxic\tO\ncell\tO\ndeath\tO\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\nCS\tB-Chemical\nprotection\tO\ndoes\tO\nnot\tO\nappear\tO\nto\tO\nbe\tO\ndependent\tO\non\tO\nthe\tO\ninhibition\tO\nof\tO\nchemical\tO\nbioactivation\tO\nto\tO\na\tO\ntoxic\tO\nreactive\tO\nintermediate\tO\n(\tO\nin\tO\nlight\tO\nof\tO\nthe\tO\nprotection\tO\nobserved\tO\nagainst\tO\ngalactosamine\tB-Chemical\nhepatotoxicity\tB-Disease\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nbased\tO\non\tO\nthe\tO\ndata\tO\npresented\tO\n,\tO\nwe\tO\ncan\tO\nnot\tO\nexclude\tO\nthe\tO\npossibility\tO\nthat\tO\nCS\tB-Chemical\nadministration\tO\ninhibits\tO\nchemical\tO\nbioactivation\tO\n.\tO\n\nOur\tO\nfindings\tO\ndo\tO\nsuggest\tO\nthat\tO\nCS\tB-Chemical\n-\tO\nmediated\tO\nprotection\tO\nis\tO\ndependent\tO\non\tO\nthe\tO\naction\tO\nof\tO\nthe\tO\nintact\tO\nanionic\tO\nCS\tB-Chemical\nmolecule\tO\n(\tO\nnon\tO\n-\tO\nhydrolyzable\tO\nCSE\tB-Chemical\nwas\tO\nas\tO\nprotective\tO\nas\tO\nCS\tB-Chemical\n)\tO\n,\tO\nwhose\tO\nmechanism\tO\nhas\tO\nyet\tO\nto\tO\nbe\tO\ndefined\tO\n.\tO\n\nA\tO\nmurine\tO\nmodel\tO\nof\tO\nadenomyosis\tB-Disease\n:\tO\nthe\tO\neffects\tO\nof\tO\nhyperprolactinemia\tB-Disease\ninduced\tO\nby\tO\nfluoxetine\tB-Chemical\nhydrochloride\tI-Chemical\n,\tO\na\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitor\tO\n,\tO\non\tO\nadenomyosis\tB-Disease\ninduction\tO\nin\tO\nWistar\tO\nalbino\tO\nrats\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nwhether\tO\nfluoxetine\tB-Chemical\ngiven\tO\nto\tO\ncastrated\tO\nand\tO\nnoncastrated\tO\nrats\tO\ncaused\tO\nhyperprolactinemia\tB-Disease\nand\tO\nits\tO\neffects\tO\nwith\tO\nrespect\tO\nto\tO\nadenomyosis\tB-Disease\n.\tO\n\nDESIGN\tO\n:\tO\nFluoxetine\tB-Chemical\n,\tO\na\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitor\tO\n,\tO\nwas\tO\ngiven\tO\nto\tO\nWistar\tO\nAlbino\tO\nrats\tO\nfor\tO\n98\tO\ndays\tO\nto\tO\nproduce\tO\nhyperprolactinemia\tB-Disease\n.\tO\n\nThe\tO\ndrug\tO\nwas\tO\ngiven\tO\nto\tO\ntwo\tO\ngroups\tO\nconsisting\tO\nof\tO\ncastrated\tO\nand\tO\nnoncastrated\tO\nrats\tO\nand\tO\ncompared\tO\nto\tO\ntwo\tO\ngroups\tO\nof\tO\ncastrated\tO\nand\tO\nnoncastrated\tO\ncontrols\tO\n.\tO\n\nProlactin\tO\nlevels\tO\nwere\tO\nmeasured\tO\nand\tO\nthe\tO\nuteri\tO\nof\tO\nthe\tO\nrats\tO\nwere\tO\nremoved\tO\nfor\tO\nhistopathological\tO\nanalysis\tO\nat\tO\nthe\tO\nend\tO\nof\tO\n98\tO\ndays\tO\n.\tO\n\nSETTING\tO\n:\tO\nMarmara\tO\nUniversity\tO\nSchool\tO\nof\tO\nMedicine\tO\n,\tO\nDepartment\tO\nof\tO\nHistology\tO\nand\tO\nEmbryology\tO\n,\tO\nZeynep\tO\nKamil\tO\nWomen\tO\nand\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\n.\tO\n\nMAIN\tO\nOUTCOME\tO\nMEASURES\tO\n:\tO\nSerum\tO\nprolactin\tO\nlevels\tO\n,\tO\nuterine\tO\nhistopathology\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nprolactin\tO\nlevels\tO\nof\tO\ncastrated\tO\nand\tO\nnoncastrated\tO\ngroups\tO\ntreated\tO\nwith\tO\nfluoxetine\tB-Chemical\nwere\tO\nstatistically\tO\nsignificantly\tO\nhigher\tO\nwhen\tO\ncompared\tO\nto\tO\ntheir\tO\nrespective\tO\ncontrol\tO\ngroups\tO\n.\tO\n\nHistological\tO\nstudies\tO\nrevealed\tO\n11\tO\ncases\tO\nof\tO\nadenomyosis\tB-Disease\n,\tO\nall\tO\nwithin\tO\nthe\tO\nnoncastrated\tO\ngroup\tO\nreceiving\tO\nfluoxetine\tB-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nIt\tO\nwas\tO\nsuggested\tO\nthat\tO\nhigh\tO\nserum\tO\nprolactin\tO\nlevels\tO\ncause\tO\ndegeneration\tO\nof\tO\nmyometrial\tO\ncells\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\novarian\tO\nsteroids\tB-Chemical\nthat\tO\nresults\tO\nin\tO\na\tO\nmyometrial\tO\ninvasion\tO\nby\tO\nendometrial\tO\nstroma\tO\n.\tO\n\nThis\tO\ninvasion\tO\neventually\tO\nprogresses\tO\nto\tO\nadenomyosis\tB-Disease\n.\tO\n\nPostinfarction\tO\nventricular\tB-Disease\nseptal\tI-Disease\ndefect\tI-Disease\nassociated\tO\nwith\tO\nlong\tO\n-\tO\nterm\tO\nsteroid\tB-Chemical\ntherapy\tO\n.\tO\n\nTwo\tO\ncases\tO\nof\tO\npostinfarction\tO\nventricular\tB-Disease\nseptal\tI-Disease\nrupture\tI-Disease\nin\tO\npatients\tO\non\tO\nlong\tO\n-\tO\nterm\tO\nsteroid\tB-Chemical\ntherapy\tO\nare\tO\npresented\tO\nand\tO\nthe\tO\nfavourable\tO\noutcome\tO\nin\tO\nboth\tO\ncases\tO\ndescribed\tO\n.\tO\n\nA\tO\npossible\tO\nassociation\tO\nbetween\tO\nsteroid\tB-Chemical\ntherapy\tO\nand\tO\nsubsequent\tO\npostinfarction\tO\nseptal\tB-Disease\nrupture\tI-Disease\nis\tO\ndiscussed\tO\n.\tO\n\nNeuroactive\tO\nsteroids\tB-Chemical\nprotect\tO\nagainst\tO\npilocarpine\tB-Chemical\n-\tO\nand\tO\nkainic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nlimbic\tO\nseizures\tB-Disease\nand\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nin\tO\nmice\tO\n.\tO\n\nSeveral\tO\nstructurally\tO\nrelated\tO\nmetabolites\tO\nof\tO\nprogesterone\tB-Chemical\n(\tO\n3\tB-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\npregnane\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\nones\tI-Chemical\n)\tO\nand\tO\ndeoxycorticosterone\tB-Chemical\n(\tO\n3\tB-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\npregnane\tI-Chemical\n-\tI-Chemical\n21\tI-Chemical\n-\tI-Chemical\ndiol\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\nones\tI-Chemical\n)\tO\nand\tO\ntheir\tO\n3\tO\nbeta\tO\n-\tO\nepimers\tO\nwere\tO\nevaluated\tO\nfor\tO\nprotective\tO\nactivity\tO\nagainst\tO\npilocarpine\tB-Chemical\n-\tO\n,\tO\nkainic\tB-Chemical\nacid\tI-Chemical\n-\tO\nand\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nseizures\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nSteroids\tB-Chemical\nwith\tO\nthe\tO\n3\tO\n-\tO\nhydroxy\tO\ngroup\tO\nin\tO\nthe\tO\nalpha\tO\n-\tO\nposition\tO\nand\tO\n5\tO\n-\tO\nH\tO\nin\tO\nthe\tO\nalpha\tO\n-\tO\nor\tO\nbeta\tO\n-\tO\nconfigurations\tO\nwere\tO\nhighly\tO\neffective\tO\nin\tO\nprotecting\tO\nagainst\tO\npilocarpine\tB-Chemical\n(\tO\n416\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\n-\tO\ninduced\tO\nlimbic\tO\nmotor\tO\nseizures\tB-Disease\nand\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n(\tO\nED50\tO\nvalues\tO\n,\tO\n7\tO\n.\tO\n0\tO\n-\tO\n18\tO\n.\tO\n7\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nThe\tO\ncorresponding\tO\nepimers\tO\nwith\tO\nthe\tO\n3\tO\n-\tO\nhydroxy\tO\ngroup\tO\nin\tO\nthe\tO\nbeta\tO\n-\tO\nposition\tO\nwere\tO\nalso\tO\neffective\tO\nbut\tO\nless\tO\npotent\tO\n(\tO\nED50\tO\nvalues\tO\n,\tO\n33\tO\n.\tO\n8\tO\n-\tO\n63\tO\n.\tO\n5\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nAlthough\tO\nthe\tO\nneuroactive\tO\nsteroids\tB-Chemical\nwere\tO\nconsiderably\tO\nless\tO\npotent\tO\nthan\tO\nthe\tO\nbenzodiazepine\tB-Chemical\nclonazepam\tB-Chemical\nin\tO\nprotecting\tO\nagainst\tO\npilocarpine\tB-Chemical\nseizures\tB-Disease\n,\tO\nsteroids\tB-Chemical\nwith\tO\nthe\tO\n5\tO\nalpha\tO\n,\tO\n3\tO\nalpha\tO\n-\tO\nconfiguration\tO\nhad\tO\ncomparable\tO\nor\tO\nhigher\tO\nprotective\tO\nindex\tO\nvalues\tO\n(\tO\nTD50\tO\nfor\tO\nmotor\tO\nimpairment\tO\ndivided\tO\nby\tO\nED50\tO\nfor\tO\nseizure\tB-Disease\nprotection\tO\n)\tO\nthan\tO\nclonazepam\tB-Chemical\n,\tO\nindicating\tO\nthat\tO\nsome\tO\nneuroactive\tO\nsteroids\tB-Chemical\nmay\tO\nhave\tO\nlower\tO\nrelative\tO\ntoxicity\tB-Disease\n.\tO\n\nSteroids\tB-Chemical\nwith\tO\nthe\tO\n5\tO\nalpha\tO\n,\tO\n3\tO\nalpha\tO\n-\tO\nor\tO\n5\tO\nbeta\tO\n,\tO\n3\tO\nalpha\tO\n-\tO\nconfigurations\tO\nalso\tO\nproduced\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\ndelay\tO\nin\tO\nthe\tO\nonset\tO\nof\tO\nlimbic\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\nkainic\tB-Chemical\nacid\tI-Chemical\n(\tO\n32\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\n,\tO\nbut\tO\ndid\tO\nnot\tO\ncompletely\tO\nprotect\tO\nagainst\tO\nthe\tO\nseizures\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nwhen\tO\na\tO\nsecond\tO\ndose\tO\nof\tO\nthe\tO\nsteroid\tB-Chemical\nwas\tO\nadministered\tO\n1\tO\nhr\tO\nafter\tO\nthe\tO\nfirst\tO\ndose\tO\n,\tO\ncomplete\tO\nprotection\tO\nfrom\tO\nthe\tO\nkainic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nlimbic\tO\nseizures\tB-Disease\nand\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nwas\tO\nobtained\tO\n.\tO\n\nThe\tO\nsteroids\tB-Chemical\nalso\tO\ncaused\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\ndelay\tO\nin\tO\nNMDA\tB-Chemical\n(\tO\n257\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\n-\tO\ninduced\tO\nlethality\tO\n,\tO\nbut\tO\ndid\tO\nnot\tO\ncompletely\tO\nprotect\tO\nagainst\tO\nNMDA\tB-Chemical\nseizures\tB-Disease\nor\tO\nlethality\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nneuroactive\tO\nsteroids\tB-Chemical\nare\tO\nhighly\tO\neffective\tO\nin\tO\nprotecting\tO\nagainst\tO\npilocarpine\tB-Chemical\n-\tO\nand\tO\nkainic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nin\tO\nmice\tO\n,\tO\nand\tO\nmay\tO\nbe\tO\nof\tO\nutility\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nsome\tO\nforms\tO\nof\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nin\tO\nhumans\tO\n.\tO\n\nHepatic\tO\nand\tO\nextrahepatic\tO\nangiotensinogen\tO\ngene\tO\nexpression\tO\nin\tO\nrats\tO\nwith\tO\nacute\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nPlasma\tO\nconcentration\tO\nand\tO\nurine\tO\nexcretion\tO\nof\tO\nthe\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\nproteins\tO\nare\tO\naltered\tO\nin\tO\nrats\tO\nwith\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n(\tO\nNS\tB-Disease\n)\tO\n.\tO\n\nIn\tO\nthis\tO\nwork\tO\nthe\tO\nmessenger\tO\nribonucleic\tO\nacid\tO\n(\tO\nmRNA\tO\n)\tO\nlevels\tO\nof\tO\nangiotensinogen\tO\n(\tO\nAo\tO\n)\tO\nwere\tO\nanalyzed\tO\nwith\tO\nthe\tO\nslot\tO\n-\tO\nblot\tO\nhybridization\tO\ntechnique\tO\nin\tO\nliver\tO\nand\tO\nother\tO\nextrahepatic\tO\ntissues\tO\n:\tO\nkidney\tO\n,\tO\nheart\tO\n,\tO\nbrain\tO\n,\tO\nand\tO\nadrenal\tO\ngland\tO\nfrom\tO\ncontrol\tO\n,\tO\nnephrotic\tB-Disease\n,\tO\nand\tO\npair\tO\n-\tO\nfed\tO\n(\tO\nPF\tO\n)\tO\nrats\tO\n.\tO\n\nNS\tB-Disease\nwas\tO\ninduced\tO\nby\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\npuromycin\tB-Chemical\namino\tI-Chemical\n-\tI-Chemical\nnucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n)\tO\n.\tO\n\nAlthough\tO\na\tO\ngreat\tO\nurinary\tO\nexcretion\tO\nand\tO\nhalf\tO\n-\tO\nnormal\tO\nplasma\tO\nlevels\tO\nof\tO\nAo\tO\nwere\tO\nobserved\tO\non\tO\nday\tO\n6\tO\nafter\tO\nPAN\tB-Chemical\ninjection\tO\n,\tO\nwhen\tO\nNS\tB-Disease\nwas\tO\nclearly\tO\nestablished\tO\n,\tO\nhepatic\tO\nAo\tO\nmRNA\tO\nlevels\tO\ndid\tO\nnot\tO\nchange\tO\n.\tO\n\nFurthermore\tO\n,\tO\nthe\tO\nAo\tO\nmRNA\tO\nlevels\tO\ndid\tO\nnot\tO\nchange\tO\nin\tO\nany\tO\nof\tO\nthe\tO\nextrahepatic\tO\ntissues\tO\nstudied\tO\non\tO\nday\tO\n6\tO\n,\tO\nnor\tO\ndid\tO\nits\tO\nhepatic\tO\nlevels\tO\nat\tO\ndays\tO\n1\tO\n,\tO\n3\tO\n,\tO\n5\tO\n,\tO\nor\tO\n7\tO\nafter\tO\nPAN\tB-Chemical\ninjection\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\nthe\tO\nhepatic\tO\nand\tO\nextrahepatic\tO\nAo\tO\nmRNA\tO\nlevels\tO\nare\tO\nunaltered\tO\nduring\tO\nthe\tO\ndevelopment\tO\nof\tO\nthe\tO\nacute\tO\nNS\tB-Disease\ninduced\tO\nby\tO\nPAN\tB-Chemical\n.\tO\n\nNeuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nwith\tO\nrisperidone\tB-Chemical\n.\tO\n\nNeuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nis\tO\nthought\tO\nto\tO\nbe\tO\na\tO\nresult\tO\nof\tO\ndopamine\tB-Chemical\nD2\tO\nreceptor\tO\nblockade\tO\nin\tO\nthe\tO\nstriatum\tO\nof\tO\nthe\tO\nbasal\tO\nganglia\tO\n.\tO\n\nRisperidone\tB-Chemical\n,\tO\na\tO\nbenzisoxazole\tB-Chemical\nderivative\tO\nantipsychotic\tO\n,\tO\nhas\tO\nhigh\tO\nserotonin\tB-Chemical\n5\tO\n-\tO\nHT2\tO\nreceptor\tO\nblockade\tO\nand\tO\ndose\tO\n-\tO\nrelated\tO\nD2\tO\nreceptor\tO\nblockade\tO\n.\tO\n\nThe\tO\nhigh\tO\nratio\tO\nis\tO\nbelieved\tO\nto\tO\nimpart\tO\nthe\tO\nlow\tO\nfrequency\tO\nof\tO\nextrapyramidal\tB-Disease\nsymptoms\tI-Disease\nwith\tO\nrisperidone\tB-Chemical\nat\tO\nlow\tO\ndosages\tO\n.\tO\n\nWith\tO\nthis\tO\nlow\tO\nfrequency\tO\nof\tO\nextrapyramidal\tB-Disease\nsymptoms\tI-Disease\n,\tO\nit\tO\nwas\tO\nthought\tO\nthe\tO\nfrequency\tO\nof\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nmight\tO\nalso\tO\nbe\tO\nlowered\tO\n.\tO\n\nA\tO\n73\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\ndeveloped\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nafter\tO\nmonotherapy\tO\nwith\tO\nrisperidone\tB-Chemical\n.\tO\n\nThe\tO\nsyndrome\tO\nreversed\tO\nafter\tO\ndiscontinuing\tO\nrisperidone\tB-Chemical\nand\tO\nstarting\tO\ntreatment\tO\nwith\tO\ndantrolene\tB-Chemical\nand\tO\nbromocriptine\tB-Chemical\n.\tO\n\nIt\tO\nappears\tO\nthat\tO\nthe\tO\nprotection\tO\nfrom\tO\nextrapyramidal\tO\nside\tO\neffects\tO\nobserved\tO\nwith\tO\nrisperidone\tB-Chemical\ndoes\tO\nnot\tO\nensure\tO\nprotection\tO\nfrom\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\nattenuating\tO\neffect\tO\nof\tO\ncarteolol\tB-Chemical\nhydrochloride\tI-Chemical\n,\tO\na\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\nantagonist\tO\n,\tO\non\tO\nneuroleptic\tO\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nIt\tO\nis\tO\nknown\tO\nthat\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\nantagonists\tO\nare\tO\neffective\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nakathisia\tB-Disease\n,\tO\none\tO\nof\tO\nthe\tO\nextrapyramidal\tO\nside\tO\neffects\tO\nthat\tO\noccur\tO\nduring\tO\nneuroleptic\tO\ntreatment\tO\n.\tO\n\nNeuroleptic\tO\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n,\tO\na\tO\nmodel\tO\nof\tO\nneuroleptic\tO\n-\tO\ninduced\tO\nextrapyramidal\tO\nside\tO\neffects\tO\n,\tO\nwas\tO\nconsidered\tO\nsuitable\tO\nas\tO\na\tO\nmodel\tO\nfor\tO\npredicting\tO\nneuroleptic\tO\n-\tO\ninduced\tO\nakathisia\tB-Disease\nin\tO\nhumans\tO\n,\tO\nalthough\tO\nneuroleptic\tO\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nwas\tO\nnot\tO\nconsidered\tO\na\tO\nspecific\tO\ntest\tO\nfor\tO\nneuroleptic\tO\n-\tO\ninduced\tO\nakathisia\tB-Disease\n.\tO\n\nTherefore\tO\n,\tO\nthe\tO\neffects\tO\nof\tO\ncarteolol\tB-Chemical\n,\tO\na\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\nantagonist\tO\n,\tO\non\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nin\tO\nrats\tO\nwere\tO\nbehaviorally\tO\nstudied\tO\nand\tO\ncompared\tO\nwith\tO\nthose\tO\nof\tO\npropranolol\tB-Chemical\nand\tO\nbiperiden\tB-Chemical\n,\tO\na\tO\nmuscarinic\tO\nreceptor\tO\nantagonist\tO\n.\tO\n\nCarteolol\tB-Chemical\n,\tO\nas\tO\nwell\tO\nas\tO\npropranolol\tB-Chemical\nand\tO\nbiperiden\tB-Chemical\n,\tO\ninhibited\tO\nthe\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n.\tO\n\nThe\tO\ninhibitory\tO\neffect\tO\nof\tO\ncarteolol\tB-Chemical\nwas\tO\nalmost\tO\ncomparable\tO\nto\tO\nthat\tO\nof\tO\npropranolol\tB-Chemical\n,\tO\nbut\tO\nwas\tO\nweaker\tO\nthan\tO\nthat\tO\nof\tO\nbiperiden\tB-Chemical\n.\tO\n\nCarteolol\tB-Chemical\ndid\tO\nnot\tO\nevoke\tO\npostsynaptic\tO\ndopamine\tB-Chemical\nreceptor\tO\n-\tO\nstimulating\tO\nbehavioral\tO\nsigns\tO\nsuch\tO\nas\tO\nstereotypy\tO\nand\tO\nhyperlocomotion\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nCarteolol\tB-Chemical\ndid\tO\nnot\tO\nantagonize\tO\nthe\tO\ninhibitory\tO\neffects\tO\nof\tO\nhaloperidol\tB-Chemical\non\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nstereotypy\tO\nand\tO\nlocomotor\tO\nactivity\tO\nin\tO\nrats\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\ncarteolol\tB-Chemical\ndid\tO\nnot\tO\nevoke\tO\n5\tO\n-\tO\nHT1A\tO\nreceptor\tO\n-\tO\nstimulating\tO\nbehavioral\tO\nsigns\tO\nsuch\tO\nas\tO\nflat\tO\nbody\tO\nposture\tO\nand\tO\nforepaw\tO\ntreading\tO\nand\tO\ndid\tO\nnot\tO\ninhibit\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptophan\tI-Chemical\n-\tO\ninduced\tO\nhead\tO\ntwitch\tO\nin\tO\nrats\tO\n.\tO\n\nFinally\tO\n,\tO\ncarteolol\tB-Chemical\ndid\tO\nnot\tO\ninhibit\tO\nphysostigmine\tB-Chemical\n-\tO\ninduced\tO\nlethality\tO\nin\tO\nrats\tO\n.\tO\n\nThese\tO\nresults\tO\nstrongly\tO\nsuggest\tO\nthat\tO\ncarteolol\tB-Chemical\nimproves\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nvia\tO\nits\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\nantagonistic\tO\nactivity\tO\nand\tO\nis\tO\nexpected\tO\nto\tO\nbe\tO\neffective\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nakathisia\tB-Disease\nwithout\tO\nattenuating\tO\nneuroleptic\tO\n-\tO\ninduced\tO\nantipsychotic\tO\neffects\tO\ndue\tO\nto\tO\nits\tO\npostsynaptic\tO\ndopamine\tB-Chemical\nreceptor\tO\nantagonistic\tO\nactivity\tO\n.\tO\n\nGranulosa\tB-Disease\ncell\tI-Disease\ntumor\tI-Disease\nof\tI-Disease\nthe\tI-Disease\novary\tI-Disease\nassociated\tO\nwith\tO\nantecedent\tO\ntamoxifen\tB-Chemical\nuse\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIncreased\tO\nattention\tO\nhas\tO\nbeen\tO\nfocused\tO\nrecently\tO\non\tO\nthe\tO\nestrogenic\tO\neffects\tO\nof\tO\ntamoxifen\tB-Chemical\n.\tO\n\nReview\tO\nof\tO\nthe\tO\nliterature\tO\nreveals\tO\nan\tO\nassociation\tO\nbetween\tO\ntamoxifen\tB-Chemical\nuse\tO\nand\tO\ngynecologic\tO\ntumors\tB-Disease\n.\tO\n\nCASE\tO\n:\tO\nA\tO\n52\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npostmenopausal\tO\nwoman\tO\nwas\tO\ntreated\tO\nwith\tO\ntamoxifen\tB-Chemical\nfor\tO\nstage\tO\nII\tO\nestrogen\tB-Chemical\nreceptor\tO\n-\tO\npositive\tO\nbreast\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nHer\tO\naspartate\tB-Chemical\ntransaminase\tO\nand\tO\nalanine\tB-Chemical\ntransaminase\tO\nlevels\tO\nincrease\tO\nmarkedly\tO\nafter\tO\n6\tO\nmonths\tO\nof\tO\ntamoxifen\tB-Chemical\nuse\tO\n.\tO\n\nAfter\tO\nan\tO\nadditional\tO\n17\tO\nmonths\tO\nof\tO\nelevated\tO\nserum\tO\ntransaminases\tO\n,\tO\nthe\tO\npatient\tO\nwas\tO\nfound\tO\nto\tO\nhave\tO\na\tO\nstage\tO\nIc\tO\ngranulosa\tB-Disease\ncell\tI-Disease\ntumor\tI-Disease\nof\tI-Disease\nthe\tI-Disease\novary\tI-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nPatients\tO\nwith\tO\ntamoxifen\tB-Chemical\n-\tO\ninduced\tO\nliver\tB-Disease\ndysfunction\tI-Disease\nmay\tO\nbe\tO\nat\tO\nincreased\tO\nrisk\tO\nfor\tO\ngranulosa\tB-Disease\ncell\tI-Disease\ntumors\tI-Disease\nbecause\tO\nof\tO\nalterations\tO\nin\tO\ntamoxifen\tB-Chemical\nmetabolism\tO\n.\tO\n\nLifetime\tO\ntreatment\tO\nof\tO\nmice\tO\nwith\tO\nazidothymidine\tB-Chemical\n(\tO\nAZT\tB-Chemical\n)\tO\nproduces\tO\nmyelodysplasia\tB-Disease\n.\tO\n\nAZT\tB-Chemical\nhas\tO\ninduced\tO\na\tO\nmacrocytic\tB-Disease\nanemia\tI-Disease\nin\tO\nAIDS\tB-Disease\npatients\tO\non\tO\nlong\tO\nterm\tO\nAZT\tB-Chemical\ntherapy\tO\n.\tO\n\nIt\tO\nis\tO\ngenerally\tO\nassumed\tO\nthat\tO\nDNA\tO\nelongation\tO\nis\tO\nstopped\tO\nby\tO\nthe\tO\ninsertion\tO\nof\tO\nAZT\tB-Chemical\ninto\tO\nthe\tO\nchain\tO\nin\tO\nplace\tO\nof\tO\nthymidine\tB-Chemical\nthus\tO\npreventing\tO\nthe\tO\nphosphate\tB-Chemical\nhydroxyl\tO\nlinkages\tO\nand\tO\ntherefore\tO\nsuppresses\tO\nhemopoietic\tO\nprogenitor\tO\ncell\tO\nproliferation\tO\nin\tO\nan\tO\nearly\tO\nstage\tO\nof\tO\ndifferentiation\tO\n.\tO\n\nCBA\tO\n/\tO\nCa\tO\nmale\tO\nmice\tO\nstarted\tO\non\tO\nAZT\tB-Chemical\n0\tO\n.\tO\n75\tO\nmg\tO\n/\tO\nml\tO\nH2O\tO\nat\tO\n84\tO\ndays\tO\nof\tO\nage\tO\nand\tO\nkept\tO\non\tO\nit\tO\nfor\tO\n687\tO\ndays\tO\nwhen\tO\ndosage\tO\nreduced\tO\nto\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\nH2O\tO\nfor\tO\na\tO\ngroup\tO\n,\tO\nanother\tO\ngroup\tO\nremoved\tO\nfrom\tO\nAZT\tB-Chemical\nto\tO\nsee\tO\nrecovery\tO\n,\tO\nand\tO\nthird\tO\ngroup\tO\nremained\tO\non\tO\n0\tO\n.\tO\n75\tO\nmg\tO\n.\tO\n\nAt\tO\n687\tO\ndays\tO\nmice\tO\nthat\tO\nhad\tO\nbeen\tO\non\tO\n0\tO\n.\tO\n75\tO\nmg\tO\nhad\tO\naverage\tO\nplatelet\tO\ncounts\tO\nof\tO\n2\tO\n.\tO\n5\tO\nx\tO\n10\tO\n(\tO\n6\tO\n)\tO\n.\tO\n\nHistological\tO\nexamination\tO\non\tO\n9\tO\nof\tO\n10\tO\nmice\tO\nwith\tO\nsuch\tO\nthrombocytopenia\tB-Disease\nshowed\tO\nchanges\tO\ncompatible\tO\nwith\tO\nmyelodysplastic\tB-Disease\nsyndrome\tI-Disease\n(\tO\nMDS\tB-Disease\n)\tO\n.\tO\n\nA\tO\nvariety\tO\nof\tO\nhistological\tO\npatterns\tO\nwas\tO\nobserved\tO\n.\tO\n\nThere\tO\nwere\tO\ntwo\tO\ncases\tO\nof\tO\nhypocellular\tO\nmyelodysplasia\tB-Disease\n,\tO\ntwo\tO\ncases\tO\nof\tO\nhypersegmented\tO\nmyelodysplastic\tB-Disease\ngranulocytosis\tO\n,\tO\ntwo\tO\ncases\tO\nof\tO\nhypercellular\tO\nmarrow\tO\nwith\tO\nabnormal\tO\nmegakaryocytes\tO\nwith\tO\nbizarre\tO\nnuclei\tO\n,\tO\none\tO\ncase\tO\nof\tO\nmegakaryocytic\tO\nmyelosis\tO\nassociated\tO\nwith\tO\na\tO\nhyperplastic\tB-Disease\nmarrow\tI-Disease\n,\tO\ndysmyelopoiesis\tB-Disease\nand\tO\na\tO\nhypocellular\tB-Disease\nmarrow\tI-Disease\nand\tO\ntwo\tO\ncases\tO\nof\tO\nmyelodysplasia\tB-Disease\nwith\tO\ndyserythropoiesis\tB-Disease\n,\tO\nhemosiderosis\tB-Disease\nand\tO\na\tO\nhypocellular\tB-Disease\nmarrow\tI-Disease\n.\tO\n\nAbove\tO\nmentioned\tO\nAZT\tB-Chemical\nincorporation\tO\nmay\tO\nhave\tO\ninduced\tO\nan\tO\nineffective\tO\nhemopoiesis\tO\nin\tO\nthe\tO\nprimitive\tO\nhemopoietic\tO\nprogenitor\tO\ncells\tO\n,\tO\nwhich\tO\nis\tO\nknown\tO\nto\tO\nbe\tO\nseen\tO\ncommonly\tO\nin\tO\nthe\tO\nmyelodysplastic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nBiphasic\tO\nresponse\tO\nof\tO\nthe\tO\nSA\tO\nnode\tO\nof\tO\nthe\tO\ndog\tO\nheart\tO\nin\tO\nvivo\tO\nto\tO\nselective\tO\nadministration\tO\nof\tO\nketamine\tB-Chemical\n.\tO\n\nEffect\tO\nof\tO\nketamine\tB-Chemical\non\tO\nthe\tO\nSA\tO\nnode\tO\nof\tO\nthe\tO\ndog\tO\nheart\tO\nwas\tO\nstudied\tO\nin\tO\nvivo\tO\nusing\tO\na\tO\nselective\tO\nperfusion\tO\ntechnique\tO\nof\tO\nthe\tO\nSA\tO\nnode\tO\nartery\tO\n.\tO\n\nInjections\tO\nof\tO\nketamine\tB-Chemical\nin\tO\ndoses\tO\nfrom\tO\n100\tO\nmicrogram\tO\nto\tO\n3\tO\nmg\tO\ninto\tO\nthe\tO\nartery\tO\nproduced\tO\na\tO\ndepression\tB-Disease\nof\tO\nthe\tO\nSA\tO\nnodal\tO\nactivity\tO\nby\tO\na\tO\ndirect\tO\naction\tO\n.\tO\n\nThis\tO\ndepression\tB-Disease\nwas\tO\nfollowed\tO\nby\tO\nthe\tO\nsudden\tO\nappearance\tO\nof\tO\na\tO\nstimulatory\tO\nphase\tO\n.\tO\n\nBilateral\tO\nvagotomy\tO\nand\tO\nsympathectomy\tO\nor\tO\nprior\tO\nadministration\tO\nof\tO\na\tO\nganglion\tO\nblocker\tO\nfailed\tO\nto\tO\ninhibit\tO\nthe\tO\noccurrence\tO\nof\tO\nthe\tO\nketamine\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\n,\tO\nwhile\tO\nit\tO\nwas\tO\ncompletely\tO\nabolished\tO\nin\tO\nthe\tO\nreserpinized\tO\ndogs\tO\nor\tO\nby\tO\na\tO\nprior\tO\ninjection\tO\nof\tO\na\tO\nbeta\tO\n-\tO\nblocking\tO\nagent\tO\ninto\tO\nthe\tO\nSA\tO\nnode\tO\nartery\tO\n.\tO\n\nThis\tO\nmay\tO\nindicate\tO\nthat\tO\nan\tO\nactivation\tO\nof\tO\nthe\tO\nperipheral\tO\nadrenergic\tO\nmechanism\tO\nplays\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\ninduction\tO\nof\tO\nthe\tO\nexcitatory\tO\neffect\tO\nof\tO\nketamine\tB-Chemical\ninjected\tO\nin\tO\nthe\tO\nSA\tO\nnode\tO\nartery\tO\n.\tO\n\nOver\tO\nexpression\tO\nof\tO\nvascular\tO\nendothelial\tO\ngrowth\tO\nfactor\tO\nand\tO\nits\tO\nreceptor\tO\nduring\tO\nthe\tO\ndevelopment\tO\nof\tO\nestrogen\tB-Chemical\n-\tO\ninduced\tO\nrat\tO\npituitary\tB-Disease\ntumors\tI-Disease\nmay\tO\nmediate\tO\nestrogen\tB-Chemical\n-\tO\ninitiated\tO\ntumor\tB-Disease\nangiogenesis\tO\n.\tO\n\nEstrogens\tB-Chemical\n,\tO\nwhich\tO\nhave\tO\nbeen\tO\nassociated\tO\nwith\tO\nseveral\tO\ntypes\tO\nof\tO\nhuman\tO\nand\tO\nanimal\tO\ncancers\tB-Disease\n,\tO\ncan\tO\ninduce\tO\ntumor\tB-Disease\nangiogenesis\tO\nin\tO\nthe\tO\npituitary\tO\nof\tO\nFischer\tO\n344\tO\nrats\tO\n.\tO\n\nThe\tO\nmechanistic\tO\ndetails\tO\nof\tO\ntumor\tB-Disease\nangiogenesis\tO\ninduction\tO\n,\tO\nduring\tO\nestrogen\tB-Chemical\ncarcinogenesis\tB-Disease\n,\tO\nare\tO\nstill\tO\nunknown\tO\n.\tO\n\nTo\tO\nelucidate\tO\nthe\tO\nrole\tO\nof\tO\nestrogen\tB-Chemical\nin\tO\nthe\tO\nregulation\tO\nof\tO\ntumor\tB-Disease\nangiogenesis\tO\nin\tO\nthe\tO\npituitary\tO\nof\tO\nfemale\tO\nrats\tO\n,\tO\nthe\tO\ndensity\tO\nof\tO\nblood\tO\nvessels\tO\nwas\tO\nanalysed\tO\nusing\tO\nfactor\tO\nVIII\tO\nrelated\tO\nantigen\tO\n(\tO\nFVIIIRAg\tO\n)\tO\nimmunohistochemistry\tO\nand\tO\nthe\tO\nexpression\tO\nof\tO\nvascular\tO\nendothelial\tO\ngrowth\tO\nfactor\tO\n/\tO\nvascular\tO\npermeability\tO\nfactor\tO\n(\tO\nVEGF\tO\n/\tO\nVPF\tO\n)\tO\nwas\tO\nexamined\tO\nby\tO\nWestern\tO\nblot\tO\nand\tO\nimmunohistochemical\tO\nanalysis\tO\n.\tO\n\nThe\tO\nexpression\tO\nof\tO\nVEGF\tO\nreceptor\tO\n(\tO\nVEGFR\tO\n-\tO\n2\tO\n/\tO\nFlk\tO\n-\tO\n1\tO\n/\tO\nKDR\tO\n)\tO\nwas\tO\nalso\tO\nexamined\tO\nby\tO\nimmunohistochemistry\tO\n.\tO\n\nThe\tO\nresults\tO\ndemonstrated\tO\nthat\tO\n17beta\tB-Chemical\n-\tI-Chemical\nestradiol\tI-Chemical\n(\tO\nE2\tB-Chemical\n)\tO\ninduces\tO\nneovascularization\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\ngrowth\tO\nand\tO\nenlargement\tO\nof\tO\nblood\tO\nvessels\tO\nafter\tO\n7\tO\ndays\tO\nof\tO\nexposure\tO\n.\tO\n\nThe\tO\nhigh\tO\ntumor\tB-Disease\nangiogenic\tO\npotential\tO\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nelevated\tO\nVEGF\tO\n/\tO\nVPF\tO\nprotein\tO\nexpression\tO\nin\tO\nthe\tO\nE2\tB-Chemical\nexposed\tO\npituitary\tO\nof\tO\novariectomized\tO\n(\tO\nOVEX\tO\n)\tO\nrats\tO\n.\tO\n\nVEGF\tO\n/\tO\nVPF\tO\nand\tO\nFVIIIRAg\tO\nimmunohistochemistry\tO\nand\tO\nendothelial\tO\nspecific\tO\nlectin\tO\n(\tO\nUEA1\tO\n)\tO\nbinding\tO\nstudies\tO\n,\tO\nindicate\tO\nthat\tO\nthe\tO\nelevation\tO\nof\tO\nVEGF\tO\nprotein\tO\nexpression\tO\ninitially\tO\noccurred\tO\nin\tO\nboth\tO\nblood\tO\nvessels\tO\nand\tO\nnon\tO\n-\tO\nendothelial\tO\ncells\tO\n.\tO\n\nAfter\tO\n15\tO\ndays\tO\nof\tO\nE2\tB-Chemical\nexposure\tO\n,\tO\nVEGF\tO\n/\tO\nVPF\tO\nprotein\tO\nexpression\tO\n,\tO\nin\tO\nthe\tO\nnon\tO\n-\tO\nendothelial\tO\ncell\tO\npopulation\tO\n,\tO\nsharply\tO\ndeclined\tO\nand\tO\nwas\tO\nrestricted\tO\nto\tO\nthe\tO\nblood\tO\nvessels\tO\n.\tO\n\nThe\tO\nfunction\tO\nof\tO\nnon\tO\n-\tO\nendothelial\tO\n-\tO\nderived\tO\nVEGF\tO\nis\tO\nnot\tO\nclear\tO\n.\tO\n\nFurthermore\tO\n,\tO\nimmunohistochemical\tO\nstudies\tO\ndemonstrated\tO\nthat\tO\nVEGFR\tO\n-\tO\n2\tO\n(\tO\nflk\tO\n-\tO\n1\tO\n/\tO\nKDR\tO\n)\tO\n,\tO\nexpression\tO\nwas\tO\nelevated\tO\nsignificantly\tO\nin\tO\nthe\tO\nendothelial\tO\ncells\tO\nof\tO\nmicroblood\tO\nvessels\tO\nafter\tO\n7\tO\ndays\tO\nof\tO\nE2\tB-Chemical\nexposure\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nover\tO\nexpression\tO\nof\tO\nVEGF\tO\nand\tO\nits\tO\nreceptor\tO\n(\tO\nVEGFR\tO\n-\tO\n2\tO\n)\tO\nmay\tO\nplay\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\ninitial\tO\nstep\tO\nof\tO\nthe\tO\nregulation\tO\nof\tO\nestrogen\tB-Chemical\ninduced\tO\ntumor\tB-Disease\nangiogenesis\tO\nin\tO\nthe\tO\nrat\tO\npituitary\tO\n.\tO\n\nPersistent\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\nfollowing\tO\nlithium\tB-Chemical\ntherapy\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\npatient\tO\nwho\tO\ndeveloped\tO\nsevere\tO\nhypernatraemic\tO\ndehydration\tB-Disease\nfollowing\tO\na\tO\nhead\tB-Disease\ninjury\tI-Disease\n.\tO\n\nTen\tO\nyears\tO\npreviously\tO\nhe\tO\nhad\tO\nbeen\tO\ndiagnosed\tO\nto\tO\nhave\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\n,\tO\nand\tO\nlithium\tB-Chemical\ntherapy\tO\nhad\tO\nbeen\tO\ndiscontinued\tO\n.\tO\n\nHe\tO\nremained\tO\nthirsty\tO\nand\tO\npolyuric\tB-Disease\ndespite\tO\ncessation\tO\nof\tO\nlithium\tB-Chemical\nand\tO\ninvestigations\tO\non\tO\nadmission\tO\nshowed\tO\nhim\tO\nto\tO\nhave\tO\nnormal\tO\nosmoregulated\tO\nthirst\tO\nand\tO\nvasopressin\tB-Chemical\nsecretion\tO\n,\tO\nwith\tO\nclear\tO\nevidence\tO\nof\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\n.\tO\n\nLithium\tB-Chemical\ninduced\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\nis\tO\nconsidered\tO\nto\tO\nbe\tO\nreversible\tO\non\tO\ncessation\tO\nof\tO\ntherapy\tO\nbut\tO\npolyuria\tB-Disease\npersisted\tO\nin\tO\nthis\tO\npatient\tO\nfor\tO\nten\tO\nyears\tO\nafter\tO\nlithium\tB-Chemical\nwas\tO\nstopped\tO\n.\tO\n\nWe\tO\ndiscuss\tO\nthe\tO\npossible\tO\nrenal\tO\nmechanisms\tO\nand\tO\nthe\tO\nimplications\tO\nfor\tO\nmanagement\tO\nof\tO\npatients\tO\nwith\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\n.\tO\n\nEffects\tO\nof\tO\nNIK\tB-Chemical\n-\tI-Chemical\n247\tI-Chemical\non\tO\ncholinesterase\tO\nand\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nNIK\tB-Chemical\n-\tI-Chemical\n247\tI-Chemical\non\tO\ncholinesterase\tO\n,\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\nand\tO\nspontaneous\tO\nmovement\tO\nwere\tO\nexamined\tO\nand\tO\ncompared\tO\nwith\tO\nthose\tO\nof\tO\nthe\tO\nwell\tO\n-\tO\nknown\tO\ncholinesterase\tO\ninhibitors\tO\ntacrine\tB-Chemical\nand\tO\nE\tB-Chemical\n-\tI-Chemical\n2020\tI-Chemical\n.\tO\n\nNIK\tB-Chemical\n-\tI-Chemical\n247\tI-Chemical\n,\tO\ntacrine\tB-Chemical\nand\tO\nE\tB-Chemical\n-\tI-Chemical\n2020\tI-Chemical\nall\tO\nstrongly\tO\ninhibited\tO\nacetylcholinesterase\tO\n(\tO\nAChE\tO\n)\tO\nin\tO\nhuman\tO\nred\tO\nblood\tO\ncells\tO\n(\tO\nIC50s\tO\n=\tO\n1\tO\n.\tO\n0\tO\nx\tO\n10\tO\n(\tO\n-\tO\n6\tO\n)\tO\n,\tO\n2\tO\n.\tO\n9\tO\nx\tO\n10\tO\n(\tO\n-\tO\n7\tO\n)\tO\nand\tO\n3\tO\n.\tO\n7\tO\nx\tO\n10\tO\n(\tO\n-\tO\n8\tO\n)\tO\nM\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nNIK\tB-Chemical\n-\tI-Chemical\n247\tI-Chemical\nand\tO\ntacrine\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nE\tB-Chemical\n-\tI-Chemical\n2020\tI-Chemical\n,\tO\nstrongly\tO\ninhibited\tO\nbutyrylcholinestrase\tO\n(\tO\nBuChE\tO\n)\tO\nin\tO\nhuman\tO\nserum\tO\n.\tO\n\nAll\tO\nthree\tO\ndrugs\tO\nproduced\tO\nmixed\tO\ninhibition\tO\nof\tO\nAChE\tO\nactivity\tO\n.\tO\n\nMoreover\tO\n,\tO\nthe\tO\ninhibitory\tO\neffect\tO\nof\tO\nNIK\tB-Chemical\n-\tI-Chemical\n247\tI-Chemical\non\tO\nAChE\tO\nwas\tO\nreversible\tO\n.\tO\n\nAll\tO\ncompounds\tO\nat\tO\n0\tO\n.\tO\n1\tO\n-\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\nsignificantly\tO\nimproved\tO\nthe\tO\namnesia\tB-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nin\tO\nrats\tO\nperforming\tO\na\tO\npassive\tO\navoidance\tO\ntask\tO\n.\tO\n\nThe\tO\nthree\tO\ncompounds\tO\nat\tO\n1\tO\nand\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\ndid\tO\nnot\tO\nsignificantly\tO\ndecrease\tO\nspontaneous\tO\nmovement\tO\nby\tO\nrats\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nNIK\tB-Chemical\n-\tI-Chemical\n247\tI-Chemical\nat\tO\na\tO\nlow\tO\ndose\tO\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\nimproves\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\nbut\tO\ndoes\tO\nnot\tO\naffect\tO\nspontaneous\tO\nmovement\tO\n.\tO\n\nThe\tO\nfindings\tO\nsuggest\tO\nthat\tO\nNIK\tB-Chemical\n-\tI-Chemical\n247\tI-Chemical\nmay\tO\nbe\tO\na\tO\nuseful\tO\ndrug\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nPotential\tO\ntherapeutic\tO\nuse\tO\nof\tO\nthe\tO\nselective\tO\ndopamine\tB-Chemical\nD1\tO\nreceptor\tO\nagonist\tO\n,\tO\nA\tB-Chemical\n-\tI-Chemical\n86929\tI-Chemical\n:\tO\nan\tO\nacute\tO\nstudy\tO\nin\tO\nparkinsonian\tB-Disease\nlevodopa\tB-Chemical\n-\tO\nprimed\tO\nmonkeys\tO\n.\tO\n\nThe\tO\nclinical\tO\nutility\tO\nof\tO\ndopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\nD1\tO\nreceptor\tO\nagonists\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\nis\tO\nstill\tO\nunclear\tO\n.\tO\n\nThe\tO\ntherapeutic\tO\nuse\tO\nof\tO\nselective\tO\nDA\tB-Chemical\nD1\tO\nreceptor\tO\nagonists\tO\nsuch\tO\nas\tO\nSKF\tB-Chemical\n-\tI-Chemical\n82958\tI-Chemical\n(\tO\n6\tB-Chemical\n-\tI-Chemical\nchloro\tI-Chemical\n-\tI-Chemical\n7\tI-Chemical\n,\tI-Chemical\n8\tI-Chemical\n-\tI-Chemical\ndihydroxy\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nallyl\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nphenyl\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\ntetrahydro\tI-Chemical\n-\tI-Chemical\n1H\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nbenzaze\tI-Chemical\npine\tI-Chemical\nhydrobromide\tI-Chemical\n)\tO\nand\tO\nA\tB-Chemical\n-\tI-Chemical\n77636\tI-Chemical\n(\tO\n[\tB-Chemical\n1R\tI-Chemical\n,\tI-Chemical\n3S\tI-Chemical\n]\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n1\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\nadmantyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\naminomethyl\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndihydro\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n,\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\ndihydroxy\tI-Chemical\n-\tI-Chemical\n1H\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nbenzo\tI-Chemical\npyran\tI-Chemical\nhydrochloride\tI-Chemical\n)\tO\nseems\tO\nlimited\tO\nbecause\tO\nof\tO\ntheir\tO\nduration\tO\nof\tO\naction\tO\n,\tO\nwhich\tO\nis\tO\ntoo\tO\nshort\tO\nfor\tO\nSKF\tB-Chemical\n-\tI-Chemical\n82958\tI-Chemical\n(\tO\n<\tO\n1\tO\nhr\tO\n)\tO\nand\tO\ntoo\tO\nlong\tO\nfor\tO\nA\tB-Chemical\n-\tI-Chemical\n77636\tI-Chemical\n(\tO\n>\tO\n20\tO\nhr\tO\n,\tO\nleading\tO\nto\tO\nbehavioral\tO\ntolerance\tO\n)\tO\n.\tO\n\nWe\tO\ntherefore\tO\nconducted\tO\nthe\tO\npresent\tO\nacute\tO\ndose\tO\n-\tO\nresponse\tO\nstudy\tO\nin\tO\nfour\tO\n1\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nphenyl\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\ntetrahydropyridine\tI-Chemical\n(\tO\nMPTP\tB-Chemical\n)\tO\n-\tO\nexposed\tO\ncynomolgus\tO\nmonkeys\tO\nprimed\tO\nto\tO\nexhibit\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nto\tO\nevaluate\tO\nthe\tO\nlocomotor\tO\nand\tO\ndyskinetic\tB-Disease\neffects\tO\non\tO\nchallenge\tO\nwith\tO\nfour\tO\ndoses\tO\n(\tO\nfrom\tO\n0\tO\n.\tO\n03\tO\nto\tO\n1\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nof\tO\nA\tB-Chemical\n-\tI-Chemical\n86929\tI-Chemical\n(\tO\n[\tB-Chemical\n-\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n5aR\tI-Chemical\n,\tI-Chemical\n11bS\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n,\tI-Chemical\n5a\tI-Chemical\n,\tI-Chemical\n6\tI-Chemical\n,\tI-Chemical\n7\tI-Chemical\n,\tI-Chemical\n11b\tI-Chemical\n-\tI-Chemical\nhexahydro\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\npropyl\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nthia\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\n+\tI-Chemical\n+\tI-Chemical\n+\tI-Chemical\nazacyclopent\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nena\tI-Chemical\n[\tI-Chemical\nc\tI-Chemical\n]\tI-Chemical\nphenathrene\tI-Chemical\n-\tI-Chemical\n9\tI-Chemical\n-\tI-Chemical\n10\tI-Chemical\n-\tI-Chemical\ndiol\tI-Chemical\n)\tO\n,\tO\na\tO\nselective\tO\nand\tO\nfull\tO\nDA\tB-Chemical\nD1\tO\n-\tO\nlike\tO\nreceptor\tO\nagonist\tO\nwith\tO\nan\tO\nintermediate\tO\nduration\tO\nof\tO\naction\tO\n.\tO\n\nLevodopa\tB-Chemical\nand\tO\nthe\tO\nDA\tB-Chemical\nD2\tO\n-\tO\nlike\tO\nreceptor\tO\nagonist\tO\n,\tO\nLY\tB-Chemical\n-\tI-Chemical\n171555\tI-Chemical\n(\tO\n[\tB-Chemical\n4aR\tI-Chemical\n-\tI-Chemical\ntrans\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n,\tI-Chemical\n4a\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n,\tI-Chemical\n6\tI-Chemical\n,\tI-Chemical\n7\tI-Chemical\n,\tI-Chemical\n8\tI-Chemical\n,\tI-Chemical\n8a\tI-Chemical\n,\tI-Chemical\n9\tI-Chemical\n-\tI-Chemical\no\tI-Chemical\n-\tI-Chemical\ndihydro\tI-Chemical\n-\tI-Chemical\n5n\tI-Chemical\n-\tI-Chemical\npropyl\tI-Chemical\n-\tI-Chemical\n2H\tI-Chemical\n-\tI-Chemical\npyrazo\tI-Chemical\nlo\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nquinoline\tI-Chemical\nhydrochloride\tI-Chemical\n)\tO\nwere\tO\nalso\tO\nused\tO\nfor\tO\ncomparison\tO\n.\tO\n\nAcute\tO\nadministration\tO\nof\tO\nA\tB-Chemical\n-\tI-Chemical\n86929\tI-Chemical\nwas\tO\nas\tO\nefficacious\tO\nin\tO\nalleviating\tO\nMPTP\tB-Chemical\n-\tO\ninduced\tO\nparkinsonism\tB-Disease\nas\tO\nlevodopa\tB-Chemical\nand\tO\nLY\tB-Chemical\n-\tI-Chemical\n171555\tI-Chemical\n,\tO\nbut\tO\nwas\tO\nless\tO\nlikely\tO\nto\tO\nreproduce\tO\nthe\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nin\tO\nthese\tO\nanimals\tO\nthan\tO\nwith\tO\neither\tO\nLY\tB-Chemical\n-\tI-Chemical\n171555\tI-Chemical\nor\tO\nsubsequent\tO\nchallenge\tO\nof\tO\nlevodopa\tB-Chemical\n.\tO\n\nSelective\tO\nstimulation\tO\nof\tO\nthe\tO\nDA\tB-Chemical\nD1\tO\nreceptor\tO\nmay\tO\nprovide\tO\nbetter\tO\nintegration\tO\nof\tO\nneural\tO\ninputs\tO\ntransmitted\tO\nto\tO\nthe\tO\ninternal\tO\nsegment\tO\nof\tO\nthe\tO\nglobus\tO\npallidus\tO\n(\tO\nreferred\tO\nto\tO\nas\tO\nthe\tO\nbasal\tO\nganglia\tO\noutput\tO\n)\tO\ncompared\tO\nwith\tO\nlevodopa\tB-Chemical\nand\tO\nselective\tO\nDA\tB-Chemical\nD2\tO\nreceptor\tO\nagonist\tO\n.\tO\n\nPotent\tO\nDA\tB-Chemical\nD1\tO\nreceptor\tO\nagents\tO\nwith\tO\nan\tO\nintermediate\tO\nduration\tO\nof\tO\nefficacy\tO\nsuch\tO\nas\tO\nA\tB-Chemical\n-\tI-Chemical\n86929\tI-Chemical\n(\tO\napproximately\tO\n4\tO\nhr\tO\nat\tO\nhigher\tO\ndoses\tO\ntested\tO\n)\tO\nare\tO\npotential\tO\ntherapeutic\tO\ntools\tO\nin\tO\nPD\tB-Disease\nand\tO\nmerit\tO\nfurther\tO\nattention\tO\n.\tO\n\nNeuropeptide\tO\n-\tO\nY\tO\nimmunoreactivity\tO\nin\tO\nthe\tO\npilocarpine\tB-Chemical\nmodel\tO\nof\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\n.\tO\n\nNeuropeptide\tO\n-\tO\nY\tO\n(\tO\nNPY\tO\n)\tO\nis\tO\nexpressed\tO\nby\tO\ngranule\tO\ncells\tO\nand\tO\nmossy\tO\nfibres\tO\nof\tO\nthe\tO\nhippocampal\tO\ndentate\tO\ngyrus\tO\nduring\tO\nexperimental\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\n(\tO\nTLE\tB-Disease\n)\tO\n.\tO\n\nThis\tO\nexpression\tO\nmay\tO\nrepresent\tO\nan\tO\nendogenous\tO\ndamping\tO\nmechanism\tO\nsince\tO\nNPY\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nblock\tO\nseizure\tB-Disease\n-\tO\nlike\tO\nevents\tO\nfollowing\tO\nhigh\tO\n-\tO\nfrequency\tO\nstimulation\tO\nin\tO\nhippocampal\tO\nslices\tO\n.\tO\n\nThe\tO\npilocarpine\tB-Chemical\n(\tO\nPILO\tB-Chemical\n)\tO\nmodel\tO\nof\tO\nepilepsy\tB-Disease\nis\tO\ncharacterized\tO\nby\tO\nan\tO\nacute\tO\nperiod\tO\nof\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nfollowed\tO\nby\tO\nspontaneous\tO\nrecurrent\tO\nseizures\tB-Disease\nand\tO\nrelated\tO\nbrain\tB-Disease\ndamage\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\nperoxidase\tO\n-\tO\nantiperoxidase\tO\nimmunostaining\tO\nfor\tO\nNPY\tO\nin\tO\nseveral\tO\nbrain\tO\nregions\tO\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nPILO\tB-Chemical\n-\tO\ninjected\tO\nanimals\tO\nexhibited\tO\nNPY\tO\nimmunoreactivity\tO\nin\tO\nthe\tO\nregion\tO\nof\tO\nthe\tO\nmossy\tO\nfibre\tO\nterminals\tO\n,\tO\nin\tO\nthe\tO\ndentate\tO\ngyrus\tO\ninner\tO\nmolecular\tO\nlayer\tO\nand\tO\n,\tO\nin\tO\na\tO\nfew\tO\ncases\tO\n,\tO\nwithin\tO\npresumed\tO\ngranule\tO\ncells\tO\n.\tO\n\nNPY\tO\nimmunoreactivity\tO\nwas\tO\nalso\tO\ndramatically\tO\nchanged\tO\nin\tO\nthe\tO\nentorhinal\tO\ncortex\tO\n,\tO\namygdala\tO\nand\tO\nsensorimotor\tO\nareas\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nPILO\tB-Chemical\ninjected\tO\nanimals\tO\nexhibited\tO\na\tO\nreduction\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nNPY\tO\n-\tO\nimmunoreactive\tO\ninterneurons\tO\ncompared\tO\nwith\tO\ncontrols\tO\n.\tO\n\nThe\tO\nresults\tO\ndemonstrate\tO\nthat\tO\nchanges\tO\nin\tO\nNPY\tO\nexpression\tO\n,\tO\nincluding\tO\nexpression\tO\nin\tO\nthe\tO\ngranule\tO\ncells\tO\nand\tO\nmossy\tO\nfibres\tO\nand\tO\nthe\tO\nloss\tO\nof\tO\nvulnerable\tO\nNPY\tO\nneurons\tO\n,\tO\nare\tO\npresent\tO\nin\tO\nthe\tO\nPILO\tB-Chemical\nmodel\tO\nof\tO\nTLE\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nsignificance\tO\nof\tO\nthis\tO\nchanged\tO\nsynthesis\tO\nof\tO\nNPY\tO\nremains\tO\nto\tO\nbe\tO\ndetermined\tO\n.\tO\n\nPosteroventral\tO\nmedial\tO\npallidotomy\tO\nin\tO\nadvanced\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nPosteroventral\tO\nmedial\tO\npallidotomy\tO\nsometimes\tO\nproduces\tO\nstriking\tO\nimprovement\tO\nin\tO\npatients\tO\nwith\tO\nadvanced\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n,\tO\nbut\tO\nthe\tO\nstudies\tO\nto\tO\ndate\tO\nhave\tO\ninvolved\tO\nsmall\tO\nnumbers\tO\nof\tO\npatients\tO\nand\tO\nshort\tO\n-\tO\nterm\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nMETHODS\tO\n:\tO\nForty\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nunderwent\tO\nserial\tO\n,\tO\ndetailed\tO\nassessments\tO\nboth\tO\nafter\tO\ndrug\tO\nwithdrawal\tO\n(\tO\n\"\tO\noff\tO\n\"\tO\nperiod\tO\n)\tO\nand\tO\nwhile\tO\ntaking\tO\ntheir\tO\noptimal\tO\nmedical\tO\nregimens\tO\n(\tO\n\"\tO\non\tO\n\"\tO\nperiod\tO\n)\tO\n.\tO\n\nAll\tO\npatients\tO\nwere\tO\nexamined\tO\npreoperatively\tO\nand\tO\n39\tO\nwere\tO\nexamined\tO\nat\tO\nsix\tO\nmonths\tO\n;\tO\n27\tO\nof\tO\nthe\tO\npatients\tO\nwere\tO\nalso\tO\nexamined\tO\nat\tO\none\tO\nyear\tO\n,\tO\nand\tO\n11\tO\nat\tO\ntwo\tO\nyears\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\npercent\tO\nimprovements\tO\nat\tO\nsix\tO\nmonths\tO\nwere\tO\nas\tO\nfollows\tO\n:\tO\noff\tO\n-\tO\nperiod\tO\nscore\tO\nfor\tO\noverall\tO\nmotor\tO\nfunction\tO\n,\tO\n28\tO\npercent\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n19\tO\nto\tO\n38\tO\npercent\tO\n)\tO\n,\tO\nwith\tO\nmost\tO\nof\tO\nthe\tO\nimprovement\tO\nin\tO\nthe\tO\ncontralateral\tO\nlimbs\tO\n;\tO\noff\tO\n-\tO\nperiod\tO\nscore\tO\nfor\tO\nactivities\tO\nof\tO\ndaily\tO\nliving\tO\n,\tO\n29\tO\npercent\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n19\tO\nto\tO\n39\tO\npercent\tO\n)\tO\n;\tO\non\tO\n-\tO\nperiod\tO\nscore\tO\nfor\tO\ncontralateral\tO\ndyskinesias\tB-Disease\n,\tO\n82\tO\npercent\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n72\tO\nto\tO\n91\tO\npercent\tO\n)\tO\n;\tO\nand\tO\non\tO\n-\tO\nperiod\tO\nscore\tO\nfor\tO\nipsilateral\tO\ndyskinesias\tB-Disease\n,\tO\n44\tO\npercent\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n29\tO\nto\tO\n59\tO\npercent\tO\n)\tO\n.\tO\n\nThe\tO\nimprovements\tO\nin\tO\ndyskinesias\tB-Disease\nand\tO\nthe\tO\ntotal\tO\nscores\tO\nfor\tO\noff\tO\n-\tO\nperiod\tO\nparkinsonism\tB-Disease\n,\tO\ncontralateral\tO\nbradykinesia\tB-Disease\n,\tO\nand\tO\nrigidity\tB-Disease\nwere\tO\nsustained\tO\nin\tO\nthe\tO\n11\tO\npatients\tO\nexamined\tO\nat\tO\ntwo\tO\nyears\tO\n.\tO\n\nThe\tO\nimprovement\tO\nin\tO\nipsilateral\tO\ndyskinesias\tB-Disease\nwas\tO\nlost\tO\nafter\tO\none\tO\nyear\tO\n,\tO\nand\tO\nthe\tO\nimprovements\tO\nin\tO\npostural\tO\nstability\tO\nand\tO\ngait\tO\nlasted\tO\nonly\tO\nthree\tO\nto\tO\nsix\tO\nmonths\tO\n.\tO\n\nApproximately\tO\nhalf\tO\nthe\tO\npatients\tO\nwho\tO\nhad\tO\nbeen\tO\ndependent\tO\non\tO\nassistance\tO\nin\tO\nactivities\tO\nof\tO\ndaily\tO\nliving\tO\nin\tO\nthe\tO\noff\tO\nperiod\tO\nbefore\tO\nsurgery\tO\nbecame\tO\nindependent\tO\nafter\tO\nsurgery\tO\n.\tO\n\nThe\tO\ncomplications\tO\nof\tO\nsurgery\tO\nwere\tO\ngenerally\tO\nwell\tO\ntolerated\tO\n,\tO\nand\tO\nthere\tO\nwere\tO\nno\tO\nsignificant\tO\nchanges\tO\nin\tO\nthe\tO\nuse\tO\nof\tO\nmedication\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\nlate\tO\n-\tO\nstage\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n,\tO\npallidotomy\tO\nsignificantly\tO\nreduces\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nand\tO\noff\tO\n-\tO\nperiod\tO\ndisability\tO\n.\tO\n\nMuch\tO\nof\tO\nthe\tO\nbenefit\tO\nis\tO\nsustained\tO\nat\tO\ntwo\tO\nyears\tO\n,\tO\nalthough\tO\nsome\tO\nimprovements\tO\n,\tO\nsuch\tO\nas\tO\nthose\tO\non\tO\nthe\tO\nipsilateral\tO\nside\tO\nand\tO\nin\tO\naxial\tO\nsymptoms\tO\n,\tO\nwane\tO\nwithin\tO\nthe\tO\nfirst\tO\nyear\tO\n.\tO\n\nThe\tO\non\tO\n-\tO\nperiod\tO\nsymptoms\tO\nthat\tO\nare\tO\nresistant\tO\nto\tO\ndopaminergic\tO\ntherapy\tO\ndo\tO\nnot\tO\nrespond\tO\nto\tO\npallidotomy\tO\n.\tO\n\nClarithromycin\tB-Chemical\n-\tO\ninduced\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n.\tO\n\nClarithromycin\tB-Chemical\nis\tO\na\tO\nrelatively\tO\nnew\tO\nmacrolide\tB-Chemical\nantibiotic\tO\nthat\tO\noffers\tO\ntwice\tO\n-\tO\ndaily\tO\ndosing\tO\n.\tO\n\nIt\tO\ndiffers\tO\nfrom\tO\nerythromycin\tB-Chemical\nonly\tO\nin\tO\nthe\tO\nmethylation\tO\nof\tO\nthe\tO\nhydroxyl\tO\ngroup\tO\nat\tO\nposition\tO\n6\tO\n.\tO\n\nAlthough\tO\nthe\tO\nside\tO\n-\tO\neffect\tO\nprofile\tO\nof\tO\nerythromycin\tB-Chemical\nis\tO\nestablished\tO\n,\tO\nincluding\tO\ngastroenteritis\tB-Disease\nand\tO\ninteractions\tO\nwith\tO\nother\tO\ndrugs\tO\nsubject\tO\nto\tO\nhepatic\tO\nmixed\tO\n-\tO\nfunction\tO\noxidase\tO\nmetabolism\tO\n,\tO\nexperience\tO\nwith\tO\nthe\tO\nnewer\tO\nmacrolides\tB-Chemical\nis\tO\nstill\tO\nbeing\tO\nrecorded\tO\n.\tO\n\nCardiotoxicity\tB-Disease\nhas\tO\nbeen\tO\ndemonstrated\tO\nafter\tO\nboth\tO\nintravenous\tO\nand\tO\noral\tO\nadministration\tO\nof\tO\nerythromycin\tB-Chemical\nbut\tO\nhas\tO\nnever\tO\nbeen\tO\nreported\tO\nwith\tO\nthe\tO\nnewer\tO\nmacrolides\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nventricular\tB-Disease\ndysrhythmias\tI-Disease\nthat\tO\noccurred\tO\nafter\tO\nsix\tO\ntherapeutic\tO\ndoses\tO\nof\tO\nclarithromycin\tB-Chemical\n.\tO\n\nThe\tO\ndysrhythmias\tB-Disease\nresolved\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nEffect\tO\nof\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\non\tO\nthe\tO\nsphincter\tB-Disease\nof\tI-Disease\nOddi\tI-Disease\nspasm\tI-Disease\nevoked\tO\nby\tO\nprostigmine\tB-Chemical\n-\tO\nmorphine\tB-Chemical\nadministration\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nIn\tO\nthis\tO\nstudy\tO\nthe\tO\neffect\tO\nof\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\non\tO\nthe\tO\nprostigmine\tB-Chemical\n-\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nsphincter\tB-Disease\nof\tI-Disease\nOddi\tI-Disease\nspasm\tI-Disease\nwas\tO\nevaluated\tO\nin\tO\nnine\tO\nfemale\tO\npatients\tO\nwith\tO\nsphincter\tB-Disease\nof\tI-Disease\nOddi\tI-Disease\ndyskinesia\tI-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nSphincter\tB-Disease\nof\tI-Disease\nOddi\tI-Disease\nspasm\tI-Disease\nwas\tO\ninduced\tO\nby\tO\nprostigmine\tB-Chemical\n-\tO\nmorphine\tB-Chemical\nadministration\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\nprostigmine\tB-Chemical\nintramuscularly\tO\nand\tO\n10\tO\nmg\tO\nmorphine\tB-Chemical\nsubcutaneously\tO\n)\tO\nand\tO\nvisualized\tO\nby\tO\nquantitative\tO\nhepatobiliary\tO\nscintigraphy\tO\n.\tO\n\nThe\tO\nentire\tO\nprocedure\tO\nwas\tO\nrepeated\tO\nduring\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\ninfusion\tO\n(\tO\nNitrolingual\tB-Chemical\n1\tO\nmicrog\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\nfor\tO\n120\tO\nmin\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nProstigmine\tB-Chemical\n-\tO\nmorphine\tB-Chemical\nprovocation\tO\ncaused\tO\nsignificant\tO\nincreases\tO\nin\tO\nthe\tO\ntime\tO\nto\tO\npeak\tO\nactivity\tO\n(\tO\nTmax\tO\n)\tO\nover\tO\nthe\tO\nhepatic\tO\nhilum\tO\n(\tO\nHH\tO\n:\tO\n34\tO\n.\tO\n33\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n05\tO\nvs\tO\n.\tO\n22\tO\n.\tO\n77\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n26\tO\n)\tO\nand\tO\nthe\tO\ncommon\tO\nbile\tO\nduct\tO\n(\tO\nCBD\tO\n:\tO\n60\tO\n.\tO\n44\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n99\tO\nvs\tO\n.\tO\n40\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n88\tO\n)\tO\nand\tO\nin\tO\nthe\tO\nhalf\tO\n-\tO\ntime\tO\nof\tO\nexcretion\tO\n(\tO\nT1\tO\n/\tO\n2\tO\n)\tO\nover\tO\nthe\tO\nliver\tO\nparenchyma\tO\n(\tO\nLP\tO\n:\tO\n120\tO\n.\tO\n04\tO\n+\tO\n/\tO\n-\tO\n16\tO\n.\tO\n01\tO\nvs\tO\n.\tO\n27\tO\n.\tO\n37\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n19\tO\n)\tO\n,\tO\nHH\tO\n(\tO\n117\tO\n.\tO\n61\tO\n+\tO\n/\tO\n-\tO\n14\tO\n.\tO\n71\tO\nvs\tO\n.\tO\n31\tO\n.\tO\n85\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n99\tO\n)\tO\nand\tO\nCBD\tO\n(\tO\n158\tO\n.\tO\n11\tO\n+\tO\n/\tO\n-\tO\n9\tO\n.\tO\n18\tO\nvs\tO\n.\tO\n40\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n24\tO\n)\tO\n,\tO\nindicating\tO\na\tO\ncomplete\tO\nspasm\tB-Disease\nat\tO\nthe\tO\nlevel\tO\nof\tO\nthe\tO\nsphincter\tO\nof\tO\nOddi\tO\n.\tO\n\nGlyceryl\tB-Chemical\ntrinitrate\tI-Chemical\ninfusion\tO\ncompletely\tO\nnormalized\tO\nthe\tO\nprostigmine\tB-Chemical\n-\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nalterations\tO\nin\tO\nthese\tO\nquantitative\tO\nparameters\tO\n(\tO\nTmaX\tO\nover\tO\nthe\tO\nLP\tO\n:\tO\n11\tO\n.\tO\n33\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n13\tO\n;\tO\nover\tO\nthe\tO\nHH\tO\n:\tO\n18\tO\n.\tO\n88\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n48\tO\n;\tO\nand\tO\nover\tO\nthe\tO\nCBD\tO\n:\tO\n36\tO\n.\tO\n22\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n92\tO\n;\tO\nand\tO\nT1\tO\n/\tO\n2\tO\nover\tO\nthe\tO\nLP\tO\n:\tO\n28\tO\n.\tO\n21\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n83\tO\n;\tO\nover\tO\nthe\tO\nHH\tO\n:\tO\n33\tO\n.\tO\n42\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n10\tO\n;\tO\nand\tO\nover\tO\nthe\tO\nCBD\tO\n:\tO\n41\tO\n.\tO\n66\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n33\tO\n)\tO\n,\tO\nsuggesting\tO\nan\tO\neffective\tO\nsphincter\tO\n-\tO\nrelaxing\tO\neffect\tO\nof\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nThese\tO\nresults\tO\nprovide\tO\nthe\tO\nfirst\tO\nevidence\tO\nof\tO\nthe\tO\neffectiveness\tO\nof\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\non\tO\nthe\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nsphincter\tB-Disease\nof\tI-Disease\nOddi\tI-Disease\nspasm\tI-Disease\nin\tO\nhumans\tO\n.\tO\n\nSince\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\nis\tO\nable\tO\nto\tO\novercome\tO\neven\tO\nthe\tO\ndrastic\tO\neffect\tO\nof\tO\nmorphine\tB-Chemical\n,\tO\nit\tO\nmight\tO\nbe\tO\nof\tO\nrelevance\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nsphincter\tB-Disease\nof\tI-Disease\nOddi\tI-Disease\ndyskinesia\tI-Disease\n.\tO\n\nImmunopathology\tO\nof\tO\npenicillamine\tB-Chemical\n-\tO\ninduced\tO\nglomerular\tB-Disease\ndisease\tI-Disease\n.\tO\n\nFour\tO\npatients\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\ndeveloped\tO\nheavy\tO\nproteinuria\tB-Disease\nafter\tO\nfive\tO\nto\tO\n12\tO\nmonths\tO\nof\tO\ntreatment\tO\nwith\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n.\tO\n\nLight\tO\nmicroscopy\tO\nof\tO\nrenal\tO\nbiopsy\tO\nsamples\tO\nshowed\tO\nminimal\tO\nglomerular\tO\ncapillary\tO\nwall\tO\nthickening\tO\nand\tO\nmesangial\tO\nmatrix\tO\nincrease\tO\n,\tO\nor\tO\nno\tO\ndeparture\tO\nfrom\tO\nnormal\tO\n.\tO\n\nElectron\tO\nmicroscopy\tO\n,\tO\nhowever\tO\n,\tO\nrevealed\tO\nsubepithelial\tO\nelectron\tO\n-\tO\ndense\tO\ndeposits\tO\n,\tO\nfusion\tO\nof\tO\nepithelial\tO\ncell\tO\nfoot\tO\nprocesses\tO\n,\tO\nand\tO\nevidence\tO\nof\tO\nmesangial\tO\ncell\tO\nhyperactivity\tO\n.\tO\n\nImmunofluorescence\tO\nmicroscopy\tO\ndemonstrated\tO\ngranular\tO\ncapillary\tO\nwall\tO\ndeposits\tO\nof\tO\nIgG\tO\nand\tO\nC3\tO\n.\tO\n\nThe\tO\nfindings\tO\nwere\tO\nsimilar\tO\nto\tO\nthose\tO\nin\tO\nearly\tO\nmembranous\tB-Disease\nglomerulonephritis\tI-Disease\n,\tO\ndifferences\tO\nbeing\tO\nobserved\tO\nhowever\tO\nin\tO\nthe\tO\nresults\tO\nof\tO\nstaining\tO\nfor\tO\nthe\tO\nearly\tO\n-\tO\nacting\tO\ncomplement\tO\ncomponents\tO\nC1q\tO\nand\tO\nC4\tO\n.\tO\n\nIt\tO\nis\tO\ntentatively\tO\nconcluded\tO\nthat\tO\ncomplement\tO\nwas\tO\nactivated\tO\nby\tO\nthe\tO\nclassical\tO\npathway\tO\n.\tO\n\nExperimental\tO\ncranial\tO\npain\tB-Disease\nelicited\tO\nby\tO\ncapsaicin\tB-Chemical\n:\tO\na\tO\nPET\tO\nstudy\tO\n.\tO\n\nUsing\tO\na\tO\npositron\tO\nemission\tO\ntomography\tO\n(\tO\nPET\tO\n)\tO\nstudy\tO\nit\tO\nwas\tO\nshown\tO\nrecently\tO\nthat\tO\nin\tO\nmigraine\tB-Disease\nwithout\tO\naura\tO\ncertain\tO\nareas\tO\nin\tO\nthe\tO\nbrain\tO\nstem\tO\nwere\tO\nactivated\tO\nduring\tO\nthe\tO\nheadache\tB-Disease\nstate\tO\n,\tO\nbut\tO\nnot\tO\nin\tO\nthe\tO\nheadache\tB-Disease\nfree\tO\ninterval\tO\n.\tO\n\nIt\tO\nwas\tO\nsuggested\tO\nthat\tO\nthis\tO\nbrain\tO\nstem\tO\nactivation\tO\nis\tO\ninherent\tO\nto\tO\nthe\tO\nmigraine\tB-Disease\nattack\tO\nitself\tO\nand\tO\nrepresents\tO\nthe\tO\nso\tO\ncalled\tO\n'\tO\nmigraine\tB-Disease\ngenerator\tO\n'\tO\n.\tO\n\nTo\tO\ntest\tO\nthis\tO\nhypothesis\tO\nwe\tO\nperformed\tO\nan\tO\nexperimental\tO\npain\tB-Disease\nstudy\tO\nin\tO\nseven\tO\nhealthy\tO\nvolunteers\tO\n,\tO\nusing\tO\nthe\tO\nsame\tO\npositioning\tO\nin\tO\nthe\tO\nPET\tO\nscanner\tO\nas\tO\nin\tO\nthe\tO\nmigraine\tB-Disease\npatients\tO\n.\tO\n\nA\tO\nsmall\tO\namount\tO\nof\tO\ncapsaicin\tB-Chemical\nwas\tO\nadministered\tO\nsubcutaneously\tO\nin\tO\nthe\tO\nright\tO\nforehead\tO\nto\tO\nevoke\tO\na\tO\nburning\tO\npainful\tB-Disease\nsensation\tO\nin\tO\nthe\tO\nfirst\tO\ndivision\tO\nof\tO\nthe\tO\ntrigeminal\tO\nnerve\tO\n.\tO\n\nIncreases\tO\nof\tO\nregional\tO\ncerebral\tO\nblood\tO\nflow\tO\n(\tO\nrCBF\tO\n)\tO\nwere\tO\nfound\tO\nbilaterally\tO\nin\tO\nthe\tO\ninsula\tO\n,\tO\nin\tO\nthe\tO\nanterior\tO\ncingulate\tO\ncortex\tO\n,\tO\nthe\tO\ncavernous\tO\nsinus\tO\nand\tO\nthe\tO\ncerebellum\tO\n.\tO\n\nUsing\tO\nthe\tO\nsame\tO\nstereotactic\tO\nspace\tO\nlimits\tO\nas\tO\nin\tO\nthe\tO\nabove\tO\nmentioned\tO\nmigraine\tB-Disease\nstudy\tO\nno\tO\nbrain\tO\nstem\tO\nactivation\tO\nwas\tO\nfound\tO\nin\tO\nthe\tO\nacute\tO\npain\tB-Disease\nstate\tO\ncompared\tO\nto\tO\nthe\tO\npain\tB-Disease\nfree\tO\nstate\tO\n.\tO\n\nThe\tO\nincrease\tO\nof\tO\nactivation\tO\nin\tO\nthe\tO\nregion\tO\nof\tO\nthe\tO\ncavernous\tO\nsinus\tO\nhowever\tO\n,\tO\nsuggests\tO\nthat\tO\nthis\tO\nstructure\tO\nis\tO\nmore\tO\nlikely\tO\nto\tO\nbe\tO\ninvolved\tO\nin\tO\ntrigeminal\tO\ntransmitted\tO\npain\tB-Disease\nas\tO\nsuch\tO\n,\tO\nrather\tO\nthan\tO\nin\tO\na\tO\nspecific\tO\ntype\tO\nof\tO\nheadache\tB-Disease\nas\tO\nwas\tO\nsuggested\tO\nfor\tO\ncluster\tB-Disease\nheadache\tI-Disease\n.\tO\n\nValue\tO\nof\tO\nmethylprednisolone\tB-Chemical\nin\tO\nprevention\tO\nof\tO\nthe\tO\narthralgia\tB-Disease\n-\tO\nmyalgia\tB-Disease\nsyndrome\tO\nassociated\tO\nwith\tO\nthe\tO\ntotal\tO\ndose\tO\ninfusion\tO\nof\tO\niron\tB-Chemical\ndextran\tI-Chemical\n:\tO\na\tO\ndouble\tO\nblind\tO\nrandomized\tO\ntrial\tO\n.\tO\n\nThe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\ntotal\tO\ndose\tO\ninfusion\tO\n(\tO\nTDI\tO\n)\tO\nof\tO\niron\tB-Chemical\ndextran\tI-Chemical\nhas\tO\nbeen\tO\nwell\tO\ndocumented\tO\n.\tO\n\nIn\tO\n40\tO\n%\tO\nof\tO\ntreated\tO\npatients\tO\n,\tO\nan\tO\narthralgia\tB-Disease\n-\tO\nmyalgia\tB-Disease\nsyndrome\tO\ndevelops\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nprospective\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nwhether\tO\nintravenous\tO\n(\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nadministration\tO\nof\tO\nmethylprednisolone\tB-Chemical\n(\tO\nMP\tB-Chemical\n)\tO\nprevents\tO\nthis\tO\ncomplication\tO\n.\tO\n\nSixty\tO\n-\tO\nfive\tO\npatients\tO\n,\tO\n34\tO\nwomen\tO\nand\tO\n31\tO\nmen\tO\n,\tO\nages\tO\n36\tO\nto\tO\n80\tO\nyears\tO\n,\tO\nreceived\tO\neither\tO\nnormal\tO\nsaline\tO\nbefore\tO\nand\tO\nafter\tO\nTDI\tO\n(\tO\ngroup\tO\n1\tO\n)\tO\n,\tO\n125\tO\nmg\tO\ni\tO\n.\tO\nv\tO\n.\tO\nMP\tB-Chemical\nbefore\tO\nand\tO\nsaline\tO\nafter\tO\nTDI\tO\n(\tO\ngroup\tO\n2\tO\n)\tO\n,\tO\nor\tO\n125\tO\nmg\tO\ni\tO\n.\tO\nv\tO\n.\tO\nMP\tB-Chemical\nbefore\tO\nand\tO\nafter\tO\nTDI\tO\n(\tO\ngroup\tO\n3\tO\n)\tO\n.\tO\n\nPatients\tO\nwere\tO\nobserved\tO\nfor\tO\n72\tO\nhours\tO\nand\tO\nreactions\tO\nwere\tO\nrecorded\tO\nand\tO\ngraded\tO\naccording\tO\nto\tO\nseverity\tO\n.\tO\n\nFifty\tO\n-\tO\neight\tO\npercent\tO\nof\tO\ngroup\tO\n1\tO\npatients\tO\n,\tO\n33\tO\n%\tO\nof\tO\ngroup\tO\n2\tO\n,\tO\nand\tO\n26\tO\n%\tO\nof\tO\ngroup\tO\n3\tO\nhad\tO\nreactions\tO\nto\tO\nTDI\tO\n.\tO\n\nThe\tO\nseverity\tO\nof\tO\nreactions\tO\n(\tO\nminimal\tO\n,\tO\nmild\tO\n,\tO\nand\tO\nmoderate\tO\n,\tO\nrespectively\tO\n)\tO\nwas\tO\nas\tO\nfollows\tO\n:\tO\ngroup\tO\n1\tO\n-\tO\n-\tO\n6\tO\n,\tO\n6\tO\n,\tO\nand\tO\n2\tO\n;\tO\ngroup\tO\n2\tO\n-\tO\n-\tO\n1\tO\n,\tO\n5\tO\n,\tO\nand\tO\n0\tO\n;\tO\ngroup\tO\n3\tO\n-\tO\n-\tO\n5\tO\n,\tO\n1\tO\n,\tO\nand\tO\n0\tO\n.\tO\n\nData\tO\nwere\tO\nanalyzed\tO\nby\tO\nthe\tO\ntwo\tO\n-\tO\nsided\tO\nFisher\tO\n'\tO\ns\tO\nexact\tO\ntest\tO\nusing\tO\n95\tO\n%\tO\nconfidence\tO\nintervals\tO\nwith\tO\nthe\tO\napproximation\tO\nof\tO\nWoolf\tO\n.\tO\n\nThese\tO\ndata\tO\ndemonstrate\tO\nthat\tO\nadministration\tO\nof\tO\nMP\tB-Chemical\nbefore\tO\nand\tO\nafter\tO\nTDI\tO\nreduces\tO\nthe\tO\nfrequency\tO\nand\tO\nseverity\tO\nof\tO\nthe\tO\narthralgia\tB-Disease\n-\tO\nmyalgia\tB-Disease\nsyndrome\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\n125\tO\nmg\tO\ni\tO\n.\tO\nv\tO\n.\tO\nMP\tB-Chemical\nshould\tO\nbe\tO\ngiven\tO\nroutinely\tO\nbefore\tO\nand\tO\nafter\tO\nTDI\tO\nof\tO\niron\tB-Chemical\ndextran\tI-Chemical\n.\tO\n\nProlongation\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nQT\tI-Disease\ninterval\tI-Disease\nrelated\tO\nto\tO\ncisapride\tB-Chemical\n-\tO\ndiltiazem\tB-Chemical\ninteraction\tO\n.\tO\n\nCisapride\tB-Chemical\n,\tO\na\tO\ncytochrome\tO\nP450\tO\n3A4\tO\n(\tO\nCYP3A4\tO\n)\tO\nsubstrate\tO\n,\tO\nis\tO\nwidely\tO\nprescribed\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\ngastrointestinal\tB-Disease\nmotility\tI-Disease\ndisorders\tI-Disease\n.\tO\n\nProlongation\tB-Disease\nof\tI-Disease\nQT\tI-Disease\ninterval\tI-Disease\n,\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n,\tO\nand\tO\nsudden\tB-Disease\ncardiac\tI-Disease\ndeath\tI-Disease\nhave\tO\nbeen\tO\nreported\tO\nafter\tO\nconcomitant\tO\nadministration\tO\nwith\tO\nerythromycin\tB-Chemical\nor\tO\nazole\tB-Chemical\nantifungal\tO\nagents\tO\n,\tO\nbut\tO\nnot\tO\nwith\tO\nother\tO\nCYP3A4\tO\ninhibitors\tO\n.\tO\n\nA\tO\npossible\tO\ndrug\tO\ninteraction\tO\noccurred\tO\nin\tO\na\tO\n45\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwho\tO\nwas\tO\ntaking\tO\ncisapride\tB-Chemical\nfor\tO\ngastroesophageal\tB-Disease\nreflux\tI-Disease\ndisorder\tI-Disease\nand\tO\ndiltiazem\tB-Chemical\n,\tO\nan\tO\nagent\tO\nthat\tO\nhas\tO\ninhibitory\tO\neffect\tO\non\tO\nCYP3A4\tO\n,\tO\nfor\tO\nhypertension\tB-Disease\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nin\tO\nnear\tO\nsyncope\tB-Disease\nand\tO\nhad\tO\nQT\tB-Disease\n-\tI-Disease\ninterval\tI-Disease\nprolongation\tI-Disease\n.\tO\n\nAfter\tO\ndiscontinuing\tO\ncisapride\tB-Chemical\n,\tO\nthe\tO\nQT\tO\ninterval\tO\nreturned\tO\nto\tO\nnormal\tO\nand\tO\nsymptoms\tO\ndid\tO\nnot\tO\nrecur\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\ncaution\tO\nbe\tO\ntaken\tO\nwhen\tO\ncisapride\tB-Chemical\nis\tO\nprescribed\tO\nwith\tO\nany\tO\npotent\tO\ninhibitor\tO\nof\tO\nCYP3A4\tO\n,\tO\nincluding\tO\ndiltiazem\tB-Chemical\n.\tO\n\nCortical\tO\nmotor\tO\noveractivation\tO\nin\tO\nparkinsonian\tB-Disease\npatients\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n-\tO\ninduced\tO\npeak\tO\n-\tO\ndose\tO\ndyskinesia\tB-Disease\n.\tO\n\nWe\tO\nhave\tO\nstudied\tO\nthe\tO\nregional\tO\ncerebral\tO\nblood\tO\nflow\tO\n(\tO\nrCBF\tO\n)\tO\nchanges\tO\ninduced\tO\nby\tO\nthe\tO\nexecution\tO\nof\tO\na\tO\nfinger\tO\n-\tO\nto\tO\n-\tO\nthumb\tO\nopposition\tO\nmotor\tO\ntask\tO\nin\tO\nthe\tO\nsupplementary\tO\nand\tO\nprimary\tO\nmotor\tO\ncortex\tO\nof\tO\ntwo\tO\ngroups\tO\nof\tO\nparkinsonian\tB-Disease\npatients\tO\non\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nmedication\tO\n,\tO\nthe\tO\nfirst\tO\none\tO\nwithout\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\ninduced\tO\ndyskinesia\tB-Disease\n(\tO\nn\tO\n=\tO\n23\tO\n)\tO\nand\tO\nthe\tO\nother\tO\nwith\tO\nmoderate\tO\npeak\tO\n-\tO\ndose\tO\ndyskinesia\tB-Disease\n(\tO\nn\tO\n=\tO\n15\tO\n)\tO\n,\tO\nand\tO\nof\tO\na\tO\ngroup\tO\nof\tO\n14\tO\nnormal\tO\nsubjects\tO\n.\tO\n\nSingle\tO\nphoton\tO\nemission\tO\ntomography\tO\nwith\tO\ni\tO\n.\tO\nv\tO\n.\tO\n133Xe\tO\nwas\tO\nused\tO\nto\tO\nmeasure\tO\nthe\tO\nrCBF\tO\nchanges\tO\n.\tO\n\nThe\tO\ndyskinetic\tB-Disease\nparkinsonian\tB-Disease\npatients\tO\nexhibited\tO\na\tO\npattern\tO\nof\tO\nresponse\tO\nwhich\tO\nwas\tO\nmarkedly\tO\ndifferent\tO\nfrom\tO\nthose\tO\nof\tO\nthe\tO\nnormal\tO\nsubjects\tO\nand\tO\nnon\tO\n-\tO\ndyskinetic\tB-Disease\nparkinsonian\tB-Disease\npatients\tO\n,\tO\nwith\tO\na\tO\nsignificant\tO\noveractivation\tO\nin\tO\nthe\tO\nsupplementary\tO\nmotor\tO\narea\tO\nand\tO\nthe\tO\nipsi\tO\n-\tO\nand\tO\ncontralateral\tO\nprimary\tO\nmotor\tO\nareas\tO\n.\tO\n\nThese\tO\nresults\tO\nare\tO\ncompatible\tO\nwith\tO\nthe\tO\nhypothesis\tO\nthat\tO\nan\tO\nhyperkinetic\tB-Disease\nabnormal\tB-Disease\ninvoluntary\tI-Disease\nmovement\tI-Disease\n,\tO\nlike\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n-\tO\ninduced\tO\npeak\tO\ndose\tO\ndyskinesia\tB-Disease\n,\tO\nis\tO\ndue\tO\nto\tO\na\tO\ndisinhibition\tO\nof\tO\nthe\tO\nprimary\tO\nand\tO\nassociated\tO\nmotor\tO\ncortex\tO\nsecondary\tO\nto\tO\nan\tO\nexcessive\tO\noutflow\tO\nof\tO\nthe\tO\npallidothalamocortical\tO\nmotor\tO\nloop\tO\n.\tO\n\nOpen\tO\n-\tO\nlabel\tO\nassessment\tO\nof\tO\nlevofloxacin\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nacute\tO\nbacterial\tO\nsinusitis\tB-Disease\nin\tO\nadults\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\nlevofloxacin\tB-Chemical\n(\tO\n500\tO\nmg\tO\norally\tO\nonce\tO\ndaily\tO\nfor\tO\n10\tO\nto\tO\n14\tO\ndays\tO\n)\tO\nin\tO\ntreating\tO\nadult\tO\noutpatients\tO\nwith\tO\nacute\tO\nbacterial\tO\nsinusitis\tB-Disease\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n329\tO\npatients\tO\nenrolled\tO\nin\tO\nthe\tO\nstudy\tO\nat\tO\n24\tO\ncenters\tO\n.\tO\n\nAll\tO\npatients\tO\nhad\tO\na\tO\npre\tO\n-\tO\ntherapy\tO\nGram\tO\n'\tO\ns\tO\nstain\tO\nand\tO\nculture\tO\nof\tO\nsinus\tO\nexudate\tO\nobtained\tO\nby\tO\nantral\tO\npuncture\tO\nor\tO\nnasal\tO\nendoscopy\tO\n.\tO\n\nClinical\tO\nresponse\tO\nwas\tO\nassessed\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\nsigns\tO\nand\tO\nsymptoms\tO\nand\tO\nsinus\tO\nradiograph\tO\nor\tO\ncomputed\tO\ntomography\tO\nresults\tO\n.\tO\n\nMicrobiologic\tO\ncure\tO\nrates\tO\nwere\tO\ndetermined\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\npresumed\tO\nplus\tO\ndocumented\tO\neradication\tO\nof\tO\nthe\tO\npre\tO\n-\tO\ntherapy\tO\npathogen\tO\n(\tO\ns\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nmost\tO\ncommon\tO\npathogens\tO\nwere\tO\nHaemophilus\tO\ninfluenzae\tO\n,\tO\nStreptococcus\tO\npneumoniae\tO\n,\tO\nStaphylococcus\tO\naureus\tO\n,\tO\nand\tO\nMoraxella\tO\ncatarrhalis\tO\n.\tO\n\nOf\tO\n300\tO\nclinically\tO\nevaluable\tO\npatients\tO\n,\tO\n175\tO\n(\tO\n58\tO\n%\tO\n)\tO\nwere\tO\ncured\tO\nand\tO\n90\tO\n(\tO\n30\tO\n%\tO\n)\tO\nwere\tO\nimproved\tO\nat\tO\nthe\tO\npost\tO\n-\tO\ntherapy\tO\nevaluation\tO\n,\tO\nresulting\tO\nin\tO\na\tO\nclinical\tO\nsuccess\tO\nrate\tO\nof\tO\n88\tO\n%\tO\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\npatients\tO\n(\tO\n12\tO\n%\tO\n)\tO\nclinically\tO\nfailed\tO\ntreatment\tO\n.\tO\n\nThe\tO\nmicrobiologic\tO\neradication\tO\nrate\tO\n(\tO\npresumed\tO\nplus\tO\ndocumented\tO\n)\tO\namong\tO\n138\tO\nmicrobiologically\tO\nevaluable\tO\npatients\tO\nwas\tO\n92\tO\n%\tO\n.\tO\n\nMicrobiologic\tO\neradication\tO\nrates\tO\n(\tO\npresumed\tO\nplus\tO\ndocumented\tO\n)\tO\nof\tO\nthe\tO\nmost\tO\ncommon\tO\npathogens\tO\nranged\tO\nfrom\tO\n93\tO\n%\tO\n(\tO\nM\tO\n.\tO\ncatarrhalis\tO\n)\tO\nto\tO\n100\tO\n%\tO\n(\tO\nS\tO\n.\tO\npneumoniae\tO\n)\tO\nat\tO\nthe\tO\npost\tO\n-\tO\ntherapy\tO\nvisit\tO\n.\tO\n\nAll\tO\nbut\tO\none\tO\nof\tO\nthe\tO\n265\tO\npatients\tO\nwho\tO\nwere\tO\ncured\tO\nor\tO\nimproved\tO\nat\tO\npost\tO\n-\tO\ntherapy\tO\nreturned\tO\nfor\tO\na\tO\nlong\tO\n-\tO\nterm\tO\nfollow\tO\n-\tO\nup\tO\nvisit\tO\n;\tO\n243\tO\n(\tO\n92\tO\n%\tO\n)\tO\nremained\tO\nwell\tO\n4\tO\nto\tO\n6\tO\nweeks\tO\nafter\tO\ntherapy\tO\n;\tO\nand\tO\n21\tO\n(\tO\n8\tO\n%\tO\n)\tO\nhad\tO\na\tO\nrelapse\tO\nof\tO\nsymptoms\tO\n.\tO\n\nAdverse\tO\nevents\tO\nconsidered\tO\nto\tO\nbe\tO\nrelated\tO\nto\tO\nlevofloxacin\tB-Chemical\nadministration\tO\nwere\tO\nreported\tO\nby\tO\n29\tO\npatients\tO\n(\tO\n9\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\ndrug\tO\n-\tO\nrelated\tO\nadverse\tO\nevents\tO\nwere\tO\ndiarrhea\tB-Disease\n,\tO\nflatulence\tB-Disease\n,\tO\nand\tO\nnausea\tB-Disease\n;\tO\nmost\tO\nadverse\tO\nevents\tO\nwere\tO\nmild\tO\nto\tO\nmoderate\tO\nin\tO\nseverity\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nresults\tO\nof\tO\nthis\tO\nstudy\tO\nindicate\tO\nthat\tO\nlevofloxacin\tB-Chemical\n500\tO\nmg\tO\nonce\tO\ndaily\tO\nis\tO\nan\tO\neffective\tO\nand\tO\nsafe\tO\ntreatment\tO\nfor\tO\nacute\tO\nbacterial\tO\nsinusitis\tB-Disease\n.\tO\n\nIatrogenic\tO\nrisks\tO\nof\tO\nendometrial\tB-Disease\ncarcinoma\tI-Disease\nafter\tO\ntreatment\tO\nfor\tO\nbreast\tB-Disease\ncancer\tI-Disease\nin\tO\na\tO\nlarge\tO\nFrench\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nF\tO\nd\tO\nration\tO\nNationale\tO\ndes\tO\nCentres\tO\nde\tO\nLutte\tO\nContre\tO\nle\tO\nCancer\tO\n(\tO\nFNCLCC\tO\n)\tO\n.\tO\n\nSince\tO\ntamoxifen\tB-Chemical\nis\tO\nwidely\tO\nused\tO\nin\tO\nbreast\tB-Disease\ncancer\tI-Disease\ntreatment\tO\nand\tO\nhas\tO\nbeen\tO\nproposed\tO\nfor\tO\nthe\tO\nprevention\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\nits\tO\nendometrial\tO\niatrogenic\tO\neffects\tO\nmust\tO\nbe\tO\ncarefully\tO\nexamined\tO\n.\tO\n\nWe\tO\nhave\tO\ninvestigated\tO\nthe\tO\nassociation\tO\nbetween\tO\nendometrial\tB-Disease\ncancer\tI-Disease\nand\tO\ntamoxifen\tB-Chemical\nuse\tO\nor\tO\nother\tO\ntreatments\tO\nin\tO\nwomen\tO\ntreated\tO\nfor\tO\nbreast\tB-Disease\ncancer\tI-Disease\nin\tO\na\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nCases\tO\nof\tO\nendometrial\tB-Disease\ncancer\tI-Disease\ndiagnosed\tO\nafter\tO\nbreast\tB-Disease\ncancer\tI-Disease\n(\tO\nn\tO\n=\tO\n135\tO\n)\tO\nand\tO\n467\tO\ncontrols\tO\nmatched\tO\nfor\tO\nage\tO\n,\tO\nyear\tO\nof\tO\ndiagnosis\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\nand\tO\nhospital\tO\nand\tO\nsurvival\tO\ntime\tO\nwith\tO\nan\tO\nintact\tO\nuterus\tO\nwere\tO\nincluded\tO\n.\tO\n\nWomen\tO\nwho\tO\nhad\tO\nreceived\tO\ntamoxifen\tB-Chemical\nwere\tO\nsignificantly\tO\nmore\tO\nlikely\tO\nto\tO\nhave\tO\nendometrial\tB-Disease\ncancer\tI-Disease\ndiagnosed\tO\nthan\tO\nthose\tO\nwho\tO\nhad\tO\nnot\tO\n(\tO\ncrude\tO\nrelative\tO\nrisk\tO\n=\tO\n4\tO\n.\tO\n9\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nUnivariate\tO\nand\tO\nadjusted\tO\nanalyses\tO\nshowed\tO\nthat\tO\nthe\tO\nrisk\tO\nincreased\tO\nwith\tO\nthe\tO\nlength\tO\nof\tO\ntreatment\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n0001\tO\n)\tO\nor\tO\nthe\tO\ncumulative\tO\ndose\tO\nof\tO\ntamoxifen\tB-Chemical\nreceived\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n,\tO\nirrespective\tO\nof\tO\nthe\tO\ndaily\tO\ndose\tO\n.\tO\n\nWomen\tO\nwho\tO\nhad\tO\nundergone\tO\npelvic\tO\nradiotherapy\tO\nalso\tO\nhad\tO\na\tO\nhigher\tO\nrisk\tO\n(\tO\ncrude\tO\nrelative\tO\nrisk\tO\n=\tO\n7\tO\n.\tO\n8\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nAfter\tO\nadjusting\tO\nfor\tO\nconfounding\tO\nfactors\tO\n,\tO\nthe\tO\nrisk\tO\nwas\tO\nhigher\tO\nfor\tO\ntamoxifen\tB-Chemical\nusers\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n0012\tO\n)\tO\n,\tO\ntreatment\tO\nfor\tO\nmore\tO\nthan\tO\n3\tO\nyears\tO\n(\tO\nall\tO\np\tO\n<\tO\n0\tO\n.\tO\n03\tO\n)\tO\nand\tO\npelvic\tO\nradiotherapy\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n012\tO\n)\tO\n.\tO\n\nWomen\tO\nwho\tO\nhad\tO\nendometrial\tB-Disease\ncancer\tI-Disease\nand\tO\nhad\tO\nreceived\tO\ntamoxifen\tB-Chemical\nhad\tO\nmore\tO\nadvanced\tB-Disease\ndisease\tI-Disease\nand\tO\npoorer\tO\nprognosis\tO\nthan\tO\nthose\tO\nwith\tO\nendometrial\tB-Disease\ncancer\tI-Disease\nwho\tO\nhad\tO\nnot\tO\nreceived\tO\nthis\tO\ntreatment\tO\n.\tO\n\nOur\tO\nresults\tO\nsuggest\tO\na\tO\ncausal\tO\nrole\tO\nof\tO\ntamoxifen\tB-Chemical\nin\tO\nendometrial\tB-Disease\ncancer\tI-Disease\n,\tO\nparticularly\tO\nwhen\tO\nused\tO\nas\tO\ncurrently\tO\nproposed\tO\nfor\tO\nbreast\tB-Disease\ncancer\tI-Disease\nprevention\tO\n.\tO\n\nPelvic\tO\nradiotherapy\tO\nmay\tO\nbe\tO\nan\tO\nadditional\tO\niatrogenic\tO\nfactor\tO\nfor\tO\nwomen\tO\nwith\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nEndometrial\tB-Disease\ncancers\tI-Disease\ndiagnosed\tO\nin\tO\nwomen\tO\ntreated\tO\nwith\tO\ntamoxifen\tB-Chemical\nhave\tO\npoorer\tO\nprognosis\tO\n.\tO\n\nWomen\tO\nwho\tO\nreceive\tO\ntamoxifen\tB-Chemical\nfor\tO\nbreast\tB-Disease\ncancer\tI-Disease\nshould\tO\nbe\tO\noffered\tO\ngynaecological\tO\nsurveillance\tO\nduring\tO\nand\tO\nafter\tO\ntreatment\tO\n.\tO\n\nA\tO\nlong\tO\n-\tO\nterm\tO\nevaluation\tO\nof\tO\nthe\tO\nrisk\tO\n-\tO\nbenefit\tO\nratio\tO\nof\tO\ntamoxifen\tB-Chemical\nas\tO\na\tO\npreventive\tO\ntreatment\tO\nfor\tO\nbreast\tB-Disease\ncancer\tI-Disease\nis\tO\nclearly\tO\nwarranted\tO\n.\tO\n\nContribution\tO\nof\tO\nthe\tO\nglycine\tB-Chemical\nsite\tO\nof\tO\nNMDA\tB-Chemical\nreceptors\tO\nin\tO\nrostral\tO\nand\tO\nintermediate\tO\n-\tO\ncaudal\tO\nparts\tO\nof\tO\nthe\tO\nstriatum\tO\nto\tO\nthe\tO\nregulation\tO\nof\tO\nmuscle\tO\ntone\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\nassess\tO\nthe\tO\ncontribution\tO\nof\tO\nthe\tO\nglycine\tB-Chemical\nsite\tO\nof\tO\nNMDA\tB-Chemical\nreceptors\tO\nin\tO\nthe\tO\nstriatum\tO\nto\tO\nthe\tO\nregulation\tO\nof\tO\nmuscle\tO\ntone\tO\n.\tO\n\nMuscle\tO\ntone\tO\nwas\tO\nexamined\tO\nusing\tO\na\tO\ncombined\tO\nmechanoand\tO\nelectromyographic\tO\nmethod\tO\n,\tO\nwhich\tO\nmeasured\tO\nsimultaneously\tO\nthe\tO\nmuscle\tO\nresistance\tO\n(\tO\nMMG\tO\n)\tO\nof\tO\nthe\tO\nrat\tO\n'\tO\ns\tO\nhind\tO\nfoot\tO\nto\tO\npassive\tO\nextension\tO\nand\tO\nflexion\tO\nin\tO\nthe\tO\nankle\tO\njoint\tO\nand\tO\nthe\tO\nelectromyographic\tO\nactivity\tO\n(\tO\nEMG\tO\n)\tO\nof\tO\nthe\tO\nantagonistic\tO\nmuscles\tO\nof\tO\nthat\tO\njoint\tO\n:\tO\ngastrocnemius\tO\nand\tO\ntibialis\tO\nanterior\tO\n.\tO\n\nMuscle\tB-Disease\nrigidity\tI-Disease\nwas\tO\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\n5\tB-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\ndichlorokynurenic\tI-Chemical\nacid\tI-Chemical\n(\tO\n5\tB-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\nDCKA\tI-Chemical\n)\tO\n,\tO\na\tO\nselective\tO\nglycine\tB-Chemical\nsite\tO\nantagonist\tO\n,\tO\ninjected\tO\nin\tO\ndoses\tO\nof\tO\n2\tO\n.\tO\n5\tO\nand\tO\n4\tO\n.\tO\n5\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\nbilaterally\tO\n,\tO\ninto\tO\nthe\tO\nrostral\tO\nregion\tO\nof\tO\nthe\tO\nstriatum\tO\n,\tO\ndecreased\tO\nboth\tO\nthe\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\nmuscle\tB-Disease\nrigidity\tI-Disease\n(\tO\nMMG\tO\n)\tO\nand\tO\nthe\tO\nenhanced\tO\nelectromyographic\tO\nactivity\tO\n(\tO\nEMG\tO\n)\tO\n.\tO\n\n5\tB-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\nDCKA\tI-Chemical\ninjected\tO\nbilaterally\tO\nin\tO\na\tO\ndose\tO\nof\tO\n4\tO\n.\tO\n5\tO\nmicrog\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmicrol\tO\ninto\tO\nthe\tO\nintermediate\tO\n-\tO\ncaudal\tO\nregion\tO\nof\tO\nthe\tO\nstriatum\tO\nof\tO\nrats\tO\nnot\tO\npretreated\tO\nwith\tO\nhaloperidol\tB-Chemical\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nmuscle\tO\ntone\tO\n.\tO\n\nThe\tO\npresent\tO\nresults\tO\nsuggest\tO\nthat\tO\nblockade\tO\nof\tO\nthe\tO\nglycine\tB-Chemical\nsite\tO\nof\tO\nNMDA\tB-Chemical\nreceptors\tO\nin\tO\nthe\tO\nrostral\tO\npart\tO\nof\tO\nthe\tO\nstriatum\tO\nmay\tO\nbe\tO\nmainly\tO\nresponsible\tO\nfor\tO\nthe\tO\nantiparkinsonian\tO\naction\tO\nof\tO\nthis\tO\ndrug\tO\n.\tO\n\nCarboplatin\tB-Chemical\ntoxic\tO\neffects\tO\non\tO\nthe\tO\nperipheral\tO\nnervous\tO\nsystem\tO\nof\tO\nthe\tO\nrat\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nmost\tO\nstriking\tO\nof\tO\ncarboplatin\tB-Chemical\n'\tO\ns\tO\nadvantages\tO\n(\tO\nCBDCA\tB-Chemical\n)\tO\nover\tO\ncisplatin\tB-Chemical\n(\tO\nCDDP\tB-Chemical\n)\tO\nis\tO\nits\tO\nmarkedly\tO\nreduced\tO\nrate\tO\nof\tO\nneurotoxic\tB-Disease\neffects\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nuse\tO\nof\tO\nCBDCA\tB-Chemical\nhigher\tO\n-\tO\nintensity\tO\nschedules\tO\nand\tO\nthe\tO\nassociation\tO\nwith\tO\nother\tO\nneurotoxic\tB-Disease\ndrugs\tO\nin\tO\npolychemotherapy\tO\nmay\tO\ncause\tO\nsome\tO\nconcern\tO\nabout\tO\nits\tO\nsafety\tO\nwith\tO\nrespect\tO\nto\tO\nperipheral\tB-Disease\nnervous\tI-Disease\nsystem\tI-Disease\ndamage\tI-Disease\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nTwo\tO\ndifferent\tO\nschedules\tO\nof\tO\nCBDCA\tB-Chemical\nadministration\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nand\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\ntwice\tO\na\tO\nweek\tO\nfor\tO\nnine\tO\ntimes\tO\n)\tO\nwere\tO\nevaluated\tO\nin\tO\nWistar\tO\nrats\tO\n.\tO\n\nNeurotoxicity\tB-Disease\nwas\tO\nassessed\tO\nfor\tO\nbehavioral\tO\n(\tO\ntail\tO\n-\tO\nflick\tO\ntest\tO\n)\tO\n,\tO\nneurophysiological\tO\n(\tO\nnerve\tO\nconduction\tO\nvelocity\tO\nin\tO\nthe\tO\ntail\tO\nnerve\tO\n)\tO\n,\tO\nmorphological\tO\n,\tO\nmorphometrical\tO\nand\tO\nanalytical\tO\neffects\tO\n.\tO\n\nRESULTS\tO\n:\tO\nCBDCA\tB-Chemical\nadministration\tO\ninduced\tO\ndose\tO\n-\tO\ndependent\tO\nperipheral\tB-Disease\nneurotoxicity\tI-Disease\n.\tO\n\nPain\tB-Disease\nperception\tO\nand\tO\nnerve\tO\nconduction\tO\nvelocity\tO\nin\tO\nthe\tO\ntail\tO\nwere\tO\nsignificantly\tO\nimpaired\tO\n,\tO\nparticularly\tO\nafter\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ntreatment\tO\n.\tO\n\nThe\tO\ndorsal\tO\nroot\tO\nganglia\tO\nsensory\tO\nneurons\tO\nand\tO\n,\tO\nto\tO\na\tO\nlesser\tO\nextent\tO\n,\tO\nsatellite\tO\ncells\tO\nshowed\tO\nthe\tO\nsame\tO\nchanges\tO\nas\tO\nthose\tO\ninduced\tO\nby\tO\nCDDP\tB-Chemical\n,\tO\nmainly\tO\naffecting\tO\nthe\tO\nnucleus\tO\nand\tO\nnucleolus\tO\nof\tO\nganglionic\tO\nsensory\tO\nneurons\tO\n.\tO\n\nMoreover\tO\n,\tO\nsignificant\tO\namounts\tO\nof\tO\nplatinum\tB-Chemical\nwere\tO\ndetected\tO\nin\tO\nthe\tO\ndorsal\tO\nroot\tO\nganglia\tO\nand\tO\nkidney\tO\nafter\tO\nCBDCA\tB-Chemical\ntreatment\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCBDCA\tB-Chemical\nis\tO\nneurotoxic\tB-Disease\nin\tO\nour\tO\nmodel\tO\n,\tO\nand\tO\nthe\tO\ntype\tO\nof\tO\npathological\tO\nchanges\tO\nit\tO\ninduces\tO\nare\tO\nso\tO\nclosely\tO\nsimilar\tO\nto\tO\nthose\tO\ncaused\tO\nby\tO\nCDDP\tB-Chemical\nthat\tO\nit\tO\nis\tO\nprobable\tO\nthat\tO\nneurotoxicity\tB-Disease\nis\tO\ninduced\tO\nin\tO\nthe\tO\ntwo\tO\ndrugs\tO\nby\tO\nthe\tO\nsame\tO\nmechanism\tO\n.\tO\n\nThis\tO\nmodel\tO\ncan\tO\nbe\tO\nused\tO\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nother\tO\ndrugs\tO\nto\tO\nexplore\tO\nthe\tO\neffect\tO\nof\tO\nCBDCA\tB-Chemical\non\tO\nthe\tO\nperipheral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nEffects\tO\nof\tO\ncisapride\tB-Chemical\non\tO\nsymptoms\tO\nand\tO\npostcibal\tO\nsmall\tO\n-\tO\nbowel\tO\nmotor\tO\nfunction\tO\nin\tO\npatients\tO\nwith\tO\nirritable\tB-Disease\nbowel\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nIrritable\tB-Disease\nbowel\tI-Disease\nsyndrome\tI-Disease\nis\tO\na\tO\ncommon\tO\ncause\tO\nof\tO\nabdominal\tB-Disease\npain\tI-Disease\nand\tO\ndiscomfort\tO\nand\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\ndisordered\tB-Disease\ngastrointestinal\tI-Disease\nmotility\tI-Disease\n.\tO\n\nOur\tO\naim\tO\nwas\tO\nto\tO\nassess\tO\nthe\tO\neffects\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\ntreatment\tO\nwith\tO\na\tO\nprokinetic\tO\nagent\tO\n,\tO\ncisapride\tB-Chemical\n,\tO\non\tO\npostprandial\tO\njejunal\tO\nmotility\tO\nand\tO\nsymptoms\tO\nin\tO\nthe\tO\nirritable\tB-Disease\nbowel\tI-Disease\nsyndrome\tI-Disease\n(\tO\nIBS\tB-Disease\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThirty\tO\n-\tO\neight\tO\npatients\tO\nwith\tO\nIBS\tB-Disease\n(\tO\nconstipation\tB-Disease\n-\tO\npredominant\tO\n,\tO\nn\tO\n=\tO\n17\tO\n;\tO\ndiarrhoea\tB-Disease\n-\tO\npredominant\tO\n,\tO\nn\tO\n=\tO\n21\tO\n)\tO\nunderwent\tO\n24\tO\n-\tO\nh\tO\nambulatory\tO\njejunal\tO\nmanometry\tO\nbefore\tO\nand\tO\nafter\tO\n12\tO\nweek\tO\n'\tO\ns\tO\ntreatment\tO\n[\tO\ncisapride\tB-Chemical\n,\tO\n5\tO\nmg\tO\nthree\tO\ntimes\tO\ndaily\tO\n(\tO\nn\tO\n=\tO\n19\tO\n)\tO\nor\tO\nplacebo\tO\n(\tO\nn\tO\n=\tO\n19\tO\n)\tO\n]\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIn\tO\ndiarrhoea\tB-Disease\n-\tO\npredominant\tO\npatients\tO\nsignificant\tO\ndifferences\tO\nin\tO\ncontraction\tO\ncharacteristics\tO\nwere\tO\nobserved\tO\nbetween\tO\nthe\tO\ncisapride\tB-Chemical\nand\tO\nplacebo\tO\ngroups\tO\n.\tO\n\nIn\tO\ncisapride\tB-Chemical\n-\tO\ntreated\tO\ndiarrhoea\tB-Disease\n-\tO\npredominant\tO\npatients\tO\nthe\tO\nmean\tO\ncontraction\tO\namplitude\tO\nwas\tO\nhigher\tO\n(\tO\n29\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n2\tO\nversus\tO\n24\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n6\tO\nmm\tO\nHg\tO\n,\tO\ncisapride\tB-Chemical\nversus\tO\nplacebo\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n;\tO\npretreatment\tO\n,\tO\n25\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n0\tO\nmm\tO\nHg\tO\n)\tO\n,\tO\nthe\tO\nmean\tO\ncontraction\tO\nduration\tO\nlonger\tO\n(\tO\n3\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nversus\tO\n3\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nsec\tO\n,\tO\ncisapride\tB-Chemical\nversus\tO\nplacebo\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n;\tO\npretreatment\tO\n,\tO\n3\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n5\tO\nsec\tO\n)\tO\n,\tO\nand\tO\nthe\tO\nmean\tO\ncontraction\tO\nfrequency\tO\nlower\tO\n(\tO\n2\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nversus\tO\n2\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n4\tO\ncont\tO\n.\tO\n/\tO\nmin\tO\n,\tO\ncisapride\tB-Chemical\nversus\tO\nplacebo\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n;\tO\npretreatment\tO\n,\tO\n2\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n1\tO\ncont\tO\n.\tO\n/\tO\nmin\tO\n]\tO\nthan\tO\npatients\tO\ntreated\tO\nwith\tO\nplacebo\tO\n.\tO\n\nNo\tO\nsignificant\tO\ndifferences\tO\nin\tO\njejunal\tO\nmotility\tO\nwere\tO\nfound\tO\nin\tO\nthe\tO\nconstipation\tB-Disease\n-\tO\npredominant\tO\nIBS\tB-Disease\ngroup\tO\n.\tO\n\nSymptoms\tO\nwere\tO\nassessed\tO\nby\tO\nusing\tO\na\tO\nvisual\tO\nanalogue\tO\nscale\tO\nbefore\tO\nand\tO\nafter\tO\ntreatment\tO\n.\tO\n\nSymptom\tO\nscores\tO\nrelating\tO\nto\tO\nthe\tO\nseverity\tO\nof\tO\nconstipation\tB-Disease\nwere\tO\nlower\tO\nin\tO\ncisapride\tB-Chemical\n-\tO\ntreated\tO\nconstipation\tB-Disease\n-\tO\npredominant\tO\nIBS\tB-Disease\npatients\tO\n[\tO\nscore\tO\n,\tO\n54\tO\n+\tO\n/\tO\n-\tO\n5\tO\nversus\tO\n67\tO\n+\tO\n/\tO\n-\tO\n14\tO\nmm\tO\n,\tO\ncisapride\tB-Chemical\nversus\tO\nplacebo\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n;\tO\npretreatment\tO\n,\tO\n62\tO\n+\tO\n/\tO\n-\tO\n19\tO\nmm\tO\n]\tO\n.\tO\n\nDiarrhoea\tB-Disease\n-\tO\npredominant\tO\nIBS\tB-Disease\npatients\tO\nhad\tO\na\tO\nhigher\tO\npain\tB-Disease\nscore\tO\nafter\tO\ncisapride\tB-Chemical\ntherapy\tO\n[\tO\nscore\tO\n,\tO\n55\tO\n+\tO\n/\tO\n-\tO\n15\tO\nversus\tO\n34\tO\n+\tO\n/\tO\n-\tO\n12\tO\nmm\tO\n,\tO\ncisapride\tB-Chemical\nversus\tO\nplacebo\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n;\tO\npretreatment\tO\n,\tO\n67\tO\n+\tO\n/\tO\n-\tO\n19\tO\nmm\tO\n]\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nCisapride\tB-Chemical\naffects\tO\njejunal\tO\ncontraction\tO\ncharacteristics\tO\nand\tO\nsome\tO\nsymptoms\tO\nin\tO\nIBS\tB-Disease\n.\tO\n\nPrevention\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\nwith\tO\ntamoxifen\tB-Chemical\n:\tO\npreliminary\tO\nfindings\tO\nfrom\tO\nthe\tO\nItalian\tO\nrandomised\tO\ntrial\tO\namong\tO\nhysterectomised\tO\nwomen\tO\n.\tO\n\nItalian\tO\nTamoxifen\tB-Chemical\nPrevention\tO\nStudy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nTamoxifen\tB-Chemical\nis\tO\na\tO\ncandidate\tO\nchemopreventive\tO\nagent\tO\nin\tO\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\nalthough\tO\nthe\tO\ndrug\tO\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nendometrial\tB-Disease\ncancer\tI-Disease\n.\tO\n\nTherefore\tO\nwe\tO\ndid\tO\na\tO\ntrial\tO\nin\tO\nhysterectomised\tO\nwomen\tO\nof\tO\ntamoxifen\tB-Chemical\nas\tO\na\tO\nchemopreventive\tO\n.\tO\n\nMETHODS\tO\n:\tO\nIn\tO\nOctober\tO\n,\tO\n1992\tO\n,\tO\nwe\tO\nstarted\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\nrandomised\tO\ntrial\tO\nof\tO\ntamoxifen\tB-Chemical\nin\tO\nwomen\tO\n(\tO\nmainly\tO\nin\tO\nItaly\tO\n)\tO\nwho\tO\ndid\tO\nnot\tO\nhave\tO\nbreast\tB-Disease\ncancer\tI-Disease\nand\tO\nwho\tO\nhad\tO\nhad\tO\na\tO\nhysterectomy\tO\n.\tO\n\nWomen\tO\nwere\tO\nrandomised\tO\nto\tO\nreceive\tO\ntamoxifen\tB-Chemical\n20\tO\nmg\tO\nper\tO\nday\tO\nor\tO\nplacebo\tO\n,\tO\nboth\tO\norally\tO\nfor\tO\n5\tO\nyears\tO\n.\tO\n\nThe\tO\noriginal\tO\nplan\tO\nwas\tO\nto\tO\nfollow\tO\nthe\tO\nintervention\tO\nphase\tO\nby\tO\n5\tO\nyears\tO\n'\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nIn\tO\nJune\tO\n,\tO\n1997\tO\n,\tO\nthe\tO\ntrialists\tO\nand\tO\nthe\tO\ndata\tO\n-\tO\nmonitoring\tO\ncommittee\tO\ndecided\tO\nto\tO\nend\tO\nrecruitment\tO\nprimarily\tO\nbecause\tO\nof\tO\nthe\tO\nnumber\tO\nof\tO\nwomen\tO\ndropping\tO\nout\tO\nof\tO\nthe\tO\nstudy\tO\n.\tO\n\nRecruitment\tO\nended\tO\non\tO\nJuly\tO\n11\tO\n,\tO\n1997\tO\n,\tO\nand\tO\nthe\tO\nstudy\tO\nwill\tO\ncontinue\tO\nas\tO\nplanned\tO\n.\tO\n\nThe\tO\nprimary\tO\nendpoints\tO\nare\tO\nthe\tO\noccurrence\tO\nof\tO\nand\tO\ndeaths\tO\nfrom\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nThis\tO\npreliminary\tO\ninterim\tO\nanalysis\tO\nis\tO\nbased\tO\non\tO\nintention\tO\n-\tO\nto\tO\n-\tO\ntreat\tO\n.\tO\n\nFINDINGS\tO\n:\tO\n5408\tO\nwomen\tO\nwere\tO\nrandomised\tO\n;\tO\nparticipating\tO\nwomen\tO\nhave\tO\na\tO\nmedian\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n46\tO\nmonths\tO\nfor\tO\nmajor\tO\nendpoints\tO\n.\tO\n\n41\tO\ncases\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\noccurred\tO\nso\tO\nfar\tO\n;\tO\nthere\tO\nhave\tO\nbeen\tO\nno\tO\ndeaths\tO\nfrom\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nThere\tO\nis\tO\nno\tO\ndifference\tO\nin\tO\nbreast\tB-Disease\n-\tI-Disease\ncancer\tI-Disease\nfrequency\tO\nbetween\tO\nthe\tO\nplacebo\tO\n(\tO\n22\tO\ncases\tO\n)\tO\nand\tO\ntamoxifen\tB-Chemical\n(\tO\n19\tO\n)\tO\narms\tO\n.\tO\n\nThere\tO\nis\tO\na\tO\nstatistically\tO\nsignificant\tO\nreduction\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\namong\tO\nwomen\tO\nreceiving\tO\ntamoxifen\tB-Chemical\nwho\tO\nalso\tO\nused\tO\nhormone\tO\n-\tO\nreplacement\tO\ntherapy\tO\nduring\tO\nthe\tO\ntrial\tO\n:\tO\namong\tO\n390\tO\nwomen\tO\non\tO\nsuch\tO\ntherapy\tO\nand\tO\nallocated\tO\nto\tO\nplacebo\tO\n,\tO\nwe\tO\nfound\tO\neight\tO\ncases\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\ncompared\tO\nwith\tO\none\tO\ncase\tO\namong\tO\n362\tO\nwomen\tO\nallocated\tO\nto\tO\ntamoxifen\tB-Chemical\n.\tO\n\nCompared\tO\nwith\tO\nthe\tO\nplacebo\tO\ngroup\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nsignificantly\tO\nincreased\tO\nrisk\tO\nof\tO\nvascular\tB-Disease\nevents\tI-Disease\nand\tO\nhypertriglyceridaemia\tB-Disease\namong\tO\nwomen\tO\non\tO\ntamoxifen\tB-Chemical\n.\tO\n\nINTERPRETATION\tO\n:\tO\nAlthough\tO\nthis\tO\npreliminary\tO\nanalysis\tO\nhas\tO\nlow\tO\npower\tO\n,\tO\nin\tO\nthis\tO\ncohort\tO\nof\tO\nwomen\tO\nat\tO\nlow\tO\n-\tO\nto\tO\n-\tO\nnormal\tO\nrisk\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\nthe\tO\npostulated\tO\nprotective\tO\neffects\tO\nof\tO\ntamoxifen\tB-Chemical\nare\tO\nnot\tO\nyet\tO\napparent\tO\n.\tO\n\nWomen\tO\nusing\tO\nhormone\tO\n-\tO\nreplacement\tO\ntherapy\tO\nappear\tO\nto\tO\nhave\tO\nbenefited\tO\nfrom\tO\nuse\tO\nof\tO\ntamoxifen\tB-Chemical\n.\tO\n\nThere\tO\nwere\tO\nno\tO\ndeaths\tO\nfrom\tO\nbreast\tB-Disease\ncancer\tI-Disease\nrecorded\tO\nin\tO\nwomen\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nIt\tO\nis\tO\nessential\tO\nto\tO\ncontinue\tO\nfollow\tO\n-\tO\nup\tO\nto\tO\nquantify\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nrisks\tO\nand\tO\nbenefits\tO\nof\tO\ntamoxifen\tB-Chemical\ntherapy\tO\n.\tO\n\nEpileptogenic\tO\nactivity\tO\nof\tO\nfolic\tB-Chemical\nacid\tI-Chemical\nafter\tO\ndrug\tO\ninduces\tO\nSLE\tB-Disease\n(\tO\nfolic\tB-Chemical\nacid\tI-Chemical\nand\tO\nepilepsy\tB-Disease\n)\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nstudy\tO\nthe\tO\neffect\tO\nof\tO\nfolic\tB-Chemical\nacid\tI-Chemical\n-\tO\ncontaining\tO\nmultivitamin\tO\nsupplementation\tO\nin\tO\nepileptic\tB-Disease\nwomen\tO\nbefore\tO\nand\tO\nduring\tO\npregnancy\tO\nin\tO\norder\tO\nto\tO\ndetermine\tO\nthe\tO\nrate\tO\nof\tO\nstructural\tO\nbirth\tB-Disease\ndefects\tI-Disease\nand\tO\nepilepsy\tB-Disease\n-\tO\nrelated\tO\nside\tO\neffects\tO\n.\tO\n\nSTUDY\tO\nDESIGN\tO\n:\tO\nFirst\tO\na\tO\nrandomised\tO\ntrial\tO\n,\tO\nlater\tO\npericonception\tO\ncare\tO\nincluding\tO\nin\tO\ntotal\tO\n12225\tO\nfemales\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOf\tO\n60\tO\nepileptic\tB-Disease\nwomen\tO\nwith\tO\npericonceptional\tO\nfolic\tB-Chemical\nacid\tI-Chemical\n(\tO\n0\tO\n.\tO\n8\tO\nmg\tO\n)\tO\n-\tO\ncontaining\tO\nmultivitamin\tO\nsupplementation\tO\n,\tO\nno\tO\none\tO\ndeveloped\tO\nepilepsy\tB-Disease\n-\tO\nrelated\tO\nside\tO\neffects\tO\nduring\tO\nthe\tO\npericonception\tO\nperiod\tO\n.\tO\n\nOne\tO\nepileptic\tB-Disease\nwoman\tO\ndelivered\tO\na\tO\nnewborn\tO\nwith\tO\ncleft\tB-Disease\nlip\tI-Disease\nand\tI-Disease\npalate\tI-Disease\n.\tO\n\nAnother\tO\npatient\tO\nexhibited\tO\nwith\tO\na\tO\ncluster\tO\nof\tO\nseizures\tB-Disease\nafter\tO\nthe\tO\npericonception\tO\nperiod\tO\nusing\tO\nanother\tO\nmultivitamin\tO\n.\tO\n\nThis\tO\n22\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nepileptic\tB-Disease\nwoman\tO\nwas\tO\ntreated\tO\ncontinuously\tO\nby\tO\ncarbamazepine\tB-Chemical\nand\tO\na\tO\nfolic\tB-Chemical\nacid\tI-Chemical\n(\tO\n1\tO\nmg\tO\n)\tO\n-\tO\ncontaining\tO\nmultivitamin\tO\nfrom\tO\nthe\tO\n20th\tO\nweek\tO\nof\tO\ngestation\tO\n.\tO\n\nShe\tO\ndeveloped\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nand\tO\nlater\tO\nsymptoms\tO\nof\tO\nsystemic\tB-Disease\nlupus\tI-Disease\nerythematodes\tI-Disease\n.\tO\n\nHer\tO\npregnancy\tO\nended\tO\nwith\tO\nstillbirth\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nepileptic\tB-Disease\npregnant\tO\npatient\tO\n'\tO\ns\tO\nautoimmune\tB-Disease\ndisease\tI-Disease\n(\tO\nprobably\tO\ndrug\tO\n-\tO\ninduced\tO\nlupus\tB-Disease\n)\tO\ncould\tO\ndamage\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n,\tO\ntherefore\tO\nthe\tO\ntherapeutic\tO\ndose\tO\n(\tO\n>\tO\nor\tO\n=\tO\n1\tO\nmg\tO\n)\tO\nof\tO\nfolic\tB-Chemical\nacid\tI-Chemical\ntriggered\tO\na\tO\ncluster\tO\nof\tO\nseizures\tB-Disease\n.\tO\n\nPhysiological\tO\ndose\tO\n(\tO\n<\tO\n1\tO\nmg\tO\n)\tO\nof\tO\nfolic\tB-Chemical\nacid\tI-Chemical\nboth\tO\nin\tO\nhealthy\tO\nand\tO\n60\tO\nepileptic\tB-Disease\nwomen\tO\n,\tO\nall\tO\nwithout\tO\nany\tO\nautoimmune\tB-Disease\ndisease\tI-Disease\n,\tO\ndid\tO\nnot\tO\nincrease\tO\nthe\tO\nrisk\tO\nfor\tO\nepileptic\tB-Disease\nseizures\tI-Disease\n.\tO\n\nStroke\tB-Disease\nand\tO\ncocaine\tB-Chemical\nor\tO\namphetamine\tB-Chemical\nuse\tO\n.\tO\n\nThe\tO\nassociation\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\namphetamine\tB-Chemical\nuse\tO\nwith\tO\nhemorrhagic\tO\nand\tO\nischemic\tB-Disease\nstroke\tB-Disease\nis\tO\nbased\tO\nalmost\tO\nsolely\tO\non\tO\ndata\tO\nfrom\tO\ncase\tO\nseries\tO\n.\tO\n\nThe\tO\nlimited\tO\nnumber\tO\nof\tO\nepidemiologic\tO\nstudies\tO\nof\tO\nstroke\tB-Disease\nand\tO\nuse\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\n/\tO\nor\tO\namphetamine\tB-Chemical\nhave\tO\nbeen\tO\ndone\tO\nin\tO\nsettings\tO\nthat\tO\nserve\tO\nmostly\tO\nthe\tO\npoor\tO\nand\tO\n/\tO\nor\tO\nminorities\tO\n.\tO\n\nThis\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nwas\tO\nconducted\tO\nin\tO\nthe\tO\ndefined\tO\npopulation\tO\ncomprising\tO\nmembers\tO\nof\tO\nKaiser\tO\nPermanente\tO\nof\tO\nNorthern\tO\nand\tO\nSouthern\tO\nCalifornia\tO\n.\tO\n\nWe\tO\nattempted\tO\nto\tO\nidentify\tO\nall\tO\nincident\tO\nstrokes\tB-Disease\nin\tO\nwomen\tO\nages\tO\n15\tO\n-\tO\n44\tO\nyears\tO\nduring\tO\na\tO\n3\tO\n-\tO\nyear\tO\nperiod\tO\nusing\tO\nhospital\tO\nadmission\tO\nand\tO\ndischarge\tO\nrecords\tO\n,\tO\nemergency\tO\ndepartment\tO\nlogs\tO\n,\tO\nand\tO\npayment\tO\nrequests\tO\nfor\tO\nout\tO\n-\tO\nof\tO\n-\tO\nplan\tO\nhospitalizations\tO\n.\tO\n\nWe\tO\nselected\tO\ncontrols\tO\n,\tO\nmatched\tO\non\tO\nage\tO\nand\tO\nfacility\tO\nof\tO\nusual\tO\ncare\tO\n,\tO\nat\tO\nrandom\tO\nfrom\tO\nhealthy\tO\nmembers\tO\nof\tO\nthe\tO\nhealth\tO\nplan\tO\n.\tO\n\nWe\tO\nobtained\tO\ninformation\tO\nin\tO\nface\tO\n-\tO\nto\tO\n-\tO\nface\tO\ninterviews\tO\n.\tO\n\nThere\tO\nwere\tO\n347\tO\nconfirmed\tO\nstroke\tB-Disease\ncases\tO\nand\tO\n1\tO\n,\tO\n021\tO\ncontrols\tO\n.\tO\n\nThe\tO\nunivariate\tO\nmatched\tO\nodds\tO\nratio\tO\nfor\tO\nstroke\tB-Disease\nin\tO\nwomen\tO\nwho\tO\nadmitted\tO\nto\tO\nusing\tO\ncocaine\tB-Chemical\nand\tO\n/\tO\nor\tO\namphetamine\tB-Chemical\nwas\tO\n8\tO\n.\tO\n5\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n=\tO\n3\tO\n.\tO\n6\tO\n-\tO\n20\tO\n.\tO\n0\tO\n)\tO\n.\tO\n\nAfter\tO\nfurther\tO\nadjustment\tO\nfor\tO\npotential\tO\nconfounders\tO\n,\tO\nthe\tO\nodds\tO\nratio\tO\nin\tO\nwomen\tO\nwho\tO\nreported\tO\nusing\tO\ncocaine\tB-Chemical\nand\tO\n/\tO\nor\tO\namphetamine\tB-Chemical\nwas\tO\n7\tO\n.\tO\n0\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n=\tO\n2\tO\n.\tO\n8\tO\n-\tO\n17\tO\n.\tO\n9\tO\n)\tO\n.\tO\n\nThe\tO\nuse\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\n/\tO\nor\tO\namphetamine\tB-Chemical\nis\tO\na\tO\nstrong\tO\nrisk\tO\nfactor\tO\nfor\tO\nstroke\tB-Disease\nin\tO\nthis\tO\nsocioeconomically\tO\nheterogeneous\tO\n,\tO\ninsured\tO\nurban\tO\npopulation\tO\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nsubsequent\tO\nto\tO\nthe\tO\nadministration\tO\nof\tO\nrifampicin\tB-Chemical\n.\tO\n\nA\tO\nfollow\tO\n-\tO\nup\tO\nstudy\tO\nof\tO\ncases\tO\nreported\tO\nearlier\tO\n.\tO\n\nA\tO\nclinical\tO\npresentation\tO\nis\tO\nmade\tO\nof\tO\na\tO\n2\tO\n-\tO\n3\tO\nyear\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\nsix\tO\ncases\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nthat\tO\nhave\tO\nbeen\tO\nreported\tO\nearlier\tO\n.\tO\n\nThe\tO\npatients\tO\nhad\tO\ndeveloped\tO\ntransient\tO\nrenal\tB-Disease\nfailure\tI-Disease\nafter\tO\nthe\tO\nintermittent\tO\nadministration\tO\nof\tO\nrifampicin\tB-Chemical\n.\tO\n\nThe\tO\nstage\tO\nof\tO\nolig\tO\n-\tO\nanuria\tB-Disease\nlasted\tO\nfor\tO\n1\tO\n-\tO\n3\tO\nweeks\tO\n,\tO\nand\tO\nfive\tO\nof\tO\nthe\tO\npatients\tO\nwere\tO\ntreated\tO\nby\tO\nhemodialysis\tO\n.\tO\n\nTwo\tO\nof\tO\nthe\tO\npatients\tO\ndied\tO\ndue\tO\nto\tO\nunrelated\tO\ncauses\tO\nduring\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n.\tO\n\nThe\tO\nfour\tO\npatients\tO\nre\tO\n-\tO\nexamined\tO\nwere\tO\nclinically\tO\ncured\tO\n.\tO\n\nPathologic\tO\nfindings\tO\nby\tO\nlight\tO\nmicroscopy\tO\nand\tO\nimmunofluorescence\tO\nat\tO\nbiopsy\tO\nwere\tO\nscarce\tO\n.\tO\n\nNothing\tO\nabnormal\tO\nwas\tO\nseen\tO\nby\tO\nelectron\tO\nmicroscopy\tO\nin\tO\ntwo\tO\nof\tO\nthe\tO\ncases\tO\nstudied\tO\n.\tO\n\nRenal\tO\nfunction\tO\nwas\tO\nnormal\tO\n.\tO\n\nIn\tO\nthree\tO\ncases\tO\nthe\tO\nexcretion\tO\nat\tO\n131I\tO\n-\tO\nhippuran\tO\nrenography\tO\nwas\tO\nslightly\tO\nslowed\tO\n.\tO\n\nAlthough\tO\nin\tO\nthe\tO\nacute\tO\nstage\tO\nthe\tO\nrenal\tB-Disease\nlesions\tI-Disease\nhistologically\tO\nappeared\tO\ntoxic\tO\n,\tO\nevidence\tO\nsuggestive\tO\nof\tO\nan\tO\nimmunological\tO\nmechanism\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nChronic\tO\neffects\tO\nof\tO\na\tO\nnovel\tO\nsynthetic\tO\nanthracycline\tB-Chemical\nderivative\tO\n(\tO\nSM\tB-Chemical\n-\tI-Chemical\n5887\tI-Chemical\n)\tO\non\tO\nnormal\tO\nheart\tO\nand\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\nin\tO\nbeagle\tO\ndogs\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\ninvestigate\tO\nthe\tO\nchronic\tO\ncardiotoxic\tB-Disease\npotential\tO\nof\tO\nSM\tB-Chemical\n-\tI-Chemical\n5887\tI-Chemical\nand\tO\na\tO\npossible\tO\ndeteriorating\tO\neffect\tO\nof\tO\nSM\tB-Chemical\n-\tI-Chemical\n5887\tI-Chemical\non\tO\nlow\tO\n-\tO\ngrade\tO\ncardiotoxicity\tB-Disease\npre\tO\n-\tO\ninduced\tO\nby\tO\ndoxorubicin\tB-Chemical\nin\tO\nbeagle\tO\ndogs\tO\n.\tO\n\nIn\tO\nthe\tO\nchronic\tO\ntreatment\tO\n,\tO\nbeagle\tO\ndogs\tO\nof\tO\neach\tO\nsex\tO\nwere\tO\ngiven\tO\nintravenously\tO\nonce\tO\nevery\tO\n3\tO\nweeks\tO\n,\tO\neither\tO\na\tO\nsublethal\tO\ndose\tO\nof\tO\ndoxorubicin\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nor\tO\nSM\tB-Chemical\n-\tI-Chemical\n5887\tI-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nThe\tO\nexperiment\tO\nwas\tO\nterminated\tO\n3\tO\nweeks\tO\nafter\tO\nthe\tO\nninth\tO\ndosing\tO\n.\tO\n\nAnimals\tO\nwhich\tO\nreceived\tO\nover\tO\nsix\tO\ncourses\tO\nof\tO\ndoxorubicin\tB-Chemical\ndemonstrated\tO\nthe\tO\nelectrocardiogram\tO\n(\tO\nECG\tO\n)\tO\nchanges\tO\n,\tO\ndecrease\tO\nof\tO\nblood\tO\npressure\tO\nand\tO\nhigh\tO\n-\tO\ngrade\tO\nhistopathological\tO\ncardiomyopathy\tB-Disease\n,\tO\nwhile\tO\nanimals\tO\nwhich\tO\nwere\tO\nterminally\tO\nsacrificed\tO\nafter\tO\nthe\tO\nSM\tB-Chemical\n-\tI-Chemical\n5887\tI-Chemical\nadministration\tO\ndid\tO\nnot\tO\nshow\tO\nany\tO\nchanges\tO\nin\tO\nECG\tO\n,\tO\nblood\tO\npressure\tO\nand\tO\nhistopathological\tO\nexaminations\tO\n.\tO\n\nTo\tO\nexamine\tO\na\tO\npossibly\tO\ndeteriorating\tO\ncardiotoxic\tB-Disease\neffect\tO\nof\tO\nSM\tB-Chemical\n-\tI-Chemical\n5887\tI-Chemical\n,\tO\nlow\tO\n-\tO\ngrade\tO\ncardiomyopathy\tB-Disease\nwas\tO\ninduced\tO\nin\tO\ndogs\tO\nby\tO\nfour\tO\ncourses\tO\nof\tO\ndoxorubicin\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nNine\tO\nweeks\tO\nafter\tO\npre\tO\n-\tO\ntreatment\tO\n,\tO\ndogs\tO\nwere\tO\ngiven\tO\nfour\tO\ncourses\tO\nof\tO\neither\tO\ndoxorubicin\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nor\tO\nSM\tB-Chemical\n-\tI-Chemical\n5887\tI-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nonce\tO\nevery\tO\n3\tO\nweeks\tO\n.\tO\n\nThe\tO\nlow\tO\n-\tO\ngrade\tO\ncardiotoxic\tB-Disease\nchanges\tO\nwere\tO\nenhanced\tO\nby\tO\nthe\tO\nadditional\tO\ndoxorubicin\tB-Chemical\ntreatment\tO\n.\tO\n\nOn\tO\nthe\tO\ncontrary\tO\n,\tO\nthe\tO\nSM\tB-Chemical\n-\tI-Chemical\n5887\tI-Chemical\ntreatment\tO\ndid\tO\nnot\tO\nprogress\tO\nthe\tO\ngrade\tO\nof\tO\ncardiomyopathy\tB-Disease\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nSM\tB-Chemical\n-\tI-Chemical\n5887\tI-Chemical\ndoes\tO\nnot\tO\nhave\tO\nany\tO\npotential\tO\nof\tO\nchronic\tO\ncardiotoxicity\tB-Disease\nand\tO\ndeteriorating\tO\neffect\tO\non\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nin\tO\ndogs\tO\n.\tO\n\nRisk\tO\nfor\tO\nvalvular\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\namong\tO\nusers\tO\nof\tO\nfenfluramine\tB-Chemical\nand\tO\ndexfenfluramine\tB-Chemical\nwho\tO\nunderwent\tO\nechocardiography\tO\nbefore\tO\nuse\tO\nof\tO\nmedication\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nBecause\tO\nuncontrolled\tO\nechocardiographic\tO\nsurveys\tO\nsuggested\tO\nthat\tO\nup\tO\nto\tO\n30\tO\n%\tO\nto\tO\n38\tO\n%\tO\nof\tO\nusers\tO\nof\tO\nfenfluramine\tB-Chemical\nand\tO\ndexfenfluramine\tB-Chemical\nhad\tO\nvalvular\tB-Disease\ndisease\tI-Disease\n,\tO\nthese\tO\ndrugs\tO\nwere\tO\nwithdrawn\tO\nfrom\tO\nthe\tO\nmarket\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nrisk\tO\nfor\tO\nnew\tO\nor\tO\nworsening\tO\nvalvular\tB-Disease\nabnormalities\tI-Disease\namong\tO\nusers\tO\nof\tO\nfenfluramine\tB-Chemical\nor\tO\ndexfenfluramine\tB-Chemical\nwho\tO\nunderwent\tO\nechocardiography\tO\nbefore\tO\nthey\tO\nbegan\tO\nto\tO\ntake\tO\nthese\tO\nmedications\tO\n.\tO\n\nDESIGN\tO\n:\tO\nCohort\tO\nstudy\tO\n.\tO\n\nSETTING\tO\n:\tO\nAcademic\tO\nprimary\tO\ncare\tO\npractices\tO\n.\tO\n\nPATIENTS\tO\n:\tO\n46\tO\npatients\tO\nwho\tO\nused\tO\nfenfluramine\tB-Chemical\nor\tO\ndexfenfluramine\tB-Chemical\nfor\tO\n14\tO\ndays\tO\nor\tO\nmore\tO\nand\tO\nhad\tO\nechocardiograms\tO\nobtained\tO\nbefore\tO\ntherapy\tO\n.\tO\n\nMEASUREMENTS\tO\n:\tO\nFollow\tO\n-\tO\nup\tO\nechocardiography\tO\n.\tO\n\nThe\tO\nprimary\tO\noutcome\tO\nwas\tO\nnew\tO\nor\tO\nworsening\tO\nvalvulopathy\tB-Disease\n,\tO\ndefined\tO\nas\tO\nprogression\tO\nof\tO\neither\tO\naortic\tB-Disease\nor\tI-Disease\nmitral\tI-Disease\nregurgitation\tI-Disease\nby\tO\nat\tO\nleast\tO\none\tO\ndegree\tO\nof\tO\nseverity\tO\nand\tO\ndisease\tO\nthat\tO\nmet\tO\nU\tO\n.\tO\nS\tO\n.\tO\n\nFood\tO\nand\tO\nDrug\tO\nAdministration\tO\ncriteria\tO\n(\tO\nat\tO\nleast\tO\nmild\tO\naortic\tB-Disease\nregurgitation\tI-Disease\nor\tO\nmoderate\tO\nmitral\tB-Disease\nregurgitation\tI-Disease\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTwo\tO\npatients\tO\n(\tO\n4\tO\n.\tO\n3\tO\n%\tO\n[\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n0\tO\n.\tO\n6\tO\n%\tO\nto\tO\n14\tO\n.\tO\n8\tO\n%\tO\n]\tO\n)\tO\nreceiving\tO\nfenfluramine\tB-Chemical\n-\tO\nphentermine\tB-Chemical\ndeveloped\tO\nvalvular\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n.\tO\n\nOne\tO\nhad\tO\nbaseline\tO\nbicuspid\tB-Disease\naortic\tI-Disease\nvalve\tI-Disease\nand\tO\nmild\tO\naortic\tB-Disease\nregurgitation\tI-Disease\nthat\tO\nprogressed\tO\nto\tO\nmoderate\tO\nregurgitation\tO\n.\tO\n\nThe\tO\nsecond\tO\npatient\tO\ndeveloped\tO\nnew\tO\nmoderate\tO\naortic\tB-Disease\ninsufficiency\tI-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nUsers\tO\nof\tO\ndiet\tO\nmedications\tO\nare\tO\nat\tO\nrisk\tO\nfor\tO\nvalvular\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nincidence\tO\nmay\tO\nbe\tO\nlower\tO\nthan\tO\nthat\tO\nreported\tO\npreviously\tO\n.\tO\n\nTherapeutic\tO\ndrug\tO\nmonitoring\tO\nof\tO\ntobramycin\tB-Chemical\n:\tO\nonce\tO\n-\tO\ndaily\tO\nversus\tO\ntwice\tO\n-\tO\ndaily\tO\ndosage\tO\nschedules\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\neffect\tO\nof\tO\ndosage\tO\nregimen\tO\n(\tO\nonce\tO\n-\tO\ndaily\tO\nvs\tO\n.\tO\ntwice\tO\n-\tO\ndaily\tO\n)\tO\nof\tO\ntobramicyn\tB-Chemical\non\tO\nsteady\tO\n-\tO\nstate\tO\nserum\tO\nconcentrations\tO\nand\tO\ntoxicity\tB-Disease\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nPatients\tO\nundergoing\tO\ntreatment\tO\nwith\tO\ni\tO\n.\tO\nv\tO\n.\tO\ntobramycin\tB-Chemical\n(\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n)\tO\nwere\tO\nrandomised\tO\nto\tO\ntwo\tO\ngroups\tO\n.\tO\n\nGroup\tO\nOD\tO\n(\tO\nn\tO\n=\tO\n22\tO\n)\tO\nreceived\tO\na\tO\nonce\tO\n-\tO\ndaily\tO\ndose\tO\nof\tO\ntobramycin\tB-Chemical\nand\tO\ngroup\tO\nTD\tO\n(\tO\nn\tO\n=\tO\n21\tO\n)\tO\nreceived\tO\nthe\tO\nsame\tO\ndose\tO\ndivided\tO\ninto\tO\ntwo\tO\ndoses\tO\ndaily\tO\n.\tO\n\nTobramycin\tB-Chemical\nserum\tO\nconcentrations\tO\n(\tO\npeak\tO\nand\tO\ntrough\tO\n)\tO\nwere\tO\nmeasured\tO\nby\tO\nenzyme\tO\nmultiplied\tO\nimmunoassay\tO\n.\tO\n\nThe\tO\nrenal\tO\nand\tO\nauditory\tO\nfunctions\tO\nof\tO\nthe\tO\npatients\tO\nwere\tO\nmonitored\tO\nbefore\tO\n,\tO\nduring\tO\nand\tO\nimmediately\tO\nafter\tO\ntreatment\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\ntwo\tO\ngroups\tO\nwere\tO\ncomparable\tO\nwith\tO\nrespect\tO\nto\tO\nsex\tO\n,\tO\nage\tO\n,\tO\nbody\tO\nweight\tO\nand\tO\nrenal\tO\nfunction\tO\n.\tO\n\nNo\tO\nstatistically\tO\nsignificant\tO\ndifferences\tO\nwere\tO\nfound\tO\nin\tO\nmean\tO\ndaily\tO\ndose\tO\n,\tO\nduration\tO\nof\tO\ntreatment\tO\n,\tO\nor\tO\ncumulative\tO\ndose\tO\n.\tO\n\nTrough\tO\nconcentrations\tO\nwere\tO\n<\tO\n2\tO\ng\tO\n/\tO\nml\tO\nin\tO\nthe\tO\ntwo\tO\ngroups\tO\n(\tO\n100\tO\n%\tO\n)\tO\n.\tO\n\nPeak\tO\nconcentrations\tO\nwere\tO\n>\tO\n6\tO\nmicrog\tO\n/\tO\nml\tO\nin\tO\n100\tO\n%\tO\nof\tO\nthe\tO\nOD\tO\ngroup\tO\nand\tO\nin\tO\n67\tO\n%\tO\nof\tO\nthe\tO\nTD\tO\ngroup\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nMean\tO\npeak\tO\nconcentrations\tO\nwere\tO\nmarkedly\tO\ndifferent\tO\n:\tO\n11\tO\n.\tO\n00\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n89\tO\nmicrog\tO\n/\tO\nml\tO\nin\tO\nOD\tO\nvs\tO\n.\tO\n6\tO\n.\tO\n53\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n45\tO\nmicrog\tO\n/\tO\nml\tO\nin\tO\nTD\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThe\tO\npharmacokinetics\tO\nparameters\tO\nwere\tO\n:\tO\nKe\tO\n,\tO\n(\tO\n0\tO\n.\tO\n15\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n03\tO\n/\tO\nh\tO\nin\tO\nOD\tO\nvs\tO\n.\tO\n0\tO\n.\tO\n24\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n06\tO\n/\tO\nh\tO\nin\tO\nTD\tO\n)\tO\n,\tO\nt1\tO\n/\tO\n2\tO\n,\tO\n(\tO\n4\tO\n.\tO\n95\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n41\tO\nh\tO\nin\tO\nOD\tO\nvs\tO\n.\tO\n3\tO\n.\tO\n07\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n71\tO\nh\tO\nin\tO\nTD\tO\n)\tO\n,\tO\nVd\tO\n(\tO\n0\tO\n.\tO\n35\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n11\tO\nl\tO\n/\tO\nkg\tO\nin\tO\nOD\tO\nvs\tO\n.\tO\n0\tO\n.\tO\n33\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n09\tO\nl\tO\n/\tO\nkg\tO\nin\tO\nTD\tO\n)\tO\n,\tO\nCl\tO\n(\tO\n0\tO\n.\tO\n86\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n29\tO\nml\tO\n/\tO\nmin\tO\n/\tO\nkg\tO\nin\tO\nOD\tO\nvs\tO\n.\tO\n1\tO\n.\tO\n28\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n33\tO\nml\tO\n/\tO\nmin\tO\n/\tO\nkg\tO\nin\tO\nTD\tO\n)\tO\n.\tO\n\nIncreased\tO\nserum\tO\ncreatinine\tB-Chemical\nwas\tO\nobserved\tO\nin\tO\n73\tO\n%\tO\nof\tO\npatients\tO\nin\tO\nOD\tO\nversus\tO\n57\tO\n%\tO\nof\tO\npatients\tO\nin\tO\nTD\tO\n,\tO\nwithout\tO\nevidence\tO\nof\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nIn\tO\nTD\tO\ngroup\tO\n,\tO\nthree\tO\npatients\tO\ndeveloped\tO\ndecreased\tB-Disease\nauditory\tI-Disease\nfunction\tI-Disease\n,\tO\nof\tO\nwhich\tO\none\tO\npresented\tO\nwith\tO\nan\tO\nauditory\tB-Disease\nloss\tI-Disease\nof\tO\n-\tO\n30\tO\ndB\tO\n,\tO\nwhereas\tO\nin\tO\nthe\tO\nOD\tO\ngroup\tO\nonly\tO\none\tO\npatient\tO\npresented\tO\ndecreased\tB-Disease\nauditory\tI-Disease\nfunction\tI-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nsmall\tO\nstudy\tO\nsuggests\tO\nthat\tO\na\tO\nonce\tO\n-\tO\ndaily\tO\ndosing\tO\nregimen\tO\nof\tO\ntobramycin\tB-Chemical\nis\tO\nat\tO\nleast\tO\nas\tO\neffective\tO\nas\tO\nand\tO\nis\tO\nno\tO\nmore\tO\nand\tO\npossibly\tO\nless\tO\ntoxic\tO\nthan\tO\nthe\tO\ntwice\tO\n-\tO\ndaily\tO\nregimen\tO\n.\tO\n\nUsing\tO\na\tO\nsingle\tO\n-\tO\ndose\tO\ntherapy\tO\n,\tO\npeak\tO\nconcentration\tO\ndetermination\tO\nis\tO\nnot\tO\nnecessary\tO\n,\tO\nonly\tO\ntrough\tO\nsamples\tO\nshould\tO\nbe\tO\nmonitored\tO\nto\tO\nensure\tO\nlevels\tO\nbelow\tO\n2\tO\nmicrog\tO\n/\tO\nml\tO\n.\tO\n\nEnhanced\tO\nbradycardia\tB-Disease\ninduced\tO\nby\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\nantagonists\tO\nin\tO\nrats\tO\npretreated\tO\nwith\tO\nisoniazid\tB-Chemical\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\nisoniazid\tB-Chemical\nincrease\tO\nhypotension\tB-Disease\ninduced\tO\nby\tO\nvasodilators\tO\nand\tO\nchange\tO\nthe\tO\naccompanying\tO\nreflex\tO\ntachycardia\tB-Disease\nto\tO\nbradycardia\tB-Disease\n,\tO\nan\tO\ninteraction\tO\nattributed\tO\nto\tO\ndecreased\tO\nsynthesis\tO\nof\tO\nbrain\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n(\tO\nGABA\tB-Chemical\n)\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthe\tO\npossible\tO\nenhancement\tO\nby\tO\nisoniazid\tB-Chemical\nof\tO\nbradycardia\tB-Disease\ninduced\tO\nby\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\nantagonists\tO\nwas\tO\ndetermined\tO\nin\tO\nrats\tO\nanaesthetised\tO\nwith\tO\nchloralose\tB-Chemical\n-\tO\nurethane\tB-Chemical\n.\tO\n\nIsoniazid\tB-Chemical\nsignificantly\tO\nincreased\tO\nbradycardia\tB-Disease\nafter\tO\npropranolol\tB-Chemical\n,\tO\npindolol\tB-Chemical\n,\tO\nlabetalol\tB-Chemical\nand\tO\natenolol\tB-Chemical\n,\tO\nas\tO\nwell\tO\nas\tO\nafter\tO\nclonidine\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nafter\tO\nhexamethonium\tB-Chemical\nor\tO\ncarbachol\tB-Chemical\n.\tO\n\nEnhancement\tO\nwas\tO\nnot\tO\nobserved\tO\nin\tO\nrats\tO\npretreated\tO\nwith\tO\nmethylatropine\tB-Chemical\nor\tO\npreviously\tO\nvagotomised\tO\n.\tO\n\nThese\tO\nresults\tO\nare\tO\ncompatible\tO\nwith\tO\ninterference\tO\nby\tO\nisoniazid\tB-Chemical\nwith\tO\nGABAergic\tO\ninhibition\tO\nof\tO\ncardiac\tO\nparasympathetic\tO\ntone\tO\n.\tO\n\nSuch\tO\ninterference\tO\ncould\tO\nbe\tO\nexerted\tO\ncentrally\tO\n,\tO\npossibly\tO\nat\tO\nthe\tO\nnucleus\tO\nambiguus\tO\n,\tO\nor\tO\nperipherally\tO\nat\tO\nthe\tO\nsinus\tO\nnode\tO\n.\tO\n\nStructural\tB-Disease\nand\tI-Disease\nfunctional\tI-Disease\nimpairment\tI-Disease\nof\tI-Disease\nmitochondria\tI-Disease\nin\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\nin\tO\nmice\tO\n:\tO\nsuppression\tO\nof\tO\ncytochrome\tO\nc\tO\noxidase\tO\nII\tO\ngene\tO\nexpression\tO\n.\tO\n\nThe\tO\nuse\tO\nof\tO\nadriamycin\tB-Chemical\n(\tO\nADR\tB-Chemical\n)\tO\nin\tO\ncancer\tB-Disease\nchemotherapy\tO\nhas\tO\nbeen\tO\nlimited\tO\ndue\tO\nto\tO\nits\tO\ncumulative\tO\ncardiovascular\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nEarlier\tO\nobservations\tO\nthat\tO\nADR\tB-Chemical\ninteracts\tO\nwith\tO\nmitochondrial\tO\ncytochrome\tO\nc\tO\noxidase\tO\n(\tO\nCOX\tO\n)\tO\nand\tO\nsuppresses\tO\nits\tO\nenzyme\tO\nactivity\tO\nled\tO\nus\tO\nto\tO\ninvestigate\tO\nADR\tB-Chemical\n'\tO\ns\tO\naction\tO\non\tO\nthe\tO\ncardiovascular\tO\nfunctions\tO\nand\tO\nheart\tO\nmitochondrial\tO\nmorphology\tO\nin\tO\nBalb\tO\n-\tO\nc\tO\nmice\tO\ni\tO\n.\tO\np\tO\n.\tO\ntreated\tO\nwith\tO\nADR\tB-Chemical\nfor\tO\nseveral\tO\nweeks\tO\n.\tO\n\nAt\tO\nvarious\tO\ntimes\tO\nduring\tO\ntreatment\tO\n,\tO\nthe\tO\nanimals\tO\nwere\tO\nassessed\tO\nfor\tO\ncardiovascular\tO\nfunctions\tO\nby\tO\nelectrocardiography\tO\nand\tO\nfor\tO\nheart\tO\ntissue\tO\ndamage\tO\nby\tO\nelectron\tO\nmicroscopy\tO\n.\tO\n\nIn\tO\nparallel\tO\n,\tO\ntotal\tO\nRNA\tO\nwas\tO\nextracted\tO\nfrom\tO\nsamples\tO\nof\tO\ndissected\tO\nheart\tO\nand\tO\nanalyzed\tO\nby\tO\nNorthern\tO\nblot\tO\nhybridization\tO\nto\tO\ndetermine\tO\nthe\tO\nsteady\tO\n-\tO\nstate\tO\nlevel\tO\nof\tO\nthree\tO\nRNA\tO\ntranscripts\tO\nencoded\tO\nby\tO\nthe\tO\nCOXII\tO\n,\tO\nCOXIII\tO\n,\tO\nand\tO\nCOXIV\tO\ngenes\tO\n.\tO\n\nSimilarly\tO\n,\tO\nsamples\tO\nobtained\tO\nfrom\tO\nthe\tO\nliver\tO\nof\tO\nthe\tO\nsame\tO\nanimals\tO\nwere\tO\nanalyzed\tO\nfor\tO\ncomparative\tO\nstudies\tO\n.\tO\n\nOur\tO\nresults\tO\nindicated\tO\nthat\tO\n1\tO\n)\tO\ntreatment\tO\nof\tO\nmice\tO\nwith\tO\nADR\tB-Chemical\ncaused\tO\ncardiovascular\tB-Disease\narrhythmias\tI-Disease\ncharacterized\tO\nby\tO\nbradycardia\tB-Disease\n,\tO\nextension\tO\nof\tO\nventricular\tO\ndepolarization\tO\ntime\tO\n(\tO\ntQRS\tO\n)\tO\n,\tO\nand\tO\nfailure\tO\nof\tO\nQRS\tO\nat\tO\nhigh\tO\nconcentrations\tO\n(\tO\n10\tO\n-\tO\n14\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\ncumulative\tO\ndose\tO\n)\tO\n;\tO\n2\tO\n)\tO\nthe\tO\nheart\tO\nmitochondria\tO\nunderwent\tO\nswelling\tB-Disease\n,\tO\nfusion\tO\n,\tO\ndissolution\tO\n,\tO\nand\tO\n/\tO\nor\tO\ndisruption\tO\nof\tO\nmitochondrial\tO\ncristae\tO\nafter\tO\nseveral\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nSuch\tO\nabnormalities\tO\nwere\tO\nnot\tO\nobserved\tO\nin\tO\nthe\tO\nmitochondria\tO\nof\tO\nliver\tO\ntissue\tO\n;\tO\nand\tO\n3\tO\n)\tO\namong\tO\nthe\tO\nthree\tO\ngenes\tO\nof\tO\nCOX\tO\nenzyme\tO\nexamined\tO\n,\tO\nonly\tO\nCOXII\tO\ngene\tO\nexpression\tO\nwas\tO\nsuppressed\tO\nby\tO\nADR\tB-Chemical\ntreatment\tO\n,\tO\nmainly\tO\nafter\tO\n8\tO\nweeks\tO\nin\tO\nboth\tO\nheart\tO\nand\tO\nliver\tO\n.\tO\n\nKnowing\tO\nthat\tO\nheart\tO\nmitochondria\tO\nrepresent\tO\nalmost\tO\n40\tO\n%\tO\nof\tO\nheart\tO\nmuscle\tO\nby\tO\nweight\tO\n,\tO\nwe\tO\nconclude\tO\nthat\tO\nthe\tO\ndeteriorating\tO\neffects\tO\nof\tO\nADR\tB-Chemical\non\tO\ncardiovascular\tO\nfunction\tO\ninvolve\tO\nmitochondrial\tB-Disease\nstructural\tI-Disease\nand\tI-Disease\nfunctional\tI-Disease\nimpairment\tI-Disease\n.\tO\n\n"
  },
  {
    "path": "dataset/BC5CDR/test.txt",
    "content": "Torsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nventricular\tB-Disease\ntachycardia\tI-Disease\nduring\tO\nlow\tO\ndose\tO\nintermittent\tO\ndobutamine\tB-Chemical\ntreatment\tO\nin\tO\na\tO\npatient\tO\nwith\tO\ndilated\tB-Disease\ncardiomyopathy\tI-Disease\nand\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n.\tO\n\nThe\tO\nauthors\tO\ndescribe\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n56\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nchronic\tO\n,\tO\nsevere\tO\nheart\tB-Disease\nfailure\tI-Disease\nsecondary\tO\nto\tO\ndilated\tB-Disease\ncardiomyopathy\tI-Disease\nand\tO\nabsence\tO\nof\tO\nsignificant\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\nwho\tO\ndeveloped\tO\nQT\tB-Disease\nprolongation\tI-Disease\nand\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nventricular\tB-Disease\ntachycardia\tI-Disease\nduring\tO\none\tO\ncycle\tO\nof\tO\nintermittent\tO\nlow\tO\ndose\tO\n(\tO\n2\tO\n.\tO\n5\tO\nmcg\tO\n/\tO\nkg\tO\nper\tO\nmin\tO\n)\tO\ndobutamine\tB-Chemical\n.\tO\n\nThis\tO\nreport\tO\nof\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nventricular\tB-Disease\ntachycardia\tI-Disease\nduring\tO\nintermittent\tO\ndobutamine\tB-Chemical\nsupports\tO\nthe\tO\nhypothesis\tO\nthat\tO\nunpredictable\tO\nfatal\tO\narrhythmias\tB-Disease\nmay\tO\noccur\tO\neven\tO\nwith\tO\nlow\tO\ndoses\tO\nand\tO\nin\tO\npatients\tO\nwith\tO\nno\tO\nhistory\tO\nof\tO\nsignificant\tO\nrhythm\tO\ndisturbances\tO\n.\tO\n\nThe\tO\nmechanisms\tO\nof\tO\nproarrhythmic\tO\neffects\tO\nof\tO\nDubutamine\tB-Chemical\nare\tO\ndiscussed\tO\n.\tO\n\nPositive\tO\nskin\tO\ntests\tO\nin\tO\nlate\tO\nreactions\tO\nto\tO\nradiographic\tO\ncontrast\tB-Chemical\nmedia\tI-Chemical\n.\tO\n\nIn\tO\nthe\tO\nlast\tO\nfew\tO\nyears\tO\ndelayed\tO\nreactions\tO\nseveral\tO\nhours\tO\nafter\tO\nthe\tO\ninjection\tO\nof\tO\nradiographic\tO\nand\tO\ncontrast\tB-Chemical\nmaterials\tI-Chemical\n(\tO\nPRC\tB-Chemical\n)\tO\nhave\tO\nbeen\tO\ndescribed\tO\nwith\tO\nincreasing\tO\nfrequency\tO\n.\tO\n\nThe\tO\nauthors\tO\nreport\tO\ntwo\tO\nobservations\tO\non\tO\npatients\tO\nwith\tO\ndelayed\tO\nreactions\tO\nin\tO\nwhom\tO\nintradermoreactions\tO\n(\tO\nIDR\tO\n)\tO\nand\tO\npatch\tO\ntests\tO\nto\tO\na\tO\nseries\tO\nof\tO\nionic\tO\nand\tO\nnon\tO\nionic\tO\nPRC\tB-Chemical\nwere\tO\nstudied\tO\n.\tO\n\nAfter\tO\nangiography\tO\nby\tO\nthe\tO\nvenous\tO\nroute\tO\nin\tO\npatient\tO\nn\tO\ndegree\tO\n1\tO\na\tO\nbiphasic\tO\nreaction\tO\nwith\tO\nan\tO\nimmediate\tO\nreaction\tO\n(\tO\ndyspnea\tB-Disease\n,\tO\nloss\tB-Disease\nof\tI-Disease\nconsciousness\tI-Disease\n)\tO\nand\tO\ndelayed\tO\nmacro\tB-Disease\n-\tI-Disease\npapular\tI-Disease\nrash\tI-Disease\nappeared\tO\n,\tO\nwhilst\tO\npatient\tO\nn\tO\ndegree\tO\n2\tO\ndeveloped\tO\na\tO\ngeneralised\tO\nsensation\tO\nof\tO\nheat\tO\n,\tO\npersistent\tO\npain\tB-Disease\nat\tO\nthe\tO\nsite\tO\nof\tO\ninjection\tO\nimmediately\tO\nand\tO\na\tO\ngeneralised\tO\nmacro\tO\n-\tO\npapular\tO\nreaction\tO\nafter\tO\n24\tO\nhours\tO\n.\tO\n\nThe\tO\nskin\tO\ntests\tO\nrevealed\tO\npositive\tO\ndelayed\tO\nreactions\tO\nof\tO\n24\tO\nhours\tO\nand\tO\n48\tO\nhours\tO\nby\tO\nIDR\tO\nand\tO\npatch\tO\ntests\tO\nto\tO\nonly\tO\nsome\tO\nPRC\tB-Chemical\nwith\tO\ncommon\tO\nchains\tO\nin\tO\ntheir\tO\nstructures\tO\n.\tO\n\nThe\tO\npositive\tO\nskin\tO\ntests\tO\nare\tO\nin\tO\nfavour\tO\nof\tO\nimmunological\tO\nreactions\tO\nand\tO\nmay\tO\nhelp\tO\nin\tO\ndiagnosis\tO\nof\tO\nallergy\tB-Disease\nin\tO\nthe\tO\npatients\tO\n.\tO\n\nRisk\tO\nof\tO\ntransient\tO\nhyperammonemic\tB-Disease\nencephalopathy\tI-Disease\nin\tO\ncancer\tB-Disease\npatients\tO\nwho\tO\nreceived\tO\ncontinuous\tO\ninfusion\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\nwith\tO\nthe\tO\ncomplication\tO\nof\tO\ndehydration\tB-Disease\nand\tO\ninfection\tB-Disease\n.\tO\n\nFrom\tO\n1986\tO\nto\tO\n1998\tO\n,\tO\n29\tO\ncancer\tB-Disease\npatients\tO\nwho\tO\nhad\tO\n32\tO\nepisodes\tO\nof\tO\ntransient\tO\nhyperammonemic\tB-Disease\nencephalopathy\tI-Disease\nrelated\tO\nto\tO\ncontinuous\tO\ninfusion\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\nwere\tO\nidentified\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\npatients\tO\nhad\tO\ndecompensated\tO\nliver\tB-Disease\ndisease\tI-Disease\n.\tO\n\nOnset\tO\nof\tO\nhyperammonemic\tB-Disease\nencephalopathy\tI-Disease\nvaried\tO\nfrom\tO\n0\tO\n.\tO\n5\tO\nto\tO\n5\tO\ndays\tO\n(\tO\nmean\tO\n:\tO\n2\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n3\tO\ndays\tO\n)\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\nchemotherapy\tO\n.\tO\n\nPlasma\tO\nammonium\tB-Chemical\nlevel\tO\nranged\tO\nfrom\tO\n248\tO\nto\tO\n2387\tO\nmicrog\tO\n%\tO\n(\tO\nmean\tO\n:\tO\n626\tO\n+\tO\n/\tO\n-\tO\n431\tO\nmicrog\tO\n%\tO\n)\tO\n.\tO\n\nAmong\tO\nthe\tO\n32\tO\nepisodes\tO\n,\tO\n26\tO\n(\tO\n81\tO\n%\tO\n)\tO\nhad\tO\nvarious\tO\ndegrees\tO\nof\tO\nazotemia\tB-Disease\n,\tO\n18\tO\n(\tO\n56\tO\n%\tO\n)\tO\noccurred\tO\nduring\tO\nbacterial\tB-Disease\ninfections\tI-Disease\nand\tO\n14\tO\n(\tO\n44\tO\n%\tO\n)\tO\nwithout\tO\ninfection\tB-Disease\noccurred\tO\nduring\tO\nperiods\tO\nof\tO\ndehydration\tB-Disease\n.\tO\n\nHigher\tO\nplasma\tO\nammonium\tB-Chemical\nlevels\tO\nand\tO\nmore\tO\nrapid\tO\nonset\tO\nof\tO\nhyperammonemia\tB-Disease\nwere\tO\nseen\tO\nin\tO\n18\tO\npatients\tO\nwith\tO\nbacterial\tB-Disease\ninfections\tI-Disease\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n003\tO\nand\tO\n0\tO\n.\tO\n0006\tO\n,\tO\nrespectively\tO\n)\tO\nand\tO\nin\tO\nnine\tO\npatients\tO\nreceiving\tO\nhigh\tO\ndaily\tO\ndoses\tO\n(\tO\n2600\tO\nor\tO\n1800\tO\nmg\tO\n/\tO\nm2\tO\n)\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n0001\tO\nand\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nIn\tO\n25\tO\nout\tO\nof\tO\n32\tO\nepisodes\tO\n(\tO\n78\tO\n%\tO\n)\tO\n,\tO\nplasma\tO\nammonium\tB-Chemical\nlevels\tO\nand\tO\nmental\tO\nstatus\tO\nreturned\tO\nto\tO\nnormal\tO\nwithin\tO\n2\tO\ndays\tO\nafter\tO\nadequate\tO\nmanagement\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nhyperammonemic\tB-Disease\nencephalopathy\tI-Disease\ncan\tO\noccur\tO\nin\tO\npatients\tO\nreceiving\tO\ncontinuous\tO\ninfusion\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n.\tO\n\nAzotemia\tB-Disease\n,\tO\nbody\tO\nfluid\tO\ninsufficiency\tO\nand\tO\nbacterial\tB-Disease\ninfections\tI-Disease\nwere\tO\nfrequently\tO\nfound\tO\nin\tO\nthese\tO\npatients\tO\n.\tO\n\nIt\tO\nis\tO\ntherefore\tO\nimportant\tO\nto\tO\nrecognize\tO\nthis\tO\ncondition\tO\nin\tO\npatients\tO\nreceiving\tO\ncontinuous\tO\ninfusion\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nquinine\tB-Chemical\nand\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\non\tO\nconditioned\tO\nplace\tO\npreference\tO\nand\tO\nchanges\tO\nin\tO\nmotor\tO\nactivity\tO\ninduced\tO\nby\tO\nmorphine\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\n1\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ntwo\tO\nunselective\tO\npotassium\tB-Chemical\n(\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\n)\tO\nchannel\tO\nblockers\tO\n,\tO\nquinine\tB-Chemical\n(\tO\n12\tO\n.\tO\n5\tO\n,\tO\n25\tO\nand\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\n(\tO\n1\tO\nand\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\non\tO\nconditioned\tO\nplace\tO\npreference\tO\nand\tO\nbiphasic\tO\nchanges\tO\nin\tO\nmotor\tO\nactivity\tO\ninduced\tO\nby\tO\nmorphine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwere\tO\ntested\tO\nin\tO\nWistar\tO\nrats\tO\n.\tO\n\nQuinine\tB-Chemical\nis\tO\nknown\tO\nto\tO\nblock\tO\nvoltage\tO\n-\tO\n,\tO\ncalcium\tB-Chemical\n-\tO\nand\tO\nATP\tB-Chemical\n-\tO\nsensitive\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nchannels\tO\nwhile\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\nis\tO\nknown\tO\nto\tO\nblock\tO\nvoltage\tO\n-\tO\nsensitive\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nchannels\tO\n.\tO\n\n2\tO\n.\tO\n\nIn\tO\nthe\tO\ncounterbalanced\tO\nmethod\tO\n,\tO\nquinine\tB-Chemical\nattenuated\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nplace\tO\npreference\tO\n,\tO\nwhereas\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\nwas\tO\nineffective\tO\n.\tO\n\nIn\tO\nthe\tO\nmotor\tO\nactivity\tO\ntest\tO\nmeasured\tO\nwith\tO\nan\tO\nAnimex\tO\n-\tO\nactivity\tO\nmeter\tO\nneither\tO\nof\tO\nthe\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nchannel\tO\nblockers\tO\naffected\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nhypoactivity\tB-Disease\n,\tO\nbut\tO\nboth\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nchannel\tO\nblockers\tO\nprevented\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nsecondary\tO\nhyperactivity\tB-Disease\n.\tO\n\n3\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthe\tO\ninvolvement\tO\nof\tO\nquinine\tB-Chemical\n-\tO\nsensitive\tO\nbut\tO\nnot\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\n-\tO\nsensitive\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nchannels\tO\nin\tO\nmorphine\tB-Chemical\nreward\tO\n.\tO\n\nIt\tO\nis\tO\nalso\tO\nsuggested\tO\nthat\tO\nthe\tO\nblockade\tO\nof\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nchannels\tO\nsensitive\tO\nto\tO\nthese\tO\nblockers\tO\nis\tO\nnot\tO\nsufficient\tO\nto\tO\nprevent\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nhypoactivity\tB-Disease\nwhereas\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nseems\tO\nto\tO\nbe\tO\nconnected\tO\nto\tO\nboth\tO\nquinine\tB-Chemical\n-\tO\nand\tO\n4\tB-Chemical\n-\tI-Chemical\naminopyridine\tI-Chemical\n-\tO\nsensitive\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nchannels\tO\n.\tO\n\nNociceptin\tB-Chemical\n/\tO\norphanin\tB-Chemical\nFQ\tI-Chemical\nand\tO\nnocistatin\tB-Chemical\non\tO\nlearning\tB-Disease\nand\tI-Disease\nmemory\tI-Disease\nimpairment\tI-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\nin\tO\nmice\tO\n.\tO\n\n1\tO\n.\tO\n\nNociceptin\tB-Chemical\n,\tO\nalso\tO\nknown\tO\nas\tO\norphanin\tB-Chemical\nFQ\tI-Chemical\n,\tO\nis\tO\nan\tO\nendogenous\tO\nligand\tO\nfor\tO\nthe\tO\norphan\tO\nopioid\tO\nreceptor\tO\n-\tO\nlike\tO\nreceptor\tO\n1\tO\n(\tO\nORL1\tO\n)\tO\nand\tO\ninvolves\tO\nin\tO\nvarious\tO\nfunctions\tO\nin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n(\tO\nCNS\tO\n)\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nnocistatin\tB-Chemical\nis\tO\nrecently\tO\nisolated\tO\nfrom\tO\nthe\tO\nsame\tO\nprecursor\tO\nas\tO\nnociceptin\tB-Chemical\nand\tO\nblocks\tO\nnociceptin\tB-Chemical\n-\tO\ninduced\tO\nallodynia\tB-Disease\nand\tO\nhyperalgesia\tB-Disease\n.\tO\n\n2\tO\n.\tO\n\nAlthough\tO\nORL1\tO\nreceptors\tO\nwhich\tO\ndisplay\tO\na\tO\nhigh\tO\ndegree\tO\nof\tO\nsequence\tO\nhomology\tO\nwith\tO\nclassical\tO\nopioid\tO\nreceptors\tO\nare\tO\nabundant\tO\nin\tO\nthe\tO\nhippocampus\tO\n,\tO\nlittle\tO\nis\tO\nknown\tO\nregarding\tO\ntheir\tO\nrole\tO\nin\tO\nlearning\tO\nand\tO\nmemory\tO\n.\tO\n\n3\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\ninvestigate\tO\nwhether\tO\nnociceptin\tB-Chemical\n/\tO\norphanin\tB-Chemical\nFQ\tI-Chemical\nand\tO\nnocistatin\tB-Chemical\ncould\tO\nmodulate\tO\nimpairment\tB-Disease\nof\tI-Disease\nlearning\tI-Disease\nand\tI-Disease\nmemory\tI-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\n,\tO\na\tO\nmuscarinic\tO\ncholinergic\tO\nreceptor\tO\nantagonist\tO\n,\tO\nusing\tO\nspontaneous\tO\nalternation\tO\nof\tO\nY\tO\n-\tO\nmaze\tO\nand\tO\nstep\tO\n-\tO\ndown\tO\ntype\tO\npassive\tO\navoidance\tO\ntasks\tO\nin\tO\nmice\tO\n.\tO\n\n4\tO\n.\tO\n\nWhile\tO\nnocistatin\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\n-\tO\n5\tO\n.\tO\n0\tO\nnmol\tO\nmouse\tO\n-\tO\n1\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\nadministered\tO\n30\tO\nmin\tO\nbefore\tO\nspontaneous\tO\nalternation\tO\nperformance\tO\nor\tO\nthe\tO\ntraining\tO\nsession\tO\nof\tO\nthe\tO\npassive\tO\navoidance\tO\ntask\tO\n,\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nspontaneous\tO\nalternation\tO\nor\tO\npassive\tO\navoidance\tO\nbehaviours\tO\n,\tO\na\tO\nlower\tO\nper\tO\ncent\tO\nalternation\tO\nand\tO\nshorter\tO\nmedian\tO\nstep\tO\n-\tO\ndown\tO\nlatency\tO\nin\tO\nthe\tO\nretention\tO\ntest\tO\nwere\tO\nobtained\tO\nin\tO\nnociceptin\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nand\tO\n/\tO\nor\tO\n5\tO\n.\tO\n0\tO\nnmol\tO\nmouse\tO\n-\tO\n1\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\n-\tO\ntreated\tO\nnormal\tO\nmice\tO\n.\tO\n\n5\tO\n.\tO\n\nAdministration\tO\nof\tO\nnocistatin\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nand\tO\n/\tO\nor\tO\n5\tO\n.\tO\n0\tO\nnmol\tO\nmouse\tO\n-\tO\n1\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\n30\tO\nmin\tO\nbefore\tO\nspontaneous\tO\nalternation\tO\nperformance\tO\nor\tO\nthe\tO\ntraining\tO\nsession\tO\nof\tO\nthe\tO\npassive\tO\navoidance\tO\ntask\tO\n,\tO\nattenuated\tO\nthe\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\nimpairment\tO\nof\tO\nspontaneous\tO\nalternation\tO\nand\tO\npassive\tO\navoidance\tO\nbehaviours\tO\n.\tO\n\n6\tO\n.\tO\n\nThese\tO\nresults\tO\nindicated\tO\nthat\tO\nnocistatin\tB-Chemical\n,\tO\na\tO\nnew\tO\nbiologically\tO\nactive\tO\npeptide\tO\n,\tO\nameliorates\tO\nimpairments\tO\nof\tO\nspontaneous\tO\nalternation\tO\nand\tO\npassive\tO\navoidance\tO\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\n,\tO\nand\tO\nsuggested\tO\nthat\tO\nthese\tO\npeptides\tO\nplay\tO\nopposite\tO\nroles\tO\nin\tO\nlearning\tO\nand\tO\nmemory\tO\n.\tO\n\nMeloxicam\tB-Chemical\n-\tO\ninduced\tO\nliver\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\nfemale\tO\npatient\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\nwho\tO\ndeveloped\tO\nacute\tO\ncytolytic\tO\nhepatitis\tB-Disease\ndue\tO\nto\tO\nmeloxicam\tB-Chemical\n.\tO\n\nRecently\tO\nintroduced\tO\nin\tO\nBelgium\tO\n,\tO\nmeloxicam\tB-Chemical\nis\tO\nthe\tO\nfirst\tO\nnonsteroidal\tO\nantiinflammatory\tO\ndrug\tO\nwith\tO\nselective\tO\naction\tO\non\tO\nthe\tO\ninducible\tO\nform\tO\nof\tO\ncyclooxygenase\tO\n2\tO\n.\tO\n\nThe\tO\nacute\tO\ncytolytic\tO\nhepatitis\tB-Disease\noccurred\tO\nrapidly\tO\nafter\tO\nmeloxicam\tB-Chemical\nadministration\tO\nand\tO\nwas\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nantinuclear\tO\nantibodies\tO\nsuggesting\tO\na\tO\nhypersensitivity\tB-Disease\nmechanism\tO\n.\tO\n\nThis\tO\nfirst\tO\ncase\tO\nof\tO\nmeloxicam\tB-Chemical\nrelated\tO\nliver\tB-Disease\ntoxicity\tI-Disease\ndemonstrates\tO\nthe\tO\npotential\tO\nof\tO\nthis\tO\ndrug\tO\nto\tO\ninduce\tO\nhepatic\tB-Disease\ndamage\tI-Disease\n.\tO\n\nInduction\tO\nof\tO\napoptosis\tO\nby\tO\nremoxipride\tB-Chemical\nmetabolites\tO\nin\tO\nHL60\tO\nand\tO\nCD34\tO\n+\tO\n/\tO\nCD19\tO\n-\tO\nhuman\tO\nbone\tO\nmarrow\tO\nprogenitor\tO\ncells\tO\n:\tO\npotential\tO\nrelevance\tO\nto\tO\nremoxipride\tB-Chemical\n-\tO\ninduced\tO\naplastic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nThe\tO\nantipsychotic\tO\nagent\tO\n,\tO\nremoxipride\tB-Chemical\n[\tO\n(\tB-Chemical\nS\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n-\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nbromo\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n(\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nethyl\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\npyrrolidinyl\tI-Chemical\n)\tI-Chemical\nmethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\ndimethoxybenz\tI-Chemical\namide\tI-Chemical\n]\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nacquired\tO\naplastic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nWe\tO\nhave\tO\nexamined\tO\nthe\tO\nability\tO\nof\tO\nremoxipride\tB-Chemical\n,\tO\nthree\tO\npyrrolidine\tB-Chemical\nring\tO\nmetabolites\tO\nand\tO\nfive\tO\naromatic\tO\nring\tO\nmetabolites\tO\nof\tO\nthe\tO\nparent\tO\ncompound\tO\nto\tO\ninduce\tO\napoptosis\tO\nin\tO\nHL60\tO\ncells\tO\nand\tO\nhuman\tO\nbone\tO\nmarrow\tO\nprogenitor\tO\n(\tO\nHBMP\tO\n)\tO\ncells\tO\n.\tO\n\nCells\tO\nwere\tO\ntreated\tO\nfor\tO\n0\tO\n-\tO\n24\tO\nh\tO\nwith\tO\neach\tO\ncompound\tO\n(\tO\n0\tO\n-\tO\n200\tO\nmicroM\tO\n)\tO\n.\tO\n\nApoptosis\tO\nwas\tO\nassessed\tO\nby\tO\nfluorescence\tO\nmicroscopy\tO\nin\tO\nHoechst\tB-Chemical\n33342\tI-Chemical\n-\tO\nand\tO\npropidium\tB-Chemical\niodide\tI-Chemical\nstained\tO\ncell\tO\nsamples\tO\n.\tO\n\nResults\tO\nwere\tO\nconfirmed\tO\nby\tO\ndetermination\tO\nof\tO\ninternucleosomal\tO\nDNA\tO\nfragmentation\tO\nusing\tO\ngel\tO\nelectrophoresis\tO\nfor\tO\nHL60\tO\ncell\tO\nsamples\tO\nand\tO\nterminal\tO\ndeoxynucleotidyl\tO\ntransferase\tO\nassay\tO\nin\tO\nHBMP\tO\ncells\tO\n.\tO\n\nThe\tO\ncatechol\tB-Chemical\nand\tO\nhydroquinone\tB-Chemical\nmetabolites\tO\n,\tO\nNCQ436\tB-Chemical\nand\tO\nNCQ344\tB-Chemical\n,\tO\ninduced\tO\napoptosis\tO\nin\tO\nHL60\tO\nand\tO\nHBMP\tO\ncells\tO\nin\tO\na\tO\ntime\tO\n-\tO\nand\tO\nconcentration\tO\ndependent\tO\nmanner\tO\n,\tO\nwhile\tO\nthe\tO\nphenols\tB-Chemical\n,\tO\nNCR181\tO\n,\tO\nFLA873\tO\n,\tO\nand\tO\nFLA797\tB-Chemical\n,\tO\nand\tO\nthe\tO\nderivatives\tO\nformed\tO\nby\tO\noxidation\tO\nof\tO\nthe\tO\npyrrolidine\tB-Chemical\nring\tO\n,\tO\nFLA838\tO\n,\tO\nNCM001\tO\n,\tO\nand\tO\nNCL118\tO\n,\tO\nhad\tO\nno\tO\neffect\tO\n.\tO\n\nNo\tO\nnecrosis\tB-Disease\nwas\tO\nobserved\tO\nin\tO\ncells\tO\ntreated\tO\nwith\tO\nNCQ436\tB-Chemical\nbut\tO\nNCQ344\tB-Chemical\nhad\tO\na\tO\nbiphasic\tO\neffect\tO\nin\tO\nboth\tO\ncell\tO\ntypes\tO\n,\tO\ninducing\tO\napoptosis\tO\nat\tO\nlower\tO\nconcentrations\tO\nand\tO\nnecrosis\tB-Disease\nat\tO\nhigher\tO\nconcentrations\tO\n.\tO\n\nThese\tO\ndata\tO\nshow\tO\nthat\tO\nthe\tO\ncatechol\tB-Chemical\nand\tO\nhydroquinone\tB-Chemical\nmetabolites\tO\nof\tO\nremoxipride\tB-Chemical\nhave\tO\ndirect\tO\ntoxic\tO\neffects\tO\nin\tO\nHL60\tO\nand\tO\nHBMP\tO\ncells\tO\n,\tO\nleading\tO\nto\tO\napoptosis\tO\n,\tO\nwhile\tO\nthe\tO\nphenol\tB-Chemical\nmetabolites\tO\nwere\tO\ninactive\tO\n.\tO\n\nSimilarly\tO\n,\tO\nbenzene\tB-Chemical\n-\tO\nderived\tO\ncatechol\tB-Chemical\nand\tO\nhydroquinone\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nphenol\tB-Chemical\n,\tO\ninduce\tO\napoptosis\tO\nin\tO\nHBMP\tO\ncells\tO\n[\tO\nMoran\tO\net\tO\nal\tO\n.\tO\n,\tO\nMol\tO\n.\tO\nPharmacol\tO\n.\tO\n,\tO\n50\tO\n(\tO\n1996\tO\n)\tO\n610\tO\n-\tO\n615\tO\n]\tO\n.\tO\n\nWe\tO\npropose\tO\nthat\tO\nremoxipride\tB-Chemical\nand\tO\nbenzene\tB-Chemical\nmay\tO\ninduce\tO\naplastic\tB-Disease\nanemia\tI-Disease\nvia\tO\nproduction\tO\nof\tO\nsimilar\tO\nreactive\tO\nmetabolites\tO\nand\tO\nthat\tO\nthe\tO\nability\tO\nof\tO\nNCQ436\tB-Chemical\nand\tO\nNCQ344\tB-Chemical\nto\tO\ninduce\tO\napoptosis\tO\nin\tO\nHBMP\tO\ncells\tO\nmay\tO\ncontribute\tO\nto\tO\nthe\tO\nmechanism\tO\nunderlying\tO\nacquired\tO\naplastic\tB-Disease\nanemia\tI-Disease\nthat\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nremoxipride\tB-Chemical\n.\tO\n\nSynthesis\tO\nand\tO\npreliminary\tO\npharmacological\tO\ninvestigations\tO\nof\tO\n1\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ndihydro\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nacenaphthylenyl\tI-Chemical\n)\tI-Chemical\npiperazine\tI-Chemical\nderivatives\tO\nas\tO\npotential\tO\natypical\tO\nantipsychotic\tO\nagents\tO\nin\tO\nmice\tO\n.\tO\n\nIn\tO\nresearch\tO\ntowards\tO\nthe\tO\ndevelopment\tO\nof\tO\nnew\tO\natypical\tO\nantipsychotic\tO\nagents\tO\n,\tO\none\tO\nstrategy\tO\nis\tO\nthat\tO\nthe\tO\ndopaminergic\tO\nsystem\tO\ncan\tO\nbe\tO\nmodulated\tO\nthrough\tO\nmanipulation\tO\nof\tO\nthe\tO\nserotonergic\tO\nsystem\tO\n.\tO\n\nThe\tO\nsynthesis\tO\nand\tO\npreliminary\tO\npharmacological\tO\nevaluation\tO\nof\tO\na\tO\nseries\tO\nof\tO\npotential\tO\natypical\tO\nantipsychotic\tO\nagents\tO\nbased\tO\non\tO\nthe\tO\nstructure\tO\nof\tO\n1\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ndihydro\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nacenaphthylenyl\tI-Chemical\n)\tI-Chemical\npiperazine\tI-Chemical\n(\tO\n7\tO\n)\tO\nis\tO\ndescribed\tO\n.\tO\n\nCompound\tO\n7e\tO\n,\tO\n5\tB-Chemical\n-\tI-Chemical\n{\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ndihydro\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nacenaphthylenyl\tI-Chemical\n)\tI-Chemical\npiperazinyl\tI-Chemical\n]\tI-Chemical\nethyl\tI-Chemical\n}\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\ndihy\tI-Chemical\ndro\tI-Chemical\n-\tI-Chemical\n1H\tI-Chemical\n-\tI-Chemical\nindol\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n,\tO\nfrom\tO\nthis\tO\nseries\tO\nshowed\tO\nsignificant\tO\naffinities\tO\nat\tO\nthe\tO\n5\tO\n-\tO\nHT1A\tO\nand\tO\n5\tO\n-\tO\nHT2A\tO\nreceptors\tO\nand\tO\nmoderate\tO\naffinity\tO\nat\tO\nthe\tO\nD2\tO\nreceptor\tO\n.\tO\n\n7e\tO\nexhibits\tO\na\tO\nhigh\tO\nreversal\tO\nof\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\nindicating\tO\nits\tO\natypical\tO\nantipsychotic\tO\nnature\tO\n.\tO\n\nSub\tO\n-\tO\nchronic\tO\ninhibition\tO\nof\tO\nnitric\tB-Chemical\n-\tI-Chemical\noxide\tI-Chemical\nsynthesis\tO\nmodifies\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nand\tO\nthe\tO\nnumber\tO\nof\tO\nNADPH\tB-Chemical\n-\tO\ndiaphorase\tO\nneurons\tO\nin\tO\nmice\tO\n.\tO\n\nRATIONALE\tO\n:\tO\nNG\tB-Chemical\n-\tI-Chemical\nnitro\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n(\tO\nL\tB-Chemical\n-\tI-Chemical\nNOARG\tI-Chemical\n)\tO\n,\tO\nan\tO\ninhibitor\tO\nof\tO\nnitric\tB-Chemical\n-\tI-Chemical\noxide\tI-Chemical\nsynthase\tO\n(\tO\nNOS\tO\n)\tO\n,\tO\ninduces\tO\ncatalepsy\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nThis\tO\neffect\tO\nundergoes\tO\nrapid\tO\ntolerance\tO\n,\tO\nshowing\tO\na\tO\nsignificant\tO\ndecrease\tO\nafter\tO\n2\tO\ndays\tO\nof\tO\nsub\tO\n-\tO\nchronic\tO\nL\tB-Chemical\n-\tI-Chemical\nNOARG\tI-Chemical\ntreatment\tO\n.\tO\n\nNitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\ninfluence\tO\ndopaminergic\tO\nneurotransmission\tO\nin\tO\nthe\tO\nstriatum\tO\n.\tO\n\nNeuroleptic\tO\ndrugs\tO\nsuch\tO\nas\tO\nhaloperidol\tB-Chemical\n,\tO\nwhich\tO\nblock\tO\ndopamine\tB-Chemical\nreceptors\tO\n,\tO\nalso\tO\ncause\tO\ncatalepsy\tB-Disease\nin\tO\nrodents\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\nsubchronic\tO\nL\tB-Chemical\n-\tI-Chemical\nNOARG\tI-Chemical\ntreatment\tO\nin\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nand\tO\nthe\tO\nnumber\tO\nof\tO\nNOS\tO\nneurons\tO\nin\tO\nareas\tO\nrelated\tO\nto\tO\nmotor\tO\ncontrol\tO\n.\tO\n\nMETHODS\tO\n:\tO\nMale\tO\nalbino\tO\nSwiss\tO\nmice\tO\nwere\tO\ntreated\tO\nsub\tO\n-\tO\nchronically\tO\n(\tO\ntwice\tO\na\tO\nday\tO\nfor\tO\n4\tO\ndays\tO\n)\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\nNOARG\tI-Chemical\n(\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nor\tO\nhaloperidol\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nCatalepsy\tB-Disease\nwas\tO\nevaluated\tO\nat\tO\nthe\tO\nbeginning\tO\nand\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\ntreatments\tO\n.\tO\n\nReduced\tO\nnicotinamide\tB-Chemical\nadenine\tI-Chemical\ndinucleotide\tI-Chemical\nphosphate\tI-Chemical\n-\tO\ndiaphorase\tO\n(\tO\nNADPH\tB-Chemical\n-\tO\nd\tO\n)\tO\nhistochemistry\tO\nwas\tO\nalso\tO\nemployed\tO\nto\tO\nvisualize\tO\nNOS\tO\nas\tO\nan\tO\nindex\tO\nof\tO\nenzyme\tO\nexpression\tO\nin\tO\nmice\tO\nbrain\tO\nregions\tO\nrelated\tO\nto\tO\nmotor\tO\ncontrol\tO\n.\tO\n\nRESULTS\tO\n:\tO\nL\tB-Chemical\n-\tI-Chemical\nNOARG\tI-Chemical\nsub\tO\n-\tO\nchronic\tO\nadministration\tO\nproduced\tO\ntolerance\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\nNOARG\tI-Chemical\nand\tO\nof\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n.\tO\n\nIt\tO\nalso\tO\ninduced\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nNADPH\tB-Chemical\n-\tO\nd\tO\n-\tO\npositive\tO\ncells\tO\nin\tO\nthe\tO\ndorsal\tO\npart\tO\nof\tO\nthe\tO\ncaudate\tO\nand\tO\naccumbens\tO\nnuclei\tO\ncompared\tO\nwith\tO\nhaloperidol\tB-Chemical\nand\tO\nin\tO\nthe\tO\npedunculopontine\tO\ntegmental\tO\nnucleus\tO\ncompared\tO\nwith\tO\nsaline\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthere\tO\nwas\tO\na\tO\ndecrease\tO\nin\tO\nNADPH\tB-Chemical\n-\tO\nd\tO\nneuron\tO\nnumber\tO\nin\tO\nthe\tO\nsubstantia\tO\nnigra\tO\n,\tO\npars\tO\ncompacta\tO\nin\tO\nboth\tO\nhaloperidol\tB-Chemical\n-\tO\ntreated\tO\nand\tO\nL\tB-Chemical\n-\tI-Chemical\nNOARG\tI-Chemical\n-\tO\ntreated\tO\nanimals\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nresults\tO\ngive\tO\nfurther\tO\nsupport\tO\nto\tO\nthe\tO\nhypothesis\tO\nthat\tO\nNO\tB-Chemical\nplays\tO\na\tO\nrole\tO\nin\tO\nmotor\tO\nbehavior\tO\ncontrol\tO\nand\tO\nsuggest\tO\nthat\tO\nit\tO\nmay\tO\ntake\tO\npart\tO\nin\tO\nthe\tO\nsynaptic\tO\nchanges\tO\nproduced\tO\nby\tO\nantipsychotic\tO\ntreatment\tO\n.\tO\n\nProlonged\tO\nleft\tB-Disease\nventricular\tI-Disease\ndysfunction\tI-Disease\noccurs\tO\nin\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nafter\tO\nboth\tO\ndobutamine\tB-Chemical\nand\tO\nexercise\tO\ninduced\tO\nmyocardial\tB-Disease\nischaemia\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndetermine\tO\nwhether\tO\npharmacological\tO\nstress\tO\nleads\tO\nto\tO\nprolonged\tO\nbut\tO\nreversible\tO\nleft\tB-Disease\nventricular\tI-Disease\ndysfunction\tI-Disease\nin\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n,\tO\nsimilar\tO\nto\tO\nthat\tO\nseen\tO\nafter\tO\nexercise\tO\n.\tO\n\nDESIGN\tO\n:\tO\nA\tO\nrandomised\tO\ncrossover\tO\nstudy\tO\nof\tO\nrecovery\tO\ntime\tO\nof\tO\nsystolic\tO\nand\tO\ndiastolic\tO\nleft\tO\nventricular\tO\nfunction\tO\nafter\tO\nexercise\tO\nand\tO\ndobutamine\tB-Chemical\ninduced\tO\nischaemia\tB-Disease\n.\tO\n\nSUBJECTS\tO\n:\tO\n10\tO\npatients\tO\nwith\tO\nstable\tB-Disease\nangina\tI-Disease\n,\tO\nangiographically\tO\nproven\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n,\tO\nand\tO\nnormal\tO\nleft\tO\nventricular\tO\nfunction\tO\n.\tO\n\nINTERVENTIONS\tO\n:\tO\nTreadmill\tO\nexercise\tO\nand\tO\ndobutamine\tB-Chemical\nstress\tO\nwere\tO\nperformed\tO\non\tO\ndifferent\tO\ndays\tO\n.\tO\n\nQuantitative\tO\nassessment\tO\nof\tO\nsystolic\tO\nand\tO\ndiastolic\tO\nleft\tO\nventricular\tO\nfunction\tO\nwas\tO\nperformed\tO\nusing\tO\ntransthoracic\tO\nechocardiography\tO\nat\tO\nbaseline\tO\nand\tO\nat\tO\nregular\tO\nintervals\tO\nafter\tO\neach\tO\ntest\tO\n.\tO\n\nRESULTS\tO\n:\tO\nBoth\tO\nforms\tO\nof\tO\nstress\tO\nled\tO\nto\tO\nprolonged\tO\nbut\tO\nreversible\tO\nsystolic\tO\nand\tO\ndiastolic\tO\ndysfunction\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\ndifference\tO\nin\tO\nthe\tO\nmaximum\tO\ndouble\tO\nproduct\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n53\tO\n)\tO\nor\tO\nST\tO\ndepression\tB-Disease\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n63\tO\n)\tO\nwith\tO\neither\tO\nform\tO\nof\tO\nstress\tO\n.\tO\n\nAfter\tO\nexercise\tO\n,\tO\nejection\tO\nfraction\tO\nwas\tO\nreduced\tO\nat\tO\n15\tO\nand\tO\n30\tO\nminutes\tO\ncompared\tO\nwith\tO\nbaseline\tO\n(\tO\nmean\tO\n(\tO\nSEM\tO\n)\tO\n,\tO\n-\tO\n5\tO\n.\tO\n6\tO\n(\tO\n1\tO\n.\tO\n5\tO\n)\tO\n%\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n;\tO\nand\tO\n-\tO\n6\tO\n.\tO\n1\tO\n(\tO\n2\tO\n.\tO\n2\tO\n)\tO\n%\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nand\tO\nat\tO\n30\tO\nand\tO\n45\tO\nminutes\tO\nafter\tO\ndobutamine\tB-Chemical\n(\tO\n-\tO\n10\tO\n.\tO\n8\tO\n(\tO\n1\tO\n.\tO\n8\tO\n)\tO\n%\tO\nand\tO\n-\tO\n5\tO\n.\tO\n5\tO\n(\tO\n1\tO\n.\tO\n8\tO\n)\tO\n%\tO\n,\tO\nboth\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nRegional\tO\nanalysis\tO\nshowed\tO\na\tO\nreduction\tO\nin\tO\nthe\tO\nworst\tO\naffected\tO\nsegment\tO\n15\tO\nand\tO\n30\tO\nminutes\tO\nafter\tO\nexercise\tO\n(\tO\n-\tO\n27\tO\n.\tO\n9\tO\n(\tO\n7\tO\n.\tO\n2\tO\n)\tO\n%\tO\nand\tO\n-\tO\n28\tO\n.\tO\n6\tO\n(\tO\n5\tO\n.\tO\n7\tO\n)\tO\n%\tO\n,\tO\nboth\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nand\tO\nat\tO\n30\tO\nminutes\tO\nafter\tO\ndobutamine\tB-Chemical\n(\tO\n-\tO\n32\tO\n(\tO\n5\tO\n.\tO\n3\tO\n)\tO\n%\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThe\tO\nisovolumic\tO\nrelaxation\tO\nperiod\tO\nwas\tO\nprolonged\tO\n45\tO\nminutes\tO\nafter\tO\neach\tO\nform\tO\nof\tO\nstress\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n,\tO\ndobutamine\tB-Chemical\ninduced\tO\nischaemia\tB-Disease\nresults\tO\nin\tO\nprolonged\tO\nreversible\tO\nleft\tB-Disease\nventricular\tI-Disease\ndysfunction\tI-Disease\n,\tO\npresumed\tO\nto\tO\nbe\tO\nmyocardial\tB-Disease\nstunning\tI-Disease\n,\tO\nsimilar\tO\nto\tO\nthat\tO\nseen\tO\nafter\tO\nexercise\tO\n.\tO\n\nDobutamine\tB-Chemical\ninduced\tO\nischaemia\tB-Disease\ncould\tO\ntherefore\tO\nbe\tO\nused\tO\nto\tO\nstudy\tO\nthe\tO\npathophysiology\tO\nof\tO\nthis\tO\nphenomenon\tO\nfurther\tO\nin\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n.\tO\n\nAnorexigens\tO\nand\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n:\tO\nresults\tO\nfrom\tO\nthe\tO\nsurveillance\tO\nof\tO\nNorth\tO\nAmerican\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nuse\tO\nof\tO\nappetite\tO\nsuppressants\tO\nin\tO\nEurope\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nprimary\tB-Disease\npulmonary\tI-Disease\nhypertension\tI-Disease\n(\tO\nPPH\tB-Disease\n)\tO\n.\tO\n\nRecently\tO\n,\tO\nfenfluramine\tB-Chemical\nappetite\tO\nsuppressants\tO\nbecame\tO\nwidely\tO\nused\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\nbut\tO\nwere\tO\nwithdrawn\tO\nin\tO\nSeptember\tO\n1997\tO\nbecause\tO\nof\tO\nconcerns\tO\nover\tO\nadverse\tO\neffects\tO\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nWe\tO\nconducted\tO\na\tO\nprospective\tO\nsurveillance\tO\nstudy\tO\non\tO\npatients\tO\ndiagnosed\tO\nwith\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nat\tO\n12\tO\nlarge\tO\nreferral\tO\ncenters\tO\nin\tO\nNorth\tO\nAmerica\tO\n.\tO\n\nData\tO\ncollected\tO\non\tO\npatients\tO\nseen\tO\nfrom\tO\nSeptember\tO\n1\tO\n,\tO\n1996\tO\n,\tO\nto\tO\nDecember\tO\n31\tO\n,\tO\n1997\tO\n,\tO\nincluded\tO\nthe\tO\ncause\tO\nof\tO\nthe\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nand\tO\nits\tO\nseverity\tO\n.\tO\n\nPatients\tO\nwith\tO\nno\tO\nidentifiable\tO\ncause\tO\nof\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nwere\tO\nclassed\tO\nas\tO\nPPH\tB-Disease\n.\tO\n\nA\tO\nhistory\tO\nof\tO\ndrug\tO\nexposure\tO\nalso\tO\nwas\tO\ntaken\tO\nwith\tO\nspecial\tO\nattention\tO\non\tO\nthe\tO\nuse\tO\nof\tO\nantidepressants\tO\n,\tO\nanorexigens\tO\n,\tO\nand\tO\namphetamines\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nFive\tO\nhundred\tO\nseventy\tO\n-\tO\nnine\tO\npatients\tO\nwere\tO\nstudied\tO\n,\tO\n205\tO\nwith\tO\nPPH\tB-Disease\nand\tO\n374\tO\nwith\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nfrom\tO\nother\tO\ncauses\tO\n(\tO\nsecondary\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\n[\tO\nSPH\tO\n]\tO\n)\tO\n.\tO\n\nThe\tO\nuse\tO\nof\tO\nanorexigens\tO\nwas\tO\ncommon\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nHowever\tO\n,\tO\nof\tO\nthe\tO\nmedications\tO\nsurveyed\tO\n,\tO\nonly\tO\nthe\tO\nfenfluramines\tB-Chemical\nhad\tO\na\tO\nsignificant\tO\npreferential\tO\nassociation\tO\nwith\tO\nPPH\tB-Disease\nas\tO\ncompared\tO\nwith\tO\nSPH\tO\n(\tO\nadjusted\tO\nodds\tO\nratio\tO\nfor\tO\nuse\tO\n>\tO\n6\tO\nmonths\tO\n,\tO\n7\tO\n.\tO\n5\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n7\tO\nto\tO\n32\tO\n.\tO\n4\tO\n)\tO\n.\tO\n\nThe\tO\nassociation\tO\nwas\tO\nstronger\tO\nwith\tO\nlonger\tO\nduration\tO\nof\tO\nuse\tO\nwhen\tO\ncompared\tO\nto\tO\nshorter\tO\nduration\tO\nof\tO\nuse\tO\nand\tO\nwas\tO\nmore\tO\npronounced\tO\nin\tO\nrecent\tO\nusers\tO\nthan\tO\nin\tO\nremote\tO\nusers\tO\n.\tO\n\nAn\tO\nunexpectedly\tO\nhigh\tO\n(\tO\n11\tO\n.\tO\n4\tO\n%\tO\n)\tO\nnumber\tO\nof\tO\npatients\tO\nwith\tO\nSPH\tO\nhad\tO\nused\tO\nanorexigens\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nmagnitude\tO\nof\tO\nthe\tO\nassociation\tO\nwith\tO\nPPH\tB-Disease\n,\tO\nthe\tO\nincrease\tO\nof\tO\nassociation\tO\nwith\tO\nincreasing\tO\nduration\tO\nof\tO\nuse\tO\n,\tO\nand\tO\nthe\tO\nspecificity\tO\nfor\tO\nfenfluramines\tB-Chemical\nare\tO\nconsistent\tO\nwith\tO\nprevious\tO\nstudies\tO\nindicating\tO\nthat\tO\nfenfluramines\tB-Chemical\nare\tO\ncausally\tO\nrelated\tO\nto\tO\nPPH\tB-Disease\n.\tO\n\nThe\tO\nhigh\tO\nprevalence\tO\nof\tO\nanorexigen\tO\nuse\tO\nin\tO\npatients\tO\nwith\tO\nSPH\tO\nalso\tO\nraises\tO\nthe\tO\npossibility\tO\nthat\tO\nthese\tO\ndrugs\tO\nprecipitate\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nin\tO\npatients\tO\nwith\tO\nunderlying\tO\nconditions\tO\nassociated\tO\nwith\tO\nSPH\tO\n.\tO\n\nClinical\tO\naspects\tO\nof\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nand\tO\nthrombosis\tB-Disease\nand\tO\nother\tO\nside\tO\neffects\tO\nof\tO\nheparin\tB-Chemical\ntherapy\tO\n.\tO\n\nHeparin\tB-Chemical\n,\tO\nfirst\tO\nused\tO\nto\tO\nprevent\tO\nthe\tO\nclotting\tO\nof\tO\nblood\tO\nin\tO\nvitro\tO\n,\tO\nhas\tO\nbeen\tO\nclinically\tO\nused\tO\nto\tO\ntreat\tO\nthrombosis\tB-Disease\nfor\tO\nmore\tO\nthan\tO\n50\tO\nyears\tO\n.\tO\n\nAlthough\tO\nseveral\tO\nnew\tO\nanticoagulant\tO\ndrugs\tO\nare\tO\nin\tO\ndevelopment\tO\n,\tO\nheparin\tB-Chemical\nremains\tO\nthe\tO\nanticoagulant\tO\nof\tO\nchoice\tO\nto\tO\ntreat\tO\nacute\tO\nthrombotic\tB-Disease\nepisodes\tO\n.\tO\n\nThe\tO\nclinical\tO\neffects\tO\nof\tO\nheparin\tB-Chemical\nare\tO\nmeritorious\tO\n,\tO\nbut\tO\nside\tO\neffects\tO\ndo\tO\nexist\tO\n.\tO\n\nBleeding\tB-Disease\nis\tO\nthe\tO\nprimary\tO\nuntoward\tO\neffect\tO\nof\tO\nheparin\tB-Chemical\n.\tO\n\nMajor\tO\nbleeding\tB-Disease\nis\tO\nof\tO\nprimary\tO\nconcern\tO\nin\tO\npatients\tO\nreceiving\tO\nheparin\tB-Chemical\ntherapy\tO\n.\tO\n\nHowever\tO\n,\tO\nadditional\tO\nimportant\tO\nuntoward\tO\neffects\tO\nof\tO\nheparin\tB-Chemical\ntherapy\tO\ninclude\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n,\tO\nheparin\tB-Chemical\n-\tO\nassociated\tO\nosteoporosis\tB-Disease\n,\tO\neosinophilia\tB-Disease\n,\tO\nskin\tB-Disease\nreactions\tI-Disease\n,\tO\nallergic\tB-Disease\nreactions\tI-Disease\nother\tO\nthan\tO\nthrombocytopenia\tB-Disease\n,\tO\nalopecia\tB-Disease\n,\tO\ntransaminasemia\tO\n,\tO\nhyperkalemia\tB-Disease\n,\tO\nhypoaldosteronism\tB-Disease\n,\tO\nand\tO\npriapism\tB-Disease\n.\tO\n\nThese\tO\nside\tO\neffects\tO\nare\tO\nrelatively\tO\nrare\tO\nin\tO\na\tO\ngiven\tO\nindividual\tO\n,\tO\nbut\tO\ngiven\tO\nthe\tO\nextremely\tO\nwidespread\tO\nuse\tO\nof\tO\nheparin\tB-Chemical\n,\tO\nsome\tO\nare\tO\nquite\tO\ncommon\tO\n,\tO\nparticularly\tO\nHITT\tB-Disease\nand\tO\nosteoporosis\tB-Disease\n.\tO\n\nAlthough\tO\nreasonable\tO\nincidences\tO\nof\tO\nmany\tO\nof\tO\nthese\tO\nside\tO\neffects\tO\ncan\tO\nbe\tO\n\"\tO\nsoftly\tO\n\"\tO\ndeduced\tO\nfrom\tO\ncurrent\tO\nreports\tO\ndealing\tO\nwith\tO\nunfractionated\tO\nheparin\tB-Chemical\n,\tO\nat\tO\npresent\tO\nthe\tO\nincidences\tO\nof\tO\nthese\tO\nside\tO\neffects\tO\nwith\tO\nnewer\tO\nlow\tO\nmolecular\tO\nweight\tO\nheparins\tB-Chemical\nappear\tO\nto\tO\nbe\tO\nmuch\tO\nless\tO\ncommon\tO\n.\tO\n\nHowever\tO\n,\tO\nonly\tO\nlonger\tO\nexperience\tO\nwill\tO\nmore\tO\nclearly\tO\ndefine\tO\nthe\tO\nincidence\tO\nof\tO\neach\tO\nside\tO\neffect\tO\nwith\tO\nlow\tO\nmolecular\tO\nweight\tO\npreparations\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nbilateral\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nin\tO\na\tO\npatient\tO\non\tO\ntacrolimus\tB-Chemical\n(\tO\nFK506\tB-Chemical\n)\tO\ntherapy\tO\nafter\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nbilateral\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nin\tO\na\tO\npatient\tO\nreceiving\tO\ntacrolimus\tB-Chemical\n(\tO\nFK\tB-Chemical\n506\tI-Chemical\n,\tO\nPrograf\tO\n;\tO\nFujisawa\tO\nUSA\tO\n,\tO\nInc\tO\n,\tO\nDeerfield\tO\n,\tO\nIllinois\tO\n)\tO\nfor\tO\nimmunosuppression\tO\nafter\tO\northotropic\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nMETHOD\tO\n:\tO\nCase\tO\nreport\tO\n.\tO\n\nIn\tO\na\tO\n58\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nreceiving\tO\ntacrolimus\tB-Chemical\nafter\tO\northotropic\tO\nliver\tO\ntransplantation\tO\n,\tO\nserial\tO\nneuro\tO\n-\tO\nophthalmologic\tO\nexaminations\tO\nand\tO\nlaboratory\tO\nstudies\tO\nwere\tO\nperformed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\npatient\tO\nhad\tO\nepisodic\tO\ndeterioration\tO\nof\tO\nvision\tO\nin\tO\nboth\tO\neyes\tO\n,\tO\nwith\tO\nclinical\tO\nfeatures\tO\nresembling\tO\nischemic\tB-Disease\noptic\tI-Disease\nneuropathies\tI-Disease\n.\tO\n\nDeterioration\tB-Disease\nof\tI-Disease\nvision\tI-Disease\noccurred\tO\ndespite\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ntacrolimus\tB-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nTacrolimus\tB-Chemical\nand\tO\nother\tO\nimmunosuppressive\tO\nagents\tO\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\noptic\tB-Disease\nnerve\tI-Disease\ntoxicity\tI-Disease\n.\tO\n\nHypercalcemia\tB-Disease\n,\tO\narrhythmia\tB-Disease\n,\tO\nand\tO\nmood\tO\nstabilizers\tO\n.\tO\n\nRecent\tO\nfindings\tO\nin\tO\na\tO\nbipolar\tB-Disease\npatient\tO\nreceiving\tO\nmaintenance\tO\nlithium\tB-Chemical\ntherapy\tO\nwho\tO\ndeveloped\tO\nhypercalcemia\tB-Disease\nand\tO\nsevere\tO\nbradyarrhythmia\tB-Disease\nprompted\tO\nthe\tO\nauthors\tO\nto\tO\nconduct\tO\na\tO\nretrospective\tO\nstudy\tO\nof\tO\nbipolar\tB-Disease\npatients\tO\nwith\tO\nlithium\tB-Chemical\n-\tO\nassociated\tO\nhypercalcemia\tB-Disease\n.\tO\n\nA\tO\nprintout\tO\nof\tO\nall\tO\ncases\tO\nof\tO\nhypercalcemia\tB-Disease\nthat\tO\npresented\tO\nduring\tO\na\tO\n1\tO\n-\tO\nyear\tO\nperiod\tO\nwas\tO\ngenerated\tO\n.\tO\n\nAfter\tO\neliminating\tO\nspurious\tO\nhypercalcemias\tB-Disease\nor\tO\nthose\tO\nassociated\tO\nwith\tO\nintravenous\tO\nfluids\tO\n,\tO\nthe\tO\nauthors\tO\nidentified\tO\n18\tO\nnon\tO\n-\tO\nlithium\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nwith\tO\nhypercalcemias\tB-Disease\nrelated\tO\nto\tO\nmalignancies\tB-Disease\nand\tO\nother\tO\nmedical\tO\nconditions\tO\n(\tO\ngroup\tO\nA\tO\n)\tO\nand\tO\n12\tO\npatients\tO\nwith\tO\nlithium\tB-Chemical\n-\tO\nassociated\tO\nhypercalcemia\tB-Disease\n(\tO\ngroup\tO\nB\tO\n)\tO\n.\tO\n\nPatients\tO\nin\tO\ngroup\tO\nB\tO\nwere\tO\nnot\tO\ncomparable\tO\nto\tO\nthose\tO\nin\tO\ngroup\tO\nA\tO\n,\tO\nas\tO\nthe\tO\nlatter\tO\nwere\tO\nmedically\tO\ncompromised\tO\nand\tO\nwere\tO\nreceiving\tO\nmultiple\tO\npharmacotherapies\tO\n.\tO\n\nThus\tO\n,\tO\ntwo\tO\ncontrol\tO\ngroups\tO\nwere\tO\ngenerated\tO\n:\tO\ngroup\tO\nC1\tO\n,\tO\nwhich\tO\nincluded\tO\nage\tO\n-\tO\nand\tO\nsex\tO\n-\tO\ncomparable\tO\nlithium\tB-Chemical\n-\tO\ntreated\tO\nbipolar\tB-Disease\nnormocalcemic\tO\npatients\tO\n,\tO\nand\tO\ngroup\tO\nC2\tO\n,\tO\nwhich\tO\nincluded\tO\nbipolar\tB-Disease\nnormocalcemic\tO\npatients\tO\ntreated\tO\nwith\tO\nanticonvulsant\tO\nmood\tO\nstabilizers\tO\n.\tO\n\nThe\tO\nelectrocardiographic\tO\n(\tO\nECG\tO\n)\tO\nfindings\tO\nfor\tO\npatients\tO\nin\tO\ngroup\tO\nB\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nof\tO\npatients\tO\nin\tO\ngroups\tO\nC1\tO\nand\tO\nC2\tO\n.\tO\n\nIt\tO\nwas\tO\nfound\tO\nthat\tO\nthese\tO\ngroups\tO\ndid\tO\nnot\tO\ndiffer\tO\nin\tO\ntheir\tO\noverall\tO\nfrequency\tO\nof\tO\nECG\tO\nabnormalities\tO\n;\tO\nhowever\tO\n,\tO\nthere\tO\nwere\tO\nsignificant\tO\ndifferences\tO\nin\tO\nthe\tO\nfrequency\tO\nof\tO\nconduction\tO\ndefects\tO\n.\tO\n\nPatients\tO\nwith\tO\nhypercalcemia\tB-Disease\nresulting\tO\nfrom\tO\nmedical\tO\ndiseases\tO\nand\tO\nbipolar\tB-Disease\npatients\tO\nwith\tO\nlithium\tB-Chemical\n-\tO\nassociated\tO\nhypercalcemia\tB-Disease\nhad\tO\nsignificantly\tO\nhigher\tO\nfrequencies\tO\nof\tO\nconduction\tO\ndefects\tO\n.\tO\n\nPatients\tO\nin\tO\ngroup\tO\nA\tO\nhad\tO\nsignificant\tO\nmortality\tO\nat\tO\n2\tO\n-\tO\nyear\tO\nfollow\tO\n-\tO\nup\tO\n(\tO\n28\tO\n%\tO\n)\tO\n,\tO\nin\tO\ncontrast\tO\nto\tO\nzero\tO\nmortality\tO\nin\tO\nthe\tO\nother\tO\nthree\tO\ngroups\tO\n.\tO\n\nThe\tO\nclinical\tO\nimplications\tO\nof\tO\nthese\tO\nfindings\tO\nare\tO\ndiscussed\tO\n.\tO\n\nAttenuation\tO\nof\tO\nnephrotoxicity\tB-Disease\nby\tO\na\tO\nnovel\tO\nlipid\tO\nnanosphere\tO\n(\tO\nNS\tO\n-\tO\n718\tO\n)\tO\nincorporating\tO\namphotericin\tB-Chemical\nB\tI-Chemical\n.\tO\n\nNS\tO\n-\tO\n718\tO\n,\tO\na\tO\nlipid\tO\nnanosphere\tO\nincorporating\tO\namphotericin\tB-Chemical\nB\tI-Chemical\n,\tO\nis\tO\neffective\tO\nagainst\tO\npathogenic\tO\nfungi\tO\nand\tO\nhas\tO\nlow\tO\ntoxicity\tB-Disease\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\ntoxicity\tB-Disease\nof\tO\nNS\tO\n-\tO\n718\tO\nwith\tO\nthat\tO\nof\tO\nFungizone\tB-Chemical\n(\tO\namphotericin\tB-Chemical\nB\tI-Chemical\n-\tI-Chemical\nsodium\tI-Chemical\ndeoxycholate\tI-Chemical\n;\tO\nD\tB-Chemical\n-\tI-Chemical\nAmB\tI-Chemical\n)\tO\nin\tO\nvitro\tO\nusing\tO\nrenal\tO\ncell\tO\ncultures\tO\nand\tO\nin\tO\nvivo\tO\nby\tO\nbiochemical\tO\nanalysis\tO\n,\tO\nhistopathological\tO\nstudy\tO\nof\tO\nthe\tO\nkidney\tO\nand\tO\npharmacokinetic\tO\nstudy\tO\nof\tO\namphotericin\tB-Chemical\nB\tI-Chemical\nfollowing\tO\nintravenous\tO\ninfusion\tO\nof\tO\nthe\tO\nformulation\tO\nin\tO\nrats\tO\n.\tO\n\nIncubation\tO\nwith\tO\nNS\tO\n-\tO\n718\tO\nresulted\tO\nin\tO\nsignificantly\tO\nless\tO\ndamage\tO\nof\tO\ncultured\tO\nhuman\tO\nrenal\tO\nproximal\tO\ntubular\tO\nepithelial\tO\ncells\tO\ncompared\tO\nwith\tO\nD\tB-Chemical\n-\tI-Chemical\nAmB\tI-Chemical\n.\tO\n\nSerum\tO\nblood\tO\nurea\tB-Chemical\nand\tO\ncreatinine\tB-Chemical\nconcentrations\tO\nincreased\tO\nsignificantly\tO\nin\tO\nrats\tO\ngiven\tO\nan\tO\niv\tO\ninfusion\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\nAmB\tI-Chemical\n3\tO\nmg\tO\n/\tO\nkg\tO\nbut\tO\nnot\tO\nin\tO\nthose\tO\ngiven\tO\nthe\tO\nsame\tO\ndose\tO\nof\tO\nNS\tO\n-\tO\n718\tO\n.\tO\n\nHistopathological\tO\nexamination\tO\nof\tO\nthe\tO\nkidney\tO\nshowed\tO\ntubular\tB-Disease\nnecrosis\tI-Disease\nin\tO\nD\tB-Chemical\n-\tI-Chemical\nAmB\tI-Chemical\n-\tO\ntreated\tO\nrats\tO\nbut\tO\nno\tO\nchange\tO\nin\tO\nNS\tO\n-\tO\n718\tO\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nAmphotericin\tB-Chemical\nB\tI-Chemical\nconcentrations\tO\nin\tO\nthe\tO\nkidney\tO\nin\tO\nNS\tO\n-\tO\n718\tO\n-\tO\ntreated\tO\nrats\tO\nwere\tO\nhigher\tO\nthan\tO\nthose\tO\nin\tO\nD\tB-Chemical\n-\tI-Chemical\nAmB\tI-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nOur\tO\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\nresults\tO\nsuggest\tO\nthat\tO\nincorporation\tO\nof\tO\namphotericin\tB-Chemical\nB\tI-Chemical\ninto\tO\nlipid\tO\nnanospheres\tO\nof\tO\nNS\tO\n-\tO\n718\tO\nattenuates\tO\nthe\tO\nnephrotoxicity\tB-Disease\nof\tO\namphotericin\tB-Chemical\nB\tI-Chemical\n.\tO\n\nPatterns\tO\nof\tO\nsulfadiazine\tB-Chemical\nacute\tB-Disease\nnephrotoxicity\tI-Disease\n.\tO\n\nSulfadiazine\tB-Chemical\nacute\tB-Disease\nnephrotoxicity\tI-Disease\nis\tO\nreviving\tO\nspecially\tO\nbecause\tO\nof\tO\nits\tO\nuse\tO\nin\tO\ntoxoplasmosis\tB-Disease\nin\tO\nHIV\tO\n-\tO\npositive\tO\npatients\tO\n.\tO\n\nWe\tO\nreport\tO\n4\tO\ncases\tO\n,\tO\none\tO\nof\tO\nthem\tO\nin\tO\na\tO\npreviously\tO\nhealthy\tO\nperson\tO\n.\tO\n\nUnder\tO\ntreatment\tO\nwith\tO\nsulfadiazine\tB-Chemical\nthey\tO\ndeveloped\tO\noliguria\tB-Disease\n,\tO\nabdominal\tB-Disease\npain\tI-Disease\n,\tO\nrenal\tB-Disease\nfailure\tI-Disease\nand\tO\nshowed\tO\nmultiple\tO\nradiolucent\tO\nrenal\tB-Disease\ncalculi\tI-Disease\nin\tO\nechography\tO\n.\tO\n\nAll\tO\npatients\tO\nrecovered\tO\ntheir\tO\nprevious\tO\nnormal\tO\nrenal\tO\nfunction\tO\nafter\tO\nadequate\tO\nhydration\tO\nand\tO\nalcalinization\tO\n.\tO\n\nA\tO\nnephrostomy\tO\ntube\tO\nhad\tO\nto\tO\nbe\tO\nplaced\tO\nin\tO\none\tO\nof\tO\nthe\tO\npatients\tO\nfor\tO\nureteral\tB-Disease\nlithiasis\tI-Disease\nin\tO\na\tO\nsingle\tO\nfunctional\tO\nkidney\tO\n.\tO\n\nNone\tO\nof\tO\nthem\tO\nneeded\tO\ndialysis\tO\nor\tO\na\tO\nrenal\tO\nbiopsy\tO\nbecause\tO\nof\tO\na\tO\ntypical\tO\nbenign\tO\ncourse\tO\n.\tO\n\nTreatment\tO\nwith\tO\nsulfadiazine\tB-Chemical\nrequires\tO\nexquisite\tO\ncontrol\tO\nof\tO\nrenal\tO\nfunction\tO\n,\tO\nan\tO\nincrease\tO\nin\tO\nwater\tO\ningestion\tO\nand\tO\npossibly\tO\nthe\tO\nalcalinization\tO\nof\tO\nthe\tO\nurine\tO\n.\tO\n\nWe\tO\ncommunicate\tO\na\tO\ncase\tO\nin\tO\na\tO\npreviously\tO\nhealthy\tO\nperson\tO\n,\tO\na\tO\nfact\tO\nnot\tO\nfound\tO\nin\tO\nthe\tO\nrecent\tO\nliterature\tO\n.\tO\n\nProbably\tO\nmany\tO\nmore\tO\ncases\tO\nare\tO\nnot\tO\ndetected\tO\n.\tO\n\nWe\tO\nthink\tO\nthat\tO\na\tO\nprospective\tO\nstudy\tO\nwould\tO\nbe\tO\nuseful\tO\n.\tO\n\nDownbeat\tB-Disease\nnystagmus\tI-Disease\nassociated\tO\nwith\tO\nintravenous\tO\npatient\tO\n-\tO\ncontrolled\tO\nadministration\tO\nof\tO\nmorphine\tB-Chemical\n.\tO\n\nIMPLICATIONS\tO\n:\tO\nThis\tO\ncase\tO\ndocuments\tO\na\tO\npatient\tO\nwho\tO\ndeveloped\tO\ndizziness\tB-Disease\nwith\tO\ndownbeating\tB-Disease\nnystagmus\tI-Disease\nwhile\tO\nreceiving\tO\na\tO\nrelatively\tO\nlarge\tO\ndose\tO\nof\tO\nIV\tO\npatient\tO\n-\tO\ncontrolled\tO\nanalgesia\tO\nmorphine\tB-Chemical\n.\tO\n\nAlthough\tO\nthere\tO\nhave\tO\nbeen\tO\ncase\tO\nreports\tO\nof\tO\nepidural\tO\nmorphine\tB-Chemical\nwith\tO\nthese\tO\nsymptoms\tO\nand\tO\nsigns\tO\n,\tO\nthis\tO\nhas\tO\nnot\tO\nbeen\tO\npreviously\tO\ndocumented\tO\nwith\tO\nIV\tO\nor\tO\npatient\tO\n-\tO\ncontrolled\tO\nanalgesia\tO\nmorphine\tB-Chemical\n.\tO\n\nHemodynamic\tO\nand\tO\nantiadrenergic\tO\neffects\tO\nof\tO\ndronedarone\tB-Chemical\nand\tO\namiodarone\tB-Chemical\nin\tO\nanimals\tO\nwith\tO\na\tO\nhealed\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nThe\tO\nhemodynamic\tO\nand\tO\nantiadrenergic\tO\neffects\tO\nof\tO\ndronedarone\tB-Chemical\n,\tO\na\tO\nnoniodinated\tO\ncompound\tO\nstructurally\tO\nrelated\tO\nto\tO\namiodarone\tB-Chemical\n,\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nof\tO\namiodarone\tB-Chemical\nafter\tO\nprolonged\tO\noral\tO\nadministration\tO\n,\tO\nboth\tO\nat\tO\nrest\tO\nand\tO\nduring\tO\nsympathetic\tO\nstimulation\tO\nin\tO\nconscious\tO\ndogs\tO\nwith\tO\na\tO\nhealed\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nAll\tO\ndogs\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nrandomly\tO\nreceived\tO\norally\tO\ndronedarone\tB-Chemical\n(\tO\n10\tO\nand\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\namiodarone\tB-Chemical\n(\tO\n10\tO\nand\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nand\tO\nplacebo\tO\ntwice\tO\ndaily\tO\nfor\tO\n7\tO\ndays\tO\n,\tO\nwith\tO\na\tO\n3\tO\n-\tO\nweek\tO\nwashout\tO\nbetween\tO\nconsecutive\tO\ntreatments\tO\n.\tO\n\nHeart\tO\nrate\tO\n(\tO\nHR\tO\n)\tO\n,\tO\nmean\tO\narterial\tO\npressure\tO\n(\tO\nMBP\tO\n)\tO\n,\tO\npositive\tO\nrate\tO\nof\tO\nincrease\tO\nof\tO\nleft\tO\nventricular\tO\npressure\tO\n(\tO\n+\tO\nLVdP\tO\n/\tO\ndt\tO\n)\tO\n,\tO\nechocardiographically\tO\nassessed\tO\nleft\tO\nventricular\tO\nejection\tO\nfraction\tO\n(\tO\nLVEF\tO\n)\tO\n,\tO\nand\tO\nfractional\tO\nshortening\tO\n(\tO\nFS\tO\n)\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nchronotropic\tO\nresponse\tO\nto\tO\nisoproterenol\tB-Chemical\nand\tO\nexercise\tO\n-\tO\ninduced\tO\nsympathetic\tO\nstimulation\tO\nwere\tO\nevaluated\tO\nunder\tO\nbaseline\tO\nand\tO\nposttreatment\tO\nconditions\tO\n.\tO\n\nResting\tO\nvalues\tO\nof\tO\nLVEF\tO\n,\tO\nFS\tO\n,\tO\n+\tO\nLVdP\tO\n/\tO\ndt\tO\n,\tO\nand\tO\nMBP\tO\nremained\tO\nunchanged\tO\nwhatever\tO\nthe\tO\ndrug\tO\nand\tO\nthe\tO\ndosing\tO\nregimen\tO\n,\tO\nwhereas\tO\nresting\tO\nHR\tO\nwas\tO\nsignificantly\tO\nand\tO\ndose\tO\n-\tO\ndependently\tO\nlowered\tO\nafter\tO\ndronedarone\tB-Chemical\nand\tO\nto\tO\na\tO\nlesser\tO\nextent\tO\nafter\tO\namiodarone\tB-Chemical\n.\tO\n\nBoth\tO\ndronedarone\tB-Chemical\nand\tO\namiodarone\tB-Chemical\nsignificantly\tO\nreduced\tO\nthe\tO\nexercise\tO\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nand\tO\n,\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\n,\tO\ndecreased\tO\nthe\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\n.\tO\n\nThus\tO\n,\tO\ndronedarone\tB-Chemical\nand\tO\namiodarone\tB-Chemical\ndisplayed\tO\na\tO\nsimilar\tO\nlevel\tO\nof\tO\nantiadrenergic\tO\neffect\tO\nand\tO\ndid\tO\nnot\tO\nimpair\tO\nthe\tO\nresting\tO\nleft\tO\nventricular\tO\nfunction\tO\n.\tO\n\nConsequently\tO\n,\tO\ndronedarone\tB-Chemical\nmight\tO\nbe\tO\nparticularly\tO\nsuitable\tO\nfor\tO\nthe\tO\ntreatment\tO\nand\tO\nprevention\tO\nof\tO\nvarious\tO\nclinical\tO\narrhythmias\tB-Disease\n,\tO\nwithout\tO\ncompromising\tO\nthe\tO\nleft\tO\nventricular\tO\nfunction\tO\n.\tO\n\nPhase\tO\n2\tO\ntrial\tO\nof\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\n(\tO\n40\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n)\tO\nin\tO\nplatinum\tB-Chemical\n/\tO\npaclitaxel\tB-Chemical\n-\tO\nrefractory\tO\novarian\tB-Disease\nand\tI-Disease\nfallopian\tI-Disease\ntube\tI-Disease\ncancers\tI-Disease\nand\tO\nprimary\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nperitoneum\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nSeveral\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\n(\tO\nDoxil\tB-Chemical\n)\tO\nto\tO\nbe\tO\nan\tO\nactive\tO\nantineoplastic\tO\nagent\tO\nin\tO\nplatinum\tB-Chemical\n-\tO\nresistant\tO\novarian\tB-Disease\ncancer\tI-Disease\n,\tO\nwith\tO\ndose\tO\nlimiting\tO\ntoxicity\tB-Disease\nof\tO\nthe\tO\nstandard\tO\ndosing\tO\nregimen\tO\n(\tO\n50\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nq\tO\n4\tO\nweeks\tO\n)\tO\nbeing\tO\nsevere\tO\nerythrodysesthesia\tB-Disease\n(\tO\n\"\tO\nhand\tB-Disease\n-\tI-Disease\nfoot\tI-Disease\nsyndrome\tI-Disease\n\"\tO\n)\tO\nand\tO\nstomatitis\tB-Disease\n.\tO\n\nWe\tO\nwished\tO\nto\tO\ndevelop\tO\na\tO\nmore\tO\ntolerable\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\ntreatment\tO\nregimen\tO\nand\tO\ndocument\tO\nits\tO\nlevel\tO\nof\tO\nactivity\tO\nin\tO\na\tO\nwell\tO\n-\tO\ndefined\tO\npatient\tO\npopulation\tO\nwith\tO\nplatinum\tB-Chemical\n/\tO\npaclitaxel\tB-Chemical\n-\tO\nrefractory\tO\ndisease\tO\n.\tO\n\nMETHODS\tO\nAND\tO\nMATERIALS\tO\n:\tO\nPatients\tO\nwith\tO\novarian\tB-Disease\nor\tI-Disease\nfallopian\tI-Disease\ntube\tI-Disease\ncancers\tI-Disease\nor\tO\nprimary\tO\nperitoneal\tB-Disease\ncarcinoma\tI-Disease\nwith\tO\nplatinum\tB-Chemical\n/\tO\npaclitaxel\tB-Chemical\n-\tO\nrefractory\tO\ndisease\tO\n(\tO\nstable\tO\nor\tO\nprogressive\tO\ndisease\tO\nfollowing\tO\ntreatment\tO\nwith\tO\nthese\tO\nagents\tO\nor\tO\nprevious\tO\nobjective\tO\nresponse\tO\n<\tO\n3\tO\nmonths\tO\nin\tO\nduration\tO\n)\tO\nwere\tO\ntreated\tO\nwith\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\nat\tO\na\tO\ndose\tO\nof\tO\n40\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nq\tO\n4\tO\nweeks\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n49\tO\npatients\tO\n(\tO\nmedian\tO\nage\tO\n:\tO\n60\tO\n;\tO\nrange\tO\n41\tO\n-\tO\n81\tO\n)\tO\nentered\tO\nthis\tO\nphase\tO\n2\tO\ntrial\tO\n.\tO\n\nThe\tO\nmedian\tO\nnumber\tO\nof\tO\nprior\tO\nregimens\tO\nwas\tO\n2\tO\n(\tO\nrange\tO\n:\tO\n1\tO\n-\tO\n6\tO\n)\tO\n.\tO\n\nSix\tO\n(\tO\n12\tO\n%\tO\n)\tO\nand\tO\n4\tO\n(\tO\n8\tO\n%\tO\n)\tO\npatients\tO\nexperienced\tO\ngrade\tO\n2\tO\nhand\tB-Disease\n-\tI-Disease\nfoot\tI-Disease\nsyndrome\tI-Disease\nand\tO\nstomatitis\tB-Disease\n,\tO\nrespectively\tO\n(\tO\nno\tO\nepisodes\tO\nof\tO\ngrade\tO\n3\tO\n)\tO\n.\tO\n\nOne\tO\npatient\tO\ndeveloped\tO\ngrade\tO\n3\tO\ndiarrhea\tB-Disease\nrequiring\tO\nhospitalization\tO\nfor\tO\nhydration\tO\n.\tO\n\nSix\tO\n(\tO\n12\tO\n%\tO\n)\tO\nindividuals\tO\nrequired\tO\ndose\tO\nreductions\tO\n.\tO\n\nThe\tO\nmedian\tO\nnumber\tO\nof\tO\ncourses\tO\nof\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\nadministered\tO\non\tO\nthis\tO\nprotocol\tO\nwas\tO\n2\tO\n(\tO\nrange\tO\n:\tO\n1\tO\n-\tO\n12\tO\n)\tO\n.\tO\n\nFour\tO\nof\tO\n44\tO\npatients\tO\n(\tO\n9\tO\n%\tO\n)\tO\nevaluable\tO\nfor\tO\nresponse\tO\nexhibited\tO\nobjective\tO\nand\tO\nsubjective\tO\nevidence\tO\nof\tO\nan\tO\nantineoplastic\tO\neffect\tO\nof\tO\ntherapy\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nmodified\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\nregimen\tO\nresults\tO\nin\tO\nless\tO\ntoxicity\tB-Disease\n(\tO\nstomatitis\tB-Disease\n,\tO\nhand\tB-Disease\n-\tI-Disease\nfoot\tI-Disease\nsyndrome\tI-Disease\n)\tO\nthan\tO\nthe\tO\nstandard\tO\nFDA\tO\n-\tO\napproved\tO\ndose\tO\nschedule\tO\n.\tO\n\nDefinite\tO\n,\tO\nalthough\tO\nlimited\tO\n,\tO\nantineoplastic\tO\nactivity\tO\nis\tO\nobserved\tO\nin\tO\npatients\tO\nwith\tO\nwell\tO\n-\tO\ndefined\tO\nplatinum\tB-Chemical\n-\tO\nand\tO\npaclitaxel\tB-Chemical\n-\tO\nrefractory\tO\novarian\tB-Disease\ncancer\tI-Disease\n.\tO\n\nEfficacy\tO\nof\tO\nolanzapine\tB-Chemical\nin\tO\nacute\tO\nbipolar\tB-Disease\nmania\tI-Disease\n:\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\nstudy\tO\n.\tO\n\nThe\tO\nOlanzipine\tB-Chemical\nHGGW\tO\nStudy\tO\nGroup\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nWe\tO\ncompared\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\nolanzapine\tB-Chemical\nvs\tO\nplacebo\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nacute\tO\nbipolar\tB-Disease\nmania\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nFour\tO\n-\tO\nweek\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nparallel\tO\nstudy\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n115\tO\npatients\tO\nwith\tO\na\tO\nDSM\tO\n-\tO\nIV\tO\ndiagnosis\tO\nof\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\n,\tO\nmanic\tB-Disease\nor\tO\nmixed\tO\n,\tO\nwere\tO\nrandomized\tO\nto\tO\nolanzapine\tB-Chemical\n,\tO\n5\tO\nto\tO\n20\tO\nmg\tO\n/\tO\nd\tO\n(\tO\nn\tO\n=\tO\n55\tO\n)\tO\n,\tO\nor\tO\nplacebo\tO\n(\tO\nn\tO\n=\tO\n60\tO\n)\tO\n.\tO\n\nThe\tO\nprimary\tO\nefficacy\tO\nmeasure\tO\nwas\tO\nthe\tO\nYoung\tO\n-\tO\nMania\tB-Disease\nRating\tO\nScale\tO\n(\tO\nY\tO\n-\tO\nMRS\tO\n)\tO\ntotal\tO\nscore\tO\n.\tO\n\nResponse\tO\nand\tO\neuthymia\tO\nwere\tO\ndefined\tO\n,\tO\na\tO\npriori\tO\n,\tO\nas\tO\nat\tO\nleast\tO\na\tO\n50\tO\n%\tO\nimprovement\tO\nfrom\tO\nbaseline\tO\nto\tO\nend\tO\npoint\tO\nand\tO\nas\tO\na\tO\nscore\tO\nof\tO\nno\tO\nless\tO\nthan\tO\n12\tO\nat\tO\nend\tO\npoint\tO\nin\tO\nthe\tO\nY\tO\n-\tO\nMRS\tO\ntotal\tO\nscore\tO\n,\tO\nrespectively\tO\n.\tO\n\nSafety\tO\nwas\tO\nassessed\tO\nusing\tO\nadverse\tO\nevents\tO\n,\tO\nExtrapyramidal\tB-Disease\nSymptom\tI-Disease\n(\tO\nEPS\tB-Disease\n)\tO\nrating\tO\nscales\tO\n,\tO\nlaboratory\tO\nvalues\tO\n,\tO\nelectrocardiograms\tO\n,\tO\nvital\tO\nsigns\tO\n,\tO\nand\tO\nweight\tO\nchange\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOlanzapine\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\ndemonstrated\tO\na\tO\nstatistically\tO\nsignificant\tO\ngreater\tO\nmean\tO\n(\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nimprovement\tO\nin\tO\nY\tO\n-\tO\nMRS\tO\ntotal\tO\nscore\tO\nthan\tO\nplacebo\tO\n-\tO\ntreated\tO\npatients\tO\n(\tO\n-\tO\n14\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n12\tO\n.\tO\n5\tO\nand\tO\n-\tO\n8\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n12\tO\n.\tO\n7\tO\n,\tO\nrespectively\tO\n;\tO\nP\tO\n<\tO\n.\tO\n001\tO\n)\tO\n,\tO\nwhich\tO\nwas\tO\nevident\tO\nat\tO\nthe\tO\nfirst\tO\npostbaseline\tO\nobservation\tO\n1\tO\nweek\tO\nafter\tO\nrandomization\tO\nand\tO\nwas\tO\nmaintained\tO\nthroughout\tO\nthe\tO\nstudy\tO\n(\tO\nlast\tO\nobservation\tO\ncarried\tO\nforward\tO\n)\tO\n.\tO\n\nOlanzapine\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\ndemonstrated\tO\na\tO\nhigher\tO\nrate\tO\nof\tO\nresponse\tO\n(\tO\n65\tO\n%\tO\nvs\tO\n43\tO\n%\tO\n,\tO\nrespectively\tO\n;\tO\nP\tO\n=\tO\n.\tO\n02\tO\n)\tO\nand\tO\neuthymia\tO\n(\tO\n61\tO\n%\tO\nvs\tO\n36\tO\n%\tO\n,\tO\nrespectively\tO\n;\tO\nP\tO\n=\tO\n.\tO\n01\tO\n)\tO\nthan\tO\nplacebo\tO\n-\tO\ntreated\tO\npatients\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nstatistically\tO\nsignificant\tO\ndifferences\tO\nin\tO\nEPSs\tB-Disease\nbetween\tO\ngroups\tO\n.\tO\n\nHowever\tO\n,\tO\nolanzapine\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nhad\tO\na\tO\nstatistically\tO\nsignificant\tO\ngreater\tO\nmean\tO\n(\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nweight\tB-Disease\ngain\tI-Disease\nthan\tO\nplacebo\tO\n-\tO\ntreated\tO\npatients\tO\n(\tO\n2\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n8\tO\nvs\tO\n0\tO\n.\tO\n45\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n3\tO\nkg\tO\n,\tO\nrespectively\tO\n)\tO\nand\tO\nalso\tO\nexperienced\tO\nmore\tO\ntreatment\tO\n-\tO\nemergent\tO\nsomnolence\tB-Disease\n(\tO\n21\tO\npatients\tO\n[\tO\n38\tO\n.\tO\n2\tO\n%\tO\n]\tO\nvs\tO\n5\tO\n[\tO\n8\tO\n.\tO\n3\tO\n%\tO\n]\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOlanzapine\tB-Chemical\ndemonstrated\tO\ngreater\tO\nefficacy\tO\nthan\tO\nplacebo\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nacute\tO\nbipolar\tB-Disease\nmania\tI-Disease\nand\tO\nwas\tO\ngenerally\tO\nwell\tO\ntolerated\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\npupil\tB-Disease\ndilation\tI-Disease\nwith\tO\ntropicamide\tB-Chemical\non\tO\nvision\tO\nand\tO\ndriving\tO\nsimulator\tO\nperformance\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nassess\tO\nthe\tO\neffect\tO\nof\tO\npupil\tB-Disease\ndilation\tI-Disease\non\tO\nvision\tO\nand\tO\ndriving\tO\nability\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nseries\tO\nof\tO\ntests\tO\non\tO\nvarious\tO\nparameters\tO\nof\tO\nvisual\tO\nfunction\tO\nand\tO\ndriving\tO\nsimulator\tO\nperformance\tO\nwere\tO\nperformed\tO\non\tO\n12\tO\nhealthy\tO\ndrivers\tO\n,\tO\nbefore\tO\nand\tO\nafter\tO\npupil\tB-Disease\ndilation\tI-Disease\nusing\tO\nguttae\tO\ntropicamide\tB-Chemical\n1\tO\n%\tO\n.\tO\n\nA\tO\ndriving\tO\nsimulator\tO\n(\tO\nTransport\tO\nResearch\tO\nLaboratory\tO\n)\tO\nwas\tO\nused\tO\nto\tO\nmeasure\tO\nreaction\tO\ntime\tO\n(\tO\nRT\tO\n)\tO\n,\tO\nspeed\tO\nmaintenance\tO\nand\tO\nsteering\tO\naccuracy\tO\n.\tO\n\nTests\tO\nof\tO\nbasic\tO\nvisual\tO\nfunction\tO\nincluded\tO\nhigh\tO\n-\tO\nand\tO\nlow\tO\n-\tO\ncontrast\tO\nvisual\tO\nacuity\tO\n(\tO\nHCVA\tO\nand\tO\nLCVA\tO\n)\tO\n,\tO\nPelli\tO\n-\tO\nRobson\tO\ncontrast\tO\nthreshold\tO\n(\tO\nCT\tO\n)\tO\nand\tO\nGoldmann\tO\nperimetry\tO\n(\tO\nFIELDS\tO\n)\tO\n.\tO\n\nUseful\tO\nField\tO\nof\tO\nView\tO\n(\tO\nUFOV\tO\n-\tO\n-\tO\na\tO\ntest\tO\nof\tO\nvisual\tO\nattention\tO\n)\tO\nwas\tO\nalso\tO\nundertaken\tO\n.\tO\n\nThe\tO\nmean\tO\ndifferences\tO\nin\tO\nthe\tO\npre\tO\n-\tO\nand\tO\npost\tO\n-\tO\ndilatation\tO\nmeasurements\tO\nwere\tO\ntested\tO\nfor\tO\nstatistical\tO\nsignificance\tO\nat\tO\nthe\tO\n95\tO\n%\tO\nlevel\tO\nusing\tO\none\tO\n-\tO\ntail\tO\npaired\tO\nt\tO\n-\tO\ntests\tO\n.\tO\n\nRESULTS\tO\n:\tO\nPupillary\tB-Disease\ndilation\tI-Disease\nresulted\tO\nin\tO\na\tO\nstatistically\tO\nsignificant\tO\ndeterioration\tO\nin\tO\nCT\tO\nand\tO\nHCVA\tO\nonly\tO\n.\tO\n\nFive\tO\nof\tO\n12\tO\ndrivers\tO\nalso\tO\nexhibited\tO\ndeterioration\tO\nin\tO\nLCVA\tO\n,\tO\nCT\tO\nand\tO\nRT\tO\n.\tO\n\nLittle\tO\nevidence\tO\nemerged\tO\nfor\tO\ndeterioration\tO\nin\tO\nFIELDS\tO\nand\tO\nUFOV\tO\n.\tO\n\nAlso\tO\n,\tO\n7\tO\nof\tO\n12\tO\ndrivers\tO\nappeared\tO\nto\tO\nadjust\tO\ntheir\tO\ndriving\tO\nbehaviour\tO\nby\tO\nreducing\tO\ntheir\tO\nspeed\tO\non\tO\nthe\tO\ndriving\tO\nsimulator\tO\n,\tO\nleading\tO\nto\tO\nimproved\tO\nsteering\tO\naccuracy\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPupillary\tB-Disease\ndilation\tI-Disease\nmay\tO\nlead\tO\nto\tO\na\tO\ndecrease\tO\nin\tO\nvision\tO\nand\tO\ndaylight\tO\ndriving\tO\nperformance\tO\nin\tO\nyoung\tO\npeople\tO\n.\tO\n\nA\tO\nlarger\tO\nstudy\tO\n,\tO\nincluding\tO\na\tO\nbroader\tO\nspectrum\tO\nof\tO\nsubjects\tO\n,\tO\nis\tO\nwarranted\tO\nbefore\tO\nguidelines\tO\ncan\tO\nbe\tO\nrecommended\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nisotretinoin\tB-Disease\nembryopathy\tI-Disease\nwith\tO\nbilateral\tO\nanotia\tB-Disease\nand\tO\nTaussig\tB-Disease\n-\tI-Disease\nBing\tI-Disease\nmalformation\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\nnewborn\tO\ninfant\tO\nwith\tO\nmultiple\tO\ncongenital\tO\nanomalies\tO\n(\tO\nanotia\tB-Disease\nand\tO\nTaussig\tB-Disease\n-\tI-Disease\nBing\tI-Disease\nmalformation\tI-Disease\n)\tO\ndue\tO\nto\tO\nexposure\tO\nto\tO\nisotretinoin\tB-Chemical\nwithin\tO\nthe\tO\nfirst\tO\ntrimester\tO\n.\tO\n\nIn\tO\nthis\tO\npaper\tO\nwe\tO\naim\tO\nto\tO\ndraw\tO\nto\tO\nthe\tO\nfact\tO\nthat\tO\ncaution\tO\nis\tO\nneeded\tO\nwhen\tO\nprescribing\tO\nvitamin\tB-Chemical\nA\tI-Chemical\n-\tO\ncontaining\tO\ndrugs\tO\nto\tO\nwomen\tO\nof\tO\nchildbearing\tO\nyears\tO\n.\tO\n\nEffect\tO\nof\tO\nmethoxamine\tB-Chemical\non\tO\nmaximum\tO\nurethral\tO\npressure\tO\nin\tO\nwomen\tO\nwith\tO\ngenuine\tO\nstress\tB-Disease\nincontinence\tI-Disease\n:\tO\na\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\ncrossover\tO\nstudy\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\nevaluate\tO\nthe\tO\npotential\tO\nrole\tO\nfor\tO\na\tO\nselective\tO\nalpha1\tO\n-\tO\nadrenoceptor\tO\nagonist\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nurinary\tB-Disease\nstress\tI-Disease\nincontinence\tI-Disease\n.\tO\n\nA\tO\nrandomised\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ncrossover\tO\nstudy\tO\ndesign\tO\nwas\tO\nemployed\tO\n.\tO\n\nHalf\tO\nlog\tO\nincremental\tO\ndoses\tO\nof\tO\nintravenous\tO\nmethoxamine\tB-Chemical\nor\tO\nplacebo\tO\n(\tO\nsaline\tO\n)\tO\nwere\tO\nadministered\tO\nto\tO\na\tO\ngroup\tO\nof\tO\nwomen\tO\nwith\tO\ngenuine\tO\nstress\tB-Disease\nincontinence\tI-Disease\nwhile\tO\nmeasuring\tO\nmaximum\tO\nurethral\tO\npressure\tO\n(\tO\nMUP\tO\n)\tO\n,\tO\nblood\tO\npressure\tO\n,\tO\nheart\tO\nrate\tO\n,\tO\nand\tO\nsymptomatic\tO\nside\tO\neffects\tO\n.\tO\n\nMethoxamine\tB-Chemical\nevoked\tO\nnon\tO\n-\tO\nsignificant\tO\nincreases\tO\nin\tO\nMUP\tO\nand\tO\ndiastolic\tO\nblood\tO\npressure\tO\nbut\tO\ncaused\tO\na\tB-Disease\nsignificant\tI-Disease\nrise\tI-Disease\nin\tI-Disease\nsystolic\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nand\tO\nsignificant\tO\nfall\tO\nin\tO\nheart\tO\nrate\tO\nat\tO\nmaximum\tO\ndosage\tO\n.\tO\n\nSystemic\tO\nside\tO\neffects\tO\nincluding\tO\npiloerection\tO\n,\tO\nheadache\tB-Disease\n,\tO\nand\tO\ncold\tO\nextremities\tO\nwere\tO\nexperienced\tO\nin\tO\nall\tO\nsubjects\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nthe\tO\nclinical\tO\nusefulness\tO\nof\tO\ndirect\tO\n,\tO\nperipherally\tO\nacting\tO\nsub\tO\n-\tO\ntype\tO\n-\tO\nselective\tO\nalpha1\tO\n-\tO\nadrenoceptor\tO\nagonists\tO\nin\tO\nthe\tO\nmedical\tO\ntreatment\tO\nof\tO\nstress\tB-Disease\nincontinence\tI-Disease\nmay\tO\nbe\tO\nlimited\tO\nby\tO\nassociated\tO\npiloerection\tO\nand\tO\ncardiovascular\tO\nside\tO\neffects\tO\n.\tO\n\nHyperglycemic\tB-Disease\neffect\tO\nof\tO\namino\tB-Chemical\ncompounds\tO\nstructurally\tO\nrelated\tO\nto\tO\ncaproate\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nchronic\tO\nfeeding\tO\nof\tO\nsmall\tO\namounts\tO\n(\tO\n0\tO\n.\tO\n3\tO\n-\tO\n3\tO\n%\tO\nof\tO\ndiet\tO\nweight\tO\n)\tO\nof\tO\ncertain\tO\namino\tB-Chemical\nderivatives\tO\nof\tO\ncaproate\tB-Chemical\nresulted\tO\nin\tO\nhyperglycemia\tB-Disease\n,\tO\nan\tO\nelevated\tO\nglucose\tB-Chemical\ntolerance\tO\ncurve\tO\nand\tO\n,\tO\noccasionally\tO\n,\tO\nglucosuria\tB-Disease\n.\tO\n\nEffective\tO\ncompounds\tO\nincluded\tO\nnorleucine\tB-Chemical\n,\tO\nnorvaline\tB-Chemical\n,\tO\nglutamate\tB-Chemical\n,\tO\nepsilon\tB-Chemical\n-\tI-Chemical\naminocaproate\tI-Chemical\n,\tO\nmethionine\tB-Chemical\n,\tO\nand\tO\nleucine\tB-Chemical\n.\tO\n\nToleration\tO\nof\tO\nhigh\tO\ndoses\tO\nof\tO\nangiotensin\tB-Chemical\n-\tI-Chemical\nconverting\tI-Chemical\nenzyme\tI-Chemical\ninhibitors\tI-Chemical\nin\tO\npatients\tO\nwith\tO\nchronic\tO\nheart\tB-Disease\nfailure\tI-Disease\n:\tO\nresults\tO\nfrom\tO\nthe\tO\nATLAS\tO\ntrial\tO\n.\tO\n\nThe\tO\nAssessment\tO\nof\tO\nTreatment\tO\nwith\tO\nLisinopril\tB-Chemical\nand\tO\nSurvival\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nTreatment\tO\nwith\tO\nangiotensin\tB-Chemical\n-\tI-Chemical\nconverting\tI-Chemical\nenzyme\tI-Chemical\n(\tI-Chemical\nACE\tI-Chemical\n)\tI-Chemical\ninhibitors\tI-Chemical\nreduces\tO\nmortality\tO\nand\tO\nmorbidity\tO\nin\tO\npatients\tO\nwith\tO\nchronic\tO\nheart\tB-Disease\nfailure\tI-Disease\n(\tO\nCHF\tB-Disease\n)\tO\n,\tO\nbut\tO\nmost\tO\naffected\tO\npatients\tO\nare\tO\nnot\tO\nreceiving\tO\nthese\tO\nagents\tO\nor\tO\nare\tO\nbeing\tO\ntreated\tO\nwith\tO\ndoses\tO\nlower\tO\nthan\tO\nthose\tO\nfound\tO\nto\tO\nbe\tO\nefficacious\tO\nin\tO\ntrials\tO\n,\tO\nprimarily\tO\nbecause\tO\nof\tO\nconcerns\tO\nabout\tO\nthe\tO\nsafety\tO\nand\tO\ntolerability\tO\nof\tO\nthese\tO\nagents\tO\n,\tO\nespecially\tO\nat\tO\nthe\tO\nrecommended\tO\ndoses\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nexamines\tO\nthe\tO\nsafety\tO\nand\tO\ntolerability\tO\nof\tO\nhigh\tO\n-\tO\ncompared\tO\nwith\tO\nlow\tO\n-\tO\ndose\tO\nlisinopril\tB-Chemical\nin\tO\nCHF\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nAssessment\tO\nof\tO\nLisinopril\tB-Chemical\nand\tO\nSurvival\tO\nstudy\tO\nwas\tO\na\tO\nmulticenter\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\ntrial\tO\nin\tO\nwhich\tO\npatients\tO\nwith\tO\nor\tO\nwithout\tO\nprevious\tO\nACE\tB-Chemical\ninhibitor\tI-Chemical\ntreatment\tO\nwere\tO\nstabilized\tO\nreceiving\tO\nmedium\tO\n-\tO\ndose\tO\nlisinopril\tB-Chemical\n(\tO\n12\tO\n.\tO\n5\tO\nor\tO\n15\tO\n.\tO\n0\tO\nmg\tO\nonce\tO\ndaily\tO\n[\tO\nOD\tO\n]\tO\n)\tO\nfor\tO\n2\tO\nto\tO\n4\tO\nweeks\tO\nand\tO\nthen\tO\nrandomized\tO\nto\tO\nhigh\tO\n-\tO\n(\tO\n35\tO\n.\tO\n0\tO\nor\tO\n32\tO\n.\tO\n5\tO\nmg\tO\nOD\tO\n)\tO\nor\tO\nlow\tO\n-\tO\ndose\tO\n(\tO\n5\tO\n.\tO\n0\tO\nor\tO\n2\tO\n.\tO\n5\tO\nmg\tO\nOD\tO\n)\tO\ngroups\tO\n.\tO\n\nPatients\tO\nwith\tO\nNew\tO\nYork\tO\nHeart\tO\nAssociation\tO\nclasses\tO\nII\tO\nto\tO\nIV\tO\nCHF\tB-Disease\nand\tO\nleft\tO\nventricular\tO\nejection\tO\nfractions\tO\nof\tO\nno\tO\ngreater\tO\nthan\tO\n0\tO\n.\tO\n30\tO\n(\tO\nn\tO\n=\tO\n3164\tO\n)\tO\nwere\tO\nrandomized\tO\nand\tO\nfollowed\tO\nup\tO\nfor\tO\na\tO\nmedian\tO\nof\tO\n46\tO\nmonths\tO\n.\tO\n\nWe\tO\nexamined\tO\nthe\tO\noccurrence\tO\nof\tO\nadverse\tO\nevents\tO\nand\tO\nthe\tO\nneed\tO\nfor\tO\ndiscontinuation\tO\nand\tO\ndose\tO\nreduction\tO\nduring\tO\ntreatment\tO\n,\tO\nwith\tO\na\tO\nfocus\tO\non\tO\nhypotension\tB-Disease\nand\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nOf\tO\n405\tO\npatients\tO\nnot\tO\npreviously\tO\nreceiving\tO\nan\tO\nACE\tB-Chemical\ninhibitor\tI-Chemical\n,\tO\ndoses\tO\nin\tO\nonly\tO\n4\tO\n.\tO\n2\tO\n%\tO\ncould\tO\nnot\tO\nbe\tO\ntitrated\tO\nto\tO\nthe\tO\nmedium\tO\ndoses\tO\nrequired\tO\nfor\tO\nrandomization\tO\nbecause\tO\nof\tO\nsymptoms\tO\npossibly\tO\nrelated\tO\nto\tO\nhypotension\tB-Disease\n(\tO\n2\tO\n.\tO\n0\tO\n%\tO\n)\tO\nor\tO\nbecause\tO\nof\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\nor\tO\nhyperkalemia\tB-Disease\n(\tO\n2\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nDoses\tO\nin\tO\nmore\tO\nthan\tO\n90\tO\n%\tO\nof\tO\nrandomized\tO\npatients\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\nand\tO\nlow\tO\n-\tO\ndose\tO\ngroups\tO\nwere\tO\ntitrated\tO\nto\tO\ntheir\tO\nassigned\tO\ntarget\tO\n,\tO\nand\tO\nthe\tO\nmean\tO\ndoses\tO\nof\tO\nblinded\tO\nmedication\tO\nin\tO\nboth\tO\ngroups\tO\nremained\tO\nsimilar\tO\nthroughout\tO\nthe\tO\nstudy\tO\n.\tO\n\nWithdrawals\tO\noccurred\tO\nin\tO\n27\tO\n.\tO\n1\tO\n%\tO\nof\tO\nthe\tO\nhigh\tO\n-\tO\nand\tO\n30\tO\n.\tO\n7\tO\n%\tO\nof\tO\nthe\tO\nlow\tO\n-\tO\ndose\tO\ngroups\tO\n.\tO\n\nSubgroups\tO\npresumed\tO\nto\tO\nbe\tO\nat\tO\nhigher\tO\nrisk\tO\nfor\tO\nACE\tB-Chemical\ninhibitor\tI-Chemical\nintolerance\tO\n(\tO\nblood\tO\npressure\tO\n,\tO\n<\tO\n120\tO\nmm\tO\nHg\tO\n;\tO\ncreatinine\tB-Chemical\n,\tO\n>\tO\nor\tO\n=\tO\n132\tO\n.\tO\n6\tO\nmicromol\tO\n/\tO\nL\tO\n[\tO\n>\tO\nor\tO\n=\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndL\tO\n]\tO\n;\tO\nage\tO\n,\tO\n>\tO\nor\tO\n=\tO\n70\tO\nyears\tO\n;\tO\nand\tO\npatients\tO\nwith\tO\ndiabetes\tB-Disease\n)\tO\ngenerally\tO\ntolerated\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\nstrategy\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nfindings\tO\ndemonstrate\tO\nthat\tO\nACE\tB-Chemical\ninhibitor\tI-Chemical\ntherapy\tO\nin\tO\nmost\tO\npatients\tO\nwith\tO\nCHF\tB-Disease\ncan\tO\nbe\tO\nsuccessfully\tO\ntitrated\tO\nto\tO\nand\tO\nmaintained\tO\nat\tO\nhigh\tO\ndoses\tO\n,\tO\nand\tO\nthat\tO\nmore\tO\naggressive\tO\nuse\tO\nof\tO\nthese\tO\nagents\tO\nis\tO\nwarranted\tO\n.\tO\n\nCocaine\tB-Chemical\n,\tO\nethanol\tB-Chemical\n,\tO\nand\tO\ncocaethylene\tB-Chemical\ncardiotoxity\tB-Disease\nin\tO\nan\tO\nanimal\tO\nmodel\tO\nof\tO\ncocaine\tB-Disease\nand\tI-Disease\nethanol\tI-Disease\nabuse\tI-Disease\n.\tO\n\nOBJECTIVES\tO\n:\tO\nSimultaneous\tO\nabuse\tB-Disease\nof\tI-Disease\ncocaine\tI-Disease\nand\tI-Disease\nethanol\tI-Disease\naffects\tO\n12\tO\nmillion\tO\nAmericans\tO\nannually\tO\n.\tO\n\nIn\tO\ncombination\tO\n,\tO\nthese\tO\nsubstances\tO\nare\tO\nsubstantially\tO\nmore\tO\ntoxic\tO\nthan\tO\neither\tO\ndrug\tO\nalone\tO\n.\tO\n\nTheir\tO\ncombined\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nmay\tO\nbe\tO\ndue\tO\nto\tO\nindependent\tO\neffects\tO\nof\tO\neach\tO\ndrug\tO\n;\tO\nhowever\tO\n,\tO\nthey\tO\nmay\tO\nalso\tO\nbe\tO\ndue\tO\nto\tO\ncocaethylene\tB-Chemical\n(\tO\nCE\tB-Chemical\n)\tO\n,\tO\na\tO\ncocaine\tB-Chemical\nmetabolite\tO\nformed\tO\nonly\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nethanol\tB-Chemical\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndelineate\tO\nthe\tO\nrole\tO\nof\tO\nCE\tB-Chemical\nin\tO\nthe\tO\ncombined\tO\ncardiotoxicity\tB-Disease\nof\tO\ncocaine\tB-Chemical\nand\tO\nethanol\tB-Chemical\nin\tO\na\tO\nmodel\tO\nsimulating\tO\ntheir\tO\nabuse\tO\n.\tO\n\nMETHODS\tO\n:\tO\nTwenty\tO\n-\tO\nthree\tO\ndogs\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\neither\tO\n1\tO\n)\tO\nthree\tO\nintravenous\tO\n(\tO\nIV\tO\n)\tO\nboluses\tO\nof\tO\ncocaine\tB-Chemical\n7\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nwith\tO\nethanol\tB-Chemical\n(\tO\n1\tO\ng\tO\n/\tO\nkg\tO\n)\tO\nas\tO\nan\tO\nIV\tO\ninfusion\tO\n(\tO\nC\tO\n+\tO\nE\tO\n,\tO\nn\tO\n=\tO\n8\tO\n)\tO\n,\tO\n2\tO\n)\tO\nthree\tO\ncocaine\tB-Chemical\nboluses\tO\nonly\tO\n(\tO\nC\tO\n,\tO\nn\tO\n=\tO\n6\tO\n)\tO\n,\tO\n3\tO\n)\tO\nethanol\tB-Chemical\ninfusion\tO\nonly\tO\n(\tO\nE\tO\n,\tO\nn\tO\n=\tO\n5\tO\n)\tO\n,\tO\nor\tO\n4\tO\n)\tO\nplacebo\tO\nboluses\tO\nand\tO\ninfusion\tO\n(\tO\nn\tO\n=\tO\n4\tO\n)\tO\n.\tO\n\nHemodynamic\tO\nmeasurements\tO\n,\tO\nelectrocardiograms\tO\n,\tO\nand\tO\nserum\tO\ndrug\tO\nconcentrations\tO\nwere\tO\nobtained\tO\nat\tO\nbaseline\tO\n,\tO\nand\tO\nthen\tO\nat\tO\nfixed\tO\ntime\tO\nintervals\tO\nafter\tO\neach\tO\ndrug\tO\nwas\tO\nadministered\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTwo\tO\nof\tO\neight\tO\ndogs\tO\nin\tO\nthe\tO\nC\tO\n+\tO\nE\tO\ngroup\tO\nexperienced\tO\ncardiovascular\tB-Disease\ncollapse\tI-Disease\n.\tO\n\nThe\tO\nmost\tO\ndramatic\tO\nhemodynamic\tO\nchanges\tO\noccurred\tO\nafter\tO\neach\tO\ncocaine\tB-Chemical\nbolus\tO\nin\tO\nthe\tO\nC\tO\n+\tO\nE\tO\nand\tO\nC\tO\nonly\tO\ngroups\tO\n;\tO\nhowever\tO\n,\tO\npersistent\tO\nhemodynamic\tO\nchanges\tO\noccurred\tO\nin\tO\nthe\tO\nC\tO\n+\tO\nE\tO\ngroup\tO\n.\tO\n\nPeak\tO\nCE\tB-Chemical\nlevels\tO\nwere\tO\nassociated\tO\nwith\tO\na\tO\n45\tO\n%\tO\n(\tO\nSD\tO\n+\tO\n/\tO\n-\tO\n22\tO\n%\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n22\tO\n%\tO\nto\tO\n69\tO\n%\tO\n)\tO\ndecrease\tB-Disease\nin\tI-Disease\ncardiac\tI-Disease\noutput\tI-Disease\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\na\tO\n56\tO\n%\tO\n(\tO\nSD\tO\n+\tO\n/\tO\n-\tO\n23\tO\n%\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n32\tO\n%\tO\nto\tO\n80\tO\n%\tO\n)\tO\ndecrease\tO\nin\tO\ndP\tO\n/\tO\ndt\tO\n(\tO\nmax\tO\n)\tO\n(\tO\np\tO\n<\tO\n.\tO\n006\tO\n)\tO\n,\tO\nand\tO\na\tO\n23\tO\n%\tO\n(\tO\nSD\tO\n+\tO\n/\tO\n-\tO\n15\tO\n%\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n7\tO\n%\tO\nto\tO\n49\tO\n%\tO\n)\tO\ndecrease\tO\nin\tO\nSVO\tO\n(\tO\n2\tO\n)\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nVentricular\tB-Disease\narrhythmias\tI-Disease\nwere\tO\nprimarily\tO\nobserved\tO\nin\tO\nthe\tO\nC\tO\n+\tO\nE\tO\ngroup\tO\n,\tO\nin\tO\nwhich\tO\nfour\tO\nof\tO\neight\tO\ndogs\tO\nexperienced\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCocaine\tB-Chemical\nand\tO\nethanol\tB-Chemical\nin\tO\ncombination\tO\nwere\tO\nmore\tO\ntoxic\tO\nthan\tO\neither\tO\nsubstance\tO\nalone\tO\n.\tO\n\nCo\tO\n-\tO\nadministration\tO\nresulted\tO\nin\tO\nprolonged\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nand\tO\nwas\tO\ndysrhythmogenic\tO\n.\tO\n\nPeak\tO\nserum\tO\ncocaethylene\tB-Chemical\nconcentrations\tO\nwere\tO\nassociated\tO\nwith\tO\nprolonged\tO\nmyocardial\tB-Disease\ndepression\tI-Disease\n.\tO\n\nWorsening\tO\nof\tO\nParkinsonism\tB-Disease\nafter\tO\nthe\tO\nuse\tO\nof\tO\nveralipride\tB-Chemical\nfor\tO\ntreatment\tO\nof\tO\nmenopause\tO\n:\tO\ncase\tO\nreport\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\nfemale\tO\npatient\tO\nwith\tO\nstable\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nwho\tO\nhas\tO\nshown\tO\na\tO\nmarked\tO\nworsening\tO\nof\tO\nher\tO\nmotor\tO\nfunctions\tO\nfollowing\tO\ntherapy\tO\nof\tO\nmenopause\tO\nrelated\tO\nsymptoms\tO\nwith\tO\nveralipride\tB-Chemical\n,\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\nimprovement\tO\nof\tO\nher\tO\nsymptoms\tO\nback\tO\nto\tO\nbaseline\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nWe\tO\nemphasize\tO\nthe\tO\nanti\tO\n-\tO\ndopaminergic\tO\neffect\tO\nof\tO\nveralipride\tB-Chemical\n.\tO\n\nViracept\tB-Chemical\nand\tO\nirregular\tB-Disease\nheartbeat\tI-Disease\nwarning\tO\n.\tO\n\nA\tO\ngroup\tO\nof\tO\ndoctors\tO\nin\tO\nBoston\tO\nwarn\tO\nthat\tO\nthe\tO\nprotease\tO\ninhibitor\tO\nViracept\tB-Chemical\nmay\tO\ncause\tO\nan\tO\nirregular\tB-Disease\nheart\tI-Disease\nbeat\tI-Disease\n,\tO\nknown\tO\nas\tO\nbradycardia\tB-Disease\n,\tO\nin\tO\npeople\tO\nwith\tO\nHIV\tO\n.\tO\n\nBradycardia\tB-Disease\noccurred\tO\nin\tO\na\tO\n45\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\npatient\tO\nwho\tO\nwas\tO\nViracept\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nother\tO\nanti\tO\n-\tO\nHIV\tO\ndrugs\tO\n.\tO\n\nThe\tO\nsymptoms\tO\nceased\tO\nafter\tO\nswitching\tO\nto\tO\nanother\tO\ndrug\tO\ncombination\tO\n.\tO\n\nFrequency\tO\nof\tO\nappearance\tO\nof\tO\nmyeloperoxidase\tO\n-\tO\nantineutrophil\tO\ncytoplasmic\tO\nantibody\tO\n(\tO\nMPO\tO\n-\tO\nANCA\tO\n)\tO\nin\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\npatients\tO\ntreated\tO\nwith\tO\npropylthiouracil\tB-Chemical\nand\tO\nthe\tO\nrelationship\tO\nbetween\tO\nMPO\tO\n-\tO\nANCA\tO\nand\tO\nclinical\tO\nmanifestations\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nMyeloperoxidase\tO\nantineutrophil\tO\ncytoplasmic\tO\nantibody\tO\n(\tO\nMPO\tO\n-\tO\nANCA\tO\n)\tO\n-\tO\npositive\tO\nvasculitis\tB-Disease\nhas\tO\nbeen\tO\nreported\tO\nin\tO\npatients\tO\nwith\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\nwho\tO\nwere\tO\ntreated\tO\nwith\tO\npropylthiouracil\tB-Chemical\n(\tO\nPTU\tB-Chemical\n)\tO\n.\tO\n\nThe\tO\nappearance\tO\nof\tO\nMPO\tO\n-\tO\nANCA\tO\nin\tO\nthese\tO\ncases\tO\nwas\tO\nsuspected\tO\nof\tO\nbeing\tO\nrelated\tO\nto\tO\nPTU\tB-Chemical\nbecause\tO\nthe\tO\ntitres\tO\nof\tO\nMPO\tO\n-\tO\nANCA\tO\ndecreased\tO\nwhen\tO\nPTU\tB-Chemical\nwas\tO\nstopped\tO\n.\tO\n\nNevertheless\tO\n,\tO\nthere\tO\nhave\tO\nbeen\tO\nno\tO\nstudies\tO\non\tO\nthe\tO\ntemporal\tO\nrelationship\tO\nbetween\tO\nthe\tO\nappearance\tO\nof\tO\nMPO\tO\n-\tO\nANCA\tO\nand\tO\nvasculitis\tB-Disease\nduring\tO\nPTU\tB-Chemical\ntherapy\tO\n,\tO\nor\tO\non\tO\nthe\tO\nincidence\tO\nof\tO\nMPO\tO\n-\tO\nANCA\tO\nin\tO\nuntreated\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\npatients\tO\n.\tO\n\nTherefore\tO\n,\tO\nwe\tO\nsought\tO\nto\tO\naddress\tO\nthese\tO\nparameters\tO\nin\tO\npatients\tO\nwith\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\n.\tO\n\nPATIENTS\tO\n:\tO\nWe\tO\ninvestigated\tO\n102\tO\nuntreated\tO\npatients\tO\nwith\tO\nhyperthyroidism\tB-Disease\ndue\tO\nto\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\nfor\tO\nthe\tO\npresence\tO\nof\tO\nMPO\tO\n-\tO\nANCA\tO\n,\tO\nand\tO\nfor\tO\nthe\tO\ndevelopment\tO\nvasculitis\tB-Disease\nafter\tO\nstarting\tO\nPTU\tB-Chemical\ntherapy\tO\n.\tO\n\nTwenty\tO\n-\tO\nnine\tO\nof\tO\nthem\tO\nwere\tO\nlater\tO\nexcluded\tO\nbecause\tO\nof\tO\nadverse\tO\neffects\tO\nof\tO\nPTU\tB-Chemical\nor\tO\nbecause\tO\nthe\tO\nobservation\tO\nperiod\tO\nwas\tO\nless\tO\nthan\tO\n3\tO\nmonths\tO\n.\tO\n\nThe\tO\nremaining\tO\n73\tO\npatients\tO\n(\tO\n55\tO\nwomen\tO\nand\tO\n18\tO\nmen\tO\n)\tO\n,\tO\nall\tO\nof\tO\nwhom\tO\nwere\tO\nexamined\tO\nfor\tO\nmore\tO\nthan\tO\n3\tO\nmonths\tO\n,\tO\nwere\tO\nadopted\tO\nas\tO\nthe\tO\nsubjects\tO\nof\tO\nthe\tO\ninvestigation\tO\n.\tO\n\nThe\tO\nmedian\tO\nobservation\tO\nperiod\tO\nwas\tO\n23\tO\n.\tO\n6\tO\nmonths\tO\n(\tO\nrange\tO\n:\tO\n3\tO\n-\tO\n37\tO\nmonths\tO\n)\tO\n.\tO\n\nMEASUREMENTS\tO\n:\tO\nMPO\tO\n-\tO\nANCA\tO\nwas\tO\nmeasured\tO\nat\tO\nintervals\tO\nof\tO\n2\tO\n-\tO\n6\tO\nmonths\tO\n.\tO\n\nRESULTS\tO\n:\tO\nBefore\tO\ntreatment\tO\n,\tO\nthe\tO\nMPO\tO\n-\tO\nANCA\tO\ntitres\tO\nof\tO\nall\tO\n102\tO\nuntreated\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\npatients\tO\nwere\tO\nwithin\tO\nthe\tO\nreference\tO\nrange\tO\n(\tO\nbelow\tO\n10\tO\nU\tO\n/\tO\nml\tO\n)\tO\n.\tO\n\nThree\tO\n(\tO\n4\tO\n.\tO\n1\tO\n%\tO\n)\tO\nof\tO\nthe\tO\n73\tO\npatients\tO\nwere\tO\npositive\tO\nfor\tO\nMPO\tO\n-\tO\nANCA\tO\nat\tO\n13\tO\n,\tO\n16\tO\nand\tO\n17\tO\nmonths\tO\n,\tO\nrespectively\tO\n,\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\nPTU\tB-Chemical\ntherapy\tO\n.\tO\n\nIn\tO\ntwo\tO\nof\tO\nthem\tO\n,\tO\nthe\tO\nMPO\tO\n-\tO\nANCA\tO\ntitres\tO\ntransiently\tO\nincreased\tO\nto\tO\n12\tO\n.\tO\n8\tO\nand\tO\n15\tO\n.\tO\n0\tO\nU\tO\n/\tO\nml\tO\n,\tO\nrespectively\tO\n,\tO\ndespite\tO\ncontinued\tO\nPTU\tB-Chemical\ntherapy\tO\n,\tO\nbut\tO\nno\tO\nvasculitic\tB-Disease\ndisorders\tI-Disease\ndeveloped\tO\n.\tO\n\nIn\tO\nthe\tO\nthird\tO\npatient\tO\n,\tO\nthe\tO\nMPO\tO\n-\tO\nANCA\tO\ntitre\tO\nincreased\tO\nto\tO\n204\tO\nU\tO\n/\tO\nml\tO\nand\tO\nshe\tO\ndeveloped\tO\na\tO\nhigher\tO\nfever\tB-Disease\n,\tO\noral\tB-Disease\nulcers\tI-Disease\nand\tO\npolyarthralgia\tB-Disease\n,\tO\nbut\tO\nthe\tO\nsymptoms\tO\nresolved\tO\n2\tO\nweeks\tO\nafter\tO\nstopping\tO\nPTU\tB-Chemical\ntherapy\tO\n,\tO\nand\tO\nthe\tO\nMPO\tO\n-\tO\nANCA\tO\ntitre\tO\ndecreased\tO\nto\tO\n20\tO\n.\tO\n7\tO\nU\tO\n/\tO\nml\tO\nby\tO\n4\tO\nmonths\tO\nafter\tO\ndiscontinuing\tO\nPTU\tB-Chemical\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPTU\tB-Chemical\ntherapy\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nthe\tO\nappearance\tO\nof\tO\nMPO\tO\n-\tO\nANCA\tO\n,\tO\nbut\tO\nMPO\tO\n-\tO\nANCA\tO\ndoes\tO\nnot\tO\nappear\tO\nto\tO\nbe\tO\nclosely\tO\nrelated\tO\nto\tO\nvasculitis\tB-Disease\n.\tO\n\nPrevalence\tO\nof\tO\nheart\tB-Disease\ndisease\tI-Disease\nin\tO\nasymptomatic\tO\nchronic\tO\ncocaine\tB-Chemical\nusers\tO\n.\tO\n\nTo\tO\ndetermine\tO\nthe\tO\nprevalence\tO\nof\tO\nheart\tB-Disease\ndisease\tI-Disease\nin\tO\noutpatient\tO\nyoung\tO\nasymptomatic\tO\nchronic\tO\ncocaine\tB-Chemical\nusers\tO\n,\tO\n35\tO\ncocaine\tB-Chemical\nusers\tO\nand\tO\n32\tO\nage\tO\n-\tO\nmatched\tO\ncontrols\tO\nunderwent\tO\nresting\tO\nand\tO\nexercise\tO\nelectrocardiography\tO\n(\tO\nECG\tO\n)\tO\nand\tO\nDoppler\tO\nechocardiography\tO\n.\tO\n\nFindings\tO\nconsistent\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nwere\tO\ndetected\tO\nin\tO\n12\tO\n(\tO\n34\tO\n%\tO\n)\tO\npatients\tO\nand\tO\n3\tO\n(\tO\n9\tO\n%\tO\n)\tO\ncontrols\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nDecreased\tO\nleft\tO\nventricular\tO\nsystolic\tO\nfunction\tO\nwas\tO\ndemonstrated\tO\nin\tO\n5\tO\n(\tO\n14\tO\n%\tO\n)\tO\npatients\tO\n,\tO\nbut\tO\nin\tO\nnone\tO\nof\tO\nthe\tO\ncontrols\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n055\tO\n)\tO\n.\tO\n\nFinally\tO\n,\tO\nresting\tO\nand\tO\npeak\tO\nexercise\tO\nabnormal\tB-Disease\nleft\tI-Disease\nventricular\tI-Disease\nfilling\tI-Disease\nwas\tO\ndetected\tO\nin\tO\n38\tO\nand\tO\n35\tO\n%\tO\nof\tO\npatients\tO\nas\tO\ncompared\tO\nto\tO\n19\tO\nand\tO\n9\tO\n%\tO\nof\tO\ncontrols\tO\n,\tO\nrespectively\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n11\tO\nand\tO\n0\tO\n.\tO\n02\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\ncoronary\tB-Disease\nartery\tI-Disease\nor\tI-Disease\nmyocardial\tI-Disease\ndisease\tI-Disease\nis\tO\ncommon\tO\n(\tO\n38\tO\n%\tO\n)\tO\nin\tO\nyoung\tO\nasymptomatic\tO\nchronic\tO\ncocaine\tB-Chemical\nusers\tO\n.\tO\n\nTherefore\tO\n,\tO\nscreening\tO\nECG\tO\nand\tO\nechocardiography\tO\nmay\tO\nbe\tO\nwarranted\tO\nin\tO\nthese\tO\npatients\tO\n.\tO\n\nCardioprotective\tO\neffects\tO\nof\tO\nPicrorrhiza\tO\nkurroa\tO\nagainst\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tO\nstress\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\ncardioprotective\tO\neffect\tO\nof\tO\nthe\tO\nethanol\tB-Chemical\nextract\tO\nof\tO\nPicrorrhiza\tO\nkurroa\tO\nrhizomes\tO\nand\tO\nroots\tO\n(\tO\nPK\tO\n)\tO\non\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\nwith\tO\nrespect\tO\nto\tO\nlipid\tO\nmetabolism\tO\nin\tO\nserum\tO\nand\tO\nheart\tO\ntissue\tO\nhas\tO\nbeen\tO\ninvestigated\tO\n.\tO\n\nOral\tO\npre\tO\n-\tO\ntreatment\tO\nwith\tO\nPK\tO\n(\tO\n80\tO\nmg\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\nday\tO\n(\tO\n-\tO\n1\tO\n)\tO\nfor\tO\n15\tO\ndays\tO\n)\tO\nsignificantly\tO\nprevented\tO\nthe\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nand\tO\nmaintained\tO\nthe\tO\nrats\tO\nat\tO\nnear\tO\nnormal\tO\nstatus\tO\n.\tO\n\nPhase\tO\n2\tO\nearly\tO\nafterdepolarization\tO\nas\tO\na\tO\ntrigger\tO\nof\tO\npolymorphic\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nin\tO\nacquired\tO\nlong\tB-Disease\n-\tI-Disease\nQT\tI-Disease\nsyndrome\tI-Disease\n:\tO\ndirect\tO\nevidence\tO\nfrom\tO\nintracellular\tO\nrecordings\tO\nin\tO\nthe\tO\nintact\tO\nleft\tO\nventricular\tO\nwall\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThis\tO\nstudy\tO\nexamined\tO\nthe\tO\nrole\tO\nof\tO\nphase\tO\n2\tO\nearly\tO\nafterdepolarization\tO\n(\tO\nEAD\tO\n)\tO\nin\tO\nproducing\tO\na\tO\ntrigger\tO\nto\tO\ninitiate\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\nTdP\tB-Disease\n)\tO\nwith\tO\nQT\tB-Disease\nprolongation\tI-Disease\ninduced\tO\nby\tO\ndl\tO\n-\tO\nsotalol\tB-Chemical\nand\tO\nazimilide\tB-Chemical\n.\tO\n\nThe\tO\ncontribution\tO\nof\tO\ntransmural\tO\ndispersion\tO\nof\tO\nrepolarization\tO\n(\tO\nTDR\tO\n)\tO\nto\tO\ntransmural\tO\npropagation\tO\nof\tO\nEAD\tO\nand\tO\nthe\tO\nmaintenance\tO\nof\tO\nTdP\tB-Disease\nwas\tO\nalso\tO\nevaluated\tO\n.\tO\n\nMETHODS\tO\nAND\tO\nRESULTS\tO\n:\tO\nTransmembrane\tO\naction\tO\npotentials\tO\nfrom\tO\nepicardium\tO\n,\tO\nmidmyocardium\tO\n,\tO\nand\tO\nendocardium\tO\nwere\tO\nrecorded\tO\nsimultaneously\tO\n,\tO\ntogether\tO\nwith\tO\na\tO\ntransmural\tO\nECG\tO\n,\tO\nin\tO\narterially\tO\nperfused\tO\ncanine\tO\nand\tO\nrabbit\tO\nleft\tO\nventricular\tO\npreparations\tO\n.\tO\n\ndl\tO\n-\tO\nSotalol\tB-Chemical\npreferentially\tO\nprolonged\tO\naction\tO\npotential\tO\nduration\tO\n(\tO\nAPD\tO\n)\tO\nin\tO\nM\tO\ncells\tO\ndose\tO\n-\tO\ndependently\tO\n(\tO\n1\tO\nto\tO\n100\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\n,\tO\nleading\tO\nto\tO\nQT\tB-Disease\nprolongation\tI-Disease\nand\tO\nan\tO\nincrease\tO\nin\tO\nTDR\tO\n.\tO\n\nAzimilide\tB-Chemical\n,\tO\nhowever\tO\n,\tO\nsignificantly\tO\nprolonged\tO\nAPD\tO\nand\tO\nQT\tO\ninterval\tO\nat\tO\nconcentrations\tO\nfrom\tO\n0\tO\n.\tO\n1\tO\nto\tO\n10\tO\nmicromol\tO\n/\tO\nL\tO\nbut\tO\nshortened\tO\nthem\tO\nat\tO\n30\tO\nmicromol\tO\n/\tO\nL\tO\n.\tO\n\nUnlike\tO\ndl\tO\n-\tO\nsotalol\tB-Chemical\n,\tO\nazimilide\tB-Chemical\n(\tO\n>\tO\n3\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nincreased\tO\nepicardial\tO\nAPD\tO\nmarkedly\tO\n,\tO\ncausing\tO\na\tO\ndiminished\tO\nTDR\tO\n.\tO\n\nAlthough\tO\nboth\tO\ndl\tO\n-\tO\nsotalol\tB-Chemical\nand\tO\nazimilide\tB-Chemical\nrarely\tO\ninduced\tO\nEADs\tO\nin\tO\ncanine\tO\nleft\tO\nventricles\tO\n,\tO\nthey\tO\nproduced\tO\nfrequent\tO\nEADs\tO\nin\tO\nrabbits\tO\n,\tO\nin\tO\nwhich\tO\nmore\tO\npronounced\tO\nQT\tB-Disease\nprolongation\tI-Disease\nwas\tO\nseen\tO\n.\tO\n\nAn\tO\nincrease\tO\nin\tO\nTDR\tO\nby\tO\ndl\tO\n-\tO\nsotalol\tB-Chemical\nfacilitated\tO\ntransmural\tO\npropagation\tO\nof\tO\nEADs\tO\nthat\tO\ninitiated\tO\nmultiple\tO\nepisodes\tO\nof\tO\nspontaneous\tO\nTdP\tB-Disease\nin\tO\n3\tO\nof\tO\n6\tO\nrabbit\tO\nleft\tO\nventricles\tO\n.\tO\n\nOf\tO\nnote\tO\n,\tO\nalthough\tO\nazimilide\tB-Chemical\n(\tO\n3\tO\nto\tO\n10\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nincreased\tO\nAPD\tO\nmore\tO\nthan\tO\ndl\tO\n-\tO\nsotalol\tB-Chemical\n,\tO\nits\tO\nEADs\tO\noften\tO\nfailed\tO\nto\tO\npropagate\tO\ntransmurally\tO\n,\tO\nprobably\tO\nbecause\tO\nof\tO\na\tO\ndiminished\tO\nTDR\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThis\tO\nstudy\tO\nprovides\tO\nthe\tO\nfirst\tO\ndirect\tO\nevidence\tO\nfrom\tO\nintracellular\tO\naction\tO\npotential\tO\nrecordings\tO\nthat\tO\nphase\tO\n2\tO\nEAD\tO\ncan\tO\nbe\tO\ngenerated\tO\nfrom\tO\nintact\tO\nventricular\tO\nwall\tO\nand\tO\nproduce\tO\na\tO\ntrigger\tO\nto\tO\ninitiate\tO\nthe\tO\nonset\tO\nof\tO\nTdP\tB-Disease\nunder\tO\nQT\tB-Disease\nprolongation\tI-Disease\n.\tO\n\nA\tO\npilot\tO\nstudy\tO\nto\tO\nassess\tO\nthe\tO\nsafety\tO\nof\tO\ndobutamine\tB-Chemical\nstress\tO\nechocardiography\tO\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nevaluation\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nChest\tB-Disease\npain\tI-Disease\nin\tO\nthe\tO\nsetting\tO\nof\tO\ncocaine\tB-Chemical\nuse\tO\nposes\tO\na\tO\ndiagnostic\tO\ndilemma\tO\n.\tO\n\nDobutamine\tB-Chemical\nstress\tO\nechocardiography\tO\n(\tO\nDSE\tO\n)\tO\nis\tO\na\tO\nwidely\tO\navailable\tO\nand\tO\nsensitive\tO\ntest\tO\nfor\tO\nevaluating\tO\ncardiac\tO\nischemia\tB-Disease\n.\tO\n\nBecause\tO\nof\tO\nthe\tO\ntheoretical\tO\nconcern\tO\nregarding\tO\nadministration\tO\nof\tO\ndobutamine\tB-Chemical\nin\tO\nthe\tO\nsetting\tO\nof\tO\ncocaine\tB-Chemical\nuse\tO\n,\tO\nwe\tO\nconducted\tO\na\tO\npilot\tO\nstudy\tO\nto\tO\nassess\tO\nthe\tO\nsafety\tO\nof\tO\nDSE\tO\nin\tO\nemergency\tO\ndepartment\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nprospective\tO\ncase\tO\nseries\tO\nwas\tO\nconducted\tO\nin\tO\nthe\tO\nintensive\tO\ndiagnostic\tO\nand\tO\ntreatment\tO\nunit\tO\nin\tO\nthe\tO\nED\tO\nof\tO\nan\tO\nurban\tO\ntertiary\tO\n-\tO\ncare\tO\nteaching\tO\nhospital\tO\n.\tO\n\nPatients\tO\nwere\tO\neligible\tO\nfor\tO\nDSE\tO\nif\tO\nthey\tO\nhad\tO\nused\tO\ncocaine\tB-Chemical\nwithin\tO\n24\tO\nhours\tO\npreceding\tO\nthe\tO\nonset\tO\nof\tO\nchest\tB-Disease\npain\tI-Disease\nand\tO\nhad\tO\na\tO\nnormal\tO\nECG\tO\nand\tO\ntropinin\tO\nI\tO\nlevel\tO\n.\tO\n\nPatients\tO\nexhibiting\tO\nsigns\tO\nof\tO\ncontinuing\tO\ncocaine\tB-Chemical\ntoxicity\tB-Disease\nwere\tO\nexcluded\tO\nfrom\tO\nthe\tO\nstudy\tO\n.\tO\n\nAll\tO\npatients\tO\nwere\tO\nadmitted\tO\nto\tO\nthe\tO\nhospital\tO\nfor\tO\nserial\tO\ntesting\tO\nafter\tO\nthe\tO\nDSE\tO\ntesting\tO\nin\tO\nthe\tO\nintensive\tO\ndiagnostic\tO\nand\tO\ntreatment\tO\nunit\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTwenty\tO\n-\tO\nfour\tO\npatients\tO\nwere\tO\nenrolled\tO\n.\tO\n\nTwo\tO\npatients\tO\nhad\tO\ninadequate\tO\nresting\tO\nimages\tO\n,\tO\none\tO\nDSE\tO\nwas\tO\nterminated\tO\nbecause\tO\nof\tO\ninferior\tO\nhypokinesis\tB-Disease\n,\tO\nanother\tO\nDSE\tO\nwas\tO\nterminated\tO\nbecause\tO\nof\tO\na\tO\nrate\tO\n-\tO\nrelated\tO\natrial\tO\nconduction\tO\ndeficit\tO\n,\tO\nand\tO\n1\tO\npatient\tO\ndid\tO\nnot\tO\nreach\tO\nthe\tO\ntarget\tO\nheart\tO\nrate\tO\n.\tO\n\nThus\tO\n,\tO\n19\tO\npatients\tO\ncompleted\tO\na\tO\nDSE\tO\nand\tO\nreached\tO\ntheir\tO\ntarget\tO\nheart\tO\nrates\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\npatients\tO\nexperienced\tO\nsigns\tO\nof\tO\nexaggerated\tO\nadrenergic\tO\nresponse\tO\n,\tO\nwhich\tO\nwas\tO\ndefined\tO\nas\tO\na\tO\nsystolic\tO\nblood\tO\npressure\tO\nof\tO\ngreater\tO\nthan\tO\n200\tO\nmm\tO\nHg\tO\nor\tO\nthe\tO\noccurrence\tO\nof\tO\ntachydysrhythmias\tB-Disease\n(\tO\nexcluding\tO\nsinus\tB-Disease\ntachycardia\tI-Disease\n)\tO\n.\tO\n\nFurther\tO\nsuggesting\tO\nlack\tO\nof\tO\nexaggerated\tO\nadrenergic\tO\nresponse\tO\n,\tO\n13\tO\n(\tO\n65\tO\n%\tO\n)\tO\nof\tO\n20\tO\npatients\tO\nrequired\tO\nsupplemental\tO\natropine\tB-Chemical\nto\tO\nreach\tO\ntheir\tO\ntarget\tO\nheart\tO\nrates\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nNo\tO\nexaggerated\tO\nadrenergic\tO\nresponse\tO\nwas\tO\ndetected\tO\nwhen\tO\ndobutamine\tB-Chemical\nwas\tO\nadministered\tO\nto\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nrelated\tO\nchest\tB-Disease\npain\tI-Disease\n.\tO\n\nPrenatal\tO\ncocaine\tB-Chemical\nexposure\tO\nand\tO\ncranial\tO\nsonographic\tO\nfindings\tO\nin\tO\npreterm\tB-Disease\ninfants\tI-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nPrenatal\tO\ncocaine\tB-Chemical\nexposure\tO\nhas\tO\nbeen\tO\nlinked\tO\nwith\tO\nsubependymal\tO\nhemorrhage\tB-Disease\nand\tO\nthe\tO\nformation\tO\nof\tO\ncysts\tB-Disease\nthat\tO\nare\tO\ndetectable\tO\non\tO\ncranial\tO\nsonography\tO\nin\tO\nneonates\tO\nborn\tO\nat\tO\nterm\tO\n.\tO\n\nWe\tO\nsought\tO\nto\tO\ndetermine\tO\nif\tO\nprenatal\tO\ncocaine\tB-Chemical\nexposure\tO\nincreases\tO\nthe\tO\nincidence\tO\nof\tO\nsubependymal\tB-Disease\ncysts\tI-Disease\nin\tO\npreterm\tB-Disease\ninfants\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nretrospectively\tO\nreviewed\tO\nthe\tO\nmedical\tO\nrecords\tO\nand\tO\ncranial\tO\nsonograms\tO\nobtained\tO\nduring\tO\na\tO\n1\tO\n-\tO\nyear\tO\nperiod\tO\non\tO\n122\tO\npremature\tB-Disease\n(\tI-Disease\n<\tI-Disease\n36\tI-Disease\nweeks\tI-Disease\nof\tI-Disease\ngestation\tI-Disease\n)\tI-Disease\ninfants\tI-Disease\n.\tO\n\nInfants\tO\nwere\tO\ncategorized\tO\ninto\tO\n1\tO\nof\tO\n2\tO\ngroups\tO\n:\tO\nthose\tO\nexposed\tO\nto\tO\ncocaine\tB-Chemical\nand\tO\nthose\tO\nnot\tO\nexposed\tO\nto\tO\ncocaine\tB-Chemical\n.\tO\n\nInfants\tO\nwere\tO\nassigned\tO\nto\tO\nthe\tO\ncocaine\tB-Chemical\n-\tO\nexposed\tO\ngroup\tO\nif\tO\nthere\tO\nwas\tO\na\tO\nmaternal\tO\nhistory\tO\nof\tO\ncocaine\tB-Disease\nabuse\tI-Disease\nduring\tO\npregnancy\tO\nor\tO\nif\tO\nmaternal\tO\nor\tO\nneonatal\tO\nurine\tO\ntoxicology\tO\nresults\tO\nwere\tO\npositive\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\ndelivery\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFive\tO\nof\tO\nthe\tO\n122\tO\ninfants\tO\nwere\tO\nexcluded\tO\nfrom\tO\nthe\tO\nstudy\tO\nbecause\tO\nof\tO\ninsufficient\tO\nmedical\tO\nand\tO\ndrug\tO\nhistories\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nsubependymal\tB-Disease\ncysts\tI-Disease\nin\tO\nthe\tO\n117\tO\nremaining\tO\ninfants\tO\nwas\tO\n14\tO\n%\tO\n(\tO\n16\tO\nof\tO\n117\tO\n)\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nsubependymal\tB-Disease\ncysts\tI-Disease\nin\tO\ninfants\tO\nexposed\tO\nto\tO\ncocaine\tB-Chemical\nprenatally\tO\nwas\tO\n44\tO\n%\tO\n(\tO\n8\tO\nof\tO\n18\tO\n)\tO\ncompared\tO\nwith\tO\n8\tO\n%\tO\n(\tO\n8\tO\nof\tO\n99\tO\n)\tO\nin\tO\nthe\tO\nunexposed\tO\ngroup\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nfound\tO\nan\tO\nincreased\tO\nincidence\tO\nof\tO\nsubependymal\tB-Disease\ncyst\tI-Disease\nformation\tO\nin\tO\npreterm\tB-Disease\ninfants\tI-Disease\nwho\tO\nwere\tO\nexposed\tO\nto\tO\ncocaine\tB-Chemical\nprenatally\tO\n.\tO\n\nThis\tO\nresult\tO\nis\tO\nconsistent\tO\nwith\tO\nresults\tO\nof\tO\nsimilar\tO\nstudies\tO\nin\tO\nterm\tO\ninfants\tO\n.\tO\n\nThalidomide\tB-Chemical\nneuropathy\tB-Disease\nin\tO\npatients\tO\ntreated\tO\nfor\tO\nmetastatic\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nWe\tO\nprospectively\tO\nevaluated\tO\nthalidomide\tB-Chemical\n-\tO\ninduced\tO\nneuropathy\tB-Disease\nusing\tO\nelectrodiagnostic\tO\nstudies\tO\n.\tO\n\nSixty\tO\n-\tO\nseven\tO\nmen\tO\nwith\tO\nmetastatic\tO\nandrogen\tB-Chemical\n-\tO\nindependent\tO\nprostate\tB-Disease\ncancer\tI-Disease\nin\tO\nan\tO\nopen\tO\n-\tO\nlabel\tO\ntrial\tO\nof\tO\noral\tO\nthalidomide\tB-Chemical\nunderwent\tO\nneurologic\tO\nexaminations\tO\nand\tO\nnerve\tO\nconduction\tO\nstudies\tO\n(\tO\nNCS\tO\n)\tO\nprior\tO\nto\tO\nand\tO\nat\tO\n3\tO\n-\tO\nmonth\tO\nintervals\tO\nduring\tO\ntreatment\tO\n.\tO\n\nNCS\tO\nincluded\tO\nrecording\tO\nof\tO\nsensory\tO\nnerve\tO\naction\tO\npotentials\tO\n(\tO\nSNAPs\tO\n)\tO\nfrom\tO\nmedian\tO\n,\tO\nradial\tO\n,\tO\nulnar\tO\n,\tO\nand\tO\nsural\tO\nnerves\tO\n.\tO\n\nSNAP\tO\namplitudes\tO\nfor\tO\neach\tO\nnerve\tO\nwere\tO\nexpressed\tO\nas\tO\nthe\tO\npercentage\tO\nof\tO\nits\tO\nbaseline\tO\n,\tO\nand\tO\nthe\tO\nmean\tO\nof\tO\nthe\tO\nfour\tO\nwas\tO\ntermed\tO\nthe\tO\nSNAP\tO\nindex\tO\n.\tO\n\nA\tO\n40\tO\n%\tO\ndecline\tO\nin\tO\nthe\tO\nSNAP\tO\nindex\tO\nwas\tO\nconsidered\tO\nclinically\tO\nsignificant\tO\n.\tO\n\nThalidomide\tB-Chemical\nwas\tO\ndiscontinued\tO\nin\tO\n55\tO\npatients\tO\nfor\tO\nlack\tO\nof\tO\ntherapeutic\tO\nresponse\tO\n.\tO\n\nOf\tO\n67\tO\npatients\tO\ninitially\tO\nenrolled\tO\n,\tO\n24\tO\nremained\tO\non\tO\nthalidomide\tB-Chemical\nfor\tO\n3\tO\nmonths\tO\n,\tO\n8\tO\nremained\tO\nat\tO\n6\tO\nmonths\tO\n,\tO\nand\tO\n3\tO\nremained\tO\nat\tO\n9\tO\nmonths\tO\n.\tO\n\nSix\tO\npatients\tO\ndeveloped\tO\nneuropathy\tB-Disease\n.\tO\n\nClinical\tO\nsymptoms\tO\nand\tO\na\tO\ndecline\tO\nin\tO\nthe\tO\nSNAP\tO\nindex\tO\noccurred\tO\nconcurrently\tO\n.\tO\n\nOlder\tO\nage\tO\nand\tO\ncumulative\tO\ndose\tO\nwere\tO\npossible\tO\ncontributing\tO\nfactors\tO\n.\tO\n\nNeuropathy\tB-Disease\nmay\tO\nthus\tO\nbe\tO\na\tO\ncommon\tO\ncomplication\tO\nof\tO\nthalidomide\tB-Chemical\nin\tO\nolder\tO\npatients\tO\n.\tO\n\nThe\tO\nSNAP\tO\nindex\tO\ncan\tO\nbe\tO\nused\tO\nto\tO\nmonitor\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\n,\tO\nbut\tO\nnot\tO\nfor\tO\nearly\tO\ndetection\tO\n.\tO\n\nOverexpression\tO\nof\tO\ncopper\tB-Chemical\n/\tO\nzinc\tB-Chemical\n-\tO\nsuperoxide\tB-Chemical\ndismutase\tO\nprotects\tO\nfrom\tO\nkanamycin\tB-Chemical\n-\tO\ninduced\tO\nhearing\tB-Disease\nloss\tI-Disease\n.\tO\n\nThe\tO\nparticipation\tO\nof\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\nin\tO\naminoglycoside\tB-Chemical\n-\tO\ninduced\tO\nototoxicity\tB-Disease\nhas\tO\nbeen\tO\ndeduced\tO\nfrom\tO\nobservations\tO\nthat\tO\naminoglycoside\tB-Chemical\n-\tO\niron\tB-Chemical\ncomplexes\tO\ncatalyze\tO\nthe\tO\nformation\tO\nof\tO\nsuperoxide\tB-Chemical\nradicals\tO\nin\tO\nvitro\tO\nand\tO\nthat\tO\nantioxidants\tO\nattenuate\tO\nototoxicity\tB-Disease\nin\tO\nvivo\tO\n.\tO\n\nWe\tO\ntherefore\tO\nhypothesized\tO\nthat\tO\noverexpression\tO\nof\tO\nCu\tB-Chemical\n/\tO\nZn\tB-Chemical\n-\tO\nsuperoxide\tB-Chemical\ndismutase\tO\n(\tO\nh\tO\n-\tO\nSOD1\tO\n)\tO\nshould\tO\nprotect\tO\ntransgenic\tO\nmice\tO\nfrom\tO\nototoxicity\tB-Disease\n.\tO\n\nImmunocytochemistry\tO\nconfirmed\tO\nexpression\tO\nof\tO\nh\tO\n-\tO\nSOD1\tO\nin\tO\ninner\tO\near\tO\ntissues\tO\nof\tO\ntransgenic\tO\nC57BL\tO\n/\tO\n6\tO\n-\tO\nTgN\tO\n[\tO\nSOD1\tO\n]\tO\n3Cje\tO\nmice\tO\n.\tO\n\nTransgenic\tO\nand\tO\nnontransgenic\tO\nlittermates\tO\nreceived\tO\nkanamycin\tB-Chemical\n(\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n/\tO\nday\tO\n)\tO\nfor\tO\n10\tO\ndays\tO\nbeginning\tO\non\tO\nday\tO\n10\tO\nafter\tO\nbirth\tO\n.\tO\n\nAuditory\tO\nthresholds\tO\nwere\tO\ntested\tO\nby\tO\nevoked\tO\nauditory\tO\nbrain\tO\nstem\tO\nresponses\tO\nat\tO\n1\tO\nmonth\tO\nafter\tO\nbirth\tO\n.\tO\n\nIn\tO\nnontransgenic\tO\nanimals\tO\n,\tO\nthe\tO\nthreshold\tO\nin\tO\nthe\tO\nkanamycin\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\nwas\tO\n45\tO\n-\tO\n50\tO\ndB\tO\nhigher\tO\nthan\tO\nin\tO\nsaline\tO\n-\tO\ninjected\tO\ncontrols\tO\n.\tO\n\nIn\tO\nthe\tO\ntransgenic\tO\ngroup\tO\n,\tO\nkanamycin\tB-Chemical\nincreased\tO\nthe\tO\nthreshold\tO\nby\tO\nonly\tO\n15\tO\ndB\tO\nover\tO\nthe\tO\nrespective\tO\ncontrols\tO\n.\tO\n\nThe\tO\neffects\tO\nwere\tO\nsimilar\tO\nat\tO\n12\tO\nand\tO\n24\tO\nkHz\tO\n.\tO\n\nThe\tO\nprotection\tO\nby\tO\noverexpression\tO\nof\tO\nsuperoxide\tB-Chemical\ndismutase\tO\nsupports\tO\nthe\tO\nhypothesis\tO\nthat\tO\noxidant\tO\nstress\tO\nplays\tO\na\tO\nsignificant\tO\nrole\tO\nin\tO\naminoglycoside\tB-Chemical\n-\tO\ninduced\tO\nototoxicity\tB-Disease\n.\tO\n\nThe\tO\nresults\tO\nalso\tO\nsuggest\tO\ntransgenic\tO\nanimals\tO\nas\tO\nsuitable\tO\nmodels\tO\nto\tO\ninvestigate\tO\nthe\tO\nunderlying\tO\nmechanisms\tO\nand\tO\npossible\tO\nstrategies\tO\nfor\tO\nprevention\tO\n.\tO\n\nFatty\tB-Disease\nliver\tI-Disease\ninduced\tO\nby\tO\ntetracycline\tB-Chemical\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nDose\tO\n-\tO\nresponse\tO\nrelationships\tO\nand\tO\neffect\tO\nof\tO\nsex\tO\n.\tO\n\nDose\tO\n-\tO\nresponse\tO\nrelationships\tO\n,\tO\nbiochemical\tO\nmechanisms\tO\n,\tO\nand\tO\nsex\tO\ndifferences\tO\nin\tO\nthe\tO\nexperimental\tO\nfatty\tB-Disease\nliver\tI-Disease\ninduced\tO\nby\tO\ntetracycline\tB-Chemical\nwere\tO\nstudied\tO\nin\tO\nthe\tO\nintact\tO\nrat\tO\nand\tO\nwith\tO\nthe\tO\nisolated\tO\nperfused\tO\nrat\tO\nliver\tO\nin\tO\nvitro\tO\n.\tO\n\nIn\tO\nthe\tO\nintact\tO\nmale\tO\nand\tO\nfemale\tO\nrat\tO\n,\tO\nno\tO\ndirect\tO\nrelationship\tO\nwas\tO\nobserved\tO\nbetween\tO\ndose\tO\nof\tO\ntetracycline\tB-Chemical\nand\tO\nhepatic\tO\naccumulation\tO\nof\tO\ntriglyceride\tB-Chemical\n.\tO\n\nWith\tO\nprovision\tO\nof\tO\nadequate\tO\noleic\tB-Chemical\nacid\tI-Chemical\nas\tO\na\tO\nsubstrate\tO\nfor\tO\nthe\tO\nisolated\tO\nperfused\tO\nliver\tO\n,\tO\na\tO\ndirect\tO\nrelationship\tO\nwas\tO\nobserved\tO\nbetween\tO\ndose\tO\nof\tO\ntetracycline\tB-Chemical\nand\tO\nboth\tO\naccumulation\tO\nof\tO\ntriglyceride\tB-Chemical\nin\tO\nthe\tO\nliver\tO\nand\tO\ndepression\tB-Disease\nof\tO\noutput\tO\nof\tO\ntriglyceride\tB-Chemical\nby\tO\nlivers\tO\nfrom\tO\nmale\tO\nand\tO\nfemale\tO\nrats\tO\n.\tO\n\nMarked\tO\ndifferences\tO\nwere\tO\nobserved\tO\nbetween\tO\nfemale\tO\nand\tO\nmale\tO\nrats\tO\nwith\tO\nregard\tO\nto\tO\nbase\tO\nline\tO\n(\tO\ncontrol\tO\n)\tO\nhepatic\tO\nconcentration\tO\nof\tO\ntriglyceride\tB-Chemical\nand\tO\noutput\tO\nof\tO\ntriglyceride\tB-Chemical\n.\tO\n\nAccumulation\tO\nof\tO\nhepatic\tO\ntriglyceride\tB-Chemical\n,\tO\nas\tO\na\tO\nper\tO\ncent\tO\nof\tO\ncontrol\tO\nvalues\tO\n,\tO\nin\tO\nresponse\tO\nto\tO\ngraded\tO\ndoses\tO\nof\tO\ntetracycline\tB-Chemical\n,\tO\ndid\tO\nnot\tO\ndiffer\tO\nsignificantly\tO\nbetween\tO\nmale\tO\n,\tO\nfemale\tO\nand\tO\npregnant\tO\nrat\tO\nlivers\tO\n.\tO\n\nHowever\tO\n,\tO\nlivers\tO\nfrom\tO\nfemale\tO\n,\tO\nand\tO\nespecially\tO\npregnant\tO\nfemale\tO\nrats\tO\n,\tO\nwere\tO\nstrikingly\tO\nresistant\tO\nto\tO\nthe\tO\neffects\tO\nof\tO\ntetracycline\tB-Chemical\non\tO\ndepression\tB-Disease\nof\tO\noutput\tO\nof\tO\ntriglyceride\tB-Chemical\nunder\tO\nthese\tO\nexperimental\tO\nconditions\tO\n.\tO\n\nThese\tO\ndifferences\tO\nbetween\tO\nthe\tO\nsexes\tO\ncould\tO\nnot\tO\nbe\tO\nrelated\tO\nto\tO\naltered\tO\ndisposition\tO\nof\tO\ntetracycline\tB-Chemical\nor\tO\naltered\tO\nuptake\tO\nof\tO\noleic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nDepressed\tO\nhepatic\tO\nsecretion\tO\nof\tO\ntriglyceride\tB-Chemical\naccounted\tO\nonly\tO\nfor\tO\n30\tO\nto\tO\n50\tO\n%\tO\nof\tO\naccumulated\tO\nhepatic\tO\ntriglyceride\tB-Chemical\n,\tO\nindicating\tO\nthat\tO\nadditional\tO\nmechanisms\tO\nmust\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\nproduction\tO\nof\tO\nthe\tO\ntriglyceride\tB-Chemical\n-\tO\nrich\tO\nfatty\tB-Disease\nliver\tI-Disease\nin\tO\nresponse\tO\nto\tO\ntetracycline\tB-Chemical\n.\tO\n\nPrednisone\tB-Chemical\ninduces\tO\nanxiety\tB-Disease\nand\tO\nglial\tO\ncerebral\tO\nchanges\tO\nin\tO\nrats\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nassess\tO\nwhether\tO\nprednisone\tB-Chemical\n(\tO\nPDN\tB-Chemical\n)\tO\nproduces\tO\nanxiety\tB-Disease\nand\tO\n/\tO\nor\tO\ncerebral\tO\nglial\tO\nchanges\tO\nin\tO\nrats\tO\n.\tO\n\nMETHODS\tO\n:\tO\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\nstudied\tO\nand\tO\n3\tO\ngroups\tO\nwere\tO\nformed\tO\n(\tO\n8\tO\nrats\tO\nper\tO\ngroup\tO\n)\tO\n.\tO\n\nThe\tO\nmoderate\tO\n-\tO\ndose\tO\ngroup\tO\nreceived\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nPDN\tB-Chemical\nreleased\tO\nfrom\tO\na\tO\nsubcutaneous\tO\nimplant\tO\n.\tO\n\nIn\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\n,\tO\nimplants\tO\ncontaining\tO\nPDN\tB-Chemical\nequivalent\tO\nto\tO\n60\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nwere\tO\napplied\tO\n.\tO\n\nIn\tO\nthe\tO\ncontrol\tO\ngroup\tO\nimplants\tO\ncontained\tO\nno\tO\nPDN\tB-Chemical\n.\tO\n\nAnxiety\tB-Disease\nwas\tO\nassessed\tO\nusing\tO\nan\tO\nopen\tO\nfield\tO\nand\tO\nelevated\tO\nplus\tO\n-\tO\nmaze\tO\ndevices\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\ncells\tO\nand\tO\ncytoplasmic\tO\ntransformation\tO\nof\tO\nastrocytes\tO\nand\tO\nmicroglia\tO\ncells\tO\nwere\tO\nassessed\tO\nby\tO\nimmunohistochemical\tO\nanalyses\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAnxiety\tB-Disease\nwas\tO\ndocumented\tO\nin\tO\nboth\tO\ngroups\tO\nof\tO\nPDN\tB-Chemical\ntreated\tO\nrats\tO\ncompared\tO\nwith\tO\ncontrols\tO\n.\tO\n\nThe\tO\nmagnitude\tO\nof\tO\ntransformation\tO\nof\tO\nthe\tO\nmicroglia\tO\nassessed\tO\nby\tO\nthe\tO\nnumber\tO\nof\tO\nintersections\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nin\tO\nthe\tO\nPDN\tB-Chemical\ngroups\tO\nthan\tO\nin\tO\ncontrols\tO\nin\tO\nthe\tO\nprefrontal\tO\ncortex\tO\n(\tO\nmoderate\tO\n-\tO\ndose\tO\n,\tO\n24\tO\n.\tO\n1\tO\n;\tO\nhigh\tO\n-\tO\ndose\tO\n,\tO\n23\tO\n.\tO\n6\tO\n;\tO\ncontrols\tO\n18\tO\n.\tO\n7\tO\n;\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nand\tO\nstriatum\tO\n(\tO\nmoderate\tO\n-\tO\ndose\tO\n25\tO\n.\tO\n6\tO\n;\tO\nhigh\tO\n-\tO\ndose\tO\n26\tO\n.\tO\n3\tO\n;\tO\ncontrols\tO\n18\tO\n.\tO\n9\tO\n;\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nbut\tO\nnot\tO\nin\tO\nhippocampus\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\nstained\tO\nmicroglia\tO\ncells\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nin\tO\nthe\tO\nPDN\tB-Chemical\ntreated\tO\ngroups\tO\nin\tO\nthe\tO\nprefrontal\tO\ncortex\tO\nthan\tO\nin\tO\ncontrols\tO\n(\tO\nmoderate\tO\n-\tO\ndose\tO\n,\tO\n29\tO\n.\tO\n1\tO\n;\tO\nhigh\tO\n-\tO\ndose\tO\n,\tO\n28\tO\n.\tO\n4\tO\n;\tO\ncontrol\tO\n,\tO\n17\tO\n.\tO\n7\tO\ncells\tO\nper\tO\nfield\tO\n;\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nStained\tO\nmicroglia\tO\ncells\tO\nwere\tO\nsignificantly\tO\nmore\tO\nnumerous\tO\nstriatum\tO\nand\tO\nhippocampus\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\ncompared\tO\nto\tO\ncontrols\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nSubacute\tO\nexposure\tO\nto\tO\nPDN\tB-Chemical\ninduced\tO\nanxiety\tB-Disease\nand\tO\nreactivity\tO\nof\tO\nmicroglia\tO\n.\tO\n\nThe\tO\nrelevance\tO\nof\tO\nthese\tO\nfeatures\tO\nfor\tO\npatients\tO\nusing\tO\nPDN\tB-Chemical\nremains\tO\nto\tO\nbe\tO\nelucidated\tO\n.\tO\n\nPhase\tO\nII\tO\nstudy\tO\nof\tO\ncarboplatin\tB-Chemical\nand\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nrecurrent\tO\nsquamous\tB-Disease\ncell\tI-Disease\ncarcinoma\tI-Disease\nof\tI-Disease\nthe\tI-Disease\ncervix\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nactivity\tO\nof\tO\nthe\tO\ncombination\tO\nof\tO\ncarboplatin\tB-Chemical\nand\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\nwas\tO\ntested\tO\nin\tO\na\tO\nPhase\tO\nII\tO\nstudy\tO\nof\tO\npatients\tO\nwith\tO\nrecurrent\tO\ncervical\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\ncombination\tO\nof\tO\ncarboplatin\tB-Chemical\n(\tO\narea\tO\nunder\tO\nthe\tO\nconcentration\tO\ncurve\tO\n[\tO\nAUC\tO\n]\tO\n,\tO\n5\tO\n)\tO\nand\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\n(\tO\nDoxil\tB-Chemical\n;\tO\nstarting\tO\ndose\tO\n,\tO\n40\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n)\tO\nwas\tO\nadministered\tO\nintravenously\tO\nevery\tO\n28\tO\ndays\tO\nto\tO\n37\tO\npatients\tO\nwith\tO\nrecurrent\tO\nsquamous\tB-Disease\ncell\tI-Disease\ncervical\tI-Disease\ncarcinoma\tI-Disease\nto\tO\ndetermine\tO\nantitumor\tO\nactivity\tO\nand\tO\ntoxicity\tB-Disease\nprofile\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTwenty\tO\n-\tO\nnine\tO\npatients\tO\nwere\tO\nassessable\tO\nfor\tO\nresponse\tO\n,\tO\nand\tO\n35\tO\npatients\tO\nwere\tO\nassessable\tO\nfor\tO\ntoxicity\tB-Disease\n.\tO\n\nThe\tO\noverall\tO\nresponse\tO\nrate\tO\nwas\tO\n38\tO\n%\tO\n,\tO\nthe\tO\nmedian\tO\ntime\tO\nto\tO\nresponse\tO\nwas\tO\n10\tO\nweeks\tO\n,\tO\nthe\tO\nmedian\tO\nduration\tO\nof\tO\nresponse\tO\nwas\tO\n26\tO\nweeks\tO\n,\tO\nand\tO\nthe\tO\nmedian\tO\nsurvival\tO\nwas\tO\n37\tO\nweeks\tO\n.\tO\n\nThe\tO\nmain\tO\ntoxic\tO\neffect\tO\nwas\tO\nmyelosuppression\tB-Disease\n,\tO\nwith\tO\nGrade\tO\n3\tO\nand\tO\n4\tO\nneutropenia\tB-Disease\nin\tO\n16\tO\npatients\tO\n,\tO\nanemia\tB-Disease\nin\tO\n12\tO\npatients\tO\n,\tO\nthrombocytopenia\tB-Disease\nin\tO\n11\tO\npatients\tO\n,\tO\nand\tO\nneutropenic\tB-Disease\nfever\tI-Disease\nin\tO\n3\tO\npatients\tO\n.\tO\n\nFour\tO\npatients\tO\nhad\tO\nfive\tO\ninfusion\tO\n-\tO\nrelated\tO\nreactions\tO\nduring\tO\nthe\tO\ninfusion\tO\nof\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\n,\tO\nleading\tO\nto\tO\ntreatment\tO\ndiscontinuation\tO\nin\tO\nthree\tO\npatients\tO\n.\tO\n\nGrade\tO\n>\tO\nor\tO\n=\tO\n2\tO\nnonhematologic\tO\ntoxicity\tB-Disease\nincluded\tO\nnausea\tB-Disease\nin\tO\n17\tO\npatients\tO\n,\tO\nemesis\tB-Disease\nin\tO\n14\tO\npatients\tO\n,\tO\nfatigue\tB-Disease\nin\tO\n9\tO\npatients\tO\n,\tO\nmucositis\tB-Disease\nand\tO\n/\tO\nor\tO\nstomatitis\tB-Disease\nin\tO\n8\tO\npatients\tO\n,\tO\nconstipation\tB-Disease\nin\tO\n6\tO\npatients\tO\n,\tO\nweight\tB-Disease\nloss\tI-Disease\nin\tO\n5\tO\npatients\tO\n,\tO\nhand\tB-Disease\n-\tI-Disease\nfoot\tI-Disease\nsyndrome\tI-Disease\nin\tO\n2\tO\npatients\tO\n,\tO\nand\tO\nskin\tB-Disease\nreactions\tI-Disease\nin\tO\n3\tO\npatients\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tO\nof\tO\ncarboplatin\tB-Chemical\nand\tO\nliposomal\tO\ndoxorubicin\tB-Chemical\nhas\tO\nmodest\tO\nactivity\tO\nin\tO\npatients\tO\nwith\tO\nrecurrent\tO\ncervical\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nAntimicrobial\tO\n-\tO\ninduced\tO\nmania\tB-Disease\n(\tO\nantibiomania\tB-Disease\n)\tO\n:\tO\na\tO\nreview\tO\nof\tO\nspontaneous\tO\nreports\tO\n.\tO\n\nThe\tO\nauthors\tO\nreviewed\tO\nreported\tO\ncases\tO\nof\tO\nantibiotic\tO\n-\tO\ninduced\tO\nmanic\tB-Disease\nepisodes\tO\nby\tO\nmeans\tO\nof\tO\na\tO\nMEDLINE\tO\nand\tO\nPsychLit\tO\nsearch\tO\nfor\tO\nreports\tO\nof\tO\nantibiotic\tO\n-\tO\ninduced\tO\nmania\tB-Disease\n.\tO\n\nUnpublished\tO\nreports\tO\nwere\tO\nrequested\tO\nfrom\tO\nthe\tO\nWorld\tO\nHealth\tO\nOrganization\tO\n(\tO\nWHO\tO\n)\tO\nand\tO\nthe\tO\nFood\tO\nand\tO\nDrug\tO\nAdministration\tO\n(\tO\nFDA\tO\n)\tO\n.\tO\n\nTwenty\tO\n-\tO\none\tO\nreports\tO\nof\tO\nantimicrobial\tO\n-\tO\ninduced\tO\nmania\tB-Disease\nwere\tO\nfound\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nThere\tO\nwere\tO\n6\tO\ncases\tO\nimplicating\tO\nclarithromycin\tB-Chemical\n,\tO\n13\tO\nimplicating\tO\nisoniazid\tB-Chemical\n,\tO\nand\tO\n1\tO\ncase\tO\neach\tO\nimplicating\tO\nerythromycin\tB-Chemical\nand\tO\namoxicillin\tB-Chemical\n.\tO\n\nThe\tO\nWHO\tO\nreported\tO\n82\tO\ncases\tO\n.\tO\n\nOf\tO\nthese\tO\n,\tO\nclarithromycin\tB-Chemical\nwas\tO\nimplicated\tO\nin\tO\n23\tO\n(\tO\n27\tO\n.\tO\n6\tO\n%\tO\n)\tO\ncases\tO\n,\tO\nciprofloxacin\tB-Chemical\nin\tO\n12\tO\n(\tO\n14\tO\n.\tO\n4\tO\n%\tO\n)\tO\ncases\tO\n,\tO\nand\tO\nofloxacin\tB-Chemical\nin\tO\n10\tO\n(\tO\n12\tO\n%\tO\n)\tO\ncases\tO\n.\tO\n\nCotrimoxazole\tB-Chemical\n,\tO\nmetronidazole\tB-Chemical\n,\tO\nand\tO\nerythromycin\tB-Chemical\nwere\tO\ninvolved\tO\nin\tO\n15\tO\nreported\tO\nmanic\tB-Disease\nepisodes\tO\n.\tO\n\nCases\tO\nreported\tO\nby\tO\nthe\tO\nFDA\tO\nshowed\tO\nclarithromycin\tB-Chemical\nand\tO\nciprofloxacin\tB-Chemical\nto\tO\nbe\tO\nthe\tO\nmost\tO\nfrequently\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nmania\tB-Disease\n.\tO\n\nStatistical\tO\nanalysis\tO\nof\tO\nthe\tO\ndata\tO\nwould\tO\nnot\tO\nhave\tO\ndemonstrated\tO\na\tO\nsignificant\tO\nstatistical\tO\ncorrelative\tO\nrisk\tO\nand\tO\nwas\tO\ntherefore\tO\nnot\tO\nundertaken\tO\n.\tO\n\nPatients\tO\nhave\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\ndeveloping\tO\nmania\tB-Disease\nwhile\tO\nbeing\tO\ntreated\tO\nwith\tO\nantimicrobials\tO\n.\tO\n\nAlthough\tO\nthis\tO\nis\tO\nnot\tO\na\tO\nstatistically\tO\nsignificant\tO\nrisk\tO\n,\tO\nphysicians\tO\nmust\tO\nbe\tO\naware\tO\nof\tO\nthe\tO\neffect\tO\nand\tO\nreversibility\tO\n.\tO\n\nFurther\tO\nresearch\tO\nclearly\tO\nis\tO\nrequired\tO\nto\tO\ndetermine\tO\nthe\tO\nincidence\tO\nof\tO\nantimicrobial\tO\n-\tO\ninduced\tO\nmania\tB-Disease\n,\tO\nthe\tO\nrelative\tO\nrisk\tO\nfactors\tO\nof\tO\ndeveloping\tO\nan\tO\nantimicrobial\tO\n-\tO\ninduced\tO\nmanic\tB-Disease\nepisode\tO\namong\tO\nvarious\tO\ndemographic\tO\npopulations\tO\n,\tO\nand\tO\nthe\tO\nincidence\tO\nof\tO\npatients\tO\nwho\tO\ncontinue\tO\nto\tO\nhave\tO\npersistent\tO\naffective\tO\ndisorders\tO\nonce\tO\nthe\tO\ninitial\tO\nepisode\tO\n,\tO\nwhich\tO\noccurs\tO\nwhile\tO\nthe\tO\npatient\tO\nis\tO\ntaking\tO\nantibiotics\tO\n,\tO\nsubsides\tO\n.\tO\n\nThe\tO\nauthors\tO\nelected\tO\nto\tO\nname\tO\nthis\tO\nsyndrome\tO\n\"\tO\nantibiomania\tB-Disease\n.\tO\n\"\tO\n\nLevodopa\tB-Chemical\n-\tO\ninduced\tO\nocular\tB-Disease\ndyskinesias\tI-Disease\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nLevodopa\tB-Chemical\n-\tO\ninduced\tO\nocular\tB-Disease\ndyskinesias\tI-Disease\nare\tO\nvery\tO\nuncommon\tO\n.\tO\n\nUsually\tO\nthey\tO\noccur\tO\nsimultaneously\tO\nwith\tO\nlimb\tO\npeak\tO\n-\tO\ndose\tO\nchoreatic\tB-Disease\ndyskinesias\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\non\tO\na\tO\npatient\tO\nwith\tO\nleftward\tO\nand\tO\nupward\tO\ndeviations\tO\nof\tO\ngaze\tO\nduring\tO\nthe\tO\npeak\tO\neffect\tO\nof\tO\nlevodopa\tB-Chemical\n,\tO\nand\tO\nhypothesize\tO\nthat\tO\na\tO\nsevere\tO\ndopaminergic\tO\ndenervation\tO\nin\tO\nthe\tO\ncaudate\tO\nnucleus\tO\nis\tO\nneeded\tO\nfor\tO\nthe\tO\nappearance\tO\nof\tO\nthese\tO\nlevodopa\tB-Chemical\n-\tO\ninduce\tO\nocular\tB-Disease\ndyskinesias\tI-Disease\n.\tO\n\nA\tO\ncomparison\tO\nof\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\nwith\tO\ndiclofenac\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nprimary\tO\ndysmenorrhea\tB-Disease\n:\tO\nan\tO\nopen\tO\n,\tO\nrandomized\tO\n,\tO\ncross\tO\n-\tO\nover\tO\ntrial\tO\n.\tO\n\nPrimary\tO\ndysmenorrhea\tB-Disease\nis\tO\na\tO\nsyndrome\tO\ncharacterized\tO\nby\tO\npainful\tO\nuterine\tO\ncontractility\tO\ncaused\tO\nby\tO\na\tO\nhypersecretion\tO\nof\tO\nendometrial\tO\nprostaglandins\tB-Chemical\n;\tO\nnon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\nare\tO\nthe\tO\nfirst\tO\nchoice\tO\nfor\tO\nits\tO\ntreatment\tO\n.\tO\n\nHowever\tO\n,\tO\nin\tO\nvivo\tO\nand\tO\nin\tO\nvitro\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nthat\tO\nmyometrial\tO\ncells\tO\nare\tO\nalso\tO\ntargets\tO\nof\tO\nthe\tO\nrelaxant\tO\neffects\tO\nof\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\nefficacy\tO\nof\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\n(\tO\nGTN\tB-Chemical\n)\tO\n,\tO\nan\tO\nNO\tB-Chemical\ndonor\tO\n,\tO\nin\tO\nthe\tO\nresolution\tO\nof\tO\nprimary\tO\ndysmenorrhea\tB-Disease\nin\tO\ncomparison\tO\nwith\tO\ndiclofenac\tB-Chemical\n(\tO\nDCF\tB-Chemical\n)\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n24\tO\npatients\tO\nwith\tO\nthe\tO\ndiagnosis\tO\nof\tO\nsevere\tO\nprimary\tO\ndysmenorrhea\tB-Disease\nwere\tO\nstudied\tO\nduring\tO\ntwo\tO\nconsecutive\tO\nmenstrual\tO\ncycles\tO\n.\tO\n\nIn\tO\nan\tO\nopen\tO\n,\tO\ncross\tO\n-\tO\nover\tO\n,\tO\ncontrolled\tO\ndesign\tO\n,\tO\npatients\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\neither\tO\nDCF\tB-Chemical\nper\tO\nos\tO\nor\tO\nGTN\tB-Chemical\npatches\tO\nthe\tO\nfirst\tO\ndays\tO\nof\tO\nmenses\tO\n,\tO\nwhen\tO\nmenstrual\tO\ncramps\tO\nbecame\tO\nunendurable\tO\n.\tO\n\nIn\tO\nthe\tO\nsubsequent\tO\ncycle\tO\nthe\tO\nother\tO\ntreatment\tO\nwas\tO\nused\tO\n.\tO\n\nPatients\tO\nreceived\tO\nup\tO\nto\tO\n3\tO\ndoses\tO\n/\tO\nday\tO\nof\tO\n50\tO\nmg\tO\nDCF\tB-Chemical\nor\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\n24\tO\nh\tO\ntransdermal\tO\nGTN\tB-Chemical\nfor\tO\nthe\tO\nfirst\tO\n3\tO\ndays\tO\nof\tO\nthe\tO\ncycle\tO\n,\tO\naccording\tO\nto\tO\ntheir\tO\nneeds\tO\n.\tO\n\nThe\tO\nparticipants\tO\nrecorded\tO\nmenstrual\tO\nsymptoms\tO\nand\tO\npossible\tO\nside\tO\n-\tO\neffects\tO\nat\tO\ndifferent\tO\ntimes\tO\n(\tO\n0\tO\n,\tO\n30\tO\n,\tO\n60\tO\n,\tO\n120\tO\nminutes\tO\n)\tO\nafter\tO\nthe\tO\nfirst\tO\ndose\tO\nof\tO\nmedication\tO\non\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\nthe\tO\ncycle\tO\n,\tO\nwith\tO\nboth\tO\ndrugs\tO\n.\tO\n\nThe\tO\ndifference\tO\nin\tO\npain\tB-Disease\nintensity\tO\nscore\tO\n(\tO\nDPI\tO\n)\tO\nwas\tO\nthe\tO\nmain\tO\noutcome\tO\nvariable\tO\n.\tO\n\nBoth\tO\ntreatments\tO\nsignificantly\tO\nreduced\tO\nDPI\tO\nby\tO\nthe\tO\n30th\tO\nminute\tO\n(\tO\nGTN\tB-Chemical\n,\tO\n-\tO\n12\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n17\tO\n.\tO\n9\tO\n;\tO\nDCF\tB-Chemical\n,\tO\n-\tO\n18\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n16\tO\n.\tO\n6\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nDCF\tB-Chemical\ncontinued\tO\nto\tO\nbe\tO\neffective\tO\nin\tO\nreducing\tO\npelvic\tB-Disease\npain\tI-Disease\nfor\tO\ntwo\tO\nhours\tO\n,\tO\nwhereas\tO\nGTN\tB-Chemical\nscores\tO\nremained\tO\nmore\tO\nor\tO\nless\tO\nstable\tO\nafter\tO\n30\tO\nmin\tO\nand\tO\nsignificantly\tO\nhigher\tO\nthan\tO\nthose\tO\nfor\tO\nDFC\tO\n(\tO\nafter\tO\none\tO\nhour\tO\n:\tO\nGTN\tB-Chemical\n,\tO\n-\tO\n12\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n17\tO\n.\tO\n9\tO\n;\tO\nDFC\tO\n,\tO\n-\tO\n18\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n16\tO\n.\tO\n6\tO\nand\tO\nafter\tO\ntwo\tO\nhours\tO\n:\tO\nGTN\tB-Chemical\n,\tO\n-\tO\n23\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n20\tO\n.\tO\n5\tO\n;\tO\nDFC\tO\n,\tO\n-\tO\n59\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n17\tO\n.\tO\n9\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nLow\tB-Disease\nback\tI-Disease\npain\tI-Disease\nwas\tO\nalso\tO\nrelieved\tO\nby\tO\nboth\tO\ndrugs\tO\n.\tO\n\nHeadache\tB-Disease\nwas\tO\nsignificantly\tO\nincreased\tO\nby\tO\nGTN\tB-Chemical\nbut\tO\nnot\tO\nby\tO\nDCF\tB-Chemical\n.\tO\n\nEight\tO\npatients\tO\nstopped\tO\nusing\tO\nGTN\tB-Chemical\nbecause\tO\nheadache\tB-Disease\n-\tO\n-\tO\nattributed\tO\nto\tO\nits\tO\nuse\tO\n-\tO\n-\tO\nbecame\tO\nintolerable\tO\n.\tO\n\nThese\tO\nfindings\tO\nindicate\tO\nthat\tO\nGTN\tB-Chemical\nhas\tO\na\tO\nreduced\tO\nefficacy\tO\nand\tO\ntolerability\tO\nby\tO\ncomparison\tO\nwith\tO\nDCF\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nprimary\tO\ndysmenorrhea\tB-Disease\n.\tO\n\nTemocapril\tB-Chemical\n,\tO\na\tO\nlong\tO\n-\tO\nacting\tO\nnon\tO\n-\tO\nSH\tO\ngroup\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitor\tO\n,\tO\nmodulates\tO\nglomerular\tB-Disease\ninjury\tI-Disease\nin\tO\nchronic\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nnephrosis\tB-Disease\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nwhether\tO\nchronic\tO\nadministration\tO\nof\tO\ntemocapril\tB-Chemical\n,\tO\na\tO\nlong\tO\n-\tO\nacting\tO\nnon\tO\n-\tO\nSH\tO\ngroup\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\n(\tO\nACE\tO\n)\tO\ninhibitor\tO\n,\tO\nreduced\tO\nproteinuria\tB-Disease\n,\tO\ninhibited\tO\nglomerular\tO\nhypertrophy\tB-Disease\nand\tO\nprevented\tO\nglomerulosclerosis\tB-Disease\nin\tO\nchronic\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nrats\tO\n.\tO\n\nNephrosis\tB-Disease\nwas\tO\ninduced\tO\nby\tO\ninjection\tO\nof\tO\nPAN\tB-Chemical\n(\tO\n15mg\tO\n/\tO\n100g\tO\nbody\tO\nweight\tO\n)\tO\nin\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\n(\tO\nSD\tO\n)\tO\nrats\tO\n.\tO\n\nFour\tO\ngroups\tO\nwere\tO\nused\tO\n,\tO\ni\tO\n)\tO\nthe\tO\nPAN\tB-Chemical\ngroup\tO\n(\tO\n14\tO\n)\tO\n,\tO\nii\tO\n)\tO\nPAN\tB-Chemical\n/\tO\ntemocapril\tB-Chemical\n(\tO\n13\tO\n)\tO\n,\tO\niii\tO\n)\tO\ntemocapril\tB-Chemical\n(\tO\n14\tO\n)\tO\nand\tO\niv\tO\n)\tO\nuntreated\tO\ncontrols\tO\n(\tO\n15\tO\n)\tO\n.\tO\n\nTemocapril\tB-Chemical\n(\tO\n8\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n)\tO\nwas\tO\nadministered\tO\nto\tO\nthe\tO\nrats\tO\nwhich\tO\nwere\tO\nkilled\tO\nat\tO\nweeks\tO\n4\tO\n,\tO\n14\tO\nor\tO\n20\tO\n.\tO\n\nAt\tO\neach\tO\ntime\tO\npoint\tO\n,\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\n,\tO\nurinary\tO\nprotein\tO\nexcretion\tO\nand\tO\nrenal\tO\nhistopathological\tO\nfindings\tO\nwere\tO\nevaluated\tO\n,\tO\nand\tO\nmorphometric\tO\nimage\tO\nanalysis\tO\nwas\tO\ndone\tO\n.\tO\n\nSystolic\tO\nBP\tO\nin\tO\nthe\tO\nPAN\tB-Chemical\ngroup\tO\nwas\tO\nsignificantly\tO\nhigh\tO\nat\tO\n4\tO\n,\tO\n14\tO\nand\tO\n20\tO\nweeks\tO\n,\tO\nbut\tO\nwas\tO\nnormal\tO\nin\tO\nthe\tO\nPAN\tB-Chemical\n/\tO\ntemocapril\tB-Chemical\ngroup\tO\n.\tO\n\nUrinary\tO\nprotein\tO\nexcretion\tO\nin\tO\nthe\tO\nPAN\tB-Chemical\ngroup\tO\nincreased\tO\nsignificantly\tO\n,\tO\npeaking\tO\nat\tO\n8\tO\ndays\tO\n,\tO\nthen\tO\ndecreased\tO\nat\tO\n4\tO\nweeks\tO\n,\tO\nbut\tO\nrose\tO\nagain\tO\nsignificantly\tO\nat\tO\n14\tO\nand\tO\n20\tO\nweeks\tO\n.\tO\n\nTemocapril\tB-Chemical\ndid\tO\nnot\tO\nattenuate\tO\nproteinuria\tB-Disease\nat\tO\n8\tO\ndays\tO\n,\tO\nbut\tO\nit\tO\ndid\tO\nmarkedly\tO\nlower\tO\nit\tO\nfrom\tO\nweeks\tO\n4\tO\nto\tO\n20\tO\n.\tO\n\nThe\tO\nglomerulosclerosis\tB-Disease\nindex\tO\n(\tO\nGSI\tO\n)\tO\nwas\tO\n6\tO\n.\tO\n21\tO\n%\tO\nat\tO\n4\tO\nweeks\tO\nand\tO\nrespectively\tO\n25\tO\n.\tO\n35\tO\n%\tO\nand\tO\n30\tO\n.\tO\n49\tO\n%\tO\nat\tO\n14\tO\nand\tO\n20\tO\nweeks\tO\nin\tO\nthe\tO\nPAN\tB-Chemical\ngroup\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\ncorrelation\tO\nbetween\tO\nurinary\tO\nprotein\tO\nexcretion\tO\nand\tO\nGSI\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n808\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nThe\tO\nratio\tO\nof\tO\nglomerular\tO\ntuft\tO\narea\tO\nto\tO\nthe\tO\narea\tO\nof\tO\nBowman\tO\n'\tO\ns\tO\ncapsules\tO\n(\tO\nGT\tO\n/\tO\nBC\tO\n)\tO\nin\tO\nthe\tO\nPAN\tB-Chemical\ngroup\tO\nwas\tO\nsignificantly\tO\nincreased\tO\n,\tO\nbut\tO\nit\tO\nwas\tO\nsignificantly\tO\nlower\tO\nin\tO\nthe\tO\nPAN\tB-Chemical\n/\tO\ntemocapril\tB-Chemical\ngroup\tO\n.\tO\n\nIt\tO\nappears\tO\nthat\tO\ntemocapril\tB-Chemical\nwas\tO\neffective\tO\nin\tO\nretarding\tO\nrenal\tO\nprogression\tO\nand\tO\nprotected\tO\nrenal\tO\nfunction\tO\nin\tO\nPAN\tB-Chemical\nneprotic\tB-Disease\nrats\tO\n.\tO\n\nPulmonary\tB-Disease\nhypertension\tI-Disease\nafter\tO\nibuprofen\tB-Chemical\nprophylaxis\tO\nin\tO\nvery\tO\npreterm\tO\ninfants\tO\n.\tO\n\nWe\tO\nreport\tO\nthree\tO\ncases\tO\nof\tO\nsevere\tO\nhypoxaemia\tB-Disease\nafter\tO\nibuprofen\tB-Chemical\nadministration\tO\nduring\tO\na\tO\nrandomised\tO\ncontrolled\tO\ntrial\tO\nof\tO\nprophylactic\tO\ntreatment\tO\nof\tO\npatent\tB-Disease\nductus\tI-Disease\narteriosus\tI-Disease\nwith\tO\nibuprofen\tB-Chemical\nin\tO\npremature\tO\ninfants\tO\nborn\tO\nat\tO\nless\tO\nthan\tO\n28\tO\nweeks\tO\nof\tO\ngestation\tO\n.\tO\n\nEchocardiography\tO\nshowed\tO\nseverely\tO\ndecreased\tO\npulmonary\tO\nblood\tO\nflow\tO\n.\tO\n\nHypoxaemia\tB-Disease\nresolved\tO\nquickly\tO\non\tO\ninhaled\tO\nnitric\tB-Chemical\noxide\tI-Chemical\ntherapy\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\ninvestigators\tO\ninvolved\tO\nin\tO\nsimilar\tO\ntrials\tO\npay\tO\nclose\tO\nattention\tO\nto\tO\npulmonary\tO\npressure\tO\nif\tO\nhypoxaemia\tB-Disease\noccurs\tO\nafter\tO\nprophylactic\tO\nadministration\tO\nof\tO\nibuprofen\tB-Chemical\n.\tO\n\nHyponatremia\tB-Disease\nand\tO\nsyndrome\tB-Disease\nof\tI-Disease\ninappropriate\tI-Disease\nanti\tI-Disease\n-\tI-Disease\ndiuretic\tI-Disease\nhormone\tI-Disease\nreported\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nVincristine\tB-Chemical\n:\tO\nan\tO\nover\tO\n-\tO\nrepresentation\tO\nof\tO\nAsians\tO\n?\tO\n\nPURPOSE\tO\n:\tO\nThis\tO\nretrospective\tO\nstudy\tO\nused\tO\na\tO\npharmaceutical\tO\ncompany\tO\n'\tO\ns\tO\nglobal\tO\nsafety\tO\ndatabase\tO\nto\tO\ndetermine\tO\nthe\tO\nreporting\tO\nrate\tO\nof\tO\nhyponatremia\tB-Disease\nand\tO\n/\tO\nor\tO\nsyndrome\tB-Disease\nof\tI-Disease\ninappropriate\tI-Disease\nsecretion\tI-Disease\nof\tI-Disease\nanti\tI-Disease\n-\tI-Disease\ndiuretic\tI-Disease\nhormone\tI-Disease\n(\tO\nSIADH\tB-Disease\n)\tO\namong\tO\nvincristine\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nand\tO\nto\tO\nexplore\tO\nthe\tO\npossibility\tO\nof\tO\nat\tO\n-\tO\nrisk\tO\npopulation\tO\nsubgroups\tO\n.\tO\n\nMETHOD\tO\n:\tO\nWe\tO\nsearched\tO\nthe\tO\nEli\tO\nLilly\tO\nand\tO\nCompany\tO\n'\tO\ns\tO\ncomputerized\tO\nadverse\tO\nevent\tO\ndatabase\tO\nfor\tO\nall\tO\nreported\tO\ncases\tO\nof\tO\nhyponatremia\tB-Disease\nand\tO\n/\tO\nor\tO\nSIADH\tB-Disease\nas\tO\nof\tO\n1\tO\nNovember\tO\n1999\tO\nthat\tO\nhad\tO\nbeen\tO\nreported\tO\nduring\tO\nthe\tO\nuse\tO\nof\tO\nvincristine\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n76\tO\ncases\tO\nof\tO\nhyponatremia\tB-Disease\nand\tO\n/\tO\nor\tO\nSIADH\tB-Disease\nassociated\tO\nwith\tO\nvincristine\tB-Chemical\nuse\tO\nwere\tO\nidentified\tO\n.\tO\n\nThe\tO\noverall\tO\nreporting\tO\nrate\tO\nwas\tO\nestimated\tO\nto\tO\nbe\tO\n1\tO\n.\tO\n3\tO\n/\tO\n100\tO\n,\tO\n000\tO\ntreated\tO\npatients\tO\n.\tO\n\nThe\tO\naverage\tO\nage\tO\nof\tO\npatients\tO\nwas\tO\n35\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n28\tO\n.\tO\n3\tO\nyears\tO\n,\tO\nand\tO\n62\tO\n%\tO\nwere\tO\nmales\tO\n.\tO\n\nApproximately\tO\n75\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\nwere\tO\nreceiving\tO\ntreatment\tO\nfor\tO\nleukemia\tB-Disease\nor\tO\nlymphoma\tB-Disease\n.\tO\n\nAmong\tO\nthe\tO\n39\tO\nreports\tO\nthat\tO\nincluded\tO\ninformation\tO\non\tO\nrace\tO\n,\tO\nthe\tO\nracial\tO\ndistribution\tO\nwas\tO\n:\tO\n1\tO\nBlack\tO\n,\tO\n3\tO\nCaucasian\tO\n,\tO\nand\tO\n35\tO\nAsian\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\ndata\tO\nsuggest\tO\nthat\tO\nAsian\tO\npatients\tO\nmay\tO\nbe\tO\nat\tO\nincreased\tO\nrisk\tO\nof\tO\nhyponatremia\tB-Disease\nand\tO\n/\tO\nor\tO\nSIADH\tB-Disease\nassociated\tO\nwith\tO\nvincristine\tB-Chemical\nuse\tO\n.\tO\n\nAlthough\tO\nthe\tO\noverall\tO\nreported\tO\nrate\tO\nof\tO\nSIADH\tB-Disease\nassociated\tO\nwith\tO\nvincristine\tB-Chemical\nis\tO\nvery\tO\nlow\tO\n,\tO\nphysicians\tO\ncaring\tO\nfor\tO\nAsian\tO\noncology\tO\npatients\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\npotential\tO\nserious\tO\nbut\tO\nreversible\tO\nadverse\tO\nevent\tO\n.\tO\n\nDelayed\tO\ntoxicity\tB-Disease\nof\tO\ncyclophosphamide\tB-Chemical\non\tO\nthe\tO\nbladder\tO\nof\tO\nDBA\tO\n/\tO\n2\tO\nand\tO\nC57BL\tO\n/\tO\n6\tO\nfemale\tO\nmouse\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\ndescribes\tO\nthe\tO\ndelayed\tO\ndevelopment\tO\nof\tO\na\tO\nsevere\tO\nbladder\tO\npathology\tO\nin\tO\na\tO\nsusceptible\tO\nstrain\tO\nof\tO\nmice\tO\n(\tO\nDBA\tO\n/\tO\n2\tO\n)\tO\nbut\tO\nnot\tO\nin\tO\na\tO\nresistant\tO\nstrain\tO\n(\tO\nC57BL\tO\n/\tO\n6\tO\n)\tO\nwhen\tO\nboth\tO\nwere\tO\ntreated\tO\nwith\tO\na\tO\nsingle\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\ndose\tO\nof\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCY\tB-Chemical\n)\tO\n.\tO\n\nInbred\tO\nDBA\tO\n/\tO\n2\tO\nand\tO\nC57BL\tO\n/\tO\n6\tO\nfemale\tO\nmice\tO\nwere\tO\ninjected\tO\nwith\tO\nCY\tB-Chemical\n,\tO\nand\tO\nthe\tO\neffect\tO\nof\tO\nthe\tO\ndrug\tO\non\tO\nthe\tO\nbladder\tO\nwas\tO\nassessed\tO\nduring\tO\n100\tO\ndays\tO\nby\tO\nlight\tO\nmicroscopy\tO\nusing\tO\ndifferent\tO\nstaining\tO\nprocedures\tO\n,\tO\nand\tO\nafter\tO\n30\tO\ndays\tO\nby\tO\nconventional\tO\nelectron\tO\nmicroscopy\tO\n.\tO\n\nEarly\tO\nCY\tB-Chemical\ntoxicity\tB-Disease\ncaused\tO\na\tO\ntypical\tO\nhaemorrhagic\tB-Disease\ncystitis\tB-Disease\nin\tO\nboth\tO\nstrains\tO\nthat\tO\nwas\tO\ncompletely\tO\nrepaired\tO\nin\tO\nabout\tO\n7\tO\n-\tO\n10\tO\ndays\tO\n.\tO\n\nAfter\tO\n30\tO\ndays\tO\nof\tO\nCY\tB-Chemical\ninjection\tO\nulcerous\tO\nand\tO\nnon\tO\n-\tO\nulcerous\tO\nforms\tO\nof\tO\nchronic\tO\ncystitis\tB-Disease\nappeared\tO\nin\tO\n86\tO\n%\tO\nof\tO\nDBA\tO\n/\tO\n2\tO\nmice\tO\nbut\tO\nonly\tO\nin\tO\n4\tO\n%\tO\nof\tO\nC57BL\tO\n/\tO\n6\tO\nmice\tO\n.\tO\n\nDelayed\tO\ncystitis\tB-Disease\nwas\tO\ncharacterized\tO\nby\tO\ninfiltration\tO\nand\tO\ntransepithelial\tO\npassage\tO\ninto\tO\nthe\tO\nlumen\tO\nof\tO\ninflammatory\tO\ncells\tO\nand\tO\nby\tO\nfrequent\tO\nexfoliation\tO\nof\tO\nthe\tO\nurothelium\tO\n.\tO\n\nMast\tO\ncells\tO\nappeared\tO\nin\tO\nthe\tO\nconnective\tO\nand\tO\nmuscular\tO\nlayers\tO\nof\tO\nthe\tO\nbladder\tO\nat\tO\na\tO\nmuch\tO\nhigher\tO\nnumber\tO\nin\tO\nDBA\tO\n/\tO\n2\tO\nmice\tO\nthan\tO\nin\tO\nC57BL\tO\n/\tO\n6\tO\nmice\tO\nor\tO\nuntreated\tO\ncontrols\tO\n.\tO\n\nElectron\tO\nmicroscopy\tO\ndisclosed\tO\nthe\tO\nabsence\tO\nof\tO\nthe\tO\ntypical\tO\ndiscoidal\tO\nvesicles\tO\nnormally\tO\npresent\tO\nin\tO\nthe\tO\ncytoplasm\tO\nof\tO\nsurface\tO\ncells\tO\n.\tO\n\nInstead\tO\n,\tO\nnumerous\tO\nabnormal\tO\nvesicles\tO\ncontaining\tO\none\tO\nor\tO\nseveral\tO\ndark\tO\ngranules\tO\nwere\tO\nobserved\tO\nin\tO\nthe\tO\ncytoplasm\tO\nof\tO\ncells\tO\nfrom\tO\nall\tO\nthe\tO\nepithelial\tO\nlayers\tO\n.\tO\n\nDelayed\tO\ncystitis\tB-Disease\nstill\tO\npersisted\tO\nin\tO\nDBA\tO\n/\tO\n2\tO\nmice\tO\n100\tO\ndays\tO\nafter\tO\ntreatment\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\ndelayed\tO\ntoxicity\tB-Disease\nof\tO\nCY\tB-Chemical\nin\tO\nfemale\tO\nDBA\tO\n/\tO\n2\tO\nmice\tO\ncauses\tO\na\tO\nbladder\tO\npathology\tO\nthat\tO\nis\tO\nnot\tO\nobserved\tO\nin\tO\nC57BL\tO\n/\tO\n6\tO\nmice\tO\n.\tO\n\nThis\tO\npathology\tO\nresembles\tO\ninterstitial\tB-Disease\ncystitis\tI-Disease\nin\tO\nhumans\tO\nand\tO\ncould\tO\nperhaps\tO\nbe\tO\nused\tO\nas\tO\nan\tO\nanimal\tO\nmodel\tO\nfor\tO\nstudies\tO\non\tO\nthe\tO\ndisease\tO\n.\tO\n\nHigh\tO\n-\tO\ndose\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n/\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\nin\tO\ncombination\tO\nwith\tO\nthree\tO\n-\tO\nweekly\tO\nmitomycin\tB-Chemical\nC\tI-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nadvanced\tO\ngastric\tB-Disease\ncancer\tI-Disease\n.\tO\n\nA\tO\nphase\tO\nII\tO\nstudy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\n24\tO\n-\tO\nhour\tO\ncontinuous\tO\ninfusion\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\nand\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\n(\tO\nFA\tB-Chemical\n)\tO\nas\tO\npart\tO\nof\tO\nseveral\tO\nnew\tO\nmultidrug\tO\nchemotherapy\tO\nregimens\tO\nin\tO\nadvanced\tO\ngastric\tB-Disease\ncancer\tI-Disease\n(\tO\nAGC\tB-Disease\n)\tO\nhas\tO\nshown\tO\nto\tO\nbe\tO\neffective\tO\n,\tO\nwith\tO\nlow\tO\ntoxicity\tB-Disease\n.\tO\n\nIn\tO\na\tO\nprevious\tO\nphase\tO\nII\tO\nstudy\tO\nwith\tO\n3\tO\n-\tO\nweekly\tO\nbolus\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n,\tO\nFA\tB-Chemical\nand\tO\nmitomycin\tB-Chemical\nC\tI-Chemical\n(\tO\nMMC\tB-Chemical\n)\tO\nwe\tO\nfound\tO\na\tO\nlow\tO\ntoxicity\tB-Disease\nrate\tO\nand\tO\nresponse\tO\nrates\tO\ncomparable\tO\nto\tO\nthose\tO\nof\tO\nregimens\tO\nsuch\tO\nas\tO\nELF\tO\n,\tO\nFAM\tO\nor\tO\nFAMTX\tO\n,\tO\nand\tO\na\tO\npromising\tO\nmedian\tO\noverall\tO\nsurvival\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\nimprove\tO\nthis\tO\nMMC\tB-Chemical\n-\tO\ndependent\tO\nschedule\tO\nwe\tO\ninitiated\tO\na\tO\nphase\tO\nII\tO\nstudy\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n/\tO\nFA\tB-Chemical\nand\tO\n3\tO\n-\tO\nweekly\tO\nbolus\tO\nMMC\tB-Chemical\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nFrom\tO\nFebruary\tO\n,\tO\n1998\tO\nto\tO\nSeptember\tO\n,\tO\n2000\tO\nwe\tO\nrecruited\tO\n33\tO\npatients\tO\nwith\tO\nAGC\tB-Disease\nto\tO\nreceive\tO\nweekly\tO\n24\tO\n-\tO\nhour\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n2\tO\n,\tO\n600\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\npreceded\tO\nby\tO\n2\tO\n-\tO\nhour\tO\nFA\tB-Chemical\n500\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\n6\tO\nweeks\tO\n,\tO\nfollowed\tO\nby\tO\na\tO\n2\tO\n-\tO\nweek\tO\nrest\tO\nperiod\tO\n.\tO\n\nBolus\tO\nMMC\tB-Chemical\n10\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nwas\tO\nadded\tO\nin\tO\n3\tO\n-\tO\nweekly\tO\nintervals\tO\n.\tO\n\nTreatment\tO\ngiven\tO\non\tO\nan\tO\noutpatient\tO\nbasis\tO\n,\tO\nusing\tO\nportable\tO\npump\tO\nsystems\tO\n,\tO\nwas\tO\nrepeated\tO\non\tO\nday\tO\n57\tO\n.\tO\n\nPatients\tO\n'\tO\ncharacteristics\tO\nwere\tO\n:\tO\nmale\tO\n/\tO\nfemale\tO\nratio\tO\n20\tO\n/\tO\n13\tO\n;\tO\nmedian\tO\nage\tO\n57\tO\n(\tO\n27\tO\n-\tO\n75\tO\n)\tO\nyears\tO\n;\tO\nmedian\tO\nWHO\tO\nstatus\tO\n1\tO\n(\tO\n0\tO\n-\tO\n2\tO\n)\tO\n.\tO\n\n18\tO\npatients\tO\nhad\tO\na\tO\nprimary\tO\nAGC\tB-Disease\n,\tO\nand\tO\n15\tO\nshowed\tO\na\tO\nrelapsed\tO\nAGC\tB-Disease\n.\tO\n\nMedian\tO\nfollow\tO\n-\tO\nup\tO\nwas\tO\n11\tO\n.\tO\n8\tO\nmonths\tO\n(\tO\nrange\tO\nof\tO\nthose\tO\nsurviving\tO\n:\tO\n2\tO\n.\tO\n7\tO\n-\tO\n11\tO\n.\tO\n8\tO\nmonths\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\n32\tO\npatients\tO\nwere\tO\nevaluable\tO\nfor\tO\nresponse\tO\n-\tO\ncomplete\tO\nremission\tO\n9\tO\n.\tO\n1\tO\n%\tO\n(\tO\nn\tO\n=\tO\n3\tO\n)\tO\n,\tO\npartial\tO\nremission\tO\n45\tO\n.\tO\n5\tO\n%\tO\n(\tO\nn\tO\n=\tO\n15\tO\n)\tO\n,\tO\nno\tO\nchange\tO\n27\tO\n.\tO\n3\tO\n%\tO\n(\tO\nn\tO\n=\tO\n9\tO\n)\tO\n,\tO\nprogressive\tO\ndisease\tO\n15\tO\n.\tO\n1\tO\n%\tO\n(\tO\nn\tO\n=\tO\n5\tO\n)\tO\n.\tO\n\nMedian\tO\noverall\tO\nsurvival\tO\ntime\tO\nwas\tO\n10\tO\n.\tO\n2\tO\nmonths\tO\n[\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n(\tO\nCI\tO\n)\tO\n:\tO\n8\tO\n.\tO\n7\tO\n-\tO\n11\tO\n.\tO\n6\tO\n]\tO\n,\tO\nand\tO\nmedian\tO\nprogression\tO\n-\tO\nfree\tO\nsurvival\tO\ntime\tO\nwas\tO\n7\tO\n.\tO\n6\tO\nmonths\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n4\tO\n.\tO\n4\tO\n-\tO\n10\tO\n.\tO\n9\tO\n)\tO\n.\tO\n\nThe\tO\nworst\tO\ntoxicities\tB-Disease\n(\tO\n%\tO\n)\tO\nobserved\tO\nwere\tO\n(\tO\nCTC\tO\n-\tO\nNCI\tO\n1\tO\n/\tO\n2\tO\n/\tO\n3\tO\n)\tO\n:\tO\nleukopenia\tB-Disease\n45\tO\n.\tO\n5\tO\n/\tO\n18\tO\n.\tO\n2\tO\n/\tO\n6\tO\n.\tO\n1\tO\n,\tO\nthrombocytopenia\tB-Disease\n33\tO\n.\tO\n3\tO\n/\tO\n9\tO\n.\tO\n1\tO\n/\tO\n6\tO\n.\tO\n1\tO\n,\tO\nvomitus\tB-Disease\n24\tO\n.\tO\n2\tO\n/\tO\n9\tO\n.\tO\n1\tO\n/\tO\n0\tO\n,\tO\ndiarrhea\tB-Disease\n36\tO\n.\tO\n4\tO\n/\tO\n6\tO\n.\tO\n1\tO\n/\tO\n3\tO\n.\tO\n0\tO\n,\tO\nstomatitis\tB-Disease\n18\tO\n.\tO\n2\tO\n/\tO\n9\tO\n.\tO\n1\tO\n/\tO\n0\tO\n,\tO\nhand\tB-Disease\n-\tI-Disease\nfoot\tI-Disease\nsyndrome\tI-Disease\n12\tO\n.\tO\n1\tO\n/\tO\n0\tO\n/\tO\n0\tO\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\nhemolytic\tB-Disease\n-\tI-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\n(\tO\nHUS\tB-Disease\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nHigh\tO\n-\tO\ndose\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n/\tO\nFA\tB-Chemical\n/\tO\nMMC\tB-Chemical\nis\tO\nan\tO\neffective\tO\nand\tO\nwell\tO\n-\tO\ntolerated\tO\noutpatient\tO\nregimen\tO\nfor\tO\nAGC\tB-Disease\n(\tO\nobjective\tO\nresponse\tO\nrate\tO\n54\tO\n.\tO\n6\tO\n%\tO\n)\tO\n.\tO\n\nIt\tO\nmay\tO\nserve\tO\nas\tO\nan\tO\nalternative\tO\nto\tO\ncisplatin\tB-Chemical\n-\tO\ncontaining\tO\nregimens\tO\n;\tO\nhowever\tO\n,\tO\nit\tO\nhas\tO\nto\tO\nbe\tO\nconsidered\tO\nthat\tO\npossibly\tO\nHUS\tB-Disease\nmay\tO\noccur\tO\n.\tO\n\nPersistent\tO\nsterile\tO\nleukocyturia\tB-Disease\nis\tO\nassociated\tO\nwith\tO\nimpaired\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nin\tO\nhuman\tB-Disease\nimmunodeficiency\tI-Disease\nvirus\tI-Disease\ntype\tI-Disease\n1\tI-Disease\n-\tI-Disease\ninfected\tI-Disease\nchildren\tO\ntreated\tO\nwith\tO\nindinavir\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nProlonged\tO\nadministration\tO\nof\tO\nindinavir\tB-Chemical\nis\tO\nassociated\tO\nwith\tO\nthe\tO\noccurrence\tO\nof\tO\na\tO\nvariety\tO\nof\tO\nrenal\tO\ncomplications\tO\nin\tO\nadults\tO\n.\tO\n\nThese\tO\nwell\tO\n-\tO\ndocumented\tO\nside\tO\neffects\tO\nhave\tO\nrestricted\tO\nthe\tO\nuse\tO\nof\tO\nthis\tO\npotent\tO\nprotease\tO\ninhibitor\tO\nin\tO\nchildren\tO\n.\tO\n\nDESIGN\tO\n:\tO\nA\tO\nprospective\tO\nstudy\tO\nto\tO\nmonitor\tO\nindinavir\tB-Chemical\n-\tO\nrelated\tO\nnephrotoxicity\tB-Disease\nin\tO\na\tO\ncohort\tO\nof\tO\n30\tO\nhuman\tB-Disease\nimmunodeficiency\tI-Disease\nvirus\tI-Disease\ntype\tI-Disease\n1\tI-Disease\n-\tI-Disease\ninfected\tI-Disease\nchildren\tO\ntreated\tO\nwith\tO\nindinavir\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nUrinary\tO\npH\tO\n,\tO\nalbumin\tO\n,\tO\ncreatinine\tB-Chemical\n,\tO\nthe\tO\npresence\tO\nof\tO\nerythrocytes\tO\n,\tO\nleukocytes\tO\n,\tO\nbacteria\tO\nand\tO\ncrystals\tO\n,\tO\nand\tO\nculture\tO\nwere\tO\nanalyzed\tO\nevery\tO\n3\tO\nmonths\tO\nfor\tO\n96\tO\nweeks\tO\n.\tO\n\nSerum\tO\ncreatinine\tB-Chemical\nlevels\tO\nwere\tO\nroutinely\tO\ndetermined\tO\nat\tO\nthe\tO\nsame\tO\ntime\tO\npoints\tO\n.\tO\n\nSteady\tO\n-\tO\nstate\tO\npharmacokinetics\tO\nof\tO\nindinavir\tB-Chemical\nwere\tO\ndone\tO\nat\tO\nweek\tO\n4\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\nindinavir\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\ncumulative\tO\nincidence\tO\nof\tO\npersistent\tO\nsterile\tO\nleukocyturia\tB-Disease\n(\tO\n>\tO\nor\tO\n=\tO\n75\tO\ncells\tO\n/\tO\nmicro\tO\nL\tO\nin\tO\nat\tO\nleast\tO\n2\tO\nconsecutive\tO\nvisits\tO\n)\tO\nafter\tO\n96\tO\nweeks\tO\nwas\tO\n53\tO\n%\tO\n.\tO\n\nPersistent\tO\nsterile\tO\nleukocyturia\tB-Disease\nwas\tO\nfrequently\tO\nassociated\tO\nwith\tO\na\tO\nmild\tO\nincrease\tO\nin\tO\nthe\tO\nurine\tO\nalbumin\tO\n/\tO\ncreatinine\tB-Chemical\nratio\tO\nand\tO\nby\tO\nmicroscopic\tO\nhematuria\tB-Disease\n.\tO\n\nThe\tO\ncumulative\tO\nincidence\tO\nof\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\n>\tO\n50\tO\n%\tO\nabove\tO\nnormal\tO\nwas\tO\n33\tO\n%\tO\nafter\tO\n96\tO\nweeks\tO\n.\tO\n\nChildren\tO\nwith\tO\npersistent\tO\nsterile\tO\nleukocyturia\tB-Disease\nmore\tO\nfrequently\tO\nhad\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\nof\tO\n50\tO\n%\tO\nabove\tO\nnormal\tO\nthan\tO\nthose\tO\nchildren\tO\nwithout\tO\npersistent\tO\nsterile\tO\nleukocyturia\tB-Disease\n.\tO\n\nIn\tO\nchildren\tO\nyounger\tO\nthan\tO\n5\tO\n.\tO\n6\tO\nyears\tO\n,\tO\npersistent\tO\nsterile\tO\nleukocyturia\tB-Disease\nwas\tO\nsignificantly\tO\nmore\tO\nfrequent\tO\nthan\tO\nin\tO\nolder\tO\nchildren\tO\n.\tO\n\nA\tO\nhigher\tO\ncumulative\tO\nincidence\tO\nof\tO\npersistent\tO\nleukocyturia\tB-Disease\nwas\tO\nfound\tO\nin\tO\nchildren\tO\nwith\tO\nan\tO\narea\tO\nunder\tO\nthe\tO\ncurve\tO\n>\tO\n19\tO\nmg\tO\n/\tO\nL\tO\nx\tO\nh\tO\nor\tO\na\tO\npeak\tO\nserum\tO\nlevel\tO\nof\tO\nindinavir\tB-Chemical\n>\tO\n12\tO\nmg\tO\n/\tO\nL\tO\n.\tO\n\nIn\tO\n4\tO\nchildren\tO\n,\tO\nindinavir\tB-Chemical\nwas\tO\ndiscontinued\tO\nbecause\tO\nof\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nSubsequently\tO\n,\tO\nthe\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\ndecreased\tO\n,\tO\nthe\tO\nurine\tO\nalbumin\tO\n/\tO\ncreatinine\tB-Chemical\nratios\tO\nreturned\tO\nto\tO\nzero\tO\n,\tO\nand\tO\nthe\tO\nleukocyturia\tB-Disease\ndisappeared\tO\nwithin\tO\n3\tO\nmonths\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nChildren\tO\ntreated\tO\nwith\tO\nindinavir\tB-Chemical\nhave\tO\na\tO\nhigh\tO\ncumulative\tO\nincidence\tO\nof\tO\npersistent\tO\nsterile\tO\nleukocyturia\tB-Disease\n.\tO\n\nChildren\tO\nwith\tO\npersistent\tO\nsterile\tO\nleukocyturia\tB-Disease\nmore\tO\nfrequently\tO\nhad\tO\nan\tO\nincrease\tO\nin\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\nof\tO\n>\tO\n50\tO\n%\tO\nabove\tO\nnormal\tO\n.\tO\n\nYounger\tO\nchildren\tO\nhave\tO\nan\tO\nadditional\tO\nrisk\tO\nfor\tO\nrenal\tO\ncomplications\tO\n.\tO\n\nThe\tO\nimpairment\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nin\tO\nthese\tO\nchildren\tO\noccurred\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nclinical\tO\nsymptoms\tO\nof\tO\nnephrolithiasis\tB-Disease\n.\tO\n\nIndinavir\tB-Chemical\n-\tO\nassociated\tO\nnephrotoxicity\tB-Disease\nmust\tO\nbe\tO\nmonitored\tO\nclosely\tO\n,\tO\nespecially\tO\nin\tO\nchildren\tO\nwith\tO\nrisk\tO\nfactors\tO\nsuch\tO\nas\tO\npersistent\tO\nsterile\tO\nleukocyturia\tB-Disease\n,\tO\nage\tO\n<\tO\n5\tO\n.\tO\n6\tO\nyears\tO\n,\tO\nan\tO\narea\tO\nunder\tO\nthe\tO\ncurve\tO\nof\tO\nindinavir\tB-Chemical\n>\tO\n19\tO\nmg\tO\n/\tO\nL\tO\nx\tO\nh\tO\n,\tO\nand\tO\na\tO\nC\tO\n(\tO\nmax\tO\n)\tO\n>\tO\n12\tO\nmg\tO\n/\tO\nL\tO\n.\tO\n\nUtility\tO\nof\tO\ntroponin\tO\nI\tO\nin\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\n.\tO\n\nBaseline\tO\nelectrocardiogram\tO\nabnormalities\tO\nand\tO\nmarket\tO\nelevations\tO\nnot\tO\nassociated\tO\nwith\tO\nmyocardial\tB-Disease\nnecrosis\tI-Disease\nmake\tO\naccurate\tO\ndiagnosis\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n(\tO\nMI\tB-Disease\n)\tO\ndifficult\tO\nin\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\n.\tO\n\nTroponin\tO\nsampling\tO\nmay\tO\noffer\tO\ngreater\tO\ndiagnostic\tO\nutility\tO\nin\tO\nthese\tO\npatients\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nassess\tO\noutcomes\tO\nbased\tO\non\tO\ntroponin\tO\npositivity\tO\nin\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\nchest\tB-Disease\npain\tI-Disease\nadmitted\tO\nfor\tO\nexclusion\tO\nof\tO\nMI\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nOutcomes\tO\nwere\tO\nexamined\tO\nin\tO\npatients\tO\nadmitted\tO\nfor\tO\npossible\tO\nMI\tB-Disease\nafter\tO\ncocaine\tB-Chemical\nuse\tO\n.\tO\n\nAll\tO\npatients\tO\nunderwent\tO\na\tO\nrapid\tO\nrule\tO\n-\tO\nin\tO\nprotocol\tO\nthat\tO\nincluded\tO\nserial\tO\nsampling\tO\nof\tO\ncreatine\tB-Chemical\nkinase\tO\n(\tO\nCK\tO\n)\tO\n,\tO\nCK\tO\n-\tO\nMB\tO\n,\tO\nand\tO\ncardiac\tO\ntroponin\tO\nI\tO\n(\tO\ncTnI\tO\n)\tO\nover\tO\neight\tO\nhours\tO\n.\tO\n\nOutcomes\tO\nincluded\tO\nCK\tO\n-\tO\nMB\tO\nMI\tB-Disease\n(\tO\nCK\tO\n-\tO\nMB\tO\n>\tO\nor\tO\n=\tO\n8\tO\nng\tO\n/\tO\nmL\tO\nwith\tO\na\tO\nrelative\tO\nindex\tO\n[\tO\n(\tO\nCK\tO\n-\tO\nMB\tO\nx\tO\n100\tO\n)\tO\n/\tO\ntotal\tO\nCK\tO\n]\tO\n>\tO\nor\tO\n=\tO\n4\tO\n,\tO\ncardiac\tB-Disease\ndeath\tI-Disease\n,\tO\nand\tO\nsignificant\tO\ncoronary\tB-Disease\ndisease\tI-Disease\n(\tO\n>\tO\nor\tO\n=\tO\n50\tO\n%\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOf\tO\nthe\tO\n246\tO\nadmitted\tO\npatients\tO\n,\tO\n34\tO\n(\tO\n14\tO\n%\tO\n)\tO\nmet\tO\nCK\tO\n-\tO\nMB\tO\ncriteria\tO\nfor\tO\nMI\tB-Disease\nand\tO\n38\tO\n(\tO\n16\tO\n%\tO\n)\tO\nhad\tO\ncTnI\tO\nelevations\tO\n.\tO\n\nAngiography\tO\nwas\tO\nperformed\tO\nin\tO\n29\tO\nof\tO\n38\tO\npatients\tO\nwho\tO\nwere\tO\ncTnI\tO\n-\tO\npositive\tO\n,\tO\nwith\tO\nsignificant\tO\ndisease\tO\npresent\tO\nin\tO\n25\tO\n(\tO\n86\tO\n%\tO\n)\tO\n.\tO\n\nThree\tO\nof\tO\nthe\tO\nfour\tO\npatients\tO\nwithout\tO\nsignificant\tO\ndisease\tO\nwho\tO\nhad\tO\ncTnI\tO\nelevations\tO\nmet\tO\nCK\tO\n-\tO\nMB\tO\ncriteria\tO\nfor\tO\nMI\tB-Disease\n,\tO\nand\tO\nthe\tO\nother\tO\nhad\tO\na\tO\npeak\tO\nCK\tO\n-\tO\nMB\tO\nlevel\tO\nof\tO\n13\tO\nng\tO\n/\tO\nmL\tO\n.\tO\n\nSensitivities\tO\n,\tO\nspecificities\tO\n,\tO\nand\tO\npositive\tO\nand\tO\nnegative\tO\nlikelihood\tO\nratios\tO\nfor\tO\npredicting\tO\ncardiac\tB-Disease\ndeath\tI-Disease\nor\tO\nsignificant\tO\ndisease\tO\nwere\tO\nhigh\tO\nfor\tO\nboth\tO\nCK\tO\n-\tO\nMB\tO\nMI\tB-Disease\nand\tO\ncTnI\tO\nand\tO\nwere\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nMost\tO\npatients\tO\nwith\tO\ncTnI\tO\nelevations\tO\nmeet\tO\nCK\tO\n-\tO\nMB\tO\ncriteria\tO\nfor\tO\nMI\tB-Disease\n,\tO\nas\tO\nwell\tO\nas\tO\nhave\tO\na\tO\nhigh\tO\nincidence\tO\nof\tO\nunderlying\tO\nsignificant\tO\ndisease\tO\n.\tO\n\nTroponin\tO\nappears\tO\nto\tO\nhave\tO\nan\tO\nequivalent\tO\ndiagnostic\tO\naccuracy\tO\ncompared\tO\nwith\tO\nCK\tO\n-\tO\nMB\tO\nfor\tO\ndiagnosing\tO\nnecrosis\tB-Disease\nin\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\nand\tO\nsuspected\tO\nMI\tB-Disease\n.\tO\n\nAcute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\ndue\tO\nto\tO\nnicergoline\tB-Chemical\n(\tO\nSermion\tB-Chemical\n)\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\n(\tO\nAIN\tB-Disease\n)\tO\ndue\tO\nto\tO\nnicergoline\tB-Chemical\n(\tO\nSermion\tB-Chemical\n)\tO\n.\tO\n\nA\tO\n50\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\nadmitted\tO\nto\tO\nour\tO\nhospital\tO\nfor\tO\nfever\tB-Disease\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nBefore\tO\nadmission\tO\n,\tO\nhe\tO\nhad\tO\nbeen\tO\ntaking\tO\nnicergoline\tB-Chemical\nand\tO\nbendazac\tB-Chemical\nlysine\tI-Chemical\ndue\tO\nto\tO\nretinal\tB-Disease\nvein\tI-Disease\nocclusion\tI-Disease\nat\tO\nophthalmologic\tO\ndepartment\tO\n.\tO\n\nThereafter\tO\n,\tO\nhe\tO\nexperienced\tO\nintermittent\tO\nfever\tB-Disease\nand\tO\nskin\tB-Disease\nrash\tI-Disease\n.\tO\n\nOn\tO\nadmission\tO\n,\tO\nclinical\tO\nsymptoms\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\narthralgia\tB-Disease\nand\tO\nfever\tB-Disease\n)\tO\nand\tO\nlaboratory\tO\nfindings\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\neosinophilia\tB-Disease\nand\tO\nrenal\tB-Disease\nfailure\tI-Disease\n)\tO\nsuggested\tO\nAIN\tB-Disease\n,\tO\nand\tO\nwhich\tO\nwas\tO\nconfirmed\tO\nby\tO\npathologic\tO\nfindings\tO\non\tO\nrenal\tO\nbiopsy\tO\n.\tO\n\nA\tO\nlymphocyte\tO\ntransformation\tO\ntest\tO\ndemonstrated\tO\na\tO\npositive\tO\nresult\tO\nagainst\tO\nnicergoline\tB-Chemical\n.\tO\n\nTreatment\tO\nwas\tO\nconsisted\tO\nof\tO\nwithdrawal\tO\nof\tO\nnicergoline\tB-Chemical\nand\tO\nintravenous\tO\nmethylprednisolone\tB-Chemical\n,\tO\nand\tO\nhis\tO\nrenal\tO\nfunction\tO\nwas\tO\ncompletely\tO\nrecovered\tO\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\nreport\tO\nof\tO\nnicergoline\tB-Chemical\n-\tO\nassociated\tO\nAIN\tB-Disease\n.\tO\n\nNeuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\ncomplicated\tO\nby\tO\nmassive\tO\nintestinal\tO\nbleeding\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nA\tO\npatient\tO\nwith\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n(\tO\nCRF\tB-Disease\n)\tO\ndeveloped\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\n(\tO\nNMS\tB-Disease\n)\tO\nafter\tO\nadministration\tO\nof\tO\nrisperidone\tB-Chemical\nand\tO\nlevomepromazine\tB-Chemical\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nthe\tO\ntypical\tO\nsymptoms\tO\nof\tO\nNMS\tB-Disease\n,\tO\nmassive\tO\nintestinal\tO\nbleeding\tB-Disease\nwas\tO\nobserved\tO\nduring\tO\nthe\tO\nepisode\tO\n.\tO\n\nThis\tO\nreport\tO\nsuggests\tO\nthat\tO\nNMS\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nCRF\tB-Disease\nmay\tO\nbe\tO\ncomplicated\tO\nby\tO\nintestinal\tO\nbleeding\tB-Disease\nand\tO\nneeds\tO\nspecial\tO\ncaution\tO\nfor\tO\nthis\tO\ncomplication\tO\n.\tO\n\nBlood\tO\nbrain\tO\nbarrier\tO\nin\tO\nright\tO\n-\tO\nand\tO\nleft\tO\n-\tO\npawed\tO\nfemale\tO\nrats\tO\nassessed\tO\nby\tO\na\tO\nnew\tO\nstaining\tO\nmethod\tO\n.\tO\n\nThe\tO\nasymmetrical\tO\nbreakdown\tO\nof\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n(\tO\nBBB\tO\n)\tO\nwas\tO\nstudied\tO\nin\tO\nfemale\tO\nrats\tO\n.\tO\n\nPaw\tO\npreference\tO\nwas\tO\nassessed\tO\nby\tO\na\tO\nfood\tO\nreaching\tO\ntest\tO\n.\tO\n\nAdrenaline\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nwas\tO\nused\tO\nto\tO\ndestroy\tO\nthe\tO\nBBB\tO\n,\tO\nwhich\tO\nwas\tO\nevaluated\tO\nusing\tO\ntriphenyltetrazolium\tB-Chemical\n(\tO\nTTC\tB-Chemical\n)\tO\nstaining\tO\nof\tO\nthe\tO\nbrain\tO\nslices\tO\njust\tO\nafter\tO\ngiving\tO\nadrenaline\tB-Chemical\nfor\tO\n30\tO\ns\tO\n.\tO\n\nIn\tO\nnormal\tO\nrats\tO\n,\tO\nthe\tO\nwhole\tO\nbrain\tO\nsections\tO\nexhibited\tO\ncomplete\tO\nstaining\tO\nwith\tO\nTTC\tB-Chemical\n.\tO\n\nAfter\tO\nadrenaline\tB-Chemical\ninfusion\tO\nfor\tO\n30\tO\ns\tO\n,\tO\nthere\tO\nwere\tO\nlarge\tO\nunstained\tO\nareas\tO\nin\tO\nthe\tO\nleft\tO\nbrain\tO\nin\tO\nright\tO\n-\tO\npawed\tO\nanimals\tO\n,\tO\nand\tO\nvice\tO\nversa\tO\nin\tO\nleft\tO\n-\tO\npawed\tO\nanimals\tO\n.\tO\n\nSimilar\tO\nresults\tO\nwere\tO\nobtained\tO\nin\tO\nseizure\tB-Disease\n-\tO\ninduced\tO\nbreakdown\tO\nof\tO\nBBB\tO\n.\tO\n\nThese\tO\nresults\tO\nwere\tO\nexplained\tO\nby\tO\nan\tO\nasymmetric\tO\ncerebral\tO\nblood\tO\nflow\tO\ndepending\tO\nupon\tO\nthe\tO\npaw\tO\npreference\tO\nin\tO\nrats\tO\n.\tO\n\nIt\tO\nwas\tO\nsuggested\tO\nthat\tO\nthis\tO\nnew\tO\nmethod\tO\nand\tO\nthe\tO\nresults\tO\nare\tO\nconsistent\tO\nwith\tO\ncontralateral\tO\nmotor\tO\ncontrol\tO\nthat\tO\nmay\tO\nbe\tO\nimportant\tO\nin\tO\ndetermining\tO\nthe\tO\ndominant\tO\ncerebral\tO\nhemisphere\tO\nin\tO\nanimals\tO\n.\tO\n\nCarvedilol\tB-Chemical\nprotects\tO\nagainst\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\nmitochondrial\tO\ncardiomyopathy\tB-Disease\n.\tO\n\nSeveral\tO\ncytopathic\tO\nmechanisms\tO\nhave\tO\nbeen\tO\nsuggested\tO\nto\tO\nmediate\tO\nthe\tO\ndose\tO\n-\tO\nlimiting\tO\ncumulative\tO\nand\tO\nirreversible\tO\ncardiomyopathy\tB-Disease\ncaused\tO\nby\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nRecent\tO\nevidence\tO\nindicates\tO\nthat\tO\noxidative\tO\nstress\tO\nand\tO\nmitochondrial\tB-Disease\ndysfunction\tI-Disease\nare\tO\nkey\tO\nfactors\tO\nin\tO\nthe\tO\npathogenic\tO\nprocess\tO\n.\tO\n\nThe\tO\nobjective\tO\nof\tO\nthis\tO\ninvestigation\tO\nwas\tO\nto\tO\ntest\tO\nthe\tO\nhypothesis\tO\nthat\tO\ncarvedilol\tB-Chemical\n,\tO\na\tO\nnonselective\tO\nbeta\tO\n-\tO\nadrenergic\tO\nreceptor\tO\nantagonist\tO\nwith\tO\npotent\tO\nantioxidant\tO\nproperties\tO\n,\tO\nprotects\tO\nagainst\tO\nthe\tO\ncardiac\tO\nand\tO\nhepatic\tO\nmitochondrial\tO\nbioenergetic\tO\ndysfunction\tO\nassociated\tO\nwith\tO\nsubchronic\tO\ndoxorubicin\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nHeart\tO\nand\tO\nliver\tO\nmitochondria\tO\nwere\tO\nisolated\tO\nfrom\tO\nrats\tO\ntreated\tO\nfor\tO\n7\tO\nweeks\tO\nwith\tO\ndoxorubicin\tB-Chemical\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n/\tO\nweek\tO\n)\tO\n,\tO\ncarvedilol\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n/\tO\nweek\tO\n)\tO\n,\tO\nor\tO\nthe\tO\ncombination\tO\nof\tO\nthe\tO\ntwo\tO\ndrugs\tO\n.\tO\n\nHeart\tO\nmitochondria\tO\nisolated\tO\nfrom\tO\ndoxorubicin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nexhibited\tO\ndepressed\tO\nrates\tO\nfor\tO\nstate\tO\n3\tO\nrespiration\tO\n(\tO\n336\tO\n+\tO\n/\tO\n-\tO\n26\tO\nversus\tO\n425\tO\n+\tO\n/\tO\n-\tO\n53\tO\nnatom\tO\nO\tO\n/\tO\nmin\tO\n/\tO\nmg\tO\nprotein\tO\n)\tO\nand\tO\na\tO\nlower\tO\nrespiratory\tO\ncontrol\tO\nratio\tO\n(\tO\nRCR\tO\n)\tO\n(\tO\n4\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n6\tO\nversus\tO\n5\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n4\tO\n)\tO\ncompared\tO\nwith\tO\ncardiac\tO\nmitochondria\tO\nisolated\tO\nfrom\tO\nsaline\tO\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nMitochondrial\tO\ncalcium\tB-Chemical\n-\tO\nloading\tO\ncapacity\tO\nand\tO\nthe\tO\nactivity\tO\nof\tO\nNADH\tO\n-\tO\ndehydrogenase\tO\nwere\tO\nalso\tO\nsuppressed\tO\nin\tO\ncardiac\tO\nmitochondria\tO\nfrom\tO\ndoxorubicin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nDoxorubicin\tB-Chemical\ntreatment\tO\nalso\tO\ncaused\tO\na\tO\ndecrease\tO\nin\tO\nRCR\tO\nfor\tO\nliver\tO\nmitochondria\tO\n(\tO\n3\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n9\tO\nversus\tO\n5\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\nfor\tO\ncontrol\tO\nrats\tO\n)\tO\nand\tO\ninhibition\tO\nof\tO\nhepatic\tO\ncytochrome\tO\noxidase\tO\nactivity\tO\n.\tO\n\nCoadministration\tO\nof\tO\ncarvedilol\tB-Chemical\ndecreased\tO\nthe\tO\nextent\tO\nof\tO\ncellular\tO\nvacuolization\tO\nin\tO\ncardiac\tO\nmyocytes\tO\nand\tO\nprevented\tO\nthe\tO\ninhibitory\tO\neffect\tO\nof\tO\ndoxorubicin\tB-Chemical\non\tO\nmitochondrial\tO\nrespiration\tO\nin\tO\nboth\tO\nheart\tO\nand\tO\nliver\tO\n.\tO\n\nCarvedilol\tB-Chemical\nalso\tO\nprevented\tO\nthe\tO\ndecrease\tO\nin\tO\nmitochondrial\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nloading\tO\ncapacity\tO\nand\tO\nthe\tO\ninhibition\tO\nof\tO\nthe\tO\nrespiratory\tO\ncomplexes\tO\nof\tO\nheart\tO\nmitochondria\tO\ncaused\tO\nby\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nCarvedilol\tB-Chemical\nby\tO\nitself\tO\ndid\tO\nnot\tO\naffect\tO\nany\tO\nof\tO\nthe\tO\nparameters\tO\nmeasured\tO\nfor\tO\nheart\tO\nor\tO\nliver\tO\nmitochondria\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nthis\tO\nprotection\tO\nby\tO\ncarvedilol\tB-Chemical\nagainst\tO\nboth\tO\nthe\tO\nstructural\tO\nand\tO\nfunctional\tO\ncardiac\tO\ntissue\tO\ndamage\tO\nmay\tO\nafford\tO\nsignificant\tO\nclinical\tO\nadvantage\tO\nin\tO\nminimizing\tO\nthe\tO\ndose\tO\n-\tO\nlimiting\tO\nmitochondrial\tB-Disease\ndysfunction\tI-Disease\nand\tO\ncardiomyopathy\tB-Disease\nthat\tO\naccompanies\tO\nlong\tO\n-\tO\nterm\tO\ndoxorubicin\tB-Chemical\ntherapy\tO\nin\tO\ncancer\tB-Disease\npatients\tO\n.\tO\n\nCocaine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nis\tO\nmore\tO\ninfluenced\tO\nby\tO\nadenosine\tB-Chemical\nreceptor\tO\nagonists\tO\nthan\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n.\tO\n\nThe\tO\ninfluence\tO\nof\tO\nadenosine\tB-Chemical\nreceptor\tO\nagonists\tO\nand\tO\nantagonists\tO\non\tO\ncocaine\tB-Chemical\n-\tO\nand\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nwas\tO\nexamined\tO\nin\tO\nmice\tO\n.\tO\n\nAll\tO\nadenosine\tB-Chemical\nreceptor\tO\nagonists\tO\nsignificantly\tO\ndecreased\tB-Disease\nthe\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nin\tO\nmice\tO\n,\tO\nand\tO\nthe\tO\neffects\tO\nwere\tO\ndose\tO\n-\tO\ndependent\tO\n.\tO\n\nIt\tO\nseems\tO\nthat\tO\nadenosine\tB-Chemical\nA1\tO\nand\tO\nA2\tO\nreceptors\tO\nmight\tO\nbe\tO\ninvolved\tO\nin\tO\nthis\tO\nreaction\tO\n.\tO\n\nMoreover\tO\n,\tO\nall\tO\nadenosine\tB-Chemical\nreceptor\tO\nagonists\tO\n:\tO\n2\tB-Chemical\n-\tI-Chemical\np\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ncarboxyethyl\tI-Chemical\n)\tI-Chemical\nphenethylamino\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\nethylcarboxamidoadenosine\tI-Chemical\n(\tO\nCGS\tB-Chemical\n21680\tI-Chemical\n)\tO\n,\tO\nA2A\tO\nreceptor\tO\nagonist\tO\n,\tO\nN6\tB-Chemical\n-\tI-Chemical\ncyclopentyladenosine\tI-Chemical\n(\tO\nCPA\tB-Chemical\n)\tO\n,\tO\nA1\tO\nreceptor\tO\nagonist\tO\n,\tO\nand\tO\n5\tB-Chemical\n'\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\nethylcarboxamidoadenosine\tI-Chemical\n(\tO\nNECA\tB-Chemical\n)\tO\n,\tO\nA2\tO\n/\tO\nA1\tO\nreceptor\tO\nagonist\tO\nsignificantly\tO\nand\tO\ndose\tO\n-\tO\ndependently\tO\ndecreased\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nactivity\tO\n.\tO\n\nCPA\tB-Chemical\nreduced\tO\ncocaine\tB-Chemical\naction\tO\nat\tO\nthe\tO\ndoses\tO\nwhich\tO\n,\tO\ngiven\tO\nalone\tO\n,\tO\ndid\tO\nnot\tO\ninfluence\tO\nmotility\tO\n,\tO\nwhile\tO\nCGS\tB-Chemical\n21680\tI-Chemical\nand\tO\nNECA\tB-Chemical\ndecreased\tO\nthe\tO\naction\tO\nof\tO\ncocaine\tB-Chemical\nat\tO\nthe\tO\ndoses\tO\nwhich\tO\n,\tO\ngiven\tO\nalone\tO\n,\tO\ndecreased\tO\nlocomotor\tO\nactivity\tO\nin\tO\nanimals\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthe\tO\ninvolvement\tO\nof\tO\nboth\tO\nadenosine\tB-Chemical\nreceptors\tO\nin\tO\nthe\tO\naction\tO\nof\tO\ncocaine\tB-Chemical\nalthough\tO\nagonists\tO\nof\tO\nA1\tO\nreceptors\tO\nseem\tO\nto\tO\nhave\tO\nstronger\tO\ninfluence\tO\non\tO\nit\tO\n.\tO\n\nThe\tO\nselective\tO\nblockade\tO\nof\tO\nA2\tO\nadenosine\tB-Chemical\nreceptor\tO\nby\tO\nDMPX\tB-Chemical\n(\tO\n3\tB-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\ndimethyl\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\npropargylxanthine\tI-Chemical\n)\tO\nsignificantly\tO\nenhanced\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nactivity\tO\nof\tO\nanimals\tO\n.\tO\n\nCaffeine\tB-Chemical\nhad\tO\nsimilar\tO\naction\tO\nbut\tO\nthe\tO\neffect\tO\nwas\tO\nnot\tO\nsignificant\tO\n.\tO\n\nCPT\tB-Chemical\n(\tO\n8\tB-Chemical\n-\tI-Chemical\ncyclopentyltheophylline\tI-Chemical\n)\tO\n-\tO\n-\tO\nA1\tO\nreceptor\tO\nantagonist\tO\n,\tO\ndid\tO\nnot\tO\nshow\tO\nany\tO\ninfluence\tO\nin\tO\nthis\tO\ntest\tO\n.\tO\n\nSimilarly\tO\n,\tO\nall\tO\nadenosine\tB-Chemical\nreceptor\tO\nagonists\tO\ndecreased\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n,\tO\nbut\tO\nat\tO\nthe\tO\nhigher\tO\ndoses\tO\nthan\tO\nthose\tO\nwhich\tO\nwere\tO\nactive\tO\nin\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n.\tO\n\nThe\tO\nselective\tO\nblockade\tO\nof\tO\nA2\tO\nadenosine\tB-Chemical\nreceptors\tO\n(\tO\nDMPX\tB-Chemical\n)\tO\nand\tO\nnon\tO\n-\tO\nselective\tO\nblockade\tO\nof\tO\nadenosine\tB-Chemical\nreceptors\tO\n(\tO\ncaffeine\tB-Chemical\n)\tO\nsignificantly\tO\nincreased\tO\nthe\tO\naction\tO\nof\tO\namphetamine\tB-Chemical\nin\tO\nthe\tO\nlocomotor\tO\nactivity\tO\ntest\tO\n.\tO\n\nOur\tO\nresults\tO\nhave\tO\nshown\tO\nthat\tO\nall\tO\nadenosine\tB-Chemical\nreceptor\tO\nagonists\tO\n(\tO\nA1\tO\nand\tO\nA2\tO\n)\tO\nreduce\tO\ncocaine\tB-Chemical\n-\tO\nand\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nactivity\tO\nand\tO\nindicate\tO\nthat\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nis\tO\nmore\tO\ninfluenced\tO\nby\tO\nadenosine\tB-Chemical\nreceptor\tO\nagonists\tO\n(\tO\nparticularly\tO\nA1\tO\nreceptors\tO\n)\tO\nthan\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n.\tO\n\nAmiodarone\tB-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nbradyarrhythmia\tB-Disease\nrequiring\tO\npermanent\tO\npacemaker\tO\nin\tO\nelderly\tO\npatients\tO\nwith\tO\natrial\tB-Disease\nfibrillation\tI-Disease\nand\tO\nprior\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nwhether\tO\nthe\tO\nuse\tO\nof\tO\namiodarone\tB-Chemical\nin\tO\npatients\tO\nwith\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n(\tO\nAF\tB-Disease\n)\tO\nincreases\tO\nthe\tO\nrisk\tO\nof\tO\nbradyarrhythmia\tB-Disease\nrequiring\tO\na\tO\npermanent\tO\npacemaker\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nReports\tO\nof\tO\nsevere\tO\nbradyarrhythmia\tB-Disease\nduring\tO\namiodarone\tB-Chemical\ntherapy\tO\nare\tO\ninfrequent\tO\nand\tO\nlimited\tO\nto\tO\nstudies\tO\nassessing\tO\nthe\tO\ntherapy\tO\n'\tO\ns\tO\nuse\tO\nin\tO\nthe\tO\nmanagement\tO\nof\tO\npatients\tO\nwith\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nstudy\tO\ncohort\tO\nof\tO\n8\tO\n,\tO\n770\tO\npatients\tO\nage\tO\n>\tO\nor\tO\n=\tO\n65\tO\nyears\tO\nwith\tO\na\tO\nnew\tO\ndiagnosis\tO\nof\tO\nAF\tB-Disease\nwas\tO\nidentified\tO\nfrom\tO\na\tO\nprovincewide\tO\ndatabase\tO\nof\tO\nQuebec\tO\nresidents\tO\nwith\tO\na\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n(\tO\nMI\tB-Disease\n)\tO\nbetween\tO\n1991\tO\nand\tO\n1999\tO\n.\tO\n\nUsing\tO\na\tO\nnested\tO\ncase\tO\n-\tO\ncontrol\tO\ndesign\tO\n,\tO\n477\tO\ncases\tO\nof\tO\nbradyarrhythmia\tB-Disease\nrequiring\tO\na\tO\npermanent\tO\npacemaker\tO\nwere\tO\nmatched\tO\n(\tO\n1\tO\n:\tO\n4\tO\n)\tO\nto\tO\n1\tO\n,\tO\n908\tO\ncontrols\tO\n.\tO\n\nMultivariable\tO\nlogistic\tO\nregression\tO\nwas\tO\nused\tO\nto\tO\nestimate\tO\nthe\tO\nodds\tO\nratio\tO\n(\tO\nOR\tO\n)\tO\nof\tO\npacemaker\tO\ninsertion\tO\nassociated\tO\nwith\tO\namiodarone\tB-Chemical\nuse\tO\n,\tO\ncontrolling\tO\nfor\tO\nbaseline\tO\nrisk\tO\nfactors\tO\nand\tO\nexposure\tO\nto\tO\nsotalol\tB-Chemical\n,\tO\nClass\tO\nI\tO\nantiarrhythmic\tO\nagents\tO\n,\tO\nbeta\tO\n-\tO\nblockers\tO\n,\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\n,\tO\nand\tO\ndigoxin\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\namiodarone\tB-Chemical\nuse\tO\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\npacemaker\tO\ninsertion\tO\n(\tO\nOR\tO\n:\tO\n2\tO\n.\tO\n14\tO\n,\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n:\tO\n1\tO\n.\tO\n30\tO\nto\tO\n3\tO\n.\tO\n54\tO\n)\tO\n.\tO\n\nThis\tO\neffect\tO\nwas\tO\nmodified\tO\nby\tO\ngender\tO\n,\tO\nwith\tO\na\tO\ngreater\tO\nrisk\tO\nin\tO\nwomen\tO\nversus\tO\nmen\tO\n(\tO\nOR\tO\n:\tO\n3\tO\n.\tO\n86\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n1\tO\n.\tO\n70\tO\nto\tO\n8\tO\n.\tO\n75\tO\nvs\tO\n.\tO\nOR\tO\n:\tO\n1\tO\n.\tO\n52\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n80\tO\nto\tO\n2\tO\n.\tO\n89\tO\n)\tO\n.\tO\n\nDigoxin\tB-Chemical\nwas\tO\nthe\tO\nonly\tO\nother\tO\nmedication\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\npacemaker\tO\ninsertion\tO\n(\tO\nOR\tO\n:\tO\n1\tO\n.\tO\n78\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n1\tO\n.\tO\n37\tO\nto\tO\n2\tO\n.\tO\n31\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThis\tO\nstudy\tO\nsuggests\tO\nthat\tO\nthe\tO\nuse\tO\nof\tO\namiodarone\tB-Chemical\nin\tO\nelderly\tO\npatients\tO\nwith\tO\nAF\tB-Disease\nand\tO\na\tO\nprevious\tO\nMI\tB-Disease\nincreases\tO\nthe\tO\nrisk\tO\nof\tO\nbradyarrhythmia\tB-Disease\nrequiring\tO\na\tO\npermanent\tO\npacemaker\tO\n.\tO\n\nThe\tO\nfinding\tO\nof\tO\nan\tO\naugmented\tO\nrisk\tO\nof\tO\npacemaker\tO\ninsertion\tO\nin\tO\nelderly\tO\nwomen\tO\nreceiving\tO\namiodarone\tB-Chemical\nrequires\tO\nfurther\tO\ninvestigation\tO\n.\tO\n\nIndomethacin\tB-Chemical\n-\tO\ninduced\tO\nmorphologic\tO\nchanges\tO\nin\tO\nthe\tO\nrat\tO\nurinary\tO\nbladder\tO\nepithelium\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nmorphologic\tO\nchanges\tO\nin\tO\nrat\tO\nurothelium\tO\ninduced\tO\nby\tO\nindomethacin\tB-Chemical\n.\tO\n\nNonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrug\tO\n-\tO\ninduced\tO\ncystitis\tB-Disease\nis\tO\na\tO\npoorly\tO\nrecognized\tO\nand\tO\nunder\tO\n-\tO\nreported\tO\ncondition\tO\n.\tO\n\nIn\tO\naddition\tO\nto\tO\ntiaprofenic\tB-Chemical\nacid\tI-Chemical\n,\tO\nindomethacin\tB-Chemical\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nthis\tO\ncondition\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThree\tO\ngroups\tO\nwere\tO\nestablished\tO\n:\tO\na\tO\ncontrol\tO\ngroup\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\n,\tO\na\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\n,\tO\ntreated\tO\nwith\tO\none\tO\nintraperitoneal\tO\ninjection\tO\nof\tO\nindomethacin\tB-Chemical\n20\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nand\tO\na\tO\ntherapeutic\tO\ndose\tO\ngroup\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\nin\tO\nwhich\tO\noral\tO\nindomethacin\tB-Chemical\nwas\tO\nadministered\tO\n3\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\ndaily\tO\nfor\tO\n3\tO\nweeks\tO\n.\tO\n\nThe\tO\nanimals\tO\nwere\tO\nthen\tO\nkilled\tO\nand\tO\nthe\tO\nbladders\tO\nremoved\tO\nfor\tO\nlight\tO\nand\tO\nelectron\tO\nmicroscopic\tO\nstudies\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nlight\tO\nmicroscopic\tO\nfindings\tO\nshowed\tO\nsome\tO\nfocal\tO\nepithelial\tO\ndegeneration\tO\nthat\tO\nwas\tO\nmore\tO\nprominent\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\n.\tO\n\nWhen\tO\ncompared\tO\nwith\tO\nthe\tO\ncontrol\tO\ngroup\tO\n,\tO\nboth\tO\nindomethacin\tB-Chemical\ngroups\tO\nrevealed\tO\nstatistically\tO\nincreased\tO\nnumbers\tO\nof\tO\nmast\tO\ncells\tO\nin\tO\nthe\tO\nmucosa\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\nand\tO\npenetration\tO\nof\tO\nlanthanum\tB-Chemical\nnitrate\tI-Chemical\nthrough\tO\nintercellular\tO\nareas\tO\nof\tO\nthe\tO\nepithelium\tO\n.\tO\n\nFurthermore\tO\n,\tO\nthe\tO\ndifference\tO\nin\tO\nmast\tO\ncell\tO\ncounts\tO\nbetween\tO\nthe\tO\nhigh\tO\nand\tO\ntherapeutic\tO\ndose\tO\ngroups\tO\nwas\tO\nalso\tO\nstatistically\tO\nsignificant\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIndomethacin\tB-Chemical\nresulted\tO\nin\tO\nhistopathologic\tO\nfindings\tO\ntypical\tO\nof\tO\ninterstitial\tB-Disease\ncystitis\tI-Disease\n,\tO\nsuch\tO\nas\tO\nleaky\tO\nbladder\tO\nepithelium\tO\nand\tO\nmucosal\tO\nmastocytosis\tB-Disease\n.\tO\n\nThe\tO\ntrue\tO\nincidence\tO\nof\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrug\tO\n-\tO\ninduced\tO\ncystitis\tB-Disease\nin\tO\nhumans\tO\nmust\tO\nbe\tO\nclarified\tO\nby\tO\nprospective\tO\nclinical\tO\ntrials\tO\n.\tO\n\nAn\tO\nopen\tO\n-\tO\nlabel\tO\nphase\tO\nII\tO\nstudy\tO\nof\tO\nlow\tO\n-\tO\ndose\tO\nthalidomide\tB-Chemical\nin\tO\nandrogen\tB-Chemical\n-\tO\nindependent\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nThe\tO\nantiangiogenic\tO\neffects\tO\nof\tO\nthalidomide\tB-Chemical\nhave\tO\nbeen\tO\nassessed\tO\nin\tO\nclinical\tO\ntrials\tO\nin\tO\npatients\tO\nwith\tO\nvarious\tO\nsolid\tO\nand\tO\nhaematological\tB-Disease\nmalignancies\tI-Disease\n.\tO\n\nThalidomide\tB-Chemical\nblocks\tO\nthe\tO\nactivity\tO\nof\tO\nangiogenic\tO\nagents\tO\nincluding\tO\nbFGF\tO\n,\tO\nVEGF\tO\nand\tO\nIL\tO\n-\tO\n6\tO\n.\tO\n\nWe\tO\nundertook\tO\nan\tO\nopen\tO\n-\tO\nlabel\tO\nstudy\tO\nusing\tO\nthalidomide\tB-Chemical\n100\tO\nmg\tO\nonce\tO\ndaily\tO\nfor\tO\nup\tO\nto\tO\n6\tO\nmonths\tO\nin\tO\n20\tO\nmen\tO\nwith\tO\nandrogen\tB-Chemical\n-\tO\nindependent\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nThe\tO\nmean\tO\ntime\tO\nof\tO\nstudy\tO\nwas\tO\n109\tO\ndays\tO\n(\tO\nmedian\tO\n107\tO\n,\tO\nrange\tO\n4\tO\n-\tO\n184\tO\ndays\tO\n)\tO\n.\tO\n\nPatients\tO\nunderwent\tO\nregular\tO\nmeasurement\tO\nof\tO\nprostate\tO\n-\tO\nspecific\tO\nantigen\tO\n(\tO\nPSA\tO\n)\tO\n,\tO\nurea\tB-Chemical\nand\tO\nelectrolytes\tO\n,\tO\nserum\tO\nbFGF\tO\nand\tO\nVEGF\tO\n.\tO\n\nThree\tO\nmen\tO\n(\tO\n15\tO\n%\tO\n)\tO\nshowed\tO\na\tO\ndecline\tO\nin\tO\nserum\tO\nPSA\tO\nof\tO\nat\tO\nleast\tO\n50\tO\n%\tO\n,\tO\nsustained\tO\nthroughout\tO\ntreatment\tO\n.\tO\n\nOf\tO\n16\tO\nmen\tO\ntreated\tO\nfor\tO\nat\tO\nleast\tO\n2\tO\nmonths\tO\n,\tO\nsix\tO\n(\tO\n37\tO\n.\tO\n5\tO\n%\tO\n)\tO\nshowed\tO\na\tO\nfall\tO\nin\tO\nabsolute\tO\nPSA\tO\nby\tO\na\tO\nmedian\tO\nof\tO\n48\tO\n%\tO\n.\tO\n\nIncreasing\tO\nlevels\tO\nof\tO\nserum\tO\nbFGF\tO\nand\tO\nVEGF\tO\nwere\tO\nassociated\tO\nwith\tO\nprogressive\tO\ndisease\tO\n;\tO\nfive\tO\nof\tO\nsix\tO\nmen\tO\nwho\tO\ndemonstrated\tO\na\tO\nfall\tO\nin\tO\nPSA\tO\nalso\tO\nshowed\tO\na\tO\ndecline\tO\nin\tO\nbFGF\tO\nand\tO\nVEGF\tO\nlevels\tO\n,\tO\nand\tO\nthree\tO\nof\tO\nfour\tO\nmen\tO\nwith\tO\na\tO\nrising\tO\nPSA\tO\nshowed\tO\nan\tO\nincrease\tO\nin\tO\nboth\tO\ngrowth\tO\nfactors\tO\n.\tO\n\nAdverse\tO\neffects\tO\nincluded\tO\nconstipation\tB-Disease\n,\tO\nmorning\tO\ndrowsiness\tB-Disease\n,\tO\ndizziness\tB-Disease\nand\tO\nrash\tB-Disease\n,\tO\nand\tO\nresulted\tO\nin\tO\nwithdrawal\tO\nfrom\tO\nthe\tO\nstudy\tO\nby\tO\nthree\tO\nmen\tO\n.\tO\n\nEvidence\tO\nof\tO\nperipheral\tB-Disease\nsensory\tI-Disease\nneuropathy\tI-Disease\nwas\tO\nfound\tO\nin\tO\nnine\tO\nof\tO\n13\tO\nmen\tO\nbefore\tO\ntreatment\tO\n.\tO\n\nIn\tO\nthe\tO\nseven\tO\nmen\tO\nwho\tO\ncompleted\tO\nsix\tO\nmonths\tO\non\tO\nthalidomide\tB-Chemical\n,\tO\nsubclinical\tO\nevidence\tO\nof\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\nwas\tO\nfound\tO\nin\tO\nfour\tO\nbefore\tO\ntreatment\tO\n,\tO\nbut\tO\nin\tO\nall\tO\nseven\tO\nat\tO\nrepeat\tO\ntesting\tO\n.\tO\n\nThe\tO\nfindings\tO\nindicate\tO\nthat\tO\nthalidomide\tB-Chemical\nmay\tO\nbe\tO\nan\tO\noption\tO\nfor\tO\npatients\tO\nwho\tO\nhave\tO\nfailed\tO\nother\tO\nforms\tO\nof\tO\ntherapy\tO\n,\tO\nprovided\tO\nclose\tO\nfollow\tO\n-\tO\nup\tO\nis\tO\nmaintained\tO\nfor\tO\ndevelopment\tO\nof\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nCentral\tB-Disease\nnervous\tI-Disease\nsystem\tI-Disease\ntoxicity\tI-Disease\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nlevobupivacaine\tB-Chemical\nfor\tO\nlumbar\tO\nplexus\tO\nblock\tO\n:\tO\nA\tO\nreport\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nBACKGROUND\tO\nAND\tO\nOBJECTIVES\tO\n:\tO\nCentral\tB-Disease\nnervous\tI-Disease\nsystem\tI-Disease\nand\tI-Disease\ncardiac\tI-Disease\ntoxicity\tI-Disease\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nlocal\tO\nanesthetics\tO\nis\tO\na\tO\nrecognized\tO\ncomplication\tO\nof\tO\nregional\tO\nanesthesia\tO\n.\tO\n\nLevobupivacaine\tB-Chemical\n,\tO\nthe\tO\npure\tO\nS\tO\n(\tO\n-\tO\n)\tO\nenantiomer\tO\nof\tO\nbupivacaine\tB-Chemical\n,\tO\nwas\tO\ndeveloped\tO\nto\tO\nimprove\tO\nthe\tO\ncardiac\tO\nsafety\tO\nprofile\tO\nof\tO\nbupivacaine\tB-Chemical\n.\tO\n\nWe\tO\ndescribe\tO\n2\tO\ncases\tO\nof\tO\ngrand\tB-Disease\nmal\tI-Disease\nseizures\tI-Disease\nfollowing\tO\naccidental\tO\nintravascular\tO\ninjection\tO\nof\tO\nlevobupivacaine\tB-Chemical\n.\tO\n\nCASE\tO\nREPORT\tO\n:\tO\nTwo\tO\npatients\tO\npresenting\tO\nfor\tO\nelective\tO\northopedic\tO\nsurgery\tO\nof\tO\nthe\tO\nlower\tO\nlimb\tO\nunderwent\tO\nblockade\tO\nof\tO\nthe\tO\nlumbar\tO\nplexus\tO\nvia\tO\nthe\tO\nposterior\tO\napproach\tO\n.\tO\n\nImmediately\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\nlevobupivacaine\tB-Chemical\n0\tO\n.\tO\n5\tO\n%\tO\nwith\tO\nepinephrine\tB-Chemical\n2\tO\n.\tO\n5\tO\nmicrogram\tO\n/\tO\nmL\tO\n,\tO\nthe\tO\npatients\tO\ndeveloped\tO\ngrand\tB-Disease\nmal\tI-Disease\nseizures\tI-Disease\n,\tO\ndespite\tO\nnegative\tO\naspiration\tO\nfor\tO\nblood\tO\nand\tO\nno\tO\nclinical\tO\nsigns\tO\nof\tO\nintravenous\tO\nepinephrine\tB-Chemical\nadministration\tO\n.\tO\n\nThe\tO\nseizures\tB-Disease\nwere\tO\nsuccessfully\tO\ntreated\tO\nwith\tO\nsodium\tB-Chemical\nthiopental\tI-Chemical\nin\tO\naddition\tO\nto\tO\nsuccinylcholine\tB-Chemical\nin\tO\n1\tO\npatient\tO\n.\tO\n\nNeither\tO\npatient\tO\ndeveloped\tO\nsigns\tO\nof\tO\ncardiovascular\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nBoth\tO\npatients\tO\nwere\tO\ntreated\tO\npreoperatively\tO\nwith\tO\nbeta\tO\n-\tO\nadrenergic\tO\nantagonist\tO\nmedications\tO\n,\tO\nwhich\tO\nmay\tO\nhave\tO\nmasked\tO\nthe\tO\ncardiovascular\tO\nsigns\tO\nof\tO\nthe\tO\nunintentional\tO\nintravascular\tO\nadministration\tO\nof\tO\nlevobupivacaine\tB-Chemical\nwith\tO\nepinephrine\tB-Chemical\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAlthough\tO\nlevobupivacaine\tB-Chemical\nmay\tO\nhave\tO\na\tO\nsafer\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nprofile\tO\nthan\tO\nracemic\tO\nbupivacaine\tB-Chemical\n,\tO\nif\tO\nadequate\tO\namounts\tO\nof\tO\nlevobupivacaine\tB-Chemical\nreach\tO\nthe\tO\ncirculation\tO\n,\tO\nit\tO\nwill\tO\nresult\tO\nin\tO\nconvulsions\tB-Disease\n.\tO\n\nPlasma\tO\nconcentrations\tO\nsufficient\tO\nto\tO\nresult\tO\nin\tO\ncentral\tB-Disease\nnervous\tI-Disease\nsystem\tI-Disease\ntoxicity\tI-Disease\ndid\tO\nnot\tO\nproduce\tO\nmanifestations\tO\nof\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nin\tO\nthese\tO\n2\tO\npatients\tO\n.\tO\n\nAmiodarone\tB-Chemical\n-\tO\ninduced\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nduring\tO\nbladder\tO\nirrigation\tO\n:\tO\nan\tO\nunusual\tO\npresentation\tO\n-\tO\n-\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\ncase\tO\nof\tO\nearly\tO\n(\tO\nwithin\tO\n4\tO\ndays\tO\n)\tO\ndevelopment\tO\nof\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\nTdP\tB-Disease\n)\tO\nassociated\tO\nwith\tO\noral\tO\namiodarone\tB-Chemical\ntherapy\tO\n.\tO\n\nConsistent\tO\nwith\tO\nother\tO\nreports\tO\nthis\tO\ncase\tO\nof\tO\nTdP\tB-Disease\noccurred\tO\nin\tO\nthe\tO\ncontext\tO\nof\tO\nmultiple\tO\nexacerbating\tO\nfactors\tO\nincluding\tO\nhypokalemia\tB-Disease\nand\tO\ndigoxin\tB-Chemical\nexcess\tO\n.\tO\n\nTransient\tO\nprolongation\tO\nof\tO\nthe\tO\nQT\tO\nduring\tO\nbladder\tO\nirrigation\tO\nprompted\tO\nthe\tO\nepisode\tO\nof\tO\nTdP\tB-Disease\n.\tO\n\nIt\tO\nis\tO\nwell\tO\nknown\tO\nthat\tO\nbradycardia\tB-Disease\nexacerbates\tO\nacquired\tO\nTdP\tB-Disease\n.\tO\n\nThe\tO\nauthors\tO\nspeculate\tO\nthat\tO\nthe\tO\nincreased\tO\nvagal\tO\ntone\tO\nduring\tO\nbladder\tO\nirrigation\tO\n,\tO\na\tO\nvagal\tO\nmaneuver\tO\n,\tO\nin\tO\nthe\tO\ncontext\tO\nof\tO\namiodarone\tB-Chemical\ntherapy\tO\nresulted\tO\nin\tO\namiodarone\tB-Chemical\n-\tO\ninduced\tO\nproarrhythmia\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\nabsence\tO\nof\tO\namiodarone\tB-Chemical\ntherapy\tO\n,\tO\na\tO\nsecond\tO\nbladder\tO\nirrigation\tO\ndid\tO\nnot\tO\ninduce\tO\nTdP\tB-Disease\ndespite\tO\nhypokalemia\tB-Disease\nand\tO\nhypomagnesemia\tB-Disease\n.\tO\n\nAnaesthetic\tO\ncomplications\tO\nassociated\tO\nwith\tO\nmyotonia\tB-Disease\ncongenita\tI-Disease\n:\tO\ncase\tO\nstudy\tO\nand\tO\ncomparison\tO\nwith\tO\nother\tO\nmyotonic\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nMyotonia\tB-Disease\ncongenita\tI-Disease\n(\tO\nMC\tB-Disease\n)\tO\nis\tO\ncaused\tO\nby\tO\na\tO\ndefect\tO\nin\tO\nthe\tO\nskeletal\tO\nmuscle\tO\nchloride\tB-Chemical\nchannel\tO\nfunction\tO\n,\tO\nwhich\tO\nmay\tO\ncause\tO\nsustained\tB-Disease\nmembrane\tI-Disease\ndepolarisation\tI-Disease\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\npreviously\tO\nhealthy\tO\n32\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwho\tO\ndeveloped\tO\na\tO\nlife\tO\n-\tO\nthreatening\tO\nmuscle\tB-Disease\nspasm\tI-Disease\nand\tO\nsecondary\tO\nventilation\tO\ndifficulties\tO\nfollowing\tO\na\tO\npreoperative\tO\ninjection\tO\nof\tO\nsuxamethonium\tB-Chemical\n.\tO\n\nThe\tO\nmuscle\tB-Disease\nspasms\tI-Disease\ndisappeared\tO\nspontaneously\tO\nand\tO\nthe\tO\nsurgery\tO\nproceeded\tO\nwithout\tO\nfurther\tO\nproblems\tO\n.\tO\n\nWhen\tO\nsubsequently\tO\nquestioned\tO\n,\tO\nshe\tO\nreported\tO\nminor\tO\nsymptoms\tO\nsuggesting\tO\na\tO\nmyotonic\tB-Disease\ncondition\tI-Disease\n.\tO\n\nMyotonia\tB-Disease\nwas\tO\nfound\tO\non\tO\nclinical\tO\nexamination\tO\nand\tO\nEMG\tO\n.\tO\n\nThe\tO\ndiagnosis\tO\nMC\tB-Disease\nwas\tO\nconfirmed\tO\ngenetically\tO\n.\tO\n\nNeither\tO\nthe\tO\npatient\tO\nnor\tO\nthe\tO\nanaesthetist\tO\nwere\tO\naware\tO\nof\tO\nthe\tO\ndiagnosis\tO\nbefore\tO\nthis\tO\npotentially\tO\nlethal\tO\ncomplication\tO\noccurred\tO\n.\tO\n\nWe\tO\ngive\tO\na\tO\nbrief\tO\noverview\tO\nof\tO\nion\tB-Disease\nchannel\tI-Disease\ndisorders\tI-Disease\nincluding\tO\nmalignant\tB-Disease\nhyperthermia\tI-Disease\nand\tO\ntheir\tO\nanaesthetic\tO\nconsiderations\tO\n.\tO\n\nRespiratory\tO\npattern\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nepilepsy\tB-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nApnea\tB-Disease\nis\tO\nknown\tO\nto\tO\noccur\tO\nduring\tO\nseizures\tB-Disease\n,\tO\nbut\tO\nsystematic\tO\nstudies\tO\nof\tO\nictal\tO\nrespiratory\tO\nchanges\tO\nin\tO\nadults\tO\nare\tO\nfew\tO\n.\tO\n\nData\tO\nregarding\tO\nrespiratory\tO\npattern\tO\ndefects\tO\nduring\tO\ninterictal\tO\nperiods\tO\nalso\tO\nare\tO\nscarce\tO\n.\tO\n\nHere\tO\nwe\tO\nsought\tO\nto\tO\ngenerate\tO\ninformation\tO\nwith\tO\nregard\tO\nto\tO\nthe\tO\ninterictal\tO\nperiod\tO\nin\tO\nanimals\tO\nwith\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nepilepsy\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nTwelve\tO\nrats\tO\n(\tO\nsix\tO\nchronically\tO\nepileptic\tB-Disease\nanimals\tO\nand\tO\nsix\tO\ncontrols\tO\n)\tO\nwere\tO\nanesthetized\tO\n,\tO\ngiven\tO\ntracheotomies\tO\n,\tO\nand\tO\nsubjected\tO\nto\tO\nhyperventilation\tB-Disease\nor\tO\nhypoventilation\tO\nconditions\tO\n.\tO\n\nBreathing\tO\nmovements\tO\ncaused\tO\nchanges\tO\nin\tO\nthoracic\tO\nvolume\tO\nand\tO\nforced\tO\nair\tO\nto\tO\nflow\tO\ntidally\tO\nthrough\tO\na\tO\npneumotachograph\tO\n.\tO\n\nThis\tO\nflow\tO\nwas\tO\nmeasured\tO\nby\tO\nusing\tO\na\tO\ndifferential\tO\npressure\tO\ntransducer\tO\n,\tO\npassed\tO\nthrough\tO\na\tO\npolygraph\tO\n,\tO\nand\tO\nfrom\tO\nthis\tO\nto\tO\na\tO\ncomputer\tO\nwith\tO\ncustom\tO\nsoftware\tO\nthat\tO\nderived\tO\nventilation\tO\n(\tO\nVE\tO\n)\tO\n,\tO\ntidal\tO\nvolume\tO\n(\tO\nVT\tO\n)\tO\n,\tO\ninspiratory\tO\ntime\tO\n(\tO\nTI\tO\n)\tO\n,\tO\nexpiratory\tO\ntime\tO\n(\tO\nTE\tO\n)\tO\n,\tO\nbreathing\tO\nfrequency\tO\n(\tO\nf\tO\n)\tO\n,\tO\nand\tO\nmean\tO\ninspiratory\tO\nflow\tO\n(\tO\nVT\tO\n/\tO\nTI\tO\n)\tO\non\tO\na\tO\nbreath\tO\n-\tO\nby\tO\n-\tO\nbreath\tO\nbasis\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nhyperventilation\tB-Disease\nmaneuver\tO\ncaused\tO\na\tO\ndecrease\tO\nin\tO\nspontaneous\tO\nventilation\tO\nin\tO\npilocarpine\tB-Chemical\n-\tO\ntreated\tO\nand\tO\ncontrol\tO\nrats\tO\n.\tO\n\nAlthough\tO\nVE\tO\nhad\tO\na\tO\nsimilar\tO\ndecrease\tO\nin\tO\nboth\tO\ngroups\tO\n,\tO\nin\tO\nthe\tO\nepileptic\tB-Disease\ngroup\tO\n,\tO\nthe\tO\ndecrease\tO\nin\tO\nVE\tO\nwas\tO\ndue\tO\nto\tO\na\tO\nsignificant\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nincrease\tO\nin\tO\nTE\tO\npeak\tO\nin\tO\nrelation\tO\nto\tO\nthat\tO\nof\tO\nthe\tO\ncontrol\tO\nanimals\tO\n.\tO\n\nThe\tO\nhypoventilation\tO\nmaneuver\tO\nled\tO\nto\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\narterial\tO\nPaco2\tO\n,\tO\nfollowed\tO\nby\tO\nan\tO\nincrease\tO\nin\tO\nVE\tO\n.\tO\n\nIn\tO\nthe\tO\nepileptic\tB-Disease\ngroup\tO\n,\tO\nthe\tO\nincrease\tO\nin\tO\nVE\tO\nwas\tO\nmediated\tO\nby\tO\na\tO\nsignificant\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\ndecrease\tO\nin\tO\nTE\tO\npeak\tO\ncompared\tO\nwith\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nSystemic\tO\napplication\tO\nof\tO\nKCN\tO\n,\tO\nto\tO\nevaluate\tO\nthe\tO\neffects\tO\nof\tO\nperipheral\tO\nchemoreception\tO\nactivation\tO\non\tO\nventilation\tO\n,\tO\nled\tO\nto\tO\na\tO\nsimilar\tO\nincrease\tO\nin\tO\nVE\tO\nfor\tO\nboth\tO\ngroups\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ndata\tO\nindicate\tO\nthat\tO\npilocarpine\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\nhave\tO\nan\tO\naltered\tO\nability\tO\nto\tO\nreact\tO\nto\tO\n(\tO\nor\tO\ncompensate\tO\nfor\tO\n)\tO\nblood\tO\ngas\tO\nchanges\tO\nwith\tO\nchanges\tO\nin\tO\nventilation\tO\nand\tO\nsuggest\tO\nthat\tO\nit\tO\nis\tO\ncentrally\tO\ndetermined\tO\n.\tO\n\nWe\tO\nspeculate\tO\non\tO\nthe\tO\npossible\tO\nrelation\tO\nof\tO\nthe\tO\ncurrent\tO\nfindings\tO\non\tO\ntreating\tO\ndifferent\tO\nepilepsy\tB-Disease\n-\tO\nassociated\tO\nconditions\tO\n.\tO\n\nFatal\tO\nmyeloencephalopathy\tB-Disease\ndue\tO\nto\tO\nintrathecal\tO\nvincristine\tB-Chemical\nadministration\tO\n.\tO\n\nVincristine\tB-Chemical\nwas\tO\naccidentally\tO\ngiven\tO\nintrathecally\tO\nto\tO\na\tO\nchild\tO\nwith\tO\nleukaemia\tB-Disease\n,\tO\nproducing\tO\nsensory\tB-Disease\nand\tI-Disease\nmotor\tI-Disease\ndysfunction\tI-Disease\nfollowed\tO\nby\tO\nencephalopathy\tB-Disease\nand\tO\ndeath\tO\n.\tO\n\nSeparate\tO\ntimes\tO\nfor\tO\nadministering\tO\nvincristine\tB-Chemical\nand\tO\nintrathecal\tO\ntherapy\tO\nis\tO\nrecommended\tO\n.\tO\n\nProgesterone\tB-Chemical\npotentiation\tO\nof\tO\nbupivacaine\tB-Chemical\narrhythmogenicity\tO\nin\tO\npentobarbital\tB-Chemical\n-\tO\nanesthetized\tO\nrats\tO\nand\tO\nbeating\tO\nrat\tO\nheart\tO\ncell\tO\ncultures\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nprogesterone\tB-Chemical\ntreatment\tO\non\tO\nbupivacaine\tB-Chemical\narrhythmogenicity\tO\nin\tO\nbeating\tO\nrat\tO\nheart\tO\nmyocyte\tO\ncultures\tO\nand\tO\non\tO\nanesthetized\tO\nrats\tO\nwere\tO\ndetermined\tO\n.\tO\n\nAfter\tO\ndetermining\tO\nthe\tO\nbupivacaine\tB-Chemical\nAD50\tO\n(\tO\nthe\tO\nconcentration\tO\nof\tO\nbupivacaine\tB-Chemical\nthat\tO\ncaused\tO\n50\tO\n%\tO\nof\tO\nall\tO\nbeating\tO\nrat\tO\nheart\tO\nmyocyte\tO\ncultures\tO\nto\tO\nbecome\tO\narrhythmic\tB-Disease\n)\tO\n,\tO\nwe\tO\ndetermined\tO\nthe\tO\neffect\tO\nof\tO\n1\tO\n-\tO\nhour\tO\nprogesterone\tB-Chemical\nHCl\tB-Chemical\nexposure\tO\non\tO\nmyocyte\tO\ncontractile\tO\nrhythm\tO\n.\tO\n\nEach\tO\nconcentration\tO\nof\tO\nprogesterone\tB-Chemical\n(\tO\n6\tO\n.\tO\n25\tO\n,\tO\n12\tO\n.\tO\n5\tO\n,\tO\n25\tO\n,\tO\nand\tO\n50\tO\nmicrograms\tO\n/\tO\nml\tO\n)\tO\ncaused\tO\na\tO\nsignificant\tO\nand\tO\nconcentration\tO\n-\tO\ndependent\tO\nreduction\tO\nin\tO\nthe\tO\nAD50\tO\nfor\tO\nbupivacaine\tB-Chemical\n.\tO\n\nEstradiol\tB-Chemical\ntreatment\tO\nalso\tO\nincreased\tO\nthe\tO\narrhythmogenicity\tO\nof\tO\nbupivacaine\tB-Chemical\nin\tO\nmyocyte\tO\ncultures\tO\n,\tO\nbut\tO\nwas\tO\nonly\tO\none\tO\nfourth\tO\nas\tO\npotent\tO\nas\tO\nprogesterone\tB-Chemical\n.\tO\n\nNeither\tO\nprogesterone\tB-Chemical\nnor\tO\nestradiol\tB-Chemical\neffects\tO\non\tO\nbupivacaine\tB-Chemical\narrhythmogenicity\tO\nwere\tO\npotentiated\tO\nby\tO\nepinephrine\tB-Chemical\n.\tO\n\nChronic\tO\nprogesterone\tB-Chemical\npretreatment\tO\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nfor\tO\n21\tO\ndays\tO\n)\tO\ncaused\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nbupivacaine\tB-Chemical\narrhythmogenicity\tO\nin\tO\nintact\tO\npentobarbital\tB-Chemical\n-\tO\nanesthetized\tO\nrats\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nthe\tO\ntime\tO\nto\tO\nonset\tO\nof\tO\narrhythmia\tB-Disease\nas\tO\ncompared\tO\nwith\tO\ncontrol\tO\nnonprogesterone\tO\n-\tO\ntreated\tO\nrats\tO\n(\tO\n6\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n3\tO\nvs\tO\n.\tO\n30\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n5\tO\nmin\tO\n,\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthis\tO\nstudy\tO\nindicate\tO\nthat\tO\nprogesterone\tB-Chemical\ncan\tO\npotentiate\tO\nbupivacaine\tB-Chemical\narrhythmogenicity\tO\nboth\tO\nin\tO\nvivo\tO\nand\tO\nin\tO\nvitro\tO\n.\tO\n\nPotentiation\tO\nof\tO\nbupivacaine\tB-Chemical\narrhythmia\tB-Disease\nin\tO\nmyocyte\tO\ncultures\tO\nsuggests\tO\nthat\tO\nthis\tO\neffect\tO\nis\tO\nat\tO\nleast\tO\npartly\tO\nmediated\tO\nat\tO\nthe\tO\nmyocyte\tO\nlevel\tO\n.\tO\n\nIncreased\tO\nserum\tO\nsoluble\tO\nFas\tO\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\ndue\tO\nto\tO\nparacetamol\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nBACKGROUND\tO\n/\tO\nAIMS\tO\n:\tO\nExperimental\tO\nstudies\tO\nhave\tO\nsuggested\tO\nthat\tO\napoptosis\tO\nvia\tO\nthe\tO\nFas\tO\n/\tO\nFas\tO\nLigand\tO\nsignaling\tO\nsystem\tO\nmay\tO\nplay\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthe\tO\nsoluble\tO\nform\tO\nof\tO\nFas\tO\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n.\tO\n\nMETHODOLOGY\tO\n:\tO\nSerum\tO\nlevels\tO\nof\tO\nsFas\tO\n(\tO\nsoluble\tO\nFas\tO\n)\tO\nwere\tO\nmeasured\tO\nby\tO\nELISA\tO\nin\tO\n24\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nand\tO\n10\tO\nnormal\tO\ncontrol\tO\nsubjects\tO\n.\tO\n\nSerum\tO\nlevels\tO\nof\tO\ntumor\tB-Disease\nnecrosis\tB-Disease\nfactor\tO\n-\tO\nalpha\tO\nand\tO\ninterferon\tO\n-\tO\ngamma\tO\nwere\tO\nalso\tO\ndetermined\tO\nby\tO\nELISA\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSerum\tO\nsFas\tO\nwas\tO\nsignificantly\tO\nincreased\tO\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n(\tO\nmedian\tO\n,\tO\n26\tO\n.\tO\n8\tO\nU\tO\n/\tO\nmL\tO\n;\tO\nrange\tO\n,\tO\n6\tO\n.\tO\n9\tO\n-\tO\n52\tO\n.\tO\n7\tO\nU\tO\n/\tO\nmL\tO\n)\tO\ncompared\tO\nto\tO\nthe\tO\nnormal\tO\ncontrols\tO\n(\tO\nmedian\tO\n,\tO\n8\tO\n.\tO\n6\tO\nU\tO\n/\tO\nmL\tO\n;\tO\nrange\tO\n,\tO\n6\tO\n.\tO\n5\tO\n-\tO\n12\tO\n.\tO\n0\tO\nU\tO\n/\tO\nmL\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nLevels\tO\nwere\tO\nsignificantly\tO\ngreater\tO\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\ndue\tO\nto\tO\nparacetamol\tB-Chemical\noverdose\tB-Disease\n(\tO\nmedian\tO\n,\tO\n28\tO\n.\tO\n7\tO\nU\tO\n/\tO\nmL\tO\n;\tO\nrange\tO\n,\tO\n12\tO\n.\tO\n8\tO\n-\tO\n52\tO\n.\tO\n7\tO\nU\tO\n/\tO\nmL\tO\n,\tO\nn\tO\n=\tO\n17\tO\n)\tO\nthan\tO\nthose\tO\ndue\tO\nto\tO\nnon\tO\n-\tO\nA\tO\nto\tO\nE\tO\nhepatitis\tB-Disease\n(\tO\nmedian\tO\n,\tO\n12\tO\n.\tO\n5\tO\nU\tO\n/\tO\nmL\tO\n;\tO\nrange\tO\n,\tO\n6\tO\n.\tO\n9\tO\n-\tO\n46\tO\n.\tO\n0\tO\nU\tO\n/\tO\nmL\tO\n,\tO\nn\tO\n=\tO\n7\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nrelationship\tO\nof\tO\nsFas\tO\nto\tO\neventual\tO\noutcome\tO\nin\tO\nthe\tO\npatients\tO\n.\tO\n\nA\tO\nsignificant\tO\ncorrelation\tO\nwas\tO\nobserved\tO\nbetween\tO\nserum\tO\nsFas\tO\nlevels\tO\nand\tO\naspartate\tB-Chemical\naminotransferase\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n613\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nincreased\tO\nconcentration\tO\nof\tO\nsFas\tO\nin\tO\nserum\tO\nof\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nmay\tO\nreflect\tO\nactivation\tO\nof\tO\nFas\tO\n-\tO\nmediated\tO\napoptosis\tO\nin\tO\nthe\tO\nliver\tO\nand\tO\nthis\tO\ntogether\tO\nwith\tO\nincreased\tO\ntumor\tB-Disease\nnecrosis\tB-Disease\nfactor\tO\n-\tO\nalpha\tO\nmay\tO\nbe\tO\nan\tO\nimportant\tO\nfactor\tO\nin\tO\nliver\tO\ncell\tO\nloss\tO\n.\tO\n\nBilateral\tO\nsubthalamic\tO\nnucleus\tO\nstimulation\tO\nfor\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nHigh\tO\nfrequency\tO\nstimulation\tO\nof\tO\nthe\tO\nsubthalamic\tO\nnucleus\tO\n(\tO\nSTN\tO\n)\tO\nis\tO\nknown\tO\nto\tO\nameliorate\tO\nthe\tO\nsigns\tO\nand\tO\nsymptoms\tO\nof\tO\nadvanced\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nAIM\tO\n:\tO\nWe\tO\nstudied\tO\nthe\tO\neffect\tO\nof\tO\nhigh\tO\nfrequency\tO\nSTN\tO\nstimulation\tO\nin\tO\n23\tO\npatients\tO\n.\tO\n\nMETHOD\tO\n:\tO\nTwenty\tO\n-\tO\nthree\tO\npatients\tO\nsuffering\tO\nfrom\tO\nsevere\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nStages\tO\nIII\tO\n-\tO\nV\tO\non\tO\nHoehn\tO\nand\tO\nYahr\tO\nscale\tO\n)\tO\nand\tO\n,\tO\nparticularly\tO\nbradykinesia\tB-Disease\n,\tO\nrigidity\tB-Disease\n,\tO\nand\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nunderwent\tO\nbilateral\tO\nimplantation\tO\nof\tO\nelectrodes\tO\nin\tO\nthe\tO\nSTN\tO\n.\tO\n\nPreoperative\tO\nand\tO\npostoperative\tO\nassessments\tO\nof\tO\nthese\tO\npatients\tO\nat\tO\n1\tO\n,\tO\n3\tO\n,\tO\n6\tO\nand\tO\n12\tO\nmonths\tO\nfollow\tO\n-\tO\nup\tO\n,\tO\nin\tO\n\"\tO\non\tO\n\"\tO\nand\tO\n\"\tO\noff\tO\n\"\tO\ndrug\tO\nconditions\tO\n,\tO\nwas\tO\ncarried\tO\nout\tO\nusing\tO\nUnified\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nRating\tO\nScale\tO\n,\tO\nHoehn\tO\nand\tO\nYahr\tO\nstaging\tO\n,\tO\nEngland\tO\nactivities\tO\nof\tO\ndaily\tO\nliving\tO\nscore\tO\nand\tO\nvideo\tO\nrecordings\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAfter\tO\none\tO\nyear\tO\nof\tO\nelectrical\tO\nstimulation\tO\nof\tO\nthe\tO\nSTN\tO\n,\tO\nthe\tO\npatients\tO\n'\tO\nscores\tO\nfor\tO\nactivities\tO\nof\tO\ndaily\tO\nliving\tO\nand\tO\nmotor\tO\nexamination\tO\nscores\tO\n(\tO\nUnified\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nRating\tO\nScale\tO\nparts\tO\nII\tO\nand\tO\nIII\tO\n)\tO\noff\tO\nmedication\tO\nimproved\tO\nby\tO\n62\tO\n%\tO\nand\tO\n61\tO\n%\tO\nrespectively\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n0005\tO\n)\tO\n.\tO\n\nThe\tO\nsubscores\tO\nfor\tO\nthe\tO\nakinesia\tB-Disease\n,\tO\nrigidity\tB-Disease\n,\tO\ntremor\tB-Disease\nand\tO\ngait\tO\nalso\tO\nimproved\tO\n.\tO\n\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n0005\tO\n)\tO\n.\tO\n\nThe\tO\naverage\tO\nlevodopa\tB-Chemical\ndose\tO\ndecreased\tO\nfrom\tO\n813\tO\nmg\tO\nto\tO\n359\tO\nmg\tO\n.\tO\n\nThe\tO\ncognitive\tO\nfunctions\tO\nremained\tO\nunchanged\tO\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\ndevice\tO\n-\tO\nrelated\tO\ncomplications\tO\nand\tO\ntwo\tO\npatients\tO\nexperienced\tO\nabnormal\tO\nweight\tO\ngain\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nBilateral\tO\nsubthalamic\tO\nnucleus\tO\nstimulation\tO\nis\tO\nan\tO\neffective\tO\ntreatment\tO\nfor\tO\nadvanced\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nIt\tO\nreduces\tO\nthe\tO\nseverity\tO\nof\tO\n\"\tO\noff\tO\n\"\tO\nphase\tO\nsymptoms\tO\n,\tO\nimproves\tO\nthe\tO\naxial\tO\nsymptoms\tO\nand\tO\nreduces\tO\nlevodopa\tB-Chemical\nrequirements\tO\n.\tO\n\nThe\tO\nreduction\tO\nin\tO\nthe\tO\nlevodopa\tB-Chemical\ndose\tO\nis\tO\nuseful\tO\nin\tO\ncontrolling\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\ndyskinesias\tI-Disease\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\noccurring\tO\nduring\tO\nintravenous\tO\ndesferrioxamine\tB-Chemical\ntherapy\tO\n:\tO\nrecovery\tO\nafter\tO\nhaemodialysis\tO\n.\tO\n\nA\tO\npatient\tO\nwith\tO\ntransfusion\tO\n-\tO\ndependent\tO\nthalassemia\tB-Disease\nwas\tO\nundergoing\tO\nhome\tO\nintravenous\tO\ndesferrioxamine\tB-Chemical\n(\tO\nDFX\tB-Chemical\n)\tO\ntreatment\tO\nby\tO\nmeans\tO\nof\tO\na\tO\ntotally\tO\nimplanted\tO\nsystem\tO\nbecause\tO\nof\tO\nhis\tO\npoor\tO\ncompliance\tO\nwith\tO\nthe\tO\nnightly\tO\nsubcutaneous\tO\ntherapy\tO\n.\tO\n\nDue\tO\nto\tO\nan\tO\naccidental\tO\nmalfunctioning\tO\nof\tO\nthe\tO\ninfusion\tO\npump\tO\n,\tO\nthe\tO\npatient\tO\nwas\tO\ninadvertently\tO\nadministered\tO\na\tO\ntoxic\tO\ndosage\tO\nof\tO\nthe\tO\ndrug\tO\nwhich\tO\ncaused\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\n.\tO\n\nGiven\tO\nthe\tO\nprogressive\tO\ndeterioration\tO\nof\tO\nthe\tO\nsymptoms\tO\nand\tO\nof\tO\nthe\tO\nlaboratory\tO\nvalues\tO\n,\tO\ndespite\tO\nadequate\tO\nmedical\tO\ntreatment\tO\n,\tO\na\tO\ndecision\tO\nwas\tO\nmade\tO\nto\tO\nintroduce\tO\nhaemodialytical\tO\ntherapy\tO\nin\tO\norder\tO\nto\tO\nremove\tO\nthe\tO\ndrug\tO\nand\tO\ntherapy\tO\nreduce\tO\nthe\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nFrom\tO\nthe\tO\nresults\tO\nobtained\tO\n,\tO\nhaemodialysis\tO\ncan\tO\ntherefore\tO\nbe\tO\nsuggested\tO\nas\tO\na\tO\nuseful\tO\ntherapy\tO\nin\tO\nrare\tO\ncases\tO\nof\tO\nprogressive\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\ncaused\tO\nby\tO\ndesferrioxamine\tB-Chemical\n.\tO\n\nOcular\tO\nmotility\tO\nchanges\tO\nafter\tO\nsubtenon\tO\ncarboplatin\tB-Chemical\nchemotherapy\tO\nfor\tO\nretinoblastoma\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nFocal\tO\nsubtenon\tO\ncarboplatin\tB-Chemical\ninjections\tO\nhave\tO\nrecently\tO\nbeen\tO\nused\tO\nas\tO\na\tO\npresumably\tO\ntoxicity\tB-Disease\n-\tO\nfree\tO\nadjunct\tO\nto\tO\nsystemic\tO\nchemotherapy\tO\nfor\tO\nintraocular\tO\nretinoblastoma\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\nour\tO\nclinical\tO\nexperience\tO\nwith\tO\nabnormal\tB-Disease\nocular\tI-Disease\nmotility\tI-Disease\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nsubtenon\tO\ncarboplatin\tB-Chemical\nchemotherapy\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nnoted\tO\nabnormal\tB-Disease\nocular\tI-Disease\nmotility\tI-Disease\nin\tO\n10\tO\nconsecutive\tO\npatients\tO\nwith\tO\nretinoblastoma\tB-Disease\nwho\tO\nhad\tO\nreceived\tO\nsubtenon\tO\ncarboplatin\tB-Chemical\n.\tO\n\nDuring\tO\nocular\tO\nmanipulation\tO\nunder\tO\ngeneral\tO\nanesthesia\tO\n,\tO\nwe\tO\nassessed\tO\ntheir\tO\neyes\tO\nby\tO\nforced\tO\nduction\tO\ntesting\tO\n,\tO\ncomparing\tO\nocular\tO\nmotility\tO\nafter\tO\ntumor\tB-Disease\ncontrol\tO\nwith\tO\nocular\tO\nmotility\tO\nat\tO\ndiagnosis\tO\n.\tO\n\nEyes\tO\nsubsequently\tO\nenucleated\tO\nbecause\tO\nof\tO\ntreatment\tO\nfailure\tO\n(\tO\nn\tO\n=\tO\n4\tO\n)\tO\nwere\tO\nexamined\tO\nhistologically\tO\n.\tO\n\nRESULTS\tO\n:\tO\nLimitation\tO\nof\tO\nocular\tO\nmotility\tO\nwas\tO\ndetected\tO\nin\tO\nall\tO\n12\tO\neyes\tO\nof\tO\n10\tO\npatients\tO\ntreated\tO\nfor\tO\nintraocular\tO\nretinoblastoma\tB-Disease\nwith\tO\n1\tO\nto\tO\n6\tO\ninjections\tO\nof\tO\nsubtenon\tO\ncarboplatin\tB-Chemical\nas\tO\npart\tO\nof\tO\nmultimodality\tO\ntherapy\tO\n.\tO\n\nHistopathological\tO\nexamination\tO\nrevealed\tO\nmany\tO\nlipophages\tO\nin\tO\nthe\tO\nperiorbital\tO\nfat\tO\nsurrounding\tO\nthe\tO\noptic\tO\nnerve\tO\nin\tO\n1\tO\neye\tO\n,\tO\nindicative\tO\nof\tO\nphagocytosis\tO\nof\tO\npreviously\tO\nexisting\tO\nfat\tO\ncells\tO\nand\tO\nsuggesting\tO\nprior\tO\nfat\tO\nnecrosis\tB-Disease\n.\tO\n\nThe\tO\nenucleations\tO\nwere\tO\ntechnically\tO\ndifficult\tO\nand\tO\nhazardous\tO\nfor\tO\nglobe\tO\nrupture\tB-Disease\nbecause\tO\nof\tO\nextensive\tO\norbital\tO\nsoft\tO\ntissue\tO\nadhesions\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSubtenon\tO\ncarboplatin\tB-Chemical\nchemotherapy\tO\nis\tO\nassociated\tO\nwith\tO\nsignificant\tO\nfibrosis\tB-Disease\nof\tO\norbital\tO\nsoft\tO\ntissues\tO\n,\tO\nleading\tO\nto\tO\nmechanical\tO\nrestriction\tO\nof\tO\neye\tO\nmovements\tO\nand\tO\nmaking\tO\nsubsequent\tO\nenucleation\tO\ndifficult\tO\n.\tO\n\nSubtenon\tO\ncarboplatin\tB-Chemical\nis\tO\nnot\tO\nfree\tO\nof\tO\ntoxicity\tB-Disease\n,\tO\nand\tO\nits\tO\nuse\tO\nis\tO\nbest\tO\nrestricted\tO\nto\tO\nspecific\tO\nindications\tO\n.\tO\n\nEthambutol\tB-Chemical\nand\tO\noptic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\ndemonstrate\tO\nthe\tO\nassociation\tO\nbetween\tO\nethambutol\tB-Chemical\nand\tO\noptic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nThirteen\tO\npatients\tO\nwho\tO\ndeveloped\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nafter\tO\nbeing\tO\ntreated\tO\nwith\tO\nethambutol\tB-Chemical\nfor\tO\ntuberculosis\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nlung\tI-Disease\nor\tI-Disease\nlymph\tI-Disease\nnode\tI-Disease\nat\tO\nSiriraj\tO\nHospital\tO\nbetween\tO\n1997\tO\nand\tO\n2001\tO\nwere\tO\nretrospectively\tO\nreviewed\tO\n.\tO\n\nThe\tO\nclinical\tO\ncharacteristics\tO\nand\tO\ninitial\tO\nand\tO\nfinal\tO\nvisual\tO\nacuity\tO\nwere\tO\nanalyzed\tO\nto\tO\ndetermine\tO\nvisual\tO\noutcome\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\npatients\tO\nhad\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nbetween\tO\n1\tO\nto\tO\n6\tO\nmonths\tO\n(\tO\nmean\tO\n=\tO\n2\tO\n.\tO\n9\tO\nmonths\tO\n)\tO\nafter\tO\nstarting\tO\nethambutol\tB-Chemical\ntherapy\tO\nat\tO\na\tO\ndosage\tO\nranging\tO\nfrom\tO\n13\tO\nto\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\nmean\tO\n=\tO\n17\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n)\tO\n.\tO\n\nSeven\tO\n(\tO\n54\tO\n%\tO\n)\tO\nof\tO\nthe\tO\n13\tO\npatients\tO\nexperienced\tO\nvisual\tO\nrecovery\tO\nafter\tO\nstopping\tO\nthe\tO\ndrug\tO\n.\tO\n\nOf\tO\n6\tO\npatients\tO\nwith\tO\nirreversible\tO\nvisual\tB-Disease\nimpairment\tI-Disease\n,\tO\n4\tO\npatients\tO\nhad\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\n,\tO\nglaucoma\tB-Disease\nand\tO\na\tO\nhistory\tO\nof\tO\nheavy\tO\nsmoking\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nEarly\tO\nrecognition\tO\nof\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nshould\tO\nbe\tO\nconsidered\tO\nin\tO\npatients\tO\nwith\tO\nethambutol\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\nlow\tO\ndose\tO\nand\tO\nprompt\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nis\tO\nrecommended\tO\nparticularly\tO\nin\tO\nindividuals\tO\nwith\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\n,\tO\nglaucoma\tB-Disease\nor\tO\nwho\tO\nare\tO\nheavy\tO\nsmokers\tO\n.\tO\n\nTreatment\tO\nof\tO\ncompensatory\tO\ngustatory\tB-Disease\nhyperhidrosis\tI-Disease\nwith\tO\ntopical\tO\nglycopyrrolate\tB-Chemical\n.\tO\n\nGustatory\tB-Disease\nhyperhidrosis\tI-Disease\nis\tO\nfacial\tO\nsweating\tB-Disease\nusually\tO\nassociated\tO\nwith\tO\nthe\tO\neating\tO\nof\tO\nhot\tO\nspicy\tO\nfood\tO\nor\tO\neven\tO\nsmelling\tO\nthis\tO\nfood\tO\n.\tO\n\nCurrent\tO\noptions\tO\nof\tO\ntreatment\tO\ninclude\tO\noral\tO\nanticholinergic\tO\ndrugs\tO\n,\tO\nthe\tO\ntopical\tO\napplication\tO\nof\tO\nanticholinergics\tO\nor\tO\naluminum\tB-Chemical\nchloride\tI-Chemical\n,\tO\nand\tO\nthe\tO\ninjection\tO\nof\tO\nbotulinum\tO\ntoxin\tO\n.\tO\n\nThirteen\tO\npatients\tO\nhave\tO\nbeen\tO\ntreated\tO\nto\tO\ndate\tO\nwith\tO\n1\tO\n.\tO\n5\tO\n%\tO\nor\tO\n2\tO\n%\tO\ntopical\tO\nglycopyrrolate\tB-Chemical\n.\tO\n\nAll\tO\npatients\tO\nhad\tO\ngustatory\tB-Disease\nhyperhidrosis\tI-Disease\n,\tO\nwhich\tO\ninterfered\tO\nwith\tO\ntheir\tO\nsocial\tO\nactivities\tO\n,\tO\nafter\tO\ntransthroacic\tO\nendoscopic\tO\nsympathectomy\tO\n,\tO\nand\tO\nwhich\tO\nwas\tO\nassociated\tO\nwith\tO\ncompensatory\tO\nfocal\tO\nhyperhidrosis\tB-Disease\n.\tO\n\nAfter\tO\napplying\tO\ntopical\tO\nglycopyrrolate\tB-Chemical\n,\tO\nthe\tO\nsubjective\tO\neffect\tO\nwas\tO\nexcellent\tO\n(\tO\nno\tO\nsweating\tB-Disease\nafter\tO\neating\tO\nhot\tO\nspicy\tO\nfood\tO\n)\tO\nin\tO\n10\tO\npatients\tO\n(\tO\n77\tO\n%\tO\n)\tO\n,\tO\nand\tO\nfair\tO\n(\tO\nclearly\tO\nreduced\tO\nsweating\tB-Disease\n)\tO\nin\tO\n3\tO\npatients\tO\n(\tO\n23\tO\n%\tO\n)\tO\n.\tO\n\nAll\tO\nhad\tO\nreported\tO\nincidents\tO\nof\tO\nbeing\tO\nvery\tO\nembarrassed\tO\nwhilst\tO\neating\tO\nhot\tO\nspicy\tO\nfoods\tO\n.\tO\n\nAdverse\tO\neffects\tO\nincluded\tO\na\tO\nmildly\tO\ndry\tB-Disease\nmouth\tI-Disease\nand\tO\na\tO\nsore\tB-Disease\nthroat\tI-Disease\nin\tO\n2\tO\npatients\tO\n(\tO\n2\tO\n%\tO\nglycopyrrolate\tB-Chemical\n)\tO\n,\tO\na\tO\nlight\tO\nheadache\tB-Disease\nin\tO\n1\tO\npatient\tO\n(\tO\n1\tO\n.\tO\n5\tO\n%\tO\nglycopyrrolate\tB-Chemical\n)\tO\n.\tO\n\nThe\tO\ntopical\tO\napplication\tO\nof\tO\na\tO\nglycopyrrolate\tB-Chemical\npad\tO\nappeared\tO\nto\tO\nbe\tO\nsafe\tO\n,\tO\nefficacious\tO\n,\tO\nwell\tO\ntolerated\tO\n,\tO\nand\tO\na\tO\nconvenient\tO\nmethod\tO\nof\tO\ntreatment\tO\nfor\tO\nmoderate\tO\nto\tO\nsevere\tO\nsymptoms\tO\nof\tO\ngustatory\tB-Disease\nhyperhidrosis\tI-Disease\nin\tO\npost\tO\ntransthoracic\tO\nendoscopic\tO\nsympathectomy\tO\nor\tO\nsympathicotomy\tO\npatients\tO\n,\tO\nwith\tO\nfew\tO\nside\tO\neffects\tO\n.\tO\n\nNeuroleptic\tB-Chemical\n-\tO\nassociated\tO\nhyperprolactinemia\tB-Disease\n.\tO\n\nCan\tO\nit\tO\nbe\tO\ntreated\tO\nwith\tO\nbromocriptine\tB-Chemical\n?\tO\n\nSix\tO\nstable\tO\npsychiatric\tO\noutpatients\tO\nwith\tO\nhyperprolactinemia\tB-Disease\nand\tO\namenorrhea\tB-Disease\n/\tO\noligomenorrhea\tB-Disease\nassociated\tO\nwith\tO\ntheir\tO\nneuroleptic\tB-Chemical\nmedications\tI-Chemical\nwere\tO\ntreated\tO\nwith\tO\nbromocriptine\tB-Chemical\n.\tO\n\nDaily\tO\ndosages\tO\nof\tO\n5\tO\n-\tO\n10\tO\nmg\tO\ncorrected\tO\nthe\tO\nhyperprolactinemia\tB-Disease\nand\tO\nrestored\tO\nmenstruation\tO\nin\tO\nfour\tO\nof\tO\nthe\tO\nsix\tO\npatients\tO\n.\tO\n\nOne\tO\nwoman\tO\n,\tO\nhowever\tO\n,\tO\ndeveloped\tO\nworsened\tO\npsychiatric\tB-Disease\nsymptoms\tI-Disease\nwhile\tO\ntaking\tO\nbromocriptine\tB-Chemical\n,\tO\nand\tO\nit\tO\nwas\tO\ndiscontinued\tO\n.\tO\n\nThus\tO\n,\tO\nthree\tO\nof\tO\nsix\tO\npatients\tO\nhad\tO\ntheir\tO\nmenstrual\tO\nirregularity\tO\nsuccessfully\tO\ncorrected\tO\nwith\tO\nbromocriptine\tB-Chemical\n.\tO\n\nThis\tO\nsuggests\tO\nthat\tO\nbromocriptine\tB-Chemical\nshould\tO\nbe\tO\nfurther\tO\nevaluated\tO\nas\tO\npotential\tO\ntherapy\tO\nfor\tO\nneuroleptic\tB-Chemical\n-\tO\nassociated\tO\nhyperprolactinemia\tB-Disease\nand\tO\namenorrhea\tB-Disease\n/\tO\ngalactorrhea\tB-Disease\n.\tO\n\nEthacrynic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nand\tO\nbrain\tO\nneurotransmitters\tO\nin\tO\nmice\tO\n.\tO\n\nIntracerebroventricular\tO\ninjection\tO\nof\tO\nethacrynic\tB-Chemical\nacid\tI-Chemical\n(\tO\n50\tO\n%\tO\nconvulsive\tB-Disease\ndose\tO\n;\tO\n50\tO\nmicrograms\tO\n/\tO\nmouse\tO\n)\tO\naccelerated\tO\nthe\tO\nsynthesis\tO\n/\tO\nturnover\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptamine\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n)\tO\nbut\tO\nsuppressed\tO\nthe\tO\nsynthesis\tO\nof\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\nand\tO\nacetylcholine\tB-Chemical\nin\tO\nmouse\tO\nbrain\tO\n.\tO\n\nThese\tO\neffects\tO\nwere\tO\ncompletely\tO\nantagonized\tO\nby\tO\npretreatment\tO\nwith\tO\na\tO\nglutamate\tB-Chemical\n/\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\nantagonist\tO\n,\tO\naminophosphonovaleric\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nIn\tO\nethacrynic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n,\tO\nthese\tO\nneurotransmitter\tO\nsystems\tO\nmay\tO\nbe\tO\ndifferentially\tO\nmodulated\tO\n,\tO\nprobably\tO\nthrough\tO\nactivation\tO\nof\tO\nglutaminergic\tO\nneurons\tO\nin\tO\nthe\tO\nbrain\tO\n.\tO\n\nPharmacology\tO\nof\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacidA\tI-Chemical\nreceptor\tO\ncomplex\tO\nafter\tO\nthe\tO\nin\tO\nvivo\tO\nadministration\tO\nof\tO\nthe\tO\nanxioselective\tO\nand\tO\nanticonvulsant\tO\nbeta\tB-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\nderivative\tO\nabecarnil\tB-Chemical\n.\tO\n\nIn\tO\nrodents\tO\n,\tO\nthe\tO\neffect\tO\nof\tO\nthe\tO\nbeta\tB-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\nderivative\tO\nisopropyl\tB-Chemical\n-\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\nbenzyloxy\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethoxymethyl\tI-Chemical\n-\tI-Chemical\nbeta\tI-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\ncarboxylate\tI-Chemical\n(\tO\nabecarrnil\tB-Chemical\n)\tO\n,\tO\na\tO\nnew\tO\nligand\tO\nfor\tO\nbenzodiazepine\tB-Chemical\nreceptors\tO\npossessing\tO\nanxiolytic\tO\nand\tO\nanticonvulsant\tO\nproperties\tO\n,\tO\nwas\tO\nevaluated\tO\non\tO\nthe\tO\nfunction\tO\nof\tO\ncentral\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n(\tO\nGABA\tB-Chemical\n)\tO\nA\tO\nreceptor\tO\ncomplex\tO\n,\tO\nboth\tO\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\n.\tO\n\nAdded\tO\nin\tO\nvitro\tO\nto\tO\nrat\tO\ncortical\tO\nmembrane\tO\npreparation\tO\n,\tO\nabecarnil\tB-Chemical\nincreased\tO\n[\tO\n3H\tO\n]\tO\nGABA\tB-Chemical\nbinding\tO\n,\tO\nenhanced\tO\nmuscimol\tB-Chemical\n-\tO\nstimulated\tO\n36Cl\tO\n-\tO\nuptake\tO\nand\tO\nreduced\tO\nthe\tO\nbinding\tO\nof\tO\nt\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n35S\tI-Chemical\n]\tI-Chemical\nbutylbicyclophosphorothionate\tI-Chemical\n(\tO\n[\tB-Chemical\n35S\tI-Chemical\n]\tI-Chemical\nTBPS\tI-Chemical\n)\tO\n.\tO\n\nThese\tO\neffects\tO\nwere\tO\nsimilar\tO\nto\tO\nthose\tO\ninduced\tO\nby\tO\ndiazepam\tB-Chemical\n,\tO\nwhereas\tO\nthe\tO\npartial\tO\nagonist\tO\nRo\tB-Chemical\n16\tI-Chemical\n-\tI-Chemical\n6028\tI-Chemical\n(\tO\ntert\tB-Chemical\n-\tI-Chemical\nbutyl\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\nS\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n8\tI-Chemical\n-\tI-Chemical\nbromo\tI-Chemical\n-\tI-Chemical\n11\tI-Chemical\n,\tI-Chemical\n12\tI-Chemical\n,\tI-Chemical\n13\tI-Chemical\n,\tI-Chemical\n13a\tI-Chemical\n-\tI-Chemical\ntetrahydro\tI-Chemical\n-\tI-Chemical\n9\tI-Chemical\n-\tI-Chemical\noxo\tI-Chemical\n-\tI-Chemical\n9H\tI-Chemical\n-\tI-Chemical\nimidazo\tI-Chemical\n[\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\na\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\npyrrolo\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nc\tI-Chemical\n]\tI-Chemical\n[\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n]\tI-Chemical\nbenzodiazepine\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\ncarboxylate\tI-Chemical\n)\tO\nshowed\tO\nvery\tO\nweak\tO\nefficacy\tO\nin\tO\nthese\tO\nbiochemical\tO\ntests\tO\n.\tO\n\nAfter\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tO\nto\tO\nrats\tO\n,\tO\nabecarnil\tB-Chemical\nand\tO\ndiazepam\tB-Chemical\ndecreased\tO\nin\tO\na\tO\ntime\tO\n-\tO\ndependent\tO\nand\tO\ndose\tO\n-\tO\nrelated\tO\n(\tO\n0\tO\n.\tO\n25\tO\n-\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nmanner\tO\n[\tB-Chemical\n35S\tI-Chemical\n]\tI-Chemical\nTBPS\tI-Chemical\nbinding\tO\nmeasured\tO\nex\tO\nvivo\tO\nin\tO\nthe\tO\ncerebral\tO\ncortex\tO\n.\tO\n\nMoreover\tO\n,\tO\nboth\tO\ndrugs\tO\nat\tO\nthe\tO\ndose\tO\nof\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nantagonized\tO\ncompletely\tO\nthe\tO\nconvulsant\tO\nactivity\tO\nand\tO\nthe\tO\nincrease\tO\nof\tO\n[\tB-Chemical\n35S\tI-Chemical\n]\tI-Chemical\nTBPS\tI-Chemical\nbinding\tO\ninduced\tO\nby\tO\nisoniazide\tB-Chemical\n(\tO\n350\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\nincrease\tO\nof\tO\n[\tB-Chemical\n35S\tI-Chemical\n]\tI-Chemical\nTBPS\tI-Chemical\nbinding\tO\ninduced\tO\nby\tO\nfoot\tO\n-\tO\nshock\tO\nstress\tO\n.\tO\n\nTo\tO\nbetter\tO\ncorrelate\tO\nthe\tO\nbiochemical\tO\nand\tO\nthe\tO\npharmacological\tO\neffects\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\naction\tO\nof\tO\nabecarnil\tB-Chemical\non\tO\n[\tB-Chemical\n35S\tI-Chemical\n]\tI-Chemical\nTBPS\tI-Chemical\nbinding\tO\n,\tO\nexploratory\tO\nmotility\tO\nand\tO\non\tO\nisoniazid\tB-Chemical\n-\tO\ninduced\tO\nbiochemical\tO\nand\tO\npharmacological\tO\neffects\tO\nin\tO\nmice\tO\n.\tO\n\nIn\tO\nthese\tO\nanimals\tO\n,\tO\nabecarnil\tB-Chemical\nproduced\tO\na\tO\nparalleled\tO\ndose\tO\n-\tO\ndependent\tO\n(\tO\n0\tO\n.\tO\n05\tO\n-\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nreduction\tO\nof\tO\nboth\tO\nmotor\tO\nbehavior\tO\nand\tO\ncortical\tO\n[\tO\n35S\tO\n]\tO\nTBPS\tO\nbinding\tO\n.\tO\n\nMoreover\tO\n,\tO\n0\tO\n.\tO\n05\tO\nmg\tO\n/\tO\nkg\tO\nof\tO\nthis\tO\nbeta\tB-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\nreduced\tO\nmarkedly\tO\nthe\tO\nincrease\tO\nof\tO\n[\tB-Chemical\n35S\tI-Chemical\n]\tI-Chemical\nTBPS\tI-Chemical\nbinding\tO\nand\tO\nthe\tO\nconvulsions\tB-Disease\ninduced\tO\nby\tO\nisoniazid\tB-Chemical\n(\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nRecurrent\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\na\tO\npostpartum\tO\npatient\tO\nreceiving\tO\nbromocriptine\tB-Chemical\n.\tO\n\nMyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\npuerperium\tO\nis\tO\ninfrequently\tO\nreported\tO\n.\tO\n\nSpasm\tB-Disease\n,\tO\ncoronary\tO\ndissection\tO\n,\tO\nor\tO\natheromatous\tO\netiology\tO\nhas\tO\nbeen\tO\ndescribed\tO\n.\tO\n\nBromocriptine\tB-Chemical\nhas\tO\nbeen\tO\nimplicated\tO\nin\tO\nseveral\tO\nprevious\tO\ncase\tO\nreports\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nthe\tO\npuerperium\tO\n.\tO\n\nOur\tO\ncase\tO\n(\tO\nincluding\tO\nan\tO\ninadvertent\tO\nrechallenge\tO\n)\tO\nsuggests\tO\nsuch\tO\na\tO\nrelationship\tO\n.\tO\n\nAlthough\tO\ngenerally\tO\nregarded\tO\nas\tO\n\"\tO\nsafe\tO\n,\tO\n\"\tO\npossible\tO\nserious\tO\ncardiac\tO\neffects\tO\nof\tO\nbromocriptine\tB-Chemical\nshould\tO\nbe\tO\nacknowledged\tO\n.\tO\n\nAsterixis\tB-Disease\ninduced\tO\nby\tO\ncarbamazepine\tB-Chemical\ntherapy\tO\n.\tO\n\nThere\tO\nare\tO\nvery\tO\nfew\tO\nreports\tO\nabout\tO\nasterixis\tB-Disease\nas\tO\na\tO\nside\tO\neffect\tO\nof\tO\ntreatment\tO\nwith\tO\npsychopharmacologic\tO\nagents\tO\n.\tO\n\nIn\tO\nthis\tO\nreport\tO\nwe\tO\npresent\tO\nfour\tO\npatients\tO\ntreated\tO\nwith\tO\na\tO\ncombination\tO\nof\tO\ndifferent\tO\npsychotropic\tO\ndrugs\tO\n,\tO\nin\tO\nwhom\tO\nasterixis\tB-Disease\nwas\tO\ntriggered\tO\neither\tO\nby\tO\nadding\tO\ncarbamazepine\tB-Chemical\n(\tO\nCBZ\tB-Chemical\n)\tO\nto\tO\na\tO\ntreatment\tO\nregimen\tO\n,\tO\nor\tO\nby\tO\nincreasing\tO\nits\tO\ndosage\tO\n.\tO\n\nNeither\tO\ndosage\tO\nnor\tO\nserum\tO\nlevels\tO\nof\tO\nCBZ\tB-Chemical\nwere\tO\nin\tO\na\tO\nhigher\tO\nrange\tO\n.\tO\n\nWe\tO\nconsider\tO\nasterixis\tB-Disease\nto\tO\nbe\tO\nan\tO\neasily\tO\noverlooked\tO\nsign\tO\nof\tO\nneurotoxicity\tB-Disease\n,\tO\nwhich\tO\nmay\tO\noccur\tO\neven\tO\nat\tO\nlow\tO\nor\tO\nmoderate\tO\ndosage\tO\nlevels\tO\n,\tO\nif\tO\ncertain\tO\ndrugs\tO\nas\tO\nlithium\tB-Chemical\nor\tO\nclozapine\tB-Chemical\nare\tO\nused\tO\nin\tO\ncombination\tO\nwith\tO\nCBZ\tB-Chemical\n.\tO\n\nPharmacodynamics\tO\nof\tO\nthe\tO\nhypotensive\tB-Disease\neffect\tO\nof\tO\nlevodopa\tB-Chemical\nin\tO\nparkinsonian\tB-Disease\npatients\tO\n.\tO\n\nBlood\tO\npressure\tO\neffects\tO\nof\tO\ni\tO\n.\tO\nv\tO\n.\tO\nlevodopa\tB-Chemical\nwere\tO\nexamined\tO\nin\tO\nparkinsonian\tB-Disease\npatients\tO\nwith\tO\nstable\tO\nand\tO\nfluctuating\tO\nresponses\tO\nto\tO\nlevodopa\tB-Chemical\n.\tO\n\nThe\tO\nmagnitude\tO\nof\tO\nthe\tO\nhypotensive\tB-Disease\neffect\tO\nof\tO\nlevodopa\tB-Chemical\nwas\tO\nconcentration\tO\ndependent\tO\nand\tO\nwas\tO\nfit\tO\nto\tO\nan\tO\nEmax\tO\nmodel\tO\nin\tO\nfluctuating\tO\nresponders\tO\n.\tO\n\nStable\tO\nresponders\tO\ndemonstrated\tO\na\tO\nsmall\tO\nhypotensive\tB-Disease\nresponse\tO\n.\tO\n\nBaseline\tO\nblood\tO\npressures\tO\nwere\tO\nhigher\tO\nin\tO\nfluctuating\tO\npatients\tO\n;\tO\na\tO\nhigher\tO\nbaseline\tO\nblood\tO\npressure\tO\ncorrelated\tO\nwith\tO\ngreater\tO\nhypotensive\tB-Disease\neffects\tO\n.\tO\n\nAntiparkinsonian\tO\neffects\tO\nof\tO\nlevodopa\tB-Chemical\ntemporally\tO\ncorrelated\tO\nwith\tO\nblood\tO\npressure\tO\nchanges\tO\n.\tO\n\nPhenylalanine\tB-Chemical\n,\tO\na\tO\nlarge\tO\nneutral\tO\namino\tB-Chemical\nacid\tI-Chemical\n(\tO\nLNAA\tO\n)\tO\ncompeting\tO\nwith\tO\nlevodopa\tB-Chemical\nfor\tO\ntransport\tO\nacross\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n,\tO\nreduced\tO\nthe\tO\nhypotensive\tB-Disease\nand\tO\nantiparkinsonian\tO\neffects\tO\nof\tO\nlevodopa\tB-Chemical\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nlevodopa\tB-Chemical\nhas\tO\na\tO\ncentral\tO\nhypotensive\tB-Disease\naction\tO\nthat\tO\nparallels\tO\nthe\tO\nmotor\tO\neffects\tO\nin\tO\nfluctuating\tO\npatients\tO\n.\tO\n\nThe\tO\nhypotensive\tB-Disease\neffect\tO\nappears\tO\nto\tO\nbe\tO\nrelated\tO\nto\tO\nthe\tO\nhigher\tO\nbaseline\tO\nblood\tO\npressure\tO\nwe\tO\nobserved\tO\nin\tO\nfluctuating\tO\npatients\tO\nrelative\tO\nto\tO\nstable\tO\npatients\tO\n.\tO\n\nSyndrome\tB-Disease\nof\tI-Disease\ninappropriate\tI-Disease\nsecretion\tI-Disease\nof\tI-Disease\nantidiuretic\tI-Disease\nhormone\tI-Disease\nafter\tO\ninfusional\tO\nvincristine\tB-Chemical\n.\tO\n\nA\tO\n77\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nrefractory\tO\nmultiple\tB-Disease\nmyeloma\tI-Disease\nwas\tO\ntreated\tO\nwith\tO\na\tO\n4\tO\n-\tO\nday\tO\ncontinuous\tO\nintravenous\tO\ninfusion\tO\nof\tO\nvincristine\tB-Chemical\nand\tO\ndoxorubicin\tB-Chemical\nand\tO\n4\tO\ndays\tO\nof\tO\noral\tO\ndexamethasone\tB-Chemical\n.\tO\n\nNine\tO\ndays\tO\nafter\tO\nher\tO\nsecond\tO\ncycle\tO\nshe\tO\npresented\tO\nwith\tO\nlethargy\tB-Disease\nand\tO\nweakness\tB-Disease\nassociated\tO\nwith\tO\nhyponatremia\tB-Disease\n.\tO\n\nEvaluation\tO\nrevealed\tO\nthe\tO\nsyndrome\tB-Disease\nof\tI-Disease\ninappropriate\tI-Disease\nsecretion\tI-Disease\nof\tI-Disease\nantidiuretic\tI-Disease\nhormone\tI-Disease\n,\tO\nwhich\tO\nwas\tO\nattributed\tO\nto\tO\nthe\tO\nvincristine\tB-Chemical\ninfusion\tO\n.\tO\n\nAfter\tO\nnormal\tO\nserum\tO\nsodium\tB-Chemical\nlevels\tO\nreturned\tO\n,\tO\nfurther\tO\ndoxorubicin\tB-Chemical\nand\tO\ndexamethasone\tB-Chemical\nchemotherapy\tO\nwithout\tO\nvincristine\tB-Chemical\ndid\tO\nnot\tO\nproduce\tO\nthis\tO\ncomplication\tO\n.\tO\n\nHeart\tB-Disease\nfailure\tI-Disease\n:\tO\nto\tO\ndigitalise\tO\nor\tO\nnot\tO\n?\tO\n\nThe\tO\nview\tO\nagainst\tO\n.\tO\n\nDespite\tO\nextensive\tO\nclinical\tO\nexperience\tO\nthe\tO\nrole\tO\nof\tO\ndigoxin\tB-Chemical\nis\tO\nstill\tO\nnot\tO\nwell\tO\ndefined\tO\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\natrial\tB-Disease\nfibrillation\tI-Disease\ndigoxin\tB-Chemical\nis\tO\nbeneficial\tO\nfor\tO\nventricular\tO\nrate\tO\ncontrol\tO\n.\tO\n\nFor\tO\npatients\tO\nin\tO\nsinus\tO\nrhythm\tO\nand\tO\nheart\tB-Disease\nfailure\tI-Disease\nthe\tO\nsituation\tO\nis\tO\nless\tO\nclear\tO\n.\tO\n\nDigoxin\tB-Chemical\nhas\tO\na\tO\nnarrow\tO\ntherapeutic\tO\n:\tO\ntoxic\tO\nratio\tO\nand\tO\nconcentrations\tO\nare\tO\naffected\tO\nby\tO\na\tO\nnumber\tO\nof\tO\ndrugs\tO\n.\tO\n\nAlso\tO\n,\tO\ndigoxin\tB-Chemical\nhas\tO\nundesirable\tO\neffects\tO\nsuch\tO\nas\tO\nincreasing\tO\nperipheral\tO\nresistance\tO\nand\tO\nmyocardial\tO\ndemands\tO\n,\tO\nand\tO\ncausing\tO\narrhythmias\tB-Disease\n.\tO\n\nThere\tO\nis\tO\na\tO\npaucity\tO\nof\tO\ndata\tO\nfrom\tO\nwell\tO\n-\tO\ndesigned\tO\ntrials\tO\n.\tO\n\nThe\tO\ntrials\tO\nthat\tO\nare\tO\navailable\tO\nare\tO\ngenerally\tO\nsmall\tO\nwith\tO\nlimitations\tO\nin\tO\ndesign\tO\nand\tO\nthese\tO\nshow\tO\nvariation\tO\nin\tO\npatient\tO\nbenefit\tO\n.\tO\n\nMore\tO\nconvincing\tO\nevidence\tO\nis\tO\nrequired\tO\nshowing\tO\nthat\tO\ndigoxin\tB-Chemical\nimproves\tO\nsymptoms\tO\nor\tO\nexercise\tO\ncapacity\tO\n.\tO\n\nFurthermore\tO\n,\tO\nno\tO\ntrial\tO\nhas\tO\nhad\tO\nsufficient\tO\npower\tO\nto\tO\nevaluate\tO\nmortality\tO\n.\tO\n\nPooled\tO\nanalysis\tO\nof\tO\nthe\tO\neffects\tO\nof\tO\nother\tO\ninotropic\tO\ndrugs\tO\nshows\tO\nan\tO\nexcess\tO\nmortality\tO\nand\tO\nthere\tO\nis\tO\na\tO\npossibility\tO\nthat\tO\ndigoxin\tB-Chemical\nmay\tO\nincrease\tO\nmortality\tO\nafter\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n(\tO\nMI\tB-Disease\n)\tO\n.\tO\n\nAngiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\n(\tO\nACE\tO\n)\tO\ninhibitors\tO\nshould\tO\nbe\tO\nused\tO\nfirst\tO\nas\tO\nthey\tO\nare\tO\nsafer\tO\n,\tO\ndo\tO\nnot\tO\nrequire\tO\nblood\tO\nlevel\tO\nmonitoring\tO\n,\tO\nmodify\tO\nprogression\tO\nof\tO\ndisease\tO\n,\tO\nrelieve\tO\nsymptoms\tO\n,\tO\nimprove\tO\nexercise\tO\ntolerance\tO\nand\tO\nreduce\tO\nmortality\tO\n.\tO\n\nCaution\tO\nshould\tO\nbe\tO\nexercised\tO\nin\tO\nusing\tO\ndigoxin\tB-Chemical\nuntil\tO\nlarge\tO\nmortality\tO\ntrials\tO\nare\tO\ncompleted\tO\nshowing\tO\neither\tO\nbenefit\tO\nor\tO\nharm\tO\n.\tO\n\nUntil\tO\nthen\tO\ndigoxin\tB-Chemical\nshould\tO\nbe\tO\nconsidered\tO\na\tO\nthird\tO\n-\tO\nline\tO\ntherapy\tO\n.\tO\n\nIsradipine\tB-Chemical\ntreatment\tO\nfor\tO\nhypertension\tB-Disease\nin\tO\ngeneral\tO\npractice\tO\nin\tO\nHong\tO\nKong\tO\n.\tO\n\nA\tO\n6\tO\n-\tO\nweek\tO\nopen\tO\nstudy\tO\nof\tO\nthe\tO\nintroduction\tO\nof\tO\nisradipine\tB-Chemical\ntreatment\tO\nwas\tO\nconducted\tO\nin\tO\ngeneral\tO\npractice\tO\nin\tO\nHong\tO\nKong\tO\n.\tO\n\n303\tO\nChinese\tO\npatients\tO\nwith\tO\nmild\tO\nto\tO\nmoderate\tO\nhypertension\tB-Disease\nentered\tO\nthe\tO\nstudy\tO\n.\tO\n\nSide\tO\neffects\tO\nwere\tO\nreported\tO\nin\tO\n21\tO\n%\tO\nof\tO\npatients\tO\nand\tO\ncaused\tO\nwithdrawal\tO\nfrom\tO\nthe\tO\nstudy\tO\nin\tO\n3\tO\npatients\tO\n.\tO\n\nThe\tO\nmain\tO\nside\tO\n-\tO\neffects\tO\nwere\tO\nheadache\tB-Disease\n,\tO\ndizziness\tB-Disease\n,\tO\npalpitation\tB-Disease\nand\tO\nflushing\tB-Disease\nand\tO\nthese\tO\nwere\tO\nnot\tO\nmore\tO\nfrequent\tO\nthan\tO\nreported\tO\nin\tO\nother\tO\nstudies\tO\nwith\tO\nisradipine\tB-Chemical\nor\tO\nwith\tO\nplacebo\tO\n.\tO\n\nSupine\tO\nblood\tO\npressure\tO\nwas\tO\nreduced\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\nfrom\tO\n170\tO\n+\tO\n/\tO\n-\tO\n20\tO\n/\tO\n102\tO\n+\tO\n/\tO\n-\tO\n6\tO\nmmHg\tO\nto\tO\n153\tO\n+\tO\n/\tO\n-\tO\n19\tO\n/\tO\n92\tO\n+\tO\n/\tO\n-\tO\n8\tO\n,\tO\n147\tO\n+\tO\n/\tO\n-\tO\n18\tO\n/\tO\n88\tO\n+\tO\n/\tO\n-\tO\n7\tO\nand\tO\n144\tO\n+\tO\n/\tO\n-\tO\n14\tO\n/\tO\n87\tO\n+\tO\n/\tO\n-\tO\n6\tO\nmmHg\tO\nat\tO\n2\tO\n,\tO\n4\tO\nand\tO\n6\tO\nweeks\tO\nrespectively\tO\nin\tO\nevaluable\tO\npatients\tO\n.\tO\n\nSimilar\tO\nreductions\tO\noccurred\tO\nin\tO\nstanding\tO\nblood\tO\npressure\tO\nand\tO\nthere\tO\nwas\tO\nno\tO\nevidence\tO\nof\tO\npostural\tB-Disease\nhypotension\tI-Disease\n.\tO\n\nNormalization\tO\nand\tO\nresponder\tO\nrates\tO\nat\tO\n6\tO\nweeks\tO\nwere\tO\n86\tO\n%\tO\nand\tO\n69\tO\n%\tO\nrespectively\tO\n.\tO\n\nDosage\tO\nwas\tO\nincreased\tO\nfrom\tO\n2\tO\n.\tO\n5\tO\nmg\tO\nb\tO\n.\tO\nd\tO\n.\tO\nto\tO\n5\tO\nmg\tO\nb\tO\n.\tO\nd\tO\n.\tO\nat\tO\n4\tO\nweeks\tO\nin\tO\npatients\tO\nwith\tO\ndiastolic\tO\nblood\tO\npressure\tO\ngreater\tO\nthan\tO\n90\tO\nmmHg\tO\nand\tO\ntheir\tO\nfurther\tO\nresponse\tO\nwas\tO\ngreater\tO\nthan\tO\nthose\tO\nremaining\tO\non\tO\n2\tO\n.\tO\n5\tO\nmg\tO\nb\tO\n.\tO\nd\tO\n.\tO\n\nPharmacological\tO\ncharacteristics\tO\nand\tO\nside\tO\neffects\tO\nof\tO\na\tO\nnew\tO\ngalenic\tO\nformulation\tO\nof\tO\npropofol\tB-Chemical\nwithout\tO\nsoyabean\tO\noil\tO\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\npharmacokinetics\tO\n,\tO\npharmacodynamics\tO\nand\tO\nsafety\tO\nprofile\tO\nof\tO\na\tO\nnew\tO\ngalenic\tO\nformulation\tO\nof\tO\npropofol\tB-Chemical\n(\tO\nAM149\tO\n1\tO\n%\tO\n)\tO\n,\tO\nwhich\tO\ndoes\tO\nnot\tO\ncontain\tO\nsoyabean\tO\noil\tO\n,\tO\nwith\tO\na\tO\nstandard\tO\nformulation\tO\nof\tO\npropofol\tB-Chemical\n(\tO\nDisoprivan\tB-Chemical\n1\tO\n%\tO\n)\tO\n.\tO\n\nIn\tO\na\tO\nrandomised\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncross\tO\n-\tO\nover\tO\nstudy\tO\n,\tO\n30\tO\nhealthy\tO\nvolunteers\tO\nreceived\tO\na\tO\nsingle\tO\nintravenous\tO\nbolus\tO\ninjection\tO\nof\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n.\tO\nkg\tO\n-\tO\n1\tO\npropofol\tB-Chemical\n.\tO\n\nPlasma\tO\npropofol\tB-Chemical\nlevels\tO\nwere\tO\nmeasured\tO\nfor\tO\n48\tO\nh\tO\nfollowing\tO\ndrug\tO\nadministration\tO\nand\tO\nevaluated\tO\naccording\tO\nto\tO\na\tO\nthree\tO\n-\tO\ncompartment\tO\nmodel\tO\n.\tO\n\nThe\tO\npharmacodynamic\tO\nparameters\tO\nassessed\tO\nincluded\tO\ninduction\tO\nand\tO\nemergence\tO\ntimes\tO\n,\tO\nrespiratory\tO\nand\tO\ncardiovascular\tO\neffects\tO\n,\tO\nand\tO\npain\tB-Disease\non\tO\ninjection\tO\n.\tO\n\nPatients\tO\nwere\tO\nmonitored\tO\nfor\tO\nside\tO\neffects\tO\nover\tO\n48\tO\nh\tO\n.\tO\n\nOwing\tO\nto\tO\na\tO\nhigh\tO\nincidence\tO\nof\tO\nthrombophlebitis\tB-Disease\n,\tO\nthe\tO\nstudy\tO\nwas\tO\nterminated\tO\nprematurely\tO\nand\tO\nonly\tO\nthe\tO\ndata\tO\nof\tO\nthe\tO\ntwo\tO\nparallel\tO\ntreatment\tO\ngroups\tO\n(\tO\n15\tO\npatients\tO\nin\tO\neach\tO\ngroup\tO\n)\tO\nwere\tO\nanalysed\tO\n.\tO\n\nPlasma\tO\nconcentrations\tO\ndid\tO\nnot\tO\ndiffer\tO\nsignificantly\tO\nbetween\tO\nthe\tO\ntwo\tO\nformulations\tO\n.\tO\n\nAnaesthesia\tO\ninduction\tO\nand\tO\nemergence\tO\ntimes\tO\n,\tO\nrespiratory\tO\nand\tO\ncardiovascular\tO\nvariables\tO\nshowed\tO\nno\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\nthe\tO\ntwo\tO\ntreatment\tO\ngroups\tO\n.\tO\n\nPain\tB-Disease\non\tO\ninjection\tO\n(\tO\n80\tO\nvs\tO\n.\tO\n20\tO\n%\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nand\tO\nthrombophlebitis\tB-Disease\n(\tO\n93\tO\n.\tO\n3\tO\nvs\tO\n.\tO\n6\tO\n.\tO\n6\tO\n%\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\noccurred\tO\nmore\tO\nfrequently\tO\nwith\tO\nAM149\tO\nthan\tO\nwith\tO\nDisoprivan\tB-Chemical\n.\tO\n\nAlthough\tO\nboth\tO\nformulations\tO\nhad\tO\nsimilar\tO\npharmacokinetic\tO\nand\tO\npharmacodynamic\tO\nprofiles\tO\nthe\tO\nnew\tO\nformulation\tO\nis\tO\nnot\tO\nsuitable\tO\nfor\tO\nclinical\tO\nuse\tO\ndue\tO\nto\tO\nthe\tO\nhigh\tO\nincidence\tO\nof\tO\nthrombophlebitis\tB-Disease\nproduced\tO\n.\tO\n\nPure\tB-Disease\nred\tI-Disease\ncell\tI-Disease\naplasia\tI-Disease\n,\tO\ntoxic\tB-Disease\ndermatitis\tI-Disease\nand\tO\nlymphadenopathy\tB-Disease\nin\tO\na\tO\npatient\tO\ntaking\tO\ndiphenylhydantoin\tB-Chemical\n.\tO\n\nA\tO\npatient\tO\ntaking\tO\ndiphenylhydantoin\tB-Chemical\nfor\tO\n3\tO\nweeks\tO\ndeveloped\tO\na\tO\ngeneralized\tO\nskin\tB-Disease\nrash\tI-Disease\n,\tO\nlymphadenopathy\tB-Disease\nand\tO\npure\tB-Disease\nred\tI-Disease\ncell\tI-Disease\naplasia\tI-Disease\n.\tO\n\nAfter\tO\nwithdrawal\tO\nof\tO\nthe\tO\npharmacon\tO\nall\tO\nsymptoms\tO\ndisappeared\tO\nspontaneously\tO\n.\tO\n\nSkin\tB-Disease\nrash\tI-Disease\nis\tO\na\tO\nwell\tO\n-\tO\nknown\tO\ncomplication\tO\nof\tO\ndiphenylhydantoin\tB-Chemical\ntreatment\tO\nas\tO\nis\tO\nbenign\tO\nand\tO\nmalignant\tO\nlymphadenopathy\tB-Disease\n.\tO\n\nPure\tB-Disease\nred\tI-Disease\ncell\tI-Disease\naplasia\tI-Disease\nassociated\tO\nwith\tO\ndiphenylhydantoin\tB-Chemical\nmedication\tO\nhas\tO\nbeen\tO\nreported\tO\nin\tO\n3\tO\npatients\tO\n.\tO\n\nThe\tO\nexact\tO\nmechanism\tO\nby\tO\nwhich\tO\ndiphenylhydantoin\tB-Chemical\nexerts\tO\nits\tO\ntoxic\tO\neffects\tO\nis\tO\nnot\tO\nknown\tO\n.\tO\n\nIn\tO\nthis\tO\npatient\tO\nthe\tO\ntime\tO\nrelation\tO\nbetween\tO\nthe\tO\ningestion\tO\nof\tO\ndiphenylhydantoin\tB-Chemical\nand\tO\nthe\tO\noccurrence\tO\nof\tO\nthe\tO\nskin\tB-Disease\nrash\tI-Disease\n,\tO\nlymphadenopathy\tB-Disease\nand\tO\npure\tB-Disease\nred\tI-Disease\ncell\tI-Disease\naplasia\tI-Disease\nis\tO\nvery\tO\nsuggestive\tO\nof\tO\na\tO\ndirect\tO\nconnection\tO\n.\tO\n\nVinorelbine\tB-Chemical\n-\tO\nrelated\tO\ncardiac\tO\nevents\tO\n:\tO\na\tO\nmeta\tO\n-\tO\nanalysis\tO\nof\tO\nrandomized\tO\nclinical\tO\ntrials\tO\n.\tO\n\nSeveral\tO\ncases\tO\nof\tO\ncardiac\tO\nadverse\tO\nreactions\tO\nrelated\tO\nto\tO\nvinorelbine\tB-Chemical\n(\tO\nVNR\tB-Chemical\n)\tO\nhave\tO\nbeen\tO\nreported\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\nquantify\tO\nthe\tO\nincidence\tO\nof\tO\nthese\tO\ncardiac\tO\nevents\tO\n,\tO\nwe\tO\nperformed\tO\na\tO\nmeta\tO\n-\tO\nanalysis\tO\nof\tO\nclinical\tO\ntrials\tO\ncomparing\tO\nVNR\tB-Chemical\nwith\tO\nother\tO\nchemotherapeutic\tO\nagents\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nvarious\tO\nmalignancies\tB-Disease\n.\tO\n\nRandomized\tO\nclinical\tO\ntrials\tO\ncomparing\tO\nVNR\tB-Chemical\nwith\tO\nother\tO\ndrugs\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\ncancer\tB-Disease\nwere\tO\nsearched\tO\nin\tO\nMedline\tO\n,\tO\nEmbase\tO\n,\tO\nEvidence\tO\n-\tO\nbased\tO\nMedicine\tO\nReviews\tO\ndatabases\tO\nand\tO\nthe\tO\nCochrane\tO\nlibrary\tO\nfrom\tO\n1987\tO\nto\tO\n2002\tO\n.\tO\n\nOutcomes\tO\nof\tO\ninterest\tO\nwere\tO\nsevere\tO\ncardiac\tO\nevents\tO\n,\tO\ntoxic\tO\ndeaths\tO\nand\tO\ncardiac\tO\nevent\tO\n-\tO\nrelated\tO\ndeaths\tO\nreported\tO\nin\tO\neach\tO\npublication\tO\n.\tO\n\nWe\tO\nfound\tO\n19\tO\ntrials\tO\n,\tO\ninvolving\tO\n2441\tO\npatients\tO\ntreated\tO\nby\tO\nVNR\tB-Chemical\nand\tO\n2050\tO\ncontrol\tO\npatients\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ncardiac\tO\nevents\tO\nwith\tO\nVNR\tB-Chemical\nwas\tO\n1\tO\n.\tO\n19\tO\n%\tO\n[\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n(\tO\nCI\tO\n)\tO\n(\tO\n0\tO\n.\tO\n75\tO\n;\tO\n1\tO\n.\tO\n67\tO\n)\tO\n]\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\ndifference\tO\nin\tO\nthe\tO\nrisk\tO\nof\tO\ncardiac\tO\nevents\tO\nbetween\tO\nVNR\tB-Chemical\nand\tO\nother\tO\ndrugs\tO\n[\tO\nodds\tO\nratio\tO\n:\tO\n0\tO\n.\tO\n92\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n(\tO\n0\tO\n.\tO\n54\tO\n;\tO\n1\tO\n.\tO\n55\tO\n)\tO\n]\tO\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nVNR\tB-Chemical\ncardiac\tO\nevents\tO\nwas\tO\nsimilar\tO\nto\tO\nvindesine\tB-Chemical\n(\tO\nVDS\tB-Chemical\n)\tO\nand\tO\nother\tO\ncardiotoxic\tB-Disease\ndrugs\tO\n[\tO\nfluorouracil\tB-Chemical\n,\tO\nanthracyclines\tB-Chemical\n,\tO\ngemcitabine\tB-Chemical\n(\tO\nGEM\tB-Chemical\n)\tO\nem\tO\nleader\tO\n]\tO\n.\tO\n\nEven\tO\nif\tO\nit\tO\ndid\tO\nnot\tO\nreach\tO\nstatistical\tO\nsignificance\tO\nbecause\tO\nof\tO\na\tO\nfew\tO\nnumber\tO\nof\tO\ncases\tO\n,\tO\nthe\tO\nrisk\tO\nwas\tO\nlower\tO\nin\tO\ntrials\tO\nexcluding\tO\npatients\tO\nwith\tO\ncardiac\tO\nhistory\tO\n,\tO\nand\tO\nseemed\tO\nto\tO\nbe\tO\nhigher\tO\nin\tO\ntrials\tO\nincluding\tO\npatients\tO\nwith\tO\npre\tO\n-\tO\nexisting\tO\ncardiac\tB-Disease\ndiseases\tI-Disease\n.\tO\n\nVinorelbine\tB-Chemical\n-\tO\nrelated\tO\ncardiac\tO\nevents\tO\nconcern\tO\nabout\tO\n1\tO\n%\tO\nof\tO\ntreated\tO\npatients\tO\nin\tO\nclinical\tO\ntrials\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nrisk\tO\nassociated\tO\nwith\tO\nVNR\tB-Chemical\nseems\tO\nto\tO\nbe\tO\nsimilar\tO\nto\tO\nthat\tO\nof\tO\nother\tO\nchemotherapeutic\tO\nagents\tO\nin\tO\nthe\tO\nsame\tO\nindications\tO\n.\tO\n\nMRI\tO\nfindings\tO\nof\tO\nhypoxic\tO\ncortical\tO\nlaminar\tO\nnecrosis\tB-Disease\nin\tO\na\tO\nchild\tO\nwith\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\ncrisis\tO\n.\tO\n\nWe\tO\npresent\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nfindings\tO\nof\tO\na\tO\n5\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ngirl\tO\nwho\tO\nhad\tO\na\tO\nrapidly\tO\ninstalling\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\ncrisis\tO\ninduced\tO\nby\tO\ntrimethoprim\tB-Chemical\n-\tI-Chemical\nsulfomethoxazole\tI-Chemical\n,\tO\nresulting\tO\nin\tO\ncerebral\tB-Disease\nanoxia\tI-Disease\nleading\tO\nto\tO\npermanent\tO\ndamage\tO\n.\tO\n\nMagnetic\tO\nResonance\tO\nimaging\tO\nrevealed\tO\ncortical\tO\nlaminar\tO\nnecrosis\tB-Disease\nin\tO\narterial\tO\nborder\tO\nzones\tO\nin\tO\nboth\tO\ncerebral\tO\nhemispheres\tO\n,\tO\nischemic\tO\nchanges\tO\nin\tO\nsubcortical\tO\nwhite\tO\nmatter\tO\nof\tO\nleft\tO\ncerebral\tO\nhemisphere\tO\n,\tO\nand\tO\nin\tO\nthe\tO\nleft\tO\nputamen\tO\n.\tO\n\nAlthough\tO\ncortical\tO\nlaminar\tO\nnecrosis\tB-Disease\nis\tO\na\tO\nclassic\tO\nentity\tO\nin\tO\nadulthood\tO\nrelated\tO\nto\tO\nconditions\tO\nof\tO\nenergy\tO\ndepletions\tO\n,\tO\nthere\tO\nare\tO\nfew\tO\nreports\tO\navailable\tO\nin\tO\nchildren\tO\n.\tO\n\nA\tO\nwide\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\nis\tO\nalso\tO\npresented\tO\n.\tO\n\nThe\tO\nnatural\tO\nhistory\tO\nof\tO\nVigabatrin\tB-Chemical\nassociated\tO\nvisual\tB-Disease\nfield\tI-Disease\ndefects\tI-Disease\nin\tO\npatients\tO\nelecting\tO\nto\tO\ncontinue\tO\ntheir\tO\nmedication\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nnatural\tO\nhistory\tO\nof\tO\nvisual\tB-Disease\nfield\tI-Disease\ndefects\tI-Disease\nin\tO\na\tO\ngroup\tO\nof\tO\npatients\tO\nknown\tO\nto\tO\nhave\tO\nVigabatrin\tB-Chemical\n-\tO\nassociated\tO\nchanges\tO\nwho\tO\nelected\tO\nto\tO\ncontinue\tO\nthe\tO\nmedication\tO\nbecause\tO\nof\tO\ngood\tO\nseizure\tB-Disease\ncontrol\tO\n.\tO\n\nMETHODS\tO\n:\tO\nAll\tO\npatients\tO\ntaking\tO\nVigabatrin\tB-Chemical\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nother\tO\nantiepileptic\tO\ndrugs\tO\nfor\tO\nat\tO\nleast\tO\n5\tO\nyears\tO\n(\tO\nrange\tO\n5\tO\n-\tO\n12\tO\nyears\tO\n)\tO\nwere\tO\nentered\tO\ninto\tO\na\tO\nvisual\tO\nsurveillance\tO\nprogramme\tO\n.\tO\n\nPatients\tO\nwere\tO\nfollowed\tO\nup\tO\nat\tO\n6\tO\n-\tO\nmonthly\tO\nintervals\tO\nfor\tO\nnot\tO\nless\tO\nthan\tO\n18\tO\nmonths\tO\n(\tO\nrange\tO\n18\tO\n-\tO\n43\tO\nmonths\tO\n)\tO\n.\tO\n\nIn\tO\nall\tO\n,\tO\n16\tO\npatients\tO\nwith\tO\nunequivocal\tO\ndefects\tO\ncontinued\tO\nthe\tO\nmedication\tO\n.\tO\n\nFollowing\tO\nalready\tO\npublished\tO\nmethodology\tO\n(\tO\nEye\tO\n2002\tO\n;\tO\n16\tO\n;\tO\n567\tO\n-\tO\n571\tO\n)\tO\nmonocular\tO\nmean\tO\nradial\tO\ndegrees\tO\n(\tO\nMRDs\tO\n)\tO\nto\tO\nthe\tO\nI\tO\n/\tO\n4e\tO\nisopter\tO\non\tO\nGoldmann\tO\nperimetry\tO\nwas\tO\ncalculated\tO\nfor\tO\nthe\tO\nright\tO\neye\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\ndiscovery\tO\nof\tO\na\tO\nvisual\tB-Disease\nfield\tI-Disease\ndefect\tI-Disease\nand\tO\nagain\tO\nafter\tO\nnot\tO\nless\tO\nthan\tO\n18\tO\nmonths\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nRESULTS\tO\n:\tO\nMean\tO\nright\tO\neye\tO\nMRD\tO\nat\tO\npresentation\tO\nwas\tO\n36\tO\n.\tO\n98\tO\ndegrees\tO\n(\tO\nrange\tO\n22\tO\n.\tO\n25\tO\n-\tO\n51\tO\n.\tO\n0\tO\n)\tO\n,\tO\ncompared\tO\nto\tO\n38\tO\n.\tO\n40\tO\ndegrees\tO\n(\tO\nrange\tO\n22\tO\n.\tO\n5\tO\n-\tO\n49\tO\n.\tO\n75\tO\n)\tO\nafter\tO\nfollow\tO\n-\tO\nup\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n338\tO\nunpaired\tO\nt\tO\n-\tO\ntest\tO\n.\tO\n\nOnly\tO\none\tO\npatient\tO\ndemonstrated\tO\na\tO\ndeterioration\tB-Disease\nin\tI-Disease\nvisual\tI-Disease\nfield\tI-Disease\nduring\tO\nthe\tO\nstudy\tO\nperiod\tO\nand\tO\ndiscontinued\tO\ntreatment\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nEstablished\tO\nvisual\tB-Disease\nfield\tI-Disease\ndefects\tI-Disease\npresumed\tO\nto\tO\nbe\tO\ndue\tO\nto\tO\nVigabatrin\tB-Chemical\ntherapy\tO\ndid\tO\nnot\tO\nusually\tO\nprogress\tO\nin\tO\nspite\tO\nof\tO\ncontinuing\tO\nuse\tO\nof\tO\nthe\tO\nmedication\tO\n.\tO\n\nThese\tO\ndata\tO\ngive\tO\nsupport\tO\nto\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\npathogenesis\tO\nof\tO\nVigabatrin\tB-Chemical\n-\tO\nassociated\tO\nvisual\tB-Disease\nfield\tI-Disease\ndefects\tI-Disease\nmay\tO\nbe\tO\nan\tO\nidiosyncratic\tO\nadverse\tO\ndrug\tO\nreaction\tO\nrather\tO\nthan\tO\ndose\tO\n-\tO\ndependent\tO\ntoxicity\tB-Disease\n.\tO\n\nInduction\tO\nof\tO\nrosaceiform\tO\ndermatitis\tB-Disease\nduring\tO\ntreatment\tO\nof\tO\nfacial\tB-Disease\ninflammatory\tI-Disease\ndermatoses\tI-Disease\nwith\tO\ntacrolimus\tB-Chemical\nointment\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nTacrolimus\tB-Chemical\nointment\tO\nis\tO\nincreasingly\tO\nused\tO\nfor\tO\nanti\tO\n-\tO\ninflammatory\tO\ntreatment\tO\nof\tO\nsensitive\tO\nareas\tO\nsuch\tO\nas\tO\nthe\tO\nface\tO\n,\tO\nand\tO\nrecent\tO\nobservations\tO\nindicate\tO\nthat\tO\nthe\tO\ntreatment\tO\nis\tO\neffective\tO\nin\tO\nsteroid\tB-Chemical\n-\tO\naggravated\tO\nrosacea\tB-Disease\nand\tO\nperioral\tB-Disease\ndermatitis\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\non\tO\nrosaceiform\tO\ndermatitis\tB-Disease\nas\tO\na\tO\ncomplication\tO\nof\tO\ntreatment\tO\nwith\tO\ntacrolimus\tB-Chemical\nointment\tO\n.\tO\n\nOBSERVATIONS\tO\n:\tO\nSix\tO\nadult\tO\npatients\tO\nwith\tO\ninflammatory\tB-Disease\nfacial\tI-Disease\ndermatoses\tI-Disease\nwere\tO\ntreated\tO\nwith\tO\ntacrolimus\tB-Chemical\nointment\tO\nbecause\tO\nof\tO\nthe\tO\nineffectiveness\tO\nof\tO\nstandard\tO\ntreatments\tO\n.\tO\n\nWithin\tO\n2\tO\nto\tO\n3\tO\nweeks\tO\nof\tO\ninitially\tO\neffective\tO\nand\tO\nwell\tO\n-\tO\ntolerated\tO\ntreatment\tO\n,\tO\n3\tO\npatients\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nrosacea\tB-Disease\nand\tO\n1\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nacne\tB-Disease\nexperienced\tO\nsudden\tO\nworsening\tO\nwith\tO\npustular\tO\nrosaceiform\tO\nlesions\tO\n.\tO\n\nBiopsy\tO\nrevealed\tO\nan\tO\nabundance\tO\nof\tO\nDemodex\tO\nmites\tO\nin\tO\n2\tO\nof\tO\nthese\tO\npatients\tO\n.\tO\n\nIn\tO\n1\tO\npatient\tO\nwith\tO\neyelid\tO\neczema\tB-Disease\n,\tO\nrosaceiform\tO\nperiocular\tB-Disease\ndermatitis\tI-Disease\ngradually\tO\nappeared\tO\nafter\tO\n3\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nIn\tO\n1\tO\npatient\tO\nwith\tO\natopic\tB-Disease\ndermatitis\tI-Disease\n,\tO\ntelangiectatic\tO\nand\tO\npapular\tB-Disease\nrosacea\tI-Disease\ninsidiously\tO\nappeared\tO\nafter\tO\n5\tO\nmonths\tO\nof\tO\ntreatment\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nOur\tO\nobservations\tO\nsuggest\tO\nthat\tO\nthe\tO\nspectrum\tO\nof\tO\nrosaceiform\tO\ndermatitis\tB-Disease\nas\tO\na\tO\ncomplication\tO\nof\tO\ntreatment\tO\nwith\tO\ntacrolimus\tB-Chemical\nointment\tO\nis\tO\nheterogeneous\tO\n.\tO\n\nA\tO\nvariety\tO\nof\tO\nfactors\tO\n,\tO\nsuch\tO\nas\tO\nvasoactive\tO\nproperties\tO\nof\tO\ntacrolimus\tB-Chemical\n,\tO\nproliferation\tO\nof\tO\nDemodex\tO\ndue\tO\nto\tO\nlocal\tO\nimmunosuppression\tO\n,\tO\nand\tO\nthe\tO\nocclusive\tO\nproperties\tO\nof\tO\nthe\tO\nointment\tO\n,\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\nobserved\tO\nphenomena\tO\n.\tO\n\nFuture\tO\nstudies\tO\nare\tO\nneeded\tO\nto\tO\nidentify\tO\nindividual\tO\nrisk\tO\nfactors\tO\n.\tO\n\nIntravascular\tO\nhemolysis\tB-Disease\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nfollowing\tO\nintermittent\tO\nrifampin\tB-Chemical\ntherapy\tO\n.\tO\n\nRenal\tB-Disease\nfailure\tI-Disease\nis\tO\na\tO\nrare\tO\ncomplication\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nrifampin\tB-Chemical\n.\tO\n\nIntravascular\tO\nhemolysis\tB-Disease\nleading\tO\nto\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nfollowing\tO\nrifampin\tB-Chemical\ntherapy\tO\nis\tO\nextremely\tO\nrare\tO\n.\tO\n\nTwo\tO\npatients\tO\nwith\tO\nleprosy\tB-Disease\nwho\tO\ndeveloped\tO\nhemolysis\tB-Disease\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nfollowing\tO\nrifampin\tB-Chemical\nare\tO\nreported\tO\n.\tO\n\nStructural\tO\nabnormalities\tO\nin\tO\nthe\tO\nbrains\tO\nof\tO\nhuman\tO\nsubjects\tO\nwho\tO\nuse\tO\nmethamphetamine\tB-Chemical\n.\tO\n\nWe\tO\nvisualize\tO\n,\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\n,\tO\nthe\tO\nprofile\tO\nof\tO\nstructural\tB-Disease\ndeficits\tI-Disease\nin\tI-Disease\nthe\tI-Disease\nhuman\tI-Disease\nbrain\tI-Disease\nassociated\tO\nwith\tO\nchronic\tO\nmethamphetamine\tB-Chemical\n(\tO\nMA\tB-Chemical\n)\tO\nabuse\tO\n.\tO\n\nStudies\tO\nof\tO\nhuman\tO\nsubjects\tO\nwho\tO\nhave\tO\nused\tO\nMA\tB-Chemical\nchronically\tO\nhave\tO\nrevealed\tO\ndeficits\tO\nin\tO\ndopaminergic\tO\nand\tO\nserotonergic\tO\nsystems\tO\nand\tO\ncerebral\tO\nmetabolic\tB-Disease\nabnormalities\tI-Disease\n.\tO\n\nUsing\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n(\tO\nMRI\tO\n)\tO\nand\tO\nnew\tO\ncomputational\tO\nbrain\tO\n-\tO\nmapping\tO\ntechniques\tO\n,\tO\nwe\tO\ndetermined\tO\nthe\tO\npattern\tO\nof\tO\nstructural\tO\nbrain\tO\nalterations\tO\nassociated\tO\nwith\tO\nchronic\tO\nMA\tB-Chemical\nabuse\tO\nin\tO\nhuman\tO\nsubjects\tO\nand\tO\nrelated\tO\nthese\tO\ndeficits\tO\nto\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nWe\tO\nused\tO\nhigh\tO\n-\tO\nresolution\tO\nMRI\tO\nand\tO\nsurface\tO\n-\tO\nbased\tO\ncomputational\tO\nimage\tO\nanalyses\tO\nto\tO\nmap\tO\nregional\tO\nabnormalities\tB-Disease\nin\tI-Disease\nthe\tI-Disease\ncortex\tI-Disease\n,\tI-Disease\nhippocampus\tI-Disease\n,\tI-Disease\nwhite\tI-Disease\nmatter\tI-Disease\n,\tI-Disease\nand\tI-Disease\nventricles\tI-Disease\nin\tO\n22\tO\nhuman\tO\nsubjects\tO\nwho\tO\nused\tO\nMA\tB-Chemical\nand\tO\n21\tO\nage\tO\n-\tO\nmatched\tO\n,\tO\nhealthy\tO\ncontrols\tO\n.\tO\n\nCortical\tO\nmaps\tO\nrevealed\tO\nsevere\tO\ngray\tO\n-\tO\nmatter\tO\ndeficits\tO\nin\tO\nthe\tO\ncingulate\tO\n,\tO\nlimbic\tO\n,\tO\nand\tO\nparalimbic\tO\ncortices\tO\nof\tO\nMA\tB-Chemical\nabusers\tO\n(\tO\naveraging\tO\n11\tO\n.\tO\n3\tO\n%\tO\nbelow\tO\ncontrol\tO\n;\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nOn\tO\naverage\tO\n,\tO\nMA\tB-Chemical\nabusers\tO\nhad\tO\n7\tO\n.\tO\n8\tO\n%\tO\nsmaller\tO\nhippocampal\tO\nvolumes\tO\nthan\tO\ncontrol\tO\nsubjects\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n;\tO\nleft\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n01\tO\n;\tO\nright\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nsignificant\tO\nwhite\tO\n-\tO\nmatter\tO\nhypertrophy\tB-Disease\n(\tO\n7\tO\n.\tO\n0\tO\n%\tO\n;\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nHippocampal\tO\ndeficits\tO\nwere\tO\nmapped\tO\nand\tO\ncorrelated\tO\nwith\tO\nmemory\tO\nperformance\tO\non\tO\na\tO\nword\tO\n-\tO\nrecall\tO\ntest\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nMRI\tO\n-\tO\nbased\tO\nmaps\tO\nsuggest\tO\nthat\tO\nchronic\tO\nmethamphetamine\tB-Chemical\nabuse\tO\ncauses\tO\na\tO\nselective\tO\npattern\tO\nof\tO\ncerebral\tO\ndeterioration\tO\nthat\tO\ncontributes\tO\nto\tO\nimpaired\tB-Disease\nmemory\tI-Disease\nperformance\tI-Disease\n.\tO\n\nMA\tB-Chemical\nmay\tO\nselectively\tO\ndamage\tO\nthe\tO\nmedial\tO\ntemporal\tO\nlobe\tO\nand\tO\n,\tO\nconsistent\tO\nwith\tO\nmetabolic\tO\nstudies\tO\n,\tO\nthe\tO\ncingulate\tO\n-\tO\nlimbic\tO\ncortex\tO\n,\tO\ninducing\tO\nneuroadaptation\tO\n,\tO\nneuropil\tO\nreduction\tO\n,\tO\nor\tO\ncell\tO\ndeath\tO\n.\tO\n\nProminent\tO\nwhite\tO\n-\tO\nmatter\tO\nhypertrophy\tB-Disease\nmay\tO\nresult\tO\nfrom\tO\naltered\tO\nmyelination\tO\nand\tO\nadaptive\tO\nglial\tO\nchanges\tO\n,\tO\nincluding\tO\ngliosis\tB-Disease\nsecondary\tO\nto\tO\nneuronal\tB-Disease\ndamage\tI-Disease\n.\tO\n\nThese\tO\nbrain\tO\nsubstrates\tO\nmay\tO\nhelp\tO\naccount\tO\nfor\tO\nthe\tO\nsymptoms\tO\nof\tO\nMA\tB-Chemical\nabuse\tO\n,\tO\nproviding\tO\ntherapeutic\tO\ntargets\tO\nfor\tO\ndrug\tO\n-\tO\ninduced\tO\nbrain\tB-Disease\ninjury\tI-Disease\n.\tO\n\nDisruption\tO\nof\tO\nhepatic\tO\nlipid\tO\nhomeostasis\tO\nin\tO\nmice\tO\nafter\tO\namiodarone\tB-Chemical\ntreatment\tO\nis\tO\nassociated\tO\nwith\tO\nperoxisome\tO\nproliferator\tO\n-\tO\nactivated\tO\nreceptor\tO\n-\tO\nalpha\tO\ntarget\tO\ngene\tO\nactivation\tO\n.\tO\n\nAmiodarone\tB-Chemical\n,\tO\nan\tO\nefficacious\tO\nand\tO\nwidely\tO\nused\tO\nantiarrhythmic\tO\nagent\tO\n,\tO\nhas\tO\nbeen\tO\nreported\tO\nto\tO\ncause\tO\nhepatotoxicity\tB-Disease\nin\tO\nsome\tO\npatients\tO\n.\tO\n\nTo\tO\ngain\tO\ninsight\tO\ninto\tO\nthe\tO\nmechanism\tO\nof\tO\nthis\tO\nunwanted\tO\neffect\tO\n,\tO\nmice\tO\nwere\tO\nadministered\tO\nvarious\tO\ndoses\tO\nof\tO\namiodarone\tB-Chemical\nand\tO\nexamined\tO\nfor\tO\nchanges\tO\nin\tO\nhepatic\tO\nhistology\tO\nand\tO\ngene\tO\nregulation\tO\n.\tO\n\nAmiodarone\tB-Chemical\ninduced\tO\nhepatomegaly\tB-Disease\n,\tO\nhepatocyte\tO\nmicrovesicular\tO\nlipid\tO\naccumulation\tO\n,\tO\nand\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nserum\tO\ntriglycerides\tB-Chemical\nand\tO\nglucose\tB-Chemical\n.\tO\n\nNorthern\tO\nblot\tO\nanalysis\tO\nof\tO\nhepatic\tO\nRNA\tO\nrevealed\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nincrease\tO\nin\tO\nthe\tO\nexpression\tO\nof\tO\na\tO\nnumber\tO\nof\tO\ngenes\tO\ncritical\tO\nfor\tO\nfatty\tB-Chemical\nacid\tI-Chemical\noxidation\tO\n,\tO\nlipoprotein\tO\nassembly\tO\n,\tO\nand\tO\nlipid\tO\ntransport\tO\n.\tO\n\nMany\tO\nof\tO\nthese\tO\ngenes\tO\nare\tO\nregulated\tO\nby\tO\nthe\tO\nperoxisome\tO\nproliferator\tO\n-\tO\nactivated\tO\nreceptor\tO\n-\tO\nalpha\tO\n(\tO\nPPARalpha\tO\n)\tO\n,\tO\na\tO\nligand\tO\n-\tO\nactivated\tO\nnuclear\tO\nhormone\tO\nreceptor\tO\ntranscription\tO\nfactor\tO\n.\tO\n\nThe\tO\nabsence\tO\nof\tO\ninduction\tO\nof\tO\nthese\tO\ngenes\tO\nas\tO\nwell\tO\nas\tO\nhepatomegaly\tB-Disease\nin\tO\nPPARalpha\tO\nknockout\tO\n[\tO\nPPARalpha\tO\n-\tO\n/\tO\n-\tO\n]\tO\nmice\tO\nindicated\tO\nthat\tO\nthe\tO\neffects\tO\nof\tO\namiodarone\tB-Chemical\nwere\tO\ndependent\tO\nupon\tO\nthe\tO\npresence\tO\nof\tO\na\tO\nfunctional\tO\nPPARalpha\tO\ngene\tO\n.\tO\n\nCompared\tO\nto\tO\nwild\tO\n-\tO\ntype\tO\nmice\tO\n,\tO\ntreatment\tO\nof\tO\nPPARalpha\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nwith\tO\namiodarone\tB-Chemical\nresulted\tO\nin\tO\nan\tO\nincreased\tO\nrate\tO\nand\tO\nextent\tO\nof\tO\ntotal\tO\nbody\tO\nweight\tB-Disease\nloss\tI-Disease\n.\tO\n\nThe\tO\ninability\tO\nof\tO\namiodarone\tB-Chemical\nto\tO\ndirectly\tO\nactivate\tO\neither\tO\nhuman\tO\nor\tO\nmouse\tO\nPPARalpha\tO\ntransiently\tO\nexpressed\tO\nin\tO\nhuman\tO\nHepG2\tO\nhepatoma\tB-Disease\ncells\tO\nindicates\tO\nthat\tO\nthe\tO\neffects\tO\nof\tO\namiodarone\tB-Chemical\non\tO\nthe\tO\nfunction\tO\nof\tO\nthis\tO\nreceptor\tO\nwere\tO\nindirect\tO\n.\tO\n\nBased\tO\nupon\tO\nthese\tO\nresults\tO\n,\tO\nwe\tO\nconclude\tO\nthat\tO\namiodarone\tB-Chemical\ndisrupts\tO\nhepatic\tO\nlipid\tO\nhomeostasis\tO\nand\tO\nthat\tO\nthe\tO\nincreased\tO\nexpression\tO\nof\tO\nPPARalpha\tO\ntarget\tO\ngenes\tO\nis\tO\nsecondary\tO\nto\tO\nthis\tO\ntoxic\tO\neffect\tO\n.\tO\n\nThese\tO\nresults\tO\nprovide\tO\nimportant\tO\nnew\tO\nmechanistic\tO\ninformation\tO\nregarding\tO\nthe\tO\nhepatotoxic\tB-Disease\neffects\tO\nof\tO\namiodarone\tB-Chemical\nand\tO\nindicate\tO\nthat\tO\nPPARalpha\tO\nprotects\tO\nagainst\tO\namiodarone\tB-Chemical\n-\tO\ninduced\tO\nhepatotoxicity\tB-Disease\n.\tO\n\nSafety\tO\nand\tO\ncompliance\tO\nwith\tO\nonce\tO\n-\tO\ndaily\tO\nniacin\tB-Chemical\nextended\tI-Chemical\n-\tI-Chemical\nrelease\tI-Chemical\n/\tI-Chemical\nlovastatin\tI-Chemical\nas\tO\ninitial\tO\ntherapy\tO\nin\tO\nthe\tO\nImpact\tO\nof\tO\nMedical\tO\nSubspecialty\tO\non\tO\nPatient\tO\nCompliance\tO\nto\tO\nTreatment\tO\n(\tO\nIMPACT\tO\n)\tO\nstudy\tO\n.\tO\n\nNiacin\tB-Chemical\nextended\tI-Chemical\n-\tI-Chemical\nrelease\tI-Chemical\n/\tI-Chemical\nlovastatin\tI-Chemical\nis\tO\na\tO\nnew\tO\ncombination\tO\nproduct\tO\napproved\tO\nfor\tO\ntreatment\tO\nof\tO\nprimary\tO\nhypercholesterolemia\tB-Disease\nand\tO\nmixed\tO\ndyslipidemia\tB-Disease\n.\tO\n\nThis\tO\nopen\tO\n-\tO\nlabeled\tO\n,\tO\nmulticenter\tO\nstudy\tO\nevaluated\tO\nthe\tO\nsafety\tO\nof\tO\nbedtime\tO\nniacin\tB-Chemical\nextended\tI-Chemical\n-\tI-Chemical\nrelease\tI-Chemical\n/\tI-Chemical\nlovastatin\tI-Chemical\nwhen\tO\ndosed\tO\nas\tO\ninitial\tO\ntherapy\tO\nand\tO\npatient\tO\ncompliance\tO\nto\tO\ntreatment\tO\nin\tO\nvarious\tO\nclinical\tO\npractice\tO\nsettings\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n4\tO\n,\tO\n499\tO\npatients\tO\nwith\tO\ndyslipidemia\tB-Disease\nrequiring\tO\ndrug\tO\nintervention\tO\nwas\tO\nenrolled\tO\nat\tO\n1\tO\n,\tO\n081\tO\nsites\tO\n.\tO\n\nPatients\tO\nwere\tO\ntreated\tO\nwith\tO\n1\tO\ntablet\tO\n(\tO\n500\tO\nmg\tO\nof\tO\nniacin\tB-Chemical\nextended\tO\n-\tO\nrelease\tO\n/\tO\n20\tO\nmg\tO\nof\tO\nlovastatin\tB-Chemical\n)\tO\nonce\tO\nnightly\tO\nfor\tO\n4\tO\nweeks\tO\nand\tO\nthen\tO\n2\tO\ntablets\tO\nfor\tO\n8\tO\nweeks\tO\n.\tO\n\nPatients\tO\nalso\tO\nreceived\tO\ndietary\tO\ncounseling\tO\n,\tO\neducational\tO\nmaterials\tO\n,\tO\nand\tO\nreminders\tO\nto\tO\ncall\tO\na\tO\ntoll\tO\n-\tO\nfree\tO\nnumber\tO\nthat\tO\nprovided\tO\nfurther\tO\neducation\tO\nabout\tO\ndyslipidemia\tB-Disease\nand\tO\nniacin\tB-Chemical\nextended\tI-Chemical\n-\tI-Chemical\nrelease\tI-Chemical\n/\tI-Chemical\nlovastatin\tI-Chemical\n.\tO\n\nPrimary\tO\nend\tO\npoints\tO\nwere\tO\nstudy\tO\ncompliance\tO\n,\tO\nincreases\tO\nin\tO\nliver\tO\ntransaminases\tO\nto\tO\n>\tO\n3\tO\ntimes\tO\nthe\tO\nupper\tO\nlimit\tO\nof\tO\nnormal\tO\n,\tO\nand\tO\nclinical\tO\nmyopathy\tB-Disease\n.\tO\n\nFinal\tO\nstudy\tO\nstatus\tO\nwas\tO\navailable\tO\nfor\tO\n4\tO\n,\tO\n217\tO\npatients\tO\n(\tO\n94\tO\n%\tO\n)\tO\n.\tO\n\nCompliance\tO\nto\tO\nniacin\tB-Chemical\nextended\tI-Chemical\n-\tI-Chemical\nrelease\tI-Chemical\n/\tI-Chemical\nlovastatin\tI-Chemical\nwas\tO\n77\tO\n%\tO\n,\tO\nwith\tO\n3\tO\n,\tO\n245\tO\npatients\tO\ncompleting\tO\nthe\tO\nstudy\tO\n.\tO\n\nPatients\tO\nin\tO\nthe\tO\nsoutheast\tO\nand\tO\nthose\tO\nenrolled\tO\nby\tO\nendocrinologists\tO\nhad\tO\nthe\tO\nlowest\tO\ncompliance\tO\nand\tO\nhighest\tO\nadverse\tO\nevent\tO\nrates\tO\n.\tO\n\nFlushing\tB-Disease\nwas\tO\nthe\tO\nmost\tO\ncommon\tO\nadverse\tO\nevent\tO\n,\tO\nreported\tO\nby\tO\n18\tO\n%\tO\nof\tO\npatients\tO\nand\tO\nleading\tO\nto\tO\ndiscontinuation\tO\nby\tO\n6\tO\n%\tO\n.\tO\n\nIncidence\tO\nof\tO\nincreased\tO\naspartate\tB-Chemical\naminotransferase\tO\nand\tO\n/\tO\nor\tO\nalanine\tB-Chemical\naminotransferase\tO\n>\tO\n3\tO\ntimes\tO\nthe\tO\nupper\tO\nlimit\tO\nof\tO\nnormal\tO\nwas\tO\n<\tO\n0\tO\n.\tO\n3\tO\n%\tO\n.\tO\n\nAn\tO\nincrease\tO\nof\tO\ncreatine\tB-Chemical\nphosphokinase\tO\nto\tO\n>\tO\n5\tO\ntimes\tO\nthe\tO\nupper\tO\nlimit\tO\nof\tO\nnormal\tO\noccurred\tO\nin\tO\n0\tO\n.\tO\n24\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nand\tO\nno\tO\ncases\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nmyopathy\tB-Disease\nwere\tO\nobserved\tO\n.\tO\n\nNiacin\tB-Chemical\nextended\tI-Chemical\n-\tI-Chemical\nrelease\tI-Chemical\n/\tI-Chemical\nlovastatin\tI-Chemical\n1\tO\n,\tO\n000\tO\n/\tO\n40\tO\nmg\tO\n,\tO\ndosed\tO\nas\tO\ninitial\tO\ntherapy\tO\n,\tO\nwas\tO\nassociated\tO\nwith\tO\ngood\tO\ncompliance\tO\nand\tO\nsafety\tO\nand\tO\nhad\tO\nvery\tO\nlow\tO\nincidences\tO\nof\tO\nincreased\tO\nliver\tO\nand\tO\nmuscle\tO\nenzymes\tO\n.\tO\n\nProtective\tO\neffect\tO\nof\tO\nTerminalia\tB-Chemical\nchebula\tI-Chemical\nagainst\tO\nexperimental\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\ninduced\tO\nby\tO\nisoproterenol\tB-Chemical\n.\tO\n\nCardioprotective\tO\neffect\tO\nof\tO\nethanolic\tB-Chemical\nextract\tI-Chemical\nof\tI-Chemical\nTerminalia\tI-Chemical\nchebula\tI-Chemical\nfruits\tI-Chemical\n(\tO\n500\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nwt\tO\n)\tO\nwas\tO\nexamined\tO\nin\tO\nisoproterenol\tB-Chemical\n(\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nwt\tO\n)\tO\ninduced\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nIn\tO\nisoproterenol\tB-Chemical\nadministered\tO\nrats\tO\n,\tO\nthe\tO\nlevel\tO\nof\tO\nlipid\tO\nperoxides\tB-Chemical\nincreased\tO\nsignificantly\tO\nin\tO\nthe\tO\nserum\tO\nand\tO\nheart\tO\n.\tO\n\nA\tO\nsignificant\tO\ndecrease\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\nactivity\tO\nof\tO\nthe\tO\nmyocardial\tO\nmarker\tO\nenzymes\tO\nwith\tO\na\tO\nconcomitant\tO\nincrease\tO\nin\tO\ntheir\tO\nactivity\tO\nin\tO\nserum\tO\n.\tO\n\nHistopathological\tO\nexamination\tO\nwas\tO\ncarried\tO\nout\tO\nto\tO\nconfirm\tO\nthe\tO\nmyocardial\tO\nnecrosis\tB-Disease\n.\tO\n\nT\tB-Chemical\n.\tI-Chemical\nchebula\tI-Chemical\nextract\tI-Chemical\npretreatment\tO\nwas\tO\nfound\tO\nto\tO\nameliorate\tO\nthe\tO\neffect\tO\nof\tO\nisoproterenol\tB-Chemical\non\tO\nlipid\tO\nperoxide\tB-Chemical\nformation\tO\nand\tO\nretained\tO\nthe\tO\nactivities\tO\nof\tO\nthe\tO\ndiagnostic\tO\nmarker\tO\nenzymes\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\npostoperative\tO\nanxiety\tB-Disease\ndue\tO\nto\tO\nlow\tO\ndose\tO\ndroperidol\tB-Chemical\nused\tO\nwith\tO\npatient\tO\n-\tO\ncontrolled\tO\nanalgesia\tO\n.\tO\n\nA\tO\nmultiparous\tO\nwoman\tO\nin\tO\ngood\tO\npsychological\tO\nhealth\tO\nunderwent\tO\nurgent\tO\ncaesarean\tO\nsection\tO\nin\tO\nlabour\tO\n.\tO\n\nPostoperatively\tO\n,\tO\nshe\tO\nwas\tO\ngiven\tO\na\tO\npatient\tO\n-\tO\ncontrolled\tO\nanalgesia\tO\ndevice\tO\ndelivering\tO\nboluses\tO\nof\tO\ndiamorphine\tB-Chemical\n0\tO\n.\tO\n5\tO\nmg\tO\nand\tO\ndroperidol\tB-Chemical\n0\tO\n.\tO\n025\tO\nmg\tO\n.\tO\n\nWhilst\tO\nusing\tO\nthe\tO\ndevice\tO\nshe\tO\ngradually\tO\nbecame\tO\nanxious\tO\n,\tO\nthe\tO\nfeeling\tO\nworsening\tO\nafter\tO\neach\tO\nbolus\tO\n.\tO\n\nThe\tO\ndiagnosis\tO\nof\tO\ndroperidol\tB-Chemical\n-\tO\ninduced\tO\npsychological\tB-Disease\ndisturbance\tI-Disease\nwas\tO\nnot\tO\nmade\tO\nstraight\tO\naway\tO\nalthough\tO\non\tO\nsubsequent\tO\nclose\tO\nquestioning\tO\nthe\tO\npatient\tO\ngave\tO\na\tO\nvery\tO\nclear\tO\nhistory\tO\n.\tO\n\nAfter\tO\nshe\tO\nhad\tO\nreceived\tO\na\tO\ntotal\tO\nof\tO\nonly\tO\n0\tO\n.\tO\n9\tO\nmg\tO\ndroperidol\tB-Chemical\n,\tO\na\tO\nsyringe\tO\ncontaining\tO\ndiamorphine\tB-Chemical\nonly\tO\nwas\tO\nsubstituted\tO\nand\tO\nher\tO\nunease\tO\nresolved\tO\ncompletely\tO\n.\tO\n\nWe\tO\nfeel\tO\nthat\tO\n,\tO\nalthough\tO\nthe\tO\ndramatic\tO\nextrapyramidal\tO\nside\tO\neffects\tO\nof\tO\ndopaminergic\tO\nantiemetics\tO\nare\tO\nwell\tO\nknown\tO\n,\tO\nmore\tO\nsubtle\tO\nmanifestations\tO\nmay\tO\neasily\tO\nbe\tO\noverlooked\tO\n.\tO\n\nAccurate\tO\npatient\tO\nhistory\tO\ncontributes\tO\nto\tO\ndifferentiating\tO\ndiabetes\tB-Disease\ninsipidus\tI-Disease\n:\tO\na\tO\ncase\tO\nstudy\tO\n.\tO\n\nThis\tO\ncase\tO\nstudy\tO\nhighlights\tO\nthe\tO\nimportant\tO\ncontribution\tO\nof\tO\nnursing\tO\nin\tO\nobtaining\tO\nan\tO\naccurate\tO\nhealth\tO\nhistory\tO\n.\tO\n\nThe\tO\ncase\tO\ndiscussed\tO\nherein\tO\ninitially\tO\nappeared\tO\nto\tO\nbe\tO\nneurogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\n(\tO\nDI\tB-Disease\n)\tO\nsecondary\tO\nto\tO\na\tO\ntraumatic\tB-Disease\nbrain\tI-Disease\ninjury\tI-Disease\n.\tO\n\nThe\tO\nnursing\tO\nstaff\tO\n,\tO\nby\tO\nreviewing\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nhealth\tO\nhistory\tO\nwith\tO\nhis\tO\nfamily\tO\n,\tO\ndiscovered\tO\na\tO\nhistory\tO\nof\tO\npolydipsia\tB-Disease\nand\tO\nlong\tO\n-\tO\nstanding\tO\nlithium\tB-Chemical\nuse\tO\n.\tO\n\nLithium\tB-Chemical\nis\tO\nimplicated\tO\nin\tO\ndrug\tO\n-\tO\ninduced\tO\nnephrogenic\tB-Disease\nDI\tI-Disease\n,\tO\nand\tO\nbecause\tO\nthe\tO\npatient\tO\nhad\tO\nnot\tO\nreceived\tO\nlithium\tB-Chemical\nsince\tO\nbeing\tO\nadmitted\tO\nto\tO\nthe\tO\nhospital\tO\n,\tO\nhis\tO\ntreatment\tO\nchanged\tO\nto\tO\nfocus\tO\non\tO\nnephrogenic\tB-Disease\nDI\tI-Disease\n.\tO\n\nBy\tO\ncombining\tO\ninformation\tO\nfrom\tO\nthe\tO\npatient\tO\nhistory\tO\n,\tO\nthe\tO\nphysical\tO\nexamination\tO\n,\tO\nand\tO\nradiologic\tO\nand\tO\nlaboratory\tO\nstudies\tO\n,\tO\nthe\tO\ncritical\tO\ncare\tO\nteam\tO\ndemonstrated\tO\nthat\tO\nthe\tO\npatient\tO\nhad\tO\nbeen\tO\nself\tO\n-\tO\ntreating\tO\nhis\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\nnephrogenic\tB-Disease\nDI\tI-Disease\nand\tO\ndeveloped\tO\nneurogenic\tB-Disease\nDI\tI-Disease\nsecondary\tO\nto\tO\nbrain\tB-Disease\ntrauma\tI-Disease\n.\tO\n\nThus\tO\nsuccessful\tO\ntreatment\tO\nrequired\tO\nthat\tO\nnephrogenic\tO\nand\tO\nneurogenic\tB-Disease\nDI\tI-Disease\nbe\tO\ntreated\tO\nconcomitantly\tO\n.\tO\n\nFactors\tO\ncontributing\tO\nto\tO\nribavirin\tB-Chemical\n-\tO\ninduced\tO\nanemia\tB-Disease\n.\tO\n\nBACKGROUND\tO\nAND\tO\nAIM\tO\n:\tO\nInterferon\tB-Chemical\nand\tO\nribavirin\tB-Chemical\ncombination\tO\ntherapy\tO\nfor\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nC\tI-Disease\nproduces\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nconducted\tO\nto\tO\nidentify\tO\nthe\tO\nfactors\tO\ncontributing\tO\nto\tO\nribavirin\tB-Chemical\n-\tO\ninduced\tO\nanemia\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nEighty\tO\n-\tO\neight\tO\npatients\tO\nwith\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nC\tI-Disease\nwho\tO\nreceived\tO\ninterferon\tB-Chemical\n-\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\n2b\tI-Chemical\nat\tO\na\tO\ndose\tO\nof\tO\n6\tO\nMU\tO\nadministered\tO\nintramuscularly\tO\nfor\tO\n24\tO\nweeks\tO\nin\tO\ncombination\tO\nwith\tO\nribavirin\tB-Chemical\nadministered\tO\norally\tO\nat\tO\na\tO\ndose\tO\nof\tO\n600\tO\nmg\tO\nor\tO\n800\tO\nmg\tO\nparticipated\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nA\tO\nhemoglobin\tO\nconcentration\tO\nof\tO\n<\tO\n10\tO\ng\tO\n/\tO\ndL\tO\nwas\tO\ndefined\tO\nas\tO\nribavirin\tB-Chemical\n-\tO\ninduced\tO\nanemia\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nRibavirin\tB-Chemical\n-\tO\ninduced\tO\nanemia\tB-Disease\noccurred\tO\nin\tO\n18\tO\n(\tO\n20\tO\n.\tO\n5\tO\n%\tO\n)\tO\npatients\tO\nduring\tO\ntreatment\tO\n.\tO\n\nA\tO\n2\tO\ng\tO\n/\tO\ndL\tO\ndecrease\tO\nin\tO\nhemoglobin\tO\nconcentrations\tO\nin\tO\npatients\tO\nwith\tO\nanemia\tB-Disease\nwas\tO\nobserved\tO\nat\tO\nweek\tO\n2\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\ntreatment\tO\n.\tO\n\nThe\tO\nhemoglobin\tO\nconcentration\tO\nin\tO\npatients\tO\nwith\tO\n>\tO\nor\tO\n=\tO\n2\tO\ng\tO\n/\tO\ndL\tO\ndecrease\tO\nat\tO\nweek\tO\n2\tO\nwas\tO\nobserved\tO\nto\tO\nbe\tO\nsignificantly\tO\nlower\tO\neven\tO\nafter\tO\nweek\tO\n2\tO\nthan\tO\nin\tO\npatients\tO\nwith\tO\n<\tO\n2\tO\ng\tO\n/\tO\ndL\tO\ndecrease\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nA\tO\nsignificant\tO\nrelationship\tO\nwas\tO\nobserved\tO\nbetween\tO\nthe\tO\nrate\tO\nof\tO\nreduction\tO\nof\tO\nhemoglobin\tO\nconcentrations\tO\nat\tO\nweek\tO\n2\tO\nand\tO\nthe\tO\nseverity\tO\nof\tO\nanemia\tB-Disease\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nSuch\tO\nfactors\tO\nas\tO\nsex\tO\n(\tO\nfemale\tO\n)\tO\n,\tO\nage\tO\n(\tO\n>\tO\nor\tO\n=\tO\n60\tO\nyears\tO\nold\tO\n)\tO\n,\tO\nand\tO\nthe\tO\nribavirin\tB-Chemical\ndose\tO\nby\tO\nbody\tO\nweight\tO\n(\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nor\tO\nmore\tO\n)\tO\nwere\tO\nsignificant\tO\nby\tO\nunivariate\tO\nanalysis\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCareful\tO\nadministration\tO\nis\tO\nnecessary\tO\nin\tO\npatients\tO\n>\tO\nor\tO\n=\tO\n60\tO\nyears\tO\nold\tO\n,\tO\nin\tO\nfemale\tO\npatients\tO\n,\tO\nand\tO\nin\tO\npatients\tO\nreceiving\tO\na\tO\nribavirin\tB-Chemical\ndose\tO\nof\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nor\tO\nmore\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperience\tO\na\tO\nfall\tO\nin\tO\nhemoglobin\tO\nconcentrations\tO\nof\tO\n2\tO\ng\tO\n/\tO\ndL\tO\nor\tO\nmore\tO\nat\tO\nweek\tO\n2\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\ntreatment\tO\nshould\tO\nbe\tO\nmonitored\tO\nwith\tO\nparticular\tO\ncare\tO\n.\tO\n\nZidovudine\tB-Chemical\n-\tO\ninduced\tO\nhepatitis\tB-Disease\n.\tO\n\nA\tO\ncase\tO\nof\tO\nacute\tO\nhepatitis\tB-Disease\ninduced\tO\nby\tO\nzidovudine\tB-Chemical\nin\tO\na\tO\n38\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\nwith\tO\nAIDS\tB-Disease\nis\tO\npresented\tO\n.\tO\n\nThe\tO\nmechanism\tO\nwhereby\tO\nthe\tO\nhepatitis\tB-Disease\nwas\tO\ninduced\tO\nis\tO\nnot\tO\nknown\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\npatient\tO\ntolerated\tO\nwell\tO\nan\tO\nalternative\tO\nreverse\tO\ntranscriptase\tO\ninhibitor\tO\n,\tO\n2\tB-Chemical\n'\tI-Chemical\n3\tI-Chemical\n'\tI-Chemical\ndideoxyinosine\tI-Chemical\n.\tO\n\nPhysicians\tO\ncaring\tO\nfor\tO\npatients\tO\nwith\tO\nAIDS\tB-Disease\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\nhitherto\tO\nrarely\tO\nreported\tO\ncomplication\tO\n.\tO\n\nOxidative\tO\ndamage\tO\nprecedes\tO\nnitrative\tO\ndamage\tO\nin\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tO\nmitochondrial\tB-Disease\ninjury\tI-Disease\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nif\tO\nelevated\tO\nreactive\tO\noxygen\tB-Chemical\n(\tO\nROS\tO\n)\tO\n/\tO\nnitrogen\tB-Chemical\nspecies\tO\n(\tO\nRNS\tO\n)\tO\nreported\tO\nto\tO\nbe\tO\npresent\tO\nin\tO\nadriamycin\tB-Chemical\n(\tO\nADR\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nactually\tO\nresulted\tO\nin\tO\ncardiomyocyte\tO\noxidative\tO\n/\tO\nnitrative\tO\ndamage\tO\n,\tO\nand\tO\nto\tO\nquantitatively\tO\ndetermine\tO\nthe\tO\ntime\tO\ncourse\tO\nand\tO\nsubcellular\tO\nlocalization\tO\nof\tO\nthese\tO\npostulated\tO\ndamage\tO\nproducts\tO\nusing\tO\nan\tO\nin\tO\nvivo\tO\napproach\tO\n.\tO\n\nB6C3\tO\nmice\tO\nwere\tO\ntreated\tO\nwith\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\nADR\tB-Chemical\n.\tO\n\nUltrastructural\tO\ndamage\tO\nand\tO\nlevels\tO\nof\tO\n4\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nnonenal\tI-Chemical\n(\tO\n4HNE\tB-Chemical\n)\tO\n-\tO\nprotein\tO\nadducts\tO\nand\tO\n3\tB-Chemical\n-\tI-Chemical\nnitrotyrosine\tI-Chemical\n(\tO\n3NT\tB-Chemical\n)\tO\nwere\tO\nanalyzed\tO\n.\tO\n\nQuantitative\tO\nultrastructural\tO\ndamage\tO\nusing\tO\ncomputerized\tO\nimage\tO\ntechniques\tO\nshowed\tO\ncardiomyocyte\tO\ninjury\tO\nas\tO\nearly\tO\nas\tO\n3\tO\nhours\tO\n,\tO\nwith\tO\nmitochondria\tO\nbeing\tO\nthe\tO\nmost\tO\nextensively\tO\nand\tO\nprogressively\tO\ninjured\tO\nsubcellular\tO\norganelle\tO\n.\tO\n\nAnalysis\tO\nof\tO\n4HNE\tB-Chemical\nprotein\tO\nadducts\tO\nby\tO\nimmunogold\tO\nelectron\tO\nmicroscopy\tO\nshowed\tO\nappearance\tO\nof\tO\n4HNE\tB-Chemical\nprotein\tO\nadducts\tO\nin\tO\nmitochondria\tO\nas\tO\nearly\tO\nas\tO\n3\tO\nhours\tO\n,\tO\nwith\tO\na\tO\npeak\tO\nat\tO\n6\tO\nhours\tO\nand\tO\nsubsequent\tO\ndecline\tO\nat\tO\n24\tO\nhours\tO\n.\tO\n\n3NT\tB-Chemical\nlevels\tO\nwere\tO\nsignificantly\tO\nincreased\tO\nin\tO\nall\tO\nsubcellular\tO\ncompartments\tO\nat\tO\n6\tO\nhours\tO\nand\tO\nsubsequently\tO\ndeclined\tO\nat\tO\n24\tO\nhours\tO\n.\tO\n\nOur\tO\ndata\tO\nshowed\tO\nADR\tB-Chemical\ninduced\tO\n4HNE\tB-Chemical\n-\tO\nprotein\tO\nadducts\tO\nin\tO\nmitochondria\tO\nat\tO\nthe\tO\nsame\tO\ntime\tO\npoint\tO\nas\tO\nwhen\tO\nmitochondrial\tB-Disease\ninjury\tI-Disease\ninitially\tO\nappeared\tO\n.\tO\n\nThese\tO\nresults\tO\ndocument\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nvivo\tO\nthat\tO\nmitochondrial\tB-Disease\noxidative\tI-Disease\ndamage\tI-Disease\nprecedes\tO\nnitrative\tO\ndamage\tO\n.\tO\n\nThe\tO\nprogressive\tO\nnature\tO\nof\tO\nmitochondrial\tB-Disease\ninjury\tI-Disease\nsuggests\tO\nthat\tO\nmitochondria\tO\n,\tO\nnot\tO\nother\tO\nsubcellular\tO\norganelles\tO\n,\tO\nare\tO\nthe\tO\nmajor\tO\nsite\tO\nof\tO\nintracellular\tO\ninjury\tO\n.\tO\n\nSotalol\tB-Chemical\n-\tO\ninduced\tO\ncoronary\tB-Disease\nspasm\tI-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\ndilated\tB-Disease\ncardiomyopathy\tI-Disease\nassociated\tO\nwith\tO\nsustained\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n.\tO\n\nA\tO\n54\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nsevere\tO\nleft\tO\nventricular\tB-Disease\ndysfunction\tI-Disease\ndue\tO\nto\tO\ndilated\tB-Disease\ncardiomyopathy\tI-Disease\nwas\tO\nreferred\tO\nto\tO\nour\tO\nhospital\tO\nfor\tO\nsymptomatic\tO\nincessant\tO\nsustained\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n(\tO\nVT\tB-Disease\n)\tO\n.\tO\n\nAfter\tO\nthe\tO\nadministration\tO\nof\tO\nnifekalant\tB-Chemical\nhydrochloride\tI-Chemical\n,\tO\nsustained\tO\nVT\tB-Disease\nwas\tO\nterminated\tO\n.\tO\n\nAn\tO\nalternate\tO\nclass\tO\nIII\tO\nagent\tO\n,\tO\nsotalol\tB-Chemical\n,\tO\nwas\tO\nalso\tO\neffective\tO\nfor\tO\nthe\tO\nprevention\tO\nof\tO\nVT\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\none\tO\nmonth\tO\nafter\tO\nswitching\tO\nover\tO\nnifekalant\tB-Chemical\nto\tO\nsotalol\tB-Chemical\n,\tO\na\tO\nshort\tO\nduration\tO\nof\tO\nST\tO\nelevation\tO\nwas\tO\ndocumented\tO\nin\tO\nECG\tO\nmonitoring\tO\nat\tO\nalmost\tO\nthe\tO\nsame\tO\ntime\tO\nfor\tO\nthree\tO\nconsecutive\tO\ndays\tO\n.\tO\n\nST\tO\nelevation\tO\nwith\tO\nchest\tO\ndiscomfort\tO\ndisappeared\tO\nsince\tO\nhe\tO\nbegan\tO\ntaking\tO\nlong\tO\n-\tO\nacting\tO\ndiltiazem\tB-Chemical\n.\tO\n\nCoronary\tB-Disease\nvasospasm\tI-Disease\nmay\tO\nbe\tO\ninduced\tO\nby\tO\nthe\tO\nnon\tO\n-\tO\nselective\tO\nbeta\tO\n-\tO\nblocking\tO\nproperties\tO\nof\tO\nsotalol\tB-Chemical\n.\tO\n\nEffects\tO\nof\tO\nthe\tO\nantidepressant\tO\ntrazodone\tB-Chemical\n,\tO\na\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n2A\tO\n/\tO\n2C\tO\nreceptor\tO\nantagonist\tO\n,\tO\non\tO\ndopamine\tB-Chemical\n-\tO\ndependent\tO\nbehaviors\tO\nin\tO\nrats\tO\n.\tO\n\nRATIONALE\tO\n:\tO\n5\tB-Chemical\n-\tI-Chemical\nHydroxytryptamine\tI-Chemical\n,\tO\nvia\tO\nstimulation\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n2C\tO\nreceptors\tO\n,\tO\nexerts\tO\na\tO\ntonic\tO\ninhibitory\tO\ninfluence\tO\non\tO\ndopaminergic\tO\nneurotransmission\tO\n,\tO\nwhereas\tO\nactivation\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n2A\tO\nreceptors\tO\nenhances\tO\nstimulated\tO\nDAergic\tO\nneurotransmission\tO\n.\tO\n\nThe\tO\nantidepressant\tO\ntrazodone\tB-Chemical\nis\tO\na\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n2A\tO\n/\tO\n2C\tO\nreceptor\tO\nantagonist\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\neffect\tO\nof\tO\ntrazodone\tB-Chemical\ntreatment\tO\non\tO\nbehaviors\tO\ndependent\tO\non\tO\nthe\tO\nfunctional\tO\nstatus\tO\nof\tO\nthe\tO\nnigrostriatal\tO\nDAergic\tO\nsystem\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\neffect\tO\nof\tO\npretreatment\tO\nwith\tO\ntrazodone\tB-Chemical\non\tO\ndexamphetamine\tB-Chemical\n-\tO\nand\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\noral\tB-Disease\nstereotypies\tI-Disease\n,\tO\non\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\nand\tO\napomorphine\tB-Chemical\n(\tO\n0\tO\n.\tO\n05\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\non\tO\nergometrine\tB-Chemical\n-\tO\ninduced\tO\nwet\tO\ndog\tO\nshake\tO\n(\tO\nWDS\tO\n)\tO\nbehavior\tO\nand\tO\nfluoxetine\tB-Chemical\n-\tO\ninduced\tO\npenile\tO\nerections\tO\nwas\tO\nstudied\tO\nin\tO\nrats\tO\n.\tO\n\nWe\tO\nalso\tO\ninvestigated\tO\nwhether\tO\ntrazodone\tB-Chemical\ninduces\tO\ncatalepsy\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTrazodone\tB-Chemical\nat\tO\n2\tO\n.\tO\n5\tO\n-\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\ndid\tO\nnot\tO\ninduce\tO\ncatalepsy\tB-Disease\n,\tO\nand\tO\ndid\tO\nnot\tO\nantagonize\tO\napomorphine\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nand\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nstereotypy\tO\nand\tO\napomorphine\tB-Chemical\n(\tO\n0\tO\n.\tO\n05\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\npretreatment\tO\nwith\tO\n5\tO\n,\tO\n10\tO\nand\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\ntrazodone\tB-Chemical\nenhanced\tO\ndexamphetamine\tB-Chemical\nstereotypy\tO\n,\tO\nand\tO\nantagonized\tO\nhaloperidol\tB-Chemical\ncatalepsy\tB-Disease\n,\tO\nergometrine\tB-Chemical\n-\tO\ninduced\tO\nWDS\tO\nbehavior\tO\nand\tO\nfluoxetine\tB-Chemical\n-\tO\ninduced\tO\npenile\tO\nerections\tO\n.\tO\n\nTrazodone\tB-Chemical\nat\tO\n30\tO\n,\tO\n40\tO\nand\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\ninduced\tO\ncatalepsy\tB-Disease\nand\tO\nantagonized\tO\napomorphine\tB-Chemical\nand\tO\ndexamphetamine\tB-Chemical\nstereotypies\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nOur\tO\nresults\tO\nindicate\tO\nthat\tO\ntrazodone\tB-Chemical\nat\tO\n2\tO\n.\tO\n5\tO\n-\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ndoes\tO\nnot\tO\nblock\tO\npre\tO\n-\tO\nand\tO\npostsynaptic\tO\nstriatal\tO\nD2\tO\nDA\tO\nreceptors\tO\n,\tO\nwhile\tO\nat\tO\n30\tO\n,\tO\n40\tO\nand\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nit\tO\nblocks\tO\npostsynaptic\tO\nstriatal\tO\nD2\tO\nDA\tO\nreceptors\tO\n.\tO\n\nFurthermore\tO\n,\tO\nat\tO\n5\tO\n,\tO\n10\tO\nand\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ntrazodone\tB-Chemical\nblocks\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n2A\tO\nand\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n2C\tO\nreceptors\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\ntrazodone\tB-Chemical\n(\tO\n5\tO\n,\tO\n10\tO\nand\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nby\tO\nblocking\tO\nthe\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n2C\tO\nreceptors\tO\n,\tO\nreleases\tO\nthe\tO\nnigrostriatal\tO\nDAergic\tO\nneurons\tO\nfrom\tO\ntonic\tO\ninhibition\tO\ncaused\tO\nby\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n,\tO\nand\tO\nthereby\tO\npotentiates\tO\ndexamphetamine\tB-Chemical\nstereotypy\tO\nand\tO\nantagonizes\tO\nhaloperidol\tB-Chemical\ncatalepsy\tB-Disease\n.\tO\n\nSwallowing\tB-Disease\nabnormalities\tI-Disease\nand\tO\ndyskinesia\tB-Disease\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nGastrointestinal\tB-Disease\nabnormalities\tI-Disease\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\nhave\tO\nbeen\tO\nknown\tO\nfor\tO\nalmost\tO\ntwo\tO\ncenturies\tO\n,\tO\nbut\tO\nmany\tO\naspects\tO\nconcerning\tO\ntheir\tO\npathophysiology\tO\nhave\tO\nnot\tO\nbeen\tO\ncompletely\tO\nclarified\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ncharacterize\tO\nthe\tO\noropharyngeal\tO\ndynamics\tO\nin\tO\nPD\tB-Disease\npatients\tO\nwith\tO\nand\tO\nwithout\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\n.\tO\n\nFifteen\tO\ndyskinetic\tB-Disease\n,\tO\n12\tO\nnondyskinetic\tO\npatients\tO\n,\tO\nand\tO\na\tO\ncontrol\tO\ngroup\tO\nwere\tO\nincluded\tO\n.\tO\n\nPatients\tO\nwere\tO\nasked\tO\nabout\tO\ndysphagia\tB-Disease\nand\tO\nevaluated\tO\nwith\tO\nthe\tO\nUnified\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nRating\tO\nScale\tO\nParts\tO\nII\tO\nand\tO\nIII\tO\nand\tO\nthe\tO\nHoehn\tO\nand\tO\nYahr\tO\nscale\tO\n.\tO\n\nDeglutition\tO\nwas\tO\nassessed\tO\nusing\tO\nmodified\tO\nbarium\tB-Chemical\nswallow\tO\nwith\tO\nvideofluoroscopy\tO\n.\tO\n\nNondyskinetic\tO\npatients\tO\n,\tO\nbut\tO\nnot\tO\nthe\tO\ndyskinetic\tB-Disease\nones\tO\n,\tO\nshowed\tO\nless\tO\noropharyngeal\tO\nswallowing\tO\nefficiency\tO\n(\tO\nOPSE\tO\n)\tO\nfor\tO\nliquid\tO\nfood\tO\nthan\tO\ncontrols\tO\n(\tO\nDunnett\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nDyskinetic\tB-Disease\npatients\tO\ntended\tO\nto\tO\nhave\tO\na\tO\ngreater\tO\nOPSE\tO\nthan\tO\nnondyskinetic\tO\n(\tO\nDunnett\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n06\tO\n)\tO\n.\tO\n\nPatients\tO\nwho\tO\nwere\tO\nusing\tO\na\tO\nhigher\tO\ndose\tO\nof\tO\nlevodopa\tB-Chemical\nhad\tO\na\tO\ngreater\tO\nOPSE\tO\nand\tO\na\tO\ntrend\tO\ntoward\tO\na\tO\nsmaller\tO\noral\tO\ntransit\tO\ntime\tO\n(\tO\nPearson\tO\n'\tO\ns\tO\ncorrelation\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n01\tO\nand\tO\n0\tO\n.\tO\n08\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nNeither\tO\nthe\tO\nreport\tO\nof\tO\ndysphagia\tB-Disease\nnor\tO\nany\tO\nof\tO\nthe\tO\nPD\tB-Disease\nseverity\tO\nparameters\tO\ncorrelated\tO\nto\tO\nthe\tO\nvideofluoroscopic\tO\nvariables\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\n,\tO\ndyskinetic\tB-Disease\npatients\tO\nperformed\tO\nbetter\tO\nin\tO\nswallowing\tO\nfunction\tO\n,\tO\nwhich\tO\ncould\tO\nbe\tO\nexplained\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\na\tO\ngreater\tO\nlevodopa\tB-Chemical\ndose\tO\n.\tO\n\nOur\tO\nresults\tO\nsuggest\tO\na\tO\nrole\tO\nfor\tO\nlevodopa\tB-Chemical\nin\tO\nthe\tO\noral\tO\nphase\tO\nof\tO\ndeglutition\tO\nand\tO\nconfirm\tO\nthat\tO\ndysphagia\tB-Disease\nis\tO\nnot\tO\na\tO\ngood\tO\npredictor\tO\nof\tO\ndeglutition\tO\nalterations\tO\nin\tO\nPD\tB-Disease\n.\tO\n\nInhibition\tO\nof\tO\nnuclear\tO\nfactor\tO\n-\tO\nkappaB\tO\nactivation\tO\nattenuates\tO\ntubulointerstitial\tB-Disease\nnephritis\tI-Disease\ninduced\tO\nby\tO\ngentamicin\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nAnimals\tO\ntreated\tO\nwith\tO\ngentamicin\tB-Chemical\ncan\tO\nshow\tO\nresidual\tO\nareas\tO\nof\tO\ninterstitial\tO\nfibrosis\tB-Disease\nin\tO\nthe\tO\nrenal\tO\ncortex\tO\n.\tO\n\nThis\tO\nstudy\tO\ninvestigated\tO\nthe\tO\nexpression\tO\nof\tO\nnuclear\tO\nfactor\tO\n-\tO\nkappaB\tO\n(\tO\nNF\tO\n-\tO\nkappaB\tO\n)\tO\n,\tO\nmitogen\tO\n-\tO\nactivated\tO\nprotein\tO\n(\tO\nMAP\tO\n)\tO\nkinases\tO\nand\tO\nmacrophages\tO\nin\tO\nthe\tO\nrenal\tO\ncortex\tO\nand\tO\nstructural\tO\nand\tO\nfunctional\tO\nrenal\tO\nchanges\tO\nof\tO\nrats\tO\ntreated\tO\nwith\tO\ngentamicin\tB-Chemical\nor\tO\ngentamicin\tB-Chemical\n+\tO\npyrrolidine\tB-Chemical\ndithiocarbamate\tI-Chemical\n(\tO\nPDTC\tB-Chemical\n)\tO\n,\tO\nan\tO\nNF\tO\n-\tO\nkappaB\tO\ninhibitor\tO\n.\tO\n\nMETHODS\tO\n:\tO\n38\tO\nfemale\tO\nWistar\tO\nrats\tO\nwere\tO\ninjected\tO\nwith\tO\ngentamicin\tB-Chemical\n,\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ntwice\tO\na\tO\nday\tO\nfor\tO\n9\tO\ndays\tO\n,\tO\n38\tO\nwith\tO\ngentamicin\tB-Chemical\n+\tO\nPDTC\tB-Chemical\n,\tO\nand\tO\n28\tO\nwith\tO\n0\tO\n.\tO\n15\tO\nM\tO\nNaCl\tB-Chemical\nsolution\tO\n.\tO\n\nThe\tO\nanimals\tO\nwere\tO\nkilled\tO\n5\tO\nand\tO\n30\tO\ndays\tO\nafter\tO\nthese\tO\ninjections\tO\nand\tO\nthe\tO\nkidneys\tO\nwere\tO\nremoved\tO\nfor\tO\nhistological\tO\nand\tO\nimmunohistochemical\tO\nstudies\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthe\tO\nimmunohistochemical\tO\nstudies\tO\nwere\tO\nscored\tO\naccording\tO\nto\tO\nthe\tO\nextent\tO\nof\tO\nstaining\tO\n.\tO\n\nThe\tO\nfractional\tO\ninterstitial\tO\narea\tO\nwas\tO\ndetermined\tO\nby\tO\nmorphometry\tO\n.\tO\n\nRESULTS\tO\n:\tO\nGentamicin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\npresented\tO\na\tO\ntransitory\tO\nincrease\tO\nin\tO\nplasma\tO\ncreatinine\tB-Chemical\nlevels\tO\n.\tO\n\nIncreased\tO\nED\tO\n-\tO\n1\tO\n,\tO\nMAP\tO\nkinases\tO\nand\tO\nNF\tO\n-\tO\nkappaB\tO\nstaining\tO\nwere\tO\nalso\tO\nobserved\tO\nin\tO\nthe\tO\nrenal\tO\ncortex\tO\nfrom\tO\nall\tO\ngentamicin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\ncompared\tO\nto\tO\ncontrol\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\nanimals\tO\nkilled\tO\non\tO\nday\tO\n30\tO\nalso\tO\npresented\tO\nfibrosis\tB-Disease\nin\tO\nthe\tO\nrenal\tO\ncortex\tO\ndespite\tO\nthe\tO\nrecovery\tO\nof\tO\nrenal\tO\nfunction\tO\n.\tO\n\nTreatment\tO\nwith\tO\nPDTC\tB-Chemical\nreduced\tO\nthe\tO\nfunctional\tO\nand\tO\nstructural\tO\nchanges\tO\ninduced\tO\nby\tO\ngentamicin\tB-Chemical\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\ndata\tO\nshow\tO\nthat\tO\ninhibition\tO\nof\tO\nNF\tO\n-\tO\nkappaB\tO\nactivation\tO\nattenuates\tO\ntubulointerstitial\tB-Disease\nnephritis\tI-Disease\ninduced\tO\nby\tO\ngentamicin\tB-Chemical\n.\tO\n\nGlucose\tB-Chemical\nmetabolism\tO\nin\tO\npatients\tO\nwith\tO\nschizophrenia\tB-Disease\ntreated\tO\nwith\tO\natypical\tO\nantipsychotic\tO\nagents\tO\n:\tO\na\tO\nfrequently\tO\nsampled\tO\nintravenous\tO\nglucose\tB-Chemical\ntolerance\tO\ntest\tO\nand\tO\nminimal\tO\nmodel\tO\nanalysis\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nWhile\tO\nthe\tO\nincidence\tO\nof\tO\nnew\tO\n-\tO\nonset\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\nmay\tO\nbe\tO\nincreasing\tO\nin\tO\npatients\tO\nwith\tO\nschizophrenia\tB-Disease\ntreated\tO\nwith\tO\ncertain\tO\natypical\tO\nantipsychotic\tO\nagents\tO\n,\tO\nit\tO\nremains\tO\nunclear\tO\nwhether\tO\natypical\tO\nagents\tO\nare\tO\ndirectly\tO\naffecting\tO\nglucose\tB-Chemical\nmetabolism\tO\nor\tO\nsimply\tO\nincreasing\tO\nknown\tO\nrisk\tO\nfactors\tO\nfor\tO\ndiabetes\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nstudy\tO\nthe\tO\n2\tO\ndrugs\tO\nmost\tO\nclearly\tO\nimplicated\tO\n(\tO\nclozapine\tB-Chemical\nand\tO\nolanzapine\tB-Chemical\n)\tO\nand\tO\nrisperidone\tB-Chemical\nusing\tO\na\tO\nfrequently\tO\nsampled\tO\nintravenous\tO\nglucose\tB-Chemical\ntolerance\tO\ntest\tO\n.\tO\n\nDESIGN\tO\n:\tO\nA\tO\ncross\tO\n-\tO\nsectional\tO\ndesign\tO\nin\tO\nstable\tO\n,\tO\ntreated\tO\npatients\tO\nwith\tO\nschizophrenia\tB-Disease\nevaluated\tO\nusing\tO\na\tO\nfrequently\tO\nsampled\tO\nintravenous\tO\nglucose\tB-Chemical\ntolerance\tO\ntest\tO\nand\tO\nthe\tO\nBergman\tO\nminimal\tO\nmodel\tO\nanalysis\tO\n.\tO\n\nSETTING\tO\n:\tO\nSubjects\tO\nwere\tO\nrecruited\tO\nfrom\tO\nan\tO\nurban\tO\ncommunity\tO\nmental\tO\nhealth\tO\nclinic\tO\nand\tO\nwere\tO\nstudied\tO\nat\tO\na\tO\ngeneral\tO\nclinical\tO\nresearch\tO\ncenter\tO\n.\tO\n\nPatients\tO\nFifty\tO\nsubjects\tO\nsigned\tO\ninformed\tO\nconsent\tO\nand\tO\n41\tO\nunderwent\tO\nthe\tO\nfrequently\tO\nsampled\tO\nintravenous\tO\nglucose\tB-Chemical\ntolerance\tO\ntest\tO\n.\tO\n\nThirty\tO\n-\tO\nsix\tO\nnonobese\tO\nsubjects\tO\nwith\tO\nschizophrenia\tB-Disease\nor\tO\nschizoaffective\tB-Disease\ndisorder\tI-Disease\n,\tO\nmatched\tO\nby\tO\nbody\tO\nmass\tO\nindex\tO\nand\tO\ntreated\tO\nwith\tO\neither\tO\nclozapine\tB-Chemical\n,\tO\nolanzapine\tB-Chemical\n,\tO\nor\tO\nrisperidone\tB-Chemical\n,\tO\nwere\tO\nincluded\tO\nin\tO\nthe\tO\nanalysis\tO\n.\tO\n\nMAIN\tO\nOUTCOME\tO\nMEASURES\tO\n:\tO\nFasting\tO\nplasma\tO\nglucose\tB-Chemical\nand\tO\nfasting\tO\nserum\tO\ninsulin\tO\nlevels\tO\n,\tO\ninsulin\tB-Disease\nsensitivity\tI-Disease\nindex\tO\n,\tO\nhomeostasis\tO\nmodel\tO\nassessment\tO\nof\tO\ninsulin\tB-Disease\nresistance\tI-Disease\n,\tO\nand\tO\nglucose\tB-Chemical\neffectiveness\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\nduration\tO\nof\tO\ntreatment\tO\nwith\tO\nthe\tO\nidentified\tO\natypical\tO\nantipsychotic\tO\nagent\tO\nwas\tO\n68\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n28\tO\n.\tO\n9\tO\nmonths\tO\n(\tO\nclozapine\tB-Chemical\n)\tO\n,\tO\n29\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n17\tO\n.\tO\n5\tO\nmonths\tO\n(\tO\nolanzapine\tB-Chemical\n)\tO\n,\tO\nand\tO\n40\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n33\tO\n.\tO\n7\tO\n(\tO\nrisperidone\tB-Chemical\n)\tO\n.\tO\n\nFasting\tO\nserum\tO\ninsulin\tO\nconcentrations\tO\ndiffered\tO\namong\tO\ngroups\tO\n(\tO\nF\tO\n(\tO\n33\tO\n)\tO\n=\tO\n3\tO\n.\tO\n35\tO\n;\tO\nP\tO\n=\tO\n.\tO\n047\tO\n)\tO\n(\tO\nclozapine\tB-Chemical\n>\tO\nolanzapine\tB-Chemical\n>\tO\nrisperidone\tB-Chemical\n)\tO\nwith\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\nclozapine\tB-Chemical\nand\tO\nrisperidone\tB-Chemical\n(\tO\nt\tO\n(\tO\n33\tO\n)\tO\n=\tO\n2\tO\n.\tO\n32\tO\n;\tO\nP\tO\n=\tO\n.\tO\n03\tO\n)\tO\nand\tO\nolanzapine\tB-Chemical\nand\tO\nrisperidone\tB-Chemical\n(\tO\nt\tO\n(\tO\n33\tO\n)\tO\n=\tO\n2\tO\n.\tO\n15\tO\n;\tO\nP\tO\n=\tO\n.\tO\n04\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\ndifference\tO\nin\tO\ninsulin\tB-Disease\nsensitivity\tI-Disease\nindex\tO\namong\tO\ngroups\tO\n(\tO\nF\tO\n(\tO\n33\tO\n)\tO\n=\tO\n10\tO\n.\tO\n66\tO\n;\tO\nP\tO\n<\tO\n.\tO\n001\tO\n)\tO\n(\tO\nclozapine\tB-Chemical\n<\tO\nolanzapine\tB-Chemical\n<\tO\nrisperidone\tB-Chemical\n)\tO\n,\tO\nwith\tO\nsubjects\tO\nwho\tO\nreceived\tO\nclozapine\tB-Chemical\nand\tO\nolanzapine\tB-Chemical\nexhibiting\tO\nsignificant\tO\ninsulin\tB-Disease\nresistance\tI-Disease\ncompared\tO\nwith\tO\nsubjects\tO\nwho\tO\nwere\tO\ntreated\tO\nwith\tO\nrisperidone\tB-Chemical\n(\tO\nclozapine\tB-Chemical\nvs\tO\nrisperidone\tB-Chemical\n,\tO\nt\tO\n(\tO\n33\tO\n)\tO\n=\tO\n-\tO\n4\tO\n.\tO\n29\tO\n;\tO\nP\tO\n<\tO\n.\tO\n001\tO\n;\tO\nolanzapine\tB-Chemical\nvs\tO\nrisperidone\tB-Chemical\n,\tO\nt\tO\n(\tO\n33\tO\n)\tO\n=\tO\n-\tO\n3\tO\n.\tO\n62\tO\n;\tO\nP\tO\n=\tO\n.\tO\n001\tO\n[\tO\nP\tO\n<\tO\n.\tO\n001\tO\n]\tO\n)\tO\n.\tO\n\nThe\tO\nhomeostasis\tO\nmodel\tO\nassessment\tO\nof\tO\ninsulin\tB-Disease\nresistance\tI-Disease\nalso\tO\ndiffered\tO\nsignificantly\tO\namong\tO\ngroups\tO\n(\tO\nF\tO\n(\tO\n33\tO\n)\tO\n=\tO\n4\tO\n.\tO\n92\tO\n;\tO\nP\tO\n=\tO\n.\tO\n01\tO\n)\tO\n(\tO\nclozapine\tB-Chemical\n>\tO\nolanzapine\tB-Chemical\n>\tO\nrisperidone\tB-Chemical\n)\tO\n(\tO\nclozapine\tB-Chemical\nvs\tO\nrisperidone\tB-Chemical\n,\tO\nt\tO\n(\tO\n33\tO\n)\tO\n=\tO\n2\tO\n.\tO\n94\tO\n;\tO\nP\tO\n=\tO\n.\tO\n006\tO\n;\tO\nolanzapine\tB-Chemical\nvs\tO\nrisperidone\tB-Chemical\n,\tO\nt\tO\n(\tO\n33\tO\n)\tO\n=\tO\n2\tO\n.\tO\n42\tO\n;\tO\nP\tO\n=\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\ndifference\tO\namong\tO\ngroups\tO\nin\tO\nglucose\tB-Chemical\neffectiveness\tO\n(\tO\nF\tO\n(\tO\n30\tO\n)\tO\n=\tO\n4\tO\n.\tO\n18\tO\n;\tO\nP\tO\n=\tO\n.\tO\n02\tO\n)\tO\n(\tO\nclozapine\tB-Chemical\n<\tO\nolanzapine\tB-Chemical\n<\tO\nrisperidone\tB-Chemical\n)\tO\nwith\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\nclozapine\tB-Chemical\nand\tO\nrisperidone\tB-Chemical\n(\tO\nt\tO\n(\tO\n30\tO\n)\tO\n=\tO\n-\tO\n2\tO\n.\tO\n59\tO\n;\tO\nP\tO\n=\tO\n.\tO\n02\tO\n)\tO\nand\tO\nolanzapine\tB-Chemical\nand\tO\nrisperidone\tB-Chemical\n(\tO\nt\tO\n(\tO\n30\tO\n)\tO\n=\tO\n-\tO\n2\tO\n.\tO\n34\tO\n,\tO\nP\tO\n=\tO\n.\tO\n03\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nBoth\tO\nnonobese\tO\nclozapine\tB-Chemical\n-\tO\nand\tO\nolanzapine\tB-Chemical\n-\tO\ntreated\tO\ngroups\tO\ndisplayed\tO\nsignificant\tO\ninsulin\tB-Disease\nresistance\tI-Disease\nand\tO\nimpairment\tO\nof\tO\nglucose\tB-Chemical\neffectiveness\tO\ncompared\tO\nwith\tO\nrisperidone\tB-Chemical\n-\tO\ntreated\tO\nsubjects\tO\n.\tO\n\nPatients\tO\ntaking\tO\nclozapine\tB-Chemical\nand\tO\nolanzapine\tB-Chemical\nmust\tO\nbe\tO\nexamined\tO\nfor\tO\ninsulin\tB-Disease\nresistance\tI-Disease\nand\tO\nits\tO\nconsequences\tO\n.\tO\n\nThoracic\tB-Disease\nhematomyelia\tI-Disease\nsecondary\tO\nto\tO\ncoumadin\tB-Chemical\nanticoagulant\tO\ntherapy\tO\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nthoracic\tB-Disease\nhematomyelia\tI-Disease\nsecondary\tO\nto\tO\nanticoagulant\tO\ntherapy\tO\nis\tO\npresented\tO\n.\tO\n\nClinical\tO\nfeatures\tO\n,\tO\nsimilar\tO\nto\tO\n2\tO\nother\tO\npreviously\tO\nreported\tO\ncases\tO\n,\tO\nare\tO\ndiscussed\tO\n.\tO\n\nA\tO\nhigh\tO\nindex\tO\nof\tO\nsuspicion\tO\nmay\tO\nlead\tO\nto\tO\na\tO\nquick\tO\ndiagnostic\tO\nprocedure\tO\nand\tO\nsuccessful\tO\ndecompressive\tO\nsurgery\tO\n.\tO\n\nMania\tB-Disease\nassociated\tO\nwith\tO\nfluoxetine\tB-Chemical\ntreatment\tO\nin\tO\nadolescents\tO\n.\tO\n\nFluoxetine\tB-Chemical\n,\tO\na\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitor\tO\n,\tO\nis\tO\ngaining\tO\nincreased\tO\nacceptance\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nadolescent\tO\ndepression\tB-Disease\n.\tO\n\nGenerally\tO\nsafe\tO\nand\tO\nwell\tO\ntolerated\tO\nby\tO\nadults\tO\n,\tO\nfluoxetine\tB-Chemical\nhas\tO\nbeen\tO\nreported\tO\nto\tO\ninduce\tO\nmania\tB-Disease\n.\tO\n\nThe\tO\ncases\tO\nof\tO\nfive\tO\ndepressed\tB-Disease\nadolescents\tO\n,\tO\n14\tO\n-\tO\n16\tO\nyears\tO\nof\tO\nage\tO\n,\tO\nwho\tO\ndeveloped\tO\nmania\tB-Disease\nduring\tO\npharmacotherapy\tO\nwith\tO\nfluoxetine\tB-Chemical\n,\tO\nare\tO\nreported\tO\nhere\tO\n.\tO\n\nApparent\tO\nrisk\tO\nfactors\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nmania\tB-Disease\nor\tO\nhypomania\tB-Disease\nduring\tO\nfluoxetine\tB-Chemical\npharmacotherapy\tO\nin\tO\nthis\tO\npopulation\tO\nwere\tO\nthe\tO\ncombination\tO\nof\tO\nattention\tB-Disease\n-\tI-Disease\ndeficit\tI-Disease\nhyperactivity\tI-Disease\ndisorder\tI-Disease\nand\tO\naffective\tO\ninstability\tO\n;\tO\nmajor\tO\ndepression\tB-Disease\nwith\tO\npsychotic\tB-Disease\nfeatures\tO\n;\tO\na\tO\nfamily\tO\nhistory\tO\nof\tO\naffective\tB-Disease\ndisorder\tI-Disease\n,\tO\nespecially\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\n;\tO\nand\tO\na\tO\ndiagnosis\tO\nof\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nFurther\tO\nstudy\tO\nis\tO\nneeded\tO\nto\tO\ndetermine\tO\nthe\tO\noptimal\tO\ndosage\tO\nand\tO\nto\tO\nidentify\tO\nrisk\tO\nfactors\tO\nthat\tO\nincrease\tO\nindividual\tO\nvulnerability\tO\nto\tO\nfluoxetine\tB-Chemical\ninduced\tO\nmania\tB-Disease\nin\tO\nadolescents\tO\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\nafter\tO\nhigh\tO\n-\tO\ndose\tO\nmelphalan\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nprimary\tB-Disease\nsystemic\tI-Disease\namyloidosis\tI-Disease\nduring\tO\nstem\tO\ncell\tO\ntransplantation\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nPatients\tO\nwith\tO\nprimary\tB-Disease\nsystemic\tI-Disease\namyloidosis\tI-Disease\n(\tO\nAL\tB-Disease\n)\tO\nhave\tO\na\tO\npoor\tO\nprognosis\tO\n.\tO\n\nMedian\tO\nsurvival\tO\ntime\tO\nfrom\tO\nstandard\tO\ntreatments\tO\nis\tO\nonly\tO\n17\tO\nmonths\tO\n.\tO\n\nHigh\tO\n-\tO\ndose\tO\nintravenous\tO\nmelphalan\tB-Chemical\nfollowed\tO\nby\tO\nperipheral\tO\nblood\tO\nstem\tO\ncell\tO\ntransplant\tO\n(\tO\nPBSCT\tO\n)\tO\nappears\tO\nto\tO\nbe\tO\nthe\tO\nmost\tO\npromising\tO\ntherapy\tO\n,\tO\nbut\tO\ntreatment\tO\nmortality\tO\ncan\tO\nbe\tO\nhigh\tO\n.\tO\n\nThe\tO\nauthors\tO\nhave\tO\nnoted\tO\nthe\tO\ndevelopment\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\nimmediately\tO\nafter\tO\nmelphalan\tB-Chemical\nconditioning\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\nfurther\tO\nexamine\tO\nits\tO\nrisk\tO\nfactors\tO\nand\tO\nimpact\tO\non\tO\nposttransplant\tO\nmortality\tO\n.\tO\n\nMETHODS\tO\n:\tO\nConsecutive\tO\nAL\tB-Disease\npatients\tO\nwho\tO\nunderwent\tO\nPBSCT\tO\nwere\tO\nstudied\tO\nretrospectively\tO\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\n(\tO\nARI\tB-Disease\n)\tO\nafter\tO\nhigh\tO\n-\tO\ndose\tO\nmelphalan\tB-Chemical\nwas\tO\ndefined\tO\nby\tO\na\tO\nminimum\tO\nincrease\tO\nof\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndL\tO\n(\tO\n44\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nin\tO\nthe\tO\nserum\tO\ncreatinine\tB-Chemical\nlevel\tO\nthat\tO\nis\tO\ngreater\tO\nthan\tO\n50\tO\n%\tO\nof\tO\nbaseline\tO\nimmediately\tO\nafter\tO\nconditioning\tO\n.\tO\n\nUrine\tO\nsediment\tO\nscore\tO\nwas\tO\nthe\tO\nsum\tO\nof\tO\nthe\tO\nindividual\tO\ntypes\tO\nof\tO\nsediment\tO\nidentified\tO\non\tO\nurine\tO\nmicroscopy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOf\tO\nthe\tO\n80\tO\npatients\tO\nstudied\tO\n,\tO\nARI\tB-Disease\ndeveloped\tO\nin\tO\n18\tO\n.\tO\n8\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\nafter\tO\nhigh\tO\n-\tO\ndose\tO\nmelphalan\tB-Chemical\n.\tO\n\nUnivariate\tO\nanalysis\tO\nidentified\tO\nage\tO\n,\tO\nhypoalbuminemia\tB-Disease\n,\tO\nheavy\tO\nproteinuria\tB-Disease\n,\tO\ndiuretic\tO\nuse\tO\n,\tO\nand\tO\nurine\tO\nsediment\tO\nscore\tO\n(\tO\n>\tO\n3\tO\n)\tO\nas\tO\nrisk\tO\nfactors\tO\n.\tO\n\nAge\tO\nand\tO\nurine\tO\nsediment\tO\nscore\tO\nremained\tO\nindependently\tO\nsignificant\tO\nrisk\tO\nfactors\tO\nin\tO\nthe\tO\nmultivariate\tO\nanalysis\tO\n.\tO\n\nPatients\tO\nwho\tO\nhad\tO\nARI\tB-Disease\nafter\tO\nhigh\tO\n-\tO\ndose\tO\nmelphalan\tB-Chemical\nunderwent\tO\ndialysis\tO\nmore\tO\noften\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n007\tO\n)\tO\n,\tO\nand\tO\nhad\tO\na\tO\nworse\tO\n1\tO\n-\tO\nyear\tO\nsurvival\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n03\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\ntiming\tO\nof\tO\nrenal\tB-Disease\ninjury\tI-Disease\nstrongly\tO\nsuggests\tO\nmelphalan\tB-Chemical\nas\tO\nthe\tO\ncausative\tO\nagent\tO\n.\tO\n\nOngoing\tO\ntubular\tB-Disease\ninjury\tI-Disease\nmay\tO\nbe\tO\na\tO\nprerequisite\tO\nfor\tO\nrenal\tB-Disease\ninjury\tI-Disease\nby\tO\nmelphalan\tB-Chemical\nas\tO\nevidenced\tO\nby\tO\nthe\tO\nactive\tO\nurinary\tO\nsediment\tO\n.\tO\n\nDevelopment\tO\nof\tO\nARI\tB-Disease\nadversely\tO\naffected\tO\nthe\tO\noutcome\tO\nafter\tO\nPBSCT\tO\n.\tO\n\nEffective\tO\npreventive\tO\nmeasures\tO\nmay\tO\nhelp\tO\ndecrease\tO\nthe\tO\ntreatment\tO\nmortality\tO\nof\tO\nPBSCT\tO\nin\tO\nAL\tB-Disease\npatients\tO\n.\tO\n\nFocal\tO\ncerebral\tB-Disease\nischemia\tI-Disease\nin\tO\nrats\tO\n:\tO\neffect\tO\nof\tO\nphenylephrine\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nduring\tO\nreperfusion\tO\n.\tO\n\nAfter\tO\n180\tO\nmin\tO\nof\tO\ntemporary\tO\nmiddle\tB-Disease\ncerebral\tI-Disease\nartery\tI-Disease\nocclusion\tI-Disease\nin\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n,\tO\nthe\tO\neffect\tO\nof\tO\nphenylephrine\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\non\tO\nischemic\tB-Disease\nbrain\tI-Disease\ninjury\tI-Disease\nand\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\npermeability\tO\nwas\tO\ndetermined\tO\n.\tO\n\nBlood\tO\npressure\tO\nwas\tO\nmanipulated\tO\nby\tO\none\tO\nof\tO\nthe\tO\nfollowing\tO\nschedules\tO\nduring\tO\n120\tO\nmin\tO\nof\tO\nreperfusion\tO\n:\tO\nControl\tO\n,\tO\nnormotensive\tO\nreperfusion\tO\n;\tO\n90\tO\n/\tO\nhypertension\tB-Disease\n(\tO\n90\tO\n/\tO\nHTN\tB-Disease\n)\tO\n,\tO\nblood\tO\npressure\tO\nwas\tO\nincreased\tO\nby\tO\n35\tO\nmm\tO\nHg\tO\nduring\tO\nthe\tO\ninitial\tO\n90\tO\nmin\tO\nof\tO\nreperfusion\tO\nonly\tO\n;\tO\n15\tO\n/\tO\nhypertension\tB-Disease\n(\tO\n15\tO\n/\tO\nHTN\tB-Disease\n)\tO\n,\tO\nnormotensive\tO\nreperfusion\tO\nfor\tO\n30\tO\nmin\tO\nfollowed\tO\nby\tO\n15\tO\nmin\tO\nof\tO\nhypertension\tB-Disease\nand\tO\n75\tO\nmin\tO\nof\tO\nnormotension\tO\n.\tO\n\nPart\tO\nA\tO\n,\tO\nfor\tO\neight\tO\nrats\tO\nin\tO\neach\tO\ngroup\tO\nbrain\tB-Disease\ninjury\tI-Disease\nwas\tO\nevaluated\tO\nby\tO\nstaining\tO\ntissue\tO\nusing\tO\n2\tB-Chemical\n,\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\ntriphenyltetrazolium\tI-Chemical\nchloride\tI-Chemical\nand\tO\nedema\tB-Disease\nwas\tO\nevaluated\tO\nby\tO\nmicrogravimetry\tO\n.\tO\n\nPart\tO\nB\tO\n,\tO\nfor\tO\neight\tO\ndifferent\tO\nrats\tO\nin\tO\neach\tO\ngroup\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\npermeability\tO\nwas\tO\nevaluated\tO\nby\tO\nmeasuring\tO\nthe\tO\namount\tO\nand\tO\nextent\tO\nof\tO\nextravasation\tO\nof\tO\nEvans\tO\nBlue\tO\ndye\tO\n.\tO\n\nBrain\tB-Disease\ninjury\tI-Disease\n(\tO\npercentage\tO\nof\tO\nthe\tO\nischemic\tB-Disease\nhemisphere\tI-Disease\n)\tO\nwas\tO\nless\tO\nin\tO\nthe\tO\n15\tO\n/\tO\nHTN\tB-Disease\ngroup\tO\n(\tO\n16\tO\n+\tO\n/\tO\n-\tO\n6\tO\n,\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nversus\tO\nthe\tO\n90\tO\n/\tO\nHTN\tB-Disease\ngroup\tO\n(\tO\n30\tO\n+\tO\n/\tO\n-\tO\n6\tO\n)\tO\n,\tO\nwhich\tO\nwas\tO\nin\tO\nturn\tO\nless\tO\nthan\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\n42\tO\n+\tO\n/\tO\n-\tO\n5\tO\n)\tO\n.\tO\n\nSpecific\tO\ngravity\tO\nwas\tO\ngreater\tO\nin\tO\nthe\tO\n15\tO\n/\tO\nHTN\tB-Disease\ngroup\tO\n(\tO\n1\tO\n.\tO\n043\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n002\tO\n)\tO\nversus\tO\nthe\tO\n90\tO\n/\tO\nHTN\tB-Disease\n(\tO\n1\tO\n.\tO\n036\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n003\tO\n)\tO\nand\tO\ncontrol\tO\n(\tO\n1\tO\n.\tO\n037\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n003\tO\n)\tO\ngroups\tO\n.\tO\n\nEvans\tB-Chemical\nBlue\tI-Chemical\n(\tO\nmug\tO\ng\tO\n-\tO\n1\tO\nof\tO\nbrain\tO\ntissue\tO\n)\tO\nwas\tO\ngreater\tO\nin\tO\nthe\tO\n90\tO\n/\tO\nHTN\tB-Disease\ngroup\tO\n(\tO\n24\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n0\tO\n)\tO\nversus\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\n12\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n1\tO\n)\tO\n,\tO\nwhich\tO\nwas\tO\nin\tO\nturn\tO\ngreater\tO\nthan\tO\nthe\tO\n15\tO\n/\tO\nHTN\tB-Disease\ngroup\tO\n(\tO\n7\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n2\tO\n)\tO\n.\tO\n\nThis\tO\nstudy\tO\nsupports\tO\na\tO\nhypothesis\tO\nthat\tO\nduring\tO\nreperfusion\tO\n,\tO\na\tO\nshort\tO\ninterval\tO\nof\tO\nhypertension\tB-Disease\ndecreases\tO\nbrain\tB-Disease\ninjury\tI-Disease\nand\tO\nedema\tB-Disease\n;\tO\nand\tO\nthat\tO\nsustained\tO\nhypertension\tB-Disease\nincreases\tO\nthe\tO\nrisk\tO\nof\tO\nvasogenic\tB-Disease\nedema\tI-Disease\n.\tO\n\nPeople\tO\naged\tO\nover\tO\n75\tO\nin\tO\natrial\tB-Disease\nfibrillation\tI-Disease\non\tO\nwarfarin\tB-Chemical\n:\tO\nthe\tO\nrate\tO\nof\tO\nmajor\tO\nhemorrhage\tB-Disease\nand\tO\nstroke\tB-Disease\nin\tO\nmore\tO\nthan\tO\n500\tO\npatient\tO\n-\tO\nyears\tO\nof\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nincidence\tO\nof\tO\nmajor\tO\nhemorrhage\tB-Disease\nand\tO\nstroke\tB-Disease\nin\tO\npeople\tO\naged\tO\n76\tO\nand\tO\nolder\tO\nwith\tO\natrial\tB-Disease\nfibrillation\tI-Disease\non\tO\nadjusted\tO\n-\tO\ndose\tO\nwarfarin\tB-Chemical\nwho\tO\nhad\tO\nbeen\tO\nrecently\tO\nbeen\tO\nadmitted\tO\nto\tO\nhospital\tO\n.\tO\n\nDESIGN\tO\n:\tO\nA\tO\nretrospective\tO\nobservational\tO\ncohort\tO\nstudy\tO\n.\tO\n\nSETTING\tO\n:\tO\nA\tO\nmajor\tO\nhealthcare\tO\nnetwork\tO\ninvolving\tO\nfour\tO\ntertiary\tO\nhospitals\tO\n.\tO\n\nPARTICIPANTS\tO\n:\tO\nTwo\tO\nhundred\tO\nthirty\tO\n-\tO\nfive\tO\npatients\tO\naged\tO\n76\tO\nand\tO\nolder\tO\nadmitted\tO\nto\tO\na\tO\nmajor\tO\nhealthcare\tO\nnetwork\tO\nbetween\tO\nJuly\tO\n1\tO\n,\tO\n2001\tO\n,\tO\nand\tO\nJune\tO\n30\tO\n,\tO\n2002\tO\n,\tO\nwith\tO\natrial\tB-Disease\nfibrillation\tI-Disease\non\tO\nwarfarin\tB-Chemical\nwere\tO\nenrolled\tO\n.\tO\n\nMEASUREMENTS\tO\n:\tO\nInformation\tO\nregarding\tO\nmajor\tO\nbleeding\tB-Disease\nepisodes\tO\n,\tO\nstrokes\tB-Disease\n,\tO\nand\tO\nwarfarin\tB-Chemical\nuse\tO\nwas\tO\nobtained\tO\nfrom\tO\npatients\tO\n,\tO\nrelatives\tO\n,\tO\nprimary\tO\nphysicians\tO\n,\tO\nand\tO\nmedical\tO\nrecords\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTwo\tO\nhundred\tO\ntwenty\tO\n-\tO\neight\tO\npatients\tO\n(\tO\n42\tO\n%\tO\nmen\tO\n)\tO\nwith\tO\na\tO\nmean\tO\nage\tO\nof\tO\n81\tO\n.\tO\n1\tO\n(\tO\nrange\tO\n76\tO\n-\tO\n94\tO\n)\tO\nwere\tO\nincluded\tO\nin\tO\nthe\tO\nanalysis\tO\n.\tO\n\nTotal\tO\nfollow\tO\n-\tO\nup\tO\non\tO\nwarfarin\tB-Chemical\nwas\tO\n530\tO\nyears\tO\n(\tO\nmean\tO\n28\tO\nmonths\tO\n)\tO\n.\tO\n\nThere\tO\nwere\tO\n53\tO\nmajor\tO\nhemorrhages\tB-Disease\n,\tO\nfor\tO\nan\tO\nannual\tO\nrate\tO\nof\tO\n10\tO\n.\tO\n0\tO\n%\tO\n,\tO\nincluding\tO\n24\tO\n(\tO\n45\tO\n.\tO\n3\tO\n%\tO\n)\tO\nlife\tO\n-\tO\nthreatening\tO\nand\tO\nfive\tO\n(\tO\n9\tO\n.\tO\n4\tO\n%\tO\n)\tO\nfatal\tO\nbleeds\tO\n.\tO\n\nThe\tO\nannual\tO\nstroke\tB-Disease\nrate\tO\nafter\tO\ninitiation\tO\nof\tO\nwarfarin\tB-Chemical\nwas\tO\n2\tO\n.\tO\n6\tO\n%\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nrate\tO\nof\tO\nmajor\tO\nhemorrhage\tB-Disease\nwas\tO\nhigh\tO\nin\tO\nthis\tO\nold\tO\n,\tO\nfrail\tO\ngroup\tO\n,\tO\nbut\tO\nexcluding\tO\nfatalities\tO\n,\tO\nresulted\tO\nin\tO\nno\tO\nlong\tO\n-\tO\nterm\tO\nsequelae\tO\n,\tO\nand\tO\nthe\tO\nstroke\tB-Disease\nrate\tO\non\tO\nwarfarin\tB-Chemical\nwas\tO\nlow\tO\n,\tO\ndemonstrating\tO\nhow\tO\neffective\tO\nwarfarin\tB-Chemical\ntreatment\tO\nis\tO\n.\tO\n\nSafety\tO\nof\tO\ncelecoxib\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nadverse\tO\nskin\tB-Disease\nreactions\tI-Disease\nto\tO\nacetaminophen\tB-Chemical\n(\tO\nparacetamol\tB-Chemical\n)\tO\nand\tO\nnimesulide\tB-Chemical\nassociated\tO\nor\tO\nnot\tO\nwith\tO\ncommon\tO\nnon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAcetaminophen\tB-Chemical\n(\tO\nparacetamol\tB-Chemical\n-\tO\n-\tO\nP\tB-Chemical\n)\tO\nand\tO\nNimesulide\tB-Chemical\n(\tO\nN\tB-Chemical\n)\tO\nare\tO\nwidely\tO\nused\tO\nanalgesic\tO\n-\tO\nantipyretic\tO\n/\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\n.\tO\n\nThe\tO\nrate\tO\nof\tO\nadverse\tO\nhypersensitivity\tB-Disease\nreactions\tO\nto\tO\nthese\tO\nagents\tO\nis\tO\ngenerally\tO\nlow\tO\n.\tO\n\nOn\tO\nthe\tO\ncontrary\tO\nnon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\n(\tO\nNSAIDs\tO\n)\tO\nare\tO\ncommonly\tO\ninvolved\tO\nin\tO\nsuch\tO\nreactions\tO\n.\tO\n\nCelecoxib\tB-Chemical\n(\tO\nCE\tB-Chemical\n)\tO\nis\tO\na\tO\nnovel\tO\ndrug\tO\n,\tO\nwith\tO\nhigh\tO\nselectivity\tO\nand\tO\naffinity\tO\nfor\tO\nCOX\tO\n-\tO\n2\tO\nenzyme\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nWe\tO\nevaluated\tO\nthe\tO\ntolerability\tO\nof\tO\nCE\tB-Chemical\nin\tO\na\tO\ngroup\tO\nof\tO\npatients\tO\nwith\tO\ndocumented\tO\nhistory\tO\nof\tO\nadverse\tO\ncutaneous\tB-Disease\nreactions\tI-Disease\nto\tO\nP\tB-Chemical\nand\tO\nN\tB-Chemical\nassociated\tO\nor\tO\nnot\tO\nto\tO\nclassic\tO\nNSAIDs\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nstudied\tO\n9\tO\npatients\tO\nwith\tO\nhypersensitivity\tB-Disease\nto\tO\nP\tB-Chemical\nand\tO\nN\tB-Chemical\nwith\tO\nor\tO\nwithout\tO\nassociated\tO\nreactions\tO\nto\tO\nclassic\tO\nNSAIDs\tO\n.\tO\n\nThe\tO\ndiagnosis\tO\nof\tO\nP\tB-Chemical\nand\tO\nN\tB-Chemical\n-\tO\ninduced\tO\nskin\tB-Disease\nreactions\tI-Disease\nwas\tO\nbased\tO\nin\tO\nvivo\tO\nchallenge\tO\n.\tO\n\nThe\tO\nplacebo\tO\nwas\tO\nblindly\tO\nadministered\tO\nat\tO\nthe\tO\nbeginning\tO\nof\tO\neach\tO\nchallenge\tO\n.\tO\n\nAfter\tO\nthree\tO\ndays\tO\n,\tO\na\tO\ncumulative\tO\ndosage\tO\nof\tO\n200\tO\nmg\tO\nof\tO\nCE\tB-Chemical\nin\tO\nrefracted\tO\ndoses\tO\nwere\tO\ngiven\tO\n.\tO\n\nAfter\tO\n2\tO\n-\tO\n3\tO\ndays\tO\n,\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\n200\tO\nmg\tO\nwas\tO\nadministered\tO\n.\tO\n\nAll\tO\npatients\tO\nwere\tO\nobserved\tO\nfor\tO\n6\tO\nhours\tO\nafter\tO\neach\tO\nchallenge\tO\n,\tO\nand\tO\ncontrolled\tO\nagain\tO\nafter\tO\n24\tO\nhours\tO\nto\tO\nexclude\tO\ndelayed\tO\nreactions\tO\n.\tO\n\nThe\tO\nchallenge\tO\nwas\tO\nconsidered\tO\npositive\tO\nif\tO\none\tO\nor\tO\nmore\tO\nof\tO\nthe\tO\nfollowing\tO\nappeared\tO\n:\tO\nerythema\tB-Disease\n,\tO\nrush\tO\nor\tO\nurticaria\tB-Disease\n-\tO\nangioedema\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nNo\tO\nreaction\tO\nwas\tO\nobserved\tO\nwith\tO\nplacebo\tO\nand\tO\neight\tO\npatients\tO\n(\tO\n88\tO\n.\tO\n8\tO\n%\tO\n)\tO\ntolerated\tO\nCE\tB-Chemical\n.\tO\n\nOnly\tO\none\tO\npatient\tO\ndeveloped\tO\na\tO\nmoderate\tO\nangioedema\tB-Disease\nof\tO\nthe\tO\nlips\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOnly\tO\none\tO\nhypersensitivity\tB-Disease\nreaction\tO\nto\tO\nCE\tB-Chemical\nwas\tO\ndocumented\tO\namong\tO\n9\tO\nP\tB-Chemical\nand\tO\nN\tB-Chemical\n-\tO\nhighly\tO\nNSAIDs\tO\nintolerant\tO\npatients\tO\n.\tO\n\nThus\tO\n,\tO\nwe\tO\nconclude\tO\nthat\tO\nCE\tB-Chemical\nis\tO\na\tO\nreasonably\tO\nsafe\tO\nalternative\tO\nto\tO\nbe\tO\nused\tO\nin\tO\nsubjects\tO\nwho\tO\ndo\tO\nnot\tO\ntolerate\tO\nP\tB-Chemical\nand\tO\nN\tB-Chemical\n.\tO\n\nCase\tO\n-\tO\ncontrol\tO\nstudy\tO\nof\tO\nregular\tO\nanalgesic\tO\nand\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\nuse\tO\nand\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nStudies\tO\non\tO\nthe\tO\nassociation\tO\nbetween\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\naspirin\tB-Chemical\nand\tO\nother\tO\nanalgesic\tO\nand\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\n(\tO\nNSAIDs\tO\n)\tO\nand\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n(\tO\nESRD\tB-Disease\n)\tO\nhave\tO\ngiven\tO\nconflicting\tO\nresults\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\nexamine\tO\nthis\tO\nassociation\tO\n,\tO\na\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nwith\tO\nincident\tO\ncases\tO\nof\tO\nESRD\tB-Disease\nwas\tO\ncarried\tO\nout\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\ncases\tO\nwere\tO\nall\tO\npatients\tO\nentering\tO\nthe\tO\nlocal\tO\ndialysis\tO\nprogram\tO\nbecause\tO\nof\tO\nESRD\tB-Disease\nin\tO\nthe\tO\nstudy\tO\narea\tO\nbetween\tO\nJune\tO\n1\tO\n,\tO\n1995\tO\nand\tO\nNovember\tO\n30\tO\n,\tO\n1997\tO\n.\tO\n\nThey\tO\nwere\tO\nclassified\tO\naccording\tO\nto\tO\nthe\tO\nunderlying\tO\ndisease\tO\n,\tO\nwhich\tO\nhad\tO\npresumably\tO\nled\tO\nthem\tO\nto\tO\nESRD\tB-Disease\n.\tO\n\nControls\tO\nwere\tO\npatients\tO\nadmitted\tO\nto\tO\nthe\tO\nsame\tO\nhospitals\tO\nfrom\tO\nwhere\tO\nthe\tO\ncases\tO\narose\tO\n,\tO\nalso\tO\nmatched\tO\nby\tO\nage\tO\nand\tO\nsex\tO\n.\tO\n\nOdds\tO\nratios\tO\nwere\tO\ncalculated\tO\nusing\tO\na\tO\nconditional\tO\nlogistic\tO\nmodel\tO\n,\tO\nincluding\tO\npotential\tO\nconfounding\tO\nfactors\tO\n,\tO\nboth\tO\nfor\tO\nthe\tO\nwhole\tO\nstudy\tO\npopulation\tO\nand\tO\nfor\tO\nthe\tO\nvarious\tO\nunderlying\tO\ndiseases\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFive\tO\nhundred\tO\nand\tO\neighty\tO\n-\tO\nthree\tO\ncases\tO\nand\tO\n1190\tO\ncontrols\tO\nwere\tO\nincluded\tO\nin\tO\nthe\tO\nanalysis\tO\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nany\tO\nanalgesic\tO\nwas\tO\nassociated\tO\nwith\tO\nan\tO\noverall\tO\nodds\tO\nratio\tO\nof\tO\n1\tO\n.\tO\n22\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n0\tO\n.\tO\n89\tO\n-\tO\n1\tO\n.\tO\n66\tO\n)\tO\n.\tO\n\nFor\tO\nspecific\tO\ngroups\tO\nof\tO\ndrugs\tO\n,\tO\nthe\tO\nrisks\tO\nwere\tO\n1\tO\n.\tO\n56\tO\n(\tO\n1\tO\n.\tO\n05\tO\n-\tO\n2\tO\n.\tO\n30\tO\n)\tO\nfor\tO\naspirin\tB-Chemical\n,\tO\n1\tO\n.\tO\n03\tO\n(\tO\n0\tO\n.\tO\n60\tO\n-\tO\n1\tO\n.\tO\n76\tO\n)\tO\nfor\tO\npyrazolones\tB-Chemical\n,\tO\n0\tO\n.\tO\n80\tO\n(\tO\n0\tO\n.\tO\n39\tO\n-\tO\n1\tO\n.\tO\n63\tO\n)\tO\nfor\tO\nparacetamol\tB-Chemical\n,\tO\nand\tO\n0\tO\n.\tO\n94\tO\n(\tO\n0\tO\n.\tO\n57\tO\n-\tO\n1\tO\n.\tO\n56\tO\n)\tO\nfor\tO\nnonaspirin\tO\nNSAIDs\tO\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nESRD\tB-Disease\nassociated\tO\nwith\tO\naspirin\tB-Chemical\nwas\tO\nrelated\tO\nto\tO\nthe\tO\ncumulated\tO\ndose\tO\nand\tO\nduration\tO\nof\tO\nuse\tO\n,\tO\nand\tO\nit\tO\nwas\tO\nparticularly\tO\nhigh\tO\namong\tO\nthe\tO\nsubset\tO\nof\tO\npatients\tO\nwith\tO\nvascular\tO\nnephropathy\tB-Disease\nas\tO\nunderlying\tO\ndisease\tO\n[\tO\n2\tO\n.\tO\n35\tO\n(\tO\n1\tO\n.\tO\n17\tO\n-\tO\n4\tO\n.\tO\n72\tO\n)\tO\n]\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\ndata\tO\nindicate\tO\nthat\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nnonaspirin\tO\nanalgesic\tO\ndrugs\tO\nand\tO\nNSAIDs\tO\nis\tO\nnot\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nESRD\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nchronic\tO\nuse\tO\nof\tO\naspirin\tB-Chemical\nmay\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nESRD\tB-Disease\n.\tO\n\nTwo\tO\ncases\tO\nof\tO\namisulpride\tB-Chemical\noverdose\tB-Disease\n:\tO\na\tO\ncause\tO\nfor\tO\nprolonged\tB-Disease\nQT\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nTwo\tO\ncases\tO\nof\tO\ndeliberate\tO\nself\tO\n-\tO\npoisoning\tB-Disease\nwith\tO\n5\tO\ng\tO\nand\tO\n3\tO\n.\tO\n6\tO\ng\tO\nof\tO\namisulpride\tB-Chemical\n,\tO\nrespectively\tO\n,\tO\nare\tO\nreported\tO\n.\tO\n\nIn\tO\nboth\tO\ncases\tO\n,\tO\nQT\tB-Disease\nprolongation\tI-Disease\nand\tO\nhypocalcaemia\tB-Disease\nwere\tO\nnoted\tO\n.\tO\n\nThe\tO\nQT\tB-Disease\nprolongation\tI-Disease\nappeared\tO\nto\tO\nrespond\tO\nto\tO\nadministration\tO\nof\tO\ni\tO\n.\tO\nv\tO\n.\tO\ncalcium\tB-Chemical\ngluconate\tI-Chemical\n.\tO\n\nGrowth\tO\n-\tO\nassociated\tO\nprotein\tO\n43\tO\nexpression\tO\nin\tO\nhippocampal\tO\nmolecular\tO\nlayer\tO\nof\tO\nchronic\tO\nepileptic\tB-Disease\nrats\tO\ntreated\tO\nwith\tO\ncycloheximide\tB-Chemical\n.\tO\n\nPURPOSE\tO\n:\tO\nGAP43\tO\nhas\tO\nbeen\tO\nthought\tO\nto\tO\nbe\tO\nlinked\tO\nwith\tO\nmossy\tO\nfiber\tO\nsprouting\tO\n(\tO\nMFS\tO\n)\tO\nin\tO\nvarious\tO\nexperimental\tO\nmodels\tO\nof\tO\nepilepsy\tB-Disease\n.\tO\n\nTo\tO\ninvestigate\tO\nhow\tO\nGAP43\tO\nexpression\tO\n(\tO\nGAP43\tO\n-\tO\nir\tO\n)\tO\ncorrelates\tO\nwith\tO\nMFS\tO\n,\tO\nwe\tO\nassessed\tO\nthe\tO\nintensity\tO\n(\tO\ndensitometry\tO\n)\tO\nand\tO\nextension\tO\n(\tO\nwidth\tO\n)\tO\nof\tO\nGAP43\tO\n-\tO\nir\tO\nin\tO\nthe\tO\ninner\tO\nmolecular\tO\nlayer\tO\nof\tO\nthe\tO\ndentate\tO\ngyrus\tO\n(\tO\nIML\tO\n)\tO\nof\tO\nrats\tO\nsubject\tO\nto\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\ninduced\tO\nby\tO\npilocarpine\tB-Chemical\n(\tO\nPilo\tB-Chemical\n)\tO\n,\tO\npreviously\tO\ninjected\tO\nor\tO\nnot\tO\nwith\tO\ncycloheximide\tB-Chemical\n(\tO\nCHX\tB-Chemical\n)\tO\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\ninhibit\tO\nMFS\tO\n.\tO\n\nMETHODS\tO\n:\tO\nCHX\tB-Chemical\nwas\tO\ninjected\tO\nbefore\tO\nthe\tO\nPilo\tB-Chemical\ninjection\tO\nin\tO\nadult\tO\nWistar\tO\nrats\tO\n.\tO\n\nThe\tO\nPilo\tB-Chemical\ngroup\tO\nwas\tO\ninjected\tO\nwith\tO\nthe\tO\nsame\tO\ndrugs\tO\n,\tO\nexcept\tO\nfor\tO\nCHX\tB-Chemical\n.\tO\n\nAnimals\tO\nwere\tO\nkilled\tO\nbetween\tO\n30\tO\nand\tO\n60\tO\ndays\tO\nlater\tO\n,\tO\nand\tO\nbrain\tO\nsections\tO\nwere\tO\nprocessed\tO\nfor\tO\nGAP43\tO\nimmunohistochemistry\tO\n.\tO\n\nRESULTS\tO\n:\tO\nDensitometry\tO\nshowed\tO\nno\tO\nsignificant\tO\ndifference\tO\nregarding\tO\nGAP43\tO\n-\tO\nir\tO\nin\tO\nthe\tO\nIML\tO\nbetween\tO\nPilo\tB-Chemical\n,\tO\nCHX\tB-Chemical\n+\tO\nPilo\tB-Chemical\n,\tO\nand\tO\ncontrol\tO\ngroups\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nresults\tO\nof\tO\nthe\tO\nwidth\tO\nof\tO\nthe\tO\nGAP43\tO\n-\tO\nir\tO\nband\tO\nin\tO\nthe\tO\nIML\tO\nshowed\tO\nthat\tO\nCHX\tB-Chemical\n+\tO\nPilo\tB-Chemical\nand\tO\ncontrol\tO\nanimals\tO\nhad\tO\na\tO\nsignificantly\tO\nlarger\tO\nband\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n03\tO\n)\tO\nas\tO\ncompared\tO\nwith\tO\nthat\tO\nin\tO\nthe\tO\nPilo\tB-Chemical\ngroup\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nOur\tO\ncurrent\tO\nfinding\tO\nthat\tO\nanimals\tO\nin\tO\nthe\tO\nCHX\tB-Chemical\n+\tO\nPilo\tB-Chemical\ngroup\tO\nhave\tO\na\tO\nGAP43\tO\n-\tO\nir\tO\nband\tO\nin\tO\nthe\tO\nIML\tO\n,\tO\nsimilar\tO\nto\tO\nthat\tO\nof\tO\ncontrols\tO\n,\tO\nreinforces\tO\nprior\tO\ndata\tO\non\tO\nthe\tO\nblockade\tO\nof\tO\nMFS\tO\nin\tO\nthese\tO\nanimals\tO\n.\tO\n\nThe\tO\nchange\tO\nin\tO\nGAP43\tO\n-\tO\nir\tO\npresent\tO\nin\tO\nPilo\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\nwas\tO\na\tO\nthinning\tO\nof\tO\nthe\tO\nband\tO\nto\tO\na\tO\nvery\tO\nnarrow\tO\nlayer\tO\njust\tO\nabove\tO\nthe\tO\ngranule\tO\ncell\tO\nlayer\tO\nthat\tO\nis\tO\nlikely\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nloss\tO\nof\tO\nhilar\tO\ncell\tO\nprojections\tO\nthat\tO\nexpress\tO\nGAP\tO\n-\tO\n43\tO\n.\tO\n\nNicotine\tB-Chemical\nantagonizes\tO\ncaffeine\tB-Chemical\n-\tO\nbut\tO\nnot\tO\npentylenetetrazole\tB-Chemical\n-\tO\ninduced\tO\nanxiogenic\tO\neffect\tO\nin\tO\nmice\tO\n.\tO\n\nRATIONALE\tO\n:\tO\nNicotine\tB-Chemical\nand\tO\ncaffeine\tB-Chemical\nare\tO\nwidely\tO\nconsumed\tO\nlicit\tO\npsychoactive\tO\ndrugs\tO\nworldwide\tO\n.\tO\n\nEpidemiological\tO\nstudies\tO\nshowed\tO\nthat\tO\nthey\tO\nwere\tO\ngenerally\tO\nused\tO\nconcurrently\tO\n.\tO\n\nAlthough\tO\nsome\tO\nstudies\tO\nin\tO\nexperimental\tO\nanimals\tO\nindicate\tO\nclear\tO\npharmacological\tO\ninteractions\tO\nbetween\tO\nthem\tO\n,\tO\nno\tO\nstudies\tO\nhave\tO\nshown\tO\na\tO\nspecific\tO\ninteraction\tO\non\tO\nanxiety\tB-Disease\nresponses\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\npresent\tO\nstudy\tO\ninvestigates\tO\nthe\tO\neffects\tO\nof\tO\nnicotine\tB-Chemical\non\tO\nanxiety\tB-Disease\ninduced\tO\nby\tO\ncaffeine\tB-Chemical\nand\tO\nanother\tO\nanxiogenic\tO\ndrug\tO\n,\tO\npentylenetetrazole\tB-Chemical\n,\tO\nin\tO\nmice\tO\n.\tO\n\nThe\tO\nelevated\tO\nplus\tO\n-\tO\nmaze\tO\n(\tO\nEPM\tO\n)\tO\ntest\tO\nwas\tO\nused\tO\nto\tO\nevaluate\tO\nthe\tO\neffects\tO\nof\tO\ndrugs\tO\non\tO\nanxiety\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nAdult\tO\nmale\tO\nSwiss\tO\nWebster\tO\nmice\tO\n(\tO\n25\tO\n-\tO\n32\tO\ng\tO\n)\tO\nwere\tO\ngiven\tO\nnicotine\tB-Chemical\n(\tO\n0\tO\n.\tO\n05\tO\n-\tO\n0\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nor\tO\nsaline\tO\n10\tO\nmin\tO\nbefore\tO\ncaffeine\tB-Chemical\n(\tO\n70\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nor\tO\npentylenetetrazole\tB-Chemical\n(\tO\n15\tO\nand\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\ninjections\tO\n.\tO\n\nAfter\tO\n15\tO\nmin\tO\n,\tO\nmice\tO\nwere\tO\nevaluated\tO\nfor\tO\ntheir\tO\nopen\tO\n-\tO\nand\tO\nclosed\tO\n-\tO\narm\tO\ntime\tO\nand\tO\nentries\tO\non\tO\nthe\tO\nEPM\tO\nfor\tO\na\tO\n10\tO\n-\tO\nmin\tO\nsession\tO\n.\tO\n\nLocomotor\tO\nactivity\tO\nwas\tO\nrecorded\tO\nfor\tO\nindividual\tO\ngroups\tO\nby\tO\nusing\tO\nthe\tO\nsame\tO\ntreatment\tO\nprotocol\tO\nwith\tO\nthe\tO\nEPM\tO\ntest\tO\n.\tO\n\nRESULTS\tO\n:\tO\nNicotine\tB-Chemical\n(\tO\n0\tO\n.\tO\n05\tO\n-\tO\n0\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nitself\tO\ndid\tO\nnot\tO\nproduce\tO\nany\tO\nsignificant\tO\neffect\tO\nin\tO\nthe\tO\nEPM\tO\ntest\tO\n,\tO\nwhereas\tO\ncaffeine\tB-Chemical\n(\tO\n70\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\npentylenetetrazole\tB-Chemical\n(\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nproduced\tO\nan\tO\nanxiogenic\tO\neffect\tO\n,\tO\napparent\tO\nwith\tO\ndecreases\tO\nin\tO\nopen\tO\n-\tO\narm\tO\ntime\tO\nand\tO\nentry\tO\n.\tO\n\nNicotine\tB-Chemical\n(\tO\n0\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\npretreatment\tO\nblocked\tO\nthe\tO\ncaffeine\tB-Chemical\n-\tO\nbut\tO\nnot\tO\npentylenetetrazole\tB-Chemical\n-\tO\ninduced\tO\nanxiety\tB-Disease\n.\tO\n\nAdministration\tO\nof\tO\neach\tO\ndrug\tO\nand\tO\ntheir\tO\ncombinations\tO\ndid\tO\nnot\tO\nproduce\tO\nany\tO\neffect\tO\non\tO\nlocomotor\tO\nactivity\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nOur\tO\nresults\tO\nsuggest\tO\nthat\tO\nthe\tO\nantagonistic\tO\neffect\tO\nof\tO\nnicotine\tB-Chemical\non\tO\ncaffeine\tB-Chemical\n-\tO\ninduced\tO\nanxiety\tB-Disease\nis\tO\nspecific\tO\nto\tO\ncaffeine\tB-Chemical\n,\tO\ninstead\tO\nof\tO\na\tO\nnon\tO\n-\tO\nspecific\tO\nanxiolytic\tO\neffect\tO\n.\tO\n\nThus\tO\n,\tO\nit\tO\nmay\tO\nextend\tO\nthe\tO\ncurrent\tO\nfindings\tO\non\tO\nthe\tO\ninteraction\tO\nbetween\tO\nnicotine\tB-Chemical\nand\tO\ncaffeine\tB-Chemical\n.\tO\n\nLong\tO\nterm\tO\nhormone\tO\ntherapy\tO\nfor\tO\nperimenopausal\tO\nand\tO\npostmenopausal\tO\nwomen\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nHormone\tO\ntherapy\tO\n(\tO\nHT\tO\n)\tO\nis\tO\nwidely\tO\nused\tO\nfor\tO\ncontrolling\tO\nmenopausal\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nIt\tO\nhas\tO\nalso\tO\nbeen\tO\nused\tO\nfor\tO\nthe\tO\nmanagement\tO\nand\tO\nprevention\tO\nof\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n,\tO\nosteoporosis\tB-Disease\nand\tO\ndementia\tB-Disease\nin\tO\nolder\tO\nwomen\tO\nbut\tO\nthe\tO\nevidence\tO\nsupporting\tO\nits\tO\nuse\tO\nfor\tO\nthese\tO\nindications\tO\nis\tO\nlargely\tO\nobservational\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nassess\tO\nthe\tO\neffect\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nHT\tO\non\tO\nmortality\tO\n,\tO\nheart\tB-Disease\ndisease\tI-Disease\n,\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n,\tO\nstroke\tB-Disease\n,\tO\ntransient\tB-Disease\nischaemic\tI-Disease\nattacks\tI-Disease\n,\tO\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\ncolorectal\tB-Disease\ncancer\tI-Disease\n,\tO\novarian\tB-Disease\ncancer\tI-Disease\n,\tO\nendometrial\tB-Disease\ncancer\tI-Disease\n,\tO\ngallbladder\tB-Disease\ndisease\tI-Disease\n,\tO\ncognitive\tO\nfunction\tO\n,\tO\ndementia\tB-Disease\n,\tO\nfractures\tB-Disease\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nSEARCH\tO\nSTRATEGY\tO\n:\tO\nWe\tO\nsearched\tO\nthe\tO\nfollowing\tO\ndatabases\tO\nup\tO\nto\tO\nNovember\tO\n2004\tO\n:\tO\nthe\tO\nCochrane\tO\nMenstrual\tO\nDisorders\tO\nand\tO\nSubfertility\tO\nGroup\tO\nTrials\tO\nRegister\tO\n,\tO\nCochrane\tO\nCentral\tO\nRegister\tO\nof\tO\nControlled\tO\nTrials\tO\n(\tO\nCENTRAL\tO\n)\tO\n,\tO\nMEDLINE\tO\n,\tO\nEMBASE\tO\n,\tO\nBiological\tO\nAbstracts\tO\n.\tO\n\nRelevant\tO\nnon\tO\n-\tO\nindexed\tO\njournals\tO\nand\tO\nconference\tO\nabstracts\tO\nwere\tO\nalso\tO\nsearched\tO\n.\tO\n\nSELECTION\tO\nCRITERIA\tO\n:\tO\nRandomised\tO\ndouble\tO\n-\tO\nblind\tO\ntrials\tO\nof\tO\nHT\tO\n(\tO\noestrogens\tB-Chemical\nwith\tO\nor\tO\nwithout\tO\nprogestogens\tB-Chemical\n)\tO\nversus\tO\nplacebo\tO\n,\tO\ntaken\tO\nfor\tO\nat\tO\nleast\tO\none\tO\nyear\tO\nby\tO\nperimenopausal\tO\nor\tO\npostmenopausal\tO\nwomen\tO\n.\tO\n\nDATA\tO\nCOLLECTION\tO\nAND\tO\nANALYSIS\tO\n:\tO\nFifteen\tO\nRCTs\tO\nwere\tO\nincluded\tO\n.\tO\n\nTrials\tO\nwere\tO\nassessed\tO\nfor\tO\nquality\tO\nand\tO\ntwo\tO\nreview\tO\nauthors\tO\nextracted\tO\ndata\tO\nindependently\tO\n.\tO\n\nThey\tO\ncalculated\tO\nrisk\tO\nratios\tO\nfor\tO\ndichotomous\tO\noutcomes\tO\nand\tO\nweighted\tO\nmean\tO\ndifferences\tO\nfor\tO\ncontinuous\tO\noutcomes\tO\n.\tO\n\nClinical\tO\nheterogeneity\tO\nprecluded\tO\nmeta\tO\n-\tO\nanalysis\tO\nfor\tO\nmost\tO\noutcomes\tO\n.\tO\n\nMAIN\tO\nRESULTS\tO\n:\tO\nAll\tO\nthe\tO\nstatistically\tO\nsignificant\tO\nresults\tO\nwere\tO\nderived\tO\nfrom\tO\nthe\tO\ntwo\tO\nbiggest\tO\ntrials\tO\n.\tO\n\nIn\tO\nrelatively\tO\nhealthy\tO\nwomen\tO\n,\tO\ncombined\tO\ncontinuous\tO\nHT\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\nor\tO\ncoronary\tO\nevent\tO\n(\tO\nafter\tO\none\tO\nyear\tO\n'\tO\ns\tO\nuse\tO\n)\tO\n,\tO\nstroke\tB-Disease\n(\tO\nafter\tO\n3\tO\nyears\tO\n)\tO\n,\tO\nbreast\tB-Disease\ncancer\tI-Disease\n(\tO\nafter\tO\n5\tO\nyears\tO\n)\tO\nand\tO\ngallbladder\tB-Disease\ndisease\tI-Disease\n.\tO\n\nLong\tO\n-\tO\nterm\tO\noestrogen\tB-Chemical\n-\tO\nonly\tO\nHT\tO\nalso\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nrisk\tO\nof\tO\nstroke\tB-Disease\nand\tO\ngallbladder\tB-Disease\ndisease\tI-Disease\n.\tO\n\nOverall\tO\n,\tO\nthe\tO\nonly\tO\nstatistically\tO\nsignificant\tO\nbenefits\tO\nof\tO\nHT\tO\nwere\tO\na\tO\ndecreased\tO\nincidence\tO\nof\tO\nfractures\tB-Disease\nand\tO\ncolon\tB-Disease\ncancer\tI-Disease\nwith\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\n.\tO\n\nAmong\tO\nrelatively\tO\nhealthy\tO\nwomen\tO\nover\tO\n65\tO\nyears\tO\ntaking\tO\ncontinuous\tO\ncombined\tO\nHT\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nstatistically\tO\nsignificant\tO\nincrease\tO\nin\tO\nthe\tO\nincidence\tO\nof\tO\ndementia\tB-Disease\n.\tO\n\nAmong\tO\nwomen\tO\nwith\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n,\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\ncombined\tO\ncontinuous\tO\nHT\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n.\tO\n\nNo\tO\ntrials\tO\nfocussed\tO\nspecifically\tO\non\tO\nyounger\tO\nwomen\tO\n.\tO\n\nHowever\tO\n,\tO\none\tO\ntrial\tO\nanalysed\tO\nsubgroups\tO\nof\tO\n2839\tO\nrelatively\tO\nhealthy\tO\n50\tO\nto\tO\n59\tO\nyear\tO\n-\tO\nold\tO\nwomen\tO\ntaking\tO\ncombined\tO\ncontinuous\tO\nHT\tO\nand\tO\n1637\tO\ntaking\tO\noestrogen\tB-Chemical\n-\tO\nonly\tO\nHT\tO\n,\tO\nversus\tO\nsimilar\tO\n-\tO\nsized\tO\nplacebo\tO\ngroups\tO\n.\tO\n\nThe\tO\nonly\tO\nsignificantly\tO\nincreased\tO\nrisk\tO\nreported\tO\nwas\tO\nfor\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\nin\tO\nwomen\tO\ntaking\tO\ncombined\tO\ncontinuous\tO\nHT\tO\n;\tO\ntheir\tO\nabsolute\tO\nrisk\tO\nremained\tO\nvery\tO\nlow\tO\n.\tO\n\nAUTHORS\tO\n'\tO\nCONCLUSIONS\tO\n:\tO\nHT\tO\nis\tO\nnot\tO\nindicated\tO\nfor\tO\nthe\tO\nroutine\tO\nmanagement\tO\nof\tO\nchronic\tB-Disease\ndisease\tI-Disease\n.\tO\n\nWe\tO\nneed\tO\nmore\tO\nevidence\tO\non\tO\nthe\tO\nsafety\tO\nof\tO\nHT\tO\nfor\tO\nmenopausal\tO\nsymptom\tO\ncontrol\tO\n,\tO\nthough\tO\nshort\tO\n-\tO\nterm\tO\nuse\tO\nappears\tO\nto\tO\nbe\tO\nrelatively\tO\nsafe\tO\nfor\tO\nhealthy\tO\nyounger\tO\nwomen\tO\n.\tO\n\nDrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nliver\tI-Disease\ninjury\tI-Disease\n:\tO\nan\tO\nanalysis\tO\nof\tO\n461\tO\nincidences\tO\nsubmitted\tO\nto\tO\nthe\tO\nSpanish\tO\nregistry\tO\nover\tO\na\tO\n10\tO\n-\tO\nyear\tO\nperiod\tO\n.\tO\n\nBACKGROUND\tO\n&\tO\nAIMS\tO\n:\tO\nProgress\tO\nin\tO\nthe\tO\nunderstanding\tO\nof\tO\nsusceptibility\tO\nfactors\tO\nto\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nliver\tI-Disease\ninjury\tI-Disease\n(\tO\nDILI\tB-Disease\n)\tO\nand\tO\noutcome\tO\npredictability\tO\nare\tO\nhampered\tO\nby\tO\nthe\tO\nlack\tO\nof\tO\nsystematic\tO\nprograms\tO\nto\tO\ndetect\tO\nbona\tO\nfide\tO\ncases\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\ncooperative\tO\nnetwork\tO\nwas\tO\ncreated\tO\nin\tO\n1994\tO\nin\tO\nSpain\tO\nto\tO\nidentify\tO\nall\tO\nsuspicions\tO\nof\tO\nDILI\tB-Disease\nfollowing\tO\na\tO\nprospective\tO\nstructured\tO\nreport\tO\nform\tO\n.\tO\n\nThe\tO\nliver\tB-Disease\ndamage\tI-Disease\nwas\tO\ncharacterized\tO\naccording\tO\nto\tO\nhepatocellular\tO\n,\tO\ncholestatic\tB-Disease\n,\tO\nand\tO\nmixed\tO\nlaboratory\tO\ncriteria\tO\nand\tO\nto\tO\nhistologic\tO\ncriteria\tO\nwhen\tO\navailable\tO\n.\tO\n\nFurther\tO\nevaluation\tO\nof\tO\ncausality\tO\nassessment\tO\nwas\tO\ncentrally\tO\nperformed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSince\tO\nApril\tO\n1994\tO\nto\tO\nAugust\tO\n2004\tO\n,\tO\n461\tO\nout\tO\nof\tO\n570\tO\nsubmitted\tO\ncases\tO\n,\tO\ninvolving\tO\n505\tO\ndrugs\tO\n,\tO\nwere\tO\ndeemed\tO\nto\tO\nbe\tO\nrelated\tO\nto\tO\nDILI\tB-Disease\n.\tO\n\nThe\tO\nantiinfective\tO\ngroup\tO\nof\tO\ndrugs\tO\nwas\tO\nthe\tO\nmore\tO\nfrequently\tO\nincriminated\tO\n,\tO\namoxicillin\tB-Chemical\n-\tI-Chemical\nclavulanate\tI-Chemical\naccounting\tO\nfor\tO\nthe\tO\n12\tO\n.\tO\n8\tO\n%\tO\nof\tO\nthe\tO\nwhole\tO\nseries\tO\n.\tO\n\nThe\tO\nhepatocellular\tO\npattern\tO\nof\tO\ndamage\tO\nwas\tO\nthe\tO\nmost\tO\ncommon\tO\n(\tO\n58\tO\n%\tO\n)\tO\n,\tO\nwas\tO\ninversely\tO\ncorrelated\tO\nwith\tO\nage\tO\n(\tO\nP\tO\n<\tO\n.\tO\n0001\tO\n)\tO\n,\tO\nand\tO\nhad\tO\nthe\tO\nworst\tO\noutcome\tO\n(\tO\nCox\tO\nregression\tO\n,\tO\nP\tO\n<\tO\n.\tO\n034\tO\n)\tO\n.\tO\n\nIndeed\tO\n,\tO\nthe\tO\nincidence\tO\nof\tO\nliver\tO\ntransplantation\tO\nand\tO\ndeath\tO\nin\tO\nthis\tO\ngroup\tO\nwas\tO\n11\tO\n.\tO\n7\tO\n%\tO\nif\tO\npatients\tO\nhad\tO\njaundice\tB-Disease\nat\tO\npresentation\tO\n,\tO\nwhereas\tO\nthe\tO\ncorresponding\tO\nfigure\tO\nwas\tO\n3\tO\n.\tO\n8\tO\n%\tO\nin\tO\nnonjaundiced\tO\npatients\tO\n(\tO\nP\tO\n<\tO\n.\tO\n04\tO\n)\tO\n.\tO\n\nFactors\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nfulminant\tB-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\nwere\tO\nfemale\tO\nsex\tO\n(\tO\nOR\tO\n=\tO\n25\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n4\tO\n.\tO\n1\tO\n-\tO\n151\tO\n;\tO\nP\tO\n<\tO\n.\tO\n0001\tO\n)\tO\n,\tO\nhepatocellular\tO\ndamage\tO\n(\tO\nOR\tO\n=\tO\n7\tO\n.\tO\n9\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n1\tO\n.\tO\n6\tO\n-\tO\n37\tO\n;\tO\nP\tO\n<\tO\n.\tO\n009\tO\n)\tO\n,\tO\nand\tO\nhigher\tO\nbaseline\tO\nplasma\tO\nbilirubin\tB-Chemical\nvalue\tO\n(\tO\nOR\tO\n=\tO\n1\tO\n.\tO\n15\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n1\tO\n.\tO\n09\tO\n-\tO\n1\tO\n.\tO\n22\tO\n;\tO\nP\tO\n<\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPatients\tO\nwith\tO\ndrug\tO\n-\tO\ninduced\tO\nhepatocellular\tO\njaundice\tB-Disease\nhave\tO\n11\tO\n.\tO\n7\tO\n%\tO\nchance\tO\nof\tO\nprogressing\tO\nto\tO\ndeath\tO\nor\tO\ntransplantation\tO\n.\tO\n\nAmoxicillin\tB-Chemical\n-\tI-Chemical\nclavulanate\tI-Chemical\nstands\tO\nout\tO\nas\tO\nthe\tO\nmost\tO\ncommon\tO\ndrug\tO\nrelated\tO\nto\tO\nDILI\tB-Disease\n.\tO\n\nMorphological\tO\nevaluation\tO\nof\tO\nthe\tO\neffect\tO\nof\tO\nd\tB-Chemical\n-\tI-Chemical\nribose\tI-Chemical\non\tO\nadriamycin\tB-Chemical\n-\tO\nevoked\tO\ncardiotoxicity\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\ninfluence\tO\nof\tO\nd\tB-Chemical\n-\tI-Chemical\nribose\tI-Chemical\non\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\nmyocardiopathy\tB-Disease\nin\tO\nrats\tO\nwas\tO\nstudied\tO\n.\tO\n\nAdriamycin\tB-Chemical\nin\tO\nthe\tO\ncumulative\tO\ndose\tO\nof\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nevoked\tO\nfully\tO\ndeveloped\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nD\tB-Chemical\n-\tI-Chemical\nribose\tI-Chemical\nin\tO\nthe\tO\nmultiple\tO\ndoses\tO\nof\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\ndid\tO\nnot\tO\ninfluence\tO\nADR\tB-Chemical\ncardiotoxicity\tB-Disease\n.\tO\n\nIn\tO\nvivo\tO\nevidences\tO\nsuggesting\tO\nthe\tO\nrole\tO\nof\tO\noxidative\tO\nstress\tO\nin\tO\npathogenesis\tO\nof\tO\nvancomycin\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n:\tO\nprotection\tO\nby\tO\nerdosteine\tB-Chemical\n.\tO\n\nThe\tO\naims\tO\nof\tO\nthis\tO\nstudy\tO\nwere\tO\nto\tO\nexamine\tO\nvancomycin\tB-Chemical\n(\tO\nVCM\tB-Chemical\n)\tO\n-\tO\ninduced\tO\noxidative\tO\nstress\tO\nthat\tO\npromotes\tO\nproduction\tO\nof\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\n(\tO\nROS\tO\n)\tO\nand\tO\nto\tO\ninvestigate\tO\nthe\tO\nrole\tO\nof\tO\nerdosteine\tB-Chemical\n,\tO\nan\tO\nexpectorant\tO\nagent\tO\n,\tO\nwhich\tO\nhas\tO\nalso\tO\nantioxidant\tO\nproperties\tO\n,\tO\non\tO\nkidney\tO\ntissue\tO\nagainst\tO\nthe\tO\npossible\tO\nVCM\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\nimpairment\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nRats\tO\nwere\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n:\tO\nsham\tO\n,\tO\nVCM\tB-Chemical\nand\tO\nVCM\tB-Chemical\nplus\tO\nerdosteine\tB-Chemical\n.\tO\n\nVCM\tB-Chemical\nwas\tO\nadministrated\tO\nintraperitoneally\tO\n(\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nwith\tO\n200mgkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\ntwice\tO\ndaily\tO\nfor\tO\n7\tO\ndays\tO\n.\tO\n\nErdosteine\tB-Chemical\nwas\tO\nadministered\tO\norally\tO\n.\tO\n\nVCM\tB-Chemical\nadministration\tO\nto\tO\ncontrol\tO\nrats\tO\nsignificantly\tO\nincreased\tO\nrenal\tO\nmalondialdehyde\tB-Chemical\n(\tO\nMDA\tB-Chemical\n)\tO\nand\tO\nurinary\tO\nN\tO\n-\tO\nacetyl\tO\n-\tO\nbeta\tO\n-\tO\nd\tO\n-\tO\nglucosaminidase\tO\n(\tO\nNAG\tO\n,\tO\na\tO\nmarker\tO\nof\tO\nrenal\tB-Disease\ntubular\tI-Disease\ninjury\tI-Disease\n)\tO\nexcretion\tO\nbut\tO\ndecreased\tO\nsuperoxide\tB-Chemical\ndismutase\tO\n(\tO\nSOD\tO\n)\tO\nand\tO\ncatalase\tO\n(\tO\nCAT\tO\n)\tO\nactivities\tO\n.\tO\n\nErdosteine\tB-Chemical\nadministration\tO\nwith\tO\nVCM\tB-Chemical\ninjections\tO\ncaused\tO\nsignificantly\tO\ndecreased\tO\nrenal\tO\nMDA\tB-Chemical\nand\tO\nurinary\tO\nNAG\tO\nexcretion\tO\n,\tO\nand\tO\nincreased\tO\nSOD\tO\nactivity\tO\n,\tO\nbut\tO\nnot\tO\nCAT\tO\nactivity\tO\nin\tO\nrenal\tO\ntissue\tO\nwhen\tO\ncompared\tO\nwith\tO\nVCM\tB-Chemical\nalone\tO\n.\tO\n\nErdosteine\tB-Chemical\nshowed\tO\nhistopathological\tO\nprotection\tO\nagainst\tO\nVCM\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nThere\tO\nwere\tO\na\tO\nsignificant\tO\ndilatation\tO\nof\tO\ntubular\tO\nlumens\tO\n,\tO\nextensive\tO\nepithelial\tO\ncell\tO\nvacuolization\tO\n,\tO\natrophy\tB-Disease\n,\tO\ndesquamation\tB-Disease\n,\tO\nand\tO\nnecrosis\tB-Disease\nin\tO\nVCM\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nmore\tO\nthan\tO\nthose\tO\nof\tO\nthe\tO\ncontrol\tO\nand\tO\nthe\tO\nerdosteine\tB-Chemical\ngroups\tO\n.\tO\n\nErdosteine\tB-Chemical\ncaused\tO\na\tO\nmarked\tO\nreduction\tO\nin\tO\nthe\tO\nextent\tO\nof\tO\ntubular\tO\ndamage\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\noxidative\tO\ntubular\tO\ndamage\tO\nplays\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\nVCM\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\nand\tO\nthe\tO\nmodulation\tO\nof\tO\noxidative\tO\nstress\tO\nwith\tO\nerdosteine\tB-Chemical\nreduces\tO\nthe\tO\nVCM\tB-Chemical\n-\tO\ninduced\tO\nkidney\tB-Disease\ndamage\tI-Disease\nboth\tO\nat\tO\nthe\tO\nbiochemical\tO\nand\tO\nhistological\tO\nlevels\tO\n.\tO\n\nGemfibrozil\tB-Chemical\n-\tO\nlovastatin\tB-Chemical\ntherapy\tO\nfor\tO\nprimary\tO\nhyperlipoproteinemias\tB-Disease\n.\tO\n\nThe\tO\nspecific\tO\naim\tO\nof\tO\nthis\tO\nretrospective\tO\n,\tO\nobservational\tO\nstudy\tO\nwas\tO\nto\tO\nassess\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\n(\tO\n21\tO\nmonths\tO\n/\tO\npatient\tO\n)\tO\n,\tO\nopen\tO\n-\tO\nlabel\tO\n,\tO\ngemfibrozil\tB-Chemical\n-\tO\nlovastatin\tB-Chemical\ntreatment\tO\nin\tO\n80\tO\npatients\tO\nwith\tO\nprimary\tO\nmixed\tO\nhyperlipidemia\tB-Disease\n(\tO\n68\tO\n%\tO\nof\tO\nwhom\tO\nhad\tO\natherosclerotic\tB-Disease\nvascular\tI-Disease\ndisease\tI-Disease\n)\tO\n.\tO\n\nBecause\tO\nideal\tO\nlipid\tO\ntargets\tO\nwere\tO\nnot\tO\nreached\tO\n(\tO\nlow\tO\n-\tO\ndensity\tO\nlipoprotein\tO\n(\tO\nLDL\tO\n)\tO\ncholesterol\tB-Chemical\nless\tO\nthan\tO\n130\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nhigh\tO\n-\tO\ndensity\tO\nlipoprotein\tO\n(\tO\nHDL\tO\n)\tO\ncholesterol\tB-Chemical\ngreater\tO\nthan\tO\n35\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nor\tO\ntotal\tO\ncholesterol\tB-Chemical\n/\tO\nHDL\tO\ncholesterol\tB-Chemical\nless\tO\nthan\tO\n4\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\n)\tO\nwith\tO\ndiet\tO\nplus\tO\na\tO\nsingle\tO\ndrug\tO\n,\tO\ngemfibrozil\tB-Chemical\n(\tO\n1\tO\n.\tO\n2\tO\ng\tO\n/\tO\nday\tO\n)\tO\n-\tO\nlovastatin\tB-Chemical\n(\tO\nprimarily\tO\n20\tO\nor\tO\n40\tO\nmg\tO\n)\tO\ntreatment\tO\nwas\tO\ngiven\tO\n.\tO\n\nFollow\tO\n-\tO\nup\tO\nvisits\tO\nwere\tO\nscheduled\tO\nwith\tO\n2\tO\n-\tO\ndrug\tO\ntherapy\tO\nevery\tO\n6\tO\nto\tO\n8\tO\nweeks\tO\n,\tO\nan\tO\naverage\tO\nof\tO\n10\tO\n.\tO\n3\tO\nvisits\tO\nper\tO\npatient\tO\n,\tO\nwith\tO\n741\tO\nbatteries\tO\nof\tO\n6\tO\nliver\tO\nfunction\tO\ntests\tO\nand\tO\n714\tO\ncreatine\tB-Chemical\nphosphokinase\tO\nlevels\tO\nmeasured\tO\n.\tO\n\nOnly\tO\n1\tO\nof\tO\nthe\tO\n4\tO\n,\tO\n446\tO\nliver\tO\nfunction\tO\ntests\tO\n(\tO\n0\tO\n.\tO\n02\tO\n%\tO\n)\tO\n,\tO\na\tO\ngamma\tO\nglutamyl\tO\ntransferase\tO\n,\tO\nwas\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n3\tO\ntimes\tO\nthe\tO\nupper\tO\nnormal\tO\nlimit\tO\n.\tO\n\nOf\tO\nthe\tO\n714\tO\ncreatine\tB-Chemical\nphosphokinase\tO\nlevels\tO\n,\tO\n9\tO\n%\tO\nwere\tO\nhigh\tO\n;\tO\nonly\tO\n1\tO\n(\tO\n0\tO\n.\tO\n1\tO\n%\tO\n)\tO\nwas\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n3\tO\ntimes\tO\nthe\tO\nupper\tO\nnormal\tO\nlimit\tO\n.\tO\n\nWith\tO\n2\tO\n-\tO\ndrug\tO\ntherapy\tO\n,\tO\nmean\tO\ntotal\tO\ncholesterol\tB-Chemical\ndecreased\tO\n22\tO\n%\tO\nfrom\tO\n255\tO\nto\tO\n200\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\ntriglyceride\tB-Chemical\nlevels\tO\ndecreased\tO\n35\tO\n%\tO\nfrom\tO\n236\tO\nto\tO\n154\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nLDL\tO\ncholesterol\tB-Chemical\ndecreased\tO\n26\tO\n%\tO\nfrom\tO\n176\tO\nto\tO\n131\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nand\tO\nthe\tO\ntotal\tO\ncholesterol\tB-Chemical\n/\tO\nHDL\tO\ncholesterol\tB-Chemical\nratio\tO\ndecreased\tO\n24\tO\n%\tO\nfrom\tO\n7\tO\n.\tO\n1\tO\nto\tO\n5\tO\n.\tO\n4\tO\n,\tO\nall\tO\np\tO\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n0\tO\n.\tO\n0001\tO\n.\tO\n\nMyositis\tB-Disease\n,\tO\nattributable\tO\nto\tO\nthe\tO\ndrug\tO\ncombination\tO\nand\tO\nsymptomatic\tO\nenough\tO\nto\tO\ndiscontinue\tO\nit\tO\n,\tO\noccurred\tO\nin\tO\n3\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nand\tO\nin\tO\n1\tO\n%\tO\nwith\tO\nconcurrent\tO\nhigh\tO\ncreatine\tB-Chemical\nphosphokinase\tO\n(\tO\n769\tO\nU\tO\n/\tO\nliter\tO\n)\tO\n;\tO\nno\tO\npatients\tO\nhad\tO\nrhabdomyolysis\tB-Disease\nor\tO\nmyoglobinuria\tB-Disease\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nDoes\tO\ndomperidone\tB-Chemical\npotentiate\tO\nmirtazapine\tB-Chemical\n-\tO\nassociated\tO\nrestless\tB-Disease\nlegs\tI-Disease\nsyndrome\tI-Disease\n?\tO\n\nThere\tO\nis\tO\nnow\tO\nevidence\tO\nto\tO\nsuggest\tO\na\tO\ncentral\tO\nrole\tO\nfor\tO\nthe\tO\ndopaminergic\tO\nsystem\tO\nin\tO\nrestless\tB-Disease\nlegs\tI-Disease\nsyndrome\tI-Disease\n(\tO\nRLS\tB-Disease\n)\tO\n.\tO\n\nFor\tO\nexample\tO\n,\tO\nthe\tO\nsymptoms\tO\nof\tO\nRLS\tB-Disease\ncan\tO\nbe\tO\ndramatically\tO\nimproved\tO\nby\tO\nlevodopa\tB-Chemical\nand\tO\ndopamine\tB-Chemical\nagonists\tO\n,\tO\nwhereas\tO\ncentral\tO\ndopamine\tB-Chemical\nD2\tO\nreceptor\tO\nantagonists\tO\ncan\tO\ninduce\tO\nor\tO\naggravate\tO\nRLS\tB-Disease\nsymptoms\tO\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthere\tO\nis\tO\nno\tO\nprevious\tO\nreport\tO\nregarding\tO\nwhether\tO\ndomperidone\tB-Chemical\n,\tO\na\tO\nperipheral\tO\ndopamine\tB-Chemical\nD2\tO\nreceptor\tO\nantagonist\tO\n,\tO\ncan\tO\nalso\tO\ninduce\tO\nor\tO\naggravate\tO\nsymptoms\tO\nof\tO\nRLS\tB-Disease\n.\tO\n\nMirtazapine\tB-Chemical\n,\tO\nthe\tO\nfirst\tO\nnoradrenergic\tO\nand\tO\nspecific\tO\nserotonergic\tO\nantidepressant\tO\n(\tO\nNaSSA\tO\n)\tO\n,\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nRLS\tB-Disease\nin\tO\nseveral\tO\nrecent\tO\npublications\tO\n.\tO\n\nThe\tO\nauthors\tO\nreport\tO\nhere\tO\na\tO\ndepressed\tO\npatient\tO\ncomorbid\tO\nwith\tO\npostprandial\tB-Disease\ndyspepsia\tI-Disease\nwho\tO\ndeveloped\tO\nRLS\tB-Disease\nafter\tO\nmirtazapine\tB-Chemical\nhad\tO\nbeen\tO\nadded\tO\nto\tO\nhis\tO\ndomperidone\tB-Chemical\ntherapy\tO\n.\tO\n\nOur\tO\npatient\tO\nstarted\tO\nto\tO\nhave\tO\nsymptoms\tO\nof\tO\nRLS\tB-Disease\nonly\tO\nafter\tO\nhe\tO\nhad\tO\nbeen\tO\ntreated\tO\nwith\tO\nmirtazapine\tB-Chemical\n,\tO\nand\tO\nhis\tO\nRLS\tB-Disease\nsymptoms\tO\nresolved\tO\ncompletely\tO\nupon\tO\ndiscontinuation\tO\nof\tO\nhis\tO\nmirtazapine\tB-Chemical\n.\tO\n\nSuch\tO\na\tO\ntemporal\tO\nrelationship\tO\nbetween\tO\nthe\tO\nuse\tO\nof\tO\nmirtazapine\tB-Chemical\nand\tO\nthe\tO\nsymptoms\tO\nof\tO\nRLS\tB-Disease\nin\tO\nour\tO\npatient\tO\ndid\tO\nnot\tO\nsupport\tO\na\tO\npotentiating\tO\neffect\tO\nof\tO\ndomperione\tB-Chemical\non\tO\nmirtazapine\tB-Chemical\n-\tO\nassociated\tO\nRLS\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nphysicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthe\tO\npossibility\tO\nthat\tO\nmirtazapine\tB-Chemical\ncan\tO\nbe\tO\nassociated\tO\nwith\tO\nRLS\tB-Disease\nin\tO\nsome\tO\nindividuals\tO\n,\tO\nespecially\tO\nthose\tO\nreceiving\tO\nconcomitant\tO\ndopamine\tB-Chemical\nD2\tO\nreceptor\tO\nantagonists\tO\n.\tO\n\nAntiandrogenic\tO\ntherapy\tO\ncan\tO\ncause\tO\ncoronary\tB-Disease\narterial\tI-Disease\ndisease\tI-Disease\n.\tO\n\nAIM\tO\n:\tO\nTo\tO\nstudy\tO\nthe\tO\nchange\tO\nof\tO\nlipid\tO\nmetabolism\tO\nby\tO\nantiandrogen\tO\ntherapy\tO\nin\tO\npatients\tO\nwith\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nWe\tO\nstudied\tO\nwith\tO\na\tO\n2\tO\n.\tO\n5\tO\nyears\tO\nfollow\tO\n-\tO\nup\tO\nthe\tO\nchanges\tO\nin\tO\nplasma\tO\ncholesterols\tB-Chemical\n(\tO\nC\tB-Chemical\n)\tO\n,\tO\ntriglycerides\tB-Chemical\n(\tO\nTG\tB-Chemical\n)\tO\n,\tO\nlipoproteins\tO\n(\tO\nLP\tO\n)\tO\n,\tO\nand\tO\napolipoproteins\tO\n(\tO\nApo\tO\n)\tO\nB\tO\n-\tO\n100\tO\n,\tO\nA\tO\n-\tO\nI\tO\n,\tO\nand\tO\nA\tO\n-\tO\nII\tO\npro\tO\nfi\tO\nles\tO\nin\tO\n24\tO\npatients\tO\nof\tO\nmean\tO\nage\tO\n60\tO\nyears\tO\nwith\tO\nlow\tO\nrisk\tO\nprostate\tB-Disease\ncancer\tI-Disease\n(\tO\nstage\tO\n:\tO\nT1cN0M0\tO\n,\tO\nGleason\tO\nscore\tO\n:\tO\n2\tO\n-\tO\n5\tO\n)\tO\nduring\tO\ntreatment\tO\nwith\tO\ncyproterone\tB-Chemical\nacetate\tI-Chemical\n(\tO\nCPA\tB-Chemical\n)\tO\nwithout\tO\nsurgical\tO\nmanagement\tO\nor\tO\nradiation\tO\ntherapy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSignificant\tO\ndecreases\tO\nof\tO\nHDL\tO\n-\tO\nC\tO\n,\tO\nApo\tO\nA\tO\n-\tO\nI\tO\nand\tO\nApo\tO\nA\tO\n-\tO\nII\tO\nand\tO\nan\tO\nincrease\tO\nof\tO\ntriglyceride\tB-Chemical\nlevels\tO\nin\tO\nVLDL\tO\nwere\tO\ninduced\tO\nby\tO\nCPA\tB-Chemical\n.\tO\n\nAfter\tO\na\tO\nperiod\tO\nof\tO\n2\tO\n.\tO\n5\tO\nyears\tO\non\tO\nCPA\tB-Chemical\ntreatment\tO\n,\tO\nfour\tO\npatients\tO\nout\tO\nof\tO\ntwenty\tO\n-\tO\nfour\tO\nwere\tO\nfound\tO\nto\tO\nbe\tO\naffected\tO\nby\tO\ncoronary\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIschaemic\tO\ncoronary\tB-Disease\narteriosclerosis\tI-Disease\nwith\tO\nan\tO\nincidence\tO\nrate\tO\nof\tO\n16\tO\n.\tO\n6\tO\n%\tO\nas\tO\ncaused\tO\nby\tO\nprolonged\tO\nCPA\tB-Chemical\ntherapy\tO\nis\tO\nmediated\tO\nthrough\tO\nchanges\tO\nin\tO\nHDL\tO\ncholesterol\tB-Chemical\n,\tO\nApo\tO\nA\tO\n-\tO\nI\tO\nand\tO\nApo\tO\nA\tO\n-\tO\nII\tO\npro\tO\nfi\tO\nles\tO\n,\tO\nother\tO\nthan\tO\nthe\tO\nwell\tO\n-\tO\nknown\tO\nhyperglyceridemic\tB-Disease\neffect\tI-Disease\ncaused\tO\nby\tO\nestrogen\tB-Chemical\n.\tO\n\n5\tB-Chemical\n-\tI-Chemical\nFluorouracil\tI-Chemical\ncardiotoxicity\tB-Disease\ninduced\tO\nby\tO\nalpha\tB-Chemical\n-\tI-Chemical\nfluoro\tI-Chemical\n-\tI-Chemical\nbeta\tI-Chemical\n-\tI-Chemical\nalanine\tI-Chemical\n.\tO\n\nCardiotoxicity\tB-Disease\nis\tO\na\tO\nrare\tO\ncomplication\tO\noccurring\tO\nduring\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\ntreatment\tO\nfor\tO\nmalignancies\tB-Disease\n.\tO\n\nWe\tO\nherein\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n70\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n,\tO\nin\tO\nwhom\tO\na\tO\nhigh\tO\nserum\tO\nlevel\tO\nof\tO\nalpha\tB-Chemical\n-\tI-Chemical\nfluoro\tI-Chemical\n-\tI-Chemical\nbeta\tI-Chemical\n-\tI-Chemical\nalanine\tI-Chemical\n(\tO\nFBAL\tB-Chemical\n)\tO\nwas\tO\nobserved\tO\n.\tO\n\nThe\tO\npatient\tO\n,\tO\nwho\tO\nhad\tO\nunresectable\tO\ncolon\tB-Disease\ncancer\tI-Disease\nmetastases\tO\nto\tO\nthe\tO\nliver\tO\nand\tO\nlung\tO\n,\tO\nwas\tO\nreferred\tO\nto\tO\nus\tO\nfor\tO\nchemotherapy\tO\nfrom\tO\nan\tO\naffiliated\tO\nhospital\tO\n;\tO\nhe\tO\nhad\tO\nno\tO\ncardiac\tO\nhistory\tO\n.\tO\n\nAfter\tO\nadmission\tO\n,\tO\nthe\tO\npatient\tO\nreceived\tO\na\tO\ncontinuous\tO\nintravenous\tO\ninfusion\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n(\tO\n1000\tO\nmg\tO\n/\tO\nday\tO\n)\tO\n,\tO\nduring\tO\nwhich\tO\nprecordial\tB-Disease\npain\tI-Disease\nwith\tO\nright\tB-Disease\nbundle\tI-Disease\nbranch\tI-Disease\nblock\tI-Disease\noccurred\tO\nconcomitantly\tO\nwith\tO\na\tO\nhigh\tO\nserum\tO\nFBAL\tB-Chemical\nconcentration\tO\nof\tO\n1955\tO\nng\tO\n/\tO\nml\tO\n.\tO\n\nBoth\tO\nthe\tO\nprecordial\tB-Disease\npain\tI-Disease\nand\tO\nthe\tO\nelectrocardiographic\tO\nchanges\tO\ndisappeared\tO\nspontaneously\tO\nafter\tO\nthe\tO\ndiscontinuation\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n.\tO\n\nAs\tO\nthe\tO\nprecordial\tB-Disease\npain\tI-Disease\nin\tO\nthis\tO\npatient\tO\nwas\tO\nconsidered\tO\nto\tO\nhave\tO\nbeen\tO\ndue\tO\nto\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n,\tO\nthe\tO\nadministration\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nwas\tO\nabandoned\tO\n.\tO\n\nInstead\tO\n,\tO\noral\tO\nadministration\tO\nof\tO\nS\tO\n-\tO\n1\tO\n(\tO\na\tO\nderivative\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\n,\tO\nat\tO\n200\tO\nmg\tO\n/\tO\nday\tO\ntwice\tO\na\tO\nweek\tO\n,\tO\nwas\tO\ninstituted\tO\n,\tO\nbecause\tO\nS\tO\n-\tO\n1\tO\nhas\tO\na\tO\nstrong\tO\ninhibitory\tO\neffect\tO\non\tO\ndihydropyrimidine\tB-Chemical\ndehydrogenase\tO\n,\tO\nwhich\tO\ncatalyzes\tO\nthe\tO\ndegradative\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ninto\tO\nFBAL\tB-Chemical\n.\tO\n\nThe\tO\nserum\tO\nFBAL\tB-Chemical\nconcentration\tO\nsubsequently\tO\ndecreased\tO\nto\tO\n352\tO\nng\tO\n/\tO\nml\tO\n,\tO\nthe\tO\nsame\tO\nas\tO\nthe\tO\nvalue\tO\nmeasured\tO\non\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\nS\tO\n-\tO\n1\tO\nadministration\tO\n.\tO\n\nThereafter\tO\n,\tO\nno\tO\ncardiac\tB-Disease\nsymptoms\tI-Disease\nwere\tO\nobserved\tO\n.\tO\n\nThe\tO\npatient\tO\nachieved\tO\na\tO\npartial\tO\nresponse\tO\n6\tO\nmonths\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\nthe\tO\nS\tO\n-\tO\n1\tO\ntreatment\tO\n.\tO\n\nThe\tO\nexperience\tO\nof\tO\nthis\tO\ncase\tO\n,\tO\ntogether\tO\nwith\tO\na\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\n,\tO\nsuggests\tO\nthat\tO\nFBAL\tB-Chemical\nis\tO\nrelated\tO\nto\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nS\tO\n-\tO\n1\tO\nmay\tO\nbe\tO\nadministered\tO\nsafely\tO\nto\tO\npatients\tO\nwith\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nHepatocellular\tB-Disease\ncarcinoma\tI-Disease\nin\tO\nFanconi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nanemia\tI-Disease\ntreated\tO\nwith\tO\nandrogen\tB-Chemical\nand\tO\ncorticosteroid\tB-Chemical\n.\tO\n\nThe\tO\ncase\tO\nof\tO\nan\tO\n11\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nis\tO\nreported\tO\nwho\tO\nwas\tO\nknown\tO\nto\tO\nhave\tO\nFanconi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nanemia\tI-Disease\nfor\tO\n3\tO\nyears\tO\nand\tO\nwas\tO\ntreated\tO\nwith\tO\nandrogens\tB-Chemical\n,\tO\ncorticosteroids\tB-Chemical\nand\tO\ntransfusions\tO\n.\tO\n\nTwo\tO\nweeks\tO\nbefore\tO\nhis\tO\ndeath\tO\nhe\tO\nwas\tO\nreadmitted\tO\nbecause\tO\nof\tO\naplastic\tO\ncrisis\tO\nwith\tO\nsepticemia\tB-Disease\nand\tO\nmarked\tO\nabnormalities\tO\nin\tO\nliver\tO\nfunction\tO\nand\tO\ndied\tO\nof\tO\nhemorrhagic\tB-Disease\nbronchopneumonia\tI-Disease\n.\tO\n\nAt\tO\nautopsy\tO\npeliosis\tB-Disease\nand\tO\nmultiple\tO\nhepatic\tB-Disease\ntumors\tI-Disease\nwere\tO\nfound\tO\nwhich\tO\nhistologically\tO\nproved\tO\nto\tO\nbe\tO\nwell\tO\n-\tO\ndifferentiated\tO\nhepatocellular\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nThis\tO\ncase\tO\ncontributes\tO\nto\tO\nthe\tO\nprevious\tO\nobservations\tO\nthat\tO\nnon\tO\n-\tO\nmetastasizing\tO\nhepatic\tB-Disease\nneoplasms\tI-Disease\nand\tO\npeliosis\tB-Disease\ncan\tO\ndevelop\tO\nin\tO\npatients\tO\nwith\tO\nandrogen\tB-Chemical\n-\tO\nand\tO\ncorticosteroid\tB-Chemical\n-\tO\ntreated\tO\nFanconi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nanemia\tI-Disease\n.\tO\n\nThe\tO\ninfluence\tO\nof\tO\nthe\tO\ntime\tO\ninterval\tO\nbetween\tO\nmonoHER\tB-Chemical\nand\tO\ndoxorubicin\tB-Chemical\nadministration\tO\non\tO\nthe\tO\nprotection\tO\nagainst\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nDespite\tO\nits\tO\nwell\tO\n-\tO\nknown\tO\ncardiotoxicity\tB-Disease\n,\tO\nthe\tO\nanthracyclin\tO\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\ncontinues\tO\nto\tO\nbe\tO\nan\tO\neffective\tO\nand\tO\nwidely\tO\nused\tO\nchemotherapeutic\tO\nagent\tO\n.\tO\n\nDOX\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\ndamage\tI-Disease\npresumably\tO\nresults\tO\nfrom\tO\nthe\tO\nformation\tO\nof\tO\nfree\tO\nradicals\tO\nby\tO\nDOX\tB-Chemical\n.\tO\n\nReactive\tO\noxygen\tB-Chemical\nspecies\tO\nparticularly\tO\naffect\tO\nthe\tO\ncardiac\tO\nmyocytes\tO\nbecause\tO\nthese\tO\ncells\tO\nseem\tO\nto\tO\nhave\tO\na\tO\nrelatively\tO\npoor\tO\nantioxidant\tO\ndefense\tO\nsystem\tO\n.\tO\n\nThe\tO\nsemisynthetic\tO\nflavonoid\tB-Chemical\nmonohydroxyethylrutoside\tB-Chemical\n(\tO\nmonoHER\tB-Chemical\n)\tO\nshowed\tO\ncardioprotection\tO\nagainst\tO\nDOX\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nthrough\tO\nits\tO\nradical\tO\nscavenging\tO\nand\tO\niron\tB-Chemical\nchelating\tO\nproperties\tO\n.\tO\n\nBecause\tO\nof\tO\nthe\tO\nrelatively\tO\nshort\tO\nfinal\tO\nhalf\tO\n-\tO\nlife\tO\nof\tO\nmonoHER\tB-Chemical\n(\tO\nabout\tO\n30\tO\nmin\tO\n)\tO\n,\tO\nit\tO\nis\tO\nexpected\tO\nthat\tO\nthe\tO\ntime\tO\ninterval\tO\nbetween\tO\nmonoHER\tB-Chemical\nand\tO\nDOX\tB-Chemical\nmight\tO\nbe\tO\nof\tO\ninfluence\tO\non\tO\nthe\tO\ncardioprotective\tO\neffect\tO\nof\tO\nmonoHER\tB-Chemical\n.\tO\n\nTherefore\tO\n,\tO\nthe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthis\tO\npossible\tO\neffect\tO\n.\tO\n\nMETHODS\tO\n:\tO\nSix\tO\ngroups\tO\nof\tO\n6\tO\nBALB\tO\n/\tO\nc\tO\nmice\tO\nwere\tO\ntreated\tO\nwith\tO\nsaline\tO\n,\tO\nDOX\tB-Chemical\nalone\tO\nor\tO\nDOX\tB-Chemical\n(\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\npreceded\tO\nby\tO\nmonoHER\tB-Chemical\n(\tO\n500\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nwith\tO\nan\tO\ninterval\tO\nof\tO\n10\tO\n,\tO\n30\tO\n,\tO\n60\tO\nor\tO\n120\tO\nmin\tO\n.\tO\n\nAfter\tO\na\tO\n6\tO\n-\tO\nweek\tO\ntreatment\tO\nperiod\tO\nand\tO\nadditional\tO\nobservation\tO\nfor\tO\n2\tO\nweeks\tO\n,\tO\nthe\tO\nmice\tO\nwere\tO\nsacrificed\tO\n.\tO\n\nTheir\tO\ncardiac\tO\ntissues\tO\nwere\tO\nprocessed\tO\nfor\tO\nlight\tO\nmicroscopy\tO\n,\tO\nafter\tO\nwhich\tO\ncardiomyocyte\tB-Disease\ndamage\tI-Disease\nwas\tO\nevaluated\tO\naccording\tO\nto\tO\nBillingham\tO\n(\tO\nin\tO\nCancer\tB-Disease\nTreat\tO\nRep\tO\n62\tO\n(\tO\n6\tO\n)\tO\n:\tO\n865\tO\n-\tO\n872\tO\n,\tO\n1978\tO\n)\tO\n.\tO\n\nMicroscopic\tO\nevaluation\tO\nrevealed\tO\nthat\tO\ntreatment\tO\nwith\tO\nDOX\tB-Chemical\nalone\tO\ninduced\tO\nsignificant\tO\ncardiac\tB-Disease\ndamage\tI-Disease\nin\tO\ncomparison\tO\nto\tO\nthe\tO\nsaline\tO\ncontrol\tO\ngroup\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nnumber\tO\nof\tO\ndamaged\tO\ncardiomyocytes\tO\nwas\tO\n9\tO\n.\tO\n6\tO\n-\tO\nfold\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n4\tO\n.\tO\n4\tO\n-\tO\n21\tO\n.\tO\n0\tO\n)\tO\nhigher\tO\nin\tO\nmice\tO\ntreated\tO\nwith\tO\nDOX\tB-Chemical\nalone\tO\nthan\tO\nthat\tO\nin\tO\nanimals\tO\nof\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nThe\tO\nratio\tO\nof\tO\naberrant\tO\ncardiomyocytes\tO\nin\tO\nmice\tO\ntreated\tO\nwith\tO\nDOX\tB-Chemical\npreceded\tO\nby\tO\nmonoHER\tB-Chemical\nand\tO\nthose\tO\nin\tO\nmice\tO\ntreated\tO\nwith\tO\nsaline\tO\nranged\tO\nfrom\tO\n1\tO\n.\tO\n6\tO\nto\tO\n2\tO\n.\tO\n8\tO\n(\tO\nmean\tO\n2\tO\n.\tO\n2\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n2\tO\n-\tO\n4\tO\n.\tO\n1\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n019\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nprotective\tO\neffect\tO\nby\tO\nadding\tO\nmonoHER\tB-Chemical\nbefore\tO\nDOX\tB-Chemical\nled\tO\nto\tO\na\tO\nsignificant\tO\n4\tO\n.\tO\n4\tO\n-\tO\nfold\tO\nreduction\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n2\tO\n.\tO\n3\tO\n-\tO\n8\tO\n.\tO\n2\tO\n)\tO\nof\tO\nabnormal\tO\ncardiomyocytes\tO\n.\tO\n\nThis\tO\nprotective\tO\neffect\tO\ndid\tO\nnot\tO\ndepend\tO\non\tO\nthe\tO\ntime\tO\ninterval\tO\nbetween\tO\nmonoHER\tB-Chemical\nand\tO\nDOX\tB-Chemical\nadministration\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n345\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nin\tO\nan\tO\noutpatient\tO\nclinical\tO\nsetting\tO\nmonoHER\tB-Chemical\nmay\tO\nbe\tO\nadministered\tO\nshortly\tO\nbefore\tO\nDOX\tB-Chemical\n.\tO\n\nClinical\tO\nevaluation\tO\nof\tO\nadverse\tO\neffects\tO\nduring\tO\nbepridil\tB-Chemical\nadministration\tO\nfor\tO\natrial\tB-Disease\nfibrillation\tI-Disease\nand\tI-Disease\nflutter\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nBepridil\tB-Chemical\nhydrochloride\tI-Chemical\n(\tO\nBpd\tB-Chemical\n)\tO\nhas\tO\nattracted\tO\nattention\tO\nas\tO\nan\tO\neffective\tO\ndrug\tO\nfor\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n(\tO\nAF\tB-Disease\n)\tO\nand\tO\natrial\tB-Disease\nflutter\tI-Disease\n(\tO\nAFL\tB-Disease\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nserious\tO\nadverse\tO\neffects\tO\n,\tO\nincluding\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\nTdp\tB-Disease\n)\tO\n,\tO\nhave\tO\nbeen\tO\nreported\tO\n.\tO\n\nMETHODS\tO\nAND\tO\nRESULTS\tO\n:\tO\nAdverse\tO\neffects\tO\nof\tO\nBpd\tB-Chemical\nrequiring\tO\ndiscontinuation\tO\nof\tO\ntreatment\tO\nwere\tO\nevaluated\tO\n.\tO\n\nBpd\tB-Chemical\nwas\tO\nadministered\tO\nto\tO\n459\tO\npatients\tO\n(\tO\n361\tO\nmales\tO\n,\tO\n63\tO\n+\tO\n/\tO\n-\tO\n12\tO\nyears\tO\nold\tO\n)\tO\ncomprising\tO\n378\tO\nAF\tB-Disease\nand\tO\n81\tO\nAFL\tB-Disease\ncases\tO\n.\tO\n\nMean\tO\nleft\tO\nventricular\tO\nejection\tO\nfraction\tO\nand\tO\natrial\tO\ndimension\tO\n(\tO\nLAD\tO\n)\tO\nwere\tO\n66\tO\n+\tO\n/\tO\n-\tO\n11\tO\n%\tO\nand\tO\n40\tO\n+\tO\n/\tO\n-\tO\n6\tO\nmm\tO\n,\tO\nrespectively\tO\n.\tO\n\nAdverse\tO\neffects\tO\nwere\tO\nobserved\tO\nin\tO\n19\tO\npatients\tO\n(\tO\n4\tO\n%\tO\n)\tO\nduring\tO\nan\tO\naverage\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n20\tO\nmonths\tO\n.\tO\n\nThere\tO\nwas\tO\nmarked\tO\nQT\tB-Disease\nprolongation\tI-Disease\ngreater\tO\nthan\tO\n0\tO\n.\tO\n55\tO\ns\tO\nin\tO\n13\tO\npatients\tO\n,\tO\nbradycardia\tB-Disease\nless\tO\nthan\tO\n40\tO\nbeats\tO\n/\tO\nmin\tO\nin\tO\n6\tO\npatients\tO\n,\tO\ndizziness\tB-Disease\nand\tO\ngeneral\tO\nfatigue\tB-Disease\nin\tO\n1\tO\npatient\tO\neach\tO\n.\tO\n\nIn\tO\n4\tO\nof\tO\n13\tO\npatients\tO\nwith\tO\nQT\tB-Disease\nprolongation\tI-Disease\n,\tO\nTdp\tB-Disease\noccurred\tO\n.\tO\n\nThe\tO\nmajor\tO\ntriggering\tO\nfactors\tO\nof\tO\nTdp\tB-Disease\nwere\tO\nhypokalemia\tB-Disease\nand\tO\nsudden\tO\ndecrease\tO\nin\tO\nheart\tO\nrate\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\ndifferences\tO\nin\tO\nthe\tO\nclinical\tO\nbackgrounds\tO\nof\tO\nthe\tO\npatients\tO\nwith\tO\nand\tO\nwithout\tO\nTdp\tB-Disease\nother\tO\nthan\tO\nLAD\tO\nand\tO\nage\tO\n,\tO\nwhich\tO\nwere\tO\nlarger\tO\nand\tO\nolder\tO\nin\tO\nthe\tO\npatients\tO\nwith\tO\nTdp\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nCareful\tO\nobservation\tO\nof\tO\nserum\tO\npotassium\tB-Chemical\nconcentration\tO\nand\tO\nthe\tO\nECG\tO\nshould\tO\nalways\tO\nbe\tO\ndone\tO\nduring\tO\nBpd\tB-Chemical\nadministration\tO\n,\tO\nparticularly\tO\nin\tO\nelderly\tO\npatients\tO\n.\tO\n\nEnhanced\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\nin\tO\ntransgenic\tO\nrats\tO\nwith\tO\nlow\tO\nbrain\tO\nangiotensinogen\tO\n.\tO\n\nWe\tO\nhave\tO\npreviously\tO\nshown\tO\nthat\tO\na\tO\npermanent\tO\ndeficiency\tO\nin\tO\nthe\tO\nbrain\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\n(\tO\nRAS\tO\n)\tO\nmay\tO\nincrease\tO\nthe\tO\nsensitivity\tO\nof\tO\nthe\tO\nbaroreflex\tO\ncontrol\tO\nof\tO\nheart\tO\nrate\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\nwe\tO\naimed\tO\nat\tO\nstudying\tO\nthe\tO\ninvolvement\tO\nof\tO\nthe\tO\nbrain\tO\nRAS\tO\nin\tO\nthe\tO\ncardiac\tO\nreactivity\tO\nto\tO\nthe\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\n(\tO\nbeta\tO\n-\tO\nAR\tO\n)\tO\nagonist\tO\nisoproterenol\tB-Chemical\n(\tO\nIso\tB-Chemical\n)\tO\n.\tO\n\nTransgenic\tO\nrats\tO\nwith\tO\nlow\tO\nbrain\tO\nangiotensinogen\tO\n(\tO\nTGR\tO\n)\tO\nwere\tO\nused\tO\n.\tO\n\nIn\tO\nisolated\tO\nhearts\tO\n,\tO\nIso\tB-Chemical\ninduced\tO\na\tO\nsignificantly\tO\ngreater\tO\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\n(\tO\nLV\tO\n)\tO\npressure\tO\nand\tO\nmaximal\tO\ncontraction\tO\n(\tO\n+\tO\ndP\tO\n/\tO\ndt\tO\n(\tO\nmax\tO\n)\tO\n)\tO\nin\tO\nthe\tO\nTGR\tO\nthan\tO\nin\tO\nthe\tO\nSprague\tO\n-\tO\nDawley\tO\n(\tO\nSD\tO\n)\tO\nrats\tO\n.\tO\n\nLV\tB-Disease\nhypertrophy\tI-Disease\ninduced\tO\nby\tO\nIso\tB-Chemical\ntreatment\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nin\tO\nTGR\tO\nthan\tO\nin\tO\nSD\tO\nrats\tO\n(\tO\nin\tO\ng\tO\nLV\tO\nwt\tO\n/\tO\n100\tO\ng\tO\nbody\tO\nwt\tO\n,\tO\n0\tO\n.\tO\n28\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n004\tO\nvs\tO\n.\tO\n0\tO\n.\tO\n24\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n004\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nThe\tO\ngreater\tO\nLV\tB-Disease\nhypertrophy\tI-Disease\nin\tO\nTGR\tO\nrats\tO\nwas\tO\nassociated\tO\nwith\tO\nmore\tO\npronounced\tO\ndownregulation\tO\nof\tO\nbeta\tO\n-\tO\nAR\tO\nand\tO\nupregulation\tO\nof\tO\nLV\tO\nbeta\tO\n-\tO\nAR\tO\nkinase\tO\n-\tO\n1\tO\nmRNA\tO\nlevels\tO\ncompared\tO\nwith\tO\nthose\tO\nin\tO\nSD\tO\nrats\tO\n.\tO\n\nThe\tO\ndecrease\tO\nin\tO\nthe\tO\nheart\tO\nrate\tO\n(\tO\nHR\tO\n)\tO\ninduced\tO\nby\tO\nthe\tO\nbeta\tO\n-\tO\nAR\tO\nantagonist\tO\nmetoprolol\tB-Chemical\nin\tO\nconscious\tO\nrats\tO\nwas\tO\nsignificantly\tO\nattenuated\tO\nin\tO\nTGR\tO\ncompared\tO\nwith\tO\nSD\tO\nrats\tO\n(\tO\n-\tO\n9\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n7\tO\n%\tO\nvs\tO\n.\tO\n-\tO\n18\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n5\tO\n%\tO\n)\tO\n,\tO\nwhereas\tO\nthe\tO\neffect\tO\nof\tO\nparasympathetic\tO\nblockade\tO\nby\tO\natropine\tB-Chemical\non\tO\nHR\tO\nwas\tO\nsimilar\tO\nin\tO\nboth\tO\nstrains\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nTGR\tO\nare\tO\nmore\tO\nsensitive\tO\nto\tO\nbeta\tO\n-\tO\nAR\tO\nagonist\tO\n-\tO\ninduced\tO\ncardiac\tB-Disease\ninotropic\tI-Disease\nresponse\tO\nand\tO\nhypertrophy\tB-Disease\n,\tO\npossibly\tO\ndue\tO\nto\tO\nchronically\tO\nlow\tO\nsympathetic\tO\noutflow\tO\ndirected\tO\nto\tO\nthe\tO\nheart\tO\n.\tO\n\nDrug\tO\n-\tO\ninduced\tO\nlong\tB-Disease\nQT\tI-Disease\nsyndrome\tI-Disease\nin\tO\ninjection\tO\ndrug\tO\nusers\tO\nreceiving\tO\nmethadone\tB-Chemical\n:\tO\nhigh\tO\nfrequency\tO\nin\tO\nhospitalized\tO\npatients\tO\nand\tO\nrisk\tO\nfactors\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nDrug\tO\n-\tO\ninduced\tO\nlong\tB-Disease\nQT\tI-Disease\nsyndrome\tI-Disease\nis\tO\na\tO\nserious\tO\nadverse\tO\ndrug\tO\nreaction\tO\n.\tO\n\nMethadone\tB-Chemical\nprolongs\tO\nthe\tO\nQT\tO\ninterval\tO\nin\tO\nvitro\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nIn\tO\nthe\tO\ninpatient\tO\nsetting\tO\n,\tO\nthe\tO\nfrequency\tO\nof\tO\nQT\tB-Disease\ninterval\tI-Disease\nprolongation\tI-Disease\nwith\tO\nmethadone\tB-Chemical\ntreatment\tO\n,\tO\nits\tO\ndose\tO\ndependence\tO\n,\tO\nand\tO\nthe\tO\nimportance\tO\nof\tO\ncofactors\tO\nsuch\tO\nas\tO\ndrug\tO\n-\tO\ndrug\tO\ninteractions\tO\nremain\tO\nunknown\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nperformed\tO\na\tO\nsystematic\tO\n,\tO\nretrospective\tO\nstudy\tO\ncomparing\tO\nactive\tO\nor\tO\nformer\tO\nintravenous\tO\ndrug\tO\nusers\tO\nreceiving\tO\nmethadone\tB-Chemical\nand\tO\nthose\tO\nnot\tO\nreceiving\tO\nmethadone\tB-Chemical\namong\tO\nall\tO\npatients\tO\nhospitalized\tO\nover\tO\na\tO\n5\tO\n-\tO\nyear\tO\nperiod\tO\nin\tO\na\tO\ntertiary\tO\ncare\tO\nhospital\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n167\tO\npatients\tO\nreceiving\tO\nmethadone\tB-Chemical\nfulfilled\tO\nthe\tO\ninclusion\tO\ncriteria\tO\nand\tO\nwere\tO\ncompared\tO\nwith\tO\na\tO\ncontrol\tO\ngroup\tO\nof\tO\n80\tO\ninjection\tO\ndrug\tO\nusers\tO\nnot\tO\nreceiving\tO\nmethadone\tB-Chemical\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nmethadone\tB-Chemical\ndose\tO\n,\tO\n15\tO\ndemographic\tO\n,\tO\nbiological\tO\n,\tO\nand\tO\npharmacological\tO\nvariables\tO\nwere\tO\nconsidered\tO\nas\tO\npotential\tO\nrisk\tO\nfactors\tO\nfor\tO\nQT\tB-Disease\nprolongation\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nAmong\tO\n167\tO\nmethadone\tB-Chemical\nmaintenance\tO\npatients\tO\n,\tO\nthe\tO\nprevalence\tO\nof\tO\nQTc\tO\nprolongation\tO\nto\tO\n0\tO\n.\tO\n50\tO\nsecond\tO\n(\tO\n(\tO\n1\tO\n/\tO\n2\tO\n)\tO\n)\tO\nor\tO\nlonger\tO\nwas\tO\n16\tO\n.\tO\n2\tO\n%\tO\ncompared\tO\nwith\tO\n0\tO\n%\tO\nin\tO\n80\tO\ncontrol\tO\nsubjects\tO\n.\tO\n\nSix\tO\npatients\tO\n(\tO\n3\tO\n.\tO\n6\tO\n%\tO\n)\tO\nin\tO\nthe\tO\nmethadone\tB-Chemical\ngroup\tO\npresented\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n.\tO\n\nQTc\tO\nlength\tO\nwas\tO\nweakly\tO\nbut\tO\nsignificantly\tO\nassociated\tO\nwith\tO\nmethadone\tB-Chemical\ndaily\tO\ndose\tO\n(\tO\nSpearman\tO\nrank\tO\ncorrelation\tO\ncoefficient\tO\n,\tO\n0\tO\n.\tO\n20\tO\n;\tO\nP\tO\n<\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nMultivariate\tO\nregression\tO\nanalysis\tO\nallowed\tO\nattribution\tO\nof\tO\n31\tO\n.\tO\n8\tO\n%\tO\nof\tO\nQTc\tO\nvariability\tO\nto\tO\nmethadone\tB-Chemical\ndose\tO\n,\tO\ncytochrome\tO\nP\tO\n-\tO\n450\tO\n3A4\tO\ndrug\tO\n-\tO\ndrug\tO\ninteractions\tO\n,\tO\nhypokalemia\tB-Disease\n,\tO\nand\tO\naltered\tO\nliver\tO\nfunction\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nQT\tB-Disease\ninterval\tI-Disease\nprolongation\tI-Disease\nin\tO\nmethadone\tB-Chemical\nmaintenance\tO\npatients\tO\nhospitalized\tO\nin\tO\na\tO\ntertiary\tO\ncare\tO\ncenter\tO\nis\tO\na\tO\nfrequent\tO\nfinding\tO\n.\tO\n\nMethadone\tB-Chemical\ndose\tO\n,\tO\npresence\tO\nof\tO\ncytochrome\tO\nP\tO\n-\tO\n450\tO\n3A4\tO\ninhibitors\tO\n,\tO\npotassium\tB-Chemical\nlevel\tO\n,\tO\nand\tO\nliver\tO\nfunction\tO\ncontribute\tO\nto\tO\nQT\tB-Disease\nprolongation\tI-Disease\n.\tO\n\nLong\tB-Disease\nQT\tI-Disease\nsyndrome\tI-Disease\ncan\tO\noccur\tO\nwith\tO\nlow\tO\ndoses\tO\nof\tO\nmethadone\tB-Chemical\n.\tO\n\nMechanisms\tO\nof\tO\nhypertension\tB-Disease\ninduced\tO\nby\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\ndeficiency\tO\n:\tO\nfocus\tO\non\tO\nvenous\tO\nfunction\tO\n.\tO\n\nLoss\tO\nof\tO\nendothelial\tO\ncell\tO\n-\tO\nderived\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\nin\tO\nhypertension\tB-Disease\nis\tO\na\tO\nhallmark\tO\nof\tO\narterial\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nExperimental\tO\nhypertension\tB-Disease\ncreated\tO\nby\tO\nthe\tO\nremoval\tO\nof\tO\nNO\tB-Chemical\n,\tO\nhowever\tO\n,\tO\ninvolves\tO\nmechanisms\tO\nin\tO\naddition\tO\nto\tO\ndecreased\tO\narterial\tO\nvasodilator\tO\nactivity\tO\n.\tO\n\nThese\tO\ninclude\tO\naugmented\tO\nendothelin\tO\n-\tO\n1\tO\n(\tO\nET\tO\n-\tO\n1\tO\n)\tO\nrelease\tO\n,\tO\nincreased\tO\nsympathetic\tO\nnervous\tO\nsystem\tO\nactivity\tO\n,\tO\nand\tO\nelevated\tO\ntissue\tO\noxidative\tO\nstress\tO\n.\tO\n\nWe\tO\nhypothesized\tO\nthat\tO\nincreased\tO\nvenous\tO\nsmooth\tO\nmuscle\tO\n(\tO\nvenomotor\tO\n)\tO\ntone\tO\nplays\tO\na\tO\nrole\tO\nin\tO\nNomega\tB-Chemical\n-\tI-Chemical\nnitro\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n(\tO\nLNNA\tB-Chemical\n)\tO\nhypertension\tB-Disease\nthrough\tO\nthese\tO\nmechanisms\tO\n.\tO\n\nRats\tO\nwere\tO\ntreated\tO\nwith\tO\nthe\tO\nNO\tB-Chemical\nsynthase\tO\ninhibitor\tO\nLNNA\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\ng\tO\n/\tO\nL\tO\nin\tO\ndrinking\tO\nwater\tO\n)\tO\nfor\tO\n2\tO\nweeks\tO\n.\tO\n\nMean\tO\narterial\tO\npressure\tO\nof\tO\nconscious\tO\nrats\tO\nwas\tO\n119\tO\n+\tO\n/\tO\n-\tO\n2\tO\nmm\tO\nHg\tO\nin\tO\ncontrol\tO\nand\tO\n194\tO\n+\tO\n/\tO\n-\tO\n5\tO\nmm\tO\nHg\tO\nin\tO\nLNNA\tB-Chemical\nrats\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCarotid\tO\narteries\tO\nand\tO\nvena\tO\ncava\tO\nwere\tO\nremoved\tO\nfor\tO\nmeasurement\tO\nof\tO\nisometric\tO\ncontraction\tO\n.\tO\n\nMaximal\tO\ncontraction\tO\nto\tO\nnorepinephrine\tB-Chemical\nwas\tO\nmodestly\tO\nreduced\tO\nin\tO\narteries\tO\nfrom\tO\nLNNA\tB-Chemical\ncompared\tO\nwith\tO\ncontrol\tO\nrats\tO\nwhereas\tO\nthe\tO\nmaximum\tO\ncontraction\tO\nto\tO\nET\tO\n-\tO\n1\tO\nwas\tO\nsignificantly\tO\nreduced\tO\n(\tO\n54\tO\n%\tO\ncontrol\tO\n)\tO\n.\tO\n\nMaximum\tO\ncontraction\tO\nof\tO\nvena\tO\ncava\tO\nto\tO\nnorepinephrine\tB-Chemical\n(\tO\n37\tO\n%\tO\ncontrol\tO\n)\tO\nalso\tO\nwas\tO\nreduced\tO\nbut\tO\nno\tO\nchange\tO\nin\tO\nresponse\tO\nto\tO\nET\tO\n-\tO\n1\tO\nwas\tO\nobserved\tO\n.\tO\n\nMean\tO\ncirculatory\tO\nfilling\tO\npressure\tO\n,\tO\nan\tO\nin\tO\nvivo\tO\nmeasure\tO\nof\tO\nvenomotor\tO\ntone\tO\n,\tO\nwas\tO\nnot\tO\nelevated\tO\nin\tO\nLNNA\tB-Chemical\nhypertension\tB-Disease\nat\tO\n1\tO\nor\tO\n2\tO\nweeks\tO\nafter\tO\nLNNA\tB-Chemical\n.\tO\n\nThe\tO\nsuperoxide\tB-Chemical\nscavenger\tO\ntempol\tB-Chemical\n(\tO\n30\tO\n,\tO\n100\tO\n,\tO\nand\tO\n300\tO\nmicromol\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n,\tO\nIV\tO\n)\tO\ndid\tO\nnot\tO\nchange\tO\narterial\tO\npressure\tO\nin\tO\ncontrol\tO\nrats\tO\nbut\tO\ncaused\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\ndecrease\tO\nin\tO\nLNNA\tB-Chemical\nrats\tO\n(\tO\n-\tO\n18\tO\n+\tO\n/\tO\n-\tO\n8\tO\n,\tO\n-\tO\n26\tO\n+\tO\n/\tO\n-\tO\n15\tO\n,\tO\nand\tO\n-\tO\n54\tO\n+\tO\n/\tO\n-\tO\n11\tO\nmm\tO\nHg\tO\n)\tO\n.\tO\n\nSimilarly\tO\n,\tO\nganglionic\tO\nblockade\tO\nwith\tO\nhexamethonium\tB-Chemical\ncaused\tO\na\tO\nsignificantly\tO\ngreater\tO\nfall\tO\nin\tO\nLNNA\tB-Chemical\nhypertensive\tB-Disease\nrats\tO\n(\tO\n76\tO\n+\tO\n/\tO\n-\tO\n9\tO\nmm\tO\nHg\tO\n)\tO\ncompared\tO\nwith\tO\ncontrol\tO\nrats\tO\n(\tO\n35\tO\n+\tO\n/\tO\n-\tO\n10\tO\nmm\tO\nHg\tO\n)\tO\n.\tO\n\nCarotid\tO\narteries\tO\n,\tO\nvena\tO\ncava\tO\n,\tO\nand\tO\nsympathetic\tO\nganglia\tO\nfrom\tO\nLNNA\tB-Chemical\nrats\tO\nhad\tO\nhigher\tO\nbasal\tO\nlevels\tO\nof\tO\nsuperoxide\tB-Chemical\ncompared\tO\nwith\tO\nthose\tO\nfrom\tO\ncontrol\tO\nrats\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\nwhile\tO\nNO\tB-Chemical\ndeficiency\tO\nincreases\tO\noxidative\tO\nstress\tO\nand\tO\nsympathetic\tO\nactivity\tO\nin\tO\nboth\tO\narterial\tO\nand\tO\nvenous\tO\nvessels\tO\n,\tO\nthe\tO\nimpact\tO\non\tO\nveins\tO\ndoes\tO\nnot\tO\nmake\tO\na\tO\nmajor\tO\ncontribution\tO\nto\tO\nthis\tO\nform\tO\nof\tO\nhypertension\tB-Disease\n.\tO\n\nAssociation\tO\nof\tO\nDRD2\tO\npolymorphisms\tO\nand\tO\nchlorpromazine\tB-Chemical\n-\tO\ninduced\tO\nextrapyramidal\tB-Disease\nsyndrome\tI-Disease\nin\tO\nChinese\tO\nschizophrenic\tB-Disease\npatients\tO\n.\tO\n\nAIM\tO\n:\tO\nExtrapyramidal\tB-Disease\nsyndrome\tI-Disease\n(\tO\nEPS\tB-Disease\n)\tO\nis\tO\nmost\tO\ncommonly\tO\naffected\tO\nby\tO\ntypical\tO\nantipsychotic\tO\ndrugs\tO\nthat\tO\nhave\tO\na\tO\nhigh\tO\naffinity\tO\nwith\tO\nthe\tO\nD2\tO\nreceptor\tO\n.\tO\n\nRecently\tO\n,\tO\nmany\tO\nresearch\tO\ngroups\tO\nhave\tO\nreported\tO\non\tO\nthe\tO\npositive\tO\nrelationship\tO\nbetween\tO\nthe\tO\ngenetic\tO\nvariations\tO\nin\tO\nthe\tO\nDRD2\tO\ngene\tO\nand\tO\nthe\tO\ntherapeutic\tO\nresponse\tO\nin\tO\nschizophrenia\tB-Disease\npatients\tO\nas\tO\na\tO\nresult\tO\nof\tO\nthe\tO\nrole\tO\nof\tO\nvariations\tO\nin\tO\nthe\tO\nreceptor\tO\nin\tO\nmodulating\tO\nreceptor\tO\nexpression\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\nevaluate\tO\nthe\tO\nrole\tO\nDRD2\tO\nplays\tO\nin\tO\nchlorpromazine\tB-Chemical\n-\tO\ninduced\tO\nEPS\tB-Disease\nin\tO\nschizophrenic\tB-Disease\npatients\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nidentified\tO\nseven\tO\nSNP\tO\n(\tO\nsingle\tO\nnucleotide\tO\npolymorphism\tO\n)\tO\n(\tO\n-\tO\n141Cins\tO\n>\tO\ndel\tO\n,\tO\nTaqIB\tO\n,\tO\nTaqID\tO\n,\tO\nSer311Cys\tO\n,\tO\nrs6275\tO\n,\tO\nrs6277\tO\nand\tO\nTaqIA\tO\n)\tO\nin\tO\nthe\tO\nDRD2\tO\ngene\tO\nin\tO\n146\tO\nschizophrenic\tB-Disease\ninpatients\tO\n(\tO\n59\tO\nwith\tO\nEPS\tB-Disease\nand\tO\n87\tO\nwithout\tO\nEPS\tB-Disease\naccording\tO\nto\tO\nthe\tO\nSimpson\tO\n-\tO\nAngus\tO\nScale\tO\n)\tO\ntreated\tO\nwith\tO\nchlorpromazine\tB-Chemical\nafter\tO\n8\tO\nweeks\tO\n.\tO\n\nThe\tO\nalleles\tO\nof\tO\nall\tO\nloci\tO\nwere\tO\ndetermined\tO\nby\tO\nPCR\tO\n(\tO\npolymerase\tO\nchain\tO\nreaction\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nPolymorphisms\tO\nTaqID\tO\n,\tO\nSer311Cys\tO\nand\tO\nrs6277\tO\nwere\tO\nnot\tO\npolymorphic\tO\nin\tO\nthe\tO\npopulation\tO\nrecruited\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\n.\tO\n\nNo\tO\nstatistical\tO\nsignificance\tO\nwas\tO\nfound\tO\nin\tO\nthe\tO\nallele\tO\ndistribution\tO\nof\tO\n-\tO\n141Cins\tO\n>\tO\ndel\tO\n,\tO\nTaqIB\tO\n,\tO\nrs6275\tO\nand\tO\nTaqIA\tO\nor\tO\nin\tO\nthe\tO\nestimated\tO\nhaplotypes\tO\n(\tO\nconstituted\tO\nby\tO\nTaqIB\tO\n,\tO\nrs6275\tO\nand\tO\nTaqIA\tO\n)\tO\nin\tO\nlinkage\tO\ndisequilibrium\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\nresults\tO\ndid\tO\nnot\tO\nlend\tO\nstrong\tO\nsupport\tO\nto\tO\nthe\tO\nview\tO\nthat\tO\nthe\tO\ngenetic\tO\nvariation\tO\nof\tO\nthe\tO\nDRD2\tO\ngene\tO\nplays\tO\na\tO\nmajor\tO\nrole\tO\nin\tO\nthe\tO\nindividually\tO\nvariable\tO\nadverse\tO\neffect\tO\ninduced\tO\nby\tO\nchlorpromazine\tB-Chemical\n,\tO\nat\tO\nleast\tO\nin\tO\nChinese\tO\npatients\tO\nwith\tO\nschizophrenia\tB-Disease\n.\tO\n\nOur\tO\nresults\tO\nconfirmed\tO\na\tO\nprevious\tO\nstudy\tO\non\tO\nthe\tO\nrelationship\tO\nbetween\tO\nDRD2\tO\nand\tO\nEPS\tB-Disease\nin\tO\nCaucasians\tO\n.\tO\n\nPhysical\tO\ntraining\tO\ndecreases\tO\nsusceptibility\tO\nto\tO\nsubsequent\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nRegular\tO\nmotor\tO\nactivity\tO\nhas\tO\nmany\tO\nbenefits\tO\nfor\tO\nmental\tO\nand\tO\nphysical\tO\ncondition\tO\nbut\tO\nits\tO\nimplications\tO\nfor\tO\nepilepsy\tB-Disease\nare\tO\nstill\tO\ncontroversial\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\nelucidate\tO\nthis\tO\nproblem\tO\n,\tO\nwe\tO\nhave\tO\nstudied\tO\nthe\tO\neffect\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nphysical\tO\nactivity\tO\non\tO\nsusceptibility\tO\nto\tO\nsubsequent\tO\nseizures\tB-Disease\n.\tO\n\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\nsubjected\tO\nto\tO\nrepeated\tO\ntraining\tO\nsessions\tO\nin\tO\na\tO\ntreadmill\tO\nand\tO\nswimming\tO\npool\tO\n.\tO\n\nThereafter\tO\n,\tO\nseizures\tB-Disease\nwere\tO\ninduced\tO\nby\tO\npilocarpine\tB-Chemical\ninjections\tO\nin\tO\ntrained\tO\nand\tO\nnon\tO\n-\tO\ntrained\tO\ncontrol\tO\ngroups\tO\n.\tO\n\nDuring\tO\nthe\tO\nacute\tO\nperiod\tO\nof\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n,\tO\nwe\tO\nmeasured\tO\n:\tO\n(\tO\n1\tO\n)\tO\nthe\tO\nlatency\tO\nof\tO\nthe\tO\nfirst\tO\nmotor\tO\nsign\tO\n,\tO\n(\tO\n2\tO\n)\tO\nthe\tO\nintensity\tO\nof\tO\nseizures\tB-Disease\n,\tO\n(\tO\n3\tO\n)\tO\nthe\tO\ntime\tO\nwhen\tO\nit\tO\noccurred\tO\nwithin\tO\nthe\tO\n6\tO\n-\tO\nh\tO\nobservation\tO\nperiod\tO\n,\tO\nand\tO\n(\tO\n4\tO\n)\tO\nthe\tO\ntime\tO\nwhen\tO\nthe\tO\nacute\tO\nperiod\tO\nended\tO\n.\tO\n\nAll\tO\nthese\tO\nbehavioral\tO\nparameters\tO\nshowed\tO\nstatistically\tO\nsignificant\tO\nchanges\tO\nsuggesting\tO\nthat\tO\nregular\tO\nphysical\tO\nexercises\tO\ndecrease\tO\nsusceptibility\tO\nto\tO\nsubsequently\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nameliorate\tO\nthe\tO\ncourse\tO\nof\tO\nexperimentally\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n.\tO\n\nTonic\tO\ndopaminergic\tO\nstimulation\tO\nimpairs\tB-Disease\nassociative\tI-Disease\nlearning\tI-Disease\nin\tO\nhealthy\tO\nsubjects\tO\n.\tO\n\nEndogenous\tO\ndopamine\tB-Chemical\nplays\tO\na\tO\ncentral\tO\nrole\tO\nin\tO\nsalience\tO\ncoding\tO\nduring\tO\nassociative\tO\nlearning\tO\n.\tO\n\nAdministration\tO\nof\tO\nthe\tO\ndopamine\tB-Chemical\nprecursor\tO\nlevodopa\tB-Chemical\nenhances\tO\nlearning\tO\nin\tO\nhealthy\tO\nsubjects\tO\nand\tO\nstroke\tB-Disease\npatients\tO\n.\tO\n\nBecause\tO\nlevodopa\tB-Chemical\nincreases\tO\nboth\tO\nphasic\tO\nand\tO\ntonic\tO\ndopaminergic\tO\nneurotransmission\tO\n,\tO\nthe\tO\ncritical\tO\nmechanism\tO\nmediating\tO\nthe\tO\nenhancement\tO\nof\tO\nlearning\tO\nis\tO\nunresolved\tO\n.\tO\n\nWe\tO\nhere\tO\nprobed\tO\nhow\tO\nselective\tO\ntonic\tO\ndopaminergic\tO\nstimulation\tO\naffects\tO\nassociative\tO\nlearning\tO\n.\tO\n\nForty\tO\nhealthy\tO\nsubjects\tO\nwere\tO\ntrained\tO\nin\tO\na\tO\nnovel\tO\nvocabulary\tO\nof\tO\n45\tO\nconcrete\tO\nnouns\tO\nover\tO\nthe\tO\ncourse\tO\nof\tO\n5\tO\nconsecutive\tO\ntraining\tO\ndays\tO\nin\tO\na\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ndesign\tO\n.\tO\n\nSubjects\tO\nreceived\tO\nthe\tO\ntonically\tO\nstimulating\tO\ndopamine\tB-Chemical\n-\tO\nreceptor\tO\nagonist\tO\npergolide\tB-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmg\tO\n)\tO\nvs\tO\nplacebo\tO\n120\tO\nmin\tO\nbefore\tO\ntraining\tO\non\tO\neach\tO\ntraining\tO\nday\tO\n.\tO\n\nThe\tO\ndopamine\tB-Chemical\nagonist\tO\nsignificantly\tO\nimpaired\tB-Disease\nnovel\tI-Disease\nword\tI-Disease\nlearning\tI-Disease\ncompared\tO\nto\tO\nplacebo\tO\n.\tO\n\nThis\tO\nlearning\tO\ndecrement\tO\npersisted\tO\nup\tO\nto\tO\nthe\tO\nlast\tO\nfollow\tO\n-\tO\nup\tO\n4\tO\nweeks\tO\npost\tO\n-\tO\ntraining\tO\n.\tO\n\nSubjects\tO\ntreated\tO\nwith\tO\npergolide\tB-Chemical\nalso\tO\nshowed\tO\nrestricted\tO\nemotional\tO\nresponses\tO\ncompared\tO\nto\tO\nthe\tO\nPLACEBO\tO\ngroup\tO\n.\tO\n\nThe\tO\nextent\tO\nof\tO\n'\tO\nflattened\tO\n'\tO\naffect\tO\nwith\tO\npergolide\tB-Chemical\nwas\tO\nrelated\tO\nto\tO\nthe\tO\ndegree\tO\nof\tO\nlearning\tO\ninhibition\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\ntonic\tO\noccupation\tO\nof\tO\ndopamine\tB-Chemical\nreceptors\tO\nimpairs\tO\nlearning\tO\nby\tO\ncompetition\tO\nwith\tO\nphasic\tO\ndopamine\tB-Chemical\nsignals\tO\n.\tO\n\nThus\tO\n,\tO\nphasic\tO\nsignaling\tO\nseems\tO\nto\tO\nbe\tO\nthe\tO\ncritical\tO\nmechanism\tO\nby\tO\nwhich\tO\ndopamine\tB-Chemical\nenhances\tO\nassociative\tO\nlearning\tO\nin\tO\nhealthy\tO\nsubjects\tO\nand\tO\nstroke\tB-Disease\npatients\tO\n.\tO\n\nMinocycline\tB-Chemical\n-\tO\ninduced\tO\nvasculitis\tB-Disease\nfulfilling\tO\nthe\tO\ncriteria\tO\nof\tO\npolyarteritis\tB-Disease\nnodosa\tI-Disease\n.\tO\n\nA\tO\n47\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\nhad\tO\nbeen\tO\ntaking\tO\nminocycline\tB-Chemical\nfor\tO\npalmoplantar\tB-Disease\npustulosis\tI-Disease\ndeveloped\tO\nfever\tB-Disease\n,\tO\nmyalgias\tB-Disease\n,\tO\npolyneuropathy\tB-Disease\n,\tO\nand\tO\ntesticular\tB-Disease\npain\tI-Disease\n,\tO\nwith\tO\nelevated\tO\nC\tO\n-\tO\nreactive\tO\nprotein\tO\n(\tO\nCRP\tO\n)\tO\n.\tO\n\nNeither\tO\nmyeloperoxidase\tO\n-\tO\nnor\tO\nproteinase\tO\n-\tO\n3\tO\n-\tO\nantineutrophil\tO\ncytoplasmic\tO\nantibody\tO\nwas\tO\npositive\tO\n.\tO\n\nThese\tO\nmanifestations\tO\nmet\tO\nthe\tO\nAmerican\tO\nCollege\tO\nof\tO\nRheumatology\tO\n1990\tO\ncriteria\tO\nfor\tO\nthe\tO\nclassification\tO\nof\tO\npolyarteritis\tB-Disease\nnodosa\tI-Disease\n.\tO\n\nStopping\tO\nminocycline\tB-Chemical\nled\tO\nto\tO\namelioration\tO\nof\tO\nsymptoms\tO\nand\tO\nnormalization\tO\nof\tO\nCRP\tO\nlevel\tO\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nsecond\tO\ncase\tO\nof\tO\nminocycline\tB-Chemical\n-\tO\ninduced\tO\nvasculitis\tB-Disease\nsatisfying\tO\nthe\tO\ncriteria\tO\n.\tO\n\nDifferential\tO\ndiagnosis\tO\nfor\tO\ndrug\tO\n-\tO\ninduced\tO\ndisease\tO\nis\tO\ninvaluable\tO\neven\tO\nfor\tO\npatients\tO\nwith\tO\nclassical\tO\npolyarteritis\tB-Disease\nnodosa\tI-Disease\n.\tO\n\nIntramuscular\tO\nhepatitis\tB-Disease\nB\tI-Disease\nimmune\tO\nglobulin\tO\ncombined\tO\nwith\tO\nlamivudine\tB-Chemical\nin\tO\nprevention\tO\nof\tO\nhepatitis\tB-Disease\nB\tI-Disease\nrecurrence\tO\nafter\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCombined\tO\nhepatitis\tB-Disease\nB\tI-Disease\nimmune\tO\nglobulin\tO\n(\tO\nHBIg\tO\n)\tO\nand\tO\nlamivudine\tB-Chemical\nin\tO\nprophylaxis\tO\nof\tO\nthe\tO\nrecurrence\tO\nof\tO\nhepatitis\tB-Disease\nB\tI-Disease\nafter\tO\nliver\tO\ntransplantation\tO\nhas\tO\nsignificantly\tO\nimproved\tO\nthe\tO\nsurvival\tO\nof\tO\nHBsAg\tB-Chemical\npositive\tO\npatients\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\nevaluate\tO\nthe\tO\noutcomes\tO\nof\tO\nliver\tO\ntransplantation\tO\nfor\tO\npatients\tO\nwith\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\n(\tO\nHBV\tO\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nretrospective\tO\nchart\tO\nanalysis\tO\nand\tO\na\tO\nreview\tO\nof\tO\nthe\tO\norgan\tO\ntransplant\tO\ndatabase\tO\nidentified\tO\n51\tO\npatients\tO\n(\tO\n43\tO\nmen\tO\nand\tO\n8\tO\nwomen\tO\n)\tO\ntransplanted\tO\nfor\tO\nbenign\tO\nHBV\tO\n-\tO\nrelated\tO\ncirrhotic\tB-Disease\ndiseases\tI-Disease\nbetween\tO\nJune\tO\n2002\tO\nand\tO\nDecember\tO\n2004\tO\nwho\tO\nhad\tO\nsurvived\tO\nmore\tO\nthan\tO\n3\tO\nmonths\tO\n.\tO\n\nHBIg\tO\nwas\tO\nadministered\tO\nintravenously\tO\nduring\tO\nthe\tO\nfirst\tO\nweek\tO\nand\tO\nintramuscularly\tO\nthereafter\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAt\tO\na\tO\nmedian\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n14\tO\n.\tO\n1\tO\nmonths\tO\n,\tO\nthe\tO\noverall\tO\nrecurrence\tO\nrate\tO\nin\tO\nthe\tO\n51\tO\npatients\tO\nwas\tO\n3\tO\n.\tO\n9\tO\n%\tO\n(\tO\n2\tO\n/\tO\n51\tO\n)\tO\n.\tO\n\nThe\tO\noverall\tO\npatient\tO\nsurvival\tO\nwas\tO\n88\tO\n.\tO\n3\tO\n%\tO\n,\tO\nand\tO\n82\tO\n.\tO\n4\tO\n%\tO\nafter\tO\n1\tO\nand\tO\n2\tO\nyears\tO\n,\tO\nrespectively\tO\n.\tO\n\nA\tO\ndaily\tO\noral\tO\ndose\tO\nof\tO\n100\tO\nmg\tO\nlamivudine\tB-Chemical\nfor\tO\n2\tO\nweeks\tO\nbefore\tO\ntransplantation\tO\nfor\tO\n10\tO\npatients\tO\nenabled\tO\n57\tO\n.\tO\n1\tO\n%\tO\n(\tO\n4\tO\n/\tO\n7\tO\n)\tO\nand\tO\n62\tO\n.\tO\n5\tO\n%\tO\n(\tO\n5\tO\n/\tO\n8\tO\n)\tO\nof\tO\nHBV\tO\n-\tO\nDNA\tO\nand\tO\nHBeAg\tB-Chemical\npositive\tO\npatients\tO\nrespectively\tO\nto\tO\nconvert\tO\nto\tO\nbe\tO\nnegative\tO\n.\tO\n\nIntramuscular\tO\nHBIg\tO\nwas\tO\nwell\tO\ntolerated\tO\nin\tO\nall\tO\npatients\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nLamivudine\tB-Chemical\ncombined\tO\nwith\tO\nintramuscular\tO\nHBIg\tO\ncan\tO\neffectively\tO\nprevent\tO\nallograft\tO\nfrom\tO\nthe\tO\nrecurrence\tO\nof\tO\nHBV\tO\nafter\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nAnticonvulsant\tO\neffect\tO\nof\tO\neslicarbazepine\tB-Chemical\nacetate\tI-Chemical\n(\tO\nBIA\tB-Chemical\n2\tI-Chemical\n-\tI-Chemical\n093\tI-Chemical\n)\tO\non\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\nmicroperfusion\tO\nof\tO\npicrotoxin\tB-Chemical\nin\tO\nthe\tO\nhippocampus\tO\nof\tO\nfreely\tO\nmoving\tO\nrats\tO\n.\tO\n\nEslicarbazepine\tB-Chemical\nacetate\tI-Chemical\n(\tO\nBIA\tB-Chemical\n2\tI-Chemical\n-\tI-Chemical\n093\tI-Chemical\n,\tO\nS\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n-\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n10\tI-Chemical\n-\tI-Chemical\nacetoxy\tI-Chemical\n-\tI-Chemical\n10\tI-Chemical\n,\tI-Chemical\n11\tI-Chemical\n-\tI-Chemical\ndihydro\tI-Chemical\n-\tI-Chemical\n5H\tI-Chemical\n-\tI-Chemical\ndibenzo\tI-Chemical\n/\tI-Chemical\nb\tI-Chemical\n,\tI-Chemical\nf\tI-Chemical\n/\tI-Chemical\nazepine\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\ncarboxamide\tI-Chemical\n)\tO\nis\tO\na\tO\nnovel\tO\nantiepileptic\tO\ndrug\tO\n,\tO\nnow\tO\nin\tO\nPhase\tO\nIII\tO\nclinical\tO\ntrials\tO\n,\tO\ndesigned\tO\nwith\tO\nthe\tO\naim\tO\nof\tO\nimproving\tO\nefficacy\tO\nand\tO\nsafety\tO\nin\tO\ncomparison\tO\nwith\tO\nthe\tO\nstructurally\tO\nrelated\tO\ndrugs\tO\ncarbamazepine\tB-Chemical\n(\tO\nCBZ\tB-Chemical\n)\tO\nand\tO\noxcarbazepine\tB-Chemical\n(\tO\nOXC\tB-Chemical\n)\tO\n.\tO\n\nWe\tO\nhave\tO\nstudied\tO\nthe\tO\neffects\tO\nof\tO\noral\tO\ntreatment\tO\nwith\tO\neslicarbazepine\tB-Chemical\nacetate\tI-Chemical\non\tO\na\tO\nwhole\tO\n-\tO\nanimal\tO\nmodel\tO\nin\tO\nwhich\tO\npartial\tO\nseizures\tB-Disease\ncan\tO\nbe\tO\nelicited\tO\nrepeatedly\tO\non\tO\ndifferent\tO\ndays\tO\nwithout\tO\nchanges\tO\nin\tO\nthreshold\tO\nor\tO\nseizure\tB-Disease\npatterns\tO\n.\tO\n\nIn\tO\nthe\tO\nanimals\tO\ntreated\tO\nwith\tO\nthreshold\tO\ndoses\tO\nof\tO\npicrotoxin\tB-Chemical\n,\tO\nthe\tO\naverage\tO\nnumber\tO\nof\tO\nseizures\tB-Disease\nwas\tO\n2\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n2\tO\n,\tO\nand\tO\naverage\tO\nseizure\tB-Disease\nduration\tO\nwas\tO\n39\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n8\tO\n.\tO\n4s\tO\n.\tO\n\nPre\tO\n-\tO\ntreatment\tO\nwith\tO\na\tO\ndose\tO\nof\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n2h\tO\nbefore\tO\npicrotoxin\tB-Chemical\nmicroperfusion\tO\nprevented\tO\nseizures\tB-Disease\nin\tO\nthe\tO\n75\tO\n%\tO\nof\tO\nthe\tO\nrats\tO\n.\tO\n\nLower\tO\ndoses\tO\n(\tO\n3\tO\nand\tO\n10mg\tO\n/\tO\nkg\tO\n)\tO\ndid\tO\nnot\tO\nsuppress\tO\nseizures\tB-Disease\n,\tO\nhowever\tO\n,\tO\nafter\tO\nadministration\tO\nof\tO\n10mg\tO\n/\tO\nkg\tO\n,\tO\nsignificant\tO\nreductions\tO\nin\tO\nseizures\tB-Disease\nduration\tO\n(\tO\n24\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n8s\tO\n)\tO\nand\tO\nseizure\tB-Disease\nnumber\tO\n(\tO\n1\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n34\tO\n)\tO\nwere\tO\nfound\tO\n.\tO\n\nNo\tO\nadverse\tO\neffects\tO\nof\tO\neslicarbazepine\tB-Chemical\nacetate\tI-Chemical\nwere\tO\nobserved\tO\nin\tO\nthe\tO\nbehavioral\tO\n/\tO\nEEG\tO\npatterns\tO\nstudied\tO\n,\tO\nincluding\tO\nsleep\tO\n/\tO\nwakefulness\tO\ncycle\tO\n,\tO\nat\tO\nthe\tO\ndoses\tO\nstudied\tO\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nassociated\tO\nwith\tO\nprolonged\tO\nintake\tO\nof\tO\nslimming\tO\npills\tO\ncontaining\tO\nanthraquinones\tB-Chemical\n.\tO\n\nChinese\tB-Chemical\nherbal\tI-Chemical\nmedicine\tO\npreparations\tO\nare\tO\nwidely\tO\navailable\tO\nand\tO\noften\tO\nregarded\tO\nby\tO\nthe\tO\npublic\tO\nas\tO\nnatural\tO\nand\tO\nsafe\tO\nremedies\tO\nfor\tO\na\tO\nvariety\tO\nof\tO\nmedical\tO\nconditions\tO\n.\tO\n\nNephropathy\tB-Disease\ncaused\tO\nby\tO\nChinese\tB-Chemical\nherbs\tI-Chemical\nhas\tO\npreviously\tO\nbeen\tO\nreported\tO\n,\tO\nusually\tO\ninvolving\tO\nthe\tO\nuse\tO\nof\tO\naristolochic\tB-Chemical\nacids\tI-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\n23\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwho\tO\ndeveloped\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nfollowing\tO\nprolonged\tO\nuse\tO\nof\tO\na\tO\nproprietary\tO\nChinese\tB-Chemical\nherbal\tI-Chemical\nslimming\tO\npill\tO\nthat\tO\ncontained\tO\nanthraquinone\tB-Chemical\nderivatives\tO\n,\tO\nextracted\tO\nfrom\tO\nRhizoma\tO\nRhei\tO\n(\tO\nrhubarb\tO\n)\tO\n.\tO\n\nThe\tO\nrenal\tB-Disease\ninjury\tI-Disease\nwas\tO\nprobably\tO\naggravated\tO\nby\tO\nthe\tO\nconcomitant\tO\nintake\tO\nof\tO\na\tO\nnon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrug\tO\n,\tO\ndiclofenac\tB-Chemical\n.\tO\n\nRenal\tO\npathology\tO\nwas\tO\nthat\tO\nof\tO\nhypocellular\tO\ninterstitial\tO\nfibrosis\tB-Disease\n.\tO\n\nSpontaneous\tO\nrenal\tO\nrecovery\tO\noccurred\tO\nupon\tO\ncessation\tO\nof\tO\nthe\tO\nslimming\tO\npills\tO\n,\tO\nbut\tO\nmild\tO\ninterstitial\tO\nfibrosis\tB-Disease\nand\tO\ntubular\tO\natrophy\tB-Disease\nwas\tO\nstill\tO\nevident\tO\nhistologically\tO\n4\tO\nmonths\tO\nlater\tO\n.\tO\n\nAlthough\tO\na\tO\ncausal\tO\nrelationship\tO\nbetween\tO\nthe\tO\nuse\tO\nof\tO\nan\tO\nanthraquinone\tB-Chemical\n-\tO\ncontaining\tO\nherbal\tO\nagent\tO\nand\tO\nrenal\tB-Disease\ninjury\tI-Disease\nremains\tO\nto\tO\nbe\tO\nproven\tO\n,\tO\nphytotherapy\tO\n-\tO\nassociated\tO\ninterstitial\tO\nnephropathy\tB-Disease\nshould\tO\nbe\tO\nconsidered\tO\nin\tO\npatients\tO\nwho\tO\npresent\tO\nwith\tO\nunexplained\tO\nrenal\tB-Disease\nfailure\tI-Disease\n.\tO\n\nChloroacetaldehyde\tB-Chemical\nas\tO\na\tO\nsulfhydryl\tB-Chemical\nreagent\tO\n:\tO\nthe\tO\nrole\tO\nof\tO\ncritical\tO\nthiol\tB-Chemical\ngroups\tO\nin\tO\nifosfamide\tB-Chemical\nnephropathy\tB-Disease\n.\tO\n\nChloroacetaldehyde\tB-Chemical\n(\tO\nCAA\tB-Chemical\n)\tO\nis\tO\na\tO\nmetabolite\tO\nof\tO\nthe\tO\nalkylating\tO\nagent\tO\nifosfamide\tB-Chemical\n(\tO\nIFO\tB-Chemical\n)\tO\nand\tO\nputatively\tO\nresponsible\tO\nfor\tO\nrenal\tB-Disease\ndamage\tI-Disease\nfollowing\tO\nanti\tO\n-\tO\ntumor\tB-Disease\ntherapy\tO\nwith\tO\nIFO\tB-Chemical\n.\tO\n\nDepletion\tO\nof\tO\nsulfhydryl\tB-Chemical\n(\tO\nSH\tB-Chemical\n)\tO\ngroups\tO\nhas\tO\nbeen\tO\nreported\tO\nfrom\tO\ncell\tO\nculture\tO\n,\tO\nanimal\tO\nand\tO\nclinical\tO\nstudies\tO\n.\tO\n\nIn\tO\nthis\tO\nwork\tO\nthe\tO\neffect\tO\nof\tO\nCAA\tB-Chemical\non\tO\nhuman\tO\nproximal\tO\ntubule\tO\ncells\tO\nin\tO\nprimary\tO\nculture\tO\n(\tO\nhRPTEC\tO\n)\tO\nwas\tO\ninvestigated\tO\n.\tO\n\nToxicity\tB-Disease\nof\tO\nCAA\tB-Chemical\nwas\tO\ndetermined\tO\nby\tO\nprotein\tO\ncontent\tO\n,\tO\ncell\tO\nnumber\tO\n,\tO\nLDH\tO\nrelease\tO\n,\tO\ntrypan\tB-Chemical\nblue\tI-Chemical\nexclusion\tO\nassay\tO\nand\tO\ncaspase\tO\n-\tO\n3\tO\nactivity\tO\n.\tO\n\nFree\tO\nthiols\tB-Chemical\nwere\tO\nmeasured\tO\nby\tO\nthe\tO\nmethod\tO\nof\tO\nEllman\tO\n.\tO\n\nCAA\tB-Chemical\nreduced\tO\nhRPTEC\tO\ncell\tO\nnumber\tO\nand\tO\nprotein\tO\n,\tO\ninduced\tO\na\tO\nloss\tO\nin\tO\nfree\tO\nintracellular\tO\nthiols\tB-Chemical\nand\tO\nan\tO\nincrease\tO\nin\tO\nnecrosis\tB-Disease\nmarkers\tO\n.\tO\n\nCAA\tB-Chemical\nbut\tO\nnot\tO\nacrolein\tB-Chemical\ninhibited\tO\nthe\tO\ncysteine\tB-Chemical\nproteases\tO\ncaspase\tO\n-\tO\n3\tO\n,\tO\ncaspase\tO\n-\tO\n8\tO\nand\tO\ncathepsin\tO\nB\tO\n.\tO\n\nCaspase\tO\nactivation\tO\nby\tO\ncisplatin\tB-Chemical\nwas\tO\ninhibited\tO\nby\tO\nCAA\tB-Chemical\n.\tO\n\nIn\tO\ncells\tO\nstained\tO\nwith\tO\nfluorescent\tO\ndyes\tO\ntargeting\tO\nlysosomes\tO\n,\tO\nCAA\tB-Chemical\ninduced\tO\nan\tO\nincrease\tO\nin\tO\nlysosomal\tO\nsize\tO\nand\tO\nlysosomal\tO\nleakage\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nCAA\tB-Chemical\non\tO\ncysteine\tB-Chemical\nprotease\tO\nactivities\tO\nand\tO\nthiols\tB-Chemical\ncould\tO\nbe\tO\nreproduced\tO\nin\tO\ncell\tO\nlysate\tO\n.\tO\n\nAcidification\tO\n,\tO\nwhich\tO\nslowed\tO\nthe\tO\nreaction\tO\nof\tO\nCAA\tB-Chemical\nwith\tO\nthiol\tB-Chemical\ndonors\tO\n,\tO\ncould\tO\nalso\tO\nattenuate\tO\neffects\tO\nof\tO\nCAA\tB-Chemical\non\tO\nnecrosis\tB-Disease\nmarkers\tO\n,\tO\nthiol\tB-Chemical\ndepletion\tO\nand\tO\ncysteine\tB-Chemical\nprotease\tO\ninhibition\tO\nin\tO\nliving\tO\ncells\tO\n.\tO\n\nThus\tO\n,\tO\nCAA\tB-Chemical\ndirectly\tO\nreacts\tO\nwith\tO\ncellular\tO\nprotein\tO\nand\tO\nnon\tO\n-\tO\nprotein\tO\nthiols\tB-Chemical\n,\tO\nmediating\tO\nits\tO\ntoxicity\tB-Disease\non\tO\nhRPTEC\tO\n.\tO\n\nThis\tO\neffect\tO\ncan\tO\nbe\tO\nreduced\tO\nby\tO\nacidification\tO\n.\tO\n\nTherefore\tO\n,\tO\nurinary\tO\nacidification\tO\ncould\tO\nbe\tO\nan\tO\noption\tO\nto\tO\nprevent\tO\nIFO\tB-Chemical\nnephropathy\tB-Disease\nin\tO\npatients\tO\n.\tO\n\nStereological\tO\nmethods\tO\nreveal\tO\nthe\tO\nrobust\tO\nsize\tO\nand\tO\nstability\tO\nof\tO\nectopic\tO\nhilar\tO\ngranule\tO\ncells\tO\nafter\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nin\tO\nthe\tO\nadult\tO\nrat\tO\n.\tO\n\nFollowing\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nin\tO\nthe\tO\nrat\tO\n,\tO\ndentate\tO\ngranule\tO\ncell\tO\nneurogenesis\tO\nincreases\tO\ngreatly\tO\n,\tO\nand\tO\nmany\tO\nof\tO\nthe\tO\nnew\tO\nneurons\tO\nappear\tO\nto\tO\ndevelop\tO\nectopically\tO\n,\tO\nin\tO\nthe\tO\nhilar\tO\nregion\tO\nof\tO\nthe\tO\nhippocampal\tO\nformation\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nsuggested\tO\nthat\tO\nthe\tO\nectopic\tO\nhilar\tO\ngranule\tO\ncells\tO\ncould\tO\ncontribute\tO\nto\tO\nthe\tO\nspontaneous\tO\nseizures\tB-Disease\nthat\tO\nultimately\tO\ndevelop\tO\nafter\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\npopulation\tO\nhas\tO\nnever\tO\nbeen\tO\nquantified\tO\n,\tO\nso\tO\nit\tO\nis\tO\nunclear\tO\nwhether\tO\nit\tO\nis\tO\nsubstantial\tO\nenough\tO\nto\tO\nhave\tO\na\tO\nstrong\tO\ninfluence\tO\non\tO\nepileptogenesis\tO\n.\tO\n\nTo\tO\nquantify\tO\nthis\tO\npopulation\tO\n,\tO\nthe\tO\ntotal\tO\nnumber\tO\nof\tO\nectopic\tO\nhilar\tO\ngranule\tO\ncells\tO\nwas\tO\nestimated\tO\nusing\tO\nunbiased\tO\nstereology\tO\nat\tO\ndifferent\tO\ntimes\tO\nafter\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\nhilar\tO\nneurons\tO\nimmunoreactive\tO\nfor\tO\nProx\tO\n-\tO\n1\tO\n,\tO\na\tO\ngranule\tO\n-\tO\ncell\tO\n-\tO\nspecific\tO\nmarker\tO\n,\tO\nwas\tO\nestimated\tO\nusing\tO\nthe\tO\noptical\tO\nfractionator\tO\nmethod\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nthe\tO\nsize\tO\nof\tO\nthe\tO\nhilar\tO\nectopic\tO\ngranule\tO\ncell\tO\npopulation\tO\nafter\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nis\tO\nsubstantial\tO\n,\tO\nand\tO\nstable\tO\nover\tO\ntime\tO\n.\tO\n\nInterestingly\tO\n,\tO\nthe\tO\nsize\tO\nof\tO\nthe\tO\npopulation\tO\nappears\tO\nto\tO\nbe\tO\ncorrelated\tO\nwith\tO\nthe\tO\nfrequency\tO\nof\tO\nbehavioral\tO\nseizures\tB-Disease\n,\tO\nbecause\tO\nanimals\tO\nwith\tO\nmore\tO\nectopic\tO\ngranule\tO\ncells\tO\nin\tO\nthe\tO\nhilus\tO\nhave\tO\nmore\tO\nfrequent\tO\nbehavioral\tO\nseizures\tB-Disease\n.\tO\n\nThe\tO\nhilar\tO\nectopic\tO\ngranule\tO\ncell\tO\npopulation\tO\ndoes\tO\nnot\tO\nappear\tO\nto\tO\nvary\tO\nsystematically\tO\nacross\tO\nthe\tO\nseptotemporal\tO\naxis\tO\n,\tO\nalthough\tO\nit\tO\nis\tO\nassociated\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nvolume\tO\nof\tO\nthe\tO\nhilus\tO\n.\tO\n\nThe\tO\nresults\tO\nprovide\tO\nnew\tO\ninsight\tO\ninto\tO\nthe\tO\npotential\tO\nrole\tO\nof\tO\nectopic\tO\nhilar\tO\ngranule\tO\ncells\tO\nin\tO\nthe\tO\npilocarpine\tB-Chemical\nmodel\tO\nof\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\n.\tO\n\nA\tO\nprospective\tO\n,\tO\nopen\tO\n-\tO\nlabel\tO\ntrial\tO\nof\tO\ngalantamine\tB-Chemical\nin\tO\nautistic\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nPost\tO\n-\tO\nmortem\tO\nstudies\tO\nhave\tO\nreported\tO\nabnormalities\tO\nof\tO\nthe\tO\ncholinergic\tO\nsystem\tO\nin\tO\nautism\tB-Disease\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nassess\tO\nthe\tO\nuse\tO\nof\tO\ngalantamine\tB-Chemical\n,\tO\nan\tO\nacetylcholinesterase\tO\ninhibitor\tO\nand\tO\nnicotinic\tO\nreceptor\tO\nmodulator\tO\n,\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\ninterfering\tO\nbehaviors\tO\nin\tO\nchildren\tO\nwith\tO\nautism\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThirteen\tO\nmedication\tO\n-\tO\nfree\tO\nchildren\tO\nwith\tO\nautism\tB-Disease\n(\tO\nmean\tO\nage\tO\n,\tO\n8\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n5\tO\nyears\tO\n)\tO\nparticipated\tO\nin\tO\na\tO\n12\tO\n-\tO\nweek\tO\n,\tO\nopen\tO\n-\tO\nlabel\tO\ntrial\tO\nof\tO\ngalantamine\tB-Chemical\n.\tO\n\nPatients\tO\nwere\tO\nrated\tO\nmonthly\tO\nby\tO\nparents\tO\non\tO\nthe\tO\nAberrant\tO\nBehavior\tO\nChecklist\tO\n(\tO\nABC\tO\n)\tO\nand\tO\nthe\tO\nConners\tO\n'\tO\nParent\tO\nRating\tO\nScale\tO\n-\tO\nRevised\tO\n,\tO\nand\tO\nby\tO\na\tO\nphysician\tO\nusing\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nPsychiatric\tO\nRating\tO\nScale\tO\nand\tO\nthe\tO\nClinical\tO\nGlobal\tO\nImpressions\tO\nscale\tO\n.\tO\n\nRESULTS\tO\n:\tO\nPatients\tO\nshowed\tO\na\tO\nsignificant\tO\nreduction\tO\nin\tO\nparent\tO\n-\tO\nrated\tO\nirritability\tB-Disease\nand\tO\nsocial\tO\nwithdrawal\tO\non\tO\nthe\tO\nABC\tO\nas\tO\nwell\tO\nas\tO\nsignificant\tO\nimprovements\tO\nin\tO\nemotional\tO\nlability\tO\nand\tO\ninattention\tO\non\tO\nthe\tO\nConners\tO\n'\tO\nParent\tO\nRating\tO\nScale\tO\n-\tO\n-\tO\nRevised\tO\n.\tO\n\nSimilarly\tO\n,\tO\nclinician\tO\nratings\tO\nshowed\tO\nreductions\tO\nin\tO\nthe\tO\nanger\tO\nsubscale\tO\nof\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nPsychiatric\tO\nRating\tO\nScale\tO\n.\tO\n\nEight\tO\nof\tO\n13\tO\nparticipants\tO\nwere\tO\nrated\tO\nas\tO\nresponders\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\ntheir\tO\nimprovement\tO\nscores\tO\non\tO\nthe\tO\nClinical\tO\nGlobal\tO\nImpressions\tO\nscale\tO\n.\tO\n\nOverall\tO\n,\tO\ngalantamine\tB-Chemical\nwas\tO\nwell\tO\n-\tO\ntolerated\tO\n,\tO\nwith\tO\nno\tO\nsignificant\tO\nadverse\tO\neffects\tO\napart\tO\nfrom\tO\nheadaches\tB-Disease\nin\tO\none\tO\npatient\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\nthis\tO\nopen\tO\ntrial\tO\n,\tO\ngalantamine\tB-Chemical\nwas\tO\nwell\tO\n-\tO\ntolerated\tO\nand\tO\nappeared\tO\nto\tO\nbe\tO\nbeneficial\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\ninterfering\tO\nbehaviors\tO\nin\tO\nchildren\tO\nwith\tO\nautism\tB-Disease\n,\tO\nparticularly\tO\naggression\tB-Disease\n,\tO\nbehavioral\tB-Disease\ndyscontrol\tI-Disease\n,\tO\nand\tO\ninattention\tB-Disease\n.\tO\n\nFurther\tO\ncontrolled\tO\ntrials\tO\nare\tO\nwarranted\tO\n.\tO\n\nRandomized\tO\ncomparison\tO\nof\tO\nolanzapine\tB-Chemical\nversus\tO\nrisperidone\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nfirst\tO\n-\tO\nepisode\tO\nschizophrenia\tB-Disease\n:\tO\n4\tO\n-\tO\nmonth\tO\noutcomes\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\nauthors\tO\ncompared\tO\n4\tO\n-\tO\nmonth\tO\ntreatment\tO\noutcomes\tO\nfor\tO\nolanzapine\tB-Chemical\nversus\tO\nrisperidone\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nfirst\tO\n-\tO\nepisode\tO\nschizophrenia\tB-Disease\nspectrum\tO\ndisorders\tO\n.\tO\n\nMETHOD\tO\n:\tO\nOne\tO\nhundred\tO\ntwelve\tO\nsubjects\tO\n(\tO\n70\tO\n%\tO\nmale\tO\n;\tO\nmean\tO\nage\tO\n=\tO\n23\tO\n.\tO\n3\tO\nyears\tO\n[\tO\nSD\tO\n=\tO\n5\tO\n.\tO\n1\tO\n]\tO\n)\tO\nwith\tO\nfirst\tO\n-\tO\nepisode\tO\nschizophrenia\tB-Disease\n(\tO\n75\tO\n%\tO\n)\tO\n,\tO\nschizophreniform\tB-Disease\ndisorder\tI-Disease\n(\tO\n17\tO\n%\tO\n)\tO\n,\tO\nor\tO\nschizoaffective\tB-Disease\ndisorder\tI-Disease\n(\tO\n8\tO\n%\tO\n)\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\ntreatment\tO\nwith\tO\nolanzapine\tB-Chemical\n(\tO\n2\tO\n.\tO\n5\tO\n-\tO\n20\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nor\tO\nrisperidone\tB-Chemical\n(\tO\n1\tO\n-\tO\n6\tO\nmg\tO\n/\tO\nday\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nResponse\tO\nrates\tO\ndid\tO\nnot\tO\nsignificantly\tO\ndiffer\tO\nbetween\tO\nolanzapine\tB-Chemical\n(\tO\n43\tO\n.\tO\n7\tO\n%\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n28\tO\n.\tO\n8\tO\n%\tO\n-\tO\n58\tO\n.\tO\n6\tO\n%\tO\n)\tO\nand\tO\nrisperidone\tB-Chemical\n(\tO\n54\tO\n.\tO\n3\tO\n%\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n39\tO\n.\tO\n9\tO\n%\tO\n-\tO\n68\tO\n.\tO\n7\tO\n%\tO\n)\tO\n.\tO\n\nAmong\tO\nthose\tO\nresponding\tO\nto\tO\ntreatment\tO\n,\tO\nmore\tO\nsubjects\tO\nin\tO\nthe\tO\nolanzapine\tB-Chemical\ngroup\tO\n(\tO\n40\tO\n.\tO\n9\tO\n%\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n16\tO\n.\tO\n8\tO\n%\tO\n-\tO\n65\tO\n.\tO\n0\tO\n%\tO\n)\tO\nthan\tO\nin\tO\nthe\tO\nrisperidone\tB-Chemical\ngroup\tO\n(\tO\n18\tO\n.\tO\n9\tO\n%\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n0\tO\n%\tO\n-\tO\n39\tO\n.\tO\n2\tO\n%\tO\n)\tO\nhad\tO\nsubsequent\tO\nratings\tO\nnot\tO\nmeeting\tO\nresponse\tO\ncriteria\tO\n.\tO\n\nNegative\tO\nsymptom\tO\noutcomes\tO\nand\tO\nmeasures\tO\nof\tO\nparkinsonism\tB-Disease\nand\tO\nakathisia\tB-Disease\ndid\tO\nnot\tO\ndiffer\tO\nbetween\tO\nmedications\tO\n.\tO\n\nExtrapyramidal\tB-Disease\nsymptom\tI-Disease\nseverity\tO\nscores\tO\nwere\tO\n1\tO\n.\tO\n4\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n1\tO\n.\tO\n2\tO\n-\tO\n1\tO\n.\tO\n6\tO\n)\tO\nwith\tO\nrisperidone\tB-Chemical\nand\tO\n1\tO\n.\tO\n2\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n1\tO\n.\tO\n0\tO\n-\tO\n1\tO\n.\tO\n4\tO\n)\tO\nwith\tO\nolanzapine\tB-Chemical\n.\tO\n\nSignificantly\tO\nmore\tO\nweight\tB-Disease\ngain\tI-Disease\noccurred\tO\nwith\tO\nolanzapine\tB-Chemical\nthan\tO\nwith\tO\nrisperidone\tB-Chemical\n:\tO\nthe\tO\nincrease\tO\nin\tO\nweight\tO\nat\tO\n4\tO\nmonths\tO\nrelative\tO\nto\tO\nbaseline\tO\nweight\tO\nwas\tO\n17\tO\n.\tO\n3\tO\n%\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n14\tO\n.\tO\n2\tO\n%\tO\n-\tO\n20\tO\n.\tO\n5\tO\n%\tO\n)\tO\nwith\tO\nolanzapine\tB-Chemical\nand\tO\n11\tO\n.\tO\n3\tO\n%\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n8\tO\n.\tO\n4\tO\n%\tO\n-\tO\n14\tO\n.\tO\n3\tO\n%\tO\n)\tO\nwith\tO\nrisperidone\tB-Chemical\n.\tO\n\nBody\tO\nmass\tO\nindex\tO\nat\tO\nbaseline\tO\nand\tO\nat\tO\n4\tO\nmonths\tO\nwas\tO\n24\tO\n.\tO\n3\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n22\tO\n.\tO\n8\tO\n-\tO\n25\tO\n.\tO\n7\tO\n)\tO\nversus\tO\n28\tO\n.\tO\n2\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n26\tO\n.\tO\n7\tO\n-\tO\n29\tO\n.\tO\n7\tO\n)\tO\nwith\tO\nolanzapine\tB-Chemical\nand\tO\n23\tO\n.\tO\n9\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n22\tO\n.\tO\n5\tO\n-\tO\n25\tO\n.\tO\n3\tO\n)\tO\nversus\tO\n26\tO\n.\tO\n7\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n25\tO\n.\tO\n2\tO\n-\tO\n28\tO\n.\tO\n2\tO\n)\tO\nwith\tO\nrisperidone\tB-Chemical\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nClinical\tO\noutcomes\tO\nwith\tO\nrisperidone\tB-Chemical\nwere\tO\nequal\tO\nto\tO\nthose\tO\nwith\tO\nolanzapine\tB-Chemical\n,\tO\nand\tO\nresponse\tO\nmay\tO\nbe\tO\nmore\tO\nstable\tO\n.\tO\n\nOlanzapine\tB-Chemical\nmay\tO\nhave\tO\nan\tO\nadvantage\tO\nfor\tO\nmotor\tO\nside\tO\neffects\tO\n.\tO\n\nBoth\tO\nmedications\tO\ncaused\tO\nsubstantial\tO\nrapid\tO\nweight\tB-Disease\ngain\tI-Disease\n,\tO\nbut\tO\nweight\tB-Disease\ngain\tI-Disease\nwas\tO\ngreater\tO\nwith\tO\nolanzapine\tB-Chemical\n.\tO\n\nEarly\tO\nparacentral\tO\nvisual\tB-Disease\nfield\tI-Disease\nloss\tI-Disease\nin\tO\npatients\tO\ntaking\tO\nhydroxychloroquine\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreview\tO\nthe\tO\nnatural\tO\nhistory\tO\nand\tO\nocular\tO\nand\tO\nsystemic\tO\nadverse\tO\neffects\tO\nof\tO\npatients\tO\ntaking\tO\nhydroxychloroquine\tB-Chemical\nsulfate\tI-Chemical\nwho\tO\nattended\tO\nan\tO\nophthalmic\tO\nscreening\tO\nprogram\tO\n.\tO\n\nDESIGN\tO\n:\tO\nRetrospective\tO\nstudy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nRecords\tO\nof\tO\n262\tO\npatients\tO\nwho\tO\nwere\tO\ntaking\tO\nhydroxychloroquine\tB-Chemical\nand\tO\nscreened\tO\nin\tO\nthe\tO\nDepartment\tO\nof\tO\nOphthalmology\tO\nwere\tO\nreviewed\tO\n.\tO\n\nOf\tO\nthe\tO\n262\tO\npatients\tO\n,\tO\n14\tO\n(\tO\n18\tO\n%\tO\n)\tO\nof\tO\n76\tO\nwho\tO\nhad\tO\nstopped\tO\ntreatment\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\nthe\tO\nstudy\tO\nexperienced\tO\ndocumented\tO\nadverse\tO\neffects\tO\n.\tO\n\nSystemic\tO\nadverse\tO\neffects\tO\noccurred\tO\nin\tO\n8\tO\npatients\tO\n(\tO\n10\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\nocular\tO\nadverse\tO\neffects\tO\n,\tO\nin\tO\n5\tO\n(\tO\n6\tO\n.\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\npatients\tO\n(\tO\n13\tO\n.\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nvisual\tB-Disease\nfield\tI-Disease\nabnormalities\tI-Disease\n,\tO\nwhich\tO\nwere\tO\nattributed\tO\nto\tO\nhydroxychloroquine\tB-Chemical\ntreatment\tO\nin\tO\n4\tO\npatients\tO\n(\tO\n1\tO\n.\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nThree\tO\nof\tO\nthe\tO\n4\tO\npatients\tO\nwere\tO\ntaking\tO\nless\tO\nthan\tO\n6\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\nand\tO\nall\tO\npatients\tO\nhad\tO\nnormal\tO\nrenal\tO\nand\tO\nliver\tO\nfunction\tO\ntest\tO\nresults\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncurrent\tO\nstudy\tO\nused\tO\na\tO\nprotocol\tO\nof\tO\nvisual\tO\nacuity\tO\nand\tO\ncolor\tO\nvision\tO\nassessment\tO\n,\tO\nfunduscopy\tO\n,\tO\nand\tO\nHumphrey\tO\n10\tO\n-\tO\n2\tO\nvisual\tO\nfield\tO\ntesting\tO\nand\tO\nshows\tO\nthat\tO\nvisual\tB-Disease\nfield\tI-Disease\ndefects\tI-Disease\nappeared\tO\nbefore\tO\nany\tO\ncorresponding\tO\nchanges\tO\nin\tO\nany\tO\nother\tO\ntested\tO\nclinical\tO\nparameters\tO\n;\tO\nthe\tO\ndefects\tO\nwere\tO\nreproducible\tO\nand\tO\nthe\tO\ntest\tO\nparameters\tO\nwere\tO\nreliable\tO\n.\tO\n\nPatients\tO\ntaking\tO\nhydroxychloroquine\tB-Chemical\ncan\tO\ndemonstrate\tO\na\tO\ntoxic\tO\nreaction\tO\nin\tO\nthe\tO\nretina\tO\ndespite\tO\nthe\tO\nabsence\tO\nof\tO\nknown\tO\nrisk\tO\nfactors\tO\n.\tO\n\nScreening\tO\n,\tO\nincluding\tO\nHumphrey\tO\n10\tO\n-\tO\n2\tO\nvisual\tO\nfield\tO\nassessment\tO\n,\tO\nis\tO\nrecommended\tO\n2\tO\nyears\tO\nafter\tO\nthe\tO\ninitial\tO\nbaseline\tO\nand\tO\nyearly\tO\nthereafter\tO\n.\tO\n\nPeri\tO\n-\tO\noperative\tO\natrioventricular\tB-Disease\nblock\tI-Disease\nas\tO\na\tO\nresult\tO\nof\tO\nchemotherapy\tO\nwith\tO\nepirubicin\tB-Chemical\nand\tO\npaclitaxel\tB-Chemical\n.\tO\n\nA\tO\n47\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\npresented\tO\nfor\tO\nmastectomy\tO\nand\tO\nimmediate\tO\nlatissimus\tO\ndorsi\tO\nflap\tO\nreconstruction\tO\nhaving\tO\nbeen\tO\ndiagnosed\tO\nwith\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nbreast\tI-Disease\n6\tO\nmonths\tO\npreviously\tO\n.\tO\n\nIn\tO\nthe\tO\npreceding\tO\nmonths\tO\nshe\tO\nhad\tO\nreceived\tO\nneo\tO\n-\tO\nadjuvant\tO\nchemotherapy\tO\nwith\tO\nepirubicin\tB-Chemical\n,\tO\npaclitaxel\tB-Chemical\n(\tO\nTaxol\tB-Chemical\n)\tO\nand\tO\ncyclophosphamide\tB-Chemical\n.\tO\n\nThis\tO\nhad\tO\nbeen\tO\napparently\tO\nuncomplicated\tO\nand\tO\nshe\tO\nhad\tO\nmaintained\tO\na\tO\nremarkably\tO\nhigh\tO\nlevel\tO\nof\tO\nphysical\tO\nactivity\tO\n.\tO\n\nShe\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\nbradycardic\tB-Disease\nat\tO\npre\tO\n-\tO\noperative\tO\nassessment\tO\nbut\tO\nhad\tO\nno\tO\ncardiac\tO\nsymptoms\tO\n.\tO\n\nSecond\tO\ndegree\tO\nMobitz\tO\ntype\tO\nII\tO\natrioventricular\tB-Disease\nblock\tI-Disease\nwas\tO\ndiagnosed\tO\non\tO\nelectrocardiogram\tO\n,\tO\nand\tO\ntemporary\tO\ntransvenous\tO\nventricular\tO\npacing\tO\ninstituted\tO\nin\tO\nthe\tO\nperi\tO\n-\tO\noperative\tO\nperiod\tO\n.\tO\n\nWe\tO\ndiscuss\tO\nhow\tO\nevidence\tO\n-\tO\nbased\tO\nguidelines\tO\nwould\tO\nnot\tO\nhave\tO\nbeen\tO\nhelpful\tO\nin\tO\nthis\tO\ncase\tO\n,\tO\nand\tO\nhow\tO\nchemotherapy\tO\ncan\tO\nexhibit\tO\nsubstantial\tO\ncardiotoxicity\tB-Disease\nthat\tO\nmay\tO\ndevelop\tO\nover\tO\nmany\tO\nyears\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\npatients\tO\nwho\tO\nhave\tO\nreceived\tO\nchemotherapy\tO\nat\tO\nany\tO\ntime\tO\nshould\tO\nhave\tO\na\tO\npre\tO\n-\tO\noperative\tO\nelectrocardiogram\tO\neven\tO\nif\tO\nthey\tO\nare\tO\nasymptomatic\tO\n.\tO\n\nRisks\tO\nand\tO\nbenefits\tO\nof\tO\nCOX\tB-Chemical\n-\tI-Chemical\n2\tI-Chemical\ninhibitors\tI-Chemical\nvs\tO\nnon\tO\n-\tO\nselective\tO\nNSAIDs\tO\n:\tO\ndoes\tO\ntheir\tO\ncardiovascular\tO\nrisk\tO\nexceed\tO\ntheir\tO\ngastrointestinal\tO\nbenefit\tO\n?\tO\n\nA\tO\nretrospective\tO\ncohort\tO\nstudy\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nrisk\tO\nof\tO\nacute\tB-Disease\nmyocardial\tI-Disease\ninfarction\tI-Disease\n(\tO\nAMI\tB-Disease\n)\tO\nwith\tO\nCOX\tB-Chemical\n-\tI-Chemical\n2\tI-Chemical\ninhibitors\tI-Chemical\nmay\tO\noffset\tO\ntheir\tO\ngastrointestinal\tO\n(\tO\nGI\tO\n)\tO\nbenefit\tO\ncompared\tO\nwith\tO\nnon\tO\n-\tO\nselective\tO\n(\tO\nNS\tO\n)\tO\nnon\tB-Chemical\n-\tI-Chemical\nsteroidal\tI-Chemical\nanti\tI-Chemical\n-\tI-Chemical\ninflammatory\tI-Chemical\ndrugs\tI-Chemical\n(\tO\nNSAIDs\tO\n)\tO\n.\tO\n\nWe\tO\naimed\tO\nto\tO\ncompare\tO\nthe\tO\nrisks\tO\nof\tO\nhospitalization\tO\nfor\tO\nAMI\tB-Disease\nand\tO\nGI\tB-Disease\nbleeding\tI-Disease\namong\tO\nelderly\tO\npatients\tO\nusing\tO\nCOX\tB-Chemical\n-\tI-Chemical\n2\tI-Chemical\ninhibitors\tI-Chemical\n,\tO\nNS\tO\n-\tO\nNSAIDs\tO\nand\tO\nacetaminophen\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nconducted\tO\na\tO\nretrospective\tO\ncohort\tO\nstudy\tO\nusing\tO\nadministrative\tO\ndata\tO\nof\tO\npatients\tO\n>\tO\nor\tO\n=\tO\n65\tO\nyears\tO\nof\tO\nage\tO\nwho\tO\nfilled\tO\na\tO\nprescription\tO\nfor\tO\nNSAID\tO\nor\tO\nacetaminophen\tB-Chemical\nduring\tO\n1999\tO\n-\tO\n2002\tO\n.\tO\n\nOutcomes\tO\nwere\tO\ncompared\tO\nusing\tO\nCox\tO\nregression\tO\nmodels\tO\nwith\tO\ntime\tO\n-\tO\ndependent\tO\nexposures\tO\n.\tO\n\nRESULTS\tO\n:\tO\nPerson\tO\n-\tO\nyears\tO\nof\tO\nexposure\tO\namong\tO\nnon\tO\n-\tO\nusers\tO\nof\tO\naspirin\tB-Chemical\nwere\tO\n:\tO\n75\tO\n,\tO\n761\tO\nto\tO\nacetaminophen\tB-Chemical\n,\tO\n42\tO\n,\tO\n671\tO\nto\tO\nrofecoxib\tB-Chemical\n65\tO\n,\tO\n860\tO\nto\tO\ncelecoxib\tB-Chemical\n,\tO\nand\tO\n37\tO\n,\tO\n495\tO\nto\tO\nNS\tO\n-\tO\nNSAIDs\tO\n.\tO\n\nAmong\tO\nusers\tO\nof\tO\naspirin\tB-Chemical\n,\tO\nthey\tO\nwere\tO\n:\tO\n14\tO\n,\tO\n671\tO\nto\tO\nrofecoxib\tB-Chemical\n,\tO\n22\tO\n,\tO\n875\tO\nto\tO\ncelecoxib\tB-Chemical\n,\tO\n9\tO\n,\tO\n832\tO\nto\tO\nNS\tO\n-\tO\nNSAIDs\tO\nand\tO\n38\tO\n,\tO\n048\tO\nto\tO\nacetaminophen\tB-Chemical\n.\tO\n\nAmong\tO\nnon\tO\n-\tO\nusers\tO\nof\tO\naspirin\tB-Chemical\n,\tO\nthe\tO\nadjusted\tO\nhazard\tO\nratios\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n)\tO\nof\tO\nhospitalization\tO\nfor\tO\nAMI\tB-Disease\n/\tO\nGI\tO\nvs\tO\nthe\tO\nacetaminophen\tB-Chemical\n(\tO\nwith\tO\nno\tO\naspirin\tB-Chemical\n)\tO\ngroup\tO\nwere\tO\n:\tO\nrofecoxib\tB-Chemical\n1\tO\n.\tO\n27\tO\n(\tO\n1\tO\n.\tO\n13\tO\n,\tO\n1\tO\n.\tO\n42\tO\n)\tO\n,\tO\ncelecoxib\tB-Chemical\n0\tO\n.\tO\n93\tO\n(\tO\n0\tO\n.\tO\n83\tO\n,\tO\n1\tO\n.\tO\n03\tO\n)\tO\n,\tO\nnaproxen\tB-Chemical\n1\tO\n.\tO\n59\tO\n(\tO\n1\tO\n.\tO\n31\tO\n,\tO\n1\tO\n.\tO\n93\tO\n)\tO\n,\tO\ndiclofenac\tB-Chemical\n1\tO\n.\tO\n17\tO\n(\tO\n0\tO\n.\tO\n99\tO\n,\tO\n1\tO\n.\tO\n38\tO\n)\tO\nand\tO\nibuprofen\tB-Chemical\n1\tO\n.\tO\n05\tO\n(\tO\n0\tO\n.\tO\n74\tO\n,\tO\n1\tO\n.\tO\n51\tO\n)\tO\n.\tO\n\nAmong\tO\nusers\tO\nof\tO\naspirin\tB-Chemical\n,\tO\nthey\tO\nwere\tO\n:\tO\nrofecoxib\tB-Chemical\n1\tO\n.\tO\n73\tO\n(\tO\n1\tO\n.\tO\n52\tO\n,\tO\n1\tO\n.\tO\n98\tO\n)\tO\n,\tO\ncelecoxib\tB-Chemical\n1\tO\n.\tO\n34\tO\n(\tO\n1\tO\n.\tO\n19\tO\n,\tO\n1\tO\n.\tO\n52\tO\n)\tO\n,\tO\nibuprofen\tB-Chemical\n1\tO\n.\tO\n51\tO\n(\tO\n0\tO\n.\tO\n95\tO\n,\tO\n2\tO\n.\tO\n41\tO\n)\tO\n,\tO\ndiclofenac\tB-Chemical\n1\tO\n.\tO\n69\tO\n(\tO\n1\tO\n.\tO\n35\tO\n,\tO\n2\tO\n.\tO\n10\tO\n)\tO\n,\tO\nnaproxen\tB-Chemical\n1\tO\n.\tO\n35\tO\n(\tO\n0\tO\n.\tO\n97\tO\n,\tO\n1\tO\n.\tO\n88\tO\n)\tO\nand\tO\nacetaminophen\tB-Chemical\n1\tO\n.\tO\n29\tO\n(\tO\n1\tO\n.\tO\n17\tO\n,\tO\n1\tO\n.\tO\n42\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nAmong\tO\nnon\tO\n-\tO\nusers\tO\nof\tO\naspirin\tB-Chemical\n,\tO\nnaproxen\tB-Chemical\nseemed\tO\nto\tO\ncarry\tO\nthe\tO\nhighest\tO\nrisk\tO\nfor\tO\nAMI\tB-Disease\n/\tO\nGI\tB-Disease\nbleeding\tI-Disease\n.\tO\n\nThe\tO\nAMI\tB-Disease\n/\tO\nGI\tO\ntoxicity\tB-Disease\nof\tO\ncelecoxib\tB-Chemical\nwas\tO\nsimilar\tO\nto\tO\nthat\tO\nof\tO\nacetaminophen\tB-Chemical\nand\tO\nseemed\tO\nto\tO\nbe\tO\nbetter\tO\nthan\tO\nthose\tO\nof\tO\nrofecoxib\tB-Chemical\nand\tO\nNS\tO\n-\tO\nNSAIDs\tO\n.\tO\n\nAmong\tO\nusers\tO\nof\tO\naspirin\tB-Chemical\n,\tO\nboth\tO\ncelecoxib\tB-Chemical\nand\tO\nnaproxen\tB-Chemical\nseemed\tO\nto\tO\nbe\tO\nthe\tO\nleast\tO\ntoxic\tO\n.\tO\n\nQuinine\tB-Chemical\n-\tO\ninduced\tO\narrhythmia\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nsevere\tB-Disease\nmalaria\tI-Disease\n.\tO\n\nIt\tO\nwas\tO\nreported\tO\nthat\tO\nthere\tO\nwas\tO\na\tO\ncase\tO\nof\tO\nsevere\tB-Disease\nmalaria\tI-Disease\npatient\tO\nwith\tO\njaundice\tB-Disease\nwho\tO\npresented\tO\nwith\tO\narrhythmia\tB-Disease\n(\tO\npremature\tB-Disease\nventricular\tI-Disease\ncontraction\tI-Disease\n)\tO\nwhile\tO\ngetting\tO\nquinine\tB-Chemical\ninfusion\tO\nwas\tO\nreported\tO\n.\tO\n\nA\tO\nman\tO\n,\tO\n25\tO\nyears\tO\nold\tO\n,\tO\nwas\tO\nadmitted\tO\nto\tO\nhospital\tO\nwith\tO\nhigh\tO\nfever\tB-Disease\n,\tO\nchill\tB-Disease\n,\tO\nvomiting\tB-Disease\n,\tO\njaundice\tB-Disease\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nfully\tO\nconscious\tO\n,\tO\nblood\tO\npressure\tO\n120\tO\n/\tO\n80\tO\nmmHg\tO\n,\tO\npulse\tO\nrate\tO\n100\tO\nx\tO\n/\tO\nminute\tO\n,\tO\nregular\tO\n.\tO\n\nOn\tO\nadmission\tO\n,\tO\nlaboratory\tO\nexamination\tO\nshowed\tO\nPlasmodium\tO\nfalciparum\tO\n(\tO\n+\tO\n+\tO\n+\tO\n+\tO\n)\tO\n,\tO\ntotal\tO\nbilirubin\tB-Chemical\n8\tO\n.\tO\n25\tO\nmg\tO\n/\tO\ndL\tO\n,\tO\nconjugated\tO\nbilirubin\tB-Chemical\n4\tO\n.\tO\n36\tO\nmg\tO\n/\tO\ndL\tO\n,\tO\nunconjugated\tO\nbilirubin\tB-Chemical\n3\tO\n.\tO\n89\tO\nmg\tO\n/\tO\ndL\tO\n,\tO\npotassium\tB-Chemical\n3\tO\n.\tO\n52\tO\nmeq\tO\n/\tO\nL\tO\nPatient\tO\nwas\tO\ndiagnosed\tO\nas\tO\nsevere\tB-Disease\nmalaria\tI-Disease\nwith\tO\njaundice\tB-Disease\nand\tO\ngot\tO\nquinine\tB-Chemical\ninfusion\tO\nin\tO\ndextrose\tB-Chemical\n5\tO\n%\tO\n500\tO\nmg\tO\n/\tO\n8\tO\nhour\tO\n.\tO\n\nOn\tO\nthe\tO\nsecond\tO\nday\tO\nthe\tO\npatient\tO\nhad\tO\nvomitus\tB-Disease\n,\tO\ndiarrhea\tB-Disease\n,\tO\ntinnitus\tB-Disease\n,\tO\nloss\tB-Disease\nof\tI-Disease\nhearing\tI-Disease\n.\tO\n\nAfter\tO\n30\tO\nhours\tO\nof\tO\nquinine\tB-Chemical\ninfusion\tO\nthe\tO\npatient\tO\nfelt\tO\npalpitation\tB-Disease\nand\tO\nelectrocardiography\tO\n(\tO\nECG\tO\n)\tO\nrecording\tO\nshowed\tO\npremature\tB-Disease\nventricular\tI-Disease\ncontraction\tI-Disease\n(\tO\nPVC\tB-Disease\n)\tO\n>\tO\n5\tO\nx\tO\n/\tO\nminute\tO\n,\tO\ntrigemini\tO\n,\tO\nconstant\tO\ntype\tO\n-\tO\n-\tO\nsinoatrial\tB-Disease\nblock\tI-Disease\n,\tO\npositive\tO\nU\tO\nwave\tO\n.\tO\n\nHe\tO\nwas\tO\ntreated\tO\nwith\tO\nlidocaine\tB-Chemical\n50\tO\nmg\tO\nintravenously\tO\nfollowed\tO\nby\tO\ninfusion\tO\n1500\tO\nmg\tO\nin\tO\ndextrose\tB-Chemical\n5\tO\n%\tO\n/\tO\n24\tO\nhour\tO\nand\tO\npotassium\tB-Chemical\naspartate\tI-Chemical\ntablet\tO\n.\tO\n\nQuinine\tB-Chemical\ninfusion\tO\nwas\tO\ndiscontinued\tO\nand\tO\nchanged\tO\nwith\tO\nsulfate\tO\nquinine\tB-Chemical\ntablets\tO\n.\tO\n\nThree\tO\nhours\tO\nlater\tO\nthe\tO\npatient\tO\nfelt\tO\nbetter\tO\n,\tO\nthe\tO\nfrequency\tO\nof\tO\nPVC\tB-Disease\nreduced\tO\nto\tO\n4\tO\n-\tO\n5\tO\nx\tO\n/\tO\nminute\tO\nand\tO\non\tO\nthe\tO\nthird\tO\nday\tO\nECG\tO\nwas\tO\nnormal\tO\n,\tO\npotassium\tB-Chemical\nlevel\tO\nwas\tO\n3\tO\n.\tO\n34\tO\nmeq\tO\n/\tO\nL\tO\n.\tO\n\nHe\tO\nwas\tO\ndischarged\tO\non\tO\n7th\tO\nday\tO\nin\tO\ngood\tO\ncondition\tO\n.\tO\n\nQuinine\tB-Chemical\n,\tO\nlike\tO\nquinidine\tB-Chemical\n,\tO\nis\tO\na\tO\nchincona\tO\nalkaloid\tO\nthat\tO\nhas\tO\nanti\tO\n-\tO\narrhythmic\tB-Disease\nproperty\tO\n,\tO\nalthough\tO\nit\tO\nalso\tO\npro\tO\n-\tO\narrhythmic\tB-Disease\nthat\tO\ncan\tO\ncause\tO\nvarious\tO\narrhythmias\tB-Disease\n,\tO\nincluding\tO\nsevere\tO\narrhythmia\tB-Disease\nsuch\tO\nas\tO\nmultiple\tO\nPVC\tB-Disease\n.\tO\n\nAdministration\tO\nof\tO\nparenteral\tO\nquinine\tB-Chemical\nmust\tO\nbe\tO\ndone\tO\ncarefully\tO\nand\tO\nwith\tO\ngood\tO\nobservation\tO\nbecause\tO\nof\tO\nits\tO\npro\tO\n-\tO\narrhythmic\tB-Disease\neffect\tO\n,\tO\nespecially\tO\nin\tO\nolder\tO\npatients\tO\nwho\tO\nhave\tO\nheart\tB-Disease\ndiseases\tI-Disease\nor\tO\npatients\tO\nwith\tO\nelectrolyte\tB-Disease\ndisorder\tI-Disease\n(\tO\nhypokalemia\tB-Disease\n)\tO\nwhich\tO\nfrequently\tO\noccurs\tO\ndue\tO\nto\tO\nvomiting\tB-Disease\nand\tO\nor\tO\ndiarrhea\tB-Disease\nin\tO\nmalaria\tB-Disease\ncases\tO\n.\tO\n\nPenicillamine\tB-Chemical\n-\tO\nrelated\tO\nlichenoid\tB-Disease\ndermatitis\tI-Disease\nand\tO\nutility\tO\nof\tO\nzinc\tB-Chemical\nacetate\tI-Chemical\nin\tO\na\tO\nWilson\tB-Disease\ndisease\tI-Disease\npatient\tO\nwith\tO\nhepatic\tO\npresentation\tO\n,\tO\nanxiety\tB-Disease\nand\tO\nSPECT\tO\nabnormalities\tO\n.\tO\n\nWilson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nis\tO\nan\tO\nautosomal\tO\nrecessive\tO\ndisorder\tO\nof\tO\nhepatic\tO\ncopper\tB-Chemical\nmetabolism\tO\nwith\tO\nconsequent\tO\ncopper\tB-Chemical\naccumulation\tO\nand\tO\ntoxicity\tB-Disease\nin\tO\nmany\tO\ntissues\tO\nand\tO\nconsequent\tO\nhepatic\tB-Disease\n,\tI-Disease\nneurologic\tI-Disease\nand\tI-Disease\npsychiatric\tI-Disease\ndisorders\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nWilson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nwith\tO\nchronic\tB-Disease\nliver\tI-Disease\ndisease\tI-Disease\n;\tO\nmoreover\tO\n,\tO\nin\tO\nour\tO\npatient\tO\n,\tO\npresenting\tO\nalso\tO\nwith\tO\nhigh\tO\nlevels\tO\nof\tO\nstate\tO\nanxiety\tB-Disease\nwithout\tO\ndepression\tB-Disease\n,\tO\n99mTc\tO\n-\tO\nECD\tO\n-\tO\nSPECT\tO\nshowed\tO\ncortical\tO\nhypoperfusion\tO\nin\tO\nfrontal\tO\nlobes\tO\n,\tO\nmore\tO\nmarked\tO\non\tO\nthe\tO\nleft\tO\nfrontal\tO\nlobe\tO\n.\tO\n\nDuring\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\nour\tO\npatient\tO\n,\tO\npenicillamine\tB-Chemical\nwas\tO\ninterrupted\tO\nafter\tO\nthe\tO\nappearance\tO\nof\tO\na\tO\nlichenoid\tB-Disease\ndermatitis\tI-Disease\n,\tO\nand\tO\nzinc\tB-Chemical\nacetate\tI-Chemical\npermitted\tO\nto\tO\ncontinue\tO\nthe\tO\nsuccessful\tO\ntreatment\tO\nof\tO\nthe\tO\npatient\tO\nwithout\tO\nside\tO\n-\tO\neffects\tO\n.\tO\n\nIn\tO\nour\tO\ncase\tO\nthe\tO\ntherapy\tO\nwith\tO\nzinc\tB-Chemical\nacetate\tI-Chemical\nrepresented\tO\nan\tO\neffective\tO\ntreatment\tO\nfor\tO\na\tO\nWilson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\npatient\tO\nin\tO\nwhich\tO\npenicillamine\tB-Chemical\n-\tO\nrelated\tO\nside\tO\neffects\tO\nappeared\tO\n.\tO\n\nThe\tO\nsafety\tO\nof\tO\nthe\tO\nzinc\tB-Chemical\nacetate\tI-Chemical\nallowed\tO\nus\tO\nto\tO\navoid\tO\nother\tO\npotentially\tO\ntoxic\tO\nchelating\tO\ndrugs\tO\n;\tO\nthis\tO\nobservation\tO\nis\tO\nin\tO\nline\tO\nwith\tO\nthe\tO\ngrowing\tO\nevidence\tO\non\tO\nthe\tO\nefficacy\tO\nof\tO\nthe\tO\ndrug\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nWilson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nSince\tO\nmost\tO\nof\tO\nWilson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\npenicillamine\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\ndo\tO\nnot\tO\nseem\tO\nto\tO\ndevelop\tO\nthis\tO\nskin\tB-Disease\nlesion\tI-Disease\n,\tO\nit\tO\ncould\tO\nbe\tO\nconceivable\tO\nthat\tO\na\tO\nspecific\tO\ngenetic\tO\nfactor\tO\nis\tO\ninvolved\tO\nin\tO\ndrug\tO\nresponse\tO\n.\tO\n\nFurther\tO\nstudies\tO\nare\tO\nneeded\tO\nfor\tO\na\tO\nbetter\tO\nclarification\tO\nof\tO\nWilson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\ntherapy\tO\n,\tO\nand\tO\nin\tO\nparticular\tO\nto\tO\ndifferentiate\tO\nspecific\tO\ntherapies\tO\nfor\tO\ndifferent\tO\nWilson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nphenotypes\tO\n.\tO\n\nA\tO\ndramatic\tO\ndrop\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nfollowing\tO\nprehospital\tO\nGTN\tB-Chemical\nadministration\tO\n.\tO\n\nA\tO\nmale\tO\nin\tO\nhis\tO\nsixties\tO\nwith\tO\nno\tO\nhistory\tO\nof\tO\ncardiac\tO\nchest\tB-Disease\npain\tI-Disease\nawoke\tO\nwith\tO\nchest\tB-Disease\npain\tI-Disease\nfollowing\tO\nan\tO\nafternoon\tO\nsleep\tO\n.\tO\n\nThe\tO\npatient\tO\ndid\tO\nnot\tO\nself\tO\nmedicate\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nobservations\tO\nwere\tO\nwithin\tO\nnormal\tO\nlimits\tO\n,\tO\nhe\tO\nwas\tO\nadministered\tO\noxygen\tB-Chemical\nvia\tO\na\tO\nface\tO\nmask\tO\nand\tO\nglyceryl\tB-Chemical\ntrinitrate\tI-Chemical\n(\tO\nGTN\tB-Chemical\n)\tO\n.\tO\n\nSeveral\tO\nminutes\tO\nafter\tO\nthe\tO\nGTN\tB-Chemical\nthe\tO\npatient\tO\nexperienced\tO\na\tO\nsudden\tO\ndrop\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nand\tO\nheart\tO\nrate\tO\n,\tO\nthis\tO\nwas\tO\nrectified\tO\nby\tO\natropine\tB-Chemical\nsulphate\tI-Chemical\nand\tO\na\tO\nfluid\tO\nchallenge\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nfurther\tO\ndeterioration\tO\nin\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\ncondition\tO\nduring\tO\ntransport\tO\nto\tO\nhospital\tO\n.\tO\n\nThere\tO\nare\tO\nvery\tO\nfew\tO\ndocumented\tO\ncase\tO\nlike\tO\nthis\tO\nin\tO\nthe\tO\nprehospital\tO\nscientific\tO\nliterature\tO\n.\tO\n\nThe\tO\ncause\tO\nappears\tO\nto\tO\nbe\tO\nthe\tO\nBezold\tO\n-\tO\nJarish\tO\nreflex\tO\n,\tO\nstimulation\tO\nof\tO\nthe\tO\nventricular\tO\nwalls\tO\nwhich\tO\nin\tO\nturn\tO\ndecreases\tO\nsympathetic\tO\noutflow\tO\nfrom\tO\nthe\tO\nvasomotor\tO\ncentre\tO\n.\tO\n\nPrehospital\tO\ncare\tO\nproviders\tO\nwho\tO\nare\tO\nmanaging\tO\nany\tO\npatient\tO\nwith\tO\na\tO\nsyncopal\tB-Disease\nepisode\tI-Disease\nthat\tO\nfails\tO\nto\tO\nrecover\tO\nwithin\tO\na\tO\nreasonable\tO\ntime\tO\nframe\tO\nshould\tO\nconsider\tO\nthe\tO\nBezold\tO\n-\tO\nJarisch\tO\nreflex\tO\nas\tO\nthe\tO\ncause\tO\nand\tO\nmanage\tO\nthe\tO\npatient\tO\naccordingly\tO\n.\tO\n\nChronic\tO\nlesion\tO\nof\tO\nrostral\tO\nventrolateral\tO\nmedulla\tO\nin\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n.\tO\n\nWe\tO\nstudied\tO\nthe\tO\neffects\tO\nof\tO\nchronic\tO\nselective\tO\nneuronal\tO\nlesion\tO\nof\tO\nrostral\tO\nventrolateral\tO\nmedulla\tO\non\tO\nmean\tO\narterial\tO\npressure\tO\n,\tO\nheart\tO\nrate\tO\n,\tO\nand\tO\nneurogenic\tO\ntone\tO\nin\tO\nconscious\tO\n,\tO\nunrestrained\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n.\tO\n\nThe\tO\nlesions\tO\nwere\tO\nplaced\tO\nvia\tO\nbilateral\tO\nmicroinjections\tO\nof\tO\n30\tO\nnmol\tO\n/\tO\n200\tO\nnl\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartic\tI-Chemical\nacid\tI-Chemical\n.\tO\n\nThe\tO\nrestimulation\tO\nof\tO\nthis\tO\narea\tO\nwith\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartic\tI-Chemical\nacid\tI-Chemical\n15\tO\ndays\tO\npostlesion\tO\nfailed\tO\nto\tO\nproduce\tO\na\tO\npressor\tO\nresponse\tO\n.\tO\n\nOne\tO\nday\tO\npostlesion\tO\n,\tO\nthe\tO\nresting\tO\nmean\tO\narterial\tO\npressure\tO\nwas\tO\nsignificantly\tO\ndecreased\tO\nin\tO\nlesioned\tO\nrats\tO\nwhen\tO\ncompared\tO\nwith\tO\nsham\tO\nrats\tO\n(\tO\n100\tO\n+\tO\n/\tO\n-\tO\n7\tO\nversus\tO\n173\tO\n+\tO\n/\tO\n-\tO\n4\tO\nmm\tO\nHg\tO\n,\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nFifteen\tO\ndays\tO\nlater\tO\n,\tO\nthe\tO\nlesioned\tO\ngroup\tO\nstill\tO\nshowed\tO\nvalues\tO\nsignificantly\tO\nlower\tO\nthan\tO\nthe\tO\nsham\tO\ngroup\tO\n(\tO\n150\tO\n+\tO\n/\tO\n-\tO\n6\tO\nversus\tO\n167\tO\n+\tO\n/\tO\n-\tO\n5\tO\nmm\tO\nHg\tO\n,\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nNo\tO\nsignificant\tO\nheart\tO\nrate\tO\ndifferences\tO\nwere\tO\nobserved\tO\nbetween\tO\nthe\tO\nsham\tO\nand\tO\nlesioned\tO\ngroups\tO\n.\tO\n\nThe\tO\nganglionic\tO\nblocker\tO\ntrimethaphan\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\ncaused\tO\nsimilar\tO\nreductions\tO\nin\tO\nmean\tO\narterial\tO\npressure\tO\nin\tO\nboth\tO\nlesioned\tO\nand\tO\nsham\tO\ngroups\tO\n.\tO\n\nThe\tO\ntrimethaphan\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nwas\tO\naccompanied\tO\nby\tO\na\tO\nsignificant\tO\nbradycardia\tB-Disease\nin\tO\nlesioned\tO\nrats\tO\n(\tO\n-\tO\n32\tO\n+\tO\n/\tO\n-\tO\n13\tO\nbeats\tO\nper\tO\nminute\tO\n)\tO\nbut\tO\na\tO\ntachycardia\tB-Disease\nin\tO\nsham\tO\nrats\tO\n(\tO\n+\tO\n33\tO\n+\tO\n/\tO\n-\tO\n12\tO\nbeats\tO\nper\tO\nminute\tO\n)\tO\n1\tO\nday\tO\npostlesion\tO\n.\tO\n\nTherefore\tO\n,\tO\nrostral\tO\nventrolateral\tO\nmedulla\tO\nneurons\tO\nappear\tO\nto\tO\nplay\tO\na\tO\nsignificant\tO\nrole\tO\nin\tO\nmaintaining\tO\nhypertension\tB-Disease\nin\tO\nconscious\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n.\tO\n\nSpinal\tO\nor\tO\nsuprabulbar\tO\nstructures\tO\ncould\tO\nbe\tO\nresponsible\tO\nfor\tO\nthe\tO\ngradual\tO\nrecovery\tO\nof\tO\nthe\tO\nhypertension\tB-Disease\nin\tO\nthe\tO\nlesioned\tO\nrats\tO\n.\tO\n\nAcute\tB-Disease\nencephalopathy\tI-Disease\nand\tO\ncerebral\tB-Disease\nvasospasm\tI-Disease\nafter\tO\nmultiagent\tO\nchemotherapy\tO\nincluding\tO\nPEG\tB-Chemical\n-\tI-Chemical\nasparaginase\tI-Chemical\nand\tO\nintrathecal\tO\ncytarabine\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\n.\tO\n\nA\tO\n7\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ngirl\tO\nwith\tO\nan\tO\nunusual\tO\nreaction\tO\nto\tO\ninduction\tO\nchemotherapy\tO\nfor\tO\nprecursor\tO\nB\tO\n-\tO\ncell\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\n(\tO\nALL\tB-Disease\n)\tO\nis\tO\ndescribed\tO\n.\tO\n\nThe\tO\npatient\tO\ndeveloped\tO\nacute\tB-Disease\nencephalopathy\tI-Disease\nevidenced\tO\nby\tO\nbehavioral\tO\nchanges\tO\n,\tO\naphasia\tB-Disease\n,\tO\nincontinence\tB-Disease\n,\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\n,\tO\nand\tO\nright\tO\n-\tO\nsided\tO\nweakness\tB-Disease\nwith\tO\ndiffuse\tO\ncerebral\tB-Disease\nvasospasm\tI-Disease\non\tO\nmagnetic\tO\nresonance\tO\nangiography\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\nintrathecal\tO\ncytarabine\tB-Chemical\n.\tO\n\nVincristine\tB-Chemical\n,\tO\ndexamethasone\tB-Chemical\n,\tO\nand\tO\npolyethylene\tB-Chemical\nglycol\tI-Chemical\n-\tI-Chemical\nasparaginase\tI-Chemical\nwere\tO\nalso\tO\nadministered\tO\nbefore\tO\nthe\tO\nepisode\tO\nas\tO\npart\tO\nof\tO\ninduction\tO\ntherapy\tO\n.\tO\n\nNeurologic\tO\nstatus\tO\nreturned\tO\nto\tO\nbaseline\tO\nwithin\tO\n10\tO\ndays\tO\nof\tO\nthe\tO\nacute\tO\nevent\tO\n,\tO\nand\tO\nmagnetic\tO\nresonance\tO\nangiography\tO\nfindings\tO\nreturned\tO\nto\tO\nnormal\tO\n4\tO\nmonths\tO\nlater\tO\n.\tO\n\nComparison\tO\nof\tO\nvalsartan\tB-Chemical\n/\tO\nhydrochlorothiazide\tB-Chemical\ncombination\tO\ntherapy\tO\nat\tO\ndoses\tO\nup\tO\nto\tO\n320\tO\n/\tO\n25\tO\nmg\tO\nversus\tO\nmonotherapy\tO\n:\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\nstudy\tO\nfollowed\tO\nby\tO\nlong\tO\n-\tO\nterm\tO\ncombination\tO\ntherapy\tO\nin\tO\nhypertensive\tB-Disease\nadults\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nOne\tO\nthird\tO\nof\tO\npatients\tO\ntreated\tO\nfor\tO\nhypertension\tB-Disease\nattain\tO\nadequate\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\ncontrol\tO\n,\tO\nand\tO\nmultidrug\tO\nregimens\tO\nare\tO\noften\tO\nrequired\tO\n.\tO\n\nGiven\tO\nthe\tO\nlifelong\tO\nnature\tO\nof\tO\nhypertension\tB-Disease\n,\tO\nthere\tO\nis\tO\na\tO\nneed\tO\nto\tO\nevaluate\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nefficacy\tO\nand\tO\ntolerability\tO\nof\tO\nhigher\tO\ndoses\tO\nof\tO\ncombination\tO\nanti\tO\n-\tO\nhypertensive\tB-Disease\ntherapies\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThis\tO\nstudy\tO\ninvestigated\tO\nthe\tO\nefficacy\tO\nand\tO\ntolerability\tO\nof\tO\nvalsartan\tB-Chemical\n(\tO\nVAL\tB-Chemical\n)\tO\nor\tO\nhydrochlorothiazide\tB-Chemical\n(\tO\nHCTZ\tB-Chemical\n)\tO\n-\tO\nmonotherapy\tO\nand\tO\nhigher\tO\n-\tO\ndose\tO\ncombinations\tO\nin\tO\npatients\tO\nwith\tO\nessential\tB-Disease\nhypertension\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nfirst\tO\npart\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nan\tO\n8\tO\n-\tO\nweek\tO\n,\tO\nmulticenter\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\ncontrolled\tO\n,\tO\nparallel\tO\n-\tO\ngroup\tO\ntrial\tO\n.\tO\n\nPatients\tO\nwith\tO\nessential\tB-Disease\nhypertension\tI-Disease\n(\tO\nmean\tO\nsitting\tO\ndiastolic\tO\nBP\tO\n[\tO\nMSDBP\tO\n]\tO\n,\tO\n>\tO\nor\tO\n=\tO\n95\tO\nmm\tO\nHg\tO\nand\tO\n<\tO\n110\tO\nmm\tO\nHg\tO\n)\tO\nwere\tO\nrandomized\tO\nto\tO\n1\tO\nof\tO\n8\tO\ntreatment\tO\ngroups\tO\n:\tO\nVAL\tB-Chemical\n160\tO\nor\tO\n320\tO\nmg\tO\n;\tO\nHCTZ\tB-Chemical\n12\tO\n.\tO\n5\tO\nor\tO\n25\tO\nmg\tO\n;\tO\nVAL\tB-Chemical\n/\tO\nHCTZ\tB-Chemical\n160\tO\n/\tO\n12\tO\n.\tO\n5\tO\n,\tO\n320\tO\n/\tO\n12\tO\n.\tO\n5\tO\n,\tO\nor\tO\n320\tO\n/\tO\n25\tO\nmg\tO\n;\tO\nor\tO\nplacebo\tO\n.\tO\n\nMean\tO\nchanges\tO\nin\tO\nMSDBP\tO\nand\tO\nmean\tO\nsitting\tO\nsystolic\tO\nBP\tO\n(\tO\nMSSBP\tO\n)\tO\nwere\tO\nanalyzed\tO\nat\tO\nthe\tO\n8\tO\n-\tO\nweek\tO\ncore\tO\nstudy\tO\nend\tO\npoint\tO\n.\tO\n\nVAL\tB-Chemical\n/\tO\nHCTZ\tB-Chemical\n320\tO\n/\tO\n12\tO\n.\tO\n5\tO\nand\tO\n320\tO\n/\tO\n25\tO\nmg\tO\nwere\tO\nfurther\tO\ninvestigated\tO\nin\tO\na\tO\n54\tO\n-\tO\nweek\tO\n,\tO\nopen\tO\n-\tO\nlabel\tO\nextension\tO\n.\tO\n\nResponse\tO\nwas\tO\ndefined\tO\nas\tO\nMSDBP\tO\n<\tO\n90\tO\nmm\tO\nHg\tO\nor\tO\na\tO\n>\tO\nor\tO\n=\tO\n10\tO\nmm\tO\nHg\tO\ndecrease\tO\ncompared\tO\nto\tO\nbaseline\tO\n.\tO\n\nControl\tO\nwas\tO\ndefined\tO\nas\tO\nMSDBP\tO\n<\tO\n90\tO\nmm\tO\nHg\tO\ncompared\tO\nwith\tO\nbaseline\tO\n.\tO\n\nTolerability\tO\nwas\tO\nassessed\tO\nby\tO\nmonitoring\tO\nadverse\tO\nevents\tO\nat\tO\nrandomization\tO\nand\tO\nall\tO\nsubsequent\tO\nstudy\tO\nvisits\tO\nand\tO\nregular\tO\nevaluation\tO\nof\tO\nhematology\tO\nand\tO\nblood\tO\nchemistry\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n1346\tO\npatients\tO\nwere\tO\nrandomized\tO\ninto\tO\nthe\tO\n8\tO\n-\tO\nweek\tO\ncore\tO\nstudy\tO\n(\tO\n734\tO\nmen\tO\n,\tO\n612\tO\nwomen\tO\n;\tO\n924\tO\nwhite\tO\n,\tO\n291\tO\nblack\tO\n,\tO\n23\tO\nAsian\tO\n,\tO\n108\tO\nother\tO\n;\tO\nmean\tO\nage\tO\n,\tO\n52\tO\n.\tO\n7\tO\nyears\tO\n;\tO\nmean\tO\nweight\tO\n,\tO\n92\tO\n.\tO\n6\tO\nkg\tO\n)\tO\n.\tO\n\nAll\tO\nactive\tO\ntreatments\tO\nwere\tO\nassociated\tO\nwith\tO\nsignificantly\tO\nreduced\tO\nMSSBP\tO\nand\tO\nMSDBP\tO\nduring\tO\nthe\tO\ncore\tO\n8\tO\n-\tO\nweek\tO\nstudy\tO\n,\tO\nwith\tO\neach\tO\nmonotherapy\tO\nsignificantly\tO\ncontributing\tO\nto\tO\nthe\tO\noverall\tO\neffect\tO\nof\tO\ncombination\tO\ntherapy\tO\n(\tO\nVAL\tB-Chemical\nand\tO\nHCTZ\tB-Chemical\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nEach\tO\ncombination\tO\nwas\tO\nassociated\tO\nwith\tO\nsignificantly\tO\ngreater\tO\nreductions\tO\nin\tO\nMSSBP\tO\nand\tO\nMSDBP\tO\ncompared\tO\nwith\tO\nthe\tO\nmonotherapies\tO\nand\tO\nplacebo\tO\n(\tO\nall\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nreduction\tO\nin\tO\nMSSBP\tO\n/\tO\nMSDBP\tO\nwith\tO\nVAL\tB-Chemical\n/\tO\nHCTZ\tB-Chemical\n320\tO\n/\tO\n25\tO\nmg\tO\nwas\tO\n24\tO\n.\tO\n7\tO\n/\tO\n16\tO\n.\tO\n6\tO\nmm\tO\nHg\tO\n,\tO\ncompared\tO\nwith\tO\n5\tO\n.\tO\n9\tO\n/\tO\n7\tO\n.\tO\n0\tO\nmm\tO\nHg\tO\nwith\tO\nplacebo\tO\n.\tO\n\nThe\tO\nreduction\tO\nin\tO\nMSSBP\tO\nwas\tO\nsignificantly\tO\ngreater\tO\nwith\tO\nVAL\tB-Chemical\n/\tO\nHCTZ\tB-Chemical\n320\tO\n/\tO\n25\tO\nmg\tO\ncompared\tO\nwith\tO\nVAL\tB-Chemical\n/\tO\nHCTZ\tB-Chemical\n160\tO\n/\tO\n12\tO\n.\tO\n5\tO\nmg\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nRates\tO\nof\tO\nresponse\tO\nand\tO\nBP\tO\ncontrol\tO\nwere\tO\nsignificantly\tO\nhigher\tO\nin\tO\nthe\tO\ngroups\tO\nthat\tO\nreceived\tO\ncombination\tO\ntreatment\tO\ncompared\tO\nwith\tO\nthose\tO\nthat\tO\nreceived\tO\nmonotherapy\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nhypokalemia\tB-Disease\nwas\tO\nlower\tO\nwith\tO\nVAL\tB-Chemical\n/\tO\nHCTZ\tB-Chemical\ncombinations\tO\n(\tO\n1\tO\n.\tO\n8\tO\n%\tO\n-\tO\n6\tO\n.\tO\n1\tO\n%\tO\n)\tO\nthan\tO\nwith\tO\nHCTZ\tB-Chemical\nmonotherapies\tO\n(\tO\n7\tO\n.\tO\n1\tO\n%\tO\n-\tO\n13\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmajority\tO\nof\tO\nadverse\tO\nevents\tO\nin\tO\nthe\tO\ncore\tO\nstudy\tO\nwere\tO\nof\tO\nmild\tO\nto\tO\nmoderate\tO\nseverity\tO\n.\tO\n\nThe\tO\nefficacy\tO\nand\tO\ntolerability\tO\nof\tO\nVAL\tB-Chemical\n/\tO\nHCTZ\tB-Chemical\ncombinations\tO\nwere\tO\nmaintained\tO\nduring\tO\nthe\tO\nextension\tO\n(\tO\n797\tO\npatients\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\nthis\tO\nstudy\tO\npopulation\tO\n,\tO\ncombination\tO\ntherapies\tO\nwith\tO\nVAL\tB-Chemical\n/\tO\nHCTZ\tB-Chemical\nwere\tO\nassociated\tO\nwith\tO\nsignificantly\tO\ngreater\tO\nBP\tO\nreductions\tO\ncompared\tO\nwith\tO\neither\tO\nmonotherapy\tO\n,\tO\nwere\tO\nwell\tO\ntolerated\tO\n,\tO\nand\tO\nwere\tO\nassociated\tO\nwith\tO\nless\tO\nhypokalemia\tB-Disease\nthan\tO\nHCTZ\tB-Chemical\nalone\tO\n.\tO\n\nSuccimer\tB-Chemical\nchelation\tO\nimproves\tO\nlearning\tO\n,\tO\nattention\tO\n,\tO\nand\tO\narousal\tO\nregulation\tO\nin\tO\nlead\tB-Chemical\n-\tO\nexposed\tO\nrats\tO\nbut\tO\nproduces\tO\nlasting\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\nin\tO\nthe\tO\nabsence\tO\nof\tO\nlead\tB-Chemical\nexposure\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThere\tO\nis\tO\ngrowing\tO\npressure\tO\nfor\tO\nclinicians\tO\nto\tO\nprescribe\tO\nchelation\tO\ntherapy\tO\nat\tO\nonly\tO\nslightly\tO\nelevated\tO\nblood\tO\nlead\tB-Chemical\nlevels\tO\n.\tO\n\nHowever\tO\n,\tO\nvery\tO\nfew\tO\nstudies\tO\nhave\tO\nevaluated\tO\nwhether\tO\nchelation\tO\nimproves\tO\ncognitive\tO\noutcomes\tO\nin\tO\nPb\tB-Chemical\n-\tO\nexposed\tO\nchildren\tO\n,\tO\nor\tO\nwhether\tO\nthese\tO\nagents\tO\nhave\tO\nadverse\tO\neffects\tO\nthat\tO\nmay\tO\naffect\tO\nbrain\tO\ndevelopment\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nPb\tB-Chemical\nexposure\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nanswer\tO\nthese\tO\nquestions\tO\n,\tO\nusing\tO\na\tO\nrodent\tO\nmodel\tO\nof\tO\nearly\tO\nchildhood\tO\nPb\tB-Chemical\nexposure\tO\nand\tO\ntreatment\tO\nwith\tO\nsuccimer\tB-Chemical\n,\tO\na\tO\nwidely\tO\nused\tO\nchelating\tO\nagent\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nPb\tB-Disease\npoisoning\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nPb\tB-Chemical\nexposure\tO\nproduced\tO\nlasting\tO\nimpairments\tB-Disease\nin\tI-Disease\nlearning\tI-Disease\n,\tI-Disease\nattention\tI-Disease\n,\tI-Disease\ninhibitory\tI-Disease\ncontrol\tI-Disease\n,\tI-Disease\nand\tI-Disease\narousal\tI-Disease\nregulation\tI-Disease\n,\tO\nparalleling\tO\nthe\tO\nareas\tO\nof\tO\ndysfunction\tO\nseen\tO\nin\tO\nPb\tB-Chemical\n-\tO\nexposed\tO\nchildren\tO\n.\tO\n\nSuccimer\tB-Chemical\ntreatment\tO\nof\tO\nthe\tO\nPb\tB-Chemical\n-\tO\nexposed\tO\nrats\tO\nsignificantly\tO\nimproved\tO\nlearning\tO\n,\tO\nattention\tO\n,\tO\nand\tO\narousal\tO\nregulation\tO\n,\tO\nalthough\tO\nthe\tO\nefficacy\tO\nof\tO\nthe\tO\ntreatment\tO\nvaried\tO\nas\tO\na\tO\nfunction\tO\nof\tO\nthe\tO\nPb\tB-Chemical\nexposure\tO\nlevel\tO\nand\tO\nthe\tO\nspecific\tO\nfunctional\tO\ndeficit\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nsuccimer\tB-Chemical\ntreatment\tO\nof\tO\nrats\tO\nnot\tO\npreviously\tO\nexposed\tO\nto\tO\nPb\tB-Chemical\nproduced\tO\nlasting\tO\nand\tO\npervasive\tO\ncognitive\tB-Disease\nand\tI-Disease\naffective\tI-Disease\ndysfunction\tI-Disease\ncomparable\tO\nin\tO\nmagnitude\tO\nto\tO\nthat\tO\nproduced\tO\nby\tO\nthe\tO\nhigher\tO\nPb\tB-Chemical\nexposure\tO\nregimen\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nare\tO\nthe\tO\nfirst\tO\ndata\tO\n,\tO\nto\tO\nour\tO\nknowledge\tO\n,\tO\nto\tO\nshow\tO\nthat\tO\ntreatment\tO\nwith\tO\nany\tO\nchelating\tO\nagent\tO\ncan\tO\nalleviate\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\ndue\tO\nto\tO\nPb\tB-Chemical\nexposure\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nit\tO\nmay\tO\nbe\tO\npossible\tO\nto\tO\nidentify\tO\na\tO\nsuccimer\tB-Chemical\ntreatment\tO\nprotocol\tO\nthat\tO\nimproves\tO\ncognitive\tO\noutcomes\tO\nin\tO\nPb\tB-Chemical\n-\tO\nexposed\tO\nchildren\tO\n.\tO\n\nHowever\tO\n,\tO\nthey\tO\nalso\tO\nsuggest\tO\nthat\tO\nsuccimer\tB-Chemical\ntreatment\tO\nshould\tO\nbe\tO\nstrongly\tO\ndiscouraged\tO\nfor\tO\nchildren\tO\nwho\tO\ndo\tO\nnot\tO\nhave\tO\nelevated\tO\ntissue\tO\nlevels\tO\nof\tO\nPb\tB-Chemical\nor\tO\nother\tO\nheavy\tO\nmetals\tO\n.\tO\n\nCaffeine\tB-Chemical\nchallenge\tO\ntest\tO\nin\tO\npanic\tB-Disease\ndisorder\tI-Disease\nand\tO\ndepression\tB-Disease\nwith\tO\npanic\tB-Disease\nattacks\tI-Disease\n.\tO\n\nOur\tO\naim\tO\nwas\tO\nto\tO\nobserve\tO\nif\tO\npatients\tO\nwith\tO\npanic\tB-Disease\ndisorder\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\nand\tO\npatients\tO\nwith\tO\nmajor\tB-Disease\ndepression\tI-Disease\nwith\tO\npanic\tB-Disease\nattacks\tI-Disease\n(\tO\nMDP\tB-Disease\n)\tO\n(\tO\nDiagnostic\tO\nand\tO\nStatistical\tO\nManual\tO\nof\tO\nMental\tB-Disease\nDisorders\tI-Disease\n,\tO\nFourth\tO\nEdition\tO\ncriteria\tO\n)\tO\nrespond\tO\nin\tO\na\tO\nsimilar\tO\nway\tO\nto\tO\nthe\tO\ninduction\tO\nof\tO\npanic\tB-Disease\nattacks\tI-Disease\nby\tO\nan\tO\noral\tO\ncaffeine\tB-Chemical\nchallenge\tO\ntest\tO\n.\tO\n\nWe\tO\nrandomly\tO\nselected\tO\n29\tO\npatients\tO\nwith\tO\nPD\tB-Disease\n,\tO\n27\tO\nwith\tO\nMDP\tB-Disease\n,\tO\n25\tO\nwith\tO\nmajor\tB-Disease\ndepression\tI-Disease\nwithout\tO\npanic\tB-Disease\nattacks\tI-Disease\n(\tO\nMD\tB-Disease\n)\tO\n,\tO\nand\tO\n28\tO\nhealthy\tO\nvolunteers\tO\n.\tO\n\nThe\tO\npatients\tO\nhad\tO\nno\tO\npsychotropic\tO\ndrug\tO\nfor\tO\nat\tO\nleast\tO\na\tO\n4\tO\n-\tO\nweek\tO\nperiod\tO\n.\tO\n\nIn\tO\na\tO\nrandomized\tO\ndouble\tO\n-\tO\nblind\tO\nexperiment\tO\nperformed\tO\nin\tO\n2\tO\noccasions\tO\n7\tO\ndays\tO\napart\tO\n,\tO\n480\tO\nmg\tO\ncaffeine\tB-Chemical\nand\tO\na\tO\ncaffeine\tB-Chemical\n-\tO\nfree\tO\n(\tO\nplacebo\tO\n)\tO\nsolution\tO\nwere\tO\nadministered\tO\nin\tO\na\tO\ncoffee\tO\nform\tO\nand\tO\nanxiety\tB-Disease\nscales\tO\nwere\tO\napplied\tO\nbefore\tO\nand\tO\nafter\tO\neach\tO\ntest\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n58\tO\n.\tO\n6\tO\n%\tO\n(\tO\nn\tO\n=\tO\n17\tO\n)\tO\nof\tO\npatients\tO\nwith\tO\nPD\tB-Disease\n,\tO\n44\tO\n.\tO\n4\tO\n%\tO\n(\tO\nn\tO\n=\tO\n12\tO\n)\tO\nof\tO\npatients\tO\nwith\tO\nMDP\tB-Disease\n,\tO\n12\tO\n.\tO\n0\tO\n%\tO\n(\tO\nn\tO\n=\tO\n3\tO\n)\tO\nof\tO\npatients\tO\nwith\tO\nMD\tB-Disease\n,\tO\nand\tO\n7\tO\n.\tO\n1\tO\n%\tO\n(\tO\nn\tO\n=\tO\n2\tO\n)\tO\nof\tO\ncontrol\tO\nsubjects\tO\nhad\tO\na\tO\npanic\tB-Disease\nattack\tI-Disease\nafter\tO\nthe\tO\n480\tO\n-\tO\nmg\tO\ncaffeine\tB-Chemical\nchallenge\tO\ntest\tO\n(\tO\nchi\tO\n(\tO\n2\tO\n)\tO\n(\tO\n3\tO\n)\tO\n=\tO\n16\tO\n.\tO\n22\tO\n,\tO\nP\tO\n=\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThe\tO\npatients\tO\nwith\tO\nPD\tB-Disease\nand\tO\nMDP\tB-Disease\nwere\tO\nmore\tO\nsensitive\tO\nto\tO\ncaffeine\tB-Chemical\nthan\tO\nwere\tO\npatients\tO\nwith\tO\nMD\tB-Disease\nand\tO\nhealthy\tO\nvolunteers\tO\n.\tO\n\nNo\tO\npanic\tB-Disease\nattack\tI-Disease\nwas\tO\nobserved\tO\nafter\tO\nthe\tO\ncaffeine\tB-Chemical\n-\tO\nfree\tO\nsolution\tO\nintake\tO\n.\tO\n\nThe\tO\npatients\tO\nwith\tO\nMD\tB-Disease\nhad\tO\na\tO\nlower\tO\nheart\tO\nrate\tO\nresponse\tO\nto\tO\nthe\tO\ntest\tO\nthan\tO\nall\tO\nthe\tO\nother\tO\ngroups\tO\n(\tO\n2\tO\n-\tO\nway\tO\nanalysis\tO\nof\tO\nvariance\tO\n,\tO\ngroup\tO\nby\tO\ntime\tO\ninteraction\tO\nwith\tO\nGreenhouse\tO\n-\tO\nGeisser\tO\ncorrection\tO\n:\tO\nF\tO\n(\tO\n3\tO\n,\tO\n762\tO\n)\tO\n=\tO\n2\tO\n.\tO\n85\tO\n,\tO\nP\tO\n=\tO\n.\tO\n026\tO\n)\tO\n.\tO\n\nOur\tO\ndata\tO\nsuggest\tO\nthat\tO\nthere\tO\nis\tO\nan\tO\nassociation\tO\nbetween\tO\npanic\tB-Disease\nattacks\tI-Disease\n,\tO\nno\tO\nmatter\tO\nif\tO\nassociated\tO\nwith\tO\nPD\tB-Disease\nor\tO\nMDP\tB-Disease\n,\tO\nand\tO\nhyperreactivity\tO\nto\tO\nan\tO\noral\tO\ncaffeine\tB-Chemical\nchallenge\tO\ntest\tO\n.\tO\n\nMitral\tO\nannuloplasty\tO\nas\tO\na\tO\nventricular\tO\nrestoration\tO\nmethod\tO\nfor\tO\nthe\tO\nfailing\tB-Disease\nleft\tI-Disease\nventricle\tI-Disease\n:\tO\na\tO\npilot\tO\nstudy\tO\n.\tO\n\nBACKGROUND\tO\nAND\tO\nAIM\tO\nOF\tO\nTHE\tO\nSTUDY\tO\n:\tO\nUndersized\tO\nmitral\tO\nannuloplasty\tO\n(\tO\nMAP\tO\n)\tO\nis\tO\neffective\tO\nin\tO\npatients\tO\nwith\tO\ndilated\tB-Disease\ncardiomyopathy\tI-Disease\nand\tO\nfunctional\tO\nmitral\tB-Disease\nregurgitation\tI-Disease\n(\tO\nMR\tB-Disease\n)\tO\nsince\tO\n,\tO\nas\tO\nwell\tO\nas\tO\naddressing\tO\nthe\tO\nMR\tB-Disease\n,\tO\nthe\tO\nMAP\tO\nmay\tO\nalso\tO\nreshape\tO\nthe\tO\ndilated\tO\nleft\tO\nventricular\tO\n(\tO\nLV\tO\n)\tO\nbase\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\ndirect\tO\nbenefits\tO\nof\tO\nthis\tO\npossible\tO\nreshaping\tO\non\tO\nLV\tO\nfunction\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nunderlying\tO\nMR\tB-Disease\nremain\tO\nincompletely\tO\nunderstood\tO\n.\tO\n\nThe\tO\nstudy\tO\naim\tO\nwas\tO\nto\tO\nidentify\tO\nthese\tO\nbenefits\tO\nin\tO\na\tO\ncanine\tO\nmodel\tO\nof\tO\nacute\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nSix\tO\ndogs\tO\nunderwent\tO\nMAP\tO\nwith\tO\na\tO\nprosthetic\tO\nband\tO\non\tO\nthe\tO\nposterior\tO\nmitral\tO\nannulus\tO\n,\tO\nusing\tO\nfour\tO\nmattress\tO\nsutures\tO\n.\tO\n\nThe\tO\nsutures\tO\nwere\tO\npassed\tO\nindividually\tO\nthrough\tO\nfour\tO\ntourniquets\tO\nand\tO\nexteriorized\tO\nuntied\tO\nvia\tO\nthe\tO\nleft\tO\natriotomy\tO\n.\tO\n\nSonomicrometry\tO\ncrystals\tO\nwere\tO\nimplanted\tO\naround\tO\nthe\tO\nmitral\tO\nannulus\tO\nand\tO\nleft\tO\nventricle\tO\nto\tO\nmeasure\tO\ngeometry\tO\nand\tO\nregional\tO\nfunction\tO\n.\tO\n\nAcute\tO\nheart\tB-Disease\nfailure\tI-Disease\nwas\tO\ninduced\tO\nby\tO\npropranolol\tB-Chemical\nand\tO\nvolume\tO\nloading\tO\nafter\tO\nweaning\tO\nfrom\tO\ncardiopulmonary\tO\nbypass\tO\n;\tO\nan\tO\nabsence\tO\nof\tO\nMR\tB-Disease\nwas\tO\nconfirmed\tO\nby\tO\nechocardiography\tO\n.\tO\n\nMAP\tO\nwas\tO\naccomplished\tO\nby\tO\ncinching\tO\nthe\tO\ntourniquets\tO\n.\tO\n\nData\tO\nwere\tO\nacquired\tO\nat\tO\nbaseline\tO\n,\tO\nafter\tO\ninduction\tO\nof\tO\nacute\tO\nheart\tB-Disease\nfailure\tI-Disease\n,\tO\nand\tO\nafter\tO\nMAP\tO\n.\tO\n\nRESULTS\tO\n:\tO\nMAP\tO\ndecreased\tO\nmitral\tO\nannular\tO\ndimensions\tO\nin\tO\nboth\tO\ncommissure\tO\n-\tO\ncommissure\tO\nand\tO\nseptal\tO\n-\tO\nlateral\tO\ndirections\tO\n.\tO\n\nConcomitantly\tO\n,\tO\nthe\tO\ndiastolic\tO\ndiameter\tO\nof\tO\nthe\tO\nLV\tO\nbase\tO\nand\tO\nLV\tO\nsphericity\tO\ndecreased\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nimproved\tO\n)\tO\nfrom\tO\n37\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n9\tO\n.\tO\n3\tO\nto\tO\n35\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n10\tO\nmm\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n063\tO\n)\tO\n,\tO\nand\tO\nfrom\tO\n67\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n18\tO\n.\tO\n6\tO\n%\tO\nto\tO\n65\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n18\tO\n.\tO\n9\tO\n%\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n016\tO\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nDecreases\tO\nwere\tO\nevident\tO\nin\tO\nboth\tO\nLV\tO\nend\tO\n-\tO\ndiastolic\tO\npressure\tO\n(\tO\nfrom\tO\n17\tO\n+\tO\n/\tO\n-\tO\n7\tO\nto\tO\n15\tO\n+\tO\n/\tO\n-\tO\n6\tO\nmmHg\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n0480\tO\nand\tO\nTau\tO\n(\tO\nfrom\tO\n48\tO\n+\tO\n/\tO\n-\tO\n8\tO\nto\tO\n45\tO\n+\tO\n/\tO\n-\tO\n8\tO\nms\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nwhile\tO\nfractional\tO\nshortening\tO\nat\tO\nthe\tO\nLV\tO\nbase\tO\nincreased\tO\nfrom\tO\n7\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n5\tO\n%\tO\nto\tO\n9\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n5\tO\n%\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n045\tO\n)\tO\n.\tO\n\nAfter\tO\nMAP\tO\n,\tO\nincreases\tO\nwere\tO\nidentified\tO\nin\tO\nboth\tO\ncardiac\tO\noutput\tO\n(\tO\nfrom\tO\n1\tO\n.\tO\n54\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n57\tO\nto\tO\n1\tO\n.\tO\n65\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n57\tO\n1\tO\n/\tO\nmin\tO\n)\tO\nand\tO\nEmax\tO\n(\tO\nfrom\tO\n1\tO\n.\tO\n86\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n9\tO\nto\tO\n2\tO\n.\tO\n41\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n31\tO\nmmHg\tO\n/\tO\nml\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\ndata\tO\nacquired\tO\nsuggest\tO\nthat\tO\nisolated\tO\nMAP\tO\nmay\tO\nhave\tO\ncertain\tO\nbenefits\tO\non\tO\nLV\tO\ndimension\tO\n/\tO\nfunction\tO\nin\tO\nacute\tO\nheart\tB-Disease\nfailure\tI-Disease\n,\tO\neven\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nMR\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nfurther\tO\ninvestigations\tO\nare\tO\nwarranted\tO\nin\tO\na\tO\nmodel\tO\nof\tO\nchronic\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nPiperacillin\tB-Chemical\n/\tI-Chemical\ntazobactam\tI-Chemical\n-\tO\ninduced\tO\nseizure\tB-Disease\nrapidly\tO\nreversed\tO\nby\tO\nhigh\tO\nflux\tO\nhemodialysis\tO\nin\tO\na\tO\npatient\tO\non\tO\nperitoneal\tO\ndialysis\tO\n.\tO\n\nDespite\tO\npopular\tO\nuse\tO\nof\tO\npiperacillin\tB-Chemical\n,\tO\nthe\tO\ndire\tO\nneurotoxicity\tB-Disease\nassociated\tO\nwith\tO\npiperacillin\tB-Chemical\nstill\tO\ngoes\tO\nunrecognized\tO\n,\tO\nleading\tO\nto\tO\na\tO\ndelay\tO\nin\tO\nappropriate\tO\nmanagement\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\n57\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\nreceiving\tO\ncontinuous\tO\nambulatory\tO\nperitoneal\tO\ndialysis\tO\n(\tO\nCAPD\tO\n)\tO\n,\tO\nwho\tO\ndeveloped\tO\nslurred\tO\nspeech\tO\n,\tO\ntremor\tB-Disease\n,\tO\nbizarre\tO\nbehavior\tO\n,\tO\nprogressive\tO\nmental\tO\nconfusion\tB-Disease\n,\tO\nand\tO\n2\tO\nepisodes\tO\nof\tO\ngeneralized\tO\ntonic\tB-Disease\n-\tI-Disease\nclonic\tI-Disease\nseizure\tI-Disease\n(\tO\nGTCS\tB-Disease\n)\tO\nafter\tO\n5\tO\ndoses\tO\nof\tO\npiperacillin\tB-Chemical\n/\tI-Chemical\ntazobactam\tI-Chemical\n(\tO\n2\tO\ng\tO\n/\tO\n250\tO\nmg\tO\n)\tO\nwere\tO\ngiven\tO\nfor\tO\nbronchiectasis\tB-Disease\nwith\tO\nsecondary\tB-Disease\ninfection\tI-Disease\n.\tO\n\nThe\tO\nlaboratory\tO\ndata\tO\nrevealed\tO\nnormal\tO\nplasma\tO\nelectrolyte\tO\nand\tO\nammonia\tB-Chemical\nlevels\tO\nbut\tO\nleukocytosis\tB-Disease\n.\tO\n\nNeurologic\tO\nexaminations\tO\nshowed\tO\ndysarthria\tB-Disease\nand\tO\nbilateral\tO\nBabinski\tO\nsign\tO\n.\tO\n\nComputed\tO\ntomography\tO\nof\tO\nbrain\tO\nand\tO\nelectroencephalogram\tO\nwere\tO\nunremarkable\tO\n.\tO\n\nDespite\tO\nthe\tO\nuse\tO\nof\tO\nantiepileptic\tO\nagents\tO\n,\tO\nanother\tO\nGTCS\tB-Disease\nepisode\tO\nrecurred\tO\nafter\tO\nthe\tO\nsixth\tO\ndose\tO\nof\tO\npiperacillin\tB-Chemical\n/\tI-Chemical\ntazobactam\tI-Chemical\n.\tO\n\nBrain\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\ndid\tO\nnot\tO\ndemonstrate\tO\nacute\tO\ninfarction\tB-Disease\nand\tO\norganic\tB-Disease\nbrain\tI-Disease\nlesions\tI-Disease\n.\tO\n\nInitiation\tO\nof\tO\nhigh\tO\n-\tO\nflux\tO\nhemodialysis\tO\nrapidly\tO\nreversed\tO\nthe\tO\nneurologic\tO\nsymptoms\tO\nwithin\tO\n4\tO\nhours\tO\n.\tO\n\nPiperacillin\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\nshould\tO\nbe\tO\nconsidered\tO\nin\tO\nany\tO\nuremic\tB-Disease\npatients\tO\nwith\tO\nunexplained\tO\nneurological\tO\nmanifestations\tO\n.\tO\n\nCAPD\tO\nis\tO\ninefficient\tO\nin\tO\nremoving\tO\npiperacillin\tB-Chemical\n,\tO\nwhereas\tO\nhemodialysis\tO\ncan\tO\nrapidly\tO\nterminate\tO\nthe\tO\npiperacillin\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\n.\tO\n\nFrequency\tO\nof\tO\ntransient\tO\nipsilateral\tO\nvocal\tB-Disease\ncord\tI-Disease\nparalysis\tI-Disease\nin\tO\npatients\tO\nundergoing\tO\ncarotid\tO\nendarterectomy\tO\nunder\tO\nlocal\tO\nanesthesia\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nEspecially\tO\nbecause\tO\nof\tO\nimprovements\tO\nin\tO\nclinical\tO\nneurologic\tO\nmonitoring\tO\n,\tO\ncarotid\tO\nendarterectomy\tO\ndone\tO\nunder\tO\nlocal\tO\nanesthesia\tO\nhas\tO\nbecome\tO\nthe\tO\ntechnique\tO\nof\tO\nchoice\tO\nin\tO\nseveral\tO\ncenters\tO\n.\tO\n\nTemporary\tO\nipsilateral\tO\nvocal\tB-Disease\nnerve\tI-Disease\npalsies\tI-Disease\ndue\tO\nto\tO\nlocal\tO\nanesthetics\tO\nhave\tO\nbeen\tO\ndescribed\tO\n,\tO\nhowever\tO\n.\tO\n\nSuch\tO\ncomplications\tO\nare\tO\nmost\tO\nimportant\tO\nin\tO\nsituations\tO\nwhere\tO\nthere\tO\nis\tO\na\tO\npre\tO\n-\tO\nexisting\tO\ncontralateral\tO\nparalysis\tB-Disease\n.\tO\n\nWe\tO\ntherefore\tO\nexamined\tO\nthe\tO\neffect\tO\nof\tO\nlocal\tO\nanesthesia\tO\non\tO\nvocal\tO\ncord\tO\nfunction\tO\nto\tO\nbetter\tO\nunderstand\tO\nits\tO\npossible\tO\nconsequences\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nprospective\tO\nstudy\tO\nincluded\tO\n28\tO\npatients\tO\nundergoing\tO\ncarotid\tO\nendarterectomy\tO\nunder\tO\nlocal\tO\nanesthesia\tO\n.\tO\n\nVocal\tO\ncord\tO\nfunction\tO\nwas\tO\nevaluated\tO\nbefore\tO\n,\tO\nduring\tO\n,\tO\nand\tO\nafter\tO\nsurgery\tO\n(\tO\npostoperative\tO\nday\tO\n1\tO\n)\tO\nusing\tO\nflexible\tO\nlaryngoscopy\tO\n.\tO\n\nAnesthesia\tO\nwas\tO\nperformed\tO\nby\tO\ninjecting\tO\n20\tO\nto\tO\n40\tO\nmL\tO\nof\tO\na\tO\nmixture\tO\nof\tO\nlong\tO\n-\tO\nacting\tO\n(\tO\nropivacaine\tB-Chemical\n)\tO\nand\tO\nshort\tO\n-\tO\nacting\tO\n(\tO\nprilocaine\tB-Chemical\n)\tO\nanesthetic\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\npatients\tO\nhad\tO\nnormal\tO\nvocal\tO\ncord\tO\nfunction\tO\npreoperatively\tO\n.\tO\n\nTwelve\tO\npatients\tO\n(\tO\n43\tO\n%\tO\n)\tO\nwere\tO\nfound\tO\nto\tO\nhave\tO\nintraoperative\tO\nipsilateral\tO\nvocal\tB-Disease\ncord\tI-Disease\nparalysis\tI-Disease\n.\tO\n\nIt\tO\nresolved\tO\nin\tO\nall\tO\ncases\tO\n<\tO\nor\tO\n=\tO\n24\tO\nhours\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nsignificant\tO\ndifferences\tO\nin\tO\noperating\tO\ntime\tO\nor\tO\nvolume\tO\nor\tO\nfrequency\tO\nof\tO\nanesthetic\tO\nadministration\tO\nin\tO\npatients\tO\nwith\tO\ntemporary\tO\nvocal\tB-Disease\ncord\tI-Disease\nparalysis\tI-Disease\ncompared\tO\nwith\tO\nthose\tO\nwithout\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nLocal\tO\nanesthesia\tO\nled\tO\nto\tO\ntemporary\tO\nipsilateral\tO\nvocal\tB-Disease\ncord\tI-Disease\nparalysis\tI-Disease\nin\tO\nalmost\tO\nhalf\tO\nof\tO\nthese\tO\npatients\tO\n.\tO\n\nBecause\tO\npre\tO\n-\tO\nexisting\tO\nparalysis\tB-Disease\nis\tO\nof\tO\na\tO\nrelevant\tO\nfrequency\tO\n(\tO\nup\tO\nto\tO\n3\tO\n%\tO\n)\tO\n,\tO\na\tO\npreoperative\tO\nevaluation\tO\nof\tO\nvocal\tO\ncord\tO\nfunction\tO\nbefore\tO\ncarotid\tO\nendarterectomy\tO\nunder\tO\nlocal\tO\nanesthesia\tO\nis\tO\nrecommended\tO\nto\tO\navoid\tO\nintraoperative\tO\nbilateral\tO\nparalysis\tB-Disease\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\npreoperative\tO\ncontralateral\tO\nvocal\tB-Disease\ncord\tI-Disease\nparalysis\tI-Disease\n,\tO\nsurgery\tO\nunder\tO\ngeneral\tO\nanesthesia\tO\nshould\tO\nbe\tO\nconsidered\tO\n.\tO\n\nImpaired\tB-Disease\nfear\tI-Disease\nrecognition\tI-Disease\nin\tO\nregular\tO\nrecreational\tO\ncocaine\tB-Chemical\nusers\tO\n.\tO\n\nINTRODUCTION\tO\n:\tO\nThe\tO\nability\tO\nto\tO\nread\tO\nfacial\tO\nexpressions\tO\nis\tO\nessential\tO\nfor\tO\nnormal\tO\nhuman\tO\nsocial\tO\ninteraction\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\nconduct\tO\nthe\tO\nfirst\tO\ninvestigation\tO\nof\tO\nfacial\tO\nexpression\tO\nrecognition\tO\nperformance\tO\nin\tO\nrecreational\tO\ncocaine\tB-Chemical\nusers\tO\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nThree\tO\ngroups\tO\n,\tO\ncomprised\tO\nof\tO\n21\tO\ncocaine\tB-Chemical\nnaive\tO\nparticipants\tO\n(\tO\nCN\tO\n)\tO\n,\tO\n30\tO\noccasional\tO\ncocaine\tB-Chemical\n(\tO\nOC\tO\n)\tO\n,\tO\nand\tO\n48\tO\nregular\tO\nrecreational\tO\ncocaine\tB-Chemical\n(\tO\nRC\tO\n)\tO\nusers\tO\n,\tO\nwere\tO\ncompared\tO\n.\tO\n\nAn\tO\nemotional\tO\nfacial\tO\nexpression\tO\n(\tO\nEFE\tO\n)\tO\ntask\tO\nconsisting\tO\nof\tO\na\tO\nmale\tO\nand\tO\nfemale\tO\nface\tO\nexpressing\tO\nsix\tO\nbasic\tO\nemotions\tO\n(\tO\nhappiness\tO\n,\tO\nsurprise\tO\n,\tO\nsadness\tO\n,\tO\nanger\tO\n,\tO\nfear\tO\n,\tO\nand\tO\ndisgust\tO\n)\tO\nwas\tO\nadministered\tO\n.\tO\n\nMean\tO\npercent\tO\naccuracy\tO\nand\tO\nlatencies\tO\nfor\tO\ncorrect\tO\nresponses\tO\nacross\tO\neight\tO\npresentations\tO\nof\tO\neach\tO\nbasic\tO\nemotion\tO\nwere\tO\nderived\tO\n.\tO\n\nParticipants\tO\nwere\tO\nalso\tO\nassessed\tO\nwith\tO\nthe\tO\n\"\tO\nEyes\tO\ntask\tO\n\"\tO\nto\tO\ninvestigate\tO\ntheir\tO\nability\tO\nto\tO\nrecognize\tO\nmore\tO\ncomplex\tO\nemotional\tO\nstates\tO\nand\tO\nthe\tO\nSymptom\tO\nCheckList\tO\n-\tO\n90\tO\n-\tO\nRevised\tO\nto\tO\nmeasure\tO\npsychopathology\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThere\tO\nwere\tO\nno\tO\ngroup\tO\ndifferences\tO\nin\tO\npsychopathology\tO\nor\tO\n\"\tO\neyes\tO\ntask\tO\n\"\tO\nperformance\tO\n,\tO\nbut\tO\nthe\tO\nRC\tO\ngroup\tO\n,\tO\nwho\tO\notherwise\tO\nhad\tO\nsimilar\tO\nillicit\tO\nsubstance\tO\nuse\tO\nhistories\tO\nto\tO\nthe\tO\nOC\tO\ngroup\tO\n,\tO\nexhibited\tO\nimpaired\tB-Disease\nfear\tI-Disease\nrecognition\tI-Disease\naccuracy\tO\ncompared\tO\nto\tO\nthe\tO\nOC\tO\nand\tO\nCN\tO\ngroups\tO\n.\tO\n\nThe\tO\nRC\tO\ngroup\tO\nalso\tO\ncorrectly\tO\nidentified\tO\nanger\tO\n,\tO\nfear\tO\n,\tO\nhappiness\tO\n,\tO\nand\tO\nsurprise\tO\n,\tO\nmore\tO\nslowly\tO\nthan\tO\nCN\tO\n,\tO\nbut\tO\nnot\tO\nOC\tO\nparticipants\tO\n.\tO\n\nThe\tO\nOC\tO\ngroup\tO\nwas\tO\nslower\tO\nthan\tO\nCN\tO\nwhen\tO\ncorrectly\tO\nidentifying\tO\ndisgust\tO\n.\tO\n\nThe\tO\nselective\tO\ndeficit\tB-Disease\nin\tI-Disease\nfear\tI-Disease\nrecognition\tI-Disease\naccuracy\tO\nmanifested\tO\nby\tO\nthe\tO\nRC\tO\ngroup\tO\ncannot\tO\nbe\tO\nexplained\tO\nby\tO\nthe\tO\nsubacute\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\n,\tO\nor\tO\necstasy\tB-Chemical\n,\tO\nbecause\tO\nrecent\tO\nand\tO\nless\tO\nrecent\tO\nusers\tO\nof\tO\nthese\tO\ndrugs\tO\nwithin\tO\nthis\tO\ngroup\tO\nwere\tO\nsimilarly\tO\nimpaired\tO\n.\tO\n\nPossible\tO\nparallels\tO\nbetween\tO\nRC\tO\nusers\tO\nand\tO\npsychopaths\tB-Disease\nwith\tO\nrespect\tO\nto\tO\nimpaired\tB-Disease\nfear\tI-Disease\nrecognition\tI-Disease\n,\tO\namygdala\tB-Disease\ndysfunction\tI-Disease\n,\tO\nand\tO\netiology\tO\nare\tO\ndiscussed\tO\n.\tO\n\nDamage\tB-Disease\nof\tI-Disease\nsubstantia\tI-Disease\nnigra\tI-Disease\npars\tI-Disease\nreticulata\tI-Disease\nduring\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nin\tO\nthe\tO\nrat\tO\n:\tO\nimmunohistochemical\tO\nstudy\tO\nof\tO\nneurons\tO\n,\tO\nastrocytes\tO\nand\tO\nserum\tO\n-\tO\nprotein\tO\nextravasation\tO\n.\tO\n\nThe\tO\nsubstantia\tO\nnigra\tO\nhas\tO\na\tO\ngating\tO\nfunction\tO\ncontrolling\tO\nthe\tO\nspread\tO\nof\tO\nepileptic\tB-Disease\nseizure\tI-Disease\nactivity\tO\n.\tO\n\nAdditionally\tO\n,\tO\nin\tO\nmodels\tO\nof\tO\nprolonged\tB-Disease\nstatus\tI-Disease\nepilepticus\tI-Disease\nthe\tO\npars\tO\nreticulata\tO\nof\tO\nsubstantia\tO\nnigra\tO\n(\tO\nSNR\tO\n)\tO\nsuffers\tO\nfrom\tO\na\tO\nmassive\tO\nlesion\tO\nwhich\tO\nmay\tO\narise\tO\nfrom\tO\na\tO\nmassive\tO\nmetabolic\tB-Disease\nderangement\tI-Disease\nand\tO\nhyperexcitation\tO\ndeveloping\tO\nin\tO\nthe\tO\nactivated\tO\nSNR\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nwas\tO\ninduced\tO\nby\tO\nsystemic\tO\ninjection\tO\nof\tO\npilocarpine\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nneuropathology\tO\nof\tO\nSNR\tO\nwas\tO\ninvestigated\tO\nusing\tO\nimmunohistochemical\tO\ntechniques\tO\nwith\tO\nthe\tO\nmajor\tO\nemphasis\tO\non\tO\nthe\tO\ntime\tO\n-\tO\ncourse\tO\nof\tO\nchanges\tO\nin\tO\nneurons\tO\nand\tO\nastrocytes\tO\n.\tO\n\nAnimals\tO\nsurviving\tO\n20\tO\n,\tO\n30\tO\n,\tO\n40\tO\n,\tO\n60\tO\nmin\tO\n,\tO\n2\tO\n,\tO\n3\tO\n,\tO\n6\tO\nhours\tO\n,\tO\n1\tO\n,\tO\n2\tO\n,\tO\nand\tO\n3\tO\ndays\tO\nafter\tO\ninduction\tO\nof\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nwere\tO\nperfusion\tO\n-\tO\nfixed\tO\n,\tO\nand\tO\nbrains\tO\nprocessed\tO\nfor\tO\nimmunohistochemical\tO\nstaining\tO\nof\tO\nSNR\tO\n.\tO\n\nNissl\tO\n-\tO\nstaining\tO\nand\tO\nantibodies\tO\nagainst\tO\nthe\tO\nneuron\tO\n-\tO\nspecific\tO\ncalcium\tB-Chemical\n-\tO\nbinding\tO\nprotein\tO\n,\tO\nparvalbumin\tO\n,\tO\nserved\tO\nto\tO\ndetect\tO\nneuronal\tB-Disease\ndamage\tI-Disease\nin\tO\nSNR\tO\n.\tO\n\nAntibodies\tO\nagainst\tO\nthe\tO\nastroglia\tO\n-\tO\nspecific\tO\ncytoskeletal\tO\nprotein\tO\n,\tO\nglial\tO\nfibrillary\tO\nacidic\tO\nprotein\tO\n(\tO\nGFAP\tO\n)\tO\n,\tO\nand\tO\nagainst\tO\nthe\tO\nglial\tO\ncalcium\tB-Chemical\n-\tO\nbinding\tO\nprotein\tO\n,\tO\nS\tO\n-\tO\n100\tO\nprotein\tO\n,\tO\nwere\tO\nused\tO\nto\tO\nassess\tO\nthe\tO\nstatus\tO\nof\tO\nastrocytes\tO\n.\tO\n\nImmunohistochemical\tO\nstaining\tO\nfor\tO\nserum\tO\n-\tO\nalbumin\tO\nand\tO\nimmunoglobulins\tO\nin\tO\nbrain\tO\ntissue\tO\nwas\tO\ntaken\tO\nas\tO\nindicator\tO\nof\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\ndisturbances\tO\nand\tO\nvasogenic\tB-Disease\nedema\tI-Disease\nformation\tO\n.\tO\n\nImmunohistochemical\tO\nstaining\tO\nindicated\tO\nloss\tO\nof\tO\nGFAP\tO\n-\tO\nstaining\tO\nalready\tO\nat\tO\n30\tO\nmin\tO\nafter\tO\ninduction\tO\nof\tO\nseizures\tB-Disease\nin\tO\nan\tO\noval\tO\nfocus\tO\nsituated\tO\nin\tO\nthe\tO\ncenter\tO\nof\tO\nSNR\tO\nwhile\tO\nsparing\tO\nmedial\tO\nand\tO\nlateral\tO\naspects\tO\n.\tO\n\nAt\tO\n1\tO\nh\tO\nthere\tO\nwas\tO\nadditional\tO\nvacuolation\tO\nin\tO\nS\tO\n-\tO\n100\tO\nprotein\tO\nstaining\tO\n.\tO\n\nBy\tO\n2\tO\nhours\tO\n,\tO\nparvalbumin\tO\n-\tO\nstaining\tO\nchanged\tO\nin\tO\nthe\tO\ncentral\tO\nSNR\tO\nindicating\tO\nneuronal\tB-Disease\ndamage\tI-Disease\n,\tO\nand\tO\nNissl\tO\n-\tO\nstaining\tO\nvisualized\tO\nsome\tO\nneuronal\tO\ndistortion\tO\n.\tO\n\nStaining\tO\nfor\tO\nserum\tO\n-\tO\nproteins\tO\noccurred\tO\nin\tO\na\tO\npatchy\tO\nmanner\tO\nthroughout\tO\nthe\tO\nforebrain\tO\nduring\tO\nthe\tO\nfirst\tO\nhours\tO\n.\tO\n\nBy\tO\n6\tO\nh\tO\n,\tO\nvasogenic\tB-Disease\nedema\tI-Disease\ncovered\tO\nthe\tO\nlesioned\tB-Disease\nSNR\tI-Disease\n.\tO\n\nBy\tO\n24\tO\nh\tO\n,\tO\nglial\tO\nand\tO\nneuronal\tO\nmarkers\tO\nindicated\tO\na\tO\nmassive\tO\nlesion\tO\nin\tO\nthe\tO\ncenter\tO\nof\tO\nSNR\tO\n.\tO\n\nBy\tO\n48\tO\n-\tO\n72\tO\nh\tO\n,\tO\nastrocytes\tO\nsurrounding\tO\nthe\tO\nlesion\tO\nincreased\tO\nin\tO\nsize\tO\n,\tO\nand\tO\npolymorphic\tO\nphagocytotic\tO\ncells\tO\ninvaded\tO\nthe\tO\ndamaged\tO\narea\tO\n.\tO\n\nIn\tO\na\tO\nfurther\tO\ngroup\tO\nof\tO\nanimals\tO\nsurviving\tO\n1\tO\nto\tO\n5\tO\ndays\tO\n,\tO\nconventional\tO\nparaffin\tO\n-\tO\nsections\tO\nconfirmed\tO\nthe\tO\nneuronal\tO\nand\tO\nglial\tO\ndamage\tB-Disease\nof\tI-Disease\nSNR\tI-Disease\n.\tO\n\nAdditional\tO\npathology\tO\nof\tO\nsimilar\tO\nquality\tO\nwas\tO\nfound\tO\nin\tO\nthe\tO\nglobus\tO\npallidus\tO\n.\tO\n\nSince\tO\nastrocytes\tO\nwere\tO\nalways\tO\ndamaged\tO\nin\tO\nparallel\tO\nwith\tO\nneurons\tO\nin\tO\nSNR\tO\nit\tO\nis\tO\nproposed\tO\nthat\tO\nthe\tO\nanatomical\tO\nand\tO\nfunctional\tO\ninterrelationship\tO\nbetween\tO\nneurons\tO\nand\tO\nastrocytes\tO\nis\tO\nparticularly\tO\ntight\tO\nin\tO\nSNR\tO\n.\tO\n\nBoth\tO\ncell\tO\nelements\tO\nmay\tO\nsuffer\tO\nin\tO\ncommon\tO\nfrom\tO\nmetabolic\tO\ndisturbance\tO\nand\tO\nneurotransmitter\tB-Disease\ndysfunction\tI-Disease\nas\tO\noccur\tO\nduring\tO\nmassive\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n.\tO\n\nNeuroprotective\tO\neffects\tO\nof\tO\nmelatonin\tB-Chemical\nupon\tO\nthe\tO\noffspring\tO\ncerebellar\tO\ncortex\tO\nin\tO\nthe\tO\nrat\tO\nmodel\tO\nof\tO\nBCNU\tB-Chemical\n-\tO\ninduced\tO\ncortical\tB-Disease\ndysplasia\tI-Disease\n.\tO\n\nCortical\tB-Disease\ndysplasia\tI-Disease\nis\tO\na\tO\nmalformation\tO\ncharacterized\tO\nby\tO\ndefects\tO\nin\tO\nproliferation\tO\n,\tO\nmigration\tO\nand\tO\nmaturation\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\nthe\tO\nalterations\tO\nin\tO\noffspring\tO\nrat\tO\ncerebellum\tO\ninduced\tO\nby\tO\nmaternal\tO\nexposure\tO\nto\tO\ncarmustine\tB-Chemical\n-\tO\n[\tO\n1\tB-Chemical\n,\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nbis\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nchloroethyl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nnitrosoure\tI-Chemical\n]\tO\n(\tO\nBCNU\tB-Chemical\n)\tO\nand\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\nexogenous\tO\nmelatonin\tB-Chemical\nupon\tO\ncerebellar\tO\nBCNU\tB-Chemical\n-\tO\ninduced\tO\ncortical\tB-Disease\ndysplasia\tI-Disease\n,\tO\nusing\tO\nhistological\tO\nand\tO\nbiochemical\tO\nanalyses\tO\n.\tO\n\nPregnant\tO\nWistar\tO\nrats\tO\nwere\tO\nassigned\tO\nto\tO\nfive\tO\ngroups\tO\n:\tO\nintact\tO\n-\tO\ncontrol\tO\n,\tO\nsaline\tO\n-\tO\ncontrol\tO\n,\tO\nmelatonin\tB-Chemical\n-\tO\ntreated\tO\n,\tO\nBCNU\tB-Chemical\n-\tO\nexposed\tO\nand\tO\nBCNU\tB-Chemical\n-\tO\nexposed\tO\nplus\tO\nmelatonin\tB-Chemical\n.\tO\n\nRats\tO\nwere\tO\nexposed\tO\nto\tO\nBCNU\tB-Chemical\non\tO\nembryonic\tO\nday\tO\n15\tO\nand\tO\nmelatonin\tB-Chemical\nwas\tO\ngiven\tO\nuntil\tO\ndelivery\tO\n.\tO\n\nImmuno\tO\n/\tO\nhistochemistry\tO\nand\tO\nelectron\tO\nmicroscopy\tO\nwere\tO\ncarried\tO\nout\tO\non\tO\nthe\tO\noffspring\tO\ncerebellum\tO\n,\tO\nand\tO\nlevels\tO\nof\tO\nmalondialdehyde\tB-Chemical\nand\tO\nsuperoxide\tB-Chemical\ndismutase\tO\nwere\tO\ndetermined\tO\n.\tO\n\nHistopathologically\tO\n,\tO\ntypical\tO\nfindings\tO\nwere\tO\nobserved\tO\nin\tO\nthe\tO\ncerebella\tO\nfrom\tO\nthe\tO\ncontrol\tO\ngroups\tO\n,\tO\nbut\tO\nthe\tO\nfindings\tO\nconsistent\tO\nwith\tO\nearly\tO\nembryonic\tO\ndevelopment\tO\nwere\tO\nnoted\tO\nin\tO\nBCNU\tB-Chemical\n-\tO\nexposed\tO\ncortical\tB-Disease\ndysplasia\tI-Disease\ngroup\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nmarked\tO\nincrease\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nTUNEL\tO\npositive\tO\ncells\tO\nand\tO\nnestin\tO\npositive\tO\ncells\tO\nin\tO\nBCNU\tB-Chemical\n-\tO\nexposed\tO\ngroup\tO\n,\tO\nbut\tO\na\tO\ndecreased\tO\nimmunoreactivity\tO\nto\tO\nglial\tO\nfibrillary\tO\nacidic\tO\nprotein\tO\n,\tO\nsynaptophysin\tO\nand\tO\ntransforming\tO\ngrowth\tO\nfactor\tO\nbeta1\tO\nwas\tO\nobserved\tO\n,\tO\nindicating\tO\na\tO\ndelayed\tO\nmaturation\tO\n,\tO\nand\tO\nmelatonin\tB-Chemical\nsignificantly\tO\nreversed\tO\nthese\tO\nchanges\tO\n.\tO\n\nMalondialdehyde\tB-Chemical\nlevel\tO\nin\tO\nBCNU\tB-Chemical\n-\tO\nexposed\tO\ngroup\tO\nwas\tO\nhigher\tO\nthan\tO\nthose\tO\nin\tO\ncontrol\tO\ngroups\tO\nand\tO\nmelatonin\tB-Chemical\ndecreased\tO\nmalondialdehyde\tB-Chemical\nlevels\tO\nin\tO\nBCNU\tB-Chemical\ngroup\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nwhile\tO\nthere\tO\nwere\tO\nno\tO\nsignificant\tO\ndifferences\tO\nin\tO\nthe\tO\nsuperoxide\tB-Chemical\ndismutase\tO\nlevels\tO\nbetween\tO\nthese\tO\ngroups\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\nexposure\tO\nof\tO\nanimals\tO\nto\tO\nBCNU\tB-Chemical\nduring\tO\npregnancy\tO\nleads\tO\nto\tO\ndelayed\tO\nmaturation\tO\nof\tO\noffspring\tO\ncerebellum\tO\nand\tO\nmelatonin\tB-Chemical\nprotects\tO\nthe\tO\ncerebellum\tO\nagainst\tO\nthe\tO\neffects\tO\nof\tO\nBCNU\tB-Chemical\n.\tO\n\nReduced\tO\ncardiotoxicity\tB-Disease\nof\tO\ndoxorubicin\tB-Chemical\ngiven\tO\nin\tO\nthe\tO\nform\tO\nof\tO\nN\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nhydroxypropyl\tI-Chemical\n)\tI-Chemical\nmethacrylamide\tI-Chemical\nconjugates\tO\n:\tO\nand\tO\nexperimental\tO\nstudy\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nA\tO\nrat\tO\nmodel\tO\nwas\tO\nused\tO\nto\tO\nevaluate\tO\nthe\tO\ngeneral\tO\nacute\tO\ntoxicity\tB-Disease\nand\tO\nthe\tO\nlate\tO\ncardiotoxicity\tB-Disease\nof\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\ngiven\tO\neither\tO\nas\tO\nfree\tO\ndrug\tO\nor\tO\nin\tO\nthe\tO\nform\tO\nof\tO\nthree\tO\nN\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nhydroxypropyl\tI-Chemical\n)\tI-Chemical\nmethacrylamide\tI-Chemical\n(\tO\nHPMA\tB-Chemical\n)\tO\ncopolymer\tO\nconjugates\tO\n.\tO\n\nIn\tO\nthese\tO\nHPMA\tB-Chemical\ncopolymers\tO\n,\tO\nDOX\tB-Chemical\nwas\tO\ncovalently\tO\nbound\tO\nvia\tO\npeptide\tO\nlinkages\tO\nthat\tO\nwere\tO\neither\tO\nnon\tO\n-\tO\nbiodegradable\tO\n(\tO\nGly\tO\n-\tO\nGly\tO\n)\tO\nor\tO\ndegradable\tO\nby\tO\nlysosomal\tO\nproteinases\tO\n(\tO\nGly\tB-Chemical\n-\tI-Chemical\nPhe\tI-Chemical\n-\tI-Chemical\nLeu\tI-Chemical\n-\tI-Chemical\nGly\tI-Chemical\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\none\tO\nbiodegradable\tO\nconjugate\tO\ncontaining\tO\ngalactosamine\tB-Chemical\nwas\tO\nused\tO\n;\tO\nthis\tO\nresidue\tO\nwas\tO\ntargeted\tO\nto\tO\nthe\tO\nliver\tO\n.\tO\n\nOver\tO\nthe\tO\nfirst\tO\n3\tO\nweeks\tO\nafter\tO\nthe\tO\ni\tO\n.\tO\nv\tO\n.\tO\nadministration\tO\nof\tO\nfree\tO\nand\tO\npolymer\tO\n-\tO\nbound\tO\nDOX\tB-Chemical\n,\tO\nall\tO\nanimals\tO\nshowed\tO\na\tO\ntransient\tO\nreduction\tO\nin\tO\nbody\tO\nweight\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmaximal\tO\nreduction\tO\nin\tO\nbody\tO\nweight\tO\nseen\tO\nin\tO\nanimals\tO\nthat\tO\nreceived\tO\npolymer\tO\n-\tO\nbound\tO\nDOX\tB-Chemical\n(\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\nsignificantly\tO\nlower\tO\nthan\tO\nthat\tO\nobserved\tO\nin\tO\nthose\tO\nthat\tO\nreceived\tO\nfree\tO\nDOX\tB-Chemical\n(\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nor\tO\na\tO\nmixture\tO\nof\tO\nthe\tO\nunmodified\tO\nparent\tO\nHPMA\tB-Chemical\ncopolymer\tO\nand\tO\nfree\tO\nDOX\tB-Chemical\n(\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n;\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThroughout\tO\nthe\tO\nstudy\tO\n(\tO\n20\tO\nweeks\tO\n)\tO\n,\tO\ndeaths\tO\nrelated\tO\nto\tO\ncardiotoxicity\tB-Disease\nwere\tO\nobserved\tO\nonly\tO\nin\tO\nanimals\tO\nthat\tO\nreceived\tO\neither\tO\nfree\tO\nDOX\tB-Chemical\nor\tO\nthe\tO\nmixture\tO\nof\tO\nHPMA\tB-Chemical\ncopolymer\tO\nand\tO\nfree\tO\nDOX\tB-Chemical\n;\tO\nin\tO\nthese\tO\ncases\tO\n,\tO\nhistological\tO\ninvestigations\tO\nrevealed\tO\nmarked\tO\nchanges\tO\nin\tO\nthe\tO\nheart\tO\nthat\tO\nwere\tO\nconsistent\tO\nwith\tO\nDOX\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nSequential\tO\nmeasurements\tO\nof\tO\ncardiac\tO\noutput\tO\nin\tO\nsurviving\tO\nanimals\tO\nthat\tO\nreceived\tO\neither\tO\nfree\tO\nDOX\tB-Chemical\nor\tO\nthe\tO\nmixture\tO\nof\tO\nHPMA\tB-Chemical\ncopolymer\tO\nand\tO\nfree\tO\nDOX\tB-Chemical\nshowed\tO\na\tO\nreduction\tO\nof\tO\napproximately\tO\n30\tO\n%\tO\nin\tO\nfunction\tO\nbeginning\tO\nat\tO\nthe\tO\n4th\tO\nweek\tO\nafter\tO\ndrug\tO\nadministration\tO\n.\tO\n\nThe\tO\nheart\tO\nrate\tO\nin\tO\nthese\tO\nanimals\tO\nwas\tO\napproximately\tO\n12\tO\n%\tO\nlower\tO\nthan\tO\nthat\tO\nmeasured\tO\nin\tO\nage\tO\n-\tO\nmatched\tO\ncontrol\tO\nrats\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nAnimals\tO\nthat\tO\nwere\tO\ngiven\tO\nthe\tO\nHPMA\tB-Chemical\ncopolymer\tO\nconjugates\tO\ncontaining\tO\nDOX\tB-Chemical\nexhibited\tO\nno\tO\nsignificant\tO\nchange\tO\nin\tO\ncardiac\tO\noutput\tO\nthroughout\tO\nthe\tO\nstudy\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nno\tO\nsignificant\tO\nhistological\tO\nchange\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\nheart\tO\nof\tO\nanimals\tO\nthat\tO\nreceived\tO\nDOX\tB-Chemical\nin\tO\nthe\tO\nform\tO\nof\tO\nHPMA\tB-Chemical\ncopolymer\tO\nconjugates\tO\nand\tO\nwere\tO\nkilled\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nstudy\tO\n.\tO\n\nHowever\tO\n,\tO\nthese\tO\nanimals\tO\nhad\tO\nshown\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nheart\tO\nrate\tO\nbeginning\tO\nat\tO\n8\tO\nweeks\tO\nafter\tO\ndrug\tO\nadministration\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n400\tO\nWORDS\tO\n)\tO\n\nCorneal\tB-Disease\nulcers\tI-Disease\nassociated\tO\nwith\tO\naerosolized\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nuse\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nWe\tO\nreport\tO\n4\tO\ncases\tO\nof\tO\ncorneal\tB-Disease\nulcers\tI-Disease\nassociated\tO\nwith\tO\ndrug\tB-Disease\nabuse\tI-Disease\n.\tO\n\nThe\tO\npathogenesis\tO\nof\tO\nthese\tO\nulcers\tB-Disease\nand\tO\nmanagement\tO\nof\tO\nthese\tO\npatients\tO\nare\tO\nalso\tO\nreviewed\tO\n.\tO\n\nMETHODS\tO\n:\tO\nReview\tO\nof\tO\nall\tO\ncases\tO\nof\tO\ncorneal\tB-Disease\nulcers\tI-Disease\nassociated\tO\nwith\tO\ndrug\tB-Disease\nabuse\tI-Disease\nseen\tO\nat\tO\nour\tO\ninstitution\tO\nfrom\tO\nJuly\tO\n2006\tO\nto\tO\nDecember\tO\n2006\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFour\tO\npatients\tO\nwith\tO\ncorneal\tB-Disease\nulcers\tI-Disease\nassociated\tO\nwith\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nuse\tO\nwere\tO\nreviewed\tO\n.\tO\n\nAll\tO\ncorneal\tB-Disease\nulcers\tI-Disease\nwere\tO\ncultured\tO\n,\tO\nand\tO\nthe\tO\npatients\tO\nwere\tO\nadmitted\tO\nto\tO\nthe\tO\nhospital\tO\nfor\tO\nintensive\tO\ntopical\tO\nantibiotic\tO\ntreatment\tO\n.\tO\n\nEach\tO\npatient\tO\nreceived\tO\ncomprehensive\tO\nhealth\tO\ncare\tO\n,\tO\nincluding\tO\nmedical\tO\nand\tO\nsubstance\tB-Disease\nabuse\tI-Disease\nconsultations\tO\n.\tO\n\nStreptococcal\tO\norganisms\tO\nwere\tO\nfound\tO\nin\tO\n3\tO\ncases\tO\nand\tO\nCapnocytophaga\tO\nand\tO\nBrevibacterium\tO\ncasei\tO\nin\tO\n1\tO\npatient\tO\n.\tO\n\nThe\tO\ninfections\tB-Disease\nresponded\tO\nto\tO\nantibiotic\tO\ntreatment\tO\n.\tO\n\nTwo\tO\npatients\tO\nneeded\tO\na\tO\nlateral\tO\ntarsorrhaphy\tO\nfor\tO\npersistent\tO\nepithelial\tB-Disease\ndefects\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAerosolized\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nuse\tO\ncan\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\ncorneal\tB-Disease\nulcers\tI-Disease\n.\tO\n\nDrug\tB-Disease\nabuse\tI-Disease\nprovides\tO\nadditional\tO\nchallenges\tO\nfor\tO\nmanagement\tO\n.\tO\n\nNot\tO\nonly\tO\ntreatment\tO\nof\tO\ntheir\tO\ninfections\tB-Disease\nbut\tO\nalso\tO\nthe\tO\noverall\tO\npoor\tO\nhealth\tO\nof\tO\nthe\tO\npatients\tO\nand\tO\nincreased\tO\nrisk\tO\nof\tO\nnoncompliance\tO\nneed\tO\nto\tO\nbe\tO\naddressed\tO\n.\tO\n\nComprehensive\tO\ncare\tO\nmay\tO\nprovide\tO\nthe\tO\npatient\tO\nthe\tO\nopportunity\tO\nto\tO\ndiscontinue\tO\ntheir\tO\nsubstance\tB-Disease\nabuse\tI-Disease\n,\tO\nimprove\tO\ntheir\tO\noverall\tO\nhealth\tO\n,\tO\nand\tO\nprevent\tO\nfuture\tO\ncorneal\tO\ncomplications\tO\n.\tO\n\nTopical\tO\n0\tO\n.\tO\n025\tO\n%\tO\ncapsaicin\tB-Chemical\nin\tO\nchronic\tO\npost\tB-Disease\n-\tI-Disease\nherpetic\tI-Disease\nneuralgia\tI-Disease\n:\tO\nefficacy\tO\n,\tO\npredictors\tO\nof\tO\nresponse\tO\nand\tO\nlong\tO\n-\tO\nterm\tO\ncourse\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\nevaluate\tO\nthe\tO\nefficacy\tO\n,\tO\ntime\tO\n-\tO\ncourse\tO\nof\tO\naction\tO\nand\tO\npredictors\tO\nof\tO\nresponse\tO\nto\tO\ntopical\tO\ncapsaicin\tB-Chemical\n,\tO\n39\tO\npatients\tO\nwith\tO\nchronic\tO\npost\tB-Disease\n-\tI-Disease\nherpetic\tI-Disease\nneuralgia\tI-Disease\n(\tO\nPHN\tB-Disease\n)\tO\n,\tO\nmedian\tO\nduration\tO\n24\tO\nmonths\tO\n,\tO\nwere\tO\ntreated\tO\nwith\tO\n0\tO\n.\tO\n025\tO\n%\tO\ncapsaicin\tB-Chemical\ncream\tO\nfor\tO\n8\tO\nweeks\tO\n.\tO\n\nDuring\tO\ntherapy\tO\nthe\tO\npatients\tO\nrated\tO\ntheir\tO\npain\tB-Disease\non\tO\na\tO\nvisual\tO\nanalogue\tO\nscale\tO\n(\tO\nVAS\tO\n)\tO\nand\tO\na\tO\nverbal\tO\noutcome\tO\nscale\tO\n.\tO\n\nA\tO\nfollow\tO\n-\tO\nup\tO\ninvestigation\tO\nwas\tO\nperformed\tO\n10\tO\n-\tO\n12\tO\nmonths\tO\nafter\tO\nstudy\tO\nonset\tO\non\tO\nthe\tO\npatients\tO\nwho\tO\nhad\tO\nimproved\tO\n.\tO\n\nNineteen\tO\npatients\tO\n(\tO\n48\tO\n.\tO\n7\tO\n%\tO\n)\tO\nsubstantially\tO\nimproved\tO\nafter\tO\nthe\tO\n8\tO\n-\tO\nweek\tO\ntrial\tO\n;\tO\n5\tO\n(\tO\n12\tO\n.\tO\n8\tO\n%\tO\n)\tO\ndiscontinued\tO\ntherapy\tO\ndue\tO\nto\tO\nside\tO\n-\tO\neffects\tO\nsuch\tO\nas\tO\nintolerable\tO\ncapsaicin\tB-Chemical\n-\tO\ninduced\tO\nburning\tO\nsensations\tO\n(\tO\n4\tO\n)\tO\nor\tO\nmastitis\tB-Disease\n(\tO\n1\tO\n)\tO\n;\tO\n15\tO\n(\tO\n38\tO\n.\tO\n5\tO\n%\tO\n)\tO\nreported\tO\nno\tO\nbenefit\tO\n.\tO\n\nThe\tO\ndecrease\tO\nin\tO\nVAS\tO\nratings\tO\nwas\tO\nsignificant\tO\nafter\tO\n2\tO\nweeks\tO\nof\tO\ncontinuous\tO\napplication\tO\n.\tO\n\nOf\tO\nthe\tO\nresponders\tO\n72\tO\n.\tO\n2\tO\n%\tO\nwere\tO\nstill\tO\nimproved\tO\nat\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\n;\tO\nonly\tO\none\tO\n-\tO\nthird\tO\nof\tO\nthem\tO\nhad\tO\ncontinued\tO\napplication\tO\nirregularly\tO\n.\tO\n\nTreatment\tO\neffect\tO\nwas\tO\nnot\tO\ndependent\tO\non\tO\npatient\tO\n'\tO\ns\tO\nage\tO\n,\tO\nduration\tO\nor\tO\nlocalization\tO\nof\tO\nPHN\tB-Disease\n(\tO\ntrigeminal\tO\ninvolvement\tO\nwas\tO\nexcluded\tO\n)\tO\n,\tO\nsensory\tB-Disease\ndisturbance\tI-Disease\nor\tO\npain\tB-Disease\ncharacter\tO\n.\tO\n\nTreatment\tO\nresponse\tO\nwas\tO\nnot\tO\ncorrelated\tO\nwith\tO\nthe\tO\nincidence\tO\n,\tO\ntime\tO\n-\tO\ncourse\tO\nor\tO\nseverity\tO\nof\tO\ncapsaicin\tB-Chemical\n-\tO\ninduced\tO\nburning\tO\n.\tO\n\nIf\tO\nconfirmed\tO\nin\tO\ncontrolled\tO\ntrials\tO\n,\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nresults\tO\nof\tO\nthis\tO\nopen\tO\n,\tO\nnon\tO\n-\tO\nrandomized\tO\nstudy\tO\nmight\tO\nindicate\tO\nthat\tO\nthe\tO\nanalgesic\tO\neffect\tO\nof\tO\ncapsaicin\tB-Chemical\nin\tO\nPHN\tB-Disease\nis\tO\nmediated\tO\nby\tO\nboth\tO\ninterference\tO\nwith\tO\nneuropeptide\tO\nmetabolism\tO\nand\tO\nmorphological\tO\nchanges\tO\n(\tO\nperhaps\tO\ndegeneration\tO\n)\tO\nof\tO\nnociceptive\tO\nafferents\tO\n.\tO\n\nMyo\tB-Chemical\n-\tI-Chemical\ninositol\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nphosphate\tI-Chemical\n(\tO\nMIP\tB-Chemical\n)\tO\nsynthase\tO\ninhibition\tO\n:\tO\nin\tO\n-\tO\nvivo\tO\nstudy\tO\nin\tO\nrats\tO\n.\tO\n\nLithium\tB-Chemical\nand\tO\nvalproate\tB-Chemical\nare\tO\nthe\tO\nprototypic\tO\nmood\tO\nstabilizers\tO\nand\tO\nhave\tO\ndiverse\tO\nstructures\tO\nand\tO\ntargets\tO\n.\tO\n\nBoth\tO\ndrugs\tO\ninfluence\tO\ninositol\tB-Chemical\nmetabolism\tO\n.\tO\n\nLithium\tB-Chemical\ninhibits\tO\nIMPase\tO\nand\tO\nvalproate\tB-Chemical\ninhibits\tO\nMIP\tB-Chemical\nsynthase\tO\n.\tO\n\nThis\tO\nstudy\tO\nshows\tO\nthat\tO\nMIP\tB-Chemical\nsynthase\tO\ninhibition\tO\ndoes\tO\nnot\tO\nreplicate\tO\nor\tO\naugment\tO\nthe\tO\neffects\tO\nof\tO\nlithium\tB-Chemical\nin\tO\nthe\tO\ninositol\tB-Chemical\nsensitive\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nmodel\tO\n.\tO\n\nThis\tO\nlack\tO\nof\tO\neffects\tO\nmay\tO\nstem\tO\nfrom\tO\nthe\tO\nlow\tO\ncontribution\tO\nof\tO\nde\tO\n-\tO\nnovo\tO\nsynthesis\tO\nto\tO\ncellular\tO\ninositol\tB-Chemical\nsupply\tO\nor\tO\nto\tO\nthe\tO\ninhibition\tO\nof\tO\nthe\tO\nde\tO\n-\tO\nnovo\tO\nsynthesis\tO\nby\tO\nlithium\tB-Chemical\nitself\tO\n.\tO\n\nNon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\n-\tO\nassociated\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nwith\tO\ngranular\tO\ntubular\tO\nbasement\tO\nmembrane\tO\ndeposits\tO\n.\tO\n\nAcute\tB-Disease\ntubulo\tI-Disease\n-\tI-Disease\ninterstitial\tI-Disease\nnephritis\tI-Disease\n(\tO\nATIN\tB-Disease\n)\tO\nis\tO\nan\tO\nimportant\tO\ncause\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nresulting\tO\nfrom\tO\na\tO\nvariety\tO\nof\tO\ninsults\tO\n,\tO\nincluding\tO\nimmune\tO\ncomplex\tO\n-\tO\nmediated\tO\ntubulo\tB-Disease\n-\tI-Disease\ninterstitial\tI-Disease\ninjury\tI-Disease\n,\tO\nbut\tO\ndrugs\tO\nsuch\tO\nas\tO\nnon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\n(\tO\nNSAIDs\tO\n)\tO\nare\tO\na\tO\nfar\tO\nmore\tO\nfrequent\tO\ncause\tO\n.\tO\n\nOverall\tO\n,\tO\nas\tO\nan\tO\nentity\tO\n,\tO\nATIN\tB-Disease\nremains\tO\nunder\tO\n-\tO\ndiagnosed\tO\n,\tO\nas\tO\nsymptoms\tO\nresolve\tO\nspontaneously\tO\nif\tO\nthe\tO\nmedication\tO\nis\tO\nstopped\tO\n.\tO\n\nWe\tO\nreport\tO\non\tO\na\tO\n14\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwho\tO\ndeveloped\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n2\tO\nweeks\tO\nafter\tO\naortic\tO\nvalve\tO\nsurgery\tO\n.\tO\n\nHe\tO\nwas\tO\nput\tO\non\tO\naspirin\tB-Chemical\nfollowing\tO\nsurgery\tO\nand\tO\ntook\tO\nibuprofen\tB-Chemical\nfor\tO\nfever\tB-Disease\nfor\tO\nnearly\tO\na\tO\nweek\tO\nprior\tO\nto\tO\npresentation\tO\n.\tO\n\nHe\tO\nthen\tO\npresented\tO\nto\tO\nthe\tO\nemergency\tO\ndepartment\tO\nfeeling\tO\nquite\tO\nill\tO\nand\tO\nwas\tO\nfound\tO\nto\tO\nhave\tO\na\tO\nblood\tB-Chemical\nurea\tI-Chemical\nnitrogen\tI-Chemical\n(\tO\nBUN\tB-Chemical\n)\tO\nconcentration\tO\nof\tO\nof\tO\n147\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\ncreatinine\tB-Chemical\nof\tO\n15\tO\n.\tO\n3\tO\nmg\tO\n/\tO\ndl\tO\nand\tO\nserum\tO\npotassium\tB-Chemical\nof\tO\n8\tO\n.\tO\n7\tO\nmEq\tO\n/\tO\nl\tO\n.\tO\n\nDialysis\tO\nwas\tO\nimmediately\tO\ninitiated\tO\n.\tO\n\nA\tO\nkidney\tO\nbiopsy\tO\nshowed\tO\ninflammatory\tO\ninfiltrate\tO\nconsistent\tO\nwith\tO\nATIN\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nin\tO\nthe\tO\ntubular\tO\nbasement\tO\nmembrane\tO\n(\tO\nTBM\tO\n)\tO\n,\tO\nvery\tO\nintense\tO\ngranular\tO\ndeposits\tO\nof\tO\npolyclonal\tO\nIgG\tO\nand\tO\nC3\tO\nwere\tO\nnoted\tO\n.\tO\n\nHe\tO\nneeded\tO\ndialysis\tO\nfor\tO\n2\tO\nweeks\tO\nand\tO\nwas\tO\ntreated\tO\nsuccessfully\tO\nwith\tO\nsteroids\tB-Chemical\nfor\tO\n6\tO\nmonths\tO\n.\tO\n\nHis\tO\nrenal\tO\nrecovery\tO\nand\tO\ndisappearance\tO\nof\tO\nproteinuria\tB-Disease\ntook\tO\na\tO\nyear\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthis\tO\nis\tO\na\tO\nfirst\tO\nreport\tO\nof\tO\nNSAIDs\tO\n-\tO\nassociated\tO\nATIN\tB-Disease\n,\tO\nshowing\tO\ndeposits\tO\nof\tO\ngranular\tO\nimmune\tO\ncomplex\tO\npresent\tO\nonly\tO\nin\tO\nthe\tO\nTBM\tO\nand\tO\nnot\tO\nin\tO\nthe\tO\nglomeruli\tO\n.\tO\n\nRifampicin\tB-Chemical\n-\tO\nassociated\tO\nsegmental\tO\nnecrotizing\tO\nglomerulonephritis\tB-Disease\nin\tO\nstaphylococcal\tB-Disease\nendocarditis\tI-Disease\n.\tO\n\nSegmental\tO\nnecrotising\tO\nglomerulonephritis\tB-Disease\nhas\tO\nbeen\tO\nreported\tO\nas\tO\ncomplication\tO\nof\tO\nrifampicin\tB-Chemical\ntherapy\tO\nin\tO\npatients\tO\nreceiving\tO\ntreatment\tO\nfor\tO\ntuberculosis\tB-Disease\n.\tO\n\nChanging\tO\nepidemiology\tO\nof\tO\ninfections\tB-Disease\nsuch\tO\nas\tO\ninfective\tB-Disease\nendocarditis\tI-Disease\n(\tO\nIE\tB-Disease\n)\tO\nhas\tO\nled\tO\nto\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\nuse\tO\nof\tO\nrifampicin\tB-Chemical\nfor\tO\nStaphylococcal\tB-Disease\ninfections\tI-Disease\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\na\tO\npatient\tO\nwith\tO\nStaphylococcal\tB-Disease\nIE\tI-Disease\nwho\tO\ndeveloped\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nsecondary\tO\nto\tO\na\tO\nsegmental\tO\nnecrotising\tO\nglomerulonephritis\tB-Disease\nwhile\tO\nbeing\tO\ntreated\tO\nwith\tO\nrifampicin\tB-Chemical\n,\tO\nand\tO\nreview\tO\nthe\tO\nliterature\tO\nregarding\tO\nthis\tO\ncomplication\tO\nof\tO\nrifampicin\tB-Chemical\ntherapy\tO\n.\tO\n\nRate\tO\nof\tO\nYMDD\tO\nmotif\tO\nmutants\tO\nin\tO\nlamivudine\tB-Chemical\n-\tO\nuntreated\tO\nIranian\tO\npatients\tO\nwith\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nB\tI-Disease\nvirus\tI-Disease\ninfection\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nLamivudine\tB-Chemical\nis\tO\nused\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nB\tI-Disease\npatients\tO\n.\tO\n\nRecent\tO\nstudies\tO\nshow\tO\nthat\tO\nthe\tO\nYMDD\tO\nmotif\tO\nmutants\tO\n(\tO\nresistant\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\n)\tO\noccur\tO\nas\tO\nnatural\tO\ngenome\tO\nvariability\tO\nin\tO\nlamivudine\tB-Chemical\n-\tO\nuntreated\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nB\tI-Disease\npatients\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\nwe\tO\naimed\tO\nto\tO\ndetermine\tO\nthe\tO\nrate\tO\nof\tO\nYMDD\tO\nmotif\tO\nmutants\tO\nin\tO\nlamivudine\tB-Chemical\n-\tO\nuntreated\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nB\tI-Disease\npatients\tO\nin\tO\nIran\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n77\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nB\tI-Disease\npatients\tO\nwho\tO\nhad\tO\nnot\tO\nbeen\tO\ntreated\tO\nwith\tO\nlamivudine\tB-Chemical\nwere\tO\nincluded\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nSerum\tO\nsamples\tO\nfrom\tO\npatients\tO\nwere\tO\ntested\tO\nby\tO\npolymerase\tO\nchain\tO\nreaction\tO\n-\tO\nrestriction\tO\nfragment\tO\nlength\tO\npolymorphism\tO\n(\tO\nPCR\tO\n-\tO\nRFLP\tO\n)\tO\nfor\tO\ndetection\tO\nof\tO\nYMDD\tO\nmotif\tO\nmutants\tO\n.\tO\n\nAll\tO\npatients\tO\nwere\tO\nalso\tO\ntested\tO\nfor\tO\nliver\tO\nenzymes\tO\n,\tO\nanti\tO\n-\tO\nHCV\tO\n,\tO\nHBeAg\tB-Chemical\n,\tO\nand\tO\nanti\tO\n-\tO\nHBe\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOf\tO\nthe\tO\n77\tO\npatients\tO\nenrolled\tO\nin\tO\nthe\tO\nstudy\tO\n,\tO\n73\tO\n%\tO\nwere\tO\nmale\tO\nand\tO\n27\tO\n%\tO\nwere\tO\nfemale\tO\n.\tO\n\nMean\tO\nALT\tO\nand\tO\nAST\tO\nlevels\tO\nwere\tO\n124\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n73\tO\n.\tO\n4\tO\nand\tO\n103\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n81\tO\nIU\tO\n/\tO\nl\tO\n,\tO\nrespectively\tO\n.\tO\n\nHBeAg\tB-Chemical\nwas\tO\npositive\tO\nin\tO\n40\tO\n%\tO\nand\tO\nanti\tO\n-\tO\nHBe\tO\nin\tO\n60\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\n.\tO\n\nAnti\tO\n-\tO\nHCV\tO\nwas\tO\nnegative\tO\nin\tO\nall\tO\nof\tO\nthem\tO\n.\tO\n\nYMDD\tO\nmotif\tO\nmutants\tO\nwere\tO\nnot\tO\ndetected\tO\nin\tO\nany\tO\nof\tO\nthe\tO\npatients\tO\ndespite\tO\nthe\tO\nliver\tO\nenzyme\tO\nlevels\tO\nand\tO\nthe\tO\npresence\tO\nof\tO\nHBeAg\tB-Chemical\nor\tO\nanti\tO\n-\tO\nHBe\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nAlthough\tO\nthe\tO\nnatural\tO\noccurrence\tO\nof\tO\nYMDD\tO\nmotif\tO\nmutants\tO\nin\tO\nlamivudine\tB-Chemical\n-\tO\nuntreated\tO\npatients\tO\nwith\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nB\tI-Disease\nhas\tO\nbeen\tO\nreported\tO\n,\tO\nthese\tO\nmutants\tO\nwere\tO\nnot\tO\ndetected\tO\nin\tO\nIranian\tO\nlamivudine\tB-Chemical\n-\tO\nuntreated\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nB\tI-Disease\npatients\tO\n.\tO\n\nBranch\tO\nretinal\tB-Disease\nvein\tI-Disease\nocclusion\tI-Disease\nand\tO\nfluoxetine\tB-Chemical\n.\tO\n\nA\tO\ncase\tO\nof\tO\nbranch\tO\nretinal\tB-Disease\nvein\tI-Disease\nocclusion\tI-Disease\nassociated\tO\nwith\tO\nfluoxetine\tB-Chemical\n-\tO\ninduced\tO\nsecondary\tO\nhypertension\tB-Disease\nis\tO\ndescribed\tO\n.\tO\n\nAlthough\tO\nan\tO\ninfrequent\tO\ncomplication\tO\nof\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitor\tO\ntherapy\tO\n,\tO\nit\tO\nis\tO\nimportant\tO\nthat\tO\nophthalmologists\tO\nare\tO\naware\tO\nthat\tO\nthese\tO\nagents\tO\ncan\tO\ncause\tO\nhypertension\tB-Disease\nbecause\tO\nthis\tO\nclass\tO\nof\tO\ndrugs\tO\nis\tO\nwidely\tO\nprescribed\tO\n.\tO\n\nThe\tO\ndifferential\tO\neffects\tO\nof\tO\nbupivacaine\tB-Chemical\nand\tO\nlidocaine\tB-Chemical\non\tO\nprostaglandin\tB-Chemical\nE2\tI-Chemical\nrelease\tO\n,\tO\ncyclooxygenase\tO\ngene\tO\nexpression\tO\nand\tO\npain\tB-Disease\nin\tO\na\tO\nclinical\tO\npain\tB-Disease\nmodel\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIn\tO\naddition\tO\nto\tO\nblocking\tO\nnociceptive\tO\ninput\tO\nfrom\tO\nsurgical\tO\nsites\tO\n,\tO\nlong\tO\n-\tO\nacting\tO\nlocal\tO\nanesthetics\tO\nmight\tO\ndirectly\tO\nmodulate\tO\ninflammation\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nwe\tO\ndescribe\tO\nthe\tO\nproinflammatory\tO\neffects\tO\nof\tO\nbupivacaine\tB-Chemical\non\tO\nlocal\tO\nprostaglandin\tB-Chemical\nE2\tI-Chemical\n(\tO\nPGE2\tB-Chemical\n)\tO\nproduction\tO\nand\tO\ncyclooxygenase\tO\n(\tO\nCOX\tO\n)\tO\ngene\tO\nexpression\tO\nthat\tO\nincreases\tO\npostoperative\tB-Disease\npain\tI-Disease\nin\tO\nhuman\tO\nsubjects\tO\n.\tO\n\nMETHODS\tO\n:\tO\nSubjects\tO\n(\tO\nn\tO\n=\tO\n114\tO\n)\tO\nundergoing\tO\nextraction\tO\nof\tO\nimpacted\tO\nthird\tO\nmolars\tO\nreceived\tO\neither\tO\n2\tO\n%\tO\nlidocaine\tB-Chemical\nor\tO\n0\tO\n.\tO\n5\tO\n%\tO\nbupivacaine\tB-Chemical\nbefore\tO\nsurgery\tO\nand\tO\neither\tO\nrofecoxib\tB-Chemical\n50\tO\nmg\tO\nor\tO\nplacebo\tO\norally\tO\n90\tO\nmin\tO\nbefore\tO\nsurgery\tO\nand\tO\nfor\tO\nthe\tO\nfollowing\tO\n48\tO\nh\tO\n.\tO\n\nOral\tO\nmucosal\tO\nbiopsies\tO\nwere\tO\ntaken\tO\nbefore\tO\nsurgery\tO\nand\tO\n48\tO\nh\tO\nafter\tO\nsurgery\tO\n.\tO\n\nAfter\tO\nextraction\tO\n,\tO\na\tO\nmicrodialysis\tO\nprobe\tO\nwas\tO\nplaced\tO\nat\tO\nthe\tO\nsurgical\tO\nsite\tO\nfor\tO\nPGE2\tB-Chemical\nand\tO\nthromboxane\tB-Chemical\nB2\tI-Chemical\n(\tO\nTXB2\tB-Chemical\n)\tO\nmeasurements\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nbupivacaine\tB-Chemical\n/\tO\nrofecoxib\tB-Chemical\ngroup\tO\nreported\tO\nsignificantly\tO\nless\tO\npain\tB-Disease\n,\tO\nas\tO\nassessed\tO\nby\tO\na\tO\nvisual\tO\nanalog\tO\nscale\tO\n,\tO\ncompared\tO\nwith\tO\nthe\tO\nother\tO\nthree\tO\ntreatment\tO\ngroups\tO\nover\tO\nthe\tO\nfirst\tO\n4\tO\nh\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nbupivacaine\tB-Chemical\n/\tO\nplacebo\tO\ngroup\tO\nreported\tO\nsignificantly\tO\nmore\tO\npain\tB-Disease\nat\tO\n24\tO\nh\tO\nand\tO\nPGE2\tB-Chemical\nlevels\tO\nduring\tO\nthe\tO\nfirst\tO\n4\tO\nh\tO\nwere\tO\nsignificantly\tO\nhigher\tO\nthan\tO\nthe\tO\nother\tO\nthree\tO\ntreatment\tO\ngroups\tO\n.\tO\n\nMoreover\tO\n,\tO\nbupivacaine\tB-Chemical\nsignificantly\tO\nincreased\tO\nCOX\tO\n-\tO\n2\tO\ngene\tO\nexpression\tO\nat\tO\n48\tO\nh\tO\nas\tO\ncompared\tO\nwith\tO\nthe\tO\nlidocaine\tB-Chemical\n/\tO\nplacebo\tO\ngroup\tO\n.\tO\n\nThromboxane\tB-Chemical\nlevels\tO\nwere\tO\nnot\tO\nsignificantly\tO\naffected\tO\nby\tO\nany\tO\nof\tO\nthe\tO\ntreatments\tO\n,\tO\nindicating\tO\nthat\tO\nthe\tO\neffects\tO\nseen\tO\nwere\tO\nattributable\tO\nto\tO\ninhibition\tO\nof\tO\nCOX\tO\n-\tO\n2\tO\n,\tO\nbut\tO\nnot\tO\nCOX\tO\n-\tO\n1\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nbupivacaine\tB-Chemical\nstimulates\tO\nCOX\tO\n-\tO\n2\tO\ngene\tO\nexpression\tO\nafter\tO\ntissue\tB-Disease\ninjury\tI-Disease\n,\tO\nwhich\tO\nis\tO\nassociated\tO\nwith\tO\nhigher\tO\nPGE2\tB-Chemical\nproduction\tO\nand\tO\npain\tB-Disease\nafter\tO\nthe\tO\nlocal\tO\nanesthetic\tO\neffect\tO\ndissipates\tO\n.\tO\n\np75NTR\tO\nexpression\tO\nin\tO\nrat\tO\nurinary\tO\nbladder\tO\nsensory\tO\nneurons\tO\nand\tO\nspinal\tO\ncord\tO\nwith\tO\ncyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\n.\tO\n\nA\tO\nrole\tO\nfor\tO\nnerve\tO\ngrowth\tO\nfactor\tO\n(\tO\nNGF\tO\n)\tO\nin\tO\ncontributing\tO\nto\tO\nincreased\tO\nvoiding\tO\nfrequency\tO\nand\tO\naltered\tO\nsensation\tO\nfrom\tO\nthe\tO\nurinary\tO\nbladder\tO\nhas\tO\nbeen\tO\nsuggested\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\nexamined\tO\nthe\tO\nexpression\tO\nand\tO\nregulation\tO\nof\tO\ntyrosine\tB-Chemical\nkinase\tO\nreceptors\tO\n(\tO\nTrks\tO\n)\tO\nin\tO\nmicturition\tO\nreflexes\tO\nwith\tO\nurinary\tB-Disease\nbladder\tI-Disease\ninflammation\tI-Disease\n.\tO\n\nThe\tO\npresent\tO\nstudies\tO\nexamine\tO\nthe\tO\nexpression\tO\nand\tO\nregulation\tO\nof\tO\nanother\tO\nreceptor\tO\nknown\tO\nto\tO\nbind\tO\nNGF\tO\n,\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\n,\tO\nafter\tO\nvarious\tO\ndurations\tO\nof\tO\nbladder\tB-Disease\ninflammation\tI-Disease\ninduced\tO\nby\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCYP\tB-Chemical\n)\tO\n.\tO\n\nCYP\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\nincreased\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\nexpression\tO\nin\tO\nthe\tO\nsuperficial\tO\nlateral\tO\nand\tO\nmedial\tO\ndorsal\tO\nhorn\tO\nin\tO\nL1\tO\n-\tO\nL2\tO\nand\tO\nL6\tO\n-\tO\nS1\tO\nspinal\tO\nsegments\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\n-\tO\nimmunoreactive\tO\n(\tO\n-\tO\nIR\tO\n)\tO\ncells\tO\nin\tO\nthe\tO\nlumbosacral\tO\ndorsal\tO\nroot\tO\nganglia\tO\n(\tO\nDRG\tO\n)\tO\nalso\tO\nincreased\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\nwith\tO\nCYP\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\n(\tO\nacute\tO\n,\tO\nintermediate\tO\n,\tO\nand\tO\nchronic\tO\n)\tO\n.\tO\n\nQuantitative\tO\n,\tO\nreal\tO\n-\tO\ntime\tO\npolymerase\tO\nchain\tO\nreaction\tO\nalso\tO\ndemonstrated\tO\nsignificant\tO\nincreases\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\nin\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\nmRNA\tO\nin\tO\nDRG\tO\nwith\tO\nintermediate\tO\nand\tO\nchronic\tO\nCYP\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\n.\tO\n\nRetrograde\tO\ndye\tO\n-\tO\ntracing\tO\ntechniques\tO\nwith\tO\nFastblue\tO\nwere\tO\nused\tO\nto\tO\nidentify\tO\npresumptive\tO\nbladder\tO\nafferent\tO\ncells\tO\nin\tO\nthe\tO\nlumbosacral\tO\nDRG\tO\n.\tO\n\nIn\tO\nbladder\tO\nafferent\tO\ncells\tO\nin\tO\nDRG\tO\n,\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\n-\tO\nIR\tO\nwas\tO\nalso\tO\nincreased\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\nwith\tO\ncystitis\tB-Disease\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nincreases\tO\nin\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\n-\tO\nIR\tO\nin\tO\nDRG\tO\ncell\tO\nbodies\tO\n,\tO\nincreases\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\nin\tO\npericellular\tO\n(\tO\nencircling\tO\nDRG\tO\ncells\tO\n)\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\n-\tO\nIR\tO\nin\tO\nDRG\tO\nalso\tO\nincreased\tO\n.\tO\n\nConfocal\tO\nanalyses\tO\ndemonstrated\tO\nthat\tO\npericellular\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\n-\tO\nIR\tO\nwas\tO\nnot\tO\ncolocalized\tO\nwith\tO\nthe\tO\nglial\tO\nmarker\tO\n,\tO\nglial\tO\nfibrillary\tO\nacidic\tO\nprotein\tO\n(\tO\nGFAP\tO\n)\tO\n.\tO\n\nThese\tO\nstudies\tO\ndemonstrate\tO\nthat\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\nexpression\tO\nin\tO\nmicturition\tO\nreflexes\tO\nis\tO\npresent\tO\nconstitutively\tO\nand\tO\nmodified\tO\nby\tO\nbladder\tB-Disease\ninflammation\tI-Disease\n.\tO\n\nThe\tO\nfunctional\tO\nsignificance\tO\nof\tO\np75\tO\n(\tO\nNTR\tO\n)\tO\nexpression\tO\nin\tO\nmicturition\tO\nreflexes\tO\nremains\tO\nto\tO\nbe\tO\ndetermined\tO\n.\tO\n\nAzathioprine\tB-Chemical\n-\tO\ninduced\tO\nsuicidal\tO\nerythrocyte\tO\ndeath\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAzathioprine\tB-Chemical\nis\tO\nwidely\tO\nused\tO\nas\tO\nan\tO\nimmunosuppressive\tO\ndrug\tO\n.\tO\n\nThe\tO\nside\tO\neffects\tO\nof\tO\nazathioprine\tB-Chemical\ninclude\tO\nanemia\tB-Disease\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nattributed\tO\nto\tO\nbone\tO\nmarrow\tO\nsuppression\tO\n.\tO\n\nAlternatively\tO\n,\tO\nanemia\tB-Disease\ncould\tO\nresult\tO\nfrom\tO\naccelerated\tO\nsuicidal\tO\nerythrocyte\tO\ndeath\tO\nor\tO\neryptosis\tO\n,\tO\nwhich\tO\nis\tO\ncharacterized\tO\nby\tO\nexposure\tO\nof\tO\nphosphatidylserine\tB-Chemical\n(\tO\nPS\tB-Chemical\n)\tO\nat\tO\nthe\tO\nerythrocyte\tO\nsurface\tO\nand\tO\nby\tO\ncell\tO\nshrinkage\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\npresent\tO\nexperiments\tO\nexplored\tO\nwhether\tO\nazathioprine\tB-Chemical\ninfluences\tO\neryptosis\tO\n.\tO\n\nAccording\tO\nto\tO\nannexin\tO\nV\tO\nbinding\tO\n,\tO\nerythrocytes\tO\nfrom\tO\npatients\tO\nindeed\tO\nshowed\tO\na\tO\nsignificant\tO\nincrease\tO\nof\tO\nPS\tB-Chemical\nexposure\tO\nwithin\tO\n1\tO\nweek\tO\nof\tO\ntreatment\tO\nwith\tO\nazathioprine\tB-Chemical\n.\tO\n\nIn\tO\na\tO\nsecond\tO\nseries\tO\n,\tO\ncytosolic\tO\nCa2\tB-Chemical\n+\tO\nactivity\tO\n(\tO\nFluo3\tB-Chemical\nfluorescence\tO\n)\tO\n,\tO\ncell\tO\nvolume\tO\n(\tO\nforward\tO\nscatter\tO\n)\tO\n,\tO\nand\tO\nPS\tB-Chemical\n-\tO\nexposure\tO\n(\tO\nannexin\tO\nV\tO\nbinding\tO\n)\tO\nwere\tO\ndetermined\tO\nby\tO\nFACS\tO\nanalysis\tO\nin\tO\nerythrocytes\tO\nfrom\tO\nhealthy\tO\nvolunteers\tO\n.\tO\n\nRESULTS\tO\n:\tO\nExposure\tO\nto\tO\nazathioprine\tB-Chemical\n(\tO\n>\tO\nor\tO\n=\tO\n2\tO\nmicrog\tO\n/\tO\nmL\tO\n)\tO\nfor\tO\n48\tO\nhours\tO\nincreased\tO\ncytosolic\tO\nCa2\tB-Chemical\n+\tO\nactivity\tO\nand\tO\nannexin\tO\nV\tO\nbinding\tO\nand\tO\ndecreased\tO\nforward\tO\nscatter\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nazathioprine\tB-Chemical\non\tO\nboth\tO\nannexin\tO\nV\tO\nbinding\tO\nand\tO\nforward\tO\nscatter\tO\nwas\tO\nsignificantly\tO\nblunted\tO\nin\tO\nthe\tO\nnominal\tO\nabsence\tO\nof\tO\nextracellular\tO\nCa2\tB-Chemical\n+\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAzathioprine\tB-Chemical\ntriggers\tO\nsuicidal\tO\nerythrocyte\tO\ndeath\tO\n,\tO\nan\tO\neffect\tO\npresumably\tO\ncontributing\tO\nto\tO\nazathioprine\tB-Chemical\n-\tO\ninduced\tO\nanemia\tB-Disease\n.\tO\n\nLevetiracetam\tB-Chemical\nas\tO\nan\tO\nadjunct\tO\nto\tO\nphenobarbital\tB-Chemical\ntreatment\tO\nin\tO\ncats\tO\nwith\tO\nsuspected\tO\nidiopathic\tB-Disease\nepilepsy\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nassess\tO\npharmacokinetics\tO\n,\tO\nefficacy\tO\n,\tO\nand\tO\ntolerability\tO\nof\tO\noral\tO\nlevetiracetam\tB-Chemical\nadministered\tO\nas\tO\nan\tO\nadjunct\tO\nto\tO\nphenobarbital\tB-Chemical\ntreatment\tO\nin\tO\ncats\tO\nwith\tO\npoorly\tO\ncontrolled\tO\nsuspected\tO\nidiopathic\tB-Disease\nepilepsy\tI-Disease\n.\tO\n\nDESIGN\tO\n-\tO\nOpen\tO\n-\tO\nlabel\tO\n,\tO\nnoncomparative\tO\nclinical\tO\ntrial\tO\n.\tO\n\nANIMALS\tO\n:\tO\n12\tO\ncats\tO\nsuspected\tO\nto\tO\nhave\tO\nidiopathic\tB-Disease\nepilepsy\tI-Disease\nthat\tO\nwas\tO\npoorly\tO\ncontrolled\tO\nwith\tO\nphenobarbital\tB-Chemical\nor\tO\nthat\tO\nhad\tO\nunacceptable\tO\nadverse\tO\neffects\tO\nwhen\tO\ntreated\tO\nwith\tO\nphenobarbital\tB-Chemical\n.\tO\n\nPROCEDURES\tO\n:\tO\nCats\tO\nwere\tO\ntreated\tO\nwith\tO\nlevetiracetam\tB-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n[\tO\n9\tO\n.\tO\n1\tO\nmg\tO\n/\tO\nlb\tO\n]\tO\n,\tO\nPO\tO\n,\tO\nq\tO\n8\tO\nh\tO\n)\tO\n.\tO\n\nAfter\tO\na\tO\nminimum\tO\nof\tO\n1\tO\nweek\tO\nof\tO\ntreatment\tO\n,\tO\nserum\tO\nlevetiracetam\tB-Chemical\nconcentrations\tO\nwere\tO\nmeasured\tO\nbefore\tO\nand\tO\n2\tO\n,\tO\n4\tO\n,\tO\nand\tO\n6\tO\nhours\tO\nafter\tO\ndrug\tO\nadministration\tO\n,\tO\nand\tO\nmaximum\tO\nand\tO\nminimum\tO\nserum\tO\nconcentrations\tO\nand\tO\nelimination\tO\nhalf\tO\n-\tO\nlife\tO\nwere\tO\ncalculated\tO\n.\tO\n\nSeizure\tB-Disease\nfrequencies\tO\nbefore\tO\nand\tO\nafter\tO\ninitiation\tO\nof\tO\nlevetiracetam\tB-Chemical\ntreatment\tO\nwere\tO\ncompared\tO\n,\tO\nand\tO\nadverse\tO\neffects\tO\nwere\tO\nrecorded\tO\n.\tO\n\nRESULTS\tO\n:\tO\nMedian\tO\nmaximum\tO\nserum\tO\nlevetiracetam\tB-Chemical\nconcentration\tO\nwas\tO\n25\tO\n.\tO\n5\tO\nmicrog\tO\n/\tO\nmL\tO\n,\tO\nmedian\tO\nminimum\tO\nserum\tO\nlevetiracetam\tB-Chemical\nconcentration\tO\nwas\tO\n8\tO\n.\tO\n3\tO\nmicrog\tO\n/\tO\nmL\tO\n,\tO\nand\tO\nmedian\tO\nelimination\tO\nhalf\tO\n-\tO\nlife\tO\nwas\tO\n2\tO\n.\tO\n9\tO\nhours\tO\n.\tO\n\nMedian\tO\nseizure\tB-Disease\nfrequency\tO\nprior\tO\nto\tO\ntreatment\tO\nwith\tO\nlevetiracetam\tB-Chemical\n(\tO\n2\tO\n.\tO\n1\tO\nseizures\tB-Disease\n/\tO\nmo\tO\n)\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nthan\tO\nmedian\tO\nseizure\tB-Disease\nfrequency\tO\nafter\tO\ninitiation\tO\nof\tO\nlevetiracetam\tB-Chemical\ntreatment\tO\n(\tO\n0\tO\n.\tO\n42\tO\nseizures\tB-Disease\n/\tO\nmo\tO\n)\tO\n,\tO\nand\tO\n7\tO\nof\tO\n10\tO\ncats\tO\nwere\tO\nclassified\tO\nas\tO\nhaving\tO\nresponded\tO\nto\tO\nlevetiracetam\tB-Chemical\ntreatment\tO\n(\tO\nie\tO\n,\tO\nreduction\tO\nin\tO\nseizure\tB-Disease\nfrequency\tO\nof\tO\n>\tO\nor\tO\n=\tO\n50\tO\n%\tO\n)\tO\n.\tO\n\nTwo\tO\ncats\tO\nhad\tO\ntransient\tO\nlethargy\tB-Disease\nand\tO\ninappetence\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\nAND\tO\nCLINICAL\tO\nRELEVANCE\tO\n:\tO\nResults\tO\nsuggested\tO\nthat\tO\nlevetiracetam\tB-Chemical\nis\tO\nwell\tO\ntolerated\tO\nin\tO\ncats\tO\nand\tO\nmay\tO\nbe\tO\nuseful\tO\nas\tO\nan\tO\nadjunct\tO\nto\tO\nphenobarbital\tB-Chemical\ntreatment\tO\nin\tO\ncats\tO\nwith\tO\nidiopathic\tB-Disease\nepilepsy\tI-Disease\n.\tO\n\nSerotonin\tB-Chemical\nreuptake\tO\ninhibitors\tO\n,\tO\nparanoia\tB-Disease\n,\tO\nand\tO\nthe\tO\nventral\tO\nbasal\tO\nganglia\tO\n.\tO\n\nAntidepressants\tO\nhave\tO\npreviously\tO\nbeen\tO\nassociated\tO\nwith\tO\nparanoid\tB-Disease\nreactions\tO\nin\tO\npsychiatric\tO\npatients\tO\n.\tO\n\nFive\tO\ncases\tO\nof\tO\nparanoid\tB-Disease\nexacerbation\tO\nwith\tO\nthe\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitors\tO\nfluoxetine\tB-Chemical\nand\tO\namitriptyline\tB-Chemical\nare\tO\nreported\tO\nhere\tO\n.\tO\n\nElements\tO\ncommon\tO\nto\tO\nthese\tO\ncases\tO\nincluded\tO\na\tO\nhistory\tO\nof\tO\nparanoid\tB-Disease\nsymptomatology\tO\nand\tO\nthe\tO\nconcomitant\tO\noccurrence\tO\nof\tO\ndepressive\tB-Disease\nand\tI-Disease\npsychotic\tI-Disease\nsymptoms\tI-Disease\n.\tO\n\nComplicated\tO\ndepressive\tB-Disease\ndisorders\tI-Disease\n(\tO\nincluding\tO\natypicality\tO\nof\tO\ncourse\tO\nand\tO\nsymptomatology\tO\n,\tO\nchronicity\tO\n,\tO\npsychosis\tB-Disease\n,\tO\nbipolarity\tO\n,\tO\nand\tO\nsecondary\tO\nonset\tO\nin\tO\nthe\tO\ncourse\tO\nof\tO\na\tO\nprimary\tO\npsychosis\tB-Disease\n)\tO\nmay\tO\npresent\tO\nparticular\tO\nvulnerability\tO\nto\tO\nparanoid\tB-Disease\nexacerbations\tO\nassociated\tO\nwith\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitors\tO\n.\tO\n\nAlthough\tO\nthe\tO\npharmacology\tO\nand\tO\nneurobiology\tO\nof\tO\nparanoia\tB-Disease\nremain\tO\ncryptic\tO\n,\tO\nseveral\tO\nmechanisms\tO\n,\tO\nincluding\tO\n5HT3\tO\nreceptor\tO\n-\tO\nmediated\tO\ndopamine\tB-Chemical\nrelease\tO\n,\tO\nbeta\tO\n-\tO\nnoradrenergic\tO\nreceptor\tO\ndownregulation\tO\n,\tO\nor\tO\nGABAB\tO\nreceptor\tO\nupregulation\tO\nacting\tO\nin\tO\nthe\tO\nvicinity\tO\nof\tO\nthe\tO\nventral\tO\nbasal\tO\nganglia\tO\n(\tO\npossibly\tO\nin\tO\nlateral\tO\norbitofrontal\tO\nor\tO\nanterior\tO\ncingulate\tO\ncircuits\tO\n)\tO\n,\tO\nmight\tO\napply\tO\nto\tO\nthis\tO\nphenomenon\tO\n.\tO\n\nThese\tO\ncases\tO\ncall\tO\nattention\tO\nto\tO\npossible\tO\nparanoid\tB-Disease\nexacerbations\tO\nwith\tO\nserotonin\tB-Chemical\nreuptake\tO\nblockers\tO\nin\tO\nselect\tO\npatients\tO\nand\tO\nraise\tO\nneurobiological\tO\nconsiderations\tO\nregarding\tO\nparanoia\tB-Disease\n.\tO\n\nClinical\tO\ncomparison\tO\nof\tO\ncardiorespiratory\tO\neffects\tO\nduring\tO\nunilateral\tO\nand\tO\nconventional\tO\nspinal\tO\nanaesthesia\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nSpinal\tO\nanaesthesia\tO\nis\tO\nwidely\tO\nemployed\tO\nin\tO\nclinical\tO\npractice\tO\nbut\tO\nhas\tO\nthe\tO\nmain\tO\ndrawback\tO\nof\tO\npost\tO\n-\tO\nspinal\tO\nblock\tO\nhypotension\tB-Disease\n.\tO\n\nEfforts\tO\nmust\tO\ntherefore\tO\ncontinue\tO\nto\tO\nbe\tO\nmade\tO\nto\tO\nobviate\tO\nthis\tO\nsetback\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\ncardiovascular\tO\nand\tO\nrespiratory\tO\nchanges\tO\nduring\tO\nunilateral\tO\nand\tO\nconventional\tO\nspinal\tO\nanaesthesia\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWith\tO\nethical\tO\napproval\tO\n,\tO\nwe\tO\nstudied\tO\n74\tO\nAmerican\tO\nSociety\tO\nof\tO\nAnesthesiologists\tO\n(\tO\nASA\tO\n)\tO\n,\tO\nphysical\tO\nstatus\tO\nclass\tO\n1\tO\nand\tO\n2\tO\npatients\tO\nscheduled\tO\nfor\tO\nelective\tO\nunilateral\tO\nlower\tO\nlimb\tO\nsurgery\tO\n.\tO\n\nPatients\tO\nwere\tO\nrandomly\tO\nallocated\tO\ninto\tO\none\tO\nof\tO\ntwo\tO\ngroups\tO\n:\tO\nlateral\tO\nand\tO\nconventional\tO\nspinal\tO\nanaesthesia\tO\ngroups\tO\n.\tO\n\nIn\tO\nthe\tO\nlateral\tO\nposition\tO\nwith\tO\noperative\tO\nside\tO\ndown\tO\n,\tO\npatients\tO\nrecived\tO\n10\tO\nmg\tO\n(\tO\n2mls\tO\n)\tO\nof\tO\n0\tO\n.\tO\n5\tO\n%\tO\nhyperbaric\tO\nbupivacaine\tB-Chemical\nthrough\tO\na\tO\n25\tO\n-\tO\ngauge\tO\nspinal\tO\nneedle\tO\n.\tO\n\nPatients\tO\nin\tO\nthe\tO\nunilateral\tO\ngroup\tO\nwere\tO\nmaintained\tO\nin\tO\nthe\tO\nlateral\tO\nposition\tO\nfor\tO\n15\tO\nminutes\tO\nfollowing\tO\nspinal\tO\ninjection\tO\nwhile\tO\nthose\tO\nin\tO\nthe\tO\nconventional\tO\ngroup\tO\nwere\tO\nturned\tO\nsupine\tO\nimmediately\tO\nafter\tO\ninjection\tO\n.\tO\n\nBlood\tO\npressure\tO\n,\tO\nheart\tO\nrate\tO\n,\tO\nrespiratory\tO\nrate\tO\nand\tO\noxygen\tB-Chemical\nsaturation\tO\nwere\tO\nmonitored\tO\nover\tO\n1\tO\nhour\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThree\tO\npatients\tO\n(\tO\n8\tO\n.\tO\n1\tO\n%\tO\n)\tO\nin\tO\nthe\tO\nunilateral\tO\ngroup\tO\nand\tO\n5\tO\n(\tO\n13\tO\n.\tO\n5\tO\n%\tO\n)\tO\nin\tO\nthe\tO\nconventional\tO\ngroup\tO\ndeveloped\tO\nhypotension\tB-Disease\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n71\tO\n.\tO\n\nFour\tO\n(\tO\n10\tO\n.\tO\n8\tO\n%\tO\n)\tO\npatients\tO\nin\tO\nthe\tO\nconventional\tO\ngroup\tO\nand\tO\n1\tO\n(\tO\n2\tO\n.\tO\n7\tO\n%\tO\n)\tO\nin\tO\nthe\tO\nunilateral\tO\ngroup\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n17\tO\nrequired\tO\nepinephrine\tB-Chemical\ninfusion\tO\nto\tO\ntreat\tO\nhypotension\tB-Disease\n.\tO\n\nPatients\tO\nin\tO\nthe\tO\nconventional\tO\ngroup\tO\nhad\tO\nstatistically\tO\nsignificant\tO\ngreater\tO\nfall\tO\nin\tO\nthe\tO\nsystolic\tO\nblood\tO\npressures\tO\nat\tO\n15\tO\n,\tO\n30\tO\nand\tO\n45\tO\nminutes\tO\nwhen\tO\ncompared\tO\nto\tO\nthe\tO\nbaseline\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n003\tO\n,\tO\n0\tO\n.\tO\n001\tO\nand\tO\n0\tO\n.\tO\n004\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nrespiratory\tO\nrate\tO\nand\tO\noxygen\tB-Chemical\nsaturations\tO\nin\tO\nthe\tO\ntwo\tO\ngroups\tO\nwere\tO\nsimilar\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nCompared\tO\nto\tO\nconventional\tO\nspinal\tO\nanaesthesia\tO\n,\tO\nunilateral\tO\nspinal\tO\nanaesthesia\tO\nwas\tO\nassociated\tO\nwith\tO\nfewer\tO\ncardiovascular\tO\nperturbations\tO\n.\tO\n\nAlso\tO\n,\tO\nthe\tO\ntype\tO\nof\tO\nspinal\tO\nblock\tO\ninstituted\tO\naffected\tO\nneither\tO\nthe\tO\nrespiratory\tO\nrate\tO\nnor\tO\nthe\tO\narterial\tO\noxygen\tB-Chemical\nsaturation\tO\n.\tO\n\nSpectrum\tO\nof\tO\nadverse\tO\nevents\tO\nafter\tO\ngeneric\tO\nHAART\tO\nin\tO\nsouthern\tO\nIndian\tO\nHIV\tB-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\n.\tO\n\nTo\tO\ndetermine\tO\nthe\tO\nincidence\tO\nof\tO\nclinically\tO\nsignificant\tO\nadverse\tO\nevents\tO\nafter\tO\nlong\tO\n-\tO\nterm\tO\n,\tO\nfixed\tO\n-\tO\ndose\tO\n,\tO\ngeneric\tO\nhighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nuse\tO\namong\tO\nHIV\tB-Disease\n-\tI-Disease\ninfected\tI-Disease\nindividuals\tO\nin\tO\nSouth\tO\nIndia\tO\n,\tO\nwe\tO\nexamined\tO\nthe\tO\nexperiences\tO\nof\tO\n3154\tO\nHIV\tB-Disease\n-\tI-Disease\ninfected\tI-Disease\nindividuals\tO\nwho\tO\nreceived\tO\na\tO\nminimum\tO\nof\tO\n3\tO\nmonths\tO\nof\tO\ngeneric\tO\nHAART\tO\nbetween\tO\nFebruary\tO\n1996\tO\nand\tO\nDecember\tO\n2006\tO\nat\tO\na\tO\ntertiary\tO\nHIV\tO\ncare\tO\nreferral\tO\ncenter\tO\nin\tO\nSouth\tO\nIndia\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nregimens\tO\nwere\tO\n3TC\tB-Chemical\n+\tO\nd4T\tB-Chemical\n+\tO\nnevirapine\tB-Chemical\n(\tO\nNVP\tB-Chemical\n)\tO\n(\tO\n54\tO\n.\tO\n8\tO\n%\tO\n)\tO\n,\tO\nzidovudine\tB-Chemical\n(\tO\nAZT\tB-Chemical\n)\tO\n+\tO\n3TC\tB-Chemical\n+\tO\nNVP\tB-Chemical\n(\tO\n14\tO\n.\tO\n5\tO\n%\tO\n)\tO\n,\tO\n3TC\tB-Chemical\n+\tO\nd4T\tB-Chemical\n+\tO\nefavirenz\tB-Chemical\n(\tO\nEFV\tB-Chemical\n)\tO\n(\tO\n20\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nand\tO\nAZT\tB-Chemical\n+\tO\n3TC\tB-Chemical\n+\tO\nEFV\tB-Chemical\n(\tO\n5\tO\n.\tO\n4\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tO\nevents\tO\nand\tO\nmedian\tO\nCD4\tO\nat\tO\ntime\tO\nof\tO\nevent\tO\nwere\tO\nrash\tB-Disease\n(\tO\n15\tO\n.\tO\n2\tO\n%\tO\n;\tO\nCD4\tO\n,\tO\n285\tO\ncells\tO\n/\tO\nmicroL\tO\n)\tO\nand\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\n(\tO\n9\tO\n.\tO\n0\tO\n%\tO\nand\tO\n348\tO\ncells\tO\n/\tO\nmicroL\tO\n)\tO\n.\tO\n\nClinically\tO\nsignificant\tO\nanemia\tB-Disease\n(\tO\nhemoglobin\tO\n<\tO\n7\tO\ng\tO\n/\tO\ndL\tO\n)\tO\nwas\tO\nobserved\tO\nin\tO\n5\tO\n.\tO\n4\tO\n%\tO\nof\tO\npatients\tO\n(\tO\nCD4\tO\n,\tO\n165\tO\ncells\tO\n/\tO\nmicroL\tO\n)\tO\nand\tO\nhepatitis\tB-Disease\n(\tO\nclinical\tO\njaundice\tB-Disease\nwith\tO\nalanine\tB-Chemical\naminotransferase\tO\n>\tO\n5\tO\ntimes\tO\nupper\tO\nlimits\tO\nof\tO\nnormal\tO\n)\tO\nin\tO\n3\tO\n.\tO\n5\tO\n%\tO\nof\tO\npatients\tO\n(\tO\nCD4\tO\n,\tO\n260\tO\ncells\tO\n/\tO\nmicroL\tO\n)\tO\n.\tO\n\nWomen\tO\nwere\tO\nsignificantly\tO\nmore\tO\nlikely\tO\nto\tO\nexperience\tO\nlactic\tB-Disease\nacidosis\tI-Disease\n,\tO\nwhile\tO\nmen\tO\nwere\tO\nsignificantly\tO\nmore\tO\nlikely\tO\nto\tO\nexperience\tO\nimmune\tB-Disease\nreconstitution\tI-Disease\nsyndrome\tI-Disease\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nAmong\tO\nthe\tO\npatients\tO\nwith\tO\n1\tO\nyear\tO\nof\tO\nfollow\tO\n-\tO\nup\tO\n,\tO\nNVP\tB-Chemical\ntherapy\tO\nwas\tO\nsignificantly\tO\nassociated\tO\nwith\tO\ndeveloping\tO\nrash\tB-Disease\nand\tO\nd4T\tB-Chemical\ntherapy\tO\nwith\tO\ndeveloping\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nAnemia\tB-Disease\nand\tO\nhepatitis\tB-Disease\noften\tO\noccur\tO\nwithin\tO\n12\tO\nweeks\tO\nof\tO\ninitiating\tO\ngeneric\tO\nHAART\tO\n.\tO\n\nFrequent\tO\nand\tO\nearly\tO\nmonitoring\tO\nfor\tO\nthese\tO\ntoxicities\tB-Disease\nis\tO\nwarranted\tO\nin\tO\ndeveloping\tO\ncountries\tO\nwhere\tO\ngeneric\tO\nHAART\tO\nis\tO\nincreasingly\tO\navailable\tO\n.\tO\n\nThalidomide\tB-Chemical\nand\tO\nsensory\tB-Disease\nneurotoxicity\tI-Disease\n:\tO\na\tO\nneurophysiological\tO\nstudy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nRecent\tO\nstudies\tO\nconfirmed\tO\na\tO\nhigh\tO\nincidence\tO\nof\tO\nsensory\tB-Disease\naxonal\tI-Disease\nneuropathy\tI-Disease\nin\tO\npatients\tO\ntreated\tO\nwith\tO\ndifferent\tO\ndoses\tO\nof\tO\nthalidomide\tB-Chemical\n.\tO\n\nThe\tO\nstudy\tO\n'\tO\ns\tO\naims\tO\nwere\tO\nto\tO\nmeasure\tO\nvariations\tO\nin\tO\nsural\tO\nnerve\tO\nsensory\tO\naction\tO\npotential\tO\n(\tO\nSAP\tO\n)\tO\namplitude\tO\nin\tO\npatients\tO\nwith\tO\nrefractory\tO\ncutaneous\tB-Disease\nlupus\tI-Disease\nerythematosus\tI-Disease\n(\tO\nCLE\tB-Disease\n)\tO\ntreated\tO\nwith\tO\nthalidomide\tB-Chemical\nand\tO\nuse\tO\nthese\tO\nfindings\tO\nto\tO\nidentify\tO\nthe\tO\nneurotoxic\tB-Disease\npotential\tO\nof\tO\nthalidomide\tB-Chemical\nand\tO\nthe\tO\nrecovery\tO\ncapacity\tO\nof\tO\nsensory\tO\nfibres\tO\nafter\tO\ndiscontinuation\tO\nof\tO\ntreatment\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nClinical\tO\nand\tO\nelectrophysiological\tO\ndata\tO\nin\tO\n12\tO\nfemale\tO\npatients\tO\nwith\tO\nCLE\tB-Disease\nduring\tO\ntreatment\tO\nwith\tO\nthalidomide\tB-Chemical\nand\tO\nup\tO\nto\tO\n47\tO\nmonths\tO\nafter\tO\ndiscontinuation\tO\nof\tO\ntreatment\tO\nwere\tO\nanalysed\tO\n.\tO\n\nSural\tO\nnerve\tO\nSAP\tO\namplitude\tO\nreduction\tO\n>\tO\nor\tO\n=\tO\n40\tO\n%\tO\nwas\tO\nthe\tO\ncriteria\tO\nfor\tO\ndiscontinuing\tO\ntherapy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nDuring\tO\ntreatment\tO\n,\tO\n11\tO\npatients\tO\nshowed\tO\na\tO\nreduction\tO\nin\tO\nsural\tO\nnerve\tO\nSAP\tO\namplitude\tO\ncompared\tO\nto\tO\nbaseline\tO\nvalues\tO\n(\tO\n9\tO\nwith\tO\na\tO\nreduction\tO\n>\tO\nor\tO\n=\tO\n50\tO\n%\tO\nand\tO\n2\tO\n<\tO\n50\tO\n%\tO\n)\tO\n.\tO\n\nOne\tO\npatient\tO\nshowed\tO\nno\tO\nchanges\tO\nin\tO\nSAP\tO\namplitude\tO\n.\tO\n\nFive\tO\npatients\tO\ncomplained\tO\nof\tO\nparesthesias\tB-Disease\nand\tO\nleg\tO\ncramps\tB-Disease\n.\tO\n\nAfter\tO\nthalidomide\tB-Chemical\ntreatment\tO\n,\tO\nsural\tO\nSAP\tO\namplitude\tO\nrecovered\tO\nin\tO\n3\tO\npatients\tO\n.\tO\n\nAt\tO\ndetection\tO\nof\tO\nreduction\tO\nin\tO\nsural\tO\nnerve\tO\nSAP\tO\namplitude\tO\n,\tO\nthe\tO\nmedian\tO\nthalidomide\tB-Chemical\ncumulative\tO\ndose\tO\nwas\tO\n21\tO\n.\tO\n4\tO\ng\tO\n.\tO\n\nThe\tO\nthreshold\tO\nneurotoxic\tB-Disease\ndosage\tO\nis\tO\nlower\tO\nthan\tO\npreviously\tO\nreported\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSural\tO\nnerve\tO\nSAP\tO\namplitude\tO\nreduction\tO\nis\tO\na\tO\nreliable\tO\nand\tO\nsensitive\tO\nmarker\tO\nof\tO\ndegeneration\tO\nand\tO\nrecovery\tO\nof\tO\nsensory\tO\nfibres\tO\n.\tO\n\nThis\tO\nelectrophysiological\tO\nparameter\tO\nprovides\tO\ninformation\tO\nabout\tO\nsubclinical\tO\nneurotoxic\tB-Disease\npotential\tO\nof\tO\nthalidomide\tB-Chemical\nbut\tO\nis\tO\nnot\tO\nhelpful\tO\nin\tO\npredicting\tO\nthe\tO\nappearance\tO\nof\tO\nsensory\tO\nsymptoms\tO\n.\tO\n\nFive\tO\ncases\tO\nof\tO\nencephalitis\tB-Disease\nduring\tO\ntreatment\tO\nof\tO\nloiasis\tB-Disease\nwith\tO\ndiethylcarbamazine\tB-Chemical\n.\tO\n\nFive\tO\ncases\tO\nof\tO\nencephalitis\tB-Disease\nfollowing\tO\ntreatment\tO\nwith\tO\ndiethylcarbamazine\tB-Chemical\n(\tO\nDEC\tB-Chemical\n)\tO\nwere\tO\nobserved\tO\nin\tO\nCongolese\tO\npatients\tO\nwith\tO\nLoa\tO\nloa\tO\nfilariasis\tB-Disease\n.\tO\n\nTwo\tO\ncases\tO\nhad\tO\na\tO\nfatal\tO\noutcome\tO\nand\tO\none\tO\nresulted\tO\nin\tO\nsevere\tO\nsequelae\tO\n.\tO\n\nThe\tO\nnotable\tO\nfact\tO\nwas\tO\nthat\tO\nthis\tO\ncomplication\tO\noccurred\tO\nin\tO\nthree\tO\npatients\tO\nhospitalized\tO\nbefore\tO\ntreatment\tO\nbegan\tO\n,\tO\nwith\tO\nwhom\tO\nparticularly\tO\nstrict\tO\ntherapeutic\tO\nprecautions\tO\nwere\tO\ntaken\tO\n,\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\ninitial\tO\ndose\tO\nless\tO\nthan\tO\n10\tO\nmg\tO\nof\tO\nDEC\tB-Chemical\n,\tO\nvery\tO\ngradual\tO\ndose\tO\nincreases\tO\n,\tO\nand\tO\nassociated\tO\nanti\tO\n-\tO\nallergic\tO\ntreatment\tO\n.\tO\n\nThis\tO\ntype\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\ncomplication\tO\nmay\tO\nnot\tO\nbe\tO\nthat\tO\nuncommon\tO\nin\tO\nhighly\tO\nendemic\tO\nregions\tO\n.\tO\n\nIt\tO\noccurs\tO\nprimarily\tO\n,\tO\nbut\tO\nnot\tO\nexclusively\tO\n,\tO\nin\tO\nsubjects\tO\npresenting\tO\nwith\tO\na\tO\nhigh\tO\nmicrofilarial\tO\nload\tO\n.\tO\n\nThe\tO\nrelationship\tO\nbetween\tO\nthe\tO\noccurrence\tO\nof\tO\nencephalitis\tB-Disease\nand\tO\nthe\tO\ndecrease\tO\nin\tO\nmicrofilaremia\tB-Disease\nis\tO\nevident\tO\n.\tO\n\nThe\tO\npathophysiological\tO\nmechanisms\tO\nare\tO\ndiscussed\tO\nin\tO\nthe\tO\nlight\tO\nof\tO\nthese\tO\nobservations\tO\nand\tO\nthe\tO\nfew\tO\nother\tO\ncomments\tO\non\tO\nthis\tO\nsubject\tO\npublished\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nAmiodarone\tB-Chemical\n-\tO\nrelated\tO\npulmonary\tB-Disease\nmass\tI-Disease\nand\tO\nunique\tO\nmembranous\tB-Disease\nglomerulonephritis\tI-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nvalvular\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n:\tO\nDiagnostic\tO\npitfall\tO\nand\tO\nnew\tO\nfindings\tO\n.\tO\n\nAmiodarone\tB-Chemical\nis\tO\nan\tO\nanti\tO\n-\tO\narrhythmic\tB-Disease\ndrug\tO\nfor\tO\nlife\tO\n-\tO\nthreatening\tO\ntachycardia\tB-Disease\n,\tO\nbut\tO\nvarious\tO\nadverse\tO\neffects\tO\nhave\tO\nbeen\tO\nreported\tO\n.\tO\n\nReported\tO\nherein\tO\nis\tO\nan\tO\nautopsy\tO\ncase\tO\nof\tO\nvalvular\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n,\tO\nin\tO\na\tO\npatient\tO\nwho\tO\ndeveloped\tO\na\tO\nlung\tB-Disease\nmass\tI-Disease\n(\tO\n1\tO\n.\tO\n5\tO\ncm\tO\nin\tO\ndiameter\tO\n)\tO\nand\tO\nproteinuria\tB-Disease\n(\tO\n2\tO\n.\tO\n76\tO\ng\tO\n/\tO\nday\tO\n)\tO\nafter\tO\ntreatment\tO\nwith\tO\namiodarone\tB-Chemical\nfor\tO\na\tO\nlong\tO\ntime\tO\n.\tO\n\nThe\tO\nlung\tB-Disease\nmass\tI-Disease\nwas\tO\nhighly\tO\nsuspected\tO\nto\tO\nbe\tO\nlung\tB-Disease\ncancer\tI-Disease\non\tO\nCT\tO\nand\tO\npositron\tO\nemission\tO\ntomography\tO\n,\tO\nbut\tO\nhistologically\tO\nthe\tO\nlesion\tO\nwas\tO\ncomposed\tO\nof\tO\nlymphoplasmacytic\tO\ninfiltrates\tO\nin\tO\nalveolar\tO\nwalls\tO\nand\tO\nintra\tO\n-\tO\nalveolar\tO\naccumulation\tO\nof\tO\nfoamy\tO\nmacrophages\tO\ncontaining\tO\ncharacteristic\tO\nmyelinoid\tO\nbodies\tO\n,\tO\nindicating\tO\nthat\tO\nit\tO\nwas\tO\nan\tO\namiodarone\tB-Chemical\n-\tO\nrelated\tO\nlesion\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthe\tO\nlung\tO\ntissue\tO\nhad\tO\nunevenly\tO\ndistributed\tO\nhemosiderin\tB-Disease\ndeposition\tO\n,\tO\nand\tO\nabnormally\tO\ntortuous\tO\ncapillaries\tO\nwere\tO\nseen\tO\nin\tO\nthe\tO\nmass\tO\nand\tO\nin\tO\nheavily\tO\nhemosiderotic\tB-Disease\nlung\tO\nportions\tO\noutside\tO\nthe\tO\nmass\tO\n.\tO\n\nIn\tO\nthe\tO\nkidneys\tO\n,\tO\nglomeruli\tO\nhad\tO\nmembrane\tO\nspikes\tO\n,\tO\nprominent\tO\nswelling\tO\nof\tO\npodocytes\tO\nand\tO\nsubepithelial\tO\ndeposits\tO\n,\tO\nwhich\tO\nwere\tO\nsometimes\tO\nlarge\tO\nand\tO\nhump\tO\n-\tO\nlike\tO\n.\tO\n\nAutoimmune\tB-Disease\ndiseases\tI-Disease\n,\tO\nviral\tB-Disease\nhepatitis\tI-Disease\n,\tO\nmalignant\tO\nneoplasms\tB-Disease\nor\tO\nother\tO\ndiseases\tO\nwith\tO\na\tO\nknown\tO\nrelationship\tO\nto\tO\nmembranous\tB-Disease\nglomerulonephritis\tI-Disease\nwere\tO\nnot\tO\nfound\tO\n.\tO\n\nThe\tO\npresent\tO\ncase\tO\nhighlights\tO\nthe\tO\npossibility\tO\nthat\tO\ndifferential\tO\ndiagnosis\tO\nbetween\tO\nan\tO\namiodarone\tB-Chemical\n-\tO\nrelated\tO\npulmonary\tB-Disease\nlesion\tI-Disease\nand\tO\na\tO\nneoplasm\tB-Disease\ncan\tO\nbe\tO\nvery\tO\ndifficult\tO\nradiologically\tO\n,\tO\nand\tO\nsuggests\tO\nthat\tO\nmembranous\tB-Disease\nglomerulonephritis\tI-Disease\nmight\tO\nbe\tO\nanother\tO\npossible\tO\ncomplication\tO\nof\tO\namiodarone\tB-Chemical\ntreatment\tO\n.\tO\n\nRisk\tO\nof\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nassociated\tO\nwith\tO\ninitial\tO\nsulphonylurea\tB-Chemical\ntreatment\tO\nof\tO\npatients\tO\nwith\tO\ntype\tB-Disease\n2\tI-Disease\ndiabetes\tI-Disease\n:\tO\na\tO\nmatched\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nAIMS\tO\n:\tO\nThis\tO\nstudy\tO\nsought\tO\nto\tO\nassess\tO\nthe\tO\nrisk\tO\nof\tO\ndeveloping\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n(\tO\nCAD\tB-Disease\n)\tO\nassociated\tO\nwith\tO\ninitial\tO\ntreatment\tO\nof\tO\ntype\tB-Disease\n2\tI-Disease\ndiabetes\tI-Disease\nwith\tO\ndifferent\tO\nsulphonylureas\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nIn\tO\ntype\tB-Disease\n2\tI-Disease\ndiabetic\tI-Disease\npatients\tO\n,\tO\ncases\tO\nwho\tO\ndeveloped\tO\nCAD\tB-Disease\nwere\tO\ncompared\tO\nretrospectively\tO\nwith\tO\ncontrols\tO\nthat\tO\ndid\tO\nnot\tO\n.\tO\n\nThe\tO\n20\tO\n-\tO\nyear\tO\nrisk\tO\nof\tO\nCAD\tB-Disease\nat\tO\ndiagnosis\tO\nof\tO\ndiabetes\tB-Disease\n,\tO\nusing\tO\nthe\tO\nUKPDS\tO\nrisk\tO\nengine\tO\n,\tO\nwas\tO\nused\tO\nto\tO\nmatch\tO\ncases\tO\nwith\tO\ncontrols\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\n76\tO\ncases\tO\nof\tO\nCAD\tB-Disease\nwere\tO\ncompared\tO\nwith\tO\n152\tO\ncontrols\tO\n.\tO\n\nThe\tO\nhazard\tO\nof\tO\ndeveloping\tO\nCAD\tB-Disease\n(\tO\n95\tO\n%\tO\nCI\tO\n)\tO\nassociated\tO\nwith\tO\ninitial\tO\ntreatment\tO\nincreased\tO\nby\tO\n2\tO\n.\tO\n4\tO\n-\tO\nfold\tO\n(\tO\n1\tO\n.\tO\n3\tO\n-\tO\n4\tO\n.\tO\n3\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n004\tO\n)\tO\nwith\tO\nglibenclamide\tB-Chemical\n;\tO\n2\tO\n-\tO\nfold\tO\n(\tO\n0\tO\n.\tO\n9\tO\n-\tO\n4\tO\n.\tO\n6\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n099\tO\n)\tO\nwith\tO\nglipizide\tB-Chemical\n;\tO\n2\tO\n.\tO\n9\tO\n-\tO\nfold\tO\n(\tO\n1\tO\n.\tO\n6\tO\n-\tO\n5\tO\n.\tO\n1\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n000\tO\n)\tO\nwith\tO\neither\tO\n,\tO\nand\tO\nwas\tO\nunchanged\tO\nwith\tO\nmetformin\tB-Chemical\n.\tO\n\nThe\tO\nhazard\tO\ndecreased\tO\n0\tO\n.\tO\n3\tO\n-\tO\nfold\tO\n(\tO\n0\tO\n.\tO\n7\tO\n-\tO\n1\tO\n.\tO\n7\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n385\tO\n)\tO\nwith\tO\nglimepiride\tB-Chemical\n,\tO\n0\tO\n.\tO\n4\tO\n-\tO\nfold\tO\n(\tO\n0\tO\n.\tO\n7\tO\n-\tO\n1\tO\n.\tO\n3\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n192\tO\n)\tO\nwith\tO\ngliclazide\tB-Chemical\n,\tO\nand\tO\n0\tO\n.\tO\n4\tO\n-\tO\nfold\tO\n(\tO\n0\tO\n.\tO\n7\tO\n-\tO\n1\tO\n.\tO\n1\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n09\tO\n)\tO\nwith\tO\neither\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nInitiating\tO\ntreatment\tO\nof\tO\ntype\tB-Disease\n2\tI-Disease\ndiabetes\tI-Disease\nwith\tO\nglibenclamide\tB-Chemical\nor\tO\nglipizide\tB-Chemical\nis\tO\nassociated\tO\nwith\tO\nincreased\tO\nrisk\tO\nof\tO\nCAD\tB-Disease\nin\tO\ncomparison\tO\nto\tO\ngliclazide\tB-Chemical\nor\tO\nglimepiride\tB-Chemical\n.\tO\n\nIf\tO\nconfirmed\tO\n,\tO\nthis\tO\nmay\tO\nbe\tO\nimportant\tO\nbecause\tO\nmost\tO\nIndian\tO\npatients\tO\nreceive\tO\nthe\tO\ncheaper\tO\nolder\tO\nsulphonylureas\tB-Chemical\n,\tO\nand\tO\npresent\tO\nguidelines\tO\ndo\tO\nnot\tO\ndistinguish\tO\nbetween\tO\nindividual\tO\nagents\tO\n.\tO\n\nReduced\tO\nprogression\tO\nof\tO\nadriamycin\tB-Chemical\nnephropathy\tB-Disease\nin\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\ntreated\tO\nby\tO\nlosartan\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\naim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthe\tO\nantihypertensive\tO\neffects\tO\nof\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\ntype\tO\n-\tO\n1\tO\nreceptor\tO\nblocker\tO\n,\tO\nlosartan\tB-Chemical\n,\tO\nand\tO\nits\tO\npotential\tO\nin\tO\nslowing\tO\ndown\tO\nrenal\tB-Disease\ndisease\tI-Disease\nprogression\tO\nin\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n(\tO\nSHR\tO\n)\tO\nwith\tO\nadriamycin\tB-Chemical\n(\tO\nADR\tB-Chemical\n)\tO\nnephropathy\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nSix\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nfemale\tO\nSHR\tO\nwere\tO\nrandomly\tO\nselected\tO\nin\tO\nsix\tO\ngroups\tO\n.\tO\n\nTwo\tO\ncontrol\tO\ngroups\tO\n(\tO\nSH\tO\n(\tO\n6\tO\n)\tO\n,\tO\nSH\tO\n(\tO\n12\tO\n)\tO\n)\tO\nreceived\tO\nvehicle\tO\n.\tO\n\nGroups\tO\nADR\tB-Chemical\n(\tO\n6\tO\n)\tO\n,\tO\nADR\tB-Chemical\n+\tO\nLOS\tB-Chemical\n(\tO\n6\tO\n)\tO\nand\tO\nADR\tB-Chemical\n(\tO\n12\tO\n)\tO\n,\tO\nand\tO\nADR\tB-Chemical\n+\tO\nLOS\tB-Chemical\n(\tO\n12\tO\n)\tO\nreceived\tO\nADR\tB-Chemical\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nb\tO\n.\tO\nw\tO\n.\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\ntwice\tO\nin\tO\na\tO\n3\tO\n-\tO\nweek\tO\ninterval\tO\n.\tO\n\nGroup\tO\nADR\tB-Chemical\n+\tO\nLOS\tB-Chemical\n(\tO\n6\tO\n)\tO\nreceived\tO\nlosartan\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nb\tO\n.\tO\nw\tO\n.\tO\n/\tO\nday\tO\nby\tO\ngavages\tO\n)\tO\nfor\tO\n6\tO\nweeks\tO\nand\tO\ngroup\tO\nADR\tB-Chemical\n+\tO\nLOS\tB-Chemical\n(\tO\n12\tO\n)\tO\nfor\tO\n12\tO\nweeks\tO\nafter\tO\nsecond\tO\ninjection\tO\nof\tO\nADR\tB-Chemical\n.\tO\n\nAnimals\tO\nwere\tO\nkilled\tO\nafter\tO\n6\tO\nor\tO\n12\tO\nweeks\tO\n,\tO\nrespectively\tO\n.\tO\n\nHaemodynamic\tO\nmeasurements\tO\nwere\tO\nperformed\tO\non\tO\nanaesthetized\tO\nanimals\tO\n,\tO\nblood\tO\nand\tO\nurine\tO\nsamples\tO\nwere\tO\ntaken\tO\nfor\tO\nbiochemical\tO\nanalysis\tO\nand\tO\nthe\tO\nleft\tO\nkidney\tO\nwas\tO\nprocessed\tO\nfor\tO\nmorphological\tO\nstudies\tO\n.\tO\n\nRESULTS\tO\n:\tO\nShort\tO\n-\tO\nterm\tO\nlosartan\tB-Chemical\ntreatment\tO\n,\tO\nbesides\tO\nantihypertensive\tO\neffect\tO\n,\tO\nimproved\tO\nglomerular\tO\nfiltration\tO\nrate\tO\nand\tO\nameliorated\tO\nglomerulosclerosis\tB-Disease\nresulting\tO\nin\tO\ndecreased\tO\nproteinuria\tB-Disease\n.\tO\n\nProlonged\tO\ntreatment\tO\nwith\tO\nlosartan\tB-Chemical\nshowed\tO\nfurther\tO\nreduction\tO\nof\tO\nglomerulosclerosis\tB-Disease\nassociated\tO\nwith\tO\nreduced\tO\nprogression\tO\nof\tO\ntubular\tO\natrophy\tB-Disease\nand\tO\ninterstitial\tB-Disease\nfibrosis\tI-Disease\n,\tO\nthus\tO\npreventing\tO\nheavy\tO\nproteinuria\tB-Disease\nand\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nLosartan\tB-Chemical\nreduced\tO\nuraemia\tB-Disease\nand\tO\nincreased\tO\nurea\tB-Chemical\nclearance\tO\nin\tO\nadvanced\tO\nADR\tB-Chemical\nnephropathy\tB-Disease\nin\tO\nSHR\tO\n.\tO\n\nHistological\tO\nexamination\tO\nshowed\tO\nthat\tO\nlosartan\tB-Chemical\ncould\tO\nprevent\tO\ntubular\tO\natrophy\tB-Disease\n,\tO\ninterstitial\tO\ninfiltration\tO\nand\tO\nfibrosis\tB-Disease\nin\tO\nADR\tB-Chemical\nnephropathy\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nLosartan\tB-Chemical\nreduces\tO\nthe\tO\nrate\tO\nof\tO\nprogression\tO\nof\tO\nADR\tB-Chemical\n-\tO\ninduced\tO\nfocal\tB-Disease\nsegmental\tI-Disease\nglomerulosclerosis\tI-Disease\nto\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\nin\tO\nSHR\tO\n.\tO\n\nThe\tO\nrisks\tO\nof\tO\naprotinin\tO\nand\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\nin\tO\ncardiac\tO\nsurgery\tO\n:\tO\na\tO\none\tO\n-\tO\nyear\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n1188\tO\nconsecutive\tO\npatients\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nOur\tO\naim\tO\nwas\tO\nto\tO\ninvestigate\tO\npostoperative\tO\ncomplications\tO\nand\tO\nmortality\tO\nafter\tO\nadministration\tO\nof\tO\naprotinin\tO\ncompared\tO\nto\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\nin\tO\nan\tO\nunselected\tO\n,\tO\nconsecutive\tO\ncohort\tO\n.\tO\n\nMETHODS\tO\n:\tO\nPerioperative\tO\ndata\tO\nfrom\tO\nconsecutive\tO\ncardiac\tO\nsurgery\tO\npatients\tO\nwere\tO\nprospectively\tO\ncollected\tO\nbetween\tO\nSeptember\tO\n2005\tO\nand\tO\nJune\tO\n2006\tO\nin\tO\na\tO\nuniversity\tO\n-\tO\naffiliated\tO\nclinic\tO\n(\tO\nn\tO\n=\tO\n1188\tO\n)\tO\n.\tO\n\nDuring\tO\nthe\tO\nfirst\tO\n5\tO\nmo\tO\n,\tO\n596\tO\npatients\tO\nreceived\tO\naprotinin\tO\n(\tO\nGroup\tO\nA\tO\n)\tO\n;\tO\nin\tO\nthe\tO\nnext\tO\n5\tO\nmo\tO\n,\tO\n592\tO\npatients\tO\nwere\tO\ntreated\tO\nwith\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\n(\tO\nGroup\tO\nT\tO\n)\tO\n.\tO\n\nExcept\tO\nfor\tO\nantifibrinolytic\tO\ntherapy\tO\n,\tO\nthe\tO\nanesthetic\tO\nand\tO\nsurgical\tO\nprotocols\tO\nremained\tO\nunchanged\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\npre\tO\n-\tO\nand\tO\nintraoperative\tO\nvariables\tO\nwere\tO\ncomparable\tO\nbetween\tO\nthe\tO\ntreatment\tO\ngroups\tO\n.\tO\n\nPostoperatively\tO\n,\tO\na\tO\nsignificantly\tO\nhigher\tO\nincidence\tO\nof\tO\nseizures\tB-Disease\nwas\tO\nfound\tO\nin\tO\nGroup\tO\nT\tO\n(\tO\n4\tO\n.\tO\n6\tO\n%\tO\nvs\tO\n1\tO\n.\tO\n2\tO\n%\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThis\tO\ndifference\tO\nwas\tO\nalso\tO\nsignificant\tO\nin\tO\nthe\tO\nprimary\tO\nvalve\tO\nsurgery\tO\nand\tO\nthe\tO\nhigh\tO\nrisk\tO\nsurgery\tO\nsubgroups\tO\n(\tO\n7\tO\n.\tO\n9\tO\n%\tO\nvs\tO\n1\tO\n.\tO\n2\tO\n%\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n003\tO\n;\tO\n7\tO\n.\tO\n3\tO\n%\tO\nvs\tO\n2\tO\n.\tO\n4\tO\n%\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n035\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nPersistent\tO\natrial\tO\nfibrillation\tO\n(\tO\n7\tO\n.\tO\n9\tO\n%\tO\nvs\tO\n2\tO\n.\tO\n3\tO\n%\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n020\tO\n)\tO\nand\tO\nrenal\tB-Disease\nfailure\tI-Disease\n(\tO\n9\tO\n.\tO\n7\tO\n%\tO\nvs\tO\n1\tO\n.\tO\n7\tO\n%\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n002\tO\n)\tO\nwere\tO\nalso\tO\nmore\tO\ncommon\tO\nin\tO\nGroup\tO\nT\tO\n,\tO\nin\tO\nthe\tO\nprimary\tO\nvalve\tO\nsurgery\tO\nsubgroup\tO\n.\tO\n\nOn\tO\nthe\tO\ncontrary\tO\n,\tO\namong\tO\nprimary\tO\ncoronary\tO\nartery\tO\nbypass\tO\nsurgery\tO\npatients\tO\n,\tO\nthere\tO\nwere\tO\nmore\tO\nacute\tO\nmyocardial\tB-Disease\ninfarctions\tI-Disease\nand\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\nin\tO\nGroup\tO\nA\tO\n(\tO\n5\tO\n.\tO\n8\tO\n%\tO\nvs\tO\n2\tO\n.\tO\n0\tO\n%\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n027\tO\n;\tO\n22\tO\n.\tO\n5\tO\n%\tO\nvs\tO\n15\tO\n.\tO\n2\tO\n%\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n036\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nThe\tO\n1\tO\n-\tO\nyr\tO\nmortality\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nafter\tO\naprotinin\tO\ntreatment\tO\nin\tO\nthe\tO\nhigh\tO\nrisk\tO\nsurgery\tO\ngroup\tO\n(\tO\n17\tO\n.\tO\n7\tO\n%\tO\nvs\tO\n9\tO\n.\tO\n8\tO\n%\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n034\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nBoth\tO\nantifibrinolytic\tO\ndrugs\tO\nbear\tO\nthe\tO\nrisk\tO\nof\tO\nadverse\tO\noutcome\tO\ndepending\tO\non\tO\nthe\tO\ntype\tO\nof\tO\ncardiac\tO\nsurgery\tO\n.\tO\n\nAdministration\tO\nof\tO\naprotinin\tO\nshould\tO\nbe\tO\navoided\tO\nin\tO\ncoronary\tO\nartery\tO\nbypass\tO\ngraft\tO\nand\tO\nhigh\tO\nrisk\tO\npatients\tO\n,\tO\nwhereas\tO\nadministration\tO\nof\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\nis\tO\nnot\tO\nrecommended\tO\nin\tO\nvalve\tO\nsurgery\tO\n.\tO\n\nDelirium\tB-Disease\nin\tO\nan\tO\nelderly\tO\nwoman\tO\npossibly\tO\nassociated\tO\nwith\tO\nadministration\tO\nof\tO\nmisoprostol\tB-Chemical\n.\tO\n\nMisoprostol\tB-Chemical\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nadverse\tO\nreactions\tO\n,\tO\nincluding\tO\ngastrointestinal\tO\nsymptoms\tO\n,\tO\ngynecologic\tO\nproblems\tO\n,\tO\nand\tO\nheadache\tB-Disease\n.\tO\n\nChanges\tO\nin\tO\nmental\tO\nstatus\tO\n,\tO\nhowever\tO\n,\tO\nhave\tO\nnot\tO\nbeen\tO\nreported\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\ncase\tO\nin\tO\nwhich\tO\nan\tO\n89\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nin\tO\na\tO\nlong\tO\n-\tO\nterm\tO\ncare\tO\nfacility\tO\nbecame\tO\nconfused\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\nmisoprostol\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nchange\tO\nin\tO\nmental\tO\nstatus\tO\nwas\tO\nfirst\tO\nreported\tO\nnine\tO\ndays\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\ntherapy\tO\n.\tO\n\nHer\tO\ndelirium\tB-Disease\nsignificantly\tO\nimproved\tO\nafter\tO\nmisoprostol\tB-Chemical\nwas\tO\ndiscontinued\tO\nand\tO\nher\tO\nmental\tO\nstatus\tO\nreturned\tO\nto\tO\nnormal\tO\nwithin\tO\na\tO\nweek\tO\n.\tO\n\nBecause\tO\nno\tO\nother\tO\nfactors\tO\nrelated\tO\nto\tO\nthis\tO\npatient\tO\nchanged\tO\nsignificantly\tO\n,\tO\nthe\tO\ndelirium\tB-Disease\nexperienced\tO\nby\tO\nthis\tO\npatient\tO\npossibly\tO\nresulted\tO\nfrom\tO\nmisoprostol\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\nbiological\tO\nproperties\tO\nof\tO\nthe\tO\noptical\tO\nisomers\tO\nof\tO\npropranolol\tB-Chemical\nand\tO\ntheir\tO\neffects\tO\non\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\n.\tO\n\n1\tO\n.\tO\n\nThe\tO\noptical\tO\nisomers\tO\nof\tO\npropranolol\tB-Chemical\nhave\tO\nbeen\tO\ncompared\tO\nfor\tO\ntheir\tO\nbeta\tO\n-\tO\nblocking\tO\nand\tO\nantiarrhythmic\tO\nactivities\tO\n.\tO\n2\tO\n.\tO\n\nIn\tO\nblocking\tO\nthe\tO\npositive\tO\ninotropic\tO\nand\tO\nchronotropic\tO\nresponses\tO\nto\tO\nisoprenaline\tB-Chemical\n,\tO\n(\tO\n+\tO\n)\tO\n-\tO\npropranolol\tB-Chemical\nhad\tO\nless\tO\nthan\tO\none\tO\nhundredth\tO\nthe\tO\npotency\tO\nof\tO\n(\tO\n-\tO\n)\tO\n-\tO\npropranolol\tB-Chemical\n.\tO\n\nAt\tO\ndose\tO\nlevels\tO\nof\tO\n(\tO\n+\tO\n)\tO\n-\tO\npropranolol\tB-Chemical\nwhich\tO\nattenuated\tO\nthe\tO\nresponses\tO\nto\tO\nisoprenaline\tB-Chemical\n,\tO\nthere\tO\nwas\tO\na\tO\nsignificant\tO\nprolongation\tO\nof\tO\nthe\tO\nPR\tO\ninterval\tO\nof\tO\nthe\tO\nelectrocardiogram\tO\n.\tO\n3\tO\n.\tO\n\nThe\tO\nmetabolic\tO\nresponses\tO\nto\tO\nisoprenaline\tB-Chemical\nin\tO\ndogs\tO\n(\tO\nan\tO\nincrease\tO\nin\tO\ncirculating\tO\nglucose\tB-Chemical\n,\tO\nlactate\tB-Chemical\nand\tO\nfree\tO\nfatty\tB-Chemical\nacids\tI-Chemical\n)\tO\nwere\tO\nall\tO\nblocked\tO\nby\tO\n(\tO\n-\tO\n)\tO\n-\tO\npropranolol\tB-Chemical\n.\tO\n\n(\tO\n+\tO\n)\tO\n-\tO\nPropranolol\tB-Chemical\nhad\tO\nno\tO\neffect\tO\non\tO\nfatty\tB-Chemical\nacid\tI-Chemical\nmobilization\tO\nbut\tO\nsignificantly\tO\nreduced\tO\nthe\tO\nincrements\tO\nin\tO\nboth\tO\nlactate\tB-Chemical\nand\tO\nglucose\tB-Chemical\n.\tO\n4\tO\n.\tO\n\nBoth\tO\nisomers\tO\nof\tO\npropranolol\tB-Chemical\npossessed\tO\nsimilar\tO\ndepressant\tO\npotency\tO\non\tO\nisolated\tO\natrial\tO\nmuscle\tO\ntaken\tO\nfrom\tO\nguinea\tO\n-\tO\npigs\tO\n.\tO\n5\tO\n.\tO\n\nThe\tO\nisomers\tO\nof\tO\npropranolol\tB-Chemical\nexhibited\tO\nsimilar\tO\nlocal\tO\nanaesthetic\tO\npotencies\tO\non\tO\nan\tO\nisolated\tO\nfrog\tO\nnerve\tO\npreparation\tO\nat\tO\na\tO\nlevel\tO\napproximately\tO\nthree\tO\ntimes\tO\nthat\tO\nof\tO\nprocaine\tB-Chemical\n.\tO\n\nThe\tO\nracemic\tO\ncompound\tO\nwas\tO\nsignificantly\tO\nless\tO\npotent\tO\nthan\tO\neither\tO\nisomer\tO\n.\tO\n6\tO\n.\tO\n\nBoth\tO\nisomers\tO\nof\tO\npropranolol\tB-Chemical\nwere\tO\ncapable\tO\nof\tO\npreventing\tO\nadrenaline\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\nin\tO\ncats\tO\nanaesthetized\tO\nwith\tO\nhalothane\tB-Chemical\n,\tO\nbut\tO\nthe\tO\nmean\tO\ndose\tO\nof\tO\n(\tO\n-\tO\n)\tO\n-\tO\npropranolol\tB-Chemical\nwas\tO\n0\tO\n.\tO\n09\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n02\tO\nmg\tO\n/\tO\nkg\tO\nwhereas\tO\nthat\tO\nof\tO\n(\tO\n+\tO\n)\tO\n-\tO\npropranolol\tB-Chemical\nwas\tO\n4\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nAt\tO\nthe\tO\neffective\tO\ndose\tO\nlevel\tO\nof\tO\n(\tO\n+\tO\n)\tO\n-\tO\npropranolol\tB-Chemical\nthere\tO\nwas\tO\na\tO\nsignificant\tO\nprolongation\tO\nof\tO\nthe\tO\nPR\tO\ninterval\tO\nof\tO\nthe\tO\nelectrocardiogram\tO\n.\tO\n\nBlockade\tO\nof\tO\narrhythmias\tB-Disease\nwith\tO\nboth\tO\nisomers\tO\nwas\tO\nsurmountable\tO\nby\tO\nincreasing\tO\nthe\tO\ndose\tO\nof\tO\nadrenaline\tB-Chemical\n.\tO\n7\tO\n.\tO\n\nBoth\tO\nisomers\tO\nof\tO\npropranolol\tB-Chemical\nwere\tO\nalso\tO\ncapable\tO\nof\tO\nreversing\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\ncaused\tO\nby\tO\nouabain\tB-Chemical\nin\tO\nanaesthetized\tO\ncats\tO\nand\tO\ndogs\tO\n.\tO\n\nThe\tO\ndose\tO\nof\tO\n(\tO\n-\tO\n)\tO\n-\tO\npropranolol\tB-Chemical\nwas\tO\nsignificantly\tO\nsmaller\tO\nthan\tO\nthat\tO\nof\tO\n(\tO\n+\tO\n)\tO\n-\tO\npropranolol\tB-Chemical\nin\tO\nboth\tO\nspecies\tO\nbut\tO\nmuch\tO\nhigher\tO\nthan\tO\nthat\tO\nrequired\tO\nto\tO\nproduce\tO\nevidence\tO\nof\tO\nbeta\tO\n-\tO\nblockade\tO\n.\tO\n8\tO\n.\tO\n\nThe\tO\nimplications\tO\nof\tO\nthese\tO\nresults\tO\nare\tO\ndiscussed\tO\n.\tO\n\nTopotecan\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nradiotherapy\tO\nin\tO\nunresectable\tO\nglioblastoma\tB-Disease\n:\tO\na\tO\nphase\tO\n2\tO\nstudy\tO\n.\tO\n\nImproving\tO\nglioblastoma\tB-Disease\nmultiforme\tI-Disease\n(\tO\nGBM\tB-Disease\n)\tO\ntreatment\tO\nwith\tO\nradio\tO\n-\tO\nchemotherapy\tO\nremains\tO\na\tO\nchallenge\tO\n.\tO\n\nTopotecan\tB-Chemical\nis\tO\nan\tO\nattractive\tO\noption\tO\nas\tO\nit\tO\nexhibits\tO\ngrowth\tO\ninhibition\tO\nof\tO\nhuman\tO\nglioma\tB-Disease\nas\tO\nwell\tO\nas\tO\nbrain\tO\npenetration\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nassessed\tO\nthe\tO\ncombination\tO\nof\tO\nradiotherapy\tO\n(\tO\n60\tO\nGy\tO\n/\tO\n30\tO\nfractions\tO\n/\tO\n40\tO\ndays\tO\n)\tO\nand\tO\ntopotecan\tB-Chemical\n(\tO\n0\tO\n.\tO\n9\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n/\tO\nday\tO\non\tO\ndays\tO\n1\tO\n-\tO\n5\tO\non\tO\nweeks\tO\n1\tO\n,\tO\n3\tO\nand\tO\n5\tO\n)\tO\nin\tO\n50\tO\nadults\tO\nwith\tO\nhistologically\tO\nproven\tO\nand\tO\nuntreated\tO\nGBM\tB-Disease\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nnon\tO\n-\tO\nhematological\tO\ntoxicities\tB-Disease\nwas\tO\nlow\tO\nand\tO\ngrade\tO\n3\tO\n-\tO\n4\tO\nhematological\tO\ntoxicities\tB-Disease\nwere\tO\nreported\tO\nin\tO\n20\tO\npatients\tO\n(\tO\nmainly\tO\nlymphopenia\tB-Disease\nand\tO\nneutropenia\tB-Disease\n)\tO\n.\tO\n\nPartial\tO\nresponse\tO\nand\tO\nstabilization\tO\nrates\tO\nwere\tO\n2\tO\n%\tO\nand\tO\n32\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nwith\tO\nan\tO\noverall\tO\ntime\tO\nto\tO\nprogression\tO\nof\tO\n12\tO\nweeks\tO\n.\tO\n\nOne\tO\n-\tO\nyear\tO\noverall\tO\nsurvival\tO\n(\tO\nOS\tO\n)\tO\nrate\tO\nwas\tO\n42\tO\n%\tO\n,\tO\nwith\tO\na\tO\nmedian\tO\nOS\tO\nof\tO\n40\tO\nweeks\tO\n.\tO\n\nTopotecan\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nradiotherapy\tO\nwas\tO\nwell\tO\ntolerated\tO\n.\tO\n\nHowever\tO\n,\tO\nwhile\tO\nresponse\tO\nand\tO\nstabilization\tO\nconcerned\tO\none\tO\n-\tO\nthird\tO\nof\tO\nthe\tO\npatients\tO\n,\tO\nthe\tO\nstudy\tO\ndid\tO\nnot\tO\nshow\tO\nincreased\tO\nbenefits\tO\nin\tO\nterms\tO\nof\tO\nsurvival\tO\nin\tO\npatients\tO\nwith\tO\nunresectable\tO\nGBM\tB-Disease\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nlithium\tB-Chemical\ntherapy\tO\nleading\tO\nto\tO\nhyperparathyroidism\tB-Disease\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nThis\tO\npaper\tO\nreviews\tO\nthe\tO\neffect\tO\nof\tO\nchronic\tO\nlithium\tB-Chemical\ntherapy\tO\non\tO\nserum\tO\ncalcium\tB-Chemical\nlevel\tO\nand\tO\nparathyroid\tO\nglands\tO\n,\tO\nits\tO\npathogenesis\tO\n,\tO\nand\tO\ntreatment\tO\noptions\tO\n.\tO\n\nWe\tO\nexamined\tO\nthe\tO\ncase\tO\nof\tO\na\tO\nlithium\tB-Chemical\n-\tO\ntreated\tO\npatient\tO\nwho\tO\nhad\tO\nrecurrent\tO\nhypercalcemia\tB-Disease\nto\tO\nbetter\tO\nunderstand\tO\nthe\tO\ndisease\tO\nprocess\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nPrimary\tB-Disease\nhyperparathyroidism\tI-Disease\nis\tO\na\tO\nrare\tO\nbut\tO\npotentially\tO\nlife\tO\n-\tO\nthreatening\tO\nside\tO\neffect\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nlithium\tB-Chemical\ntherapy\tO\n.\tO\n\nCareful\tO\npatient\tO\nselection\tO\nand\tO\nlong\tO\n-\tO\nterm\tO\nfollow\tO\n-\tO\nup\tO\ncan\tO\nreduce\tO\nmorbidity\tO\n.\tO\n\nPRACTICAL\tO\nIMPLICATIONS\tO\n:\tO\nAs\tO\nmuch\tO\nas\tO\n15\tO\n%\tO\nof\tO\nlithium\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nbecome\tO\nhypercalcemic\tB-Disease\n.\tO\n\nBy\tO\nroutinely\tO\nmonitoring\tO\nserum\tO\ncalcium\tB-Chemical\nlevels\tO\n,\tO\nhealthcare\tO\nproviders\tO\ncan\tO\nimprove\tO\nthe\tO\nquality\tO\nof\tO\nlife\tO\nof\tO\nthis\tO\npatient\tO\ngroup\tO\n.\tO\n\nComparison\tO\nof\tO\nlaryngeal\tO\nmask\tO\nwith\tO\nendotracheal\tO\ntube\tO\nfor\tO\nanesthesia\tO\nin\tO\nendoscopic\tO\nsinus\tO\nsurgery\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ncompare\tO\nsurgical\tO\nconditions\tO\n,\tO\nincluding\tO\nthe\tO\namount\tO\nof\tO\nintraoperative\tO\nbleeding\tB-Disease\nas\tO\nwell\tO\nas\tO\nintraoperative\tO\nblood\tO\npressure\tO\n,\tO\nduring\tO\nfunctional\tO\nendoscopic\tO\nsinus\tO\nsurgery\tO\n(\tO\nFESS\tO\n)\tO\nusing\tO\nflexible\tO\nreinforced\tO\nlaryngeal\tO\nmask\tO\nairway\tO\n(\tO\nFRLMA\tO\n)\tO\nversus\tO\nendotracheal\tO\ntube\tO\n(\tO\nETT\tO\n)\tO\nin\tO\nmaintaining\tO\ncontrolled\tO\nhypotension\tB-Disease\nanesthesia\tO\ninduced\tO\nby\tO\npropofol\tB-Chemical\n-\tO\nremifentanil\tB-Chemical\ntotal\tO\ni\tO\n.\tO\nv\tO\n.\tO\nanesthesia\tO\n(\tO\nTIVA\tO\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nSixty\tO\nnormotensive\tO\nAmerican\tO\nSociety\tO\nof\tO\nAnesthesiologists\tO\nI\tO\n-\tO\nII\tO\nadult\tO\npatients\tO\nundergoing\tO\nFESS\tO\nunder\tO\ncontrolled\tO\nhypotension\tB-Disease\nanesthesia\tO\ncaused\tO\nby\tO\npropofol\tB-Chemical\n-\tO\nremifentanil\tB-Chemical\n-\tO\nTIVA\tO\nwere\tO\nrandomly\tO\nassigned\tO\ninto\tO\ntwo\tO\ngroups\tO\n:\tO\ngroup\tO\nI\tO\n,\tO\nFRLMA\tO\n;\tO\ngroup\tO\nII\tO\n,\tO\nETT\tO\n.\tO\n\nHemorrhage\tB-Disease\nwas\tO\nmeasured\tO\nand\tO\nthe\tO\nvisibility\tO\nof\tO\nthe\tO\noperative\tO\nfield\tO\nwas\tO\nevaluated\tO\naccording\tO\nto\tO\na\tO\nsix\tO\n-\tO\npoint\tO\nscale\tO\n.\tO\n\nRESULTS\tO\n:\tO\nControlled\tO\nhypotension\tB-Disease\nwas\tO\nachieved\tO\nwithin\tO\na\tO\nshorter\tO\nperiod\tO\nusing\tO\nlaryngeal\tO\nmask\tO\nusing\tO\nlower\tO\nrates\tO\nof\tO\nremifentanil\tB-Chemical\ninfusion\tO\nand\tO\nlower\tO\ntotal\tO\ndose\tO\nof\tO\nremifentanil\tB-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\nsummary\tO\n,\tO\nour\tO\nresults\tO\nindicate\tO\nthat\tO\nairway\tO\nmanagement\tO\nusing\tO\nFRLMA\tO\nduring\tO\ncontrolled\tO\nhypotension\tB-Disease\nanesthesia\tO\nprovided\tO\nbetter\tO\nsurgical\tO\nconditions\tO\nin\tO\nterms\tO\nof\tO\nquality\tO\nof\tO\noperative\tO\nfield\tO\nand\tO\nblood\tO\nloss\tO\nand\tO\nallowed\tO\nfor\tO\nconvenient\tO\ninduced\tO\nhypotension\tB-Disease\nwith\tO\nlow\tO\ndoses\tO\nof\tO\nremifentanil\tB-Chemical\nduring\tO\nTIVA\tO\nin\tO\npatients\tO\nundergoing\tO\nFESS\tO\n.\tO\n\nNonalcoholic\tB-Disease\nfatty\tI-Disease\nliver\tI-Disease\ndisease\tI-Disease\nduring\tO\nvalproate\tB-Chemical\ntherapy\tO\n.\tO\n\nValproic\tB-Chemical\nacid\tI-Chemical\n(\tO\nVPA\tB-Chemical\n)\tO\nis\tO\neffective\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nmany\tO\ntypes\tO\nof\tO\nepilepsy\tB-Disease\n,\tO\nbut\tO\nits\tO\nuse\tO\ncan\tO\nbe\tO\nassociated\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nbody\tO\nweight\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nnonalcoholic\tB-Disease\nfatty\tI-Disease\nliver\tI-Disease\ndisease\tI-Disease\n(\tO\nNAFLD\tB-Disease\n)\tO\narising\tO\nin\tO\na\tO\nchild\tO\nwho\tO\ndeveloped\tO\nobesity\tB-Disease\nduring\tO\nVPA\tB-Chemical\ntreatment\tO\n.\tO\n\nLaboratory\tO\ndata\tO\nrevealed\tO\nhyperinsulinemia\tB-Disease\nwith\tO\ninsulin\tB-Disease\nresistance\tI-Disease\n.\tO\n\nAfter\tO\nthe\tO\nwithdrawal\tO\nof\tO\nVPA\tB-Chemical\ntherapy\tO\n,\tO\nour\tO\npatient\tO\nshowed\tO\na\tO\nsignificant\tO\nweight\tB-Disease\nloss\tI-Disease\n,\tO\na\tO\ndecrease\tO\nof\tO\nbody\tO\nmass\tO\nindex\tO\n,\tO\nand\tO\nnormalization\tO\nof\tO\nmetabolic\tO\nand\tO\nendocrine\tO\nparameters\tO\n;\tO\nmoreover\tO\n,\tO\nultrasound\tO\nmeasurements\tO\nshowed\tO\na\tO\ncomplete\tO\nnormalization\tO\n.\tO\n\nThe\tO\npresent\tO\ncase\tO\nsuggests\tO\nthat\tO\nobesity\tB-Disease\n,\tO\nhyperinsulinemia\tB-Disease\n,\tO\ninsulin\tB-Disease\nresistance\tI-Disease\n,\tO\nand\tO\nlong\tO\n-\tO\nterm\tO\ntreatment\tO\nwith\tO\nVPA\tB-Chemical\nmay\tO\nbe\tO\nall\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nNAFLD\tB-Disease\n;\tO\nthis\tO\nside\tO\neffect\tO\nis\tO\nreversible\tO\nafter\tO\nVPA\tB-Chemical\nwithdrawal\tO\n.\tO\n\nCarbimazole\tB-Chemical\ninduced\tO\nANCA\tB-Disease\npositive\tI-Disease\nvasculitis\tI-Disease\n.\tO\n\nAnti\tB-Chemical\n-\tI-Chemical\nthyroid\tI-Chemical\ndrugs\tI-Chemical\n,\tO\nlike\tO\ncarbimazole\tB-Chemical\nand\tO\npropylthiouracil\tB-Chemical\n(\tO\nPTU\tB-Chemical\n)\tO\nare\tO\ncommonly\tO\nprescribed\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nhyperthyroidism\tB-Disease\n.\tO\n\nOne\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthe\tO\nside\tO\neffects\tO\nof\tO\nantithyroid\tB-Chemical\nmedications\tI-Chemical\n.\tO\n\nAntineutrophil\tB-Disease\ncytoplasmic\tI-Disease\nantibody\tI-Disease\n(\tI-Disease\nANCA\tI-Disease\n)\tI-Disease\n-\tI-Disease\n-\tI-Disease\nassociated\tI-Disease\nvasculitis\tI-Disease\nis\tO\na\tO\npotentially\tO\nlife\tO\n-\tO\nthreatening\tO\nadverse\tO\neffect\tO\nof\tO\nantithyroidmedications\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\npatient\tO\nwith\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\nwho\tO\ndeveloped\tO\nANCA\tO\npositive\tO\ncarbimazole\tB-Chemical\ninduced\tO\nvasculitis\tB-Disease\n.\tO\n\nThe\tO\nepisode\tO\nwas\tO\ncharacterized\tO\nby\tO\na\tO\nvasculitic\tB-Disease\nskin\tB-Disease\nrash\tI-Disease\nassociated\tO\nwith\tO\nlarge\tO\njoint\tO\narthritis\tB-Disease\n,\tO\npyrexia\tB-Disease\nand\tO\nparotiditis\tB-Disease\nbut\tO\nno\tO\nrenal\tO\nor\tO\npulmonary\tO\ninvolvement\tO\n.\tO\n\nHe\tO\nwas\tO\nreferred\tO\nto\tO\nus\tO\nfor\tO\nneurological\tO\nevaluation\tO\nbecause\tO\nhe\tO\nhad\tO\ndifficulty\tO\nin\tO\ngetting\tO\nup\tO\nfrom\tO\nsquatting\tO\nposition\tO\nand\tO\nwas\tO\nsuspected\tO\nto\tO\nhave\tO\nmyositis\tB-Disease\n.\tO\n\nCarbimazole\tB-Chemical\nand\tO\nmethimazole\tB-Chemical\nhave\tO\na\tO\nlower\tO\nincidence\tO\nof\tO\nreported\tO\nANCA\tO\npositive\tO\nside\tO\neffects\tO\nthan\tO\nPUT\tO\n.\tO\n\nTo\tO\nthe\tO\nbest\tO\nof\tO\nour\tO\nknowledge\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\nANCA\tO\npositive\tO\ncarbimazole\tB-Chemical\ninduced\tO\nvasculitis\tB-Disease\ncase\tO\nreported\tO\nfrom\tO\nIndia\tO\n.\tO\n\nAspirin\tB-Chemical\nfor\tO\nthe\tO\nprimary\tO\nprevention\tO\nof\tO\ncardiovascular\tO\nevents\tO\n:\tO\nan\tO\nupdate\tO\nof\tO\nthe\tO\nevidence\tO\nfor\tO\nthe\tO\nU\tO\n.\tO\nS\tO\n.\tO\n\nPreventive\tO\nServices\tO\nTask\tO\nForce\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCoronary\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\nand\tO\ncerebrovascular\tB-Disease\ndisease\tI-Disease\nare\tO\nleading\tO\ncauses\tO\nof\tO\ndeath\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tO\n\nIn\tO\n2002\tO\n,\tO\nthe\tO\nU\tO\n.\tO\nS\tO\n.\tO\n\nPreventive\tO\nServices\tO\nTask\tO\nForce\tO\n(\tO\nUSPSTF\tO\n)\tO\nstrongly\tO\nrecommended\tO\nthat\tO\nclinicians\tO\ndiscuss\tO\naspirin\tB-Chemical\nwith\tO\nadults\tO\nwho\tO\nare\tO\nat\tO\nincreased\tO\nrisk\tO\nfor\tO\ncoronary\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nbenefits\tO\nand\tO\nharms\tO\nof\tO\ntaking\tO\naspirin\tB-Chemical\nfor\tO\nthe\tO\nprimary\tO\nprevention\tO\nof\tO\nmyocardial\tB-Disease\ninfarctions\tI-Disease\n,\tO\nstrokes\tB-Disease\n,\tO\nand\tO\ndeath\tO\n.\tO\n\nDATA\tO\nSOURCES\tO\n:\tO\nMEDLINE\tO\nand\tO\nCochrane\tO\nLibrary\tO\n(\tO\nsearch\tO\ndates\tO\n,\tO\n1\tO\nJanuary\tO\n2001\tO\nto\tO\n28\tO\nAugust\tO\n2008\tO\n)\tO\n,\tO\nrecent\tO\nsystematic\tO\nreviews\tO\n,\tO\nreference\tO\nlists\tO\nof\tO\nretrieved\tO\narticles\tO\n,\tO\nand\tO\nsuggestions\tO\nfrom\tO\nexperts\tO\n.\tO\n\nSTUDY\tO\nSELECTION\tO\n:\tO\nEnglish\tO\n-\tO\nlanguage\tO\nrandomized\tO\n,\tO\ncontrolled\tO\ntrials\tO\n(\tO\nRCTs\tO\n)\tO\n;\tO\ncase\tO\n-\tO\ncontrol\tO\nstudies\tO\n;\tO\nmeta\tO\n-\tO\nanalyses\tO\n;\tO\nand\tO\nsystematic\tO\nreviews\tO\nof\tO\naspirin\tB-Chemical\nversus\tO\ncontrol\tO\nfor\tO\nthe\tO\nprimary\tO\nprevention\tO\nof\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n(\tO\nCVD\tB-Disease\n)\tO\nwere\tO\nselected\tO\nto\tO\nanswer\tO\nthe\tO\nfollowing\tO\nquestions\tO\n:\tO\nDoes\tO\naspirin\tB-Chemical\ndecrease\tO\ncoronary\tO\nheart\tO\nevents\tO\n,\tO\nstrokes\tB-Disease\n,\tO\ndeath\tO\nfrom\tO\ncoronary\tO\nheart\tO\nevents\tO\nor\tO\nstroke\tB-Disease\n,\tO\nor\tO\nall\tO\n-\tO\ncause\tO\nmortality\tO\nin\tO\nadults\tO\nwithout\tO\nknown\tO\nCVD\tB-Disease\n?\tO\n\nDoes\tO\naspirin\tB-Chemical\nincrease\tO\ngastrointestinal\tB-Disease\nbleeding\tI-Disease\nor\tO\nhemorrhagic\tB-Disease\nstrokes\tI-Disease\n?\tO\n\nDATA\tO\nEXTRACTION\tO\n:\tO\nAll\tO\nstudies\tO\nwere\tO\nreviewed\tO\n,\tO\nabstracted\tO\n,\tO\nand\tO\nrated\tO\nfor\tO\nquality\tO\nby\tO\nusing\tO\npredefined\tO\nUSPSTF\tO\ncriteria\tO\n.\tO\n\nDATA\tO\nSYNTHESIS\tO\n:\tO\nNew\tO\nevidence\tO\nfrom\tO\n1\tO\ngood\tO\n-\tO\nquality\tO\nRCT\tO\n,\tO\n1\tO\ngood\tO\n-\tO\nquality\tO\nmeta\tO\n-\tO\nanalysis\tO\n,\tO\nand\tO\n2\tO\nfair\tO\n-\tO\nquality\tO\nsubanalyses\tO\nof\tO\nRCTs\tO\ndemonstrates\tO\nthat\tO\naspirin\tB-Chemical\nuse\tO\nreduces\tO\nthe\tO\nnumber\tO\nof\tO\nCVD\tB-Disease\nevents\tO\nin\tO\npatients\tO\nwithout\tO\nknown\tO\nCVD\tB-Disease\n.\tO\n\nMen\tO\nin\tO\nthese\tO\nstudies\tO\nexperienced\tO\nfewer\tO\nmyocardial\tB-Disease\ninfarctions\tI-Disease\nand\tO\nwomen\tO\nexperienced\tO\nfewer\tO\nischemic\tO\nstrokes\tB-Disease\n.\tO\n\nAspirin\tB-Chemical\ndoes\tO\nnot\tO\nseem\tO\nto\tO\naffect\tO\nCVD\tB-Disease\nmortality\tO\nor\tO\nall\tO\n-\tO\ncause\tO\nmortality\tO\nin\tO\neither\tO\nmen\tO\nor\tO\nwomen\tO\n.\tO\n\nThe\tO\nuse\tO\nof\tO\naspirin\tB-Chemical\nfor\tO\nprimary\tO\nprevention\tO\nincreases\tO\nthe\tO\nrisk\tO\nfor\tO\nmajor\tO\nbleeding\tB-Disease\nevents\tO\n,\tO\nprimarily\tO\ngastrointestinal\tB-Disease\nbleeding\tI-Disease\nevents\tO\n,\tO\nin\tO\nboth\tO\nmen\tO\nand\tO\nwomen\tO\n.\tO\n\nMen\tO\nhave\tO\nan\tO\nincreased\tO\nrisk\tO\nfor\tO\nhemorrhagic\tB-Disease\nstrokes\tI-Disease\nwith\tO\naspirin\tB-Chemical\nuse\tO\n.\tO\n\nA\tO\nnew\tO\nRCT\tO\nand\tO\nmeta\tO\n-\tO\nanalysis\tO\nsuggest\tO\nthat\tO\nthe\tO\nrisk\tO\nfor\tO\nhemorrhagic\tB-Disease\nstrokes\tI-Disease\nin\tO\nwomen\tO\nis\tO\nnot\tO\nstatistically\tO\nsignificantly\tO\nincreased\tO\n.\tO\n\nLIMITATIONS\tO\n:\tO\nNew\tO\nevidence\tO\non\tO\naspirin\tB-Chemical\nfor\tO\nthe\tO\nprimary\tO\nprevention\tO\nof\tO\nCVD\tB-Disease\nis\tO\nlimited\tO\n.\tO\n\nThe\tO\ndose\tO\nof\tO\naspirin\tB-Chemical\nused\tO\nin\tO\nthe\tO\nRCTs\tO\nvaried\tO\n,\tO\nwhich\tO\nprevented\tO\nthe\tO\nestimation\tO\nof\tO\nthe\tO\nmost\tO\nappropriate\tO\ndose\tO\nfor\tO\nprimary\tO\nprevention\tO\n.\tO\n\nSeveral\tO\nof\tO\nthe\tO\nRCTs\tO\nwere\tO\nconducted\tO\nwithin\tO\npopulations\tO\nof\tO\nhealth\tO\nprofessionals\tO\n,\tO\nwhich\tO\npotentially\tO\nlimits\tO\ngeneralizability\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nAspirin\tB-Chemical\nreduces\tO\nthe\tO\nrisk\tO\nfor\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nmen\tO\nand\tO\nstrokes\tB-Disease\nin\tO\nwomen\tO\n.\tO\n\nAspirin\tB-Chemical\nuse\tO\nincreases\tO\nthe\tO\nrisk\tO\nfor\tO\nserious\tO\nbleeding\tB-Disease\nevents\tO\n.\tO\n\nReducing\tO\nharm\tO\nassociated\tO\nwith\tO\nanticoagulation\tO\n:\tO\npractical\tO\nconsiderations\tO\nof\tO\nargatroban\tB-Chemical\ntherapy\tO\nin\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n.\tO\n\nArgatroban\tB-Chemical\nis\tO\na\tO\nhepatically\tO\nmetabolized\tO\n,\tO\ndirect\tO\nthrombin\tO\ninhibitor\tO\nused\tO\nfor\tO\nprophylaxis\tO\nor\tO\ntreatment\tO\nof\tO\nthrombosis\tB-Disease\nin\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n(\tO\nHIT\tB-Disease\n)\tO\nand\tO\nfor\tO\npatients\tO\nwith\tO\nor\tO\nat\tO\nrisk\tO\nof\tO\nHIT\tB-Disease\nundergoing\tO\npercutaneous\tO\ncoronary\tO\nintervention\tO\n(\tO\nPCI\tO\n)\tO\n.\tO\n\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nreview\tO\nis\tO\nto\tO\nsummarize\tO\npractical\tO\nconsiderations\tO\nof\tO\nargatroban\tB-Chemical\ntherapy\tO\nin\tO\nHIT\tB-Disease\n.\tO\n\nThe\tO\nUS\tO\nFDA\tO\n-\tO\nrecommended\tO\nargatroban\tB-Chemical\ndose\tO\nin\tO\nHIT\tB-Disease\nis\tO\n2\tO\nmicrog\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n(\tO\nreduced\tO\nin\tO\npatients\tO\nwith\tO\nhepatic\tB-Disease\nimpairment\tI-Disease\nand\tO\nin\tO\npaediatric\tO\npatients\tO\n)\tO\n,\tO\nadjusted\tO\nto\tO\nachieve\tO\nactivated\tO\npartial\tO\nthromboplastin\tO\ntimes\tO\n(\tO\naPTTs\tO\n)\tO\n1\tO\n.\tO\n5\tO\n-\tO\n3\tO\ntimes\tO\nbaseline\tO\n(\tO\nnot\tO\n>\tO\n100\tO\nseconds\tO\n)\tO\n.\tO\n\nContemporary\tO\nexperiences\tO\nindicate\tO\nthat\tO\nreduced\tO\ndoses\tO\nare\tO\nalso\tO\nneeded\tO\nin\tO\npatients\tO\nwith\tO\nconditions\tO\nassociated\tO\nwith\tO\nhepatic\tO\nhypoperfusion\tO\n,\tO\ne\tO\n.\tO\ng\tO\n.\tO\nheart\tB-Disease\nfailure\tI-Disease\n,\tO\nyet\tO\nare\tO\nunnecessary\tO\nfor\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\n,\tO\nadult\tO\nage\tO\n,\tO\nsex\tO\n,\tO\nrace\tO\n/\tO\nethnicity\tO\nor\tO\nobesity\tB-Disease\n.\tO\n\nArgatroban\tB-Chemical\n0\tO\n.\tO\n5\tO\n-\tO\n1\tO\n.\tO\n2\tO\nmicrog\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\ntypically\tO\nsupports\tO\ntherapeutic\tO\naPTTs\tO\n.\tO\n\nThe\tO\nFDA\tO\n-\tO\nrecommended\tO\ndose\tO\nduring\tO\nPCI\tO\nis\tO\n25\tO\nmicrog\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n(\tO\n350\tO\nmicrog\tO\n/\tO\nkg\tO\ninitial\tO\nbolus\tO\n)\tO\n,\tO\nadjusted\tO\nto\tO\nachieve\tO\nactivated\tO\nclotting\tO\ntimes\tO\n(\tO\nACTs\tO\n)\tO\nof\tO\n300\tO\n-\tO\n450\tO\nsec\tO\n.\tO\n\nFor\tO\nPCI\tO\n,\tO\nargatroban\tB-Chemical\nhas\tO\nnot\tO\nbeen\tO\ninvestigated\tO\nin\tO\nhepatically\tO\nimpaired\tO\npatients\tO\n;\tO\ndose\tO\nadjustment\tO\nis\tO\nunnecessary\tO\nfor\tO\nadult\tO\nage\tO\n,\tO\nsex\tO\n,\tO\nrace\tO\n/\tO\nethnicity\tO\nor\tO\nobesity\tB-Disease\n,\tO\nand\tO\nlesser\tO\ndoses\tO\nmay\tO\nbe\tO\nadequate\tO\nwith\tO\nconcurrent\tO\nglycoprotein\tO\nIIb\tO\n/\tO\nIIIa\tO\ninhibition\tO\n.\tO\n\nArgatroban\tB-Chemical\nprolongs\tO\nthe\tO\nInternational\tO\nNormalized\tO\nRatio\tO\n,\tO\nand\tO\npublished\tO\napproaches\tO\nfor\tO\nmonitoring\tO\nthe\tO\nargatroban\tB-Chemical\n-\tO\nto\tO\n-\tO\nwarfarin\tB-Chemical\ntransition\tO\nshould\tO\nbe\tO\nfollowed\tO\n.\tO\n\nMajor\tO\nbleeding\tB-Disease\nwith\tO\nargatroban\tB-Chemical\nis\tO\n0\tO\n-\tO\n10\tO\n%\tO\nin\tO\nthe\tO\nnon\tO\n-\tO\ninterventional\tO\nsetting\tO\nand\tO\n0\tO\n-\tO\n5\tO\n.\tO\n8\tO\n%\tO\nperiprocedurally\tO\n.\tO\n\nArgatroban\tB-Chemical\nhas\tO\nno\tO\nspecific\tO\nantidote\tO\n,\tO\nand\tO\nif\tO\nexcessive\tO\nanticoagulation\tO\noccurs\tO\n,\tO\nargatroban\tB-Chemical\ninfusion\tO\nshould\tO\nbe\tO\nstopped\tO\nor\tO\nreduced\tO\n.\tO\n\nImproved\tO\nfamiliarity\tO\nof\tO\nhealthcare\tO\nprofessionals\tO\nwith\tO\nargatroban\tB-Chemical\ntherapy\tO\nin\tO\nHIT\tB-Disease\n,\tO\nincluding\tO\nin\tO\nspecial\tO\npopulations\tO\nand\tO\nduring\tO\nPCI\tO\n,\tO\nmay\tO\nfacilitate\tO\nreduction\tO\nof\tO\nharm\tO\nassociated\tO\nwith\tO\nHIT\tB-Disease\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\nfewer\tO\nthromboses\tO\n)\tO\nor\tO\nits\tO\ntreatment\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\nfewer\tO\nargatroban\tB-Chemical\nmedication\tO\nerrors\tO\n)\tO\n.\tO\n\nRhabdomyolysis\tB-Disease\nand\tO\nbrain\tO\nischemic\tB-Disease\nstroke\tI-Disease\nin\tO\na\tO\nheroin\tB-Chemical\n-\tO\ndependent\tO\nmale\tO\nunder\tO\nmethadone\tB-Chemical\nmaintenance\tO\ntherapy\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThere\tO\nare\tO\nseveral\tO\ncomplications\tO\nassociated\tO\nwith\tO\nheroin\tB-Disease\nabuse\tI-Disease\n,\tO\nsome\tO\nof\tO\nwhich\tO\nare\tO\nlife\tO\n-\tO\nthreatening\tO\n.\tO\n\nMethadone\tB-Chemical\nmay\tO\naggravate\tO\nthis\tO\nproblem\tO\n.\tO\n\nMETHOD\tO\n:\tO\nA\tO\nclinical\tO\ncase\tO\ndescription\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\n33\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\npresented\tO\nwith\tO\nrhabdomyolysis\tB-Disease\nand\tO\ncerebral\tO\nischemic\tB-Disease\nstroke\tI-Disease\nafter\tO\nintravenous\tO\nheroin\tB-Chemical\n.\tO\n\nHe\tO\nhad\tO\nused\tO\nheroin\tB-Chemical\nsince\tO\nage\tO\n20\tO\n,\tO\nand\tO\nhad\tO\nused\tO\n150\tO\nmg\tO\nmethadone\tB-Chemical\ndaily\tO\nfor\tO\n6\tO\nmonths\tO\n.\tO\n\nHe\tO\nwas\tO\nfound\tO\nunconsciousness\tB-Disease\nat\tO\nhome\tO\nand\tO\nwas\tO\nsent\tO\nto\tO\nour\tO\nhospital\tO\n.\tO\n\nIn\tO\nthe\tO\nER\tO\n,\tO\nhis\tO\nopiate\tO\nlevel\tO\nwas\tO\n4497\tO\nng\tO\n/\tO\nml\tO\n.\tO\n\nIn\tO\nthe\tO\nICU\tO\n,\tO\nwe\tO\nfound\tO\nrhabdomyolysis\tB-Disease\n,\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nand\tO\nacute\tO\nrespiratory\tB-Disease\nfailure\tI-Disease\n.\tO\n\nAfter\tO\ntransfer\tO\nto\tO\nan\tO\ninternal\tO\nward\tO\n,\tO\nwe\tO\nnoted\tO\naphasia\tB-Disease\nand\tO\nweakness\tB-Disease\nof\tO\nhis\tO\nleft\tO\nlimbs\tO\n.\tO\n\nAfter\tO\nMRI\tO\n,\tO\nwe\tO\nfound\tO\ncerebral\tB-Disease\nischemic\tI-Disease\ninfarction\tI-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nThose\tO\nusing\tO\nmethadone\tB-Chemical\nand\tO\nheroin\tB-Chemical\nsimultaneously\tO\nmay\tO\nincrease\tO\nrisk\tO\nof\tO\nrhabdomyolysis\tB-Disease\nand\tO\nischemic\tB-Disease\nstroke\tI-Disease\n.\tO\n\nPatients\tO\nunder\tO\nmethadone\tB-Chemical\nmaintenance\tO\ntherapy\tO\nshould\tO\nbe\tO\nwarned\tO\nregarding\tO\nthese\tO\nserious\tO\nadverse\tO\nevents\tO\n.\tO\n\nHypotheses\tO\nof\tO\nheroin\tB-Chemical\n-\tO\nrelated\tO\nrhabdomyolysis\tB-Disease\nand\tO\nstroke\tB-Disease\nin\tO\nheroin\tB-Chemical\nabusers\tO\nare\tO\ndiscussed\tO\n.\tO\n\nIncreased\tO\nvulnerability\tO\nto\tO\n6\tB-Chemical\n-\tI-Chemical\nhydroxydopamine\tI-Chemical\nlesion\tO\nand\tO\nreduced\tO\ndevelopment\tO\nof\tO\ndyskinesias\tB-Disease\nin\tO\nmice\tO\nlacking\tO\nCB1\tO\ncannabinoid\tO\nreceptors\tO\n.\tO\n\nMotor\tO\nimpairment\tO\n,\tO\ndopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\nneuronal\tO\nactivity\tO\nand\tO\nproenkephalin\tB-Chemical\n(\tO\nPENK\tB-Chemical\n)\tO\ngene\tO\nexpression\tO\nin\tO\nthe\tO\ncaudate\tO\n-\tO\nputamen\tO\n(\tO\nCPu\tO\n)\tO\nwere\tO\nmeasured\tO\nin\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\n-\tO\nlesioned\tO\nand\tO\ntreated\tO\n(\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n+\tI-Chemical\nbenserazide\tI-Chemical\n)\tO\nCB1\tO\nKO\tO\nand\tO\nWT\tO\nmice\tO\n.\tO\n\nA\tO\nlesion\tO\ninduced\tO\nby\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\nproduced\tO\nmore\tO\nsevere\tO\nmotor\tO\ndeterioration\tO\nin\tO\nCB1\tO\nKO\tO\nmice\tO\naccompanied\tO\nby\tO\nmore\tO\nloss\tO\nof\tO\nDA\tB-Chemical\nneurons\tO\nand\tO\nincreased\tO\nPENK\tB-Chemical\ngene\tO\nexpression\tO\nin\tO\nthe\tO\nCPu\tO\n.\tO\n\nOxidative\tO\n/\tO\nnitrosative\tO\nand\tO\nneuroinflammatory\tO\nparameters\tO\nwere\tO\nestimated\tO\nin\tO\nthe\tO\nCPu\tO\nand\tO\ncingulate\tO\ncortex\tO\n(\tO\nCg\tO\n)\tO\n.\tO\n\nCB1\tO\nKO\tO\nmice\tO\nexhibited\tO\nhigher\tO\nMDA\tB-Chemical\nlevels\tO\nand\tO\niNOS\tO\nprotein\tO\nexpression\tO\nin\tO\nthe\tO\nCPu\tO\nand\tO\nCg\tO\ncompared\tO\nto\tO\nWT\tO\nmice\tO\n.\tO\n\nTreatment\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n+\tI-Chemical\nbenserazide\tI-Chemical\n(\tO\n12\tO\nweeks\tO\n)\tO\nresulted\tO\nin\tO\nless\tO\nsevere\tO\ndyskinesias\tB-Disease\nin\tO\nCB1\tO\nKO\tO\nthan\tO\nin\tO\nWT\tO\nmice\tO\n.\tO\n\nThe\tO\nresults\tO\nrevealed\tO\nthat\tO\nthe\tO\nlack\tO\nof\tO\ncannabinoid\tO\nCB1\tO\nreceptors\tO\nincreased\tO\nthe\tO\nseverity\tO\nof\tO\nmotor\tO\nimpairment\tO\nand\tO\nDA\tB-Chemical\nlesion\tO\n,\tO\nand\tO\nreduced\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nactivation\tO\nof\tO\nCB1\tO\nreceptors\tO\noffers\tO\nneuroprotection\tO\nagainst\tO\ndopaminergic\tO\nlesion\tO\nand\tO\nthe\tO\ndevelopment\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n.\tO\n\nHepatocellular\tO\noxidant\tO\nstress\tO\nfollowing\tO\nintestinal\tO\nischemia\tB-Disease\n-\tO\nreperfusion\tB-Disease\ninjury\tI-Disease\n.\tO\n\nReperfusion\tO\nof\tO\nischemic\tB-Disease\nintestine\tO\nresults\tO\nin\tO\nacute\tO\nliver\tB-Disease\ndysfunction\tI-Disease\ncharacterized\tO\nby\tO\nhepatocellular\tO\nenzyme\tO\nrelease\tO\ninto\tO\nplasma\tO\n,\tO\nreduction\tO\nin\tO\nbile\tO\nflow\tO\nrate\tO\n,\tO\nand\tO\nneutrophil\tO\nsequestration\tO\nwithin\tO\nthe\tO\nliver\tO\n.\tO\n\nThe\tO\npathophysiology\tO\nunderlying\tO\nthis\tO\nacute\tO\nhepatic\tB-Disease\ninjury\tI-Disease\nis\tO\nunknown\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ndetermine\tO\nwhether\tO\noxidants\tO\nare\tO\nassociated\tO\nwith\tO\nthe\tO\nhepatic\tB-Disease\ninjury\tI-Disease\nand\tO\nto\tO\ndetermine\tO\nthe\tO\nrelative\tO\nvalue\tO\nof\tO\nseveral\tO\nindirect\tO\nmethods\tO\nof\tO\nassessing\tO\noxidant\tO\nexposure\tO\nin\tO\nvivo\tO\n.\tO\n\nRats\tO\nwere\tO\nsubjected\tO\nto\tO\na\tO\nstandardized\tO\nintestinal\tO\nischemia\tB-Disease\n-\tO\nreperfusion\tB-Disease\ninjury\tI-Disease\n.\tO\n\nHepatic\tO\ntissue\tO\nwas\tO\nassayed\tO\nfor\tO\nlipid\tO\nperoxidation\tO\nproducts\tO\nand\tO\noxidized\tB-Chemical\nand\tI-Chemical\nreduced\tI-Chemical\nglutathione\tI-Chemical\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nchange\tO\nin\tO\nhepatic\tO\ntissue\tO\ntotal\tO\nglutathione\tB-Chemical\nfollowing\tO\nintestinal\tO\nischemia\tB-Disease\n-\tO\nreperfusion\tB-Disease\ninjury\tI-Disease\n.\tO\n\nOxidized\tB-Chemical\nglutathione\tI-Chemical\n(\tO\nGSSG\tB-Chemical\n)\tO\nincreased\tO\nsignificantly\tO\nfollowing\tO\n30\tO\nand\tO\n60\tO\nmin\tO\nof\tO\nreperfusion\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nincrease\tO\nin\tO\nany\tO\nof\tO\nthe\tO\nproducts\tO\nof\tO\nlipid\tO\nperoxidation\tO\nassociated\tO\nwith\tO\nthis\tO\ninjury\tO\n.\tO\n\nAn\tO\nincrease\tO\nin\tO\nGSSG\tB-Chemical\nwithin\tO\nhepatic\tO\ntissue\tO\nduring\tO\nintestinal\tO\nreperfusion\tO\nsuggests\tO\nexposure\tO\nof\tO\nhepatocytes\tO\nto\tO\nan\tO\noxidant\tO\nstress\tO\n.\tO\n\nThe\tO\nlack\tO\nof\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nproducts\tO\nof\tO\nlipid\tO\nperoxidation\tO\nsuggests\tO\nthat\tO\nthe\tO\noxidant\tO\nstress\tO\nis\tO\nof\tO\ninsufficient\tO\nmagnitude\tO\nto\tO\nresult\tO\nin\tO\nirreversible\tO\ninjury\tO\nto\tO\nhepatocyte\tO\ncell\tO\nmembranes\tO\n.\tO\n\nThese\tO\ndata\tO\nalso\tO\nsuggest\tO\nthat\tO\nthe\tO\nmeasurement\tO\nof\tO\ntissue\tO\nGSSG\tB-Chemical\nmay\tO\nbe\tO\na\tO\nmore\tO\nsensitive\tO\nindicator\tO\nof\tO\noxidant\tO\nstress\tO\nthan\tO\nmeasurement\tO\nof\tO\nproducts\tO\nof\tO\nlipid\tO\nperoxidation\tO\n.\tO\n\nAnimal\tO\nmodel\tO\nof\tO\nmania\tB-Disease\ninduced\tO\nby\tO\nouabain\tB-Chemical\n:\tO\nEvidence\tO\nof\tO\noxidative\tO\nstress\tO\nin\tO\nsubmitochondrial\tO\nparticles\tO\nof\tO\nthe\tO\nrat\tO\nbrain\tO\n.\tO\n\nThe\tO\nintracerebroventricular\tO\n(\tO\nICV\tO\n)\tO\nadministration\tO\nof\tO\nouabain\tB-Chemical\n(\tO\na\tO\nNa\tB-Chemical\n(\tO\n+\tO\n)\tO\n/\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nATPase\tO\ninhibitor\tO\n)\tO\nin\tO\nrats\tO\nhas\tO\nbeen\tO\nsuggested\tO\nto\tO\nmimic\tO\nsome\tO\nsymptoms\tO\nof\tO\nhuman\tO\nbipolar\tB-Disease\nmania\tI-Disease\n.\tO\n\nClinical\tO\nstudies\tO\nhave\tO\nshown\tO\nthat\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nmitochondrial\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nHerein\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\nbehavioral\tO\nand\tO\nbiochemical\tO\neffects\tO\ninduced\tO\nby\tO\nthe\tO\nICV\tO\nadministration\tO\nof\tO\nouabain\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nTo\tO\nachieve\tO\nthis\tO\naim\tO\n,\tO\nthe\tO\neffects\tO\nof\tO\nouabain\tB-Chemical\ninjection\tO\nimmediately\tO\nafter\tO\nand\tO\n7\tO\ndays\tO\nfollowing\tO\na\tO\nsingle\tO\nICV\tO\nadministration\tO\n(\tO\nat\tO\nconcentrations\tO\nof\tO\n10\tO\n(\tO\n-\tO\n2\tO\n)\tO\nand\tO\n10\tO\n(\tO\n-\tO\n3\tO\n)\tO\nM\tO\n)\tO\non\tO\nlocomotion\tO\nwas\tO\nmeasured\tO\nusing\tO\nthe\tO\nopen\tO\n-\tO\nfield\tO\ntest\tO\n.\tO\n\nAdditionally\tO\n,\tO\nthiobarbituric\tB-Chemical\nacid\tI-Chemical\nreactive\tO\nsubstances\tO\n(\tO\nTBARSs\tO\n)\tO\nand\tO\nsuperoxide\tB-Chemical\nproduction\tO\nwere\tO\nmeasured\tO\nin\tO\nsubmitochondrial\tO\nparticles\tO\nof\tO\nthe\tO\nprefrontal\tO\ncortex\tO\n,\tO\nhippocampus\tO\n,\tO\nstriatum\tO\nand\tO\namygdala\tO\n.\tO\n\nOur\tO\nfindings\tO\ndemonstrated\tO\nthat\tO\nouabain\tB-Chemical\nat\tO\n10\tO\n(\tO\n-\tO\n2\tO\n)\tO\nand\tO\n10\tO\n(\tO\n-\tO\n3\tO\n)\tO\nM\tO\ninduced\tO\nhyperlocomotion\tB-Disease\nin\tO\nrats\tO\n,\tO\nand\tO\nthis\tO\nresponse\tO\nremained\tO\nup\tO\nto\tO\n7\tO\ndays\tO\nfollowing\tO\na\tO\nsingle\tO\nICV\tO\ninjection\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nwe\tO\nobserved\tO\nthat\tO\nthe\tO\npersistent\tO\nincrease\tO\nin\tO\nthe\tO\nrat\tO\nspontaneous\tO\nlocomotion\tO\nis\tO\nassociated\tO\nwith\tO\nincreased\tO\nTBARS\tO\nlevels\tO\nand\tO\nsuperoxide\tB-Chemical\ngeneration\tO\nin\tO\nsubmitochondrial\tO\nparticles\tO\nin\tO\nthe\tO\nprefrontal\tO\ncortex\tO\n,\tO\nstriatum\tO\nand\tO\namygdala\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nouabain\tB-Chemical\n-\tO\ninduced\tO\nmania\tB-Disease\n-\tO\nlike\tO\nbehavior\tO\nmay\tO\nprovide\tO\na\tO\nuseful\tO\nanimal\tO\nmodel\tO\nto\tO\ntest\tO\nthe\tO\nhypothesis\tO\nof\tO\nthe\tO\ninvolvement\tO\nof\tO\noxidative\tO\nstress\tO\nin\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nIntraoperative\tO\ndialysis\tO\nduring\tO\nliver\tO\ntransplantation\tO\nwith\tO\ncitrate\tB-Chemical\ndialysate\tO\n.\tO\n\nLiver\tO\ntransplantation\tO\nfor\tO\nacutely\tO\nill\tO\npatients\tO\nwith\tO\nfulminant\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\ncarries\tO\nhigh\tO\nintraoperative\tO\nand\tO\nimmediate\tO\npostoperative\tO\nrisks\tO\n.\tO\n\nThese\tO\nare\tO\nincreased\tO\nwith\tO\nthe\tO\npresence\tO\nof\tO\nconcomitant\tO\nacute\tB-Disease\nkidney\tI-Disease\ninjury\tI-Disease\n(\tO\nAKI\tB-Disease\n)\tO\nand\tO\nintraoperative\tO\ndialysis\tO\nis\tO\nsometimes\tO\nrequired\tO\nto\tO\nallow\tO\nthe\tO\ntransplant\tO\nto\tO\nproceed\tO\n.\tO\n\nThe\tO\nderangements\tO\nin\tO\nthe\tO\nprocoagulant\tO\nand\tO\nanticoagulant\tO\npathways\tO\nduring\tO\nfulminant\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\ncan\tO\nlead\tO\nto\tO\ndifficulties\tO\nwith\tO\nanticoagulation\tO\nduring\tO\ndialysis\tO\n,\tO\nespecially\tO\nwhen\tO\ncontinued\tO\nin\tO\nthe\tO\noperating\tO\nroom\tO\n.\tO\n\nSystemic\tO\nanticoagulation\tO\nis\tO\nunsafe\tO\nand\tO\nregional\tO\ncitrate\tB-Chemical\nanticoagulation\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\na\tO\nfunctional\tO\nliver\tO\ncarries\tO\nthe\tO\nrisk\tO\nof\tO\ncitrate\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nCitrate\tB-Chemical\ndialysate\tO\n,\tO\na\tO\nnew\tO\ndialysate\tO\nwith\tO\ncitric\tB-Chemical\nacid\tI-Chemical\ncan\tO\nbe\tO\nused\tO\nfor\tO\nanticoagulation\tO\nin\tO\npatients\tO\nwho\tO\ncannot\tO\ntolerate\tO\nheparin\tB-Chemical\nor\tO\nregional\tO\ncitrate\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\n40\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfemale\tO\nwith\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nfulminant\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nwith\tO\nassociated\tO\nAKI\tB-Disease\nwho\tO\nunderwent\tO\nintraoperative\tO\ndialytic\tO\nsupport\tO\nduring\tO\nliver\tO\ntransplantation\tO\nanticoagulated\tO\nwith\tO\ncitrate\tB-Chemical\ndialysate\tO\nduring\tO\nthe\tO\nentire\tO\nprocedure\tO\n.\tO\n\nThe\tO\npatient\tO\ntolerated\tO\nthe\tO\nprocedure\tO\nwell\tO\nwithout\tO\nany\tO\nsigns\tO\nof\tO\ncitrate\tB-Chemical\ntoxicity\tB-Disease\nand\tO\nmaintained\tO\nadequate\tO\nanticoagulation\tO\nfor\tO\npatency\tO\nof\tO\nthe\tO\ndialysis\tO\ncircuit\tO\n.\tO\n\nCitrate\tB-Chemical\ndialysate\tO\nis\tO\na\tO\nsafe\tO\nalternative\tO\nfor\tO\nintradialytic\tO\nsupport\tO\nof\tO\nliver\tO\ntransplantation\tO\nin\tO\nfulminant\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n.\tO\n\nDelirium\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\ntoxic\tO\nflecainide\tB-Chemical\nplasma\tO\nconcentrations\tO\n:\tO\nthe\tO\nrole\tO\nof\tO\na\tO\npharmacokinetic\tO\ndrug\tO\ninteraction\tO\nwith\tO\nparoxetine\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\nflecainide\tB-Chemical\n-\tO\ninduced\tO\ndelirium\tB-Disease\nassociated\tO\nwith\tO\na\tO\npharmacokinetic\tO\ndrug\tO\ninteraction\tO\nwith\tO\nparoxetine\tB-Chemical\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n69\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwhite\tO\nfemale\tO\npresented\tO\nto\tO\nthe\tO\nemergency\tO\ndepartment\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nconfusion\tB-Disease\nand\tO\nparanoia\tB-Disease\nover\tO\nthe\tO\npast\tO\nseveral\tO\ndays\tO\n.\tO\n\nOn\tO\nadmission\tO\nthe\tO\npatient\tO\nwas\tO\ntaking\tO\ncarvedilol\tB-Chemical\n12\tO\nmg\tO\ntwice\tO\ndaily\tO\n,\tO\nwarfarin\tB-Chemical\n2\tO\nmg\tO\n/\tO\nday\tO\n,\tO\nfolic\tB-Chemical\nacid\tI-Chemical\n1\tO\nmg\tO\n/\tO\nday\tO\n,\tO\nlevothyroxine\tB-Chemical\n100\tO\nmicrog\tO\n/\tO\nday\tO\n,\tO\npantoprazole\tB-Chemical\n40\tO\nmg\tO\n/\tO\nday\tO\n,\tO\nparoxetine\tB-Chemical\n40\tO\nmg\tO\n/\tO\nday\tO\n,\tO\nand\tO\nflecainide\tB-Chemical\n100\tO\nmg\tO\ntwice\tO\ndaily\tO\n.\tO\n\nFlecainide\tB-Chemical\nhad\tO\nbeen\tO\nstarted\tO\n2\tO\nweeks\tO\nprior\tO\nfor\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n.\tO\n\nLaboratory\tO\ntest\tO\nfindings\tO\non\tO\nadmission\tO\nwere\tO\nnotable\tO\nonly\tO\nfor\tO\na\tO\nflecainide\tB-Chemical\nplasma\tO\nconcentration\tO\nof\tO\n1360\tO\nmicrog\tO\n/\tO\nL\tO\n(\tO\nreference\tO\nrange\tO\n200\tO\n-\tO\n1000\tO\n)\tO\n.\tO\n\nA\tO\nmetabolic\tO\ndrug\tO\ninteraction\tO\nbetween\tO\nflecainide\tB-Chemical\nand\tO\nparoxetine\tB-Chemical\n,\tO\nwhich\tO\nthe\tO\npatient\tO\nhad\tO\nbeen\tO\ntaking\tO\nfor\tO\nmore\tO\nthan\tO\n5\tO\nyears\tO\n,\tO\nwas\tO\nconsidered\tO\n.\tO\n\nParoxetine\tB-Chemical\nwas\tO\ndiscontinued\tO\nand\tO\nthe\tO\ndose\tO\nof\tO\nflecainide\tB-Chemical\nwas\tO\nreduced\tO\nto\tO\n50\tO\nmg\tO\ntwice\tO\ndaily\tO\n.\tO\n\nHer\tO\ndelirium\tB-Disease\nresolved\tO\n3\tO\ndays\tO\nlater\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nFlecainide\tB-Chemical\nand\tO\npharmacologically\tO\nsimilar\tO\nagents\tO\nthat\tO\ninteract\tO\nwith\tO\nsodium\tB-Chemical\nchannels\tO\nmay\tO\ncause\tO\ndelirium\tB-Disease\nin\tO\nsusceptible\tO\npatients\tO\n.\tO\n\nA\tO\nMEDLINE\tO\nsearch\tO\n(\tO\n1966\tO\n-\tO\nJanuary\tO\n2009\tO\n)\tO\nrevealed\tO\none\tO\nin\tO\nvivo\tO\npharmacokinetic\tO\nstudy\tO\non\tO\nthe\tO\ninteraction\tO\nbetween\tO\nflecainide\tB-Chemical\n,\tO\na\tO\nCYP2D6\tO\nsubstrate\tO\n,\tO\nand\tO\nparoxetine\tB-Chemical\n,\tO\na\tO\nCYP2D6\tO\ninhibitor\tO\n,\tO\nas\tO\nwell\tO\nas\tO\n3\tO\ncase\tO\nreports\tO\nof\tO\nflecainide\tB-Chemical\n-\tO\ninduced\tO\ndelirium\tB-Disease\n.\tO\n\nAccording\tO\nto\tO\nthe\tO\nNaranjo\tO\nprobability\tO\nscale\tO\n,\tO\nflecainide\tB-Chemical\nwas\tO\nthe\tO\nprobable\tO\ncause\tO\nof\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\ndelirium\tB-Disease\n;\tO\nthe\tO\nHorn\tO\nDrug\tO\nInteraction\tO\nProbability\tO\nScale\tO\nindicates\tO\na\tO\npossible\tO\npharmacokinetic\tO\ndrug\tO\ninteraction\tO\nbetween\tO\nflecainide\tB-Chemical\nand\tO\nparoxetine\tB-Chemical\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSupratherapeutic\tO\nflecainide\tB-Chemical\nplasma\tO\nconcentrations\tO\nmay\tO\ncause\tO\ndelirium\tB-Disease\n.\tO\n\nBecause\tO\ntoxicity\tB-Disease\nmay\tO\noccur\tO\nwhen\tO\nflecainide\tB-Chemical\nis\tO\nprescribed\tO\nwith\tO\nparoxetine\tB-Chemical\nand\tO\nother\tO\npotent\tO\nCYP2D6\tO\ninhibitors\tO\n,\tO\nflecainide\tB-Chemical\nplasma\tO\nconcentrations\tO\nshould\tO\nbe\tO\nmonitored\tO\nclosely\tO\nwith\tO\ncommencement\tO\nof\tO\nCYP2D6\tO\ninhibitors\tO\n.\tO\n\nEfficacy\tO\nof\tO\neverolimus\tB-Chemical\n(\tO\nRAD001\tB-Chemical\n)\tO\nin\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tB-Disease\npreviously\tO\ntreated\tO\nwith\tO\nchemotherapy\tO\nalone\tO\nor\tO\nwith\tO\nchemotherapy\tO\nand\tO\nEGFR\tO\ninhibitors\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nTreatment\tO\noptions\tO\nare\tO\nscarce\tO\nin\tO\npretreated\tO\nadvanced\tO\nnon\tB-Disease\n-\tI-Disease\nsmall\tI-Disease\n-\tI-Disease\ncell\tI-Disease\nlung\tI-Disease\ncancer\tI-Disease\n(\tO\nNSCLC\tB-Disease\n)\tO\npatients\tO\n.\tO\n\nRAD001\tB-Chemical\n,\tO\nan\tO\noral\tO\ninhibitor\tO\nof\tO\nthe\tO\nmammalian\tO\ntarget\tO\nof\tO\nrapamycin\tB-Chemical\n(\tO\nmTOR\tO\n)\tO\n,\tO\nhas\tO\nshown\tO\nphase\tO\nI\tO\nefficacy\tO\nin\tO\nNSCLC\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nStage\tO\nIIIb\tO\nor\tO\nIV\tO\nNSCLC\tB-Disease\npatients\tO\n,\tO\nwith\tO\ntwo\tO\nor\tO\nfewer\tO\nprior\tO\nchemotherapy\tO\nregimens\tO\n,\tO\none\tO\nplatinum\tB-Chemical\nbased\tO\n(\tO\nstratum\tO\n1\tO\n)\tO\nor\tO\nboth\tO\nchemotherapy\tO\nand\tO\nepidermal\tO\ngrowth\tO\nfactor\tO\nreceptor\tO\ntyrosine\tB-Chemical\nkinase\tO\ninhibitors\tO\n(\tO\nstratum\tO\n2\tO\n)\tO\n,\tO\nreceived\tO\nRAD001\tB-Chemical\n10\tO\nmg\tO\n/\tO\nday\tO\nuntil\tO\nprogression\tO\nor\tO\nunacceptable\tO\ntoxicity\tB-Disease\n.\tO\n\nPrimary\tO\nobjective\tO\nwas\tO\noverall\tO\nresponse\tO\nrate\tO\n(\tO\nORR\tO\n)\tO\n.\tO\n\nAnalyses\tO\nof\tO\nmarkers\tO\nassociated\tO\nwith\tO\nthe\tO\nmTOR\tO\npathway\tO\nwere\tO\ncarried\tO\nout\tO\non\tO\narchival\tO\ntumor\tB-Disease\nfrom\tO\na\tO\nsubgroup\tO\nusing\tO\nimmunohistochemistry\tO\n(\tO\nIHC\tO\n)\tO\nand\tO\ndirect\tO\nmutation\tO\nsequencing\tO\n.\tO\n\nRESULTS\tO\n:\tO\nEighty\tO\n-\tO\nfive\tO\npatients\tO\nwere\tO\nenrolled\tO\n,\tO\n42\tO\nin\tO\nstratum\tO\n1\tO\nand\tO\n43\tO\nin\tO\nstratum\tO\n.\tO\n\nORR\tO\nwas\tO\n4\tO\n.\tO\n7\tO\n%\tO\n(\tO\n7\tO\n.\tO\n1\tO\n%\tO\nstratum\tO\n1\tO\n;\tO\n2\tO\n.\tO\n3\tO\n%\tO\nstratum\tO\n2\tO\n)\tO\n.\tO\n\nOverall\tO\ndisease\tO\ncontrol\tO\nrate\tO\nwas\tO\n47\tO\n.\tO\n1\tO\n%\tO\n.\tO\n\nMedian\tO\nprogression\tO\n-\tO\nfree\tO\nsurvivals\tO\n(\tO\nPFSs\tO\n)\tO\nwere\tO\n2\tO\n.\tO\n6\tO\n(\tO\nstratum\tO\n1\tO\n)\tO\nand\tO\n2\tO\n.\tO\n7\tO\nmonths\tO\n(\tO\nstratum\tO\n2\tO\n)\tO\n.\tO\n\nCommon\tO\n>\tO\nor\tO\n=\tO\ngrade\tO\n3\tO\nevents\tO\nwere\tO\nfatigue\tB-Disease\n,\tO\ndyspnea\tB-Disease\n,\tO\nstomatitis\tB-Disease\n,\tO\nanemia\tB-Disease\n,\tO\nand\tO\nthrombocytopenia\tB-Disease\n.\tO\n\nPneumonitis\tB-Disease\n,\tO\nprobably\tO\nor\tO\npossibly\tO\nrelated\tO\n,\tO\nmainly\tO\ngrade\tO\n1\tO\n/\tO\n2\tO\n,\tO\noccurred\tO\nin\tO\n25\tO\n%\tO\n.\tO\n\nCox\tO\nregression\tO\nanalysis\tO\nof\tO\nIHC\tO\nscores\tO\nfound\tO\nthat\tO\nonly\tO\nphospho\tO\nAKT\tO\n(\tO\npAKT\tO\n)\tO\nwas\tO\na\tO\nsignificant\tO\nindependent\tO\npredictor\tO\nof\tO\nworse\tO\nPFS\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nRAD001\tB-Chemical\n10\tO\nmg\tO\n/\tO\nday\tO\nwas\tO\nwell\tO\ntolerated\tO\n,\tO\nshowing\tO\nmodest\tO\nclinical\tO\nactivity\tO\nin\tO\npretreated\tO\nNSCLC\tB-Disease\n.\tO\n\nEvaluation\tO\nof\tO\nRAD001\tB-Chemical\nplus\tO\nstandard\tO\ntherapy\tO\nfor\tO\nmetastatic\tO\nNSCLC\tB-Disease\ncontinues\tO\n.\tO\n\nPosttransplant\tO\nanemia\tB-Disease\n:\tO\nthe\tO\nrole\tO\nof\tO\nsirolimus\tB-Chemical\n.\tO\n\nPosttransplant\tO\nanemia\tB-Disease\nis\tO\na\tO\ncommon\tO\nproblem\tO\nthat\tO\nmay\tO\nhinder\tO\npatients\tO\n'\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nIt\tO\noccurs\tO\nin\tO\n12\tO\nto\tO\n76\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nand\tO\nis\tO\nmost\tO\ncommon\tO\nin\tO\nthe\tO\nimmediate\tO\nposttransplant\tO\nperiod\tO\n.\tO\n\nA\tO\nvariety\tO\nof\tO\nfactors\tO\nhave\tO\nbeen\tO\nidentified\tO\nthat\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nposttransplant\tO\nanemia\tB-Disease\n,\tO\nof\tO\nwhich\tO\nthe\tO\nlevel\tO\nof\tO\nrenal\tO\nfunction\tO\nis\tO\nmost\tO\nimportant\tO\n.\tO\n\nSirolimus\tB-Chemical\n,\tO\na\tO\nmammalian\tO\ntarget\tO\nof\tO\nrapamycin\tB-Chemical\ninhibitor\tO\n,\tO\nhas\tO\nbeen\tO\nimplicated\tO\nas\tO\nplaying\tO\na\tO\nspecial\tO\nrole\tO\nin\tO\nposttransplant\tO\nanemia\tB-Disease\n.\tO\n\nThis\tO\nreview\tO\nconsiders\tO\nanemia\tB-Disease\nassociated\tO\nwith\tO\nsirolimus\tB-Chemical\n,\tO\nincluding\tO\nits\tO\npresentation\tO\n,\tO\nmechanisms\tO\n,\tO\nand\tO\nmanagement\tO\n.\tO\n\nCoronary\tO\ncomputerized\tO\ntomography\tO\nangiography\tO\nfor\tO\nrapid\tO\ndischarge\tO\nof\tO\nlow\tO\n-\tO\nrisk\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nMost\tO\npatients\tO\npresenting\tO\nto\tO\nemergency\tO\ndepartments\tO\n(\tO\nEDs\tO\n)\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\nare\tO\nadmitted\tO\nfor\tO\nat\tO\nleast\tO\n12\tO\nhours\tO\nand\tO\nreceive\tO\na\tO\n\"\tO\nrule\tO\nout\tO\nacute\tB-Disease\ncoronary\tI-Disease\nsyndrome\tI-Disease\n\"\tO\nprotocol\tO\n,\tO\noften\tO\nwith\tO\nnoninvasive\tO\ntesting\tO\nprior\tO\nto\tO\ndischarge\tO\n.\tO\n\nIn\tO\npatients\tO\nwithout\tO\ncocaine\tB-Chemical\nuse\tO\n,\tO\ncoronary\tO\ncomputerized\tO\ntomography\tO\nangiography\tO\n(\tO\nCTA\tO\n)\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nbe\tO\nuseful\tO\nfor\tO\nidentifying\tO\na\tO\ngroup\tO\nof\tO\npatients\tO\nat\tO\nlow\tO\nrisk\tO\nfor\tO\ncardiac\tO\nevents\tO\nwho\tO\ncan\tO\nbe\tO\nsafely\tO\ndischarged\tO\n.\tO\n\nIt\tO\nis\tO\nunclear\tO\nwhether\tO\na\tO\ncoronary\tO\nCTA\tO\nstrategy\tO\nwould\tO\nbe\tO\nefficacious\tO\nin\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\n,\tO\nas\tO\ncoronary\tB-Disease\nvasospasm\tI-Disease\nmay\tO\naccount\tO\nfor\tO\nsome\tO\nof\tO\nthe\tO\nischemia\tB-Disease\n.\tO\n\nWe\tO\nstudied\tO\nwhether\tO\na\tO\nnegative\tO\ncoronary\tO\nCTA\tO\nin\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\ncould\tO\nidentify\tO\na\tO\nsubset\tO\nsafe\tO\nfor\tO\ndischarge\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nprospectively\tO\nevaluated\tO\nthe\tO\nsafety\tO\nof\tO\ncoronary\tO\nCTA\tO\nfor\tO\nlow\tO\n-\tO\nrisk\tO\npatients\tO\nwho\tO\npresented\tO\nto\tO\nthe\tO\nED\tO\nwith\tO\ncocaineassociated\tO\nchest\tB-Disease\npain\tI-Disease\n(\tO\nself\tO\n-\tO\nreported\tO\nor\tO\npositive\tO\nurine\tO\ntest\tO\n)\tO\n.\tO\n\nConsecutive\tO\npatients\tO\nreceived\tO\neither\tO\nimmediate\tO\ncoronary\tO\nCTA\tO\nin\tO\nthe\tO\nED\tO\n(\tO\nwithout\tO\nserial\tO\nmarkers\tO\n)\tO\nor\tO\nunderwent\tO\ncoronary\tO\nCTA\tO\nafter\tO\na\tO\nbrief\tO\nobservation\tO\nperiod\tO\nwith\tO\nserial\tO\ncardiac\tO\nmarker\tO\nmeasurements\tO\n.\tO\n\nPatients\tO\nwith\tO\nnegative\tO\ncoronary\tO\nCTA\tO\n(\tO\nmaximal\tO\nstenosis\tB-Disease\nless\tO\nthan\tO\n50\tO\n%\tO\n)\tO\nwere\tO\ndischarged\tO\n.\tO\n\nThe\tO\nmain\tO\noutcome\tO\nwas\tO\n30\tO\n-\tO\nday\tO\ncardiovascular\tO\ndeath\tO\nor\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n59\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\nwere\tO\nevaluated\tO\n.\tO\n\nPatients\tO\nhad\tO\na\tO\nmean\tO\nage\tO\nof\tO\n45\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n6\tO\nyrs\tO\nand\tO\nwere\tO\n86\tO\n%\tO\nblack\tO\n,\tO\n66\tO\n%\tO\nmale\tO\n.\tO\n\nSeventy\tO\n-\tO\nnine\tO\npercent\tO\nhad\tO\na\tO\nnormal\tO\nor\tO\nnonspecific\tO\nECG\tO\nand\tO\n85\tO\n%\tO\nhad\tO\na\tO\nTIMI\tO\nscore\tO\n<\tO\n2\tO\n.\tO\n\nTwenty\tO\npatients\tO\nreceived\tO\ncoronary\tO\nCTA\tO\nimmediately\tO\nin\tO\nthe\tO\nED\tO\n,\tO\n18\tO\nof\tO\nwhom\tO\nwere\tO\ndischarged\tO\nfollowing\tO\nCTA\tO\n(\tO\n90\tO\n%\tO\n)\tO\n.\tO\n\nThirty\tO\n-\tO\nnine\tO\nreceived\tO\ncoronary\tO\nCTA\tO\nafter\tO\na\tO\nbrief\tO\nobservation\tO\nperiod\tO\n,\tO\nwith\tO\n37\tO\ndischarged\tO\nhome\tO\nfollowing\tO\nCTA\tO\n(\tO\n95\tO\n%\tO\n)\tO\n.\tO\n\nSix\tO\npatients\tO\nhad\tO\ncoronary\tB-Disease\nstenosis\tI-Disease\n>\tO\nor\tO\n=\tO\n50\tO\n%\tO\n.\tO\n\nDuring\tO\nthe\tO\n30\tO\n-\tO\nday\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n,\tO\nno\tO\npatients\tO\ndied\tO\nof\tO\na\tO\ncardiovascular\tO\nevent\tO\n(\tO\n0\tO\n%\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n0\tO\n-\tO\n6\tO\n.\tO\n1\tO\n%\tO\n)\tO\nand\tO\nno\tO\npatient\tO\nsustained\tO\na\tO\nnonfatal\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n(\tO\n0\tO\n%\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n0\tO\n-\tO\n6\tO\n.\tO\n1\tO\n%\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAlthough\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\ncan\tO\nresult\tO\nfrom\tO\ncoronary\tO\nvasoconstriction\tO\n,\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\nassociated\tO\nchest\tB-Disease\npain\tI-Disease\n,\tO\na\tO\nnon\tO\n-\tO\nischemic\tB-Disease\nECG\tO\n,\tO\nand\tO\na\tO\nTIMI\tO\nrisk\tO\nscore\tO\n<\tO\n2\tO\nmay\tO\nbe\tO\nsafely\tO\ndischarged\tO\nfrom\tO\nthe\tO\nED\tO\nafter\tO\na\tO\nnegative\tO\ncoronary\tO\nCTA\tO\nwith\tO\na\tO\nlow\tO\nrisk\tO\nof\tO\n30\tO\n-\tO\nday\tO\nadverse\tO\nevents\tO\n.\tO\n\nBilateral\tO\nhaemorrhagic\tB-Disease\ninfarction\tI-Disease\nof\tI-Disease\nthe\tI-Disease\nglobus\tI-Disease\npallidus\tI-Disease\nafter\tO\ncocaine\tB-Chemical\nand\tO\nalcohol\tB-Chemical\nintoxication\tO\n.\tO\n\nCocaine\tB-Chemical\nis\tO\na\tO\nrisk\tO\nfactor\tO\nfor\tO\nboth\tO\nischemic\tB-Disease\nand\tI-Disease\nhaemorrhagic\tI-Disease\nstroke\tI-Disease\n.\tO\n\nWe\tO\npresent\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n31\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nbilateral\tO\nischemia\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nglobus\tI-Disease\npallidus\tI-Disease\nafter\tO\nexcessive\tO\nalcohol\tB-Chemical\nand\tO\nintranasal\tO\ncocaine\tB-Chemical\nuse\tO\n.\tO\n\nDrug\tO\n-\tO\nrelated\tO\nglobus\tB-Disease\npallidus\tI-Disease\ninfarctions\tI-Disease\nare\tO\nmost\tO\noften\tO\nassociated\tO\nwith\tO\nheroin\tB-Chemical\n.\tO\n\nBilateral\tO\nbasal\tB-Disease\nganglia\tI-Disease\ninfarcts\tI-Disease\nafter\tO\nthe\tO\nuse\tO\nof\tO\ncocaine\tB-Chemical\n,\tO\nwithout\tO\nconcurrent\tO\nheroin\tB-Chemical\nuse\tO\n,\tO\nhave\tO\nnever\tO\nbeen\tO\nreported\tO\n.\tO\n\nIn\tO\nour\tO\npatient\tO\n,\tO\ntransient\tO\ncardiac\tB-Disease\narrhythmia\tI-Disease\nor\tO\nrespiratory\tB-Disease\ndysfunction\tI-Disease\nrelated\tO\nto\tO\ncocaine\tB-Chemical\nand\tO\n/\tO\nor\tO\nethanol\tB-Chemical\nuse\tO\nwere\tO\nthe\tO\nmost\tO\nlikely\tO\ncauses\tO\nof\tO\ncerebral\tB-Disease\nhypoperfusion\tI-Disease\n.\tO\n\nLate\tO\nfulminant\tO\nposterior\tB-Disease\nreversible\tI-Disease\nencephalopathy\tI-Disease\nsyndrome\tI-Disease\nafter\tO\nliver\tO\ntransplant\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nPosterior\tB-Disease\nleukoencephalopathy\tI-Disease\ndue\tO\nto\tO\ncalcineurin\tO\n-\tO\ninhibitor\tO\n-\tO\nrelated\tO\nneurotoxicity\tB-Disease\nis\tO\na\tO\nrare\tO\nbut\tO\nsevere\tO\ncomplication\tO\nthat\tO\nresults\tO\nfrom\tO\ntreatment\tO\nwith\tO\nimmunosuppressive\tO\nagents\tO\n(\tO\nprimarily\tO\nthose\tO\nadministered\tO\nafter\tO\na\tO\nliver\tO\nor\tO\nkidney\tO\ntransplant\tO\n)\tO\n.\tO\n\nThe\tO\npathophysiologic\tO\nmechanisms\tO\nof\tO\nthat\tO\ndisorder\tO\nremain\tO\nunknown\tO\n.\tO\n\nCASE\tO\n:\tO\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n46\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwho\tO\nreceived\tO\na\tO\nliver\tO\ntransplant\tO\nin\tO\nour\tO\ncenter\tO\nas\tO\ntreatment\tO\nfor\tO\nalcoholic\tB-Disease\ncirrhosis\tI-Disease\nand\tO\nin\tO\nwhom\tO\neither\tO\na\tO\nfulminant\tO\ncourse\tO\nof\tO\nposterior\tB-Disease\nleukoencephalopathy\tI-Disease\nor\tO\nposterior\tB-Disease\nreversible\tI-Disease\nencephalopathy\tI-Disease\nsyndrome\tI-Disease\ndeveloped\tO\n110\tO\ndays\tO\nafter\tO\ntransplant\tO\n.\tO\n\nAfter\tO\nan\tO\ninitially\tO\nuneventful\tO\ncourse\tO\nafter\tO\nthe\tO\ntransplant\tO\n,\tO\nthe\tO\npatient\tO\nrapidly\tO\nfell\tO\ninto\tO\ndeep\tO\ncoma\tO\n.\tO\n\nRESULTS\tO\n:\tO\nCerebral\tO\nMRI\tO\nscan\tO\nshowed\tO\ntypical\tO\nsigns\tO\nof\tO\nenhancement\tO\nin\tO\nthe\tO\npontine\tO\nand\tO\nposterior\tO\nregions\tO\n.\tO\n\nSwitching\tO\nthe\tO\nimmunosuppressive\tO\nregimen\tO\nfrom\tO\ntacrolimus\tB-Chemical\nto\tO\ncyclosporine\tB-Chemical\ndid\tO\nnot\tO\nimprove\tO\nthe\tO\nclinical\tO\nsituation\tO\n.\tO\n\nThe\tO\ntermination\tO\nof\tO\ntreatment\tO\nwith\tO\nany\tO\ncalcineurin\tO\ninhibitor\tO\nresulted\tO\nin\tO\na\tO\ncomplete\tO\nresolution\tO\nof\tO\nthat\tO\ncomplication\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPosterior\tB-Disease\nreversible\tI-Disease\nencephalopathy\tI-Disease\nsyndrome\tI-Disease\nafter\tO\nliver\tO\ntransplant\tO\nis\tO\nrare\tO\n.\tO\n\nWe\tO\nrecommend\tO\na\tO\ncomplete\tO\ncessation\tO\nof\tO\nany\tO\ncalcineurin\tO\ninhibitor\tO\nrather\tO\nthan\tO\na\tO\ndose\tO\nreduction\tO\n.\tO\n\nProlonged\tO\nhypothermia\tB-Disease\nas\tO\na\tO\nbridge\tO\nto\tO\nrecovery\tO\nfor\tO\ncerebral\tB-Disease\nedema\tI-Disease\nand\tO\nintracranial\tB-Disease\nhypertension\tI-Disease\nassociated\tO\nwith\tO\nfulminant\tB-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nTo\tO\nreview\tO\nevidence\tO\n-\tO\nbased\tO\ntreatment\tO\noptions\tO\nin\tO\npatients\tO\nwith\tO\ncerebral\tB-Disease\nedema\tI-Disease\ncomplicating\tO\nfulminant\tB-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\n(\tO\nFHF\tB-Disease\n)\tO\nand\tO\ndiscuss\tO\nthe\tO\npotential\tO\napplications\tO\nof\tO\nhypothermia\tB-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nCase\tO\n-\tO\nbased\tO\nobservations\tO\nfrom\tO\na\tO\nmedical\tO\nintensive\tO\ncare\tO\nunit\tO\n(\tO\nMICU\tO\n)\tO\nin\tO\na\tO\ntertiary\tO\ncare\tO\nfacility\tO\nin\tO\na\tO\n27\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfemale\tO\nwith\tO\nFHF\tB-Disease\nfrom\tO\nacetaminophen\tB-Chemical\nand\tO\nresultant\tO\ncerebral\tB-Disease\nedema\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nOur\tO\npatient\tO\nwas\tO\nadmitted\tO\nto\tO\nthe\tO\nMICU\tO\nafter\tO\nbeing\tO\nfound\tO\nunresponsive\tO\nwith\tO\npresumed\tO\ntoxicity\tB-Disease\nfrom\tO\nacetaminophen\tB-Chemical\nwhich\tO\nwas\tO\ningested\tO\nover\tO\na\tO\n2\tO\n-\tO\nday\tO\nperiod\tO\n.\tO\n\nThe\tO\npatient\tO\nhad\tO\ndepressed\tO\nof\tO\nmental\tO\nstatus\tO\nlasting\tO\nat\tO\nleast\tO\n24\tO\nh\tO\nprior\tO\nto\tO\nadmission\tO\n.\tO\n\nInitial\tO\nevaluation\tO\nconfirmed\tO\nFHF\tB-Disease\nfrom\tO\nacetaminophen\tB-Chemical\nand\tO\ncerebral\tB-Disease\nedema\tI-Disease\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\ntreated\tO\nwith\tO\nhyperosmolar\tO\ntherapy\tO\n,\tO\nhyperventilation\tB-Disease\n,\tO\nsedation\tO\n,\tO\nand\tO\nchemical\tO\nparalysis\tB-Disease\n.\tO\n\nHer\tO\nintracranial\tO\npressure\tO\nremained\tO\nelevated\tO\ndespite\tO\nmaximal\tO\nmedical\tO\ntherapy\tO\n.\tO\n\nWe\tO\nthen\tO\ninitiated\tO\ntherapeutic\tO\nhypothermia\tB-Disease\nwhich\tO\nwas\tO\ncontinued\tO\nfor\tO\n5\tO\ndays\tO\n.\tO\n\nAt\tO\nre\tO\n-\tO\nwarming\tO\n,\tO\npatient\tO\nhad\tO\nresolution\tO\nof\tO\nher\tO\ncerebral\tB-Disease\nedema\tI-Disease\nand\tO\nintracranial\tB-Disease\nhypertension\tI-Disease\n.\tO\n\nAt\tO\ndischarge\tO\n,\tO\nshe\tO\nhad\tO\ncomplete\tO\nrecovery\tO\nof\tO\nneurological\tO\nand\tO\nhepatic\tO\nfunctions\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\npatients\tO\nwith\tO\nFHF\tB-Disease\nand\tO\ncerebral\tB-Disease\nedema\tI-Disease\nfrom\tO\nacetaminophen\tB-Chemical\noverdose\tB-Disease\n,\tO\nprolonged\tO\ntherapeutic\tO\nhypothermia\tB-Disease\ncould\tO\npotentially\tO\nbe\tO\nused\tO\nas\tO\na\tO\nlife\tO\nsaving\tO\ntherapy\tO\nand\tO\na\tO\nbridge\tO\nto\tO\nhepatic\tO\nand\tO\nneurological\tO\nrecovery\tO\n.\tO\n\nA\tO\nclinical\tO\ntrial\tO\nof\tO\nhypothermia\tB-Disease\nin\tO\npatients\tO\nwith\tO\nthis\tO\ncondition\tO\nis\tO\nwarranted\tO\n.\tO\n\nBinasal\tB-Disease\nvisual\tI-Disease\nfield\tI-Disease\ndefects\tI-Disease\nare\tO\nnot\tO\nspecific\tO\nto\tO\nvigabatrin\tB-Chemical\n.\tO\n\nThis\tO\nstudy\tO\ninvestigated\tO\nthe\tO\nvisual\tB-Disease\ndefects\tI-Disease\nassociated\tO\nwith\tO\nthe\tO\nantiepileptic\tO\ndrug\tO\nvigabatrin\tB-Chemical\n(\tO\nVGB\tB-Chemical\n)\tO\n.\tO\n\nTwo\tO\nhundred\tO\nfour\tO\npeople\tO\nwith\tO\nepilepsy\tB-Disease\nwere\tO\ngrouped\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\nantiepileptic\tO\ndrug\tO\ntherapy\tO\n(\tO\ncurrent\tO\n,\tO\nprevious\tO\n,\tO\nor\tO\nno\tO\nexposure\tO\nto\tO\nVGB\tB-Chemical\n)\tO\n.\tO\n\nGroups\tO\nwere\tO\nmatched\tO\nwith\tO\nrespect\tO\nto\tO\nage\tO\n,\tO\ngender\tO\n,\tO\nand\tO\nseizure\tB-Disease\nfrequency\tO\n.\tO\n\nAll\tO\npatients\tO\nunderwent\tO\nobjective\tO\nassessment\tO\nof\tO\nelectrophysiological\tO\nfunction\tO\n(\tO\nwide\tO\n-\tO\nfield\tO\nmultifocal\tO\nelectroretinography\tO\n)\tO\nand\tO\nconventional\tO\nvisual\tO\nfield\tO\ntesting\tO\n(\tO\nstatic\tO\nperimetry\tO\n)\tO\n.\tO\n\nBilateral\tO\nvisual\tO\nfield\tO\nconstriction\tO\nwas\tO\nobserved\tO\nin\tO\n59\tO\n%\tO\nof\tO\npatients\tO\ncurrently\tO\ntaking\tO\nVGB\tB-Chemical\n,\tO\n43\tO\n%\tO\nof\tO\npatients\tO\nwho\tO\npreviously\tO\ntook\tO\nVGB\tB-Chemical\n,\tO\nand\tO\n24\tO\n%\tO\nof\tO\npatients\tO\nwith\tO\nno\tO\nexposure\tO\nto\tO\nVGB\tB-Chemical\n.\tO\n\nAssessment\tO\nof\tO\nretinal\tO\nfunction\tO\nrevealed\tO\nabnormal\tO\nresponses\tO\nin\tO\n48\tO\n%\tO\nof\tO\ncurrent\tO\nVGB\tB-Chemical\nusers\tO\nand\tO\n22\tO\n%\tO\nof\tO\nprior\tO\nVGB\tB-Chemical\nusers\tO\n,\tO\nbut\tO\nin\tO\nnone\tO\nof\tO\nthe\tO\npatients\tO\nwithout\tO\nprevious\tO\nexposure\tO\nto\tO\nVGB\tB-Chemical\n.\tO\n\nBilateral\tB-Disease\nvisual\tI-Disease\nfield\tI-Disease\nabnormalities\tI-Disease\nare\tO\ncommon\tO\nin\tO\nthe\tO\ntreated\tO\nepilepsy\tB-Disease\npopulation\tO\n,\tO\nirrespective\tO\nof\tO\ndrug\tO\nhistory\tO\n.\tO\n\nAssessment\tO\nby\tO\nconventional\tO\nstatic\tO\nperimetry\tO\nmay\tO\nneither\tO\nbe\tO\nsufficiently\tO\nsensitive\tO\nnor\tO\nspecific\tO\nto\tO\nreliably\tO\nidentify\tO\nretinal\tB-Disease\ntoxicity\tI-Disease\nassociated\tO\nwith\tO\nVGB\tB-Chemical\n.\tO\n\nSmoking\tO\nof\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nas\tO\na\tO\nrisk\tO\nfactor\tO\nfor\tO\nHIV\tB-Disease\ninfection\tI-Disease\namong\tO\npeople\tO\nwho\tO\nuse\tO\ninjection\tO\ndrugs\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nLittle\tO\nis\tO\nknown\tO\nabout\tO\nthe\tO\npossible\tO\nrole\tO\nthat\tO\nsmoking\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nhas\tO\non\tO\nthe\tO\nincidence\tO\nof\tO\nHIV\tB-Disease\ninfection\tI-Disease\n.\tO\n\nGiven\tO\nthe\tO\nincreasing\tO\nuse\tO\nof\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\n,\tO\nwe\tO\nsought\tO\nto\tO\nexamine\tO\nwhether\tO\nuse\tO\nof\tO\nthis\tO\nillicit\tO\ndrug\tO\nhas\tO\nbecome\tO\na\tO\nrisk\tO\nfactor\tO\nfor\tO\nHIV\tB-Disease\ninfection\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nincluded\tO\ndata\tO\nfrom\tO\npeople\tO\nparticipating\tO\nin\tO\nthe\tO\nVancouver\tO\nInjection\tO\nDrug\tO\nUsers\tO\nStudy\tO\nwho\tO\nreported\tO\ninjecting\tO\nillicit\tO\ndrugs\tO\nat\tO\nleast\tO\nonce\tO\nin\tO\nthe\tO\nmonth\tO\nbefore\tO\nenrolment\tO\n,\tO\nlived\tO\nin\tO\nthe\tO\ngreater\tO\nVancouver\tO\narea\tO\n,\tO\nwere\tO\nHIV\tO\n-\tO\nnegative\tO\nat\tO\nenrolment\tO\nand\tO\ncompleted\tO\nat\tO\nleast\tO\n1\tO\nfollow\tO\n-\tO\nup\tO\nstudy\tO\nvisit\tO\n.\tO\n\nTo\tO\ndetermine\tO\nwhether\tO\nthe\tO\nrisk\tO\nof\tO\nHIV\tB-Disease\nseroconversion\tI-Disease\namong\tO\ndaily\tO\nsmokers\tO\nof\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nchanged\tO\nover\tO\ntime\tO\n,\tO\nwe\tO\nused\tO\nCox\tO\nproportional\tO\nhazards\tO\nregression\tO\nand\tO\ndivided\tO\nthe\tO\nstudy\tO\ninto\tO\n3\tO\nperiods\tO\n:\tO\nMay\tO\n1\tO\n,\tO\n1996\tO\n-\tO\nNov\tO\n.\tO\n\n30\tO\n,\tO\n1999\tO\n(\tO\nperiod\tO\n1\tO\n)\tO\n,\tO\nDec\tO\n.\tO\n\n1\tO\n,\tO\n1999\tO\n-\tO\nNov\tO\n.\tO\n\n30\tO\n,\tO\n2002\tO\n(\tO\nperiod\tO\n2\tO\n)\tO\n,\tO\nand\tO\nDec\tO\n.\tO\n\n1\tO\n,\tO\n2002\tO\n-\tO\nDec\tO\n.\tO\n\n30\tO\n,\tO\n2005\tO\n(\tO\nperiod\tO\n3\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOverall\tO\n,\tO\n1048\tO\neligible\tO\ninjection\tO\ndrug\tO\nusers\tO\nwere\tO\nincluded\tO\nin\tO\nour\tO\nstudy\tO\n.\tO\n\nOf\tO\nthese\tO\n,\tO\n137\tO\nacquired\tO\nHIV\tB-Disease\ninfection\tI-Disease\nduring\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nThe\tO\nmean\tO\nproportion\tO\nof\tO\nparticipants\tO\nwho\tO\nreported\tO\ndaily\tO\nsmoking\tO\nof\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nincreased\tO\nfrom\tO\n11\tO\n.\tO\n6\tO\n%\tO\nin\tO\nperiod\tO\n1\tO\nto\tO\n39\tO\n.\tO\n7\tO\n%\tO\nin\tO\nperiod\tO\n3\tO\n.\tO\n\nAfter\tO\nadjusting\tO\nfor\tO\npotential\tO\nconfounders\tO\n,\tO\nwe\tO\nfound\tO\nthat\tO\nthe\tO\nrisk\tO\nof\tO\nHIV\tB-Disease\nseroconversion\tI-Disease\namong\tO\nparticipants\tO\nwho\tO\nwere\tO\ndaily\tO\nsmokers\tO\nof\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nincreased\tO\nover\tO\ntime\tO\n(\tO\nperiod\tO\n1\tO\n:\tO\nhazard\tO\nratio\tO\n[\tO\nHR\tO\n]\tO\n1\tO\n.\tO\n03\tO\n,\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n0\tO\n.\tO\n57\tO\n-\tO\n1\tO\n.\tO\n85\tO\n;\tO\nperiod\tO\n2\tO\n:\tO\nHR\tO\n1\tO\n.\tO\n68\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n01\tO\n-\tO\n2\tO\n.\tO\n80\tO\n;\tO\nand\tO\nperiod\tO\n3\tO\n:\tO\nHR\tO\n2\tO\n.\tO\n74\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n06\tO\n-\tO\n7\tO\n.\tO\n11\tO\n)\tO\n.\tO\n\nINTERPRETATION\tO\n:\tO\nSmoking\tO\nof\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\nwas\tO\nfound\tO\nto\tO\nbe\tO\nan\tO\nindependent\tO\nrisk\tO\nfactor\tO\nfor\tO\nHIV\tB-Disease\nseroconversion\tI-Disease\namong\tO\npeople\tO\nwho\tO\nwere\tO\ninjection\tO\ndrug\tO\nusers\tO\n.\tO\n\nThis\tO\nfinding\tO\npoints\tO\nto\tO\nthe\tO\nurgent\tO\nneed\tO\nfor\tO\nevidence\tO\n-\tO\nbased\tO\npublic\tO\nhealth\tO\ninitiatives\tO\ntargeted\tO\nat\tO\npeople\tO\nwho\tO\nsmoke\tO\ncrack\tB-Chemical\ncocaine\tI-Chemical\n.\tO\n\nFluoxetine\tB-Chemical\nimproves\tO\nthe\tO\nmemory\tB-Disease\ndeficits\tI-Disease\ncaused\tO\nby\tO\nthe\tO\nchemotherapy\tO\nagent\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n.\tO\n\nCancer\tB-Disease\npatients\tO\nwho\tO\nhave\tO\nbeen\tO\ntreated\tO\nwith\tO\nsystemic\tO\nadjuvant\tO\nchemotherapy\tO\nhave\tO\ndescribed\tO\nexperiencing\tO\ndeteriorations\tO\nin\tO\ncognition\tO\n.\tO\n\nA\tO\nwidely\tO\nused\tO\nchemotherapeutic\tO\nagent\tO\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\n,\tO\nreadily\tO\ncrosses\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\nand\tO\nso\tO\ncould\tO\nhave\tO\na\tO\ndirect\tO\neffect\tO\non\tO\nbrain\tO\nfunction\tO\n.\tO\n\nIn\tO\nparticular\tO\nthis\tO\nanti\tO\nmitotic\tO\ndrug\tO\ncould\tO\nreduce\tO\ncell\tO\nproliferation\tO\nin\tO\nthe\tO\nneurogenic\tO\nregions\tO\nof\tO\nthe\tO\nadult\tO\nbrain\tO\n.\tO\n\nIn\tO\ncontrast\tO\nreports\tO\nindicate\tO\nthat\tO\nhippocampal\tO\ndependent\tO\nneurogenesis\tO\nand\tO\ncognition\tO\nare\tO\nenhanced\tO\nby\tO\nthe\tO\nSSRI\tB-Chemical\nantidepressant\tO\nFluoxetine\tB-Chemical\n.\tO\n\nIn\tO\nthis\tO\ninvestigation\tO\nthe\tO\nbehavioural\tO\neffects\tO\nof\tO\nchronic\tO\n(\tO\ntwo\tO\nweek\tO\n)\tO\ntreatment\tO\nwith\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nand\tO\n(\tO\nthree\tO\nweeks\tO\n)\tO\nwith\tO\nFluoxetine\tB-Chemical\neither\tO\nseparately\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nwere\tO\ntested\tO\non\tO\nadult\tO\nLister\tO\nhooded\tO\nrats\tO\n.\tO\n\nBehavioural\tO\neffects\tO\nwere\tO\ntested\tO\nusing\tO\na\tO\ncontext\tO\ndependent\tO\nconditioned\tO\nemotional\tO\nresponse\tO\ntest\tO\n(\tO\nCER\tO\n)\tO\nwhich\tO\nshowed\tO\nthat\tO\nanimals\tO\ntreated\tO\nwith\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nhad\tO\na\tO\nsignificant\tO\nreduction\tO\nin\tO\nfreezing\tO\ntime\tO\ncompared\tO\nto\tO\ncontrols\tO\n.\tO\n\nA\tO\nseparate\tO\ngroup\tO\nof\tO\nanimals\tO\nwas\tO\ntested\tO\nusing\tO\na\tO\nhippocampal\tO\ndependent\tO\nspatial\tO\nworking\tO\nmemory\tO\ntest\tO\n,\tO\nthe\tO\nobject\tO\nlocation\tO\nrecognition\tO\ntest\tO\n(\tO\nOLR\tO\n)\tO\n.\tO\n\nAnimals\tO\ntreated\tO\nonly\tO\nwith\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nshowed\tO\nsignificant\tO\ndeficits\tO\nin\tO\ntheir\tO\nability\tO\nto\tO\ncarry\tO\nout\tO\nthe\tO\nOLR\tO\ntask\tO\nbut\tO\nco\tO\nadministration\tO\nof\tO\nFluoxetine\tB-Chemical\nimproved\tO\ntheir\tO\nperformance\tO\n.\tO\n\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nchemotherapy\tO\ncaused\tO\na\tO\nsignificant\tO\nreduction\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nproliferating\tO\ncells\tO\nin\tO\nthe\tO\nsub\tO\ngranular\tO\nzone\tO\nof\tO\nthe\tO\ndentate\tO\ngyrus\tO\ncompared\tO\nto\tO\ncontrols\tO\n.\tO\n\nThis\tO\nreduction\tO\nwas\tO\neliminated\tO\nwhen\tO\nFluoxetine\tB-Chemical\nwas\tO\nco\tO\nadministered\tO\nwith\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n.\tO\n\nFluoxetine\tB-Chemical\non\tO\nits\tO\nown\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nproliferating\tO\ncell\tO\nnumber\tO\nor\tO\nbehaviour\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ncan\tO\nnegatively\tO\naffect\tO\nboth\tO\ncell\tO\nproliferation\tO\nand\tO\nhippocampal\tO\ndependent\tO\nworking\tO\nmemory\tO\nand\tO\nthat\tO\nthese\tO\ndeficits\tO\ncan\tO\nbe\tO\nreversed\tO\nby\tO\nthe\tO\nsimultaneous\tO\nadministration\tO\nof\tO\nthe\tO\nantidepressant\tO\nFluoxetine\tB-Chemical\n.\tO\n\nLiver\tO\n-\tO\nspecific\tO\nablation\tO\nof\tO\nintegrin\tO\n-\tO\nlinked\tO\nkinase\tO\nin\tO\nmice\tO\nresults\tO\nin\tO\nenhanced\tO\nand\tO\nprolonged\tO\ncell\tO\nproliferation\tO\nand\tO\nhepatomegaly\tB-Disease\nafter\tO\nphenobarbital\tB-Chemical\nadministration\tO\n.\tO\n\nWe\tO\nhave\tO\nrecently\tO\ndemonstrated\tO\nthat\tO\ndisruption\tO\nof\tO\nextracellular\tO\nmatrix\tO\n(\tO\nECM\tO\n)\tO\n/\tO\nintegrin\tO\nsignaling\tO\nvia\tO\nelimination\tO\nof\tO\nintegrin\tO\n-\tO\nlinked\tO\nkinase\tO\n(\tO\nILK\tO\n)\tO\nin\tO\nhepatocytes\tO\ninterferes\tO\nwith\tO\nsignals\tO\nleading\tO\nto\tO\ntermination\tO\nof\tO\nliver\tO\nregeneration\tO\n.\tO\n\nThis\tO\nstudy\tO\ninvestigates\tO\nthe\tO\nrole\tO\nof\tO\nILK\tO\nin\tO\nliver\tO\nenlargement\tO\ninduced\tO\nby\tO\nphenobarbital\tB-Chemical\n(\tO\nPB\tB-Chemical\n)\tO\n.\tO\n\nWild\tO\n-\tO\ntype\tO\n(\tO\nWT\tO\n)\tO\nand\tO\nILK\tO\n:\tO\nliver\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nwere\tO\ngiven\tO\nPB\tB-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n%\tO\nin\tO\ndrinking\tO\nwater\tO\n)\tO\nfor\tO\n10\tO\ndays\tO\n.\tO\n\nLivers\tO\nwere\tO\nharvested\tO\non\tO\n2\tO\n,\tO\n5\tO\n,\tO\nand\tO\n10\tO\ndays\tO\nduring\tO\nPB\tB-Chemical\nadministration\tO\n.\tO\n\nIn\tO\nthe\tO\nhepatocyte\tO\n-\tO\nspecific\tO\nILK\tO\n/\tO\nliver\tO\n-\tO\n/\tO\n-\tO\nmice\tO\n,\tO\nthe\tO\nliver\tO\n:\tO\nbody\tO\nweight\tO\nratio\tO\nwas\tO\nmore\tO\nthan\tO\ndouble\tO\nas\tO\ncompared\tO\nto\tO\n0\tO\nh\tO\nat\tO\nday\tO\n2\tO\n(\tO\n2\tO\n.\tO\n5\tO\ntimes\tO\n)\tO\n,\tO\nwhile\tO\nat\tO\ndays\tO\n5\tO\nand\tO\n10\tO\n,\tO\nit\tO\nwas\tO\nenlarged\tO\nthree\tO\ntimes\tO\n.\tO\n\nIn\tO\nthe\tO\nWT\tO\nmice\tO\n,\tO\nthe\tO\nincrease\tO\nwas\tO\nas\tO\nexpected\tO\nfrom\tO\nprevious\tO\nliterature\tO\n(\tO\n1\tO\n.\tO\n8\tO\ntimes\tO\n)\tO\nand\tO\nseems\tO\nto\tO\nhave\tO\nleveled\tO\noff\tO\nafter\tO\nday\tO\n2\tO\n.\tO\n\nThere\tO\nwere\tO\nslightly\tO\nincreased\tO\nproliferating\tO\ncell\tO\nnuclear\tO\nantigen\tO\n-\tO\npositive\tO\ncells\tO\nin\tO\nthe\tO\nILK\tO\n/\tO\nliver\tO\n-\tO\n/\tO\n-\tO\nanimals\tO\nat\tO\nday\tO\n2\tO\nas\tO\ncompared\tO\nto\tO\nWT\tO\nafter\tO\nPB\tB-Chemical\nadministration\tO\n.\tO\n\nIn\tO\nthe\tO\nWT\tO\nanimals\tO\n,\tO\nthe\tO\nproliferative\tO\nresponse\tO\nhad\tO\ncome\tO\nback\tO\nto\tO\nnormal\tO\nby\tO\ndays\tO\n5\tO\nand\tO\n10\tO\n.\tO\n\nHepatocytes\tO\nof\tO\nthe\tO\nILK\tO\n/\tO\nliver\tO\n-\tO\n/\tO\n-\tO\nmice\tO\ncontinued\tO\nto\tO\nproliferate\tO\nup\tO\nuntil\tO\nday\tO\n10\tO\n.\tO\n\nILK\tO\n/\tO\nliver\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nalso\tO\nshowed\tO\nincreased\tO\nexpression\tO\nof\tO\nkey\tO\ngenes\tO\ninvolved\tO\nin\tO\nhepatocyte\tO\nproliferation\tO\nat\tO\ndifferent\tO\ntime\tO\npoints\tO\nduring\tO\nPB\tB-Chemical\nadministration\tO\n.\tO\n\nIn\tO\nsummary\tO\n,\tO\nECM\tO\nproteins\tO\ncommunicate\tO\nwith\tO\nthe\tO\nsignaling\tO\nmachinery\tO\nof\tO\ndividing\tO\ncells\tO\nvia\tO\nILK\tO\nto\tO\nregulate\tO\nhepatocyte\tO\nproliferation\tO\nand\tO\ntermination\tO\nof\tO\nthe\tO\nproliferative\tO\nresponse\tO\n.\tO\n\nLack\tO\nof\tO\nILK\tO\nin\tO\nthe\tO\nhepatocytes\tO\nimparts\tO\nprolonged\tO\nproliferative\tO\nresponse\tO\nnot\tO\nonly\tO\nto\tO\nstimuli\tO\nrelated\tO\nto\tO\nliver\tO\nregeneration\tO\nbut\tO\nalso\tO\nto\tO\nxenobiotic\tO\nchemical\tO\nmitogens\tO\n,\tO\nsuch\tO\nas\tO\nPB\tB-Chemical\n.\tO\n\nDecreased\tO\nExpression\tO\nof\tO\nNa\tB-Chemical\n/\tO\nK\tB-Chemical\n-\tO\nATPase\tO\n,\tO\nNHE3\tO\n,\tO\nNBC1\tO\n,\tO\nAQP1\tO\nand\tO\nOAT\tO\nin\tO\nGentamicin\tB-Chemical\n-\tO\ninduced\tO\nNephropathy\tB-Disease\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\naimed\tO\nto\tO\ndetermine\tO\nwhether\tO\nthere\tO\nis\tO\nan\tO\naltered\tO\nregulation\tO\nof\tO\ntubular\tO\ntransporters\tO\nin\tO\ngentamicin\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n.\tO\n\nSprague\tO\n-\tO\nDawley\tO\nmale\tO\nrats\tO\n(\tO\n200\tO\n~\tO\n250\tO\ng\tO\n)\tO\nwere\tO\nsubcutaneously\tO\ninjected\tO\nwith\tO\ngentamicin\tB-Chemical\n(\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\n)\tO\nfor\tO\n7\tO\ndays\tO\n,\tO\nand\tO\nthe\tO\nexpression\tO\nof\tO\ntubular\tO\ntransporters\tO\nwas\tO\ndetermined\tO\nby\tO\nimmunoblotting\tO\nand\tO\nimmunohistochemistry\tO\n.\tO\n\nThe\tO\nmRNA\tO\nand\tO\nprotein\tO\nexpression\tO\nof\tO\nOAT\tO\nwas\tO\nalso\tO\ndetermined\tO\n.\tO\n\nGentamicin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nexhibited\tO\nsignificantly\tO\ndecreased\tO\ncreatinine\tB-Chemical\nclearance\tO\nalong\tO\nwith\tO\nincreased\tO\nplasma\tO\ncreatinine\tB-Chemical\nlevels\tO\n.\tO\n\nAccordingly\tO\n,\tO\nthe\tO\nfractional\tO\nexcretion\tO\nof\tO\nsodium\tB-Chemical\nincreased\tO\n.\tO\n\nUrine\tO\nvolume\tO\nwas\tO\nincreased\tO\n,\tO\nwhile\tO\nurine\tO\nosmolality\tO\nand\tO\nfree\tO\nwater\tO\nreabsorption\tO\nwere\tO\ndecreased\tO\n.\tO\n\nImmunoblotting\tO\nand\tO\nimmunohistochemistry\tO\nrevealed\tO\ndecreased\tO\nexpression\tO\nof\tO\nNa\tB-Chemical\n(\tO\n+\tO\n)\tO\n/\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nATPase\tO\n,\tO\nNHE3\tO\n,\tO\nNBC1\tO\n,\tO\nand\tO\nAQP1\tO\nin\tO\nthe\tO\nkidney\tO\nof\tO\ngentamicin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nThe\tO\nexpression\tO\nof\tO\nOAT1\tO\nand\tO\nOAT3\tO\nwas\tO\nalso\tO\ndecreased\tO\n.\tO\n\nGentamicin\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\nmay\tO\nat\tO\nleast\tO\nin\tO\npart\tO\nbe\tO\ncausally\tO\nrelated\tO\nwith\tO\na\tO\ndecreased\tO\nexpression\tO\nof\tO\nNa\tB-Chemical\n(\tO\n+\tO\n)\tO\n/\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n-\tO\nATPase\tO\n,\tO\nNHE3\tO\n,\tO\nNBC1\tO\n,\tO\nAQP1\tO\nand\tO\nOAT\tO\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nafter\tO\nhigh\tO\n-\tO\ndose\tO\nmethotrexate\tB-Chemical\ntherapy\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nileostomy\tO\n.\tO\n\nHigh\tO\n-\tO\ndose\tO\nmethotrexate\tB-Chemical\n(\tO\nHD\tO\n-\tO\nMTX\tB-Chemical\n)\tO\nis\tO\nan\tO\nimportant\tO\ntreatment\tO\nfor\tO\nBurkitt\tB-Disease\nlymphoma\tI-Disease\n,\tO\nbut\tO\ncan\tO\ncause\tO\nhepatic\tB-Disease\nand\tI-Disease\nrenal\tI-Disease\ntoxicity\tI-Disease\nwhen\tO\nits\tO\nclearance\tO\nis\tO\ndelayed\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nafter\tO\nHD\tO\n-\tO\nMTX\tB-Chemical\ntherapy\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nileostomy\tO\n,\tO\nThe\tO\npatient\tO\nwas\tO\na\tO\n3\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwho\tO\nhad\tO\nreceived\tO\na\tO\nliving\tO\n-\tO\nrelated\tO\nliver\tO\ntransplantation\tO\nfor\tO\ncongenital\tO\nbiliary\tB-Disease\natresia\tI-Disease\n.\tO\n\nAt\tO\nday\tO\n833\tO\nafter\tO\nthe\tO\ntransplantation\tO\n,\tO\nhe\tO\nwas\tO\ndiagnosed\tO\nwith\tO\nPTLD\tB-Disease\n(\tO\npost\tB-Disease\n-\tI-Disease\ntransplantation\tI-Disease\nlymphoproliferative\tI-Disease\ndisorder\tI-Disease\n,\tO\nBurkitt\tB-Disease\n-\tI-Disease\ntype\tI-Disease\nmalignant\tI-Disease\nlymphoma\tI-Disease\n)\tO\n.\tO\n\nDuring\tO\ninduction\tO\ntherapy\tO\n,\tO\nhe\tO\nsuffered\tO\nileal\tO\nperforation\tO\nand\tO\nileostomy\tO\nwas\tO\nperformed\tO\n.\tO\n\nSubsequent\tO\nHD\tO\n-\tO\nMTX\tB-Chemical\ntherapy\tO\ncaused\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nthat\tO\nrequired\tO\ncontinuous\tO\nhemodialysis\tO\n.\tO\n\nWe\tO\nsupposed\tO\nthat\tO\nintravascular\tO\nhypovolemia\tB-Disease\ndue\tO\nto\tO\nsubstantial\tO\ndrainage\tO\nfrom\tO\nthe\tO\nileostoma\tO\ncaused\tO\nacute\tB-Disease\nprerenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nAfter\tO\nrecovery\tO\nof\tO\nhis\tO\nrenal\tO\nfunction\tO\n,\tO\nwe\tO\ncould\tO\nsafely\tO\ntreat\tO\nthe\tO\npatient\tO\nwith\tO\nHD\tO\n-\tO\nMTX\tB-Chemical\ntherapy\tO\nby\tO\ncontrolling\tO\ndrainage\tO\nfrom\tO\nileostoma\tO\nwith\tO\ntotal\tO\nparenteral\tO\nnutrition\tO\n.\tO\n\nLongitudinal\tO\nassociation\tO\nof\tO\nalcohol\tB-Chemical\nuse\tO\nwith\tO\nHIV\tB-Disease\ndisease\tI-Disease\nprogression\tO\nand\tO\npsychological\tO\nhealth\tO\nof\tO\nwomen\tO\nwith\tO\nHIV\tO\n.\tO\n\nWe\tO\nevaluated\tO\nthe\tO\nassociation\tO\nof\tO\nalcohol\tB-Chemical\nconsumption\tO\nand\tO\ndepression\tB-Disease\n,\tO\nand\tO\ntheir\tO\neffects\tO\non\tO\nHIV\tB-Disease\ndisease\tI-Disease\nprogression\tO\namong\tO\nwomen\tO\nwith\tO\nHIV\tO\n.\tO\n\nThe\tO\nstudy\tO\nincluded\tO\n871\tO\nwomen\tO\nwith\tO\nHIV\tO\nwho\tO\nwere\tO\nrecruited\tO\nfrom\tO\n1993\tO\n-\tO\n1995\tO\nin\tO\nfour\tO\nUS\tO\ncities\tO\n.\tO\n\nThe\tO\nparticipants\tO\nhad\tO\nphysical\tO\nexamination\tO\n,\tO\nmedical\tO\nrecord\tO\nextraction\tO\n,\tO\nand\tO\nvenipuncture\tO\n,\tO\nCD4\tO\n+\tO\nT\tO\n-\tO\ncell\tO\ncounts\tO\ndetermination\tO\n,\tO\nmeasurement\tO\nof\tO\ndepression\tB-Disease\nsymptoms\tO\n(\tO\nusing\tO\nthe\tO\nself\tO\n-\tO\nreport\tO\nCenter\tO\nfor\tO\nEpidemiological\tO\nStudies\tO\n-\tO\nDepression\tB-Disease\nScale\tO\n)\tO\n,\tO\nand\tO\nalcohol\tB-Chemical\nuse\tO\nassessment\tO\nat\tO\nenrollment\tO\n,\tO\nand\tO\nsemiannually\tO\nuntil\tO\nMarch\tO\n2000\tO\n.\tO\n\nMultilevel\tO\nrandom\tO\ncoefficient\tO\nordinal\tO\nmodels\tO\nas\tO\nwell\tO\nas\tO\nmultilevel\tO\nmodels\tO\nwith\tO\njoint\tO\nresponses\tO\nwere\tO\nused\tO\nin\tO\nthe\tO\nanalysis\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nsignificant\tO\nassociation\tO\nbetween\tO\nlevel\tO\nof\tO\nalcohol\tB-Chemical\nuse\tO\nand\tO\nCD4\tO\n+\tO\nT\tO\n-\tO\ncell\tO\ncounts\tO\n.\tO\n\nWhen\tO\nparticipants\tO\nwere\tO\nstratified\tO\nby\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nART\tO\n)\tO\nuse\tO\n,\tO\nthe\tO\nassociation\tO\nbetween\tO\nalcohol\tB-Chemical\nand\tO\nCD4\tO\n+\tO\nT\tO\n-\tO\ncell\tO\ndid\tO\nnot\tO\nreach\tO\nstatistical\tO\nsignificance\tO\n.\tO\n\nThe\tO\nassociation\tO\nbetween\tO\nalcohol\tB-Chemical\nconsumption\tO\nand\tO\ndepression\tB-Disease\nwas\tO\nsignificant\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nDepression\tB-Disease\nhad\tO\na\tO\nsignificant\tO\nnegative\tO\neffect\tO\non\tO\nCD4\tO\n+\tO\nT\tO\n-\tO\ncell\tO\ncounts\tO\nover\tO\ntime\tO\nregardless\tO\nof\tO\nART\tO\nuse\tO\n.\tO\n\nOur\tO\nfindings\tO\nsuggest\tO\nthat\tO\nalcohol\tB-Chemical\nconsumption\tO\nhas\tO\na\tO\ndirect\tO\nassociation\tO\nwith\tO\ndepression\tB-Disease\n.\tO\n\nMoreover\tO\n,\tO\ndepression\tB-Disease\nis\tO\nassociated\tO\nwith\tO\nHIV\tB-Disease\ndisease\tI-Disease\nprogression\tO\n.\tO\n\nOur\tO\nfindings\tO\nhave\tO\nimplications\tO\nfor\tO\nthe\tO\nprovision\tO\nof\tO\nalcohol\tB-Chemical\nuse\tO\ninterventions\tO\nand\tO\npsychological\tO\nresources\tO\nto\tO\nimprove\tO\nthe\tO\nhealth\tO\nof\tO\nwomen\tO\nwith\tO\nHIV\tO\n.\tO\n\nChemokine\tO\nCCL2\tO\nand\tO\nits\tO\nreceptor\tO\nCCR2\tO\nare\tO\nincreased\tO\nin\tO\nthe\tO\nhippocampus\tO\nfollowing\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nNeuroinflammation\tB-Disease\noccurs\tO\nafter\tO\nseizures\tB-Disease\nand\tO\nis\tO\nimplicated\tO\nin\tO\nepileptogenesis\tO\n.\tO\n\nCCR2\tO\nis\tO\na\tO\nchemokine\tO\nreceptor\tO\nfor\tO\nCCL2\tO\nand\tO\ntheir\tO\ninteraction\tO\nmediates\tO\nmonocyte\tO\ninfiltration\tO\nin\tO\nthe\tO\nneuroinflammatory\tB-Disease\ncascade\tO\ntriggered\tO\nin\tO\ndifferent\tO\nbrain\tO\npathologies\tO\n.\tO\n\nIn\tO\nthis\tO\nwork\tO\nCCR2\tO\nand\tO\nCCL2\tO\nexpression\tO\nwere\tO\nexamined\tO\nfollowing\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n(\tO\nSE\tB-Disease\n)\tO\ninduced\tO\nby\tO\npilocarpine\tB-Chemical\ninjection\tO\n.\tO\n\nMETHODS\tO\n:\tO\nSE\tB-Disease\nwas\tO\ninduced\tO\nby\tO\npilocarpine\tB-Chemical\ninjection\tO\n.\tO\n\nControl\tO\nrats\tO\nwere\tO\ninjected\tO\nwith\tO\nsaline\tO\ninstead\tO\nof\tO\npilocarpine\tB-Chemical\n.\tO\n\nFive\tO\ndays\tO\nafter\tO\nSE\tB-Disease\n,\tO\nCCR2\tO\nstaining\tO\nin\tO\nneurons\tO\nand\tO\nglial\tO\ncells\tO\nwas\tO\nexamined\tO\nusing\tO\nimunohistochemical\tO\nanalyses\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\nCCR2\tO\npositive\tO\ncells\tO\nwas\tO\ndetermined\tO\nusing\tO\nstereology\tO\nprobes\tO\nin\tO\nthe\tO\nhippocampus\tO\n.\tO\n\nCCL2\tO\nexpression\tO\nin\tO\nthe\tO\nhippocampus\tO\nwas\tO\nexamined\tO\nby\tO\nmolecular\tO\nassay\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIncreased\tO\nCCR2\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\nhippocampus\tO\nafter\tO\nSE\tB-Disease\n.\tO\n\nSeizures\tB-Disease\nalso\tO\nresulted\tO\nin\tO\nalterations\tO\nto\tO\nthe\tO\ncell\tO\ntypes\tO\nexpressing\tO\nCCR2\tO\n.\tO\n\nIncreased\tO\nnumbers\tO\nof\tO\nneurons\tO\nthat\tO\nexpressed\tO\nCCR2\tO\nwas\tO\nobserved\tO\nfollowing\tO\nSE\tB-Disease\n.\tO\n\nMicroglial\tO\ncells\tO\nwere\tO\nmore\tO\nclosely\tO\napposed\tO\nto\tO\nthe\tO\nCCR2\tO\n-\tO\nlabeled\tO\ncells\tO\nin\tO\nSE\tB-Disease\nrats\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nrats\tO\nthat\tO\nexperienced\tO\nSE\tB-Disease\nexhibited\tO\nCCR2\tO\n-\tO\nlabeling\tO\nin\tO\npopulations\tO\nof\tO\nhypertrophied\tB-Disease\nastrocytes\tO\n,\tO\nespecially\tO\nin\tO\nCA1\tO\nand\tO\ndentate\tO\ngyrus\tO\n.\tO\n\nThese\tO\nCCR2\tO\n+\tO\nastroctytes\tO\nwere\tO\nnot\tO\nobserved\tO\nin\tO\ncontrol\tO\nrats\tO\n.\tO\n\nExamination\tO\nof\tO\nCCL2\tO\nexpression\tO\nshowed\tO\nthat\tO\nit\tO\nwas\tO\nelevated\tO\nin\tO\nthe\tO\nhippocampus\tO\nfollowing\tO\nSE\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\ndata\tO\nshow\tO\nthat\tO\nCCR2\tO\nand\tO\nCCL2\tO\nare\tO\nup\tO\n-\tO\nregulated\tO\nin\tO\nthe\tO\nhippocampus\tO\nafter\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nSE\tB-Disease\n.\tO\n\nSeizures\tB-Disease\nalso\tO\nresult\tO\nin\tO\nchanges\tO\nto\tO\nCCR2\tO\nreceptor\tO\nexpression\tO\nin\tO\nneurons\tO\nand\tO\nastrocytes\tO\n.\tO\n\nThese\tO\nchanges\tO\nmight\tO\nbe\tO\ninvolved\tO\nin\tO\ndetrimental\tO\nneuroplasticity\tO\nand\tO\nneuroinflammatory\tB-Disease\nchanges\tO\nthat\tO\noccur\tO\nfollowing\tO\nseizures\tB-Disease\n.\tO\n\nMetallothionein\tB-Chemical\ninduction\tO\nreduces\tO\ncaspase\tO\n-\tO\n3\tO\nactivity\tO\nand\tO\nTNFalpha\tO\nlevels\tO\nwith\tO\npreservation\tO\nof\tO\ncognitive\tO\nfunction\tO\nand\tO\nintact\tO\nhippocampal\tO\nneurons\tO\nin\tO\ncarmustine\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nHippocampal\tO\nintegrity\tO\nis\tO\nessential\tO\nfor\tO\ncognitive\tO\nfunctions\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\ninduction\tO\nof\tO\nmetallothionein\tB-Chemical\n(\tO\nMT\tB-Chemical\n)\tO\nby\tO\nZnSO\tB-Chemical\n(\tI-Chemical\n4\tI-Chemical\n)\tI-Chemical\nand\tO\nits\tO\nrole\tO\nin\tO\nneuroprotection\tO\nhas\tO\nbeen\tO\ndocumented\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\naimed\tO\nto\tO\nexplore\tO\nthe\tO\neffect\tO\nof\tO\nMT\tB-Chemical\ninduction\tO\non\tO\ncarmustine\tB-Chemical\n(\tO\nBCNU\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nhippocampal\tO\ncognitive\tB-Disease\ndysfunction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n60\tO\nmale\tO\nWistar\tO\nalbino\tO\nrats\tO\nwere\tO\nrandomly\tO\ndivided\tO\ninto\tO\nfour\tO\ngroups\tO\n(\tO\n15\tO\n/\tO\ngroup\tO\n)\tO\n:\tO\nThe\tO\ncontrol\tO\ngroup\tO\ninjected\tO\nwith\tO\nsingle\tO\ndoses\tO\nof\tO\nnormal\tO\nsaline\tO\n(\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n)\tO\nfollowed\tO\n24\tO\nh\tO\nlater\tO\nby\tO\nBCNU\tB-Chemical\nsolvent\tO\n(\tO\ni\tO\n.\tO\nv\tO\n)\tO\n.\tO\n\nThe\tO\nsecond\tO\ngroup\tO\nadministered\tO\nZnSO\tB-Chemical\n(\tI-Chemical\n4\tI-Chemical\n)\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmicromol\tO\n/\tO\n10\tO\nmicrol\tO\nnormal\tO\nsaline\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n,\tO\nonce\tO\n)\tO\nthen\tO\nBCNU\tB-Chemical\nsolvent\tO\n(\tO\ni\tO\n.\tO\nv\tO\n)\tO\nafter\tO\n24\tO\nh\tO\n.\tO\n\nThird\tO\ngroup\tO\nreceived\tO\nBCNU\tB-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\nv\tO\n,\tO\nonce\tO\n)\tO\n24\tO\nh\tO\nafter\tO\ninjection\tO\nwith\tO\nnormal\tO\nsaline\tO\n(\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n)\tO\n.\tO\n\nFourth\tO\ngroup\tO\nreceived\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nZnSO\tB-Chemical\n(\tI-Chemical\n4\tI-Chemical\n)\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmicromol\tO\n/\tO\n10\tO\nmicrol\tO\nnormal\tO\nsaline\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n)\tO\nthen\tO\nBCNU\tB-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\nv\tO\n,\tO\nonce\tO\n)\tO\nafter\tO\n24\tO\nh\tO\n.\tO\n\nThe\tO\nobtained\tO\ndata\tO\nrevealed\tO\nthat\tO\nBCNU\tB-Chemical\nadministration\tO\nresulted\tO\nin\tO\ndeterioration\tB-Disease\nof\tI-Disease\nlearning\tI-Disease\nand\tI-Disease\nshort\tI-Disease\n-\tI-Disease\nterm\tI-Disease\nmemory\tI-Disease\n(\tO\nSTM\tO\n)\tO\n,\tO\nas\tO\nmeasured\tO\nby\tO\nusing\tO\nradial\tO\narm\tO\nwater\tO\nmaze\tO\n,\tO\naccompanied\tO\nwith\tO\ndecreased\tO\nhippocampal\tO\nglutathione\tB-Chemical\nreductase\tO\n(\tO\nGR\tO\n)\tO\nactivity\tO\nand\tO\nreduced\tO\nglutathione\tB-Chemical\n(\tO\nGSH\tB-Chemical\n)\tO\ncontent\tO\n.\tO\n\nAlso\tO\n,\tO\nBCNU\tB-Chemical\nadministration\tO\nincreased\tO\nserum\tO\ntumor\tB-Disease\nnecrosis\tB-Disease\nfactor\tO\n-\tO\nalpha\tO\n(\tO\nTNFalpha\tO\n)\tO\n,\tO\nhippocampal\tO\nMT\tB-Chemical\nand\tO\nmalondialdehyde\tB-Chemical\n(\tO\nMDA\tB-Chemical\n)\tO\ncontents\tO\nas\tO\nwell\tO\nas\tO\ncaspase\tO\n-\tO\n3\tO\nactivity\tO\nin\tO\naddition\tO\nto\tO\nhistological\tO\nalterations\tO\n.\tO\n\nZnSO\tB-Chemical\n(\tI-Chemical\n4\tI-Chemical\n)\tI-Chemical\npretreatment\tO\ncounteracted\tO\nBCNU\tB-Chemical\n-\tO\ninduced\tO\ninhibition\tO\nof\tO\nGR\tO\nand\tO\ndepletion\tO\nof\tO\nGSH\tB-Chemical\nand\tO\nresulted\tO\nin\tO\nsignificant\tO\nreduction\tO\nin\tO\nthe\tO\nlevels\tO\nof\tO\nMDA\tB-Chemical\nand\tO\nTNFalpha\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\nactivity\tO\nof\tO\ncaspase\tO\n-\tO\n3\tO\n.\tO\n\nThe\tO\nhistological\tO\nfeatures\tO\nwere\tO\nimproved\tO\nin\tO\nhippocampus\tO\nof\tO\nrats\tO\ntreated\tO\nwith\tO\nZnSO\tB-Chemical\n(\tI-Chemical\n4\tI-Chemical\n)\tI-Chemical\n+\tO\nBCNU\tB-Chemical\ncompared\tO\nto\tO\nonly\tO\nBCNU\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nMT\tB-Chemical\ninduction\tO\nhalts\tO\nBCNU\tB-Chemical\n-\tO\ninduced\tO\nhippocampal\tO\ntoxicity\tB-Disease\nas\tO\nit\tO\nprevented\tO\nGR\tO\ninhibition\tO\nand\tO\nGSH\tB-Chemical\ndepletion\tO\nand\tO\ncounteracted\tO\nthe\tO\nincreased\tO\nlevels\tO\nof\tO\nTNFalpha\tO\n,\tO\nMDA\tB-Chemical\nand\tO\ncaspase\tO\n-\tO\n3\tO\nactivity\tO\nwith\tO\nsubsequent\tO\npreservation\tO\nof\tO\ncognition\tO\n.\tO\n\nFatal\tO\ncarbamazepine\tB-Chemical\ninduced\tO\nfulminant\tB-Disease\neosinophilic\tI-Disease\n(\tO\nhypersensitivity\tB-Disease\n)\tO\nmyocarditis\tB-Disease\n:\tO\nemphasis\tO\non\tO\nanatomical\tO\nand\tO\nhistological\tO\ncharacteristics\tO\n,\tO\nmechanisms\tO\nand\tO\ngenetics\tO\nof\tO\ndrug\tB-Disease\nhypersensitivity\tI-Disease\nand\tO\ndifferential\tO\ndiagnosis\tO\n.\tO\n\nThe\tO\nmost\tO\nsevere\tO\nadverse\tO\nreactions\tO\nto\tO\ncarbamazepine\tB-Chemical\nhave\tO\nbeen\tO\nobserved\tO\nin\tO\nthe\tO\nhaemopoietic\tO\nsystem\tO\n,\tO\nthe\tO\nliver\tO\nand\tO\nthe\tO\ncardiovascular\tO\nsystem\tO\n.\tO\n\nA\tO\nfrequently\tO\nfatal\tO\n,\tO\nalthough\tO\nexceptionally\tO\nrare\tO\nside\tO\neffect\tO\nof\tO\ncarbamazepine\tB-Chemical\nis\tO\nnecrotizing\tO\neosinophilic\tO\n(\tO\nhypersensitivity\tB-Disease\n)\tO\nmyocarditis\tB-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nhypersensitivity\tB-Disease\nmyocarditis\tB-Disease\nsecondary\tO\nto\tO\nadministration\tO\nof\tO\ncarbamazepine\tB-Chemical\n.\tO\n\nAcute\tO\nhypersensitivity\tB-Disease\nmyocarditis\tB-Disease\nwas\tO\nnot\tO\nsuspected\tO\nclinically\tO\n,\tO\nand\tO\nthe\tO\ndiagnosis\tO\nwas\tO\nmade\tO\npost\tO\n-\tO\nmortem\tO\n.\tO\n\nHistology\tO\nrevealed\tO\ndiffuse\tO\ninfiltration\tO\nof\tO\nthe\tO\nmyocardium\tO\nby\tO\neosinophils\tO\nand\tO\nlymphocytes\tO\nwith\tO\nmyocyte\tO\ndamage\tO\n.\tO\n\nClinically\tO\n,\tO\ndeath\tO\nwas\tO\ndue\tO\nto\tO\ncardiogenic\tB-Disease\nshock\tI-Disease\n.\tO\n\nTo\tO\nbest\tO\nof\tO\nour\tO\nknowledge\tO\nthis\tO\nis\tO\nthe\tO\nsecond\tO\ncase\tO\nof\tO\nfatal\tO\ncarbamazepine\tB-Chemical\ninduced\tO\nmyocarditis\tB-Disease\nreported\tO\nin\tO\nEnglish\tO\nliterature\tO\n.\tO\n\nNeuropsychiatric\tO\nbehaviors\tO\nin\tO\nthe\tO\nMPTP\tB-Chemical\nmarmoset\tO\nmodel\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nOBJECTIVES\tO\n:\tO\nNeuropsychiatric\tO\nsymptoms\tO\nare\tO\nincreasingly\tO\nrecognised\tO\nas\tO\na\tO\nsignificant\tO\nproblem\tO\nin\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\n.\tO\n\nThese\tO\nsymptoms\tO\nmay\tO\nbe\tO\ndue\tO\nto\tO\n'\tO\nsensitisation\tO\n'\tO\nfollowing\tO\nrepeated\tO\nlevodopa\tB-Chemical\ntreatment\tO\nor\tO\na\tO\ndirect\tO\neffect\tO\nof\tO\ndopamine\tB-Chemical\non\tO\nthe\tO\ndisease\tO\nstate\tO\n.\tO\n\nThe\tO\nlevodopa\tB-Chemical\n-\tO\ntreated\tO\nMPTP\tB-Chemical\n-\tO\nlesioned\tO\nmarmoset\tO\nwas\tO\nused\tO\nas\tO\na\tO\nmodel\tO\nof\tO\nneuropsychiatric\tB-Disease\nsymptoms\tI-Disease\nin\tO\nPD\tB-Disease\npatients\tO\n.\tO\n\nHere\tO\nwe\tO\ncompare\tO\nthe\tO\ntime\tO\ncourse\tO\nof\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\nmotor\tO\nfluctuations\tO\nand\tO\nneuropsychiatric\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nbehaviors\tI-Disease\nto\tO\ndetermine\tO\nthe\tO\nrelationship\tO\nbetween\tO\nduration\tO\nof\tO\ntreatment\tO\nand\tO\nonset\tO\nof\tO\nsymptoms\tO\n.\tO\n\nMETHODS\tO\n:\tO\nMarmosets\tO\nwere\tO\nadministered\tO\n1\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nphenyl\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\ntetrahydropyridine\tI-Chemical\n(\tO\n2\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nfor\tO\nfive\tO\ndays\tO\n,\tO\nresulting\tO\nin\tO\nstable\tO\nparkinsonism\tB-Disease\n.\tO\n\nLevodopa\tB-Chemical\n(\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\nand\tO\nbenserazide\tB-Chemical\n,\tO\n3\tO\n.\tO\n75\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\np\tO\n.\tO\no\tO\n.\tO\n\nb\tO\n.\tO\ni\tO\n.\tO\nd\tO\n,\tO\nwas\tO\nadministered\tO\nfor\tO\n30\tO\ndays\tO\n.\tO\n\nAnimals\tO\nwere\tO\nevaluated\tO\nfor\tO\nparkinsonian\tB-Disease\ndisability\tI-Disease\n,\tO\ndyskinesia\tB-Disease\nand\tO\non\tO\n-\tO\ntime\tO\n(\tO\nmotor\tO\nfluctuations\tO\n)\tO\nand\tO\nneuropsychiatric\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nbehaviors\tI-Disease\non\tO\nDay\tO\n0\tO\n(\tO\nprior\tO\nto\tO\nlevodopa\tB-Chemical\n)\tO\nand\tO\non\tO\nDays\tO\n1\tO\n,\tO\n7\tO\n,\tO\n13\tO\n,\tO\n27\tO\nand\tO\n30\tO\nof\tO\ntreatment\tO\nusing\tO\npost\tO\nhoc\tO\nDVD\tO\nanalysis\tO\nby\tO\na\tO\ntrained\tO\nrater\tO\n,\tO\nblind\tO\nto\tO\nthe\tO\ntreatment\tO\nday\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nneuropsychiatric\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nbehavior\tI-Disease\nrating\tO\nscale\tO\ndemonstrated\tO\nhigh\tO\ninterrater\tO\nreliability\tO\nbetween\tO\nthree\tO\ntrained\tO\nraters\tO\nof\tO\ndiffering\tO\nprofessional\tO\nbackgrounds\tO\n.\tO\n\nAs\tO\nanticipated\tO\n,\tO\nanimals\tO\nexhibited\tO\na\tO\nprogressive\tO\nincrease\tO\nin\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\nmotor\tO\nfluctuations\tO\n,\tO\ndyskinesia\tB-Disease\nand\tO\nwearing\tO\n-\tO\noff\tO\n,\tO\nthat\tO\ncorrelated\tO\nwith\tO\nthe\tO\nduration\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\nneuropsychiatric\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nbehaviors\tI-Disease\nwere\tO\npresent\tO\non\tO\nDay\tO\n1\tO\nof\tO\nlevodopa\tB-Chemical\ntreatment\tO\nand\tO\ntheir\tO\nseverity\tO\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nduration\tO\nof\tO\ntreatment\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ndata\tO\nsuggest\tO\nthat\tO\nneuropsychiatric\tB-Disease\ndisorders\tI-Disease\nin\tO\nPD\tB-Disease\nare\tO\nmore\tO\nlikely\tO\nan\tO\ninteraction\tO\nbetween\tO\nlevodopa\tB-Chemical\nand\tO\nthe\tO\ndisease\tO\nstate\tO\nthan\tO\na\tO\nconsequence\tO\nof\tO\nsensitisation\tO\nto\tO\nrepeated\tO\ndopaminergic\tO\ntherapy\tO\n.\tO\n\nContrast\tB-Chemical\nmedium\tI-Chemical\nnephrotoxicity\tB-Disease\nafter\tO\nrenal\tO\nartery\tO\nand\tO\ncoronary\tO\nangioplasty\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nRenal\tB-Disease\ndysfunction\tI-Disease\ninduced\tO\nby\tO\niodinated\tO\ncontrast\tB-Chemical\nmedium\tI-Chemical\n(\tO\nCM\tB-Chemical\n)\tO\nadministration\tO\ncan\tO\nminimize\tO\nthe\tO\nbenefit\tO\nof\tO\nthe\tO\ninterventional\tO\nprocedure\tO\nin\tO\npatients\tO\nundergoing\tO\nrenal\tO\nangioplasty\tO\n(\tO\nPTRA\tO\n)\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\ncompare\tO\nthe\tO\nsusceptibility\tO\nto\tO\nnephrotoxic\tB-Disease\neffect\tO\nof\tO\nCM\tB-Chemical\nin\tO\npatients\tO\nundergoing\tO\nPTRA\tO\nwith\tO\nthat\tO\nof\tO\npatients\tO\nsubmitted\tO\nto\tO\npercutaneous\tO\ncoronary\tO\nintervention\tO\n(\tO\nPCI\tO\n)\tO\n.\tO\n\nMATERIAL\tO\nAND\tO\nMETHODS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n33\tO\npatients\tO\nsuccessfully\tO\ntreated\tO\nwith\tO\nPTRA\tO\n(\tO\nPTRA\tO\ngroup\tO\n,\tO\nmean\tO\nage\tO\n70\tO\n+\tO\n/\tO\n-\tO\n12\tO\nyears\tO\n,\tO\n23\tO\nfemale\tO\n,\tO\nbasal\tO\ncreatinine\tB-Chemical\n1\tO\n.\tO\n46\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n79\tO\n,\tO\nrange\tO\n0\tO\n.\tO\n7\tO\n-\tO\n4\tO\n.\tO\n9\tO\nmg\tO\n/\tO\ndl\tO\n)\tO\nwere\tO\ncompared\tO\nwith\tO\n33\tO\npatients\tO\nundergoing\tO\nsuccessful\tO\nPCI\tO\n(\tO\nPCI\tO\ngroup\tO\n)\tO\n,\tO\nmatched\tO\nfor\tO\nbasal\tO\ncreatinine\tB-Chemical\n(\tO\n1\tO\n.\tO\n44\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n6\tO\n,\tO\nrange\tO\n0\tO\n.\tO\n7\tO\n-\tO\n3\tO\n.\tO\n4\tO\nmg\tO\n/\tO\ndl\tO\n)\tO\n,\tO\ngender\tO\n,\tO\nand\tO\nage\tO\n.\tO\n\nIn\tO\nboth\tO\ngroups\tO\npostprocedural\tO\n(\tO\n48\tO\nh\tO\n)\tO\nserum\tO\ncreatinine\tB-Chemical\nwas\tO\nmeasured\tO\n.\tO\n\nRESULTS\tO\n:\tO\nPostprocedural\tO\ncreatinine\tB-Chemical\nlevel\tO\ndecreased\tO\nnonsignificantly\tO\nin\tO\nthe\tO\nPTRA\tO\ngroup\tO\n(\tO\n1\tO\n.\tO\n46\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n8\tO\nvs\tO\n.\tO\n1\tO\n.\tO\n34\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nP\tO\n=\tO\nNS\tO\n)\tO\nand\tO\nincreased\tO\nsignificantly\tO\nin\tO\nthe\tO\nPCI\tO\ngroup\tO\n(\tO\n1\tO\n.\tO\n44\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n6\tO\nvs\tO\n.\tO\n1\tO\n.\tO\n57\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nChanges\tO\nin\tO\nserum\tO\ncreatinine\tB-Chemical\nafter\tO\nintervention\tO\n(\tO\nafter\tO\n-\tO\nbefore\tO\n)\tO\nwere\tO\nsignificantly\tO\ndifferent\tO\nbetween\tO\nthe\tO\nPTRA\tO\nand\tO\nPCI\tO\ngroups\tO\n(\tO\n-\tO\n0\tO\n.\tO\n12\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n5\tO\nvs\tO\n.\tO\n0\tO\n.\tO\n13\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n3\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n014\tO\n)\tO\n.\tO\n\nThis\tO\ndifference\tO\nwas\tO\nnot\tO\nrelated\tO\nto\tO\neither\tO\na\tO\ndifferent\tO\nclinical\tO\nrisk\tO\nprofile\tO\nor\tO\nto\tO\nthe\tO\nvolume\tO\nof\tO\nCM\tB-Chemical\nadministered\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\nthis\tO\npreliminary\tO\nstudy\tO\npatients\tO\nsubmitted\tO\nto\tO\nPTRA\tO\nshowed\tO\na\tO\nlower\tO\nsusceptibility\tO\nto\tO\nrenal\tB-Disease\ndamage\tI-Disease\ninduced\tO\nby\tO\nCM\tB-Chemical\nadministration\tO\nthan\tO\nPCI\tO\npatients\tO\n.\tO\n\nThe\tO\neffectiveness\tO\nof\tO\nPTRA\tO\non\tO\nrenal\tO\nfunction\tO\nseems\tO\nto\tO\nbe\tO\nbarely\tO\ninfluenced\tO\nby\tO\nCM\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nDiphenhydramine\tB-Chemical\nprevents\tO\nthe\tO\nhaemodynamic\tO\nchanges\tO\nof\tO\ncimetidine\tB-Chemical\nin\tO\nICU\tO\npatients\tO\n.\tO\n\nCimetidine\tB-Chemical\n,\tO\na\tO\nhistamine\tB-Chemical\n2\tO\n(\tO\nH2\tO\n)\tO\nantagonist\tO\n,\tO\nproduces\tO\na\tO\ndecrease\tO\nin\tO\narterial\tO\npressure\tO\ndue\tO\nto\tO\nvasodilatation\tO\n,\tO\nespecially\tO\nin\tO\ncritically\tO\nill\tO\npatients\tO\n.\tO\n\nThis\tO\nmay\tO\nbe\tO\nbecause\tO\ncimetidine\tB-Chemical\nacts\tO\nas\tO\na\tO\nhistamine\tB-Chemical\nagonist\tO\n.\tO\n\nWe\tO\n,\tO\ntherefore\tO\n,\tO\ninvestigated\tO\nthe\tO\neffects\tO\nof\tO\nthe\tO\nhistamine\tB-Chemical\n1\tO\n(\tO\nH1\tO\n)\tO\nreceptor\tO\nantagonist\tO\n,\tO\ndiphenhydramine\tB-Chemical\n,\tO\non\tO\nthe\tO\nhaemodynamic\tO\nchanges\tO\nobserved\tO\nafter\tO\ncimetidine\tB-Chemical\nin\tO\nICU\tO\npatients\tO\n.\tO\n\nEach\tO\npatient\tO\nwas\tO\nstudied\tO\non\tO\ntwo\tO\nseparate\tO\ndays\tO\n.\tO\n\nIn\tO\na\tO\nrandom\tO\nfashion\tO\n,\tO\nthey\tO\nreceived\tO\ncimetidine\tB-Chemical\n200\tO\nmg\tO\niv\tO\non\tO\none\tO\nday\tO\n,\tO\nand\tO\non\tO\nthe\tO\nother\tO\n,\tO\na\tO\npretreatment\tO\nof\tO\ndiphenhydramine\tB-Chemical\n40\tO\nmg\tO\niv\tO\nwith\tO\ncimetidine\tB-Chemical\n200\tO\nmg\tO\niv\tO\n.\tO\n\nIn\tO\nthe\tO\nnon\tO\n-\tO\npretreatment\tO\ngroup\tO\n,\tO\nmean\tO\narterial\tO\npressure\tO\n(\tO\nMAP\tO\n)\tO\ndecreased\tO\nfrom\tO\n107\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n8\tO\n.\tO\n4\tO\nmmHg\tO\nto\tO\n86\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n11\tO\n.\tO\n4\tO\nmmHg\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\ntwo\tO\nminutes\tO\nafter\tO\ncimetidine\tB-Chemical\n.\tO\n\nAlso\tO\n,\tO\nsystemic\tO\nvascular\tO\nresistance\tO\n(\tO\nSVR\tO\n)\tO\ndecreased\tO\nduring\tO\nthe\tO\neight\tO\n-\tO\nminute\tO\nobservation\tO\nperiod\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nin\tO\nthe\tO\npretreatment\tO\ngroup\tO\n,\tO\nlittle\tO\nhaemodynamic\tO\nchange\tO\nwas\tO\nseen\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nan\tO\nH1\tO\nantagonist\tO\nmay\tO\nbe\tO\nuseful\tO\nin\tO\npreventing\tO\nhypotension\tB-Disease\ncaused\tO\nby\tO\niv\tO\ncimetidine\tB-Chemical\n,\tO\nsince\tO\nthe\tO\nvasodilating\tO\nactivity\tO\nof\tO\ncimetidine\tB-Chemical\nis\tO\nmediated\tO\n,\tO\nin\tO\npart\tO\n,\tO\nthrough\tO\nthe\tO\nH1\tO\nreceptor\tO\n.\tO\n\nMedical\tO\nand\tO\npsychiatric\tO\noutcomes\tO\nfor\tO\npatients\tO\ntransplanted\tO\nfor\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n:\tO\na\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAcetaminophen\tB-Chemical\n-\tO\ninduced\tO\nhepatotoxicity\tB-Disease\nis\tO\nthe\tO\nmost\tO\ncommon\tO\ncause\tO\nof\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n(\tO\nALF\tB-Disease\n)\tO\nin\tO\nthe\tO\nUK\tO\n.\tO\n\nPatients\tO\noften\tO\nconsume\tO\nthe\tO\ndrug\tO\nwith\tO\nsuicidal\tO\nintent\tO\nor\tO\nwith\tO\na\tO\nbackground\tO\nof\tO\nsubstance\tO\ndependence\tO\n.\tO\n\nAIMS\tO\nAND\tO\nMETHODS\tO\n:\tO\nWe\tO\ncompared\tO\nthe\tO\nseverity\tO\nof\tO\npretransplant\tO\nillness\tO\n,\tO\npsychiatric\tO\nco\tO\n-\tO\nmorbidity\tO\n,\tO\nmedical\tO\nand\tO\npsychosocial\tO\noutcomes\tO\nof\tO\nall\tO\npatients\tO\nwho\tO\nhad\tO\nundergone\tO\nliver\tO\ntransplantation\tO\n(\tO\nLT\tO\n)\tO\nemergently\tO\nbetween\tO\n1999\tO\n-\tO\n2004\tO\nfor\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\n(\tO\nn\tO\n=\tO\n36\tO\n)\tO\nwith\tO\nage\tO\n-\tO\nand\tO\nsex\tO\n-\tO\nmatched\tO\npatients\tO\nundergoing\tO\nemergent\tO\nLT\tO\nfor\tO\nnon\tO\n-\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\n(\tO\nn\tO\n=\tO\n35\tO\n)\tO\nand\tO\nelective\tO\nLT\tO\nfor\tO\nchronic\tB-Disease\nliver\tI-Disease\ndisease\tI-Disease\n(\tO\nCLD\tB-Disease\n,\tO\nn\tO\n=\tO\n34\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAcetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\npatients\tO\nundergoing\tO\nLT\tO\nhad\tO\na\tO\ngreater\tO\nseverity\tO\nof\tO\npre\tO\n-\tO\nLT\tO\nillness\tO\nreflected\tO\nby\tO\nhigher\tO\nAcute\tO\nPhysiology\tO\nand\tO\nChronic\tO\nHealth\tO\nEvaluation\tO\nII\tO\nscores\tO\nand\tO\nrequirement\tO\nfor\tO\norgan\tO\nsupport\tO\ncompared\tO\nwith\tO\nthe\tO\nother\tO\ntwo\tO\ngroups\tO\n.\tO\n\nTwenty\tO\n(\tO\n56\tO\n%\tO\n)\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\npatients\tO\nhad\tO\na\tO\nformal\tO\npsychiatric\tO\ndiagnosis\tO\nbefore\tO\nLT\tO\n(\tO\nnon\tO\n-\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\n=\tO\n0\tO\n/\tO\n35\tO\n,\tO\nCLD\tB-Disease\n=\tO\n2\tO\n/\tO\n34\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\nfor\tO\nall\tO\n)\tO\nand\tO\nnine\tO\n(\tO\n25\tO\n%\tO\n)\tO\nhad\tO\na\tO\nprevious\tO\nsuicide\tO\nattempt\tO\n.\tO\n\nDuring\tO\nfollow\tO\n-\tO\nup\tO\n(\tO\nmedian\tO\n5\tO\nyears\tO\n)\tO\n,\tO\nthere\tO\nwere\tO\nno\tO\nsignificant\tO\ndifferences\tO\nin\tO\nrejection\tO\n(\tO\nacute\tO\nand\tO\nchronic\tO\n)\tO\n,\tO\ngraft\tO\nfailure\tO\nor\tO\nsurvival\tO\nbetween\tO\nthe\tO\ngroups\tO\n(\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\n1\tO\nyear\tO\n87\tO\n%\tO\n,\tO\n5\tO\nyears\tO\n75\tO\n%\tO\n;\tO\nnon\tO\n-\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\n88\tO\n%\tO\n,\tO\n78\tO\n%\tO\n;\tO\nCLD\tB-Disease\n93\tO\n%\tO\n,\tO\n82\tO\n%\tO\n:\tO\nP\tO\n>\tO\n0\tO\n.\tO\n6\tO\nlog\tO\nrank\tO\n)\tO\n.\tO\n\nTwo\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\npatients\tO\nreattempted\tO\nsuicide\tO\npost\tO\n-\tO\nLT\tO\n(\tO\none\tO\ndied\tO\n8\tO\nyears\tO\npost\tO\n-\tO\nLT\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDespite\tO\na\tO\nhigh\tO\nprevalence\tO\nof\tO\npsychiatric\tO\ndisturbance\tO\n,\tO\noutcomes\tO\nfor\tO\npatients\tO\ntransplanted\tO\nemergently\tO\nfor\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\nwere\tO\ncomparable\tO\nto\tO\nthose\tO\ntransplanted\tO\nfor\tO\nnon\tO\n-\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nALF\tB-Disease\nand\tO\nelectively\tO\nfor\tO\nCLD\tB-Disease\n.\tO\n\nMultidisciplinary\tO\napproaches\tO\nwith\tO\nlong\tO\n-\tO\nterm\tO\npsychiatric\tO\nfollow\tO\n-\tO\nup\tO\nmay\tO\ncontribute\tO\nto\tO\nlow\tO\npost\tO\n-\tO\ntransplant\tO\nsuicide\tO\nrates\tO\nseen\tO\nand\tO\nlow\tO\nrates\tO\nof\tO\ngraft\tO\nloss\tO\nbecause\tO\nof\tO\nnon\tO\n-\tO\ncompliance\tO\n.\tO\n\nAntithrombotic\tO\ndrug\tO\nuse\tO\n,\tO\ncerebral\tB-Disease\nmicrobleeds\tI-Disease\n,\tO\nand\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n:\tO\na\tO\nsystematic\tO\nreview\tO\nof\tO\npublished\tO\nand\tO\nunpublished\tO\nstudies\tO\n.\tO\n\nBACKGROUND\tO\nAND\tO\nPURPOSE\tO\n:\tO\nCerebral\tB-Disease\nmicrobleeds\tI-Disease\n(\tO\nMB\tB-Disease\n)\tO\nare\tO\npotential\tO\nrisk\tO\nfactors\tO\nfor\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n(\tO\nICH\tB-Disease\n)\tO\n,\tO\nbut\tO\nit\tO\nis\tO\nunclear\tO\nif\tO\nthey\tO\nare\tO\na\tO\ncontraindication\tO\nto\tO\nusing\tO\nantithrombotic\tO\ndrugs\tO\n.\tO\n\nInsights\tO\ncould\tO\nbe\tO\ngained\tO\nby\tO\npooling\tO\ndata\tO\non\tO\nMB\tB-Disease\nfrequency\tO\nstratified\tO\nby\tO\nantithrombotic\tO\nuse\tO\nin\tO\ncohorts\tO\nwith\tO\nICH\tB-Disease\nand\tO\nischemic\tB-Disease\nstroke\tI-Disease\n(\tO\nIS\tB-Disease\n)\tO\n/\tO\ntransient\tB-Disease\nischemic\tI-Disease\nattack\tI-Disease\n(\tO\nTIA\tB-Disease\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nperformed\tO\na\tO\nsystematic\tO\nreview\tO\nof\tO\npublished\tO\nand\tO\nunpublished\tO\ndata\tO\nfrom\tO\ncohorts\tO\nwith\tO\nstroke\tB-Disease\nor\tO\nTIA\tB-Disease\nto\tO\ncompare\tO\nthe\tO\npresence\tO\nof\tO\nMB\tB-Disease\nin\tO\n:\tO\n(\tO\n1\tO\n)\tO\nantithrombotic\tO\nusers\tO\nvs\tO\nnonantithrombotic\tO\nusers\tO\nwith\tO\nICH\tB-Disease\n;\tO\n(\tO\n2\tO\n)\tO\nantithrombotic\tO\nusers\tO\nvs\tO\nnonusers\tO\nwith\tO\nIS\tB-Disease\n/\tO\nTIA\tB-Disease\n;\tO\nand\tO\n(\tO\n3\tO\n)\tO\nICH\tB-Disease\nvs\tO\nischemic\tB-Disease\nevents\tO\nstratified\tO\nby\tO\nantithrombotic\tO\nuse\tO\n.\tO\n\nWe\tO\nalso\tO\nanalyzed\tO\npublished\tO\nand\tO\nunpublished\tO\nfollow\tO\n-\tO\nup\tO\ndata\tO\nto\tO\ndetermine\tO\nthe\tO\nrisk\tO\nof\tO\nICH\tB-Disease\nin\tO\nantithrombotic\tO\nusers\tO\nwith\tO\nMB\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nIn\tO\na\tO\npooled\tO\nanalysis\tO\nof\tO\n1460\tO\nICH\tB-Disease\nand\tO\n3817\tO\nIS\tB-Disease\n/\tO\nTIA\tB-Disease\n,\tO\nMB\tB-Disease\nwere\tO\nmore\tO\nfrequent\tO\nin\tO\nICH\tB-Disease\nvs\tO\nIS\tB-Disease\n/\tO\nTIA\tB-Disease\nin\tO\nall\tO\ntreatment\tO\ngroups\tO\n,\tO\nbut\tO\nthe\tO\nexcess\tO\nincreased\tO\nfrom\tO\n2\tO\n.\tO\n8\tO\n(\tO\nodds\tO\nratio\tO\n;\tO\nrange\tO\n,\tO\n2\tO\n.\tO\n3\tO\n-\tO\n3\tO\n.\tO\n5\tO\n)\tO\nin\tO\nnonantithrombotic\tO\nusers\tO\nto\tO\n5\tO\n.\tO\n7\tO\n(\tO\nrange\tO\n,\tO\n3\tO\n.\tO\n4\tO\n-\tO\n9\tO\n.\tO\n7\tO\n)\tO\nin\tO\nantiplatelet\tO\nusers\tO\nand\tO\n8\tO\n.\tO\n0\tO\n(\tO\nrange\tO\n,\tO\n3\tO\n.\tO\n5\tO\n-\tO\n17\tO\n.\tO\n8\tO\n)\tO\nin\tO\nwarfarin\tB-Chemical\nusers\tO\n(\tO\nP\tO\ndifference\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\nalso\tO\nan\tO\nexcess\tO\nof\tO\nMB\tB-Disease\nin\tO\nwarfarin\tB-Chemical\nusers\tO\nvs\tO\nnonusers\tO\nwith\tO\nICH\tB-Disease\n(\tO\nOR\tO\n,\tO\n2\tO\n.\tO\n7\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n6\tO\n-\tO\n4\tO\n.\tO\n4\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nbut\tO\nnone\tO\nin\tO\nwarfarin\tB-Chemical\nusers\tO\nwith\tO\nIS\tB-Disease\n/\tO\nTIA\tB-Disease\n(\tO\nOR\tO\n,\tO\n1\tO\n.\tO\n3\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n0\tO\n.\tO\n9\tO\n-\tO\n1\tO\n.\tO\n7\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n33\tO\n;\tO\nP\tO\ndifference\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsmaller\tO\nexcess\tO\nof\tO\nMB\tB-Disease\nin\tO\nantiplatelet\tO\nusers\tO\nvs\tO\nnonusers\tO\nwith\tO\nICH\tB-Disease\n(\tO\nOR\tO\n,\tO\n1\tO\n.\tO\n7\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n3\tO\n-\tO\n2\tO\n.\tO\n3\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nbut\tO\nfindings\tO\nwere\tO\nsimilar\tO\nfor\tO\nantiplatelet\tO\nusers\tO\nwith\tO\nIS\tB-Disease\n/\tO\nTIA\tB-Disease\n(\tO\nOR\tO\n,\tO\n1\tO\n.\tO\n4\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n2\tO\n-\tO\n1\tO\n.\tO\n7\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n;\tO\nP\tO\ndifference\tO\n=\tO\n0\tO\n.\tO\n25\tO\n)\tO\n.\tO\n\nIn\tO\npooled\tO\nfollow\tO\n-\tO\nup\tO\ndata\tO\nfor\tO\n768\tO\nantithrombotic\tO\nusers\tO\n,\tO\npresence\tO\nof\tO\nMB\tB-Disease\nat\tO\nbaseline\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nsubstantially\tO\nincreased\tO\nrisk\tO\nof\tO\nsubsequent\tO\nICH\tB-Disease\n(\tO\nOR\tO\n,\tO\n12\tO\n.\tO\n1\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n3\tO\n.\tO\n4\tO\n-\tO\n42\tO\n.\tO\n5\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nexcess\tO\nof\tO\nMB\tB-Disease\nin\tO\nwarfarin\tB-Chemical\nusers\tO\nwith\tO\nICH\tB-Disease\ncompared\tO\nto\tO\nother\tO\ngroups\tO\nsuggests\tO\nthat\tO\nMB\tB-Disease\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nwarfarin\tB-Chemical\n-\tO\nassociated\tO\nICH\tB-Disease\n.\tO\n\nLimited\tO\nprospective\tO\ndata\tO\ncorroborate\tO\nthese\tO\nfindings\tO\n,\tO\nbut\tO\nlarger\tO\nprospective\tO\nstudies\tO\nare\tO\nurgently\tO\nrequired\tO\n.\tO\n\nStudies\tO\nof\tO\nsynergy\tO\nbetween\tO\nmorphine\tB-Chemical\nand\tO\na\tO\nnovel\tO\nsodium\tB-Chemical\nchannel\tO\nblocker\tO\n,\tO\nCNSB002\tB-Chemical\n,\tO\nin\tO\nrat\tO\nmodels\tO\nof\tO\ninflammatory\tO\nand\tO\nneuropathic\tB-Disease\npain\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThis\tO\nstudy\tO\ndetermined\tO\nthe\tO\nantihyperalgesic\tO\neffect\tO\nof\tO\nCNSB002\tB-Chemical\n,\tO\na\tO\nsodium\tB-Chemical\nchannel\tO\nblocker\tO\nwith\tO\nantioxidant\tO\nproperties\tO\ngiven\tO\nalone\tO\nand\tO\nin\tO\ncombinations\tO\nwith\tO\nmorphine\tB-Chemical\nin\tO\nrat\tO\nmodels\tO\nof\tO\ninflammatory\tO\nand\tO\nneuropathic\tB-Disease\npain\tI-Disease\n.\tO\n\nDESIGN\tO\n:\tO\nDose\tO\nresponse\tO\ncurves\tO\nfor\tO\nnonsedating\tO\ndoses\tO\nof\tO\nmorphine\tB-Chemical\nand\tO\nCNSB002\tB-Chemical\ngiven\tO\nintraperitoneally\tO\nalone\tO\nand\tO\ntogether\tO\nin\tO\ncombinations\tO\nwere\tO\nconstructed\tO\nfor\tO\nantihyperalgesic\tO\neffect\tO\nusing\tO\npaw\tO\nwithdrawal\tO\nfrom\tO\nnoxious\tO\nheat\tO\nin\tO\ntwo\tO\nrat\tO\npain\tB-Disease\nmodels\tO\n:\tO\ncarrageenan\tB-Chemical\n-\tO\ninduced\tO\npaw\tO\ninflammation\tB-Disease\nand\tO\nstreptozotocin\tB-Chemical\n(\tO\nSTZ\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ndiabetic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nmaximum\tO\nnonsedating\tO\ndoses\tO\nwere\tO\n:\tO\nmorphine\tB-Chemical\n,\tO\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n;\tO\nCNSB002\tB-Chemical\n10\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n;\tO\n5\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nCNSB002\tB-Chemical\nwith\tO\nmorphine\tB-Chemical\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nin\tO\ncombination\tO\n.\tO\n\nThe\tO\ndoses\tO\ncalculated\tO\nto\tO\ncause\tO\n50\tO\n%\tO\nreversal\tO\nof\tO\nhyperalgesia\tB-Disease\n(\tO\nED50\tO\n)\tO\nwere\tO\n7\tO\n.\tO\n54\tO\n(\tO\n1\tO\n.\tO\n81\tO\n)\tO\nand\tO\n4\tO\n.\tO\n83\tO\n(\tO\n1\tO\n.\tO\n54\tO\n)\tO\nin\tO\nthe\tO\ncarrageenan\tB-Chemical\nmodel\tO\nand\tO\n44\tO\n.\tO\n18\tO\n(\tO\n1\tO\n.\tO\n37\tO\n)\tO\nand\tO\n9\tO\n.\tO\n14\tO\n(\tO\n1\tO\n.\tO\n24\tO\n)\tO\nin\tO\nthe\tO\nSTZ\tB-Chemical\n-\tO\ninduced\tO\nneuropathy\tB-Disease\nmodel\tO\nfor\tO\nCNSB002\tB-Chemical\nand\tO\nmorphine\tB-Chemical\n,\tO\nrespectively\tO\n(\tO\nmg\tO\n/\tO\nkg\tO\n;\tO\nmean\tO\n,\tO\nSEM\tO\n)\tO\n.\tO\n\nThese\tO\nvalues\tO\nwere\tO\ngreater\tO\nthan\tO\nthe\tO\nmaximum\tO\nnonsedating\tO\ndoses\tO\n.\tO\n\nThe\tO\nED50\tO\nvalues\tO\nfor\tO\nmorphine\tB-Chemical\nwhen\tO\ngiven\tO\nin\tO\ncombination\tO\nwith\tO\nCNSB002\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwere\tO\nless\tO\nthan\tO\nthe\tO\nmaximum\tO\nnonsedating\tO\ndose\tO\n:\tO\n0\tO\n.\tO\n56\tO\n(\tO\n1\tO\n.\tO\n55\tO\n)\tO\nin\tO\nthe\tO\ncarrageenan\tB-Chemical\nmodel\tO\nand\tO\n1\tO\n.\tO\n37\tO\n(\tO\n1\tO\n.\tO\n23\tO\n)\tO\nin\tO\nthe\tO\nneuropathy\tB-Disease\nmodel\tO\n(\tO\nmg\tO\n/\tO\nkg\tO\n;\tO\nmean\tO\n,\tO\nSEM\tO\n)\tO\n.\tO\n\nThe\tO\nantinociception\tO\nafter\tO\nmorphine\tB-Chemical\n(\tO\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\nincreased\tO\nby\tO\nco\tO\n-\tO\nadministration\tO\nwith\tO\nCNSB002\tB-Chemical\nfrom\tO\n28\tO\n.\tO\n0\tO\nand\tO\n31\tO\n.\tO\n7\tO\n%\tO\nto\tO\n114\tO\n.\tO\n6\tO\nand\tO\n56\tO\n.\tO\n9\tO\n%\tO\nreversal\tO\nof\tO\nhyperalgesia\tB-Disease\nin\tO\nthe\tO\ninflammatory\tO\nand\tO\nneuropathic\tB-Disease\nmodels\tO\n,\tO\nrespectively\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n;\tO\none\tO\n-\tO\nway\tO\nanalysis\tO\nof\tO\nvariance\tO\n-\tO\nsignificantly\tO\ngreater\tO\nthan\tO\neither\tO\ndrug\tO\ngiven\tO\nalone\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nmaximum\tO\nantihyperalgesic\tO\neffect\tO\nachievable\tO\nwith\tO\nnonsedating\tO\ndoses\tO\nof\tO\nmorphine\tB-Chemical\nmay\tO\nbe\tO\nincreased\tO\nsignificantly\tO\nwhen\tO\nthe\tO\ndrug\tO\nis\tO\nused\tO\nin\tO\ncombination\tO\nwith\tO\nCNSB002\tB-Chemical\n.\tO\n\nHeparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n:\tO\na\tO\npractical\tO\nreview\tO\n.\tO\n\nHeparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n(\tO\nHIT\tB-Disease\n)\tO\nremains\tO\nunder\tO\n-\tO\nrecognized\tO\ndespite\tO\nits\tO\npotentially\tO\ndevastating\tO\noutcomes\tO\n.\tO\n\nIt\tO\nbegins\tO\nwhen\tO\nheparin\tB-Chemical\nexposure\tO\nstimulates\tO\nthe\tO\nformation\tO\nof\tO\nheparin\tB-Chemical\n-\tO\nplatelet\tO\nfactor\tO\n4\tO\nantibodies\tO\n,\tO\nwhich\tO\nin\tO\nturn\tO\ntriggers\tO\nthe\tO\nrelease\tO\nof\tO\nprocoagulant\tO\nplatelet\tO\nparticles\tO\n.\tO\n\nThrombosis\tB-Disease\nand\tO\nthrombocytopenia\tB-Disease\nthat\tO\nfollow\tO\ncomprise\tO\nthe\tO\n2\tO\nhallmark\tO\ntraits\tO\nof\tO\nHIT\tB-Disease\n,\tO\nwith\tO\nthe\tO\nformer\tO\nlargely\tO\nresponsible\tO\nfor\tO\nsignificant\tO\nvascular\tO\ncomplications\tO\n.\tO\n\nThe\tO\nprevalence\tO\nof\tO\nHIT\tB-Disease\nvaries\tO\namong\tO\nseveral\tO\nsubgroups\tO\n,\tO\nwith\tO\ngreater\tO\nincidence\tO\nin\tO\nsurgical\tO\nas\tO\ncompared\tO\nwith\tO\nmedical\tO\npopulations\tO\n.\tO\n\nHIT\tB-Disease\nmust\tO\nbe\tO\nacknowledged\tO\nfor\tO\nits\tO\nintense\tO\npredilection\tO\nfor\tO\nthrombosis\tB-Disease\nand\tO\nsuspected\tO\nwhenever\tO\nthrombosis\tB-Disease\noccurs\tO\nafter\tO\nheparin\tB-Chemical\nexposure\tO\n.\tO\n\nEarly\tO\nrecognition\tO\nthat\tO\nincorporates\tO\nthe\tO\nclinical\tO\nand\tO\nserologic\tO\nclues\tO\nis\tO\nparamount\tO\nto\tO\ntimely\tO\ninstitution\tO\nof\tO\ntreatment\tO\n,\tO\nas\tO\nits\tO\ndelay\tO\nmay\tO\nresult\tO\nin\tO\ncatastrophic\tO\noutcomes\tO\n.\tO\n\nThe\tO\ntreatment\tO\nof\tO\nHIT\tB-Disease\nmandates\tO\nan\tO\nimmediate\tO\ncessation\tO\nof\tO\nall\tO\nheparin\tB-Chemical\nexposure\tO\nand\tO\nthe\tO\ninstitution\tO\nof\tO\nan\tO\nantithrombotic\tO\ntherapy\tO\n,\tO\nmost\tO\ncommonly\tO\nusing\tO\na\tO\ndirect\tB-Chemical\nthrombin\tI-Chemical\ninhibitor\tI-Chemical\n.\tO\n\nCurrent\tO\n\"\tO\ndiagnostic\tO\n\"\tO\ntests\tO\n,\tO\nwhich\tO\nprimarily\tO\ninclude\tO\nfunctional\tO\nand\tO\nantigenic\tO\nassays\tO\n,\tO\nhave\tO\nmore\tO\nof\tO\na\tO\nconfirmatory\tO\nthan\tO\ndiagnostic\tO\nrole\tO\nin\tO\nthe\tO\nmanagement\tO\nof\tO\nHIT\tB-Disease\n.\tO\n\nSpecial\tO\nattention\tO\nmust\tO\nbe\tO\npaid\tO\nto\tO\ncardiac\tO\npatients\tO\nwho\tO\nare\tO\noften\tO\nexposed\tO\nto\tO\nheparin\tB-Chemical\nmultiple\tO\ntimes\tO\nduring\tO\ntheir\tO\ncourse\tO\nof\tO\ntreatment\tO\n.\tO\n\nDirect\tB-Chemical\nthrombin\tI-Chemical\ninhibitors\tI-Chemical\nare\tO\nappropriate\tO\n,\tO\nevidence\tO\n-\tO\nbased\tO\nalternatives\tO\nto\tO\nheparin\tB-Chemical\nin\tO\npatients\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nHIT\tB-Disease\n,\tO\nwho\tO\nneed\tO\nto\tO\nundergo\tO\npercutaneous\tO\ncoronary\tO\nintervention\tO\n.\tO\n\nAs\tO\nheparin\tB-Chemical\nremains\tO\none\tO\nof\tO\nthe\tO\nmost\tO\nfrequently\tO\nused\tO\nmedications\tO\ntoday\tO\nwith\tO\npotential\tO\nfor\tO\nHIT\tB-Disease\nwith\tO\nevery\tO\nheparin\tB-Chemical\nexposure\tO\n,\tO\na\tO\nclose\tO\nvigilance\tO\nof\tO\nplatelet\tO\ncounts\tO\nmust\tO\nbe\tO\npracticed\tO\nwhenever\tO\nheparin\tB-Chemical\nis\tO\ninitiated\tO\n.\tO\n\nAbductor\tO\nparalysis\tB-Disease\nafter\tO\nbotox\tB-Chemical\ninjection\tO\nfor\tO\nadductor\tB-Disease\nspasmodic\tI-Disease\ndysphonia\tI-Disease\n.\tO\n\nOBJECTIVES\tO\n/\tO\nHYPOTHESIS\tO\n:\tO\nBotulinum\tO\ntoxin\tO\n(\tO\nBotox\tB-Chemical\n)\tO\ninjections\tO\ninto\tO\nthe\tO\nthyroarytenoid\tO\nmuscles\tO\nare\tO\nthe\tO\ncurrent\tO\nstandard\tO\nof\tO\ncare\tO\nfor\tO\nadductor\tB-Disease\nspasmodic\tI-Disease\ndysphonia\tI-Disease\n(\tO\nADSD\tB-Disease\n)\tO\n.\tO\n\nReported\tO\nadverse\tO\neffects\tO\ninclude\tO\na\tO\nperiod\tO\nof\tO\nbreathiness\tO\n,\tO\nthroat\tB-Disease\npain\tI-Disease\n,\tO\nand\tO\ndifficulty\tO\nwith\tO\nswallowing\tO\nliquids\tO\n.\tO\n\nHere\tO\nwe\tO\nreport\tO\nmultiple\tO\ncases\tO\nof\tO\nbilateral\tO\nabductor\tO\nparalysis\tB-Disease\nfollowing\tO\nBotox\tB-Chemical\ninjections\tO\nfor\tO\nADSD\tB-Disease\n,\tO\na\tO\ncomplication\tO\npreviously\tO\nunreported\tO\n.\tO\n\nSTUDY\tO\nDESIGN\tO\n:\tO\nRetrospective\tO\ncase\tO\nseries\tO\n.\tO\n\nMETHODS\tO\n:\tO\nPatients\tO\nthat\tO\nreceived\tO\nBotox\tB-Chemical\ninjections\tO\nfor\tO\nspasmodic\tB-Disease\ndysphonia\tI-Disease\nbetween\tO\nJanuary\tO\n2000\tO\nand\tO\nOctober\tO\n2009\tO\nwere\tO\nevaluated\tO\n.\tO\n\nPatients\tO\nwith\tO\nADSD\tB-Disease\nwere\tO\nidentified\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\ntreatments\tO\nreceived\tO\nand\tO\nadverse\tO\neffects\tO\nwere\tO\nnoted\tO\n.\tO\n\nFor\tO\npatients\tO\nwith\tO\nbilateral\tO\nabductor\tO\nparalysis\tB-Disease\n,\tO\nage\tO\n,\tO\nsex\tO\n,\tO\nparalytic\tO\nBotox\tB-Chemical\ndose\tO\n,\tO\nprior\tO\nBotox\tB-Chemical\ndose\tO\n,\tO\nand\tO\ncourse\tO\nfollowing\tO\nparalysis\tB-Disease\nwere\tO\nnoted\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFrom\tO\na\tO\ndatabase\tO\nof\tO\n452\tO\npatients\tO\nreceiving\tO\nBotox\tB-Chemical\n,\tO\n352\tO\npatients\tO\nhad\tO\nbeen\tO\ndiagnosed\tO\nwith\tO\nADSD\tB-Disease\n.\tO\n\nOf\tO\nthese\tO\n352\tO\npatients\tO\n,\tO\neight\tO\npatients\tO\nsuffered\tO\nbilateral\tO\nabductor\tO\nparalysis\tB-Disease\n,\tO\nand\tO\ntwo\tO\nsuffered\tO\nthis\tO\ncomplication\tO\ntwice\tO\n.\tO\n\nAll\tO\naffected\tO\npatients\tO\nwere\tO\nfemales\tO\nover\tO\nthe\tO\nage\tO\nof\tO\n50\tO\nyears\tO\n.\tO\n\nMost\tO\npatients\tO\nhad\tO\nreceived\tO\ntreatments\tO\nprior\tO\nto\tO\nabductor\tO\nparalysis\tB-Disease\nand\tO\ncontinued\tO\nreceiving\tO\nafter\tO\nparalysis\tB-Disease\n.\tO\n\nSeven\tO\npatients\tO\nrecovered\tO\nafter\tO\na\tO\nbrief\tO\nperiod\tO\nof\tO\nactivity\tO\nrestrictions\tO\n,\tO\nand\tO\none\tO\nunderwent\tO\na\tO\ntracheotomy\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nabductor\tO\nparalysis\tB-Disease\nafter\tO\nBotox\tB-Chemical\ninjection\tO\nfor\tO\nADSD\tB-Disease\nwas\tO\n0\tO\n.\tO\n34\tO\n%\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nBilateral\tO\nabductor\tO\nparalysis\tB-Disease\nis\tO\na\tO\nrare\tO\ncomplication\tO\nof\tO\nBotox\tB-Chemical\ninjections\tO\nfor\tO\nADSD\tB-Disease\n,\tO\ncausing\tO\ndifficulty\tO\nwith\tO\nbreathing\tO\nupon\tO\nexertion\tO\n.\tO\n\nThe\tO\nlikely\tO\nmechanism\tO\nof\tO\nparalysis\tB-Disease\nis\tO\ndiffusion\tO\nof\tO\nBotox\tB-Chemical\naround\tO\nthe\tO\nmuscular\tO\nprocess\tO\nof\tO\nthe\tO\narytenoid\tO\nto\tO\nthe\tO\nposterior\tO\ncricoarytenoid\tO\nmuscles\tO\n.\tO\n\nThe\tO\nparalysis\tB-Disease\nis\tO\ntemporary\tO\n,\tO\nand\tO\nwatchful\tO\nwaiting\tO\nwith\tO\nrestriction\tO\nof\tO\nactivity\tO\nis\tO\nthe\tO\nrecommended\tO\nmanagement\tO\n.\tO\n\nMitochondrial\tB-Disease\nimpairment\tI-Disease\ncontributes\tO\nto\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\n:\tO\nPrevention\tO\nby\tO\nthe\tO\ntargeted\tO\nantioxidant\tO\nMitoQ\tB-Chemical\n.\tO\n\nThe\tO\ngoal\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nassess\tO\nmitochondrial\tO\nfunction\tO\nand\tO\nROS\tO\nproduction\tO\nin\tO\nan\tO\nexperimental\tO\nmodel\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nWe\tO\nhypothesized\tO\nthat\tO\ncocaine\tB-Disease\nabuse\tI-Disease\nmay\tO\nlead\tO\nto\tO\naltered\tO\nmitochondrial\tO\nfunction\tO\nthat\tO\nin\tO\nturn\tO\nmay\tO\ncause\tO\nleft\tB-Disease\nventricular\tI-Disease\ndysfunction\tI-Disease\n.\tO\n\nSeven\tO\ndays\tO\nof\tO\ncocaine\tB-Chemical\nadministration\tO\nto\tO\nrats\tO\nled\tO\nto\tO\nan\tO\nincreased\tO\noxygen\tB-Chemical\nconsumption\tO\ndetected\tO\nin\tO\ncardiac\tO\nfibers\tO\n,\tO\nspecifically\tO\nthrough\tO\ncomplex\tO\nI\tO\nand\tO\ncomplex\tO\nIII\tO\n.\tO\n\nROS\tO\nlevels\tO\nwere\tO\nincreased\tO\n,\tO\nspecifically\tO\nin\tO\ninterfibrillar\tO\nmitochondria\tO\n.\tO\n\nIn\tO\nparallel\tO\nthere\tO\nwas\tO\na\tO\ndecrease\tO\nin\tO\nATP\tB-Chemical\nsynthesis\tO\n,\tO\nwhereas\tO\nno\tO\ndifference\tO\nwas\tO\nobserved\tO\nin\tO\nsubsarcolemmal\tO\nmitochondria\tO\n.\tO\n\nThis\tO\nuncoupling\tO\neffect\tO\non\tO\noxidative\tO\nphosphorylation\tO\nwas\tO\nnot\tO\ndetectable\tO\nafter\tO\nshort\tO\n-\tO\nterm\tO\nexposure\tO\nto\tO\ncocaine\tB-Chemical\n,\tO\nsuggesting\tO\nthat\tO\nthese\tO\nmitochondrial\tB-Disease\nabnormalities\tI-Disease\nwere\tO\na\tO\nlate\tO\nrather\tO\nthan\tO\na\tO\nprimary\tO\nevent\tO\nin\tO\nthe\tO\npathological\tO\nresponse\tO\nto\tO\ncocaine\tB-Chemical\n.\tO\n\nMitoQ\tB-Chemical\n,\tO\na\tO\nmitochondrial\tO\n-\tO\ntargeted\tO\nantioxidant\tO\n,\tO\nwas\tO\nshown\tO\nto\tO\ncompletely\tO\nprevent\tO\nthese\tO\nmitochondrial\tB-Disease\nabnormalities\tI-Disease\nas\tO\nwell\tO\nas\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\ncharacterized\tO\nhere\tO\nby\tO\na\tO\ndiastolic\tB-Disease\ndysfunction\tI-Disease\nstudied\tO\nwith\tO\na\tO\nconductance\tO\ncatheter\tO\nto\tO\nobtain\tO\npressure\tO\n-\tO\nvolume\tO\ndata\tO\n.\tO\n\nTaken\tO\ntogether\tO\n,\tO\nthese\tO\nresults\tO\nextend\tO\nprevious\tO\nstudies\tO\nand\tO\ndemonstrate\tO\nthat\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\nmay\tO\nbe\tO\ndue\tO\nto\tO\na\tO\nmitochondrial\tB-Disease\ndefect\tI-Disease\n.\tO\n\nTrimethoprim\tB-Chemical\n-\tO\ninduced\tO\nimmune\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nin\tO\na\tO\npediatric\tO\noncology\tO\npatient\tO\npresenting\tO\nas\tO\nan\tO\nacute\tO\nhemolytic\tO\ntransfusion\tO\nreaction\tO\n.\tO\n\nA\tO\n10\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\nwith\tO\nacute\tB-Disease\nleukemia\tI-Disease\npresented\tO\nwith\tO\npost\tO\n-\tO\nchemotherapy\tO\nanemia\tB-Disease\n.\tO\n\nDuring\tO\nred\tO\ncell\tO\ntransfusion\tO\n,\tO\nhe\tO\ndeveloped\tO\nhemoglobinuria\tB-Disease\n.\tO\n\nTransfusion\tO\nreaction\tO\nworkup\tO\nwas\tO\nnegative\tO\n.\tO\n\nDrug\tO\n-\tO\ninduced\tO\nimmune\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nwas\tO\nsuspected\tO\nbecause\tO\nof\tO\npositive\tO\ndirect\tO\nantiglobulin\tO\ntest\tO\n,\tO\nnegative\tO\neluate\tO\n,\tO\nand\tO\nmicrospherocytes\tO\non\tO\nsmear\tO\npre\tO\n-\tO\nand\tO\npost\tO\n-\tO\ntransfusion\tO\n.\tO\n\nDrug\tO\nstudies\tO\nusing\tO\nthe\tO\nindirect\tO\nantiglobulin\tO\ntest\tO\nwere\tO\nstrongly\tO\npositive\tO\nwith\tO\ntrimethoprim\tB-Chemical\nand\tO\ntrimethoprim\tB-Chemical\n-\tI-Chemical\nsulfamethoxazole\tI-Chemical\nbut\tO\nnegative\tO\nwith\tO\nsulfamethoxazole\tB-Chemical\n.\tO\n\nThe\tO\npatient\tO\nrecovered\tO\nafter\tO\ndiscontinuing\tO\nthe\tO\ndrug\tO\n,\tO\nwith\tO\nno\tO\nrecurrence\tO\nin\tO\n2\tO\nyears\tO\n.\tO\n\nOther\tO\ncauses\tO\nof\tO\nanemia\tB-Disease\nshould\tO\nbe\tO\nconsidered\tO\nin\tO\npatients\tO\nwith\tO\nworse\tO\n-\tO\nthan\tO\n-\tO\nexpected\tO\nanemia\tB-Disease\nafter\tO\nchemotherapy\tO\n.\tO\n\nFurthermore\tO\n,\tO\nhemolysis\tB-Disease\nduring\tO\ntransfusion\tO\nis\tO\nnot\tO\nalways\tO\na\tO\ntransfusion\tO\nreaction\tO\n.\tO\n\nVerapamil\tB-Chemical\nstimulation\tO\ntest\tO\nin\tO\nhyperprolactinemia\tB-Disease\n:\tO\nloss\tO\nof\tO\nprolactin\tO\nresponse\tO\nin\tO\nanatomic\tO\nor\tO\nfunctional\tO\nstalk\tO\neffect\tO\n.\tO\n\nAIM\tO\n:\tO\nVerapamil\tB-Chemical\nstimulation\tO\ntest\tO\nwas\tO\npreviously\tO\ninvestigated\tO\nas\tO\na\tO\ntool\tO\nfor\tO\ndifferential\tO\ndiagnosis\tO\nof\tO\nhyperprolactinemia\tB-Disease\n,\tO\nbut\tO\nwith\tO\nconflicting\tO\nresults\tO\n.\tO\n\nMacroprolactinemia\tB-Disease\nwas\tO\nnever\tO\nconsidered\tO\nin\tO\nthose\tO\nprevious\tO\nstudies\tO\n.\tO\n\nHere\tO\n,\tO\nwe\tO\naimed\tO\nto\tO\nre\tO\n-\tO\ninvestigate\tO\nthe\tO\ndiagnostic\tO\nvalue\tO\nof\tO\nverapamil\tB-Chemical\nin\tO\na\tO\npopulation\tO\nwho\tO\nwere\tO\nall\tO\nscreened\tO\nfor\tO\nmacroprolactinemia\tB-Disease\n.\tO\n\nProlactin\tO\nresponses\tO\nto\tO\nverapamil\tB-Chemical\nin\tO\n65\tO\nfemale\tO\npatients\tO\n(\tO\nage\tO\n:\tO\n29\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n8\tO\n.\tO\n1\tO\nyears\tO\n)\tO\nwith\tO\nhyperprolactinemia\tB-Disease\nwere\tO\ntested\tO\nin\tO\na\tO\ndescriptive\tO\n,\tO\nmatched\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nMETHODS\tO\n:\tO\nVerapamil\tB-Chemical\n80\tO\nmg\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\nwas\tO\nadministered\tO\n,\tO\nand\tO\nthen\tO\nPRL\tO\nlevels\tO\nwere\tO\nmeasured\tO\nat\tO\n8th\tO\nand\tO\n16th\tO\nhours\tO\n,\tO\nby\tO\nimmunometric\tO\nchemiluminescence\tO\n.\tO\n\nVerapamil\tB-Chemical\nresponsiveness\tO\nwas\tO\ndetermined\tO\nby\tO\npeak\tO\npercent\tO\nchange\tO\nin\tO\nbasal\tO\nprolactin\tO\nlevels\tO\n(\tO\nPRL\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nVerapamil\tB-Chemical\nsignificantly\tO\nincreased\tO\nPRL\tO\nlevels\tO\nin\tO\nhealthy\tO\ncontrols\tO\n(\tO\nN\tO\n.\tO\n8\tO\n,\tO\nPRL\tO\n:\tO\n183\tO\n%\tO\n)\tO\n,\tO\nmacroprolactinoma\tB-Disease\n(\tO\nN\tO\n.\tO\n8\tO\n,\tO\nPRL\tO\n:\tO\n7\tO\n%\tO\n)\tO\n,\tO\nmicroprolactinoma\tB-Disease\n(\tO\nN\tO\n.\tO\n19\tO\n,\tO\nPRL\tO\n:\tO\n21\tO\n%\tO\n)\tO\n,\tO\nmacroprolactinemia\tB-Disease\n(\tO\nN\tO\n.\tO\n23\tO\n,\tO\nPRL\tO\n:\tO\n126\tO\n%\tO\n)\tO\n,\tO\nbut\tO\nnot\tO\nin\tO\npseudoprolactinoma\tB-Disease\n(\tO\nN\tO\n.\tO\n8\tO\n,\tO\nPRL\tO\n:\tO\n0\tO\n.\tO\n8\tO\n%\tO\n)\tO\n,\tO\nand\tO\nrisperidone\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\n(\tO\nN\tO\n.\tO\n7\tO\n,\tO\nPRL\tO\n:\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nROC\tO\ncurve\tO\nanalysis\tO\nrevealed\tO\nthat\tO\nunresponsiveness\tO\nto\tO\nverapamil\tB-Chemical\ndefined\tO\nas\tO\nPRL\tO\n<\tO\n7\tO\n%\tO\n,\tO\ndiscriminated\tO\nanatomical\tO\nor\tO\nfunctional\tO\nstalk\tO\neffect\tO\n(\tO\nsensitivity\tO\n:\tO\n74\tO\n%\tO\n,\tO\nspecificity\tO\n:\tO\n73\tO\n%\tO\n,\tO\nAUC\tO\n:\tO\n0\tO\n.\tO\n855\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n04\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n,\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n768\tO\n-\tO\n0\tO\n.\tO\n942\tO\n)\tO\nassociated\tO\nwith\tO\npseudoprolactinoma\tB-Disease\nor\tO\nrisperidone\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\n,\tO\nrespectively\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nVerapamil\tB-Chemical\nresponsiveness\tO\nis\tO\nnot\tO\na\tO\nreliable\tO\nfinding\tO\nfor\tO\nthe\tO\ndifferential\tO\ndiagnosis\tO\nof\tO\nhyperprolactinemia\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nverapamil\tB-Chemical\nunresponsiveness\tO\ndiscriminates\tO\nstalk\tO\neffect\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nanatomically\tO\nor\tO\nfunctionally\tO\ninhibited\tO\ndopaminergic\tO\ntonus\tO\n)\tO\nfrom\tO\nother\tO\ncauses\tO\nof\tO\nhyperprolactinemia\tB-Disease\nwith\tO\nvarying\tO\ndegrees\tO\nof\tO\nresponsiveness\tO\n.\tO\n\nBlockade\tO\nof\tO\nendothelial\tO\n-\tO\nmesenchymal\tO\ntransition\tO\nby\tO\na\tO\nSmad3\tO\ninhibitor\tO\ndelays\tO\nthe\tO\nearly\tO\ndevelopment\tO\nof\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nA\tO\nmulticenter\tO\n,\tO\ncontrolled\tO\ntrial\tO\nshowed\tO\nthat\tO\nearly\tO\nblockade\tO\nof\tO\nthe\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\nin\tO\npatients\tO\nwith\tO\ntype\tB-Disease\n1\tI-Disease\ndiabetes\tI-Disease\nand\tO\nnormoalbuminuria\tO\ndid\tO\nnot\tO\nretard\tO\nthe\tO\nprogression\tO\nof\tO\nnephropathy\tB-Disease\n,\tO\nsuggesting\tO\nthat\tO\nother\tO\nmechanism\tO\n(\tO\ns\tO\n)\tO\nare\tO\ninvolved\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nearly\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n(\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n)\tO\n.\tO\n\nWe\tO\nhave\tO\npreviously\tO\ndemonstrated\tO\nthat\tO\nendothelial\tO\n-\tO\nmesenchymal\tO\n-\tO\ntransition\tO\n(\tO\nEndoMT\tO\n)\tO\ncontributes\tO\nto\tO\nthe\tO\nearly\tO\ndevelopment\tO\nof\tO\nrenal\tO\ninterstitial\tO\nfibrosis\tB-Disease\nindependently\tO\nof\tO\nmicroalbuminuria\tO\nin\tO\nmice\tO\nwith\tO\nstreptozotocin\tB-Chemical\n(\tO\nSTZ\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ndiabetes\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nwe\tO\nhypothesized\tO\nthat\tO\nblocking\tO\nEndoMT\tO\nreduces\tO\nthe\tO\nearly\tO\ndevelopment\tO\nof\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n.\tO\n\nRESEARCH\tO\nDESIGN\tO\nAND\tO\nMETHODS\tO\n:\tO\nEndoMT\tO\nwas\tO\ninduced\tO\nin\tO\na\tO\nmouse\tO\npancreatic\tO\nmicrovascular\tO\nendothelial\tO\ncell\tO\nline\tO\n(\tO\nMMEC\tO\n)\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nadvanced\tO\nglycation\tO\nend\tO\nproducts\tO\n(\tO\nAGEs\tO\n)\tO\nand\tO\nin\tO\nthe\tO\nendothelial\tO\nlineage\tO\n-\tO\ntraceble\tO\nmouse\tO\nline\tO\nTie2\tO\n-\tO\nCre\tO\n;\tO\nLoxp\tO\n-\tO\nEGFP\tO\nby\tO\nadministration\tO\nof\tO\nAGEs\tO\n,\tO\nwith\tO\nnonglycated\tO\nmouse\tO\nalbumin\tO\nserving\tO\nas\tO\na\tO\ncontrol\tO\n.\tO\n\nPhosphorylated\tO\nSmad3\tO\nwas\tO\ndetected\tO\nby\tO\nimmunoprecipitation\tO\n/\tO\nWestern\tO\nblotting\tO\nand\tO\nconfocal\tO\nmicroscopy\tO\n.\tO\n\nBlocking\tO\nstudies\tO\nusing\tO\nreceptor\tO\nfor\tO\nAGE\tO\nsiRNA\tO\nand\tO\na\tO\nspecific\tO\ninhibitor\tO\nof\tO\nSmad3\tO\n(\tO\nSIS3\tO\n)\tO\nwere\tO\nperformed\tO\nin\tO\nMMECs\tO\nand\tO\nin\tO\nSTZ\tB-Chemical\n-\tO\ninduced\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\nin\tO\nTie2\tO\n-\tO\nCre\tO\n;\tO\nLoxp\tO\n-\tO\nEGFP\tO\nmice\tO\n.\tO\n\nRESULTS\tO\n:\tO\nConfocal\tO\nmicroscopy\tO\nand\tO\nreal\tO\n-\tO\ntime\tO\nPCR\tO\ndemonstrated\tO\nthat\tO\nAGEs\tO\ninduced\tO\nEndoMT\tO\nin\tO\nMMECs\tO\nand\tO\nin\tO\nTie2\tO\n-\tO\nCre\tO\n;\tO\nLoxp\tO\n-\tO\nEGFP\tO\nmice\tO\n.\tO\n\nImmunoprecipitation\tO\n/\tO\nWestern\tO\nblotting\tO\nshowed\tO\nthat\tO\nSmad3\tO\nwas\tO\nactivated\tO\nby\tO\nAGEs\tO\nbut\tO\nwas\tO\ninhibited\tO\nby\tO\nSIS3\tO\nin\tO\nMMECs\tO\nand\tO\nin\tO\nSTZ\tB-Chemical\n-\tO\ninduced\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n.\tO\n\nConfocal\tO\nmicroscopy\tO\nand\tO\nreal\tO\n-\tO\ntime\tO\nPCR\tO\nfurther\tO\ndemonstrated\tO\nthat\tO\nSIS3\tO\nabrogated\tO\nEndoMT\tO\n,\tO\nreduced\tO\nrenal\tO\nfibrosis\tB-Disease\n,\tO\nand\tO\nretarded\tO\nprogression\tO\nof\tO\nnephropathy\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nEndoMT\tO\nis\tO\na\tO\nnovel\tO\npathway\tO\nleading\tO\nto\tO\nearly\tO\ndevelopment\tO\nof\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n.\tO\n\nBlockade\tO\nof\tO\nEndoMT\tO\nby\tO\nSIS3\tO\nmay\tO\nprovide\tO\na\tO\nnew\tO\nstrategy\tO\nto\tO\nretard\tO\nthe\tO\nprogression\tO\nof\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\nand\tO\nother\tO\ndiabetes\tB-Disease\ncomplications\tI-Disease\n.\tO\n\nCytostatic\tO\nand\tO\nanti\tO\n-\tO\nangiogenic\tO\neffects\tO\nof\tO\ntemsirolimus\tB-Chemical\nin\tO\nrefractory\tO\nmantle\tB-Disease\ncell\tI-Disease\nlymphoma\tI-Disease\n.\tO\n\nMantle\tB-Disease\ncell\tI-Disease\nlymphoma\tI-Disease\n(\tO\nMCL\tB-Disease\n)\tO\nis\tO\na\tO\nrare\tO\nand\tO\naggressive\tO\ntype\tO\nof\tO\nB\tB-Disease\n-\tI-Disease\ncell\tI-Disease\nnon\tI-Disease\n-\tI-Disease\nHodgkin\tI-Disease\n'\tI-Disease\ns\tI-Disease\nlymphoma\tI-Disease\n.\tO\n\nPatients\tO\nbecome\tO\nprogressively\tO\nrefractory\tO\nto\tO\nconventional\tO\nchemotherapy\tO\n,\tO\nand\tO\ntheir\tO\nprognosis\tO\nis\tO\npoor\tO\n.\tO\n\nHowever\tO\n,\tO\na\tO\n38\tO\n%\tO\nremission\tO\nrate\tO\nhas\tO\nbeen\tO\nrecently\tO\nreported\tO\nin\tO\nrefractory\tO\nMCL\tB-Disease\ntreated\tO\nwith\tO\ntemsirolimus\tB-Chemical\n,\tO\na\tO\nmTOR\tO\ninhibitor\tO\n.\tO\nHere\tO\nwe\tO\nhad\tO\nthe\tO\nopportunity\tO\nto\tO\nstudy\tO\na\tO\ncase\tO\nof\tO\nrefractory\tO\nMCL\tB-Disease\nwho\tO\nhad\tO\ntumor\tB-Disease\nregression\tO\ntwo\tO\nmonths\tO\nafter\tO\ntemsirolimus\tB-Chemical\ntreatment\tO\n,\tO\nand\tO\na\tO\nprogression\tO\n-\tO\nfree\tO\nsurvival\tO\nof\tO\n10\tO\nmonths\tO\n.\tO\n\nIn\tO\nthis\tO\ncase\tO\n,\tO\nlymph\tO\nnode\tO\nbiopsies\tO\nwere\tO\nperformed\tO\nbefore\tO\nand\tO\nsix\tO\nmonths\tO\nafter\tO\ntemsirolimus\tB-Chemical\ntherapy\tO\n.\tO\n\nComparison\tO\nof\tO\nthe\tO\ntwo\tO\nbiopsies\tO\nshowed\tO\nthat\tO\ntemsirolimus\tB-Chemical\ninhibited\tO\ntumor\tB-Disease\ncell\tO\nproliferation\tO\nthrough\tO\ncell\tO\ncycle\tO\narrest\tO\n,\tO\nbut\tO\ndid\tO\nnot\tO\ninduce\tO\nany\tO\nchange\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\napoptotic\tO\ntumor\tB-Disease\ncells\tO\n.\tO\n\nApart\tO\nfrom\tO\nthis\tO\ncytostatic\tO\neffect\tO\n,\tO\ntemsirolimus\tB-Chemical\nhad\tO\nan\tO\nantiangiogenic\tO\neffect\tO\nwith\tO\ndecrease\tO\nof\tO\ntumor\tB-Disease\nmicrovessel\tO\ndensity\tO\nand\tO\nof\tO\nVEGF\tO\nexpression\tO\n.\tO\n\nMoreover\tO\n,\tO\nnumerous\tO\npatchy\tO\n,\tO\nwell\tO\n-\tO\nlimited\tO\nfibrotic\tO\nareas\tO\n,\tO\ncompatible\tO\nwith\tO\npost\tO\n-\tO\nnecrotic\tB-Disease\ntissue\tO\nrepair\tO\n,\tO\nwere\tO\nfound\tO\nafter\tO\n6\tO\n-\tO\nmonth\tO\ntemsirolimus\tB-Chemical\ntherapy\tO\n.\tO\n\nThus\tO\n,\tO\ntemsirolimus\tB-Chemical\nreduced\tO\ntumor\tB-Disease\nburden\tO\nthrough\tO\nassociated\tO\ncytostatic\tO\nand\tO\nanti\tO\n-\tO\nangiogenic\tO\neffects\tO\n.\tO\nThis\tO\ndual\tO\neffect\tO\nof\tO\ntemsirolimus\tB-Chemical\non\tO\ntumor\tB-Disease\ntissue\tO\ncould\tO\ncontribute\tO\nto\tO\nits\tO\nrecently\tO\nreported\tO\nefficiency\tO\nin\tO\nrefractory\tO\nMCL\tB-Disease\nresistant\tO\nto\tO\nconventional\tO\nchemotherapy\tO\n.\tO\n\nAcute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\ndue\tO\nto\tO\nrifampicin\tB-Chemical\n.\tO\n\nA\tO\n23\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\npatient\tO\nwith\tO\nbacteriologically\tO\nproven\tO\npulmonary\tB-Disease\ntuberculosis\tI-Disease\nwas\tO\ntreated\tO\nwith\tO\nthe\tO\nvarious\tO\nregimens\tO\nof\tO\nantituberculosis\tO\ndrugs\tO\nfor\tO\nnearly\tO\n15\tO\nmonths\tO\n.\tO\n\nRifampicin\tB-Chemical\nwas\tO\nadministered\tO\nthrice\tO\nas\tO\none\tO\nof\tO\nthe\tO\n3\tO\n-\tO\n4\tO\ndrug\tO\nregimen\tO\nand\tO\neach\tO\ntime\tO\nhe\tO\ndeveloped\tO\nuntoward\tO\nside\tO\neffects\tO\nlike\tO\nnausea\tB-Disease\n,\tO\nvomiting\tB-Disease\nand\tO\nfever\tB-Disease\nwith\tO\nchills\tO\nand\tO\nrigors\tO\n.\tO\n\nThe\tO\nlast\tO\nsuch\tO\nepisode\tO\nwas\tO\nof\tO\nacute\tO\nrenal\tO\nfailure\tO\nat\tO\nwhich\tO\nstage\tO\nthe\tO\npatient\tO\nwas\tO\nseen\tO\nby\tO\nthe\tO\nauthors\tO\nof\tO\nthis\tO\nreport\tO\n.\tO\n\nThe\tO\npatient\tO\n,\tO\nhowever\tO\n,\tO\nmade\tO\na\tO\nfull\tO\nrecovery\tO\n.\tO\n\nSyncope\tB-Disease\ncaused\tO\nby\tO\nhyperkalemia\tB-Disease\nduring\tO\nuse\tO\nof\tO\na\tO\ncombined\tO\ntherapy\tO\nwith\tO\nthe\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\nand\tO\nspironolactone\tB-Chemical\n.\tO\n\nA\tO\n76\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\ncoronary\tO\nartery\tO\nbypass\tO\ngrafting\tO\nand\tO\nprior\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\ntransferred\tO\nto\tO\nthe\tO\nemergency\tO\nroom\tO\nwith\tO\nloss\tB-Disease\nof\tI-Disease\nconsciousness\tI-Disease\ndue\tO\nto\tO\nmarked\tO\nbradycardia\tB-Disease\ncaused\tO\nby\tO\nhyperkalemia\tB-Disease\n.\tO\n\nThe\tO\nconcentration\tO\nof\tO\nserum\tO\npotassium\tB-Chemical\nwas\tO\nhigh\tO\n,\tO\nand\tO\nnormal\tO\nsinus\tO\nrhythm\tO\nwas\tO\nrestored\tO\nafter\tO\ncorrection\tO\nof\tO\nthe\tO\nserum\tO\npotassium\tB-Chemical\nlevel\tO\n.\tO\n\nThe\tO\ncause\tO\nof\tO\nhyperkalemia\tB-Disease\nwas\tO\nconsidered\tO\nto\tO\nbe\tO\nseveral\tO\ndoses\tO\nof\tO\nspiranolactone\tB-Chemical\n,\tO\nan\tO\naldosterone\tB-Chemical\nantagonist\tO\n,\tO\nin\tO\naddition\tO\nto\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nintake\tO\nof\tO\nramipril\tB-Chemical\n,\tO\nan\tO\nACE\tO\ninhibitor\tO\n.\tO\n\nThis\tO\ncase\tO\nis\tO\na\tO\ngood\tO\nexample\tO\nof\tO\nelectrolyte\tO\nimbalance\tO\ncausing\tO\nacute\tO\nlife\tO\n-\tO\nthreatening\tO\ncardiac\tO\nevents\tO\n.\tO\n\nClinicians\tO\nshould\tO\nbe\tO\nalert\tO\nto\tO\nthe\tO\npossibility\tO\nof\tO\nhyperkalemia\tB-Disease\n,\tO\nespecially\tO\nin\tO\nelderly\tO\npatients\tO\nusing\tO\nACE\tO\n/\tO\nARB\tO\nin\tO\ncombination\tO\nwith\tO\npotassium\tB-Chemical\nsparing\tO\nagents\tO\nand\tO\nwho\tO\nhave\tO\nmild\tO\nrenal\tB-Disease\ndisturbance\tI-Disease\n.\tO\n\nDiffuse\tO\nskeletal\tO\npain\tB-Disease\nafter\tO\nadministration\tO\nof\tO\nalendronate\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nOsteoporosis\tB-Disease\nis\tO\ncaused\tO\nby\tO\nbone\tO\nresorption\tO\nin\tO\nexcess\tO\nof\tO\nbone\tO\nformation\tO\n,\tO\nand\tO\nbisphosphonates\tB-Chemical\n,\tO\nare\tO\nused\tO\nto\tO\ninhibit\tO\nbone\tO\nresorption\tO\n.\tO\n\nAlendronate\tB-Chemical\n,\tO\na\tO\nbiphosphonate\tB-Chemical\n,\tO\nis\tO\neffective\tO\nfor\tO\nboth\tO\nthe\tO\ntreatment\tO\nand\tO\nprevention\tO\nof\tO\nosteoporosis\tB-Disease\nin\tO\npostmenopausal\tO\nwomen\tO\n.\tO\n\nSide\tO\neffects\tO\nare\tO\nrelatively\tO\nfew\tO\nand\tO\nprominently\tO\ngastrointestinal\tO\n.\tO\n\nMusculoskeletal\tB-Disease\npain\tI-Disease\nmay\tO\nbe\tO\nan\tO\nimportant\tO\nside\tO\neffect\tO\nin\tO\nthese\tO\npatients\tO\n.\tO\n\nWe\tO\npresented\tO\na\tO\npatient\tO\nadmitted\tO\nto\tO\nour\tO\nout\tO\n-\tO\npatient\tO\nclinic\tO\nwith\tO\ndiffuse\tO\nskeletal\tO\npain\tB-Disease\nafter\tO\nthree\tO\nconsecutive\tO\nadministration\tO\nof\tO\nalendronate\tB-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nWe\tO\nconclude\tO\nthat\tO\npatients\tO\nwith\tO\nosteoporosis\tB-Disease\ncan\tO\nreport\tO\npain\tB-Disease\n,\tO\nand\tO\nbisphosphonate\tB-Chemical\n-\tO\nrelated\tO\npain\tB-Disease\nshould\tO\nalso\tO\nbe\tO\nconsidered\tO\nbefore\tO\nascribing\tO\nthis\tO\ncomplaint\tO\nto\tO\nosteoporosis\tB-Disease\n.\tO\n\nCerebrospinal\tO\nfluid\tO\npenetration\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\ndaptomycin\tB-Chemical\nin\tO\nsuspected\tO\nStaphylococcus\tO\naureus\tO\nmeningitis\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nmethicillin\tB-Chemical\n-\tO\nsensitive\tO\nStaphylococcus\tO\naureus\tO\n(\tO\nMSSA\tO\n)\tO\nbacteremia\tB-Disease\nwith\tO\nsuspected\tO\nMSSA\tO\nmeningitis\tB-Disease\ntreated\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\ndaptomycin\tB-Chemical\nassessed\tO\nwith\tO\nconcurrent\tO\nserum\tO\nand\tO\ncerebrospinal\tO\nfluid\tO\n(\tO\nCSF\tO\n)\tO\nconcentrations\tO\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n54\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\npresented\tO\nto\tO\nthe\tO\nemergency\tO\ndepartment\tO\nwith\tO\ngeneralized\tO\nweakness\tB-Disease\nand\tO\npresumed\tO\nhealth\tO\n-\tO\ncare\tO\n-\tO\nassociated\tO\npneumonia\tB-Disease\nshown\tO\non\tO\nchest\tO\nradiograph\tO\n.\tO\n\nTreatment\tO\nwas\tO\nempirically\tO\ninitiated\tO\nwith\tO\nvancomycin\tB-Chemical\n,\tO\nlevofloxacin\tB-Chemical\n,\tO\nand\tO\npiperacillin\tB-Chemical\n/\tO\ntazobactam\tB-Chemical\n.\tO\n\nBlood\tO\ncultures\tO\nrevealed\tO\nS\tO\n.\tO\naureus\tO\nsusceptible\tO\nto\tO\noxacillin\tB-Chemical\n.\tO\n\nEmpiric\tO\nantibiotic\tO\ntreatment\tO\nwas\tO\nnarrowed\tO\nto\tO\nnafcillin\tB-Chemical\non\tO\nday\tO\n4\tO\n.\tO\n\nOn\tO\nday\tO\n8\tO\n,\tO\nthe\tO\npatient\tO\ndeveloped\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n(\tO\nserum\tO\ncreatinine\tB-Chemical\n1\tO\n.\tO\n9\tO\nmg\tO\n/\tO\ndL\tO\n,\tO\nincreased\tO\nfrom\tO\n1\tO\n.\tO\n2\tO\nmg\tO\n/\tO\ndL\tO\nthe\tO\nprevious\tO\nday\tO\nand\tO\n0\tO\n.\tO\n8\tO\nmg\tO\n/\tO\ndL\tO\non\tO\nadmission\tO\n)\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nGlasgow\tO\nComa\tO\nScore\tO\nwas\tO\n3\tO\n,\tO\nwith\tO\nnormal\tO\nfindings\tO\nshown\tO\non\tO\ncomputed\tO\ntomography\tO\nscan\tO\nof\tO\nthe\tO\nhead\tO\n72\tO\nhours\tO\nfollowing\tO\nan\tO\nepisode\tO\nof\tO\ncardiac\tB-Disease\narrest\tI-Disease\non\tO\nday\tO\n10\tO\n.\tO\n\nThe\tO\npatient\tO\nexperienced\tO\nrelapsing\tO\nMSSA\tO\nbacteremia\tB-Disease\non\tO\nday\tO\n9\tO\n,\tO\nincreasing\tO\nthe\tO\nsuspicion\tO\nfor\tO\na\tO\ncentral\tO\nnervous\tO\nsystem\tO\n(\tO\nCNS\tO\n)\tO\ninfection\tB-Disease\n.\tO\n\nNafcillin\tB-Chemical\nwas\tO\ndiscontinued\tO\nand\tO\ndaptomycin\tB-Chemical\n9\tO\nmg\tO\n/\tO\nkg\tO\ndaily\tO\nwas\tO\ninitiated\tO\nfor\tO\nsuspected\tO\nmeningitis\tB-Disease\nand\tO\nwas\tO\ncontinued\tO\nuntil\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\ndeath\tO\non\tO\nday\tO\n16\tO\n.\tO\n\nDaptomycin\tB-Chemical\nserum\tO\nand\tO\nCSF\tO\ntrough\tO\nconcentrations\tO\nwere\tO\n11\tO\n.\tO\n21\tO\nug\tO\n/\tO\nmL\tO\nand\tO\n0\tO\n.\tO\n52\tO\nug\tO\n/\tO\nmL\tO\n,\tO\nrespectively\tO\n,\tO\nprior\tO\nto\tO\nthe\tO\nthird\tO\ndose\tO\n.\tO\n\nLumbar\tO\npuncture\tO\nresults\tO\nwere\tO\ninconclusive\tO\nand\tO\nno\tO\nfurther\tO\nblood\tO\ncultures\tO\nwere\tO\npositive\tO\nfor\tO\nMSSA\tO\n.\tO\n\nCreatine\tB-Chemical\nkinase\tO\nlevels\tO\nwere\tO\nnormal\tO\nprior\tO\nto\tO\ndaptomycin\tB-Chemical\ntherapy\tO\nand\tO\nwere\tO\nnot\tO\nreassessed\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nDaptomycin\tB-Chemical\nwas\tO\ninitiated\tO\nin\tO\nour\tO\npatient\tO\nsecondary\tO\nto\tO\npossible\tO\nnafcillin\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nand\tO\nrelapsing\tO\nbacteremia\tB-Disease\n.\tO\n\nAt\tO\na\tO\ndose\tO\nof\tO\n9\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nresultant\tO\npenetration\tO\nof\tO\n5\tO\n%\tO\nwas\tO\nhigher\tO\nthan\tO\nin\tO\nprevious\tO\nreports\tO\n,\tO\nmore\tO\nconsistent\tO\nwith\tO\ninflamed\tO\nmeninges\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nHigh\tO\n-\tO\ndose\tO\ndaptomycin\tB-Chemical\nmay\tO\nbe\tO\nan\tO\nalternative\tO\noption\tO\nfor\tO\nMSSA\tO\nbacteremia\tB-Disease\nwith\tO\nor\tO\nwithout\tO\na\tO\nCNS\tO\nsource\tO\nin\tO\npatients\tO\nwho\tO\nhave\tO\nfailed\tO\nor\tO\ncannot\tO\ntolerate\tO\nstandard\tO\ntherapy\tO\n.\tO\n\nFurther\tO\nclinical\tO\nevaluation\tO\nin\tO\npatients\tO\nwith\tO\nconfirmed\tO\nmeningitis\tB-Disease\nis\tO\nwarranted\tO\n.\tO\n\nThe\tO\nrole\tO\nof\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nin\tO\nconvulsions\tB-Disease\ninduced\tO\nby\tO\nlindane\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nLindane\tB-Chemical\nis\tO\nan\tO\norganochloride\tO\npesticide\tO\nand\tO\nscabicide\tO\n.\tO\n\nIt\tO\nevokes\tO\nconvulsions\tB-Disease\nmainly\tO\ntrough\tO\nthe\tO\nblockage\tO\nof\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptors\tO\n.\tO\n\nNitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\n,\tO\ngaseous\tO\nneurotransmitter\tO\n,\tO\nhas\tO\ncontradictor\tO\nrole\tO\nin\tO\nepileptogenesis\tO\ndue\tO\nto\tO\nopposite\tO\neffects\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n,\tO\nprecursor\tO\nof\tO\nNO\tB-Chemical\nsyntheses\tO\n(\tO\nNOS\tO\n)\tO\n,\tO\nand\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n(\tO\nNOS\tO\ninhibitor\tO\n)\tO\nobserved\tO\nin\tO\ndifferent\tO\nepilepsy\tB-Disease\nmodels\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\ncurrent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\neffects\tO\nof\tO\nNO\tB-Chemical\non\tO\nthe\tO\nbehavioral\tO\nand\tO\nEEG\tO\ncharacteristics\tO\nof\tO\nlindane\tB-Chemical\n-\tO\ninduced\tO\nepilepsy\tB-Disease\nin\tO\nmale\tO\nWistar\tO\nalbino\tO\nrats\tO\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n(\tO\n600\tO\n,\tO\n800\tO\nand\tO\n1000\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nin\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\nsignificantly\tO\nincreased\tO\nconvulsion\tB-Disease\nincidence\tO\nand\tO\nseverity\tO\nand\tO\nshortened\tO\nlatency\tO\ntime\tO\nto\tO\nfirst\tO\nconvulsion\tB-Disease\nelicited\tO\nby\tO\nlower\tO\nlindane\tB-Chemical\ndose\tO\n(\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nOn\tO\nthe\tO\ncontrary\tO\n,\tO\npretreatment\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n(\tO\n500\tO\n,\tO\n700\tO\nand\tO\n900\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\ndecreased\tO\nconvulsion\tB-Disease\nincidence\tO\nand\tO\nseverity\tO\nand\tO\nprolonged\tO\nlatency\tO\ntime\tO\nto\tO\nconvulsion\tB-Disease\nfollowing\tO\ninjection\tO\nwith\tO\na\tO\nconvulsive\tB-Disease\ndose\tO\nof\tO\nlindane\tB-Chemical\n(\tO\n8\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nEEG\tO\nanalyses\tO\nshowed\tO\nincrease\tO\nof\tO\nnumber\tO\nand\tO\nduration\tO\nof\tO\nictal\tO\nperiods\tO\nin\tO\nEEG\tO\nof\tO\nrats\tO\nreceiving\tO\nl\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nprior\tO\nto\tO\nlindane\tB-Chemical\nand\tO\ndecrease\tO\nof\tO\nthis\tO\nnumber\tO\nin\tO\nrats\tO\npretreated\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n.\tO\n\nThese\tO\nresults\tO\nsupport\tO\nthe\tO\nconclusion\tO\nthat\tO\nNO\tB-Chemical\nplays\tO\na\tO\nrole\tO\nof\tO\nendogenous\tO\nconvulsant\tO\nin\tO\nrat\tO\nmodel\tO\nof\tO\nlindane\tB-Chemical\nseizures\tB-Disease\n.\tO\n\nSevere\tO\npolyneuropathy\tB-Disease\nand\tO\nmotor\tO\nloss\tO\nafter\tO\nintrathecal\tO\nthiotepa\tB-Chemical\ncombination\tO\nchemotherapy\tO\n:\tO\ndescription\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nTwo\tO\ncases\tO\nof\tO\nsevere\tO\ndelayed\tO\nneurologic\tB-Disease\ntoxicity\tI-Disease\nrelated\tO\nto\tO\nthe\tO\nadministration\tO\nof\tO\nintrathecal\tO\n(\tO\nIT\tO\n)\tO\ncombination\tO\nchemotherapy\tO\nincluding\tO\nthiotepa\tB-Chemical\n(\tO\nTSPA\tB-Chemical\n)\tO\nare\tO\npresented\tO\n.\tO\n\nBoth\tO\ncases\tO\ndeveloped\tO\naxonal\tB-Disease\nneuropathy\tI-Disease\nwith\tO\nmotor\tO\npredominance\tO\nin\tO\nthe\tO\nlower\tO\nextremities\tO\n1\tO\nand\tO\n6\tO\nmonths\tO\nafter\tO\nIT\tO\nchemotherapy\tO\nwas\tO\nadministered\tO\n.\tO\n\nNeurologic\tB-Disease\ntoxicities\tI-Disease\nhave\tO\nbeen\tO\ndescribed\tO\nwith\tO\nIT\tO\n-\tO\nmethotrexate\tB-Chemical\n,\tO\nIT\tO\n-\tO\ncytosine\tB-Chemical\narabinoside\tI-Chemical\nand\tO\nIT\tO\n-\tO\nTSPA\tB-Chemical\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nhowever\tO\n,\tO\naxonal\tB-Disease\nneuropathy\tI-Disease\nfollowing\tO\nadministration\tO\nof\tO\nthese\tO\nthree\tO\nagents\tO\nhas\tO\nnot\tO\nbeen\tO\npreviously\tO\ndescribed\tO\n.\tO\n\nIn\tO\nspite\tO\nof\tO\nthe\tO\nfact\tO\nthat\tO\nTSPA\tB-Chemical\nis\tO\na\tO\nuseful\tO\nIT\tO\nagent\tO\n,\tO\nits\tO\ncombination\tO\nwith\tO\nMTX\tB-Chemical\n,\tO\nara\tB-Chemical\n-\tI-Chemical\nC\tI-Chemical\nand\tO\nradiotherapy\tO\ncould\tO\ncause\tO\nsevere\tO\nneurotoxicity\tB-Disease\n.\tO\n\nThis\tO\nunexpected\tO\ncomplication\tO\nindicates\tO\nthe\tO\nneed\tO\nfor\tO\nfurther\tO\ntoxicology\tO\nresearch\tO\non\tO\nIT\tO\n-\tO\nTSPA\tB-Chemical\n.\tO\n\nEffects\tO\nof\tO\ncromakalim\tB-Chemical\nand\tO\npinacidil\tB-Chemical\non\tO\nlarge\tO\nepicardial\tO\nand\tO\nsmall\tO\ncoronary\tO\narteries\tO\nin\tO\nconscious\tO\ndogs\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ni\tO\n.\tO\nv\tO\n.\tO\nbolus\tO\nadministration\tO\nof\tO\ncromakalim\tB-Chemical\n(\tO\n1\tO\n-\tO\n10\tO\nmicrograms\tO\n/\tO\nkg\tO\n)\tO\nand\tO\npinacidil\tB-Chemical\n(\tO\n3\tO\n-\tO\n100\tO\nmicrograms\tO\n/\tO\nkg\tO\n)\tO\non\tO\nlarge\tO\n(\tO\ncircumflex\tO\nartery\tO\n)\tO\nand\tO\nsmall\tO\ncoronary\tO\narteries\tO\nand\tO\non\tO\nsystemic\tO\nhemodynamics\tO\nwere\tO\ninvestigated\tO\nin\tO\nchronically\tO\ninstrumented\tO\nconscious\tO\ndogs\tO\nand\tO\ncompared\tO\nto\tO\nthose\tO\nof\tO\nnitroglycerin\tB-Chemical\n(\tO\n0\tO\n.\tO\n03\tO\n-\tO\n10\tO\nmicrograms\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nNitroglycerin\tB-Chemical\n,\tO\nup\tO\nto\tO\n0\tO\n.\tO\n3\tO\nmicrograms\tO\n/\tO\nkg\tO\n,\tO\nselectively\tO\nincreased\tO\ncircumflex\tO\nartery\tO\ndiameter\tO\n(\tO\nCxAD\tO\n)\tO\nwithout\tO\nsimultaneously\tO\naffecting\tO\nany\tO\nother\tO\ncardiac\tO\nor\tO\nsystemic\tO\nhemodynamic\tO\nparameter\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\ncromakalim\tB-Chemical\nand\tO\npinacidil\tB-Chemical\nat\tO\nall\tO\ndoses\tO\nand\tO\nnitroglycerin\tB-Chemical\nat\tO\ndoses\tO\nhigher\tO\nthan\tO\n0\tO\n.\tO\n3\tO\nmicrograms\tO\n/\tO\nkg\tO\nsimultaneously\tO\nand\tO\ndose\tO\n-\tO\ndependently\tO\nincreased\tO\nCxAD\tO\n,\tO\ncoronary\tO\nblood\tO\nflow\tO\nand\tO\nheart\tO\nrate\tO\nand\tO\ndecreased\tO\ncoronary\tO\nvascular\tO\nresistance\tO\nand\tO\naortic\tO\npressure\tO\n.\tO\n\nCromakalim\tB-Chemical\nwas\tO\napproximately\tO\n8\tO\n-\tO\nto\tO\n9\tO\n.\tO\n5\tO\n-\tO\nfold\tO\nmore\tO\npotent\tO\nthan\tO\npinacidil\tB-Chemical\nin\tO\nincreasing\tO\nCxAD\tO\n.\tO\n\nVasodilation\tO\nof\tO\nlarge\tO\nand\tO\nsmall\tO\ncoronary\tO\nvessels\tO\nand\tO\nhypotension\tB-Disease\ninduced\tO\nby\tO\ncromakalim\tB-Chemical\nand\tO\npinacidil\tB-Chemical\nwere\tO\nnot\tO\naffected\tO\nby\tO\nprior\tO\ncombined\tO\nbeta\tB-Chemical\nadrenergic\tI-Chemical\nand\tI-Chemical\nmuscarinic\tI-Chemical\nreceptors\tI-Chemical\nblockade\tI-Chemical\nbut\tO\ndrug\tO\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nwas\tO\nabolished\tO\n.\tO\n\nWhen\tO\ncircumflex\tO\nartery\tO\nblood\tO\nflow\tO\nwas\tO\nmaintained\tO\nconstant\tO\n,\tO\nthe\tO\nincreases\tO\nin\tO\nCxAD\tO\ninduced\tO\nby\tO\ncromakalim\tB-Chemical\n(\tO\n10\tO\nmicrograms\tO\n/\tO\nkg\tO\n)\tO\n,\tO\npinacidil\tB-Chemical\n(\tO\n30\tO\nmicrograms\tO\n/\tO\nkg\tO\n)\tO\nand\tO\nnitroglycerin\tB-Chemical\n(\tO\n10\tO\nmicrograms\tO\n/\tO\nkg\tO\n)\tO\nwere\tO\nreduced\tO\nby\tO\n68\tO\n+\tO\n/\tO\n-\tO\n7\tO\n,\tO\n54\tO\n+\tO\n/\tO\n-\tO\n9\tO\nand\tO\n1\tO\n+\tO\n/\tO\n-\tO\n1\tO\n%\tO\n,\tO\nrespectively\tO\n.\tO\n\nThus\tO\n,\tO\nwhereas\tO\nnitroglycerin\tB-Chemical\npreferentially\tO\nand\tO\nflow\tO\n-\tO\nindependently\tO\ndilates\tO\nlarge\tO\ncoronary\tO\narteries\tO\n,\tO\ncromakalim\tB-Chemical\nand\tO\npinacidil\tB-Chemical\ndilate\tO\nboth\tO\nlarge\tO\nand\tO\nsmall\tO\ncoronary\tO\narteries\tO\nand\tO\nthis\tO\neffect\tO\nis\tO\nnot\tO\ndependent\tO\nupon\tO\nthe\tO\nsimultaneous\tO\nbeta\tO\nadrenoceptors\tO\n-\tO\nmediated\tO\nrise\tO\nin\tO\nmyocardial\tO\nmetabolic\tO\ndemand\tO\n.\tO\n\nFinally\tO\n,\tO\ntwo\tO\nmechanisms\tO\nat\tO\nleast\tO\n,\tO\ndirect\tO\nvasodilation\tO\nand\tO\nflow\tO\ndependency\tO\n,\tO\nare\tO\ninvolved\tO\nin\tO\nthe\tO\ncromakalim\tB-Chemical\n-\tO\nand\tO\npinacidil\tB-Chemical\n-\tO\ninduced\tO\nincrease\tO\nin\tO\nCxAD\tO\n.\tO\n\nMefenamic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nneutropenia\tB-Disease\nand\tO\nrenal\tB-Disease\nfailure\tI-Disease\nin\tO\nelderly\tO\nfemales\tO\nwith\tO\nhypothyroidism\tB-Disease\n.\tO\n\nWe\tO\nreport\tO\nmefenamic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nnon\tO\n-\tO\noliguric\tO\nrenal\tB-Disease\nfailure\tI-Disease\nand\tO\nsevere\tO\nneutropenia\tB-Disease\noccurring\tO\nsimultaneously\tO\nin\tO\ntwo\tO\nelderly\tO\nfemales\tO\n.\tO\n\nThe\tO\nneutropenia\tB-Disease\nwas\tO\ndue\tO\nto\tO\nmaturation\tO\narrest\tO\nof\tO\nthe\tO\nmyeloid\tO\nseries\tO\nin\tO\none\tO\npatient\tO\n.\tO\n\nBoth\tO\npatients\tO\nwere\tO\nalso\tO\nhypothyroid\tB-Disease\n,\tO\nbut\tO\nit\tO\nis\tO\nnot\tO\nclear\tO\nwhether\tO\nthis\tO\nwas\tO\na\tO\npredisposing\tO\nfactor\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\nthese\tO\nadverse\tO\nreactions\tO\n.\tO\n\nHowever\tO\n,\tO\nit\tO\nwould\tO\nseem\tO\nprudent\tO\nnot\tO\nto\tO\nuse\tO\nmefenamic\tB-Chemical\nacid\tI-Chemical\nin\tO\nhypothyroid\tB-Disease\npatients\tO\nuntil\tO\nthe\tO\nhypothyroidism\tB-Disease\nhas\tO\nbeen\tO\ncorrected\tO\n.\tO\n\nEtiology\tO\nof\tO\nhypercalcemia\tB-Disease\nin\tO\nhemodialysis\tO\npatients\tO\non\tO\ncalcium\tB-Chemical\ncarbonate\tI-Chemical\ntherapy\tO\n.\tO\n\nFourteen\tO\nof\tO\n39\tO\ndialysis\tO\npatients\tO\n(\tO\n36\tO\n%\tO\n)\tO\nbecame\tO\nhypercalcemic\tB-Disease\nafter\tO\nswitching\tO\nto\tO\ncalcium\tB-Chemical\ncarbonate\tI-Chemical\nas\tO\ntheir\tO\nprincipal\tO\nphosphate\tB-Chemical\nbinder\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\nidentify\tO\nrisk\tO\nfactors\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nhypercalcemia\tB-Disease\n,\tO\nindirect\tO\nparameters\tO\nof\tO\nintestinal\tO\ncalcium\tB-Chemical\nreabsorption\tO\nand\tO\nbone\tO\nturnover\tO\nrate\tO\nin\tO\nthese\tO\n14\tO\npatients\tO\nwere\tO\ncompared\tO\nwith\tO\nresults\tO\nin\tO\n14\tO\neucalcemic\tO\npatients\tO\nmatched\tO\nfor\tO\nage\tO\n,\tO\nsex\tO\n,\tO\nlength\tO\nof\tO\ntime\tO\non\tO\ndialysis\tO\n,\tO\nand\tO\netiology\tO\nof\tO\nrenal\tB-Disease\ndisease\tI-Disease\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nexperiencing\tO\nhypercalcemic\tB-Disease\nepisodes\tO\nwith\tO\npeak\tO\ncalcium\tB-Chemical\nvalues\tO\nof\tO\n2\tO\n.\tO\n7\tO\nto\tO\n3\tO\n.\tO\n8\tO\nmmol\tO\n/\tO\nL\tO\n(\tO\n10\tO\n.\tO\n7\tO\nto\tO\n15\tO\n.\tO\n0\tO\nmg\tO\n/\tO\ndL\tO\n)\tO\n,\tO\npatients\tO\nin\tO\nthe\tO\nhypercalcemic\tB-Disease\ngroup\tO\nexhibited\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nthe\tO\nmean\tO\ncalcium\tB-Chemical\nconcentration\tO\nobtained\tO\nduring\tO\n6\tO\nmonths\tO\nbefore\tO\nthe\tO\nswitch\tO\n,\tO\ncompared\tO\nwith\tO\nthe\tO\nmean\tO\nvalue\tO\nobtained\tO\nduring\tO\nthe\tO\n7\tO\nmonths\tO\nof\tO\nobservation\tO\nafter\tO\nthe\tO\nswitch\tO\n(\tO\n2\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n03\tO\nto\tO\n2\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n03\tO\nmmol\tO\n/\tO\nL\tO\n[\tO\n9\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nto\tO\n10\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nmg\tO\n/\tO\ndL\tO\n]\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n006\tO\n)\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\neucalcemic\tO\npatients\tO\nexhibited\tO\nno\tO\nchange\tO\nin\tO\nmean\tO\ncalcium\tB-Chemical\nvalues\tO\nover\tO\nthe\tO\nsame\tO\ntime\tO\nperiod\tO\n(\tO\n2\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n05\tO\nto\tO\n2\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n05\tO\nmmol\tO\n/\tO\nL\tO\n[\tO\n9\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nto\tO\n9\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nmg\tO\n/\tO\ndL\tO\n]\tO\n)\tO\n.\tO\n\nCaCO3\tB-Chemical\ndosage\tO\n,\tO\ncalculated\tO\ndietary\tO\ncalcium\tB-Chemical\nintake\tO\n,\tO\nand\tO\ncirculating\tO\nlevels\tO\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nmetabolites\tO\nwere\tO\nsimilar\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nPhysical\tO\nactivity\tO\nindex\tO\nand\tO\npredialysis\tO\nserum\tO\nbicarbonate\tB-Chemical\nlevels\tO\nalso\tO\nwere\tO\nsimilar\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nsignificant\tO\ndifference\tO\nin\tO\nparameters\tO\nreflecting\tO\nbone\tO\nturnover\tO\nrates\tO\nbetween\tO\ngroups\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nLate\tO\n-\tO\nonset\tO\nscleroderma\tB-Disease\nrenal\tI-Disease\ncrisis\tI-Disease\ninduced\tO\nby\tO\ntacrolimus\tB-Chemical\nand\tO\nprednisolone\tB-Chemical\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nScleroderma\tB-Disease\nrenal\tI-Disease\ncrisis\tI-Disease\n(\tO\nSRC\tB-Disease\n)\tO\nis\tO\na\tO\nrare\tO\ncomplication\tO\nof\tO\nsystemic\tB-Disease\nsclerosis\tI-Disease\n(\tO\nSSc\tB-Disease\n)\tO\nbut\tO\ncan\tO\nbe\tO\nsevere\tO\nenough\tO\nto\tO\nrequire\tO\ntemporary\tO\nor\tO\npermanent\tO\nrenal\tO\nreplacement\tO\ntherapy\tO\n.\tO\n\nModerate\tO\nto\tO\nhigh\tO\ndose\tO\ncorticosteroid\tB-Chemical\nuse\tO\nis\tO\nrecognized\tO\nas\tO\na\tO\nmajor\tO\nrisk\tO\nfactor\tO\nfor\tO\nSRC\tB-Disease\n.\tO\n\nFurthermore\tO\n,\tO\nthere\tO\nhave\tO\nbeen\tO\nreports\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nprecipitated\tO\nby\tO\ncyclosporine\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nSSc\tB-Disease\n.\tO\n\nIn\tO\nthis\tO\narticle\tO\n,\tO\nwe\tO\nreport\tO\na\tO\npatient\tO\nwith\tO\nSRC\tB-Disease\ninduced\tO\nby\tO\ntacrolimus\tB-Chemical\nand\tO\ncorticosteroids\tB-Chemical\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nwork\tO\nis\tO\nto\tO\ncall\tO\nattention\tO\nto\tO\nthe\tO\nrisk\tO\nof\tO\ntacrolimus\tB-Chemical\nuse\tO\nin\tO\npatients\tO\nwith\tO\nSSc\tB-Disease\n.\tO\n\nMethyldopa\tB-Chemical\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nin\tO\na\tO\n15\tO\nyear\tO\nold\tO\npresenting\tO\nas\tO\nnear\tO\n-\tO\nsyncope\tB-Disease\n.\tO\n\nMethyldopa\tB-Chemical\nis\tO\nan\tO\nantihypertensive\tO\nmedication\tO\nwhich\tO\nis\tO\navailable\tO\ngenerically\tO\nand\tO\nunder\tO\nthe\tO\ntrade\tO\nname\tO\nAldomet\tB-Chemical\nthat\tO\nis\tO\nwidely\tO\nprescribed\tO\nin\tO\nthe\tO\nadult\tO\npopulation\tO\nand\tO\ninfrequently\tO\nused\tO\nin\tO\nchildren\tO\n.\tO\n\nMethyldopa\tB-Chemical\ncauses\tO\nan\tO\nautoimmune\tB-Disease\nhemolytic\tI-Disease\nanemia\tI-Disease\nin\tO\na\tO\nsmall\tO\npercentage\tO\nof\tO\npatients\tO\nwho\tO\ntake\tO\nthe\tO\ndrug\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nmethyldopa\tB-Chemical\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nin\tO\na\tO\n15\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwho\tO\npresented\tO\nto\tO\nthe\tO\nemergency\tB-Disease\ndepartment\tI-Disease\nwith\tO\nnear\tO\n-\tO\nsyncope\tB-Disease\n.\tO\n\nThe\tO\nboy\tO\nhad\tO\nbeen\tO\ntreated\tO\nwith\tO\nintravenous\tO\nmethyldopa\tB-Chemical\nduring\tO\na\tO\ntrauma\tB-Disease\nadmission\tO\nseven\tO\nweeks\tO\nprior\tO\nto\tO\npresentation\tO\n.\tO\n\nEvaluation\tO\nrevealed\tO\na\tO\nhemoglobin\tO\nof\tO\nthree\tO\ngrams\tO\n,\tO\n3\tO\n+\tO\nCoombs\tO\n'\tO\ntest\tO\nwith\tO\npolyspecific\tO\nanti\tO\n-\tO\nhuman\tO\nglobulin\tO\nand\tO\nmonospecific\tO\nIgG\tO\nreagents\tO\n,\tO\nand\tO\na\tO\nwarm\tO\nreacting\tO\nautoantibody\tO\n.\tO\n\nTransfusion\tO\nand\tO\ncorticosteroid\tB-Chemical\ntherapy\tO\nresulted\tO\nin\tO\na\tO\ncomplete\tO\nrecovery\tO\nof\tO\nthe\tO\npatient\tO\n.\tO\n\nEmergency\tO\nphysicians\tO\ntreating\tO\nchildren\tO\nmust\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\nsyndrome\tO\nin\tO\norder\tO\nto\tO\ndiagnose\tO\nand\tO\ntreat\tO\nit\tO\ncorrectly\tO\n.\tO\n\nA\tO\nbrief\tO\nreview\tO\nof\tO\nautoimmune\tO\nand\tO\ndrug\tO\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemias\tI-Disease\nis\tO\nprovided\tO\n.\tO\n\nThe\tO\nrisk\tO\nand\tO\nassociated\tO\nfactors\tO\nof\tO\nmethamphetamine\tB-Chemical\npsychosis\tB-Disease\nin\tO\nmethamphetamine\tB-Chemical\n-\tO\ndependent\tO\npatients\tO\nin\tO\nMalaysia\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\nrisk\tO\nof\tO\nlifetime\tO\nand\tO\ncurrent\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\nin\tO\npatients\tO\nwith\tO\nmethamphetamine\tB-Chemical\ndependence\tO\n.\tO\n\nThe\tO\nassociation\tO\nbetween\tO\npsychiatric\tO\nco\tO\n-\tO\nmorbidity\tO\nand\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\nwas\tO\nalso\tO\nstudied\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nwas\tO\na\tO\ncross\tO\n-\tO\nsectional\tO\nstudy\tO\nconducted\tO\nconcurrently\tO\nat\tO\na\tO\nteaching\tO\nhospital\tO\nand\tO\na\tO\ndrug\tO\nrehabilitation\tO\ncenter\tO\nin\tO\nMalaysia\tO\n.\tO\n\nPatients\tO\nwith\tO\nthe\tO\ndiagnosis\tO\nof\tO\nmethamphetamine\tB-Chemical\nbased\tO\non\tO\nDSM\tO\n-\tO\nIV\tO\nwere\tO\ninterviewed\tO\nusing\tO\nthe\tO\nMini\tO\nInternational\tO\nNeuropsychiatric\tO\nInterview\tO\n(\tO\nM\tO\n.\tO\nI\tO\n.\tO\nN\tO\n.\tO\nI\tO\n.\tO\n)\tO\nfor\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\nand\tO\nother\tO\nAxis\tO\nI\tO\npsychiatric\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nThe\tO\ninformation\tO\non\tO\nsociodemographic\tO\nbackground\tO\nand\tO\ndrug\tO\nuse\tO\nhistory\tO\nwas\tO\nobtained\tO\nfrom\tO\ninterview\tO\nor\tO\nmedical\tO\nrecords\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOf\tO\n292\tO\nsubjects\tO\n,\tO\n47\tO\n.\tO\n9\tO\n%\tO\nof\tO\nthe\tO\nsubjects\tO\nhad\tO\na\tO\npast\tO\nhistory\tO\nof\tO\npsychotic\tB-Disease\nsymptoms\tI-Disease\nand\tO\n13\tO\n.\tO\n0\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\nwere\tO\nhaving\tO\ncurrent\tO\npsychotic\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nCo\tO\n-\tO\nmorbid\tO\nmajor\tO\ndepressive\tB-Disease\ndisorder\tI-Disease\n(\tO\nOR\tO\n=\tO\n7\tO\n.\tO\n18\tO\n,\tO\n95\tO\nCI\tO\n=\tO\n2\tO\n.\tO\n612\tO\n-\tO\n19\tO\n.\tO\n708\tO\n)\tO\n,\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\n(\tO\nOR\tO\n=\tO\n13\tO\n.\tO\n807\tO\n,\tO\n95\tO\nCI\tO\n=\tO\n5\tO\n.\tO\n194\tO\n-\tO\n36\tO\n.\tO\n706\tO\n)\tO\n,\tO\nantisocial\tB-Disease\npersonality\tI-Disease\ndisorder\tI-Disease\n(\tO\nOR\tO\n=\tO\n12\tO\n.\tO\n619\tO\n,\tO\n95\tO\nCI\tO\n=\tO\n6\tO\n.\tO\n702\tO\n-\tO\n23\tO\n.\tO\n759\tO\n)\tO\nand\tO\nheavy\tO\nmethamphetamine\tB-Chemical\nuses\tO\nwere\tO\nsignificantly\tO\nassociated\tO\nwith\tO\nlifetime\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\nafter\tO\nadjusted\tO\nfor\tO\nother\tO\nfactors\tO\n.\tO\n\nMajor\tB-Disease\ndepressive\tI-Disease\ndisorder\tI-Disease\n(\tO\nOR\tO\n=\tO\n2\tO\n.\tO\n870\tO\n,\tO\nCI\tO\n=\tO\n1\tO\n.\tO\n154\tO\n-\tO\n7\tO\n.\tO\n142\tO\n)\tO\nand\tO\nantisocial\tB-Disease\npersonality\tI-Disease\ndisorder\tI-Disease\n(\tO\nOR\tO\n=\tO\n3\tO\n.\tO\n299\tO\n,\tO\n95\tO\nCI\tO\n=\tO\n1\tO\n.\tO\n375\tO\n-\tO\n7\tO\n.\tO\n914\tO\n)\tO\nwere\tO\nthe\tO\nonly\tO\nfactors\tO\nassociated\tO\nwith\tO\ncurrent\tO\npsychosis\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nThere\tO\nwas\tO\na\tO\nhigh\tO\nrisk\tO\nof\tO\npsychosis\tB-Disease\nin\tO\npatients\tO\nwith\tO\nmethamphetamine\tB-Chemical\ndependence\tO\n.\tO\n\nIt\tO\nwas\tO\nassociated\tO\nwith\tO\nco\tO\n-\tO\nmorbid\tO\naffective\tB-Disease\ndisorder\tI-Disease\n,\tO\nantisocial\tB-Disease\npersonality\tI-Disease\n,\tO\nand\tO\nheavy\tO\nmethamphetamine\tB-Chemical\nuse\tO\n.\tO\n\nIt\tO\nis\tO\nrecommended\tO\nthat\tO\nall\tO\ncases\tO\nof\tO\nmethamphetamine\tB-Chemical\ndependence\tO\nshould\tO\nbe\tO\nscreened\tO\nfor\tO\npsychotic\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nCerebellar\tO\nsensory\tO\nprocessing\tO\nalterations\tO\nimpact\tO\nmotor\tO\ncortical\tO\nplasticity\tO\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n:\tO\nclues\tO\nfrom\tO\ndyskinetic\tB-Disease\npatients\tO\n.\tO\n\nThe\tO\nplasticity\tO\nof\tO\nprimary\tO\nmotor\tO\ncortex\tO\n(\tO\nM1\tO\n)\tO\nin\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\nand\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n(\tO\nLIDs\tB-Disease\n)\tO\nis\tO\nseverely\tO\nimpaired\tO\n.\tO\n\nWe\tO\nrecently\tO\nreported\tO\nin\tO\nyoung\tO\nhealthy\tO\nsubjects\tO\nthat\tO\ninhibitory\tO\ncerebellar\tO\nstimulation\tO\nenhanced\tO\nthe\tO\nsensorimotor\tO\nplasticity\tO\nof\tO\nM1\tO\nthat\tO\nwas\tO\ninduced\tO\nby\tO\npaired\tO\nassociative\tO\nstimulation\tO\n(\tO\nPAS\tO\n)\tO\n.\tO\n\nThis\tO\nstudy\tO\ndemonstrates\tO\nthat\tO\nthe\tO\ndeficient\tO\nsensorimotor\tO\nM1\tO\nplasticity\tO\nin\tO\n16\tO\npatients\tO\nwith\tO\nLIDs\tB-Disease\ncould\tO\nbe\tO\nreinstated\tO\nby\tO\na\tO\nsingle\tO\nsession\tO\nof\tO\nreal\tO\ninhibitory\tO\ncerebellar\tO\nstimulation\tO\nbut\tO\nnot\tO\nsham\tO\nstimulation\tO\n.\tO\n\nThis\tO\nwas\tO\nevident\tO\nonly\tO\nwhen\tO\na\tO\nsensory\tO\ncomponent\tO\nwas\tO\ninvolved\tO\nin\tO\nthe\tO\ninduction\tO\nof\tO\nplasticity\tO\n,\tO\nindicating\tO\nthat\tO\ncerebellar\tO\nsensory\tO\nprocessing\tO\nfunction\tO\nis\tO\ninvolved\tO\nin\tO\nthe\tO\nresurgence\tO\nof\tO\nM1\tO\nplasticity\tO\n.\tO\n\nThe\tO\nbenefit\tO\nof\tO\ninhibitory\tO\ncerebellar\tO\nstimulation\tO\non\tO\nLIDs\tB-Disease\nis\tO\nknown\tO\n.\tO\n\nTo\tO\nexplore\tO\nwhether\tO\nthis\tO\nbenefit\tO\nis\tO\nlinked\tO\nto\tO\nthe\tO\nrestoration\tO\nof\tO\nsensorimotor\tO\nplasticity\tO\nof\tO\nM1\tO\n,\tO\nwe\tO\nconducted\tO\nan\tO\nadditional\tO\nstudy\tO\nlooking\tO\nat\tO\nchanges\tO\nin\tO\nLIDs\tB-Disease\nand\tO\nPAS\tO\n-\tO\ninduced\tO\nplasticity\tO\nafter\tO\n10\tO\nsessions\tO\nof\tO\neither\tO\nbilateral\tO\n,\tO\nreal\tO\ninhibitory\tO\ncerebellar\tO\nstimulation\tO\nor\tO\nsham\tO\nstimulation\tO\n.\tO\n\nOnly\tO\nreal\tO\nand\tO\nnot\tO\nsham\tO\nstimulation\tO\nhad\tO\nan\tO\nantidyskinetic\tO\neffect\tO\nand\tO\nit\tO\nwas\tO\nparalleled\tO\nby\tO\na\tO\nresurgence\tO\nin\tO\nthe\tO\nsensorimotor\tO\nplasticity\tO\nof\tO\nM1\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nalterations\tO\nin\tO\ncerebellar\tO\nsensory\tO\nprocessing\tO\nfunction\tO\n,\tO\noccurring\tO\nsecondary\tO\nto\tO\nabnormal\tO\nbasal\tO\nganglia\tO\nsignals\tO\nreaching\tO\nit\tO\n,\tO\nmay\tO\nbe\tO\nan\tO\nimportant\tO\nelement\tO\ncontributing\tO\nto\tO\nthe\tO\nmaladaptive\tO\nsensorimotor\tO\nplasticity\tO\nof\tO\nM1\tO\nand\tO\nthe\tO\nemergence\tO\nof\tO\nabnormal\tB-Disease\ninvoluntary\tI-Disease\nmovements\tI-Disease\n.\tO\n\nThe\tO\nlong\tO\n-\tO\nterm\tO\nsafety\tO\nof\tO\ndanazol\tB-Chemical\nin\tO\nwomen\tO\nwith\tO\nhereditary\tB-Disease\nangioedema\tI-Disease\n.\tO\n\nAlthough\tO\nthe\tO\nshort\tO\n-\tO\nterm\tO\nsafety\tO\n(\tO\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n6\tO\nmonths\tO\n)\tO\nof\tO\ndanazol\tB-Chemical\nhas\tO\nbeen\tO\nestablished\tO\nin\tO\na\tO\nvariety\tO\nof\tO\nsettings\tO\n,\tO\nno\tO\ninformation\tO\nexists\tO\nas\tO\nto\tO\nits\tO\nlong\tO\n-\tO\nterm\tO\nsafety\tO\n.\tO\n\nWe\tO\ntherefore\tO\ninvestigated\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nsafety\tO\nof\tO\ndanazol\tB-Chemical\nby\tO\nperforming\tO\na\tO\nretrospective\tO\nchart\tO\nreview\tO\nof\tO\n60\tO\nfemale\tO\npatients\tO\nwith\tO\nhereditary\tB-Disease\nangioedema\tI-Disease\ntreated\tO\nwith\tO\ndanazol\tB-Chemical\nfor\tO\na\tO\ncontinuous\tO\nperiod\tO\nof\tO\n6\tO\nmonths\tO\nor\tO\nlonger\tO\n.\tO\n\nThe\tO\nmean\tO\nage\tO\nof\tO\nthe\tO\npatients\tO\nwas\tO\n35\tO\n.\tO\n2\tO\nyears\tO\nand\tO\nthe\tO\nmean\tO\nduration\tO\nof\tO\ntherapy\tO\nwas\tO\n59\tO\n.\tO\n7\tO\nmonths\tO\n.\tO\n\nVirtually\tO\nall\tO\npatients\tO\nexperienced\tO\none\tO\nor\tO\nmore\tO\nadverse\tO\nreactions\tO\n.\tO\n\nMenstrual\tB-Disease\nabnormalities\tI-Disease\n(\tO\n79\tO\n%\tO\n)\tO\n,\tO\nweight\tB-Disease\ngain\tI-Disease\n(\tO\n60\tO\n%\tO\n)\tO\n,\tO\nmuscle\tB-Disease\ncramps\tI-Disease\n/\tO\nmyalgias\tB-Disease\n(\tO\n40\tO\n%\tO\n)\tO\n,\tO\nand\tO\ntransaminase\tO\nelevations\tO\n(\tO\n40\tO\n%\tO\n)\tO\nwere\tO\nthe\tO\nmost\tO\ncommon\tO\nadverse\tO\nreactions\tO\n.\tO\n\nThe\tO\ndrug\tO\nwas\tO\ndiscontinued\tO\ndue\tO\nto\tO\nadverse\tO\nreactions\tO\nin\tO\n8\tO\npatients\tO\n.\tO\n\nNo\tO\npatient\tO\nhas\tO\ndied\tO\nor\tO\nsuffered\tO\nany\tO\napparent\tO\nlong\tO\n-\tO\nterm\tO\nsequelae\tO\nthat\tO\nwere\tO\ndirectly\tO\nattributable\tO\nto\tO\nthe\tO\ndrug\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\n,\tO\ndespite\tO\na\tO\nrelatively\tO\nhigh\tO\nincidence\tO\nof\tO\nadverse\tO\nreactions\tO\n,\tO\ndanazol\tB-Chemical\nhas\tO\nproven\tO\nto\tO\nbe\tO\nremarkably\tO\nsafe\tO\nover\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nin\tO\nthis\tO\ngroup\tO\nof\tO\npatients\tO\n.\tO\n\nThe\tO\nfunction\tO\nof\tO\nP2X3\tO\nreceptor\tO\nand\tO\nNK1\tO\nreceptor\tO\nantagonists\tO\non\tO\ncyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nThe\tO\npurpose\tO\nof\tO\nthe\tO\nstudy\tO\nis\tO\nto\tO\nexplore\tO\nthe\tO\nfunction\tO\nof\tO\nP2X3\tO\nand\tO\nNK1\tO\nreceptors\tO\nantagonists\tO\non\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCYP\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncystitis\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nMETHODS\tO\n:\tO\nSixty\tO\nfemale\tO\nSprague\tO\n-\tO\nDawley\tO\n(\tO\nSD\tO\n)\tO\nrats\tO\nwere\tO\nrandomly\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n.\tO\n\nThe\tO\nrats\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\nwere\tO\nintraperitoneally\tO\n(\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\ninjected\tO\nwith\tO\n0\tO\n.\tO\n9\tO\n%\tO\nsaline\tO\n(\tO\n4\tO\nml\tO\n/\tO\nkg\tO\n)\tO\n;\tO\nthe\tO\nrats\tO\nin\tO\nthe\tO\nmodel\tO\ngroup\tO\nwere\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjected\tO\nwith\tO\nCYP\tB-Chemical\n(\tO\n150\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n;\tO\nand\tO\nthe\tO\nrats\tO\nin\tO\nthe\tO\nintervention\tO\ngroup\tO\nwere\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjected\tO\nwith\tO\nCYP\tB-Chemical\nwith\tO\nsubsequently\tO\nperfusion\tO\nof\tO\nbladder\tO\nwith\tO\nP2X3\tO\nand\tO\nNK1\tO\nreceptors\tO\n'\tO\nantagonists\tO\n,\tO\nSuramin\tB-Chemical\nand\tO\nGR\tB-Chemical\n82334\tI-Chemical\n.\tO\n\nSpontaneous\tO\npain\tB-Disease\nbehaviors\tO\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nCYP\tB-Chemical\nwere\tO\nobserved\tO\n.\tO\n\nUrodynamic\tO\nparameters\tO\n,\tO\nbladder\tO\npressure\tO\n-\tO\nvolume\tO\ncurve\tO\n,\tO\nmaximum\tO\nvoiding\tO\npressure\tO\n(\tO\nMVP\tO\n)\tO\n,\tO\nand\tO\nmaximum\tO\ncystometric\tO\ncapacity\tO\n(\tO\nMCC\tO\n)\tO\n,\tO\nwere\tO\nrecorded\tO\n.\tO\n\nPathological\tO\nchanges\tO\nin\tO\nbladder\tO\ntissue\tO\nwere\tO\nobserved\tO\n.\tO\n\nImmunofluorescence\tO\nwas\tO\nused\tO\nto\tO\ndetect\tO\nthe\tO\nexpression\tO\nof\tO\nP2X3\tO\nand\tO\nNK1\tO\nreceptors\tO\nin\tO\nbladder\tO\n.\tO\n\nRESULTS\tO\n:\tO\nCyclophosphamide\tB-Chemical\ntreatment\tO\nincreased\tO\nthe\tO\nspontaneous\tO\npain\tB-Disease\nbehaviors\tO\nscores\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nbladder\tO\ninstability\tO\nduring\tO\nurine\tO\nstorage\tO\nperiod\tO\nof\tO\nmodel\tO\ngroup\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nthan\tO\nintervention\tO\ngroup\tO\n(\tO\nX\tO\n(\tO\n2\tO\n)\tO\n=\tO\n7\tO\n.\tO\n619\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n007\tO\n)\tO\nand\tO\ncontrol\tO\ngroup\tO\n(\tO\nX\tO\n(\tO\n2\tO\n)\tO\n=\tO\n13\tO\n.\tO\n755\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n000\tO\n)\tO\n.\tO\n\nMCC\tO\nin\tO\nthe\tO\nmodel\tO\ngroup\tO\nwas\tO\nlower\tO\nthan\tO\nthe\tO\ncontrol\tO\nand\tO\nintervention\tO\ngroups\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nHistological\tO\nchanges\tO\nevident\tO\nin\tO\nmodel\tO\nand\tO\nintervention\tO\ngroups\tO\nrats\tO\n'\tO\nbladder\tO\nincluded\tO\nedema\tB-Disease\n,\tO\nvasodilation\tO\n,\tO\nand\tO\ninfiltration\tO\nof\tO\ninflammatory\tO\ncells\tO\n.\tO\n\nIn\tO\nmodel\tO\ngroup\tO\n,\tO\nthe\tO\nexpression\tO\nof\tO\nP2X3\tO\nreceptor\tO\nincreased\tO\nin\tO\nurothelium\tO\nand\tO\nsuburothelium\tO\n,\tO\nand\tO\nNK1\tO\nreceptor\tO\nincreased\tO\nin\tO\nsuburothelium\tO\n,\tO\nwhile\tO\nthe\tO\nexpression\tO\nof\tO\nthem\tO\nin\tO\nintervention\tO\ngroup\tO\nwas\tO\nlower\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\nCYP\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\n,\tO\nthe\tO\nexpression\tO\nof\tO\nP2X3\tO\nand\tO\nNK1\tO\nreceptors\tO\nincreased\tO\nin\tO\nurothelium\tO\nand\tO\n/\tO\nor\tO\nsuburothelium\tO\n.\tO\n\nPerfusion\tO\nof\tO\nbladder\tO\nwith\tO\nP2X3\tO\nand\tO\nNK1\tO\nreceptors\tO\nantagonists\tO\nameliorated\tO\nthe\tO\nbladder\tO\nfunction\tO\n.\tO\n\nPatient\tO\ntolerance\tO\nstudy\tO\nof\tO\ntopical\tO\nchlorhexidine\tB-Chemical\ndiphosphanilate\tI-Chemical\n:\tO\na\tO\nnew\tO\ntopical\tO\nagent\tO\nfor\tO\nburns\tB-Disease\n.\tO\n\nEffective\tO\ntopical\tO\nantimicrobial\tO\nagents\tO\ndecrease\tO\ninfection\tB-Disease\nand\tO\nmortality\tO\nin\tO\nburn\tB-Disease\npatients\tO\n.\tO\n\nChlorhexidine\tB-Chemical\nphosphanilate\tI-Chemical\n(\tO\nCHP\tB-Chemical\n)\tO\n,\tO\na\tO\nnew\tO\nbroad\tO\n-\tO\nspectrum\tO\nantimicrobial\tO\nagent\tO\n,\tO\nhas\tO\nbeen\tO\nevaluated\tO\nas\tO\na\tO\ntopical\tO\nburn\tB-Disease\nwound\tO\ndressing\tO\nin\tO\ncream\tO\nform\tO\n,\tO\nbut\tO\npreliminary\tO\nclinical\tO\ntrials\tO\nreported\tO\nthat\tO\nit\tO\nwas\tO\npainful\tO\nupon\tO\napplication\tO\n.\tO\n\nThis\tO\nstudy\tO\ncompared\tO\nvarious\tO\nconcentrations\tO\nof\tO\nCHP\tB-Chemical\nto\tO\ndetermine\tO\nif\tO\na\tO\ntolerable\tO\nconcentration\tO\ncould\tO\nbe\tO\nidentified\tO\nwith\tO\nretention\tO\nof\tO\nantimicrobial\tO\nefficacy\tO\n.\tO\n\nTwenty\tO\n-\tO\nnine\tO\nburn\tB-Disease\npatients\tO\n,\tO\neach\tO\nwith\tO\ntwo\tO\nsimilar\tO\nburns\tB-Disease\nwhich\tO\ncould\tO\nbe\tO\nseparately\tO\ntreated\tO\n,\tO\nwere\tO\ngiven\tO\npairs\tO\nof\tO\ntreatments\tO\nat\tO\nsuccessive\tO\n12\tO\n-\tO\nh\tO\nintervals\tO\nover\tO\na\tO\n3\tO\n-\tO\nday\tO\nperiod\tO\n.\tO\n\nOne\tO\nburn\tB-Disease\nsite\tO\nwas\tO\ntreated\tO\nwith\tO\neach\tO\nof\tO\nfour\tO\ndifferent\tO\nCHP\tB-Chemical\nconcentrations\tO\n,\tO\nfrom\tO\n0\tO\n.\tO\n25\tO\nper\tO\ncent\tO\nto\tO\n2\tO\nper\tO\ncent\tO\n,\tO\ntheir\tO\nvehicle\tO\n,\tO\nand\tO\n1\tO\nper\tO\ncent\tO\nsilver\tB-Chemical\nsulphadiazine\tI-Chemical\n(\tO\nAgSD\tB-Chemical\n)\tO\ncream\tO\n,\tO\nan\tO\nantimicrobial\tO\nagent\tO\nfrequently\tO\nused\tO\nfor\tO\ntopical\tO\ntreatment\tO\nof\tO\nburn\tB-Disease\nwounds\tO\n.\tO\n\nThe\tO\nother\tO\nsite\tO\nwas\tO\nalways\tO\ntreated\tO\nwith\tO\nAgSD\tB-Chemical\ncream\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\ndirect\tO\nrelationship\tO\nbetween\tO\nCHP\tB-Chemical\nconcentration\tO\nand\tO\npatients\tO\n'\tO\nratings\tO\nof\tO\npain\tB-Disease\non\tO\nan\tO\nanalogue\tO\nscale\tO\n.\tO\n\nThe\tO\n0\tO\n.\tO\n25\tO\nper\tO\ncent\tO\nCHP\tB-Chemical\ncream\tO\nwas\tO\nclosest\tO\nto\tO\nAgSD\tB-Chemical\nin\tO\npain\tB-Disease\ntolerance\tO\n;\tO\nhowever\tO\n,\tO\nnone\tO\nof\tO\nthe\tO\ntreatments\tO\ndiffered\tO\nstatistically\tO\nfrom\tO\nAgSD\tB-Chemical\nor\tO\nfrom\tO\neach\tO\nother\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nease\tO\nof\tO\napplication\tO\nof\tO\nCHP\tB-Chemical\ncreams\tO\nwas\tO\nless\tO\nsatisfactory\tO\nthan\tO\nthat\tO\nof\tO\nAgSD\tB-Chemical\n.\tO\n\nIt\tO\nwas\tO\nconcluded\tO\nthat\tO\nformulations\tO\nat\tO\nor\tO\nbelow\tO\n0\tO\n.\tO\n5\tO\nper\tO\ncent\tO\nCHP\tB-Chemical\nmay\tO\nprove\tO\nacceptable\tO\nfor\tO\nwound\tO\ncare\tO\n,\tO\nbut\tO\nthe\tO\nvehicle\tO\nsystem\tO\nneeds\tO\npharmaceutical\tO\nimprovement\tO\nto\tO\nrender\tO\nit\tO\nmore\tO\ntolerable\tO\nand\tO\neasier\tO\nto\tO\nuse\tO\n.\tO\n\nAcute\tO\nhepatitis\tB-Disease\nassociated\tO\nwith\tO\nclopidogrel\tB-Chemical\n:\tO\na\tO\ncase\tO\nreport\tO\nand\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\n.\tO\n\nDrug\tO\n-\tO\ninduced\tO\nhepatotoxicity\tB-Disease\nis\tO\na\tO\ncommon\tO\ncause\tO\nof\tO\nacute\tO\nhepatitis\tB-Disease\n,\tO\nand\tO\nthe\tO\nrecognition\tO\nof\tO\nthe\tO\nresponsible\tO\ndrug\tO\nmay\tO\nbe\tO\ndifficult\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\nclopidogrel\tB-Chemical\n-\tO\nrelated\tO\nacute\tO\nhepatitis\tB-Disease\n.\tO\n\nThe\tO\ndiagnosis\tO\nis\tO\nstrongly\tO\nsuggested\tO\nby\tO\nan\tO\naccurate\tO\nmedical\tO\nhistory\tO\nand\tO\nliver\tO\nbiopsy\tO\n.\tO\n\nReports\tO\nabout\tO\ncases\tO\nof\tO\nhepatotoxicity\tB-Disease\ndue\tO\nto\tO\nclopidogrel\tB-Chemical\nare\tO\nincreasing\tO\nin\tO\nthe\tO\nlast\tO\nfew\tO\nyears\tO\n,\tO\nafter\tO\nthe\tO\nincreased\tO\nuse\tO\nof\tO\nthis\tO\ndrug\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nwe\tO\nbelieve\tO\nthat\tO\nphysicians\tO\nshould\tO\ncarefully\tO\nconsider\tO\nthe\tO\nrisk\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nhepatic\tB-Disease\ninjury\tI-Disease\nwhen\tO\nclopidogrel\tB-Chemical\nis\tO\nprescribed\tO\n.\tO\n\nBortezomib\tB-Chemical\nand\tO\ndexamethasone\tB-Chemical\nas\tO\nsalvage\tO\ntherapy\tO\nin\tO\npatients\tO\nwith\tO\nrelapsed\tO\n/\tO\nrefractory\tO\nmultiple\tB-Disease\nmyeloma\tI-Disease\n:\tO\nanalysis\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nclinical\tO\noutcomes\tO\n.\tO\n\nBortezomib\tB-Chemical\n(\tO\nbort\tB-Chemical\n)\tO\n-\tO\ndexamethasone\tB-Chemical\n(\tO\ndex\tB-Chemical\n)\tO\nis\tO\nan\tO\neffective\tO\ntherapy\tO\nfor\tO\nrelapsed\tO\n/\tO\nrefractory\tO\n(\tO\nR\tO\n/\tO\nR\tO\n)\tO\nmultiple\tB-Disease\nmyeloma\tI-Disease\n(\tO\nMM\tB-Disease\n)\tO\n.\tO\n\nThis\tO\nretrospective\tO\nstudy\tO\ninvestigated\tO\nthe\tO\ncombination\tO\nof\tO\nbort\tB-Chemical\n(\tO\n1\tO\n.\tO\n3\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\non\tO\ndays\tO\n1\tO\n,\tO\n4\tO\n,\tO\n8\tO\n,\tO\nand\tO\n11\tO\nevery\tO\n3\tO\nweeks\tO\n)\tO\nand\tO\ndex\tB-Chemical\n(\tO\n20\tO\nmg\tO\non\tO\nthe\tO\nday\tO\nof\tO\nand\tO\nthe\tO\nday\tO\nafter\tO\nbort\tB-Chemical\n)\tO\nas\tO\nsalvage\tO\ntreatment\tO\nin\tO\n85\tO\npatients\tO\nwith\tO\nR\tO\n/\tO\nR\tO\nMM\tB-Disease\nafter\tO\nprior\tO\nautologous\tO\nstem\tO\ncell\tO\ntransplantation\tO\nor\tO\nconventional\tO\nchemotherapy\tO\n.\tO\n\nThe\tO\nmedian\tO\nnumber\tO\nof\tO\nprior\tO\nlines\tO\nof\tO\ntherapy\tO\nwas\tO\n2\tO\n.\tO\n\nEighty\tO\n-\tO\nseven\tO\npercent\tO\nof\tO\nthe\tO\npatients\tO\nhad\tO\nreceived\tO\nimmunomodulatory\tO\ndrugs\tO\nincluded\tO\nin\tO\nsome\tO\nline\tO\nof\tO\ntherapy\tO\nbefore\tO\nbort\tB-Chemical\n-\tO\ndex\tB-Chemical\n.\tO\n\nThe\tO\nmedian\tO\nnumber\tO\nof\tO\nbort\tB-Chemical\n-\tO\ndex\tB-Chemical\ncycles\tO\nwas\tO\n6\tO\n,\tO\nup\tO\nto\tO\na\tO\nmaximum\tO\nof\tO\n12\tO\ncycles\tO\n.\tO\n\nOn\tO\nan\tO\nintention\tO\n-\tO\nto\tO\n-\tO\ntreat\tO\nbasis\tO\n,\tO\n55\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\nachieved\tO\nat\tO\nleast\tO\npartial\tO\nresponse\tO\n,\tO\nincluding\tO\n19\tO\n%\tO\nCR\tO\nand\tO\n35\tO\n%\tO\nachieved\tO\nat\tO\nleast\tO\nvery\tO\ngood\tO\npartial\tO\nresponse\tO\n.\tO\n\nMedian\tO\ndurations\tO\nof\tO\nresponse\tO\n,\tO\ntime\tO\nto\tO\nnext\tO\ntherapy\tO\nand\tO\ntreatment\tO\n-\tO\nfree\tO\ninterval\tO\nwere\tO\n8\tO\n,\tO\n11\tO\n.\tO\n2\tO\n,\tO\nand\tO\n5\tO\n.\tO\n1\tO\nmonths\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nmost\tO\nrelevant\tO\nadverse\tO\nevent\tO\nwas\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\n,\tO\nwhich\tO\noccurred\tO\nin\tO\n78\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\n(\tO\ngrade\tO\nII\tO\n,\tO\n38\tO\n%\tO\n;\tO\ngrade\tO\nIII\tO\n,\tO\n21\tO\n%\tO\n)\tO\nand\tO\nled\tO\nto\tO\ntreatment\tO\ndiscontinuation\tO\nin\tO\n6\tO\n%\tO\n.\tO\n\nWith\tO\na\tO\nmedian\tO\nfollow\tO\nup\tO\nof\tO\n22\tO\nmonths\tO\n,\tO\nmedian\tO\ntime\tO\nto\tO\nprogression\tO\n,\tO\nprogression\tO\n-\tO\nfree\tO\nsurvival\tO\n(\tO\nPFS\tO\n)\tO\nand\tO\noverall\tO\nsurvival\tO\n(\tO\nOS\tO\n)\tO\nwere\tO\n8\tO\n.\tO\n9\tO\n,\tO\n8\tO\n.\tO\n7\tO\n,\tO\nand\tO\n22\tO\nmonths\tO\n,\tO\nrespectively\tO\n.\tO\n\nProlonged\tO\nPFS\tO\nand\tO\nOS\tO\nwere\tO\nobserved\tO\nin\tO\npatients\tO\nachieving\tO\nCR\tO\nand\tO\nreceiving\tO\nbort\tB-Chemical\n-\tO\ndex\tB-Chemical\na\tO\nsingle\tO\nline\tO\nof\tO\nprior\tO\ntherapy\tO\n.\tO\n\nBort\tB-Chemical\n-\tO\ndex\tB-Chemical\nwas\tO\nan\tO\neffective\tO\nsalvage\tO\ntreatment\tO\nfor\tO\nMM\tB-Disease\npatients\tO\n,\tO\nparticularly\tO\nfor\tO\nthose\tO\nin\tO\nfirst\tO\nrelapse\tO\n.\tO\n\nPubertal\tO\nexposure\tO\nto\tO\nBisphenol\tB-Chemical\nA\tI-Chemical\nincreases\tO\nanxiety\tB-Disease\n-\tO\nlike\tO\nbehavior\tO\nand\tO\ndecreases\tO\nacetylcholinesterase\tO\nactivity\tO\nof\tO\nhippocampus\tO\nin\tO\nadult\tO\nmale\tO\nmice\tO\n.\tO\n\nThe\tO\nnegative\tO\neffects\tO\nof\tO\nBisphenol\tB-Chemical\nA\tI-Chemical\n(\tO\nBPA\tB-Chemical\n)\tO\non\tO\nneurodevelopment\tO\nand\tO\nbehaviors\tO\nhave\tO\nbeen\tO\nwell\tO\nestablished\tO\n.\tO\n\nAcetylcholinesterase\tO\n(\tO\nAChE\tO\n)\tO\nis\tO\na\tO\nregulatory\tO\nenzyme\tO\nwhich\tO\nis\tO\ninvolved\tO\nin\tO\nanxiety\tB-Disease\n-\tO\nlike\tO\nbehavior\tO\n.\tO\n\nThis\tO\nstudy\tO\ninvestigated\tO\nbehavioral\tO\nphenotypes\tO\nand\tO\nAChE\tO\nactivity\tO\nin\tO\nmale\tO\nmice\tO\nfollowing\tO\nBPA\tB-Chemical\nexposure\tO\nduring\tO\npuberty\tO\n.\tO\n\nOn\tO\npostnatal\tO\nday\tO\n(\tO\nPND\tO\n)\tO\n35\tO\n,\tO\nmale\tO\nmice\tO\nwere\tO\nexposed\tO\nto\tO\n50mg\tO\nBPA\tB-Chemical\n/\tO\nkg\tO\ndiet\tO\nper\tO\nday\tO\nfor\tO\na\tO\nperiod\tO\nof\tO\n35\tO\ndays\tO\n.\tO\n\nOn\tO\nPND71\tO\n,\tO\na\tO\nbehavioral\tO\nassay\tO\nwas\tO\nperformed\tO\nusing\tO\nthe\tO\nelevated\tO\nplus\tO\nmaze\tO\n(\tO\nEPM\tO\n)\tO\nand\tO\nthe\tO\nlight\tO\n/\tO\ndark\tO\ntest\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nAChE\tO\nactivity\tO\nwas\tO\nmeasured\tO\nin\tO\nthe\tO\nprefrontal\tO\ncortex\tO\n,\tO\nhypothalamus\tO\n,\tO\ncerebellum\tO\nand\tO\nhippocampus\tO\n.\tO\n\nResults\tO\nfrom\tO\nour\tO\nbehavioral\tO\nphenotyping\tO\nindicated\tO\nthat\tO\nanxiety\tB-Disease\n-\tO\nlike\tO\nbehavior\tO\nwas\tO\nincreased\tO\nin\tO\nmice\tO\nexposed\tO\nto\tO\nBPA\tB-Chemical\n.\tO\n\nAChE\tO\nactivity\tO\nwas\tO\nsignificantly\tO\ndecreased\tO\nin\tO\nthe\tO\nhippocampus\tO\nof\tO\nmice\tO\nwith\tO\nBPA\tB-Chemical\ncompared\tO\nto\tO\ncontrol\tO\nmice\tO\n,\tO\nwhereas\tO\nno\tO\ndifference\tO\nwas\tO\nfound\tO\nin\tO\nthe\tO\nprefrontal\tO\ncortex\tO\n,\tO\nhypothalamus\tO\nand\tO\ncerebellum\tO\n.\tO\n\nOur\tO\nfindings\tO\nshowed\tO\nthat\tO\npubertal\tO\nBPA\tB-Chemical\nexposure\tO\nincreased\tO\nanxiety\tB-Disease\n-\tO\nlike\tO\nbehavior\tO\n,\tO\nwhich\tO\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\ndecreased\tO\nAChE\tO\nactivity\tO\nof\tO\nthe\tO\nhippocampus\tO\nin\tO\nadult\tO\nmale\tO\nmice\tO\n.\tO\n\nFurther\tO\nstudies\tO\nare\tO\nnecessary\tO\nto\tO\ninvestigate\tO\nthe\tO\ncholinergic\tO\nsignaling\tO\nof\tO\nthe\tO\nhippocampus\tO\nin\tO\nPBE\tO\ninduced\tO\nanxiety\tB-Disease\n-\tO\nlike\tO\nbehaviors\tO\n.\tO\n\nBiochemical\tO\neffects\tO\nof\tO\nSolidago\tO\nvirgaurea\tO\nextract\tO\non\tO\nexperimental\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nCardiovascular\tB-Disease\ndiseases\tI-Disease\n(\tO\nCVDs\tB-Disease\n)\tO\nare\tO\nthe\tO\nmajor\tO\nhealth\tO\nproblem\tO\nof\tO\nadvanced\tO\nas\tO\nwell\tO\nas\tO\ndeveloping\tO\ncountries\tO\nof\tO\nthe\tO\nworld\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthe\tO\nprotective\tO\neffect\tO\nof\tO\nthe\tO\nSolidago\tO\nvirgaurea\tO\nextract\tO\non\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nsubcutaneous\tO\ninjection\tO\nof\tO\nisoproterenol\tB-Chemical\n(\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ninto\tO\nrats\tO\ntwice\tO\nat\tO\nan\tO\ninterval\tO\nof\tO\n24\tO\nh\tO\n,\tO\nfor\tO\ntwo\tO\nconsecutive\tO\ndays\tO\n,\tO\nled\tO\nto\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nserum\tO\nlactate\tB-Chemical\ndehydrogenase\tO\n,\tO\ncreatine\tB-Chemical\nphosphokinase\tO\n,\tO\nalanine\tB-Chemical\ntransaminase\tO\n,\tO\naspartate\tB-Chemical\ntransaminase\tO\n,\tO\nand\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\nactivities\tO\n,\tO\ntotal\tO\ncholesterol\tB-Chemical\n,\tO\ntriglycerides\tB-Chemical\n,\tO\nfree\tO\nserum\tO\nfatty\tB-Chemical\nacid\tI-Chemical\n,\tO\ncardiac\tO\ntissue\tO\nmalondialdehyde\tB-Chemical\n(\tO\nMDA\tB-Chemical\n)\tO\n,\tO\nand\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nlevels\tO\nand\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nlevels\tO\nof\tO\nglutathione\tB-Chemical\nand\tO\nsuperoxide\tB-Chemical\ndismutase\tO\nin\tO\ncardiac\tO\ntissue\tO\nas\tO\ncompared\tO\nto\tO\nthe\tO\nnormal\tO\ncontrol\tO\ngroup\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nPretreatment\tO\nwith\tO\nS\tO\n.\tO\nvirgaurea\tO\nextract\tO\nfor\tO\n5\tO\nweeks\tO\nat\tO\na\tO\ndose\tO\nof\tO\n250\tO\nmg\tO\n/\tO\nkg\tO\nfollowed\tO\nby\tO\nisoproterenol\tB-Chemical\ninjection\tO\nsignificantly\tO\nprevented\tO\nthe\tO\nobserved\tO\nalterations\tO\n.\tO\n\nCaptopril\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n,\tO\ngiven\tO\norally\tO\n)\tO\n,\tO\nan\tO\ninhibitor\tO\nof\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\nused\tO\nas\tO\na\tO\nstandard\tO\ncardioprotective\tO\ndrug\tO\n,\tO\nwas\tO\nused\tO\nas\tO\na\tO\npositive\tO\ncontrol\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nThe\tO\ndata\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nsuggest\tO\nthat\tO\nS\tO\n.\tO\nvirgaurea\tO\nextract\tO\nexerts\tO\nits\tO\nprotective\tO\neffect\tO\nby\tO\ndecreasing\tO\nMDA\tB-Chemical\nlevel\tO\nand\tO\nincreasing\tO\nthe\tO\nantioxidant\tO\nstatus\tO\nin\tO\nisoproterenol\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nThe\tO\nstudy\tO\nemphasizes\tO\nthe\tO\nbeneficial\tO\naction\tO\nof\tO\nS\tO\n.\tO\nvirgaurea\tO\nextract\tO\nas\tO\na\tO\ncardioprotective\tO\nagent\tO\n.\tO\n\n\"\tO\nReal\tO\n-\tO\nworld\tO\n\"\tO\ndata\tO\non\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\nlenalidomide\tB-Chemical\nand\tO\ndexamethasone\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nrelapsed\tO\n/\tO\nrefractory\tO\nmultiple\tB-Disease\nmyeloma\tI-Disease\nwho\tO\nwere\tO\ntreated\tO\naccording\tO\nto\tO\nthe\tO\nstandard\tO\nclinical\tO\npractice\tO\n:\tO\na\tO\nstudy\tO\nof\tO\nthe\tO\nGreek\tO\nMyeloma\tB-Disease\nStudy\tO\nGroup\tO\n.\tO\n\nLenalidomide\tB-Chemical\nand\tO\ndexamethasone\tB-Chemical\n(\tO\nRD\tB-Chemical\n)\tO\nis\tO\na\tO\nstandard\tO\nof\tO\ncare\tO\nfor\tO\nrelapsed\tO\n/\tO\nrefractory\tO\nmultiple\tB-Disease\nmyeloma\tI-Disease\n(\tO\nRRMM\tB-Disease\n)\tO\n,\tO\nbut\tO\nthere\tO\nis\tO\nlimited\tO\npublished\tO\ndata\tO\non\tO\nits\tO\nefficacy\tO\nand\tO\nsafety\tO\nin\tO\nthe\tO\n\"\tO\nreal\tO\nworld\tO\n\"\tO\n(\tO\nRW\tO\n)\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\nInternational\tO\nSociety\tO\nof\tO\nPharmacoeconomics\tO\nand\tO\nOutcomes\tO\nResearch\tO\ndefinition\tO\n.\tO\n\nWe\tO\nstudied\tO\n212\tO\nRRMM\tB-Disease\npatients\tO\nwho\tO\nreceived\tO\nRD\tB-Chemical\nin\tO\nRW\tO\n.\tO\n\nObjective\tO\nresponse\tO\n(\tO\n>\tO\nPR\tO\n(\tO\npartial\tO\nresponse\tO\n)\tO\n)\tO\nrate\tO\nwas\tO\n77\tO\n.\tO\n4\tO\n%\tO\n(\tO\ncomplete\tO\nresponse\tO\n(\tO\nCR\tO\n)\tO\n,\tO\n20\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nMedian\tO\ntime\tO\nto\tO\nfirst\tO\nand\tO\nbest\tO\nresponse\tO\nwas\tO\n2\tO\nand\tO\n5\tO\nmonths\tO\n,\tO\nrespectively\tO\n.\tO\n\nMedian\tO\ntime\tO\nto\tO\nCR\tO\nwhen\tO\nRD\tB-Chemical\nwas\tO\ngiven\tO\nas\tO\n2nd\tO\nor\tO\n>\tO\n2\tO\n(\tO\nnd\tO\n)\tO\n-\tO\nline\tO\ntreatment\tO\nat\tO\n4\tO\nand\tO\n11\tO\nmonths\tO\n,\tO\nrespectively\tO\n.\tO\n\nQuality\tO\nof\tO\nresponse\tO\nwas\tO\nindependent\tO\nof\tO\nprevious\tO\nlines\tO\nof\tO\ntherapies\tO\nor\tO\nprevious\tO\nexposure\tO\nto\tO\nthalidomide\tB-Chemical\nor\tO\nbortezomib\tB-Chemical\n.\tO\n\nMedian\tO\nduration\tO\nof\tO\nresponse\tO\nwas\tO\n34\tO\n.\tO\n4\tO\nmonths\tO\n,\tO\nand\tO\nit\tO\nwas\tO\nhigher\tO\nin\tO\npatients\tO\nwho\tO\nreceived\tO\nRD\tB-Chemical\nuntil\tO\nprogression\tO\n(\tO\nnot\tO\nreached\tO\nversus\tO\n19\tO\nmonths\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nImprovement\tO\nof\tO\nhumoral\tO\nimmunity\tO\noccurred\tO\nin\tO\n60\tO\n%\tO\nof\tO\nresponders\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\nin\tO\nthe\tO\nmajority\tO\nof\tO\npatients\tO\nwho\tO\nachieved\tO\nstable\tO\ndisease\tO\n.\tO\n\nAdverse\tO\nevents\tO\nwere\tO\nreported\tO\nin\tO\n68\tO\n.\tO\n9\tO\n%\tO\nof\tO\npatients\tO\n(\tO\nmyelosuppression\tB-Disease\nin\tO\n49\tO\n.\tO\n4\tO\n%\tO\n)\tO\nand\tO\n12\tO\n.\tO\n7\tO\n%\tO\nof\tO\npatients\tO\nneeded\tO\nhospitalization\tO\n.\tO\n\nPeripheral\tB-Disease\nneuropathy\tI-Disease\nwas\tO\nobserved\tO\nonly\tO\nin\tO\n2\tO\n.\tO\n5\tO\n%\tO\nof\tO\npatients\tO\nand\tO\ndeep\tB-Disease\nvein\tI-Disease\nthrombosis\tI-Disease\nin\tO\n5\tO\n.\tO\n7\tO\n%\tO\n.\tO\n\nDose\tO\nreductions\tO\nwere\tO\nneeded\tO\nin\tO\n31\tO\n%\tO\nof\tO\npatients\tO\nand\tO\npermanent\tO\ndiscontinuation\tO\nin\tO\n38\tO\n.\tO\n9\tO\n%\tO\n.\tO\n\nMedian\tO\ntime\tO\nto\tO\ntreatment\tO\ndiscontinuation\tO\nwas\tO\n16\tO\n.\tO\n8\tO\nmonths\tO\n.\tO\n\nPerformance\tO\nstatus\tO\n(\tO\nPS\tO\n)\tO\nand\tO\ninitial\tO\nlenalidomide\tB-Chemical\ndose\tO\npredicted\tO\nfor\tO\ntreatment\tO\ndiscontinuation\tO\n.\tO\n\nExtra\tO\n-\tO\nmedullary\tO\nrelapses\tO\noccurred\tO\nin\tO\n3\tO\n.\tO\n8\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nOur\tO\nstudy\tO\nconfirms\tO\nthat\tO\nRD\tB-Chemical\nis\tO\neffective\tO\nand\tO\nsafe\tO\nin\tO\nRRMM\tB-Disease\nin\tO\nthe\tO\nRW\tO\n;\tO\nit\tO\nproduces\tO\ndurable\tO\nresponses\tO\nespecially\tO\nin\tO\npatients\tO\nwho\tO\ncontinue\tO\non\tO\ntreatment\tO\ntill\tO\nprogression\tO\nand\tO\nimproves\tO\nhumoral\tO\nimmunity\tO\neven\tO\nin\tO\npatients\tO\nwith\tO\nstable\tO\ndisease\tO\n.\tO\n\nThe\tO\ncytogenetic\tO\naction\tO\nof\tO\nifosfamide\tB-Chemical\n,\tO\nmesna\tB-Chemical\n,\tO\nand\tO\ntheir\tO\ncombination\tO\non\tO\nperipheral\tO\nrabbit\tO\nlymphocytes\tO\n:\tO\nan\tO\nin\tO\nvivo\tO\n/\tO\nin\tO\nvitro\tO\ncytogenetic\tO\nstudy\tO\n.\tO\n\nIfosfamide\tB-Chemical\n(\tO\nIFO\tB-Chemical\n)\tO\nis\tO\nan\tO\nalkylating\tO\nnitrogen\tB-Chemical\nmustard\tO\n,\tO\nadministrated\tO\nas\tO\nan\tO\nantineoplasmic\tO\nagent\tO\n.\tO\n\nIt\tO\nis\tO\ncharacterized\tO\nby\tO\nits\tO\nintense\tO\nurotoxic\tO\naction\tO\n,\tO\nleading\tO\nto\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nThis\tO\nside\tO\neffect\tO\nof\tO\nIFO\tB-Chemical\nraises\tO\nthe\tO\nrequirement\tO\nfor\tO\nthe\tO\nco\tO\n-\tO\nadministration\tO\nwith\tO\nsodium\tB-Chemical\n2\tI-Chemical\n-\tI-Chemical\nsulfanylethanesulfonate\tI-Chemical\n(\tO\nMesna\tB-Chemical\n)\tO\naiming\tO\nto\tO\navoid\tO\nor\tO\nminimize\tO\nthis\tO\neffect\tO\n.\tO\n\nIFO\tB-Chemical\nand\tO\nMesna\tB-Chemical\nwere\tO\nadministrated\tO\nseparately\tO\non\tO\nrabbit\tO\n'\tO\ns\tO\nlymphocytes\tO\nin\tO\nvivo\tO\n,\tO\nwhich\tO\nwere\tO\nlater\tO\ndeveloped\tO\nin\tO\nvitro\tO\n.\tO\n\nCytogenetic\tO\nmarkers\tO\nfor\tO\nsister\tO\nchromatid\tO\nexchanges\tO\n(\tO\nSCEs\tO\n)\tO\n,\tO\nproliferation\tO\nrate\tO\nindex\tO\n(\tO\nPRI\tO\n)\tO\nand\tO\nMitotic\tO\nIndex\tO\nwere\tO\nrecorded\tO\n.\tO\n\nMesna\tB-Chemical\n'\tO\ns\tO\naction\tO\n,\tO\nin\tO\nconjunction\tO\nwith\tO\nIFO\tB-Chemical\nreduces\tO\nthe\tO\nfrequency\tO\nof\tO\nSCEs\tO\n,\tO\nin\tO\ncomparison\tO\nwith\tO\nthe\tO\nSCEs\tO\nrecordings\tO\nobtained\tO\nwhen\tO\nIFO\tB-Chemical\nis\tO\nadministered\tO\nalone\tO\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nthis\tO\n,\tO\nwhen\tO\nhigh\tO\nconcentrations\tO\nof\tO\nMesna\tB-Chemical\nwere\tO\nadministered\tO\nalone\tO\nsignificant\tO\nreductions\tO\nof\tO\nthe\tO\nPRI\tO\nwere\tO\nnoted\tO\n,\tO\nthan\tO\nwith\tO\nIFO\tB-Chemical\nacting\tO\nat\tO\nthe\tO\nsame\tO\nconcentration\tO\non\tO\nthe\tO\nlymphocytes\tO\n.\tO\n\nMesna\tB-Chemical\nsignificantly\tO\nreduces\tO\nIFO\tB-Chemical\n'\tO\ns\tO\ngenotoxicity\tB-Disease\n,\tO\nwhile\tO\nwhen\tO\nadministered\tO\nin\tO\nhigh\tO\nconcentrations\tO\nit\tO\nacts\tO\nin\tO\nan\tO\ninhibitory\tO\nfashion\tO\non\tO\nthe\tO\ncytostatic\tO\naction\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nRisk\tO\nfactors\tO\nand\tO\npredictors\tO\nof\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\namong\tO\nmultiethnic\tO\nMalaysians\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nChronic\tO\npulsatile\tO\nlevodopa\tB-Chemical\ntherapy\tO\nfor\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\nleads\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\nmotor\tO\nfluctuations\tO\nand\tO\ndyskinesia\tB-Disease\n.\tO\n\nWe\tO\nstudied\tO\nthe\tO\nprevalence\tO\nand\tO\npredictors\tO\nof\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\namong\tO\nmultiethnic\tO\nMalaysian\tO\npatients\tO\nwith\tO\nPD\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nis\tO\na\tO\ncross\tO\n-\tO\nsectional\tO\nstudy\tO\ninvolving\tO\n95\tO\npatients\tO\nwith\tO\nPD\tB-Disease\non\tO\nuninterrupted\tO\nlevodopa\tB-Chemical\ntherapy\tO\nfor\tO\nat\tO\nleast\tO\n6\tO\nmonths\tO\n.\tO\n\nThe\tO\ninstrument\tO\nused\tO\nwas\tO\nthe\tO\nUPDRS\tO\nquestionnaires\tO\n.\tO\n\nThe\tO\npredictors\tO\nof\tO\ndyskinesia\tB-Disease\nwere\tO\ndetermined\tO\nusing\tO\nmultivariate\tO\nlogistic\tO\nregression\tO\nanalysis\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nmean\tO\nage\tO\nwas\tO\n65\tO\n.\tO\n6\tO\n+\tO\n8\tO\n.\tO\n5\tO\nyears\tO\n.\tO\n\nThe\tO\nmean\tO\nonset\tO\nage\tO\nwas\tO\n58\tO\n.\tO\n5\tO\n+\tO\n9\tO\n.\tO\n8\tO\nyears\tO\n.\tO\n\nThe\tO\nmedian\tO\ndisease\tO\nduration\tO\nwas\tO\n6\tO\n(\tO\n7\tO\n)\tO\nyears\tO\n.\tO\n\nDyskinesia\tB-Disease\nwas\tO\npresent\tO\nin\tO\n44\tO\n%\tO\n(\tO\nn\tO\n=\tO\n42\tO\n)\tO\nwith\tO\nmedian\tO\nlevodopa\tB-Chemical\ntherapy\tO\nof\tO\n3\tO\nyears\tO\n.\tO\n\nThere\tO\nwere\tO\n64\tO\n.\tO\n3\tO\n%\tO\nChinese\tO\n,\tO\n31\tO\n%\tO\nMalays\tO\n,\tO\nand\tO\n3\tO\n.\tO\n7\tO\n%\tO\nIndians\tO\nand\tO\nother\tO\nethnic\tO\ngroups\tO\n.\tO\n\nEighty\tO\n-\tO\none\tO\npercent\tO\nof\tO\npatients\tO\nwith\tO\ndyskinesia\tB-Disease\nhad\tO\nclinical\tO\nfluctuations\tO\n.\tO\n\nPatients\tO\nwith\tO\ndyskinesia\tB-Disease\nhad\tO\nlower\tO\nonset\tO\nage\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nlonger\tO\nduration\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nlonger\tO\ndisease\tO\nduration\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nhigher\tO\ntotal\tO\ndaily\tO\nlevodopa\tB-Chemical\ndose\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nand\tO\nhigher\tO\ntotal\tO\nUPDRS\tO\nscores\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n005\tO\n)\tO\nthan\tO\npatients\tO\nwithout\tO\ndyskinesia\tB-Disease\n.\tO\n\nThe\tO\nthree\tO\nsignificant\tO\npredictors\tO\nof\tO\ndyskinesia\tB-Disease\nwere\tO\nduration\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\n,\tO\nonset\tO\nage\tO\n,\tO\nand\tO\ntotal\tO\ndaily\tO\nlevodopa\tB-Chemical\ndose\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nprevalence\tO\nof\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\nin\tO\nour\tO\npatients\tO\nwas\tO\n44\tO\n%\tO\n.\tO\n\nThe\tO\nmost\tO\nsignificant\tO\npredictors\tO\nwere\tO\nduration\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\n,\tO\ntotal\tO\ndaily\tO\nlevodopa\tB-Chemical\ndose\tO\n,\tO\nand\tO\nonset\tO\nage\tO\n.\tO\n\nDose\tO\n-\tO\ndependent\tO\nneurotoxicity\tB-Disease\nof\tO\nhigh\tO\n-\tO\ndose\tO\nbusulfan\tB-Chemical\nin\tO\nchildren\tO\n:\tO\na\tO\nclinical\tO\nand\tO\npharmacological\tO\nstudy\tO\n.\tO\n\nBusulfan\tB-Chemical\nis\tO\nknown\tO\nto\tO\nbe\tO\nneurotoxic\tB-Disease\nin\tO\nanimals\tO\nand\tO\nhumans\tO\n,\tO\nbut\tO\nits\tO\nacute\tO\nneurotoxicity\tB-Disease\nremains\tO\npoorly\tO\ncharacterized\tO\nin\tO\nchildren\tO\n.\tO\n\nWe\tO\nreport\tO\nhere\tO\na\tO\nretrospective\tO\nstudy\tO\nof\tO\n123\tO\nchildren\tO\n(\tO\nmedian\tO\nage\tO\n,\tO\n6\tO\n.\tO\n5\tO\nyears\tO\n)\tO\nreceiving\tO\nhigh\tO\n-\tO\ndose\tO\nbusulfan\tB-Chemical\nin\tO\ncombined\tO\nchemotherapy\tO\nbefore\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\nfor\tO\nmalignant\tO\nsolid\tO\ntumors\tB-Disease\n,\tO\nbrain\tB-Disease\ntumors\tI-Disease\nexcluded\tO\n.\tO\n\nBusulfan\tB-Chemical\nwas\tO\ngiven\tO\np\tO\n.\tO\no\tO\n.\tO\n,\tO\nevery\tO\n6\tO\nhours\tO\nfor\tO\n16\tO\ndoses\tO\nover\tO\n4\tO\ndays\tO\n.\tO\n\nTwo\tO\ntotal\tO\ndoses\tO\nwere\tO\nconsecutively\tO\nused\tO\n:\tO\n16\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nthen\tO\n600\tO\nmg\tO\n/\tO\nm2\tO\n.\tO\n\nThe\tO\ndose\tO\ncalculation\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\nbody\tO\nsurface\tO\narea\tO\nresults\tO\nin\tO\nhigher\tO\ndoses\tO\nin\tO\nyoung\tO\nchildren\tO\nthan\tO\nin\tO\nolder\tO\npatients\tO\n(\tO\n16\tO\nto\tO\n28\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nNinety\tO\n-\tO\nsix\tO\npatients\tO\nwere\tO\nnot\tO\ngiven\tO\nanticonvulsive\tO\nprophylaxis\tO\n;\tO\n7\tO\n(\tO\n7\tO\n.\tO\n5\tO\n%\tO\n)\tO\ndeveloped\tO\nseizures\tB-Disease\nduring\tO\nthe\tO\n4\tO\ndays\tO\nof\tO\nthe\tO\nbusulfan\tB-Chemical\ncourse\tO\nor\tO\nwithin\tO\n24\tO\nh\tO\nafter\tO\nthe\tO\nlast\tO\ndosing\tO\n.\tO\n\nWhen\tO\nthe\tO\ntotal\tO\nbusulfan\tB-Chemical\ndose\tO\nwas\tO\ntaken\tO\ninto\tO\naccount\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nsignificant\tO\ndifference\tO\nin\tO\nterms\tO\nof\tO\nneurotoxicity\tB-Disease\nincidence\tO\namong\tO\npatients\tO\nunder\tO\n16\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\n1\tO\nof\tO\n57\tO\n,\tO\n1\tO\n.\tO\n7\tO\n%\tO\n)\tO\nand\tO\npatients\tO\nunder\tO\n600\tO\nmg\tO\n/\tO\nm2\tO\n(\tO\n6\tO\nof\tO\n39\tO\n,\tO\n15\tO\n.\tO\n4\tO\n%\tO\n)\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nTwenty\tO\n-\tO\nseven\tO\npatients\tO\nwere\tO\ngiven\tO\na\tO\n600\tO\n-\tO\nmg\tO\n/\tO\nm2\tO\nbusulfan\tB-Chemical\ntotal\tO\ndose\tO\nwith\tO\ncontinuous\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusion\tO\nof\tO\nclonazepam\tB-Chemical\n;\tO\nnone\tO\nhad\tO\nany\tO\nneurological\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nBusulfan\tB-Chemical\nlevels\tO\nwere\tO\nmeasured\tO\nby\tO\na\tO\ngas\tO\nchromatographic\tO\n-\tO\nmass\tO\nspectrometry\tO\nassay\tO\nin\tO\nthe\tO\nplasma\tO\nand\tO\ncerebrospinal\tO\nfluid\tO\nof\tO\n9\tO\nchildren\tO\nwithout\tO\ncentral\tB-Disease\nnervous\tI-Disease\nsystem\tI-Disease\ndisease\tI-Disease\nunder\tO\n600\tO\nmg\tO\n/\tO\nm2\tO\nbusulfan\tB-Chemical\nwith\tO\nclonazepam\tB-Chemical\n:\tO\nbusulfan\tB-Chemical\ncerebrospinal\tO\nfluid\tO\n:\tO\nplasma\tO\nratio\tO\nwas\tO\n1\tO\n.\tO\n39\tO\n.\tO\n\nThis\tO\nwas\tO\nsignificantly\tO\ndifferent\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n02\tO\n)\tO\nfrom\tO\nthe\tO\ncerebrospinal\tO\nfluid\tO\n:\tO\nplasma\tO\nratio\tO\npreviously\tO\ndefined\tO\nin\tO\nchildren\tO\nreceiving\tO\na\tO\n16\tO\n-\tO\nmg\tO\n/\tO\nkg\tO\ntotal\tO\ndose\tO\nof\tO\nbusulfan\tB-Chemical\n.\tO\n\nThis\tO\nstudy\tO\nshows\tO\nthat\tO\nbusulfan\tB-Chemical\nneurotoxicity\tB-Disease\nis\tO\ndose\tO\n-\tO\ndependent\tO\nin\tO\nchildren\tO\nand\tO\nefficiently\tO\nprevented\tO\nby\tO\nclonazepam\tB-Chemical\n.\tO\n\nA\tO\nbusulfan\tB-Chemical\ndose\tO\ncalculated\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\nbody\tO\nsurface\tO\narea\tO\n,\tO\nresulting\tO\nin\tO\nhigher\tO\ndoses\tO\nin\tO\nyoung\tO\nchildren\tO\n,\tO\nwas\tO\nfollowed\tO\nby\tO\nincreased\tO\nneurotoxicity\tB-Disease\n,\tO\nclose\tO\nto\tO\nneurotoxicity\tB-Disease\nincidence\tO\nobserved\tO\nin\tO\nadults\tO\n.\tO\n\nSince\tO\nplasma\tO\npharmacokinetic\tO\nstudies\tO\nshowed\tO\na\tO\nfaster\tO\nbusulfan\tB-Chemical\nclearance\tO\nin\tO\nchildren\tO\nthan\tO\nin\tO\nadults\tO\n,\tO\nthis\tO\nnew\tO\ndose\tO\nmay\tO\napproximate\tO\nmore\tO\nclosely\tO\nthe\tO\nadult\tO\nsystemic\tO\nexposure\tO\nobtained\tO\nafter\tO\nthe\tO\nusual\tO\n16\tO\n-\tO\nmg\tO\n/\tO\nkg\tO\ntotal\tO\ndose\tO\n,\tO\nwith\tO\npotential\tO\ninferences\tO\nin\tO\nterms\tO\nof\tO\nanticancer\tO\nor\tO\nmyeloablative\tO\neffects\tO\n.\tO\n\nThe\tO\nbusulfan\tB-Chemical\ndose\tO\nin\tO\nchildren\tO\nand\tO\ninfants\tO\nundergoing\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\nshould\tO\nbe\tO\nreconsidered\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\npharmacokinetic\tO\nstudies\tO\n.\tO\n\nAn\tO\nunexpected\tO\ndiagnosis\tO\nin\tO\na\tO\nrenal\tO\n-\tO\ntransplant\tO\npatient\tO\nwith\tO\nproteinuria\tB-Disease\ntreated\tO\nwith\tO\neverolimus\tB-Chemical\n:\tO\nAL\tB-Disease\namyloidosis\tB-Disease\n.\tO\n\nProteinuria\tB-Disease\nis\tO\nan\tO\nexpected\tO\ncomplication\tO\nin\tO\ntransplant\tO\npatients\tO\ntreated\tO\nwith\tO\nmammalian\tO\ntarget\tO\nof\tO\nrapamycin\tB-Chemical\ninhibitors\tO\n(\tO\nmTOR\tO\n-\tO\ni\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nclinical\tO\nsuspicion\tO\nshould\tO\nalways\tO\nbe\tO\nsupported\tO\nby\tO\nhistological\tO\nevidence\tO\nin\tO\norder\tO\nto\tO\ninvestigate\tO\npotential\tO\nalternate\tO\ndiagnoses\tO\nsuch\tO\nas\tO\nacute\tO\nor\tO\nchronic\tO\nrejection\tO\n,\tO\ninterstitial\tO\nfibrosis\tB-Disease\nand\tO\ntubular\tO\natrophy\tB-Disease\n,\tO\nor\tO\nrecurrent\tO\nor\tO\nde\tO\nnovo\tO\nglomerulopathy\tB-Disease\n.\tO\n\nIn\tO\nthis\tO\ncase\tO\nwe\tO\nreport\tO\nthe\tO\nunexpected\tO\ndiagnosis\tO\nof\tO\namyloidosis\tB-Disease\nin\tO\na\tO\nrenal\tO\n-\tO\ntransplant\tO\npatient\tO\nwith\tO\npre\tO\n-\tO\ntransplant\tO\nmonoclonal\tO\ngammapathy\tO\nof\tO\nundetermined\tO\nsignificance\tO\nwho\tO\ndeveloped\tO\nproteinuria\tB-Disease\nafter\tO\nconversion\tO\nfrom\tO\ntacrolimus\tB-Chemical\nto\tO\neverolimus\tB-Chemical\n.\tO\n\nLong\tO\n-\tO\nterm\tO\noral\tO\ngalactose\tB-Chemical\ntreatment\tO\nprevents\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\nin\tO\nmale\tO\nWistar\tO\nrats\tO\ntreated\tO\nintracerebroventricularly\tO\nwith\tO\nstreptozotocin\tB-Chemical\n.\tO\n\nBasic\tO\nand\tO\nclinical\tO\nresearch\tO\nhas\tO\ndemonstrated\tO\nthat\tO\ndementia\tB-Disease\nof\tO\nsporadic\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nsAD\tO\n)\tO\ntype\tO\nis\tO\nassociated\tO\nwith\tO\ndysfunction\tO\nof\tO\nthe\tO\ninsulin\tO\n-\tO\nreceptor\tO\n(\tO\nIR\tO\n)\tO\nsystem\tO\nfollowed\tO\nby\tO\ndecreased\tO\nglucose\tB-Chemical\ntransport\tO\nvia\tO\nglucose\tB-Chemical\ntransporter\tO\nGLUT4\tO\nand\tO\ndecreased\tO\nglucose\tB-Chemical\nmetabolism\tO\nin\tO\nbrain\tO\ncells\tO\n.\tO\n\nAn\tO\nalternative\tO\nsource\tO\nof\tO\nenergy\tO\nis\tO\nd\tB-Chemical\n-\tI-Chemical\ngalactose\tI-Chemical\n(\tO\nthe\tO\nC\tO\n-\tO\n4\tO\n-\tO\nepimer\tO\nof\tO\nd\tB-Chemical\n-\tI-Chemical\nglucose\tI-Chemical\n)\tO\nwhich\tO\nis\tO\ntransported\tO\ninto\tO\nthe\tO\nbrain\tO\nby\tO\ninsulin\tO\n-\tO\nindependent\tO\nGLUT3\tO\ntransporter\tO\nwhere\tO\nit\tO\nmight\tO\nbe\tO\nmetabolized\tO\nto\tO\nglucose\tB-Chemical\nvia\tO\nthe\tO\nLeloir\tO\npathway\tO\n.\tO\n\nExclusively\tO\nparenteral\tO\ndaily\tO\ninjections\tO\nof\tO\ngalactose\tB-Chemical\ninduce\tO\nmemory\tB-Disease\ndeterioration\tI-Disease\nin\tO\nrodents\tO\nand\tO\nare\tO\nused\tO\nto\tO\ngenerate\tO\nanimal\tO\naging\tO\nmodel\tO\n,\tO\nbut\tO\nthe\tO\neffects\tO\nof\tO\noral\tO\ngalactose\tB-Chemical\ntreatment\tO\non\tO\ncognitive\tO\nfunctions\tO\nhave\tO\nnever\tO\nbeen\tO\ntested\tO\n.\tO\n\nWe\tO\nhave\tO\ninvestigated\tO\nthe\tO\neffects\tO\nof\tO\ncontinuous\tO\ndaily\tO\noral\tO\ngalactose\tB-Chemical\n(\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n)\tO\ntreatment\tO\non\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\nin\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\n(\tO\nSTZ\tB-Chemical\n-\tO\nicv\tO\n)\tO\nrat\tO\nmodel\tO\nof\tO\nsAD\tO\n,\tO\ntested\tO\nby\tO\nMorris\tO\nWater\tO\nMaze\tO\nand\tO\nPassive\tO\nAvoidance\tO\ntest\tO\n,\tO\nrespectively\tO\n.\tO\n\nOne\tO\nmonth\tO\nof\tO\noral\tO\ngalactose\tB-Chemical\ntreatment\tO\ninitiated\tO\nimmediately\tO\nafter\tO\nthe\tO\nSTZ\tB-Chemical\n-\tO\nicv\tO\nadministration\tO\n,\tO\nsuccessfully\tO\nprevented\tO\ndevelopment\tO\nof\tO\nthe\tO\nSTZ\tB-Chemical\n-\tO\nicv\tO\n-\tO\ninduced\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\n.\tO\n\nBeneficial\tO\neffect\tO\nof\tO\noral\tO\ngalactose\tB-Chemical\nwas\tO\nindependent\tO\nof\tO\nthe\tO\nrat\tO\nage\tO\nand\tO\nof\tO\nthe\tO\ngalactose\tB-Chemical\ndose\tO\nranging\tO\nfrom\tO\n100\tO\nto\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n.\tO\n\nAdditionally\tO\n,\tO\noral\tO\ngalactose\tB-Chemical\nadministration\tO\nled\tO\nto\tO\nthe\tO\nappearance\tO\nof\tO\ngalactose\tB-Chemical\nin\tO\nthe\tO\nblood\tO\n.\tO\n\nThe\tO\nincrease\tO\nof\tO\ngalactose\tB-Chemical\nconcentration\tO\nin\tO\nthe\tO\ncerebrospinal\tO\nfluid\tO\nwas\tO\nseveral\tO\ntimes\tO\nlower\tO\nafter\tO\noral\tO\nthan\tO\nafter\tO\nparenteral\tO\nadministration\tO\nof\tO\nthe\tO\nsame\tO\ngalactose\tB-Chemical\ndose\tO\n.\tO\n\nOral\tO\ngalactose\tB-Chemical\nexposure\tO\nmight\tO\nhave\tO\nbeneficial\tO\neffects\tO\non\tO\nlearning\tO\nand\tO\nmemory\tO\nability\tO\nand\tO\ncould\tO\nbe\tO\nworth\tO\ninvestigating\tO\nfor\tO\nimprovement\tO\nof\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\nassociated\tO\nwith\tO\nglucose\tB-Disease\nhypometabolism\tI-Disease\nin\tO\nAD\tB-Disease\n.\tO\n\nAn\tO\ninvestigation\tO\nof\tO\nthe\tO\npattern\tO\nof\tO\nkidney\tB-Disease\ninjury\tI-Disease\nin\tO\nHIV\tO\n-\tO\npositive\tO\npersons\tO\nexposed\tO\nto\tO\ntenofovir\tB-Chemical\ndisoproxil\tI-Chemical\nfumarate\tI-Chemical\n:\tO\nan\tO\nexamination\tO\nof\tO\na\tO\nlarge\tO\npopulation\tO\ndatabase\tO\n(\tO\nMHRA\tO\ndatabase\tO\n)\tO\n.\tO\n\nThe\tO\npotential\tO\nfor\tO\ntenofovir\tB-Chemical\nto\tO\ncause\tO\na\tO\nrange\tO\nof\tO\nkidney\tO\nsyndromes\tO\nhas\tO\nbeen\tO\nestablished\tO\nfrom\tO\nmechanistic\tO\nand\tO\nrandomised\tO\nclinical\tO\ntrials\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nexact\tO\npattern\tO\nof\tO\nkidney\tO\ninvolvement\tO\nis\tO\nstill\tO\nuncertain\tO\n.\tO\n\nWe\tO\nundertook\tO\na\tO\ndescriptive\tO\nanalysis\tO\nof\tO\nYellow\tO\nCard\tO\nrecords\tO\nof\tO\n407\tO\nHIV\tO\n-\tO\npositive\tO\npersons\tO\ntaking\tO\ntenofovir\tB-Chemical\ndisoproxil\tI-Chemical\nfumarate\tI-Chemical\n(\tO\nTDF\tB-Chemical\n)\tO\nas\tO\npart\tO\nof\tO\ntheir\tO\nantiretroviral\tO\ntherapy\tO\nregimen\tO\nand\tO\nsubmitted\tO\nto\tO\nthe\tO\nMedicines\tO\nand\tO\nHealthcare\tO\nProducts\tO\nRegulatory\tO\nAgency\tO\n(\tO\nMHRA\tO\n)\tO\nwith\tO\nsuspected\tO\nkidney\tO\nadverse\tO\neffects\tO\n.\tO\n\nReports\tO\nthat\tO\nsatisfy\tO\ndefined\tO\ncriteria\tO\nwere\tO\nclassified\tO\nas\tO\nacute\tB-Disease\nkidney\tI-Disease\ninjury\tI-Disease\n,\tO\nkidney\tB-Disease\ntubular\tI-Disease\ndysfunction\tI-Disease\nand\tO\nFanconi\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nOf\tO\nthe\tO\n407\tO\nYellow\tO\nCard\tO\nrecords\tO\nanalysed\tO\n,\tO\n106\tO\nsatisfied\tO\ncriteria\tO\nfor\tO\nTDF\tB-Chemical\n-\tO\nrelated\tO\nkidney\tB-Disease\ndisease\tI-Disease\n,\tO\nof\tO\nwhich\tO\n53\tO\n(\tO\n50\tO\n%\tO\n)\tO\nhad\tO\nfeatures\tO\nof\tO\nkidney\tB-Disease\ntubular\tI-Disease\ndysfunction\tI-Disease\n,\tO\n35\tO\n(\tO\n33\tO\n%\tO\n)\tO\nwere\tO\nfound\tO\nto\tO\nhave\tO\nfeatures\tO\nof\tO\nglomerular\tB-Disease\ndysfunction\tI-Disease\nand\tO\n18\tO\n(\tO\n17\tO\n%\tO\n)\tO\nhad\tO\nFanconi\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\nmedian\tO\nTDF\tB-Chemical\nexposure\tO\nwas\tO\n316\tO\ndays\tO\n(\tO\ninterquartile\tO\nrange\tO\n120\tO\n-\tO\n740\tO\n)\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nhospitalisation\tO\nfor\tO\nTDF\tB-Chemical\nkidney\tO\nadverse\tO\neffects\tO\nwas\tO\nhigh\tO\n,\tO\nparticularly\tO\namongst\tO\npatients\tO\nwith\tO\nfeatures\tO\nof\tO\nFanconi\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\npattern\tO\nof\tO\nkidney\tO\nsyndromes\tO\nin\tO\nthis\tO\npopulation\tO\nseries\tO\nmirrors\tO\nthat\tO\nreported\tO\nin\tO\nrandomised\tO\nclinical\tO\ntrials\tO\n.\tO\n\nCessation\tO\nof\tO\nTDF\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\ncomplete\tO\nrestoration\tO\nof\tO\nkidney\tO\nfunction\tO\nin\tO\nup\tO\nhalf\tO\nof\tO\nthe\tO\npatients\tO\nin\tO\nthis\tO\nreport\tO\n.\tO\n\nIncidence\tO\nof\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\nis\tO\nhigh\tO\neven\tO\nin\tO\na\tO\npopulation\tO\nwithout\tO\nknown\tO\nrisk\tO\nfactors\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nPostoperative\tB-Disease\ndelirium\tI-Disease\nis\tO\na\tO\nrecognized\tO\ncomplication\tO\nin\tO\npopulations\tO\nat\tO\nrisk\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nis\tO\nto\tO\nassess\tO\nthe\tO\nprevalence\tO\nof\tO\nearly\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\nin\tO\na\tO\npopulation\tO\nwithout\tO\nknown\tO\nrisk\tO\nfactors\tO\nadmitted\tO\nto\tO\nthe\tO\nICU\tO\nfor\tO\npostoperative\tO\nmonitoring\tO\nafter\tO\nelective\tO\nmajor\tO\nsurgery\tO\n.\tO\n\nThe\tO\nsecondary\tO\noutcome\tO\ninvestigated\tO\nis\tO\nto\tO\nidentify\tO\neventual\tO\nindependent\tO\nrisk\tO\nfactors\tO\namong\tO\ndemographic\tO\ndata\tO\nand\tO\nanesthetic\tO\ndrugs\tO\nused\tO\n.\tO\n\nMETHODS\tO\n:\tO\nAn\tO\nobservational\tO\n,\tO\nprospective\tO\nstudy\tO\nwas\tO\nconducted\tO\non\tO\na\tO\nconsecutive\tO\ncohort\tO\nof\tO\npatients\tO\nadmitted\tO\nto\tO\nour\tO\nICU\tO\nwithin\tO\nand\tO\nfor\tO\nat\tO\nleast\tO\n24\tO\nh\tO\nafter\tO\nmajor\tO\nsurgical\tO\nprocedures\tO\n.\tO\n\nExclusion\tO\ncriteria\tO\nwere\tO\nany\tO\npreexisting\tO\npredisposing\tO\nfactor\tO\nfor\tO\ndelirium\tB-Disease\nor\tO\nother\tO\npotentially\tO\nconfounding\tO\nneurological\tB-Disease\ndysfunctions\tI-Disease\n.\tO\n\nPatients\tO\nwere\tO\nassessed\tO\ndaily\tO\nusing\tO\nthe\tO\nconfusion\tB-Disease\nassessment\tO\nmethod\tO\nfor\tO\nthe\tO\nICU\tO\nscale\tO\nfor\tO\n3\tO\ndays\tO\nafter\tO\nthe\tO\nsurgical\tO\nprocedure\tO\n.\tO\n\nEarly\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\nincidence\tO\nrisk\tO\nfactors\tO\nwere\tO\nthen\tO\nassessed\tO\nthrough\tO\nthree\tO\ndifferent\tO\nmultiple\tO\nregression\tO\nmodels\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAccording\tO\nto\tO\nthe\tO\nconfusion\tO\nassessment\tO\nmethod\tO\nfor\tO\nthe\tO\nICU\tO\nscale\tO\n,\tO\n28\tO\n%\tO\nof\tO\npatients\tO\nwere\tO\ndiagnosed\tO\nwith\tO\nearly\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\n.\tO\n\nThe\tO\nuse\tO\nof\tO\nthiopentone\tB-Chemical\nwas\tO\nsignificantly\tO\nassociated\tO\nwith\tO\nan\tO\neight\tO\n-\tO\nfold\tO\n-\tO\nhigher\tO\nrisk\tO\nfor\tO\ndelirium\tB-Disease\ncompared\tO\nto\tO\npropofol\tB-Chemical\n(\tO\n57\tO\n.\tO\n1\tO\n%\tO\nvs\tO\n.\tO\n7\tO\n.\tO\n1\tO\n%\tO\n,\tO\nRR\tO\n=\tO\n8\tO\n.\tO\n0\tO\n,\tO\nX2\tO\n=\tO\n4\tO\n.\tO\n256\tO\n;\tO\ndf\tO\n=\tO\n1\tO\n;\tO\n0\tO\n.\tO\n05\tO\n<\tO\np\tO\n<\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\nthis\tO\nstudy\tO\nearly\tO\npostoperative\tB-Disease\ndelirium\tI-Disease\nwas\tO\nfound\tO\nto\tO\nbe\tO\na\tO\nvery\tO\ncommon\tO\ncomplication\tO\nafter\tO\nmajor\tO\nsurgery\tO\n,\tO\neven\tO\nin\tO\na\tO\npopulation\tO\nwithout\tO\nknown\tO\nrisk\tO\nfactors\tO\n.\tO\n\nThiopentone\tB-Chemical\nwas\tO\nindependently\tO\nassociated\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nits\tO\nrelative\tO\nrisk\tO\n.\tO\n\nA\tO\nsingle\tO\nneurotoxic\tB-Disease\ndose\tO\nof\tO\nmethamphetamine\tB-Chemical\ninduces\tO\na\tO\nlong\tO\n-\tO\nlasting\tO\ndepressive\tB-Disease\n-\tO\nlike\tO\nbehaviour\tO\nin\tO\nmice\tO\n.\tO\n\nMethamphetamine\tB-Chemical\n(\tO\nMETH\tB-Chemical\n)\tO\ntriggers\tO\na\tO\ndisruption\tO\nof\tO\nthe\tO\nmonoaminergic\tO\nsystem\tO\nand\tO\nMETH\tB-Chemical\nabuse\tO\nleads\tO\nto\tO\nnegative\tO\nemotional\tO\nstates\tO\nincluding\tO\ndepressive\tB-Disease\nsymptoms\tI-Disease\nduring\tO\ndrug\tO\nwithdrawal\tO\n.\tO\n\nHowever\tO\n,\tO\nit\tO\nis\tO\ncurrently\tO\nunknown\tO\nif\tO\nthe\tO\nacute\tO\ntoxic\tO\ndosage\tO\nof\tO\nMETH\tB-Chemical\nalso\tO\ncauses\tO\na\tO\nlong\tO\n-\tO\nlasting\tO\ndepressive\tB-Disease\nphenotype\tO\nand\tO\npersistent\tO\nmonoaminergic\tO\ndeficits\tO\n.\tO\n\nThus\tO\n,\tO\nwe\tO\nnow\tO\nassessed\tO\nthe\tO\ndepressive\tB-Disease\n-\tO\nlike\tO\nbehaviour\tO\nin\tO\nmice\tO\nat\tO\nearly\tO\nand\tO\nlong\tO\n-\tO\nterm\tO\nperiods\tO\nfollowing\tO\na\tO\nsingle\tO\nhigh\tO\nMETH\tB-Chemical\ndose\tO\n(\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nMETH\tB-Chemical\ndid\tO\nnot\tO\nalter\tO\nthe\tO\nmotor\tO\nfunction\tO\nand\tO\nprocedural\tO\nmemory\tO\nof\tO\nmice\tO\nas\tO\nassessed\tO\nby\tO\nswimming\tO\nspeed\tO\nand\tO\nescape\tO\nlatency\tO\nto\tO\nfind\tO\nthe\tO\nplatform\tO\nin\tO\na\tO\ncued\tO\nversion\tO\nof\tO\nthe\tO\nwater\tO\nmaze\tO\ntask\tO\n.\tO\n\nHowever\tO\n,\tO\nMETH\tB-Chemical\nsignificantly\tO\nincreased\tO\nthe\tO\nimmobility\tO\ntime\tO\nin\tO\nthe\tO\ntail\tO\nsuspension\tO\ntest\tO\nat\tO\n3\tO\nand\tO\n49\tO\ndays\tO\npost\tO\n-\tO\nadministration\tO\n.\tO\n\nThis\tO\ndepressive\tB-Disease\n-\tO\nlike\tO\nprofile\tO\ninduced\tO\nby\tO\nMETH\tB-Chemical\nwas\tO\naccompanied\tO\nby\tO\na\tO\nmarked\tO\ndepletion\tO\nof\tO\nfrontostriatal\tO\ndopaminergic\tO\nand\tO\nserotonergic\tO\nneurotransmission\tO\n,\tO\nindicated\tO\nby\tO\na\tO\nreduction\tO\nin\tO\nthe\tO\nlevels\tO\nof\tO\ndopamine\tB-Chemical\n,\tO\nDOPAC\tB-Chemical\nand\tO\nHVA\tB-Chemical\n,\tO\ntyrosine\tB-Chemical\nhydroxylase\tO\nand\tO\nserotonin\tB-Chemical\n,\tO\nobserved\tO\nat\tO\nboth\tO\n3\tO\nand\tO\n49\tO\ndays\tO\npost\tO\n-\tO\nadministration\tO\n.\tO\n\nIn\tO\nparallel\tO\n,\tO\nanother\tO\nneurochemical\tO\nfeature\tO\nof\tO\ndepression\tB-Disease\n-\tO\n-\tO\nastroglial\tO\ndysfunction\tO\n-\tO\n-\tO\nwas\tO\nunaffected\tO\nin\tO\nthe\tO\ncortex\tO\nand\tO\nthe\tO\nstriatal\tO\nlevels\tO\nof\tO\nthe\tO\nastrocytic\tO\nprotein\tO\nmarker\tO\n,\tO\nglial\tO\nfibrillary\tO\nacidic\tO\nprotein\tO\n,\tO\nwere\tO\nonly\tO\ntransiently\tO\nincreased\tO\nat\tO\n3\tO\ndays\tO\n.\tO\n\nThese\tO\nfindings\tO\ndemonstrate\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nthat\tO\na\tO\nsingle\tO\nhigh\tO\ndose\tO\nof\tO\nMETH\tB-Chemical\ninduces\tO\nlong\tO\n-\tO\nlasting\tO\ndepressive\tB-Disease\n-\tO\nlike\tO\nbehaviour\tO\nin\tO\nmice\tO\nassociated\tO\nwith\tO\na\tO\npersistent\tO\ndisruption\tO\nof\tO\nfrontostriatal\tO\ndopaminergic\tO\nand\tO\nserotonergic\tO\nhomoeostasis\tO\n.\tO\n\nLinezolid\tB-Chemical\n-\tO\ninduced\tO\noptic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nMany\tO\nsystemic\tO\nantimicrobials\tO\nhave\tO\nbeen\tO\nimplicated\tO\nto\tO\ncause\tO\nocular\tO\nadverse\tO\neffects\tO\n.\tO\n\nThis\tO\nis\tO\nespecially\tO\nrelevant\tO\nin\tO\nmultidrug\tO\ntherapy\tO\nwhere\tO\nmore\tO\nthan\tO\none\tO\ndrug\tO\ncan\tO\ncause\tO\na\tO\nsimilar\tO\nocular\tO\nadverse\tO\neffect\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\nprogressive\tO\nloss\tB-Disease\nof\tI-Disease\nvision\tI-Disease\nassociated\tO\nwith\tO\nlinezolid\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\n45\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\npatient\tO\nwho\tO\nwas\tO\non\tO\ntreatment\tO\nwith\tO\nmultiple\tO\nsecond\tO\n-\tO\nline\tO\nanti\tO\n-\tO\ntuberculous\tO\ndrugs\tO\nincluding\tO\nlinezolid\tB-Chemical\nand\tO\nethambutol\tB-Chemical\nfor\tO\nextensively\tB-Disease\ndrug\tI-Disease\n-\tI-Disease\nresistant\tI-Disease\ntuberculosis\tI-Disease\n(\tO\nXDR\tB-Disease\n-\tI-Disease\nTB\tI-Disease\n)\tO\npresented\tO\nto\tO\nus\tO\nwith\tO\npainless\tO\nprogressive\tO\nloss\tB-Disease\nof\tI-Disease\nvision\tI-Disease\nin\tO\nboth\tO\neyes\tO\n.\tO\n\nColor\tO\nvision\tO\nwas\tO\ndefective\tO\nand\tO\nfundus\tO\nexamination\tO\nrevealed\tO\noptic\tB-Disease\ndisc\tI-Disease\nedema\tI-Disease\nin\tO\nboth\tO\neyes\tO\n.\tO\n\nEthambutol\tB-Chemical\n-\tO\ninduced\tO\ntoxic\tB-Disease\noptic\tI-Disease\nneuropathy\tI-Disease\nwas\tO\nsuspected\tO\nand\tO\ntablet\tO\nethambutol\tB-Chemical\nwas\tO\nwithdrawn\tO\n.\tO\n\nDeterioration\tB-Disease\nof\tI-Disease\nvision\tI-Disease\noccurred\tO\ndespite\tO\nwithdrawal\tO\nof\tO\nethambutol\tB-Chemical\n.\tO\n\nDiscontinuation\tO\nof\tO\nlinezolid\tB-Chemical\nresulted\tO\nin\tO\nmarked\tO\nimprovement\tO\nof\tO\nvision\tO\n.\tO\n\nOur\tO\nreport\tO\nemphasizes\tO\nthe\tO\nneed\tO\nfor\tO\nmonitoring\tO\nof\tO\nvisual\tO\nfunction\tO\nin\tO\npatients\tO\non\tO\nlong\tO\n-\tO\nterm\tO\nlinezolid\tB-Chemical\ntreatment\tO\n.\tO\n\nResuscitation\tO\nwith\tO\nlipid\tO\n,\tO\nepinephrine\tB-Chemical\n,\tO\nor\tO\nboth\tO\nin\tO\nlevobupivacaine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nin\tO\nnewborn\tO\npiglets\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\noptimal\tO\ndosing\tO\nregimens\tO\nof\tO\nlipid\tO\nemulsion\tO\n,\tO\nepinephrine\tB-Chemical\n,\tO\nor\tO\nboth\tO\nare\tO\nnot\tO\nyet\tO\ndetermined\tO\nin\tO\nneonates\tO\nin\tO\ncases\tO\nof\tO\nlocal\tO\nanaesthetic\tO\nsystemic\tO\ntoxicity\tB-Disease\n(\tO\nLAST\tO\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nNewborn\tO\npiglets\tO\nreceived\tO\nlevobupivacaine\tB-Chemical\nuntil\tO\ncardiovascular\tB-Disease\ncollapse\tI-Disease\noccurred\tO\n.\tO\n\nStandard\tO\ncardiopulmonary\tO\nresuscitation\tO\nwas\tO\nstarted\tO\nand\tO\nelectrocardiogram\tO\n(\tO\nECG\tO\n)\tO\nwas\tO\nmonitored\tO\nfor\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n,\tO\nfibrillation\tB-Disease\n,\tO\nor\tO\nQRS\tO\nprolongation\tO\n.\tO\n\nPiglets\tO\nwere\tO\nthen\tO\nrandomly\tO\nallocated\tO\nto\tO\nfour\tO\ngroups\tO\n:\tO\ncontrol\tO\n(\tO\nsaline\tO\n)\tO\n,\tO\nIntralipid\tO\n(\tO\n)\tO\nalone\tO\n,\tO\nepinephrine\tB-Chemical\nalone\tO\n,\tO\nor\tO\na\tO\ncombination\tO\nof\tO\nIntralipd\tO\nplus\tO\nepinephrine\tB-Chemical\n.\tO\n\nResuscitation\tO\ncontinued\tO\nfor\tO\n30\tO\nmin\tO\nor\tO\nuntil\tO\nthere\tO\nwas\tO\na\tO\nreturn\tO\nof\tO\nspontaneous\tO\ncirculation\tO\n(\tO\nROSC\tO\n)\tO\naccompanied\tO\nby\tO\na\tO\nmean\tO\narterial\tO\npressure\tO\nat\tO\nor\tO\nsuperior\tO\nto\tO\nthe\tO\nbaseline\tO\npressure\tO\nand\tO\nnormal\tO\nsinus\tO\nrhythm\tO\nfor\tO\na\tO\nperiod\tO\nof\tO\n30\tO\nmin\tO\n.\tO\n\nRESULTS\tO\n:\tO\nROSC\tO\nwas\tO\nachieved\tO\nin\tO\nonly\tO\none\tO\nof\tO\nthe\tO\ncontrol\tO\npiglets\tO\ncompared\tO\nwith\tO\nmost\tO\nof\tO\nthe\tO\ntreated\tO\npiglets\tO\n.\tO\n\nMortality\tO\nwas\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\nbetween\tO\nthe\tO\nthree\tO\ntreatment\tO\ngroups\tO\n,\tO\nbut\tO\nwas\tO\nsignificantly\tO\nlower\tO\nin\tO\nall\tO\nthe\tO\ntreatment\tO\ngroups\tO\ncompared\tO\nwith\tO\ncontrol\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\nECG\tO\nabnormalities\tO\nwas\tO\nzero\tO\nin\tO\nthe\tO\nIntralipid\tO\nonly\tO\ngroup\tO\n,\tO\nbut\tO\n14\tO\nand\tO\n17\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nthe\tO\nepinephrine\tB-Chemical\nand\tO\nepinephrine\tB-Chemical\nplus\tO\nlipid\tO\ngroups\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nLipid\tO\nemulsion\tO\nwith\tO\nor\tO\nwithout\tO\nepinephrine\tB-Chemical\n,\tO\nor\tO\nepinephrine\tB-Chemical\nalone\tO\nwere\tO\nequally\tO\neffective\tO\nin\tO\nachieving\tO\na\tO\nreturn\tO\nto\tO\nspontaneous\tO\ncirculation\tO\nin\tO\nthis\tO\nmodel\tO\nof\tO\nLAST\tO\n.\tO\n\nEpinephrine\tB-Chemical\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nlipid\tO\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nnumber\tO\nof\tO\nECG\tO\nabnormalities\tO\ncompared\tO\nwith\tO\nlipid\tO\nemulsion\tO\nalone\tO\n.\tO\n\nIncidence\tO\nof\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\ntype\tI-Disease\nII\tI-Disease\nand\tO\npostoperative\tO\nrecovery\tO\nof\tO\nplatelet\tO\ncount\tO\nin\tO\nliver\tO\ngraft\tO\nrecipients\tO\n:\tO\na\tO\nretrospective\tO\ncohort\tO\nanalysis\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThrombocytopenia\tB-Disease\nin\tO\npatients\tO\nwith\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nliver\tI-Disease\ndisease\tI-Disease\nis\tO\na\tO\ncommon\tO\ndisorder\tO\ncaused\tO\nmainly\tO\nby\tO\nportal\tB-Disease\nhypertension\tI-Disease\n,\tO\nlow\tO\nlevels\tO\nof\tO\nthrombopoetin\tO\n,\tO\nand\tO\nendotoxemia\tB-Disease\n.\tO\n\nThe\tO\nimpact\tO\nof\tO\nimmune\tO\n-\tO\nmediated\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\ntype\tI-Disease\nII\tI-Disease\n(\tO\nHIT\tB-Disease\ntype\tI-Disease\nII\tI-Disease\n)\tO\nas\tO\na\tO\ncause\tO\nof\tO\nthrombocytopenia\tB-Disease\nafter\tO\nliver\tO\ntransplantation\tO\nis\tO\nnot\tO\nyet\tO\nunderstood\tO\n,\tO\nwith\tO\nfew\tO\nliterature\tO\ncitations\tO\nreporting\tO\ncontradictory\tO\nresults\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nour\tO\nstudy\tO\nwas\tO\nto\tO\ndemonstrate\tO\nthe\tO\nperioperative\tO\ncourse\tO\nof\tO\nthrombocytopenia\tB-Disease\nafter\tO\nliver\tO\ntransplantation\tO\nand\tO\ndetermine\tO\nthe\tO\noccurrence\tO\nof\tO\nclinical\tO\nHIT\tB-Disease\ntype\tI-Disease\nII\tI-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nWe\tO\nretrospectively\tO\nevaluated\tO\nthe\tO\nmedical\tO\nrecords\tO\nof\tO\n205\tO\nconsecutive\tO\nadult\tO\npatients\tO\nwho\tO\nunderwent\tO\nfull\tO\n-\tO\nsize\tO\nliver\tO\ntransplantation\tO\nbetween\tO\nJanuary\tO\n2006\tO\nand\tO\nDecember\tO\n2010\tO\ndue\tO\nto\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nor\tI-Disease\nmalignant\tI-Disease\nliver\tI-Disease\ndisease\tI-Disease\n.\tO\n\nPreoperative\tO\nplatelet\tO\ncount\tO\n,\tO\npostoperative\tO\ncourse\tO\nof\tO\nplatelets\tO\n,\tO\nand\tO\nclinical\tO\nsigns\tO\nof\tO\nHIT\tB-Disease\ntype\tI-Disease\nII\tI-Disease\nwere\tO\nanalyzed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n155\tO\n(\tO\n75\tO\n.\tO\n6\tO\n%\tO\n)\tO\nof\tO\n205\tO\npatients\tO\nhad\tO\nthrombocytopenia\tB-Disease\nbefore\tO\ntransplantation\tO\n,\tO\nsignificantly\tO\ninfluenced\tO\nby\tO\nModel\tO\nof\tO\nEnd\tB-Disease\n-\tI-Disease\nStage\tI-Disease\nLiver\tI-Disease\nDisease\tI-Disease\nscore\tO\nand\tO\nliver\tB-Disease\ncirrhosis\tI-Disease\n.\tO\n\nThe\tO\nplatelet\tO\ncount\tO\nexceeded\tO\n100\tO\n,\tO\n000\tO\n/\tO\nuL\tO\nin\tO\nmost\tO\nof\tO\nthe\tO\npatients\tO\n(\tO\nn\tO\n=\tO\n193\tO\n)\tO\nat\tO\na\tO\nmedium\tO\nof\tO\n7\tO\nd\tO\n.\tO\n\nRegarding\tO\nHIT\tB-Disease\nII\tI-Disease\n,\tO\nthere\tO\nwere\tO\nfour\tO\n(\tO\n1\tO\n.\tO\n95\tO\n%\tO\n)\tO\npatients\tO\nwith\tO\na\tO\nbackground\tO\nof\tO\nHIT\tB-Disease\ntype\tI-Disease\nII\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nincidence\tO\nof\tO\nHIT\tB-Disease\nin\tO\npatients\tO\nwith\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\nis\tO\n,\tO\nwith\tO\nabout\tO\n1\tO\n.\tO\n95\tO\n%\tO\n,\tO\nrare\tO\n.\tO\n\nFor\tO\nfurther\tO\nreduction\tO\nof\tO\nHIT\tB-Disease\ntype\tI-Disease\nII\tI-Disease\n,\tO\nthe\tO\nuse\tO\nof\tO\nintravenous\tO\nheparin\tB-Chemical\nshould\tO\nbe\tO\navoided\tO\nand\tO\nthe\tO\nprophylactic\tO\nanticoagulation\tO\nshould\tO\nbe\tO\nperformed\tO\nwith\tO\nlow\tO\n-\tO\nmolecular\tO\n-\tO\nweight\tO\nheparin\tB-Chemical\nafter\tO\nnormalization\tO\nof\tO\nplatelet\tO\ncount\tO\n.\tO\n\nTakotsubo\tB-Disease\nsyndrome\tI-Disease\n(\tO\nor\tO\napical\tB-Disease\nballooning\tI-Disease\nsyndrome\tI-Disease\n)\tO\nsecondary\tO\nto\tO\nZolmitriptan\tB-Chemical\n.\tO\n\nTakotsubo\tB-Disease\nsyndrome\tI-Disease\n(\tO\nTS\tB-Disease\n)\tO\n,\tO\nalso\tO\nknown\tO\nas\tO\nbroken\tB-Disease\nheart\tI-Disease\nsyndrome\tI-Disease\n,\tO\nis\tO\ncharacterized\tO\nby\tO\nleft\tO\nventricle\tO\napical\tO\nballooning\tO\nwith\tO\nelevated\tO\ncardiac\tO\nbiomarkers\tO\nand\tO\nelectrocardiographic\tO\nchanges\tO\nsuggestive\tO\nof\tO\nan\tO\nacute\tB-Disease\ncoronary\tI-Disease\nsyndrome\tI-Disease\n(\tO\nie\tO\n,\tO\nST\tO\n-\tO\nsegment\tO\nelevation\tO\n,\tO\nT\tO\nwave\tO\ninversions\tO\n,\tO\nand\tO\npathologic\tO\nQ\tO\nwaves\tO\n)\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\n54\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nmedical\tO\nhistory\tO\nof\tO\nmitral\tB-Disease\nvalve\tI-Disease\nprolapse\tI-Disease\nand\tO\nmigraines\tB-Disease\n,\tO\nwho\tO\nwas\tO\nadmitted\tO\nto\tO\nthe\tO\nhospital\tO\nfor\tO\nsubsternal\tO\nchest\tB-Disease\npain\tI-Disease\nand\tO\nelectrocardiogram\tO\ndemonstrated\tO\n1\tO\n/\tO\n2\tO\nmm\tO\nST\tO\n-\tO\nsegment\tO\nelevation\tO\nin\tO\nleads\tO\nII\tO\n,\tO\nIII\tO\n,\tO\naVF\tO\n,\tO\nV5\tO\n,\tO\nand\tO\nV6\tO\nand\tO\npositive\tO\ntroponin\tO\nI\tO\n.\tO\n\nEmergent\tO\ncoronary\tO\nangiogram\tO\nrevealed\tO\nnormal\tO\ncoronary\tO\narteries\tO\nwith\tO\nmoderately\tO\nreduced\tO\nleft\tO\nventricular\tO\nejection\tO\nfraction\tO\nwith\tO\nwall\tO\nmotion\tO\nabnormalities\tO\nconsistent\tO\nwith\tO\nTS\tB-Disease\n.\tO\n\nDetailed\tO\nhistory\tO\nobtained\tO\nretrospectively\tO\nrevealed\tO\nthat\tO\nthe\tO\npatient\tO\ntook\tO\nzolmitriptan\tB-Chemical\nsparingly\tO\nonly\tO\nwhen\tO\nshe\tO\nhad\tO\nmigraines\tB-Disease\n.\tO\n\nBut\tO\nbefore\tO\nthis\tO\nevent\tO\n,\tO\nshe\tO\nwas\tO\ntaking\tO\nzolmitriptan\tB-Chemical\n2\tO\n-\tO\n3\tO\ntimes\tO\ndaily\tO\nfor\tO\nseveral\tO\ndays\tO\nbecause\tO\nof\tO\na\tO\npersistent\tO\nmigraine\tB-Disease\nheadache\tI-Disease\n.\tO\n\nShe\tO\notherwise\tO\nreported\tO\nthat\tO\nshe\tO\nis\tO\nquite\tO\nactive\tO\n,\tO\nrides\tO\nhorses\tO\n,\tO\nand\tO\ndoes\tO\nshow\tO\njumping\tO\nwithout\tO\nany\tO\nlimitations\tO\nin\tO\nher\tO\nphysical\tO\nactivity\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nevidence\tO\nof\tO\nany\tO\nrecent\tO\nstress\tO\nor\tO\nstatus\tB-Disease\nmigrainosus\tI-Disease\n.\tO\n\nExtensive\tO\nliterature\tO\nsearch\tO\nrevealed\tO\nmultiple\tO\ncases\tO\nof\tO\ncoronary\tB-Disease\nartery\tI-Disease\nvasospasm\tI-Disease\nsecondary\tO\nto\tO\nzolmitriptan\tB-Chemical\n,\tO\nbut\tO\nnone\tO\nof\tO\nthe\tO\ncases\tO\nwere\tO\nassociated\tO\nwith\tO\nTS\tB-Disease\n.\tO\n\nDepression\tB-Disease\n,\tO\nimpulsiveness\tB-Disease\n,\tO\nsleep\tO\n,\tO\nand\tO\nmemory\tO\nin\tO\npast\tO\nand\tO\npresent\tO\npolydrug\tO\nusers\tO\nof\tO\n3\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethylenedioxymethamphetamine\tI-Chemical\n(\tO\nMDMA\tB-Chemical\n,\tO\necstasy\tB-Chemical\n)\tO\n.\tO\n\nRATIONALE\tO\n:\tO\nEcstasy\tB-Chemical\n(\tO\n3\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethylenedioxymethamphetamine\tI-Chemical\n,\tO\nMDMA\tB-Chemical\n)\tO\nis\tO\na\tO\nworldwide\tO\nrecreational\tO\ndrug\tO\nof\tO\nabuse\tO\n.\tO\n\nUnfortunately\tO\n,\tO\nthe\tO\nresults\tO\nfrom\tO\nhuman\tO\nresearch\tO\ninvestigating\tO\nits\tO\npsychological\tO\neffects\tO\nhave\tO\nbeen\tO\ninconsistent\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\npresent\tO\nstudy\tO\naimed\tO\nto\tO\nbe\tO\nthe\tO\nlargest\tO\nto\tO\ndate\tO\nin\tO\nsample\tO\nsize\tO\nand\tO\n5HT\tO\n-\tO\nrelated\tO\nbehaviors\tO\n;\tO\nthe\tO\nfirst\tO\nto\tO\ncompare\tO\npresent\tO\necstasy\tB-Chemical\nusers\tO\nwith\tO\npast\tO\nusers\tO\nafter\tO\nan\tO\nabstinence\tO\nof\tO\n4\tO\nor\tO\nmore\tO\nyears\tO\n,\tO\nand\tO\nthe\tO\nfirst\tO\nto\tO\ninclude\tO\nrobust\tO\ncontrols\tO\nfor\tO\nother\tO\nrecreational\tO\nsubstances\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nsample\tO\nof\tO\n997\tO\nparticipants\tO\n(\tO\n52\tO\n%\tO\nmale\tO\n)\tO\nwas\tO\nrecruited\tO\nto\tO\nfour\tO\ncontrol\tO\ngroups\tO\n(\tO\nnon\tO\n-\tO\ndrug\tO\n(\tO\nND\tO\n)\tO\n,\tO\nalcohol\tB-Chemical\n/\tO\nnicotine\tB-Chemical\n(\tO\nAN\tB-Chemical\n)\tO\n,\tO\ncannabis\tB-Chemical\n/\tO\nalcohol\tB-Chemical\n/\tO\nnicotine\tB-Chemical\n(\tO\nCAN\tB-Chemical\n)\tO\n,\tO\nnon\tO\n-\tO\necstasy\tB-Chemical\npolydrug\tO\n(\tO\nPD\tO\n)\tO\n)\tO\n,\tO\nand\tO\ntwo\tO\necstasy\tB-Chemical\npolydrug\tO\ngroups\tO\n(\tO\npresent\tO\n(\tO\nMDMA\tB-Chemical\n)\tO\nand\tO\npast\tO\nusers\tO\n(\tO\nEX\tO\n-\tO\nMDMA\tB-Chemical\n)\tO\n.\tO\n\nParticipants\tO\ncompleted\tO\na\tO\ndrug\tO\nhistory\tO\nquestionnaire\tO\n,\tO\nBeck\tO\nDepression\tB-Disease\nInventory\tO\n,\tO\nBarratt\tO\nImpulsiveness\tB-Disease\nScale\tO\n,\tO\nPittsburgh\tO\nSleep\tO\nQuality\tO\nIndex\tO\n,\tO\nand\tO\nWechsler\tO\nMemory\tO\nScale\tO\n-\tO\nRevised\tO\nwhich\tO\n,\tO\nin\tO\ntotal\tO\n,\tO\nprovided\tO\n13\tO\npsychometric\tO\nmeasures\tO\n.\tO\n\nRESULTS\tO\n:\tO\nWhile\tO\nthe\tO\nCAN\tB-Chemical\nand\tO\nPD\tO\ngroups\tO\ntended\tO\nto\tO\nrecord\tO\ngreater\tO\ndeficits\tO\nthan\tO\nthe\tO\nnon\tO\n-\tO\ndrug\tO\ncontrols\tO\n,\tO\nthe\tO\nMDMA\tB-Chemical\nand\tO\nEX\tO\n-\tO\nMDMA\tB-Chemical\ngroups\tO\nrecorded\tO\ngreater\tO\ndeficits\tO\nthan\tO\nall\tO\nthe\tO\ncontrol\tO\ngroups\tO\non\tO\nten\tO\nof\tO\nthe\tO\n13\tO\npsychometric\tO\nmeasures\tO\n.\tO\n\nStrikingly\tO\n,\tO\ndespite\tO\nprolonged\tO\nabstinence\tO\n(\tO\nmean\tO\n,\tO\n4\tO\n.\tO\n98\tO\n;\tO\nrange\tO\n,\tO\n4\tO\n-\tO\n9\tO\nyears\tO\n)\tO\n,\tO\npast\tO\necstasy\tB-Chemical\nusers\tO\nshowed\tO\nfew\tO\nsigns\tO\nof\tO\nrecovery\tO\n.\tO\n\nCompared\tO\nwith\tO\npresent\tO\necstasy\tB-Chemical\nusers\tO\n,\tO\nthe\tO\npast\tO\nusers\tO\nshowed\tO\nno\tO\nchange\tO\nfor\tO\nten\tO\nmeasures\tO\n,\tO\nincreased\tO\nimpairment\tO\nfor\tO\ntwo\tO\nmeasures\tO\n,\tO\nand\tO\nimprovement\tO\non\tO\njust\tO\none\tO\nmeasure\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nGiven\tO\nthis\tO\nrecord\tO\nof\tO\nimpaired\tB-Disease\nmemory\tI-Disease\nand\tO\nclinically\tO\nsignificant\tO\nlevels\tO\nof\tO\ndepression\tB-Disease\n,\tO\nimpulsiveness\tB-Disease\n,\tO\nand\tO\nsleep\tB-Disease\ndisturbance\tI-Disease\n,\tO\nthe\tO\nprognosis\tO\nfor\tO\nthe\tO\ncurrent\tO\ngeneration\tO\nof\tO\necstasy\tB-Chemical\nusers\tO\nis\tO\na\tO\nmajor\tO\ncause\tO\nfor\tO\nconcern\tO\n.\tO\n\nAssociation\tO\nof\tO\ncommon\tO\ngenetic\tO\nvariants\tO\nof\tO\nHOMER1\tO\ngene\tO\nwith\tO\nlevodopa\tB-Chemical\nadverse\tO\neffects\tO\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\npatients\tO\n.\tO\n\nLevodopa\tB-Chemical\nis\tO\nthe\tO\nmost\tO\neffective\tO\nsymptomatic\tO\ntherapy\tO\nfor\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n,\tO\nbut\tO\nits\tO\nchronic\tO\nuse\tO\ncould\tO\nlead\tO\nto\tO\nchronic\tO\nadverse\tO\noutcomes\tO\n,\tO\nsuch\tO\nas\tO\nmotor\tO\nfluctuations\tO\n,\tO\ndyskinesia\tB-Disease\nand\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\n.\tO\n\nHOMER1\tO\nis\tO\na\tO\nprotein\tO\nwith\tO\npivotal\tO\nfunction\tO\nin\tO\nglutamate\tB-Chemical\ntransmission\tO\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nrelated\tO\nto\tO\nthe\tO\npathogenesis\tO\nof\tO\nthese\tO\ncomplications\tO\n.\tO\n\nThis\tO\nstudy\tO\ninvestigates\tO\nwhether\tO\npolymorphisms\tO\nin\tO\nthe\tO\nHOMER1\tO\ngene\tO\npromoter\tO\nregion\tO\nare\tO\nassociated\tO\nwith\tO\nthe\tO\noccurrence\tO\nof\tO\nthe\tO\nchronic\tO\ncomplications\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n205\tO\npatients\tO\nwith\tO\nidiopathic\tB-Disease\nParkinson\tI-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nwere\tO\ninvestigated\tO\n.\tO\n\nPatients\tO\nwere\tO\ngenotyped\tO\nfor\tO\nrs4704559\tO\n,\tO\nrs10942891\tO\nand\tO\nrs4704560\tO\nby\tO\nallelic\tO\ndiscrimination\tO\nwith\tO\nTaqman\tO\nassays\tO\n.\tO\n\nThe\tO\nrs4704559\tO\nG\tO\nallele\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nlower\tO\nprevalence\tO\nof\tO\ndyskinesia\tB-Disease\n(\tO\nprevalence\tO\nratio\tO\n(\tO\nPR\tO\n)\tO\n=\tO\n0\tO\n.\tO\n615\tO\n,\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n(\tO\nCI\tO\n)\tO\n0\tO\n.\tO\n426\tO\n-\tO\n0\tO\n.\tO\n887\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n009\tO\n)\tO\nand\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\n(\tO\nPR\tO\n=\tO\n0\tO\n.\tO\n515\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n295\tO\n-\tO\n0\tO\n.\tO\n899\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n020\tO\n)\tO\n.\tO\n\nOur\tO\ndata\tO\nsuggest\tO\nthat\tO\nHOMER1\tO\nrs4704559\tO\nG\tO\nallele\tO\nhas\tO\na\tO\nprotective\tO\nrole\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nlevodopa\tB-Chemical\nadverse\tO\neffects\tO\n.\tO\n\nCrocin\tB-Chemical\nimproves\tO\nlipid\tO\ndysregulation\tO\nin\tO\nsubacute\tO\ndiazinon\tB-Chemical\nexposure\tO\nthrough\tO\nERK1\tO\n/\tO\n2\tO\npathway\tO\nin\tO\nrat\tO\nliver\tO\n.\tO\n\nINTRODUCTION\tO\n:\tO\nDiazinon\tB-Chemical\nYis\tO\none\tO\nof\tO\nthe\tO\nmost\tO\nbroadly\tO\nused\tO\norganophosphorus\tB-Chemical\ninsecticides\tO\nin\tO\nagriculture\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nshown\tO\nthat\tO\nexposure\tO\nto\tO\ndiazinon\tB-Chemical\nmay\tO\ninterfere\tO\nwith\tO\nlipid\tO\nmetabolism\tO\n.\tO\n\nMoreover\tO\n,\tO\nthe\tO\nhypolipidemic\tO\neffect\tO\nof\tO\ncrocin\tB-Chemical\nhas\tO\nbeen\tO\nestablished\tO\n.\tO\n\nEarlier\tO\nstudies\tO\nrevealed\tO\nthe\tO\nmajor\tO\nrole\tO\nof\tO\nExtracellular\tO\nsignal\tO\n-\tO\nregulated\tO\nkinase\tO\n(\tO\nERK\tO\n)\tO\npathways\tO\nin\tO\nlow\tO\n-\tO\ndensity\tO\nlipoprotein\tO\nreceptor\tO\n(\tO\nLDLr\tO\n)\tO\nexpression\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nevaluate\tO\nchanges\tO\nin\tO\nthe\tO\nregulation\tO\nof\tO\nlipid\tO\nmetabolism\tO\n,\tO\nERK\tO\nand\tO\nLDLr\tO\nexpression\tO\nin\tO\nthe\tO\nliver\tO\nof\tO\nrats\tO\nexposed\tO\nto\tO\nsubacute\tO\ndiazinon\tB-Chemical\n.\tO\n\nFurthermore\tO\nameliorating\tO\neffect\tO\nof\tO\ncrocin\tB-Chemical\non\tO\ndiazinon\tB-Chemical\ninduced\tO\ndisturbed\tO\ncholesterol\tB-Chemical\nhomeostasis\tO\nwas\tO\nstudied\tO\n.\tO\n\nMETHODS\tO\n:\tO\n24\tO\nRats\tO\nwere\tO\ndivided\tO\ninto\tO\n4\tO\ngroups\tO\nand\tO\nreceived\tO\nfollowing\tO\ntreatments\tO\nfor\tO\n4\tO\nweeks\tO\n;\tO\nCorn\tO\noil\tO\n(\tO\ncontrol\tO\n)\tO\n,\tO\ndiazinon\tB-Chemical\n(\tO\n15mg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\n,\tO\norally\tO\n)\tO\nand\tO\ncrocin\tB-Chemical\n(\tO\n12\tO\n.\tO\n5\tO\nand\tO\n25mg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\n,\tO\nintraperitoneally\tO\n)\tO\nin\tO\ncombination\tO\nwith\tO\ndiazinon\tB-Chemical\n(\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nThe\tO\nlevels\tO\nof\tO\ncholesterol\tB-Chemical\n,\tO\ntriglyceride\tB-Chemical\nand\tO\nLDL\tO\nin\tO\nblood\tO\nof\tO\nrats\tO\nwere\tO\nanalyzed\tO\n.\tO\n\nMoreover\tO\nmRNA\tO\nlevels\tO\nof\tO\nLDLr\tO\nand\tO\nERK1\tO\n/\tO\n2\tO\nas\tO\nwell\tO\nas\tO\nprotein\tO\nlevels\tO\nof\tO\ntotal\tO\nand\tO\nactivated\tO\nforms\tO\nof\tO\nERK1\tO\n/\tO\n2\tO\nin\tO\nrat\tO\nliver\tO\nwere\tO\nevaluated\tO\nby\tO\nWestern\tO\nblotting\tO\nand\tO\nquantitative\tO\nreal\tO\ntime\tO\npolymerase\tO\nchain\tO\nreaction\tO\nanalysis\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOur\tO\ndata\tO\nshowed\tO\nthat\tO\nsubacute\tO\nexposure\tO\nto\tO\ndiazinon\tB-Chemical\nsignificantly\tO\nincreased\tO\nconcentrations\tO\nof\tO\ncholesterol\tB-Chemical\n,\tO\ntriglyceride\tB-Chemical\nand\tO\nLDL\tO\n.\tO\n\nMoreover\tO\ndiazinon\tB-Chemical\ndecreased\tO\nERK1\tO\n/\tO\n2\tO\nprotein\tO\nphosphorylation\tO\nand\tO\nLDLr\tO\ntranscript\tO\n.\tO\n\nCrocin\tB-Chemical\nreduced\tO\ninhibition\tO\nof\tO\nERK\tO\nactivation\tO\nand\tO\ndiazinon\tB-Chemical\n-\tO\ninduced\tO\nhyperlipemia\tB-Disease\nand\tO\nincreased\tO\nlevels\tO\nof\tO\nLDLr\tO\ntranscript\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCrocin\tB-Chemical\nmay\tO\nbe\tO\nconsidered\tO\nas\tO\na\tO\nnovel\tO\nprotective\tO\nagent\tO\nin\tO\ndiazinon\tB-Chemical\n-\tO\ninduced\tO\nhyperlipemia\tB-Disease\nthrough\tO\nmodulating\tO\nof\tO\nERK\tO\npathway\tO\nand\tO\nincrease\tO\nof\tO\nLDLr\tO\nexpression\tO\n.\tO\n\nGEM\tB-Chemical\n-\tO\nP\tO\nchemotherapy\tO\nis\tO\nactive\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nrelapsed\tO\nHodgkin\tB-Disease\nlymphoma\tI-Disease\n.\tO\n\nHodgkin\tB-Disease\nlymphoma\tI-Disease\n(\tO\nHL\tB-Disease\n)\tO\nis\tO\na\tO\nrelatively\tO\nchemosensitive\tO\nmalignancy\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nfor\tO\nthose\tO\nwho\tO\nrelapse\tO\n,\tO\nhigh\tO\n-\tO\ndose\tO\nchemotherapy\tO\nwith\tO\nautologous\tO\nstem\tO\ncell\tO\ntransplant\tO\nis\tO\nthe\tO\ntreatment\tO\nof\tO\nchoice\tO\nwhich\tO\nrelies\tO\non\tO\nadequate\tO\ndisease\tO\ncontrol\tO\nwith\tO\nsalvage\tO\nchemotherapy\tO\n.\tO\n\nRegimens\tO\ncommonly\tO\nused\tO\noften\tO\nrequire\tO\ninpatient\tO\nadministration\tO\nand\tO\ncan\tO\nbe\tO\ndifficult\tO\nto\tO\ndeliver\tO\ndue\tO\nto\tO\ntoxicity\tB-Disease\n.\tO\n\nGemcitabine\tB-Chemical\nand\tO\ncisplatin\tB-Chemical\nhave\tO\nactivity\tO\nin\tO\nHL\tB-Disease\n,\tO\nnon\tO\n-\tO\noverlapping\tO\ntoxicity\tB-Disease\nwith\tO\nfirst\tO\n-\tO\nline\tO\nchemotherapeutics\tO\n,\tO\nand\tO\nmay\tO\nbe\tO\ndelivered\tO\nin\tO\nan\tO\noutpatient\tO\nsetting\tO\n.\tO\n\nIn\tO\nthis\tO\nretrospective\tO\nsingle\tO\n-\tO\ncentre\tO\nanalysis\tO\n,\tO\npatients\tO\nwith\tO\nrelapsed\tO\nor\tO\nrefractory\tO\nHL\tB-Disease\ntreated\tO\nwith\tO\ngemcitabine\tB-Chemical\n1\tO\n,\tO\n000\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nday\tO\n(\tO\nD\tO\n)\tO\n1\tO\n,\tO\nD8\tO\nand\tO\nD15\tO\n;\tO\nmethylprednisolone\tB-Chemical\n1\tO\n,\tO\n000\tO\nmg\tO\nD1\tO\n-\tO\n5\tO\n;\tO\nand\tO\ncisplatin\tB-Chemical\n100\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nD15\tO\n,\tO\nevery\tO\n28\tO\ndays\tO\n(\tO\nGEM\tB-Chemical\n-\tO\nP\tO\n)\tO\nwere\tO\nincluded\tO\n.\tO\n\nDemographic\tO\n,\tO\nsurvival\tO\n,\tO\nresponse\tO\nand\tO\ntoxicity\tB-Disease\ndata\tO\nwere\tO\nrecorded\tO\n.\tO\n\nForty\tO\n-\tO\none\tO\neligible\tO\npatients\tO\nwere\tO\nidentified\tO\n:\tO\nmedian\tO\nage\tO\n27\tO\n.\tO\n\nOne\tO\nhundred\tO\nand\tO\ntwenty\tO\n-\tO\ntwo\tO\ncycles\tO\nof\tO\nGEM\tB-Chemical\n-\tO\nP\tO\nwere\tO\nadministered\tO\nin\tO\ntotal\tO\n(\tO\nmedian\tO\n3\tO\ncycles\tO\n;\tO\nrange\tO\n1\tO\n-\tO\n6\tO\n)\tO\n.\tO\n\nTwenty\tO\nof\tO\n41\tO\n(\tO\n48\tO\n%\tO\n)\tO\npatients\tO\nreceived\tO\nGEM\tB-Chemical\n-\tO\nP\tO\nas\tO\nsecond\tO\n-\tO\nline\tO\ntreatment\tO\nand\tO\n11\tO\n/\tO\n41\tO\n(\tO\n27\tO\n%\tO\n)\tO\nas\tO\nthird\tO\n-\tO\nline\tO\ntherapy\tO\n.\tO\n\nOverall\tO\nresponse\tO\nrate\tO\n(\tO\nORR\tO\n)\tO\nto\tO\nGEM\tB-Chemical\n-\tO\nP\tO\nin\tO\nthe\tO\nentire\tO\ncohort\tO\nwas\tO\n80\tO\n%\tO\n(\tO\ncomplete\tO\nresponse\tO\n(\tO\nCR\tO\n)\tO\n37\tO\n%\tO\n,\tO\npartial\tO\nresponse\tO\n44\tO\n%\tO\n)\tO\nwith\tO\n14\tO\n/\tO\n15\tO\nCR\tO\nconfirmed\tO\nas\tO\na\tO\nmetabolic\tO\nCR\tO\non\tO\nPET\tO\nand\tO\nORR\tO\nof\tO\n85\tO\n%\tO\nin\tO\nthe\tO\n20\tO\nsecond\tO\n-\tO\nline\tO\npatients\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\ngrade\tO\n3\tO\n/\tO\n4\tO\ntoxicities\tB-Disease\nwere\tO\nhaematological\tO\n:\tO\nneutropenia\tB-Disease\n54\tO\n%\tO\nand\tO\nthrombocytopenia\tB-Disease\n51\tO\n%\tO\n.\tO\n\nMedian\tO\nfollow\tO\n-\tO\nup\tO\nfrom\tO\nthe\tO\nstart\tO\nof\tO\nGEM\tB-Chemical\n-\tO\nP\tO\nwas\tO\n4\tO\n.\tO\n5\tO\nyears\tO\n.\tO\n\nFollowing\tO\nGEM\tB-Chemical\n-\tO\nP\tO\n,\tO\n5\tO\n-\tO\nyear\tO\nprogression\tO\n-\tO\nfree\tO\nsurvival\tO\nwas\tO\n46\tO\n%\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n(\tO\nCI\tO\n)\tO\n,\tO\n30\tO\n-\tO\n62\tO\n%\tO\n)\tO\nand\tO\n5\tO\n-\tO\nyear\tO\noverall\tO\nsurvival\tO\nwas\tO\n59\tO\n%\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n43\tO\n-\tO\n74\tO\n%\tO\n)\tO\n.\tO\n\nFourteen\tO\nof\tO\n41\tO\npatients\tO\nproceeded\tO\ndirectly\tO\nto\tO\nautologous\tO\ntransplant\tO\n.\tO\n\nGEM\tB-Chemical\n-\tO\nP\tO\nis\tO\na\tO\nsalvage\tO\nchemotherapy\tO\nwith\tO\nrelatively\tO\nhigh\tO\nresponse\tO\nrates\tO\n,\tO\nleading\tO\nto\tO\nsuccessful\tO\ntransplantation\tO\nin\tO\nappropriate\tO\npatients\tO\n,\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nrelapsed\tO\nor\tO\nrefractory\tO\nHL\tB-Disease\n.\tO\n\nBasal\tO\nfunctioning\tO\nof\tO\nthe\tO\nhypothalamic\tO\n-\tO\npituitary\tO\n-\tO\nadrenal\tO\n(\tO\nHPA\tO\n)\tO\naxis\tO\nand\tO\npsychological\tO\ndistress\tO\nin\tO\nrecreational\tO\necstasy\tB-Chemical\npolydrug\tO\nusers\tO\n.\tO\n\nRATIONALE\tO\n:\tO\nEcstasy\tB-Chemical\n(\tO\nMDMA\tB-Chemical\n)\tO\nis\tO\na\tO\npsychostimulant\tO\ndrug\tO\nwhich\tO\nis\tO\nincreasingly\tO\nassociated\tO\nwith\tO\npsychobiological\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nWhile\tO\nsome\tO\nrecent\tO\nstudies\tO\nsuggest\tO\nacute\tO\nchanges\tO\nin\tO\nneuroendocrine\tO\nfunction\tO\n,\tO\nless\tO\nis\tO\nknown\tO\nabout\tO\nlong\tO\n-\tO\nterm\tO\nchanges\tO\nin\tO\nHPA\tO\nfunctionality\tO\nin\tO\nrecreational\tO\nusers\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\ncurrent\tO\nstudy\tO\nis\tO\nthe\tO\nfirst\tO\nto\tO\nexplore\tO\nthe\tO\neffects\tO\nof\tO\necstasy\tB-Chemical\n-\tO\npolydrug\tO\nuse\tO\non\tO\npsychological\tO\ndistress\tO\nand\tO\nbasal\tO\nfunctioning\tO\nof\tO\nthe\tO\nHPA\tO\naxis\tO\nthrough\tO\nassessing\tO\nthe\tO\nsecretion\tO\nof\tO\ncortisol\tB-Chemical\nacross\tO\nthe\tO\ndiurnal\tO\nperiod\tO\n.\tO\n\nMETHOD\tO\n:\tO\nSeventy\tO\n-\tO\nsix\tO\nparticipants\tO\n(\tO\n21\tO\nnonusers\tO\n,\tO\n29\tO\nlight\tO\necstasy\tB-Chemical\n-\tO\npolydrug\tO\nusers\tO\n,\tO\n26\tO\nheavy\tO\necstasy\tB-Chemical\n-\tO\npolydrug\tO\nusers\tO\n)\tO\ncompleted\tO\na\tO\nsubstance\tO\nuse\tO\ninventory\tO\nand\tO\nmeasures\tO\nof\tO\npsychological\tO\ndistress\tO\nat\tO\nbaseline\tO\n,\tO\nthen\tO\ntwo\tO\nconsecutive\tO\ndays\tO\nof\tO\ncortisol\tB-Chemical\nsampling\tO\n(\tO\non\tO\nawakening\tO\n,\tO\n30\tO\nmin\tO\npost\tO\nawakening\tO\n,\tO\nbetween\tO\n1400\tO\nand\tO\n1600\tO\nhours\tO\nand\tO\npre\tO\nbedtime\tO\n)\tO\n.\tO\n\nOn\tO\nday\tO\n2\tO\n,\tO\nparticipants\tO\nalso\tO\nattended\tO\nthe\tO\nlaboratory\tO\nto\tO\ncomplete\tO\na\tO\n20\tO\n-\tO\nmin\tO\nmultitasking\tO\nstressor\tO\n.\tO\n\nRESULTS\tO\n:\tO\nBoth\tO\nuser\tO\ngroups\tO\nexhibited\tO\nsignificantly\tO\ngreater\tO\nlevels\tO\nof\tO\nanxiety\tB-Disease\nand\tO\ndepression\tB-Disease\nthan\tO\nnonusers\tO\n.\tO\n\nOn\tO\nday\tO\n1\tO\n,\tO\nall\tO\nparticipants\tO\nexhibited\tO\na\tO\ntypical\tO\ncortisol\tB-Chemical\nprofile\tO\n,\tO\nthough\tO\nlight\tO\nusers\tO\nhad\tO\nsignificantly\tO\nelevated\tO\nlevels\tO\npre\tO\n-\tO\nbed\tO\n.\tO\n\nOn\tO\nday\tO\n2\tO\n,\tO\nheavy\tO\nusers\tO\ndemonstrated\tO\nelevated\tO\nlevels\tO\nupon\tO\nawakening\tO\nand\tO\nall\tO\necstasy\tB-Chemical\n-\tO\npolydrug\tO\nusers\tO\ndemonstrated\tO\nelevated\tO\npre\tO\n-\tO\nbed\tO\nlevels\tO\ncompared\tO\nto\tO\nnon\tO\n-\tO\nusers\tO\n.\tO\n\nSignificant\tO\nbetween\tO\ngroup\tO\ndifferences\tO\nwere\tO\nalso\tO\nobserved\tO\nin\tO\nafternoon\tO\ncortisol\tB-Chemical\nlevels\tO\nand\tO\nin\tO\noverall\tO\ncortisol\tB-Chemical\nsecretion\tO\nacross\tO\nthe\tO\nday\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nincreases\tO\nin\tO\nanxiety\tB-Disease\nand\tO\ndepression\tB-Disease\nare\tO\nin\tO\nline\tO\nwith\tO\nprevious\tO\nobservations\tO\nin\tO\nrecreational\tO\necstasy\tB-Chemical\n-\tO\npolydrug\tO\nusers\tO\n.\tO\n\nDysregulated\tO\ndiurnal\tO\ncortisol\tB-Chemical\nmay\tO\nbe\tO\nindicative\tO\nof\tO\ninappropriate\tO\nanticipation\tO\nof\tO\nforthcoming\tO\ndemands\tO\nand\tO\nhypersecretion\tO\nmay\tO\nlead\tO\nto\tO\nthe\tO\nincreased\tO\npsychological\tO\nand\tO\nphysical\tO\nmorbidity\tO\nassociated\tO\nwith\tO\nheavy\tO\nrecreational\tO\nuse\tO\nof\tO\necstasy\tB-Chemical\n.\tO\n\nIfosfamide\tB-Chemical\nrelated\tO\nencephalopathy\tB-Disease\n:\tO\nthe\tO\nneed\tO\nfor\tO\na\tO\ntimely\tO\nEEG\tO\nevaluation\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIfosfamide\tB-Chemical\nis\tO\nan\tO\nalkylating\tO\nagent\tO\nuseful\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\na\tO\nwide\tO\nrange\tO\nof\tO\ncancers\tB-Disease\nincluding\tO\nsarcomas\tB-Disease\n,\tO\nlymphoma\tB-Disease\n,\tO\ngynecologic\tB-Disease\nand\tI-Disease\ntesticular\tI-Disease\ncancers\tI-Disease\n.\tO\n\nEncephalopathy\tB-Disease\nhas\tO\nbeen\tO\nreported\tO\nin\tO\n10\tO\n-\tO\n40\tO\n%\tO\nof\tO\npatients\tO\nreceiving\tO\nhigh\tO\n-\tO\ndose\tO\nIV\tO\nifosfamide\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nhighlight\tO\nthe\tO\nrole\tO\nof\tO\nelectroencephalogram\tO\n(\tO\nEEG\tO\n)\tO\nin\tO\nthe\tO\nearly\tO\ndetection\tO\nand\tO\nmanagement\tO\nof\tO\nifosfamide\tB-Chemical\nrelated\tO\nencephalopathy\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nRetrospective\tO\nchart\tO\nreview\tO\nincluding\tO\nclinical\tO\ndata\tO\nand\tO\nEEG\tO\nrecordings\tO\nwas\tO\ndone\tO\non\tO\nfive\tO\npatients\tO\n,\tO\nadmitted\tO\nto\tO\nMD\tO\nAnderson\tO\nCancer\tB-Disease\nCenter\tO\nbetween\tO\nyears\tO\n2009\tO\nand\tO\n2012\tO\n,\tO\nwho\tO\ndeveloped\tO\nifosfamide\tB-Chemical\nrelated\tO\nacute\tO\nencephalopathy\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\nfive\tO\npatients\tO\nexperienced\tO\nsymptoms\tO\nof\tO\nencephalopathy\tB-Disease\nsoon\tO\nafter\tO\n(\tO\nwithin\tO\n12\tO\nh\tO\n-\tO\n2\tO\ndays\tO\n)\tO\nreceiving\tO\nifosfamide\tB-Chemical\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\ngeneralized\tO\nconvulsions\tB-Disease\nwhile\tO\none\tO\npatient\tO\ndeveloped\tO\ncontinuous\tO\nnon\tB-Disease\n-\tI-Disease\nconvulsive\tI-Disease\nstatus\tI-Disease\nepilepticus\tI-Disease\n(\tO\nNCSE\tB-Disease\n)\tO\nthat\tO\nrequired\tO\nICU\tO\nadmission\tO\nand\tO\nintubation\tO\n.\tO\n\nInitial\tO\nEEG\tO\nshowed\tO\nepileptiform\tO\ndischarges\tO\nin\tO\nthree\tO\npatients\tO\n;\tO\nrun\tO\nof\tO\ntriphasic\tO\nwaves\tO\nin\tO\none\tO\npatient\tO\nand\tO\nmoderate\tO\ndegree\tO\ndiffuse\tO\ngeneralized\tO\nslowing\tO\n.\tO\n\nMixed\tO\npattern\tO\nwith\tO\nthe\tO\npresence\tO\nof\tO\nboth\tO\nsharps\tO\nand\tO\ntriphasic\tO\nwaves\tO\nwere\tO\nalso\tO\nnoted\tO\n.\tO\n\nRepeat\tO\nEEGs\tO\nwithin\tO\n24\tO\n_\tO\nh\tO\nof\tO\nsymptom\tO\nonset\tO\nshowed\tO\nmarked\tO\nimprovement\tO\nthat\tO\nwas\tO\ncorrelated\tO\nwith\tO\nclinical\tO\nimprovement\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSeverity\tO\nof\tO\nifosfamide\tB-Chemical\nrelated\tO\nencephalopathy\tB-Disease\ncorrelates\tO\nwith\tO\nEEG\tO\nchanges\tO\n.\tO\n\nWe\tO\nsuggest\tO\na\tO\ntimely\tO\nEEG\tO\nevaluation\tO\nfor\tO\npatients\tO\nreceiving\tO\nifosfamide\tB-Chemical\nwho\tO\ndevelop\tO\nfeatures\tO\nof\tO\nencephalopathy\tB-Disease\n.\tO\n\nIncidence\tO\nof\tO\ncontrast\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\nin\tO\nhospitalised\tO\npatients\tO\nwith\tO\ncancer\tB-Disease\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nfrequency\tO\nof\tO\nand\tO\npossible\tO\nfactors\tO\nrelated\tO\nto\tO\ncontrast\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n(\tO\nCIN\tO\n)\tO\nin\tO\nhospitalised\tO\npatients\tO\nwith\tO\ncancer\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nNinety\tO\nadult\tO\npatients\tO\nwere\tO\nenrolled\tO\n.\tO\n\nPatients\tO\nwith\tO\nrisk\tO\nfactors\tO\nfor\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nwere\tO\nexcluded\tO\n.\tO\n\nBlood\tO\nsamples\tO\nwere\tO\nexamined\tO\nthe\tO\nday\tO\nbefore\tO\ncontrast\tB-Chemical\n-\tO\nenhanced\tO\ncomputed\tO\ntomography\tO\n(\tO\nCT\tO\n)\tO\nand\tO\nserially\tO\nfor\tO\n3\tO\ndays\tO\nthereafter\tO\n.\tO\n\nCIN\tO\nwas\tO\ndefined\tO\nas\tO\nan\tO\nincrease\tO\nin\tO\nserum\tO\ncreatinine\tB-Chemical\n(\tO\nCr\tB-Chemical\n)\tO\nof\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\nor\tO\nmore\tO\n,\tO\nor\tO\nelevation\tO\nof\tO\nCr\tB-Chemical\nto\tO\n25\tO\n%\tO\nover\tO\nbaseline\tO\n.\tO\n\nRelationships\tO\nbetween\tO\nCIN\tO\nand\tO\npossible\tO\nrisk\tO\nfactors\tO\nwere\tO\ninvestigated\tO\n.\tO\n\nRESULTS\tO\n:\tO\nCIN\tO\nwas\tO\ndetected\tO\nin\tO\n18\tO\n/\tO\n90\tO\n(\tO\n20\tO\n%\tO\n)\tO\npatients\tO\n.\tO\n\nCIN\tO\ndeveloped\tO\nin\tO\n25\tO\n.\tO\n5\tO\n%\tO\npatients\tO\nwho\tO\nunderwent\tO\nchemotherapy\tO\nand\tO\nin\tO\n11\tO\n%\tO\npatients\tO\nwho\tO\ndid\tO\nnot\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n1\tO\n)\tO\n.\tO\n\nCIN\tO\nmore\tO\nfrequently\tO\ndeveloped\tO\nin\tO\npatients\tO\nwho\tO\nhad\tO\nundergone\tO\nCT\tO\nwithin\tO\n45\tO\ndays\tO\nafter\tO\nthe\tO\nlast\tO\nchemotherapy\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n005\tO\n)\tO\n;\tO\nit\tO\nwas\tO\nalso\tO\nan\tO\nindependent\tO\nrisk\tO\nfactor\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n017\tO\n)\tO\n.\tO\n\nCIN\tO\nwas\tO\nsignificantly\tO\nmore\tO\nafter\tO\ntreatment\tO\nwith\tO\nbevacizumab\tB-Chemical\n/\tO\nirinotecan\tB-Chemical\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n021\tO\n)\tO\nand\tO\nin\tO\npatients\tO\nwith\tO\nhypertension\tB-Disease\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n044\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nincidence\tO\nof\tO\nCIN\tO\nafter\tO\nCT\tO\nin\tO\nhospitalised\tO\noncological\tO\npatients\tO\nwas\tO\n20\tO\n%\tO\n.\tO\n\nCIN\tO\ndeveloped\tO\n4\tO\n.\tO\n5\tO\n-\tO\ntimes\tO\nmore\tO\nfrequently\tO\nin\tO\npatients\tO\nwith\tO\ncancer\tB-Disease\nwho\tO\nhad\tO\nundergone\tO\nrecent\tO\nchemotherapy\tO\n.\tO\n\nHypertension\tB-Disease\nand\tO\nthe\tO\ncombination\tO\nof\tO\nbevacizumab\tB-Chemical\n/\tO\nirinotecan\tB-Chemical\nmay\tO\nbe\tO\nadditional\tO\nrisk\tO\nfactors\tO\nfor\tO\nCIN\tO\ndevelopment\tO\n.\tO\n\nKEY\tO\nPOINTS\tO\n:\tO\n.\tO\n\nContrast\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n(\tO\nCIN\tO\n)\tO\nis\tO\na\tO\nconcern\tO\nfor\tO\noncological\tO\npatients\tO\nundergoing\tO\nCT\tO\n.\tO\n\n.\tO\nCIN\tO\noccurs\tO\nmore\tO\noften\tO\nwhen\tO\nCT\tO\nis\tO\nperformed\tO\n<\tO\n45\tO\ndays\tO\nafter\tO\nchemotherapy\tO\n.\tO\n\n.\tO\nHypertension\tB-Disease\nand\tO\ntreatment\tO\nwith\tO\nbevacizumab\tB-Chemical\nappear\tO\nto\tO\nbe\tO\nadditional\tO\nrisk\tO\nfactors\tO\n.\tO\n\nSyndrome\tB-Disease\nof\tI-Disease\ninappropriate\tI-Disease\nantidiuretic\tI-Disease\nhormone\tI-Disease\nsecretion\tO\nassociated\tO\nwith\tO\ndesvenlafaxine\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nsyndrome\tB-Disease\nof\tI-Disease\ninappropriate\tI-Disease\nanti\tI-Disease\n-\tI-Disease\ndiuretic\tI-Disease\nhormone\tI-Disease\n(\tO\nSIADH\tB-Disease\n)\tO\nsecretion\tO\nassociated\tO\nwith\tO\ndesvenlafaxine\tB-Chemical\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n57\tO\n-\tO\nyear\tO\nold\tO\nfemale\tO\nwith\tO\nhyponatraemia\tB-Disease\n.\tO\n\nHer\tO\nmedications\tO\nincluded\tO\ndesvenlafaxine\tB-Chemical\n,\tO\nand\tO\nsymptoms\tO\nincluded\tO\nnausea\tB-Disease\n,\tO\nanxiety\tB-Disease\nand\tO\nconfusion\tB-Disease\n.\tO\n\nThe\tO\nserum\tO\nsodium\tB-Chemical\nat\tO\nthis\tO\ntime\tO\nwas\tO\n120\tO\nmmol\tO\n/\tO\nL\tO\n,\tO\nserum\tO\nosmolality\tO\nwas\tO\n263\tO\nmosmol\tO\n/\tO\nkg\tO\n,\tO\nurine\tO\nosmolality\tO\n410\tO\nmosmol\tO\n/\tO\nkg\tO\nand\tO\nurine\tO\nsodium\tB-Chemical\n63\tO\nmmol\tO\n/\tO\nL\tO\n,\tO\nconsistent\tO\nwith\tO\na\tO\ndiagnosis\tO\nof\tO\nSIADH\tB-Disease\n.\tO\n\nDesvenlafaxine\tB-Chemical\nwas\tO\nceased\tO\nand\tO\nfluid\tO\nrestriction\tO\nimplemented\tO\n.\tO\n\nAfter\tO\n4\tO\ndays\tO\nthe\tO\nsodium\tB-Chemical\nincreased\tO\nto\tO\n128\tO\nmmol\tO\n/\tO\nL\tO\nand\tO\nfluid\tO\nrestriction\tO\nwas\tO\nrelaxed\tO\n.\tO\n\nDuring\tO\nher\tO\nfurther\tO\n3\tO\nweeks\tO\ninpatient\tO\nadmission\tO\nthe\tO\nserum\tO\nsodium\tB-Chemical\nranged\tO\nfrom\tO\n134\tO\nto\tO\n137\tO\nmmol\tO\n/\tO\nL\tO\nduring\tO\ntreatment\tO\nwith\tO\nmirtazapine\tB-Chemical\n.\tO\n\nDISCUSSION\tO\n:\tO\nSIADH\tB-Disease\nhas\tO\nbeen\tO\nwidely\tO\nreported\tO\nwith\tO\na\tO\nrange\tO\nof\tO\nantidepressants\tO\n.\tO\n\nThis\tO\ncase\tO\nreport\tO\nsuggests\tO\nthat\tO\ndesvenlafaxine\tB-Chemical\nmight\tO\ncause\tO\nclinically\tO\nsignificant\tO\nhyponatremia\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nClinicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthe\tO\npotential\tO\nfor\tO\nantidepressants\tO\nto\tO\ncause\tO\nhyponatremia\tB-Disease\n,\tO\nand\tO\ntake\tO\nappropriate\tO\ncorrective\tO\naction\tO\nwhere\tO\nnecessary\tO\n.\tO\n\nOxidative\tO\nstress\tO\non\tO\ncardiotoxicity\tB-Disease\nafter\tO\ntreatment\tO\nwith\tO\nsingle\tO\nand\tO\nmultiple\tO\ndoses\tO\nof\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nremains\tO\ncontroversial\tO\n.\tO\n\nWistar\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n66\tO\n)\tO\nreceived\tO\nDOX\tB-Chemical\ninjections\tO\nintraperitoneally\tO\nand\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\n2\tO\nexperimental\tO\nprotocols\tO\n:\tO\n(\tO\n1\tO\n)\tO\nrats\tO\nwere\tO\nkilled\tO\nbefore\tO\n(\tO\n-\tO\n24\tO\nh\tO\n,\tO\nn\tO\n=\tO\n8\tO\n)\tO\nand\tO\n24\tO\nh\tO\nafter\tO\n(\tO\n+\tO\n24\tO\nh\tO\n,\tO\nn\tO\n=\tO\n8\tO\n)\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nDOX\tB-Chemical\n(\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n)\tO\nto\tO\ndetermine\tO\nthe\tO\nDOX\tB-Chemical\nacute\tO\neffect\tO\nand\tO\n(\tO\n2\tO\n)\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n58\tO\n)\tO\nreceived\tO\n4\tO\ninjections\tO\nof\tO\nDOX\tB-Chemical\n(\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n/\tO\nweek\tO\n)\tO\nand\tO\nwere\tO\nkilled\tO\nbefore\tO\nthe\tO\nfirst\tO\ninjection\tO\n(\tO\nM0\tO\n)\tO\nand\tO\n1\tO\nweek\tO\nafter\tO\neach\tO\ninjection\tO\n(\tO\nM1\tO\n,\tO\nM2\tO\n,\tO\nM3\tO\n,\tO\nand\tO\nM4\tO\n)\tO\nto\tO\ndetermine\tO\nthe\tO\nchronological\tO\neffects\tO\n.\tO\n\nAnimals\tO\nused\tO\nat\tO\nM0\tO\n(\tO\nn\tO\n=\tO\n8\tO\n)\tO\nwere\tO\nalso\tO\nused\tO\nat\tO\nmoment\tO\n-\tO\n24\tO\nh\tO\nof\tO\nacute\tO\nstudy\tO\n.\tO\n\nCardiac\tO\ntotal\tO\nantioxidant\tO\nperformance\tO\n(\tO\nTAP\tO\n)\tO\n,\tO\nDNA\tO\ndamage\tO\n,\tO\nand\tO\nmorphology\tO\nanalyses\tO\nwere\tO\ncarried\tO\nout\tO\nat\tO\neach\tO\ntime\tO\npoint\tO\n.\tO\n\nSingle\tO\ndose\tO\nof\tO\nDOX\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\nincreased\tO\ncardiac\tB-Disease\ndisarrangement\tI-Disease\n,\tO\nnecrosis\tB-Disease\n,\tO\nand\tO\nDNA\tO\ndamage\tO\n(\tO\nstrand\tO\nbreaks\tO\n(\tO\nSBs\tO\n)\tO\nand\tO\noxidized\tO\npyrimidines\tO\n)\tO\nand\tO\ndecreased\tO\nTAP\tO\n.\tO\n\nThe\tO\nchronological\tO\nstudy\tO\nshowed\tO\nan\tO\neffect\tO\nof\tO\na\tO\ncumulative\tO\ndose\tO\non\tO\nbody\tO\nweight\tO\n(\tO\nR\tO\n=\tO\n-\tO\n0\tO\n.\tO\n99\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n011\tO\n)\tO\n,\tO\nnecrosis\tB-Disease\n(\tO\nR\tO\n=\tO\n1\tO\n.\tO\n00\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n004\tO\n)\tO\n,\tO\nTAP\tO\n(\tO\nR\tO\n=\tO\n0\tO\n.\tO\n95\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n049\tO\n)\tO\n,\tO\nand\tO\nDNA\tO\nSBs\tO\n(\tO\nR\tO\n=\tO\n-\tO\n0\tO\n.\tO\n95\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n049\tO\n)\tO\n.\tO\n\nDNA\tO\nSBs\tO\ndamage\tO\nwas\tO\nnegatively\tO\nassociated\tO\nwith\tO\nTAP\tO\n(\tO\nR\tO\n=\tO\n-\tO\n0\tO\n.\tO\n98\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n018\tO\n)\tO\n,\tO\nand\tO\nnecrosis\tB-Disease\n(\tO\nR\tO\n=\tO\n-\tO\n0\tO\n.\tO\n97\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n027\tO\n)\tO\n.\tO\n\nOur\tO\nresults\tO\nsuggest\tO\nthat\tO\noxidative\tO\ndamage\tO\nis\tO\nassociated\tO\nwith\tO\nacute\tO\ncardiotoxicity\tB-Disease\ninduced\tO\nby\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nDOX\tB-Chemical\nonly\tO\n.\tO\n\nIncreased\tO\nresistance\tO\nto\tO\nthe\tO\noxidative\tO\nstress\tO\nis\tO\nplausible\tO\nfor\tO\nthe\tO\nmultiple\tO\ndose\tO\nof\tO\nDOX\tB-Chemical\n.\tO\n\nThus\tO\n,\tO\ndifferent\tO\nmechanisms\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nacute\tO\ntoxicity\tB-Disease\nversus\tO\nchronic\tO\ntoxicity\tB-Disease\n.\tO\n\nTacrolimus\tB-Chemical\n-\tO\nrelated\tO\nseizure\tB-Disease\nafter\tO\npediatric\tO\nliver\tO\ntransplantation\tO\n-\tO\n-\tO\na\tO\nsingle\tO\n-\tO\ncenter\tO\nexperience\tO\n.\tO\n\nTo\tO\nidentify\tO\nthe\tO\nrisk\tO\nfactors\tO\nfor\tO\nnew\tO\n-\tO\nonset\tO\nseizures\tB-Disease\nafter\tO\npediatric\tO\nLT\tO\nand\tO\nto\tO\nassess\tO\ntheir\tO\nclinical\tO\nimplications\tO\nand\tO\nlong\tO\n-\tO\nterm\tO\nprognosis\tO\n.\tO\n\nThe\tO\nclinical\tO\nand\tO\nlaboratory\tO\ndata\tO\nof\tO\n27\tO\nconsecutive\tO\nchildren\tO\nwho\tO\nunderwent\tO\nLT\tO\nfrom\tO\nJanuary\tO\n2007\tO\nto\tO\nDecember\tO\n2010\tO\nin\tO\nour\tO\ncenter\tO\nwere\tO\nanalyzed\tO\nretrospectively\tO\n.\tO\n\nPatients\tO\nwere\tO\ndivided\tO\ninto\tO\nseizures\tB-Disease\ngroup\tO\nand\tO\na\tO\nnon\tO\n-\tO\nseizures\tB-Disease\ngroup\tO\n.\tO\n\nPre\tO\n-\tO\noperative\tO\n,\tO\nintra\tO\n-\tO\noperative\tO\n,\tO\nand\tO\npost\tO\n-\tO\noperative\tO\ndata\tO\nwere\tO\ncollected\tO\n.\tO\n\nSeizures\tB-Disease\noccurred\tO\nin\tO\nfour\tO\nchildren\tO\n,\tO\nan\tO\nincidence\tO\nof\tO\n14\tO\n.\tO\n8\tO\n%\tO\n.\tO\n\nAll\tO\nexhibited\tO\ngeneralized\tO\ntonic\tB-Disease\n-\tI-Disease\nclonic\tI-Disease\nseizures\tI-Disease\nwithin\tO\nthe\tO\nfirst\tO\ntwo\tO\nwk\tO\nafter\tO\nLT\tO\n.\tO\n\nUnivariate\tO\nanalysis\tO\nshowed\tO\nthat\tO\nthe\tO\nrisk\tO\nfactors\tO\nassociated\tO\nwith\tO\nseizures\tB-Disease\nafter\tO\npediatric\tO\nLT\tO\nincluded\tO\ngender\tO\n,\tO\npediatric\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nliver\tI-Disease\ndisease\tI-Disease\nscore\tO\nbefore\tO\nsurgery\tO\n,\tO\nChild\tO\n-\tO\nPugh\tO\nscore\tO\nbefore\tO\nsurgery\tO\n,\tO\nserum\tO\ntotal\tO\nbilirubin\tB-Chemical\nafter\tO\nsurgery\tO\n,\tO\nand\tO\ntrough\tO\nTAC\tB-Chemical\nlevel\tO\n.\tO\n\nMultivariate\tO\nanalysis\tO\nshowed\tO\nthat\tO\ntrough\tO\nTAC\tB-Chemical\nlevel\tO\nwas\tO\nthe\tO\nonly\tO\nindependent\tO\nrisk\tO\nfactor\tO\nassociated\tO\nwith\tO\nthe\tO\nseizures\tB-Disease\n.\tO\n\nAll\tO\nchildren\tO\nwho\tO\nexperienced\tO\nseizures\tB-Disease\nsurvived\tO\nwith\tO\ngood\tO\ngraft\tO\nfunction\tO\nand\tO\nremained\tO\nseizure\tB-Disease\n-\tO\nfree\tO\nwithout\tO\nanti\tO\n-\tO\nepileptic\tB-Disease\ndrugs\tO\nover\tO\na\tO\nmean\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\nof\tO\n33\tO\n.\tO\n7\tO\n+\tO\n14\tO\n.\tO\n6\tO\nmonths\tO\n.\tO\n\nHigh\tO\ntrough\tO\nTAC\tB-Chemical\nlevel\tO\nwas\tO\nthe\tO\npredominant\tO\nfactor\tO\nthat\tO\ncontributed\tO\nto\tO\nseizures\tB-Disease\nin\tO\nthe\tO\nearly\tO\npost\tO\n-\tO\noperative\tO\nperiod\tO\nafter\tO\npediatric\tO\nLT\tO\n.\tO\n\nHigh\tO\nPELD\tO\nand\tO\nChild\tO\n-\tO\nPugh\tO\nscores\tO\nbefore\tO\nLT\tO\nand\tO\nhigh\tO\npost\tO\n-\tO\noperative\tO\nserum\tO\nTbil\tO\nmay\tO\nbe\tO\ncontributory\tO\nrisk\tO\nfactors\tO\nfor\tO\nTAC\tB-Chemical\n-\tO\nrelated\tO\nseizures\tB-Disease\n.\tO\n\nThe\tO\nflavonoid\tB-Chemical\napigenin\tB-Chemical\ndelays\tO\nforgetting\tO\nof\tO\npassive\tO\navoidance\tO\nconditioning\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npresent\tO\nexperiments\tO\nwere\tO\nperformed\tO\nto\tO\nstudy\tO\nthe\tO\neffect\tO\nof\tO\nthe\tO\nflavonoid\tB-Chemical\napigenin\tB-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\nintraperitoneally\tO\n(\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\n1\tO\nh\tO\nbefore\tO\nacquisition\tO\n)\tO\n,\tO\non\tO\n24\tO\nh\tO\nretention\tO\nperformance\tO\nand\tO\nforgetting\tO\nof\tO\na\tO\nstep\tO\n-\tO\nthrough\tO\npassive\tO\navoidance\tO\ntask\tO\n,\tO\nin\tO\nyoung\tO\nmale\tO\nWistar\tO\nrats\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\ndifferences\tO\nbetween\tO\nsaline\tO\n-\tO\nand\tO\napigenin\tB-Chemical\n-\tO\ntreated\tO\ngroups\tO\nin\tO\nthe\tO\n24\tO\nh\tO\nretention\tO\ntrial\tO\n.\tO\n\nFurthermore\tO\n,\tO\napigenin\tB-Chemical\ndid\tO\nnot\tO\nprevent\tO\nthe\tO\namnesia\tB-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\n(\tO\n1mg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\n30\tO\nmin\tO\nbefore\tO\nthe\tO\nacquisition\tO\n)\tO\n.\tO\n\nThe\tO\nsaline\tO\n-\tO\nand\tO\napigenin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nthat\tO\ndid\tO\nnot\tO\nstep\tO\nthrough\tO\ninto\tO\nthe\tO\ndark\tO\ncompartment\tO\nduring\tO\nthe\tO\ncut\tO\n-\tO\noff\tO\ntime\tO\n(\tO\n540\tO\ns\tO\n)\tO\nwere\tO\nretested\tO\nweekly\tO\nfor\tO\nup\tO\nto\tO\neight\tO\nweeks\tO\n.\tO\n\nIn\tO\nthe\tO\nsaline\tO\ntreated\tO\ngroup\tO\n,\tO\nthe\tO\nfirst\tO\nsignificant\tO\ndecline\tO\nin\tO\npassive\tO\navoidance\tO\nresponse\tO\nwas\tO\nobserved\tO\nat\tO\nfour\tO\nweeks\tO\n,\tO\nand\tO\ncomplete\tO\nmemory\tB-Disease\nloss\tI-Disease\nwas\tO\nfound\tO\nfive\tO\nweeks\tO\nafter\tO\nthe\tO\nacquisition\tO\nof\tO\nthe\tO\npassive\tO\navoidance\tO\ntask\tO\n.\tO\n\nAt\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nexperimental\tO\nperiod\tO\n,\tO\n60\tO\n%\tO\nof\tO\nthe\tO\nanimals\tO\ntreated\tO\nwith\tO\napigenin\tB-Chemical\nstill\tO\ndid\tO\nnot\tO\nstep\tO\nthrough\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\n1\tO\n)\tO\napigenin\tB-Chemical\ndelays\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nforgetting\tO\nbut\tO\ndid\tO\nnot\tO\nmodulate\tO\nthe\tO\n24\tO\nh\tO\nretention\tO\nof\tO\nfear\tO\nmemory\tO\nand\tO\n2\tO\n)\tO\nthe\tO\nobtained\tO\nbeneficial\tO\neffect\tO\nof\tO\napigenin\tB-Chemical\non\tO\nthe\tO\npassive\tO\navoidance\tO\nconditioning\tO\nis\tO\nmediated\tO\nby\tO\nmechanisms\tO\nthat\tO\ndo\tO\nnot\tO\nimplicate\tO\nits\tO\naction\tO\non\tO\nthe\tO\nmuscarinic\tO\ncholinergic\tO\nsystem\tO\n.\tO\n\nHistamine\tB-Chemical\nantagonists\tO\nand\tO\nd\tB-Chemical\n-\tI-Chemical\ntubocurarine\tI-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nin\tO\ncardiac\tO\nsurgical\tO\npatients\tO\n.\tO\n\nHemodynamic\tO\neffects\tO\nand\tO\nhistamine\tB-Chemical\nrelease\tO\nby\tO\nbolus\tO\ninjection\tO\nof\tO\n0\tO\n.\tO\n35\tO\nmg\tO\n/\tO\nkg\tO\nof\tO\nd\tB-Chemical\n-\tI-Chemical\ntubocurarine\tI-Chemical\nwere\tO\nstudied\tO\nin\tO\n24\tO\npatients\tO\n.\tO\n\nH1\tO\n-\tO\nand\tO\nH2\tO\n-\tO\nhistamine\tB-Chemical\nantagonists\tO\nor\tO\nplacebo\tO\nwere\tO\ngiven\tO\nbefore\tO\ndosing\tO\nwith\tO\nd\tB-Chemical\n-\tI-Chemical\ntubocurarine\tI-Chemical\nin\tO\na\tO\nrandomized\tO\ndouble\tO\n-\tO\nblind\tO\nfashion\tO\nto\tO\nfour\tO\ngroups\tO\n:\tO\ngroup\tO\n1\tO\n-\tO\n-\tO\nplacebo\tO\n;\tO\ngroup\tO\n2\tO\n-\tO\n-\tO\ncimetidine\tB-Chemical\n,\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nplus\tO\nplacebo\tO\n;\tO\ngroup\tO\n3\tO\n-\tO\n-\tO\nchlorpheniramine\tB-Chemical\n,\tO\n0\tO\n.\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nplus\tO\nplacebo\tO\n;\tO\nand\tO\ngroup\tO\n4\tO\n-\tO\n-\tO\ncimetidine\tB-Chemical\nplus\tO\nchlorpheniramine\tB-Chemical\n.\tO\n\nHistamine\tB-Chemical\nrelease\tO\noccurred\tO\nin\tO\nmost\tO\npatients\tO\n,\tO\nthe\tO\nhighest\tO\nlevel\tO\n2\tO\nminutes\tO\nafter\tO\nd\tB-Chemical\n-\tI-Chemical\ntubocurarine\tI-Chemical\ndosing\tO\n.\tO\n\nGroup\tO\n1\tO\nhad\tO\na\tO\nmoderate\tO\nnegative\tO\ncorrelation\tO\nbetween\tO\nplasma\tO\nhistamine\tB-Chemical\nchange\tO\nand\tO\nsystemic\tO\nvascular\tO\nresistance\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n58\tO\n;\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nnot\tO\npresent\tO\nin\tO\ngroup\tO\n4\tO\n.\tO\n\nPrior\tO\ndosing\tO\nwith\tO\nantagonists\tO\npartially\tO\nprevented\tO\nthe\tO\nfall\tO\nin\tO\nsystemic\tO\nvascular\tO\nresistance\tO\n.\tO\n\nThese\tO\ndata\tO\ndemonstrate\tO\nthat\tO\nthe\tO\nhemodynamic\tO\nchanges\tO\nassociated\tO\nwith\tO\nd\tB-Chemical\n-\tI-Chemical\ntubocurarine\tI-Chemical\ndosing\tO\nare\tO\nonly\tO\npartially\tO\nexplained\tO\nby\tO\nhistamine\tB-Chemical\nrelease\tO\n.\tO\n\nThus\tO\nprior\tO\ndosing\tO\nwith\tO\nH1\tO\n-\tO\nand\tO\nH2\tO\n-\tO\nantagonists\tO\nprovides\tO\nonly\tO\npartial\tO\nprotection\tO\n.\tO\n\nCholecystokinin\tB-Chemical\n-\tI-Chemical\noctapeptide\tI-Chemical\nrestored\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nhippocampal\tO\nlong\tO\n-\tO\nterm\tO\npotentiation\tO\nimpairment\tO\nin\tO\nrats\tO\n.\tO\n\nCholecystokinin\tB-Chemical\n-\tI-Chemical\noctapeptide\tI-Chemical\n(\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n)\tO\n,\tO\nwhich\tO\nis\tO\na\tO\ntypical\tO\nbrain\tO\n-\tO\ngut\tO\npeptide\tO\n,\tO\nexerts\tO\na\tO\nwide\tO\nrange\tO\nof\tO\nbiological\tO\nactivities\tO\non\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nWe\tO\nhave\tO\npreviously\tO\nreported\tO\nthat\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\nsignificantly\tO\nalleviated\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\nand\tO\nreversed\tO\nspine\tO\ndensity\tO\ndecreases\tO\nin\tO\nthe\tO\nCA1\tO\nregion\tO\nof\tO\nthe\tO\nhippocampus\tO\nin\tO\nmorphine\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\n.\tO\n\nHere\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\neffects\tO\nof\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\non\tO\nlong\tO\n-\tO\nterm\tO\npotentiation\tO\n(\tO\nLTP\tO\n)\tO\nin\tO\nthe\tO\nlateral\tO\nperforant\tO\npath\tO\n(\tO\nLPP\tO\n)\tO\n-\tO\ngranule\tO\ncell\tO\nsynapse\tO\nof\tO\nrat\tO\ndentate\tO\ngyrus\tO\n(\tO\nDG\tO\n)\tO\nin\tO\nacute\tO\nsaline\tO\nor\tO\nmorphine\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nPopulation\tO\nspikes\tO\n(\tO\nPS\tO\n)\tO\n,\tO\nwhich\tO\nwere\tO\nevoked\tO\nby\tO\nstimulation\tO\nof\tO\nthe\tO\nLPP\tO\n,\tO\nwere\tO\nrecorded\tO\nin\tO\nthe\tO\nDG\tO\nregion\tO\n.\tO\n\nAcute\tO\nmorphine\tB-Chemical\n(\tO\n30mg\tO\n/\tO\nkg\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\ntreatment\tO\nsignificantly\tO\nattenuated\tO\nhippocampal\tO\nLTP\tO\nand\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n(\tO\n1ug\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\nrestored\tO\nthe\tO\namplitude\tO\nof\tO\nPS\tO\nthat\tO\nwas\tO\nattenuated\tO\nby\tO\nmorphine\tB-Chemical\ninjection\tO\n.\tO\n\nFurthermore\tO\n,\tO\nmicroinjection\tO\nof\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nand\tO\n1ug\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\nalso\tO\nsignificantly\tO\naugmented\tO\nhippocampal\tO\nLTP\tO\nin\tO\nsaline\tO\n-\tO\ntreated\tO\n(\tO\n1ml\tO\n/\tO\nkg\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nrats\tO\n.\tO\n\nPre\tO\n-\tO\ntreatment\tO\nof\tO\nthe\tO\nCCK2\tO\nreceptor\tO\nantagonist\tO\nL\tO\n-\tO\n365\tO\n,\tO\n260\tO\n(\tO\n10ug\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n)\tO\nreversed\tO\nthe\tO\neffects\tO\nof\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n,\tO\nbut\tO\nthe\tO\nCCK1\tO\nreceptor\tO\nantagonist\tO\nL\tO\n-\tO\n364\tO\n,\tO\n718\tO\n(\tO\n10ug\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n)\tO\ndid\tO\nnot\tO\n.\tO\n\nThe\tO\npresent\tO\nresults\tO\ndemonstrate\tO\nthat\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\nattenuates\tO\nthe\tO\neffect\tO\nof\tO\nmorphine\tB-Chemical\non\tO\nhippocampal\tO\nLTP\tO\nthrough\tO\nCCK2\tO\nreceptors\tO\nand\tO\nsuggest\tO\nan\tO\nameliorative\tO\nfunction\tO\nof\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\non\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nmemory\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nGlial\tO\nactivation\tO\nand\tO\npost\tO\n-\tO\nsynaptic\tO\nneurotoxicity\tB-Disease\n:\tO\nthe\tO\nkey\tO\nevents\tO\nin\tO\nStreptozotocin\tB-Chemical\n(\tO\nICV\tO\n)\tO\ninduced\tO\nmemory\tB-Disease\nimpairment\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\nthe\tO\nrole\tO\nof\tO\nglial\tO\nactivation\tO\nand\tO\npost\tO\nsynaptic\tO\ntoxicity\tB-Disease\nin\tO\nICV\tO\nStreptozotocin\tB-Chemical\n(\tO\nSTZ\tB-Chemical\n)\tO\ninduced\tO\nmemory\tB-Disease\nimpaired\tI-Disease\nrats\tO\nwas\tO\nexplored\tO\n.\tO\n\nIn\tO\nexperiment\tO\nset\tO\nup\tO\n1\tO\n:\tO\nMemory\tB-Disease\ndeficit\tI-Disease\nwas\tO\nfound\tO\nin\tO\nMorris\tO\nwater\tO\nmaze\tO\ntest\tO\non\tO\n14\tO\n-\tO\n16\tO\ndays\tO\nafter\tO\nSTZ\tB-Chemical\n(\tO\nICV\tO\n;\tO\n3mg\tO\n/\tO\nKg\tO\n)\tO\nadministration\tO\n.\tO\n\nSTZ\tB-Chemical\ncauses\tO\nincreased\tO\nexpression\tO\nof\tO\nGFAP\tO\n,\tO\nCD11b\tO\nand\tO\nTNF\tO\n-\tO\na\tO\nindicating\tO\nglial\tO\nactivation\tO\nand\tO\nneuroinflammation\tB-Disease\n.\tO\n\nSTZ\tB-Chemical\nalso\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nlevel\tO\nof\tO\nROS\tO\n,\tO\nnitrite\tB-Chemical\n,\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nand\tO\nreduced\tO\nthe\tO\nmitochondrial\tO\nactivity\tO\nin\tO\nsynaptosomal\tO\npreparation\tO\nillustrating\tO\nfree\tO\nradical\tO\ngeneration\tO\nand\tO\nexcitotoxicity\tB-Disease\n.\tO\n\nIncreased\tO\nexpression\tO\nand\tO\nactivity\tO\nof\tO\nCaspase\tO\n-\tO\n3\tO\nwas\tO\nalso\tO\nobserved\tO\nin\tO\nSTZ\tB-Chemical\ntreated\tO\nrat\tO\nwhich\tO\nspecify\tO\napoptotic\tO\ncell\tO\ndeath\tO\nin\tO\nhippocampus\tO\nand\tO\ncortex\tO\n.\tO\n\nSTZ\tB-Chemical\ntreatment\tO\nshowed\tO\ndecrease\tO\nexpression\tO\nof\tO\npost\tO\nsynaptic\tO\nmarkers\tO\nCaMKIIa\tO\nand\tO\nPSD\tO\n-\tO\n95\tO\n,\tO\nwhile\tO\n,\tO\nexpression\tO\nof\tO\npre\tO\nsynaptic\tO\nmarkers\tO\n(\tO\nsynaptophysin\tO\nand\tO\nSNAP\tO\n-\tO\n25\tO\n)\tO\nremains\tO\nunaltered\tO\nindicating\tO\nselective\tO\npost\tO\nsynaptic\tO\nneurotoxicity\tB-Disease\n.\tO\n\nOral\tO\ntreatment\tO\nwith\tO\nMemantine\tB-Chemical\n(\tO\n10mg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\nIbuprofen\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ndaily\tO\nfor\tO\n13\tO\ndays\tO\nattenuated\tO\nSTZ\tB-Chemical\ninduced\tO\nglial\tO\nactivation\tO\n,\tO\napoptotic\tO\ncell\tO\ndeath\tO\nand\tO\npost\tO\nsynaptic\tO\nneurotoxicity\tB-Disease\nin\tO\nrat\tO\nbrain\tO\n.\tO\n\nFurther\tO\n,\tO\nin\tO\nexperiment\tO\nset\tO\nup\tO\n2\tO\n:\tO\nwhere\tO\nmemory\tO\nfunction\tO\nwas\tO\nnot\tO\naffected\tO\ni\tO\n.\tO\ne\tO\n.\tO\n7\tO\n-\tO\n9\tO\ndays\tO\nafter\tO\nSTZ\tB-Chemical\ntreatment\tO\n.\tO\n\nThe\tO\nlevel\tO\nof\tO\nGFAP\tO\n,\tO\nCD11b\tO\n,\tO\nTNF\tO\n-\tO\na\tO\n,\tO\nROS\tO\nand\tO\nnitrite\tB-Chemical\nlevels\tO\nwere\tO\nincreased\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\napoptotic\tO\nmarker\tO\n,\tO\nsynaptic\tO\nmarkers\tO\n,\tO\nmitochondrial\tO\nactivity\tO\nand\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nlevels\tO\nremained\tO\nunaffected\tO\n.\tO\n\nCollective\tO\ndata\tO\nindicates\tO\nthat\tO\nneuroinflammatory\tB-Disease\nprocess\tO\nand\tO\noxidative\tO\nstress\tO\noccurs\tO\nearlier\tO\nto\tO\napoptosis\tO\nand\tO\ndoes\tO\nnot\tO\naffect\tO\nmemory\tO\nfunction\tO\n.\tO\n\nPresent\tO\nstudy\tO\nclearly\tO\nsuggests\tO\nthat\tO\nglial\tO\nactivation\tO\nand\tO\npost\tO\nsynaptic\tO\nneurotoxicity\tB-Disease\nare\tO\nthe\tO\nkey\tO\nfactors\tO\nin\tO\nSTZ\tB-Chemical\ninduced\tO\nmemory\tB-Disease\nimpairment\tI-Disease\nand\tO\nneuronal\tO\ncell\tO\ndeath\tO\n.\tO\n\nComparison\tO\nof\tO\neffects\tO\nof\tO\nisotonic\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\nwith\tO\ndiltiazem\tB-Chemical\nin\tO\nprevention\tO\nof\tO\ncontrast\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n.\tO\n\nINTRODUCTION\tO\nAND\tO\nOBJECTIVE\tO\n:\tO\nContrast\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n(\tO\nCIN\tO\n)\tO\nsignificantly\tO\nincreases\tO\nthe\tO\nmorbidity\tO\nand\tO\nmortality\tO\nof\tO\npatients\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nis\tO\nto\tO\ninvestigate\tO\nand\tO\ncompare\tO\nthe\tO\nprotective\tO\neffects\tO\nof\tO\nisotonic\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\nwith\tO\nsodium\tB-Chemical\nbicarbonate\tI-Chemical\ninfusion\tO\nand\tO\nisotonic\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\ninfusion\tO\nwith\tO\ndiltiazem\tB-Chemical\n,\tO\na\tO\ncalcium\tB-Chemical\nchannel\tO\nblocker\tO\n,\tO\nin\tO\npreventing\tO\nCIN\tO\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nOur\tO\nstudy\tO\nincluded\tO\npatients\tO\nwho\tO\nwere\tO\nadministered\tO\n30\tO\n-\tO\n60\tO\nmL\tO\nof\tO\niodinated\tO\ncontrast\tB-Chemical\nagent\tO\nfor\tO\npercutaneous\tO\ncoronary\tO\nangiography\tO\n(\tO\nPCAG\tO\n)\tO\n,\tO\nall\tO\nwith\tO\ncreatinine\tB-Chemical\nvalues\tO\nbetween\tO\n1\tO\n.\tO\n1\tO\nand\tO\n3\tO\n.\tO\n1\tO\nmg\tO\n/\tO\ndL\tO\n.\tO\n\nPatients\tO\nwere\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\nand\tO\neach\tO\ngroup\tO\nhad\tO\n20\tO\npatients\tO\n.\tO\n\nThe\tO\nfirst\tO\ngroup\tO\nof\tO\npatients\tO\nwas\tO\nadministered\tO\nisotonic\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\n;\tO\nthe\tO\nsecond\tO\ngroup\tO\nwas\tO\nadministered\tO\na\tO\nsolution\tO\nthat\tO\nof\tO\n5\tO\n%\tO\ndextrose\tB-Chemical\nand\tO\nsodium\tB-Chemical\nbicarbonate\tI-Chemical\n,\tO\nwhile\tO\nthe\tO\nthird\tO\ngroup\tO\nwas\tO\nadministered\tO\nisotonic\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\nbefore\tO\nand\tO\nafter\tO\nthe\tO\ncontrast\tB-Chemical\ninjection\tO\n.\tO\n\nThe\tO\nthird\tO\ngroup\tO\nreceived\tO\nan\tO\nadditional\tO\ninjection\tO\nof\tO\ndiltiazem\tB-Chemical\nthe\tO\nday\tO\nbefore\tO\nand\tO\nfirst\tO\n2\tO\ndays\tO\nafter\tO\nthe\tO\ncontrast\tB-Chemical\ninjection\tO\n.\tO\n\nAll\tO\nof\tO\nthe\tO\npatients\tO\n'\tO\nplasma\tO\nblood\tB-Chemical\nurea\tI-Chemical\nnitrogen\tI-Chemical\n(\tO\nBUN\tB-Chemical\n)\tO\nand\tO\ncreatinine\tB-Chemical\nlevels\tO\nwere\tO\nmeasured\tO\non\tO\nthe\tO\nsecond\tO\nand\tO\nseventh\tO\nday\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\nintravenous\tO\ncontrast\tB-Chemical\nmaterial\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nbasal\tO\ncreatinine\tB-Chemical\nlevels\tO\nwere\tO\nsimilar\tO\nfor\tO\nall\tO\nthree\tO\ngroups\tO\n(\tO\np\tO\n>\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nAmong\tO\na\tO\ntotal\tO\nof\tO\n60\tO\npatients\tO\nincluded\tO\nin\tO\nthe\tO\nstudy\tO\n,\tO\n16\tO\npatients\tO\ndeveloped\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n(\tO\nARF\tB-Disease\n)\tO\non\tO\nthe\tO\nsecond\tO\nday\tO\nafter\tO\ncontrast\tB-Chemical\nmaterial\tO\nwas\tO\ninjected\tO\n(\tO\n26\tO\n.\tO\n6\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\npatients\tO\nwho\tO\ndeveloped\tO\nARF\tB-Disease\non\tO\nthe\tO\nsecond\tO\nday\tO\nafter\tO\nthe\tO\ninjection\tO\nin\tO\nthe\tO\nfirst\tO\ngroup\tO\nwas\tO\nfive\tO\n(\tO\n25\tO\n%\tO\n)\tO\n,\tO\nin\tO\nthe\tO\nsecond\tO\ngroup\tO\nwas\tO\nsix\tO\n(\tO\n30\tO\n%\tO\n)\tO\nand\tO\nthe\tO\nthird\tO\ngroup\tO\nwas\tO\nfive\tO\n(\tO\n25\tO\n%\tO\n)\tO\n(\tO\np\tO\n>\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThere\tO\nwas\tO\nno\tO\nsignificant\tO\ndifference\tO\nbetween\tO\nisotonic\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\n,\tO\nsodium\tB-Chemical\nbicarbonate\tI-Chemical\nand\tO\nisotonic\tO\nsodium\tB-Chemical\nchloride\tI-Chemical\nwith\tO\ndiltiazem\tB-Chemical\napplication\tO\nin\tO\nprevention\tO\nof\tO\nCIN\tO\n.\tO\n\nNeurocognitive\tO\nand\tO\nneuroradiologic\tO\ncentral\tO\nnervous\tO\nsystem\tO\nlate\tO\neffects\tO\nin\tO\nchildren\tO\ntreated\tO\non\tO\nPediatric\tO\nOncology\tO\nGroup\tO\n(\tO\nPOG\tO\n)\tO\nP9605\tO\n(\tO\nstandard\tO\nrisk\tO\n)\tO\nand\tO\nP9201\tO\n(\tO\nlesser\tO\nrisk\tO\n)\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\nprotocols\tO\n(\tO\nACCL0131\tO\n)\tO\n:\tO\na\tO\nmethotrexate\tB-Chemical\nconsequence\tO\n?\tO\n\nA\tO\nreport\tO\nfrom\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nOncology\tO\nGroup\tO\n.\tO\n\nConcerns\tO\nabout\tO\nlong\tO\n-\tO\nterm\tO\nmethotrexate\tB-Chemical\n(\tO\nMTX\tB-Chemical\n)\tO\nneurotoxicity\tB-Disease\nin\tO\nthe\tO\n1990s\tO\nled\tO\nto\tO\nmodifications\tO\nin\tO\nintrathecal\tO\n(\tO\nIT\tO\n)\tO\ntherapy\tO\n,\tO\nleucovorin\tO\nrescue\tO\n,\tO\nand\tO\nfrequency\tO\nof\tO\nsystemic\tO\nMTX\tB-Chemical\nadministration\tO\nin\tO\nchildren\tO\nwith\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nneurocognitive\tO\noutcomes\tO\nand\tO\nneuroradiologic\tO\nevidence\tO\nof\tO\nleukoencephalopathy\tB-Disease\nwere\tO\ncompared\tO\nin\tO\nchildren\tO\ntreated\tO\nwith\tO\nintense\tO\ncentral\tO\nnervous\tO\nsystem\tO\n(\tO\nCNS\tO\n)\tO\n-\tO\ndirected\tO\ntherapy\tO\n(\tO\nP9605\tO\n)\tO\nversus\tO\nthose\tO\nreceiving\tO\nfewer\tO\nCNS\tO\n-\tO\ndirected\tO\ntreatment\tO\ndays\tO\nduring\tO\nintensive\tO\nconsolidation\tO\n(\tO\nP9201\tO\n)\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n66\tO\nchildren\tO\nfrom\tO\n16\tO\nPediatric\tO\nOncology\tO\nGroup\tO\ninstitutions\tO\nwith\tO\n\"\tO\nstandard\tO\n-\tO\nrisk\tO\n\"\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\n,\tO\n1\tO\n.\tO\n00\tO\nto\tO\n9\tO\n.\tO\n99\tO\nyears\tO\nat\tO\ndiagnosis\tO\n,\tO\nwithout\tO\nevidence\tO\nof\tO\nCNS\tO\nleukemia\tB-Disease\nat\tO\ndiagnosis\tO\nwere\tO\nenrolled\tO\non\tO\nACCL0131\tO\n:\tO\n28\tO\nfrom\tO\nP9201\tO\nand\tO\n38\tO\nfrom\tO\nP9605\tO\n.\tO\n\nMagnetic\tO\nresonance\tO\nimaging\tO\nscans\tO\nand\tO\nstandard\tO\nneuropsychological\tO\ntests\tO\nwere\tO\nperformed\tO\n>\tO\n2\tO\n.\tO\n6\tO\nyears\tO\nafter\tO\nthe\tO\nend\tO\nof\tO\ntreatment\tO\n.\tO\n\nSignificantly\tO\nmore\tO\nP9605\tO\npatients\tO\ndeveloped\tO\nleukoencephalopathy\tB-Disease\ncompared\tO\nwith\tO\nP9201\tO\npatients\tO\n(\tO\n68\tO\n%\tO\n,\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n49\tO\n%\tO\n-\tO\n83\tO\n%\tO\nvs\tO\n.\tO\n22\tO\n%\tO\n,\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n5\tO\n%\tO\n-\tO\n44\tO\n%\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\nidentified\tO\nas\tO\nlate\tO\nas\tO\n7\tO\n.\tO\n7\tO\nyears\tO\nafter\tO\nthe\tO\nend\tO\nof\tO\ntreatment\tO\n.\tO\n\nOverall\tO\n,\tO\n40\tO\n%\tO\nof\tO\npatients\tO\nscored\tO\n<\tO\n85\tO\non\tO\neither\tO\nVerbal\tO\nor\tO\nPerformance\tO\nIQ\tO\n.\tO\n\nChildren\tO\non\tO\nboth\tO\nstudies\tO\nhad\tO\nsignificant\tO\nattention\tB-Disease\nproblems\tI-Disease\n,\tO\nbut\tO\nP9605\tO\nchildren\tO\nscored\tO\nbelow\tO\naverage\tO\non\tO\nmore\tO\nneurocognitive\tO\nmeasures\tO\nthan\tO\nthose\tO\ntreated\tO\non\tO\nP9201\tO\n(\tO\n82\tO\n%\tO\n,\tO\n14\tO\n/\tO\n17\tO\nmeasures\tO\nvs\tO\n.\tO\n24\tO\n%\tO\n,\tO\n4\tO\n/\tO\n17\tO\nmeasures\tO\n)\tO\n.\tO\n\nThis\tO\nsupports\tO\nongoing\tO\nconcerns\tO\nabout\tO\nintensive\tO\nMTX\tB-Chemical\nexposure\tO\nas\tO\na\tO\nmajor\tO\ncontributor\tO\nto\tO\nCNS\tO\nlate\tO\neffects\tO\n.\tO\n\nTranexamic\tB-Chemical\nacid\tI-Chemical\noverdosage\tO\n-\tO\ninduced\tO\ngeneralized\tO\nseizure\tB-Disease\nin\tO\nrenal\tB-Disease\nfailure\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\n45\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nlady\tO\nwith\tO\nchronic\tB-Disease\nkidney\tI-Disease\ndisease\tI-Disease\nstage\tO\n4\tO\ndue\tO\nto\tO\nchronic\tO\ntubulointerstial\tB-Disease\ndisease\tI-Disease\n.\tO\n\nShe\tO\nwas\tO\nadmitted\tO\nto\tO\nour\tO\ncenter\tO\nfor\tO\nsevere\tO\nanemia\tB-Disease\ndue\tO\nto\tO\nmenorrhagia\tB-Disease\nand\tO\ndeterioration\tB-Disease\nof\tI-Disease\nrenal\tI-Disease\nfunction\tI-Disease\n.\tO\n\nShe\tO\nwas\tO\ninfused\tO\nthree\tO\nunits\tO\nof\tO\npacked\tO\ncells\tO\nduring\tO\na\tO\nsession\tO\nof\tO\nhemodialysis\tO\n.\tO\n\nTranexamic\tB-Chemical\nacid\tI-Chemical\n(\tO\nTNA\tB-Chemical\n)\tO\n1\tO\ng\tO\n8\tO\n-\tO\nhourly\tO\nwas\tO\nadministered\tO\nto\tO\nher\tO\nto\tO\ncontrol\tO\nbleeding\tB-Disease\nper\tO\nvaginum\tO\n.\tO\n\nTwo\tO\nhours\tO\nafter\tO\nthe\tO\nsixth\tO\ndose\tO\nof\tO\nTNA\tB-Chemical\n,\tO\nshe\tO\nhad\tO\nan\tO\nepisode\tO\nof\tO\ngeneralized\tO\ntonic\tB-Disease\nclonic\tI-Disease\nconvulsions\tI-Disease\n.\tO\n\nTNA\tB-Chemical\nwas\tO\ndiscontinued\tO\n.\tO\n\nInvestigations\tO\nof\tO\nthe\tO\npatient\tO\nrevealed\tO\nno\tO\nbiochemical\tO\nor\tO\nstructural\tO\ncentral\tO\nnervous\tB-Disease\nsystem\tI-Disease\nabnormalities\tI-Disease\nthat\tO\ncould\tO\nhave\tO\nprovoked\tO\nthe\tO\nconvulsions\tB-Disease\n.\tO\n\nShe\tO\ndid\tO\nnot\tO\nrequire\tO\nany\tO\nfurther\tO\ndialytic\tO\nsupport\tO\n.\tO\n\nShe\tO\nhad\tO\nno\tO\nfurther\tO\nepisodes\tO\nof\tO\nconvulsion\tB-Disease\ntill\tO\ndis\tO\n-\tO\ncharge\tO\nand\tO\nduring\tO\nthe\tO\ntwo\tO\nmonths\tO\nof\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nThus\tO\n,\tO\nthe\tO\nprecipitating\tO\ncause\tO\nof\tO\nconvulsions\tB-Disease\nwas\tO\nbelieved\tO\nto\tO\nbe\tO\nan\tO\noverdose\tB-Disease\nof\tO\nTNA\tB-Chemical\n.\tO\n\nPre\tO\n-\tO\ntreatment\tO\nof\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\ncardiovascular\tB-Disease\ndepression\tI-Disease\nusing\tO\ndifferent\tO\nlipid\tO\nformulations\tO\nof\tO\npropofol\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nPre\tO\n-\tO\ntreatment\tO\nwith\tO\nlipid\tO\nemulsions\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nincrease\tO\nlethal\tO\ndoses\tO\nof\tO\nbupivacaine\tB-Chemical\n,\tO\nand\tO\nthe\tO\nlipid\tO\ncontent\tO\nof\tO\npropofol\tB-Chemical\nmay\tO\nalleviate\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nis\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\npropofol\tB-Chemical\nin\tO\nintralipid\tO\nor\tO\nmedialipid\tO\nemulsions\tO\non\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nRats\tO\nwere\tO\nanaesthetised\tO\nwith\tO\nketamine\tB-Chemical\nand\tO\nwere\tO\ngiven\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\npropofol\tB-Chemical\nin\tO\nintralipid\tO\n(\tO\nGroup\tO\nP\tO\n)\tO\n,\tO\npropofol\tB-Chemical\nin\tO\nmedialipid\tO\n(\tO\nGroup\tO\nL\tO\n)\tO\n,\tO\nor\tO\nsaline\tO\n(\tO\nGroup\tO\nC\tO\n)\tO\nover\tO\n20\tO\nmin\tO\n.\tO\n\nThereafter\tO\n,\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\nbupivacaine\tB-Chemical\n0\tO\n.\tO\n5\tO\n%\tO\nwas\tO\ninfused\tO\n.\tO\n\nWe\tO\nrecorded\tO\ntime\tO\nto\tO\nfirst\tO\ndysrhythmia\tB-Disease\noccurrence\tO\n,\tO\nrespective\tO\ntimes\tO\nto\tO\n25\tO\n%\tO\nand\tO\n50\tO\n%\tO\nreduction\tO\nof\tO\nthe\tO\nheart\tO\nrate\tO\n(\tO\nHR\tO\n)\tO\nand\tO\nmean\tO\narterial\tO\npressure\tO\n,\tO\nand\tO\ntime\tO\nto\tO\nasystole\tB-Disease\nand\tO\ntotal\tO\namount\tO\nof\tO\nbupivacaine\tB-Chemical\nconsumption\tO\n.\tO\n\nBlood\tO\nand\tO\ntissue\tO\nsamples\tO\nwere\tO\ncollected\tO\nfollowing\tO\nasystole\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\ntime\tO\nto\tO\nfirst\tO\ndysrhythmia\tB-Disease\noccurrence\tO\n,\tO\ntime\tO\nto\tO\n25\tO\n%\tO\nand\tO\n50\tO\n%\tO\nreductions\tO\nin\tO\nHR\tO\n,\tO\nand\tO\ntime\tO\nto\tO\nasystole\tB-Disease\nwere\tO\nlonger\tO\nin\tO\nGroup\tO\nP\tO\nthan\tO\nthe\tO\nother\tO\ngroups\tO\n.\tO\n\nThe\tO\ncumulative\tO\nbupivacaine\tB-Chemical\ndose\tO\ngiven\tO\nat\tO\nthose\tO\ntime\tO\npoints\tO\nwas\tO\nhigher\tO\nin\tO\nGroup\tO\nP\tO\n.\tO\nPlasma\tO\nbupivacaine\tB-Chemical\nlevels\tO\nwere\tO\nsignificantly\tO\nlower\tO\nin\tO\nGroup\tO\nP\tO\nthan\tO\nin\tO\nGroup\tO\nC\tO\n.\tO\nBupivacaine\tB-Chemical\nlevels\tO\nin\tO\nthe\tO\nbrain\tO\nand\tO\nheart\tO\nwere\tO\nsignificantly\tO\nlower\tO\nin\tO\nGroup\tO\nP\tO\nand\tO\nGroup\tO\nL\tO\nthan\tO\nin\tO\nGroup\tO\nC\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nWe\tO\nconclude\tO\nthat\tO\npre\tO\n-\tO\ntreatment\tO\nwith\tO\npropofol\tB-Chemical\nin\tO\nintralipid\tO\n,\tO\ncompared\tO\nwith\tO\npropofol\tB-Chemical\nin\tO\nmedialipid\tO\nor\tO\nsaline\tO\n,\tO\ndelayed\tO\nthe\tO\nonset\tO\nof\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxic\tB-Disease\neffects\tO\nas\tO\nwell\tO\nas\tO\nreduced\tO\nplasma\tO\nbupivacaine\tB-Chemical\nlevels\tO\n.\tO\n\nFurther\tO\nstudies\tO\nare\tO\nneeded\tO\nto\tO\nexplore\tO\ntissue\tO\nbupivacaine\tB-Chemical\nlevels\tO\nof\tO\npropofol\tB-Chemical\nin\tO\nmedialipid\tO\nand\tO\nadapt\tO\nthese\tO\nresults\tO\nto\tO\nclinical\tO\npractice\tO\n.\tO\n\nDrug\tB-Disease\n-\tI-Disease\nInduced\tI-Disease\nAcute\tI-Disease\nLiver\tI-Disease\nInjury\tI-Disease\nWithin\tO\n12\tO\nHours\tO\nAfter\tO\nFluvastatin\tB-Chemical\nTherapy\tO\n.\tO\n\nAlthough\tO\nstatins\tB-Chemical\nare\tO\ngenerally\tO\nwell\tO\n-\tO\ntolerated\tO\ndrugs\tO\n,\tO\nrecent\tO\ncases\tO\nof\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nliver\tI-Disease\ninjury\tI-Disease\nassociated\tO\nwith\tO\ntheir\tO\nuse\tO\nhave\tO\nbeen\tO\nreported\tO\n.\tO\n\nA\tO\n52\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nChinese\tO\nman\tO\nreported\tO\nwith\tO\nliver\tB-Disease\ndamage\tI-Disease\n,\tO\nwhich\tO\nappeared\tO\n12\tO\nhours\tO\nafter\tO\nbeginning\tO\ntreatment\tO\nwith\tO\nfluvastatin\tB-Chemical\n.\tO\n\nPatient\tO\npresented\tO\nwith\tO\ncomplaints\tO\nof\tO\nincreasing\tO\nnausea\tB-Disease\n,\tO\nanorexia\tB-Disease\n,\tO\nand\tO\nupper\tO\nabdominal\tB-Disease\npain\tI-Disease\n.\tO\n\nHis\tO\nlaboratory\tO\nvalues\tO\nshowed\tO\nelevated\tO\ncreatine\tB-Chemical\nkinase\tO\nand\tO\ntransaminases\tO\n.\tO\n\nTesting\tO\nfor\tO\nautoantibodies\tO\nwas\tO\nalso\tO\nnegative\tO\n.\tO\n\nThe\tO\nliver\tO\nbiochemistries\tO\neventually\tO\nnormalized\tO\nwithin\tO\n3\tO\nweeks\tO\nof\tO\nstopping\tO\nthe\tO\nfluvastatin\tB-Chemical\n.\tO\n\nTherefore\tO\n,\tO\nwhen\tO\nprescribing\tO\nstatins\tO\n,\tO\nthe\tO\npossibility\tO\nof\tO\nhepatic\tB-Disease\ndamage\tI-Disease\nshould\tO\nbe\tO\ntaken\tO\ninto\tO\naccount\tO\n.\tO\n\nFluconazole\tB-Chemical\nassociated\tO\nagranulocytosis\tB-Disease\nand\tO\nthrombocytopenia\tB-Disease\n.\tO\n\nCASE\tO\n:\tO\nWe\tO\ndescribe\tO\na\tO\nsecond\tO\ncase\tO\nof\tO\nfluconazole\tB-Chemical\nassociated\tO\nagranulocytosis\tB-Disease\nwith\tO\nthrombocytopenia\tB-Disease\nand\tO\nrecovery\tO\nupon\tO\ndiscontinuation\tO\nof\tO\ntherapy\tO\n.\tO\n\nThe\tO\npatient\tO\nbegan\tO\nto\tO\nhave\tO\nchanges\tO\nin\tO\nwhite\tO\nblood\tO\ncells\tO\nand\tO\nplatelets\tO\nwithin\tO\n48\tO\nh\tO\nof\tO\nadministration\tO\nof\tO\nfluconazole\tB-Chemical\nand\tO\nbegan\tO\nto\tO\nrecover\tO\nwith\tO\n48\tO\nh\tO\nof\tO\ndiscontinuation\tO\n.\tO\n\nThis\tO\ncase\tO\nhighlights\tO\nthat\tO\ndrug\tO\n-\tO\ninduced\tO\nblood\tB-Disease\ndyscrasias\tI-Disease\ncan\tO\noccur\tO\nunexpectedly\tO\nas\tO\na\tO\nresult\tO\nof\tO\ntreatment\tO\nwith\tO\na\tO\ncommonly\tO\nused\tO\ndrug\tO\nthought\tO\nto\tO\nbe\tO\n\"\tO\nsafe\tO\n\"\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nAccording\tO\nto\tO\nNaranjo\tO\n'\tO\ns\tO\nalgorithm\tO\nthe\tO\nlikelihood\tO\nthat\tO\nour\tO\npatient\tO\n'\tO\ns\tO\nagranulocytosis\tB-Disease\nand\tO\nthrombocytopenia\tB-Disease\noccurred\tO\nas\tO\na\tO\nresult\tO\nof\tO\ntherapy\tO\nwith\tO\nfluconazole\tB-Chemical\nis\tO\nprobable\tO\n,\tO\nwith\tO\na\tO\ntotal\tO\nof\tO\nsix\tO\npoints\tO\n.\tO\n\nWe\tO\nfeel\tO\nthat\tO\nthe\tO\nweight\tO\nof\tO\nthe\tO\noverall\tO\nevidence\tO\nof\tO\nthis\tO\nevidence\tO\nis\tO\nstrong\tO\n.\tO\n\nIn\tO\nparticular\tO\nthe\tO\ntemporal\tO\nrelationship\tO\nof\tO\nbone\tB-Disease\nmarrow\tI-Disease\nsuppression\tI-Disease\nto\tO\nthe\tO\ninitiation\tO\nof\tO\nfluconazole\tB-Chemical\nand\tO\nthe\tO\nabatement\tO\nof\tO\nsymptoms\tO\nthat\tO\nrapidly\tO\nreversed\tO\nimmediately\tO\nfollowing\tO\ndiscontinuation\tO\n.\tO\n\nTwo\tO\n-\tO\ndimensional\tO\nspeckle\tO\ntracking\tO\nechocardiography\tO\ncombined\tO\nwith\tO\nhigh\tO\n-\tO\nsensitive\tO\ncardiac\tO\ntroponin\tO\nT\tO\nin\tO\nearly\tO\ndetection\tO\nand\tO\nprediction\tO\nof\tO\ncardiotoxicity\tB-Disease\nduring\tO\nepirubicine\tB-Chemical\n-\tO\nbased\tO\nchemotherapy\tO\n.\tO\n\nAIMS\tO\n:\tO\nTo\tO\ninvestigate\tO\nwhether\tO\nalterations\tO\nof\tO\nmyocardial\tB-Disease\nstrain\tI-Disease\nand\tO\nhigh\tO\n-\tO\nsensitive\tO\ncardiac\tO\ntroponin\tO\nT\tO\n(\tO\ncTnT\tO\n)\tO\ncould\tO\npredict\tO\nfuture\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\nin\tO\npatients\tO\nafter\tO\nepirubicin\tB-Chemical\nexposure\tO\n.\tO\n\nMETHODS\tO\n:\tO\nSeventy\tO\n-\tO\nfive\tO\npatients\tO\nwith\tO\nnon\tB-Disease\n-\tI-Disease\nHodgkin\tI-Disease\nlymphoma\tI-Disease\ntreated\tO\nwith\tO\nepirubicin\tB-Chemical\nwere\tO\nstudied\tO\n.\tO\n\nBlood\tO\ncollection\tO\nand\tO\nechocardiography\tO\nwere\tO\nperformed\tO\nat\tO\nbaseline\tO\n,\tO\n1\tO\nday\tO\nafter\tO\nthe\tO\nthird\tO\ncycle\tO\n,\tO\nand\tO\n1\tO\nday\tO\nafter\tO\ncompletion\tO\nof\tO\nchemotherapy\tO\n.\tO\n\nPatients\tO\nwere\tO\nstudied\tO\nusing\tO\nechocardiography\tO\nduring\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nGlobal\tO\nlongitudinal\tO\n(\tO\nGLS\tO\n)\tO\n,\tO\ncircumferential\tO\n(\tO\nGCS\tO\n)\tO\n,\tO\nand\tO\nradial\tO\nstrain\tO\n(\tO\nGRS\tO\n)\tO\nwere\tO\ncalculated\tO\nusing\tO\nspeckle\tO\ntracking\tO\nechocardiography\tO\n.\tO\n\nLeft\tO\nventricular\tO\nejection\tO\nfraction\tO\nwas\tO\nanalysed\tO\nby\tO\nreal\tO\n-\tO\ntime\tO\n3D\tO\nechocardiography\tO\n.\tO\n\nCardiotoxicity\tB-Disease\nwas\tO\ndefined\tO\nas\tO\na\tO\nreduction\tO\nof\tO\nthe\tO\nLVEF\tO\nof\tO\n>\tO\n5\tO\n%\tO\nto\tO\n<\tO\n55\tO\n%\tO\nwith\tO\nsymptoms\tO\nof\tO\nheart\tB-Disease\nfailure\tI-Disease\nor\tO\nan\tO\nasymptomatic\tO\nreduction\tO\nof\tO\nthe\tO\nLVEF\tO\nof\tO\n>\tO\n10\tO\n%\tO\nto\tO\n<\tO\n55\tO\n%\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFourteen\tO\npatients\tO\n(\tO\n18\tO\n.\tO\n67\tO\n%\tO\n)\tO\ndeveloped\tO\ncardiotoxicity\tB-Disease\nafter\tO\ntreatment\tO\n.\tO\n\nGLS\tO\n(\tO\n-\tO\n18\tO\n.\tO\n48\tO\n+\tO\n1\tO\n.\tO\n72\tO\n%\tO\nvs\tO\n.\tO\n-\tO\n15\tO\n.\tO\n96\tO\n+\tO\n1\tO\n.\tO\n6\tO\n%\tO\n)\tO\n,\tO\nGCS\tO\n(\tO\n-\tO\n20\tO\n.\tO\n93\tO\n+\tO\n2\tO\n.\tO\n86\tO\n%\tO\nvs\tO\n.\tO\n-\tO\n19\tO\n.\tO\n20\tO\n+\tO\n3\tO\n.\tO\n21\tO\n%\tO\n)\tO\n,\tO\nand\tO\nGRS\tO\n(\tO\n39\tO\n.\tO\n23\tO\n+\tO\n6\tO\n.\tO\n44\tO\n%\tO\nvs\tO\n.\tO\n34\tO\n.\tO\n98\tO\n+\tO\n6\tO\n.\tO\n2\tO\n%\tO\n)\tO\nwere\tO\nmarkedly\tO\nreduced\tO\nand\tO\ncTnT\tO\nwas\tO\nelevated\tO\nfrom\tO\n0\tO\n.\tO\n0010\tO\n+\tO\n0\tO\n.\tO\n0020\tO\nto\tO\n0\tO\n.\tO\n0073\tO\n+\tO\n0\tO\n.\tO\n0038\tO\nng\tO\n/\tO\nmL\tO\n(\tO\nP\tO\nall\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nat\tO\nthe\tO\ncompletion\tO\nof\tO\nchemotherapy\tO\ncompared\tO\nwith\tO\nbaseline\tO\nvalues\tO\n.\tO\n\nA\tO\n>\tO\n15\tO\n.\tO\n9\tO\n%\tO\ndecrease\tO\nin\tO\nGLS\tO\n[\tO\nsensitivity\tO\n,\tO\n86\tO\n%\tO\n;\tO\nspecificity\tO\n,\tO\n75\tO\n%\tO\n;\tO\narea\tO\nunder\tO\nthe\tO\ncurve\tO\n(\tO\nAUC\tO\n)\tO\n=\tO\n0\tO\n.\tO\n815\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n001\tO\n]\tO\nand\tO\na\tO\n>\tO\n0\tO\n.\tO\n004\tO\nng\tO\n/\tO\nmL\tO\nelevation\tO\nin\tO\ncTnT\tO\n(\tO\nsensitivity\tO\n,\tO\n79\tO\n%\tO\n;\tO\nspecificity\tO\n,\tO\n64\tO\n%\tO\n;\tO\nAUC\tO\n=\tO\n0\tO\n.\tO\n757\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n005\tO\n)\tO\nfrom\tO\nbaseline\tO\nto\tO\nthe\tO\nthird\tO\ncycle\tO\nof\tO\nchemotherapy\tO\npredicted\tO\nlater\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nThe\tO\ndecrease\tO\nin\tO\nGLS\tO\nremained\tO\nthe\tO\nonly\tO\nindependent\tO\npredictor\tO\nof\tO\ncardiotoxicity\tB-Disease\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n000\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nGLS\tO\ncombined\tO\nwith\tO\ncTnT\tO\nmay\tO\nprovide\tO\na\tO\nreliable\tO\nand\tO\nnon\tO\n-\tO\ninvasive\tO\nmethod\tO\nto\tO\npredict\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\nin\tO\npatients\tO\nreceiving\tO\nanthracycline\tB-Chemical\n-\tO\nbased\tO\nchemotherapy\tO\n.\tO\n\nPrevention\tO\nof\tO\netomidate\tB-Chemical\n-\tO\ninduced\tO\nmyoclonus\tB-Disease\n:\tO\nwhich\tO\nis\tO\nsuperior\tO\n:\tO\nFentanyl\tB-Chemical\n,\tO\nmidazolam\tB-Chemical\n,\tO\nor\tO\na\tO\ncombination\tO\n?\tO\n\nA\tO\nRetrospective\tO\ncomparative\tO\nstudy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIn\tO\nthis\tO\nretrospective\tO\ncomparative\tO\nstudy\tO\n,\tO\nwe\tO\naimed\tO\nto\tO\ncompare\tO\nthe\tO\neffectiveness\tO\nof\tO\nfentanyl\tB-Chemical\n,\tO\nmidazolam\tB-Chemical\n,\tO\nand\tO\na\tO\ncombination\tO\nof\tO\nfentanyl\tB-Chemical\nand\tO\nmidazolam\tB-Chemical\nto\tO\nprevent\tO\netomidate\tB-Chemical\n-\tO\ninduced\tO\nmyoclonus\tB-Disease\n.\tO\n\nMATERIAL\tO\nAND\tO\nMETHODS\tO\n:\tO\nThis\tO\nstudy\tO\nwas\tO\nperformed\tO\nbased\tO\non\tO\nanesthesia\tO\nrecords\tO\n.\tO\n\nDepending\tO\non\tO\nthe\tO\ndrugs\tO\nthat\tO\nwould\tO\nbe\tO\ngiven\tO\nbefore\tO\nthe\tO\ninduction\tO\nof\tO\nanesthesia\tO\nwith\tO\netomidate\tB-Chemical\n,\tO\nthe\tO\npatients\tO\nwere\tO\nseparated\tO\ninto\tO\n4\tO\ngroups\tO\n:\tO\nno\tO\npretreatment\tO\n(\tO\nGroup\tO\nNP\tO\n)\tO\n,\tO\nfentanyl\tB-Chemical\n1\tO\nug\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n(\tO\nGroup\tO\nF\tO\n)\tO\n,\tO\nmidazolam\tB-Chemical\n0\tO\n.\tO\n03\tO\nmg\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n(\tO\nGroup\tO\nM\tO\n)\tO\n,\tO\nand\tO\nmidazolam\tB-Chemical\n0\tO\n.\tO\n015\tO\nmg\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n+\tO\nfentanyl\tB-Chemical\n0\tO\n.\tO\n5\tO\nug\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n(\tO\nGroup\tO\nFM\tO\n)\tO\n.\tO\n\nPatients\tO\nwho\tO\nreceived\tO\nthe\tO\nsame\tO\nanesthetic\tO\nprocedure\tO\nwere\tO\nselected\tO\n:\tO\n2\tO\nminutes\tO\nafter\tO\nintravenous\tO\ninjections\tO\nof\tO\nthe\tO\npretreatment\tO\ndrugs\tO\n,\tO\nanesthesia\tO\nis\tO\ninduced\tO\nwith\tO\n0\tO\n.\tO\n3\tO\nmg\tO\n.\tO\nkg\tO\n-\tO\n1\tO\netomidate\tB-Chemical\ninjected\tO\nintravenously\tO\nover\tO\na\tO\nperiod\tO\nof\tO\n20\tO\n-\tO\n30\tO\nseconds\tO\n.\tO\n\nMyoclonic\tB-Disease\nmovements\tI-Disease\nare\tO\nevaluated\tO\n,\tO\nwhich\tO\nwere\tO\nobserved\tO\nand\tO\ngraded\tO\naccording\tO\nto\tO\nclinical\tO\nseverity\tO\nduring\tO\nthe\tO\n2\tO\nminutes\tO\nafter\tO\netomidate\tB-Chemical\ninjection\tO\n.\tO\n\nThe\tO\nseverity\tO\nof\tO\npain\tB-Disease\ndue\tO\nto\tO\netomidate\tB-Chemical\ninjection\tO\n,\tO\nmean\tO\narterial\tO\npressure\tO\n,\tO\nheart\tO\nrate\tO\n,\tO\nand\tO\nadverse\tO\neffects\tO\nwere\tO\nalso\tO\nevaluated\tO\n.\tO\n\nRESULTS\tO\n:\tO\nStudy\tO\nresults\tO\nshowed\tO\nthat\tO\nmyoclonus\tB-Disease\nincidence\tO\nwas\tO\n85\tO\n%\tO\n,\tO\n40\tO\n%\tO\n,\tO\n70\tO\n%\tO\n,\tO\nand\tO\n25\tO\n%\tO\nin\tO\nGroup\tO\nNP\tO\n,\tO\nGroup\tO\nF\tO\n,\tO\nGroup\tO\nM\tO\n,\tO\nand\tO\nGroup\tO\nFM\tO\n,\tO\nrespectively\tO\n,\tO\nand\tO\nwere\tO\nsignificantly\tO\nlower\tO\nin\tO\nGroup\tO\nF\tO\nand\tO\nGroup\tO\nFM\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nconclude\tO\nthat\tO\npretreatment\tO\nwith\tO\nfentanyl\tB-Chemical\nor\tO\ncombination\tO\nof\tO\nfentanyl\tB-Chemical\nand\tO\nmidazolam\tB-Chemical\nwas\tO\neffective\tO\nin\tO\npreventing\tO\netomidate\tB-Chemical\n-\tO\ninduced\tO\nmyoclonus\tB-Disease\n.\tO\n\nConvulsant\tO\neffect\tO\nof\tO\nlindane\tB-Chemical\nand\tO\nregional\tO\nbrain\tO\nconcentration\tO\nof\tO\nGABA\tB-Chemical\nand\tO\ndopamine\tB-Chemical\n.\tO\n\nLindane\tB-Chemical\n(\tO\ngamma\tB-Chemical\n-\tI-Chemical\nhexachlorocyclohexane\tI-Chemical\n)\tO\nis\tO\nan\tO\norganochlorine\tO\ninsecticide\tO\nwith\tO\nknown\tO\nneurotoxic\tB-Disease\neffects\tO\n.\tO\n\nIts\tO\nmechanism\tO\nof\tO\naction\tO\nis\tO\nnot\tO\nwell\tO\nunderstood\tO\nalthough\tO\nit\tO\nhas\tO\nbeen\tO\nproposed\tO\nthat\tO\nlindane\tB-Chemical\nacts\tO\nas\tO\na\tO\nnon\tO\n-\tO\ncompetitive\tO\nantagonist\tO\nat\tO\nthe\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n(\tO\nGABA\tB-Chemical\n)\tO\n-\tO\nA\tO\nreceptor\tO\n.\tO\n\nWe\tO\nstudied\tO\nthe\tO\neffect\tO\nof\tO\nlindane\tB-Chemical\n(\tO\n150\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\non\tO\nthe\tO\nGABAergic\tO\nand\tO\ndopaminergic\tO\nsystems\tO\nby\tO\nmeasuring\tO\nthe\tO\nconcentration\tO\nof\tO\nGABA\tB-Chemical\n,\tO\ndopamine\tB-Chemical\nand\tO\nits\tO\nmetabolites\tO\nin\tO\n7\tO\nbrain\tO\nareas\tO\nat\tO\nthe\tO\nonset\tO\nof\tO\nseizures\tB-Disease\n.\tO\n\nAll\tO\nanimals\tO\nsuffered\tO\ntonic\tO\nconvulsions\tB-Disease\nat\tO\n18\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n4\tO\nmin\tO\nafter\tO\nlindane\tB-Chemical\nadministration\tO\n.\tO\n\nThe\tO\nconcentration\tO\nof\tO\nGABA\tB-Chemical\nwas\tO\nonly\tO\nslightly\tO\nbut\tO\nsignificantly\tO\ndecreased\tO\nin\tO\nthe\tO\ncolliculi\tO\nwithout\tO\nmodifications\tO\nin\tO\nthe\tO\nother\tO\nareas\tO\n.\tO\n\nThe\tO\nconcentration\tO\nof\tO\ndopamine\tB-Chemical\nwas\tO\nincreased\tO\nin\tO\nthe\tO\nmesencephalon\tO\nand\tO\nthat\tO\nof\tO\nits\tO\nmetabolite\tO\nDOPAC\tB-Chemical\nwas\tO\nalso\tO\nincreased\tO\nin\tO\nthe\tO\nmesencephalon\tO\nand\tO\nthe\tO\nstriatum\tO\n.\tO\n\nCholestatic\tB-Disease\npresentation\tO\nof\tO\nyellow\tO\nphosphorus\tB-Chemical\npoisoning\tB-Disease\n.\tO\n\nYellow\tO\nphosphorus\tB-Chemical\n,\tO\na\tO\ncomponent\tO\nof\tO\ncertain\tO\npesticide\tO\npastes\tO\nand\tO\nfireworks\tO\n,\tO\nis\tO\nwell\tO\nknown\tO\nto\tO\ncause\tO\nhepatotoxicity\tB-Disease\n.\tO\n\nPoisoning\tB-Disease\nwith\tO\nyellow\tO\nphosphorus\tB-Chemical\nclassically\tO\nmanifests\tO\nwith\tO\nacute\tB-Disease\nhepatitis\tI-Disease\nleading\tO\nto\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nwhich\tO\nmay\tO\nneed\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\ncase\tO\nof\tO\nyellow\tO\nphosphorus\tB-Chemical\npoisoning\tB-Disease\nin\tO\nwhich\tO\na\tO\npatient\tO\npresented\tO\nwith\tO\nflorid\tO\nclinical\tO\nfeatures\tO\nof\tO\ncholestasis\tB-Disease\nhighlighting\tO\nthe\tO\nfact\tO\nthat\tO\ncholestasis\tB-Disease\ncan\tO\nrarely\tO\nbe\tO\na\tO\npresenting\tO\nfeature\tO\nof\tO\nyellow\tO\nphosphorus\tB-Chemical\nhepatotoxicity\tB-Disease\n.\tO\n\nVasovagal\tB-Disease\nsyncope\tI-Disease\nand\tO\nsevere\tO\nbradycardia\tB-Disease\nfollowing\tO\nintranasal\tO\ndexmedetomidine\tB-Chemical\nfor\tO\npediatric\tO\nprocedural\tO\nsedation\tO\n.\tO\n\nWe\tO\nreport\tO\nsyncope\tB-Disease\nand\tO\nbradycardia\tB-Disease\nin\tO\nan\tO\n11\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ngirl\tO\nfollowing\tO\nadministration\tO\nof\tO\nintranasal\tO\ndexmedetomidine\tB-Chemical\nfor\tO\nsedation\tO\nfor\tO\na\tO\nvoiding\tO\ncystourethrogram\tO\n.\tO\n\nFollowing\tO\nsuccessful\tO\ncompletion\tO\nof\tO\nVCUG\tO\nand\tO\na\tO\n60\tO\n-\tO\nmin\tO\nrecovery\tO\nperiod\tO\n,\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nlevel\tO\nof\tO\nconsciousness\tO\nand\tO\nvital\tO\nsigns\tO\nreturned\tO\nto\tO\npresedation\tO\nlevels\tO\n.\tO\n\nUpon\tO\nleaving\tO\nthe\tO\nsedation\tO\narea\tO\n,\tO\nthe\tO\npatient\tO\ncollapsed\tO\n,\tO\nwith\tO\nno\tO\napparent\tO\ninciting\tO\nevent\tO\n.\tO\n\nThe\tO\npatient\tO\nquickly\tO\nregained\tO\nconsciousness\tO\nand\tO\nno\tO\ninjury\tO\noccurred\tO\n.\tO\n\nThe\tO\nprimary\tO\nabnormality\tO\nfound\tO\nwas\tO\npersistent\tO\nbradycardia\tB-Disease\n,\tO\nand\tO\nshe\tO\nwas\tO\nadmitted\tO\nto\tO\nthe\tO\nhospital\tO\nfor\tO\ntelemetric\tO\nobservation\tO\n.\tO\n\nThe\tO\nbradycardia\tB-Disease\nlasted\tO\n~\tO\n2\tO\nh\tO\n,\tO\nand\tO\nfurther\tO\ncardiac\tO\nworkup\tO\nrevealed\tO\nno\tO\nunderlying\tO\nabnormality\tO\n.\tO\n\nUnanticipated\tO\nand\tO\npreviously\tO\nunreported\tO\noutcomes\tO\nmay\tO\nbe\tO\nwitnessed\tO\nas\tO\nwe\tO\nexpand\tO\nthe\tO\nuse\tO\nof\tO\ncertain\tO\nsedatives\tO\nto\tO\nalternative\tO\nroutes\tO\nof\tO\nadministration\tO\n.\tO\n\nParadoxical\tO\nsevere\tO\nagitation\tB-Disease\ninduced\tO\nby\tO\nadd\tO\n-\tO\non\tO\nhigh\tO\n-\tO\ndoses\tO\nquetiapine\tB-Chemical\nin\tO\nschizo\tB-Disease\n-\tI-Disease\naffective\tI-Disease\ndisorder\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n35\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\nsuffering\tO\nfrom\tO\nschizo\tB-Disease\n-\tI-Disease\naffective\tI-Disease\ndisorder\tI-Disease\nsince\tO\nthe\tO\nage\tO\nof\tO\n19\tO\nyears\tO\n,\tO\ntreated\tO\nby\tO\na\tO\ncombination\tO\nof\tO\nfirst\tO\n-\tO\ngeneration\tO\nantipsychotics\tO\n,\tO\nzuclopenthixol\tB-Chemical\n(\tO\n100\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nand\tO\nlithium\tB-Chemical\n(\tO\n1200\tO\nmg\tO\n/\tO\nday\tO\n)\tO\n(\tO\nserum\tO\nlithium\tB-Chemical\n=\tO\n0\tO\n.\tO\n85\tO\nmEq\tO\n/\tO\nl\tO\n)\tO\n.\tO\n\nThis\tO\npatient\tO\nhad\tO\nno\tO\nassociated\tO\npersonality\tB-Disease\ndisorder\tI-Disease\n(\tO\nparticularly\tO\nno\tO\nantisocial\tB-Disease\ndisorder\tI-Disease\n)\tO\nand\tO\nno\tO\nsubstance\tB-Disease\nabuse\tI-Disease\ndisorder\tI-Disease\n.\tO\n\nWithin\tO\nthe\tO\n48\tO\nh\tO\nfollowing\tO\nthe\tO\ngradual\tO\nintroduction\tO\nof\tO\nquetiapine\tB-Chemical\n(\tO\nup\tO\nto\tO\n600\tO\nmg\tO\n/\tO\nday\tO\n)\tO\n,\tO\nthe\tO\npatient\tO\npresented\tO\nsevere\tO\nagitation\tB-Disease\nwithout\tO\nan\tO\nenvironmental\tO\nexplanation\tO\n,\tO\ncontrasting\tO\nwith\tO\nthe\tO\nabsence\tO\nof\tO\na\tO\nhistory\tO\nof\tO\naggressiveness\tB-Disease\nor\tO\npersonality\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nThe\tO\ndiagnoses\tO\nof\tO\nmanic\tB-Disease\nshift\tO\nand\tO\nakathisia\tB-Disease\nwere\tO\ndismissed\tO\n.\tO\n\nThe\tO\nwithdrawal\tO\nand\tO\nthe\tO\ngradual\tO\nreintroduction\tO\nof\tO\nquetiapine\tB-Chemical\n2\tO\nweeks\tO\nlater\tO\n,\tO\nwhich\tO\nled\tO\nto\tO\nanother\tO\nsevere\tO\nagitation\tB-Disease\n,\tO\nenabled\tO\nus\tO\nto\tO\nattribute\tO\nthe\tO\nagitation\tB-Disease\nspecifically\tO\nto\tO\nquetiapine\tB-Chemical\n.\tO\n\nAntioxidant\tO\neffects\tO\nof\tO\nbovine\tO\nlactoferrin\tO\non\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nrat\tO\n.\tO\n\nDexamethasone\tB-Chemical\n-\tO\n(\tO\nDex\tB-Chemical\n-\tO\n)\tO\ninduced\tO\nhypertension\tB-Disease\nis\tO\nassociated\tO\nwith\tO\nenhanced\tO\noxidative\tO\nstress\tO\n.\tO\n\nLactoferrin\tO\n(\tO\nLF\tO\n)\tO\nis\tO\nan\tO\niron\tB-Chemical\n-\tO\nbinding\tO\nglycoprotein\tO\nwith\tO\nantihypertensive\tO\nproperties\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\neffect\tO\nof\tO\nchronic\tO\nadministration\tO\nof\tO\nLF\tO\non\tO\noxidative\tO\nstress\tO\nand\tO\nhypertension\tB-Disease\nupon\tO\nDex\tB-Chemical\nadministration\tO\n.\tO\n\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\ntreated\tO\nby\tO\nDex\tB-Chemical\n(\tO\n30\tO\nu\tO\ng\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nsubcutaneously\tO\n)\tO\nor\tO\nsaline\tO\nfor\tO\n14\tO\ndays\tO\n.\tO\n\nOral\tO\nbovine\tO\nLF\tO\n(\tO\n30\tO\n,\tO\n100\tO\n,\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ngiven\tO\nfrom\tO\nday\tO\n8\tO\nto\tO\n14\tO\nin\tO\na\tO\nreversal\tO\nstudy\tO\n.\tO\n\nIn\tO\na\tO\nprevention\tO\nstudy\tO\n,\tO\nrats\tO\nreceived\tO\n4\tO\ndays\tO\nof\tO\nLF\tO\ntreatment\tO\nfollowed\tO\nby\tO\nDex\tB-Chemical\nand\tO\ncontinued\tO\nduring\tO\nthe\tO\ntest\tO\nperiod\tO\n.\tO\n\nSystolic\tO\nblood\tO\npressure\tO\n(\tO\nSBP\tO\n)\tO\nwas\tO\nmeasured\tO\nusing\tO\ntail\tO\n-\tO\ncuff\tO\nmethod\tO\n.\tO\n\nThymus\tO\nweight\tO\nwas\tO\nused\tO\nas\tO\na\tO\nmarker\tO\nof\tO\nglucocorticoid\tO\nactivity\tO\n.\tO\n\nPlasma\tO\nhydrogen\tB-Chemical\nperoxide\tI-Chemical\n(\tO\nH2O2\tB-Chemical\n)\tO\nconcentration\tO\nand\tO\nferric\tO\nreducing\tO\nantioxidant\tO\npower\tO\n(\tO\nFRAP\tO\n)\tO\nvalue\tO\nwere\tO\ndetermined\tO\n.\tO\n\nDexamethasone\tB-Chemical\nsignificantly\tO\nincreased\tO\nSBP\tO\nand\tO\nplasma\tO\nH2O2\tB-Chemical\nlevel\tO\nand\tO\ndecreased\tO\nthymus\tO\nand\tO\nbody\tO\nweights\tO\n.\tO\n\nLF\tO\nlowered\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nand\tO\ndose\tO\ndependently\tO\nprevented\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nDex\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n.\tO\n\nLF\tO\nprevented\tO\nbody\tO\nweight\tB-Disease\nloss\tI-Disease\nand\tO\nsignificantly\tO\nreduced\tO\nthe\tO\nelevated\tO\nplasma\tO\nH2O2\tB-Chemical\nand\tO\nincreased\tO\nFRAP\tO\nvalues\tO\n.\tO\n\nChronic\tO\nadministration\tO\nof\tO\nLF\tO\nstrongly\tO\nreduced\tO\nthe\tO\nblood\tO\npressure\tO\nand\tO\nproduction\tO\nof\tO\nROS\tO\nand\tO\nimproved\tO\nantioxidant\tO\ncapacity\tO\nin\tO\nDex\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n,\tO\nsuggesting\tO\nthe\tO\nrole\tO\nof\tO\ninhibition\tO\nof\tO\noxidative\tO\nstress\tO\nas\tO\nanother\tO\nmechanism\tO\nof\tO\nantihypertensive\tO\naction\tO\nof\tO\nLF\tO\n.\tO\n\nThe\tO\nassociation\tO\nbetween\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\nand\tO\nconvulsive\tB-Disease\nseizures\tB-Disease\nafter\tO\ncardiac\tO\nsurgery\tO\n:\tO\na\tO\nmultivariate\tO\nanalysis\tO\nin\tO\n11\tO\n529\tO\npatients\tO\n.\tO\n\nBecause\tO\nof\tO\na\tO\nlack\tO\nof\tO\ncontemporary\tO\ndata\tO\nregarding\tO\nseizures\tB-Disease\nafter\tO\ncardiac\tO\nsurgery\tO\n,\tO\nwe\tO\nundertook\tO\na\tO\nretrospective\tO\nanalysis\tO\nof\tO\nprospectively\tO\ncollected\tO\ndata\tO\nfrom\tO\n11\tO\n529\tO\npatients\tO\nin\tO\nwhom\tO\ncardiopulmonary\tO\nbypass\tO\nwas\tO\nused\tO\nfrom\tO\nJanuary\tO\n2004\tO\nto\tO\nDecember\tO\n2010\tO\n.\tO\n\nA\tO\nconvulsive\tB-Disease\nseizure\tB-Disease\nwas\tO\ndefined\tO\nas\tO\na\tO\ntransient\tO\nepisode\tO\nof\tO\ndisturbed\tO\nbrain\tO\nfunction\tO\ncharacterised\tO\nby\tO\nabnormal\tB-Disease\ninvoluntary\tI-Disease\nmotor\tI-Disease\nmovements\tI-Disease\n.\tO\n\nMultivariate\tO\nregression\tO\nanalysis\tO\nwas\tO\nperformed\tO\nto\tO\nidentify\tO\nindependent\tO\npredictors\tO\nof\tO\npostoperative\tO\nseizures\tB-Disease\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n100\tO\n(\tO\n0\tO\n.\tO\n9\tO\n%\tO\n)\tO\npatients\tO\ndeveloped\tO\npostoperative\tO\nconvulsive\tB-Disease\nseizures\tB-Disease\n.\tO\n\nGeneralised\tB-Disease\nand\tI-Disease\nfocal\tI-Disease\nseizures\tI-Disease\nwere\tO\nidentified\tO\nin\tO\n68\tO\nand\tO\n32\tO\npatients\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nmedian\tO\n(\tO\nIQR\tO\n[\tO\nrange\tO\n]\tO\n)\tO\ntime\tO\nafter\tO\nsurgery\tO\nwhen\tO\nthe\tO\nseizure\tB-Disease\noccurred\tO\nwas\tO\n7\tO\n(\tO\n6\tO\n-\tO\n12\tO\n[\tO\n1\tO\n-\tO\n216\tO\n]\tO\n)\tO\nh\tO\nand\tO\n8\tO\n(\tO\n6\tO\n-\tO\n11\tO\n[\tO\n4\tO\n-\tO\n18\tO\n]\tO\n)\tO\nh\tO\n,\tO\nrespectively\tO\n.\tO\n\nEpileptiform\tO\nfindings\tO\non\tO\nelectroencephalography\tO\nwere\tO\nseen\tO\nin\tO\n19\tO\npatients\tO\n.\tO\n\nIndependent\tO\npredictors\tO\nof\tO\npostoperative\tO\nseizures\tB-Disease\nincluded\tO\nage\tO\n,\tO\nfemale\tO\nsex\tO\n,\tO\nredo\tO\ncardiac\tO\nsurgery\tO\n,\tO\ncalcification\tO\nof\tO\nascending\tO\naorta\tO\n,\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n,\tO\ndeep\tO\nhypothermic\tB-Disease\ncirculatory\tO\narrest\tO\n,\tO\nduration\tO\nof\tO\naortic\tO\ncross\tO\n-\tO\nclamp\tO\nand\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nWhen\tO\ntested\tO\nin\tO\na\tO\nmultivariate\tO\nregression\tO\nanalysis\tO\n,\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\nwas\tO\na\tO\nstrong\tO\nindependent\tO\npredictor\tO\nof\tO\nseizures\tB-Disease\n(\tO\nOR\tO\n14\tO\n.\tO\n3\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n5\tO\n.\tO\n5\tO\n-\tO\n36\tO\n.\tO\n7\tO\n;\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nPatients\tO\nwith\tO\nconvulsive\tB-Disease\nseizures\tB-Disease\nhad\tO\n2\tO\n.\tO\n5\tO\ntimes\tO\nhigher\tO\nin\tO\n-\tO\nhospital\tO\nmortality\tO\nrates\tO\nand\tO\ntwice\tO\nthe\tO\nlength\tO\nof\tO\nhospital\tO\nstay\tO\ncompared\tO\nwith\tO\npatients\tO\nwithout\tO\nconvulsive\tB-Disease\nseizures\tB-Disease\n.\tO\n\nMean\tO\n(\tO\nIQR\tO\n[\tO\nrange\tO\n]\tO\n)\tO\nlength\tO\nof\tO\nstay\tO\nin\tO\nthe\tO\nintensive\tO\ncare\tO\nunit\tO\nwas\tO\n115\tO\n(\tO\n49\tO\n-\tO\n228\tO\n[\tO\n32\tO\n-\tO\n481\tO\n]\tO\n)\tO\nh\tO\nin\tO\npatients\tO\nwith\tO\nconvulsive\tB-Disease\nseizures\tB-Disease\ncompared\tO\nwith\tO\n26\tO\n(\tO\n22\tO\n-\tO\n69\tO\n[\tO\n14\tO\n-\tO\n1080\tO\n]\tO\n)\tO\nh\tO\nin\tO\npatients\tO\nwithout\tO\nseizures\tB-Disease\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nConvulsive\tB-Disease\nseizures\tB-Disease\nare\tO\na\tO\nserious\tO\npostoperative\tB-Disease\ncomplication\tI-Disease\nafter\tO\ncardiac\tO\nsurgery\tO\n.\tO\n\nAs\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\nis\tO\nthe\tO\nonly\tO\nmodifiable\tO\nfactor\tO\n,\tO\nits\tO\nadministration\tO\n,\tO\nparticularly\tO\nin\tO\ndoses\tO\nexceeding\tO\n80\tO\nmg\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n,\tO\nshould\tO\nbe\tO\nweighed\tO\nagainst\tO\nthe\tO\nrisk\tO\nof\tO\npostoperative\tO\nseizures\tB-Disease\n.\tO\n\nDysfunctional\tB-Disease\novernight\tI-Disease\nmemory\tI-Disease\nconsolidation\tO\nin\tO\necstasy\tB-Chemical\nusers\tO\n.\tO\n\nSleep\tO\nplays\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\nconsolidation\tO\nand\tO\nintegration\tO\nof\tO\nmemory\tO\nin\tO\na\tO\nprocess\tO\ncalled\tO\novernight\tO\nmemory\tO\nconsolidation\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nindicate\tO\nthat\tO\necstasy\tB-Chemical\nusers\tO\nhave\tO\nmarked\tO\nand\tO\npersistent\tO\nneurocognitive\tO\nand\tO\nsleep\tB-Disease\n-\tI-Disease\nrelated\tI-Disease\nimpairments\tI-Disease\n.\tO\n\nWe\tO\nextend\tO\npast\tO\nresearch\tO\nby\tO\nexamining\tO\novernight\tO\nmemory\tO\nconsolidation\tO\namong\tO\nregular\tO\necstasy\tB-Chemical\nusers\tO\n(\tO\nn\tO\n=\tO\n12\tO\n)\tO\nand\tO\ndrug\tO\nnaive\tO\nhealthy\tO\ncontrols\tO\n(\tO\nn\tO\n=\tO\n26\tO\n)\tO\n.\tO\n\nMemory\tO\nrecall\tO\nof\tO\nword\tO\npairs\tO\nwas\tO\nevaluated\tO\nbefore\tO\nand\tO\nafter\tO\na\tO\nperiod\tO\nof\tO\nsleep\tO\n,\tO\nwith\tO\nand\tO\nwithout\tO\ninterference\tO\nprior\tO\nto\tO\ntesting\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nwe\tO\nassessed\tO\nneurocognitive\tO\nperformances\tO\nacross\tO\ntasks\tO\nof\tO\nlearning\tO\n,\tO\nmemory\tO\nand\tO\nexecutive\tO\nfunctioning\tO\n.\tO\n\nEcstasy\tB-Chemical\nusers\tO\ndemonstrated\tO\nimpaired\tB-Disease\novernight\tI-Disease\nmemory\tI-Disease\nconsolidation\tO\n,\tO\na\tO\nfinding\tO\nthat\tO\nwas\tO\nmore\tO\npronounced\tO\nfollowing\tO\nassociative\tO\ninterference\tO\n.\tO\n\nAdditionally\tO\n,\tO\necstasy\tB-Chemical\nusers\tO\ndemonstrated\tO\nimpairments\tO\non\tO\ntasks\tO\nrecruiting\tO\nfrontostriatal\tO\nand\tO\nhippocampal\tO\nneural\tO\ncircuitry\tO\n,\tO\nin\tO\nthe\tO\ndomains\tO\nof\tO\nproactive\tO\ninterference\tO\nmemory\tO\n,\tO\nlong\tO\n-\tO\nterm\tO\nmemory\tO\n,\tO\nencoding\tO\n,\tO\nworking\tO\nmemory\tO\nand\tO\ncomplex\tO\nplanning\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\necstasy\tB-Chemical\n-\tO\nassociated\tO\ndysfunction\tO\nin\tO\nfronto\tO\n-\tO\ntemporal\tO\ncircuitry\tO\nmay\tO\nunderlie\tO\novernight\tO\nconsolidation\tO\nmemory\tB-Disease\nimpairments\tI-Disease\nin\tO\nregular\tO\necstasy\tB-Chemical\nusers\tO\n.\tO\n\nNormoammonemic\tO\nencephalopathy\tB-Disease\n:\tO\nsolely\tO\nvalproate\tB-Chemical\ninduced\tO\nor\tO\nmultiple\tO\nmechanisms\tO\n?\tO\n\nA\tO\n77\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\npresented\tO\nwith\tO\nsubacute\tO\nonset\tO\nprogressive\tO\nconfusion\tB-Disease\n,\tO\naggression\tB-Disease\n,\tO\nauditory\tB-Disease\nhallucinations\tI-Disease\nand\tO\ndelusions\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\npreceding\tO\nmonths\tO\n,\tO\nthe\tO\npatient\tO\nhad\tO\na\tO\nnumber\tO\nof\tO\nadmissions\tO\nwith\tO\ntransient\tO\nunilateral\tO\nhemiparesis\tB-Disease\nwith\tO\nfacial\tO\ndroop\tO\n,\tO\nand\tO\nhad\tO\nbeen\tO\nstarted\tO\non\tO\nvalproate\tB-Chemical\nfor\tO\npresumed\tO\nhemiplegic\tB-Disease\nmigraine\tI-Disease\n.\tO\n\nValproate\tB-Chemical\nwas\tO\nwithdrawn\tO\nsoon\tO\nafter\tO\nadmission\tO\nand\tO\nher\tO\ncognitive\tO\nabilities\tO\nhave\tO\ngradually\tO\nimproved\tO\nover\tO\n3\tO\nmonths\tO\nof\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nValproate\tB-Chemical\nlevels\tO\ntaken\tO\nprior\tO\nto\tO\nwithdrawal\tO\nwere\tO\nsubtherapeutic\tO\nand\tO\nthe\tO\npatient\tO\nwas\tO\nnormoammonaemic\tO\n.\tO\n\nEEG\tO\nundertaken\tO\nduring\tO\ninpatient\tO\nstay\tO\nshowed\tO\nchanges\tO\nconsistent\tO\nwith\tO\nencephalopathy\tB-Disease\n,\tO\nand\tO\nlow\tO\ntitre\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nreceptor\tO\nantibodies\tO\nwere\tO\npresent\tO\nin\tO\nthis\tO\npatient\tO\n.\tO\n\nThe\tO\npossible\tO\naetiologies\tO\nof\tO\nvalproate\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\nand\tO\nNMDA\tB-Chemical\nreceptor\tO\n-\tO\nassociated\tO\nencephalitis\tB-Disease\npresent\tO\na\tO\ndiagnostic\tO\ndilemma\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\nputative\tO\ncombinatorial\tO\nhypothesis\tO\nto\tO\nexplain\tO\nthis\tO\npatient\tO\n'\tO\ns\tO\nsymptoms\tO\n.\tO\n\nCerebellar\tB-Disease\nand\tI-Disease\noculomotor\tI-Disease\ndysfunction\tI-Disease\ninduced\tO\nby\tO\nrapid\tO\ninfusion\tO\nof\tO\npethidine\tB-Chemical\n.\tO\n\nPethidine\tB-Chemical\nis\tO\nan\tO\nopioid\tO\nthat\tO\ngains\tO\nits\tO\npopularity\tO\nfor\tO\nthe\tO\neffective\tO\npain\tB-Disease\ncontrol\tO\nthrough\tO\nacting\tO\non\tO\nthe\tO\nopioid\tO\n-\tO\nreceptors\tO\n.\tO\n\nHowever\tO\n,\tO\nrapid\tO\npain\tB-Disease\nrelief\tO\nsometimes\tO\nbrings\tO\nabout\tO\nunfavourable\tO\nside\tO\neffects\tO\nthat\tO\nlargely\tO\nlimit\tO\nits\tO\nclinical\tO\nutility\tO\n.\tO\n\nCommon\tO\nside\tO\neffects\tO\ninclude\tO\nnausea\tB-Disease\n,\tO\nvomiting\tB-Disease\nand\tO\nhypotension\tB-Disease\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\nimpaired\tB-Disease\nrenal\tI-Disease\nand\tI-Disease\nliver\tI-Disease\nfunction\tI-Disease\n,\tO\nand\tO\nthose\tO\nwho\tO\nneed\tO\nlong\tO\n-\tO\nterm\tO\npain\tB-Disease\ncontrol\tO\n,\tO\npethidine\tB-Chemical\nmay\tO\ncause\tO\nexcitatory\tO\ncentral\tO\nnervous\tO\nsystem\tO\n(\tO\nCNS\tO\n)\tO\neffects\tO\nthrough\tO\nits\tO\nneurotoxic\tB-Disease\nmetabolite\tO\n,\tO\nnorpethidine\tB-Chemical\n,\tO\nresulting\tO\nin\tO\nirritability\tB-Disease\nand\tO\nseizure\tB-Disease\nattack\tO\n.\tO\n\nOn\tO\nthe\tO\ncontrary\tO\n,\tO\nthough\tO\nnot\tO\nclinically\tO\napparent\tO\n,\tO\npethidine\tB-Chemical\npotentially\tO\ncauses\tO\ninhibitory\tO\nimpacts\tO\non\tO\nthe\tO\nCNS\tO\nand\tO\nimpairs\tO\nnormal\tO\ncerebellar\tO\nand\tO\noculomotor\tO\nfunction\tO\nin\tO\nthe\tO\nshort\tO\nterm\tO\n.\tO\n\nIn\tO\nthis\tO\ncase\tO\nreport\tO\n,\tO\nwe\tO\nhighlight\tO\nopioid\tO\n'\tO\ns\tO\ninhibitory\tO\nside\tO\neffects\tO\non\tO\nthe\tO\ncerebellar\tO\nstructure\tO\nthat\tO\ncauses\tO\ndysmetria\tB-Disease\n,\tO\ndysarthria\tB-Disease\n,\tO\nreduced\tO\nsmooth\tO\npursuit\tO\ngain\tO\nand\tO\ndecreased\tO\nsaccadic\tO\nvelocity\tO\n.\tO\n\nBaboon\tB-Disease\nsyndrome\tI-Disease\ninduced\tO\nby\tO\nketoconazole\tB-Chemical\n.\tO\n\nA\tO\n27\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\npatient\tO\npresented\tO\nwith\tO\na\tO\nmaculopapular\tB-Disease\neruption\tI-Disease\non\tO\nthe\tO\nflexural\tO\nareas\tO\nand\tO\nbuttocks\tO\nafter\tO\nusing\tO\noral\tO\nketoconazole\tB-Chemical\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\ndiagnosed\tO\nwith\tO\ndrug\tO\n-\tO\ninduced\tO\nbaboon\tB-Disease\nsyndrome\tI-Disease\nbased\tO\non\tO\nhis\tO\nhistory\tO\n,\tO\nwhich\tO\nincluded\tO\nprior\tO\nsensitivity\tO\nto\tO\ntopical\tO\nketoconazole\tB-Chemical\n,\tO\na\tO\nphysical\tO\nexamination\tO\n,\tO\nand\tO\nhistopathological\tO\nfindings\tO\n.\tO\n\nBaboon\tB-Disease\nsyndrome\tI-Disease\nis\tO\na\tO\ndrug\tO\n-\tO\nor\tO\ncontact\tO\nallergen\tO\n-\tO\nrelated\tO\nmaculopapular\tB-Disease\neruption\tI-Disease\nthat\tO\ntypically\tO\ninvolves\tO\nthe\tO\nflexural\tO\nand\tO\ngluteal\tO\nareas\tO\n.\tO\n\nTo\tO\nthe\tO\nbest\tO\nof\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\nreported\tO\ncase\tO\nof\tO\nketoconazole\tB-Chemical\n-\tO\ninduced\tO\nbaboon\tB-Disease\nsyndrome\tI-Disease\nin\tO\nthe\tO\nEnglish\tO\nliterature\tO\n.\tO\n\nA\tO\nCase\tO\nof\tO\nSudden\tB-Disease\nCardiac\tI-Disease\nDeath\tI-Disease\ndue\tO\nto\tO\nPilsicainide\tB-Chemical\n-\tO\nInduced\tO\nTorsades\tB-Disease\nde\tI-Disease\nPointes\tI-Disease\n.\tO\n\nAn\tO\n84\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\nreceived\tO\noral\tO\npilsicainide\tB-Chemical\n,\tO\na\tO\npure\tO\nsodium\tB-Chemical\nchannel\tO\nblocker\tO\nwith\tO\nslow\tO\nrecovery\tO\nkinetics\tO\n,\tO\nto\tO\nconvert\tO\nhis\tO\nparoxysmal\tO\natrial\tB-Disease\nfibrillation\tI-Disease\nto\tO\na\tO\nsinus\tO\nrhythm\tO\n;\tO\nthe\tO\npatient\tO\ndeveloped\tO\nsudden\tB-Disease\ncardiac\tI-Disease\ndeath\tI-Disease\ntwo\tO\ndays\tO\nlater\tO\n.\tO\n\nThe\tO\nHolter\tO\nelectrocardiogram\tO\n,\tO\nwhich\tO\nwas\tO\nworn\tO\nby\tO\nchance\tO\n,\tO\nrevealed\tO\ntorsade\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nwith\tO\ngradually\tO\nprolonged\tO\nQT\tO\nintervals\tO\n.\tO\n\nThis\tO\ndrug\tO\nis\tO\nrapidly\tO\nabsorbed\tO\nfrom\tO\nthe\tO\ngastrointestinal\tO\ntract\tO\n,\tO\nand\tO\nmost\tO\nof\tO\nit\tO\nis\tO\nexcreted\tO\nfrom\tO\nthe\tO\nkidney\tO\n.\tO\n\nAlthough\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nrenal\tO\nfunction\tO\nwas\tO\nnot\tO\nhighly\tO\nimpaired\tO\nand\tO\nthe\tO\ndose\tO\nof\tO\npilsicainide\tB-Chemical\nwas\tO\nlow\tO\n,\tO\nthe\tO\nplasma\tO\nconcentration\tO\nof\tO\npilsicainide\tB-Chemical\nmay\tO\nhave\tO\nbeen\tO\nhigh\tO\n,\tO\nwhich\tO\ncan\tO\nproduce\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nin\tO\nthe\tO\noctogenarian\tO\n.\tO\n\nAlthough\tO\nthe\tO\noral\tO\nadministration\tO\nof\tO\nclass\tO\nIC\tO\ndrugs\tO\n,\tO\nincluding\tO\npilsicainide\tB-Chemical\n,\tO\nis\tO\neffective\tO\nto\tO\nterminate\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n,\tO\ncareful\tO\nconsideration\tO\nmust\tO\nbe\tO\ntaken\tO\nbefore\tO\ngiving\tO\nthese\tO\ndrugs\tO\nto\tO\noctogenarians\tO\n.\tO\n\nAll\tB-Chemical\n-\tI-Chemical\ntrans\tI-Chemical\nretinoic\tI-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\ninflammatory\tO\nmyositis\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nacute\tB-Disease\npromyelocytic\tI-Disease\nleukemia\tI-Disease\n.\tO\n\nAll\tB-Chemical\n-\tI-Chemical\ntrans\tI-Chemical\nretinoic\tI-Chemical\nacid\tI-Chemical\n(\tO\nATRA\tB-Chemical\n)\tO\n,\tO\na\tO\ncomponent\tO\nof\tO\nstandard\tO\ntherapy\tO\nfor\tO\nacute\tB-Disease\npromyelocytic\tI-Disease\nleukemia\tI-Disease\n(\tO\nAPL\tB-Disease\n)\tO\n,\tO\nis\tO\nassociated\tO\nwith\tO\npotentially\tO\nserious\tO\nbut\tO\ntreatable\tO\nadverse\tO\neffects\tO\ninvolving\tO\nnumerous\tO\norgan\tO\nsystems\tO\n,\tO\nincluding\tO\nrare\tO\nskeletal\tO\nmuscle\tO\ninvolvement\tO\n.\tO\n\nOnly\tO\na\tO\nhandful\tO\nof\tO\ncases\tO\nof\tO\nATRA\tB-Chemical\n-\tO\ninduced\tO\nmyositis\tB-Disease\nin\tO\nchildren\tO\nhave\tO\nbeen\tO\nreported\tO\n,\tO\nand\tO\nnone\tO\nin\tO\nthe\tO\nradiology\tO\nliterature\tO\n.\tO\n\nWe\tO\npresent\tO\nsuch\tO\na\tO\ncase\tO\nin\tO\na\tO\n15\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwith\tO\nAPL\tB-Disease\n,\tO\nwhere\tO\nrecognition\tO\nof\tO\nimaging\tO\nfindings\tO\nplayed\tO\na\tO\ncrucial\tO\nrole\tO\nin\tO\nmaking\tO\nthe\tO\ndiagnosis\tO\nand\tO\nfacilitated\tO\nprompt\tO\n,\tO\neffective\tO\ntreatment\tO\n.\tO\n\nTolerability\tO\nof\tO\nlomustine\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\ncyclophosphamide\tB-Chemical\nin\tO\ndogs\tO\nwith\tO\nlymphoma\tB-Disease\n.\tO\n\nThis\tO\nretrospective\tO\nstudy\tO\ndescribes\tO\ntoxicity\tB-Disease\nassociated\tO\nwith\tO\na\tO\nprotocol\tO\nof\tO\nlomustine\tB-Chemical\n(\tO\nCCNU\tB-Chemical\n)\tO\nand\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCTX\tB-Chemical\n)\tO\nin\tO\ndogs\tO\nwith\tO\nlymphoma\tB-Disease\n.\tO\n\nCCNU\tB-Chemical\nwas\tO\nadministered\tO\nper\tO\nos\tO\n(\tO\nPO\tO\n)\tO\nat\tO\na\tO\ntargeted\tO\ndosage\tO\nof\tO\n60\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nbody\tO\nsurface\tO\narea\tO\non\tO\nday\tO\n0\tO\n,\tO\nCTX\tB-Chemical\nwas\tO\nadministered\tO\nPO\tO\nat\tO\na\tO\ntargeted\tO\ndosage\tO\nof\tO\n250\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ndivided\tO\nover\tO\ndays\tO\n0\tO\nthrough\tO\n4\tO\n,\tO\nand\tO\nall\tO\ndogs\tO\nreceived\tO\nprophylactic\tO\nantibiotics\tO\n.\tO\n\nNinety\tO\ntreatments\tO\nwere\tO\ngiven\tO\nto\tO\nthe\tO\n57\tO\ndogs\tO\nincluded\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nNeutropenia\tB-Disease\nwas\tO\nthe\tO\nprincipal\tO\ntoxic\tO\neffect\tO\n,\tO\nand\tO\nthe\tO\noverall\tO\nfrequency\tO\nof\tO\ngrade\tO\n4\tO\nneutropenia\tB-Disease\nafter\tO\nthe\tO\nfirst\tO\ntreatment\tO\nof\tO\nCCNU\tB-Chemical\n/\tO\nCTX\tB-Chemical\nwas\tO\n30\tO\n%\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n19\tO\n-\tO\n43\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nbody\tO\nweight\tO\nof\tO\ndogs\tO\nwith\tO\ngrade\tO\n4\tO\nneutropenia\tB-Disease\n(\tO\n19\tO\n.\tO\n7\tO\nkg\tO\n+\tO\n13\tO\n.\tO\n4\tO\nkg\tO\n)\tO\nwas\tO\nsignificantly\tO\nless\tO\nthan\tO\nthe\tO\nmean\tO\nbody\tO\nweight\tO\nof\tO\ndogs\tO\nthat\tO\ndid\tO\nnot\tO\ndevelop\tO\ngrade\tO\n4\tO\nneutropenia\tB-Disease\n(\tO\n31\tO\n.\tO\n7\tO\nkg\tO\n+\tO\n12\tO\n.\tO\n4\tO\nkg\tO\n;\tO\nP\tO\n=\tO\n.\tO\n005\tO\n)\tO\n.\tO\n\nOne\tO\ndog\tO\n(\tO\n3\tO\n%\tO\n)\tO\ndeveloped\tO\nhematologic\tO\nchanges\tO\nsuggestive\tO\nof\tO\nhepatotoxicity\tB-Disease\n.\tO\n\nNo\tO\ndogs\tO\nhad\tO\nevidence\tO\nof\tO\neither\tO\nrenal\tB-Disease\ntoxicity\tI-Disease\nor\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nAdverse\tO\ngastrointestinal\tO\neffects\tO\nwere\tO\nuncommon\tO\n.\tO\n\nOn\tO\nthe\tO\nbasis\tO\nof\tO\nthe\tO\nfindings\tO\nreported\tO\nherein\tO\n,\tO\na\tO\ndose\tO\nof\tO\n60\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nof\tO\nCCNU\tB-Chemical\ncombined\tO\nwith\tO\n250\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nof\tO\nCTX\tB-Chemical\n(\tO\ndivided\tO\nover\tO\n5\tO\ndays\tO\n)\tO\nq\tO\n4\tO\nwk\tO\nis\tO\ntolerable\tO\nin\tO\ntumor\tB-Disease\n-\tO\nbearing\tO\ndogs\tO\n.\tO\n\nNelarabine\tB-Chemical\nneurotoxicity\tB-Disease\nwith\tO\nconcurrent\tO\nintrathecal\tO\nchemotherapy\tO\n:\tO\nCase\tO\nreport\tO\nand\tO\nreview\tO\nof\tO\nliterature\tO\n.\tO\n\nSevere\tO\nnelarabine\tB-Chemical\nneurotoxicity\tB-Disease\nin\tO\na\tO\npatient\tO\nwho\tO\nreceived\tO\nconcurrent\tO\nintrathecal\tO\n(\tO\nIT\tO\n)\tO\nchemotherapy\tO\nis\tO\nreported\tO\n.\tO\n\nA\tO\n37\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nCaucasian\tO\nwoman\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nT\tB-Disease\n-\tI-Disease\ncell\tI-Disease\nlymphoblastic\tI-Disease\nlymphoma\tI-Disease\nwas\tO\nadmitted\tO\nfor\tO\nrelapsed\tO\ndisease\tO\n.\tO\n\nShe\tO\nwas\tO\noriginally\tO\ntreated\tO\nwith\tO\ninduction\tO\nchemotherapy\tO\nfollowed\tO\nby\tO\nan\tO\nautologous\tO\ntransplant\tO\n.\tO\n\nShe\tO\ndeveloped\tO\nrelapsed\tO\ndisease\tO\n10\tO\nmonths\tO\nlater\tO\nwith\tO\nleukemic\tB-Disease\ninvolvement\tO\n.\tO\n\nShe\tO\nwas\tO\nre\tO\n-\tO\ninduced\tO\nwith\tO\nnelarabine\tB-Chemical\n1500\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\non\tO\ndays\tO\n1\tO\n,\tO\n3\tO\n,\tO\nand\tO\n5\tO\nwith\tO\n1\tO\ndose\tO\nof\tO\nIT\tO\ncytarabine\tB-Chemical\n100\tO\nmg\tO\non\tO\nday\tO\n2\tO\nas\tO\ncentral\tO\nnervous\tO\nsystem\tO\n(\tO\nCNS\tO\n)\tO\nprophylaxis\tO\n.\tO\n\nAt\tO\nthe\tO\ntime\tO\nof\tO\ntreatment\tO\n,\tO\nshe\tO\nwas\tO\non\tO\ncontinuous\tO\nrenal\tO\nreplacement\tO\ntherapy\tO\ndue\tO\nto\tO\nsequelae\tO\nof\tO\ntumor\tB-Disease\nlysis\tI-Disease\nsyndrome\tI-Disease\n(\tO\nTLS\tB-Disease\n)\tO\n.\tO\n\nShe\tO\ntolerated\tO\ntherapy\tO\nwell\tO\n,\tO\nentered\tO\na\tO\ncomplete\tO\nremission\tO\n,\tO\nand\tO\nrecovered\tO\nher\tO\nrenal\tO\nfunction\tO\n.\tO\n\nShe\tO\nreceived\tO\na\tO\nsecond\tO\ncycle\tO\nof\tO\nnelarabine\tB-Chemical\nwithout\tO\nadditional\tO\nIT\tO\nprophylaxis\tO\none\tO\nmonth\tO\nlater\tO\n.\tO\n\nA\tO\nweek\tO\nafter\tO\nthis\tO\nsecond\tO\ncycle\tO\n,\tO\nshe\tO\nnoted\tO\nnumbness\tO\nin\tO\nher\tO\nlower\tO\nextremities\tO\n.\tO\n\nPredominantly\tO\nsensory\tO\n,\tO\nthough\tO\nalso\tO\nmotor\tO\nand\tO\nautonomic\tO\n,\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\nstarted\tO\nin\tO\nher\tO\nfeet\tO\n,\tO\nascended\tO\nproximally\tO\nto\tO\nthe\tO\nmid\tO\n-\tO\nthoracic\tO\nregion\tO\n,\tO\nand\tO\neventually\tO\nincluded\tO\nher\tO\ndistal\tO\nupper\tO\nextremities\tO\n.\tO\n\nA\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n(\tO\nMRI\tO\n)\tO\nof\tO\nher\tO\nspine\tO\ndemonstrated\tO\nchanges\tO\nfrom\tO\nC2\tO\nto\tO\nC6\tO\nconsistent\tO\nwith\tO\nsubacute\tO\ncombined\tO\ndegeneration\tO\n.\tO\n\nNelarabine\tB-Chemical\nwas\tO\nfelt\tO\nto\tO\nbe\tO\nthe\tO\ncause\tO\nof\tO\nher\tO\nsymptoms\tO\n.\tO\n\nHer\tO\nneuropathy\tB-Disease\nstabilized\tO\nand\tO\nshowed\tO\nslight\tO\nimprovement\tO\nand\tO\nultimately\tO\nreceived\tO\nan\tO\nunrelated\tO\n,\tO\nreduced\tO\n-\tO\nintensity\tO\nallogeneic\tO\ntransplant\tO\nwhile\tO\nin\tO\ncomplete\tO\nremission\tO\n,\tO\nbut\tO\nrelapsed\tO\ndisease\tO\n10\tO\nweeks\tO\nlater\tO\n.\tO\n\nShe\tO\nis\tO\ncurrently\tO\nbeing\tO\ntreated\tO\nwith\tO\nbest\tO\nsupportive\tO\ncare\tO\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\npublished\tO\ncase\tO\nreport\tO\nof\tO\nsevere\tO\nneurotoxicity\tB-Disease\ncaused\tO\nby\tO\nnelarabine\tB-Chemical\nin\tO\na\tO\npatient\tO\nwho\tO\nreceived\tO\nconcurrent\tO\nIT\tO\nchemotherapy\tO\n.\tO\n\nValproate\tB-Chemical\n-\tO\ninduced\tO\nhyperammonemic\tB-Disease\nencephalopathy\tB-Disease\nin\tO\na\tO\nrenal\tO\ntransplanted\tO\npatient\tO\n.\tO\n\nNeurological\tB-Disease\ncomplications\tI-Disease\nafter\tO\nrenal\tO\ntransplantation\tO\nconstitute\tO\nan\tO\nimportant\tO\ncause\tO\nof\tO\nmorbidity\tO\nand\tO\nmortality\tO\n.\tO\n\nTheir\tO\ndifferential\tO\ndiagnosis\tO\nis\tO\ndifficult\tO\nand\tO\nessential\tO\nfor\tO\nsubsequent\tO\npatient\tO\n'\tO\ns\tO\nmanagement\tO\n.\tO\n\nValproate\tB-Chemical\n-\tO\ninduced\tO\nhyperammonemic\tB-Disease\nencephalopathy\tB-Disease\nis\tO\nan\tO\nuncommon\tO\nbut\tO\nserious\tO\neffect\tO\nof\tO\nvalproate\tB-Chemical\ntreatment\tO\n.\tO\n\nHere\tO\n,\tO\nwe\tO\ndescribe\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n15\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ngirl\tO\nwho\tO\nwas\tO\non\tO\na\tO\nlong\tO\n-\tO\nterm\tO\ntherapy\tO\nwith\tO\nvalproate\tB-Chemical\ndue\tO\nto\tO\nepilepsy\tB-Disease\nand\tO\nrevealed\tO\nimpaired\tB-Disease\nconsciousness\tI-Disease\nwith\tO\nhyperammonemia\tB-Disease\n12\tO\ndays\tO\nafter\tO\nrenal\tO\ntransplantation\tO\n.\tO\n\nAfter\tO\nwithdraw\tO\nof\tO\nvalproate\tB-Chemical\n,\tO\npatients\tO\n'\tO\nsymptoms\tO\nresolved\tO\nwithin\tO\n24\tO\nh\tO\n.\tO\n\nClinicians\tO\nshould\tO\nincrease\tO\ntheir\tO\nawareness\tO\nfor\tO\npotential\tO\ncomplication\tO\nof\tO\nvalproate\tB-Chemical\n,\tO\nespecially\tO\nin\tO\ntransplanted\tO\npatients\tO\n.\tO\n\nNecrotising\tB-Disease\nfasciitis\tI-Disease\nafter\tO\nbortezomib\tB-Chemical\nand\tO\ndexamethasone\tB-Chemical\n-\tO\ncontaining\tO\nregimen\tO\nin\tO\nan\tO\nelderly\tO\npatient\tO\nof\tO\nWaldenstrom\tB-Disease\nmacroglobulinaemia\tI-Disease\n.\tO\n\nBortezomib\tB-Chemical\nand\tO\nhigh\tO\n-\tO\ndose\tO\ndexamethasone\tB-Chemical\n-\tO\ncontaining\tO\nregimens\tO\nare\tO\nconsidered\tO\nto\tO\nbe\tO\ngenerally\tO\ntolerable\tO\nwith\tO\nfew\tO\nsevere\tO\nbacterial\tB-Disease\ninfections\tI-Disease\nin\tO\npatients\tO\nwith\tO\nB\tO\n-\tO\ncell\tO\nmalignancies\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\ninformation\tO\nis\tO\nlimited\tO\nconcerning\tO\nthe\tO\nsafety\tO\nof\tO\nthe\tO\nregimen\tO\nin\tO\nelderly\tO\npatients\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\n76\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nWaldenstrom\tB-Disease\nmacroglobulinaemia\tI-Disease\nwho\tO\nsuffered\tO\nnecrotising\tB-Disease\nfasciitis\tI-Disease\nwithout\tO\nneutropenia\tB-Disease\nafter\tO\nthe\tO\ncombination\tO\ntreatment\tO\nwith\tO\nbortezomib\tB-Chemical\n,\tO\nhigh\tO\n-\tO\ndose\tO\ndexamethasone\tB-Chemical\nand\tO\nrituximab\tO\n.\tO\n\nDespite\tO\nimmediate\tO\nintravenous\tO\nantimicrobial\tO\ntherapy\tO\n,\tO\nhe\tO\nsuccumbed\tO\n23\tO\nh\tO\nafter\tO\nthe\tO\nonset\tO\n.\tO\n\nPhysicians\tO\nshould\tO\nrecognise\tO\nthe\tO\npossibility\tO\nof\tO\nfatal\tO\nbacterial\tB-Disease\ninfections\tI-Disease\nrelated\tO\nto\tO\nbortezomib\tB-Chemical\nplus\tO\nhigh\tO\n-\tO\ndose\tO\ndexamethasone\tB-Chemical\nin\tO\nelderly\tO\npatients\tO\n,\tO\nand\tO\nwe\tO\nbelieve\tO\nthis\tO\ncase\tO\nwarrants\tO\nfurther\tO\ninvestigation\tO\n.\tO\n\nAn\tO\nintegrated\tO\ncharacterization\tO\nof\tO\nserological\tO\n,\tO\npathological\tO\n,\tO\nand\tO\nfunctional\tO\nevents\tO\nin\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nMany\tO\nefficacious\tO\ncancer\tB-Disease\ntreatments\tO\ncause\tO\nsignificant\tO\ncardiac\tO\nmorbidity\tO\n,\tO\nyet\tO\nbiomarkers\tO\nor\tO\nfunctional\tO\nindices\tO\nof\tO\nearly\tO\ndamage\tO\n,\tO\nwhich\tO\nwould\tO\nallow\tO\nmonitoring\tO\nand\tO\nintervention\tO\n,\tO\nare\tO\nlacking\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\nhave\tO\nutilized\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nprogressive\tO\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\n,\tO\napplying\tO\nmultiple\tO\napproaches\tO\n,\tO\nincluding\tO\ncardiac\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n(\tO\nMRI\tO\n)\tO\n,\tO\nto\tO\nprovide\tO\nthe\tO\nmost\tO\ncomprehensive\tO\ncharacterization\tO\nto\tO\ndate\tO\nof\tO\nthe\tO\ntimecourse\tO\nof\tO\nserological\tO\n,\tO\npathological\tO\n,\tO\nand\tO\nfunctional\tO\nevents\tO\nunderlying\tO\nthis\tO\ntoxicity\tB-Disease\n.\tO\n\nHannover\tO\nWistar\tO\nrats\tO\nwere\tO\ndosed\tO\nwith\tO\n1\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nDOX\tB-Chemical\nweekly\tO\nfor\tO\n8\tO\nweeks\tO\nfollowed\tO\nby\tO\na\tO\n4\tO\nweek\tO\noff\tO\n-\tO\ndosing\tO\n\"\tO\nrecovery\tO\n\"\tO\nperiod\tO\n.\tO\n\nElectron\tO\nmicroscopy\tO\nof\tO\nthe\tO\nmyocardium\tO\nrevealed\tO\nsubcellular\tB-Disease\ndegeneration\tI-Disease\nand\tO\nmarked\tO\nmitochondrial\tO\nchanges\tO\nafter\tO\na\tO\nsingle\tO\ndose\tO\n.\tO\n\nHistopathological\tO\nanalysis\tO\nrevealed\tO\nprogressive\tO\ncardiomyocyte\tB-Disease\ndegeneration\tI-Disease\n,\tO\nhypertrophy\tB-Disease\n/\tO\ncytomegaly\tO\n,\tO\nand\tO\nextensive\tO\nvacuolation\tO\nafter\tO\ntwo\tO\ndoses\tO\n.\tO\n\nExtensive\tO\nreplacement\tO\nfibrosis\tB-Disease\n(\tO\nquantified\tO\nby\tO\nSirius\tO\nred\tO\nstaining\tO\n)\tO\ndeveloped\tO\nduring\tO\nthe\tO\noff\tO\n-\tO\ndosing\tO\nperiod\tO\n.\tO\n\nFunctional\tO\nindices\tO\nassessed\tO\nby\tO\ncardiac\tO\nMRI\tO\n(\tO\nincluding\tO\nleft\tO\nventricular\tO\nejection\tO\nfraction\tO\n(\tO\nLVEF\tO\n)\tO\n,\tO\ncardiac\tO\noutput\tO\n,\tO\nand\tO\nE\tO\n/\tO\nA\tO\nratio\tO\n)\tO\ndeclined\tO\nprogressively\tO\n,\tO\nreaching\tO\nstatistical\tO\nsignificance\tO\nafter\tO\ntwo\tO\ndoses\tO\nand\tO\nculminating\tO\nin\tO\n\"\tO\nclinical\tO\n\"\tO\nLV\tB-Disease\ndysfunction\tI-Disease\nby\tO\n12\tO\nweeks\tO\n.\tO\n\nSignificant\tO\nincreases\tO\nin\tO\npeak\tO\nmyocardial\tO\ncontrast\tO\nenhancement\tO\nand\tO\nserological\tO\ncardiac\tO\ntroponin\tO\nI\tO\n(\tO\ncTnI\tO\n)\tO\nemerged\tO\nafter\tO\neight\tO\ndoses\tO\n,\tO\nimportantly\tO\npreceding\tO\nthe\tO\nLVEF\tO\ndecline\tO\nto\tO\n<\tO\n50\tO\n%\tO\n.\tO\n\nTroponin\tO\nI\tO\nlevels\tO\npositively\tO\ncorrelated\tO\nwith\tO\ndelayed\tO\nand\tO\npeak\tO\ngadolinium\tB-Chemical\ncontrast\tO\nenhancement\tO\n,\tO\nhistopathological\tO\ngrading\tO\n,\tO\nand\tO\ndiastolic\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nIn\tO\nsummary\tO\n,\tO\nsubcellular\tO\ncardiomyocyte\tB-Disease\ndegeneration\tI-Disease\nwas\tO\nthe\tO\nearliest\tO\nmarker\tO\n,\tO\nfollowed\tO\nby\tO\nprogressive\tO\nfunctional\tO\ndecline\tO\nand\tO\nhistopathological\tO\nmanifestations\tO\n.\tO\n\nMyocardial\tO\ncontrast\tO\nenhancement\tO\nand\tO\nelevations\tO\nin\tO\ncTnI\tO\noccurred\tO\nlater\tO\n.\tO\n\nHowever\tO\n,\tO\nall\tO\nindices\tO\npredated\tO\n\"\tO\nclinical\tO\n\"\tO\nLV\tB-Disease\ndysfunction\tI-Disease\nand\tO\nthus\tO\nwarrant\tO\nfurther\tO\nevaluation\tO\nas\tO\npredictive\tO\nbiomarkers\tO\n.\tO\n\nIntradermal\tO\nglutamate\tB-Chemical\nand\tO\ncapsaicin\tB-Chemical\ninjections\tO\n:\tO\nintra\tO\n-\tO\nand\tO\ninterindividual\tO\nvariability\tO\nof\tO\nprovoked\tO\nhyperalgesia\tB-Disease\nand\tO\nallodynia\tB-Disease\n.\tO\n\nIntradermal\tO\ninjections\tO\nof\tO\nglutamate\tB-Chemical\nand\tO\ncapsaicin\tB-Chemical\nare\tO\nattractive\tO\nto\tO\nuse\tO\nin\tO\nhuman\tO\nexperimental\tO\npain\tB-Disease\nmodels\tO\nbecause\tO\nhyperalgesia\tB-Disease\nand\tO\nallodynia\tB-Disease\nmimic\tO\nisolated\tO\naspects\tO\nof\tO\nclinical\tO\npain\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthe\tO\nreproducibility\tO\nof\tO\nthese\tO\nmodels\tO\n.\tO\n\nTwenty\tO\nhealthy\tO\nmale\tO\nvolunteers\tO\n(\tO\nmean\tO\nage\tO\n24\tO\nyears\tO\n;\tO\nrange\tO\n18\tO\n-\tO\n38\tO\nyears\tO\n)\tO\nreceived\tO\nintradermal\tO\ninjections\tO\nof\tO\nglutamate\tB-Chemical\nand\tO\ncapsaicin\tB-Chemical\nin\tO\nthe\tO\nvolar\tO\nforearm\tO\n.\tO\n\nMagnitudes\tO\nof\tO\nsecondary\tO\npinprick\tO\nhyperalgesia\tB-Disease\nand\tO\nbrush\tO\n-\tO\nevoked\tO\nallodynia\tB-Disease\nwere\tO\ninvestigated\tO\nusing\tO\nvon\tO\nFrey\tO\nfilaments\tO\n(\tO\ngauges\tO\n10\tO\n,\tO\n15\tO\n,\tO\n60\tO\nand\tO\n100\tO\ng\tO\n)\tO\nand\tO\nbrush\tO\nstrokes\tO\n.\tO\n\nAreas\tO\nof\tO\nsecondary\tB-Disease\nhyperalgesia\tI-Disease\nand\tO\nallodynia\tB-Disease\nwere\tO\nquantified\tO\nimmediately\tO\nafter\tO\ninjection\tO\nand\tO\nafter\tO\n15\tO\n,\tO\n30\tO\nand\tO\n60\tO\nmin\tO\n.\tO\n\nTwo\tO\nidentical\tO\nexperiments\tO\nseparated\tO\nby\tO\nat\tO\nleast\tO\n7\tO\ndays\tO\nwere\tO\nperformed\tO\n.\tO\n\nReproducibility\tO\nacross\tO\nand\tO\nwithin\tO\nvolunteers\tO\n(\tO\ninter\tO\n-\tO\nand\tO\nintra\tO\n-\tO\nindividual\tO\nvariation\tO\n,\tO\nrespectively\tO\n)\tO\nwas\tO\nassessed\tO\nusing\tO\nintraclass\tO\ncorrelation\tO\ncoefficient\tO\n(\tO\nICC\tO\n)\tO\nand\tO\ncoefficient\tO\nof\tO\nvariation\tO\n(\tO\nCV\tO\n)\tO\n.\tO\n\nSecondary\tO\npinprick\tO\nhyperalgesia\tB-Disease\nwas\tO\nobserved\tO\nas\tO\na\tO\nmarked\tO\nincrease\tO\nin\tO\nthe\tO\nvisual\tO\nanalogue\tO\nscale\tO\n(\tO\nVAS\tO\n)\tO\nresponse\tO\nto\tO\nvon\tO\nFrey\tO\ngauges\tO\n60\tO\nand\tO\n100\tO\ng\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nafter\tO\nglutamate\tB-Chemical\ninjection\tO\n.\tO\n\nFor\tO\ncapsaicin\tB-Chemical\n,\tO\nsecondary\tO\npinprick\tO\nhyperalgesia\tB-Disease\nwas\tO\ndetected\tO\nwith\tO\nall\tO\nvon\tO\nFrey\tO\ngauges\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nGlutamate\tB-Chemical\nevoked\tO\nreproducible\tO\nVAS\tO\nresponse\tO\nto\tO\nall\tO\nvon\tO\nFrey\tO\ngauges\tO\n(\tO\nICC\tO\n>\tO\n0\tO\n.\tO\n60\tO\n)\tO\nand\tO\nbrush\tO\nstrokes\tO\n(\tO\nICC\tO\n>\tO\n0\tO\n.\tO\n83\tO\n)\tO\n.\tO\n\nCapsaicin\tB-Chemical\ninjection\tO\nwas\tO\nreproducible\tO\nfor\tO\nsecondary\tB-Disease\nhyperalgesia\tI-Disease\n(\tO\nICC\tO\n>\tO\n0\tO\n.\tO\n70\tO\n)\tO\nand\tO\nallodynia\tB-Disease\n(\tO\nICC\tO\n>\tO\n0\tO\n.\tO\n71\tO\n)\tO\n.\tO\n\nIntra\tO\n-\tO\nindividual\tO\nvariability\tO\nwas\tO\ngenerally\tO\nlower\tO\nfor\tO\nthe\tO\nVAS\tO\nresponse\tO\nto\tO\nvon\tO\nFrey\tO\nand\tO\nbrush\tO\ncompared\tO\nwith\tO\nareas\tO\nof\tO\nsecondary\tB-Disease\nhyperalgesia\tI-Disease\nand\tO\nallodynia\tB-Disease\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nglutamate\tB-Chemical\nand\tO\ncapsaicin\tB-Chemical\nyield\tO\nreproducible\tO\nhyperalgesic\tB-Disease\nand\tO\nallodynic\tB-Disease\nresponses\tO\n,\tO\nand\tO\nthe\tO\npresent\tO\nmodel\tO\nis\tO\nwell\tO\nsuited\tO\nfor\tO\nbasic\tO\nresearch\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nfor\tO\nassessing\tO\nthe\tO\nmodulation\tO\nof\tO\ncentral\tO\nphenomena\tO\n.\tO\n\nOcular\tO\n-\tO\nspecific\tO\nER\tO\nstress\tO\nreduction\tO\nrescues\tO\nglaucoma\tB-Disease\nin\tO\nmurine\tO\nglucocorticoid\tO\n-\tO\ninduced\tO\nglaucoma\tB-Disease\n.\tO\n\nAdministration\tO\nof\tO\nglucocorticoids\tO\ninduces\tO\nocular\tB-Disease\nhypertension\tI-Disease\nin\tO\nsome\tO\npatients\tO\n.\tO\n\nIf\tO\nuntreated\tO\n,\tO\nthese\tO\npatients\tO\ncan\tO\ndevelop\tO\na\tO\nsecondary\tO\nglaucoma\tB-Disease\nthat\tO\nresembles\tO\nprimary\tB-Disease\nopen\tI-Disease\n-\tI-Disease\nangle\tI-Disease\nglaucoma\tI-Disease\n(\tO\nPOAG\tB-Disease\n)\tO\n.\tO\n\nThe\tO\nunderlying\tO\npathology\tO\nof\tO\nglucocorticoid\tO\n-\tO\ninduced\tO\nglaucoma\tB-Disease\nis\tO\nnot\tO\nfully\tO\nunderstood\tO\n,\tO\ndue\tO\nin\tO\npart\tO\nto\tO\nlack\tO\nof\tO\nan\tO\nappropriate\tO\nanimal\tO\nmodel\tO\n.\tO\n\nHere\tO\n,\tO\nwe\tO\ndeveloped\tO\na\tO\nmurine\tO\nmodel\tO\nof\tO\nglucocorticoid\tO\n-\tO\ninduced\tO\nglaucoma\tB-Disease\nthat\tO\nexhibits\tO\nglaucoma\tB-Disease\nfeatures\tO\nthat\tO\nare\tO\nobserved\tO\nin\tO\npatients\tO\n.\tO\n\nTreatment\tO\nof\tO\nWT\tO\nmice\tO\nwith\tO\ntopical\tO\nocular\tO\n0\tO\n.\tO\n1\tO\n%\tO\ndexamethasone\tB-Chemical\nled\tO\nto\tO\nelevation\tO\nof\tO\nintraocular\tO\npressure\tO\n(\tO\nIOP\tO\n)\tO\n,\tO\nfunctional\tO\nand\tO\nstructural\tO\nloss\tO\nof\tO\nretinal\tB-Disease\nganglion\tI-Disease\ncells\tO\n,\tO\nand\tO\naxonal\tB-Disease\ndegeneration\tI-Disease\n,\tO\nresembling\tO\nglucocorticoid\tO\n-\tO\ninduced\tO\nglaucoma\tB-Disease\nin\tO\nhuman\tO\npatients\tO\n.\tO\n\nFurthermore\tO\n,\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nocular\tB-Disease\nhypertension\tI-Disease\nwas\tO\nassociated\tO\nwith\tO\nchronic\tO\nER\tO\nstress\tO\nof\tO\nthe\tO\ntrabecular\tO\nmeshwork\tO\n(\tO\nTM\tO\n)\tO\n.\tO\n\nSimilar\tO\nto\tO\npatients\tO\n,\tO\nwithdrawal\tO\nof\tO\ndexamethasone\tB-Chemical\ntreatment\tO\nreduced\tO\nelevated\tO\nIOP\tO\nand\tO\nER\tO\nstress\tO\nin\tO\nthis\tO\nanimal\tO\nmodel\tO\n.\tO\n\nDexamethasone\tB-Chemical\ninduced\tO\nthe\tO\ntranscriptional\tO\nfactor\tO\nCHOP\tO\n,\tO\na\tO\nmarker\tO\nfor\tO\nchronic\tO\nER\tO\nstress\tO\n,\tO\nin\tO\nthe\tO\nanterior\tO\nsegment\tO\ntissues\tO\n,\tO\nand\tO\nChop\tO\ndeletion\tO\nreduced\tO\nER\tO\nstress\tO\nin\tO\nthese\tO\ntissues\tO\nand\tO\nprevented\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nocular\tB-Disease\nhypertension\tI-Disease\n.\tO\n\nFurthermore\tO\n,\tO\nreduction\tO\nof\tO\nER\tO\nstress\tO\nin\tO\nthe\tO\nTM\tO\nwith\tO\nsodium\tB-Chemical\n4\tI-Chemical\n-\tI-Chemical\nphenylbutyrate\tI-Chemical\nprevented\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nocular\tB-Disease\nhypertension\tI-Disease\nin\tO\nWT\tO\nmice\tO\n.\tO\n\nOur\tO\ndata\tO\nindicate\tO\nthat\tO\nER\tO\nstress\tO\ncontributes\tO\nto\tO\nglucocorticoid\tO\n-\tO\ninduced\tO\nocular\tB-Disease\nhypertension\tI-Disease\nand\tO\nsuggest\tO\nthat\tO\nreducing\tO\nER\tO\nstress\tO\nhas\tO\npotential\tO\nas\tO\na\tO\ntherapeutic\tO\nstrategy\tO\nfor\tO\ntreating\tO\nglucocorticoid\tO\n-\tO\ninduced\tO\nglaucoma\tB-Disease\n.\tO\n\nEffects\tO\nof\tO\nginsenosides\tB-Chemical\non\tO\nopioid\tO\n-\tO\ninduced\tO\nhyperalgesia\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nOpioid\tO\n-\tO\ninduced\tO\nhyperalgesia\tB-Disease\n(\tO\nOIH\tB-Disease\n)\tO\nis\tO\ncharacterized\tO\nby\tO\nnociceptive\tO\nsensitization\tO\ncaused\tO\nby\tO\nthe\tO\ncessation\tO\nof\tO\nchronic\tO\nopioid\tO\nuse\tO\n.\tO\n\nOIH\tB-Disease\ncan\tO\nlimit\tO\nthe\tO\nclinical\tO\nuse\tO\nof\tO\nopioid\tO\nanalgesics\tO\nand\tO\ncomplicate\tO\nwithdrawal\tO\nfrom\tO\nopioid\tB-Disease\naddiction\tI-Disease\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\neffects\tO\nof\tO\nRe\tB-Chemical\n,\tI-Chemical\nRg1\tI-Chemical\n,\tI-Chemical\nand\tI-Chemical\nRb1\tI-Chemical\nginsenosides\tI-Chemical\n,\tO\nthe\tO\nbioactive\tO\ncomponents\tO\nof\tO\nginseng\tO\n,\tO\non\tO\nOIH\tB-Disease\n.\tO\n\nOIH\tB-Disease\nwas\tO\nachieved\tO\nin\tO\nmice\tO\nafter\tO\nsubcutaneous\tO\nadministration\tO\nof\tO\nmorphine\tB-Chemical\nfor\tO\n7\tO\nconsecutive\tO\ndays\tO\nthree\tO\ntimes\tO\nper\tO\nday\tO\n.\tO\n\nDuring\tO\nwithdrawal\tO\n(\tO\ndays\tO\n8\tO\nand\tO\n9\tO\n)\tO\n,\tO\nthese\tO\nmice\tO\nwere\tO\nadministered\tO\nRe\tB-Chemical\n,\tO\nRg1\tB-Chemical\n,\tO\nor\tO\nRb1\tB-Chemical\nintragastrically\tO\ntwo\tO\ntimes\tO\nper\tO\nday\tO\n.\tO\n\nOn\tO\nthe\tO\ntest\tO\nday\tO\n(\tO\nday\tO\n10\tO\n)\tO\n,\tO\nmice\tO\nwere\tO\nsubjected\tO\nto\tO\nthe\tO\nthermal\tO\nsensitivity\tO\ntest\tO\nand\tO\nthe\tO\nacetic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nwrithing\tO\ntest\tO\n.\tO\n\nRe\tB-Chemical\n(\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ninhibited\tO\nOIH\tB-Disease\nin\tO\nboth\tO\nthe\tO\nthermal\tO\nsensitivity\tO\ntest\tO\nand\tO\nthe\tO\nacetic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nwrithing\tO\ntest\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nRg1\tB-Chemical\nand\tI-Chemical\nRb1\tI-Chemical\nginsenosides\tI-Chemical\nfailed\tO\nto\tO\nprevent\tO\nOIH\tB-Disease\nin\tO\neither\tO\ntest\tO\n.\tO\n\nFurthermore\tO\n,\tO\nRg1\tB-Chemical\nshowed\tO\na\tO\ntendency\tO\nto\tO\naggravate\tO\nOIH\tB-Disease\nin\tO\nthe\tO\nacetic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nwrithing\tO\ntest\tO\n.\tO\n\nOur\tO\ndata\tO\nsuggested\tO\nthat\tO\nthe\tO\nginsenoside\tB-Chemical\nRe\tI-Chemical\n,\tO\nbut\tO\nnot\tO\nRg1\tB-Chemical\nor\tO\nRb1\tB-Chemical\n,\tO\nmay\tO\ncontribute\tO\ntoward\tO\nreversal\tO\nof\tO\nOIH\tB-Disease\n.\tO\n\nA\tO\ncomparison\tO\nof\tO\nsevere\tO\nhemodynamic\tO\ndisturbances\tO\nbetween\tO\ndexmedetomidine\tB-Chemical\nand\tO\npropofol\tB-Chemical\nfor\tO\nsedation\tO\nin\tO\nneurocritical\tO\ncare\tO\npatients\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nDexmedetomidine\tB-Chemical\nand\tO\npropofol\tB-Chemical\nare\tO\ncommonly\tO\nused\tO\nsedatives\tO\nin\tO\nneurocritical\tO\ncare\tO\nas\tO\nthey\tO\nallow\tO\nfor\tO\nfrequent\tO\nneurologic\tO\nexaminations\tO\n.\tO\n\nHowever\tO\n,\tO\nboth\tO\nagents\tO\nare\tO\nassociated\tO\nwith\tO\nsignificant\tO\nhemodynamic\tO\nside\tO\neffects\tO\n.\tO\n\nThe\tO\nprimary\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nis\tO\nto\tO\ncompare\tO\nthe\tO\nprevalence\tO\nof\tO\nsevere\tO\nhemodynamic\tO\neffects\tO\nin\tO\nneurocritical\tO\ncare\tO\npatients\tO\nreceiving\tO\ndexmedetomidine\tB-Chemical\nand\tO\npropofol\tB-Chemical\n.\tO\n\nDESIGN\tO\n:\tO\nMulticenter\tO\n,\tO\nretrospective\tO\n,\tO\npropensity\tO\n-\tO\nmatched\tO\ncohort\tO\nstudy\tO\n.\tO\n\nSETTING\tO\n:\tO\nNeurocritical\tO\ncare\tO\nunits\tO\nat\tO\ntwo\tO\nacademic\tO\nmedical\tO\ncenters\tO\nwith\tO\ndedicated\tO\nneurocritical\tO\ncare\tO\nteams\tO\nand\tO\nboard\tO\n-\tO\ncertified\tO\nneurointensivists\tO\n.\tO\n\nPATIENTS\tO\n:\tO\nNeurocritical\tO\ncare\tO\npatients\tO\nadmitted\tO\nbetween\tO\nJuly\tO\n2009\tO\nand\tO\nSeptember\tO\n2012\tO\nwere\tO\nevaluated\tO\nand\tO\nthen\tO\nmatched\tO\n1\tO\n:\tO\n1\tO\nbased\tO\non\tO\npropensity\tO\nscoring\tO\nof\tO\nbaseline\tO\ncharacteristics\tO\n.\tO\n\nINTERVENTIONS\tO\n:\tO\nContinuous\tO\nsedation\tO\nwith\tO\ndexmedetomidine\tB-Chemical\nor\tO\npropofol\tB-Chemical\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nA\tO\ntotal\tO\nof\tO\n342\tO\npatients\tO\n(\tO\n105\tO\ndexmedetomidine\tB-Chemical\nand\tO\n237\tO\npropofol\tB-Chemical\n)\tO\nwere\tO\nincluded\tO\nin\tO\nthe\tO\nanalysis\tO\n,\tO\nwith\tO\n190\tO\nmatched\tO\n(\tO\n95\tO\nin\tO\neach\tO\ngroup\tO\n)\tO\nby\tO\npropensity\tO\nscore\tO\n.\tO\n\nThe\tO\nprimary\tO\noutcome\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\na\tO\ncomposite\tO\nof\tO\nsevere\tO\nhypotension\tB-Disease\n(\tO\nmean\tO\narterial\tO\npressure\tO\n<\tO\n60\tO\nmm\tO\nHg\tO\n)\tO\nand\tO\nbradycardia\tB-Disease\n(\tO\nheart\tO\nrate\tO\n<\tO\n50\tO\nbeats\tO\n/\tO\nmin\tO\n)\tO\nduring\tO\nsedative\tO\ninfusion\tO\n.\tO\n\nNo\tO\ndifference\tO\nin\tO\nthe\tO\nprimary\tO\ncomposite\tO\noutcome\tO\nin\tO\nboth\tO\nthe\tO\nunmatched\tO\n(\tO\n30\tO\n%\tO\nvs\tO\n30\tO\n%\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n94\tO\n)\tO\nor\tO\nmatched\tO\ncohorts\tO\n(\tO\n28\tO\n%\tO\nvs\tO\n34\tO\n%\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n35\tO\n)\tO\ncould\tO\nbe\tO\nfound\tO\n.\tO\n\nWhen\tO\nanalyzed\tO\nseparately\tO\n,\tO\nno\tO\ndifferences\tO\ncould\tO\nbe\tO\nfound\tO\nin\tO\nthe\tO\nprevalence\tO\nof\tO\nsevere\tO\nhypotension\tB-Disease\nor\tO\nbradycardia\tB-Disease\nin\tO\neither\tO\nthe\tO\nunmatched\tO\nor\tO\nmatched\tO\ncohorts\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSevere\tO\nhypotension\tB-Disease\nand\tO\nbradycardia\tB-Disease\noccur\tO\nat\tO\nsimilar\tO\nprevalence\tO\nin\tO\nneurocritical\tO\ncare\tO\npatients\tO\nwho\tO\nreceive\tO\ndexmedetomidine\tB-Chemical\nor\tO\npropofol\tB-Chemical\n.\tO\n\nProviders\tO\nshould\tO\nsimilarly\tO\nconsider\tO\nthe\tO\nlikelihood\tO\nof\tO\nhypotension\tB-Disease\nor\tO\nbradycardia\tB-Disease\nbefore\tO\nstarting\tO\neither\tO\nsedative\tO\n.\tO\n\nHydroxytyrosol\tB-Chemical\nameliorates\tO\noxidative\tO\nstress\tO\nand\tO\nmitochondrial\tB-Disease\ndysfunction\tI-Disease\nin\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nin\tO\nrats\tO\nwith\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nOxidative\tO\nstress\tO\nis\tO\ninvolved\tO\nin\tO\nseveral\tO\nprocesses\tO\nincluding\tO\ncancer\tB-Disease\n,\tO\naging\tO\nand\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n,\tO\nand\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\npotentiate\tO\nthe\tO\ntherapeutic\tO\neffect\tO\nof\tO\ndrugs\tO\nsuch\tO\nas\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nDoxorubicin\tB-Chemical\ncauses\tO\nsignificant\tO\ncardiotoxicity\tB-Disease\ncharacterized\tO\nby\tO\nmarked\tO\nincreases\tO\nin\tO\noxidative\tO\nstress\tO\nand\tO\nmitochondrial\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nHerein\tO\n,\tO\nwe\tO\ninvestigate\tO\nwhether\tO\ndoxorubicin\tB-Chemical\n-\tO\nassociated\tO\nchronic\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\ncan\tO\nbe\tO\nameliorated\tO\nwith\tO\nthe\tO\nantioxidant\tO\nhydroxytyrosol\tB-Chemical\nin\tO\nrats\tO\nwith\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nThirty\tO\n-\tO\nsix\tO\nrats\tO\nbearing\tO\nbreast\tB-Disease\ntumors\tI-Disease\ninduced\tO\nchemically\tO\nwere\tO\ndivided\tO\ninto\tO\n4\tO\ngroups\tO\n:\tO\ncontrol\tO\n,\tO\nhydroxytyrosol\tB-Chemical\n(\tO\n0\tO\n.\tO\n5mg\tO\n/\tO\nkg\tO\n,\tO\n5days\tO\n/\tO\nweek\tO\n)\tO\n,\tO\ndoxorubicin\tB-Chemical\n(\tO\n1mg\tO\n/\tO\nkg\tO\n/\tO\nweek\tO\n)\tO\n,\tO\nand\tO\ndoxorubicin\tB-Chemical\nplus\tO\nhydroxytyrosol\tB-Chemical\n.\tO\n\nCardiac\tB-Disease\ndisturbances\tI-Disease\nat\tO\nthe\tO\ncellular\tO\nand\tO\nmitochondrial\tO\nlevel\tO\n,\tO\nmitochondrial\tO\nelectron\tO\ntransport\tO\nchain\tO\ncomplexes\tO\nI\tO\n-\tO\nIV\tO\nand\tO\napoptosis\tO\n-\tO\ninducing\tO\nfactor\tO\n,\tO\nand\tO\noxidative\tO\nstress\tO\nmarkers\tO\nhave\tO\nbeen\tO\nanalyzed\tO\n.\tO\n\nHydroxytyrosol\tB-Chemical\nimproved\tO\nthe\tO\ncardiac\tB-Disease\ndisturbances\tI-Disease\nenhanced\tO\nby\tO\ndoxorubicin\tB-Chemical\nby\tO\nsignificantly\tO\nreducing\tO\nthe\tO\npercentage\tO\nof\tO\naltered\tO\nmitochondria\tO\nand\tO\noxidative\tO\ndamage\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nhydroxytyrosol\tB-Chemical\nimprove\tO\nthe\tO\nmitochondrial\tO\nelectron\tO\ntransport\tO\nchain\tO\n.\tO\n\nThis\tO\nstudy\tO\ndemonstrates\tO\nthat\tO\nhydroxytyrosol\tB-Chemical\nprotect\tO\nrat\tO\nheart\tB-Disease\ndamage\tI-Disease\nprovoked\tO\nby\tO\ndoxorubicin\tB-Chemical\ndecreasing\tO\noxidative\tO\ndamage\tO\nand\tO\nmitochondrial\tO\nalterations\tO\n.\tO\n\nAmiodarone\tB-Chemical\n-\tO\ninduced\tO\nmyxoedema\tB-Disease\ncoma\tI-Disease\n.\tO\n\nA\tO\n62\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwas\tO\nfound\tO\nto\tO\nhave\tO\nbradycardia\tB-Disease\n,\tO\nhypothermia\tB-Disease\nand\tO\nrespiratory\tB-Disease\nfailure\tI-Disease\n3\tO\nweeks\tO\nafter\tO\ninitiation\tO\nof\tO\namiodarone\tB-Chemical\ntherapy\tO\nfor\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n.\tO\n\nThyroid\tO\n-\tO\nstimulating\tO\nhormone\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\n168\tO\nuIU\tO\n/\tO\nmL\tO\n(\tO\nnl\tO\n.\tO\n0\tO\n.\tO\n3\tO\n-\tO\n5\tO\nuIU\tO\n/\tO\nmL\tO\n)\tO\nand\tO\nfree\tO\nthyroxine\tB-Chemical\n(\tO\nFT4\tO\n)\tO\nwas\tO\n<\tO\n0\tO\n.\tO\n2\tO\nng\tO\n/\tO\ndL\tO\n(\tO\nnl\tO\n.\tO\n0\tO\n.\tO\n8\tO\n-\tO\n1\tO\n.\tO\n8\tO\nng\tO\n/\tO\ndL\tO\n)\tO\n.\tO\n\nHe\tO\nreceived\tO\nintravenous\tO\nfluids\tO\n,\tO\nvasopressor\tO\ntherapy\tO\nand\tO\nstress\tO\ndose\tO\nsteroids\tB-Chemical\n;\tO\nhe\tO\nwas\tO\nintubated\tO\nand\tO\nadmitted\tO\nto\tO\nthe\tO\nintensive\tO\ncare\tO\nunit\tO\n.\tO\n\nHe\tO\nreceived\tO\n500\tO\nug\tO\nof\tO\nintravenous\tO\nlevothyroxine\tB-Chemical\nin\tO\nthe\tO\nfirst\tO\n18\tO\nh\tO\nof\tO\ntherapy\tO\n,\tO\nand\tO\n150\tO\nug\tO\nintravenous\tO\ndaily\tO\nthereafter\tO\n.\tO\n\nHaemodynamic\tO\nimprovement\tO\n,\tO\nalong\tO\nwith\tO\ncomplete\tO\nrecovery\tO\nof\tO\nmental\tO\nstatus\tO\n,\tO\noccurred\tO\nafter\tO\n48\tO\nh\tO\n.\tO\n\nTwelve\tO\nhours\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\ntherapy\tO\n,\tO\nFT4\tO\nwas\tO\n0\tO\n.\tO\n96\tO\nng\tO\n/\tO\ndL\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nmaintained\tO\non\tO\nlevothyroxine\tB-Chemical\n175\tO\n(\tO\ng\tO\nPOorally\tO\ndaily\tO\n.\tO\n\nA\tO\nthyroid\tO\nultrasound\tO\nshowed\tO\ndiffuse\tO\nheterogeneity\tO\n.\tO\n\nThe\tO\n24\tO\nhour\tO\nexcretion\tO\nof\tO\niodine\tB-Chemical\nwas\tO\n3657\tO\n(\tO\nmcg\tO\n(\tO\n25\tO\n-\tO\n756\tO\n(\tO\nmcg\tO\n)\tO\n.\tO\n\nThe\tO\nonly\tO\ntwo\tO\ncases\tO\nof\tO\namiodarone\tB-Chemical\n-\tO\ninduced\tO\nmyxoedema\tB-Disease\ncoma\tI-Disease\nin\tO\nthe\tO\nliterature\tO\nreport\tO\npatient\tO\ndeath\tO\ndespite\tO\nsupportive\tO\ntherapy\tO\nand\tO\nthyroid\tO\nhormone\tO\nreplacement\tO\n.\tO\n\nThis\tO\ncase\tO\nrepresents\tO\nthe\tO\nmost\tO\nthoroughly\tO\ninvestigated\tO\ncase\tO\nof\tO\namiodarone\tB-Chemical\n-\tO\ninduced\tO\nmyxoedema\tB-Disease\ncoma\tI-Disease\nwith\tO\na\tO\nhistory\tO\nsignificant\tO\nfor\tO\nsubclinical\tO\nthyroid\tB-Disease\ndisease\tI-Disease\n.\tO\n\nUse\tO\nof\tO\nargatroban\tB-Chemical\nand\tO\ncatheter\tO\n-\tO\ndirected\tO\nthrombolysis\tB-Disease\nwith\tO\nalteplase\tO\nin\tO\nan\tO\noncology\tO\npatient\tO\nwith\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nwith\tO\nthrombosis\tB-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nThe\tO\ncase\tO\nof\tO\nan\tO\noncology\tO\npatient\tO\nwho\tO\ndeveloped\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nwith\tO\nthrombosis\tB-Disease\n(\tO\nHITT\tB-Disease\n)\tO\nand\tO\nwas\tO\ntreated\tO\nwith\tO\nargatroban\tB-Chemical\nplus\tO\ncatheter\tO\n-\tO\ndirected\tO\nthrombolysis\tB-Disease\n(\tO\nCDT\tO\n)\tO\nwith\tO\nalteplase\tO\nis\tO\npresented\tO\n.\tO\n\nSUMMARY\tO\n:\tO\nA\tO\n63\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nCaucasian\tO\nman\tO\nwith\tO\nrenal\tO\namyloidosis\tB-Disease\nundergoing\tO\nperipheral\tO\nblood\tO\nstem\tO\ncell\tO\ncollection\tO\nfor\tO\nan\tO\nautologous\tO\nstem\tO\ncell\tO\ntransplant\tO\ndeveloped\tO\nextensive\tO\nbilateral\tO\nupper\tB-Disease\n-\tI-Disease\nextremity\tI-Disease\ndeep\tI-Disease\nvenous\tI-Disease\nthrombosis\tI-Disease\n(\tO\nDVT\tB-Disease\n)\tO\nand\tO\npulmonary\tB-Disease\nembolism\tI-Disease\nsecondary\tO\nto\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n.\tO\n\nA\tO\ncontinuous\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusion\tO\nof\tO\nargatroban\tB-Chemical\nwas\tO\ninitiated\tO\n,\tO\nand\tO\nthe\tO\npatient\tO\nwas\tO\nmanaged\tO\non\tO\nthe\tO\ngeneral\tO\nmedical\tO\nfloor\tO\n.\tO\n\nAfter\tO\none\tO\nweek\tO\nof\tO\ntherapy\tO\n,\tO\nhe\tO\nwas\tO\ntransferred\tO\nto\tO\nthe\tO\nintensive\tO\ncare\tO\nunit\tO\nwith\tO\ncardiopulmonary\tO\ncompromise\tO\nrelated\tO\nto\tO\nsuperior\tB-Disease\nvena\tI-Disease\ncava\tI-Disease\n(\tI-Disease\nSVC\tI-Disease\n)\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nA\tO\npercutaneous\tO\nmechanical\tO\nthrombectomy\tO\nand\tO\nCDT\tO\nwith\tO\nalteplase\tO\nwere\tO\nattempted\tO\n,\tO\nbut\tO\nthe\tO\nprocedure\tO\nwas\tO\naborted\tO\ndue\tO\nto\tO\nepistaxis\tB-Disease\n.\tO\n\nThe\tO\nepistaxis\tB-Disease\nresolved\tO\nthe\tO\nnext\tO\nday\tO\n,\tO\nand\tO\nthe\tO\npatient\tO\nwas\tO\nrestarted\tO\non\tO\nargatroban\tB-Chemical\n.\tO\n\nA\tO\nsecond\tO\npercutaneous\tO\nmechanical\tO\nthrombectomy\tO\nwas\tO\nperformed\tO\nsix\tO\ndays\tO\nlater\tO\nand\tO\nresulted\tO\nin\tO\npartial\tO\nrevascularization\tO\nof\tO\nthe\tO\nSVC\tO\nand\tO\ncentral\tO\nveins\tO\n.\tO\n\nPostthrombectomy\tO\ncontinuous\tO\nCDT\tO\nwith\tO\nalteplase\tO\nwas\tO\ncommenced\tO\nwhile\tO\nargatroban\tB-Chemical\nwas\tO\nwithheld\tO\n,\tO\nand\tO\ncomplete\tO\npatency\tO\nof\tO\nthe\tO\nSVC\tO\nand\tO\ncentral\tO\nveins\tO\nwas\tO\nachieved\tO\nafter\tO\nthree\tO\ndays\tO\nof\tO\ntherapy\tO\n.\tO\n\nAlteplase\tO\nwas\tO\ndiscontinued\tO\n,\tO\nand\tO\nthe\tO\npatient\tO\nwas\tO\nreinitiated\tO\non\tO\nargatroban\tB-Chemical\n;\tO\nultimately\tO\n,\tO\nhe\tO\nwas\tO\ntransitioned\tO\nto\tO\nwarfarin\tB-Chemical\nfor\tO\nlong\tO\n-\tO\nterm\tO\nanticoagulation\tO\n.\tO\n\nAlthough\tO\nthe\tO\npatient\tO\nrecovered\tO\n,\tO\nhe\tO\nexperienced\tO\npermanent\tO\nvision\tB-Disease\nand\tI-Disease\nhearing\tI-Disease\nloss\tI-Disease\n,\tO\nas\tO\nwell\tO\nas\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nA\tO\n63\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nrenal\tO\namyloidosis\tB-Disease\nand\tO\nSVC\tB-Disease\nsyndrome\tI-Disease\nsecondary\tO\nto\tO\nHITT\tB-Disease\nwas\tO\nsuccessfully\tO\ntreated\tO\nwith\tO\nargatroban\tB-Chemical\nand\tO\nCDT\tO\nwith\tO\nalteplase\tO\n.\tO\n\nEffects\tO\nof\tO\ndehydroepiandrosterone\tB-Chemical\nin\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nschizophrenia\tB-Disease\nmodels\tO\nin\tO\nmice\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nexamine\tO\nthe\tO\neffects\tO\nof\tO\ndehydroepiandrosterone\tB-Chemical\n(\tO\nDHEA\tB-Chemical\n)\tO\non\tO\nanimal\tO\nmodels\tO\nof\tO\nschizophrenia\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nSeventy\tO\nSwiss\tO\nalbino\tO\nfemale\tO\nmice\tO\n(\tO\n25\tO\n-\tO\n35\tO\ng\tO\n)\tO\nwere\tO\ndivided\tO\ninto\tO\n4\tO\ngroups\tO\n:\tO\namphetamine\tB-Chemical\n-\tO\nfree\tO\n(\tO\ncontrol\tO\n)\tO\n,\tO\namphetamine\tB-Chemical\n,\tO\n50\tO\n,\tO\nand\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\nDHEA\tB-Chemical\n.\tO\n\nThe\tO\nDHEA\tB-Chemical\nwas\tO\nadministered\tO\nintraperitoneally\tO\n(\tO\nip\tO\n)\tO\nfor\tO\n5\tO\ndays\tO\n.\tO\n\nAmphetamine\tB-Chemical\n(\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\ninduced\tO\nhyper\tB-Disease\nlocomotion\tO\n,\tO\napomorphine\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nsubcutaneously\tO\n[\tO\nsc\tO\n]\tO\n)\tO\ninduced\tO\nclimbing\tO\n,\tO\nand\tO\nhaloperidol\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\ninduced\tO\ncatalepsy\tB-Disease\ntests\tO\nwere\tO\nused\tO\nas\tO\nanimal\tO\nmodels\tO\nof\tO\nschizophrenia\tB-Disease\n.\tO\n\nThe\tO\nstudy\tO\nwas\tO\nconducted\tO\nat\tO\nthe\tO\nAnimal\tO\nExperiment\tO\nLaboratories\tO\n,\tO\nDepartment\tO\nof\tO\nPharmacology\tO\n,\tO\nMedical\tO\nSchool\tO\n,\tO\nEskisehir\tO\nOsmangazi\tO\nUniversity\tO\n,\tO\nEskisehir\tO\n,\tO\nTurkey\tO\nbetween\tO\nMarch\tO\nand\tO\nMay\tO\n2012\tO\n.\tO\n\nStatistical\tO\nanalysis\tO\nwas\tO\ncarried\tO\nout\tO\nusing\tO\nKruskal\tO\n-\tO\nWallis\tO\ntest\tO\nfor\tO\nhyper\tB-Disease\nlocomotion\tO\n,\tO\nand\tO\none\tO\n-\tO\nway\tO\nANOVA\tO\nfor\tO\nclimbing\tO\nand\tO\ncatalepsy\tB-Disease\ntests\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIn\tO\nthe\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nlocomotion\tO\ntest\tO\n,\tO\nthere\tO\nwere\tO\nsignificant\tO\nincreases\tO\nin\tO\nall\tO\nmovements\tO\ncompared\tO\nwith\tO\nthe\tO\namphetamine\tB-Chemical\n-\tO\nfree\tO\ngroup\tO\n.\tO\n\nBoth\tO\nDHEA\tB-Chemical\n50\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nand\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nsignificantly\tO\ndecreased\tO\nall\tO\nmovements\tO\ncompared\tO\nwith\tO\nthe\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nlocomotion\tO\ngroup\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\ndifference\tO\nbetween\tO\ngroups\tO\nin\tO\nthe\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\ntest\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nsignificant\tO\ndifference\tO\nbetween\tO\ngroups\tO\nin\tO\nterms\tO\nof\tO\ntotal\tO\nclimbing\tO\ntime\tO\nin\tO\nthe\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nclimbing\tO\ntest\tO\n(\tO\np\tO\n>\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nWe\tO\nobserved\tO\nthat\tO\nDHEA\tB-Chemical\nreduced\tO\nlocomotor\tO\nactivity\tO\nand\tO\nincreased\tO\ncatalepsy\tB-Disease\nat\tO\nboth\tO\ndoses\tO\n,\tO\nwhile\tO\nit\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nclimbing\tO\nbehavior\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\nDHEA\tB-Chemical\ndisplays\tO\ntypical\tO\nneuroleptic\tO\n-\tO\nlike\tO\neffects\tO\n,\tO\nand\tO\nmay\tO\nbe\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nschizophrenia\tB-Disease\n.\tO\n\nAvailability\tO\nof\tO\nhuman\tO\ninduced\tO\npluripotent\tO\nstem\tO\ncell\tO\n-\tO\nderived\tO\ncardiomyocytes\tO\nin\tO\nassessment\tO\nof\tO\ndrug\tO\npotential\tO\nfor\tO\nQT\tB-Disease\nprolongation\tI-Disease\n.\tO\n\nField\tO\npotential\tO\nduration\tO\n(\tO\nFPD\tO\n)\tO\nin\tO\nhuman\tO\n-\tO\ninduced\tO\npluripotent\tO\nstem\tO\ncell\tO\n-\tO\nderived\tO\ncardiomyocytes\tO\n(\tO\nhiPS\tO\n-\tO\nCMs\tO\n)\tO\n,\tO\nwhich\tO\ncan\tO\nexpress\tO\nQT\tO\ninterval\tO\nin\tO\nan\tO\nelectrocardiogram\tO\n,\tO\nis\tO\nreported\tO\nto\tO\nbe\tO\na\tO\nuseful\tO\ntool\tO\nto\tO\npredict\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\nchannel\tO\nand\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nchannel\tO\nblocker\tO\neffects\tO\non\tO\nQT\tO\ninterval\tO\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nis\tO\nno\tO\nreport\tO\nshowing\tO\nthat\tO\nthis\tO\ntechnique\tO\ncan\tO\nbe\tO\nused\tO\nto\tO\npredict\tO\nmultichannel\tO\nblocker\tO\npotential\tO\nfor\tO\nQT\tB-Disease\nprolongation\tI-Disease\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nis\tO\nto\tO\nshow\tO\nthat\tO\nFPD\tO\nfrom\tO\nMEA\tO\n(\tO\nMultielectrode\tO\narray\tO\n)\tO\nof\tO\nhiPS\tO\n-\tO\nCMs\tO\ncan\tO\ndetect\tO\nQT\tB-Disease\nprolongation\tI-Disease\ninduced\tO\nby\tO\nmultichannel\tO\nblockers\tO\n.\tO\n\nhiPS\tO\n-\tO\nCMs\tO\nwere\tO\nseeded\tO\nonto\tO\nMEA\tO\nand\tO\nFPD\tO\nwas\tO\nmeasured\tO\nfor\tO\n2min\tO\nevery\tO\n10min\tO\nfor\tO\n30min\tO\nafter\tO\ndrug\tO\nexposure\tO\nfor\tO\nthe\tO\nvehicle\tO\nand\tO\neach\tO\ndrug\tO\nconcentration\tO\n.\tO\n\nIKr\tO\nand\tO\nIKs\tO\nblockers\tO\nconcentration\tO\n-\tO\ndependently\tO\nprolonged\tO\ncorrected\tO\nFPD\tO\n(\tO\nFPDc\tO\n)\tO\n,\tO\nwhereas\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nchannel\tO\nblockers\tO\nconcentration\tO\n-\tO\ndependently\tO\nshortened\tO\nFPDc\tO\n.\tO\n\nAlso\tO\n,\tO\nthe\tO\nmultichannel\tO\nblockers\tO\nAmiodarone\tB-Chemical\n,\tO\nParoxetine\tB-Chemical\n,\tO\nTerfenadine\tB-Chemical\nand\tO\nCitalopram\tB-Chemical\nprolonged\tO\nFPDc\tO\nin\tO\na\tO\nconcentration\tO\ndependent\tO\nmanner\tO\n.\tO\n\nFinally\tO\n,\tO\nthe\tO\nIKr\tO\nblockers\tO\n,\tO\nTerfenadine\tB-Chemical\nand\tO\nCitalopram\tB-Chemical\n,\tO\nwhich\tO\nare\tO\nreported\tO\nto\tO\ncause\tO\nTorsade\tB-Disease\nde\tI-Disease\nPointes\tI-Disease\n(\tO\nTdP\tB-Disease\n)\tO\nin\tO\nclinical\tO\npractice\tO\n,\tO\nproduced\tO\nearly\tO\nafterdepolarization\tO\n(\tO\nEAD\tO\n)\tO\n.\tO\n\nhiPS\tO\n-\tO\nCMs\tO\nusing\tO\nMEA\tO\nsystem\tO\nand\tO\nFPDc\tO\ncan\tO\npredict\tO\nthe\tO\neffects\tO\nof\tO\ndrug\tO\ncandidates\tO\non\tO\nQT\tO\ninterval\tO\n.\tO\n\nThis\tO\nstudy\tO\nalso\tO\nshows\tO\nthat\tO\nthis\tO\nassay\tO\ncan\tO\nhelp\tO\ndetect\tO\nEAD\tO\nfor\tO\ndrugs\tO\nwith\tO\nTdP\tB-Disease\npotential\tO\n.\tO\n\nDermal\tO\ndevelopmental\tO\ntoxicity\tB-Disease\nof\tO\nN\tO\n-\tO\nphenylimide\tO\nherbicides\tO\nin\tO\nrats\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nS\tB-Chemical\n-\tI-Chemical\n53482\tI-Chemical\nand\tO\nS\tB-Chemical\n-\tI-Chemical\n23121\tI-Chemical\nare\tO\nN\tO\n-\tO\nphenylimide\tO\nherbicides\tO\nand\tO\nproduced\tO\nembryolethality\tB-Disease\n,\tO\nteratogenicity\tB-Disease\n(\tO\nmainly\tO\nventricular\tB-Disease\nseptal\tI-Disease\ndefects\tI-Disease\nand\tO\nwavy\tO\nribs\tO\n)\tO\n,\tO\nand\tO\ngrowth\tB-Disease\nretardation\tI-Disease\nin\tO\nrats\tO\nin\tO\nconventional\tO\noral\tO\ndevelopmental\tO\ntoxicity\tB-Disease\nstudies\tO\n.\tO\n\nOur\tO\nobjective\tO\nin\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nwhether\tO\nthe\tO\ncompounds\tO\ninduce\tO\ndevelopmental\tO\ntoxicity\tB-Disease\nvia\tO\nthe\tO\ndermal\tO\nroute\tO\n,\tO\nwhich\tO\nis\tO\nmore\tO\nrelevant\tO\nto\tO\noccupational\tO\nexposure\tO\n,\tO\nhence\tO\nbetter\tO\naddressing\tO\nhuman\tO\nhealth\tO\nrisks\tO\n.\tO\n\nMETHODS\tO\n:\tO\nS\tB-Chemical\n-\tI-Chemical\n53482\tI-Chemical\nwas\tO\nadministered\tO\ndermally\tO\nto\tO\nrats\tO\nat\tO\n30\tO\n,\tO\n100\tO\n,\tO\nand\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\nduring\tO\norganogenesis\tO\n,\tO\nand\tO\nS\tB-Chemical\n-\tI-Chemical\n23121\tI-Chemical\nwas\tO\nadministered\tO\nat\tO\n200\tO\n,\tO\n400\tO\n,\tO\nand\tO\n800\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\nthe\tO\nmaximum\tO\napplicable\tO\ndose\tO\nlevel\tO\n)\tO\n.\tO\n\nFetuses\tO\nwere\tO\nobtained\tO\nby\tO\na\tO\nCesarean\tO\nsection\tO\nand\tO\nexamined\tO\nfor\tO\nexternal\tO\n,\tO\nvisceral\tO\n,\tO\nand\tO\nskeletal\tO\nalterations\tO\n.\tO\n\nRESULTS\tO\n:\tO\nDermal\tO\nexposure\tO\nof\tO\nrats\tO\nto\tO\nS\tB-Chemical\n-\tI-Chemical\n53482\tI-Chemical\nat\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\nproduced\tO\npatterns\tO\nof\tO\ndevelopmental\tO\ntoxicity\tB-Disease\nsimilar\tO\nto\tO\nthose\tO\nresulting\tO\nfrom\tO\noral\tO\nexposure\tO\n.\tO\n\nToxicity\tB-Disease\nincluded\tO\nembryolethality\tB-Disease\n,\tO\nteratogenicity\tB-Disease\n,\tO\nand\tO\ngrowth\tB-Disease\nretardation\tI-Disease\n.\tO\n\nDermal\tO\nadministration\tO\nof\tO\nS\tB-Chemical\n-\tI-Chemical\n23121\tI-Chemical\nat\tO\n800\tO\nmg\tO\n/\tO\nkg\tO\nresulted\tO\nin\tO\nan\tO\nincreased\tO\nincidence\tO\nof\tO\nembryonic\tB-Disease\ndeath\tI-Disease\nand\tO\nventricular\tB-Disease\nseptal\tI-Disease\ndefect\tI-Disease\n,\tO\nbut\tO\nretarded\tO\nfetal\tO\ngrowth\tO\nwas\tO\nnot\tO\nobserved\tO\nas\tO\nit\tO\nwas\tO\nfollowing\tO\noral\tO\nexposure\tO\nto\tO\nS\tB-Chemical\n-\tI-Chemical\n23121\tI-Chemical\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nBased\tO\non\tO\nthe\tO\nresults\tO\n,\tO\nS\tB-Chemical\n-\tI-Chemical\n53482\tI-Chemical\nand\tO\nS\tB-Chemical\n-\tI-Chemical\n23121\tI-Chemical\nwere\tO\nteratogenic\tB-Disease\nwhen\tO\nadministered\tO\ndermally\tO\nto\tO\npregnant\tO\nrats\tO\nas\tO\nwere\tO\nthe\tO\ncompounds\tO\nadministered\tO\norally\tO\n.\tO\n\nThus\tO\n,\tO\ninvestigation\tO\nof\tO\nthe\tO\nmechanism\tO\nand\tO\nits\tO\nhuman\tO\nrelevancy\tO\nbecome\tO\nmore\tO\nimportant\tO\n.\tO\n\nRates\tO\nof\tO\nRenal\tB-Disease\nToxicity\tI-Disease\nin\tO\nCancer\tB-Disease\nPatients\tO\nReceiving\tO\nCisplatin\tB-Chemical\nWith\tO\nand\tO\nWithout\tO\nMannitol\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nCisplatin\tB-Chemical\nis\tO\na\tO\nwidely\tO\nused\tO\nantineoplastic\tO\n.\tO\n\nOne\tO\nof\tO\nthe\tO\nmajor\tO\ncomplications\tO\nof\tO\ncisplatin\tB-Chemical\nuse\tO\nis\tO\ndose\tO\n-\tO\nlimiting\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nThere\tO\nare\tO\nmany\tO\nstrategies\tO\nto\tO\nprevent\tO\nthis\tO\ntoxicity\tB-Disease\n,\tO\nincluding\tO\nthe\tO\nuse\tO\nof\tO\nmannitol\tB-Chemical\nas\tO\na\tO\nnephroprotectant\tO\nin\tO\ncombination\tO\nwith\tO\nhydration\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nWe\tO\naimed\tO\nto\tO\nevaluate\tO\nthe\tO\nrates\tO\nof\tO\ncisplatin\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\nin\tO\ncancer\tB-Disease\npatients\tO\nreceiving\tO\nsingle\tO\n-\tO\nagent\tO\ncisplatin\tB-Chemical\nwith\tO\nand\tO\nwithout\tO\nmannitol\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nsingle\tO\n-\tO\ncenter\tO\nretrospective\tO\nanalysis\tO\nwas\tO\na\tO\nquasi\tO\nexperiment\tO\ncreated\tO\nby\tO\nthe\tO\nnational\tO\nmannitol\tB-Chemical\nshortage\tO\n.\tO\n\nData\tO\nwere\tO\ncollected\tO\non\tO\nadult\tO\ncancer\tB-Disease\npatients\tO\nreceiving\tO\nsingle\tO\n-\tO\nagent\tO\ncisplatin\tB-Chemical\nas\tO\nan\tO\noutpatient\tO\nfrom\tO\nJanuary\tO\n2011\tO\nto\tO\nSeptember\tO\n2012\tO\n.\tO\n\nThe\tO\nprimary\tO\noutcome\tO\nwas\tO\nacute\tB-Disease\nkidney\tI-Disease\ninjury\tI-Disease\n(\tO\nAKI\tB-Disease\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nevaluated\tO\n143\tO\npatients\tO\nwho\tO\nreceived\tO\nsingle\tO\n-\tO\nagent\tO\ncisplatin\tB-Chemical\n;\tO\n97\tO\n.\tO\n2\tO\n%\tO\nof\tO\npatients\tO\nhad\tO\nhead\tB-Disease\nand\tI-Disease\nneck\tI-Disease\ncancer\tI-Disease\nas\tO\ntheir\tO\nprimary\tO\nmalignancy\tB-Disease\n.\tO\n\nPatients\tO\nwho\tO\ndid\tO\nnot\tO\nreceive\tO\nmannitol\tB-Chemical\nwere\tO\nmore\tO\nlikely\tO\nto\tO\ndevelop\tO\nnephrotoxicity\tB-Disease\n:\tO\nodds\tO\nratio\tO\n[\tO\nOR\tO\n]\tO\n=\tO\n2\tO\n.\tO\n646\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n1\tO\n.\tO\n008\tO\n,\tO\n6\tO\n.\tO\n944\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n048\tO\n)\tO\n.\tO\n\nPatients\tO\nwho\tO\nreceived\tO\nthe\tO\n100\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ndosing\tO\nand\tO\npatients\tO\nwho\tO\nhad\tO\na\tO\nhistory\tO\nof\tO\nhypertension\tB-Disease\nalso\tO\nhad\tO\na\tO\nhigher\tO\nlikelihood\tO\nof\tO\ndeveloping\tO\nnephrotoxicity\tB-Disease\n:\tO\nOR\tO\n=\tO\n11\tO\n.\tO\n494\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n4\tO\n.\tO\n149\tO\n,\tO\n32\tO\n.\tO\n258\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\nand\tO\nOR\tO\n=\tO\n3\tO\n.\tO\n219\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n=\tO\n1\tO\n.\tO\n228\tO\n,\tO\n8\tO\n.\tO\n439\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n017\tO\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWhen\tO\nlimited\tO\nquantities\tO\nof\tO\nmannitol\tB-Chemical\nare\tO\navailable\tO\n,\tO\nit\tO\nshould\tO\npreferentially\tO\nbe\tO\ngiven\tO\nto\tO\npatients\tO\nat\tO\nparticularly\tO\nhigh\tO\nrisk\tO\nof\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nOur\tO\nanalysis\tO\nsuggests\tO\nthat\tO\nthose\tO\npatients\tO\nreceiving\tO\nthe\tO\ndosing\tO\nschedule\tO\nof\tO\n100\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ncisplatin\tB-Chemical\nevery\tO\n3\tO\nweeks\tO\nand\tO\nthose\tO\nwith\tO\nhypertension\tB-Disease\nare\tO\nat\tO\nthe\tO\ngreatest\tO\nrisk\tO\nof\tO\nnephrotoxicity\tB-Disease\nand\tO\nwould\tO\nbenefit\tO\nfrom\tO\nthe\tO\naddition\tO\nof\tO\nmannitol\tB-Chemical\n.\tO\n\nMetformin\tB-Chemical\nprotects\tO\nagainst\tO\nseizures\tB-Disease\n,\tO\nlearning\tB-Disease\nand\tI-Disease\nmemory\tI-Disease\nimpairments\tI-Disease\nand\tO\noxidative\tO\ndamage\tO\ninduced\tO\nby\tO\npentylenetetrazole\tB-Chemical\n-\tO\ninduced\tO\nkindling\tO\nin\tO\nmice\tO\n.\tO\n\nCognitive\tB-Disease\nimpairment\tI-Disease\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nand\tO\nsevere\tO\ncomorbidity\tO\nof\tO\nepilepsy\tB-Disease\n,\tO\ngreatly\tO\ndiminishes\tO\nthe\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nHowever\tO\n,\tO\ncurrent\tO\ntherapeutic\tO\ninterventions\tO\nfor\tO\nepilepsy\tB-Disease\ncan\tO\nalso\tO\ncause\tO\nuntoward\tO\ncognitive\tO\neffects\tO\n.\tO\n\nThus\tO\n,\tO\nthere\tO\nis\tO\nan\tO\nurgent\tO\nneed\tO\nfor\tO\nnew\tO\nkinds\tO\nof\tO\nagents\tO\ntargeting\tO\nboth\tO\nseizures\tB-Disease\nand\tO\ncognition\tB-Disease\ndeficits\tI-Disease\n.\tO\n\nOxidative\tO\nstress\tO\nis\tO\nconsidered\tO\nto\tO\nplay\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nepileptogenesis\tO\nand\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\n,\tO\nand\tO\nantioxidants\tO\nhave\tO\na\tO\nputative\tO\nantiepileptic\tO\npotential\tO\n.\tO\n\nMetformin\tB-Chemical\n,\tO\nthe\tO\nmost\tO\ncommonly\tO\nprescribed\tO\nantidiabetic\tO\noral\tO\ndrug\tO\n,\tO\nhas\tO\nantioxidant\tO\nproperties\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\nthe\tO\nameliorative\tO\neffects\tO\nof\tO\nmetformin\tB-Chemical\non\tO\nseizures\tB-Disease\n,\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\nand\tO\nbrain\tO\noxidative\tO\nstress\tO\nmarkers\tO\nobserved\tO\nin\tO\npentylenetetrazole\tB-Chemical\n-\tO\ninduced\tO\nkindling\tO\nanimals\tO\n.\tO\n\nMale\tO\nC57BL\tO\n/\tO\n6\tO\nmice\tO\nwere\tO\nadministered\tO\nwith\tO\nsubconvulsive\tO\ndose\tO\nof\tO\npentylenetetrazole\tB-Chemical\n(\tO\n37\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nevery\tO\nother\tO\nday\tO\nfor\tO\n14\tO\ninjections\tO\n.\tO\n\nMetformin\tB-Chemical\nwas\tO\ninjected\tO\nintraperitoneally\tO\nin\tO\ndose\tO\nof\tO\n200mg\tO\n/\tO\nkg\tO\nalong\tO\nwith\tO\nalternate\tO\n-\tO\nday\tO\nPTZ\tB-Chemical\n.\tO\n\nWe\tO\nfound\tO\nthat\tO\nmetformin\tB-Chemical\nsuppressed\tO\nthe\tO\nprogression\tO\nof\tO\nkindling\tO\n,\tO\nameliorated\tO\nthe\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\nand\tO\ndecreased\tO\nbrain\tO\noxidative\tO\nstress\tO\n.\tO\n\nThus\tO\nthe\tO\npresent\tO\nstudy\tO\nconcluded\tO\nthat\tO\nmetformin\tB-Chemical\nmay\tO\nbe\tO\na\tO\npotential\tO\nagent\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nepilepsy\tB-Disease\nas\tO\nwell\tO\nas\tO\na\tO\nprotective\tO\nmedicine\tO\nagainst\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\ninduced\tO\nby\tO\nseizures\tB-Disease\n.\tO\n\nP53\tO\ninhibition\tO\nexacerbates\tO\nlate\tO\n-\tO\nstage\tO\nanthracycline\tB-Chemical\ncardiotoxicity\tB-Disease\n.\tO\n\nAIMS\tO\n:\tO\nDoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\nis\tO\nan\tO\neffective\tO\nanti\tO\n-\tO\ncancer\tB-Disease\ntherapeutic\tO\n,\tO\nbut\tO\nis\tO\nassociated\tO\nwith\tO\nboth\tO\nacute\tO\nand\tO\nlate\tO\n-\tO\nstage\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nChildren\tO\nare\tO\nparticularly\tO\nsensitive\tO\nto\tO\nDOX\tB-Chemical\n-\tO\ninduced\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nHere\tO\n,\tO\nthe\tO\nimpact\tO\nof\tO\np53\tO\ninhibition\tO\non\tO\nacute\tO\nvs\tO\n.\tO\nlate\tO\n-\tO\nstage\tO\nDOX\tB-Chemical\ncardiotoxicity\tB-Disease\nwas\tO\nexamined\tO\nin\tO\na\tO\njuvenile\tO\nmodel\tO\n.\tO\n\nMETHODS\tO\nAND\tO\nRESULTS\tO\n:\tO\nTwo\tO\n-\tO\nweek\tO\n-\tO\nold\tO\nMHC\tO\n-\tO\nCB7\tO\nmice\tO\n(\tO\nwhich\tO\nexpress\tO\ndominant\tO\n-\tO\ninterfering\tO\np53\tO\nin\tO\ncardiomyocytes\tO\n)\tO\nand\tO\ntheir\tO\nnon\tO\n-\tO\ntransgenic\tO\n(\tO\nNON\tO\n-\tO\nTXG\tO\n)\tO\nlittermates\tO\nreceived\tO\nweekly\tO\nDOX\tB-Chemical\ninjections\tO\nfor\tO\n5\tO\nweeks\tO\n(\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\ncumulative\tO\ndose\tO\n)\tO\n.\tO\n\nOne\tO\nweek\tO\nafter\tO\nthe\tO\nlast\tO\nDOX\tB-Chemical\ntreatment\tO\n(\tO\nacute\tO\nstage\tO\n)\tO\n,\tO\nMHC\tO\n-\tO\nCB7\tO\nmice\tO\nexhibited\tO\nimproved\tO\ncardiac\tO\nfunction\tO\nand\tO\nlower\tO\nlevels\tO\nof\tO\ncardiomyocyte\tO\napoptosis\tO\nwhen\tO\ncompared\tO\nwith\tO\nthe\tO\nNON\tO\n-\tO\nTXG\tO\nmice\tO\n.\tO\n\nSurprisingly\tO\n,\tO\nby\tO\n13\tO\nweeks\tO\nfollowing\tO\nthe\tO\nlast\tO\nDOX\tB-Chemical\ntreatment\tO\n(\tO\nlate\tO\nstage\tO\n)\tO\n,\tO\nMHC\tO\n-\tO\nCB7\tO\nexhibited\tO\na\tO\nprogressive\tO\ndecrease\tO\nin\tO\ncardiac\tO\nfunction\tO\nand\tO\nhigher\tO\nrates\tO\nof\tO\ncardiomyocyte\tO\napoptosis\tO\nwhen\tO\ncompared\tO\nwith\tO\nNON\tO\n-\tO\nTXG\tO\nmice\tO\n.\tO\n\np53\tO\ninhibition\tO\nblocked\tO\ntransient\tO\nDOX\tB-Chemical\n-\tO\ninduced\tO\nSTAT3\tO\nactivation\tO\nin\tO\nMHC\tO\n-\tO\nCB7\tO\nmice\tO\n,\tO\nwhich\tO\nwas\tO\nassociated\tO\nwith\tO\nenhanced\tO\ninduction\tO\nof\tO\nthe\tO\nDNA\tO\nrepair\tO\nproteins\tO\nKu70\tO\nand\tO\nKu80\tO\n.\tO\n\nMice\tO\nwith\tO\ncardiomyocyte\tO\n-\tO\nrestricted\tO\ndeletion\tO\nof\tO\nSTAT3\tO\nexhibited\tO\nworse\tO\ncardiac\tO\nfunction\tO\n,\tO\nhigher\tO\nlevels\tO\nof\tO\ncardiomyocyte\tO\napoptosis\tO\n,\tO\nand\tO\na\tO\ngreater\tO\ninduction\tO\nof\tO\nKu70\tO\nand\tO\nKu80\tO\nin\tO\nresponse\tO\nto\tO\nDOX\tB-Chemical\ntreatment\tO\nduring\tO\nthe\tO\nacute\tO\nstage\tO\nwhen\tO\ncompared\tO\nwith\tO\ncontrol\tO\nanimals\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThese\tO\ndata\tO\nsupport\tO\na\tO\nmodel\tO\nwherein\tO\na\tO\np53\tO\n-\tO\ndependent\tO\ncardioprotective\tO\npathway\tO\n,\tO\nmediated\tO\nvia\tO\nSTAT3\tO\nactivation\tO\n,\tO\nmitigates\tO\nDOX\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tO\nstress\tO\nduring\tO\ndrug\tO\ndelivery\tO\n.\tO\n\nFurthermore\tO\n,\tO\nthese\tO\ndata\tO\nsuggest\tO\nan\tO\nexplanation\tO\nas\tO\nto\tO\nhow\tO\np53\tO\ninhibition\tO\ncan\tO\nresult\tO\nin\tO\ncardioprotection\tO\nduring\tO\ndrug\tO\ntreatment\tO\nand\tO\n,\tO\nparadoxically\tO\n,\tO\nenhanced\tO\ncardiotoxicity\tB-Disease\nlong\tO\nafter\tO\nthe\tO\ncessation\tO\nof\tO\ndrug\tO\ntreatment\tO\n.\tO\n\nMetronidazole\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\n:\tO\nan\tO\nuncommon\tO\nscenario\tO\n.\tO\n\nMetronidazole\tB-Chemical\ncan\tO\nproduce\tO\nneurological\tO\ncomplications\tO\nalthough\tO\nit\tO\nis\tO\nnot\tO\na\tO\ncommon\tO\nscenario\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\ncase\tO\nwhere\tO\na\tO\npatient\tO\ndeveloped\tO\nfeatures\tO\nof\tO\nencephalopathy\tB-Disease\nfollowing\tO\nprolonged\tO\nmetronidazole\tB-Chemical\nintake\tO\n.\tO\n\nMagnetic\tO\nresonance\tO\nimaging\tO\n(\tO\nMRI\tO\n)\tO\nbrain\tO\nshowed\tO\nabnormal\tO\nsignal\tO\nintensity\tO\ninvolving\tO\nboth\tO\ndentate\tO\nnuclei\tO\nof\tO\ncerebellum\tO\nand\tO\nsplenium\tO\nof\tO\ncorpus\tO\ncallosum\tO\n.\tO\n\nThe\tO\ndiagnosis\tO\nof\tO\nmetronidazole\tB-Chemical\ntoxicity\tB-Disease\nwas\tO\nmade\tO\nby\tO\nthe\tO\nMRI\tO\nfindings\tO\nand\tO\nsupported\tO\nclinically\tO\n.\tO\n\nAconitine\tB-Chemical\n-\tO\ninduced\tO\nCa2\tB-Chemical\n+\tO\noverload\tO\ncauses\tO\narrhythmia\tB-Disease\nand\tO\ntriggers\tO\napoptosis\tO\nthrough\tO\np38\tO\nMAPK\tO\nsignaling\tO\npathway\tO\nin\tO\nrats\tO\n.\tO\n\nAconitine\tB-Chemical\nis\tO\na\tO\nmajor\tO\nbioactive\tO\nditerpenoid\tO\nalkaloid\tO\nwith\tO\nhigh\tO\ncontent\tO\nderived\tO\nfrom\tO\nherbal\tO\naconitum\tO\nplants\tO\n.\tO\n\nEmerging\tO\nevidence\tO\nindicates\tO\nthat\tO\nvoltage\tO\n-\tO\ndependent\tO\nNa\tB-Chemical\n(\tO\n+\tO\n)\tO\nchannels\tO\nhave\tO\npivotal\tO\nroles\tO\nin\tO\nthe\tO\ncardiotoxicity\tB-Disease\nof\tO\naconitine\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nno\tO\nreports\tO\nare\tO\navailable\tO\non\tO\nthe\tO\nrole\tO\nof\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nin\tO\naconitine\tB-Chemical\npoisoning\tB-Disease\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\nimportance\tO\nof\tO\npathological\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nsignaling\tO\nin\tO\naconitine\tB-Chemical\npoisoning\tB-Disease\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\n.\tO\n\nWe\tO\nfound\tO\nthat\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\noverload\tO\nlead\tO\nto\tO\naccelerated\tO\nbeating\tO\nrhythm\tO\nin\tO\nadult\tO\nrat\tO\nventricular\tO\nmyocytes\tO\nand\tO\ncaused\tO\narrhythmia\tB-Disease\nin\tO\nconscious\tO\nfreely\tO\nmoving\tO\nrats\tO\n.\tO\n\nTo\tO\ninvestigate\tO\neffects\tO\nof\tO\naconitine\tB-Chemical\non\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\n,\tO\nwe\tO\nperformed\tO\ncytotoxicity\tB-Disease\nassay\tO\nin\tO\nneonatal\tO\nrat\tO\nventricular\tO\nmyocytes\tO\n(\tO\nNRVMs\tO\n)\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nmeasured\tO\nlactate\tB-Chemical\ndehydrogenase\tO\nlevel\tO\nin\tO\nthe\tO\nculture\tO\nmedium\tO\nof\tO\nNRVMs\tO\nand\tO\nactivities\tO\nof\tO\nserum\tO\ncardiac\tO\nenzymes\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nresults\tO\nshowed\tO\nthat\tO\naconitine\tB-Chemical\nresulted\tO\nin\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\nand\tO\nreduced\tO\nNRVMs\tO\nviability\tO\ndose\tO\n-\tO\ndependently\tO\n.\tO\n\nTo\tO\nconfirm\tO\nthe\tO\npro\tO\n-\tO\napoptotic\tO\neffects\tO\n,\tO\nwe\tO\nperformed\tO\nflow\tO\ncytometric\tO\ndetection\tO\n,\tO\ncardiac\tO\nhistology\tO\n,\tO\ntransmission\tO\nelectron\tO\nmicroscopy\tO\nand\tO\nterminal\tO\ndeoxynucleotidyl\tO\ntransferase\tO\n-\tO\nmediated\tO\ndUTP\tB-Chemical\n-\tO\nbiotin\tB-Chemical\nnick\tO\nend\tO\nlabeling\tO\nassay\tO\n.\tO\n\nThe\tO\nresults\tO\nshowed\tO\nthat\tO\naconitine\tB-Chemical\nstimulated\tO\napoptosis\tO\ntime\tO\n-\tO\ndependently\tO\n.\tO\n\nThe\tO\nexpression\tO\nanalysis\tO\nof\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nhandling\tO\nproteins\tO\ndemonstrated\tO\nthat\tO\naconitine\tB-Chemical\npromoted\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\noverload\tO\nthrough\tO\nthe\tO\nexpression\tO\nregulation\tO\nof\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\nhandling\tO\nproteins\tO\n.\tO\n\nThe\tO\nexpression\tO\nanalysis\tO\nof\tO\napoptosis\tO\n-\tO\nrelated\tO\nproteins\tO\nrevealed\tO\nthat\tO\npro\tO\n-\tO\napoptotic\tO\nprotein\tO\nexpression\tO\nwas\tO\nupregulated\tO\n,\tO\nand\tO\nanti\tO\n-\tO\napoptotic\tO\nprotein\tO\nBCL\tO\n-\tO\n2\tO\nexpression\tO\nwas\tO\ndownregulated\tO\n.\tO\n\nFurthermore\tO\n,\tO\nincreased\tO\nphosphorylation\tO\nof\tO\nMAPK\tO\nfamily\tO\nmembers\tO\n,\tO\nespecially\tO\nthe\tO\nP\tO\n-\tO\nP38\tO\n/\tO\nP38\tO\nratio\tO\nwas\tO\nfound\tO\nin\tO\ncardiac\tO\ntissues\tO\n.\tO\n\nHence\tO\n,\tO\nour\tO\nresults\tO\nsuggest\tO\nthat\tO\naconitine\tB-Chemical\nsignificantly\tO\naggravates\tO\nCa\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\noverload\tO\nand\tO\ncauses\tO\narrhythmia\tB-Disease\nand\tO\nfinally\tO\npromotes\tO\napoptotic\tO\ndevelopment\tO\nvia\tO\nphosphorylation\tO\nof\tO\nP38\tO\nmitogen\tO\n-\tO\nactivated\tO\nprotein\tO\nkinase\tO\n.\tO\n\nChronic\tO\ntreatment\tO\nwith\tO\nmetformin\tB-Chemical\nsuppresses\tO\ntoll\tO\n-\tO\nlike\tO\nreceptor\tO\n4\tO\nsignaling\tO\nand\tO\nattenuates\tO\nleft\tB-Disease\nventricular\tI-Disease\ndysfunction\tI-Disease\nfollowing\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nAcute\tO\ntreatment\tO\nwith\tO\nmetformin\tB-Chemical\nhas\tO\na\tO\nprotective\tO\neffect\tO\nin\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nby\tO\nsuppression\tO\nof\tO\ninflammatory\tO\nresponses\tO\ndue\tO\nto\tO\nactivation\tO\nof\tO\nAMP\tB-Chemical\n-\tO\nactivated\tO\nprotein\tO\nkinase\tO\n(\tO\nAMPK\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthe\tO\neffect\tO\nof\tO\nchronic\tO\npre\tO\n-\tO\ntreatment\tO\nwith\tO\nmetformin\tB-Chemical\non\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\nand\tO\ntoll\tO\n-\tO\nlike\tO\nreceptor\tO\n4\tO\n(\tO\nTLR4\tO\n)\tO\nactivities\tO\nfollowing\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nand\tO\ntheir\tO\nrelation\tO\nwith\tO\nAMPK\tO\nwere\tO\nassessed\tO\n.\tO\n\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\none\tO\nof\tO\n5\tO\ngroups\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\n:\tO\nnormal\tO\ncontrol\tO\nand\tO\ngroups\tO\nwere\tO\ninjected\tO\nisoproterenol\tB-Chemical\nafter\tO\nchronic\tO\npre\tO\n-\tO\ntreatment\tO\nwith\tO\n0\tO\n,\tO\n25\tO\n,\tO\n50\tO\n,\tO\nor\tO\n100mg\tO\n/\tO\nkg\tO\nof\tO\nmetformin\tB-Chemical\ntwice\tO\ndaily\tO\nfor\tO\n14\tO\ndays\tO\n.\tO\n\nIsoproterenol\tB-Chemical\n(\tO\n100mg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ninjected\tO\nsubcutaneously\tO\non\tO\nthe\tO\n13th\tO\nand\tO\n14th\tO\ndays\tO\nto\tO\ninduce\tO\nacute\tB-Disease\nmyocardial\tI-Disease\ninfarction\tI-Disease\n.\tO\n\nIsoproterenol\tB-Chemical\nalone\tO\ndecreased\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nand\tO\nmyocardial\tO\ncontractility\tO\nindexed\tO\nas\tO\nLVdp\tO\n/\tO\ndtmax\tO\nand\tO\nLVdp\tO\n/\tO\ndtmin\tO\n.\tO\n\nThe\tO\nleft\tB-Disease\nventricular\tI-Disease\ndysfunction\tI-Disease\nwas\tO\nsignificantly\tO\nlower\tO\nin\tO\nthe\tO\ngroups\tO\ntreated\tO\nwith\tO\n25\tO\nand\tO\n50mg\tO\n/\tO\nkg\tO\nof\tO\nmetformin\tB-Chemical\n.\tO\n\nMetfromin\tO\nmarkedly\tO\nlowered\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nelevation\tO\nin\tO\nthe\tO\nlevels\tO\nof\tO\nTLR4\tO\nmRNA\tO\n,\tO\nmyeloid\tO\ndifferentiation\tO\nprotein\tO\n88\tO\n(\tO\nMyD88\tO\n)\tO\n,\tO\ntumor\tB-Disease\nnecrosis\tB-Disease\nfactor\tO\n-\tO\nalpha\tO\n(\tO\nTNF\tO\n-\tO\na\tO\n)\tO\n,\tO\nand\tO\ninterleukin\tO\n6\tO\n(\tO\nIL\tO\n-\tO\n6\tO\n)\tO\nin\tO\nthe\tO\nheart\tO\ntissues\tO\n.\tO\n\nSimilar\tO\nchanges\tO\nwere\tO\nalso\tO\nseen\tO\nin\tO\nthe\tO\nserum\tO\nlevels\tO\nof\tO\nTNF\tO\n-\tO\na\tO\nand\tO\nIL\tO\n-\tO\n6\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nlower\tO\ndoses\tO\nof\tO\n25\tO\nand\tO\n50mg\tO\n/\tO\nkg\tO\nwere\tO\nmore\tO\neffective\tO\nthan\tO\n100mg\tO\n/\tO\nkg\tO\n.\tO\n\nPhosphorylated\tO\nAMPKa\tO\n(\tO\np\tO\n-\tO\nAMPK\tO\n)\tO\nin\tO\nthe\tO\nmyocardium\tO\nwas\tO\nsignificantly\tO\nelevated\tO\nby\tO\n25mg\tO\n/\tO\nkg\tO\nof\tO\nmetformin\tB-Chemical\n,\tO\nslightly\tO\nby\tO\n50mg\tO\n/\tO\nkg\tO\n,\tO\nbut\tO\nnot\tO\nby\tO\n100mg\tO\n/\tO\nkg\tO\n.\tO\n\nChronic\tO\npre\tO\n-\tO\ntreatment\tO\nwith\tO\nmetformin\tB-Chemical\nreduces\tO\npost\tO\n-\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\ncardiac\tO\ndysfunction\tO\nand\tO\nsuppresses\tO\ninflammatory\tO\nresponses\tO\n,\tO\npossibly\tO\nthrough\tO\ninhibition\tO\nof\tO\nTLR4\tO\nactivities\tO\n.\tO\n\nThis\tO\nmechanism\tO\ncan\tO\nbe\tO\nconsidered\tO\nas\tO\na\tO\ntarget\tO\nto\tO\nprotect\tO\ninfarcted\tO\nmyocardium\tO\n.\tO\n\nUnusual\tO\ncomplications\tO\nof\tO\nantithyroid\tO\ndrug\tO\ntherapy\tO\n:\tO\nfour\tO\ncase\tO\nreports\tO\nand\tO\nreview\tO\nof\tO\nliterature\tO\n.\tO\n\nTwo\tO\ncases\tO\nof\tO\npropylthiouracil\tB-Chemical\n-\tO\nassociated\tO\nacute\tO\nhepatitis\tB-Disease\n,\tO\none\tO\ncase\tO\nof\tO\nfatal\tO\nmethimazole\tB-Chemical\n-\tO\nassociated\tO\nhepatocellular\tB-Disease\nnecrosis\tI-Disease\nand\tO\none\tO\ncase\tO\nof\tO\npropylthiouracil\tB-Chemical\n-\tO\nassociated\tO\nlupus\tB-Disease\n-\tI-Disease\nlike\tI-Disease\nsyndrome\tI-Disease\nare\tO\ndescribed\tO\n.\tO\n\nThe\tO\nliterature\tO\nrelated\tO\nto\tO\nantithyroid\tO\ndrug\tO\nside\tO\neffects\tO\nand\tO\nthe\tO\nmechanisms\tO\nfor\tO\ntheir\tO\noccurrence\tO\nare\tO\nreviewed\tO\nand\tO\nthe\tO\nefficacy\tO\nand\tO\ncomplications\tO\nof\tO\nthyroidectomy\tO\nand\tO\nradioiodine\tO\ncompared\tO\nto\tO\nthose\tO\nof\tO\nantithyroid\tO\ndrugs\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nin\tO\nmost\tO\ncircumstances\tO\n131I\tO\nis\tO\nthe\tO\ntherapy\tO\nof\tO\nchoice\tO\nfor\tO\nhyperthyroidism\tB-Disease\n.\tO\n\nNeuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\ninduced\tO\nby\tO\ncombination\tO\ntherapy\tO\nwith\tO\ntetrabenazine\tB-Chemical\nand\tO\ntiapride\tB-Chemical\nin\tO\na\tO\nJapanese\tO\npatient\tO\nwith\tO\nHuntington\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nat\tO\nthe\tO\nterminal\tO\nstage\tO\nof\tO\nrecurrent\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nWe\tO\nherein\tO\ndescribe\tO\nthe\tO\ncase\tO\nof\tO\nan\tO\n81\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nJapanese\tO\nwoman\tO\nwith\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nthat\tO\noccurred\tO\n36\tO\ndays\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\ncombination\tO\ntherapy\tO\nwith\tO\ntiapride\tB-Chemical\n(\tO\n75\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nand\tO\ntetrabenazine\tB-Chemical\n(\tO\n12\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nfor\tO\nHuntington\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nThe\tO\npatient\tO\nhad\tO\nbeen\tO\ntreated\tO\nwith\tO\ntiapride\tB-Chemical\nor\tO\ntetrabenazine\tB-Chemical\nalone\tO\nwithout\tO\nany\tO\nadverse\tO\neffects\tO\nbefore\tO\nthe\tO\nadministration\tO\nof\tO\nthe\tO\ncombination\tO\ntherapy\tO\n.\tO\n\nShe\tO\nalso\tO\nhad\tO\nadvanced\tO\nbreast\tB-Disease\ncancer\tI-Disease\nwhen\tO\nthe\tO\ncombination\tO\ntherapy\tO\nwas\tO\ninitiated\tO\n.\tO\n\nTo\tO\nthe\tO\nbest\tO\nof\tO\nour\tO\nknowledge\tO\n,\tO\nthe\tO\noccurrence\tO\nof\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\ndue\tO\nto\tO\ncombination\tO\ntherapy\tO\nwith\tO\ntetrabenazine\tB-Chemical\nand\tO\ntiapride\tB-Chemical\nhas\tO\nnot\tO\nbeen\tO\npreviously\tO\nreported\tO\n.\tO\n\nTetrabenazine\tB-Chemical\nshould\tO\nbe\tO\nadministered\tO\nvery\tO\ncarefully\tO\nin\tO\ncombination\tO\nwith\tO\nother\tO\nneuroleptic\tB-Chemical\ndrugs\tI-Chemical\n,\tO\nparticularly\tO\nin\tO\npatients\tO\nwith\tO\na\tO\nworsening\tO\ngeneral\tO\ncondition\tO\n.\tO\n\nA\tO\nmetoprolol\tB-Chemical\n-\tO\nterbinafine\tB-Chemical\ncombination\tO\ninduced\tO\nbradycardia\tB-Disease\n.\tO\n\nTo\tO\nreport\tO\na\tO\nsinus\tB-Disease\nbradycardia\tI-Disease\ninduced\tO\nby\tO\nmetoprolol\tB-Chemical\nand\tO\nterbinafine\tB-Chemical\ndrug\tO\n-\tO\ndrug\tO\ninteraction\tO\nand\tO\nits\tO\nmanagement\tO\n.\tO\n\nA\tO\n63\tO\nyear\tO\n-\tO\nold\tO\nCaucasian\tO\nman\tO\non\tO\nmetoprolol\tB-Chemical\n200\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\nstable\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nwas\tO\nprescribed\tO\na\tO\n90\tO\n-\tO\nday\tO\ncourse\tO\nof\tO\noral\tO\nterbinafine\tB-Chemical\n250\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\nonychomycosis\tB-Disease\n.\tO\n\nOn\tO\nthe\tO\n49th\tO\nday\tO\nof\tO\nterbinafine\tB-Chemical\ntherapy\tO\n,\tO\nhe\tO\nwas\tO\nbrought\tO\nto\tO\nthe\tO\nemergency\tO\nroom\tO\nfor\tO\na\tO\ndecrease\tO\nof\tO\nhis\tO\nglobal\tO\nhealth\tO\nstatus\tO\n,\tO\nconfusion\tB-Disease\nand\tO\nfalls\tO\n.\tO\n\nThe\tO\nelectrocardiogram\tO\nrevealed\tO\na\tO\n37\tO\nbeats\tO\n/\tO\nmin\tO\nsinus\tB-Disease\nbradycardia\tI-Disease\n.\tO\n\nA\tO\nscore\tO\nof\tO\n7\tO\non\tO\nthe\tO\nNaranjo\tO\nadverse\tB-Disease\ndrug\tI-Disease\nreaction\tI-Disease\nprobability\tO\nscale\tO\nindicates\tO\na\tO\nprobable\tO\nrelationship\tO\nbetween\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nsinus\tB-Disease\nbradycardia\tI-Disease\nand\tO\nthe\tO\ndrug\tO\ninteraction\tO\nbetween\tO\nmetoprolol\tB-Chemical\nand\tO\nterbinafine\tB-Chemical\n.\tO\n\nThe\tO\nheart\tO\nrate\tO\nameliorated\tO\nfirst\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\nthe\tO\ndose\tO\nof\tO\nmetoprolol\tB-Chemical\n.\tO\n\nIt\tO\nwas\tO\nsubsequently\tO\nchanged\tO\nto\tO\nbisoprolol\tB-Chemical\nand\tO\nthe\tO\nheart\tO\nrate\tO\nremained\tO\nnormal\tO\n.\tO\n\nBy\tO\ninhibiting\tO\nthe\tO\ncytochrome\tO\nP450\tO\n2D6\tO\n,\tO\nterbinafine\tB-Chemical\nhad\tO\ndecreased\tO\nmetoprolol\tB-Chemical\n'\tO\ns\tO\nclearance\tO\n,\tO\nleading\tO\nin\tO\nmetoprolol\tB-Chemical\naccumulation\tO\nwhich\tO\nhas\tO\nresulted\tO\nin\tO\nclinically\tO\nsignificant\tO\nsinus\tB-Disease\nbradycardia\tI-Disease\n.\tO\n\nOptochiasmatic\tO\nand\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\ndue\tO\nto\tO\nethambutol\tB-Chemical\novertreatment\tO\n.\tO\n\nEthambutol\tB-Chemical\nis\tO\nknown\tO\nto\tO\ncause\tO\noptic\tB-Disease\nneuropathy\tI-Disease\nand\tO\n,\tO\nmore\tO\nrarely\tO\n,\tO\naxonal\tO\npolyneuropathy\tB-Disease\n.\tO\n\nWe\tO\ncharacterize\tO\nthe\tO\nclinical\tO\n,\tO\nneurophysiological\tO\n,\tO\nand\tO\nneuroimaging\tO\nfindings\tO\nin\tO\na\tO\n72\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\ndeveloped\tO\nvisual\tB-Disease\nloss\tI-Disease\nand\tO\nparesthesias\tB-Disease\nafter\tO\n11\tO\nweeks\tO\nof\tO\nexposure\tO\nto\tO\na\tO\nsupratherapeutic\tO\ndose\tO\nof\tO\nethambutol\tB-Chemical\n.\tO\n\nThis\tO\ncase\tO\ndemonstrates\tO\nthe\tO\nselective\tO\nvulnerability\tO\nof\tO\nthe\tO\nanterior\tO\nvisual\tO\npathways\tO\nand\tO\nperipheral\tO\nnerves\tO\nto\tO\nethambutol\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nTestosterone\tB-Chemical\nameliorates\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\nmemory\tB-Disease\nimpairment\tI-Disease\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nAIM\tO\n:\tO\nTo\tO\nstudy\tO\nthe\tO\neffects\tO\nof\tO\ntestosterone\tB-Chemical\non\tO\nstreptozotocin\tB-Chemical\n(\tO\nSTZ\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nmemory\tB-Disease\nimpairment\tI-Disease\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nMETHODS\tO\n:\tO\nAdult\tO\nmale\tO\nWistar\tO\nrats\tO\nwere\tO\nintracerebroventricularly\tO\n(\tO\nicv\tO\n)\tO\ninfused\tO\nwith\tO\nSTZ\tB-Chemical\n(\tO\n750\tO\nug\tO\n)\tO\non\tO\nd\tO\n1\tO\nand\tO\nd\tO\n3\tO\n,\tO\nand\tO\na\tO\npassive\tO\navoidance\tO\ntask\tO\nwas\tO\nassessed\tO\n2\tO\nweeks\tO\nafter\tO\nthe\tO\nfirst\tO\ninjection\tO\nof\tO\nSTZ\tB-Chemical\n.\tO\n\nCastration\tO\nsurgery\tO\nwas\tO\nperformed\tO\nin\tO\nanother\tO\ngroup\tO\nof\tO\nrats\tO\n,\tO\nand\tO\nthe\tO\npassive\tO\navoidance\tO\ntask\tO\nwas\tO\nassessed\tO\n4\tO\nweeks\tO\nafter\tO\nthe\tO\noperation\tO\n.\tO\n\nTestosterone\tB-Chemical\n(\tO\n1\tO\nmg\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\nd\tO\n(\tO\n-\tO\n1\tO\n)\tO\n,\tO\nsc\tO\n)\tO\n,\tO\nthe\tO\nandrogen\tB-Chemical\nreceptor\tO\nantagonist\tO\nflutamide\tB-Chemical\n(\tO\n10\tO\nmg\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\nd\tO\n(\tO\n-\tO\n1\tO\n)\tO\n,\tO\nip\tO\n)\tO\n,\tO\nthe\tO\nestrogen\tB-Chemical\nreceptor\tO\nantagonist\tO\ntamoxifen\tB-Chemical\n(\tO\n1\tO\nmg\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\nd\tO\n(\tO\n-\tO\n1\tO\n)\tO\n,\tO\nip\tO\n)\tO\nor\tO\nthe\tO\naromatase\tO\ninhibitor\tO\nletrozole\tB-Chemical\n(\tO\n4\tO\nmg\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\nd\tO\n(\tO\n-\tO\n1\tO\n)\tO\n,\tO\nip\tO\n)\tO\nwere\tO\nadministered\tO\nfor\tO\n6\tO\nd\tO\nafter\tO\nthe\tO\nfirst\tO\ninjection\tO\nof\tO\nSTZ\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nSTZ\tB-Chemical\nadministration\tO\nand\tO\ncastration\tO\nmarkedly\tO\ndecreased\tO\nboth\tO\nSTL1\tO\n(\tO\nthe\tO\nshort\tO\nmemory\tO\n)\tO\nand\tO\nSTL2\tO\n(\tO\nthe\tO\nlong\tO\nmemory\tO\n)\tO\nin\tO\npassive\tO\navoidance\tO\ntests\tO\n.\tO\n\nTestosterone\tB-Chemical\nreplacement\tO\nalmost\tO\nrestored\tO\nthe\tO\nSTL1\tO\nand\tO\nSTL2\tO\nin\tO\ncastrated\tO\nrats\tO\n,\tO\nand\tO\nsignificantly\tO\nprolonged\tO\nthe\tO\nSTL1\tO\nand\tO\nSTL2\tO\nin\tO\nSTZ\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nAdministration\tO\nof\tO\nflutamide\tB-Chemical\n,\tO\nletrozole\tB-Chemical\nor\tO\ntamoxifen\tB-Chemical\nsignificantly\tO\nimpaired\tB-Disease\nthe\tI-Disease\nmemory\tI-Disease\nin\tO\nintact\tO\nrats\tO\n,\tO\nand\tO\nsignificantly\tO\nattenuated\tO\nthe\tO\ntestosterone\tB-Chemical\nreplacement\tO\nin\tO\nimproving\tO\nSTZ\tB-Chemical\n-\tO\nand\tO\ncastration\tO\n-\tO\ninduced\tO\nmemory\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nTestosterone\tB-Chemical\nadministration\tO\nameliorates\tO\nSTZ\tB-Chemical\n-\tO\nand\tO\ncastration\tO\n-\tO\ninduced\tO\nmemory\tB-Disease\nimpairment\tI-Disease\nin\tO\nmale\tO\nWistar\tO\nrats\tO\n.\tO\n\nBehavioral\tO\nand\tO\nneurochemical\tO\nstudies\tO\nin\tO\nmice\tO\npretreated\tO\nwith\tO\ngarcinielliptone\tB-Chemical\nFC\tI-Chemical\nin\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nGarcinielliptone\tB-Chemical\nFC\tI-Chemical\n(\tO\nGFC\tB-Chemical\n)\tO\nisolated\tO\nfrom\tO\nhexanic\tO\nfraction\tO\nseed\tO\nextract\tO\nof\tO\nspecies\tO\nPlatonia\tO\ninsignis\tO\nMart\tO\n.\tO\n\nIt\tO\nis\tO\nwidely\tO\nused\tO\nin\tO\nfolk\tO\nmedicine\tO\nto\tO\ntreat\tO\nskin\tB-Disease\ndiseases\tI-Disease\nin\tO\nboth\tO\nhumans\tO\nand\tO\nanimals\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\nseed\tO\ndecoction\tO\nhas\tO\nbeen\tO\nused\tO\nto\tO\ntreat\tO\ndiarrheas\tB-Disease\nand\tO\ninflammatory\tB-Disease\ndiseases\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nis\tO\nno\tO\nresearch\tO\non\tO\nGFC\tB-Chemical\neffects\tO\nin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\nof\tO\nrodents\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\naimed\tO\nto\tO\nevaluate\tO\nthe\tO\nGFC\tB-Chemical\neffects\tO\nat\tO\ndoses\tO\nof\tO\n25\tO\n,\tO\n50\tO\nor\tO\n75\tO\nmg\tO\n/\tO\nkg\tO\non\tO\nseizure\tB-Disease\nparameters\tO\nto\tO\ndetermine\tO\ntheir\tO\nanticonvulsant\tO\nactivity\tO\nand\tO\nits\tO\neffects\tO\non\tO\namino\tB-Chemical\nacid\tI-Chemical\n(\tO\nr\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n(\tO\nGABA\tB-Chemical\n)\tO\n,\tO\nglutamine\tB-Chemical\n,\tO\naspartate\tB-Chemical\nand\tO\nglutathione\tB-Chemical\n)\tO\nlevels\tO\nas\tO\nwell\tO\nas\tO\non\tO\nacetylcholinesterase\tO\n(\tO\nAChE\tO\n)\tO\nactivity\tO\nin\tO\nmice\tO\nhippocampus\tO\nafter\tO\nseizures\tB-Disease\n.\tO\n\nGFC\tB-Chemical\nproduced\tO\nan\tO\nincreased\tO\nlatency\tO\nto\tO\nfirst\tO\nseizure\tB-Disease\n,\tO\nat\tO\ndoses\tO\n25mg\tO\n/\tO\nkg\tO\n(\tO\n20\tO\n.\tO\n12\tO\n+\tO\n2\tO\n.\tO\n20\tO\nmin\tO\n)\tO\n,\tO\n50mg\tO\n/\tO\nkg\tO\n(\tO\n20\tO\n.\tO\n95\tO\n+\tO\n2\tO\n.\tO\n21\tO\nmin\tO\n)\tO\nor\tO\n75\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\n23\tO\n.\tO\n43\tO\n+\tO\n1\tO\n.\tO\n99\tO\nmin\tO\n)\tO\nwhen\tO\ncompared\tO\nwith\tO\nseized\tO\nmice\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nGABA\tB-Chemical\ncontent\tO\nof\tO\nmice\tO\nhippocampus\tO\ntreated\tO\nwith\tO\nGFC75\tO\nplus\tO\nP400\tO\nshowed\tO\nan\tO\nincrease\tO\nof\tO\n46\tO\n.\tO\n90\tO\n%\tO\nwhen\tO\ncompared\tO\nwith\tO\nseized\tO\nmice\tO\n.\tO\n\nIn\tO\naspartate\tB-Chemical\n,\tO\nglutamine\tB-Chemical\nand\tO\nglutamate\tB-Chemical\nlevels\tO\ndetected\tO\na\tO\ndecrease\tO\nof\tO\n5\tO\n.\tO\n21\tO\n%\tO\n,\tO\n13\tO\n.\tO\n55\tO\n%\tO\nand\tO\n21\tO\n.\tO\n80\tO\n%\tO\n,\tO\nrespectively\tO\nin\tO\nmice\tO\nhippocampus\tO\ntreated\tO\nwith\tO\nGFC75\tO\nplus\tO\nP400\tO\nwhen\tO\ncompared\tO\nwith\tO\nseized\tO\nmice\tO\n.\tO\n\nHippocampus\tO\nmice\tO\ntreated\tO\nwith\tO\nGFC75\tO\nplus\tO\nP400\tO\nshowed\tO\nan\tO\nincrease\tO\nin\tO\nAChE\tO\nactivity\tO\n(\tO\n63\tO\n.\tO\n30\tO\n%\tO\n)\tO\nwhen\tO\ncompared\tO\nwith\tO\nseized\tO\nmice\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nGFC\tB-Chemical\ncan\tO\nexert\tO\nanticonvulsant\tO\nactivity\tO\nand\tO\nreduce\tO\nthe\tO\nfrequency\tO\nof\tO\ninstallation\tO\nof\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n,\tO\nas\tO\ndemonstrated\tO\nby\tO\nincrease\tO\nin\tO\nlatency\tO\nto\tO\nfirst\tO\nseizure\tB-Disease\nand\tO\ndecrease\tO\nin\tO\nmortality\tO\nrate\tO\nof\tO\nanimals\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nour\tO\ndata\tO\nsuggest\tO\nthat\tO\nGFC\tB-Chemical\nmay\tO\ninfluence\tO\nin\tO\nepileptogenesis\tO\nand\tO\npromote\tO\nanticonvulsant\tO\nactions\tO\nin\tO\npilocarpine\tB-Chemical\nmodel\tO\nby\tO\nmodulating\tO\nthe\tO\nGABA\tB-Chemical\nand\tO\nglutamate\tB-Chemical\ncontents\tO\nand\tO\nof\tO\nAChE\tO\nactivity\tO\nin\tO\nseized\tO\nmice\tO\nhippocampus\tO\n.\tO\n\nThis\tO\ncompound\tO\nmay\tO\nbe\tO\nuseful\tO\nto\tO\nproduce\tO\nneuronal\tO\nprotection\tO\nand\tO\nit\tO\ncan\tO\nbe\tO\nconsidered\tO\nas\tO\nan\tO\nanticonvulsant\tO\nagent\tO\n.\tO\n\nStandard\tO\noperating\tO\nprocedures\tO\nfor\tO\nantibiotic\tO\ntherapy\tO\nand\tO\nthe\tO\noccurrence\tO\nof\tO\nacute\tB-Disease\nkidney\tI-Disease\ninjury\tI-Disease\n:\tO\na\tO\nprospective\tO\n,\tO\nclinical\tO\n,\tO\nnon\tO\n-\tO\ninterventional\tO\n,\tO\nobservational\tO\nstudy\tO\n.\tO\n\nINTRODUCTION\tO\n:\tO\nAcute\tB-Disease\nkidney\tI-Disease\ninjury\tI-Disease\n(\tO\nAKI\tB-Disease\n)\tO\noccurs\tO\nin\tO\n7\tO\n%\tO\nof\tO\nhospitalized\tO\nand\tO\n66\tO\n%\tO\nof\tO\nIntensive\tO\nCare\tO\nUnit\tO\n(\tO\nICU\tO\n)\tO\npatients\tO\n.\tO\n\nIt\tO\nincreases\tO\nmortality\tO\n,\tO\nhospital\tO\nlength\tO\nof\tO\nstay\tO\n,\tO\nand\tO\ncosts\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\n,\tO\nwhether\tO\nthere\tO\nis\tO\nan\tO\nassociation\tO\nbetween\tO\nadherence\tO\nto\tO\nguidelines\tO\n(\tO\nstandard\tO\noperating\tO\nprocedures\tO\n(\tO\nSOP\tO\n)\tO\n)\tO\nfor\tO\npotentially\tO\nnephrotoxic\tB-Disease\nantibiotics\tO\nand\tO\nthe\tO\noccurrence\tO\nof\tO\nAKI\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nstudy\tO\nwas\tO\ncarried\tO\nout\tO\nas\tO\na\tO\nprospective\tO\n,\tO\nclinical\tO\n,\tO\nnon\tO\n-\tO\ninterventional\tO\n,\tO\nobservational\tO\nstudy\tO\n.\tO\n\nData\tO\ncollection\tO\nwas\tO\nperformed\tO\nover\tO\na\tO\ntotal\tO\nof\tO\n170\tO\ndays\tO\nin\tO\nthree\tO\nICUs\tO\nat\tO\nCharite\tO\n-\tO\nUniversitaetsmedizin\tO\nBerlin\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n675\tO\npatients\tO\nwere\tO\nincluded\tO\n;\tO\n163\tO\nof\tO\nthese\tO\nhad\tO\ntherapy\tO\nwith\tO\nvancomycin\tB-Chemical\n,\tO\ngentamicin\tB-Chemical\n,\tO\nor\tO\ntobramycin\tB-Chemical\n;\tO\nwere\tO\n>\tO\n18\tO\nyears\tO\n;\tO\nand\tO\ntreated\tO\nin\tO\nthe\tO\nICU\tO\nfor\tO\n>\tO\n24\tO\nhours\tO\n.\tO\n\nPatients\tO\nwith\tO\nan\tO\nadherence\tO\nto\tO\nSOP\tO\n>\tO\n70\tO\n%\tO\nwere\tO\nclassified\tO\ninto\tO\nthe\tO\nhigh\tO\nadherence\tO\ngroup\tO\n(\tO\nHAG\tO\n)\tO\nand\tO\npatients\tO\nwith\tO\nan\tO\nadherence\tO\nof\tO\n<\tO\n70\tO\n%\tO\ninto\tO\nthe\tO\nlow\tO\nadherence\tO\ngroup\tO\n(\tO\nLAG\tO\n)\tO\n.\tO\n\nAKI\tB-Disease\nwas\tO\ndefined\tO\naccording\tO\nto\tO\nRIFLE\tO\ncriteria\tO\n.\tO\n\nAdherence\tO\nto\tO\nSOPs\tO\nwas\tO\nevaluated\tO\nby\tO\nretrospective\tO\nexpert\tO\naudit\tO\n.\tO\n\nDevelopment\tO\nof\tO\nAKI\tB-Disease\nwas\tO\ncompared\tO\nbetween\tO\ngroups\tO\nwith\tO\nexact\tO\nChi2\tO\n-\tO\ntest\tO\nand\tO\nmultivariate\tO\nlogistic\tO\nregression\tO\nanalysis\tO\n(\tO\ntwo\tO\n-\tO\nsided\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nLAG\tO\nconsisted\tO\nof\tO\n75\tO\npatients\tO\n(\tO\n46\tO\n%\tO\n)\tO\nversus\tO\n88\tO\nHAG\tO\npatients\tO\n(\tO\n54\tO\n%\tO\n)\tO\n.\tO\n\nAKI\tB-Disease\noccurred\tO\nsignificantly\tO\nmore\tO\noften\tO\nin\tO\nLAG\tO\nwith\tO\n36\tO\n%\tO\nversus\tO\n21\tO\n%\tO\nin\tO\nHAG\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n035\tO\n)\tO\n.\tO\n\nBasic\tO\ncharacteristics\tO\nwere\tO\ncomparable\tO\n,\tO\nexcept\tO\nan\tO\nincreased\tO\nrate\tO\nof\tO\nsoft\tO\ntissue\tO\ninfections\tB-Disease\nin\tO\nLAG\tO\n.\tO\n\nMultivariate\tO\nanalysis\tO\nrevealed\tO\nan\tO\nodds\tO\nratio\tO\nof\tO\n2\tO\n.\tO\n5\tO\n-\tO\nfold\tO\nfor\tO\nLAG\tO\nto\tO\ndevelop\tO\nAKI\tB-Disease\ncompared\tO\nwith\tO\nHAG\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n1\tO\n.\tO\n195\tO\nto\tO\n5\tO\n.\tO\n124\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n039\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nLow\tO\nadherence\tO\nto\tO\nSOPs\tO\nfor\tO\npotentially\tO\nnephrotoxic\tB-Disease\nantibiotics\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nhigher\tO\noccurrence\tO\nof\tO\nAKI\tB-Disease\n.\tO\n\nTRIAL\tO\nREGISTRATION\tO\n:\tO\nCurrent\tO\nControlled\tO\nTrials\tO\nISRCTN54598675\tO\n.\tO\n\nRegistered\tO\n17\tO\nAugust\tO\n2007\tO\n.\tO\n\nRhabdomyolysis\tB-Disease\nin\tO\na\tO\nhepatitis\tB-Disease\nC\tI-Disease\nvirus\tI-Disease\ninfected\tI-Disease\npatient\tO\ntreated\tO\nwith\tO\ntelaprevir\tB-Chemical\nand\tO\nsimvastatin\tB-Chemical\n.\tO\n\nA\tO\n46\tO\n-\tO\nyear\tO\nold\tO\nman\tO\nwith\tO\na\tO\nchronic\tO\nhepatitis\tB-Disease\nC\tI-Disease\nvirus\tI-Disease\ninfection\tI-Disease\nreceived\tO\ntriple\tO\ntherapy\tO\nwith\tO\nribavirin\tB-Chemical\n,\tO\npegylated\tB-Chemical\ninterferon\tI-Chemical\nand\tO\ntelaprevir\tB-Chemical\n.\tO\n\nThe\tO\npatient\tO\nalso\tO\nreceived\tO\nsimvastatin\tB-Chemical\n.\tO\n\nOne\tO\nmonth\tO\nafter\tO\nstarting\tO\nthe\tO\nantiviral\tO\ntherapy\tO\n,\tO\nthe\tO\npatient\tO\nwas\tO\nadmitted\tO\nto\tO\nthe\tO\nhospital\tO\nbecause\tO\nhe\tO\ndeveloped\tO\nrhabdomyolysis\tB-Disease\n.\tO\n\nAt\tO\nadmission\tO\nsimvastatin\tB-Chemical\nand\tO\nall\tO\nantiviral\tO\ndrugs\tO\nwere\tO\ndiscontinued\tO\nbecause\tO\ntoxicity\tB-Disease\ndue\tO\nto\tO\na\tO\ndrug\tO\n-\tO\ndrug\tO\ninteraction\tO\nwas\tO\nsuspected\tO\n.\tO\n\nThe\tO\ncreatine\tB-Chemical\nkinase\tO\npeaked\tO\nat\tO\n62\tO\n,\tO\n246\tO\nIU\tO\n/\tO\nL\tO\nand\tO\nthe\tO\npatient\tO\nwas\tO\ntreated\tO\nwith\tO\nintravenous\tO\nnormal\tO\nsaline\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nrenal\tO\nfunction\tO\nremained\tO\nunaffected\tO\n.\tO\n\nFourteen\tO\ndays\tO\nafter\tO\nhospitalization\tO\n,\tO\ncreatine\tB-Chemical\nkinase\tO\nlevel\tO\nhad\tO\nreturned\tO\nto\tO\n230\tO\nIU\tO\n/\tO\nL\tO\nand\tO\nthe\tO\npatient\tO\nwas\tO\ndischarged\tO\n.\tO\n\nTelaprevir\tB-Chemical\nwas\tO\nconsidered\tO\nthe\tO\nprobable\tO\ncausative\tO\nagent\tO\nof\tO\nan\tO\ninteraction\tO\nwith\tO\nsimvastatin\tB-Chemical\naccording\tO\nto\tO\nthe\tO\nDrug\tO\nInteraction\tO\nProbability\tO\nScale\tO\n.\tO\n\nThe\tO\ninteraction\tO\nis\tO\ndue\tO\nto\tO\ninhibition\tO\nof\tO\nCYP3A4\tO\n-\tO\nmediated\tO\nsimvastatin\tB-Chemical\nclearance\tO\n.\tO\n\nSimvastatin\tB-Chemical\nplasma\tO\nconcentration\tO\nincreased\tO\n30\tO\ntimes\tO\nin\tO\nthis\tO\npatient\tO\nand\tO\nstatin\tB-Chemical\ninduced\tO\nmuscle\tB-Disease\ntoxicity\tI-Disease\nis\tO\nrelated\tO\nto\tO\nthe\tO\nconcentration\tO\nof\tO\nthe\tO\nstatin\tB-Chemical\nin\tO\nblood\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nwith\tO\nthis\tO\ncase\tO\nwe\tO\nillustrate\tO\nthat\tO\ntelaprevir\tB-Chemical\nas\tO\nwell\tO\nas\tO\nstatins\tB-Chemical\nare\tO\nsusceptible\tO\nto\tO\nclinical\tO\nrelevant\tO\ndrug\tO\n-\tO\ndrug\tO\ninteractions\tO\n.\tO\n\nCombination\tO\nof\tO\nbortezomib\tB-Chemical\n,\tO\nthalidomide\tB-Chemical\n,\tO\nand\tO\ndexamethasone\tB-Chemical\n(\tO\nVTD\tO\n)\tO\nas\tO\na\tO\nconsolidation\tO\ntherapy\tO\nafter\tO\nautologous\tO\nstem\tO\ncell\tO\ntransplantation\tO\nfor\tO\nsymptomatic\tO\nmultiple\tB-Disease\nmyeloma\tI-Disease\nin\tO\nJapanese\tO\npatients\tO\n.\tO\n\nConsolidation\tO\ntherapy\tO\nfor\tO\npatients\tO\nwith\tO\nmultiple\tB-Disease\nmyeloma\tI-Disease\n(\tO\nMM\tB-Disease\n)\tO\nhas\tO\nbeen\tO\nwidely\tO\nadopted\tO\nto\tO\nimprove\tO\ntreatment\tO\nresponse\tO\nfollowing\tO\nautologous\tO\nstem\tO\ncell\tO\ntransplantation\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\nretrospectively\tO\nanalyzed\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\ncombination\tO\nregimen\tO\nof\tO\nbortezomib\tB-Chemical\n,\tO\nthalidomide\tB-Chemical\n,\tO\nand\tO\ndexamethasone\tB-Chemical\n(\tO\nVTD\tO\n)\tO\nas\tO\nconsolidation\tO\ntherapy\tO\nin\tO\n24\tO\nJapanese\tO\npatients\tO\nwith\tO\nnewly\tO\ndiagnosed\tO\nMM\tB-Disease\n.\tO\n\nVTD\tO\nconsisted\tO\nof\tO\nbortezomib\tB-Chemical\nat\tO\na\tO\ndose\tO\nof\tO\n1\tO\n.\tO\n3\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nand\tO\ndexamethasone\tB-Chemical\nat\tO\na\tO\ndose\tO\nof\tO\n40\tO\nmg\tO\n/\tO\nday\tO\non\tO\ndays\tO\n1\tO\n,\tO\n8\tO\n,\tO\n15\tO\n,\tO\nand\tO\n22\tO\nof\tO\na\tO\n35\tO\n-\tO\nday\tO\ncycle\tO\n,\tO\nwith\tO\ndaily\tO\noral\tO\nthalidomide\tB-Chemical\nat\tO\na\tO\ndose\tO\nof\tO\n100\tO\nmg\tO\n/\tO\nday\tO\n.\tO\n\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tB-Disease\nand\tO\nthrombocytopenia\tB-Disease\nwere\tO\ndocumented\tO\nin\tO\nfour\tO\nand\tO\nthree\tO\npatients\tO\n(\tO\n17\tO\nand\tO\n13\tO\n%\tO\n)\tO\n,\tO\nrespectively\tO\n,\tO\nbut\tO\ndrug\tO\ndose\tO\nreduction\tO\ndue\tO\nto\tO\ncytopenia\tB-Disease\nwas\tO\nnot\tO\nrequired\tO\nin\tO\nany\tO\ncase\tO\n.\tO\n\nPeripheral\tB-Disease\nneuropathy\tI-Disease\nwas\tO\ncommon\tO\n(\tO\n63\tO\n%\tO\n)\tO\n,\tO\nbut\tO\nsevere\tO\ngrade\tO\n3\tO\n-\tO\n4\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\nwas\tO\nnot\tO\nobserved\tO\n.\tO\n\nVery\tO\ngood\tO\npartial\tO\nresponse\tO\nor\tO\nbetter\tO\nresponse\tO\n(\tO\n>\tO\nVGPR\tO\n)\tO\nrates\tO\nbefore\tO\nand\tO\nafter\tO\nconsolidation\tO\ntherapy\tO\nwere\tO\n54\tO\nand\tO\n79\tO\n%\tO\n,\tO\nrespectively\tO\n.\tO\n\nPatients\tO\nhad\tO\na\tO\nsignificant\tO\nprobability\tO\nof\tO\nimproving\tO\nfrom\tO\n<\tO\nVGPR\tO\nbefore\tO\nconsolidation\tO\ntherapy\tO\nto\tO\n>\tO\nVGPR\tO\nafter\tO\nconsolidation\tO\ntherapy\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n041\tO\n)\tO\n.\tO\n\nThe\tO\nVTD\tO\nregimen\tO\nmay\tO\nbe\tO\nsafe\tO\nand\tO\neffective\tO\nas\tO\na\tO\nconsolidation\tO\ntherapy\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nMM\tO\nin\tO\nJapanese\tO\npopulation\tO\n.\tO\n\nConversion\tO\nto\tO\nsirolimus\tB-Chemical\nameliorates\tO\ncyclosporine\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\nin\tO\nthe\tO\nrat\tO\n:\tO\nfocus\tO\non\tO\nserum\tO\n,\tO\nurine\tO\n,\tO\ngene\tO\n,\tO\nand\tO\nprotein\tO\nrenal\tO\nexpression\tO\nbiomarkers\tO\n.\tO\n\nProtocols\tO\nof\tO\nconversion\tO\nfrom\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\n(\tO\nCsA\tB-Chemical\n)\tO\nto\tO\nsirolimus\tB-Chemical\n(\tO\nSRL\tB-Chemical\n)\tO\nhave\tO\nbeen\tO\nwidely\tO\nused\tO\nin\tO\nimmunotherapy\tO\nafter\tO\ntransplantation\tO\nto\tO\nprevent\tO\nCsA\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n,\tO\nbut\tO\nthe\tO\nmolecular\tO\nmechanisms\tO\nunderlying\tO\nthese\tO\nprotocols\tO\nremain\tO\nnuclear\tO\n.\tO\n\nThis\tO\nstudy\tO\naimed\tO\nto\tO\nidentify\tO\nthe\tO\nmolecular\tO\npathways\tO\nand\tO\nputative\tO\nbiomarkers\tO\nof\tO\nCsA\tB-Chemical\n-\tO\nto\tO\n-\tO\nSRL\tB-Chemical\nconversion\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\n.\tO\n\nFour\tO\nanimal\tO\ngroups\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nwere\tO\ntested\tO\nduring\tO\n9\tO\nweeks\tO\n:\tO\ncontrol\tO\n,\tO\nCsA\tB-Chemical\n,\tO\nSRL\tB-Chemical\n,\tO\nand\tO\nconversion\tO\n(\tO\nCsA\tB-Chemical\nfor\tO\n3\tO\nweeks\tO\nfollowed\tO\nby\tO\nSRL\tB-Chemical\nfor\tO\n6\tO\nweeks\tO\n)\tO\n.\tO\n\nClassical\tO\nand\tO\nemergent\tO\nserum\tO\n,\tO\nurinary\tO\n,\tO\nand\tO\nkidney\tO\ntissue\tO\n(\tO\ngene\tO\nand\tO\nprotein\tO\nexpression\tO\n)\tO\nmarkers\tO\nwere\tO\nassessed\tO\n.\tO\n\nRenal\tB-Disease\nlesions\tI-Disease\nwere\tO\nanalyzed\tO\nin\tO\nhematoxylin\tB-Chemical\nand\tO\neosin\tB-Chemical\n,\tO\nperiodic\tO\nacid\tO\n-\tO\nSchiff\tO\n,\tO\nand\tO\nMasson\tO\n'\tO\ns\tO\ntrichrome\tO\nstains\tO\n.\tO\n\nSRL\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\npresented\tO\nproteinuria\tB-Disease\nand\tO\nNGAL\tO\n(\tO\nserum\tO\nand\tO\nurinary\tO\n)\tO\nas\tO\nthe\tO\nbest\tO\nmarkers\tO\nof\tO\nrenal\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nShort\tO\nCsA\tB-Chemical\ntreatment\tO\npresented\tO\nslight\tO\nor\tO\neven\tO\nabsent\tO\nkidney\tB-Disease\nlesions\tI-Disease\nand\tO\nTGF\tO\n-\tO\nb\tO\n,\tO\nNF\tO\n-\tO\nkb\tO\n,\tO\nmTOR\tO\n,\tO\nPCNA\tO\n,\tO\nTP53\tO\n,\tO\nKIM\tO\n-\tO\n1\tO\n,\tO\nand\tO\nCTGF\tO\nas\tO\nrelevant\tO\ngene\tO\nand\tO\nprotein\tO\nchanges\tO\n.\tO\n\nProlonged\tO\nCsA\tB-Chemical\nexposure\tO\naggravated\tO\nrenal\tB-Disease\ndamage\tI-Disease\n,\tO\nwithout\tO\nclear\tO\nchanges\tO\non\tO\nthe\tO\ntraditional\tO\nmarkers\tO\n,\tO\nbut\tO\nwith\tO\nchanges\tO\nin\tO\nserums\tO\nTGF\tO\n-\tO\nb\tO\nand\tO\nIL\tO\n-\tO\n7\tO\n,\tO\nTBARs\tO\nclearance\tO\n,\tO\nand\tO\nkidney\tO\nTGF\tO\n-\tO\nb\tO\nand\tO\nmTOR\tO\n.\tO\n\nConversion\tO\nto\tO\nSRL\tB-Chemical\nprevented\tO\nCsA\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ndamage\tI-Disease\nevolution\tO\n(\tO\nabsent\tO\n/\tO\nmild\tO\ngrade\tO\nlesions\tO\n)\tO\n,\tO\nwhile\tO\nNGAL\tO\n(\tO\nserum\tO\nversus\tO\nurine\tO\n)\tO\nseems\tO\nto\tO\nbe\tO\na\tO\nfeasible\tO\nbiomarker\tO\nof\tO\nCsA\tB-Chemical\nreplacement\tO\nto\tO\nSRL\tB-Chemical\n.\tO\n\nKinin\tO\nB2\tO\nreceptor\tO\ndeletion\tO\nand\tO\nblockage\tO\nameliorates\tO\ncisplatin\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nrenal\tI-Disease\ninjury\tI-Disease\n.\tO\n\nCisplatin\tB-Chemical\ntreatment\tO\nhas\tO\nbeen\tO\nadopted\tO\nin\tO\nsome\tO\nchemotherapies\tO\n;\tO\nhowever\tO\n,\tO\nthis\tO\ndrug\tO\ncan\tO\ninduce\tO\nacute\tB-Disease\nkidney\tI-Disease\ninjury\tI-Disease\ndue\tO\nits\tO\nability\tO\nto\tO\nnegatively\tO\naffect\tO\nrenal\tO\nfunction\tO\n,\tO\naugment\tO\nserum\tO\nlevels\tO\nof\tO\ncreatinine\tB-Chemical\nand\tO\nurea\tB-Chemical\n,\tO\nincrease\tO\nthe\tO\nacute\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\nscore\tO\nand\tO\nup\tO\n-\tO\nregulate\tO\ncytokines\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nIL\tO\n-\tO\n1b\tO\nand\tO\nTNF\tO\n-\tO\na\tO\n)\tO\n.\tO\n\nThe\tO\nkinin\tO\nB2\tO\nreceptor\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nthe\tO\ninflammation\tB-Disease\nprocess\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\nregulation\tO\nof\tO\ncytokine\tO\nexpression\tO\n,\tO\nand\tO\nits\tO\ndeletion\tO\nresulted\tO\nin\tO\nan\tO\nimprovement\tO\nin\tO\nthe\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\nstatus\tO\n.\tO\n\nTo\tO\nexamine\tO\nthe\tO\nrole\tO\nof\tO\nthe\tO\nkinin\tO\nB2\tO\nreceptor\tO\nin\tO\ncisplatin\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nkidney\tI-Disease\ninjury\tI-Disease\n,\tO\nkinin\tO\nB2\tO\nreceptor\tO\nknockout\tO\nmice\tO\nwere\tO\nchallenged\tO\nwith\tO\ncisplatin\tB-Chemical\n.\tO\n\nAdditionally\tO\n,\tO\nWT\tO\nmice\tO\nwere\tO\ntreated\tO\nwith\tO\na\tO\nB2\tO\nreceptor\tO\nantagonist\tO\nafter\tO\ncisplatin\tB-Chemical\nadministration\tO\n.\tO\n\nB2\tO\nreceptor\tO\n-\tO\ndeficient\tO\nmice\tO\nwere\tO\nless\tO\nsensitive\tO\nto\tO\nthis\tO\ndrug\tO\nthan\tO\nthe\tO\nWT\tO\nmice\tO\n,\tO\nas\tO\nshown\tO\nby\tO\nreduced\tO\nweight\tB-Disease\nloss\tI-Disease\n,\tO\nbetter\tO\npreservation\tO\nof\tO\nkidney\tO\nfunction\tO\n,\tO\ndown\tO\nregulation\tO\nof\tO\ninflammatory\tO\ncytokines\tO\nand\tO\nless\tO\nacute\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nMoreover\tO\n,\tO\ntreatment\tO\nwith\tO\nthe\tO\nkinin\tO\nB2\tO\nreceptor\tO\nantagonist\tO\neffectively\tO\nreduced\tO\nthe\tO\nlevels\tO\nof\tO\nserum\tO\ncreatinine\tB-Chemical\nand\tO\nblood\tO\nurea\tB-Chemical\nafter\tO\ncisplatin\tB-Chemical\nadministration\tO\n.\tO\n\nThus\tO\n,\tO\nour\tO\ndata\tO\nsuggest\tO\nthat\tO\nthe\tO\nkinin\tO\nB2\tO\nreceptor\tO\nis\tO\ninvolved\tO\nin\tO\ncisplatin\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nkidney\tI-Disease\ninjury\tI-Disease\nby\tO\nmediating\tO\nthe\tO\nnecrotic\tB-Disease\nprocess\tO\nand\tO\nthe\tO\nexpression\tO\nof\tO\ninflammatory\tO\ncytokines\tO\n,\tO\nthus\tO\nresulting\tO\nin\tO\ndeclined\tO\nrenal\tO\nfunction\tO\n.\tO\n\nThese\tO\nresults\tO\nhighlight\tO\nthe\tO\nkinin\tO\nB2\tO\nreceptor\tO\nantagonist\tO\ntreatment\tO\nin\tO\namelioration\tO\nof\tO\nnephrotoxicity\tB-Disease\ninduced\tO\nby\tO\ncisplatin\tB-Chemical\ntherapy\tO\n.\tO\n\nSafety\tO\nand\tO\nefficacy\tO\nof\tO\nfluocinolone\tB-Chemical\nacetonide\tI-Chemical\nintravitreal\tO\nimplant\tO\n(\tO\n0\tO\n.\tO\n59\tO\nmg\tO\n)\tO\nin\tO\nbirdshot\tB-Disease\nretinochoroidopathy\tI-Disease\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nreport\tO\nthe\tO\ntreatment\tO\noutcomes\tO\nof\tO\nthe\tO\nfluocinolone\tB-Chemical\nacetonide\tI-Chemical\nintravitreal\tO\nimplant\tO\n(\tO\n0\tO\n.\tO\n59\tO\nmg\tO\n)\tO\nin\tO\npatients\tO\nwith\tO\nbirdshot\tB-Disease\nretinochoroidopathy\tI-Disease\nwhose\tO\ndisease\tO\nis\tO\nrefractory\tO\nor\tO\nintolerant\tO\nto\tO\nconventional\tO\nimmunomodulatory\tO\ntherapy\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nretrospective\tO\ncase\tO\nseries\tO\ninvolving\tO\n11\tO\nbirdshot\tB-Disease\nretinochoroidopathy\tI-Disease\npatients\tO\n(\tO\n11\tO\neyes\tO\n)\tO\n.\tO\n\nEleven\tO\npatients\tO\n(\tO\n11\tO\neyes\tO\n)\tO\nunderwent\tO\nsurgery\tO\nfor\tO\nfluocinolone\tB-Chemical\nacetonide\tI-Chemical\nimplant\tO\n(\tO\n0\tO\n.\tO\n59\tO\nmg\tO\n)\tO\n.\tO\n\nTreatment\tO\noutcomes\tO\nof\tO\ninterest\tO\nwere\tO\nnoted\tO\nat\tO\nbaseline\tO\n,\tO\nbefore\tO\nfluocinolone\tB-Chemical\nacetonide\tI-Chemical\nimplant\tO\n,\tO\nand\tO\nthen\tO\nat\tO\n6\tO\nmonths\tO\n,\tO\n1\tO\nyear\tO\n,\tO\n2\tO\nyears\tO\n,\tO\n3\tO\nyears\tO\n,\tO\nand\tO\nbeyond\tO\n3\tO\nyears\tO\n.\tO\n\nDisease\tO\nactivity\tO\nmarkers\tO\n,\tO\nincluding\tO\nsigns\tO\nof\tO\nocular\tO\ninflammation\tB-Disease\n,\tO\nevidence\tO\nof\tO\nretinal\tB-Disease\nvasculitis\tI-Disease\n,\tO\nSwedish\tO\ninteractive\tO\nthreshold\tO\nalgorithm\tO\n-\tO\nshort\tO\nwavelength\tO\nautomated\tO\nperimetry\tO\nHumphrey\tO\nvisual\tO\nfield\tO\nanalysis\tO\n,\tO\nelectroretinographic\tO\nparameters\tO\n,\tO\nand\tO\noptical\tO\ncoherence\tO\ntomography\tO\nwere\tO\nrecorded\tO\n.\tO\n\nData\tO\non\tO\noccurrence\tO\nof\tO\ncataract\tB-Disease\nand\tO\nraised\tB-Disease\nintraocular\tI-Disease\npressure\tI-Disease\nwere\tO\ncollected\tO\nin\tO\nall\tO\neyes\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIntraocular\tO\ninflammation\tB-Disease\nwas\tO\npresent\tO\nin\tO\n54\tO\n.\tO\n5\tO\n,\tO\n9\tO\n.\tO\n9\tO\n,\tO\n11\tO\n.\tO\n1\tO\n,\tO\nand\tO\n0\tO\n%\tO\nof\tO\npatients\tO\nat\tO\nbaseline\tO\n,\tO\n6\tO\nmonths\tO\n,\tO\n1\tO\nyear\tO\n,\tO\n2\tO\nyears\tO\n,\tO\n3\tO\nyears\tO\n,\tO\nand\tO\nbeyond\tO\n3\tO\nyears\tO\nafter\tO\nreceiving\tO\nthe\tO\nimplant\tO\n,\tO\nrespectively\tO\n.\tO\n\nActive\tO\nvasculitis\tB-Disease\nwas\tO\nnoted\tO\nin\tO\n36\tO\n.\tO\n3\tO\n%\tO\npatients\tO\nat\tO\nbaseline\tO\nand\tO\n0\tO\n%\tO\nat\tO\n3\tO\nyears\tO\nof\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nMore\tO\nthan\tO\n20\tO\n%\tO\n(\tO\n47\tO\n.\tO\n61\tO\n-\tO\n67\tO\n.\tO\n2\tO\n%\tO\n)\tO\nreduction\tO\nin\tO\ncentral\tO\nretinal\tO\nthickness\tO\nwas\tO\nnoted\tO\nin\tO\nall\tO\npatients\tO\nwith\tO\ncystoid\tB-Disease\nmacular\tI-Disease\nedema\tI-Disease\nat\tO\n6\tO\nmonths\tO\n,\tO\n1\tO\nyear\tO\n,\tO\n2\tO\nyears\tO\n,\tO\nand\tO\n3\tO\nyears\tO\npostimplant\tO\n.\tO\n\nAt\tO\nbaseline\tO\n,\tO\n54\tO\n.\tO\n5\tO\n%\tO\npatients\tO\nwere\tO\non\tO\nimmunomodulatory\tO\nagents\tO\n.\tO\n\nThis\tO\npercentage\tO\ndecreased\tO\nto\tO\n45\tO\n.\tO\n45\tO\n,\tO\n44\tO\n.\tO\n4\tO\n,\tO\nand\tO\n14\tO\n.\tO\n28\tO\n%\tO\nat\tO\n1\tO\nyear\tO\n,\tO\n2\tO\nyears\tO\n,\tO\nand\tO\n3\tO\nyears\tO\npostimplant\tO\n,\tO\nrespectively\tO\n.\tO\n\nAdverse\tO\nevents\tO\nincluded\tO\nincreased\tB-Disease\nintraocular\tI-Disease\npressure\tI-Disease\n(\tO\n54\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\ncataract\tB-Disease\nformation\tO\n(\tO\n100\tO\n%\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\ndata\tO\nsuggest\tO\nthat\tO\nfluocinolone\tB-Chemical\nacetonide\tI-Chemical\nimplant\tO\n(\tO\n0\tO\n.\tO\n59\tO\nmg\tO\n)\tO\nhelps\tO\nto\tO\ncontrol\tO\ninflammation\tB-Disease\nin\tO\notherwise\tO\ntreatment\tO\n-\tO\nrefractory\tO\ncases\tO\nof\tO\nbirdshot\tB-Disease\nretinochoroidopathy\tI-Disease\n.\tO\n\nIt\tO\nis\tO\nassociated\tO\nwith\tO\nsignificant\tO\nside\tO\neffects\tO\nof\tO\ncataract\tB-Disease\nand\tO\nocular\tB-Disease\nhypertension\tI-Disease\nrequiring\tO\ntreatment\tO\n.\tO\n\nOptimal\tO\nprecurarizing\tO\ndose\tO\nof\tO\nrocuronium\tB-Chemical\nto\tO\ndecrease\tO\nfasciculation\tB-Disease\nand\tO\nmyalgia\tB-Disease\nfollowing\tO\nsuccinylcholine\tB-Chemical\nadministration\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nSuccinylcholine\tB-Chemical\ncommonly\tO\nproduces\tO\nfrequent\tO\nadverse\tO\neffects\tO\n,\tO\nincluding\tO\nmuscle\tB-Disease\nfasciculation\tI-Disease\nand\tO\nmyalgia\tB-Disease\n.\tO\n\nThe\tO\ncurrent\tO\nstudy\tO\nidentified\tO\nthe\tO\noptimal\tO\ndose\tO\nof\tO\nrocuronium\tB-Chemical\nto\tO\nprevent\tO\nsuccinylcholine\tB-Chemical\n-\tO\ninduced\tO\nfasciculation\tB-Disease\nand\tO\nmyalgia\tB-Disease\nand\tO\nevaluated\tO\nthe\tO\ninfluence\tO\nof\tO\nrocuronium\tB-Chemical\non\tO\nthe\tO\nspeed\tO\nof\tO\nonset\tO\nproduced\tO\nby\tO\nsuccinylcholine\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblinded\tO\nstudy\tO\nwas\tO\nconducted\tO\nin\tO\n100\tO\npatients\tO\nrandomly\tO\nallocated\tO\ninto\tO\nfive\tO\ngroups\tO\nof\tO\n20\tO\npatients\tO\neach\tO\n.\tO\n\nPatients\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\n0\tO\n.\tO\n02\tO\n,\tO\n0\tO\n.\tO\n03\tO\n,\tO\n0\tO\n.\tO\n04\tO\n,\tO\n0\tO\n.\tO\n05\tO\nand\tO\n0\tO\n.\tO\n06\tO\nmg\tO\n/\tO\nkg\tO\nrocuronium\tB-Chemical\nas\tO\na\tO\nprecurarizing\tO\ndose\tO\n.\tO\n\nNeuromuscular\tO\nmonitoring\tO\nafter\tO\neach\tO\nprecurarizing\tO\ndose\tO\nwas\tO\nrecorded\tO\nfrom\tO\nthe\tO\nadductor\tO\npollicis\tO\nmuscle\tO\nusing\tO\nacceleromyography\tO\nwith\tO\ntrain\tO\n-\tO\nof\tO\n-\tO\nfour\tO\nstimulation\tO\nof\tO\nthe\tO\nulnar\tO\nnerve\tO\n.\tO\n\nAll\tO\npatients\tO\nreceived\tO\nsuccinylcholine\tB-Chemical\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nat\tO\n2\tO\nminutes\tO\nafter\tO\nthe\tO\nprecurarization\tO\n,\tO\nand\tO\nwere\tO\nassessed\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nfasciculations\tB-Disease\n,\tO\nwhile\tO\nmyalgia\tB-Disease\nwas\tO\nassessed\tO\nat\tO\n24\tO\nhours\tO\nafter\tO\nsurgery\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nvisible\tO\nmuscle\tB-Disease\nfasciculation\tI-Disease\nwas\tO\nsignificantly\tO\nless\tO\nwith\tO\nincreasing\tO\nthe\tO\namount\tO\nof\tO\nprecurarizing\tO\ndose\tO\nof\tO\nrocuronium\tB-Chemical\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThose\tO\nof\tO\nmyalgia\tB-Disease\ntend\tO\nto\tO\ndecrease\tO\naccording\tO\nto\tO\nincreasing\tO\nthe\tO\namount\tO\nof\tO\nprecurarizing\tO\ndose\tO\nof\tO\nrocuronium\tB-Chemical\n,\tO\nbut\tO\nthere\tO\nwas\tO\nno\tO\nsignificance\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n072\tO\n)\tO\n.\tO\n\nThe\tO\nonset\tO\ntime\tO\nof\tO\nsuccinylcholine\tB-Chemical\nwas\tO\nsignificantly\tO\nlonger\tO\nwith\tO\nincreasing\tO\nthe\tO\namount\tO\nof\tO\nprecurarizing\tO\ndose\tO\nof\tO\nrocuronium\tB-Chemical\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPrecurarization\tO\nwith\tO\n0\tO\n.\tO\n04\tO\nmg\tO\n/\tO\nkg\tO\nrocuronium\tB-Chemical\nwas\tO\nthe\tO\noptimal\tO\ndose\tO\nconsidering\tO\nthe\tO\nreduction\tO\nin\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nfasciculation\tB-Disease\nand\tO\nmyalgia\tB-Disease\nwith\tO\nacceptable\tO\nonset\tO\ntime\tO\n,\tO\nand\tO\nthe\tO\nsafe\tO\nand\tO\neffective\tO\nprecurarization\tO\n.\tO\n\nAbsence\tO\nof\tO\nPKC\tO\n-\tO\nalpha\tO\nattenuates\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\n.\tO\n\nLithium\tB-Chemical\n,\tO\nan\tO\neffective\tO\nantipsychotic\tO\n,\tO\ninduces\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\n(\tO\nNDI\tB-Disease\n)\tO\nin\tO\n40\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nThe\tO\ndecreased\tO\ncapacity\tO\nto\tO\nconcentrate\tO\nurine\tO\nis\tO\nlikely\tO\ndue\tO\nto\tO\nlithium\tB-Chemical\nacutely\tO\ndisrupting\tO\nthe\tO\ncAMP\tB-Chemical\npathway\tO\nand\tO\nchronically\tO\nreducing\tO\nurea\tB-Chemical\ntransporter\tO\n(\tO\nUT\tO\n-\tO\nA1\tO\n)\tO\nand\tO\nwater\tO\nchannel\tO\n(\tO\nAQP2\tO\n)\tO\nexpression\tO\nin\tO\nthe\tO\ninner\tO\nmedulla\tO\n.\tO\n\nTargeting\tO\nan\tO\nalternative\tO\nsignaling\tO\npathway\tO\n,\tO\nsuch\tO\nas\tO\nPKC\tO\n-\tO\nmediated\tO\nsignaling\tO\n,\tO\nmay\tO\nbe\tO\nan\tO\neffective\tO\nmethod\tO\nof\tO\ntreating\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\npolyuria\tB-Disease\n.\tO\n\nPKC\tO\n-\tO\nalpha\tO\nnull\tO\nmice\tO\n(\tO\nPKCa\tO\nKO\tO\n)\tO\nand\tO\nstrain\tO\n-\tO\nmatched\tO\nwild\tO\ntype\tO\n(\tO\nWT\tO\n)\tO\ncontrols\tO\nwere\tO\ntreated\tO\nwith\tO\nlithium\tB-Chemical\nfor\tO\n0\tO\n,\tO\n3\tO\nor\tO\n5\tO\ndays\tO\n.\tO\n\nWT\tO\nmice\tO\nhad\tO\nincreased\tO\nurine\tO\noutput\tO\nand\tO\nlowered\tO\nurine\tO\nosmolality\tO\nafter\tO\n3\tO\nand\tO\n5\tO\ndays\tO\nof\tO\ntreatment\tO\nwhereas\tO\nPKCa\tO\nKO\tO\nmice\tO\nhad\tO\nno\tO\nchange\tO\nin\tO\nurine\tO\noutput\tO\nor\tO\nconcentration\tO\n.\tO\n\nWestern\tO\nblot\tO\nanalysis\tO\nrevealed\tO\nthat\tO\nAQP2\tO\nexpression\tO\nin\tO\nmedullary\tO\ntissues\tO\nwas\tO\nlowered\tO\nafter\tO\n3\tO\nand\tO\n5\tO\ndays\tO\nin\tO\nWT\tO\nmice\tO\n;\tO\nhowever\tO\n,\tO\nAQP2\tO\nwas\tO\nunchanged\tO\nin\tO\nPKCa\tO\nKO\tO\n.\tO\n\nSimilar\tO\nresults\tO\nwere\tO\nobserved\tO\nwith\tO\nUT\tO\n-\tO\nA1\tO\nexpression\tO\n.\tO\n\nAnimals\tO\nwere\tO\nalso\tO\ntreated\tO\nwith\tO\nlithium\tB-Chemical\nfor\tO\n6\tO\nweeks\tO\n.\tO\n\nLithium\tB-Chemical\n-\tO\ntreated\tO\nWT\tO\nmice\tO\nhad\tO\n19\tO\n-\tO\nfold\tO\nincreased\tO\nurine\tO\noutput\tO\nwhereas\tO\ntreated\tO\nPKCa\tO\nKO\tO\nanimals\tO\nhad\tO\na\tO\n4\tO\n-\tO\nfold\tO\nincrease\tO\nin\tO\noutput\tO\n.\tO\n\nAQP2\tO\nand\tO\nUT\tO\n-\tO\nA1\tO\nexpression\tO\nwas\tO\nlowered\tO\nin\tO\n6\tO\nweek\tO\nlithium\tB-Chemical\n-\tO\ntreated\tO\nWT\tO\nanimals\tO\nwhereas\tO\nin\tO\ntreated\tO\nPKCa\tO\nKO\tO\nmice\tO\n,\tO\nAQP2\tO\nwas\tO\nonly\tO\nreduced\tO\nby\tO\n2\tO\n-\tO\nfold\tO\nand\tO\nUT\tO\n-\tO\nA1\tO\nexpression\tO\nwas\tO\nunaffected\tO\n.\tO\n\nUrinary\tO\nsodium\tB-Chemical\n,\tO\npotassium\tB-Chemical\nand\tO\ncalcium\tB-Chemical\nwere\tO\nelevated\tO\nin\tO\nlithium\tB-Chemical\n-\tO\nfed\tO\nWT\tO\nbut\tO\nnot\tO\nin\tO\nlithium\tB-Chemical\n-\tO\nfed\tO\nPKCa\tO\nKO\tO\nmice\tO\n.\tO\n\nOur\tO\ndata\tO\nshow\tO\nthat\tO\nablation\tO\nof\tO\nPKCa\tO\npreserves\tO\nAQP2\tO\nand\tO\nUT\tO\n-\tO\nA1\tO\nprotein\tO\nexpression\tO\nand\tO\nlocalization\tO\nin\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\nNDI\tB-Disease\n,\tO\nand\tO\nprevents\tO\nthe\tO\ndevelopment\tO\nof\tO\nthe\tO\nsevere\tO\npolyuria\tB-Disease\nassociated\tO\nwith\tO\nlithium\tB-Chemical\ntherapy\tO\n.\tO\n\nIs\tO\nDysguesia\tB-Disease\nGoing\tO\nto\tO\nbe\tO\na\tO\nRare\tO\nor\tO\na\tO\nCommon\tO\nSide\tO\n-\tO\neffect\tO\nof\tO\nAmlodipine\tB-Chemical\n?\tO\n\nA\tO\nvery\tO\nrare\tO\nside\tO\n-\tO\neffect\tO\nof\tO\namlodipine\tB-Chemical\nis\tO\ndysguesia\tB-Disease\n.\tO\n\nA\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\nproduced\tO\nonly\tO\none\tO\ncase\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nabout\tO\na\tO\nfemale\tO\nwith\tO\nessential\tO\nhypertension\tB-Disease\non\tO\ndrug\tO\ntreatment\tO\nwith\tO\namlodipine\tB-Chemical\ndeveloped\tO\nloss\tB-Disease\nof\tI-Disease\ntaste\tI-Disease\nsensation\tI-Disease\n.\tO\n\nCondition\tO\nmoderately\tO\nimproved\tO\non\tO\nstoppage\tO\nof\tO\nthe\tO\ndrug\tO\nfor\tO\n25\tO\ndays\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\namlodipine\tB-Chemical\ncan\tO\ncause\tO\ndysguesia\tB-Disease\n.\tO\n\nHere\tO\n,\tO\nwe\tO\ndescribe\tO\nthe\tO\nclinical\tO\npresentation\tO\nand\tO\nreview\tO\nthe\tO\nrelevant\tO\nliterature\tO\non\tO\namlodipine\tB-Chemical\nand\tO\ndysguesia\tB-Disease\n.\tO\n\nRhabdomyolysis\tB-Disease\nin\tO\nassociation\tO\nwith\tO\nsimvastatin\tB-Chemical\nand\tO\ndosage\tO\nincrement\tO\nin\tO\nclarithromycin\tB-Chemical\n.\tO\n\nClarithromycin\tB-Chemical\nis\tO\nthe\tO\nmost\tO\ndocumented\tO\ncytochrome\tO\nP450\tO\n3A4\tO\n(\tO\nCYP3A4\tO\n)\tO\ninhibitor\tO\nto\tO\ncause\tO\nan\tO\nadverse\tO\ninteraction\tO\nwith\tO\nsimvastatin\tB-Chemical\n.\tO\n\nThis\tO\nparticular\tO\ncase\tO\nis\tO\nof\tO\ninterest\tO\nas\tO\nrhabdomyolysis\tB-Disease\nonly\tO\noccurred\tO\nafter\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\ndose\tO\nof\tO\nclarithromycin\tB-Chemical\n.\tO\n\nThe\tO\npatient\tO\ndeveloped\tO\nraised\tO\ncardiac\tO\nbiomarkers\tO\nwithout\tO\nany\tO\nobvious\tO\ncardiac\tO\nissues\tO\n,\tO\na\tO\nphenomenon\tO\nthat\tO\nhas\tO\nbeen\tO\nlinked\tO\nto\tO\nrhabdomyolysis\tB-Disease\npreviously\tO\n.\tO\n\nTo\tO\ndate\tO\n,\tO\nthere\tO\nhas\tO\nbeen\tO\nno\tO\nreported\tO\neffect\tO\nof\tO\nrhabdomyolysis\tB-Disease\non\tO\nthe\tO\nstructure\tO\nand\tO\nfunction\tO\nof\tO\ncardiac\tO\nmuscle\tO\n.\tO\n\nClinicians\tO\nneed\tO\nto\tO\nbe\tO\naware\tO\nof\tO\nprescribing\tO\nconcomitant\tO\nmedications\tO\nthat\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nmyopathy\tB-Disease\nor\tO\ninhibit\tO\nthe\tO\nCYP3A4\tO\nenzyme\tO\n.\tO\n\nOur\tO\ncase\tO\nsuggests\tO\nthat\tO\ntroponin\tO\nelevation\tO\ncould\tO\nbe\tO\nassociated\tO\nwith\tO\nstatin\tB-Chemical\ninduced\tO\nrhabdomyolysis\tB-Disease\n,\tO\nwhich\tO\nmay\tO\nwarrant\tO\nfurther\tO\nstudies\tO\n.\tO\n\nCharacterization\tO\nof\tO\na\tO\nnovel\tO\nBCHE\tO\n\"\tO\nsilent\tO\n\"\tO\nallele\tO\n:\tO\npoint\tO\nmutation\tO\n(\tO\np\tO\n.\tO\nVal204Asp\tO\n)\tO\ncauses\tO\nloss\tO\nof\tO\nactivity\tO\nand\tO\nprolonged\tO\napnea\tB-Disease\nwith\tO\nsuxamethonium\tB-Chemical\n.\tO\n\nButyrylcholinesterase\tB-Disease\ndeficiency\tI-Disease\nis\tO\ncharacterized\tO\nby\tO\nprolonged\tO\napnea\tB-Disease\nafter\tO\nthe\tO\nuse\tO\nof\tO\nmuscle\tO\nrelaxants\tO\n(\tO\nsuxamethonium\tB-Chemical\nor\tO\nmivacurium\tB-Chemical\n)\tO\nin\tO\npatients\tO\nwho\tO\nhave\tO\nmutations\tO\nin\tO\nthe\tO\nBCHE\tO\ngene\tO\n.\tO\n\nHere\tO\n,\tO\nwe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nprolonged\tO\nneuromuscular\tO\nblock\tO\nafter\tO\nadministration\tO\nof\tO\nsuxamethonium\tB-Chemical\nleading\tO\nto\tO\nthe\tO\ndiscovery\tO\nof\tO\na\tO\nnovel\tO\nBCHE\tO\nvariant\tO\n(\tO\nc\tO\n.\tO\n695T\tO\n>\tO\nA\tO\n,\tO\np\tO\n.\tO\nVal204Asp\tO\n)\tO\n.\tO\n\nInhibition\tO\nstudies\tO\n,\tO\nkinetic\tO\nanalysis\tO\nand\tO\nmolecular\tO\ndynamics\tO\nwere\tO\nundertaken\tO\nto\tO\nunderstand\tO\nhow\tO\nthis\tO\nmutation\tO\ndisrupts\tO\nthe\tO\ncatalytic\tO\ntriad\tO\nand\tO\ndetermines\tO\na\tO\n\"\tO\nsilent\tO\n\"\tO\nphenotype\tO\n.\tO\n\nLow\tO\nactivity\tO\nof\tO\npatient\tO\nplasma\tO\nbutyrylcholinesterase\tO\nwith\tO\nbutyrylthiocholine\tB-Chemical\n(\tO\nBTC\tB-Chemical\n)\tO\nand\tO\nbenzoylcholine\tB-Chemical\n,\tO\nand\tO\nvalues\tO\nof\tO\ndibucaine\tB-Chemical\nand\tO\nfluoride\tB-Chemical\nnumbers\tO\nfit\tO\nwith\tO\nheterozygous\tO\natypical\tO\nsilent\tO\ngenotype\tO\n.\tO\n\nElectrophoretic\tO\nanalysis\tO\nof\tO\nplasma\tO\nBChE\tO\nof\tO\nthe\tO\nproband\tO\nand\tO\nhis\tO\nmother\tO\nshowed\tO\nthat\tO\npatient\tO\nhas\tO\na\tO\nreduced\tO\namount\tO\nof\tO\ntetrameric\tO\nenzyme\tO\nin\tO\nplasma\tO\nand\tO\nthat\tO\nminor\tO\nfast\tO\n-\tO\nmoving\tO\nBChE\tO\ncomponents\tO\n:\tO\nmonomer\tO\n,\tO\ndimer\tO\n,\tO\nand\tO\nmonomer\tO\n-\tO\nalbumin\tO\nconjugate\tO\nare\tO\nmissing\tO\n.\tO\n\nKinetic\tO\nanalysis\tO\nshowed\tO\nthat\tO\nthe\tO\np\tO\n.\tO\nVal204Asp\tO\n/\tO\np\tO\n.\tO\nAsp70Gly\tO\n-\tO\np\tO\n.\tO\nAla539Thr\tO\nBChE\tO\ndisplays\tO\na\tO\npure\tO\nMichaelian\tO\nbehavior\tO\nwith\tO\nBTC\tB-Chemical\nas\tO\nthe\tO\nsubstrate\tO\n.\tO\n\nBoth\tO\ncatalytic\tO\nparameters\tO\nKm\tO\n=\tO\n265\tO\nuM\tO\nfor\tO\nBTC\tB-Chemical\n,\tO\ntwo\tO\ntimes\tO\nhigher\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\natypical\tO\nenzyme\tO\n,\tO\nand\tO\na\tO\nlow\tO\nVmax\tO\nare\tO\nconsistent\tO\nwith\tO\nthe\tO\nabsence\tO\nof\tO\nactivity\tO\nagainst\tO\nsuxamethonium\tB-Chemical\n.\tO\n\nMolecular\tO\ndynamic\tO\n(\tO\nMD\tO\n)\tO\nsimulations\tO\nshowed\tO\nthat\tO\nthe\tO\noverall\tO\neffect\tO\nof\tO\nthe\tO\nmutation\tO\np\tO\n.\tO\nVal204Asp\tO\nis\tO\ndisruption\tO\nof\tO\nhydrogen\tB-Chemical\nbonding\tO\nbetween\tO\nGln223\tO\nand\tO\nGlu441\tO\n,\tO\nleading\tO\nSer198\tO\nand\tO\nHis438\tO\nto\tO\nmove\tO\naway\tO\nfrom\tO\neach\tO\nother\tO\nwith\tO\nsubsequent\tO\ndisruption\tO\nof\tO\nthe\tO\ncatalytic\tO\ntriad\tO\nfunctionality\tO\nregardless\tO\nof\tO\nthe\tO\ntype\tO\nof\tO\nsubstrate\tO\n.\tO\n\nMD\tO\nalso\tO\nshowed\tO\nthat\tO\nthe\tO\nenzyme\tO\nvolume\tO\nis\tO\nincreased\tO\n,\tO\nsuggesting\tO\na\tO\npre\tO\n-\tO\ndenaturation\tO\nstate\tO\n.\tO\n\nThis\tO\nfits\tO\nwith\tO\nthe\tO\nreduced\tO\nconcentration\tO\nof\tO\np\tO\n.\tO\nAla204Asp\tO\n/\tO\np\tO\n.\tO\nAsp70Gly\tO\n-\tO\np\tO\n.\tO\nAla539Thr\tO\ntetrameric\tO\nenzyme\tO\nin\tO\nthe\tO\nplasma\tO\nand\tO\nnon\tO\n-\tO\ndetectable\tO\nfast\tO\nmoving\tO\n-\tO\nbands\tO\non\tO\nelectrophoresis\tO\ngels\tO\n.\tO\n\nDelayed\tO\nanemia\tB-Disease\nafter\tO\ntreatment\tO\nwith\tO\ninjectable\tO\nartesunate\tB-Chemical\nin\tO\nthe\tO\nDemocratic\tO\nRepublic\tO\nof\tO\nthe\tO\nCongo\tO\n:\tO\na\tO\nmanageable\tO\nissue\tO\n.\tO\n\nCases\tO\nof\tO\ndelayed\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nhave\tO\nbeen\tO\ndescribed\tO\nafter\tO\ntreatment\tO\nwith\tO\ninjectable\tO\nartesunate\tB-Chemical\n,\tO\nthe\tO\ncurrent\tO\nWorld\tO\nHealth\tO\nOrganization\tO\n(\tO\nWHO\tO\n)\tO\n-\tO\nrecommended\tO\nfirst\tO\n-\tO\nline\tO\ndrug\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nsevere\tO\nmalaria\tB-Disease\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n350\tO\npatients\tO\n(\tO\n215\tO\n[\tO\n61\tO\n.\tO\n4\tO\n%\tO\n]\tO\n<\tO\n5\tO\nyears\tO\nof\tO\nage\tO\nand\tO\n135\tO\n[\tO\n38\tO\n.\tO\n6\tO\n%\tO\n]\tO\n>\tO\n5\tO\nyears\tO\nof\tO\nage\tO\n)\tO\nwere\tO\nfollowed\tO\n-\tO\nup\tO\nafter\tO\ntreatment\tO\nwith\tO\ninjectable\tO\nartesunate\tB-Chemical\nfor\tO\nsevere\tO\nmalaria\tB-Disease\nin\tO\nhospitals\tO\nand\tO\nhealth\tO\ncenters\tO\nof\tO\nthe\tO\nDemocratic\tO\nRepublic\tO\nof\tO\nthe\tO\nCongo\tO\n.\tO\n\nComplete\tO\nseries\tO\nof\tO\nhemoglobin\tO\n(\tO\nHb\tO\n)\tO\nmeasurements\tO\nwere\tO\navailable\tO\nfor\tO\n201\tO\npatients\tO\n.\tO\n\nA\tO\ndecrease\tO\nin\tO\nHb\tO\nlevels\tO\nbetween\tO\n2\tO\nand\tO\n5\tO\ng\tO\n/\tO\ndL\tO\nwas\tO\ndetected\tO\nin\tO\n23\tO\n(\tO\n11\tO\n.\tO\n4\tO\n%\tO\n)\tO\npatients\tO\nduring\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n.\tO\n\nFor\tO\nfive\tO\npatients\tO\n,\tO\nHb\tO\nlevels\tO\ndecreased\tO\nbelow\tO\n5\tO\ng\tO\n/\tO\ndL\tO\nduring\tO\nat\tO\nleast\tO\none\tO\nfollow\tO\n-\tO\nup\tO\nvisit\tO\n.\tO\n\nAll\tO\ncases\tO\nof\tO\ndelayed\tO\nanemia\tB-Disease\nwere\tO\nclinically\tO\nmanageable\tO\nand\tO\nresolved\tO\nwithin\tO\none\tO\nmonth\tO\n.\tO\n\nRegulation\tO\nof\tO\nsignal\tO\ntransducer\tO\nand\tO\nactivator\tO\nof\tO\ntranscription\tO\n3\tO\nand\tO\napoptotic\tO\npathways\tO\nby\tO\nbetaine\tB-Chemical\nattenuates\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\ninvestigate\tO\nthe\tO\ncardioprotective\tO\neffects\tO\nof\tO\nbetaine\tB-Chemical\non\tO\nacute\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\ninduced\tO\nexperimentally\tO\nin\tO\nrats\tO\nfocusing\tO\non\tO\nregulation\tO\nof\tO\nsignal\tO\ntransducer\tO\nand\tO\nactivator\tO\nof\tO\ntranscription\tO\n3\tO\n(\tO\nSTAT3\tO\n)\tO\nand\tO\napoptotic\tO\npathways\tO\nas\tO\nthe\tO\npotential\tO\nmechanism\tO\nunderlying\tO\nthe\tO\ndrug\tO\neffect\tO\n.\tO\n\nMale\tO\nSprague\tO\nDawley\tO\nrats\tO\nwere\tO\ntreated\tO\nwith\tO\nbetaine\tB-Chemical\n(\tO\n100\tO\n,\tO\n200\tO\n,\tO\nand\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\norally\tO\nfor\tO\n40\tO\ndays\tO\n.\tO\n\nAcute\tO\nmyocardial\tB-Disease\nischemic\tI-Disease\ninjury\tI-Disease\nwas\tO\ninduced\tO\nin\tO\nrats\tO\nby\tO\nsubcutaneous\tO\ninjection\tO\nof\tO\nisoproterenol\tB-Chemical\n(\tO\n85\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nfor\tO\ntwo\tO\nconsecutive\tO\ndays\tO\n.\tO\n\nSerum\tO\ncardiac\tO\nmarker\tO\nenzyme\tO\n,\tO\nhistopathological\tO\nvariables\tO\nand\tO\nexpression\tO\nof\tO\nprotein\tO\nlevels\tO\nwere\tO\nanalyzed\tO\n.\tO\n\nOral\tO\nadministration\tO\nof\tO\nbetaine\tB-Chemical\n(\tO\n200\tO\nand\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nsignificantly\tO\nreduced\tO\nthe\tO\nlevel\tO\nof\tO\ncardiac\tO\nmarker\tO\nenzyme\tO\nin\tO\nthe\tO\nserum\tO\nand\tO\nprevented\tO\nleft\tO\nventricular\tB-Disease\nremodeling\tI-Disease\n.\tO\n\nWestern\tO\nblot\tO\nanalysis\tO\nshowed\tO\nthat\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nphosphorylation\tO\nof\tO\nSTAT3\tO\nwas\tO\nmaintained\tO\nor\tO\nfurther\tO\nenhanced\tO\nby\tO\nbetaine\tB-Chemical\ntreatment\tO\nin\tO\nmyocardium\tO\n.\tO\n\nFurthermore\tO\n,\tO\nbetaine\tB-Chemical\n(\tO\n200\tO\nand\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ntreatment\tO\nincreased\tO\nthe\tO\nventricular\tO\nexpression\tO\nof\tO\nBcl\tO\n-\tO\n2\tO\nand\tO\nreduced\tO\nthe\tO\nlevel\tO\nof\tO\nBax\tO\n,\tO\ntherefore\tO\ncausing\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nthe\tO\nratio\tO\nof\tO\nBcl\tO\n-\tO\n2\tO\n/\tO\nBax\tO\n.\tO\n\nThe\tO\nprotective\tO\nrole\tO\nof\tO\nbetaine\tB-Chemical\non\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nwas\tO\nfurther\tO\nconfirmed\tO\nby\tO\nhistopathological\tO\nexamination\tO\n.\tO\n\nIn\tO\nsummary\tO\n,\tO\nour\tO\nresults\tO\nshowed\tO\nthat\tO\nbetaine\tB-Chemical\npretreatment\tO\nattenuated\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\nvia\tO\nthe\tO\nregulation\tO\nof\tO\nSTAT3\tO\nand\tO\napoptotic\tO\npathways\tO\n.\tO\n\nQuetiapine\tB-Chemical\n-\tO\ninduced\tO\nneutropenia\tB-Disease\nin\tO\na\tO\nbipolar\tB-Disease\npatient\tO\nwith\tO\nhepatocellular\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nQuetiapine\tB-Chemical\nis\tO\na\tO\ndibenzothiazepine\tO\nderivative\tO\n,\tO\nsimilar\tO\nto\tO\nclozapine\tB-Chemical\n,\tO\nwhich\tO\nhas\tO\nthe\tO\nhighest\tO\nrisk\tO\nof\tO\ncausing\tO\nblood\tB-Disease\ndyscrasias\tI-Disease\n,\tO\nespecially\tO\nneutropenia\tB-Disease\n.\tO\n\nThere\tO\nare\tO\nsome\tO\ncase\tO\nreports\tO\nabout\tO\nthis\tO\nside\tO\neffect\tO\nof\tO\nquetiapine\tB-Chemical\n,\tO\nbut\tO\npossible\tO\nrisk\tO\nfactors\tO\nare\tO\nseldom\tO\ndiscussed\tO\nand\tO\nidentified\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\na\tO\npatient\tO\nwith\tO\nhepatocellular\tB-Disease\ncarcinoma\tI-Disease\nthat\tO\ndeveloped\tO\nneutropenia\tB-Disease\nafter\tO\ntreatment\tO\nwith\tO\nquetiapine\tB-Chemical\nis\tO\ndescribed\tO\nhere\tO\n.\tO\n\nCASE\tO\nREPORT\tO\n:\tO\nA\tO\n62\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nTaiwanese\tO\nwidow\tO\nwith\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\nwas\tO\ndiagnosed\tO\nwith\tO\nhepatocellular\tB-Disease\ncarcinoma\tI-Disease\nat\tO\nage\tO\n60\tO\n.\tO\n\nShe\tO\ndeveloped\tO\nleucopenia\tB-Disease\nafter\tO\nbeing\tO\ntreated\tO\nwith\tO\nquetiapine\tB-Chemical\n.\tO\n\nAfter\tO\nquetiapine\tB-Chemical\nwas\tO\ndiscontinued\tO\n,\tO\nher\tO\nwhite\tO\nblood\tO\ncell\tO\ncount\tO\nreturned\tO\nto\tO\nnormal\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAlthough\tO\nneutropenia\tB-Disease\nis\tO\nnot\tO\na\tO\ncommon\tO\nside\tO\neffect\tO\nof\tO\nquetiapine\tB-Chemical\n,\tO\nphysicians\tO\nshould\tO\nbe\tO\ncautious\tO\nabout\tO\nits\tO\npresentation\tO\nand\tO\nassociated\tO\nrisk\tO\nfactors\tO\n.\tO\n\nHepatic\tB-Disease\ndysfunction\tI-Disease\nmay\tO\nbe\tO\none\tO\nof\tO\nthe\tO\npossible\tO\nrisk\tO\nfactors\tO\n,\tO\nand\tO\nconcomitant\tO\nfever\tB-Disease\nmay\tO\nbe\tO\na\tO\ndiagnostic\tO\nmarker\tO\nfor\tO\nadverse\tO\nreaction\tO\nto\tO\nquetiapine\tB-Chemical\n.\tO\n\nLateral\tO\nantebrachial\tO\ncutaneous\tO\nneuropathy\tB-Disease\nafter\tO\nsteroid\tB-Chemical\ninjection\tO\nat\tO\nlateral\tO\nepicondyle\tO\n.\tO\n\nBACKGROUND\tO\nAND\tO\nOBJECTIVES\tO\n:\tO\nThis\tO\nreport\tO\naimed\tO\nto\tO\npresent\tO\na\tO\ncase\tO\nof\tO\nlateral\tO\nantebrachial\tO\ncutaneous\tO\nneuropathy\tB-Disease\n(\tO\nLACNP\tO\n)\tO\nthat\tO\noccurred\tO\nafter\tO\na\tO\nsteroid\tB-Chemical\ninjection\tO\nin\tO\nthe\tO\nlateral\tO\nepicondyle\tO\nto\tO\ntreat\tO\nlateral\tB-Disease\nepicondylitis\tI-Disease\nin\tO\na\tO\n40\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\n.\tO\n\nMATERIAL\tO\nAND\tO\nMETHOD\tO\n:\tO\nA\tO\n40\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\npresented\tO\nwith\tO\ndecreased\tO\nsensation\tO\nand\tO\nparesthesia\tB-Disease\nover\tO\nher\tO\nright\tO\nlateral\tO\nforearm\tO\n;\tO\nthe\tO\nparesthesia\tB-Disease\nhad\tO\noccurred\tO\nafter\tO\na\tO\nsteroid\tB-Chemical\ninjection\tO\nin\tO\nthe\tO\nright\tO\nlateral\tO\nepicondyle\tO\n3\tO\nmonths\tO\nbefore\tO\n.\tO\n\nHer\tO\nsensation\tO\nof\tO\nlight\tO\ntouch\tO\nand\tO\npain\tB-Disease\nwas\tO\ndiminished\tO\nover\tO\nthe\tO\nlateral\tO\nside\tO\nof\tO\nthe\tO\nright\tO\nforearm\tO\nand\tO\nwrist\tO\narea\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nsensory\tO\naction\tO\npotential\tO\namplitude\tO\nof\tO\nthe\tO\nright\tO\nlateral\tO\nantebrachial\tO\ncutaneous\tO\nnerve\tO\n(\tO\nLACN\tO\n)\tO\n(\tO\n6\tO\n.\tO\n2\tO\nuV\tO\n)\tO\nwas\tO\nlower\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\nleft\tO\n(\tO\n13\tO\n.\tO\n1\tO\nuV\tO\n)\tO\n.\tO\n\nThe\tO\ndifference\tO\nof\tO\namplitude\tO\nbetween\tO\nboth\tO\nsides\tO\nwas\tO\nsignificant\tO\nbecause\tO\nthere\tO\nwas\tO\nmore\tO\nthan\tO\na\tO\n50\tO\n%\tO\nreduction\tO\n.\tO\n\nShe\tO\nwas\tO\ndiagnosed\tO\nwith\tO\nright\tO\nLACNP\tO\n(\tO\nmainly\tO\naxonal\tO\ninvolvement\tO\n)\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\nthe\tO\nclinical\tO\nmanifestation\tO\nand\tO\nthe\tO\nelectrodiagnostic\tO\nfindings\tO\n.\tO\n\nHer\tO\nsymptoms\tO\nimproved\tO\nthrough\tO\nphysical\tO\ntherapy\tO\nbut\tO\npersisted\tO\nto\tO\nsome\tO\ndegree\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nreport\tO\ndescribes\tO\nthe\tO\ncase\tO\nof\tO\na\tO\nwoman\tO\nwith\tO\nLACNP\tO\nthat\tO\ndeveloped\tO\nafter\tO\na\tO\nsteroid\tB-Chemical\ninjection\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nlateral\tB-Disease\nepicondylitis\tI-Disease\n.\tO\n\nAn\tO\nelectrodiagnostic\tO\nstudy\tO\n,\tO\nincluding\tO\na\tO\nnerve\tO\nconduction\tO\nstudy\tO\nof\tO\nthe\tO\nLACN\tO\n,\tO\nwas\tO\nhelpful\tO\nto\tO\ndiagnose\tO\nright\tO\nLACNP\tO\nand\tO\nto\tO\nfind\tO\nthe\tO\npassage\tO\nof\tO\nthe\tO\nLACN\tO\non\tO\nthe\tO\nlateral\tO\nepicondyle\tO\n.\tO\n\nCurcumin\tB-Chemical\nprevents\tO\nmaleate\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n:\tO\nrelation\tO\nto\tO\nhemodynamic\tO\nalterations\tO\n,\tO\noxidative\tO\nstress\tO\n,\tO\nmitochondrial\tO\noxygen\tB-Chemical\nconsumption\tO\nand\tO\nactivity\tO\nof\tO\nrespiratory\tO\ncomplex\tO\nI\tO\n.\tO\n\nThe\tO\npotential\tO\nprotective\tO\neffect\tO\nof\tO\nthe\tO\ndietary\tO\nantioxidant\tO\ncurcumin\tB-Chemical\n(\tO\n120\tO\nmg\tO\n/\tO\nKg\tO\n/\tO\nday\tO\nfor\tO\n6\tO\ndays\tO\n)\tO\nagainst\tO\nthe\tO\nrenal\tB-Disease\ninjury\tI-Disease\ninduced\tO\nby\tO\nmaleate\tB-Chemical\nwas\tO\nevaluated\tO\n.\tO\n\nTubular\tO\nproteinuria\tB-Disease\nand\tO\noxidative\tO\nstress\tO\nwere\tO\ninduced\tO\nby\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\nmaleate\tB-Chemical\n(\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nin\tO\nrats\tO\n.\tO\n\nMaleate\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ninjury\tI-Disease\nincluded\tO\nincrease\tO\nin\tO\nrenal\tO\nvascular\tO\nresistance\tO\nand\tO\nin\tO\nthe\tO\nurinary\tO\nexcretion\tO\nof\tO\ntotal\tO\nprotein\tO\n,\tO\nglucose\tB-Chemical\n,\tO\nsodium\tB-Chemical\n,\tO\nneutrophil\tO\ngelatinase\tO\n-\tO\nassociated\tO\nlipocalin\tO\n(\tO\nNGAL\tO\n)\tO\nand\tO\nN\tO\n-\tO\nacetyl\tO\nb\tO\n-\tO\nD\tO\n-\tO\nglucosaminidase\tO\n(\tO\nNAG\tO\n)\tO\n,\tO\nupregulation\tO\nof\tO\nkidney\tB-Disease\ninjury\tI-Disease\nmolecule\tO\n(\tO\nKIM\tO\n)\tO\n-\tO\n1\tO\n,\tO\ndecrease\tO\nin\tO\nrenal\tO\nblood\tO\nflow\tO\nand\tO\nclaudin\tO\n-\tO\n2\tO\nexpression\tO\nbesides\tO\nof\tO\nnecrosis\tB-Disease\nand\tO\napoptosis\tO\nof\tO\ntubular\tO\ncells\tO\non\tO\n24\tO\nh\tO\n.\tO\n\nOxidative\tO\nstress\tO\nwas\tO\ndetermined\tO\nby\tO\nmeasuring\tO\nthe\tO\noxidation\tO\nof\tO\nlipids\tO\nand\tO\nproteins\tO\nand\tO\ndiminution\tO\nin\tO\nrenal\tO\nNrf2\tO\nlevels\tO\n.\tO\n\nStudies\tO\nwere\tO\nalso\tO\nconducted\tO\nin\tO\nrenal\tO\nepithelial\tO\nLLC\tO\n-\tO\nPK1\tO\ncells\tO\nand\tO\nin\tO\nmitochondria\tO\nisolated\tO\nfrom\tO\nkidneys\tO\nof\tO\nall\tO\nthe\tO\nexperimental\tO\ngroups\tO\n.\tO\n\nMaleate\tB-Chemical\ninduced\tO\ncell\tO\ndamage\tO\nand\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\n(\tO\nROS\tO\n)\tO\nproduction\tO\nin\tO\nLLC\tO\n-\tO\nPK1\tO\ncells\tO\nin\tO\nculture\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nmaleate\tB-Chemical\ntreatment\tO\nreduced\tO\noxygen\tB-Chemical\nconsumption\tO\nin\tO\nADP\tB-Chemical\n-\tO\nstimulated\tO\nmitochondria\tO\nand\tO\ndiminished\tO\nrespiratory\tO\ncontrol\tO\nindex\tO\nwhen\tO\nusing\tO\nmalate\tB-Chemical\n/\tO\nglutamate\tB-Chemical\nas\tO\nsubstrate\tO\n.\tO\n\nThe\tO\nactivities\tO\nof\tO\nboth\tO\ncomplex\tO\nI\tO\nand\tO\naconitase\tO\nwere\tO\nalso\tO\ndiminished\tO\n.\tO\n\nAll\tO\nthe\tO\nabove\tO\n-\tO\ndescribed\tO\nalterations\tO\nwere\tO\nprevented\tO\nby\tO\ncurcumin\tB-Chemical\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\ncurcumin\tB-Chemical\nis\tO\nable\tO\nto\tO\nattenuate\tO\nin\tO\nvivo\tO\nmaleate\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\nand\tO\nin\tO\nvitro\tO\ncell\tO\ndamage\tO\n.\tO\n\nThe\tO\nin\tO\nvivo\tO\nprotection\tO\nwas\tO\nassociated\tO\nto\tO\nthe\tO\nprevention\tO\nof\tO\noxidative\tO\nstress\tO\nand\tO\npreservation\tO\nof\tO\nmitochondrial\tO\noxygen\tB-Chemical\nconsumption\tO\nand\tO\nactivity\tO\nof\tO\nrespiratory\tO\ncomplex\tO\nI\tO\n,\tO\nand\tO\nthe\tO\nin\tO\nvitro\tO\nprotection\tO\nwas\tO\nassociated\tO\nto\tO\nthe\tO\nprevention\tO\nof\tO\nROS\tO\nproduction\tO\n.\tO\n\nAnticonvulsant\tO\nactions\tO\nof\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\non\tO\nthe\tO\nlithium\tB-Chemical\n-\tO\npilocarpine\tB-Chemical\nmodel\tO\nof\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n,\tO\na\tO\nnoncompetitive\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nreceptor\tO\nantagonist\tO\n,\tO\nwas\tO\ntested\tO\nfor\tO\nanticonvulsant\tO\neffects\tO\nin\tO\nrats\tO\nusing\tO\ntwo\tO\nseizure\tB-Disease\nmodels\tO\n,\tO\ncoadministration\tO\nof\tO\nlithium\tB-Chemical\nand\tO\npilocarpine\tB-Chemical\nand\tO\nadministration\tO\nof\tO\na\tO\nhigh\tO\ndose\tO\nof\tO\npilocarpine\tB-Chemical\nalone\tO\n.\tO\n\nThree\tO\nmajor\tO\nresults\tO\nare\tO\nreported\tO\n.\tO\n\nFirst\tO\n,\tO\npretreatment\tO\nwith\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\nproduced\tO\nan\tO\neffective\tO\nand\tO\ndose\tO\n-\tO\ndependent\tO\nanticonvulsant\tO\naction\tO\nwith\tO\nthe\tO\nlithium\tB-Chemical\n-\tO\npilocarpine\tB-Chemical\nmodel\tO\nbut\tO\nnot\tO\nwith\tO\nrats\tO\ntreated\tO\nwith\tO\npilocarpine\tB-Chemical\nalone\tO\n,\tO\nsuggesting\tO\nthat\tO\ndifferent\tO\nbiochemical\tO\nmechanisms\tO\ncontrol\tO\nseizures\tB-Disease\nin\tO\nthese\tO\ntwo\tO\nmodels\tO\n.\tO\n\nSecond\tO\n,\tO\nthe\tO\nanticonvulsant\tO\neffect\tO\nof\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\nin\tO\nthe\tO\nlithium\tB-Chemical\n-\tO\npilocarpine\tB-Chemical\nmodel\tO\nonly\tO\noccurred\tO\nafter\tO\ninitial\tO\nperiods\tO\nof\tO\nseizure\tB-Disease\nactivity\tO\n.\tO\n\nThis\tO\nobservation\tO\nis\tO\nsuggested\tO\nto\tO\nbe\tO\nan\tO\nin\tO\nvivo\tO\ndemonstration\tO\nof\tO\nthe\tO\nconclusion\tO\nderived\tO\nfrom\tO\nin\tO\nvitro\tO\nexperiments\tO\nthat\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\nbinding\tO\nrequires\tO\nagonist\tO\n-\tO\ninduced\tO\nopening\tO\nof\tO\nthe\tO\nchannel\tO\nsites\tO\nof\tO\nthe\tO\nNMDA\tB-Chemical\nreceptor\tO\n.\tO\n\nThird\tO\n,\tO\nalthough\tO\nit\tO\nis\tO\nrelatively\tO\neasy\tO\nto\tO\nblock\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\nlithium\tB-Chemical\nand\tO\npilocarpine\tB-Chemical\nby\tO\nadministration\tO\nof\tO\nanticonvulsants\tO\nprior\tO\nto\tO\npilocarpine\tB-Chemical\n,\tO\nit\tO\nis\tO\nmore\tO\ndifficult\tO\nto\tO\nterminate\tO\nongoing\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nand\tO\nblock\tO\nthe\tO\nlethality\tO\nof\tO\nthe\tO\nseizures\tB-Disease\n.\tO\n\nAdministration\tO\nof\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n30\tO\nor\tO\n60\tO\nmin\tO\nafter\tO\npilocarpine\tB-Chemical\n,\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nduring\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n,\tO\ngradually\tO\nreduced\tO\nelectrical\tO\nand\tO\nbehavioral\tO\nseizure\tB-Disease\nactivity\tO\nand\tO\ngreatly\tO\nenhanced\tO\nthe\tO\nsurvival\tO\nrate\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nactivation\tO\nof\tO\nNMDA\tB-Chemical\nreceptors\tO\nplays\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nand\tO\nbrain\tB-Disease\ndamage\tI-Disease\nin\tO\nthe\tO\nlithium\tB-Chemical\n-\tO\npilocarpine\tB-Chemical\nmodel\tO\n.\tO\n\nThis\tO\nwas\tO\nfurther\tO\nsupported\tO\nby\tO\nresults\tO\nshowing\tO\nthat\tO\nnonconvulsive\tO\ndoses\tO\nof\tO\nNMDA\tB-Chemical\nand\tO\npilocarpine\tB-Chemical\nwere\tO\nsynergistic\tO\n,\tO\nresulting\tO\nin\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nand\tO\nsubsequent\tO\nmortality\tO\n.\tO\n\nContinuous\tO\ninfusion\tO\ntobramycin\tB-Chemical\ncombined\tO\nwith\tO\ncarbenicillin\tB-Chemical\nfor\tO\ninfections\tB-Disease\nin\tO\ncancer\tB-Disease\npatients\tO\n.\tO\n\nThe\tO\ncure\tO\nrate\tO\nof\tO\ninfections\tB-Disease\nin\tO\ncancer\tB-Disease\npatients\tO\nis\tO\nadversely\tO\naffected\tO\nby\tO\nneutropenia\tB-Disease\n(\tO\nless\tO\nthan\tO\n1\tO\n,\tO\n000\tO\n/\tO\nmm3\tO\n)\tO\n.\tO\n\nIn\tO\nparticular\tO\n,\tO\npatients\tO\nwith\tO\nsevere\tO\nneutropenia\tB-Disease\n(\tO\nless\tO\nthan\tO\n100\tO\n/\tO\nmm3\tO\n)\tO\nhave\tO\nshown\tO\na\tO\npoor\tO\nresponse\tO\nto\tO\nantibiotics\tO\n.\tO\n\nTo\tO\novercome\tO\nthe\tO\nadverse\tO\neffects\tO\nof\tO\nneutropenia\tB-Disease\n,\tO\ntobramycin\tB-Chemical\nwas\tO\ngiven\tO\nby\tO\ncontinuous\tO\ninfusion\tO\nand\tO\ncombined\tO\nwith\tO\nintermittent\tO\ncarbenicillin\tB-Chemical\n.\tO\n\nTobramycin\tB-Chemical\nwas\tO\ngiven\tO\nto\tO\na\tO\ntotal\tO\ndaily\tO\ndose\tO\nof\tO\n300\tO\nmg\tO\n/\tO\nm2\tO\nand\tO\ncarbenicillin\tB-Chemical\nwas\tO\ngiven\tO\nat\tO\na\tO\ndose\tO\nof\tO\n5\tO\ngm\tO\nevery\tO\nfour\tO\nhours\tO\n.\tO\n\nThere\tO\nwere\tO\n125\tO\ninfectious\tO\nepisodes\tO\nin\tO\n116\tO\ncancer\tB-Disease\npatients\tO\nreceiving\tO\nmyelosuppressive\tO\nchemotherapy\tO\n.\tO\n\nThe\tO\noverall\tO\ncure\tO\nrate\tO\nwas\tO\n70\tO\n%\tO\n.\tO\n\nPneumonia\tB-Disease\nwas\tO\nthe\tO\nmost\tO\ncommon\tO\ninfection\tB-Disease\nand\tO\n61\tO\n%\tO\nof\tO\n59\tO\nepisodes\tO\nwere\tO\ncured\tO\n.\tO\n\nGram\tO\n-\tO\nnegative\tO\nbacilli\tO\nwere\tO\nthe\tO\nmost\tO\ncommon\tO\ncausative\tO\norganisms\tO\nand\tO\n69\tO\n%\tO\nof\tO\nthese\tO\ninfections\tB-Disease\nwere\tO\ncured\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\npathogen\tO\nwas\tO\nKlebsiella\tO\npneumoniae\tB-Disease\nand\tO\nthis\tO\n,\tO\ntogether\tO\nwith\tO\nEscherichia\tO\ncoli\tO\nand\tO\nPseudomonas\tO\naeruginosa\tO\n,\tO\naccounted\tO\nfor\tO\n74\tO\n%\tO\nof\tO\nall\tO\ngram\tB-Disease\n-\tI-Disease\nnegative\tI-Disease\nbacillary\tI-Disease\ninfections\tI-Disease\n.\tO\n\nResponse\tO\nwas\tO\nnot\tO\ninfluenced\tO\nby\tO\nthe\tO\ninitial\tO\nneutrophil\tO\ncount\tO\n,\tO\nwith\tO\na\tO\n62\tO\n%\tO\ncure\tO\nrate\tO\nfor\tO\n39\tO\nepisodes\tO\nassociated\tO\nwith\tO\nsevere\tO\nneutropenia\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nfailure\tO\nof\tO\nthe\tO\nneutrophil\tO\ncount\tO\nto\tO\nincrease\tO\nduring\tO\ntherapy\tO\nadversely\tO\naffected\tO\nresponse\tO\n.\tO\n\nAzotemia\tB-Disease\nwas\tO\nthe\tO\nmajor\tO\nside\tO\neffect\tO\nrecognized\tO\n,\tO\nand\tO\nit\tO\noccurred\tO\nin\tO\n11\tO\n%\tO\nof\tO\nepisodes\tO\n.\tO\n\nMajor\tO\nazotemia\tB-Disease\n(\tO\nserum\tO\ncreatinine\tB-Chemical\ngreater\tO\nthan\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\nor\tO\nBUN\tO\ngreater\tO\nthan\tO\n50\tO\nmg\tO\n/\tO\ndl\tO\n)\tO\noccurred\tO\nin\tO\nonly\tO\n2\tO\n%\tO\n.\tO\n\nAzotemia\tB-Disease\nwas\tO\nnot\tO\nrelated\tO\nto\tO\nduration\tO\nof\tO\ntherapy\tO\nor\tO\nserum\tO\ntobramycin\tB-Chemical\nconcentration\tO\n.\tO\n\nThis\tO\nantibiotic\tO\nregimen\tO\nshowed\tO\nboth\tO\ntherapeutic\tO\nefficacy\tO\nand\tO\nacceptable\tO\nrenal\tB-Disease\ntoxicity\tI-Disease\nfor\tO\nthese\tO\npatients\tO\n.\tO\n\nIncidence\tO\nof\tO\nsolid\tO\ntumours\tB-Disease\namong\tO\npesticide\tO\napplicators\tO\nexposed\tO\nto\tO\nthe\tO\norganophosphate\tB-Chemical\ninsecticide\tO\ndiazinon\tB-Chemical\nin\tO\nthe\tO\nAgricultural\tO\nHealth\tO\nStudy\tO\n:\tO\nan\tO\nupdated\tO\nanalysis\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nDiazinon\tB-Chemical\n,\tO\na\tO\ncommon\tO\norganophosphate\tB-Chemical\ninsecticide\tO\nwith\tO\ngenotoxic\tO\nproperties\tO\n,\tO\nwas\tO\npreviously\tO\nassociated\tO\nwith\tO\nlung\tB-Disease\ncancer\tI-Disease\nin\tO\nthe\tO\nAgricultural\tO\nHealth\tO\nStudy\tO\n(\tO\nAHS\tO\n)\tO\ncohort\tO\n,\tO\nbut\tO\nfew\tO\nother\tO\nepidemiological\tO\nstudies\tO\nhave\tO\nexamined\tO\ndiazinon\tB-Chemical\n-\tO\nassociated\tO\ncancer\tB-Disease\nrisk\tO\n.\tO\n\nWe\tO\nused\tO\nupdated\tO\ndiazinon\tB-Chemical\nexposure\tO\nand\tO\ncancer\tB-Disease\nincidence\tO\ninformation\tO\nto\tO\nevaluate\tO\nsolid\tO\ntumour\tB-Disease\nrisk\tO\nin\tO\nthe\tO\nAHS\tO\n.\tO\n\nMETHODS\tO\n:\tO\nMale\tO\npesticide\tO\napplicators\tO\nin\tO\nIowa\tO\nand\tO\nNorth\tO\nCarolina\tO\nreported\tO\nlifetime\tO\ndiazinon\tB-Chemical\nuse\tO\nat\tO\nenrolment\tO\n(\tO\n1993\tO\n-\tO\n1997\tO\n)\tO\nand\tO\nfollow\tO\n-\tO\nup\tO\n(\tO\n1998\tO\n-\tO\n2005\tO\n)\tO\n;\tO\ncancer\tB-Disease\nincidence\tO\nwas\tO\nassessed\tO\nthrough\tO\n2010\tO\n(\tO\nNorth\tO\nCarolina\tO\n)\tO\n/\tO\n2011\tO\n(\tO\nIowa\tO\n)\tO\n.\tO\n\nAmong\tO\napplicators\tO\nwith\tO\nusage\tO\ninformation\tO\nsufficient\tO\nto\tO\nevaluate\tO\nexposure\tO\n-\tO\nresponse\tO\npatterns\tO\n,\tO\nwe\tO\nused\tO\nPoisson\tO\nregression\tO\nto\tO\nestimate\tO\nadjusted\tO\nrate\tO\nratios\tO\n(\tO\nRRs\tO\n)\tO\nand\tO\n95\tO\n%\tO\nCI\tO\nfor\tO\ncancer\tB-Disease\nsites\tO\nwith\tO\n>\tO\n10\tO\nexposed\tO\ncases\tO\nfor\tO\nboth\tO\nlifetime\tO\n(\tO\nLT\tO\n)\tO\nexposure\tO\ndays\tO\nand\tO\nintensity\tO\n-\tO\nweighted\tO\n(\tO\nIW\tO\n)\tO\nlifetime\tO\nexposure\tO\ndays\tO\n(\tO\naccounting\tO\nfor\tO\nfactors\tO\nimpacting\tO\nexposure\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nobserved\tO\nelevated\tO\nlung\tB-Disease\ncancer\tI-Disease\nrisks\tO\n(\tO\nN\tO\n=\tO\n283\tO\n)\tO\namong\tO\napplicators\tO\nwith\tO\nthe\tO\ngreatest\tO\nnumber\tO\nof\tO\nLT\tO\n(\tO\nRR\tO\n=\tO\n1\tO\n.\tO\n60\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n11\tO\nto\tO\n2\tO\n.\tO\n31\tO\n;\tO\nPtrend\tO\n=\tO\n0\tO\n.\tO\n02\tO\n)\tO\nand\tO\nIW\tO\ndays\tO\nof\tO\ndiazinon\tB-Chemical\nuse\tO\n(\tO\nRR\tO\n=\tO\n1\tO\n.\tO\n41\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n98\tO\nto\tO\n2\tO\n.\tO\n04\tO\n;\tO\nPtrend\tO\n=\tO\n0\tO\n.\tO\n08\tO\n)\tO\n.\tO\n\nKidney\tB-Disease\ncancer\tI-Disease\n(\tO\nN\tO\n=\tO\n94\tO\n)\tO\nrisks\tO\nwere\tO\nnon\tO\n-\tO\nsignificantly\tO\nelevated\tO\n(\tO\nRRLT\tO\ndays\tO\n=\tO\n1\tO\n.\tO\n77\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n90\tO\nto\tO\n3\tO\n.\tO\n51\tO\n;\tO\nPtrend\tO\n=\tO\n0\tO\n.\tO\n09\tO\n;\tO\nRRIW\tO\ndays\tO\n1\tO\n.\tO\n37\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n64\tO\nto\tO\n2\tO\n.\tO\n92\tO\n;\tO\nPtrend\tO\n=\tO\n0\tO\n.\tO\n50\tO\n)\tO\n,\tO\nas\tO\nwere\tO\nrisks\tO\nfor\tO\naggressive\tO\nprostate\tB-Disease\ncancer\tI-Disease\n(\tO\nN\tO\n=\tO\n656\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nOur\tO\nupdated\tO\nevaluation\tO\nof\tO\ndiazinon\tB-Chemical\nprovides\tO\nadditional\tO\nevidence\tO\nof\tO\nan\tO\nassociation\tO\nwith\tO\nlung\tB-Disease\ncancer\tI-Disease\nrisk\tO\n.\tO\n\nNewly\tO\nidentified\tO\nlinks\tO\nto\tO\nkidney\tB-Disease\ncancer\tI-Disease\nand\tO\nassociations\tO\nwith\tO\naggressive\tO\nprostate\tB-Disease\ncancer\tI-Disease\nrequire\tO\nfurther\tO\nevaluation\tO\n.\tO\n\nAssociations\tO\nof\tO\nOzone\tB-Chemical\nand\tO\nPM2\tO\n.\tO\n5\tO\nConcentrations\tO\nWith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nAmong\tO\nParticipants\tO\nin\tO\nthe\tO\nAgricultural\tO\nHealth\tO\nStudy\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThis\tO\nstudy\tO\ndescribes\tO\nassociations\tO\nof\tO\nozone\tB-Chemical\nand\tO\nfine\tO\nparticulate\tB-Chemical\nmatter\tI-Chemical\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nobserved\tO\namong\tO\nfarmers\tO\nin\tO\nNorth\tO\nCarolina\tO\nand\tO\nIowa\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nused\tO\nlogistic\tO\nregression\tO\nto\tO\ndetermine\tO\nthe\tO\nassociations\tO\nof\tO\nthese\tO\npollutants\tO\nwith\tO\nself\tO\n-\tO\nreported\tO\n,\tO\ndoctor\tO\n-\tO\ndiagnosed\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nDaily\tO\npredicted\tO\npollutant\tO\nconcentrations\tO\nwere\tO\nused\tO\nto\tO\nderive\tO\nsurrogates\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\nexposure\tO\nand\tO\nlink\tO\nthem\tO\nto\tO\nstudy\tO\nparticipants\tO\n'\tO\ngeocoded\tO\naddresses\tO\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nobserved\tO\npositive\tO\nassociations\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nwith\tO\nozone\tB-Chemical\n(\tO\nodds\tO\nratio\tO\n=\tO\n1\tO\n.\tO\n39\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n98\tO\nto\tO\n1\tO\n.\tO\n98\tO\n)\tO\nand\tO\nfine\tO\nparticulate\tB-Chemical\nmatter\tI-Chemical\n(\tO\nodds\tO\nratio\tO\n=\tO\n1\tO\n.\tO\n34\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n93\tO\nto\tO\n1\tO\n.\tO\n93\tO\n)\tO\nin\tO\nNorth\tO\nCarolina\tO\nbut\tO\nnot\tO\nin\tO\nIowa\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nplausibility\tO\nof\tO\nan\tO\neffect\tO\nof\tO\nambient\tO\nconcentrations\tO\nof\tO\nthese\tO\npollutants\tO\non\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nrisk\tO\nis\tO\nsupported\tO\nby\tO\nexperimental\tO\ndata\tO\ndemonstrating\tO\ndamage\tO\nto\tO\ndopaminergic\tO\nneurons\tO\nat\tO\nrelevant\tO\nconcentrations\tO\n.\tO\n\nAdditional\tO\nstudies\tO\nare\tO\nneeded\tO\nto\tO\naddress\tO\nuncertainties\tO\nrelated\tO\nto\tO\nconfounding\tO\nand\tO\nto\tO\nexamine\tO\ntemporal\tO\naspects\tO\nof\tO\nthe\tO\nassociations\tO\nwe\tO\nobserved\tO\n.\tO\n\nLow\tO\nfunctional\tO\nprogramming\tO\nof\tO\nrenal\tO\nAT2R\tO\nmediates\tO\nthe\tO\ndevelopmental\tO\norigin\tO\nof\tO\nglomerulosclerosis\tB-Disease\nin\tO\nadult\tO\noffspring\tO\ninduced\tO\nby\tO\nprenatal\tO\ncaffeine\tB-Chemical\nexposure\tO\n.\tO\n\nUNASSIGNED\tO\n:\tO\nOur\tO\nprevious\tO\nstudy\tO\nhas\tO\nindicated\tO\nthat\tO\nprenatal\tO\ncaffeine\tB-Chemical\nexposure\tO\n(\tO\nPCE\tO\n)\tO\ncould\tO\ninduce\tO\nintrauterine\tB-Disease\ngrowth\tI-Disease\nretardation\tI-Disease\n(\tO\nIUGR\tB-Disease\n)\tO\nof\tO\noffspring\tO\n.\tO\n\nRecent\tO\nresearch\tO\nsuggested\tO\nthat\tO\nIUGR\tB-Disease\nis\tO\na\tO\nrisk\tO\nfactor\tO\nfor\tO\nglomerulosclerosis\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nwhether\tO\nPCE\tO\ncould\tO\ninduce\tO\nglomerulosclerosis\tB-Disease\nand\tO\nits\tO\nunderlying\tO\nmechanisms\tO\nremain\tO\nunknown\tO\n.\tO\n\nThis\tO\nstudy\tO\naimed\tO\nto\tO\ndemonstrate\tO\nthe\tO\ninduction\tO\nto\tO\nglomerulosclerosis\tB-Disease\nin\tO\nadult\tO\noffspring\tO\nby\tO\nPCE\tO\nand\tO\nits\tO\nintrauterine\tO\nprogramming\tO\nmechanisms\tO\n.\tO\n\nA\tO\nrat\tO\nmodel\tO\nof\tO\nIUGR\tB-Disease\nwas\tO\nestablished\tO\nby\tO\nPCE\tO\n,\tO\nmale\tO\nfetuses\tO\nand\tO\nadult\tO\noffspring\tO\nat\tO\nthe\tO\nage\tO\nof\tO\npostnatal\tO\nweek\tO\n24\tO\nwere\tO\neuthanized\tO\n.\tO\n\nThe\tO\nresults\tO\nrevealed\tO\nthat\tO\nthe\tO\nadult\tO\noffspring\tO\nkidneys\tO\nin\tO\nthe\tO\nPCE\tO\ngroup\tO\nexhibited\tO\nglomerulosclerosis\tB-Disease\nas\tO\nwell\tO\nas\tO\ninterstitial\tB-Disease\nfibrosis\tI-Disease\n,\tO\naccompanied\tO\nby\tO\nelevated\tO\nlevels\tO\nof\tO\nserum\tO\ncreatinine\tB-Chemical\nand\tO\nurine\tO\nprotein\tO\n.\tO\n\nRenal\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\ntype\tO\n2\tO\n(\tO\nAT2R\tO\n)\tO\ngene\tO\nexpression\tO\nin\tO\nadult\tO\noffspring\tO\nwas\tO\nreduced\tO\nby\tO\nPCE\tO\n,\tO\nwhereas\tO\nthe\tO\nrenal\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\ntype\tO\n1a\tO\n(\tO\nAT1aR\tO\n)\tO\n/\tO\nAT2R\tO\nexpression\tO\nratio\tO\nwas\tO\nincreased\tO\n.\tO\n\nThe\tO\nfetal\tO\nkidneys\tO\nin\tO\nthe\tO\nPCE\tO\ngroup\tO\ndisplayed\tO\nan\tO\nenlarged\tO\nBowman\tO\n'\tO\ns\tO\nspace\tO\nand\tO\na\tO\nshrunken\tO\nglomerular\tO\ntuft\tO\n,\tO\naccompanied\tO\nby\tO\na\tO\nreduced\tO\ncortex\tO\nwidth\tO\nand\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\nnephrogenic\tO\nzone\tO\n/\tO\ncortical\tO\nzone\tO\nratio\tO\n.\tO\n\nObservation\tO\nby\tO\nelectronic\tO\nmicroscope\tO\nrevealed\tO\nstructural\tO\ndamage\tO\nof\tO\npodocytes\tO\n;\tO\nthe\tO\nreduced\tO\nexpression\tO\nlevel\tO\nof\tO\npodocyte\tO\nmarker\tO\ngenes\tO\n,\tO\nnephrin\tO\nand\tO\npodocin\tO\n,\tO\nwas\tO\nalso\tO\ndetected\tO\nby\tO\nq\tO\n-\tO\nPCR\tO\n.\tO\n\nMoreover\tO\n,\tO\nAT2R\tO\ngene\tO\nand\tO\nprotein\tO\nexpressions\tO\nin\tO\nfetal\tO\nkidneys\tO\nwere\tO\ninhibited\tO\nby\tO\nPCE\tO\n,\tO\nassociated\tO\nwith\tO\nthe\tO\nrepression\tO\nof\tO\nthe\tO\ngene\tO\nexpression\tO\nof\tO\nglial\tO\n-\tO\ncell\tO\n-\tO\nline\tO\n-\tO\nderived\tO\nneurotrophic\tO\nfactor\tO\n(\tO\nGDNF\tO\n)\tO\n/\tO\ntyrosine\tB-Chemical\nkinase\tO\nreceptor\tO\n(\tO\nc\tO\n-\tO\nRet\tO\n)\tO\nsignaling\tO\npathway\tO\n.\tO\n\nThese\tO\nresults\tO\ndemonstrated\tO\nthat\tO\nPCE\tO\ncould\tO\ninduce\tO\ndysplasia\tB-Disease\nof\tI-Disease\nfetal\tI-Disease\nkidneys\tI-Disease\nas\tO\nwell\tO\nas\tO\nglomerulosclerosis\tB-Disease\nof\tO\nadult\tO\noffspring\tO\n,\tO\nand\tO\nthe\tO\nlow\tO\nfunctional\tO\nprogramming\tO\nof\tO\nrenal\tO\nAT2R\tO\nmight\tO\nmediate\tO\nthe\tO\ndevelopmental\tO\norigin\tO\nof\tO\nadult\tO\nglomerulosclerosis\tB-Disease\n.\tO\n\n1\tB-Chemical\n,\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nButadiene\tI-Chemical\n,\tO\nCML\tB-Disease\nand\tO\nthe\tO\nt\tO\n(\tO\n9\tO\n:\tO\n22\tO\n)\tO\ntranslocation\tO\n:\tO\nA\tO\nreality\tO\ncheck\tO\n.\tO\n\nUNASSIGNED\tO\n:\tO\nEpidemiological\tO\nstudies\tO\nof\tO\n1\tB-Chemical\n,\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nbutadiene\tI-Chemical\nhave\tO\nsuggest\tO\nthat\tO\nexposures\tO\nto\tO\nhumans\tO\nare\tO\nassociated\tO\nwith\tO\nchronic\tB-Disease\nmyeloid\tI-Disease\nleukemia\tI-Disease\n(\tO\nCML\tB-Disease\n)\tO\n.\tO\n\nCML\tB-Disease\nhas\tO\na\tO\nwell\tO\n-\tO\ndocumented\tO\nassociation\tO\nwith\tO\nionizing\tO\nradiation\tO\n,\tO\nbut\tO\nreports\tO\nof\tO\nassociations\tO\nwith\tO\nchemical\tO\nexposures\tO\nhave\tO\nbeen\tO\nquestioned\tO\n.\tO\n\nIonizing\tO\nradiation\tO\nis\tO\ncapable\tO\nof\tO\ninducing\tO\nthe\tO\nrequisite\tO\nCML\tB-Disease\n-\tO\nassociated\tO\nt\tO\n(\tO\n9\tO\n:\tO\n22\tO\n)\tO\ntranslocation\tO\n(\tO\nPhiladelphia\tB-Disease\nchromosome\tI-Disease\n)\tO\nin\tO\nappropriate\tO\ncells\tO\nin\tO\nvitro\tO\nbut\tO\n,\tO\nthus\tO\nfar\tO\n,\tO\nchemicals\tO\nhave\tO\nnot\tO\nshown\tO\nthis\tO\ncapacity\tO\n.\tO\n\nWe\tO\nhave\tO\nproposed\tO\nthat\tO\n1\tB-Chemical\n,\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nbutadiene\tI-Chemical\nmetabolites\tO\nbe\tO\nso\tO\ntested\tO\nas\tO\na\tO\nreality\tO\ncheck\tO\non\tO\nthe\tO\nepidemiological\tO\nreports\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\nconduct\tO\nreliable\tO\ntesting\tO\nin\tO\nthis\tO\nregard\tO\n,\tO\nit\tO\nis\tO\nessential\tO\nthat\tO\na\tO\npositive\tO\ncontrol\tO\nfor\tO\ninduction\tO\nbe\tO\navailable\tO\n.\tO\n\nWe\tO\nhave\tO\nused\tO\nionizing\tO\nradiation\tO\nto\tO\ndevelop\tO\nsuch\tO\na\tO\ncontrol\tO\n.\tO\n\nResults\tO\ndescribed\tO\nhere\tO\ndemonstrate\tO\nthat\tO\nthis\tO\nagent\tO\ndoes\tO\nin\tO\nfact\tO\ninduce\tO\npathogenic\tO\nt\tO\n(\tO\n9\tO\n:\tO\n22\tO\n)\tO\ntranslocations\tO\nin\tO\na\tO\nhuman\tO\nmyeloid\tO\ncell\tO\nline\tO\nin\tO\nvitro\tO\n,\tO\nbut\tO\ndoes\tO\nso\tO\nat\tO\nlow\tO\nfrequencies\tO\n.\tO\n\nConditions\tO\nthat\tO\nwill\tO\nbe\tO\nrequired\tO\nfor\tO\nstudies\tO\nof\tO\n1\tB-Chemical\n,\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nbutadiene\tI-Chemical\nare\tO\ndiscussed\tO\n.\tO\n\nCancer\tB-Disease\nincidence\tO\nand\tO\nmetolachlor\tB-Chemical\nuse\tO\nin\tO\nthe\tO\nAgricultural\tO\nHealth\tO\nStudy\tO\n:\tO\nAn\tO\nupdate\tO\n.\tO\n\nUNASSIGNED\tO\n:\tO\nMetolachlor\tB-Chemical\n,\tO\na\tO\nwidely\tO\nused\tO\nherbicide\tO\n,\tO\nis\tO\nclassified\tO\nas\tO\na\tO\nGroup\tO\nC\tO\ncarcinogen\tO\nby\tO\nthe\tO\nU\tO\n.\tO\nS\tO\n.\tO\n\nEnvironmental\tO\nProtection\tO\nAgency\tO\nbased\tO\non\tO\nincreased\tO\nliver\tB-Disease\nneoplasms\tI-Disease\nin\tO\nfemale\tO\nrats\tO\n.\tO\n\nEpidemiologic\tO\nstudies\tO\nof\tO\nthe\tO\nhealth\tO\neffects\tO\nof\tO\nmetolachlor\tB-Chemical\nhave\tO\nbeen\tO\nlimited\tO\n.\tO\n\nThe\tO\nAgricultural\tO\nHealth\tO\nStudy\tO\n(\tO\nAHS\tO\n)\tO\nis\tO\na\tO\nprospective\tO\ncohort\tO\nstudy\tO\nincluding\tO\nlicensed\tO\nprivate\tO\nand\tO\ncommercial\tO\npesticide\tO\napplicators\tO\nin\tO\nIowa\tO\nand\tO\nNorth\tO\nCarolina\tO\nenrolled\tO\n1993\tO\n-\tO\n1997\tO\n.\tO\n\nWe\tO\nevaluated\tO\ncancer\tB-Disease\nincidence\tO\nthrough\tO\n2010\tO\n/\tO\n2011\tO\n(\tO\nNC\tO\n/\tO\nIA\tO\n)\tO\nfor\tO\n49\tO\n,\tO\n616\tO\napplicators\tO\n,\tO\n53\tO\n%\tO\nof\tO\nwhom\tO\nreported\tO\never\tO\nusing\tO\nmetolachlor\tB-Chemical\n.\tO\n\nWe\tO\nused\tO\nPoisson\tO\nregression\tO\nto\tO\nevaluate\tO\nrelations\tO\nbetween\tO\ntwo\tO\nmetrics\tO\nof\tO\nmetolachlor\tB-Chemical\nuse\tO\n(\tO\nlifetime\tO\ndays\tO\n,\tO\nintensity\tO\n-\tO\nweighted\tO\nlifetime\tO\ndays\tO\n)\tO\nand\tO\ncancer\tB-Disease\nincidence\tO\n.\tO\n\nWe\tO\nsaw\tO\nno\tO\nassociation\tO\nbetween\tO\nmetolachlor\tB-Chemical\nuse\tO\nand\tO\nincidence\tO\nof\tO\nall\tO\ncancers\tB-Disease\ncombined\tO\n(\tO\nn\tO\n=\tO\n5\tO\n,\tO\n701\tO\nwith\tO\na\tO\n5\tO\n-\tO\nyear\tO\nlag\tO\n)\tO\nor\tO\nmost\tO\nsite\tO\n-\tO\nspecific\tO\ncancers\tB-Disease\n.\tO\n\nFor\tO\nliver\tB-Disease\ncancer\tI-Disease\n,\tO\nin\tO\nanalyses\tO\nrestricted\tO\nto\tO\nexposed\tO\nworkers\tO\n,\tO\nelevations\tO\nobserved\tO\nat\tO\nhigher\tO\ncategories\tO\nof\tO\nuse\tO\nwere\tO\nnot\tO\nstatistically\tO\nsignificant\tO\n.\tO\n\nHowever\tO\n,\tO\ntrends\tO\nfor\tO\nboth\tO\nlifetime\tO\nand\tO\nintensity\tO\n-\tO\nweighted\tO\nlifetime\tO\ndays\tO\nof\tO\nmetolachor\tB-Chemical\nuse\tO\nwere\tO\npositive\tO\nand\tO\nstatistically\tO\nsignificant\tO\nwith\tO\nan\tO\nunexposed\tO\nreference\tO\ngroup\tO\n.\tO\n\nA\tO\nsimilar\tO\npattern\tO\nwas\tO\nobserved\tO\nfor\tO\nfollicular\tB-Disease\ncell\tI-Disease\nlymphoma\tI-Disease\n,\tO\nbut\tO\nno\tO\nother\tO\nlymphoma\tB-Disease\nsubtypes\tO\n.\tO\n\nAn\tO\nearlier\tO\nsuggestion\tO\nof\tO\nincreased\tO\nlung\tB-Disease\ncancer\tI-Disease\nrisk\tO\nat\tO\nhigh\tO\nlevels\tO\nof\tO\nmetolachlor\tB-Chemical\nuse\tO\nin\tO\nthis\tO\ncohort\tO\nwas\tO\nnot\tO\nconfirmed\tO\nin\tO\nthis\tO\nupdate\tO\n.\tO\n\nThis\tO\nsuggestion\tO\nof\tO\nan\tO\nassociation\tO\nbetween\tO\nmetolachlor\tB-Chemical\nand\tO\nliver\tB-Disease\ncancer\tI-Disease\namong\tO\npesticide\tO\napplicators\tO\nis\tO\na\tO\nnovel\tO\nfinding\tO\nand\tO\nechoes\tO\nobservation\tO\nof\tO\nincreased\tO\nliver\tB-Disease\nneoplasms\tI-Disease\nin\tO\nsome\tO\nanimal\tO\nstudies\tO\n.\tO\n\nHowever\tO\n,\tO\nour\tO\nfindings\tO\nfor\tO\nboth\tO\nliver\tB-Disease\ncancer\tI-Disease\nand\tO\nfollicular\tO\ncell\tO\nlymphoma\tB-Disease\nwarrant\tO\nfollow\tO\n-\tO\nup\tO\nto\tO\nbetter\tO\ndifferentiate\tO\neffects\tO\nof\tO\nmetolachlor\tB-Chemical\nuse\tO\nfrom\tO\nother\tO\nfactors\tO\n.\tO\n\nMechanisms\tO\nUnderlying\tO\nLatent\tO\nDisease\tO\nRisk\tO\nAssociated\tO\nwith\tO\nEarly\tO\n-\tO\nLife\tO\nArsenic\tB-Chemical\nExposure\tO\n:\tO\nCurrent\tO\nResearch\tO\nTrends\tO\nand\tO\nScientific\tO\nGaps\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nMillions\tO\nof\tO\nindividuals\tO\nworldwide\tO\n,\tO\nparticularly\tO\nthose\tO\nliving\tO\nin\tO\nrural\tO\nand\tO\ndeveloping\tO\nareas\tO\n,\tO\nare\tO\nexposed\tO\nto\tO\nharmful\tO\nlevels\tO\nof\tO\ninorganic\tB-Chemical\narsenic\tI-Chemical\n(\tO\niAs\tB-Chemical\n)\tO\nin\tO\ntheir\tO\ndrinking\tO\nwater\tO\n.\tO\n\nInorganic\tB-Chemical\nAs\tI-Chemical\nexposure\tO\nduring\tO\nkey\tO\ndevelopmental\tO\nperiods\tO\nis\tO\nassociated\tO\nwith\tO\na\tO\nvariety\tO\nof\tO\nadverse\tO\nhealth\tO\neffects\tO\nincluding\tO\nthose\tO\nthat\tO\nare\tO\nevident\tO\nin\tO\nadulthood\tO\n.\tO\n\nThere\tO\nis\tO\nconsiderable\tO\ninterest\tO\nin\tO\nidentifying\tO\nthe\tO\nmolecular\tO\nmechanisms\tO\nthat\tO\nrelate\tO\nearly\tO\n-\tO\nlife\tO\niAs\tB-Chemical\nexposure\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\nthese\tO\nlatent\tO\ndiseases\tO\n,\tO\nparticularly\tO\nin\tO\nrelationship\tO\nto\tO\ncancer\tB-Disease\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThis\tO\nwork\tO\nsummarizes\tO\nresearch\tO\non\tO\nthe\tO\nmolecular\tO\nmechanisms\tO\nthat\tO\nunderlie\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\ncancer\tB-Disease\ndevelopment\tO\nin\tO\nadulthood\tO\nthat\tO\nis\tO\nassociated\tO\nwith\tO\nearly\tO\n-\tO\nlife\tO\niAs\tB-Chemical\nexposure\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nEpigenetic\tO\nreprogramming\tO\nthat\tO\nimparts\tO\nfunctional\tO\nchanges\tO\nin\tO\ngene\tO\nexpression\tO\n,\tO\nthe\tO\ndevelopment\tO\nof\tO\ncancer\tB-Disease\nstem\tO\ncells\tO\n,\tO\nand\tO\nimmunomodulation\tO\nare\tO\nplausible\tO\nunderlying\tO\nmechanisms\tO\nby\tO\nwhich\tO\nearly\tO\n-\tO\nlife\tO\niAs\tB-Chemical\nexposure\tO\nelicits\tO\nlatent\tO\ncarcinogenic\tO\neffects\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nEvidence\tO\nis\tO\nmounting\tO\nthat\tO\nrelates\tO\nearly\tO\n-\tO\nlife\tO\niAs\tB-Chemical\nexposure\tO\nand\tO\ncancer\tB-Disease\ndevelopment\tO\nlater\tO\nin\tO\nlife\tO\n.\tO\n\nFuture\tO\nresearch\tO\nshould\tO\ninclude\tO\nanimal\tO\nstudies\tO\nthat\tO\naddress\tO\nmechanistic\tO\nhypotheses\tO\nand\tO\nstudies\tO\nof\tO\nhuman\tO\npopulations\tO\nthat\tO\nintegrate\tO\nearly\tO\n-\tO\nlife\tO\nexposure\tO\n,\tO\nmolecular\tO\nalterations\tO\n,\tO\nand\tO\nlatent\tO\ndisease\tO\noutcomes\tO\n.\tO\n\nNifedipine\tB-Chemical\ninduced\tO\nbradycardia\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nautonomic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nAn\tO\n80\tO\nyear\tO\nold\tO\ndiabetic\tB-Disease\nmale\tO\nwith\tO\nevidence\tO\nof\tO\nperipheral\tB-Disease\nand\tI-Disease\nautonomic\tI-Disease\nneuropathy\tI-Disease\nwas\tO\nadmitted\tO\nwith\tO\nchest\tB-Disease\npain\tI-Disease\n.\tO\n\nHe\tO\nwas\tO\nfound\tO\nto\tO\nhave\tO\natrial\tB-Disease\nflutter\tI-Disease\nat\tO\na\tO\nventricular\tO\nrate\tO\nof\tO\n70\tO\n/\tO\nmin\tO\nwhich\tO\nslowed\tO\ndown\tO\nto\tO\n30\tO\n-\tO\n40\tO\n/\tO\nmin\tO\nwhen\tO\nnifedipine\tB-Chemical\n(\tO\n60\tO\nmg\tO\n)\tO\nin\tO\n3\tO\ndivided\tO\ndoses\tO\n,\tO\nduring\tO\nwhich\tO\nhe\tO\nwas\tO\npaced\tO\nat\tO\na\tO\nrate\tO\nof\tO\n70\tO\n/\tO\nmin\tO\n.\tO\n\nThis\tO\nis\tO\ninconsistent\tO\nwith\tO\nthe\tO\nwell\tO\n-\tO\nestablished\tO\nfinding\tO\nthat\tO\nnifedipine\tB-Chemical\ninduces\tO\ntachycardia\tB-Disease\nin\tO\nnormally\tO\ninnervated\tO\nhearts\tO\n.\tO\n\nHowever\tO\n,\tO\nin\tO\nhearts\tO\ndeprived\tO\nof\tO\ncompensatory\tO\nsympathetic\tO\ndrive\tO\n,\tO\nit\tO\nmay\tO\nlead\tO\nto\tO\nbradycardia\tB-Disease\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nhaloperidol\tB-Chemical\nin\tO\ncocaine\tB-Chemical\nand\tO\namphetamine\tB-Chemical\nintoxication\tO\n.\tO\n\nThe\tO\neffectiveness\tO\nof\tO\nhaloperidol\tB-Chemical\npretreatment\tO\nin\tO\npreventing\tO\nthe\tO\ntoxic\tO\neffects\tO\nof\tO\nhigh\tO\ndoses\tO\nof\tO\namphetamine\tB-Chemical\nand\tO\ncocaine\tB-Chemical\nwas\tO\nstudied\tO\nin\tO\nrats\tO\n.\tO\n\nIn\tO\nthis\tO\nmodel\tO\n,\tO\ntoxic\tO\neffects\tO\nwere\tO\ninduced\tO\nby\tO\nintraperitoneal\tO\n(\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\ninjection\tO\nof\tO\namphetamine\tB-Chemical\n75\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\n100\tO\n%\tO\ndeath\tO\nrate\tO\n)\tO\nor\tO\ncocaine\tB-Chemical\n70\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\n82\tO\n%\tO\ndeath\tO\nrate\tO\n)\tO\n.\tO\n\nHaloperidol\tB-Chemical\nfailed\tO\nto\tO\nprevent\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n,\tO\nbut\tO\ndid\tO\nlower\tO\nthe\tO\nmortality\tO\nrate\tO\nat\tO\nmost\tO\ndoses\tO\ntested\tO\n.\tO\n\nHaloperidol\tB-Chemical\ndecreased\tO\nthe\tO\nincidence\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nat\tO\nthe\tO\ntwo\tO\nhighest\tO\ndoses\tO\n,\tO\nbut\tO\nthe\tO\nlowering\tO\nof\tO\nthe\tO\nmortality\tO\nrate\tO\ndid\tO\nnot\tO\nreach\tO\nstatistical\tO\nsignificance\tO\nat\tO\nany\tO\ndose\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\na\tO\nprotective\tO\nrole\tO\nfor\tO\nthe\tO\ncentral\tO\ndopamine\tB-Chemical\nblocker\tO\nhaloperidol\tB-Chemical\nagainst\tO\ndeath\tO\nfrom\tO\nhigh\tO\n-\tO\ndose\tO\namphetamine\tB-Chemical\nexposure\tO\nwithout\tO\nreducing\tO\nthe\tO\nincidence\tO\nof\tO\nseizures\tB-Disease\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nhaloperidol\tB-Chemical\ndemonstrated\tO\nan\tO\nability\tO\nto\tO\nreduce\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nwithout\tO\nsignificantly\tO\nreducing\tO\nmortality\tO\n.\tO\n\nAutoradiographic\tO\nevidence\tO\nof\tO\nestrogen\tB-Chemical\nbinding\tO\nsites\tO\nin\tO\nnuclei\tO\nof\tO\ndiethylstilbesterol\tB-Chemical\ninduced\tO\nhamster\tO\nrenal\tB-Disease\ncarcinomas\tI-Disease\n.\tO\n\nEstrogen\tB-Chemical\nbinding\tO\nsites\tO\nwere\tO\ndemonstrated\tO\nby\tO\nautoradiography\tO\nin\tO\none\tO\ntransplantable\tO\nand\tO\nfive\tO\nprimary\tO\ndiethylstilbesterol\tB-Chemical\ninduced\tO\nrenal\tB-Disease\ncarcinomas\tI-Disease\nin\tO\nthree\tO\nhamsters\tO\n.\tO\n\nRadiolabelling\tO\n,\tO\nfollowing\tO\nthe\tO\nin\tO\nvivo\tO\ninjection\tO\nof\tO\n3H\tO\n-\tO\n17\tO\nbeta\tO\nestradiol\tB-Chemical\n,\tO\nwas\tO\nincreased\tO\nonly\tO\nover\tO\nthe\tO\nnuclei\tO\nof\tO\ntumor\tB-Disease\ncells\tO\n;\tO\nstereologic\tO\nanalysis\tO\nrevealed\tO\na\tO\n4\tO\n.\tO\n5\tO\n-\tO\nto\tO\n6\tO\n.\tO\n7\tO\n-\tO\ntimes\tO\nhigher\tO\nconcentration\tO\nof\tO\nreduced\tO\nsilver\tB-Chemical\ngrains\tO\nover\tO\nnuclei\tO\nthan\tO\ncytoplasm\tO\nof\tO\nthese\tO\ncells\tO\n.\tO\n\nDespite\tO\nrapid\tO\ntubular\tO\nexcretion\tO\nof\tO\nestradiol\tB-Chemical\nwhich\tO\npeaked\tO\nin\tO\nless\tO\nthan\tO\n1\tO\nh\tO\n,\tO\nthe\tO\nnormal\tO\ncells\tO\ndid\tO\nnot\tO\nappear\tO\nto\tO\nbind\tO\nthe\tO\nligand\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\npublished\tO\nreport\tO\ndocumenting\tO\nthe\tO\npreferential\tO\nin\tO\nvivo\tO\nbinding\tO\nof\tO\nestrogen\tB-Chemical\nto\tO\nnuclei\tO\nof\tO\ncells\tO\nin\tO\nestrogen\tB-Chemical\ninduced\tO\nhamster\tO\nrenal\tB-Disease\ncarcinomas\tI-Disease\n.\tO\n\nBradycardia\tB-Disease\ndue\tO\nto\tO\nbiperiden\tB-Chemical\n.\tO\n\nIn\tO\na\tO\n38\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\npatient\tO\nsuffering\tO\nfrom\tO\na\tO\nsevere\tO\npostzosteric\tB-Disease\ntrigeminal\tB-Disease\nneuralgia\tI-Disease\n,\tO\nintravenous\tO\napplication\tO\nof\tO\n10\tO\nmg\tO\nbiperiden\tB-Chemical\nlactate\tI-Chemical\nled\tO\nto\tO\na\tO\nlong\tO\n-\tO\nlasting\tO\nparadoxical\tO\nreaction\tO\ncharacterized\tO\nby\tO\nconsiderable\tO\nbradycardia\tB-Disease\n,\tO\ndysarthria\tB-Disease\n,\tO\nand\tO\ndysphagia\tB-Disease\n.\tO\n\nThe\tO\nheart\tO\nrate\tO\nwas\tO\nback\tO\nto\tO\nnormal\tO\nwithin\tO\n12\tO\nhours\tO\nupon\tO\nadministration\tO\nof\tO\norciprenaline\tB-Chemical\nunder\tO\ncardiac\tO\nmonitoring\tO\nin\tO\nan\tO\nintensive\tO\ncare\tO\nunit\tO\n.\tO\n\nBradycardia\tB-Disease\ninduced\tO\nby\tO\nbiperiden\tB-Chemical\nis\tO\nattributed\tO\nto\tO\nthe\tO\nspeed\tO\nof\tO\ninjection\tO\nand\tO\nto\tO\na\tO\ndose\tO\n-\tO\nrelated\tO\ndual\tO\neffect\tO\nof\tO\natropine\tB-Chemical\n-\tO\nlike\tO\ndrugs\tO\non\tO\nmuscarine\tB-Chemical\nreceptors\tO\n.\tO\n\nDeliberate\tO\nhypotension\tB-Disease\ninduced\tO\nby\tO\nlabetalol\tB-Chemical\nwith\tO\nhalothane\tB-Chemical\n,\tO\nenflurane\tB-Chemical\nor\tO\nisoflurane\tB-Chemical\nfor\tO\nmiddle\tO\n-\tO\near\tO\nsurgery\tO\n.\tO\n\nThe\tO\nfeasibility\tO\nof\tO\nusing\tO\nlabetalol\tB-Chemical\n,\tO\nan\tO\nalpha\tO\n-\tO\nand\tO\nbeta\tO\n-\tO\nadrenergic\tO\nblocking\tO\nagent\tO\n,\tO\nas\tO\na\tO\nhypotensive\tB-Disease\nagent\tO\nin\tO\ncombination\tO\nwith\tO\ninhalation\tO\nanaesthetics\tO\n(\tO\nhalothane\tB-Chemical\n,\tO\nenflurane\tB-Chemical\nor\tO\nisoflurane\tB-Chemical\n)\tO\nwas\tO\nstudied\tO\nin\tO\n23\tO\nadult\tO\npatients\tO\nundergoing\tO\nmiddle\tO\n-\tO\near\tO\nsurgery\tO\n.\tO\n\nThe\tO\nmean\tO\narterial\tO\npressure\tO\nwas\tO\ndecreased\tO\nfrom\tO\n86\tO\n+\tO\n/\tO\n-\tO\n5\tO\n(\tO\ns\tO\n.\tO\ne\tO\n.\tO\nmean\tO\n)\tO\nmmHg\tO\nto\tO\n52\tO\n+\tO\n/\tO\n-\tO\n1\tO\nmmHg\tO\n(\tO\n11\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\nto\tO\n6\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nkPa\tO\n)\tO\nfor\tO\n98\tO\n+\tO\n/\tO\n-\tO\n10\tO\nmin\tO\nin\tO\nthe\tO\nhalothane\tB-Chemical\n(\tO\nH\tB-Chemical\n)\tO\ngroup\tO\n,\tO\nfrom\tO\n79\tO\n+\tO\n/\tO\n-\tO\n5\tO\nto\tO\n53\tO\n+\tO\n/\tO\n-\tO\n1\tO\nmmHg\tO\n(\tO\n10\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\nto\tO\n7\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nkPa\tO\n)\tO\nfor\tO\n129\tO\n+\tO\n/\tO\n-\tO\n11\tO\nmin\tO\nin\tO\nthe\tO\nenflurane\tB-Chemical\n(\tO\nE\tB-Chemical\n)\tO\ngroup\tO\n,\tO\nand\tO\nfrom\tO\n80\tO\n+\tO\n/\tO\n-\tO\n4\tO\nto\tO\n49\tO\n+\tO\n/\tO\n-\tO\n1\tO\nmmHg\tO\n(\tO\n10\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n5\tO\nto\tO\n6\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nkPa\tO\n)\tO\nfor\tO\n135\tO\n+\tO\n/\tO\n-\tO\n15\tO\nmin\tO\nin\tO\nthe\tO\nisoflurane\tB-Chemical\n(\tO\nI\tB-Chemical\n)\tO\ngroup\tO\n.\tO\n\nThe\tO\nmean\tO\nH\tB-Chemical\nconcentration\tO\nduring\tO\nhypotension\tB-Disease\nin\tO\nthe\tO\ninspiratory\tO\ngas\tO\nwas\tO\n0\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nvol\tO\n%\tO\n,\tO\nthe\tO\nmean\tO\nE\tB-Chemical\nconcentration\tO\n1\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nvol\tO\n%\tO\n,\tO\nand\tO\nthe\tO\nmean\tO\nI\tB-Chemical\nconcentration\tO\n1\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nvol\tO\n%\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthe\tO\npatients\tO\nreceived\tO\nfentanyl\tB-Chemical\nand\tO\nd\tB-Chemical\n-\tI-Chemical\ntubocurarine\tI-Chemical\n.\tO\n\nThe\tO\ninitial\tO\ndose\tO\nof\tO\nlabetalol\tB-Chemical\nfor\tO\nlowering\tO\nblood\tO\npressure\tO\nwas\tO\nsimilar\tO\n,\tO\n0\tO\n.\tO\n52\tO\n-\tO\n0\tO\n.\tO\n59\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nin\tO\nall\tO\nthe\tO\ngroups\tO\n.\tO\n\nDuring\tO\nhypotension\tB-Disease\n,\tO\nthe\tO\nheart\tO\nrate\tO\nwas\tO\nstable\tO\nwithout\tO\ntachy\tB-Disease\n-\tI-Disease\nor\tI-Disease\nbradycardia\tI-Disease\n.\tO\n\nThe\tO\noperating\tO\nconditions\tO\nregarding\tO\nbleeding\tB-Disease\nwere\tO\nestimated\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\nmanner\tO\n,\tO\nand\tO\ndid\tO\nnot\tO\ndiffer\tO\nsignificantly\tO\nbetween\tO\nthe\tO\ngroups\tO\n.\tO\n\nDuring\tO\nhypotension\tB-Disease\n,\tO\nthe\tO\nserum\tO\ncreatinine\tB-Chemical\nconcentration\tO\nrose\tO\nsignificantly\tO\nin\tO\nall\tO\ngroups\tO\nfrom\tO\nthe\tO\nvalues\tO\nbefore\tO\nhypotension\tB-Disease\nand\tO\nreturned\tO\npostoperatively\tO\nto\tO\nthe\tO\ninitial\tO\nlevel\tO\nin\tO\nthe\tO\nother\tO\ngroups\tO\n,\tO\nexcept\tO\nthe\tO\nisoflurane\tB-Chemical\ngroup\tO\n.\tO\n\nAfter\tO\nhypotension\tB-Disease\nthere\tO\nwas\tO\nno\tO\nrebound\tO\nphenomenon\tO\nin\tO\neither\tO\nblood\tO\npressure\tO\nor\tO\nheart\tO\nrate\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nlabetalol\tB-Chemical\ninduces\tO\neasily\tO\nadjustable\tO\nhypotension\tB-Disease\nwithout\tO\ncompensatory\tO\ntachycardia\tB-Disease\nand\tO\nrebound\tO\nhypertension\tB-Disease\n.\tO\n\nConvulsion\tB-Disease\nfollowing\tO\nintravenous\tO\nfluorescein\tB-Chemical\nangiography\tO\n.\tO\n\nTonic\tB-Disease\n-\tI-Disease\nclonic\tI-Disease\nseizures\tI-Disease\nfollowed\tO\nintravenous\tO\nfluorescein\tB-Chemical\ninjection\tO\nfor\tO\nfundus\tO\nangiography\tO\nin\tO\na\tO\n47\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\n.\tO\n\nDespite\tO\nprecautions\tO\nthis\tO\nadverse\tO\nreaction\tO\nrecurred\tO\non\tO\nre\tO\n-\tO\nexposure\tO\nto\tO\nintravenous\tO\nfluorescein\tB-Chemical\n.\tO\n\nPharmacology\tO\nof\tO\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\n(\tO\nphenytoin\tB-Chemical\nprodrug\tO\n)\tO\n.\tO\n\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\n,\tO\nthe\tO\ndisodium\tB-Chemical\nphosphate\tI-Chemical\nester\tI-Chemical\nof\tO\n3\tB-Chemical\n-\tI-Chemical\nhydroxymethyl\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\ndiphenylhydantoin\tI-Chemical\n,\tO\nis\tO\na\tO\nprodrug\tO\nof\tO\nphenytoin\tB-Chemical\nwith\tO\nadvantageous\tO\nphysicochemical\tO\nproperties\tO\n.\tO\n\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\nis\tO\nrapidly\tO\nconverted\tO\nenzymatically\tO\nto\tO\nphenytoin\tB-Chemical\nin\tO\nvivo\tO\n.\tO\n\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\nand\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\nhave\tO\nequivalent\tO\nanticonvulsant\tO\nactivity\tO\nagainst\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\nmaximal\tO\nelectroshock\tO\n(\tO\nMES\tO\n)\tO\nin\tO\nmice\tO\nfollowing\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\noral\tO\n,\tO\nor\tO\ni\tO\n.\tO\nv\tO\n.\tO\nadministration\tO\n.\tO\n\nThe\tO\nED50\tO\ndoses\tO\nwere\tO\n16\tO\nmg\tO\n/\tO\nkg\tO\nfor\tO\ni\tO\n.\tO\nv\tO\n.\tO\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\nand\tO\n8\tO\nmg\tO\n/\tO\nkg\tO\nfor\tO\ni\tO\n.\tO\nv\tO\n.\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\n.\tO\n\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\nand\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\nhave\tO\nsimilar\tO\nantiarrhythmic\tO\nactivity\tO\nagainst\tO\nouabain\tB-Chemical\n-\tO\ninduced\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nin\tO\nanesthetized\tO\ndogs\tO\n.\tO\n\nThe\tO\ntotal\tO\ndoses\tO\nof\tO\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\nor\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\nnecessary\tO\nto\tO\nconvert\tO\nthe\tO\narrhythmia\tB-Disease\nto\tO\na\tO\nnormal\tO\nsinus\tO\nrhythm\tO\nwere\tO\n24\tO\n+\tO\n/\tO\n-\tO\n6\tO\nand\tO\n14\tO\n+\tO\n/\tO\n-\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nrespectively\tO\n.\tO\n\nOnly\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\ndisplayed\tO\nin\tO\nvitro\tO\nantiarrhythmic\tO\nactivity\tO\nagainst\tO\nstrophanthidin\tB-Chemical\n-\tO\ninduced\tO\narrhythmias\tB-Disease\nin\tO\nguinea\tO\npig\tO\nright\tO\natria\tO\n.\tO\n\nIn\tO\nanesthetized\tO\ndogs\tO\n,\tO\na\tO\nhigh\tO\ndose\tO\nof\tO\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\n(\tO\n31\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ninfused\tO\nover\tO\n15\tO\n,\tO\n20\tO\n,\tO\nand\tO\n30\tO\nmin\tO\nand\tO\nthe\tO\nresponses\tO\nwere\tO\ncompared\tO\nto\tO\nan\tO\nequimolar\tO\ndose\tO\nof\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\n(\tO\n21\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nThe\tO\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\nand\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\ntreatments\tO\nproduced\tO\nsimilar\tO\nmarked\tO\nreductions\tO\nin\tO\ndiastolic\tO\nblood\tO\npressure\tO\nand\tO\ncontractile\tO\nforce\tO\n(\tO\nLVdP\tO\n/\tO\ndt\tO\n)\tO\n.\tO\n\nThe\tO\nmaximum\tO\neffects\tO\nof\tO\neach\tO\ntreatment\tO\noccurred\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\nmaximum\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\nlevels\tO\n.\tO\n\nAcute\tO\ntoxicity\tB-Disease\nstudies\tO\nof\tO\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\nand\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\nwere\tO\ncarried\tO\nout\tO\nin\tO\nmice\tO\n,\tO\nrats\tO\n,\tO\nrabbits\tO\n,\tO\nand\tO\ndogs\tO\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\n,\tO\ni\tO\n.\tO\nm\tO\n.\tO\n,\tO\nand\tO\ni\tO\n.\tO\np\tO\n.\tO\nroutes\tO\nof\tO\nadministration\tO\n.\tO\n\nThe\tO\nsystemic\tO\ntoxic\tO\nsigns\tO\nof\tO\nboth\tO\nagents\tO\nwere\tO\nsimilar\tO\nand\tO\noccurred\tO\nat\tO\napproximately\tO\nequivalent\tO\ndoses\tO\n.\tO\n\nImportantly\tO\n,\tO\nthe\tO\nlocal\tO\nirritation\tO\nof\tO\nACC\tB-Chemical\n-\tI-Chemical\n9653\tI-Chemical\nwas\tO\nmarkedly\tO\nless\tO\nthan\tO\nphenytoin\tB-Chemical\nsodium\tI-Chemical\nfollowing\tO\ni\tO\n.\tO\nm\tO\n.\tO\nadministration\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nTachyphylaxis\tO\nto\tO\nsystemic\tO\nbut\tO\nnot\tO\nto\tO\nairway\tO\nresponses\tO\nduring\tO\nprolonged\tO\ntherapy\tO\nwith\tO\nhigh\tO\ndose\tO\ninhaled\tO\nsalbutamol\tB-Chemical\nin\tO\nasthmatics\tB-Disease\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\ninhaled\tO\nsalbutamol\tB-Chemical\nproduce\tO\nsubstantial\tO\nimprovements\tO\nin\tO\nairway\tO\nresponse\tO\nin\tO\npatients\tO\nwith\tO\nasthma\tB-Disease\n,\tO\nand\tO\nare\tO\nassociated\tO\nwith\tO\ndose\tO\n-\tO\ndependent\tO\nsystemic\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\nresponses\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nwhether\tO\ntachyphylaxis\tO\noccurs\tO\nduring\tO\nprolonged\tO\ntreatment\tO\nwith\tO\nhigh\tO\ndose\tO\ninhaled\tO\nsalbutamol\tB-Chemical\n.\tO\n\nTwelve\tO\nasthmatic\tB-Disease\npatients\tO\n(\tO\nFEV1\tO\n,\tO\n81\tO\n+\tO\n/\tO\n-\tO\n4\tO\n%\tO\npredicted\tO\n)\tO\n,\tO\nrequiring\tO\nonly\tO\noccasional\tO\ninhaled\tO\nbeta\tO\n-\tO\nagonists\tO\nas\tO\ntheir\tO\nsole\tO\ntherapy\tO\n,\tO\nwere\tO\ngiven\tO\na\tO\n14\tO\n-\tO\nday\tO\ntreatment\tO\nwith\tO\nhigh\tO\ndose\tO\ninhaled\tO\nsalbutamol\tB-Chemical\n(\tO\nHDS\tO\n)\tO\n,\tO\n4\tO\n,\tO\n000\tO\nmicrograms\tO\ndaily\tO\n,\tO\nlow\tO\ndose\tO\ninhaled\tO\nsalbutamol\tB-Chemical\n(\tO\nLDS\tO\n)\tO\n,\tO\n800\tO\nmicrograms\tO\ndaily\tO\n,\tO\nor\tO\nplacebo\tO\n(\tO\nPI\tO\n)\tO\nby\tO\nmetered\tO\n-\tO\ndose\tO\ninhaler\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nrandomized\tO\ncrossover\tO\ndesign\tO\n.\tO\n\nDuring\tO\nthe\tO\n14\tO\n-\tO\nday\tO\nrun\tO\n-\tO\nin\tO\nand\tO\nduring\tO\nwashout\tO\nperiods\tO\n,\tO\ninhaled\tO\nbeta\tO\n-\tO\nagonists\tO\nwere\tO\nwithheld\tO\nand\tO\nipratropium\tB-Chemical\nbromide\tI-Chemical\nwas\tO\nsubstituted\tO\nfor\tO\nrescue\tO\npurposes\tO\n.\tO\n\nAt\tO\nthe\tO\nend\tO\nof\tO\neach\tO\n14\tO\n-\tO\nday\tO\ntreatment\tO\n,\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\ncurve\tO\n(\tO\nDRC\tO\n)\tO\nwas\tO\nperformed\tO\n,\tO\nand\tO\nairway\tO\n(\tO\nFEV1\tO\n,\tO\nFEF25\tO\n-\tO\n75\tO\n)\tO\nchronotropic\tO\n(\tO\nHR\tO\n)\tO\n,\tO\ntremor\tB-Disease\n,\tO\nand\tO\nmetabolic\tO\n(\tO\nK\tB-Chemical\n,\tO\nGlu\tB-Chemical\n)\tO\nresponses\tO\nwere\tO\nmeasured\tO\nat\tO\neach\tO\nstep\tO\n(\tO\nfrom\tO\n100\tO\nto\tO\n4\tO\n,\tO\n000\tO\nmicrograms\tO\n)\tO\n.\tO\n\nTreatment\tO\nhad\tO\nno\tO\nsignificant\tO\neffect\tO\non\tO\nbaseline\tO\nvalues\tO\n.\tO\n\nThere\tO\nwere\tO\ndose\tO\n-\tO\ndependent\tO\nincreases\tO\nin\tO\nFEV1\tO\nand\tO\nFEF25\tO\n-\tO\n75\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nand\tO\npretreatment\tO\nwith\tO\nHDS\tO\ndid\tO\nnot\tO\ndisplace\tO\nthe\tO\nDRC\tO\nto\tO\nthe\tO\nright\tO\n.\tO\n\nDRC\tO\nfor\tO\nHR\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nK\tB-Chemical\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nand\tO\nGlu\tB-Chemical\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n005\tO\n)\tO\nwere\tO\nattenuated\tO\nafter\tO\ntreatment\tO\nwith\tO\nHDS\tO\ncompared\tO\nwith\tO\nPI\tO\n.\tO\n\nThere\tO\nwere\tO\nalso\tO\ndifferences\tO\nbetween\tO\nHDS\tO\nand\tO\nLDS\tO\nfor\tO\nHR\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\nGlu\tB-Chemical\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nresponses\tO\n.\tO\n\nFrequency\tO\nand\tO\nseverity\tO\nof\tO\nsubjective\tO\nadverse\tO\neffects\tO\nwere\tO\nalso\tO\nreduced\tO\nafter\tO\nHDS\tO\n:\tO\ntremor\tB-Disease\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\npalpitations\tB-Disease\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nPhenytoin\tB-Chemical\ninduced\tO\nfatal\tO\nhepatic\tB-Disease\ninjury\tI-Disease\n.\tO\n\nA\tO\n61\tO\nyear\tO\nold\tO\nfemale\tO\ndeveloped\tO\nfatal\tO\nhepatic\tB-Disease\nfailure\tI-Disease\nafter\tO\nphenytoin\tB-Chemical\nadministration\tO\n.\tO\n\nA\tO\ntypical\tO\nmultisystem\tO\nclinical\tO\npattern\tO\nprecedes\tO\nthe\tO\nmanifestations\tO\nof\tO\nhepatic\tB-Disease\ninjury\tI-Disease\n.\tO\n\nThe\tO\nhematologic\tO\n,\tO\nbiochemical\tO\nand\tO\npathologic\tO\nfeatures\tO\nindicate\tO\na\tO\nmixed\tO\nhepatocellular\tB-Disease\ndamage\tI-Disease\ndue\tO\nto\tO\ndrug\tB-Disease\nhypersensitivity\tI-Disease\n.\tO\n\nIn\tO\na\tO\npatient\tO\nreceiving\tO\nphenytoin\tB-Chemical\nwho\tO\npresents\tO\na\tO\nviral\tO\n-\tO\nlike\tO\nillness\tO\n,\tO\nearly\tO\nrecognition\tO\nand\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nare\tO\nmandatory\tO\n.\tO\n\nTreatment\tO\nof\tO\nlethal\tO\npertussis\tB-Chemical\nvaccine\tI-Chemical\nreaction\tO\nwith\tO\nhistamine\tB-Chemical\nH1\tO\nantagonists\tO\n.\tO\n\nWe\tO\nstudied\tO\nmortality\tO\nafter\tO\npertussis\tB-Disease\nimmunization\tO\nin\tO\nthe\tO\nmouse\tO\n.\tO\n\nWithout\tO\ntreatment\tO\n,\tO\n73\tO\nof\tO\n92\tO\nanimals\tO\n(\tO\n80\tO\n%\tO\n)\tO\ndied\tO\nafter\tO\ninjection\tO\nof\tO\nbovine\tO\nserum\tO\nalbumin\tO\n(\tO\nBSA\tO\n)\tO\non\tO\nday\tO\n+\tO\n7\tO\nof\tO\npertussis\tB-Disease\nimmunization\tO\n.\tO\n\nAfter\tO\npretreatment\tO\nwith\tO\n3\tO\nmg\tO\nof\tO\ncyproheptadine\tB-Chemical\n,\tO\n2\tO\nmg\tO\nmianserin\tB-Chemical\n,\tO\nor\tO\n2\tO\nmg\tO\nchlorpheniramine\tB-Chemical\n,\tO\nonly\tO\n5\tO\nof\tO\n105\tO\nanimals\tO\n(\tO\n5\tO\n%\tO\n)\tO\ndied\tO\nafter\tO\nreceiving\tO\nBSA\tO\non\tO\nday\tO\n+\tO\n7\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nBlockade\tO\nof\tO\nhistamine\tB-Chemical\nH1\tO\nreceptors\tO\nmay\tO\nreduce\tO\nmortality\tO\nin\tO\npertussis\tB-Disease\nimmunization\tO\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nSupport\tO\nfor\tO\nadrenaline\tB-Chemical\n-\tO\nhypertension\tB-Disease\nhypothesis\tO\n:\tO\n18\tO\nhour\tO\npressor\tO\neffect\tO\nafter\tO\n6\tO\nhours\tO\nadrenaline\tB-Chemical\ninfusion\tO\n.\tO\n\nIn\tO\na\tO\ndouble\tO\nblind\tO\n,\tO\ncrossover\tO\nstudy\tO\n6\tO\nh\tO\ninfusions\tO\nof\tO\nadrenaline\tB-Chemical\n(\tO\n15\tO\nng\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n;\tO\n1\tO\nng\tO\n=\tO\n5\tO\n.\tO\n458\tO\npmol\tO\n)\tO\n,\tO\nnoradrenaline\tB-Chemical\n(\tO\n30\tO\nng\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n;\tO\n1\tO\nng\tO\n=\tO\n5\tO\n.\tO\n911\tO\npmol\tO\n)\tO\n,\tO\nand\tO\na\tO\n5\tO\n%\tO\ndextrose\tB-Chemical\nsolution\tO\n(\tO\n5\tO\n.\tO\n4\tO\nml\tO\n/\tO\nh\tO\n)\tO\n,\tO\nwere\tO\ngiven\tO\nto\tO\nten\tO\nhealthy\tO\nvolunteers\tO\nin\tO\nrandom\tO\norder\tO\n2\tO\nweeks\tO\napart\tO\n.\tO\n\nBy\tO\nmeans\tO\nof\tO\nintra\tO\n-\tO\narterial\tO\nambulatory\tO\nmonitoring\tO\nthe\tO\nhaemodynamic\tO\neffects\tO\nwere\tO\nfollowed\tO\nfor\tO\n18\tO\nh\tO\nafter\tO\nthe\tO\ninfusions\tO\nwere\tO\nstopped\tO\n.\tO\n\nAdrenaline\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nnoradrenaline\tB-Chemical\n,\tO\ncaused\tO\na\tO\ndelayed\tO\nand\tO\nprotracted\tO\npressor\tO\neffect\tO\n.\tO\n\nOver\tO\nthe\tO\ntotal\tO\npostinfusion\tO\nperiod\tO\nsystolic\tO\nand\tO\ndiastolic\tO\narterial\tO\npressure\tO\nwere\tO\n6\tO\n(\tO\nSEM\tO\n2\tO\n)\tO\n%\tO\nand\tO\n7\tO\n(\tO\n2\tO\n)\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nhigher\tO\nthan\tO\nafter\tO\ndextrose\tB-Chemical\ninfusion\tO\n(\tO\nANOVA\tO\n,\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThus\tO\n,\tO\n\"\tO\nstress\tO\n\"\tO\nlevels\tO\nof\tO\nadrenaline\tB-Chemical\n(\tO\n230\tO\npg\tO\n/\tO\nml\tO\n)\tO\nfor\tO\n6\tO\nh\tO\ncause\tO\na\tO\ndelayed\tO\nand\tO\nprotracted\tO\npressor\tO\neffect\tO\n.\tO\n\nThese\tO\nfindings\tO\nare\tO\nstrong\tO\nsupport\tO\nfor\tO\nthe\tO\nadrenaline\tB-Chemical\n-\tO\nhypertension\tB-Disease\nhypothesis\tO\nin\tO\nman\tO\n.\tO\n\nEffect\tO\nof\tO\nalkylxanthines\tB-Chemical\non\tO\ngentamicin\tB-Chemical\n-\tO\ninduced\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nAdenosine\tB-Chemical\nantagonists\tO\nhave\tO\nbeen\tO\npreviously\tO\nshown\tO\nto\tO\nbe\tO\nof\tO\nbenefit\tO\nin\tO\nsome\tO\nischaemic\tB-Disease\nand\tO\nnephrotoxic\tB-Disease\nmodels\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n(\tO\nARF\tB-Disease\n)\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthe\tO\neffects\tO\nof\tO\nthree\tO\nalkylxanthines\tB-Chemical\nwith\tO\ndifferent\tO\npotencies\tO\nas\tO\nadenosine\tB-Chemical\nantagonists\tO\n8\tB-Chemical\n-\tI-Chemical\nphenyltheophylline\tI-Chemical\n,\tO\ntheophylline\tB-Chemical\nand\tO\nenprofylline\tB-Chemical\n,\tO\nwere\tO\nexamined\tO\nin\tO\nrats\tO\ndeveloping\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nafter\tO\n4\tO\ndaily\tO\ninjections\tO\nof\tO\ngentamicin\tB-Chemical\n(\tO\n200\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nRenal\tO\nfunction\tO\nwas\tO\nassessed\tO\nby\tO\nbiochemical\tO\n(\tO\nplasma\tO\nurea\tB-Chemical\nand\tO\ncreatinine\tB-Chemical\n)\tO\n,\tO\nfunctional\tO\n(\tO\nurine\tO\nanalysis\tO\nand\tO\n[\tO\n3H\tO\n]\tO\ninulin\tO\nand\tO\n[\tO\n14C\tO\n]\tO\np\tB-Chemical\n-\tI-Chemical\naminohippuric\tI-Chemical\nacid\tI-Chemical\nclearances\tO\n)\tO\nand\tO\nmorphological\tO\n(\tO\ndegree\tO\nof\tO\nnecrosis\tB-Disease\n)\tO\nindices\tO\n.\tO\n\nThe\tO\nvarious\tO\ndrug\tO\ntreatments\tO\nproduced\tO\nimprovements\tO\nin\tO\nsome\tO\n,\tO\nbut\tO\nnot\tO\nall\tO\n,\tO\nmeasurements\tO\nof\tO\nrenal\tO\nfunction\tO\n.\tO\n\nHowever\tO\n,\tO\nany\tO\nimprovement\tO\nproduced\tO\nby\tO\ndrug\tO\ntreatment\tO\nwas\tO\nlargely\tO\na\tO\nresult\tO\nof\tO\na\tO\nbeneficial\tO\neffect\tO\nexerted\tO\nby\tO\nits\tO\nvehicle\tO\n(\tO\npolyethylene\tB-Chemical\nglycol\tI-Chemical\nand\tO\nNaOH\tB-Chemical\n)\tO\n.\tO\n\nThe\tO\nlack\tO\nof\tO\nany\tO\nconsistent\tO\nprotective\tO\neffect\tO\nnoted\tO\nwith\tO\nthe\tO\nalkylxanthines\tB-Chemical\ntested\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\nindicates\tO\nthat\tO\nadenosine\tB-Chemical\nplays\tO\nlittle\tO\n,\tO\nif\tO\nany\tO\n,\tO\npathophysiological\tO\nrole\tO\nin\tO\ngentamicin\tB-Chemical\n-\tO\ninduced\tO\nARF\tB-Disease\n.\tO\n\nAdverse\tO\nocular\tO\nreactions\tO\npossibly\tO\nassociated\tO\nwith\tO\nisotretinoin\tB-Chemical\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n261\tO\nadverse\tO\nocular\tO\nreactions\tO\noccurred\tO\nin\tO\n237\tO\npatients\tO\nwho\tO\nreceived\tO\nisotretinoin\tB-Chemical\n,\tO\na\tO\ncommonly\tO\nused\tO\ndrug\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nsevere\tO\ncystic\tO\nacne\tB-Disease\n.\tO\n\nBlepharoconjunctivitis\tB-Disease\n,\tO\nsubjective\tO\ncomplaints\tO\nof\tO\ndry\tB-Disease\neyes\tI-Disease\n,\tO\nblurred\tB-Disease\nvision\tI-Disease\n,\tO\ncontact\tO\nlens\tO\nintolerance\tO\n,\tO\nand\tO\nphotodermatitis\tB-Disease\nare\tO\nreversible\tO\nside\tO\neffects\tO\n.\tO\n\nMore\tO\nserious\tO\nocular\tO\nadverse\tO\nreactions\tO\ninclude\tO\npapilledema\tB-Disease\n,\tO\npseudotumor\tB-Disease\ncerebri\tI-Disease\n,\tO\nand\tO\nwhite\tO\nor\tO\ngray\tO\nsubepithelial\tO\ncorneal\tB-Disease\nopacities\tI-Disease\n;\tO\nall\tO\nof\tO\nthese\tO\nare\tO\nreversible\tO\nif\tO\nthe\tO\ndrug\tO\nis\tO\ndiscontinued\tO\n.\tO\n\nReported\tO\ncases\tO\nof\tO\ndecreased\tO\ndark\tO\nadaptation\tO\nare\tO\nunder\tO\ninvestigation\tO\n.\tO\n\nIsotretinoin\tB-Chemical\nis\tO\ncontraindicated\tO\nin\tO\npregnancy\tO\nbecause\tO\nof\tO\nthe\tO\nmany\tO\nreported\tO\ncongenital\tB-Disease\nabnormalities\tI-Disease\nafter\tO\nmaternal\tO\nuse\tO\n(\tO\nincluding\tO\nmicrophthalmos\tB-Disease\n,\tO\norbital\tO\nhypertelorism\tB-Disease\n,\tO\nand\tO\noptic\tB-Disease\nnerve\tI-Disease\nhypoplasia\tI-Disease\n)\tO\n.\tO\n\nProcaterol\tB-Chemical\nand\tO\nterbutaline\tB-Chemical\nin\tO\nbronchial\tB-Disease\nasthma\tI-Disease\n.\tO\n\nA\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ncross\tO\n-\tO\nover\tO\nstudy\tO\n.\tO\n\nProcaterol\tB-Chemical\n,\tO\na\tO\nnew\tO\nbeta\tO\n-\tO\n2\tO\nadrenoceptor\tO\nstimulant\tO\n,\tO\nwas\tO\nstudied\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ncross\tO\n-\tO\nover\tO\ntrial\tO\nin\tO\npatients\tO\nwith\tO\nbronchial\tB-Disease\nasthma\tI-Disease\n.\tO\n\nOral\tO\nprocaterol\tB-Chemical\n50\tO\nmicrograms\tO\nb\tO\n.\tO\nd\tO\n.\tO\n,\tO\nprocaterol\tB-Chemical\n100\tO\nmicrograms\tO\nb\tO\n.\tO\nd\tO\n.\tO\n,\tO\nand\tO\nterbutaline\tB-Chemical\n5\tO\nmg\tO\nt\tO\n.\tO\ni\tO\n.\tO\nd\tO\n.\tO\n,\tO\nwere\tO\ncompared\tO\nwhen\tO\ngiven\tO\nrandomly\tO\nin\tO\n1\tO\n-\tO\nweek\tO\ntreatment\tO\nperiods\tO\n.\tO\n\nThe\tO\nbest\tO\nclinical\tO\neffect\tO\nwas\tO\nfound\tO\nwith\tO\nterbutaline\tB-Chemical\n.\tO\n\nBoth\tO\nanti\tO\n-\tO\nasthmatic\tB-Disease\nand\tO\ntremorgenic\tB-Disease\neffects\tO\nof\tO\nprocaterol\tB-Chemical\nwere\tO\ndose\tO\n-\tO\nrelated\tO\n.\tO\n\nProcaterol\tB-Chemical\nappeared\tO\neffective\tO\nin\tO\nthe\tO\ndoses\tO\ntested\tO\n,\tO\nand\tO\na\tO\ntwice\tO\ndaily\tO\nregimen\tO\nwould\tO\nappear\tO\nto\tO\nbe\tO\nsuitable\tO\nwith\tO\nthis\tO\ndrug\tO\n.\tO\n\nSubacute\tO\neffects\tO\nof\tO\npropranolol\tB-Chemical\nand\tO\nB\tO\n24\tO\n/\tO\n76\tO\non\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nrat\tO\nheart\tB-Disease\nhypertrophy\tI-Disease\nin\tO\ncorrelation\tO\nwith\tO\nblood\tO\npressure\tO\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\npotential\tO\nbeta\tO\n-\tO\nreceptor\tO\nblocker\tO\n,\tO\nB\tO\n24\tO\n/\tO\n76\tO\ni\tO\n.\tO\ne\tO\n.\tO\n1\tO\n-\tO\n(\tO\n2\tO\n,\tO\n4\tO\n-\tO\ndichlorophenoxy\tO\n)\tO\n-\tO\n3\tO\n[\tO\n2\tO\n-\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndimethoxyphenyl\tO\n)\tO\nethanolamino\tO\n]\tO\n-\tO\nprop\tO\nan\tO\n-\tO\n2\tO\n-\tO\nol\tO\n,\tO\nwhich\tO\nis\tO\ncharacterized\tO\nby\tO\nbeta\tO\n1\tO\n-\tO\nadrenoceptor\tO\nblocking\tO\nand\tO\nbeta\tO\n2\tO\n-\tO\nadrenoceptor\tO\nstimulating\tO\nproperties\tO\nwith\tO\npropranolol\tB-Chemical\n.\tO\n\nThe\tO\nstudies\tO\nwere\tO\nperformed\tO\nusing\tO\nan\tO\nexperimental\tO\nmodel\tO\nof\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nheart\tB-Disease\nhypertrophy\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nA\tO\ncorrelation\tO\nof\tO\nthe\tO\nblood\tO\npressure\tO\nwas\tO\nneither\tO\nfound\tO\nin\tO\nthe\tO\ndevelopment\tO\nnor\tO\nin\tO\nthe\tO\nattempt\tO\nto\tO\nsuppress\tO\nthe\tO\ndevelopment\tO\nof\tO\nheart\tB-Disease\nhypertrophy\tI-Disease\nwith\tO\nthe\tO\ntwo\tO\nbeta\tO\n-\tO\nreceptor\tO\nblockers\tO\n.\tO\n\nBoth\tO\nbeta\tO\n-\tO\nblockers\tO\ninfluenced\tO\nthe\tO\ndevelopment\tO\nof\tO\nhypertrophy\tB-Disease\nto\tO\na\tO\ndifferent\tO\n,\tO\nbut\tO\nnot\tO\nreproducible\tO\nextent\tO\n.\tO\n\nIt\tO\nwas\tO\npossible\tO\nto\tO\nsuppress\tO\nthe\tO\nincreased\tO\nornithine\tB-Chemical\ndecarboxylase\tO\nactivity\tO\nwith\tO\nboth\tO\nbeta\tO\n-\tO\nblockers\tO\nin\tO\nhypertrophied\tB-Disease\nhearts\tI-Disease\n,\tO\nbut\tO\nthere\tO\nwas\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nheart\tO\nmass\tO\n.\tO\n\nNeither\tO\npropranolol\tB-Chemical\nnor\tO\nB\tO\n24\tO\n/\tO\n76\tO\ncould\tO\nstop\tO\nthe\tO\nchanges\tO\nin\tO\nthe\tO\ncharacteristic\tO\nmyosin\tO\nisoenzyme\tO\npattern\tO\nof\tO\nthe\tO\nhypertrophied\tB-Disease\nrat\tO\nheart\tO\n.\tO\n\nThus\tO\n,\tO\nthe\tO\ninvestigations\tO\ndid\tO\nnot\tO\nprovide\tO\nany\tO\nevidence\tO\nthat\tO\nthe\tO\nbeta\tO\n-\tO\nreceptor\tO\nblockers\tO\npropranolol\tB-Chemical\nand\tO\nB\tO\n24\tO\n/\tO\n76\tO\nhave\tO\nthe\tO\npotency\tO\nto\tO\nprevent\tO\nisoproterenol\tB-Chemical\nfrom\tO\nproducing\tO\nheart\tB-Disease\nhypertrophy\tI-Disease\n.\tO\n\nIncreased\tO\nanxiogenic\tO\neffects\tO\nof\tO\ncaffeine\tB-Chemical\nin\tO\npanic\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\noral\tO\nadministration\tO\nof\tO\ncaffeine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\non\tO\nbehavioral\tO\nratings\tO\n,\tO\nsomatic\tO\nsymptoms\tO\n,\tO\nblood\tO\npressure\tO\nand\tO\nplasma\tO\nlevels\tO\nof\tO\n3\tB-Chemical\n-\tI-Chemical\nmethoxy\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nhydroxyphenethyleneglycol\tI-Chemical\n(\tO\nMHPG\tB-Chemical\n)\tO\nand\tO\ncortisol\tB-Chemical\nwere\tO\ndetermined\tO\nin\tO\n17\tO\nhealthy\tO\nsubjects\tO\nand\tO\n21\tO\npatients\tO\nmeeting\tO\nDSM\tO\n-\tO\nIII\tO\ncriteria\tO\nfor\tO\nagoraphobia\tB-Disease\nwith\tO\npanic\tB-Disease\nattacks\tI-Disease\nor\tO\npanic\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nCaffeine\tB-Chemical\nproduced\tO\nsignificantly\tO\ngreater\tO\nincreases\tO\nin\tO\nsubject\tO\n-\tO\nrated\tO\nanxiety\tB-Disease\n,\tO\nnervousness\tO\n,\tO\nfear\tO\n,\tO\nnausea\tB-Disease\n,\tO\npalpitations\tB-Disease\n,\tO\nrestlessness\tB-Disease\n,\tO\nand\tO\ntremors\tB-Disease\nin\tO\nthe\tO\npatients\tO\ncompared\tO\nwith\tO\nhealthy\tO\nsubjects\tO\n.\tO\n\nIn\tO\nthe\tO\npatients\tO\n,\tO\nbut\tO\nnot\tO\nthe\tO\nhealthy\tO\nsubjects\tO\n,\tO\nthese\tO\nsymptoms\tO\nwere\tO\nsignificantly\tO\ncorrelated\tO\nwith\tO\nplasma\tO\ncaffeine\tB-Chemical\nlevels\tO\n.\tO\n\nSeventy\tO\n-\tO\none\tO\npercent\tO\nof\tO\nthe\tO\npatients\tO\nreported\tO\nthat\tO\nthe\tO\nbehavioral\tO\neffects\tO\nof\tO\ncaffeine\tB-Chemical\nwere\tO\nsimilar\tO\nto\tO\nthose\tO\nexperienced\tO\nduring\tO\npanic\tB-Disease\nattacks\tI-Disease\n.\tO\n\nCaffeine\tB-Chemical\ndid\tO\nnot\tO\nalter\tO\nplasma\tO\nMHPG\tB-Chemical\nlevels\tO\nin\tO\neither\tO\nthe\tO\nhealthy\tO\nsubjects\tO\nor\tO\npatients\tO\n.\tO\n\nCaffeine\tB-Chemical\nincreased\tO\nplasma\tO\ncortisol\tB-Chemical\nlevels\tO\nequally\tO\nin\tO\nthe\tO\npatient\tO\nand\tO\nhealthy\tO\ngroups\tO\n.\tO\n\nBecause\tO\ncaffeine\tB-Chemical\nis\tO\nan\tO\nadenosine\tB-Chemical\nreceptor\tO\nantagonist\tO\n,\tO\nthese\tO\nresults\tO\nsuggest\tO\nthat\tO\nsome\tO\npanic\tB-Disease\ndisorder\tI-Disease\npatients\tO\nmay\tO\nhave\tO\nabnormalities\tB-Disease\nin\tI-Disease\nneuronal\tI-Disease\nsystems\tI-Disease\ninvolving\tO\nadenosine\tB-Chemical\n.\tO\n\nPatients\tO\nwith\tO\nanxiety\tB-Disease\ndisorders\tI-Disease\nmay\tO\nbenefit\tO\nby\tO\navoiding\tO\ncaffeine\tB-Chemical\n-\tO\ncontaining\tO\nfoods\tO\nand\tO\nbeverages\tO\n.\tO\n\nComparison\tO\nof\tO\nthe\tO\neffect\tO\nof\tO\noxitropium\tB-Chemical\nbromide\tI-Chemical\nand\tO\nof\tO\nslow\tO\n-\tO\nrelease\tO\ntheophylline\tB-Chemical\non\tO\nnocturnal\tO\nasthma\tB-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\na\tO\nnew\tO\ninhaled\tO\nantimuscarinic\tO\ndrug\tO\n,\tO\noxitropium\tB-Chemical\nbromide\tI-Chemical\n,\tO\nand\tO\nof\tO\na\tO\nslow\tO\n-\tO\nrelease\tO\ntheophylline\tB-Chemical\npreparation\tO\nupon\tO\nnocturnal\tO\nasthma\tB-Disease\nwere\tO\ncompared\tO\nin\tO\na\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\n.\tO\n\nTwo\tO\nsamples\tO\nwere\tO\nstudied\tO\n:\tO\n12\tO\npatients\tO\nreceived\tO\noxitropium\tB-Chemical\nat\tO\n600\tO\nmicrograms\tO\n(\tO\n6\tO\nsubjects\tO\n)\tO\nor\tO\nat\tO\n400\tO\nmicrograms\tO\nt\tO\n.\tO\ni\tO\n.\tO\nd\tO\n.\tO\n\n(\tO\n6\tO\nsubjects\tO\n)\tO\nwhereas\tO\n11\tO\nreceived\tO\ntheophylline\tB-Chemical\nat\tO\n300\tO\nmg\tO\nb\tO\n.\tO\ni\tO\n.\tO\nd\tO\n.\tO\n\nMorning\tO\ndipping\tO\n,\tO\nassessed\tO\nby\tO\nthe\tO\nfall\tO\nin\tO\npeak\tO\nflow\tO\novernight\tO\n,\tO\nwas\tO\nsignificantly\tO\nreduced\tO\nin\tO\nthe\tO\nperiods\tO\nwhen\tO\neither\tO\nactive\tO\ndrug\tO\nwas\tO\ntaken\tO\n,\tO\nwhereas\tO\nno\tO\ndifference\tO\nwas\tO\nnoticed\tO\nduring\tO\nthe\tO\nplacebo\tO\nadministration\tO\n.\tO\n\nNo\tO\nsignificant\tO\ndifference\tO\nwas\tO\nnoticed\tO\nbetween\tO\nresults\tO\nobtained\tO\nwith\tO\neither\tO\nactive\tO\ndrug\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nwith\tO\neither\tO\ndosage\tO\nof\tO\noxitropium\tB-Chemical\n.\tO\n\nNo\tO\nsubject\tO\nreported\tO\nside\tO\neffects\tO\nof\tO\noxitropium\tB-Chemical\n,\tO\nas\tO\ncompared\tO\nto\tO\nthree\tO\nsubjects\tO\nreporting\tO\nnausea\tB-Disease\n,\tO\nvomiting\tB-Disease\nand\tO\ntremors\tB-Disease\nafter\tO\ntheophylline\tB-Chemical\n.\tO\n\nOxitropium\tB-Chemical\nproves\tO\nto\tO\nbe\tO\na\tO\nvaluable\tO\nalternative\tO\nto\tO\ntheophylline\tB-Chemical\nin\tO\nnocturnal\tO\nasthma\tB-Disease\n,\tO\nsince\tO\nit\tO\nis\tO\nequally\tO\npotent\tO\n,\tO\nsafer\tO\nand\tO\ndoes\tO\nnot\tO\nrequire\tO\nthe\tO\ntitration\tO\nof\tO\ndosage\tO\n.\tO\n\nPenicillin\tB-Chemical\nanaphylaxis\tB-Disease\n.\tO\n\nA\tO\ncase\tO\nof\tO\noral\tO\npenicillin\tB-Chemical\nanaphylaxis\tB-Disease\nis\tO\ndescribed\tO\n,\tO\nand\tO\nthe\tO\nterminology\tO\n,\tO\noccurrence\tO\n,\tO\nclinical\tO\nmanifestations\tO\n,\tO\npathogenesis\tO\n,\tO\nprevention\tO\n,\tO\nand\tO\ntreatment\tO\nof\tO\nanaphylaxis\tB-Disease\nare\tO\nreviewed\tO\n.\tO\n\nEmergency\tO\nphysicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\noral\tO\npenicillin\tB-Chemical\nanaphylaxis\tB-Disease\nin\tO\norder\tO\nto\tO\nprevent\tO\nits\tO\noccurrence\tO\nby\tO\nprescribing\tO\nthe\tO\nantibiotic\tO\njudiciously\tO\nand\tO\nknowledgeably\tO\nand\tO\nto\tO\noffer\tO\noptimal\tO\nmedical\tO\ntherapy\tO\nonce\tO\nthis\tO\nlife\tO\n-\tO\nthreatening\tO\nreaction\tO\nhas\tO\nbegun\tO\n.\tO\n\nReversible\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\ndementia\tB-Disease\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nReversible\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\ndementia\tB-Disease\nwas\tO\ndocumented\tO\nin\tO\na\tO\n21\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nepilepsy\tB-Disease\nwho\tO\nhad\tO\na\tO\n3\tO\n-\tO\nyear\tO\nhistory\tO\nof\tO\ninsidious\tO\nprogressive\tO\ndecline\tO\nin\tO\nglobal\tO\ncognitive\tO\nabilities\tO\ndocumented\tO\nby\tO\nserial\tO\nneuropsychological\tO\nstudies\tO\n.\tO\n\nRepeat\tO\nneuropsychological\tO\ntesting\tO\n7\tO\nweeks\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nrevealed\tO\ndramatic\tO\nimprovement\tO\nin\tO\nIQ\tO\n,\tO\nmemory\tO\n,\tO\nnaming\tO\n,\tO\nand\tO\nother\tO\ntasks\tO\ncommensurate\tO\nwith\tO\nclinical\tO\nrecovery\tO\nin\tO\nhis\tO\nintellectual\tO\ncapacity\tO\n.\tO\n\nPossible\tO\npathophysiological\tO\nmechanisms\tO\nwhich\tO\nmay\tO\nhave\tO\nbeen\tO\noperative\tO\nin\tO\nthis\tO\ncase\tO\ninclude\tO\n:\tO\na\tO\ndirect\tO\ncentral\tO\nnervous\tO\nsystem\tO\n(\tO\nCNS\tO\n)\tO\ntoxic\tO\neffect\tO\nof\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n;\tO\na\tO\nparadoxical\tO\nepileptogenic\tO\neffect\tO\nsecondary\tO\nto\tO\nthe\tO\ndrug\tO\n;\tO\nand\tO\nan\tO\nindirect\tO\nCNS\tO\ntoxic\tO\neffect\tO\nmediated\tO\nthrough\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nhyperammonemia\tB-Disease\n.\tO\n\nReversal\tO\nof\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\nof\tO\npassive\tO\navoidance\tO\nby\tO\npre\tO\n-\tO\nand\tO\npost\tO\n-\tO\ntraining\tO\nnaloxone\tB-Chemical\n.\tO\n\nIn\tO\na\tO\nseries\tO\nof\tO\nfive\tO\nexperiments\tO\n,\tO\nthe\tO\nmodulating\tO\nrole\tO\nof\tO\nnaloxone\tB-Chemical\non\tO\na\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\nretention\tB-Disease\ndeficit\tI-Disease\nin\tO\na\tO\npassive\tO\navoidance\tO\nparadigm\tO\nwas\tO\ninvestigated\tO\nin\tO\nmice\tO\n.\tO\n\nScopolamine\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nmethyl\tB-Chemical\nscopolamine\tI-Chemical\n(\tO\n1\tO\nand\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\ninduced\tO\nan\tO\namnesia\tB-Disease\nas\tO\nmeasured\tO\nby\tO\nlatency\tO\nand\tO\nduration\tO\nparameters\tO\n.\tO\n\nNaloxone\tB-Chemical\n(\tO\n0\tO\n.\tO\n3\tO\n,\tO\n1\tO\n,\tO\n3\tO\n,\tO\nand\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ninjected\tO\nprior\tO\nto\tO\ntraining\tO\nattenuated\tO\nthe\tO\nretention\tB-Disease\ndeficit\tI-Disease\nwith\tO\na\tO\npeak\tO\nof\tO\nactivity\tO\nat\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nnaloxone\tB-Chemical\ncould\tO\nbe\tO\nantagonized\tO\nwith\tO\nmorphine\tB-Chemical\n(\tO\n1\tO\n,\tO\n3\tO\n,\tO\nand\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\ndemonstrating\tO\nthe\tO\nopioid\tO\nspecificity\tO\nof\tO\nthe\tO\nnaloxone\tB-Chemical\neffect\tO\n.\tO\n\nPost\tO\n-\tO\ntraining\tO\nadministration\tO\nof\tO\nnaloxone\tB-Chemical\n(\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nas\tO\na\tO\nsingle\tO\nor\tO\nas\tO\na\tO\nsplit\tO\ndose\tO\nalso\tO\nattenuated\tO\nthe\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\n.\tO\n\nControl\tO\nexperiments\tO\nindicated\tO\nthat\tO\nneither\tO\nan\tO\nincrease\tO\nin\tO\npain\tB-Disease\nsensitivity\tO\n(\tO\npre\tO\n-\tO\ntraining\tO\nnaloxone\tB-Chemical\n)\tO\nnor\tO\nan\tO\ninduced\tO\naversive\tO\nstate\tO\n(\tO\npost\tO\n-\tO\ntraining\tO\nnaloxone\tB-Chemical\n)\tO\nappear\tO\nto\tO\nbe\tO\nresponsible\tO\nfor\tO\nthe\tO\ninfluence\tO\nof\tO\nnaloxone\tB-Chemical\non\tO\nthe\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\nretention\tB-Disease\ndeficit\tI-Disease\n.\tO\n\nThese\tO\nresults\tO\nextend\tO\nprevious\tO\nfindings\tO\nimplicating\tO\na\tO\ncholinergic\tO\n-\tO\nopioid\tO\ninteraction\tO\nin\tO\nmemory\tO\nprocesses\tO\n.\tO\n\nA\tO\npossible\tO\nmechanism\tO\nfor\tO\nthis\tO\ninteraction\tO\ninvolving\tO\nthe\tO\nsepto\tO\n-\tO\nhippocampal\tO\ncholinergic\tO\npathway\tO\nis\tO\ndiscussed\tO\n.\tO\n\nElectron\tO\nmicroscopic\tO\ninvestigations\tO\nof\tO\nthe\tO\ncyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\nlesions\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nurinary\tI-Disease\nbladder\tI-Disease\nof\tO\nthe\tO\nrat\tO\nand\tO\ntheir\tO\nprevention\tO\nby\tO\nmesna\tB-Chemical\n.\tO\n\nFully\tO\ndeveloped\tO\ncyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\nis\tO\ncharacterized\tO\nby\tO\nnearly\tO\ncomplete\tO\ndetachment\tO\nof\tO\nthe\tO\nurothelium\tO\n,\tO\nsevere\tO\nsubmucosal\tO\nedema\tB-Disease\nowing\tO\nto\tO\ndamage\tO\nto\tO\nthe\tO\nmicrovascular\tO\nbed\tO\nand\tO\nfocal\tO\nmuscle\tO\nnecroses\tB-Disease\n.\tO\n\nThe\tO\ninitial\tO\nresponse\tO\nto\tO\nthe\tO\nprimary\tO\nattack\tO\nby\tO\nthe\tO\ncyclophosphamide\tB-Chemical\nmetabolites\tO\nseems\tO\nto\tO\nbe\tO\nfragmentation\tO\nof\tO\nthe\tO\nluminal\tB-Chemical\nmembrane\tO\n.\tO\n\nThis\tO\ndamages\tO\nthe\tO\ncellular\tO\nbarrier\tO\nagainst\tO\nthe\tO\nhypertonic\tO\nurine\tO\n.\tO\n\nSubsequent\tO\nbreaks\tO\nin\tO\nthe\tO\nlateral\tO\ncell\tO\nmembranes\tO\nof\tO\nthe\tO\nsuperficial\tO\ncells\tO\nand\tO\nin\tO\nall\tO\nthe\tO\nplasma\tO\nmembranes\tO\nof\tO\nthe\tO\nintermediate\tO\nand\tO\nbasal\tO\ncells\tO\n,\tO\nintercellular\tO\nand\tO\nintracellular\tO\nedema\tB-Disease\nand\tO\ndisintegration\tO\nof\tO\nthe\tO\ndesmosomes\tO\nand\tO\nhemidesmosomes\tO\nlead\tO\nto\tO\nprogressive\tO\ndegeneration\tO\nand\tO\ndetachment\tO\nof\tO\nthe\tO\nepithelial\tO\ncells\tO\nwith\tO\nexposure\tO\nand\tO\nsplitting\tO\nof\tO\nthe\tO\nbasal\tO\nmembrane\tO\n.\tO\n\nThe\tO\nmorphological\tO\nchanges\tO\nof\tO\nthe\tO\nendothelial\tO\ncells\tO\n,\tO\nwhich\tO\nbecome\tO\nmore\tO\npronounced\tO\nin\tO\nthe\tO\nlater\tO\nstages\tO\nof\tO\nthe\tO\nexperiment\tO\n,\tO\nthe\tO\ninvolvement\tO\nof\tO\nblood\tO\nvessels\tO\nregardless\tO\nof\tO\ntheir\tO\ndiameter\tO\nand\tO\nthe\tO\nlocation\tO\n-\tO\ndependent\tO\nextent\tO\nof\tO\nthe\tO\ndamage\tO\nindicate\tO\na\tO\ndirect\tO\ntype\tO\nof\tO\ndamage\tO\nwhich\tO\nis\tO\npreceded\tO\nby\tO\na\tO\nmediator\tO\n-\tO\ninduced\tO\nincrease\tO\nin\tO\npermeability\tO\n,\tO\nthe\tO\nmorphological\tO\ncorrelate\tO\nof\tO\nwhich\tO\nis\tO\nthe\tO\nformation\tO\nof\tO\ngaps\tO\nin\tO\nthe\tO\ninterendothelial\tO\ncell\tO\nconnections\tO\non\tO\nthe\tO\nvenules\tO\n.\tO\n\nThese\tO\nchanges\tO\ncan\tO\nbe\tO\neffectively\tO\nprevented\tO\nby\tO\nmesna\tB-Chemical\n.\tO\n\nThe\tO\nonly\tO\nsign\tO\nof\tO\na\tO\npossible\tO\ninvolvement\tO\nis\tO\nthe\tO\nincrease\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nspecific\tO\ngranules\tO\nwith\tO\na\tO\npresumed\tO\nlysosomal\tO\nfunction\tO\nin\tO\nthe\tO\nsuperficial\tO\ncells\tO\n.\tO\n\nIncrease\tO\nin\tO\nintragastric\tO\npressure\tO\nduring\tO\nsuxamethonium\tB-Chemical\n-\tO\ninduced\tO\nmuscle\tB-Disease\nfasciculations\tI-Disease\nin\tO\nchildren\tO\n:\tO\ninhibition\tO\nby\tO\nalfentanil\tB-Chemical\n.\tO\n\nChanges\tO\nin\tO\nintragastric\tO\npressure\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\nsuxamethonium\tB-Chemical\n1\tO\n.\tO\n5\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\nv\tO\n.\tO\nwere\tO\nstudied\tO\nin\tO\n32\tO\nchildren\tO\n(\tO\nmean\tO\nage\tO\n6\tO\n.\tO\n9\tO\nyr\tO\n)\tO\npretreated\tO\nwith\tO\neither\tO\nphysiological\tO\nsaline\tO\nor\tO\nalfentanil\tB-Chemical\n50\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\n.\tO\n\nAnaesthesia\tO\nwas\tO\ninduced\tO\nwith\tO\nthiopentone\tB-Chemical\n5\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\n.\tO\n\nThe\tO\nincidence\tO\nand\tO\nintensity\tO\nof\tO\nmuscle\tB-Disease\nfasciculations\tI-Disease\ncaused\tO\nby\tO\nsuxamethonium\tB-Chemical\nwere\tO\nsignificantly\tO\ngreater\tO\nin\tO\nthe\tO\ncontrol\tO\nthan\tO\nin\tO\nthe\tO\nalfentanil\tB-Chemical\ngroup\tO\n.\tO\n\nThe\tO\nintragastric\tO\npressure\tO\nduring\tO\nmuscle\tB-Disease\nfasciculations\tI-Disease\nwas\tO\nsignificantly\tO\nhigher\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\n16\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\n(\tO\nSEM\tO\n)\tO\ncm\tO\nH2O\tB-Chemical\n)\tO\nthan\tO\nin\tO\nthe\tO\nalfentanil\tB-Chemical\ngroup\tO\n(\tO\n7\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n5\tO\n(\tO\nSEM\tO\n)\tO\ncm\tO\nH2O\tB-Chemical\n)\tO\n.\tO\n\nThe\tO\nincrease\tO\nin\tO\nintragastric\tO\npressure\tO\nwas\tO\ndirectly\tO\nrelated\tO\nto\tO\nthe\tO\nintensity\tO\nof\tO\nmuscle\tB-Disease\nfasciculations\tI-Disease\n(\tO\nregression\tO\nline\tO\n:\tO\ny\tO\n=\tO\n0\tO\n.\tO\n5\tO\n+\tO\n4\tO\n.\tO\n78x\tO\nwith\tO\nr\tO\nof\tO\n0\tO\n.\tO\n78\tO\n)\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nintragastric\tO\npressure\tO\nincreases\tO\nsignificantly\tO\nduring\tO\nmuscle\tB-Disease\nfasciculations\tI-Disease\ncaused\tO\nby\tO\nsuxamethonium\tB-Chemical\nin\tO\nhealthy\tO\nchildren\tO\n.\tO\n\nAlfentanil\tB-Chemical\n50\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\neffectively\tO\ninhibits\tO\nthe\tO\nincidence\tO\nand\tO\nintensity\tO\nof\tO\nsuxamethonium\tB-Chemical\n-\tO\ninduced\tO\nmuscle\tB-Disease\nfasciculations\tI-Disease\n;\tO\nmoreover\tO\n,\tO\nintragastric\tO\npressure\tO\nremains\tO\nat\tO\nits\tO\ncontrol\tO\nvalue\tO\n.\tO\n\nAcute\tO\ninsulin\tO\ntreatment\tO\nnormalizes\tO\nthe\tO\nresistance\tO\nto\tO\nthe\tO\ncardiotoxic\tB-Disease\neffect\tO\nof\tO\nisoproterenol\tB-Chemical\nin\tO\nstreptozotocin\tB-Chemical\ndiabetic\tB-Disease\nrats\tO\n.\tO\n\nA\tO\nmorphometric\tO\nstudy\tO\nof\tO\nisoproterenol\tB-Chemical\ninduced\tO\nmyocardial\tO\nfibrosis\tB-Disease\n.\tO\n\nThe\tO\nacute\tO\neffect\tO\nof\tO\ninsulin\tO\ntreatment\tO\non\tO\nthe\tO\nearlier\tO\nreported\tO\nprotective\tO\neffect\tO\nof\tO\nstreptozotocin\tB-Chemical\ndiabetes\tB-Disease\nagainst\tO\nthe\tO\ncardiotoxic\tB-Disease\neffect\tO\nof\tO\nhigh\tO\ndoses\tO\nof\tO\nisoproterenol\tB-Chemical\n(\tO\nISO\tB-Chemical\n)\tO\nwas\tO\ninvestigated\tO\nin\tO\nrats\tO\n.\tO\n\nThirty\tO\nto\tO\n135\tO\nmin\tO\nafter\tO\nthe\tO\ninjection\tO\nof\tO\ncrystalline\tO\ninsulin\tO\n,\tO\nISO\tB-Chemical\nwas\tO\ngiven\tO\nsubcutaneously\tO\nand\tO\nwhen\tO\nISO\tB-Chemical\ninduced\tO\nfibrosis\tB-Disease\nin\tO\nthe\tO\nmyocardium\tO\nwas\tO\nmorphometrically\tO\nanalyzed\tO\n7\tO\ndays\tO\nlater\tO\n,\tO\na\tO\nhighly\tO\nsignificant\tO\ncorrelation\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n83\tO\n,\tO\n2\tO\np\tO\n=\tO\n0\tO\n.\tO\n006\tO\n)\tO\nto\tO\nthe\tO\nslope\tO\nof\tO\nthe\tO\nfall\tO\nin\tO\nblood\tO\nglucose\tB-Chemical\nafter\tO\ninsulin\tO\ntreatment\tO\nappeared\tO\n.\tO\n\nThe\tO\nmyocardial\tO\ncontent\tO\nof\tO\ncatecholamines\tB-Chemical\nwas\tO\nestimated\tO\nin\tO\nthese\tO\n8\tO\nday\tO\ndiabetic\tB-Disease\nrats\tO\n.\tO\n\nThe\tO\nnorepinephrine\tB-Chemical\ncontent\tO\nwas\tO\nsignificantly\tO\nincreased\tO\nwhile\tO\nepinephrine\tB-Chemical\nremained\tO\nunchanged\tO\n.\tO\n\nAn\tO\nenhanced\tO\nsympathetic\tO\nnervous\tO\nsystem\tO\nactivity\tO\nwith\tO\na\tO\nconsequent\tO\ndown\tO\nregulation\tO\nof\tO\nthe\tO\nmyocardial\tO\nbeta\tO\n-\tO\nadrenergic\tO\nreceptors\tO\ncould\tO\n,\tO\ntherefore\tO\n,\tO\nexplain\tO\nthis\tO\ncatecholamine\tB-Chemical\nresistance\tO\n.\tO\n\nThe\tO\nrapid\tO\nreversion\tO\nafter\tO\ninsulin\tO\ntreatment\tO\nexcludes\tO\nthe\tO\npossibility\tO\nthat\tO\nstreptozotocin\tB-Chemical\nin\tO\nitself\tO\ncauses\tO\nthe\tO\nISO\tB-Chemical\nresistance\tO\nand\tO\npoints\tO\ntowards\tO\na\tO\ndirect\tO\ninsulin\tO\neffect\tO\non\tO\nmyocardial\tO\ncatecholamine\tB-Chemical\nsensitivity\tO\nin\tO\ndiabetic\tB-Disease\nrats\tO\n.\tO\n\nThe\tO\nphenomenon\tO\ndescribed\tO\nmight\tO\nelucidate\tO\npathogenetic\tO\nmechanisms\tO\nbehind\tO\ntoxic\tO\nmyocardial\tO\ncell\tO\ndegeneration\tO\nand\tO\nmay\tO\npossibly\tO\nhave\tO\nrelevance\tO\nfor\tO\nacute\tO\ncardiovascular\tO\ncomplications\tO\nin\tO\ndiabetic\tB-Disease\npatients\tO\n.\tO\n\nDifferential\tO\neffects\tO\nof\tO\nnon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\non\tO\nseizures\tB-Disease\nproduced\tO\nby\tO\npilocarpine\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nmuscarinic\tO\ncholinergic\tO\nagonist\tO\npilocarpine\tB-Chemical\ninduces\tO\nin\tO\nrats\tO\nseizures\tB-Disease\nand\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nfollowed\tO\nby\tO\nwidespread\tO\ndamage\tO\nto\tO\nthe\tO\nforebrain\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\ninvestigate\tO\nthe\tO\neffect\tO\nof\tO\n5\tO\nnon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\n,\tO\nsodium\tB-Chemical\nsalicylate\tI-Chemical\n,\tO\nphenylbutazone\tB-Chemical\n,\tO\nindomethacin\tB-Chemical\n,\tO\nibuprofen\tB-Chemical\nand\tO\nmefenamic\tB-Chemical\nacid\tI-Chemical\n,\tO\non\tO\nseizures\tB-Disease\nproduced\tO\nby\tO\npilocarpine\tB-Chemical\n.\tO\n\nPretreatment\tO\nof\tO\nrats\tO\nwith\tO\nsodium\tB-Chemical\nsalicylate\tI-Chemical\n,\tO\nED50\tO\n103\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\n60\tO\n-\tO\n174\tO\n)\tO\n,\tO\nand\tO\nphenylbutazone\tB-Chemical\n,\tO\n59\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\n50\tO\n-\tO\n70\tO\n)\tO\nconverted\tO\nthe\tO\nnon\tO\n-\tO\nconvulsant\tO\ndose\tO\nof\tO\npilocarpine\tB-Chemical\n,\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nto\tO\na\tO\nconvulsant\tO\none\tO\n.\tO\n\nIndomethacin\tB-Chemical\n,\tO\n1\tO\n-\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nand\tO\nibuprofen\tB-Chemical\n,\tO\n10\tO\n-\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nfailed\tO\nto\tO\nmodulate\tO\nseizures\tB-Disease\nproduced\tO\nby\tO\npilocarpine\tB-Chemical\n.\tO\n\nMefenamic\tB-Chemical\nacid\tI-Chemical\n,\tO\n26\tO\n(\tO\n22\tO\n-\tO\n30\tO\n)\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nprevented\tO\nseizures\tB-Disease\nand\tO\nprotected\tO\nrats\tO\nfrom\tO\nseizure\tB-Disease\n-\tO\nrelated\tO\nbrain\tB-Disease\ndamage\tI-Disease\ninduced\tO\nby\tO\npilocarpine\tB-Chemical\n,\tO\n380\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nnon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrugs\tO\ndifferentially\tO\nmodulate\tO\nthe\tO\nthreshold\tO\nfor\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nAcute\tB-Disease\nneurologic\tI-Disease\ndysfunction\tI-Disease\nafter\tO\nhigh\tO\n-\tO\ndose\tO\netoposide\tB-Chemical\ntherapy\tO\nfor\tO\nmalignant\tB-Disease\nglioma\tI-Disease\n.\tO\n\nEtoposide\tB-Chemical\n(\tO\nVP\tB-Chemical\n-\tI-Chemical\n16\tI-Chemical\n-\tI-Chemical\n213\tI-Chemical\n)\tO\nhas\tO\nbeen\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nmany\tO\nsolid\tO\ntumors\tB-Disease\nand\tO\nhematologic\tB-Disease\nmalignancies\tI-Disease\n.\tO\n\nWhen\tO\nused\tO\nin\tO\nhigh\tO\ndoses\tO\nand\tO\nin\tO\nconjunction\tO\nwith\tO\nautologous\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\n,\tO\nthis\tO\nagent\tO\nhas\tO\nactivity\tO\nagainst\tO\nseveral\tO\ntreatment\tO\n-\tO\nresistant\tO\ncancers\tB-Disease\nincluding\tO\nmalignant\tB-Disease\nglioma\tI-Disease\n.\tO\n\nIn\tO\nsix\tO\nof\tO\neight\tO\npatients\tO\n(\tO\n75\tO\n%\tO\n)\tO\nwho\tO\nwe\tO\ntreated\tO\nfor\tO\nrecurrent\tO\nor\tO\nresistant\tO\nglioma\tB-Disease\n,\tO\nsudden\tO\nsevere\tO\nneurologic\tB-Disease\ndeterioration\tI-Disease\noccurred\tO\n.\tO\n\nThis\tO\ndeveloped\tO\na\tO\nmedian\tO\nof\tO\n9\tO\ndays\tO\nafter\tO\ninitiation\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\netoposide\tB-Chemical\ntherapy\tO\n.\tO\n\nSignificant\tO\nclinical\tO\nmanifestations\tO\nhave\tO\nincluded\tO\nconfusion\tB-Disease\n,\tO\npapilledema\tB-Disease\n,\tO\nsomnolence\tB-Disease\n,\tO\nexacerbation\tO\nof\tO\nmotor\tB-Disease\ndeficits\tI-Disease\n,\tO\nand\tO\nsharp\tO\nincrease\tO\nin\tO\nseizure\tB-Disease\nactivity\tO\n.\tO\n\nThese\tO\nabnormalities\tO\nresolved\tO\nrapidly\tO\nafter\tO\ninitiation\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\nintravenous\tO\ndexamethasone\tB-Chemical\ntherapy\tO\n.\tO\n\nIn\tO\nall\tO\npatients\tO\n,\tO\ncomputerized\tO\ntomographic\tO\n(\tO\nCT\tO\n)\tO\nbrain\tO\nscans\tO\ndemonstrated\tO\nstability\tO\nin\tO\ntumor\tB-Disease\nsize\tO\nand\tO\nperitumor\tO\nedema\tB-Disease\nwhen\tO\ncompared\tO\nwith\tO\npretransplant\tO\nscans\tO\n.\tO\n\nThis\tO\ncomplication\tO\nappears\tO\nto\tO\nrepresent\tO\na\tO\nsignificant\tO\nnew\tO\ntoxicity\tB-Disease\nof\tO\nhigh\tO\n-\tO\ndose\tO\netoposide\tB-Chemical\ntherapy\tO\nfor\tO\nmalignant\tB-Disease\nglioma\tI-Disease\n.\tO\n\nProgressive\tO\nbile\tB-Disease\nduct\tI-Disease\ninjury\tI-Disease\nafter\tO\nthiabendazole\tB-Chemical\nadministration\tO\n.\tO\n\nA\tO\n27\tO\n-\tO\nyr\tO\n-\tO\nold\tO\nman\tO\ndeveloped\tO\njaundice\tB-Disease\n2\tO\nwk\tO\nafter\tO\nexposure\tO\nto\tO\nthiabendazole\tB-Chemical\n.\tO\n\nCholestasis\tB-Disease\npersisted\tO\nfor\tO\n3\tO\nyr\tO\n,\tO\nat\tO\nwhich\tO\ntime\tO\na\tO\nliver\tO\ntransplant\tO\nwas\tO\nperformed\tO\n.\tO\n\nTwo\tO\nliver\tO\nbiopsy\tO\nspecimens\tO\nand\tO\nthe\tO\nhepatectomy\tO\nspecimen\tO\nwere\tO\nremarkable\tO\nfor\tO\nalmost\tO\ncomplete\tO\ndisappearance\tO\nof\tO\ninterlobular\tO\nbile\tO\nducts\tO\n.\tO\n\nProminent\tO\nfibrosis\tB-Disease\nand\tO\nhepatocellular\tO\nregeneration\tO\nwere\tO\nalso\tO\npresent\tO\n;\tO\nhowever\tO\n,\tO\nthe\tO\nlobular\tO\narchitecture\tO\nwas\tO\npreserved\tO\n.\tO\n\nThis\tO\ncase\tO\nrepresents\tO\nan\tO\nexample\tO\nof\tO\n\"\tO\nidiosyncratic\tO\n\"\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nliver\tI-Disease\ndamage\tI-Disease\nin\tO\nwhich\tO\nthe\tO\nprimary\tO\ntarget\tO\nof\tO\ninjury\tO\nis\tO\nthe\tO\nbile\tO\nduct\tO\n.\tO\n\nAn\tO\nautoimmune\tO\npathogenesis\tO\nof\tO\nthe\tO\nbile\tB-Disease\nduct\tI-Disease\ndestruction\tI-Disease\nis\tO\nsuggested\tO\n.\tO\n\nDifferential\tO\neffects\tO\nof\tO\n1\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndihydropyridine\tI-Chemical\ncalcium\tB-Chemical\nchannel\tI-Chemical\nblockers\tI-Chemical\n:\tO\ntherapeutic\tO\nimplications\tO\n.\tO\n\nIncreasing\tO\nrecognition\tO\nof\tO\nthe\tO\nimportance\tO\nof\tO\ncalcium\tB-Chemical\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\nhas\tO\nstimulated\tO\nresearch\tO\ninto\tO\nthe\tO\nuse\tO\nof\tO\ncalcium\tB-Chemical\nchannel\tI-Chemical\nblocking\tI-Chemical\nagents\tI-Chemical\nfor\tO\ntreatment\tO\nof\tO\na\tO\nvariety\tO\nof\tO\ncardiovascular\tB-Disease\ndiseases\tI-Disease\n.\tO\n\nThe\tO\nfavorable\tO\nefficacy\tO\nand\tO\ntolerability\tO\nprofiles\tO\nof\tO\nthese\tO\nagents\tO\nmake\tO\nthem\tO\nattractive\tO\ntherapeutic\tO\nmodalities\tO\n.\tO\n\nClinical\tO\napplications\tO\nof\tO\ncalcium\tB-Chemical\nchannel\tI-Chemical\nblockers\tI-Chemical\nparallel\tO\ntheir\tO\ntissue\tO\nselectivity\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\nverapamil\tB-Chemical\nand\tO\ndiltiazem\tB-Chemical\n,\tO\nwhich\tO\nare\tO\nroughly\tO\nequipotent\tO\nin\tO\ntheir\tO\nactions\tO\non\tO\nthe\tO\nheart\tO\nand\tO\nvascular\tO\nsmooth\tO\nmuscle\tO\n,\tO\nthe\tO\ndihydropyridine\tB-Chemical\ncalcium\tB-Chemical\nchannel\tI-Chemical\nblockers\tI-Chemical\nare\tO\na\tO\ngroup\tO\nof\tO\npotent\tO\nperipheral\tO\nvasodilator\tO\nagents\tO\nthat\tO\nexert\tO\nminimal\tO\nelectrophysiologic\tO\neffects\tO\non\tO\ncardiac\tO\nnodal\tO\nor\tO\nconduction\tO\ntissue\tO\n.\tO\n\nAs\tO\nthe\tO\nfirst\tO\ndihydropyridine\tB-Chemical\navailable\tO\nfor\tO\nuse\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n,\tO\nnifedipine\tB-Chemical\ncontrols\tO\nangina\tB-Disease\nand\tO\nhypertension\tB-Disease\nwith\tO\nminimal\tO\ndepression\tO\nof\tO\ncardiac\tO\nfunction\tO\n.\tO\n\nAdditional\tO\nmembers\tO\nof\tO\nthis\tO\ngroup\tO\nof\tO\ncalcium\tB-Chemical\nchannel\tI-Chemical\nblockers\tI-Chemical\nhave\tO\nbeen\tO\nstudied\tO\nfor\tO\na\tO\nvariety\tO\nof\tO\nindications\tO\nfor\tO\nwhich\tO\nthey\tO\nmay\tO\noffer\tO\nadvantages\tO\nover\tO\ncurrent\tO\ntherapy\tO\n.\tO\n\nOnce\tO\nor\tO\ntwice\tO\ndaily\tO\ndosage\tO\npossible\tO\nwith\tO\nnitrendipine\tB-Chemical\nand\tO\nnisoldipine\tB-Chemical\noffers\tO\na\tO\nconvenient\tO\nadministration\tO\nschedule\tO\n,\tO\nwhich\tO\nencourages\tO\npatient\tO\ncompliance\tO\nin\tO\nlong\tO\n-\tO\nterm\tO\ntherapy\tO\nof\tO\nhypertension\tB-Disease\n.\tO\n\nThe\tO\ncoronary\tO\nvasodilating\tO\nproperties\tO\nof\tO\nnisoldipine\tB-Chemical\nhave\tO\nled\tO\nto\tO\nthe\tO\ninvestigation\tO\nof\tO\nthis\tO\nagent\tO\nfor\tO\nuse\tO\nin\tO\nangina\tB-Disease\n.\tO\n\nSelectivity\tO\nfor\tO\nthe\tO\ncerebrovascular\tO\nbed\tO\nmakes\tO\nnimodipine\tB-Chemical\npotentially\tO\nuseful\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\n,\tO\nmigraine\tB-Disease\nheadache\tI-Disease\n,\tO\ndementia\tB-Disease\n,\tO\nand\tO\nstroke\tB-Disease\n.\tO\n\nIn\tO\ngeneral\tO\n,\tO\nthe\tO\ndihydropyridine\tB-Chemical\ncalcium\tB-Chemical\nchannel\tI-Chemical\nblockers\tI-Chemical\nare\tO\nusually\tO\nwell\tO\ntolerated\tO\n,\tO\nwith\tO\nheadache\tB-Disease\n,\tO\nfacial\tO\nflushing\tB-Disease\n,\tO\npalpitations\tB-Disease\n,\tO\nedema\tB-Disease\n,\tO\nnausea\tB-Disease\n,\tO\nanorexia\tB-Disease\n,\tO\nand\tO\ndizziness\tB-Disease\nbeing\tO\nthe\tO\nmore\tO\ncommon\tO\nadverse\tO\neffects\tO\n.\tO\n\nThe\tO\nenhancement\tO\nof\tO\naminonucleoside\tB-Chemical\nnephrosis\tB-Disease\nby\tO\nthe\tO\nco\tO\n-\tO\nadministration\tO\nof\tO\nprotamine\tO\n.\tO\n\nAn\tO\nexperimental\tO\nmodel\tO\nof\tO\nfocal\tB-Disease\nsegmental\tI-Disease\nglomerular\tI-Disease\nsclerosis\tI-Disease\n(\tO\nFSGS\tB-Disease\n)\tO\nwas\tO\ndeveloped\tO\nin\tO\nrats\tO\nby\tO\nthe\tO\ncombined\tO\nadministration\tO\nof\tO\npuromycin\tB-Chemical\n-\tI-Chemical\naminonucleoside\tI-Chemical\n(\tO\nAMNS\tB-Chemical\n)\tO\nand\tO\nprotamine\tB-Chemical\nsulfate\tI-Chemical\n(\tO\nPS\tB-Chemical\n)\tO\n.\tO\n\nMale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\n,\tO\nuninephrectomized\tO\nthree\tO\nweeks\tO\nbefore\tO\n,\tO\nreceived\tO\ndaily\tO\ninjections\tO\nof\tO\nsubcutaneous\tO\nAMNS\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\n100\tO\ng\tO\nbody\tO\nwt\tO\n)\tO\nand\tO\nintravenous\tO\nPS\tB-Chemical\n(\tO\n2\tO\nseparated\tO\ndoses\tO\nof\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\n100\tO\ng\tO\nbody\tO\nwt\tO\n)\tO\nfor\tO\nfour\tO\ndays\tO\n.\tO\n\nThe\tO\nseries\tO\nof\tO\ninjections\tO\nwere\tO\nrepeated\tO\nanother\tO\nthree\tO\ntimes\tO\nat\tO\n10\tO\nday\tO\nintervals\tO\n.\tO\n\nThe\tO\nanimals\tO\nwere\tO\nsacrificed\tO\non\tO\ndays\tO\n24\tO\n,\tO\n52\tO\n,\tO\nand\tO\n80\tO\n.\tO\n\nThey\tO\ndeveloped\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\nand\tO\nfinally\tO\nrenal\tB-Disease\nfailure\tI-Disease\n.\tO\n\nThe\tO\ntime\tO\n-\tO\ncourse\tO\ncurve\tO\nof\tO\ncreatinine\tB-Chemical\nclearance\tO\ndropped\tO\nand\tO\nshowed\tO\nsignificant\tO\ndifference\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\nfrom\tO\nthat\tO\nof\tO\neach\tO\ncontrol\tO\ngroup\tO\n,\tO\nsuch\tO\nas\tO\n,\tO\nAMNS\tB-Chemical\nalone\tO\n,\tO\nPS\tB-Chemical\nalone\tO\nor\tO\nsaline\tO\ninjected\tO\n.\tO\n\nTheir\tO\nglomeruli\tO\nshowed\tO\nchanges\tO\nof\tO\nprogressive\tO\nFSGS\tB-Disease\n.\tO\n\nThe\tO\nultrastructural\tO\nstudies\tO\nin\tO\nthe\tO\ninitial\tO\nstage\tO\nrevealed\tO\nsignificant\tO\nlack\tO\nof\tO\nparticles\tO\nof\tO\nperfused\tO\nruthenium\tB-Chemical\nred\tO\non\tO\nthe\tO\nlamina\tO\nrara\tO\nexterna\tO\nand\tO\nmarked\tO\nchanges\tO\nin\tO\nepithelial\tO\ncell\tO\ncytoplasm\tO\n.\tO\n\nTherefore\tO\n,\tO\nit\tO\nis\tO\nsuggested\tO\nthat\tO\nthe\tO\nadministration\tO\nof\tO\nPS\tB-Chemical\nenhances\tO\nthe\tO\ntoxicity\tB-Disease\nof\tO\nAMNS\tB-Chemical\non\tO\nthe\tO\nglomerulus\tO\nand\tO\nreadily\tO\nproduces\tO\nprogressive\tO\nFSGS\tB-Disease\nin\tO\nrats\tO\nresulting\tO\nin\tO\nthe\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n.\tO\n\nTheophylline\tB-Chemical\nneurotoxicity\tB-Disease\nin\tO\npregnant\tO\nrats\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\ninvestigation\tO\nwas\tO\nto\tO\ndetermine\tO\nwhether\tO\nthe\tO\nneurotoxicity\tB-Disease\nof\tO\ntheophylline\tB-Chemical\nis\tO\naltered\tO\nin\tO\nadvanced\tO\npregnancy\tO\n.\tO\n\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nthat\tO\nwere\tO\n20\tO\ndays\tO\npregnant\tO\nand\tO\nnonpregnant\tO\nrats\tO\nof\tO\nthe\tO\nsame\tO\nage\tO\nand\tO\nstrain\tO\nreceived\tO\ninfusions\tO\nof\tO\naminophylline\tB-Chemical\nuntil\tO\nonset\tO\nof\tO\nmaximal\tO\nseizures\tB-Disease\nwhich\tO\noccurred\tO\nafter\tO\n28\tO\nand\tO\n30\tO\nminutes\tO\nrespectively\tO\n.\tO\n\nTheophylline\tB-Chemical\nconcentrations\tO\nat\tO\nthis\tO\nendpoint\tO\nin\tO\nserum\tO\n(\tO\ntotal\tO\n)\tO\nand\tO\nCSF\tO\nwere\tO\nsimilar\tO\nbut\tO\nserum\tO\n(\tO\nfree\tO\n)\tO\nand\tO\nbrain\tO\nconcentrations\tO\nwere\tO\nslightly\tO\ndifferent\tO\nin\tO\npregnant\tO\nrats\tO\n.\tO\n\nTheophylline\tB-Chemical\nserum\tO\nprotein\tO\nbinding\tO\ndetermined\tO\nby\tO\nequilibrium\tO\ndialysis\tO\nwas\tO\nlower\tO\nin\tO\npregnant\tO\nrats\tO\n.\tO\n\nFetal\tO\nserum\tO\nconcentrations\tO\nat\tO\nonset\tO\nof\tO\nseizures\tB-Disease\nin\tO\nthe\tO\nmother\tO\nwere\tO\nsimilar\tO\nto\tO\nmaternal\tO\nbrain\tO\nand\tO\nCSF\tO\nconcentrations\tO\nand\tO\ncorrelated\tO\nsignificantly\tO\nwith\tO\nthe\tO\nformer\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nadvanced\tO\npregnancy\tO\nhas\tO\na\tO\nnegligible\tO\neffect\tO\non\tO\nthe\tO\nneurotoxic\tB-Disease\nresponse\tO\nto\tO\ntheophylline\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nHyperkalemia\tB-Disease\ninduced\tO\nby\tO\nindomethacin\tB-Chemical\nand\tO\nnaproxen\tB-Chemical\nand\tO\nreversed\tO\nby\tO\nfludrocortisone\tB-Chemical\n.\tO\n\nWe\tO\nhave\tO\ndescribed\tO\na\tO\npatient\tO\nwith\tO\nsevere\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\nand\tO\na\tO\nhistory\tO\nof\tO\nmefenamic\tB-Chemical\nacid\tI-Chemical\nnephropathy\tB-Disease\nin\tO\nwhom\tO\nhyperkalemia\tB-Disease\nand\tO\ninappropriate\tO\nhypoaldosteronism\tB-Disease\nwere\tO\ncaused\tO\nby\tO\nboth\tO\nindomethacin\tB-Chemical\nand\tO\nnaproxen\tB-Chemical\n,\tO\nwithout\tO\nmajor\tO\ndecline\tO\nin\tO\nrenal\tO\nfunction\tO\n.\tO\n\nIt\tO\nis\tO\nlikely\tO\nthat\tO\npreexisting\tO\nrenal\tB-Disease\ndisease\tI-Disease\npredisposed\tO\nthis\tO\npatient\tO\nto\tO\ntype\tB-Disease\nIV\tI-Disease\nrenal\tI-Disease\ntubular\tI-Disease\nacidosis\tI-Disease\nwith\tO\nprostaglandin\tB-Chemical\nsynthetase\tO\ninhibitors\tO\n.\tO\n\nBecause\tO\nhe\tO\nwas\tO\nunable\tO\nto\tO\ndiscontinue\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ndrug\tO\ntherapy\tO\n,\tO\nfludrocortisone\tB-Chemical\nwas\tO\nadded\tO\n,\tO\ncorrecting\tO\nthe\tO\nhyperkalemia\tB-Disease\nand\tO\nallowing\tO\nindomethacin\tB-Chemical\ntherapy\tO\nto\tO\nbe\tO\ncontinued\tO\nsafely\tO\n.\tO\n\nHypotension\tB-Disease\nas\tO\na\tO\nmanifestation\tO\nof\tO\ncardiotoxicity\tB-Disease\nin\tO\nthree\tO\npatients\tO\nreceiving\tO\ncisplatin\tB-Chemical\nand\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n.\tO\n\nCardiac\tO\nsymptoms\tO\n,\tO\nincluding\tO\nhypotension\tB-Disease\n,\tO\ndeveloped\tO\nin\tO\nthree\tO\npatients\tO\nwith\tO\nadvanced\tO\ncolorectal\tB-Disease\ncarcinoma\tI-Disease\nwhile\tO\nbeing\tO\ntreated\tO\nwith\tO\ncisplatin\tB-Chemical\n(\tO\nCDDP\tB-Chemical\n)\tO\nand\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\n.\tO\n\nIn\tO\ntwo\tO\npatients\tO\n,\tO\nhypotension\tB-Disease\nwas\tO\nassociated\tO\nwith\tO\nsevere\tO\nleft\tB-Disease\nventricular\tI-Disease\ndysfunction\tI-Disease\n.\tO\n\nAll\tO\nthree\tO\npatients\tO\nrequired\tO\ntherapy\tO\ndiscontinuation\tO\n.\tO\n\nCardiac\tO\nenzymes\tO\nremained\tO\nnormal\tO\ndespite\tO\ntransient\tO\nelectrocardiographic\tO\n(\tO\nEKG\tO\n)\tO\nchanges\tO\n.\tO\n\nThe\tO\npresentation\tO\nand\tO\ncardiac\tO\nevaluation\tO\n(\tO\nhemodynamic\tO\n,\tO\nechocardiographic\tO\n,\tO\nand\tO\nscintigraphic\tO\n)\tO\nof\tO\nthese\tO\npatients\tO\nsuggest\tO\nnew\tO\nmanifestations\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ncardiotoxicity\tB-Disease\nthat\tO\nmay\tO\nbe\tO\ninfluenced\tO\nby\tO\nCDDP\tB-Chemical\n.\tO\n\nThe\tO\npossible\tO\npathophysiologic\tO\nmechanisms\tO\nare\tO\ndiscussed\tO\n.\tO\n\nFatal\tO\naplastic\tB-Disease\nanemia\tI-Disease\nin\tO\na\tO\npatient\tO\ntreated\tO\nwith\tO\ncarbamazepine\tB-Chemical\n.\tO\n\nA\tO\ncase\tO\nof\tO\nfatal\tO\naplastic\tB-Disease\nanemia\tI-Disease\ndue\tO\nto\tO\ncarbamazepine\tB-Chemical\ntreatment\tO\nin\tO\nan\tO\nepileptic\tB-Disease\nwoman\tO\nis\tO\nreported\tO\n.\tO\n\nDespite\tO\nconcerns\tO\nof\tO\nfatal\tO\nbone\tB-Disease\nmarrow\tI-Disease\ntoxicity\tI-Disease\ndue\tO\nto\tO\ncarbamazepine\tB-Chemical\n,\tO\nthis\tO\nis\tO\nonly\tO\nthe\tO\nfourth\tO\ndocumented\tO\nand\tO\npublished\tO\nreport\tO\n.\tO\n\nCarbamazepine\tB-Chemical\nis\tO\na\tO\nsafe\tO\ndrug\tO\n,\tO\nbut\tO\nphysicians\tO\nand\tO\npatients\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthe\tO\nexceedingly\tO\nrare\tO\nbut\tO\npotentially\tO\nfatal\tO\nside\tO\neffects\tO\n,\tO\nbetter\tO\nprevented\tO\nby\tO\nclinical\tO\nthan\tO\nby\tO\nlaboratory\tO\nmonitoring\tO\n.\tO\n\nParticipation\tO\nof\tO\na\tO\nbulbospinal\tO\nserotonergic\tO\npathway\tO\nin\tO\nthe\tO\nrat\tO\nbrain\tO\nin\tO\nclonidine\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nand\tO\nbradycardia\tB-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nmicroinjection\tO\nof\tO\nclonidine\tB-Chemical\n(\tO\n1\tO\n-\tO\n10\tO\nmicrograms\tO\nin\tO\n1\tO\nmicroliter\tO\n)\tO\ninto\tO\na\tO\nregion\tO\nadjacent\tO\nto\tO\nthe\tO\nventrolateral\tO\nsurface\tO\nof\tO\nthe\tO\nmedulla\tO\noblongata\tO\non\tO\ncardiovascular\tO\nfunction\tO\nwere\tO\nassessed\tO\nin\tO\nurethane\tB-Chemical\n-\tO\nanesthetized\tO\nrats\tO\n.\tO\n\nIntramedullary\tO\nadministration\tO\nof\tO\nclonidine\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nsaline\tO\nvehicle\tO\n,\tO\ncaused\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\ndecrease\tO\nin\tO\nboth\tO\nthe\tO\nmean\tO\narterial\tO\npressure\tO\nand\tO\nthe\tO\nheart\tO\nrate\tO\n.\tO\n\nThe\tO\nclonidine\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nwas\tO\nantagonized\tO\nby\tO\nprior\tO\nspinal\tO\ntransection\tO\n,\tO\nbut\tO\nnot\tO\nbilateral\tO\nvagotomy\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nthe\tO\nclonidine\tB-Chemical\n-\tO\ninduced\tO\nbradycardia\tB-Disease\nwas\tO\nantagonized\tO\nby\tO\nprior\tO\nbilateral\tO\nvagotomy\tO\n,\tO\nbut\tO\nnot\tO\nspinal\tO\ntransection\tO\n.\tO\n\nFurthermore\tO\n,\tO\nselective\tO\ndestruction\tO\nof\tO\nthe\tO\nspinal\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\nnerves\tO\n,\tO\nproduced\tO\nby\tO\nbilateral\tO\nspinal\tO\ninjection\tO\nof\tO\n5\tB-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\ndihydroxytryptamine\tI-Chemical\n,\tO\nreduced\tO\nthe\tO\nmagnitude\tO\nof\tO\nthe\tO\nvasodepressor\tO\nor\tO\nthe\tO\nbradycardiac\tB-Disease\nresponses\tO\nto\tO\nclonidine\tB-Chemical\nmicroinjected\tO\ninto\tO\nthe\tO\narea\tO\nnear\tO\nthe\tO\nventrolateral\tO\nsurface\tO\nof\tO\nthe\tO\nmedulla\tO\noblongata\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\ndata\tO\nindicate\tO\nthat\tO\na\tO\nbulbospinal\tO\nserotonergic\tO\npathway\tO\nis\tO\ninvolved\tO\nin\tO\ndevelopment\tO\nof\tO\nclonidine\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nand\tO\nbradycardia\tB-Disease\n.\tO\n\nThe\tO\ninduced\tO\nhypotension\tB-Disease\nis\tO\nbrought\tO\nabout\tO\nby\tO\na\tO\ndecrease\tO\nin\tO\nsympathetic\tO\nefferent\tO\nactivity\tO\n,\tO\nwhereas\tO\nthe\tO\ninduced\tO\nbradycardia\tB-Disease\nwas\tO\ndue\tO\nto\tO\nan\tO\nincrease\tO\nin\tO\nvagal\tO\nefferent\tO\nactivity\tO\n.\tO\n\nHypertension\tB-Disease\nin\tO\nneuroblastoma\tB-Disease\ninduced\tO\nby\tO\nimipramine\tB-Chemical\n.\tO\n\nHypertension\tB-Disease\nis\tO\na\tO\nwell\tO\n-\tO\nknown\tO\nfinding\tO\nin\tO\nsome\tO\npatients\tO\nwith\tO\nneuroblastoma\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nit\tO\nhas\tO\nnot\tO\npreviously\tO\nbeen\tO\ndescribed\tO\nin\tO\nassociation\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nImipramine\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\noccurrence\tO\nof\tO\nsevere\tO\nhypertension\tB-Disease\n(\tO\nblood\tO\npressure\tO\n190\tO\n/\tO\n160\tO\n)\tO\nin\tO\na\tO\n4\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ngirl\tO\nwith\tO\nneuroblastoma\tB-Disease\nwho\tO\nwas\tO\ngiven\tO\nImipramine\tB-Chemical\nto\tO\ncontrol\tO\na\tO\nbehavior\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nIt\tO\nwas\tO\ndetermined\tO\nlater\tO\nthat\tO\nthis\tO\npatient\tO\n'\tO\ns\tO\ntumor\tB-Disease\nwas\tO\nrecurring\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\nher\tO\nhypertensive\tB-Disease\nepisode\tO\n.\tO\n\nSince\tO\nshe\tO\nhad\tO\nno\tO\nblood\tO\npressure\tO\nelevation\tO\nat\tO\ninitial\tO\ndiagnosis\tO\nand\tO\nnone\tO\nfollowing\tO\ndiscontinuation\tO\nof\tO\nthe\tO\nImipramine\tB-Chemical\n(\tO\nwhen\tO\nshe\tO\nwas\tO\nin\tO\nflorid\tO\nrelapse\tO\n)\tO\n,\tO\nwe\tO\nbelieve\tO\nthat\tO\nthis\tO\ndrug\tO\nrather\tO\nthan\tO\nher\tO\nunderlying\tO\ndisease\tO\nalone\tO\ncaused\tO\nher\tO\nhypertension\tB-Disease\n.\tO\n\nThe\tO\nmechanism\tO\nfor\tO\nthis\tO\nreaction\tO\nis\tO\nbelieved\tO\nto\tO\nbe\tO\nincreased\tO\nlevels\tO\nof\tO\nvasoactive\tO\ncatecholamines\tB-Chemical\ndue\tO\nto\tO\ninterference\tO\nof\tO\ntheir\tO\nphysiologic\tO\ninactivation\tO\nby\tO\nImipramine\tB-Chemical\n.\tO\n\nFrom\tO\nthis\tO\nexperience\tO\n,\tO\nwe\tO\nurge\tO\nextreme\tO\ncaution\tO\nin\tO\nthe\tO\nuse\tO\nof\tO\ntricyclic\tO\nantidepressants\tO\nin\tO\nchildren\tO\nwith\tO\nactive\tO\nneuroblastoma\tB-Disease\n.\tO\n\nRechallenge\tO\nof\tO\npatients\tO\nwho\tO\ndeveloped\tO\noral\tB-Disease\ncandidiasis\tI-Disease\nor\tO\nhoarseness\tB-Disease\nwith\tO\nbeclomethasone\tB-Chemical\ndipropionate\tI-Chemical\n.\tO\n\nOf\tO\n158\tO\nasthmatic\tB-Disease\npatients\tO\nwho\tO\nwere\tO\nplaced\tO\non\tO\ninhaled\tO\nbeclomethasone\tB-Chemical\n,\tO\n15\tO\n(\tO\n9\tO\n.\tO\n5\tO\n%\tO\n)\tO\ndeveloped\tO\neither\tO\nhoarseness\tB-Disease\n(\tO\n8\tO\n)\tO\n,\tO\noral\tO\nthrush\tB-Disease\n(\tO\n6\tO\n)\tO\n,\tO\nor\tO\nboth\tO\n(\tO\n1\tO\n)\tO\n.\tO\n\nWhen\tO\ntheir\tO\nadverse\tO\nreactions\tO\nsubsided\tO\n,\tO\nseven\tO\nof\tO\nthese\tO\n15\tO\npatients\tO\nwere\tO\nrechallenged\tO\nwith\tO\ninhaled\tO\nbeclomethasone\tB-Chemical\n.\tO\n\nThese\tO\nincluded\tO\nfive\tO\ncases\tO\nwho\tO\ndeveloped\tO\nhoarseness\tB-Disease\nand\tO\nthree\tO\nwho\tO\ndeveloped\tO\nCandidiasis\tB-Disease\n.\tO\n\nOne\tO\npatient\tO\nhad\tO\nboth\tO\n.\tO\n\nOral\tO\nthrush\tB-Disease\ndid\tO\nnot\tO\nrecur\tO\n,\tO\nbut\tO\n60\tO\n%\tO\n(\tO\n3\tO\n/\tO\n5\tO\n)\tO\nof\tO\npatients\tO\nwith\tO\nhoarseness\tB-Disease\nhad\tO\nrecurrence\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\npatients\tO\nmay\tO\nbe\tO\nrestarted\tO\non\tO\ninhaled\tO\nbeclomethasone\tB-Chemical\nwhen\tO\nclinically\tO\nindicated\tO\n;\tO\nhowever\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nhigh\tO\nrecurrence\tO\nrate\tO\n,\tO\npatients\tO\nwho\tO\ndevelop\tO\nhoarseness\tB-Disease\nshould\tO\nnot\tO\nbe\tO\nre\tO\n-\tO\nchallenged\tO\n.\tO\n\nConcomitant\tO\nuse\tO\nof\tO\noral\tO\nprednisone\tB-Chemical\nand\tO\ntopical\tO\nbeclomethasone\tB-Chemical\nmay\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\ndeveloping\tO\nhoarseness\tB-Disease\nor\tO\ncandidiasis\tB-Disease\n.\tO\n\nCyclophosphamide\tB-Chemical\ncardiotoxicity\tB-Disease\n:\tO\nan\tO\nanalysis\tO\nof\tO\ndosing\tO\nas\tO\na\tO\nrisk\tO\nfactor\tO\n.\tO\n\nPatients\tO\nwho\tO\nundergo\tO\nbone\tO\nmarrow\tO\ntransplantation\tO\nare\tO\ngenerally\tO\nimmunosuppressed\tO\nwith\tO\na\tO\ndose\tO\nof\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCYA\tB-Chemical\n)\tO\nwhich\tO\nis\tO\nusually\tO\ncalculated\tO\nbased\tO\non\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nweight\tO\n.\tO\n\nAt\tO\nthese\tO\nhigh\tO\ndoses\tO\nof\tO\nCYA\tB-Chemical\n,\tO\nserious\tO\ncardiotoxicity\tB-Disease\nmay\tO\noccur\tO\n,\tO\nbut\tO\ndefinitive\tO\nrisk\tO\nfactors\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nsuch\tO\ncardiotoxicity\tB-Disease\nhave\tO\nnot\tO\nbeen\tO\ndescribed\tO\n.\tO\n\nSince\tO\nchemotherapeutic\tO\nagent\tO\ntoxicity\tB-Disease\ngenerally\tO\ncorrelates\tO\nwith\tO\ndose\tO\nper\tO\nbody\tO\nsurface\tO\narea\tO\n,\tO\nwe\tO\nretrospectively\tO\ncalculated\tO\nthe\tO\ndose\tO\nof\tO\nCYA\tB-Chemical\nin\tO\npatients\tO\ntransplanted\tO\nat\tO\nour\tO\ninstitution\tO\nto\tO\ndetermine\tO\nwhether\tO\nthe\tO\nincidence\tO\nof\tO\nCYA\tB-Chemical\ncardiotoxicity\tB-Disease\ncorrelated\tO\nwith\tO\nthe\tO\ndose\tO\nper\tO\nbody\tO\nsurface\tO\narea\tO\n.\tO\n\nEighty\tO\npatients\tO\nwho\tO\nwere\tO\nto\tO\nreceive\tO\nCYA\tB-Chemical\n50\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nd\tO\nfor\tO\nfour\tO\ndays\tO\nas\tO\npreparation\tO\nfor\tO\nmarrow\tO\ngrafting\tO\nunderwent\tO\na\tO\ntotal\tO\nof\tO\n84\tO\ntransplants\tO\nfor\tO\naplastic\tB-Disease\nanemia\tI-Disease\n,\tO\nWiskott\tB-Disease\n-\tI-Disease\nAldrich\tI-Disease\nsyndrome\tI-Disease\n,\tO\nor\tO\nsevere\tB-Disease\ncombined\tI-Disease\nimmunodeficiency\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nFourteen\tO\nof\tO\n84\tO\n(\tO\n17\tO\n%\tO\n)\tO\npatients\tO\nhad\tO\nsymptoms\tO\nand\tO\nsigns\tO\nconsistent\tO\nwith\tO\nCYA\tB-Chemical\ncardiotoxicity\tB-Disease\nwithin\tO\nten\tO\ndays\tO\nof\tO\nreceiving\tO\n1\tO\nto\tO\n4\tO\ndoses\tO\nof\tO\nCYA\tB-Chemical\n.\tO\n\nSix\tO\nof\tO\nthe\tO\n14\tO\npatients\tO\ndied\tO\nwith\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n.\tO\n\nThe\tO\ndose\tO\nof\tO\nCYA\tB-Chemical\nper\tO\nbody\tO\nsurface\tO\narea\tO\nwas\tO\ncalculated\tO\nfor\tO\nall\tO\npatients\tO\nand\tO\nthe\tO\npatients\tO\nwere\tO\ndivided\tO\ninto\tO\ntwo\tO\ngroups\tO\nbased\tO\non\tO\ndaily\tO\nCYA\tB-Chemical\ndose\tO\n:\tO\nGroup\tO\n1\tO\n,\tO\nCYA\tB-Chemical\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n1\tO\n.\tO\n55\tO\ng\tO\n/\tO\nm2\tO\n/\tO\nd\tO\n;\tO\nGroup\tO\n2\tO\n,\tO\nCYA\tB-Chemical\ngreater\tO\nthan\tO\n1\tO\n.\tO\n55\tO\ng\tO\n/\tO\nm2\tO\n/\tO\nd\tO\n.\tO\n\nCardiotoxicity\tB-Disease\nthat\tO\nwas\tO\nthought\tO\nto\tO\nbe\tO\nrelated\tO\nto\tO\nCYA\tB-Chemical\noccurred\tO\nin\tO\n1\tO\n/\tO\n32\tO\n(\tO\n3\tO\n%\tO\n)\tO\nof\tO\npatients\tO\nin\tO\nGroup\tO\n1\tO\nand\tO\nin\tO\n13\tO\n/\tO\n52\tO\n(\tO\n25\tO\n%\tO\n)\tO\npatients\tO\nin\tO\nGroup\tO\n2\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nCongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\ncaused\tO\nor\tO\ncontributed\tO\nto\tO\ndeath\tO\nin\tO\n0\tO\n/\tO\n32\tO\npatients\tO\nin\tO\nGroup\tO\n1\tO\nv\tO\n6\tO\n/\tO\n52\tO\n(\tO\n12\tO\n%\tO\n)\tO\nof\tO\npatients\tO\nin\tO\nGroup\tO\n2\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n25\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\ndifference\tO\nin\tO\nthe\tO\nrate\tO\nof\tO\nengraftment\tO\nof\tO\nevaluable\tO\npatients\tO\nin\tO\nthe\tO\ntwo\tO\ngroups\tO\n(\tO\nP\tO\ngreater\tO\nthan\tO\n0\tO\n.\tO\n5\tO\n)\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nthe\tO\nCYA\tB-Chemical\ncardiotoxicity\tB-Disease\ncorrelates\tO\nwith\tO\nCYA\tB-Chemical\ndosage\tO\nas\tO\ncalculated\tO\nby\tO\nbody\tO\nsurface\tO\narea\tO\n,\tO\nand\tO\nthat\tO\npatients\tO\nwith\tO\naplastic\tB-Disease\nanemia\tI-Disease\nand\tO\nimmunodeficiencies\tB-Disease\ncan\tO\nbe\tO\neffectively\tO\nprepared\tO\nfor\tO\nbone\tO\nmarrow\tO\ngrafting\tO\nat\tO\na\tO\nCYA\tB-Chemical\ndose\tO\nof\tO\n1\tO\n.\tO\n55\tO\ng\tO\n/\tO\nm2\tO\n/\tO\nd\tO\nfor\tO\nfour\tO\ndays\tO\nwith\tO\na\tO\nlower\tO\nincidence\tO\nof\tO\ncardiotoxicity\tB-Disease\nthan\tO\npatients\tO\nwhose\tO\nCYA\tB-Chemical\ndosage\tO\nis\tO\ncalculated\tO\nbased\tO\non\tO\nweight\tO\n.\tO\n\nThis\tO\nstudy\tO\nreaffirms\tO\nthe\tO\nprinciple\tO\nthat\tO\ndrug\tO\ntoxicity\tB-Disease\ncorrelates\tO\nwith\tO\ndose\tO\nper\tO\nbody\tO\nsurface\tO\narea\tO\n.\tO\n\nStudies\tO\nof\tO\nrisk\tO\nfactors\tO\nfor\tO\naminoglycoside\tB-Chemical\nnephrotoxicity\tB-Disease\n.\tO\n\nThe\tO\nepidemiology\tO\nof\tO\naminoglycoside\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\nis\tO\nnot\tO\nfully\tO\nunderstood\tO\n.\tO\n\nExperimental\tO\nstudies\tO\nin\tO\nhealthy\tO\nhuman\tO\nvolunteers\tO\nindicate\tO\naminoglycosides\tB-Chemical\ncause\tO\nproximal\tO\ntubular\tO\ndamage\tO\nin\tO\nmost\tO\npatients\tO\n,\tO\nbut\tO\nrarely\tO\n,\tO\nif\tO\never\tO\n,\tO\ncause\tO\nglomerular\tB-Disease\nor\tI-Disease\ntubular\tI-Disease\ndysfunction\tI-Disease\n.\tO\n\nClinical\tO\ntrials\tO\nof\tO\naminoglycosides\tB-Chemical\nin\tO\nseriously\tO\nill\tO\npatients\tO\nindicate\tO\nthat\tO\nthe\tO\nrelative\tO\nrisk\tO\nfor\tO\ndeveloping\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nduring\tO\ntherapy\tO\nranges\tO\nfrom\tO\n8\tO\nto\tO\n10\tO\nand\tO\nthat\tO\nthe\tO\nattributable\tO\nrisk\tO\nis\tO\n70\tO\n%\tO\nto\tO\n80\tO\n%\tO\n.\tO\n\nFurther\tO\nanalysis\tO\nof\tO\nthese\tO\ndata\tO\nsuggests\tO\nthat\tO\nthe\tO\nduration\tO\nof\tO\ntherapy\tO\n,\tO\nplasma\tO\naminoglycoside\tB-Chemical\nlevels\tO\n,\tO\nliver\tB-Disease\ndisease\tI-Disease\n,\tO\nadvanced\tO\nage\tO\n,\tO\nhigh\tO\ninitial\tO\nestimated\tO\ncreatinine\tB-Chemical\nclearance\tO\nand\tO\n,\tO\npossibly\tO\n,\tO\nfemale\tO\ngender\tO\nall\tO\nincrease\tO\nthe\tO\nrisk\tO\nfor\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nOther\tO\ncauses\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nsuch\tO\nas\tO\nshock\tB-Disease\n,\tO\nappear\tO\nto\tO\nhave\tO\nan\tO\nadditive\tO\neffect\tO\n.\tO\n\nPredictive\tO\nmodels\tO\nhave\tO\nbeen\tO\ndeveloped\tO\nfrom\tO\nthese\tO\nanalyses\tO\nthat\tO\nshould\tO\nbe\tO\nuseful\tO\nfor\tO\nidentifying\tO\npatients\tO\nat\tO\nhigh\tO\nrisk\tO\n.\tO\n\nThese\tO\nmodels\tO\nmay\tO\nalso\tO\nbe\tO\nuseful\tO\nin\tO\ndeveloping\tO\ninsights\tO\ninto\tO\nthe\tO\npathophysiology\tO\nof\tO\naminoglycoside\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nCentral\tO\naction\tO\nof\tO\nnarcotic\tO\nanalgesics\tO\n.\tO\n\nPart\tO\nIV\tO\n.\tO\n\nNoradrenergic\tO\ninfluences\tO\non\tO\nthe\tO\nactivity\tO\nof\tO\nanalgesics\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nclonidine\tB-Chemical\n,\tO\nnaphazoline\tB-Chemical\nand\tO\nxylometazoline\tB-Chemical\non\tO\nanalgesia\tO\ninduced\tO\nby\tO\nmorphine\tB-Chemical\n,\tO\ncodeine\tB-Chemical\n,\tO\nfentanyl\tB-Chemical\nand\tO\npentazocine\tB-Chemical\n,\tO\nand\tO\non\tO\ncataleptic\tB-Disease\neffect\tO\nof\tO\nmorphine\tB-Chemical\n,\tO\ncodine\tB-Chemical\nand\tO\nfentanyl\tB-Chemical\nwas\tO\nstudied\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nbiochemical\tO\nassays\tO\non\tO\nthe\tO\ninfluence\tO\nof\tO\nfour\tO\nanalgesics\tO\non\tO\nthe\tO\nbrain\tO\nconcentration\tO\nand\tO\nturnover\tO\nof\tO\nnoradrenaline\tB-Chemical\n(\tO\nNA\tB-Chemical\n)\tO\nwere\tO\nalso\tO\nperformed\tO\n.\tO\n\nIt\tO\nwas\tO\nfound\tO\nthat\tO\nthree\tO\ndrugs\tO\nstimulating\tO\ncentral\tO\nNA\tB-Chemical\nreceptors\tO\nfailed\tO\nto\tO\naffect\tO\nthe\tO\nanalgesic\tO\nED50\tO\nof\tO\nall\tO\nantinociceptive\tO\nagents\tO\nand\tO\nthey\tO\nenhanced\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nmorphine\tB-Chemical\nand\tO\nfentanyl\tB-Chemical\n.\tO\n\nCodeine\tB-Chemical\ncatalepsy\tB-Disease\nwas\tO\nincreased\tO\nby\tO\nclonidine\tB-Chemical\nand\tO\ndecreased\tO\nby\tO\nnaphazoline\tB-Chemical\nand\tO\nxylometazoline\tB-Chemical\n.\tO\n\nThe\tO\nbrain\tO\nconcentration\tO\nof\tO\nNA\tB-Chemical\nwas\tO\nnot\tO\nchanged\tO\nby\tO\nmorphine\tB-Chemical\nand\tO\nfentanyl\tB-Chemical\n,\tO\nbut\tO\none\tO\nof\tO\nthe\tO\ndoses\tO\nof\tO\ncodeine\tB-Chemical\n(\tO\n45\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nslightly\tO\nenhanced\tO\nit\tO\n.\tO\n\nPentazocine\tB-Chemical\ndose\tO\n-\tO\ndependently\tO\ndecreased\tO\nthe\tO\nbrain\tO\nlevel\tO\nof\tO\nNA\tB-Chemical\n.\tO\n\nThe\tO\nrate\tO\nof\tO\nNA\tB-Chemical\nturnover\tO\nwas\tO\nnot\tO\naltered\tO\nby\tO\nanalgesics\tO\nexcept\tO\nfor\tO\nthe\tO\nhigher\tO\ndose\tO\nof\tO\nfentanyl\tB-Chemical\n(\tO\n0\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nfollowing\tO\nwhich\tO\nthe\tO\ndisappearance\tO\nof\tO\nNA\tB-Chemical\nfrom\tO\nthe\tO\nbrain\tO\nwas\tO\ndiminished\tO\n.\tO\n\nThe\tO\nresults\tO\nare\tO\ndiscussed\tO\nin\tO\nthe\tO\nlight\tO\nof\tO\nvarious\tO\nand\tO\nnon\tO\n-\tO\nuniform\tO\ndata\tO\nfrom\tO\nthe\tO\nliterature\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\nin\tO\nrats\tO\nthe\tO\nbrain\tO\nNA\tB-Chemical\nplays\tO\na\tO\nless\tO\nimportant\tO\nfunction\tO\nthan\tO\nthe\tO\nother\tO\nmonoamines\tB-Chemical\nin\tO\nthe\tO\nbehavioural\tO\nactivity\tO\nof\tO\npotent\tO\nanalgesics\tO\n.\tO\n\nFlurothyl\tB-Chemical\nseizure\tB-Disease\nthresholds\tO\nin\tO\nmice\tO\ntreated\tO\nneonatally\tO\nwith\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\nmonosodium\tB-Chemical\nglutamate\tI-Chemical\n(\tO\nMSG\tB-Chemical\n)\tO\n:\tO\nevaluation\tO\nof\tO\nexperimental\tO\nparameters\tO\nin\tO\nflurothyl\tB-Chemical\nseizure\tB-Disease\ntesting\tO\n.\tO\n\nMonosodium\tB-Chemical\nglutamate\tI-Chemical\n(\tO\nMSG\tB-Chemical\n)\tO\nadministration\tO\nto\tO\nneonatal\tO\nrodents\tO\nproduces\tO\nconvulsions\tB-Disease\nand\tO\nresults\tO\nin\tO\nnumerous\tO\nbiochemical\tO\nand\tO\nbehavioral\tO\ndeficits\tO\n.\tO\n\nThese\tO\nstudies\tO\nwere\tO\nundertaken\tO\nto\tO\ndetermine\tO\nif\tO\nneonatal\tO\nadministration\tO\nof\tO\nMSG\tB-Chemical\nproduced\tO\npermanent\tO\nalterations\tO\nin\tO\nseizure\tB-Disease\nsusceptibility\tO\n,\tO\nsince\tO\nprevious\tO\ninvestigations\tO\nwere\tO\ninconclusive\tO\n.\tO\n\nA\tO\nflurothyl\tB-Chemical\nether\tB-Chemical\nseizure\tB-Disease\nscreening\tO\ntechnique\tO\nwas\tO\nused\tO\nto\tO\nevaluate\tO\nseizure\tB-Disease\nsusceptibility\tO\nin\tO\nadult\tO\nmice\tO\nthat\tO\nreceived\tO\nneonatal\tO\ninjections\tO\nof\tO\nMSG\tB-Chemical\n(\tO\n4\tO\nmg\tO\n/\tO\ng\tO\nand\tO\n1\tO\nmg\tO\n/\tO\ng\tO\n)\tO\n.\tO\n\nMSG\tB-Chemical\ntreatment\tO\nresulted\tO\nin\tO\nsignificant\tO\nreductions\tO\nin\tO\nwhole\tO\nbrain\tO\nweight\tO\nbut\tO\ndid\tO\nnot\tO\nalter\tO\nseizure\tB-Disease\nthreshold\tO\n.\tO\n\nA\tO\nnaloxone\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nchallenge\tO\nwas\tO\nalso\tO\nineffective\tO\nin\tO\naltering\tO\nthe\tO\nseizure\tB-Disease\nthresholds\tO\nof\tO\neither\tO\ncontrol\tO\nof\tO\nMSG\tB-Chemical\n-\tO\ntreated\tO\nmice\tO\n.\tO\n\nFlurothyl\tB-Chemical\nether\tB-Chemical\nproduced\tO\nhypothermia\tB-Disease\nwhich\tO\nwas\tO\ncorrelated\tO\nwith\tO\nthe\tO\nduration\tO\nof\tO\nflurothyl\tB-Chemical\nexposure\tO\n;\tO\nhowever\tO\n,\tO\nthe\tO\nrelationship\tO\nof\tO\nhypothermia\tB-Disease\nto\tO\nseizure\tB-Disease\ninduction\tO\nwas\tO\nunclear\tO\n.\tO\n\nFlurothyl\tB-Chemical\nseizure\tB-Disease\ntesting\tO\nproved\tO\nto\tO\nbe\tO\na\tO\nrapid\tO\nand\tO\nreliable\tO\ntechnique\tO\nwith\tO\nwhich\tO\nto\tO\nevaluate\tO\nseizure\tB-Disease\nsusceptibility\tO\n.\tO\n\nSusceptibility\tO\nto\tO\nseizures\tB-Disease\nproduced\tO\nby\tO\npilocarpine\tB-Chemical\nin\tO\nrats\tO\nafter\tO\nmicroinjection\tO\nof\tO\nisoniazid\tB-Chemical\nor\tO\ngamma\tB-Chemical\n-\tI-Chemical\nvinyl\tI-Chemical\n-\tI-Chemical\nGABA\tI-Chemical\ninto\tO\nthe\tO\nsubstantia\tO\nnigra\tO\n.\tO\n\nPilocarpine\tB-Chemical\n,\tO\ngiven\tO\nintraperitoneally\tO\nto\tO\nrats\tO\n,\tO\nreproduces\tO\nthe\tO\nneuropathological\tO\nsequelae\tO\nof\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\nand\tO\nprovides\tO\na\tO\nrelevant\tO\nanimal\tO\nmodel\tO\nfor\tO\nstudying\tO\nmechanisms\tO\nof\tO\nbuildup\tO\nof\tO\nconvulsive\tB-Disease\nactivity\tO\nand\tO\npathways\tO\noperative\tO\nin\tO\nthe\tO\ngeneralization\tO\nand\tO\npropagation\tO\nof\tO\nseizures\tB-Disease\nwithin\tO\nthe\tO\nforebrain\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthe\tO\neffects\tO\nof\tO\nmanipulating\tO\nthe\tO\nactivity\tO\nof\tO\nthe\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n(\tO\nGABA\tB-Chemical\n)\tO\n-\tO\nmediated\tO\nsynaptic\tO\ninhibition\tO\nwithin\tO\nthe\tO\nsubstantia\tO\nnigra\tO\non\tO\nseizures\tB-Disease\nproduced\tO\nby\tO\npilocarpine\tB-Chemical\nin\tO\nrats\tO\n,\tO\nwere\tO\ninvestigated\tO\n.\tO\n\nIn\tO\nanimals\tO\npretreated\tO\nwith\tO\nmicroinjections\tO\nof\tO\nisoniazid\tB-Chemical\n,\tO\n150\tO\nmicrograms\tO\n,\tO\nan\tO\ninhibitor\tO\nof\tO\nactivity\tO\nof\tO\nthe\tO\nGABA\tB-Chemical\n-\tO\nsynthesizing\tO\nenzyme\tO\n,\tO\nL\tB-Chemical\n-\tI-Chemical\nglutamic\tI-Chemical\nacid\tI-Chemical\ndecarboxylase\tO\n,\tO\ninto\tO\nthe\tO\nsubstantia\tO\nnigra\tO\npars\tO\nreticulata\tO\n(\tO\nSNR\tO\n)\tO\n,\tO\nbilaterally\tO\n,\tO\nnon\tO\n-\tO\nconvulsant\tO\ndoses\tO\nof\tO\npilocarpine\tB-Chemical\n,\tO\n100\tO\nand\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nresulted\tO\nin\tO\nsevere\tO\nmotor\tO\nlimbic\tO\nseizures\tB-Disease\nand\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n.\tO\n\nElectroencephalographic\tO\nand\tO\nbehavioral\tO\nmonitoring\tO\nrevealed\tO\na\tO\nprofound\tO\nreduction\tO\nof\tO\nthe\tO\nthreshold\tO\nfor\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nMorphological\tO\nanalysis\tO\nof\tO\nfrontal\tO\nforebrain\tO\nsections\tO\nwith\tO\nlight\tO\nmicroscopy\tO\nrevealed\tO\nseizure\tB-Disease\n-\tO\nrelated\tO\ndamage\tO\nto\tO\nthe\tO\nhippocampal\tO\nformation\tO\n,\tO\nthalamus\tO\n,\tO\namygdala\tO\n,\tO\nolfactory\tO\ncortex\tO\n,\tO\nsubstantia\tO\nnigra\tO\nand\tO\nneocortex\tO\n,\tO\nwhich\tO\nis\tO\ntypically\tO\nobserved\tO\nwith\tO\npilocarpine\tB-Chemical\nin\tO\ndoses\tO\nexceeding\tO\n350\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nBilateral\tO\nintrastriatal\tO\ninjections\tO\nof\tO\nisoniazid\tB-Chemical\ndid\tO\nnot\tO\naugment\tO\nseizures\tB-Disease\nproduced\tO\nby\tO\npilocarpine\tB-Chemical\n,\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nApplication\tO\nof\tO\nan\tO\nirreversible\tO\ninhibitor\tO\nof\tO\nGABA\tB-Chemical\ntransaminase\tO\n,\tO\ngamma\tB-Chemical\n-\tI-Chemical\nvinyl\tI-Chemical\n-\tI-Chemical\nGABA\tI-Chemical\n(\tO\nD\tB-Chemical\n,\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\namino\tI-Chemical\n-\tI-Chemical\nhex\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\nenoic\tI-Chemical\nacid\tI-Chemical\n)\tO\n,\tO\n5\tO\nmicrograms\tO\n,\tO\ninto\tO\nthe\tO\nSNR\tO\n,\tO\nbilaterally\tO\n,\tO\nsuppressed\tO\nthe\tO\nappearance\tO\nof\tO\nelectrographic\tO\nand\tO\nbehavioral\tO\nseizures\tB-Disease\nproduced\tO\nby\tO\npilocarpine\tB-Chemical\n,\tO\n380\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nThis\tO\ntreatment\tO\nwas\tO\nalso\tO\nsufficient\tO\nto\tO\nprotect\tO\nanimals\tO\nfrom\tO\nthe\tO\noccurrence\tO\nof\tO\nbrain\tB-Disease\ndamage\tI-Disease\n.\tO\n\nMicroinjections\tO\nof\tO\ngamma\tB-Chemical\n-\tI-Chemical\nvinyl\tI-Chemical\n-\tI-Chemical\nGABA\tI-Chemical\n,\tO\n5\tO\nmicrograms\tO\n,\tO\ninto\tO\nthe\tO\ndorsal\tO\nstriatum\tO\n,\tO\nbilaterally\tO\n,\tO\nfailed\tO\nto\tO\nprevent\tO\nthe\tO\ndevelopment\tO\nof\tO\nconvulsions\tB-Disease\nproduced\tO\nby\tO\npilocarpine\tB-Chemical\n,\tO\n380\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nThe\tO\nresults\tO\ndemonstrate\tO\nthat\tO\nthe\tO\nthreshold\tO\nfor\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nin\tO\nrats\tO\nis\tO\nsubjected\tO\nto\tO\nthe\tO\nregulation\tO\nof\tO\nthe\tO\nGABA\tB-Chemical\n-\tO\nmediated\tO\nsynaptic\tO\ninhibition\tO\nwithin\tO\nthe\tO\nsubstantia\tO\nnigra\tO\n.\tO\n\nHuman\tO\nand\tO\ncanine\tO\nventricular\tO\nvasoactive\tO\nintestinal\tO\npolypeptide\tO\n:\tO\ndecrease\tO\nwith\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nVasoactive\tO\nintestinal\tO\npolypeptide\tO\n(\tO\nVIP\tO\n)\tO\nis\tO\na\tO\nsystemic\tO\nand\tO\ncoronary\tO\nvasodilator\tO\nthat\tO\nmay\tO\nhave\tO\npositive\tO\ninotropic\tO\nproperties\tO\n.\tO\n\nMyocardial\tO\nlevels\tO\nof\tO\nVIP\tO\nwere\tO\nassayed\tO\nbefore\tO\nand\tO\nafter\tO\nthe\tO\ndevelopment\tO\nof\tO\nheart\tB-Disease\nfailure\tI-Disease\nin\tO\ntwo\tO\ncanine\tO\nmodels\tO\n.\tO\n\nIn\tO\nthe\tO\nfirst\tO\n,\tO\ncobalt\tB-Chemical\ncardiomyopathy\tB-Disease\nwas\tO\ninduced\tO\nin\tO\neight\tO\ndogs\tO\n;\tO\nVIP\tO\n(\tO\nby\tO\nradioimmunoassay\tO\n)\tO\ndecreased\tO\nfrom\tO\n35\tO\n+\tO\n/\tO\n-\tO\n11\tO\npg\tO\n/\tO\nmg\tO\nprotein\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nto\tO\n5\tO\n+\tO\n/\tO\n-\tO\n4\tO\npg\tO\n/\tO\nmg\tO\nprotein\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nIn\tO\nsix\tO\ndogs\tO\nwith\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\nheart\tB-Disease\nfailure\tI-Disease\n,\tO\nVIP\tO\ndecreased\tO\nfrom\tO\n31\tO\n+\tO\n/\tO\n-\tO\n7\tO\nto\tO\n11\tO\n+\tO\n/\tO\n-\tO\n4\tO\npg\tO\n/\tO\nmg\tO\nprotein\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nVIP\tO\ncontent\tO\nof\tO\nleft\tO\nventricular\tO\nmuscle\tO\nof\tO\nresected\tO\nfailing\tO\nhearts\tO\nin\tO\n10\tO\npatients\tO\nreceiving\tO\na\tO\nheart\tO\ntransplant\tO\nwas\tO\ncompared\tO\nwith\tO\nthe\tO\npapillary\tO\nmuscles\tO\nin\tO\n14\tO\npatients\tO\n(\tO\nfive\tO\nwith\tO\nrheumatic\tB-Disease\ndisease\tI-Disease\n,\tO\nnine\tO\nwith\tO\nmyxomatous\tB-Disease\ndegeneration\tI-Disease\n)\tO\nreceiving\tO\nmitral\tO\nvalve\tO\nprostheses\tO\n.\tO\n\nThe\tO\nlowest\tO\nmyocardial\tO\nVIP\tO\nconcentration\tO\nwas\tO\nfound\tO\nin\tO\nthe\tO\nhearts\tO\nof\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\ndisease\tI-Disease\n(\tO\none\tO\npatient\tO\nreceiving\tO\na\tO\ntransplant\tO\nand\tO\nthree\tO\nreceiving\tO\nmitral\tO\nprostheses\tO\n)\tO\n(\tO\n6\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n9\tO\npg\tO\n/\tO\nmg\tO\nprotein\tO\n)\tO\n.\tO\n\nThe\tO\nother\tO\npatients\tO\nundergoing\tO\ntransplantation\tO\nhad\tO\nan\tO\naverage\tO\nejection\tO\nfraction\tO\nof\tO\n17\tO\n%\tO\n+\tO\n/\tO\n-\tO\n6\tO\n%\tO\nand\tO\na\tO\nVIP\tO\nlevel\tO\nof\tO\n8\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n9\tO\npg\tO\n/\tO\nmg\tO\nprotein\tO\n.\tO\n\nThe\tO\nhearts\tO\nwithout\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n(\tO\naverage\tO\nejection\tO\nfraction\tO\nof\tO\nthis\tO\ngroup\tO\n62\tO\n%\tO\n+\tO\n/\tO\n-\tO\n10\tO\n%\tO\n)\tO\nhad\tO\na\tO\nVIP\tO\nconcentration\tO\nof\tO\n14\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n7\tO\n.\tO\n9\tO\npg\tO\n/\tO\nmg\tO\nprotein\tO\n,\tO\nand\tO\nthis\tO\nwas\tO\ngreater\tO\nthan\tO\nin\tO\nhearts\tO\nof\tO\nthe\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\ndisease\tI-Disease\nand\tO\nthe\tO\nhearts\tO\nof\tO\npatients\tO\nreceiving\tO\na\tO\ntransplant\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nMyocardial\tO\ncatecholamines\tB-Chemical\nwere\tO\nalso\tO\ndetermined\tO\nin\tO\n14\tO\nsubjects\tO\n;\tO\na\tO\nweak\tO\ncorrelation\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n57\tO\n,\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nbetween\tO\nthe\tO\ntissue\tO\nconcentrations\tO\nof\tO\nVIP\tO\nand\tO\nnorepinephrine\tB-Chemical\nwas\tO\nnoted\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nNon\tO\n-\tO\ninvasive\tO\ndetection\tO\nof\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nby\tO\nbody\tO\nsurface\tO\nelectrocardiographic\tO\nmapping\tO\nafter\tO\ndipyridamole\tB-Chemical\ninfusion\tO\n.\tO\n\nElectrocardiographic\tO\nchanges\tO\nafter\tO\ndipyridamole\tB-Chemical\ninfusion\tO\n(\tO\n0\tO\n.\tO\n568\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\n4\tO\nmin\tO\n)\tO\nwere\tO\nstudied\tO\nin\tO\n41\tO\npatients\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nand\tO\ncompared\tO\nwith\tO\nthose\tO\nafter\tO\nsubmaximal\tO\ntreadmill\tO\nexercise\tO\nby\tO\nuse\tO\nof\tO\nthe\tO\nbody\tO\nsurface\tO\nmapping\tO\ntechnique\tO\n.\tO\n\nPatients\tO\nwere\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n;\tO\n19\tO\npatients\tO\nwithout\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n(\tO\nnon\tO\n-\tO\nMI\tB-Disease\ngroup\tO\n)\tO\n,\tO\n14\tO\nwith\tO\nanterior\tB-Disease\ninfarction\tI-Disease\n(\tO\nANT\tB-Disease\n-\tI-Disease\nMI\tI-Disease\n)\tO\nand\tO\neight\tO\nwith\tO\ninferior\tB-Disease\ninfarction\tI-Disease\n(\tO\nINF\tB-Disease\n-\tI-Disease\nMI\tI-Disease\n)\tO\n.\tO\n\nEighty\tO\n-\tO\nseven\tO\nunipolar\tO\nelectrocardiograms\tO\n(\tO\nECGs\tO\n)\tO\ndistributed\tO\nover\tO\nthe\tO\nentire\tO\nthoracic\tO\nsurface\tO\nwere\tO\nsimultaneously\tO\nrecorded\tO\n.\tO\n\nAfter\tO\ndipyridamole\tB-Chemical\n,\tO\nischemic\tB-Disease\nST\tO\n-\tO\nsegment\tO\ndepression\tB-Disease\n(\tO\n0\tO\n.\tO\n05\tO\nmV\tO\nor\tO\nmore\tO\n)\tO\nwas\tO\nobserved\tO\nin\tO\n84\tO\n%\tO\nof\tO\nthe\tO\nnon\tO\n-\tO\nMI\tB-Disease\ngroup\tO\n,\tO\n29\tO\n%\tO\nof\tO\nthe\tO\nANT\tB-Disease\n-\tI-Disease\nMI\tI-Disease\ngroup\tO\n,\tO\n63\tO\n%\tO\nof\tO\nthe\tO\nINF\tB-Disease\n-\tI-Disease\nMI\tI-Disease\ngroup\tO\nand\tO\n61\tO\n%\tO\nof\tO\nthe\tO\ntotal\tO\npopulation\tO\n.\tO\n\nExercise\tO\n-\tO\ninduced\tO\nST\tO\ndepression\tB-Disease\nwas\tO\nobserved\tO\nin\tO\n84\tO\n%\tO\nof\tO\nthe\tO\nnon\tO\n-\tO\nMI\tB-Disease\ngroup\tO\n,\tO\n43\tO\n%\tO\nof\tO\nthe\tO\nANT\tB-Disease\n-\tI-Disease\nMI\tI-Disease\ngroup\tO\n,\tO\n38\tO\n%\tO\nof\tO\nthe\tO\nINF\tB-Disease\n-\tI-Disease\nMI\tI-Disease\ngroup\tO\nand\tO\n61\tO\n%\tO\nof\tO\nthe\tO\ntotal\tO\n.\tO\n\nFor\tO\nindividual\tO\npatients\tO\n,\tO\nthere\tO\nwere\tO\nno\tO\nobvious\tO\ndifferences\tO\nbetween\tO\nthe\tO\nbody\tO\nsurface\tO\ndistribution\tO\nof\tO\nST\tO\ndepression\tB-Disease\nin\tO\nboth\tO\ntests\tO\n.\tO\n\nThe\tO\nincrease\tO\nin\tO\npressure\tO\nrate\tO\nproduct\tO\nafter\tO\ndipyridamole\tB-Chemical\nwas\tO\nsignificantly\tO\nless\tO\nthan\tO\nthat\tO\nduring\tO\nthe\tO\ntreadmill\tO\nexercise\tO\n.\tO\n\nThe\tO\ndata\tO\nsuggest\tO\nthat\tO\nthe\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\nis\tO\ncaused\tO\nby\tO\nthe\tO\ninhomogenous\tO\ndistribution\tO\nof\tO\nmyocardial\tO\nblood\tO\nflow\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nthe\tO\ndipyridamole\tB-Chemical\nECG\tO\ntest\tO\nis\tO\nas\tO\nuseful\tO\nas\tO\nthe\tO\nexercise\tO\nECG\tO\ntest\tO\nfor\tO\nthe\tO\nassessment\tO\nof\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n.\tO\n\nBradycardia\tB-Disease\nafter\tO\nhigh\tO\n-\tO\ndose\tO\nintravenous\tO\nmethylprednisolone\tB-Chemical\ntherapy\tO\n.\tO\n\nIn\tO\n5\tO\nconsecutive\tO\npatients\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\nwho\tO\nreceived\tO\nintravenous\tO\nhigh\tO\n-\tO\ndose\tO\nmethylprednisolone\tB-Chemical\n(\tO\nMP\tB-Chemical\n)\tO\ntherapy\tO\n(\tO\n1\tO\ng\tO\ndaily\tO\nfor\tO\n2\tO\nor\tO\n3\tO\nconsecutive\tO\ndays\tO\n)\tO\n,\tO\na\tO\ndecline\tO\nin\tO\npulse\tO\nrate\tO\nwas\tO\nobserved\tO\n,\tO\nmost\tO\npronounced\tO\non\tO\nday\tO\n4\tO\n.\tO\n\nIn\tO\none\tO\nof\tO\nthe\tO\n5\tO\npatients\tO\nthe\tO\nbradycardia\tB-Disease\nwas\tO\nassociated\tO\nwith\tO\ncomplaints\tO\nof\tO\nsubsternal\tO\npressure\tO\n.\tO\n\nReversal\tO\nto\tO\nnormal\tO\nheart\tO\nrate\tO\nwas\tO\nfound\tO\non\tO\nday\tO\n7\tO\n.\tO\n\nElectrocardiographic\tO\nregistrations\tO\nshowed\tO\nsinus\tB-Disease\nbradycardia\tI-Disease\nin\tO\nall\tO\ncases\tO\n.\tO\n\nNo\tO\nsignificant\tO\nchanges\tO\nin\tO\nplasma\tO\nconcentrations\tO\nof\tO\nelectrolytes\tO\nwere\tO\nfound\tO\n.\tO\n\nCareful\tO\nobservation\tO\nof\tO\npatients\tO\nreceiving\tO\nhigh\tO\n-\tO\ndose\tO\nMP\tB-Chemical\nis\tO\nrecommended\tO\n.\tO\n\nHigh\tO\n-\tO\ndose\tO\nMP\tB-Chemical\nmay\tO\nbe\tO\ncontraindicated\tO\nin\tO\npatients\tO\nwith\tO\nknown\tO\nheart\tB-Disease\ndisease\tI-Disease\n.\tO\n\nTwo\tO\ncases\tO\nof\tO\ndownbeat\tB-Disease\nnystagmus\tI-Disease\nand\tO\noscillopsia\tB-Disease\nassociated\tO\nwith\tO\ncarbamazepine\tB-Chemical\n.\tO\n\nDownbeat\tB-Disease\nnystagmus\tI-Disease\nis\tO\noften\tO\nassociated\tO\nwith\tO\nstructural\tO\nlesions\tO\nat\tO\nthe\tO\ncraniocervical\tO\njunction\tO\n,\tO\nbut\tO\nhas\tO\noccasionally\tO\nbeen\tO\nreported\tO\nas\tO\na\tO\nmanifestation\tO\nof\tO\nmetabolic\tO\nimbalance\tO\nor\tO\ndrug\tO\nintoxication\tO\n.\tO\n\nWe\tO\nrecorded\tO\nthe\tO\neye\tO\nmovements\tO\nof\tO\ntwo\tO\npatients\tO\nwith\tO\nreversible\tO\ndownbeat\tB-Disease\nnystagmus\tI-Disease\nrelated\tO\nto\tO\ncarbamazepine\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\nnystagmus\tB-Disease\nof\tO\nboth\tO\npatients\tO\nresolved\tO\nafter\tO\nreduction\tO\nof\tO\nthe\tO\nserum\tO\ncarbamazepine\tB-Chemical\nlevels\tO\n.\tO\n\nNeuroradiologic\tO\ninvestigations\tO\nincluding\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nscans\tO\nin\tO\nboth\tO\npatients\tO\nshowed\tO\nno\tO\nevidence\tO\nof\tO\nintracranial\tO\nabnormality\tO\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\ndownbeat\tB-Disease\nnystagmus\tI-Disease\nwho\tO\nare\tO\ntaking\tO\nanticonvulsant\tO\nmedications\tO\n,\tO\nconsideration\tO\nshould\tO\nbe\tO\ngiven\tO\nto\tO\nreduction\tO\nin\tO\ndose\tO\nbefore\tO\nfurther\tO\ninvestigation\tO\nis\tO\nundertaken\tO\n.\tO\n\nImprovement\tO\nby\tO\ndenopamine\tB-Chemical\n(\tO\nTA\tB-Chemical\n-\tI-Chemical\n064\tI-Chemical\n)\tO\nof\tO\npentobarbital\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\nfailure\tI-Disease\nin\tO\nthe\tO\ndog\tO\nheart\tO\n-\tO\nlung\tO\npreparation\tO\n.\tO\n\nThe\tO\nefficacy\tO\nof\tO\ndenopamine\tB-Chemical\n,\tO\nan\tO\norally\tO\nactive\tO\nbeta\tO\n1\tO\n-\tO\nadrenoceptor\tO\nagonist\tO\n,\tO\nin\tO\nimproving\tO\ncardiac\tB-Disease\nfailure\tI-Disease\nwas\tO\nassessed\tO\nin\tO\ndog\tO\nheart\tO\n-\tO\nlung\tO\npreparations\tO\n.\tO\n\nCardiac\tO\nfunctions\tO\ndepressed\tO\nby\tO\npentobarbital\tB-Chemical\n(\tO\n118\tO\n+\tO\n/\tO\n-\tO\n28\tO\nmg\tO\n;\tO\nmean\tO\nvalue\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nsuch\tO\nthat\tO\ncardiac\tO\noutput\tO\nand\tO\nmaximum\tO\nrate\tO\nof\tO\nrise\tO\nof\tO\nleft\tO\nventricular\tO\npressure\tO\n(\tO\nLV\tO\ndP\tO\n/\tO\ndt\tO\nmax\tO\n)\tO\nhad\tO\nbeen\tO\nreduced\tO\nby\tO\nabout\tO\n35\tO\n%\tO\nand\tO\n26\tO\n%\tO\nof\tO\nthe\tO\nrespective\tO\ncontrols\tO\nwere\tO\nimproved\tO\nby\tO\ndenopamine\tB-Chemical\n(\tO\n10\tO\n-\tO\n300\tO\nmicrograms\tO\n)\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nWith\tO\n100\tO\nmicrograms\tO\ndenopamine\tB-Chemical\n,\tO\nalmost\tO\ncomplete\tO\nrestoration\tO\nof\tO\ncardiac\tO\nperformance\tO\nwas\tO\nattained\tO\n,\tO\nassociated\tO\nwith\tO\na\tO\nslight\tO\nincrease\tO\nin\tO\nheart\tO\nrate\tO\n.\tO\n\nNo\tO\narrhythmias\tB-Disease\nwere\tO\ninduced\tO\nby\tO\nthese\tO\ndoses\tO\nof\tO\ndenopamine\tB-Chemical\n.\tO\n\nThe\tO\nresults\tO\nwarrant\tO\nclinical\tO\ntrials\tO\nof\tO\ndenopamine\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\ncardiac\tB-Disease\nfailure\tI-Disease\n.\tO\n\nClonazepam\tB-Chemical\nmonotherapy\tO\nfor\tO\nepilepsy\tB-Disease\nin\tO\nchildhood\tO\n.\tO\n\nSixty\tO\npatients\tO\n(\tO\nage\tO\n-\tO\nrange\tO\none\tO\nmonth\tO\nto\tO\n14\tO\nyears\tO\n)\tO\nwith\tO\nother\tO\ntypes\tO\nof\tO\nepilepsy\tB-Disease\nthan\tO\ninfantile\tB-Disease\nspasms\tI-Disease\nwere\tO\ntreated\tO\nwith\tO\nclonazepam\tB-Chemical\n.\tO\n\nDisappearance\tO\nof\tO\nseizures\tB-Disease\nand\tO\nnormalization\tO\nof\tO\nabnormal\tO\nEEG\tO\nwith\tO\ndisappearance\tO\nof\tO\nseizures\tB-Disease\nwere\tO\nrecognized\tO\nin\tO\n77\tO\n%\tO\nand\tO\n50\tO\n%\tO\n,\tO\nrespectively\tO\n.\tO\n\nSeizures\tB-Disease\ndisappeared\tO\nin\tO\n71\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\nwith\tO\ngeneralized\tO\nseizures\tB-Disease\nand\tO\n89\tO\n%\tO\nof\tO\npartial\tO\nseizures\tB-Disease\n.\tO\n\nImprovement\tO\nof\tO\nabnormal\tO\nEEG\tO\nwas\tO\nnoticed\tO\nin\tO\n76\tO\n%\tO\nof\tO\ndiffuse\tO\nparoxysms\tO\nand\tO\nin\tO\n67\tO\n%\tO\nof\tO\nfocal\tO\nparoxysms\tO\n.\tO\n\nIn\tO\nexcellent\tO\ncases\tO\n,\tO\nmean\tO\neffective\tO\ndosages\tO\nwere\tO\n0\tO\n.\tO\n086\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n021\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nin\tO\ninfants\tO\nand\tO\n0\tO\n.\tO\n057\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n022\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nin\tO\nschoolchildren\tO\n,\tO\nthis\tO\ndifference\tO\nwas\tO\nstatistically\tO\nsignificant\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n005\tO\n)\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nside\tO\neffects\tO\nsuch\tO\nas\tO\ndrowsiness\tB-Disease\nand\tO\nataxia\tB-Disease\nwas\tO\nonly\tO\n5\tO\n%\tO\n.\tO\n\nPostmarketing\tO\nstudy\tO\nof\tO\ntimolol\tB-Chemical\n-\tO\nhydrochlorothiazide\tB-Chemical\nantihypertensive\tO\ntherapy\tO\n.\tO\n\nA\tO\npostmarketing\tO\nsurveillance\tO\nstudy\tO\nwas\tO\nconducted\tO\nto\tO\ndetermine\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\na\tO\nfixed\tO\n-\tO\nratio\tO\ncombination\tO\ncontaining\tO\n10\tO\nmg\tO\nof\tO\ntimolol\tB-Chemical\nmaleate\tI-Chemical\nand\tO\n25\tO\nmg\tO\nof\tO\nhydrochlorothiazide\tB-Chemical\n,\tO\nadministered\tO\ntwice\tO\ndaily\tO\nfor\tO\none\tO\nmonth\tO\nto\tO\nhypertensive\tB-Disease\npatients\tO\n.\tO\n\nData\tO\non\tO\n9\tO\n,\tO\n037\tO\npatients\tO\nwere\tO\ncollected\tO\nby\tO\n1\tO\n,\tO\n455\tO\nparticipating\tO\nphysicians\tO\n.\tO\n\nMean\tO\nsystolic\tO\nblood\tO\npressure\tO\ndecreased\tO\n25\tO\nmmHg\tO\nand\tO\nmean\tO\ndiastolic\tO\nblood\tO\npressure\tO\ndeclined\tO\n15\tO\nmmHg\tO\nafter\tO\none\tO\nmonth\tO\nof\tO\ntimolol\tB-Chemical\n-\tO\nhydrochlorothiazide\tB-Chemical\ntherapy\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n,\tO\nboth\tO\ncomparisons\tO\n)\tO\n.\tO\n\nAge\tO\n,\tO\nrace\tO\n,\tO\nand\tO\nsex\tO\nappeared\tO\nto\tO\nhave\tO\nno\tO\ninfluence\tO\non\tO\nthe\tO\ndecrease\tO\nin\tO\nblood\tO\npressure\tO\n.\tO\n\nThe\tO\nantihypertensive\tO\neffect\tO\nof\tO\nthe\tO\ndrug\tO\nwas\tO\ngreater\tO\nin\tO\npatients\tO\nwith\tO\nmore\tO\nsevere\tO\nhypertension\tB-Disease\n.\tO\n\nOverall\tO\n,\tO\n1\tO\n,\tO\n453\tO\npatients\tO\nexperienced\tO\na\tO\ntotal\tO\nof\tO\n2\tO\n,\tO\n658\tO\nadverse\tO\nevents\tO\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nbeing\tO\nfatigue\tB-Disease\n,\tO\ndizziness\tB-Disease\n,\tO\nand\tO\nweakness\tB-Disease\n.\tO\n\nTreatment\tO\nin\tO\n590\tO\npatients\tO\nwas\tO\ndiscontinued\tO\nbecause\tO\nof\tO\nadverse\tO\nevents\tO\n.\tO\n\nSalicylate\tB-Chemical\nnephropathy\tB-Disease\nin\tO\nthe\tO\nGunn\tO\nrat\tO\n:\tO\npotential\tO\nrole\tO\nof\tO\nprostaglandins\tB-Chemical\n.\tO\n\nWe\tO\nexamined\tO\nthe\tO\npotential\tO\nrole\tO\nof\tO\nprostaglandins\tB-Chemical\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nanalgesic\tO\nnephropathy\tB-Disease\nin\tO\nthe\tO\nGunn\tO\nstrain\tO\nof\tO\nrat\tO\n.\tO\n\nThe\tO\nhomozygous\tO\nGunn\tO\nrats\tO\nhave\tO\nunconjugated\tO\nhyperbilirubinemia\tB-Disease\ndue\tO\nto\tO\nthe\tO\nabsence\tO\nof\tO\nglucuronyl\tB-Chemical\ntransferase\tO\n,\tO\nleading\tO\nto\tO\nmarked\tO\nbilirubin\tB-Chemical\ndeposition\tO\nin\tO\nrenal\tO\nmedulla\tO\nand\tO\npapilla\tO\n.\tO\n\nThese\tO\nrats\tO\nare\tO\nalso\tO\nhighly\tO\nsusceptible\tO\nto\tO\ndevelop\tO\npapillary\tB-Disease\nnecrosis\tI-Disease\nwith\tO\nanalgesic\tO\nadministration\tO\n.\tO\n\nWe\tO\nused\tO\nhomozygous\tO\n(\tO\njj\tO\n)\tO\nand\tO\nphenotypically\tO\nnormal\tO\nheterozygous\tO\n(\tO\njJ\tO\n)\tO\nanimals\tO\n.\tO\n\nFour\tO\ngroups\tO\nof\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n7\tO\n)\tO\nwere\tO\nstudied\tO\n:\tO\njj\tO\nand\tO\njJ\tO\nrats\tO\ntreated\tO\neither\tO\nwith\tO\naspirin\tB-Chemical\n300\tO\nmg\tO\n/\tO\nkg\tO\nevery\tO\nother\tO\nday\tO\nor\tO\nsham\tO\n-\tO\ntreated\tO\n.\tO\n\nAfter\tO\none\tO\nweek\tO\n,\tO\nslices\tO\nof\tO\ncortex\tO\n,\tO\nouter\tO\nand\tO\ninner\tO\nmedulla\tO\nfrom\tO\none\tO\nkidney\tO\nwere\tO\nincubated\tO\nin\tO\nbuffer\tO\nand\tO\nprostaglandin\tB-Chemical\nsynthesis\tO\nwas\tO\ndetermined\tO\nby\tO\nradioimmunoassay\tO\n.\tO\n\nThe\tO\nother\tO\nkidney\tO\nwas\tO\nexamined\tO\nhistologically\tO\n.\tO\n\nA\tO\nmarked\tO\ncorticomedullary\tO\ngradient\tO\nof\tO\nprostaglandin\tB-Chemical\nsynthesis\tO\nwas\tO\nobserved\tO\nin\tO\nall\tO\ngroups\tO\n.\tO\n\nPGE2\tB-Chemical\nsynthesis\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nin\tO\nouter\tO\nmedulla\tO\n,\tO\nbut\tO\nnot\tO\ncortex\tO\nor\tO\ninner\tO\nmedulla\tO\n,\tO\nof\tO\njj\tO\n(\tO\n38\tO\n+\tO\n/\tO\n-\tO\n6\tO\nng\tO\n/\tO\nmg\tO\nprot\tO\n)\tO\nthan\tO\njJ\tO\nrats\tO\n(\tO\n15\tO\n+\tO\n/\tO\n-\tO\n3\tO\n)\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nAspirin\tB-Chemical\ntreatment\tO\nreduced\tO\nPGE2\tB-Chemical\nsynthesis\tO\nin\tO\nall\tO\nregions\tO\n,\tO\nbut\tO\nouter\tO\nmedullary\tO\nPGE2\tB-Chemical\nremained\tO\nhigher\tO\nin\tO\njj\tO\n(\tO\n18\tO\n+\tO\n/\tO\n-\tO\n3\tO\n)\tO\nthan\tO\njJ\tO\nrats\tO\n(\tO\n9\tO\n+\tO\n/\tO\n-\tO\n2\tO\n)\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nPGF2\tB-Chemical\nalpha\tI-Chemical\nwas\tO\nalso\tO\nsignificantly\tO\nhigher\tO\nin\tO\nthe\tO\nouter\tO\nmedulla\tO\nof\tO\njj\tO\nrats\tO\nwith\tO\nand\tO\nwithout\tO\naspirin\tB-Chemical\nadministration\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\nchanges\tO\nin\tO\nrenal\tO\nprostaglandin\tB-Chemical\nsynthesis\tO\nwere\tO\naccompanied\tO\nby\tO\nevidence\tO\nof\tO\nrenal\tB-Disease\ndamage\tI-Disease\nin\tO\naspirin\tB-Chemical\n-\tO\ntreated\tO\njj\tO\nbut\tO\nnot\tO\njJ\tO\nrats\tO\nas\tO\nevidenced\tO\nby\tO\n:\tO\nincreased\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nhematuria\tB-Disease\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n;\tO\nincreased\tO\nserum\tO\ncreatinine\tB-Chemical\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n;\tO\nand\tO\nincrease\tO\nin\tO\nouter\tO\nmedullary\tO\nhistopathologic\tO\nlesions\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n005\tO\ncompared\tO\nto\tO\neither\tO\nsham\tO\n-\tO\ntreated\tO\njj\tO\nor\tO\naspirin\tB-Chemical\n-\tO\ntreated\tO\njJ\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nenhanced\tO\nprostaglandin\tB-Chemical\nsynthesis\tO\ncontributes\tO\nto\tO\nmaintenance\tO\nof\tO\nrenal\tO\nfunction\tO\nand\tO\nmorphological\tO\nintegrity\tO\n,\tO\nand\tO\nthat\tO\ninhibition\tO\nof\tO\nprostaglandin\tB-Chemical\nsynthesis\tO\nmay\tO\nlead\tO\nto\tO\npathological\tB-Disease\nrenal\tI-Disease\nmedullary\tI-Disease\nlesions\tI-Disease\nand\tO\ndeterioration\tB-Disease\nof\tI-Disease\nrenal\tI-Disease\nfunction\tI-Disease\n.\tO\n\nProphylactic\tO\nlidocaine\tB-Chemical\nin\tO\nthe\tO\nearly\tO\nphase\tO\nof\tO\nsuspected\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nFour\tO\nhundred\tO\ntwo\tO\npatients\tO\nwith\tO\nsuspected\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nseen\tO\nwithin\tO\n6\tO\nhours\tO\nof\tO\nthe\tO\nonset\tO\nof\tO\nsymptoms\tO\nentered\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\nrandomized\tO\ntrial\tO\nof\tO\nlidocaine\tB-Chemical\nvs\tO\nplacebo\tO\n.\tO\n\nDuring\tO\nthe\tO\n1\tO\nhour\tO\nafter\tO\nadministration\tO\nof\tO\nthe\tO\ndrug\tO\nthe\tO\nincidence\tO\nof\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nor\tO\nsustained\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\namong\tO\nthe\tO\n204\tO\npatients\tO\nwith\tO\nacute\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nlow\tO\n,\tO\n1\tO\n.\tO\n5\tO\n%\tO\n.\tO\n\nLidocaine\tB-Chemical\n,\tO\ngiven\tO\nin\tO\na\tO\n300\tO\nmg\tO\ndose\tO\nintramuscularly\tO\nfollowed\tO\nby\tO\n100\tO\nmg\tO\nintravenously\tO\n,\tO\ndid\tO\nnot\tO\nprevent\tO\nsustained\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n,\tO\nalthough\tO\nthere\tO\nwas\tO\na\tO\nsignificant\tO\nreduction\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\npatients\tO\nwith\tO\nwarning\tO\narrhythmias\tB-Disease\nbetween\tO\n15\tO\nand\tO\n45\tO\nminutes\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\nlidocaine\tB-Chemical\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\naverage\tO\nplasma\tO\nlidocaine\tB-Chemical\nlevel\tO\n10\tO\nminutes\tO\nafter\tO\nadministration\tO\nfor\tO\npatients\tO\nwithout\tO\na\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nsignificantly\tO\nhigher\tO\nthan\tO\nthat\tO\nfor\tO\npatients\tO\nwith\tO\nan\tO\nacute\tO\ninfarction\tB-Disease\n.\tO\n\nThe\tO\nmean\tO\nplasma\tO\nlidocaine\tB-Chemical\nlevel\tO\nof\tO\npatients\tO\non\tO\nbeta\tO\n-\tO\nblocking\tO\nagents\tO\nwas\tO\nno\tO\ndifferent\tO\nfrom\tO\nthat\tO\nin\tO\npatients\tO\nnot\tO\non\tO\nbeta\tO\nblocking\tO\nagents\tO\n.\tO\n\nDuring\tO\nthe\tO\n1\tO\n-\tO\nhour\tO\nstudy\tO\nperiod\tO\n,\tO\nthe\tO\nincidence\tO\nof\tO\ncentral\tO\nnervous\tO\nsystem\tO\nside\tO\neffects\tO\nwas\tO\nsignificantly\tO\ngreater\tO\nin\tO\nthe\tO\nlidocaine\tB-Chemical\ngroup\tO\n,\tO\nhypotension\tB-Disease\noccurred\tO\nin\tO\n11\tO\npatients\tO\n,\tO\nnine\tO\nof\tO\nwhom\tO\nhad\tO\nreceived\tO\nlidocaine\tB-Chemical\n,\tO\nand\tO\nfour\tO\npatients\tO\ndied\tO\nfrom\tO\nasystole\tB-Disease\n,\tO\nthree\tO\nof\tO\nwhom\tO\nhad\tO\nhad\tO\nlidocaine\tB-Chemical\n.\tO\n\nWe\tO\ncannot\tO\nadvocate\tO\nthe\tO\nadministration\tO\nof\tO\nlidocaine\tB-Chemical\nprophylactically\tO\nin\tO\nthe\tO\nearly\tO\nhours\tO\nof\tO\nsuspected\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nEvidence\tO\nfor\tO\na\tO\ncholinergic\tO\nrole\tO\nin\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n.\tO\n\nExperiments\tO\nin\tO\nmice\tO\ntested\tO\nprevious\tO\nevidence\tO\nthat\tO\nactivation\tO\nof\tO\ncholinergic\tO\nsystems\tO\npromotes\tO\ncatalepsy\tB-Disease\nand\tO\nthat\tO\ncholinergic\tO\nmechanisms\tO\nneed\tO\nto\tO\nbe\tO\nintact\tO\nfor\tO\nfull\tO\nexpression\tO\nof\tO\nneuroleptic\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n.\tO\n\nLarge\tO\ndoses\tO\nof\tO\nthe\tO\ncholinomimetic\tO\n,\tO\npilocarpine\tB-Chemical\n,\tO\ncould\tO\ninduce\tO\ncatalepsy\tB-Disease\nwhen\tO\nperipheral\tO\ncholinergic\tO\nreceptors\tO\nwere\tO\nblocked\tO\n.\tO\n\nLow\tO\ndoses\tO\nof\tO\npilocarpine\tB-Chemical\ncaused\tO\na\tO\npronounced\tO\nenhancement\tO\nof\tO\nthe\tO\ncatalepsy\tB-Disease\nthat\tO\nwas\tO\ninduced\tO\nby\tO\nthe\tO\ndopaminergic\tO\nblocker\tO\n,\tO\nhaloperidol\tB-Chemical\n.\tO\n\nA\tO\nmuscarinic\tO\nreceptor\tO\nblocker\tO\n,\tO\natropine\tB-Chemical\n,\tO\ndisrupted\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n.\tO\n\nIntracranial\tO\ninjection\tO\nof\tO\nan\tO\nacetylcholine\tB-Chemical\n-\tO\nsynthesis\tO\ninhibitor\tO\n,\tO\nhemicholinium\tB-Chemical\n,\tO\nprevented\tO\nthe\tO\ncatalepsy\tB-Disease\nthat\tO\nis\tO\nusually\tO\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\ncatalepsy\tB-Disease\nthat\tO\nis\tO\nproduced\tO\nby\tO\nneuroleptics\tB-Chemical\nsuch\tO\nas\tO\nhaloperidol\tB-Chemical\nis\tO\nactually\tO\nmediated\tO\nby\tO\nintrinsic\tO\ncentral\tO\ncholinergic\tO\nsystems\tO\n.\tO\n\nAlternatively\tO\n,\tO\nactivation\tO\nof\tO\ncentral\tO\ncholinergic\tO\nsystems\tO\ncould\tO\npromote\tO\ncatalepsy\tB-Disease\nby\tO\nsuppression\tO\nof\tO\ndopaminergic\tO\nsystems\tO\n.\tO\n\nCardiovascular\tB-Disease\ndysfunction\tI-Disease\nand\tO\nhypersensitivity\tB-Disease\nto\tO\nsodium\tB-Chemical\npentobarbital\tI-Chemical\ninduced\tO\nby\tO\nchronic\tO\nbarium\tB-Chemical\nchloride\tI-Chemical\ningestion\tO\n.\tO\n\nBarium\tB-Chemical\n-\tO\nsupplemented\tO\nLong\tO\n-\tO\nEvans\tO\nhooded\tO\nrats\tO\nwere\tO\ncharacterized\tO\nby\tO\na\tO\npersistent\tO\nhypertension\tB-Disease\nthat\tO\nwas\tO\nevident\tO\nafter\tO\n1\tO\nmonth\tO\nof\tO\nbarium\tB-Chemical\n(\tO\n100\tO\nmicrograms\tO\n/\tO\nml\tO\nmineral\tO\nfortified\tO\nwater\tO\n)\tO\ntreatment\tO\n.\tO\n\nAnalysis\tO\nof\tO\nin\tO\nvivo\tO\nmyocardial\tO\nexcitability\tO\n,\tO\ncontractility\tO\n,\tO\nand\tO\nmetabolic\tO\ncharacteristics\tO\nat\tO\n16\tO\nmonths\tO\nrevealed\tO\nother\tO\nsignificant\tO\nbarium\tB-Chemical\n-\tO\ninduced\tO\ndisturbances\tB-Disease\nwithin\tI-Disease\nthe\tI-Disease\ncardiovascular\tI-Disease\nsystem\tI-Disease\n.\tO\n\nThe\tO\nmost\tO\ndistinctive\tO\naspect\tO\nof\tO\nthe\tO\nbarium\tB-Chemical\neffect\tO\nwas\tO\na\tO\ndemonstrated\tO\nhypersensitivity\tB-Disease\nof\tO\nthe\tO\ncardiovascular\tO\nsystem\tO\nto\tO\nsodium\tB-Chemical\npentobarbital\tI-Chemical\n.\tO\n\nUnder\tO\nbarbiturate\tB-Chemical\nanesthesia\tO\n,\tO\nvirtually\tO\nall\tO\nof\tO\nthe\tO\nmyocardial\tO\ncontractile\tO\nindices\tO\nwere\tO\ndepressed\tO\nsignificantly\tO\nin\tO\nbarium\tB-Chemical\n-\tO\nexposed\tO\nrats\tO\nrelative\tO\nto\tO\nthe\tO\ncorresponding\tO\ncontrol\tO\n-\tO\nfed\tO\nrats\tO\n.\tO\n\nThe\tO\nlack\tO\nof\tO\na\tO\nsimilar\tO\nresponse\tO\nto\tO\nketamine\tB-Chemical\nand\tO\nxylazine\tB-Chemical\nanesthesia\tO\nrevealed\tO\nthat\tO\nthe\tO\ncardiovascular\tO\nactions\tO\nof\tO\nsodium\tB-Chemical\npentobarbital\tI-Chemical\nin\tO\nbarium\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nwere\tO\nlinked\tO\nspecifically\tO\nto\tO\nthis\tO\nanesthetic\tO\n,\tO\nand\tO\nwere\tO\nnot\tO\nrepresentative\tO\nof\tO\na\tO\ngeneralized\tO\nanesthetic\tO\nresponse\tO\n.\tO\n\nOther\tO\nmyocardial\tO\npathophysiologic\tO\nand\tO\nmetabolic\tO\nchanges\tO\ninduced\tO\nby\tO\nbarium\tB-Chemical\nwere\tO\nmanifest\tO\n,\tO\nirrespective\tO\nof\tO\nthe\tO\nanesthetic\tO\nemployed\tO\n.\tO\n\nThe\tO\ncontractile\tO\nelement\tO\nshortening\tO\nvelocity\tO\nof\tO\nthe\tO\ncardiac\tO\nmuscle\tO\nfibers\tO\nwas\tO\nsignificantly\tO\nslower\tO\nin\tO\nboth\tO\ngroups\tO\nof\tO\nbarium\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nrelative\tO\nto\tO\nthe\tO\ncontrol\tO\ngroups\tO\n,\tO\nirrespective\tO\nof\tO\nthe\tO\nanesthetic\tO\nregimen\tO\n.\tO\n\nSimilarly\tO\n,\tO\nsignificant\tO\ndisturbances\tO\nin\tO\nmyocardial\tO\nenergy\tO\nmetabolism\tO\nwere\tO\ndetected\tO\nin\tO\nthe\tO\nbarium\tB-Chemical\n-\tO\nexposed\tO\nrats\tO\nwhich\tO\nwere\tO\nconsistent\tO\nwith\tO\nthe\tO\nreduced\tO\ncontractile\tO\nelement\tO\nshortening\tO\nvelocity\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthe\tO\nexcitability\tO\nof\tO\nthe\tO\ncardiac\tO\nconduction\tO\nsystem\tO\nwas\tO\ndepressed\tO\npreferentially\tO\nin\tO\nthe\tO\natrioventricular\tO\nnodal\tO\nregion\tO\nof\tO\nhearts\tO\nfrom\tO\nbarium\tB-Chemical\n-\tO\nexposed\tO\nrats\tO\n.\tO\n\nOverall\tO\n,\tO\nthe\tO\naltered\tO\ncardiac\tO\ncontractility\tO\nand\tO\nexcitability\tO\ncharacteristics\tO\n,\tO\nthe\tO\nmyocardial\tO\nmetabolic\tB-Disease\ndisturbances\tI-Disease\n,\tO\nand\tO\nthe\tO\nhypersensitivity\tB-Disease\nof\tO\nthe\tO\ncardiovascular\tO\nsystem\tO\nto\tO\nsodium\tB-Chemical\npentobarbital\tI-Chemical\nsuggest\tO\nthe\tO\nexistence\tO\nof\tO\na\tO\nheretofore\tO\nundescribed\tO\ncardiomyopathic\tB-Disease\ndisorder\tI-Disease\ninduced\tO\nby\tO\nchronic\tO\nbarium\tB-Chemical\nexposure\tO\n.\tO\n\nThese\tO\nexperimental\tO\nfindings\tO\nrepresent\tO\nthe\tO\nfirst\tO\nindication\tO\nthat\tO\nlife\tO\n-\tO\nlong\tO\nbarium\tB-Chemical\ningestion\tO\nmay\tO\nhave\tO\nsignificant\tO\nadverse\tO\neffects\tO\non\tO\nthe\tO\nmammalian\tO\ncardiovascular\tO\nsystem\tO\n.\tO\n\nPropranolol\tB-Chemical\nantagonism\tO\nof\tO\nphenylpropanolamine\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n.\tO\n\nPhenylpropanolamine\tB-Chemical\n(\tO\nPPA\tB-Chemical\n)\tO\noverdose\tB-Disease\ncan\tO\ncause\tO\nsevere\tO\nhypertension\tB-Disease\n,\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n,\tO\nand\tO\ndeath\tO\n.\tO\n\nWe\tO\nstudied\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\npropranolol\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nPPA\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n.\tO\n\nSubjects\tO\nreceived\tO\npropranolol\tB-Chemical\neither\tO\nby\tO\nmouth\tO\nfor\tO\n48\tO\nhours\tO\nbefore\tO\nPPA\tB-Chemical\nor\tO\nas\tO\na\tO\nrapid\tO\nintravenous\tO\ninfusion\tO\nafter\tO\nPPA\tB-Chemical\n.\tO\n\nPPA\tB-Chemical\n,\tO\n75\tO\nmg\tO\nalone\tO\n,\tO\nincreased\tO\nblood\tO\npressure\tO\n(\tO\n31\tO\n+\tO\n/\tO\n-\tO\n14\tO\nmm\tO\nHg\tO\nsystolic\tO\n,\tO\n20\tO\n+\tO\n/\tO\n-\tO\n5\tO\nmm\tO\nHg\tO\ndiastolic\tO\n)\tO\n,\tO\nand\tO\npropranolol\tB-Chemical\npretreatment\tO\nantagonized\tO\nthis\tO\nincrease\tO\n(\tO\n12\tO\n+\tO\n/\tO\n-\tO\n10\tO\nmm\tO\nHg\tO\nsystolic\tO\n,\tO\n10\tO\n+\tO\n/\tO\n-\tO\n7\tO\nmm\tO\nHg\tO\ndiastolic\tO\n)\tO\n.\tO\n\nIntravenous\tO\npropranolol\tB-Chemical\nafter\tO\nPPA\tB-Chemical\nalso\tO\ndecreased\tO\nblood\tO\npressure\tO\n.\tO\n\nLeft\tO\nventricular\tO\nfunction\tO\n(\tO\nassessed\tO\nby\tO\nechocardiography\tO\n)\tO\nshowed\tO\nthat\tO\nPPA\tB-Chemical\nincreased\tO\nthe\tO\nstroke\tB-Disease\nvolume\tO\n30\tO\n%\tO\n(\tO\nfrom\tO\n62\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n20\tO\n.\tO\n9\tO\nto\tO\n80\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n22\tO\n.\tO\n4\tO\nml\tO\n)\tO\n,\tO\nthe\tO\nejection\tO\nfraction\tO\n9\tO\n%\tO\n(\tO\nfrom\tO\n64\tO\n%\tO\n+\tO\n/\tO\n-\tO\n10\tO\n%\tO\nto\tO\n70\tO\n%\tO\n+\tO\n/\tO\n-\tO\n7\tO\n%\tO\n)\tO\n,\tO\nand\tO\ncardiac\tO\noutput\tO\n14\tO\n%\tO\n(\tO\nfrom\tO\n3\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n6\tO\nto\tO\n4\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n0\tO\nL\tO\n/\tO\nmin\tO\n)\tO\n.\tO\n\nIntravenous\tO\npropranolol\tB-Chemical\nreversed\tO\nthese\tO\neffects\tO\n.\tO\n\nSystemic\tO\nvascular\tO\nresistance\tO\nwas\tO\nincreased\tO\nby\tO\nPPA\tB-Chemical\n28\tO\n%\tO\n(\tO\nfrom\tO\n1710\tO\n+\tO\n/\tO\n-\tO\n200\tO\nto\tO\n2190\tO\n+\tO\n/\tO\n-\tO\n700\tO\ndyne\tO\nX\tO\nsec\tO\n/\tO\ncm5\tO\n)\tO\nand\tO\nwas\tO\nfurther\tO\nincreased\tO\nby\tO\npropranolol\tB-Chemical\n22\tO\n%\tO\n(\tO\nto\tO\n2660\tO\n+\tO\n/\tO\n-\tO\n1200\tO\ndyne\tO\nX\tO\nsec\tO\n/\tO\ncm5\tO\n)\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nPPA\tB-Chemical\nincreases\tO\nblood\tO\npressure\tO\nby\tO\nincreasing\tO\nsystemic\tO\nvascular\tO\nresistance\tO\nand\tO\ncardiac\tO\noutput\tO\n,\tO\nand\tO\nthat\tO\npropranolol\tB-Chemical\nantagonizes\tO\nthis\tO\nincrease\tO\nby\tO\nreversing\tO\nthe\tO\neffect\tO\nof\tO\nPPA\tB-Chemical\non\tO\ncardiac\tO\noutput\tO\n.\tO\n\nThat\tO\npropranolol\tB-Chemical\nantagonizes\tO\nthe\tO\npressor\tO\neffect\tO\nof\tO\nPPA\tB-Chemical\nis\tO\nin\tO\ncontrast\tO\nto\tO\nthe\tO\ninteraction\tO\nin\tO\nwhich\tO\npropranolol\tB-Chemical\nenhances\tO\nthe\tO\npressor\tO\neffect\tO\nof\tO\nnorepinephrine\tB-Chemical\n.\tO\n\nThis\tO\nis\tO\nprobably\tO\nbecause\tO\nPPA\tB-Chemical\nhas\tO\nless\tO\nbeta\tO\n2\tO\nactivity\tO\nthan\tO\ndoes\tO\nnorepinephrine\tB-Chemical\n.\tO\n\nMesangial\tO\nfunction\tO\nand\tO\nglomerular\tB-Disease\nsclerosis\tI-Disease\nin\tO\nrats\tO\nwith\tO\naminonucleoside\tB-Chemical\nnephrosis\tB-Disease\n.\tO\n\nThe\tO\npossible\tO\nrelationship\tO\nbetween\tO\nmesangial\tB-Disease\ndysfunction\tI-Disease\nand\tO\ndevelopment\tO\nof\tO\nglomerular\tB-Disease\nsclerosis\tI-Disease\nwas\tO\nstudied\tO\nin\tO\nthe\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n)\tO\nmodel\tO\n.\tO\n\nFive\tO\nmale\tO\nWistar\tO\nrats\tO\nreceived\tO\nrepeated\tO\nsubcutaneous\tO\nPAN\tB-Chemical\ninjections\tO\n;\tO\nfive\tO\ncontrols\tO\nreceived\tO\nsaline\tO\nonly\tO\n.\tO\n\nAfter\tO\n4\tO\nweeks\tO\nthe\tO\nPAN\tB-Chemical\nrats\tO\nwere\tO\nseverely\tO\nproteinuric\tB-Disease\n(\tO\n190\tO\n+\tO\n/\tO\n-\tO\n80\tO\nmg\tO\n/\tO\n24\tO\nhr\tO\n)\tO\n,\tO\nand\tO\nall\tO\nrats\tO\nwere\tO\ngiven\tO\ncolloidal\tO\ncarbon\tB-Chemical\n(\tO\nCC\tO\n)\tO\nintravenously\tO\n.\tO\n\nAt\tO\n5\tO\nmonths\tO\nglomerular\tB-Disease\nsclerosis\tI-Disease\nwas\tO\nfound\tO\nin\tO\n7\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n4\tO\n%\tO\nof\tO\nthe\tO\nglomeruli\tO\nof\tO\nPAN\tB-Chemical\nrats\tO\n;\tO\nglomeruli\tO\nof\tO\nthe\tO\ncontrols\tO\nwere\tO\nnormal\tO\n.\tO\n\nGlomeruli\tO\nof\tO\nPAN\tB-Chemical\nrats\tO\ncontained\tO\nsignificantly\tO\nmore\tO\nCC\tO\nthan\tO\nglomeruli\tO\nof\tO\ncontrols\tO\n.\tO\n\nGlomeruli\tO\nwith\tO\nsclerosis\tB-Disease\ncontained\tO\nsignificantly\tO\nmore\tO\nCC\tO\nthan\tO\nnon\tO\n-\tO\nsclerotic\tO\nglomeruli\tO\nin\tO\nthe\tO\nsame\tO\nkidneys\tO\n.\tO\n\nCC\tO\nwas\tO\npreferentially\tO\nlocalized\tO\nwithin\tO\nthe\tO\nsclerotic\tO\nareas\tO\nof\tO\nthe\tO\naffected\tO\nglomeruli\tO\n.\tO\n\nSince\tO\nmesangial\tO\nCC\tO\nclearance\tO\nfrom\tO\nthe\tO\nmesangium\tO\ndid\tO\nnot\tO\nchange\tO\nduring\tO\nchronic\tO\nPAN\tB-Chemical\ntreatment\tO\n,\tO\nwe\tO\nconclude\tO\nthat\tO\nthis\tO\npreferential\tO\nCC\tO\nlocalization\tO\nwithin\tO\nthe\tO\nlesions\tO\nis\tO\ncaused\tO\nby\tO\nan\tO\nincreased\tO\nCC\tO\nuptake\tO\nshortly\tO\nafter\tO\ninjection\tO\nin\tO\napparent\tO\nvulnerable\tO\nareas\tO\nwhere\tO\nsclerosis\tB-Disease\nwill\tO\ndevelop\tO\nsubsequently\tO\n.\tO\n\nCluster\tO\nanalysis\tO\nshowed\tO\na\tO\nrandom\tO\ndistribution\tO\nof\tO\nlesions\tO\nin\tO\nthe\tO\nPAN\tB-Chemical\nglomeruli\tO\nin\tO\nconcordance\tO\nwith\tO\nthe\tO\nrandom\tO\nlocalization\tO\nof\tO\nmesangial\tO\nareas\tO\nwith\tO\ndysfunction\tO\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nSimilar\tO\nto\tO\nthe\tO\nremnant\tO\nkidney\tO\nmodel\tO\nin\tO\nPAN\tB-Chemical\nnephrosis\tB-Disease\nthe\tO\ndevelopment\tO\nof\tO\nglomerular\tB-Disease\nsclerosis\tI-Disease\nmay\tO\nbe\tO\nrelated\tO\nto\tO\n\"\tO\nmesangial\tO\noverloading\tO\n.\tO\n\"\tO\n\nRelationship\tO\nbetween\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nhippocampal\tO\nnicotinic\tO\nreceptors\tO\n.\tO\n\nA\tO\ncontroversy\tO\nhas\tO\nexisted\tO\nfor\tO\nseveral\tO\nyears\tO\nconcerning\tO\nthe\tO\nphysiological\tO\nrelevance\tO\nof\tO\nthe\tO\nnicotinic\tO\nreceptor\tO\nmeasured\tO\nby\tO\nalpha\tO\n-\tO\nbungarotoxin\tO\nbinding\tO\n.\tO\n\nUsing\tO\nmice\tO\nderived\tO\nfrom\tO\na\tO\nclassical\tO\nF2\tO\nand\tO\nbackcross\tO\ngenetic\tO\ndesign\tO\n,\tO\na\tO\nrelationship\tO\nbetween\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nalpha\tO\n-\tO\nbungarotoxin\tO\nnicotinic\tO\nreceptor\tO\nconcentration\tO\nwas\tO\nfound\tO\n.\tO\n\nMice\tO\nsensitive\tO\nto\tO\nthe\tO\nconvulsant\tO\neffects\tO\nof\tO\nnicotine\tB-Chemical\nhad\tO\ngreater\tO\nalpha\tO\n-\tO\nbungarotoxin\tO\nbinding\tO\nin\tO\nthe\tO\nhippocampus\tO\nthan\tO\nseizure\tB-Disease\ninsensitive\tO\nmice\tO\n.\tO\n\nThe\tO\nbinding\tO\nsites\tO\nfrom\tO\nseizure\tB-Disease\nsensitive\tO\nand\tO\nresistant\tO\nmice\tO\nwere\tO\nequally\tO\naffected\tO\nby\tO\ntreatment\tO\nwith\tO\ndithiothreitol\tB-Chemical\n,\tO\ntrypsin\tO\nor\tO\nheat\tO\n.\tO\n\nThus\tO\nit\tO\nappears\tO\nthat\tO\nthe\tO\ndifference\tO\nbetween\tO\nseizure\tB-Disease\nsensitive\tO\nand\tO\ninsensitive\tO\nanimals\tO\nmay\tO\nbe\tO\ndue\tO\nto\tO\na\tO\ndifference\tO\nin\tO\nhippocampal\tO\nnicotinic\tO\nreceptor\tO\nconcentration\tO\nas\tO\nmeasured\tO\nwith\tO\nalpha\tO\n-\tO\nbungarotoxin\tO\nbinding\tO\n.\tO\n\nThe\tO\nrole\tO\nof\tO\np\tB-Chemical\n-\tI-Chemical\naminophenol\tI-Chemical\nin\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n:\tO\neffect\tO\nof\tO\nbis\tB-Chemical\n(\tI-Chemical\np\tI-Chemical\n-\tI-Chemical\nnitrophenyl\tI-Chemical\n)\tI-Chemical\nphosphate\tI-Chemical\non\tO\nacetaminophen\tB-Chemical\nand\tO\np\tB-Chemical\n-\tI-Chemical\naminophenol\tI-Chemical\nnephrotoxicity\tB-Disease\nand\tO\nmetabolism\tO\nin\tO\nFischer\tO\n344\tO\nrats\tO\n.\tO\n\nAcetaminophen\tB-Chemical\n(\tO\nAPAP\tB-Chemical\n)\tO\nproduces\tO\nproximal\tO\ntubular\tB-Disease\nnecrosis\tI-Disease\nin\tO\nFischer\tO\n344\tO\n(\tO\nF344\tO\n)\tO\nrats\tO\n.\tO\n\nRecently\tO\n,\tO\np\tB-Chemical\n-\tI-Chemical\naminophenol\tI-Chemical\n(\tO\nPAP\tB-Chemical\n)\tO\n,\tO\na\tO\nknown\tO\npotent\tO\nnephrotoxicant\tO\n,\tO\nwas\tO\nidentified\tO\nas\tO\na\tO\nmetabolite\tO\nof\tO\nAPAP\tB-Chemical\nin\tO\nF344\tO\nrats\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nif\tO\nPAP\tB-Chemical\nformation\tO\nis\tO\na\tO\nrequisite\tO\nstep\tO\nin\tO\nAPAP\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nTherefore\tO\n,\tO\nthe\tO\neffect\tO\nof\tO\nbis\tB-Chemical\n(\tI-Chemical\np\tI-Chemical\n-\tI-Chemical\nnitrophenyl\tI-Chemical\n)\tI-Chemical\nphosphate\tI-Chemical\n(\tO\nBNPP\tB-Chemical\n)\tO\n,\tO\nan\tO\nacylamidase\tO\ninhibitor\tO\n,\tO\non\tO\nAPAP\tB-Chemical\nand\tO\nPAP\tB-Chemical\nnephrotoxicity\tB-Disease\nand\tO\nmetabolism\tO\nwas\tO\ndetermined\tO\n.\tO\n\nBNPP\tB-Chemical\n(\tO\n1\tO\nto\tO\n8\tO\nmM\tO\n)\tO\nreduced\tO\nAPAP\tB-Chemical\ndeacetylation\tO\nand\tO\ncovalent\tO\nbinding\tO\nin\tO\nF344\tO\nrenal\tO\ncortical\tO\nhomogenates\tO\nin\tO\na\tO\nconcentration\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nPretreatment\tO\nof\tO\nanimals\tO\nwith\tO\nBNPP\tB-Chemical\nprior\tO\nto\tO\nAPAP\tB-Chemical\nor\tO\nPAP\tB-Chemical\nadministration\tO\nresulted\tO\nin\tO\nmarked\tO\nreduction\tO\nof\tO\nAPAP\tB-Chemical\n(\tO\n900\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nnephrotoxicity\tB-Disease\nbut\tO\nnot\tO\nPAP\tB-Chemical\nnephrotoxicity\tB-Disease\n.\tO\n\nThis\tO\nresult\tO\nwas\tO\nnot\tO\ndue\tO\nto\tO\naltered\tO\ndisposition\tO\nof\tO\neither\tO\nAPAP\tB-Chemical\nor\tO\nacetylated\tO\nmetabolites\tO\nin\tO\nplasma\tO\nor\tO\nrenal\tO\ncortical\tO\nand\tO\nhepatic\tO\ntissue\tO\n.\tO\n\nRather\tO\n,\tO\nBNPP\tB-Chemical\npretreatment\tO\nreduced\tO\nthe\tO\nfraction\tO\nof\tO\nAPAP\tB-Chemical\nexcreted\tO\nas\tO\nPAP\tB-Chemical\nby\tO\n64\tO\nand\tO\n75\tO\n%\tO\nafter\tO\nAPAP\tB-Chemical\ndoses\tO\nof\tO\n750\tO\nand\tO\n900\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nBNPP\tB-Chemical\ndid\tO\nnot\tO\nalter\tO\nthe\tO\nexcretion\tO\nof\tO\nAPAP\tB-Chemical\nor\tO\nany\tO\nof\tO\nits\tO\nnon\tO\n-\tO\ndeacetylated\tO\nmetabolites\tO\nnor\tO\ndid\tO\nBNPP\tB-Chemical\nalter\tO\nexcretion\tO\nof\tO\nPAP\tB-Chemical\nor\tO\nits\tO\nmetabolites\tO\nafter\tO\nPAP\tB-Chemical\ndoses\tO\nof\tO\n150\tO\nand\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nTherefore\tO\n,\tO\nthe\tO\nBNPP\tB-Chemical\n-\tO\ninduced\tO\nreduction\tO\nin\tO\nAPAP\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\nappears\tO\nto\tO\nbe\tO\ndue\tO\nto\tO\ninhibition\tO\nof\tO\nAPAP\tB-Chemical\ndeacetylation\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nPAP\tB-Chemical\nformation\tO\n,\tO\nin\tO\nvivo\tO\n,\tO\naccounts\tO\n,\tO\nat\tO\nleast\tO\nin\tO\npart\tO\n,\tO\nfor\tO\nAPAP\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nMorphine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nin\tO\nnewborn\tO\ninfants\tO\n.\tO\n\nTwo\tO\nneonates\tO\nsuffered\tO\nfrom\tO\ngeneralized\tO\nseizures\tB-Disease\nduring\tO\nthe\tO\ncourse\tO\nof\tO\nintravenous\tO\nmorphine\tB-Chemical\nsulfate\tI-Chemical\nfor\tO\npost\tO\n-\tO\noperative\tO\nanalgesia\tO\n.\tO\n\nThey\tO\nreceived\tO\nmorphine\tB-Chemical\nin\tO\ndoses\tO\nof\tO\n32\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nhr\tO\nand\tO\n40\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nhr\tO\nlarger\tO\nthan\tO\na\tO\ngroup\tO\nof\tO\n10\tO\nneonates\tO\nwho\tO\nreceived\tO\n6\tO\n-\tO\n24\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nhr\tO\nand\tO\nhad\tO\nno\tO\nseizures\tB-Disease\n.\tO\n\nPlasma\tO\nconcentrations\tO\nof\tO\nmorphine\tB-Chemical\nin\tO\nthese\tO\nneonates\tO\nwas\tO\nexcessive\tO\n(\tO\n60\tO\nand\tO\n90\tO\nmg\tO\n/\tO\nml\tO\n)\tO\n.\tO\n\nOther\tO\nknown\tO\nreasons\tO\nfor\tO\nseizures\tB-Disease\nwere\tO\nruled\tO\nout\tO\nand\tO\nthe\tO\nconvulsions\tB-Disease\nstopped\tO\na\tO\nfew\tO\nhours\tO\nafter\tO\ncessation\tO\nof\tO\nmorphine\tB-Chemical\nand\tO\ndid\tO\nnot\tO\nreoccur\tO\nin\tO\nthe\tO\nsubsequent\tO\n8\tO\nmonths\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\npost\tO\n-\tO\noperative\tO\nintravenous\tO\nmorphine\tB-Chemical\nshould\tO\nnot\tO\nexceed\tO\n20\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nml\tO\nin\tO\nneonates\tO\n.\tO\n\nIndomethacin\tB-Chemical\ninduced\tO\nhypotension\tB-Disease\nin\tO\nsodium\tB-Chemical\nand\tO\nvolume\tO\ndepleted\tO\nrats\tO\n.\tO\n\nAfter\tO\na\tO\nsingle\tO\noral\tO\ndose\tO\nof\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\nindomethacin\tB-Chemical\n(\tO\nIDM\tB-Chemical\n)\tO\nto\tO\nsodium\tB-Chemical\nand\tO\nvolume\tO\ndepleted\tO\nrats\tO\nplasma\tO\nrenin\tO\nactivity\tO\n(\tO\nPRA\tO\n)\tO\nand\tO\nsystolic\tO\nblood\tO\npressure\tO\nfell\tO\nsignificantly\tO\nwithin\tO\nfour\tO\nhours\tO\n.\tO\n\nIn\tO\nsodium\tB-Chemical\nrepleted\tO\nanimals\tO\nindomethacin\tB-Chemical\ndid\tO\nnot\tO\nchange\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\nalthough\tO\nplasma\tO\nrenin\tO\nactivity\tO\nwas\tO\ndecreased\tO\n.\tO\n\nThus\tO\n,\tO\nindomethacin\tB-Chemical\nby\tO\ninhibition\tO\nof\tO\nprostaglandin\tB-Chemical\nsynthesis\tO\nmay\tO\ndiminish\tO\nthe\tO\nblood\tO\npressure\tO\nmaintaining\tO\neffect\tO\nof\tO\nthe\tO\nstimulated\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\nin\tO\nsodium\tB-Chemical\nand\tO\nvolume\tO\ndepletion\tO\n.\tO\n\nOn\tO\nthe\tO\nantiarrhythmic\tO\nactivity\tO\nof\tO\none\tO\nN\tO\n-\tO\nsubstituted\tO\npiperazine\tB-Chemical\nderivative\tO\nof\tO\ntrans\tB-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\namino\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ntetrahydroanaphthalene\tI-Chemical\n.\tO\n\nThe\tO\nantiarrhythmic\tO\nactivity\tO\nof\tO\nthe\tO\ncompound\tO\nN\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\ntrans\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ntetrahydro\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nnaphthyl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\noxo\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nphenyl\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nmethylpropyl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\npiperazine\tI-Chemical\nhydrochloride\tI-Chemical\n,\tO\nreferred\tO\nto\tO\nas\tO\nP11\tB-Chemical\n,\tO\nis\tO\nstudied\tO\non\tO\nanaesthesized\tO\ncats\tO\nand\tO\nWistar\tO\nalbino\tO\nrats\tO\n,\tO\nas\tO\nwell\tO\nas\tO\non\tO\nnon\tO\n-\tO\nanaesthesized\tO\nrabbits\tO\n.\tO\n\nFour\tO\ntypes\tO\nof\tO\nexperimental\tO\narrhythmia\tB-Disease\nare\tO\nused\tO\n-\tO\n-\tO\nwith\tO\nBaCl2\tB-Chemical\n,\tO\nwith\tO\nchloroform\tB-Chemical\n-\tO\nadrenaline\tB-Chemical\n,\tO\nwith\tO\nstrophantine\tB-Chemical\nG\tI-Chemical\nand\tO\nwith\tO\naconitine\tB-Chemical\n.\tO\n\nThe\tO\ncompound\tO\nP11\tB-Chemical\nis\tO\nintroduced\tO\nin\tO\ndoses\tO\nof\tO\n0\tO\n.\tO\n25\tO\nand\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nintravenously\tO\nand\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\norally\tO\n.\tO\n\nThe\tO\ncompound\tO\nmanifests\tO\nantiarrhythmic\tO\nactivity\tO\nin\tO\nall\tO\nmodels\tO\nof\tO\nexperimental\tO\narrhythmia\tB-Disease\nused\tO\n,\tO\ncausing\tO\ngreatest\tO\ninhibition\tO\non\tO\nthe\tO\narrhythmia\tB-Disease\ninduced\tO\nby\tO\nchloroform\tB-Chemical\n-\tO\nadrenaline\tB-Chemical\n(\tO\nin\tO\n90\tO\nper\tO\ncent\tO\n)\tO\nand\tO\nwith\tO\nBaCl2\tB-Chemical\n(\tO\nin\tO\n84\tO\nper\tO\ncent\tO\n)\tO\n.\tO\n\nThe\tO\nresults\tO\nobtained\tO\nare\tO\nassociated\tO\nwith\tO\nthe\tO\nbeta\tO\n-\tO\nadrenoblocking\tO\nand\tO\nwith\tO\nthe\tO\nmembrane\tO\n-\tO\nstabilizing\tO\naction\tO\nof\tO\nthe\tO\ncompound\tO\n.\tO\n\nRecurrent\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\nassociated\tO\nwith\tO\naminocaproic\tB-Chemical\nacid\tI-Chemical\ntherapy\tO\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\nartery\tI-Disease\nthrombosis\tI-Disease\n.\tO\n\nCase\tO\nreport\tO\n.\tO\n\nEpsilon\tB-Chemical\naminocaproic\tI-Chemical\nacid\tI-Chemical\n(\tO\nEACA\tB-Chemical\n)\tO\nhas\tO\nbeen\tO\nused\tO\nto\tO\nprevent\tO\nrebleeding\tO\nin\tO\npatients\tO\nwith\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\n(\tO\nSAH\tB-Disease\n)\tO\n.\tO\n\nAlthough\tO\nthis\tO\nagent\tO\ndoes\tO\ndecrease\tO\nthe\tO\nfrequency\tO\nof\tO\nrebleeding\tO\n,\tO\nseveral\tO\nreports\tO\nhave\tO\ndescribed\tO\nthrombotic\tB-Disease\ncomplications\tO\nof\tO\nEACA\tB-Chemical\ntherapy\tO\n.\tO\n\nThese\tO\ncomplications\tO\nhave\tO\nincluded\tO\nclinical\tO\ndeterioration\tO\nand\tO\nintracranial\tB-Disease\nvascular\tI-Disease\nthrombosis\tI-Disease\nin\tO\npatients\tO\nwith\tO\nSAH\tB-Disease\n,\tO\narteriolar\tO\nand\tO\ncapillary\tO\nfibrin\tO\nthrombi\tB-Disease\nin\tO\npatients\tO\nwith\tO\nfibrinolytic\tO\nsyndromes\tO\ntreated\tO\nwith\tO\nEACA\tB-Chemical\n,\tO\nor\tO\nother\tO\nthromboembolic\tB-Disease\nphenomena\tI-Disease\n.\tO\n\nSince\tO\nintravascular\tO\nfibrin\tO\nthrombi\tB-Disease\nare\tO\noften\tO\nobserved\tO\nin\tO\npatients\tO\nwith\tO\nfibrinolytic\tO\ndisorders\tO\n,\tO\nEACA\tB-Chemical\nshould\tO\nnot\tO\nbe\tO\nimplicated\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nfibrin\tO\nthrombi\tB-Disease\nin\tO\npatients\tO\nwith\tO\ndisseminated\tB-Disease\nintravascular\tI-Disease\ncoagulation\tI-Disease\nor\tO\nother\tO\n\"\tO\nconsumption\tB-Disease\ncoagulopathies\tI-Disease\n.\tO\n\"\tO\nThis\tO\nreport\tO\ndescribes\tO\nsubtotal\tO\ninfarction\tB-Disease\nof\tO\nthe\tO\nkidney\tO\ndue\tO\nto\tO\nthrombosis\tB-Disease\nof\tI-Disease\na\tI-Disease\nnormal\tI-Disease\nrenal\tI-Disease\nartery\tI-Disease\n.\tO\n\nThis\tO\nocclusion\tO\noccurred\tO\nafter\tO\nEACA\tB-Chemical\ntherapy\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nSAH\tB-Disease\nand\tO\nhistopathological\tO\ndocumentation\tO\nof\tO\nrecurrent\tO\nSAH\tB-Disease\n.\tO\n\nThe\tO\ncorresponding\tO\nclinical\tO\nevent\tO\nwas\tO\ncharacterized\tO\nby\tO\nmarked\tO\nhypertension\tB-Disease\nand\tO\nabrupt\tO\nneurological\tO\ndeterioration\tO\n.\tO\n\nEffect\tO\nof\tO\nvincristine\tB-Chemical\nsulfate\tI-Chemical\non\tO\nPseudomonas\tB-Disease\ninfections\tI-Disease\nin\tO\nmonkeys\tO\n.\tO\n\nIn\tO\nrhesus\tO\nmonkeys\tO\n,\tO\nintravenous\tO\nchallenge\tO\nwith\tO\n0\tO\n.\tO\n6\tO\nx\tO\n10\tO\n(\tO\n10\tO\n)\tO\nto\tO\n2\tO\n.\tO\n2\tO\nx\tO\n10\tO\n(\tO\n10\tO\n)\tO\nPseudomonas\tO\naeruginosa\tO\norganisms\tO\ncaused\tO\nacute\tO\nillness\tO\nof\tO\n4\tO\nto\tO\n5\tO\ndays\tO\n'\tO\nduration\tO\nwith\tO\nspontaneous\tO\nrecovery\tO\nin\tO\n13\tO\nof\tO\n15\tO\nmonkeys\tO\n;\tO\nblood\tO\ncultures\tO\nbecame\tO\nnegative\tO\n3\tO\nto\tO\n17\tO\ndays\tO\nafter\tO\nchallenge\tO\n.\tO\n\nLeukocytosis\tB-Disease\nwas\tO\nobserved\tO\nin\tO\nall\tO\nmonkeys\tO\n.\tO\n\nIntravenous\tO\nor\tO\nintratracheal\tO\ninoculation\tO\nof\tO\n2\tO\n.\tO\n0\tO\nto\tO\n2\tO\n.\tO\n5\tO\nmg\tO\nof\tO\nvincristine\tB-Chemical\nsulfate\tI-Chemical\nwas\tO\nfollowed\tO\nby\tO\nleukopenia\tB-Disease\nin\tO\n4\tO\nto\tO\n5\tO\ndays\tO\n.\tO\n\nIntravenous\tO\ninoculation\tO\nof\tO\n4\tO\n.\tO\n2\tO\nx\tO\n10\tO\n(\tO\n10\tO\n)\tO\nto\tO\n7\tO\n.\tO\n8\tO\nx\tO\n10\tO\n(\tO\n10\tO\n)\tO\npyocin\tO\ntype\tO\n6\tO\nPseudomonas\tO\norganisms\tO\nin\tO\nmonkeys\tO\ngiven\tO\nvincristine\tB-Chemical\nsulfate\tI-Chemical\n4\tO\ndays\tO\npreviously\tO\nresulted\tO\nin\tO\nfatal\tO\ninfection\tB-Disease\nin\tO\n11\tO\nof\tO\n14\tO\nmonkeys\tO\n,\tO\nwhereas\tO\nnone\tO\nof\tO\nfour\tO\nreceiving\tO\nPseudomonas\tO\nalone\tO\ndied\tO\n.\tO\n\nThese\tO\nstudies\tO\nsuggest\tO\nthat\tO\nan\tO\nantimetabolite\tO\n-\tO\ninduced\tO\nleukopenia\tB-Disease\npredisposes\tO\nto\tO\nsevere\tO\nPseudomonas\tO\nsepsis\tB-Disease\nand\tO\nthat\tO\nsuch\tO\nmonkeys\tO\nmay\tO\nserve\tO\nas\tO\na\tO\nbiological\tO\nmodel\tO\nfor\tO\nstudy\tO\nof\tO\ncomparative\tO\nefficacy\tO\nof\tO\nantimicrobial\tO\nagents\tO\n.\tO\n\nModification\tO\nby\tO\npropranolol\tB-Chemical\nof\tO\ncardiovascular\tO\neffects\tO\nof\tO\ninduced\tO\nhypoglycaemia\tB-Disease\n.\tO\n\nThe\tO\ncardiovascular\tO\neffects\tO\nof\tO\nhypoglycaemia\tB-Disease\n,\tO\nwith\tO\nand\tO\nwithout\tO\nbeta\tO\n-\tO\nblockade\tO\n,\tO\nwere\tO\ncompared\tO\nin\tO\nfourteen\tO\nhealthy\tO\nmen\tO\n.\tO\n\nEight\tO\nreceived\tO\ninsulin\tO\nalone\tO\n,\tO\nand\tO\neight\tO\n,\tO\nincluding\tO\ntwo\tO\nof\tO\nthe\tO\noriginal\tO\ninsulin\tO\n-\tO\nonly\tO\ngroup\tO\n,\tO\nwere\tO\ngiven\tO\npropranolol\tB-Chemical\nand\tO\ninsulin\tO\n.\tO\n\nIn\tO\nthe\tO\ninsulin\tO\n-\tO\ngroup\tO\nthe\tO\nperiod\tO\nof\tO\nhypoglycaemia\tB-Disease\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nheart\tO\n-\tO\nrate\tO\nand\tO\na\tO\nfall\tO\nin\tO\ndiastolic\tO\nblood\tO\n-\tO\npressure\tO\n.\tO\n\nIn\tO\nthe\tO\npropranolol\tB-Chemical\n-\tO\ninsulin\tO\ngroup\tO\nthere\tO\nwas\tO\na\tO\nsignificant\tO\nfall\tO\nin\tO\nheart\tO\n-\tO\nrate\tO\nin\tO\nmost\tO\nsubjects\tO\nand\tO\nan\tO\nincrease\tO\nin\tO\ndiastolic\tO\npressure\tO\n.\tO\n\nTypical\tO\nS\tO\n-\tO\nT\tO\n/\tO\nT\tO\nchanges\tO\noccurred\tO\nin\tO\nthe\tO\ninsulin\tO\n-\tO\ngroup\tO\nbut\tO\nin\tO\nnone\tO\nof\tO\nthe\tO\npropranolol\tB-Chemical\n-\tO\ninsulin\tO\ngroup\tO\n.\tO\n\nHypertension\tB-Disease\nin\tO\ndiabetics\tB-Disease\nprone\tO\nto\tO\nhypoglycaemia\tB-Disease\nattacks\tO\nshould\tO\nnot\tO\nbe\tO\ntreated\tO\nwith\tO\nbeta\tO\n-\tO\nblockers\tO\nbecause\tO\nthese\tO\ndrugs\tO\nmay\tO\ncause\tO\na\tO\nsharp\tO\nrise\tO\nin\tO\nblood\tO\n-\tO\npressure\tO\nin\tO\nsuch\tO\npatients\tO\n.\tO\n\nLong\tO\n-\tO\nterm\tO\npropranolol\tB-Chemical\ntherapy\tO\nin\tO\npregnancy\tO\n:\tO\nmaternal\tO\nand\tO\nfetal\tO\noutcome\tO\n.\tO\n\nPropranolol\tB-Chemical\n,\tO\na\tO\nbeta\tO\n-\tO\nadrenergic\tO\nblocking\tO\nagent\tO\n,\tO\nhas\tO\nfound\tO\nan\tO\nimportant\tO\nposition\tO\nin\tO\nthe\tO\npractice\tO\nof\tO\nmedicine\tO\n.\tO\n\nIts\tO\nuse\tO\nin\tO\npregnancy\tO\n,\tO\nhowever\tO\n,\tO\nis\tO\nan\tO\nopen\tO\nquestion\tO\nas\tO\na\tO\nnumber\tO\nof\tO\ndetrimental\tO\nside\tO\neffects\tO\nhave\tO\nbeen\tO\nreported\tO\nin\tO\nthe\tO\nfetus\tO\nand\tO\nneonate\tO\n.\tO\n\nTen\tO\npatients\tO\nand\tO\n12\tO\npregnancies\tO\nare\tO\nreported\tO\nwhere\tO\nchronic\tO\npropranolol\tB-Chemical\nhas\tO\nbeen\tO\nadministered\tO\n.\tO\n\nFive\tO\npatients\tO\nwith\tO\nserial\tO\npregnancies\tO\nwith\tO\nand\tO\nwithout\tO\npropranolol\tB-Chemical\ntherapy\tO\nare\tO\nalso\tO\nexamined\tO\n.\tO\n\nMaternal\tO\n,\tO\nfetal\tO\n,\tO\nand\tO\nneonatal\tO\ncomplications\tO\nare\tO\nexamined\tO\n.\tO\n\nAn\tO\nattempt\tO\nis\tO\nmade\tO\nto\tO\ndifferentiate\tO\ndrug\tO\n-\tO\nrelated\tO\ncomplications\tO\nfrom\tO\nmaternal\tO\ndisease\tO\n-\tO\n-\tO\nrelated\tO\ncomplications\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\npreviously\tO\nreported\tO\nhypoglycemia\tB-Disease\n,\tO\nhyperbilirubinemia\tB-Disease\n,\tO\npolycythemia\tB-Disease\n,\tO\nneonatal\tB-Disease\napnea\tI-Disease\n,\tO\nand\tO\nbradycardia\tB-Disease\nare\tO\nnot\tO\ninvariable\tO\nand\tO\ncannot\tO\nbe\tO\nstatistically\tO\ncorrelated\tO\nwith\tO\nchronic\tO\npropranolol\tB-Chemical\ntherapy\tO\n.\tO\n\nGrowth\tB-Disease\nretardation\tI-Disease\n,\tO\nhowever\tO\n,\tO\nappears\tO\nto\tO\nbe\tO\nsignificant\tO\nin\tO\nboth\tO\nof\tO\nour\tO\nseries\tO\n.\tO\n\nCentral\tO\nexcitatory\tO\nactions\tO\nof\tO\nflurazepam\tB-Chemical\n.\tO\n\nToxic\tO\nactions\tO\nof\tO\nflurazepam\tB-Chemical\n(\tO\nFZP\tB-Chemical\n)\tO\nwere\tO\nstudied\tO\nin\tO\ncats\tO\n,\tO\nmice\tO\nand\tO\nrats\tO\n.\tO\n\nHigh\tO\ndoses\tO\ncaused\tO\nan\tO\napparent\tO\ncentral\tO\nexcitation\tO\n,\tO\nmost\tO\nclearly\tO\nseen\tO\nas\tO\nclonic\tO\nconvulsions\tB-Disease\n,\tO\nsuperimposed\tO\non\tO\ngeneral\tO\ndepression\tB-Disease\n.\tO\n\nFollowing\tO\na\tO\nlethal\tO\ndose\tO\n,\tO\ndeath\tO\nwas\tO\nalways\tO\nassociated\tO\nwith\tO\nconvulsions\tB-Disease\n.\tO\n\nComparing\tO\nthe\tO\nrelative\tO\nsensitivity\tO\nto\tO\ncentral\tO\ndepression\tB-Disease\nand\tO\nexcitation\tO\nrevealed\tO\nthat\tO\nrats\tO\nwere\tO\nleast\tO\nlikely\tO\nto\tO\nhave\tO\nconvulsions\tB-Disease\nat\tO\ndoses\tO\nthat\tO\ndid\tO\nnot\tO\nfirst\tO\ncause\tO\nloss\tB-Disease\nof\tI-Disease\nconsciousness\tI-Disease\n,\tO\nwhile\tO\ncats\tO\nmost\tO\nclearly\tO\nshowed\tO\nmarked\tO\ncentral\tO\nexcitatory\tO\nactions\tO\n.\tO\n\nSigns\tO\nof\tO\nFZP\tB-Chemical\ntoxocity\tB-Disease\nin\tO\ncats\tO\nincluded\tO\nexcessive\tO\nsalivation\tB-Disease\n,\tO\nextreme\tO\napprehensive\tO\nbehavior\tO\n,\tO\nretching\tO\n,\tO\nmuscle\tB-Disease\ntremors\tI-Disease\nand\tO\nconvulsions\tB-Disease\n.\tO\n\nAn\tO\ninteraction\tO\nbetween\tO\nFZP\tB-Chemical\nand\tO\npentylenetetrazol\tB-Chemical\n(\tO\nPTZ\tB-Chemical\n)\tO\nwas\tO\nshown\tO\nby\tO\npretreating\tO\nmice\tO\nwith\tO\nFZP\tB-Chemical\nbefore\tO\nPTZ\tB-Chemical\nchallenge\tO\n.\tO\n\nAs\tO\na\tO\nfunction\tO\nof\tO\ndose\tO\n,\tO\nFZP\tB-Chemical\nfirst\tO\nprotected\tO\nagainst\tO\nconvulsions\tB-Disease\nand\tO\ndeath\tO\n.\tO\n\nAt\tO\nhigher\tO\ndoses\tO\n,\tO\nhowever\tO\n,\tO\nconvulsions\tB-Disease\nagain\tO\nemerged\tO\n.\tO\n\nThese\tO\ndoses\tO\nof\tO\nFZP\tB-Chemical\nwere\tO\nlower\tO\nthan\tO\nthose\tO\nthat\tO\nwould\tO\nalone\tO\ncause\tO\nconvulsions\tB-Disease\n.\tO\n\nThese\tO\nresults\tO\nmay\tO\nbe\tO\nrelevant\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\nFZP\tB-Chemical\nin\tO\nclinical\tO\nsituations\tO\nin\tO\nwhich\tO\nthere\tO\nis\tO\nincreased\tO\nneural\tO\nexcitability\tO\n,\tO\nsuch\tO\nas\tO\nepilepsy\tB-Disease\nor\tO\nsedative\tO\n-\tO\nhypnotic\tO\ndrug\tO\nwithdrawal\tO\n.\tO\n\nUse\tO\nof\tO\npropranolol\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nidiopathic\tB-Disease\northostatic\tI-Disease\nhypotension\tI-Disease\n.\tO\n\nFive\tO\npatients\tO\nwith\tO\nidiopathic\tB-Disease\northostatic\tI-Disease\nhypotension\tI-Disease\nwho\tO\nhad\tO\nphysiologic\tO\nand\tO\nbiochemical\tO\nevidence\tO\nof\tO\nsevere\tO\nautonomic\tO\ndysfunction\tO\nwere\tO\nincluded\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nThey\tO\nall\tO\nexhibited\tO\nmarkedly\tO\nreduced\tO\nplasma\tO\ncatecholamines\tB-Chemical\nand\tO\nplasma\tO\nrenin\tO\nactivity\tO\nin\tO\nboth\tO\nrecumbent\tO\nand\tO\nupright\tO\npositions\tO\nand\tO\nhad\tO\nmarked\tO\nhypersensitivity\tB-Disease\nto\tO\nthe\tO\npressor\tO\neffects\tO\nof\tO\ninfused\tO\nnorepinephrine\tB-Chemical\n.\tO\n\nTreatment\tO\nwith\tO\npropanolol\tB-Chemical\nadministered\tO\nintravenously\tO\n(\tO\n1\tO\n-\tO\n5\tO\nmg\tO\n)\tO\nproduced\tO\nincreases\tO\nin\tO\nsupine\tO\nand\tO\nupright\tO\nblood\tO\npressure\tO\nin\tO\n4\tO\nof\tO\nthe\tO\n5\tO\nindividuals\tO\nwith\tO\nrises\tO\nranging\tO\nfrom\tO\n11\tO\n/\tO\n6\tO\nto\tO\n22\tO\n/\tO\n11\tO\nmmHg\tO\n.\tO\n\nChronic\tO\noral\tO\nadministration\tO\nof\tO\npropranolol\tB-Chemical\n(\tO\n40\tO\n-\tO\n160\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nalso\tO\nelevated\tO\nthe\tO\nblood\tO\npressures\tO\nof\tO\nthese\tO\nindividuals\tO\nwith\tO\nincreases\tO\nin\tO\nthe\tO\norder\tO\nof\tO\n20\tO\n-\tO\n35\tO\n/\tO\n15\tO\n-\tO\n25\tO\nmmg\tO\nbeing\tO\nobserved\tO\n.\tO\n\nIn\tO\n1\tO\npatient\tO\n,\tO\nmarked\tO\nhypertension\tB-Disease\nwas\tO\ninduced\tO\nby\tO\npropranolol\tB-Chemical\nand\tO\nthe\tO\ndrug\tO\nhad\tO\nto\tO\nbe\tO\nwithdrawn\tO\n.\tO\n\nIt\tO\notherwise\tO\nwas\tO\nwell\tO\ntolerated\tO\nand\tO\nno\tO\nimportant\tO\nside\tO\neffects\tO\nwere\tO\nobserved\tO\n.\tO\n\nTreatment\tO\nhas\tO\nbeen\tO\ncontinued\tO\nin\tO\n3\tO\nindividuals\tO\nfor\tO\n6\tO\n-\tO\n13\tO\nmonths\tO\nwith\tO\npersistence\tO\nof\tO\nthe\tO\npressor\tO\neffect\tO\n,\tO\nalthough\tO\nthere\tO\nappears\tO\nto\tO\nhave\tO\nbeen\tO\nsome\tO\ndecrease\tO\nin\tO\nthe\tO\ndegree\tO\nof\tO\nresponse\tO\nwith\tO\ntime\tO\n.\tO\n\nHemodynamic\tO\nmeasurements\tO\nin\tO\n1\tO\nof\tO\nthe\tO\npatients\tO\ndemonstrated\tO\nan\tO\nincrease\tO\nin\tO\ntotal\tO\nperipheral\tO\nresistance\tO\nand\tO\nessentially\tO\nno\tO\nchange\tO\nin\tO\ncardiac\tO\noutput\tO\nfollowing\tO\npropranolol\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\nstudies\tO\nsuggest\tO\nthat\tO\npropranolol\tB-Chemical\nis\tO\na\tO\nuseful\tO\ndrug\tO\nin\tO\nselected\tO\npatients\tO\nwith\tO\nsevere\tO\nidiopathic\tB-Disease\northostatic\tI-Disease\nhypotension\tI-Disease\n.\tO\n\nTotal\tO\nintravenous\tO\nanesthesia\tO\nwith\tO\netomidate\tB-Chemical\n.\tO\n\nIII\tO\n.\tO\n\nSome\tO\nobservations\tO\nin\tO\nadults\tO\n.\tO\n\nAn\tO\ninvestigation\tO\nwas\tO\nundertaken\tO\nto\tO\ndetermine\tO\nthe\tO\ndosage\tO\nof\tO\netomidate\tB-Chemical\nrequired\tO\nto\tO\nmaintain\tO\nsleep\tO\nin\tO\nadults\tO\nundergoing\tO\nsurgery\tO\nunder\tO\nregional\tO\nlocal\tO\nanesthesia\tO\n.\tO\n\nPremedication\tO\nof\tO\ndiazepam\tB-Chemical\n10\tO\nmg\tO\nand\tO\natropine\tB-Chemical\n0\tO\n.\tO\n5\tO\nmg\tO\nwas\tO\ngiven\tO\n,\tO\nand\tO\nsleep\tO\nwas\tO\ninduced\tO\nand\tO\nmaintained\tO\nby\tO\nintermittent\tO\nintravenous\tO\ninjections\tO\nof\tO\netomidate\tB-Chemical\n0\tO\n.\tO\n1\tO\n/\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ngiven\tO\nwhenever\tO\nthe\tO\npatient\tO\nwould\tO\nopen\tO\nhis\tO\neyes\tO\non\tO\nrequest\tO\n.\tO\n\nA\tO\nmean\tO\noverall\tO\ndose\tO\nof\tO\netomidate\tB-Chemical\n17\tO\n.\tO\n4\tO\nmicrogram\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n.\tO\nwas\tO\nrequired\tO\nto\tO\nmaintain\tO\nsleep\tO\n,\tO\nbut\tO\ngreat\tO\nindividual\tO\nvariation\tO\noccurred\tO\n,\tO\nwith\tO\nolder\tO\npatients\tO\nrequiring\tO\nless\tO\ndrug\tO\n.\tO\n\nThe\tO\ninvestigation\tO\nwas\tO\ndiscontinued\tO\nafter\tO\n18\tO\npatients\tO\nbecause\tO\nof\tO\nthe\tO\nfrequency\tO\nand\tO\nintensity\tO\nof\tO\nside\tO\n-\tO\neffects\tO\n,\tO\nparticularly\tO\npain\tB-Disease\nand\tO\nmyoclonia\tB-Disease\n,\tO\nwhich\tO\ncaused\tO\nthe\tO\ntechnique\tO\nto\tO\nbe\tO\nabandoned\tO\nin\tO\ntwo\tO\ncases\tO\n.\tO\n\nIt\tO\nis\tO\nconsidered\tO\nunlikely\tO\nthat\tO\netomidate\tB-Chemical\nwill\tO\nprove\tO\nto\tO\nbe\tO\nthe\tO\nhypnotic\tO\nof\tO\nchoice\tO\nfor\tO\na\tO\ntotally\tO\nintravenous\tO\nanesthetic\tO\ntechnique\tO\nin\tO\nadults\tO\nbecause\tO\nof\tO\nthe\tO\nhigh\tO\nincidence\tO\nof\tO\nmyoclonia\tB-Disease\nafter\tO\nprolonged\tO\nadministration\tO\n.\tO\n\nIn\tO\nseveral\tO\npatients\tO\nuncontrollable\tO\nmuscle\tO\nmovements\tO\npersisted\tO\nfor\tO\nmany\tO\nminutes\tO\nafter\tO\ncomplete\tO\nrecovery\tO\nof\tO\nconsciousness\tO\n.\tO\n\nEvidence\tO\nfor\tO\ncardiac\tO\nbeta\tO\n2\tO\n-\tO\nadrenoceptors\tO\nin\tO\nman\tO\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\neffects\tO\nof\tO\nsingle\tO\ndoses\tO\nof\tO\n50\tO\nmg\tO\natenolol\tB-Chemical\n(\tO\ncardioselective\tO\n)\tO\n,\tO\n40\tO\nmg\tO\npropranolol\tB-Chemical\n(\tO\nnonselective\tO\n)\tO\n,\tO\nand\tO\nplacebo\tO\non\tO\nboth\tO\nexercise\tO\n-\tO\nand\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nin\tO\ntwo\tO\nexperiments\tO\ninvolving\tO\nnine\tO\nnormal\tO\nsubjects\tO\n.\tO\n\nMaximal\tO\nexercise\tO\nheart\tO\nrate\tO\nwas\tO\nreduced\tO\nfrom\tO\n187\tO\n+\tO\n/\tO\n-\tO\n4\tO\n(\tO\nSEM\tO\n)\tO\nafter\tO\nplacebo\tO\nto\tO\n146\tO\n+\tO\n/\tO\n-\tO\n7\tO\nbpm\tO\nafter\tO\natenolol\tB-Chemical\nand\tO\n138\tO\n+\tO\n/\tO\n-\tO\n6\tO\nbpm\tO\nafter\tO\npropranolol\tB-Chemical\n,\tO\nbut\tO\nthere\tO\nwere\tO\nno\tO\ndifferences\tO\nbetween\tO\nthe\tO\ndrugs\tO\n.\tO\n\nThe\tO\neffects\tO\non\tO\nisoproterenol\tB-Chemical\ntachycardia\tB-Disease\nwere\tO\ndetermined\tO\nbefore\tO\nand\tO\nafter\tO\natropine\tB-Chemical\n(\tO\n0\tO\n.\tO\n04\tO\nmg\tO\n/\tO\nkg\tO\nIV\tO\n)\tO\n.\tO\n\nIsoproterenol\tB-Chemical\nsensitivity\tO\nwas\tO\ndetermined\tO\nas\tO\nthe\tO\nintravenous\tO\ndose\tO\nthat\tO\nincreased\tO\nheart\tO\nrate\tO\nby\tO\n25\tO\nbpm\tO\n(\tO\nCD25\tO\n)\tO\nand\tO\nthis\tO\nwas\tO\nincreased\tO\nfrom\tO\n1\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n3\tO\nmicrograms\tO\nafter\tO\nplacebo\tO\nto\tO\n38\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n8\tO\n.\tO\n3\tO\nmicrograms\tO\nafter\tO\npropranolol\tB-Chemical\nand\tO\n8\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n7\tO\nmicrograms\tO\nafter\tO\natenolol\tB-Chemical\n.\tO\n\nThe\tO\ndifference\tO\nin\tO\nthe\tO\neffects\tO\nof\tO\nthe\tO\ntwo\tO\nwas\tO\nsignificant\tO\n.\tO\n\nAfter\tO\natropine\tB-Chemical\nthe\tO\nCD25\tO\nwas\tO\nunchanged\tO\nafter\tO\nplacebo\tO\n(\tO\n2\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n3\tO\nmicrograms\tO\n)\tO\nand\tO\natenolol\tB-Chemical\n(\tO\n7\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n3\tO\nmicrograms\tO\n)\tO\n;\tO\nit\tO\nwas\tO\nreduced\tO\nafter\tO\npropranolol\tB-Chemical\n(\tO\n24\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n0\tO\nmicrograms\tO\n)\tO\n,\tO\nbut\tO\nremained\tO\ndifferent\tO\nfrom\tO\natenolol\tB-Chemical\n.\tO\n\nThis\tO\nchange\tO\nwith\tO\npropranolol\tB-Chemical\nsensitivity\tO\nwas\tO\ncalculated\tO\nas\tO\nthe\tO\napparent\tO\nKa\tO\n,\tO\nthis\tO\nwas\tO\nunchanged\tO\nby\tO\natropine\tB-Chemical\n(\tO\n11\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\nand\tO\n10\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n5\tO\nml\tO\n/\tO\nng\tO\n)\tO\n.\tO\n\nThese\tO\ndata\tO\nare\tO\nconsistent\tO\nwith\tO\nthe\tO\nhypothesis\tO\nthat\tO\nexercise\tO\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nresults\tO\nlargely\tO\nfrom\tO\nbeta\tO\n1\tO\n-\tO\nreceptor\tO\nactivation\tO\nthat\tO\nis\tO\nblocked\tO\nby\tO\nboth\tO\ncardioselective\tO\nand\tO\nnonselective\tO\ndrugs\tO\n,\tO\nwhereas\tO\nisoproterenol\tB-Chemical\nactivates\tO\nboth\tO\nbeta\tO\n1\tO\n-\tO\nand\tO\nbeta\tO\n2\tO\n-\tO\nreceptors\tO\nso\tO\nthat\tO\nafter\tO\ncardioselective\tO\nblockade\tO\nthere\tO\nremains\tO\na\tO\nbeta\tO\n2\tO\n-\tO\ncomponent\tO\nthat\tO\ncan\tO\nbe\tO\nblocked\tO\nwith\tO\na\tO\nnonselective\tO\ndrug\tO\n.\tO\n\nWhile\tO\nthere\tO\nappear\tO\nto\tO\nbe\tO\nbeta\tO\n2\tO\n-\tO\nreceptors\tO\nin\tO\nthe\tO\nhuman\tO\nheart\tO\n,\tO\ntheir\tO\nphysiologic\tO\nor\tO\npathologic\tO\nroles\tO\nremain\tO\nto\tO\nbe\tO\ndefined\tO\n.\tO\n\nHormones\tO\nand\tO\nrisk\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nThis\tO\npaper\tO\nreports\tO\nthe\tO\nresults\tO\nof\tO\na\tO\nstudy\tO\nof\tO\n50\tO\nmenopausal\tO\nwomen\tO\nreceiving\tO\nhormonal\tO\nreplacement\tO\ntherapy\tO\n.\tO\n\nThe\tO\nmajority\tO\n(\tO\n29\tO\n)\tO\nhad\tO\nsurgical\tO\nmenopause\tO\n;\tO\ntheir\tO\nmean\tO\nage\tO\nwas\tO\n45\tO\n.\tO\n7\tO\nyears\tO\n.\tO\n\nIt\tO\nwas\tO\nhypothesized\tO\nthat\tO\nprogestins\tB-Chemical\ncould\tO\nequilibrate\tO\nthe\tO\neffects\tO\nof\tO\nthe\tO\nestrogenic\tO\nstimulation\tO\non\tO\nthe\tO\nmammary\tO\nand\tO\nendometrial\tO\ntarget\tO\ntissues\tO\nof\tO\nwomen\tO\non\tO\nhormonal\tO\nreplacement\tO\ntherapy\tO\n.\tO\n\nThe\tO\ntreatment\tO\nschedule\tO\nconsisted\tO\nof\tO\nconjugated\tB-Chemical\nestrogens\tI-Chemical\n(\tO\nPremarin\tB-Chemical\n)\tO\n1\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\n21\tO\ndays\tO\nand\tO\nMedroxyprogesterone\tB-Chemical\nacetate\tI-Chemical\n10\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\n10\tO\ndays\tO\nin\tO\neach\tO\nmonth\tO\n.\tO\n\nThe\tO\nmean\tO\ntreatment\tO\nperiod\tO\nwas\tO\n18\tO\nmonths\tO\n.\tO\n\nDuring\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n,\tO\nattention\tO\nwas\tO\npaid\tO\nto\tO\nbreast\tO\nmodifications\tO\nas\tO\nevidenced\tO\nby\tO\nsymptomatology\tO\n,\tO\nphysical\tO\nexamination\tO\n,\tO\nand\tO\nplate\tO\nthermography\tO\n.\tO\n\nMastodynia\tB-Disease\nwas\tO\nreported\tO\nby\tO\n21\tO\npatients\tO\n,\tO\nand\tO\nphysical\tO\nexamination\tO\nrevealed\tO\na\tO\nlight\tO\nincrease\tO\nin\tO\nbreast\tO\nfirmness\tO\nin\tO\n12\tO\nwomen\tO\nand\tO\na\tO\nmoderate\tO\nincrease\tO\nin\tO\nbreast\tO\nnodularity\tO\nin\tO\n2\tO\nwomen\tO\n.\tO\n\nThemography\tO\nconfirmed\tO\nthe\tO\nexistence\tO\nof\tO\nan\tO\nexcessive\tO\nbreast\tO\nstimulation\tO\nin\tO\n1\tO\nwomen\tO\nwho\tO\ncomplained\tO\nof\tO\nmoderate\tO\nmastodynia\tB-Disease\nand\tO\nin\tO\n5\tO\nof\tO\nthe\tO\n7\tO\nwomen\tO\nwho\tO\ncomplained\tO\nof\tO\nsevere\tO\nmastodynia\tB-Disease\n.\tO\n\nNormalization\tO\nwas\tO\nobtained\tO\nby\tO\nhalving\tO\nthe\tO\nestrogen\tB-Chemical\ndose\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nhormonal\tO\nreplacement\tO\ntherapy\tO\ncan\tO\nbe\tO\nsafely\tO\nprescribed\tO\nif\tO\nthe\tO\nfollowing\tO\ncriteria\tO\nare\tO\nsatisfied\tO\n:\tO\n1\tO\n)\tO\npreliminary\tO\nevaluation\tO\nof\tO\npatients\tO\nfrom\tO\na\tO\nclinical\tO\n,\tO\nmetabolic\tO\n,\tO\ncytologic\tO\n,\tO\nand\tO\nmammographic\tO\nperspective\tO\n;\tO\n2\tO\n)\tO\ncyclic\tO\ntreatment\tO\nschedule\tO\n,\tO\nwith\tO\na\tO\nprogestative\tO\nphase\tO\nof\tO\n10\tO\ndays\tO\n;\tO\nand\tO\n3\tO\n)\tO\nperiodic\tO\ncomplete\tO\nfollow\tO\n-\tO\nup\tO\n,\tO\nwith\tO\naccurate\tO\nthermographic\tO\nevaluation\tO\nof\tO\nthe\tO\nbreast\tO\ntarget\tO\ntissues\tO\n.\tO\n\nEarly\tO\ninfections\tB-Disease\nin\tO\nkidney\tO\n,\tO\nheart\tO\n,\tO\nand\tO\nliver\tO\ntransplant\tO\nrecipients\tO\non\tO\ncyclosporine\tB-Chemical\n.\tO\n\nEighty\tO\n-\tO\none\tO\nrenal\tO\n,\tO\nseventeen\tO\nheart\tO\n,\tO\nand\tO\ntwenty\tO\n-\tO\nfour\tO\nliver\tO\ntransplant\tO\npatients\tO\nwere\tO\nfollowed\tO\nfor\tO\ninfection\tB-Disease\n.\tO\n\nSeventeen\tO\nrenal\tO\npatients\tO\nreceived\tO\nazathioprine\tB-Chemical\n(\tO\nAza\tB-Chemical\n)\tO\nand\tO\nprednisone\tB-Chemical\nas\tO\npart\tO\nof\tO\na\tO\nrandomized\tO\ntrial\tO\nof\tO\nimmunosuppression\tO\nwith\tO\n21\tO\ncyclosporine\tB-Chemical\n-\tO\nand\tO\n-\tO\nprednisone\tB-Chemical\n-\tO\ntreated\tO\nrenal\tO\ntransplant\tO\npatients\tO\n.\tO\n\nAll\tO\nothers\tO\nreceived\tO\ncyclosporine\tB-Chemical\nand\tO\nprednisone\tB-Chemical\n.\tO\n\nThe\tO\nrandomized\tO\nAza\tB-Chemical\npatients\tO\nhad\tO\nmore\tO\noverall\tO\ninfections\tB-Disease\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nmore\tO\nnonviral\tO\ninfections\tB-Disease\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n02\tO\n)\tO\nthan\tO\nthe\tO\nrandomized\tO\ncyclosporine\tB-Chemical\npatients\tO\n.\tO\n\nHeart\tO\nand\tO\nliver\tO\npatients\tO\nhad\tO\nmore\tO\ninfections\tB-Disease\nthan\tO\ncyclosporine\tB-Chemical\nrenal\tO\npatients\tO\nbut\tO\nfewer\tO\ninfections\tB-Disease\nthan\tO\nthe\tO\nAza\tB-Chemical\nrenal\tO\npatients\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\ninfectious\tO\ndeaths\tO\nin\tO\nrenal\tO\ntransplant\tO\npatients\tO\non\tO\ncyclosporine\tB-Chemical\nor\tO\nAza\tB-Chemical\n,\tO\nbut\tO\ninfection\tB-Disease\nplayed\tO\na\tO\nmajor\tO\nrole\tO\nin\tO\n3\tO\nout\tO\nof\tO\n6\tO\ncardiac\tO\ntransplant\tO\ndeaths\tO\nand\tO\nin\tO\n8\tO\nout\tO\nof\tO\n9\tO\nliver\tO\ntransplant\tO\ndeaths\tO\n.\tO\n\nRenal\tO\npatients\tO\non\tO\ncyclosporine\tB-Chemical\nhad\tO\nthe\tO\nfewest\tO\nbacteremias\tB-Disease\n.\tO\n\nAnalysis\tO\nof\tO\nsite\tO\nof\tO\ninfection\tB-Disease\nshowed\tO\na\tO\npreponderance\tO\nof\tO\nabdominal\tB-Disease\ninfections\tI-Disease\nin\tO\nliver\tO\npatients\tO\n,\tO\nintrathoracic\tO\ninfections\tB-Disease\nin\tO\nheart\tO\npatients\tO\n,\tO\nand\tO\nurinary\tB-Disease\ntract\tI-Disease\ninfections\tI-Disease\nin\tO\nrenal\tO\npatients\tO\n.\tO\n\nPulmonary\tO\ninfections\tB-Disease\nwere\tO\nless\tO\ncommon\tO\nin\tO\ncyclosporine\tB-Chemical\n-\tO\ntreated\tO\nrenal\tO\npatients\tO\nthan\tO\nin\tO\nAza\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nAza\tB-Chemical\npatients\tO\nhad\tO\nsignificantly\tO\nmore\tO\nstaphylococcal\tB-Disease\ninfections\tI-Disease\nthan\tO\nall\tO\nother\tO\ntransplant\tO\ngroups\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n005\tO\n)\tO\n,\tO\nand\tO\nsystemic\tO\nfungal\tB-Disease\ninfections\tI-Disease\noccurred\tO\nonly\tO\nin\tO\nthe\tO\nliver\tO\ntransplant\tO\ngroup\tO\n.\tO\n\nCytomegalovirus\tO\n(\tO\nCMV\tO\n)\tO\nshedding\tO\nor\tO\nserological\tO\nrises\tO\nin\tO\nantibody\tO\ntiter\tO\n,\tO\nor\tO\nboth\tO\noccurred\tO\nin\tO\n78\tO\n%\tO\nof\tO\ncyclosporine\tB-Chemical\npatients\tO\nand\tO\n76\tO\n%\tO\nof\tO\nAza\tB-Chemical\npatients\tO\n.\tO\n\nOf\tO\nthe\tO\ncyclosporine\tB-Chemical\npatients\tO\n,\tO\n15\tO\n%\tO\nhad\tO\nsymptoms\tO\nrelated\tO\nto\tO\nCMV\tB-Disease\ninfection\tI-Disease\n.\tO\n\nSerological\tO\nevidence\tO\nfor\tO\nEpstein\tB-Disease\nBarr\tI-Disease\nVirus\tI-Disease\ninfection\tI-Disease\nwas\tO\nfound\tO\nin\tO\n20\tO\n%\tO\nof\tO\n65\tO\ncyclosporine\tB-Chemical\npatients\tO\nstudied\tO\n.\tO\n\nThree\tO\nhad\tO\nassociated\tO\nsymptoms\tO\n,\tO\nand\tO\none\tO\ndeveloped\tO\na\tO\nlymphoma\tB-Disease\n.\tO\n\nStructure\tO\n-\tO\nactivity\tO\nand\tO\ndose\tO\n-\tO\neffect\tO\nrelationships\tO\nof\tO\nthe\tO\nantagonism\tO\nof\tO\npicrotoxin\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nby\tO\ncholecystokinin\tB-Chemical\n,\tO\nfragments\tO\nand\tO\nanalogues\tO\nof\tO\ncholecystokinin\tB-Chemical\nin\tO\nmice\tO\n.\tO\n\nIntraperitoneal\tO\nadministration\tO\nof\tO\ncholecystokinin\tB-Chemical\noctapeptide\tI-Chemical\nsulphate\tO\nester\tO\n(\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n-\tO\nSE\tO\n)\tO\nand\tO\nnonsulphated\tO\ncholecystokinin\tB-Chemical\noctapeptide\tI-Chemical\n(\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n-\tO\nNS\tO\n)\tO\nenhanced\tO\nthe\tO\nlatency\tO\nof\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\npicrotoxin\tB-Chemical\nin\tO\nmice\tO\n.\tO\n\nExperiments\tO\nwith\tO\nN\tO\n-\tO\nand\tO\nC\tO\n-\tO\nterminal\tO\nfragments\tO\nrevealed\tO\nthat\tO\nthe\tO\nC\tO\n-\tO\nterminal\tO\ntetrapeptide\tO\n(\tO\nCCK\tO\n-\tO\n5\tO\n-\tO\n8\tO\n)\tO\nwas\tO\nthe\tO\nactive\tO\ncentre\tO\nof\tO\nthe\tO\nCCK\tO\noctapeptide\tO\nmolecule\tO\n.\tO\n\nThe\tO\nanalogues\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n-\tO\nSE\tO\nand\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n-\tO\nNS\tO\n(\tO\ndose\tO\nrange\tO\n0\tO\n.\tO\n2\tO\n-\tO\n6\tO\n.\tO\n4\tO\nmumol\tO\n/\tO\nkg\tO\n)\tO\nand\tO\ncaerulein\tB-Chemical\ndose\tO\nrange\tO\n0\tO\n.\tO\n1\tO\n-\tO\n0\tO\n.\tO\n8\tO\nmumol\tO\n/\tO\nkg\tO\n)\tO\nshowed\tO\nbell\tO\n-\tO\nshaped\tO\ndose\tO\n-\tO\neffect\tO\ncurves\tO\n,\tO\nwith\tO\nthe\tO\ngreatest\tO\nmaximum\tO\ninhibition\tO\nfor\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n-\tO\nNS\tO\n.\tO\n\nThe\tO\npeptide\tO\nCCK\tO\n-\tO\n5\tO\n-\tO\n8\tO\nhad\tO\nweak\tO\nanticonvulsant\tO\nactivity\tO\nin\tO\ncomparison\tO\nto\tO\nthe\tO\noctapeptides\tO\n,\tO\n3\tO\n.\tO\n2\tO\nmumol\tO\n/\tO\nkg\tO\nand\tO\nlarger\tO\ndoses\tO\nof\tO\nthe\tO\nreference\tO\ndrug\tO\n,\tO\ndiazepam\tB-Chemical\n,\tO\ntotally\tO\nprevented\tO\npicrotoxin\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nmortality\tO\n.\tO\n\nThe\tO\nmaximum\tO\neffect\tO\nof\tO\nthe\tO\npeptides\tO\ntested\tO\nwas\tO\nless\tO\nthan\tO\nthat\tO\nof\tO\ndiazepam\tB-Chemical\n.\tO\n\nExperiments\tO\nwith\tO\nanalogues\tO\nand\tO\nderivatives\tO\nof\tO\nCCK\tO\n-\tO\n5\tO\n-\tO\n8\tO\ndemonstrated\tO\nthat\tO\nthe\tO\neffectiveness\tO\nof\tO\nthe\tO\nbeta\tO\n-\tO\nalanyl\tO\nderivatives\tO\nof\tO\nCCK\tO\n-\tO\n5\tO\n-\tO\n8\tO\nwere\tO\nenhanced\tO\nand\tO\nthat\tO\nthey\tO\nwere\tO\nequipotent\tO\nwith\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n-\tO\nSE\tO\n.\tO\n\nOf\tO\nthe\tO\nCCK\tO\n-\tO\n2\tO\n-\tO\n8\tO\nanalogues\tO\n,\tO\nSer\tO\n(\tO\nSO3H\tO\n)\tO\n7\tO\n-\tO\nAc\tO\n-\tO\nCCK\tO\n-\tO\n2\tO\n-\tO\n8\tO\n-\tO\nSE\tO\nand\tO\nThr\tO\n(\tO\nSO3H\tO\n)\tO\n7\tO\n-\tO\nAc\tO\n-\tO\nCCK\tO\n-\tO\n2\tO\n-\tO\n8\tO\n-\tO\nSE\tO\nand\tO\nHyp\tO\n(\tO\nSO3H\tO\n)\tO\n-\tO\nAc\tO\n-\tO\nCCK\tO\n-\tO\n2\tO\n-\tO\n8\tO\n-\tO\nSE\tO\nwere\tO\nslightly\tO\nmore\tO\nactive\tO\nthan\tO\nCCK\tB-Chemical\n-\tI-Chemical\n8\tI-Chemical\n-\tO\nSE\tO\n.\tO\n\nVasopressin\tB-Chemical\nas\tO\na\tO\npossible\tO\ncontributor\tO\nto\tO\nhypertension\tB-Disease\n.\tO\n\nThe\tO\nrole\tO\nof\tO\nvasopressin\tB-Chemical\nas\tO\na\tO\npressor\tO\nagent\tO\nto\tO\nthe\tO\nhypertensive\tB-Disease\nprocess\tO\nwas\tO\nexamined\tO\n.\tO\n\nVasopressin\tB-Chemical\nplays\tO\na\tO\nmajor\tO\nrole\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nDOCA\tB-Chemical\n-\tO\nsalt\tO\nhypertension\tB-Disease\n,\tO\nsince\tO\nthe\tO\nelevation\tO\nof\tO\nblood\tO\npressure\tO\nwas\tO\nnot\tO\nsubstantial\tO\nin\tO\nthe\tO\nrats\tO\nwith\tO\nlithium\tB-Chemical\n-\tO\ntreated\tO\ndiabetes\tB-Disease\ninsipidus\tI-Disease\nafter\tO\nDOCA\tB-Chemical\n-\tO\nsalt\tO\ntreatment\tO\n.\tO\n\nAdministration\tO\nof\tO\nDDAVP\tB-Chemical\nwhich\tO\nhas\tO\nantidiuretic\tO\naction\tO\nbut\tO\nminimal\tO\nvasopressor\tO\neffect\tO\nfailed\tO\nto\tO\nincrease\tO\nblood\tO\npressure\tO\nto\tO\nthe\tO\nlevels\tO\nobserved\tO\nafter\tO\nadministration\tO\nof\tO\nAVP\tO\n.\tO\n\nFurthermore\tO\n,\tO\nthe\tO\npressor\tO\naction\tO\nof\tO\nvasopressin\tB-Chemical\nappears\tO\nto\tO\nbe\tO\nimportant\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nthis\tO\nmodel\tO\nof\tO\nhypertension\tB-Disease\n,\tO\nsince\tO\nthe\tO\nenhanced\tO\npressor\tO\nresponsiveness\tO\nto\tO\nthe\tO\nhormone\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\ninitial\tO\nstage\tO\nof\tO\nhypertension\tB-Disease\n.\tO\n\nIncreased\tO\nsecretion\tO\nof\tO\nvasopressin\tB-Chemical\nfrom\tO\nneurohypophysis\tO\nalso\tO\npromotes\tO\nthe\tO\nfunction\tO\nof\tO\nthe\tO\nhormone\tO\nas\tO\na\tO\npathogenetic\tO\nfactor\tO\nin\tO\nhypertension\tB-Disease\n.\tO\n\nAn\tO\nunproportional\tO\nrelease\tO\nof\tO\nvasopressin\tB-Chemical\ncompared\tO\nto\tO\nplasma\tO\nosmolality\tO\nmay\tO\nbe\tO\ninduced\tO\nby\tO\nthe\tO\nabsence\tO\nof\tO\nan\tO\nadjusting\tO\ncontrol\tO\nof\tO\nangiotensin\tB-Chemical\nII\tO\nforming\tO\nand\tO\nreceptor\tO\nbinding\tO\ncapacity\tO\nfor\tO\nsodium\tB-Chemical\nbalance\tO\nin\tO\nthe\tO\nbrain\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nrole\tO\nof\tO\nvasopressin\tB-Chemical\nremains\tO\nto\tO\nbe\tO\ndetermined\tO\nin\tO\nhuman\tO\nessential\tO\nhypertension\tB-Disease\n.\tO\n\nToxic\tB-Disease\nhepatitis\tI-Disease\ninduced\tO\nby\tO\ndisulfiram\tB-Chemical\nin\tO\na\tO\nnon\tO\n-\tO\nalcoholic\tO\n.\tO\n\nA\tO\nreversible\tO\ntoxic\tB-Disease\nliver\tI-Disease\ndamage\tI-Disease\nwas\tO\nobserved\tO\nin\tO\na\tO\nnon\tO\n-\tO\nalcoholic\tO\nwoman\tO\ntreated\tO\nwith\tO\ndisulfiram\tB-Chemical\n.\tO\n\nThe\tO\ncausative\tO\nrelationship\tO\nwas\tO\nproven\tO\nby\tO\nchallenge\tO\n.\tO\n\nAtrial\tB-Disease\nthrombosis\tI-Disease\ninvolving\tO\nthe\tO\nheart\tO\nof\tO\nF\tO\n-\tO\n344\tO\nrats\tO\ningesting\tO\nquinacrine\tB-Chemical\nhydrochloride\tI-Chemical\n.\tO\n\nQuinacrine\tB-Chemical\nhydrochloride\tI-Chemical\nis\tO\ntoxic\tO\nfor\tO\nthe\tO\nheart\tO\nof\tO\nF\tO\n-\tO\n344\tO\nrats\tO\n.\tO\n\nRats\tO\ntreated\tO\nwith\tO\n500\tO\nppm\tO\nquinacrine\tB-Chemical\nhydrochloride\tI-Chemical\nin\tO\nthe\tO\ndiet\tO\nall\tO\ndeveloped\tO\na\tO\nhigh\tO\nincidence\tO\nof\tO\nleft\tO\natrial\tB-Disease\nthrombosis\tI-Disease\n.\tO\n\nThe\tO\nlesion\tO\nwas\tO\nassociated\tO\nwith\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\nand\tO\ndilatation\tO\nand\tO\nfocal\tO\nmyocardial\tB-Disease\ndegeneration\tI-Disease\n.\tO\n\nRats\tO\ndied\tO\nfrom\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\nwith\tO\nsevere\tO\nacute\tO\nand\tO\nchronic\tO\ncongestion\tO\nof\tO\nthe\tO\nlungs\tO\n,\tO\nliver\tO\n,\tO\nand\tO\nother\tO\norgans\tO\n.\tO\n\nSeventy\tO\npercent\tO\nof\tO\nrats\tO\ngiven\tO\n250\tO\nppm\tO\nquinacrine\tB-Chemical\nhydrochloride\tI-Chemical\nand\tO\n1\tO\n,\tO\n000\tO\nppm\tO\nsodium\tB-Chemical\nnitrite\tI-Chemical\nsimultaneously\tO\nin\tO\nthe\tO\ndiet\tO\nhad\tO\nthrombosis\tB-Disease\nof\tO\nthe\tO\natria\tO\nof\tO\nthe\tO\nheart\tO\n,\tO\nwhile\tO\nuntreated\tO\ncontrol\tO\nrats\tO\nin\tO\nthis\tO\nlaboratory\tO\ndid\tO\nnot\tO\nhave\tO\natrial\tB-Disease\nthrombosis\tI-Disease\n.\tO\n\nSodium\tB-Chemical\nnitrite\tI-Chemical\nin\tO\ncombination\tO\nwith\tO\nquinacrine\tB-Chemical\nhydrochloride\tI-Chemical\nappeared\tO\nto\tO\nhave\tO\nno\tO\nadditional\tO\neffect\tO\n.\tO\n\nAlternating\tB-Disease\nsinus\tI-Disease\nrhythm\tI-Disease\nand\tO\nintermittent\tO\nsinoatrial\tB-Disease\nblock\tI-Disease\ninduced\tO\nby\tO\npropranolol\tB-Chemical\n.\tO\n\nAlternating\tB-Disease\nsinus\tI-Disease\nrhythm\tI-Disease\nand\tO\nintermittent\tO\nsinoatrial\tB-Disease\n(\tI-Disease\nS\tI-Disease\n-\tI-Disease\nA\tI-Disease\n)\tI-Disease\nblock\tI-Disease\nwas\tO\nobserved\tO\nin\tO\na\tO\n57\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\n,\tO\nunder\tO\ntreatment\tO\nfor\tO\nangina\tB-Disease\nwith\tO\n80\tO\nmg\tO\npropranolol\tB-Chemical\ndaily\tO\n.\tO\n\nThe\tO\nelectrocardiogram\tO\nshowed\tO\nalternation\tO\nof\tO\nlong\tO\nand\tO\nshort\tO\nP\tO\n-\tO\nP\tO\nintervals\tO\nand\tO\noccasional\tO\npauses\tO\n.\tO\n\nThese\tO\npauses\tO\nwere\tO\nalways\tO\npreceded\tO\nby\tO\nthe\tO\nshort\tO\nP\tO\n-\tO\nP\tO\nintervals\tO\nand\tO\nwere\tO\nusually\tO\nfollowed\tO\nby\tO\none\tO\nor\tO\ntwo\tO\nP\tO\n-\tO\nP\tO\nintervals\tO\nof\tO\n0\tO\n.\tO\n92\tO\n-\tO\n0\tO\n.\tO\n95\tO\ns\tO\nrepresenting\tO\nthe\tO\nbasic\tO\nsinus\tO\ncycle\tO\n.\tO\n\nFollowing\tO\nthese\tO\nbasic\tO\nsinus\tO\ncycles\tO\n,\tO\nalternating\tB-Disease\nrhythm\tI-Disease\nstarted\tO\nwith\tO\nthe\tO\nlonger\tO\nP\tO\n-\tO\nP\tO\ninterval\tO\n.\tO\n\nThe\tO\nlong\tO\nP\tO\n-\tO\nP\tO\nintervals\tO\nranged\tO\nbetween\tO\n1\tO\n.\tO\n04\tO\n-\tO\n1\tO\n.\tO\n12\tO\ns\tO\nand\tO\nthe\tO\nshort\tO\nP\tO\n-\tO\nP\tO\nintervals\tO\nbetween\tO\n0\tO\n.\tO\n80\tO\n-\tO\n0\tO\n.\tO\n84\tO\ns\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nduration\tO\nof\tO\nthe\tO\npauses\tO\nwere\tO\nequal\tO\nor\tO\nalmost\tO\nequal\tO\nto\tO\none\tO\nshort\tO\nplus\tO\none\tO\nlong\tO\nP\tO\n-\tO\nP\tO\ninterval\tO\nor\tO\nto\tO\ntwice\tO\nthe\tO\nbasic\tO\nsinus\tO\ncycle\tO\n.\tO\n\nIn\tO\none\tO\nrecording\tO\na\tO\nshort\tO\nperiod\tO\nof\tO\nregular\tO\nsinus\tO\nrhythm\tO\nwith\tO\nintermittent\tO\n2\tO\n/\tO\n1\tO\nS\tB-Disease\n-\tI-Disease\nA\tI-Disease\nblock\tI-Disease\nwas\tO\nobserved\tO\n.\tO\n\nThis\tO\nshort\tO\nperiod\tO\nof\tO\nsinus\tO\nrhythm\tO\nwas\tO\ninterrupted\tO\nby\tO\nsudden\tO\nprolongation\tO\nof\tO\nthe\tO\nP\tO\n-\tO\nP\tO\ninterval\tO\nstarting\tO\nthe\tO\nalternative\tO\nrhythm\tO\n.\tO\n\nThere\tO\nwere\tO\nsmall\tO\nchanges\tO\nin\tO\nthe\tO\nshape\tO\nof\tO\nthe\tO\nP\tO\nwaves\tO\nand\tO\nP\tO\n-\tO\nR\tO\nintervals\tO\n.\tO\n\nS\tO\n-\tO\nA\tO\nconduction\tO\nthrough\tO\ntwo\tO\npathways\tO\n,\tO\nthe\tO\nfirst\tO\nwith\tO\n2\tO\n/\tO\n1\tO\nblock\tO\nthe\tO\nsecond\tO\nhaving\tO\n0\tO\n.\tO\n12\tO\n-\tO\n0\tO\n.\tO\n14\tO\ns\tO\nlonger\tO\nconduction\tO\ntime\tO\nand\tO\nwith\tO\noccasional\tO\n2\tO\n/\tO\n1\tO\nblock\tO\nwas\tO\nproposed\tO\nfor\tO\nthe\tO\nexplanation\tO\nof\tO\nthe\tO\nalternating\tO\nP\tO\n-\tO\nP\tO\ninterval\tO\nand\tO\nother\tO\nelectrocardiographic\tO\nfeatures\tO\nseen\tO\n.\tO\n\nAtropine\tB-Chemical\n1\tO\nmg\tO\ngiven\tO\nintravenously\tO\nresulted\tO\nin\tO\nshortening\tO\nof\tO\nall\tO\nP\tO\n-\tO\nP\tO\nintervals\tO\nwithout\tO\nchanging\tO\nthe\tO\nrhythm\tO\n.\tO\n\nThe\tO\nabnormal\tO\nrhythm\tO\ndisappeared\tO\nwith\tO\nthe\tO\nwithdrawal\tO\nof\tO\npropranolol\tB-Chemical\nand\tO\nwhen\tO\nthe\tO\ndrug\tO\nwas\tO\nrestarted\tO\na\tO\n2\tO\n/\tO\n1\tO\nS\tB-Disease\n-\tI-Disease\nA\tI-Disease\nblock\tI-Disease\nwas\tO\nseen\tO\n.\tO\n\nThis\tO\nwas\tO\naccepted\tO\nas\tO\nevidence\tO\nfor\tO\npropranolol\tB-Chemical\nbeing\tO\nthe\tO\ncause\tO\nof\tO\nthis\tO\nconduction\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nAntitumor\tO\neffect\tO\n,\tO\ncardiotoxicity\tB-Disease\n,\tO\nand\tO\nnephrotoxicity\tB-Disease\nof\tO\ndoxorubicin\tB-Chemical\nin\tO\nthe\tO\nIgM\tO\nsolid\tO\nimmunocytoma\tB-Disease\n-\tO\nbearing\tO\nLOU\tO\n/\tO\nM\tO\n/\tO\nWSL\tO\nrat\tO\n.\tO\n\nAntitumor\tO\nactivity\tO\n,\tO\ncardiotoxicity\tB-Disease\n,\tO\nand\tO\nnephrotoxicity\tB-Disease\ninduced\tO\nby\tO\ndoxorubicin\tB-Chemical\nwere\tO\nstudied\tO\nin\tO\nLOU\tO\n/\tO\nM\tO\n/\tO\nWSL\tO\ninbred\tO\nrats\tO\neach\tO\nbearing\tO\na\tO\ntransplantable\tO\nsolid\tO\nIgM\tO\nimmunocytoma\tB-Disease\n.\tO\n\nAnimals\tO\nwith\tO\na\tO\ntumor\tB-Disease\n(\tO\ndiameter\tO\n,\tO\n15\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n3\tO\nmm\tO\n)\tO\nwere\tO\ntreated\tO\nwith\tO\niv\tO\ninjections\tO\nof\tO\ndoxorubicin\tB-Chemical\non\tO\n5\tO\nconsecutive\tO\ndays\tO\n,\tO\nfollowed\tO\nby\tO\n1\tO\nweekly\tO\ninjection\tO\nfor\tO\n7\tO\nweeks\tO\n(\tO\ndose\tO\nrange\tO\n,\tO\n0\tO\n.\tO\n015\tO\n-\tO\n4\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nwt\tO\n)\tO\n.\tO\n\nTumor\tB-Disease\nregression\tO\nwas\tO\nobserved\tO\nwith\tO\n0\tO\n.\tO\n5\tO\nmg\tO\ndoxorubicin\tB-Chemical\n/\tO\nkg\tO\n.\tO\n\nComplete\tO\ndisappearance\tO\nof\tO\nthe\tO\ntumor\tB-Disease\nwas\tO\ninduced\tO\nwith\tO\n1\tO\n.\tO\n0\tO\nmg\tO\ndoxorubicin\tB-Chemical\n/\tO\nkg\tO\n.\tO\n\nHistologic\tO\nevidence\tO\nof\tO\ncardiotoxicity\tB-Disease\nscored\tO\nas\tO\ngrade\tO\nIII\tO\nwas\tO\nonly\tO\nobserved\tO\nat\tO\na\tO\ndose\tO\nof\tO\n1\tO\n.\tO\n0\tO\nmg\tO\ndoxorubicin\tB-Chemical\n/\tO\nkg\tO\n.\tO\n\nLight\tO\nmicroscopic\tO\nevidence\tO\nof\tO\nrenal\tB-Disease\ndamage\tI-Disease\nwas\tO\nseen\tO\nabove\tO\na\tO\ndose\tO\nof\tO\n0\tO\n.\tO\n5\tO\nmg\tO\ndoxorubicin\tB-Chemical\n/\tO\nkg\tO\n,\tO\nwhich\tO\nresulted\tO\nin\tO\nalbuminuria\tB-Disease\nand\tO\nvery\tO\nlow\tO\nserum\tO\nalbumin\tO\nlevels\tO\n.\tO\n\nIn\tO\nthe\tO\ngroup\tO\nthat\tO\nreceived\tO\n1\tO\n.\tO\n0\tO\nmg\tO\ndoxorubicin\tB-Chemical\n/\tO\nkg\tO\n,\tO\nthe\tO\nserum\tO\nalbumin\tO\nlevel\tO\ndecreased\tO\nfrom\tO\n33\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n1\tO\nto\tO\n1\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n5\tO\ng\tO\n/\tO\nliter\tO\n.\tO\n\nAscites\tB-Disease\nand\tO\nhydrothorax\tB-Disease\nwere\tO\nobserved\tO\nsimultaneously\tO\n.\tO\n\nThe\tO\nsame\tO\nexperiments\tO\nwere\tO\nperformed\tO\nwith\tO\nnon\tO\n-\tO\ntumor\tB-Disease\n-\tO\nbearing\tO\nrats\tO\n,\tO\nin\tO\nwhich\tO\nno\tO\nmajor\tO\ndifferences\tO\nwere\tO\nobserved\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nantitumor\tO\nactivity\tO\n,\tO\ncardiotoxicity\tB-Disease\n,\tO\nand\tO\nnephrotoxicity\tB-Disease\nwere\tO\nstudied\tO\nsimultaneously\tO\nin\tO\nthe\tO\nsame\tO\nLOU\tO\n/\tO\nM\tO\n/\tO\nWSL\tO\nrat\tO\n.\tO\n\nAlbuminuria\tB-Disease\ndue\tO\nto\tO\nrenal\tB-Disease\ndamage\tI-Disease\nled\tO\nto\tO\nextremely\tO\nlow\tO\nserum\tO\nalbumin\tO\nlevels\tO\n,\tO\nso\tO\nascites\tB-Disease\nand\tO\nhydrothorax\tB-Disease\nwere\tO\nnot\tO\nnecessarily\tO\na\tO\nconsequence\tO\nof\tO\nthe\tO\nobserved\tO\ncardiomyopathy\tB-Disease\n.\tO\n\nIntraoperative\tO\nbradycardia\tB-Disease\nand\tO\nhypotension\tB-Disease\nassociated\tO\nwith\tO\ntimolol\tB-Chemical\nand\tO\npilocarpine\tB-Chemical\neye\tO\ndrops\tO\n.\tO\n\nA\tO\n69\tO\n-\tO\nyr\tO\n-\tO\nold\tO\nman\tO\n,\tO\nwho\tO\nwas\tO\nconcurrently\tO\nbeing\tO\ntreated\tO\nwith\tO\npilocarpine\tB-Chemical\nnitrate\tI-Chemical\nand\tO\ntimolol\tB-Chemical\nmaleate\tI-Chemical\neye\tO\ndrops\tO\n,\tO\ndeveloped\tO\na\tO\nbradycardia\tB-Disease\nand\tO\nbecame\tO\nhypotensive\tB-Disease\nduring\tO\nhalothane\tB-Chemical\nanaesthesia\tO\n.\tO\n\nBoth\tO\ntimolol\tB-Chemical\nand\tO\npilocarpine\tB-Chemical\nwere\tO\nsubsequently\tO\nidentified\tO\nin\tO\na\tO\n24\tO\n-\tO\nh\tO\ncollection\tO\nof\tO\nurine\tO\n.\tO\n\nTimolol\tB-Chemical\n(\tO\nbut\tO\nnot\tO\npilocarpine\tB-Chemical\n)\tO\nwas\tO\ndetected\tO\nin\tO\na\tO\nsample\tO\nof\tO\nplasma\tO\nremoved\tO\nduring\tO\nsurgery\tO\n;\tO\nthe\tO\nplasma\tO\nconcentration\tO\nof\tO\ntimolol\tB-Chemical\n(\tO\n2\tO\n.\tO\n6\tO\nng\tO\nml\tO\n-\tO\n1\tO\n)\tO\nwas\tO\nconsistent\tO\nwith\tO\npartial\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\nblockade\tO\n.\tO\n\nIt\tO\nis\tO\npostulated\tO\nthat\tO\nthis\tO\naction\tO\nmay\tO\nhave\tO\nbeen\tO\nenhanced\tO\nduring\tO\nhalothane\tB-Chemical\nanaesthesia\tO\nwith\tO\nresultant\tO\nbradycardia\tB-Disease\nand\tO\nhypotension\tB-Disease\n.\tO\n\nPilocarpine\tB-Chemical\nmay\tO\nhave\tO\nhad\tO\na\tO\ncontributory\tO\neffect\tO\n.\tO\n\nSuccinylcholine\tB-Chemical\napnoea\tB-Disease\n:\tO\nattempted\tO\nreversal\tO\nwith\tO\nanticholinesterases\tO\n.\tO\n\nAnticholinesterases\tO\nwere\tO\nadministered\tO\nin\tO\nan\tO\nattempt\tO\nto\tO\nantagonize\tO\nprolonged\tO\nneuromuscular\tB-Disease\nblockade\tI-Disease\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nsuccinylcholine\tB-Chemical\nin\tO\na\tO\npatient\tO\nlater\tO\nfound\tO\nto\tO\nbe\tO\nhomozygous\tO\nfor\tO\natypical\tO\nplasma\tO\ncholinesterase\tO\n.\tO\n\nEdrophonium\tB-Chemical\n10\tO\nmg\tO\n,\tO\ngiven\tO\n74\tO\nmin\tO\nafter\tO\nsuccinylcholine\tB-Chemical\n,\tO\nwhen\tO\ntrain\tO\n-\tO\nof\tO\n-\tO\nfour\tO\nstimulation\tO\nwas\tO\ncharacteristic\tO\nof\tO\nphase\tO\nII\tO\nblock\tO\n,\tO\nproduced\tO\npartial\tO\nantagonism\tO\nwhich\tO\nwas\tO\nnot\tO\nsustained\tO\n.\tO\n\nRepeated\tO\ndoses\tO\nof\tO\nedrophonium\tB-Chemical\nto\tO\n70\tO\nmg\tO\nand\tO\nneostigmine\tB-Chemical\nto\tO\n2\tO\n.\tO\n5\tO\nmg\tO\ndid\tO\nnot\tO\nantagonize\tO\nor\tO\naugment\tO\nthe\tO\nblock\tO\n.\tO\n\nSpontaneous\tO\nrespiration\tO\nrecommenced\tO\n200\tO\nmin\tO\nafter\tO\nsuccinylcholine\tB-Chemical\nadministration\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nanticholinesterases\tO\nare\tO\nonly\tO\npartially\tO\neffective\tO\nin\tO\nrestoring\tO\nneuromuscular\tO\nfunction\tO\nin\tO\nsuccinylcholine\tB-Chemical\napnoea\tB-Disease\ndespite\tO\nmuscle\tO\ntwitch\tO\nactivity\tO\ntypical\tO\nof\tO\nphase\tO\nII\tO\nblock\tO\n.\tO\n\nEffect\tO\nof\tO\ndoxorubicin\tB-Chemical\non\tO\n[\tB-Chemical\nomega\tI-Chemical\n-\tI-Chemical\nI\tI-Chemical\n-\tI-Chemical\n131\tI-Chemical\n]\tI-Chemical\nheptadecanoic\tI-Chemical\nacid\tI-Chemical\nmyocardial\tO\nscintigraphy\tO\nand\tO\nechocardiography\tO\nin\tO\ndogs\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nserial\tO\ntreatment\tO\nwith\tO\ndoxorubicin\tB-Chemical\non\tO\ndynamic\tO\nmyocardial\tO\nscintigraphy\tO\nwith\tO\n[\tB-Chemical\nomega\tI-Chemical\n-\tI-Chemical\nI\tI-Chemical\n-\tI-Chemical\n131\tI-Chemical\n]\tI-Chemical\nheptadecanoic\tI-Chemical\nacid\tI-Chemical\n(\tO\nI\tB-Chemical\n-\tI-Chemical\n131\tI-Chemical\nHA\tI-Chemical\n)\tO\n,\tO\nand\tO\non\tO\nglobal\tO\nleft\tO\n-\tO\nventricular\tO\nfunction\tO\ndetermined\tO\nechocardiographically\tO\n,\tO\nwere\tO\nstudied\tO\nin\tO\na\tO\ngroup\tO\nof\tO\nnine\tO\nmongrel\tO\ndogs\tO\n.\tO\n\nTotal\tO\nextractable\tO\nmyocardial\tO\nlipid\tO\nwas\tO\ncompared\tO\npostmortem\tO\nbetween\tO\na\tO\ngroup\tO\nof\tO\ncontrol\tO\ndogs\tO\nand\tO\ndoxorubicin\tB-Chemical\n-\tO\ntreated\tO\ndogs\tO\n.\tO\n\nA\tO\nsignificant\tO\nand\tO\nthen\tO\nprogressive\tO\nfall\tO\nin\tO\nglobal\tO\nLV\tO\nfunction\tO\nwas\tO\nobserved\tO\nat\tO\na\tO\ncumulative\tO\ndoxorubicin\tB-Chemical\ndose\tO\nof\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nA\tO\nsignificant\tO\nincrease\tO\nin\tO\nthe\tO\nmyocardial\tO\nt1\tO\n/\tO\n2\tO\nof\tO\nthe\tO\nI\tB-Chemical\n-\tI-Chemical\n131\tI-Chemical\nHA\tI-Chemical\nwas\tO\nobserved\tO\nonly\tO\nat\tO\na\tO\nhigher\tO\ncumulative\tO\ndose\tO\n,\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nNo\tO\nsignificant\tO\nalteration\tO\nin\tO\ntotal\tO\nextractable\tO\nmyocardial\tO\nlipids\tO\nwas\tO\nobserved\tO\nbetween\tO\ncontrol\tO\ndogs\tO\nand\tO\nthose\tO\ntreated\tO\nwith\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nOur\tO\nfindings\tO\nsuggest\tO\nthat\tO\nthe\tO\nchanges\tO\nleading\tO\nto\tO\nan\tO\nalteration\tO\nof\tO\nmyocardial\tO\ndynamic\tO\nimaging\tO\nwith\tO\nI\tB-Chemical\n-\tI-Chemical\n131\tI-Chemical\nHA\tI-Chemical\nare\tO\nnot\tO\nthe\tO\ninitiating\tO\nfactor\tO\nin\tO\ndoxorubicin\tB-Chemical\ncardiotoxicity\tB-Disease\n.\tO\n\nHemodynamics\tO\nand\tO\nmyocardial\tO\nmetabolism\tO\nunder\tO\ndeliberate\tO\nhypotension\tB-Disease\n.\tO\n\nAn\tO\nexperimental\tO\nstudy\tO\nin\tO\ndogs\tO\n.\tO\n\nCoronary\tO\nblood\tO\nflow\tO\n,\tO\ncardiac\tO\nwork\tO\nand\tO\nmetabolism\tO\nwere\tO\nstudied\tO\nin\tO\ndogs\tO\nunder\tO\nsodium\tB-Chemical\nnitroprusside\tI-Chemical\n(\tO\nSNP\tB-Chemical\n)\tO\nand\tO\ntrimetaphan\tB-Chemical\n(\tO\nTMP\tB-Chemical\n)\tO\ndeliberate\tO\nhypotension\tB-Disease\n(\tO\n20\tO\n%\tO\nand\tO\n40\tO\n%\tO\nmean\tO\npressure\tO\ndecrease\tO\nfrom\tO\nbaseline\tO\n)\tO\n.\tO\n\nRegarding\tO\nthe\tO\neffects\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\non\tO\ncoronary\tO\nblood\tO\nflow\tO\n,\tO\naortic\tO\nand\tO\ncoronary\tO\nsinus\tO\nmetabolic\tO\ndata\tO\n(\tO\npH\tO\n,\tO\npO2\tO\n,\tO\npCO2\tO\n)\tO\nwe\tO\ncould\tO\nconfirm\tO\nthat\tO\nnitroprusside\tB-Chemical\nhypotension\tB-Disease\ncould\tO\nbe\tO\nsafely\tO\nused\tO\nto\tO\n30\tO\n%\tO\nmean\tO\nblood\tO\npressure\tO\ndecrease\tO\nfrom\tO\ncontrol\tO\n,\tO\ntrimetaphan\tB-Chemical\nhypotension\tB-Disease\nto\tO\n20\tO\n%\tO\nmean\tO\nblood\tO\npressure\tO\ndecrease\tO\n.\tO\n\nCardiac\tO\nwork\tO\nwas\tO\nsignificantly\tO\nreduced\tO\nduring\tO\nSNP\tB-Chemical\nhypotension\tB-Disease\n.\tO\n\nMyocardial\tO\nO2\tB-Chemical\nconsumption\tO\nand\tO\nO2\tB-Chemical\navailability\tO\nwere\tO\ndirectly\tO\ndependent\tO\non\tO\nthe\tO\ncoronary\tO\nperfusion\tO\n.\tO\n\nCareful\tO\ninvasive\tO\nmonitoring\tO\nof\tO\nthe\tO\nblood\tO\npressure\tO\n,\tO\nblood\tO\ngases\tO\nand\tO\nof\tO\nthe\tO\nECG\tO\nST\tO\n-\tO\nT\tO\nsegment\tO\nis\tO\nmandatory\tO\n.\tO\n\nEvidence\tO\nfor\tO\na\tO\nselective\tO\nbrain\tO\nnoradrenergic\tO\ninvolvement\tO\nin\tO\nthe\tO\nlocomotor\tO\nstimulant\tO\neffects\tO\nof\tO\namphetamine\tB-Chemical\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nMale\tO\nrats\tO\nreceived\tO\nthe\tO\nnoradrenaline\tB-Chemical\nneurotoxin\tO\nDSP4\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n7\tO\ndays\tO\nprior\tO\nto\tO\ninjection\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\namphetamine\tI-Chemical\n(\tO\n10\tO\nor\tO\n40\tO\nmumol\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nThe\tO\nhyperactivity\tB-Disease\ninduced\tO\nby\tO\nD\tB-Chemical\n-\tI-Chemical\namphetamine\tI-Chemical\n(\tO\n10\tO\nmumol\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\nsignificantly\tO\nreduced\tO\nby\tO\nDSP4\tB-Chemical\npretreatment\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nincreased\tO\nrearings\tO\nand\tO\nthe\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nstereotypies\tB-Disease\nwere\tO\nnot\tO\nblocked\tO\nby\tO\npretreatment\tO\nwith\tO\nDSP4\tB-Chemical\n.\tO\n\nThe\tO\nreduction\tO\nof\tO\namphetamine\tB-Chemical\nhyperactivity\tB-Disease\ninduced\tO\nby\tO\nDSP4\tB-Chemical\nwas\tO\nblocked\tO\nby\tO\npretreatment\tO\nwith\tO\nthe\tO\nnoradrenaline\tB-Chemical\n-\tO\nuptake\tO\nblocking\tO\nagent\tO\n,\tO\ndesipramine\tB-Chemical\n,\tO\nwhich\tO\nprevents\tO\nthe\tO\nneurotoxic\tB-Disease\naction\tO\nof\tO\nDSP4\tB-Chemical\n.\tO\n\nThe\tO\npresent\tO\nresults\tO\nsuggest\tO\na\tO\nselective\tO\ninvolvement\tO\nof\tO\ncentral\tO\nnoradrenergic\tO\nneurones\tO\nin\tO\nthe\tO\nlocomotor\tO\nstimulant\tO\neffect\tO\nof\tO\namphetamine\tB-Chemical\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nAccelerated\tB-Disease\njunctional\tI-Disease\nrhythms\tI-Disease\nduring\tO\noral\tO\nverapamil\tB-Chemical\ntherapy\tO\n.\tO\n\nThis\tO\nstudy\tO\nexamined\tO\nthe\tO\nfrequency\tO\nof\tO\natrioventricular\tO\n(\tO\nAV\tO\n)\tO\ndissociation\tO\nand\tO\naccelerated\tB-Disease\njunctional\tI-Disease\nrhythms\tI-Disease\nin\tO\n59\tO\npatients\tO\nreceiving\tO\noral\tO\nverapamil\tB-Chemical\n.\tO\n\nAccelerated\tB-Disease\njunctional\tI-Disease\nrhythms\tI-Disease\nand\tO\nAV\tO\ndissociation\tO\nwere\tO\nfrequent\tO\nin\tO\npatients\tO\nwith\tO\nsupraventricular\tB-Disease\ntachyarrhythmias\tI-Disease\n,\tO\nparticularly\tO\nAV\tO\nnodal\tO\nreentry\tO\n.\tO\n\nVerapamil\tB-Chemical\nadministration\tO\nto\tO\nthese\tO\npatients\tO\nled\tO\nto\tO\nan\tO\nasymptomatic\tO\nincrease\tO\nin\tO\nactivity\tO\nof\tO\nthese\tO\njunctional\tO\npacemakers\tO\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\nvarious\tO\nchest\tB-Disease\npain\tI-Disease\nsyndromes\tO\n,\tO\nverapamil\tB-Chemical\nneither\tO\nincreased\tO\nthe\tO\nfrequency\tO\nof\tO\njunctional\tO\nrhythms\tO\nnor\tO\nsuppressed\tO\ntheir\tO\nrole\tO\nas\tO\nescape\tO\nrhythms\tO\nunder\tO\nphysiologically\tO\nappropriate\tO\ncircumstances\tO\n.\tO\n\nInterstrain\tO\nvariation\tO\nin\tO\nacute\tO\ntoxic\tO\nresponse\tO\nto\tO\ncaffeine\tB-Chemical\namong\tO\ninbred\tO\nmice\tO\n.\tO\n\nAcute\tO\ntoxic\tO\ndosage\tO\n-\tO\ndependent\tO\nbehavioral\tO\neffects\tO\nof\tO\ncaffeine\tB-Chemical\nwere\tO\ncompared\tO\nin\tO\nadult\tO\nmales\tO\nfrom\tO\nseven\tO\ninbred\tO\nmouse\tO\nstrains\tO\n(\tO\nA\tO\n/\tO\nJ\tO\n,\tO\nBALB\tO\n/\tO\ncJ\tO\n,\tO\nCBA\tO\n/\tO\nJ\tO\n,\tO\nC3H\tO\n/\tO\nHeJ\tO\n,\tO\nC57BL\tO\n/\tO\n6J\tO\n,\tO\nDBA\tO\n/\tO\n2J\tO\n,\tO\nSWR\tO\n/\tO\nJ\tO\n)\tO\n.\tO\n\nC57BL\tO\n/\tO\n6J\tO\n,\tO\nchosen\tO\nas\tO\na\tO\n\"\tO\nprototypic\tO\n\"\tO\nmouse\tO\nstrain\tO\n,\tO\nwas\tO\nused\tO\nto\tO\ndetermine\tO\nbehavioral\tO\nresponses\tO\nto\tO\na\tO\nbroad\tO\nrange\tO\n(\tO\n5\tO\n-\tO\n500\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nof\tO\ncaffeine\tB-Chemical\ndoses\tO\n.\tO\n\nFive\tO\nphenotypic\tO\ncharacteristics\tO\n-\tO\n-\tO\nlocomotor\tO\nactivity\tO\n,\tO\nrighting\tO\nability\tO\n,\tO\nclonic\tB-Disease\nseizure\tI-Disease\ninduction\tO\n,\tO\nstress\tO\n-\tO\ninduced\tO\nlethality\tO\n,\tO\ndeath\tO\nwithout\tO\nexternal\tO\nstress\tO\n-\tO\n-\tO\nwere\tO\nscored\tO\nat\tO\nvarious\tO\ncaffeine\tB-Chemical\ndoses\tO\nin\tO\ndrug\tO\n-\tO\nnaive\tO\nanimals\tO\nunder\tO\nempirically\tO\noptimized\tO\n,\tO\nrigidly\tO\nconstant\tO\nexperimental\tO\nconditions\tO\n.\tO\n\nMice\tO\n(\tO\nn\tO\n=\tO\n12\tO\nfor\tO\neach\tO\npoint\tO\n)\tO\nreceived\tO\nsingle\tO\nIP\tO\ninjections\tO\nof\tO\na\tO\nfixed\tO\nvolume\tO\n/\tO\ng\tO\nbody\tO\nweight\tO\nof\tO\nphysiological\tO\nsaline\tO\ncarrier\tO\nwith\tO\nor\tO\nwithout\tO\ncaffeine\tB-Chemical\nin\tO\ndoses\tO\nranging\tO\nfrom\tO\n125\tO\n-\tO\n500\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nLoss\tO\nof\tO\nrighting\tO\nability\tO\nwas\tO\nscored\tO\nat\tO\n1\tO\n,\tO\n3\tO\n,\tO\n5\tO\nmin\tO\npost\tO\ndosing\tO\nand\tO\nat\tO\n5\tO\nmin\tO\nintervals\tO\nthereafter\tO\nfor\tO\n20\tO\nmin\tO\n.\tO\n\nIn\tO\nthe\tO\nsame\tO\nanimals\tO\nthe\tO\noccurrence\tO\nof\tO\nclonic\tB-Disease\nseizures\tI-Disease\nwas\tO\nscored\tO\nas\tO\nto\tO\ntime\tO\nof\tO\nonset\tO\nand\tO\nseverity\tO\nfor\tO\n20\tO\nmin\tO\nafter\tO\ndrug\tO\nadministration\tO\n.\tO\n\nWhen\tO\nthese\tO\nproceeded\tO\nto\tO\ntonic\tB-Disease\nseizures\tI-Disease\n,\tO\ndeath\tO\noccurred\tO\nin\tO\nless\tO\nthan\tO\n20\tO\nmin\tO\n.\tO\n\nAnimals\tO\nsurviving\tO\nfor\tO\n20\tO\nmin\tO\nwere\tO\nimmediately\tO\nstressed\tO\nby\tO\na\tO\nswim\tO\ntest\tO\nin\tO\n25\tO\ndegrees\tO\nC\tO\nwater\tO\n,\tO\nand\tO\ndeath\tO\n-\tO\nproducing\tO\ntonic\tB-Disease\nseizures\tI-Disease\nwere\tO\nscored\tO\nfor\tO\n2\tO\nmin\tO\n.\tO\n\nIn\tO\nother\tO\nanimals\tO\nlocomotor\tO\nactivity\tO\nwas\tO\nmeasured\tO\n15\tO\nor\tO\n60\tO\nmin\tO\nafter\tO\ncaffeine\tB-Chemical\nadministration\tO\n.\tO\n\nBy\tO\nany\tO\nsingle\tO\nbehavioral\tO\ncriterion\tO\nor\tO\na\tO\ncombination\tO\nof\tO\nthese\tO\ncriteria\tO\n,\tO\nmarked\tO\ndifferences\tO\nin\tO\nresponse\tO\nto\tO\ntoxic\tO\ncaffeine\tB-Chemical\ndoses\tO\nwere\tO\nobserved\tO\nbetween\tO\nstrains\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nbehavioral\tO\ntoxicity\tB-Disease\ntesting\tO\nof\tO\nalkylxanthines\tB-Chemical\nin\tO\na\tO\nsingle\tO\nmouse\tO\nstrain\tO\nmay\tO\nbe\tO\nmisleading\tO\nand\tO\nsuggest\tO\nthat\tO\ntoxic\tO\nresponses\tO\nof\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\nto\tO\nthis\tO\nclass\tO\nof\tO\ncompounds\tO\nare\tO\ngenetically\tO\ninfluenced\tO\nin\tO\nmammals\tO\n.\tO\n\nTreatment\tO\nof\tO\novarian\tB-Disease\ncancer\tI-Disease\nwith\tO\na\tO\ncombination\tO\nof\tO\ncis\tB-Chemical\n-\tI-Chemical\nplatinum\tI-Chemical\n,\tO\nadriamycin\tB-Chemical\n,\tO\ncyclophosphamide\tB-Chemical\nand\tO\nhexamethylmelamine\tB-Chemical\n.\tO\n\nDuring\tO\nthe\tO\nlast\tO\n2\tO\n1\tO\n/\tO\n2\tO\nyears\tO\n,\tO\n38\tO\npatients\tO\nwith\tO\novarian\tB-Disease\ncancer\tI-Disease\nwere\tO\ntreated\tO\nwith\tO\na\tO\ncombination\tO\nof\tO\ncisplatinum\tB-Chemical\n(\tO\nCPDD\tB-Chemical\n)\tO\n,\tO\n50\tO\nmg\tO\n/\tO\nm2\tO\n,\tO\nadriamycin\tB-Chemical\n,\tO\n30\tO\nmg\tO\n/\tO\nm2\tO\n,\tO\ncyclophosphamide\tB-Chemical\n,\tO\n300\tO\nmg\tO\n/\tO\nm2\tO\n,\tO\non\tO\nday\tO\n1\tO\n;\tO\nand\tO\nhexamethylmelamine\tB-Chemical\n(\tO\nHMM\tB-Chemical\n)\tO\n,\tO\n6\tO\nmg\tO\n/\tO\nkg\tO\ndaily\tO\n,\tO\nfor\tO\n14\tO\ndays\tO\n.\tO\n\nEach\tO\ncourse\tO\nwas\tO\nrepeated\tO\nmonthly\tO\n.\tO\n\n2\tO\npatients\tO\nhad\tO\nstage\tO\nII\tO\n,\tO\n14\tO\nstage\tO\nIII\tO\nand\tO\n22\tO\nstage\tO\nIV\tO\ndisease\tO\n.\tO\n\n14\tO\nof\tO\nthe\tO\n38\tO\npatients\tO\nwere\tO\npreviously\tO\ntreated\tO\nwith\tO\nchemotherapy\tO\n,\tO\n1\tO\nwith\tO\nradiation\tO\n,\tO\n6\tO\nwith\tO\nboth\tO\nchemotherapy\tO\nand\tO\nradiation\tO\n,\tO\nand\tO\n17\tO\ndid\tO\nnot\tO\nhave\tO\nany\tO\ntreatment\tO\nbefore\tO\nCPDD\tB-Chemical\ncombination\tO\n.\tO\n\n31\tO\nof\tO\nthe\tO\n38\tO\ncases\tO\n(\tO\n81\tO\n.\tO\n5\tO\n%\tO\n)\tO\ndemonstrated\tO\nobjective\tO\nresponses\tO\nlasting\tO\nfor\tO\n2\tO\nmonths\tO\nor\tO\nmore\tO\n.\tO\n\nThese\tO\nresponses\tO\nwere\tO\npartial\tO\nin\tO\n19\tO\nand\tO\ncomplete\tO\nin\tO\n12\tO\ncases\tO\n.\tO\n\nHematologic\tB-Disease\ntoxicity\tI-Disease\nwas\tO\nmoderate\tO\nand\tO\nwith\tO\nreversible\tO\nanemia\tB-Disease\ndeveloping\tO\nin\tO\n71\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nGastrointestinal\tO\nside\tO\neffects\tO\nfrom\tO\nCPDD\tB-Chemical\nwere\tO\nuniversal\tO\n.\tO\n\nHMM\tB-Chemical\ngastrointestinal\tB-Disease\ntoxicity\tI-Disease\nnecessitated\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nin\tO\n5\tO\npatients\tO\n.\tO\n\nSevere\tO\nnephrotoxicity\tB-Disease\nwas\tO\nobserved\tO\nin\tO\n2\tO\npatients\tO\nbut\tO\nwas\tO\nreversible\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\ndrug\tO\n-\tO\nrelated\tO\ndeaths\tO\n.\tO\n\nNontraumatic\tO\ndissecting\tB-Disease\naneurysm\tI-Disease\nof\tO\nthe\tO\nbasilar\tO\nartery\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nnontraumatic\tO\ndissecting\tB-Disease\naneurysm\tI-Disease\nof\tO\nthe\tO\nbasilar\tO\nartery\tO\nin\tO\nassociation\tO\nwith\tO\nhypertension\tB-Disease\n,\tO\nsmoke\tO\n,\tO\nand\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nis\tO\nreported\tO\nin\tO\na\tO\nyoung\tO\nfemale\tO\npatient\tO\nwith\tO\na\tO\nlocked\tB-Disease\n-\tI-Disease\nin\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nA\tO\nmethod\tO\nfor\tO\nthe\tO\nmeasurement\tO\nof\tO\ntremor\tB-Disease\n,\tO\nand\tO\na\tO\ncomparison\tO\nof\tO\nthe\tO\neffects\tO\nof\tO\ntocolytic\tO\nbeta\tO\n-\tO\nmimetics\tO\n.\tO\n\nA\tO\nmethod\tO\npermitting\tO\nmeasurement\tO\nof\tO\nfinger\tO\ntremor\tB-Disease\nas\tO\na\tO\ndisplacement\tO\n-\tO\ntime\tO\ncurve\tO\nis\tO\ndescribed\tO\n,\tO\nusing\tO\na\tO\ntest\tO\nsystem\tO\nwith\tO\nsimple\tO\namplitude\tO\ncalibration\tO\n.\tO\n\nThe\tO\ncoordinates\tO\nof\tO\nthe\tO\ninversion\tO\npoints\tO\nof\tO\nthe\tO\ndisplacement\tO\n-\tO\ntime\tO\ncurves\tO\nwere\tO\ntransferred\tO\nthrough\tO\ngraphical\tO\ninput\tO\nequipment\tO\nto\tO\npunched\tO\ntape\tO\n.\tO\n\nBy\tO\nmeans\tO\nof\tO\na\tO\ncomputer\tO\nprogram\tO\n,\tO\nperiods\tO\nand\tO\namplitudes\tO\nof\tO\ntremor\tB-Disease\noscillations\tO\nwere\tO\ncalculated\tO\nand\tO\nclassified\tO\n.\tO\n\nThe\tO\nevent\tO\nfrequency\tO\nfor\tO\neach\tO\nclass\tO\nof\tO\nperiods\tO\nand\tO\namplitudes\tO\nwas\tO\ndetermined\tO\n.\tO\n\nThe\tO\nactions\tO\nof\tO\nfenoterol\tB-Chemical\n-\tI-Chemical\nhydrobromide\tI-Chemical\n,\tO\nritodrin\tB-Chemical\n-\tI-Chemical\nHCl\tI-Chemical\nand\tO\nplacebo\tO\ngiven\tO\nto\tO\n10\tO\nhealthy\tO\nsubjects\tO\nby\tO\nintravenous\tO\ninfusion\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\ncrossover\tO\nstudy\tO\nwere\tO\ntested\tO\nby\tO\nthis\tO\nmethod\tO\n.\tO\n\nAt\tO\ntherapeutic\tO\ndoses\tO\nboth\tO\nsubstances\tO\nraised\tO\nthe\tO\nmean\tO\ntremor\tB-Disease\namplitude\tO\nto\tO\nabout\tO\nthree\tO\ntimes\tO\nthe\tO\ncontrol\tO\nlevel\tO\n.\tO\n\nAt\tO\nthe\tO\nsame\tO\ntime\tO\n,\tO\nthe\tO\nmean\tO\nperiod\tO\nwithin\tO\neach\tO\nclass\tO\nof\tO\namplitudes\tO\nshortened\tO\nby\tO\n10\tO\n-\tO\n-\tO\n20\tO\nms\tO\n,\tO\nwhereas\tO\nthe\tO\nmean\tO\nperiods\tO\ncalculated\tO\nfrom\tO\nall\tO\noscillations\tO\ntogether\tO\ndid\tO\nnot\tO\nchange\tO\nsignificantly\tO\n.\tO\n\nAfter\tO\nthe\tO\nend\tO\nof\tO\nfenoterol\tB-Chemical\n-\tI-Chemical\nhydrobromide\tI-Chemical\ninfusion\tO\n,\tO\ntremor\tB-Disease\namplitudes\tO\ndecreased\tO\nsignificantly\tO\nfaster\tO\nthan\tO\nthose\tO\nfollowing\tO\nritodrin\tB-Chemical\n-\tI-Chemical\nHCl\tI-Chemical\ninfusion\tO\n.\tO\n\nPropylthiouracil\tB-Chemical\n-\tO\ninduced\tO\nhepatic\tB-Disease\ndamage\tI-Disease\n.\tO\n\nTwo\tO\ncases\tO\nof\tO\npropylthiouracil\tB-Chemical\n-\tO\ninduced\tO\nliver\tB-Disease\ndamage\tI-Disease\nhave\tO\nbeen\tO\nobserved\tO\n.\tO\n\nThe\tO\nfirst\tO\ncase\tO\nis\tO\nof\tO\nan\tO\nacute\tO\ntype\tO\nof\tO\ndamage\tO\n,\tO\nproven\tO\nby\tO\nrechallenge\tO\n;\tO\nthe\tO\nsecond\tO\npresents\tO\na\tO\nclinical\tO\nand\tO\nhistologic\tO\npicture\tO\nresembling\tO\nchronic\tB-Disease\nactive\tI-Disease\nhepatitis\tI-Disease\n,\tO\nwith\tO\nspontaneous\tO\nremission\tO\n.\tO\n\nStudies\tO\non\tO\nthe\tO\nbradycardia\tB-Disease\ninduced\tO\nby\tO\nbepridil\tB-Chemical\n.\tO\n\nBepridil\tB-Chemical\n,\tO\na\tO\nnovel\tO\nactive\tO\ncompound\tO\nfor\tO\nprophylactic\tO\ntreatment\tO\nof\tO\nanginal\tB-Disease\nattacks\tI-Disease\n,\tO\ninduced\tO\npersistent\tO\nbradycardia\tB-Disease\nand\tO\na\tO\nnon\tO\n-\tO\nspecific\tO\nanti\tO\n-\tO\ntachycardial\tB-Disease\neffect\tO\n,\tO\nthe\tO\nmechanisms\tO\nof\tO\nwhich\tO\nwere\tO\ninvestigated\tO\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\n.\tO\n\nIn\tO\nvitro\tO\nperfusion\tO\nof\tO\nbepridil\tB-Chemical\nin\tO\nthe\tO\nlife\tO\n-\tO\nsupport\tO\nmedium\tO\nfor\tO\nisolated\tO\nsino\tO\n-\tO\natrial\tO\ntissue\tO\nfrom\tO\nrabbit\tO\nheart\tO\n,\tO\ncaused\tO\na\tO\nreduction\tO\nin\tO\naction\tO\npotential\tO\n(\tO\nAP\tO\n)\tO\nspike\tO\nfrequency\tO\n(\tO\nrecorded\tO\nby\tO\nKCl\tB-Chemical\nmicroelectrodes\tO\n)\tO\nstarting\tO\nat\tO\ndoses\tO\nof\tO\n5\tO\nX\tO\n10\tO\n(\tO\n-\tO\n6\tO\n)\tO\nM\tO\n.\tO\n\nThis\tO\neffect\tO\nwas\tO\ndose\tO\n-\tO\ndependent\tO\nup\tO\nto\tO\nconcentrations\tO\nof\tO\n5\tO\nX\tO\n10\tO\n(\tO\n-\tO\n5\tO\n)\tO\nM\tO\n,\tO\nwhereupon\tO\nblockade\tO\nof\tO\nsinus\tO\nactivity\tO\nset\tO\nin\tO\n.\tO\n\nBepridil\tB-Chemical\nat\tO\na\tO\ndose\tO\nof\tO\n5\tO\nX\tO\n10\tO\n(\tO\n-\tO\n6\tO\n)\tO\nM\tO\n,\tO\ninduced\tO\na\tO\nconcomitant\tO\nreduction\tO\nin\tO\nAP\tO\namplitude\tO\n(\tO\nfalling\tO\nfrom\tO\n71\tO\n+\tO\n/\tO\n-\tO\n8\tO\nmV\tO\nto\tO\n47\tO\n+\tO\n/\tO\n-\tO\n6\tO\nmV\tO\n)\tO\n,\tO\nmaximum\tO\nsystolic\tO\ndepolarization\tO\nvelocity\tO\n(\tO\nphase\tO\n0\tO\n)\tO\nwhich\tO\nfell\tO\nfrom\tO\n1\tO\n.\tO\n85\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n35\tO\nV\tO\n/\tO\ns\tO\nto\tO\n0\tO\n.\tO\n84\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n28\tO\nV\tO\n/\tO\ns\tO\n,\tO\ntogether\tO\nwith\tO\nmaximum\tO\ndiastolic\tO\ndepolarization\tO\nvelocity\tO\n(\tO\nphase\tO\n4\tO\n)\tO\nwhich\tO\nfell\tO\nfrom\tO\n38\tO\n+\tO\n/\tO\n-\tO\n3\tO\nmV\tO\n/\tO\ns\tO\nto\tO\n24\tO\n+\tO\n/\tO\n-\tO\n5\tO\nmV\tO\n/\tO\ns\tO\n.\tO\n\nIn\tO\nvivo\tO\ninjection\tO\nof\tO\nbepridil\tB-Chemical\nat\tO\na\tO\ndose\tO\nof\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\ninto\tO\n6\tO\nanaesthetized\tO\ndogs\tO\nwhich\tO\nhad\tO\nundergone\tO\nablation\tO\nof\tO\nall\tO\nthe\tO\nextrinsic\tO\ncardiac\tO\nafferent\tO\nnerve\tO\nsupply\tO\n,\tO\ntogether\tO\nwith\tO\na\tO\nbilateral\tO\nmedullo\tO\n-\tO\nadrenalectomy\tO\n,\tO\ncaused\tO\na\tO\nmarked\tO\nreduction\tO\nin\tO\nheart\tO\nrate\tO\nwhich\tO\nfell\tO\nfrom\tO\n98\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n2\tO\nbeats\tO\n/\tO\nmin\tO\nto\tO\n76\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n3\tO\nbeats\tO\n/\tO\nmin\tO\nsustained\tO\nfor\tO\nmore\tO\nthan\tO\n45\tO\nmin\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nbepridil\tB-Chemical\nreduces\tO\nheart\tO\nrate\tO\nby\tO\nacting\tO\ndirectly\tO\non\tO\nthe\tO\nsinus\tO\nnode\tO\n.\tO\n\nThis\tO\neffect\tO\n,\tO\nwhich\tO\nresults\tO\nin\tO\na\tO\nflattening\tO\nof\tO\nthe\tO\nphase\tO\n0\tO\nand\tO\nphase\tO\n4\tO\nslope\tO\n,\tO\ntogether\tO\nwith\tO\na\tO\nlonger\tO\nAP\tO\nduration\tO\n,\tO\nmay\tO\nbe\tO\ndue\tO\nto\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\ntime\tO\nconstants\tO\nof\tO\nslow\tO\ninward\tO\nionic\tO\ncurrents\tO\n(\tO\nalready\tO\ndemonstrated\tO\nelsewhere\tO\n)\tO\n,\tO\nbut\tO\nalso\tO\nto\tO\nan\tO\nincreased\tO\ntime\tO\nconstant\tO\nfor\tO\ndeactivation\tO\nof\tO\nthe\tO\noutward\tO\npotassium\tB-Chemical\ncurrent\tO\n(\tO\nIp\tO\n)\tO\n.\tO\n\nHepatitis\tB-Disease\nand\tO\nrenal\tB-Disease\ntubular\tI-Disease\nacidosis\tI-Disease\nafter\tO\nanesthesia\tO\nwith\tO\nmethoxyflurane\tB-Chemical\n.\tO\n\nA\tO\n69\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\noperated\tO\nfor\tO\nacute\tB-Disease\ncholecystitis\tI-Disease\nunder\tO\nmethoxyflurane\tB-Chemical\nanesthesia\tO\ndeveloped\tO\npostoperatively\tO\na\tO\nhepatic\tB-Disease\ninsufficiency\tI-Disease\nsyndrome\tI-Disease\nand\tO\nrenal\tB-Disease\ntubular\tI-Disease\nacidosis\tI-Disease\n.\tO\n\nMassive\tO\nbleeding\tB-Disease\nappeared\tO\nduring\tO\nsurgery\tO\nwhich\tO\nlasted\tO\nfor\tO\nsix\tO\nhours\tO\n.\tO\n\nPostoperative\tO\nevolution\tO\nunder\tO\nsupportive\tO\ntherapy\tO\nwas\tO\nfavourable\tO\n.\tO\n\nComplete\tO\nrecovery\tO\nwas\tO\nconfirmed\tO\nby\tO\nrepeated\tO\ncontrols\tO\nperformed\tO\nover\tO\na\tO\nperiod\tO\nof\tO\none\tO\nyear\tO\nafter\tO\nsurgery\tO\n.\tO\n\nPituitary\tO\nresponse\tO\nto\tO\nluteinizing\tO\nhormone\tO\n-\tO\nreleasing\tO\nhormone\tO\nduring\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\na\tO\n6\tO\n-\tO\nhour\tO\ninfusion\tO\nwith\tO\nhaloperidol\tB-Chemical\non\tO\nserum\tO\nprolactin\tO\nand\tO\nluteinizing\tO\nhormone\tO\n(\tO\nLH\tO\n)\tO\nlevels\tO\nwas\tO\nstudied\tO\nin\tO\na\tO\ngroup\tO\nof\tO\nmale\tO\nsubjects\tO\n.\tO\n\nFive\tO\nhours\tO\nafter\tO\nstarting\tO\nthe\tO\ninfusions\tO\n,\tO\na\tO\nstudy\tO\nof\tO\nthe\tO\npituitary\tO\nresponses\tO\nto\tO\nLH\tO\n-\tO\nreleasing\tO\nhormone\tO\n(\tO\nLH\tO\n-\tO\nRH\tO\n)\tO\nwas\tO\ncarried\tO\nout\tO\n.\tO\n\nControl\tO\npatients\tO\nreceived\tO\ninfusions\tO\nof\tO\n0\tO\n.\tO\n9\tO\n%\tO\nNaCl\tB-Chemical\nsolution\tO\n.\tO\n\nDuring\tO\nthe\tO\ncourse\tO\nof\tO\nhaloperidol\tB-Chemical\ninfusions\tO\n,\tO\nsignificant\tO\nhyperprolactinemia\tB-Disease\nwas\tO\nfound\tO\n,\tO\ntogether\tO\nwith\tO\nan\tO\nabolished\tO\npituitary\tO\nresponse\tO\nto\tO\nLH\tO\n-\tO\nRH\tO\n,\tO\nas\tO\ncompared\tO\nwith\tO\nresponses\tO\nof\tO\ncontrol\tO\nsubjects\tO\n.\tO\n\nAntirifampicin\tO\nantibodies\tO\nin\tO\nacute\tO\nrifampicin\tB-Chemical\n-\tO\nassociated\tO\nrenal\tB-Disease\nfailure\tI-Disease\n.\tO\n\n5\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n(\tO\n3\tO\nwith\tO\nthrombopenia\tB-Disease\nand\tO\nhemolysis\tB-Disease\n)\tO\ninduced\tO\nby\tO\nthe\tO\nreintroduction\tO\nof\tO\nrifampicin\tB-Chemical\nare\tO\ndescribed\tO\n.\tO\n\nNo\tO\ncorrelation\tO\nwas\tO\nfound\tO\nbetween\tO\nthe\tO\nseverity\tO\nof\tO\nclinical\tO\nmanifestations\tO\nand\tO\nthe\tO\ntotal\tO\ndose\tO\ntaken\tO\nby\tO\nthe\tO\npatients\tO\n.\tO\n\nIn\tO\nall\tO\nbut\tO\n1\tO\npatient\tO\n,\tO\nantirifampicin\tO\nantibodies\tO\nwere\tO\ndetected\tO\n.\tO\n\nAntibodies\tO\nsuggested\tO\nto\tO\nbe\tO\nof\tO\nthe\tO\nIgM\tO\nclass\tO\nwere\tO\ndetected\tO\nin\tO\nall\tO\n3\tO\npatients\tO\nwith\tO\nhematological\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nThe\tO\npattern\tO\nof\tO\nnon\tO\n-\tO\nspecific\tO\nacute\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\nfound\tO\nin\tO\nthe\tO\n2\tO\nbiopsied\tO\npatients\tO\n,\tO\nindistinguishable\tO\nfrom\tO\nthat\tO\nof\tO\nischemic\tO\norigin\tO\n,\tO\nraised\tO\nthe\tO\npossibility\tO\nof\tO\na\tO\nvascular\tO\n-\tO\nmediated\tO\ndamage\tO\n.\tO\n\nIn\tO\n3\tO\npatients\tO\n,\tO\nthe\tO\npossibility\tO\nof\tO\na\tO\ntriggering\tO\nimmunoallergic\tO\nmechanism\tO\nis\tO\ndiscussed\tO\n.\tO\n\nCardiovascular\tO\neffects\tO\nof\tO\nhypotension\tB-Disease\ninduced\tO\nby\tO\nadenosine\tB-Chemical\ntriphosphate\tI-Chemical\nand\tO\nsodium\tB-Chemical\nnitroprusside\tI-Chemical\non\tO\ndogs\tO\nwith\tO\ndenervated\tO\nhearts\tO\n.\tO\n\nAdenosine\tB-Chemical\ntriphosphate\tI-Chemical\n(\tO\nATP\tB-Chemical\n)\tO\nand\tO\nsodium\tB-Chemical\nnitroprusside\tI-Chemical\n(\tO\nSNP\tB-Chemical\n)\tO\nare\tO\nadministered\tO\nto\tO\npatients\tO\nto\tO\ninduce\tO\nand\tO\ncontrol\tO\nhypotension\tB-Disease\nduring\tO\nanesthesia\tO\n.\tO\n\nSNP\tB-Chemical\nis\tO\nauthorized\tO\nfor\tO\nclinical\tO\nuse\tO\nin\tO\nUSA\tO\nand\tO\nUK\tO\n,\tO\nand\tO\nATP\tB-Chemical\nis\tO\nclinically\tO\nused\tO\nin\tO\nother\tO\ncountries\tO\nsuch\tO\nas\tO\nJapan\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nhow\tO\nthese\tO\ntwo\tO\ndrugs\tO\nact\tO\non\tO\nthe\tO\ncardiovascular\tO\nsystems\tO\nof\tO\n20\tO\ndogs\tO\nwhose\tO\nhearts\tO\nhad\tO\nbeen\tO\ndenervated\tO\nby\tO\na\tO\nprocedure\tO\nwe\tO\nhad\tO\ndevised\tO\n.\tO\n\nATP\tB-Chemical\n(\tO\n10\tO\ndogs\tO\n)\tO\nor\tO\nSNP\tB-Chemical\n(\tO\n10\tO\ndogs\tO\n)\tO\nwas\tO\nadministered\tO\nto\tO\nreduce\tO\nmean\tO\narterial\tO\npressure\tO\nby\tO\n30\tO\n%\tO\nto\tO\n70\tO\n%\tO\nof\tO\ncontrol\tO\n.\tO\n\nBefore\tO\n,\tO\nduring\tO\nand\tO\nafter\tO\ninduced\tO\nhypotension\tB-Disease\n,\tO\nwe\tO\nmeasured\tO\nmajor\tO\ncardiovascular\tO\nparameters\tO\n.\tO\n\nHypotension\tB-Disease\ninduced\tO\nby\tO\nATP\tB-Chemical\nwas\tO\naccompanied\tO\nby\tO\nsignificant\tO\ndecreases\tO\nin\tO\nmean\tO\npulmonary\tO\narterial\tO\npressure\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\ncentral\tO\nvenous\tO\npressure\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nleft\tO\nventricular\tO\nend\tO\n-\tO\ndiastolic\tO\npressure\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\ntotal\tO\nperipheral\tO\nresistance\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrate\tO\npressure\tO\nproduct\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\ntotal\tO\nbody\tO\noxygen\tB-Chemical\nconsumption\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nand\tO\nheart\tO\nrate\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n;\tO\nall\tO\nthese\tO\nvariables\tO\nreturned\tO\nnormal\tO\nwithin\tO\n30\tO\nmin\tO\nafter\tO\nATP\tB-Chemical\nwas\tO\nstopped\tO\n.\tO\n\nCardiac\tO\noutput\tO\ndid\tO\nnot\tO\nchange\tO\n.\tO\n\nDuring\tO\nhypotension\tB-Disease\nproduced\tO\nby\tO\nSNP\tB-Chemical\nsimilar\tO\ndecreases\tO\nwere\tO\nobserved\tO\nin\tO\nmean\tO\npulmonary\tO\narterial\tO\npressure\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\ncentral\tO\nvenous\tO\npressure\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nleft\tO\nventricular\tO\nend\tO\n-\tO\ndiastolic\tO\npressure\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\ntotal\tO\nperipheral\tO\nresistance\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrate\tO\npressure\tO\nproduct\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nand\tO\noxygen\tB-Chemical\ncontent\tO\ndifference\tO\nbetween\tO\narterial\tO\nand\tO\nmixed\tO\nvenous\tO\nblood\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nwhile\tO\nheart\tO\nrate\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\ncardiac\tO\noutput\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nwere\tO\nincreased\tO\n.\tO\n\nRecoveries\tO\nof\tO\nheart\tO\nrate\tO\nand\tO\nleft\tO\nventricular\tO\nend\tO\n-\tO\ndiastolic\tO\npressure\tO\nwere\tO\nnot\tO\nshown\tO\nwithin\tO\n60\tO\nmin\tO\nafter\tO\nSNP\tB-Chemical\nhad\tO\nbeen\tO\nstopped\tO\n.\tO\n\nBoth\tO\nATP\tB-Chemical\nand\tO\nSNP\tB-Chemical\nshould\tO\nact\tO\non\tO\nthe\tO\npacemaker\tO\ntissue\tO\nof\tO\nthe\tO\nheart\tO\n.\tO\n\nComparative\tO\nstudy\tO\n:\tO\nEndografine\tB-Chemical\n(\tO\ndiatrizoate\tB-Chemical\n)\tO\n,\tO\nVasurix\tB-Chemical\npolyvidone\tI-Chemical\n(\tO\nacetrizoate\tB-Chemical\n)\tO\n,\tO\nDimer\tB-Chemical\n-\tI-Chemical\nX\tI-Chemical\n(\tO\niocarmate\tB-Chemical\n)\tO\nand\tO\nHexabrix\tB-Chemical\n(\tO\nioxaglate\tB-Chemical\n)\tO\nin\tO\nhysterosalpingography\tO\n.\tO\n\nSide\tO\neffects\tO\nof\tO\nhysterosalpingography\tO\nwith\tO\nDimer\tB-Chemical\n-\tI-Chemical\nX\tI-Chemical\n,\tO\nHexabrix\tB-Chemical\n,\tO\nVasurix\tB-Chemical\npolyvidone\tI-Chemical\nand\tO\nEndografine\tB-Chemical\nin\tO\n142\tO\nconsecutive\tO\npatients\tO\n,\tO\nreceiving\tO\none\tO\nof\tO\nthe\tO\nfour\tO\ntested\tO\nmedia\tO\nwere\tO\nevaluated\tO\nfrom\tO\nreplies\tO\nto\tO\npostal\tO\nquestionnaires\tO\n.\tO\n\nThe\tO\nDimer\tB-Chemical\n-\tI-Chemical\nX\tI-Chemical\ngroup\tO\nhad\tO\na\tO\nhigher\tO\nincidence\tO\nof\tO\nnausea\tB-Disease\nand\tO\ndizziness\tB-Disease\n.\tO\n\nThe\tO\nEndografine\tB-Chemical\ngroup\tO\nhad\tO\na\tO\nhigher\tO\nincidence\tO\nof\tO\nabdominal\tB-Disease\npain\tI-Disease\n.\tO\n\nThese\tO\ndifferences\tO\noccur\tO\nespecially\tO\nin\tO\nthe\tO\nage\tO\ngroups\tO\nunder\tO\n30\tO\nyears\tO\n.\tO\n\nHexabrix\tB-Chemical\nand\tO\nVasurix\tB-Chemical\npolyvidone\tI-Chemical\nare\tO\nconsidered\tO\nthe\tO\nbest\tO\ncontrast\tB-Chemical\nmedia\tI-Chemical\nfor\tO\nhysterosalpingography\tO\nand\tO\nperhaps\tO\nbecause\tO\nof\tO\nits\tO\nlow\tO\ntoxicity\tB-Disease\nHexabrix\tB-Chemical\nshould\tO\nbe\tO\npreferred\tO\n.\tO\n\nPost\tO\n-\tO\nsuxamethonium\tB-Chemical\npains\tB-Disease\nin\tO\nNigerian\tO\nsurgical\tO\npatients\tO\n.\tO\n\nContrary\tO\nto\tO\nan\tO\nearlier\tO\nreport\tO\nby\tO\nCoxon\tO\n,\tO\nscoline\tB-Chemical\npain\tB-Disease\noccurs\tO\nin\tO\nAfrican\tO\nnegroes\tO\n.\tO\n\nIts\tO\nincidence\tO\nwas\tO\ndetermined\tO\nin\tO\na\tO\nprospective\tO\nstudy\tO\ninvolving\tO\na\tO\ntotal\tO\nof\tO\n100\tO\nNigerian\tO\npatients\tO\n(\tO\n50\tO\nout\tO\n-\tO\npatients\tO\nand\tO\n50\tO\nin\tO\n-\tO\npatients\tO\n)\tO\n.\tO\n\nAbout\tO\n62\tO\n%\tO\nof\tO\nthe\tO\nout\tO\n-\tO\npatients\tO\ndeveloped\tO\nscoline\tB-Chemical\npain\tB-Disease\nas\tO\ncompared\tO\nwith\tO\nabout\tO\n26\tO\n%\tO\namong\tO\nthe\tO\nin\tO\n-\tO\npatients\tO\n.\tO\n\nThe\tO\nabolition\tO\nof\tO\nmuscle\tO\nfasciculations\tB-Disease\n(\tO\nby\tO\n0\tO\n.\tO\n075mg\tO\n/\tO\nkg\tO\ndose\tO\nof\tO\nFazadinium\tB-Chemical\n)\tO\ndid\tO\nnot\tO\ninfluence\tO\nthe\tO\noccurrence\tO\nof\tO\nscoline\tB-Chemical\npain\tB-Disease\n.\tO\n\nNeither\tO\nthe\tO\ntype\tO\nof\tO\ninduction\tO\nagent\tO\n(\tO\nAlthesin\tB-Chemical\nor\tO\nThiopentone\tB-Chemical\n)\tO\nnor\tO\nthe\tO\nsalt\tO\npreparation\tO\nof\tO\nsuxamethonium\tB-Chemical\nused\tO\n(\tO\nchloride\tB-Chemical\nor\tO\nbromide\tB-Chemical\n)\tO\n,\tO\naffected\tO\nthe\tO\nincidence\tO\nof\tO\nscoline\tB-Chemical\npain\tB-Disease\n.\tO\n\nInvasive\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nrenal\tI-Disease\npelvis\tI-Disease\nfollowing\tO\ncyclophosphamide\tB-Chemical\ntherapy\tO\nfor\tO\nnonmalignant\tO\ndisease\tO\n.\tO\n\nA\tO\n47\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nright\tO\nhydroureteronephrosis\tB-Disease\ndue\tO\nto\tO\nureterovesical\tO\njunction\tO\nobstruction\tO\nhad\tO\ngross\tO\nhematuria\tB-Disease\nafter\tO\nbeing\tO\ntreated\tO\nfor\tO\nfive\tO\nyears\tO\nwtih\tO\ncyclophosphamide\tB-Chemical\nfor\tO\ncerebral\tB-Disease\nvasculitis\tI-Disease\n.\tO\n\nA\tO\nright\tO\nnephroureterectomy\tO\nwas\tO\nrequired\tO\nfor\tO\ncontrol\tO\nof\tO\nbleeding\tB-Disease\n.\tO\n\nThe\tO\npathology\tO\nspecimen\tO\ncontained\tO\nclinically\tO\noccult\tO\ninvasive\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nrenal\tI-Disease\npelvis\tI-Disease\n.\tO\n\nAlthough\tO\nthe\tO\nability\tO\nof\tO\ncyclophosphamide\tB-Chemical\nto\tO\ncause\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\nand\tO\nurine\tO\ncytologic\tO\nabnormalities\tO\nindistinguishable\tO\nfrom\tO\nhigh\tO\ngrade\tO\ncarcinoma\tB-Disease\nis\tO\nwell\tO\nknown\tO\n,\tO\nit\tO\nis\tO\nless\tO\nwidely\tO\nappreciated\tO\nthat\tO\nit\tO\nis\tO\nalso\tO\nassociated\tO\nwith\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nurinary\tI-Disease\ntract\tI-Disease\n.\tO\n\nTwenty\tO\ncarcinomas\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nurinary\tI-Disease\nbladder\tI-Disease\nand\tO\none\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nprostate\tI-Disease\nhave\tO\nbeen\tO\nreported\tO\nin\tO\nassociation\tO\nwith\tO\nits\tO\nuse\tO\n.\tO\n\nThe\tO\npresent\tO\ncase\tO\nis\tO\nthe\tO\nfirst\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nrenal\tI-Disease\npelvis\tI-Disease\nreported\tO\nin\tO\nassociation\tO\nwith\tO\ncyclophosphamide\tB-Chemical\ntreatment\tO\n.\tO\n\nIt\tO\nis\tO\nthe\tO\nthird\tO\nurinary\tB-Disease\ntract\tI-Disease\ncancer\tI-Disease\nreported\tO\nin\tO\nassociation\tO\nwith\tO\ncyclophosphamide\tB-Chemical\ntreatment\tO\nfor\tO\nnonmalignant\tO\ndisease\tO\n.\tO\n\nThe\tO\nassociation\tO\nof\tO\nthe\tO\ntumor\tB-Disease\nwith\tO\npreexisting\tO\nhydroureteronephrosis\tB-Disease\nsuggests\tO\nthat\tO\nstasis\tO\nprolonged\tO\nand\tO\nintensified\tO\nexposure\tO\nof\tO\nupper\tO\nurinary\tO\ntract\tO\nepithelium\tO\nto\tO\ncyclophosphamide\tB-Chemical\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\ncandidates\tO\nfor\tO\nlong\tO\n-\tO\nterm\tO\ncyclophosphamide\tB-Chemical\ntreatment\tO\nshould\tO\nbe\tO\nroutinely\tO\nevaluated\tO\nfor\tO\nobstructive\tB-Disease\nuropathy\tI-Disease\n.\tO\n\nMedial\tO\nchanges\tO\nin\tO\narterial\tO\nspasm\tB-Disease\ninduced\tO\nby\tO\nL\tB-Chemical\n-\tI-Chemical\nnorepinephrine\tI-Chemical\n.\tO\n\nIn\tO\nnormal\tO\nrats\tO\n,\tO\nthe\tO\nmedia\tO\nof\tO\nsmall\tO\narteries\tO\n(\tO\n0\tO\n.\tO\n4\tO\n-\tO\n-\tO\n0\tO\n.\tO\n2\tO\nmm\tO\nin\tO\ndiameter\tO\n)\tO\npreviously\tO\nwas\tO\nshown\tO\nto\tO\ncontain\tO\nintracellular\tO\nvacuoles\tO\n,\tO\nidentified\tO\nultrastructurally\tO\nas\tO\nherniations\tO\nof\tO\none\tO\nsmooth\tO\nmuscle\tO\ncell\tO\ninto\tO\nanother\tO\n.\tO\n\nThe\tO\nhypothesis\tO\nthat\tO\nintense\tO\nvasoconstriction\tO\nwould\tO\nincrease\tO\nthe\tO\nnumber\tO\nof\tO\nsuch\tO\nvacuoles\tO\nhas\tO\nbeen\tO\ntested\tO\n.\tO\n\nIn\tO\nthe\tO\nmedia\tO\nof\tO\nthe\tO\nsaphenous\tO\nartery\tO\nand\tO\nits\tO\ndistal\tO\nbranch\tO\n,\tO\nvasoconstriction\tO\ninduced\tO\nby\tO\nL\tB-Chemical\n-\tI-Chemical\nnorepinephrine\tI-Chemical\nproduced\tO\nmany\tO\ncell\tO\n-\tO\nto\tO\n-\tO\ncell\tO\nhernias\tB-Disease\nwithin\tO\n15\tO\nminutes\tO\n.\tO\n\nAt\tO\n1\tO\nday\tO\ntheir\tO\nnumber\tO\nwas\tO\nreduced\tO\nto\tO\nabout\tO\n1\tO\n/\tO\n10\tO\nof\tO\nthe\tO\noriginal\tO\nnumber\tO\n.\tO\n\nBy\tO\n7\tO\ndays\tO\nthe\tO\nvessel\tO\nwas\tO\nalmost\tO\nrestored\tO\nto\tO\nnormal\tO\n.\tO\n\nTriple\tO\nstimulation\tO\nover\tO\n1\tO\nday\tO\ninduced\tO\nmore\tO\nsevere\tO\nchanges\tO\nin\tO\nthe\tO\nmedia\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nsmooth\tO\nmuscle\tO\ncells\tO\nare\tO\nsusceptible\tO\nto\tO\ndamage\tO\nin\tO\nthe\tO\ncourse\tO\nof\tO\ntheir\tO\nspecific\tO\nfunction\tO\n.\tO\n\nThe\tO\nexperimental\tO\ndata\tO\nare\tO\ndiscussed\tO\nin\tO\nrelation\tO\nto\tO\nmedial\tO\nchanges\tO\nobserved\tO\nin\tO\nother\tO\ninstances\tO\nof\tO\narterial\tO\nspasm\tB-Disease\n.\tO\n\nEndothelial\tO\nchanges\tO\nthat\tO\ndeveloped\tO\nin\tO\nthe\tO\nsame\tO\nexperimental\tO\nmodel\tO\nwere\tO\ndescribed\tO\nin\tO\na\tO\nprevious\tO\npaper\tO\n.\tO\n\nBilateral\tO\nretinal\tB-Disease\nartery\tI-Disease\nand\tI-Disease\nchoriocapillaris\tI-Disease\nocclusion\tI-Disease\nfollowing\tO\nthe\tO\ninjection\tO\nof\tO\nlong\tO\n-\tO\nacting\tO\ncorticosteroid\tB-Chemical\nsuspensions\tO\nin\tO\ncombination\tO\nwith\tO\nother\tO\ndrugs\tO\n:\tO\nI\tO\n.\tO\n\nClinical\tO\nstudies\tO\n.\tO\n\nTwo\tO\nwell\tO\n-\tO\ndocumented\tO\ncases\tO\nof\tO\nbilateral\tO\nretinal\tB-Disease\nartery\tI-Disease\nand\tI-Disease\nchoriocapillaris\tI-Disease\nocclusions\tI-Disease\nwith\tO\nblindness\tB-Disease\nfollowing\tO\nhead\tO\nand\tO\nneck\tO\nsoft\tO\n-\tO\ntissue\tO\ninjection\tO\nwith\tO\nmethylprednisolone\tB-Chemical\nacetate\tI-Chemical\nin\tO\ncombination\tO\nwith\tO\nlidocaine\tB-Chemical\n,\tO\nepinephrine\tB-Chemical\n,\tO\nor\tO\npenicillin\tB-Chemical\nare\tO\nreported\tO\n.\tO\n\nOne\tO\ncase\tO\nhad\tO\nonly\tO\na\tO\nunilateral\tO\ninjection\tO\n.\tO\n\nThe\tO\nacute\tO\nobservations\tO\nincluded\tO\nhazy\tO\nsensorium\tO\n,\tO\nsuperior\tO\ngaze\tO\npalsy\tB-Disease\n,\tO\npupillary\tB-Disease\nabnormalities\tI-Disease\n,\tO\nand\tO\nconjunctival\tO\nhemorrhages\tB-Disease\nwith\tO\nedema\tB-Disease\n.\tO\n\nFollow\tO\n-\tO\nup\tO\nchanges\tO\nshowed\tO\nmarked\tO\nvisual\tB-Disease\nloss\tI-Disease\n,\tO\nconstricted\tO\nvisual\tO\nfields\tO\n,\tO\noptic\tO\nnerve\tO\npallor\tO\n,\tO\nvascular\tO\nattenuation\tO\n,\tO\nand\tO\nchorioretinal\tB-Disease\natrophy\tI-Disease\n.\tO\n\nThe\tO\nliterature\tO\nis\tO\nreviewed\tO\n,\tO\nand\tO\npossible\tO\ncauses\tO\nare\tO\ndiscussed\tO\n.\tO\n\nAbnormalities\tO\nof\tO\nthe\tO\npupil\tO\nand\tO\nvisual\tO\n-\tO\nevoked\tO\npotential\tO\nin\tO\nquinine\tB-Chemical\namblyopia\tB-Disease\n.\tO\n\nTotal\tO\nblindness\tB-Disease\nwith\tO\na\tO\ntransient\tO\ntonic\tB-Disease\npupillary\tI-Disease\nresponse\tO\n,\tO\ndenervation\tO\nsupersensitivity\tO\n,\tO\nand\tO\nabnormal\tO\nvisual\tO\n-\tO\nevoked\tO\npotentials\tO\ndeveloped\tO\nin\tO\na\tO\n54\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nafter\tO\nthe\tO\nuse\tO\nof\tO\nquinine\tB-Chemical\nsulfate\tI-Chemical\nfor\tO\nleg\tB-Disease\ncramps\tI-Disease\n.\tO\n\nHe\tO\nlater\tO\nrecovered\tO\nnormal\tO\nvisual\tO\nacuity\tO\n.\tO\n\nA\tO\ntransient\tO\ntonic\tB-Disease\npupillary\tI-Disease\nresponse\tO\n,\tO\ndenervation\tO\nsupersensitivity\tO\n,\tO\nand\tO\nabnormal\tO\nvisual\tO\n-\tO\nevoked\tO\npotentials\tO\nin\tO\nquinine\tB-Chemical\ntoxicity\tB-Disease\n,\tO\nto\tO\nour\tO\nknowledge\tO\n,\tO\nhave\tO\nnot\tO\nbeen\tO\npreviously\tO\nreported\tO\n.\tO\n\nSuxamethonium\tB-Chemical\n-\tO\ninduced\tO\njaw\tB-Disease\nstiffness\tI-Disease\nand\tO\nmyalgia\tB-Disease\nassociated\tO\nwith\tO\natypical\tO\ncholinesterase\tO\n:\tO\ncase\tO\nreport\tO\n.\tO\n\nAn\tO\n11\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwas\tO\ngiven\tO\nhalothane\tB-Chemical\n,\tO\nnitrous\tB-Chemical\noxide\tI-Chemical\nand\tO\noxygen\tB-Chemical\n,\tO\npancuronium\tB-Chemical\n0\tO\n.\tO\n4\tO\nmg\tO\nand\tO\nsuxamethonium\tB-Chemical\n100\tO\nmg\tO\nfor\tO\ninduction\tO\nof\tO\nanaesthesia\tO\n.\tO\n\nIn\tO\nresponse\tO\nto\tO\nthis\tO\na\tO\nmarked\tO\njaw\tB-Disease\nstiffness\tI-Disease\noccurred\tO\nwhich\tO\nlasted\tO\nfor\tO\ntwo\tO\nminutes\tO\nand\tO\nthe\tO\nanaesthesia\tO\nwere\tO\nterminated\tO\n.\tO\n\nFour\tO\nhours\tO\nof\tO\napnoea\tB-Disease\nensued\tO\nand\tO\nhe\tO\nsuffered\tO\ngeneralized\tO\nsevere\tO\nmyalgia\tB-Disease\nlasting\tO\nfor\tO\none\tO\nweek\tO\n.\tO\n\nHe\tO\nwas\tO\nfound\tO\nto\tO\nhave\tO\natypical\tO\nplasma\tO\ncholinesterase\tO\nwith\tO\na\tO\ndibucaine\tB-Chemical\nnumber\tO\nof\tO\n12\tO\n,\tO\nindicating\tO\nhomozygocity\tO\n.\tO\n\nThis\tO\nwas\tO\nverified\tO\nby\tO\nstudy\tO\nof\tO\nthe\tO\nfamily\tO\n.\tO\n\nThe\tO\ncase\tO\nshows\tO\nthat\tO\nprolonged\tB-Disease\njaw\tI-Disease\nrigidity\tI-Disease\nand\tO\nmyalgia\tB-Disease\nmay\tO\noccur\tO\nafter\tO\nsuxamethonium\tB-Chemical\nin\tO\npatients\tO\nwith\tO\natypical\tO\ncholinesterase\tO\ndespite\tO\npretreatment\tO\nwith\tO\npancuronium\tB-Chemical\n.\tO\n\nIndomethacin\tB-Chemical\n-\tO\ninduced\tO\nhyperkalemia\tB-Disease\nin\tO\nthree\tO\npatients\tO\nwith\tO\ngouty\tB-Disease\narthritis\tI-Disease\n.\tO\n\nWe\tO\ndescribe\tO\nthree\tO\npatients\tO\nin\tO\nwhom\tO\nsevere\tO\n,\tO\nlife\tO\n-\tO\nthreatening\tO\nhyperkalemia\tB-Disease\nand\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\ndeveloped\tO\nafter\tO\ntreatment\tO\nof\tO\nacute\tO\ngouty\tB-Disease\narthritis\tI-Disease\nwith\tO\nindomethacin\tB-Chemical\n.\tO\n\nThis\tO\ncomplication\tO\nmay\tO\nresult\tO\nfrom\tO\nan\tO\ninhibition\tO\nof\tO\nprostaglandin\tB-Chemical\nsynthesis\tO\nand\tO\nconsequent\tO\nhyporeninemic\tB-Disease\nhypoaidosteronism\tI-Disease\n.\tO\n\nCareful\tO\nattention\tO\nto\tO\nrenal\tO\nfunction\tO\nand\tO\npotassium\tB-Chemical\nbalance\tO\nin\tO\npatients\tO\nreceiving\tO\nindomethacin\tB-Chemical\nor\tO\nother\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\nagents\tO\n,\tO\nparticularly\tO\nin\tO\nthose\tO\npatients\tO\nwith\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\nor\tO\npreexisting\tO\nrenal\tB-Disease\ndisease\tI-Disease\n,\tO\nwill\tO\nhelp\tO\nprevent\tO\nthis\tO\npotentially\tO\nserious\tO\ncomplication\tO\n.\tO\n\nEtomidate\tB-Chemical\n:\tO\na\tO\nforeshortened\tO\nclinical\tO\ntrial\tO\n.\tO\n\nA\tO\nclinical\tO\nevaluation\tO\nof\tO\netomidate\tB-Chemical\nfor\tO\noutpatient\tO\ncystoscopy\tO\nwas\tO\nembarked\tO\nupon\tO\n.\tO\n\nUnpremedicated\tO\npatients\tO\nwere\tO\ngiven\tO\nfentanyl\tB-Chemical\n1\tO\nmicrogram\tO\n/\tO\nkg\tO\nfollowed\tO\nby\tO\netomidate\tB-Chemical\n0\tO\n.\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nAnaesthesia\tO\nwas\tO\nmaintained\tO\nwith\tO\nintermittent\tO\netomidate\tB-Chemical\nin\tO\n2\tO\n-\tO\n4\tO\nmg\tO\ndoses\tO\n.\tO\n\nPatients\tO\nwere\tO\ninterviewed\tO\npersonally\tO\nlater\tO\nthe\tO\nsame\tO\nday\tO\n,\tO\nand\tO\nby\tO\nquestionnaire\tO\nthree\tO\nto\tO\nfour\tO\nweeks\tO\nlater\tO\n.\tO\n\nThe\tO\ntrial\tO\nwas\tO\ndiscontinued\tO\nafter\tO\n20\tO\ncases\tO\nbecause\tO\nof\tO\nan\tO\nunacceptable\tO\nincidence\tO\nof\tO\nside\tO\neffects\tO\n.\tO\n\nVenous\tO\npain\tB-Disease\noccurred\tO\nin\tO\n68\tO\n%\tO\nof\tO\npatients\tO\nand\tO\n50\tO\n%\tO\nhad\tO\nredness\tO\n,\tO\npain\tB-Disease\nor\tO\nswelling\tB-Disease\nrelated\tO\nto\tO\nthe\tO\ninjection\tO\nsite\tO\n,\tO\nin\tO\nsome\tO\ncases\tO\nlasting\tO\nup\tO\nto\tO\nthree\tO\nweeks\tO\nafter\tO\nanaesthesia\tO\n.\tO\n\nSkeletal\tO\nmovements\tO\noccurred\tO\nin\tO\n50\tO\n%\tO\nof\tO\npatients\tO\n;\tO\n30\tO\n%\tO\nexperienced\tO\nrespiratory\tB-Disease\nupset\tI-Disease\n,\tO\none\tO\nsufficiently\tO\nsevere\tO\nto\tO\nnecessitate\tO\nabandoning\tO\nthe\tO\ntechnique\tO\n.\tO\n\nNausea\tB-Disease\nand\tO\nvomiting\tB-Disease\noccurred\tO\nin\tO\n40\tO\n%\tO\nand\tO\n25\tO\n%\tO\nhad\tO\ndisturbing\tO\nemergence\tO\npsychoses\tB-Disease\n.\tO\n\nLevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nare\tO\nimproved\tO\nby\tO\nfluoxetine\tB-Chemical\n.\tO\n\nWe\tO\nevaluated\tO\nthe\tO\nseverity\tO\nof\tO\nmotor\tB-Disease\ndisability\tI-Disease\nand\tO\ndyskinesias\tB-Disease\nin\tO\nseven\tO\nlevodopa\tB-Chemical\n-\tO\nresponsive\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nafter\tO\nan\tO\nacute\tO\nchallenge\tO\nwith\tO\nthe\tO\nmixed\tO\ndopamine\tB-Chemical\nagonist\tO\n,\tO\napomorphine\tB-Chemical\n,\tO\nbefore\tO\nand\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\nfluoxetine\tB-Chemical\n(\tO\n20\tO\nmg\tO\ntwice\tO\nper\tO\nday\tO\n)\tO\nfor\tO\n11\tO\n+\tO\n/\tO\n-\tO\n1\tO\ndays\tO\n.\tO\n\nAfter\tO\nfluoxetine\tB-Chemical\ntreatment\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nsignificant\tO\n47\tO\n%\tO\nimprovement\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nwithout\tO\nmodification\tO\nof\tO\nparkinsonian\tB-Disease\nmotor\tB-Disease\ndisability\tI-Disease\n.\tO\n\nThe\tO\ndyskinesias\tB-Disease\nwere\tO\nreduced\tO\npredominantly\tO\nin\tO\nthe\tO\nlower\tO\nlimbs\tO\nduring\tO\nthe\tO\nonset\tO\nand\tO\ndisappearance\tO\nof\tO\ndystonic\tB-Disease\ndyskinesias\tI-Disease\n(\tO\nonset\tO\n-\tO\nand\tO\nend\tO\n-\tO\nof\tO\n-\tO\ndose\tO\ndyskinesias\tB-Disease\n)\tO\nand\tO\nin\tO\nthe\tO\nupper\tO\nlimbs\tO\nduring\tO\nchoreic\tB-Disease\nmid\tI-Disease\n-\tI-Disease\ndose\tI-Disease\ndyskinesias\tI-Disease\n.\tO\n\nThe\tO\nresults\tO\nsuggest\tO\nthat\tO\nincreased\tO\nbrain\tO\nserotoninergic\tO\ntransmission\tO\nwith\tO\nfluoxetine\tB-Chemical\nmay\tO\nreduce\tO\nlevodopa\tB-Chemical\n-\tO\nor\tO\ndopamine\tB-Chemical\nagonist\tO\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nwithout\tO\naggravating\tO\nparkinsonian\tB-Disease\nmotor\tB-Disease\ndisability\tI-Disease\n.\tO\n\nA\tO\nlarge\tO\npopulation\tO\n-\tO\nbased\tO\nfollow\tO\n-\tO\nup\tO\nstudy\tO\nof\tO\ntrimethoprim\tB-Chemical\n-\tI-Chemical\nsulfamethoxazole\tI-Chemical\n,\tO\ntrimethoprim\tB-Chemical\n,\tO\nand\tO\ncephalexin\tB-Chemical\nfor\tO\nuncommon\tO\nserious\tO\ndrug\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nWe\tO\nconducted\tO\na\tO\npopulation\tO\n-\tO\nbased\tO\n45\tO\n-\tO\nday\tO\nfollow\tO\n-\tO\nup\tO\nstudy\tO\nof\tO\n232\tO\n,\tO\n390\tO\npeople\tO\nwho\tO\nwere\tO\nprescribed\tO\ntrimethoprim\tB-Chemical\n-\tI-Chemical\nsulfamethoxazole\tI-Chemical\n(\tO\nTMP\tB-Chemical\n-\tI-Chemical\nSMZ\tI-Chemical\n)\tO\n,\tO\n266\tO\n,\tO\n951\tO\nprescribed\tO\ntrimethoprim\tB-Chemical\nalone\tO\n,\tO\nand\tO\n196\tO\n,\tO\n397\tO\nprescribed\tO\ncephalexin\tB-Chemical\n,\tO\nto\tO\nestimate\tO\nthe\tO\nrisk\tO\nof\tO\nserious\tO\nliver\tB-Disease\n,\tI-Disease\nblood\tI-Disease\n,\tI-Disease\nskin\tI-Disease\n,\tI-Disease\nand\tI-Disease\nrenal\tI-Disease\ndisorders\tI-Disease\nresulting\tO\nin\tO\nreferral\tO\nor\tO\nhospitalization\tO\nassociated\tO\nwith\tO\nthese\tO\ndrugs\tO\n.\tO\n\nThe\tO\nresults\tO\nwere\tO\nbased\tO\non\tO\ninformation\tO\nrecorded\tO\non\tO\noffice\tO\ncomputers\tO\nby\tO\nselected\tO\ngeneral\tO\npractitioners\tO\nin\tO\nthe\tO\nUnited\tO\nKingdom\tO\n,\tO\ntogether\tO\nwith\tO\na\tO\nreview\tO\nof\tO\nclinical\tO\nrecords\tO\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nclinically\tO\nimportant\tO\nidiopathic\tO\nliver\tB-Disease\ndisease\tI-Disease\nwas\tO\nsimilar\tO\nfor\tO\npersons\tO\nprescribed\tO\nTMP\tB-Chemical\n-\tI-Chemical\nSMZ\tI-Chemical\n(\tO\n5\tO\n.\tO\n2\tO\n/\tO\n100\tO\n,\tO\n000\tO\n)\tO\nand\tO\nthose\tO\nprescribed\tO\ntrimethoprim\tB-Chemical\nalone\tO\n(\tO\n3\tO\n.\tO\n8\tO\n/\tO\n100\tO\n,\tO\n000\tO\n)\tO\n.\tO\n\nThe\tO\nrisk\tO\nfor\tO\nthose\tO\nprescribed\tO\ncephalexin\tB-Chemical\nwas\tO\nsomewhat\tO\nlower\tO\n(\tO\n2\tO\n.\tO\n0\tO\n/\tO\n100\tO\n,\tO\n000\tO\n)\tO\n.\tO\n\nOnly\tO\nfive\tO\npatients\tO\nexperienced\tO\nblood\tO\ndisorders\tO\n,\tO\none\tO\nof\tO\nwhom\tO\nwas\tO\nexposed\tO\nto\tO\nTMP\tB-Chemical\n-\tI-Chemical\nSMZ\tI-Chemical\n;\tO\nof\tO\nseven\tO\nwith\tO\nerythema\tB-Disease\nmultiforme\tI-Disease\nand\tO\nStevens\tB-Disease\n-\tI-Disease\nJohnson\tI-Disease\nsyndrome\tI-Disease\n,\tO\nfour\tO\nwere\tO\nexposed\tO\nto\tO\nTMP\tB-Chemical\n-\tI-Chemical\nSMZ\tI-Chemical\n.\tO\n\nThe\tO\none\tO\ncase\tO\nof\tO\ntoxic\tB-Disease\nepidermal\tI-Disease\nnecrolysis\tI-Disease\noccurred\tO\nin\tO\na\tO\npatient\tO\nwho\tO\ntook\tO\ncephalexin\tB-Chemical\n.\tO\n\nFinally\tO\n,\tO\nonly\tO\nfive\tO\ncases\tO\nof\tO\nacute\tO\nparenchymal\tO\nrenal\tB-Disease\ndisease\tI-Disease\noccurred\tO\n,\tO\nnone\tO\nlikely\tO\nto\tO\nbe\tO\ncaused\tO\nby\tO\na\tO\nstudy\tO\ndrug\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nthe\tO\nrisk\tO\nof\tO\nthe\tO\nserious\tO\ndiseases\tO\nstudied\tO\nis\tO\nsmall\tO\nfor\tO\nthe\tO\nthree\tO\nagents\tO\n,\tO\nand\tO\ncompares\tO\nreasonably\tO\nwith\tO\nthe\tO\nrisk\tO\nfor\tO\nmany\tO\nother\tO\nantibiotics\tO\n.\tO\n\nClinical\tO\nsafety\tO\nof\tO\nlidocaine\tB-Chemical\nin\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nsafety\tO\nof\tO\nlidocaine\tB-Chemical\nin\tO\nthe\tO\nsetting\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n(\tO\nMI\tB-Disease\n)\tO\n.\tO\n\nDESIGN\tO\n:\tO\nA\tO\nretrospective\tO\n,\tO\nmulticenter\tO\nstudy\tO\n.\tO\n\nSETTING\tO\n:\tO\nTwenty\tO\n-\tO\nnine\tO\nuniversity\tO\n,\tO\nuniversity\tO\n-\tO\naffiliated\tO\n,\tO\nor\tO\ncommunity\tO\nhospitals\tO\nduring\tO\na\tO\n6\tO\n-\tO\nyear\tO\nperiod\tO\n(\tO\ntotal\tO\nof\tO\n117\tO\ncumulative\tO\nhospital\tO\n-\tO\nyears\tO\n)\tO\n.\tO\n\nPARTICIPANTS\tO\n:\tO\nPatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nMI\tB-Disease\nwho\tO\nreceived\tO\nlidocaine\tB-Chemical\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOf\tO\n29\tO\npatients\tO\nwho\tO\nreceived\tO\nlidocaine\tB-Chemical\nin\tO\nthe\tO\nsetting\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nMI\tB-Disease\n,\tO\nno\tO\npatient\tO\ndied\tO\n;\tO\nexhibited\tO\nbradydysrhythmias\tB-Disease\n,\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n,\tO\nor\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\n;\tO\nor\tO\nexperienced\tO\nseizures\tB-Disease\nafter\tO\nadministration\tO\nof\tO\nlidocaine\tB-Chemical\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n%\tO\nto\tO\n11\tO\n%\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nDespite\tO\ntheoretical\tO\nconcerns\tO\nthat\tO\nlidocaine\tB-Chemical\nmay\tO\nenhance\tO\ncocaine\tB-Chemical\ntoxicity\tB-Disease\n,\tO\nthe\tO\nuse\tO\nof\tO\nlidocaine\tB-Chemical\nin\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nMI\tB-Disease\nwas\tO\nnot\tO\nassociated\tO\nwith\tO\nsignificant\tO\ncardiovascular\tB-Disease\nor\tI-Disease\ncentral\tI-Disease\nnervous\tI-Disease\nsystem\tI-Disease\ntoxicity\tI-Disease\n.\tO\n\nExperimental\tO\nprogressive\tO\nmuscular\tB-Disease\ndystrophy\tI-Disease\nand\tO\nits\tO\ntreatment\tO\nwith\tO\nhigh\tO\ndoses\tO\nanabolizing\tO\nagents\tO\n.\tO\n\nWe\tO\nare\tO\nstill\tO\na\tO\nlong\tO\nway\tO\nfrom\tO\ndiscovering\tO\nan\tO\nunequivocal\tO\npathogenetic\tO\ninterpretation\tO\nof\tO\nprogressive\tO\nmuscular\tB-Disease\ndystrophy\tI-Disease\nin\tO\nman\tO\n.\tO\n\nNoteworthy\tO\nefforts\tO\nhave\tO\nbeen\tO\nmade\tO\nin\tO\nthe\tO\nexperimental\tO\nfield\tO\n;\tO\na\tO\nrecessive\tO\nautosomic\tO\nform\tO\nfound\tO\nin\tO\nthe\tO\nmouse\tO\nseems\tO\nto\tO\nbear\tO\nthe\tO\nclosest\tO\nresemblance\tO\nto\tO\nthe\tO\nhuman\tO\nform\tO\nfrom\tO\nthe\tO\ngenetic\tO\npoint\tO\nof\tO\nview\tO\n.\tO\n\nMyopathy\tB-Disease\ndue\tO\nto\tO\nlack\tO\nof\tO\nvitamin\tB-Chemical\nE\tI-Chemical\nand\tO\nmyopathy\tB-Disease\ninduced\tO\nby\tO\ncertain\tO\nviruses\tO\nhave\tO\nmuch\tO\nin\tO\ncommon\tO\nanatomically\tO\nand\tO\npathologically\tO\nwith\tO\nthe\tO\nhuman\tO\nform\tO\n.\tO\n\nThe\tO\nauthors\tO\ninduced\tO\nmyodystrophy\tB-Disease\nin\tO\nthe\tO\nrat\tO\nby\tO\ngiving\tO\nit\tO\na\tO\ndiet\tO\nlacking\tO\nin\tO\nvitamin\tB-Chemical\nE\tI-Chemical\n.\tO\n\nThe\tO\npharmacological\tO\ncharacteristics\tO\nof\tO\nvitamin\tB-Chemical\nE\tI-Chemical\nand\tO\nthe\tO\ndegenerative\tO\nchanges\tO\nbrought\tO\nabout\tO\nby\tO\nits\tO\ndeficiency\tO\n,\tO\nespecially\tO\nin\tO\nthe\tO\nmuscles\tO\n,\tO\nare\tO\nillustrated\tO\n.\tO\n\nIt\tO\nis\tO\nthus\tO\nconfirmed\tO\nthat\tO\nthe\tO\nhistological\tO\ncharacteristics\tO\nof\tO\nmyopathic\tB-Disease\nrat\tO\nmuscle\tO\ninduced\tO\nexperimentally\tO\nare\tO\nextraordinarily\tO\nsimilar\tO\nto\tO\nthose\tO\nof\tO\nhuman\tO\nmyopathy\tB-Disease\nas\tO\nconfirmed\tO\nduring\tO\nbiopsies\tO\nperformed\tO\nat\tO\nthe\tO\nOrthopaedic\tO\nTraumatological\tO\nCentre\tO\n,\tO\nFlorence\tO\n.\tO\n\nThe\tO\nencouraging\tO\nresults\tO\nobtained\tO\nin\tO\nvarious\tO\nauthoratative\tO\ndepartments\tO\nin\tO\nmyopathic\tB-Disease\npatients\tO\nby\tO\nusing\tO\nanabolizing\tO\nsteroids\tB-Chemical\nhave\tO\nencouraged\tO\nthe\tO\nauthors\tO\nto\tO\ninvestigate\tO\nthe\tO\nbeneficial\tO\neffects\tO\nof\tO\none\tO\nanabolizing\tO\nagent\tO\n(\tO\nDianabol\tB-Chemical\n,\tO\nCIBA\tB-Chemical\n)\tO\nat\tO\nhigh\tO\ndoses\tO\nin\tO\nrats\tO\nrendered\tO\nmyopathic\tB-Disease\nby\tO\na\tO\ndiet\tO\ndeficient\tO\nin\tO\nvitamin\tB-Chemical\nE\tI-Chemical\n.\tO\n\nIn\tO\nthis\tO\nway\tO\nthey\tO\nobtained\tO\nappreciable\tO\nchanges\tO\nin\tO\nbody\tO\nweight\tO\n(\tO\nincreased\tO\nfrom\tO\n50\tO\nto\tO\n70\tO\ng\tO\nafter\tO\nforty\tO\ndays\tO\nat\tO\na\tO\ndose\tO\nof\tO\n5\tO\nmg\tO\nper\tO\nday\tO\nof\tO\nanabolizing\tO\nagent\tO\n)\tO\n,\tO\nbut\tO\nmost\tO\nof\tO\nall\tO\nthey\tO\nfound\tO\nhistological\tO\nchanges\tO\ndue\tO\nto\tO\n\"\tO\nregenerative\tO\n\"\tO\nchanges\tO\nin\tO\nthe\tO\nmuscle\tO\ntissue\tO\n,\tO\nwhich\tO\nhowever\tO\nmaintained\tO\nits\tO\nmyopathic\tB-Disease\ncharacteristics\tO\nin\tO\nthe\tO\ncontrol\tO\nanimals\tO\nthat\tO\nwere\tO\nnot\tO\ntreated\tO\nwith\tO\nthe\tO\nanabolizing\tO\nagent\tO\n.\tO\n\nThe\tO\nauthors\tO\nconclude\tO\nby\tO\naffirming\tO\nthe\tO\nundoubted\tO\nefficacy\tO\nof\tO\nthe\tO\nanabolizing\tO\nsteroids\tB-Chemical\nin\tO\nexperimental\tO\nmyopathic\tB-Disease\ndisease\tI-Disease\n,\tO\nbut\tO\nthey\tO\nhave\tO\nreservations\tO\nas\tO\nto\tO\nthe\tO\ntransfer\tO\nof\tO\nthe\tO\nresults\tO\ninto\tO\nthe\tO\nhuman\tO\nfield\tO\n,\tO\nwhere\tO\nhigh\tO\ndosage\tO\ncannot\tO\nbe\tO\ncarried\tO\nout\tO\ncontinuously\tO\nbecause\tO\nof\tO\nthe\tO\neffects\tO\nof\tO\nthe\tO\ndrug\tO\non\tO\nvirility\tO\n;\tO\nbecause\tO\nthe\tO\ntissue\tO\ninjury\tO\ntoo\tO\noften\tO\noccurs\tO\nat\tO\nan\tO\nirreversible\tO\nstage\tO\nvis\tO\n-\tO\na\tO\n-\tO\nvis\tO\nthe\tO\n\"\tO\nregeneration\tO\n\"\tO\nof\tO\nthe\tO\nmuscle\tO\ntissue\tO\n;\tO\nand\tO\nfinally\tO\nbecause\tO\nthe\tO\ndystrophic\tO\ninjurious\tO\nagent\tO\nis\tO\ncertainly\tO\nnot\tO\nthe\tO\nlack\tO\nof\tO\nvitamin\tB-Chemical\nE\tI-Chemical\nbut\tO\nsomething\tO\nas\tO\nyet\tO\nunknown\tO\n.\tO\n\nPaclitaxel\tB-Chemical\n3\tO\n-\tO\nhour\tO\ninfusion\tO\ngiven\tO\nalone\tO\nand\tO\ncombined\tO\nwith\tO\ncarboplatin\tB-Chemical\n:\tO\npreliminary\tO\nresults\tO\nof\tO\ndose\tO\n-\tO\nescalation\tO\ntrials\tO\n.\tO\n\nPaclitaxel\tB-Chemical\n(\tO\nTaxol\tB-Chemical\n;\tO\nBristol\tO\n-\tO\nMyers\tO\nSquibb\tO\nCompany\tO\n,\tO\nPrinceton\tO\n,\tO\nNJ\tO\n)\tO\nby\tO\n3\tO\n-\tO\nhour\tO\ninfusion\tO\nwas\tO\ncombined\tO\nwith\tO\ncarboplatin\tB-Chemical\nin\tO\na\tO\nphase\tO\nI\tO\n/\tO\nII\tO\nstudy\tO\ndirected\tO\nto\tO\npatients\tO\nwith\tO\nnon\tB-Disease\n-\tI-Disease\nsmall\tI-Disease\ncell\tI-Disease\nlung\tI-Disease\ncancer\tI-Disease\n.\tO\n\nCarboplatin\tB-Chemical\nwas\tO\ngiven\tO\nat\tO\na\tO\nfixed\tO\ntarget\tO\narea\tO\nunder\tO\nthe\tO\nconcentration\tO\n-\tO\ntime\tO\ncurve\tO\nof\tO\n6\tO\n.\tO\n0\tO\nby\tO\nthe\tO\nCalvert\tO\nformula\tO\n,\tO\nwhereas\tO\npaclitaxel\tB-Chemical\nwas\tO\nescalated\tO\nin\tO\npatient\tO\ncohorts\tO\nfrom\tO\n150\tO\nmg\tO\n/\tO\nm2\tO\n(\tO\ndose\tO\nlevel\tO\nI\tO\n)\tO\nto\tO\n175\tO\n,\tO\n200\tO\n,\tO\n225\tO\n,\tO\nand\tO\n250\tO\nmg\tO\n/\tO\nm2\tO\n.\tO\n\nThe\tO\n225\tO\nmg\tO\n/\tO\nm2\tO\nlevel\tO\nwas\tO\nexpanded\tO\nfor\tO\nthe\tO\nphase\tO\nII\tO\nstudy\tO\nsince\tO\nthe\tO\nhighest\tO\nlevel\tO\nachieved\tO\n(\tO\n250\tO\nmg\tO\n/\tO\nm2\tO\n)\tO\nrequired\tO\nmodification\tO\nbecause\tO\nof\tO\nnonhematologic\tO\ntoxicities\tB-Disease\n(\tO\narthralgia\tB-Disease\nand\tO\nsensory\tB-Disease\nneuropathy\tI-Disease\n)\tO\n.\tO\n\nTherapeutic\tO\neffects\tO\nwere\tO\nnoted\tO\nat\tO\nall\tO\ndose\tO\nlevels\tO\n,\tO\nwith\tO\nobjective\tO\nresponses\tO\nin\tO\n17\tO\n(\tO\ntwo\tO\ncomplete\tO\nand\tO\n15\tO\npartial\tO\nregressions\tO\n)\tO\nof\tO\n41\tO\npreviously\tO\nuntreated\tO\npatients\tO\n.\tO\n\nToxicities\tB-Disease\nwere\tO\ncompared\tO\nwith\tO\na\tO\ncohort\tO\nof\tO\npatients\tO\nin\tO\na\tO\nphase\tO\nI\tO\ntrial\tO\nof\tO\npaclitaxel\tB-Chemical\nalone\tO\nat\tO\nidentical\tO\ndose\tO\nlevels\tO\n.\tO\n\nCarboplatin\tB-Chemical\ndid\tO\nnot\tO\nappear\tO\nto\tO\nadd\tO\nto\tO\nthe\tO\nhematologic\tB-Disease\ntoxicities\tI-Disease\nobserved\tO\n,\tO\nand\tO\nthe\tO\npaclitaxel\tB-Chemical\n/\tO\ncarboplatin\tB-Chemical\ncombination\tO\ncould\tO\nbe\tO\ndosed\tO\nevery\tO\n3\tO\nweeks\tO\n.\tO\n\nThe\tO\ndose\tO\n-\tO\ndependent\tO\neffect\tO\nof\tO\nmisoprostol\tB-Chemical\non\tO\nindomethacin\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\nin\tO\nwell\tO\ncompensated\tO\ncirrhosis\tB-Disease\n.\tO\n\nMisoprostol\tB-Chemical\n(\tO\n200\tO\nmicrograms\tO\n)\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nacutely\tO\ncounteract\tO\nthe\tO\nindomethacin\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\nin\tO\nwell\tO\ncompensated\tO\ncirrhotic\tB-Disease\npatients\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nif\tO\nthe\tO\nprophylactic\tO\nvalue\tO\nof\tO\nmisoprostol\tB-Chemical\nwas\tO\ndose\tO\n-\tO\ndependent\tO\n.\tO\n\nParameters\tO\nof\tO\nrenal\tO\nhemodynamics\tO\nand\tO\ntubular\tO\nsodium\tB-Chemical\nand\tO\nwater\tO\nhandling\tO\nwere\tO\nassessed\tO\nby\tO\nclearance\tO\ntechniques\tO\nin\tO\n26\tO\nwell\tO\ncompensated\tO\ncirrhotic\tB-Disease\npatients\tO\nbefore\tO\nand\tO\nafter\tO\nan\tO\noral\tO\ncombination\tO\nof\tO\n50\tO\nmg\tO\nof\tO\nindomethacin\tB-Chemical\nand\tO\nvarious\tO\ndoses\tO\nof\tO\nmisoprostol\tB-Chemical\n.\tO\n\nThe\tO\n200\tO\n-\tO\nmicrograms\tO\ndose\tO\nwas\tO\nable\tO\nto\tO\ntotally\tO\nabolish\tO\nthe\tO\ndeleterious\tO\nrenal\tO\neffects\tO\nof\tO\nindomethacin\tB-Chemical\n,\tO\nwhereas\tO\nthe\tO\n800\tO\n-\tO\nmicrograms\tO\ndose\tO\nresulted\tO\nin\tO\nsignificant\tO\nworsening\tO\nof\tO\nrenal\tO\nhemodynamics\tO\nand\tO\nsodium\tB-Chemical\nretention\tO\n.\tO\n\nThese\tO\nchanges\tO\nwere\tO\nmaximal\tO\nin\tO\nthe\tO\nhour\tO\nimmediately\tO\nafter\tO\nmedications\tO\nand\tO\nslowly\tO\nreturned\tO\ntoward\tO\nbase\tO\n-\tO\nline\tO\nlevels\tO\nthereafter\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nthe\tO\nrenal\tO\nprotective\tO\neffects\tO\nof\tO\nmisoprostol\tB-Chemical\nis\tO\ndose\tO\n-\tO\ndependent\tO\n.\tO\n\nHowever\tO\n,\tO\nuntil\tO\nthis\tO\napparent\tO\nability\tO\nof\tO\n200\tO\nmicrograms\tO\nof\tO\nmisoprostol\tB-Chemical\nto\tO\nprevent\tO\nthe\tO\nadverse\tO\neffects\tO\nof\tO\nindomethacin\tB-Chemical\non\tO\nrenal\tO\nfunction\tO\nis\tO\nconfirmed\tO\nwith\tO\nchronic\tO\nfrequent\tO\ndosing\tO\n,\tO\nit\tO\nwould\tO\nbe\tO\nprudent\tO\nto\tO\navoid\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\ntherapy\tO\nin\tO\npatients\tO\nwith\tO\ncirrhosis\tB-Disease\n.\tO\n\nIncreased\tO\nfrequency\tO\nand\tO\nseverity\tO\nof\tO\nangio\tB-Disease\n-\tI-Disease\noedema\tI-Disease\nrelated\tO\nto\tO\nlong\tO\n-\tO\nterm\tO\ntherapy\tO\nwith\tO\nangiotensin\tB-Chemical\n-\tI-Chemical\nconverting\tI-Chemical\nenzyme\tI-Chemical\ninhibitor\tI-Chemical\nin\tO\ntwo\tO\npatients\tO\n.\tO\n\nAdverse\tO\nreactions\tO\nto\tO\ndrugs\tO\nare\tO\nwell\tO\nrecognized\tO\nas\tO\na\tO\ncause\tO\nof\tO\nacute\tO\nor\tO\nchronic\tO\nurticaria\tB-Disease\n,\tO\nand\tO\nangio\tB-Disease\n-\tI-Disease\noedema\tI-Disease\n.\tO\n\nAngiotensin\tB-Chemical\n-\tI-Chemical\nconverting\tI-Chemical\nenzyme\tI-Chemical\n(\tI-Chemical\nACE\tI-Chemical\n)\tI-Chemical\ninhibitors\tI-Chemical\n,\tO\nused\tO\nto\tO\ntreat\tO\nhypertension\tB-Disease\nand\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n,\tO\nwere\tO\nintroduced\tO\nin\tO\nEurope\tO\nin\tO\nthe\tO\nmiddle\tO\nof\tO\nthe\tO\neighties\tO\n,\tO\nand\tO\nthe\tO\nuse\tO\nof\tO\nthese\tO\ndrugs\tO\nhas\tO\nincreased\tO\nprogressively\tO\n.\tO\n\nSoon\tO\nafter\tO\nthe\tO\nintroduction\tO\nof\tO\nACE\tB-Chemical\ninhibitors\tI-Chemical\n,\tO\nacute\tO\nbouts\tO\nof\tO\nangio\tB-Disease\n-\tI-Disease\noedema\tI-Disease\nwere\tO\nreported\tO\nin\tO\nassociation\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nthese\tO\ndrugs\tO\n.\tO\n\nWe\tO\nwish\tO\nto\tO\ndraw\tO\nattention\tO\nto\tO\nthe\tO\npossibility\tO\nof\tO\nadverse\tO\nreactions\tO\nto\tO\nACE\tB-Chemical\ninhibitors\tI-Chemical\nafter\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nand\tO\nin\tO\npatients\tO\nwith\tO\npre\tO\n-\tO\nexisting\tO\nangio\tB-Disease\n-\tI-Disease\noedema\tI-Disease\n.\tO\n\nMyoclonus\tB-Disease\nassociated\tO\nwith\tO\nlorazepam\tB-Chemical\ntherapy\tO\nin\tO\nvery\tO\n-\tO\nlow\tO\n-\tO\nbirth\tO\n-\tO\nweight\tO\ninfants\tO\n.\tO\n\nLorazepam\tB-Chemical\nis\tO\nbeing\tO\nused\tO\nwith\tO\nincreasing\tO\nfrequency\tO\nas\tO\na\tO\nsedative\tO\nin\tO\nthe\tO\nnewborn\tO\nand\tO\nthe\tO\nyoung\tO\ninfant\tO\n.\tO\n\nConcern\tO\nhas\tO\nbeen\tO\nraised\tO\nwith\tO\nregard\tO\nto\tO\nthe\tO\nsafety\tO\nof\tO\nlorazepam\tB-Chemical\nin\tO\nthis\tO\nage\tO\ngroup\tO\n,\tO\nespecially\tO\nin\tO\nvery\tO\n-\tO\nlow\tO\n-\tO\nbirth\tO\n-\tO\nweight\tO\n(\tO\nVLBW\tO\n;\tO\n<\tO\n1\tO\n,\tO\n500\tO\ng\tO\n)\tO\ninfants\tO\n.\tO\n\nThree\tO\nyoung\tO\ninfants\tO\n,\tO\nall\tO\nof\tO\nbirth\tO\nweight\tO\n<\tO\n1\tO\n,\tO\n500\tO\ng\tO\n,\tO\nexperienced\tO\nmyoclonus\tB-Disease\nfollowing\tO\nthe\tO\nintravenous\tO\nadministration\tO\nof\tO\nlorazepam\tB-Chemical\n.\tO\n\nThe\tO\npotential\tO\nneurotoxic\tB-Disease\neffects\tO\nof\tO\nthe\tO\ndrug\tO\n(\tO\nand\tO\nits\tO\nvehicle\tO\n)\tO\nin\tO\nthis\tO\npopulation\tO\nare\tO\ndiscussed\tO\n.\tO\n\nInjectable\tO\nlorazepam\tB-Chemical\nshould\tO\nbe\tO\nused\tO\nwith\tO\ncaution\tO\nin\tO\nVLBW\tO\ninfants\tO\n.\tO\n\nTransvenous\tO\nright\tO\nventricular\tO\npacing\tO\nduring\tO\ncardiopulmonary\tO\nresuscitation\tO\nof\tO\npediatric\tO\npatients\tO\nwith\tO\nacute\tO\ncardiomyopathy\tB-Disease\n.\tO\n\nWe\tO\ndescribe\tO\nthe\tO\ncardiopulmonary\tO\nresuscitation\tO\nefforts\tO\non\tO\nfive\tO\npatients\tO\nwho\tO\npresented\tO\nin\tO\nacute\tO\ncirculatory\tB-Disease\nfailure\tI-Disease\nfrom\tO\nmyocardial\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nThree\tO\npatients\tO\nhad\tO\nacute\tO\nviral\tO\nmyocarditis\tB-Disease\n,\tO\none\tO\nhad\tO\na\tO\ncarbamazepine\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\neosinophilic\tB-Disease\nmyocarditis\tI-Disease\n,\tO\nand\tO\none\tO\nhad\tO\ncardiac\tO\nhemosiderosis\tO\nresulting\tO\nin\tO\nacute\tO\ncardiogenic\tB-Disease\nshock\tI-Disease\n.\tO\n\nAll\tO\npatients\tO\nwere\tO\ncontinuously\tO\nmonitored\tO\nwith\tO\ncentral\tO\nvenous\tO\nand\tO\narterial\tO\ncatheters\tO\nin\tO\naddition\tO\nto\tO\nroutine\tO\nnoninvasive\tO\nmonitoring\tO\n.\tO\n\nAn\tO\nintroducer\tO\nsheath\tO\n,\tO\na\tO\npacemaker\tO\n,\tO\nand\tO\nsterile\tO\npacing\tO\nwires\tO\nwere\tO\nmade\tO\nreadily\tO\navailable\tO\nfor\tO\nthe\tO\npatients\tO\n,\tO\nshould\tO\nthe\tO\nneed\tO\narise\tO\nto\tO\nterminate\tO\nresistant\tO\ncardiac\tO\ndysrhythmias\tB-Disease\n.\tO\n\nAll\tO\npatients\tO\ndeveloped\tO\ncardiocirculatory\tO\narrest\tO\nassociated\tO\nwith\tO\nextreme\tO\nhypotension\tB-Disease\nand\tO\ndysrhythmias\tB-Disease\nwithin\tO\nthe\tO\nfirst\tO\n48\tO\nhours\tO\nof\tO\ntheir\tO\nadmission\tO\nto\tO\nthe\tO\npediatric\tO\nintensive\tO\ncare\tO\nunit\tO\n(\tO\nPICU\tO\n)\tO\n.\tO\n\nRight\tO\nventricular\tO\npacemaker\tO\nwires\tO\nwere\tO\ninserted\tO\nin\tO\nall\tO\nof\tO\nthem\tO\nduring\tO\ncardiopulmonary\tO\nresuscitation\tO\n(\tO\nCPR\tO\n)\tO\n.\tO\n\nIn\tO\nfour\tO\npatients\tO\n,\tO\ncardiac\tO\npacing\tO\nwas\tO\nused\tO\n,\tO\nresulting\tO\nin\tO\na\tO\ntemporary\tO\ncaptured\tO\nrhythm\tO\nand\tO\nrestoration\tO\nof\tO\ntheir\tO\ncardiac\tO\noutput\tO\n.\tO\n\nThese\tO\npatients\tO\nhad\tO\na\tO\nsecond\tO\nevent\tO\nof\tO\ncardiac\tB-Disease\narrest\tI-Disease\n,\tO\nresulting\tO\nin\tO\ndeath\tO\n,\tO\nwithin\tO\n10\tO\nto\tO\n60\tO\nminutes\tO\n.\tO\n\nIn\tO\none\tO\npatient\tO\n,\tO\ncardiac\tO\npacing\tO\nwas\tO\nnot\tO\nused\tO\n,\tO\nbecause\tO\nhe\tO\nconverted\tO\nto\tO\nnormal\tO\nsinus\tO\nrhythm\tO\nby\tO\nelectrical\tO\ndefibrillation\tO\nwithin\tO\nthree\tO\nminutes\tO\nof\tO\ninitiating\tO\nCPR\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\ncardiac\tO\npacing\tO\nduring\tO\nresuscitative\tO\nefforts\tO\nin\tO\npediatric\tO\npatients\tO\nsuffering\tO\nfrom\tO\nacute\tO\nmyocardial\tB-Disease\ndysfunction\tI-Disease\nmay\tO\nnot\tO\nhave\tO\nlong\tO\n-\tO\nterm\tO\nvalue\tO\nin\tO\nand\tO\nof\tO\nitself\tO\n;\tO\nhowever\tO\n,\tO\nif\tO\ntemporary\tO\nhemodynamic\tO\nstability\tO\nis\tO\nachieved\tO\nby\tO\nthis\tO\nprocedure\tO\n,\tO\nit\tO\nmay\tO\nprovide\tO\nadditional\tO\ntime\tO\nneeded\tO\nto\tO\ninstitute\tO\nother\tO\ntherapeutic\tO\nmodalities\tO\n.\tO\n\nEfficacy\tO\nand\tO\nsafety\tO\nof\tO\ngranisetron\tB-Chemical\n,\tO\na\tO\nselective\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptamine\tI-Chemical\n-\tO\n3\tO\nreceptor\tO\nantagonist\tO\n,\tO\nin\tO\nthe\tO\nprevention\tO\nof\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\ninduced\tO\nby\tO\nhigh\tO\n-\tO\ndose\tO\ncisplatin\tB-Chemical\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nassess\tO\nthe\tO\nantiemetic\tO\neffects\tO\nand\tO\nsafety\tO\nprofile\tO\nof\tO\nfour\tO\ndifferent\tO\ndoses\tO\nof\tO\ngranisetron\tB-Chemical\n(\tO\nKytril\tB-Chemical\n;\tO\nSmithKline\tO\nBeecham\tO\nPharmaceuticals\tO\n,\tO\nPhiladelphia\tO\n,\tO\nPA\tO\n)\tO\nwhen\tO\nadministered\tO\nas\tO\na\tO\nsingle\tO\nintravenous\tO\n(\tO\nIV\tO\n)\tO\ndose\tO\nfor\tO\nprophylaxis\tO\nof\tO\ncisplatin\tB-Chemical\n-\tO\ninduced\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nOne\tO\nhundred\tO\neighty\tO\n-\tO\nfour\tO\nchemotherapy\tO\n-\tO\nnaive\tO\npatients\tO\nreceiving\tO\nhigh\tO\n-\tO\ndose\tO\ncisplatin\tB-Chemical\n(\tO\n81\tO\nto\tO\n120\tO\nmg\tO\n/\tO\nm2\tO\n)\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\none\tO\nof\tO\nfour\tO\ngranisetron\tB-Chemical\ndoses\tO\n(\tO\n5\tO\n,\tO\n10\tO\n,\tO\n20\tO\n,\tO\nor\tO\n40\tO\nmicrograms\tO\n/\tO\nkg\tO\n)\tO\nadministered\tO\nbefore\tO\nchemotherapy\tO\n.\tO\n\nPatients\tO\nwere\tO\nobserved\tO\non\tO\nan\tO\ninpatient\tO\nbasis\tO\nfor\tO\n18\tO\nto\tO\n24\tO\nhours\tO\n,\tO\nand\tO\nvital\tO\nsigns\tO\n,\tO\nnausea\tB-Disease\n,\tO\nvomiting\tB-Disease\n,\tO\nretching\tO\n,\tO\nand\tO\nappetite\tO\nwere\tO\nassessed\tO\n.\tO\n\nSafety\tO\nanalyses\tO\nincluded\tO\nincidence\tO\nof\tO\nadverse\tO\nexperiences\tO\nand\tO\nlaboratory\tO\nparameter\tO\nchanges\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAfter\tO\ngranisetron\tB-Chemical\ndoses\tO\nof\tO\n5\tO\n,\tO\n10\tO\n,\tO\n20\tO\n,\tO\nand\tO\n40\tO\nmicrograms\tO\n/\tO\nkg\tO\n,\tO\na\tO\nmajor\tO\nresponse\tO\n(\tO\n<\tO\nor\tO\n=\tO\ntwo\tO\nvomiting\tB-Disease\nor\tO\nretching\tO\nepisodes\tO\n,\tO\nand\tO\nno\tO\nantiemetic\tO\nrescue\tO\n)\tO\nwas\tO\nrecorded\tO\nin\tO\n23\tO\n%\tO\n,\tO\n57\tO\n%\tO\n,\tO\n58\tO\n%\tO\n,\tO\nand\tO\n60\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nrespectively\tO\n,\tO\nand\tO\na\tO\ncomplete\tO\nresponse\tO\n(\tO\nno\tO\nvomiting\tB-Disease\nor\tO\nretching\tO\n,\tO\nand\tO\nno\tO\nantiemetic\tO\nrescue\tO\n)\tO\nin\tO\n18\tO\n%\tO\n,\tO\n41\tO\n%\tO\n,\tO\n40\tO\n%\tO\n,\tO\nand\tO\n47\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nrespectively\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nstatistically\tO\nlonger\tO\ntime\tO\nto\tO\nfirst\tO\nepisode\tO\nof\tO\nnausea\tB-Disease\n(\tO\nP\tO\n=\tO\n.\tO\n0015\tO\n)\tO\nand\tO\nvomiting\tB-Disease\n(\tO\nP\tO\n=\tO\n.\tO\n0001\tO\n)\tO\n,\tO\nand\tO\nfewer\tO\npatients\tO\nwere\tO\nadministered\tO\nadditional\tO\nantiemetic\tO\nmedication\tO\nin\tO\nthe\tO\n10\tO\n-\tO\nmicrograms\tO\n/\tO\nkg\tO\ndosing\tO\ngroups\tO\nthan\tO\nin\tO\nthe\tO\n5\tO\n-\tO\nmicrograms\tO\n/\tO\nkg\tO\ndosing\tO\ngroup\tO\n.\tO\n\nAs\tO\ngranisetron\tB-Chemical\ndose\tO\nincreased\tO\n,\tO\nappetite\tO\nreturn\tO\nincreased\tO\n(\tO\nP\tO\n=\tO\n.\tO\n040\tO\n)\tO\n.\tO\n\nHeadache\tB-Disease\nwas\tO\nthe\tO\nmost\tO\nfrequently\tO\nreported\tO\nadverse\tO\nevent\tO\n(\tO\n20\tO\n%\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nA\tO\nsingle\tO\n10\tO\n-\tO\n,\tO\n20\tO\n-\tO\n,\tO\nor\tO\n40\tO\n-\tO\nmicrograms\tO\n/\tO\nkg\tO\ndose\tO\nof\tO\ngranisetron\tB-Chemical\nwas\tO\neffective\tO\nin\tO\ncontrolling\tO\nvomiting\tB-Disease\nin\tO\n57\tO\n%\tO\nto\tO\n60\tO\n%\tO\nof\tO\npatients\tO\nwho\tO\nreceived\tO\ncisplatin\tB-Chemical\nat\tO\ndoses\tO\ngreater\tO\nthan\tO\n81\tO\nmg\tO\n/\tO\nm2\tO\nand\tO\ntotally\tO\nprevented\tO\nvomiting\tB-Disease\nin\tO\n40\tO\n%\tO\nto\tO\n47\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nstatistically\tO\nsignificant\tO\ndifferences\tO\nin\tO\nefficacy\tO\nbetween\tO\nthe\tO\n10\tO\n-\tO\nmicrograms\tO\n/\tO\nkg\tO\ndose\tO\nand\tO\nthe\tO\n20\tO\n-\tO\nand\tO\n40\tO\n-\tO\nmicrograms\tO\n/\tO\nkg\tO\ndoses\tO\n.\tO\n\nGranisetron\tB-Chemical\nwas\tO\nwell\tO\ntolerated\tO\nat\tO\nall\tO\ndoses\tO\n.\tO\n\nAdverse\tO\ninteraction\tO\nbetween\tO\nclonidine\tB-Chemical\nand\tO\nverapamil\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\ntwo\tO\ncases\tO\nof\tO\na\tO\npossible\tO\nadverse\tO\ninteraction\tO\nbetween\tO\nclonidine\tB-Chemical\nand\tO\nverapamil\tB-Chemical\nresulting\tO\nin\tO\natrioventricular\tB-Disease\n(\tI-Disease\nAV\tI-Disease\n)\tI-Disease\nblock\tI-Disease\nin\tO\nboth\tO\npatients\tO\nand\tO\nsevere\tO\nhypotension\tB-Disease\nin\tO\none\tO\npatient\tO\n.\tO\n\nCASE\tO\nSUMMARIES\tO\n:\tO\nA\tO\n54\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nhyperaldosteronism\tB-Disease\nwas\tO\ntreated\tO\nwith\tO\nverapamil\tB-Chemical\n480\tO\nmg\tO\n/\tO\nd\tO\nand\tO\nspironolactone\tB-Chemical\n100\tO\nmg\tO\n/\tO\nd\tO\n.\tO\n\nAfter\tO\nthe\tO\naddition\tO\nof\tO\na\tO\nminimal\tO\ndose\tO\nof\tO\nclonidine\tB-Chemical\n(\tO\n0\tO\n.\tO\n15\tO\nmg\tO\nbid\tO\n)\tO\n,\tO\nshe\tO\ndeveloped\tO\ncomplete\tO\nAV\tB-Disease\nblock\tI-Disease\nand\tO\nsevere\tO\nhypotension\tB-Disease\n,\tO\nwhich\tO\nresolved\tO\nupon\tO\ncessation\tO\nof\tO\nall\tO\nmedications\tO\n.\tO\n\nA\tO\n65\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwas\tO\ntreated\tO\nwith\tO\nextended\tO\n-\tO\nrelease\tO\nverapamil\tB-Chemical\n240\tO\nmg\tO\n/\tO\nd\tO\n.\tO\n\nAfter\tO\nthe\tO\naddition\tO\nof\tO\nclonidine\tB-Chemical\n0\tO\n.\tO\n15\tO\nmg\tO\nbid\tO\nshe\tO\ndeveloped\tO\ncomplete\tO\nAV\tB-Disease\nblock\tI-Disease\n,\tO\nwhich\tO\nresolved\tO\nafter\tO\nall\tO\ntherapy\tO\nwas\tO\nstopped\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nAn\tO\nadverse\tO\ninteraction\tO\nbetween\tO\nclonidine\tB-Chemical\nand\tO\nverapamil\tB-Chemical\nhas\tO\nnot\tO\nbeen\tO\nreported\tO\npreviously\tO\n.\tO\n\nWe\tO\ndescribe\tO\ntwo\tO\nsuch\tO\ncases\tO\nand\tO\ndiscuss\tO\nthe\tO\nvarious\tO\nmechanisms\tO\nthat\tO\nmight\tO\ncause\tO\nsuch\tO\nan\tO\ninteraction\tO\n.\tO\n\nClinicians\tO\nshould\tO\nbe\tO\nacquainted\tO\nwith\tO\nthis\tO\npossibly\tO\nfatal\tO\ninteraction\tO\nbetween\tO\ntwo\tO\ncommonly\tO\nused\tO\nantihypertensive\tO\ndrugs\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCaution\tO\nis\tO\nrecommended\tO\nin\tO\ncombining\tO\nclonidine\tB-Chemical\nand\tO\nverapamil\tB-Chemical\ntherapy\tO\n,\tO\neven\tO\nin\tO\npatients\tO\nwho\tO\ndo\tO\nnot\tO\nhave\tO\nsinus\tO\nor\tO\nAV\tO\nnode\tO\ndysfunction\tO\n.\tO\n\nThe\tO\ntwo\tO\ndrugs\tO\nmay\tO\nact\tO\nsynergistically\tO\non\tO\nboth\tO\nthe\tO\nAV\tO\nnode\tO\nand\tO\nthe\tO\nperipheral\tO\ncirculation\tO\n.\tO\n\nPharmacological\tO\nstudies\tO\non\tO\na\tO\nnew\tO\ndihydrothienopyridine\tB-Chemical\ncalcium\tI-Chemical\nantagonist\tO\n,\tO\nS\tB-Chemical\n-\tI-Chemical\n312\tI-Chemical\n-\tI-Chemical\nd\tI-Chemical\n.\tO\n\n5th\tO\ncommunication\tO\n:\tO\nanticonvulsant\tO\neffects\tO\nin\tO\nmice\tO\n.\tO\n\nS\tB-Chemical\n-\tI-Chemical\n312\tI-Chemical\n,\tO\nS\tB-Chemical\n-\tI-Chemical\n312\tI-Chemical\n-\tI-Chemical\nd\tI-Chemical\n,\tO\nbut\tO\nnot\tO\nS\tB-Chemical\n-\tI-Chemical\n312\tI-Chemical\n-\tI-Chemical\nl\tI-Chemical\n,\tO\nL\tO\n-\tO\ntype\tO\ncalcium\tB-Chemical\nchannel\tO\nantagonists\tO\n,\tO\nshowed\tO\nanticonvulsant\tO\neffects\tO\non\tO\nthe\tO\naudiogenic\tB-Disease\ntonic\tI-Disease\nconvulsions\tI-Disease\nin\tO\nDBA\tO\n/\tO\n2\tO\nmice\tO\n;\tO\nand\tO\ntheir\tO\nED50\tO\nvalues\tO\nwere\tO\n18\tO\n.\tO\n4\tO\n(\tO\n12\tO\n.\tO\n8\tO\n-\tO\n27\tO\n.\tO\n1\tO\n)\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\nand\tO\n15\tO\n.\tO\n0\tO\n(\tO\n10\tO\n.\tO\n2\tO\n-\tO\n23\tO\n.\tO\n7\tO\n)\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n,\tO\nrespectively\tO\n,\tO\nwhile\tO\nthat\tO\nof\tO\nflunarizine\tB-Chemical\nwas\tO\n34\tO\n.\tO\n0\tO\n(\tO\n26\tO\n.\tO\n0\tO\n-\tO\n44\tO\n.\tO\n8\tO\n)\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n\nAlthough\tO\nmoderate\tO\nanticonvulsant\tO\neffects\tO\nof\tO\nS\tB-Chemical\n-\tI-Chemical\n312\tI-Chemical\n-\tI-Chemical\nd\tI-Chemical\nin\tO\nhigher\tO\ndoses\tO\nwere\tO\nobserved\tO\nagainst\tO\nthe\tO\nclonic\tO\nconvulsions\tB-Disease\ninduced\tO\nby\tO\npentylenetetrazole\tB-Chemical\n(\tO\n85\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nor\tO\nbemegride\tB-Chemical\n(\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\n,\tO\nno\tO\neffects\tO\nwere\tO\nobserved\tO\nin\tO\nconvulsions\tB-Disease\ninduced\tO\nby\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n,\tO\npicrotoxin\tB-Chemical\n,\tO\nor\tO\nelectroshock\tO\nin\tO\nSlc\tO\n:\tO\nddY\tO\nmice\tO\n.\tO\n\nS\tB-Chemical\n-\tI-Chemical\n312\tI-Chemical\n-\tI-Chemical\nd\tI-Chemical\nmay\tO\nbe\tO\nuseful\tO\nin\tO\nthe\tO\ntherapy\tO\nof\tO\ncertain\tO\ntypes\tO\nof\tO\nhuman\tO\nepilepsy\tB-Disease\n.\tO\n\nTransmural\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwith\tO\nsumatriptan\tB-Chemical\n.\tO\n\nFor\tO\nsumatriptan\tB-Chemical\n,\tO\ntightness\tO\nin\tO\nthe\tO\nchest\tO\ncaused\tO\nby\tO\nan\tO\nunknown\tO\nmechanism\tO\nhas\tO\nbeen\tO\nreported\tO\nin\tO\n3\tO\n-\tO\n5\tO\n%\tO\nof\tO\nusers\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n47\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nan\tO\nacute\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nafter\tO\nadministration\tO\nof\tO\nsumatriptan\tB-Chemical\n6\tO\nmg\tO\nsubcutaneously\tO\nfor\tO\ncluster\tB-Disease\nheadache\tI-Disease\n.\tO\n\nThe\tO\npatient\tO\nhad\tO\nno\tO\nhistory\tO\nof\tO\nunderlying\tO\nischaemic\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\nor\tO\nPrinzmetal\tB-Disease\n'\tI-Disease\ns\tI-Disease\nangina\tI-Disease\n.\tO\n\nShe\tO\nrecovered\tO\nwithout\tO\ncomplications\tO\n.\tO\n\nFlumazenil\tB-Chemical\ninduces\tO\nseizures\tB-Disease\nand\tO\ndeath\tO\nin\tO\nmixed\tO\ncocaine\tB-Chemical\n-\tO\ndiazepam\tB-Chemical\nintoxications\tO\n.\tO\n\nSTUDY\tO\nHYPOTHESIS\tO\n:\tO\nAdministration\tO\nof\tO\nthe\tO\nbenzodiazepine\tB-Chemical\nantagonist\tO\nflumazenil\tB-Chemical\nmay\tO\nunmask\tO\nseizures\tB-Disease\nin\tO\nmixed\tO\ncocaine\tB-Chemical\n-\tO\nbenzodiazepine\tB-Chemical\nintoxication\tO\n.\tO\n\nDESIGN\tO\n:\tO\nMale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nreceived\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\ncocaine\tB-Chemical\nIP\tO\nalone\tO\n,\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ndiazepam\tB-Chemical\nalone\tO\n,\tO\nor\tO\na\tO\ncombination\tO\nof\tO\ndiazepam\tB-Chemical\nand\tO\ncocaine\tB-Chemical\n.\tO\n\nThree\tO\nminutes\tO\nlater\tO\n,\tO\ngroups\tO\nwere\tO\nchallenged\tO\nwith\tO\nvehicle\tO\nor\tO\nflumazenil\tB-Chemical\n5\tO\nor\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nIP\tO\n.\tO\n\nAnimal\tO\nbehavior\tO\n,\tO\nseizures\tB-Disease\n(\tO\ntime\tO\nto\tO\nand\tO\nincidence\tO\n)\tO\n,\tO\ndeath\tO\n(\tO\ntime\tO\nto\tO\nand\tO\nincidence\tO\n)\tO\n,\tO\nand\tO\ncortical\tO\nEEG\tO\ntracings\tO\nwere\tO\nrecorded\tO\n.\tO\n\nINTERVENTIONS\tO\n:\tO\nAdministration\tO\nof\tO\nflumazenil\tB-Chemical\nto\tO\nanimals\tO\nafter\tO\nthey\tO\nhad\tO\nreceived\tO\na\tO\ncombination\tO\ndose\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\ndiazepam\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nIn\tO\ngroup\tO\n1\tO\n,\tO\nanimals\tO\nreceived\tO\ncocaine\tB-Chemical\nfollowed\tO\nby\tO\nvehicle\tO\n.\tO\n\nThis\tO\nresulted\tO\nin\tO\n100\tO\n%\tO\ndeveloping\tO\nseizures\tB-Disease\nand\tO\ndeath\tO\n.\tO\n\nGroup\tO\n2\tO\nreceived\tO\ndiazepam\tB-Chemical\nalone\tO\nfollowed\tO\nby\tO\nvehicle\tO\n.\tO\n\nAnimals\tO\nbecame\tO\nsomnolent\tO\nand\tO\nnone\tO\ndied\tO\n.\tO\n\nGroup\tO\n3\tO\nreceived\tO\ndiazepam\tB-Chemical\nfollowed\tO\nby\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nflumazenil\tB-Chemical\n.\tO\n\nAnimals\tO\nbecame\tO\nsomnolent\tO\nafter\tO\ndiazepam\tB-Chemical\nand\tO\nthen\tO\nactive\tO\nafter\tO\nflumazenil\tB-Chemical\nadministration\tO\n.\tO\n\nIn\tO\ngroup\tO\n4\tO\n,\tO\na\tO\ncombination\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\ndiazepam\tB-Chemical\nwas\tO\nadministered\tO\nsimultaneously\tO\n.\tO\n\nThis\tO\nresulted\tO\nin\tO\nno\tO\novert\tO\nor\tO\nEEG\tO\n-\tO\ndetectable\tO\nseizures\tB-Disease\nand\tO\na\tO\n50\tO\n%\tO\nincidence\tO\nof\tO\ndeath\tO\n.\tO\n\nGroup\tO\n5\tO\nreceived\tO\na\tO\nsimilar\tO\ncombination\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\ndiazepam\tB-Chemical\n,\tO\nfollowed\tO\nlater\tO\nby\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nflumazenil\tB-Chemical\n.\tO\n\nThis\tO\nresulted\tO\nin\tO\nan\tO\nincreased\tO\nincidence\tO\nof\tO\nseizures\tB-Disease\n,\tO\n90\tO\n%\tO\n(\tO\nP\tO\n<\tO\n.\tO\n01\tO\n)\tO\n,\tO\nand\tO\ndeath\tO\n,\tO\n100\tO\n%\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n.\tO\n01\tO\n)\tO\n,\tO\ncompared\tO\nwith\tO\ngroup\tO\n4\tO\n.\tO\n\nGroup\tO\n6\tO\nreceived\tO\ncocaine\tB-Chemical\nand\tO\ndiazepam\tB-Chemical\nfollowed\tO\nby\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nflumazenil\tB-Chemical\n.\tO\n\nThis\tO\nalso\tO\nresulted\tO\nin\tO\nan\tO\nincreased\tO\nincidence\tO\nof\tO\nseizures\tB-Disease\n,\tO\n90\tO\n%\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n.\tO\n01\tO\n)\tO\n,\tO\nand\tO\ndeath\tO\n,\tO\n90\tO\n%\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n.\tO\n05\tO\n)\tO\n,\tO\ncompared\tO\nwith\tO\ngroup\tO\n4\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nFlumazenil\tB-Chemical\ncan\tO\nunmask\tO\nseizures\tB-Disease\nand\tO\nincrease\tO\nthe\tO\nincidence\tO\nof\tO\ndeath\tO\nin\tO\na\tO\nmodel\tO\nof\tO\ncombined\tO\ncocaine\tB-Chemical\n-\tO\ndiazepam\tB-Chemical\nintoxications\tO\n.\tO\n\nMechanisms\tO\nfor\tO\nprotective\tO\neffects\tO\nof\tO\nfree\tO\nradical\tO\nscavengers\tO\non\tO\ngentamicin\tB-Chemical\n-\tO\nmediated\tO\nnephropathy\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nStudies\tO\nwere\tO\nperformed\tO\nto\tO\nexamine\tO\nthe\tO\nmechanisms\tO\nfor\tO\nthe\tO\nprotective\tO\neffects\tO\nof\tO\nfree\tO\nradical\tO\nscavengers\tO\non\tO\ngentamicin\tB-Chemical\n(\tO\nGM\tB-Chemical\n)\tO\n-\tO\nmediated\tO\nnephropathy\tB-Disease\n.\tO\n\nAdministration\tO\nof\tO\nGM\tB-Chemical\nat\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\nfor\tO\n13\tO\ndays\tO\nto\tO\nrats\tO\ninduced\tO\na\tO\nsignificant\tO\nreduction\tO\nin\tO\nrenal\tO\nblood\tO\nflow\tO\n(\tO\nRBF\tO\n)\tO\nand\tO\ninulin\tO\nclearance\tO\n(\tO\nCIn\tO\n)\tO\nas\tO\nwell\tO\nas\tO\nmarked\tO\ntubular\tB-Disease\ndamage\tI-Disease\n.\tO\n\nA\tO\nsignificant\tO\nreduction\tO\nin\tO\nurinary\tO\nguanosine\tB-Chemical\n3\tI-Chemical\n'\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\ncyclic\tI-Chemical\nmonophosphate\tI-Chemical\n(\tO\ncGMP\tB-Chemical\n)\tO\nexcretion\tO\nand\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nrenal\tO\ncortical\tO\nrenin\tO\nand\tO\nendothelin\tO\n-\tO\n1\tO\ncontents\tO\nwere\tO\nalso\tO\nobserved\tO\nin\tO\nGM\tB-Chemical\n-\tO\nmediated\tO\nnephropathy\tB-Disease\n.\tO\n\nSuperoxide\tB-Chemical\ndismutase\tO\n(\tO\nSOD\tO\n)\tO\nor\tO\ndimethylthiourea\tB-Chemical\n(\tO\nDMTU\tB-Chemical\n)\tO\nsignificantly\tO\nlessened\tO\nthe\tO\nGM\tB-Chemical\n-\tO\ninduced\tO\ndecrement\tO\nin\tO\nCIn\tO\n.\tO\n\nThe\tO\nSOD\tO\n-\tO\ninduced\tO\nincrease\tO\nin\tO\nglomerular\tO\nfiltration\tO\nrate\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nmarked\tO\nimprovement\tO\nin\tO\nRBF\tO\n,\tO\nan\tO\nincrease\tO\nin\tO\nurinary\tO\ncGMP\tB-Chemical\nexcretion\tO\n,\tO\nand\tO\na\tO\ndecrease\tO\nin\tO\nrenal\tO\nrenin\tO\nand\tO\nendothelin\tO\n-\tO\n1\tO\ncontent\tO\n.\tO\n\nSOD\tO\ndid\tO\nnot\tO\nattenuate\tO\nthe\tO\ntubular\tB-Disease\ndamage\tI-Disease\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nDMTU\tB-Chemical\nsignificantly\tO\nreduced\tO\nthe\tO\ntubular\tB-Disease\ndamage\tI-Disease\nand\tO\nlipid\tO\nperoxidation\tO\n,\tO\nbut\tO\nit\tO\ndid\tO\nnot\tO\naffect\tO\nrenal\tO\nhemodynamics\tO\nand\tO\nvasoactive\tO\nsubstances\tO\n.\tO\n\nNeither\tO\nSOD\tO\nnor\tO\nDMTU\tB-Chemical\naffected\tO\nthe\tO\nrenal\tO\ncortical\tO\nGM\tB-Chemical\ncontent\tO\nin\tO\nGM\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\n1\tO\n)\tO\nboth\tO\nSOD\tO\nand\tO\nDMTU\tB-Chemical\nhave\tO\nprotective\tO\neffects\tO\non\tO\nGM\tB-Chemical\n-\tO\nmediated\tO\nnephropathy\tB-Disease\n,\tO\n2\tO\n)\tO\nthe\tO\nmechanisms\tO\nfor\tO\nthe\tO\nprotective\tO\neffects\tO\ndiffer\tO\nfor\tO\nSOD\tO\nand\tO\nDMTU\tB-Chemical\n,\tO\nand\tO\n3\tO\n)\tO\nsuperoxide\tB-Chemical\nanions\tO\nplay\tO\na\tO\ncritical\tO\nrole\tO\nin\tO\nGM\tB-Chemical\n-\tO\ninduced\tO\nrenal\tO\nvasoconstriction\tO\n.\tO\n\nCephalothin\tB-Chemical\n-\tO\ninduced\tO\nimmune\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nA\tO\npatient\tO\nwith\tO\nrenal\tB-Disease\ndisease\tI-Disease\ndeveloped\tO\nCoombs\tO\n-\tO\npositive\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nwhile\tO\nreceiving\tO\ncephalothin\tB-Chemical\ntherapy\tO\n.\tO\n\nAn\tO\nanti\tO\n-\tO\ncephalothin\tB-Chemical\nIgG\tO\nantibody\tO\nwas\tO\ndetected\tO\nin\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nserum\tO\nand\tO\nin\tO\nthe\tO\neluates\tO\nfrom\tO\nher\tO\nerythrocytes\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nnonimmunologic\tO\nbinding\tO\nof\tO\nnormal\tO\nand\tO\npatient\tO\n'\tO\ns\tO\nserum\tO\nproteins\tO\nto\tO\nher\tO\nown\tO\nand\tO\ncephalothin\tB-Chemical\n-\tO\ncoated\tO\nnormal\tO\nred\tO\ncells\tO\nwas\tO\ndemonstrated\tO\n.\tO\n\nSkin\tO\ntests\tO\nand\tO\nin\tO\nvitro\tO\nlymphocyte\tO\nstimulation\tO\nrevealed\tO\nthat\tO\nthe\tO\npatient\tO\nwas\tO\nsensitized\tO\nto\tO\ncephalothin\tB-Chemical\nand\tO\nalso\tO\nto\tO\nampicillin\tB-Chemical\n.\tO\n\nCareful\tO\ninvestigation\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemias\tI-Disease\nreveals\tO\nthe\tO\ncomplexity\tO\nof\tO\nthe\tO\nimmune\tO\nmechanisms\tO\ninvolved\tO\n.\tO\n\nAssessment\tO\nof\tO\ncardiomyocyte\tO\nDNA\tO\nsynthesis\tO\nduring\tO\nhypertrophy\tB-Disease\nin\tO\nadult\tO\nmice\tO\n.\tO\n\nThe\tO\nability\tO\nof\tO\ncardiomyocytes\tO\nto\tO\nsynthesize\tO\nDNA\tO\nin\tO\nresponse\tO\nto\tO\nexperimentally\tO\ninduced\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\nwas\tO\nassessed\tO\nin\tO\nadult\tO\nmice\tO\n.\tO\n\nIsoproterenol\tB-Chemical\ndelivered\tO\nby\tO\nosmotic\tO\nminipump\tO\nimplantation\tO\nin\tO\nadult\tO\nC3Heb\tO\n/\tO\nFeJ\tO\nmice\tO\nresulted\tO\nin\tO\na\tO\n46\tO\n%\tO\nincrease\tO\nin\tO\nheart\tO\nweight\tO\nand\tO\na\tO\n19\tO\n.\tO\n3\tO\n%\tO\nincrease\tO\nin\tO\ncardiomyocyte\tO\narea\tO\n.\tO\n\nNo\tO\nDNA\tO\nsynthesis\tO\n,\tO\nas\tO\nassessed\tO\nby\tO\nautoradiographic\tO\nanalysis\tO\nof\tO\nisolated\tO\ncardiomyocytes\tO\n,\tO\nwas\tO\nobserved\tO\nin\tO\ncontrol\tO\nor\tO\nhypertrophic\tB-Disease\nhearts\tI-Disease\n.\tO\n\nA\tO\nsurvey\tO\nof\tO\n15\tO\nindependent\tO\ninbred\tO\nstrains\tO\nof\tO\nmice\tO\nrevealed\tO\nthat\tO\nventricular\tO\ncardiomyocyte\tO\nnuclear\tO\nnumber\tO\nranged\tO\nfrom\tO\n3\tO\nto\tO\n13\tO\n%\tO\nmononucleate\tO\n,\tO\nsuggesting\tO\nthat\tO\ncardiomyocyte\tO\nterminal\tO\ndifferentiation\tO\nis\tO\ninfluenced\tO\ndirectly\tO\nor\tO\nindirectly\tO\nby\tO\ngenetic\tO\nbackground\tO\n.\tO\n\nTo\tO\ndetermine\tO\nwhether\tO\nthe\tO\ncapacity\tO\nfor\tO\nreactive\tO\nDNA\tO\nsynthesis\tO\nwas\tO\nalso\tO\nsubject\tO\nto\tO\ngenetic\tO\nregulation\tO\n,\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\nwas\tO\ninduced\tO\nin\tO\nthe\tO\nstrains\tO\nof\tO\nmice\tO\ncomprising\tO\nthe\tO\nextremes\tO\nof\tO\nthe\tO\nnuclear\tO\nnumber\tO\nsurvey\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nadult\tO\nmouse\tO\natrial\tO\nand\tO\nventricular\tO\ncardiomyocytes\tO\ndo\tO\nnot\tO\nsynthesize\tO\nDNA\tO\nin\tO\nresponse\tO\nto\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\n.\tO\n\nCentral\tO\ncardiovascular\tO\neffects\tO\nof\tO\nAVP\tB-Chemical\nand\tO\nANP\tO\nin\tO\nnormotensive\tO\nand\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ncompare\tO\ninfluence\tO\nof\tO\ncentral\tO\narginine\tB-Chemical\nvasopressin\tI-Chemical\n(\tO\nAVP\tB-Chemical\n)\tO\nand\tO\nof\tO\natrial\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nANP\tO\n)\tO\non\tO\ncontrol\tO\nof\tO\narterial\tO\nblood\tO\npressure\tO\n(\tO\nMAP\tO\n)\tO\nand\tO\nheart\tO\nrate\tO\n(\tO\nHR\tO\n)\tO\nin\tO\nnormotensive\tO\n(\tO\nWKY\tO\n)\tO\nand\tO\nspontaneously\tO\nhypertensive\tB-Disease\n(\tO\nSHR\tO\n)\tO\nrats\tO\n.\tO\n\nThree\tO\nseries\tO\nof\tO\nexperiments\tO\nwere\tO\nperformed\tO\non\tO\n30\tO\nWKY\tO\nand\tO\n30\tO\nSHR\tO\n,\tO\nchronically\tO\ninstrumented\tO\nwith\tO\nguide\tO\ntubes\tO\nin\tO\nthe\tO\nlateral\tO\nventricle\tO\n(\tO\nLV\tO\n)\tO\nand\tO\narterial\tO\nand\tO\nvenous\tO\ncatheters\tO\n.\tO\n\nMAP\tO\nand\tO\nHR\tO\nwere\tO\nmonitored\tO\nbefore\tO\nand\tO\nafter\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninjections\tO\nof\tO\neither\tO\nvehicle\tO\nor\tO\n1\tO\n,\tO\n10\tO\nand\tO\n50\tO\nng\tO\nof\tO\nAVP\tB-Chemical\nand\tO\n25\tO\n,\tO\n125\tO\nand\tO\n500\tO\nng\tO\nof\tO\nANP\tO\n.\tO\n\nSensitivity\tO\nof\tO\ncardiac\tO\ncomponent\tO\nof\tO\nbaroreflex\tO\n(\tO\nCCB\tO\n)\tO\n,\tO\nexpressed\tO\nas\tO\na\tO\nslope\tO\nof\tO\nthe\tO\nregression\tO\nline\tO\nwas\tO\ndetermined\tO\nfrom\tO\nrelationships\tO\nbetween\tO\nsystolic\tO\narterial\tO\npressure\tO\n(\tO\nSAP\tO\n)\tO\nand\tO\nHR\tO\nperiod\tO\n(\tO\nHRp\tO\n)\tO\nduring\tO\nphenylephrine\tB-Chemical\n(\tO\nPhe\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nhypertension\tB-Disease\nand\tO\nsodium\tB-Chemical\nnitroprusside\tI-Chemical\n(\tO\nSN\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nCCB\tO\nwas\tO\nmeasured\tO\nbefore\tO\nand\tO\nafter\tO\nadministration\tO\nof\tO\neither\tO\nvehicle\tO\n,\tO\nAVP\tB-Chemical\n,\tO\nANP\tO\n,\tO\nor\tO\nboth\tO\npeptides\tO\ntogether\tO\n.\tO\n\nIncreases\tO\nof\tO\nMAP\tO\noccurred\tO\nafter\tO\nLV\tO\nadministration\tO\nof\tO\n1\tO\n,\tO\n10\tO\nand\tO\n50\tO\nng\tO\nof\tO\nAVP\tB-Chemical\nin\tO\nWKY\tO\nand\tO\nof\tO\n10\tO\nand\tO\n50\tO\nng\tO\nin\tO\nSHR\tO\n.\tO\n\nANP\tO\ndid\tO\nnot\tO\ncause\tO\nsignificant\tO\nchanges\tO\nin\tO\nMAP\tO\nin\tO\nboth\tO\nstrains\tO\nas\tO\ncompared\tO\nto\tO\nvehicle\tO\n,\tO\nbut\tO\nit\tO\nabolished\tO\nAVP\tB-Chemical\n-\tO\ninduced\tO\nMAP\tO\nincrease\tO\nin\tO\nWKY\tO\nand\tO\nSHR\tO\n.\tO\n\nCCB\tO\nwas\tO\nreduced\tO\nin\tO\nWKY\tO\nand\tO\nSHR\tO\nafter\tO\nLV\tO\nadministration\tO\nof\tO\nAVP\tB-Chemical\nduring\tO\nSN\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nIn\tO\nSHR\tO\nbut\tO\nnot\tO\nin\tO\nWKY\tO\nadministration\tO\nof\tO\nANP\tO\n,\tO\nAVP\tB-Chemical\nand\tO\nANP\tO\n+\tO\nAVP\tB-Chemical\ndecreased\tO\nCCB\tO\nduring\tO\nPhe\tB-Chemical\n-\tO\ninduced\tO\nMAP\tO\nelevation\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\ncentrally\tO\napplied\tO\nAVP\tB-Chemical\nand\tO\nANP\tO\nexert\tO\ndifferential\tO\neffects\tO\non\tO\nblood\tO\npressure\tO\nand\tO\nbaroreflex\tO\ncontrol\tO\nof\tO\nheart\tO\nrate\tO\nin\tO\nWKY\tO\nand\tO\nSHR\tO\nand\tO\nsuggest\tO\ninteraction\tO\nof\tO\nthese\tO\ntwo\tO\npeptides\tO\nin\tO\nblood\tO\npressure\tO\nregulation\tO\nat\tO\nthe\tO\nlevel\tO\nof\tO\ncentral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nCutaneous\tO\nexposure\tO\nto\tO\nwarfarin\tB-Chemical\n-\tO\nlike\tO\nanticoagulant\tO\ncausing\tO\nan\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nintercerebral\tO\nhematoma\tB-Disease\ndue\tO\nto\tO\nwarfarin\tB-Chemical\n-\tO\ninduced\tO\ncoagulopathy\tB-Disease\nis\tO\npresented\tO\n.\tO\n\nThe\tO\n39\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nhad\tO\nspread\tO\na\tO\nwarfarin\tB-Chemical\n-\tO\ntype\tO\nrat\tO\npoison\tO\naround\tO\nher\tO\nhouse\tO\nweekly\tO\nusing\tO\nher\tO\nbare\tO\nhands\tO\n,\tO\nwith\tO\nno\tO\nwashing\tO\npost\tO\napplication\tO\n.\tO\n\nPercutaneous\tO\nabsorption\tO\nof\tO\nwarfarin\tB-Chemical\ncausing\tO\ncoagulopathy\tB-Disease\n,\tO\nreported\tO\nthree\tO\ntimes\tO\nin\tO\nthe\tO\npast\tO\n,\tO\nis\tO\na\tO\nsignificant\tO\nrisk\tO\nif\tO\nprotective\tO\nmeasures\tO\n,\tO\nsuch\tO\nas\tO\ngloves\tO\n,\tO\nare\tO\nnot\tO\nused\tO\n.\tO\n\nAn\tO\nadverse\tO\ndrug\tO\ninteraction\tO\nwith\tO\npiroxicam\tB-Chemical\n,\tO\nwhich\tO\nshe\tO\ntook\tO\noccasionally\tO\n,\tO\nmay\tO\nhave\tO\nexacerbated\tO\nthe\tO\ncoagulopathy\tB-Disease\n.\tO\n\nPediatric\tO\nheart\tO\ntransplantation\tO\nwithout\tO\nchronic\tO\nmaintenance\tO\nsteroids\tB-Chemical\n.\tO\n\nFrom\tO\n1986\tO\nto\tO\nFebruary\tO\n1993\tO\n,\tO\n40\tO\nchildren\tO\naged\tO\n2\tO\nmonths\tO\nto\tO\n18\tO\nyears\tO\n(\tO\naverage\tO\nage\tO\n10\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n8\tO\nyears\tO\n)\tO\nunderwent\tO\nheart\tO\ntransplantation\tO\n.\tO\n\nIndications\tO\nfor\tO\ntransplantation\tO\nwere\tO\nidiopathic\tB-Disease\ncardiomyopathy\tI-Disease\n(\tO\n52\tO\n%\tO\n)\tO\n,\tO\ncongenital\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n(\tO\n35\tO\n%\tO\n)\tO\nwith\tO\nand\tO\nwithout\tO\nprior\tO\nrepair\tO\n(\tO\n71\tO\n%\tO\nand\tO\n29\tO\n%\tO\n,\tO\nrespectively\tO\n)\tO\n,\tO\nhypertrophic\tB-Disease\ncardiomyopathy\tI-Disease\n(\tO\n5\tO\n%\tO\n)\tO\n,\tO\nvalvular\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n(\tO\n3\tO\n%\tO\n)\tO\n,\tO\nand\tO\ndoxorubicin\tB-Chemical\ncardiomyopathy\tB-Disease\n(\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nPatients\tO\nwere\tO\nmanaged\tO\nwith\tO\ncyclosporine\tB-Chemical\nand\tO\nazathioprine\tB-Chemical\n.\tO\n\nNo\tO\nprophylaxis\tO\nwith\tO\nantilymphocyte\tO\nglobulin\tO\nwas\tO\nused\tO\n.\tO\n\nSteroids\tB-Chemical\nwere\tO\ngiven\tO\nto\tO\n39\tO\n%\tO\nof\tO\npatients\tO\nfor\tO\nrefractory\tO\nrejection\tO\n,\tO\nbut\tO\nweaning\tO\nwas\tO\nalways\tO\nattempted\tO\nand\tO\ngenerally\tO\nsuccessful\tO\n(\tO\n64\tO\n%\tO\n)\tO\n.\tO\n\nFive\tO\npatients\tO\n(\tO\n14\tO\n%\tO\n)\tO\nreceived\tO\nmaintenance\tO\nsteroids\tB-Chemical\n.\tO\n\nFour\tO\npatients\tO\ndied\tO\nin\tO\nthe\tO\nperioperative\tO\nperiod\tO\nand\tO\none\tO\ndied\tO\n4\tO\nmonths\tO\nlater\tO\n.\tO\n\nThere\tO\nhave\tO\nbeen\tO\nno\tO\ndeaths\tO\nrelated\tO\nto\tO\nrejection\tO\nor\tO\ninfection\tB-Disease\n.\tO\n\nAverage\tO\nfollow\tO\n-\tO\nup\tO\nwas\tO\n36\tO\n+\tO\n/\tO\n-\tO\n19\tO\nmonths\tO\n(\tO\nrange\tO\n1\tO\nto\tO\n65\tO\nmonths\tO\n)\tO\n.\tO\n\nCumulative\tO\nsurvival\tO\nis\tO\n88\tO\n%\tO\nat\tO\n5\tO\nyears\tO\n.\tO\n\nIn\tO\npatients\tO\nless\tO\nthan\tO\n7\tO\nyears\tO\nof\tO\nage\tO\n,\tO\nrejection\tO\nwas\tO\nmonitored\tO\nnoninvasively\tO\n.\tO\n\nIn\tO\nthe\tO\nfirst\tO\npostoperative\tO\nmonth\tO\n,\tO\n89\tO\n%\tO\nof\tO\npatients\tO\nwere\tO\ntreated\tO\nfor\tO\nrejection\tO\n.\tO\n\nFreedom\tO\nfrom\tO\nserious\tO\ninfections\tB-Disease\nwas\tO\n83\tO\n%\tO\nat\tO\n1\tO\nmonth\tO\nand\tO\n65\tO\n%\tO\nat\tO\n1\tO\nyear\tO\n.\tO\n\nCytomegalovirus\tB-Disease\ninfections\tI-Disease\nwere\tO\ntreated\tO\nsuccessfully\tO\nwith\tO\nganciclovir\tB-Chemical\nin\tO\n11\tO\npatients\tO\n.\tO\n\nNo\tO\nimpairment\tO\nof\tO\ngrowth\tO\nwas\tO\nobserved\tO\nin\tO\nchildren\tO\nwho\tO\nunderwent\tO\ntransplantation\tO\ncompared\tO\nwith\tO\na\tO\ncontrol\tO\npopulation\tO\n.\tO\n\nTwenty\tO\n-\tO\none\tO\npatients\tO\n(\tO\n60\tO\n%\tO\n)\tO\nhave\tO\nundergone\tO\nannual\tO\ncatheterizations\tO\nand\tO\nno\tO\nsign\tO\nof\tO\ngraft\tO\natherosclerosis\tB-Disease\nhas\tO\nbeen\tO\nobserved\tO\n.\tO\n\nSeizures\tB-Disease\noccurred\tO\nin\tO\nfive\tO\npatients\tO\n(\tO\n14\tO\n%\tO\n)\tO\nand\tO\nhypertension\tB-Disease\nwas\tO\ntreated\tO\nin\tO\n10\tO\npatients\tO\n(\tO\n28\tO\n%\tO\n)\tO\n.\tO\n\nNo\tO\npatient\tO\nwas\tO\ndisabled\tO\nand\tO\nno\tO\nlymphoproliferative\tB-Disease\ndisorder\tI-Disease\nwas\tO\nobserved\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nDelirium\tB-Disease\nduring\tO\nfluoxetine\tB-Chemical\ntreatment\tO\n.\tO\n\nA\tO\ncase\tO\nreport\tO\n.\tO\n\nThe\tO\ncorrelation\tO\nbetween\tO\nhigh\tO\nserum\tO\ntricyclic\tO\nantidepressant\tO\nconcentrations\tO\nand\tO\ncentral\tO\nnervous\tO\nsystem\tO\nside\tO\neffects\tO\nhas\tO\nbeen\tO\nwell\tO\nestablished\tO\n.\tO\n\nOnly\tO\na\tO\nfew\tO\nreports\tO\nexist\tO\n,\tO\nhowever\tO\n,\tO\non\tO\nthe\tO\nrelationship\tO\nbetween\tO\nthe\tO\nserum\tO\nconcentrations\tO\nof\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitors\tO\n(\tO\nSSRIs\tO\n)\tO\nand\tO\ntheir\tO\ntoxic\tO\neffects\tO\n.\tO\n\nIn\tO\nsome\tO\ncases\tO\n,\tO\na\tO\nhigh\tO\nserum\tO\nconcentration\tO\nof\tO\ncitalopram\tB-Chemical\n(\tO\n>\tO\n600\tO\nnmol\tO\n/\tO\nL\tO\n)\tO\nin\tO\nelderly\tO\npatients\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nincreased\tO\nsomnolence\tB-Disease\nand\tO\nmovement\tB-Disease\ndifficulties\tI-Disease\n.\tO\n\nWidespread\tO\ncognitive\tB-Disease\ndisorders\tI-Disease\n,\tO\nsuch\tO\nas\tO\ndelirium\tB-Disease\n,\tO\nhave\tO\nnot\tO\nbeen\tO\npreviously\tO\nlinked\tO\nwith\tO\nhigh\tO\nblood\tO\nlevels\tO\nof\tO\nSSRIs\tO\n.\tO\n\nIn\tO\nthis\tO\nreport\tO\n,\tO\nwe\tO\ndescribe\tO\na\tO\npatient\tO\nwith\tO\nacute\tO\nhyperkinetic\tB-Disease\ndelirium\tB-Disease\nconnected\tO\nwith\tO\na\tO\nhigh\tO\nserum\tO\ntotal\tO\nfluoxetine\tB-Chemical\n(\tO\nfluoxetine\tB-Chemical\nplus\tO\ndesmethylfluoxetine\tB-Chemical\n)\tO\nconcentration\tO\n.\tO\n\nPulmonary\tB-Disease\nedema\tI-Disease\nand\tO\nshock\tB-Disease\nafter\tO\nhigh\tO\n-\tO\ndose\tO\naracytine\tB-Chemical\n-\tI-Chemical\nC\tI-Chemical\nfor\tO\nlymphoma\tB-Disease\n;\tO\npossible\tO\nrole\tO\nof\tO\nTNF\tO\n-\tO\nalpha\tO\nand\tO\nPAF\tO\n.\tO\n\nFour\tO\nout\tO\nof\tO\n23\tO\nconsecutive\tO\npatients\tO\ntreated\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\nAra\tB-Chemical\n-\tI-Chemical\nC\tI-Chemical\nfor\tO\nlymphomas\tB-Disease\nin\tO\nour\tO\ninstitution\tO\ndeveloped\tO\na\tO\nstrikingly\tO\nsimilar\tO\nsyndrome\tO\nduring\tO\nthe\tO\nperfusion\tO\n.\tO\n\nIt\tO\nwas\tO\ncharacterized\tO\nby\tO\nthe\tO\nonset\tO\nof\tO\nfever\tB-Disease\n,\tO\ndiarrhea\tB-Disease\n,\tO\nshock\tB-Disease\n,\tO\npulmonary\tB-Disease\nedema\tI-Disease\n,\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nmetabolic\tB-Disease\nacidosis\tI-Disease\n,\tO\nweight\tB-Disease\ngain\tI-Disease\nand\tO\nleukocytosis\tB-Disease\n.\tO\n\nThorough\tO\nbacteriological\tO\nscreening\tO\nfailed\tO\nto\tO\nprovide\tO\nevidence\tO\nof\tO\ninfection\tB-Disease\n.\tO\n\nSequential\tO\nbiological\tO\nassays\tO\nof\tO\nIL\tO\n-\tO\n1\tO\n,\tO\nIL\tO\n-\tO\n2\tO\n,\tO\nTNF\tO\nand\tO\nPAF\tO\nwere\tO\nperformed\tO\nduring\tO\nAra\tB-Chemical\n-\tI-Chemical\nC\tI-Chemical\ninfusion\tO\nto\tO\nten\tO\npatients\tO\n,\tO\nincluding\tO\nthe\tO\nfour\tO\nwho\tO\ndeveloped\tO\nthe\tO\nsyndrome\tO\n.\tO\n\nTNF\tO\nand\tO\nPAF\tO\nactivity\tO\nwas\tO\nfound\tO\nin\tO\nthe\tO\nserum\tO\nof\tO\nrespectively\tO\ntwo\tO\nand\tO\nfour\tO\nof\tO\nthe\tO\ncases\tO\n,\tO\nbut\tO\nnot\tO\nin\tO\nthe\tO\nsix\tO\ncontrols\tO\n.\tO\n\nAs\tO\nTNF\tO\nand\tO\nPAF\tO\nare\tO\nthought\tO\nto\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nseptic\tO\nshock\tB-Disease\nand\tO\nadult\tB-Disease\nrespiratory\tI-Disease\ndistress\tI-Disease\nsyndrome\tI-Disease\n,\tO\nwe\tO\nhypothesize\tO\nthat\tO\nhigh\tO\n-\tO\ndose\tO\nAra\tB-Chemical\n-\tI-Chemical\nC\tI-Chemical\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\ncytokine\tO\nrelease\tO\n.\tO\n\nProtective\tO\neffect\tO\nof\tO\nclentiazem\tB-Chemical\nagainst\tO\nepinephrine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\ninjury\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\neffects\tO\nof\tO\nclentiazem\tB-Chemical\n,\tO\na\tO\n1\tB-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\nbenzothiazepine\tI-Chemical\ncalcium\tB-Chemical\nantagonist\tO\n,\tO\non\tO\nepinephrine\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nWith\tO\n2\tO\n-\tO\nweek\tO\nchronic\tO\nepinephrine\tB-Chemical\ninfusion\tO\n,\tO\n16\tO\nof\tO\n30\tO\nrats\tO\ndied\tO\nwithin\tO\n4\tO\ndays\tO\n,\tO\nand\tO\nsevere\tO\nischemic\tB-Disease\nlesions\tI-Disease\nand\tO\nfibrosis\tB-Disease\nof\tO\nthe\tO\nleft\tO\nventricles\tO\nwere\tO\nobserved\tO\n.\tO\n\nIn\tO\nepinephrine\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n,\tO\nleft\tO\natrial\tO\nand\tO\nleft\tO\nventricular\tO\npapillary\tO\nmuscle\tO\ncontractile\tO\nresponses\tO\nto\tO\nisoproterenol\tB-Chemical\nwere\tO\nreduced\tO\n,\tO\nbut\tO\nresponses\tO\nto\tO\ncalcium\tB-Chemical\nwere\tO\nnormal\tO\nor\tO\nenhanced\tO\ncompared\tO\nto\tO\ncontrols\tO\n.\tO\n\nLeft\tO\nventricular\tO\nalpha\tO\nand\tO\nbeta\tO\nadrenoceptor\tO\ndensities\tO\nwere\tO\nalso\tO\nreduced\tO\ncompared\tO\nto\tO\ncontrols\tO\n.\tO\n\nTreatment\tO\nwith\tO\nclentiazem\tB-Chemical\nprevented\tO\nepinephrine\tB-Chemical\n-\tO\ninduced\tO\ndeath\tO\n(\tO\nP\tO\n<\tO\n.\tO\n05\tO\n)\tO\n,\tO\nand\tO\nattenuated\tO\nthe\tO\nventricular\tO\nischemic\tB-Disease\nlesions\tI-Disease\nand\tO\nfibrosis\tB-Disease\n,\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nLeft\tO\natrial\tO\nand\tO\nleft\tO\nventricular\tO\npapillary\tO\nmuscle\tO\ncontractile\tO\nresponses\tO\nto\tO\nisoproterenol\tB-Chemical\nwere\tO\nreduced\tO\ncompared\tO\nto\tO\ncontrols\tO\nin\tO\ngroups\tO\ntreated\tO\nwith\tO\nclentiazem\tB-Chemical\nalone\tO\n,\tO\nbut\tO\ncombined\tO\nwith\tO\nepinephrine\tB-Chemical\n,\tO\nclentiazem\tB-Chemical\nrestored\tO\nleft\tO\natrial\tO\nresponses\tO\nand\tO\nenhanced\tO\nleft\tO\nventricular\tO\npapillary\tO\nresponses\tO\nto\tO\nisoproterenol\tB-Chemical\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\nclentiazem\tB-Chemical\ndid\tO\nnot\tO\nprevent\tO\nepinephrine\tB-Chemical\n-\tO\ninduced\tO\ndown\tO\n-\tO\nregulation\tO\nof\tO\nalpha\tO\nand\tO\nbeta\tO\nadrenoceptors\tO\n.\tO\n\nInterestingly\tO\n,\tO\nclentiazem\tB-Chemical\n,\tO\ninfused\tO\nalone\tO\n,\tO\nresulted\tO\nin\tO\ndecreased\tO\nadrenergic\tO\nreceptor\tO\ndensities\tO\nin\tO\nthe\tO\nleft\tO\nventricle\tO\n.\tO\n\nClentiazem\tB-Chemical\nalso\tO\ndid\tO\nnot\tO\nprevent\tO\nthe\tO\nenhanced\tO\nresponses\tO\nto\tO\ncalcium\tB-Chemical\nseen\tO\nin\tO\nthe\tO\nepinephrine\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\n,\tO\nalthough\tO\nthe\tO\nhigh\tO\ndose\tO\nof\tO\nclentiazem\tB-Chemical\npartially\tO\nattenuated\tO\nthe\tO\nmaximal\tO\nresponse\tO\nto\tO\ncalcium\tB-Chemical\ncompared\tO\nto\tO\nepinephrine\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nclentiazem\tB-Chemical\nattenuated\tO\nepinephrine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\ninjury\tI-Disease\n,\tO\npossibly\tO\nthrough\tO\nits\tO\neffect\tO\non\tO\nthe\tO\nadrenergic\tO\npathway\tO\n.\tO\n\nKaliuretic\tO\neffect\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\ntreatment\tO\nin\tO\nparkinsonian\tB-Disease\npatients\tO\n.\tO\n\nHypokalemia\tB-Disease\n,\tO\nsometimes\tO\nsevere\tO\n,\tO\nwas\tO\nobserved\tO\nin\tO\nsome\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n-\tO\ntreated\tO\nparkinsonian\tB-Disease\npatients\tO\n.\tO\n\nThe\tO\ninfluence\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\non\tO\nthe\tO\nrenal\tO\nexcretion\tO\nof\tO\npotassium\tB-Chemical\nwas\tO\nstudied\tO\nin\tO\n3\tO\npatients\tO\nwith\tO\nhypokalemia\tB-Disease\nand\tO\nin\tO\n5\tO\nnormokalemic\tO\npatients\tO\nby\tO\ndetermination\tO\nof\tO\nrenal\tO\nplasma\tO\nflow\tO\n,\tO\nglomerular\tO\nfiltration\tO\nrate\tO\n,\tO\nplasma\tO\nconcentration\tO\nof\tO\npotassium\tB-Chemical\nand\tO\nsodium\tB-Chemical\nas\tO\nwell\tO\nas\tO\nurinary\tO\nexcretion\tO\nof\tO\npotassium\tB-Chemical\n,\tO\nsodium\tB-Chemical\nand\tO\naldosterone\tB-Chemical\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\nDopa\tI-Chemical\nintake\tO\nwas\tO\nfound\tO\nto\tO\ncause\tO\nan\tO\nincreased\tO\nexcretion\tO\nof\tO\npotassium\tB-Chemical\n,\tO\nand\tO\nsometimes\tO\nalso\tO\nof\tO\nsodium\tB-Chemical\n,\tO\nin\tO\nthe\tO\nhypokalemic\tO\nbut\tO\nnot\tO\nin\tO\nthe\tO\nnormokalemic\tO\npatients\tO\n.\tO\n\nThis\tO\neffect\tO\non\tO\nthe\tO\nrenal\tO\nfunction\tO\ncould\tO\nbe\tO\nprohibited\tO\nby\tO\nthe\tO\nadministration\tO\nof\tO\na\tO\nperipheral\tO\ndopa\tO\ndecarbodylase\tO\ninhibitor\tO\n.\tO\n\nIt\tO\nis\tO\nnot\tO\nknown\tO\nwhy\tO\nthis\tO\neffect\tO\noccurred\tO\nin\tO\nsome\tO\nindividuals\tO\nbut\tO\nnot\tO\nin\tO\nothers\tO\n,\tO\nbut\tO\nour\tO\nresults\tO\nindicate\tO\na\tO\ncorrelation\tO\nbetween\tO\naldosterone\tB-Chemical\nproduction\tO\nand\tO\nthis\tO\nrenal\tO\neffect\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n.\tO\n\nCocaine\tB-Chemical\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\ninduced\tO\nby\tO\ncocaine\tB-Chemical\n.\tO\n\nThe\tO\nischemia\tB-Disease\nprobably\tO\ninduced\tO\nby\tO\ncoronary\tB-Disease\nartery\tI-Disease\nspasm\tI-Disease\nwas\tO\nreversed\tO\nby\tO\nnitroglycerin\tB-Chemical\nand\tO\ncalcium\tB-Chemical\nblocking\tO\nagents\tO\n.\tO\n\nDoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nmonitored\tO\nby\tO\nECG\tO\nin\tO\nfreely\tO\nmoving\tO\nmice\tO\n.\tO\n\nA\tO\nnew\tO\nmodel\tO\nto\tO\ntest\tO\npotential\tO\nprotectors\tO\n.\tO\n\nIn\tO\nlaboratory\tO\nanimals\tO\n,\tO\nhistology\tO\nis\tO\nmost\tO\ncommonly\tO\nused\tO\nto\tO\nstudy\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nfor\tO\nmonitoring\tO\nduring\tO\ntreatment\tO\n,\tO\nlarge\tO\nnumbers\tO\nof\tO\nanimals\tO\nare\tO\nneeded\tO\n.\tO\n\nRecently\tO\nwe\tO\ndeveloped\tO\na\tO\nnew\tO\nmethod\tO\nto\tO\nmeasure\tO\nECG\tO\nvalues\tO\nin\tO\nfreely\tO\nmoving\tO\nmice\tO\nby\tO\ntelemetry\tO\n.\tO\n\nWith\tO\nthis\tO\nmodel\tO\nwe\tO\ninvestigated\tO\nthe\tO\neffect\tO\nof\tO\nchronic\tO\ndoxorubicin\tB-Chemical\nadministration\tO\non\tO\nthe\tO\nECG\tO\nof\tO\nfreely\tO\nmoving\tO\nBALB\tO\n/\tO\nc\tO\nmice\tO\nand\tO\nthe\tO\nefficacy\tO\nof\tO\nICRF\tB-Chemical\n-\tI-Chemical\n187\tI-Chemical\nas\tO\na\tO\nprotective\tO\nagent\tO\n.\tO\n\nThe\tO\nST\tO\ninterval\tO\nsignificantly\tO\nwidened\tO\nfrom\tO\n15\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n5\tO\nto\tO\n56\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n11\tO\n.\tO\n8\tO\nms\tO\nin\tO\nweek\tO\n10\tO\n(\tO\n7\tO\nweekly\tO\ndoses\tO\nof\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\ndoxorubicin\tB-Chemical\ngiven\tO\ni\tO\n.\tO\nv\tO\n.\tO\nplus\tO\n3\tO\nweeks\tO\nof\tO\nobservation\tO\n)\tO\n.\tO\n\nThe\tO\nECG\tO\nof\tO\nthe\tO\ncontrol\tO\nanimals\tO\ndid\tO\nnot\tO\nchange\tO\nduring\tO\nthe\tO\nentire\tO\nstudy\tO\n.\tO\n\nAfter\tO\nsacrifice\tO\nthe\tO\nhearts\tO\nof\tO\ndoxorubicin\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\nwere\tO\nenlarged\tO\nand\tO\nthe\tO\natria\tO\nwere\tO\nhypertrophic\tB-Disease\n.\tO\n\nAs\tO\nthis\tO\nschedule\tO\nexerted\tO\nmore\tO\ntoxicity\tB-Disease\nthan\tO\nneeded\tO\nto\tO\ninvestigate\tO\nprotective\tO\nagents\tO\n,\tO\nthe\tO\nprotection\tO\nof\tO\nICRF\tB-Chemical\n-\tI-Chemical\n187\tI-Chemical\nwas\tO\ndetermined\tO\nusing\tO\na\tO\ndose\tO\nschedule\tO\nwith\tO\nlower\tO\ngeneral\tO\ntoxicity\tB-Disease\n(\tO\n6\tO\nweekly\tO\ndoses\tO\nof\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\ndoxorubicin\tB-Chemical\ngiven\tO\ni\tO\n.\tO\nv\tO\n.\tO\nplus\tO\n2\tO\nweeks\tO\nof\tO\nobservation\tO\n)\tO\n.\tO\n\nOn\tO\nthis\tO\nschedule\tO\n,\tO\nthe\tO\nanimals\tO\n'\tO\nhearts\tO\nappeared\tO\nnormal\tO\nafter\tO\nsacrifice\tO\nand\tO\nICRF\tB-Chemical\n-\tI-Chemical\n187\tI-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\ngiven\tO\ni\tO\n.\tO\np\tO\n.\tO\n1\tO\nh\tO\nbefore\tO\ndoxorubicin\tB-Chemical\n)\tO\nprovided\tO\nalmost\tO\nfull\tO\nprotection\tO\n.\tO\n\nThese\tO\ndata\tO\nwere\tO\nconfirmed\tO\nby\tO\nhistology\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nthis\tO\nnew\tO\nmodel\tO\nis\tO\nvery\tO\nsensitive\tO\nand\tO\nenables\tO\nmonitoring\tO\nof\tO\nthe\tO\ndevelopment\tO\nof\tO\ncardiotoxicity\tB-Disease\nwith\tO\ntime\tO\n.\tO\n\nThese\tO\nfindings\tO\nresult\tO\nin\tO\na\tO\nmodel\tO\nthat\tO\nallows\tO\nthe\tO\ntesting\tO\nof\tO\nprotectors\tO\nagainst\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nas\tO\ndemonstrated\tO\nby\tO\nthe\tO\nprotection\tO\nprovided\tO\nby\tO\nICRF\tB-Chemical\n-\tI-Chemical\n187\tI-Chemical\n.\tO\n\nEpinephrine\tB-Chemical\ndysrhythmogenicity\tO\nis\tO\nnot\tO\nenhanced\tO\nby\tO\nsubtoxic\tO\nbupivacaine\tB-Chemical\nin\tO\ndogs\tO\n.\tO\n\nSince\tO\nbupivacaine\tB-Chemical\nand\tO\nepinephrine\tB-Chemical\nmay\tO\nboth\tO\nprecipitate\tO\ndysrhythmias\tB-Disease\n,\tO\ncirculating\tO\nbupivacaine\tB-Chemical\nduring\tO\nregional\tO\nanesthesia\tO\ncould\tO\npotentiate\tO\ndysrhythmogenic\tO\neffects\tO\nof\tO\nepinephrine\tB-Chemical\n.\tO\n\nWe\tO\ntherefore\tO\nexamined\tO\nwhether\tO\nbupivacaine\tB-Chemical\nalters\tO\nthe\tO\ndysrhythmogenicity\tO\nof\tO\nsubsequent\tO\nadministration\tO\nof\tO\nepinephrine\tB-Chemical\nin\tO\nconscious\tO\n,\tO\nhealthy\tO\ndogs\tO\nand\tO\nin\tO\nanesthetized\tO\ndogs\tO\nwith\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nForty\tO\n-\tO\none\tO\nconscious\tO\ndogs\tO\nreceived\tO\n10\tO\nmicrograms\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nmin\tO\n-\tO\n1\tO\nepinephrine\tB-Chemical\n.\tO\n\nSeventeen\tO\nanimals\tO\nresponded\tO\nwith\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n(\tO\nVT\tB-Disease\n)\tO\nwithin\tO\n3\tO\nmin\tO\n.\tO\n\nAfter\tO\n3\tO\nh\tO\n,\tO\nthese\tO\nresponders\tO\nrandomly\tO\nreceived\tO\n1\tO\nor\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nbupivacaine\tB-Chemical\nor\tO\nsaline\tO\nover\tO\n5\tO\nmin\tO\n,\tO\nfollowed\tO\nby\tO\n10\tO\nmicrograms\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nmin\tO\n-\tO\n1\tO\nepinephrine\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\nbupivacaine\tB-Chemical\ngroups\tO\n,\tO\nepinephrine\tB-Chemical\ncaused\tO\nfewer\tO\nprodysrhythmic\tO\neffects\tO\nthan\tO\nwithout\tO\nbupivacaine\tB-Chemical\n.\tO\n\nVT\tB-Disease\nappeared\tO\nin\tO\nfewer\tO\ndogs\tO\nand\tO\nat\tO\na\tO\nlater\tO\ntime\tO\n,\tO\nand\tO\nthere\tO\nwere\tO\nmore\tO\nsinoatrial\tO\nbeats\tO\nand\tO\nless\tO\nectopies\tO\n.\tO\n\nEpinephrine\tB-Chemical\nshortened\tO\nQT\tO\nless\tO\nafter\tO\nbupivacaine\tB-Chemical\nthan\tO\nin\tO\ncontrol\tO\nanimals\tO\n.\tO\n\nOne\tO\nday\tO\nafter\tO\nexperimental\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n,\tO\nsix\tO\nadditional\tO\nhalothane\tB-Chemical\n-\tO\nanesthetized\tO\ndogs\tO\nreceived\tO\n4\tO\nmicrograms\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nmin\tO\n-\tO\n1\tO\nepinephrine\tB-Chemical\nuntil\tO\nVT\tB-Disease\nappeared\tO\n.\tO\n\nAfter\tO\n45\tO\nmin\tO\n,\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\nbupivacaine\tB-Chemical\nwas\tO\ninjected\tO\nover\tO\n5\tO\nmin\tO\n,\tO\nagain\tO\nfollowed\tO\nby\tO\n4\tO\nmicrograms\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nmin\tO\n-\tO\n1\tO\nepinephrine\tB-Chemical\n.\tO\n\nIn\tO\nthese\tO\ndogs\tO\n,\tO\nthe\tO\nprodysrhythmic\tO\nresponse\tO\nto\tO\nepinephrine\tB-Chemical\nwas\tO\nalso\tO\nmitigated\tO\nby\tO\npreceding\tO\nbupivacaine\tB-Chemical\n.\tO\n\nBupivacaine\tB-Chemical\nantagonizes\tO\nepinephrine\tB-Chemical\ndysrhythmogenicity\tO\nin\tO\nconscious\tO\ndogs\tO\nsusceptible\tO\nto\tO\nVT\tB-Disease\nand\tO\nin\tO\nanesthetized\tO\ndogs\tO\nwith\tO\nspontaneous\tO\npostinfarct\tO\ndysrhythmias\tB-Disease\n.\tO\n\nThere\tO\nis\tO\nno\tO\nevidence\tO\nthat\tO\nsystemic\tO\nsubtoxic\tO\nbupivacaine\tB-Chemical\nadministration\tO\nenhances\tO\nthe\tO\ndysrhythmogenicity\tO\nof\tO\nsubsequent\tO\nepinephrine\tB-Chemical\n.\tO\n\nMilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\ninduced\tO\nby\tO\n1\tB-Chemical\n,\tI-Chemical\n25\tI-Chemical\n(\tI-Chemical\nOH\tI-Chemical\n)\tI-Chemical\n2D\tI-Chemical\nin\tO\na\tO\npatient\tO\nwith\tO\nhypoparathyroidism\tB-Disease\n.\tO\n\nMilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\nwas\tO\nfirst\tO\ndescribed\tO\n70\tO\nyears\tO\nago\tO\nin\tO\nthe\tO\ncontext\tO\nof\tO\nthe\tO\ntreatment\tO\nof\tO\npeptic\tB-Disease\nulcer\tI-Disease\ndisease\tI-Disease\nwith\tO\nlarge\tO\namounts\tO\nof\tO\ncalcium\tB-Chemical\nand\tO\nalkali\tB-Chemical\n.\tO\n\nAlthough\tO\nwith\tO\ncurrent\tO\nulcer\tB-Disease\ntherapy\tO\n(\tO\nH\tO\n-\tO\n2\tO\nblockers\tO\n,\tO\nomeprazole\tB-Chemical\n,\tO\nand\tO\nsucralfate\tB-Chemical\n)\tO\n,\tO\nthe\tO\nfrequency\tO\nof\tO\nmilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\nhas\tO\ndecreased\tO\nsignificantly\tO\n,\tO\nthe\tO\nclassic\tO\ntriad\tO\nof\tO\nhypercalcemia\tB-Disease\n,\tO\nalkalosis\tB-Disease\n,\tO\nand\tO\nrenal\tB-Disease\nimpairment\tI-Disease\nremains\tO\nthe\tO\nhallmark\tO\nof\tO\nthe\tO\nsyndrome\tO\n.\tO\n\nMilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\ncan\tO\npresent\tO\nserious\tO\nand\tO\noccasionally\tO\nlife\tO\n-\tO\nthreatening\tO\nillness\tO\nunless\tO\ndiagnosed\tO\nand\tO\ntreated\tO\nappropriately\tO\n.\tO\n\nThis\tO\narticle\tO\npresents\tO\na\tO\npatient\tO\nwith\tO\nhypoparathyroidism\tB-Disease\nwho\tO\nwas\tO\ntreated\tO\nwith\tO\ncalcium\tB-Chemical\ncarbonate\tI-Chemical\nand\tO\ncalcitriol\tB-Chemical\nresulting\tO\nin\tO\ntwo\tO\nadmissions\tO\nto\tO\nthe\tO\nhospital\tO\nfor\tO\nmilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nsuccessfully\tO\ntreated\tO\nwith\tO\nintravenous\tO\npamidronate\tB-Chemical\non\tO\nhis\tO\nfirst\tO\nadmission\tO\nand\tO\nwith\tO\nhydrocortisone\tB-Chemical\non\tO\nthe\tO\nsecond\tO\n.\tO\n\nThis\tO\nillustrates\tO\nintravenous\tO\npamidronate\tB-Chemical\nas\tO\na\tO\nvaluable\tO\ntherapeutic\tO\ntool\tO\nwhen\tO\nmilk\tB-Disease\n-\tI-Disease\nalkali\tI-Disease\nsyndrome\tI-Disease\npresents\tO\nas\tO\nhypercalcemic\tB-Disease\nemergency\tI-Disease\n.\tO\n\nFamotidine\tB-Chemical\n-\tO\nassociated\tO\ndelirium\tB-Disease\n.\tO\n\nA\tO\nseries\tO\nof\tO\nsix\tO\ncases\tO\n.\tO\n\nFamotidine\tB-Chemical\nis\tO\na\tO\nhistamine\tO\nH2\tO\n-\tO\nreceptor\tO\nantagonist\tO\nused\tO\nin\tO\ninpatient\tO\nsettings\tO\nfor\tO\nprevention\tO\nof\tO\nstress\tO\nulcers\tB-Disease\nand\tO\nis\tO\nshowing\tO\nincreasing\tO\npopularity\tO\nbecause\tO\nof\tO\nits\tO\nlow\tO\ncost\tO\n.\tO\n\nAlthough\tO\nall\tO\nof\tO\nthe\tO\ncurrently\tO\navailable\tO\nH2\tO\n-\tO\nreceptor\tO\nantagonists\tO\nhave\tO\nshown\tO\nthe\tO\npropensity\tO\nto\tO\ncause\tO\ndelirium\tB-Disease\n,\tO\nonly\tO\ntwo\tO\npreviously\tO\nreported\tO\ncases\tO\nhave\tO\nbeen\tO\nassociated\tO\nwith\tO\nfamotidine\tB-Chemical\n.\tO\n\nThe\tO\nauthors\tO\nreport\tO\non\tO\nsix\tO\ncases\tO\nof\tO\nfamotidine\tB-Chemical\n-\tO\nassociated\tO\ndelirium\tB-Disease\nin\tO\nhospitalized\tO\npatients\tO\nwho\tO\ncleared\tO\ncompletely\tO\nupon\tO\nremoval\tO\nof\tO\nfamotidine\tB-Chemical\n.\tO\n\nThe\tO\npharmacokinetics\tO\nof\tO\nfamotidine\tB-Chemical\nare\tO\nreviewed\tO\n,\tO\nwith\tO\nno\tO\nchange\tO\nin\tO\nits\tO\nmetabolism\tO\nin\tO\nthe\tO\nelderly\tO\npopulation\tO\nseen\tO\n.\tO\n\nThe\tO\nimplications\tO\nof\tO\nusing\tO\nfamotidine\tB-Chemical\nin\tO\nelderly\tO\npersons\tO\nare\tO\ndiscussed\tO\n.\tO\n\nEncephalopathy\tB-Disease\nduring\tO\namitriptyline\tB-Chemical\ntherapy\tO\n:\tO\nare\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nand\tO\nserotonin\tB-Disease\nsyndrome\tI-Disease\nspectrum\tO\ndisorders\tO\n?\tO\n\nThis\tO\nreport\tO\ndescribes\tO\na\tO\ncase\tO\nof\tO\nencephalopathy\tB-Disease\ndeveloped\tO\nin\tO\nthe\tO\ncourse\tO\nof\tO\namitriptyline\tB-Chemical\ntherapy\tO\n,\tO\nduring\tO\na\tO\nremission\tO\nof\tO\nunipolar\tB-Disease\ndepression\tI-Disease\n.\tO\n\nThis\tO\npatient\tO\ncould\tO\nhave\tO\nbeen\tO\ndiagnosed\tO\nas\tO\nhaving\tO\neither\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\n(\tO\nNMS\tB-Disease\n)\tO\nor\tO\nserotonin\tB-Disease\nsyndrome\tI-Disease\n(\tO\nSS\tB-Disease\n)\tO\n.\tO\n\nThe\tO\nmajor\tO\ndeterminant\tO\nof\tO\nthe\tO\nsymptoms\tO\nmay\tO\nhave\tO\nbeen\tO\ndopamine\tB-Chemical\n/\tO\nserotonin\tB-Chemical\nimbalance\tO\nin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nThe\tO\nNMS\tB-Disease\n-\tO\nlike\tO\nencephalopathy\tB-Disease\nthat\tO\ndevelops\tO\nin\tO\nassociation\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nantidepressants\tO\nindicates\tO\nthat\tO\nNMS\tB-Disease\nand\tO\nSS\tB-Disease\nare\tO\nspectrum\tO\ndisorders\tO\ninduced\tO\nby\tO\ndrugs\tO\nwith\tO\nboth\tO\nantidopaminergic\tO\nand\tO\nserotonergic\tO\neffects\tO\n.\tO\n\nGenetic\tO\nseparation\tO\nof\tO\ntumor\tB-Disease\ngrowth\tO\nand\tO\nhemorrhagic\tB-Disease\nphenotypes\tO\nin\tO\nan\tO\nestrogen\tB-Chemical\n-\tO\ninduced\tO\ntumor\tB-Disease\n.\tO\n\nChronic\tO\nadministration\tO\nof\tO\nestrogen\tB-Chemical\nto\tO\nthe\tO\nFischer\tO\n344\tO\n(\tO\nF344\tO\n)\tO\nrat\tO\ninduces\tO\ngrowth\tO\nof\tO\nlarge\tO\n,\tO\nhemorrhagic\tB-Disease\npituitary\tB-Disease\ntumors\tI-Disease\n.\tO\n\nTen\tO\nweeks\tO\nof\tO\ndiethylstilbestrol\tB-Chemical\n(\tO\nDES\tB-Chemical\n)\tO\ntreatment\tO\ncaused\tO\nfemale\tO\nF344\tO\nrat\tO\npituitaries\tO\nto\tO\ngrow\tO\nto\tO\nan\tO\naverage\tO\nof\tO\n109\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n3\tO\nmg\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\nversus\tO\n11\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n4\tO\nmg\tO\nfor\tO\nuntreated\tO\nrats\tO\n,\tO\nand\tO\nto\tO\nbecome\tO\nhighly\tO\nhemorrhagic\tB-Disease\n.\tO\n\nThe\tO\nsame\tO\nDES\tB-Chemical\ntreatment\tO\nproduced\tO\nno\tO\nsignificant\tO\ngrowth\tO\n(\tO\n8\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n5\tO\nmg\tO\nfor\tO\ntreated\tO\nfemales\tO\nversus\tO\n8\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n1\tO\nfor\tO\nuntreated\tO\nfemales\tO\n)\tO\nor\tO\nmorphological\tO\nchanges\tO\nin\tO\nBrown\tO\nNorway\tO\n(\tO\nBN\tO\n)\tO\nrat\tO\npituitaries\tO\n.\tO\n\nAn\tO\nF1\tO\nhybrid\tO\nof\tO\nF344\tO\nand\tO\nBN\tO\nexhibited\tO\nsignificant\tO\npituitary\tO\ngrowth\tO\nafter\tO\n10\tO\nweeks\tO\nof\tO\nDES\tB-Chemical\ntreatment\tO\nwith\tO\nan\tO\naverage\tO\nmass\tO\nof\tO\n26\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\nmg\tO\ncompared\tO\nwith\tO\n8\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n9\tO\nmg\tO\nfor\tO\nuntreated\tO\nrats\tO\n.\tO\n\nSurprisingly\tO\n,\tO\nthe\tO\nF1\tO\nhybrid\tO\ntumors\tB-Disease\nwere\tO\nnot\tO\nhemorrhagic\tB-Disease\nand\tO\nhad\tO\nhemoglobin\tO\ncontent\tO\nand\tO\noutward\tO\nappearance\tO\nidentical\tO\nto\tO\nthat\tO\nof\tO\nBN\tO\n.\tO\n\nExpression\tO\nof\tO\nboth\tO\ngrowth\tO\nand\tO\nmorphological\tO\nchanges\tO\nis\tO\ndue\tO\nto\tO\nmultiple\tO\ngenes\tO\n.\tO\n\nHowever\tO\n,\tO\nwhile\tO\nDES\tB-Chemical\n-\tO\ninduced\tO\npituitary\tO\ngrowth\tO\nexhibited\tO\nquantitative\tO\n,\tO\nadditive\tO\ninheritance\tO\n,\tO\nthe\tO\nhemorrhagic\tB-Disease\nphenotype\tO\nexhibited\tO\nrecessive\tO\n,\tO\nepistatic\tO\ninheritance\tO\n.\tO\n\nOnly\tO\n5\tO\nof\tO\nthe\tO\n160\tO\nF2\tO\npituitaries\tO\nexhibited\tO\nthe\tO\nhemorrhagic\tB-Disease\nphenotype\tO\n;\tO\n36\tO\nof\tO\nthe\tO\n160\tO\nF2\tO\npituitaries\tO\nwere\tO\nin\tO\nthe\tO\nF344\tO\nrange\tO\nof\tO\nmass\tO\n,\tO\nbut\tO\n31\tO\nof\tO\nthese\tO\nwere\tO\nnot\tO\nhemorrhagic\tB-Disease\n,\tO\nindicating\tO\nthat\tO\nthe\tO\nhemorrhagic\tB-Disease\nphenotype\tO\nis\tO\nnot\tO\nmerely\tO\na\tO\nconsequence\tO\nof\tO\nextensive\tO\ngrowth\tO\n.\tO\n\nThe\tO\nhemorrhagic\tB-Disease\nF2\tO\npituitaries\tO\nwere\tO\nall\tO\namong\tO\nthe\tO\nmost\tO\nmassive\tO\n,\tO\nindicating\tO\nthat\tO\nsome\tO\nof\tO\nthe\tO\ngenes\tO\nregulate\tO\nboth\tO\nphenotypes\tO\n.\tO\n\nIncreased\tO\nexpression\tO\nof\tO\nneuronal\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsynthase\tO\nin\tO\nbladder\tO\nafferent\tO\npathways\tO\nfollowing\tO\nchronic\tO\nbladder\tB-Disease\nirritation\tI-Disease\n.\tO\n\nImmunocytochemical\tO\ntechniques\tO\nwere\tO\nused\tO\nto\tO\nexamine\tO\nalterations\tO\nin\tO\nthe\tO\nexpression\tO\nof\tO\nneuronal\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsynthase\tO\n(\tO\nNOS\tO\n)\tO\nin\tO\nbladder\tO\npathways\tO\nfollowing\tO\nacute\tO\nand\tO\nchronic\tO\nirritation\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nurinary\tI-Disease\ntract\tI-Disease\nof\tO\nthe\tO\nrat\tO\n.\tO\n\nChemical\tO\ncystitis\tB-Disease\nwas\tO\ninduced\tO\nby\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCYP\tB-Chemical\n)\tO\nwhich\tO\nis\tO\nmetabolized\tO\nto\tO\nacrolein\tB-Chemical\n,\tO\nan\tO\nirritant\tO\neliminated\tO\nin\tO\nthe\tO\nurine\tO\n.\tO\n\nInjection\tO\nof\tO\nCYP\tB-Chemical\n(\tO\nn\tO\n=\tO\n10\tO\n,\tO\n75\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n2\tO\nhours\tO\nprior\tO\nto\tO\nperfusion\tO\n(\tO\nacute\tO\ntreatment\tO\n)\tO\nof\tO\nthe\tO\nanimals\tO\nincreased\tO\nFos\tO\n-\tO\nimmunoreactivity\tO\n(\tO\nIR\tO\n)\tO\nin\tO\nneurons\tO\nin\tO\nthe\tO\ndorsal\tO\ncommissure\tO\n,\tO\ndorsal\tO\nhorn\tO\n,\tO\nand\tO\nautonomic\tO\nregions\tO\nof\tO\nspinal\tO\nsegments\tO\n(\tO\nL1\tO\n-\tO\nL2\tO\nand\tO\nL6\tO\n-\tO\nS1\tO\n)\tO\nwhich\tO\nreceive\tO\nafferent\tO\ninputs\tO\nfrom\tO\nthe\tO\nbladder\tO\n,\tO\nurethra\tO\n,\tO\nand\tO\nureter\tO\n.\tO\n\nFos\tO\n-\tO\nIR\tO\nin\tO\nthe\tO\nspinal\tO\ncord\tO\nwas\tO\nnot\tO\nchanged\tO\nin\tO\nrats\tO\nreceiving\tO\nchronic\tO\nCYP\tB-Chemical\ntreatment\tO\n(\tO\nn\tO\n=\tO\n15\tO\n,\tO\n75\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\nevery\tO\n3rd\tO\nday\tO\nfor\tO\n2\tO\nweeks\tO\n)\tO\n.\tO\n\nIn\tO\ncontrol\tO\nanimals\tO\nand\tO\nin\tO\nanimals\tO\ntreated\tO\nacutely\tO\nwith\tO\nCYP\tB-Chemical\n,\tO\nonly\tO\nsmall\tO\nnumbers\tO\nof\tO\nNOS\tO\n-\tO\nIR\tO\ncells\tO\n(\tO\n0\tO\n.\tO\n5\tO\n-\tO\n0\tO\n.\tO\n7\tO\ncell\tO\nprofiles\tO\n/\tO\nsections\tO\n)\tO\nwere\tO\ndetected\tO\nin\tO\nthe\tO\nL6\tO\n-\tO\nS1\tO\ndorsal\tO\nroot\tO\nganglia\tO\n(\tO\nDRG\tO\n)\tO\n.\tO\n\nChronic\tO\nCYP\tB-Chemical\nadministration\tO\nsignificantly\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n.\tO\n002\tO\n)\tO\nincreased\tO\nbladder\tO\nweight\tO\nby\tO\n60\tO\n%\tO\nand\tO\nincreased\tO\n(\tO\n7\tO\n-\tO\nto\tO\n11\tO\n-\tO\nfold\tO\n)\tO\nthe\tO\nnumbers\tO\nof\tO\nNOS\tO\n-\tO\nimmunoreactive\tO\n(\tO\nIR\tO\n)\tO\nafferent\tO\nneurons\tO\nin\tO\nthe\tO\nL6\tO\n-\tO\nS1\tO\nDRG\tO\n.\tO\n\nA\tO\nsmall\tO\nincrease\tO\n(\tO\n1\tO\n.\tO\n5\tO\n-\tO\nfold\tO\n)\tO\nalso\tO\noccurred\tO\nin\tO\nthe\tO\nL1\tO\nDRG\tO\n,\tO\nbut\tO\nno\tO\nchange\tO\nwas\tO\ndetected\tO\nin\tO\nthe\tO\nL2\tO\nand\tO\nL5\tO\nDRG\tO\n.\tO\n\nBladder\tO\nafferent\tO\ncells\tO\nin\tO\nthe\tO\nL6\tO\n-\tO\nS1\tO\nDRG\tO\nlabeled\tO\nby\tO\nFluorogold\tO\n(\tO\n40\tO\nmicroliters\tO\n)\tO\ninjected\tO\ninto\tO\nthe\tO\nbladder\tO\nwall\tO\ndid\tO\nnot\tO\nexhibit\tO\nNOS\tO\n-\tO\nIR\tO\nin\tO\ncontrol\tO\nanimals\tO\n;\tO\nhowever\tO\n,\tO\nfollowing\tO\nchronic\tO\nCYP\tB-Chemical\nadministration\tO\n,\tO\na\tO\nsignificant\tO\npercentage\tO\nof\tO\nbladder\tO\nafferent\tO\nneurons\tO\nwere\tO\nNOS\tO\n-\tO\nIR\tO\n:\tO\nL6\tO\n(\tO\n19\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n6\tO\n%\tO\n)\tO\nand\tO\nS1\tO\n(\tO\n25\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n9\tO\n%\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nneuronal\tO\ngene\tO\nexpression\tO\nin\tO\nvisceral\tO\nsensory\tO\npathways\tO\ncan\tO\nbe\tO\nupregulated\tO\nby\tO\nchemical\tO\nirritation\tO\nof\tO\nafferent\tO\nreceptors\tO\nin\tO\nthe\tO\nurinary\tO\ntract\tO\nand\tO\n/\tO\nor\tO\nthat\tO\npathological\tO\nchanges\tO\nin\tO\nthe\tO\nurinary\tO\ntract\tO\ncan\tO\ninitiate\tO\nchemical\tO\nsignals\tO\nthat\tO\nalter\tO\nthe\tO\nchemical\tO\nproperties\tO\nof\tO\nvisceral\tO\nafferent\tO\nneurons\tO\n.\tO\n\nEffects\tO\nof\tO\na\tO\nnew\tO\ncalcium\tB-Chemical\nantagonist\tO\n,\tO\nCD\tB-Chemical\n-\tI-Chemical\n832\tI-Chemical\n,\tO\non\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\nin\tO\ndogs\tO\nwith\tO\npartial\tO\ncoronary\tB-Disease\nstenosis\tI-Disease\n.\tO\n\nEffects\tO\nof\tO\nCD\tB-Chemical\n-\tI-Chemical\n832\tI-Chemical\non\tO\nisoproterenol\tB-Chemical\n(\tO\nISO\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\nwere\tO\nstudied\tO\nin\tO\ndogs\tO\nwith\tO\npartial\tO\ncoronary\tB-Disease\nstenosis\tI-Disease\nof\tO\nthe\tO\nleft\tO\ncircumflex\tO\ncoronary\tO\nartery\tO\nand\tO\nfindings\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nfor\tO\nnifedipine\tB-Chemical\nor\tO\ndiltiazem\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\npresence\tO\nof\tO\ncoronary\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\n,\tO\n3\tO\n-\tO\nmin\tO\nperiods\tO\nof\tO\nintracoronary\tO\nISO\tB-Chemical\ninfusion\tO\n(\tO\n10\tO\nng\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n)\tO\nincreased\tO\nheart\tO\nrate\tO\nand\tO\nmaximal\tO\nrate\tO\nof\tO\nleft\tO\nventricular\tO\npressure\tO\nrise\tO\n,\tO\nwhich\tO\nresulted\tO\nin\tO\na\tO\ndecrease\tO\nin\tO\npercentage\tO\nsegmental\tO\nshortening\tO\nand\tO\nST\tO\n-\tO\nsegment\tO\nelevation\tO\nof\tO\nthe\tO\nepicardial\tO\nelectrocardiogram\tO\n.\tO\n\nAfter\tO\nthe\tO\ncontrol\tO\nISO\tB-Chemical\ninfusion\tO\nwith\tO\nstenosis\tB-Disease\nwas\tO\nperformed\tO\n,\tO\nequihypotensive\tO\ndoses\tO\nof\tO\nCD\tB-Chemical\n-\tI-Chemical\n832\tI-Chemical\n(\tO\n3\tO\nand\tO\n10\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n,\tO\nn\tO\n=\tO\n7\tO\n)\tO\n,\tO\nnifedipine\tB-Chemical\n(\tO\n1\tO\nand\tO\n3\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n,\tO\nn\tO\n=\tO\n9\tO\n)\tO\nor\tO\ndiltiazem\tB-Chemical\n(\tO\n10\tO\nand\tO\n30\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n,\tO\nn\tO\n=\tO\n7\tO\n)\tO\nwere\tO\ninfused\tO\n5\tO\nmin\tO\nbefore\tO\nand\tO\nduring\tO\nthe\tO\nsecond\tO\nand\tO\nthird\tO\nISO\tB-Chemical\ninfusion\tO\n.\tO\n\nBoth\tO\nCD\tB-Chemical\n-\tI-Chemical\n832\tI-Chemical\nand\tO\ndiltiazem\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nnifedipine\tB-Chemical\n,\tO\nsignificantly\tO\nreduced\tO\nthe\tO\nincrease\tO\nin\tO\nheart\tO\nrate\tO\ninduced\tO\nby\tO\nISO\tB-Chemical\ninfusion\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\nnifedipine\tB-Chemical\n,\tO\nCD\tB-Chemical\n-\tI-Chemical\n832\tI-Chemical\n(\tO\n10\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n)\tO\nprevented\tO\nthe\tO\ndecrease\tO\nin\tO\npercentage\tO\nsegmental\tO\nshortening\tO\nfrom\tO\n32\tO\n+\tO\n/\tO\n-\tO\n12\tO\n%\tO\nto\tO\n115\tO\n+\tO\n/\tO\n-\tO\n26\tO\n%\tO\nof\tO\nthe\tO\ncontrol\tO\nvalue\tO\n(\tO\nP\tO\n<\tO\n.\tO\n01\tO\n)\tO\nand\tO\nST\tO\n-\tO\nsegment\tO\nelevation\tO\nfrom\tO\n5\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n0\tO\nmV\tO\nto\tO\n1\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n3\tO\nmV\tO\n(\tO\nP\tO\n<\tO\n.\tO\n01\tO\n)\tO\nat\tO\n3\tO\nmin\tO\nafter\tO\nISO\tB-Chemical\ninfusion\tO\nwith\tO\nstenosis\tB-Disease\n.\tO\n\nDiltiazem\tB-Chemical\n(\tO\n30\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n)\tO\nalso\tO\nprevented\tO\nthe\tO\ndecrease\tO\nin\tO\npercentage\tO\nsegmental\tO\nshortening\tO\nfrom\tO\n34\tO\n+\tO\n/\tO\n-\tO\n14\tO\n%\tO\nto\tO\n63\tO\n+\tO\n/\tO\n-\tO\n18\tO\n%\tO\nof\tO\nthe\tO\ncontrol\tO\nvalue\tO\n(\tO\nP\tO\n<\tO\n.\tO\n05\tO\n)\tO\nand\tO\nST\tO\n-\tO\nsegment\tO\nelevation\tO\nfrom\tO\n4\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\nmV\tO\nto\tO\n2\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\nmV\tO\n(\tO\nP\tO\n<\tO\n.\tO\n01\tO\n)\tO\nat\tO\n3\tO\nmin\tO\nafter\tO\nISO\tB-Chemical\ninfusion\tO\nwith\tO\nstenosis\tB-Disease\n.\tO\n\nThese\tO\ndata\tO\nshow\tO\nthat\tO\nCD\tB-Chemical\n-\tI-Chemical\n832\tI-Chemical\nimproves\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\nduring\tO\nISO\tB-Chemical\ninfusion\tO\nwith\tO\nstenosis\tB-Disease\nand\tO\nsuggest\tO\nthat\tO\nthe\tO\nnegative\tO\nchronotropic\tO\nproperty\tO\nof\tO\nCD\tB-Chemical\n-\tI-Chemical\n832\tI-Chemical\nplays\tO\na\tO\nmajor\tO\nrole\tO\nin\tO\nthe\tO\nbeneficial\tO\neffects\tO\nof\tO\nCD\tB-Chemical\n-\tI-Chemical\n832\tI-Chemical\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nrecombinant\tO\nhuman\tO\ninsulin\tO\n-\tO\nlike\tO\ngrowth\tO\nfactor\tO\n-\tO\nI\tO\non\tO\nchronic\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nnephropathy\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nWe\tO\nrecently\tO\ndemonstrated\tO\nthat\tO\nrecombinant\tO\nhGH\tO\nexacerbates\tO\nrenal\tO\nfunctional\tO\nand\tO\nstructural\tO\ninjury\tO\nin\tO\nchronic\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n)\tO\nnephropathy\tB-Disease\n,\tO\nan\tO\nexperimental\tO\nmodel\tO\nof\tO\nglomerular\tB-Disease\ndisease\tI-Disease\n.\tO\n\nTherefore\tO\n,\tO\nwe\tO\nexamined\tO\nwhether\tO\nrecombinant\tO\nhuman\tO\n(\tO\nrh\tO\n)\tO\nIGF\tO\n-\tO\nI\tO\nis\tO\na\tO\nsafer\tO\nalternative\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\ngrowth\tB-Disease\nfailure\tI-Disease\nin\tO\nrats\tO\nwith\tO\nchronic\tO\nPAN\tB-Chemical\nnephropathy\tB-Disease\n.\tO\n\nThe\tO\nglomerulopathy\tB-Disease\nwas\tO\ninduced\tO\nby\tO\nseven\tO\nserial\tO\ninjections\tO\nof\tO\nPAN\tB-Chemical\nover\tO\n12\tO\nwk\tO\n.\tO\n\nExperimental\tO\nanimals\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nreceived\tO\nrhIGF\tO\n-\tO\nI\tO\n,\tO\n400\tO\nmicrograms\tO\n/\tO\nd\tO\n,\tO\nwhereas\tO\ncontrol\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nreceived\tO\nthe\tO\nvehicle\tO\n.\tO\n\nrhIGF\tO\n-\tO\nI\tO\nimproved\tO\nweight\tO\ngain\tO\nby\tO\n14\tO\n%\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nwithout\tO\naltering\tO\nhematocrit\tO\nor\tO\nblood\tO\npressure\tO\nin\tO\nrats\tO\nwith\tO\nrenal\tB-Disease\ndisease\tI-Disease\n.\tO\n\nUrinary\tO\nprotein\tO\nexcretion\tO\nwas\tO\nunaltered\tO\nby\tO\nrhIGF\tO\n-\tO\nI\tO\ntreatment\tO\nin\tO\nrats\tO\nwith\tO\nchronic\tO\nPAN\tB-Chemical\nnephropathy\tB-Disease\n.\tO\n\nAfter\tO\n12\tO\nwk\tO\n,\tO\nthe\tO\ninulin\tO\nclearance\tO\nwas\tO\nhigher\tO\nin\tO\nrhIGF\tO\n-\tO\nI\tO\n-\tO\ntreated\tO\nrats\tO\n,\tO\n0\tO\n.\tO\n48\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n08\tO\nversus\tO\n0\tO\n.\tO\n24\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n06\tO\nmL\tO\n/\tO\nmin\tO\n/\tO\n100\tO\ng\tO\nof\tO\nbody\tO\nweight\tO\nin\tO\nuntreated\tO\nPAN\tB-Chemical\nnephropathy\tB-Disease\nanimals\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n.\tO\n\nThe\tO\nimprovement\tO\nin\tO\nGFR\tO\nwas\tO\nnot\tO\nassociated\tO\nwith\tO\nenhanced\tO\nglomerular\tB-Disease\nhypertrophy\tI-Disease\nor\tO\nincreased\tO\nsegmental\tO\nglomerulosclerosis\tB-Disease\n,\tO\ntubulointerstitial\tB-Disease\ninjury\tI-Disease\n,\tO\nor\tO\nrenal\tO\ncortical\tO\nmalondialdehyde\tB-Chemical\ncontent\tO\n.\tO\n\nIn\tO\nrats\tO\nwith\tO\nPAN\tB-Chemical\nnephropathy\tB-Disease\n,\tO\nadministration\tO\nof\tO\nrhIGF\tO\n-\tO\nI\tO\nincreased\tO\nIGF\tO\n-\tO\nI\tO\nand\tO\nGH\tO\nreceptor\tO\ngene\tO\nexpression\tO\n,\tO\nwithout\tO\naltering\tO\nthe\tO\nsteady\tO\nstate\tO\nlevel\tO\nof\tO\nIGF\tO\n-\tO\nI\tO\nreceptor\tO\nmRNA\tO\n.\tO\n\nIn\tO\nnormal\tO\nrats\tO\nwith\tO\nintact\tO\nkidneys\tO\n,\tO\nrhIGF\tO\n-\tO\nI\tO\nadministration\tO\n(\tO\nn\tO\n=\tO\n4\tO\n)\tO\ndid\tO\nnot\tO\nalter\tO\nweight\tO\ngain\tO\n,\tO\nblood\tO\npressure\tO\n,\tO\nproteinuria\tB-Disease\n,\tO\nGFR\tO\n,\tO\nglomerular\tO\nplanar\tO\narea\tO\n,\tO\nrenal\tO\ncortical\tO\nmalondialdehyde\tB-Chemical\ncontent\tO\n,\tO\nor\tO\nglomerular\tO\nor\tO\ntubulointerstitial\tB-Disease\ndamage\tI-Disease\n,\tO\ncompared\tO\nwith\tO\nuntreated\tO\nanimals\tO\n(\tO\nn\tO\n=\tO\n4\tO\n)\tO\n.\tO\n\nrhIGF\tO\n-\tO\nI\tO\ntreatment\tO\nreduced\tO\nthe\tO\nsteady\tO\nstate\tO\nrenal\tO\nIGF\tO\n-\tO\nI\tO\nmRNA\tO\nlevel\tO\nbut\tO\ndid\tO\nnot\tO\nmodify\tO\ngene\tO\nexpression\tO\nof\tO\nthe\tO\nIGF\tO\n-\tO\nI\tO\nor\tO\nGH\tO\nreceptors\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\n:\tO\n1\tO\n)\tO\nadministration\tO\nof\tO\nrhIGF\tO\n-\tO\nI\tO\nimproves\tO\ngrowth\tO\nand\tO\nGFR\tO\nin\tO\nrats\tO\nwith\tO\nchronic\tO\nPAN\tB-Chemical\nnephropathy\tB-Disease\nand\tO\n2\tO\n)\tO\nunlike\tO\nrhGH\tO\n,\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nrhIGF\tO\n-\tO\nI\tO\ndoes\tO\nnot\tO\nworsen\tO\nrenal\tO\nfunctional\tO\nand\tO\nstructural\tO\ninjury\tO\nin\tO\nthis\tO\ndisease\tO\nmodel\tO\n.\tO\n\nNefiracetam\tB-Chemical\n(\tO\nDM\tB-Chemical\n-\tI-Chemical\n9384\tI-Chemical\n)\tO\nreverses\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\nof\tO\na\tO\npassive\tO\navoidance\tO\nresponse\tO\n:\tO\ndelayed\tO\nemergence\tO\nof\tO\nthe\tO\nmemory\tO\nretention\tO\neffects\tO\n.\tO\n\nNefiracetam\tB-Chemical\nis\tO\na\tO\nnovel\tO\npyrrolidone\tB-Chemical\nderivative\tO\nwhich\tO\nattenuates\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\nlearning\tB-Disease\nand\tI-Disease\npost\tI-Disease\n-\tI-Disease\ntraining\tI-Disease\nconsolidation\tI-Disease\ndeficits\tI-Disease\n.\tO\n\nGiven\tO\nthat\tO\napomorphine\tB-Chemical\ninhibits\tO\npassive\tO\navoidance\tO\nretention\tO\nwhen\tO\ngiven\tO\nduring\tO\ntraining\tO\nor\tO\nin\tO\na\tO\ndefined\tO\n10\tO\n-\tO\n12h\tO\npost\tO\n-\tO\ntraining\tO\nperiod\tO\n,\tO\nwe\tO\nevaluated\tO\nthe\tO\nability\tO\nof\tO\nnefiracetam\tB-Chemical\nto\tO\nattenuate\tO\namnesia\tB-Disease\ninduced\tO\nby\tO\ndopaminergic\tO\nagonism\tO\n.\tO\n\nA\tO\nstep\tO\n-\tO\ndown\tO\npassive\tO\navoidance\tO\nparadigm\tO\nwas\tO\nemployed\tO\nand\tO\nnefiracetam\tB-Chemical\n(\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\napomorphine\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwere\tO\ngiven\tO\nalone\tO\nor\tO\nin\tO\ncombination\tO\nduring\tO\ntraining\tO\nand\tO\nat\tO\nthe\tO\n10\tO\n-\tO\n12h\tO\npost\tO\n-\tO\ntraining\tO\nperiod\tO\nof\tO\nconsolidation\tO\n.\tO\n\nCo\tO\n-\tO\nadministration\tO\nof\tO\nnefiracetam\tB-Chemical\nand\tO\napomorphine\tB-Chemical\nduring\tO\ntraining\tO\nor\tO\n10h\tO\nthereafter\tO\nproduced\tO\nno\tO\nsignificant\tO\nanti\tO\n-\tO\namnesic\tO\neffect\tO\n.\tO\n\nHowever\tO\n,\tO\nadministration\tO\nof\tO\nnefiracetam\tB-Chemical\nduring\tO\ntraining\tO\ncompletely\tO\nreversed\tO\nthe\tO\namnesia\tB-Disease\ninduced\tO\nby\tO\napomorphine\tB-Chemical\nat\tO\nthe\tO\n10h\tO\npost\tO\n-\tO\ntraining\tO\ntime\tO\nand\tO\nthe\tO\nconverse\tO\nwas\tO\nalso\tO\ntrue\tO\n.\tO\n\nThese\tO\neffects\tO\nwere\tO\nnot\tO\nmediated\tO\nby\tO\na\tO\ndopaminergic\tO\nmechanism\tO\nas\tO\nnefiracetam\tB-Chemical\n,\tO\nat\tO\nmillimolar\tO\nconcentrations\tO\n,\tO\nfailed\tO\nto\tO\ndisplace\tO\neither\tO\n[\tO\n3H\tO\n]\tO\nSCH\tB-Chemical\n23390\tI-Chemical\nor\tO\n[\tO\n3H\tO\n]\tO\nspiperone\tB-Chemical\nbinding\tO\nfrom\tO\nD1\tO\nor\tO\nD2\tO\ndopamine\tB-Chemical\nreceptor\tO\nsubtypes\tO\n,\tO\nrespectively\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\nnefiracetam\tB-Chemical\naugments\tO\nmolecular\tO\nprocesses\tO\nin\tO\nthe\tO\nearly\tO\nstages\tO\nof\tO\nevents\tO\nwhich\tO\nultimately\tO\nlead\tO\nto\tO\nconsolidation\tO\nof\tO\nmemory\tO\n.\tO\n\nPhenytoin\tB-Chemical\nencephalopathy\tB-Disease\nas\tO\nprobable\tO\nidiosyncratic\tO\nreaction\tO\n:\tO\ncase\tO\nreport\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nphenytoin\tB-Chemical\n(\tO\nDPH\tB-Chemical\n)\tO\nencephalopathy\tB-Disease\nwith\tO\nincreasing\tO\nseizures\tB-Disease\nand\tO\nEEG\tO\nand\tO\nmental\tO\nchanges\tO\nis\tO\ndescribed\tO\n.\tO\n\nDespite\tO\nadequate\tO\noral\tO\ndosage\tO\nof\tO\nDPH\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\ndaily\tO\n)\tO\nthe\tO\nplasma\tO\nlevel\tO\nwas\tO\nvery\tO\nlow\tO\n(\tO\n2\tO\n.\tO\n8\tO\nmicrogramg\tO\n/\tO\nml\tO\n)\tO\n.\tO\n\nThe\tO\nencephalopathy\tB-Disease\nwas\tO\nprobably\tO\nan\tO\nidiosyncratic\tO\nand\tO\nnot\tO\ntoxic\tO\nor\tO\nallergic\tO\nreaction\tO\n.\tO\n\nIn\tO\nfact\tO\nthe\tO\nconcentration\tO\nof\tO\nfree\tO\nDPH\tB-Chemical\nwas\tO\nnormal\tO\n,\tO\nthe\tO\npatient\tO\npresented\tO\na\tO\nretarded\tO\nmorbilliform\tO\nrash\tB-Disease\nduring\tO\nDPH\tB-Chemical\ntreatment\tO\n,\tO\nthe\tO\nprotidogram\tO\nwas\tO\nnormal\tO\n,\tO\nand\tO\nan\tO\nintradermic\tO\nDPH\tB-Chemical\ninjection\tO\nhad\tO\nno\tO\nlocal\tO\neffect\tO\n.\tO\n\nThe\tO\nauthors\tO\nconclude\tO\nthat\tO\nin\tO\na\tO\npatient\tO\nstarting\tO\nDPH\tB-Chemical\ntreatment\tO\nan\tO\nunexpected\tO\nincrease\tO\nin\tO\nseizures\tB-Disease\n,\tO\nwith\tO\nEEG\tO\nand\tO\nmental\tO\nchanges\tO\noccurring\tO\nsimultaneously\tO\n,\tO\nshould\tO\nalert\tO\nthe\tO\nphysician\tO\nto\tO\nthe\tO\npossible\tO\nneed\tO\nfor\tO\neliminating\tO\nDPH\tB-Chemical\nfrom\tO\nthe\tO\ntherapeutic\tO\nregimen\tO\n,\tO\neven\tO\nif\tO\nplasma\tO\nconcentrations\tO\nare\tO\nlow\tO\n.\tO\n\nPrevention\tO\nand\tO\ntreatment\tO\nof\tO\nendometrial\tB-Disease\ndisease\tI-Disease\nin\tO\nclimacteric\tO\nwomen\tO\nreceiving\tO\noestrogen\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\ntreatment\tO\nregimens\tO\nare\tO\ndescribed\tO\nin\tO\n74\tO\npatients\tO\nwith\tO\nendometrial\tB-Disease\ndisease\tI-Disease\namong\tO\n850\tO\nclimacteric\tO\nwomen\tO\nreceiving\tO\noestrogen\tB-Chemical\ntherapy\tO\n.\tO\n\nCystic\tO\nhyperplasia\tB-Disease\nwas\tO\nassociated\tO\nwith\tO\nunopposed\tO\noestrogen\tB-Chemical\ntherapy\tO\nwithout\tO\nprogestagen\tB-Chemical\n.\tO\n\nTwo\tO\ncourses\tO\nof\tO\n21\tO\ndays\tO\nof\tO\n5\tO\nmg\tO\nnorethisterone\tB-Chemical\ndaily\tO\ncaused\tO\nreversion\tO\nto\tO\nnormal\tO\nin\tO\nall\tO\n57\tO\ncases\tO\nof\tO\ncystic\tO\nhyperplasia\tB-Disease\nand\tO\n6\tO\nof\tO\nthe\tO\n8\tO\ncases\tO\nof\tO\natypical\tO\nhyperplasia\tB-Disease\n.\tO\n\n4\tO\ncases\tO\nof\tO\nendometrial\tB-Disease\ncarcinoma\tI-Disease\nreferred\tO\nfrom\tO\nelsewhere\tO\ndemonstrated\tO\nthe\tO\nproblems\tO\nof\tO\ninappropriate\tO\nand\tO\nunsupervised\tO\nunopposed\tO\noestrogen\tB-Chemical\ntherapy\tO\nand\tO\nthe\tO\ndifficulty\tO\nin\tO\ndistinguishing\tO\nsevere\tO\nhyperplasia\tB-Disease\nfrom\tO\nmalignancy\tB-Disease\n.\tO\n\nCyclical\tO\nlow\tO\n-\tO\ndose\tO\noestrogen\tB-Chemical\ntherapy\tO\nwith\tO\n7\tO\n-\tO\n-\tO\n13\tO\ndays\tO\nof\tO\nprogestagen\tB-Chemical\ndoes\tO\nnot\tO\nseem\tO\nto\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nendometrial\tB-Disease\nhyperplasia\tI-Disease\nor\tO\ncarcinoma\tB-Disease\n.\tO\n\nEffects\tO\nof\tO\nexercise\tO\non\tO\nthe\tO\nseverity\tO\nof\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nexercise\tO\non\tO\nthe\tO\nseverity\tO\nof\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nstudied\tO\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nNinety\tO\n-\tO\nthree\tO\nrats\tO\nwere\tO\nrandomly\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n.\tO\n\nThe\tO\nexercise\tO\n-\tO\nisoproterenol\tB-Chemical\n(\tO\nE\tO\n-\tO\n1\tO\n)\tO\nand\tO\nexercise\tO\ncontrol\tO\n(\tO\nEC\tO\n)\tO\ngroups\tO\nexercised\tO\ndaily\tO\nfor\tO\nthirty\tO\ndays\tO\non\tO\na\tO\ntreadmill\tO\nat\tO\n1\tO\nmph\tO\n,\tO\n2\tO\n%\tO\ngrade\tO\nwhile\tO\nanimals\tO\nof\tO\nthe\tO\nsedentary\tO\n-\tO\nisoproterenol\tB-Chemical\n(\tO\nS\tO\n-\tO\nI\tO\n)\tO\ngroup\tO\nremained\tO\nsedentary\tO\n.\tO\n\nEight\tO\nanimals\tO\nwere\tO\nassigned\tO\nto\tO\nthe\tO\nsedentary\tO\ncontrol\tO\n(\tO\nSC\tO\n)\tO\ngroup\tO\nwhich\tO\nremained\tO\nsedentary\tO\nthroughout\tO\nthe\tO\nexperimental\tO\nperiod\tO\n.\tO\n\nForty\tO\n-\tO\neight\tO\nhours\tO\nafter\tO\nthe\tO\nfinal\tO\nexercise\tO\nperiod\tO\n,\tO\nS\tO\n-\tO\nI\tO\nand\tO\nE\tO\n-\tO\nI\tO\nanimals\tO\nreceived\tO\na\tO\nsingle\tO\nsubcutaneous\tO\ninjection\tO\nof\tO\nisoproterenol\tB-Chemical\n(\tO\n250\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n)\tO\n.\tO\n\nAnimals\tO\nof\tO\nthe\tO\nS\tO\n-\tO\nI\tO\ngroup\tO\nexhibited\tO\nsignificantly\tO\n(\tO\nPp\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\ngreater\tO\nmortality\tO\nfrom\tO\nthe\tO\neffects\tO\nof\tO\nisoproterenol\tB-Chemical\nthan\tO\nanimals\tO\nof\tO\nthe\tO\nE\tO\n-\tO\nI\tO\ngroup\tO\n.\tO\n\nSerum\tO\nCPK\tO\nactivity\tO\nfor\tO\nE\tO\n-\tO\nI\tO\nanimals\tO\nwas\tO\nsignificantly\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\ngreater\tO\nthan\tO\nfor\tO\nanimals\tO\nin\tO\nthe\tO\nS\tO\n-\tO\nI\tO\nand\tO\nEC\tO\ngroups\tO\ntwenty\tO\nhours\tO\nfollowing\tO\nisoproterenol\tB-Chemical\ninjection\tO\n.\tO\n\nNo\tO\nstatistically\tO\nsignificant\tO\ndifferences\tO\nwere\tO\nobserved\tO\nbetween\tO\nthe\tO\ntwo\tO\nisoproterenol\tB-Chemical\ntreated\tO\ngroups\tO\nfor\tO\nseverity\tO\nof\tO\nthe\tO\ninduced\tO\nlesions\tO\n,\tO\nchanges\tO\nin\tO\nheart\tO\nweight\tO\n,\tO\nor\tO\nheart\tO\nweight\tO\nto\tO\nbody\tO\nweight\tO\nratios\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nexercise\tO\nreduced\tO\nthe\tO\nmortality\tO\nassociated\tO\nwith\tO\nthe\tO\neffects\tO\nof\tO\nlarge\tO\ndosages\tO\nof\tO\nisoproterenol\tB-Chemical\nbut\tO\nhad\tO\nlittle\tO\non\tO\nthe\tO\nseverity\tO\nof\tO\nthe\tO\ninfarction\tB-Disease\n.\tO\n\nHuman\tO\ncorticotropin\tB-Chemical\n-\tO\nreleasing\tO\nhormone\tO\nand\tO\nthyrotropin\tB-Chemical\n-\tO\nreleasing\tO\nhormone\tO\nmodulate\tO\nthe\tO\nhypercapnic\tB-Disease\nventilatory\tO\nresponse\tO\nin\tO\nhumans\tO\n.\tO\n\nHuman\tO\ncorticotropin\tB-Chemical\n-\tO\nreleasing\tO\nhormone\tO\n(\tO\nhCRH\tO\n)\tO\nand\tO\nthyrotropin\tB-Chemical\n-\tO\nreleasing\tO\nhormone\tO\n(\tO\nTRH\tO\n)\tO\nare\tO\nknown\tO\nto\tO\nstimulate\tO\nventilation\tO\nafter\tO\ni\tO\n.\tO\nv\tO\n.\tO\nadministration\tO\nin\tO\nhumans\tO\n.\tO\n\nIn\tO\na\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\nsingle\tO\n-\tO\nblind\tO\nstudy\tO\nwe\tO\naimed\tO\nto\tO\nclarify\tO\nif\tO\nboth\tO\npeptides\tO\nact\tO\nby\tO\naltering\tO\ncentral\tO\nchemosensitivity\tO\n.\tO\n\nTwo\tO\nsubsequent\tO\nCO2\tB-Chemical\n-\tO\nrebreathing\tO\ntests\tO\nwere\tO\nperformed\tO\nin\tO\nhealthy\tO\nyoung\tO\nvolunteers\tO\n.\tO\n\nDuring\tO\nthe\tO\nfirst\tO\ntest\tO\n0\tO\n.\tO\n9\tO\n%\tO\nNaCl\tB-Chemical\nwas\tO\ngiven\tO\ni\tO\n.\tO\nv\tO\n.\tO\n;\tO\nduring\tO\nthe\tO\nsecond\tO\ntest\tO\n200\tO\nmicrograms\tO\nof\tO\nhCRH\tO\n(\tO\nn\tO\n=\tO\n12\tO\n)\tO\nor\tO\n400\tO\nmicrograms\tO\nof\tO\nTRH\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nwas\tO\nadministered\tO\ni\tO\n.\tO\nv\tO\n.\tO\nNine\tO\nsubjects\tO\nreceived\tO\n0\tO\n.\tO\n9\tO\n%\tO\nNaCl\tB-Chemical\ni\tO\n.\tO\nv\tO\n.\tO\nduring\tO\nboth\tO\nrebreathing\tO\nmanoeuvres\tO\n.\tO\n\nThe\tO\nCO2\tB-Chemical\n-\tO\nresponse\tO\ncurves\tO\nfor\tO\nthe\tO\ntwo\tO\ntests\tO\nwere\tO\ncompared\tO\nwithin\tO\nthe\tO\nsame\tO\nsubject\tO\n.\tO\n\nIn\tO\nthe\tO\nhCRH\tO\ngroup\tO\na\tO\nmarked\tO\nparallel\tO\nshift\tO\nof\tO\nthe\tO\nCO2\tB-Chemical\n-\tO\nresponse\tO\ncurve\tO\nto\tO\nthe\tO\nleft\tO\nwas\tO\nobserved\tO\nafter\tO\nhCRH\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThe\tO\nsame\tO\neffect\tO\noccurred\tO\nfollowing\tO\nTRH\tO\nbut\tO\nwas\tO\nless\tO\nstriking\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nhCRH\tO\nand\tO\nTRH\tO\ncaused\tO\na\tO\nreduction\tO\nin\tO\nthe\tO\nCO2\tB-Chemical\nthreshold\tO\n.\tO\n\nThe\tO\nCO2\tB-Chemical\n-\tO\nresponse\tO\ncurves\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\nwere\tO\nnearly\tO\nidentical\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nan\tO\nadditive\tO\neffect\tO\nof\tO\nboth\tO\nreleasing\tO\nhormones\tO\non\tO\nthe\tO\nhypercapnic\tB-Disease\nventilatory\tO\nresponse\tO\nin\tO\nhumans\tO\n,\tO\npresumably\tO\nindependent\tO\nof\tO\ncentral\tO\nchemosensitivity\tO\n.\tO\n\nLamivudine\tB-Chemical\nis\tO\neffective\tO\nin\tO\nsuppressing\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\nDNA\tO\nin\tO\nChinese\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nsurface\tI-Chemical\nantigen\tI-Chemical\ncarriers\tO\n:\tO\na\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrial\tO\n.\tO\n\nLamivudine\tB-Chemical\nis\tO\na\tO\nnovel\tO\n2\tB-Chemical\n'\tI-Chemical\n,\tI-Chemical\n3\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\ndideoxy\tI-Chemical\ncytosine\tI-Chemical\nanalogue\tO\nthat\tO\nhas\tO\npotent\tO\ninhibitory\tO\neffects\tO\non\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\nreplication\tO\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\n.\tO\n\nWe\tO\nperformed\tO\na\tO\nsingle\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\nstudy\tO\nto\tO\nassess\tO\nits\tO\neffectiveness\tO\nand\tO\nsafety\tO\nin\tO\nChinese\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nsurface\tI-Chemical\nantigen\tI-Chemical\n(\tO\nHBsAg\tB-Chemical\n)\tO\ncarriers\tO\n.\tO\n\nForty\tO\n-\tO\ntwo\tO\nChinese\tO\nHBsAg\tB-Chemical\ncarriers\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\nplacebo\tO\n(\tO\n6\tO\npatients\tO\n)\tO\nor\tO\nlamivudine\tB-Chemical\norally\tO\nin\tO\ndosages\tO\nof\tO\n25\tO\nmg\tO\n,\tO\n100\tO\nmg\tO\n,\tO\nor\tO\n300\tO\nmg\tO\ndaily\tO\n(\tO\n12\tO\npatients\tO\nfor\tO\neach\tO\ndosage\tO\n)\tO\n.\tO\n\nThe\tO\ndrug\tO\nwas\tO\ngiven\tO\nfor\tO\n4\tO\nweeks\tO\n.\tO\n\nThe\tO\npatients\tO\nwere\tO\nclosely\tO\nmonitored\tO\nclinically\tO\n,\tO\nbiochemically\tO\n,\tO\nand\tO\nserologically\tO\nup\tO\nto\tO\n4\tO\nweeks\tO\nafter\tO\ndrug\tO\ntreatment\tO\n.\tO\n\nAll\tO\n36\tO\npatients\tO\nreceiving\tO\nlamivudine\tB-Chemical\nhad\tO\na\tO\ndecrease\tO\nin\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\n(\tO\nHBV\tO\n)\tO\nDNA\tO\nvalues\tO\nof\tO\n>\tO\n90\tO\n%\tO\n(\tO\nP\tO\n<\tO\n.\tO\n001\tO\ncompared\tO\nwith\tO\nplacebo\tO\n)\tO\n.\tO\n\nAlthough\tO\n25\tO\nmg\tO\nof\tO\nlamivudine\tB-Chemical\nwas\tO\nslightly\tO\nless\tO\neffective\tO\nthan\tO\n100\tO\nmg\tO\n(\tO\nP\tO\n=\tO\n.\tO\n011\tO\n)\tO\nand\tO\n300\tO\nmg\tO\n(\tO\nP\tO\n=\tO\n.\tO\n005\tO\n)\tO\n,\tO\nit\tO\nstill\tO\ninduced\tO\n94\tO\n%\tO\nsuppression\tO\nof\tO\nHBV\tO\nDNA\tO\nafter\tO\nthe\tO\nfourth\tO\nweek\tO\nof\tO\ntherapy\tO\n.\tO\n\nHBV\tO\nDNA\tO\nvalues\tO\nreturned\tO\nto\tO\npretreatment\tO\nlevels\tO\nwithin\tO\n4\tO\nweeks\tO\nof\tO\ncessation\tO\nof\tO\ntherapy\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nchange\tO\nin\tO\nthe\tO\nhepatitis\tB-Disease\nB\tI-Disease\ne\tO\nantigen\tO\nstatus\tO\nor\tO\nin\tO\naminotransferase\tO\nlevels\tO\n.\tO\n\nNo\tO\nserious\tO\nadverse\tO\nevents\tO\nwere\tO\nobserved\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\na\tO\n4\tO\n-\tO\nweek\tO\ncourse\tO\nof\tO\nlamivudine\tB-Chemical\nwas\tO\nsafe\tO\nand\tO\neffective\tO\nin\tO\nsuppression\tO\nof\tO\nHBV\tO\nDNA\tO\nin\tO\nChinese\tO\nHBsAg\tB-Chemical\ncarriers\tO\n.\tO\n\nThe\tO\nsuppression\tO\nwas\tO\n>\tO\n90\tO\n%\tO\nbut\tO\nreversible\tO\n.\tO\n\nStudies\tO\nwith\tO\nlong\tO\n-\tO\nterm\tO\nlamivudine\tB-Chemical\nadministration\tO\nshould\tO\nbe\tO\nperformed\tO\nto\tO\ndetermine\tO\nif\tO\nprolonged\tO\nsuppression\tO\nof\tO\nHBV\tO\nDNA\tO\ncan\tO\nbe\tO\nachieved\tO\n.\tO\n\nPopulation\tO\n-\tO\nbased\tO\nstudy\tO\nof\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\nassociated\tO\nwith\tO\nvarious\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nFour\tO\nstudies\tO\npublished\tO\nsince\tO\nDecember\tO\n,\tO\n1995\tO\n,\tO\nreported\tO\nthat\tO\nthe\tO\nincidence\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tB-Disease\n)\tO\nwas\tO\nhigher\tO\nin\tO\nwomen\tO\nwho\tO\nused\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n(\tO\nOCs\tB-Chemical\n)\tO\ncontaining\tO\nthe\tO\nthird\tO\n-\tO\ngeneration\tO\nprogestagens\tB-Chemical\ngestodene\tB-Chemical\nor\tO\ndesogestrel\tB-Chemical\nthan\tO\nin\tO\nusers\tO\nof\tO\nOCs\tB-Chemical\ncontaining\tO\nsecond\tO\n-\tO\ngeneration\tO\nprogestagens\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nconfounding\tO\nand\tO\nbias\tO\nin\tO\nthe\tO\ndesign\tO\nof\tO\nthese\tO\nstudies\tO\nmay\tO\nhave\tO\naffected\tO\nthe\tO\nfindings\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nour\tO\nstudy\tO\nwas\tO\nto\tO\nre\tO\n-\tO\nexamine\tO\nthe\tO\nassociation\tO\nbetween\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nand\tO\nOC\tB-Chemical\nuse\tO\nwith\tO\na\tO\ndifferent\tO\nstudy\tO\ndesign\tO\nand\tO\nanalysis\tO\nto\tO\navoid\tO\nsome\tO\nof\tO\nthe\tO\nbias\tO\nand\tO\nconfounding\tO\nof\tO\nthe\tO\nearlier\tO\nstudies\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nused\tO\ncomputer\tO\nrecords\tO\nof\tO\npatients\tO\nfrom\tO\n143\tO\ngeneral\tO\npractices\tO\nin\tO\nthe\tO\nUK\tO\n.\tO\n\nThe\tO\nstudy\tO\nwas\tO\nbased\tO\non\tO\nthe\tO\nmedical\tO\nrecords\tO\nof\tO\nabout\tO\n540\tO\n,\tO\n000\tO\nwomen\tO\nborn\tO\nbetween\tO\n1941\tO\nand\tO\n1981\tO\n.\tO\n\nAll\tO\nwomen\tO\nwho\tO\nhad\tO\na\tO\nrecorded\tO\ndiagnosis\tO\nof\tO\ndeep\tB-Disease\n-\tI-Disease\nvein\tI-Disease\nthrombosis\tI-Disease\n,\tO\nvenous\tB-Disease\nthrombosis\tI-Disease\nnot\tO\notherwise\tO\nspecified\tO\n,\tO\nor\tO\npulmonary\tO\nembolus\tO\nduring\tO\nthe\tO\nstudy\tO\nperiod\tO\n,\tO\nand\tO\nwho\tO\nhad\tO\nbeen\tO\ntreated\tO\nwith\tO\nan\tO\nanticoagulant\tO\nwere\tO\nidentified\tO\nas\tO\npotential\tO\ncases\tO\nof\tO\nVTE\tB-Disease\n.\tO\n\nWe\tO\ndid\tO\na\tO\ncohort\tO\nanalysis\tO\nto\tO\nestimate\tO\nand\tO\ncompare\tO\nincidence\tO\nof\tO\nVTE\tB-Disease\nin\tO\nusers\tO\nof\tO\nthe\tO\nmain\tO\nOC\tB-Chemical\npreparations\tO\n,\tO\nand\tO\na\tO\nnested\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nto\tO\ncalculate\tO\nthe\tO\nodds\tO\nratios\tO\nof\tO\nVTE\tB-Disease\nassociated\tO\nwith\tO\nuse\tO\nof\tO\ndifferent\tO\ntypes\tO\nof\tO\nOC\tB-Chemical\n,\tO\nafter\tO\nadjustment\tO\nfor\tO\npotential\tO\nconfounding\tO\nfactors\tO\n.\tO\n\nIn\tO\nthe\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n,\tO\nwe\tO\nmatched\tO\ncases\tO\nto\tO\ncontrols\tO\nby\tO\nexact\tO\nyear\tO\nof\tO\nbirth\tO\n,\tO\npractice\tO\n,\tO\nand\tO\ncurrent\tO\nuse\tO\nof\tO\nOCs\tB-Chemical\n.\tO\n\nWe\tO\nused\tO\na\tO\nmultiple\tO\nlogistic\tO\nregression\tO\nmodel\tO\nthat\tO\nincluded\tO\nbody\tO\n-\tO\nmass\tO\nindex\tO\n,\tO\nnumber\tO\nof\tO\ncycles\tO\n,\tO\nchange\tO\nin\tO\ntype\tO\nof\tO\nOC\tB-Chemical\nprescribed\tO\nwithin\tO\n3\tO\nmonths\tO\nof\tO\nthe\tO\nevent\tO\n,\tO\nprevious\tO\npregnancy\tO\n,\tO\nand\tO\nconcurrent\tO\ndisease\tO\n.\tO\n\nFINDINGS\tO\n:\tO\n85\tO\nwomen\tO\nmet\tO\nthe\tO\ninclusion\tO\ncriteria\tO\nfor\tO\nVTE\tB-Disease\n,\tO\ntwo\tO\nof\tO\nwhom\tO\nwere\tO\nusers\tO\nof\tO\nprogestagen\tB-Chemical\n-\tO\nonly\tO\nOCs\tB-Chemical\n.\tO\n\nOf\tO\nthe\tO\n83\tO\ncases\tO\nof\tO\nVTE\tB-Disease\nassociated\tO\nwith\tO\nuse\tO\nof\tO\ncombined\tO\nOCs\tB-Chemical\n,\tO\n43\tO\nwere\tO\nrecorded\tO\nas\tO\ndeep\tB-Disease\n-\tI-Disease\nvein\tI-Disease\nthrombosis\tI-Disease\n,\tO\n35\tO\nas\tO\npulmonary\tO\nthrombosis\tB-Disease\n,\tO\nand\tO\nfive\tO\nas\tO\nvenous\tB-Disease\nthrombosis\tI-Disease\nnot\tO\notherwise\tO\nspecified\tO\n.\tO\n\nThe\tO\ncrude\tO\nrate\tO\nof\tO\nVTE\tB-Disease\nper\tO\n10\tO\n,\tO\n000\tO\nwoman\tO\n-\tO\nyears\tO\nwas\tO\n4\tO\n.\tO\n10\tO\nin\tO\ncurrent\tO\nusers\tO\nof\tO\nany\tO\nOC\tB-Chemical\n,\tO\n3\tO\n.\tO\n10\tO\nin\tO\nusers\tO\nof\tO\nsecond\tO\n-\tO\ngeneration\tO\nOCs\tB-Chemical\n,\tO\nand\tO\n4\tO\n.\tO\n96\tO\nin\tO\nusers\tO\nof\tO\nthird\tO\n-\tO\ngeneration\tO\npreparations\tO\n.\tO\n\nAfter\tO\nadjustment\tO\nfor\tO\nage\tO\n,\tO\nthe\tO\nrate\tO\nratio\tO\nof\tO\nVTE\tB-Disease\nin\tO\nusers\tO\nof\tO\nthird\tO\n-\tO\ngeneration\tO\nrelative\tO\nto\tO\nsecond\tO\n-\tO\ngeneration\tO\nOCs\tB-Chemical\nwas\tO\n1\tO\n.\tO\n68\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n04\tO\n-\tO\n2\tO\n.\tO\n75\tO\n)\tO\n.\tO\n\nLogistic\tO\nregression\tO\nshowed\tO\nno\tO\nsignificant\tO\ndifference\tO\nin\tO\nthe\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nbetween\tO\nusers\tO\nof\tO\nthird\tO\n-\tO\ngeneration\tO\nand\tO\nsecond\tO\n-\tO\ngeneration\tO\nOCs\tB-Chemical\n.\tO\n\nAmong\tO\nusers\tO\nof\tO\nthird\tO\n-\tO\ngeneration\tO\nprogestagens\tB-Chemical\n,\tO\nthe\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nwas\tO\nhigher\tO\nin\tO\nusers\tO\nof\tO\ndesogestrel\tB-Chemical\nwith\tO\n20\tO\ng\tO\nethinyloestradiol\tB-Chemical\nthan\tO\nin\tO\nusers\tO\nof\tO\ngestodene\tB-Chemical\nor\tO\ndesogestrel\tB-Chemical\nwith\tO\n30\tO\ng\tO\nethinyloestradiol\tB-Chemical\n.\tO\n\nWith\tO\nall\tO\nsecond\tO\n-\tO\ngeneration\tO\nOCs\tB-Chemical\nas\tO\nthe\tO\nreference\tO\n,\tO\nthe\tO\nodds\tO\nratios\tO\nfor\tO\nVTE\tB-Disease\nwere\tO\n3\tO\n.\tO\n49\tO\n(\tO\n1\tO\n.\tO\n21\tO\n-\tO\n10\tO\n.\tO\n12\tO\n)\tO\nfor\tO\ndesogestrel\tB-Chemical\nplus\tO\n20\tO\ng\tO\nethinyloestradiol\tB-Chemical\nand\tO\n1\tO\n.\tO\n18\tO\n(\tO\n0\tO\n.\tO\n66\tO\n-\tO\n2\tO\n.\tO\n17\tO\n)\tO\nfor\tO\nthe\tO\nother\tO\nthird\tO\n-\tO\ngeneration\tO\nprogestagens\tB-Chemical\n.\tO\n\nINTERPRETATION\tO\n:\tO\nThe\tO\npreviously\tO\nreported\tO\nincrease\tO\nin\tO\nodds\tO\nratio\tO\nassociated\tO\nwith\tO\nthird\tO\n-\tO\ngeneration\tO\nOCs\tB-Chemical\nwhen\tO\ncompared\tO\nwith\tO\nsecond\tO\n-\tO\ngeneration\tO\nproducts\tO\nis\tO\nlikely\tO\nto\tO\nhave\tO\nbeen\tO\nthe\tO\nresult\tO\nof\tO\nresidual\tO\nconfounding\tO\nby\tO\nage\tO\n.\tO\n\nThe\tO\nincreased\tO\nodds\tO\nratio\tO\nassociated\tO\nwith\tO\nproducts\tO\ncontaining\tO\n20\tO\nmicrograms\tO\nethinyloestradiol\tB-Chemical\nand\tO\ndesogestrel\tB-Chemical\ncompared\tO\nwith\tO\nthe\tO\n30\tO\nmicrograms\tO\nproduct\tO\nis\tO\nbiologically\tO\nimplausible\tO\n,\tO\nand\tO\nis\tO\nlikely\tO\nto\tO\nbe\tO\nthe\tO\nresult\tO\nof\tO\npreferential\tO\nprescribing\tO\nand\tO\n,\tO\nthus\tO\n,\tO\nconfounding\tO\n.\tO\n\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\naugments\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nelectrographic\tO\nseizure\tB-Disease\nbut\tO\nprotects\tO\nagainst\tO\nbrain\tB-Disease\ndamage\tI-Disease\nin\tO\nrats\tO\n.\tO\n\n1\tO\n.\tO\n\nThe\tO\nauthors\tO\nexamined\tO\nthe\tO\nanticonvulsant\tO\neffects\tO\nof\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\non\tO\nthe\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizure\tB-Disease\nmodel\tO\n.\tO\n\nIntraperitoneal\tO\ninjection\tO\nof\tO\npilocarpine\tB-Chemical\n(\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ninduced\tO\ntonic\tB-Disease\nand\tI-Disease\nclonic\tI-Disease\nseizure\tI-Disease\n.\tO\n\nScopolamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\npentobarbital\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nprevented\tO\ndevelopment\tO\nof\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nbehavioral\tO\nseizure\tB-Disease\nbut\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ndid\tO\nnot\tO\n.\tO\n\n2\tO\n.\tO\n\nAn\tO\nelectrical\tO\nseizure\tB-Disease\nmeasured\tO\nwith\tO\nhippocampal\tO\nEEG\tO\nappeared\tO\nin\tO\nthe\tO\npilocarpine\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\n.\tO\n\nScopolamine\tB-Chemical\nand\tO\npentobarbital\tB-Chemical\nblocked\tO\nthe\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nelectrographic\tO\nseizure\tB-Disease\n,\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\ntreatment\tO\naugmented\tO\nthe\tO\nelectrographic\tO\nseizure\tB-Disease\ninduced\tO\nby\tO\npilocarpine\tB-Chemical\n.\tO\n\n3\tO\n.\tO\n\nBrain\tB-Disease\ndamage\tI-Disease\nwas\tO\nassessed\tO\nby\tO\nexamining\tO\nthe\tO\nhippocampus\tO\nmicroscopically\tO\n.\tO\n\nPilocarpine\tB-Chemical\nproduced\tO\nneuronal\tB-Disease\ndeath\tI-Disease\nin\tO\nthe\tO\nhippocampus\tO\n,\tO\nwhich\tO\nshowed\tO\npyknotic\tO\nchanges\tO\n.\tO\n\nPentobarbital\tB-Chemical\n,\tO\nscopolamine\tB-Chemical\nand\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\nprotected\tO\nthe\tO\nbrain\tB-Disease\ndamage\tI-Disease\nby\tO\npilocarpine\tB-Chemical\n,\tO\nthough\tO\nin\tO\nthe\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n-\tO\ntreated\tO\ngroup\tO\n,\tO\nthe\tO\npyramidal\tO\ncells\tO\nof\tO\nhippocampus\tO\nappeared\tO\ndarker\tO\nthan\tO\nnormal\tO\n.\tO\n\nIn\tO\nall\tO\ntreatments\tO\n,\tO\ngranule\tO\ncells\tO\nof\tO\nthe\tO\ndentate\tO\ngyrus\tO\nwere\tO\nnot\tO\naffected\tO\n.\tO\n\n4\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\ninduced\tO\nby\tO\npilocarpine\tB-Chemical\nis\tO\ninitiated\tO\nby\tO\ncholinergic\tO\noverstimulation\tO\nand\tO\npropagated\tO\nby\tO\nglutamatergic\tO\ntransmission\tO\n,\tO\nthe\tO\nelevation\tO\nof\tO\nwhich\tO\nmay\tO\ncause\tO\nbrain\tB-Disease\ndamage\tI-Disease\nthrough\tO\nan\tO\nexcitatory\tO\nNMDA\tB-Chemical\nreceptor\tO\n-\tO\nmediated\tO\nmechanism\tO\n.\tO\n\nPaclitaxel\tB-Chemical\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n,\tO\nand\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\nin\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\n:\tO\nBRE\tO\n-\tO\n26\tO\n,\tO\na\tO\nphase\tO\nII\tO\ntrial\tO\n.\tO\n\n5\tB-Chemical\n-\tI-Chemical\nFluorouracil\tI-Chemical\nplus\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\nand\tO\npaclitaxel\tB-Chemical\n(\tO\nTaxol\tB-Chemical\n;\tO\nBristol\tO\n-\tO\nMyers\tO\nSquibb\tO\nCompany\tO\n,\tO\nPrinceton\tO\n,\tO\nNJ\tO\n)\tO\nare\tO\neffective\tO\nsalvage\tO\ntherapies\tO\nfor\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\npatients\tO\n.\tO\n\nPaclitaxel\tB-Chemical\nand\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\nhave\tO\nadditive\tO\ncytotoxicity\tB-Disease\nin\tO\nMCF\tO\n-\tO\n7\tO\ncell\tO\nlines\tO\n.\tO\n\nWe\tO\nperformed\tO\na\tO\nphase\tO\nII\tO\ntrial\tO\nof\tO\npaclitaxel\tB-Chemical\n175\tO\nmg\tO\n/\tO\nm2\tO\nover\tO\n3\tO\nhours\tO\non\tO\nday\tO\nI\tO\nfollowed\tO\nby\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\n300\tO\nmg\tO\nover\tO\n1\tO\nhour\tO\nbefore\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n350\tO\nmg\tO\n/\tO\nm2\tO\non\tO\ndays\tO\n1\tO\nto\tO\n3\tO\nevery\tO\n28\tO\ndays\tO\n(\tO\nTFL\tO\n)\tO\nin\tO\nwomen\tO\nwith\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nAnalysis\tO\nis\tO\nreported\tO\non\tO\n37\tO\npatients\tO\nwith\tO\na\tO\nminimum\tO\nof\tO\n6\tO\nmonths\tO\nfollow\tO\n-\tO\nup\tO\nwho\tO\nreceived\tO\na\tO\ntotal\tO\nof\tO\n192\tO\ncycles\tO\nof\tO\nTFL\tO\n:\tO\nnine\tO\ncycles\tO\n(\tO\n5\tO\n%\tO\n)\tO\nwere\tO\nassociated\tO\nwith\tO\ngrade\tO\n3\tO\n/\tO\n4\tO\nneutropenia\tB-Disease\nrequiring\tO\nhospitalization\tO\n;\tO\nseven\tO\n(\tO\n4\tO\n%\tO\n)\tO\ncycles\tO\nin\tO\ntwo\tO\npatients\tO\nrequired\tO\ngranulocyte\tB-Chemical\ncolony\tI-Chemical\n-\tI-Chemical\nstimulating\tI-Chemical\nfactor\tI-Chemical\ndue\tO\nto\tO\nneutropenia\tB-Disease\n;\tO\nno\tO\npatient\tO\nrequired\tO\nplatelet\tO\ntransfusions\tO\n.\tO\n\nGrade\tO\n3\tO\n/\tO\n4\tO\nnonhematologic\tO\ntoxicities\tB-Disease\nwere\tO\nuncommon\tO\n.\tO\n\nAmong\tO\nthe\tO\n34\tO\npatients\tO\nevaluable\tO\nfor\tO\nresponse\tO\n,\tO\nthere\tO\nwere\tO\nthree\tO\ncomplete\tO\nresponses\tO\n(\tO\n9\tO\n%\tO\n)\tO\nand\tO\n18\tO\npartial\tO\nresponses\tO\n(\tO\n53\tO\n%\tO\n)\tO\nfor\tO\nan\tO\noverall\tO\nresponse\tO\nrate\tO\nof\tO\n62\tO\n%\tO\n.\tO\n\nOf\tO\nthe\tO\n19\tO\nevaluable\tO\npatients\tO\nwith\tO\nprior\tO\ndoxorubicin\tB-Chemical\nexposure\tO\n,\tO\n11\tO\n(\tO\n58\tO\n%\tO\n)\tO\nresponded\tO\ncompared\tO\nwith\tO\nnine\tO\nof\tO\n15\tO\n(\tO\n60\tO\n%\tO\n)\tO\nwithout\tO\nprior\tO\ndoxorubicin\tB-Chemical\n.\tO\n\nPlasma\tO\npaclitaxel\tB-Chemical\nconcentrations\tO\nwere\tO\nmeasured\tO\nat\tO\nthe\tO\ncompletion\tO\nof\tO\npaclitaxel\tB-Chemical\ninfusion\tO\nand\tO\nat\tO\n24\tO\nhours\tO\nin\tO\n19\tO\npatients\tO\n.\tO\n\nTFL\tO\nis\tO\nan\tO\nactive\tO\n,\tO\nwell\tO\n-\tO\ntolerated\tO\nregimen\tO\nin\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nEfficacy\tO\nand\tO\nproarrhythmia\tB-Disease\nwith\tO\nthe\tO\nuse\tO\nof\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\nfor\tO\nsustained\tO\nventricular\tB-Disease\ntachyarrhythmias\tI-Disease\n.\tO\n\nThis\tO\nstudy\tO\nprospectively\tO\nevaluated\tO\nthe\tO\nclinical\tO\nefficacy\tO\n,\tO\nthe\tO\nincidence\tO\nof\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n,\tO\nand\tO\nthe\tO\npresumable\tO\nrisk\tO\nfactors\tO\nfor\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\nfor\tO\nsustained\tO\nventricular\tB-Disease\ntachyarrhythmias\tI-Disease\n.\tO\n\nEighty\tO\n-\tO\none\tO\nconsecutive\tO\npatients\tO\n(\tO\n54\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n,\tO\nand\tO\n20\tO\nwith\tO\ndilated\tB-Disease\ncardiomyopathy\tI-Disease\n)\tO\nwith\tO\ninducible\tO\nsustained\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nor\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nreceived\tO\noral\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\nto\tO\nprevent\tO\ninduction\tO\nof\tO\nthe\tO\nventricular\tB-Disease\ntachyarrhythmia\tI-Disease\n.\tO\n\nDuring\tO\noral\tO\nloading\tO\nwith\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\n,\tO\ncontinuous\tO\nelectrocardiographic\tO\n(\tO\nECG\tO\n)\tO\nmonitoring\tO\nwas\tO\nperformed\tO\n.\tO\n\nThose\tO\npatients\tO\nin\tO\nwhom\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\nprevented\tO\ninduction\tO\nof\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nor\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nwere\tO\ndischarged\tO\nwith\tO\nthe\tO\ndrug\tO\nand\tO\nfollowed\tO\nup\tO\non\tO\nan\tO\noutpatient\tO\nbasis\tO\nfor\tO\n21\tO\n+\tO\n/\tO\n-\tO\n18\tO\nmonths\tO\n.\tO\n\nInduction\tO\nof\tO\nthe\tO\nventricular\tB-Disease\ntachyarrhythmia\tI-Disease\nwas\tO\nprevented\tO\nby\tO\noral\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\nin\tO\n35\tO\n(\tO\n43\tO\n%\tO\n)\tO\npatients\tO\n;\tO\nthe\tO\nventricular\tB-Disease\ntachyarrhythmia\tI-Disease\nremained\tO\ninducible\tO\nin\tO\n40\tO\n(\tO\n49\tO\n%\tO\n)\tO\npatients\tO\n;\tO\nand\tO\ntwo\tO\n(\tO\n2\tO\n.\tO\n5\tO\n%\tO\n)\tO\npatients\tO\ndid\tO\nnot\tO\ntolerate\tO\neven\tO\n40\tO\nmg\tO\nof\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\nonce\tO\ndaily\tO\n.\tO\n\nFour\tO\n(\tO\n5\tO\n%\tO\n)\tO\npatients\tO\nhad\tO\nfrom\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nduring\tO\nthe\tO\ninitial\tO\noral\tO\ntreatment\tO\nwith\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\n.\tO\n\nNeither\tO\nECG\tO\n[\tO\nsinus\tO\n-\tO\ncycle\tO\nlength\tO\n(\tO\nSCL\tO\n)\tO\n,\tO\nQT\tO\nor\tO\nQTc\tO\ninterval\tO\n,\tO\nor\tO\nU\tO\nwave\tO\n]\tO\nnor\tO\nclinical\tO\nparameters\tO\nidentified\tO\npatients\tO\nat\tO\nrisk\tO\nfor\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\noral\tO\ndose\tO\nof\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\nwas\tO\nsignificantly\tO\nlower\tO\nin\tO\npatients\tO\nwith\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\n200\tO\n+\tO\n/\tO\n-\tO\n46\tO\nvs\tO\n.\tO\n328\tO\n+\tO\n/\tO\n-\tO\n53\tO\nmg\tO\n/\tO\nday\tO\n;\tO\np\tO\n=\tO\n0\tO\n.\tO\n0017\tO\n)\tO\n.\tO\n\nRisk\tO\nfactors\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nwere\tO\nthe\tO\nappearance\tO\nof\tO\nan\tO\nU\tO\nwave\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n049\tO\n)\tO\n,\tO\nfemale\tO\ngender\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n015\tO\n)\tO\n,\tO\nand\tO\nsignificant\tO\ndose\tO\n-\tO\ncorrected\tO\nchanges\tO\nof\tO\nSCL\tO\n,\tO\nQT\tO\ninterval\tO\n,\tO\nand\tO\nQTc\tO\ninterval\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nDuring\tO\nfollow\tO\n-\tO\nup\tO\n,\tO\nseven\tO\n(\tO\n20\tO\n%\tO\n)\tO\npatients\tO\nhad\tO\na\tO\nnonfatal\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nrecurrence\tO\n,\tO\nand\tO\ntwo\tO\n(\tO\n6\tO\n%\tO\n)\tO\npatients\tO\ndied\tO\nsuddenly\tO\n.\tO\n\nOne\tO\nfemale\tO\npatient\tO\nwith\tO\nstable\tO\ncardiac\tB-Disease\ndisease\tI-Disease\nhad\tO\nrecurrent\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nafter\tO\n2\tO\nyears\tO\nof\tO\nsuccessful\tO\ntreatment\tO\nwith\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\n.\tO\n\nTorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\noccurred\tO\nearly\tO\nduring\tO\ntreatment\tO\neven\tO\nwith\tO\nlow\tO\ndoses\tO\nof\tO\noral\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\n.\tO\n\nPronounced\tO\nchanges\tO\nin\tO\nthe\tO\nsurface\tO\nECG\tO\n(\tO\ncycle\tO\nlength\tO\n,\tO\nQT\tO\n,\tO\nand\tO\nQTc\tO\n)\tO\nin\tO\nrelation\tO\nto\tO\nthe\tO\ndose\tO\nof\tO\noral\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\nmight\tO\nidentify\tO\na\tO\nsubgroup\tO\nof\tO\npatients\tO\nwith\tO\nan\tO\nincreased\tO\nrisk\tO\nfor\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n.\tO\n\nOther\tO\nECG\tO\nparameters\tO\nbefore\tO\nthe\tO\napplication\tO\nof\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\ndid\tO\nnot\tO\nidentify\tO\npatients\tO\nat\tO\nincreased\tO\nrisk\tO\nfor\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n.\tO\n\nRecurrence\tO\nrates\tO\nof\tO\nventricular\tB-Disease\ntachyarrhythmias\tI-Disease\nare\tO\nhigh\tO\ndespite\tO\ncomplete\tO\nsuppression\tO\nof\tO\nthe\tO\narrhythmia\tB-Disease\nduring\tO\nprogrammed\tO\nstimulation\tO\n.\tO\n\nTherefore\tO\nprogrammed\tO\nelectrical\tO\nstimulation\tO\nin\tO\nthe\tO\ncase\tO\nof\tO\nd\tB-Chemical\n,\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nsotalol\tI-Chemical\nseems\tO\nto\tO\nbe\tO\nof\tO\nlimited\tO\nprognostic\tO\nvalue\tO\n.\tO\n\nChronic\tO\nhyperprolactinemia\tB-Disease\nand\tO\nchanges\tO\nin\tO\ndopamine\tB-Chemical\nneurons\tO\n.\tO\n\nThe\tO\ntuberoinfundibular\tO\ndopaminergic\tO\n(\tO\nTIDA\tO\n)\tO\nsystem\tO\nis\tO\nknown\tO\nto\tO\ninhibit\tO\nprolactin\tO\n(\tO\nPRL\tO\n)\tO\nsecretion\tO\n.\tO\n\nIn\tO\nyoung\tO\nanimals\tO\nthis\tO\nsystem\tO\nresponds\tO\nto\tO\nacute\tO\nelevations\tO\nin\tO\nserum\tO\nPRL\tO\nby\tO\nincreasing\tO\nits\tO\nactivity\tO\n.\tO\n\nHowever\tO\n,\tO\nthis\tO\nresponsiveness\tO\nis\tO\nlost\tO\nin\tO\naging\tO\nrats\tO\nwith\tO\nchronically\tO\nhigh\tO\nserum\tO\nPRL\tO\nlevels\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ninduce\tO\nhyperprolactinemia\tB-Disease\nin\tO\nrats\tO\nfor\tO\nextended\tO\nperiods\tO\nof\tO\ntime\tO\nand\tO\nexamine\tO\nits\tO\neffects\tO\non\tO\ndopaminergic\tO\nsystems\tO\nin\tO\nthe\tO\nbrain\tO\n.\tO\n\nHyperprolactinemia\tB-Disease\nwas\tO\ninduced\tO\nby\tO\ntreatment\tO\nwith\tO\nhaloperidol\tB-Chemical\n,\tO\na\tO\ndopamine\tB-Chemical\nreceptor\tO\nantagonist\tO\n,\tO\nand\tO\nPalkovits\tO\n'\tO\nmicrodissection\tO\ntechnique\tO\nin\tO\ncombination\tO\nwith\tO\nhigh\tO\n-\tO\nperformance\tO\nliquid\tO\nchromatography\tO\nwas\tO\nused\tO\nto\tO\nmeasure\tO\nneurotransmitter\tO\nconcentrations\tO\nin\tO\nseveral\tO\nareas\tO\nof\tO\nthe\tO\nbrain\tO\n.\tO\n\nAfter\tO\n6\tO\nmonths\tO\nof\tO\nhyperprolactinemia\tB-Disease\n,\tO\ndopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\nconcentrations\tO\nin\tO\nthe\tO\nmedian\tO\neminence\tO\n(\tO\nME\tO\n)\tO\nincreased\tO\nby\tO\n84\tO\n%\tO\nover\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nNine\tO\nmonths\tO\nof\tO\nhyperprolactinemia\tB-Disease\nproduced\tO\na\tO\n50\tO\n%\tO\nincrease\tO\nin\tO\nDA\tB-Chemical\nconcentrations\tO\nin\tO\nthe\tO\nME\tO\nover\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nHowever\tO\n,\tO\nDA\tB-Chemical\nresponse\tO\nwas\tO\nlost\tO\nif\tO\na\tO\n9\tO\n-\tO\nmonth\tO\nlong\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\nhyperprolactinemia\tB-Disease\nwas\tO\nfollowed\tO\nby\tO\na\tO\n1\tO\n1\tO\n/\tO\n2\tO\nmonth\tO\n-\tO\nlong\tO\nextremely\tO\nhigh\tO\nincrease\tO\nin\tO\nserum\tO\nPRL\tO\nlevels\tO\nproduced\tO\nby\tO\nimplantation\tO\nof\tO\nMMQ\tO\ncells\tO\nunder\tO\nthe\tO\nkidney\tO\ncapsule\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nchange\tO\nin\tO\nthe\tO\nlevels\tO\nof\tO\nDA\tB-Chemical\n,\tO\nnorepinephrine\tB-Chemical\n(\tO\nNE\tB-Chemical\n)\tO\n,\tO\nserotonin\tB-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n)\tO\n,\tO\nor\tO\ntheir\tO\nmetabolites\tO\nin\tO\nthe\tO\narcuate\tO\nnucleus\tO\n(\tO\nAN\tO\n)\tO\n,\tO\nmedial\tO\npreoptic\tO\narea\tO\n(\tO\nMPA\tO\n)\tO\n,\tO\ncaudate\tO\nputamen\tO\n(\tO\nCP\tO\n)\tO\n,\tO\nsubstantia\tO\nnigra\tO\n(\tO\nSN\tO\n)\tO\n,\tO\nand\tO\nzona\tO\nincerta\tO\n(\tO\nZI\tO\n)\tO\n,\tO\nexcept\tO\nfor\tO\na\tO\ndecrease\tO\nin\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxyindoleacetic\tI-Chemical\nacid\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHIAA\tI-Chemical\n)\tO\nin\tO\nthe\tO\nAN\tO\nafter\tO\n6\tO\n-\tO\nmonths\tO\nof\tO\nhyperprolactinemia\tB-Disease\nand\tO\nan\tO\nincrease\tO\nin\tO\nDA\tB-Chemical\nconcentrations\tO\nin\tO\nthe\tO\nAN\tO\nafter\tO\n9\tO\n-\tO\nmonths\tO\nof\tO\nhyperprolactinemia\tB-Disease\n.\tO\n\nThese\tO\nresults\tO\ndemonstrate\tO\nthat\tO\nhyperprolactinemia\tB-Disease\nspecifically\tO\naffects\tO\nTIDA\tO\nneurons\tO\nand\tO\nthese\tO\neffects\tO\nvary\tO\n,\tO\ndepending\tO\non\tO\nthe\tO\nduration\tO\nand\tO\nintensity\tO\nof\tO\nhyperprolactinemia\tB-Disease\n.\tO\n\nThe\tO\nage\tO\n-\tO\nrelated\tO\ndecrease\tO\nin\tO\nhypothalamic\tO\ndopamine\tB-Chemical\nfunction\tO\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nincreases\tO\nin\tO\nPRL\tO\nsecretion\tO\n.\tO\n\nTreatment\tO\n-\tO\nrelated\tO\ndisseminated\tO\nnecrotizing\tO\nleukoencephalopathy\tB-Disease\nwith\tO\ncharacteristic\tO\ncontrast\tO\nenhancement\tO\nof\tO\nthe\tO\nwhite\tO\nmatter\tO\n.\tO\n\nThis\tO\nreport\tO\ndescribes\tO\nunique\tO\ncontrast\tO\nenhancement\tO\nof\tO\nthe\tO\nwhite\tO\nmatter\tO\non\tO\nT1\tO\n-\tO\nweighted\tO\nmagnetic\tO\nresonance\tO\nimages\tO\nof\tO\ntwo\tO\npatients\tO\nwith\tO\ndisseminated\tO\nnecrotizing\tO\nleukoencephalopathy\tB-Disease\n,\tO\nwhich\tO\ndeveloped\tO\nfrom\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\ntreated\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\nmethotrexate\tB-Chemical\n.\tO\n\nIn\tO\nboth\tO\npatients\tO\n,\tO\nthe\tO\nenhancement\tO\nwas\tO\nmore\tO\npronounced\tO\nnear\tO\nthe\tO\nbase\tO\nof\tO\nthe\tO\nbrain\tO\nthan\tO\nat\tO\nthe\tO\nvertex\tO\n.\tO\n\nNecropsy\tO\nof\tO\nthe\tO\nfirst\tO\ncase\tO\nrevealed\tO\nloss\tB-Disease\nof\tI-Disease\nmyelination\tI-Disease\nand\tO\nnecrosis\tB-Disease\nof\tO\nthe\tO\nwhite\tO\nmatter\tO\n.\tO\n\nPossible\tO\nmechanisms\tO\ncausing\tO\nsuch\tO\na\tO\nleukoencephalopathy\tB-Disease\nare\tO\ndiscussed\tO\n.\tO\n\nThrombotic\tB-Disease\ncomplications\tO\nin\tO\nacute\tB-Disease\npromyelocytic\tI-Disease\nleukemia\tI-Disease\nduring\tO\nall\tB-Chemical\n-\tI-Chemical\ntrans\tI-Chemical\n-\tI-Chemical\nretinoic\tI-Chemical\nacid\tI-Chemical\ntherapy\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\ndue\tO\nto\tO\nocclusion\tB-Disease\nof\tI-Disease\nrenal\tI-Disease\nvessels\tI-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nacute\tB-Disease\npromyelocytic\tI-Disease\nleukemia\tI-Disease\n(\tO\nAPL\tB-Disease\n)\tO\ntreated\tO\nwith\tO\nall\tB-Chemical\n-\tI-Chemical\ntrans\tI-Chemical\n-\tI-Chemical\nretinoic\tI-Chemical\nacid\tI-Chemical\n(\tO\nATRA\tB-Chemical\n)\tO\nand\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\nhas\tO\nbeen\tO\ndescribed\tO\nrecently\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nin\tO\nan\tO\nAPL\tB-Disease\npatient\tO\ntreated\tO\nwith\tO\nATRA\tB-Chemical\nalone\tO\n.\tO\n\nThis\tO\ncase\tO\nfurther\tO\nsupports\tO\nthe\tO\nconcern\tO\nabout\tO\nthromboembolic\tB-Disease\ncomplications\tO\nassociated\tO\nwith\tO\nATRA\tB-Chemical\ntherapy\tO\nin\tO\nAPL\tB-Disease\npatients\tO\n.\tO\n\nThe\tO\npatients\tO\n,\tO\na\tO\n43\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\n,\tO\npresented\tO\nall\tO\nthe\tO\nsigns\tO\nand\tO\nsymptoms\tO\nof\tO\nAPL\tB-Disease\nand\tO\nwas\tO\nincluded\tO\nin\tO\na\tO\ntreatment\tO\nprotocol\tO\nwith\tO\nATRA\tB-Chemical\n.\tO\n\nAfter\tO\n10\tO\ndays\tO\nof\tO\ntreatment\tO\n,\tO\nhe\tO\ndeveloped\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nthat\tO\nwas\tO\ncompletely\tO\nreversible\tO\nafter\tO\ncomplete\tO\nremission\tO\nof\tO\nAPL\tB-Disease\nwas\tO\nachieved\tO\nand\tO\ntherapy\tO\ndiscontinued\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nATRA\tB-Chemical\nis\tO\na\tO\nvalid\tO\ntherapeutic\tO\nchoice\tO\nfor\tO\npatients\tO\nwith\tO\nAPL\tB-Disease\n,\tO\nalthough\tO\nthe\tO\nprocoagulant\tO\ntendency\tO\nis\tO\nnot\tO\ncompletely\tO\ncorrected\tO\n.\tO\n\nThrombotic\tB-Disease\nevents\tO\n,\tO\nhowever\tO\n,\tO\ncould\tO\nbe\tO\navoided\tO\nby\tO\nusing\tO\nlow\tO\n-\tO\ndose\tO\nheparin\tB-Chemical\n.\tO\n\nPupillary\tO\nchanges\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nstimulant\tO\n-\tO\ninduced\tO\nmania\tB-Disease\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nA\tO\n30\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tO\nman\tO\nwho\tO\nwas\tO\na\tO\nsubject\tO\nin\tO\na\tO\nstudy\tO\nevaluating\tO\nthe\tO\nanticraving\tO\nefficacy\tO\nof\tO\nthe\tO\nstimulant\tO\nmedication\tO\ndiethylpropion\tB-Chemical\n(\tO\nDEP\tB-Chemical\n)\tO\nbecame\tO\nmanic\tB-Disease\nduring\tO\nhis\tO\nsecond\tO\nweek\tO\non\tO\nthe\tO\nstudy\tO\ndrug\tO\n.\tO\n\nPupillometric\tO\nchanges\tO\nwhile\tO\non\tO\nDEP\tB-Chemical\n,\tO\nespecially\tO\nchanges\tO\nin\tO\nthe\tO\ntotal\tO\npower\tO\nof\tO\npupillary\tB-Disease\noscillation\tI-Disease\n,\tO\nwere\tO\ndramatically\tO\ndifferent\tO\nthan\tO\nthose\tO\nobserved\tO\nin\tO\nthe\tO\neight\tO\nother\tO\nstudy\tO\nsubjects\tO\nwho\tO\ndid\tO\nnot\tO\nbecome\tO\nmanic\tB-Disease\n.\tO\n\nThe\tO\nlarge\tO\nchanges\tO\nin\tO\ntotal\tO\npower\tO\nof\tO\npupillary\tB-Disease\noscillation\tI-Disease\noccurred\tO\na\tO\nfew\tO\ndays\tO\nbefore\tO\nthe\tO\npatient\tO\nbecame\tO\nfully\tO\nmanic\tB-Disease\n.\tO\n\nSuch\tO\nmedication\tO\n-\tO\nassociated\tO\nchanges\tO\nin\tO\nthe\tO\ntotal\tO\npower\tO\nof\tO\npupillary\tB-Disease\noscillation\tI-Disease\nmight\tO\nbe\tO\nof\tO\nutility\tO\nin\tO\nidentifying\tO\npersons\tO\nat\tO\nrisk\tO\nfor\tO\nmanic\tB-Disease\n-\tO\nlike\tO\nadverse\tO\neffects\tO\nduring\tO\nthe\tO\nmedical\tO\nuse\tO\nof\tO\npsychomotor\tO\nstimulants\tO\nor\tO\nsympathomimetic\tO\nagents\tO\n.\tO\n\nFetal\tO\nrisks\tO\ndue\tO\nto\tO\nwarfarin\tB-Chemical\ntherapy\tO\nduring\tO\npregnancy\tO\n.\tO\n\nTwo\tO\nmothers\tO\nwith\tO\nheart\tO\nvalve\tO\nprosthesis\tO\nwere\tO\ntreated\tO\nwith\tO\nwarfarin\tB-Chemical\nduring\tO\npregnancy\tO\n.\tO\n\nIn\tO\nthe\tO\nfirst\tO\ncase\tO\na\tO\ncaesarean\tO\nsection\tO\nwas\tO\ndone\tO\none\tO\nweek\tO\nafter\tO\nreplacement\tO\nof\tO\nwarfarin\tB-Chemical\nwith\tO\nheparin\tB-Chemical\n.\tO\n\nThe\tO\nbaby\tO\ndied\tO\nof\tO\ncerebral\tB-Disease\nand\tI-Disease\npulmonary\tI-Disease\nhemorrhage\tI-Disease\n.\tO\n\nThe\tO\nsecond\tO\nmother\tO\nhad\tO\na\tO\nmale\tO\ninfant\tO\nby\tO\ncaesarean\tO\nsection\tO\n.\tO\n\nThe\tO\nbaby\tO\nshowed\tO\nwarfarin\tB-Chemical\n-\tO\ninduced\tO\nembryopathy\tB-Disease\nwith\tO\nnasal\tB-Disease\nhypoplasia\tI-Disease\nand\tO\nstippled\tB-Disease\nepiphyses\tI-Disease\n(\tO\nchondrodysplasia\tB-Disease\npunctata\tI-Disease\n)\tO\n.\tO\n\nNasal\tB-Disease\nhypoplasia\tI-Disease\nwith\tO\nor\tO\nwithout\tO\nstippled\tB-Disease\nepiphyses\tI-Disease\nhas\tO\nnow\tO\nbeen\tO\nreported\tO\nin\tO\n11\tO\ninfants\tO\nborn\tO\nto\tO\nmothers\tO\ntreated\tO\nwith\tO\nwarfarin\tB-Chemical\nduring\tO\nthe\tO\nfirst\tO\ntrimester\tO\n,\tO\nand\tO\na\tO\ncausal\tO\nassociation\tO\nis\tO\nprobable\tO\n.\tO\n\nIn\tO\nview\tO\nof\tO\nthe\tO\nrisks\tO\nto\tO\nboth\tO\nmother\tO\nand\tO\nfetus\tO\nin\tO\nwomen\tO\nwith\tO\nprosthetic\tO\ncardiac\tO\nvalves\tO\nit\tO\nis\tO\nrecommended\tO\nthat\tO\ntherapeutic\tO\nabortion\tO\nbe\tO\nadvised\tO\nas\tO\nthe\tO\nfirst\tO\nalternative\tO\n.\tO\n\nThe\tO\nnegative\tO\nmucosal\tO\npotential\tO\n:\tO\nseparating\tO\ncentral\tO\nand\tO\nperipheral\tO\neffects\tO\nof\tO\nNSAIDs\tO\nin\tO\nman\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nWe\tO\nwanted\tO\nto\tO\ntest\tO\nwhether\tO\nassessment\tO\nof\tO\nboth\tO\na\tO\ncentral\tO\npain\tB-Disease\n-\tO\nrelated\tO\nsignal\tO\n(\tO\nchemo\tO\n-\tO\nsomatosensory\tO\nevoked\tO\npotential\tO\n,\tO\nCSSEP\tO\n)\tO\nand\tO\na\tO\nconcomitantly\tO\nrecorded\tO\nperipheral\tO\nsignal\tO\n(\tO\nnegative\tO\nmucosal\tO\npotential\tO\n,\tO\nNMP\tO\n)\tO\nallows\tO\nfor\tO\nseparation\tO\nof\tO\ncentral\tO\nand\tO\nperipheral\tO\neffects\tO\nof\tO\nNSAIDs\tO\n.\tO\n\nFor\tO\nthis\tO\npurpose\tO\n,\tO\nexperimental\tO\nconditions\tO\nwere\tO\ncreated\tO\nin\tO\nwhich\tO\nNSAIDs\tO\nhad\tO\npreviously\tO\nbeen\tO\nobserved\tO\nto\tO\nproduce\tO\neffects\tO\non\tO\nphasic\tO\nand\tO\ntonic\tO\npain\tB-Disease\nby\tO\neither\tO\ncentral\tO\nor\tO\nperipheral\tO\nmechanisms\tO\n.\tO\n\nMETHODS\tO\n:\tO\nAccording\tO\nto\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nrandomised\tO\n,\tO\ncontrolled\tO\n,\tO\nthreefold\tO\ncross\tO\n-\tO\nover\tO\ndesign\tO\n,\tO\n18\tO\nhealthy\tO\nsubjects\tO\n(\tO\n11\tO\nmales\tO\n,\tO\n7\tO\nfemales\tO\n;\tO\nmean\tO\nage\tO\n26\tO\nyears\tO\n)\tO\nreceived\tO\neither\tO\nplacebo\tO\n,\tO\n400\tO\nmg\tO\nibuprofen\tB-Chemical\n,\tO\nor\tO\n800\tO\nmg\tO\nibuprofen\tB-Chemical\n.\tO\n\nPhasic\tO\npain\tB-Disease\nwas\tO\napplied\tO\nby\tO\nmeans\tO\nof\tO\nshort\tO\npulses\tO\nof\tO\nCO2\tB-Chemical\nto\tO\nthe\tO\nnasal\tO\nmucosa\tO\n(\tO\nstimulus\tO\nduration\tO\n500\tO\nms\tO\n,\tO\ninterval\tO\napproximately\tO\n60\tO\ns\tO\n)\tO\n,\tO\nand\tO\ntonic\tO\npain\tB-Disease\nwas\tO\ninduced\tO\nin\tO\nthe\tO\nnasal\tO\ncavity\tO\nby\tO\nmeans\tO\nof\tO\ndry\tO\nair\tO\nof\tO\ncontrolled\tO\ntemperature\tO\n,\tO\nhumidity\tO\nand\tO\nflow\tO\nrate\tO\n(\tO\n22\tO\ndegrees\tO\nC\tO\n,\tO\n0\tO\n%\tO\nrelative\tO\nhumidity\tO\n,\tO\n145\tO\nml\tO\n.\tO\ns\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nBoth\tO\nCSSEPs\tO\nas\tO\ncentral\tO\nand\tO\nNMPs\tO\nas\tO\nperipheral\tO\ncorrelates\tO\nof\tO\npain\tB-Disease\nwere\tO\nobtained\tO\nin\tO\nresponse\tO\nto\tO\nthe\tO\nCO2\tB-Chemical\nstimuli\tO\n.\tO\n\nAdditionally\tO\n,\tO\nthe\tO\nsubjects\tO\nrated\tO\nthe\tO\nintensity\tO\nof\tO\nboth\tO\nphasic\tO\nand\tO\ntonic\tO\npain\tB-Disease\nby\tO\nmeans\tO\nof\tO\nvisual\tO\nanalogue\tO\nscales\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAs\tO\ndescribed\tO\nearlier\tO\n,\tO\nadministration\tO\nof\tO\nibuprofen\tB-Chemical\nwas\tO\nfollowed\tO\nby\tO\na\tO\ndecrease\tO\nin\tO\ntonic\tO\npain\tB-Disease\nbut\tO\n-\tO\nrelative\tO\nto\tO\nplacebo\tO\n-\tO\nan\tO\nincrease\tO\nin\tO\ncorrelates\tO\nof\tO\nphasic\tO\npain\tB-Disease\n,\tO\nindicating\tO\na\tO\nspecific\tO\neffect\tO\nof\tO\nibuprofen\tB-Chemical\non\tO\nthe\tO\ninteraction\tO\nbetween\tO\nthe\tO\npain\tB-Disease\nstimuli\tO\nunder\tO\nthese\tO\nspecial\tO\nexperimental\tO\nconditions\tO\n.\tO\n\nBased\tO\non\tO\nthe\tO\nsimilar\tO\nbehaviour\tO\nof\tO\nCSSEP\tO\nand\tO\nNMP\tO\n,\tO\nit\tO\nwas\tO\nconcluded\tO\nthat\tO\nthe\tO\npharmacological\tO\nprocess\tO\nunderlying\tO\nthis\tO\nphenomenon\tO\nwas\tO\nlocalised\tO\nin\tO\nthe\tO\nperiphery\tO\n.\tO\n\nBy\tO\nmeans\tO\nof\tO\nthe\tO\nsimultaneous\tO\nrecording\tO\nof\tO\ninterrelated\tO\nperipheral\tO\nand\tO\ncentral\tO\nelectrophysiologic\tO\ncorrelates\tO\nof\tO\nnociception\tO\n,\tO\nit\tO\nwas\tO\npossible\tO\nto\tO\nseparate\tO\ncentral\tO\nand\tO\nperipheral\tO\neffects\tO\nof\tO\nan\tO\nNSAID\tO\n.\tO\n\nThe\tO\nmajor\tO\nadvantage\tO\nof\tO\nthis\tO\npain\tB-Disease\nmodel\tO\nis\tO\nthe\tO\npossibility\tO\nof\tO\nobtaining\tO\nperipheral\tO\npain\tB-Disease\n-\tO\nrelated\tO\nactivity\tO\ndirectly\tO\nusing\tO\na\tO\nnon\tO\n-\tO\ninvasive\tO\ntechnique\tO\nin\tO\nhumans\tO\n.\tO\n\nEffect\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\nGlucarates\tI-Chemical\non\tO\nbasic\tO\nantibiotic\tO\n-\tO\ninduced\tO\nrenal\tB-Disease\ndamage\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nDehydrated\tB-Disease\nrats\tO\nregularly\tO\ndevelop\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nfollowing\tO\nsingle\tO\ninjection\tO\nof\tO\naminoglycoside\tB-Chemical\nantibiotics\tO\ncombined\tO\nwith\tO\ndextran\tO\nor\tO\nof\tO\nantibiotics\tO\nonly\tO\n.\tO\n\nOral\tO\nadministration\tO\nof\tO\n2\tB-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\ndi\tI-Chemical\n-\tI-Chemical\nO\tI-Chemical\n-\tI-Chemical\nacetyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\nglucaro\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n6\tI-Chemical\n,\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\ndilactone\tI-Chemical\nprotected\tO\nrats\tO\nagainst\tO\nrenal\tB-Disease\nfailure\tI-Disease\ninduced\tO\nby\tO\nkanamycin\tB-Chemical\n-\tO\ndextran\tO\n.\tO\n\nThe\tO\nprotective\tO\neffect\tO\nwas\tO\nprevalent\tO\namong\tO\nD\tB-Chemical\n-\tI-Chemical\nglucarates\tI-Chemical\n,\tO\nand\tO\nalso\tO\nto\tO\nother\tO\nsaccharic\tB-Chemical\nacid\tI-Chemical\n,\tO\nhexauronic\tB-Chemical\nacids\tI-Chemical\nand\tO\nhexaaldonic\tB-Chemical\nacids\tI-Chemical\n,\tO\nalthough\tO\nto\tO\na\tO\nlesser\tO\ndegree\tO\n,\tO\nbut\tO\nnot\tO\nto\tO\na\tO\nhexaaldose\tO\n,\tO\nsugar\tB-Chemical\nalcohols\tI-Chemical\n,\tO\nsubstances\tO\ninthe\tO\nTCA\tB-Chemical\ncycle\tO\nand\tO\nother\tO\nacidic\tO\ncompounds\tO\n.\tO\n\nD\tB-Chemical\n-\tI-Chemical\nGlucarates\tI-Chemical\nwere\tO\neffective\tO\nagainst\tO\nrenal\tB-Disease\ndamage\tI-Disease\ninduced\tO\nby\tO\npeptide\tO\nantibiotics\tO\nas\tO\nwell\tO\nas\tO\nvarious\tO\naminoglycoside\tB-Chemical\nantibitocis\tO\n.\tO\n\nDose\tO\n-\tO\nresponses\tO\nwere\tO\nobserved\tO\nin\tO\nthe\tO\nprotective\tO\neffect\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\nGlucarates\tI-Chemical\n.\tO\n\nWith\tO\na\tO\nD\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nof\tO\na\tO\nfixed\tO\nsize\tO\nof\tO\ndose\tO\n,\tO\napproximately\tO\nthe\tO\nsame\tO\ndegree\tO\nof\tO\nprotection\tO\nwas\tO\nobtained\tO\nagainst\tO\nrenal\tB-Disease\ndamages\tI-Disease\ninduced\tO\nby\tO\ndifferent\tO\nbasic\tO\nantibiotics\tO\ndespite\tO\nlarge\tO\ndisparities\tO\nin\tO\nadministration\tO\ndoses\tO\nof\tO\ndifferent\tO\nantibiotics\tO\n.\tO\n\nD\tB-Chemical\n-\tI-Chemical\nGlucarates\tI-Chemical\nhad\tO\nthe\tO\nability\tO\nto\tO\nprevent\tO\nrenal\tB-Disease\ndamage\tI-Disease\nbut\tO\nnot\tO\nto\tO\ncure\tO\nit\tO\n.\tO\n\nRats\tO\nexcreted\tO\nacidic\tO\nurine\tO\nwhen\tO\nthey\tO\nwere\tO\nspared\tO\nfrom\tO\nrenal\tB-Disease\nlesions\tI-Disease\nby\tO\nmonosaccharides\tB-Chemical\n.\tO\n\nThe\tO\nreduction\tO\neffect\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\nglucarates\tI-Chemical\nagainst\tO\nnephrotoxicity\tB-Disease\nof\tO\nbasic\tO\nantibiotics\tO\nwas\tO\ndiscussed\tO\n.\tO\n\nAcute\tO\nsevere\tO\ndepression\tB-Disease\nfollowing\tO\nperi\tO\n-\tO\noperative\tO\nondansetron\tB-Chemical\n.\tO\n\nA\tO\n41\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\na\tO\nstrong\tO\nhistory\tO\nof\tO\npostoperative\tB-Disease\nnausea\tI-Disease\nand\tI-Disease\nvomiting\tI-Disease\npresented\tO\nfor\tO\nabdominal\tO\nhysterectomy\tO\n3\tO\nmonths\tO\nafter\tO\na\tO\nprevious\tO\nanaesthetic\tO\nwhere\tO\nondansetron\tB-Chemical\nprophylaxis\tO\nhad\tO\nbeen\tO\nused\tO\n.\tO\n\nShe\tO\nhad\tO\ndeveloped\tO\na\tO\nsevere\tO\nacute\tO\nmajor\tB-Disease\ndepression\tI-Disease\ndisorder\tI-Disease\nalmost\tO\nimmediately\tO\nthereafter\tO\n,\tO\npossibly\tO\nrelated\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\na\tO\nserotonin\tB-Chemical\nantagonist\tO\n.\tO\n\nNine\tO\nyears\tO\nbefore\tO\nshe\tO\nhad\tO\nexperienced\tO\na\tO\nself\tO\n-\tO\nlimited\tO\npuerperal\tO\ndepressive\tB-Disease\nepisode\tI-Disease\n.\tO\n\nAnaesthesia\tO\nwith\tO\na\tO\npropofol\tB-Chemical\ninfusion\tO\nand\tO\navoidance\tO\nof\tO\nserotonin\tB-Chemical\nantagonists\tO\nprovided\tO\na\tO\nnausea\tB-Disease\n-\tO\nfree\tO\npostoperative\tO\ncourse\tO\nwithout\tO\nexacerbation\tO\nof\tO\nthe\tO\ndepression\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nHypertensive\tB-Disease\nresponse\tO\nduring\tO\ndobutamine\tB-Chemical\nstress\tO\nechocardiography\tO\n.\tO\n\nAmong\tO\n3\tO\n,\tO\n129\tO\ndobutamine\tB-Chemical\nstress\tO\nechocardiographic\tO\nstudies\tO\n,\tO\na\tO\nhypertensive\tB-Disease\nresponse\tO\n,\tO\ndefined\tO\nas\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\n>\tO\nor\tO\n=\tO\n220\tO\nmm\tO\nHg\tO\nand\tO\n/\tO\nor\tO\ndiastolic\tO\nBP\tO\n>\tO\nor\tO\n=\tO\n110\tO\nmm\tO\nHg\tO\n,\tO\noccurred\tO\nin\tO\n30\tO\npatients\tO\n(\tO\n1\tO\n%\tO\n)\tO\n.\tO\n\nPatients\tO\nwith\tO\nthis\tO\nresponse\tO\nmore\tO\noften\tO\nhad\tO\na\tO\nhistory\tO\nof\tO\nhypertension\tB-Disease\nand\tO\nhad\tO\nhigher\tO\nresting\tO\nsystolic\tO\nand\tO\ndiastolic\tO\nBP\tO\nbefore\tO\ndobutamine\tB-Chemical\ninfusion\tO\n.\tO\n\nContinuously\tO\nnebulized\tO\nalbuterol\tB-Chemical\nin\tO\nsevere\tO\nexacerbations\tO\nof\tO\nasthma\tB-Disease\nin\tO\nadults\tO\n:\tO\na\tO\ncase\tO\n-\tO\ncontrolled\tO\nstudy\tO\n.\tO\n\nA\tO\nretrospective\tO\n,\tO\ncase\tO\n-\tO\ncontrolled\tO\nanalysis\tO\ncomparing\tO\npatients\tO\nadmitted\tO\nto\tO\na\tO\nmedical\tO\nintensive\tO\ncare\tO\nunit\tO\nwith\tO\nsevere\tO\nexacerbations\tO\nof\tO\nasthma\tB-Disease\nwho\tO\nreceived\tO\ncontinuously\tO\nnebulized\tO\nalbuterol\tB-Chemical\n(\tO\nCNA\tO\n)\tO\nversus\tO\nintermittent\tO\nalbuterol\tB-Chemical\n(\tO\nINA\tO\n)\tO\ntreatments\tO\nis\tO\nreported\tO\n.\tO\n\nForty\tO\nmatched\tO\npairs\tO\nof\tO\npatients\tO\nwith\tO\nasthma\tB-Disease\nare\tO\ncompared\tO\n.\tO\n\nCNA\tO\nwas\tO\nadministered\tO\nfor\tO\na\tO\nmean\tO\nof\tO\n11\tO\n+\tO\n/\tO\n-\tO\n10\tO\nhr\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ncardiac\tB-Disease\ndysrhythmias\tI-Disease\nwas\tO\nsimilar\tO\nbetween\tO\ngroups\tO\n.\tO\n\nSymptomatic\tO\nhypokalemia\tB-Disease\ndid\tO\nnot\tO\noccur\tO\n.\tO\n\nCNA\tO\npatients\tO\nhad\tO\nhigher\tO\nheart\tO\nrates\tO\nduring\tO\ntreatment\tO\n,\tO\nwhich\tO\nmay\tO\nreflect\tO\nseverity\tO\nof\tO\nillness\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nintubation\tO\nwas\tO\nsimilar\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nCNA\tO\nand\tO\nINA\tO\ndemonstrated\tO\nsimilar\tO\nprofiles\tO\nwith\tO\nregard\tO\nto\tO\nsafety\tO\n,\tO\nmorbidity\tO\n,\tO\nand\tO\nmortality\tO\n.\tO\n\nParaplegia\tB-Disease\nfollowing\tO\nintrathecal\tO\nmethotrexate\tB-Chemical\n:\tO\nreport\tO\nof\tO\na\tO\ncase\tO\nand\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\n.\tO\n\nA\tO\npatient\tO\nwho\tO\ndeveloped\tO\nparaplegia\tB-Disease\nfollowing\tO\nthe\tO\nintrathecal\tO\ninstillation\tO\nof\tO\nmethotrexate\tB-Chemical\nis\tO\ndiscribed\tO\n.\tO\n\nThe\tO\nten\tO\npreviously\tO\nreported\tO\ncases\tO\nof\tO\nthis\tO\nunusual\tO\ncomplication\tO\nare\tO\nreviewed\tO\n.\tO\n\nThe\tO\nfollowing\tO\nfactors\tO\nappear\tO\nto\tO\npredispose\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\nthis\tO\ncomplication\tO\n:\tO\nabnormal\tO\ncerebrospinal\tO\ndynamics\tO\nrelated\tO\nto\tO\nthe\tO\npresence\tO\nof\tO\ncentral\tB-Disease\nnervous\tI-Disease\nsystem\tI-Disease\nleukemia\tI-Disease\n,\tO\nand\tO\nepidural\tO\ncerebrospinal\tO\nleakage\tO\n;\tO\nelevated\tO\ncerebrospinal\tO\nfluid\tO\nmethothexate\tB-Chemical\nconcentration\tO\nrelated\tO\nto\tO\nabnormal\tO\ncerebrospinal\tO\nfluid\tO\ndynamics\tO\nand\tO\nto\tO\ninappropriately\tO\nhigh\tO\nmethotrexate\tB-Chemical\ndoses\tO\nbased\tO\non\tO\nbody\tO\nsurface\tO\narea\tO\ncalculations\tO\nin\tO\nolder\tO\nchildren\tO\nand\tO\nadults\tO\n;\tO\nthe\tO\npresence\tO\nof\tO\nneurotoxic\tB-Disease\npreservatives\tO\nin\tO\ncommercially\tO\navailable\tO\nmethotrexate\tB-Chemical\npreparations\tO\nand\tO\ndiluents\tO\n;\tO\nand\tO\nthe\tO\nuse\tO\nof\tO\nmethotrexate\tB-Chemical\ndiluents\tO\nof\tO\nunphysiologic\tO\npH\tO\n,\tO\nionic\tO\ncontent\tO\nand\tO\nosmolarity\tO\n.\tO\n\nThe\tO\nrole\tO\nof\tO\nmethotrexate\tB-Chemical\ncontaminants\tO\n,\tO\nlocal\tO\nfolate\tB-Disease\ndeficiency\tI-Disease\n,\tO\nand\tO\ncranial\tO\nirradiation\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nintrathecal\tO\nmethotrexate\tB-Chemical\ntoxicity\tB-Disease\nis\tO\nunclear\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nneurotoxicity\tB-Disease\nmay\tO\nbe\tO\nreduced\tO\nby\tO\nemploying\tO\nlower\tO\ndoses\tO\nof\tO\nmethotrexate\tB-Chemical\nin\tO\nthe\tO\npresence\tO\nof\tO\ncentral\tB-Disease\nnervous\tI-Disease\nsystem\tI-Disease\nleukemia\tI-Disease\n,\tO\nin\tO\nolder\tO\nchildren\tO\nand\tO\nadults\tO\n,\tO\nand\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nepidural\tO\nleakage\tO\n.\tO\n\nOnly\tO\npreservative\tO\n-\tO\nfree\tO\nmethotrexate\tB-Chemical\nin\tO\nElliott\tO\n'\tO\ns\tO\nB\tO\nSolution\tO\nat\tO\na\tO\nconcentration\tO\nof\tO\nnot\tO\nmore\tO\nthan\tO\n1\tO\nmg\tO\n/\tO\nml\tO\nshould\tO\nbe\tO\nused\tO\nfor\tO\nintrathecal\tO\nadministration\tO\n.\tO\n\nPeriodic\tO\nmonitoring\tO\nof\tO\ncerebruspinal\tO\nfluid\tO\nmethotrexate\tB-Chemical\nlevels\tO\nmay\tO\nbe\tO\npredictive\tO\nof\tO\nthe\tO\ndevelopment\tO\nof\tO\nserious\tO\nneurotoxicity\tB-Disease\n.\tO\n\nHyperosmolar\tB-Disease\nnonketotic\tI-Disease\ncoma\tI-Disease\nprecipitated\tO\nby\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\n.\tO\n\nA\tO\n45\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\n,\tO\nwith\tO\na\tO\n10\tO\n-\tO\nyear\tO\nhistory\tO\nof\tO\nmanic\tB-Disease\ndepression\tI-Disease\ntreated\tO\nwith\tO\nlithium\tB-Chemical\n,\tO\nwas\tO\nadmitted\tO\nwith\tO\nhyperosmolar\tB-Disease\n,\tI-Disease\nnonketotic\tI-Disease\ncoma\tI-Disease\n.\tO\n\nHe\tO\ngave\tO\na\tO\nfive\tO\n-\tO\nyear\tO\nhistory\tO\nof\tO\npolyuria\tB-Disease\nand\tO\npolydipsia\tB-Disease\n,\tO\nduring\tO\nwhich\tO\ntime\tO\nurinalysis\tO\nhad\tO\nbeen\tO\nnegative\tO\nfor\tO\nglucose\tB-Chemical\n.\tO\n\nAfter\tO\nrecovery\tO\nfrom\tO\nhyperglycaemia\tB-Disease\n,\tO\nhe\tO\nremained\tO\npolyuric\tB-Disease\ndespite\tO\nnormal\tO\nblood\tO\nglucose\tB-Chemical\nconcentrations\tO\n;\tO\nwater\tO\ndeprivation\tO\ntesting\tO\nindicated\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\n,\tO\nlikely\tO\nto\tO\nbe\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\n.\tO\n\nWe\tO\nhypothesize\tO\nthat\tO\nwhen\tO\nthis\tO\nman\tO\ndeveloped\tO\ntype\tB-Disease\n2\tI-Disease\ndiabetes\tI-Disease\n,\tO\nchronic\tO\npolyuria\tB-Disease\ndue\tO\nto\tO\nnephrogenic\tB-Disease\ndiabetes\tI-Disease\ninsipidus\tI-Disease\nwas\tO\nsufficient\tO\nto\tO\nprecipitate\tO\nhyperosmolar\tO\ndehydration\tB-Disease\n.\tO\n\nEffects\tO\nof\tO\nthe\tO\nintracoronary\tO\ninfusion\tO\nof\tO\ncocaine\tB-Chemical\non\tO\nleft\tO\nventricular\tO\nsystolic\tO\nand\tO\ndiastolic\tO\nfunction\tO\nin\tO\nhumans\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIn\tO\ndogs\tO\n,\tO\na\tO\nlarge\tO\namount\tO\nof\tO\nintravenous\tO\ncocaine\tB-Chemical\ncauses\tO\na\tO\nprofound\tO\ndeterioration\tB-Disease\nof\tI-Disease\nleft\tI-Disease\nventricular\tI-Disease\n(\tI-Disease\nLV\tI-Disease\n)\tI-Disease\nsystolic\tI-Disease\nfunction\tI-Disease\nand\tO\nan\tO\nincrease\tO\nin\tO\nLV\tO\nend\tO\n-\tO\ndiastolic\tO\npressure\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\ndone\tO\nto\tO\nassess\tO\nthe\tO\ninfluence\tO\nof\tO\na\tO\nhigh\tO\nintracoronary\tO\ncocaine\tB-Chemical\nconcentration\tO\non\tO\nLV\tO\nsystolic\tO\nand\tO\ndiastolic\tO\nfunction\tO\nin\tO\nhumans\tO\n.\tO\n\nMETHODS\tO\nAND\tO\nRESULTS\tO\n:\tO\nIn\tO\n20\tO\npatients\tO\n(\tO\n14\tO\nmen\tO\nand\tO\n6\tO\nwomen\tO\naged\tO\n39\tO\nto\tO\n72\tO\nyears\tO\n)\tO\nreferred\tO\nfor\tO\ncardiac\tO\ncatheterization\tO\nfor\tO\nthe\tO\nevaluation\tO\nof\tO\nchest\tB-Disease\npain\tI-Disease\n,\tO\nwe\tO\nmeasured\tO\nheart\tO\nrate\tO\n,\tO\nsystemic\tO\narterial\tO\npressure\tO\n,\tO\nLV\tO\npressure\tO\nand\tO\nits\tO\nfirst\tO\nderivative\tO\n(\tO\ndP\tO\n/\tO\ndt\tO\n)\tO\n,\tO\nand\tO\nLV\tO\nvolumes\tO\nand\tO\nejection\tO\nfraction\tO\nbefore\tO\nand\tO\nduring\tO\nthe\tO\nfinal\tO\n2\tO\nto\tO\n3\tO\nminutes\tO\nof\tO\na\tO\n15\tO\n-\tO\nminute\tO\nintracoronary\tO\ninfusion\tO\nof\tO\nsaline\tO\n(\tO\nn\tO\n=\tO\n10\tO\n,\tO\ncontrol\tO\nsubjects\tO\n)\tO\nor\tO\ncocaine\tB-Chemical\nhydrochloride\tI-Chemical\n1\tO\nmg\tO\n/\tO\nmin\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\n.\tO\n\nNo\tO\nvariable\tO\nchanged\tO\nwith\tO\nsaline\tO\n.\tO\n\nWith\tO\ncocaine\tB-Chemical\n,\tO\nthe\tO\ndrug\tO\nconcentration\tO\nin\tO\nblood\tO\nobtained\tO\nfrom\tO\nthe\tO\ncoronary\tO\nsinus\tO\nwas\tO\n3\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n4\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nmg\tO\n/\tO\nL\tO\n,\tO\nsimilar\tO\nin\tO\nmagnitude\tO\nto\tO\nthe\tO\nblood\tO\ncocaine\tB-Chemical\nconcentration\tO\nreported\tO\nin\tO\nabusers\tO\ndying\tO\nof\tO\ncocaine\tB-Chemical\nintoxication\tO\n.\tO\n\nCocaine\tB-Chemical\ninduced\tO\nno\tO\nsignificant\tO\nchange\tO\nin\tO\nheart\tO\nrate\tO\n,\tO\nLV\tO\ndP\tO\n/\tO\ndt\tO\n(\tO\npositive\tO\nor\tO\nnegative\tO\n)\tO\n,\tO\nor\tO\nLV\tO\nend\tO\n-\tO\ndiastolic\tO\nvolume\tO\n,\tO\nbut\tO\nit\tO\ncaused\tO\nan\tO\nincrease\tO\nin\tO\nsystolic\tO\nand\tO\nmean\tO\narterial\tO\npressures\tO\n,\tO\nLV\tO\nend\tO\n-\tO\ndiastolic\tO\npressure\tO\n,\tO\nand\tO\nLV\tO\nend\tO\n-\tO\nsystolic\tO\nvolume\tO\n,\tO\nas\tO\nwell\tO\nas\tO\na\tO\ndecrease\tO\nin\tO\nLV\tO\nejection\tO\nfraction\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\nhumans\tO\n,\tO\nthe\tO\nintracoronary\tO\ninfusion\tO\nof\tO\ncocaine\tB-Chemical\nsufficient\tO\nin\tO\namount\tO\nto\tO\nachieve\tO\na\tO\nhigh\tO\ndrug\tO\nconcentration\tO\nin\tO\ncoronary\tO\nsinus\tO\nblood\tO\ncauses\tO\na\tO\ndeterioration\tB-Disease\nof\tI-Disease\nLV\tI-Disease\nsystolic\tI-Disease\nand\tI-Disease\ndiastolic\tI-Disease\nperformance\tI-Disease\n.\tO\n\nAscending\tO\ndose\tO\ntolerance\tO\nstudy\tO\nof\tO\nintramuscular\tO\ncarbetocin\tB-Chemical\nadministered\tO\nafter\tO\nnormal\tO\nvaginal\tO\nbirth\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nmaximum\tO\ntolerated\tO\ndose\tO\n(\tO\nMTD\tO\n)\tO\nof\tO\ncarbetocin\tB-Chemical\n(\tO\na\tO\nlong\tO\n-\tO\nacting\tO\nsynthetic\tO\nanalogue\tO\nof\tO\noxytocin\tB-Chemical\n)\tO\n,\tO\nwhen\tO\nadministered\tO\nimmediately\tO\nafter\tO\nvaginal\tO\ndelivery\tO\nat\tO\nterm\tO\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nCarbetocin\tB-Chemical\nwas\tO\ngiven\tO\nas\tO\nan\tO\nintramuscular\tO\ninjection\tO\nimmediately\tO\nafter\tO\nthe\tO\nbirth\tO\nof\tO\nthe\tO\ninfant\tO\nin\tO\n45\tO\nhealthy\tO\nwomen\tO\nwith\tO\nnormal\tO\nsingleton\tO\npregnancies\tO\nwho\tO\ndelivered\tO\nvaginally\tO\nat\tO\nterm\tO\n.\tO\n\nDosage\tO\ngroups\tO\nof\tO\n15\tO\n,\tO\n30\tO\n,\tO\n50\tO\n,\tO\n75\tO\n,\tO\n100\tO\n,\tO\n125\tO\n,\tO\n150\tO\n,\tO\n175\tO\nor\tO\n200\tO\nmicrog\tO\ncarbetocin\tB-Chemical\nwere\tO\nassigned\tO\nto\tO\nblocks\tO\nof\tO\nthree\tO\nwomen\tO\naccording\tO\nto\tO\nthe\tO\ncontinual\tO\nreassessment\tO\nmethod\tO\n(\tO\nCRM\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\ndosage\tO\ngroups\tO\nconsisted\tO\nof\tO\nthree\tO\nwomen\tO\n,\tO\nexcept\tO\nthose\tO\nwith\tO\n100\tO\nmicrog\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nand\tO\n200\tO\nmicrog\tO\n(\tO\nn\tO\n=\tO\n18\tO\n)\tO\n.\tO\n\nRecorded\tO\nwere\tO\ndose\tO\n-\tO\nlimiting\tO\nadverse\tO\nevents\tO\n:\tO\nhyper\tB-Disease\n-\tI-Disease\nor\tI-Disease\nhypotension\tI-Disease\n(\tO\nthree\tO\n)\tO\n,\tO\nsevere\tO\nabdominal\tB-Disease\npain\tI-Disease\n(\tO\n0\tO\n)\tO\n,\tO\nvomiting\tB-Disease\n(\tO\n0\tO\n)\tO\nand\tO\nretained\tB-Disease\nplacenta\tI-Disease\n(\tO\nfour\tO\n)\tO\n.\tO\n\nSerious\tO\nadverse\tO\nevents\tO\noccurred\tO\nin\tO\nseven\tO\nwomen\tO\n:\tO\nsix\tO\ncases\tO\nwith\tO\nblood\tB-Disease\nloss\tI-Disease\n>\tO\nor\tO\n=\tO\n1000\tO\nml\tO\n,\tO\nfour\tO\ncases\tO\nof\tO\nmanual\tO\nplacenta\tO\nremoval\tO\n,\tO\nfive\tO\ncases\tO\nof\tO\nadditional\tO\noxytocics\tO\nadministration\tO\nand\tO\nfive\tO\ncases\tO\nof\tO\nblood\tO\ntransfusion\tO\n.\tO\n\nMaximum\tO\nblood\tB-Disease\nloss\tI-Disease\nwas\tO\ngreatest\tO\nat\tO\nthe\tO\nupper\tO\nand\tO\nlower\tO\ndose\tO\nlevels\tO\n,\tO\nand\tO\nlowest\tO\nin\tO\nthe\tO\n70\tO\n-\tO\n125\tO\nmicrog\tO\ndose\tO\nrange\tO\n.\tO\n\nFour\tO\nout\tO\nof\tO\nsix\tO\ncases\tO\nwith\tO\nblood\tB-Disease\nloss\tI-Disease\n>\tO\nor\tO\n=\tO\n1000\tO\nml\tO\noccurred\tO\nin\tO\nthe\tO\n200\tO\nmicrog\tO\ngroup\tO\n.\tO\n\nThe\tO\nmajority\tO\nof\tO\nadditional\tO\nadministration\tO\nof\tO\noxytocics\tO\n(\tO\n4\tO\n/\tO\n5\tO\n)\tO\nand\tO\nblood\tO\ntransfusion\tO\n(\tO\n3\tO\n/\tO\n5\tO\n)\tO\noccurred\tO\nin\tO\nthe\tO\ndose\tO\ngroups\tO\nof\tO\n200\tO\nmicrog\tO\n.\tO\n\nAll\tO\nretained\tO\nplacentae\tO\nwere\tO\nfound\tO\nin\tO\nthe\tO\ngroup\tO\nof\tO\n200\tO\nmicrog\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nMTD\tO\nwas\tO\ncalculated\tO\nto\tO\nbe\tO\nat\tO\n200\tO\nmicrog\tO\ncarbetocin\tB-Chemical\n.\tO\n\nHeparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n,\tO\nparadoxical\tO\nthromboembolism\tB-Disease\n,\tO\nand\tO\nother\tO\nside\tO\neffects\tO\nof\tO\nheparin\tB-Chemical\ntherapy\tO\n.\tO\n\nAlthough\tO\nseveral\tO\nnew\tO\nanticoagulant\tO\ndrugs\tO\nare\tO\nin\tO\ndevelopment\tO\n,\tO\nheparin\tB-Chemical\nremains\tO\nthe\tO\ndrug\tO\nof\tO\nchoice\tO\nfor\tO\nmost\tO\nanticoagulation\tO\nneeds\tO\n.\tO\n\nThe\tO\nclinical\tO\neffects\tO\nof\tO\nheparin\tB-Chemical\nare\tO\nmeritorious\tO\n,\tO\nbut\tO\nside\tO\neffects\tO\ndo\tO\nexist\tO\n.\tO\n\nImportant\tO\nuntoward\tO\neffects\tO\nof\tO\nheparin\tB-Chemical\ntherapy\tO\nincluding\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n,\tO\nheparin\tB-Chemical\n-\tO\nassociated\tO\nosteoporosis\tB-Disease\n,\tO\neosinophilia\tB-Disease\n,\tO\nskin\tB-Disease\nreactions\tI-Disease\n,\tO\nallergic\tB-Disease\nreactions\tI-Disease\nother\tO\nthan\tO\nthrombocytopenia\tB-Disease\nand\tO\nalopecia\tB-Disease\nwill\tO\nbe\tO\ndiscussed\tO\nin\tO\nthis\tO\narticle\tO\n.\tO\n\nNonopaque\tO\ncrystal\tO\ndeposition\tO\ncausing\tO\nureteric\tB-Disease\nobstruction\tI-Disease\nin\tO\npatients\tO\nwith\tO\nHIV\tO\nundergoing\tO\nindinavir\tB-Chemical\ntherapy\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nWe\tO\ndescribe\tO\nthe\tO\nunique\tO\nCT\tO\nfeatures\tO\nof\tO\nureteric\tB-Disease\ncalculi\tI-Disease\nin\tO\nsix\tO\nHIV\tB-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\nreceiving\tO\nindinavir\tB-Chemical\n,\tO\nthe\tO\nmost\tO\ncommonly\tO\nused\tO\nHIV\tO\nprotease\tO\ninhibitor\tO\n,\tO\nwhich\tO\nis\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nincidence\tO\nof\tO\nurolithiasis\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nUreteric\tB-Disease\nobstruction\tI-Disease\ncaused\tO\nby\tO\nprecipitated\tO\nindinavir\tB-Chemical\ncrystals\tO\nmay\tO\nbe\tO\ndifficult\tO\nto\tO\ndiagnose\tO\nwith\tO\nunenhanced\tO\nCT\tO\n.\tO\n\nThe\tO\ncalculi\tO\nare\tO\nnot\tO\nopaque\tO\n,\tO\nand\tO\nsecondary\tO\nsigns\tO\nof\tO\nobstruction\tO\nmay\tO\nbe\tO\nabsent\tO\nor\tO\nminimal\tO\nand\tO\nshould\tO\nbe\tO\nsought\tO\ncarefully\tO\n.\tO\n\nImages\tO\nmay\tO\nneed\tO\nto\tO\nbe\tO\nobtained\tO\nusing\tO\ni\tO\n.\tO\nv\tO\n.\tO\ncontrast\tO\nmaterial\tO\nto\tO\nenable\tO\ndiagnosis\tO\nof\tO\nureteric\tB-Disease\nstones\tI-Disease\nor\tI-Disease\nobstruction\tI-Disease\nin\tO\npatients\tO\nwith\tO\nHIV\tB-Disease\ninfection\tI-Disease\nwho\tO\nreceive\tO\nindinavir\tB-Chemical\ntherapy\tO\n.\tO\n\nIschemic\tB-Disease\ncolitis\tI-Disease\nand\tO\nsumatriptan\tB-Chemical\nuse\tO\n.\tO\n\nSumatriptan\tB-Chemical\nsuccinate\tI-Chemical\n,\tO\na\tO\nserotonin\tB-Chemical\n-\tO\n1\tO\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptamine\tI-Chemical\n-\tO\n1\tO\n)\tO\nreceptor\tO\nagonist\tO\n,\tO\nis\tO\nan\tO\nantimigraine\tO\ndrug\tO\nthat\tO\nis\tO\nreported\tO\nto\tO\nact\tO\nby\tO\nselectively\tO\nconstricting\tO\nintracranial\tO\narteries\tO\n.\tO\n\nRecently\tO\n,\tO\nvasopressor\tO\nresponses\tO\nthat\tO\nare\tO\ndistinct\tO\nfrom\tO\nthe\tO\ncranial\tO\ncirculation\tO\nhave\tO\nbeen\tO\ndemonstrated\tO\nto\tO\noccur\tO\nin\tO\nthe\tO\nsystemic\tO\n,\tO\npulmonary\tO\n,\tO\nand\tO\ncoronary\tO\ncirculations\tO\n.\tO\n\nCases\tO\nhave\tO\nbeen\tO\npublished\tO\nof\tO\ncoronary\tB-Disease\nvasospasm\tI-Disease\n,\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n,\tO\nand\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\noccurring\tO\nafter\tO\nsumatriptan\tB-Chemical\nuse\tO\n.\tO\n\nWe\tO\nreport\tO\non\tO\nthe\tO\ndevelopment\tO\nof\tO\n8\tO\nserious\tO\ncases\tO\nof\tO\nischemic\tB-Disease\ncolitis\tI-Disease\nin\tO\npatients\tO\nwith\tO\nmigraine\tB-Disease\ntreated\tO\nwith\tO\nsumatriptan\tB-Chemical\n.\tO\n\nPallidotomy\tO\nwith\tO\nthe\tO\ngamma\tO\nknife\tO\n:\tO\na\tO\npositive\tO\nexperience\tO\n.\tO\n\n51\tO\npatients\tO\nwith\tO\nmedically\tO\nrefractory\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nunderwent\tO\nstereotactic\tO\nposteromedial\tO\npallidotomy\tO\nbetween\tO\nAugust\tO\n1993\tO\nand\tO\nFebruary\tO\n1997\tO\nfor\tO\ntreatment\tO\nof\tO\nbradykinesia\tB-Disease\n,\tO\nrigidity\tB-Disease\n,\tO\nand\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n.\tO\n\nIn\tO\n29\tO\npatients\tO\n,\tO\nthe\tO\npallidotomies\tO\nwere\tO\nperformed\tO\nwith\tO\nthe\tO\nLeksell\tO\nGamma\tO\nKnife\tO\nand\tO\nin\tO\n22\tO\nthey\tO\nwere\tO\nperformed\tO\nwith\tO\nthe\tO\nstandard\tO\nradiofrequency\tO\n(\tO\nRF\tO\n)\tO\nmethod\tO\n.\tO\n\nClinical\tO\nassessment\tO\nas\tO\nwell\tO\nas\tO\nblinded\tO\nratings\tO\nof\tO\nUnified\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nRating\tO\nScale\tO\n(\tO\nUPDRS\tO\n)\tO\nscores\tO\nwere\tO\ncarried\tO\nout\tO\npre\tO\n-\tO\nand\tO\npostoperatively\tO\n.\tO\n\nMean\tO\nfollow\tO\n-\tO\nup\tO\ntime\tO\nis\tO\n20\tO\n.\tO\n6\tO\nmonths\tO\n(\tO\nrange\tO\n6\tO\n-\tO\n48\tO\n)\tO\nand\tO\nall\tO\nexcept\tO\n4\tO\npatients\tO\nhave\tO\nbeen\tO\nfollowed\tO\nmore\tO\nthan\tO\none\tO\nyear\tO\n.\tO\n\n85\tO\npercent\tO\nof\tO\npatients\tO\nwith\tO\ndyskinesias\tB-Disease\nwere\tO\nrelieved\tO\nof\tO\nsymptoms\tO\n,\tO\nregardless\tO\nof\tO\nwhether\tO\nthe\tO\npallidotomies\tO\nwere\tO\nperformed\tO\nwith\tO\nthe\tO\nGamma\tO\nKnife\tO\nor\tO\nradiofrequency\tO\nmethods\tO\n.\tO\n\nAbout\tO\n2\tO\n/\tO\n3\tO\nof\tO\nthe\tO\npatients\tO\nin\tO\nboth\tO\nGamma\tO\nKnife\tO\nand\tO\nradiofrequency\tO\ngroups\tO\nshowed\tO\nimprovements\tO\nin\tO\nbradykinesia\tB-Disease\nand\tO\nrigidity\tB-Disease\n,\tO\nalthough\tO\nwhen\tO\nconsidered\tO\nas\tO\na\tO\ngroup\tO\nneither\tO\nthe\tO\nGamma\tO\nKnife\tO\nnor\tO\nthe\tO\nradiofrequency\tO\ngroup\tO\nshowed\tO\nstatistically\tO\nsignificant\tO\nimprovements\tO\nin\tO\nUPDRS\tO\nscores\tO\n.\tO\n\nOne\tO\npatient\tO\nin\tO\nthe\tO\nGamma\tO\nKnife\tO\ngroup\tO\n(\tO\n3\tO\n.\tO\n4\tO\n%\tO\n)\tO\ndeveloped\tO\na\tO\nhomonymous\tB-Disease\nhemianopsia\tI-Disease\n9\tO\nmonths\tO\nfollowing\tO\ntreatment\tO\nand\tO\n5\tO\npatients\tO\n(\tO\n27\tO\n.\tO\n7\tO\n%\tO\n)\tO\nin\tO\nthe\tO\nradiofrequency\tO\ngroup\tO\nbecame\tO\ntransiently\tO\nconfused\tO\npostoperatively\tO\n.\tO\n\nNo\tO\nother\tO\ncomplications\tO\nwere\tO\nseen\tO\n.\tO\n\nGamma\tO\nKnife\tO\npallidotomy\tO\nis\tO\nas\tO\neffective\tO\nas\tO\nradiofrequency\tO\npallidotomy\tO\nin\tO\ncontrolling\tO\ncertain\tO\nof\tO\nthe\tO\nsymptoms\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nIt\tO\nmay\tO\nbe\tO\nthe\tO\nonly\tO\npractical\tO\ntechnique\tO\navailable\tO\nin\tO\ncertain\tO\npatients\tO\n,\tO\nsuch\tO\nas\tO\nthose\tO\nwho\tO\ntake\tO\nanticoagulants\tO\n,\tO\nhave\tO\nbleeding\tB-Disease\ndiatheses\tO\nor\tO\nserious\tO\nsystemic\tO\nmedical\tO\nillnesses\tO\n.\tO\n\nIt\tO\nis\tO\na\tO\nviable\tO\noption\tO\nfor\tO\nother\tO\npatients\tO\nas\tO\nwell\tO\n.\tO\n\nCentrally\tO\nmediated\tO\ncardiovascular\tO\neffects\tO\nof\tO\nintracisternal\tO\napplication\tO\nof\tO\ncarbachol\tB-Chemical\nin\tO\nanesthetized\tO\nrats\tO\n.\tO\n\nThe\tO\npressor\tO\nresponse\tO\nto\tO\nthe\tO\nintracisternal\tO\n(\tO\ni\tO\n.\tO\nc\tO\n.\tO\n)\tO\ninjection\tO\nof\tO\ncarbachol\tB-Chemical\n(\tO\n1\tO\nmug\tO\n)\tO\nin\tO\nanesthetized\tO\nrats\tO\nwas\tO\nanalyzed\tO\n.\tO\n\nThis\tO\nresponse\tO\nwas\tO\nsignificantly\tO\nreduced\tO\nby\tO\nthe\tO\nintravenous\tO\n(\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\ninjection\tO\nof\tO\nguanethidine\tB-Chemical\n(\tO\n5\tO\nmg\tO\n)\tO\n,\tO\nhexamethonium\tB-Chemical\n(\tO\n10\tO\nmg\tO\n)\tO\nor\tO\nphentolamine\tB-Chemical\n(\tO\n5\tO\nmg\tO\n)\tO\n,\tO\nand\tO\nconversely\tO\n,\tO\npotentiated\tO\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\ndesmethylimipramine\tB-Chemical\n(\tO\n0\tO\n.\tO\n3\tO\nmg\tO\n)\tO\n,\tO\nwhile\tO\npropranolol\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n)\tO\ni\tO\n.\tO\nv\tO\n.\tO\nselectively\tO\ninhibited\tO\nthe\tO\nenlargement\tB-Disease\nof\tI-Disease\npulse\tI-Disease\npressure\tI-Disease\nand\tO\nthe\tO\ntachycardia\tB-Disease\nfollowing\tO\ni\tO\n.\tO\nc\tO\n.\tO\ncarbachol\tB-Chemical\n(\tO\n1\tO\nmug\tO\n)\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nthe\tO\npressor\tO\nresponse\tO\nto\tO\ni\tO\n.\tO\nc\tO\n.\tO\ncarbachol\tB-Chemical\n(\tO\n1\tO\nmug\tO\n)\tO\nwas\tO\nalmost\tO\ncompletely\tO\nblocked\tO\nby\tO\ni\tO\n.\tO\nc\tO\n.\tO\natropine\tB-Chemical\n(\tO\n3\tO\nmug\tO\n)\tO\nor\tO\nhexamethonium\tB-Chemical\n(\tO\n500\tO\nmug\tO\n)\tO\n,\tO\nand\tO\nsignificantly\tO\nreduced\tO\nby\tO\ni\tO\n.\tO\nc\tO\n.\tO\nchlorpromazine\tB-Chemical\n(\tO\n50\tO\nmug\tO\n)\tO\nbut\tO\nsignificantly\tO\npotentiated\tO\nby\tO\ni\tO\n.\tO\nc\tO\n.\tO\ndesmethylimipramine\tB-Chemical\n(\tO\n30\tO\nmug\tO\n)\tO\n.\tO\n\nThe\tO\npressor\tO\nresponse\tO\nto\tO\ni\tO\n.\tO\nc\tO\n.\tO\ncarbachol\tB-Chemical\n(\tO\n1\tO\nmug\tO\n)\tO\nremained\tO\nunchanged\tO\nafter\tO\nsectioning\tO\nof\tO\nthe\tO\nbilateral\tO\ncervical\tO\nvagal\tO\nnerves\tO\nbut\tO\ndisappeared\tO\nafter\tO\nsectioning\tO\nof\tO\nthe\tO\nspinal\tO\ncord\tO\n(\tO\nC7\tO\n-\tO\nC8\tO\n)\tO\n.\tO\n\nFrom\tO\nthe\tO\nabove\tO\nresult\tO\nit\tO\nis\tO\nsuggested\tO\nthat\tO\nthe\tO\npressor\tO\nresponse\tO\nto\tO\ni\tO\n.\tO\nc\tO\n.\tO\ncarbachol\tB-Chemical\nortral\tO\nand\tO\nperipheral\tO\nadrenergic\tO\nmechanisms\tO\n,\tO\nand\tO\nthat\tO\nthe\tO\nsympathetic\tO\ntrunk\tO\nis\tO\nthe\tO\nmain\tO\npathway\tO\n.\tO\n\nNeuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nand\tO\nmethylphenidate\tB-Chemical\n.\tO\n\nA\tO\n1\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfemale\tO\npresented\tO\nwith\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nprobably\tO\ncaused\tO\nby\tO\nmethylphenidate\tB-Chemical\n.\tO\n\nShe\tO\nhad\tO\ndefects\tO\nin\tO\nthe\tO\nsupratentorial\tO\nbrain\tO\nincluding\tO\nthe\tO\nbasal\tO\nganglia\tO\nand\tO\nthe\tO\nstriatum\tO\n(\tO\nmulticystic\tB-Disease\nencephalomalacia\tI-Disease\n)\tO\ndue\tO\nto\tO\nsevere\tO\nperinatal\tO\nhypoxic\tB-Disease\n-\tI-Disease\nischemic\tI-Disease\nencephalopathy\tI-Disease\n,\tO\nwhich\tO\nwas\tO\nconsidered\tO\nto\tO\nbe\tO\na\tO\npossible\tO\npredisposing\tO\nfactor\tO\ncausing\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nA\tO\ndopaminergic\tO\nblockade\tO\nmechanism\tO\ngenerally\tO\nis\tO\naccepted\tO\nas\tO\nthe\tO\npathogenesis\tO\nof\tO\nthis\tO\nsyndrome\tO\n.\tO\n\nHowever\tO\n,\tO\nmethylphenidate\tB-Chemical\nis\tO\na\tO\ndopamine\tB-Chemical\nagonist\tO\nvia\tO\nthe\tO\ninhibition\tO\nof\tO\nuptake\tO\nof\tO\ndopamine\tB-Chemical\n,\tO\nand\tO\ntherefore\tO\ndopaminergic\tO\nsystems\tO\nin\tO\nthe\tO\nbrainstem\tO\n(\tO\nmainly\tO\nthe\tO\nmidbrain\tO\n)\tO\nand\tO\nthe\tO\nspinal\tO\ncord\tO\nwere\tO\nunlikely\tO\nto\tO\nparticipate\tO\nin\tO\nthe\tO\nonset\tO\nof\tO\nthis\tO\nsyndrome\tO\n.\tO\n\nA\tO\nrelative\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n-\tO\nergic\tO\ndeficiency\tO\nmight\tO\noccur\tO\nbecause\tO\ndiazepam\tB-Chemical\n,\tO\na\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n-\tO\nmimetic\tO\nagent\tO\n,\tO\nwas\tO\nstrikingly\tO\neffective\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nreported\tO\npatient\tO\nwith\tO\nneuroleptic\tB-Disease\nmalignant\tI-Disease\nsyndrome\tI-Disease\nprobably\tO\ncaused\tO\nby\tO\nmethylphenidate\tB-Chemical\n.\tO\n\nDifferential\tO\neffects\tO\nof\tO\n17alpha\tB-Chemical\n-\tI-Chemical\nethinylestradiol\tI-Chemical\non\tO\nthe\tO\nneutral\tO\nand\tO\nacidic\tO\npathways\tO\nof\tO\nbile\tB-Chemical\nsalt\tI-Chemical\nsynthesis\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nEffects\tO\nof\tO\n17alpha\tB-Chemical\n-\tI-Chemical\nethinylestradiol\tI-Chemical\n(\tO\nEE\tB-Chemical\n)\tO\non\tO\nthe\tO\nneutral\tO\nand\tO\nacidic\tO\nbiosynthetic\tO\npathways\tO\nof\tO\nbile\tB-Chemical\nsalt\tI-Chemical\n(\tO\nBS\tB-Chemical\n)\tO\nsynthesis\tO\nwere\tO\nevaluated\tO\nin\tO\nrats\tO\nwith\tO\nan\tO\nintact\tO\nenterohepatic\tO\ncirculation\tO\nand\tO\nin\tO\nrats\tO\nwith\tO\nlong\tO\n-\tO\nterm\tO\nbile\tO\ndiversion\tO\nto\tO\ninduce\tO\nBS\tB-Chemical\nsynthesis\tO\n.\tO\n\nFor\tO\nthis\tO\npurpose\tO\n,\tO\nbile\tB-Chemical\nsalt\tI-Chemical\npool\tO\ncomposition\tO\n,\tO\nsynthesis\tO\nof\tO\nindividual\tO\nBS\tB-Chemical\nin\tO\nvivo\tO\n,\tO\nhepatic\tO\nactivities\tO\n,\tO\nand\tO\nexpression\tO\nlevels\tO\nof\tO\ncholesterol\tB-Chemical\n7alpha\tO\n-\tO\nhydroxylase\tO\n(\tO\nCYP7A\tO\n)\tO\n,\tO\nand\tO\nsterol\tB-Chemical\n27\tO\n-\tO\nhydroxylase\tO\n(\tO\nCYP27\tO\n)\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nof\tO\nother\tO\nenzymes\tO\ninvolved\tO\nin\tO\nBS\tB-Chemical\nsynthesis\tO\n,\tO\nwere\tO\nanalyzed\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\nEE\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\n3\tO\ndays\tO\n)\tO\nor\tO\nits\tO\nvehicle\tO\n.\tO\n\nBS\tB-Chemical\npool\tO\nsize\tO\nwas\tO\ndecreased\tO\nby\tO\n27\tO\n%\tO\nbut\tO\ntotal\tO\nBS\tB-Chemical\nsynthesis\tO\nwas\tO\nnot\tO\naffected\tO\nby\tO\nEE\tB-Chemical\nin\tO\nintact\tO\nrats\tO\n.\tO\n\nSynthesis\tO\nof\tO\ncholate\tB-Chemical\nwas\tO\nreduced\tO\nby\tO\n68\tO\n%\tO\nin\tO\nEE\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n,\tO\nwhile\tO\nthat\tO\nof\tO\nchenodeoxycholate\tB-Chemical\nwas\tO\nincreased\tO\nby\tO\n60\tO\n%\tO\n.\tO\n\nThe\tO\nrecently\tO\nidentified\tO\nDelta22\tO\n-\tO\nisomer\tO\nof\tO\nbeta\tO\n-\tO\nmuricholate\tO\ncontributed\tO\nfor\tO\n5\tO\n.\tO\n4\tO\n%\tO\nand\tO\n18\tO\n.\tO\n3\tO\n%\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nto\tO\nthe\tO\npool\tO\nin\tO\ncontrol\tO\nand\tO\nEE\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n,\tO\nrespectively\tO\n,\tO\nbut\tO\ncould\tO\nnot\tO\nbe\tO\ndetected\tO\nin\tO\nbile\tO\nafter\tO\nexhaustion\tO\nof\tO\nthe\tO\npool\tO\n.\tO\n\nA\tO\nclear\tO\nreduction\tO\nof\tO\nBS\tB-Chemical\nsynthesis\tO\nwas\tO\nfound\tO\nin\tO\nbile\tO\n-\tO\ndiverted\tO\nrats\tO\ntreated\tO\nwith\tO\nEE\tB-Chemical\n,\tO\nyet\tO\nbiliary\tO\nBS\tB-Chemical\ncomposition\tO\nwas\tO\nonly\tO\nminimally\tO\naffected\tO\n.\tO\n\nActivity\tO\nof\tO\nCYP7A\tO\nwas\tO\ndecreased\tO\nby\tO\nEE\tB-Chemical\nin\tO\nboth\tO\nintact\tO\nand\tO\nbile\tO\n-\tO\ndiverted\tO\nrats\tO\n,\tO\nwhereas\tO\nthe\tO\nactivity\tO\nof\tO\nthe\tO\nCYP27\tO\nwas\tO\nnot\tO\naffected\tO\n.\tO\n\nHepatic\tO\nmRNA\tO\nlevels\tO\nof\tO\nCYP7A\tO\nwere\tO\nsignificantly\tO\nreduced\tO\nby\tO\nEE\tB-Chemical\nin\tO\nbile\tO\n-\tO\ndiverted\tO\nrats\tO\nonly\tO\n;\tO\nCYP27\tO\nmRNA\tO\nlevels\tO\nwere\tO\nnot\tO\naffected\tO\nby\tO\nEE\tB-Chemical\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nmRNA\tO\nlevels\tO\nof\tO\nsterol\tB-Chemical\n12alpha\tO\n-\tO\nhydroxylase\tO\nand\tO\nlithocholate\tO\n6beta\tO\n-\tO\nhydroxylase\tO\nwere\tO\nincreased\tO\nby\tO\nbile\tO\ndiversion\tO\nand\tO\nsuppressed\tO\nby\tO\nEE\tB-Chemical\n.\tO\n\nThis\tO\nstudy\tO\nshows\tO\nthat\tO\n17alpha\tB-Chemical\n-\tI-Chemical\nethinylestradiol\tI-Chemical\n(\tO\nEE\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nintrahepatic\tB-Disease\ncholestasis\tI-Disease\nin\tO\nrats\tO\nis\tO\nassociated\tO\nwith\tO\nselective\tO\ninhibition\tO\nof\tO\nthe\tO\nneutral\tO\npathway\tO\nof\tO\nbile\tB-Chemical\nsalt\tI-Chemical\n(\tO\nBS\tB-Chemical\n)\tO\nsynthesis\tO\n.\tO\n\nSimultaneous\tO\nimpairment\tO\nof\tO\nother\tO\nenzymes\tO\nin\tO\nthe\tO\nBS\tB-Chemical\nbiosynthetic\tO\npathways\tO\nmay\tO\ncontribute\tO\nto\tO\noverall\tO\neffects\tO\nof\tO\nEE\tB-Chemical\non\tO\nBS\tB-Chemical\nsynthesis\tO\n.\tO\n\nGlibenclamide\tB-Chemical\n-\tO\nsensitive\tO\nhypotension\tB-Disease\nproduced\tO\nby\tO\nhelodermin\tB-Chemical\nassessed\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nhelodermin\tB-Chemical\n,\tO\na\tO\nbasic\tO\n35\tO\n-\tO\namino\tB-Chemical\nacid\tI-Chemical\npeptide\tO\nisolated\tO\nfrom\tO\nthe\tO\nvenom\tO\nof\tO\na\tO\nlizard\tO\nsalivary\tO\ngland\tO\n,\tO\non\tO\narterial\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\nwere\tO\nexamined\tO\nin\tO\nthe\tO\nrat\tO\n,\tO\nfocusing\tO\non\tO\nthe\tO\npossibility\tO\nthat\tO\nactivation\tO\nof\tO\nATP\tB-Chemical\nsensitive\tO\nK\tB-Chemical\n+\tO\n(\tO\nK\tB-Chemical\n(\tO\nATP\tB-Chemical\n)\tO\n)\tO\nchannels\tO\nis\tO\ninvolved\tO\nin\tO\nthe\tO\nresponses\tO\n.\tO\n\nThe\tO\nresults\tO\nwere\tO\nalso\tO\ncompared\tO\nwith\tO\nthose\tO\nof\tO\nvasoactive\tO\nintestinal\tO\npolypeptide\tO\n(\tO\nVIP\tO\n)\tO\n.\tO\n\nHelodermin\tB-Chemical\nproduced\tO\nhypotension\tB-Disease\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\nwith\tO\napproximately\tO\nsimilar\tO\npotency\tO\nand\tO\nduration\tO\nto\tO\nVIP\tO\n.\tO\n\nHypotension\tB-Disease\ninduced\tO\nby\tO\nboth\tO\npeptides\tO\nwas\tO\nsignificantly\tO\nattenuated\tO\nby\tO\nglibenclamide\tB-Chemical\n,\tO\nwhich\tO\nabolished\tO\na\tO\nlevcromakalim\tB-Chemical\n-\tO\nproduced\tO\ndecrease\tO\nin\tO\narterial\tO\nblood\tO\npressure\tO\n.\tO\n\nOxyhemoglobin\tO\ndid\tO\nnot\tO\naffect\tO\nhelodermin\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\n,\tO\nwhereas\tO\nit\tO\nshortened\tO\nthe\tO\nduration\tO\nof\tO\nacetylcholine\tB-Chemical\n(\tO\nACh\tB-Chemical\n)\tO\n-\tO\nproduced\tO\nhypotension\tB-Disease\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nhelodermin\tB-Chemical\n-\tO\nproduced\tO\nhypotension\tB-Disease\nis\tO\npartly\tO\nattributable\tO\nto\tO\nthe\tO\nactivation\tO\nof\tO\nglibenclamide\tB-Chemical\n-\tO\nsensitive\tO\nK\tB-Chemical\n+\tO\nchannels\tO\n(\tO\nK\tB-Chemical\n(\tO\nATP\tB-Chemical\n)\tO\nchannels\tO\n)\tO\n,\tO\nwhich\tO\npresumably\tO\nexist\tO\non\tO\narterial\tO\nsmooth\tO\nmuscle\tO\ncells\tO\n.\tO\n\nEDRF\tO\n(\tO\nendothelium\tO\n-\tO\nderived\tO\nrelaxing\tO\nfactor\tO\n)\tO\n/\tO\nnitric\tB-Chemical\noxide\tI-Chemical\ndoes\tO\nnot\tO\nseem\tO\nto\tO\nplay\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\npeptide\tO\n-\tO\nproduced\tO\nhypotension\tB-Disease\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nefficacy\tO\nand\tO\nadverse\tO\nevent\tO\nof\tO\nnifedipine\tB-Chemical\nsustained\tO\n-\tO\nrelease\tO\ntablets\tO\nfor\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\npatients\tO\nwith\tO\npsoriasis\tB-Disease\n.\tO\n\nThirteen\tO\npsoriatic\tB-Disease\npatients\tO\nwith\tO\nhypertension\tB-Disease\nduring\tO\nthe\tO\ncourse\tO\nof\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\ntherapy\tO\nwere\tO\ntreated\tO\nfor\tO\n25\tO\nmonths\tO\nwith\tO\na\tO\ncalcium\tB-Chemical\nchannel\tO\nblocker\tO\n,\tO\nsustained\tO\n-\tO\nrelease\tO\nnifedipine\tB-Chemical\n,\tO\nto\tO\nstudy\tO\nthe\tO\nclinical\tO\nantihypertensive\tO\neffects\tO\nand\tO\nadverse\tO\nevents\tO\nduring\tO\ntreatment\tO\nwith\tO\nboth\tO\ndrugs\tO\n.\tO\n\nSeven\tO\nof\tO\nthe\tO\n13\tO\npatients\tO\nhad\tO\nexhibited\tO\na\tO\nsubclinical\tO\nhypertensive\tB-Disease\nstate\tO\nbefore\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\ntherapy\tO\n.\tO\n\nBoth\tO\nsystolic\tO\nand\tO\ndiastolic\tO\nblood\tO\npressures\tO\nof\tO\nthese\tO\n13\tO\npatients\tO\nwere\tO\ndecreased\tO\nsignificantly\tO\nafter\tO\n4\tO\nweeks\tO\nof\tO\nnifedipine\tB-Chemical\ntherapy\tO\n,\tO\nand\tO\nblood\tO\npressure\tO\nwas\tO\nmaintained\tO\nwithin\tO\nthe\tO\nnormal\tO\nrange\tO\nthereafter\tO\nfor\tO\n25\tO\nmonths\tO\n.\tO\n\nThe\tO\nadverse\tO\nevents\tO\nduring\tO\ncombined\tO\ntherapy\tO\nwith\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\nand\tO\nnifedipine\tB-Chemical\nincluded\tO\nan\tO\nincrease\tO\nin\tO\nblood\tB-Chemical\nurea\tI-Chemical\nnitrogen\tI-Chemical\nlevels\tO\nin\tO\n9\tO\nof\tO\nthe\tO\n13\tO\npatients\tO\nand\tO\ndevelopment\tO\nof\tO\ngingival\tB-Disease\nhyperplasia\tI-Disease\nin\tO\n2\tO\nof\tO\nthe\tO\n13\tO\npatients\tO\n.\tO\n\nOur\tO\nfindings\tO\nindicate\tO\nthat\tO\nsustained\tO\n-\tO\nrelease\tO\nnifedipine\tB-Chemical\nis\tO\nuseful\tO\nfor\tO\nhypertensive\tB-Disease\npsoriatic\tB-Disease\npatients\tO\nunder\tO\nlong\tO\n-\tO\nterm\tO\ntreatment\tO\nwith\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\n,\tO\nbut\tO\nthat\tO\nthese\tO\npatients\tO\nshould\tO\nbe\tO\nmonitored\tO\nfor\tO\ngingival\tB-Disease\nhyperplasia\tI-Disease\n.\tO\n\n"
  },
  {
    "path": "dataset/BC5CDR/train.txt",
    "content": "Selegiline\tB-Chemical\n-\tO\ninduced\tO\npostural\tB-Disease\nhypotension\tI-Disease\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n:\tO\na\tO\nlongitudinal\tO\nstudy\tO\non\tO\nthe\tO\neffects\tO\nof\tO\ndrug\tO\nwithdrawal\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nUnited\tO\nKingdom\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nResearch\tO\nGroup\tO\n(\tO\nUKPDRG\tO\n)\tO\ntrial\tO\nfound\tO\nan\tO\nincreased\tO\nmortality\tO\nin\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tO\nmg\tO\nselegiline\tB-Chemical\nper\tO\nday\tO\nand\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\ncompared\tO\nwith\tO\nthose\tO\ntaking\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nalone\tO\n.\tO\n\nRecently\tO\n,\tO\nwe\tO\nfound\tO\nthat\tO\ntherapy\tO\nwith\tO\nselegiline\tB-Chemical\nand\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nwas\tO\nassociated\tO\nwith\tO\nselective\tO\nsystolic\tB-Disease\northostatic\tI-Disease\nhypotension\tI-Disease\nwhich\tO\nwas\tO\nabolished\tO\nby\tO\nwithdrawal\tO\nof\tO\nselegiline\tB-Chemical\n.\tO\n\nThis\tO\nunwanted\tO\neffect\tO\non\tO\npostural\tO\nblood\tO\npressure\tO\nwas\tO\nnot\tO\nthe\tO\nresult\tO\nof\tO\nunderlying\tO\nautonomic\tO\nfailure\tO\n.\tO\n\nThe\tO\naims\tO\nof\tO\nthis\tO\nstudy\tO\nwere\tO\nto\tO\nconfirm\tO\nour\tO\nprevious\tO\nfindings\tO\nin\tO\na\tO\nseparate\tO\ncohort\tO\nof\tO\npatients\tO\nand\tO\nto\tO\ndetermine\tO\nthe\tO\ntime\tO\ncourse\tO\nof\tO\nthe\tO\ncardiovascular\tO\nconsequences\tO\nof\tO\nstopping\tO\nselegiline\tB-Chemical\nin\tO\nthe\tO\nexpectation\tO\nthat\tO\nthis\tO\nmight\tO\nshed\tO\nlight\tO\non\tO\nthe\tO\nmechanisms\tO\nby\tO\nwhich\tO\nthe\tO\ndrug\tO\ncauses\tO\northostatic\tB-Disease\nhypotension\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\ncardiovascular\tO\nresponses\tO\nto\tO\nstanding\tO\nand\tO\nhead\tO\n-\tO\nup\tO\ntilt\tO\nwere\tO\nstudied\tO\nrepeatedly\tO\nin\tO\nPD\tB-Disease\npatients\tO\nreceiving\tO\nselegiline\tB-Chemical\nand\tO\nas\tO\nthe\tO\ndrug\tO\nwas\tO\nwithdrawn\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHead\tO\n-\tO\nup\tO\ntilt\tO\ncaused\tO\nsystolic\tB-Disease\northostatic\tI-Disease\nhypotension\tI-Disease\nwhich\tO\nwas\tO\nmarked\tO\nin\tO\nsix\tO\nof\tO\n20\tO\nPD\tB-Disease\npatients\tO\non\tO\nselegiline\tB-Chemical\n,\tO\none\tO\nof\tO\nwhom\tO\nlost\tO\nconsciousness\tO\nwith\tO\nunrecordable\tO\nblood\tO\npressures\tO\n.\tO\n\nA\tO\nlesser\tO\ndegree\tO\nof\tO\northostatic\tB-Disease\nhypotension\tI-Disease\noccurred\tO\nwith\tO\nstanding\tO\n.\tO\n\nOrthostatic\tB-Disease\nhypotension\tI-Disease\nwas\tO\nameliorated\tO\n4\tO\ndays\tO\nafter\tO\nwithdrawal\tO\nof\tO\nselegiline\tB-Chemical\nand\tO\ntotally\tO\nabolished\tO\n7\tO\ndays\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nStopping\tO\nselegiline\tB-Chemical\nalso\tO\nsignificantly\tO\nreduced\tB-Disease\nthe\tI-Disease\nsupine\tI-Disease\nsystolic\tI-Disease\nand\tI-Disease\ndiastolic\tI-Disease\nblood\tI-Disease\npressures\tI-Disease\nconsistent\tO\nwith\tO\na\tO\npreviously\tO\nundescribed\tO\nsupine\tO\npressor\tO\naction\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nstudy\tO\nconfirms\tO\nour\tO\nprevious\tO\nfinding\tO\nthat\tO\nselegiline\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nis\tO\nassociated\tO\nwith\tO\nselective\tO\northostatic\tB-Disease\nhypotension\tI-Disease\n.\tO\n\nThe\tO\npossibilities\tO\nthat\tO\nthese\tO\ncardiovascular\tO\nfindings\tO\nmight\tO\nbe\tO\nthe\tO\nresult\tO\nof\tO\nnon\tO\n-\tO\nselective\tO\ninhibition\tO\nof\tO\nmonoamine\tO\noxidase\tO\nor\tO\nof\tO\namphetamine\tB-Chemical\nand\tO\nmetamphetamine\tB-Chemical\nare\tO\ndiscussed\tO\n.\tO\n\nFurther\tO\nstudies\tO\non\tO\neffects\tO\nof\tO\nirrigation\tO\nsolutions\tO\non\tO\nrat\tO\nbladders\tO\n.\tO\n\nFurther\tO\nstudies\tO\non\tO\nthe\tO\neffects\tO\nof\tO\ncertain\tO\nirrigating\tO\nfluids\tO\non\tO\nthe\tO\nrat\tO\nbladder\tO\nfor\tO\n18\tO\nhours\tO\nare\tO\nreported\tO\n.\tO\n\nThe\tO\nresults\tO\nhave\tO\nshown\tO\nthat\tO\nthe\tO\ndegradation\tO\nproduct\tO\np\tB-Chemical\n-\tI-Chemical\ncholoroaniline\tI-Chemical\nis\tO\nnot\tO\na\tO\nsignificant\tO\nfactor\tO\nin\tO\nchlorhexidine\tB-Chemical\n-\tI-Chemical\ndigluconate\tI-Chemical\nassociated\tO\nerosive\tO\ncystitis\tB-Disease\n.\tO\n\nA\tO\nhigh\tO\npercentage\tO\nof\tO\nkanamycin\tB-Chemical\n-\tO\ncolistin\tB-Chemical\nand\tO\npovidone\tB-Chemical\n-\tI-Chemical\niodine\tI-Chemical\nirrigations\tO\nwere\tO\nassociated\tO\nwith\tO\nerosive\tO\ncystitis\tB-Disease\nand\tO\nsuggested\tO\na\tO\npossible\tO\ncomplication\tO\nwith\tO\nhuman\tO\nusage\tO\n.\tO\n\nPicloxydine\tB-Chemical\nirrigations\tO\nappeared\tO\nto\tO\nhave\tO\na\tO\nlower\tO\nincidence\tO\nof\tO\nerosive\tO\ncystitis\tB-Disease\nbut\tO\nfurther\tO\nstudies\tO\nwould\tO\nhave\tO\nto\tO\nbe\tO\nperformed\tO\nbefore\tO\nit\tO\ncould\tO\nbe\tO\nrecommended\tO\nfor\tO\nuse\tO\nin\tO\nurological\tO\nprocedures\tO\n.\tO\n\nEffects\tO\nof\tO\ntetrandrine\tB-Chemical\nand\tO\nfangchinoline\tB-Chemical\non\tO\nexperimental\tO\nthrombosis\tB-Disease\nin\tO\nmice\tO\nand\tO\nhuman\tO\nplatelet\tB-Disease\naggregation\tI-Disease\n.\tO\n\nTetrandrine\tB-Chemical\n(\tO\nTET\tB-Chemical\n)\tO\nand\tO\nfangchinoline\tB-Chemical\n(\tO\nFAN\tB-Chemical\n)\tO\nare\tO\ntwo\tO\nnaturally\tO\noccurring\tO\nanalogues\tO\nwith\tO\na\tO\nbisbenzylisoquinoline\tB-Chemical\nstructure\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\nTET\tB-Chemical\nand\tO\nFAN\tB-Chemical\non\tO\nthe\tO\nexperimental\tO\nthrombosis\tB-Disease\ninduced\tO\nby\tO\ncollagen\tO\nplus\tO\nepinephrine\tB-Chemical\n(\tO\nEP\tB-Chemical\n)\tO\nin\tO\nmice\tO\n,\tO\nand\tO\nplatelet\tB-Disease\naggregation\tI-Disease\nand\tO\nblood\tB-Disease\ncoagulation\tI-Disease\nin\tO\nvitro\tO\n.\tO\n\nIn\tO\nthe\tO\nin\tO\nvivo\tO\nstudy\tO\n,\tO\nthe\tO\nadministration\tO\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nof\tO\nTET\tB-Chemical\nand\tO\nFAN\tB-Chemical\nin\tO\nmice\tO\nshowed\tO\nthe\tO\ninhibition\tO\nof\tO\nthrombosis\tB-Disease\nby\tO\n55\tO\n%\tO\nand\tO\n35\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nwhile\tO\nacetylsalicylic\tB-Chemical\nacid\tI-Chemical\n(\tO\nASA\tB-Chemical\n,\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\na\tO\npositive\tO\ncontrol\tO\n,\tO\nshowed\tO\nonly\tO\n30\tO\n%\tO\ninhibition\tO\n.\tO\n\nIn\tO\nthe\tO\nvitro\tO\nhuman\tO\nplatelet\tB-Disease\naggregations\tI-Disease\ninduced\tO\nby\tO\nthe\tO\nagonists\tO\nused\tO\nin\tO\ntests\tO\n,\tO\nTET\tB-Chemical\nand\tO\nFAN\tB-Chemical\nshowed\tO\nthe\tO\ninhibitions\tO\ndose\tO\ndependently\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nneither\tO\nTET\tB-Chemical\nnor\tO\nFAN\tB-Chemical\nshowed\tO\nany\tO\nanticoagulation\tO\nactivities\tO\nin\tO\nthe\tO\nmeasurement\tO\nof\tO\nthe\tO\nactivated\tO\npartial\tO\nthromboplastin\tO\ntime\tO\n(\tO\nAPTT\tO\n)\tO\n,\tO\nprothrombin\tO\ntime\tO\n(\tO\nPT\tO\n)\tO\nand\tO\nthrombin\tO\ntime\tO\n(\tO\nTT\tO\n)\tO\nusing\tO\nhuman\tO\n-\tO\ncitrated\tO\nplasma\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nantithrombosis\tO\nof\tO\nTET\tB-Chemical\nand\tO\nFAN\tB-Chemical\nin\tO\nmice\tO\nmay\tO\nbe\tO\nmainly\tO\nrelated\tO\nto\tO\nthe\tO\nantiplatelet\tO\naggregation\tO\nactivities\tO\n.\tO\n\nAngioedema\tB-Disease\ndue\tO\nto\tO\nACE\tB-Chemical\ninhibitors\tI-Chemical\n:\tO\ncommon\tO\nand\tO\ninadequately\tO\ndiagnosed\tO\n.\tO\n\nThe\tO\nestimated\tO\nincidence\tO\nof\tO\nangioedema\tB-Disease\nduring\tO\nangiotensin\tB-Chemical\n-\tI-Chemical\nconverting\tI-Chemical\nenzyme\tI-Chemical\n(\tI-Chemical\nACE\tI-Chemical\n)\tI-Chemical\ninhibitor\tI-Chemical\ntreatment\tO\nis\tO\nbetween\tO\n1\tO\nand\tO\n7\tO\nper\tO\nthousand\tO\npatients\tO\n.\tO\n\nThis\tO\npotentially\tO\nserious\tO\nadverse\tO\neffect\tO\nis\tO\noften\tO\npreceded\tO\nby\tO\nminor\tO\nmanifestations\tO\nthat\tO\nmay\tO\nserve\tO\nas\tO\na\tO\nwarning\tO\n.\tO\n\nCocaine\tB-Chemical\n-\tO\ninduced\tO\nmood\tB-Disease\ndisorder\tI-Disease\n:\tO\nprevalence\tO\nrates\tO\nand\tO\npsychiatric\tB-Disease\nsymptoms\tO\nin\tO\nan\tO\noutpatient\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tO\nsample\tO\n.\tO\n\nThis\tO\npaper\tO\nattempts\tO\nto\tO\nexamine\tO\nand\tO\ncompare\tO\nprevalence\tO\nrates\tO\nand\tO\nsymptom\tO\npatterns\tO\nof\tO\nDSM\tO\nsubstance\tO\n-\tO\ninduced\tO\nand\tO\nother\tO\nmood\tB-Disease\ndisorders\tI-Disease\n.\tO\n\n243\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tO\noutpatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nmood\tB-Disease\ndisorder\tI-Disease\n(\tO\nCIMD\tB-Disease\n)\tO\n,\tO\nother\tO\nmood\tB-Disease\ndisorders\tI-Disease\n,\tO\nor\tO\nno\tO\nmood\tB-Disease\ndisorder\tI-Disease\nwere\tO\ncompared\tO\non\tO\nmeasures\tO\nof\tO\npsychiatric\tB-Disease\nsymptoms\tO\n.\tO\n\nThe\tO\nprevalence\tO\nrate\tO\nfor\tO\nCIMD\tB-Disease\nwas\tO\n12\tO\n%\tO\nat\tO\nbaseline\tO\n.\tO\n\nIntroduction\tO\nof\tO\nthe\tO\nDSM\tO\n-\tO\nIV\tO\ndiagnosis\tO\nof\tO\nCIMD\tB-Disease\ndid\tO\nnot\tO\nsubstantially\tO\naffect\tO\nrates\tO\nof\tO\nthe\tO\nother\tO\ndepressive\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nPatients\tO\nwith\tO\nCIMD\tB-Disease\nhad\tO\nsymptom\tO\nseverity\tO\nlevels\tO\nbetween\tO\nthose\tO\nof\tO\npatients\tO\nwith\tO\nand\tO\nwithout\tO\na\tO\nmood\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nsome\tO\nvalidity\tO\nfor\tO\nthe\tO\nnew\tO\nDSM\tO\n-\tO\nIV\tO\ndiagnosis\tO\nof\tO\nCIMD\tB-Disease\n,\tO\nbut\tO\nalso\tO\nsuggest\tO\nthat\tO\nit\tO\nrequires\tO\nfurther\tO\nspecification\tO\nand\tO\nreplication\tO\n.\tO\n\nEffect\tO\nof\tO\nfucoidan\tB-Chemical\ntreatment\tO\non\tO\ncollagenase\tO\n-\tO\ninduced\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nInflammatory\tO\ncells\tO\nare\tO\npostulated\tO\nto\tO\nmediate\tO\nsome\tO\nof\tO\nthe\tO\nbrain\tB-Disease\ndamage\tI-Disease\nfollowing\tO\nischemic\tB-Disease\nstroke\tI-Disease\n.\tO\n\nIntracerebral\tB-Disease\nhemorrhage\tI-Disease\nis\tO\nassociated\tO\nwith\tO\nmore\tO\ninflammation\tB-Disease\nthan\tO\nischemic\tB-Disease\nstroke\tI-Disease\n.\tO\n\nWe\tO\ntested\tO\nthe\tO\nsulfated\tO\npolysaccharide\tO\nfucoidan\tB-Chemical\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nreduce\tO\ninflammatory\tO\nbrain\tB-Disease\ndamage\tI-Disease\n,\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\ninduced\tO\nby\tO\ninjection\tO\nof\tO\nbacterial\tO\ncollagenase\tO\ninto\tO\nthe\tO\ncaudate\tO\nnucleus\tO\n.\tO\n\nRats\tO\nwere\tO\ntreated\tO\nwith\tO\nseven\tO\nday\tO\nintravenous\tO\ninfusion\tO\nof\tO\nfucoidan\tB-Chemical\n(\tO\n30\tO\nmicrograms\tO\nh\tO\n-\tO\n1\tO\n)\tO\nor\tO\nvehicle\tO\n.\tO\n\nThe\tO\nhematoma\tB-Disease\nwas\tO\nassessed\tO\nin\tO\nvivo\tO\nby\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n.\tO\n\nMotor\tO\nbehavior\tO\n,\tO\npassive\tO\navoidance\tO\n,\tO\nand\tO\nskilled\tO\nforelimb\tO\nfunction\tO\nwere\tO\ntested\tO\nrepeatedly\tO\nfor\tO\nsix\tO\nweeks\tO\n.\tO\n\nFucoidan\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nexhibited\tO\nevidence\tO\nof\tO\nimpaired\tB-Disease\nblood\tI-Disease\nclotting\tI-Disease\nand\tO\nhemodilution\tB-Disease\n,\tO\nhad\tO\nlarger\tO\nhematomas\tB-Disease\n,\tO\nand\tO\ntended\tO\nto\tO\nhave\tO\nless\tO\ninflammation\tB-Disease\nin\tO\nthe\tO\nvicinity\tO\nof\tO\nthe\tO\nhematoma\tB-Disease\nafter\tO\nthree\tO\ndays\tO\n.\tO\n\nThey\tO\nshowed\tO\nsignificantly\tO\nmore\tO\nrapid\tO\nimprovement\tO\nof\tO\nmotor\tO\nfunction\tO\nin\tO\nthe\tO\nfirst\tO\nweek\tO\nfollowing\tO\nhemorrhage\tB-Disease\nand\tO\nbetter\tO\nmemory\tO\nretention\tO\nin\tO\nthe\tO\npassive\tO\navoidance\tO\ntest\tO\n.\tO\n\nAcute\tO\nwhite\tB-Disease\nmatter\tI-Disease\nedema\tI-Disease\nand\tO\neventual\tO\nneuronal\tB-Disease\nloss\tI-Disease\nin\tO\nthe\tO\nstriatum\tO\nadjacent\tO\nto\tO\nthe\tO\nhematoma\tB-Disease\ndid\tO\nnot\tO\ndiffer\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nInvestigation\tO\nof\tO\nmore\tO\nspecific\tO\nanti\tO\n-\tO\ninflammatory\tO\nagents\tO\nand\tO\nhemodiluting\tO\nagents\tO\nare\tO\nwarranted\tO\nin\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n.\tO\n\nRecurarization\tO\nin\tO\nthe\tO\nrecovery\tO\nroom\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nrecurarization\tO\nin\tO\nthe\tO\nrecovery\tO\nroom\tO\nis\tO\nreported\tO\n.\tO\n\nAccumulation\tO\nof\tO\natracurium\tB-Chemical\nin\tO\nthe\tO\nintravenous\tO\nline\tO\nled\tO\nto\tO\nrecurarization\tO\nafter\tO\nflushing\tO\nthe\tO\nline\tO\nin\tO\nthe\tO\nrecovery\tO\nroom\tO\n.\tO\n\nA\tO\nrespiratory\tB-Disease\narrest\tI-Disease\nwith\tO\nsevere\tO\ndesaturation\tB-Disease\nand\tO\nbradycardia\tB-Disease\noccurred\tO\n.\tO\n\nCircumstances\tO\nleading\tO\nto\tO\nthis\tO\nevent\tO\nand\tO\nthe\tO\nmechanisms\tO\nenabling\tO\na\tO\nneuromuscular\tB-Disease\nblockade\tI-Disease\nto\tO\noccur\tO\n,\tO\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\na\tO\nsmall\tO\ndose\tO\nof\tO\nrelaxant\tO\n,\tO\nare\tO\ndiscussed\tO\n.\tO\n\nThe\tO\nhaemodynamic\tO\neffects\tO\nof\tO\npropofol\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nephedrine\tB-Chemical\nin\tO\nelderly\tO\npatients\tO\n(\tO\nASA\tO\ngroups\tO\n3\tO\nand\tO\n4\tO\n)\tO\n.\tO\n\nThe\tO\nmarked\tO\nvasodilator\tO\nand\tO\nnegative\tO\ninotropic\tO\neffects\tO\nof\tO\npropofol\tB-Chemical\nare\tO\ndisadvantages\tO\nin\tO\nfrail\tO\nelderly\tO\npatients\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nadding\tO\ndifferent\tO\ndoses\tO\nof\tO\nephedrine\tB-Chemical\nto\tO\npropofol\tB-Chemical\nin\tO\norder\tO\nto\tO\nobtund\tO\nthe\tO\nhypotensive\tB-Disease\nresponse\tO\n.\tO\n\nThe\tO\nhaemodynamic\tO\neffects\tO\nof\tO\nadding\tO\n15\tO\n,\tO\n20\tO\nor\tO\n25\tO\nmg\tO\nof\tO\nephedrine\tB-Chemical\nto\tO\n200\tO\nmg\tO\nof\tO\npropofol\tB-Chemical\nwere\tO\ncompared\tO\nto\tO\ncontrol\tO\nin\tO\n40\tO\nASA\tO\n3\tO\n/\tO\n4\tO\npatients\tO\nover\tO\n60\tO\nyears\tO\npresenting\tO\nfor\tO\ngenito\tO\n-\tO\nurinary\tO\nsurgery\tO\n.\tO\n\nThe\tO\naddition\tO\nof\tO\nephedrine\tB-Chemical\nto\tO\npropofol\tB-Chemical\nappears\tO\nto\tO\nbe\tO\nan\tO\neffective\tO\nmethod\tO\nof\tO\nobtunding\tO\nthe\tO\nhypotensive\tB-Disease\nresponse\tO\nto\tO\npropofol\tB-Chemical\nat\tO\nall\tO\ndoses\tO\nused\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nHowever\tO\n,\tO\nmarked\tO\ntachycardia\tB-Disease\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nephedrine\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\npropofol\tB-Chemical\noccurred\tO\nin\tO\nthe\tO\nmajority\tO\nof\tO\npatients\tO\n,\tO\noccasionally\tO\nreaching\tO\nhigh\tO\nlevels\tO\nin\tO\nindividual\tO\npatients\tO\n.\tO\n\nDue\tO\nto\tO\nthe\tO\nrisk\tO\nof\tO\nthis\tO\ntachycardia\tB-Disease\ninducing\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n,\tO\nwe\tO\nwould\tO\nnot\tO\nrecommend\tO\nthe\tO\nuse\tO\nin\tO\nelderly\tO\npatients\tO\nof\tO\nany\tO\nof\tO\nthe\tO\nephedrine\tB-Chemical\n/\tO\npropofol\tB-Chemical\n/\tO\nmixtures\tO\nstudied\tO\n.\tO\n\nGemcitabine\tB-Chemical\nplus\tO\nvinorelbine\tB-Chemical\nin\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\npatients\tO\nage\tO\n70\tO\nyears\tO\nor\tO\nolder\tO\nor\tO\npatients\tO\nwho\tO\ncannot\tO\nreceive\tO\ncisplatin\tB-Chemical\n.\tO\n\nOncopaz\tO\nCooperative\tO\nGroup\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAlthough\tO\nthe\tO\nprevalence\tO\nof\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\n(\tO\nNSCLC\tB-Disease\n)\tO\nis\tO\nhigh\tO\namong\tO\nelderly\tO\npatients\tO\n,\tO\nfew\tO\ndata\tO\nare\tO\navailable\tO\nregarding\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\nchemotherapy\tO\nin\tO\nthis\tO\ngroup\tO\nof\tO\npatients\tO\n.\tO\n\nRecent\tO\nreports\tO\nindicate\tO\nthat\tO\nsingle\tO\nagent\tO\ntherapy\tO\nwith\tO\nvinorelbine\tB-Chemical\n(\tO\nVNB\tB-Chemical\n)\tO\nor\tO\ngemcitabine\tB-Chemical\n(\tO\nGEM\tB-Chemical\n)\tO\nmay\tO\nobtain\tO\na\tO\nresponse\tO\nrate\tO\nof\tO\n20\tO\n-\tO\n30\tO\n%\tO\nin\tO\nelderly\tO\npatients\tO\n,\tO\nwith\tO\nacceptable\tO\ntoxicity\tB-Disease\nand\tO\nimprovement\tO\nin\tO\nsymptoms\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\nthe\tO\ncombination\tO\nof\tO\nGEM\tB-Chemical\nand\tO\nVNB\tB-Chemical\nin\tO\nelderly\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tB-Disease\nor\tO\nthose\tO\nwith\tO\nsome\tO\ncontraindication\tO\nto\tO\nreceiving\tO\ncisplatin\tB-Chemical\nwere\tO\nassessed\tO\n.\tO\n\nMETHODS\tO\n:\tO\nForty\tO\n-\tO\nnine\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tB-Disease\nwere\tO\nincluded\tO\n,\tO\n38\tO\nof\tO\nwhom\tO\nwere\tO\nage\tO\n>\tO\n/\tO\n=\tO\n70\tO\nyears\tO\nand\tO\n11\tO\nwere\tO\nage\tO\n<\tO\n70\tO\nyears\tO\nbut\tO\nwho\tO\nhad\tO\nsome\tO\ncontraindication\tO\nto\tO\nreceiving\tO\ncisplatin\tB-Chemical\n.\tO\n\nAll\tO\npatients\tO\nwere\tO\nevaluable\tO\nfor\tO\nresponse\tO\nand\tO\ntoxicity\tB-Disease\n.\tO\n\nTreatment\tO\nwas\tO\ncomprised\tO\nof\tO\nVNB\tB-Chemical\n,\tO\n25\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n,\tO\nplus\tO\nGEM\tB-Chemical\n,\tO\n1000\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n,\tO\nboth\tO\non\tO\nDays\tO\n1\tO\n,\tO\n8\tO\n,\tO\nand\tO\n15\tO\nevery\tO\n28\tO\ndays\tO\n.\tO\n\nPatients\tO\nreceived\tO\na\tO\nminimum\tO\nof\tO\nthree\tO\ncourses\tO\nunless\tO\nprogressive\tO\ndisease\tO\nwas\tO\ndetected\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOne\tO\nhundred\tO\nsixty\tO\n-\tO\nfive\tO\ncourses\tO\nwere\tO\nadministered\tO\n,\tO\nwith\tO\na\tO\nmedian\tO\nof\tO\n3\tO\n.\tO\n\n6\tO\ncourses\tO\nper\tO\npatient\tO\n.\tO\n\nThe\tO\noverall\tO\nresponse\tO\nrate\tO\nwas\tO\n26\tO\n%\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n,\tO\n15\tO\n-\tO\n41\tO\n%\tO\n)\tO\n.\tO\n\nTwo\tO\npatients\tO\nattained\tO\na\tO\ncomplete\tO\nresponse\tO\n(\tO\n4\tO\n%\tO\n)\tO\nand\tO\n11\tO\npatients\tO\n(\tO\n22\tO\n%\tO\n)\tO\nachieved\tO\na\tO\npartial\tO\nresponse\tO\n.\tO\n\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nperformance\tO\nstatus\tO\nimproved\tO\nin\tO\n35\tO\n%\tO\nof\tO\nthose\tO\npatients\tO\nwith\tO\nan\tO\ninitial\tO\nvalue\tO\n>\tO\n0\tO\n,\tO\nwhereas\tO\nrelief\tO\nof\tO\nat\tO\nleast\tO\n1\tO\nsymptom\tO\nwithout\tO\nworsening\tO\nof\tO\nother\tO\nsymptoms\tO\nwas\tO\nnoted\tO\nin\tO\n27\tO\npatients\tO\n(\tO\n55\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmedian\tO\ntime\tO\nto\tO\nprogression\tO\nwas\tO\n16\tO\nweeks\tO\nand\tO\nthe\tO\n1\tO\n-\tO\nyear\tO\nsurvival\tO\nrate\tO\nwas\tO\n33\tO\n%\tO\n.\tO\n\nToxicity\tB-Disease\nwas\tO\nmild\tO\n.\tO\n\nSix\tO\npatients\tO\n(\tO\n12\tO\n%\tO\n)\tO\nhad\tO\nWorld\tO\nHealth\tO\nOrganization\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tB-Disease\n,\tO\n2\tO\npatients\tO\n(\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nthrombocytopenia\tB-Disease\n,\tO\nand\tO\n2\tO\npatients\tO\n(\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nGrade\tO\n3\tO\nneurotoxicity\tB-Disease\n.\tO\n\nThree\tO\npatients\tO\nwith\tO\nsevere\tO\nneutropenia\tB-Disease\n(\tO\n6\tO\n%\tO\n)\tO\ndied\tO\nof\tO\nsepsis\tB-Disease\n.\tO\n\nThe\tO\nmedian\tO\nage\tO\nof\tO\nthose\tO\npatients\tO\ndeveloping\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tB-Disease\nwas\tO\nsignificantly\tO\nhigher\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\nremaining\tO\npatients\tO\n(\tO\n75\tO\nyears\tO\nvs\tO\n.\tO\n72\tO\nyears\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n047\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tO\nof\tO\nGEM\tB-Chemical\nand\tO\nVNB\tB-Chemical\nis\tO\nmoderately\tO\nactive\tO\nand\tO\nwell\tO\ntolerated\tO\nexcept\tO\nin\tO\npatients\tO\nage\tO\n>\tO\n/\tO\n=\tO\n75\tO\nyears\tO\n.\tO\n\nThis\tO\nage\tO\ngroup\tO\nhad\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nmyelosuppression\tB-Disease\n.\tO\n\nTherefore\tO\nthe\tO\nprophylactic\tO\nuse\tO\nof\tO\ngranulocyte\tO\n-\tO\ncolony\tO\nstimulating\tO\nfactor\tO\nshould\tO\nbe\tO\nconsidered\tO\nwith\tO\nthis\tO\ntreatment\tO\n.\tO\n\nNew\tO\nchemotherapy\tO\ncombinations\tO\nwith\tO\nhigher\tO\nactivity\tO\nand\tO\nlower\tO\ntoxicity\tB-Disease\nare\tO\nneeded\tO\nfor\tO\nelderly\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tB-Disease\n.\tO\n\nA\tO\nselective\tO\ndopamine\tB-Chemical\nD4\tO\nreceptor\tO\nantagonist\tO\n,\tO\nNRA0160\tB-Chemical\n:\tO\na\tO\npreclinical\tO\nneuropharmacological\tO\nprofile\tO\n.\tO\n\nNRA0160\tB-Chemical\n,\tO\n5\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nfluorobenzylidene\tI-Chemical\n)\tI-Chemical\npiperidin\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nfluorophenyl\tI-Chemical\n)\tI-Chemical\nthiazole\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ncarboxamide\tI-Chemical\n,\tO\nhas\tO\na\tO\nhigh\tO\naffinity\tO\nfor\tO\nhuman\tO\ncloned\tO\ndopamine\tB-Chemical\nD4\tO\n.\tO\n2\tO\n,\tO\nD4\tO\n.\tO\n4\tO\nand\tO\nD4\tO\n.\tO\n7\tO\nreceptors\tO\n,\tO\nwith\tO\nKi\tO\nvalues\tO\nof\tO\n0\tO\n.\tO\n5\tO\n,\tO\n0\tO\n.\tO\n9\tO\nand\tO\n2\tO\n.\tO\n7\tO\nnM\tO\n,\tO\nrespectively\tO\n.\tO\n\nNRA0160\tB-Chemical\nis\tO\nover\tO\n20\tO\n,\tO\n000fold\tO\nmore\tO\npotent\tO\nat\tO\nthe\tO\ndopamine\tB-Chemical\nD4\tO\n.\tO\n2\tO\nreceptor\tO\ncompared\tO\nwith\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tB-Chemical\nD2L\tO\nreceptor\tO\n.\tO\n\nNRA0160\tB-Chemical\nhas\tO\nnegligible\tO\naffinity\tO\nfor\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tB-Chemical\nD3\tO\nreceptor\tO\n(\tO\nKi\tO\n=\tO\n39\tO\nnM\tO\n)\tO\n,\tO\nrat\tO\nserotonin\tB-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n)\tO\n2A\tO\nreceptors\tO\n(\tO\nKi\tO\n=\tO\n180\tO\nnM\tO\n)\tO\nand\tO\nrat\tO\nalpha1\tO\nadrenoceptor\tO\n(\tO\nKi\tO\n=\tO\n237\tO\nnM\tO\n)\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nantagonized\tO\nlocomotor\tO\nhyperactivity\tB-Disease\ninduced\tO\nby\tO\nmethamphetamine\tB-Chemical\n(\tO\nMAP\tB-Chemical\n)\tO\nin\tO\nmice\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nantagonized\tO\nMAP\tB-Chemical\n-\tO\ninduced\tO\nstereotyped\tO\nbehavior\tO\nin\tO\nmice\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tO\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninhibition\tO\n,\tO\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nsignificantly\tO\ninduced\tO\ncatalepsy\tB-Disease\nin\tO\nrats\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tO\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninduction\tO\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nsignificantly\tO\nreversed\tO\nthe\tO\ndisruption\tO\nof\tO\nprepulse\tO\ninhibition\tO\n(\tO\nPPI\tO\n)\tO\nin\tO\nrats\tO\nproduced\tO\nby\tO\napomorphine\tB-Chemical\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nsignificantly\tO\nshortened\tO\nthe\tO\nphencyclidine\tB-Chemical\n(\tO\nPCP\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nprolonged\tO\nswimming\tO\nlatency\tO\nin\tO\nrats\tO\nin\tO\na\tO\nwater\tO\nmaze\tO\ntask\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nNRA0160\tB-Chemical\nmay\tO\nhave\tO\nunique\tO\nantipsychotic\tO\nactivities\tO\nwithout\tO\nthe\tO\nliability\tO\nof\tO\nmotor\tO\nside\tO\neffects\tO\ntypical\tO\nof\tO\nclassical\tO\nantipsychotics\tO\n.\tO\n\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\nartery\tB-Disease\ncalcification\tI-Disease\nis\tO\naccelerated\tO\nby\tO\ngrowth\tO\nand\tO\nvitamin\tB-Chemical\nD\tI-Chemical\n.\tO\n\nThe\tO\npresent\tO\nstudies\tO\ndemonstrate\tO\nthat\tO\ngrowth\tO\nand\tO\nvitamin\tB-Chemical\nD\tI-Chemical\ntreatment\tO\nenhance\tO\nthe\tO\nextent\tO\nof\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nrats\tO\ngiven\tO\nsufficient\tO\ndoses\tO\nof\tO\nWarfarin\tB-Chemical\nto\tO\ninhibit\tO\ngamma\tO\n-\tO\ncarboxylation\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\n,\tO\na\tO\ncalcification\tB-Disease\ninhibitor\tO\nknown\tO\nto\tO\nbe\tO\nexpressed\tO\nby\tO\nsmooth\tO\nmuscle\tO\ncells\tO\nand\tO\nmacrophages\tO\nin\tO\nthe\tO\nartery\tO\nwall\tO\n.\tO\n\nThe\tO\nfirst\tO\nseries\tO\nof\tO\nexperiments\tO\nexamined\tO\nthe\tO\ninfluence\tO\nof\tO\nage\tO\nand\tO\ngrowth\tO\nstatus\tO\non\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nWarfarin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nTreatment\tO\nfor\tO\n2\tO\nweeks\tO\nwith\tO\nWarfarin\tB-Chemical\ncaused\tO\nmassive\tO\nfocal\tO\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\nin\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nless\tO\nextensive\tO\nfocal\tO\ncalcification\tB-Disease\nin\tO\n42\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nno\tO\nartery\tB-Disease\ncalcification\tI-Disease\ncould\tO\nbe\tO\ndetected\tO\nin\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nadult\tO\nrats\tO\neven\tO\nafter\tO\n4\tO\nweeks\tO\nof\tO\nWarfarin\tB-Chemical\ntreatment\tO\n.\tO\n\nTo\tO\ndirectly\tO\nexamine\tO\nthe\tO\nimportance\tO\nof\tO\ngrowth\tO\nto\tO\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nanimals\tO\nof\tO\nthe\tO\nsame\tO\nage\tO\n,\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\nwere\tO\nfed\tO\nfor\tO\n2\tO\nweeks\tO\neither\tO\nan\tO\nad\tO\nlibitum\tO\ndiet\tO\nor\tO\na\tO\n6\tO\n-\tO\ng\tO\n/\tO\nd\tO\nrestricted\tO\ndiet\tO\nthat\tO\nmaintains\tO\nweight\tO\nbut\tO\nprevents\tO\ngrowth\tO\n.\tO\n\nConcurrent\tO\ntreatment\tO\nof\tO\nboth\tO\ndietary\tO\ngroups\tO\nwith\tO\nWarfarin\tB-Chemical\nproduced\tO\nmassive\tO\nfocal\tO\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\nin\tO\nthe\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\nbut\tO\nno\tO\ndetectable\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\ngroup\tO\n.\tO\n\nAlthough\tO\nthe\tO\nexplanation\tO\nfor\tO\nthe\tO\nassociation\tO\nbetween\tO\nartery\tB-Disease\ncalcification\tI-Disease\nand\tO\ngrowth\tO\nstatus\tO\ncannot\tO\nbe\tO\ndetermined\tO\nfrom\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nrelationship\tO\nbetween\tO\nhigher\tO\nserum\tO\nphosphate\tB-Chemical\nand\tO\nsusceptibility\tO\nto\tO\nartery\tB-Disease\ncalcification\tI-Disease\n,\tO\nwith\tO\n30\tO\n%\tO\nhigher\tO\nlevels\tO\nof\tO\nserum\tO\nphosphate\tB-Chemical\nin\tO\nyoung\tO\n,\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\ncompared\tO\nwith\tO\neither\tO\nof\tO\nthe\tO\ngroups\tO\nthat\tO\nwas\tO\nresistant\tO\nto\tO\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\nartery\tB-Disease\ncalcification\tI-Disease\n,\tO\nie\tO\n,\tO\nthe\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\nyoung\tO\nrats\tO\n.\tO\n\nThis\tO\nobservation\tO\nsuggests\tO\nthat\tO\nincreased\tO\nsusceptibility\tO\nto\tO\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\nartery\tB-Disease\ncalcification\tI-Disease\ncould\tO\nbe\tO\nrelated\tO\nto\tO\nhigher\tO\nserum\tO\nphosphate\tB-Chemical\nlevels\tO\n.\tO\n\nThe\tO\nsecond\tO\nset\tO\nof\tO\nexperiments\tO\nexamined\tO\nthe\tO\npossible\tO\nsynergy\tO\nbetween\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nand\tO\nWarfarin\tB-Chemical\nin\tO\nartery\tB-Disease\ncalcification\tI-Disease\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nare\tO\nknown\tO\nto\tO\ncause\tO\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\nin\tO\nas\tO\nlittle\tO\nas\tO\n3\tO\nto\tO\n4\tO\ndays\tO\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\nthe\tO\nvitamin\tB-Chemical\nK\tI-Chemical\nantagonist\tO\nWarfarin\tB-Chemical\nare\tO\nalso\tO\nknown\tO\nto\tO\ncause\tO\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\n,\tO\nbut\tO\nat\tO\ntreatment\tO\ntimes\tO\nof\tO\n2\tO\nweeks\tO\nor\tO\nlonger\tO\nyet\tO\nnot\tO\nat\tO\n1\tO\nweek\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\nsynergy\tO\nbetween\tO\nthese\tO\n2\tO\ntreatments\tO\nand\tO\nfound\tO\nthat\tO\nconcurrent\tO\nWarfarin\tB-Chemical\nadministration\tO\ndramatically\tO\nincreased\tO\nthe\tO\nextent\tO\nof\tO\ncalcification\tB-Disease\nin\tO\nthe\tO\nmedia\tO\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\n-\tO\ntreated\tO\nrats\tO\nat\tO\n3\tO\nand\tO\n4\tO\ndays\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nclose\tO\nparallel\tO\nbetween\tO\nthe\tO\neffect\tO\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\ndose\tO\non\tO\nartery\tB-Disease\ncalcification\tI-Disease\nand\tO\nthe\tO\neffect\tO\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\ndose\tO\non\tO\nthe\tO\nelevation\tO\nof\tO\nserum\tO\ncalcium\tB-Chemical\n,\tO\nwhich\tO\nsuggests\tO\nthat\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nmay\tO\ninduce\tO\nartery\tB-Disease\ncalcification\tI-Disease\nthrough\tO\nits\tO\neffect\tO\non\tO\nserum\tO\ncalcium\tB-Chemical\n.\tO\n\nBecause\tO\nWarfarin\tB-Chemical\ntreatment\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nelevation\tO\nin\tO\nserum\tO\ncalcium\tB-Chemical\nproduced\tO\nby\tO\nvitamin\tB-Chemical\nD\tI-Chemical\n,\tO\nthe\tO\nsynergy\tO\nbetween\tO\nWarfarin\tB-Chemical\nand\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nis\tO\nprobably\tO\nbest\tO\nexplained\tO\nby\tO\nthe\tO\nhypothesis\tO\nthat\tO\nWarfarin\tB-Chemical\ninhibits\tO\nthe\tO\nactivity\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nas\tO\na\tO\ncalcification\tB-Disease\ninhibitor\tO\n.\tO\n\nHigh\tO\nlevels\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\nfound\tO\nat\tO\nsites\tO\nof\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nrats\tO\ntreated\tO\nwith\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nplus\tO\nWarfarin\tB-Chemical\n,\tO\nand\tO\nchemical\tO\nanalysis\tO\nshowed\tO\nthat\tO\nthe\tO\nprotein\tO\nthat\tO\naccumulated\tO\nwas\tO\nindeed\tO\nnot\tO\ngamma\tB-Chemical\n-\tI-Chemical\ncarboxylated\tI-Chemical\n.\tO\n\nThese\tO\nobservations\tO\nindicate\tO\nthat\tO\nalthough\tO\nthe\tO\ngamma\tB-Chemical\n-\tI-Chemical\ncarboxyglutamate\tI-Chemical\nresidues\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\napparently\tO\nrequired\tO\nfor\tO\nits\tO\nfunction\tO\nas\tO\na\tO\ncalcification\tB-Disease\ninhibitor\tO\n,\tO\nthey\tO\nare\tO\nnot\tO\nrequired\tO\nfor\tO\nits\tO\naccumulation\tO\nat\tO\ncalcification\tB-Disease\nsites\tO\n.\tO\n\nTest\tO\nconditions\tO\ninfluence\tO\nthe\tO\nresponse\tO\nto\tO\na\tO\ndrug\tO\nchallenge\tO\nin\tO\nrodents\tO\n.\tO\n\nThese\tO\nstudies\tO\nwere\tO\nconducted\tO\nto\tO\nexamine\tO\nthe\tO\ndifferential\tO\nresponse\tO\nto\tO\na\tO\ndrug\tO\nchallenge\tO\nunder\tO\nvaried\tO\nexperimental\tO\ntest\tO\nconditions\tO\nroutinely\tO\nemployed\tO\nto\tO\nstudy\tO\ndrug\tO\n-\tO\ninduced\tO\nbehavioral\tO\nand\tO\nneurophysiological\tO\nresponses\tO\nin\tO\nrodents\tO\n.\tO\n\nApomorphine\tB-Chemical\n,\tO\na\tO\nnonselective\tO\ndopamine\tB-Chemical\nagonist\tI-Chemical\n,\tO\nwas\tO\nselected\tO\ndue\tO\nto\tO\nits\tO\nbiphasic\tO\nbehavioral\tO\neffects\tO\n,\tO\nits\tO\nability\tO\nto\tO\ninduce\tO\nhypothermia\tB-Disease\n,\tO\nand\tO\nto\tO\nproduce\tO\ndistinct\tO\nchanges\tO\nto\tO\ndopamine\tB-Chemical\nturnover\tO\nin\tO\nthe\tO\nrodent\tO\nbrain\tO\n.\tO\n\nFrom\tO\nsuch\tO\nexperiments\tO\nthere\tO\nis\tO\nevidence\tO\nthat\tO\ncharacterization\tO\nand\tO\ndetection\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nactivity\tO\nin\tO\nrodents\tO\ncritically\tO\ndepends\tO\nupon\tO\nthe\tO\ntest\tO\nconditions\tO\nemployed\tO\n.\tO\n\nIn\tO\nrats\tO\n,\tO\ndetection\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nwas\tO\nfacilitated\tO\nby\tO\na\tO\nperiod\tO\nof\tO\nacclimatization\tO\nto\tO\nthe\tO\ntest\tO\nconditions\tO\n.\tO\n\nMoreover\tO\n,\tO\ntest\tO\nconditions\tO\ncan\tO\nimpact\tO\nupon\tO\nother\tO\nphysiological\tO\nresponses\tO\nto\tO\napomorphine\tB-Chemical\nsuch\tO\nas\tO\ndrug\tO\n-\tO\ninduced\tO\nhypothermia\tB-Disease\n.\tO\n\nIn\tO\nmice\tO\n,\tO\napomorphine\tB-Chemical\nproduced\tO\nqualitatively\tO\ndifferent\tO\nresponses\tO\nunder\tO\nnovel\tO\nconditions\tO\nwhen\tO\ncompared\tO\nto\tO\nthose\tO\nbehaviors\tO\nelicited\tO\nin\tO\nthe\tO\nhome\tO\ntest\tO\ncage\tO\n.\tO\n\nDrug\tO\n-\tO\ninduced\tO\ngross\tO\nactivity\tO\ncounts\tO\nwere\tO\nincreased\tO\nin\tO\nthe\tO\nnovel\tO\nexploratory\tO\nbox\tO\nonly\tO\n,\tO\nwhile\tO\nmeasures\tO\nof\tO\nstereotypic\tO\nbehavior\tO\nwere\tO\nsimilar\tO\nin\tO\nboth\tO\n.\tO\n\nBy\tO\ncontrast\tO\n,\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nlocomotion\tO\nwas\tO\nmore\tO\nprominent\tO\nin\tO\nthe\tO\nnovel\tO\nexploratory\tO\nbox\tO\n.\tO\n\nDopamine\tB-Chemical\nturnover\tO\nratios\tO\n(\tO\nDOPAC\tB-Chemical\n:\tO\nDA\tB-Chemical\nand\tO\nHVA\tB-Chemical\n:\tO\nDA\tB-Chemical\n)\tO\nwere\tO\nfound\tO\nto\tO\nbe\tO\nlower\tO\nin\tO\nthose\tO\nanimals\tO\nexposed\tO\nto\tO\nthe\tO\nexploratory\tO\nbox\tO\nwhen\tO\ncompared\tO\nto\tO\ntheir\tO\nhome\tO\ncage\tO\ncounterparts\tO\n.\tO\n\nHowever\tO\n,\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nreductions\tO\nin\tO\nstriatal\tO\ndopamine\tB-Chemical\nturnover\tO\nwere\tO\ndetected\tO\nin\tO\nboth\tO\nnovel\tO\nand\tO\nhome\tO\ncage\tO\nenvironments\tO\n.\tO\n\nThe\tO\nimplications\tO\nof\tO\nthese\tO\nfindings\tO\nare\tO\ndiscussed\tO\nwith\tO\nparticular\tO\nemphasis\tO\nupon\tO\nconducting\tO\npsychopharmacological\tO\nchallenge\tO\ntests\tO\nin\tO\nrodents\tO\n.\tO\n\nHemolysis\tB-Disease\nof\tO\nhuman\tO\nerythrocytes\tO\ninduced\tO\nby\tO\ntamoxifen\tB-Chemical\nis\tO\nrelated\tO\nto\tO\ndisruption\tO\nof\tO\nmembrane\tO\nstructure\tO\n.\tO\n\nTamoxifen\tB-Chemical\n(\tO\nTAM\tB-Chemical\n)\tO\n,\tO\nthe\tO\nantiestrogenic\tO\ndrug\tO\nmost\tO\nwidely\tO\nprescribed\tO\nin\tO\nthe\tO\nchemotherapy\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\ninduces\tO\nchanges\tO\nin\tO\nnormal\tO\ndiscoid\tO\nshape\tO\nof\tO\nerythrocytes\tO\nand\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\neffects\tO\nof\tO\nTAM\tB-Chemical\non\tO\nisolated\tO\nhuman\tO\nerythrocytes\tO\n,\tO\nattempting\tO\nto\tO\nidentify\tO\nthe\tO\nunderlying\tO\nmechanisms\tO\non\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nand\tO\nthe\tO\ninvolvement\tO\nof\tO\nbiomembranes\tO\nin\tO\nits\tO\ncytostatic\tO\naction\tO\nmechanisms\tO\n.\tO\n\nTAM\tB-Chemical\ninduces\tO\nhemolysis\tB-Disease\nof\tO\nerythrocytes\tO\nas\tO\na\tO\nfunction\tO\nof\tO\nconcentration\tO\n.\tO\n\nThe\tO\nextension\tO\nof\tO\nhemolysis\tB-Disease\nis\tO\nvariable\tO\nwith\tO\nerythrocyte\tO\nsamples\tO\n,\tO\nbut\tO\n12\tO\n.\tO\n5\tO\nmicroM\tO\nTAM\tB-Chemical\ninduces\tO\ntotal\tO\nhemolysis\tB-Disease\nof\tO\nall\tO\ntested\tO\nsuspensions\tO\n.\tO\n\nDespite\tO\ninducing\tO\nextensive\tO\nerythrocyte\tO\nlysis\tO\n,\tO\nTAM\tB-Chemical\ndoes\tO\nnot\tO\nshift\tO\nthe\tO\nosmotic\tO\nfragility\tO\ncurves\tO\nof\tO\nerythrocytes\tO\n.\tO\n\nThe\tO\nhemolytic\tB-Disease\neffect\tO\nof\tO\nTAM\tB-Chemical\nis\tO\nprevented\tO\nby\tO\nlow\tO\nconcentrations\tO\nof\tO\nalpha\tB-Chemical\n-\tI-Chemical\ntocopherol\tI-Chemical\n(\tO\nalpha\tB-Chemical\n-\tI-Chemical\nT\tI-Chemical\n)\tO\nand\tO\nalpha\tB-Chemical\n-\tI-Chemical\ntocopherol\tI-Chemical\nacetate\tI-Chemical\n(\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTAc\tI-Chemical\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tB-Chemical\n)\tO\nindicating\tO\nthat\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\nhemolysis\tB-Disease\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tO\nmembrane\tO\ndamage\tO\n.\tO\n\nThis\tO\nwas\tO\nfurther\tO\nevidenced\tO\nby\tO\nabsence\tO\nof\tO\noxygen\tB-Chemical\nconsumption\tO\nand\tO\nhemoglobin\tO\noxidation\tO\nboth\tO\ndetermined\tO\nin\tO\nparallel\tO\nwith\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\nhemolysis\tB-Disease\n.\tO\n\nFurthermore\tO\n,\tO\nit\tO\nwas\tO\nobserved\tO\nthat\tO\nTAM\tB-Chemical\ninhibits\tO\nthe\tO\nperoxidation\tO\nof\tO\nhuman\tO\nerythrocytes\tO\ninduced\tO\nby\tO\nAAPH\tB-Chemical\n,\tO\nthus\tO\nruling\tO\nout\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\ncell\tO\noxidative\tO\nstress\tO\n.\tO\n\nHemolysis\tB-Disease\ncaused\tO\nby\tO\nTAM\tB-Chemical\nwas\tO\nnot\tO\npreceded\tO\nby\tO\nthe\tO\nleakage\tO\nof\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\nfrom\tO\nthe\tO\ncells\tO\n,\tO\nalso\tO\nexcluding\tO\na\tO\ncolloid\tO\n-\tO\nosmotic\tO\ntype\tO\nmechanism\tO\nof\tO\nhemolysis\tB-Disease\n,\tO\naccording\tO\nto\tO\nthe\tO\neffects\tO\non\tO\nosmotic\tO\nfragility\tO\ncurves\tO\n.\tO\n\nHowever\tO\n,\tO\nTAM\tB-Chemical\ninduces\tO\nrelease\tO\nof\tO\nperipheral\tO\nproteins\tO\nof\tO\nmembrane\tO\n-\tO\ncytoskeleton\tO\nand\tO\ncytosol\tO\nproteins\tO\nessentially\tO\nbound\tO\nto\tO\nband\tO\n3\tO\n.\tO\n\nEither\tO\nalpha\tB-Chemical\n-\tI-Chemical\nT\tI-Chemical\nor\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTAc\tI-Chemical\nincreases\tO\nmembrane\tO\npacking\tO\nand\tO\nprevents\tO\nTAM\tB-Chemical\npartition\tO\ninto\tO\nmodel\tO\nmembranes\tO\n.\tO\n\nThese\tO\neffects\tO\nsuggest\tO\nthat\tO\nthe\tO\nprotection\tO\nfrom\tO\nhemolysis\tB-Disease\nby\tO\ntocopherols\tB-Chemical\nis\tO\nrelated\tO\nto\tO\na\tO\ndecreased\tO\nTAM\tB-Chemical\nincorporation\tO\nin\tO\ncondensed\tO\nmembranes\tO\nand\tO\nthe\tO\nstructural\tO\ndamage\tO\nof\tO\nthe\tO\nerythrocyte\tO\nmembrane\tO\nis\tO\nconsequently\tO\navoided\tO\n.\tO\n\nTherefore\tO\n,\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\nhemolysis\tB-Disease\nresults\tO\nfrom\tO\na\tO\nstructural\tO\nperturbation\tO\nof\tO\nred\tO\ncell\tO\nmembrane\tO\n,\tO\nleading\tO\nto\tO\nchanges\tO\nin\tO\nthe\tO\nframework\tO\nof\tO\nthe\tO\nerythrocyte\tO\nmembrane\tO\nand\tO\nits\tO\ncytoskeleton\tO\ncaused\tO\nby\tO\nits\tO\nhigh\tO\npartition\tO\nin\tO\nthe\tO\nmembrane\tO\n.\tO\n\nThese\tO\ndefects\tO\nexplain\tO\nthe\tO\nabnormal\tO\nerythrocyte\tO\nshape\tO\nand\tO\ndecreased\tO\nmechanical\tO\nstability\tO\npromoted\tO\nby\tO\nTAM\tB-Chemical\n,\tO\nresulting\tO\nin\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nAdditionally\tO\n,\tO\nsince\tO\nmembrane\tO\nleakage\tO\nis\tO\na\tO\nfinal\tO\nstage\tO\nof\tO\ncytotoxicity\tO\n,\tO\nthe\tO\ndisruption\tO\nof\tO\nthe\tO\nstructural\tO\ncharacteristics\tO\nof\tO\nbiomembranes\tO\nby\tO\nTAM\tB-Chemical\nmay\tO\ncontribute\tO\nto\tO\nthe\tO\nmultiple\tO\nmechanisms\tO\nof\tO\nits\tO\nanticancer\tO\naction\tO\n.\tO\n\nChanges\tO\nof\tO\nsodium\tB-Chemical\nand\tO\nATP\tB-Chemical\naffinities\tO\nof\tO\nthe\tO\ncardiac\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nduring\tO\nand\tO\nafter\tO\nnitric\tB-Chemical\noxide\tI-Chemical\ndeficient\tO\nhypertension\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\ncardiovascular\tO\nsystem\tO\n,\tO\nNO\tB-Chemical\nis\tO\ninvolved\tO\nin\tO\nthe\tO\nregulation\tO\nof\tO\na\tO\nvariety\tO\nof\tO\nfunctions\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tB-Chemical\nsynthesis\tO\ninduces\tO\nsustained\tO\nhypertension\tB-Disease\n.\tO\n\nIn\tO\nseveral\tO\nmodels\tO\nof\tO\nhypertension\tB-Disease\n,\tO\nelevation\tO\nof\tO\nintracellular\tO\nsodium\tB-Chemical\nlevel\tO\nwas\tO\ndocumented\tO\nin\tO\ncardiac\tO\ntissue\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tO\nof\tO\nNa\tB-Chemical\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tO\nof\tO\ncardiac\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tB-Chemical\n-\tO\ndeficient\tO\nhypertension\tB-Disease\ninduced\tO\nin\tO\nrats\tO\nby\tO\nNO\tB-Chemical\n-\tO\nsynthase\tO\ninhibition\tO\nwith\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nN\tB-Chemical\n(\tI-Chemical\nG\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nnitro\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nmethyl\tI-Chemical\nester\tI-Chemical\n(\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nAfter\tO\n4\tO\n-\tO\nweek\tO\nadministration\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n,\tO\nthe\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\nSBP\tO\n)\tO\nincreased\tO\nby\tO\n36\tO\n%\tO\n.\tO\n\nTwo\tO\nweeks\tO\nafter\tO\nterminating\tO\nthe\tO\ntreatment\tO\n,\tO\nthe\tO\nSBP\tO\nrecovered\tO\nto\tO\ncontrol\tO\nvalue\tO\n.\tO\n\nWhen\tO\nactivating\tO\nthe\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nwith\tO\nits\tO\nsubstrate\tO\nATP\tB-Chemical\n,\tO\nno\tO\nchanges\tO\nin\tO\nKm\tO\nand\tO\nVmax\tO\nvalues\tO\nwere\tO\nobserved\tO\nin\tO\nNO\tB-Chemical\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nDuring\tO\nactivation\tO\nwith\tO\nNa\tB-Chemical\n+\tO\n,\tO\nthe\tO\nVmax\tO\nremained\tO\nunchanged\tO\n,\tO\nhowever\tO\nthe\tO\nK\tB-Chemical\n(\tO\nNa\tB-Chemical\n)\tO\nincreased\tO\nby\tO\n50\tO\n%\tO\n,\tO\nindicating\tO\na\tO\nprofound\tO\ndecrease\tO\nin\tO\nthe\tO\naffinity\tO\nof\tO\nthe\tO\nNa\tB-Chemical\n+\tO\n-\tO\nbinding\tO\nsite\tO\nin\tO\nNO\tB-Chemical\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nfrom\tO\nhypertension\tB-Disease\n,\tO\nthe\tO\nactivity\tO\nof\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nincreased\tO\n,\tO\ndue\tO\nto\tO\nhigher\tO\naffinity\tO\nof\tO\nthe\tO\nATP\tB-Chemical\n-\tO\nbinding\tO\nsite\tO\n,\tO\nas\tO\nrevealed\tO\nfrom\tO\nthe\tO\nlowered\tO\nKm\tO\nvalue\tO\nfor\tO\nATP\tB-Chemical\n.\tO\n\nThe\tO\nK\tB-Chemical\n(\tO\nNa\tB-Chemical\n)\tO\nvalue\tO\nfor\tO\nNa\tB-Chemical\n+\tO\nreturned\tO\nto\tO\ncontrol\tO\nvalue\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tB-Chemical\n-\tO\nsynthase\tO\ninduced\tO\na\tO\nreversible\tO\nhypertension\tB-Disease\naccompanied\tO\nby\tO\ndepressed\tB-Disease\nNa\tB-Chemical\n+\tO\n-\tO\nextrusion\tO\nfrom\tO\ncardiac\tO\ncells\tO\nas\tO\na\tO\nconsequence\tO\nof\tO\ndeteriorated\tO\nNa\tB-Chemical\n+\tO\n-\tO\nbinding\tO\nproperties\tO\nof\tO\nthe\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nof\tO\nblood\tO\npressure\tO\nto\tO\ncontrol\tO\nvalues\tO\n,\tO\nthe\tO\nextrusion\tO\nof\tO\nNa\tB-Chemical\n+\tO\nfrom\tO\ncardiac\tO\ncells\tO\nwas\tO\nnormalized\tO\n,\tO\nas\tO\nrevealed\tO\nby\tO\nrestoration\tO\nof\tO\nthe\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nactivity\tO\n.\tO\n\nEffects\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\npretreatment\tO\nwith\tO\nisoproterenol\tB-Chemical\non\tO\nbromocriptine\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nshown\tO\nthat\tO\nbromocriptine\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\n,\tO\nwhich\tO\npersisted\tO\nafter\tO\nadrenalectomy\tO\n,\tO\nis\tO\n(\tO\ni\tO\n)\tO\nmediated\tO\nby\tO\ncentral\tO\ndopamine\tB-Chemical\nD2\tO\nreceptor\tO\nactivation\tO\nand\tO\n(\tO\nii\tO\n)\tO\nreduced\tO\nby\tO\n5\tO\n-\tO\nday\tO\nisoproterenol\tB-Chemical\npretreatment\tO\n,\tO\nsupporting\tO\ntherefore\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthis\tO\neffect\tO\nis\tO\ndependent\tO\non\tO\nsympathetic\tO\noutflow\tO\nto\tO\nthe\tO\nheart\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nconducted\tO\nto\tO\nexamine\tO\nwhether\tO\nprolonged\tO\npretreatment\tO\nwith\tO\nisoproterenol\tB-Chemical\ncould\tO\nabolish\tO\nbromocriptine\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nIsoproterenol\tB-Chemical\npretreatment\tO\nfor\tO\n15\tO\ndays\tO\ncaused\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\nwithout\tO\naffecting\tO\nbaseline\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\n.\tO\n\nIn\tO\ncontrol\tO\nrats\tO\n,\tO\nintravenous\tO\nbromocriptine\tB-Chemical\n(\tO\n150\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\ninduced\tO\nsignificant\tO\nhypotension\tB-Disease\nand\tO\ntachycardia\tB-Disease\n.\tO\n\nBromocriptine\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nwas\tO\nunaffected\tO\nby\tO\nisoproterenol\tB-Chemical\npretreatment\tO\n,\tO\nwhile\tO\ntachycardia\tB-Disease\nwas\tO\nreversed\tO\nto\tO\nsignificant\tO\nbradycardia\tB-Disease\n,\tO\nan\tO\neffect\tO\nthat\tO\nwas\tO\npartly\tO\nreduced\tO\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\ndomperidone\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nNeither\tO\ncardiac\tO\nvagal\tO\nnor\tO\nsympathetic\tO\ntone\tO\nwas\tO\naltered\tO\nby\tO\nisoproterenol\tB-Chemical\npretreatment\tO\n.\tO\n\nIn\tO\nisolated\tO\nperfused\tO\nheart\tO\npreparations\tO\nfrom\tO\nisoproterenol\tB-Chemical\n-\tO\npretreated\tO\nrats\tO\n,\tO\nthe\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmaximal\tO\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nsignificantly\tO\nreduced\tO\n,\tO\ncompared\tO\nwith\tO\nsaline\tO\n-\tO\npretreated\tO\nrats\tO\n(\tO\nthe\tO\nEC50\tO\nof\tO\nthe\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nenhanced\tO\napproximately\tO\n22\tO\n-\tO\nfold\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nshow\tO\nthat\tO\n15\tO\n-\tO\nday\tO\nisoproterenol\tB-Chemical\npretreatment\tO\nnot\tO\nonly\tO\nabolished\tO\nbut\tO\nreversed\tO\nbromocriptine\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nto\tO\nbradycardia\tB-Disease\n,\tO\nan\tO\neffect\tO\nthat\tO\nis\tO\nmainly\tO\nrelated\tO\nto\tO\nfurther\tO\ncardiac\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\ndesensitization\tO\nrather\tO\nthan\tO\nto\tO\nimpairment\tO\nof\tO\nautonomic\tO\nregulation\tO\nof\tO\nthe\tO\nheart\tO\n.\tO\n\nThey\tO\nsuggest\tO\nthat\tO\n,\tO\nin\tO\nnormal\tO\nconscious\tO\nrats\tO\n,\tO\nthe\tO\ncentral\tO\ntachycardia\tB-Disease\nof\tO\nbromocriptine\tB-Chemical\nappears\tO\nto\tO\npredominate\tO\nand\tO\nto\tO\nmask\tO\nthe\tO\nbradycardia\tB-Disease\nof\tO\nthis\tO\nagonist\tO\nat\tO\nperipheral\tO\ndopamine\tB-Chemical\nD2\tO\nreceptors\tO\n.\tO\n\nA\tO\ndevelopmental\tO\nanalysis\tO\nof\tO\nclonidine\tB-Chemical\n'\tO\ns\tO\neffects\tO\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nin\tO\ninfant\tO\nrats\tO\n.\tO\n\nUnder\tO\ncontrolled\tO\nconditions\tO\n,\tO\ninfant\tO\nrats\tO\nemit\tO\nultrasonic\tO\nvocalizations\tO\nduring\tO\nextreme\tO\ncold\tO\nexposure\tO\nand\tO\nafter\tO\nadministration\tO\nof\tO\nthe\tO\nalpha\tO\n(\tO\n2\tO\n)\tO\nadrenoceptor\tO\nagonist\tO\n,\tO\nclonidine\tB-Chemical\n.\tO\n\nPrevious\tO\ninvestigations\tO\nhave\tO\ndetermined\tO\nthat\tO\n,\tO\nin\tO\nresponse\tO\nto\tO\nclonidine\tB-Chemical\n,\tO\nultrasound\tO\nproduction\tO\nincreases\tO\nthrough\tO\nthe\tO\n2nd\tO\n-\tO\nweek\tO\npostpartum\tO\nand\tO\ndecreases\tO\nthereafter\tO\n.\tO\n\nGiven\tO\nthat\tO\nsympathetic\tO\nneural\tO\ndominance\tO\nexhibits\tO\na\tO\nsimilar\tO\ndevelopmental\tO\npattern\tO\n,\tO\nand\tO\ngiven\tO\nthat\tO\nclonidine\tB-Chemical\ninduces\tO\nsympathetic\tO\nwithdrawal\tO\nand\tO\nbradycardia\tB-Disease\n,\tO\nwe\tO\nhypothesized\tO\nthat\tO\nclonidine\tB-Chemical\n'\tO\ns\tO\ndevelopmental\tO\neffects\tO\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nwould\tO\nmirror\tO\neach\tO\nother\tO\n.\tO\n\nTherefore\tO\n,\tO\nin\tO\nthe\tO\npresent\tO\nexperiment\tO\n,\tO\nthe\tO\neffects\tO\nof\tO\nclonidine\tB-Chemical\nadministration\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nwere\tO\nexamined\tO\nin\tO\n2\tO\n-\tO\n,\tO\n8\tO\n-\tO\n,\tO\n15\tO\n-\tO\n,\tO\nand\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\n.\tO\n\nAge\tO\n-\tO\nrelated\tO\nchanges\tO\nin\tO\nultrasound\tO\nproduction\tO\ncorresponded\tO\nwith\tO\nchanges\tO\nin\tO\ncardiovascular\tO\nvariables\tO\n,\tO\nincluding\tO\nbaseline\tO\ncardiac\tO\nrate\tO\nand\tO\nclonidine\tB-Chemical\n-\tO\ninduced\tO\nbradycardia\tB-Disease\n.\tO\n\nThis\tO\nexperiment\tO\nis\tO\ndiscussed\tO\nwith\tO\nregard\tO\nto\tO\nthe\tO\nhypothesis\tO\nthat\tO\nultrasound\tO\nproduction\tO\nis\tO\nthe\tO\nacoustic\tO\nby\tO\n-\tO\nproduct\tO\nof\tO\na\tO\nphysiological\tO\nmaneuver\tO\nthat\tO\ncompensates\tO\nfor\tO\nclonidine\tB-Chemical\n'\tO\ns\tO\ndetrimental\tO\neffects\tO\non\tO\ncardiovascular\tO\nfunction\tO\n.\tO\n\nRecurrent\tO\nuse\tO\nof\tO\nnewer\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n.\tO\n\nThe\tO\nepidemiological\tO\nstudies\tO\nthat\tO\nassessed\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tB-Disease\n)\tO\nassociated\tO\nwith\tO\nnewer\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n(\tO\nOC\tB-Chemical\n)\tO\ndid\tO\nnot\tO\ndistinguish\tO\nbetween\tO\npatterns\tO\nof\tO\nOC\tB-Chemical\nuse\tO\n,\tO\nnamely\tO\nfirst\tO\n-\tO\ntime\tO\nusers\tO\n,\tO\nrepeaters\tO\nand\tO\nswitchers\tO\n.\tO\n\nData\tO\nfrom\tO\na\tO\nTransnational\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nwere\tO\nused\tO\nto\tO\nassess\tO\nthe\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nfor\tO\nthe\tO\nlatter\tO\npatterns\tO\nof\tO\nuse\tO\n,\tO\nwhile\tO\naccounting\tO\nfor\tO\nduration\tO\nof\tO\nuse\tO\n.\tO\n\nOver\tO\nthe\tO\nperiod\tO\n1993\tO\n-\tO\n1996\tO\n,\tO\n551\tO\ncases\tO\nof\tO\nVTE\tB-Disease\nwere\tO\nidentified\tO\nin\tO\nGermany\tO\nand\tO\nthe\tO\nUK\tO\nalong\tO\nwith\tO\n2066\tO\ncontrols\tO\n.\tO\n\nTotals\tO\nof\tO\n128\tO\ncases\tO\nand\tO\n650\tO\ncontrols\tO\nwere\tO\nanalysed\tO\nfor\tO\nrepeat\tO\nuse\tO\nand\tO\n135\tO\ncases\tO\nand\tO\n622\tO\ncontrols\tO\nfor\tO\nswitching\tO\npatterns\tO\n.\tO\n\nThe\tO\nadjusted\tO\nrate\tO\nratio\tO\nof\tO\nVTE\tB-Disease\nfor\tO\nrepeat\tO\nusers\tO\nof\tO\nthird\tO\ngeneration\tO\nOC\tB-Chemical\nwas\tO\n0\tO\n.\tO\n6\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n3\tO\n-\tO\n1\tO\n.\tO\n2\tO\n)\tO\nrelative\tO\nto\tO\nrepeat\tO\nusers\tO\nof\tO\nsecond\tO\ngeneration\tO\npills\tO\n,\tO\nwhereas\tO\nit\tO\nwas\tO\n1\tO\n.\tO\n3\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n7\tO\n-\tO\n2\tO\n.\tO\n4\tO\n)\tO\nfor\tO\nswitchers\tO\nfrom\tO\nsecond\tO\nto\tO\nthird\tO\ngeneration\tO\npills\tO\nrelative\tO\nto\tO\nswitchers\tO\nfrom\tO\nthird\tO\nto\tO\nsecond\tO\ngeneration\tO\npills\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nsecond\tO\nand\tO\nthird\tO\ngeneration\tO\nagents\tO\nare\tO\nassociated\tO\nwith\tO\nequivalent\tO\nrisks\tO\nof\tO\nVTE\tB-Disease\nwhen\tO\nthe\tO\nsame\tO\nagent\tO\nis\tO\nused\tO\nrepeatedly\tO\nafter\tO\ninterruption\tO\nperiods\tO\nor\tO\nwhen\tO\nusers\tO\nare\tO\nswitched\tO\nbetween\tO\nthe\tO\ntwo\tO\ngenerations\tO\nof\tO\npills\tO\n.\tO\n\nThese\tO\nanalyses\tO\nsuggest\tO\nthat\tO\nthe\tO\nhigher\tO\nrisk\tO\nobserved\tO\nfor\tO\nthe\tO\nnewer\tO\nOC\tB-Chemical\nin\tO\nother\tO\nstudies\tO\nmay\tO\nbe\tO\nthe\tO\nresult\tO\nof\tO\ninadequate\tO\ncomparisons\tO\nof\tO\npill\tO\nusers\tO\nwith\tO\ndifferent\tO\npatterns\tO\nof\tO\npill\tO\nuse\tO\n.\tO\n\nDifferential\tO\neffects\tO\nof\tO\nsystemically\tO\nadministered\tO\nketamine\tB-Chemical\nand\tO\nlidocaine\tB-Chemical\non\tO\ndynamic\tO\nand\tO\nstatic\tO\nhyperalgesia\tB-Disease\ninduced\tO\nby\tO\nintradermal\tO\ncapsaicin\tB-Chemical\nin\tO\nhumans\tO\n.\tO\n\nWe\tO\nhave\tO\nexamined\tO\nthe\tO\neffect\tO\nof\tO\nsystemic\tO\nadministration\tO\nof\tO\nketamine\tB-Chemical\nand\tO\nlidocaine\tB-Chemical\non\tO\nbrush\tO\n-\tO\nevoked\tO\n(\tO\ndynamic\tO\n)\tO\npain\tB-Disease\nand\tO\npunctate\tO\n-\tO\nevoked\tO\n(\tO\nstatic\tO\n)\tO\nhyperalgesia\tB-Disease\ninduced\tO\nby\tO\ncapsaicin\tB-Chemical\n.\tO\n\nIn\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ncrossover\tO\nstudy\tO\n,\tO\nwe\tO\nstudied\tO\n12\tO\nvolunteers\tO\nin\tO\nthree\tO\nexperiments\tO\n.\tO\n\nCapsaicin\tB-Chemical\n100\tO\nmicrograms\tO\nwas\tO\ninjected\tO\nintradermally\tO\non\tO\nthe\tO\nvolar\tO\nforearm\tO\nfollowed\tO\nby\tO\nan\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusion\tO\nof\tO\nketamine\tB-Chemical\n(\tO\nbolus\tO\n0\tO\n.\tO\n1\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nover\tO\n10\tO\nmin\tO\nfollowed\tO\nby\tO\ninfusion\tO\nof\tO\n7\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nmin\tO\n-\tO\n1\tO\n)\tO\n,\tO\nlidocaine\tB-Chemical\n5\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nor\tO\nsaline\tO\nfor\tO\n50\tO\nmin\tO\n.\tO\n\nInfusion\tO\nstarted\tO\n15\tO\nmin\tO\nafter\tO\ninjection\tO\nof\tO\ncapsaicin\tB-Chemical\n.\tO\n\nThe\tO\nfollowing\tO\nwere\tO\nmeasured\tO\n:\tO\nspontaneous\tO\npain\tB-Disease\n,\tO\npain\tB-Disease\nevoked\tO\nby\tO\npunctate\tO\nand\tO\nbrush\tO\nstimuli\tO\n(\tO\nVAS\tO\n)\tO\n,\tO\nand\tO\nareas\tO\nof\tO\nbrush\tO\n-\tO\nevoked\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tB-Disease\n.\tO\n\nKetamine\tB-Chemical\nreduced\tO\nboth\tO\nthe\tO\narea\tO\nof\tO\nbrush\tO\n-\tO\nevoked\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tB-Disease\nsignificantly\tO\nand\tO\nit\tO\ntended\tO\nto\tO\nreduce\tO\nbrush\tO\n-\tO\nevoked\tO\npain\tB-Disease\n.\tO\n\nLidocaine\tB-Chemical\nreduced\tO\nthe\tO\narea\tO\nof\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tB-Disease\nsignificantly\tO\n.\tO\n\nIt\tO\ntended\tO\nto\tO\nreduce\tO\nVAS\tO\nscores\tO\nof\tO\nspontaneous\tO\npain\tB-Disease\nbut\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nevoked\tO\npain\tB-Disease\n.\tO\n\nThe\tO\ndifferential\tO\neffects\tO\nof\tO\nketamine\tB-Chemical\nand\tO\nlidocaine\tB-Chemical\non\tO\nstatic\tO\nand\tO\ndynamic\tO\nhyperalgesia\tB-Disease\nsuggest\tO\nthat\tO\nthe\tO\ntwo\tO\ntypes\tO\nof\tO\nhyperalgesia\tB-Disease\nare\tO\nmediated\tO\nby\tO\nseparate\tO\nmechanisms\tO\nand\tO\nhave\tO\na\tO\ndistinct\tO\npharmacology\tO\n.\tO\n\nDevelopment\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\naggressive\tB-Disease\nbehavior\tI-Disease\n:\tO\ncomparison\tO\nof\tO\nadult\tO\nmale\tO\nand\tO\nfemale\tO\nWistar\tO\nrats\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\n(\tO\n1\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nonce\tO\ndaily\tO\n)\tO\naggressive\tB-Disease\nbehavior\tI-Disease\nof\tO\nadult\tO\nmale\tO\nand\tO\nfemale\tO\nWistar\tO\nrats\tO\nobtained\tO\nfrom\tO\nthe\tO\nsame\tO\nbreeder\tO\nwas\tO\nstudied\tO\nin\tO\ntwo\tO\nconsecutive\tO\nsets\tO\n.\tO\n\nIn\tO\nmale\tO\nanimals\tO\n,\tO\nrepeated\tO\napomorphine\tB-Chemical\ntreatment\tO\ninduced\tO\na\tO\ngradual\tO\ndevelopment\tO\nof\tO\naggressive\tB-Disease\nbehavior\tI-Disease\nas\tO\nevidenced\tO\nby\tO\nthe\tO\nincreased\tO\nintensity\tO\nof\tO\naggressiveness\tB-Disease\nand\tO\nshortened\tO\nlatency\tO\nbefore\tO\nthe\tO\nfirst\tO\nattack\tO\ntoward\tO\nthe\tO\nopponent\tO\n.\tO\n\nIn\tO\nfemale\tO\nrats\tO\n,\tO\nonly\tO\na\tO\nweak\tO\ntendency\tO\ntoward\tO\naggressiveness\tB-Disease\nwas\tO\nfound\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\npresent\tO\nstudy\tO\ndemonstrates\tO\ngender\tO\ndifferences\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nthe\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\naggressive\tB-Disease\nbehavior\tI-Disease\nand\tO\nindicates\tO\nthat\tO\nthe\tO\nfemale\tO\nrats\tO\ndo\tO\nnot\tO\nfill\tO\nthe\tO\nvalidation\tO\ncriteria\tO\nfor\tO\nuse\tO\nin\tO\nthis\tO\nmethod\tO\n.\tO\n\nIntracranial\tB-Disease\naneurysms\tI-Disease\nand\tO\ncocaine\tB-Disease\nabuse\tI-Disease\n:\tO\nanalysis\tO\nof\tO\nprognostic\tO\nindicators\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\noutcome\tO\nof\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\nassociated\tO\nwith\tO\ncocaine\tB-Disease\nabuse\tI-Disease\nis\tO\nreportedly\tO\npoor\tO\n.\tO\n\nHowever\tO\n,\tO\nno\tO\nstudy\tO\nin\tO\nthe\tO\nliterature\tO\nhas\tO\nreported\tO\nthe\tO\nuse\tO\nof\tO\na\tO\nstatistical\tO\nmodel\tO\nto\tO\nanalyze\tO\nthe\tO\nvariables\tO\nthat\tO\ninfluence\tO\noutcome\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nreview\tO\nof\tO\nadmissions\tO\nduring\tO\na\tO\n6\tO\n-\tO\nyear\tO\nperiod\tO\nrevealed\tO\n14\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nrelated\tO\naneurysms\tB-Disease\n.\tO\n\nThis\tO\ngroup\tO\nwas\tO\ncompared\tO\nwith\tO\na\tO\ncontrol\tO\ngroup\tO\nof\tO\n135\tO\npatients\tO\nwith\tO\nruptured\tB-Disease\naneurysms\tI-Disease\nand\tO\nno\tO\nhistory\tO\nof\tO\ncocaine\tB-Disease\nabuse\tI-Disease\n.\tO\n\nAge\tO\nat\tO\npresentation\tO\n,\tO\ntime\tO\nof\tO\nictus\tO\nafter\tO\nintoxication\tO\n,\tO\nHunt\tO\nand\tO\nHess\tO\ngrade\tO\nof\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\n,\tO\nsize\tO\nof\tO\nthe\tO\naneurysm\tB-Disease\n,\tO\nlocation\tO\nof\tO\nthe\tO\naneurysm\tB-Disease\n,\tO\nand\tO\nthe\tO\nGlasgow\tO\nOutcome\tO\nScale\tO\nscore\tO\nwere\tO\nassessed\tO\nand\tO\ncompared\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\npatients\tO\nin\tO\nthe\tO\nstudy\tO\ngroup\tO\nwere\tO\nsignificantly\tO\nyounger\tO\nthan\tO\nthe\tO\npatients\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nIn\tO\npatients\tO\nin\tO\nthe\tO\nstudy\tO\ngroup\tO\n,\tO\nall\tO\naneurysms\tB-Disease\nwere\tO\nlocated\tO\nin\tO\nthe\tO\nanterior\tO\ncirculation\tO\n.\tO\n\nThe\tO\nmajority\tO\nof\tO\nthese\tO\naneurysms\tB-Disease\nwere\tO\nsmaller\tO\nthan\tO\nthose\tO\nof\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\n8\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n08\tO\nmm\tO\nversus\tO\n11\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n4\tO\nmm\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\ndifferences\tO\nin\tO\nmortality\tO\nand\tO\nmorbidity\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\nwere\tO\nnot\tO\nsignificant\tO\n.\tO\n\nHunt\tO\nand\tO\nHess\tO\ngrade\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n005\tO\n)\tO\nand\tO\nage\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n007\tO\n)\tO\nwere\tO\nsignificant\tO\npredictors\tO\nof\tO\noutcome\tO\nfor\tO\nthe\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nrelated\tO\naneurysms\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nCocaine\tB-Chemical\nuse\tO\npredisposed\tO\naneurysmal\tB-Disease\nrupture\tI-Disease\nat\tO\na\tO\nsignificantly\tO\nearlier\tO\nage\tO\nand\tO\nin\tO\nmuch\tO\nsmaller\tO\naneurysms\tB-Disease\n.\tO\n\nContrary\tO\nto\tO\nthe\tO\npublished\tO\nliterature\tO\n,\tO\nthis\tO\ngroup\tO\ndid\tO\nreasonably\tO\nwell\tO\nwith\tO\naggressive\tO\nmanagement\tO\n.\tO\n\nEffect\tO\nof\tO\nintravenous\tO\nnimodipine\tB-Chemical\non\tO\nblood\tO\npressure\tO\nand\tO\noutcome\tO\nafter\tO\nacute\tB-Disease\nstroke\tI-Disease\n.\tO\n\nBACKGROUND\tO\nAND\tO\nPURPOSE\tO\n:\tO\nThe\tO\nIntravenous\tO\nNimodipine\tB-Chemical\nWest\tO\nEuropean\tO\nStroke\tB-Disease\nTrial\tO\n(\tO\nINWEST\tO\n)\tO\nfound\tO\na\tO\ncorrelation\tO\nbetween\tO\nnimodipine\tB-Chemical\n-\tO\ninduced\tO\nreduction\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\n(\tO\nBP\tO\n)\tO\nand\tO\nan\tO\nunfavorable\tO\noutcome\tO\nin\tO\nacute\tB-Disease\nstroke\tI-Disease\n.\tO\n\nWe\tO\nsought\tO\nto\tO\nconfirm\tO\nthis\tO\ncorrelation\tO\nwith\tO\nand\tO\nwithout\tO\nadjustment\tO\nfor\tO\nprognostic\tO\nvariables\tO\nand\tO\nto\tO\ninvestigate\tO\noutcome\tO\nin\tO\nsubgroups\tO\nwith\tO\nincreasing\tO\nlevels\tO\nof\tO\nBP\tB-Disease\nreduction\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nPatients\tO\nwith\tO\na\tO\nclinical\tO\ndiagnosis\tO\nof\tO\nischemic\tB-Disease\nstroke\tI-Disease\n(\tO\nwithin\tO\n24\tO\nhours\tO\n)\tO\nwere\tO\nconsecutively\tO\nallocated\tO\nto\tO\nreceive\tO\nplacebo\tO\n(\tO\nn\tO\n=\tO\n100\tO\n)\tO\n,\tO\n1\tO\nmg\tO\n/\tO\nh\tO\n(\tO\nlow\tO\n-\tO\ndose\tO\n)\tO\nnimodipine\tB-Chemical\n(\tO\nn\tO\n=\tO\n101\tO\n)\tO\n,\tO\nor\tO\n2\tO\nmg\tO\n/\tO\nh\tO\n(\tO\nhigh\tO\n-\tO\ndose\tO\n)\tO\nnimodipine\tB-Chemical\n(\tO\nn\tO\n=\tO\n94\tO\n)\tO\n.\tO\n\nThe\tO\ncorrelation\tO\nbetween\tO\naverage\tO\nBP\tO\nchange\tO\nduring\tO\nthe\tO\nfirst\tO\n2\tO\ndays\tO\nand\tO\nthe\tO\noutcome\tO\nat\tO\nday\tO\n21\tO\nwas\tO\nanalyzed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTwo\tO\nhundred\tO\nsixty\tO\n-\tO\nfive\tO\npatients\tO\nwere\tO\nincluded\tO\nin\tO\nthis\tO\nanalysis\tO\n(\tO\nn\tO\n=\tO\n92\tO\n,\tO\n93\tO\n,\tO\nand\tO\n80\tO\nfor\tO\nplacebo\tO\n,\tO\nlow\tO\ndose\tO\n,\tO\nand\tO\nhigh\tO\ndose\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nNimodipine\tB-Chemical\ntreatment\tO\nresulted\tO\nin\tO\na\tO\nstatistically\tO\nsignificant\tO\nreduction\tB-Disease\nin\tI-Disease\nsystolic\tI-Disease\nBP\tI-Disease\n(\tO\nSBP\tO\n)\tO\nand\tO\ndiastolic\tO\nBP\tO\n(\tO\nDBP\tO\n)\tO\nfrom\tO\nbaseline\tO\ncompared\tO\nwith\tO\nplacebo\tO\nduring\tO\nthe\tO\nfirst\tO\nfew\tO\ndays\tO\n.\tO\n\nIn\tO\nmultivariate\tO\nanalysis\tO\n,\tO\na\tO\nsignificant\tO\ncorrelation\tO\nbetween\tO\nDBP\tB-Disease\nreduction\tI-Disease\nand\tO\nworsening\tO\nof\tO\nthe\tO\nneurological\tO\nscore\tO\nwas\tO\nfound\tO\nfor\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\n(\tO\nbeta\tO\n=\tO\n0\tO\n.\tO\n49\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n048\tO\n)\tO\n.\tO\n\nPatients\tO\nwith\tO\na\tO\nDBP\tB-Disease\nreduction\tI-Disease\nof\tO\n>\tO\nor\tO\n=\tO\n20\tO\n%\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\nhad\tO\na\tO\nsignificantly\tO\nincreased\tO\nadjusted\tO\nOR\tO\nfor\tO\nthe\tO\ncompound\tO\noutcome\tO\nvariable\tO\ndeath\tB-Disease\nor\tO\ndependency\tO\n(\tO\nBarthel\tO\nIndex\tO\n<\tO\n60\tO\n)\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n25\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n10\tO\n.\tO\n16\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n02\tO\nto\tO\n101\tO\n.\tO\n74\tO\n)\tO\nand\tO\ndeath\tB-Disease\nalone\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n9\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n4\tO\n.\tO\n336\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n131\tO\n16\tO\n.\tO\n619\tO\n)\tO\ncompared\tO\nwith\tO\nall\tO\nplacebo\tO\npatients\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n62\tO\n/\tO\n92\tO\nand\tO\n14\tO\n/\tO\n92\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\ncorrelation\tO\nbetween\tO\nSBP\tO\nchange\tO\nand\tO\noutcome\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDBP\tO\n,\tO\nbut\tO\nnot\tO\nSBP\tO\n,\tO\nreduction\tO\nwas\tO\nassociated\tO\nwith\tO\nneurological\tO\nworsening\tO\nafter\tO\nthe\tO\nintravenous\tO\nadministration\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\nnimodipine\tB-Chemical\nafter\tO\nacute\tB-Disease\nstroke\tI-Disease\n.\tO\n\nFor\tO\nlow\tO\n-\tO\ndose\tO\nnimodipine\tB-Chemical\n,\tO\nthe\tO\nresults\tO\nwere\tO\nnot\tO\nconclusive\tO\n.\tO\n\nThese\tO\nresults\tO\ndo\tO\nnot\tO\nconfirm\tO\nor\tO\nexclude\tO\na\tO\nneuroprotective\tO\nproperty\tO\nof\tO\nnimodipine\tB-Chemical\n.\tO\n\nNeonatal\tO\npyridoxine\tB-Chemical\nresponsive\tO\nconvulsions\tB-Disease\ndue\tO\nto\tO\nisoniazid\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\n17\tO\n-\tO\nday\tO\n-\tO\nold\tO\ninfant\tO\non\tO\nisoniazid\tB-Chemical\ntherapy\tO\n13\tO\nmg\tO\n/\tO\nkg\tO\ndaily\tO\nfrom\tO\nbirth\tO\nbecause\tO\nof\tO\nmaternal\tO\ntuberculosis\tB-Disease\nwas\tO\nadmitted\tO\nafter\tO\n4\tO\ndays\tO\nof\tO\nclonic\tB-Disease\nfits\tI-Disease\n.\tO\n\nNo\tO\nunderlying\tO\ninfective\tO\nor\tO\nbiochemical\tO\ncause\tO\ncould\tO\nbe\tO\nfound\tO\n.\tO\n\nThe\tO\nfits\tB-Disease\nceased\tO\nwithin\tO\n4\tO\nhours\tO\nof\tO\nadministering\tO\nintramuscular\tO\npyridoxine\tB-Chemical\n,\tO\nsuggesting\tO\nan\tO\naetiology\tO\nof\tO\npyridoxine\tB-Chemical\ndeficiency\tO\nsecondary\tO\nto\tO\nisoniazid\tB-Chemical\nmedication\tO\n.\tO\n\nKetamine\tB-Chemical\nsedation\tO\nfor\tO\nthe\tO\nreduction\tO\nof\tO\nchildren\tO\n'\tO\ns\tO\nfractures\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThere\tO\nrecently\tO\nhas\tO\nbeen\tO\na\tO\nresurgence\tO\nin\tO\nthe\tO\nutilization\tO\nof\tO\nketamine\tB-Chemical\n,\tO\na\tO\nunique\tO\nanesthetic\tO\n,\tO\nfor\tO\nemergency\tO\n-\tO\ndepartment\tO\nprocedures\tO\nrequiring\tO\nsedation\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nketamine\tB-Chemical\nfor\tO\nsedation\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nchildren\tO\n'\tO\ns\tO\nfractures\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tO\n\nMETHODS\tO\n:\tO\nOne\tO\nhundred\tO\nand\tO\nfourteen\tO\nchildren\tO\n(\tO\naverage\tO\nage\tO\n,\tO\n5\tO\n.\tO\n3\tO\nyears\tO\n;\tO\nrange\tO\n,\tO\ntwelve\tO\nmonths\tO\nto\tO\nten\tO\nyears\tO\nand\tO\nten\tO\nmonths\tO\n)\tO\nwho\tO\nunderwent\tO\nclosed\tO\nreduction\tO\nof\tO\nan\tO\nisolated\tO\nfracture\tB-Disease\nor\tO\ndislocation\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nat\tO\na\tO\nlevel\tO\n-\tO\nI\tO\ntrauma\tB-Disease\ncenter\tO\nwere\tO\nprospectively\tO\nevaluated\tO\n.\tO\n\nKetamine\tB-Chemical\nhydrochloride\tI-Chemical\nwas\tO\nadministered\tO\nintravenously\tO\n(\tO\nat\tO\na\tO\ndose\tO\nof\tO\ntwo\tO\nmilligrams\tO\nper\tO\nkilogram\tO\nof\tO\nbody\tO\nweight\tO\n)\tO\nin\tO\nninety\tO\n-\tO\nnine\tO\nof\tO\nthe\tO\npatients\tO\nand\tO\nintramuscularly\tO\n(\tO\nat\tO\na\tO\ndose\tO\nof\tO\nfour\tO\nmilligrams\tO\nper\tO\nkilogram\tO\nof\tO\nbody\tO\nweight\tO\n)\tO\nin\tO\nthe\tO\nother\tO\nfifteen\tO\n.\tO\n\nA\tO\nboard\tO\n-\tO\ncertified\tO\nemergency\tO\nphysician\tO\nskilled\tO\nin\tO\nairway\tO\nmanagement\tO\nsupervised\tO\nadministration\tO\nof\tO\nthe\tO\nanesthetic\tO\n,\tO\nand\tO\nthe\tO\npatients\tO\nwere\tO\nmonitored\tO\nby\tO\na\tO\nregistered\tO\nnurse\tO\n.\tO\n\nAny\tO\npain\tB-Disease\nduring\tO\nthe\tO\nreduction\tO\nwas\tO\nrated\tO\nby\tO\nthe\tO\northopaedic\tO\nsurgeon\tO\ntreating\tO\nthe\tO\npatient\tO\naccording\tO\nto\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nof\tO\nEastern\tO\nOntario\tO\nPain\tB-Disease\nScale\tO\n(\tO\nCHEOPS\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\naverage\tO\ntime\tO\nfrom\tO\nintravenous\tO\nadministration\tO\nof\tO\nketamine\tB-Chemical\nto\tO\nmanipulation\tO\nof\tO\nthe\tO\nfracture\tB-Disease\nor\tO\ndislocation\tB-Disease\nwas\tO\none\tO\nminute\tO\nand\tO\nthirty\tO\n-\tO\nsix\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\ntwenty\tO\nseconds\tO\nto\tO\nfive\tO\nminutes\tO\n)\tO\n,\tO\nand\tO\nthe\tO\naverage\tO\ntime\tO\nfrom\tO\nintramuscular\tO\nadministration\tO\nto\tO\nmanipulation\tO\nwas\tO\nfour\tO\nminutes\tO\nand\tO\nforty\tO\n-\tO\ntwo\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\nsixty\tO\nseconds\tO\nto\tO\nfifteen\tO\nminutes\tO\n)\tO\n.\tO\n\nThe\tO\naverage\tO\nscore\tO\naccording\tO\nto\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nof\tO\nEastern\tO\nOntario\tO\nPain\tB-Disease\nScale\tO\nwas\tO\n6\tO\n.\tO\n4\tO\npoints\tO\n(\tO\nrange\tO\n,\tO\n5\tO\nto\tO\n10\tO\npoints\tO\n)\tO\n,\tO\nreflecting\tO\nminimal\tO\nor\tO\nno\tO\npain\tB-Disease\nduring\tO\nfracture\tB-Disease\nreduction\tO\n.\tO\n\nAdequate\tO\nfracture\tB-Disease\nreduction\tO\nwas\tO\nobtained\tO\nin\tO\n111\tO\nof\tO\nthe\tO\nchildren\tO\n.\tO\n\nNinety\tO\n-\tO\nnine\tO\npercent\tO\n(\tO\nsixty\tO\n-\tO\neight\tO\n)\tO\nof\tO\nthe\tO\nsixty\tO\n-\tO\nnine\tO\nparents\tO\npresent\tO\nduring\tO\nthe\tO\nreduction\tO\nwere\tO\npleased\tO\nwith\tO\nthe\tO\nsedation\tO\nand\tO\nwould\tO\nallow\tO\nit\tO\nto\tO\nbe\tO\nused\tO\nagain\tO\nin\tO\na\tO\nsimilar\tO\nsituation\tO\n.\tO\n\nPatency\tO\nof\tO\nthe\tO\nairway\tO\nand\tO\nindependent\tO\nrespiration\tO\nwere\tO\nmaintained\tO\nin\tO\nall\tO\nof\tO\nthe\tO\npatients\tO\n.\tO\n\nBlood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\nremained\tO\nstable\tO\n.\tO\n\nMinor\tO\nside\tO\neffects\tO\nincluded\tO\nnausea\tB-Disease\n(\tO\nthirteen\tO\npatients\tO\n)\tO\n,\tO\nemesis\tB-Disease\n(\tO\neight\tO\nof\tO\nthe\tO\nthirteen\tO\npatients\tO\nwith\tO\nnausea\tB-Disease\n)\tO\n,\tO\nclumsiness\tB-Disease\n(\tO\nevident\tO\nas\tO\nataxic\tB-Disease\nmovements\tI-Disease\nin\tO\nten\tO\npatients\tO\n)\tO\n,\tO\nand\tO\ndysphoric\tB-Disease\nreaction\tI-Disease\n(\tO\none\tO\npatient\tO\n)\tO\n.\tO\n\nNo\tO\nlong\tO\n-\tO\nterm\tO\nsequelae\tO\nwere\tO\nnoted\tO\n,\tO\nand\tO\nno\tO\npatients\tO\nhad\tO\nhallucinations\tB-Disease\nor\tO\nnightmares\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nKetamine\tB-Chemical\nreliably\tO\n,\tO\nsafely\tO\n,\tO\nand\tO\nquickly\tO\nprovided\tO\nadequate\tO\nsedation\tO\nto\tO\neffectively\tO\nfacilitate\tO\nthe\tO\nreduction\tO\nof\tO\nchildren\tO\n'\tO\ns\tO\nfractures\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nat\tO\nour\tO\ninstitution\tO\n.\tO\n\nKetamine\tB-Chemical\nshould\tO\nonly\tO\nbe\tO\nused\tO\nin\tO\nan\tO\nenvironment\tO\nsuch\tO\nas\tO\nthe\tO\nemergency\tO\ndepartment\tO\n,\tO\nwhere\tO\nproper\tO\none\tO\n-\tO\non\tO\n-\tO\none\tO\nmonitoring\tO\nis\tO\nused\tO\nand\tO\nboard\tO\n-\tO\ncertified\tO\nphysicians\tO\nskilled\tO\nin\tO\nairway\tO\nmanagement\tO\nare\tO\ndirectly\tO\ninvolved\tO\nin\tO\nthe\tO\ncare\tO\nof\tO\nthe\tO\npatient\tO\n.\tO\n\nCyclosporine\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\n-\tO\nassociated\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n(\tO\nTMA\tB-Disease\n)\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\ncyclosporine\tB-Chemical\nhas\tO\nbeen\tO\nwell\tO\ndocumented\tO\n.\tO\n\nTreatments\tO\nhave\tO\nincluded\tO\ndiscontinuation\tO\nor\tO\nreduction\tO\nof\tO\ncyclosporine\tB-Chemical\ndose\tO\nwith\tO\nor\tO\nwithout\tO\nconcurrent\tO\nplasma\tO\nexchange\tO\n,\tO\nplasma\tO\ninfusion\tO\n,\tO\nanticoagulation\tO\n,\tO\nand\tO\nintravenous\tO\nimmunoglobulin\tO\nG\tO\ninfusion\tO\n.\tO\n\nHowever\tO\n,\tO\nfor\tO\nrecipients\tO\nof\tO\norgan\tO\ntransplantation\tO\n,\tO\nremoving\tO\nthe\tO\ninciting\tO\nagent\tO\nis\tO\nnot\tO\nwithout\tO\nthe\tO\nattendant\tO\nrisk\tO\nof\tO\nprecipitating\tO\nacute\tO\nrejection\tO\nand\tO\ngraft\tO\nloss\tO\n.\tO\n\nThe\tO\nlast\tO\ndecade\tO\nhas\tO\nseen\tO\nthe\tO\nemergence\tO\nof\tO\ntacrolimus\tB-Chemical\nas\tO\na\tO\npotent\tO\nimmunosuppressive\tO\nagent\tO\nwith\tO\nmechanisms\tO\nof\tO\naction\tO\nvirtually\tO\nidentical\tO\nto\tO\nthose\tO\nof\tO\ncyclosporine\tB-Chemical\n.\tO\n\nAs\tO\na\tO\nresult\tO\n,\tO\nswitching\tO\nto\tO\ntacrolimus\tB-Chemical\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nbe\tO\na\tO\nviable\tO\ntherapeutic\tO\noption\tO\nin\tO\nthe\tO\nsetting\tO\nof\tO\ncyclosporine\tB-Chemical\n-\tO\ninduced\tO\nTMA\tB-Disease\n.\tO\n\nWith\tO\nthe\tO\nmore\tO\nwidespread\tO\napplication\tO\nof\tO\ntacrolimus\tB-Chemical\nin\tO\norgan\tO\ntransplantation\tO\n,\tO\ntacrolimus\tB-Chemical\n-\tO\nassociated\tO\nTMA\tB-Disease\nhas\tO\nalso\tO\nbeen\tO\nrecognized\tO\n.\tO\n\nHowever\tO\n,\tO\nliterature\tO\nregarding\tO\nthe\tO\nincidence\tO\nof\tO\nthe\tO\nrecurrence\tO\nof\tO\nTMA\tB-Disease\nin\tO\npatients\tO\nexposed\tO\nsequentially\tO\nto\tO\ncyclosporine\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\nis\tO\nlimited\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\nliving\tO\ndonor\tO\nrenal\tO\ntransplant\tO\nrecipient\tO\nwho\tO\ndeveloped\tO\ncyclosporine\tB-Chemical\n-\tO\ninduced\tO\nTMA\tB-Disease\nthat\tO\nresponded\tO\nto\tO\nthe\tO\nwithdrawal\tO\nof\tO\ncyclosporine\tB-Chemical\nin\tO\nconjunction\tO\nwith\tO\nplasmapheresis\tO\nand\tO\nfresh\tO\nfrozen\tO\nplasma\tO\nreplacement\tO\ntherapy\tO\n.\tO\n\nIntroduction\tO\nof\tO\ntacrolimus\tB-Chemical\nas\tO\nan\tO\nalternative\tO\nimmunosuppressive\tO\nagent\tO\nresulted\tO\nin\tO\nthe\tO\nrecurrence\tO\nof\tO\nTMA\tB-Disease\nand\tO\nthe\tO\nsubsequent\tO\nloss\tO\nof\tO\nthe\tO\nrenal\tO\nallograft\tO\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\nswitched\tO\nfrom\tO\ncyclosporine\tB-Chemical\nto\tO\ntacrolimus\tB-Chemical\nor\tO\nvice\tO\nversa\tO\nshould\tO\nbe\tO\nclosely\tO\nmonitored\tO\nfor\tO\nthe\tO\nsigns\tO\nand\tO\nsymptoms\tO\nof\tO\nrecurrent\tO\nTMA\tB-Disease\n.\tO\n\nAnalgesic\tO\neffect\tO\nof\tO\nintravenous\tO\nketamine\tB-Chemical\nin\tO\ncancer\tB-Disease\npatients\tO\non\tO\nmorphine\tB-Chemical\ntherapy\tO\n:\tO\na\tO\nrandomized\tO\n,\tO\ncontrolled\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nPain\tB-Disease\nnot\tO\nresponsive\tO\nto\tO\nmorphine\tB-Chemical\nis\tO\noften\tO\nproblematic\tO\n.\tO\n\nAnimal\tO\nand\tO\nclinical\tO\nstudies\tO\nhave\tO\nsuggested\tO\nthat\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nantagonists\tO\n,\tO\nsuch\tO\nas\tO\nketamine\tB-Chemical\n,\tO\nmay\tO\nbe\tO\neffective\tO\nin\tO\nimproving\tO\nopioid\tO\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tB-Disease\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tB-Disease\npain\tI-Disease\n.\tO\n\nA\tO\nslow\tO\nbolus\tO\nof\tO\nsubhypnotic\tO\ndoses\tO\nof\tO\nketamine\tB-Chemical\n(\tO\n0\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nor\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ngiven\tO\nto\tO\n10\tO\ncancer\tB-Disease\npatients\tO\nwhose\tO\npain\tB-Disease\nwas\tO\nunrelieved\tO\nby\tO\nmorphine\tB-Chemical\nin\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nPain\tB-Disease\nintensity\tO\non\tO\na\tO\n0\tO\nto\tO\n10\tO\nnumerical\tO\nscale\tO\n;\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\n,\tO\ndrowsiness\tO\n,\tO\nconfusion\tB-Disease\n,\tO\nand\tO\ndry\tB-Disease\nmouth\tI-Disease\n,\tO\nusing\tO\na\tO\nscale\tO\nfrom\tO\n0\tO\nto\tO\n3\tO\n(\tO\nnot\tO\nat\tO\nall\tO\n,\tO\nslight\tO\n,\tO\na\tO\nlot\tO\n,\tO\nawful\tO\n)\tO\n;\tO\nMini\tO\n-\tO\nMental\tO\nState\tO\nExamination\tO\n(\tO\nMMSE\tO\n)\tO\n(\tO\n0\tO\n-\tO\n30\tO\n)\tO\n;\tO\nand\tO\narterial\tO\npressure\tO\nwere\tO\nrecorded\tO\nbefore\tO\nadministration\tO\nof\tO\ndrugs\tO\n(\tO\nT0\tO\n)\tO\nand\tO\nafter\tO\n30\tO\nminutes\tO\n(\tO\nT30\tO\n)\tO\n,\tO\n60\tO\nminutes\tO\n(\tO\nT60\tO\n)\tO\n,\tO\n120\tO\nminutes\tO\n(\tO\nT120\tO\n)\tO\n,\tO\nand\tO\n180\tO\nminutes\tO\n(\tO\nT180\tO\n)\tO\n.\tO\n\nKetamine\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nsaline\tO\nsolution\tO\n,\tO\nsignificantly\tO\nreduced\tO\nthe\tO\npain\tB-Disease\nintensity\tO\nin\tO\nalmost\tO\nall\tO\nthe\tO\npatients\tO\nat\tO\nboth\tO\ndoses\tO\n.\tO\n\nThis\tO\neffect\tO\nwas\tO\nmore\tO\nrelevant\tO\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nhigher\tO\ndoses\tO\n.\tO\n\nHallucinations\tB-Disease\noccurred\tO\nin\tO\n4\tO\npatients\tO\n,\tO\nand\tO\nan\tO\nunpleasant\tO\nsensation\tO\n(\tO\n\"\tO\nempty\tO\nhead\tO\n\"\tO\n)\tO\nwas\tO\nalso\tO\nreported\tO\nby\tO\n2\tO\npatients\tO\n.\tO\n\nThese\tO\nepisodes\tO\nreversed\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\ndiazepam\tB-Chemical\n1\tO\nmg\tO\nintravenously\tO\n.\tO\n\nSignificant\tO\nincreases\tO\nin\tO\ndrowsiness\tO\nwere\tO\nreported\tO\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nketamine\tB-Chemical\nin\tO\nboth\tO\ngroups\tO\nand\tO\nwere\tO\nmore\tO\nmarked\tO\nwith\tO\nketamine\tB-Chemical\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nA\tO\nsignificant\tO\ndifference\tO\nin\tO\nMMSE\tO\nwas\tO\nobserved\tO\nat\tO\nT30\tO\nin\tO\npatients\tO\nwho\tO\nreceived\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nof\tO\nketamine\tB-Chemical\n.\tO\n\nKetamine\tB-Chemical\ncan\tO\nimprove\tO\nmorphine\tB-Chemical\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tB-Disease\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tB-Disease\npain\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\noccurrence\tO\nof\tO\ncentral\tO\nadverse\tO\neffects\tO\nshould\tO\nbe\tO\ntaken\tO\ninto\tO\naccount\tO\n,\tO\nespecially\tO\nwhen\tO\nusing\tO\nhigher\tO\ndoses\tO\n.\tO\n\nThis\tO\nobservation\tO\nshould\tO\nbe\tO\ntested\tO\nin\tO\nstudies\tO\nof\tO\nprolonged\tO\nketamine\tB-Chemical\nadministration\tO\n.\tO\n\nPaclitaxel\tB-Chemical\n,\tO\ncisplatin\tB-Chemical\n,\tO\nand\tO\ngemcitabine\tB-Chemical\ncombination\tO\nchemotherapy\tO\nwithin\tO\na\tO\nmultidisciplinary\tO\ntherapeutic\tO\napproach\tO\nin\tO\nmetastatic\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nCisplatin\tB-Chemical\n-\tO\nbased\tO\nchemotherapy\tO\ncombinations\tO\nimprove\tO\nquality\tO\nof\tO\nlife\tO\nand\tO\nsurvival\tO\nin\tO\nadvanced\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\n(\tO\nNSCLC\tB-Disease\n)\tO\n.\tO\n\nThe\tO\nemergence\tO\nof\tO\nnew\tO\nactive\tO\ndrugs\tO\nmight\tO\ntranslate\tO\ninto\tO\nmore\tO\neffective\tO\nregimens\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nthis\tO\ndisease\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\nfeasibility\tO\n,\tO\nresponse\tO\nrate\tO\n,\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\na\tO\npaclitaxel\tB-Chemical\n,\tO\ncisplatin\tB-Chemical\n,\tO\nand\tO\ngemcitabine\tB-Chemical\ncombination\tO\nto\tO\ntreat\tO\nmetastatic\tO\nNSCLC\tB-Disease\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\nconsecutive\tO\nchemotherapy\tO\n-\tO\nnaive\tO\npatients\tO\nwith\tO\nStage\tO\nIV\tO\nNSCLC\tB-Disease\nand\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nperformance\tO\nstatus\tO\nof\tO\n0\tO\n-\tO\n2\tO\nwere\tO\ntreated\tO\nwith\tO\na\tO\ncombination\tO\nof\tO\npaclitaxel\tB-Chemical\n(\tO\n135\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n3\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\ncisplatin\tB-Chemical\n(\tO\n120\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n6\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\nand\tO\ngemcitabine\tB-Chemical\n(\tO\n800\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n30\tO\nminutes\tO\n)\tO\non\tO\nDays\tO\n1\tO\nand\tO\n8\tO\n,\tO\nevery\tO\n4\tO\nweeks\tO\n.\tO\n\nAlthough\tO\nresponding\tO\npatients\tO\nwere\tO\nscheduled\tO\nto\tO\nreceive\tO\nconsolidation\tO\nradiotherapy\tO\nand\tO\n24\tO\npatients\tO\nreceived\tO\npreplanned\tO\nsecond\tO\n-\tO\nline\tO\nchemotherapy\tO\nafter\tO\ndisease\tO\nprogression\tO\n,\tO\nthe\tO\nresponse\tO\nand\tO\ntoxicity\tB-Disease\nrates\tO\nreported\tO\nrefer\tO\nonly\tO\nto\tO\nthe\tO\nchemotherapy\tO\nregimen\tO\ngiven\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\nthe\tO\npatients\tO\nwere\tO\nexamined\tO\nfor\tO\ntoxicity\tB-Disease\n;\tO\n34\tO\nwere\tO\nexaminable\tO\nfor\tO\nresponse\tO\n.\tO\n\nAn\tO\nobjective\tO\nresponse\tO\nwas\tO\nobserved\tO\nin\tO\n73\tO\n.\tO\n5\tO\n%\tO\nof\tO\nthe\tO\npatients\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n,\tO\n55\tO\n.\tO\n6\tO\n-\tO\n87\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nincluding\tO\n4\tO\ncomplete\tO\nresponses\tO\n(\tO\n11\tO\n.\tO\n7\tO\n%\tO\n)\tO\n.\tO\n\nAccording\tO\nto\tO\nintention\tO\n-\tO\nto\tO\n-\tO\ntreat\tO\n,\tO\nthe\tO\noverall\tO\nresponse\tO\nrate\tO\nwas\tO\n71\tO\n.\tO\n4\tO\n%\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n53\tO\n.\tO\n7\tO\n-\tO\n85\tO\n.\tO\n4\tO\n%\tO\n)\tO\n.\tO\n\nAfter\tO\n154\tO\ncourses\tO\nof\tO\ntherapy\tO\n,\tO\nthe\tO\nmedian\tO\ndose\tO\nintensity\tO\nwas\tO\n131\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\npaclitaxel\tB-Chemical\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\n117\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\ncisplatin\tB-Chemical\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nand\tO\n1378\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\ngemcitabine\tB-Chemical\n(\tO\n86\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nWorld\tO\nHealth\tO\nOrganization\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tB-Disease\nand\tO\nthrombocytopenia\tB-Disease\noccurred\tO\nin\tO\n39\tO\n.\tO\n9\tO\n%\tO\nand\tO\n11\tO\n.\tO\n4\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nrespectively\tO\n.\tO\n\nThere\tO\nwas\tO\none\tO\ntreatment\tO\n-\tO\nrelated\tO\ndeath\tB-Disease\n.\tO\n\nNonhematologic\tO\ntoxicities\tB-Disease\nwere\tO\nmild\tO\n.\tO\n\nAfter\tO\na\tO\nmedian\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n22\tO\nmonths\tO\n,\tO\nthe\tO\nmedian\tO\nprogression\tO\nfree\tO\nsurvival\tO\nrate\tO\nwas\tO\n7\tO\nmonths\tO\n,\tO\nand\tO\nthe\tO\nmedian\tO\nsurvival\tO\ntime\tO\nwas\tO\n16\tO\nmonths\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tO\nof\tO\npaclitaxel\tB-Chemical\n,\tO\ncisplatin\tB-Chemical\n,\tO\nand\tO\ngemcitabine\tB-Chemical\nis\tO\nwell\tO\ntolerated\tO\nand\tO\nshows\tO\nhigh\tO\nactivity\tO\nin\tO\nmetastatic\tO\nNSCLC\tB-Disease\n.\tO\n\nThis\tO\ntreatment\tO\nmerits\tO\nfurther\tO\ncomparison\tO\nwith\tO\nother\tO\ncisplatin\tB-Chemical\n-\tO\nbased\tO\nregimens\tO\n.\tO\n\nSerotonergic\tB-Chemical\nantidepressants\tI-Chemical\nand\tO\nurinary\tB-Disease\nincontinence\tI-Disease\n.\tO\n\nMany\tO\nnew\tO\nserotonergic\tB-Chemical\nantidepressants\tI-Chemical\nhave\tO\nbeen\tO\nintroduced\tO\nover\tO\nthe\tO\npast\tO\ndecade\tO\n.\tO\n\nAlthough\tO\nurinary\tB-Disease\nincontinence\tI-Disease\nis\tO\nlisted\tO\nas\tO\none\tO\nside\tO\neffect\tO\nof\tO\nthese\tO\ndrugs\tO\nin\tO\ntheir\tO\npackage\tO\ninserts\tO\nthere\tO\nis\tO\nonly\tO\none\tO\nreport\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nThis\tO\nconcerns\tO\n2\tO\nmale\tO\npatients\tO\nwho\tO\nexperienced\tO\nincontinence\tB-Disease\nwhile\tO\ntaking\tO\nvenlafaxine\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\npaper\tO\nthe\tO\nauthors\tO\ndescribe\tO\n2\tO\nfemale\tO\npatients\tO\nwho\tO\ndeveloped\tO\nincontinence\tB-Disease\nsecondary\tO\nto\tO\nthe\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitors\tO\nparoxetine\tB-Chemical\nand\tO\nsertraline\tB-Chemical\n,\tO\nas\tO\nwell\tO\nas\tO\na\tO\nthird\tO\nwho\tO\ndeveloped\tO\nthis\tO\nside\tO\neffect\tO\non\tO\nvenlafaxine\tB-Chemical\n.\tO\n\nIn\tO\n2\tO\nof\tO\nthe\tO\n3\tO\ncases\tO\nthe\tO\npatients\tO\nwere\tO\nalso\tO\ntaking\tO\nlithium\tB-Chemical\ncarbonate\tI-Chemical\nand\tO\nbeta\tO\n-\tO\nblockers\tO\n,\tO\nboth\tO\nof\tO\nwhich\tO\ncould\tO\nhave\tO\ncontributed\tO\nto\tO\nthe\tO\nincontinence\tB-Disease\n.\tO\n\nAnimal\tO\nstudies\tO\nsuggest\tO\nthat\tO\nincontinence\tB-Disease\nsecondary\tO\nto\tO\nserotonergic\tB-Chemical\nantidepressants\tI-Chemical\ncould\tO\nbe\tO\nmediated\tO\nby\tO\nthe\tO\n5HT4\tO\nreceptors\tO\nfound\tO\non\tO\nthe\tO\nbladder\tO\n.\tO\n\nFurther\tO\nresearch\tO\nis\tO\nneeded\tO\nto\tO\ndelineate\tO\nthe\tO\nfrequency\tO\nof\tO\nthis\tO\ntroubling\tO\nside\tO\neffect\tO\nand\tO\nhow\tO\nbest\tO\nto\tO\ntreat\tO\nit\tO\n.\tO\n\nAcute\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n:\tO\ndifferential\tO\nsensitivity\tO\nof\tO\nsix\tO\ninbred\tO\nmouse\tO\nstrains\tO\n.\tO\n\nMature\tO\nmale\tO\nand\tO\nfemale\tO\nmice\tO\nfrom\tO\nsix\tO\ninbred\tO\nstains\tO\nwere\tO\ntested\tO\nfor\tO\nsusceptibility\tO\nto\tO\nbehavioral\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nCocaine\tB-Chemical\nwas\tO\ninjected\tO\nip\tO\nover\tO\na\tO\nrange\tO\nof\tO\ndoses\tO\n(\tO\n50\tO\n-\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\nbehavior\tO\nwas\tO\nmonitored\tO\nfor\tO\n20\tO\nminutes\tO\n.\tO\n\nSeizure\tB-Disease\nend\tO\npoints\tO\nincluded\tO\nlatency\tO\nto\tO\nforelimb\tO\nor\tO\nhindlimb\tO\nclonus\tO\n,\tO\nlatency\tO\nto\tO\nclonic\tO\nrunning\tO\nseizure\tB-Disease\nand\tO\nlatency\tO\nto\tO\njumping\tO\nbouncing\tO\nseizure\tB-Disease\n.\tO\n\nA\tO\nrange\tO\nof\tO\nstrain\tO\nspecific\tO\nsensitivities\tO\nwas\tO\ndocumented\tO\nwith\tO\nA\tO\n/\tO\nJ\tO\nand\tO\nSJL\tO\nmice\tO\nbeing\tO\nmost\tO\nsensitive\tO\nand\tO\nC57BL\tO\n/\tO\n6J\tO\nmost\tO\nresistant\tO\n.\tO\n\nDBA\tO\n/\tO\n2J\tO\n,\tO\nBALB\tO\n/\tO\ncByJ\tO\nand\tO\nNZW\tO\n/\tO\nLacJ\tO\nstrains\tO\nexhibited\tO\nintermediate\tO\nsensitivity\tO\n.\tO\n\nEEG\tO\nrecordings\tO\nwere\tO\nmade\tO\nin\tO\nSJL\tO\n,\tO\nA\tO\n/\tO\nJ\tO\nand\tO\nC57BL\tO\n/\tO\n6J\tO\nmice\tO\nrevealing\tO\na\tO\nclose\tO\ncorrespondence\tO\nbetween\tO\nelectrical\tO\nactivity\tO\nand\tO\nbehavior\tO\n.\tO\n\nAdditionally\tO\n,\tO\nlevels\tO\nof\tO\ncocaine\tB-Chemical\ndetermined\tO\nin\tO\nhippocampus\tO\nand\tO\ncortex\tO\nwere\tO\nnot\tO\ndifferent\tO\nbetween\tO\nsensitive\tO\nand\tO\nresistant\tO\nstrains\tO\n.\tO\n\nAdditional\tO\nstudies\tO\nof\tO\nthese\tO\nmurine\tO\nstrains\tO\nmay\tO\nbe\tO\nuseful\tO\nfor\tO\ninvestigating\tO\ngenetic\tO\ninfluences\tO\non\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nHypotension\tB-Disease\nfollowing\tO\nthe\tO\ninitiation\tO\nof\tO\ntizanidine\tB-Chemical\nin\tO\na\tO\npatient\tO\ntreated\tO\nwith\tO\nan\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitor\tO\nfor\tO\nchronic\tO\nhypertension\tB-Disease\n.\tO\n\nCentrally\tO\nacting\tO\nalpha\tO\n-\tO\n2\tO\nadrenergic\tO\nagonists\tO\nare\tO\none\tO\nof\tO\nseveral\tO\npharmacologic\tO\nagents\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nspasticity\tB-Disease\nrelated\tO\nto\tO\ndisorders\tB-Disease\nof\tI-Disease\nthe\tI-Disease\ncentral\tI-Disease\nnervous\tI-Disease\nsystem\tI-Disease\n.\tO\n\nIn\tO\naddition\tO\nto\tO\ntheir\tO\neffects\tO\non\tO\nspasticity\tB-Disease\n,\tO\ncertain\tO\nadverse\tO\ncardiorespiratory\tO\neffects\tO\nhave\tO\nbeen\tO\nreported\tO\n.\tO\n\nAdults\tO\nchronically\tO\ntreated\tO\nwith\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitors\tO\nmay\tO\nhave\tO\na\tO\nlimited\tO\nability\tO\nto\tO\nrespond\tO\nto\tO\nhypotension\tB-Disease\nwhen\tO\nthe\tO\nsympathetic\tO\nresponse\tO\nis\tO\nsimultaneously\tO\nblocked\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\n10\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nchronically\tO\ntreated\tO\nwith\tO\nlisinopril\tB-Chemical\n,\tO\nan\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitor\tO\n,\tO\nto\tO\ncontrol\tO\nhypertension\tB-Disease\nwho\tO\ndeveloped\tO\nhypotension\tB-Disease\nfollowing\tO\nthe\tO\naddition\tO\nof\tO\ntizanidine\tB-Chemical\n,\tO\nan\tO\nalpha\tO\n-\tO\n2\tO\nagonist\tO\n,\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nspasticity\tB-Disease\n.\tO\n\nThe\tO\npossible\tO\ninteraction\tO\nof\tO\ntizanidine\tB-Chemical\nand\tO\nother\tO\nantihypertensive\tO\nagents\tO\nshould\tO\nbe\tO\nkept\tO\nin\tO\nmind\tO\nwhen\tO\nprescribing\tO\ntherapy\tO\nto\tO\ntreat\tO\neither\tO\nhypertension\tB-Disease\nor\tO\nspasticity\tB-Disease\nin\tO\nsuch\tO\npatients\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nselected\tO\nfor\tO\ndifferential\tO\nsensitivities\tO\nto\tO\nbeta\tB-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nare\tO\nalso\tO\ndifferentially\tO\nsensitive\tO\nto\tO\nvarious\tO\npharmacological\tO\neffects\tO\nof\tO\nother\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tO\nligands\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nwere\tO\nselectively\tO\nbred\tO\naccording\tO\nto\tO\ntheir\tO\nsensitivity\tO\n(\tO\nBS\tO\nline\tO\n)\tO\nor\tO\nresistance\tO\n(\tO\nBR\tO\nline\tO\n)\tO\nto\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\na\tO\nsingle\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tO\nof\tO\nmethyl\tB-Chemical\nbeta\tI-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\ncarboxylate\tI-Chemical\n(\tO\nbeta\tB-Chemical\n-\tI-Chemical\nCCM\tI-Chemical\n)\tO\n,\tO\nan\tO\ninverse\tO\nagonist\tO\nof\tO\nthe\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tO\nbenzodiazepine\tB-Chemical\nsite\tO\n.\tO\n\nOur\tO\naim\tO\nwas\tO\nto\tO\ncharacterize\tO\nboth\tO\nlines\tO\n'\tO\nsensitivities\tO\nto\tO\nvarious\tO\nphysiological\tO\neffects\tO\nof\tO\nother\tO\nligands\tO\nof\tO\nthe\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tO\n.\tO\n\nWe\tO\nmeasured\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\nanxiolysis\tO\nwith\tO\nthe\tO\nelevated\tO\nplus\tO\n-\tO\nmaze\tO\ntest\tO\n,\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\nsedation\tO\nby\tO\nrecording\tO\nthe\tO\nvigilance\tO\nstates\tO\n,\tO\nand\tO\npicrotoxin\tB-Chemical\n-\tO\nand\tO\npentylenetetrazol\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nafter\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\n.\tO\n\nResults\tO\npresented\tO\nhere\tO\nshow\tO\nthat\tO\nthe\tO\ndifferential\tO\nsensitivities\tO\nof\tO\nBS\tO\nand\tO\nBR\tO\nlines\tO\nto\tO\nbeta\tB-Chemical\n-\tI-Chemical\nCCM\tI-Chemical\ncan\tO\nbe\tO\nextended\tO\nto\tO\ndiazepam\tB-Chemical\n,\tO\npicrotoxin\tB-Chemical\n,\tO\nand\tO\npentylenetetrazol\tB-Chemical\n,\tO\nsuggesting\tO\na\tO\ngenetic\tO\nselection\tO\nof\tO\na\tO\ngeneral\tO\nsensitivity\tO\nand\tO\nresistance\tO\nto\tO\nseveral\tO\nligands\tO\nof\tO\nthe\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tO\n.\tO\n\nPropylthiouracil\tB-Chemical\n-\tO\ninduced\tO\nperinuclear\tO\n-\tO\nstaining\tO\nantineutrophil\tO\ncytoplasmic\tO\nautoantibody\tO\n-\tO\npositive\tO\nvasculitis\tB-Disease\nin\tO\nconjunction\tO\nwith\tO\npericarditis\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\npropylthiouracil\tB-Chemical\n-\tO\ninduced\tO\nvasculitis\tB-Disease\nmanifesting\tO\nwith\tO\npericarditis\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\npresent\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\na\tO\nwoman\tO\nwith\tO\nhyperthyroidism\tB-Disease\ntreated\tO\nwith\tO\npropylthiouracil\tB-Chemical\nin\tO\nwhom\tO\na\tO\nsyndrome\tO\nof\tO\npericarditis\tB-Disease\n,\tO\nfever\tB-Disease\n,\tO\nand\tO\nglomerulonephritis\tB-Disease\ndeveloped\tO\n.\tO\n\nSerologic\tO\ntesting\tO\nand\tO\nimmunologic\tO\nstudies\tO\nwere\tO\ndone\tO\n,\tO\nand\tO\na\tO\npericardial\tO\nbiopsy\tO\nwas\tO\nperformed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\nhad\tO\na\tO\nfebrile\tB-Disease\nillness\tI-Disease\nand\tO\nevidence\tO\nof\tO\npericarditis\tB-Disease\n,\tO\nwhich\tO\nwas\tO\nconfirmed\tO\nby\tO\nbiopsy\tO\n.\tO\n\nSerologic\tO\nevaluation\tO\nrevealed\tO\nthe\tO\npresence\tO\nof\tO\nperinuclear\tO\n-\tO\nstaining\tO\nantineutrophil\tO\ncytoplasmic\tO\nautoantibodies\tO\n(\tO\npANCA\tO\n)\tO\nagainst\tO\nmyeloperoxidase\tO\n(\tO\nMPO\tO\n)\tO\n.\tO\n\nPropylthiouracil\tB-Chemical\ntherapy\tO\nwas\tO\nwithdrawn\tO\n,\tO\nand\tO\nshe\tO\nwas\tO\ntreated\tO\nwith\tO\na\tO\n1\tO\n-\tO\nmonth\tO\ncourse\tO\nof\tO\nprednisone\tB-Chemical\n,\tO\nwhich\tO\nalleviated\tO\nher\tO\nsymptoms\tO\n.\tO\n\nA\tO\nliterature\tO\nreview\tO\nrevealed\tO\nno\tO\nprior\tO\nreports\tO\nof\tO\npericarditis\tB-Disease\nin\tO\nanti\tO\n-\tO\nMPO\tO\npANCA\tO\n-\tO\npositive\tO\nvasculitis\tB-Disease\nassociated\tO\nwith\tO\npropylthio\tB-Chemical\n-\tI-Chemical\nuracil\tI-Chemical\ntherapy\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nPericarditis\tB-Disease\nmay\tO\nbe\tO\nthe\tO\ninitial\tO\nmanifestation\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nvasculitis\tB-Disease\nattributable\tO\nto\tO\npropylthio\tB-Chemical\n-\tI-Chemical\nuracil\tI-Chemical\ntherapy\tO\n.\tO\n\nRepeated\tO\ntransient\tO\nanuria\tB-Disease\nfollowing\tO\nlosartan\tB-Chemical\nadministration\tO\nin\tO\na\tO\npatient\tO\nwith\tO\na\tO\nsolitary\tO\nkidney\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n70\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nhypertensive\tB-Disease\nman\tO\nwith\tO\na\tO\nsolitary\tO\nkidney\tO\nand\tO\nchronic\tB-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\nwho\tO\ndeveloped\tO\ntwo\tO\nepisodes\tO\nof\tO\ntransient\tO\nanuria\tB-Disease\nafter\tO\nlosartan\tB-Chemical\nadministration\tO\n.\tO\n\nHe\tO\nwas\tO\nhospitalized\tO\nfor\tO\na\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwith\tO\npulmonary\tB-Disease\nedema\tI-Disease\n,\tO\ntreated\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\ndiuretics\tO\n.\tO\n\nDue\tO\nto\tO\nsevere\tO\nsystolic\tB-Disease\ndysfunction\tI-Disease\nlosartan\tB-Chemical\nwas\tO\nprescribed\tO\n.\tO\n\nSurprisingly\tO\n,\tO\nthe\tO\nfirst\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\nof\tO\nlosartan\tB-Chemical\nresulted\tO\nin\tO\na\tO\nsudden\tO\nanuria\tB-Disease\n,\tO\nwhich\tO\nlasted\tO\neight\tO\nhours\tO\ndespite\tO\nhigh\tO\n-\tO\ndose\tO\nfurosemide\tB-Chemical\nand\tO\namine\tB-Chemical\ninfusion\tO\n.\tO\n\nOne\tO\nweek\tO\nlater\tO\n,\tO\nby\tO\nmistake\tO\n,\tO\nlosartan\tB-Chemical\nwas\tO\nprescribed\tO\nagain\tO\nand\tO\nafter\tO\nthe\tO\nsecond\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\n,\tO\nthe\tO\npatient\tO\ndeveloped\tO\na\tO\nsecond\tO\nepisode\tO\nof\tO\ntransient\tO\nanuria\tB-Disease\nlasting\tO\n10\tO\nhours\tO\n.\tO\n\nDuring\tO\nthese\tO\ntwo\tO\nepisodes\tO\n,\tO\nhis\tO\nblood\tO\npressure\tO\ndiminished\tO\nbut\tO\nno\tO\nsevere\tO\nhypotension\tB-Disease\nwas\tO\nnoted\tO\n.\tO\n\nUltimately\tO\n,\tO\nan\tO\narteriography\tO\nshowed\tO\na\tO\n70\tO\n-\tO\n80\tO\n%\tO\nrenal\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\n.\tO\n\nIn\tO\nthis\tO\npatient\tO\n,\tO\nrenal\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\ncombined\tO\nwith\tO\nheart\tB-Disease\nfailure\tI-Disease\nand\tO\ndiuretic\tO\ntherapy\tO\ncertainly\tO\nresulted\tO\nin\tO\na\tO\nstrong\tO\nactivation\tO\nof\tO\nthe\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\n(\tO\nRAS\tO\n)\tO\n.\tO\n\nUnder\tO\nsuch\tO\nconditions\tO\n,\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\nblockade\tO\nby\tO\nlosartan\tB-Chemical\nprobably\tO\ninduced\tO\na\tO\ncritical\tO\nfall\tO\nin\tO\nglomerular\tO\nfiltration\tO\npressure\tO\n.\tO\n\nThis\tO\ncase\tO\nreport\tO\nhighlights\tO\nthe\tO\nfact\tO\nthat\tO\nthe\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\nantagonist\tO\nlosartan\tB-Chemical\ncan\tO\ncause\tO\nserious\tO\nunexpected\tO\ncomplications\tO\nin\tO\npatients\tO\nwith\tO\nrenovascular\tB-Disease\ndisease\tI-Disease\nand\tO\nshould\tO\nbe\tO\nused\tO\nwith\tO\nextreme\tO\ncaution\tO\nin\tO\nthis\tO\nsetting\tO\n.\tO\n\nCalcineurin\tO\n-\tO\ninhibitor\tO\ninduced\tO\npain\tB-Disease\nsyndrome\tO\n(\tO\nCIPS\tB-Disease\n)\tO\n:\tO\na\tO\nsevere\tO\ndisabling\tO\ncomplication\tO\nafter\tO\norgan\tO\ntransplantation\tO\n.\tO\n\nBone\tO\npain\tB-Disease\nafter\tO\ntransplantation\tO\nis\tO\na\tO\nfrequent\tO\ncomplication\tO\nthat\tO\ncan\tO\nbe\tO\ncaused\tO\nby\tO\nseveral\tO\ndiseases\tO\n.\tO\n\nTreatment\tO\nstrategies\tO\ndepend\tO\non\tO\nthe\tO\ncorrect\tO\ndiagnosis\tO\nof\tO\nthe\tO\npain\tB-Disease\n.\tO\n\nNine\tO\npatients\tO\nwith\tO\nsevere\tO\npain\tB-Disease\nin\tO\ntheir\tO\nfeet\tO\n,\tO\nwhich\tO\nwas\tO\nregistered\tO\nafter\tO\ntransplantation\tO\n,\tO\nwere\tO\ninvestigated\tO\n.\tO\n\nBone\tO\nscans\tO\nshowed\tO\nan\tO\nincreased\tO\ntracer\tO\nuptake\tO\nof\tO\nthe\tO\nfoot\tO\nbones\tO\n.\tO\n\nMagnetic\tO\nresonance\tO\nimaging\tO\ndemonstrated\tO\nbone\tB-Disease\nmarrow\tI-Disease\noedema\tI-Disease\nin\tO\nthe\tO\npainful\tO\nbones\tO\n.\tO\n\nPain\tB-Disease\nwas\tO\nnot\tO\nexplained\tO\nby\tO\nother\tO\ndiseases\tO\ncausing\tO\nfoot\tO\npain\tB-Disease\n,\tO\nlike\tO\nreflex\tB-Disease\nsympathetic\tI-Disease\ndystrophy\tI-Disease\n,\tO\npolyneuropathy\tB-Disease\n,\tO\nMorton\tB-Disease\n'\tI-Disease\ns\tI-Disease\nneuralgia\tI-Disease\n,\tO\ngout\tB-Disease\n,\tO\nosteoporosis\tB-Disease\n,\tO\navascular\tB-Disease\nnecrosis\tI-Disease\n,\tO\nintermittent\tB-Disease\nclaudication\tI-Disease\n,\tO\northopaedic\tO\nfoot\tB-Disease\ndeformities\tI-Disease\n,\tO\nstress\tB-Disease\nfractures\tI-Disease\n,\tO\nand\tO\nhyperparathyroidism\tB-Disease\n.\tO\n\nThe\tO\nreduction\tO\nof\tO\ncyclosporine\tB-Chemical\n-\tO\nor\tO\ntacrolimus\tB-Chemical\ntrough\tO\nlevels\tO\nand\tO\nthe\tO\nadministration\tO\nof\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\nled\tO\nto\tO\nrelief\tO\nof\tO\npain\tB-Disease\n.\tO\n\nThe\tO\nCalcineurin\tO\n-\tO\ninhibitor\tO\nInduced\tO\nPain\tB-Disease\nSyndrome\tO\n(\tO\nCIPS\tB-Disease\n)\tO\nis\tO\na\tO\nrare\tO\nbut\tO\nsevere\tO\nside\tO\neffect\tO\nof\tO\ncyclosporine\tB-Chemical\nor\tO\ntacrolimus\tB-Chemical\nand\tO\nis\tO\naccurately\tO\ndiagnosed\tO\nby\tO\nits\tO\ntypical\tO\npresentation\tO\n,\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nbone\tO\nscans\tO\n.\tO\n\nIncorrect\tO\ndiagnosis\tO\nof\tO\nthe\tO\nsyndrome\tO\nwill\tO\nlead\tO\nto\tO\na\tO\nsignificant\tO\nreduction\tO\nof\tO\nlife\tO\nquality\tO\nin\tO\npatients\tO\nsuffering\tO\nfrom\tO\nCIPS\tB-Disease\n.\tO\n\nBrain\tO\nnatriuretic\tO\npeptide\tO\nis\tO\na\tO\npredictor\tO\nof\tO\nanthracycline\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nAnthracyclines\tB-Chemical\nare\tO\neffective\tO\nantineoplastic\tO\ndrugs\tO\n,\tO\nbut\tO\nthey\tO\nfrequently\tO\ncause\tO\ndose\tO\n-\tO\nrelated\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nThe\tO\ncardiotoxicity\tB-Disease\nof\tO\nconventional\tO\nanthracycline\tB-Chemical\ntherapy\tO\nhighlights\tO\na\tO\nneed\tO\nto\tO\nsearch\tO\nfor\tO\nmethods\tO\nthat\tO\nare\tO\nhighly\tO\nsensitive\tO\nand\tO\ncapable\tO\nof\tO\npredicting\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nWe\tO\nmeasured\tO\nthe\tO\nplasma\tO\nlevel\tO\nof\tO\nbrain\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nBNP\tO\n)\tO\nto\tO\ndetermine\tO\nwhether\tO\nBNP\tO\nmight\tO\nserve\tO\nas\tO\na\tO\nsimple\tO\ndiagnostic\tO\nindicator\tO\nof\tO\nanthracycline\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nleukemia\tI-Disease\ntreated\tO\nwith\tO\na\tO\ndaunorubicin\tB-Chemical\n(\tO\nDNR\tB-Chemical\n)\tO\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nThirteen\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nleukemia\tI-Disease\nwere\tO\ntreated\tO\nwith\tO\na\tO\nDNR\tB-Chemical\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nCardiac\tO\nfunctions\tO\nwere\tO\nevaluated\tO\nwith\tO\nradionuclide\tO\nangiography\tO\nbefore\tO\nchemotherapies\tO\n.\tO\n\nThe\tO\nplasma\tO\nlevels\tO\nof\tO\natrial\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nANP\tO\n)\tO\nand\tO\nBNP\tO\nwere\tO\nmeasured\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\nradionuclide\tO\nangiography\tO\n.\tO\n\nThree\tO\npatients\tO\ndeveloped\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\nafter\tO\nthe\tO\ncompletion\tO\nof\tO\nchemotherapy\tO\n.\tO\n\nFive\tO\npatients\tO\nwere\tO\ndiagnosed\tO\nas\tO\nhaving\tO\nsubclinical\tO\nheart\tB-Disease\nfailure\tI-Disease\nafter\tO\nthe\tO\ncompletion\tO\nof\tO\nchemotherapy\tO\n.\tO\n\nThe\tO\nplasma\tO\nlevels\tO\nof\tO\nBNP\tO\nin\tO\nall\tO\nthe\tO\npatients\tO\nwith\tO\nclinical\tO\nand\tO\nsubclinical\tO\nheart\tB-Disease\nfailure\tI-Disease\nincreased\tO\nabove\tO\nthe\tO\nnormal\tO\nlimit\tO\n(\tO\n40\tO\npg\tO\n/\tO\nml\tO\n)\tO\nbefore\tO\nthe\tO\ndetection\tO\nof\tO\nclinical\tO\nor\tO\nsubclinical\tO\nheart\tB-Disease\nfailure\tI-Disease\nby\tO\nradionuclide\tO\nangiography\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nBNP\tO\ndid\tO\nnot\tO\nincrease\tO\nin\tO\nthe\tO\npatients\tO\nwithout\tO\nheart\tB-Disease\nfailure\tI-Disease\ngiven\tO\nDNR\tB-Chemical\n,\tO\neven\tO\nat\tO\nmore\tO\nthan\tO\n700\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n.\tO\n\nThe\tO\nplasma\tO\nlevel\tO\nof\tO\nANP\tO\ndid\tO\nnot\tO\nalways\tO\nincrease\tO\nin\tO\nall\tO\nthe\tO\npatients\tO\nwith\tO\nclinical\tO\nand\tO\nsubclinical\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nThese\tO\npreliminary\tO\nresults\tO\nsuggest\tO\nthat\tO\nBNP\tO\nmay\tO\nbe\tO\nuseful\tO\nas\tO\nan\tO\nearly\tO\nand\tO\nsensitive\tO\nindicator\tO\nof\tO\nanthracycline\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nNephrotoxicity\tB-Disease\nof\tO\ncombined\tO\ncephalothin\tB-Chemical\n-\tO\ngentamicin\tB-Chemical\nregimen\tO\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\nacute\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\n,\tO\ncharacterized\tO\nclinically\tO\nby\tO\nacute\tO\noliguric\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nwhile\tO\nthey\tO\nwere\tO\nreceiving\tO\na\tO\ncombination\tO\nof\tO\ncephalothin\tB-Chemical\nsodium\tI-Chemical\nand\tO\ngentamicin\tB-Chemical\nsulfate\tI-Chemical\ntherapy\tO\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\ngiven\tO\nthis\tO\ndrug\tO\nregimen\tO\nshould\tO\nbe\tO\nobserved\tO\nvery\tO\ncarefully\tO\nfor\tO\nearly\tO\nsigns\tO\nof\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\nthis\tO\nantibiotic\tO\ncombination\tO\nshould\tO\nbe\tO\navoided\tO\nespecially\tO\nin\tO\nelderly\tO\npatients\tO\n.\tO\n\nPatients\tO\nwith\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\nshould\tO\nnot\tO\nbe\tO\ngiven\tO\nthis\tO\nregimen\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tO\napoptotic\tO\nand\tO\nnecrotic\tB-Disease\ncell\tO\ndeaths\tO\nduring\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n,\tO\namiodarone\tB-Chemical\n-\tO\ninduced\tO\nlung\tB-Disease\ntoxicity\tI-Disease\nand\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nby\tO\na\tO\nnovel\tO\nIH636\tB-Chemical\ngrape\tI-Chemical\nseed\tI-Chemical\nproanthocyanidin\tI-Chemical\nextract\tI-Chemical\n.\tO\n\nGrape\tB-Chemical\nseed\tI-Chemical\nextract\tI-Chemical\n,\tO\nprimarily\tO\na\tO\nmixture\tO\nof\tO\nproanthocyanidins\tB-Chemical\n,\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nmodulate\tO\na\tO\nwide\tO\n-\tO\nrange\tO\nof\tO\nbiological\tO\n,\tO\npharmacological\tO\nand\tO\ntoxicological\tO\neffects\tO\nwhich\tO\nare\tO\nmainly\tO\ncytoprotective\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tO\nof\tO\nIH636\tB-Chemical\ngrape\tI-Chemical\nseed\tI-Chemical\nproanthocyanidin\tI-Chemical\nextract\tI-Chemical\n(\tO\nGSPE\tB-Chemical\n)\tO\nto\tO\nprevent\tO\nacetaminophen\tB-Chemical\n(\tO\nAAP\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n,\tO\namiodarone\tB-Chemical\n(\tO\nAMI\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nlung\tB-Disease\ntoxicity\tI-Disease\n,\tO\nand\tO\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nExperimental\tO\ndesign\tO\nconsisted\tO\nof\tO\nfour\tO\ngroups\tO\n:\tO\ncontrol\tO\n(\tO\nvehicle\tO\nalone\tO\n)\tO\n,\tO\nGSPE\tB-Chemical\nalone\tO\n,\tO\ndrug\tO\nalone\tO\nand\tO\nGSPE\tB-Chemical\n+\tO\ndrug\tO\n.\tO\n\nFor\tO\nthe\tO\ncytoprotection\tO\nstudy\tO\n,\tO\nanimals\tO\nwere\tO\norally\tO\ngavaged\tO\n100\tO\nmg\tO\n/\tO\nKg\tO\nGSPE\tB-Chemical\nfor\tO\n7\tO\n-\tO\n10\tO\ndays\tO\nfollowed\tO\nby\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\nof\tO\norgan\tO\nspecific\tO\nthree\tO\ndrugs\tO\n(\tO\nAAP\tB-Chemical\n:\tO\n500\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n24\tO\nh\tO\n;\tO\nAMI\tB-Chemical\n:\tO\n50\tO\nmg\tO\n/\tO\nKg\tO\n/\tO\nday\tO\nfor\tO\nfour\tO\ndays\tO\n;\tO\nDOX\tB-Chemical\n:\tO\n20\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n48\tO\nh\tO\n)\tO\n.\tO\n\nParameters\tO\nof\tO\nstudy\tO\nincluded\tO\nanalysis\tO\nof\tO\nserum\tO\nchemistry\tO\n(\tO\nALT\tO\n,\tO\nBUN\tO\nand\tO\nCPK\tO\n)\tO\n,\tO\nand\tO\norderly\tO\nfragmentation\tO\nof\tO\ngenomic\tO\nDNA\tO\n(\tO\nboth\tO\nendonuclease\tO\n-\tO\ndependent\tO\nand\tO\nindependent\tO\n)\tO\nin\tO\naddition\tO\nto\tO\nmicroscopic\tO\nevaluation\tO\nof\tO\ndamage\tO\nand\tO\n/\tO\nor\tO\nprotection\tO\nin\tO\ncorresponding\tO\nPAS\tO\nstained\tO\ntissues\tO\n.\tO\n\nResults\tO\nindicate\tO\nthat\tO\nGSPE\tB-Chemical\npreexposure\tO\nprior\tO\nto\tO\nAAP\tB-Chemical\n,\tO\nAMI\tB-Chemical\nand\tO\nDOX\tB-Chemical\n,\tO\nprovided\tO\nnear\tO\ncomplete\tO\nprotection\tO\nin\tO\nterms\tO\nof\tO\nserum\tO\nchemistry\tO\nchanges\tO\n(\tO\nALT\tO\n,\tO\nBUN\tO\nand\tO\nCPK\tO\n)\tO\n,\tO\nand\tO\nsignificantly\tO\nreduced\tO\nDNA\tO\nfragmentation\tO\n.\tO\n\nHistopathological\tO\nexamination\tO\nof\tO\nkidney\tO\n,\tO\nheart\tO\nand\tO\nlung\tO\nsections\tO\nrevealed\tO\nmoderate\tO\nto\tO\nmassive\tO\ntissue\tB-Disease\ndamage\tI-Disease\nwith\tO\na\tO\nvariety\tO\nof\tO\nmorphological\tO\naberrations\tO\nby\tO\nall\tO\nthe\tO\nthree\tO\ndrugs\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nGSPE\tB-Chemical\npreexposure\tO\nthan\tO\nin\tO\nits\tO\npresence\tO\n.\tO\n\nGSPE\tB-Chemical\n+\tO\ndrug\tO\nexposed\tO\ntissues\tO\nexhibited\tO\nminor\tO\nresidual\tO\ndamage\tO\nor\tO\nnear\tO\ntotal\tO\nrecovery\tO\n.\tO\n\nAdditionally\tO\n,\tO\nhistopathological\tO\nalterations\tO\nmirrored\tO\nboth\tO\nserum\tO\nchemistry\tO\nchanges\tO\nand\tO\nthe\tO\npattern\tO\nof\tO\nDNA\tO\nfragmentation\tO\n.\tO\n\nInterestingly\tO\n,\tO\nall\tO\nthe\tO\ndrugs\tO\n,\tO\nsuch\tO\nas\tO\n,\tO\nAAP\tB-Chemical\n,\tO\nAMI\tB-Chemical\nand\tO\nDOX\tB-Chemical\ninduced\tO\napoptotic\tO\ndeath\tO\nin\tO\naddition\tO\nto\tO\nnecrosis\tB-Disease\nin\tO\nthe\tO\nrespective\tO\norgans\tO\nwhich\tO\nwas\tO\nvery\tO\neffectively\tO\nblocked\tO\nby\tO\nGSPE\tB-Chemical\n.\tO\n\nSince\tO\nAAP\tB-Chemical\n,\tO\nAMI\tB-Chemical\nand\tO\nDOX\tB-Chemical\nundergo\tO\nbiotransformation\tO\nand\tO\nare\tO\nknown\tO\nto\tO\nproduce\tO\ndamaging\tO\nradicals\tO\nin\tO\nvivo\tO\n,\tO\nthe\tO\nprotection\tO\nby\tO\nGSPE\tB-Chemical\nmay\tO\nbe\tO\nlinked\tO\nto\tO\nboth\tO\ninhibition\tO\nof\tO\nmetabolism\tO\nand\tO\n/\tO\nor\tO\ndetoxification\tO\nof\tO\ncytotoxic\tO\nradicals\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nits\tO\n'\tO\npresumed\tO\ncontribution\tO\nto\tO\nDNA\tO\nrepair\tO\nmay\tO\nbe\tO\nanother\tO\nimportant\tO\nattribute\tO\n,\tO\nwhich\tO\nplayed\tO\na\tO\nrole\tO\nin\tO\nthe\tO\nchemoprevention\tO\nprocess\tO\n.\tO\n\nAdditionally\tO\n,\tO\nthis\tO\nmay\tO\nhave\tO\nbeen\tO\nthe\tO\nfirst\tO\nreport\tO\non\tO\nAMI\tB-Chemical\n-\tO\ninduced\tO\napoptotic\tO\ndeath\tO\nin\tO\nthe\tO\nlung\tO\ntissue\tO\n.\tO\n\nTaken\tO\ntogether\tO\n,\tO\nthese\tO\nevents\tO\nundoubtedly\tO\nestablish\tO\nGSPE\tB-Chemical\n'\tO\ns\tO\nabundant\tO\nbioavailability\tO\n,\tO\nand\tO\nthe\tO\npower\tO\nto\tO\ndefend\tO\nmultiple\tO\ntarget\tO\norgans\tO\nfrom\tO\ntoxic\tO\nassaults\tO\ninduced\tO\nby\tO\nstructurally\tO\ndiverse\tO\nand\tO\nfunctionally\tO\ndifferent\tO\nentities\tO\nin\tO\nvivo\tO\n.\tO\n\nAntidepressant\tB-Chemical\n-\tO\ninduced\tO\nmania\tB-Disease\nin\tO\nbipolar\tB-Disease\npatients\tO\n:\tO\nidentification\tO\nof\tO\nrisk\tO\nfactors\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nConcerns\tO\nabout\tO\npossible\tO\nrisks\tO\nof\tO\nswitching\tO\nto\tO\nmania\tB-Disease\nassociated\tO\nwith\tO\nantidepressants\tB-Chemical\ncontinue\tO\nto\tO\ninterfere\tO\nwith\tO\nthe\tO\nestablishment\tO\nof\tO\nan\tO\noptimal\tO\ntreatment\tO\nparadigm\tO\nfor\tO\nbipolar\tB-Disease\ndepression\tI-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nThe\tO\nresponse\tO\nof\tO\n44\tO\npatients\tO\nmeeting\tO\nDSM\tO\n-\tO\nIV\tO\ncriteria\tO\nfor\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\nto\tO\nnaturalistic\tO\ntreatment\tO\nwas\tO\nassessed\tO\nfor\tO\nat\tO\nleast\tO\n6\tO\nweeks\tO\nusing\tO\nthe\tO\nMontgomery\tO\n-\tO\nAsberg\tO\nDepression\tO\nRating\tO\nScale\tO\nand\tO\nthe\tO\nBech\tO\n-\tO\nRafaelson\tO\nMania\tO\nRating\tO\nScale\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tO\na\tO\nmanic\tB-Disease\nor\tO\nhypomanic\tB-Disease\nswitch\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tB-Disease\n-\tI-Disease\nIV\tI-Disease\nbipolar\tI-Disease\nI\tI-Disease\nvs\tO\n.\tO\nbipolar\tB-Disease\nII\tI-Disease\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tB-Disease\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tB-Chemical\ntherapy\tO\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tB-Chemical\ndrugs\tO\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tI-Chemical\ninhibitors\tI-Chemical\n[\tO\nSSRIs\tB-Chemical\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tB-Chemical\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tO\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSwitches\tO\nto\tO\nhypomania\tB-Disease\nor\tO\nmania\tB-Disease\noccurred\tO\nin\tO\n27\tO\n%\tO\nof\tO\nall\tO\npatients\tO\n(\tO\nN\tO\n=\tO\n12\tO\n)\tO\n(\tO\nand\tO\nin\tO\n24\tO\n%\tO\nof\tO\nthe\tO\nsubgroup\tO\nof\tO\npatients\tO\ntreated\tO\nwith\tO\nSSRIs\tB-Chemical\n[\tO\n8\tO\n/\tO\n33\tO\n]\tO\n)\tO\n;\tO\n16\tO\n%\tO\n(\tO\nN\tO\n=\tO\n7\tO\n)\tO\nexperienced\tO\nmanic\tB-Disease\nepisodes\tO\n,\tO\nand\tO\n11\tO\n%\tO\n(\tO\nN\tO\n=\tO\n5\tO\n)\tO\nexperienced\tO\nhypomanic\tB-Disease\nepisodes\tO\n.\tO\n\nSex\tO\n,\tO\nage\tO\n,\tO\ndiagnosis\tO\n(\tO\nbipolar\tB-Disease\nI\tI-Disease\nvs\tO\n.\tO\nbipolar\tB-Disease\nII\tI-Disease\n)\tO\n,\tO\nand\tO\nadditional\tO\ntreatment\tO\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nrisk\tO\nof\tO\nswitching\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nmood\tO\nswitches\tO\nseemed\tO\nnot\tO\nto\tO\ndiffer\tO\nbetween\tO\npatients\tO\nreceiving\tO\nan\tO\nanticonvulsant\tO\nand\tO\nthose\tO\nreceiving\tO\nno\tO\nmood\tO\nstabilizer\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nmood\tO\nswitches\tO\nwere\tO\nless\tO\nfrequent\tO\nin\tO\npatients\tO\nreceiving\tO\nlithium\tB-Chemical\n(\tO\n15\tO\n%\tO\n,\tO\n4\tO\n/\tO\n26\tO\n)\tO\nthan\tO\nin\tO\npatients\tO\nnot\tO\ntreated\tO\nwith\tO\nlithium\tB-Chemical\n(\tO\n44\tO\n%\tO\n,\tO\n8\tO\n/\tO\n18\tO\n;\tO\np\tO\n=\tO\n.\tO\n04\tO\n)\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tB-Disease\nepisodes\tO\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nprobability\tO\nof\tO\nswitching\tO\n,\tO\nwhereas\tO\na\tO\nhigh\tO\nscore\tO\non\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemistructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\ngreater\tO\nrisk\tO\nof\tO\nswitching\tO\n(\tO\np\tO\n=\tO\n.\tO\n008\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nfrequency\tO\nof\tO\nmood\tO\nswitching\tO\nassociated\tO\nwith\tO\nacute\tO\nantidepressant\tB-Chemical\ntherapy\tO\nmay\tO\nbe\tO\nreduced\tO\nby\tO\nlithium\tB-Chemical\ntreatment\tO\n.\tO\n\nParticular\tO\nattention\tO\nshould\tO\nbe\tO\npaid\tO\nto\tO\npatients\tO\nwith\tO\na\tO\nhyperthymic\tO\ntemperament\tO\n,\tO\nwho\tO\nhave\tO\na\tO\ngreater\tO\nrisk\tO\nof\tO\nmood\tO\nswitches\tO\n.\tO\n\nPeritubular\tO\ncapillary\tO\nbasement\tO\nmembrane\tO\nreduplication\tO\nin\tO\nallografts\tO\nand\tO\nnative\tO\nkidney\tB-Disease\ndisease\tI-Disease\n:\tO\na\tO\nclinicopathologic\tO\nstudy\tO\nof\tO\n278\tO\nconsecutive\tO\nrenal\tO\nspecimens\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAn\tO\nassociation\tO\nhas\tO\nbeen\tO\nfound\tO\nbetween\tO\ntransplant\tB-Disease\nglomerulopathy\tI-Disease\n(\tO\nTG\tB-Disease\n)\tO\nand\tO\nreduplication\tO\nof\tO\nperitubular\tO\ncapillary\tO\nbasement\tO\nmembranes\tO\n(\tO\nPTCR\tO\n)\tO\n.\tO\n\nAlthough\tO\nsuch\tO\nan\tO\nassociation\tO\nis\tO\nof\tO\npractical\tO\nand\tO\ntheoretical\tO\nimportance\tO\n,\tO\nonly\tO\none\tO\nprospective\tO\nstudy\tO\nhas\tO\ntried\tO\nto\tO\nconfirm\tO\nit\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nexamined\tO\n278\tO\nconsecutive\tO\nrenal\tO\nspecimens\tO\n(\tO\nfrom\tO\n135\tO\ntransplants\tO\nand\tO\n143\tO\nnative\tO\nkidneys\tO\n)\tO\nfor\tO\nultrastructural\tO\nevidence\tO\nof\tO\nPTCR\tO\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nrenal\tO\nallografts\tO\nwith\tO\nTG\tB-Disease\n,\tO\nwe\tO\nalso\tO\nexamined\tO\ngrafts\tO\nwith\tO\nacute\tO\nrejection\tO\n,\tO\nrecurrent\tO\nglomerulonephritis\tB-Disease\n,\tO\nchronic\tB-Disease\nallograft\tI-Disease\nnephropathy\tI-Disease\nand\tO\nstable\tO\ngrafts\tO\n(\tO\n\"\tO\nprotocol\tO\nbiopsies\tO\n\"\tO\n)\tO\n.\tO\n\nNative\tO\nkidney\tO\nspecimens\tO\nincluded\tO\na\tO\nwide\tO\nrange\tO\nof\tO\nglomerulopathies\tB-Disease\nas\tO\nwell\tO\nas\tO\ncases\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n,\tO\nmalignant\tB-Disease\nhypertension\tI-Disease\n,\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\n,\tO\nand\tO\nacute\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nfound\tO\nPTCR\tO\nin\tO\n14\tO\nof\tO\n15\tO\ncases\tO\nof\tO\nTG\tB-Disease\n,\tO\nin\tO\n7\tO\ntransplant\tO\nbiopsy\tO\nspecimens\tO\nwithout\tO\nTG\tB-Disease\n,\tO\nand\tO\nin\tO\n13\tO\nof\tO\n143\tO\nnative\tO\nkidney\tO\nbiopsy\tO\nspecimens\tO\n.\tO\n\nThese\tO\n13\tO\nincluded\tO\ncases\tO\nof\tO\nmalignant\tB-Disease\nhypertension\tI-Disease\n,\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n,\tO\nlupus\tB-Disease\nnephritis\tI-Disease\n,\tO\nHenoch\tB-Disease\n-\tI-Disease\nSchonlein\tI-Disease\nnephritis\tI-Disease\n,\tO\ncrescentic\tO\nglomerulonephritis\tB-Disease\n,\tO\nand\tO\ncocaine\tB-Chemical\n-\tO\nrelated\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nMild\tO\nPTCR\tO\nin\tO\nallografts\tO\nwithout\tO\nTG\tB-Disease\ndid\tO\nnot\tO\npredict\tO\nrenal\tB-Disease\nfailure\tI-Disease\nor\tO\nsignificant\tO\nproteinuria\tB-Disease\nafter\tO\nfollow\tO\n-\tO\nup\tO\nperiods\tO\nof\tO\nbetween\tO\n3\tO\nmonths\tO\nand\tO\n1\tO\nyear\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nconclude\tO\nthat\tO\nin\tO\ntransplants\tO\n,\tO\nthere\tO\nis\tO\na\tO\nstrong\tO\nassociation\tO\nbetween\tO\nwell\tO\n-\tO\ndeveloped\tO\nPTCR\tO\nand\tO\nTG\tB-Disease\n,\tO\nwhile\tO\nthe\tO\nsignificance\tO\nof\tO\nmild\tO\nPTCR\tO\nand\tO\nits\tO\npredictive\tO\nvalue\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nTG\tB-Disease\nis\tO\nunclear\tO\n.\tO\n\nPTCR\tO\nalso\tO\noccurs\tO\nin\tO\ncertain\tO\nnative\tO\nkidney\tB-Disease\ndiseases\tI-Disease\n,\tO\nthough\tO\nthe\tO\nassociation\tO\nis\tO\nnot\tO\nas\tO\nstrong\tO\nas\tO\nthat\tO\nfor\tO\nTG\tB-Disease\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\nrepeated\tO\nendothelial\tB-Disease\ninjury\tI-Disease\n,\tO\nincluding\tO\nimmunologic\tB-Disease\ninjury\tI-Disease\n,\tO\nmay\tO\nbe\tO\nthe\tO\ncause\tO\nof\tO\nthis\tO\nlesion\tO\nboth\tO\nin\tO\nallografts\tO\nand\tO\nnative\tO\nkidneys\tO\n.\tO\n\nCaffeine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\narrhythmia\tI-Disease\n:\tO\nan\tO\nunrecognised\tO\ndanger\tO\nof\tO\nhealthfood\tO\nproducts\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\npre\tO\n-\tO\nexisting\tO\nmitral\tB-Disease\nvalve\tI-Disease\nprolapse\tI-Disease\nwho\tO\ndeveloped\tO\nintractable\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nafter\tO\nconsuming\tO\na\tO\n\"\tO\nnatural\tO\nenergy\tO\n\"\tO\nguarana\tO\nhealth\tO\ndrink\tO\ncontaining\tO\na\tO\nhigh\tO\nconcentration\tO\nof\tO\ncaffeine\tB-Chemical\n.\tO\n\nThis\tO\ncase\tO\nhighlights\tO\nthe\tO\nneed\tO\nfor\tO\nadequate\tO\nlabelling\tO\nand\tO\nregulation\tO\nof\tO\nsuch\tO\nproducts\tO\n.\tO\n\nConformationally\tO\nrestricted\tO\nanalogs\tO\nof\tO\nBD1008\tB-Chemical\nand\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tB-Chemical\ntargeting\tO\nsigma1\tO\nreceptors\tO\nproduce\tO\nanti\tO\n-\tO\ncocaine\tB-Chemical\neffects\tO\nin\tO\nmice\tO\n.\tO\n\nCocaine\tB-Chemical\n'\tO\ns\tO\nability\tO\nto\tO\ninteract\tO\nwith\tO\nsigma\tO\nreceptors\tO\nsuggests\tO\nthat\tO\nthese\tO\nproteins\tO\nmediate\tO\nsome\tO\nof\tO\nits\tO\nbehavioral\tO\neffects\tO\n.\tO\n\nTherefore\tO\n,\tO\nthree\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nligands\tO\nwith\tO\nantagonist\tO\nactivity\tO\nwere\tO\nevaluated\tO\nin\tO\nSwiss\tO\nWebster\tO\nmice\tO\n:\tO\nBD1018\tB-Chemical\n(\tO\n3S\tB-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichlorophenyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndiazabicyclo\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n.\tI-Chemical\n3\tI-Chemical\n.\tI-Chemical\n0\tI-Chemical\n]\tI-Chemical\nnonane\tI-Chemical\n)\tO\n,\tO\nBD1063\tB-Chemical\n(\tO\n1\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichlorophenyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethylpiperazine\tI-Chemical\n)\tO\n,\tO\nand\tO\nLR132\tB-Chemical\n(\tO\n1R\tO\n,\tO\n2S\tO\n-\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncis\tO\n-\tO\nN\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n2\tO\n-\tO\n(\tO\n1\tO\n-\tO\npyrrolidinyl\tO\n)\tO\ncyclohexylamine\tO\n)\tO\n.\tO\n\nCompetition\tO\nbinding\tO\nassays\tO\ndemonstrated\tO\nthat\tO\nall\tO\nthree\tO\ncompounds\tO\nhave\tO\nhigh\tO\naffinities\tO\nfor\tO\nsigma1\tO\nreceptors\tO\n.\tO\n\nThe\tO\nthree\tO\ncompounds\tO\nvary\tO\nin\tO\ntheir\tO\naffinities\tO\nfor\tO\nsigma2\tO\nreceptors\tO\nand\tO\nexhibit\tO\nnegligible\tO\naffinities\tO\nfor\tO\ndopamine\tB-Chemical\n,\tO\nopioid\tO\n,\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nand\tO\nNMDA\tB-Chemical\nreceptors\tO\n.\tO\n\nIn\tO\nbehavioral\tO\nstudies\tO\n,\tO\npre\tO\n-\tO\ntreatment\tO\nof\tO\nmice\tO\nwith\tO\nBD1018\tB-Chemical\n,\tO\nBD1063\tB-Chemical\n,\tO\nor\tO\nLR132\tB-Chemical\nsignificantly\tO\nattenuated\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nand\tO\nlethality\tO\n.\tO\n\nMoreover\tO\n,\tO\npost\tO\n-\tO\ntreatment\tO\nwith\tO\nLR132\tB-Chemical\nprevented\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nlethality\tO\nin\tO\na\tO\nsignificant\tO\nproportion\tO\nof\tO\nanimals\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\nthe\tO\nprotection\tO\nprovided\tO\nby\tO\nthe\tO\nputative\tO\nantagonists\tO\n,\tO\nthe\tO\nwell\tO\n-\tO\ncharacterized\tO\nsigma\tO\nreceptor\tO\nagonist\tO\ndi\tB-Chemical\n-\tI-Chemical\no\tI-Chemical\n-\tI-Chemical\ntolylguanidine\tI-Chemical\n(\tO\nDTG\tB-Chemical\n)\tO\nand\tO\nthe\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nagonist\tO\nBD1031\tB-Chemical\n(\tO\n3R\tB-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichlorophenyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndiazabicyclo\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n.\tI-Chemical\n3\tI-Chemical\n.\tI-Chemical\n0\tI-Chemical\n]\tI-Chemical\nnonane\tI-Chemical\n)\tO\neach\tO\nworsened\tO\nthe\tO\nbehavioral\tO\ntoxicity\tB-Disease\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nAt\tO\ndoses\tO\nwhere\tO\nalone\tO\n,\tO\nthey\tO\nproduced\tO\nno\tO\nsignificant\tO\neffects\tO\non\tO\nlocomotion\tO\n,\tO\nBD1018\tB-Chemical\n,\tO\nBD1063\tB-Chemical\nand\tO\nLR132\tB-Chemical\nsignificantly\tO\nattenuated\tO\nthe\tO\nlocomotor\tO\nstimulatory\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nTo\tO\nfurther\tO\nvalidate\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\nanti\tO\n-\tO\ncocaine\tB-Chemical\neffects\tO\nof\tO\nthe\tO\nnovel\tO\nligands\tO\ninvolved\tO\nantagonism\tO\nof\tO\nsigma\tO\nreceptors\tO\n,\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tB-Chemical\nagainst\tO\nsigma1\tO\nreceptors\tO\nwas\tO\nalso\tO\nshown\tO\nto\tO\nsignificantly\tO\nattenuate\tO\nthe\tO\nconvulsive\tB-Disease\nand\tO\nlocomotor\tO\nstimulatory\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nTogether\tO\n,\tO\nthe\tO\ndata\tO\nsuggests\tO\nthat\tO\nfunctional\tO\nantagonism\tO\nof\tO\nsigma\tO\nreceptors\tO\nis\tO\ncapable\tO\nof\tO\nattenuating\tO\na\tO\nnumber\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nbehaviors\tO\n.\tO\n\nRanitidine\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nin\tO\na\tO\ncadaveric\tO\nrenal\tO\nallograft\tO\n.\tO\n\nRanitidine\tB-Chemical\nfrequently\tO\nis\tO\nused\tO\nfor\tO\npreventing\tO\npeptic\tO\nulceration\tO\nafter\tO\nrenal\tO\ntransplantation\tO\n.\tO\n\nThis\tO\ndrug\tO\noccasionally\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nin\tO\nnative\tO\nkidneys\tO\n.\tO\n\nThere\tO\nare\tO\nno\tO\nsimilar\tO\nreports\tO\nwith\tO\nrenal\tO\ntransplantation\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nranitidine\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nin\tO\na\tO\nrecipient\tO\nof\tO\na\tO\ncadaveric\tO\nrenal\tO\nallograft\tO\npresenting\tO\nwith\tO\nacute\tO\nallograft\tO\ndysfunction\tO\nwithin\tO\n48\tO\nhours\tO\nof\tO\nexposure\tO\nto\tO\nthe\tO\ndrug\tO\n.\tO\n\nThe\tO\nbiopsy\tO\nspecimen\tO\nshowed\tO\npathognomonic\tO\nfeatures\tO\n,\tO\nincluding\tO\neosinophilic\tO\ninfiltration\tO\nof\tO\nthe\tO\ninterstitial\tO\ncompartment\tO\n.\tO\n\nAllograft\tO\nfunction\tO\nimproved\tO\nrapidly\tO\nand\tO\nreturned\tO\nto\tO\nbaseline\tO\nafter\tO\nstopping\tO\nthe\tO\ndrug\tO\n.\tO\n\nLiver\tB-Disease\ndisease\tI-Disease\ncaused\tO\nby\tO\npropylthiouracil\tB-Chemical\n.\tO\n\nThis\tO\nreport\tO\npresents\tO\nthe\tO\nclinical\tO\n,\tO\nlaboratory\tO\n,\tO\nand\tO\nlight\tO\nand\tO\nelectron\tO\nmicroscopic\tO\nobservations\tO\non\tO\na\tO\npatient\tO\nwith\tO\nchronic\tB-Disease\nactive\tI-Disease\n(\tI-Disease\naggressive\tI-Disease\n)\tI-Disease\nhepatitis\tI-Disease\ncaused\tO\nby\tO\nthe\tO\nadministration\tO\nof\tO\npropylthiouracil\tB-Chemical\n.\tO\n\nThis\tO\nis\tO\nan\tO\naddition\tO\nto\tO\nthe\tO\nlist\tO\nof\tO\ndrugs\tO\nthat\tO\nmust\tO\nbe\tO\nconsidered\tO\nin\tO\nthe\tO\nevaluation\tO\nof\tO\nchronic\tO\nliver\tB-Disease\ndisease\tI-Disease\n.\tO\n\nWithdrawal\tB-Disease\n-\tI-Disease\nemergent\tI-Disease\nrabbit\tI-Disease\nsyndrome\tI-Disease\nduring\tO\ndose\tO\nreduction\tO\nof\tO\nrisperidone\tB-Chemical\n.\tO\n\nRabbit\tB-Disease\nsyndrome\tI-Disease\n(\tO\nRS\tB-Disease\n)\tO\nis\tO\na\tO\nrare\tO\nextrapyramidal\tO\nside\tO\neffect\tO\ncaused\tO\nby\tO\nprolonged\tO\nneuroleptic\tO\nmedication\tO\n.\tO\n\nHere\tO\nwe\tO\npresent\tO\na\tO\ncase\tO\nof\tO\nwithdrawal\tB-Disease\n-\tI-Disease\nemergent\tI-Disease\nRS\tI-Disease\n,\tO\nwhich\tO\nis\tO\nthe\tO\nfirst\tO\nof\tO\nits\tO\nkind\tO\nto\tO\nbe\tO\nreported\tO\n.\tO\n\nThe\tO\npatient\tO\ndeveloped\tO\nRS\tB-Disease\nduring\tO\ndose\tO\nreduction\tO\nof\tO\nrisperidone\tB-Chemical\n.\tO\n\nThe\tO\nsymptom\tO\nwas\tO\ntreated\tO\nsuccessfully\tO\nwith\tO\ntrihexyphenidyl\tB-Chemical\nanticholinergic\tO\ntherapy\tO\n.\tO\n\nThe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nwithdrawal\tB-Disease\n-\tI-Disease\nemergent\tI-Disease\nRS\tI-Disease\nin\tO\nthe\tO\npresent\tO\ncase\tO\nmay\tO\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nthe\tO\npharmacological\tO\nprofile\tO\nof\tO\nrisperidone\tB-Chemical\n,\tO\na\tO\nserotonin\tB-Chemical\n-\tO\ndopamine\tB-Chemical\nantagonist\tO\n,\tO\nsuggesting\tO\nthe\tO\npathophysiologic\tO\ninfluence\tO\nof\tO\nthe\tO\nserotonin\tB-Chemical\nsystem\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nRS\tB-Disease\n.\tO\n\nPharmacokinetic\tO\n/\tO\npharmacodynamic\tO\nassessment\tO\nof\tO\nthe\tO\neffects\tO\nof\tO\nE4031\tB-Chemical\n,\tO\ncisapride\tB-Chemical\n,\tO\nterfenadine\tB-Chemical\nand\tO\nterodiline\tB-Chemical\non\tO\nmonophasic\tO\naction\tO\npotential\tO\nduration\tO\nin\tO\ndog\tO\n.\tO\n\n1\tO\n.\tO\n\nTorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\nTDP\tB-Disease\n)\tO\nis\tO\na\tO\npotentially\tO\nfatal\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nassociated\tO\nwith\tO\nincreases\tO\nin\tO\nQT\tO\ninterval\tO\nand\tO\nmonophasic\tO\naction\tO\npotential\tO\nduration\tO\n(\tO\nMAPD\tO\n)\tO\n.\tO\n\nTDP\tB-Disease\nis\tO\na\tO\nside\tO\n-\tO\neffect\tO\nthat\tO\nhas\tO\nled\tO\nto\tO\nwithdrawal\tO\nof\tO\nseveral\tO\ndrugs\tO\nfrom\tO\nthe\tO\nmarket\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\nterfenadine\tB-Chemical\nand\tO\nterodiline\tB-Chemical\n)\tO\n.\tO\n\n2\tO\n.\tO\n\nThe\tO\npotential\tO\nof\tO\ncompounds\tO\nto\tO\ncause\tO\nTDP\tB-Disease\nwas\tO\nevaluated\tO\nby\tO\nmonitoring\tO\ntheir\tO\neffects\tO\non\tO\nMAPD\tO\nin\tO\ndog\tO\n.\tO\n\nFour\tO\ncompounds\tO\nknown\tO\nto\tO\nincrease\tO\nQT\tO\ninterval\tO\nand\tO\ncause\tO\nTDP\tB-Disease\nwere\tO\ninvestigated\tO\n:\tO\nterfenadine\tB-Chemical\n,\tO\nterodiline\tB-Chemical\n,\tO\ncisapride\tB-Chemical\nand\tO\nE4031\tB-Chemical\n.\tO\n\nOn\tO\nthe\tO\nbasis\tO\nthat\tO\nonly\tO\nfree\tO\ndrug\tO\nin\tO\nthe\tO\nsystemic\tO\ncirculation\tO\nwill\tO\nelicit\tO\na\tO\npharmacological\tO\nresponse\tO\ntarget\tO\n,\tO\nfree\tO\nconcentrations\tO\nin\tO\nplasma\tO\nwere\tO\nselected\tO\nto\tO\nmimic\tO\nthe\tO\nfree\tO\ndrug\tO\nexposures\tO\nin\tO\nman\tO\n.\tO\n\nInfusion\tO\nregimens\tO\nwere\tO\ndesigned\tO\nthat\tO\nrapidly\tO\nachieved\tO\nand\tO\nmaintained\tO\ntarget\tO\n-\tO\nfree\tO\nconcentrations\tO\nof\tO\nthese\tO\ndrugs\tO\nin\tO\nplasma\tO\nand\tO\ndata\tO\non\tO\nthe\tO\nrelationship\tO\nbetween\tO\nfree\tO\nconcentration\tO\nand\tO\nchanges\tO\nin\tO\nMAPD\tO\nwere\tO\nobtained\tO\nfor\tO\nthese\tO\ncompounds\tO\n.\tO\n\n3\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nthe\tO\nfree\tO\nED50\tO\nin\tO\nplasma\tO\nfor\tO\nterfenadine\tB-Chemical\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\n,\tO\nterodiline\tB-Chemical\n(\tO\n76\tO\nnM\tO\n)\tO\n,\tO\ncisapride\tB-Chemical\n(\tO\n11\tO\nnM\tO\n)\tO\nand\tO\nE4031\tB-Chemical\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\nclosely\tO\ncorrelate\tO\nwith\tO\nthe\tO\nfree\tO\nconcentration\tO\nin\tO\nman\tO\ncausing\tO\nQT\tO\neffects\tO\n.\tO\n\nFor\tO\ncompounds\tO\nthat\tO\nhave\tO\nshown\tO\nTDP\tB-Disease\nin\tO\nthe\tO\nclinic\tO\n(\tO\nterfenadine\tB-Chemical\n,\tO\nterodiline\tB-Chemical\n,\tO\ncisapride\tB-Chemical\n)\tO\nthere\tO\nis\tO\nlittle\tO\ndifferentiation\tO\nbetween\tO\nthe\tO\ndog\tO\nED50\tO\nand\tO\nthe\tO\nefficacious\tO\nfree\tO\nplasma\tO\nconcentrations\tO\nin\tO\nman\tO\n(\tO\n<\tO\n10\tO\n-\tO\nfold\tO\n)\tO\nreflecting\tO\ntheir\tO\nlimited\tO\nsafety\tO\nmargins\tO\n.\tO\n\nThese\tO\ndata\tO\nunderline\tO\nthe\tO\nneed\tO\nto\tO\nmaximize\tO\nthe\tO\ntherapeutic\tO\nratio\tO\nwith\tO\nrespect\tO\nto\tO\nTDP\tB-Disease\nin\tO\npotential\tO\ndevelopment\tO\ncandidates\tO\nand\tO\nthe\tO\nimportance\tO\nof\tO\nusing\tO\nfree\tO\ndrug\tO\nconcentrations\tO\nin\tO\npharmacokinetic\tO\n/\tO\npharmacodynamic\tO\nstudies\tO\n.\tO\n\nBladder\tO\nretention\tB-Disease\nof\tI-Disease\nurine\tI-Disease\nas\tO\na\tO\nresult\tO\nof\tO\ncontinuous\tO\nintravenous\tO\ninfusion\tO\nof\tO\nfentanyl\tB-Chemical\n:\tO\n2\tO\ncase\tO\nreports\tO\n.\tO\n\nSedation\tO\nhas\tO\nbeen\tO\ncommonly\tO\nused\tO\nin\tO\nthe\tO\nneonate\tO\nto\tO\ndecrease\tO\nthe\tO\nstress\tO\nand\tO\npain\tB-Disease\nfrom\tO\nthe\tO\nnoxious\tO\nstimuli\tO\nand\tO\ninvasive\tO\nprocedures\tO\nin\tO\nthe\tO\nneonatal\tO\nintensive\tO\ncare\tO\nunit\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nto\tO\nfacilitate\tO\nsynchrony\tO\nbetween\tO\nventilator\tO\nand\tO\nspontaneous\tO\nbreaths\tO\n.\tO\n\nFentanyl\tB-Chemical\n,\tO\nan\tO\nopioid\tO\nanalgesic\tO\n,\tO\nis\tO\nfrequently\tO\nused\tO\nin\tO\nthe\tO\nneonatal\tO\nintensive\tO\ncare\tO\nunit\tO\nsetting\tO\nfor\tO\nthese\tO\nvery\tO\npurposes\tO\n.\tO\n\nVarious\tO\nreported\tO\nside\tO\neffects\tO\nof\tO\nfentanyl\tB-Chemical\nadministration\tO\ninclude\tO\nchest\tB-Disease\nwall\tI-Disease\nrigidity\tI-Disease\n,\tO\nhypotension\tB-Disease\n,\tO\nrespiratory\tB-Disease\ndepression\tI-Disease\n,\tO\nand\tO\nbradycardia\tB-Disease\n.\tO\n\nHere\tO\n,\tO\n2\tO\ncases\tO\nof\tO\nurinary\tB-Disease\nbladder\tI-Disease\nretention\tI-Disease\nleading\tO\nto\tO\nrenal\tO\npelvocalyceal\tO\ndilatation\tO\nmimicking\tO\nhydronephrosis\tB-Disease\nas\tO\na\tO\nresult\tO\nof\tO\ncontinuous\tO\ninfusion\tO\nof\tO\nfentanyl\tB-Chemical\nare\tO\nreported\tO\n.\tO\n\nFatal\tO\nmyeloencephalopathy\tB-Disease\ndue\tO\nto\tO\naccidental\tO\nintrathecal\tO\nvincristin\tB-Chemical\nadministration\tO\n:\tO\na\tO\nreport\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nWe\tO\nreport\tO\non\tO\ntwo\tO\nfatal\tO\ncases\tO\nof\tO\naccidental\tO\nintrathecal\tO\nvincristine\tB-Chemical\ninstillation\tO\nin\tO\na\tO\n5\tO\n-\tO\nyear\tO\nold\tO\ngirl\tO\nwith\tO\nrecurrent\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleucemia\tI-Disease\nand\tO\na\tO\n57\tO\n-\tO\nyear\tO\nold\tO\nman\tO\nwith\tO\nlymphoblastic\tB-Disease\nlymphoma\tI-Disease\n.\tO\n\nThe\tO\ngirl\tO\ndied\tO\nseven\tO\ndays\tO\n,\tO\nthe\tO\nman\tO\nfour\tO\nweeks\tO\nafter\tO\nintrathecal\tO\ninjection\tO\nof\tO\nvincristine\tB-Chemical\n.\tO\n\nClinically\tO\n,\tO\nthe\tO\nonset\tO\nwas\tO\ncharacterized\tO\nby\tO\nthe\tO\nsigns\tO\nof\tO\nopistothonus\tB-Disease\n,\tI-Disease\nsensory\tI-Disease\nand\tI-Disease\nmotor\tI-Disease\ndysfunction\tI-Disease\nand\tO\nascending\tO\nparalysis\tB-Disease\n.\tO\n\nHistological\tO\nand\tO\nimmunohistochemical\tO\ninvestigations\tO\n(\tO\nHE\tO\n-\tO\nLFB\tO\n,\tO\nCD\tO\n-\tO\n68\tO\n,\tO\nNeurofilament\tO\n)\tO\nrevealed\tO\ndegeneration\tB-Disease\nof\tI-Disease\nmyelin\tI-Disease\nand\tI-Disease\naxons\tI-Disease\nas\tO\nwell\tO\nas\tO\npseudocystic\tB-Disease\ntransformation\tI-Disease\nin\tO\nareas\tO\nexposed\tO\nto\tO\nvincristine\tB-Chemical\n,\tO\naccompanied\tO\nby\tO\nsecondary\tO\nchanges\tO\nwith\tO\nnumerous\tO\nprominent\tO\nmacrophages\tO\n.\tO\n\nThe\tO\nclinical\tO\ncourse\tO\nand\tO\nhistopathological\tO\nresults\tO\nof\tO\nthe\tO\ntwo\tO\ncases\tO\nare\tO\npresented\tO\n.\tO\n\nA\tO\nreview\tO\nof\tO\nall\tO\nreported\tO\ncases\tO\nin\tO\nthe\tO\nliterature\tO\nis\tO\ngiven\tO\n.\tO\n\nA\tO\nbetter\tO\ncontrolled\tO\nregimen\tO\nfor\tO\nadministering\tO\nvincristine\tB-Chemical\nand\tO\nintrathecal\tO\nchemotherapy\tO\nis\tO\nrecommended\tO\n.\tO\n\nPalpebral\tB-Disease\ntwitching\tI-Disease\nin\tO\na\tO\ndepressed\tB-Disease\nadolescent\tO\non\tO\ncitalopram\tB-Chemical\n.\tO\n\nCurrent\tO\nestimates\tO\nsuggest\tO\nthat\tO\nbetween\tO\n0\tO\n.\tO\n4\tO\n%\tO\nand\tO\n8\tO\n.\tO\n3\tO\n%\tO\nof\tO\nchildren\tO\nand\tO\nadolescents\tO\nare\tO\naffected\tO\nby\tO\nmajor\tB-Disease\ndepression\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\nfavorable\tO\nresponse\tO\nto\tO\ntreatment\tO\nwith\tO\ncitalopram\tB-Chemical\nby\tO\na\tO\n15\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwith\tO\nmajor\tB-Disease\ndepression\tI-Disease\nwho\tO\nexhibited\tO\npalpebral\tB-Disease\ntwitching\tI-Disease\nduring\tO\nhis\tO\nfirst\tO\n2\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nThis\tO\nmay\tO\nhave\tO\nbeen\tO\na\tO\nside\tO\neffect\tO\nof\tO\ncitalopram\tB-Chemical\nas\tO\nit\tO\nremitted\tO\nwith\tO\nredistribution\tO\nof\tO\ndoses\tO\n.\tO\n\nThe\tO\n3\tO\n-\tO\nweek\tO\nsulphasalazine\tB-Chemical\nsyndrome\tO\nstrikes\tO\nagain\tO\n.\tO\n\nA\tO\n34\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nlady\tO\ndeveloped\tO\na\tO\nconstellation\tO\nof\tO\ndermatitis\tB-Disease\n,\tO\nfever\tB-Disease\n,\tO\nlymphadenopathy\tB-Disease\nand\tO\nhepatitis\tB-Disease\n,\tO\nbeginning\tO\non\tO\nthe\tO\n17th\tO\nday\tO\nof\tO\na\tO\ncourse\tO\nof\tO\noral\tO\nsulphasalazine\tB-Chemical\nfor\tO\nsero\tO\n-\tO\nnegative\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nCervical\tO\nand\tO\ninguinal\tO\nlymph\tO\nnode\tO\nbiopsies\tO\nshowed\tO\nthe\tO\nfeatures\tO\nof\tO\nsevere\tO\nnecrotising\tO\nlymphadenitis\tB-Disease\n,\tO\nassociated\tO\nwith\tO\nerythrophagocytosis\tO\nand\tO\nprominent\tO\neosinophilic\tO\ninfiltrates\tO\n,\tO\nwithout\tO\nviral\tO\ninclusion\tO\nbodies\tO\n,\tO\nsuggestive\tO\nof\tO\nan\tO\nadverse\tB-Disease\ndrug\tI-Disease\nreaction\tI-Disease\n.\tO\nA\tO\nweek\tO\nlater\tO\n,\tO\nfulminant\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nhepatitis\tI-Disease\n,\tO\nassociated\tO\nwith\tO\nthe\tO\npresence\tO\nof\tO\nanti\tO\n-\tO\nnuclear\tO\nautoantibodies\tO\n(\tO\nbut\tO\nnot\tO\nwith\tO\nother\tO\nmarkers\tO\nof\tO\nautoimmunity\tB-Disease\n)\tO\n,\tO\nand\tO\naccompanied\tO\nby\tO\nmulti\tB-Disease\n-\tI-Disease\norgan\tI-Disease\nfailure\tI-Disease\nand\tO\nsepsis\tB-Disease\n,\tO\nsupervened\tO\n.\tO\n\nShe\tO\nsubsequently\tO\ndied\tO\nsome\tO\n5\tO\nweeks\tO\nafter\tO\nthe\tO\ncommencement\tO\nof\tO\nher\tO\ndrug\tO\ntherapy\tO\n.\tO\nPost\tO\n-\tO\nmortem\tO\nexamination\tO\nshowed\tO\nevidence\tO\nof\tO\nmassive\tB-Disease\nhepatocellular\tI-Disease\nnecrosis\tI-Disease\n,\tO\nacute\tO\nhypersensitivity\tO\nmyocarditis\tB-Disease\n,\tO\nfocal\tO\nacute\tO\ntubulo\tO\n-\tO\ninterstitial\tO\nnephritis\tB-Disease\nand\tO\nextensive\tO\nbone\tB-Disease\nmarrow\tI-Disease\nnecrosis\tI-Disease\n,\tO\nwith\tO\nno\tO\nevidence\tO\nof\tO\nmalignancy\tB-Disease\n.\tO\n\nIt\tO\nis\tO\nthought\tO\nthat\tO\nthe\tO\nclinico\tO\n-\tO\npathological\tO\nfeatures\tO\nand\tO\nchronology\tO\nof\tO\nthis\tO\ncase\tO\nbore\tO\nthe\tO\nhallmarks\tO\nof\tO\nthe\tO\nso\tO\n-\tO\ncalled\tO\n\"\tO\n3\tO\n-\tO\nweek\tO\nsulphasalazine\tB-Chemical\nsyndrome\tO\n\"\tO\n,\tO\na\tO\nrare\tO\n,\tO\nbut\tO\noften\tO\nfatal\tO\n,\tO\nimmunoallergic\tO\nreaction\tO\nto\tO\nsulphasalazine\tB-Chemical\n.\tO\n\nIntravenous\tO\nadministration\tO\nof\tO\nprochlorperazine\tB-Chemical\nby\tO\n15\tO\n-\tO\nminute\tO\ninfusion\tO\nversus\tO\n2\tO\n-\tO\nminute\tO\nbolus\tO\ndoes\tO\nnot\tO\naffect\tO\nthe\tO\nincidence\tO\nof\tO\nakathisia\tB-Disease\n:\tO\na\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ncontrolled\tO\ntrial\tO\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nWe\tO\nsought\tO\nto\tO\ncompare\tO\nthe\tO\nrate\tO\nof\tO\nakathisia\tB-Disease\nafter\tO\nadministration\tO\nof\tO\nintravenous\tO\nprochlorperazine\tB-Chemical\nas\tO\na\tO\n2\tO\n-\tO\nminute\tO\nbolus\tO\nor\tO\n15\tO\n-\tO\nminute\tO\ninfusion\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nconducted\tO\na\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nof\tO\na\tO\ncentral\tO\n-\tO\ncity\tO\nteaching\tO\nhospital\tO\n.\tO\n\nPatients\tO\naged\tO\n18\tO\nyears\tO\nor\tO\nolder\tO\ntreated\tO\nwith\tO\nprochlorperazine\tB-Chemical\nfor\tO\nheadache\tB-Disease\n,\tO\nnausea\tB-Disease\n,\tO\nor\tO\nvomiting\tB-Disease\nwere\tO\neligible\tO\nfor\tO\ninclusion\tO\n.\tO\n\nStudy\tO\nparticipants\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tO\nmg\tO\nof\tO\nprochlorperazine\tB-Chemical\nadministered\tO\nintravenously\tO\nby\tO\nmeans\tO\nof\tO\n2\tO\n-\tO\nminute\tO\npush\tO\n(\tO\nbolus\tO\ngroup\tO\n)\tO\nor\tO\n10\tO\nmg\tO\ndiluted\tO\nin\tO\n50\tO\nmL\tO\nof\tO\nnormal\tO\nsaline\tO\nsolution\tO\nadministered\tO\nby\tO\nmeans\tO\nof\tO\nintravenous\tO\ninfusion\tO\nduring\tO\na\tO\n15\tO\n-\tO\nminute\tO\nperiod\tO\n(\tO\ninfusion\tO\ngroup\tO\n)\tO\n.\tO\n\nThe\tO\nmain\tO\noutcome\tO\nwas\tO\nthe\tO\nnumber\tO\nof\tO\nstudy\tO\nparticipants\tO\nexperiencing\tO\nakathisia\tB-Disease\nwithin\tO\n60\tO\nminutes\tO\nof\tO\nadministration\tO\n.\tO\n\nAkathisia\tO\nwas\tO\ndefined\tO\nas\tO\neither\tO\na\tO\nspontaneous\tO\nreport\tO\nof\tO\nrestlessness\tO\nor\tO\nagitation\tB-Disease\nor\tO\na\tO\nchange\tO\nof\tO\n2\tO\nor\tO\nmore\tO\nin\tO\nthe\tO\npatient\tO\n-\tO\nreported\tO\nakathisia\tB-Disease\nrating\tO\nscale\tO\nand\tO\na\tO\nchange\tO\nof\tO\nat\tO\nleast\tO\n1\tO\nin\tO\nthe\tO\ninvestigator\tO\n-\tO\nobserved\tO\nakathisia\tB-Disease\nrating\tO\nscale\tO\n.\tO\n\nThe\tO\nintensity\tO\nof\tO\nheadache\tB-Disease\nand\tO\nnausea\tB-Disease\nwas\tO\nmeasured\tO\nwith\tO\na\tO\n100\tO\n-\tO\nmm\tO\nvisual\tO\nanalog\tO\nscale\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOne\tO\nhundred\tO\npatients\tO\nwere\tO\nenrolled\tO\n.\tO\n\nOne\tO\nstudy\tO\nparticipant\tO\nwas\tO\nexcluded\tO\nafter\tO\nprotocol\tO\nviolation\tO\n.\tO\n\nSeventy\tO\n-\tO\nthree\tO\npercent\tO\n(\tO\n73\tO\n/\tO\n99\tO\n)\tO\nof\tO\nthe\tO\nstudy\tO\nparticipants\tO\nwere\tO\ntreated\tO\nfor\tO\nheadache\tB-Disease\nand\tO\n70\tO\n%\tO\n(\tO\n70\tO\n/\tO\n99\tO\n)\tO\nfor\tO\nnausea\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\nbolus\tO\ngroup\tO\n,\tO\n26\tO\n.\tO\n0\tO\n%\tO\n(\tO\n13\tO\n/\tO\n50\tO\n)\tO\nhad\tO\nakathisia\tB-Disease\ncompared\tO\nwith\tO\n32\tO\n.\tO\n7\tO\n%\tO\n(\tO\n16\tO\n/\tO\n49\tO\n)\tO\nin\tO\nthe\tO\ninfusion\tO\ngroup\tO\n(\tO\nDelta\tO\n=\tO\n-\tO\n6\tO\n.\tO\n7\tO\n%\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n-\tO\n24\tO\n.\tO\n6\tO\n%\tO\nto\tO\n11\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\ndifference\tO\nbetween\tO\nthe\tO\nbolus\tO\nand\tO\ninfusion\tO\ngroups\tO\nin\tO\nthe\tO\npercentage\tO\nof\tO\nparticipants\tO\nwho\tO\nsaw\tO\na\tO\n50\tO\n%\tO\nreduction\tO\nin\tO\ntheir\tO\nheadache\tB-Disease\nintensity\tO\nwithin\tO\n30\tO\nminutes\tO\nwas\tO\n11\tO\n.\tO\n8\tO\n%\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n-\tO\n9\tO\n.\tO\n6\tO\n%\tO\nto\tO\n33\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\ndifference\tO\nin\tO\nthe\tO\npercentage\tO\nof\tO\npatients\tO\nwith\tO\na\tO\n50\tO\n%\tO\nreduction\tO\nin\tO\ntheir\tO\nnausea\tB-Disease\nwas\tO\n12\tO\n.\tO\n6\tO\n%\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n-\tO\n4\tO\n.\tO\n6\tO\n%\tO\nto\tO\n29\tO\n.\tO\n8\tO\n%\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nA\tO\n50\tO\n%\tO\nreduction\tO\nin\tO\nthe\tO\nincidence\tO\nof\tO\nakathisia\tB-Disease\nwhen\tO\nprochlorperazine\tB-Chemical\nwas\tO\nadministered\tO\nby\tO\nmeans\tO\nof\tO\n15\tO\n-\tO\nminute\tO\nintravenous\tO\ninfusion\tO\nversus\tO\na\tO\n2\tO\n-\tO\nminute\tO\nintravenous\tO\npush\tO\nwas\tO\nnot\tO\ndetected\tO\n.\tO\n\nThe\tO\nefficacy\tO\nof\tO\nprochlorperazine\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nheadache\tB-Disease\nand\tO\nnausea\tB-Disease\nlikewise\tO\ndid\tO\nnot\tO\nappear\tO\nto\tO\nbe\tO\naffected\tO\nby\tO\nthe\tO\nrate\tO\nof\tO\nadministration\tO\n,\tO\nalthough\tO\nno\tO\nformal\tO\nstatistical\tO\ncomparisons\tO\nwere\tO\nmade\tO\n.\tO\n\nCombined\tO\nantiretroviral\tO\ntherapy\tO\ncauses\tO\ncardiomyopathy\tB-Disease\nand\tO\nelevates\tO\nplasma\tO\nlactate\tB-Chemical\nin\tO\ntransgenic\tO\nAIDS\tB-Disease\nmice\tO\n.\tO\n\nHighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nis\tO\nimplicated\tO\nin\tO\ncardiomyopathy\tB-Disease\n(\tO\nCM\tB-Disease\n)\tO\nand\tO\nin\tO\nelevated\tO\nplasma\tO\nlactate\tB-Chemical\n(\tO\nLA\tB-Chemical\n)\tO\nin\tO\nAIDS\tB-Disease\nthrough\tO\nmechanisms\tO\nof\tO\nmitochondrial\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nTo\tO\ndetermine\tO\nmitochondrial\tO\nevents\tO\nfrom\tO\nHAART\tO\nin\tO\nvivo\tO\n,\tO\n8\tO\n-\tO\nweek\tO\n-\tO\nold\tO\nhemizygous\tO\ntransgenic\tO\nAIDS\tB-Disease\nmice\tO\n(\tO\nNL4\tO\n-\tO\n3Delta\tO\ngag\tO\n/\tO\npol\tO\n;\tO\nTG\tO\n)\tO\nand\tO\nwild\tO\n-\tO\ntype\tO\nFVB\tO\n/\tO\nn\tO\nlittermates\tO\nwere\tO\ntreated\tO\nwith\tO\nthe\tO\nHAART\tO\ncombination\tO\nof\tO\nzidovudine\tB-Chemical\n,\tO\nlamivudine\tB-Chemical\n,\tO\nand\tO\nindinavir\tB-Chemical\nor\tO\nvehicle\tO\ncontrol\tO\nfor\tO\n10\tO\ndays\tO\nor\tO\n35\tO\ndays\tO\n.\tO\n\nAt\tO\ntermination\tO\nof\tO\nthe\tO\nexperiments\tO\n,\tO\nmice\tO\nunderwent\tO\nechocardiography\tO\n,\tO\nquantitation\tO\nof\tO\nabundance\tO\nof\tO\nmolecular\tO\nmarkers\tO\nof\tO\nCM\tB-Disease\n(\tO\nventricular\tO\nmRNA\tO\nencoding\tO\natrial\tO\nnatriuretic\tO\nfactor\tO\n[\tO\nANF\tO\n]\tO\nand\tO\nsarcoplasmic\tO\ncalcium\tB-Chemical\nATPase\tO\n[\tO\nSERCA2\tO\n]\tO\n)\tO\n,\tO\nand\tO\ndetermination\tO\nof\tO\nplasma\tO\nLA\tB-Chemical\n.\tO\n\nMyocardial\tO\nhistologic\tO\nfeatures\tO\nwere\tO\nanalyzed\tO\nsemiquantitatively\tO\nand\tO\nresults\tO\nwere\tO\nconfirmed\tO\nby\tO\ntransmission\tO\nelectron\tO\nmicroscopy\tO\n.\tO\n\nAfter\tO\n35\tO\ndays\tO\nin\tO\nthe\tO\nTG\tO\n+\tO\nHAART\tO\ncohort\tO\n,\tO\nleft\tO\nventricular\tO\nmass\tO\nincreased\tO\n160\tO\n%\tO\nby\tO\nechocardiography\tO\n.\tO\n\nMolecularly\tO\n,\tO\nANF\tO\nmRNA\tO\nincreased\tO\n250\tO\n%\tO\nand\tO\nSERCA2\tO\nmRNA\tO\ndecreased\tO\n57\tO\n%\tO\n.\tO\n\nBiochemically\tO\n,\tO\nLA\tB-Chemical\nwas\tO\nelevated\tO\n(\tO\n8\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n0\tO\nmM\tO\n)\tO\n.\tO\n\nPathologically\tO\n,\tO\ngranular\tO\ncytoplasmic\tO\nchanges\tO\nwere\tO\nfound\tO\nin\tO\ncardiac\tO\nmyocytes\tO\n,\tO\nindicating\tO\nenlarged\tO\n,\tO\ndamaged\tO\nmitochondria\tO\n.\tO\n\nFindings\tO\nwere\tO\nconfirmed\tO\nultrastructurally\tO\n.\tO\n\nNo\tO\nchanges\tO\nwere\tO\nfound\tO\nin\tO\nother\tO\ncohorts\tO\n.\tO\n\nAfter\tO\n10\tO\ndays\tO\n,\tO\nonly\tO\nANF\tO\nwas\tO\nelevated\tO\n,\tO\nand\tO\nonly\tO\nin\tO\nthe\tO\nTG\tO\n+\tO\nHAART\tO\ncohort\tO\n.\tO\n\nResults\tO\nshow\tO\nthat\tO\ncumulative\tO\nHAART\tO\ncaused\tO\nmitochondrial\tO\nCM\tB-Disease\nwith\tO\nelevated\tO\nLA\tB-Chemical\nin\tO\nAIDS\tB-Disease\ntransgenic\tO\nmice\tO\n.\tO\n\nA\tO\nPhase\tO\nII\tO\ntrial\tO\nof\tO\ncisplatin\tB-Chemical\nplus\tO\nWR\tB-Chemical\n-\tI-Chemical\n2721\tI-Chemical\n(\tO\namifostine\tB-Chemical\n)\tO\nfor\tO\nmetastatic\tO\nbreast\tB-Disease\ncarcinoma\tI-Disease\n:\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nStudy\tO\n(\tO\nE8188\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCisplatin\tB-Chemical\nhas\tO\nminimal\tO\nantitumor\tO\nactivity\tO\nwhen\tO\nused\tO\nas\tO\nsecond\tO\n-\tO\nor\tO\nthird\tO\n-\tO\nline\tO\ntreatment\tO\nof\tO\nmetastatic\tO\nbreast\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nOlder\tO\nreports\tO\nsuggest\tO\nan\tO\nobjective\tO\nresponse\tO\nrate\tO\nof\tO\n8\tO\n%\tO\nwhen\tO\n60\tO\n-\tO\n120\tO\nmg\tO\n/\tO\nm2\tO\nof\tO\ncisplatin\tB-Chemical\nis\tO\nadministered\tO\nevery\tO\n3\tO\n-\tO\n4\tO\nweeks\tO\n.\tO\n\nAlthough\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\neffect\tO\nhas\tO\nbeen\tO\nobserved\tO\nwith\tO\ncisplatin\tB-Chemical\n,\tO\nthe\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicities\tB-Disease\nassociated\tO\nwith\tO\ncisplatin\tB-Chemical\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nnephrotoxicity\tB-Disease\n,\tO\nototoxicity\tB-Disease\n,\tO\nand\tO\nneurotoxicity\tB-Disease\n)\tO\nhave\tO\nlimited\tO\nits\tO\nuse\tO\nas\tO\na\tO\ntreatment\tO\nfor\tO\nbreast\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nWR\tB-Chemical\n-\tI-Chemical\n2721\tI-Chemical\nor\tO\namifostine\tB-Chemical\ninitially\tO\nwas\tO\ndeveloped\tO\nto\tO\nprotect\tO\nmilitary\tO\npersonnel\tO\nin\tO\nthe\tO\nevent\tO\nof\tO\nnuclear\tO\nwar\tO\n.\tO\n\nAmifostine\tB-Chemical\nsubsequently\tO\nwas\tO\nshown\tO\nto\tO\nprotect\tO\nnormal\tO\ntissues\tO\nfrom\tO\nthe\tO\ntoxic\tO\neffects\tO\nof\tO\nalkylating\tB-Chemical\nagents\tI-Chemical\nand\tO\ncisplatin\tB-Chemical\nwithout\tO\ndecreasing\tO\nthe\tO\nantitumor\tO\neffect\tO\nof\tO\nthe\tO\nchemotherapy\tO\n.\tO\n\nEarly\tO\ntrials\tO\nof\tO\ncisplatin\tB-Chemical\nand\tO\namifostine\tB-Chemical\nalso\tO\nsuggested\tO\nthat\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\ncisplatin\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n,\tO\nototoxicity\tB-Disease\n,\tO\nand\tO\nneuropathy\tB-Disease\nwere\tO\nreduced\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nPhase\tO\nII\tO\nstudy\tO\nof\tO\nthe\tO\ncombination\tO\nof\tO\ncisplatin\tB-Chemical\nplus\tO\namifostine\tB-Chemical\nwas\tO\nconducted\tO\nin\tO\npatients\tO\nwith\tO\nprogressive\tO\nmetastatic\tO\nbreast\tB-Disease\ncarcinoma\tI-Disease\nwho\tO\nhad\tO\nreceived\tO\none\tO\n,\tO\nbut\tO\nnot\tO\nmore\tO\nthan\tO\none\tO\n,\tO\nchemotherapy\tO\nregimen\tO\nfor\tO\nmetastatic\tO\ndisease\tO\n.\tO\n\nPatients\tO\nreceived\tO\namifostine\tB-Chemical\n,\tO\n910\tO\nmg\tO\n/\tO\nm2\tO\nintravenously\tO\nover\tO\n15\tO\nminutes\tO\n.\tO\n\nAfter\tO\ncompletion\tO\nof\tO\nthe\tO\namifostine\tB-Chemical\ninfusion\tO\n,\tO\ncisplatin\tB-Chemical\n120\tO\nmg\tO\n/\tO\nm2\tO\nwas\tO\nadministered\tO\nover\tO\n30\tO\nminutes\tO\n.\tO\n\nIntravenous\tO\nhydration\tO\nand\tO\nmannitol\tB-Chemical\nwas\tO\nadministered\tO\nbefore\tO\nand\tO\nafter\tO\ncisplatin\tB-Chemical\n.\tO\n\nTreatment\tO\nwas\tO\nadministered\tO\nevery\tO\n3\tO\nweeks\tO\nuntil\tO\ndisease\tO\nprogression\tO\n.\tO\n\nRESULTS\tO\n:\tO\nForty\tO\n-\tO\nfour\tO\npatients\tO\nwere\tO\nenrolled\tO\nin\tO\nthe\tO\nstudy\tO\nof\tO\nwhich\tO\n7\tO\n(\tO\n16\tO\n%\tO\n)\tO\nwere\tO\nineligible\tO\n.\tO\n\nA\tO\nmedian\tO\nof\tO\n2\tO\ncycles\tO\nof\tO\ntherapy\tO\nwas\tO\nadministered\tO\nto\tO\nthe\tO\n37\tO\neligible\tO\npatients\tO\n.\tO\n\nSix\tO\npartial\tO\nresponses\tO\nwere\tO\nobserved\tO\nfor\tO\nan\tO\noverall\tO\nresponse\tO\nrate\tO\nof\tO\n16\tO\n%\tO\n.\tO\n\nMost\tO\npatients\tO\n(\tO\n57\tO\n%\tO\n)\tO\nstopped\tO\ntreatment\tO\nbecause\tO\nof\tO\ndisease\tO\nprogression\tO\n.\tO\n\nNeurologic\tB-Disease\ntoxicity\tI-Disease\nwas\tO\nreported\tO\nin\tO\n52\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nSeven\tO\ndifferent\tO\nlife\tO\n-\tO\nthreatening\tO\ntoxicities\tB-Disease\nwere\tO\nobserved\tO\nin\tO\npatients\tO\nwhile\tO\nreceiving\tO\ntreatment\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tO\nof\tO\ncisplatin\tB-Chemical\nand\tO\namifostine\tB-Chemical\nin\tO\nthis\tO\nstudy\tO\nresulted\tO\nin\tO\nan\tO\noverall\tO\nresponse\tO\nrate\tO\nof\tO\n16\tO\n%\tO\n.\tO\n\nNeither\tO\na\tO\ntumor\tB-Disease\n-\tO\nprotective\tO\neffect\tO\nnor\tO\nreduced\tO\ntoxicity\tB-Disease\nto\tO\nnormal\tO\ntissues\tO\nwas\tO\nobserved\tO\nwith\tO\nthe\tO\naddition\tO\nof\tO\namifostine\tB-Chemical\nto\tO\ncisplatin\tB-Chemical\nin\tO\nthis\tO\ntrial\tO\n.\tO\n\nOral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nAn\tO\nassociation\tO\nbetween\tO\nthe\tO\nuse\tO\nof\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nhas\tO\nbeen\tO\nfound\tO\nin\tO\nsome\tO\n,\tO\nbut\tO\nnot\tO\nall\tO\n,\tO\nstudies\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthis\tO\nassociation\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\ntype\tO\nof\tO\nprogestagen\tB-Chemical\nincluded\tO\nin\tO\nthird\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\ndesogestrel\tB-Chemical\nor\tO\ngestodene\tB-Chemical\n)\tO\nand\tO\nsecond\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nlevonorgestrel\tB-Chemical\n)\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n,\tO\nthe\tO\ndose\tO\nof\tO\nestrogen\tB-Chemical\n,\tO\nand\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nprothrombotic\tO\nmutations\tO\nMETHODS\tO\n:\tO\nIn\tO\na\tO\nnationwide\tO\n,\tO\npopulation\tO\n-\tO\nbased\tO\n,\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n,\tO\nwe\tO\nidentified\tO\nand\tO\nenrolled\tO\n248\tO\nwomen\tO\n18\tO\nthrough\tO\n49\tO\nyears\tO\nof\tO\nage\tO\nwho\tO\nhad\tO\nhad\tO\na\tO\nfirst\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nbetween\tO\n1990\tO\nand\tO\n1995\tO\nand\tO\n925\tO\ncontrol\tO\nwomen\tO\nwho\tO\nhad\tO\nnot\tO\nhad\tO\na\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nand\tO\nwho\tO\nwere\tO\nmatched\tO\nfor\tO\nage\tO\n,\tO\ncalendar\tO\nyear\tO\nof\tO\nthe\tO\nindex\tO\nevent\tO\n,\tO\nand\tO\narea\tO\nof\tO\nresidence\tO\n.\tO\n\nSubjects\tO\nsupplied\tO\ninformation\tO\non\tO\noral\tB-Chemical\n-\tI-Chemical\ncontraceptive\tI-Chemical\nuse\tO\nand\tO\nmajor\tO\ncardiovascular\tO\nrisk\tO\nfactors\tO\n.\tO\n\nAn\tO\nanalysis\tO\nfor\tO\nfactor\tO\nV\tO\nLeiden\tO\nand\tO\nthe\tO\nG20210A\tO\nmutation\tO\nin\tO\nthe\tO\nprothrombin\tO\ngene\tO\nwas\tO\nconducted\tO\nin\tO\n217\tO\npatients\tO\nand\tO\n763\tO\ncontrols\tO\nRESULTS\tO\n:\tO\nThe\tO\nodds\tO\nratio\tO\nfor\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\namong\tO\nwomen\tO\nwho\tO\nused\tO\nany\tO\ntype\tO\nof\tO\ncombined\tO\noral\tB-Chemical\ncontraceptive\tI-Chemical\n,\tO\nas\tO\ncompared\tO\nwith\tO\nnonusers\tO\n,\tO\nwas\tO\n2\tO\n.\tO\n0\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n2\tO\n.\tO\n8\tO\n)\tO\n.\tO\n\nThe\tO\nadjusted\tO\nodds\tO\nratio\tO\nwas\tO\n2\tO\n.\tO\n5\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n4\tO\n.\tO\n1\tO\n)\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\n1\tO\n.\tO\n3\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n7\tO\nto\tO\n2\tO\n.\tO\n5\tO\n)\tO\namong\tO\nthose\tO\nwho\tO\nused\tO\nthird\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nAmong\tO\nwomen\tO\nwho\tO\nused\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n,\tO\nthe\tO\nodds\tO\nratio\tO\nwas\tO\n2\tO\n.\tO\n1\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n3\tO\n.\tO\n0\tO\n)\tO\nfor\tO\nthose\tO\nwithout\tO\na\tO\nprothrombotic\tO\nmutation\tO\nand\tO\n1\tO\n.\tO\n9\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n6\tO\nto\tO\n5\tO\n.\tO\n5\tO\n)\tO\nfor\tO\nthose\tO\nwith\tO\na\tO\nmutation\tO\nCONCLUSIONS\tO\n:\tO\nThe\tO\nrisk\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nincreased\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nThe\tO\nresults\tO\nwith\tO\nrespect\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\nthird\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nwere\tO\ninconclusive\tO\nbut\tO\nsuggested\tO\nthat\tO\nthe\tO\nrisk\tO\nwas\tO\nlower\tO\nthan\tO\nthe\tO\nrisk\tO\nassociated\tO\nwith\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nsimilar\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nwhether\tO\nor\tO\nnot\tO\nthey\tO\nhad\tO\na\tO\nprothrombotic\tO\nmutation\tO\n.\tO\n\nEnd\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n(\tO\nESRD\tB-Disease\n)\tO\nafter\tO\northotopic\tO\nliver\tO\ntransplantation\tO\n(\tO\nOLTX\tO\n)\tO\nusing\tO\ncalcineurin\tO\n-\tO\nbased\tO\nimmunotherapy\tO\n:\tO\nrisk\tO\nof\tO\ndevelopment\tO\nand\tO\ntreatment\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\ncalcineurin\tO\ninhibitors\tO\ncyclosporine\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\nare\tO\nboth\tO\nknown\tO\nto\tO\nbe\tO\nnephrotoxic\tB-Disease\n.\tO\n\nTheir\tO\nuse\tO\nin\tO\northotopic\tO\nliver\tO\ntransplantation\tO\n(\tO\nOLTX\tO\n)\tO\nhas\tO\ndramatically\tO\nimproved\tO\nsuccess\tO\nrates\tO\n.\tO\n\nRecently\tO\n,\tO\nhowever\tO\n,\tO\nwe\tO\nhave\tO\nhad\tO\nan\tO\nincrease\tO\nof\tO\npatients\tO\nwho\tO\nare\tO\npresenting\tO\nafter\tO\nOLTX\tO\nwith\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n(\tO\nESRD\tB-Disease\n)\tO\n.\tO\n\nThis\tO\nretrospective\tO\nstudy\tO\nexamines\tO\nthe\tO\nincidence\tO\nand\tO\ntreatment\tO\nof\tO\nESRD\tB-Disease\nand\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n(\tO\nCRF\tB-Disease\n)\tO\nin\tO\nOLTX\tO\npatients\tO\n.\tO\n\nMETHODS\tO\n:\tO\nPatients\tO\nreceiving\tO\nan\tO\nOLTX\tO\nonly\tO\nfrom\tO\nJune\tO\n1985\tO\nthrough\tO\nDecember\tO\nof\tO\n1994\tO\nwho\tO\nsurvived\tO\n6\tO\nmonths\tO\npostoperatively\tO\nwere\tO\nstudied\tO\n(\tO\nn\tO\n=\tO\n834\tO\n)\tO\n.\tO\n\nOur\tO\nprospectively\tO\ncollected\tO\ndatabase\tO\nwas\tO\nthe\tO\nsource\tO\nof\tO\ninformation\tO\n.\tO\n\nPatients\tO\nwere\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n:\tO\nControls\tO\n,\tO\nno\tO\nCRF\tB-Disease\nor\tO\nESRD\tB-Disease\n,\tO\nn\tO\n=\tO\n748\tO\n;\tO\nCRF\tB-Disease\n,\tO\nsustained\tO\nserum\tO\ncreatinine\tB-Chemical\n>\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nn\tO\n=\tO\n41\tO\n;\tO\nand\tO\nESRD\tB-Disease\n,\tO\nn\tO\n=\tO\n45\tO\n.\tO\n\nGroups\tO\nwere\tO\ncompared\tO\nfor\tO\npreoperative\tO\nlaboratory\tO\nvariables\tO\n,\tO\ndiagnosis\tO\n,\tO\npostoperative\tO\nvariables\tO\n,\tO\nsurvival\tO\n,\tO\ntype\tO\nof\tO\nESRD\tB-Disease\ntherapy\tO\n,\tO\nand\tO\nsurvival\tO\nfrom\tO\nonset\tO\nof\tO\nESRD\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nAt\tO\n13\tO\nyears\tO\nafter\tO\nOLTX\tO\n,\tO\nthe\tO\nincidence\tO\nof\tO\nsevere\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\nwas\tO\n18\tO\n.\tO\n1\tO\n%\tO\n(\tO\nCRF\tB-Disease\n8\tO\n.\tO\n6\tO\n%\tO\nand\tO\nESRD\tB-Disease\n9\tO\n.\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nCompared\tO\nwith\tO\ncontrol\tO\npatients\tO\n,\tO\nCRF\tB-Disease\nand\tO\nESRD\tB-Disease\npatients\tO\nhad\tO\nhigher\tO\npreoperative\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\n,\tO\na\tO\ngreater\tO\npercentage\tO\nof\tO\npatients\tO\nwith\tO\nhepatorenal\tB-Disease\nsyndrome\tI-Disease\n,\tO\nhigher\tO\npercentage\tO\nrequirement\tO\nfor\tO\ndialysis\tO\nin\tO\nthe\tO\nfirst\tO\n3\tO\nmonths\tO\npostoperatively\tO\n,\tO\nand\tO\na\tO\nhigher\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tB-Chemical\n.\tO\n\nMultivariate\tO\nstepwise\tO\nlogistic\tO\nregression\tO\nanalysis\tO\nusing\tO\npreoperative\tO\nand\tO\npostoperative\tO\nvariables\tO\nidentified\tO\nthat\tO\nan\tO\nincrease\tO\nof\tO\nserum\tO\ncreatinine\tB-Chemical\ncompared\tO\nwith\tO\naverage\tO\nat\tO\n1\tO\nyear\tO\n,\tO\n3\tO\nmonths\tO\n,\tO\nand\tO\n4\tO\nweeks\tO\npostoperatively\tO\nwere\tO\nindependent\tO\nrisk\tO\nfactors\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nCRF\tB-Disease\nor\tO\nESRD\tB-Disease\nwith\tO\nodds\tO\nratios\tO\nof\tO\n2\tO\n.\tO\n6\tO\n,\tO\n2\tO\n.\tO\n2\tO\n,\tO\nand\tO\n1\tO\n.\tO\n6\tO\n,\tO\nrespectively\tO\n.\tO\n\nOverall\tO\nsurvival\tO\nfrom\tO\nthe\tO\ntime\tO\nof\tO\nOLTX\tO\nwas\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\namong\tO\ngroups\tO\n,\tO\nbut\tO\nby\tO\nyear\tO\n13\tO\n,\tO\nthe\tO\nsurvival\tO\nof\tO\nthe\tO\npatients\tO\nwho\tO\nhad\tO\nESRD\tB-Disease\nwas\tO\nonly\tO\n28\tO\n.\tO\n2\tO\n%\tO\ncompared\tO\nwith\tO\n54\tO\n.\tO\n6\tO\n%\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nPatients\tO\ndeveloping\tO\nESRD\tB-Disease\nhad\tO\na\tO\n6\tO\n-\tO\nyear\tO\nsurvival\tO\nafter\tO\nonset\tO\nof\tO\nESRD\tB-Disease\nof\tO\n27\tO\n%\tO\nfor\tO\nthe\tO\npatients\tO\nreceiving\tO\nhemodialysis\tO\nversus\tO\n71\tO\n.\tO\n4\tO\n%\tO\nfor\tO\nthe\tO\npatients\tO\ndeveloping\tO\nESRD\tB-Disease\nwho\tO\nsubsequently\tO\nreceived\tO\nkidney\tO\ntransplants\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPatients\tO\nwho\tO\nare\tO\nmore\tO\nthan\tO\n10\tO\nyears\tO\npost\tO\n-\tO\nOLTX\tO\nhave\tO\nCRF\tB-Disease\nand\tO\nESRD\tB-Disease\nat\tO\na\tO\nhigh\tO\nrate\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nESRD\tB-Disease\ndecreases\tO\nsurvival\tO\n,\tO\nparticularly\tO\nin\tO\nthose\tO\npatients\tO\ntreated\tO\nwith\tO\ndialysis\tO\nonly\tO\n.\tO\n\nPatients\tO\nwho\tO\ndevelop\tO\nESRD\tB-Disease\nhave\tO\na\tO\nhigher\tO\npreoperative\tO\nand\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tB-Chemical\nand\tO\nare\tO\nmore\tO\nlikely\tO\nto\tO\nhave\tO\nhepatorenal\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nan\tO\nincrease\tO\nof\tO\nserum\tO\ncreatinine\tB-Chemical\nat\tO\nvarious\tO\ntimes\tO\npostoperatively\tO\nis\tO\nmore\tO\npredictive\tO\nof\tO\nthe\tO\ndevelopment\tO\nof\tO\nCRF\tB-Disease\nor\tO\nESRD\tB-Disease\n.\tO\n\nNew\tO\nstrategies\tO\nfor\tO\nlong\tO\n-\tO\nterm\tO\nimmunosuppression\tO\nmay\tO\nbe\tO\nneeded\tO\nto\tO\ndecrease\tO\nthis\tO\ncomplication\tO\n.\tO\n\nEpileptic\tB-Disease\nseizures\tI-Disease\nfollowing\tO\ncortical\tO\napplication\tO\nof\tO\nfibrin\tO\nsealants\tO\ncontaining\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\nin\tO\nrats\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nFibrin\tO\nsealants\tO\n(\tO\nFS\tO\n)\tO\nderived\tO\nfrom\tO\nhuman\tO\nplasma\tO\nare\tO\nfrequently\tO\nused\tO\nin\tO\nneurosurgery\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\nincrease\tO\nclot\tO\nstability\tO\n,\tO\nFS\tO\ntypically\tO\ncontain\tO\naprotinin\tO\n,\tO\na\tO\nnatural\tO\nfibrinolysis\tO\ninhibitor\tO\n.\tO\n\nRecently\tO\n,\tO\nsynthetic\tO\nfibrinolysis\tO\ninhibitors\tO\nsuch\tO\nas\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\n(\tO\ntAMCA\tB-Chemical\n)\tO\nhave\tO\nbeen\tO\nconsidered\tO\nas\tO\nsubstitutes\tO\nfor\tO\naprotinin\tO\n.\tO\n\nHowever\tO\n,\tO\ntAMCA\tB-Chemical\nhas\tO\nbeen\tO\nshown\tO\nto\tO\ncause\tO\nepileptic\tB-Disease\nseizures\tI-Disease\n.\tO\n\nWe\tO\nwanted\tO\nto\tO\nstudy\tO\nwhether\tO\ntAMCA\tB-Chemical\nretains\tO\nits\tO\nconvulsive\tB-Disease\naction\tO\nif\tO\nincorporated\tO\ninto\tO\na\tO\nFS\tO\n.\tO\n\nMETHOD\tO\n:\tO\nFS\tO\ncontaining\tO\naprotinin\tO\nor\tO\ndifferent\tO\nconcentrations\tO\nof\tO\ntAMCA\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\n-\tO\n47\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\n)\tO\nwere\tO\napplied\tO\nto\tO\nthe\tO\npial\tO\nsurface\tO\nof\tO\nthe\tO\ncortex\tO\nof\tO\nanaesthetized\tO\nrats\tO\n.\tO\n\nThe\tO\nresponse\tO\nof\tO\nthe\tO\nanimals\tO\nwas\tO\nevaluated\tO\nusing\tO\nelectroencephalography\tO\nand\tO\nby\tO\nmonitoring\tO\nthe\tO\nclinical\tO\nbehaviour\tO\nduring\tO\nand\tO\nafter\tO\nrecovery\tO\nfrom\tO\nanaesthesia\tO\n.\tO\n\nFINDINGS\tO\n:\tO\nFS\tO\ncontaining\tO\ntAMCA\tB-Chemical\ncaused\tO\nparoxysmal\tO\nbrain\tO\nactivity\tO\nwhich\tO\nwas\tO\nassociated\tO\nwith\tO\ndistinct\tO\nconvulsive\tB-Disease\nbehaviours\tO\n.\tO\n\nThe\tO\ndegree\tO\nof\tO\nthese\tO\nseizures\tB-Disease\nincreased\tO\nwith\tO\nincreasing\tO\nconcentration\tO\nof\tO\ntAMCA\tB-Chemical\n.\tO\n\nThus\tO\n,\tO\nFS\tO\ncontaining\tO\n47\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\ntAMCA\tB-Chemical\nevoked\tO\ngeneralized\tB-Disease\nseizures\tI-Disease\nin\tO\nall\tO\ntested\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nwhile\tO\nthe\tO\nlowest\tO\nconcentration\tO\nof\tO\ntAMCA\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\n)\tO\nonly\tO\nevoked\tO\nbrief\tO\nepisodes\tO\nof\tO\njerk\tO\n-\tO\ncorrelated\tO\nconvulsive\tB-Disease\npotentials\tO\nin\tO\n1\tO\nof\tO\n6\tO\nrats\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nFS\tO\ncontaining\tO\naprotinin\tO\ndid\tO\nnot\tO\nevoke\tO\nany\tO\nparoxysmal\tO\nactivity\tO\n.\tO\n\nINTERPRETATION\tO\n:\tO\nTranexamic\tB-Chemical\nacid\tI-Chemical\nretains\tO\nits\tO\nconvulsive\tB-Disease\naction\tO\nwithin\tO\nFS\tO\n.\tO\n\nThus\tO\n,\tO\nuse\tO\nof\tO\nFS\tO\ncontaining\tO\ntAMCA\tB-Chemical\nfor\tO\nsurgery\tO\nwithin\tO\nor\tO\nclose\tO\nto\tO\nthe\tO\nCNS\tO\nmay\tO\npose\tO\na\tO\nsubstantial\tO\nrisk\tO\nto\tO\nthe\tO\npatient\tO\n.\tO\n\nSequential\tO\nobservations\tO\nof\tO\nexencephaly\tB-Disease\nand\tO\nsubsequent\tO\nmorphological\tO\nchanges\tO\nby\tO\nmouse\tO\nexo\tO\nutero\tO\ndevelopment\tO\nsystem\tO\n:\tO\nanalysis\tO\nof\tO\nthe\tO\nmechanism\tO\nof\tO\ntransformation\tO\nfrom\tO\nexencephaly\tB-Disease\nto\tO\nanencephaly\tB-Disease\n.\tO\n\nAnencephaly\tB-Disease\nhas\tO\nbeen\tO\nsuggested\tO\nto\tO\ndevelop\tO\nfrom\tO\nexencephaly\tB-Disease\n;\tO\nhowever\tO\n,\tO\nthere\tO\nis\tO\nlittle\tO\ndirect\tO\nexperimental\tO\nevidence\tO\nto\tO\nsupport\tO\nthis\tO\n,\tO\nand\tO\nthe\tO\nmechanism\tO\nof\tO\ntransformation\tO\nremains\tO\nunclear\tO\n.\tO\n\nWe\tO\nexamined\tO\nthis\tO\ntheory\tO\nusing\tO\nthe\tO\nexo\tO\nutero\tO\ndevelopment\tO\nsystem\tO\nthat\tO\nallows\tO\ndirect\tO\nand\tO\nsequential\tO\nobservations\tO\nof\tO\nmid\tO\n-\tO\nto\tO\nlate\tO\n-\tO\ngestation\tO\nmouse\tO\nembryos\tO\n.\tO\n\nWe\tO\nobserved\tO\nthe\tO\nexencephaly\tB-Disease\ninduced\tO\nby\tO\n5\tB-Chemical\n-\tI-Chemical\nazacytidine\tI-Chemical\nat\tO\nembryonic\tO\nday\tO\n13\tO\n.\tO\n5\tO\n(\tO\nE13\tO\n.\tO\n5\tO\n)\tO\n,\tO\nlet\tO\nthe\tO\nembryos\tO\ndevelop\tO\nexo\tO\nutero\tO\nuntil\tO\nE18\tO\n.\tO\n5\tO\n,\tO\nand\tO\nre\tO\n-\tO\nobserved\tO\nthe\tO\nsame\tO\nembryos\tO\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nWe\tO\nconfirmed\tO\nseveral\tO\ncases\tO\nof\tO\ntransformation\tO\nfrom\tO\nexencephaly\tB-Disease\nto\tO\nanencephaly\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nin\tO\nmany\tO\ncases\tO\n,\tO\nthe\tO\nexencephalic\tB-Disease\nbrain\tO\ntissue\tO\nwas\tO\npreserved\tO\nwith\tO\nmore\tO\nor\tO\nless\tO\nreduction\tO\nduring\tO\nthis\tO\nperiod\tO\n.\tO\n\nTo\tO\nanalyze\tO\nthe\tO\ntransformation\tO\npatterns\tO\n,\tO\nwe\tO\nclassified\tO\nthe\tO\nexencephaly\tB-Disease\nby\tO\nsize\tO\nand\tO\nshape\tO\nof\tO\nthe\tO\nexencephalic\tB-Disease\ntissue\tO\ninto\tO\nseveral\tO\ntypes\tO\nat\tO\nE13\tO\n.\tO\n5\tO\nand\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nIt\tO\nwas\tO\nfound\tO\nthat\tO\nthe\tO\ntransformation\tO\nof\tO\nexencephalic\tB-Disease\ntissue\tO\nwas\tO\nnot\tO\nsimply\tO\nsize\tO\n-\tO\ndependent\tO\n,\tO\nand\tO\nall\tO\ncases\tO\nof\tO\nanencephaly\tB-Disease\nat\tO\nE18\tO\n.\tO\n5\tO\nresulted\tO\nfrom\tO\nembryos\tO\nwith\tO\na\tO\nlarge\tO\namount\tO\nof\tO\nexencephalic\tB-Disease\ntissue\tO\nat\tO\nE13\tO\n.\tO\n5\tO\n.\tO\n\nMicroscopic\tO\nobservation\tO\nshowed\tO\nthe\tO\nconfiguration\tO\nof\tO\nexencephaly\tB-Disease\nat\tO\nE13\tO\n.\tO\n5\tO\n,\tO\nfrequent\tO\nhemorrhaging\tB-Disease\nand\tO\ndetachment\tO\nof\tO\nthe\tO\nneural\tO\nplate\tO\nfrom\tO\nsurface\tO\nectoderm\tO\nin\tO\nthe\tO\nexencephalic\tB-Disease\nhead\tO\nat\tO\nE15\tO\n.\tO\n5\tO\n,\tO\nand\tO\nmultiple\tO\nmodes\tO\nof\tO\nreduction\tO\nin\tO\nthe\tO\nexencephalic\tB-Disease\ntissue\tO\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nFrom\tO\nobservations\tO\nof\tO\nthe\tO\nvasculature\tO\n,\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\nwere\tO\nidentified\tO\nin\tO\nthe\tO\nexencephalic\tB-Disease\nhead\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\novergrowth\tO\nof\tO\nthe\tO\nexencephalic\tB-Disease\nneural\tO\ntissue\tO\ncauses\tO\nthe\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\n,\tO\nsubsequent\tO\nperipheral\tO\ncirculatory\tB-Disease\nfailure\tI-Disease\nand\tO\n/\tO\nor\tO\nhemorrhaging\tB-Disease\nin\tO\nvarious\tO\nparts\tO\nof\tO\nthe\tO\nexencephalic\tB-Disease\nhead\tO\n,\tO\nleading\tO\nto\tO\nthe\tO\nmultiple\tO\nmodes\tO\nof\tO\ntissue\tO\nreduction\tO\nduring\tO\ntransformation\tO\nfrom\tO\nexencephaly\tB-Disease\nto\tO\nanencephaly\tB-Disease\n.\tO\n\n99mTc\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nfor\tO\ndetection\tO\nof\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nInfarct\tB-Disease\n-\tO\navid\tO\nradiopharmaceuticals\tO\nare\tO\nnecessary\tO\nfor\tO\nrapid\tO\nand\tO\ntimely\tO\ndiagnosis\tO\nof\tO\nacute\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nThe\tO\nanimal\tO\nmodel\tO\nused\tO\nto\tO\nproduce\tO\ninfarction\tB-Disease\nimplies\tO\nartery\tO\nligation\tO\nbut\tO\nchemical\tO\ninduction\tO\ncan\tO\nbe\tO\neasily\tO\nobtained\tO\nwith\tO\nisoproterenol\tB-Chemical\n.\tO\n\nA\tO\nnew\tO\ninfarct\tB-Disease\n-\tO\navid\tO\nradiopharmaceutical\tO\nbased\tO\non\tO\nglucaric\tB-Chemical\nacid\tI-Chemical\nwas\tO\nprepared\tO\nin\tO\nthe\tO\nhospital\tO\nradiopharmacy\tO\nof\tO\nthe\tO\nINCMNSZ\tO\n.\tO\n\n99mTc\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nwas\tO\neasy\tO\nto\tO\nprepare\tO\n,\tO\nstable\tO\nfor\tO\n96\tO\nh\tO\nand\tO\nwas\tO\nused\tO\nto\tO\nstudy\tO\nits\tO\nbiodistribution\tO\nin\tO\nrats\tO\nwith\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nHistological\tO\nstudies\tO\ndemonstrated\tO\nthat\tO\nthe\tO\nrats\tO\ndeveloped\tO\nan\tO\ninfarct\tB-Disease\n18\tO\nh\tO\nafter\tO\nisoproterenol\tB-Chemical\nadministration\tO\n.\tO\n\nThe\tO\nrat\tO\nbiodistribution\tO\nstudies\tO\nshowed\tO\na\tO\nrapid\tO\nblood\tO\nclearance\tO\nvia\tO\nthe\tO\nkidneys\tO\n.\tO\n\nThirty\tO\nminutes\tO\nafter\tO\n99mTc\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nadministration\tO\nthe\tO\nstandardised\tO\nheart\tO\nuptake\tO\nvalue\tO\nS\tO\n(\tO\nh\tO\n)\tO\nUV\tO\nwas\tO\n4\tO\n.\tO\n7\tO\nin\tO\ninfarcted\tO\nrat\tO\nheart\tO\nwhich\tO\nis\tO\nsix\tO\ntimes\tO\nmore\tO\nthan\tO\nin\tO\nnormal\tO\nrats\tO\n.\tO\n\nROIs\tO\ndrawn\tO\nover\tO\nthe\tO\ngamma\tO\ncamera\tO\nimages\tO\nshowed\tO\na\tO\nratio\tO\nof\tO\n4\tO\n.\tO\n4\tO\n.\tO\n\nThe\tO\nhigh\tO\nimage\tO\nquality\tO\nsuggests\tO\nthat\tO\nhigh\tO\ncontrast\tO\nimages\tO\ncan\tO\nbe\tO\nobtained\tO\nin\tO\nhumans\tO\nand\tO\nthe\tO\n96\tO\nh\tO\nstability\tO\nmakes\tO\nit\tO\nan\tO\nideal\tO\nagent\tO\nto\tO\ndetect\tO\n,\tO\nin\tO\npatients\tO\n,\tO\nearly\tO\ncardiac\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nBupropion\tB-Chemical\n(\tO\nZyban\tB-Chemical\n)\tO\ntoxicity\tB-Disease\n.\tO\n\nBupropion\tB-Chemical\nis\tO\na\tO\nmonocyclic\tO\nantidepressant\tB-Chemical\nstructurally\tO\nrelated\tO\nto\tO\namphetamine\tB-Chemical\n.\tO\n\nZyban\tB-Chemical\n,\tO\na\tO\nsustained\tO\n-\tO\nrelease\tO\nformulation\tO\nof\tO\nbupropion\tB-Chemical\nhydrochloride\tI-Chemical\n,\tO\nwas\tO\nrecently\tO\nreleased\tO\nin\tO\nIreland\tO\n,\tO\nas\tO\na\tO\nsmoking\tO\ncessation\tO\naid\tO\n.\tO\n\nIn\tO\nthe\tO\ninitial\tO\n6\tO\nmonths\tO\nsince\tO\nit\tO\n'\tO\ns\tO\nintroduction\tO\n,\tO\n12\tO\noverdose\tB-Disease\ncases\tO\nhave\tO\nbeen\tO\nreported\tO\nto\tO\nThe\tO\nNational\tO\nPoisons\tO\nInformation\tO\nCentre\tO\n.\tO\n\n8\tO\npatients\tO\ndeveloped\tO\nsymptoms\tO\nof\tO\ntoxicity\tB-Disease\n.\tO\n\nCommon\tO\nfeatures\tO\nincluded\tO\ntachycardia\tB-Disease\n,\tO\ndrowsiness\tO\n,\tO\nhallucinations\tB-Disease\nand\tO\nconvulsions\tB-Disease\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\nsevere\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\n,\tO\nincluding\tO\none\tO\npatient\tO\nwho\tO\nwas\tO\nresuscitated\tO\nfollowing\tO\na\tO\ncardiac\tB-Disease\narrest\tI-Disease\n.\tO\n\nAll\tO\npatients\tO\nrecovered\tO\nwithout\tO\nsequelae\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\n31\tO\nyear\tO\nold\tO\nfemale\tO\nwho\tO\nrequired\tO\nadmission\tO\nto\tO\nthe\tO\nIntensive\tO\nCare\tO\nUnit\tO\nfor\tO\nventilation\tO\nand\tO\nfull\tO\nsupportive\tO\ntherapy\tO\n,\tO\nfollowing\tO\ningestion\tO\nof\tO\n13\tO\n.\tO\n5g\tO\nbupropion\tB-Chemical\n.\tO\n\nRecurrent\tO\nseizures\tB-Disease\nwere\tO\ntreated\tO\nwith\tO\ndiazepam\tB-Chemical\nand\tO\nbroad\tO\ncomplex\tO\ntachycardia\tB-Disease\nwas\tO\nsuccessfully\tO\ntreated\tO\nwith\tO\nadenosine\tB-Chemical\n.\tO\n\nZyban\tB-Chemical\ncaused\tO\nsignificant\tO\nneurological\tB-Disease\nand\tI-Disease\ncardiovascular\tI-Disease\ntoxicity\tI-Disease\nin\tO\noverdose\tB-Disease\n.\tO\n\nThe\tO\npotential\tO\ntoxic\tO\neffects\tO\nshould\tO\nbe\tO\nconsidered\tO\nwhen\tO\nprescribing\tO\nit\tO\nas\tO\na\tO\nsmoking\tO\ncessation\tO\naid\tO\n.\tO\n\nGLEPP1\tO\nreceptor\tO\ntyrosine\tB-Chemical\nphosphatase\tO\n(\tO\nPtpro\tO\n)\tO\nin\tO\nrat\tO\nPAN\tB-Chemical\nnephrosis\tB-Disease\n.\tO\n\nA\tO\nmarker\tO\nof\tO\nacute\tO\npodocyte\tO\ninjury\tO\n.\tO\n\nGlomerular\tO\nepithelial\tO\nprotein\tO\n1\tO\n(\tO\nGLEPP1\tO\n)\tO\nis\tO\na\tO\npodocyte\tO\nreceptor\tO\nmembrane\tO\nprotein\tO\ntyrosine\tB-Chemical\nphosphatase\tO\nlocated\tO\non\tO\nthe\tO\napical\tO\ncell\tO\nmembrane\tO\nof\tO\nvisceral\tO\nglomerular\tO\nepithelial\tO\ncell\tO\nand\tO\nfoot\tO\nprocesses\tO\n.\tO\n\nThis\tO\nreceptor\tO\nplays\tO\na\tO\nrole\tO\nin\tO\nregulating\tO\nthe\tO\nstructure\tO\nand\tO\nfunction\tO\nof\tO\npodocyte\tO\nfoot\tO\nprocess\tO\n.\tO\n\nTo\tO\nbetter\tO\nunderstand\tO\nthe\tO\nutility\tO\nof\tO\nGLEPP1\tO\nas\tO\na\tO\nmarker\tO\nof\tO\nglomerular\tB-Disease\ninjury\tI-Disease\n,\tO\nthe\tO\namount\tO\nand\tO\ndistribution\tO\nof\tO\nGLEPP1\tO\nprotein\tO\nand\tO\nmRNA\tO\nwere\tO\nexamined\tO\nby\tO\nimmunohistochemistry\tO\n,\tO\nWestern\tO\nblot\tO\nand\tO\nRNase\tO\nprotection\tO\nassay\tO\nin\tO\na\tO\nmodel\tO\nof\tO\npodocyte\tO\ninjury\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nPuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nnephrosis\tB-Disease\nwas\tO\ninduced\tO\nby\tO\nsingle\tO\nintraperitoneal\tO\ninjection\tO\nof\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n,\tO\n20\tO\nmg\tO\n/\tO\n100g\tO\nBW\tO\n)\tO\n.\tO\n\nTissues\tO\nwere\tO\nanalyzed\tO\nat\tO\n0\tO\n,\tO\n5\tO\n,\tO\n7\tO\n,\tO\n11\tO\n,\tO\n21\tO\n,\tO\n45\tO\n,\tO\n80\tO\nand\tO\n126\tO\ndays\tO\nafter\tO\nPAN\tB-Chemical\ninjection\tO\nso\tO\nas\tO\nto\tO\ninclude\tO\nboth\tO\nthe\tO\nacute\tO\nphase\tO\nof\tO\nproteinuria\tB-Disease\nassociated\tO\nwith\tO\nfoot\tO\nprocess\tO\neffacement\tO\n(\tO\ndays\tO\n5\tO\n-\tO\n11\tO\n)\tO\nand\tO\nthe\tO\nchronic\tO\nphase\tO\nof\tO\nproteinuria\tB-Disease\nassociated\tO\nwith\tO\nglomerulosclerosis\tB-Disease\n(\tO\ndays\tO\n45\tO\n-\tO\n126\tO\n)\tO\n.\tO\n\nAt\tO\nday\tO\n5\tO\n,\tO\nGLEPP1\tO\nprotein\tO\nand\tO\nmRNA\tO\nwere\tO\nreduced\tO\nfrom\tO\nthe\tO\nnormal\tO\nrange\tO\n(\tO\n265\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n79\tO\n.\tO\n6\tO\nx\tO\n10\tO\n(\tO\n6\tO\n)\tO\nmoles\tO\n/\tO\nglomerulus\tO\nand\tO\n100\tO\n%\tO\n)\tO\nto\tO\n15\tO\n%\tO\nof\tO\nnormal\tO\n(\tO\n41\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n4\tO\n.\tO\n8\tO\nx\tO\n10\tO\n(\tO\n6\tO\n)\tO\nmoles\tO\n/\tO\nglomerulus\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n005\tO\n)\tO\n.\tO\n\nThis\tO\noccurred\tO\nin\tO\nassociation\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nurinary\tO\nprotein\tO\ncontent\tO\nfrom\tO\n1\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n1\tO\nto\tO\n99\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n61\tO\nmg\tO\n/\tO\nday\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\npodocalyxin\tO\ndid\tO\nnot\tO\nchange\tO\nsignificantly\tO\nat\tO\nthis\tO\ntime\tO\n.\tO\n\nBy\tO\nday\tO\n11\tO\n,\tO\nGLEPP1\tO\nprotein\tO\nand\tO\nmRNA\tO\nhad\tO\nbegun\tO\nto\tO\nreturn\tO\ntowards\tO\nbaseline\tO\n.\tO\n\nBy\tO\nday\tO\n45\tO\n-\tO\n126\tO\n,\tO\nat\tO\na\tO\ntime\tO\nwhen\tO\nglomerular\tO\nscarring\tO\nwas\tO\npresent\tO\n,\tO\nGLEPP1\tO\nwas\tO\nabsent\tO\nfrom\tO\nglomerulosclerotic\tO\nareas\tO\nalthough\tO\nthe\tO\ntotal\tO\nglomerular\tO\ncontent\tO\nof\tO\nGLEPP1\tO\nwas\tO\nnot\tO\ndifferent\tO\nfrom\tO\nnormal\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nGLEPP1\tO\nexpression\tO\n,\tO\nunlike\tO\npodocalyxin\tO\n,\tO\nreflects\tO\npodocyte\tO\ninjury\tO\ninduced\tO\nby\tO\nPAN\tB-Chemical\n.\tO\n\nGLEPP1\tO\nexpression\tO\nmay\tO\nbe\tO\na\tO\nuseful\tO\nmarker\tO\nof\tO\npodocyte\tO\ninjury\tO\n.\tO\n\nAntithymocyte\tB-Chemical\nglobulin\tI-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n-\tO\ninduced\tO\naplastic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nA\tO\npatient\tO\nwho\tO\nreceived\tO\nantithymocyte\tB-Chemical\nglobulin\tI-Chemical\ntherapy\tO\nfor\tO\naplastic\tB-Disease\nanemia\tI-Disease\ndue\tO\nto\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\ntherapy\tO\nis\tO\ndescribed\tO\n.\tO\n\nBone\tO\nmarrow\tO\nrecovery\tO\nand\tO\nperipheral\tO\nblood\tO\nrecovery\tO\nwere\tO\ncomplete\tO\n1\tO\nmonth\tO\nand\tO\n3\tO\nmonths\tO\n,\tO\nrespectively\tO\n,\tO\nafter\tO\ntreatment\tO\n,\tO\nand\tO\nblood\tO\ntransfusion\tO\nor\tO\nother\tO\ntherapies\tO\nwere\tO\nnot\tO\nnecessary\tO\nin\tO\na\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\nof\tO\nmore\tO\nthan\tO\n2\tO\nyears\tO\n.\tO\n\nUse\tO\nof\tO\nantithymocyte\tB-Chemical\nglobulin\tI-Chemical\nmay\tO\nbe\tO\nthe\tO\noptimal\tO\ntreatment\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n-\tO\ninduced\tO\naplastic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nMetamizol\tB-Chemical\npotentiates\tO\nmorphine\tB-Chemical\nantinociception\tO\nbut\tO\nnot\tO\nconstipation\tB-Disease\nafter\tO\nchronic\tO\ntreatment\tO\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\nantinociceptive\tO\nand\tO\nconstipating\tB-Disease\neffects\tO\nof\tO\nthe\tO\ncombination\tO\nof\tO\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nmorphine\tB-Chemical\nwith\tO\n177\tO\n.\tO\n8\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nmetamizol\tB-Chemical\nin\tO\nacutely\tO\nand\tO\nchronically\tO\ntreated\tO\n(\tO\nonce\tO\na\tO\nday\tO\nfor\tO\n12\tO\ndays\tO\n)\tO\nrats\tO\n.\tO\n\nOn\tO\nthe\tO\n13th\tO\nday\tO\n,\tO\nantinociceptive\tO\neffects\tO\nwere\tO\nassessed\tO\nusing\tO\na\tO\nmodel\tO\nof\tO\ninflammatory\tO\nnociception\tO\n,\tO\npain\tB-Disease\n-\tO\ninduced\tO\nfunctional\tO\nimpairment\tO\nmodel\tO\n,\tO\nand\tO\nthe\tO\ncharcoal\tB-Chemical\nmeal\tO\ntest\tO\nwas\tO\nused\tO\nto\tO\nevaluate\tO\nthe\tO\nintestinal\tO\ntransit\tO\n.\tO\n\nSimultaneous\tO\nadministration\tO\nof\tO\nmorphine\tB-Chemical\nwith\tO\nmetamizol\tB-Chemical\nresulted\tO\nin\tO\na\tO\nmarkedly\tO\nantinociceptive\tO\npotentiation\tO\nand\tO\nan\tO\nincreasing\tO\nof\tO\nthe\tO\nduration\tO\nof\tO\naction\tO\nafter\tO\na\tO\nsingle\tO\n(\tO\n298\tO\n+\tO\n/\tO\n-\tO\n7\tO\nvs\tO\n.\tO\n139\tO\n+\tO\n/\tO\n-\tO\n36\tO\nunits\tO\narea\tO\n(\tO\nua\tO\n)\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\nrepeated\tO\nadministration\tO\n(\tO\n280\tO\n+\tO\n/\tO\n-\tO\n17\tO\nvs\tO\n.\tO\n131\tO\n+\tO\n/\tO\n-\tO\n22\tO\nua\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nAntinociceptive\tO\neffect\tO\nof\tO\nmorphine\tB-Chemical\nwas\tO\nreduced\tO\nin\tO\nchronically\tO\ntreated\tO\nrats\tO\n(\tO\n39\tO\n+\tO\n/\tO\n-\tO\n10\tO\nvs\tO\n.\tO\n18\tO\n+\tO\n/\tO\n-\tO\n5\tO\nau\tO\n)\tO\nwhile\tO\nthe\tO\ncombination\tO\n-\tO\ninduced\tO\nantinociception\tO\nwas\tO\nremained\tO\nsimilar\tO\nas\tO\nan\tO\nacute\tO\ntreatment\tO\n(\tO\n298\tO\n+\tO\n/\tO\n-\tO\n7\tO\nvs\tO\n.\tO\n280\tO\n+\tO\n/\tO\n-\tO\n17\tO\nau\tO\n)\tO\n.\tO\n\nAcute\tO\nantinociceptive\tO\neffects\tO\nof\tO\nthe\tO\ncombination\tO\nwere\tO\npartially\tO\nprevented\tO\nby\tO\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nnaloxone\tB-Chemical\ns\tO\n.\tO\nc\tO\n.\tO\n\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nsuggesting\tO\nthe\tO\npartial\tO\ninvolvement\tO\nof\tO\nthe\tO\nopioidergic\tO\nsystem\tO\nin\tO\nthe\tO\nsynergism\tO\nobserved\tO\n.\tO\n\nIn\tO\nindependent\tO\ngroups\tO\n,\tO\nmorphine\tB-Chemical\ninhibited\tO\nthe\tO\nintestinal\tO\ntransit\tO\nin\tO\n48\tO\n+\tO\n/\tO\n-\tO\n4\tO\n%\tO\nand\tO\n38\tO\n+\tO\n/\tO\n-\tO\n4\tO\n%\tO\nafter\tO\nacute\tO\nand\tO\nchronic\tO\ntreatment\tO\n,\tO\nrespectively\tO\n,\tO\nsuggesting\tO\nthat\tO\ntolerance\tO\ndid\tO\nnot\tO\ndevelop\tO\nto\tO\nthe\tO\nconstipating\tB-Disease\neffects\tO\n.\tO\n\nThe\tO\ncombination\tO\ninhibited\tO\nintestinal\tO\ntransit\tO\nsimilar\tO\nto\tO\nthat\tO\nproduced\tO\nby\tO\nmorphine\tB-Chemical\nregardless\tO\nof\tO\nthe\tO\ntime\tO\nof\tO\ntreatment\tO\n,\tO\nsuggesting\tO\nthat\tO\nmetamizol\tB-Chemical\ndid\tO\nnot\tO\npotentiate\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nconstipation\tB-Disease\n.\tO\n\nThese\tO\nfindings\tO\nshow\tO\na\tO\nsignificant\tO\ninteraction\tO\nbetween\tO\nmorphine\tB-Chemical\nand\tO\nmetamizol\tB-Chemical\nin\tO\nchronically\tO\ntreated\tO\nrats\tO\n,\tO\nsuggesting\tO\nthat\tO\nthis\tO\ncombination\tO\ncould\tO\nbe\tO\nuseful\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nchronic\tB-Disease\npain\tI-Disease\n.\tO\n\nIfosfamide\tB-Chemical\nencephalopathy\tB-Disease\npresenting\tO\nwith\tO\nasterixis\tB-Disease\n.\tO\n\nCNS\tO\ntoxic\tO\neffects\tO\nof\tO\nthe\tO\nantineoplastic\tO\nagent\tO\nifosfamide\tB-Chemical\n(\tO\nIFX\tB-Chemical\n)\tO\nare\tO\nfrequent\tO\nand\tO\ninclude\tO\na\tO\nvariety\tO\nof\tO\nneurological\tO\nsymptoms\tO\nthat\tO\ncan\tO\nlimit\tO\ndrug\tO\nuse\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\n51\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\ndeveloped\tO\nsevere\tO\n,\tO\ndisabling\tO\nnegative\tO\nmyoclonus\tB-Disease\nof\tO\nthe\tO\nupper\tO\nand\tO\nlower\tO\nextremities\tO\nafter\tO\nthe\tO\ninfusion\tO\nof\tO\nifosfamide\tB-Chemical\nfor\tO\nplasmacytoma\tB-Disease\n.\tO\n\nHe\tO\nwas\tO\nawake\tO\n,\tO\nrevealed\tO\nno\tO\nchanges\tO\nof\tO\nmental\tO\nstatus\tO\nand\tO\nat\tO\nrest\tO\nthere\tO\nwere\tO\nno\tO\nfurther\tO\nmotor\tO\nsymptoms\tO\n.\tO\n\nCranial\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nextensive\tO\nlaboratory\tO\nstudies\tO\nfailed\tO\nto\tO\nreveal\tO\nstructural\tB-Disease\nlesions\tI-Disease\nof\tI-Disease\nthe\tI-Disease\nbrain\tI-Disease\nand\tO\nmetabolic\tB-Disease\nabnormalities\tI-Disease\n.\tO\n\nAn\tO\nelectroencephalogram\tO\nshowed\tO\ncontinuous\tO\n,\tO\ngeneralized\tO\nirregular\tO\nslowing\tO\nwith\tO\nadmixed\tO\nperiodic\tO\ntriphasic\tO\nwaves\tO\nindicating\tO\nsymptomatic\tO\nencephalopathy\tB-Disease\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nifosfamide\tB-Chemical\nwas\tO\ndiscontinued\tO\nand\tO\nwithin\tO\n12\tO\nh\tO\nthe\tO\nasterixis\tB-Disease\nresolved\tO\ncompletely\tO\n.\tO\n\nIn\tO\nthe\tO\npatient\tO\ndescribed\tO\n,\tO\nthe\tO\npresence\tO\nof\tO\nasterixis\tB-Disease\nduring\tO\ninfusion\tO\nof\tO\nifosfamide\tB-Chemical\n,\tO\nnormal\tO\nlaboratory\tO\nfindings\tO\nand\tO\nimaging\tO\nstudies\tO\nand\tO\nthe\tO\nresolution\tO\nof\tO\nsymptoms\tO\nfollowing\tO\nthe\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nsuggest\tO\nthat\tO\nnegative\tO\nmyoclonus\tB-Disease\nis\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nIFX\tB-Chemical\n.\tO\n\nAntagonism\tO\nbetween\tO\ninterleukin\tO\n3\tO\nand\tO\nerythropoietin\tO\nin\tO\nmice\tO\nwith\tO\nazidothymidine\tB-Chemical\n-\tO\ninduced\tO\nanemia\tB-Disease\nand\tO\nin\tO\nbone\tO\nmarrow\tO\nendothelial\tO\ncells\tO\n.\tO\n\nAzidothymidine\tB-Chemical\n(\tO\nAZT\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nin\tO\nmice\tO\ncan\tO\nbe\tO\nreversed\tO\nby\tO\nthe\tO\nadministration\tO\nof\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\n(\tO\nfusion\tO\nprotein\tO\nof\tO\ninsulin\tO\n-\tO\nlike\tO\ngrowth\tO\nfactor\tO\nII\tO\n(\tO\nIGF\tO\nII\tO\n)\tO\nand\tO\ninterleukin\tO\n3\tO\n)\tO\n.\tO\n\nAlthough\tO\ninterleukin\tO\n3\tO\n(\tO\nIL\tO\n-\tO\n3\tO\n)\tO\nand\tO\nerythropoietin\tO\n(\tO\nEPO\tO\n)\tO\nare\tO\nknown\tO\nto\tO\nact\tO\nsynergistically\tO\non\tO\nhematopoietic\tO\ncell\tO\nproliferation\tO\nin\tO\nvitro\tO\n,\tO\ninjection\tO\nof\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\nand\tO\nEPO\tO\nin\tO\nAZT\tB-Chemical\n-\tO\ntreated\tO\nmice\tO\nresulted\tO\nin\tO\na\tO\nreduction\tO\nof\tO\nred\tO\ncells\tO\nand\tO\nan\tO\nincrease\tO\nof\tO\nplasma\tO\nEPO\tO\nlevels\tO\nas\tO\ncompared\tO\nto\tO\nanimals\tO\ntreated\tO\nwith\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\nor\tO\nEPO\tO\nalone\tO\n.\tO\n\nWe\tO\ntested\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\nantagonistic\tO\neffect\tO\nof\tO\nIL\tO\n-\tO\n3\tO\nand\tO\nEPO\tO\non\tO\nerythroid\tO\ncells\tO\nmay\tO\nbe\tO\nmediated\tO\nby\tO\nendothelial\tO\ncells\tO\n.\tO\n\nBovine\tO\nliver\tO\nerythroid\tO\ncells\tO\nwere\tO\ncultured\tO\non\tO\nmonolayers\tO\nof\tO\nhuman\tO\nbone\tO\nmarrow\tO\nendothelial\tO\ncells\tO\npreviously\tO\ntreated\tO\nwith\tO\nEPO\tO\nand\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\nreduction\tO\nof\tO\nthymidine\tB-Chemical\nincorporation\tO\ninto\tO\nboth\tO\nerythroid\tO\nand\tO\nendothelial\tO\ncells\tO\nin\tO\ncultures\tO\npre\tO\n-\tO\ntreated\tO\nwith\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\nand\tO\nEPO\tO\n.\tO\n\nEndothelial\tO\ncell\tO\nculture\tO\nsupernatants\tO\nseparated\tO\nby\tO\nultrafiltration\tO\nand\tO\nultracentrifugation\tO\nfrom\tO\ncells\tO\ntreated\tO\nwith\tO\nEPO\tO\nand\tO\nIL\tO\n-\tO\n3\tO\nsignificantly\tO\nreduced\tO\nthymidine\tB-Chemical\nincorporation\tO\ninto\tO\nerythroid\tO\ncells\tO\nas\tO\ncompared\tO\nto\tO\nidentical\tO\nfractions\tO\nobtained\tO\nfrom\tO\nthe\tO\nmedia\tO\nof\tO\ncells\tO\ncultured\tO\nwith\tO\nEPO\tO\nalone\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nendothelial\tO\ncells\tO\ntreated\tO\nsimultaneously\tO\nwith\tO\nEPO\tO\nand\tO\nIL\tO\n-\tO\n3\tO\nhave\tO\na\tO\nnegative\tO\neffect\tO\non\tO\nerythroid\tO\ncell\tO\nproduction\tO\n.\tO\n\nThe\tO\nrelationship\tO\nbetween\tO\nhippocampal\tO\nacetylcholine\tB-Chemical\nrelease\tO\nand\tO\ncholinergic\tO\nconvulsant\tO\nsensitivity\tO\nin\tO\nwithdrawal\tO\nseizure\tB-Disease\n-\tO\nprone\tO\nand\tO\nwithdrawal\tO\nseizure\tB-Disease\n-\tO\nresistant\tO\nselected\tO\nmouse\tO\nlines\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nsepto\tO\n-\tO\nhippocampal\tO\ncholinergic\tO\npathway\tO\nhas\tO\nbeen\tO\nimplicated\tO\nin\tO\nepileptogenesis\tO\n,\tO\nand\tO\ngenetic\tO\nfactors\tO\ninfluence\tO\nthe\tO\nresponse\tO\nto\tO\ncholinergic\tO\nagents\tO\n,\tO\nbut\tO\nlimited\tO\ndata\tO\nare\tO\navailable\tO\non\tO\ncholinergic\tO\ninvolvement\tO\nin\tO\nalcohol\tB-Chemical\nwithdrawal\tO\nseverity\tO\n.\tO\n\nThus\tO\n,\tO\nthe\tO\nrelationship\tO\nbetween\tO\ncholinergic\tO\nactivity\tO\nand\tO\nresponsiveness\tO\nand\tO\nalcohol\tB-Chemical\nwithdrawal\tO\nwas\tO\ninvestigated\tO\nin\tO\na\tO\ngenetic\tO\nanimal\tO\nmodel\tO\nof\tO\nethanol\tB-Chemical\nwithdrawal\tO\nseverity\tO\n.\tO\n\nMETHODS\tO\n:\tO\nCholinergic\tO\nconvulsant\tO\nsensitivity\tO\nwas\tO\nexamined\tO\nin\tO\nalcohol\tB-Chemical\n-\tO\nna\tO\nve\tO\nWithdrawal\tO\nSeizure\tB-Disease\n-\tO\nProne\tO\n(\tO\nWSP\tO\n)\tO\nand\tO\n-\tO\nResistant\tO\n(\tO\nWSR\tO\n)\tO\nmice\tO\n.\tO\n\nAnimals\tO\nwere\tO\nadministered\tO\nnicotine\tB-Chemical\n,\tO\ncarbachol\tB-Chemical\n,\tO\nor\tO\nneostigmine\tB-Chemical\nvia\tO\ntimed\tO\ntail\tO\nvein\tO\ninfusion\tO\n,\tO\nand\tO\nthe\tO\nlatencies\tO\nto\tO\nonset\tO\nof\tO\ntremor\tB-Disease\nand\tO\nclonus\tO\nwere\tO\nrecorded\tO\nand\tO\nconverted\tO\nto\tO\nthreshold\tO\ndose\tO\n.\tO\n\nWe\tO\nalso\tO\nused\tO\nmicrodialysis\tO\nto\tO\nmeasure\tO\nbasal\tO\nand\tO\npotassium\tB-Chemical\n-\tO\nstimulated\tO\nacetylcholine\tB-Chemical\n(\tO\nACh\tB-Chemical\n)\tO\nrelease\tO\nin\tO\nthe\tO\nCA1\tO\nregion\tO\nof\tO\nthe\tO\nhippocampus\tO\n.\tO\n\nPotassium\tB-Chemical\nwas\tO\napplied\tO\nby\tO\nreverse\tO\ndialysis\tO\ntwice\tO\n,\tO\nseparated\tO\nby\tO\n75\tO\nmin\tO\n.\tO\n\nHippocampal\tO\nACh\tB-Chemical\nalso\tO\nwas\tO\nmeasured\tO\nduring\tO\ntesting\tO\nfor\tO\nhandling\tO\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nSensitivity\tO\nto\tO\nseveral\tO\nconvulsion\tB-Disease\nendpoints\tO\ninduced\tO\nby\tO\nnicotine\tB-Chemical\n,\tO\ncarbachol\tB-Chemical\n,\tO\nand\tO\nneostigmine\tB-Chemical\nwere\tO\nsignificantly\tO\ngreater\tO\nin\tO\nWSR\tO\nversus\tO\nWSP\tO\nmice\tO\n.\tO\n\nIn\tO\nmicrodialysis\tO\nexperiments\tO\n,\tO\nthe\tO\nlines\tO\ndid\tO\nnot\tO\ndiffer\tO\nin\tO\nbasal\tO\nrelease\tO\nof\tO\nACh\tB-Chemical\n,\tO\nand\tO\n50\tO\nmM\tO\nKCl\tB-Chemical\nincreased\tO\nACh\tB-Chemical\noutput\tO\nin\tO\nboth\tO\nlines\tO\nof\tO\nmice\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nincrease\tO\nin\tO\nrelease\tO\nof\tO\nACh\tB-Chemical\nproduced\tO\nby\tO\nthe\tO\nfirst\tO\napplication\tO\nof\tO\nKCl\tB-Chemical\nwas\tO\n2\tO\n-\tO\nfold\tO\nhigher\tO\nin\tO\nWSP\tO\nversus\tO\nWSR\tO\nmice\tO\n.\tO\n\nWhen\tO\nhippocampal\tO\nACh\tB-Chemical\nwas\tO\nmeasured\tO\nduring\tO\ntesting\tO\nfor\tO\nhandling\tO\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n,\tO\nextracellular\tO\nACh\tB-Chemical\nwas\tO\nsignificantly\tO\nelevated\tO\n(\tO\n192\tO\n%\tO\n)\tO\nin\tO\nWSP\tO\nmice\tO\n,\tO\nbut\tO\nwas\tO\nnonsignificantly\tO\nelevated\tO\n(\tO\n59\tO\n%\tO\n)\tO\nin\tO\nWSR\tO\nmice\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\ndifferences\tO\nin\tO\ncholinergic\tO\nactivity\tO\nand\tO\npostsynaptic\tO\nsensitivity\tO\nto\tO\ncholinergic\tO\nconvulsants\tB-Disease\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nethanol\tB-Chemical\nwithdrawal\tO\nseverity\tO\nand\tO\nimplicate\tO\ncholinergic\tO\nmechanisms\tO\nin\tO\nalcohol\tB-Chemical\nwithdrawal\tO\n.\tO\n\nSpecifically\tO\n,\tO\nWSP\tO\nmice\tO\nmay\tO\nhave\tO\nlower\tO\nsensitivity\tO\nto\tO\ncholinergic\tO\nconvulsants\tB-Disease\ncompared\tO\nwith\tO\nWSR\tO\nbecause\tO\nof\tO\npostsynaptic\tO\nreceptor\tO\ndesensitization\tO\nbrought\tO\non\tO\nby\tO\nhigher\tO\nactivity\tO\nof\tO\ncholinergic\tO\nneurons\tO\n.\tO\n\nCapsaicin\tB-Chemical\n-\tO\ninduced\tO\nmuscle\tB-Disease\npain\tI-Disease\nalters\tO\nthe\tO\nexcitability\tO\nof\tO\nthe\tO\nhuman\tO\njaw\tO\n-\tO\nstretch\tO\nreflex\tO\n.\tO\n\nThe\tO\npathophysiology\tO\nof\tO\npainful\tO\ntemporomandibular\tB-Disease\ndisorders\tI-Disease\nis\tO\nnot\tO\nfully\tO\nunderstood\tO\n,\tO\nbut\tO\nevidence\tO\nsuggests\tO\nthat\tO\nmuscle\tB-Disease\npain\tI-Disease\nmodulates\tO\nmotor\tO\nfunction\tO\nin\tO\ncharacteristic\tO\nways\tO\n.\tO\n\nThis\tO\nstudy\tO\ntested\tO\nthe\tO\nhypothesis\tO\nthat\tO\nactivation\tO\nof\tO\nnociceptive\tB-Disease\nmuscle\tI-Disease\nafferent\tO\nfibers\tO\nwould\tO\nbe\tO\nlinked\tO\nto\tO\nan\tO\nincreased\tO\nexcitability\tO\nof\tO\nthe\tO\nhuman\tO\njaw\tO\n-\tO\nstretch\tO\nreflex\tO\nand\tO\nwhether\tO\nthis\tO\nprocess\tO\nwould\tO\nbe\tO\nsensitive\tO\nto\tO\nlength\tO\nand\tO\nvelocity\tO\nof\tO\nthe\tO\nstretch\tO\n.\tO\n\nCapsaicin\tB-Chemical\n(\tO\n10\tO\nmicro\tO\ng\tO\n)\tO\nwas\tO\ninjected\tO\ninto\tO\nthe\tO\nmasseter\tO\nmuscle\tO\nto\tO\ninduce\tO\npain\tB-Disease\nin\tO\n11\tO\nhealthy\tO\nvolunteers\tO\n.\tO\n\nShort\tO\n-\tO\nlatency\tO\nreflex\tO\nresponses\tO\nwere\tO\nevoked\tO\nin\tO\nthe\tO\nmasseter\tO\nand\tO\ntemporalis\tO\nmuscles\tO\nby\tO\na\tO\nstretch\tO\ndevice\tO\nwith\tO\ndifferent\tO\nvelocities\tO\nand\tO\ndisplacements\tO\nbefore\tO\n,\tO\nduring\tO\n,\tO\nand\tO\nafter\tO\nthe\tO\npain\tB-Disease\n.\tO\n\nThe\tO\nnormalized\tO\nreflex\tO\namplitude\tO\nincreased\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nvelocity\tO\nat\tO\na\tO\ngiven\tO\ndisplacement\tO\n,\tO\nbut\tO\nremained\tO\nconstant\tO\nwith\tO\ndifferent\tO\ndisplacements\tO\nat\tO\na\tO\ngiven\tO\nvelocity\tO\n.\tO\n\nThe\tO\nnormalized\tO\nreflex\tO\namplitude\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nduring\tO\npain\tB-Disease\n,\tO\nbut\tO\nonly\tO\nat\tO\nfaster\tO\nstretches\tO\nin\tO\nthe\tO\npainful\tB-Disease\nmuscle\tI-Disease\n.\tO\n\nIncreased\tO\nsensitivity\tO\nof\tO\nthe\tO\nfusimotor\tO\nsystem\tO\nduring\tO\nacute\tO\nmuscle\tB-Disease\npain\tI-Disease\ncould\tO\nbe\tO\none\tO\nlikely\tO\nmechanism\tO\nto\tO\nexplain\tO\nthe\tO\nfindings\tO\n.\tO\n\nEffects\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\naccumbal\tO\nshell\tO\nor\tO\ncore\tO\non\tO\nthe\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nexamine\tO\nthe\tO\neffect\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\nsubregions\tO\nof\tO\nthe\tO\nnucleus\tO\naccumbens\tO\n(\tO\nthe\tO\nshell\tO\nand\tO\nthe\tO\ncore\tO\n)\tO\non\tO\nthe\tO\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\ninduced\tO\nby\tO\ncocaine\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\nimplanted\tO\nbilaterally\tO\nwith\tO\ncannulae\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\nor\tO\ncore\tO\n,\tO\nand\tO\nthen\tO\nwere\tO\nlocally\tO\ninjected\tO\nwith\tO\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\nan\tO\nantagonist\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptors\tO\n)\tO\nor\tO\nCP\tB-Chemical\n93129\tI-Chemical\n(\tO\nan\tO\nagonist\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptors\tO\n)\tO\n.\tO\n\nGiven\tO\nalone\tO\nto\tO\nany\tO\naccumbal\tO\nsubregion\tO\n,\tO\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\nor\tO\nCP\tB-Chemical\n93129\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\ndid\tO\nnot\tO\nchange\tO\nbasal\tO\nlocomotor\tO\nactivity\tO\n.\tO\n\nSystemic\tO\ncocaine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nlocomotor\tO\nactivity\tO\nof\tO\nrats\tO\n.\tO\n\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\n,\tO\nadministered\tO\nintra\tO\n-\tO\naccumbens\tO\nshell\tO\nprior\tO\nto\tO\ncocaine\tB-Chemical\n,\tO\ndose\tO\n-\tO\ndependently\tO\nattenuated\tO\nthe\tO\npsychostimulant\tO\n-\tO\ninduced\tO\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\n.\tO\n\nSuch\tO\nattenuation\tO\nwas\tO\nnot\tO\nfound\tO\nin\tO\nanimals\tO\nwhich\tO\nhad\tO\nbeen\tO\ninjected\tO\nwith\tO\nGR\tB-Chemical\n55562\tI-Chemical\ninto\tO\nthe\tO\naccumbens\tO\ncore\tO\n.\tO\n\nWhen\tO\ninjected\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n(\tO\nbut\tO\nnot\tO\nthe\tO\ncore\tO\n)\tO\nbefore\tO\ncocaine\tB-Chemical\n,\tO\nCP\tB-Chemical\n93129\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\nenhanced\tO\nthe\tO\nlocomotor\tO\nresponse\tO\nto\tO\ncocaine\tB-Chemical\n;\tO\nthe\tO\nmaximum\tO\neffect\tO\nbeing\tO\nobserved\tO\nafter\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\nof\tO\nthe\tO\nagonist\tO\n.\tO\n\nThe\tO\nlater\tO\nenhancement\tO\nwas\tO\nattenuated\tO\nafter\tO\nintra\tO\n-\tO\naccumbens\tO\nshell\tO\ntreatment\tO\nwith\tO\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\n1\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\n.\tO\n\nOur\tO\nfindings\tO\nindicate\tO\nthat\tO\ncocaine\tB-Chemical\ninduced\tO\nhyperlocomotion\tB-Disease\nis\tO\nmodified\tO\nby\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n,\tO\nbut\tO\nnot\tO\ncore\tO\n,\tO\nthis\tO\nmodification\tO\nconsisting\tO\nin\tO\ninhibitory\tO\nand\tO\nfacilitatory\tO\neffects\tO\nof\tO\nthe\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nantagonist\tO\n(\tO\nGR\tB-Chemical\n55562\tI-Chemical\n)\tO\nand\tO\nagonist\tO\n(\tO\nCP\tB-Chemical\n93129\tI-Chemical\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nIn\tO\nother\tO\nwords\tO\n,\tO\nthe\tO\npresent\tO\nresults\tO\nsuggest\tO\nthat\tO\nthe\tO\naccumbal\tO\nshell\tO\n5\tO\n-\tO\nHT1B\tO\nreceptors\tO\nplay\tO\na\tO\npermissive\tO\nrole\tO\nin\tO\nthe\tO\nbehavioural\tO\nresponse\tO\nto\tO\nthe\tO\npsychostimulant\tO\n.\tO\n\nCocaine\tB-Chemical\nrelated\tO\nchest\tB-Disease\npain\tI-Disease\n:\tO\nare\tO\nwe\tO\nseeing\tO\nthe\tO\ntip\tO\nof\tO\nan\tO\niceberg\tO\n?\tO\n\nThe\tO\nrecreational\tO\nuse\tO\nof\tO\ncocaine\tB-Chemical\nis\tO\non\tO\nthe\tO\nincrease\tO\n.\tO\n\nThe\tO\nemergency\tO\nnurse\tO\nought\tO\nto\tO\nbe\tO\nfamiliar\tO\nwith\tO\nsome\tO\nof\tO\nthe\tO\ncardiovascular\tO\nconsequences\tO\nof\tO\ncocaine\tB-Chemical\nuse\tO\n.\tO\n\nIn\tO\nparticular\tO\n,\tO\nthe\tO\ntendency\tO\nof\tO\ncocaine\tB-Chemical\nto\tO\nproduce\tO\nchest\tB-Disease\npain\tI-Disease\nought\tO\nto\tO\nbe\tO\nin\tO\nthe\tO\nmind\tO\nof\tO\nthe\tO\nemergency\tO\nnurse\tO\nwhen\tO\nfaced\tO\nwith\tO\na\tO\nyoung\tO\nvictim\tO\nof\tO\nchest\tB-Disease\npain\tI-Disease\nwho\tO\nis\tO\notherwise\tO\nat\tO\nlow\tO\nrisk\tO\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\nchest\tB-Disease\npain\tI-Disease\nrelated\tO\nto\tO\ncocaine\tB-Chemical\nuse\tO\nis\tO\ndiscussed\tO\nand\tO\ntreatment\tO\ndilemmas\tO\nare\tO\ndiscussed\tO\n.\tO\n\nFinally\tO\n,\tO\nmoral\tO\nissues\tO\nrelating\tO\nto\tO\nthe\tO\ntesting\tO\nof\tO\npotential\tO\ncocaine\tB-Chemical\nusers\tO\nwill\tO\nbe\tO\naddressed\tO\n.\tO\n\nCrossover\tO\ncomparison\tO\nof\tO\nefficacy\tO\nand\tO\npreference\tO\nfor\tO\nrizatriptan\tB-Chemical\n10\tO\nmg\tO\nversus\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\nin\tO\nmigraine\tB-Disease\n.\tO\n\nRizatriptan\tB-Chemical\nis\tO\na\tO\nselective\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n(\tO\n1B\tO\n/\tO\n1D\tO\n)\tO\nreceptor\tO\nagonist\tO\nwith\tO\nrapid\tO\noral\tO\nabsorption\tO\nand\tO\nearly\tO\nonset\tO\nof\tO\naction\tO\nin\tO\nthe\tO\nacute\tO\ntreatment\tO\nof\tO\nmigraine\tB-Disease\n.\tO\n\nThis\tO\nrandomized\tO\ndouble\tO\n-\tO\nblind\tO\ncrossover\tO\noutpatient\tO\nstudy\tO\nassessed\tO\nthe\tO\npreference\tO\nfor\tO\n1\tO\nrizatriptan\tB-Chemical\n10\tO\nmg\tO\ntablet\tO\nto\tO\n2\tO\nergotamine\tB-Chemical\n1\tO\nmg\tO\n/\tO\ncaffeine\tB-Chemical\n100\tO\nmg\tO\ntablets\tO\nin\tO\n439\tO\npatients\tO\ntreating\tO\na\tO\nsingle\tO\nmigraine\tB-Disease\nattack\tO\nwith\tO\neach\tO\ntherapy\tO\n.\tO\n\nOf\tO\npatients\tO\nexpressing\tO\na\tO\npreference\tO\n(\tO\n89\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nmore\tO\nthan\tO\ntwice\tO\nas\tO\nmany\tO\npreferred\tO\nrizatriptan\tB-Chemical\nto\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\n69\tO\n.\tO\n9\tO\nvs\tO\n.\tO\n30\tO\n.\tO\n1\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nFaster\tO\nrelief\tO\nof\tO\nheadache\tB-Disease\nwas\tO\nthe\tO\nmost\tO\nimportant\tO\nreason\tO\nfor\tO\npreference\tO\n,\tO\ncited\tO\nby\tO\n67\tO\n.\tO\n3\tO\n%\tO\nof\tO\npatients\tO\npreferring\tO\nrizatriptan\tB-Chemical\nand\tO\n54\tO\n.\tO\n2\tO\n%\tO\nof\tO\npatients\tO\nwho\tO\npreferred\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n.\tO\n\nThe\tO\nco\tO\n-\tO\nprimary\tO\nendpoint\tO\nof\tO\nbeing\tO\npain\tB-Disease\nfree\tO\nat\tO\n2\tO\nh\tO\nwas\tO\nalso\tO\nin\tO\nfavor\tO\nof\tO\nrizatriptan\tB-Chemical\n.\tO\n\nForty\tO\n-\tO\nnine\tO\npercent\tO\nof\tO\npatients\tO\nwere\tO\npain\tB-Disease\nfree\tO\n2\tO\nh\tO\nafter\tO\nrizatriptan\tB-Chemical\n,\tO\ncompared\tO\nwith\tO\n24\tO\n.\tO\n3\tO\n%\tO\ntreated\tO\nwith\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrizatriptan\tB-Chemical\nbeing\tO\nsuperior\tO\nwithin\tO\n1\tO\nh\tO\nof\tO\ntreatment\tO\n.\tO\n\nHeadache\tB-Disease\nrelief\tO\nat\tO\n2\tO\nh\tO\nwas\tO\n75\tO\n.\tO\n9\tO\n%\tO\nfor\tO\nrizatriptan\tB-Chemical\nand\tO\n47\tO\n.\tO\n3\tO\n%\tO\nfor\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nwith\tO\nrizatriptan\tB-Chemical\nbeing\tO\nsuperior\tO\nto\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\nwithin\tO\n30\tO\nmin\tO\nof\tO\ndosing\tO\n.\tO\n\nAlmost\tO\n36\tO\n%\tO\nof\tO\npatients\tO\ntaking\tO\nrizatriptan\tB-Chemical\nwere\tO\npain\tB-Disease\nfree\tO\nat\tO\n2\tO\nh\tO\nand\tO\nhad\tO\nno\tO\nrecurrence\tO\nor\tO\nneed\tO\nfor\tO\nadditional\tO\nmedication\tO\nwithin\tO\n24\tO\nh\tO\n,\tO\ncompared\tO\nto\tO\n20\tO\n%\tO\nof\tO\npatients\tO\non\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRizatriptan\tB-Chemical\nwas\tO\nalso\tO\nsuperior\tO\nto\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\nin\tO\nthe\tO\nproportions\tO\nof\tO\npatients\tO\nwith\tO\nno\tO\nnausea\tB-Disease\n,\tO\nvomiting\tB-Disease\n,\tO\nphonophobia\tB-Disease\nor\tO\nphotophobia\tB-Disease\nand\tO\nfor\tO\npatients\tO\nwith\tO\nnormal\tO\nfunction\tO\n2\tO\nh\tO\nafter\tO\ndrug\tO\nintake\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nMore\tO\npatients\tO\nwere\tO\n(\tO\ncompletely\tO\n,\tO\nvery\tO\nor\tO\nsomewhat\tO\n)\tO\nsatisfied\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tO\nwith\tO\nrizatriptan\tB-Chemical\n(\tO\n69\tO\n.\tO\n8\tO\n%\tO\n)\tO\nthan\tO\nat\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tO\nwith\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\n38\tO\n.\tO\n6\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRecurrence\tO\nrates\tO\nwere\tO\n31\tO\n.\tO\n4\tO\n%\tO\nwith\tO\nrizatriptan\tB-Chemical\nand\tO\n15\tO\n.\tO\n3\tO\n%\tO\nwith\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n.\tO\n\nBoth\tO\nactive\tO\ntreatments\tO\nwere\tO\nwell\tO\ntolerated\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tO\nevents\tO\n(\tO\nincidence\tO\n>\tO\nor\tO\n=\tO\n5\tO\n%\tO\nin\tO\none\tO\ngroup\tO\n)\tO\nafter\tO\nrizatriptan\tB-Chemical\nand\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n,\tO\nrespectively\tO\n,\tO\nwere\tO\ndizziness\tB-Disease\n(\tO\n6\tO\n.\tO\n7\tO\nand\tO\n5\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nnausea\tB-Disease\n(\tO\n4\tO\n.\tO\n2\tO\nand\tO\n8\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\nsomnolence\tB-Disease\n(\tO\n5\tO\n.\tO\n5\tO\nand\tO\n2\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nSevere\tO\nocular\tB-Disease\nand\tI-Disease\norbital\tI-Disease\ntoxicity\tI-Disease\nafter\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tB-Chemical\nfor\tO\nrecurrent\tO\nglioblastomas\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nGlioblastoma\tB-Disease\nis\tO\na\tO\nmalignant\tB-Disease\ntumor\tI-Disease\nthat\tO\noccurs\tO\nin\tO\nthe\tO\ncerebrum\tO\nduring\tO\nadulthood\tO\n.\tO\n\nWith\tO\ncurrent\tO\ntreatment\tO\nregimens\tO\nincluding\tO\ncombined\tO\nsurgery\tO\n,\tO\nradiation\tO\nand\tO\nchemotherapy\tO\n,\tO\nthe\tO\naverage\tO\nlife\tO\nexpectancy\tO\nof\tO\nthe\tO\npatients\tO\nis\tO\nlimited\tO\nto\tO\napproximately\tO\n1\tO\nyear\tO\n.\tO\n\nTherefore\tO\n,\tO\npatients\tO\nwith\tO\nglioblastoma\tB-Disease\nsometimes\tO\nhave\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarcinostatics\tO\nadded\tO\nto\tO\nthe\tO\ntreatment\tO\nregimen\tO\n.\tO\n\nGenerally\tO\n,\tO\ncarboplatin\tB-Chemical\nis\tO\nsaid\tO\nto\tO\nhave\tO\nmilder\tO\nside\tO\neffects\tO\nthan\tO\ncisplatin\tB-Chemical\n,\tO\nwhose\tO\nocular\tB-Disease\nand\tI-Disease\norbital\tI-Disease\ntoxicity\tI-Disease\nare\tO\nwell\tO\nknown\tO\n.\tO\n\nHowever\tO\n,\tO\nwe\tO\nexperienced\tO\na\tO\ncase\tO\nof\tO\nsevere\tO\nocular\tB-Disease\nand\tI-Disease\norbital\tI-Disease\ntoxicity\tI-Disease\nafter\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tB-Chemical\n,\tO\nwhich\tO\nis\tO\ninfrequently\tO\nreported\tO\n.\tO\n\nCASE\tO\n:\tO\nA\tO\n58\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nreceived\tO\nan\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tB-Chemical\nfor\tO\nrecurrent\tO\nglioblastomas\tB-Disease\nin\tO\nhis\tO\nleft\tO\ntemporal\tO\nlobe\tO\n.\tO\n\nHe\tO\ncomplained\tO\nof\tO\npain\tB-Disease\nand\tI-Disease\nvisual\tI-Disease\ndisturbance\tI-Disease\nin\tI-Disease\nthe\tI-Disease\nipsilateral\tI-Disease\neye\tI-Disease\n30\tO\nh\tO\nafter\tO\nthe\tO\ninjection\tO\n.\tO\n\nVarious\tO\nocular\tO\nsymptoms\tO\nand\tO\nfindings\tO\ncaused\tO\nby\tO\ncarboplatin\tB-Chemical\ntoxicity\tB-Disease\nwere\tO\nseen\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHe\tO\nwas\tO\ntreated\tO\nwith\tO\nintravenous\tO\nadministration\tO\nof\tO\ncorticosteroids\tO\nand\tO\nglycerin\tB-Chemical\nfor\tO\n6\tO\ndays\tO\nafter\tO\nthe\tO\ninjection\tO\n.\tO\n\nAlthough\tO\nthe\tO\nintraocular\tO\npressure\tO\nelevation\tO\ncaused\tO\nby\tO\nsecondary\tO\nacute\tO\nangle\tO\n-\tO\nclosure\tO\nglaucoma\tB-Disease\ndecreased\tO\nand\tO\nocular\tB-Disease\npain\tI-Disease\ndiminished\tO\n,\tO\ninexorable\tO\npapilledema\tB-Disease\nand\tO\nexudative\tO\nretinal\tB-Disease\ndetachment\tI-Disease\ncontinued\tO\nfor\tO\n3\tO\nweeks\tO\n.\tO\n\nFinally\tO\n,\tO\n6\tO\nweeks\tO\nlater\tO\n,\tO\ndiffuse\tO\nchorioretinal\tB-Disease\natrophy\tI-Disease\nwith\tO\noptic\tB-Disease\natrophy\tI-Disease\noccurred\tO\nand\tO\nthe\tO\nvision\tO\nin\tO\nhis\tO\nleft\tO\neye\tO\nwas\tO\nlost\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nWhen\tO\nperforming\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tB-Chemical\n,\tO\nwe\tO\nmust\tO\nbe\tO\naware\tO\nof\tO\nits\tO\npotentially\tO\nblinding\tO\nocular\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nIt\tO\nis\tO\nrecommended\tO\nthat\tO\nfurther\tO\nstudies\tO\nand\tO\ninvestigations\tO\nare\tO\nundertaken\tO\nin\tO\nthe\tO\neffort\tO\nto\tO\nminimize\tO\nsuch\tO\nsevere\tO\nside\tO\neffects\tO\n.\tO\n\nVisual\tB-Disease\nhallucinations\tI-Disease\nassociated\tO\nwith\tO\nzonisamide\tB-Chemical\n.\tO\n\nZonisamide\tB-Chemical\nis\tO\na\tO\nbroad\tO\n-\tO\nspectrum\tO\nantiepileptic\tO\ndrug\tO\nused\tO\nto\tO\ntreat\tO\nvarious\tO\ntypes\tO\nof\tO\nseizures\tB-Disease\n.\tO\n\nAlthough\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\nhave\tO\nnot\tO\nbeen\tO\nreported\tO\nas\tO\nan\tO\nadverse\tO\neffect\tO\nof\tO\nthis\tO\nagent\tO\n,\tO\nwe\tO\ndescribe\tO\nthree\tO\npatients\tO\nwho\tO\nexperienced\tO\ncomplex\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\nand\tO\naltered\tO\nmental\tO\nstatus\tO\nafter\tO\nzonisamide\tB-Chemical\ntreatment\tO\nwas\tO\nbegun\tO\nor\tO\nits\tO\ndosage\tO\nincreased\tO\n.\tO\n\nAll\tO\nthree\tO\nhad\tO\nbeen\tO\ndiagnosed\tO\nearlier\tO\nwith\tO\nepilepsy\tB-Disease\n,\tO\nand\tO\ntheir\tO\nelectroencephalogram\tO\n(\tO\nEEG\tO\n)\tO\nfindings\tO\nwere\tO\nabnormal\tO\n.\tO\n\nDuring\tO\nmonitoring\tO\n,\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nEEG\tO\nreadings\tO\n,\tO\nnor\tO\ndid\tO\nvideo\tO\nrecording\tO\ncapture\tO\nany\tO\nof\tO\nthe\tO\ndescribed\tO\nevents\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\npatients\tO\nhad\tO\nexperienced\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\nbefore\tO\nthis\tO\nevent\tO\n.\tO\n\nThe\tO\nonly\tO\nrecent\tO\nchange\tO\nin\tO\ntheir\tO\ntreatment\tO\nwas\tO\nthe\tO\nintroduction\tO\nor\tO\nincreased\tO\ndosage\tO\nof\tO\nzonisamide\tB-Chemical\n.\tO\n\nWith\tO\neither\tO\ndiscontinuation\tO\nor\tO\ndecreased\tO\ndosage\tO\nof\tO\nthe\tO\ndrug\tO\nthe\tO\nsymptoms\tO\ndisappeared\tO\nand\tO\ndid\tO\nnot\tO\nrecur\tO\n.\tO\n\nFurther\tO\nobservations\tO\nand\tO\nreports\tO\nwill\tO\nhelp\tO\nclarify\tO\nthis\tO\nadverse\tO\neffect\tO\n.\tO\n\nUntil\tO\nthen\tO\n,\tO\nclinicians\tO\nneed\tO\nto\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\npossible\tO\ncomplication\tO\nassociated\tO\nwith\tO\nzonisamide\tB-Chemical\n.\tO\n\nAnti\tO\n-\tO\nepileptic\tB-Disease\ndrugs\tO\n-\tO\ninduced\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizures\tI-Disease\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\nthree\tO\npatients\tO\nwith\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nepilepsy\tI-Disease\nafter\tO\nadministration\tO\nof\tO\ncarbamazepine\tB-Chemical\nand\tO\nvigabatrin\tB-Chemical\n.\tO\n\nDespite\tO\nthe\tO\nunderlying\tO\ndiseases\tO\n,\tO\nthe\tO\nprognosis\tO\nfor\tO\ndrug\tO\n-\tO\ninduced\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizure\tI-Disease\nis\tO\ngood\tO\nbecause\tO\nit\tO\nsubsides\tO\nrapidly\tO\nafter\tO\ndiscontinuing\tO\nthe\tO\nuse\tO\nof\tO\nthe\tO\noffending\tO\ndrugs\tO\n.\tO\n\nThe\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n-\tO\ntransmitted\tO\nthalamocortical\tO\ncircuitry\tO\naccounts\tO\nfor\tO\na\tO\nmajor\tO\npart\tO\nof\tO\nthe\tO\nunderlying\tO\nneurophysiology\tO\nof\tO\nthe\tO\nabsence\tB-Disease\nepilepsy\tI-Disease\n.\tO\n\nBecause\tO\ndrug\tO\n-\tO\ninduced\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizure\tI-Disease\nis\tO\nrare\tO\n,\tO\npro\tO\n-\tO\nabsence\tO\ndrugs\tO\ncan\tO\nonly\tO\nbe\tO\nconsidered\tO\na\tO\npromoting\tO\nfactor\tO\n.\tO\n\nThe\tO\nunderlying\tO\nepileptogenecity\tO\nof\tO\nthe\tO\npatients\tO\nor\tO\nthe\tO\nsynergistic\tO\neffects\tO\nof\tO\nthe\tO\naccompanying\tO\ndrugs\tO\nis\tO\nrequired\tO\nto\tO\ntrigger\tO\nthe\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizure\tI-Disease\n.\tO\n\nThe\tO\npossibility\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\naggravation\tO\nshould\tO\nbe\tO\nconsidered\tO\nwhenever\tO\nan\tO\nunexpected\tO\nincrease\tO\nin\tO\nseizure\tB-Disease\nfrequency\tO\nand\tO\n/\tO\nor\tO\nnew\tO\nseizure\tB-Disease\ntypes\tO\nappear\tO\nfollowing\tO\na\tO\nchange\tO\nin\tO\ndrug\tO\ntreatment\tO\n.\tO\n\nBy\tO\nunderstanding\tO\nthe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nabsence\tB-Disease\nepilepsy\tI-Disease\n,\tO\nwe\tO\ncan\tO\navoid\tO\nthe\tO\ninappropriate\tO\nuse\tO\nof\tO\nanticonvulsants\tO\nin\tO\nchildren\tO\nwith\tO\nepilepsy\tB-Disease\nand\tO\nprevent\tO\ndrug\tO\n-\tO\ninduced\tO\nabsence\tB-Disease\nseizures\tI-Disease\n.\tO\n\nPrenatal\tO\ndexamethasone\tB-Chemical\nprograms\tO\nhypertension\tB-Disease\nand\tO\nrenal\tB-Disease\ninjury\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nDexamethasone\tO\nis\tO\nfrequently\tO\nadministered\tO\nto\tO\nthe\tO\ndeveloping\tO\nfetus\tO\nto\tO\naccelerate\tO\npulmonary\tO\ndevelopment\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nif\tO\nprenatal\tO\ndexamethasone\tB-Chemical\nprogrammed\tO\na\tO\nprogressive\tO\nincrease\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nand\tO\nrenal\tB-Disease\ninjury\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nPregnant\tO\nrats\tO\nwere\tO\ngiven\tO\neither\tO\nvehicle\tO\nor\tO\n2\tO\ndaily\tO\nintraperitoneal\tO\ninjections\tO\nof\tO\ndexamethasone\tB-Chemical\n(\tO\n0\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n)\tO\non\tO\ngestational\tO\ndays\tO\n11\tO\nand\tO\n12\tO\n,\tO\n13\tO\nand\tO\n14\tO\n,\tO\n15\tO\nand\tO\n16\tO\n,\tO\n17\tO\nand\tO\n18\tO\n,\tO\nor\tO\n19\tO\nand\tO\n20\tO\n.\tO\n\nOffspring\tO\nof\tO\nrats\tO\nadministered\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\ngestation\tO\nhad\tO\na\tO\n20\tO\n%\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\ncompared\tO\nwith\tO\ncontrol\tO\nat\tO\n6\tO\nto\tO\n9\tO\nmonths\tO\nof\tO\nage\tO\n(\tO\n22\tO\n527\tO\n+\tO\n/\tO\n-\tO\n509\tO\nversus\tO\n28\tO\n050\tO\n+\tO\n/\tO\n-\tO\n561\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nwhich\tO\nwas\tO\ncomparable\tO\nto\tO\nthe\tO\npercent\tO\nreduction\tO\nin\tO\nglomeruli\tO\nmeasured\tO\nat\tO\n3\tO\nweeks\tO\nof\tO\nage\tO\n.\tO\n\nSix\tO\n-\tO\nto\tO\n9\tO\n-\tO\nmonth\tO\nold\tO\nrats\tO\nreceiving\tO\nprenatal\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n17\tO\nand\tO\n18\tO\nof\tO\ngestation\tO\nhad\tO\na\tO\n17\tO\n%\tO\nreduction\tO\nin\tO\nglomeruli\tO\n(\tO\n23\tO\n380\tO\n+\tO\n/\tO\n-\tO\n587\tO\n)\tO\ncompared\tO\nwith\tO\ncontrol\tO\nrats\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nMale\tO\nrats\tO\nthat\tO\nreceived\tO\nprenatal\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\n,\tO\n17\tO\nand\tO\n18\tO\n,\tO\nand\tO\n13\tO\nand\tO\n14\tO\nof\tO\ngestation\tO\nhad\tO\nelevated\tB-Disease\nblood\tI-Disease\npressures\tI-Disease\nat\tO\n6\tO\nmonths\tO\nof\tO\nage\tO\n;\tO\nthe\tO\nlatter\tO\ngroup\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\n.\tO\n\nAdult\tO\nrats\tO\ngiven\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\nof\tO\ngestation\tO\nhad\tO\nmore\tO\nglomeruli\tO\nwith\tO\nglomerulosclerosis\tB-Disease\nthan\tO\ncontrol\tO\nrats\tO\n.\tO\n\nThis\tO\nstudy\tO\nshows\tO\nthat\tO\nprenatal\tO\ndexamethasone\tB-Chemical\nin\tO\nrats\tO\nresults\tO\nin\tO\na\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\n,\tO\nglomerulosclerosis\tB-Disease\n,\tO\nand\tO\nhypertension\tB-Disease\nwhen\tO\nadministered\tO\nat\tO\nspecific\tO\npoints\tO\nduring\tO\ngestation\tO\n.\tO\n\nHypertension\tB-Disease\nwas\tO\nobserved\tO\nin\tO\nanimals\tO\nthat\tO\nhad\tO\na\tO\nreduction\tO\nin\tO\nglomeruli\tO\nas\tO\nwell\tO\nas\tO\nin\tO\na\tO\ngroup\tO\nthat\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\n,\tO\nsuggesting\tO\nthat\tO\na\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\nis\tO\nnot\tO\nthe\tO\nsole\tO\ncause\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nhypertension\tB-Disease\n.\tO\n\nKidney\tO\nfunction\tO\nand\tO\nmorphology\tO\nafter\tO\nshort\tO\n-\tO\nterm\tO\ncombination\tO\ntherapy\tO\nwith\tO\ncyclosporine\tB-Chemical\nA\tI-Chemical\n,\tO\ntacrolimus\tB-Chemical\nand\tO\nsirolimus\tB-Chemical\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nSirolimus\tB-Chemical\n(\tO\nSRL\tB-Chemical\n)\tO\nmay\tO\nsupplement\tO\ncalcineurin\tO\ninhibitors\tO\nin\tO\nclinical\tO\norgan\tO\ntransplantation\tO\n.\tO\n\nThese\tO\nare\tO\nnephrotoxic\tB-Disease\n,\tO\nbut\tO\nSRL\tB-Chemical\nseems\tO\nto\tO\nact\tO\ndifferently\tO\ndisplaying\tO\nonly\tO\nminor\tO\nnephrotoxic\tB-Disease\neffects\tO\n,\tO\nalthough\tO\nthis\tO\nquestion\tO\nis\tO\nstill\tO\nopen\tO\n.\tO\n\nIn\tO\na\tO\nnumber\tO\nof\tO\ntreatment\tO\nprotocols\tO\nwhere\tO\nSRL\tB-Chemical\nwas\tO\ncombined\tO\nwith\tO\na\tO\ncalcineurin\tO\ninhibitor\tO\nindications\tO\nof\tO\na\tO\nsynergistic\tO\nnephrotoxic\tB-Disease\neffect\tO\nwere\tO\ndescribed\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nfurther\tO\nthe\tO\nrenal\tO\nfunction\tO\n,\tO\nincluding\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nof\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tO\nwith\tO\neither\tO\ncyclosporine\tB-Chemical\nA\tI-Chemical\n(\tO\nCsA\tB-Chemical\n)\tO\n,\tO\ntacrolimus\tB-Chemical\n(\tO\nFK506\tB-Chemical\n)\tO\nor\tO\nSRL\tB-Chemical\nas\tO\nmonotherapies\tO\nor\tO\nin\tO\ndifferent\tO\ncombinations\tO\n.\tO\n\nMETHODS\tO\n:\tO\nFor\tO\na\tO\nperiod\tO\nof\tO\n2\tO\nweeks\tO\n,\tO\nCsA\tB-Chemical\n15\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\norally\tO\n)\tO\n,\tO\nFK506\tB-Chemical\n3\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\norally\tO\n)\tO\nor\tO\nSRL\tB-Chemical\n0\tO\n.\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\nintraperitoneally\tO\n)\tO\nwas\tO\nadministered\tO\nonce\tO\na\tO\nday\tO\nas\tO\nthese\tO\ndoses\tO\nhave\tO\nearlier\tO\nbeen\tO\nfound\tO\nto\tO\nachieve\tO\na\tO\nsignificant\tO\nimmunosuppressive\tO\neffect\tO\nin\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\n.\tO\n\nIn\tO\nthe\tO\n'\tO\nconscious\tO\ncatheterized\tO\nrat\tO\n'\tO\nmodel\tO\n,\tO\nthe\tO\nglomerular\tO\nfiltration\tO\nrate\tO\n(\tO\nGFR\tO\n)\tO\nwas\tO\nmeasured\tO\nas\tO\nthe\tO\nclearance\tO\nof\tO\nCr\tO\n(\tO\nEDTA\tO\n)\tO\n.\tO\n\nThe\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nincluded\tO\na\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nsystem\tO\nanalysing\tO\nthe\tO\ndegree\tO\nof\tO\nstriped\tO\nfibrosis\tB-Disease\n,\tO\nsubcapsular\tO\nfibrosis\tB-Disease\nand\tO\nthe\tO\nnumber\tO\nof\tO\nbasophilic\tO\ntubules\tO\n,\tO\nplus\tO\nan\tO\nadditional\tO\nstereological\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tO\ngrade\tO\nof\tO\nfibrosis\tB-Disease\nin\tO\nthe\tO\ncortex\tO\nstained\tO\nwith\tO\nSirius\tO\nRed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nCsA\tB-Chemical\n,\tO\nFK506\tB-Chemical\nand\tO\nSRL\tB-Chemical\nall\tO\nsignificantly\tO\ndecreased\tO\nthe\tO\nGFR\tO\n.\tO\n\nA\tO\nfurther\tO\ndeterioration\tO\nwas\tO\nseen\tO\nwhen\tO\nCsA\tB-Chemical\nwas\tO\ncombined\tO\nwith\tO\neither\tO\nFK506\tB-Chemical\nor\tO\nSRL\tB-Chemical\n,\tO\nwhereas\tO\nthe\tO\nGFR\tO\nremained\tO\nunchanged\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nFK506\tB-Chemical\nplus\tO\nSRL\tB-Chemical\nwhen\tO\ncompared\tO\nwith\tO\ntreatment\tO\nwith\tO\nany\tO\nof\tO\nthe\tO\nsingle\tO\nsubstances\tO\n.\tO\n\nThe\tO\nmorphological\tO\nchanges\tO\npresented\tO\na\tO\nsimilar\tO\npattern\tO\n.\tO\n\nThe\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nwas\tO\nsignificantly\tO\nworst\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nCsA\tB-Chemical\nplus\tO\nSRL\tB-Chemical\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\ncompared\tO\nwith\tO\ncontrols\tO\n)\tO\nand\tO\nthe\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tO\ngrade\tO\nof\tO\nfibrosis\tB-Disease\nalso\tO\nshowed\tO\nthe\tO\nhighest\tO\nproportion\tO\nin\tO\nthe\tO\nsame\tO\ngroup\tO\nand\tO\nwas\tO\nsignificantly\tO\ndifferent\tO\nfrom\tO\ncontrols\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nThe\tO\nFK506\tB-Chemical\nplus\tO\nSRL\tB-Chemical\ncombination\tO\nshowed\tO\nonly\tO\na\tO\nmarginally\tO\nhigher\tO\ndegree\tO\nof\tO\nfibrosis\tB-Disease\nas\tO\ncompared\tO\nwith\tO\ncontrols\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nrat\tO\nstudy\tO\ndemonstrated\tO\na\tO\nsynergistic\tO\nnephrotoxic\tB-Disease\neffect\tO\nof\tO\nCsA\tB-Chemical\nplus\tO\nSRL\tB-Chemical\n,\tO\nwhereas\tO\nFK506\tB-Chemical\nplus\tO\nSRL\tB-Chemical\nwas\tO\nbetter\tO\ntolerated\tO\n.\tO\n\nEvaluation\tO\nof\tO\ncardiac\tO\ntroponin\tO\nI\tO\nand\tO\nT\tO\nlevels\tO\nas\tO\nmarkers\tO\nof\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nin\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\nrats\tO\n,\tO\nand\tO\ntheir\tO\nrelationship\tO\nwith\tO\nechocardiographic\tO\nand\tO\nhistological\tO\nfindings\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCardiac\tO\ntroponins\tO\nI\tO\n(\tO\ncTnI\tO\n)\tO\nand\tO\nT\tO\n(\tO\ncTnT\tO\n)\tO\nhave\tO\nbeen\tO\nshown\tO\nto\tO\nbe\tO\nhighly\tO\nsensitive\tO\nand\tO\nspecific\tO\nmarkers\tO\nof\tO\nmyocardial\tB-Disease\ncell\tI-Disease\ninjury\tI-Disease\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\ndiagnostic\tO\nvalue\tO\nof\tO\ncTnI\tO\nand\tO\ncTnT\tO\nfor\tO\nthe\tO\ndiagnosis\tO\nof\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\n,\tO\nand\tO\nwe\tO\nexamined\tO\nthe\tO\nrelationship\tO\nbetween\tO\nserial\tO\ncTnI\tO\nand\tO\ncTnT\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\ncardiac\tB-Disease\ndisorders\tI-Disease\nmonitored\tO\nby\tO\nechocardiography\tO\nand\tO\nhistological\tO\nexaminations\tO\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThirty\tO\n-\tO\nfive\tO\nWistar\tO\nrats\tO\nwere\tO\ngiven\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nDOX\tB-Chemical\n,\tO\ni\tO\n.\tO\nv\tO\n.\tO\n,\tO\nweekly\tO\nfor\tO\nup\tO\nto\tO\n8\tO\nweeks\tO\nfor\tO\na\tO\ntotal\tO\ncumulative\tO\ndose\tO\nof\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n.\tO\n\nTen\tO\nrats\tO\nreceived\tO\nsaline\tO\nas\tO\na\tO\ncontrol\tO\ngroup\tO\n.\tO\n\ncTnI\tO\nwas\tO\nmeasured\tO\nwith\tO\nAccess\tO\n(\tO\nR\tO\n)\tO\n(\tO\nng\tO\n/\tO\nml\tO\n)\tO\nand\tO\na\tO\nresearch\tO\nimmunoassay\tO\n(\tO\npg\tO\n/\tO\nml\tO\n)\tO\n,\tO\nand\tO\ncompared\tO\nwith\tO\ncTnT\tO\n,\tO\nCK\tO\n-\tO\nMB\tO\nmass\tO\nand\tO\nCK\tO\n.\tO\n\nBy\tO\nusing\tO\ntransthoracic\tO\nechocardiography\tO\n,\tO\nanterior\tO\nand\tO\nposterior\tO\nwall\tO\nthickness\tO\n,\tO\nLV\tO\ndiameters\tO\nand\tO\nLV\tO\nfractional\tO\nshortening\tO\n(\tO\nFS\tO\n)\tO\nwere\tO\nmeasured\tO\nin\tO\nall\tO\nrats\tO\nbefore\tO\nDOX\tB-Chemical\nor\tO\nsaline\tO\n,\tO\nand\tO\nat\tO\nweeks\tO\n6\tO\nand\tO\n9\tO\nafter\tO\ntreatment\tO\nin\tO\nall\tO\nsurviving\tO\nrats\tO\n.\tO\n\nHistology\tO\nwas\tO\nperformed\tO\nin\tO\nDOX\tB-Chemical\n-\tO\nrats\tO\nat\tO\n6\tO\nand\tO\n9\tO\nweeks\tO\nafter\tO\nthe\tO\nlast\tO\nDOX\tB-Chemical\ndose\tO\nand\tO\nin\tO\nall\tO\ncontrols\tO\n.\tO\n\nRESULTS\tO\n:\tO\nEighteen\tO\nof\tO\nthe\tO\nDOX\tB-Chemical\nrats\tO\ndied\tO\nprematurely\tO\nof\tO\ngeneral\tO\ntoxicity\tB-Disease\nduring\tO\nthe\tO\n9\tO\n-\tO\nweek\tO\nperiod\tO\n.\tO\n\nEnd\tO\n-\tO\ndiastolic\tO\n(\tO\nED\tO\n)\tO\nand\tO\nend\tO\n-\tO\nsystolic\tO\n(\tO\nES\tO\n)\tO\nLV\tO\ndiameters\tO\n/\tO\nBW\tO\nsignificantly\tO\nincreased\tO\n,\tO\nwhereas\tO\nLV\tO\nFS\tO\nwas\tO\ndecreased\tO\nafter\tO\n9\tO\nweeks\tO\nin\tO\nthe\tO\nDOX\tB-Chemical\ngroup\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThese\tO\nparameters\tO\nremained\tO\nunchanged\tO\nin\tO\ncontrols\tO\n.\tO\n\nHistological\tO\nevaluation\tO\nof\tO\nhearts\tO\nfrom\tO\nall\tO\nrats\tO\ngiven\tO\nDOX\tB-Chemical\nrevealed\tO\nsignificant\tO\nslight\tO\ndegrees\tO\nof\tO\nperivascular\tO\nand\tO\ninterstitial\tO\nfibrosis\tB-Disease\n.\tO\n\nIn\tO\n7\tO\nof\tO\nthe\tO\n18\tO\nrats\tO\n,\tO\ndegeneration\tO\nand\tO\nmyocyte\tO\nvacuolisation\tO\nwere\tO\nfound\tO\n.\tO\n\nOnly\tO\nfive\tO\nof\tO\nthe\tO\ncontrols\tO\nexhibited\tO\nevidence\tO\nof\tO\nvery\tO\nslight\tO\nperivascular\tO\nfibrosis\tB-Disease\n.\tO\n\nA\tO\nsignificant\tO\nrise\tO\nin\tO\ncTnT\tO\nwas\tO\nfound\tO\nin\tO\nDOX\tB-Chemical\nrats\tO\nafter\tO\ncumulative\tO\ndoses\tO\nof\tO\n7\tO\n.\tO\n5\tO\nand\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nin\tO\ncomparison\tO\nwith\tO\nbaseline\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\ncTnT\tO\nfound\tO\nin\tO\nrats\tO\nafter\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nwere\tO\nsignificantly\tO\ngreater\tO\nthan\tO\nthat\tO\nfound\tO\nafter\tO\n7\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nDOX\tB-Chemical\n.\tO\n\nMaximal\tO\ncTnI\tO\n(\tO\npg\tO\n/\tO\nml\tO\n)\tO\nand\tO\ncTnT\tO\nlevels\tO\nwere\tO\nsignificantly\tO\nincreased\tO\nin\tO\nDOX\tB-Chemical\nrats\tO\ncompared\tO\nwith\tO\ncontrols\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n006\tO\n,\tO\n0\tO\n.\tO\n007\tO\n)\tO\n.\tO\n\ncTnI\tO\n(\tO\nng\tO\n/\tO\nml\tO\n)\tO\n,\tO\nCK\tO\n-\tO\nMB\tO\nmass\tO\nand\tO\nCK\tO\nremained\tO\nunchanged\tO\nin\tO\nDOX\tB-Chemical\nrats\tO\ncompared\tO\nwith\tO\ncontrols\tO\n.\tO\n\nAll\tO\nmarkers\tO\nremained\tO\nstable\tO\nin\tO\ncontrols\tO\n.\tO\n\nAnalysis\tO\nof\tO\ndata\tO\nrevealed\tO\na\tO\nsignificant\tO\ncorrelation\tO\nbetween\tO\nmaximal\tO\ncTnT\tO\nand\tO\nED\tO\nand\tO\nES\tO\nLV\tO\ndiameters\tO\n/\tO\nBW\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n81\tO\nand\tO\n0\tO\n.\tO\n65\tO\n;\tO\np\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nA\tO\nsignificant\tO\nrelationship\tO\nwas\tO\nobserved\tO\nbetween\tO\nmaximal\tO\ncTnT\tO\nand\tO\nthe\tO\nextent\tO\nof\tO\nmyocardial\tO\nmorphological\tO\nchanges\tO\n,\tO\nand\tO\nbetween\tO\nLV\tO\ndiameters\tO\n/\tO\nBW\tO\nand\tO\nhistological\tO\nfindings\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAmong\tO\nmarkers\tO\nof\tO\nischemic\tB-Disease\ninjury\tI-Disease\nafter\tO\nDOX\tB-Chemical\nin\tO\nrats\tO\n,\tO\ncTnT\tO\nshowed\tO\nthe\tO\ngreatest\tO\nability\tO\nto\tO\ndetect\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nassessed\tO\nby\tO\nechocardiographic\tO\ndetection\tO\nand\tO\nhistological\tO\nchanges\tO\n.\tO\n\nAlthough\tO\nthere\tO\nwas\tO\na\tO\ndiscrepancy\tO\nbetween\tO\nthe\tO\namount\tO\nof\tO\ncTnI\tO\nand\tO\ncTnT\tO\nafter\tO\nDOX\tB-Chemical\n,\tO\nprobably\tO\ndue\tO\nto\tO\nheterogeneity\tO\nin\tO\ncross\tO\n-\tO\nreactivities\tO\nof\tO\nmAbs\tO\nto\tO\nvarious\tO\ncTnI\tO\nand\tO\ncTnT\tO\nforms\tO\n,\tO\nit\tO\nis\tO\nlikely\tO\nthat\tO\ncTnT\tO\nin\tO\nrats\tO\nafter\tO\nDOX\tB-Chemical\nindicates\tO\ncell\tO\ndamage\tO\ndetermined\tO\nby\tO\nthe\tO\nmagnitude\tO\nof\tO\ninjury\tO\ninduced\tO\nand\tO\nthat\tO\ncTnT\tO\nshould\tO\nbe\tO\na\tO\nuseful\tO\nmarker\tO\nfor\tO\nthe\tO\nprediction\tO\nof\tO\nexperimentally\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nand\tO\npossibly\tO\nfor\tO\ncardioprotective\tO\nexperiments\tO\n.\tO\n\nOctreotide\tB-Chemical\n-\tO\ninduced\tO\nhypoxemia\tB-Disease\nand\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nin\tO\npremature\tO\nneonates\tO\n.\tO\n\nThe\tO\nauthors\tO\nreport\tO\n2\tO\ncases\tO\nof\tO\npremature\tO\nneonates\tO\nwho\tO\nhad\tO\nenterocutaneous\tO\nfistula\tB-Disease\ncomplicating\tO\nnecrotizing\tB-Disease\nenterocolitis\tI-Disease\n.\tO\n\nPulmonary\tB-Disease\nhypertension\tI-Disease\ndeveloped\tO\nafter\tO\nadministration\tO\nof\tO\na\tO\nsomatostatin\tO\nanalogue\tO\n,\tO\noctreotide\tB-Chemical\n,\tO\nto\tO\nenhance\tO\nresolution\tO\nof\tO\nthe\tO\nfistula\tB-Disease\n.\tO\n\nThe\tO\nauthors\tO\ndiscuss\tO\nthe\tO\nmechanism\tO\nof\tO\nthe\tO\noccurrence\tO\nof\tO\nthis\tO\ncomplication\tO\nand\tO\nrecommend\tO\ncaution\tO\nof\tO\nits\tO\nuse\tO\nin\tO\nhigh\tO\n-\tO\nrisk\tO\npremature\tO\nneonates\tO\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\nin\tO\nwomen\tO\nprescribed\tO\ncyproterone\tB-Chemical\nacetate\tI-Chemical\nin\tO\ncombination\tO\nwith\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n:\tO\na\tO\nnested\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tB-Chemical\nacetate\tI-Chemical\ncombined\tO\nwith\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n(\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\n)\tO\nis\tO\nlicensed\tO\nin\tO\nthe\tO\nUK\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nwomen\tO\nwith\tO\nacne\tB-Disease\nand\tO\nhirsutism\tB-Disease\nand\tO\nis\tO\nalso\tO\na\tO\ntreatment\tO\noption\tO\nfor\tO\npolycystic\tB-Disease\novary\tI-Disease\nsyndrome\tI-Disease\n(\tO\nPCOS\tB-Disease\n)\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tB-Disease\n)\tO\nassociated\tO\nwith\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\ncompared\tO\nwith\tO\nconventional\tO\ncombined\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n(\tO\nCOCs\tO\n)\tO\n.\tO\n\nWe\tO\nbelieve\tO\nthe\tO\nresults\tO\nof\tO\nthose\tO\nstudies\tO\nmay\tO\nhave\tO\nbeen\tO\naffected\tO\nby\tO\nresidual\tO\nconfounding\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nthe\tO\nGeneral\tO\nPractice\tO\nResearch\tO\nDatabase\tO\nwe\tO\nconducted\tO\na\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nnested\tO\nwithin\tO\na\tO\npopulation\tO\nof\tO\nwomen\tO\naged\tO\nbetween\tO\n15\tO\nand\tO\n39\tO\nyears\tO\nwith\tO\nacne\tB-Disease\n,\tO\nhirsutism\tB-Disease\nor\tO\nPCOS\tB-Disease\nto\tO\nestimate\tO\nthe\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nassociated\tO\nwith\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nage\tO\n-\tO\nadjusted\tO\nincidence\tO\nrate\tO\nratio\tO\nfor\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\nversus\tO\nconventional\tO\nCOCs\tO\nwas\tO\n2\tO\n.\tO\n20\tO\n[\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n(\tO\nCI\tO\n)\tO\n1\tO\n.\tO\n35\tO\n-\tO\n3\tO\n.\tO\n58\tO\n]\tO\n.\tO\n\nUsing\tO\nas\tO\nthe\tO\nreference\tO\ngroup\tO\nwomen\tO\nwho\tO\nwere\tO\nnot\tO\nusing\tO\noral\tO\ncontraception\tO\n,\tO\nhad\tO\nno\tO\nrecent\tO\npregnancy\tO\nor\tO\nmenopausal\tO\nsymptoms\tO\n,\tO\nthe\tO\ncase\tO\n-\tO\ncontrol\tO\nanalysis\tO\ngave\tO\nan\tO\nadjusted\tO\nodds\tO\nratio\tO\n(\tO\nOR\tO\n(\tO\nadj\tO\n)\tO\n)\tO\nof\tO\n7\tO\n.\tO\n44\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n3\tO\n.\tO\n67\tO\n-\tO\n15\tO\n.\tO\n08\tO\n)\tO\nfor\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\nuse\tO\ncompared\tO\nwith\tO\nan\tO\nOR\tO\n(\tO\nadj\tO\n)\tO\nof\tO\n2\tO\n.\tO\n58\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n60\tO\n-\tO\n4\tO\n.\tO\n18\tO\n)\tO\nfor\tO\nuse\tO\nof\tO\nconventional\tO\nCOCs\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\nin\tO\nwomen\tO\nwith\tO\nacne\tB-Disease\n,\tO\nhirsutism\tB-Disease\nor\tO\nPCOS\tB-Disease\nalthough\tO\nresidual\tO\nconfounding\tO\nby\tO\nindication\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\ntreatment\tO\nwith\tO\ngum\tB-Chemical\nArabic\tI-Chemical\non\tO\ngentamicin\tB-Chemical\nnephrotoxicity\tB-Disease\nin\tO\nrats\tO\n:\tO\na\tO\npreliminary\tO\nstudy\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nwork\tO\nwe\tO\nassessed\tO\nthe\tO\neffect\tO\nof\tO\ntreatment\tO\nof\tO\nrats\tO\nwith\tO\ngum\tB-Chemical\nArabic\tI-Chemical\non\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\ninduced\tO\nby\tO\ngentamicin\tB-Chemical\n(\tO\nGM\tB-Chemical\n)\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nRats\tO\nwere\tO\ntreated\tO\nwith\tO\nthe\tO\nvehicle\tO\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\ndistilled\tO\nwater\tO\nand\tO\n5\tO\n%\tO\nw\tO\n/\tO\nv\tO\ncellulose\tO\n,\tO\n10\tO\ndays\tO\n)\tO\n,\tO\ngum\tB-Chemical\nArabic\tI-Chemical\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\na\tO\n10\tO\n%\tO\nw\tO\n/\tO\nv\tO\naqueous\tO\nsuspension\tO\nof\tO\ngum\tB-Chemical\nArabic\tI-Chemical\npowder\tO\n,\tO\norally\tO\nfor\tO\n10\tO\ndays\tO\n)\tO\n,\tO\nor\tO\ngum\tB-Chemical\nArabic\tI-Chemical\nconcomitantly\tO\nwith\tO\nGM\tB-Chemical\n(\tO\n80mg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nintramuscularly\tO\n,\tO\nduring\tO\nthe\tO\nlast\tO\nsix\tO\ndays\tO\nof\tO\nthe\tO\ntreatment\tO\nperiod\tO\n)\tO\n.\tO\n\nNephrotoxicity\tB-Disease\nwas\tO\nassessed\tO\nby\tO\nmeasuring\tO\nthe\tO\nconcentrations\tO\nof\tO\ncreatinine\tB-Chemical\nand\tO\nurea\tB-Chemical\nin\tO\nthe\tO\nplasma\tO\nand\tO\nreduced\tO\nglutathione\tB-Chemical\n(\tO\nGSH\tB-Chemical\n)\tO\nin\tO\nthe\tO\nkidney\tO\ncortex\tO\n,\tO\nand\tO\nby\tO\nlight\tO\nmicroscopic\tO\nexamination\tO\nof\tO\nkidney\tO\nsections\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ngum\tB-Chemical\nArabic\tI-Chemical\nand\tO\nGM\tB-Chemical\nsignificantly\tO\nincreased\tO\ncreatinine\tB-Chemical\nand\tO\nurea\tB-Chemical\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tB-Chemical\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tB-Chemical\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tB-Chemical\ngroup\tO\n)\tO\nThe\tO\nGM\tB-Chemical\n-\tO\ninduced\tO\nproximal\tO\ntubular\tB-Disease\nnecrosis\tI-Disease\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tB-Chemical\ntogether\tO\nwith\tO\ngum\tB-Chemical\nArabic\tI-Chemical\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tB-Chemical\nand\tO\ncellulose\tO\n.\tO\n\nIt\tO\ncould\tO\nbe\tO\ninferred\tO\nthat\tO\ngum\tB-Chemical\nArabic\tI-Chemical\ntreatment\tO\nhas\tO\ninduced\tO\na\tO\nmodest\tO\namelioration\tO\nof\tO\nsome\tO\nof\tO\nthe\tO\nhistological\tO\nand\tO\nbiochemical\tO\nindices\tO\nof\tO\nGM\tB-Chemical\nnephrotoxicity\tB-Disease\n.\tO\n\nFurther\tO\nwork\tO\nis\tO\nwarranted\tO\non\tO\nthe\tO\neffect\tO\nof\tO\nthe\tO\ntreatments\tO\non\tO\nrenal\tO\nfunctional\tO\naspects\tO\nin\tO\nmodels\tO\nof\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nand\tO\non\tO\nthe\tO\nmechanism\tO\n(\tO\ns\tO\n)\tO\ninvolved\tO\n.\tO\n\nIncreased\tO\nfrequency\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\nwith\tO\nthe\tO\ncombination\tO\nof\tO\ndocetaxel\tB-Chemical\nand\tO\nthalidomide\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nmetastatic\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nfrequency\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tB-Disease\n)\tO\nin\tO\npatients\tO\nwith\tO\nadvanced\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tB-Disease\ncancer\tI-Disease\nwho\tO\nwere\tO\ntreated\tO\nwith\tO\ndocetaxel\tB-Chemical\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nthalidomide\tB-Chemical\n.\tO\n\nDESIGN\tO\n:\tO\nRetrospective\tO\nanalysis\tO\nof\tO\na\tO\nrandomized\tO\nphase\tO\nII\tO\ntrial\tO\n.\tO\n\nSETTING\tO\n:\tO\nNational\tO\nInstitutes\tO\nof\tO\nHealth\tO\nclinical\tO\nresearch\tO\ncenter\tO\n.\tO\n\nPATIENTS\tO\n:\tO\nSeventy\tO\nmen\tO\n,\tO\naged\tO\n50\tO\n-\tO\n80\tO\nyears\tO\n,\tO\nwith\tO\nadvanced\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nINTERVENTION\tO\n:\tO\nEach\tO\npatient\tO\nreceived\tO\neither\tO\nintravenous\tO\ndocetaxel\tB-Chemical\n30\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nweek\tO\nfor\tO\n3\tO\nconsecutive\tO\nweeks\tO\n,\tO\nfollowed\tO\nby\tO\n1\tO\nweek\tO\noff\tO\n,\tO\nor\tO\nthe\tO\ncombination\tO\nof\tO\ncontinuous\tO\noral\tO\nthalidomide\tB-Chemical\n200\tO\nmg\tO\nevery\tO\nevening\tO\nplus\tO\nthe\tO\nsame\tO\ndocetaxel\tB-Chemical\nregimen\tO\n.\tO\n\nThis\tO\n4\tO\n-\tO\nweek\tO\ncycle\tO\nwas\tO\nrepeated\tO\nuntil\tO\nthere\tO\nwas\tO\nevidence\tO\nof\tO\nexcessive\tO\ntoxicity\tB-Disease\nor\tO\ndisease\tO\nprogression\tO\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nNone\tO\nof\tO\n23\tO\npatients\tO\nwho\tO\nreceived\tO\ndocetaxel\tB-Chemical\nalone\tO\ndeveloped\tO\nVTE\tB-Disease\n,\tO\nwhereas\tO\n9\tO\nof\tO\n47\tO\npatients\tO\n(\tO\n19\tO\n%\tO\n)\tO\nwho\tO\nreceived\tO\ndocetaxel\tB-Chemical\nplus\tO\nthalidomide\tB-Chemical\ndeveloped\tO\nVTE\tB-Disease\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\naddition\tO\nof\tO\nthalidomide\tB-Chemical\nto\tO\ndocetaxel\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nprostate\tB-Disease\ncancer\tI-Disease\nsignificantly\tO\nincreases\tO\nthe\tO\nfrequency\tO\nof\tO\nVTE\tB-Disease\n.\tO\n\nClinicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\npotential\tO\ncomplication\tO\nwhen\tO\nadding\tO\nthalidomide\tB-Chemical\nto\tO\nchemotherapeutic\tO\nregimens\tO\n.\tO\n\nTiclopidine\tB-Chemical\n-\tO\ninduced\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\n2\tO\ncases\tO\nof\tO\nticlopidine\tB-Chemical\n-\tO\ninduced\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n,\tO\ninvestigate\tO\nits\tO\nmechanism\tO\n,\tO\nand\tO\ncompare\tO\nthe\tO\nobserved\tO\nmain\tO\ncharacteristics\tO\nwith\tO\nthose\tO\nof\tO\nthe\tO\npublished\tO\ncases\tO\n.\tO\n\nCASE\tO\nSUMMARIES\tO\n:\tO\nTwo\tO\npatients\tO\ndeveloped\tO\nprolonged\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\nafter\tO\nreceiving\tO\nticlopidine\tB-Chemical\nfollowing\tO\npercutaneous\tO\ncoronary\tO\nangioplasty\tO\n,\tO\nwith\tO\ncomplete\tO\nremission\tO\nduring\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n.\tO\n\nT\tO\n-\tO\ncell\tO\nstimulation\tO\nby\tO\ntherapeutic\tO\nconcentration\tO\nof\tO\nticlopidine\tB-Chemical\nwas\tO\ndemonstrated\tO\nin\tO\nvitro\tO\nin\tO\nthe\tO\npatients\tO\n,\tO\nbut\tO\nnot\tO\nin\tO\nhealthy\tO\ncontrols\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nCholestatic\tB-Disease\nhepatitis\tI-Disease\nis\tO\na\tO\nrare\tO\ncomplication\tO\nof\tO\nthe\tO\nantiplatelet\tO\nagent\tO\nticlopidine\tB-Chemical\n;\tO\nseveral\tO\ncases\tO\nhave\tO\nbeen\tO\nreported\tO\nbut\tO\nfew\tO\nin\tO\nthe\tO\nEnglish\tO\nliterature\tO\n.\tO\n\nOur\tO\npatients\tO\ndeveloped\tO\njaundice\tB-Disease\nfollowing\tO\ntreatment\tO\nwith\tO\nticlopidine\tB-Chemical\nand\tO\nshowed\tO\nthe\tO\nclinical\tO\nand\tO\nlaboratory\tO\ncharacteristics\tO\nof\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n,\tO\nwhich\tO\nresolved\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nHepatitis\tB-Disease\nmay\tO\ndevelop\tO\nweeks\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nand\tO\nmay\tO\nrun\tO\na\tO\nprolonged\tO\ncourse\tO\n,\tO\nbut\tO\ncomplete\tO\nremission\tO\nwas\tO\nobserved\tO\nin\tO\nall\tO\nreported\tO\ncases\tO\n.\tO\n\nAn\tO\nobjective\tO\ncausality\tO\nassessment\tO\nrevealed\tO\nthat\tO\nthe\tO\nadverse\tO\ndrug\tO\nevent\tO\nwas\tO\nprobably\tO\nrelated\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\nticlopidine\tB-Chemical\n.\tO\n\nThe\tO\nmechanisms\tO\nof\tO\nthis\tO\nticlopidine\tB-Chemical\n-\tO\ninduced\tO\ncholestasis\tB-Disease\nare\tO\nunclear\tO\n.\tO\n\nImmune\tO\nmechanisms\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\ndrug\tO\n'\tO\ns\tO\nhepatotoxicity\tB-Disease\n,\tO\nas\tO\nsuggested\tO\nby\tO\nthe\tO\nT\tO\n-\tO\ncell\tO\nstimulation\tO\nstudy\tO\nreported\tO\nhere\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCholestatic\tB-Disease\nhepatitis\tI-Disease\nis\tO\na\tO\nrare\tO\nadverse\tO\neffect\tO\nof\tO\nticlopidine\tB-Chemical\nthat\tO\nmay\tO\nbe\tO\nimmune\tO\nmediated\tO\n.\tO\n\nPatients\tO\nreceiving\tO\nthe\tO\ndrug\tO\nshould\tO\nbe\tO\nmonitored\tO\nwith\tO\nliver\tO\nfunction\tO\ntests\tO\nalong\tO\nwith\tO\ncomplete\tO\nblood\tO\ncell\tO\ncounts\tO\n.\tO\n\nThis\tO\ncomplication\tO\nwill\tO\nbe\tO\nobserved\tO\neven\tO\nless\tO\noften\tO\nin\tO\nthe\tO\nfuture\tO\nas\tO\nticlopidine\tB-Chemical\nis\tO\nbeing\tO\nreplaced\tO\nby\tO\nthe\tO\nnewer\tO\nantiplatelet\tO\nagent\tO\nclopidogrel\tB-Chemical\n.\tO\n\nEpithelial\tO\nsodium\tB-Chemical\nchannel\tO\n(\tO\nENaC\tO\n)\tO\nsubunit\tO\nmRNA\tO\nand\tO\nprotein\tO\nexpression\tO\nin\tO\nrats\tO\nwith\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nIn\tO\nexperimental\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n,\tO\nurinary\tO\nsodium\tB-Chemical\nexcretion\tO\nis\tO\ndecreased\tO\nduring\tO\nthe\tO\nearly\tO\nphase\tO\nof\tO\nthe\tO\ndisease\tO\n.\tO\n\nThe\tO\nmolecular\tO\nmechanism\tO\n(\tO\ns\tO\n)\tO\nleading\tO\nto\tO\nsalt\tO\nretention\tO\nhas\tO\nnot\tO\nbeen\tO\ncompletely\tO\nelucidated\tO\n.\tO\n\nThe\tO\nrate\tO\n-\tO\nlimiting\tO\nconstituent\tO\nof\tO\ncollecting\tO\nduct\tO\nsodium\tB-Chemical\ntransport\tO\nis\tO\nthe\tO\nepithelial\tO\nsodium\tB-Chemical\nchannel\tO\n(\tO\nENaC\tO\n)\tO\n.\tO\n\nWe\tO\nexamined\tO\nthe\tO\nabundance\tO\nof\tO\nENaC\tO\nsubunit\tO\nmRNAs\tO\nand\tO\nproteins\tO\nin\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\ntime\tO\ncourses\tO\nof\tO\nurinary\tO\nsodium\tB-Chemical\nexcretion\tO\n,\tO\nplasma\tO\naldosterone\tB-Chemical\nconcentration\tO\nand\tO\nproteinuria\tB-Disease\nwere\tO\nstudied\tO\nin\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tO\nwith\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\neither\tO\nPAN\tB-Chemical\nor\tO\nvehicle\tO\n.\tO\n\nThe\tO\nrelative\tO\namounts\tO\nof\tO\nalphaENaC\tO\n,\tO\nbetaENaC\tO\nand\tO\ngammaENaC\tO\nmRNAs\tO\nwere\tO\ndetermined\tO\nin\tO\nkidneys\tO\nfrom\tO\nthese\tO\nrats\tO\nby\tO\nreal\tO\n-\tO\ntime\tO\nquantitative\tO\nTaqMan\tO\nPCR\tO\n,\tO\nand\tO\nthe\tO\namounts\tO\nof\tO\nproteins\tO\nby\tO\nWestern\tO\nblot\tO\n.\tO\n\nThe\tO\nkinetics\tO\nof\tO\nurinary\tO\nsodium\tB-Chemical\nexcretion\tO\nand\tO\nthe\tO\nappearance\tO\nof\tO\nproteinuria\tB-Disease\nwere\tO\ncomparable\tO\nwith\tO\nthose\tO\nreported\tO\npreviously\tO\n.\tO\n\nSodium\tB-Chemical\nretention\tO\noccurred\tO\non\tO\ndays\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nafter\tO\nPAN\tB-Chemical\ninjection\tO\n.\tO\n\nA\tO\nsignificant\tO\nup\tO\n-\tO\nregulation\tO\nof\tO\nalphaENaC\tO\nand\tO\nbetaENaC\tO\nmRNA\tO\nabundance\tO\non\tO\ndays\tO\n1\tO\nand\tO\n2\tO\npreceded\tO\nsodium\tB-Chemical\nretention\tO\non\tO\ndays\tO\n2\tO\nand\tO\n3\tO\n.\tO\n\nConversely\tO\n,\tO\ndown\tO\n-\tO\nregulation\tO\nof\tO\nalphaENaC\tO\n,\tO\nbetaENaC\tO\nand\tO\ngammaENaC\tO\nmRNA\tO\nexpression\tO\non\tO\nday\tO\n3\tO\noccurred\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nhigh\tO\naldosterone\tB-Chemical\nconcentrations\tO\n,\tO\nand\tO\nwas\tO\nfollowed\tO\nby\tO\na\tO\nreturn\tO\nof\tO\nsodium\tB-Chemical\nexcretion\tO\nto\tO\ncontrol\tO\nvalues\tO\n.\tO\n\nThe\tO\namounts\tO\nof\tO\nalphaENaC\tO\n,\tO\nbetaENaC\tO\nand\tO\ngammaENaC\tO\nproteins\tO\nwere\tO\nnot\tO\nincreased\tO\nduring\tO\nPAN\tB-Chemical\n-\tO\ninduced\tO\nsodium\tB-Chemical\nretention\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nENaC\tO\nmRNA\tO\nexpression\tO\n,\tO\nespecially\tO\nalphaENaC\tO\n,\tO\nis\tO\nincreased\tO\nin\tO\nthe\tO\nvery\tO\nearly\tO\nphase\tO\nof\tO\nthe\tO\nexperimental\tO\nmodel\tO\nof\tO\nPAN\tB-Chemical\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\nin\tO\nrats\tO\n,\tO\nbut\tO\nappears\tO\nto\tO\nescape\tO\nfrom\tO\nthe\tO\nregulation\tO\nby\tO\naldosterone\tB-Chemical\nafter\tO\nday\tO\n3\tO\n.\tO\n\nSub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\ngamma\tB-Chemical\n-\tI-Chemical\nvinyl\tI-Chemical\nGABA\tI-Chemical\n(\tO\nvigabatrin\tB-Chemical\n)\tO\ninhibits\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\ndopamine\tB-Chemical\n.\tO\n\nRATIONALE\tO\n:\tO\ngamma\tB-Chemical\n-\tI-Chemical\nVinyl\tI-Chemical\nGABA\tI-Chemical\n(\tO\nGVG\tB-Chemical\n)\tO\nirreversibly\tO\ninhibits\tO\nGABA\tB-Chemical\n-\tO\ntransaminase\tO\n.\tO\n\nThis\tO\nnon\tO\n-\tO\nreceptor\tO\nmediated\tO\ninhibition\tO\nrequires\tO\nde\tO\nnovo\tO\nsynthesis\tO\nfor\tO\nrestoration\tO\nof\tO\nfunctional\tO\nGABA\tB-Chemical\ncatabolism\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nGiven\tO\nits\tO\npreclinical\tO\nsuccess\tO\nfor\tO\ntreating\tO\nsubstance\tB-Disease\nabuse\tI-Disease\nand\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\nvisual\tB-Disease\nfield\tI-Disease\ndefects\tI-Disease\n(\tO\nVFD\tB-Disease\n)\tO\nassociated\tO\nwith\tO\ncumulative\tO\nlifetime\tO\nexposure\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\neffects\tO\nof\tO\nsub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tB-Chemical\non\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\n(\tO\nNAcc\tO\n)\tO\ndopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nin\tO\nvivo\tO\nmicrodialysis\tO\n,\tO\nwe\tO\ncompared\tO\nacute\tO\nexposure\tO\n(\tO\n450\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nto\tO\nan\tO\nidentical\tO\nsub\tO\n-\tO\nchronic\tO\nexposure\tO\n(\tO\n150\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\nfor\tO\n3\tO\ndays\tO\n)\tO\n,\tO\nfollowed\tO\nby\tO\n1\tO\n-\tO\nor\tO\n3\tO\n-\tO\nday\tO\nwashout\tO\n.\tO\n\nFinally\tO\n,\tO\nwe\tO\nexamined\tO\nthe\tO\nlow\tO\ndose\tO\nof\tO\n150\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\n)\tO\nusing\tO\na\tO\nsimilar\tO\nwashout\tO\nperiod\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSub\tO\n-\tO\nchronic\tO\nGVG\tB-Chemical\nexposure\tO\ninhibited\tO\nthe\tO\neffect\tO\nof\tO\ncocaine\tB-Chemical\nfor\tO\n3\tO\ndays\tO\n,\tO\nwhich\tO\nexceeded\tO\nin\tO\nmagnitude\tO\nand\tO\nduration\tO\nthe\tO\nidentical\tO\nacute\tO\ndose\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tB-Chemical\npotentiates\tO\nand\tO\nextends\tO\nthe\tO\ninhibition\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nincreases\tO\nin\tO\ndopamine\tB-Chemical\n,\tO\neffectively\tO\nreducing\tO\ncumulative\tO\nexposures\tO\nand\tO\nthe\tO\nrisk\tO\nfor\tO\nVFDS\tO\n.\tO\n\nMR\tO\nimaging\tO\nwith\tO\nquantitative\tO\ndiffusion\tO\nmapping\tO\nof\tO\ntacrolimus\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\nin\tO\norgan\tO\ntransplant\tO\npatients\tO\n.\tO\n\nOur\tO\nobjective\tO\nwas\tO\nto\tO\ninvestigate\tO\nbrain\tO\nMR\tO\nimaging\tO\nfindings\tO\nand\tO\nthe\tO\nutility\tO\nof\tO\ndiffusion\tO\n-\tO\nweighted\tO\n(\tO\nDW\tO\n)\tO\nimaging\tO\nin\tO\norgan\tO\ntransplant\tO\npatients\tO\nwho\tO\ndeveloped\tO\nneurologic\tO\nsymptoms\tO\nduring\tO\ntacrolimus\tB-Chemical\ntherapy\tO\n.\tO\n\nBrain\tO\nMR\tO\nstudies\tO\n,\tO\nincluding\tO\nDW\tO\nimaging\tO\n,\tO\nwere\tO\nprospectively\tO\nperformed\tO\nin\tO\n14\tO\norgan\tO\ntransplant\tO\npatients\tO\nreceiving\tO\ntacrolimus\tB-Chemical\nwho\tO\ndeveloped\tO\nneurologic\tB-Disease\ncomplications\tI-Disease\n.\tO\n\nIn\tO\neach\tO\npatient\tO\nwho\tO\nhad\tO\nabnormalities\tO\non\tO\nthe\tO\ninitial\tO\nMR\tO\nstudy\tO\n,\tO\na\tO\nfollow\tO\n-\tO\nup\tO\nMR\tO\nstudy\tO\nwas\tO\nperformed\tO\n1\tO\nmonth\tO\nlater\tO\n.\tO\n\nApparent\tO\ndiffusion\tO\ncoefficient\tO\n(\tO\nADC\tO\n)\tO\nvalues\tO\non\tO\nthe\tO\ninitial\tO\nMR\tO\nstudy\tO\nwere\tO\ncorrelated\tO\nwith\tO\nreversibility\tO\nof\tO\nthe\tO\nlesions\tO\n.\tO\n\nOf\tO\nthe\tO\n14\tO\npatients\tO\n,\tO\n5\tO\n(\tO\n35\tO\n.\tO\n7\tO\n%\tO\n)\tO\nhad\tO\nwhite\tB-Disease\nmatter\tI-Disease\nabnormalities\tI-Disease\n,\tO\n1\tO\n(\tO\n7\tO\n.\tO\n1\tO\n%\tO\n)\tO\nhad\tO\nputaminal\tB-Disease\nhemorrhage\tI-Disease\n,\tO\nand\tO\n8\tO\n(\tO\n57\tO\n.\tO\n1\tO\n%\tO\n)\tO\nhad\tO\nnormal\tO\nfindings\tO\non\tO\ninitial\tO\nMR\tO\nimages\tO\n.\tO\n\nAmong\tO\nthe\tO\n5\tO\npatients\tO\nwith\tO\nwhite\tB-Disease\nmatter\tI-Disease\nabnormalities\tI-Disease\n,\tO\n4\tO\npatients\tO\n(\tO\n80\tO\n.\tO\n0\tO\n%\tO\n)\tO\nshowed\tO\nhigher\tO\nthan\tO\nnormal\tO\nADC\tO\nvalues\tO\non\tO\ninitial\tO\nMR\tO\nimages\tO\n,\tO\nand\tO\nall\tO\nshowed\tO\ncomplete\tO\nresolution\tO\non\tO\nfollow\tO\n-\tO\nup\tO\nimages\tO\n.\tO\n\nThe\tO\nremaining\tO\n1\tO\npatient\tO\n(\tO\n20\tO\n.\tO\n0\tO\n%\tO\n)\tO\nshowed\tO\nlower\tO\nthan\tO\nnormal\tO\nADC\tO\nvalue\tO\nand\tO\nshowed\tO\nincomplete\tO\nresolution\tO\nwith\tO\ncortical\tB-Disease\nlaminar\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nDiffusion\tO\n-\tO\nweighted\tO\nimaging\tO\nmay\tO\nbe\tO\nuseful\tO\nin\tO\npredicting\tO\nthe\tO\noutcomes\tO\nof\tO\nthe\tO\nlesions\tO\nof\tO\ntacrolimus\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntransport\tO\nin\tO\nhumans\tO\nwith\tO\ncortisol\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n.\tO\n\nA\tO\ndeficient\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n-\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsystem\tO\nis\tO\nimplicated\tO\nin\tO\ncortisol\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n.\tO\n\nWe\tO\ninvestigate\tO\nwhether\tO\nabnormalities\tO\nin\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nuptake\tO\ncontribute\tO\nto\tO\nthis\tO\ndeficiency\tO\n.\tO\n\nEight\tO\nhealthy\tO\nmen\tO\nwere\tO\nrecruited\tO\n.\tO\n\nHydrocortisone\tB-Chemical\nacetate\tI-Chemical\n(\tO\n50\tO\nmg\tO\n)\tO\nwas\tO\ngiven\tO\norally\tO\nevery\tO\n6\tO\nhours\tO\nfor\tO\n24\tO\nhours\tO\nafter\tO\na\tO\n5\tO\n-\tO\nday\tO\nfixed\tO\n-\tO\nsalt\tO\ndiet\tO\n(\tO\n150\tO\nmmol\tO\n/\tO\nd\tO\n)\tO\n.\tO\n\nCrossover\tO\nstudies\tO\nwere\tO\nperformed\tO\n2\tO\nweeks\tO\napart\tO\n.\tO\n\nThirty\tO\nmilliliters\tO\nof\tO\nblood\tO\nwas\tO\nobtained\tO\nfor\tO\nisolation\tO\nof\tO\nperipheral\tO\nblood\tO\nmononuclear\tO\ncells\tO\nafter\tO\neach\tO\ntreatment\tO\nperiod\tO\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nuptake\tO\nwas\tO\nassessed\tO\nin\tO\nmononuclear\tO\ncells\tO\nincubated\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n(\tO\n1\tO\nto\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\n,\tO\nincorporating\tO\n100\tO\nnmol\tO\n/\tO\nL\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nfor\tO\na\tO\nperiod\tO\nof\tO\n5\tO\nminutes\tO\nat\tO\n37\tO\ndegrees\tO\nC\tO\n.\tO\n\nForearm\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nextraction\tO\nwas\tO\ncalculated\tO\nafter\tO\ninfusion\tO\nof\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ninto\tO\nthe\tO\nbrachial\tO\nartery\tO\nat\tO\na\tO\nrate\tO\nof\tO\n100\tO\nnCi\tO\n/\tO\nmin\tO\nfor\tO\n80\tO\nminutes\tO\n.\tO\n\nDeep\tO\nforearm\tO\nvenous\tO\nsamples\tO\nwere\tO\ncollected\tO\nfor\tO\ndetermination\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nextraction\tO\n.\tO\n\nPlasma\tO\ncortisol\tB-Chemical\nconcentrations\tO\nwere\tO\nsignificantly\tO\nraised\tO\nduring\tO\nthe\tO\nactive\tO\nphase\tO\n(\tO\n323\tO\n+\tO\n/\tO\n-\tO\n43\tO\nto\tO\n1082\tO\n+\tO\n/\tO\n-\tO\n245\tO\nmmol\tO\n/\tO\nL\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nSystolic\tO\nblood\tO\npressure\tO\nwas\tO\nelevated\tO\nby\tO\nan\tO\naverage\tO\nof\tO\n7\tO\nmm\tO\nHg\tO\n.\tO\n\nNeither\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntransport\tO\ninto\tO\nmononuclear\tO\ncells\tO\n(\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n26\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n6\tO\nvs\tO\n29\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\npmol\tO\n/\tO\n10\tO\n000\tO\ncells\tO\nper\tO\n5\tO\nminutes\tO\n,\tO\nrespectively\tO\n,\tO\nat\tO\nan\tO\nl\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nconcentration\tO\nof\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nnor\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nextraction\tO\nin\tO\nthe\tO\nforearm\tO\n(\tO\nat\tO\n80\tO\nminutes\tO\n,\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n1\tO\n868\tO\n904\tO\n+\tO\n/\tO\n-\tO\n434\tO\n962\tO\nvs\tO\n2\tO\n013\tO\n910\tO\n+\tO\n/\tO\n-\tO\n770\tO\n619\tO\ndisintegrations\tO\nper\tO\nminute\tO\n)\tO\nwas\tO\naffected\tO\nby\tO\ncortisol\tB-Chemical\ntreatment\tO\n;\tO\nie\tO\n,\tO\nthat\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nuptake\tO\nis\tO\nnot\tO\naffected\tO\nby\tO\nshort\tO\n-\tO\nterm\tO\ncortisol\tB-Chemical\ntreatment\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\ncortisol\tB-Chemical\n-\tO\ninduced\tO\nincreases\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nare\tO\nnot\tO\nassociated\tO\nwith\tO\nabnormalities\tO\nin\tO\nthe\tO\nl\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntransport\tO\nsystem\tO\n.\tO\n\nAmount\tO\nof\tO\nbleeding\tB-Disease\nand\tO\nhematoma\tB-Disease\nsize\tO\nin\tO\nthe\tO\ncollagenase\tO\n-\tO\ninduced\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\nrat\tO\nmodel\tO\n.\tO\n\nThe\tO\naggravated\tO\nrisk\tO\non\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n(\tO\nICH\tB-Disease\n)\tO\nwith\tO\ndrugs\tO\nused\tO\nfor\tO\nstroke\tB-Disease\npatients\tO\nshould\tO\nbe\tO\nestimated\tO\ncarefully\tO\n.\tO\n\nWe\tO\ntherefore\tO\nestablished\tO\nsensitive\tO\nquantification\tO\nmethods\tO\nand\tO\nprovided\tO\na\tO\nrat\tO\nICH\tB-Disease\nmodel\tO\nfor\tO\ndetection\tO\nof\tO\nICH\tB-Disease\ndeterioration\tO\n.\tO\n\nIn\tO\nICH\tB-Disease\nintrastriatally\tO\ninduced\tO\nby\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\n,\tO\n0\tO\n.\tO\n070\tO\n-\tO\nunit\tO\n,\tO\nand\tO\n0\tO\n.\tO\n350\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nthe\tO\namount\tO\nof\tO\nbleeding\tB-Disease\nwas\tO\nmeasured\tO\nusing\tO\na\tO\nhemoglobin\tO\nassay\tO\ndeveloped\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\nand\tO\nwas\tO\ncompared\tO\nwith\tO\nthe\tO\nmorphologically\tO\ndetermined\tO\nhematoma\tB-Disease\nvolume\tO\n.\tO\n\nThe\tO\nblood\tO\namounts\tO\nand\tO\nhematoma\tB-Disease\nvolumes\tO\nwere\tO\nsignificantly\tO\ncorrelated\tO\n,\tO\nand\tO\nthe\tO\nhematoma\tB-Disease\ninduced\tO\nby\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\nwas\tO\nadequate\tO\nto\tO\ndetect\tO\nICH\tB-Disease\ndeterioration\tO\n.\tO\n\nIn\tO\nICH\tB-Disease\ninduction\tO\nusing\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nheparin\tB-Chemical\nenhanced\tO\nthe\tO\nhematoma\tB-Disease\nvolume\tO\n3\tO\n.\tO\n4\tO\n-\tO\nfold\tO\nover\tO\nthat\tO\nseen\tO\nin\tO\ncontrol\tO\nICH\tB-Disease\nanimals\tO\nand\tO\nthe\tO\nbleeding\tB-Disease\n7\tO\n.\tO\n6\tO\n-\tO\nfold\tO\n.\tO\n\nData\tO\nsuggest\tO\nthat\tO\nthis\tO\nsensitive\tO\nhemoglobin\tO\nassay\tO\nis\tO\nuseful\tO\nfor\tO\nICH\tB-Disease\ndetection\tO\n,\tO\nand\tO\nthat\tO\na\tO\nmodel\tO\nwith\tO\na\tO\nsmall\tO\nICH\tB-Disease\ninduced\tO\nwith\tO\na\tO\nlow\tO\n-\tO\ndose\tO\ncollagenase\tO\nshould\tO\nbe\tO\nused\tO\nfor\tO\nevaluation\tO\nof\tO\ndrugs\tO\nthat\tO\nmay\tO\naffect\tO\nICH\tB-Disease\n.\tO\n\nEstradiol\tB-Chemical\nreduces\tO\nseizure\tB-Disease\n-\tO\ninduced\tO\nhippocampal\tB-Disease\ninjury\tI-Disease\nin\tO\novariectomized\tO\nfemale\tO\nbut\tO\nnot\tO\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nEstrogens\tO\nprotect\tO\novariectomized\tO\nrats\tO\nfrom\tO\nhippocampal\tB-Disease\ninjury\tI-Disease\ninduced\tO\nby\tO\nkainic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n(\tO\nSE\tB-Disease\n)\tO\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\neffects\tO\nof\tO\n17beta\tB-Chemical\n-\tI-Chemical\nestradiol\tI-Chemical\nin\tO\nadult\tO\nmale\tO\nand\tO\novariectomized\tO\nfemale\tO\nrats\tO\nsubjected\tO\nto\tO\nlithium\tB-Chemical\n-\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nSE\tB-Disease\n.\tO\n\nRats\tO\nreceived\tO\nsubcutaneous\tO\ninjections\tO\nof\tO\n17beta\tB-Chemical\n-\tI-Chemical\nestradiol\tI-Chemical\n(\tO\n2\tO\nmicrog\tO\n/\tO\nrat\tO\n)\tO\nor\tO\noil\tO\nonce\tO\ndaily\tO\nfor\tO\nfour\tO\nconsecutive\tO\ndays\tO\n.\tO\n\nSE\tB-Disease\nwas\tO\ninduced\tO\n20\tO\nh\tO\nfollowing\tO\nthe\tO\nsecond\tO\ninjection\tO\nand\tO\nterminated\tO\n3\tO\nh\tO\nlater\tO\n.\tO\n\nThe\tO\nextent\tO\nof\tO\nsilver\tB-Chemical\n-\tO\nstained\tO\nCA3\tO\nand\tO\nCA1\tO\nhippocampal\tO\nneurons\tO\nwas\tO\nevaluated\tO\n2\tO\ndays\tO\nafter\tO\nSE\tB-Disease\n.\tO\n\n17beta\tB-Chemical\n-\tI-Chemical\nEstradiol\tI-Chemical\ndid\tO\nnot\tO\nalter\tO\nthe\tO\nonset\tO\nof\tO\nfirst\tO\nclonus\tO\nin\tO\novariectomized\tO\nrats\tO\nbut\tO\naccelerated\tO\nit\tO\nin\tO\nmales\tO\n.\tO\n\n17beta\tB-Chemical\n-\tI-Chemical\nEstradiol\tI-Chemical\nreduced\tO\nthe\tO\nargyrophilic\tO\nneurons\tO\nin\tO\nthe\tO\nCA1\tO\nand\tO\nCA3\tO\n-\tO\nC\tO\nsectors\tO\nof\tO\novariectomized\tO\nrats\tO\n.\tO\n\nIn\tO\nmales\tO\n,\tO\nestradiol\tB-Chemical\nincreased\tO\nthe\tO\ntotal\tO\ndamage\tO\nscore\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nthe\tO\neffects\tO\nof\tO\nestradiol\tB-Chemical\non\tO\nseizure\tB-Disease\nthreshold\tO\nand\tO\ndamage\tO\nmay\tO\nbe\tO\naltered\tO\nby\tO\nsex\tO\n-\tO\nrelated\tO\ndifferences\tO\nin\tO\nthe\tO\nhormonal\tO\nenvironment\tO\n.\tO\n\nPseudoacromegaly\tB-Disease\ninduced\tO\nby\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nminoxidil\tB-Chemical\n.\tO\n\nAcromegaly\tB-Disease\nis\tO\nan\tO\nendocrine\tB-Disease\ndisorder\tI-Disease\ncaused\tO\nby\tO\nchronic\tO\nexcessive\tO\ngrowth\tO\nhormone\tO\nsecretion\tO\nfrom\tO\nthe\tO\nanterior\tO\npituitary\tO\ngland\tO\n.\tO\n\nSignificant\tO\ndisfiguring\tO\nchanges\tO\noccur\tO\nas\tO\na\tO\nresult\tO\nof\tO\nbone\tO\n,\tO\ncartilage\tO\n,\tO\nand\tO\nsoft\tO\ntissue\tO\nhypertrophy\tB-Disease\n,\tO\nincluding\tO\nthe\tO\nthickening\tO\nof\tO\nthe\tO\nskin\tO\n,\tO\ncoarsening\tO\nof\tO\nfacial\tO\nfeatures\tO\n,\tO\nand\tO\ncutis\tB-Disease\nverticis\tI-Disease\ngyrata\tI-Disease\n.\tO\n\nPseudoacromegaly\tB-Disease\n,\tO\non\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nis\tO\nthe\tO\npresence\tO\nof\tO\nsimilar\tO\nacromegaloid\tO\nfeatures\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nelevated\tO\ngrowth\tO\nhormone\tO\nor\tO\ninsulin\tO\n-\tO\nlike\tO\ngrowth\tO\nfactor\tO\nlevels\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\npatient\tO\nwith\tO\npseudoacromegaly\tB-Disease\nthat\tO\nresulted\tO\nfrom\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nminoxidil\tB-Chemical\nat\tO\nan\tO\nunusually\tO\nhigh\tO\ndose\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\npseudoacromegaly\tB-Disease\nas\tO\na\tO\nside\tO\neffect\tO\nof\tO\nminoxidil\tB-Chemical\nuse\tO\n.\tO\n\nCombined\tO\nandrogen\tO\nblockade\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nin\tO\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tO\nwithout\tO\nbone\tO\ninvolvement\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nonset\tO\nand\tO\nextent\tO\nof\tO\ncombined\tO\nandrogen\tO\nblockade\tO\n(\tO\nCAB\tO\n)\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nin\tO\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tO\nwithout\tO\nbone\tO\ninvolvement\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nForty\tO\n-\tO\ntwo\tO\npatients\tO\nwith\tO\nbiopsy\tO\n-\tO\nproven\tO\nprostatic\tB-Disease\nadenocarcinoma\tI-Disease\n[\tO\n26\tO\nwith\tO\nstage\tO\nC\tO\n(\tO\nT3N0M0\tO\n)\tO\nand\tO\n16\tO\nwith\tO\nstage\tO\nD1\tO\n(\tO\nT3N1M0\tO\n)\tO\n]\tO\nwere\tO\nincluded\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nAll\tO\npatients\tO\nreceived\tO\nCAB\tO\n[\tO\nleuprolide\tB-Chemical\nacetate\tI-Chemical\n(\tO\nLHRH\tB-Chemical\n-\tI-Chemical\nA\tI-Chemical\n)\tO\n3\tO\n.\tO\n75\tO\nmg\tO\n,\tO\nintramuscularly\tO\n,\tO\nevery\tO\n28\tO\ndays\tO\nplus\tO\n250\tO\nmg\tO\nflutamide\tB-Chemical\n,\tO\ntid\tO\n,\tO\nper\tO\nOs\tO\n]\tO\nand\tO\nwere\tO\nevaluated\tO\nfor\tO\nanemia\tB-Disease\nby\tO\nphysical\tO\nexamination\tO\nand\tO\nlaboratory\tO\ntests\tO\nat\tO\nbaseline\tO\nand\tO\n4\tO\nsubsequent\tO\nintervals\tO\n(\tO\n1\tO\n,\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n)\tO\n.\tO\n\nHb\tO\n,\tO\nPSA\tO\nand\tO\nTestosterone\tB-Chemical\nmeasurements\tO\nwere\tO\nrecorded\tO\n.\tO\n\nPatients\tO\nwith\tO\nstage\tO\nD2\tO\n-\tO\n3\tO\ndisease\tO\n,\tO\nabnormal\tO\nhemoglobin\tO\nlevel\tO\nor\tO\nrenal\tO\nand\tO\nliver\tO\nfunction\tO\ntests\tO\nthat\tO\nwere\tO\nhigher\tO\nthan\tO\nthe\tO\nupper\tO\nlimits\tO\nwere\tO\nexcluded\tO\nfrom\tO\nthe\tO\nstudy\tO\n.\tO\n\nThe\tO\nduration\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nsix\tO\nmonths\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nmean\tO\nhemoglobin\tO\n(\tO\nHb\tO\n)\tO\nlevels\tO\nwere\tO\nsignificantly\tO\ndeclined\tO\nin\tO\nall\tO\npatients\tO\nfrom\tO\nbaseline\tO\nof\tO\n14\tO\n.\tO\n2\tO\ng\tO\n/\tO\ndl\tO\nto\tO\n14\tO\n.\tO\n0\tO\ng\tO\n/\tO\ndl\tO\n,\tO\n13\tO\n.\tO\n5\tO\ng\tO\n/\tO\ndl\tO\n,\tO\n13\tO\n.\tO\n2\tO\ng\tO\n/\tO\ndl\tO\nand\tO\n12\tO\n.\tO\n7\tO\ng\tO\n/\tO\ndl\tO\nat\tO\n1\tO\n,\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n,\tO\nrespectively\tO\n.\tO\n\nSevere\tO\nand\tO\nclinically\tO\nevident\tO\nanemia\tB-Disease\nof\tO\nHb\tO\n<\tO\n11\tO\ng\tO\n/\tO\ndl\tO\nwith\tO\nclinical\tO\nsymptoms\tO\nwas\tO\ndetected\tO\nin\tO\n6\tO\npatients\tO\n(\tO\n14\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThis\tO\nCAB\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nwas\tO\nnormochromic\tO\nand\tO\nnormocytic\tO\n.\tO\n\nAt\tO\nsix\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n,\tO\npatients\tO\nwith\tO\nsevere\tO\nanemia\tB-Disease\nhad\tO\na\tO\nHb\tO\nmean\tO\nvalue\tO\nof\tO\n10\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\ng\tO\n/\tO\ndl\tO\n(\tO\nX\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n,\tO\nwhereas\tO\nthe\tO\nother\tO\npatients\tO\nhad\tO\nmild\tO\nanemia\tB-Disease\nwith\tO\nHb\tO\nmean\tO\nvalue\tO\nof\tO\n13\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n17\tO\n(\tO\nX\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nsevere\tO\nanemia\tB-Disease\nat\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\nwas\tO\npredictable\tO\nby\tO\nthe\tO\nreduction\tO\nof\tO\nHb\tO\nbaseline\tO\nvalue\tO\nof\tO\nmore\tO\nthan\tO\n2\tO\n.\tO\n5\tO\ng\tO\n/\tO\ndl\tO\nafter\tO\n3\tO\nmonths\tO\nof\tO\nCAB\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nsevere\tO\nCAB\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nin\tO\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tO\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nT\tO\nbaseline\tO\nvalues\tO\n(\tO\nT\tO\n<\tO\n3\tO\nng\tO\n/\tO\nml\tO\nversus\tO\nT\tO\n>\tO\nor\tO\n=\tO\n3\tO\nng\tO\n/\tO\nml\tO\n)\tO\n,\tO\nwith\tO\nage\tO\n(\tO\n<\tO\n76\tO\nyrs\tO\nversus\tO\n>\tO\nor\tO\n=\tO\n76\tO\nyrs\tO\n)\tO\n,\tO\nand\tO\nclinical\tO\nstage\tO\n(\tO\nstage\tO\nC\tO\nversus\tO\nstage\tO\nD1\tO\n)\tO\n.\tO\n\nSevere\tO\nand\tO\nclinically\tO\nevident\tO\nanemia\tB-Disease\nwas\tO\neasily\tO\ncorrected\tO\nby\tO\nsubcutaneous\tO\ninjections\tO\n(\tO\n3\tO\ntimes\tO\n/\tO\nweek\tO\nfor\tO\n1\tO\nmonth\tO\n)\tO\nof\tO\nrecombinant\tO\nerythropoietin\tO\n(\tO\nrHuEPO\tO\n-\tO\nbeta\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\ndata\tO\nsuggest\tO\nthat\tO\nrHuEPO\tO\n-\tO\nbeta\tO\ncorrectable\tO\nCAB\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\noccurs\tO\nin\tO\n14\tO\n.\tO\n3\tO\n%\tO\nof\tO\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tO\nafter\tO\n6\tO\nmonths\tO\nof\tO\ntherapy\tO\n.\tO\n\nDelirium\tB-Disease\nduring\tO\nclozapine\tB-Chemical\ntreatment\tO\n:\tO\nincidence\tO\nand\tO\nassociated\tO\nrisk\tO\nfactors\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIncidence\tO\nand\tO\nrisk\tO\nfactors\tO\nfor\tO\ndelirium\tB-Disease\nduring\tO\nclozapine\tB-Chemical\ntreatment\tO\nrequire\tO\nfurther\tO\nclarification\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nused\tO\ncomputerized\tO\npharmacy\tO\nrecords\tO\nto\tO\nidentify\tO\nall\tO\nadult\tO\npsychiatric\tB-Disease\ninpatients\tO\ntreated\tO\nwith\tO\nclozapine\tB-Chemical\n(\tO\n1995\tO\n-\tO\n96\tO\n)\tO\n,\tO\nreviewed\tO\ntheir\tO\nmedical\tO\nrecords\tO\nto\tO\nscore\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\ndelirium\tB-Disease\n,\tO\nand\tO\ntested\tO\nassociations\tO\nwith\tO\npotential\tO\nrisk\tO\nfactors\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSubjects\tO\n(\tO\nn\tO\n=\tO\n139\tO\n)\tO\nwere\tO\n72\tO\nwomen\tO\nand\tO\n67\tO\nmen\tO\n,\tO\naged\tO\n40\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n12\tO\n.\tO\n1\tO\nyears\tO\n,\tO\nhospitalized\tO\nfor\tO\n24\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n23\tO\n.\tO\n3\tO\ndays\tO\n,\tO\nand\tO\ngiven\tO\nclozapine\tB-Chemical\n,\tO\ngradually\tO\nincreased\tO\nto\tO\nan\tO\naverage\tO\ndaily\tO\ndose\tO\nof\tO\n282\tO\n+\tO\n/\tO\n-\tO\n203\tO\nmg\tO\n(\tO\n3\tO\n.\tO\n45\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n45\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nfor\tO\n18\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n16\tO\n.\tO\n4\tO\ndays\tO\n.\tO\n\nDelirium\tB-Disease\nwas\tO\ndiagnosed\tO\nin\tO\n14\tO\n(\tO\n10\tO\n.\tO\n1\tO\n%\tO\nincidence\tO\n,\tO\nor\tO\n1\tO\n.\tO\n48\tO\ncases\tO\n/\tO\nperson\tO\n-\tO\nyears\tO\nof\tO\nexposure\tO\n)\tO\n;\tO\n71\tO\n.\tO\n4\tO\n%\tO\nof\tO\ncases\tO\nwere\tO\nmoderate\tO\nor\tO\nsevere\tO\n.\tO\n\nAssociated\tO\nfactors\tO\nwere\tO\nco\tO\n-\tO\ntreatment\tO\nwith\tO\nother\tO\ncentrally\tO\nantimuscarinic\tO\nagents\tO\n,\tO\npoor\tO\nclinical\tO\noutcome\tO\n,\tO\nolder\tO\nage\tO\n,\tO\nand\tO\nlonger\tO\nhospitalization\tO\n(\tO\nby\tO\n17\tO\n.\tO\n5\tO\ndays\tO\n,\tO\nincreasing\tO\ncost\tO\n)\tO\n;\tO\nsex\tO\n,\tO\ndiagnosis\tO\nor\tO\nmedical\tO\nco\tO\n-\tO\nmorbidity\tO\n,\tO\nand\tO\ndaily\tO\nclozapine\tB-Chemical\ndose\tO\n,\tO\nwhich\tO\nfell\tO\nwith\tO\nage\tO\n,\tO\nwere\tO\nunrelated\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDelirium\tB-Disease\nwas\tO\nfound\tO\nin\tO\n10\tO\n%\tO\nof\tO\nclozapine\tB-Chemical\n-\tO\ntreated\tO\ninpatients\tO\n,\tO\nparticularly\tO\nin\tO\nolder\tO\npatients\tO\nexposed\tO\nto\tO\nother\tO\ncentral\tO\nanticholinergics\tO\n.\tO\n\nDelirium\tB-Disease\nwas\tO\ninconsistently\tO\nrecognized\tO\nclinically\tO\nin\tO\nmilder\tO\ncases\tO\nand\tO\nwas\tO\nassociated\tO\nwith\tO\nincreased\tO\nlength\tO\n-\tO\nof\tO\n-\tO\nstay\tO\nand\tO\nhigher\tO\ncosts\tO\n,\tO\nand\tO\ninferior\tO\nclinical\tO\noutcome\tO\n.\tO\n\nNeuroprotective\tO\naction\tO\nof\tO\nMPEP\tB-Chemical\n,\tO\na\tO\nselective\tO\nmGluR5\tO\nantagonist\tO\n,\tO\nin\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\ndopaminergic\tO\nneurotoxicity\tB-Disease\nis\tO\nassociated\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\ndopamine\tB-Chemical\noutflow\tO\nand\tO\ninhibition\tO\nof\tO\nhyperthermia\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\nrole\tO\nof\tO\nmetabotropic\tO\nglutamate\tB-Chemical\nreceptor\tO\n5\tO\n(\tO\nmGluR5\tO\n)\tO\nin\tO\nthe\tO\ntoxic\tO\naction\tO\nof\tO\nmethamphetamine\tB-Chemical\non\tO\ndopaminergic\tO\nneurones\tO\nin\tO\nrats\tO\n.\tO\n\nMethamphetamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\n,\tO\nadministered\tO\nfive\tO\ntimes\tO\n,\tO\nreduced\tO\nthe\tO\nlevels\tO\nof\tO\ndopamine\tB-Chemical\nand\tO\nits\tO\nmetabolites\tO\nin\tO\nstriatal\tO\ntissue\tO\nwhen\tO\nmeasured\tO\n72\tO\nh\tO\nafter\tO\nthe\tO\nlast\tO\ninjection\tO\n.\tO\n\nA\tO\nselective\tO\nantagonist\tO\nof\tO\nmGluR5\tO\n,\tO\n2\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\nphenylethynyl\tI-Chemical\n)\tI-Chemical\npyridine\tI-Chemical\n(\tO\nMPEP\tB-Chemical\n;\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\n,\tO\nwhen\tO\nadministered\tO\nfive\tO\ntimes\tO\nimmediately\tO\nbefore\tO\neach\tO\nmethamphetamine\tB-Chemical\ninjection\tO\nreversed\tO\nthe\tO\nabove\tO\n-\tO\nmentioned\tO\nmethamphetamine\tB-Chemical\neffects\tO\n.\tO\n\nA\tO\nsingle\tO\nMPEP\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\ninjection\tO\nreduced\tO\nthe\tO\nbasal\tO\nextracellular\tO\ndopamine\tB-Chemical\nlevel\tO\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nas\tO\nwell\tO\nas\tO\ndopamine\tB-Chemical\nrelease\tO\nstimulated\tO\neither\tO\nby\tO\nmethamphetamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\nor\tO\nby\tO\nintrastriatally\tO\nadministered\tO\nveratridine\tB-Chemical\n(\tO\n100\tO\nmicroM\tO\n)\tO\n.\tO\n\nMoreover\tO\n,\tO\nit\tO\ntransiently\tO\ndiminished\tO\nthe\tO\nmethamphetamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\n-\tO\ninduced\tO\nhyperthermia\tB-Disease\nand\tO\nreduced\tO\nbasal\tO\nbody\tO\ntemperature\tO\n.\tO\n\nMPEP\tB-Chemical\nadministered\tO\ninto\tO\nthe\tO\nstriatum\tO\nat\tO\nhigh\tO\nconcentrations\tO\n(\tO\n500\tO\nmicroM\tO\n)\tO\nincreased\tO\nextracellular\tO\ndopamine\tB-Chemical\nlevels\tO\n,\tO\nwhile\tO\nlower\tO\nconcentrations\tO\n(\tO\n50\tO\n-\tO\n100\tO\nmicroM\tO\n)\tO\nwere\tO\ndevoid\tO\nof\tO\nany\tO\neffect\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthis\tO\nstudy\tO\nsuggest\tO\nthat\tO\nthe\tO\nblockade\tO\nof\tO\nmGluR5\tO\nby\tO\nMPEP\tB-Chemical\nmay\tO\nprotect\tO\ndopaminergic\tO\nneurones\tO\nagainst\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\ntoxicity\tB-Disease\n.\tO\n\nNeuroprotection\tO\nrendered\tO\nby\tO\nMPEP\tB-Chemical\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nreduction\tO\nof\tO\nthe\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\ndopamine\tB-Chemical\nefflux\tO\nin\tO\nthe\tO\nstriatum\tO\ndue\tO\nto\tO\nthe\tO\nblockade\tO\nof\tO\nextrastriatal\tO\nmGluR5\tO\n,\tO\nand\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\nhyperthermia\tB-Disease\n.\tO\n\nProtective\tO\nefficacy\tO\nof\tO\nneuroactive\tO\nsteroids\tB-Chemical\nagainst\tO\ncocaine\tB-Chemical\nkindled\tO\n-\tO\nseizures\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nNeuroactive\tO\nsteroids\tB-Chemical\ndemonstrate\tO\npharmacological\tO\nactions\tO\nthat\tO\nhave\tO\nrelevance\tO\nfor\tO\na\tO\nhost\tO\nof\tO\nneurological\tB-Disease\nand\tI-Disease\npsychiatric\tI-Disease\ndisorders\tI-Disease\n.\tO\n\nThey\tO\noffer\tO\nprotection\tO\nagainst\tO\nseizures\tB-Disease\nin\tO\na\tO\nrange\tO\nof\tO\nmodels\tO\nand\tO\nseem\tO\nto\tO\ninhibit\tO\ncertain\tO\nstages\tO\nof\tO\ndrug\tB-Disease\ndependence\tI-Disease\nin\tO\npreclinical\tO\nassessments\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\ntwo\tO\nendogenous\tO\nand\tO\none\tO\nsynthetic\tO\nneuroactive\tO\nsteroid\tB-Chemical\nthat\tO\npositively\tO\nmodulate\tO\nthe\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n(\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\n)\tO\nreceptor\tO\nagainst\tO\nthe\tO\nincrease\tO\nin\tO\nsensitivity\tO\nto\tO\nthe\tO\nconvulsant\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\nengendered\tO\nby\tO\nrepeated\tO\ncocaine\tB-Chemical\nadministration\tO\n(\tO\nseizure\tB-Disease\nkindling\tO\n)\tO\n.\tO\n\nAllopregnanolone\tB-Chemical\n(\tO\n3alpha\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n5alpha\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n)\tO\n,\tO\npregnanolone\tB-Chemical\n(\tO\n3alpha\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n5beta\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n)\tO\nand\tO\nganaxolone\tB-Chemical\n(\tO\na\tO\nsynthetic\tO\nderivative\tO\nof\tO\nallopregnanolone\tB-Chemical\n3alpha\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n3beta\tI-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\n5alpha\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n)\tO\nwere\tO\ntested\tO\nfor\tO\ntheir\tO\nability\tO\nto\tO\nsuppress\tO\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\nkindled\tO\nseizures\tB-Disease\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nKindled\tO\nseizures\tB-Disease\nwere\tO\ninduced\tO\nby\tO\ndaily\tO\nadministration\tO\nof\tO\n60\tO\nmg\tO\n/\tO\nkg\tO\ncocaine\tB-Chemical\nfor\tO\n5\tO\ndays\tO\n.\tO\n\nAll\tO\nof\tO\nthese\tO\npositive\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nmodulators\tO\nsuppressed\tO\nthe\tO\nexpression\tO\nof\tO\nkindled\tO\nseizures\tB-Disease\n,\tO\nwhereas\tO\nonly\tO\nallopregnanolone\tB-Chemical\nand\tO\nganaxolone\tB-Chemical\ninhibited\tO\nthe\tO\ndevelopment\tO\nof\tO\nkindling\tO\n.\tO\n\nAllopregnanolone\tB-Chemical\nand\tO\npregnanolone\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nganaxolone\tB-Chemical\n,\tO\nalso\tO\nreduced\tO\ncumulative\tO\nlethality\tO\nassociated\tO\nwith\tO\nkindling\tO\n.\tO\n\nThese\tO\nfindings\tO\ndemonstrate\tO\nthat\tO\nsome\tO\nneuroactive\tO\nsteroids\tB-Chemical\nattenuate\tO\nconvulsant\tO\nand\tO\nsensitizing\tO\nproperties\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\nadd\tO\nto\tO\na\tO\ngrowing\tO\nliterature\tO\non\tO\ntheir\tO\npotential\tO\nuse\tO\nin\tO\nthe\tO\nmodulation\tO\nof\tO\neffects\tO\nof\tO\ndrugs\tO\nof\tO\nabuse\tO\n.\tO\n\nEffect\tO\nof\tO\nhumoral\tO\nmodulators\tO\nof\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nof\tO\nmice\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nhumoral\tO\nmodulators\tO\non\tO\nthe\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nof\tO\nmice\tO\nwas\tO\nstudied\tO\n.\tO\n\nThe\tO\nsubcutaneous\tO\nadministration\tO\nof\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nof\tO\nmorphine\tB-Chemical\n-\tO\nHC1\tO\nproduced\tO\na\tO\nmarked\tO\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nin\tO\nmice\tO\n.\tO\n\nThe\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nwas\tO\npotentiated\tO\nby\tO\nscopolamine\tB-Chemical\nand\tO\nattenuated\tO\nby\tO\nphysostigmine\tB-Chemical\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nboth\tO\nmethscopolamine\tB-Chemical\nand\tO\nneostigmine\tB-Chemical\n,\tO\nwhich\tO\ndo\tO\nnot\tO\npenetrate\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n,\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nhyperactivity\tB-Disease\nproduced\tO\nby\tO\nmorphine\tB-Chemical\n.\tO\n\nPretreatment\tO\nof\tO\nmice\tO\nwith\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyltyrosine\tI-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\none\tO\nhour\tO\n)\tO\n,\tO\nan\tO\ninhibitor\tO\nof\tO\ntyrosine\tB-Chemical\nhydroxylase\tO\n,\tO\nsignificantly\tO\ndecreased\tO\nthe\tO\nactivity\tO\n-\tO\nincreasing\tO\neffects\tO\nof\tO\nmorphine\tB-Chemical\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\npretreatment\tO\nwith\tO\np\tB-Chemical\n-\tI-Chemical\nchlorophenylalamine\tI-Chemical\n(\tO\n3\tO\nX\tO\n320\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\n24\tO\nhr\tO\n)\tO\n,\tO\na\tO\nserotonin\tB-Chemical\ndepletor\tO\n,\tO\ncaused\tO\nno\tO\nsignificant\tO\nchange\tO\nin\tO\nthe\tO\nhyperactivity\tB-Disease\n.\tO\n\nThe\tO\nstudy\tO\nsuggests\tO\nthat\tO\nthe\tO\nactivity\tO\n-\tO\nincreasing\tO\neffects\tO\nof\tO\nmorphine\tB-Chemical\nare\tO\nmediated\tO\nby\tO\nthe\tO\nrelease\tO\nof\tO\ncatecholamines\tB-Chemical\nfrom\tO\nadrenergic\tO\nneurons\tO\nin\tO\nthe\tO\nbrain\tO\n.\tO\n\nAnd\tO\nthe\tO\nresults\tO\nare\tO\nconsistent\tO\nwith\tO\nthe\tO\nhypothesis\tO\nthat\tO\nmorphine\tB-Chemical\nacts\tO\nby\tO\nretarding\tO\nthe\tO\nrelease\tO\nof\tO\nacetylcholine\tB-Chemical\nat\tO\nsome\tO\ncentral\tO\ncholinergic\tO\nsynapses\tO\n.\tO\n\nIt\tO\nis\tO\nalso\tO\nsuggested\tO\nfrom\tO\ncollected\tO\nevidence\tO\nthat\tO\nthe\tO\nactivity\tO\n-\tO\nincreasing\tO\neffects\tO\nof\tO\nmorphine\tB-Chemical\nin\tO\nmice\tO\nare\tO\nmediated\tO\nby\tO\nmechanisms\tO\ndifferent\tO\nfrom\tO\nthose\tO\nwhich\tO\nmediate\tO\nthe\tO\nactivity\tO\n-\tO\nincreasing\tO\neffects\tO\nof\tO\nmorphine\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nEffects\tO\nof\tO\nuninephrectomy\tO\nand\tO\nhigh\tO\nprotein\tO\nfeeding\tO\non\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nRats\tO\nwith\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\nwere\tO\nsubjected\tO\nto\tO\nhigh\tO\nprotein\tO\n(\tO\nHP\tO\n)\tO\nfeeding\tO\n,\tO\nuninephrectomy\tO\n(\tO\nNX\tO\n)\tO\nor\tO\na\tO\ncombination\tO\nof\tO\nthese\tO\n,\tO\nin\tO\nan\tO\nattempt\tO\nto\tO\ninduce\tO\nglomerular\tO\nhyperfiltration\tO\nand\tO\nfurther\tO\nprogression\tO\nof\tO\nrenal\tB-Disease\nfailure\tI-Disease\n.\tO\n\nNewborn\tO\nfemale\tO\nWistar\tO\nrats\tO\nwere\tO\nfed\tO\na\tO\nlithium\tB-Chemical\n-\tO\ncontaining\tO\ndiet\tO\n(\tO\n50\tO\nmmol\tO\n/\tO\nkg\tO\n)\tO\nfor\tO\n8\tO\nweeks\tO\nand\tO\nthen\tO\nrandomized\tO\nto\tO\nnormal\tO\ndiet\tO\n,\tO\nHP\tO\ndiet\tO\n(\tO\n40\tO\nvs\tO\n.\tO\n19\tO\n%\tO\n)\tO\n,\tO\nNX\tO\nor\tO\nHP\tO\n+\tO\nNX\tO\nfor\tO\nanother\tO\n8\tO\nweeks\tO\n.\tO\n\nCorresponding\tO\nnon\tO\n-\tO\nlithium\tB-Chemical\npretreated\tO\ngroups\tO\nwere\tO\ngenerated\tO\n.\tO\n\nWhen\tO\ncomparing\tO\nall\tO\nlithium\tB-Chemical\ntreated\tO\nversus\tO\nnon\tO\n-\tO\nlithium\tB-Chemical\n-\tO\ntreated\tO\ngroups\tO\n,\tO\nlithium\tB-Chemical\ncaused\tO\na\tO\nreduction\tO\nin\tO\nglomerular\tO\nfiltration\tO\nrate\tO\n(\tO\nGFR\tO\n)\tO\nwithout\tO\nsignificant\tO\nchanges\tO\nin\tO\neffective\tO\nrenal\tO\nplasma\tO\nflow\tO\n(\tO\nas\tO\ndetermined\tO\nby\tO\na\tO\nmarker\tO\nsecreted\tO\ninto\tO\nthe\tO\nproximal\tO\ntubules\tO\n)\tO\nor\tO\nlithium\tB-Chemical\nclearance\tO\n.\tO\n\nConsequently\tO\n,\tO\nlithium\tB-Chemical\npretreatment\tO\ncaused\tO\na\tO\nfall\tO\nin\tO\nfiltration\tO\nfraction\tO\nand\tO\nan\tO\nincrease\tO\nin\tO\nfractional\tO\nLi\tB-Chemical\nexcretion\tO\n.\tO\n\nLithium\tB-Chemical\nalso\tO\ncaused\tO\nproteinuria\tB-Disease\nand\tO\nsystolic\tO\nhypertension\tB-Disease\nin\tO\nabsence\tO\nof\tO\nglomerulosclerosis\tB-Disease\n.\tO\n\nHP\tO\nfailed\tO\nto\tO\naccentuante\tO\nprogression\tO\nof\tO\nrenal\tB-Disease\nfailure\tI-Disease\nand\tO\nin\tO\nfact\tO\ntended\tO\nto\tO\nincrease\tO\nGFR\tO\nand\tO\ndecrease\tO\nplasma\tO\ncreatinine\tB-Chemical\nlevels\tO\nin\tO\nlithium\tB-Chemical\npretreated\tO\nrats\tO\n.\tO\n\nNX\tO\ncaused\tO\nan\tO\nadditive\tO\ndeterioration\tO\nin\tO\nGFR\tO\nwhich\tO\n,\tO\nhowever\tO\n,\tO\nwas\tO\nameliorated\tO\nby\tO\nHP\tO\n.\tO\n\nNX\tO\n+\tO\nHP\tO\ncaused\tO\na\tO\nfurther\tO\nrise\tO\nin\tO\nblood\tO\npressure\tO\nin\tO\nLi\tB-Chemical\n-\tO\npretreated\tO\nrats\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nLi\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n,\tO\neven\tO\nwhen\tO\nthe\tO\nGFR\tO\nis\tO\nonly\tO\nmodestly\tO\nreduced\tO\n,\tO\nis\tO\nassociated\tO\nwith\tO\nproteinuria\tB-Disease\nand\tO\narterial\tO\nsystolic\tO\nhypertension\tB-Disease\n.\tO\n\nIn\tO\nthis\tO\nmodel\tO\nof\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nthe\tO\ndecline\tO\nin\tO\nGFR\tO\nis\tO\nnot\tO\naccompanied\tO\nby\tO\na\tO\ncorresponding\tO\nfall\tO\nin\tO\neffective\tO\nrenal\tO\nplasma\tO\nflow\tO\n,\tO\nwhich\tO\nmay\tO\nbe\tO\nthe\tO\nfunctional\tO\nexpression\tO\nof\tO\nthe\tO\nformation\tO\nof\tO\nnonfiltrating\tO\natubular\tO\nglomeruli\tO\n.\tO\n\nThe\tO\nfractional\tO\nreabsorption\tO\nof\tO\ntubular\tO\nfluid\tO\nby\tO\nthe\tO\nproximal\tO\ntubules\tO\nis\tO\nreduced\tO\n,\tO\nleaving\tO\nthe\tO\ndistal\tO\ndelivery\tO\nunchanged\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nTreatment\tO\nof\tO\nCrohn\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nwith\tO\nfusidic\tB-Chemical\nacid\tI-Chemical\n:\tO\nan\tO\nantibiotic\tO\nwith\tO\nimmunosuppressive\tO\nproperties\tO\nsimilar\tO\nto\tO\ncyclosporin\tB-Chemical\n.\tO\n\nFusidic\tO\nacid\tO\nis\tO\nan\tO\nantibiotic\tO\nwith\tO\nT\tO\n-\tO\ncell\tO\nspecific\tO\nimmunosuppressive\tO\neffects\tO\nsimilar\tO\nto\tO\nthose\tO\nof\tO\ncyclosporin\tB-Chemical\n.\tO\n\nBecause\tO\nof\tO\nthe\tO\nneed\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nnew\tO\ntreatments\tO\nfor\tO\nCrohn\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n,\tO\na\tO\npilot\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\nestimate\tO\nthe\tO\npharmacodynamics\tO\nand\tO\ntolerability\tO\nof\tO\nfusidic\tB-Chemical\nacid\tI-Chemical\ntreatment\tO\nin\tO\nchronic\tO\nactive\tO\n,\tO\ntherapy\tO\n-\tO\nresistant\tO\npatients\tO\n.\tO\n\nEight\tO\nCrohn\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\npatients\tO\nwere\tO\nincluded\tO\n.\tO\n\nFusidic\tB-Chemical\nacid\tI-Chemical\nwas\tO\nadministered\tO\norally\tO\nin\tO\na\tO\ndose\tO\nof\tO\n500\tO\nmg\tO\nt\tO\n.\tO\nd\tO\n.\tO\ns\tO\n.\tO\nand\tO\nthe\tO\ntreatment\tO\nwas\tO\nplanned\tO\nto\tO\nlast\tO\n8\tO\nweeks\tO\n.\tO\n\nThe\tO\ndisease\tO\nactivity\tO\nwas\tO\nprimarily\tO\nmeasured\tO\nby\tO\na\tO\nmodified\tO\nindividual\tO\ngrading\tO\nscore\tO\n.\tO\n\nFive\tO\nof\tO\n8\tO\npatients\tO\n(\tO\n63\tO\n%\tO\n)\tO\nimproved\tO\nduring\tO\nfusidic\tB-Chemical\nacid\tI-Chemical\ntreatment\tO\n:\tO\n3\tO\nat\tO\ntwo\tO\nweeks\tO\nand\tO\n2\tO\nafter\tO\nfour\tO\nweeks\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nserious\tO\nclinical\tO\nside\tO\neffects\tO\n,\tO\nbut\tO\ndose\tO\nreduction\tO\nwas\tO\nrequired\tO\nin\tO\ntwo\tO\npatients\tO\nbecause\tO\nof\tO\nnausea\tB-Disease\n.\tO\n\nBiochemically\tO\n,\tO\nan\tO\nincrease\tO\nin\tO\nalkaline\tO\nphosphatases\tO\nwas\tO\nnoted\tO\nin\tO\n5\tO\nof\tO\n8\tO\ncases\tO\n(\tO\n63\tO\n%\tO\n)\tO\n,\tO\nand\tO\nthe\tO\ngreatest\tO\nincreases\tO\nwere\tO\nseen\tO\nin\tO\nthose\tO\nwho\tO\nhad\tO\nelevated\tO\nlevels\tO\nprior\tO\nto\tO\ntreatment\tO\n.\tO\n\nAll\tO\nreversed\tO\nto\tO\npre\tO\n-\tO\ntreatment\tO\nlevels\tO\nafter\tO\ncessation\tO\nof\tO\ntreatment\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthis\tO\npilot\tO\nstudy\tO\nsuggest\tO\nthat\tO\nfusidic\tB-Chemical\nacid\tI-Chemical\nmay\tO\nbe\tO\nof\tO\nbenefit\tO\nin\tO\nselected\tO\nchronic\tO\nactive\tO\nCrohn\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\npatients\tO\nin\tO\nwhom\tO\nconventional\tO\ntreatment\tO\nis\tO\nineffective\tO\n.\tO\n\nBecause\tO\nthere\tO\nseems\tO\nto\tO\nexist\tO\na\tO\nscientific\tO\nrationale\tO\nfor\tO\nthe\tO\nuse\tO\nof\tO\nfusidic\tB-Chemical\nacid\tI-Chemical\nat\tO\nthe\tO\ncytokine\tO\nlevel\tO\nin\tO\ninflammatory\tB-Disease\nbowel\tI-Disease\ndisease\tI-Disease\n,\tO\nwe\tO\nsuggest\tO\nthat\tO\nthe\tO\nrole\tO\nof\tO\nthis\tO\ntreatment\tO\nshould\tO\nbe\tO\nfurther\tO\ninvestigated\tO\n.\tO\n\nChanges\tO\nin\tO\ndepressive\tB-Disease\nstatus\tO\nassociated\tO\nwith\tO\ntopical\tO\nbeta\tO\n-\tO\nblockers\tO\n.\tO\n\nDepression\tB-Disease\nand\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nside\tO\neffects\tO\nof\tO\ntopical\tO\nbeta\tO\n-\tO\nblockers\tO\n.\tO\n\nWe\tO\nperformed\tO\na\tO\npreliminary\tO\nstudy\tO\nin\tO\norder\tO\nto\tO\ndetermine\tO\nany\tO\ndifference\tO\nbetween\tO\na\tO\nnon\tO\nselective\tO\nbeta\tO\n-\tO\nblocker\tO\n(\tO\ntimolol\tB-Chemical\n)\tO\nand\tO\na\tO\nselective\tO\nbeta\tO\n-\tO\nblocker\tO\n(\tO\nbetaxolol\tB-Chemical\n)\tO\nregarding\tO\nCNS\tO\nside\tO\neffects\tO\n.\tO\n\nEight\tO\nglaucomatous\tB-Disease\npatients\tO\nchronically\tO\ntreated\tO\nwith\tO\ntimolol\tB-Chemical\n0\tO\n.\tO\n5\tO\n%\tO\n/\tO\n12h\tO\n,\tO\nsuffering\tO\nfrom\tO\ndepression\tB-Disease\ndiagnosed\tO\nthrough\tO\nDMS\tO\n-\tO\nIII\tO\n-\tO\nR\tO\ncriteria\tO\n,\tO\nwere\tO\nincluded\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nDuring\tO\nthe\tO\nsix\tO\n-\tO\nmonth\tO\nfollow\tO\nup\tO\n,\tO\ndepression\tB-Disease\nwas\tO\nquantified\tO\nthrough\tO\nthe\tO\nBeck\tO\nand\tO\nZung\tO\n-\tO\nConde\tO\nscales\tO\nevery\tO\ntwo\tO\nmonths\tO\n.\tO\n\nIn\tO\na\tO\ndouble\tO\nblind\tO\ncross\tO\n-\tO\nover\tO\nstudy\tO\nwith\tO\ncontrol\tO\ngroup\tO\n,\tO\nthe\tO\npatients\tO\nunder\tO\ntimolol\tB-Chemical\ntreatment\tO\npresented\tO\nhigher\tO\ndepression\tB-Disease\nvalues\tO\nmeasured\tO\nthrough\tO\nthe\tO\nBeck\tO\nand\tO\nthe\tO\nZung\tO\n-\tO\nConde\tO\nscales\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\nvs\tO\ncontrol\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nbetaxolol\tB-Chemical\ncould\tO\nbe\tO\nless\tO\nof\tO\na\tO\ndepression\tB-Disease\n-\tO\ninducer\tO\nthan\tO\ntimolol\tB-Chemical\nin\tO\npredisposed\tO\npatients\tO\n.\tO\n\nProtection\tO\nagainst\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\ntoward\tO\nstriatal\tO\ndopamine\tB-Chemical\nneurons\tO\nin\tO\nrodents\tO\nby\tO\nLY274614\tB-Chemical\n,\tO\nan\tO\nexcitatory\tO\namino\tB-Chemical\nacid\tI-Chemical\nantagonist\tO\n.\tO\n\nLY274614\tB-Chemical\n,\tO\n3SR\tB-Chemical\n,\tI-Chemical\n4aRS\tI-Chemical\n,\tI-Chemical\n6SR\tI-Chemical\n,\tI-Chemical\n8aRS\tI-Chemical\n-\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\nphosphonomethyl\tI-Chemical\n]\tI-Chemical\ndecahydr\tI-Chemical\noisoquinoline\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\ncarboxylic\tI-Chemical\nacid\tI-Chemical\n,\tO\nhas\tO\nbeen\tO\ndescribed\tO\nas\tO\na\tO\npotent\tO\nantagonist\tO\nof\tO\nthe\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nsubtype\tO\nof\tO\nglutamate\tB-Chemical\nreceptor\tO\n.\tO\n\nHere\tO\nits\tO\nability\tO\nto\tO\nantagonize\tO\nthe\tO\nprolonged\tO\ndepletion\tO\nof\tO\ndopamine\tB-Chemical\nin\tO\nthe\tO\nstriatum\tO\nby\tO\namphetamine\tB-Chemical\nin\tO\niprindole\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nis\tO\nreported\tO\n.\tO\n\nA\tO\nsingle\tO\n18\tO\n.\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\ndose\tO\nof\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\namphetamine\tB-Chemical\nhemisulfate\tO\n,\tO\ngiven\tO\nto\tO\nrats\tO\npretreated\tO\nwith\tO\niprindole\tB-Chemical\n,\tO\nresulted\tO\nin\tO\npersistent\tO\ndepletion\tO\nof\tO\ndopamine\tB-Chemical\nin\tO\nthe\tO\nstriatum\tO\n1\tO\nweek\tO\nlater\tO\n.\tO\n\nThis\tO\nprolonged\tO\ndepletion\tO\nof\tO\ndopamine\tB-Chemical\nin\tO\nthe\tO\nstriatum\tO\nwas\tO\nantagonized\tO\nby\tO\ndizocilpine\tB-Chemical\n(\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n,\tO\na\tO\nnon\tO\n-\tO\ncompetitive\tO\nantagonist\tO\nof\tO\nNMDA\tB-Chemical\nreceptors\tO\n)\tO\nor\tO\nby\tO\nLY274614\tB-Chemical\n(\tO\na\tO\ncompetitive\tO\nantagonist\tO\nof\tO\nNMDA\tB-Chemical\nreceptors\tO\n)\tO\n.\tO\n\nThe\tO\nprotective\tO\neffect\tO\nof\tO\nLY274614\tB-Chemical\nwas\tO\ndose\tO\n-\tO\ndependent\tO\n,\tO\nbeing\tO\nmaximum\tO\nat\tO\n10\tO\n-\tO\n40\tO\nmgkg\tO\n(\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nA\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\ndose\tO\nof\tO\nLY274614\tB-Chemical\nwas\tO\neffective\tO\nin\tO\nantagonizing\tO\nthe\tO\ndepletion\tO\nof\tO\ndopamine\tB-Chemical\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nwhen\tO\ngiven\tO\nas\tO\nlong\tO\nas\tO\n8\tO\nhr\tO\nprior\tO\nto\tO\namphetamine\tB-Chemical\nbut\tO\nnot\tO\nwhen\tO\ngiven\tO\n24\tO\nhr\tO\nprior\tO\nto\tO\namphetamine\tB-Chemical\n.\tO\n\nDepletion\tO\nof\tO\ndopamine\tB-Chemical\nin\tO\nthe\tO\nstriatum\tO\nwas\tO\nalso\tO\nantagonized\tO\nwhen\tO\nLY274614\tB-Chemical\nwas\tO\ngiven\tO\nafter\tO\nthe\tO\ninjection\tO\nof\tO\namphetamine\tB-Chemical\n;\tO\nLY274614\tB-Chemical\nprotected\tO\nwhen\tO\ngiven\tO\nup\tO\nto\tO\n4\tO\nhr\tO\nafter\tO\nbut\tO\nnot\tO\nwhen\tO\ngiven\tO\n8\tO\nor\tO\n24\tO\nhr\tO\nafter\tO\namphetamine\tB-Chemical\n.\tO\n\nThe\tO\nprolonged\tO\ndepletion\tO\nof\tO\ndopamine\tB-Chemical\nin\tO\nthe\tO\nstriatum\tO\nin\tO\nmice\tO\n,\tO\ngiven\tO\nmultiple\tO\ninjections\tO\nof\tO\nmethamphetamine\tB-Chemical\n,\tO\nwas\tO\nalso\tO\nantagonized\tO\ndose\tO\n-\tO\ndependently\tO\nand\tO\ncompletely\tO\nby\tO\nLY274614\tB-Chemical\n.\tO\n\nThe\tO\ndata\tO\nstrengthen\tO\nthe\tO\nevidence\tO\nthat\tO\nthe\tO\nneurotoxic\tB-Disease\neffect\tO\nof\tO\namphetamine\tB-Chemical\nand\tO\nrelated\tO\ncompounds\tO\ntoward\tO\nnigrostriatal\tO\ndopamine\tB-Chemical\nneurons\tO\ninvolves\tO\nNMDA\tB-Chemical\nreceptors\tO\nand\tO\nthat\tO\nLY274614\tB-Chemical\nis\tO\nan\tO\nNMDA\tB-Chemical\nreceptor\tO\nantagonist\tO\nwith\tO\nlong\tO\n-\tO\nlasting\tO\nin\tO\nvivo\tO\neffects\tO\nin\tO\nrats\tO\n.\tO\n\nKetoconazole\tB-Chemical\n-\tO\ninduced\tO\nneurologic\tB-Disease\nsequelae\tI-Disease\n.\tO\n\nA\tO\n77\tO\n-\tO\ny\tO\n-\tO\nold\tO\npatient\tO\ndeveloped\tO\nweakness\tB-Disease\nof\tI-Disease\nextremities\tI-Disease\n,\tO\nlegs\tB-Disease\nparalysis\tI-Disease\n,\tO\ndysarthria\tB-Disease\nand\tO\ntremor\tB-Disease\n1\tO\nh\tO\nafter\tO\ningestion\tO\nof\tO\n200\tO\nmg\tO\nketoconazole\tB-Chemical\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nhis\tO\nlife\tO\n.\tO\n\nAll\tO\ncomplaints\tO\nfaded\tO\naway\tO\nwithin\tO\n24\tO\nh\tO\n.\tO\n\nFew\tO\ndays\tO\nlater\tO\n,\tO\nthe\tO\npatient\tO\nused\tO\nanother\tO\n200\tO\nmg\tO\nketoconazole\tB-Chemical\ntablet\tO\n,\tO\nand\tO\nwithin\tO\nan\tO\nhour\tO\nexperienced\tO\na\tO\nsimilar\tO\nclinical\tO\npicture\tO\n,\tO\nwhich\tO\nresolved\tO\nagain\tO\nspontaneously\tO\nwithin\tO\nhours\tO\n.\tO\n\nLaboratory\tO\nevaluations\tO\n,\tO\nincluding\tO\nhead\tO\nCT\tO\nscan\tO\n,\tO\nwere\tO\nnormal\tO\n.\tO\n\nThis\tO\ncase\tO\nillustrates\tO\nthe\tO\nneed\tO\nfor\tO\nclose\tO\nvigilance\tO\nin\tO\nadverse\tB-Disease\ndrug\tI-Disease\nreactions\tI-Disease\n,\tO\nparticularly\tO\nin\tO\nthe\tO\nelderly\tO\n.\tO\n\nDevelopment\tO\nof\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nin\tO\nparkinsonian\tB-Disease\nmonkeys\tO\nmay\tO\ndepend\tO\nupon\tO\nrate\tO\nof\tO\nsymptom\tO\nonset\tO\nand\tO\n/\tO\nor\tO\nduration\tO\nof\tO\nsymptoms\tO\n.\tO\n\nLevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n(\tO\nLIDs\tB-Disease\n)\tO\npresent\tO\na\tO\nmajor\tO\nproblem\tO\nfor\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nmanagement\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\npatients\tO\n.\tO\n\nDue\tO\nto\tO\nthe\tO\ninterdependence\tO\nof\tO\nrisk\tO\nfactors\tO\nin\tO\nclinical\tO\npopulations\tO\n,\tO\nit\tO\nis\tO\ndifficult\tO\nto\tO\nindependently\tO\nexamine\tO\nfactors\tO\nthat\tO\nmay\tO\ninfluence\tO\nthe\tO\ndevelopment\tO\nof\tO\nLIDs\tB-Disease\n.\tO\n\nUsing\tO\nmacaque\tO\nmonkeys\tO\nwith\tO\ndifferent\tO\ntypes\tO\nof\tO\nMPTP\tB-Chemical\n-\tO\ninduced\tO\nparkinsonism\tB-Disease\n,\tO\nthe\tO\ncurrent\tO\nstudy\tO\nevaluated\tO\nthe\tO\ndegree\tO\nto\tO\nwhich\tO\nrate\tO\nof\tO\nsymptom\tO\nprogression\tO\n,\tO\nsymptom\tO\nseverity\tO\n,\tO\nand\tO\nresponse\tO\nto\tO\nand\tO\nduration\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nLIDs\tB-Disease\n.\tO\n\nMonkeys\tO\nwith\tO\nacute\tO\n(\tO\nshort\tO\n-\tO\nterm\tO\n)\tO\nMPTP\tB-Chemical\nexposure\tO\n,\tO\nrapid\tO\nsymptom\tO\nonset\tO\nand\tO\nshort\tO\nsymptom\tO\nduration\tO\nprior\tO\nto\tO\ninitiation\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\ndeveloped\tO\ndyskinesia\tB-Disease\nbetween\tO\n11\tO\nand\tO\n24\tO\ndays\tO\nof\tO\ndaily\tO\nlevodopa\tB-Chemical\nadministration\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nmonkeys\tO\nwith\tO\nlong\tO\n-\tO\nterm\tO\nMPTP\tB-Chemical\nexposure\tO\n,\tO\nslow\tO\nsymptom\tO\nprogression\tO\nand\tO\n/\tO\nor\tO\nlong\tO\nsymptom\tO\nduration\tO\nprior\tO\nto\tO\ninitiation\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\nwere\tO\nmore\tO\nresistant\tO\nto\tO\ndeveloping\tO\nLIDs\tB-Disease\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\ndyskinesia\tB-Disease\ndeveloped\tO\nno\tO\nsooner\tO\nthan\tO\n146\tO\ndays\tO\nof\tO\nchronic\tO\nlevodopa\tB-Chemical\nadministration\tO\n)\tO\n.\tO\n\nAll\tO\nanimals\tO\nwere\tO\nsimilarly\tO\nsymptomatic\tO\nat\tO\nthe\tO\nstart\tO\nof\tO\nlevodopa\tB-Chemical\ntreatment\tO\nand\tO\nhad\tO\nsimilar\tO\ntherapeutic\tO\nresponses\tO\nto\tO\nthe\tO\ndrug\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\ndistinct\tO\ndifferences\tO\nin\tO\nthe\tO\npropensity\tO\nto\tO\ndevelop\tO\nLIDs\tB-Disease\nin\tO\nmonkeys\tO\nwith\tO\ndifferent\tO\nrates\tO\nof\tO\nsymptom\tO\nprogression\tO\nor\tO\nsymptom\tO\ndurations\tO\nprior\tO\nto\tO\nlevodopa\tB-Chemical\nand\tO\ndemonstrate\tO\nthe\tO\nvalue\tO\nof\tO\nthese\tO\nmodels\tO\nfor\tO\nfurther\tO\nstudying\tO\nthe\tO\npathophysiology\tO\nof\tO\nLIDs\tB-Disease\n.\tO\n\nA\tO\ndiet\tO\npromoting\tO\nsugar\tB-Disease\ndependency\tI-Disease\ncauses\tO\nbehavioral\tB-Disease\ncross\tI-Disease\n-\tI-Disease\nsensitization\tI-Disease\nto\tO\na\tO\nlow\tO\ndose\tO\nof\tO\namphetamine\tB-Chemical\n.\tO\n\nPrevious\tO\nresearch\tO\nin\tO\nthis\tO\nlaboratory\tO\nhas\tO\nshown\tO\nthat\tO\na\tO\ndiet\tO\nof\tO\nintermittent\tO\nexcessive\tO\nsugar\tO\nconsumption\tO\nproduces\tO\na\tO\nstate\tO\nwith\tO\nneurochemical\tO\nand\tO\nbehavioral\tO\nsimilarities\tO\nto\tO\ndrug\tB-Disease\ndependency\tI-Disease\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nexamined\tO\nwhether\tO\nfemale\tO\nrats\tO\non\tO\nvarious\tO\nregimens\tO\nof\tO\nsugar\tO\naccess\tO\nwould\tO\nshow\tO\nbehavioral\tB-Disease\ncross\tI-Disease\n-\tI-Disease\nsensitization\tI-Disease\nto\tO\na\tO\nlow\tO\ndose\tO\nof\tO\namphetamine\tB-Chemical\n.\tO\n\nAfter\tO\na\tO\n30\tO\n-\tO\nmin\tO\nbaseline\tO\nmeasure\tO\nof\tO\nlocomotor\tO\nactivity\tO\n(\tO\nday\tO\n0\tO\n)\tO\n,\tO\nanimals\tO\nwere\tO\nmaintained\tO\non\tO\na\tO\ncyclic\tO\ndiet\tO\nof\tO\n12\tO\n-\tO\nh\tO\ndeprivation\tO\nfollowed\tO\nby\tO\n12\tO\n-\tO\nh\tO\naccess\tO\nto\tO\n10\tO\n%\tO\nsucrose\tB-Chemical\nsolution\tO\nand\tO\nchow\tO\npellets\tO\n(\tO\n12\tO\nh\tO\naccess\tO\nstarting\tO\n4\tO\nh\tO\nafter\tO\nonset\tO\nof\tO\nthe\tO\ndark\tO\nperiod\tO\n)\tO\nfor\tO\n21\tO\ndays\tO\n.\tO\n\nLocomotor\tO\nactivity\tO\nwas\tO\nmeasured\tO\nagain\tO\nfor\tO\n30\tO\nmin\tO\nat\tO\nthe\tO\nbeginning\tO\nof\tO\ndays\tO\n1\tO\nand\tO\n21\tO\nof\tO\nsugar\tO\naccess\tO\n.\tO\n\nBeginning\tO\non\tO\nday\tO\n22\tO\n,\tO\nall\tO\nrats\tO\nwere\tO\nmaintained\tO\non\tO\nad\tO\nlibitum\tO\nchow\tO\n.\tO\n\nNine\tO\ndays\tO\nlater\tO\nlocomotor\tO\nactivity\tO\nwas\tO\nmeasured\tO\nin\tO\nresponse\tO\nto\tO\na\tO\nsingle\tO\nlow\tO\ndose\tO\nof\tO\namphetamine\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nThe\tO\nanimals\tO\nthat\tO\nhad\tO\nexperienced\tO\ncyclic\tO\nsucrose\tB-Chemical\nand\tO\nchow\tO\nwere\tO\nhyperactive\tB-Disease\nin\tO\nresponse\tO\nto\tO\namphetamine\tB-Chemical\ncompared\tO\nwith\tO\nfour\tO\ncontrol\tO\ngroups\tO\n(\tO\nad\tO\nlibitum\tO\n10\tO\n%\tO\nsucrose\tB-Chemical\nand\tO\nchow\tO\nfollowed\tO\nby\tO\namphetamine\tB-Chemical\ninjection\tO\n,\tO\ncyclic\tO\nchow\tO\nfollowed\tO\nby\tO\namphetamine\tB-Chemical\ninjection\tO\n,\tO\nad\tO\nlibitum\tO\nchow\tO\nwith\tO\namphetamine\tB-Chemical\n,\tO\nor\tO\ncyclic\tO\n10\tO\n%\tO\nsucrose\tB-Chemical\nand\tO\nchow\tO\nwith\tO\na\tO\nsaline\tO\ninjection\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\na\tO\ndiet\tO\ncomprised\tO\nof\tO\nalternating\tO\ndeprivation\tO\nand\tO\naccess\tO\nto\tO\na\tO\nsugar\tO\nsolution\tO\nand\tO\nchow\tO\nproduces\tO\nbingeing\tO\non\tO\nsugar\tO\nthat\tO\nleads\tO\nto\tO\na\tO\nlong\tO\nlasting\tO\nstate\tO\nof\tO\nincreased\tO\nsensitivity\tO\nto\tO\namphetamine\tB-Chemical\n,\tO\npossibly\tO\ndue\tO\nto\tO\na\tO\nlasting\tO\nalteration\tO\nin\tO\nthe\tO\ndopamine\tB-Chemical\nsystem\tO\n.\tO\n\nReversible\tO\ndilated\tB-Disease\ncardiomyopathy\tI-Disease\nrelated\tO\nto\tO\namphotericin\tB-Chemical\nB\tI-Chemical\ntherapy\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\npatient\tO\nwho\tO\ndeveloped\tO\ndilated\tB-Disease\ncardiomyopathy\tI-Disease\nand\tO\nclinical\tO\ncongestive\tO\nheart\tB-Disease\nfailure\tI-Disease\nafter\tO\n2\tO\nmonths\tO\nof\tO\ntherapy\tO\nwith\tO\namphotericin\tB-Chemical\nB\tI-Chemical\n(\tO\nAmB\tB-Chemical\n)\tO\nfor\tO\ndisseminated\tO\ncoccidioidomycosis\tB-Disease\n.\tO\n\nHis\tO\nechocardiographic\tO\nabnormalities\tO\nand\tO\nheart\tB-Disease\nfailure\tI-Disease\nresolved\tO\nafter\tO\nposaconazole\tB-Chemical\nwas\tO\nsubstituted\tO\nfor\tO\nAmB\tB-Chemical\n.\tO\n\nIt\tO\nis\tO\nimportant\tO\nto\tO\nrecognize\tO\nthe\tO\nrare\tO\nand\tO\npotentially\tO\nreversible\tO\ntoxicity\tB-Disease\nof\tO\nAmB\tB-Chemical\n.\tO\n\nNO\tB-Chemical\n-\tO\ninduced\tO\nmigraine\tB-Disease\nattack\tO\n:\tO\nstrong\tO\nincrease\tO\nin\tO\nplasma\tO\ncalcitonin\tB-Chemical\ngene\tI-Chemical\n-\tI-Chemical\nrelated\tI-Chemical\npeptide\tI-Chemical\n(\tO\nCGRP\tB-Chemical\n)\tO\nconcentration\tO\nand\tO\nnegative\tO\ncorrelation\tO\nwith\tO\nplatelet\tO\nserotonin\tB-Chemical\nrelease\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nchanges\tO\nin\tO\nthe\tO\nplasma\tO\ncalcitonin\tB-Chemical\ngene\tI-Chemical\n-\tI-Chemical\nrelated\tI-Chemical\npeptide\tI-Chemical\n(\tO\nCGRP\tB-Chemical\n)\tO\nconcentration\tO\nand\tO\nplatelet\tO\nserotonin\tB-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytriptamine\tI-Chemical\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n)\tO\ncontent\tO\nduring\tO\nthe\tO\nimmediate\tO\nheadache\tB-Disease\nand\tO\nthe\tO\ndelayed\tO\ngenuine\tO\nmigraine\tB-Disease\nattack\tO\nprovoked\tO\nby\tO\nnitroglycerin\tB-Chemical\n.\tO\n\nFifteen\tO\nfemale\tO\nmigraineurs\tB-Disease\n(\tI-Disease\nwithout\tI-Disease\naura\tI-Disease\n)\tI-Disease\nand\tO\neight\tO\ncontrols\tO\nparticipated\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nSublingual\tO\nnitroglycerin\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n)\tO\nwas\tO\nadministered\tO\n.\tO\n\nBlood\tO\nwas\tO\ncollected\tO\nfrom\tO\nthe\tO\nantecubital\tO\nvein\tO\nfour\tO\ntimes\tO\n:\tO\n60\tO\nmin\tO\nbefore\tO\nand\tO\nafter\tO\nthe\tO\nnitroglycerin\tB-Chemical\napplication\tO\n,\tO\nand\tO\n60\tO\nand\tO\n120\tO\nmin\tO\nafter\tO\nthe\tO\nbeginning\tO\nof\tO\nthe\tO\nmigraine\tB-Disease\nattack\tO\n(\tO\nmean\tO\n344\tO\nand\tO\n404\tO\nmin\tO\n;\tO\n12\tO\nsubjects\tO\n)\tO\n.\tO\n\nIn\tO\nthose\tO\nsubjects\tO\nwho\tO\nhad\tO\nno\tO\nmigraine\tB-Disease\nattack\tO\n(\tO\n11\tO\nsubjects\tO\n)\tO\na\tO\nsimilar\tO\ntime\tO\nschedule\tO\nwas\tO\nused\tO\n.\tO\n\nPlasma\tO\nCGRP\tB-Chemical\nconcentration\tO\nincreased\tO\nsignificantly\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nduring\tO\nthe\tO\nmigraine\tB-Disease\nattack\tO\nand\tO\nreturned\tO\nto\tO\nbaseline\tO\nafter\tO\nthe\tO\ncessation\tO\nof\tO\nthe\tO\nmigraine\tB-Disease\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nboth\tO\nchange\tO\nand\tO\npeak\tO\n,\tO\nshowed\tO\nsignificant\tO\npositive\tO\ncorrelations\tO\nwith\tO\nmigraine\tB-Disease\nheadache\tB-Disease\nintensity\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nplasma\tO\nCGRP\tB-Chemical\nconcentrations\tO\nfailed\tO\nto\tO\nchange\tO\nduring\tO\nimmediate\tO\nheadache\tB-Disease\nand\tO\nin\tO\nthe\tO\nsubjects\tO\nwith\tO\nno\tO\nmigraine\tB-Disease\nattack\tO\n.\tO\n\nBasal\tO\nCGRP\tB-Chemical\nconcentration\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nand\tO\nplatelet\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\ncontent\tO\ntended\tO\nto\tO\nbe\tO\nlower\tO\nin\tO\nsubjects\tO\nwho\tO\nexperienced\tO\na\tO\nmigraine\tB-Disease\nattack\tO\n.\tO\n\nPlatelet\tO\nserotonin\tB-Chemical\ncontent\tO\ndecreased\tO\nsignificantly\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nafter\tO\nnitroglycerin\tB-Chemical\nin\tO\nsubjects\tO\nwith\tO\nno\tO\nmigraine\tB-Disease\nattack\tO\nbut\tO\nno\tO\nconsistent\tO\nchange\tO\nwas\tO\nobserved\tO\nin\tO\npatients\tO\nwith\tO\nmigraine\tB-Disease\nattack\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\nfact\tO\nthat\tO\nplasma\tO\nCGRP\tB-Chemical\nconcentration\tO\ncorrelates\tO\nwith\tO\nthe\tO\ntiming\tO\nand\tO\nseverity\tO\nof\tO\na\tO\nmigraine\tB-Disease\nheadache\tB-Disease\nsuggests\tO\na\tO\ndirect\tO\nrelationship\tO\nbetween\tO\nCGRP\tB-Chemical\nand\tO\nmigraine\tB-Disease\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nserotonin\tB-Chemical\nrelease\tO\nfrom\tO\nplatelets\tO\ndoes\tO\nnot\tO\nprovoke\tO\nmigraine\tB-Disease\n,\tO\nit\tO\nmay\tO\neven\tO\ncounteract\tO\nthe\tO\nheadache\tB-Disease\nand\tO\nthe\tO\nconcomitant\tO\nCGRP\tB-Chemical\nrelease\tO\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nHyperbaric\tO\noxygen\tB-Chemical\ntherapy\tO\nfor\tO\ncontrol\tO\nof\tO\nintractable\tO\ncyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nintractable\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\ndue\tO\nto\tO\ncyclophosphamide\tB-Chemical\ntherapy\tO\nfor\tO\nWegener\tB-Disease\n'\tI-Disease\ns\tI-Disease\ngranulomatosis\tI-Disease\n.\tO\n\nConservative\tO\ntreatment\tO\n,\tO\nincluding\tO\nbladder\tO\nirrigation\tO\nwith\tO\nphysiological\tO\nsaline\tO\nand\tO\ninstillation\tO\nof\tO\nprostaglandin\tB-Chemical\nF2\tI-Chemical\nalpha\tI-Chemical\n,\tO\nfailed\tO\nto\tO\ntotally\tO\ncontrol\tO\nhemorrhage\tB-Disease\n.\tO\n\nWe\tO\nthen\tO\nused\tO\nhyperbaric\tO\noxygen\tB-Chemical\nat\tO\nan\tO\nabsolute\tO\npressure\tO\nof\tO\n2\tO\natm\tO\n,\tO\n5\tO\ndays\tO\na\tO\nweek\tO\nfor\tO\n8\tO\nconsecutive\tO\nweeks\tO\n.\tO\n\nThe\tO\nbleeding\tB-Disease\nceased\tO\ncompletely\tO\nby\tO\nthe\tO\nend\tO\nof\tO\ntreatment\tO\nand\tO\nthe\tO\npatient\tO\nremained\tO\nfree\tO\nof\tO\nhematuria\tB-Disease\nthereafter\tO\n.\tO\n\nNo\tO\nside\tO\neffect\tO\nwas\tO\nnoted\tO\nduring\tO\nthe\tO\ncourse\tO\nof\tO\ntherapy\tO\n.\tO\n\nIn\tO\nfuture\tO\n,\tO\nthis\tO\nform\tO\nof\tO\ntherapy\tO\ncan\tO\noffer\tO\na\tO\nsafe\tO\nalternative\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\ncyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nAcute\tB-Disease\npsychosis\tI-Disease\ndue\tO\nto\tO\ntreatment\tO\nwith\tO\nphenytoin\tB-Chemical\nin\tO\na\tO\nnonepileptic\tO\npatient\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\npsychosis\tB-Disease\nrelated\tO\nto\tO\nantiepileptic\tO\ndrug\tO\ntreatment\tO\nis\tO\nusually\tO\nattributed\tO\nto\tO\nthe\tO\ninteraction\tO\nbetween\tO\nthe\tO\nepileptic\tB-Disease\nbrain\tO\nsubstratum\tO\nand\tO\nthe\tO\nantiepileptic\tO\ndrugs\tO\n.\tO\n\nThe\tO\ncase\tO\nof\tO\na\tO\nnonepileptic\tO\npatient\tO\nwho\tO\ndeveloped\tO\npsychosis\tB-Disease\nfollowing\tO\nphenytoin\tB-Chemical\ntreatment\tO\nfor\tO\ntrigeminal\tB-Disease\nneuralgia\tI-Disease\nis\tO\ndescribed\tO\n.\tO\n\nThis\tO\ncase\tO\nsuggests\tO\nthat\tO\nthe\tO\npsychotic\tB-Disease\nsymptoms\tI-Disease\nthat\tO\noccur\tO\nfollowing\tO\nphenytoin\tB-Chemical\ntreatment\tO\nin\tO\nsome\tO\nepileptic\tB-Disease\npatients\tO\nmay\tO\nbe\tO\nthe\tO\ndirect\tO\nresult\tO\nof\tO\nmedication\tO\n,\tO\nunrelated\tO\nto\tO\nseizures\tB-Disease\n.\tO\n\nRisks\tO\nof\tO\nthe\tO\nconsumption\tO\nof\tO\nbeverages\tO\ncontaining\tO\nquinine\tB-Chemical\n.\tO\n\nAlthough\tO\nthe\tO\nUnited\tO\nStates\tO\nFood\tO\nand\tO\nDrug\tO\nAdministration\tO\nbanned\tO\nits\tO\nuse\tO\nfor\tO\nnocturnal\tB-Disease\nleg\tI-Disease\ncramps\tI-Disease\ndue\tO\nto\tO\nlack\tO\nof\tO\nsafety\tO\nand\tO\nefficacy\tO\n,\tO\nquinine\tB-Chemical\nis\tO\nwidely\tO\navailable\tO\nin\tO\nbeverages\tO\nincluding\tO\ntonic\tO\nwater\tO\nand\tO\nbitter\tO\nlemon\tO\n.\tO\n\nNumerous\tO\nanecdotal\tO\nreports\tO\nsuggest\tO\nthat\tO\nproducts\tO\ncontaining\tO\nquinine\tB-Chemical\nmay\tO\nproduce\tO\nneurological\tB-Disease\ncomplications\tI-Disease\n,\tO\nincluding\tO\nconfusion\tB-Disease\n,\tO\naltered\tO\nmental\tO\nstatus\tO\n,\tO\nseizures\tB-Disease\n,\tO\nand\tO\ncoma\tB-Disease\n,\tO\nparticularly\tO\nin\tO\nolder\tO\nwomen\tO\n.\tO\n\nPsychologists\tO\nneed\tO\nto\tO\ninquire\tO\nabout\tO\nconsumption\tO\nof\tO\nquinine\tB-Chemical\n-\tO\ncontaining\tO\nbeverages\tO\nas\tO\npart\tO\nof\tO\nan\tO\nevaluation\tO\nprocess\tO\n.\tO\n\nTransient\tO\nplatypnea\tB-Disease\n-\tI-Disease\northodeoxia\tI-Disease\n-\tI-Disease\nlike\tI-Disease\nsyndrome\tI-Disease\ninduced\tO\nby\tO\npropafenone\tB-Chemical\noverdose\tB-Disease\nin\tO\na\tO\nyoung\tO\nwoman\tO\nwith\tO\nEbstein\tB-Disease\n'\tI-Disease\ns\tI-Disease\nanomaly\tI-Disease\n.\tO\n\nIn\tO\nthis\tO\nreport\tO\nwe\tO\ndescribe\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n37\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwhite\tO\nwoman\tO\nwith\tO\nEbstein\tB-Disease\n'\tI-Disease\ns\tI-Disease\nanomaly\tI-Disease\n,\tO\nwho\tO\ndeveloped\tO\na\tO\nrare\tO\nsyndrome\tO\ncalled\tO\nplatypnea\tB-Disease\n-\tI-Disease\northodeoxia\tI-Disease\n,\tO\ncharacterized\tO\nby\tO\nmassive\tO\nright\tO\n-\tO\nto\tO\n-\tO\nleft\tO\ninteratrial\tO\nshunting\tO\nwith\tO\ntransient\tO\nprofound\tO\nhypoxia\tB-Disease\nand\tO\ncyanosis\tB-Disease\n.\tO\n\nThis\tO\nshunt\tO\nof\tO\nblood\tO\nvia\tO\na\tO\npatent\tB-Disease\nforamen\tI-Disease\novale\tI-Disease\noccurred\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\na\tO\nnormal\tO\npulmonary\tO\nartery\tO\npressure\tO\n,\tO\nand\tO\nwas\tO\nprobably\tO\nprecipitated\tO\nby\tO\na\tO\npropafenone\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nThis\tO\ndrug\tO\ncaused\tO\nbiventricular\tB-Disease\ndysfunction\tI-Disease\n,\tO\ndue\tO\nto\tO\nits\tO\nnegative\tO\ninotropic\tO\neffect\tO\n,\tO\nand\tO\nhypotension\tB-Disease\n,\tO\ndue\tO\nto\tO\nits\tO\nperipheral\tO\nvasodilatory\tO\neffect\tO\n.\tO\n\nThese\tO\neffects\tO\ngave\tO\nrise\tO\nto\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\nright\tO\natrial\tO\npressure\tO\nand\tO\na\tO\ndecrease\tO\nin\tO\nthe\tO\nleft\tO\none\tO\nwith\tO\na\tO\nconsequent\tO\nstretching\tO\nof\tO\nthe\tO\nforamen\tO\novale\tO\nand\tO\nthe\tO\ncreation\tO\nof\tO\nmassive\tO\nright\tO\n-\tO\nto\tO\n-\tO\nleft\tO\nshunting\tO\n.\tO\n\nIn\tO\nour\tO\ncase\tO\nthis\tO\ninteratrial\tO\nshunt\tO\nwas\tO\nvery\tO\naccurately\tO\ndetected\tO\nat\tO\nbubble\tO\ncontrast\tO\nechocardiography\tO\n.\tO\n\nNoxious\tO\nchemical\tO\nstimulation\tO\nof\tO\nrat\tO\nfacial\tO\nmucosa\tO\nincreases\tO\nintracranial\tO\nblood\tO\nflow\tO\nthrough\tO\na\tO\ntrigemino\tO\n-\tO\nparasympathetic\tO\nreflex\tO\n-\tO\n-\tO\nan\tO\nexperimental\tO\nmodel\tO\nfor\tO\nvascular\tB-Disease\ndysfunctions\tI-Disease\nin\tO\ncluster\tB-Disease\nheadache\tI-Disease\n.\tO\n\nCluster\tB-Disease\nheadache\tI-Disease\nis\tO\ncharacterized\tO\nby\tO\ntypical\tO\nautonomic\tO\ndysfunctions\tO\nincluding\tO\nfacial\tO\nand\tO\nintracranial\tB-Disease\nvascular\tI-Disease\ndisturbances\tI-Disease\n.\tO\n\nBoth\tO\nthe\tO\ntrigeminal\tO\nand\tO\nthe\tO\ncranial\tO\nparasympathetic\tO\nsystems\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nmediating\tO\nthese\tO\ndysfunctions\tO\n.\tO\n\nAn\tO\nexperimental\tO\nmodel\tO\nwas\tO\ndeveloped\tO\nin\tO\nthe\tO\nrat\tO\nto\tO\nmeasure\tO\nchanges\tO\nin\tO\nlacrimation\tO\nand\tO\nintracranial\tO\nblood\tO\nflow\tO\nfollowing\tO\nnoxious\tO\nchemical\tO\nstimulation\tO\nof\tO\nfacial\tO\nmucosa\tO\n.\tO\n\nBlood\tO\nflow\tO\nwas\tO\nmonitored\tO\nin\tO\narteries\tO\nof\tO\nthe\tO\nexposed\tO\ncranial\tO\ndura\tO\nmater\tO\nand\tO\nthe\tO\nparietal\tO\ncortex\tO\nusing\tO\nlaser\tO\nDoppler\tO\nflowmetry\tO\n.\tO\n\nCapsaicin\tB-Chemical\n(\tO\n0\tO\n.\tO\n01\tO\n-\tO\n1\tO\nmm\tO\n)\tO\napplied\tO\nto\tO\noral\tO\nor\tO\nnasal\tO\nmucosa\tO\ninduced\tO\nincreases\tB-Disease\nin\tI-Disease\ndural\tI-Disease\nand\tI-Disease\ncortical\tI-Disease\nblood\tI-Disease\nflow\tI-Disease\nand\tO\nprovoked\tO\nlacrimation\tO\n.\tO\n\nThese\tO\nresponses\tO\nwere\tO\nblocked\tO\nby\tO\nsystemic\tO\npre\tO\n-\tO\nadministration\tO\nof\tO\nhexamethonium\tB-Chemical\nchloride\tI-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nThe\tO\nevoked\tO\nincreases\tB-Disease\nin\tI-Disease\ndural\tI-Disease\nblood\tI-Disease\nflow\tI-Disease\nwere\tO\nalso\tO\nabolished\tO\nby\tO\ntopical\tO\npre\tO\n-\tO\nadministration\tO\nof\tO\natropine\tB-Chemical\n(\tO\n1\tO\nmm\tO\n)\tO\nand\tO\n[\tO\nLys1\tO\n,\tO\nPro2\tO\n,\tO\n5\tO\n,\tO\nArg3\tO\n,\tO\n4\tO\n,\tO\nTyr6\tO\n]\tO\n-\tO\nVIP\tO\n(\tO\n0\tO\n.\tO\n1\tO\nmm\tO\n)\tO\n,\tO\na\tO\nvasoactive\tO\nintestinal\tO\npolypeptide\tO\n(\tO\nVIP\tO\n)\tO\nantagonist\tO\n,\tO\nonto\tO\nthe\tO\nexposed\tO\ndura\tO\nmater\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nnoxious\tO\nstimulation\tO\nof\tO\nfacial\tO\nmucosa\tO\nincreases\tO\nintracranial\tO\nblood\tO\nflow\tO\nand\tO\nlacrimation\tO\nvia\tO\na\tO\ntrigemino\tO\n-\tO\nparasympathetic\tO\nreflex\tO\n.\tO\n\nThe\tO\nblood\tO\nflow\tO\nresponses\tO\nseem\tO\nto\tO\nbe\tO\nmediated\tO\nby\tO\nthe\tO\nrelease\tO\nof\tO\nacetylcholine\tB-Chemical\nand\tO\nVIP\tO\nwithin\tO\nthe\tO\nmeninges\tO\n.\tO\n\nSimilar\tO\nmechanisms\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\ncluster\tB-Disease\nheadache\tI-Disease\n.\tO\n\nOrganophosphate\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nand\tO\nprevention\tO\nof\tO\nneuropathological\tB-Disease\ndamages\tI-Disease\n.\tO\n\nSuch\tO\norganophosphorus\tB-Chemical\n(\tO\nOP\tB-Chemical\n)\tO\ncompounds\tO\nas\tO\ndiisopropylfluorophosphate\tB-Chemical\n(\tO\nDFP\tB-Chemical\n)\tO\n,\tO\nsarin\tB-Chemical\nand\tO\nsoman\tB-Chemical\nare\tO\npotent\tO\ninhibitors\tO\nof\tO\nacetylcholinesterases\tO\n(\tO\nAChEs\tO\n)\tO\nand\tO\nbutyrylcholinesterases\tO\n(\tO\nBChEs\tO\n)\tO\n.\tO\n\nThe\tO\nacute\tO\ntoxicity\tB-Disease\nof\tO\nOPs\tB-Chemical\nis\tO\nthe\tO\nresult\tO\nof\tO\ntheir\tO\nirreversible\tO\nbinding\tO\nwith\tO\nAChEs\tO\nin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n(\tO\nCNS\tO\n)\tO\n,\tO\nwhich\tO\nelevates\tO\nacetylcholine\tB-Chemical\n(\tO\nACh\tB-Chemical\n)\tO\nlevels\tO\n.\tO\n\nThe\tO\nprotective\tO\naction\tO\nof\tO\nsubcutaneously\tO\n(\tO\nSC\tO\n)\tO\nadministered\tO\nantidotes\tO\nor\tO\ntheir\tO\ncombinations\tO\nin\tO\nDFP\tB-Chemical\n(\tO\n2\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n)\tO\nintoxication\tO\nwas\tO\nstudied\tO\nin\tO\n9\tO\n-\tO\n10\tO\n-\tO\nweeks\tO\n-\tO\nold\tO\nHan\tO\n-\tO\nWistar\tO\nmale\tO\nrats\tO\n.\tO\n\nThe\tO\nrats\tO\nreceived\tO\nAChE\tO\nreactivator\tO\npralidoxime\tB-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nchloride\tI-Chemical\n(\tO\n2PAM\tB-Chemical\n)\tO\n(\tO\n30\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n)\tO\n,\tO\nanticonvulsant\tO\ndiazepam\tB-Chemical\n(\tO\n2\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n)\tO\n,\tO\nA\tO\n(\tO\n1\tO\n)\tO\n-\tO\nadenosine\tB-Chemical\nreceptor\tO\nagonist\tO\nN\tB-Chemical\n(\tI-Chemical\n6\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\ncyclopentyl\tI-Chemical\nadenosine\tI-Chemical\n(\tO\nCPA\tB-Chemical\n)\tO\n(\tO\n2\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n)\tO\n,\tO\nNMDA\tB-Chemical\n-\tO\nreceptor\tO\nantagonist\tO\ndizocilpine\tB-Chemical\nmaleate\tI-Chemical\n(\tO\n+\tO\n-\tO\nMK801\tO\nhydrogen\tO\nmaleate\tO\n)\tO\n(\tO\n2\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n)\tO\nor\tO\ntheir\tO\ncombinations\tO\nwith\tO\ncholinolytic\tO\ndrug\tO\natropine\tB-Chemical\nsulfate\tI-Chemical\n(\tO\n50\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n)\tO\nimmediately\tO\nor\tO\n30\tO\nmin\tO\nafter\tO\nthe\tO\nsingle\tO\nSC\tO\ninjection\tO\nof\tO\nDFP\tB-Chemical\n.\tO\n\nThe\tO\ncontrol\tO\nrats\tO\nreceived\tO\natropine\tB-Chemical\nsulfate\tI-Chemical\n,\tO\nbut\tO\nalso\tO\nsaline\tO\nand\tO\nolive\tO\noil\tO\ninstead\tO\nof\tO\nother\tO\nantidotes\tO\nand\tO\nDFP\tB-Chemical\n,\tO\nrespectively\tO\n.\tO\n\nAll\tO\nrats\tO\nwere\tO\nterminated\tO\neither\tO\n24\tO\nh\tO\nor\tO\n3\tO\nweeks\tO\nafter\tO\nthe\tO\nDFP\tB-Chemical\ninjection\tO\n.\tO\n\nThe\tO\nrats\tO\ntreated\tO\nwith\tO\nDFP\tB-Chemical\n-\tO\natropine\tB-Chemical\nshowed\tO\nsevere\tO\ntypical\tO\nOP\tB-Chemical\n-\tO\ninduced\tO\ntoxicity\tB-Disease\nsigns\tO\n.\tO\n\nWhen\tO\nCPA\tB-Chemical\n,\tO\ndiazepam\tB-Chemical\nor\tO\n2PAM\tB-Chemical\nwas\tO\ngiven\tO\nimmediately\tO\nafter\tO\nDFP\tB-Chemical\n-\tO\natropine\tB-Chemical\n,\tO\nthese\tO\ntreatments\tO\nprevented\tO\n,\tO\ndelayed\tO\nor\tO\nshortened\tO\nthe\tO\noccurrence\tO\nof\tO\nserious\tO\nsigns\tO\nof\tO\npoisoning\tB-Disease\n.\tO\n\nAtropine\tB-Chemical\n-\tO\nMK801\tB-Chemical\ndid\tO\nnot\tO\noffer\tO\nany\tO\nadditional\tO\nprotection\tO\nagainst\tO\nDFP\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nCPA\tB-Chemical\n,\tO\ndiazepam\tB-Chemical\nand\tO\n2PAM\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\natropine\tB-Chemical\nprevented\tO\nthe\tO\noccurrence\tO\nof\tO\nserious\tO\nsigns\tO\nof\tO\npoisoning\tB-Disease\nand\tO\nthus\tO\nreduced\tO\nthe\tO\ntoxicity\tB-Disease\nof\tO\nDFP\tB-Chemical\nin\tO\nrat\tO\n.\tO\n\nA\tO\npyridoxine\tB-Chemical\n-\tO\ndependent\tO\nbehavioral\tB-Disease\ndisorder\tI-Disease\nunmasked\tO\nby\tO\nisoniazid\tB-Chemical\n.\tO\n\nA\tO\n3\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ngirl\tO\nhad\tO\nbehavioral\tB-Disease\ndeterioration\tI-Disease\n,\tO\nwith\tO\nhyperkinesis\tB-Disease\n,\tO\nirritability\tB-Disease\n,\tO\nand\tO\nsleeping\tB-Disease\ndifficulties\tI-Disease\nafter\tO\nthe\tO\ntherapeutic\tO\nadministration\tO\nof\tO\nisoniazid\tB-Chemical\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\npharmacologic\tO\ndoses\tO\nof\tO\npyridoxine\tB-Chemical\nhydrochloride\tI-Chemical\nled\tO\nto\tO\na\tO\ndisappearance\tO\nof\tO\nsymptoms\tO\n.\tO\n\nAfter\tO\ndiscontinuing\tO\nisoniazid\tB-Chemical\ntherapy\tO\na\tO\nsimilar\tO\npattern\tO\nof\tO\nbehavior\tO\nwas\tO\nnoted\tO\nthat\tO\nwas\tO\ncontrolled\tO\nby\tO\npyridoxine\tB-Chemical\n.\tO\n\nA\tO\nplacebo\tO\nhad\tO\nno\tO\neffect\tO\n,\tO\nbut\tO\nniacinamide\tB-Chemical\nwas\tO\nas\tO\neffective\tO\nas\tO\npyridoxine\tB-Chemical\n.\tO\n\nPeriodic\tO\nwithdrawal\tO\nof\tO\npyridoxine\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\nreturn\tO\nof\tO\nthe\tO\nhyperkinesis\tB-Disease\n.\tO\n\nThe\tO\nlevel\tO\nof\tO\npyridoxal\tB-Chemical\nin\tO\nthe\tO\nblood\tO\nwas\tO\nnormal\tO\nduring\tO\nthe\tO\nperiods\tO\nof\tO\nrelapse\tO\n.\tO\n\nMetabolic\tO\nstudies\tO\nsuggested\tO\na\tO\nblock\tO\nin\tO\nthe\tO\nkynurenine\tB-Chemical\npathway\tO\nof\tO\ntryptophan\tB-Chemical\nmetabolism\tO\n.\tO\n\nThe\tO\npatient\tO\nhas\tO\nbeen\tO\nfollowed\tO\nfor\tO\nsix\tO\nyears\tO\nand\tO\nhas\tO\nrequired\tO\npharmacologic\tO\ndoses\tO\nof\tO\npyridoxine\tB-Chemical\nto\tO\ncontrol\tO\nher\tO\nbehavior\tO\n.\tO\n\nRecurrent\tO\nexcitation\tO\nin\tO\nthe\tO\ndentate\tO\ngyrus\tO\nof\tO\na\tO\nmurine\tO\nmodel\tO\nof\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\n.\tO\n\nSimilar\tO\nto\tO\nrats\tO\n,\tO\nsystemic\tO\npilocarpine\tB-Chemical\ninjection\tO\ncauses\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n(\tO\nSE\tB-Disease\n)\tO\nand\tO\nthe\tO\neventual\tO\ndevelopment\tO\nof\tO\nspontaneous\tO\nseizures\tB-Disease\nand\tO\nmossy\tO\nfiber\tO\nsprouting\tO\nin\tO\nC57BL\tO\n/\tO\n6\tO\nand\tO\nCD1\tO\nmice\tO\n,\tO\nbut\tO\nthe\tO\nphysiological\tO\ncorrelates\tO\nof\tO\nthese\tO\nevents\tO\nhave\tO\nnot\tO\nbeen\tO\nidentified\tO\nin\tO\nmice\tO\n.\tO\n\nPopulation\tO\nresponses\tO\nin\tO\ngranule\tO\ncells\tO\nof\tO\nthe\tO\ndentate\tO\ngyrus\tO\nwere\tO\nexamined\tO\nin\tO\ntransverse\tO\nslices\tO\nof\tO\nthe\tO\nventral\tO\nhippocampus\tO\nfrom\tO\npilocarpine\tB-Chemical\n-\tO\ntreated\tO\nand\tO\nuntreated\tO\nmice\tO\n.\tO\n\nIn\tO\nMg\tB-Chemical\n(\tO\n2\tO\n+\tO\n)\tO\n-\tO\nfree\tO\nbathing\tO\nmedium\tO\ncontaining\tO\nbicuculline\tB-Chemical\n,\tO\nconditions\tO\ndesigned\tO\nto\tO\nincrease\tO\nexcitability\tO\nin\tO\nthe\tO\nslices\tO\n,\tO\nelectrical\tO\nstimulation\tO\nof\tO\nthe\tO\nhilus\tO\nresulted\tO\nin\tO\na\tO\nsingle\tO\npopulation\tO\nspike\tO\nin\tO\ngranule\tO\ncells\tO\nfrom\tO\ncontrol\tO\nmice\tO\nand\tO\npilocarpine\tB-Chemical\n-\tO\ntreated\tO\nmice\tO\nthat\tO\ndid\tO\nnot\tO\nexperience\tO\nSE\tB-Disease\n.\tO\n\nIn\tO\nSE\tB-Disease\nsurvivors\tO\n,\tO\nsimilar\tO\nstimulation\tO\nresulted\tO\nin\tO\na\tO\npopulation\tO\nspike\tO\nfollowed\tO\n,\tO\nat\tO\na\tO\nvariable\tO\nlatency\tO\n,\tO\nby\tO\nnegative\tO\nDC\tO\nshifts\tO\nand\tO\nrepetitive\tO\nafterdischarges\tO\nof\tO\n3\tO\n-\tO\n60\tO\ns\tO\nduration\tO\n,\tO\nwhich\tO\nwere\tO\nblocked\tO\nby\tO\nionotropic\tO\nglutamate\tB-Chemical\nreceptor\tO\nantagonists\tO\n.\tO\n\nFocal\tO\nglutamate\tB-Chemical\nphotostimulation\tO\nof\tO\nthe\tO\ngranule\tO\ncell\tO\nlayer\tO\nat\tO\nsites\tO\ndistant\tO\nfrom\tO\nthe\tO\nrecording\tO\npipette\tO\nresulted\tO\nin\tO\npopulation\tO\nresponses\tO\nof\tO\n1\tO\n-\tO\n30\tO\ns\tO\nduration\tO\nin\tO\nslices\tO\nfrom\tO\nSE\tB-Disease\nsurvivors\tO\nbut\tO\nnot\tO\nother\tO\ngroups\tO\n.\tO\n\nThese\tO\ndata\tO\nsupport\tO\nthe\tO\nhypothesis\tO\nthat\tO\nSE\tB-Disease\n-\tO\ninduced\tO\nmossy\tO\nfiber\tO\nsprouting\tO\nand\tO\nsynaptic\tO\nreorganization\tO\nare\tO\nrelevant\tO\ncharacteristics\tO\nof\tO\nseizure\tB-Disease\ndevelopment\tO\nin\tO\nthese\tO\nmurine\tO\nstrains\tO\n,\tO\nresembling\tO\nrat\tO\nmodels\tO\nof\tO\nhuman\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\n.\tO\n\nUrinary\tB-Disease\nbladder\tI-Disease\ncancer\tI-Disease\nin\tO\nWegener\tB-Disease\n'\tI-Disease\ns\tI-Disease\ngranulomatosis\tI-Disease\n:\tO\nrisks\tO\nand\tO\nrelation\tO\nto\tO\ncyclophosphamide\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nassess\tO\nand\tO\ncharacterise\tO\nthe\tO\nrisk\tO\nof\tO\nbladder\tB-Disease\ncancer\tI-Disease\n,\tO\nand\tO\nits\tO\nrelation\tO\nto\tO\ncyclophosphamide\tB-Chemical\n,\tO\nin\tO\npatients\tO\nwith\tO\nWegener\tB-Disease\n'\tI-Disease\ns\tI-Disease\ngranulomatosis\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nIn\tO\nthe\tO\npopulation\tO\nbased\tO\n,\tO\nnationwide\tO\nSwedish\tO\nInpatient\tO\nRegister\tO\na\tO\ncohort\tO\nof\tO\n1065\tO\npatients\tO\nwith\tO\nWegener\tB-Disease\n'\tI-Disease\ns\tI-Disease\ngranulomatosis\tI-Disease\n,\tO\n1969\tO\n-\tO\n95\tO\n,\tO\nwas\tO\nidentified\tO\n.\tO\n\nThrough\tO\nlinkage\tO\nwith\tO\nthe\tO\nSwedish\tO\nCancer\tB-Disease\nRegister\tO\n,\tO\nall\tO\nsubjects\tO\nin\tO\nthis\tO\ncohort\tO\ndiagnosed\tO\nwith\tO\nbladder\tB-Disease\ncancer\tI-Disease\nwere\tO\nidentified\tO\n.\tO\n\nNested\tO\nwithin\tO\nthe\tO\ncohort\tO\n,\tO\na\tO\nmatched\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nwas\tO\nperformed\tO\nto\tO\nestimate\tO\nthe\tO\nassociation\tO\nbetween\tO\ncyclophosphamide\tB-Chemical\nand\tO\nbladder\tB-Disease\ncancer\tI-Disease\nusing\tO\nodds\tO\nratios\tO\n(\tO\nORs\tO\n)\tO\nas\tO\nrelative\tO\nrisk\tO\n.\tO\n\nIn\tO\nthe\tO\ncohort\tO\nthe\tO\ncumulative\tO\nrisk\tO\nof\tO\nbladder\tB-Disease\ncancer\tI-Disease\nafter\tO\nWegener\tB-Disease\n'\tI-Disease\ns\tI-Disease\ngranulomatosis\tI-Disease\n,\tO\nand\tO\nthe\tO\nrelative\tO\nprevalence\tO\nof\tO\na\tO\nhistory\tO\nof\tO\nbladder\tB-Disease\ncancer\tI-Disease\nat\tO\nthe\tO\ntime\tO\nof\tO\ndiagnosis\tO\nof\tO\nWegener\tB-Disease\n'\tI-Disease\ns\tI-Disease\ngranulomatosis\tI-Disease\n,\tO\nwere\tO\nalso\tO\nestimated\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nmedian\tO\ncumulative\tO\ndoses\tO\nof\tO\ncyclophosphamide\tB-Chemical\namong\tO\ncases\tO\n(\tO\nn\tO\n=\tO\n11\tO\n)\tO\nand\tO\ncontrols\tO\n(\tO\nn\tO\n=\tO\n25\tO\n)\tO\nwere\tO\n113\tO\ng\tO\nand\tO\n25\tO\ng\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nbladder\tB-Disease\ncancer\tI-Disease\ndoubled\tO\nfor\tO\nevery\tO\n10\tO\ng\tO\nincrement\tO\nin\tO\ncyclophosphamide\tB-Chemical\n(\tO\nOR\tO\n=\tO\n2\tO\n.\tO\n0\tO\n,\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n(\tO\nCI\tO\n)\tO\n0\tO\n.\tO\n8\tO\nto\tO\n4\tO\n.\tO\n9\tO\n)\tO\n.\tO\n\nTreatment\tO\nduration\tO\nlonger\tO\nthan\tO\n1\tO\nyear\tO\nwas\tO\nassociated\tO\nwith\tO\nan\tO\neightfold\tO\nincreased\tO\nrisk\tO\n(\tO\nOR\tO\n=\tO\n7\tO\n.\tO\n7\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n9\tO\nto\tO\n69\tO\n)\tO\n.\tO\n\nThe\tO\nabsolute\tO\nrisk\tO\nfor\tO\nbladder\tB-Disease\ncancer\tI-Disease\nin\tO\nthe\tO\ncohort\tO\nreached\tO\n10\tO\n%\tO\n16\tO\nyears\tO\nafter\tO\ndiagnosis\tO\nof\tO\nWegener\tB-Disease\n'\tI-Disease\ns\tI-Disease\ngranulomatosis\tI-Disease\n,\tO\nand\tO\na\tO\nhistory\tO\nof\tO\nbladder\tB-Disease\ncancer\tI-Disease\nwas\tO\n(\tO\nnon\tO\n-\tO\nsignificantly\tO\n)\tO\ntwice\tO\nas\tO\ncommon\tO\nas\tO\nexpected\tO\nat\tO\nthe\tO\ntime\tO\nof\tO\ndiagnosis\tO\nof\tO\nWegener\tB-Disease\n'\tI-Disease\ns\tI-Disease\ngranulomatosis\tI-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nresults\tO\nindicate\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\nrelationship\tO\nbetween\tO\ncyclophosphamide\tB-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nbladder\tB-Disease\ncancer\tI-Disease\n,\tO\nhigh\tO\ncumulative\tO\nrisks\tO\nin\tO\nthe\tO\nentire\tO\ncohort\tO\n,\tO\nand\tO\nalso\tO\nthe\tO\npossibility\tO\nof\tO\nrisk\tO\nfactors\tO\noperating\tO\neven\tO\nbefore\tO\nWegener\tB-Disease\n'\tI-Disease\ns\tI-Disease\ngranulomatosis\tI-Disease\n.\tO\n\nDifferential\tO\nmodulation\tO\nby\tO\nestrogen\tB-Chemical\nof\tO\nalpha2\tO\n-\tO\nadrenergic\tO\nand\tO\nI1\tO\n-\tO\nimidazoline\tB-Chemical\nreceptor\tO\n-\tO\nmediated\tO\nhypotension\tB-Disease\nin\tO\nfemale\tO\nrats\tO\n.\tO\n\nWe\tO\nhave\tO\nrecently\tO\nshown\tO\nthat\tO\nestrogen\tB-Chemical\nnegatively\tO\nmodulates\tO\nthe\tO\nhypotensive\tB-Disease\neffect\tO\nof\tO\nclonidine\tB-Chemical\n(\tO\nmixed\tO\nalpha2\tO\n-\tO\n/\tO\nI1\tO\n-\tO\nreceptor\tO\nagonist\tO\n)\tO\nin\tO\nfemale\tO\nrats\tO\nand\tO\nimplicates\tO\nthe\tO\ncardiovascular\tO\nautonomic\tO\ncontrol\tO\nin\tO\nthis\tO\ninteraction\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\ninvestigated\tO\nwhether\tO\nthis\tO\neffect\tO\nof\tO\nestrogen\tB-Chemical\ninvolves\tO\ninteraction\tO\nwith\tO\nalpha2\tO\n-\tO\nand\tO\n/\tO\nor\tO\nI1\tO\n-\tO\nreceptors\tO\n.\tO\n\nChanges\tO\nevoked\tO\nby\tO\na\tO\nsingle\tO\nintraperitoneal\tO\ninjection\tO\nof\tO\nrilmenidine\tB-Chemical\n(\tO\n600\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\nor\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyldopa\tI-Chemical\n(\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nselective\tO\nI1\tO\n-\tO\nand\tO\nalpha2\tO\n-\tO\nreceptor\tO\nagonists\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nblood\tO\npressure\tO\n,\tO\nhemodynamic\tO\nvariability\tO\n,\tO\nand\tO\nlocomotor\tO\nactivity\tO\nwere\tO\nassessed\tO\nin\tO\nradiotelemetered\tO\nsham\tO\n-\tO\noperated\tO\nand\tO\novariectomized\tO\n(\tO\nOvx\tO\n)\tO\nSprague\tO\n-\tO\nDawley\tO\nfemale\tO\nrats\tO\nwith\tO\nor\tO\nwithout\tO\n12\tO\n-\tO\nwk\tO\nestrogen\tB-Chemical\nreplacement\tO\n.\tO\n\nThree\tO\ntime\tO\ndomain\tO\nindexes\tO\nof\tO\nhemodynamic\tO\nvariability\tO\nwere\tO\nemployed\tO\n:\tO\nthe\tO\nstandard\tO\ndeviation\tO\nof\tO\nmean\tO\narterial\tO\npressure\tO\nas\tO\na\tO\nmeasure\tO\nof\tO\nblood\tO\npressure\tO\nvariability\tO\nand\tO\nthe\tO\nstandard\tO\ndeviation\tO\nof\tO\nbeat\tO\n-\tO\nto\tO\n-\tO\nbeat\tO\nintervals\tO\n(\tO\nSDRR\tO\n)\tO\nand\tO\nthe\tO\nroot\tO\nmean\tO\nsquare\tO\nof\tO\nsuccessive\tO\ndifferences\tO\nin\tO\nR\tO\n-\tO\nwave\tO\n-\tO\nto\tO\n-\tO\nR\tO\n-\tO\nwave\tO\nintervals\tO\nas\tO\nmeasures\tO\nof\tO\nheart\tO\nrate\tO\nvariability\tO\n.\tO\n\nIn\tO\nsham\tO\n-\tO\noperated\tO\nrats\tO\n,\tO\nrilmenidine\tB-Chemical\nor\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyldopa\tI-Chemical\nelicited\tO\nsimilar\tO\nhypotension\tB-Disease\nthat\tO\nlasted\tO\nat\tO\nleast\tO\n5\tO\nh\tO\nand\tO\nwas\tO\nassociated\tO\nwith\tO\nreductions\tO\nin\tO\nstandard\tO\ndeviation\tO\nof\tO\nmean\tO\narterial\tO\npressure\tO\n.\tO\n\nSDRR\tO\nwas\tO\nreduced\tO\nonly\tO\nby\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyldopa\tI-Chemical\n.\tO\n\nOvx\tO\nsignificantly\tO\nenhanced\tO\nthe\tO\nhypotensive\tB-Disease\nresponse\tO\nto\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyldopa\tI-Chemical\n,\tO\nin\tO\ncontrast\tO\nto\tO\nno\tO\neffect\tO\non\tO\nrilmenidine\tB-Chemical\nhypotension\tB-Disease\n.\tO\n\nThe\tO\nenhanced\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyldopa\tI-Chemical\nhypotension\tB-Disease\nin\tO\nOvx\tO\nrats\tO\nwas\tO\nparalleled\tO\nwith\tO\nfurther\tO\nreduction\tO\nin\tO\nSDRR\tO\nand\tO\na\tB-Disease\nreduced\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\n.\tO\n\nEstrogen\tO\nreplacement\tO\n(\tO\n17beta\tB-Chemical\n-\tI-Chemical\nestradiol\tI-Chemical\nsubcutaneous\tO\npellet\tO\n,\tO\n14\tO\n.\tO\n2\tO\nmicrog\tO\n/\tO\nday\tO\n,\tO\n12\tO\nwk\tO\n)\tO\nof\tO\nOvx\tO\nrats\tO\nrestored\tO\nthe\tO\nhemodynamic\tO\nand\tO\nlocomotor\tO\neffects\tO\nof\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyldopa\tI-Chemical\nto\tO\nsham\tO\n-\tO\noperated\tO\nlevels\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nestrogen\tB-Chemical\ndownregulates\tO\nalpha2\tO\n-\tO\nbut\tO\nnot\tO\nI1\tO\n-\tO\nreceptor\tO\n-\tO\nmediated\tO\nhypotension\tB-Disease\nand\tO\nhighlight\tO\na\tO\nrole\tO\nfor\tO\nthe\tO\ncardiac\tO\nautonomic\tO\ncontrol\tO\nin\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyldopa\tI-Chemical\n-\tO\nestrogen\tB-Chemical\ninteraction\tO\n.\tO\n\nSevere\tO\nreversible\tO\nleft\tB-Disease\nventricular\tI-Disease\nsystolic\tI-Disease\nand\tI-Disease\ndiastolic\tI-Disease\ndysfunction\tI-Disease\ndue\tO\nto\tO\naccidental\tO\niatrogenic\tO\nepinephrine\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nCatecholamine\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\ndue\tO\nto\tO\nchronic\tO\nexcess\tO\nof\tO\nendogenous\tO\ncatecholamines\tB-Chemical\nhas\tO\nbeen\tO\nrecognized\tO\nfor\tO\ndecades\tO\nas\tO\na\tO\nclinical\tO\nphenomenon\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nreports\tO\nof\tO\nmyocardial\tB-Disease\ndysfunction\tI-Disease\ndue\tO\nto\tO\nacute\tO\niatrogenic\tO\noverdose\tB-Disease\nare\tO\nrare\tO\n.\tO\n\nA\tO\n35\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwhose\tO\ncervix\tO\nuteri\tO\nwas\tO\ninadvertently\tO\ninjected\tO\nwith\tO\n8\tO\nmg\tO\nof\tO\nepinephrine\tB-Chemical\ndeveloped\tO\nmyocardial\tB-Disease\nstunning\tI-Disease\nthat\tO\nwas\tO\ncharacterized\tO\nby\tO\nsevere\tO\nhemodynamic\tO\ncompromise\tO\n,\tO\nprofound\tO\n,\tO\nalbeit\tO\ntransient\tO\n,\tO\nleft\tB-Disease\nventricular\tI-Disease\nsystolic\tI-Disease\nand\tI-Disease\ndiastolic\tI-Disease\ndysfunction\tI-Disease\n,\tO\nand\tO\nonly\tO\nmodestly\tO\nelevated\tO\nbiochemical\tO\nmarkers\tO\nof\tO\nmyocardial\tB-Disease\nnecrosis\tI-Disease\n.\tO\n\nOur\tO\ncase\tO\nillustrates\tO\nthe\tO\nserious\tO\nconsequences\tO\nof\tO\nmedical\tO\nerrors\tO\nthat\tO\ncan\tO\nbe\tO\navoided\tO\nthrough\tO\nimproved\tO\nmedication\tO\nlabeling\tO\nand\tO\nstaff\tO\nsupervision\tO\n.\tO\n\nCardioprotective\tO\neffect\tO\nof\tO\ntincture\tB-Chemical\nof\tI-Chemical\nCrataegus\tI-Chemical\non\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nTincture\tB-Chemical\nof\tI-Chemical\nCrataegus\tI-Chemical\n(\tO\nTCR\tB-Chemical\n)\tO\n,\tO\nan\tO\nalcoholic\tB-Chemical\nextract\tI-Chemical\nof\tI-Chemical\nthe\tI-Chemical\nberries\tI-Chemical\nof\tI-Chemical\nhawthorn\tI-Chemical\n(\tO\nCrataegus\tB-Chemical\noxycantha\tI-Chemical\n)\tO\n,\tO\nis\tO\nused\tO\nin\tO\nherbal\tO\nand\tO\nhomeopathic\tO\nmedicine\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndone\tO\nto\tO\ninvestigate\tO\nthe\tO\nprotective\tO\neffect\tO\nof\tO\nTCR\tB-Chemical\non\tO\nexperimentally\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nPretreatment\tO\nof\tO\nTCR\tB-Chemical\n,\tO\nat\tO\na\tO\ndose\tO\nof\tO\n0\tO\n.\tO\n5\tO\nmL\tO\n/\tO\n100\tO\ng\tO\nbodyweight\tO\nper\tO\nday\tO\n,\tO\norally\tO\nfor\tO\n30\tO\ndays\tO\n,\tO\nprevented\tO\nthe\tO\nincrease\tO\nin\tO\nlipid\tO\nperoxidation\tO\nand\tO\nactivity\tO\nof\tO\nmarker\tO\nenzymes\tO\nobserved\tO\nin\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nrats\tO\n(\tO\n85\tO\nmg\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\ns\tO\n.\tO\nc\tO\n.\tO\nfor\tO\n2\tO\ndays\tO\nat\tO\nan\tO\ninterval\tO\nof\tO\n24\tO\nh\tO\n)\tO\n.\tO\n\nTCR\tB-Chemical\nprevented\tO\nthe\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\ndecrease\tO\nin\tO\nantioxidant\tO\nenzymes\tO\nin\tO\nthe\tO\nheart\tO\nand\tO\nincreased\tO\nthe\tO\nrate\tO\nof\tO\nADP\tB-Chemical\n-\tO\nstimulated\tO\noxygen\tB-Chemical\nuptake\tO\nand\tO\nrespiratory\tO\ncoupling\tO\nratio\tO\n.\tO\n\nTCR\tB-Chemical\nprotected\tO\nagainst\tO\npathological\tO\nchanges\tO\ninduced\tO\nby\tO\nisoproterenol\tB-Chemical\nin\tO\nrat\tO\nheart\tO\n.\tO\n\nThe\tO\nresults\tO\nshow\tO\nthat\tO\npretreatment\tO\nwith\tO\nTCR\tB-Chemical\nmay\tO\nbe\tO\nuseful\tO\nin\tO\npreventing\tO\nthe\tO\ndamage\tO\ninduced\tO\nby\tO\nisoproterenol\tB-Chemical\nin\tO\nrat\tO\nheart\tO\n.\tO\n\nTreatment\tO\nof\tO\ntinnitus\tB-Disease\nby\tO\nintratympanic\tO\ninstillation\tO\nof\tO\nlignocaine\tB-Chemical\n(\tO\nlidocaine\tB-Chemical\n)\tO\n2\tO\nper\tO\ncent\tO\nthrough\tO\nventilation\tO\ntubes\tO\n.\tO\n\nIdiopathic\tB-Disease\nsubjective\tI-Disease\ntinnitus\tI-Disease\n(\tO\nIST\tB-Disease\n)\tO\nis\tO\none\tO\nof\tO\nthe\tO\nmost\tO\nobscure\tO\notological\tO\npathologies\tO\n.\tO\n\nThis\tO\npaper\tO\npresents\tO\nthe\tO\nresults\tO\nof\tO\ntreating\tO\nIST\tB-Disease\nby\tO\nintratympanic\tO\ninstillation\tO\nof\tO\nlignocaine\tB-Chemical\n(\tO\nlidocaine\tB-Chemical\n)\tO\n2\tO\nper\tO\ncent\tO\nthrough\tO\na\tO\ngrommet\tO\n,\tO\nfor\tO\nfive\tO\nweekly\tO\ncourses\tO\n.\tO\n\nFifty\tO\n-\tO\ntwo\tO\npatients\tO\nsuffering\tO\nfrom\tO\nintractable\tO\ntinnitus\tB-Disease\nentered\tO\nthis\tO\ntherapeutic\tO\ntrial\tO\n,\tO\nbut\tO\nonly\tO\nnine\tO\nfinished\tO\nall\tO\nfive\tO\ncourses\tO\n.\tO\n\nIn\tO\none\tO\npatient\tO\n,\tO\nthe\tO\ntinnitus\tB-Disease\nwas\tO\nalmost\tO\ncompletely\tO\nabolished\tO\n,\tO\nbut\tO\nin\tO\nall\tO\nthe\tO\nnine\tO\npatients\tO\nthe\tO\ndecompensated\tO\ntinnitus\tB-Disease\nchanged\tO\nto\tO\na\tO\ncompensated\tO\none\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthis\tO\nmode\tO\nof\tO\ntreatment\tO\nfor\tO\npatients\tO\nthat\tO\nwere\tO\npreviously\tO\ntreated\tO\nby\tO\ndrugs\tO\n,\tO\nacupuncture\tO\nand\tO\nbiofeedback\tO\n,\tO\nwith\tO\ndisappointing\tO\nresults\tO\n.\tO\n\nPatients\tO\nshould\tO\nbe\tO\nwarned\tO\nabout\tO\nthe\tO\nside\tO\neffects\tO\nof\tO\nvertigo\tB-Disease\nand\tO\nvomiting\tB-Disease\n,\tO\nwhich\tO\nsubsides\tO\ngradually\tO\nwith\tO\nevery\tO\nnew\tO\ninstillation\tO\n,\tO\nand\tO\nthat\tO\nthe\tO\ntinnitus\tB-Disease\nmay\tO\nnot\tO\ndisappear\tO\nbut\tO\nwill\tO\nbe\tO\nalleviated\tO\n,\tO\nenabling\tO\nthem\tO\nto\tO\ncope\tO\nmore\tO\neasily\tO\nwith\tO\nthe\tO\ndisease\tO\nand\tO\nlead\tO\na\tO\nmore\tO\nnormal\tO\nlife\tO\n.\tO\n\nThe\tO\nalpha3\tO\nand\tO\nbeta4\tO\nnicotinic\tO\nacetylcholine\tB-Chemical\nreceptor\tO\nsubunits\tO\nare\tO\nnecessary\tO\nfor\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nhypolocomotion\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nBinding\tO\nof\tO\nnicotine\tB-Chemical\nto\tO\nnicotinic\tO\nacetylcholine\tB-Chemical\nreceptors\tO\n(\tO\nnAChRs\tO\n)\tO\nelicits\tO\na\tO\nseries\tO\nof\tO\ndose\tO\n-\tO\ndependent\tO\nbehaviors\tO\nthat\tO\ngo\tO\nfrom\tO\naltered\tO\nexploration\tO\n,\tO\nsedation\tO\n,\tO\nand\tO\ntremors\tB-Disease\n,\tO\nto\tO\nseizures\tB-Disease\nand\tO\ndeath\tB-Disease\n.\tO\n\nnAChRs\tO\nare\tO\npentameric\tO\nion\tO\nchannels\tO\nusually\tO\ncomposed\tO\nof\tO\nalpha\tO\nand\tO\nbeta\tO\nsubunits\tO\n.\tO\n\nA\tO\ngene\tO\ncluster\tO\ncomprises\tO\nthe\tO\nalpha3\tO\n,\tO\nalpha5\tO\nand\tO\nbeta4\tO\nsubunits\tO\n,\tO\nwhich\tO\ncoassemble\tO\nto\tO\nform\tO\nfunctional\tO\nreceptors\tO\n.\tO\n\nWe\tO\nexamined\tO\nthe\tO\nrole\tO\nof\tO\nthe\tO\nbeta4\tO\nsubunits\tO\nin\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nhypolocomotion\tB-Disease\nin\tO\nbeta4\tO\nhomozygous\tO\nnull\tO\n(\tO\nbeta4\tO\n-\tO\n/\tO\n-\tO\n)\tO\nand\tO\nalpha3\tO\nheterozygous\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n.\tO\n\nbeta4\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nwere\tO\nless\tO\nsensitive\tO\nto\tO\nthe\tO\neffects\tO\nof\tO\nnicotine\tB-Chemical\nboth\tO\nat\tO\nlow\tO\ndoses\tO\n,\tO\nmeasured\tO\nas\tO\ndecreased\tO\nexploration\tO\nin\tO\nan\tO\nopen\tO\nfield\tO\n,\tO\nand\tO\nat\tO\nhigh\tO\ndoses\tO\n,\tO\nmeasured\tO\nas\tO\nsensitivity\tO\nto\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nUsing\tO\nin\tO\nsitu\tO\nhybridization\tO\nprobes\tO\nfor\tO\nthe\tO\nalpha3\tO\nand\tO\nalpha5\tO\nsubunits\tO\n,\tO\nwe\tO\nshowed\tO\nthat\tO\nalpha5\tO\nmRNA\tO\nlevels\tO\nare\tO\nunchanged\tO\n,\tO\nwhereas\tO\nalpha3\tO\nmRNA\tO\nlevels\tO\nare\tO\nselectively\tO\ndecreased\tO\nin\tO\nthe\tO\nmitral\tO\ncell\tO\nlayer\tO\nof\tO\nthe\tO\nolfactory\tO\nbulb\tO\n,\tO\nand\tO\nthe\tO\ninferior\tO\nand\tO\nthe\tO\nsuperior\tO\ncolliculus\tO\nof\tO\nbeta4\tO\n-\tO\n/\tO\n-\tO\nbrains\tO\n.\tO\n\nalpha3\tO\n+\tO\n/\tO\n-\tO\nmice\tO\nwere\tO\npartially\tO\nresistant\tO\nto\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nwhen\tO\ncompared\tO\nto\tO\nwild\tO\n-\tO\ntype\tO\nlittermates\tO\n.\tO\n\nmRNA\tO\nlevels\tO\nfor\tO\nthe\tO\nalpha5\tO\nand\tO\nthe\tO\nbeta4\tO\nsubunits\tO\nwere\tO\nunchanged\tO\nin\tO\nalpha3\tO\n+\tO\n/\tO\n-\tO\nbrains\tO\n.\tO\n\nTogether\tO\n,\tO\nthese\tO\nresults\tO\nsuggest\tO\nthat\tO\nthe\tO\nbeta4\tO\nand\tO\nthe\tO\nalpha3\tO\nsubunits\tO\nare\tO\nmediators\tO\nof\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nhypolocomotion\tB-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nsevoflurane\tB-Chemical\non\tO\nlidocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nThe\tO\ninfluence\tO\nof\tO\nsevoflurane\tB-Chemical\non\tO\nlidocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nwas\tO\nstudied\tO\nin\tO\ncats\tO\n.\tO\n\nThe\tO\nconvulsive\tB-Disease\nthreshold\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nwas\tO\n41\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n5\tO\nmg\tO\n.\tO\n\nl\tO\n(\tO\n-\tO\n1\tO\n)\tO\nwith\tO\nlidocaine\tB-Chemical\ninfusion\tO\n(\tO\n6\tO\nmg\tO\n.\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n.\tO\nmin\tO\n(\tO\n-\tO\n1\tO\n)\tO\n)\tO\n,\tO\nincreasing\tO\nsignificantly\tO\nto\tO\n66\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n10\tO\n.\tO\n9\tO\nmg\tO\n.\tO\n\nl\tO\n(\tO\n-\tO\n1\tO\n)\tO\nwhen\tO\nthe\tO\nend\tO\n-\tO\ntidal\tO\nconcentration\tO\nof\tO\nsevoflurane\tB-Chemical\nwas\tO\n0\tO\n.\tO\n8\tO\n%\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nthreshold\tO\n(\tO\n61\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n8\tO\n.\tO\n7\tO\nmg\tO\n.\tO\nl\tO\n(\tO\n-\tO\n1\tO\n)\tO\n)\tO\nduring\tO\n1\tO\n.\tO\n6\tO\n%\tO\nsevoflurane\tB-Chemical\nwas\tO\nnot\tO\nsignificant\tO\nfrom\tO\nthat\tO\nduring\tO\n0\tO\n.\tO\n8\tO\n%\tO\nsevoflurane\tB-Chemical\n,\tO\nindicating\tO\na\tO\ncelling\tO\neffect\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nsignificant\tO\ndifference\tO\nin\tO\nthe\tO\nconvulsive\tB-Disease\nthreshold\tO\nbetween\tO\nsevoflurane\tB-Chemical\nand\tO\nenflurane\tB-Chemical\n.\tO\n\nThe\tO\nrise\tO\nin\tO\nblood\tO\npressure\tO\nbecame\tO\nless\tO\nmarked\tO\nwhen\tO\nhigher\tO\nconcentrations\tO\nof\tO\nsevoflurane\tB-Chemical\nor\tO\nenflurane\tB-Chemical\nwere\tO\nadministered\tO\nand\tO\nthe\tO\nblood\tO\npressure\tO\nat\tO\nconvulsions\tB-Disease\ndecreased\tO\nsignificantly\tO\nin\tO\n1\tO\n.\tO\n6\tO\n%\tO\nsevoflurane\tB-Chemical\n,\tO\nand\tO\nin\tO\n0\tO\n.\tO\n8\tO\n%\tO\nand\tO\n1\tO\n.\tO\n6\tO\n%\tO\nenflurane\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nwas\tO\nno\tO\nsignificant\tO\ndifference\tO\nin\tO\nthe\tO\nlidocaine\tB-Chemical\nconcentrations\tO\nmeasured\tO\nwhen\tO\nthe\tO\nsystolic\tO\nblood\tO\npressure\tO\nbecame\tO\n70\tO\nmmHg\tO\n.\tO\n\nApamin\tB-Chemical\n,\tO\na\tO\nselective\tO\nblocker\tO\nof\tO\ncalcium\tB-Chemical\n-\tO\ndependent\tO\npotassium\tB-Chemical\nchannels\tO\n,\tO\nwas\tO\nadministered\tO\nintracerebroventricularly\tO\nin\tO\nrats\tO\nanesthetized\tO\nwith\tO\n0\tO\n.\tO\n8\tO\n%\tO\nsevoflurane\tB-Chemical\nto\tO\ninvestigate\tO\nthe\tO\nmechanism\tO\nof\tO\nthe\tO\nanticonvulsive\tO\neffects\tO\n.\tO\n\nApamin\tB-Chemical\n(\tO\n10\tO\nng\tO\n)\tO\nhad\tO\na\tO\ntendency\tO\nto\tO\ndecrease\tO\nthe\tO\nconvulsive\tB-Disease\nthreshold\tO\n(\tO\n21\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n2\tO\nto\tO\n19\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n.\tO\nl\tO\n(\tO\n-\tO\n1\tO\n)\tO\n)\tO\nbut\tO\nthis\tO\nwas\tO\nnot\tO\nstatistically\tO\nsignificant\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\nsevoflurane\tB-Chemical\nreduces\tO\nthe\tO\nconvulsive\tB-Disease\neffect\tO\nof\tO\nlidocaine\tB-Chemical\ntoxicity\tB-Disease\nbut\tO\ncarries\tO\nsome\tO\nrisk\tO\ndue\tO\nto\tO\ncirculatory\tO\ndepression\tB-Disease\n.\tO\n\nCardiac\tB-Disease\ntoxicity\tI-Disease\nobserved\tO\nin\tO\nassociation\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\ncyclophosphamide\tB-Chemical\n-\tO\nbased\tO\nchemotherapy\tO\nfor\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nINTRODUCTION\tO\n:\tO\nCyclophosphamide\tB-Chemical\nis\tO\nan\tO\nalkylating\tO\nagent\tO\ngiven\tO\nfrequently\tO\nas\tO\na\tO\ncomponent\tO\nof\tO\nmany\tO\nconditioning\tO\nregimens\tO\n.\tO\n\nIn\tO\nhigh\tO\ndoses\tO\n,\tO\nits\tO\nnonhematological\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicity\tB-Disease\nis\tO\ncardiomyopathy\tB-Disease\n.\tO\n\nSTUDY\tO\nDESIGN\tO\n:\tO\nWe\tO\ncombined\tO\npaclitaxel\tB-Chemical\n,\tO\nmelphalan\tB-Chemical\nand\tO\nhigh\tO\n-\tO\ndose\tO\ncyclophosphamide\tB-Chemical\n,\tO\nthiotepa\tB-Chemical\n,\tO\nand\tO\ncarboplatin\tB-Chemical\nin\tO\na\tO\ntriple\tO\nsequential\tO\nhigh\tO\n-\tO\ndose\tO\nregimen\tO\nfor\tO\npatients\tO\nwith\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\n.\tO\n\nAnalysis\tO\nwas\tO\nperformed\tO\non\tO\n61\tO\nwomen\tO\nwith\tO\nchemotherapy\tO\n-\tO\nresponsive\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\nreceiving\tO\n96\tO\n-\tO\nh\tO\ninfusional\tO\ncyclophosphamide\tB-Chemical\nas\tO\npart\tO\nof\tO\na\tO\ntriple\tO\nsequential\tO\nhigh\tO\n-\tO\ndose\tO\nregimen\tO\nto\tO\nassess\tO\nassociation\tO\nbetween\tO\npresence\tO\nof\tO\nperitransplant\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n(\tO\nCHF\tB-Disease\n)\tO\nand\tO\nthe\tO\nfollowing\tO\npretreatment\tO\ncharacteristics\tO\n:\tO\npresence\tO\nof\tO\nelectrocardiogram\tO\n(\tO\nEKG\tO\n)\tO\nabnormalities\tO\n,\tO\nage\tO\n,\tO\nhypertension\tB-Disease\n,\tO\nprior\tO\ncardiac\tO\nhistory\tO\n,\tO\nsmoking\tO\n,\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\n,\tO\nprior\tO\nuse\tO\nof\tO\nanthracyclines\tB-Chemical\n,\tO\nand\tO\nleft\tO\n-\tO\nsided\tO\nchest\tO\nirradiation\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSix\tO\nof\tO\n61\tO\nwomen\tO\n(\tO\n10\tO\n%\tO\n)\tO\ndeveloped\tO\nclinically\tO\nreversible\tO\ngrade\tO\n3\tO\nCHF\tB-Disease\nfollowing\tO\ninfusional\tO\ncyclophosphamide\tB-Chemical\nwith\tO\na\tO\nmedian\tO\npercent\tO\ndecline\tO\nin\tO\nejection\tO\nfraction\tO\nof\tO\n31\tO\n%\tO\n.\tO\n\nIncidence\tO\nof\tO\ntransient\tO\ncyclophosphamide\tB-Chemical\n-\tO\nrelated\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\n(\tO\n10\tO\n%\tO\n)\tO\nis\tO\ncomparable\tO\nto\tO\nprevious\tO\nrecorded\tO\nliterature\tO\n.\tO\n\nOlder\tO\nage\tO\nwas\tO\nsignificantly\tO\ncorrelated\tO\nwith\tO\nthe\tO\nCHF\tB-Disease\ndevelopment\tO\n;\tO\nwith\tO\nmedian\tO\nages\tO\nfor\tO\nthe\tO\nentire\tO\ngroup\tO\nand\tO\nfor\tO\npatients\tO\ndeveloping\tO\nCHF\tB-Disease\nof\tO\n45\tO\nand\tO\n59\tO\n,\tO\nrespectively\tO\n.\tO\n\nNo\tO\nassociation\tO\nwas\tO\nfound\tO\nwith\tO\nother\tO\npretreatment\tO\ncharacteristics\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAs\tO\na\tO\nresult\tO\nof\tO\nthese\tO\nfindings\tO\n,\tO\noncologists\tO\nshould\tO\ncarefully\tO\nmonitor\tO\nfluid\tO\nbalance\tO\nin\tO\nolder\tO\npatients\tO\n.\tO\n\nRoutine\tO\nEKG\tO\nmonitoring\tO\nduring\tO\ninfusional\tO\ncyclophosphamide\tB-Chemical\ndid\tO\nnot\tO\npredict\tO\nCHF\tB-Disease\ndevelopment\tO\n.\tO\n\nTremor\tB-Disease\nside\tO\neffects\tO\nof\tO\nsalbutamol\tB-Chemical\n,\tO\nquantified\tO\nby\tO\na\tO\nlaser\tO\npointer\tO\ntechnique\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nstudy\tO\ntremor\tB-Disease\nside\tO\neffects\tO\nof\tO\nsalbutamol\tB-Chemical\nan\tO\neasily\tO\napplicable\tO\n,\tO\nquick\tO\nand\tO\nlow\tO\n-\tO\npriced\tO\nmethod\tO\nis\tO\nneeded\tO\n.\tO\n\nA\tO\nnew\tO\nmethod\tO\nusing\tO\na\tO\ncommercially\tO\navailable\tO\n,\tO\npen\tO\n-\tO\nshaped\tO\nlaser\tO\npointer\tO\nwas\tO\ndeveloped\tO\n.\tO\n\nAim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nsensitivity\tO\n,\tO\nreproducibility\tO\n,\tO\nreference\tO\nvalues\tO\nand\tO\nthe\tO\nagreement\tO\nwith\tO\na\tO\nquestionnaire\tO\n.\tO\n\nMETHODS\tO\n:\tO\nTremor\tB-Disease\nwas\tO\nmeasured\tO\nusing\tO\na\tO\nlaser\tO\npointer\tO\ntechnique\tO\n.\tO\n\nTo\tO\ndetermine\tO\nsensitivity\tO\nwe\tO\nassessed\tO\ntremor\tB-Disease\nin\tO\n44\tO\npatients\tO\nwith\tO\nobstructive\tB-Disease\nlung\tI-Disease\ndisease\tI-Disease\nafter\tO\nadministration\tO\nof\tO\ncumulative\tO\ndoses\tO\nof\tO\nsalbutamol\tB-Chemical\n.\tO\n\nSubjects\tO\nwere\tO\nasked\tO\nto\tO\naim\tO\nat\tO\nthe\tO\ncentre\tO\nof\tO\na\tO\ntarget\tO\n,\tO\nsubdivided\tO\nin\tO\nconcentric\tO\ncircles\tO\n,\tO\nfrom\tO\n5\tO\nm\tO\ndistance\tO\n.\tO\n\nThe\tO\ncircle\tO\nin\tO\nwhich\tO\nthe\tO\nparticipant\tO\nsucceeded\tO\nto\tO\naim\tO\nwas\tO\nrecorded\tO\nin\tO\nmillimetres\tO\nradius\tO\n.\tO\n\nIn\tO\nanother\tO\nseries\tO\nof\tO\nmeasurements\tO\n,\tO\nreproducibility\tO\nand\tO\nreference\tO\nvalues\tO\nof\tO\nthe\tO\ntremor\tB-Disease\nwas\tO\nassessed\tO\nin\tO\n65\tO\nhealthy\tO\nsubjects\tO\nin\tO\nthree\tO\nsessions\tO\n,\tO\nat\tO\n9\tO\na\tO\n.\tO\nm\tO\n.\tO\n,\tO\n4\tO\np\tO\n.\tO\nm\tO\n.\tO\nand\tO\n9\tO\na\tO\n.\tO\nm\tO\n.\tO\n,\tO\nrespectively\tO\n,\tO\n1\tO\nweek\tO\nlater\tO\n.\tO\n\nPostural\tO\ntremor\tB-Disease\nwas\tO\nmeasured\tO\nwith\tO\nthe\tO\narm\tO\nhorizontally\tO\noutstretched\tO\nrest\tO\ntremor\tB-Disease\nwith\tO\nthe\tO\narm\tO\nsupported\tO\nby\tO\nan\tO\narmrest\tO\nand\tO\nfinally\tO\ntremor\tB-Disease\nwas\tO\nmeasured\tO\nafter\tO\nholding\tO\na\tO\n2\tO\n-\tO\nkg\tO\nweight\tO\nuntil\tO\nexhaustion\tO\n.\tO\n\nInter\tO\n-\tO\nobserver\tO\nvariability\tO\nwas\tO\nmeasured\tO\nin\tO\na\tO\nseries\tO\nof\tO\n10\tO\nhealthy\tO\nsubjects\tO\n.\tO\n\nTremor\tB-Disease\nwas\tO\nmeasured\tO\nsimultaneously\tO\nby\tO\ntwo\tO\nindependent\tO\nobservers\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSalbutamol\tB-Chemical\nsignificantly\tO\nincreased\tO\ntremor\tB-Disease\nseverity\tO\nin\tO\npatients\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nway\tO\n.\tO\n\nWithin\tO\nhealthy\tO\nadults\tO\nno\tO\nage\tO\n-\tO\ndependency\tO\ncould\tO\nbe\tO\nfound\tO\n(\tO\nb\tO\n=\tO\n0\tO\n.\tO\n262\tO\nmm\tO\n/\tO\nyear\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n72\tO\n)\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nagreement\tO\nbetween\tO\nthe\tO\nquestionnaire\tO\nand\tO\ntremor\tB-Disease\nseverity\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n093\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n53\tO\n)\tO\n.\tO\n\nPostural\tO\ntremor\tB-Disease\nshowed\tO\nno\tO\nsignificant\tO\ndifference\tO\nbetween\tO\nthe\tO\nfirst\tO\nand\tO\nthird\tO\nsession\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n07\tO\n)\tO\n.\tO\n\nSupport\tO\nof\tO\nthe\tO\narm\tO\ndecreased\tO\ntremor\tB-Disease\nseverity\tO\n,\tO\nexhaustion\tO\nincreased\tO\ntremor\tB-Disease\nseverity\tO\nsignificantly\tO\n.\tO\n\nA\tO\ngood\tO\nagreement\tO\nwas\tO\nfound\tO\nbetween\tO\ntwo\tO\nindependent\tO\nobservers\tO\n(\tO\ninterclass\tO\ncorrelation\tO\ncoefficient\tO\n0\tO\n.\tO\n72\tO\n)\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nQuantifying\tO\ntremor\tB-Disease\nby\tO\nusing\tO\nan\tO\ninexpensive\tO\nlaser\tO\npointer\tO\nis\tO\n,\tO\nwith\tO\nthe\tO\nexception\tO\nof\tO\nchildren\tO\n(\tO\n<\tO\n12\tO\nyears\tO\n)\tO\na\tO\nsensitive\tO\nand\tO\nreproducible\tO\nmethod\tO\n.\tO\n\nSafety\tO\nand\tO\nadverse\tO\neffects\tO\nassociated\tO\nwith\tO\nraloxifene\tB-Chemical\n:\tO\nmultiple\tO\noutcomes\tO\nof\tO\nraloxifene\tB-Chemical\nevaluation\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nexamine\tO\nthe\tO\neffect\tO\nof\tO\nraloxifene\tB-Chemical\non\tO\nmajor\tO\nadverse\tO\nevents\tO\nthat\tO\noccur\tO\nwith\tO\npostmenopausal\tO\nestrogen\tB-Chemical\ntherapy\tO\nor\tO\ntamoxifen\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nMultiple\tO\nOutcomes\tO\nof\tO\nRaloxifene\tB-Chemical\nEvaluation\tO\n,\tO\na\tO\nmulticenter\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\ntrial\tO\n,\tO\nenrolled\tO\n7\tO\n,\tO\n705\tO\npostmenopausal\tO\nwomen\tO\nwith\tO\nosteoporosis\tB-Disease\n.\tO\n\nWomen\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nraloxifene\tB-Chemical\n60\tO\nmg\tO\n/\tO\nd\tO\nor\tO\n120\tO\nmg\tO\n/\tO\nd\tO\nor\tO\nplacebo\tO\n.\tO\n\nOutcomes\tO\nincluded\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n,\tO\ncataracts\tB-Disease\n,\tO\ngallbladder\tB-Disease\ndisease\tI-Disease\n,\tO\nand\tO\nendometrial\tB-Disease\nhyperplasia\tI-Disease\nor\tI-Disease\ncancer\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nDuring\tO\na\tO\nmean\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\n3\tO\n.\tO\n3\tO\nyears\tO\n,\tO\nraloxifene\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nrisk\tO\nfor\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nrelative\tO\nrisk\tO\n[\tO\nRR\tO\n]\tO\n2\tO\n.\tO\n1\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n1\tO\n.\tO\n2\tO\n-\tO\n3\tO\n.\tO\n8\tO\n)\tO\n.\tO\n\nThe\tO\nexcess\tO\nevent\tO\nrate\tO\nwas\tO\n1\tO\n.\tO\n8\tO\nper\tO\n1\tO\n,\tO\n000\tO\nwoman\tO\n-\tO\nyears\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n-\tO\n0\tO\n.\tO\n5\tO\n-\tO\n4\tO\n.\tO\n1\tO\n)\tO\n,\tO\nand\tO\nthe\tO\nnumber\tO\nneeded\tO\nto\tO\ntreat\tO\nto\tO\ncause\tO\n1\tO\nevent\tO\nwas\tO\n170\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n100\tO\n-\tO\n582\tO\n)\tO\nover\tO\n3\tO\n.\tO\n3\tO\nyears\tO\n.\tO\n\nRisk\tO\nin\tO\nthe\tO\nraloxifene\tB-Chemical\ngroup\tO\nwas\tO\nhigher\tO\nthan\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\nfor\tO\nthe\tO\nfirst\tO\n2\tO\nyears\tO\n,\tO\nbut\tO\ndecreased\tO\nto\tO\nabout\tO\nthe\tO\nsame\tO\nrate\tO\nas\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\nthereafter\tO\n.\tO\n\nRaloxifene\tB-Chemical\ndid\tO\nnot\tO\nincrease\tO\nrisk\tO\nfor\tO\ncataracts\tB-Disease\n(\tO\nRR\tO\n0\tO\n.\tO\n9\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n8\tO\n-\tO\n1\tO\n.\tO\n1\tO\n)\tO\n,\tO\ngallbladder\tB-Disease\ndisease\tI-Disease\n(\tO\nRR\tO\n1\tO\n.\tO\n0\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n7\tO\n-\tO\n1\tO\n.\tO\n3\tO\n)\tO\n,\tO\nendometrial\tB-Disease\nhyperplasia\tI-Disease\n(\tO\nRR\tO\n1\tO\n.\tO\n3\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n4\tO\n-\tO\n5\tO\n.\tO\n1\tO\n)\tO\n,\tO\nor\tO\nendometrial\tB-Disease\ncancer\tI-Disease\n(\tO\nRR\tO\n0\tO\n.\tO\n9\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n0\tO\n.\tO\n3\tO\n-\tO\n2\tO\n.\tO\n7\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nRaloxifene\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\nan\tO\nincreased\tO\nrisk\tO\nfor\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n,\tO\nbut\tO\nthere\tO\nwas\tO\nno\tO\nincreased\tO\nrisk\tO\nfor\tO\ncataracts\tB-Disease\n,\tO\ngallbladder\tB-Disease\ndisease\tI-Disease\n,\tO\nendometrial\tB-Disease\nhyperplasia\tI-Disease\n,\tO\nor\tO\nendometrial\tB-Disease\ncancer\tI-Disease\n.\tO\n\nLEVEL\tO\nOF\tO\nEVIDENCE\tO\n:\tO\nI\tO\n\nOptimization\tO\nof\tO\nlevodopa\tB-Chemical\ntherapy\tO\n.\tO\n\nWhile\tO\nthere\tO\nis\tO\nno\tO\nsingle\tO\ncorrect\tO\nstarting\tO\ndose\tO\nfor\tO\nlevodopa\tB-Chemical\ntherapy\tO\n,\tO\nmany\tO\nindividuals\tO\ncan\tO\nbe\tO\nstarted\tO\non\tO\neither\tO\nthe\tO\n25\tO\n/\tO\n100\tO\nor\tO\ncontrolled\tO\n-\tO\nrelease\tO\nformula\tO\n,\tO\nfollowing\tO\nthe\tO\ngeneral\tO\nrule\tO\nnot\tO\nto\tO\nattempt\tO\nto\tO\ntitrate\tO\ncarbidopa\tB-Chemical\n-\tO\nlevodopa\tB-Chemical\nto\tO\nthe\tO\npoint\tO\nof\tO\n\"\tO\nnormality\tO\n,\tO\n\"\tO\nwhich\tO\ncan\tO\nlead\tO\nto\tO\ntoxicity\tB-Disease\n.\tO\n\nThe\tO\nphysician\tO\nshould\tO\nalso\tO\ndetermine\tO\nthe\tO\nproper\tO\nuse\tO\nof\tO\nany\tO\nadjunctive\tO\nmedications\tO\n;\tO\nsuch\tO\ncombined\tO\ntherapy\tO\nhas\tO\nbecome\tO\nthe\tO\nstandard\tO\napproach\tO\nto\tO\ntreatment\tO\n.\tO\n\nFollowing\tO\nthe\tO\ninitial\tO\nperiod\tO\nof\tO\ntherapy\tO\n,\tO\nemerging\tO\ndifficulties\tO\nrequire\tO\na\tO\nreassessment\tO\nof\tO\ntherapeutic\tO\napproaches\tO\n,\tO\nsuch\tO\nas\tO\ndosage\tO\nadjustment\tO\nor\tO\nintroduction\tO\nof\tO\na\tO\ndopamine\tB-Chemical\nagonist\tO\n.\tO\n\nOther\tO\npossible\tO\nadverse\tO\neffects\tO\n-\tO\n-\tO\nsuch\tO\nas\tO\ngastrointestinal\tB-Disease\ndisorders\tI-Disease\n,\tO\northostatic\tB-Disease\nhypotension\tI-Disease\n,\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\npsychosis\tB-Disease\n,\tO\nsleep\tB-Disease\ndisturbances\tI-Disease\nor\tO\nparasomnias\tB-Disease\n,\tO\nor\tO\ndrug\tO\ninteractions\tO\n-\tO\n-\tO\nalso\tO\nrequire\tO\ncarefully\tO\nmonitored\tO\nindividual\tO\ntreatment\tO\n.\tO\n\nNonpharmacologic\tO\nconcerns\tO\ncan\tO\nhelp\tO\nthe\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\npatient\tO\nachieve\tO\nand\tO\nmaintain\tO\noptimal\tO\nfunctioning\tO\n,\tO\nincluding\tO\ndaily\tO\nexercise\tO\n,\tO\nphysical\tO\ntherapy\tO\n,\tO\nand\tO\ninvolvement\tO\nwith\tO\nsupport\tO\ngroups\tO\n.\tO\n\nLong\tO\nterm\tO\naudiological\tO\nevaluation\tO\nof\tO\nbeta\tB-Disease\n-\tI-Disease\nthalassemic\tI-Disease\npatients\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nidentify\tO\nthe\tO\nincidence\tO\nand\tO\nto\tO\nmonitor\tO\nthe\tO\nprogression\tO\nof\tO\nhearing\tB-Disease\nloss\tI-Disease\nin\tO\nchildren\tO\nand\tO\nyoung\tO\nadults\tO\nwith\tO\nbeta\tB-Disease\n-\tI-Disease\nthalassemia\tI-Disease\nmajor\tO\n.\tO\n\nMETHODS\tO\n:\tO\nOne\tO\nhundred\tO\nand\tO\nfour\tO\n(\tO\n104\tO\n)\tO\npatients\tO\naged\tO\n6\tO\n-\tO\n35\tO\nyears\tO\n(\tO\nmean\tO\n17\tO\n,\tO\n2\tO\nyears\tO\n)\tO\nparticipated\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nAll\tO\npatients\tO\nwere\tO\non\tO\na\tO\nregular\tO\ntransfusion\tO\n-\tO\nchelation\tO\nprogram\tO\nmaintaining\tO\na\tO\nmean\tO\nhemoglobin\tO\nlevel\tO\nof\tO\n9\tO\n.\tO\n5\tO\ngr\tO\n/\tO\ndl\tO\n.\tO\n\nSubjects\tO\nwere\tO\nreceiving\tO\ndesferrioxamine\tB-Chemical\n(\tO\nDFO\tB-Chemical\n)\tO\nchelation\tO\ntreatment\tO\nwith\tO\na\tO\nmean\tO\ndaily\tO\ndose\tO\nof\tO\n50\tO\n-\tO\n60\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\n5\tO\n-\tO\n6\tO\ndays\tO\na\tO\nweek\tO\nduring\tO\nthe\tO\nfirst\tO\nsix\tO\nyears\tO\nof\tO\nthe\tO\nstudy\tO\n,\tO\nwhich\tO\nwas\tO\nthen\tO\nreduced\tO\nto\tO\n40\tO\n-\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nfor\tO\nthe\tO\nfollowing\tO\neight\tO\nyears\tO\n.\tO\n\nPatients\tO\nwere\tO\nfollowed\tO\nfor\tO\n8\tO\n-\tO\n14\tO\nyears\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOverall\tO\n,\tO\n21\tO\nout\tO\nof\tO\n104\tO\npatients\tO\n(\tO\n20\tO\n.\tO\n2\tO\n%\tO\n)\tO\npresented\tO\nwith\tO\nhigh\tO\nfrequency\tO\nsensorineural\tB-Disease\nhearing\tI-Disease\nloss\tI-Disease\n(\tO\nSNHL\tB-Disease\n)\tO\n,\tO\neither\tO\nunilateral\tO\nor\tO\nbilateral\tO\n.\tO\n\nNo\tO\nototoxic\tB-Disease\nfactor\tO\n,\tO\nother\tO\nthan\tO\nDFO\tB-Chemical\n,\tO\nwas\tO\npresent\tO\nin\tO\nany\tO\nof\tO\nthe\tO\npatients\tO\n.\tO\n\nPatients\tO\nwith\tO\nSNHL\tB-Disease\npresented\tO\nwith\tO\nrelatively\tO\nlower\tO\nserum\tO\nferritin\tO\nlevels\tO\nthan\tO\nthose\tO\nwith\tO\nnormal\tO\nhearing\tO\n,\tO\nhowever\tO\n,\tO\nno\tO\nstatistically\tO\nsignificant\tO\ndifference\tO\nwas\tO\nobserved\tO\n.\tO\n\nSubjects\tO\nwith\tO\nSNHL\tB-Disease\nwere\tO\nsubmitted\tO\nto\tO\nDFO\tB-Chemical\nreduction\tO\nor\tO\ntemporary\tO\nwithdrawal\tO\n.\tO\n\nFollowing\tO\nintervention\tO\n,\tO\n7\tO\nout\tO\nof\tO\n21\tO\naffected\tO\npatients\tO\nrecovered\tO\n,\tO\n10\tO\nremained\tO\nstable\tO\nand\tO\n4\tO\ndemonstrated\tO\naggravation\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nfindings\tO\nare\tO\nindicative\tO\nof\tO\nDFO\tB-Chemical\n'\tO\ns\tO\ncontributing\tO\nrole\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nhearing\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nRegular\tO\naudiologic\tO\nevaluation\tO\nis\tO\nimperative\tO\nin\tO\nall\tO\nthalassemic\tB-Disease\npatients\tO\nso\tO\nthat\tO\nearly\tO\nchanges\tO\nmay\tO\nbe\tO\nrecognized\tO\nand\tO\ntreatment\tO\nmay\tO\nbe\tO\njudiciously\tO\nadjusted\tO\nin\tO\norder\tO\nto\tO\nprevent\tO\nor\tO\nreverse\tO\nhearing\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nIndividual\tO\ndifferences\tO\nin\tO\nrenal\tO\nACE\tO\nactivity\tO\nin\tO\nhealthy\tO\nrats\tO\npredict\tO\nsusceptibility\tO\nto\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ndamage\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nIn\tO\nman\tO\n,\tO\ndifferences\tO\nin\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\n(\tO\nACE\tO\n)\tO\nlevels\tO\n,\tO\nrelated\tO\nto\tO\nACE\tO\n(\tO\nI\tO\n/\tO\nD\tO\n)\tO\ngenotype\tO\n,\tO\nare\tO\nassociated\tO\nwith\tO\nrenal\tO\nprognosis\tO\n.\tO\n\nThis\tO\nraises\tO\nthe\tO\nhypothesis\tO\nthat\tO\nindividual\tO\ndifferences\tO\nin\tO\nrenal\tO\nACE\tO\nactivity\tO\nare\tO\ninvolved\tO\nin\tO\nrenal\tO\nsusceptibility\tO\nto\tO\ninflicted\tO\ndamage\tO\n.\tO\n\nTherefore\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\npredictive\tO\neffect\tO\nof\tO\nrenal\tO\nACE\tO\nactivity\tO\nfor\tO\nthe\tO\nseverity\tO\nof\tO\nrenal\tB-Disease\ndamage\tI-Disease\ninduced\tO\nby\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\nadriamycin\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nMETHODS\tO\n:\tO\nRenal\tO\nACE\tO\nactivity\tO\n(\tO\nHip\tB-Chemical\n-\tI-Chemical\nHis\tI-Chemical\n-\tI-Chemical\nLeu\tI-Chemical\ncleavage\tO\nby\tO\ncortical\tO\nhomogenates\tO\n)\tO\nwas\tO\ndetermined\tO\nby\tO\nrenal\tO\nbiopsy\tO\nin\tO\n27\tO\nadult\tO\nmale\tO\nWistar\tO\nrats\tO\n.\tO\n\nAfter\tO\n1\tO\nweek\tO\nof\tO\nrecovery\tO\n,\tO\nproteinuria\tB-Disease\nwas\tO\ninduced\tO\nby\tO\nadriamycin\tB-Chemical\n[\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nintravenously\tO\n(\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nn\tO\n=\tO\n18\tO\n;\tO\ncontrols\tO\n,\tO\nsaline\tO\ni\tO\n.\tO\nv\tO\n.\tO\nn\tO\n=\tO\n9\tO\n]\tO\n.\tO\n\nProteinuria\tB-Disease\nwas\tO\nmeasured\tO\nevery\tO\n2\tO\nweeks\tO\n.\tO\n\nAfter\tO\n12\tO\nweeks\tO\n,\tO\nrats\tO\nwere\tO\nsacrificed\tO\nand\tO\ntheir\tO\nkidneys\tO\nharvested\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAs\tO\nanticipated\tO\n,\tO\nadriamycin\tB-Chemical\nelicited\tO\nnephrotic\tB-Disease\nrange\tO\nproteinuria\tB-Disease\n,\tO\nrenal\tB-Disease\ninterstitial\tI-Disease\ndamage\tI-Disease\nand\tO\nmild\tO\nfocal\tB-Disease\nglomerulosclerosis\tI-Disease\n.\tO\n\nBaseline\tO\nrenal\tO\nACE\tO\npositively\tO\ncorrelated\tO\nwith\tO\nthe\tO\nrelative\tO\nrise\tO\nin\tO\nproteinuria\tB-Disease\nafter\tO\nadriamycin\tB-Chemical\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n62\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nrenal\tO\ninterstitial\tO\nalpha\tO\n-\tO\nsmooth\tO\nmuscle\tO\nactin\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n49\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\ninterstitial\tO\nmacrophage\tO\ninflux\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n56\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\ninterstitial\tO\ncollagen\tO\nIII\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n53\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nglomerular\tO\nalpha\tO\n-\tO\nsmooth\tO\nmuscle\tO\nactin\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n74\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nand\tO\nglomerular\tO\ndesmin\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n48\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nBaseline\tO\nrenal\tO\nACE\tO\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nfocal\tB-Disease\nglomerulosclerosis\tI-Disease\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n22\tO\n,\tO\nNS\tO\n)\tO\n.\tO\n\nIn\tO\ncontrols\tO\n,\tO\nno\tO\npredictive\tO\nvalues\tO\nfor\tO\nrenal\tO\nparameters\tO\nwere\tO\nobserved\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIndividual\tO\ndifferences\tO\nin\tO\nrenal\tO\nACE\tO\nactivity\tO\npredict\tO\nthe\tO\nseverity\tO\nof\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ndamage\tI-Disease\nin\tO\nthis\tO\noutbred\tO\nrat\tO\nstrain\tO\n.\tO\n\nThis\tO\nsupports\tO\nthe\tO\nassumption\tO\nthat\tO\ndifferences\tO\nin\tO\nrenal\tO\nACE\tO\nactivity\tO\npredispose\tO\nto\tO\na\tO\nless\tO\nfavourable\tO\ncourse\tO\nof\tO\nrenal\tB-Disease\ndamage\tI-Disease\n.\tO\n\nRecurrent\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\ninduced\tO\nby\tO\nazithromycin\tB-Chemical\n.\tO\n\nA\tO\n14\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ngirl\tO\nis\tO\nreported\tO\nwith\tO\nrecurrent\tO\n,\tO\nazithromycin\tB-Chemical\n-\tO\ninduced\tO\n,\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\n.\tO\n\nThe\tO\nsecond\tO\nepisode\tO\nwas\tO\nmore\tO\nsevere\tO\nthan\tO\nthe\tO\nfirst\tO\n;\tO\nand\tO\nalthough\tO\nboth\tO\nwere\tO\ntreated\tO\nwith\tO\nintensive\tO\ncorticosteroid\tO\ntherapy\tO\n,\tO\nrenal\tO\nfunction\tO\nremained\tO\nimpaired\tO\n.\tO\n\nAlthough\tO\nmost\tO\ncases\tO\nof\tO\nantibiotic\tO\ninduced\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nare\tO\nbenign\tO\nand\tO\nself\tO\n-\tO\nlimited\tO\n,\tO\nsome\tO\npatients\tO\nare\tO\nat\tO\nrisk\tO\nfor\tO\npermanent\tO\nrenal\tB-Disease\ninjury\tI-Disease\n.\tO\n\nSpironolactone\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\nand\tO\nhyperkalemia\tB-Disease\nin\tO\npatients\tO\nwith\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nA\tO\nprevious\tO\nrandomized\tO\ncontrolled\tO\ntrial\tO\nevaluating\tO\nthe\tO\nuse\tO\nof\tO\nspironolactone\tB-Chemical\nin\tO\nheart\tB-Disease\nfailure\tI-Disease\npatients\tO\nreported\tO\na\tO\nlow\tO\nrisk\tO\nof\tO\nhyperkalemia\tB-Disease\n(\tO\n2\tO\n%\tO\n)\tO\nand\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\n(\tO\n0\tO\n%\tO\n)\tO\n.\tO\n\nBecause\tO\ntreatments\tO\nfor\tO\nheart\tB-Disease\nfailure\tI-Disease\nhave\tO\nchanged\tO\nsince\tO\nthe\tO\nbenefits\tO\nof\tO\nspironolactone\tB-Chemical\nwere\tO\nreported\tO\n,\tO\nthe\tO\nprevalence\tO\nof\tO\nthese\tO\ncomplications\tO\nmay\tO\ndiffer\tO\nin\tO\ncurrent\tO\nclinical\tO\npractice\tO\n.\tO\n\nWe\tO\ntherefore\tO\nsought\tO\nto\tO\ndetermine\tO\nthe\tO\nprevalence\tO\nand\tO\nclinical\tO\nassociations\tO\nof\tO\nhyperkalemia\tB-Disease\nand\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\nin\tO\nheart\tB-Disease\nfailure\tI-Disease\npatients\tO\ntreated\tO\nwith\tO\nspironolactone\tB-Chemical\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nperformed\tO\na\tO\ncase\tO\ncontrol\tO\nstudy\tO\nof\tO\nheart\tB-Disease\nfailure\tI-Disease\npatients\tO\ntreated\tO\nwith\tO\nspironolactone\tB-Chemical\nin\tO\nour\tO\nclinical\tO\npractice\tO\n.\tO\n\nCases\tO\nwere\tO\npatients\tO\nwho\tO\ndeveloped\tO\nhyperkalemia\tB-Disease\n(\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\n>\tO\n5\tO\n.\tO\n0\tO\nmEq\tO\n/\tO\nL\tO\n)\tO\nor\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\n(\tO\nCr\tB-Chemical\n>\tO\nor\tO\n=\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndL\tO\n)\tO\n,\tO\nand\tO\nthey\tO\nwere\tO\ncompared\tO\nto\tO\n2\tO\nrandomly\tO\nselected\tO\ncontrols\tO\nper\tO\ncase\tO\n.\tO\n\nClinical\tO\ncharacteristics\tO\n,\tO\nmedications\tO\n,\tO\nand\tO\nserum\tO\nchemistries\tO\nat\tO\nbaseline\tO\nand\tO\nfollow\tO\n-\tO\nup\tO\ntime\tO\nperiods\tO\nwere\tO\ncompared\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSixty\tO\n-\tO\nseven\tO\nof\tO\n926\tO\npatients\tO\n(\tO\n7\tO\n.\tO\n2\tO\n%\tO\n)\tO\nrequired\tO\ndiscontinuation\tO\nof\tO\nspironolactone\tB-Chemical\ndue\tO\nto\tO\nhyperkalemia\tB-Disease\n(\tO\nn\tO\n=\tO\n33\tO\n)\tO\nor\tO\nrenal\tB-Disease\nfailure\tI-Disease\n(\tO\nn\tO\n=\tO\n34\tO\n)\tO\n.\tO\n\nPatients\tO\nwho\tO\ndeveloped\tO\nhyperkalemia\tB-Disease\nwere\tO\nolder\tO\nand\tO\nmore\tO\nlikely\tO\nto\tO\nhave\tO\ndiabetes\tB-Disease\n,\tO\nhad\tO\nhigher\tO\nbaseline\tO\nserum\tO\npotassium\tB-Chemical\nlevels\tO\nand\tO\nlower\tO\nbaseline\tO\npotassium\tB-Chemical\nsupplement\tO\ndoses\tO\n,\tO\nand\tO\nwere\tO\nmore\tO\nlikely\tO\nto\tO\nbe\tO\ntreated\tO\nwith\tO\nbeta\tO\n-\tO\nblockers\tO\nthan\tO\ncontrols\tO\n(\tO\nn\tO\n=\tO\n134\tO\n)\tO\n.\tO\n\nPatients\tO\nwho\tO\ndeveloped\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\nhad\tO\nlower\tO\nbaseline\tO\nbody\tO\nweight\tO\nand\tO\nhigher\tO\nbaseline\tO\nserum\tO\ncreatinine\tB-Chemical\n,\tO\nrequired\tO\nhigher\tO\ndoses\tO\nof\tO\nloop\tO\ndiuretics\tO\n,\tO\nand\tO\nwere\tO\nmore\tO\nlikely\tO\nto\tO\nbe\tO\ntreated\tO\nwith\tO\nthiazide\tB-Chemical\ndiuretics\tO\nthan\tO\ncontrols\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSpironolactone\tB-Chemical\n-\tO\ninduced\tO\nhyperkalemia\tB-Disease\nand\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\nare\tO\nmore\tO\ncommon\tO\nin\tO\nour\tO\nclinical\tO\nexperience\tO\nthan\tO\nreported\tO\npreviously\tO\n.\tO\n\nThis\tO\ndifference\tO\nis\tO\nexplained\tO\nby\tO\npatient\tO\ncomorbidities\tO\nand\tO\nmore\tO\nfrequent\tO\nuse\tO\nof\tO\nbeta\tO\n-\tO\nblockers\tO\n.\tO\n\nAcute\tO\nreserpine\tB-Chemical\nand\tO\nsubchronic\tO\nhaloperidol\tB-Chemical\ntreatments\tO\nchange\tO\nsynaptosomal\tO\nbrain\tO\nglutamate\tB-Chemical\nuptake\tO\nand\tO\nelicit\tO\norofacial\tB-Disease\ndyskinesia\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nReserpine\tB-Chemical\n-\tO\nand\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\norofacial\tB-Disease\ndyskinesia\tI-Disease\nare\tO\nputative\tO\nanimal\tO\nmodels\tO\nof\tO\ntardive\tB-Disease\ndyskinesia\tI-Disease\n(\tO\nTD\tB-Disease\n)\tO\nwhose\tO\npathophysiology\tO\nhas\tO\nbeen\tO\nrelated\tO\nto\tO\nfree\tO\nradical\tO\ngeneration\tO\nand\tO\noxidative\tO\nstress\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthe\tO\nauthors\tO\ninduced\tO\norofacial\tB-Disease\ndyskinesia\tI-Disease\nby\tO\nacute\tO\nreserpine\tB-Chemical\nand\tO\nsubchronic\tO\nhaloperidol\tB-Chemical\nadministration\tO\nto\tO\nrats\tO\n.\tO\n\nReserpine\tB-Chemical\ninjection\tO\n(\tO\none\tO\ndose\tO\nof\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nevery\tO\nother\tO\nday\tO\nfor\tO\n3\tO\ndays\tO\ncaused\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nvacuous\tO\nchewing\tO\n,\tO\ntongue\tO\nprotrusion\tO\nand\tO\nduration\tO\nof\tO\nfacial\tO\ntwitching\tO\n,\tO\ncompared\tO\nto\tO\nthe\tO\ncontrol\tO\n.\tO\n\nHaloperidol\tB-Chemical\nadministration\tO\n(\tO\none\tO\ndose\tO\nof\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nonce\tO\na\tO\nweek\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nfor\tO\n4\tO\nweeks\tO\ncaused\tO\nan\tO\nincrease\tO\nin\tO\nvacuous\tO\nchewing\tO\n,\tO\ntongue\tO\nprotrusion\tO\nand\tO\nduration\tO\nof\tO\nfacial\tO\ntwitching\tO\nobserved\tO\nin\tO\nfour\tO\nweekly\tO\nevaluations\tO\n.\tO\n\nAfter\tO\nthe\tO\ntreatments\tO\nand\tO\nbehavioral\tO\nobservation\tO\n,\tO\nglutamate\tB-Chemical\nuptake\tO\nby\tO\nsegments\tO\nof\tO\nthe\tO\nbrain\tO\nwas\tO\nanalyzed\tO\n.\tO\n\nA\tO\ndecreased\tO\nglutamate\tB-Chemical\nuptake\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\nsubcortical\tO\nparts\tO\nof\tO\nanimals\tO\ntreated\tO\nwith\tO\nreserpine\tB-Chemical\nand\tO\nhaloperidol\tB-Chemical\n,\tO\ncompared\tO\nto\tO\nthe\tO\ncontrol\tO\n.\tO\n\nImportantly\tO\n,\tO\na\tO\ndecrease\tO\nin\tO\nglutamate\tB-Chemical\nuptake\tO\ncorrelates\tO\nnegatively\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\nincidence\tO\nof\tO\norofacial\tB-Disease\ndiskinesia\tI-Disease\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nearly\tO\nchanges\tO\nin\tO\nglutamate\tB-Chemical\ntransport\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\nvacuous\tO\nchewing\tO\nmovements\tO\nin\tO\nrats\tO\n.\tO\n\nCeftriaxone\tB-Chemical\n-\tO\nassociated\tO\nbiliary\tB-Disease\npseudolithiasis\tI-Disease\nin\tO\npaediatric\tO\nsurgical\tO\npatients\tO\n.\tO\n\nIt\tO\nis\tO\nwell\tO\nknown\tO\nthat\tO\nceftriaxone\tB-Chemical\nleads\tO\nto\tO\npseudolithiasis\tB-Disease\nin\tO\nsome\tO\npatients\tO\n.\tO\n\nClinical\tO\nand\tO\nexperimental\tO\nstudies\tO\nalso\tO\nsuggest\tO\nthat\tO\nsituations\tO\ncausing\tO\ngallbladder\tB-Disease\ndysfunction\tI-Disease\n,\tO\nsuch\tO\nas\tO\nfasting\tO\n,\tO\nmay\tO\nhave\tO\na\tO\nrole\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\npseudolithiasis\tB-Disease\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\nprospectively\tO\nevaluated\tO\nthe\tO\nincidence\tO\nand\tO\nclinical\tO\nimportance\tO\nof\tO\npseudolithiasis\tB-Disease\nin\tO\npaediatric\tO\nsurgical\tO\npatients\tO\nreceiving\tO\nceftriaxone\tB-Chemical\ntreatment\tO\n,\tO\nwho\tO\noften\tO\nhad\tO\nto\tO\nfast\tO\nin\tO\nthe\tO\npost\tO\n-\tO\noperative\tO\nperiod\tO\n.\tO\n\nFifty\tO\nchildren\tO\nwho\tO\nwere\tO\ngiven\tO\nceftriaxone\tB-Chemical\nwere\tO\nevaluated\tO\nby\tO\nserial\tO\nabdominal\tO\nsonograms\tO\n.\tO\n\nOf\tO\nthose\tO\n,\tO\n13\tO\n(\tO\n26\tO\n%\tO\n)\tO\ndeveloped\tO\nbiliary\tO\npathology\tO\n.\tO\n\nComparison\tO\nof\tO\nthe\tO\npatients\tO\nwith\tO\nor\tO\nwithout\tO\npseudolithiasis\tB-Disease\nrevealed\tO\nno\tO\nsignificant\tO\ndifference\tO\nwith\tO\nrespect\tO\nto\tO\nage\tO\n,\tO\nsex\tO\n,\tO\nduration\tO\nof\tO\nthe\tO\ntreatment\tO\nand\tO\nstarvation\tO\nvariables\tO\n.\tO\n\nAfter\tO\ncessation\tO\nof\tO\nthe\tO\ntreatment\tO\n,\tO\npseudolithiasis\tB-Disease\nresolved\tO\nspontaneously\tO\nwithin\tO\na\tO\nshort\tO\nperiod\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\npseudolithiasis\tB-Disease\nis\tO\nnot\tO\naffected\tO\nby\tO\nfasting\tO\n.\tO\n\nCoronary\tB-Disease\naneurysm\tI-Disease\nafter\tO\nimplantation\tO\nof\tO\na\tO\npaclitaxel\tB-Chemical\n-\tO\neluting\tO\nstent\tO\n.\tO\n\nFormation\tO\nof\tO\ncoronary\tB-Disease\naneurysm\tI-Disease\nis\tO\na\tO\nrare\tO\ncomplication\tO\nof\tO\nstenting\tO\nwith\tO\nbare\tO\nmetal\tO\nstents\tO\n,\tO\nbut\tO\nbased\tO\non\tO\nexperimental\tO\nstudies\tO\ndrug\tO\n-\tO\neluting\tO\nstents\tO\nmay\tO\ninduce\tO\ntoxic\tO\neffects\tO\non\tO\nthe\tO\nvessel\tO\nwall\tO\nwith\tO\nincomplete\tO\nstent\tO\napposition\tO\n,\tO\naneurysm\tB-Disease\nformation\tO\nand\tO\nwith\tO\nthe\tO\npotential\tO\nof\tO\nstent\tO\nthrombosis\tB-Disease\nor\tO\nvessel\tB-Disease\nrupture\tI-Disease\n.\tO\n\nWe\tO\npresent\tO\na\tO\n43\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\ndeveloped\tO\na\tO\ncoronary\tB-Disease\naneurysm\tI-Disease\nin\tO\nthe\tO\nright\tO\ncoronary\tO\nartery\tO\n6\tO\nmonths\tO\nafter\tO\nreceiving\tO\na\tO\npaclitaxel\tB-Chemical\n-\tO\neluting\tO\nstent\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nasymptomatic\tO\nand\tO\nthe\tO\naneurysm\tB-Disease\nwas\tO\ndetected\tO\nin\tO\na\tO\nroutine\tO\ncontrol\tO\n.\tO\n\nAngiography\tO\nand\tO\nintracoronary\tO\nultrasound\tO\ndemonstrated\tO\nlack\tO\nof\tO\ncontact\tO\nbetween\tO\nstent\tO\nand\tO\nvessel\tO\nwall\tO\nin\tO\na\tO\n15\tO\n-\tO\nmm\tO\nlong\tO\nsegment\tO\nwith\tO\nmaximal\tO\naneurysm\tB-Disease\ndiameter\tO\nof\tO\n6\tO\n.\tO\n0\tO\nmm\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nsuccessfully\tO\ntreated\tO\nwith\tO\na\tO\ngraft\tO\nstent\tO\n.\tO\n\nCauses\tO\nof\tO\nacute\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nin\tO\npatients\tO\nreceiving\tO\nkidney\tO\ntransplantation\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nis\tO\na\tO\nwell\tO\n-\tO\nknown\tO\nproblem\tO\nin\tO\npatients\tO\nfollowing\tO\nrenal\tO\ntransplantation\tO\n.\tO\n\nIn\tO\npostrenal\tO\ntransplantation\tO\n,\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nis\tO\noften\tO\na\tO\nreflection\tO\nof\tO\nhemolytic\tB-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nWe\tO\naimed\tO\nto\tO\ndetermine\tO\nthe\tO\ncauses\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nin\tO\na\tO\npopulation\tO\nof\tO\nrenal\tO\ntransplantation\tO\nrecipients\tO\nand\tO\ndiscuss\tO\nthe\tO\nliterature\tO\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nWe\tO\ninvestigated\tO\nthe\tO\ncauses\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nduring\tO\na\tO\n1\tO\n-\tO\nyear\tO\nperiod\tO\n,\tO\nfrom\tO\nJune\tO\n2003\tO\nto\tO\nJune\tO\n2004\tO\n,\tO\nat\tO\nthe\tO\nKing\tO\nFahad\tO\nNational\tO\nGuard\tO\nHospital\tO\nin\tO\nRiyadh\tO\n,\tO\nSaudi\tO\nArabia\tO\n,\tO\nby\tO\nreviewing\tO\nthe\tO\nslides\tO\nof\tO\nall\tO\ntransplant\tO\nbiopsies\tO\n(\tO\nn\tO\n=\tO\n25\tO\n)\tO\nperformed\tO\nduring\tO\nthis\tO\ninterval\tO\n.\tO\n\nPre\tO\n-\tO\nand\tO\nposttransplant\tO\ncrossmatching\tO\nwas\tO\ndone\tO\nwhen\tO\npossible\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFive\tO\ncases\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nwere\tO\nfound\tO\n.\tO\n\nThree\tO\nof\tO\nthese\tO\ncases\tO\nwere\tO\nfrom\tO\nthe\tO\n25\tO\ntransplantations\tO\nperformed\tO\nat\tO\nKing\tO\nFahad\tO\nNational\tO\nGuard\tO\nHospital\tO\n,\tO\nwhile\tO\nthe\tO\nother\tO\n2\tO\ntransplantations\tO\nhad\tO\nbeen\tO\nperformed\tO\nabroad\tO\nand\tO\nwere\tO\nreferred\tO\nto\tO\nus\tO\nfor\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nThree\tO\ncases\tO\nwere\tO\nrelated\tO\nto\tO\ncyclosporine\tB-Chemical\n,\tO\nand\tO\n1\tO\ncase\tO\nwas\tO\nsecondary\tO\nto\tO\nboth\tO\ncyclosporine\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\n.\tO\n\nThe\tO\nfifth\tO\ncase\tO\nhad\tO\nfeatures\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nrelated\tO\nto\tO\nan\tO\nantiphospholipid\tB-Disease\nsyndrome\tI-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\nsystemic\tB-Disease\nlupus\tI-Disease\nerythematosus\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIn\tO\nthe\tO\nliterature\tO\n,\tO\nthe\tO\nmost\tO\n-\tO\nfrequent\tO\ncause\tO\nof\tO\nhemolytic\tB-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\nin\tO\npatients\tO\nfollowing\tO\nrenal\tO\ntransplantation\tO\nis\tO\nrecurrence\tO\nof\tO\nthe\tO\nhemolytic\tB-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nOther\tO\ncauses\tO\ninclude\tO\ndrug\tO\n-\tO\nrelated\tO\n(\tO\ncyclosporine\tB-Chemical\n,\tO\ntacrolimus\tB-Chemical\n)\tO\ntoxicity\tB-Disease\n,\tO\nprocoagulant\tO\nstatus\tO\n,\tO\nand\tO\nantibody\tO\n-\tO\nmediated\tO\nrejection\tO\n.\tO\n\nWe\tO\nfound\tO\nthat\tO\nthe\tO\nmost\tO\n-\tO\nfrequent\tO\ncause\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nwas\tO\ndrug\tO\nrelated\tO\n,\tO\nsecondary\tO\nmainly\tO\nto\tO\ncyclosporine\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\n,\tO\nthe\tO\nfrequency\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nwas\tO\nsimilar\tO\nto\tO\nthe\tO\npercentage\tO\nreported\tO\nin\tO\nthe\tO\nliterature\tO\n(\tO\n20\tO\n%\tO\n)\tO\n.\tO\n\nComparison\tO\nof\tO\ndevelopmental\tO\ntoxicity\tB-Disease\nof\tO\nselective\tO\nand\tO\nnon\tO\n-\tO\nselective\tO\ncyclooxygenase\tO\n-\tO\n2\tO\ninhibitors\tO\nin\tO\nCRL\tO\n:\tO\n(\tO\nWI\tO\n)\tO\nWUBR\tO\nWistar\tO\nrats\tO\n-\tO\n-\tO\nDFU\tB-Chemical\nand\tO\npiroxicam\tB-Chemical\nstudy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyclooxygenase\tO\n(\tO\nCOX\tO\n)\tO\ninhibitors\tO\nare\tO\none\tO\nof\tO\nthe\tO\nmost\tO\noften\tO\ningested\tO\ndrugs\tO\nduring\tO\npregnancy\tO\n.\tO\n\nUnlike\tO\ngeneral\tO\ntoxicity\tB-Disease\ndata\tO\n,\tO\ntheir\tO\nprenatal\tO\ntoxic\tO\neffects\tO\nwere\tO\nnot\tO\nextensively\tO\nstudied\tO\nbefore\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\nexperiment\tO\nwas\tO\nto\tO\nevaluate\tO\nthe\tO\ndevelopmental\tO\ntoxicity\tB-Disease\nof\tO\nthe\tO\nnon\tO\n-\tO\nselective\tO\n(\tO\npiroxicam\tB-Chemical\n)\tO\nand\tO\nselective\tO\n(\tO\nDFU\tB-Chemical\n;\tO\n5\tB-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\ndimethyl\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nfluorophenyl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethylsulphonyl\tI-Chemical\n)\tI-Chemical\nphenyl\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n(\tI-Chemical\n5H\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nfuranon\tI-Chemical\n)\tO\nCOX\tO\n-\tO\n2\tO\ninhibitors\tO\n.\tO\n\nMETHODS\tO\n:\tO\nDrugs\tO\nwere\tO\nseparately\tO\n,\tO\norally\tO\nonce\tO\ndaily\tO\ndosed\tO\nto\tO\npregnant\tO\nrats\tO\nfrom\tO\nday\tO\n8\tO\nto\tO\n21\tO\n(\tO\nGD1\tO\n=\tO\nplug\tO\nday\tO\n)\tO\n.\tO\n\nDoses\tO\nwere\tO\nset\tO\nat\tO\n0\tO\n.\tO\n3\tO\n,\tO\n3\tO\n.\tO\n0\tO\nand\tO\n30\tO\n.\tO\n0mg\tO\n/\tO\nkg\tO\nfor\tO\npiroxicam\tB-Chemical\nand\tO\n0\tO\n.\tO\n2\tO\n,\tO\n2\tO\n.\tO\n0\tO\nand\tO\n20\tO\n.\tO\n0mg\tO\n/\tO\nkg\tO\nfor\tO\nDFU\tB-Chemical\n.\tO\n\nFetuses\tO\nwere\tO\ndelivered\tO\non\tO\nGD\tO\n21\tO\nand\tO\nroutinely\tO\nexamined\tO\n.\tO\n\nComprehensive\tO\nclinical\tO\nand\tO\ndevelopmental\tO\nmeasurements\tO\nwere\tO\ndone\tO\n.\tO\n\nThe\tO\npooled\tO\nstatistical\tO\nanalysis\tO\nfor\tO\nventricular\tB-Disease\nseptal\tI-Disease\n(\tI-Disease\nVSD\tI-Disease\n)\tI-Disease\nand\tI-Disease\nmidline\tI-Disease\n(\tI-Disease\nMD\tI-Disease\n)\tI-Disease\ndefects\tI-Disease\nwas\tO\nperformed\tO\nfor\tO\nrat\tO\nfetuses\tO\nexposed\tO\nto\tO\npiroxicam\tB-Chemical\n,\tO\nselective\tO\nand\tO\nnon\tO\n-\tO\nselective\tO\nCOX\tO\n-\tO\n2\tO\ninhibitor\tO\nbased\tO\non\tO\npresent\tO\nand\tO\nhistoric\tO\ndata\tO\n.\tO\n\nRESULTS\tO\n:\tO\nMaternal\tO\ntoxicity\tB-Disease\n,\tO\nintrauterine\tB-Disease\ngrowth\tI-Disease\nretardation\tI-Disease\n,\tO\nand\tO\nincrease\tB-Disease\nof\tI-Disease\nexternal\tI-Disease\nand\tI-Disease\nskeletal\tI-Disease\nvariations\tI-Disease\nwere\tO\nfound\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\nthe\tO\nhighest\tO\ndose\tO\nof\tO\npiroxicam\tB-Chemical\n.\tO\n\nDecrease\tO\nof\tO\nfetal\tO\nlength\tO\nwas\tO\nthe\tO\nonly\tO\nsigns\tO\nof\tO\nthe\tO\nDFU\tB-Chemical\ndevelopmental\tO\ntoxicity\tB-Disease\nobserved\tO\nin\tO\npups\tO\nexposed\tO\nto\tO\nthe\tO\nhighest\tO\ncompound\tO\ndose\tO\n.\tO\n\nLack\tO\nof\tO\nteratogenicity\tO\nwas\tO\nfound\tO\nin\tO\npiroxicam\tB-Chemical\nand\tO\nDFU\tB-Chemical\n-\tO\nexposed\tO\ngroups\tO\n.\tO\n\nPrenatal\tO\nexposure\tO\nto\tO\nnon\tO\n-\tO\nselective\tO\nCOX\tO\ninhibitors\tO\nincreases\tO\nthe\tO\nrisk\tO\nof\tO\nVSD\tO\nand\tO\nMD\tO\nwhen\tO\ncompared\tO\nto\tO\nhistoric\tO\ncontrol\tO\nbut\tO\nnot\tO\nwith\tO\nselective\tO\nCOX\tO\n-\tO\n2\tO\ninhibitors\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nBoth\tO\nselective\tO\nand\tO\nnon\tO\n-\tO\nselective\tO\nCOX\tO\n-\tO\n2\tO\ninhibitors\tO\nwere\tO\ntoxic\tO\nfor\tO\nrats\tO\nfetuses\tO\nwhen\tO\nadministered\tO\nin\tO\nthe\tO\nhighest\tO\ndose\tO\n.\tO\n\nUnlike\tO\nDFU\tB-Chemical\n,\tO\npiroxicam\tB-Chemical\nwas\tO\nalso\tO\nhighly\tO\ntoxic\tO\nto\tO\nthe\tO\ndams\tO\n.\tO\n\nPrenatal\tO\nexposure\tO\nto\tO\nselective\tO\nCOX\tO\n-\tO\n2\tO\ninhibitors\tO\ndoes\tO\nnot\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nventricular\tB-Disease\nseptal\tI-Disease\nand\tI-Disease\nmidline\tI-Disease\ndefects\tI-Disease\nin\tO\nrat\tO\nwhen\tO\ncompared\tO\nto\tO\nnon\tO\n-\tO\nselective\tO\ndrugs\tO\nand\tO\nhistoric\tO\ncontrol\tO\n.\tO\n\nLone\tO\natrial\tB-Disease\nfibrillation\tI-Disease\nassociated\tO\nwith\tO\ncreatine\tB-Chemical\nmonohydrate\tO\nsupplementation\tO\n.\tO\n\nAtrial\tB-Disease\nfibrillation\tI-Disease\nin\tO\nyoung\tO\npatients\tO\nwithout\tO\nstructural\tO\nheart\tB-Disease\ndisease\tI-Disease\nis\tO\nrare\tO\n.\tO\n\nTherefore\tO\n,\tO\nwhen\tO\nthe\tO\narrhythmia\tB-Disease\nis\tO\npresent\tO\nin\tO\nthis\tO\npopulation\tO\n,\tO\nreversible\tO\ncauses\tO\nmust\tO\nbe\tO\nidentified\tO\nand\tO\nresolved\tO\n.\tO\n\nThyroid\tB-Disease\ndisorders\tI-Disease\n,\tO\nillicit\tO\ndrug\tO\nor\tO\nstimulant\tO\nuse\tO\n,\tO\nand\tO\nacute\tB-Disease\nalcohol\tI-Disease\nintoxication\tI-Disease\nare\tO\namong\tO\nthese\tO\ncauses\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n30\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nCaucasian\tO\nman\tO\nwho\tO\ncame\tO\nto\tO\nthe\tO\nemergency\tO\ndepartment\tO\nin\tO\natrial\tB-Disease\nfibrillation\tI-Disease\nwith\tO\nrapid\tO\nventricular\tO\nresponse\tO\n.\tO\n\nHis\tO\nmedical\tO\nhistory\tO\nwas\tO\nunremarkable\tO\n,\tO\nexcept\tO\nfor\tO\nminor\tO\nfractures\tB-Disease\nof\tO\nthe\tO\nfingers\tO\nand\tO\nfoot\tO\n.\tO\n\nThyroid\tO\n-\tO\nstimulating\tO\nhormone\tO\n,\tO\nmagnesium\tB-Chemical\n,\tO\nand\tO\npotassium\tB-Chemical\nlevels\tO\nwere\tO\nwithin\tO\nnormal\tO\nlimits\tO\n,\tO\nurine\tO\ndrug\tO\nscreen\tO\nwas\tO\nnegative\tO\n,\tO\nand\tO\nalcohol\tB-Chemical\nuse\tO\nwas\tO\ndenied\tO\n.\tO\n\nHowever\tO\n,\tO\nwhen\tO\nthe\tO\npatient\tO\nwas\tO\nquestioned\tO\nabout\tO\nuse\tO\nof\tO\nherbal\tO\nproducts\tO\nand\tO\nsupplements\tO\n,\tO\nthe\tO\nuse\tO\nof\tO\ncreatine\tB-Chemical\nmonohydrate\tO\nwas\tO\nrevealed\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nadmitted\tO\nto\tO\nthe\tO\nhospital\tO\n,\tO\nanticoagulated\tO\nwith\tO\nunfractionated\tO\nheparin\tB-Chemical\n,\tO\nand\tO\ngiven\tO\nintravenous\tO\ndiltiazem\tB-Chemical\nfor\tO\nrate\tO\ncontrol\tO\nand\tO\nintravenous\tO\namiodarone\tB-Chemical\nfor\tO\nrate\tO\nand\tO\nrhythm\tO\ncontrol\tO\n.\tO\n\nWhen\tO\ndischarged\tO\nless\tO\nthan\tO\n24\tO\nhours\tO\nlater\tO\n,\tO\nhe\tO\nwas\tO\nreceiving\tO\nmetoprolol\tB-Chemical\nand\tO\naspirin\tB-Chemical\n,\tO\nwith\tO\nfollow\tO\n-\tO\nup\tO\nplans\tO\nfor\tO\nechocardiography\tO\nand\tO\nnuclear\tO\nimaging\tO\nto\tO\nassess\tO\nperfusion\tO\n.\tO\n\nExogenous\tO\ncreatine\tB-Chemical\nis\tO\nused\tO\nby\tO\nathletes\tO\nto\tO\ntheoretically\tO\nimprove\tO\nexercise\tO\nperformance\tO\n.\tO\n\nVegetarians\tO\nmay\tO\nalso\tO\ntake\tO\ncreatine\tB-Chemical\nto\tO\nreplace\tO\nwhat\tO\nthey\tO\nare\tO\nnot\tO\nconsuming\tO\nfrom\tO\nmeat\tO\n,\tO\nfish\tO\n,\tO\nand\tO\nother\tO\nanimal\tO\nproducts\tO\n.\tO\n\nPrevious\tO\nanecdotal\tO\nreports\tO\nhave\tO\nlinked\tO\ncreatine\tB-Chemical\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\narrhythmia\tB-Disease\n.\tO\n\nClinicians\tO\nmust\tO\nbe\tO\ndiligent\tO\nwhen\tO\ninterviewing\tO\npatients\tO\nabout\tO\ntheir\tO\ndrug\tO\ntherapy\tO\nhistories\tO\nand\tO\ninclude\tO\nquestions\tO\nabout\tO\ntheir\tO\nuse\tO\nof\tO\nherbal\tO\nproducts\tO\nand\tO\ndietary\tO\nsupplements\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nit\tO\nis\tO\nimportant\tO\nto\tO\nreport\tO\nadverse\tO\neffects\tO\nassociated\tO\nwith\tO\nfrequently\tO\nconsumed\tO\nsupplements\tO\nand\tO\nherbal\tO\nproducts\tO\nto\tO\nthe\tO\nFood\tO\nand\tO\nDrug\tO\nAdministration\tO\nand\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nSeizures\tB-Disease\ninduced\tO\nby\tO\nthe\tO\ncocaine\tB-Chemical\nmetabolite\tO\nbenzoylecgonine\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nhalf\tO\n-\tO\nlife\tO\n(\tO\nt1\tO\n/\tO\n2\tO\n)\tO\nof\tO\ncocaine\tB-Chemical\nis\tO\nrelatively\tO\nshort\tO\n,\tO\nbut\tO\nsome\tO\nof\tO\nthe\tO\nconsequences\tO\nof\tO\nits\tO\nuse\tO\n,\tO\nsuch\tO\nas\tO\nseizures\tB-Disease\nand\tO\nstrokes\tB-Disease\n,\tO\ncan\tO\noccur\tO\nhours\tO\nafter\tO\nexposure\tO\n.\tO\n\nThis\tO\nled\tO\nus\tO\nto\tO\nhypothesize\tO\nthat\tO\na\tO\nmetabolite\tO\nof\tO\ncocaine\tB-Chemical\nmay\tO\nbe\tO\nresponsible\tO\nfor\tO\nsome\tO\nof\tO\nthose\tO\ndelayed\tO\nsequelae\tO\n.\tO\n\nWe\tO\nevaluated\tO\nthe\tO\npotential\tO\nof\tO\nthe\tO\nmajor\tO\nmetabolite\tO\nof\tO\ncocaine\tB-Chemical\n,\tO\nbenzoylecgonine\tB-Chemical\n(\tO\nBE\tB-Chemical\n)\tO\n,\tO\nto\tO\ncause\tO\nseizures\tB-Disease\n.\tO\n\nTwo\tO\nseparate\tO\nequimolar\tO\ndoses\tO\n(\tO\n0\tO\n.\tO\n2\tO\nand\tO\n0\tO\n.\tO\n4\tO\nmumol\tO\n)\tO\nof\tO\neither\tO\ncocaine\tB-Chemical\nor\tO\nBE\tB-Chemical\nwere\tO\ninjected\tO\nventricularly\tO\nin\tO\nunanesthetized\tO\njuvenile\tO\nrats\tO\n.\tO\n\nTreated\tO\nrats\tO\nwere\tO\nthen\tO\nevaluated\tO\nfor\tO\nincidence\tO\n,\tO\nlatency\tO\n,\tO\nand\tO\nseizure\tB-Disease\npattern\tO\nor\tO\nfor\tO\nlocomotor\tO\nactivity\tO\nin\tO\nanimals\tO\nwithout\tO\nseizures\tB-Disease\n.\tO\n\nBE\tB-Chemical\n-\tO\nInduced\tO\nseizures\tB-Disease\noccurred\tO\nmore\tO\nfrequently\tO\nand\tO\nhad\tO\nsignificantly\tO\nlonger\tO\nlatencies\tO\nthan\tO\nthose\tO\ninduced\tO\nby\tO\nequimolar\tO\namounts\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nWhereas\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nwere\tO\nbest\tO\ncharacterized\tO\nas\tO\nbrief\tO\n,\tO\ngeneralized\tO\n,\tO\nand\tO\ntonic\tO\nand\tO\nresulted\tO\nin\tO\ndeath\tB-Disease\n,\tO\nthose\tO\ninduced\tO\nby\tO\nBE\tB-Chemical\nwere\tO\nprolonged\tO\n,\tO\noften\tO\nmultiple\tO\nand\tO\nmixed\tO\nin\tO\ntype\tO\n,\tO\nand\tO\nrarely\tO\nresulted\tO\nin\tO\ndeath\tB-Disease\n.\tO\n\nElectrical\tO\nrecordings\tO\nfrom\tO\nthe\tO\nhippocampus\tO\nshowed\tO\na\tO\nrhythmic\tO\nprogression\tO\nin\tO\nEEG\tO\nfrequency\tO\nand\tO\nvoltage\tO\nwith\tO\nclinical\tO\nseizure\tB-Disease\nexpression\tO\n.\tO\n\nBE\tB-Chemical\n-\tO\nInjected\tO\nrats\tO\nthat\tO\ndid\tO\nnot\tO\nhave\tO\nseizures\tB-Disease\nhad\tO\nsignificantly\tO\nmore\tO\nlocomotor\tO\nactivity\tO\nthan\tO\ncocaine\tB-Chemical\n-\tO\ninjected\tO\nanimals\tO\nwithout\tO\nseizures\tB-Disease\n.\tO\n\nThe\tO\nfinding\tO\nthat\tO\ncocaine\tB-Chemical\n-\tO\nand\tO\nBE\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\ndiffer\tO\nin\tO\nseveral\tO\nrespects\tO\nsuggests\tO\nmore\tO\nthan\tO\none\tO\nmechanism\tO\nfor\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nemphasizes\tO\nthe\tO\nimportance\tO\nof\tO\na\tO\ncocaine\tB-Chemical\nmetabolite\tO\n,\tO\nBE\tB-Chemical\n.\tO\n\nThe\tO\nselective\tO\n5\tO\n-\tO\nHT6\tO\nreceptor\tO\nantagonist\tO\nRo4368554\tB-Chemical\nrestores\tO\nmemory\tO\nperformance\tO\nin\tO\ncholinergic\tO\nand\tO\nserotonergic\tO\nmodels\tO\nof\tO\nmemory\tB-Disease\ndeficiency\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nAntagonists\tO\nat\tO\nserotonin\tB-Chemical\ntype\tO\n6\tO\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n(\tO\n6\tO\n)\tO\n)\tO\nreceptors\tO\nshow\tO\nactivity\tO\nin\tO\nmodels\tO\nof\tO\nlearning\tO\nand\tO\nmemory\tO\n.\tO\n\nAlthough\tO\nthe\tO\nunderlying\tO\nmechanism\tO\n(\tO\ns\tO\n)\tO\nare\tO\nnot\tO\nwell\tO\nunderstood\tO\n,\tO\nthese\tO\neffects\tO\nmay\tO\ninvolve\tO\nan\tO\nincrease\tO\nin\tO\nacetylcholine\tB-Chemical\n(\tO\nACh\tB-Chemical\n)\tO\nlevels\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nsought\tO\nto\tO\ncharacterize\tO\nthe\tO\ncognitive\tO\n-\tO\nenhancing\tO\neffects\tO\nof\tO\nthe\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n(\tO\n6\tO\n)\tO\nantagonist\tO\nRo4368554\tB-Chemical\n(\tO\n3\tB-Chemical\n-\tI-Chemical\nbenzenesulfonyl\tI-Chemical\n-\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\npiperazin\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nyl\tI-Chemical\n)\tI-Chemical\n1H\tI-Chemical\n-\tI-Chemical\nindole\tI-Chemical\n)\tO\nin\tO\na\tO\nrat\tO\nobject\tO\nrecognition\tO\ntask\tO\nemploying\tO\na\tO\ncholinergic\tO\n(\tO\nscopolamine\tB-Chemical\npretreatment\tO\n)\tO\nand\tO\na\tO\nserotonergic\tO\n-\tO\n(\tO\ntryptophan\tB-Chemical\n(\tO\nTRP\tB-Chemical\n)\tO\ndepletion\tO\n)\tO\ndeficient\tO\nmodel\tO\n,\tO\nand\tO\ncompared\tO\nits\tO\npattern\tO\nof\tO\naction\tO\nwith\tO\nthat\tO\nof\tO\nthe\tO\nacetylcholinesterase\tO\ninhibitor\tO\nmetrifonate\tB-Chemical\n.\tO\n\nInitial\tO\ntesting\tO\nin\tO\na\tO\ntime\tO\n-\tO\ndependent\tO\nforgetting\tO\ntask\tO\nemploying\tO\na\tO\n24\tO\n-\tO\nh\tO\ndelay\tO\nbetween\tO\ntraining\tO\nand\tO\ntesting\tO\nshowed\tO\nthat\tO\nmetrifonate\tB-Chemical\nimproved\tO\nobject\tO\nrecognition\tO\n(\tO\nat\tO\n10\tO\nand\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\n,\tO\nwhereas\tO\nRo4368554\tB-Chemical\nwas\tO\ninactive\tO\n.\tO\n\nBoth\tO\n,\tO\nRo4368554\tB-Chemical\n(\tO\n3\tO\nand\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nintraperitoneally\tO\n(\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n)\tO\nand\tO\nmetrifonate\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n,\tO\nrespectively\tO\n)\tO\nreversed\tO\nmemory\tB-Disease\ndeficits\tI-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\nand\tO\nTRP\tB-Chemical\ndepletion\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\nand\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nalthough\tO\nRo4368554\tB-Chemical\ndid\tO\nnot\tO\nimprove\tO\na\tO\ntime\tO\n-\tO\nrelated\tO\nretention\tO\ndeficit\tO\n,\tO\nit\tO\nreversed\tO\na\tO\ncholinergic\tO\nand\tO\na\tO\nserotonergic\tO\nmemory\tB-Disease\ndeficit\tI-Disease\n,\tO\nsuggesting\tO\nthat\tO\nboth\tO\nmechanisms\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\nfacilitation\tO\nof\tO\nobject\tO\nmemory\tO\nby\tO\nRo4368554\tB-Chemical\nand\tO\n,\tO\npossibly\tO\n,\tO\nother\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n(\tO\n6\tO\n)\tO\nreceptor\tO\nantagonists\tO\n.\tO\n\nEvaluation\tO\nof\tO\nthe\tO\nanticocaine\tO\nmonoclonal\tO\nantibody\tO\nGNC92H2\tB-Chemical\nas\tO\nan\tO\nimmunotherapy\tO\nfor\tO\ncocaine\tB-Disease\noverdose\tI-Disease\n.\tO\n\nThe\tO\nillicit\tO\nuse\tO\nof\tO\ncocaine\tB-Chemical\ncontinues\tO\nin\tO\nepidemic\tO\nproportions\tO\nand\tO\ntreatment\tO\nfor\tO\ncocaine\tB-Disease\noverdose\tI-Disease\nremains\tO\nelusive\tO\n.\tO\n\nCurrent\tO\nprotein\tO\n-\tO\nbased\tO\ntechnology\tO\noffers\tO\na\tO\nnew\tO\ntherapeutic\tO\nvenue\tO\nby\tO\nwhich\tO\nantibodies\tO\nbind\tO\nthe\tO\ndrug\tO\nin\tO\nthe\tO\nblood\tO\nstream\tO\n,\tO\ninactivating\tO\nits\tO\ntoxic\tO\neffects\tO\n.\tO\n\nThe\tO\ntherapeutic\tO\npotential\tO\nof\tO\nthe\tO\nanticocaine\tO\nantibody\tO\nGNC92H2\tB-Chemical\nwas\tO\nexamined\tO\nusing\tO\na\tO\nmodel\tO\nof\tO\ncocaine\tB-Disease\noverdose\tI-Disease\n.\tO\n\nSwiss\tO\nalbino\tO\nmice\tO\nprepared\tO\nwith\tO\nintrajugular\tO\ncatheters\tO\nwere\tO\ntested\tO\nin\tO\nphotocell\tO\ncages\tO\nafter\tO\nadministration\tO\nof\tO\n93\tO\nmg\tO\n/\tO\nkg\tO\n(\tO\nLD50\tO\n)\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\nGNC92H2\tB-Chemical\ninfusions\tO\nranging\tO\nfrom\tO\n30\tO\nto\tO\n190\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nGNC92H2\tB-Chemical\nwas\tO\ndelivered\tO\n30\tO\nmin\tO\nbefore\tO\n,\tO\nconcomitantly\tO\nor\tO\n3\tO\nmin\tO\nafter\tO\ncocaine\tB-Chemical\ntreatment\tO\n.\tO\n\nSignificant\tO\nblockade\tO\nof\tO\ncocaine\tB-Chemical\ntoxicity\tB-Disease\nwas\tO\nobserved\tO\nwith\tO\nthe\tO\nhigher\tO\ndose\tO\nof\tO\nGNC92H2\tB-Chemical\n(\tO\n190\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nwhere\tO\npremorbid\tO\nbehaviors\tO\nwere\tO\nreduced\tO\nup\tO\nto\tO\n40\tO\n%\tO\n,\tO\nseizures\tB-Disease\nup\tO\nto\tO\n77\tO\n%\tO\nand\tO\ndeath\tB-Disease\nby\tO\n72\tO\n%\tO\n.\tO\n\nImportantly\tO\n,\tO\nGNC92H2\tB-Chemical\nprevented\tO\ndeath\tB-Disease\neven\tO\npost\tO\n-\tO\ncocaine\tB-Chemical\ninjection\tO\n.\tO\n\nThe\tO\nresults\tO\nsupport\tO\nthe\tO\nimportant\tO\npotential\tO\nof\tO\nGNC92H2\tB-Chemical\nas\tO\na\tO\ntherapeutic\tO\ntool\tO\nagainst\tO\ncocaine\tB-Disease\noverdose\tI-Disease\n.\tO\n\nElectrocardiographic\tO\nevidence\tO\nof\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\nin\tO\npsychiatrically\tO\nhospitalized\tO\ncocaine\tB-Chemical\nabusers\tO\n.\tO\n\nThe\tO\nelectrocardiograms\tO\n(\tO\nECG\tO\n)\tO\nof\tO\n99\tO\ncocaine\tB-Chemical\n-\tO\nabusing\tO\npatients\tO\nwere\tO\ncompared\tO\nwith\tO\nthe\tO\nECGs\tO\nof\tO\n50\tO\nschizophrenic\tB-Disease\ncontrols\tO\n.\tO\n\nEleven\tO\nof\tO\nthe\tO\ncocaine\tB-Chemical\nabusers\tO\nand\tO\nnone\tO\nof\tO\nthe\tO\ncontrols\tO\nhad\tO\nECG\tO\nevidence\tO\nof\tO\nsignificant\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\ndefined\tO\nas\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n,\tO\nischemia\tB-Disease\n,\tO\nand\tO\nbundle\tB-Disease\nbranch\tI-Disease\nblock\tI-Disease\n.\tO\n\nBehavioral\tO\neffects\tO\nof\tO\nurotensin\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\ncentrally\tO\nadministered\tO\nin\tO\nmice\tO\n.\tO\n\nUrotensin\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\n(\tO\nU\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\n)\tO\nreceptors\tO\nare\tO\nwidely\tO\ndistributed\tO\nin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nIntracerebroventricular\tO\n(\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\ninjection\tO\nof\tO\nU\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\ncauses\tO\nhypertension\tB-Disease\nand\tO\nbradycardia\tB-Disease\nand\tO\nstimulates\tO\nprolactin\tO\nand\tO\nthyrotropin\tO\nsecretion\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nbehavioral\tO\neffects\tO\nof\tO\ncentrally\tO\nadministered\tO\nU\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\nhave\tO\nreceived\tO\nlittle\tO\nattention\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nwe\tO\ntested\tO\nthe\tO\neffects\tO\nof\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\ninjections\tO\nof\tO\nU\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\non\tO\nbehavioral\tO\n,\tO\nmetabolic\tO\n,\tO\nand\tO\nendocrine\tO\nresponses\tO\nin\tO\nmice\tO\n.\tO\n\nAdministration\tO\nof\tO\ngraded\tO\ndoses\tO\nof\tO\nU\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\n(\tO\n1\tO\n-\tO\n10\tO\n,\tO\n000\tO\nng\tO\n/\tO\nmouse\tO\n)\tO\nprovoked\tO\n:\tO\n(\tO\n1\tO\n)\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nreduction\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nhead\tO\ndips\tO\nin\tO\nthe\tO\nhole\tO\n-\tO\nboard\tO\ntest\tO\n;\tO\n(\tO\n2\tO\n)\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nreduction\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nentries\tO\nin\tO\nthe\tO\nwhite\tO\nchamber\tO\nin\tO\nthe\tO\nblack\tO\n-\tO\nand\tO\n-\tO\nwhite\tO\ncompartment\tO\ntest\tO\n,\tO\nand\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\nentries\tO\nin\tO\nthe\tO\ncentral\tO\nplatform\tO\nand\tO\nopen\tO\narms\tO\nin\tO\nthe\tO\nplus\tO\n-\tO\nmaze\tO\ntest\tO\n;\tO\nand\tO\n(\tO\n3\tO\n)\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nincrease\tO\nin\tO\nthe\tO\nduration\tO\nof\tO\nimmobility\tO\nin\tO\nthe\tO\nforced\tO\n-\tO\nswimming\tO\ntest\tO\nand\tO\ntail\tO\nsuspension\tO\ntest\tO\n.\tO\n\nIntracerebroventricular\tO\ninjection\tO\nof\tO\nU\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\nalso\tO\ncaused\tO\nan\tO\nincrease\tO\nin\tO\n:\tO\nfood\tO\nintake\tO\nat\tO\ndoses\tO\nof\tO\n100\tO\nand\tO\n1\tO\n,\tO\n000\tO\nng\tO\n/\tO\nmouse\tO\n,\tO\nwater\tO\nintake\tO\nat\tO\ndoses\tO\nof\tO\n100\tO\n-\tO\n10\tO\n,\tO\n000\tO\nng\tO\n/\tO\nmouse\tO\n,\tO\nand\tO\nhorizontal\tO\nlocomotion\tO\nactivity\tO\nat\tO\na\tO\ndose\tO\nof\tO\n10\tO\n,\tO\n000\tO\nng\tO\n/\tO\nmouse\tO\n.\tO\n\nWhatever\tO\nwas\tO\nthe\tO\ndose\tO\n,\tO\nthe\tO\ncentral\tO\nadministration\tO\nof\tO\nU\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\nhad\tO\nno\tO\neffect\tO\non\tO\nbody\tO\ntemperature\tO\n,\tO\nnociception\tO\n,\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\npenile\tB-Disease\nerection\tI-Disease\nand\tO\nclimbing\tO\nbehavior\tO\n,\tO\nand\tO\nstress\tO\n-\tO\ninduced\tO\nplasma\tO\ncorticosterone\tB-Chemical\nlevel\tO\n.\tO\n\nTaken\tO\ntogether\tO\n,\tO\nthe\tO\npresent\tO\nstudy\tO\ndemonstrates\tO\nthat\tO\nthe\tO\ncentral\tO\ninjection\tO\nof\tO\nU\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\nat\tO\ndoses\tO\nof\tO\n1\tO\n-\tO\n10\tO\n,\tO\n000\tO\nng\tO\n/\tO\nmouse\tO\ninduces\tO\nanxiogenic\tO\n-\tO\nand\tO\ndepressant\tO\n-\tO\nlike\tO\neffects\tO\nin\tO\nmouse\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\nU\tB-Chemical\n-\tI-Chemical\nII\tI-Chemical\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nsome\tO\naspects\tO\nof\tO\npsychiatric\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nLearning\tO\nof\tO\nrats\tO\nunder\tO\namnesia\tB-Disease\ncaused\tO\nby\tO\npentobarbital\tB-Chemical\n.\tO\n\nDissociated\tO\nlearning\tO\nof\tO\nrats\tO\nin\tO\nthe\tO\nnormal\tO\nstate\tO\nand\tO\nthe\tO\nstate\tO\nof\tO\namnesia\tB-Disease\nproduced\tO\nby\tO\npentobarbital\tB-Chemical\n(\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\nip\tO\n)\tO\nwas\tO\ncarried\tO\nout\tO\n.\tO\n\nRats\tO\nwere\tO\ntrained\tO\nto\tO\napproach\tO\na\tO\nshelf\tO\nwhere\tO\nthey\tO\nreceived\tO\nfood\tO\nreinforcement\tO\n.\tO\n\nIn\tO\nGroup\tO\n1\tO\nthe\tO\nrats\tO\nwere\tO\ntrained\tO\nunder\tO\nthe\tO\ninfluence\tO\nof\tO\npentobarbital\tB-Chemical\nto\tO\nrun\tO\nto\tO\nthe\tO\nsame\tO\nshelf\tO\nas\tO\nin\tO\nthe\tO\nnormal\tO\nstate\tO\n.\tO\n\nIn\tO\nGroup\tO\n2\tO\nthe\tO\nrats\tO\nwere\tO\ntrained\tO\nto\tO\napproach\tO\ndifferent\tO\nshelves\tO\nin\tO\ndifferent\tO\ndrug\tO\nstates\tO\n.\tO\n\nIt\tO\nwas\tO\nshown\tO\nthat\tO\nmemory\tB-Disease\ndissociation\tI-Disease\noccurred\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nDifferences\tO\nin\tO\nthe\tO\nparameters\tO\nof\tO\ntraining\tO\nunder\tO\nthe\tO\ninfluence\tO\nof\tO\npentobarbital\tB-Chemical\nbetween\tO\nGroups\tO\n1\tO\nand\tO\n2\tO\nwere\tO\nrevealed\tO\n.\tO\n\nThese\tO\nfindings\tO\nshow\tO\nthat\tO\nthe\tO\nbrain\tO\n-\tO\ndissociated\tO\nstate\tO\ninduced\tO\nby\tO\npentobarbital\tB-Chemical\nis\tO\nformed\tO\nwith\tO\nthe\tO\nparticipation\tO\nof\tO\nthe\tO\nmechanisms\tO\nof\tO\ninformation\tO\nperception\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nshort\tO\n-\tO\nterm\tO\nraloxifene\tB-Chemical\ntherapy\tO\non\tO\nfibrinolysis\tO\nmarkers\tO\n:\tO\nTAFI\tO\n,\tO\ntPA\tO\n,\tO\nand\tO\nPAI\tO\n-\tO\n1\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nMarkers\tO\nof\tO\nfibrinolysis\tO\n,\tO\nthrombin\tO\n-\tO\nactivatable\tO\nfibrinolysis\tO\ninhibitor\tO\n(\tO\nTAFI\tO\n)\tO\n,\tO\ntissue\tO\n-\tO\ntype\tO\nplasminogen\tO\nactivator\tO\n(\tO\ntPA\tO\n)\tO\n,\tO\nand\tO\nplasminogen\tO\nactivator\tO\ninhibitor\tO\n-\tO\n1\tO\n(\tO\nPAI\tO\n-\tO\n1\tO\n)\tO\nlevels\tO\nwere\tO\nstudied\tO\nfor\tO\nthe\tO\nevaluation\tO\nof\tO\nshort\tO\n-\tO\nterm\tO\neffects\tO\nof\tO\nraloxifene\tB-Chemical\nadministration\tO\nin\tO\npostmenopausal\tO\nwomen\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThirty\tO\n-\tO\nnine\tO\npostmenopausal\tO\nwomen\tO\nwith\tO\nosteopenia\tB-Disease\nor\tO\nosteoporosis\tB-Disease\nwere\tO\nincluded\tO\nin\tO\nthis\tO\nprospective\tO\n,\tO\ncontrolled\tO\nclinical\tO\nstudy\tO\n.\tO\n\nTwenty\tO\n-\tO\nfive\tO\nwomen\tO\nwere\tO\ngiven\tO\nraloxifene\tB-Chemical\nhydrochloride\tI-Chemical\n(\tO\n60\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nplus\tO\ncalcium\tB-Chemical\n(\tO\n500\tO\nmg\tO\n/\tO\nday\tO\n)\tO\n.\tO\n\nAge\tO\n-\tO\nmatched\tO\ncontrols\tO\n(\tO\nn\tO\n=\tO\n14\tO\n)\tO\nwere\tO\ngiven\tO\nonly\tO\ncalcium\tB-Chemical\n.\tO\n\nPlasma\tO\nTAFI\tO\n,\tO\ntPA\tO\n,\tO\nand\tO\nPAI\tO\n-\tO\n1\tO\nantigen\tO\nlevels\tO\nwere\tO\nmeasured\tO\nat\tO\nbaseline\tO\nand\tO\nafter\tO\n3\tO\nmonths\tO\nof\tO\ntreatment\tO\nby\tO\ncommercially\tO\navailable\tO\nELISA\tO\nkits\tO\n.\tO\n\nVariations\tO\nof\tO\nindividuals\tO\nwere\tO\nassessed\tO\nby\tO\nWilcoxon\tO\n'\tO\ns\tO\ntest\tO\n.\tO\n\nRelationship\tO\nbetween\tO\nthose\tO\nmarkers\tO\nand\tO\ndemographic\tO\ncharacteristics\tO\nwere\tO\ninvestigated\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThree\tO\nmonths\tO\nof\tO\nraloxifene\tB-Chemical\ntreatment\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nthe\tO\nplasma\tO\nTAFI\tO\nantigen\tO\nconcentrations\tO\n(\tO\n16\tO\n%\tO\nchange\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nand\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\ntPA\tO\nantigen\tO\nconcentrations\tO\n(\tO\n25\tO\n%\tO\nchange\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nA\tO\nsignificant\tO\ncorrelation\tO\nwas\tO\nfound\tO\nbetween\tO\nbaseline\tO\nTAFI\tO\nantigen\tO\nconcentrations\tO\nand\tO\nthe\tO\nduration\tO\nof\tO\namenorrhea\tB-Disease\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n;\tO\nr\tO\n=\tO\n0\tO\n.\tO\n33\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nWe\tO\nsuggest\tO\nthat\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\ndue\tO\nto\tO\nraloxifene\tB-Chemical\ntreatment\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nincreased\tO\ntPA\tO\nlevels\tO\n,\tO\nbut\tO\nnot\tO\nTAFI\tO\nlevels\tO\n.\tO\n\nValproate\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\n.\tO\n\nValproate\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\nis\tO\na\tO\nrare\tO\nsyndrome\tO\nthat\tO\nmay\tO\nmanifest\tO\nin\tO\notherwise\tO\nnormal\tO\nepileptic\tB-Disease\nindividuals\tO\n.\tO\n\nIt\tO\nmay\tO\neven\tO\npresent\tO\nin\tO\npatients\tO\nwho\tO\nhave\tO\ntolerated\tO\nthis\tO\nmedicine\tO\nwell\tO\nin\tO\nthe\tO\npast\tO\n.\tO\n\nIt\tO\nis\tO\nusually\tO\nbut\tO\nnot\tO\nnecessarily\tO\nassociated\tO\nwith\tO\nhyperammonemia\tB-Disease\n.\tO\n\nThe\tO\nEEG\tO\nshows\tO\ncharacteristic\tO\ntriphasic\tO\nwaves\tO\nin\tO\nmost\tO\npatients\tO\nwith\tO\nthis\tO\ncomplication\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nvalproate\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\nis\tO\npresented\tO\n.\tO\n\nThe\tO\nproblems\tO\nin\tO\ndiagnosing\tO\nthis\tO\ncondition\tO\nare\tO\nsubsequently\tO\ndiscussed\tO\n.\tO\n\nRecurrent\tO\ndysphonia\tB-Disease\nand\tO\nacitretin\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\nwoman\tO\ncomplaining\tO\nof\tO\ndysphonia\tB-Disease\nwhile\tO\nshe\tO\nwas\tO\ntreated\tO\nby\tO\nacitretin\tB-Chemical\n.\tO\n\nHer\tO\nsymptoms\tO\ntotally\tO\nregressed\tO\nafter\tO\ndrug\tO\nwithdrawal\tO\nand\tO\nreappeared\tO\nwhen\tO\nacitretin\tB-Chemical\nwas\tO\nreintroduced\tO\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\ncase\tO\nof\tO\nacitretin\tB-Chemical\n-\tO\ninduced\tO\ndysphonia\tB-Disease\n.\tO\n\nThis\tO\neffect\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nthe\tO\npharmacological\tO\neffect\tO\nof\tO\nthis\tO\ndrug\tO\non\tO\nmucous\tO\nmembranes\tO\n.\tO\n\nNitro\tB-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nmethyl\tI-Chemical\nester\tI-Chemical\n:\tO\na\tO\npotential\tO\nprotector\tO\nagainst\tO\ngentamicin\tB-Chemical\nototoxicity\tB-Disease\n.\tO\n\nThe\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\ninhibitor\tO\nnitro\tB-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nmethyl\tI-Chemical\nester\tI-Chemical\n(\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n)\tO\nmay\tO\nact\tO\nas\tO\nan\tO\notoprotectant\tO\nagainst\tO\nhigh\tB-Disease\n-\tI-Disease\nfrequency\tI-Disease\nhearing\tI-Disease\nloss\tI-Disease\ncaused\tO\nby\tO\ngentamicin\tB-Chemical\n,\tO\nbut\tO\nfurther\tO\nstudies\tO\nare\tO\nneeded\tO\nto\tO\nconfirm\tO\nthis\tO\n.\tO\nAminoglycoside\tB-Chemical\nantibiotics\tO\nare\tO\nstill\tO\nwidely\tO\nused\tO\nby\tO\nvirtue\tO\nof\tO\ntheir\tO\nefficacy\tO\nand\tO\nlow\tO\ncost\tO\n.\tO\n\nTheir\tO\nototoxicity\tB-Disease\nis\tO\na\tO\nserious\tO\nhealth\tO\nproblem\tO\nand\tO\n,\tO\nas\tO\ntheir\tO\nototoxic\tB-Disease\nmechanism\tO\ninvolves\tO\nthe\tO\nproduction\tO\nof\tO\nNO\tB-Chemical\n,\tO\nwe\tO\nneed\tO\nto\tO\nassess\tO\nthe\tO\nuse\tO\nof\tO\nNO\tB-Chemical\ninhibitors\tO\nfor\tO\nthe\tO\nprevention\tO\nof\tO\naminoglycoside\tB-Chemical\n-\tO\ninduced\tO\nsensorineural\tB-Disease\nhearing\tI-Disease\nloss\tI-Disease\n.\tO\n\nIn\tO\nthis\tO\nexperimental\tO\nstudy\tO\nwe\tO\nused\tO\n30\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\n,\tO\n27\tO\nof\tO\nwhich\tO\nhad\tO\ngentamicin\tB-Chemical\ninstilled\tO\ninto\tO\nthe\tO\nmiddle\tO\near\tO\n.\tO\n\nThe\tO\notoprotectant\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\nwas\tO\nadministered\tO\ntopically\tO\nto\tO\n12\tO\n/\tO\n27\tO\nanimals\tO\n.\tO\n\nIts\tO\neffect\tO\nwas\tO\ndetermined\tO\nin\tO\nterms\tO\nof\tO\nattenuation\tO\nof\tO\nhearing\tB-Disease\nloss\tI-Disease\n,\tO\nmeasured\tO\nby\tO\nshifts\tO\nin\tO\nthe\tO\nauditory\tO\nbrainstem\tO\nresponse\tO\nthreshold\tO\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\nreduced\tO\ngentamicin\tB-Chemical\n-\tO\ninduced\tO\nhearing\tB-Disease\nloss\tI-Disease\nin\tO\nthe\tO\nhigh\tO\n-\tO\nfrequency\tO\nrange\tO\n,\tO\nbut\tO\ngave\tO\nno\tO\nprotection\tO\nin\tO\nthe\tO\nmiddle\tO\nor\tO\nlow\tO\nfrequencies\tO\n.\tO\n\nSafety\tO\nprofile\tO\nof\tO\na\tO\nnicotine\tB-Chemical\nlozenge\tO\ncompared\tO\nwith\tO\nthat\tO\nof\tO\nnicotine\tB-Chemical\ngum\tO\nin\tO\nadult\tO\nsmokers\tO\nwith\tO\nunderlying\tO\nmedical\tO\nconditions\tO\n:\tO\na\tO\n12\tO\n-\tO\nweek\tO\n,\tO\nrandomized\tO\n,\tO\nopen\tO\n-\tO\nlabel\tO\nstudy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nNicotine\tB-Chemical\npolacrilex\tO\nlozenges\tO\ndeliver\tO\n25\tO\n%\tO\nto\tO\n27\tO\n%\tO\nmore\tO\nnicotine\tB-Chemical\ncompared\tO\nwith\tO\nequivalent\tO\ndoses\tO\nof\tO\nnicotine\tB-Chemical\npolacrilex\tO\ngum\tO\n.\tO\n\nThe\tO\nincreased\tO\nnicotine\tB-Chemical\nexposure\tO\nfrom\tO\nthe\tO\nlozenge\tO\nhas\tO\nraised\tO\nquestions\tO\nabout\tO\nthe\tO\nrelative\tO\nsafety\tO\nof\tO\nthe\tO\nlozenge\tO\nand\tO\ngum\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ncompare\tO\nthe\tO\nsafety\tO\nprofiles\tO\nof\tO\nthe\tO\n4\tO\n-\tO\nmg\tO\nnicotine\tB-Chemical\nlozenge\tO\nand\tO\n4\tO\n-\tO\nmg\tO\nnicotine\tB-Chemical\ngum\tO\nin\tO\nsmokers\tO\nwith\tO\nselected\tO\nlabel\tO\n-\tO\nrestricted\tO\ndiseases\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nwas\tO\na\tO\nmulticenter\tO\n,\tO\nrandomized\tO\n,\tO\nopen\tO\n-\tO\nlabel\tO\nstudy\tO\nin\tO\nadult\tO\nsmokers\tO\nwith\tO\nheart\tB-Disease\ndisease\tI-Disease\n,\tO\nhypertension\tB-Disease\nnot\tO\ncontrolled\tO\nby\tO\nmedication\tO\n,\tO\nand\tO\n/\tO\nor\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\n.\tO\n\nPatients\tO\nwere\tO\nrandomized\tO\nin\tO\na\tO\n1\tO\n:\tO\n1\tO\nratio\tO\nto\tO\nreceive\tO\nthe\tO\n4\tO\n-\tO\nmg\tO\nnicotine\tB-Chemical\nlozenge\tO\nor\tO\n4\tO\n-\tO\nmg\tO\nnicotine\tB-Chemical\ngum\tO\n.\tO\n\nSafety\tO\nassessments\tO\nwere\tO\nmade\tO\nat\tO\nbaseline\tO\nand\tO\nat\tO\n2\tO\n,\tO\n4\tO\n,\tO\n6\tO\n,\tO\nand\tO\n12\tO\nweeks\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\nproduct\tO\nuse\tO\n.\tO\n\nRESULTS\tO\n:\tO\nNine\tO\nhundred\tO\none\tO\npatients\tO\nwere\tO\nrandomized\tO\nto\tO\ntreatment\tO\n,\tO\n447\tO\nwho\tO\nreceived\tO\nthe\tO\nlozenge\tO\nand\tO\n454\tO\nwho\tO\nreceived\tO\nthe\tO\ngum\tO\n(\tO\nsafety\tO\npopulation\tO\n)\tO\n.\tO\n\nThe\tO\nmajority\tO\nwere\tO\nwomen\tO\n(\tO\n52\tO\n.\tO\n7\tO\n%\tO\n)\tO\n.\tO\n\nPatients\tO\n'\tO\nmean\tO\nage\tO\nwas\tO\n53\tO\n.\tO\n9\tO\nyears\tO\n,\tO\ntheir\tO\nmean\tO\nweight\tO\nwas\tO\n193\tO\n.\tO\n9\tO\npounds\tO\n,\tO\nand\tO\nthey\tO\nsmoked\tO\na\tO\nmean\tO\nof\tO\n25\tO\n.\tO\n2\tO\ncigarettes\tO\nper\tO\nday\tO\nat\tO\nbaseline\tO\n.\tO\n\nFive\tO\nhundred\tO\nfifty\tO\n-\tO\nthree\tO\npatients\tO\n,\tO\n264\tO\ntaking\tO\nthe\tO\nlozenge\tO\nand\tO\n289\tO\ntaking\tO\nthe\tO\ngum\tO\n,\tO\nused\tO\nthe\tO\nstudy\tO\nproduct\tO\nfor\tO\n>\tO\nor\tO\n=\tO\n4\tO\ndays\tO\nper\tO\nweek\tO\nduring\tO\nthe\tO\nfirst\tO\n2\tO\nweeks\tO\n(\tO\nevaluable\tO\npopulation\tO\n)\tO\n.\tO\n\nThe\tO\nnicotine\tB-Chemical\nlozenge\tO\nand\tO\nnicotine\tB-Chemical\ngum\tO\nwere\tO\nequally\tO\nwell\tO\ntolerated\tO\n,\tO\ndespite\tO\nincreased\tO\nnicotine\tB-Chemical\nexposure\tO\nfrom\tO\nthe\tO\nlozenge\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nadverse\tO\nevents\tO\nin\tO\nthe\tO\n2\tO\ngroups\tO\nwas\tO\nsimilar\tO\nduring\tO\nthe\tO\nfirst\tO\n2\tO\nweeks\tO\nof\tO\nproduct\tO\nuse\tO\n(\tO\nevaluation\tO\npopulation\tO\n:\tO\n55\tO\n.\tO\n3\tO\n%\tO\nlozenge\tO\n,\tO\n54\tO\n.\tO\n7\tO\n%\tO\ngum\tO\n)\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nduring\tO\nthe\tO\nentire\tO\nstudy\tO\n(\tO\nsafety\tO\npopulation\tO\n:\tO\n63\tO\n.\tO\n8\tO\n%\tO\nand\tO\n58\tO\n.\tO\n6\tO\n%\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nStratification\tO\nof\tO\npatients\tO\nby\tO\nsex\tO\n,\tO\nage\tO\n,\tO\nextent\tO\nof\tO\nconcurrent\tO\nsmoking\tO\n,\tO\nextent\tO\nof\tO\nproduct\tO\nuse\tO\n,\tO\nand\tO\nseverity\tO\nof\tO\nadverse\tO\nevents\tO\nrevealed\tO\nno\tO\nclinically\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\nthe\tO\nlozenge\tO\nand\tO\ngum\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tO\nevents\tO\nwere\tO\nnausea\tB-Disease\n(\tO\n17\tO\n.\tO\n2\tO\n%\tO\nand\tO\n16\tO\n.\tO\n1\tO\n%\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n-\tO\n3\tO\n.\tO\n7\tO\nto\tO\n6\tO\n.\tO\n0\tO\n)\tO\n,\tO\nhiccups\tB-Disease\n(\tO\n10\tO\n.\tO\n7\tO\n%\tO\nand\tO\n6\tO\n.\tO\n6\tO\n%\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n0\tO\n.\tO\n5\tO\nto\tO\n7\tO\n.\tO\n8\tO\n)\tO\n,\tO\nand\tO\nheadache\tB-Disease\n(\tO\n8\tO\n.\tO\n7\tO\n%\tO\nand\tO\n9\tO\n.\tO\n9\tO\n%\tO\n;\tO\n95\tO\n%\tO\nCl\tO\n,\tO\n-\tO\n5\tO\n.\tO\n0\tO\nto\tO\n2\tO\n.\tO\n6\tO\n)\tO\n.\tO\n\nSerious\tO\nadverse\tO\nevents\tO\nwere\tO\nreported\tO\nin\tO\n11\tO\nand\tO\n13\tO\npatients\tO\nin\tO\nthe\tO\nrespective\tO\ngroups\tO\n.\tO\n\nFewer\tO\nthan\tO\n6\tO\n%\tO\nof\tO\npatients\tO\nin\tO\neither\tO\ngroup\tO\nwere\tO\nconsidered\tO\nby\tO\nthe\tO\ninvestigator\tO\nto\tO\nhave\tO\na\tO\nworsening\tO\nof\tO\ntheir\tO\noverall\tO\ndisease\tO\ncondition\tO\nduring\tO\nthe\tO\nstudy\tO\n.\tO\n\nThe\tO\nmajority\tO\nof\tO\npatients\tO\n(\tO\n>\tO\n60\tO\n%\tO\n)\tO\nexperienced\tO\nno\tO\nchange\tO\nin\tO\ntheir\tO\ndisease\tO\nstatus\tO\nfrom\tO\nbaseline\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\n4\tO\n-\tO\nmg\tO\nnicotine\tB-Chemical\nlozenge\tO\nand\tO\n4\tO\n-\tO\nmg\tO\nnicotine\tB-Chemical\ngum\tO\nhad\tO\ncomparable\tO\nsafety\tO\nprofiles\tO\nin\tO\nthese\tO\npatients\tO\nwith\tO\nlabel\tO\n-\tO\nrestricted\tO\nmedical\tO\nconditions\tO\n.\tO\n\nPharmacological\tO\nmodulation\tO\nof\tO\npain\tB-Disease\n-\tO\nrelated\tO\nbrain\tO\nactivity\tO\nduring\tO\nnormal\tO\nand\tO\ncentral\tO\nsensitization\tO\nstates\tO\nin\tO\nhumans\tO\n.\tO\n\nAbnormal\tO\nprocessing\tO\nof\tO\nsomatosensory\tO\ninputs\tO\nin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n(\tO\ncentral\tO\nsensitization\tO\n)\tO\nis\tO\nthe\tO\nmechanism\tO\naccounting\tO\nfor\tO\nthe\tO\nenhanced\tO\npain\tB-Disease\nsensitivity\tO\nin\tO\nthe\tO\nskin\tO\nsurrounding\tO\ntissue\tB-Disease\ninjury\tI-Disease\n(\tO\nsecondary\tB-Disease\nhyperalgesia\tI-Disease\n)\tO\n.\tO\n\nSecondary\tB-Disease\nhyperalgesia\tI-Disease\nshares\tO\nclinical\tO\ncharacteristics\tO\nwith\tO\nneurogenic\tB-Disease\nhyperalgesia\tI-Disease\nin\tO\npatients\tO\nwith\tO\nneuropathic\tB-Disease\npain\tI-Disease\n.\tO\n\nAbnormal\tO\nbrain\tO\nresponses\tO\nto\tO\nsomatosensory\tO\nstimuli\tO\nhave\tO\nbeen\tO\nfound\tO\nin\tO\npatients\tO\nwith\tO\nhyperalgesia\tB-Disease\nas\tO\nwell\tO\nas\tO\nin\tO\nnormal\tO\nsubjects\tO\nduring\tO\nexperimental\tO\ncentral\tO\nsensitization\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nassess\tO\nthe\tO\neffects\tO\nof\tO\ngabapentin\tB-Chemical\n,\tO\na\tO\ndrug\tO\neffective\tO\nin\tO\nneuropathic\tB-Disease\npain\tI-Disease\npatients\tO\n,\tO\non\tO\nbrain\tO\nprocessing\tO\nof\tO\nnociceptive\tO\ninformation\tO\nin\tO\nnormal\tO\nand\tO\ncentral\tO\nsensitization\tO\nstates\tO\n.\tO\n\nUsing\tO\nfunctional\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n(\tO\nfMRI\tO\n)\tO\nin\tO\nnormal\tO\nvolunteers\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\ngabapentin\tB-Chemical\n-\tO\ninduced\tO\nmodulation\tO\nof\tO\nbrain\tO\nactivity\tO\nin\tO\nresponse\tO\nto\tO\nnociceptive\tO\nmechanical\tO\nstimulation\tO\nof\tO\nnormal\tO\nskin\tO\nand\tO\ncapsaicin\tB-Chemical\n-\tO\ninduced\tO\nsecondary\tB-Disease\nhyperalgesia\tI-Disease\n.\tO\n\nThe\tO\ndose\tO\nof\tO\ngabapentin\tB-Chemical\nwas\tO\n1\tO\n,\tO\n800\tO\nmg\tO\nper\tO\nos\tO\n,\tO\nin\tO\na\tO\nsingle\tO\nadministration\tO\n.\tO\n\nWe\tO\nfound\tO\nthat\tO\n(\tO\ni\tO\n)\tO\ngabapentin\tB-Chemical\nreduced\tO\nthe\tO\nactivations\tO\nin\tO\nthe\tO\nbilateral\tO\noperculoinsular\tO\ncortex\tO\n,\tO\nindependently\tO\nof\tO\nthe\tO\npresence\tO\nof\tO\ncentral\tO\nsensitization\tO\n;\tO\n(\tO\nii\tO\n)\tO\ngabapentin\tB-Chemical\nreduced\tO\nthe\tO\nactivation\tO\nin\tO\nthe\tO\nbrainstem\tO\n,\tO\nonly\tO\nduring\tO\ncentral\tO\nsensitization\tO\n;\tO\n(\tO\niii\tO\n)\tO\ngabapentin\tB-Chemical\nsuppressed\tO\nstimulus\tO\n-\tO\ninduced\tO\ndeactivations\tO\n,\tO\nonly\tO\nduring\tO\ncentral\tO\nsensitization\tO\n;\tO\nthis\tO\neffect\tO\nwas\tO\nmore\tO\nrobust\tO\nthan\tO\nthe\tO\neffect\tO\non\tO\nbrain\tO\nactivation\tO\n.\tO\n\nThe\tO\nobserved\tO\ndrug\tO\n-\tO\ninduced\tO\neffects\tO\nwere\tO\nnot\tO\ndue\tO\nto\tO\nchanges\tO\nin\tO\nthe\tO\nbaseline\tO\nfMRI\tO\nsignal\tO\n.\tO\n\nThese\tO\nfindings\tO\nindicate\tO\nthat\tO\ngabapentin\tB-Chemical\nhas\tO\na\tO\nmeasurable\tO\nantinociceptive\tO\neffect\tO\nand\tO\na\tO\nstronger\tO\nantihyperalgesic\tO\neffect\tO\nmost\tO\nevident\tO\nin\tO\nthe\tO\nbrain\tO\nareas\tO\nundergoing\tO\ndeactivation\tO\n,\tO\nthus\tO\nsupporting\tO\nthe\tO\nconcept\tO\nthat\tO\ngabapentin\tB-Chemical\nis\tO\nmore\tO\neffective\tO\nin\tO\nmodulating\tO\nnociceptive\tO\ntransmission\tO\nwhen\tO\ncentral\tO\nsensitization\tO\nis\tO\npresent\tO\n.\tO\n\nInvestigation\tO\nof\tO\nmitochondrial\tO\ninvolvement\tO\nin\tO\nthe\tO\nexperimental\tO\nmodel\tO\nof\tO\nepilepsy\tB-Disease\ninduced\tO\nby\tO\npilocarpine\tB-Chemical\n.\tO\n\nMitochondrial\tB-Disease\nabnormalities\tI-Disease\nhave\tO\nbeen\tO\nassociated\tO\nwith\tO\nseveral\tO\naspects\tO\nof\tO\nepileptogenesis\tO\n,\tO\nsuch\tO\nas\tO\nenergy\tO\ngeneration\tO\n,\tO\ncontrol\tO\nof\tO\ncell\tO\ndeath\tB-Disease\n,\tO\nneurotransmitter\tO\nsynthesis\tO\n,\tO\nand\tO\nfree\tO\nradical\tO\n(\tO\nFR\tO\n)\tO\nproduction\tO\n.\tO\n\nIncreased\tO\nproduction\tO\nof\tO\nFRs\tO\nmay\tO\ncause\tO\nmtDNA\tO\ndamage\tO\nleading\tO\nto\tO\ndecreased\tO\nactivities\tO\nof\tO\noxidative\tO\nphosphorylation\tO\ncomplexes\tO\ncontaining\tO\nmtDNA\tO\n-\tO\nencoded\tO\nsubunits\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nwhether\tO\nincreased\tO\ngeneration\tO\nof\tO\nFR\tO\nduring\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nwould\tO\nbe\tO\nsufficient\tO\nto\tO\nprovoke\tO\nabnormalities\tO\nin\tO\nmtDNA\tO\nand\tO\nin\tO\nthe\tO\nexpression\tO\nand\tO\nactivity\tO\nof\tO\ncytochrome\tO\nc\tO\noxidase\tO\n(\tO\nCCO\tO\n)\tO\n,\tO\ncomplex\tO\nIV\tO\nof\tO\nthe\tO\nrespiratory\tO\nchain\tO\n,\tO\nin\tO\nthe\tO\nchronic\tO\nphase\tO\nof\tO\nthe\tO\npilocarpine\tB-Chemical\nmodel\tO\nof\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\n.\tO\n\nDNA\tO\nanalysis\tO\nrevealed\tO\nlow\tO\namounts\tO\nof\tO\na\tO\n4\tO\n.\tO\n8\tO\nkb\tO\nmtDNA\tO\ndeletion\tO\nbut\tO\nwith\tO\nno\tO\ndifferences\tO\nin\tO\nfrequency\tO\nor\tO\nquantity\tO\nin\tO\nthe\tO\ncontrol\tO\nand\tO\nexperimental\tO\ngroups\tO\n.\tO\n\nWe\tO\ndid\tO\nnot\tO\nfind\tO\nabnormalities\tO\nin\tO\nthe\tO\nexpression\tO\nand\tO\ndistribution\tO\nof\tO\nan\tO\nmtDNA\tO\n-\tO\nencoded\tO\nsubunit\tO\nof\tO\nCCO\tO\n(\tO\nCCO\tO\n-\tO\nI\tO\n)\tO\nor\tO\na\tO\nrelative\tO\ndecrease\tO\nin\tO\nCCO\tO\n-\tO\nI\tO\nwhen\tO\ncompared\tO\nwith\tO\nnuclear\tO\n-\tO\nencoded\tO\nsubunits\tO\n(\tO\nCCO\tO\n-\tO\nIV\tO\nand\tO\nSDH\tO\n-\tO\nfp\tO\n)\tO\n.\tO\n\nNo\tO\nabnormality\tO\nin\tO\nCCO\tO\nactivity\tO\nwas\tO\nobserved\tO\nthrough\tO\nhistochemistry\tO\n.\tO\n\nAlthough\tO\nevidences\tO\nof\tO\nmitochondrial\tB-Disease\nabnormalities\tI-Disease\nwere\tO\nfound\tO\nin\tO\npreviously\tO\npublished\tO\nstudies\tO\n,\tO\nour\tO\nresults\tO\ndo\tO\nnot\tO\nsuggest\tO\nthat\tO\nthe\tO\nFRs\tO\n,\tO\ngenerated\tO\nduring\tO\nthe\tO\nacute\tO\nphase\tO\n,\tO\ndetermined\tO\nimportant\tO\nabnormalities\tO\nin\tO\nmtDNA\tO\n,\tO\nin\tO\nexpression\tO\nof\tO\nCCO\tO\n-\tO\nI\tO\n,\tO\nand\tO\nin\tO\nCCO\tO\nactivity\tO\n.\tO\n\nAdverse\tO\neffect\tO\nof\tO\nthe\tO\ncalcium\tB-Chemical\nchannel\tO\nblocker\tO\nnitrendipine\tB-Chemical\non\tO\nnephrosclerosis\tB-Disease\nin\tO\nrats\tO\nwith\tO\nrenovascular\tB-Disease\nhypertension\tI-Disease\n.\tO\n\nThe\tO\neffect\tO\nof\tO\na\tO\n6\tO\n-\tO\nweek\tO\ntreatment\tO\nwith\tO\nthe\tO\ncalcium\tB-Chemical\nchannel\tO\nblocker\tO\nnitrendipine\tB-Chemical\nor\tO\nthe\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitor\tO\nenalapril\tB-Chemical\non\tO\nblood\tO\npressure\tO\n,\tO\nalbuminuria\tB-Disease\n,\tO\nrenal\tO\nhemodynamics\tO\n,\tO\nand\tO\nmorphology\tO\nof\tO\nthe\tO\nnonclipped\tO\nkidney\tO\nwas\tO\nstudied\tO\nin\tO\nrats\tO\nwith\tO\ntwo\tO\n-\tO\nkidney\tO\n,\tO\none\tO\nclip\tO\nrenovascular\tB-Disease\nhypertension\tI-Disease\n.\tO\n\nSix\tO\nweeks\tO\nafter\tO\nclipping\tO\nof\tO\none\tO\nrenal\tO\nartery\tO\n,\tO\nhypertensive\tB-Disease\nrats\tO\n(\tO\n178\tO\n+\tO\n/\tO\n-\tO\n4\tO\nmm\tO\nHg\tO\n)\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nthree\tO\ngroups\tO\n:\tO\nuntreated\tO\nhypertensive\tB-Disease\ncontrols\tO\n(\tO\nn\tO\n=\tO\n8\tO\n)\tO\n,\tO\nenalapril\tB-Chemical\n-\tO\ntreated\tO\n(\tO\nn\tO\n=\tO\n8\tO\n)\tO\n,\tO\nor\tO\nnitrendipine\tB-Chemical\n-\tO\ntreated\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\n.\tO\n\nSham\tO\n-\tO\noperated\tO\nrats\tO\nserved\tO\nas\tO\nnormotensive\tO\ncontrols\tO\n(\tO\n128\tO\n+\tO\n/\tO\n-\tO\n3\tO\nmm\tO\nHg\tO\n,\tO\nn\tO\n=\tO\n8\tO\n)\tO\n.\tO\n\nAfter\tO\n6\tO\nweeks\tO\nof\tO\ntreatment\tO\n,\tO\nrenal\tO\nhemodynamics\tO\n(\tO\nglomerular\tO\nfiltration\tO\nrate\tO\nand\tO\nrenal\tO\nplasma\tO\nflow\tO\n)\tO\nwere\tO\nmeasured\tO\nin\tO\nthe\tO\nanesthetized\tO\nrats\tO\n.\tO\n\nRenal\tO\ntissue\tO\nwas\tO\nobtained\tO\nfor\tO\ndetermination\tO\nof\tO\nglomerular\tO\nsize\tO\nand\tO\nsclerosis\tO\n.\tO\n\nEnalapril\tB-Chemical\nbut\tO\nnot\tO\nnitrendipine\tB-Chemical\nreduced\tO\nblood\tO\npressure\tO\nsignificantly\tO\n.\tO\n\nAfter\tO\n6\tO\nweeks\tO\nof\tO\ntherapy\tO\n,\tO\nglomerular\tO\nfiltration\tO\nrate\tO\nwas\tO\nnot\tO\ndifferent\tO\namong\tO\nthe\tO\nstudied\tO\ngroups\tO\n.\tO\n\nRenal\tO\nplasma\tO\nflow\tO\nincreased\tO\n,\tO\nbut\tO\nalbumin\tO\nexcretion\tO\nand\tO\nglomerulosclerosis\tB-Disease\ndid\tO\nnot\tO\nchange\tO\nafter\tO\nenalapril\tB-Chemical\ntreatment\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nin\tO\nthe\tO\nnitrendipine\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\nalbuminuria\tB-Disease\nincreased\tO\nfrom\tO\n12\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n2\tO\nprogressively\tO\nto\tO\n163\tO\n+\tO\n/\tO\n-\tO\n55\tO\ncompared\tO\nwith\tO\n19\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n9\tO\nmg\tO\n/\tO\n24\tO\nhr\tO\nin\tO\nthe\tO\nhypertensive\tB-Disease\ncontrols\tO\n.\tO\n\nFurthermore\tO\n,\tO\nglomerulosclerosis\tB-Disease\nindex\tO\nwas\tO\nsignificantly\tO\nincreased\tO\nin\tO\nthe\tO\nnitrendipine\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\ncompared\tO\nwith\tO\nthe\tO\nhypertensive\tB-Disease\ncontrols\tO\n(\tO\n0\tO\n.\tO\n38\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nversus\tO\n0\tO\n.\tO\n13\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n04\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nglomerular\tO\nsize\tO\nwas\tO\nhigher\tO\nin\tO\nthe\tO\nnitrendipine\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\n(\tO\n14\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n17\tO\n10\tO\n(\tO\n-\tO\n3\tO\n)\tO\nmm2\tO\n)\tO\nbut\tO\nlower\tO\nin\tO\nthe\tO\nenalapril\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\n(\tO\n11\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n15\tO\n10\tO\n(\tO\n-\tO\n3\tO\n)\tO\nmm2\tO\n)\tO\ncompared\tO\nwith\tO\nthe\tO\nhypertensive\tB-Disease\ncontrols\tO\n(\tO\n12\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n17\tO\n10\tO\n(\tO\n-\tO\n3\tO\n)\tO\nmm2\tO\n)\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nKetoconazole\tB-Chemical\ninduced\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\nwithout\tO\nconcomitant\tO\nuse\tO\nof\tO\nQT\tO\ninterval\tO\n-\tO\nprolonging\tO\ndrug\tO\n.\tO\n\nKetoconazole\tB-Chemical\nis\tO\nnot\tO\nknown\tO\nto\tO\nbe\tO\nproarrhythmic\tO\nwithout\tO\nconcomitant\tO\nuse\tO\nof\tO\nQT\tO\ninterval\tO\n-\tO\nprolonging\tO\ndrugs\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\nwoman\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nwho\tO\ndeveloped\tO\na\tO\nmarkedly\tO\nprolonged\tB-Disease\nQT\tI-Disease\ninterval\tI-Disease\nand\tO\ntorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\nTdP\tB-Disease\n)\tO\nafter\tO\ntaking\tO\nketoconazole\tB-Chemical\nfor\tO\ntreatment\tO\nof\tO\nfungal\tB-Disease\ninfection\tI-Disease\n.\tO\n\nHer\tO\nQT\tO\ninterval\tO\nreturned\tO\nto\tO\nnormal\tO\nupon\tO\nwithdrawal\tO\nof\tO\nketoconazole\tB-Chemical\n.\tO\n\nGenetic\tO\nstudy\tO\ndid\tO\nnot\tO\nfind\tO\nany\tO\nmutation\tO\nin\tO\nher\tO\ngenes\tO\nthat\tO\nencode\tO\ncardiac\tO\nIKr\tO\nchannel\tO\nproteins\tO\n.\tO\n\nWe\tO\npostulate\tO\nthat\tO\nby\tO\nvirtue\tO\nof\tO\nits\tO\ndirect\tO\nblocking\tO\naction\tO\non\tO\nIKr\tO\n,\tO\nketoconazole\tB-Chemical\nalone\tO\nmay\tO\nprolong\tO\nQT\tO\ninterval\tO\nand\tO\ninduce\tO\nTdP\tB-Disease\n.\tO\n\nThis\tO\ncalls\tO\nfor\tO\nattention\tO\nwhen\tO\nketoconazole\tB-Chemical\nis\tO\nadministered\tO\nto\tO\npatients\tO\nwith\tO\nrisk\tO\nfactors\tO\nfor\tO\nacquired\tO\nlong\tB-Disease\nQT\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nCerebral\tB-Disease\nvasculitis\tI-Disease\nfollowing\tO\noral\tO\nmethylphenidate\tB-Chemical\nintake\tO\nin\tO\nan\tO\nadult\tO\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nMethylphenidate\tB-Chemical\nis\tO\nstructurally\tO\nand\tO\nfunctionally\tO\nsimilar\tO\nto\tO\namphetamine\tB-Chemical\n.\tO\n\nCerebral\tB-Disease\nvasculitis\tI-Disease\nassociated\tO\nwith\tO\namphetamine\tB-Disease\nabuse\tI-Disease\nis\tO\nwell\tO\ndocumented\tO\n,\tO\nand\tO\nin\tO\nrare\tO\ncases\tO\nischaemic\tB-Disease\nstroke\tI-Disease\nhas\tO\nbeen\tO\nreported\tO\nafter\tO\nmethylphenidate\tB-Chemical\nintake\tO\nin\tO\nchildren\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n63\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfemale\tO\nwho\tO\nwas\tO\ntreated\tO\nwith\tO\nmethylphenidate\tB-Chemical\ndue\tO\nto\tO\nhyperactivity\tB-Disease\nand\tO\nsuffered\tO\nfrom\tO\nmultiple\tO\nischaemic\tB-Disease\nstrokes\tI-Disease\n.\tO\n\nWe\tO\nconsider\tO\ndrug\tO\n-\tO\ninduced\tO\ncerebral\tB-Disease\nvasculitis\tI-Disease\nas\tO\nthe\tO\nmost\tO\nlikely\tO\ncause\tO\nof\tO\nrecurrent\tO\nischaemic\tB-Disease\nstrokes\tI-Disease\nin\tO\nthe\tO\nabsence\tO\nof\tO\nany\tO\npathological\tO\nfindings\tO\nduring\tO\nthe\tO\ndiagnostic\tO\nwork\tO\n-\tO\nup\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nmethylphenidate\tB-Chemical\nmediated\tO\nvasculitis\tB-Disease\nshould\tO\nbe\tO\nconsidered\tO\nin\tO\npatients\tO\nwith\tO\nneurological\tO\nsymptoms\tO\nand\tO\na\tO\nhistory\tO\nof\tO\nmethylphenidate\tB-Chemical\ntherapy\tO\n.\tO\n\nThis\tO\npotential\tO\nside\tO\n-\tO\neffect\tO\n,\tO\nthough\tO\nvery\tO\nrare\tO\n,\tO\nrepresents\tO\none\tO\nmore\tO\nreason\tO\nto\tO\nbe\tO\nvery\tO\nrestrictive\tO\nin\tO\nthe\tO\nuse\tO\nof\tO\nmethylphenidate\tB-Chemical\n.\tO\n\nMDMA\tB-Chemical\npolydrug\tO\nusers\tO\nshow\tO\nprocess\tO\n-\tO\nspecific\tO\ncentral\tO\nexecutive\tO\nimpairments\tO\ncoupled\tO\nwith\tO\nimpaired\tB-Disease\nsocial\tI-Disease\nand\tI-Disease\nemotional\tI-Disease\njudgement\tI-Disease\nprocesses\tI-Disease\n.\tO\n\nIn\tO\nrecent\tO\nyears\tO\nworking\tO\nmemory\tB-Disease\ndeficits\tI-Disease\nhave\tO\nbeen\tO\nreported\tO\nin\tO\nusers\tO\nof\tO\nMDMA\tB-Chemical\n(\tO\n3\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethylenedioxymethamphetamine\tI-Chemical\n,\tO\necstasy\tB-Chemical\n)\tO\n.\tO\n\nThe\tO\ncurrent\tO\nstudy\tO\naimed\tO\nto\tO\nassess\tO\nthe\tO\nimpact\tO\nof\tO\nMDMA\tB-Chemical\nuse\tO\non\tO\nthree\tO\nseparate\tO\ncentral\tO\nexecutive\tO\nprocesses\tO\n(\tO\nset\tO\nshifting\tO\n,\tO\ninhibition\tO\nand\tO\nmemory\tO\nupdating\tO\n)\tO\nand\tO\nalso\tO\non\tO\n\"\tO\nprefrontal\tO\n\"\tO\nmediated\tO\nsocial\tO\nand\tO\nemotional\tO\njudgement\tO\nprocesses\tO\n.\tO\n\nFifteen\tO\npolydrug\tO\necstasy\tB-Chemical\nusers\tO\nand\tO\n15\tO\npolydrug\tO\nnon\tO\n-\tO\necstasy\tB-Chemical\nuser\tO\ncontrols\tO\ncompleted\tO\na\tO\ngeneral\tO\ndrug\tO\nuse\tO\nquestionnaire\tO\n,\tO\nthe\tO\nBrixton\tO\nSpatial\tO\nAnticipation\tO\ntask\tO\n(\tO\nset\tO\nshifting\tO\n)\tO\n,\tO\nBackward\tO\nDigit\tO\nSpan\tO\nprocedure\tO\n(\tO\nmemory\tO\nupdating\tO\n)\tO\n,\tO\nInhibition\tO\nof\tO\nReturn\tO\n(\tO\ninhibition\tO\n)\tO\n,\tO\nan\tO\nemotional\tO\nintelligence\tO\nscale\tO\n,\tO\nthe\tO\nTromso\tO\nSocial\tO\nIntelligence\tO\nScale\tO\nand\tO\nthe\tO\nDysexecutive\tO\nQuestionnaire\tO\n(\tO\nDEX\tO\n)\tO\n.\tO\n\nCompared\tO\nwith\tO\nMDMA\tB-Chemical\n-\tO\nfree\tO\npolydrug\tO\ncontrols\tO\n,\tO\nMDMA\tB-Chemical\npolydrug\tO\nusers\tO\nshowed\tO\nimpairments\tO\nin\tO\nset\tO\nshifting\tO\nand\tO\nmemory\tO\nupdating\tO\n,\tO\nand\tO\nalso\tO\nin\tO\nsocial\tO\nand\tO\nemotional\tO\njudgement\tO\nprocesses\tO\n.\tO\n\nThe\tO\nlatter\tO\ntwo\tO\ndeficits\tO\nremained\tO\nsignificant\tO\nafter\tO\ncontrolling\tO\nfor\tO\nother\tO\ndrug\tO\nuse\tO\n.\tO\n\nThese\tO\ndata\tO\nlend\tO\nfurther\tO\nsupport\tO\nto\tO\nthe\tO\nproposal\tO\nthat\tO\ncognitive\tO\nprocesses\tO\nmediated\tO\nby\tO\nthe\tO\nprefrontal\tO\ncortex\tO\nmay\tO\nbe\tO\nimpaired\tO\nby\tO\nrecreational\tO\necstasy\tB-Chemical\nuse\tO\n.\tO\n\nPhase\tO\nII\tO\nstudy\tO\nof\tO\nthe\tO\namsacrine\tB-Chemical\nanalogue\tO\nCI\tB-Chemical\n-\tI-Chemical\n921\tI-Chemical\n(\tO\nNSC\tB-Chemical\n343499\tI-Chemical\n)\tO\nin\tO\nnon\tB-Disease\n-\tI-Disease\nsmall\tI-Disease\ncell\tI-Disease\nlung\tI-Disease\ncancer\tI-Disease\n.\tO\n\nCI\tB-Chemical\n-\tI-Chemical\n921\tI-Chemical\n(\tO\nNSC\tB-Chemical\n343499\tI-Chemical\n;\tO\n9\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nmethoxy\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n(\tI-Chemical\nmethylsulphonyl\tI-Chemical\n)\tI-Chemical\namino\tI-Chemical\n]\tI-Chemical\nphenyl\tI-Chemical\n]\tI-Chemical\namino\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n,\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\ndimethyl\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nacridinecarboxamide\tI-Chemical\n)\tO\nis\tO\na\tO\ntopoisomerase\tO\nII\tO\npoison\tO\nwith\tO\nhigh\tO\nexperimental\tO\nantitumour\tO\nactivity\tO\n.\tO\n\nIt\tO\nwas\tO\nadministered\tO\nby\tO\n15\tO\nmin\tO\ninfusion\tO\nto\tO\n16\tO\nevaluable\tO\npatients\tO\nwith\tO\nnon\tB-Disease\n-\tI-Disease\nsmall\tI-Disease\ncell\tI-Disease\nlung\tI-Disease\ncancer\tI-Disease\n(\tO\nNSCLC\tB-Disease\n)\tO\n(\tO\n7\tO\nwith\tO\nno\tO\nprior\tO\ntreatment\tO\n,\tO\n9\tO\npatients\tO\nin\tO\nrelapse\tO\nfollowing\tO\nsurgery\tO\n/\tO\nradiotherapy\tO\n)\tO\nat\tO\na\tO\ndose\tO\n(\tO\n648\tO\nmg\tO\n/\tO\nm2\tO\ndivided\tO\nover\tO\n3\tO\ndays\tO\n,\tO\nrepeated\tO\nevery\tO\n3\tO\nweeks\tO\n)\tO\ndetermined\tO\nby\tO\nphase\tO\nI\tO\ntrial\tO\n.\tO\n\nPatients\tO\nhad\tO\na\tO\nmedian\tO\nperformance\tO\nstatus\tO\nof\tO\n1\tO\n(\tO\nWHO\tO\n)\tO\n,\tO\nand\tO\nmedian\tO\nage\tO\nof\tO\n61\tO\nyears\tO\n.\tO\n\nThe\tO\nhistology\tO\ncomprised\tO\nsquamous\tB-Disease\ncarcinoma\tI-Disease\n(\tO\n11\tO\n)\tO\n,\tO\nadenocarcinoma\tB-Disease\n(\tO\n1\tO\n)\tO\n,\tO\nmixed\tO\nhistology\tO\n(\tO\n2\tO\n)\tO\n,\tO\nbronchio\tB-Disease\n-\tI-Disease\nalveolar\tI-Disease\ncarcinoma\tI-Disease\n(\tO\n1\tO\n)\tO\nand\tO\nlarge\tO\ncell\tO\nundifferentiated\tB-Disease\ncarcinoma\tI-Disease\n(\tO\n1\tO\n)\tO\n.\tO\n\nNeutropenia\tB-Disease\ngrade\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n3\tO\nwas\tO\nseen\tO\nin\tO\n15\tO\npatients\tO\n,\tO\ninfections\tB-Disease\nwith\tO\nrecovery\tO\nin\tO\n3\tO\n,\tO\nand\tO\ngrand\tO\nmal\tO\nseizures\tB-Disease\nin\tO\n1\tO\npatient\tO\n.\tO\n\nGrade\tO\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n2\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\noccurred\tO\nin\tO\n66\tO\n%\tO\ncourses\tO\nand\tO\nphlebitis\tB-Disease\nin\tO\nthe\tO\ninfusion\tO\narm\tO\nin\tO\n37\tO\n%\tO\n.\tO\n\n1\tO\npatient\tO\nwith\tO\nsquamous\tB-Disease\ncell\tI-Disease\ncarcinoma\tI-Disease\nachieved\tO\na\tO\npartial\tO\nresponse\tO\nlasting\tO\n5\tO\nmonths\tO\n.\tO\n\nFurther\tO\ntesting\tO\nin\tO\nthis\tO\nand\tO\nother\tO\ntumour\tB-Disease\ntypes\tO\nusing\tO\nmultiple\tO\ndaily\tO\nschedules\tO\nis\tO\nwarranted\tO\n.\tO\n\nPharmacokinetics\tO\nof\tO\ndesipramine\tB-Chemical\nHCl\tI-Chemical\nwhen\tO\nadministered\tO\nwith\tO\ncinacalcet\tB-Chemical\nHCl\tI-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nIn\tO\nvitro\tO\nwork\tO\nhas\tO\ndemonstrated\tO\nthat\tO\ncinacalcet\tB-Chemical\nis\tO\na\tO\nstrong\tO\ninhibitor\tO\nof\tO\ncytochrome\tO\nP450\tO\nisoenzyme\tO\n(\tO\nCYP\tO\n)\tO\n2D6\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nevaluate\tO\nthe\tO\neffect\tO\nof\tO\ncinacalcet\tB-Chemical\non\tO\nCYP2D6\tO\nactivity\tO\n,\tO\nusing\tO\ndesipramine\tB-Chemical\nas\tO\na\tO\nprobe\tO\nsubstrate\tO\n,\tO\nin\tO\nhealthy\tO\nsubjects\tO\n.\tO\n\nMETHODS\tO\n:\tO\nSeventeen\tO\nsubjects\tO\nwho\tO\nwere\tO\ngenotyped\tO\nas\tO\nCYP2D6\tO\nextensive\tO\nmetabolizers\tO\nwere\tO\nenrolled\tO\nin\tO\nthis\tO\nrandomized\tO\n,\tO\nopen\tO\n-\tO\nlabel\tO\n,\tO\ncrossover\tO\nstudy\tO\nto\tO\nreceive\tO\na\tO\nsingle\tO\noral\tO\ndose\tO\nof\tO\ndesipramine\tB-Chemical\n(\tO\n50\tO\nmg\tO\n)\tO\non\tO\ntwo\tO\nseparate\tO\noccasions\tO\n,\tO\nonce\tO\nalone\tO\nand\tO\nonce\tO\nafter\tO\nmultiple\tO\ndoses\tO\nof\tO\ncinacalcet\tB-Chemical\n(\tO\n90\tO\nmg\tO\nfor\tO\n7\tO\ndays\tO\n)\tO\n.\tO\n\nBlood\tO\nsamples\tO\nwere\tO\nobtained\tO\npredose\tO\nand\tO\nup\tO\nto\tO\n72\tO\nh\tO\npostdose\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFourteen\tO\nsubjects\tO\ncompleted\tO\nboth\tO\ntreatment\tO\narms\tO\n.\tO\n\nRelative\tO\nto\tO\ndesipramine\tB-Chemical\nalone\tO\n,\tO\nmean\tO\nAUC\tO\nand\tO\nC\tO\n(\tO\nmax\tO\n)\tO\nof\tO\ndesipramine\tB-Chemical\nincreased\tO\n3\tO\n.\tO\n6\tO\n-\tO\nand\tO\n1\tO\n.\tO\n8\tO\n-\tO\nfold\tO\nwhen\tO\ncoadministered\tO\nwith\tO\ncinacalcet\tB-Chemical\n.\tO\n\nThe\tO\nt\tO\n(\tO\n1\tO\n/\tO\n2\tO\n,\tO\nz\tO\n)\tO\nof\tO\ndesipramine\tB-Chemical\nwas\tO\nlonger\tO\nwhen\tO\ndesipramine\tB-Chemical\nwas\tO\ncoadministered\tO\nwith\tO\ncinacalcet\tB-Chemical\n(\tO\n21\tO\n.\tO\n0\tO\nversus\tO\n43\tO\n.\tO\n3\tO\nhs\tO\n)\tO\n.\tO\n\nThe\tO\nt\tO\n(\tO\nmax\tO\n)\tO\nwas\tO\nsimilar\tO\nbetween\tO\nthe\tO\nregimens\tO\n.\tO\n\nFewer\tO\nsubjects\tO\nreported\tO\nadverse\tO\nevents\tO\nfollowing\tO\ntreatment\tO\nwith\tO\ndesipramine\tB-Chemical\nalone\tO\nthan\tO\nwhen\tO\nreceiving\tO\ndesipramine\tB-Chemical\nwith\tO\ncinacalcet\tB-Chemical\n(\tO\n33\tO\nversus\tO\n86\tO\n%\tO\n)\tO\n,\tO\nthe\tO\nmost\tO\nfrequent\tO\nof\tO\nwhich\tO\n(\tO\nnausea\tB-Disease\nand\tO\nheadache\tB-Disease\n)\tO\nhave\tO\nbeen\tO\nreported\tO\nfor\tO\npatients\tO\ntreated\tO\nwith\tO\neither\tO\ndesipramine\tB-Chemical\nor\tO\ncinacalcet\tB-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nstudy\tO\ndemonstrates\tO\nthat\tO\ncinacalcet\tB-Chemical\nis\tO\na\tO\nstrong\tO\ninhibitor\tO\nof\tO\nCYP2D6\tO\n.\tO\n\nThese\tO\ndata\tO\nsuggest\tO\nthat\tO\nduring\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ncinacalcet\tB-Chemical\n,\tO\ndose\tO\nadjustment\tO\nmay\tO\nbe\tO\nnecessary\tO\nfor\tO\ndrugs\tO\nthat\tO\ndemonstrate\tO\na\tO\nnarrow\tO\ntherapeutic\tO\nindex\tO\nand\tO\nare\tO\nmetabolized\tO\nby\tO\nCYP2D6\tO\n.\tO\n\nCase\tO\nreport\tO\n:\tO\nacute\tO\nunintentional\tO\ncarbachol\tB-Chemical\nintoxication\tO\n.\tO\n\nINTRODUCTION\tO\n:\tO\nIntoxications\tO\nwith\tO\ncarbachol\tB-Chemical\n,\tO\na\tO\nmuscarinic\tO\ncholinergic\tO\nreceptor\tO\nagonist\tO\nare\tO\nrare\tO\n.\tO\n\nWe\tO\nreport\tO\nan\tO\ninteresting\tO\ncase\tO\ninvestigating\tO\na\tO\n(\tO\nnear\tO\n)\tO\nfatal\tO\npoisoning\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nson\tO\nof\tO\nan\tO\n84\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\ndiscovered\tO\na\tO\nnewspaper\tO\nreport\tO\nstating\tO\nclinical\tO\nsuccess\tO\nwith\tO\nplant\tO\nextracts\tO\nin\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nThe\tO\nmode\tO\nof\tO\naction\tO\nwas\tO\nsaid\tO\nto\tO\nbe\tO\ncomparable\tO\nto\tO\nthat\tO\nof\tO\nthe\tO\nsynthetic\tO\ncompound\tO\n'\tO\ncarbamylcholin\tB-Chemical\n'\tO\n;\tO\nthat\tO\nis\tO\n,\tO\ncarbachol\tB-Chemical\n.\tO\n\nHe\tO\nbought\tO\n25\tO\ng\tO\nof\tO\ncarbachol\tB-Chemical\nas\tO\npure\tO\nsubstance\tO\nin\tO\na\tO\npharmacy\tO\n,\tO\nand\tO\nthe\tO\nfather\tO\nwas\tO\nadministered\tO\n400\tO\nto\tO\n500\tO\nmg\tO\n.\tO\n\nCarbachol\tB-Chemical\nconcentrations\tO\nin\tO\nserum\tO\nand\tO\nurine\tO\non\tO\nday\tO\n1\tO\nand\tO\n2\tO\nof\tO\nhospital\tO\nadmission\tO\nwere\tO\nanalysed\tO\nby\tO\nHPLC\tO\n-\tO\nmass\tO\nspectrometry\tO\n.\tO\n\nRESULTS\tO\n:\tO\nMinutes\tO\nafter\tO\noral\tO\nadministration\tO\n,\tO\nthe\tO\npatient\tO\ndeveloped\tO\nnausea\tB-Disease\n,\tO\nsweating\tO\nand\tO\nhypotension\tB-Disease\n,\tO\nand\tO\nfinally\tO\ncollapsed\tO\n.\tO\n\nBradycardia\tB-Disease\n,\tO\ncholinergic\tO\nsymptoms\tO\nand\tO\nasystole\tB-Disease\noccurred\tO\n.\tO\n\nInitial\tO\ncardiopulmonary\tO\nresuscitation\tO\nand\tO\nimmediate\tO\ntreatment\tO\nwith\tO\nadrenaline\tB-Chemical\n(\tO\nepinephrine\tB-Chemical\n)\tO\n,\tO\natropine\tB-Chemical\nand\tO\nfurosemide\tB-Chemical\nwas\tO\nsuccessful\tO\n.\tO\n\nOn\tO\nhospital\tO\nadmission\tO\n,\tO\nblood\tO\npressure\tO\nof\tO\nthe\tO\nintubated\tO\n,\tO\nbradyarrhythmic\tO\npatient\tO\nwas\tO\n100\tO\n/\tO\n65\tO\nmmHg\tO\n.\tO\n\nFurther\tO\nsigns\tO\nwere\tO\nhyperhidrosis\tB-Disease\n,\tO\nhypersalivation\tB-Disease\n,\tO\nbronchorrhoea\tB-Disease\n,\tO\nand\tO\nsevere\tO\nmiosis\tB-Disease\n;\tO\nthe\tO\nelectrocardiographic\tO\nfinding\tO\nwas\tO\natrio\tB-Disease\n-\tI-Disease\nventricular\tI-Disease\ndissociation\tI-Disease\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\natropine\tB-Chemical\n(\tO\nup\tO\nto\tO\n50\tO\nmg\tO\nper\tO\n24\tO\nhours\tO\n)\tO\n,\tO\nadrenaline\tB-Chemical\nand\tO\ndopamine\tB-Chemical\nwere\tO\nnecessary\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\nextubated\tO\n1\tO\nweek\tO\nlater\tO\n.\tO\n\nHowever\tO\n,\tO\nincreased\tO\ndyspnoea\tB-Disease\nand\tO\nbronchospasm\tB-Disease\nnecessitated\tO\nreintubation\tO\n.\tO\n\nRespiratory\tB-Disease\ninsufficiency\tI-Disease\nwas\tO\nfurther\tO\nworsened\tO\nby\tO\nProteus\tB-Disease\nmirabilis\tI-Disease\ninfection\tI-Disease\nand\tO\nsevere\tO\nbronchoconstriction\tO\n.\tO\n\nOne\tO\nweek\tO\nlater\tO\n,\tO\nthe\tO\npatient\tO\nwas\tO\nagain\tO\nextubated\tO\nand\tO\n3\tO\ndays\tO\nlater\tO\nwas\tO\ntransferred\tO\nto\tO\na\tO\nperipheral\tO\nward\tO\n.\tO\n\nOn\tO\nthe\tO\nnext\tO\nday\tO\nhe\tO\ndied\tO\n,\tO\nprobably\tO\nas\tO\na\tO\nresult\tO\nof\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nSerum\tO\nsamples\tO\nfrom\tO\nthe\tO\nfirst\tO\nand\tO\nsecond\tO\ndays\tO\ncontained\tO\n3\tO\n.\tO\n6\tO\nand\tO\n1\tO\n.\tO\n9\tO\nmg\tO\n/\tO\nl\tO\ncarbachol\tB-Chemical\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\ncorresponding\tO\nurine\tO\nconcentrations\tO\namounted\tO\nto\tO\n374\tO\nand\tO\n554\tO\nmg\tO\n/\tO\nl\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\ncase\tO\nstarted\tO\nwith\tO\na\tO\nmedia\tO\nreport\tO\nin\tO\na\tO\npopular\tO\nnewspaper\tO\n,\tO\ninitiated\tO\nby\tO\npublished\tO\n,\tO\npeer\tO\n-\tO\nreviewed\tO\nresearch\tO\non\tO\nherbals\tO\n,\tO\nand\tO\ninvolved\tO\nhuman\tO\nfailure\tO\nin\tO\na\tO\ncase\tO\nhistory\tO\n,\tO\nmedical\tO\nexamination\tO\nand\tO\nclinical\tO\ntreatment\tO\n.\tO\n\nFor\tO\nthe\tO\nfirst\tO\ntime\tO\n,\tO\nan\tO\nanalytical\tO\nmethod\tO\nfor\tO\nthe\tO\ndetermination\tO\nof\tO\ncarbachol\tB-Chemical\nin\tO\nplasma\tO\nand\tO\nurine\tO\nhas\tO\nbeen\tO\ndeveloped\tO\n.\tO\n\nThe\tO\nanalysed\tO\ncarbachol\tB-Chemical\nconcentration\tO\nexceeded\tO\nthe\tO\nsupposed\tO\nserum\tO\nlevel\tO\nresulting\tO\nfrom\tO\na\tO\ntherapeutic\tO\ndose\tO\nby\tO\na\tO\nfactor\tO\nof\tO\n130\tO\nto\tO\n260\tO\n.\tO\n\nEspecially\tO\nin\tO\nold\tO\npatients\tO\n,\tO\nintensivists\tO\nshould\tO\nconsider\tO\nintoxications\tO\n(\tO\nwith\tO\ncholinergics\tO\n)\tO\nas\tO\na\tO\ncause\tO\nof\tO\nacute\tB-Disease\ncardiovascular\tI-Disease\nfailure\tI-Disease\n.\tO\n\nPharmacological\tO\nevidence\tO\nfor\tO\nthe\tO\npotential\tO\nof\tO\nDaucus\tO\ncarota\tO\nin\tO\nthe\tO\nmanagement\tO\nof\tO\ncognitive\tB-Disease\ndysfunctions\tI-Disease\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\naimed\tO\nat\tO\ninvestigating\tO\nthe\tO\neffects\tO\nof\tO\nDaucus\tO\ncarota\tO\nseeds\tO\non\tO\ncognitive\tO\nfunctions\tO\n,\tO\ntotal\tO\nserum\tO\ncholesterol\tB-Chemical\nlevels\tO\nand\tO\nbrain\tO\ncholinesterase\tO\nactivity\tO\nin\tO\nmice\tO\n.\tO\n\nThe\tO\nethanolic\tO\nextract\tB-Chemical\nof\tI-Chemical\nDaucus\tI-Chemical\ncarota\tI-Chemical\nseeds\tI-Chemical\n(\tO\nDCE\tB-Chemical\n)\tO\nwas\tO\nadministered\tO\norally\tO\nin\tO\nthree\tO\ndoses\tO\n(\tO\n100\tO\n,\tO\n200\tO\n,\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nfor\tO\nseven\tO\nsuccessive\tO\ndays\tO\nto\tO\ndifferent\tO\ngroups\tO\nof\tO\nyoung\tO\nand\tO\naged\tO\nmice\tO\n.\tO\n\nElevated\tO\nplus\tO\nmaze\tO\nand\tO\npassive\tO\navoidance\tO\napparatus\tO\nserved\tO\nas\tO\nthe\tO\nexteroceptive\tO\nbehavioral\tO\nmodels\tO\nfor\tO\ntesting\tO\nmemory\tO\n.\tO\n\nDiazepam\tB-Chemical\n-\tO\n,\tO\nscopolamine\tB-Chemical\n-\tO\nand\tO\nageing\tO\n-\tO\ninduced\tO\namnesia\tB-Disease\nserved\tO\nas\tO\nthe\tO\ninteroceptive\tO\nbehavioral\tO\nmodels\tO\n.\tO\n\nDCE\tB-Chemical\n(\tO\n200\tO\n,\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\nshowed\tO\nsignificant\tO\nimprovement\tO\nin\tO\nmemory\tO\nscores\tO\nof\tO\nyoung\tO\nand\tO\naged\tO\nmice\tO\n.\tO\n\nThe\tO\nextent\tO\nof\tO\nmemory\tO\nimprovement\tO\nevoked\tO\nby\tO\nDCE\tB-Chemical\nwas\tO\n23\tO\n%\tO\nat\tO\nthe\tO\ndose\tO\nof\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\nand\tO\n35\tO\n%\tO\nat\tO\nthe\tO\ndose\tO\nof\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\nin\tO\nyoung\tO\nmice\tO\nusing\tO\nelevated\tO\nplus\tO\nmaze\tO\n.\tO\n\nSimilarly\tO\n,\tO\nsignificant\tO\nimprovements\tO\nin\tO\nmemory\tO\nscores\tO\nwere\tO\nobserved\tO\nusing\tO\npassive\tO\navoidance\tO\napparatus\tO\nand\tO\naged\tO\nmice\tO\n.\tO\n\nFurthermore\tO\n,\tO\nDCE\tB-Chemical\nreversed\tO\nthe\tO\namnesia\tB-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\n(\tO\n0\tO\n.\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nand\tO\ndiazepam\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nDaucus\tB-Chemical\ncarota\tI-Chemical\nextract\tI-Chemical\n(\tO\n200\tO\n,\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\nreduced\tO\nsignificantly\tO\nthe\tO\nbrain\tO\nacetylcholinesterase\tO\nactivity\tO\nand\tO\ncholesterol\tB-Chemical\nlevels\tO\nin\tO\nyoung\tO\nand\tO\naged\tO\nmice\tO\n.\tO\n\nThe\tO\nextent\tO\nof\tO\ninhibition\tO\nof\tO\nbrain\tO\ncholinesterase\tO\nactivity\tO\nevoked\tO\nby\tO\nDCE\tB-Chemical\nat\tO\nthe\tO\ndose\tO\nof\tO\n400\tO\nmg\tO\n/\tO\nkg\tO\nwas\tO\n22\tO\n%\tO\nin\tO\nyoung\tO\nand\tO\n19\tO\n%\tO\nin\tO\naged\tO\nmice\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nremarkable\tO\nreduction\tO\nin\tO\ntotal\tO\ncholesterol\tB-Chemical\nlevel\tO\nas\tO\nwell\tO\n,\tO\nto\tO\nthe\tO\nextent\tO\nof\tO\n23\tO\n%\tO\nin\tO\nyoung\tO\nand\tO\n21\tO\n%\tO\nin\tO\naged\tO\nanimals\tO\nwith\tO\nthis\tO\ndose\tO\nof\tO\nDCE\tB-Chemical\n.\tO\n\nTherefore\tO\n,\tO\nDCE\tB-Chemical\nmay\tO\nprove\tO\nto\tO\nbe\tO\na\tO\nuseful\tO\nremedy\tO\nfor\tO\nthe\tO\nmanagement\tO\nof\tO\ncognitive\tB-Disease\ndysfunctions\tI-Disease\non\tO\naccount\tO\nof\tO\nits\tO\nmultifarious\tO\nbeneficial\tO\neffects\tO\nsuch\tO\nas\tO\n,\tO\nmemory\tO\nimproving\tO\nproperty\tO\n,\tO\ncholesterol\tB-Chemical\nlowering\tO\nproperty\tO\nand\tO\nanticholinesterase\tO\nactivity\tO\n.\tO\n\nValproic\tB-Chemical\nacid\tI-Chemical\ninduced\tO\nencephalopathy\tB-Disease\n-\tO\n-\tO\n19\tO\nnew\tO\ncases\tO\nin\tO\nGermany\tO\nfrom\tO\n1994\tO\nto\tO\n2003\tO\n-\tO\n-\tO\na\tO\nside\tO\neffect\tO\nassociated\tO\nto\tO\nVPA\tB-Chemical\n-\tO\ntherapy\tO\nnot\tO\nonly\tO\nin\tO\nyoung\tO\nchildren\tO\n.\tO\n\nValproic\tB-Chemical\nacid\tI-Chemical\n(\tO\nVPA\tB-Chemical\n)\tO\nis\tO\na\tO\nbroad\tO\n-\tO\nspectrum\tO\nantiepileptic\tO\ndrug\tO\nand\tO\nis\tO\nusually\tO\nwell\tO\n-\tO\ntolerated\tO\n.\tO\n\nRare\tO\nserious\tO\ncomplications\tO\nmay\tO\noccur\tO\nin\tO\nsome\tO\npatients\tO\n,\tO\nincluding\tO\nhaemorrhagic\tO\npancreatitis\tB-Disease\n,\tO\nbone\tB-Disease\nmarrow\tI-Disease\nsuppression\tI-Disease\n,\tO\nVPA\tB-Chemical\n-\tO\ninduced\tO\nhepatotoxicity\tB-Disease\nand\tO\nVPA\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\n.\tO\n\nThe\tO\ntypical\tO\nsigns\tO\nof\tO\nVPA\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\nare\tO\nimpaired\tB-Disease\nconsciousness\tI-Disease\n,\tO\nsometimes\tO\nmarked\tO\nEEG\tO\nbackground\tO\nslowing\tO\n,\tO\nincreased\tO\nseizure\tB-Disease\nfrequency\tO\n,\tO\nwith\tO\nor\tO\nwithout\tO\nhyperammonemia\tB-Disease\n.\tO\n\nThere\tO\nis\tO\nstill\tO\nno\tO\nproof\tO\nof\tO\ncausative\tO\neffect\tO\nof\tO\nVPA\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nencephalopathy\tB-Disease\n,\tO\nbut\tO\nonly\tO\nof\tO\nan\tO\nassociation\tO\nwith\tO\nan\tO\nassumed\tO\ncausal\tO\nrelation\tO\n.\tO\n\nWe\tO\nreport\tO\n19\tO\npatients\tO\nwith\tO\nVPA\tB-Chemical\n-\tO\nassociated\tO\nencephalopathy\tB-Disease\nin\tO\nGermany\tO\nfrom\tO\nthe\tO\nyears\tO\n1994\tO\nto\tO\n2003\tO\n,\tO\nnone\tO\nof\tO\nwhom\tO\nhad\tO\nbeen\tO\npublished\tO\npreviously\tO\n.\tO\n\nCerebral\tB-Disease\nhaemorrhage\tI-Disease\ninduced\tO\nby\tO\nwarfarin\tB-Chemical\n-\tO\nthe\tO\ninfluence\tO\nof\tO\ndrug\tO\n-\tO\ndrug\tO\ninteractions\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nfrequency\tO\n,\tO\nseverity\tO\nand\tO\npreventability\tO\nof\tO\nwarfarin\tB-Chemical\n-\tO\ninduced\tO\ncerebral\tB-Disease\nhaemorrhages\tI-Disease\ndue\tO\nto\tO\nwarfarin\tB-Chemical\nand\tO\nwarfarin\tB-Chemical\n-\tO\ndrug\tO\ninteractions\tO\nin\tO\npatients\tO\nliving\tO\nin\tO\nthe\tO\ncounty\tO\nof\tO\nOsterg\tO\ntland\tO\n,\tO\nSweden\tO\n.\tO\n\nMETHODS\tO\n:\tO\nAll\tO\npatients\tO\nwith\tO\na\tO\ndiagnosed\tO\ncerebral\tB-Disease\nhaemorrhage\tI-Disease\nat\tO\nthree\tO\nhospitals\tO\nduring\tO\nthe\tO\nperiod\tO\n2000\tO\n-\tO\n2002\tO\nwere\tO\nidentified\tO\n.\tO\n\nMedical\tO\nrecords\tO\nwere\tO\nstudied\tO\nretrospectively\tO\nto\tO\nevaluate\tO\nwhether\tO\nwarfarin\tB-Chemical\nand\tO\nwarfarin\tB-Chemical\n-\tO\ndrug\tO\ninteractions\tO\ncould\tO\nhave\tO\ncaused\tO\nthe\tO\ncerebral\tB-Disease\nhaemorrhage\tI-Disease\n.\tO\n\nThe\tO\nproportion\tO\nof\tO\npossibly\tO\navoidable\tO\ncases\tO\ndue\tO\nto\tO\ndrug\tO\ninteractions\tO\nwas\tO\nestimated\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAmong\tO\n593\tO\npatients\tO\nwith\tO\ncerebral\tB-Disease\nhaemorrhage\tI-Disease\n,\tO\n59\tO\n(\tO\n10\tO\n%\tO\n)\tO\nwere\tO\nassessed\tO\nas\tO\nrelated\tO\nto\tO\nwarfarin\tB-Chemical\ntreatment\tO\n.\tO\n\nThis\tO\nimply\tO\nan\tO\nincidence\tO\nof\tO\n1\tO\n.\tO\n7\tO\n/\tO\n100\tO\n,\tO\n000\tO\ntreatment\tO\nyears\tO\n.\tO\n\nOf\tO\nthe\tO\n59\tO\ncases\tO\n,\tO\n26\tO\n(\tO\n44\tO\n%\tO\n)\tO\nhad\tO\na\tO\nfatal\tO\noutcome\tO\n,\tO\ncompared\tO\nto\tO\n136\tO\n(\tO\n25\tO\n%\tO\n)\tO\namong\tO\nthe\tO\nnon\tO\n-\tO\nwarfarin\tB-Chemical\npatients\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nA\tO\nwarfarin\tB-Chemical\n-\tO\ndrug\tO\ninteraction\tO\ncould\tO\nhave\tO\ncontributed\tO\nto\tO\nthe\tO\nhaemorrhage\tB-Disease\nin\tO\n24\tO\n(\tO\n41\tO\n%\tO\n)\tO\nof\tO\nthe\tO\nwarfarin\tB-Chemical\npatients\tO\nand\tO\nin\tO\n7\tO\nof\tO\nthese\tO\n(\tO\n12\tO\n%\tO\n)\tO\nthe\tO\nbleeding\tB-Disease\ncomplication\tO\nwas\tO\nconsidered\tO\nbeing\tO\npossible\tO\nto\tO\navoid\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\ncerebral\tB-Disease\nhaemorrhages\tI-Disease\nare\tO\na\tO\nmajor\tO\nclinical\tO\nproblem\tO\nwith\tO\na\tO\nhigh\tO\nfatality\tO\nrate\tO\n.\tO\n\nAlmost\tO\nhalf\tO\nof\tO\nthe\tO\ncases\tO\nwas\tO\nrelated\tO\nto\tO\na\tO\nwarfarin\tB-Chemical\n-\tO\ndrug\tO\ninteraction\tO\n.\tO\n\nA\tO\nsignificant\tO\nproportion\tO\nof\tO\nwarfarin\tB-Chemical\n-\tO\nrelated\tO\ncerebral\tB-Disease\nhaemorrhages\tI-Disease\nmight\tO\nhave\tO\nbeen\tO\nprevented\tO\nif\tO\ngreater\tO\ncaution\tO\nhad\tO\nbeen\tO\ntaken\tO\nwhen\tO\nprescribing\tO\ndrugs\tO\nknown\tO\nto\tO\ninteract\tO\nwith\tO\nwarfarin\tB-Chemical\n.\tO\n\nAntipsychotic\tO\n-\tO\nlike\tO\nprofile\tO\nof\tO\nthioperamide\tB-Chemical\n,\tO\na\tO\nselective\tO\nH3\tO\n-\tO\nreceptor\tO\nantagonist\tO\nin\tO\nmice\tO\n.\tO\n\nExperimental\tO\nand\tO\nclinical\tO\nevidence\tO\npoints\tO\nto\tO\na\tO\nrole\tO\nof\tO\ncentral\tO\nhistaminergic\tO\nsystem\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nschizophrenia\tB-Disease\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nstudy\tO\nthe\tO\neffect\tO\nof\tO\nhistamine\tB-Chemical\nH\tO\n(\tO\n3\tO\n)\tO\n-\tO\nreceptor\tO\nligands\tO\non\tO\nneuroleptic\tO\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n,\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nclimbing\tO\nbehavior\tO\nand\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nactivities\tO\nin\tO\nmice\tO\n.\tO\n\nCatalepsy\tB-Disease\nwas\tO\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\n,\tO\nwhile\tO\napomorphine\tB-Chemical\n(\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nand\tO\namphetamine\tB-Chemical\n(\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nwere\tO\nused\tO\nfor\tO\nstudying\tO\nclimbing\tO\nbehavior\tO\nand\tO\nlocomotor\tO\nactivities\tO\n,\tO\nrespectively\tO\n.\tO\n\n(\tB-Chemical\nR\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\nmethylhistamine\tI-Chemical\n(\tO\nRAMH\tB-Chemical\n)\tO\n(\tO\n5\tO\nmicrog\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\nand\tO\nthioperamide\tB-Chemical\n(\tO\nTHP\tB-Chemical\n)\tO\n(\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\nper\tO\nse\tO\ndid\tO\nnot\tO\ncause\tO\ncatalepsy\tB-Disease\n.\tO\n\nAdministration\tO\nof\tO\nTHP\tB-Chemical\n(\tO\n3\tO\n.\tO\n75\tO\n,\tO\n7\tO\n.\tO\n5\tO\nand\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n1\tO\nh\tO\nprior\tO\nto\tO\nhaloperidol\tB-Chemical\nresulted\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nincrease\tO\nin\tO\nthe\tO\ncatalepsy\tB-Disease\ntimes\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\npretreatment\tO\nwith\tO\nRAMH\tB-Chemical\nsignificantly\tO\nreversed\tO\nsuch\tO\nan\tO\neffect\tO\nof\tO\nTHP\tB-Chemical\n(\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nRAMH\tB-Chemical\nper\tO\nse\tO\nshowed\tO\nsignificant\tO\nreduction\tO\nin\tO\nlocomotor\tO\ntime\tO\n,\tO\ndistance\tO\ntraveled\tO\nand\tO\naverage\tO\nspeed\tO\nbut\tO\nTHP\tB-Chemical\n(\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nper\tO\nse\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthese\tO\nparameters\tO\n.\tO\n\nOn\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n,\tO\nTHP\tB-Chemical\n(\tO\n3\tO\n.\tO\n75\tO\nand\tO\n7\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nreduced\tO\nlocomotor\tO\ntime\tO\n,\tO\ndistance\tO\ntraveled\tO\nand\tO\naverage\tO\nspeed\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nPretreatment\tO\nwith\tO\nRAMH\tB-Chemical\n(\tO\n5\tO\nmicrog\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\ncould\tO\npartially\tO\nreverse\tO\nsuch\tO\neffects\tO\nof\tO\nTHP\tB-Chemical\n(\tO\n3\tO\n.\tO\n75\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n.\tO\n\nClimbing\tO\nbehavior\tO\ninduced\tO\nby\tO\napomorphine\tB-Chemical\nwas\tO\nreduced\tO\nin\tO\nanimals\tO\ntreated\tO\nwith\tO\nTHP\tB-Chemical\n.\tO\n\nSuch\tO\nan\tO\neffect\tO\nwas\tO\n,\tO\nhowever\tO\n,\tO\nreversed\tO\nin\tO\npresence\tO\nof\tO\nRAMH\tB-Chemical\n.\tO\n\nTHP\tB-Chemical\nexhibited\tO\nan\tO\nantipsychotic\tO\n-\tO\nlike\tO\nprofile\tO\nby\tO\npotentiating\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\n,\tO\nreducing\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nand\tO\nreducing\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nclimbing\tO\nin\tO\nmice\tO\n.\tO\n\nSuch\tO\neffects\tO\nof\tO\nTHP\tB-Chemical\nwere\tO\nreversed\tO\nby\tO\nRAMH\tB-Chemical\nindicating\tO\nthe\tO\ninvolvement\tO\nof\tO\nhistamine\tB-Chemical\nH\tO\n(\tO\n3\tO\n)\tO\n-\tO\nreceptors\tO\n.\tO\n\nFindings\tO\nsuggest\tO\na\tO\npotential\tO\nfor\tO\nH\tO\n(\tO\n3\tO\n)\tO\n-\tO\nreceptor\tO\nantagonists\tO\nin\tO\nimproving\tO\nthe\tO\nrefractory\tO\ncases\tO\nof\tO\nschizophrenia\tB-Disease\n.\tO\n\nCauda\tB-Disease\nequina\tI-Disease\nsyndrome\tI-Disease\nafter\tO\nepidural\tO\nsteroid\tB-Chemical\ninjection\tO\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nConventional\tO\ntreatment\tO\nmethods\tO\nof\tO\nlumbusacral\tO\nradiculopathy\tB-Disease\nare\tO\nphysical\tO\ntherapy\tO\n,\tO\nepidural\tO\nsteroid\tB-Chemical\ninjections\tO\n,\tO\noral\tO\nmedications\tO\n,\tO\nand\tO\nspinal\tO\nmanipulative\tO\ntherapy\tO\n.\tO\n\nCauda\tB-Disease\nequina\tI-Disease\nsyndrome\tI-Disease\nis\tO\na\tO\nrare\tO\ncomplication\tO\nof\tO\nepidural\tO\nanesthesia\tO\n.\tO\n\nThe\tO\nfollowing\tO\ncase\tO\nis\tO\na\tO\nreport\tO\nof\tO\ncauda\tB-Disease\nequina\tI-Disease\nsyndrome\tI-Disease\npossibly\tO\ncaused\tO\nby\tO\nepidural\tO\ninjection\tO\nof\tO\ntriamcinolone\tB-Chemical\nand\tO\nbupivacaine\tB-Chemical\n.\tO\n\nCLINICAL\tO\nFEATURES\tO\n:\tO\nA\tO\n50\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nlow\tB-Disease\nback\tI-Disease\nand\tI-Disease\nright\tI-Disease\nleg\tI-Disease\npain\tI-Disease\nwas\tO\nscheduled\tO\nfor\tO\nepidural\tO\nsteroid\tB-Chemical\ninjection\tO\n.\tO\n\nINTERVENTION\tO\nAND\tO\nOUTCOME\tO\n:\tO\nAn\tO\n18\tO\n-\tO\ngauge\tO\nTouhy\tO\nneedle\tO\nwas\tO\ninserted\tO\nuntil\tO\nloss\tO\nof\tO\nresistance\tO\noccurred\tO\nat\tO\nthe\tO\nL4\tO\n-\tO\n5\tO\nlevel\tO\n.\tO\n\nSpread\tO\nof\tO\nthe\tO\ncontrast\tO\nmedium\tO\nwithin\tO\nthe\tO\nepidural\tO\nspace\tO\nwas\tO\ndetermined\tO\nby\tO\nradiographic\tO\nimaging\tO\n.\tO\n\nAfter\tO\nverifying\tO\nthe\tO\nepidural\tO\nspace\tO\n,\tO\nbupivacaine\tB-Chemical\nand\tO\ntriamcinolone\tB-Chemical\ndiacetate\tI-Chemical\nwere\tO\ninjected\tO\n.\tO\n\nAfter\tO\nthe\tO\ninjection\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nreduction\tO\nin\tO\nradicular\tO\nsymptoms\tO\n.\tO\n\nThree\tO\nhours\tO\nlater\tO\n,\tO\nshe\tO\ncomplained\tO\nof\tO\nperineal\tO\nnumbness\tB-Disease\nand\tO\nlower\tB-Disease\nextremity\tI-Disease\nweakness\tI-Disease\n.\tO\n\nThe\tO\nneurologic\tO\nevaluation\tO\nrevealed\tO\nloss\tB-Disease\nof\tI-Disease\nsensation\tI-Disease\nin\tO\nthe\tO\nsaddle\tO\narea\tO\nand\tO\nmedial\tO\naspect\tO\nof\tO\nher\tO\nright\tO\nleg\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\ndecrease\tO\nin\tO\nthe\tO\nperception\tO\nof\tO\npinprick\tO\ntest\tO\n.\tO\n\nDeep\tO\n-\tO\ntendon\tO\nreflexes\tO\nwere\tO\ndecreased\tO\nespecially\tO\nin\tO\nthe\tO\nright\tO\nleg\tO\n.\tO\n\nShe\tO\nwas\tO\nunable\tO\nto\tO\nurinate\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nsymptoms\tO\nimproved\tO\nslightly\tO\nover\tO\nthe\tO\nnext\tO\nfew\tO\nhours\tO\n.\tO\n\nShe\tO\nhad\tO\na\tO\ngradual\tO\nreturn\tO\nof\tO\nmotor\tO\nfunction\tO\nand\tO\nability\tO\nof\tO\nfeeling\tO\nFoley\tO\ncatheter\tO\n.\tO\n\nAll\tO\nof\tO\nthe\tO\nsymptoms\tO\nwere\tO\ncompletely\tO\nresolved\tO\nover\tO\nthe\tO\nnext\tO\n8\tO\nhours\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nComplications\tO\nassociated\tO\nwith\tO\nepidural\tO\nsteroid\tB-Chemical\ninjections\tO\nare\tO\nrare\tO\n.\tO\n\nClinical\tO\nexamination\tO\nand\tO\ncontinued\tO\nvigilance\tO\nfor\tO\nneurologic\tB-Disease\ndeterioration\tI-Disease\nafter\tO\nepidural\tO\nsteroid\tB-Chemical\ninjections\tO\nis\tO\nimportant\tO\n.\tO\n\nHigh\tO\n-\tO\ndose\tO\ntestosterone\tB-Chemical\nis\tO\nassociated\tO\nwith\tO\natherosclerosis\tB-Disease\nin\tO\npostmenopausal\tO\nwomen\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nstudy\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\neffects\tO\nof\tO\nandrogen\tO\ntreatment\tO\non\tO\natherosclerosis\tB-Disease\nin\tO\npostmenopausal\tO\nwomen\tO\n.\tO\n\nMETHODS\tO\n:\tO\nIn\tO\na\tO\npopulation\tO\n-\tO\nbased\tO\nstudy\tO\nin\tO\n513\tO\nnaturally\tO\npostmenopausal\tO\nwomen\tO\naged\tO\n54\tO\n-\tO\n67\tO\nyears\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nassociation\tO\nbetween\tO\nself\tO\n-\tO\nreported\tO\nintramuscularly\tO\nadministered\tO\nhigh\tO\n-\tO\ndose\tO\nestrogen\tB-Chemical\n-\tO\ntestosterone\tB-Chemical\ntherapy\tO\n(\tO\nestradiol\tB-Chemical\n-\tI-Chemical\nand\tI-Chemical\ntestosterone\tI-Chemical\nesters\tI-Chemical\n)\tO\nand\tO\naortic\tO\natherosclerosis\tB-Disease\n.\tO\n\nAortic\tO\natherosclerosis\tB-Disease\nwas\tO\ndiagnosed\tO\nby\tO\nradiographic\tO\ndetection\tO\nof\tO\ncalcified\tO\ndeposits\tO\nin\tO\nthe\tO\nabdominal\tO\naorta\tO\n,\tO\nwhich\tO\nhave\tO\nbeen\tO\nshown\tO\nto\tO\nreflect\tO\nintima\tO\natherosclerosis\tB-Disease\n.\tO\n\nHormone\tO\ntherapy\tO\nusers\tO\nwere\tO\ncompared\tO\nwith\tO\nnever\tO\nusers\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIntramuscular\tO\nhormone\tO\ntherapy\tO\nuse\tO\nfor\tO\n1\tO\nyear\tO\nor\tO\nlonger\tO\nwas\tO\nreported\tO\nby\tO\n25\tO\nwomen\tO\n.\tO\n\nIn\tO\nalmost\tO\nhalf\tO\nof\tO\nthese\tO\nwomen\tO\nsevere\tO\natherosclerosis\tB-Disease\nof\tO\nthe\tO\naorta\tO\nwas\tO\npresent\tO\n(\tO\nn\tO\n=\tO\n11\tO\n)\tO\n,\tO\nwhile\tO\nin\tO\nwomen\tO\nwithout\tO\nhormone\tO\nuse\tO\nsevere\tO\natherosclerosis\tB-Disease\nof\tO\nthe\tO\naorta\tO\nwas\tO\npresent\tO\nin\tO\nless\tO\nthan\tO\n20\tO\n%\tO\n(\tO\nOR\tO\n3\tO\n.\tO\n1\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n1\tO\n-\tO\n8\tO\n.\tO\n5\tO\n,\tO\nadjusted\tO\nfor\tO\nage\tO\n,\tO\nyears\tO\nsince\tO\nmenopause\tO\n,\tO\nsmoking\tO\n,\tO\nand\tO\nbody\tO\nmass\tO\nindex\tO\n)\tO\n.\tO\n\nThe\tO\nassociation\tO\nremained\tO\nafter\tO\nadditional\tO\nadjustment\tO\nfor\tO\ndiabetes\tB-Disease\n,\tO\ncholesterol\tB-Chemical\nlevel\tO\n,\tO\nsystolic\tO\nblood\tO\npressure\tO\n,\tO\nor\tO\nalcohol\tB-Chemical\nuse\tO\n.\tO\n\nNo\tO\nassociation\tO\nwas\tO\nfound\tO\nfor\tO\nhormone\tO\nuse\tO\nless\tO\nthan\tO\n1\tO\nyear\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\nresults\tO\nsuggest\tO\nthat\tO\nhigh\tO\n-\tO\ndose\tO\ntestosterone\tB-Chemical\ntherapy\tO\nmay\tO\nadversely\tO\naffect\tO\natherosclerosis\tB-Disease\nin\tO\npostmenopausal\tO\nwomen\tO\nand\tO\nindicate\tO\nthat\tO\nandrogen\tO\nreplacement\tO\nin\tO\nthese\tO\nwomen\tO\nmay\tO\nnot\tO\nbe\tO\nharmless\tO\n.\tO\n\nOptimising\tO\nstroke\tB-Disease\nprevention\tO\nin\tO\nnon\tO\n-\tO\nvalvular\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n.\tO\n\nAtrial\tB-Disease\nfibrillation\tI-Disease\nis\tO\nassociated\tO\nwith\tO\nsubstantial\tO\nmorbidity\tO\nand\tO\nmortality\tO\n.\tO\n\nPooled\tO\ndata\tO\nfrom\tO\ntrials\tO\ncomparing\tO\nantithrombotic\tO\ntreatment\tO\nwith\tO\nplacebo\tO\nhave\tO\nshown\tO\nthat\tO\nwarfarin\tB-Chemical\nreduces\tO\nthe\tO\nrisk\tO\nof\tO\nstroke\tB-Disease\nby\tO\n62\tO\n%\tO\n,\tO\nand\tO\nthat\tO\naspirin\tB-Chemical\nalone\tO\nreduces\tO\nthe\tO\nrisk\tO\nby\tO\n22\tO\n%\tO\n.\tO\n\nOverall\tO\n,\tO\nin\tO\nhigh\tO\n-\tO\nrisk\tO\npatients\tO\n,\tO\nwarfarin\tB-Chemical\nis\tO\nsuperior\tO\nto\tO\naspirin\tB-Chemical\nin\tO\npreventing\tO\nstrokes\tB-Disease\n,\tO\nwith\tO\na\tO\nrelative\tO\nrisk\tO\nreduction\tO\nof\tO\n36\tO\n%\tO\n.\tO\n\nXimelagatran\tB-Chemical\n,\tO\nan\tO\noral\tO\ndirect\tO\nthrombin\tO\ninhibitor\tO\n,\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\nas\tO\nefficient\tO\nas\tO\nvitamin\tB-Chemical\nK\tI-Chemical\nantagonist\tO\ndrugs\tO\nin\tO\nthe\tO\nprevention\tO\nof\tO\nembolic\tB-Disease\nevents\tI-Disease\n,\tO\nbut\tO\nhas\tO\nbeen\tO\nrecently\tO\nwithdrawn\tO\nbecause\tO\nof\tO\nabnormal\tB-Disease\nliver\tI-Disease\nfunction\tI-Disease\ntests\tO\n.\tO\n\nThe\tO\nACTIVE\tO\n-\tO\nW\tO\n(\tO\nAtrial\tB-Disease\nFibrillation\tI-Disease\nClopidogrel\tB-Chemical\nTrial\tO\nwith\tO\nIrbesartan\tB-Chemical\nfor\tO\nPrevention\tO\nof\tO\nVascular\tO\nEvents\tO\n)\tO\nstudy\tO\nhas\tO\ndemonstrated\tO\nthat\tO\nwarfarin\tB-Chemical\nis\tO\nsuperior\tO\nto\tO\nplatelet\tO\ntherapy\tO\n(\tO\nclopidogrel\tB-Chemical\nplus\tO\naspirin\tB-Chemical\n)\tO\nin\tO\nthe\tO\nprevention\tO\naf\tO\nembolic\tB-Disease\nevents\tI-Disease\n.\tO\n\nIdraparinux\tB-Chemical\n,\tO\na\tO\nFactor\tO\nXa\tO\ninhibitor\tO\n,\tO\nis\tO\nbeing\tO\nevaluated\tO\nin\tO\npatients\tO\nwith\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n.\tO\n\nAngiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\ninhibitors\tO\nand\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\n-\tO\nblocking\tO\ndrugs\tO\nhold\tO\npromise\tO\nin\tO\natrial\tB-Disease\nfibrillation\tI-Disease\nthrough\tO\ncardiac\tB-Disease\nremodelling\tI-Disease\n.\tO\n\nPreliminary\tO\nstudies\tO\nsuggest\tO\nthat\tO\nstatins\tB-Chemical\ncould\tO\ninterfere\tO\nwith\tO\nthe\tO\nrisk\tO\nof\tO\nrecurrence\tO\nafter\tO\nelectrical\tO\ncardioversion\tO\n.\tO\n\nFinally\tO\n,\tO\npercutaneous\tO\nmethods\tO\nfor\tO\nthe\tO\nexclusion\tO\nof\tO\nleft\tO\natrial\tO\nappendage\tO\nare\tO\nunder\tO\ninvestigation\tO\nin\tO\nhigh\tO\n-\tO\nrisk\tO\npatients\tO\n.\tO\n\nAnti\tO\n-\tO\noxidant\tO\neffects\tO\nof\tO\natorvastatin\tB-Chemical\nin\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\n1\tO\n.\tO\n\nDexamethasone\tB-Chemical\n(\tO\nDex\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nhypertension\tB-Disease\nis\tO\ncharacterized\tO\nby\tO\nendothelial\tO\ndysfunction\tO\nassociated\tO\nwith\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n(\tO\nNO\tB-Chemical\n)\tO\ndeficiency\tO\nand\tO\nincreased\tO\nsuperoxide\tB-Chemical\n(\tO\nO2\tB-Chemical\n-\tI-Chemical\n)\tO\nproduction\tO\n.\tO\n\nAtorvastatin\tB-Chemical\n(\tO\nAto\tB-Chemical\n)\tO\npossesses\tO\npleiotropic\tO\nproperties\tO\nthat\tO\nhave\tO\nbeen\tO\nreported\tO\nto\tO\nimprove\tO\nendothelial\tO\nfunction\tO\nthrough\tO\nincreased\tO\navailability\tO\nof\tO\nNO\tB-Chemical\nand\tO\nreduced\tO\nO2\tB-Chemical\n-\tI-Chemical\nproduction\tO\nin\tO\nvarious\tO\nforms\tO\nof\tO\nhypertension\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nwhether\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n,\tO\nAto\tB-Chemical\ncould\tO\nprevent\tO\nendothelial\tO\nNO\tB-Chemical\nsynthase\tO\n(\tO\neNOS\tO\n)\tO\ndownregulation\tO\nand\tO\nthe\tO\nincrease\tO\nin\tO\nO2\tB-Chemical\n-\tI-Chemical\nin\tO\nSprague\tO\n-\tO\nDawley\tO\n(\tO\nSD\tO\n)\tO\nrats\tO\n,\tO\nthereby\tO\nreducing\tO\nblood\tO\npressure\tO\n.\tO\n\n2\tO\n.\tO\n\nMale\tO\nSD\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n30\tO\n)\tO\nwere\tO\ntreated\tO\nwith\tO\nAto\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\nin\tO\ndrinking\tO\nwater\tO\n)\tO\nor\tO\ntap\tO\nwater\tO\nfor\tO\n15\tO\ndays\tO\n.\tO\n\nDexamethasone\tB-Chemical\n(\tO\n10\tO\nmicrog\tO\n/\tO\nkg\tO\nper\tO\nday\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nor\tO\nsaline\tO\nwas\tO\nstarted\tO\nafter\tO\n4\tO\ndays\tO\nin\tO\nAto\tB-Chemical\n-\tO\ntreated\tO\nand\tO\nnon\tO\n-\tO\ntreated\tO\nrats\tO\nand\tO\ncontinued\tO\nfor\tO\n11\tO\n-\tO\n13\tO\ndays\tO\n.\tO\n\nSystolic\tO\nblood\tO\npressure\tO\n(\tO\nSBP\tO\n)\tO\nwas\tO\nmeasured\tO\non\tO\nalternate\tO\ndays\tO\nusing\tO\nthe\tO\ntail\tO\n-\tO\ncuff\tO\nmethod\tO\n.\tO\n\nEndothelial\tO\nfunction\tO\nwas\tO\nassessed\tO\nby\tO\nacetylcholine\tB-Chemical\n-\tO\ninduced\tO\nvasorelaxation\tO\nand\tO\nphenylephrine\tB-Chemical\n-\tO\ninduced\tO\nvasoconstriction\tO\nin\tO\naortic\tO\nsegments\tO\n.\tO\n\nVascular\tO\neNOS\tO\nmRNA\tO\nwas\tO\nassessed\tO\nby\tO\nsemi\tO\n-\tO\nquantitative\tO\nreverse\tO\ntranscription\tO\n-\tO\npolymerase\tO\nchain\tO\nreaction\tO\n.\tO\n\n3\tO\n.\tO\n\nIn\tO\nrats\tO\ntreated\tO\nwith\tO\nDex\tB-Chemical\nalone\tO\n,\tO\nSBP\tO\nwas\tO\nincreased\tO\nfrom\tO\n109\tO\n+\tO\n/\tO\n-\tO\n2\tO\nto\tO\n133\tO\n+\tO\n/\tO\n-\tO\n2\tO\nmmHg\tO\non\tO\nDays\tO\n4\tO\nand\tO\nDay\tO\n14\tO\n,\tO\nrespectively\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\nAto\tB-Chemical\n+\tO\nDex\tB-Chemical\ngroup\tO\n,\tO\nSBP\tO\nwas\tO\nincreased\tO\nfrom\tO\n113\tO\n+\tO\n/\tO\n-\tO\n2\tO\nto\tO\n119\tO\n+\tO\n/\tO\n-\tO\n2\tO\nmmHg\tO\non\tO\nDays\tO\n4\tO\nto\tO\n14\tO\n,\tO\nrespectively\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nbut\tO\nwas\tO\nsignificantly\tO\nlower\tO\nthan\tO\nSBP\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nDex\tB-Chemical\nalone\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nEndothelial\tO\n-\tO\ndependent\tO\nrelaxation\tO\nand\tO\neNOS\tO\nmRNA\tO\nexpression\tO\nwere\tO\ngreater\tO\nin\tO\nthe\tO\nDex\tB-Chemical\n+\tO\nAto\tB-Chemical\ngroup\tO\nthan\tO\nin\tO\nthe\tO\nDex\tB-Chemical\nonly\tO\ngroup\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\nand\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nAortic\tO\nsuperoxide\tB-Chemical\nproduction\tO\nwas\tO\nlower\tO\nin\tO\nthe\tO\nDex\tB-Chemical\n+\tO\nAto\tB-Chemical\ngroup\tO\ncompared\tO\nwith\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nDex\tB-Chemical\nalone\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\n4\tO\n.\tO\n\nTreatment\tO\nwith\tO\nAto\tB-Chemical\nimproved\tO\nendothelial\tO\nfunction\tO\n,\tO\nreduced\tO\nsuperoxide\tB-Chemical\nproduction\tO\nand\tO\nreduced\tO\nSBP\tO\nin\tO\nDex\tB-Chemical\n-\tO\ntreated\tO\nSD\tO\nrats\tO\n.\tO\n\nSevere\tO\ncitrate\tB-Chemical\ntoxicity\tB-Disease\ncomplicating\tO\nvolunteer\tO\napheresis\tO\nplatelet\tO\ndonation\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nsevere\tO\ncitrate\tB-Chemical\ntoxicity\tB-Disease\nduring\tO\nvolunteer\tO\ndonor\tO\napheresis\tO\nplatelet\tO\ncollection\tO\n.\tO\n\nThe\tO\ndonor\tO\nwas\tO\na\tO\n40\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfemale\tO\n,\tO\nfirst\tO\n-\tO\ntime\tO\napheresis\tO\nplatelet\tO\ndonor\tO\n.\tO\n\nPast\tO\nmedical\tO\nhistory\tO\nwas\tO\nremarkable\tO\nfor\tO\nhypertension\tB-Disease\n,\tO\nhyperlipidemia\tB-Disease\n,\tO\nand\tO\ndepression\tB-Disease\n.\tO\n\nReported\tO\nmedications\tO\nincluded\tO\nbumetanide\tB-Chemical\n,\tO\npravastatin\tB-Chemical\n,\tO\nand\tO\nparoxetine\tB-Chemical\n.\tO\n\nThirty\tO\nminutes\tO\nfrom\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nprocedure\tO\n,\tO\nthe\tO\ndonor\tO\nnoted\tO\ntingling\tO\naround\tO\nthe\tO\nmouth\tO\n,\tO\nhands\tO\n,\tO\nand\tO\nfeet\tO\n.\tO\n\nShe\tO\nthen\tO\nvery\tO\nrapidly\tO\ndeveloped\tO\nacute\tO\nonset\tO\nof\tO\nsevere\tO\nfacial\tO\nand\tO\nextremity\tO\ntetany\tB-Disease\n.\tO\n\nEmpirical\tO\ntreatment\tO\nwith\tO\nintravenous\tO\ncalcium\tB-Chemical\ngluconate\tI-Chemical\nwas\tO\ninitiated\tO\n,\tO\nand\tO\nmuscle\tB-Disease\ncontractions\tI-Disease\nslowly\tO\nsubsided\tO\nover\tO\napproximately\tO\n10\tO\nto\tO\n15\tO\nminutes\tO\n.\tO\n\nThe\tO\nevents\tO\nare\tO\nconsistent\tO\nwith\tO\na\tO\nsevere\tO\nreaction\tO\nto\tO\ncalcium\tB-Chemical\nchelation\tO\nby\tO\nsodium\tB-Chemical\ncitrate\tI-Chemical\nanticoagulant\tO\nresulting\tO\nin\tO\nsymptomatic\tO\nsystemic\tO\nhypocalcemia\tB-Disease\n.\tO\n\nUpon\tO\nadditional\tO\nretrospective\tO\nanalysis\tO\n,\tO\nit\tO\nwas\tO\nnoted\tO\nthat\tO\nbumetanide\tB-Chemical\nis\tO\na\tO\nloop\tB-Chemical\ndiuretic\tI-Chemical\nthat\tO\nmay\tO\ncause\tO\nsignificant\tO\nhypocalcemia\tB-Disease\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\ncareful\tO\nscreening\tO\nfor\tO\nmedications\tO\nand\tO\nunderlying\tO\nconditions\tO\npredisposing\tO\nto\tO\nhypocalcemia\tB-Disease\nis\tO\nrecommended\tO\nto\tO\nhelp\tO\nprevent\tO\nsevere\tO\nreactions\tO\ndue\tO\nto\tO\ncitrate\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nLaboratory\tO\nmeasurement\tO\nof\tO\npre\tO\n-\tO\nprocedure\tO\nserum\tO\ncalcium\tB-Chemical\nlevels\tO\nin\tO\nselected\tO\ndonors\tO\nmay\tO\nidentify\tO\ncases\tO\nrequiring\tO\nheightened\tO\nvigilance\tO\n.\tO\n\nThe\tO\ncase\tO\nalso\tO\nillustrates\tO\nthe\tO\nimportance\tO\nof\tO\nmaintaining\tO\npreparedness\tO\nfor\tO\nmanaging\tO\nrare\tO\nbut\tO\nserious\tO\nreactions\tO\nin\tO\nvolunteer\tO\napheresis\tO\nblood\tO\ndonors\tO\n.\tO\n\nSirolimus\tB-Chemical\n-\tO\nassociated\tO\nproteinuria\tB-Disease\nand\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nSirolimus\tB-Chemical\nis\tO\na\tO\nnovel\tO\nimmunosuppressant\tO\nwith\tO\npotent\tO\nantiproliferative\tO\nactions\tO\nthrough\tO\nits\tO\nability\tO\nto\tO\ninhibit\tO\nthe\tO\nraptor\tO\n-\tO\ncontaining\tO\nmammalian\tO\ntarget\tO\nof\tO\nrapamycin\tB-Chemical\nprotein\tO\nkinase\tO\n.\tO\n\nSirolimus\tB-Chemical\nrepresents\tO\na\tO\nmajor\tO\ntherapeutic\tO\nadvance\tO\nin\tO\nthe\tO\nprevention\tO\nof\tO\nacute\tO\nrenal\tO\nallograft\tO\nrejection\tO\nand\tO\nchronic\tO\nallograft\tO\nnephropathy\tB-Disease\n.\tO\n\nIts\tO\nrole\tO\nin\tO\nthe\tO\ntherapy\tO\nof\tO\nglomerulonephritis\tB-Disease\n,\tO\nautoimmunity\tB-Disease\n,\tO\ncystic\tB-Disease\nrenal\tI-Disease\ndiseases\tI-Disease\nand\tO\nrenal\tB-Disease\ncancer\tI-Disease\nis\tO\nunder\tO\ninvestigation\tO\n.\tO\n\nBecause\tO\nsirolimus\tB-Chemical\ndoes\tO\nnot\tO\nshare\tO\nthe\tO\nvasomotor\tO\nrenal\tO\nadverse\tO\neffects\tO\nexhibited\tO\nby\tO\ncalcineurin\tO\ninhibitors\tO\n,\tO\nit\tO\nhas\tO\nbeen\tO\ndesignated\tO\na\tO\n'\tO\nnon\tO\n-\tO\nnephrotoxic\tB-Disease\ndrug\tO\n'\tO\n.\tO\n\nHowever\tO\n,\tO\nclinical\tO\nreports\tO\nsuggest\tO\nthat\tO\n,\tO\nunder\tO\nsome\tO\ncircumstances\tO\n,\tO\nsirolimus\tB-Chemical\nis\tO\nassociated\tO\nwith\tO\nproteinuria\tB-Disease\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\ndysfunction\tI-Disease\n.\tO\n\nA\tO\ncommon\tO\nrisk\tO\nfactor\tO\nappears\tO\nto\tO\nbe\tO\npresence\tO\nof\tO\npre\tO\n-\tO\nexisting\tO\nchronic\tB-Disease\nrenal\tI-Disease\ndamage\tI-Disease\n.\tO\n\nThe\tO\nmechanisms\tO\nof\tO\nsirolimus\tB-Chemical\n-\tO\nassociated\tO\nproteinuria\tB-Disease\nare\tO\nmultifactorial\tO\nand\tO\nmay\tO\nbe\tO\ndue\tO\nto\tO\nan\tO\nincrease\tO\nin\tO\nglomerular\tO\ncapillary\tO\npressure\tO\nfollowing\tO\ncalcineurin\tO\ninhibitor\tO\nwithdrawal\tO\n.\tO\n\nIt\tO\nhas\tO\nalso\tO\nbeen\tO\nsuggested\tO\nthat\tO\nsirolimus\tB-Chemical\ndirectly\tO\ncauses\tO\nincreased\tO\nglomerular\tO\npermeability\tO\n/\tO\ninjury\tO\n,\tO\nbut\tO\nevidence\tO\nfor\tO\nthis\tO\nmechanism\tO\nis\tO\ncurrently\tO\ninconclusive\tO\n.\tO\n\nThe\tO\nacute\tB-Disease\nrenal\tI-Disease\ndysfunction\tI-Disease\nassociated\tO\nwith\tO\nsirolimus\tB-Chemical\n(\tO\nsuch\tO\nas\tO\nin\tO\ndelayed\tO\ngraft\tO\nfunction\tO\n)\tO\nmay\tO\nbe\tO\ndue\tO\nto\tO\nsuppression\tO\nof\tO\ncompensatory\tO\nrenal\tO\ncell\tO\nproliferation\tO\nand\tO\nsurvival\tO\n/\tO\nrepair\tO\nprocesses\tO\n.\tO\n\nAlthough\tO\nthese\tO\nadverse\tO\neffects\tO\noccur\tO\nin\tO\nsome\tO\npatients\tO\n,\tO\ntheir\tO\noccurrence\tO\ncould\tO\nbe\tO\nminimised\tO\nby\tO\nknowledge\tO\nof\tO\nthe\tO\nmolecular\tO\neffects\tO\nof\tO\nsirolimus\tB-Chemical\non\tO\nthe\tO\nkidney\tO\n,\tO\nthe\tO\nuse\tO\nof\tO\nsirolimus\tB-Chemical\nin\tO\nappropriate\tO\npatient\tO\npopulations\tO\n,\tO\nclose\tO\nmonitoring\tO\nof\tO\nproteinuria\tB-Disease\nand\tO\nrenal\tO\nfunction\tO\n,\tO\nuse\tO\nof\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\ninhibitors\tO\nor\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\nblockers\tO\nif\tO\nproteinuria\tB-Disease\noccurs\tO\nand\tO\nwithdrawal\tO\nif\tO\nneeded\tO\n.\tO\n\nFurther\tO\nlong\tO\n-\tO\nterm\tO\nanalysis\tO\nof\tO\nrenal\tO\nallograft\tO\nstudies\tO\nusing\tO\nsirolimus\tB-Chemical\nas\tO\nde\tO\nnovo\tO\nimmunosuppression\tO\nalong\tO\nwith\tO\nclinical\tO\nand\tO\nlaboratory\tO\nstudies\tO\nwill\tO\nrefine\tO\nthese\tO\nissues\tO\nin\tO\nthe\tO\nfuture\tO\n.\tO\n\nProteinuria\tB-Disease\nafter\tO\nconversion\tO\nto\tO\nsirolimus\tB-Chemical\nin\tO\nrenal\tO\ntransplant\tO\nrecipients\tO\n.\tO\n\nSirolimus\tB-Chemical\n(\tO\nSRL\tB-Chemical\n)\tO\nis\tO\na\tO\nnew\tO\n,\tO\npotent\tO\nimmunosuppressive\tO\nagent\tO\n.\tO\n\nMore\tO\nrecently\tO\n,\tO\nproteinuria\tB-Disease\nhas\tO\nbeen\tO\nreported\tO\nas\tO\na\tO\nconsequence\tO\nof\tO\nsirolimus\tB-Chemical\ntherapy\tO\n,\tO\nalthough\tO\nthe\tO\nmechanism\tO\nhas\tO\nremained\tO\nunclear\tO\n.\tO\n\nWe\tO\nretrospectively\tO\nexamined\tO\nthe\tO\nrecords\tO\nof\tO\n25\tO\nrenal\tO\ntransplant\tO\npatients\tO\n,\tO\nwho\tO\ndeveloped\tO\nor\tO\ndisplayed\tO\nincreased\tO\nproteinuria\tB-Disease\nafter\tO\nSRL\tB-Chemical\nconversion\tO\n.\tO\n\nThe\tO\npatient\tO\ncohort\tO\n(\tO\n14\tO\nmen\tO\n,\tO\n11\tO\nwomen\tO\n)\tO\nwas\tO\ntreated\tO\nwith\tO\nSRL\tB-Chemical\nas\tO\nconversion\tO\ntherapy\tO\n,\tO\ndue\tO\nto\tO\nchronic\tB-Disease\nallograft\tI-Disease\nnephropathy\tI-Disease\n(\tO\nCAN\tB-Disease\n)\tO\n(\tO\nn\tO\n=\tO\n15\tO\n)\tO\nneoplasia\tB-Disease\n(\tO\nn\tO\n=\tO\n8\tO\n)\tO\n;\tO\nKaposi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nsarcoma\tI-Disease\n,\tO\nFour\tO\nskin\tB-Disease\ncancers\tI-Disease\n,\tO\nOne\tO\nintestinal\tB-Disease\ntumors\tI-Disease\n,\tO\nOne\tO\nrenal\tB-Disease\ncell\tI-Disease\ncarsinom\tI-Disease\n)\tO\nor\tO\nBK\tO\nvirus\tO\nnephropathy\tB-Disease\n(\tO\nn\tO\n=\tO\n2\tO\n)\tO\n.\tO\n\nSRL\tB-Chemical\nwas\tO\nstarted\tO\nat\tO\na\tO\nmean\tO\nof\tO\n78\tO\n+\tO\n/\tO\n-\tO\n42\tO\n(\tO\n15\tO\nto\tO\n163\tO\n)\tO\nmonths\tO\nafter\tO\ntransplantation\tO\n.\tO\n\nMean\tO\nfollow\tO\n-\tO\nup\tO\non\tO\nSRL\tB-Chemical\ntherapy\tO\nwas\tO\n20\tO\n+\tO\n/\tO\n-\tO\n12\tO\n(\tO\n6\tO\nto\tO\n43\tO\n)\tO\nmonths\tO\n.\tO\n\nProteinuria\tB-Disease\nincreased\tO\nfrom\tO\n0\tO\n.\tO\n445\tO\n(\tO\n0\tO\nto\tO\n1\tO\n.\tO\n5\tO\n)\tO\ng\tO\n/\tO\nd\tO\nbefore\tO\nconversion\tO\nto\tO\n3\tO\n.\tO\n2\tO\ng\tO\n/\tO\ndL\tO\n(\tO\n0\tO\n.\tO\n2\tO\nto\tO\n12\tO\n)\tO\nafter\tO\nconversion\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nBefore\tO\nconversion\tO\n8\tO\n(\tO\n32\tO\n%\tO\n)\tO\npatients\tO\nhad\tO\nno\tO\nproteinuria\tB-Disease\n,\tO\nwhereas\tO\nafterwards\tO\nall\tO\npatients\tO\nhad\tO\nproteinuria\tB-Disease\n.\tO\n\nIn\tO\n28\tO\n%\tO\nof\tO\npatients\tO\nproteinuria\tB-Disease\nremained\tO\nunchanged\tO\n,\tO\nwhereas\tO\nit\tO\nincreased\tO\nin\tO\n68\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nIn\tO\n40\tO\n%\tO\nit\tO\nincreased\tO\nby\tO\nmore\tO\nthan\tO\n100\tO\n%\tO\n.\tO\n\nTwenty\tO\n-\tO\neight\tO\npercent\tO\nof\tO\npatients\tO\nshowed\tO\nincreased\tO\nproteinuria\tB-Disease\nto\tO\nthe\tO\nnephrotic\tB-Disease\nrange\tO\n.\tO\n\nBiopsies\tO\nperformed\tO\nin\tO\nfive\tO\npatients\tO\nrevealed\tO\nnew\tO\npathological\tO\nchanges\tO\n:\tO\nOne\tO\nmembranoproliferative\tB-Disease\nglomerulopathy\tI-Disease\nand\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\n.\tO\n\nThese\tO\npatients\tO\nshowed\tO\npersistently\tO\ngood\tO\ngraft\tO\nfunction\tO\n.\tO\n\nSerum\tO\ncreatinine\tB-Chemical\nvalues\tO\ndid\tO\nnot\tO\nchange\tO\nsignificantly\tO\n:\tO\n1\tO\n.\tO\n98\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n8\tO\nmg\tO\n/\tO\ndL\tO\nbefore\tO\nSRL\tB-Chemical\ntherapy\tO\nand\tO\n2\tO\n.\tO\n53\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n9\tO\nmg\tO\n/\tO\ndL\tO\nat\tO\nlast\tO\nfollow\tO\n-\tO\nup\tO\n(\tO\nP\tO\n=\tO\n.\tO\n14\tO\n)\tO\n.\tO\n\nFive\tO\ngrafts\tO\nwere\tO\nlost\tO\nand\tO\nthe\tO\npatients\tO\nreturned\tO\nto\tO\ndialysis\tO\n.\tO\n\nFive\tO\npatients\tO\ndisplayed\tO\nCAN\tB-Disease\nand\tO\nKaposi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nsarcoma\tI-Disease\n.\tO\n\nMean\tO\nurinary\tO\nprotein\tO\nof\tO\npatients\tO\nwho\tO\nreturned\tO\nto\tO\ndialysis\tO\nwas\tO\n1\tO\n.\tO\n26\tO\n(\tO\n0\tO\n.\tO\n5\tO\nto\tO\n3\tO\n.\tO\n5\tO\n)\tO\ng\tO\n/\tO\nd\tO\nbefore\tO\nand\tO\n4\tO\n.\tO\n7\tO\n(\tO\n3\tO\nto\tO\n12\tO\n)\tO\ng\tO\n/\tO\nd\tO\nafter\tO\nconversion\tO\n(\tO\nP\tO\n=\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nMean\tO\nserum\tO\ncreatinine\tB-Chemical\nlevel\tO\nbefore\tO\nconversion\tO\nwas\tO\n2\tO\n.\tO\n21\tO\nmg\tO\n/\tO\ndL\tO\nand\tO\nthereafter\tO\n,\tO\n4\tO\n.\tO\n93\tO\nmg\tO\n/\tO\ndL\tO\n(\tO\nP\tO\n=\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nHeavy\tO\nproteinuria\tB-Disease\nwas\tO\ncommon\tO\nafter\tO\nthe\tO\nuse\tO\nof\tO\nSRL\tB-Chemical\nas\tO\nrescue\tO\ntherapy\tO\nfor\tO\nrenal\tO\ntransplantation\tO\n.\tO\n\nTherefore\tO\n,\tO\nconversion\tO\nshould\tO\nbe\tO\nconsidered\tO\nfor\tO\npatients\tO\nwho\tO\nhave\tO\nnot\tO\ndeveloped\tO\nadvanced\tO\nCAN\tB-Disease\nand\tO\nproteinuria\tB-Disease\n.\tO\n\nThe\tO\npossibility\tO\nof\tO\nde\tO\nnovo\tO\nglomerular\tO\npathology\tO\nunder\tO\nSRL\tB-Chemical\ntreatment\tO\nrequires\tO\nfurther\tO\ninvestigation\tO\nby\tO\nrenal\tO\nbiopsy\tO\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\nifosfamide\tB-Chemical\nrenal\tB-Disease\ntoxicity\tI-Disease\nin\tO\nchildren\tO\ntreated\tO\nfor\tO\nmalignant\tB-Disease\nmesenchymal\tI-Disease\ntumors\tI-Disease\n:\tO\nan\tO\nInternational\tO\nSociety\tO\nof\tO\nPediatric\tO\nOncology\tO\nreport\tO\n.\tO\n\nThe\tO\nrenal\tO\nfunction\tO\nof\tO\n74\tO\nchildren\tO\nwith\tO\nmalignant\tB-Disease\nmesenchymal\tI-Disease\ntumors\tI-Disease\nin\tO\ncomplete\tO\nremission\tO\nand\tO\nwho\tO\nhave\tO\nreceived\tO\nthe\tO\nsame\tO\nifosfamide\tB-Chemical\nchemotherapy\tO\nprotocol\tO\n(\tO\nInternational\tO\nSociety\tO\nof\tO\nPediatric\tO\nOncology\tO\nMalignant\tB-Disease\nMesenchymal\tI-Disease\nTumor\tI-Disease\nStudy\tO\n84\tO\n[\tO\nSIOP\tO\nMMT\tO\n84\tO\n]\tO\n)\tO\nwere\tO\nstudied\tO\n1\tO\nyear\tO\nafter\tO\nthe\tO\ncompletion\tO\nof\tO\ntreatment\tO\n.\tO\n\nTotal\tO\ncumulative\tO\ndoses\tO\nwere\tO\n36\tO\nor\tO\n60\tO\ng\tO\n/\tO\nm2\tO\nof\tO\nifosfamide\tB-Chemical\n(\tO\nsix\tO\nor\tO\n10\tO\ncycles\tO\nof\tO\nifosfamide\tB-Chemical\n,\tI-Chemical\nvincristine\tI-Chemical\n,\tI-Chemical\nand\tI-Chemical\ndactinomycin\tI-Chemical\n[\tO\nIVA\tB-Chemical\n]\tO\n)\tO\n.\tO\n\nNone\tO\nof\tO\nthem\tO\nhad\tO\nreceived\tO\ncisplatin\tB-Chemical\nchemotherapy\tO\n.\tO\n\nAges\tO\nranged\tO\nfrom\tO\n4\tO\nmonths\tO\nto\tO\n17\tO\nyears\tO\n;\tO\n58\tO\npatients\tO\nwere\tO\nmales\tO\nand\tO\n42\tO\nfemales\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nprimary\tO\ntumor\tB-Disease\nsite\tO\nwas\tO\nthe\tO\nhead\tO\nand\tO\nneck\tO\n.\tO\n\nRenal\tO\nfunction\tO\nwas\tO\ninvestigated\tO\nby\tO\nmeasuring\tO\nplasma\tO\nand\tO\nurinary\tO\nelectrolytes\tO\n,\tO\nglucosuria\tB-Disease\n,\tO\nproteinuria\tB-Disease\n,\tO\naminoaciduria\tB-Disease\n,\tO\nurinary\tO\npH\tO\n,\tO\nosmolarity\tO\n,\tO\ncreatinine\tB-Chemical\nclearance\tO\n,\tO\nphosphate\tB-Chemical\ntubular\tO\nreabsorption\tO\n,\tO\nbeta\tO\n2\tO\nmicroglobulinuria\tO\n,\tO\nand\tO\nlysozymuria\tO\n.\tO\n\nFifty\tO\n-\tO\neight\tO\npatients\tO\n(\tO\n78\tO\n%\tO\n)\tO\nhad\tO\nnormal\tO\nrenal\tO\ntests\tO\n,\tO\nwhereas\tO\n16\tO\npatients\tO\n(\tO\n22\tO\n%\tO\n)\tO\nhad\tO\nrenal\tB-Disease\nabnormalities\tI-Disease\n.\tO\n\nTwo\tO\nsubsets\tO\nof\tO\npatients\tO\nwere\tO\nidentified\tO\nfrom\tO\nthis\tO\nlatter\tO\ngroup\tO\n:\tO\nthe\tO\nfirst\tO\nincluded\tO\nfour\tO\npatients\tO\n(\tO\n5\tO\n%\tO\nof\tO\nthe\tO\ntotal\tO\npopulation\tO\n)\tO\nwho\tO\ndeveloped\tO\nmajor\tO\ntoxicity\tB-Disease\nresulting\tO\nin\tO\nFanconi\tB-Disease\n'\tI-Disease\ns\tI-Disease\nsyndrome\tI-Disease\n(\tO\nTDFS\tB-Disease\n)\tO\n;\tO\nand\tO\nthe\tO\nsecond\tO\ngroup\tO\nincluded\tO\nfive\tO\npatients\tO\nwith\tO\nelevated\tO\nbeta\tO\n2\tO\nmicroglobulinuria\tO\nand\tO\nlow\tO\nphosphate\tB-Chemical\nreabsorption\tO\n.\tO\n\nThe\tO\nremaining\tO\nseven\tO\npatients\tO\nhad\tO\nisolated\tO\nbeta\tO\n2\tO\nmicroglobulinuria\tO\n.\tO\n\nSevere\tO\ntoxicity\tB-Disease\nwas\tO\ncorrelated\tO\nwith\tO\nthe\tO\nhigher\tO\ncumulative\tO\ndose\tO\nof\tO\n60\tO\ng\tO\n/\tO\nm2\tO\nof\tO\nifosfamide\tB-Chemical\n,\tO\na\tO\nyounger\tO\nage\tO\n(\tO\nless\tO\nthan\tO\n2\tO\n1\tO\n/\tO\n2\tO\nyears\tO\nold\tO\n)\tO\n,\tO\nand\tO\na\tO\npredominance\tO\nof\tO\nvesicoprostatic\tO\ntumor\tB-Disease\ninvolvement\tO\n.\tO\n\nThis\tO\nlow\tO\npercentage\tO\n(\tO\n5\tO\n%\tO\n)\tO\nof\tO\nTDFS\tO\nmust\tO\nbe\tO\nevaluated\tO\nwith\tO\nrespect\tO\nto\tO\nthe\tO\nefficacy\tO\nof\tO\nifosfamide\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nmesenchymal\tB-Disease\ntumors\tI-Disease\nin\tO\nchildren\tO\n.\tO\n\nProgressive\tO\nmyopathy\tB-Disease\nwith\tO\nup\tO\n-\tO\nregulation\tO\nof\tO\nMHC\tO\n-\tO\nI\tO\nassociated\tO\nwith\tO\nstatin\tB-Chemical\ntherapy\tO\n.\tO\n\nStatins\tB-Chemical\ncan\tO\ncause\tO\na\tO\nnecrotizing\tO\nmyopathy\tB-Disease\nand\tO\nhyperCKaemia\tB-Disease\nwhich\tO\nis\tO\nreversible\tO\non\tO\ncessation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nWhat\tO\nis\tO\nless\tO\nwell\tO\nknown\tO\nis\tO\na\tO\nphenomenon\tO\nwhereby\tO\nstatins\tB-Chemical\nmay\tO\ninduce\tO\na\tO\nmyopathy\tB-Disease\n,\tO\nwhich\tO\npersists\tO\nor\tO\nmay\tO\nprogress\tO\nafter\tO\nstopping\tO\nthe\tO\ndrug\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\nmuscle\tO\npathology\tO\nin\tO\n8\tO\nsuch\tO\ncases\tO\n.\tO\n\nAll\tO\nhad\tO\nmyofibre\tO\nnecrosis\tB-Disease\nbut\tO\nonly\tO\n3\tO\nhad\tO\nan\tO\ninflammatory\tO\ninfiltrate\tO\n.\tO\n\nIn\tO\nall\tO\ncases\tO\nthere\tO\nwas\tO\ndiffuse\tO\nor\tO\nmultifocal\tO\nup\tO\n-\tO\nregulation\tO\nof\tO\nMHC\tO\n-\tO\nI\tO\nexpression\tO\neven\tO\nin\tO\nnon\tO\n-\tO\nnecrotic\tB-Disease\nfibres\tO\n.\tO\n\nProgressive\tO\nimprovement\tO\noccurred\tO\nin\tO\n7\tO\ncases\tO\nafter\tO\ncommencement\tO\nof\tO\nprednisolone\tB-Chemical\nand\tO\nmethotrexate\tB-Chemical\n,\tO\nand\tO\nin\tO\none\tO\ncase\tO\nspontaneously\tO\n.\tO\n\nThese\tO\nobservations\tO\nsuggest\tO\nthat\tO\nstatins\tB-Chemical\nmay\tO\ninitiate\tO\nan\tO\nimmune\tO\n-\tO\nmediated\tO\nmyopathy\tB-Disease\nthat\tO\npersists\tO\nafter\tO\nwithdrawal\tO\nof\tO\nthe\tO\ndrug\tO\nand\tO\nresponds\tO\nto\tO\nimmunosuppressive\tO\ntherapy\tO\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\nthis\tO\nmyopathy\tB-Disease\nis\tO\nuncertain\tO\nbut\tO\nmay\tO\ninvolve\tO\nthe\tO\ninduction\tO\nby\tO\nstatins\tB-Chemical\nof\tO\nan\tO\nendoplasmic\tO\nreticulum\tO\nstress\tO\nresponse\tO\nwith\tO\nassociated\tO\nup\tO\n-\tO\nregulation\tO\nof\tO\nMHC\tO\n-\tO\nI\tO\nexpression\tO\nand\tO\nantigen\tO\npresentation\tO\nby\tO\nmuscle\tO\nfibres\tO\n.\tO\n\nUse\tO\nof\tO\nchromosome\tO\nsubstitution\tO\nstrains\tO\nto\tO\nidentify\tO\nseizure\tB-Disease\nsusceptibility\tO\nloci\tO\nin\tO\nmice\tO\n.\tO\n\nSeizure\tB-Disease\nsusceptibility\tO\nvaries\tO\namong\tO\ninbred\tO\nmouse\tO\nstrains\tO\n.\tO\n\nChromosome\tO\nsubstitution\tO\nstrains\tO\n(\tO\nCSS\tO\n)\tO\n,\tO\nin\tO\nwhich\tO\na\tO\nsingle\tO\nchromosome\tO\nfrom\tO\none\tO\ninbred\tO\nstrain\tO\n(\tO\ndonor\tO\n)\tO\nhas\tO\nbeen\tO\ntransferred\tO\nonto\tO\na\tO\nsecond\tO\nstrain\tO\n(\tO\nhost\tO\n)\tO\nby\tO\nrepeated\tO\nbackcrossing\tO\n,\tO\nmay\tO\nbe\tO\nused\tO\nto\tO\nidentify\tO\nquantitative\tO\ntrait\tO\nloci\tO\n(\tO\nQTLs\tO\n)\tO\nthat\tO\ncontribute\tO\nto\tO\nseizure\tB-Disease\nsusceptibility\tO\n.\tO\n\nQTLs\tO\nfor\tO\nsusceptibility\tO\nto\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n,\tO\na\tO\nmodel\tO\nof\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\n,\tO\nhave\tO\nnot\tO\nbeen\tO\nreported\tO\n,\tO\nand\tO\nCSS\tO\nhave\tO\nnot\tO\npreviously\tO\nbeen\tO\nused\tO\nto\tO\nlocalize\tO\nseizure\tB-Disease\nsusceptibility\tO\ngenes\tO\n.\tO\n\nWe\tO\nreport\tO\nQTLs\tO\nidentified\tO\nusing\tO\na\tO\nB6\tO\n(\tO\nhost\tO\n)\tO\nx\tO\nA\tO\n/\tO\nJ\tO\n(\tO\ndonor\tO\n)\tO\nCSS\tO\npanel\tO\nto\tO\nlocalize\tO\ngenes\tO\ninvolved\tO\nin\tO\nsusceptibility\tO\nto\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nThree\tO\nhundred\tO\nfifty\tO\n-\tO\nfive\tO\nadult\tO\nmale\tO\nCSS\tO\nmice\tO\n,\tO\n58\tO\nB6\tO\n,\tO\nand\tO\n39\tO\nA\tO\n/\tO\nJ\tO\nwere\tO\ntested\tO\nfor\tO\nsusceptibility\tO\nto\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nHighest\tO\nstage\tO\nreached\tO\nand\tO\nlatency\tO\nto\tO\neach\tO\nstage\tO\nwere\tO\nrecorded\tO\nfor\tO\nall\tO\nmice\tO\n.\tO\n\nB6\tO\nmice\tO\nwere\tO\nresistant\tO\nto\tO\nseizures\tB-Disease\nand\tO\nslower\tO\nto\tO\nreach\tO\nstages\tO\ncompared\tO\nto\tO\nA\tO\n/\tO\nJ\tO\nmice\tO\n.\tO\n\nThe\tO\nCSS\tO\nfor\tO\nChromosomes\tO\n10\tO\nand\tO\n18\tO\nprogressed\tO\nto\tO\nthe\tO\nmost\tO\nsevere\tO\nstages\tO\n,\tO\ndiverging\tO\ndramatically\tO\nfrom\tO\nthe\tO\nB6\tO\nphenotype\tO\n.\tO\n\nLatencies\tO\nto\tO\nstages\tO\nwere\tO\nalso\tO\nsignificantly\tO\nshorter\tO\nfor\tO\nCSS10\tO\nand\tO\nCSS18\tO\nmice\tO\n.\tO\n\nCSS\tO\nmapping\tO\nsuggests\tO\nseizure\tB-Disease\nsusceptibility\tO\nloci\tO\non\tO\nmouse\tO\nChromosomes\tO\n10\tO\nand\tO\n18\tO\n.\tO\n\nThis\tO\napproach\tO\nprovides\tO\na\tO\nframework\tO\nfor\tO\nidentifying\tO\npotentially\tO\nnovel\tO\nhomologous\tO\ncandidate\tO\ngenes\tO\nfor\tO\nhuman\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\n.\tO\n\nIn\tO\nvitro\tO\ncharacterization\tO\nof\tO\nparasympathetic\tO\nand\tO\nsympathetic\tO\nresponses\tO\nin\tO\ncyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nIn\tO\ncyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\nin\tO\nthe\tO\nrat\tO\n,\tO\ndetrusor\tO\nfunction\tO\nis\tO\nimpaired\tO\nand\tO\nthe\tO\nexpression\tO\nand\tO\neffects\tO\nof\tO\nmuscarinic\tO\nreceptors\tO\naltered\tO\n.\tO\n\nWhether\tO\nor\tO\nnot\tO\nthe\tO\nneuronal\tO\ntransmission\tO\nmay\tO\nbe\tO\naffected\tO\nby\tO\ncystitis\tB-Disease\nwas\tO\npresently\tO\ninvestigated\tO\n.\tO\n\nResponses\tO\nof\tO\nurinary\tO\nstrip\tO\npreparations\tO\nfrom\tO\ncontrol\tO\nand\tO\ncyclophosphamide\tB-Chemical\n-\tO\npretreated\tO\nrats\tO\nto\tO\nelectrical\tO\nfield\tO\nstimulation\tO\nand\tO\nto\tO\nagonists\tO\nwere\tO\nassessed\tO\nin\tO\nthe\tO\nabsence\tO\nand\tO\npresence\tO\nof\tO\nmuscarinic\tO\n,\tO\nadrenergic\tO\nand\tO\npurinergic\tO\nreceptor\tO\nantagonists\tO\n.\tO\n\nGenerally\tO\n,\tO\natropine\tB-Chemical\nreduced\tO\ncontractions\tO\n,\tO\nbut\tO\nin\tO\ncontrast\tO\nto\tO\ncontrols\tO\n,\tO\nit\tO\nalso\tO\nreduced\tO\nresponses\tO\nto\tO\nlow\tO\nelectrical\tO\nfield\tO\nstimulation\tO\nintensity\tO\n(\tO\n1\tO\n-\tO\n5\tO\nHz\tO\n)\tO\nin\tO\ninflamed\tO\npreparations\tO\n.\tO\n\nIn\tO\nboth\tO\ntypes\tO\n,\tO\npurinoceptor\tO\ndesensitization\tO\nwith\tO\nalpha\tB-Chemical\n,\tI-Chemical\nbeta\tI-Chemical\n-\tI-Chemical\nmethylene\tI-Chemical\nadenosine\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\ntriphosphate\tI-Chemical\n(\tO\nalpha\tB-Chemical\n,\tI-Chemical\nbeta\tI-Chemical\n-\tI-Chemical\nmeATP\tI-Chemical\n)\tO\ncaused\tO\nfurther\tO\nreductions\tO\nat\tO\nlow\tO\nfrequencies\tO\n(\tO\n<\tO\n10\tO\nHz\tO\n)\tO\n.\tO\n\nThe\tO\nmuscarinic\tO\nreceptor\tO\nantagonists\tO\natropine\tB-Chemical\n,\tO\n4\tB-Chemical\n-\tI-Chemical\ndiphenylacetoxy\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\nmethylpiperidine\tI-Chemical\n(\tO\n4\tB-Chemical\n-\tI-Chemical\nDAMP\tI-Chemical\n)\tO\n(\tO\n'\tO\nM\tO\n(\tO\n1\tO\n)\tO\n/\tO\nM\tO\n(\tO\n3\tO\n)\tO\n/\tO\nM\tO\n(\tO\n5\tO\n)\tO\n-\tO\nselective\tO\n'\tO\n)\tO\n,\tO\nmethoctramine\tB-Chemical\n(\tO\n'\tO\nM\tO\n(\tO\n2\tO\n)\tO\n-\tO\nselective\tO\n'\tO\n)\tO\nand\tO\npirenzepine\tB-Chemical\n(\tO\n'\tO\nM\tO\n(\tO\n1\tO\n)\tO\n-\tO\nselective\tO\n'\tO\n)\tO\nantagonized\tO\nthe\tO\ntonic\tO\ncomponent\tO\nof\tO\nthe\tO\nelectrical\tO\nfield\tO\nstimulation\tO\n-\tO\nevoked\tO\ncontractile\tO\nresponse\tO\nmore\tO\npotently\tO\nthan\tO\nthe\tO\nphasic\tO\ncomponent\tO\n.\tO\n\n4\tB-Chemical\n-\tI-Chemical\nDAMP\tI-Chemical\ninhibited\tO\nthe\tO\ntonic\tO\ncontractions\tO\nin\tO\ncontrols\tO\nmore\tO\npotently\tO\nthan\tO\nmethoctramine\tB-Chemical\nand\tO\npirenzepine\tB-Chemical\n.\tO\n\nIn\tO\ninflamed\tO\npreparations\tO\n,\tO\nthe\tO\nmuscarinic\tO\nreceptor\tO\nantagonism\tO\non\tO\nthe\tO\nphasic\tO\ncomponent\tO\nof\tO\nthe\tO\nelectrical\tO\nfield\tO\nstimulation\tO\n-\tO\nevoked\tO\ncontraction\tO\nwas\tO\ndecreased\tO\nand\tO\nthe\tO\npirenzepine\tB-Chemical\nand\tO\n4\tB-Chemical\n-\tI-Chemical\nDAMP\tI-Chemical\nantagonism\tO\non\tO\nthe\tO\ntonic\tO\ncomponent\tO\nwas\tO\nmuch\tO\nless\tO\nefficient\tO\nthan\tO\nin\tO\ncontrols\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\ncontrols\tO\n,\tO\nmethoctramine\tB-Chemical\nincreased\tO\n-\tO\n-\tO\ninstead\tO\nof\tO\ndecreased\tO\n-\tO\n-\tO\nthe\tO\ntonic\tO\nresponses\tO\nat\tO\nhigh\tO\nfrequencies\tO\n.\tO\n\nWhile\tO\ncontractions\tO\nto\tO\ncarbachol\tB-Chemical\nand\tO\nATP\tB-Chemical\nwere\tO\nthe\tO\nsame\tO\nin\tO\ninflamed\tO\nand\tO\nin\tO\ncontrol\tO\nstrips\tO\nwhen\tO\nrelated\tO\nto\tO\na\tO\nreference\tO\npotassium\tB-Chemical\nresponse\tO\n,\tO\nisoprenaline\tB-Chemical\n-\tO\ninduced\tO\nrelaxations\tO\nwere\tO\nsmaller\tO\nin\tO\ninflamed\tO\nstrips\tO\n.\tO\n\nThus\tO\n,\tO\nin\tO\ncystitis\tB-Disease\nsubstantial\tO\nchanges\tO\nof\tO\nthe\tO\nefferent\tO\nfunctional\tO\nresponses\tO\noccur\tO\n.\tO\n\nWhile\tO\npostjunctional\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\n-\tO\nmediated\tO\nrelaxations\tO\nare\tO\nreduced\tO\n,\tO\neffects\tO\nby\tO\nprejunctional\tO\ninhibitory\tO\nmuscarinic\tO\nreceptors\tO\nmay\tO\nbe\tO\nincreased\tO\n.\tO\n\nDirect\tO\ninhibition\tO\nof\tO\ncardiac\tO\nhyperpolarization\tO\n-\tO\nactivated\tO\ncyclic\tB-Chemical\nnucleotide\tI-Chemical\n-\tO\ngated\tO\npacemaker\tO\nchannels\tO\nby\tO\nclonidine\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nInhibition\tO\nof\tO\ncardiac\tO\nsympathetic\tO\ntone\tO\nrepresents\tO\nan\tO\nimportant\tO\nstrategy\tO\nfor\tO\ntreatment\tO\nof\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n,\tO\nincluding\tO\narrhythmia\tB-Disease\n,\tO\ncoronary\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n,\tO\nand\tO\nchronic\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nActivation\tO\nof\tO\npresynaptic\tO\nalpha2\tO\n-\tO\nadrenoceptors\tO\nis\tO\nthe\tO\nmost\tO\nwidely\tO\naccepted\tO\nmechanism\tO\nof\tO\naction\tO\nof\tO\nthe\tO\nantisympathetic\tO\ndrug\tO\nclonidine\tB-Chemical\n;\tO\nhowever\tO\n,\tO\nother\tO\ntarget\tO\nproteins\tO\nhave\tO\nbeen\tO\npostulated\tO\nto\tO\ncontribute\tO\nto\tO\nthe\tO\nin\tO\nvivo\tO\nactions\tO\nof\tO\nclonidine\tB-Chemical\n.\tO\n\nMETHODS\tO\nAND\tO\nRESULTS\tO\n:\tO\nTo\tO\ntest\tO\nwhether\tO\nclonidine\tB-Chemical\nelicits\tO\npharmacological\tO\neffects\tO\nindependent\tO\nof\tO\nalpha2\tO\n-\tO\nadrenoceptors\tO\n,\tO\nwe\tO\nhave\tO\ngenerated\tO\nmice\tO\nwith\tO\na\tO\ntargeted\tO\ndeletion\tO\nof\tO\nall\tO\n3\tO\nalpha2\tO\n-\tO\nadrenoceptor\tO\nsubtypes\tO\n(\tO\nalpha2ABC\tO\n-\tO\n/\tO\n-\tO\n)\tO\n.\tO\n\nAlpha2ABC\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nwere\tO\ncompletely\tO\nunresponsive\tO\nto\tO\nthe\tO\nanalgesic\tO\nand\tO\nhypnotic\tO\neffects\tO\nof\tO\nclonidine\tB-Chemical\n;\tO\nhowever\tO\n,\tO\nclonidine\tB-Chemical\nsignificantly\tO\nlowered\tO\nheart\tO\nrate\tO\nin\tO\nalpha2ABC\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nby\tO\nup\tO\nto\tO\n150\tO\nbpm\tO\n.\tO\n\nClonidine\tB-Chemical\n-\tO\ninduced\tO\nbradycardia\tB-Disease\nin\tO\nconscious\tO\nalpha2ABC\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nwas\tO\n32\tO\n.\tO\n3\tO\n%\tO\n(\tO\n10\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\nand\tO\n26\tO\n.\tO\n6\tO\n%\tO\n(\tO\n100\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\nof\tO\nthe\tO\neffect\tO\nin\tO\nwild\tO\n-\tO\ntype\tO\nmice\tO\n.\tO\n\nA\tO\nsimilar\tO\nbradycardic\tO\neffect\tO\nof\tO\nclonidine\tB-Chemical\nwas\tO\nobserved\tO\nin\tO\nisolated\tO\nspontaneously\tO\nbeating\tO\nright\tO\natria\tO\nfrom\tO\nalpha2ABC\tO\n-\tO\nknockout\tO\nand\tO\nwild\tO\n-\tO\ntype\tO\nmice\tO\n.\tO\n\nClonidine\tB-Chemical\ninhibited\tO\nthe\tO\nnative\tO\npacemaker\tO\ncurrent\tO\n(\tO\nI\tO\n(\tO\nf\tO\n)\tO\n)\tO\nin\tO\nisolated\tO\nsinoatrial\tO\nnode\tO\npacemaker\tO\ncells\tO\nand\tO\nthe\tO\nI\tO\n(\tO\nf\tO\n)\tO\n-\tO\ngenerating\tO\nhyperpolarization\tO\n-\tO\nactivated\tO\ncyclic\tB-Chemical\nnucleotide\tI-Chemical\n-\tO\ngated\tO\n(\tO\nHCN\tO\n)\tO\n2\tO\nand\tO\nHCN4\tO\nchannels\tO\nin\tO\ntransfected\tO\nHEK293\tO\ncells\tO\n.\tO\n\nAs\tO\na\tO\nconsequence\tO\nof\tO\nblocking\tO\nI\tO\n(\tO\nf\tO\n)\tO\n,\tO\nclonidine\tB-Chemical\nreduced\tO\nthe\tO\nslope\tO\nof\tO\nthe\tO\ndiastolic\tO\ndepolarization\tO\nand\tO\nthe\tO\nfrequency\tO\nof\tO\npacemaker\tO\npotentials\tO\nin\tO\nsinoatrial\tO\nnode\tO\ncells\tO\nfrom\tO\nwild\tO\n-\tO\ntype\tO\nand\tO\nalpha2ABC\tO\n-\tO\nknockout\tO\nmice\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDirect\tO\ninhibition\tO\nof\tO\ncardiac\tO\nHCN\tO\npacemaker\tO\nchannels\tO\ncontributes\tO\nto\tO\nthe\tO\nbradycardic\tO\neffects\tO\nof\tO\nclonidine\tB-Chemical\ngene\tO\n-\tO\ntargeted\tO\nmice\tO\nin\tO\nvivo\tO\n,\tO\nand\tO\nthus\tO\n,\tO\nclonidine\tB-Chemical\n-\tO\nlike\tO\ndrugs\tO\nrepresent\tO\nnovel\tO\nstructures\tO\nfor\tO\nfuture\tO\nHCN\tO\nchannel\tO\ninhibitors\tO\n.\tO\n\nGranulomatous\tB-Disease\nhepatitis\tI-Disease\ndue\tO\nto\tO\ncombination\tB-Chemical\nof\tI-Chemical\namoxicillin\tI-Chemical\nand\tI-Chemical\nclavulanic\tI-Chemical\nacid\tI-Chemical\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\npatient\tO\nwith\tO\namoxicillin\tB-Chemical\n-\tI-Chemical\nclavulanic\tI-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nhepatitis\tB-Disease\nwith\tO\nhistologic\tO\nmultiple\tO\ngranulomas\tB-Disease\n.\tO\n\nThis\tO\ntype\tO\nof\tO\nlesion\tO\nbroadens\tO\nthe\tO\nspectrum\tO\nof\tO\nliver\tB-Disease\ninjury\tI-Disease\ndue\tO\nto\tO\nthis\tO\ndrug\tO\ncombination\tO\n,\tO\nmainly\tO\nrepresented\tO\nby\tO\na\tO\nbenign\tO\ncholestatic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\nassociation\tO\nof\tO\ngranulomas\tB-Disease\nand\tO\neosinophilia\tB-Disease\nfavor\tO\nan\tO\nimmunoallergic\tO\nmechanism\tO\n.\tO\n\nAs\tO\npenicillin\tB-Chemical\nderivatives\tO\nand\tO\namoxicillin\tB-Chemical\nalone\tO\nare\tO\nknown\tO\nto\tO\ninduce\tO\nsuch\tO\ntypes\tO\nof\tO\nlesions\tO\n,\tO\nthe\tO\namoxicillin\tB-Chemical\ncomponent\tO\n,\tO\nwith\tO\nor\tO\nwithout\tO\na\tO\npotentiating\tO\neffect\tO\nof\tO\nclavulanic\tB-Chemical\nacid\tI-Chemical\n,\tO\nmight\tO\nhave\tO\na\tO\nmajor\tO\nrole\tO\n.\tO\n\nDobutamine\tB-Chemical\nstress\tO\nechocardiography\tO\n:\tO\na\tO\nsensitive\tO\nindicator\tO\nof\tO\ndiminished\tO\nmyocardial\tO\nfunction\tO\nin\tO\nasymptomatic\tO\ndoxorubicin\tB-Chemical\n-\tO\ntreated\tO\nlong\tO\n-\tO\nterm\tO\nsurvivors\tO\nof\tO\nchildhood\tO\ncancer\tB-Disease\n.\tO\n\nDoxorubicin\tB-Chemical\nis\tO\nan\tO\neffective\tO\nanticancer\tO\nchemotherapeutic\tO\nagent\tO\nknown\tO\nto\tO\ncause\tO\nacute\tO\nand\tO\nchronic\tO\ncardiomyopathy\tB-Disease\n.\tO\n\nTo\tO\ndevelop\tO\na\tO\nmore\tO\nsensitive\tO\nechocardiographic\tO\nscreening\tO\ntest\tO\nfor\tO\ncardiac\tB-Disease\ndamage\tI-Disease\ndue\tO\nto\tO\ndoxorubicin\tB-Chemical\n,\tO\na\tO\ncohort\tO\nstudy\tO\nwas\tO\nperformed\tO\nusing\tO\ndobutamine\tB-Chemical\ninfusion\tO\nto\tO\ndifferentiate\tO\nasymptomatic\tO\nlong\tO\n-\tO\nterm\tO\nsurvivors\tO\nof\tO\nchildhood\tO\ncancer\tB-Disease\ntreated\tO\nwith\tO\ndoxorubicin\tB-Chemical\nfrom\tO\nhealthy\tO\ncontrol\tO\nsubjects\tO\n.\tO\n\nEchocardiographic\tO\ndata\tO\nfrom\tO\nthe\tO\nexperimental\tO\ngroup\tO\nof\tO\n21\tO\npatients\tO\n(\tO\nmean\tO\nage\tO\n16\tO\n+\tO\n/\tO\n-\tO\n5\tO\nyears\tO\n)\tO\ntreated\tO\nfrom\tO\n1\tO\n.\tO\n6\tO\nto\tO\n14\tO\n.\tO\n3\tO\nyears\tO\n(\tO\nmedian\tO\n5\tO\n.\tO\n3\tO\n)\tO\nbefore\tO\nthis\tO\nstudy\tO\nwith\tO\n27\tO\nto\tO\n532\tO\nmg\tO\n/\tO\nm2\tO\nof\tO\ndoxorubicin\tB-Chemical\n(\tO\nmean\tO\n196\tO\n)\tO\nwere\tO\ncompared\tO\nwith\tO\nechocardiographic\tO\ndata\tO\nfrom\tO\n12\tO\nnormal\tO\nage\tO\n-\tO\nmatched\tO\ncontrol\tO\nsubjects\tO\n.\tO\n\nGraded\tO\ndobutamine\tB-Chemical\ninfusions\tO\nof\tO\n0\tO\n.\tO\n5\tO\n,\tO\n2\tO\n.\tO\n5\tO\n,\tO\n5\tO\nand\tO\n10\tO\nmicrograms\tO\n/\tO\nkg\tO\nper\tO\nmin\tO\nwere\tO\nadministered\tO\n.\tO\n\nEchocardiographic\tO\nDoppler\tO\nstudies\tO\nwere\tO\nperformed\tO\nbefore\tO\ninfusion\tO\nand\tO\nafter\tO\n15\tO\nmin\tO\nof\tO\ninfusion\tO\nat\tO\neach\tO\nrate\tO\n.\tO\n\nDobutamine\tB-Chemical\ninfusion\tO\nat\tO\n10\tO\nmicrograms\tO\n/\tO\nkg\tO\nper\tO\nmin\tO\nwas\tO\ndiscontinued\tO\nafter\tO\nsix\tO\nstudies\tO\nsecondary\tO\nto\tO\na\tO\n50\tO\n%\tO\nincidence\tO\nrate\tO\nof\tO\nadverse\tO\nsymptoms\tO\n.\tO\n\nThe\tO\nmost\tO\nimportant\tO\nfindings\tO\nwere\tO\nthat\tO\ncompared\tO\nwith\tO\nvalues\tO\nin\tO\ncontrol\tO\nsubjects\tO\n,\tO\nend\tO\n-\tO\nsystolic\tO\nleft\tO\nventricular\tO\nposterior\tO\nwall\tO\ndimension\tO\nand\tO\npercent\tO\nof\tO\nleft\tO\nventricular\tO\nposterior\tO\nwall\tO\nthickening\tO\nin\tO\ndoxorubicin\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nwere\tO\ndecreased\tO\nat\tO\nbaseline\tO\nstudy\tO\nand\tO\nthese\tO\nfindings\tO\nwere\tO\nmore\tO\nclearly\tO\ndelineated\tO\nwith\tO\ndobutamine\tB-Chemical\nstimulation\tO\n.\tO\n\nEnd\tO\n-\tO\nsystolic\tO\nleft\tO\nventricular\tO\nposterior\tO\nwall\tO\ndimension\tO\nat\tO\nbaseline\tO\nfor\tO\nthe\tO\ndoxorubicin\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\nwas\tO\n11\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n9\tO\nmm\tO\nversus\tO\n13\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n5\tO\nmm\tO\nfor\tO\ncontrol\tO\nsubjects\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nEnd\tO\n-\tO\nsystolic\tO\nleft\tO\nventricular\tO\nposterior\tO\nwall\tO\ndimension\tO\nat\tO\nthe\tO\n5\tO\n-\tO\nmicrograms\tO\n/\tO\nkg\tO\nper\tO\nmin\tO\ndobutamine\tB-Chemical\ninfusion\tO\nfor\tO\nthe\tO\ndoxorubicin\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\nwas\tO\n14\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n4\tO\nmm\tO\nversus\tO\n19\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n6\tO\nmm\tO\nfor\tO\ncontrol\tO\nsubjects\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nInfluence\tO\nof\tO\nsmoking\tB-Chemical\non\tO\ndeveloping\tO\ncochlea\tO\n.\tO\n\nDoes\tO\nsmoking\tB-Chemical\nduring\tO\npregnancy\tO\naffect\tO\nthe\tO\namplitudes\tO\nof\tO\ntransient\tO\nevoked\tO\notoacoustic\tO\nemissions\tO\nin\tO\nnewborns\tO\n?\tO\n\nOBJECTIVE\tO\n:\tO\nMaternal\tO\ntobacco\tO\nsmoking\tB-Chemical\nhas\tO\nnegative\tO\neffects\tO\non\tO\nfetal\tO\ngrowth\tO\n.\tO\n\nThe\tO\ninfluence\tO\nof\tO\nsmoking\tB-Chemical\nduring\tO\npregnancy\tO\non\tO\nthe\tO\ndeveloping\tO\ncochlea\tO\nhas\tO\nnot\tO\nbeen\tO\nestimated\tO\n,\tO\nalthough\tO\nsmoking\tB-Chemical\nhas\tO\nbeen\tO\npositively\tO\nassociated\tO\nwith\tO\nhearing\tB-Disease\nloss\tI-Disease\nin\tO\nadults\tO\n.\tO\n\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\neffects\tO\nof\tO\nmaternal\tO\nsmoking\tB-Chemical\non\tO\ntransient\tO\nevoked\tO\notoacoustic\tO\nemissions\tO\n(\tO\nTEOAEs\tO\n)\tO\nof\tO\nhealthy\tO\nneonates\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\nstudy\tO\nwas\tO\nundertaken\tO\nas\tO\npart\tO\nof\tO\nneonatal\tO\nscreening\tO\nfor\tO\nhearing\tB-Disease\nimpairment\tI-Disease\nand\tO\ninvolved\tO\nboth\tO\nears\tO\nof\tO\n200\tO\nnewborns\tO\n.\tO\n\nNewborns\tO\nwhose\tO\nmothers\tO\nreported\tO\nsmoking\tB-Chemical\nduring\tO\npregnancy\tO\n(\tO\nn\tO\n=\tO\n200\tO\nears\tO\n)\tO\nwere\tO\ncompared\tO\nto\tO\na\tO\ncontrol\tO\ngroup\tO\nof\tO\nnewborns\tO\n(\tO\nn\tO\n=\tO\n200\tO\nears\tO\n)\tO\n,\tO\nwhose\tO\nmothers\tO\nwere\tO\nnon\tO\n-\tO\nsmokers\tO\n.\tO\n\nExposure\tO\nto\tO\ntobacco\tO\nwas\tO\ncharacterized\tO\nas\tO\nlow\tO\n(\tO\n<\tO\n5\tO\ncigarettes\tO\nper\tO\nday\tO\n,\tO\nn\tO\n=\tO\n88\tO\nears\tO\n)\tO\n,\tO\nmoderate\tO\n(\tO\n5\tO\n<\tO\nor\tO\n=\tO\ncigarettes\tO\nper\tO\nday\tO\n<\tO\n10\tO\n,\tO\nn\tO\n=\tO\n76\tO\n)\tO\nor\tO\nhigh\tO\n(\tO\n>\tO\nor\tO\n=\tO\n10\tO\ncigarettes\tO\nper\tO\nday\tO\n,\tO\nn\tO\n=\tO\n36\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nIn\tO\nexposed\tO\nneonates\tO\n,\tO\nTEOAEs\tO\nmean\tO\nresponse\tO\n(\tO\nacross\tO\nfrequency\tO\n)\tO\nand\tO\nmean\tO\namplitude\tO\nat\tO\n4000Hz\tO\nwas\tO\nsignificantly\tO\nlower\tO\nthan\tO\nin\tO\nnon\tO\n-\tO\nexposed\tO\nneonates\tO\n.\tO\n\nComparisons\tO\nbetween\tO\nexposed\tO\nnewborns\tO\n'\tO\nsubgroups\tO\nrevealed\tO\nno\tO\nsignificant\tO\ndifferences\tO\n.\tO\n\nHowever\tO\n,\tO\nby\tO\ncomparing\tO\neach\tO\nsubgroup\tO\nto\tO\ncontrol\tO\ngroup\tO\n,\tO\nwe\tO\nfound\tO\nstatistically\tO\nsignificant\tO\ndecreases\tB-Disease\nof\tI-Disease\nTEOAEs\tI-Disease\namplitudes\tI-Disease\nat\tO\n4000Hz\tO\nfor\tO\nall\tO\nthree\tO\ngroups\tO\n.\tO\n\nMean\tO\nTEOAEs\tO\nresponses\tO\nof\tO\nhighly\tO\nexposed\tO\nnewborns\tO\nwere\tO\nalso\tO\nsignificantly\tO\nlower\tO\nin\tO\ncomparison\tO\nto\tO\nour\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\nutero\tO\n,\tO\nexposure\tO\nto\tO\ntobacco\tO\nsmoking\tB-Chemical\nseems\tO\nto\tO\nhave\tO\na\tO\nsmall\tO\nimpact\tO\non\tO\nouter\tO\nhair\tO\ncells\tO\n.\tO\n\nThese\tO\neffects\tO\nseem\tO\nto\tO\nbe\tO\nequally\tO\ntrue\tO\nfor\tO\nall\tO\nexposed\tO\nnewborns\tO\n,\tO\nregardless\tO\nof\tO\nthe\tO\ndegree\tO\nof\tO\nexposure\tO\n.\tO\n\nFurther\tO\nstudies\tO\nare\tO\nneeded\tO\nin\tO\norder\tO\nto\tO\nestablish\tO\na\tO\npotential\tO\nnegative\tO\neffect\tO\nof\tO\nmaternal\tO\nsmoking\tB-Chemical\non\tO\nthe\tO\nneonate\tO\n'\tO\ns\tO\nhearing\tO\nacuity\tO\n.\tO\n\nSimvastatin\tB-Chemical\n-\tO\ninduced\tO\nbilateral\tO\nleg\tO\ncompartment\tB-Disease\nsyndrome\tI-Disease\nand\tO\nmyonecrosis\tB-Disease\nassociated\tO\nwith\tO\nhypothyroidism\tB-Disease\n.\tO\n\nA\tO\n54\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nhypothyroid\tB-Disease\nmale\tO\ntaking\tO\nthyroxine\tB-Chemical\nand\tO\nsimvastatin\tB-Chemical\npresented\tO\nwith\tO\nbilateral\tO\nleg\tO\ncompartment\tB-Disease\nsyndrome\tI-Disease\nand\tO\nmyonecrosis\tB-Disease\n.\tO\n\nUrgent\tO\nfasciotomies\tO\nwere\tO\nperformed\tO\nand\tO\nthe\tO\npatient\tO\nmade\tO\nan\tO\nuneventful\tO\nrecovery\tO\nwith\tO\nthe\tO\nwithdrawal\tO\nof\tO\nsimvastatin\tB-Chemical\n.\tO\n\nIt\tO\nis\tO\nlikely\tO\nthat\tO\nthis\tO\ncomplication\tO\nwill\tO\nbe\tO\nseen\tO\nmore\tO\noften\tO\nwith\tO\nthe\tO\nincreased\tO\nworldwide\tO\nuse\tO\nof\tO\nthis\tO\ndrug\tO\nand\tO\nits\tO\napproval\tO\nfor\tO\nall\tO\narteriopathic\tB-Disease\npatients\tO\n.\tO\n\nNeuroinflammation\tB-Disease\nand\tO\nbehavioral\tB-Disease\nabnormalities\tI-Disease\nafter\tO\nneonatal\tO\nterbutaline\tB-Chemical\ntreatment\tO\nin\tO\nrats\tO\n:\tO\nimplications\tO\nfor\tO\nautism\tB-Disease\n.\tO\n\nAutism\tB-Disease\nis\tO\na\tO\nneurodevelopmental\tB-Disease\ndisorder\tI-Disease\npresenting\tO\nbefore\tO\n3\tO\nyears\tO\nof\tO\nage\tO\nwith\tO\ndeficits\tB-Disease\nin\tI-Disease\ncommunication\tI-Disease\nand\tI-Disease\nsocial\tI-Disease\nskills\tI-Disease\nand\tO\nrepetitive\tB-Disease\nbehaviors\tI-Disease\n.\tO\n\nIn\tO\naddition\tO\nto\tO\ngenetic\tO\ninfluences\tO\n,\tO\nrecent\tO\nstudies\tO\nsuggest\tO\nthat\tO\nprenatal\tO\ndrug\tO\nor\tO\nchemical\tO\nexposures\tO\nare\tO\nrisk\tO\nfactors\tO\nfor\tO\nautism\tB-Disease\n.\tO\n\nTerbutaline\tB-Chemical\n,\tO\na\tO\nbeta2\tO\n-\tO\nadrenoceptor\tO\nagonist\tO\nused\tO\nto\tO\narrest\tO\npreterm\tB-Disease\nlabor\tI-Disease\n,\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nincreased\tO\nconcordance\tO\nfor\tO\nautism\tB-Disease\nin\tO\ndizygotic\tO\ntwins\tO\n.\tO\n\nWe\tO\nstudied\tO\nthe\tO\neffects\tO\nof\tO\nterbutaline\tB-Chemical\non\tO\nmicroglial\tO\nactivation\tO\nin\tO\ndifferent\tO\nbrain\tO\nregions\tO\nand\tO\nbehavioral\tO\noutcomes\tO\nin\tO\ndeveloping\tO\nrats\tO\n.\tO\n\nNewborn\tO\nrats\tO\nwere\tO\ngiven\tO\nterbutaline\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ndaily\tO\non\tO\npostnatal\tO\ndays\tO\n(\tO\nPN\tO\n)\tO\n2\tO\nto\tO\n5\tO\nor\tO\nPN\tO\n11\tO\nto\tO\n14\tO\nand\tO\nexamined\tO\n24\tO\nh\tO\nafter\tO\nthe\tO\nlast\tO\ndose\tO\nand\tO\nat\tO\nPN\tO\n30\tO\n.\tO\n\nImmunohistochemical\tO\nstudies\tO\nshowed\tO\nthat\tO\nadministration\tO\nof\tO\nterbutaline\tB-Chemical\non\tO\nPN\tO\n2\tO\nto\tO\n5\tO\nproduced\tO\na\tO\nrobust\tO\nincrease\tO\nin\tO\nmicroglial\tO\nactivation\tO\non\tO\nPN\tO\n30\tO\nin\tO\nthe\tO\ncerebral\tO\ncortex\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nin\tO\ncerebellar\tO\nand\tO\ncerebrocortical\tO\nwhite\tO\nmatter\tO\n.\tO\n\nNone\tO\nof\tO\nthese\tO\neffects\tO\noccurred\tO\nin\tO\nanimals\tO\ngiven\tO\nterbutaline\tB-Chemical\non\tO\nPN\tO\n11\tO\nto\tO\n14\tO\n.\tO\n\nIn\tO\nbehavioral\tO\ntests\tO\n,\tO\nanimals\tO\ntreated\tO\nwith\tO\nterbutaline\tB-Chemical\non\tO\nPN\tO\n2\tO\nto\tO\n5\tO\nshowed\tO\nconsistent\tO\npatterns\tO\nof\tO\nhyper\tO\n-\tO\nreactivity\tO\nto\tO\nnovelty\tO\nand\tO\naversive\tO\nstimuli\tO\nwhen\tO\nassessed\tO\nin\tO\na\tO\nnovel\tO\nopen\tO\nfield\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nin\tO\nthe\tO\nacoustic\tO\nstartle\tO\nresponse\tO\ntest\tO\n.\tO\n\nOur\tO\nfindings\tO\nindicate\tO\nthat\tO\nbeta2\tO\n-\tO\nadrenoceptor\tO\noverstimulation\tO\nduring\tO\nan\tO\nearly\tO\ncritical\tO\nperiod\tO\nresults\tO\nin\tO\nmicroglial\tO\nactivation\tO\nassociated\tO\nwith\tO\ninnate\tO\nneuroinflammatory\tO\npathways\tO\nand\tO\nbehavioral\tB-Disease\nabnormalities\tI-Disease\n,\tO\nsimilar\tO\nto\tO\nthose\tO\ndescribed\tO\nin\tO\nautism\tB-Disease\n.\tO\n\nThis\tO\nstudy\tO\nprovides\tO\na\tO\nuseful\tO\nanimal\tO\nmodel\tO\nfor\tO\nunderstanding\tO\nthe\tO\nneuropathological\tO\nprocesses\tO\nunderlying\tO\nautism\tB-Disease\nspectrum\tI-Disease\ndisorders\tI-Disease\n.\tO\n\nUpregulation\tO\nof\tO\nbrain\tO\nexpression\tO\nof\tO\nP\tO\n-\tO\nglycoprotein\tO\nin\tO\nMRP2\tO\n-\tO\ndeficient\tO\nTR\tO\n(\tO\n-\tO\n)\tO\nrats\tO\nresembles\tO\nseizure\tB-Disease\n-\tO\ninduced\tO\nup\tO\n-\tO\nregulation\tO\nof\tO\nthis\tO\ndrug\tO\nefflux\tO\ntransporter\tO\nin\tO\nnormal\tO\nrats\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nThe\tO\nmultidrug\tO\nresistance\tO\nprotein\tO\n2\tO\n(\tO\nMRP2\tO\n)\tO\nis\tO\na\tO\ndrug\tO\nefflux\tO\ntransporter\tO\nthat\tO\nis\tO\nexpressed\tO\npredominantly\tO\nat\tO\nthe\tO\napical\tO\ndomain\tO\nof\tO\nhepatocytes\tO\nbut\tO\nseems\tO\nalso\tO\nto\tO\nbe\tO\nexpressed\tO\nat\tO\nthe\tO\napical\tO\nmembrane\tO\nof\tO\nbrain\tO\ncapillary\tO\nendothelial\tO\ncells\tO\nthat\tO\nform\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n(\tO\nBBB\tO\n)\tO\n.\tO\n\nMRP2\tO\nis\tO\nabsent\tO\nin\tO\nthe\tO\ntransport\tO\n-\tO\ndeficient\tO\n(\tO\nTR\tO\n(\tO\n-\tO\n)\tO\n)\tO\nWistar\tO\nrat\tO\nmutant\tO\n,\tO\nso\tO\nthat\tO\nthis\tO\nrat\tO\nstrain\tO\nwas\tO\nvery\tO\nhelpful\tO\nin\tO\ndefining\tO\nsubstrates\tO\nof\tO\nMRP2\tO\nby\tO\ncomparing\tO\ntissue\tO\nconcentrations\tO\nor\tO\nfunctional\tO\nactivities\tO\nof\tO\ncompounds\tO\nin\tO\nMRP2\tO\n-\tO\ndeficient\tO\nrats\tO\nwith\tO\nthose\tO\nin\tO\ntransport\tO\n-\tO\ncompetent\tO\nWistar\tO\nrats\tO\n.\tO\n\nBy\tO\nusing\tO\nthis\tO\nstrategy\tO\nto\tO\nstudy\tO\nthe\tO\ninvolvement\tO\nof\tO\nMRP2\tO\nin\tO\nbrain\tO\naccess\tO\nof\tO\nantiepileptic\tO\ndrugs\tO\n(\tO\nAEDs\tO\n)\tO\n,\tO\nwe\tO\nrecently\tO\nreported\tO\nthat\tO\nphenytoin\tB-Chemical\nis\tO\na\tO\nsubstrate\tO\nfor\tO\nMRP2\tO\nin\tO\nthe\tO\nBBB\tO\n.\tO\n\nHowever\tO\n,\tO\none\tO\ndrawback\tO\nof\tO\nsuch\tO\nstudies\tO\nin\tO\ngenetically\tO\ndeficient\tO\nrats\tO\nis\tO\nthe\tO\nfact\tO\nthat\tO\ncompensatory\tO\nchanges\tO\nwith\tO\nupregulation\tO\nof\tO\nother\tO\ntransporters\tO\ncan\tO\noccur\tO\n.\tO\n\nThis\tO\nprompted\tO\nus\tO\nto\tO\nstudy\tO\nthe\tO\nbrain\tO\nexpression\tO\nof\tO\nP\tO\n-\tO\nglycoprotein\tO\n(\tO\nPgp\tO\n)\tO\n,\tO\na\tO\nmajor\tO\ndrug\tO\nefflux\tO\ntransporter\tO\nin\tO\nmany\tO\ntissues\tO\n,\tO\nincluding\tO\nthe\tO\nBBB\tO\n,\tO\nin\tO\nTR\tO\n(\tO\n-\tO\n)\tO\nrats\tO\ncompared\tO\nwith\tO\nnonmutant\tO\n(\tO\nwild\tO\n-\tO\ntype\tO\n)\tO\nWistar\tO\nrats\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nexpression\tO\nof\tO\nMRP2\tO\nand\tO\nPgp\tO\nin\tO\nbrain\tO\nand\tO\nliver\tO\nsections\tO\nof\tO\nTR\tO\n(\tO\n-\tO\n)\tO\nrats\tO\nand\tO\nnormal\tO\nWistar\tO\nrats\tO\nwas\tO\ndetermined\tO\nwith\tO\nimmunohistochemistry\tO\n,\tO\nby\tO\nusing\tO\na\tO\nnovel\tO\n,\tO\nhighly\tO\nselective\tO\nmonoclonal\tO\nMRP2\tO\nantibody\tO\nand\tO\nthe\tO\nmonoclonal\tO\nPgp\tO\nantibody\tO\nC219\tO\n,\tO\nrespectively\tO\n.\tO\n\nRESULTS\tO\n:\tO\nImmunofluorescence\tO\nstaining\tO\nwith\tO\nthe\tO\nMRP2\tO\nantibody\tO\nwas\tO\nfound\tO\nto\tO\nlabel\tO\na\tO\nhigh\tO\nnumber\tO\nof\tO\nmicrovessels\tO\nthroughout\tO\nthe\tO\nbrain\tO\nin\tO\nnormal\tO\nWistar\tO\nrats\tO\n,\tO\nwhereas\tO\nsuch\tO\nlabeling\tO\nwas\tO\nabsent\tO\nin\tO\nTR\tO\n(\tO\n-\tO\n)\tO\nrats\tO\n.\tO\n\nTR\tO\n(\tO\n-\tO\n)\tO\nrats\tO\nexhibited\tO\na\tO\nsignificant\tO\nup\tO\n-\tO\nregulation\tO\nof\tO\nPgp\tO\nin\tO\nbrain\tO\ncapillary\tO\nendothelial\tO\ncells\tO\ncompared\tO\nwith\tO\nwild\tO\n-\tO\ntype\tO\ncontrols\tO\n.\tO\n\nNo\tO\nsuch\tO\nobvious\tO\nupregulation\tO\nof\tO\nPgp\tO\nwas\tO\nobserved\tO\nin\tO\nliver\tO\nsections\tO\n.\tO\n\nA\tO\ncomparable\tO\noverexpression\tO\nof\tO\nPgp\tO\nin\tO\nthe\tO\nBBB\tO\nwas\tO\nobtained\tO\nafter\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nin\tO\nwild\tO\n-\tO\ntype\tO\nWistar\tO\nrats\tO\n.\tO\n\nExperiments\tO\nwith\tO\nsystemic\tO\nadministration\tO\nof\tO\nthe\tO\nPgp\tO\nsubstrate\tO\nphenobarbital\tB-Chemical\nand\tO\nthe\tO\nselective\tO\nPgp\tO\ninhibitor\tO\ntariquidar\tB-Chemical\nin\tO\nTR\tO\n(\tO\n-\tO\n)\tO\nrats\tO\nsubstantiated\tO\nthat\tO\nPgp\tO\nis\tO\nfunctional\tO\nand\tO\ncompensates\tO\nfor\tO\nthe\tO\nlack\tO\nof\tO\nMRP2\tO\nin\tO\nthe\tO\nBBB\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ndata\tO\non\tO\nTR\tO\n(\tO\n-\tO\n)\tO\nrats\tO\nindicate\tO\nthat\tO\nPgp\tO\nplays\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\ncompensation\tO\nof\tO\nMRP2\tO\ndeficiency\tO\nin\tO\nthe\tO\nBBB\tO\n.\tO\n\nBecause\tO\nsuch\tO\na\tO\ncompensatory\tO\nmechanism\tO\nmost\tO\nlikely\tO\noccurs\tO\nto\tO\nreduce\tO\ninjury\tB-Disease\nto\tI-Disease\nthe\tI-Disease\nbrain\tI-Disease\nfrom\tO\ncytotoxic\tO\ncompounds\tO\n,\tO\nthe\tO\npresent\tO\ndata\tO\nsubstantiate\tO\nthe\tO\nconcept\tO\nthat\tO\nMRP2\tO\nperforms\tO\na\tO\nprotective\tO\nrole\tO\nin\tO\nthe\tO\nBBB\tO\n.\tO\n\nFurthermore\tO\n,\tO\nour\tO\ndata\tO\nsuggest\tO\nthat\tO\nTR\tO\n(\tO\n-\tO\n)\tO\nrats\tO\nare\tO\nan\tO\ninteresting\tO\ntool\tO\nto\tO\nstudy\tO\nconsequences\tO\nof\tO\noverexpression\tO\nof\tO\nPgp\tO\nin\tO\nthe\tO\nBBB\tO\non\tO\naccess\tO\nof\tO\ndrugs\tO\nin\tO\nthe\tO\nbrain\tO\n,\tO\nwithout\tO\nthe\tO\nneed\tO\nof\tO\ninducing\tO\nseizures\tB-Disease\nor\tO\nother\tO\nPgp\tO\n-\tO\nenhancing\tO\nevents\tO\nfor\tO\nthis\tO\npurpose\tO\n.\tO\n\nRole\tO\nof\tO\nxanthine\tB-Chemical\noxidase\tO\nin\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nrats\tO\n.\tO\n\n1\tO\n.\tO\n\nGlucocorticoid\tO\n-\tO\ninduced\tO\nhypertension\tB-Disease\n(\tO\nGC\tO\n-\tO\nHT\tB-Disease\n)\tO\nin\tO\nthe\tO\nrat\tO\nis\tO\nassociated\tO\nwith\tO\nnitric\tB-Chemical\noxide\tI-Chemical\n-\tO\nredox\tO\nimbalance\tO\n.\tO\n\n2\tO\n.\tO\n\nWe\tO\nstudied\tO\nthe\tO\nrole\tO\nof\tO\nxanthine\tB-Chemical\noxidase\tO\n(\tO\nXO\tO\n)\tO\n,\tO\nwhich\tO\nis\tO\nimplicated\tO\nin\tO\nthe\tO\nproduction\tO\nof\tO\nreactive\tO\noxygen\tO\nspecies\tO\n,\tO\nin\tO\ndexamethasone\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n(\tO\ndex\tB-Chemical\n-\tO\nHT\tB-Disease\n)\tO\n.\tO\n\n3\tO\n.\tO\n\nThirty\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\ndivided\tO\nrandomly\tO\ninto\tO\nfour\tO\ntreatment\tO\ngroups\tO\n:\tO\nsaline\tO\n,\tO\ndexamethasone\tB-Chemical\n(\tO\ndex\tB-Chemical\n)\tO\n,\tO\nallopurinol\tB-Chemical\nplus\tO\nsaline\tO\n,\tO\nand\tO\nallopurinol\tB-Chemical\nplus\tO\ndex\tB-Chemical\n.\tO\n\n4\tO\n.\tO\n\nSystolic\tO\nblood\tO\npressures\tO\n(\tO\nSBP\tO\n)\tO\nand\tO\nbodyweights\tO\nwere\tO\nrecorded\tO\neach\tO\nalternate\tO\nday\tO\n.\tO\n\nThymus\tO\nweight\tO\nwas\tO\nused\tO\nas\tO\na\tO\nmarker\tO\nof\tO\nglucocorticoid\tO\nactivity\tO\n,\tO\nand\tO\nserum\tO\nurate\tB-Chemical\nto\tO\nassess\tO\nXO\tO\ninhibition\tO\n.\tO\n\n5\tO\n.\tO\n\nDex\tB-Chemical\nincreased\tB-Disease\nSBP\tI-Disease\n(\tO\n110\tO\n+\tO\n/\tO\n-\tO\n2\tO\n-\tO\n126\tO\n+\tO\n/\tO\n-\tO\n3\tO\nmmHg\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\ndecreased\tB-Disease\nthymus\tI-Disease\n(\tI-Disease\nP\tI-Disease\n<\tI-Disease\n0\tI-Disease\n.\tI-Disease\n001\tI-Disease\n)\tI-Disease\nand\tI-Disease\nbodyweights\tI-Disease\n(\tO\nP\tO\n\"\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nAllopurinol\tB-Chemical\ndecreased\tO\nserum\tO\nurate\tB-Chemical\nfrom\tO\n76\tO\n+\tO\n/\tO\n-\tO\n5\tO\nto\tO\n30\tO\n+\tO\n/\tO\n-\tO\n3\tO\nmicromol\tO\n/\tO\nL\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nin\tO\nsaline\tO\nand\tO\nfrom\tO\n84\tO\n+\tO\n/\tO\n-\tO\n13\tO\nto\tO\n28\tO\n+\tO\n/\tO\n-\tO\n2\tO\nmicromol\tO\n/\tO\nL\tO\nin\tO\ndex\tB-Chemical\n-\tO\ntreated\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\ngroups\tO\n.\tO\n\n6\tO\n.\tO\n\nAllopurinol\tB-Chemical\ndid\tO\nnot\tO\nprevent\tO\ndex\tB-Chemical\n-\tO\nHT\tB-Disease\n.\tO\n\nThis\tO\n,\tO\ntogether\tO\nwith\tO\nour\tO\nprevious\tO\nfindings\tO\nthat\tO\nallopurinol\tB-Chemical\nfailed\tO\nto\tO\nprevent\tO\nadrenocorticotrophic\tO\nhormone\tO\ninduced\tO\nhypertension\tB-Disease\n,\tO\nsuggests\tO\nthat\tO\nXO\tO\nactivity\tO\nis\tO\nnot\tO\na\tO\nmajor\tO\ndeterminant\tO\nof\tO\nGC\tO\n-\tO\nHT\tB-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nSide\tO\neffects\tO\nof\tO\npostoperative\tO\nadministration\tO\nof\tO\nmethylprednisolone\tB-Chemical\nand\tO\ngentamicin\tB-Chemical\ninto\tO\nthe\tO\nposterior\tO\nsub\tO\n-\tO\nTenon\tO\n'\tO\ns\tO\nspace\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nassess\tO\nthe\tO\nincidence\tO\nof\tO\npostoperative\tO\nemetic\tO\nside\tO\neffects\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\nmethylprednisolone\tB-Chemical\nand\tO\ngentamicin\tB-Chemical\ninto\tO\nthe\tO\nposterior\tO\nsub\tO\n-\tO\nTenon\tO\n'\tO\ns\tO\nspace\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nroutine\tO\ncataract\tB-Disease\nsurgery\tO\n.\tO\n\nSETTING\tO\n:\tO\nSt\tO\n.\tO\n\nLuke\tO\n'\tO\ns\tO\nHospital\tO\n,\tO\nGwardamangia\tO\n,\tO\nMalta\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\ndouble\tO\n-\tO\nblind\tO\ndouble\tO\n-\tO\narmed\tO\nprospective\tO\nstudy\tO\ncomprised\tO\n40\tO\npatients\tO\nwho\tO\nhad\tO\nuneventful\tO\nsutureless\tO\nphacoemulsification\tO\nunder\tO\nsub\tO\n-\tO\nTenon\tO\n'\tO\ns\tO\nlocal\tO\ninfiltration\tO\nof\tO\n3\tO\nmL\tO\nof\tO\nplain\tO\nlignocaine\tB-Chemical\n.\tO\n\nAt\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nprocedure\tO\n,\tO\nGroup\tO\nA\tO\n(\tO\nn\tO\n=\tO\n20\tO\n)\tO\nhad\tO\n20\tO\nmg\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmL\tO\nof\tO\nmethylprednisolone\tB-Chemical\nand\tO\n10\tO\nmg\tO\n/\tO\n0\tO\n.\tO\n5\tO\nmL\tO\nof\tO\ngentamicin\tB-Chemical\ninjected\tO\ninto\tO\nthe\tO\nposterior\tO\nsub\tO\n-\tO\nTenon\tO\n'\tO\ns\tO\nspace\tO\nand\tO\nGroup\tO\nB\tO\n(\tO\nn\tO\n=\tO\n20\tO\n)\tO\nhad\tO\nthe\tO\nsame\tO\ncombination\tO\ninjected\tO\ninto\tO\nthe\tO\nanterior\tO\nsub\tO\n-\tO\nTenon\tO\n'\tO\ns\tO\nspace\tO\n.\tO\n\nPostoperatively\tO\n,\tO\nall\tO\npatients\tO\nwere\tO\nassessed\tO\nfor\tO\nsymptoms\tO\nof\tO\nnausea\tB-Disease\n,\tI-Disease\nvomiting\tI-Disease\n,\tO\nand\tO\nheadache\tB-Disease\n.\tO\n\nA\tO\nchi\tO\n-\tO\nsquare\tO\ntest\tO\nwas\tO\nused\tO\nto\tO\nassess\tO\nthe\tO\nstatistical\tO\nsignificance\tO\nof\tO\nresults\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSixty\tO\npercent\tO\nin\tO\nGroup\tO\nA\tO\ndeveloped\tO\npostoperative\tB-Disease\nemetic\tI-Disease\nsymptoms\tI-Disease\n,\tO\nheadache\tB-Disease\n,\tO\nor\tO\nboth\tO\n;\tO\n1\tO\npatient\tO\nin\tO\nGroup\tO\nB\tO\ndeveloped\tO\nsymptoms\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nadministration\tO\nof\tO\nmethylprednisolone\tB-Chemical\nand\tO\ngentamicin\tB-Chemical\nin\tO\nthe\tO\nposterior\tO\nsub\tO\n-\tO\nTenon\tO\n'\tO\ns\tO\nspace\tO\nwas\tO\nrelated\tO\nto\tO\na\tO\nhigh\tO\nincidence\tO\nof\tO\nside\tO\neffects\tO\nincluding\tO\nnausea\tB-Disease\n,\tI-Disease\nvomiting\tI-Disease\n,\tO\nand\tO\nheadache\tB-Disease\n.\tO\n\nAll\tO\nadverse\tO\neffects\tO\nwere\tO\nself\tO\n-\tO\nlimiting\tO\n.\tO\n\nAssessment\tO\nof\tO\na\tO\nnew\tO\nnon\tO\n-\tO\ninvasive\tO\nindex\tO\nof\tO\ncardiac\tO\nperformance\tO\nfor\tO\ndetection\tO\nof\tO\ndobutamine\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nElectrocardiography\tO\nhas\tO\na\tO\nvery\tO\nlow\tO\nsensitivity\tO\nin\tO\ndetecting\tO\ndobutamine\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nassess\tO\nthe\tO\nadded\tO\ndiagnostic\tO\nvalue\tO\nof\tO\na\tO\nnew\tO\ncardiac\tO\nperformance\tO\nindex\tO\n(\tO\ndP\tO\n/\tO\ndtejc\tO\n)\tO\nmeasurement\tO\n,\tO\nbased\tO\non\tO\nbrachial\tO\nartery\tO\nflow\tO\nchanges\tO\n,\tO\nas\tO\ncompared\tO\nto\tO\nstandard\tO\n12\tO\n-\tO\nlead\tO\nECG\tO\n,\tO\nfor\tO\ndetecting\tO\ndobutamine\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n,\tO\nusing\tO\nTc99m\tB-Chemical\n-\tI-Chemical\nSestamibi\tI-Chemical\nsingle\tO\n-\tO\nphoton\tO\nemission\tO\ncomputed\tO\ntomography\tO\nas\tO\nthe\tO\ngold\tO\nstandard\tO\nof\tO\ncomparison\tO\nto\tO\nassess\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nischemia\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nstudy\tO\ngroup\tO\ncomprised\tO\n40\tO\npatients\tO\nundergoing\tO\nSestamibi\tB-Chemical\n-\tO\nSPECT\tO\n/\tO\ndobutamine\tB-Chemical\nstress\tO\ntest\tO\n.\tO\n\nSimultaneous\tO\nmeasurements\tO\nof\tO\nECG\tO\nand\tO\nbrachial\tO\nartery\tO\ndP\tO\n/\tO\ndtejc\tO\nwere\tO\nperformed\tO\nat\tO\neach\tO\ndobutamine\tB-Chemical\nlevel\tO\n.\tO\n\nIn\tO\n19\tO\nof\tO\nthe\tO\n40\tO\npatients\tO\nperfusion\tO\ndefects\tO\ncompatible\tO\nwith\tO\nischemia\tB-Disease\nwere\tO\ndetected\tO\non\tO\nSPECT\tO\n.\tO\n\nThe\tO\nincrease\tO\nin\tO\ndP\tO\n/\tO\ndtejc\tO\nduring\tO\ninfusion\tO\nof\tO\ndobutamine\tB-Chemical\nin\tO\nthis\tO\ngroup\tO\nwas\tO\nseverely\tO\nimpaired\tO\nas\tO\ncompared\tO\nto\tO\nthe\tO\nnon\tO\n-\tO\nischemic\tO\ngroup\tO\n.\tO\n\ndP\tO\n/\tO\ndtejc\tO\noutcome\tO\nwas\tO\ncombined\tO\nwith\tO\nthe\tO\nECG\tO\nresults\tO\n,\tO\ngiving\tO\nan\tO\nECG\tO\n-\tO\nenhanced\tO\nvalue\tO\n,\tO\nand\tO\ncompared\tO\nto\tO\nECG\tO\nalone\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nsensitivity\tO\nimproved\tO\ndramatically\tO\nfrom\tO\n16\tO\n%\tO\nto\tO\n79\tO\n%\tO\n,\tO\npositive\tO\npredictive\tO\nvalue\tO\nincreased\tO\nfrom\tO\n60\tO\n%\tO\nto\tO\n68\tO\n%\tO\nand\tO\nnegative\tO\npredictive\tO\nvalue\tO\nfrom\tO\n54\tO\n%\tO\nto\tO\n78\tO\n%\tO\n,\tO\nand\tO\nspecificity\tO\ndecreased\tO\nfrom\tO\n90\tO\n%\tO\nto\tO\n67\tO\n%\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIf\tO\nECG\tO\nalone\tO\nis\tO\nused\tO\nfor\tO\nspecificity\tO\n,\tO\nthe\tO\ncombination\tO\nwith\tO\ndP\tO\n/\tO\ndtejc\tO\nimproved\tO\nthe\tO\nsensitivity\tO\nof\tO\nthe\tO\ntest\tO\nand\tO\ncould\tO\nbe\tO\na\tO\ncost\tO\n-\tO\nsavings\tO\nalternative\tO\nto\tO\ncardiac\tO\nimaging\tO\nor\tO\nperfusion\tO\nstudies\tO\nto\tO\ndetect\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n,\tO\nespecially\tO\nin\tO\npatients\tO\nunable\tO\nto\tO\nexercise\tO\n.\tO\n\nCocaine\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n:\tO\nclinical\tO\nobservations\tO\nand\tO\npathogenetic\tO\nconsiderations\tO\n.\tO\n\nClinical\tO\nand\tO\nexperimental\tO\ndata\tO\npublished\tO\nto\tO\ndate\tO\nsuggest\tO\nseveral\tO\npossible\tO\nmechanisms\tO\nby\tO\nwhich\tO\ncocaine\tB-Chemical\nmay\tO\nresult\tO\nin\tO\nacute\tB-Disease\nmyocardial\tI-Disease\ninfarction\tI-Disease\n.\tO\n\nIn\tO\nindividuals\tO\nwith\tO\npreexisting\tO\n,\tO\nhigh\tO\n-\tO\ngrade\tO\ncoronary\tO\narterial\tO\nnarrowing\tO\n,\tO\nacute\tB-Disease\nmyocardial\tI-Disease\ninfarction\tI-Disease\nmay\tO\nresult\tO\nfrom\tO\nan\tO\nincrease\tO\nin\tO\nmyocardial\tO\noxygen\tB-Chemical\ndemand\tO\nassociated\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nincrease\tO\nin\tO\nrate\tO\n-\tO\npressure\tO\nproduct\tO\n.\tO\n\nIn\tO\nother\tO\nindividuals\tO\nwith\tO\nno\tO\nunderlying\tO\natherosclerotic\tB-Disease\nobstruction\tI-Disease\n,\tO\ncoronary\tB-Disease\nocclusion\tI-Disease\nmay\tO\nbe\tO\ndue\tO\nto\tO\nspasm\tB-Disease\n,\tO\nthrombus\tB-Disease\n,\tO\nor\tO\nboth\tO\n.\tO\n\nWith\tO\nregard\tO\nto\tO\nspasm\tB-Disease\n,\tO\nthe\tO\nclinical\tO\nfindings\tO\nare\tO\nlargely\tO\ncircumstantial\tO\n,\tO\nand\tO\nthe\tO\nlocus\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nvasoconstriction\tO\nremains\tO\nspeculative\tO\n.\tO\n\nAlthough\tO\ncertain\tO\nclinical\tO\nand\tO\nexperimental\tO\nfindings\tO\nsupport\tO\nthe\tO\nhypothesis\tO\nthat\tO\nspasm\tB-Disease\ninvolves\tO\nthe\tO\nepicardial\tO\n,\tO\nmedium\tO\n-\tO\nsize\tO\nvessels\tO\n,\tO\nother\tO\ndata\tO\nsuggest\tO\nintramural\tO\nvasoconstriction\tO\n.\tO\n\nDiffuse\tO\nintramural\tO\nvasoconstriction\tO\nis\tO\nnot\tO\nconsistent\tO\nwith\tO\nreports\tO\nof\tO\nsegmental\tO\n,\tO\ndiscrete\tO\ninfarction\tB-Disease\n.\tO\n\nWhereas\tO\ncertain\tO\nin\tO\nvivo\tO\ndata\tO\nsuggest\tO\nthat\tO\nthese\tO\neffects\tO\nare\tO\nalpha\tO\n-\tO\nmediated\tO\n,\tO\nother\tO\nin\tO\nvitro\tO\ndata\tO\nsuggest\tO\nthe\tO\nopposite\tO\n.\tO\n\nThe\tO\nfinding\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nvasoconstriction\tO\nin\tO\nsegments\tO\nof\tO\n(\tO\nnoninnervated\tO\n)\tO\nhuman\tO\numbilical\tO\nartery\tO\nsuggests\tO\nthat\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nintact\tO\ninnervation\tO\nis\tO\nnot\tO\nsufficient\tO\nto\tO\nexplain\tO\nthe\tO\ndiscrepant\tO\ndata\tO\ninvolving\tO\nthe\tO\npossibility\tO\nof\tO\nalpha\tO\n-\tO\nmediated\tO\neffects\tO\n.\tO\n\nFinally\tO\n,\tO\nthe\tO\ncontribution\tO\nof\tO\na\tO\nprimary\tO\n,\tO\nthrombotic\tB-Disease\neffect\tO\nof\tO\ncocaine\tB-Chemical\nhas\tO\nnot\tO\nbeen\tO\nexcluded\tO\n.\tO\n\nProteomic\tO\nanalysis\tO\nof\tO\nstriatal\tO\nproteins\tO\nin\tO\nthe\tO\nrat\tO\nmodel\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\n(\tO\nLID\tB-Disease\n)\tO\nis\tO\namong\tO\nthe\tO\nmotor\tO\ncomplications\tO\nthat\tO\narise\tO\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\npatients\tO\nafter\tO\na\tO\nprolonged\tO\ntreatment\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\n.\tO\n\nTo\tO\nthis\tO\nday\tO\n,\tO\ntranscriptome\tO\nanalysis\tO\nhas\tO\nbeen\tO\nperformed\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nLID\tB-Disease\n[\tO\nNeurobiol\tO\n.\tO\nDis\tO\n.\tO\n,\tO\n17\tO\n(\tO\n2004\tO\n)\tO\n,\tO\n219\tO\n]\tO\nbut\tO\ninformation\tO\nregarding\tO\nthe\tO\nproteome\tO\nis\tO\nstill\tO\nlacking\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\nchanges\tO\noccurring\tO\nat\tO\nthe\tO\nprotein\tO\nlevel\tO\nin\tO\nstriatal\tO\nsamples\tO\nobtained\tO\nfrom\tO\nthe\tO\nunilaterally\tO\n6\tB-Chemical\n-\tI-Chemical\nhydroxydopamine\tI-Chemical\n-\tO\nlesion\tO\nrat\tO\nmodel\tO\nof\tO\nPD\tB-Disease\ntreated\tO\nwith\tO\nsaline\tO\n,\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\nor\tO\nbromocriptine\tB-Chemical\nusing\tO\ntwo\tO\n-\tO\ndimensional\tO\ndifference\tO\ngel\tO\nelectrophoresis\tO\nand\tO\nmass\tO\nspectrometry\tO\n(\tO\nMS\tO\n)\tO\n.\tO\n\nRats\tO\ntreated\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\nDOPA\tI-Chemical\nwere\tO\nallocated\tO\nto\tO\ntwo\tO\ngroups\tO\nbased\tO\non\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nLID\tB-Disease\n.\tO\n\nAmong\tO\nthe\tO\n2000\tO\nspots\tO\ncompared\tO\nfor\tO\nstatistical\tO\ndifference\tO\n,\tO\n67\tO\nspots\tO\nwere\tO\nsignificantly\tO\nchanged\tO\nin\tO\nabundance\tO\nand\tO\nidentified\tO\nusing\tO\nmatrix\tO\n-\tO\nassisted\tO\nlaser\tO\ndesorption\tO\n/\tO\nionization\tO\ntime\tO\n-\tO\nof\tO\n-\tO\nflight\tO\nMS\tO\n,\tO\natmospheric\tO\npressure\tO\nmatrix\tO\n-\tO\nassisted\tO\nlaser\tO\ndesorption\tO\n/\tO\nionization\tO\nand\tO\nHPLC\tO\ncoupled\tO\ntandem\tO\nMS\tO\n(\tO\nLC\tO\n/\tO\nMS\tO\n/\tO\nMS\tO\n)\tO\n.\tO\n\nOut\tO\nof\tO\nthese\tO\n67\tO\nproteins\tO\n,\tO\nLID\tB-Disease\nsignificantly\tO\nchanged\tO\nthe\tO\nexpression\tO\nlevel\tO\nof\tO\nfive\tO\nproteins\tO\n:\tO\nalphabeta\tO\n-\tO\ncrystalin\tO\n,\tO\ngamma\tO\n-\tO\nenolase\tO\n,\tO\nguanidoacetate\tO\nmethyltransferase\tO\n,\tO\nvinculin\tO\n,\tO\nand\tO\nproteasome\tO\nalpha\tO\n-\tO\n2\tO\nsubunit\tO\n.\tO\n\nComplementary\tO\ntechniques\tO\nsuch\tO\nas\tO\nwestern\tO\nimmunoblotting\tO\nand\tO\nimmunohistochemistry\tO\nwere\tO\nperformed\tO\nto\tO\ninvestigate\tO\nthe\tO\nvalidity\tO\nof\tO\nthe\tO\ndata\tO\nobtained\tO\nusing\tO\nthe\tO\nproteomic\tO\napproach\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthis\tO\nstudy\tO\nprovides\tO\nnew\tO\ninsights\tO\ninto\tO\nthe\tO\nprotein\tO\nchanges\tO\noccurring\tO\nin\tO\nLID\tB-Disease\n.\tO\n\nCardiac\tO\nAngiography\tO\nin\tO\nRenally\tO\nImpaired\tO\nPatients\tO\n(\tO\nCARE\tO\n)\tO\nstudy\tO\n:\tO\na\tO\nrandomized\tO\ndouble\tO\n-\tO\nblind\tO\ntrial\tO\nof\tO\ncontrast\tO\n-\tO\ninduced\tO\nnephropathy\tB-Disease\nin\tO\npatients\tO\nwith\tO\nchronic\tB-Disease\nkidney\tI-Disease\ndisease\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nNo\tO\ndirect\tO\ncomparisons\tO\nexist\tO\nof\tO\nthe\tO\nrenal\tO\ntolerability\tO\nof\tO\nthe\tO\nlow\tO\n-\tO\nosmolality\tO\ncontrast\tB-Chemical\nmedium\tI-Chemical\niopamidol\tB-Chemical\nwith\tO\nthat\tO\nof\tO\nthe\tO\niso\tO\n-\tO\nosmolality\tO\ncontrast\tB-Chemical\nmedium\tI-Chemical\niodixanol\tB-Chemical\nin\tO\nhigh\tO\n-\tO\nrisk\tO\npatients\tO\n.\tO\n\nMETHODS\tO\nAND\tO\nRESULTS\tO\n:\tO\nThe\tO\npresent\tO\nstudy\tO\nis\tO\na\tO\nmulticenter\tO\n,\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\ncomparison\tO\nof\tO\niopamidol\tB-Chemical\nand\tO\niodixanol\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nchronic\tB-Disease\nkidney\tI-Disease\ndisease\tI-Disease\n(\tO\nestimated\tO\nglomerular\tO\nfiltration\tO\nrate\tO\n,\tO\n20\tO\nto\tO\n59\tO\nmL\tO\n/\tO\nmin\tO\n)\tO\nwho\tO\nunderwent\tO\ncardiac\tO\nangiography\tO\nor\tO\npercutaneous\tO\ncoronary\tO\ninterventions\tO\n.\tO\n\nSerum\tO\ncreatinine\tB-Chemical\n(\tO\nSCr\tO\n)\tO\nlevels\tO\nand\tO\nestimated\tO\nglomerular\tO\nfiltration\tO\nrate\tO\nwere\tO\nassessed\tO\nat\tO\nbaseline\tO\nand\tO\n2\tO\nto\tO\n5\tO\ndays\tO\nafter\tO\nreceiving\tO\nmedications\tO\n.\tO\n\nThe\tO\nprimary\tO\noutcome\tO\nwas\tO\na\tO\npostdose\tO\nSCr\tO\nincrease\tO\n>\tO\nor\tO\n=\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndL\tO\n(\tO\n44\tO\n.\tO\n2\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nover\tO\nbaseline\tO\n.\tO\n\nSecondary\tO\noutcomes\tO\nwere\tO\na\tO\npostdose\tO\nSCr\tO\nincrease\tO\n>\tO\nor\tO\n=\tO\n25\tO\n%\tO\n,\tO\na\tO\npostdose\tO\nestimated\tO\nglomerular\tO\nfiltration\tO\nrate\tO\ndecrease\tO\nof\tO\n>\tO\nor\tO\n=\tO\n25\tO\n%\tO\n,\tO\nand\tO\nthe\tO\nmean\tO\npeak\tO\nchange\tO\nin\tO\nSCr\tO\n.\tO\n\nIn\tO\n414\tO\npatients\tO\n,\tO\ncontrast\tO\nvolume\tO\n,\tO\npresence\tO\nof\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\n,\tO\nuse\tO\nof\tO\nN\tB-Chemical\n-\tI-Chemical\nacetylcysteine\tI-Chemical\n,\tO\nmean\tO\nbaseline\tO\nSCr\tO\n,\tO\nand\tO\nestimated\tO\nglomerular\tO\nfiltration\tO\nrate\tO\nwere\tO\ncomparable\tO\nin\tO\nthe\tO\n2\tO\ngroups\tO\n.\tO\n\nSCr\tO\nincreases\tO\n>\tO\nor\tO\n=\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndL\tO\noccurred\tO\nin\tO\n4\tO\n.\tO\n4\tO\n%\tO\n(\tO\n9\tO\nof\tO\n204\tO\npatients\tO\n)\tO\nafter\tO\niopamidol\tB-Chemical\nand\tO\n6\tO\n.\tO\n7\tO\n%\tO\n(\tO\n14\tO\nof\tO\n210\tO\npatients\tO\n)\tO\nafter\tO\niodixanol\tB-Chemical\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n39\tO\n)\tO\n,\tO\nwhereas\tO\nrates\tO\nof\tO\nSCr\tO\nincreases\tO\n>\tO\nor\tO\n=\tO\n25\tO\n%\tO\nwere\tO\n9\tO\n.\tO\n8\tO\n%\tO\nand\tO\n12\tO\n.\tO\n4\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n44\tO\n)\tO\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\ndiabetes\tB-Disease\n,\tO\nSCr\tO\nincreases\tO\n>\tO\nor\tO\n=\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndL\tO\nwere\tO\n5\tO\n.\tO\n1\tO\n%\tO\n(\tO\n4\tO\nof\tO\n78\tO\npatients\tO\n)\tO\nwith\tO\niopamidol\tB-Chemical\nand\tO\n13\tO\n.\tO\n0\tO\n%\tO\n(\tO\n12\tO\nof\tO\n92\tO\npatients\tO\n)\tO\nwith\tO\niodixanol\tB-Chemical\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n11\tO\n)\tO\n,\tO\nwhereas\tO\nSCr\tO\nincreases\tO\n>\tO\nor\tO\n=\tO\n25\tO\n%\tO\nwere\tO\n10\tO\n.\tO\n3\tO\n%\tO\nand\tO\n15\tO\n.\tO\n2\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n37\tO\n)\tO\n.\tO\n\nMean\tO\npost\tO\n-\tO\nSCr\tO\nincreases\tO\nwere\tO\nsignificantly\tO\nless\tO\nwith\tO\niopamidol\tB-Chemical\n(\tO\nall\tO\npatients\tO\n:\tO\n0\tO\n.\tO\n07\tO\nversus\tO\n0\tO\n.\tO\n12\tO\nmg\tO\n/\tO\ndL\tO\n,\tO\n6\tO\n.\tO\n2\tO\nversus\tO\n10\tO\n.\tO\n6\tO\nmicromol\tO\n/\tO\nL\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n03\tO\n;\tO\npatients\tO\nwith\tO\ndiabetes\tB-Disease\n:\tO\n0\tO\n.\tO\n07\tO\nversus\tO\n0\tO\n.\tO\n16\tO\nmg\tO\n/\tO\ndL\tO\n,\tO\n6\tO\n.\tO\n2\tO\nversus\tO\n14\tO\n.\tO\n1\tO\nmicromol\tO\n/\tO\nL\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nrate\tO\nof\tO\ncontrast\tO\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n,\tO\ndefined\tO\nby\tO\nmultiple\tO\nend\tO\npoints\tO\n,\tO\nis\tO\nnot\tO\nstatistically\tO\ndifferent\tO\nafter\tO\nthe\tO\nintraarterial\tO\nadministration\tO\nof\tO\niopamidol\tB-Chemical\nor\tO\niodixanol\tB-Chemical\nto\tO\nhigh\tO\n-\tO\nrisk\tO\npatients\tO\n,\tO\nwith\tO\nor\tO\nwithout\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\n.\tO\n\nAny\tO\ntrue\tO\ndifference\tO\nbetween\tO\nthe\tO\nagents\tO\nis\tO\nsmall\tO\nand\tO\nnot\tO\nlikely\tO\nto\tO\nbe\tO\nclinically\tO\nsignificant\tO\n.\tO\n\nA\tO\nnovel\tO\ncompound\tO\n,\tO\nmaltolyl\tB-Chemical\np\tI-Chemical\n-\tI-Chemical\ncoumarate\tI-Chemical\n,\tO\nattenuates\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\nand\tO\nshows\tO\nneuroprotective\tO\neffects\tO\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\ndementia\tB-Disease\nmodels\tO\n.\tO\n\nTo\tO\ndevelop\tO\na\tO\nnovel\tO\nand\tO\neffective\tO\ndrug\tO\nthat\tO\ncould\tO\nenhance\tO\ncognitive\tO\nfunction\tO\nand\tO\nneuroprotection\tO\n,\tO\nwe\tO\nnewly\tO\nsynthesized\tO\nmaltolyl\tB-Chemical\np\tI-Chemical\n-\tI-Chemical\ncoumarate\tI-Chemical\nby\tO\nthe\tO\nesterification\tO\nof\tO\nmaltol\tB-Chemical\nand\tO\np\tB-Chemical\n-\tI-Chemical\ncoumaric\tI-Chemical\nacid\tI-Chemical\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nwhether\tO\nmaltolyl\tB-Chemical\np\tI-Chemical\n-\tI-Chemical\ncoumarate\tI-Chemical\ncould\tO\nimprove\tO\ncognitive\tB-Disease\ndecline\tI-Disease\nin\tO\nscopolamine\tB-Chemical\n-\tO\ninjected\tO\nrats\tO\nand\tO\nin\tO\namyloid\tB-Chemical\nbeta\tI-Chemical\npeptide\tI-Chemical\n(\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\n42\tI-Chemical\n)\tI-Chemical\n-\tO\ninfused\tO\nrats\tO\n.\tO\n\nMaltolyl\tB-Chemical\np\tI-Chemical\n-\tI-Chemical\ncoumarate\tI-Chemical\nwas\tO\nfound\tO\nto\tO\nattenuate\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\nin\tO\nboth\tO\nrat\tO\nmodels\tO\nusing\tO\npassive\tO\navoidance\tO\ntest\tO\nand\tO\nto\tO\nreduce\tO\napoptotic\tO\ncell\tO\ndeath\tO\nobserved\tO\nin\tO\nthe\tO\nhippocampus\tO\nof\tO\nthe\tO\namyloid\tB-Chemical\nbeta\tI-Chemical\npeptide\tI-Chemical\n(\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\n42\tI-Chemical\n)\tI-Chemical\n-\tO\ninfused\tO\nrats\tO\n.\tO\n\nWe\tO\nalso\tO\nexamined\tO\nthe\tO\nneuroprotective\tO\neffects\tO\nof\tO\nmaltolyl\tB-Chemical\np\tI-Chemical\n-\tI-Chemical\ncoumarate\tI-Chemical\nin\tO\nvitro\tO\nusing\tO\nSH\tO\n-\tO\nSY5Y\tO\ncells\tO\n.\tO\n\nCells\tO\nwere\tO\npretreated\tO\nwith\tO\nmaltolyl\tB-Chemical\np\tI-Chemical\n-\tI-Chemical\ncoumarate\tI-Chemical\n,\tO\nbefore\tO\nexposed\tO\nto\tO\namyloid\tB-Chemical\nbeta\tI-Chemical\npeptide\tI-Chemical\n(\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\n42\tI-Chemical\n)\tI-Chemical\n,\tO\nglutamate\tB-Chemical\nor\tO\nH2O2\tB-Chemical\n.\tO\n\nWe\tO\nfound\tO\nthat\tO\nmaltolyl\tB-Chemical\np\tI-Chemical\n-\tI-Chemical\ncoumarate\tI-Chemical\nsignificantly\tO\ndecreased\tO\napoptotic\tO\ncell\tO\ndeath\tO\nand\tO\nreduced\tO\nreactive\tO\noxygen\tO\nspecies\tO\n,\tO\ncytochrome\tO\nc\tO\nrelease\tO\n,\tO\nand\tO\ncaspase\tO\n3\tO\nactivation\tO\n.\tO\n\nTaking\tO\nthese\tO\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\nresults\tO\ntogether\tO\n,\tO\nour\tO\nstudy\tO\nsuggests\tO\nthat\tO\nmaltolyl\tB-Chemical\np\tI-Chemical\n-\tI-Chemical\ncoumarate\tI-Chemical\nis\tO\na\tO\npotentially\tO\neffective\tO\ncandidate\tO\nagainst\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nthat\tO\nis\tO\ncharacterized\tO\nby\tO\nwide\tO\nspread\tO\nneuronal\tB-Disease\ndeath\tI-Disease\nand\tO\nprogressive\tO\ndecline\tB-Disease\nof\tI-Disease\ncognitive\tI-Disease\nfunction\tI-Disease\n.\tO\n\nAttenuation\tO\nof\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\nnigrostriatal\tO\ndopaminergic\tO\nneurotoxicity\tB-Disease\nin\tO\nmice\tO\nby\tO\nlipopolysaccharide\tB-Chemical\npretreatment\tO\n.\tO\n\nImmunological\tO\nactivation\tO\nhas\tO\nbeen\tO\nproposed\tO\nto\tO\nplay\tO\na\tO\nrole\tO\nin\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\ndopaminergic\tB-Disease\nterminal\tI-Disease\ndamage\tI-Disease\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\nexamined\tO\nthe\tO\nroles\tO\nof\tO\nlipopolysaccharide\tB-Chemical\n,\tO\na\tO\npro\tO\n-\tO\ninflammatory\tO\nand\tO\ninflammatory\tO\nfactor\tO\n,\tO\ntreatment\tO\nin\tO\nmodulating\tO\nthe\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\nnigrostriatal\tO\ndopamine\tB-Chemical\nneurotoxicity\tB-Disease\n.\tO\n\nLipopolysaccharide\tB-Chemical\npretreatment\tO\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nbasal\tO\nbody\tO\ntemperature\tO\nor\tO\nmethamphetamine\tB-Chemical\n-\tO\nelicited\tO\nhyperthermia\tB-Disease\nthree\tO\ndays\tO\nlater\tO\n.\tO\n\nSuch\tO\nsystemic\tO\nlipopolysaccharide\tB-Chemical\ntreatment\tO\nmitigated\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\nstriatal\tO\ndopamine\tB-Chemical\nand\tO\n3\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndihydroxyphenylacetic\tI-Chemical\nacid\tI-Chemical\ndepletions\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nAs\tO\nthe\tO\nmost\tO\npotent\tO\ndose\tO\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nof\tO\nlipopolysaccharide\tB-Chemical\nwas\tO\nadministered\tO\ntwo\tO\nweeks\tO\n,\tO\none\tO\nday\tO\nbefore\tO\nor\tO\nafter\tO\nthe\tO\nmethamphetamine\tB-Chemical\ndosing\tO\nregimen\tO\n,\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\nstriatal\tO\ndopamine\tB-Chemical\nand\tO\n3\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndihydroxyphenylacetic\tI-Chemical\nacid\tI-Chemical\ndepletions\tO\nremained\tO\nunaltered\tO\n.\tO\n\nMoreover\tO\n,\tO\nsystemic\tO\nlipopolysaccharide\tB-Chemical\npretreatment\tO\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nattenuated\tO\nlocal\tO\nmethamphetamine\tB-Chemical\ninfusion\tO\n-\tO\nproduced\tO\ndopamine\tB-Chemical\nand\tO\n3\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndihydroxyphenylacetic\tI-Chemical\nacid\tI-Chemical\ndepletions\tO\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nindicating\tO\nthat\tO\nthe\tO\nprotective\tO\neffect\tO\nof\tO\nlipopolysaccharide\tB-Chemical\nis\tO\nless\tO\nlikely\tO\ndue\tO\nto\tO\ninterrupted\tO\nperipheral\tO\ndistribution\tO\nor\tO\nmetabolism\tO\nof\tO\nmethamphetamine\tB-Chemical\n.\tO\n\nWe\tO\nconcluded\tO\na\tO\ncritical\tO\ntime\tO\nwindow\tO\nfor\tO\nsystemic\tO\nlipopolysaccharide\tB-Chemical\npretreatment\tO\nin\tO\nexerting\tO\neffective\tO\nprotection\tO\nagainst\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\nnigrostriatal\tO\ndopamine\tB-Chemical\nneurotoxicity\tB-Disease\n.\tO\n\nAcute\tO\nmyocarditis\tB-Disease\nassociated\tO\nwith\tO\nclozapine\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nA\tO\ncase\tO\nof\tO\nacute\tO\nmyocarditis\tB-Disease\nassociated\tO\nwith\tO\nthe\tO\ncommencement\tO\nof\tO\nclozapine\tB-Chemical\nis\tO\ndescribed\tO\n,\tO\nhighlighting\tO\nthe\tO\nonset\tO\n,\tO\ncourse\tO\nand\tO\npossible\tO\ncontributing\tO\nfactors\tO\n.\tO\n\nThere\tO\nis\tO\nan\tO\nurgent\tO\nneed\tO\nto\tO\nraise\tO\nawareness\tO\nabout\tO\nthis\tO\npotentially\tO\nfatal\tO\ncomplication\tO\nof\tO\nclozapine\tB-Chemical\nuse\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\n20\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\nwith\tO\nschizophrenia\tB-Disease\ndeveloped\tO\na\tO\nsudden\tO\nonset\tO\nof\tO\nmyocarditis\tB-Disease\nafter\tO\ncommencement\tO\nof\tO\nclozapine\tB-Chemical\n.\tO\n\nThe\tO\npatient\tO\nrecovered\tO\nwith\tO\nintensive\tO\nmedical\tO\nsupport\tO\n.\tO\n\nThe\tO\nsymptoms\tO\noccurred\tO\naround\tO\n2\tO\nweeks\tO\nafter\tO\nstarting\tO\nclozapine\tB-Chemical\nin\tO\nan\tO\ninpatient\tO\nsetting\tO\n.\tO\n\nPossible\tO\ncontributing\tO\nfactors\tO\nmay\tO\nhave\tO\nbeen\tO\nconcomitant\tO\nantidepressant\tB-Chemical\nuse\tO\nand\tO\nunaccustomed\tO\nphysical\tO\nactivity\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nMyocarditis\tB-Disease\nis\tO\nan\tO\nincreasingly\tO\nrecognized\tO\ncomplication\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nclozapine\tB-Chemical\n.\tO\n\nIt\tO\ncan\tO\nbe\tO\nfatal\tO\nif\tO\nnot\tO\nrecognized\tO\nand\tO\ntreated\tO\nearly\tO\n.\tO\n\nConsidering\tO\nthat\tO\nclozapine\tB-Chemical\nremains\tO\nthe\tO\ngold\tO\nstandard\tO\nin\tO\ntreatment\tO\nof\tO\nresistant\tO\npsychosis\tB-Disease\n,\tO\nthere\tO\nis\tO\nan\tO\nurgent\tO\nneed\tO\nto\tO\nraise\tO\nawareness\tO\namong\tO\nmedical\tO\nand\tO\nparamedical\tO\nstaff\tO\ninvolved\tO\nin\tO\nthe\tO\ncare\tO\nof\tO\nthese\tO\npatients\tO\n.\tO\n\nThere\tO\nare\tO\nalso\tO\nimplications\tO\nfor\tO\nrecommendations\tO\nand\tO\nregulations\tO\nregarding\tO\nthe\tO\nuse\tO\nof\tO\nclozapine\tB-Chemical\n.\tO\n\nSevere\tO\nrhabdomyolysis\tB-Disease\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nsecondary\tO\nto\tO\nconcomitant\tO\nuse\tO\nof\tO\nsimvastatin\tB-Chemical\n,\tO\namiodarone\tB-Chemical\n,\tO\nand\tO\natazanavir\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\nsevere\tO\ninteraction\tO\nbetween\tO\nsimvastatin\tB-Chemical\n,\tO\namiodarone\tB-Chemical\n,\tO\nand\tO\natazanavir\tB-Chemical\nresulting\tO\nin\tO\nrhabdomyolysis\tB-Disease\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nA\tO\n72\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwhite\tO\nman\tO\nwith\tO\nunderlying\tO\nhuman\tB-Disease\nimmunodeficiency\tI-Disease\nvirus\tI-Disease\n,\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n,\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n,\tO\nand\tO\nhyperlipidemia\tB-Disease\npresented\tO\nwith\tO\ngeneralized\tO\npain\tB-Disease\n,\tO\nfatigue\tB-Disease\n,\tO\nand\tO\ndark\tO\norange\tO\nurine\tO\nfor\tO\n3\tO\ndays\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\ntaking\tO\n80\tO\nmg\tO\nsimvastatin\tB-Chemical\nat\tO\nbedtime\tO\n(\tO\ninitiated\tO\n27\tO\ndays\tO\nearlier\tO\n)\tO\n;\tO\namiodarone\tB-Chemical\nat\tO\na\tO\ndose\tO\nof\tO\n400\tO\nmg\tO\ndaily\tO\nfor\tO\n7\tO\ndays\tO\n,\tO\nthen\tO\n200\tO\nmg\tO\ndaily\tO\n(\tO\ninitiated\tO\n19\tO\ndays\tO\nearlier\tO\n)\tO\n;\tO\nand\tO\n400\tO\nmg\tO\natazanavir\tB-Chemical\ndaily\tO\n(\tO\ninitiated\tO\nat\tO\nleast\tO\n2\tO\nyears\tO\npreviously\tO\n)\tO\n.\tO\n\nLaboratory\tO\nevaluation\tO\nrevealed\tO\n66\tO\n,\tO\n680\tO\nU\tO\n/\tO\nL\tO\ncreatine\tB-Chemical\nkinase\tO\n,\tO\n93\tO\nmg\tO\n/\tO\ndL\tO\nblood\tB-Chemical\nurea\tI-Chemical\nnitrogen\tI-Chemical\n,\tO\n4\tO\n.\tO\n6\tO\nmg\tO\n/\tO\ndL\tO\ncreatinine\tB-Chemical\n,\tO\n1579\tO\nU\tO\n/\tO\nL\tO\naspartate\tB-Chemical\naminotransferase\tO\n,\tO\nand\tO\n738\tO\nU\tO\n/\tO\nL\tO\nalanine\tB-Chemical\naminotransferase\tO\n.\tO\n\nSimvastatin\tB-Chemical\n,\tO\namiodarone\tB-Chemical\n,\tO\nand\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nhuman\tB-Disease\nimmunodeficiency\tI-Disease\nvirus\tI-Disease\nmedications\tO\nwere\tO\nall\tO\ntemporarily\tO\ndiscontinued\tO\nand\tO\nthe\tO\npatient\tO\nwas\tO\ngiven\tO\nforced\tO\nalkaline\tO\ndiuresis\tO\nand\tO\nstarted\tO\non\tO\ndialysis\tO\n.\tO\n\nNine\tO\ndays\tO\nlater\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\ncreatine\tB-Chemical\nkinase\tO\nhad\tO\ndropped\tO\nto\tO\n1695\tO\nU\tO\n/\tO\nL\tO\nand\tO\ncreatinine\tB-Chemical\nwas\tO\n3\tO\n.\tO\n3\tO\nmg\tO\n/\tO\ndL\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\ndischarged\tO\nand\tO\ncontinued\tO\noutpatient\tO\ndialysis\tO\nfor\tO\n1\tO\nmonth\tO\nuntil\tO\nhis\tO\nrenal\tO\nfunction\tO\nrecovered\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nThe\tO\nrisk\tO\nof\tO\nrhabdomyolysis\tB-Disease\nis\tO\nincreased\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nconcomitant\tO\ndrugs\tO\nthat\tO\ninhibit\tO\nsimvastatin\tB-Chemical\nmetabolism\tO\n.\tO\n\nSimvastatin\tB-Chemical\nis\tO\nmetabolized\tO\nby\tO\nCYP3A4\tO\n.\tO\n\nAmiodarone\tB-Chemical\nand\tO\natazanavir\tB-Chemical\nare\tO\nrecognized\tO\nCYP3A4\tO\ninhibitors\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPharmacokinetic\tO\ndifferences\tO\nin\tO\nstatins\tB-Chemical\nare\tO\nan\tO\nimportant\tO\nconsideration\tO\nfor\tO\nassessing\tO\nthe\tO\nrisk\tO\nof\tO\npotential\tO\ndrug\tO\ninteractions\tO\n.\tO\n\nIn\tO\npatients\tO\nrequiring\tO\nthe\tO\nconcurrent\tO\nuse\tO\nof\tO\nstatins\tB-Chemical\nand\tO\nCYP3A4\tO\ninhibitors\tO\n,\tO\npravastatin\tB-Chemical\n,\tO\nfluvastatin\tB-Chemical\n,\tO\nand\tO\nrosuvastatin\tB-Chemical\ncarry\tO\nthe\tO\nlowest\tO\nrisk\tO\nof\tO\ndrug\tO\ninteractions\tO\n;\tO\natorvastatin\tB-Chemical\ncarries\tO\nmoderate\tO\nrisk\tO\n,\tO\nwhereas\tO\nsimvastatin\tB-Chemical\nand\tO\nlovastatin\tB-Chemical\nhave\tO\nthe\tO\nhighest\tO\nrisk\tO\nand\tO\nshould\tO\nbe\tO\navoided\tO\nin\tO\npatients\tO\ntaking\tO\nconcomitant\tO\nCYP3A4\tO\ninhibitors\tO\n.\tO\n\nInteraction\tO\nbetween\tO\nwarfarin\tB-Chemical\nand\tO\nlevofloxacin\tB-Chemical\n:\tO\ncase\tO\nseries\tO\n.\tO\n\nWarfarin\tB-Chemical\nis\tO\nthe\tO\nmost\tO\nwidely\tO\nused\tO\noral\tO\nanticoagulant\tO\nand\tO\nis\tO\nindicated\tO\nfor\tO\nmany\tO\nclinical\tO\nconditions\tO\n.\tO\n\nLevofloxacin\tB-Chemical\n,\tO\na\tO\nfluoroquinolone\tB-Chemical\n,\tO\nis\tO\none\tO\nof\tO\nthe\tO\nmost\tO\ncommonly\tO\nprescribed\tO\nantibiotics\tO\nin\tO\nclinical\tO\npractice\tO\nand\tO\nis\tO\neffective\tO\nagainst\tO\nGram\tO\n-\tO\npositive\tO\n,\tO\nGram\tO\n-\tO\nnegative\tO\n,\tO\nand\tO\natypical\tO\nbacteria\tO\n.\tO\n\nWhile\tO\nsmall\tO\nprospective\tO\nstudies\tO\nhave\tO\nnot\tO\nrevealed\tO\nany\tO\nsignificant\tO\ndrug\tO\n-\tO\ndrug\tO\ninteraction\tO\nbetween\tO\nwarfarin\tB-Chemical\nand\tO\nlevofloxacin\tB-Chemical\n,\tO\nseveral\tO\ncase\tO\nreports\tO\nhave\tO\nindicated\tO\nthat\tO\nlevofloxacin\tB-Chemical\nmay\tO\nsignificantly\tO\npotentiate\tO\nthe\tO\nanticoagulation\tO\neffect\tO\nof\tO\nwarfarin\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\n3\tO\ncases\tO\nof\tO\nserious\tO\nbleeding\tB-Disease\ncomplications\tO\nthat\tO\nappear\tO\nto\tO\nbe\tO\nthe\tO\nresult\tO\nof\tO\nthe\tO\ninteraction\tO\nbetween\tO\nwarfarin\tB-Chemical\nand\tO\nlevofloxacin\tB-Chemical\n.\tO\n\nPhysicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\npotential\tO\ninteraction\tO\nand\tO\nuse\tO\ncaution\tO\nwhen\tO\nprescribing\tO\nlevofloxacin\tB-Chemical\nto\tO\npatients\tO\ntaking\tO\nwarfarin\tB-Chemical\n.\tO\n\nMutations\tO\nassociated\tO\nwith\tO\nlamivudine\tB-Chemical\n-\tO\nresistance\tO\nin\tO\ntherapy\tO\n-\tO\nna\tB-Chemical\nve\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tI-Disease\n(\tI-Disease\nHBV\tI-Disease\n)\tI-Disease\ninfected\tI-Disease\npatients\tO\nwith\tO\nand\tO\nwithout\tO\nHIV\tB-Disease\nco\tI-Disease\n-\tI-Disease\ninfection\tI-Disease\n:\tO\nimplications\tO\nfor\tO\nantiretroviral\tO\ntherapy\tO\nin\tO\nHBV\tB-Disease\nand\tI-Disease\nHIV\tI-Disease\nco\tI-Disease\n-\tI-Disease\ninfected\tI-Disease\nSouth\tO\nAfrican\tO\npatients\tO\n.\tO\n\nThis\tO\nwas\tO\nan\tO\nexploratory\tO\nstudy\tO\nto\tO\ninvestigate\tO\nlamivudine\tB-Chemical\n-\tO\nresistant\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\n(\tO\nHBV\tO\n)\tO\nstrains\tO\nin\tO\nselected\tO\nlamivudine\tB-Chemical\n-\tO\nna\tB-Chemical\nve\tO\nHBV\tO\ncarriers\tO\nwith\tO\nand\tO\nwithout\tO\nhuman\tB-Disease\nimmunodeficiency\tI-Disease\nvirus\tI-Disease\n(\tI-Disease\nHIV\tI-Disease\n)\tI-Disease\nco\tI-Disease\n-\tI-Disease\ninfection\tI-Disease\nin\tO\nSouth\tO\nAfrican\tO\npatients\tO\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\nlamivudine\tB-Chemical\n-\tO\nna\tB-Chemical\nve\tO\nHBV\tB-Disease\ninfected\tI-Disease\npatients\tO\nwith\tO\nor\tO\nwithout\tO\nHIV\tB-Disease\nco\tI-Disease\n-\tI-Disease\ninfection\tI-Disease\nwere\tO\nstudied\tO\n:\tO\n15\tO\nchronic\tO\nHBV\tB-Disease\nmono\tI-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\nand\tO\n20\tO\nHBV\tB-Disease\n-\tI-Disease\nHIV\tI-Disease\nco\tI-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\n.\tO\n\nThe\tO\nlatter\tO\ngroup\tO\nwas\tO\nfurther\tO\nsub\tO\n-\tO\ndivided\tO\ninto\tO\n13\tO\noccult\tO\nHBV\tO\n(\tO\nHBsAg\tB-Chemical\n-\tO\nnegative\tO\n)\tO\nand\tO\n7\tO\novert\tO\nHBV\tO\n(\tO\nHBsAg\tB-Chemical\n-\tO\npositive\tO\n)\tO\npatients\tO\n.\tO\n\nHBsAg\tB-Chemical\n,\tO\nanti\tO\n-\tO\nHBs\tO\n,\tO\nanti\tO\n-\tO\nHBc\tO\n,\tO\nand\tO\nanti\tO\n-\tO\nHIV\tO\n1\tO\n/\tO\n2\tO\nwere\tO\ndetermined\tO\nas\tO\npart\tO\nof\tO\nroutine\tO\ndiagnosis\tO\nusing\tO\nAxsym\tO\nassays\tO\n(\tO\nAbbott\tO\nLaboratories\tO\n,\tO\nNorth\tO\nChicago\tO\n,\tO\nIL\tO\n)\tO\n.\tO\n\nSerum\tO\nsamples\tO\nwere\tO\nPCR\tO\namplified\tO\nwith\tO\nHBV\tO\nreverse\tO\ntranscriptase\tO\n(\tO\nRT\tO\n)\tO\nprimers\tO\n,\tO\nfollowed\tO\nby\tO\ndirect\tO\nsequencing\tO\nacross\tO\nthe\tO\ntyrosine\tB-Chemical\n-\tO\nmethionine\tB-Chemical\n-\tO\naspartate\tB-Chemical\n-\tO\naspartate\tB-Chemical\n(\tO\nYMDD\tO\n)\tO\nmotif\tO\nof\tO\nthe\tO\nmajor\tO\ncatalytic\tO\nregion\tO\nin\tO\nthe\tO\nC\tO\ndomain\tO\nof\tO\nthe\tO\nHBV\tO\nRT\tO\nenzyme\tO\n.\tO\n\nHBV\tO\nviral\tO\nload\tO\nwas\tO\nperformed\tO\nwith\tO\nAmplicor\tO\nHBV\tO\nMonitor\tO\ntest\tO\nv2\tO\n.\tO\n0\tO\n(\tO\nRoche\tO\nDiagnostics\tO\n,\tO\nPenzberg\tO\n,\tO\nGermany\tO\n)\tO\n.\tO\n\nHBV\tO\nlamivudine\tB-Chemical\n-\tO\nresistant\tO\nstrains\tO\nwere\tO\ndetected\tO\nin\tO\n3\tO\nof\tO\n15\tO\nmono\tO\n-\tO\ninfected\tO\nchronic\tO\nhepatitis\tB-Disease\nB\tI-Disease\npatients\tO\nand\tO\n10\tO\nof\tO\n20\tO\nHBV\tB-Disease\n-\tI-Disease\nHIV\tI-Disease\nco\tI-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\n.\tO\n\nTo\tO\nthe\tO\nbest\tO\nof\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nconstitutes\tO\nthe\tO\nfirst\tO\nreport\tO\nof\tO\nHBV\tO\nlamivudine\tB-Chemical\n-\tO\nresistant\tO\nstrains\tO\nin\tO\ntherapy\tO\n-\tO\nna\tB-Chemical\nve\tO\nHBV\tB-Disease\n-\tI-Disease\nHIV\tI-Disease\nco\tI-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\n.\tO\n\nThe\tO\nHBV\tO\nviral\tO\nloads\tO\nfor\tO\nmono\tO\n-\tO\ninfected\tO\nand\tO\nco\tO\n-\tO\ninfected\tO\npatients\tO\nranged\tO\nfrom\tO\n3\tO\n.\tO\n32\tO\nx\tO\n10\tO\n(\tO\n2\tO\n)\tO\nto\tO\n3\tO\n.\tO\n82\tO\nx\tO\n10\tO\n(\tO\n7\tO\n)\tO\nand\tO\n<\tO\n200\tO\nto\tO\n4\tO\n.\tO\n40\tO\nx\tO\n10\tO\n(\tO\n3\tO\n)\tO\ncopies\tO\n/\tO\nml\tO\n,\tO\nrespectively\tO\n.\tO\n\nIt\tO\nremains\tO\nto\tO\nbe\tO\nseen\tO\nwhether\tO\nsuch\tO\npre\tO\n-\tO\nexisting\tO\nantiviral\tO\nmutations\tO\ncould\tO\nresult\tO\nin\tO\nwidespread\tO\nemergence\tO\nof\tO\nHBV\tO\nresistant\tO\nstrains\tO\nwhen\tO\nlamivudine\tB-Chemical\n-\tO\ncontaining\tO\nhighly\tO\nactive\tO\nantiretroviral\tO\n(\tO\nARV\tO\n)\tO\ntreatment\tO\n(\tO\nHAART\tO\n)\tO\nregimens\tO\nbecome\tO\nwidely\tO\napplied\tO\nin\tO\nSouth\tO\nAfrica\tO\n,\tO\nas\tO\nthis\tO\nis\tO\nlikely\tO\nto\tO\nhave\tO\npotential\tO\nimplications\tO\nin\tO\nthe\tO\nmanagement\tO\nof\tO\nHBV\tB-Disease\n-\tI-Disease\nHIV\tI-Disease\nco\tI-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\n.\tO\n\nRabbit\tB-Disease\nsyndrome\tI-Disease\n,\tO\nantidepressant\tB-Chemical\nuse\tO\n,\tO\nand\tO\ncerebral\tO\nperfusion\tO\nSPECT\tO\nscan\tO\nfindings\tO\n.\tO\n\nThe\tO\nrabbit\tB-Disease\nsyndrome\tI-Disease\nis\tO\nan\tO\nextrapyramidal\tO\nside\tO\neffect\tO\nassociated\tO\nwith\tO\nchronic\tO\nneuroleptic\tO\ntherapy\tO\n.\tO\n\nIts\tO\noccurrence\tO\nin\tO\na\tO\npatient\tO\nbeing\tO\ntreated\tO\nwith\tO\nimipramine\tB-Chemical\nis\tO\ndescribed\tO\n,\tO\nrepresenting\tO\nthe\tO\nfirst\tO\nreported\tO\ncase\tO\nof\tO\nthis\tO\nsyndrome\tO\nin\tO\nconjunction\tO\nwith\tO\nantidepressants\tB-Chemical\n.\tO\n\nRepeated\tO\ncerebral\tO\nperfusion\tO\nSPECT\tO\nscans\tO\nrevealed\tO\ndecreased\tB-Disease\nbasal\tI-Disease\nganglia\tI-Disease\nperfusion\tI-Disease\nwhile\tO\nthe\tO\nmovement\tB-Disease\ndisorder\tI-Disease\nwas\tO\npresent\tO\n,\tO\nand\tO\na\tO\nreturn\tO\nto\tO\nnormal\tO\nperfusion\tO\nwhen\tO\nthe\tO\nrabbit\tB-Disease\nsyndrome\tI-Disease\nresolved\tO\n.\tO\n\nEstrogen\tO\nprevents\tO\ncholesteryl\tB-Chemical\nester\tI-Chemical\naccumulation\tO\nin\tO\nmacrophages\tO\ninduced\tO\nby\tO\nthe\tO\nHIV\tO\nprotease\tO\ninhibitor\tO\nritonavir\tB-Chemical\n.\tO\n\nIndividuals\tO\nwith\tO\nHIV\tO\ncan\tO\nnow\tO\nlive\tO\nlong\tO\nlives\tO\nwith\tO\ndrug\tO\ntherapy\tO\nthat\tO\noften\tO\nincludes\tO\nprotease\tO\ninhibitors\tO\nsuch\tO\nas\tO\nritonavir\tB-Chemical\n.\tO\n\nMany\tO\npatients\tO\n,\tO\nhowever\tO\n,\tO\ndevelop\tO\nnegative\tO\nlong\tO\n-\tO\nterm\tO\nside\tO\neffects\tO\nsuch\tO\nas\tO\npremature\tB-Disease\natherosclerosis\tI-Disease\n.\tO\n\nWe\tO\nhave\tO\npreviously\tO\ndemonstrated\tO\nthat\tO\nritonavir\tB-Chemical\ntreatment\tO\nincreases\tO\natherosclerotic\tB-Disease\nlesion\tI-Disease\nformation\tO\nin\tO\nmale\tO\nmice\tO\nto\tO\na\tO\ngreater\tO\nextent\tO\nthan\tO\nin\tO\nfemale\tO\nmice\tO\n.\tO\n\nFurthermore\tO\n,\tO\nperipheral\tO\nblood\tO\nmonocytes\tO\nisolated\tO\nfrom\tO\nritonavir\tB-Chemical\n-\tO\ntreated\tO\nfemales\tO\nhad\tO\nless\tO\ncholesteryl\tB-Chemical\nester\tI-Chemical\naccumulation\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nwe\tO\nhave\tO\ninvestigated\tO\nthe\tO\nmolecular\tO\nmechanisms\tO\nby\tO\nwhich\tO\nfemale\tO\nhormones\tO\ninfluence\tO\ncholesterol\tB-Chemical\nmetabolism\tO\nin\tO\nmacrophages\tO\nin\tO\nresponse\tO\nto\tO\nthe\tO\nHIV\tO\nprotease\tO\ninhibitor\tO\nritonavir\tB-Chemical\n.\tO\n\nWe\tO\nhave\tO\nutilized\tO\nthe\tO\nhuman\tO\nmonocyte\tO\ncell\tO\nline\tO\n,\tO\nTHP\tO\n-\tO\n1\tO\nas\tO\na\tO\nmodel\tO\nto\tO\naddress\tO\nthis\tO\nquestion\tO\n.\tO\n\nBriefly\tO\n,\tO\ncells\tO\nwere\tO\ndifferentiated\tO\nfor\tO\n72\tO\nh\tO\nwith\tO\n100\tO\nnM\tO\nPMA\tO\nto\tO\nobtain\tO\na\tO\nmacrophage\tO\n-\tO\nlike\tO\nphenotype\tO\nin\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\n1\tO\nnM\tO\n17beta\tB-Chemical\n-\tI-Chemical\nestradiol\tI-Chemical\n(\tO\nE2\tB-Chemical\n)\tO\n,\tO\n100\tO\nnM\tO\nprogesterone\tB-Chemical\nor\tO\nvehicle\tO\n(\tO\n0\tO\n.\tO\n01\tO\n%\tO\nethanol\tB-Chemical\n)\tO\n.\tO\n\nCells\tO\nwere\tO\nthen\tO\ntreated\tO\nwith\tO\n30\tO\nng\tO\n/\tO\nml\tO\nritonavir\tB-Chemical\nor\tO\nvehicle\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\naggregated\tO\nLDL\tO\nfor\tO\n24\tO\nh\tO\n.\tO\n\nCell\tO\nextracts\tO\nwere\tO\nharvested\tO\n,\tO\nand\tO\nlipid\tO\nor\tO\ntotal\tO\nRNA\tO\nwas\tO\nisolated\tO\n.\tO\n\nE2\tB-Chemical\ndecreased\tO\nthe\tO\naccumulation\tO\nof\tO\ncholesteryl\tB-Chemical\nesters\tI-Chemical\nin\tO\nmacrophages\tO\nfollowing\tO\nritonavir\tB-Chemical\ntreatment\tO\n.\tO\n\nRitonavir\tB-Chemical\nincreased\tO\nthe\tO\nexpression\tO\nof\tO\nthe\tO\nscavenger\tO\nreceptor\tO\n,\tO\nCD36\tO\nmRNA\tO\n,\tO\nresponsible\tO\nfor\tO\nthe\tO\nuptake\tO\nof\tO\nLDL\tO\n.\tO\n\nAdditionally\tO\n,\tO\nritonavir\tB-Chemical\ntreatment\tO\nselectively\tO\nincreased\tO\nthe\tO\nrelative\tO\nlevels\tO\nof\tO\nPPARgamma\tO\nmRNA\tO\n,\tO\na\tO\ntranscription\tO\nfactor\tO\nresponsible\tO\nfor\tO\nthe\tO\nregulation\tO\nof\tO\nCD36\tO\nmRNA\tO\nexpression\tO\n.\tO\n\nTreatment\tO\nwith\tO\nE2\tB-Chemical\n,\tO\nhowever\tO\n,\tO\nfailed\tO\nto\tO\nprevent\tO\nthese\tO\nincreases\tO\nat\tO\nthe\tO\nmRNA\tO\nlevel\tO\n.\tO\n\nE2\tB-Chemical\ndid\tO\n,\tO\nhowever\tO\n,\tO\nsignificantly\tO\nsuppress\tO\nCD36\tO\nprotein\tO\nlevels\tO\nas\tO\nmeasured\tO\nby\tO\nfluorescent\tO\nimmunocytochemistry\tO\n.\tO\n\nThis\tO\ndata\tO\nsuggests\tO\nthat\tO\nE2\tB-Chemical\nmodifies\tO\nthe\tO\nexpression\tO\nof\tO\nCD36\tO\nat\tO\nthe\tO\nlevel\tO\nof\tO\nprotein\tO\nexpression\tO\nin\tO\nmonocyte\tO\n-\tO\nderived\tO\nmacrophages\tO\nresulting\tO\nin\tO\nreduced\tO\ncholesteryl\tB-Chemical\nester\tI-Chemical\naccumulation\tO\nfollowing\tO\nritonavir\tB-Chemical\ntreatment\tO\n.\tO\n\nAcute\tO\nhepatitis\tB-Disease\nattack\tO\nafter\tO\nexposure\tO\nto\tO\ntelithromycin\tB-Chemical\n.\tO\n\nINTRODUCTION\tO\n:\tO\nAntibiotic\tO\n-\tO\nassociated\tO\nhepatotoxicity\tB-Disease\nis\tO\nrare\tO\n.\tO\n\nWith\tO\nwidespread\tO\nuse\tO\nof\tO\nantimicrobial\tO\nagents\tO\n,\tO\nhowever\tO\n,\tO\nhepatic\tB-Disease\ninjury\tI-Disease\noccurs\tO\nfrequently\tO\n,\tO\nand\tO\namong\tO\nadverse\tB-Disease\ndrug\tI-Disease\nreactions\tI-Disease\n,\tO\nidiosyncratic\tO\nreactions\tO\nare\tO\nthe\tO\nmost\tO\nserious\tO\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\npatient\tO\n,\tO\nwith\tO\na\tO\nheight\tO\nof\tO\n175\tO\ncm\tO\nand\tO\nweight\tO\nof\tO\n72\tO\nkg\tO\npresented\tO\nto\tO\nMarmara\tO\nUniversity\tO\nHospital\tO\nEmergency\tO\nDepartment\tO\n,\tO\nIstanbul\tO\n,\tO\nTurkey\tO\n,\tO\nwith\tO\n5\tO\ndays\tO\n'\tO\nhistory\tO\nof\tO\njaundice\tB-Disease\n,\tO\nmalaise\tO\n,\tO\nnausea\tB-Disease\n,\tO\nand\tO\nvomiting\tB-Disease\n.\tO\n\nHe\tO\nhad\tO\nbeen\tO\nprescribed\tO\ntelithromycin\tB-Chemical\n400\tO\nmg\tO\n/\tO\nd\tO\nPO\tO\nto\tO\ntreat\tO\nan\tO\nupper\tB-Disease\nrespiratory\tI-Disease\ntract\tI-Disease\ninfection\tI-Disease\n7\tO\ndays\tO\nprior\tO\n.\tO\n\nAdmission\tO\nlaboratory\tO\ntests\tO\nwere\tO\nas\tO\nfollows\tO\n:\tO\nalanine\tB-Chemical\naminotransferase\tO\n,\tO\n67\tO\nU\tO\n/\tO\nL\tO\n(\tO\nreference\tO\nrange\tO\n,\tO\n10\tO\n-\tO\n37\tO\nU\tO\n/\tO\nL\tO\n)\tO\n;\tO\naspartate\tB-Chemical\naminotransferase\tO\n,\tO\n98\tO\nU\tO\n/\tO\nL\tO\n(\tO\n10\tO\n-\tO\n40\tO\nU\tO\n/\tO\nL\tO\n)\tO\n;\tO\nalkaline\tO\nphosphatase\tO\n,\tO\n513\tO\nU\tO\n/\tO\nL\tO\n(\tO\n0\tO\n-\tO\n270\tO\nU\tO\n/\tO\nL\tO\n)\tO\n;\tO\ngamma\tO\n-\tO\nglutamyltransferase\tO\n,\tO\n32\tO\nU\tO\n/\tO\nL\tO\n(\tO\n7\tO\n-\tO\n49\tO\nU\tO\n/\tO\nL\tO\n)\tO\n;\tO\namylase\tO\n,\tO\n46\tO\nU\tO\n/\tO\nL\tO\n(\tO\n0\tO\n-\tO\n220\tO\nU\tO\n/\tO\nL\tO\n)\tO\n;\tO\ntotal\tO\nbilirubin\tB-Chemical\n,\tO\n20\tO\n.\tO\n1\tO\nmg\tO\n/\tO\ndL\tO\n(\tO\n0\tO\n.\tO\n2\tO\n-\tO\n1\tO\n.\tO\n0\tO\nmg\tO\n/\tO\ndL\tO\n)\tO\n;\tO\ndirect\tO\nbilirubin\tB-Chemical\n,\tO\n14\tO\n.\tO\n8\tO\nmg\tO\n/\tO\ndL\tO\n(\tO\n0\tO\n-\tO\n0\tO\n.\tO\n3\tO\nmg\tO\n/\tO\ndL\tO\n)\tO\n;\tO\nand\tO\nalbumin\tO\n,\tO\n4\tO\n.\tO\n7\tO\nmg\tO\n/\tO\ndL\tO\n(\tO\n3\tO\n.\tO\n5\tO\n-\tO\n5\tO\n.\tO\n4\tO\nmg\tO\n/\tO\ndL\tO\n)\tO\n.\tO\n\nNo\tO\ntoxin\tO\n,\tO\nalcohol\tB-Chemical\n,\tO\nor\tO\nother\tO\ndrugs\tO\nwere\tO\nreported\tO\n.\tO\n\nThe\tO\npatient\tO\nhad\tO\nsuffered\tO\na\tO\nprevious\tO\nepisode\tO\nof\tO\n\"\tO\nacute\tO\nhepatitis\tB-Disease\nof\tO\nunknown\tO\norigin\tO\n,\tO\n\"\tO\nthat\tO\noccurred\tO\nafter\tO\ntelithromycin\tB-Chemical\nusage\tO\n.\tO\n\nBoth\tO\nincidents\tO\noccurred\tO\nwithin\tO\na\tO\nyear\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nTelithromycin\tB-Chemical\nis\tO\nthe\tO\nfirst\tO\nof\tO\nthe\tO\nketolide\tO\nantibacterials\tO\nto\tO\nreceive\tO\nUS\tO\nFood\tO\nand\tO\nDrug\tO\nAdministration\tO\napproval\tO\nfor\tO\nclinical\tO\nuse\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\ninfrequent\tO\nand\tO\nusually\tO\nreversible\tO\nsevere\tO\nhepatic\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nBased\tO\non\tO\na\tO\nscore\tO\nof\tO\n8\tO\non\tO\nthe\tO\nNaranjo\tO\nadverse\tB-Disease\ndrug\tI-Disease\nreaction\tI-Disease\nprobability\tO\nscale\tO\n,\tO\ntelithromycin\tB-Chemical\nwas\tO\nthe\tO\nprobable\tO\ncause\tO\nof\tO\nacute\tO\nhepatitis\tB-Disease\nin\tO\nthis\tO\npatient\tO\n,\tO\nand\tO\npathological\tO\nfindings\tO\nsuggested\tO\ndrug\tO\n-\tO\ninduced\tO\ntoxic\tB-Disease\nhepatitis\tI-Disease\n.\tO\n\nRecurrence\tO\nof\tO\nhepatitis\tB-Disease\nattack\tO\nmight\tO\nhave\tO\nbeen\tO\navoided\tO\nif\tO\nthe\tO\ninitial\tO\nincident\tO\nhad\tO\nbeen\tO\ncommunicated\tO\nto\tO\nthe\tO\nattending\tO\nphysician\tO\nwho\tO\nprescribed\tO\ntelithromycin\tB-Chemical\nthe\tO\nsecond\tO\ntime\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nHere\tO\nwe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nacute\tO\nhepatitis\tB-Disease\nprobably\tO\nassociated\tO\nwith\tO\nthe\tO\nadministration\tO\nof\tO\ntelithromycin\tB-Chemical\n.\tO\n\nA\tO\nstudy\tO\non\tO\nthe\tO\neffect\tO\nof\tO\nthe\tO\nduration\tO\nof\tO\nsubcutaneous\tO\nheparin\tB-Chemical\ninjection\tO\non\tO\nbruising\tB-Disease\nand\tO\npain\tB-Disease\n.\tO\n\nAIM\tO\n:\tO\nThis\tO\nstudy\tO\nwas\tO\ncarried\tO\nout\tO\nto\tO\ndetermine\tO\nthe\tO\neffect\tO\nof\tO\ninjection\tO\nduration\tO\non\tO\nbruising\tB-Disease\nand\tO\npain\tB-Disease\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nthe\tO\nsubcutaneous\tO\ninjection\tO\nof\tO\nheparin\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nAlthough\tO\ndifferent\tO\nmethods\tO\nto\tO\nprevent\tO\nbruising\tB-Disease\nand\tO\npain\tB-Disease\nfollowing\tO\nthe\tO\nsubcutaneous\tO\ninjection\tO\nof\tO\nheparin\tB-Chemical\nhave\tO\nbeen\tO\nwidely\tO\nstudied\tO\nand\tO\ndescribed\tO\n,\tO\nthe\tO\neffect\tO\nof\tO\ninjection\tO\nduration\tO\non\tO\nthe\tO\noccurrence\tO\nof\tO\nbruising\tB-Disease\nand\tO\npain\tB-Disease\nis\tO\nlittle\tO\ndocumented\tO\n.\tO\n\nDESIGN\tO\n:\tO\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nas\tO\nwithin\tO\n-\tO\nsubject\tO\n,\tO\nquasi\tO\n-\tO\nexperimental\tO\nresearch\tO\n.\tO\n\nMETHOD\tO\n:\tO\nThe\tO\nsample\tO\nfor\tO\nthe\tO\nstudy\tO\nconsisted\tO\nof\tO\n50\tO\npatients\tO\nto\tO\nwhom\tO\nsubcutaneous\tO\nheparin\tB-Chemical\nwas\tO\nadministered\tO\n.\tO\n\nHeparin\tB-Chemical\nwas\tO\ninjected\tO\nover\tO\n10\tO\nseconds\tO\non\tO\nthe\tO\nright\tO\nabdominal\tO\nsite\tO\nand\tO\n30\tO\nseconds\tO\non\tO\nthe\tO\nleft\tO\nabdominal\tO\nsite\tO\n.\tO\n\nInjections\tO\nareas\tO\nwere\tO\nassessed\tO\nfor\tO\nthe\tO\npresence\tO\nof\tO\nbruising\tB-Disease\nat\tO\n48\tO\nand\tO\n72\tO\nhours\tO\nafter\tO\neach\tO\ninjection\tO\n.\tO\n\nDimensions\tO\nof\tO\nthe\tO\nbruising\tB-Disease\non\tO\nthe\tO\nheparin\tB-Chemical\napplied\tO\nareas\tO\nwere\tO\nmeasured\tO\nusing\tO\ntransparent\tO\nmillimetric\tO\nmeasuring\tO\npaper\tO\n.\tO\n\nThe\tO\nvisual\tO\nanalog\tO\nscale\tO\n(\tO\nVAS\tO\n)\tO\nwas\tO\nused\tO\nto\tO\nmeasure\tO\npain\tB-Disease\nintensity\tO\nand\tO\na\tO\nstop\tO\n-\tO\nwatch\tO\nwas\tO\nused\tO\nto\tO\ntime\tO\nthe\tO\npain\tB-Disease\nperiod\tO\n.\tO\n\nData\tO\nwere\tO\nanalysed\tO\nusing\tO\nchi\tO\n-\tO\nsquare\tO\ntest\tO\n,\tO\nMann\tO\n-\tO\nWhitney\tO\nU\tO\n,\tO\nWilcoxon\tO\nsigned\tO\nranks\tO\ntests\tO\nand\tO\ncorrelation\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\npercentage\tO\nof\tO\nbruising\tB-Disease\noccurrence\tO\nwas\tO\n64\tO\n%\tO\nwith\tO\nthe\tO\ninjection\tO\nof\tO\n10\tO\nseconds\tO\nduration\tO\nand\tO\n42\tO\n%\tO\nin\tO\nthe\tO\n30\tO\n-\tO\nsecond\tO\ninjection\tO\n.\tO\n\nIt\tO\nwas\tO\ndetermined\tO\nthat\tO\nthe\tO\nsize\tO\nof\tO\nthe\tO\nbruising\tB-Disease\nwas\tO\nsmaller\tO\nin\tO\nthe\tO\n30\tO\n-\tO\nsecond\tO\ninjection\tO\n.\tO\n\nPain\tB-Disease\nintensity\tO\nand\tO\npain\tB-Disease\nperiod\tO\nwere\tO\nstatistically\tO\nsignificantly\tO\nlower\tO\nfor\tO\nthe\tO\n30\tO\n-\tO\nsecond\tO\ninjection\tO\nthan\tO\nfor\tO\nthe\tO\n10\tO\n-\tO\nsecond\tO\ninjection\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nIt\tO\nwas\tO\ndetermined\tO\nthat\tO\ninjection\tO\nduration\tO\nhad\tO\nan\tO\neffect\tO\non\tO\nbruising\tB-Disease\nand\tO\npain\tB-Disease\nfollowing\tO\nthe\tO\nsubcutaneous\tO\nadministration\tO\nof\tO\nheparin\tB-Chemical\n.\tO\n\nThis\tO\nstudy\tO\nshould\tO\nbe\tO\nrepeated\tO\non\tO\na\tO\nlarger\tO\nsample\tO\n.\tO\n\nRELEVANCE\tO\nTO\tO\nCLINICAL\tO\nPRACTICE\tO\n:\tO\nWhen\tO\nadministering\tO\nsubcutaneous\tO\nheparin\tB-Chemical\ninjections\tO\n,\tO\nit\tO\nis\tO\nimportant\tO\nto\tO\nextend\tO\nthe\tO\nduration\tO\nof\tO\nthe\tO\ninjection\tO\n.\tO\n\nAcute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\nin\tO\ntwo\tO\npatients\tO\nwith\tO\nregular\tO\nalcohol\tB-Chemical\nconsumption\tO\ningesting\tO\nparacetamol\tB-Chemical\nat\tO\ntherapeutic\tO\ndosage\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\npossible\tO\nrole\tO\nof\tO\nalcohol\tB-Chemical\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nhepatotoxicity\tB-Disease\nassociated\tO\nwith\tO\ntherapeutic\tO\ndoses\tO\nof\tO\nparacetamol\tB-Chemical\n(\tO\nacetaminophen\tB-Chemical\n)\tO\nis\tO\ncurrently\tO\ndebated\tO\n.\tO\n\nCASE\tO\nREPORT\tO\n:\tO\nWe\tO\ndescribe\tO\n2\tO\npatients\tO\nwho\tO\nwere\tO\nregular\tO\nconsumers\tO\nof\tO\nalcohol\tB-Chemical\nand\tO\nwho\tO\ndeveloped\tO\nliver\tB-Disease\nfailure\tI-Disease\nwithin\tO\n3\tO\n-\tO\n5\tO\ndays\tO\nafter\tO\nhospitalization\tO\nand\tO\nstopping\tO\nalcohol\tB-Chemical\nconsumption\tO\nwhile\tO\nbeing\tO\ntreated\tO\nwith\tO\n4\tO\ng\tO\nparacetamol\tB-Chemical\n/\tO\nday\tO\n.\tO\n\nA\tO\nparacetamol\tB-Chemical\nserum\tO\nlevel\tO\nobtained\tO\nin\tO\none\tO\nof\tO\nthese\tO\npatients\tO\nwas\tO\nnot\tO\nin\tO\nthe\tO\ntoxic\tO\nrange\tO\n.\tO\n\nPossible\tO\nrisk\tO\nfactors\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nhepatotoxicity\tB-Disease\nin\tO\npatients\tO\ntreated\tO\nwith\tO\ntherapeutic\tO\ndoses\tO\nof\tO\nparacetamol\tB-Chemical\nare\tO\ndiscussed\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\npatients\tO\nwith\tO\nrisk\tO\nfactors\tO\n,\tO\ne\tO\n.\tO\ng\tO\n.\tO\nregular\tO\nconsumption\tO\nof\tO\nalcohol\tB-Chemical\n,\tO\nliver\tB-Disease\nfailure\tI-Disease\nis\tO\npossible\tO\nwhen\tO\ntherapeutic\tO\ndoses\tO\nare\tO\ningested\tO\n.\tO\n\nWe\tO\npropose\tO\nthat\tO\nthe\tO\nparacetamol\tB-Chemical\ndose\tO\nshould\tO\nnot\tO\nexceed\tO\n2\tO\ng\tO\n/\tO\nday\tO\nin\tO\nsuch\tO\npatients\tO\nand\tO\nthat\tO\ntheir\tO\nliver\tO\nfunction\tO\nshould\tO\nbe\tO\nmonitored\tO\nclosely\tO\nwhile\tO\nbeing\tO\ntreated\tO\nwith\tO\nparacetamol\tB-Chemical\n.\tO\n\nAssociations\tO\nbetween\tO\nuse\tO\nof\tO\nbenzodiazepines\tB-Chemical\nor\tO\nrelated\tO\ndrugs\tO\nand\tO\nhealth\tO\n,\tO\nphysical\tO\nabilities\tO\nand\tO\ncognitive\tO\nfunction\tO\n:\tO\na\tO\nnon\tO\n-\tO\nrandomised\tO\nclinical\tO\nstudy\tO\nin\tO\nthe\tO\nelderly\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\nassociations\tO\nbetween\tO\nthe\tO\nuse\tO\nof\tO\nbenzodiazepines\tB-Chemical\nor\tO\nrelated\tO\ndrugs\tO\n(\tO\nBZDs\tB-Chemical\n/\tO\nRDs\tO\n)\tO\nand\tO\nhealth\tO\n,\tO\nfunctional\tO\nabilities\tO\nand\tO\ncognitive\tO\nfunction\tO\nin\tO\nthe\tO\nelderly\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nnon\tO\n-\tO\nrandomised\tO\nclinical\tO\nstudy\tO\nof\tO\npatients\tO\naged\tO\n>\tO\nor\tO\n=\tO\n65\tO\nyears\tO\nadmitted\tO\nto\tO\nacute\tO\nhospital\tO\nwards\tO\nduring\tO\n1\tO\nmonth\tO\n.\tO\n\n164\tO\npatients\tO\n(\tO\nmean\tO\nage\tO\n+\tO\n/\tO\n-\tO\nstandard\tO\ndeviation\tO\n[\tO\nSD\tO\n]\tO\n81\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n8\tO\nyears\tO\n)\tO\nwere\tO\nadmitted\tO\n.\tO\n\nOf\tO\nthese\tO\n,\tO\nnearly\tO\nhalf\tO\n(\tO\nn\tO\n=\tO\n78\tO\n)\tO\nhad\tO\nused\tO\nBZDs\tB-Chemical\n/\tO\nRDs\tO\nbefore\tO\nadmission\tO\n,\tO\nand\tO\nthe\tO\nremainder\tO\n(\tO\nn\tO\n=\tO\n86\tO\n)\tO\nwere\tO\nnon\tO\n-\tO\nusers\tO\n.\tO\n\nCognitive\tO\nability\tO\nwas\tO\nassessed\tO\nby\tO\nthe\tO\nMini\tO\n-\tO\nMental\tO\nState\tO\nExamination\tO\n(\tO\nMMSE\tO\n)\tO\n.\tO\n\nPatients\tO\nscoring\tO\n>\tO\nor\tO\n=\tO\n20\tO\nMMSE\tO\nsum\tO\npoints\tO\nwere\tO\ninterviewed\tO\n(\tO\nn\tO\n=\tO\n79\tO\n)\tO\nand\tO\nquestioned\tO\nregarding\tO\nsymptoms\tO\nand\tO\nfunctional\tO\nabilities\tO\nduring\tO\nthe\tO\nweek\tO\nprior\tO\nto\tO\nadmission\tO\n.\tO\n\nData\tO\non\tO\nuse\tO\nof\tO\nBZDs\tB-Chemical\n/\tO\nRDs\tO\nbefore\tO\nadmission\tO\n,\tO\ncurrent\tO\nmedications\tO\nand\tO\ndischarge\tO\ndiagnoses\tO\nwere\tO\ncollected\tO\nfrom\tO\nmedical\tO\nrecords\tO\n.\tO\n\nHealth\tO\n,\tO\nphysical\tO\nabilities\tO\nand\tO\ncognitive\tO\nfunction\tO\nwere\tO\ncompared\tO\nbetween\tO\nBZD\tO\n/\tO\nRD\tO\nusers\tO\nand\tO\nnon\tO\n-\tO\nusers\tO\n,\tO\nand\tO\nadjustments\tO\nwere\tO\nmade\tO\nfor\tO\nconfounding\tO\nvariables\tO\n.\tO\n\nThe\tO\nresidual\tO\nserum\tO\nconcentrations\tO\nof\tO\noxazepam\tB-Chemical\n,\tO\ntemazepam\tB-Chemical\nand\tO\nzopiclone\tB-Chemical\nwere\tO\nanalysed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\nduration\tO\nof\tO\nBZD\tO\n/\tO\nRD\tO\nuse\tO\nwas\tO\n7\tO\n+\tO\n/\tO\n-\tO\n7\tO\nyears\tO\n(\tO\nrange\tO\n1\tO\n-\tO\n31\tO\n)\tO\n.\tO\n\nTwo\tO\nor\tO\nthree\tO\nBZDs\tB-Chemical\n/\tO\nRDs\tO\nwere\tO\nconcomitantly\tO\ntaken\tO\nby\tO\n26\tO\n%\tO\nof\tO\nusers\tO\n(\tO\nn\tO\n=\tO\n20\tO\n)\tO\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nthese\tO\ndrugs\tO\nwas\tO\nassociated\tO\nwith\tO\nfemale\tO\nsex\tO\nand\tO\nuse\tO\nof\tO\na\tO\nhigher\tO\nnumber\tO\nof\tO\ndrugs\tO\nwith\tO\neffects\tO\non\tO\nthe\tO\nCNS\tO\n,\tO\nwhich\tO\ntended\tO\nto\tO\nbe\tO\nrelated\tO\nto\tO\ndiagnosed\tO\ndementia\tB-Disease\n.\tO\n\nAfter\tO\nadjustment\tO\nfor\tO\nthese\tO\nvariables\tO\nas\tO\nconfounders\tO\n,\tO\nuse\tO\nof\tO\nBZDs\tB-Chemical\n/\tO\nRDs\tO\nwas\tO\nnot\tO\nassociated\tO\nwith\tO\ncognitive\tO\nfunction\tO\nas\tO\nmeasured\tO\nby\tO\nthe\tO\nMMSE\tO\n.\tO\n\nHowever\tO\n,\tO\nuse\tO\nof\tO\nBZDs\tB-Chemical\n/\tO\nRDs\tO\nwas\tO\nassociated\tO\nwith\tO\ndizziness\tB-Disease\n,\tO\ninability\tB-Disease\nto\tI-Disease\nsleep\tI-Disease\nafter\tO\nawaking\tO\nat\tO\nnight\tO\nand\tO\ntiredness\tB-Disease\nin\tO\nthe\tO\nmornings\tO\nduring\tO\nthe\tO\nweek\tO\nprior\tO\nto\tO\nadmission\tO\nand\tO\nwith\tO\nstronger\tO\ndepressive\tB-Disease\nsymptoms\tI-Disease\nmeasured\tO\nat\tO\nthe\tO\nbeginning\tO\nof\tO\nthe\tO\nhospital\tO\nstay\tO\n.\tO\n\nUse\tO\nof\tO\nBZDs\tB-Chemical\n/\tO\nRDs\tO\ntended\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\na\tO\nreduced\tO\nability\tO\nto\tO\nwalk\tO\nand\tO\nshorter\tO\nnight\tO\n-\tO\ntime\tO\nsleep\tO\nduring\tO\nthe\tO\nweek\tO\nprior\tO\nto\tO\nadmission\tO\n.\tO\n\nA\tO\nhigher\tO\nresidual\tO\nserum\tO\nconcentration\tO\nof\tO\ntemazepam\tB-Chemical\ncorrelated\tO\nwith\tO\na\tO\nlower\tO\nMMSE\tO\nsum\tO\nscore\tO\nafter\tO\nadjustment\tO\nfor\tO\nconfounding\tO\nvariables\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nLong\tO\n-\tO\nterm\tO\nuse\tO\nand\tO\nconcomitant\tO\nuse\tO\nof\tO\nmore\tO\nthan\tO\none\tO\nBZD\tO\n/\tO\nRD\tO\nwere\tO\ncommon\tO\nin\tO\nelderly\tO\npatients\tO\nhospitalised\tO\nbecause\tO\nof\tO\nacute\tO\nillnesses\tO\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nuse\tO\nwas\tO\nassociated\tO\nwith\tO\ndaytime\tO\nand\tO\nnight\tO\n-\tO\ntime\tO\nsymptoms\tO\nindicative\tO\nof\tO\npoorer\tO\nhealth\tO\nand\tO\npotentially\tO\ncaused\tO\nby\tO\nthe\tO\nadverse\tO\neffects\tO\nof\tO\nthese\tO\ndrugs\tO\n.\tO\n\nAcute\tO\nvocal\tB-Disease\nfold\tI-Disease\npalsy\tI-Disease\nafter\tO\nacute\tO\ndisulfiram\tB-Chemical\nintoxication\tO\n.\tO\n\nAcute\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\ncaused\tO\nby\tO\na\tO\ndisulfiram\tB-Chemical\noverdose\tB-Disease\nis\tO\nvery\tO\nrare\tO\nand\tO\nthere\tO\nis\tO\nno\tO\nreport\tO\nof\tO\nit\tO\nleading\tO\nto\tO\nvocal\tB-Disease\nfold\tI-Disease\npalsy\tI-Disease\n.\tO\n\nA\tO\n49\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwas\tO\ntransferred\tO\nto\tO\nour\tO\ndepartment\tO\nbecause\tO\nof\tO\nquadriparesis\tB-Disease\n,\tO\nlancinating\tO\npain\tB-Disease\n,\tO\nsensory\tB-Disease\nloss\tI-Disease\n,\tO\nand\tO\nparesthesia\tB-Disease\nof\tO\nthe\tO\ndistal\tO\nlimbs\tO\n.\tO\n\nOne\tO\nmonth\tO\npreviously\tO\n,\tO\nshe\tO\nhad\tO\ntaken\tO\na\tO\nsingle\tO\nhigh\tO\ndose\tO\nof\tO\ndisulfiram\tB-Chemical\n(\tO\n130\tO\ntablets\tO\nof\tO\nALCOHOL\tB-Chemical\nSTOP\tO\nTAB\tO\n,\tO\nShin\tO\n-\tO\nPoong\tO\nPharm\tO\n.\tO\nCo\tO\n.\tO\n,\tO\nAnsan\tO\n,\tO\nKorea\tO\n)\tO\nin\tO\na\tO\nsuicide\tO\nattempt\tO\n.\tO\n\nShe\tO\nwas\tO\nnot\tO\nan\tO\nalcoholic\tO\n.\tO\n\nFor\tO\nthe\tO\nfirst\tO\nfew\tO\ndays\tO\nafter\tO\ningestion\tO\n,\tO\nshe\tO\nwas\tO\nin\tO\na\tO\nconfused\tO\nstate\tO\nand\tO\nhad\tO\nmild\tO\nto\tO\nmoderate\tO\nataxia\tB-Disease\nand\tO\ngiddiness\tB-Disease\n.\tO\n\nShe\tO\nnoticed\tO\nhoarseness\tB-Disease\nand\tO\ndistally\tO\naccentuated\tO\nmotor\tO\nand\tO\nsensory\tO\ndysfunction\tO\nafter\tO\nshe\tO\nhad\tO\nrecovered\tO\nfrom\tO\nthis\tO\nstate\tO\n.\tO\n\nA\tO\nnerve\tO\nconduction\tO\nstudy\tO\nwas\tO\nconsistent\tO\nwith\tO\nsevere\tO\nsensorimotor\tO\naxonal\tO\npolyneuropathy\tB-Disease\n.\tO\n\nLaryngeal\tO\nelectromyography\tO\n(\tO\nthyroarytenoid\tO\nmuscle\tO\n)\tO\nshowed\tO\nample\tO\ndenervation\tO\npotentials\tO\n.\tO\n\nLaryngoscopy\tO\nrevealed\tO\nasymmetric\tO\nvocal\tO\nfold\tO\nmovements\tO\nduring\tO\nphonation\tO\n.\tO\n\nHer\tO\nvocal\tO\nchange\tO\nand\tO\nweakness\tO\nbegan\tO\nto\tO\nimprove\tO\nspontaneously\tO\nabout\tO\n3\tO\nweeks\tO\nafter\tO\ntransfer\tO\n.\tO\n\nThis\tO\nwas\tO\na\tO\ncase\tO\nof\tO\nacute\tO\npalsy\tB-Disease\nof\tO\nthe\tO\nrecurrent\tO\nlaryngeal\tO\nnerve\tO\nand\tO\nsuperimposed\tO\nsevere\tO\nacute\tO\nsensorimotor\tO\naxonal\tO\npolyneuropathy\tB-Disease\ncaused\tO\nby\tO\nhigh\tO\n-\tO\ndose\tO\ndisulfiram\tB-Chemical\nintoxication\tO\n.\tO\n\nEncephalopathy\tB-Disease\ninduced\tO\nby\tO\nlevetiracetam\tB-Chemical\nadded\tO\nto\tO\nvalproate\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nWe\tO\nreport\tO\non\tO\nthe\tO\nmanifestation\tO\nof\tO\na\tO\nlevetiracetam\tB-Chemical\n(\tO\nLEV\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\n.\tO\n\nFINDINGS\tO\n:\tO\nA\tO\n28\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nsuffering\tO\nfrom\tO\nidiopathic\tB-Disease\nepilepsy\tI-Disease\nwith\tO\ngeneralized\tO\nseizures\tB-Disease\nwas\tO\ntreated\tO\nwith\tO\nLEV\tB-Chemical\n(\tO\n3000\tO\nmg\tO\n)\tO\nadded\tO\nto\tO\nvalproate\tB-Chemical\n(\tO\nVPA\tB-Chemical\n)\tO\n(\tO\n2000\tO\nmg\tO\n)\tO\n.\tO\n\nFrequency\tO\nof\tO\ngeneralized\tO\ntonic\tB-Disease\n-\tI-Disease\nclonic\tI-Disease\nseizures\tI-Disease\nincreased\tO\nfrom\tO\none\tO\nper\tO\n6\tO\nmonths\tO\nto\tO\ntwo\tO\nper\tO\nmonth\tO\n.\tO\n\nNeuropsychological\tO\ntesting\tO\nshowed\tO\nimpaired\tB-Disease\nword\tI-Disease\nfluency\tI-Disease\n,\tI-Disease\npsychomotor\tI-Disease\nspeed\tI-Disease\nand\tI-Disease\nworking\tI-Disease\nmemory\tI-Disease\n.\tO\n\nThe\tO\ninterictal\tO\nelectroencephalogram\tO\n(\tO\nEEG\tO\n)\tO\nshowed\tO\na\tO\ngeneralized\tO\nslowing\tO\nto\tO\n5\tO\nper\tO\nsecond\tO\ntheta\tO\nrhythms\tO\nwith\tO\nbilateral\tO\ngeneralized\tO\nhigh\tO\n-\tO\namplitude\tO\ndischarges\tO\n.\tO\n\nOUTCOME\tO\n:\tO\nFollowing\tO\ndiscontinuation\tO\nof\tO\nLEV\tB-Chemical\n,\tO\nEEG\tO\nand\tO\nneuropsychological\tO\nfindings\tO\nimproved\tO\nand\tO\nseizure\tB-Disease\nfrequency\tO\ndecreased\tO\n.\tO\n\nNorepinephrine\tB-Chemical\nsignaling\tO\nthrough\tO\nbeta\tO\n-\tO\nadrenergic\tO\nreceptors\tO\nis\tO\ncritical\tO\nfor\tO\nexpression\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nanxiety\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nCocaine\tB-Chemical\nis\tO\na\tO\nwidely\tO\nabused\tO\npsychostimulant\tO\nthat\tO\nhas\tO\nboth\tO\nrewarding\tO\nand\tO\naversive\tO\nproperties\tO\n.\tO\n\nWhile\tO\nthe\tO\nmechanisms\tO\nunderlying\tO\ncocaine\tB-Chemical\n'\tO\ns\tO\nrewarding\tO\neffects\tO\nhave\tO\nbeen\tO\nstudied\tO\nextensively\tO\n,\tO\nless\tO\nattention\tO\nhas\tO\nbeen\tO\npaid\tO\nto\tO\nthe\tO\nunpleasant\tO\nbehavioral\tO\nstates\tO\ninduced\tO\nby\tO\ncocaine\tB-Chemical\n,\tO\nsuch\tO\nas\tO\nanxiety\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\nevaluated\tO\nthe\tO\nperformance\tO\nof\tO\ndopamine\tB-Chemical\nbeta\tO\n-\tO\nhydroxylase\tO\nknockout\tO\n(\tO\nDbh\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n,\tO\nwhich\tO\nlack\tO\nnorepinephrine\tB-Chemical\n(\tO\nNE\tB-Chemical\n)\tO\n,\tO\nin\tO\nthe\tO\nelevated\tO\nplus\tO\nmaze\tO\n(\tO\nEPM\tO\n)\tO\nto\tO\nexamine\tO\nthe\tO\ncontribution\tO\nof\tO\nnoradrenergic\tO\nsignaling\tO\nto\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nanxiety\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nfound\tO\nthat\tO\ncocaine\tB-Chemical\ndose\tO\n-\tO\ndependently\tO\nincreased\tO\nanxiety\tB-Disease\n-\tO\nlike\tO\nbehavior\tO\nin\tO\ncontrol\tO\n(\tO\nDbh\tO\n+\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n,\tO\nas\tO\nmeasured\tO\nby\tO\na\tO\ndecrease\tO\nin\tO\nopen\tO\narm\tO\nexploration\tO\n.\tO\n\nThe\tO\nDbh\tO\n-\tO\n/\tO\n-\tO\nmice\tO\nhad\tO\nnormal\tO\nbaseline\tO\nperformance\tO\nin\tO\nthe\tO\nEPM\tO\nbut\tO\nwere\tO\ncompletely\tO\nresistant\tO\nto\tO\nthe\tO\nanxiogenic\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nCocaine\tB-Chemical\n-\tO\ninduced\tO\nanxiety\tB-Disease\nwas\tO\nalso\tO\nattenuated\tO\nin\tO\nDbh\tO\n+\tO\n/\tO\n-\tO\nmice\tO\nfollowing\tO\nadministration\tO\nof\tO\ndisulfiram\tB-Chemical\n,\tO\na\tO\ndopamine\tB-Chemical\nbeta\tO\n-\tO\nhydroxylase\tO\n(\tO\nDBH\tO\n)\tO\ninhibitor\tO\n.\tO\n\nIn\tO\nexperiments\tO\nusing\tO\nspecific\tO\nadrenergic\tO\nantagonists\tO\n,\tO\nwe\tO\nfound\tO\nthat\tO\npretreatment\tO\nwith\tO\nthe\tO\nbeta\tO\n-\tO\nadrenergic\tO\nreceptor\tO\nantagonist\tO\npropranolol\tB-Chemical\nblocked\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nanxiety\tB-Disease\n-\tO\nlike\tO\nbehavior\tO\nin\tO\nDbh\tO\n+\tO\n/\tO\n-\tO\nand\tO\nwild\tO\n-\tO\ntype\tO\nC57BL6\tO\n/\tO\nJ\tO\nmice\tO\n,\tO\nwhile\tO\nthe\tO\nalpha\tO\n(\tO\n1\tO\n)\tO\nantagonist\tO\nprazosin\tB-Chemical\nand\tO\nthe\tO\nalpha\tO\n(\tO\n2\tO\n)\tO\nantagonist\tO\nyohimbine\tB-Chemical\nhad\tO\nno\tO\neffect\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nnoradrenergic\tO\nsignaling\tO\nvia\tO\nbeta\tO\n-\tO\nadrenergic\tO\nreceptors\tO\nis\tO\nrequired\tO\nfor\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nanxiety\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nHypothalamic\tO\nprolactin\tO\nreceptor\tO\nmessenger\tO\nribonucleic\tB-Chemical\nacid\tI-Chemical\nlevels\tO\n,\tO\nprolactin\tO\nsignaling\tO\n,\tO\nand\tO\nhyperprolactinemic\tB-Disease\ninhibition\tO\nof\tO\npulsatile\tO\nluteinizing\tO\nhormone\tO\nsecretion\tO\nare\tO\ndependent\tO\non\tO\nestradiol\tB-Chemical\n.\tO\n\nHyperprolactinemia\tB-Disease\ncan\tO\nreduce\tO\nfertility\tO\nand\tO\nlibido\tO\n.\tO\n\nAlthough\tO\ncentral\tO\nprolactin\tO\nactions\tO\nare\tO\nthought\tO\nto\tO\ncontribute\tO\nto\tO\nthis\tO\n,\tO\nthe\tO\nmechanisms\tO\nare\tO\npoorly\tO\nunderstood\tO\n.\tO\n\nWe\tO\nfirst\tO\ntested\tO\nwhether\tO\nchronic\tO\nhyperprolactinemia\tB-Disease\ninhibited\tO\ntwo\tO\nneuroendocrine\tO\nparameters\tO\nnecessary\tO\nfor\tO\nfemale\tO\nfertility\tO\n:\tO\npulsatile\tO\nLH\tO\nsecretion\tO\nand\tO\nthe\tO\nestrogen\tB-Chemical\n-\tO\ninduced\tO\nLH\tO\nsurge\tO\n.\tO\n\nChronic\tO\nhyperprolactinemia\tB-Disease\ninduced\tO\nby\tO\nthe\tO\ndopamine\tB-Chemical\nantagonist\tO\nsulpiride\tB-Chemical\ncaused\tO\na\tO\n40\tO\n%\tO\nreduction\tO\nLH\tO\npulse\tO\nfrequency\tO\nin\tO\novariectomized\tO\nrats\tO\n,\tO\nbut\tO\nonly\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nchronic\tO\nlow\tO\nlevels\tO\nof\tO\nestradiol\tB-Chemical\n.\tO\n\nSulpiride\tB-Chemical\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nmagnitude\tO\nof\tO\na\tO\nsteroid\tB-Chemical\n-\tO\ninduced\tO\nLH\tO\nsurge\tO\nor\tO\nthe\tO\npercentage\tO\nof\tO\nGnRH\tO\nneurons\tO\nactivated\tO\nduring\tO\nthe\tO\nsurge\tO\n.\tO\n\nEstradiol\tB-Chemical\nis\tO\nknown\tO\nto\tO\ninfluence\tO\nexpression\tO\nof\tO\nthe\tO\nlong\tO\nform\tO\nof\tO\nprolactin\tO\nreceptors\tO\n(\tO\nPRL\tO\n-\tO\nR\tO\n)\tO\nand\tO\ncomponents\tO\nof\tO\nprolactin\tO\n'\tO\ns\tO\nsignaling\tO\npathway\tO\n.\tO\n\nTo\tO\ntest\tO\nthe\tO\nhypothesis\tO\nthat\tO\nestrogen\tB-Chemical\nincreases\tO\nPRL\tO\n-\tO\nR\tO\nexpression\tO\nand\tO\nsensitivity\tO\nto\tO\nprolactin\tO\n,\tO\nwe\tO\nnext\tO\ndemonstrated\tO\nthat\tO\nestradiol\tB-Chemical\ngreatly\tO\naugments\tO\nprolactin\tO\n-\tO\ninduced\tO\nSTAT5\tO\nactivation\tO\n.\tO\n\nLastly\tO\n,\tO\nwe\tO\nmeasured\tO\nPRL\tO\n-\tO\nR\tO\nand\tO\nsuppressor\tO\nof\tO\ncytokine\tO\nsignaling\tO\n(\tO\nSOCS\tO\n-\tO\n1\tO\nand\tO\n-\tO\n3\tO\nand\tO\nCIS\tO\n,\tO\nwhich\tO\nreflect\tO\nthe\tO\nlevel\tO\nof\tO\nprolactin\tO\nsignaling\tO\n)\tO\nmRNAs\tO\nin\tO\nresponse\tO\nto\tO\nsulpiride\tB-Chemical\nand\tO\nestradiol\tB-Chemical\n.\tO\n\nSulpiride\tB-Chemical\ninduced\tO\nonly\tO\nSOCS\tO\n-\tO\n1\tO\nin\tO\nthe\tO\nmedial\tO\npreoptic\tO\narea\tO\n,\tO\nwhere\tO\nGnRH\tO\nneurons\tO\nare\tO\nregulated\tO\n,\tO\nbut\tO\nin\tO\nthe\tO\narcuate\tO\nnucleus\tO\nand\tO\nchoroid\tO\nplexus\tO\n,\tO\nPRL\tO\n-\tO\nR\tO\n,\tO\nSOCS\tO\n-\tO\n3\tO\n,\tO\nand\tO\nCIS\tO\nmRNA\tO\nlevels\tO\nwere\tO\nalso\tO\ninduced\tO\n.\tO\n\nEstradiol\tB-Chemical\nenhanced\tO\nthese\tO\neffects\tO\non\tO\nSOCS\tO\n-\tO\n3\tO\nand\tO\nCIS\tO\n.\tO\n\nInterestingly\tO\n,\tO\nestradiol\tB-Chemical\nalso\tO\ninduced\tO\nPRL\tO\n-\tO\nR\tO\n,\tO\nSOCS\tO\n-\tO\n3\tO\n,\tO\nand\tO\nCIS\tO\nmRNA\tO\nlevels\tO\nindependently\tO\n.\tO\n\nThese\tO\ndata\tO\nshow\tO\nthat\tO\nGnRH\tO\npulse\tO\nfrequency\tO\nis\tO\ninhibited\tO\nby\tO\nchronic\tO\nhyperprolactinemia\tB-Disease\nin\tO\na\tO\nsteroid\tB-Chemical\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nThey\tO\nalso\tO\nprovide\tO\nevidence\tO\nfor\tO\nestradiol\tB-Chemical\n-\tO\ndependent\tO\nand\tO\nbrain\tO\nregion\tO\n-\tO\nspecific\tO\nregulation\tO\nof\tO\nPRL\tO\n-\tO\nR\tO\nexpression\tO\nand\tO\nsignaling\tO\nresponses\tO\nby\tO\nprolactin\tO\n.\tO\n\nClonidine\tB-Chemical\nfor\tO\nattention\tB-Disease\n-\tI-Disease\ndeficit\tI-Disease\n/\tI-Disease\nhyperactivity\tI-Disease\ndisorder\tI-Disease\n:\tO\nII\tO\n.\tO\n\nECG\tO\nchanges\tO\nand\tO\nadverse\tO\nevents\tO\nanalysis\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nexamine\tO\nthe\tO\nsafety\tO\nand\tO\ntolerability\tO\nof\tO\nclonidine\tB-Chemical\nused\tO\nalone\tO\nor\tO\nwith\tO\nmethylphenidate\tB-Chemical\nin\tO\nchildren\tO\nwith\tO\nattention\tB-Disease\n-\tI-Disease\ndeficit\tI-Disease\n/\tI-Disease\nhyperactivity\tI-Disease\ndisorder\tI-Disease\n(\tO\nADHD\tB-Disease\n)\tO\n.\tO\n\nMETHOD\tO\n:\tO\nIn\tO\na\tO\n16\tO\n-\tO\nweek\tO\nmulticenter\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\ntrial\tO\n,\tO\n122\tO\nchildren\tO\nwith\tO\nADHD\tB-Disease\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nclonidine\tB-Chemical\n(\tO\nn\tO\n=\tO\n31\tO\n)\tO\n,\tO\nmethylphenidate\tB-Chemical\n(\tO\nn\tO\n=\tO\n29\tO\n)\tO\n,\tO\nclonidine\tB-Chemical\nand\tO\nmethylphenidate\tB-Chemical\n(\tO\nn\tO\n=\tO\n32\tO\n)\tO\n,\tO\nor\tO\nplacebo\tO\n(\tO\nn\tO\n=\tO\n30\tO\n)\tO\n.\tO\n\nDoses\tO\nwere\tO\nflexibly\tO\ntitrated\tO\nup\tO\nto\tO\n0\tO\n.\tO\n6\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\nclonidine\tB-Chemical\nand\tO\n60\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\nmethylphenidate\tB-Chemical\n(\tO\nboth\tO\nwith\tO\ndivided\tO\ndosing\tO\n)\tO\n.\tO\n\nGroups\tO\nwere\tO\ncompared\tO\nregarding\tO\nadverse\tO\nevents\tO\nand\tO\nchanges\tO\nfrom\tO\nbaseline\tO\nto\tO\nweek\tO\n16\tO\nin\tO\nelectrocardiograms\tO\nand\tO\nvital\tO\nsigns\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThere\tO\nwere\tO\nmore\tO\nincidents\tO\nof\tO\nbradycardia\tB-Disease\nin\tO\nsubjects\tO\ntreated\tO\nwith\tO\nclonidine\tB-Chemical\ncompared\tO\nwith\tO\nthose\tO\nnot\tO\ntreated\tO\nwith\tO\nclonidine\tB-Chemical\n(\tO\n17\tO\n.\tO\n5\tO\n%\tO\nversus\tO\n3\tO\n.\tO\n4\tO\n%\tO\n;\tO\np\tO\n=\tO\n.\tO\n02\tO\n)\tO\n,\tO\nbut\tO\nno\tO\nother\tO\nsignificant\tO\ngroup\tO\ndifferences\tO\nregarding\tO\nelectrocardiogram\tO\nand\tO\nother\tO\ncardiovascular\tO\noutcomes\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nsuggestions\tO\nof\tO\ninteractions\tO\nbetween\tO\nclonidine\tB-Chemical\nand\tO\nmethylphenidate\tB-Chemical\nregarding\tO\ncardiovascular\tO\noutcomes\tO\n.\tO\n\nModerate\tO\nor\tO\nsevere\tO\nadverse\tO\nevents\tO\nwere\tO\nmore\tO\ncommon\tO\nin\tO\nsubjects\tO\non\tO\nclonidine\tB-Chemical\n(\tO\n79\tO\n.\tO\n4\tO\n%\tO\nversus\tO\n49\tO\n.\tO\n2\tO\n%\tO\n;\tO\np\tO\n=\tO\n.\tO\n0006\tO\n)\tO\nbut\tO\nnot\tO\nassociated\tO\nwith\tO\nhigher\tO\nrates\tO\nof\tO\nearly\tO\nstudy\tO\nwithdrawal\tO\n.\tO\n\nDrowsiness\tB-Disease\nwas\tO\ncommon\tO\non\tO\nclonidine\tB-Chemical\n,\tO\nbut\tO\ngenerally\tO\nresolved\tO\nby\tO\n6\tO\nto\tO\n8\tO\nweeks\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nClonidine\tB-Chemical\n,\tO\nused\tO\nalone\tO\nor\tO\nwith\tO\nmethylphenidate\tB-Chemical\n,\tO\nappears\tO\nsafe\tO\nand\tO\nwell\tO\ntolerated\tO\nin\tO\nchildhood\tO\nADHD\tB-Disease\n.\tO\n\nPhysicians\tO\nprescribing\tO\nclonidine\tB-Chemical\nshould\tO\nmonitor\tO\nfor\tO\nbradycardia\tB-Disease\nand\tO\nadvise\tO\npatients\tO\nabout\tO\nthe\tO\nhigh\tO\nlikelihood\tO\nof\tO\ninitial\tO\ndrowsiness\tB-Disease\n.\tO\n\nRenal\tB-Disease\nFanconi\tI-Disease\nsyndrome\tI-Disease\nand\tO\nmyopathy\tB-Disease\nafter\tO\nliver\tO\ntransplantation\tO\n:\tO\ndrug\tO\n-\tO\nrelated\tO\nmitochondrial\tB-Disease\ncytopathy\tI-Disease\n?\tO\n\nAdvances\tO\nin\tO\nthe\tO\nfield\tO\nof\tO\ntransplantation\tO\nprovide\tO\na\tO\nbetter\tO\nquality\tO\nof\tO\nlife\tO\nand\tO\nallow\tO\nmore\tO\nfavorable\tO\nconditions\tO\nfor\tO\ngrowth\tO\nand\tO\ndevelopment\tO\nin\tO\nchildren\tO\n.\tO\n\nHowever\tO\n,\tO\ncombinations\tO\nof\tO\ndifferent\tO\ntherapeutic\tO\nregimens\tO\nrequire\tO\nconsideration\tO\nof\tO\npotential\tO\nadverse\tO\nreactions\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n15\tO\n-\tO\nyr\tO\n-\tO\nold\tO\ngirl\tO\nwho\tO\nhad\tO\northotopic\tO\nliver\tO\ntransplantation\tO\nbecause\tO\nof\tO\nWilson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nTacrolimus\tB-Chemical\n,\tO\nMMF\tB-Chemical\n,\tO\nand\tO\nsteroids\tB-Chemical\nwere\tO\ngiven\tO\nas\tO\nimmunosuppressant\tO\n.\tO\n\nLamivudine\tB-Chemical\nwas\tO\nadded\tO\nbecause\tO\nof\tO\nde\tO\nnova\tO\nhepatitis\tB-Disease\nB\tI-Disease\ninfection\tI-Disease\nduring\tO\nher\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nThree\tO\nyr\tO\nafter\tO\ntransplantation\tO\nshe\tO\ndeveloped\tO\nrenal\tB-Disease\nFanconi\tI-Disease\nsyndrome\tI-Disease\nwith\tO\nsevere\tO\nmetabolic\tB-Disease\nacidosis\tI-Disease\n,\tO\nhypophosphatemia\tB-Disease\n,\tO\nglycosuria\tB-Disease\n,\tO\nand\tO\naminoaciduria\tB-Disease\n.\tO\n\nAlthough\tO\ntacrolimus\tB-Chemical\nwas\tO\nsuspected\tO\nto\tO\nbe\tO\nthe\tO\ncause\tO\nof\tO\nlate\tO\npost\tO\n-\tO\ntransplant\tO\nrenal\tO\nacidosis\tB-Disease\nand\tO\nwas\tO\nreplaced\tO\nby\tO\nsirolimus\tB-Chemical\n,\tO\nacidosis\tB-Disease\n,\tO\nand\tO\nelectrolyte\tO\nimbalance\tO\ngot\tO\nworse\tO\n.\tO\n\nProximal\tO\nmuscle\tB-Disease\nweakness\tI-Disease\nhas\tO\ndeveloped\tO\nduring\tO\nher\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nFanconi\tB-Disease\nsyndrome\tI-Disease\n,\tO\nas\tO\nwell\tO\nas\tO\nmyopathy\tB-Disease\n,\tO\nis\tO\nwell\tO\nrecognized\tO\nin\tO\npatients\tO\nwith\tO\nmitochondrial\tB-Disease\ndisorders\tI-Disease\nand\tO\ncaused\tO\nby\tO\ndepletion\tO\nof\tO\nmtDNA\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\nour\tO\npatient\tO\n'\tO\ns\tO\ntubular\tB-Disease\ndysfunction\tI-Disease\nand\tO\nmyopathy\tB-Disease\nmay\tO\nhave\tO\nresulted\tO\nfrom\tO\nmitochondrial\tB-Disease\ndysfunction\tI-Disease\nwhich\tO\nis\tO\ntriggered\tO\nby\tO\ntacrolimus\tB-Chemical\nand\tO\naugmented\tO\nby\tO\nlamivudine\tB-Chemical\n.\tO\n\nHigher\tO\noptical\tO\ndensity\tO\nof\tO\nan\tO\nantigen\tO\nassay\tO\npredicts\tO\nthrombosis\tB-Disease\nin\tO\npatients\tO\nwith\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\ncorrelate\tO\noptical\tO\ndensity\tO\nand\tO\npercent\tO\ninhibition\tO\nof\tO\na\tO\ntwo\tO\n-\tO\nstep\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n(\tO\nHIT\tB-Disease\n)\tO\nantigen\tO\nassay\tO\nwith\tO\nthrombosis\tB-Disease\n;\tO\nthe\tO\nassay\tO\nutilizes\tO\nreaction\tO\ninhibition\tO\ncharacteristics\tO\nof\tO\na\tO\nhigh\tO\nheparin\tB-Chemical\nconcentration\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nPatients\tO\nwith\tO\nmore\tO\nthan\tO\n50\tO\n%\tO\ndecrease\tO\nin\tO\nplatelet\tO\ncount\tO\nor\tO\nthrombocytopenia\tB-Disease\n(\tO\n<\tO\n150\tO\nx\tO\n10\tO\n(\tO\n9\tO\n)\tO\n/\tO\nL\tO\n)\tO\nafter\tO\nexposure\tO\nto\tO\nheparin\tB-Chemical\n,\tO\nwho\tO\nhad\tO\na\tO\npositive\tO\ntwo\tO\n-\tO\nstep\tO\nantigen\tO\nassay\tO\n[\tO\noptical\tO\ndensity\tO\n(\tO\nOD\tO\n)\tO\n>\tO\n0\tO\n.\tO\n4\tO\nand\tO\n>\tO\n50\tO\ninhibition\tO\nwith\tO\nhigh\tO\nconcentration\tO\nof\tO\nheparin\tB-Chemical\n]\tO\nwere\tO\nincluded\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nForty\tO\nof\tO\n94\tO\nHIT\tB-Disease\npatients\tO\nhad\tO\nthrombosis\tB-Disease\nat\tO\ndiagnosis\tO\n;\tO\n54\tO\n/\tO\n94\tO\nhad\tO\nisolated\tO\n-\tO\nHIT\tB-Disease\nwithout\tO\nthrombosis\tB-Disease\n.\tO\n\nEight\tO\nof\tO\nthe\tO\nisolated\tO\n-\tO\nHIT\tB-Disease\npatients\tO\ndeveloped\tO\nthrombosis\tB-Disease\nwithin\tO\nthe\tO\nnext\tO\n30\tO\nd\tO\n;\tO\nthus\tO\n,\tO\na\tO\ntotal\tO\nof\tO\n48\tO\npatients\tO\nhad\tO\nthrombosis\tB-Disease\nat\tO\nday\tO\n30\tO\n.\tO\n\nAt\tO\ndiagnosis\tO\nthere\tO\nwas\tO\nno\tO\nsignificant\tO\ndifference\tO\nin\tO\nOD\tO\nbetween\tO\nHIT\tB-Disease\npatients\tO\nwith\tO\nthrombosis\tB-Disease\nand\tO\nthose\tO\nwith\tO\nisolated\tO\n-\tO\nHIT\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nOD\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nin\tO\nall\tO\npatients\tO\nwith\tO\nthrombosis\tB-Disease\n(\tO\nn\tO\n=\tO\n48\tO\n,\tO\n1\tO\n.\tO\n34\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n89\tO\n)\tO\n,\tO\nincluding\tO\nisolated\tO\n-\tO\nHIT\tB-Disease\npatients\tO\nwho\tO\nlater\tO\ndeveloped\tO\nthrombosis\tB-Disease\nwithin\tO\n30\tO\nd\tO\n(\tO\nn\tO\n=\tO\n8\tO\n,\tO\n1\tO\n.\tO\n84\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n64\tO\n)\tO\nas\tO\ncompared\tO\nto\tO\nisolated\tO\n-\tO\nHIT\tB-Disease\npatients\tO\nwho\tO\ndid\tO\nnot\tO\ndevelop\tO\nthrombosis\tB-Disease\n(\tO\n0\tO\n.\tO\n96\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n75\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n011\tO\nand\tO\nP\tO\n=\tO\n0\tO\n.\tO\n008\tO\n)\tO\n.\tO\n\nThe\tO\nReceiver\tO\nOperative\tO\nCharacteristic\tO\nCurve\tO\nshowed\tO\nthat\tO\nOD\tO\n>\tO\n1\tO\n.\tO\n27\tO\nin\tO\nthe\tO\nisolated\tO\n-\tO\nHIT\tB-Disease\ngroup\tO\nhad\tO\na\tO\nsignificantly\tO\nhigher\tO\nchance\tO\nof\tO\ndeveloping\tO\nthrombosis\tB-Disease\nby\tO\nday\tO\n30\tO\n.\tO\n\nNone\tO\nof\tO\nthese\tO\ngroups\tO\nshowed\tO\nsignificant\tO\ndifference\tO\nin\tO\npercent\tO\ninhibition\tO\n.\tO\n\nMultivariate\tO\nanalysis\tO\nshowed\tO\na\tO\n2\tO\n.\tO\n8\tO\n-\tO\nfold\tO\nincreased\tO\nrisk\tO\nof\tO\nthrombosis\tB-Disease\nin\tO\nfemales\tO\n.\tO\n\nSimilarly\tO\n,\tO\nthrombotic\tB-Disease\nrisk\tO\nincreased\tO\nwith\tO\nage\tO\nand\tO\nOD\tO\nvalues\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nHigher\tO\nOD\tO\nis\tO\nassociated\tO\nwith\tO\nsignificant\tO\nrisk\tO\nof\tO\nsubsequent\tO\nthrombosis\tB-Disease\nin\tO\npatients\tO\nwith\tO\nisolated\tO\n-\tO\nHIT\tB-Disease\n;\tO\npercent\tO\ninhibition\tO\n,\tO\nhowever\tO\n,\tO\nwas\tO\nnot\tO\npredictive\tO\n.\tO\n\nThalidomide\tB-Chemical\nhas\tO\nlimited\tO\nsingle\tO\n-\tO\nagent\tO\nactivity\tO\nin\tO\nrelapsed\tO\nor\tO\nrefractory\tO\nindolent\tO\nnon\tB-Disease\n-\tI-Disease\nHodgkin\tI-Disease\nlymphomas\tI-Disease\n:\tO\na\tO\nphase\tO\nII\tO\ntrial\tO\nof\tO\nthe\tO\nCancer\tB-Disease\nand\tO\nLeukemia\tB-Disease\nGroup\tO\nB\tO\n.\tO\n\nThalidomide\tB-Chemical\nis\tO\nan\tO\nimmunomodulatory\tO\nagent\tO\nwith\tO\ndemonstrated\tO\nactivity\tO\nin\tO\nmultiple\tB-Disease\nmyeloma\tI-Disease\n,\tO\nmantle\tB-Disease\ncell\tI-Disease\nlymphoma\tI-Disease\nand\tO\nlymphoplasmacytic\tB-Disease\nlymphoma\tI-Disease\n.\tO\n\nIts\tO\nactivity\tO\nis\tO\nbelieved\tO\nto\tO\nbe\tO\ndue\tO\nmodulation\tO\nof\tO\nthe\tO\ntumour\tB-Disease\nmilieu\tO\n,\tO\nincluding\tO\ndownregulation\tO\nof\tO\nangiogenesis\tO\nand\tO\ninflammatory\tO\ncytokines\tO\n.\tO\n\nBetween\tO\nJuly\tO\n2001\tO\nand\tO\nApril\tO\n2004\tO\n,\tO\n24\tO\npatients\tO\nwith\tO\nrelapsed\tO\n/\tO\nrefractory\tO\nindolent\tO\nlymphomas\tB-Disease\nreceived\tO\nthalidomide\tB-Chemical\n200\tO\nmg\tO\ndaily\tO\nwith\tO\nescalation\tO\nby\tO\n100\tO\nmg\tO\ndaily\tO\nevery\tO\n1\tO\n-\tO\n2\tO\nweeks\tO\nas\tO\ntolerated\tO\n,\tO\nup\tO\nto\tO\na\tO\nmaximum\tO\nof\tO\n800\tO\nmg\tO\ndaily\tO\n.\tO\n\nPatients\tO\nhad\tO\nreceived\tO\na\tO\nmedian\tO\nof\tO\n2\tO\n(\tO\nrange\tO\n,\tO\n1\tO\n-\tO\n4\tO\n)\tO\nprior\tO\nregimens\tO\n.\tO\n\nOf\tO\n24\tO\nevaluable\tO\npatients\tO\n,\tO\ntwo\tO\nachieved\tO\na\tO\ncomplete\tO\nremission\tO\nand\tO\none\tO\nachieved\tO\na\tO\npartial\tO\nremission\tO\nfor\tO\nan\tO\noverall\tO\nresponse\tO\nrate\tO\nof\tO\n12\tO\n.\tO\n5\tO\n%\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n:\tO\n2\tO\n.\tO\n6\tO\n-\tO\n32\tO\n.\tO\n4\tO\n%\tO\n)\tO\n.\tO\n\nEleven\tO\npatients\tO\nprogressed\tO\nduring\tO\ntherapy\tO\n.\tO\n\nGrade\tO\n3\tO\n-\tO\n4\tO\nadverse\tO\neffects\tO\nincluded\tO\nmyelosuppression\tB-Disease\n,\tO\nfatigue\tB-Disease\n,\tO\nsomnolence\tB-Disease\n/\tO\ndepressed\tB-Disease\nmood\tI-Disease\n,\tO\nneuropathy\tB-Disease\nand\tO\ndyspnea\tB-Disease\n.\tO\n\nOf\tO\nconcern\tO\nwas\tO\nthe\tO\noccurrence\tO\nof\tO\nfour\tO\nthromboembolic\tB-Disease\nevents\tO\n.\tO\n\nOur\tO\nresults\tO\nfailed\tO\nto\tO\ndemonstrate\tO\nan\tO\nimportant\tO\nresponse\tO\nrate\tO\nto\tO\nsingle\tO\nagent\tO\nthalidomide\tB-Chemical\nin\tO\nindolent\tO\nlymphomas\tB-Disease\nand\tO\ncontrast\tO\nwith\tO\nthe\tO\nhigher\tO\nactivity\tO\nlevel\tO\nreported\tO\nwith\tO\nthe\tO\nsecond\tO\ngeneration\tO\nimmunomodulatory\tO\nagent\tO\n,\tO\nlenalidomide\tB-Chemical\n.\tO\n\nSex\tO\ndifferences\tO\nin\tO\nNMDA\tB-Chemical\nantagonist\tO\nenhancement\tO\nof\tO\nmorphine\tB-Chemical\nantihyperalgesia\tO\nin\tO\na\tO\ncapsaicin\tB-Chemical\nmodel\tO\nof\tO\npersistent\tO\npain\tB-Disease\n:\tO\ncomparisons\tO\nto\tO\ntwo\tO\nmodels\tO\nof\tO\nacute\tB-Disease\npain\tI-Disease\n.\tO\n\nIn\tO\nacute\tB-Disease\npain\tI-Disease\nmodels\tO\n,\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nantagonists\tO\nenhance\tO\nthe\tO\nantinociceptive\tO\neffects\tO\nof\tO\nmorphine\tB-Chemical\nto\tO\na\tO\ngreater\tO\nextent\tO\nin\tO\nmales\tO\nthan\tO\nfemales\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\ninvestigation\tO\nwas\tO\nto\tO\nextend\tO\nthese\tO\nfindings\tO\nto\tO\na\tO\npersistent\tO\npain\tB-Disease\nmodel\tO\nwhich\tO\ncould\tO\nbe\tO\ndistinguished\tO\nfrom\tO\nacute\tB-Disease\npain\tI-Disease\nmodels\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\nthe\tO\nnociceptive\tO\nfibers\tO\nactivated\tO\n,\tO\nneurochemical\tO\nsubstrates\tO\n,\tO\nand\tO\nduration\tO\nof\tO\nthe\tO\nnociceptive\tO\nstimulus\tO\n.\tO\n\nTo\tO\nthis\tO\nend\tO\n,\tO\npersistent\tO\nhyperalgesia\tB-Disease\nwas\tO\ninduced\tO\nby\tO\nadministration\tO\nof\tO\ncapsaicin\tB-Chemical\nin\tO\nthe\tO\ntail\tO\nof\tO\ngonadally\tO\nintact\tO\nF344\tO\nrats\tO\n,\tO\nfollowing\tO\nwhich\tO\nthe\tO\ntail\tO\nwas\tO\nimmersed\tO\nin\tO\na\tO\nmildly\tO\nnoxious\tO\nthermal\tO\nstimulus\tO\n,\tO\nand\tO\ntail\tO\n-\tO\nwithdrawal\tO\nlatencies\tO\nmeasured\tO\n.\tO\n\nFor\tO\ncomparison\tO\n,\tO\ntests\tO\nwere\tO\nconducted\tO\nin\tO\ntwo\tO\nacute\tB-Disease\npain\tI-Disease\nmodels\tO\n,\tO\nthe\tO\nhotplate\tO\nand\tO\nwarm\tO\nwater\tO\ntail\tO\n-\tO\nwithdrawal\tO\nprocedures\tO\n.\tO\n\nIn\tO\nmales\tO\n,\tO\nthe\tO\nnon\tO\n-\tO\ncompetitive\tO\nNMDA\tB-Chemical\nantagonist\tO\ndextromethorphan\tB-Chemical\nenhanced\tO\nthe\tO\nantihyperalgesic\tO\neffect\tO\nof\tO\nlow\tO\nto\tO\nmoderate\tO\ndoses\tO\nof\tO\nmorphine\tB-Chemical\nin\tO\na\tO\ndose\tO\n-\tO\nand\tO\ntime\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nAcross\tO\nthe\tO\ndoses\tO\nand\tO\npretreatment\tO\ntimes\tO\nexamined\tO\n,\tO\nenhancement\tO\nwas\tO\nnot\tO\nobserved\tO\nin\tO\nfemales\tO\n.\tO\n\nEnhancement\tO\nof\tO\nmorphine\tB-Chemical\nantinociception\tO\nby\tO\ndextromethorphan\tB-Chemical\nwas\tO\nseen\tO\nin\tO\nboth\tO\nmales\tO\nand\tO\nfemales\tO\nin\tO\nthe\tO\nacute\tB-Disease\npain\tI-Disease\nmodels\tO\n,\tO\nwith\tO\nthe\tO\nmagnitude\tO\nof\tO\nthis\tO\neffect\tO\nbeing\tO\ngreater\tO\nin\tO\nmales\tO\n.\tO\n\nThese\tO\nfindings\tO\ndemonstrate\tO\na\tO\nsexually\tO\n-\tO\ndimorphic\tO\ninteraction\tO\nbetween\tO\nNMDA\tB-Chemical\nantagonists\tO\nand\tO\nmorphine\tB-Chemical\nin\tO\na\tO\npersistent\tO\npain\tB-Disease\nmodel\tO\nthat\tO\ncan\tO\nbe\tO\ndistinguished\tO\nfrom\tO\nthose\tO\nobserved\tO\nin\tO\nacute\tB-Disease\npain\tI-Disease\nmodels\tO\n.\tO\n\nDevelopment\tO\nof\tO\nproteinuria\tB-Disease\nafter\tO\nswitch\tO\nto\tO\nsirolimus\tB-Chemical\n-\tO\nbased\tO\nimmunosuppression\tO\nin\tO\nlong\tO\n-\tO\nterm\tO\ncardiac\tO\ntransplant\tO\npatients\tO\n.\tO\n\nCalcineurin\tO\n-\tO\ninhibitor\tO\ntherapy\tO\ncan\tO\nlead\tO\nto\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\nin\tO\nheart\tO\ntransplantation\tO\npatients\tO\n.\tO\n\nThe\tO\nnovel\tO\nimmunosuppressive\tO\n(\tO\nIS\tO\n)\tO\ndrug\tO\nsirolmus\tB-Chemical\n(\tO\nSrl\tB-Chemical\n)\tO\nlacks\tO\nnephrotoxic\tB-Disease\neffects\tO\n;\tO\nhowever\tO\n,\tO\nproteinuria\tB-Disease\nassociated\tO\nwith\tO\nSrl\tB-Chemical\nhas\tO\nbeen\tO\nreported\tO\nfollowing\tO\nrenal\tO\ntransplantation\tO\n.\tO\n\nIn\tO\ncardiac\tO\ntransplantation\tO\n,\tO\nthe\tO\nincidence\tO\nof\tO\nproteinuria\tB-Disease\nassociated\tO\nwith\tO\nSrl\tB-Chemical\nis\tO\nunknown\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nlong\tO\n-\tO\nterm\tO\ncardiac\tO\ntransplant\tO\npatients\tO\nwere\tO\nswitched\tO\nfrom\tO\ncyclosporine\tB-Chemical\nto\tO\nSrl\tB-Chemical\n-\tO\nbased\tO\nIS\tO\n.\tO\n\nConcomitant\tO\nIS\tO\nconsisted\tO\nof\tO\nmycophenolate\tB-Chemical\nmofetil\tI-Chemical\n+\tO\n/\tO\n-\tO\nsteroids\tB-Chemical\n.\tO\n\nProteinuria\tO\nincreased\tO\nsignificantly\tO\nfrom\tO\na\tO\nmedian\tO\nof\tO\n0\tO\n.\tO\n13\tO\ng\tO\n/\tO\nday\tO\n(\tO\nrange\tO\n0\tO\n-\tO\n5\tO\n.\tO\n7\tO\n)\tO\npreswitch\tO\nto\tO\n0\tO\n.\tO\n23\tO\ng\tO\n/\tO\nday\tO\n(\tO\n0\tO\n-\tO\n9\tO\n.\tO\n88\tO\n)\tO\nat\tO\n24\tO\nmonths\tO\npostswitch\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n0024\tO\n)\tO\n.\tO\n\nBefore\tO\nthe\tO\nswitch\tO\n,\tO\n11\tO\n.\tO\n5\tO\n%\tO\nof\tO\npatients\tO\nhad\tO\nhigh\tO\n-\tO\ngrade\tO\nproteinuria\tB-Disease\n(\tO\n>\tO\n1\tO\n.\tO\n0\tO\ng\tO\n/\tO\nday\tO\n)\tO\n;\tO\nthis\tO\nincreased\tO\nto\tO\n22\tO\n.\tO\n9\tO\n%\tO\npostswitch\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n006\tO\n)\tO\n.\tO\n\nACE\tB-Chemical\ninhibitor\tI-Chemical\nand\tO\nangiotensin\tB-Chemical\n-\tI-Chemical\nreleasing\tI-Chemical\nblocker\tI-Chemical\n(\tO\nARB\tB-Chemical\n)\tO\ntherapy\tO\nreduced\tO\nproteinuria\tB-Disease\ndevelopment\tO\n.\tO\n\nPatients\tO\nwithout\tO\nproteinuria\tB-Disease\nhad\tO\nincreased\tO\nrenal\tO\nfunction\tO\n(\tO\nmedian\tO\n42\tO\n.\tO\n5\tO\nvs\tO\n.\tO\n64\tO\n.\tO\n1\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n25\tO\n)\tO\n,\tO\nwhereas\tO\npatients\tO\nwho\tO\ndeveloped\tO\nhigh\tO\n-\tO\ngrade\tO\nproteinuria\tB-Disease\nshowed\tO\ndecreased\tO\nrenal\tO\nfunction\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nfollow\tO\n-\tO\nup\tO\n(\tO\nmedian\tO\n39\tO\n.\tO\n6\tO\nvs\tO\n.\tO\n29\tO\n.\tO\n2\tO\n,\tO\np\tO\n=\tO\n0\tO\n.\tO\n125\tO\n)\tO\n.\tO\n\nThus\tO\n,\tO\nproteinuria\tB-Disease\nmay\tO\ndevelop\tO\nin\tO\ncardiac\tO\ntransplant\tO\npatients\tO\nafter\tO\nswitch\tO\nto\tO\nSrl\tB-Chemical\n,\tO\nwhich\tO\nmay\tO\nhave\tO\nan\tO\nadverse\tO\neffect\tO\non\tO\nrenal\tO\nfunction\tO\nin\tO\nthese\tO\npatients\tO\n.\tO\n\nSrl\tB-Chemical\nshould\tO\nbe\tO\nused\tO\nwith\tO\nACEi\tB-Chemical\n/\tO\nARB\tB-Chemical\ntherapy\tO\nand\tO\npatients\tO\nmonitored\tO\nfor\tO\nproteinuria\tB-Disease\nand\tO\nincreased\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nGinsenoside\tB-Chemical\nRg1\tI-Chemical\nrestores\tO\nthe\tO\nimpairment\tB-Disease\nof\tI-Disease\nlearning\tI-Disease\ninduced\tO\nby\tO\nchronic\tO\nmorphine\tB-Chemical\nadministration\tO\nin\tO\nrats\tO\n.\tO\n\nRg1\tB-Chemical\n,\tO\nas\tO\na\tO\nginsenoside\tB-Chemical\nextracted\tO\nfrom\tO\nPanax\tO\nginseng\tO\n,\tO\ncould\tO\nameliorate\tO\nspatial\tO\nlearning\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nthat\tO\nRg1\tB-Chemical\nmight\tO\nbe\tO\na\tO\nuseful\tO\nagent\tO\nfor\tO\nthe\tO\nprevention\tO\nand\tO\ntreatment\tO\nof\tO\nthe\tO\nadverse\tO\neffects\tO\nof\tO\nmorphine\tB-Chemical\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthe\tO\neffect\tO\nof\tO\nRg1\tB-Chemical\non\tO\nlearning\tB-Disease\nimpairment\tI-Disease\nby\tO\nchronic\tO\nmorphine\tB-Chemical\nadministration\tO\nand\tO\nthe\tO\nmechanism\tO\nresponsible\tO\nfor\tO\nthis\tO\neffect\tO\n.\tO\n\nMale\tO\nrats\tO\nwere\tO\nsubcutaneously\tO\ninjected\tO\nwith\tO\nmorphine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ntwice\tO\na\tO\nday\tO\nat\tO\n12\tO\nhour\tO\nintervals\tO\nfor\tO\n10\tO\ndays\tO\n,\tO\nand\tO\nRg1\tB-Chemical\n(\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\nintraperitoneally\tO\ninjected\tO\n2\tO\nhours\tO\nafter\tO\nthe\tO\nsecond\tO\ninjection\tO\nof\tO\nmorphine\tB-Chemical\nonce\tO\na\tO\nday\tO\nfor\tO\n10\tO\ndays\tO\n.\tO\n\nSpatial\tO\nlearning\tO\ncapacity\tO\nwas\tO\nassessed\tO\nin\tO\nthe\tO\nMorris\tO\nwater\tO\nmaze\tO\n.\tO\n\nThe\tO\nresults\tO\nshowed\tO\nthat\tO\nrats\tO\ntreated\tO\nwith\tO\nMorphine\tB-Chemical\n/\tO\nRg1\tB-Chemical\ndecreased\tO\nescape\tO\nlatency\tO\nand\tO\nincreased\tO\nthe\tO\ntime\tO\nspent\tO\nin\tO\nplatform\tO\nquadrant\tO\nand\tO\nentering\tO\nfrequency\tO\n.\tO\n\nBy\tO\nimplantation\tO\nof\tO\nelectrodes\tO\nand\tO\nelectrophysiological\tO\nrecording\tO\nin\tO\nvivo\tO\n,\tO\nthe\tO\nresults\tO\nshowed\tO\nthat\tO\nRg1\tB-Chemical\nrestored\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\npotentiation\tO\n(\tO\nLTP\tO\n)\tO\nimpaired\tO\nby\tO\nmorphine\tB-Chemical\nin\tO\nboth\tO\nfreely\tO\nmoving\tO\nand\tO\nanaesthetised\tO\nrats\tO\n.\tO\n\nThe\tO\nelectrophysiological\tO\nrecording\tO\nin\tO\nvitro\tO\nshowed\tO\nthat\tO\nRg1\tB-Chemical\nrestored\tO\nthe\tO\nLTP\tO\nin\tO\nslices\tO\nfrom\tO\nthe\tO\nrats\tO\ntreated\tO\nwith\tO\nmorphine\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nchanged\tO\nLTP\tO\nin\tO\nthe\tO\nslices\tO\nfrom\tO\nnormal\tO\nsaline\tO\n-\tO\nor\tO\nmorphine\tB-Chemical\n/\tO\nRg1\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n;\tO\nthis\tO\nrestoration\tO\ncould\tO\nbe\tO\ninhibited\tO\nby\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nreceptor\tO\nantagonist\tO\nMK801\tB-Chemical\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nRg1\tB-Chemical\nmay\tO\nsignificantly\tO\nimprove\tO\nthe\tO\nspatial\tO\nlearning\tO\ncapacity\tO\nimpaired\tO\nby\tO\nchonic\tO\nmorphine\tB-Chemical\nadministration\tO\nand\tO\nrestore\tO\nthe\tO\nmorphine\tB-Chemical\n-\tO\ninhibited\tO\nLTP\tO\n.\tO\n\nThis\tO\neffect\tO\nis\tO\nNMDA\tB-Chemical\nreceptor\tO\ndependent\tO\n.\tO\n\nSynthesis\tO\nof\tO\nN\tB-Chemical\n-\tI-Chemical\npyrimidinyl\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nphenoxyacetamides\tI-Chemical\nas\tO\nadenosine\tB-Chemical\nA2A\tO\nreceptor\tO\nantagonists\tO\n.\tO\n\nA\tO\nseries\tO\nof\tO\nN\tB-Chemical\n-\tI-Chemical\npyrimidinyl\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nphenoxyacetamide\tI-Chemical\nadenosine\tB-Chemical\nA\tO\n(\tO\n2A\tO\n)\tO\nantagonists\tO\nis\tO\ndescribed\tO\n.\tO\n\nSAR\tO\nstudies\tO\nled\tO\nto\tO\ncompound\tO\n14\tO\nwith\tO\nexcellent\tO\npotency\tO\n(\tO\nK\tO\n(\tO\ni\tO\n)\tO\n=\tO\n0\tO\n.\tO\n4\tO\nnM\tO\n)\tO\n,\tO\nselectivity\tO\n(\tO\nA\tO\n(\tO\n1\tO\n)\tO\n/\tO\nA\tO\n(\tO\n2A\tO\n)\tO\n>\tO\n100\tO\n)\tO\n,\tO\nand\tO\nefficacy\tO\n(\tO\nMED\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\nin\tO\nthe\tO\nrat\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nmodel\tO\nfor\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nEvidence\tO\nfor\tO\nan\tO\ninvolvement\tO\nof\tO\nD1\tO\nand\tO\nD2\tO\ndopamine\tB-Chemical\nreceptors\tO\nin\tO\nmediating\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\nsuggested\tO\nthat\tO\nrepeated\tO\nexposure\tO\nof\tO\nrats\tO\nto\tO\nthe\tO\ndrug\tO\nor\tO\nto\tO\nthe\tO\nexperimental\tO\nenvironment\tO\nis\tO\nnecessary\tO\nto\tO\nobserve\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nstimulation\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\nthe\tO\nrole\tO\nof\tO\nhabituation\tO\nto\tO\nthe\tO\nexperimental\tO\nenvironment\tO\non\tO\nthe\tO\nstimulant\tO\neffect\tO\nof\tO\nnicotine\tB-Chemical\nin\tO\nrats\tO\nwas\tO\nexamined\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthe\tO\nrole\tO\nof\tO\ndopamine\tB-Chemical\nreceptors\tO\nin\tO\nmediating\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nstimulation\tO\nwas\tO\ninvestigated\tO\nby\tO\nexamining\tO\nthe\tO\neffects\tO\nof\tO\nselective\tO\nD1\tO\nand\tO\nD2\tO\ndopamine\tB-Chemical\nreceptor\tO\nantagonists\tO\non\tO\nactivity\tO\ninduced\tO\nby\tO\nnicotine\tB-Chemical\n.\tO\n\nLocomotor\tO\nactivity\tO\nwas\tO\nassessed\tO\nin\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntested\tO\nin\tO\nphotocell\tO\ncages\tO\n.\tO\n\nNicotine\tB-Chemical\n(\tO\n1\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ncaused\tO\na\tO\nsignificant\tO\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nin\tO\nrats\tO\nthat\tO\nwere\tO\nhabituated\tO\nto\tO\nthe\tO\ntest\tO\nenvironment\tO\n,\tO\nbut\tO\nhad\tO\nonly\tO\na\tO\nweak\tO\nand\tO\ndelayed\tO\nstimulant\tO\naction\tO\nin\tO\nrats\tO\nthat\tO\nwere\tO\nunfamiliar\tO\nwith\tO\nthe\tO\ntest\tO\nenvironment\tO\n.\tO\n\nThe\tO\nstimulant\tO\naction\tO\nof\tO\nnicotine\tB-Chemical\nwas\tO\nblocked\tO\nby\tO\nthe\tO\ncentral\tO\nnicotinic\tO\nantagonist\tO\nmecamylamine\tB-Chemical\nbut\tO\nnot\tO\nby\tO\nthe\tO\nperipheral\tO\nnicotinic\tO\nblocker\tO\nhexamethonium\tB-Chemical\n,\tO\nindicating\tO\nthat\tO\nthe\tO\nresponse\tO\nis\tO\nprobably\tO\nmediated\tO\nby\tO\ncentral\tO\nnicotinic\tO\nreceptors\tO\n.\tO\n\nNicotine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nwas\tO\nblocked\tO\nby\tO\nthe\tO\nselective\tO\nD1\tO\nantagonist\tO\nSCH\tB-Chemical\n23390\tI-Chemical\n,\tO\nthe\tO\nselective\tO\nD2\tO\nantagonist\tO\nraclopride\tB-Chemical\nand\tO\nthe\tO\nD1\tO\n/\tO\nD2\tO\nantagonist\tO\nfluphenazine\tB-Chemical\n.\tO\n\nPretreatment\tO\nwith\tO\nthe\tO\nD2\tO\nagonist\tO\nPHNO\tB-Chemical\nenhanced\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n,\tO\nwhereas\tO\nthe\tO\nD1\tO\nagonist\tO\nSKF\tB-Chemical\n38393\tI-Chemical\nhad\tO\nno\tO\neffect\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nacute\tO\nnicotine\tB-Chemical\ninjection\tO\ninduces\tO\na\tO\npronounced\tO\nhyperactivity\tB-Disease\nin\tO\nrats\tO\nhabituated\tO\nto\tO\nthe\tO\ntest\tO\nenvironment\tO\n.\tO\n\nThe\tO\neffect\tO\nappears\tO\nto\tO\nbe\tO\nmediated\tO\nby\tO\ncentral\tO\nnicotine\tB-Chemical\nreceptors\tO\n,\tO\npossibly\tO\nlocated\tO\non\tO\ndopaminergic\tO\nneurons\tO\n,\tO\nand\tO\nalso\tO\nrequires\tO\nthe\tO\nactivation\tO\nof\tO\nboth\tO\nD1\tO\nand\tO\nD2\tO\ndopamine\tB-Chemical\nreceptors\tO\n.\tO\n\nCentral\tO\nretinal\tB-Disease\nvein\tI-Disease\nocclusion\tI-Disease\nassociated\tO\nwith\tO\nclomiphene\tB-Chemical\n-\tO\ninduced\tO\novulation\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\ncentral\tO\nretinal\tB-Disease\nvein\tI-Disease\nocclusion\tI-Disease\nassociated\tO\nwith\tO\nclomiphene\tB-Chemical\ncitrate\tI-Chemical\n(\tO\nCC\tB-Chemical\n)\tO\n.\tO\n\nDESIGN\tO\n:\tO\nCase\tO\nstudy\tO\n.\tO\n\nSETTING\tO\n:\tO\nOphthalmology\tO\nclinic\tO\nof\tO\nan\tO\nacademic\tO\nhospital\tO\n.\tO\n\nPATIENT\tO\n(\tO\nS\tO\n)\tO\n:\tO\nA\tO\n36\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nreferred\tO\nfrom\tO\nthe\tO\ninfertility\tB-Disease\nclinic\tO\nfor\tO\nblurred\tB-Disease\nvision\tI-Disease\n.\tO\n\nINTERVENTION\tO\n(\tO\nS\tO\n)\tO\n:\tO\nOphthalmic\tO\nexamination\tO\nafter\tO\nCC\tB-Chemical\ntherapy\tO\n.\tO\n\nMAIN\tO\nOUTCOME\tO\nMEASURE\tO\n(\tO\nS\tO\n)\tO\n:\tO\nCentral\tO\nretinal\tB-Disease\nvein\tI-Disease\nocclusion\tI-Disease\nafter\tO\novulation\tO\ninduction\tO\nwith\tO\nCC\tB-Chemical\n.\tO\n\nRESULT\tO\n(\tO\nS\tO\n)\tO\n:\tO\nA\tO\n36\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nChinese\tO\nwoman\tO\ndeveloped\tO\ncentral\tO\nretinal\tB-Disease\nvein\tI-Disease\nocclusion\tI-Disease\nafter\tO\neight\tO\ncourses\tO\nof\tO\nCC\tB-Chemical\n.\tO\n\nA\tO\nsearch\tO\nof\tO\nthe\tO\nliterature\tO\non\tO\nthe\tO\nthromboembolic\tB-Disease\ncomplications\tO\nof\tO\nCC\tB-Chemical\ndoes\tO\nnot\tO\ninclude\tO\nthis\tO\nsevere\tO\nophthalmic\tO\ncomplication\tO\n,\tO\nalthough\tO\nmild\tO\nvisual\tB-Disease\ndisturbance\tI-Disease\nafter\tO\nCC\tB-Chemical\nintake\tO\nis\tO\nnot\tO\nuncommon\tO\n.\tO\n\nCONCLUSION\tO\n(\tO\nS\tO\n)\tO\n:\tO\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nreported\tO\ncase\tO\nof\tO\ncentral\tO\nretinal\tB-Disease\nvein\tI-Disease\nocclusion\tI-Disease\nafter\tO\ntreatment\tO\nwith\tO\nCC\tB-Chemical\n.\tO\n\nExtra\tO\ncaution\tO\nis\tO\nwarranted\tO\nin\tO\ntreating\tO\ninfertility\tB-Disease\npatients\tO\nwith\tO\nCC\tB-Chemical\n,\tO\nand\tO\npatients\tO\nshould\tO\nbe\tO\nwell\tO\ninformed\tO\nof\tO\nthis\tO\nside\tO\neffect\tO\nbefore\tO\ncommencement\tO\nof\tO\ntherapy\tO\n.\tO\n\nAcute\tO\nbronchodilating\tO\neffects\tO\nof\tO\nipratropium\tB-Chemical\nbromide\tI-Chemical\nand\tO\ntheophylline\tB-Chemical\nin\tO\nchronic\tB-Disease\nobstructive\tI-Disease\npulmonary\tI-Disease\ndisease\tI-Disease\n.\tO\n\nThe\tO\nbronchodilator\tO\neffects\tO\nof\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nipratropium\tB-Chemical\nbromide\tI-Chemical\naerosol\tO\n(\tO\n36\tO\nmicrograms\tO\n)\tO\nand\tO\nshort\tO\n-\tO\nacting\tO\ntheophylline\tB-Chemical\ntablets\tO\n(\tO\ndose\tO\ntitrated\tO\nto\tO\nproduce\tO\nserum\tO\nlevels\tO\nof\tO\n10\tO\n-\tO\n20\tO\nmicrograms\tO\n/\tO\nmL\tO\n)\tO\nwere\tO\ncompared\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ncrossover\tO\nstudy\tO\nin\tO\n21\tO\npatients\tO\nwith\tO\nstable\tO\n,\tO\nchronic\tB-Disease\nobstructive\tI-Disease\npulmonary\tI-Disease\ndisease\tI-Disease\n.\tO\n\nMean\tO\npeak\tO\nforced\tO\nexpiratory\tO\nvolume\tO\nin\tO\n1\tO\nsecond\tO\n(\tO\nFEV1\tO\n)\tO\nincreases\tO\nover\tO\nbaseline\tO\nand\tO\nthe\tO\nproportion\tO\nof\tO\npatients\tO\nattaining\tO\nat\tO\nleast\tO\na\tO\n15\tO\n%\tO\nincrease\tO\nin\tO\nthe\tO\nFEV1\tO\n(\tO\nresponders\tO\n)\tO\nwere\tO\n31\tO\n%\tO\nand\tO\n90\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nfor\tO\nipratropium\tB-Chemical\nand\tO\n17\tO\n%\tO\nand\tO\n50\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nfor\tO\ntheophylline\tB-Chemical\n.\tO\n\nThe\tO\naverage\tO\nFEV1\tO\nincreases\tO\nduring\tO\nthe\tO\n6\tO\n-\tO\nhour\tO\nobservation\tO\nperiod\tO\nwere\tO\n18\tO\n%\tO\nfor\tO\nipratropium\tB-Chemical\nand\tO\n8\tO\n%\tO\nfor\tO\ntheophylline\tB-Chemical\n.\tO\n\nThe\tO\nmean\tO\nduration\tO\nof\tO\naction\tO\nwas\tO\n3\tO\n.\tO\n8\tO\nhours\tO\nwith\tO\nipratropium\tB-Chemical\nand\tO\n2\tO\n.\tO\n4\tO\nhours\tO\nwith\tO\ntheophylline\tB-Chemical\n.\tO\n\nWhile\tO\nside\tO\neffects\tO\nwere\tO\nrare\tO\n,\tO\nthose\tO\nexperienced\tO\nafter\tO\ntheophylline\tB-Chemical\nuse\tO\ndid\tO\ninvolve\tO\nthe\tO\ncardiovascular\tB-Disease\nand\tI-Disease\ngastrointestinal\tI-Disease\nsystems\tI-Disease\n.\tO\n\nThese\tO\nresults\tO\nshow\tO\nthat\tO\nipratropium\tB-Chemical\nis\tO\na\tO\nmore\tO\npotent\tO\nbronchodilator\tO\nthan\tO\noral\tO\ntheophylline\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nchronic\tB-Disease\nairflow\tI-Disease\nobstruction\tI-Disease\n.\tO\n\nMethamphetamine\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\nand\tO\nmicroglial\tO\nactivation\tO\nare\tO\nnot\tO\nmediated\tO\nby\tO\nfractalkine\tO\nreceptor\tO\nsignaling\tO\n.\tO\n\nMethamphetamine\tB-Chemical\n(\tO\nMETH\tB-Chemical\n)\tO\ndamages\tO\ndopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\nnerve\tO\nendings\tO\nby\tO\na\tO\nprocess\tO\nthat\tO\nhas\tO\nbeen\tO\nlinked\tO\nto\tO\nmicroglial\tO\nactivation\tO\nbut\tO\nthe\tO\nsignaling\tO\npathways\tO\nthat\tO\nmediate\tO\nthis\tO\nresponse\tO\nhave\tO\nnot\tO\nyet\tO\nbeen\tO\ndelineated\tO\n.\tO\n\nCardona\tO\net\tO\nal\tO\n.\tO\n\n[\tO\nNat\tO\n.\tO\nNeurosci\tO\n.\tO\n9\tO\n(\tO\n2006\tO\n)\tO\n,\tO\n917\tO\n]\tO\nrecently\tO\nidentified\tO\nthe\tO\nmicroglial\tO\n-\tO\nspecific\tO\nfractalkine\tO\nreceptor\tO\n(\tO\nCX3CR1\tO\n)\tO\nas\tO\nan\tO\nimportant\tO\nmediator\tO\nof\tO\nMPTP\tB-Chemical\n-\tO\ninduced\tO\nneurodegeneration\tB-Disease\nof\tO\nDA\tB-Chemical\nneurons\tO\n.\tO\n\nBecause\tO\nthe\tO\nCNS\tB-Disease\ndamage\tI-Disease\ncaused\tO\nby\tO\nMETH\tB-Chemical\nand\tO\nMPTP\tB-Chemical\nis\tO\nhighly\tO\nselective\tO\nfor\tO\nthe\tO\nDA\tB-Chemical\nneuronal\tO\nsystem\tO\nin\tO\nmouse\tO\nmodels\tO\nof\tO\nneurotoxicity\tB-Disease\n,\tO\nwe\tO\nhypothesized\tO\nthat\tO\nthe\tO\nCX3CR1\tO\nplays\tO\na\tO\nrole\tO\nin\tO\nMETH\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\nand\tO\nmicroglial\tO\nactivation\tO\n.\tO\n\nMice\tO\nin\tO\nwhich\tO\nthe\tO\nCX3CR1\tO\ngene\tO\nhas\tO\nbeen\tO\ndeleted\tO\nand\tO\nreplaced\tO\nwith\tO\na\tO\ncDNA\tO\nencoding\tO\nenhanced\tO\ngreen\tO\nfluorescent\tO\nprotein\tO\n(\tO\neGFP\tO\n)\tO\nwere\tO\ntreated\tO\nwith\tO\nMETH\tB-Chemical\nand\tO\nexamined\tO\nfor\tO\nstriatal\tO\nneurotoxicity\tB-Disease\n.\tO\n\nMETH\tB-Chemical\ndepleted\tO\nDA\tB-Chemical\n,\tO\ncaused\tO\nmicroglial\tO\nactivation\tO\n,\tO\nand\tO\nincreased\tO\nbody\tO\ntemperature\tO\nin\tO\nCX3CR1\tO\nknockout\tO\nmice\tO\nto\tO\nthe\tO\nsame\tO\nextent\tO\nand\tO\nover\tO\nthe\tO\nsame\tO\ntime\tO\ncourse\tO\nseen\tO\nin\tO\nwild\tO\n-\tO\ntype\tO\ncontrols\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nMETH\tB-Chemical\nin\tO\nCX3CR1\tO\nknockout\tO\nmice\tO\nwere\tO\nnot\tO\ngender\tO\n-\tO\ndependent\tO\nand\tO\ndid\tO\nnot\tO\nextend\tO\nbeyond\tO\nthe\tO\nstriatum\tO\n.\tO\n\nStriatal\tO\nmicroglia\tO\nexpressing\tO\neGFP\tO\nconstitutively\tO\nshow\tO\nmorphological\tO\nchanges\tO\nafter\tO\nMETH\tB-Chemical\nthat\tO\nare\tO\ncharacteristic\tO\nof\tO\nactivation\tO\n.\tO\n\nThis\tO\nresponse\tO\nwas\tO\nrestricted\tO\nto\tO\nthe\tO\nstriatum\tO\nand\tO\ncontrasted\tO\nsharply\tO\nwith\tO\nunresponsive\tO\neGFP\tO\n-\tO\nmicroglia\tO\nin\tO\nsurrounding\tO\nbrain\tO\nareas\tO\nthat\tO\nare\tO\nnot\tO\ndamaged\tO\nby\tO\nMETH\tB-Chemical\n.\tO\n\nWe\tO\nconclude\tO\nfrom\tO\nthese\tO\nstudies\tO\nthat\tO\nCX3CR1\tO\nsignaling\tO\ndoes\tO\nnot\tO\nmodulate\tO\nMETH\tB-Chemical\nneurotoxicity\tB-Disease\nor\tO\nmicroglial\tO\nactivation\tO\n.\tO\n\nFurthermore\tO\n,\tO\nit\tO\nappears\tO\nthat\tO\nstriatal\tO\n-\tO\nresident\tO\nmicroglia\tO\nrespond\tO\nto\tO\nMETH\tB-Chemical\nwith\tO\nan\tO\nactivation\tO\ncascade\tO\nand\tO\nthen\tO\nreturn\tO\nto\tO\na\tO\nsurveying\tO\nstate\tO\nwithout\tO\nundergoing\tO\napoptosis\tO\nor\tO\nmigration\tO\n.\tO\n\nNicotine\tB-Chemical\n-\tO\ninduced\tO\nnystagmus\tB-Disease\ncorrelates\tO\nwith\tO\nmidpontine\tO\nactivation\tO\n.\tO\n\nThe\tO\npathomechanism\tO\nof\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nnystagmus\tB-Disease\n(\tO\nNIN\tB-Disease\n)\tO\nis\tO\nunknown\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndelineate\tO\nbrain\tO\nstructures\tO\nthat\tO\nare\tO\ninvolved\tO\nin\tO\nNIN\tB-Disease\ngeneration\tO\n.\tO\n\nEight\tO\nhealthy\tO\nvolunteers\tO\ninhaled\tO\nnicotine\tB-Chemical\nin\tO\ndarkness\tO\nduring\tO\na\tO\nfunctional\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n(\tO\nfMRI\tO\n)\tO\nexperiment\tO\n;\tO\neye\tO\nmovements\tO\nwere\tO\nregistered\tO\nusing\tO\nvideo\tO\n-\tO\noculography\tO\n.\tO\n\nNIN\tB-Disease\ncorrelated\tO\nwith\tO\nblood\tO\noxygen\tB-Chemical\nlevel\tO\n-\tO\ndependent\tO\n(\tO\nBOLD\tO\n)\tO\nactivity\tO\nlevels\tO\nin\tO\na\tO\nmidpontine\tO\nsite\tO\nin\tO\nthe\tO\nposterior\tO\nbasis\tO\npontis\tO\n.\tO\n\nNIN\tB-Disease\n-\tO\ninduced\tO\nmidpontine\tO\nactivation\tO\nmay\tO\ncorrespond\tO\nto\tO\nactivation\tO\nof\tO\nthe\tO\ndorsomedial\tO\npontine\tO\nnuclei\tO\nand\tO\nthe\tO\nnucleus\tO\nreticularis\tO\ntegmenti\tO\npontis\tO\n,\tO\nstructures\tO\nknown\tO\nto\tO\nparticipate\tO\nin\tO\nthe\tO\ngeneration\tO\nof\tO\nmultidirectional\tO\nsaccades\tO\nand\tO\nsmooth\tO\npursuit\tO\neye\tO\nmovements\tO\n.\tO\n\nAcute\tO\neffects\tO\nof\tO\nN\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\npropylpentanoyl\tI-Chemical\n)\tI-Chemical\nurea\tI-Chemical\non\tO\nhippocampal\tO\namino\tB-Chemical\nacid\tI-Chemical\nneurotransmitters\tO\nin\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizure\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\naimed\tO\nto\tO\ninvestigate\tO\nthe\tO\nanticonvulsant\tO\nactivity\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\neffects\tO\non\tO\nthe\tO\nlevel\tO\nof\tO\nhippocampal\tO\namino\tB-Chemical\nacid\tI-Chemical\nneurotransmitters\tO\n(\tO\nglutamate\tB-Chemical\n,\tO\naspartate\tB-Chemical\n,\tO\nglycine\tB-Chemical\nand\tO\nGABA\tB-Chemical\n)\tO\nof\tO\nN\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\npropylpentanoyl\tI-Chemical\n)\tI-Chemical\nurea\tI-Chemical\n(\tO\nVPU\tB-Chemical\n)\tO\nin\tO\ncomparison\tO\nto\tO\nits\tO\nparent\tO\ncompound\tO\n,\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n(\tO\nVPA\tB-Chemical\n)\tO\n.\tO\n\nVPU\tB-Chemical\nwas\tO\nmore\tO\npotent\tO\nthan\tO\nVPA\tB-Chemical\n,\tO\nexhibiting\tO\nthe\tO\nmedian\tO\neffective\tO\ndose\tO\n(\tO\nED\tO\n(\tO\n50\tO\n)\tO\n)\tO\nof\tO\n49\tO\nmg\tO\n/\tO\nkg\tO\nin\tO\nprotecting\tO\nrats\tO\nagainst\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizure\tB-Disease\nwhereas\tO\nthe\tO\ncorresponding\tO\nvalue\tO\nfor\tO\nVPA\tB-Chemical\nwas\tO\n322\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nIn\tO\nvivo\tO\nmicrodialysis\tO\ndemonstrated\tO\nthat\tO\nan\tO\nintraperitoneal\tO\nadministration\tO\nof\tO\npilocarpine\tB-Chemical\ninduced\tO\na\tO\npronounced\tO\nincrement\tO\nof\tO\nhippocampal\tO\nglutamate\tB-Chemical\nand\tO\naspartate\tB-Chemical\nwhereas\tO\nno\tO\nsignificant\tO\nchange\tO\nwas\tO\nobserved\tO\non\tO\nthe\tO\nlevel\tO\nof\tO\nglycine\tB-Chemical\nand\tO\nGABA\tB-Chemical\n.\tO\n\nPretreatment\tO\nwith\tO\neither\tO\nVPU\tB-Chemical\n(\tO\n50\tO\nand\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nor\tO\nVPA\tB-Chemical\n(\tO\n300\tO\nand\tO\n600\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ncompletely\tO\nabolished\tO\npilocarpine\tB-Chemical\n-\tO\nevoked\tO\nincreases\tO\nin\tO\nextracellular\tO\nglutamate\tB-Chemical\nand\tO\naspartate\tB-Chemical\n.\tO\n\nIn\tO\naddition\tO\n,\tO\na\tO\nstatistically\tO\nsignificant\tO\nreduction\tO\nwas\tO\nalso\tO\nobserved\tO\non\tO\nthe\tO\nlevel\tO\nof\tO\nGABA\tB-Chemical\nand\tO\nglycine\tB-Chemical\nbut\tO\nless\tO\nthan\tO\na\tO\ndrastic\tO\nreduction\tO\nof\tO\nglutamate\tB-Chemical\nand\tO\naspartate\tB-Chemical\nlevel\tO\n.\tO\n\nBased\tO\non\tO\nthe\tO\nfinding\tO\nthat\tO\nVPU\tB-Chemical\nand\tO\nVPA\tB-Chemical\ncould\tO\nprotect\tO\nthe\tO\nanimals\tO\nagainst\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizure\tB-Disease\nit\tO\nis\tO\nsuggested\tO\nthat\tO\nthe\tO\nreduction\tO\nof\tO\ninhibitory\tO\namino\tB-Chemical\nacid\tI-Chemical\nneurotransmitters\tO\nwas\tO\ncomparatively\tO\nminor\tO\nand\tO\noffset\tO\nby\tO\na\tO\npronounced\tO\nreduction\tO\nof\tO\nglutamate\tB-Chemical\nand\tO\naspartate\tB-Chemical\n.\tO\n\nTherefore\tO\n,\tO\nlike\tO\nVPA\tB-Chemical\n,\tO\nthe\tO\nfinding\tO\nthat\tO\nVPU\tB-Chemical\ncould\tO\ndrastically\tO\nreduce\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nglutamate\tB-Chemical\nand\tO\naspartate\tB-Chemical\nshould\tO\naccount\tO\n,\tO\nat\tO\nleast\tO\npartly\tO\n,\tO\nfor\tO\nits\tO\nanticonvulsant\tO\nactivity\tO\nobserved\tO\nin\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nseizure\tB-Disease\nin\tO\nexperimental\tO\nanimals\tO\n.\tO\n\nSome\tO\nother\tO\nmechanism\tO\nthan\tO\nthose\tO\nbeing\tO\nreported\tO\nherein\tO\nshould\tO\nbe\tO\nfurther\tO\ninvestigated\tO\n.\tO\n\nProtective\tO\neffect\tO\nof\tO\nverapamil\tB-Chemical\non\tO\ngastric\tB-Disease\nhemorrhagic\tI-Disease\nulcers\tB-Disease\nin\tO\nsevere\tO\natherosclerotic\tB-Disease\nrats\tO\n.\tO\n\nStudies\tO\nconcerning\tO\nwith\tO\npathogenesis\tO\nof\tO\ngastric\tB-Disease\nhemorrhage\tI-Disease\nand\tO\nmucosal\tO\nulceration\tO\nproduced\tO\nin\tO\natherosclerotic\tB-Disease\nrats\tO\nare\tO\nlacking\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nis\tO\nto\tO\nexamine\tO\nthe\tO\nrole\tO\nof\tO\ngastric\tO\nacid\tO\nback\tO\n-\tO\ndiffusion\tO\n,\tO\nmast\tO\ncell\tO\nhistamine\tB-Chemical\nrelease\tO\n,\tO\nlipid\tO\nperoxide\tO\n(\tO\nLPO\tO\n)\tO\ngeneration\tO\nand\tO\nmucosal\tO\nmicrovascular\tO\npermeability\tO\nin\tO\nmodulating\tO\ngastric\tB-Disease\nhemorrhage\tI-Disease\nand\tO\nulcer\tB-Disease\nin\tO\nrats\tO\nwith\tO\natherosclerosis\tB-Disease\ninduced\tO\nby\tO\ncoadministration\tO\nof\tO\nvitamin\tB-Chemical\nD2\tI-Chemical\nand\tO\ncholesterol\tB-Chemical\n.\tO\n\nAdditionally\tO\n,\tO\nthe\tO\nprotective\tO\neffect\tO\nof\tO\nverapamil\tB-Chemical\non\tO\nthis\tO\nulcer\tB-Disease\nmodel\tO\nwas\tO\nevaluated\tO\n.\tO\n\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\nchallenged\tO\nintragastrically\tO\nonce\tO\ndaily\tO\nfor\tO\n9\tO\ndays\tO\nwith\tO\n1\tO\n.\tO\n0\tO\nml\tO\n/\tO\nkg\tO\nof\tO\ncorn\tO\noil\tO\ncontaining\tO\nvitamin\tB-Chemical\nD2\tI-Chemical\nand\tO\ncholesterol\tB-Chemical\nto\tO\ninduce\tO\natherosclerosis\tB-Disease\n.\tO\n\nControl\tO\nrats\tO\nreceived\tO\ncorn\tO\noil\tO\nonly\tO\n.\tO\n\nAfter\tO\ngastric\tO\nsurgery\tO\n,\tO\nrat\tO\nstomachs\tO\nwere\tO\nirrigated\tO\nfor\tO\n3\tO\nh\tO\nwith\tO\neither\tO\nsimulated\tO\ngastric\tO\njuice\tO\nor\tO\nnormal\tO\nsaline\tO\n.\tO\n\nGastric\tO\nacid\tO\nback\tO\n-\tO\ndiffusion\tO\n,\tO\nmucosal\tO\nLPO\tO\ngeneration\tO\n,\tO\nhistamine\tB-Chemical\nconcentration\tO\n,\tO\nmicrovascular\tO\npermeability\tO\n,\tO\nluminal\tB-Chemical\nhemoglobin\tO\ncontent\tO\nand\tO\nulcer\tB-Disease\nareas\tO\nwere\tO\ndetermined\tO\n.\tO\n\nElevated\tO\natherosclerotic\tB-Disease\nparameters\tO\n,\tO\nsuch\tO\nas\tO\nserum\tO\ncalcium\tB-Chemical\n,\tO\ntotal\tO\ncholesterol\tB-Chemical\nand\tO\nlow\tO\n-\tO\ndensity\tO\nlipoprotein\tO\nconcentration\tO\nwere\tO\nobtained\tO\nin\tO\natherosclerotic\tB-Disease\nrats\tO\n.\tO\n\nSevere\tO\ngastric\tO\nulcers\tB-Disease\naccompanied\tO\nwith\tO\nincreased\tO\nulcerogenic\tO\nfactors\tO\n,\tO\nincluding\tO\ngastric\tO\nacid\tO\nback\tO\n-\tO\ndiffusion\tO\n,\tO\nhistamine\tB-Chemical\nrelease\tO\n,\tO\nLPO\tO\ngeneration\tO\nand\tO\nluminal\tB-Chemical\nhemoglobin\tO\ncontent\tO\nwere\tO\nalso\tO\nobserved\tO\nin\tO\nthese\tO\nrats\tO\n.\tO\n\nMoreover\tO\n,\tO\na\tO\npositive\tO\ncorrelation\tO\nof\tO\nhistamine\tB-Chemical\nto\tO\ngastric\tB-Disease\nhemorrhage\tI-Disease\nand\tO\nto\tO\nulcer\tB-Disease\nwas\tO\nfound\tO\nin\tO\nthose\tO\natherosclerotic\tB-Disease\nrats\tO\n.\tO\n\nThis\tO\nhemorrhagic\tB-Disease\nulcer\tB-Disease\nand\tO\nvarious\tO\nulcerogenic\tO\nparameters\tO\nwere\tO\ndose\tO\n-\tO\ndependently\tO\nameliorated\tO\nby\tO\ndaily\tO\nintragastric\tO\nverapamil\tB-Chemical\n.\tO\n\nAtherosclerosis\tB-Disease\ncould\tO\nproduce\tO\ngastric\tB-Disease\nhemorrhagic\tI-Disease\nulcer\tB-Disease\nvia\tO\naggravation\tO\nof\tO\ngastric\tO\nacid\tO\nback\tO\n-\tO\ndiffusion\tO\n,\tO\nLPO\tO\ngeneration\tO\n,\tO\nhistamine\tB-Chemical\nrelease\tO\nand\tO\nmicrovascular\tO\npermeability\tO\nthat\tO\ncould\tO\nbe\tO\nameliorated\tO\nby\tO\nverapamil\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nLamivudine\tB-Chemical\nfor\tO\nthe\tO\nprevention\tO\nof\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\nreactivation\tO\nin\tO\nhepatitis\tB-Chemical\n-\tI-Chemical\nB\tI-Chemical\nsurface\tI-Chemical\nantigen\tI-Chemical\n(\tO\nHBSAG\tB-Chemical\n)\tO\nseropositive\tO\ncancer\tB-Disease\npatients\tO\nundergoing\tO\ncytotoxic\tO\nchemotherapy\tO\n.\tO\n\nHepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\n(\tO\nHBV\tO\n)\tO\nis\tO\none\tO\nof\tO\nthe\tO\nmajor\tO\ncauses\tO\nof\tO\nchronic\tO\nliver\tB-Disease\ndisease\tI-Disease\nworldwide\tO\n.\tO\n\nCancer\tB-Disease\npatients\tO\nwho\tO\nare\tO\nchronic\tO\ncarriers\tO\nof\tO\nHBV\tO\nhave\tO\na\tO\nhigher\tO\nhepatic\tB-Disease\ncomplication\tI-Disease\nrate\tO\nwhile\tO\nreceiving\tO\ncytotoxic\tO\nchemotherapy\tO\n(\tO\nCT\tO\n)\tO\nand\tO\nthis\tO\nhas\tO\nmainly\tO\nbeen\tO\nattributed\tO\nto\tO\nHBV\tO\nreactivation\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\ncancer\tB-Disease\npatients\tO\nwho\tO\nhave\tO\nsolid\tO\nand\tO\nhematological\tB-Disease\nmalignancies\tI-Disease\nwith\tO\nchronic\tO\nHBV\tB-Disease\ninfection\tI-Disease\nreceived\tO\nthe\tO\nantiviral\tO\nagent\tO\nlamivudine\tB-Chemical\nprior\tO\nand\tO\nduring\tO\nCT\tO\ncompared\tO\nwith\tO\nhistorical\tO\ncontrol\tO\ngroup\tO\nwho\tO\ndid\tO\nnot\tO\nreceive\tO\nlamivudine\tB-Chemical\n.\tO\n\nThe\tO\nobjectives\tO\nwere\tO\nto\tO\nassess\tO\nthe\tO\nefficacy\tO\nof\tO\nlamivudine\tB-Chemical\nin\tO\nreducing\tO\nthe\tO\nincidence\tO\nof\tO\nHBV\tO\nreactivation\tO\n,\tO\nand\tO\ndiminishing\tO\nmorbidity\tO\nand\tO\nmortality\tO\nduring\tO\nCT\tO\n.\tO\n\nTwo\tO\ngroups\tO\nwere\tO\ncompared\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nThe\tO\nprophylactic\tO\nlamivudin\tB-Chemical\ngroup\tO\nconsisted\tO\nof\tO\n37\tO\npatients\tO\nwho\tO\nreceived\tO\nprophylactic\tO\nlamivudine\tB-Chemical\ntreatment\tO\n.\tO\n\nThe\tO\nhistorical\tO\ncontrols\tO\nconsisted\tO\nof\tO\n50\tO\nconsecutive\tO\npatients\tO\nwho\tO\nunderwent\tO\nCT\tO\nwithout\tO\nprophylactic\tO\nlamivudine\tB-Chemical\n.\tO\n\nThey\tO\nwere\tO\nfollowed\tO\nup\tO\nduring\tO\nand\tO\nfor\tO\n8\tO\nweeks\tO\nafter\tO\nCT\tO\n.\tO\n\nThe\tO\noutcomes\tO\nwere\tO\ncompared\tO\nfor\tO\nboth\tO\ngroups\tO\n.\tO\n\nOf\tO\nour\tO\ncontrol\tO\ngroup\tO\n(\tO\nn\tO\n=\tO\n50\tO\n)\tO\n,\tO\n21\tO\npatients\tO\n(\tO\n42\tO\n%\tO\n)\tO\nwere\tO\nestablished\tO\nhepatitis\tB-Disease\n.\tO\n\nTwelve\tO\n(\tO\n24\tO\n%\tO\n)\tO\nof\tO\nthem\tO\nwere\tO\nevaluated\tO\nas\tO\nsevere\tO\nhepatitis\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\nprophylactic\tO\nlamivudine\tB-Chemical\ngroup\tO\nsevere\tO\nhepatitis\tB-Disease\nwere\tO\nobserved\tO\nonly\tO\nin\tO\n1\tO\npatient\tO\n(\tO\n2\tO\n.\tO\n7\tO\n%\tO\n)\tO\nof\tO\n37\tO\npatients\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n006\tO\n)\tO\n.\tO\n\nComparison\tO\nof\tO\nthe\tO\nmean\tO\nALT\tO\nvalues\tO\nrevealed\tO\nsignificantly\tO\nhigher\tO\nmean\tO\nalanine\tB-Chemical\naminotransferase\tO\n(\tO\nALT\tO\n)\tO\nvalues\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\nthan\tO\nthe\tO\nprophylactic\tO\nlamivudine\tB-Chemical\ngroup\tO\n;\tO\n154\tO\n:\tO\n64\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n32\tO\n)\tO\n.\tO\n\nOur\tO\nstudy\tO\nsuggests\tO\nthat\tO\nprophylactic\tO\nlamivudine\tB-Chemical\nsignificantly\tO\ndecreases\tO\nthe\tO\nincidence\tO\nof\tO\nHBV\tO\nreactivation\tO\nand\tO\noverall\tO\nmorbidity\tO\nin\tO\ncancer\tB-Disease\npatients\tO\nduring\tO\nand\tO\nafter\tO\nimmunosuppressive\tO\ntherapy\tO\n.\tO\n\nFurther\tO\nstudies\tO\nare\tO\nneeded\tO\nto\tO\ndetermine\tO\nthe\tO\nmost\tO\nappropriate\tO\nnucleoside\tB-Chemical\nor\tO\nnucleotide\tB-Chemical\nanalogue\tO\nfor\tO\nantiviral\tO\nprophylaxis\tO\nduring\tO\nCT\tO\nand\tO\nthe\tO\noptimal\tO\nduration\tO\nof\tO\nadministration\tO\nafter\tO\ncompletion\tO\nof\tO\nCT\tO\n.\tO\n\nRecovery\tO\nof\tO\ntacrolimus\tB-Chemical\n-\tO\nassociated\tO\nbrachial\tB-Disease\nneuritis\tI-Disease\nafter\tO\nconversion\tO\nto\tO\neverolimus\tB-Chemical\nin\tO\na\tO\npediatric\tO\nrenal\tO\ntransplant\tO\nrecipient\tO\n-\tO\n-\tO\ncase\tO\nreport\tO\nand\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\n.\tO\n\nTAC\tB-Chemical\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nbe\tO\na\tO\npotent\tO\nimmunosuppressive\tO\nagent\tO\nfor\tO\nsolid\tO\norgan\tO\ntransplantation\tO\nin\tO\npediatrics\tO\n.\tO\n\nNeurotoxicity\tB-Disease\nis\tO\na\tO\npotentially\tO\nserious\tO\ntoxic\tO\neffect\tO\n.\tO\n\nIt\tO\nis\tO\ncharacterized\tO\nby\tO\nencephalopathy\tB-Disease\n,\tO\nheadaches\tB-Disease\n,\tO\nseizures\tB-Disease\n,\tO\nor\tO\nneurological\tB-Disease\ndeficits\tI-Disease\n.\tO\n\nHere\tO\n,\tO\nwe\tO\ndescribe\tO\nan\tO\neight\tO\n-\tO\nand\tO\n-\tO\na\tO\n-\tO\nhalf\tO\n-\tO\nyr\tO\n-\tO\nold\tO\nmale\tO\nrenal\tO\ntransplant\tO\nrecipient\tO\nwith\tO\nright\tO\nBN\tO\n.\tO\n\nMRI\tO\ndemonstrated\tO\nhyperintense\tO\nT2\tO\nsignals\tO\nin\tO\nthe\tO\ncervical\tO\ncord\tO\nand\tO\nright\tO\nbrachial\tO\nplexus\tO\nroots\tO\nindicative\tO\nof\tO\nboth\tO\nmyelitis\tB-Disease\nand\tO\nright\tO\nbrachial\tB-Disease\nplexitis\tI-Disease\n.\tO\n\nSymptoms\tO\npersisted\tO\nfor\tO\nthree\tO\nmonths\tO\ndespite\tO\nTAC\tB-Chemical\ndose\tO\nreduction\tO\n,\tO\nadministration\tO\nof\tO\nIVIG\tO\nand\tO\nfour\tO\ndoses\tO\nof\tO\nmethylprednisolone\tB-Chemical\npulse\tO\ntherapy\tO\n.\tO\n\nImprovement\tO\nand\tO\neventually\tO\nfull\tO\nrecovery\tO\nonly\tO\noccurred\tO\nafter\tO\nTAC\tB-Chemical\nwas\tO\ncompletely\tO\ndiscontinued\tO\nand\tO\nsuccessfully\tO\nreplaced\tO\nby\tO\neverolimus\tB-Chemical\n.\tO\n\nOmitting\tO\nfentanyl\tB-Chemical\nreduces\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\n,\tO\nwithout\tO\nincreasing\tO\npain\tB-Disease\n,\tO\nafter\tO\nsevoflurane\tB-Chemical\nfor\tO\nday\tO\nsurgery\tO\n.\tO\n\nBACKGROUND\tO\nAND\tO\nOBJECTIVE\tO\n:\tO\nDespite\tO\nadvantages\tO\nof\tO\ninduction\tO\nand\tO\nmaintenance\tO\nof\tO\nanaesthesia\tO\nwith\tO\nsevoflurane\tB-Chemical\n,\tO\npostoperative\tB-Disease\nnausea\tI-Disease\nand\tI-Disease\nvomiting\tI-Disease\noccurs\tO\nfrequently\tO\n.\tO\n\nFentanyl\tB-Chemical\nis\tO\na\tO\ncommonly\tO\nused\tO\nsupplement\tO\nthat\tO\nmay\tO\ncontribute\tO\nto\tO\nthis\tO\n,\tO\nalthough\tO\nit\tO\nmay\tO\nalso\tO\nimprove\tO\nanalgesia\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThis\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\nexamined\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\npostoperative\tB-Disease\nnausea\tI-Disease\nand\tI-Disease\nvomiting\tI-Disease\nand\tO\npain\tB-Disease\nin\tO\nthe\tO\nfirst\tO\n24\tO\nh\tO\nafter\tO\nsevoflurane\tB-Chemical\nanaesthesia\tO\nin\tO\n216\tO\nadult\tO\nday\tO\nsurgery\tO\npatients\tO\n.\tO\n\nPatients\tO\nwere\tO\nrandomly\tO\nallocated\tO\nto\tO\neither\tO\nreceive\tO\nor\tO\nnot\tO\nreceive\tO\n1\tO\n1\tO\nfentanyl\tB-Chemical\n,\tO\nwhile\tO\na\tO\nthird\tO\ngroup\tO\nreceived\tO\ndexamethasone\tB-Chemical\nin\tO\naddition\tO\nto\tO\nfentanyl\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nOmission\tO\nof\tO\nfentanyl\tB-Chemical\ndid\tO\nnot\tO\nreduce\tO\nthe\tO\noverall\tO\nincidence\tO\nof\tO\npostoperative\tB-Disease\nnausea\tI-Disease\nand\tI-Disease\nvomiting\tI-Disease\n,\tO\nbut\tO\ndid\tO\nreduce\tO\nthe\tO\nincidence\tO\nof\tO\nvomiting\tB-Disease\nand\tO\n/\tO\nor\tO\nmoderate\tO\nto\tO\nsevere\tO\nnausea\tB-Disease\nprior\tO\nto\tO\ndischarge\tO\nfrom\tO\n20\tO\n%\tO\nand\tO\n17\tO\n%\tO\nwith\tO\nfentanyl\tB-Chemical\nand\tO\nfentanyl\tB-Chemical\n-\tO\ndexamethasone\tB-Chemical\n,\tO\nrespectively\tO\n,\tO\nto\tO\n5\tO\n%\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n013\tO\n)\tO\n.\tO\n\nAntiemetic\tO\nrequirements\tO\nwere\tO\nreduced\tO\nfrom\tO\n24\tO\n%\tO\nand\tO\n31\tO\n%\tO\nto\tO\n7\tO\n%\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n0012\tO\n)\tO\n.\tO\n\nDexamethasone\tB-Chemical\nhad\tO\nno\tO\nsignificant\tO\neffect\tO\non\tO\nthe\tO\nincidence\tO\nor\tO\nseverity\tO\nof\tO\npostoperative\tB-Disease\nnausea\tI-Disease\nand\tI-Disease\nvomiting\tI-Disease\n.\tO\n\nCombining\tO\nthe\tO\ntwo\tO\nfentanyl\tB-Chemical\ngroups\tO\nrevealed\tO\nfurther\tO\nsignificant\tO\nbenefits\tO\nfrom\tO\nthe\tO\navoidance\tO\nof\tO\nopioids\tO\n,\tO\nreducing\tO\npostoperative\tB-Disease\nnausea\tI-Disease\nand\tI-Disease\nvomiting\tI-Disease\nand\tO\nnausea\tB-Disease\nprior\tO\nto\tO\ndischarge\tO\nfrom\tO\n35\tO\n%\tO\nand\tO\n33\tO\n%\tO\nto\tO\n22\tO\n%\tO\nand\tO\n19\tO\n%\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n049\tO\nand\tO\nP\tO\n=\tO\n0\tO\n.\tO\n035\tO\n)\tO\n,\tO\nrespectively\tO\n,\tO\nwhile\tO\nnausea\tB-Disease\nin\tO\nthe\tO\nfirst\tO\n24\tO\nh\tO\nwas\tO\ndecreased\tO\nfrom\tO\n42\tO\n%\tO\nto\tO\n27\tO\n%\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n034\tO\n)\tO\n.\tO\n\nPain\tB-Disease\nseverity\tO\nand\tO\nanalgesic\tO\nrequirements\tO\nwere\tO\nunaffected\tO\nby\tO\nthe\tO\nomission\tO\nof\tO\nfentanyl\tB-Chemical\n.\tO\n\nFentanyl\tB-Chemical\ndid\tO\nreduce\tO\nminor\tO\nintraoperative\tO\nmovement\tO\nbut\tO\nhad\tO\nno\tO\nsevoflurane\tB-Chemical\n-\tO\nsparing\tO\neffect\tO\nand\tO\nincreased\tO\nrespiratory\tB-Disease\ndepression\tI-Disease\n,\tO\nhypotension\tB-Disease\nand\tO\nbradycardia\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nAs\tO\nfentanyl\tB-Chemical\nexacerbated\tO\npostoperative\tB-Disease\nnausea\tI-Disease\nand\tI-Disease\nvomiting\tI-Disease\nwithout\tO\nan\tO\nimprovement\tO\nin\tO\npostoperative\tB-Disease\npain\tI-Disease\nand\tO\nalso\tO\nhad\tO\nadverse\tO\ncardiorespiratory\tO\neffects\tO\n,\tO\nit\tO\nappears\tO\nto\tO\nbe\tO\nan\tO\nunnecessary\tO\nand\tO\npossibly\tO\ndetrimental\tO\nsupplement\tO\nto\tO\nsevoflurane\tB-Chemical\nin\tO\nday\tO\nsurgery\tO\n.\tO\n\nValvular\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\nin\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\ntreated\tO\nwith\tO\npergolide\tB-Chemical\n.\tO\n\nCourse\tO\nfollowing\tO\ntreatment\tO\nmodifications\tO\n.\tO\n\nValvular\tB-Disease\nheart\tI-Disease\nabnormalities\tI-Disease\nhave\tO\nbeen\tO\nreported\tO\nin\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\ntreated\tO\nwith\tO\npergolide\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nthese\tO\nabnormalities\tO\nvary\tO\nfrom\tO\nstudy\tO\nto\tO\nstudy\tO\nand\tO\ntheir\tO\ncourse\tO\nafter\tO\ndrug\tO\nwithdrawal\tO\nhas\tO\nnot\tO\nbeen\tO\nsystematically\tO\nassessed\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nTo\tO\nestimate\tO\nthe\tO\nfrequency\tO\nand\tO\nseverity\tO\nof\tO\nvalvular\tB-Disease\nheart\tI-Disease\nabnormality\tI-Disease\nand\tO\nits\tO\npossible\tO\nreversibility\tO\nafter\tO\ndrug\tO\nwithdrawal\tO\nin\tO\na\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nMETHODS\tO\n:\tO\nAll\tO\nPD\tB-Disease\npatients\tO\nin\tO\nthe\tO\nAmiens\tO\narea\tO\ntreated\tO\nwith\tO\npergolide\tB-Chemical\nwere\tO\ninvited\tO\nto\tO\nattend\tO\na\tO\ncardiologic\tO\nassessment\tO\nincluding\tO\ntransthoracic\tO\nechocardiography\tO\n.\tO\n\nThirty\tO\nPD\tB-Disease\npatients\tO\nparticipated\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nA\tO\nsecond\tO\nechocardiography\tO\nwas\tO\nperformed\tO\n(\tO\nmedian\tO\ninterval\tO\n:\tO\n13\tO\nmonths\tO\n)\tO\nafter\tO\npergolide\tB-Chemical\nwithdrawal\tO\n(\tO\nn\tO\n=\tO\n10\tO\npatients\tO\n)\tO\n.\tO\n\nControls\tO\nwere\tO\nage\tO\n-\tO\nand\tO\nsex\tO\n-\tO\nmatched\tO\nnon\tO\n-\tO\nPD\tB-Disease\npatients\tO\nreferred\tO\nto\tO\nthe\tO\ncardiology\tO\ndepartment\tO\n.\tO\n\nRESULTS\tO\n:\tO\nCompared\tO\nto\tO\ncontrols\tO\n,\tO\naortic\tB-Disease\nregurgitation\tI-Disease\n(\tO\nOR\tO\n:\tO\n3\tO\n.\tO\n1\tO\n;\tO\n95\tO\n%\tO\nIC\tO\n:\tO\n1\tO\n.\tO\n1\tO\n-\tO\n8\tO\n.\tO\n8\tO\n)\tO\nand\tO\nmitral\tB-Disease\nregurgitation\tI-Disease\n(\tO\nOR\tO\n:\tO\n10\tO\n.\tO\n7\tO\n;\tO\n95\tO\n%\tO\nIC\tO\n:\tO\n2\tO\n.\tO\n1\tO\n-\tO\n53\tO\n)\tO\nwere\tO\nmore\tO\nfrequent\tO\nin\tO\nPD\tB-Disease\npatients\tO\n(\tO\ntricuspid\tO\n:\tO\nNS\tO\n)\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\naffected\tO\nvalves\tO\n(\tO\nn\tO\n=\tO\n2\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\n)\tO\nand\tO\nthe\tO\nsum\tO\nof\tO\nregurgitation\tO\ngrades\tO\n(\tO\nn\tO\n=\tO\n2\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n09\tO\n)\tO\nwere\tO\nhigher\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n008\tO\nand\tO\np\tO\n=\tO\n0\tO\n.\tO\n006\tO\n,\tO\nrespectively\tO\n)\tO\nin\tO\nthe\tO\npergolide\tB-Chemical\ngroup\tO\n.\tO\n\nSeverity\tO\nof\tO\nregurgitation\tO\nwas\tO\nnot\tO\ncorrelated\tO\nwith\tO\npergolide\tB-Chemical\ncumulative\tO\ndose\tO\n.\tO\n\nA\tO\nrestrictive\tO\npattern\tO\nof\tO\nvalvular\tB-Disease\nregurgitation\tI-Disease\n,\tO\nsuggestive\tO\nof\tO\nthe\tO\nrole\tO\nof\tO\npergolide\tB-Chemical\n,\tO\nwas\tO\nobserved\tO\nin\tO\n12\tO\n/\tO\n30\tO\n(\tO\n40\tO\n%\tO\n)\tO\npatients\tO\nincluding\tO\ntwo\tO\nwith\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nPergolide\tB-Chemical\nwas\tO\ndiscontinued\tO\nin\tO\n10\tO\npatients\tO\nwith\tO\nvalvular\tB-Disease\nheart\tI-Disease\ndisease\tI-Disease\n,\tO\nresulting\tO\nin\tO\na\tO\nlower\tO\nregurgitation\tO\ngrade\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\nat\tO\nthe\tO\nsecond\tO\ntransthoracic\tO\nechocardiography\tO\nand\tO\nthe\tO\ntwo\tO\npatients\tO\nwith\tO\nheart\tB-Disease\nfailure\tI-Disease\nreturned\tO\nto\tO\nnearly\tO\nnormal\tO\nclinical\tO\nexamination\tO\n.\tO\n\nThis\tO\nstudy\tO\nsupports\tO\nthe\tO\nhigh\tO\nfrequency\tO\nof\tO\nrestrictive\tO\nvalve\tB-Disease\nregurgitation\tI-Disease\nin\tO\nPD\tB-Disease\npatients\tO\ntreated\tO\nwith\tO\npergolide\tB-Chemical\nand\tO\nreveals\tO\nthat\tO\na\tO\nsignificant\tO\nimprovement\tO\nis\tO\nusual\tO\nwhen\tO\nthe\tO\ntreatment\tO\nis\tO\nconverted\tO\nto\tO\nnon\tO\n-\tO\nergot\tO\ndopamine\tB-Chemical\nagonists\tO\n.\tO\n\nAdriamycin\tB-Chemical\n-\tO\ninduced\tO\nautophagic\tO\ncardiomyocyte\tO\ndeath\tB-Disease\nplays\tO\na\tO\npathogenic\tO\nrole\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nmechanisms\tO\nunderlying\tO\nheart\tB-Disease\nfailure\tI-Disease\ninduced\tO\nby\tO\nadriamycin\tB-Chemical\nare\tO\nvery\tO\ncomplicated\tO\nand\tO\nstill\tO\nunclear\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nwhether\tO\nautophagy\tO\nwas\tO\ninvolved\tO\nin\tO\nthe\tO\nprogression\tO\nof\tO\nheart\tB-Disease\nfailure\tI-Disease\ninduced\tO\nby\tO\nadriamycin\tB-Chemical\n,\tO\nso\tO\nthat\tO\nwe\tO\ncan\tO\ndevelop\tO\na\tO\nnovel\tO\ntreatment\tO\nstrategy\tO\nfor\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\n3\tB-Chemical\n-\tI-Chemical\nmethyladenine\tI-Chemical\n(\tO\n3MA\tB-Chemical\n)\tO\n,\tO\na\tO\nspecific\tO\ninhibitor\tO\non\tO\nautophagy\tO\nwas\tO\nused\tO\nin\tO\na\tO\nheart\tB-Disease\nfailure\tI-Disease\nmodel\tO\nof\tO\nrats\tO\ninduced\tO\nby\tO\nadriamycin\tB-Chemical\n.\tO\n\nNeonatal\tO\ncardiomyocytes\tO\nwere\tO\nisolated\tO\nfrom\tO\nSprague\tO\n-\tO\nDawley\tO\nrat\tO\nhearts\tO\nand\tO\nrandomly\tO\ndivided\tO\ninto\tO\ncontrols\tO\n,\tO\nan\tO\nadriamycin\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\n,\tO\nand\tO\na\tO\n3MA\tB-Chemical\nplus\tO\nadriamycin\tB-Chemical\n-\tO\ntreated\tO\ngroup\tO\n.\tO\n\nWe\tO\nthen\tO\nexamined\tO\nthe\tO\nmorphology\tO\n,\tO\nexpression\tO\nof\tO\nbeclin\tO\n1\tO\ngene\tO\n,\tO\nmitochondrial\tO\npermeability\tO\ntransition\tO\n(\tO\nMPT\tO\n)\tO\n,\tO\nand\tO\nNa\tO\n+\tO\n-\tO\nK\tB-Chemical\n+\tO\nATPase\tO\nactivity\tO\nin\tO\nvivo\tO\n.\tO\n\nWe\tO\nalso\tO\nassessed\tO\ncell\tO\nviability\tO\n,\tO\nmitochondrial\tO\nmembrane\tO\npotential\tO\nchanges\tO\nand\tO\ncounted\tO\nautophagic\tO\nvacuoles\tO\nin\tO\ncultured\tO\ncardiomyocytes\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nwe\tO\nanalyzed\tO\nthe\tO\nexpression\tO\nof\tO\nautophagy\tO\nassociated\tO\ngene\tO\n,\tO\nbeclin\tO\n1\tO\nusing\tO\nRT\tO\n-\tO\nPCR\tO\nand\tO\nWestern\tO\nblotting\tO\nin\tO\nan\tO\nanimal\tO\nmodel\tO\n.\tO\n\nRESULTS\tO\n:\tO\n3MA\tB-Chemical\nsignificantly\tO\nimproved\tO\ncardiac\tO\nfunction\tO\nand\tO\nreduced\tO\nmitochondrial\tO\ninjury\tO\n.\tO\n\nFurthermore\tO\n,\tO\nadriamycin\tB-Chemical\ninduced\tO\nthe\tO\nformation\tO\nof\tO\nautophagic\tO\nvacuoles\tO\n,\tO\nand\tO\n3MA\tB-Chemical\nstrongly\tO\ndownregulated\tO\nthe\tO\nexpression\tO\nof\tO\nbeclin\tO\n1\tO\nin\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\nfailing\tO\nheart\tO\nand\tO\ninhibited\tO\nthe\tO\nformation\tO\nof\tO\nautophagic\tO\nvacuoles\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nAutophagic\tO\ncardiomyocyte\tO\ndeath\tB-Disease\nplays\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nheart\tB-Disease\nfailure\tI-Disease\nin\tO\nrats\tO\ninduced\tO\nby\tO\nadriamycin\tB-Chemical\n.\tO\n\nMitochondrial\tO\ninjury\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\nprogression\tO\nof\tO\nheart\tB-Disease\nfailure\tI-Disease\ncaused\tO\nby\tO\nadriamycin\tB-Chemical\nvia\tO\nthe\tO\nautophagy\tO\npathway\tO\n.\tO\n\nmToR\tO\ninhibitors\tO\n-\tO\ninduced\tO\nproteinuria\tB-Disease\n:\tO\nmechanisms\tO\n,\tO\nsignificance\tO\n,\tO\nand\tO\nmanagement\tO\n.\tO\n\nMassive\tO\nurinary\tO\nprotein\tO\nexcretion\tO\nhas\tO\nbeen\tO\nobserved\tO\nafter\tO\nconversion\tO\nfrom\tO\ncalcineurin\tO\ninhibitors\tO\nto\tO\nmammalian\tO\ntarget\tO\nof\tO\nrapamycin\tB-Chemical\n(\tO\nmToR\tO\n)\tO\ninhibitors\tO\n,\tO\nespecially\tO\nsirolimus\tB-Chemical\n,\tO\nin\tO\nrenal\tO\ntransplant\tO\nrecipients\tO\nwith\tO\nchronic\tB-Disease\nallograft\tI-Disease\nnephropathy\tI-Disease\n.\tO\n\nBecause\tO\nproteinuria\tB-Disease\nis\tO\na\tO\nmajor\tO\npredictive\tO\nfactor\tO\nof\tO\npoor\tO\ntransplantation\tO\noutcome\tO\n,\tO\nmany\tO\nstudies\tO\nfocused\tO\non\tO\nthis\tO\nadverse\tO\nevent\tO\nduring\tO\nthe\tO\npast\tO\nyears\tO\n.\tO\n\nWhether\tO\nproteinuria\tB-Disease\nwas\tO\ndue\tO\nto\tO\nsirolimus\tB-Chemical\nor\tO\nonly\tO\na\tO\nconsequence\tO\nof\tO\ncalcineurin\tO\ninhibitors\tO\nwithdrawal\tO\nremained\tO\nunsolved\tO\nuntil\tO\nhigh\tO\nrange\tO\nproteinuria\tB-Disease\nhas\tO\nbeen\tO\nobserved\tO\nduring\tO\nsirolimus\tB-Chemical\ntherapy\tO\nin\tO\nislet\tO\ntransplantation\tO\nand\tO\nin\tO\npatients\tO\nwho\tO\nreceived\tO\nsirolimus\tB-Chemical\nde\tO\nnovo\tO\n.\tO\n\nPodocyte\tO\ninjury\tO\nand\tO\nfocal\tO\nsegmental\tO\nglomerulosclerosis\tB-Disease\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nmToR\tO\ninhibition\tO\nin\tO\nsome\tO\npatients\tO\n,\tO\nbut\tO\nthe\tO\npathways\tO\nunderlying\tO\nthese\tO\nlesions\tO\nremain\tO\nhypothetic\tO\n.\tO\n\nWe\tO\ndiscuss\tO\nherein\tO\nthe\tO\npossible\tO\nmechanisms\tO\nand\tO\nthe\tO\nsignificance\tO\nof\tO\nmToR\tO\nblockade\tO\n-\tO\ninduced\tO\nproteinuria\tB-Disease\n.\tO\n\nNeuropsychiatric\tO\nside\tO\neffects\tO\nafter\tO\nthe\tO\nuse\tO\nof\tO\nmefloquine\tB-Chemical\n.\tO\n\nThis\tO\nstudy\tO\ndescribes\tO\nneuropsychiatric\tO\nside\tO\neffects\tO\nin\tO\npatients\tO\nafter\tO\ntreatment\tO\nwith\tO\nmefloquine\tB-Chemical\n.\tO\n\nReactions\tO\nconsisted\tO\nmainly\tO\nof\tO\nseizures\tB-Disease\n,\tO\nacute\tO\npsychoses\tB-Disease\n,\tO\nanxiety\tB-Disease\nneurosis\tI-Disease\n,\tO\nand\tO\nmajor\tO\ndisturbances\tB-Disease\nof\tI-Disease\nsleep\tI-Disease\n-\tI-Disease\nwake\tI-Disease\nrhythm\tI-Disease\n.\tO\n\nSide\tO\neffects\tO\noccurred\tO\nafter\tO\nboth\tO\ntherapeutic\tO\nand\tO\nprophylactic\tO\nintake\tO\nand\tO\nwere\tO\ngraded\tO\nfrom\tO\nmoderate\tO\nto\tO\nsevere\tO\n.\tO\n\nIn\tO\na\tO\nrisk\tO\nanalysis\tO\nof\tO\nneuropsychiatric\tO\nside\tO\neffects\tO\nin\tO\nGermany\tO\n,\tO\nit\tO\nis\tO\nestimated\tO\nthat\tO\none\tO\nof\tO\n8\tO\n,\tO\n000\tO\nmefloquine\tB-Chemical\nusers\tO\nsuffers\tO\nfrom\tO\nsuch\tO\nreactions\tO\n.\tO\n\nThe\tO\nincidence\tO\ncalculation\tO\nrevealed\tO\nthat\tO\none\tO\nof\tO\n215\tO\ntherapeutic\tO\nusers\tO\nhad\tO\nreactions\tO\n,\tO\ncompared\tO\nwith\tO\none\tO\nof\tO\n13\tO\n,\tO\n000\tO\nin\tO\nthe\tO\nprophylaxis\tO\ngroup\tO\n,\tO\nmaking\tO\nthe\tO\nrisk\tO\nof\tO\nneuropsychiatric\tO\nreactions\tO\nafter\tO\nmefloquine\tB-Chemical\ntreatment\tO\n60\tO\ntimes\tO\nhigher\tO\nthan\tO\nafter\tO\nprophylaxis\tO\n.\tO\n\nTherefore\tO\n,\tO\ncertain\tO\nlimitations\tO\nfor\tO\nmalaria\tB-Disease\nprophylaxis\tO\nand\tO\ntreatment\tO\nwith\tO\nmefloquine\tB-Chemical\nare\tO\nrecommended\tO\n.\tO\n\nPrenatal\tO\nprotein\tO\ndeprivation\tO\nalters\tO\ndopamine\tB-Chemical\n-\tO\nmediated\tO\nbehaviors\tO\nand\tO\ndopaminergic\tO\nand\tO\nglutamatergic\tO\nreceptor\tO\nbinding\tO\n.\tO\n\nEpidemiological\tO\nevidence\tO\nindicates\tO\nthat\tO\nprenatal\tO\nnutritional\tO\ndeprivation\tO\nmay\tO\nincrease\tO\nthe\tO\nrisk\tO\nof\tO\nschizophrenia\tB-Disease\n.\tO\n\nThe\tO\ngoal\tO\nof\tO\nthese\tO\nstudies\tO\nwas\tO\nto\tO\nuse\tO\nan\tO\nanimal\tO\nmodel\tO\nto\tO\nexamine\tO\nthe\tO\neffects\tO\nof\tO\nprenatal\tO\nprotein\tO\ndeprivation\tO\non\tO\nbehaviors\tO\nand\tO\nreceptor\tO\nbinding\tO\nwith\tO\nrelevance\tO\nto\tO\nschizophrenia\tB-Disease\n.\tO\n\nWe\tO\nreport\tO\nthat\tO\nprenatally\tO\nprotein\tO\ndeprived\tO\n(\tO\nPD\tO\n)\tO\nfemale\tO\nrats\tO\nshowed\tO\nan\tO\nincreased\tO\nstereotypic\tO\nresponse\tO\nto\tO\napomorphine\tB-Chemical\nand\tO\nan\tO\nincreased\tO\nlocomotor\tO\nresponse\tO\nto\tO\namphetamine\tB-Chemical\nin\tO\nadulthood\tO\n.\tO\n\nThese\tO\ndifferences\tO\nwere\tO\nnot\tO\nobserved\tO\nduring\tO\npuberty\tO\n.\tO\n\nNo\tO\nchanges\tO\nin\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\ncatalepsy\tB-Disease\nor\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n-\tO\ninduced\tO\nlocomotion\tO\nwere\tO\nseen\tO\nfollowing\tO\nPD\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nPD\tO\nfemale\tO\nrats\tO\nshowed\tO\nincreased\tO\n(\tO\n3\tO\n)\tO\nH\tB-Chemical\n-\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\nbinding\tO\nin\tO\nthe\tO\nstriatum\tO\nand\tO\nhippocampus\tO\n,\tO\nbut\tO\nnot\tO\nin\tO\nthe\tO\ncortex\tO\n.\tO\n\nPD\tO\nfemale\tO\nrats\tO\nalso\tO\nshowed\tO\nincreased\tO\n(\tO\n3\tO\n)\tO\nH\tB-Chemical\n-\tO\nhaloperidol\tB-Chemical\nbinding\tO\nand\tO\ndecreased\tO\ndopamine\tB-Chemical\ntransporter\tO\nbinding\tO\nin\tO\nstriatum\tO\n.\tO\n\nNo\tO\nstatistically\tO\nsignificant\tO\nchanges\tO\nin\tO\nbehavior\tO\nor\tO\nreceptor\tO\nbinding\tO\nwere\tO\nfound\tO\nin\tO\nPD\tO\nmales\tO\nwith\tO\nthe\tO\nexception\tO\nof\tO\nincreased\tO\n(\tO\n3\tO\n)\tO\nH\tB-Chemical\n-\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\nbinding\tO\nin\tO\ncortex\tO\n.\tO\n\nThis\tO\nanimal\tO\nmodel\tO\nmay\tO\nbe\tO\nuseful\tO\nto\tO\nexplore\tO\nthe\tO\nmechanisms\tO\nby\tO\nwhich\tO\nprenatal\tO\nnutritional\tB-Disease\ndeficiency\tI-Disease\nenhances\tO\nrisk\tO\nfor\tO\nschizophrenia\tB-Disease\nin\tO\nhumans\tO\nand\tO\nmay\tO\nalso\tO\nhave\tO\nimplications\tO\nfor\tO\ndevelopmental\tO\nprocesses\tO\nleading\tO\nto\tO\ndifferential\tO\nsensitivity\tO\nto\tO\ndrugs\tO\nof\tO\nabuse\tO\n.\tO\n\nAdverse\tO\neffects\tO\nof\tO\ntopical\tO\npapaverine\tB-Chemical\non\tO\nauditory\tO\nnerve\tO\nfunction\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nPapaverine\tB-Chemical\nhydrochloride\tI-Chemical\nis\tO\na\tO\ndirect\tO\n-\tO\nacting\tO\nvasodilator\tO\nused\tO\nto\tO\nmanage\tO\nvasospasm\tB-Disease\nduring\tO\nvarious\tO\nneurosurgical\tO\noperations\tO\n.\tO\n\nTransient\tO\ncranial\tB-Disease\nnerve\tI-Disease\ndysfunction\tI-Disease\nhas\tO\nbeen\tO\ndescribed\tO\nin\tO\na\tO\nfew\tO\ncases\tO\nwith\tO\ntopical\tO\npapaverine\tB-Chemical\n.\tO\n\nThis\tO\nstudy\tO\nsupports\tO\nprevious\tO\nreports\tO\nand\tO\nprovides\tO\nneurophysiological\tO\nevidence\tO\nof\tO\nan\tO\nadverse\tO\neffect\tO\non\tO\nthe\tO\nauditory\tO\nnerve\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nconducted\tO\na\tO\nretrospective\tO\nreview\tO\nof\tO\n70\tO\nconsecutive\tO\nmicrovascular\tO\ndecompression\tO\noperations\tO\nand\tO\nstudied\tO\nthose\tO\npatients\tO\nwho\tO\nreceived\tO\ntopical\tO\npapaverine\tB-Chemical\nfor\tO\nvasospasm\tB-Disease\n.\tO\n\nTopical\tO\npapaverine\tB-Chemical\nwas\tO\nused\tO\nas\tO\na\tO\ndirect\tO\ntherapeutic\tO\naction\tO\nto\tO\nmanage\tO\nvasospasm\tB-Disease\nin\tO\na\tO\ntotal\tO\nof\tO\n11\tO\npatients\tO\n.\tO\n\nThe\tO\ntiming\tO\nof\tO\npapaverine\tB-Chemical\napplication\tO\nand\tO\nongoing\tO\noperative\tO\nevents\tO\nwas\tO\nreviewed\tO\nrelative\tO\nto\tO\nchanges\tO\nin\tO\nneurophysiological\tO\nrecordings\tO\n.\tO\n\nBrainstem\tO\nauditory\tO\nevoked\tO\npotentials\tO\n(\tO\nBAEPs\tO\n)\tO\nwere\tO\nroutinely\tO\nused\tO\nto\tO\nmonitor\tO\ncochlear\tO\nnerve\tO\nfunction\tO\nduring\tO\nthese\tO\noperations\tO\n.\tO\n\nFINDINGS\tO\n:\tO\nA\tO\ntemporal\tO\nrelationship\tO\nwas\tO\nfound\tO\nbetween\tO\ntopical\tO\npapaverine\tB-Chemical\nand\tO\nBAEP\tO\nchanges\tO\nleading\tO\nto\tO\ncomplete\tO\nwaveform\tO\nloss\tO\n.\tO\n\nThe\tO\naverage\tO\ntemporal\tO\ndelay\tO\nbetween\tO\npapaverine\tB-Chemical\nand\tO\nthe\tO\nonset\tO\nof\tO\nan\tO\nadverse\tO\nBAEP\tO\nchange\tO\nwas\tO\n5\tO\nmin\tO\n.\tO\n\nIn\tO\n10\tO\nof\tO\n11\tO\npatients\tO\n,\tO\nBAEP\tO\nwaves\tO\nII\tO\n/\tO\nIII\tO\n-\tO\nV\tO\ncompletely\tO\ndisappeared\tO\nwithin\tO\n2\tO\nto\tO\n25\tO\nmin\tO\nafter\tO\npapaverine\tB-Chemical\n.\tO\n\nEight\tO\nof\tO\nthese\tO\n10\tO\npatients\tO\nhad\tO\ncomplete\tO\nloss\tO\nof\tO\nBAEP\tO\nwaveforms\tO\nwithin\tO\n10\tO\nmin\tO\n.\tO\n\nOne\tO\npatient\tO\nshowed\tO\nno\tO\nrecovery\tO\nof\tO\nlater\tO\nwaves\tO\nand\tO\na\tO\ndelayed\tO\nprofound\tO\nsensorineural\tB-Disease\nhearing\tI-Disease\nloss\tI-Disease\n.\tO\n\nThe\tO\naverage\tO\nrecovery\tO\ntime\tO\nof\tO\nBAEP\tO\nwaveforms\tO\nto\tO\npre\tO\n-\tO\npapaverine\tB-Chemical\nbaseline\tO\nvalues\tO\nwas\tO\n39\tO\nmin\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nTopical\tO\npapaverine\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nvasospasm\tB-Disease\nwas\tO\nassociated\tO\nwith\tO\nthe\tO\nonset\tO\nof\tO\na\tO\ntransient\tO\ndisturbance\tO\nin\tO\nneurophysiological\tO\nfunction\tO\nof\tO\nthe\tO\nascending\tO\nauditory\tO\nbrainstem\tO\npathway\tO\n.\tO\n\nThe\tO\ncomplete\tO\ndisappearance\tO\nof\tO\nBAEP\tO\nwaveforms\tO\nwith\tO\na\tO\nconsistent\tO\ntemporal\tO\ndelay\tO\nsuggests\tO\na\tO\npossible\tO\nadverse\tB-Disease\neffect\tI-Disease\non\tI-Disease\nthe\tI-Disease\nproximal\tI-Disease\neighth\tI-Disease\nnerve\tI-Disease\n.\tO\n\nRecommendations\tO\nto\tO\navoid\tO\npotential\tO\ncranial\tB-Disease\nnerve\tI-Disease\ndeficits\tI-Disease\nfrom\tO\npapaverine\tB-Chemical\nare\tO\nprovided\tO\n.\tO\n\nSimvastatin\tB-Chemical\n-\tI-Chemical\nezetimibe\tI-Chemical\n-\tO\ninduced\tO\nhepatic\tB-Disease\nfailure\tI-Disease\nnecessitating\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nAbstract\tO\nSerum\tO\naminotransferase\tO\nelevations\tO\nare\tO\na\tO\ncommonly\tO\nknown\tO\nadverse\tO\neffect\tO\nof\tO\n3\tO\n-\tO\nhydroxy\tO\n-\tO\n3\tO\n-\tO\nmethylglutaryl\tO\ncoenzyme\tO\nA\tO\nreductase\tO\ninhibitor\tO\n(\tO\nstatin\tB-Chemical\n)\tO\ntherapy\tO\n.\tO\n\nHowever\tO\n,\tO\nhepatotoxic\tB-Disease\nevents\tO\nhave\tO\nnot\tO\nbeen\tO\nwidely\tO\npublished\tO\nwith\tO\nezetimibe\tB-Chemical\nor\tO\nthe\tO\ncombination\tO\nagent\tO\nsimvastatin\tB-Chemical\n-\tI-Chemical\nezetimibe\tI-Chemical\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n70\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nHispanic\tO\nwoman\tO\nwho\tO\ndeveloped\tO\nfulminant\tB-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\nnecessitating\tO\nliver\tO\ntransplantation\tO\n10\tO\nweeks\tO\nafter\tO\nconversion\tO\nfrom\tO\nsimvastatin\tB-Chemical\n40\tO\nmg\tO\n/\tO\nday\tO\nto\tO\nsimvastatin\tB-Chemical\n10\tI-Chemical\nmg\tI-Chemical\n-\tI-Chemical\nezetimibe\tI-Chemical\n40\tI-Chemical\nmg\tI-Chemical\n/\tO\nday\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nlipid\tO\npanel\tO\nhad\tO\nbeen\tO\nmaintained\tO\nwith\tO\nsimvastatin\tB-Chemical\nfor\tO\n18\tO\nmonths\tO\nbefore\tO\nthe\tO\nconversion\tO\nwithout\tO\nevidence\tO\nof\tO\nhepatotoxicity\tB-Disease\n.\tO\n\nA\tO\nroutine\tO\nlaboratory\tO\nwork\tO\n-\tO\nup\tO\n10\tO\nweeks\tO\nafter\tO\nconversion\tO\nrevealed\tO\nelevated\tO\nserum\tO\naminotransferase\tO\nlevels\tO\n.\tO\n\nSimvastatinezetimibe\tB-Chemical\nand\tO\nescitalopram\tB-Chemical\n(\tO\nwhich\tO\nshe\tO\nwas\tO\ntaking\tO\nfor\tO\ndepression\tB-Disease\n)\tO\nwere\tO\ndiscontinued\tO\n,\tO\nand\tO\nother\tO\npotential\tO\ncauses\tO\nof\tO\nhepatotoxicity\tB-Disease\nwere\tO\nexcluded\tO\n.\tO\n\nA\tO\nrepeat\tO\nwork\tO\n-\tO\nup\tO\nrevealed\tO\nfurther\tO\nelevations\tO\nin\tO\naminotransferase\tO\nlevels\tO\n,\tO\nand\tO\nliver\tO\nbiopsy\tO\nrevealed\tO\nevidence\tO\nof\tO\nmoderate\tO\n-\tO\nto\tO\n-\tO\nsevere\tO\ndrug\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nShe\tO\nunderwent\tO\nliver\tO\ntransplantation\tO\nwith\tO\nan\tO\nuneventful\tO\npostoperative\tO\ncourse\tO\n.\tO\n\nHer\tO\naminotransferase\tO\nlevels\tO\nreturned\tO\nto\tO\nnormal\tO\nby\tO\npostoperative\tO\nday\tO\n23\tO\n,\tO\nand\tO\nher\tO\n2\tO\n-\tO\nyear\tO\nfollow\tO\n-\tO\nup\tO\nshowed\tO\nno\tO\nadverse\tO\nevents\tO\n.\tO\n\nEzetimibe\tB-Chemical\nundergoes\tO\nextensive\tO\nglucuronidation\tO\nby\tO\nuridine\tB-Chemical\ndiphosphate\tI-Chemical\nglucoronosyltransferases\tO\n(\tO\nUGT\tO\n)\tO\nin\tO\nthe\tO\nintestine\tO\nand\tO\nliver\tO\nand\tO\nmay\tO\nhave\tO\ninhibited\tO\nthe\tO\nglucuronidation\tO\nof\tO\nsimvastatin\tB-Chemical\nhydroxy\tI-Chemical\nacid\tI-Chemical\n,\tO\nresulting\tO\nin\tO\nincreased\tO\nsimvastatin\tB-Chemical\nexposure\tO\nand\tO\nsubsequent\tO\nhepatotoxicity\tB-Disease\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\nsimvastatin\tB-Chemical\n-\tI-Chemical\nezetimibe\tI-Chemical\n-\tO\ninduced\tO\nliver\tB-Disease\nfailure\tI-Disease\nthat\tO\nresulted\tO\nin\tO\nliver\tO\ntransplantation\tO\n.\tO\n\nWe\tO\npostulate\tO\nthat\tO\nthe\tO\nmechanism\tO\nof\tO\nthe\tO\nsimvastatinezetimibe\tB-Chemical\n-\tO\ninduced\tO\nhepatotoxicity\tB-Disease\nis\tO\nthe\tO\nincreased\tO\nsimvastatin\tB-Chemical\nexposure\tO\nby\tO\nezetimibe\tB-Chemical\ninhibition\tO\nof\tO\nUGT\tO\nenzymes\tO\n.\tO\n\nClinicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\npotential\tO\nhepatotoxicity\tB-Disease\nwith\tO\nsimvastatin\tB-Chemical\n-\tI-Chemical\nezetimibe\tI-Chemical\nespecially\tO\nin\tO\nelderly\tO\npatients\tO\nand\tO\nshould\tO\ncarefully\tO\nmonitor\tO\nserum\tO\naminotransferase\tO\nlevels\tO\nwhen\tO\nstarting\tO\ntherapy\tO\nand\tO\ntitrating\tO\nthe\tO\ndosage\tO\n.\tO\n\nMassive\tO\nproteinuria\tB-Disease\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nafter\tO\noral\tO\nbisphosphonate\tB-Chemical\n(\tO\nalendronate\tB-Chemical\n)\tO\nadministration\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nfocal\tB-Disease\nsegmental\tI-Disease\nglomerulosclerosis\tI-Disease\n.\tO\n\nA\tO\n61\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nJapanese\tO\nman\tO\nwith\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\ndue\tO\nto\tO\nfocal\tB-Disease\nsegmental\tI-Disease\nglomerulosclerosis\tI-Disease\nwas\tO\ninitially\tO\nresponding\tO\nwell\tO\nto\tO\nsteroid\tB-Chemical\ntherapy\tO\n.\tO\n\nThe\tO\namount\tO\nof\tO\ndaily\tO\nurinary\tO\nprotein\tO\ndecreased\tO\nfrom\tO\n15\tO\n.\tO\n6\tO\nto\tO\n2\tO\n.\tO\n8\tO\ng\tO\n.\tO\n\nWithin\tO\n14\tO\ndays\tO\nof\tO\nthe\tO\noral\tO\nbisphosphonate\tB-Chemical\n(\tO\nalendronate\tB-Chemical\nsodium\tI-Chemical\n)\tO\nadministration\tO\n,\tO\nthe\tO\namount\tO\nof\tO\ndaily\tO\nurinary\tO\nprotein\tO\nincreased\tO\nrapidly\tO\nup\tO\nto\tO\n12\tO\n.\tO\n8\tO\ng\tO\nwith\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nAfter\tO\ndiscontinuing\tO\nthe\tO\noral\tO\nalendronate\tB-Chemical\n,\tO\nthe\tO\npatient\tO\nunderwent\tO\nsix\tO\ncycles\tO\nof\tO\nhemodialysis\tO\nand\tO\nfour\tO\ncycles\tO\nof\tO\nLDL\tO\napheresis\tO\n.\tO\n\nUrinary\tO\nvolume\tO\nand\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\nrecovered\tO\nto\tO\nthe\tO\nnormal\tO\nrange\tO\n,\tO\nwith\tO\nurinary\tO\nprotein\tO\ndisappearing\tO\ncompletely\tO\nwithin\tO\n40\tO\ndays\tO\n.\tO\n\nThis\tO\nreport\tO\ndemonstrates\tO\nthat\tO\nnot\tO\nonly\tO\nintravenous\tO\n,\tO\nbut\tO\nalso\tO\noral\tO\nbisphosphonates\tB-Chemical\ncan\tO\naggravate\tO\nproteinuria\tB-Disease\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nSerum\tO\n-\tO\nand\tO\nglucocorticoid\tO\n-\tO\ninducible\tO\nkinase\tO\n1\tO\nin\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nDoxorubicin\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\nleads\tO\nto\tO\nepithelial\tO\nsodium\tB-Chemical\nchannel\tO\n(\tO\nENaC\tO\n)\tO\n-\tO\ndependent\tO\nvolume\tB-Disease\nretention\tI-Disease\nand\tO\nrenal\tO\nfibrosis\tB-Disease\n.\tO\n\nThe\tO\naldosterone\tB-Chemical\n-\tO\nsensitive\tO\nserum\tO\n-\tO\nand\tO\nglucocorticoid\tO\n-\tO\ninducible\tO\nkinase\tO\nSGK1\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nparticipate\tO\nin\tO\nthe\tO\nstimulation\tO\nof\tO\nENaC\tO\nand\tO\nto\tO\nmediate\tO\nrenal\tO\nfibrosis\tB-Disease\nfollowing\tO\nmineralocorticoid\tO\nand\tO\nsalt\tO\nexcess\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nperformed\tO\nto\tO\nelucidate\tO\nthe\tO\nrole\tO\nof\tO\nSGK1\tO\nin\tO\nthe\tO\nvolume\tB-Disease\nretention\tI-Disease\nand\tO\nfibrosis\tB-Disease\nduring\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nTo\tO\nthis\tO\nend\tO\n,\tO\ndoxorubicin\tB-Chemical\n(\tO\n15\tO\nmug\tO\n/\tO\ng\tO\nbody\tO\nwt\tO\n)\tO\nwas\tO\ninjected\tO\nintravenously\tO\ninto\tO\ngene\tO\n-\tO\ntargeted\tO\nmice\tO\nlacking\tO\nSGK1\tO\n(\tO\nsgk1\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\n)\tO\nand\tO\ntheir\tO\nwild\tO\n-\tO\ntype\tO\nlittermates\tO\n(\tO\nsgk1\tO\n(\tO\n+\tO\n/\tO\n+\tO\n)\tO\n)\tO\n.\tO\n\nDoxorubicin\tB-Chemical\ntreatment\tO\nresulted\tO\nin\tO\nheavy\tO\nproteinuria\tB-Disease\n(\tO\n>\tO\n100\tO\nmg\tO\nprotein\tO\n/\tO\nmg\tO\ncrea\tO\n)\tO\nin\tO\n15\tO\n/\tO\n44\tO\nof\tO\nsgk1\tO\n(\tO\n+\tO\n/\tO\n+\tO\n)\tO\nand\tO\n15\tO\n/\tO\n44\tO\nof\tO\nsgk1\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nleading\tO\nto\tO\nsevere\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\nwith\tO\nascites\tB-Disease\n,\tO\nlipidemia\tB-Disease\n,\tO\nand\tO\nhypoalbuminemia\tB-Disease\nin\tO\nboth\tO\ngenotypes\tO\n.\tO\n\nPlasma\tO\naldosterone\tB-Chemical\nlevels\tO\nincreased\tO\nin\tO\nnephrotic\tB-Disease\nmice\tO\nof\tO\nboth\tO\ngenotypes\tO\nand\tO\nwas\tO\nfollowed\tO\nby\tO\nincreased\tO\nSGK1\tO\nprotein\tO\nexpression\tO\nin\tO\nsgk1\tO\n(\tO\n+\tO\n/\tO\n+\tO\n)\tO\nmice\tO\n.\tO\n\nUrinary\tO\nsodium\tB-Chemical\nexcretion\tO\nreached\tO\nsignficantly\tO\nlower\tO\nvalues\tO\nin\tO\nsgk1\tO\n(\tO\n+\tO\n/\tO\n+\tO\n)\tO\nmice\tO\n(\tO\n15\tO\n+\tO\n/\tO\n-\tO\n5\tO\nmumol\tO\n/\tO\nmg\tO\ncrea\tO\n)\tO\nthan\tO\nin\tO\nsgk1\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n(\tO\n35\tO\n+\tO\n/\tO\n-\tO\n5\tO\nmumol\tO\n/\tO\nmg\tO\ncrea\tO\n)\tO\nand\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nsignificantly\tO\nhigher\tO\nbody\tO\nweight\tB-Disease\ngain\tI-Disease\nin\tO\nsgk1\tO\n(\tO\n+\tO\n/\tO\n+\tO\n)\tO\ncompared\tO\nwith\tO\nsgk1\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n(\tO\n+\tO\n6\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n7\tO\nvs\tO\n.\tO\n+\tO\n4\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n8\tO\ng\tO\n)\tO\n.\tO\n\nDuring\tO\nthe\tO\ncourse\tO\nof\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n,\tO\nserum\tO\nurea\tB-Chemical\nconcentrations\tO\nincreased\tO\nsignificantly\tO\nfaster\tO\nin\tO\nsgk1\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\nthan\tO\nin\tO\nsgk1\tO\n(\tO\n+\tO\n/\tO\n+\tO\n)\tO\nmice\tO\nleading\tO\nto\tO\nuremia\tB-Disease\nand\tO\na\tO\nreduced\tO\nmedian\tO\nsurvival\tO\nin\tO\nsgk1\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n(\tO\n29\tO\nvs\tO\n.\tO\n40\tO\ndays\tO\nin\tO\nsgk1\tO\n(\tO\n+\tO\n/\tO\n+\tO\n)\tO\nmice\tO\n)\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\ngene\tO\n-\tO\ntargeted\tO\nmice\tO\nlacking\tO\nSGK1\tO\nshowed\tO\nblunted\tO\nvolume\tB-Disease\nretention\tI-Disease\n,\tO\nyet\tO\nwere\tO\nnot\tO\nprotected\tO\nagainst\tO\nrenal\tO\nfibrosis\tB-Disease\nduring\tO\nexperimental\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nSevere\tO\nthrombocytopenia\tB-Disease\nand\tO\nhaemolytic\tB-Disease\nanaemia\tI-Disease\nassociated\tO\nwith\tO\nciprofloxacin\tB-Chemical\n:\tO\na\tO\ncase\tO\nreport\tO\nwith\tO\nfatal\tO\noutcome\tO\n.\tO\n\nHaematological\tO\nadverse\tO\nreactions\tO\nassociated\tO\nwith\tO\nfatal\tO\noutcome\tO\nare\tO\nrare\tO\nduring\tO\ntreatment\tO\nwith\tO\nciprofloxacin\tB-Chemical\n.\tO\n\nA\tO\n30\tO\n-\tO\nyear\tO\nold\tO\nCaucasian\tO\nman\tO\nreported\tO\nwith\tO\nabdominal\tB-Disease\npain\tI-Disease\nand\tO\njaundice\tB-Disease\nafter\tO\n3\tO\n-\tO\nday\tO\nadministration\tO\nof\tO\noral\tO\nciprofloxacin\tB-Chemical\nfor\tO\na\tO\nsuspect\tO\nof\tO\nurinary\tB-Disease\ntract\tI-Disease\ninfection\tI-Disease\n.\tO\n\nClinical\tO\nevaluations\tO\nsuggested\tO\nan\tO\ninitial\tO\ndiagnosis\tO\nof\tO\nsevere\tO\nthrombocytopenia\tB-Disease\nand\tO\nhaemolysis\tB-Disease\n.\tO\n\nThe\tO\npatient\tO\nprogressively\tO\ndeveloped\tO\npetechiae\tB-Disease\nand\tO\npurpura\tB-Disease\non\tO\nthorax\tO\nand\tO\nlower\tO\nlimbs\tO\n.\tO\n\nDespite\tO\npharmacological\tO\nand\tO\nsupportive\tO\ninterventions\tO\n,\tO\nlaboratory\tO\nparameters\tO\nworsened\tO\nand\tO\nthe\tO\npatient\tO\ndied\tO\n17\tO\nhours\tO\nafter\tO\nadmission\tO\n.\tO\n\nAn\tO\naccurate\tO\nautopsy\tO\nrevealed\tO\nmost\tO\norgans\tO\nwith\tO\ndiffuse\tO\npetechial\tO\nhaemorrhages\tB-Disease\n.\tO\n\nNo\tO\nsigns\tO\nof\tO\nbone\tB-Disease\nmarrow\tI-Disease\ndepression\tI-Disease\nwere\tO\nfound\tO\n.\tO\n\nNo\tO\nthrombi\tB-Disease\nor\tO\nsigns\tO\nof\tO\nmicroangiopathies\tB-Disease\nwere\tO\nobserved\tO\nin\tO\narterial\tO\nvessels\tO\n.\tO\n\nBlood\tO\nand\tO\nurine\tO\ncultures\tO\ndid\tO\nnot\tO\nshow\tO\nany\tO\nbacterial\tO\ngrowth\tO\n.\tO\n\nThis\tO\ncase\tO\nreport\tO\nshows\tO\nthat\tO\nciprofloxacin\tB-Chemical\nmay\tO\nprecipitate\tO\nlife\tO\n-\tO\nthreatening\tO\nthrombocytopenia\tB-Disease\nand\tO\nhaemolytic\tB-Disease\nanaemia\tI-Disease\n,\tO\neven\tO\nin\tO\nthe\tO\nearly\tO\nphases\tO\nof\tO\ntreatment\tO\nand\tO\nwithout\tO\napparent\tO\nprevious\tO\nexposures\tO\n.\tO\n\nAlpha\tB-Chemical\n-\tI-Chemical\nlipoic\tI-Chemical\nacid\tI-Chemical\nprevents\tO\nmitochondrial\tB-Disease\ndamage\tI-Disease\nand\tO\nneurotoxicity\tB-Disease\nin\tO\nexperimental\tO\nchemotherapy\tO\nneuropathy\tB-Disease\n.\tO\n\nThe\tO\nstudy\tO\ninvestigates\tO\nif\tO\nalpha\tB-Chemical\n-\tI-Chemical\nlipoic\tI-Chemical\nacid\tI-Chemical\nis\tO\nneuroprotective\tO\nagainst\tO\nchemotherapy\tO\ninduced\tO\nneurotoxicity\tB-Disease\n,\tO\nif\tO\nmitochondrial\tB-Disease\ndamage\tI-Disease\nplays\tO\na\tO\ncritical\tO\nrole\tO\nin\tO\ntoxic\tB-Disease\nneurodegenerative\tI-Disease\ncascade\tI-Disease\n,\tO\nand\tO\nif\tO\nneuroprotective\tO\neffects\tO\nof\tO\nalpha\tB-Chemical\n-\tI-Chemical\nlipoic\tI-Chemical\nacid\tI-Chemical\ndepend\tO\non\tO\nmitochondria\tO\nprotection\tO\n.\tO\n\nWe\tO\nused\tO\nan\tO\nin\tO\nvitro\tO\nmodel\tO\nof\tO\nchemotherapy\tO\ninduced\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\nthat\tO\nclosely\tO\nmimic\tO\nthe\tO\nin\tO\nvivo\tO\ncondition\tO\nby\tO\nexposing\tO\nprimary\tO\ncultures\tO\nof\tO\ndorsal\tO\nroot\tO\nganglion\tO\n(\tO\nDRG\tO\n)\tO\nsensory\tO\nneurons\tO\nto\tO\npaclitaxel\tB-Chemical\nand\tO\ncisplatin\tB-Chemical\n,\tO\ntwo\tO\nwidely\tO\nused\tO\nand\tO\nhighly\tO\neffective\tO\nchemotherapeutic\tO\ndrugs\tO\n.\tO\n\nThis\tO\napproach\tO\nallowed\tO\ninvestigating\tO\nthe\tO\nefficacy\tO\nof\tO\nalpha\tB-Chemical\n-\tI-Chemical\nlipoic\tI-Chemical\nacid\tI-Chemical\nin\tO\npreventing\tO\naxonal\tB-Disease\ndamage\tI-Disease\nand\tO\napoptosis\tO\nand\tO\nthe\tO\nfunction\tO\nand\tO\nultrastructural\tO\nmorphology\tO\nof\tO\nmitochondria\tO\nafter\tO\nexposure\tO\nto\tO\ntoxic\tO\nagents\tO\nand\tO\nalpha\tB-Chemical\n-\tI-Chemical\nlipoic\tI-Chemical\nacid\tI-Chemical\n.\tO\n\nOur\tO\nresults\tO\ndemonstrate\tO\nthat\tO\nboth\tO\ncisplatin\tB-Chemical\nand\tO\npaclitaxel\tB-Chemical\ncause\tO\nearly\tO\nmitochondrial\tB-Disease\nimpairment\tI-Disease\nwith\tO\nloss\tO\nof\tO\nmembrane\tO\npotential\tO\nand\tO\ninduction\tO\nof\tO\nautophagic\tO\nvacuoles\tO\nin\tO\nneurons\tO\n.\tO\n\nAlpha\tB-Chemical\n-\tI-Chemical\nlipoic\tI-Chemical\nacid\tI-Chemical\nexerts\tO\nneuroprotective\tO\neffects\tO\nagainst\tO\nchemotherapy\tO\ninduced\tO\nneurotoxicity\tB-Disease\nin\tO\nsensory\tO\nneurons\tO\n:\tO\nit\tO\nrescues\tO\nthe\tO\nmitochondrial\tB-Disease\ntoxicity\tI-Disease\nand\tO\ninduces\tO\nthe\tO\nexpression\tO\nof\tO\nfrataxin\tO\n,\tO\nan\tO\nessential\tO\nmitochondrial\tO\nprotein\tO\nwith\tO\nanti\tO\n-\tO\noxidant\tO\nand\tO\nchaperone\tO\nproperties\tO\n.\tO\n\nIn\tO\nconclusion\tO\nmitochondrial\tB-Disease\ntoxicity\tI-Disease\nis\tO\nan\tO\nearly\tO\ncommon\tO\nevent\tO\nboth\tO\nin\tO\npaclitaxel\tB-Chemical\nand\tO\ncisplatin\tB-Chemical\ninduced\tO\nneurotoxicity\tB-Disease\n.\tO\n\nAlpha\tB-Chemical\n-\tI-Chemical\nlipoic\tI-Chemical\nacid\tI-Chemical\nprotects\tO\nsensory\tO\nneurons\tO\nthrough\tO\nits\tO\nanti\tO\n-\tO\noxidant\tO\nand\tO\nmitochondrial\tO\nregulatory\tO\nfunctions\tO\n,\tO\npossibly\tO\ninducing\tO\nthe\tO\nexpression\tO\nof\tO\nfrataxin\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nalpha\tB-Chemical\n-\tI-Chemical\nlipoic\tI-Chemical\nacid\tI-Chemical\nmight\tO\nreduce\tO\nthe\tO\nrisk\tO\nof\tO\ndeveloping\tO\nperipheral\tB-Disease\nnerve\tI-Disease\ntoxicity\tI-Disease\nin\tO\npatients\tO\nundergoing\tO\nchemotherapy\tO\nand\tO\nencourage\tO\nfurther\tO\nconfirmatory\tO\nclinical\tO\ntrials\tO\n.\tO\n\nToxicity\tB-Disease\nin\tO\nrhesus\tO\nmonkeys\tO\nfollowing\tO\nadministration\tO\nof\tO\nthe\tO\n8\tB-Chemical\n-\tI-Chemical\naminoquinoline\tI-Chemical\n8\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\namino\tI-Chemical\n-\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nmethylbutyl\tI-Chemical\n)\tI-Chemical\namino\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\nhexyloxy\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\nmethoxy\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethylquinoline\tI-Chemical\n(\tO\nWR242511\tB-Chemical\n)\tO\n.\tO\n\nINTRODUCTION\tO\n:\tO\nMany\tO\nsubstances\tO\nthat\tO\nform\tO\nmethemoglobin\tO\n(\tO\nMHb\tO\n)\tO\neffectively\tO\ncounter\tO\ncyanide\tO\n(\tO\nCN\tO\n)\tO\ntoxicity\tB-Disease\n.\tO\n\nAlthough\tO\nMHb\tO\nformers\tO\nare\tO\ngenerally\tO\napplied\tO\nas\tO\ntreatments\tO\nfor\tO\nCN\tO\npoisoning\tB-Disease\n,\tO\nit\tO\nhas\tO\nbeen\tO\nproposed\tO\nthat\tO\na\tO\nstable\tO\n,\tO\nlong\tO\n-\tO\nacting\tO\nMHb\tO\nformer\tO\ncould\tO\nserve\tO\nas\tO\na\tO\nCN\tO\npretreatment\tO\n.\tO\n\nUsing\tO\nthis\tO\nrationale\tO\n,\tO\nthe\tO\n8\tB-Chemical\n-\tI-Chemical\naminoquinoline\tI-Chemical\nWR242511\tB-Chemical\n,\tO\na\tO\npotent\tO\nlong\tO\n-\tO\nlasting\tO\nMHb\tO\nformer\tO\nin\tO\nrodents\tO\nand\tO\nbeagle\tO\ndogs\tO\n,\tO\nwas\tO\nstudied\tO\nin\tO\nthe\tO\nrhesus\tO\nmonkey\tO\nfor\tO\nadvanced\tO\ndevelopment\tO\nas\tO\na\tO\npotential\tO\nCN\tO\npretreatment\tO\n.\tO\n\nMETHODS\tO\n:\tO\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nWR242511\tB-Chemical\nwas\tO\nadministered\tO\nintravenously\tO\n(\tO\nIV\tO\n)\tO\nin\tO\n2\tO\nfemale\tO\nand\tO\n4\tO\nmale\tO\nrhesus\tO\nmonkeys\tO\nin\tO\ndoses\tO\nof\tO\n3\tO\n.\tO\n5\tO\nand\tO\n/\tO\nor\tO\n7\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n;\tO\na\tO\nsingle\tO\nmale\tO\nalso\tO\nreceived\tO\nWR242511\tB-Chemical\norally\tO\n(\tO\nPO\tO\n)\tO\nat\tO\n7\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nHealth\tO\nstatus\tO\nand\tO\nMHb\tO\nlevels\tO\nwere\tO\nmonitored\tO\nfollowing\tO\nexposure\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nselected\tO\ndoses\tO\nof\tO\nWR242511\tB-Chemical\n,\tO\nwhich\tO\nproduced\tO\nsignificant\tO\nmethemoglobinemia\tB-Disease\nin\tO\nbeagle\tO\ndogs\tO\nin\tO\nearlier\tO\nstudies\tO\nconducted\tO\nelsewhere\tO\n,\tO\nproduced\tO\nvery\tO\nlittle\tO\nMHb\tO\n(\tO\nmean\tO\n<\tO\n2\tO\n.\tO\n0\tO\n%\tO\n)\tO\nin\tO\nthe\tO\nrhesus\tO\nmonkey\tO\n.\tO\n\nFurthermore\tO\n,\tO\ntransient\tO\nhemoglobinuria\tB-Disease\nwas\tO\nnoted\tO\napproximately\tO\n60\tO\nminutes\tO\npostinjection\tO\nof\tO\nWR242511\tB-Chemical\n(\tO\n3\tO\n.\tO\n5\tO\nor\tO\n7\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nand\tO\n2\tO\nlethalities\tO\noccurred\tO\n(\tO\none\tO\nIV\tO\nand\tO\none\tO\nPO\tO\n)\tO\nfollowing\tO\nthe\tO\n7\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\ndose\tO\n.\tO\n\nMyoglobinuria\tB-Disease\nwas\tO\nalso\tO\nobserved\tO\nfollowing\tO\nthe\tO\n7\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\ndose\tO\n.\tO\n\nHistopathology\tO\nanalyses\tO\nin\tO\nthe\tO\n2\tO\nanimals\tO\nthat\tO\ndied\tO\nrevealed\tO\nliver\tB-Disease\nand\tI-Disease\nkidney\tI-Disease\ntoxicity\tI-Disease\n,\tO\nwith\tO\ngreater\tO\nseverity\tO\nin\tO\nthe\tO\norally\tO\n-\tO\ntreated\tO\nanimal\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\ndata\tO\ndemonstrate\tO\ndirect\tO\nand\tO\n/\tO\nor\tO\nindirect\tO\ndrug\tO\n-\tO\ninduced\tO\ntoxicity\tB-Disease\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nWR242511\tB-Chemical\nshould\tO\nnot\tO\nbe\tO\npursued\tO\nas\tO\na\tO\npretreatment\tO\nfor\tO\nCN\tO\npoisoning\tB-Disease\nunless\tO\nthe\tO\nanti\tO\n-\tO\nCN\tO\ncharacteristics\tO\nof\tO\nthis\tO\ncompound\tO\ncan\tO\nbe\tO\nsuccessfully\tO\ndissociated\tO\nfrom\tO\nthose\tO\nproducing\tO\nundesirable\tO\ntoxicity\tB-Disease\n.\tO\n\nRepetitive\tO\ntranscranial\tO\nmagnetic\tO\nstimulation\tO\nfor\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nIn\tO\na\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\nsingle\tO\n-\tO\nblinded\tO\n,\tO\ncrossover\tO\nstudy\tO\n,\tO\nwe\tO\nassessed\tO\nthe\tO\neffect\tO\nof\tO\n\"\tO\nreal\tO\n\"\tO\nrepetitive\tO\ntranscranial\tO\nmagnetic\tO\nstimulation\tO\n(\tO\nrTMS\tO\n)\tO\nversus\tO\n\"\tO\nsham\tO\n\"\tO\nrTMS\tO\n(\tO\nplacebo\tO\n)\tO\non\tO\npeak\tO\ndose\tO\ndyskinesias\tB-Disease\nin\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\n.\tO\n\nTen\tO\npatients\tO\nwith\tO\nPD\tB-Disease\nand\tO\nprominent\tO\ndyskinesias\tB-Disease\nhad\tO\nrTMS\tO\n(\tO\n1\tO\n,\tO\n800\tO\npulses\tO\n;\tO\n1\tO\nHz\tO\nrate\tO\n)\tO\ndelivered\tO\nover\tO\nthe\tO\nmotor\tO\ncortex\tO\nfor\tO\n4\tO\nconsecutive\tO\ndays\tO\ntwice\tO\n,\tO\nonce\tO\nreal\tO\nstimuli\tO\nand\tO\nonce\tO\nsham\tO\nstimulation\tO\nwere\tO\nused\tO\n;\tO\nevaluations\tO\nwere\tO\ndone\tO\nat\tO\nthe\tO\nbaseline\tO\nand\tO\n1\tO\nday\tO\nafter\tO\nthe\tO\nend\tO\nof\tO\neach\tO\nof\tO\nthe\tO\ntreatment\tO\nseries\tO\n.\tO\n\nDirect\tO\ncomparison\tO\nbetween\tO\nsham\tO\nand\tO\nreal\tO\nrTMS\tO\neffects\tO\nshowed\tO\nno\tO\nsignificant\tO\ndifference\tO\nin\tO\nclinician\tO\n-\tO\nassessed\tO\ndyskinesia\tB-Disease\nseverity\tO\n.\tO\n\nHowever\tO\n,\tO\ncomparison\tO\nwith\tO\nthe\tO\nbaseline\tO\nshowed\tO\nsmall\tO\nbut\tO\nsignificant\tO\nreduction\tO\nin\tO\ndyskinesia\tB-Disease\nseverity\tO\nfollowing\tO\nreal\tO\nrTMS\tO\nbut\tO\nnot\tO\nplacebo\tO\n.\tO\n\nThe\tO\nmajor\tO\neffect\tO\nwas\tO\non\tO\ndystonia\tB-Disease\nsubscore\tO\n.\tO\n\nSimilarly\tO\n,\tO\nin\tO\npatient\tO\ndiaries\tO\n,\tO\nalthough\tO\nboth\tO\ntreatments\tO\ncaused\tO\nreduction\tO\nin\tO\nsubjective\tO\ndyskinesia\tB-Disease\nscores\tO\nduring\tO\nthe\tO\ndays\tO\nof\tO\nintervention\tO\n,\tO\nthe\tO\neffect\tO\nwas\tO\nsustained\tO\nfor\tO\n3\tO\ndays\tO\nafter\tO\nthe\tO\nintervention\tO\nfor\tO\nthe\tO\nreal\tO\nrTMS\tO\nonly\tO\n.\tO\n\nFollowing\tO\nrTMS\tO\n,\tO\nno\tO\nside\tO\neffects\tO\nand\tO\nno\tO\nadverse\tO\neffects\tO\non\tO\nmotor\tO\nfunction\tO\nand\tO\nPD\tB-Disease\nsymptoms\tO\nwere\tO\nnoted\tO\n.\tO\n\nThe\tO\nresults\tO\nsuggest\tO\nthe\tO\nexistence\tO\nof\tO\nresidual\tO\nbeneficial\tO\nclinical\tO\naftereffects\tO\nof\tO\nconsecutive\tO\ndaily\tO\napplications\tO\nof\tO\nlow\tO\n-\tO\nfrequency\tO\nrTMS\tO\non\tO\ndyskinesias\tB-Disease\nin\tO\nPD\tB-Disease\n.\tO\n\nThe\tO\neffects\tO\nmay\tO\nbe\tO\nfurther\tO\nexploited\tO\nfor\tO\npotential\tO\ntherapeutic\tO\nuses\tO\n.\tO\n\nIntracavernous\tO\nepinephrine\tB-Chemical\n:\tO\na\tO\nminimally\tO\ninvasive\tO\ntreatment\tO\nfor\tO\npriapism\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tO\n\nPriapism\tB-Disease\nis\tO\nthe\tO\nprolonged\tO\nerection\tO\nof\tO\nthe\tO\npenis\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nsexual\tO\narousal\tO\n.\tO\n\nA\tO\n45\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\n,\tO\nan\tO\nadmitted\tO\nfrequent\tO\ncocaine\tB-Chemical\nuser\tO\n,\tO\npresented\tO\nto\tO\nthe\tO\nEmergency\tO\nDepartment\tO\n(\tO\nED\tO\n)\tO\non\tO\ntwo\tO\nseparate\tO\noccasions\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\npriapism\tB-Disease\nafter\tO\ncocaine\tB-Chemical\nuse\tO\n.\tO\n\nThe\tO\nmanagement\tO\noptions\tO\nin\tO\nthe\tO\nED\tO\n,\tO\nas\tO\nexemplified\tO\nby\tO\nfour\tO\nindividual\tO\ncase\tO\nreports\tO\n,\tO\nin\tO\nparticular\tO\nthe\tO\nuse\tO\nof\tO\na\tO\nminimally\tO\ninvasive\tO\nmethod\tO\nof\tO\nintracorporal\tO\nepinephrine\tB-Chemical\ninstillation\tO\n,\tO\nare\tO\ndiscussed\tO\n.\tO\n\nProphylactic\tO\nuse\tO\nof\tO\nlamivudine\tB-Chemical\nwith\tO\nchronic\tO\nimmunosuppressive\tO\ntherapy\tO\nfor\tO\nrheumatologic\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nreport\tO\nour\tO\nexperience\tO\nconcerning\tO\nthe\tO\neffectiveness\tO\nof\tO\nthe\tO\nprophylactic\tO\nadministration\tO\nof\tO\nlamivudine\tB-Chemical\nin\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nvirus\tI-Chemical\nsurface\tI-Chemical\nantigen\tI-Chemical\n(\tO\nHBs\tB-Chemical\nAg\tI-Chemical\n)\tO\npositive\tO\npatients\tO\nwith\tO\nrheumatologic\tB-Disease\ndisease\tI-Disease\n.\tO\n\nFrom\tO\nJune\tO\n2004\tO\nto\tO\nOctober\tO\n2006\tO\n,\tO\n11\tO\nHBs\tB-Chemical\nAg\tI-Chemical\npositive\tO\npatients\tO\nwith\tO\nrheumatologic\tB-Disease\ndiseases\tI-Disease\n,\tO\nwho\tO\nwere\tO\non\tO\nboth\tO\nimmunosuppressive\tO\nand\tO\nprophylactic\tO\nlamivudine\tB-Chemical\ntherapies\tO\n,\tO\nwere\tO\nretrospectively\tO\nassessed\tO\n.\tO\n\nLiver\tO\nfunction\tO\ntests\tO\n,\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\n(\tO\nHBV\tO\n)\tO\nserologic\tO\nmarkers\tO\n,\tO\nand\tO\nHBV\tO\nDNA\tO\nlevels\tO\nof\tO\nthe\tO\npatients\tO\nduring\tO\nfollow\tO\n-\tO\nup\tO\nwere\tO\nobtained\tO\nfrom\tO\nhospital\tO\nfile\tO\nrecords\tO\n.\tO\n\nEleven\tO\npatients\tO\n(\tO\nsix\tO\nmale\tO\n)\tO\nwith\tO\nmedian\tO\nage\tO\n47\tO\nyears\tO\n(\tO\nrange\tO\n27\tO\n-\tO\n73\tO\n)\tO\n,\tO\nmedian\tO\ndisease\tO\nduration\tO\n50\tO\nmonths\tO\n(\tO\nrange\tO\n9\tO\n-\tO\n178\tO\n)\tO\nand\tO\nmedian\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\nof\tO\npatients\tO\n13\tO\n.\tO\n8\tO\nmonths\tO\n(\tO\nrange\tO\n5\tO\n-\tO\n27\tO\n)\tO\nwere\tO\nenrolled\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nLamivudine\tB-Chemical\ntherapy\tO\nwas\tO\nstarted\tO\n3\tO\n-\tO\n7\tO\ndays\tO\nprior\tO\nto\tO\nimmunosuppressive\tO\ntherapy\tO\nin\tO\nall\tO\npatients\tO\n.\tO\n\nBaseline\tO\n,\tO\nliver\tO\nfunction\tO\ntests\tO\nwere\tO\nelevated\tO\nin\tO\ntwo\tO\npatients\tO\n(\tO\nfourth\tO\npatient\tO\n:\tO\nALT\tO\n:\tO\n122\tO\nIU\tO\n/\tO\nl\tO\n,\tO\nAST\tO\n:\tO\n111\tO\nIU\tO\n/\tO\nl\tO\n,\tO\ntenth\tO\npatient\tO\n:\tO\nALT\tO\n:\tO\n294\tO\nIU\tO\n/\tO\nl\tO\n,\tO\nAST\tO\n:\tO\n274\tO\nIU\tO\n/\tO\nl\tO\n,\tO\nwith\tO\nminimal\tO\nchanges\tO\nin\tO\nthe\tO\nliver\tO\nbiopsy\tO\nin\tO\nboth\tO\n)\tO\n.\tO\n\nShortly\tO\nafter\tO\ntreatment\tO\ntheir\tO\ntests\tO\nnormalized\tO\nand\tO\nduring\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\nnone\tO\nof\tO\nthe\tO\npatients\tO\nhad\tO\nabnormal\tB-Disease\nliver\tI-Disease\nfunction\tI-Disease\ntests\tO\n.\tO\n\nIn\tO\nfour\tO\npatients\tO\nHBV\tO\nDNA\tO\nlevels\tO\nwere\tO\nhigher\tO\nthan\tO\nnormal\tO\nat\tO\nbaseline\tO\n.\tO\n\nTwo\tO\nof\tO\nthese\tO\nnormalized\tO\nand\tO\nthe\tO\nothers\tO\nincreased\tO\nlater\tO\n.\tO\n\nIn\tO\nthree\tO\nadditional\tO\npatients\tO\n,\tO\nHBV\tO\nDNA\tO\nlevels\tO\nwere\tO\nincreased\tO\nduring\tO\nfollow\tO\n-\tO\nup\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\npatients\tO\nhad\tO\nsignificant\tO\nclinical\tO\nsings\tO\nof\tO\nHBV\tO\nactivation\tO\n.\tO\n\nLamivudine\tB-Chemical\nwas\tO\nwell\tO\ntolerated\tO\nand\tO\nwas\tO\ncontinued\tO\nin\tO\nall\tO\npatients\tO\n.\tO\n\nProphylactic\tO\nadministration\tO\nof\tO\nlamivudine\tB-Chemical\nin\tO\npatients\tO\nwho\tO\nrequired\tO\nimmunosuppressive\tO\ntherapy\tO\nseems\tO\nto\tO\nbe\tO\nsafe\tO\n,\tO\nwell\tO\ntolerated\tO\nand\tO\neffective\tO\nin\tO\npreventing\tO\nHBV\tO\nreactivation\tO\n.\tO\n\nEffect\tO\nof\tO\ngreen\tB-Chemical\ntea\tI-Chemical\nand\tO\nvitamin\tB-Chemical\nE\tI-Chemical\ncombination\tO\nin\tO\nisoproterenol\tB-Chemical\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\naimed\tO\nto\tO\ninvestigate\tO\nthe\tO\ncombined\tO\neffects\tO\nof\tO\ngreen\tB-Chemical\ntea\tI-Chemical\nand\tO\nvitamin\tB-Chemical\nE\tI-Chemical\non\tO\nheart\tO\nweight\tO\n,\tO\nbody\tO\nweight\tO\n,\tO\nserum\tO\nmarker\tO\nenzymes\tO\n,\tO\nlipid\tO\nperoxidation\tO\n,\tO\nendogenous\tO\nantioxidants\tO\nand\tO\nmembrane\tO\nbound\tO\nATPases\tO\nin\tO\nisoproterenol\tB-Chemical\n(\tO\nISO\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nAdult\tO\nmale\tO\nalbino\tO\nrats\tO\n,\tO\ntreated\tO\nwith\tO\nISO\tB-Chemical\n(\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nfor\tO\n2\tO\ndays\tO\nat\tO\nan\tO\ninterval\tO\nof\tO\n24\tO\nh\tO\ncaused\tO\na\tO\nsignificant\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nelevation\tO\nof\tO\nheart\tO\nweight\tO\n,\tO\nserum\tO\nmarker\tO\nenzymes\tO\n,\tO\nlipid\tO\nperoxidation\tO\nand\tO\nCa\tB-Chemical\n+\tO\n2\tO\nATPase\tO\nlevel\tO\nwhereas\tO\nthere\tO\nwas\tO\na\tO\nsignificant\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\ndecrease\tO\nin\tO\nbody\tO\nweight\tO\n,\tO\nendogenous\tO\nantioxidants\tO\n,\tO\nNa\tB-Chemical\n+\tO\n/\tO\nK\tB-Chemical\n+\tO\nATPase\tO\nand\tO\nMg\tB-Chemical\n+\tO\n2\tO\nATPase\tO\nlevels\tO\n.\tO\n\nAdministration\tO\nof\tO\ngreen\tB-Chemical\ntea\tI-Chemical\n(\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\nand\tO\nvitamin\tB-Chemical\nE\tI-Chemical\n(\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\ntogether\tO\nfor\tO\n30\tO\nconsecutive\tO\ndays\tO\nand\tO\nchallenged\tO\nwith\tO\nISO\tB-Chemical\non\tO\nthe\tO\nday\tO\n29th\tO\nand\tO\n30th\tO\n,\tO\nshowed\tO\na\tO\nsignificant\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\ndecrease\tO\nin\tO\nheart\tO\nweight\tO\n,\tO\nserum\tO\nmarker\tO\nenzymes\tO\n,\tO\nlipid\tO\nperoxidation\tO\n,\tO\nCa\tB-Chemical\n+\tO\n2\tO\nATPase\tO\nand\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nthe\tO\nbody\tO\nweight\tO\n,\tO\nendogenous\tO\nantioxidants\tO\n,\tO\nNa\tB-Chemical\n+\tO\n/\tO\nK\tB-Chemical\n+\tO\nATPase\tO\nand\tO\nMg\tB-Chemical\n+\tO\n2\tO\nATPase\tO\nwhen\tO\ncompared\tO\nwith\tO\nISO\tB-Chemical\ntreated\tO\ngroup\tO\nand\tO\ngreen\tB-Chemical\ntea\tI-Chemical\nor\tO\nvitamin\tB-Chemical\nE\tI-Chemical\nalone\tO\ntreated\tO\ngroups\tO\n.\tO\n\nThese\tO\nfindings\tO\nindicate\tO\nthe\tO\nsynergistic\tO\nprotective\tO\neffect\tO\nof\tO\ngreen\tB-Chemical\ntea\tI-Chemical\nand\tO\nvitamin\tB-Chemical\nE\tI-Chemical\nduring\tO\nISO\tB-Chemical\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nIrreversible\tO\ndamage\tO\nto\tO\nthe\tO\nmedullary\tO\ninterstitium\tO\nin\tO\nexperimental\tO\nanalgesic\tO\nnephropathy\tB-Disease\nin\tO\nF344\tO\nrats\tO\n.\tO\n\nRenal\tB-Disease\npapillary\tI-Disease\nnecrosis\tI-Disease\n(\tO\nRPN\tB-Disease\n)\tO\nand\tO\na\tO\ndecreased\tO\nurinary\tO\nconcentrating\tO\nability\tO\ndeveloped\tO\nduring\tO\ncontinuous\tO\nlong\tO\n-\tO\nterm\tO\ntreatment\tO\nwith\tO\naspirin\tB-Chemical\nand\tO\nparacetamol\tB-Chemical\nin\tO\nfemale\tO\nFischer\tO\n344\tO\nrats\tO\n.\tO\n\nRenal\tO\nstructure\tO\nand\tO\nconcentrating\tO\nability\tO\nwere\tO\nexamined\tO\nafter\tO\na\tO\nrecovery\tO\nperiod\tO\nof\tO\nup\tO\nto\tO\n18\tO\nweeks\tO\n,\tO\nwhen\tO\nno\tO\nanalgesics\tO\nwere\tO\ngiven\tO\n,\tO\nto\tO\ninvestigate\tO\nwhether\tO\nthe\tO\nanalgesic\tO\n-\tO\ninduced\tO\nchanges\tO\nwere\tO\nreversible\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nevidence\tO\nof\tO\nrepair\tO\nto\tO\nthe\tO\ndamaged\tO\nmedullary\tO\ninterstitial\tO\nmatrix\tO\n,\tO\nor\tO\nproliferation\tO\nof\tO\nremaining\tO\nundamaged\tO\ntype\tO\n1\tO\nmedullary\tO\ninterstitial\tO\ncells\tO\nafter\tO\nthe\tO\nrecovery\tO\nperiod\tO\nfollowing\tO\nanalgesic\tO\ntreatment\tO\n.\tO\n\nThe\tO\nrecovery\tO\nof\tO\nurinary\tO\nconcentrating\tO\nability\tO\nwas\tO\nrelated\tO\nto\tO\nthe\tO\nlength\tO\nof\tO\nanalgesic\tO\ntreatment\tO\nand\tO\nthe\tO\nextent\tO\nof\tO\nthe\tO\nresulting\tO\ninner\tO\nmedullary\tO\nstructural\tO\ndamage\tO\n.\tO\n\nDuring\tO\nthe\tO\nearly\tO\nstages\tO\nof\tO\nanalgesic\tO\ntreatment\tO\n,\tO\nthe\tO\nchanges\tO\nin\tO\nurinary\tO\nconcentrating\tO\nability\tO\nwere\tO\nreversible\tO\n,\tO\nbut\tO\nafter\tO\nprolonged\tO\nanalgesic\tO\ntreatment\tO\n,\tO\nmaximum\tO\nurinary\tO\nconcentrating\tO\nability\tO\nfailed\tO\nto\tO\nrecover\tO\n.\tO\n\nThis\tO\nstudy\tO\nshows\tO\nthat\tO\nprolonged\tO\nanalgesic\tO\ntreatment\tO\nin\tO\nFischer\tO\n344\tO\nrats\tO\ncauses\tO\nprogressive\tO\nand\tO\nirreversible\tO\ndamage\tO\nto\tO\nthe\tO\ninterstitial\tO\nmatrix\tO\nand\tO\ntype\tO\n1\tO\ninterstitial\tO\ncells\tO\nleading\tO\nto\tO\nRPN\tB-Disease\n.\tO\n\nThe\tO\nassociated\tO\nurinary\tO\nconcentrating\tO\ndefect\tO\nis\tO\nreversible\tO\nonly\tO\nduring\tO\nthe\tO\nearly\tO\nstages\tO\nof\tO\nstructural\tO\ndamage\tO\nto\tO\nthe\tO\ninner\tO\nmedulla\tO\n.\tO\n\nTestosterone\tB-Chemical\n-\tO\ndependent\tO\nhypertension\tB-Disease\nand\tO\nupregulation\tO\nof\tO\nintrarenal\tO\nangiotensinogen\tO\nin\tO\nDahl\tO\nsalt\tB-Chemical\n-\tO\nsensitive\tO\nrats\tO\n.\tO\n\nBlood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\nis\tO\nmore\tO\nsalt\tB-Chemical\nsensitive\tO\nin\tO\nmen\tO\nthan\tO\nin\tO\npremenopausal\tO\nwomen\tO\n.\tO\n\nIn\tO\nDahl\tO\nsalt\tB-Chemical\n-\tO\nsensitive\tO\nrats\tO\n(\tO\nDS\tO\n)\tO\n,\tO\nhigh\tO\n-\tO\nsalt\tB-Chemical\n(\tO\nHS\tO\n)\tO\ndiet\tO\nincreases\tO\nBP\tO\nmore\tO\nin\tO\nmales\tO\nthan\tO\nfemales\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\nthe\tO\nsystemic\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\n,\tO\nwhich\tO\nis\tO\nsuppressed\tO\nin\tO\nresponse\tO\nto\tO\nHS\tO\nin\tO\nmale\tO\nDS\tO\n,\tO\nintrarenal\tO\nangiotensinogen\tO\nexpression\tO\nis\tO\nincreased\tO\n,\tO\nand\tO\nintrarenal\tO\nlevels\tO\nof\tO\nANG\tO\nII\tO\nare\tO\nnot\tO\nsuppressed\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nthe\tO\nhypothesis\tO\nwas\tO\ntested\tO\nthat\tO\nthere\tO\nis\tO\na\tO\nsexual\tO\ndimorphism\tO\nin\tO\nHS\tO\n-\tO\ninduced\tO\nupregulation\tO\nof\tO\nintrarenal\tO\nangiotensinogen\tO\nmediated\tO\nby\tO\ntestosterone\tB-Chemical\nthat\tO\nalso\tO\ncauses\tO\nincreases\tO\nin\tO\nBP\tO\nand\tO\nrenal\tB-Disease\ninjury\tI-Disease\n.\tO\n\nOn\tO\na\tO\nlow\tO\n-\tO\nsalt\tB-Chemical\n(\tO\nLS\tO\n)\tO\ndiet\tO\n,\tO\nmale\tO\nDS\tO\nhad\tO\nhigher\tO\nlevels\tO\nof\tO\nintrarenal\tO\nangiotensinogen\tO\nmRNA\tO\nthan\tO\nfemales\tO\n.\tO\n\nHS\tO\ndiet\tO\nfor\tO\n4\tO\nwk\tO\nincreased\tO\nrenal\tO\ncortical\tO\nangiotensinogen\tO\nmRNA\tO\nand\tO\nprotein\tO\nonly\tO\nin\tO\nmale\tO\nDS\tO\n,\tO\nwhich\tO\nwas\tO\nprevented\tO\nby\tO\ncastration\tO\n.\tO\n\nOvariectomy\tO\nof\tO\nfemale\tO\nDS\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nintrarenal\tO\nangiotensinogen\tO\nexpression\tO\non\tO\neither\tO\ndiet\tO\n.\tO\n\nRadiotelemetric\tO\nBP\tO\nwas\tO\nsimilar\tO\nbetween\tO\nmales\tO\nand\tO\ncastrated\tO\nrats\tO\non\tO\nLS\tO\ndiet\tO\n.\tO\n\nHS\tO\ndiet\tO\nfor\tO\n4\tO\nwk\tO\ncaused\tO\na\tO\nprogressive\tO\nincrease\tO\nin\tO\nBP\tO\n,\tO\nprotein\tO\nand\tO\nalbumin\tO\nexcretion\tO\n,\tO\nand\tO\nglomerular\tB-Disease\nsclerosis\tI-Disease\nin\tO\nmale\tO\nDS\tO\nrats\tO\n,\tO\nwhich\tO\nwere\tO\nattenuated\tO\nby\tO\ncastration\tO\n.\tO\n\nTestosterone\tB-Chemical\nreplacement\tO\nin\tO\ncastrated\tO\nDS\tO\nrats\tO\nincreased\tO\nBP\tO\n,\tO\nrenal\tB-Disease\ninjury\tI-Disease\n,\tO\nand\tO\nupregulation\tO\nof\tO\nrenal\tO\nangiotensinogen\tO\nassociated\tO\nwith\tO\nHS\tO\ndiet\tO\n.\tO\n\nTestosterone\tB-Chemical\ncontributes\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\nhypertension\tB-Disease\nand\tO\nrenal\tB-Disease\ninjury\tI-Disease\nin\tO\nmale\tO\nDS\tO\nrats\tO\non\tO\nHS\tO\ndiet\tO\npossibly\tO\nthrough\tO\nupregulation\tO\nof\tO\nthe\tO\nintrarenal\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\n.\tO\n\nExplicit\tO\nepisodic\tO\nmemory\tO\nfor\tO\nsensory\tO\n-\tO\ndiscriminative\tO\ncomponents\tO\nof\tO\ncapsaicin\tB-Chemical\n-\tO\ninduced\tO\npain\tB-Disease\n:\tO\nimmediate\tO\nand\tO\ndelayed\tO\nratings\tO\n.\tO\n\nPain\tB-Disease\nmemory\tO\nis\tO\nthought\tO\nto\tO\naffect\tO\nfuture\tO\npain\tB-Disease\nsensitivity\tO\nand\tO\nthus\tO\ncontribute\tO\nto\tO\nclinical\tO\npain\tB-Disease\nconditions\tO\n.\tO\n\nSystematic\tO\ninvestigations\tO\nof\tO\nthe\tO\nhuman\tO\ncapacity\tO\nto\tO\nremember\tO\nsensory\tO\nfeatures\tO\nof\tO\nexperimental\tO\npain\tB-Disease\nare\tO\nsparse\tO\n.\tO\n\nIn\tO\norder\tO\nto\tO\naddress\tO\nlong\tO\n-\tO\nterm\tO\npain\tB-Disease\nmemory\tO\n,\tO\nnine\tO\nhealthy\tO\nmale\tO\nvolunteers\tO\nreceived\tO\nintradermal\tO\ninjections\tO\nof\tO\nthree\tO\ndoses\tO\nof\tO\ncapsaicin\tB-Chemical\n(\tO\n0\tO\n.\tO\n05\tO\n,\tO\n1\tO\nand\tO\n20\tO\nmicrog\tO\n,\tO\nseparated\tO\nby\tO\n15\tO\nmin\tO\nbreaks\tO\n)\tO\n,\tO\neach\tO\ngiven\tO\nthree\tO\ntimes\tO\nin\tO\na\tO\nbalanced\tO\ndesign\tO\nacross\tO\nthree\tO\nsessions\tO\nat\tO\none\tO\nweek\tO\nintervals\tO\n.\tO\n\nPain\tB-Disease\nrating\tO\nwas\tO\nperformed\tO\nusing\tO\na\tO\ncomputerized\tO\nvisual\tO\nanalogue\tO\nscale\tO\n(\tO\n0\tO\n-\tO\n100\tO\n)\tO\ndigitized\tO\nat\tO\n1\tO\n/\tO\ns\tO\n,\tO\neither\tO\nimmediately\tO\nonline\tO\nor\tO\none\tO\nhour\tO\nor\tO\none\tO\nday\tO\nafter\tO\ninjection\tO\n.\tO\n\nSubjects\tO\nalso\tO\nrecalled\tO\ntheir\tO\npains\tB-Disease\none\tO\nweek\tO\nlater\tO\n.\tO\n\nCapsaicin\tB-Chemical\ninjection\tO\nreliably\tO\ninduced\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nflare\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nwithout\tO\nany\tO\ndifference\tO\nwithin\tO\nor\tO\nacross\tO\nsessions\tO\n.\tO\n\nThe\tO\nstrong\tO\nburning\tO\npain\tB-Disease\ndecayed\tO\nexponentially\tO\nwithin\tO\na\tO\nfew\tO\nminutes\tO\n.\tO\n\nSubjects\tO\nwere\tO\nable\tO\nto\tO\nreliably\tO\ndiscriminate\tO\npain\tB-Disease\nmagnitude\tO\nand\tO\nduration\tO\nacross\tO\ncapsaicin\tB-Chemical\ndoses\tO\n(\tO\nboth\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nregardless\tO\nof\tO\nwhether\tO\nfirst\tO\n-\tO\ntime\tO\nratings\tO\nwere\tO\nrequested\tO\nimmediately\tO\n,\tO\nafter\tO\none\tO\nhour\tO\nor\tO\nafter\tO\none\tO\nday\tO\n.\tO\n\nPain\tB-Disease\nrecall\tO\nafter\tO\none\tO\nweek\tO\nwas\tO\nsimilarly\tO\nprecise\tO\n(\tO\nmagnitude\tO\n:\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n,\tO\nduration\tO\n:\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCorrelation\tO\nwith\tO\nrating\tO\nrecall\tO\nafter\tO\none\tO\nweek\tO\nwas\tO\nbest\tO\nwhen\tO\nfirst\tO\n-\tO\ntime\tO\nratings\tO\nwere\tO\nrequested\tO\nas\tO\nlate\tO\nas\tO\none\tO\nday\tO\nafter\tO\ninjection\tO\n(\tO\nR\tO\n(\tO\n2\tO\n)\tO\n=\tO\n0\tO\n.\tO\n79\tO\n)\tO\nindicating\tO\nthat\tO\nboth\tO\nrating\tO\nretrievals\tO\nutilized\tO\nsimilar\tO\nmemory\tO\ntraces\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\na\tO\nreliable\tO\nmemory\tO\nfor\tO\nmagnitude\tO\nand\tO\nduration\tO\nof\tO\nexperimentally\tO\ninduced\tO\npain\tB-Disease\n.\tO\n\nThe\tO\ndata\tO\nfurther\tO\nsuggest\tO\nthat\tO\nthe\tO\nconsolidation\tO\nof\tO\nthis\tO\nmemory\tO\nis\tO\nan\tO\nimportant\tO\ninterim\tO\nstage\tO\n,\tO\nand\tO\nmay\tO\ntake\tO\nup\tO\nto\tO\none\tO\nday\tO\n.\tO\n\nSevere\tO\nand\tO\nlong\tO\nlasting\tO\ncholestasis\tB-Disease\nafter\tO\nhigh\tO\n-\tO\ndose\tO\nco\tB-Chemical\n-\tI-Chemical\ntrimoxazole\tI-Chemical\ntreatment\tO\nfor\tO\nPneumocystis\tB-Disease\npneumonia\tI-Disease\nin\tO\nHIV\tB-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\n-\tO\n-\tO\na\tO\nreport\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nPneumocystis\tB-Disease\npneumonia\tI-Disease\n(\tO\nPCP\tB-Disease\n)\tO\n,\tO\na\tO\ncommon\tO\nopportunistic\tB-Disease\ninfection\tI-Disease\nin\tO\nHIV\tB-Disease\n-\tI-Disease\ninfected\tI-Disease\nindividuals\tO\n,\tO\nis\tO\ngenerally\tO\ntreated\tO\nwith\tO\nhigh\tO\ndoses\tO\nof\tO\nco\tB-Chemical\n-\tI-Chemical\ntrimoxazole\tI-Chemical\n.\tO\n\nHowever\tO\n,\tO\ntreatment\tO\nis\tO\noften\tO\nlimited\tO\nby\tO\nadverse\tO\neffects\tO\n.\tO\n\nHere\tO\n,\tO\nwe\tO\nreport\tO\ntwo\tO\ncases\tO\nof\tO\nseverely\tO\nimmunocompromised\tO\nHIV\tB-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\nwho\tO\ndeveloped\tO\nsevere\tO\nintrahepatic\tB-Disease\ncholestasis\tI-Disease\n,\tO\nand\tO\nin\tO\none\tO\npatient\tO\nlesions\tO\nmimicking\tO\nliver\tB-Disease\nabscess\tI-Disease\nformation\tO\non\tO\nradiologic\tO\nexams\tO\n,\tO\nduring\tO\nco\tB-Chemical\n-\tI-Chemical\ntrimoxazole\tI-Chemical\ntreatment\tO\nfor\tO\nPCP\tB-Disease\n.\tO\n\nWhereas\tO\npatient\tO\n1\tO\nshowed\tO\nlesions\tO\nof\tO\nup\tO\nto\tO\n1\tO\ncm\tO\nreadily\tO\ndetectable\tO\non\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nunder\tO\nprolonged\tO\nco\tB-Chemical\n-\tI-Chemical\ntrimoxazole\tI-Chemical\ntreatment\tO\n,\tO\ntherapy\tO\nof\tO\npatient\tO\n2\tO\nwas\tO\nswitched\tO\nearly\tO\n.\tO\n\nBradykinin\tB-Chemical\nreceptors\tO\nantagonists\tO\nand\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsynthase\tO\ninhibitors\tO\nin\tO\nvincristine\tB-Chemical\nand\tO\nstreptozotocin\tB-Chemical\ninduced\tO\nhyperalgesia\tB-Disease\nin\tO\nchemotherapy\tO\nand\tO\ndiabetic\tB-Disease\nneuropathy\tI-Disease\nrat\tO\nmodel\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nThe\tO\ninfluence\tO\nof\tO\nan\tO\nirreversible\tO\ninhibitor\tO\nof\tO\nconstitutive\tO\nNO\tB-Chemical\nsynthase\tO\n(\tO\nL\tO\n-\tO\nNOArg\tO\n;\tO\n1\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\n,\tO\na\tO\nrelatively\tO\nselective\tO\ninhibitor\tO\nof\tO\ninducible\tO\nNO\tB-Chemical\nsynthase\tO\n(\tO\nL\tO\n-\tO\nNIL\tO\n;\tO\n1\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\nand\tO\na\tO\nrelatively\tO\nspecific\tO\ninhibitor\tO\nof\tO\nneuronal\tO\nNO\tB-Chemical\nsynthase\tO\n(\tO\n7\tO\n-\tO\nNI\tO\n;\tO\n0\tO\n.\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\n,\tO\non\tO\nantihyperalgesic\tO\naction\tO\nof\tO\nselective\tO\nantagonists\tO\nof\tO\nB2\tO\nand\tO\nB1\tO\nreceptors\tO\n:\tO\nD\tO\n-\tO\nArg\tO\n-\tO\n[\tO\nHyp3\tO\n,\tO\nThi5\tO\n,\tO\nD\tO\n-\tO\nTic7\tO\n,\tO\nOic8\tO\n]\tO\nbradykinin\tB-Chemical\n(\tO\nHOE\tB-Chemical\n140\tI-Chemical\n;\tO\n70\tO\nnmol\tO\n/\tO\nkg\tO\nip\tO\n)\tO\nor\tO\ndes\tB-Chemical\nArg10\tI-Chemical\nHOE\tI-Chemical\n140\tI-Chemical\n(\tO\n70\tO\nnmol\tO\n/\tO\nkg\tO\nip\tO\n)\tO\nrespectively\tO\n,\tO\nin\tO\nmodel\tO\nof\tO\ndiabetic\tB-Disease\n(\tI-Disease\nstreptozotocin\tI-Disease\n-\tI-Disease\ninduced\tI-Disease\n)\tI-Disease\nand\tI-Disease\ntoxic\tI-Disease\n(\tI-Disease\nvincristine\tI-Disease\n-\tI-Disease\ninduced\tI-Disease\n)\tI-Disease\nneuropathy\tI-Disease\nwas\tO\ninvestigated\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nchanges\tO\nin\tO\npain\tB-Disease\nthresholds\tO\nwere\tO\ndetermined\tO\nusing\tO\nmechanical\tO\nstimuli\tO\n-\tO\n-\tO\nthe\tO\nmodification\tO\nof\tO\nthe\tO\nclassic\tO\npaw\tO\nwithdrawal\tO\ntest\tO\ndescribed\tO\nby\tO\nRandall\tO\n-\tO\nSelitto\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nresults\tO\nof\tO\nthis\tO\npaper\tO\nconfirm\tO\nthat\tO\ninhibition\tO\nof\tO\nbradykinin\tB-Chemical\nreceptors\tO\nand\tO\ninducible\tO\nNO\tB-Chemical\nsynthase\tO\nbut\tO\nnot\tO\nneuronal\tO\nNO\tB-Chemical\nsynthase\tO\nactivity\tO\nreduces\tO\ndiabetic\tB-Disease\nhyperalgesia\tI-Disease\n.\tO\n\nPretreatment\tO\nwith\tO\nL\tO\n-\tO\nNOArg\tO\nand\tO\nL\tO\n-\tO\nNIL\tO\nbut\tO\nnot\tO\n7\tO\n-\tO\nNI\tO\n,\tO\nsignificantly\tO\nincreases\tO\nantihyperalgesic\tO\nactivity\tO\nboth\tO\nHOE\tB-Chemical\n140\tI-Chemical\nand\tO\ndes\tB-Chemical\nArg10\tI-Chemical\nHOE\tI-Chemical\n140\tI-Chemical\n.\tO\n\nIt\tO\nwas\tO\nalso\tO\nshown\tO\nthat\tO\nboth\tO\nproducts\tO\nof\tO\ninducible\tO\nNO\tB-Chemical\nsynthase\tO\nand\tO\nneuronal\tO\nNO\tB-Chemical\nsynthase\tO\nactivation\tO\nas\tO\nwell\tO\nas\tO\nbradykinin\tB-Chemical\nare\tO\ninvolved\tO\nin\tO\nhyperalgesia\tB-Disease\nproduced\tO\nby\tO\nvincristine\tB-Chemical\n.\tO\n\nMoreover\tO\n,\tO\nL\tO\n-\tO\nNOArg\tO\nand\tO\n7\tO\n-\tO\nNI\tO\nbut\tO\nnot\tO\nL\tO\n-\tO\nNIL\tO\nintensify\tO\nantihyperalgesic\tO\nactivity\tO\nof\tO\nHOE\tB-Chemical\n140\tI-Chemical\nor\tO\ndes\tB-Chemical\n-\tI-Chemical\nArg10HOE\tI-Chemical\n140\tI-Chemical\nin\tO\ntoxic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nResults\tO\nof\tO\nthese\tO\nstudies\tO\nsuggest\tO\nthat\tO\nB1\tO\nand\tO\nB2\tO\nreceptors\tO\nare\tO\nengaged\tO\nin\tO\ntransmission\tO\nof\tO\nnociceptive\tO\nstimuli\tO\nin\tO\nboth\tO\ndiabetic\tB-Disease\nand\tI-Disease\ntoxic\tI-Disease\nneuropathy\tI-Disease\n.\tO\n\nIn\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\nhyperalgesia\tB-Disease\n,\tO\ninducible\tO\nNO\tB-Chemical\nsynthase\tO\nparticipates\tO\nin\tO\npronociceptive\tO\nactivity\tO\nof\tO\nbradykinin\tB-Chemical\n,\tO\nwhereas\tO\nin\tO\nvincristine\tB-Chemical\n-\tO\ninduced\tO\nhyperalgesia\tB-Disease\nbradykinin\tB-Chemical\nseemed\tO\nto\tO\nactivate\tO\nneuronal\tO\nNO\tB-Chemical\nsynthase\tO\npathway\tO\n.\tO\n\nTherefore\tO\n,\tO\nconcomitant\tO\nadministration\tO\nof\tO\nsmall\tO\ndoses\tO\nof\tO\nbradykinin\tB-Chemical\nreceptor\tO\nantagonists\tO\nand\tO\nNO\tB-Chemical\nsynthase\tO\ninhibitors\tO\ncan\tO\nbe\tO\neffective\tO\nin\tO\nalleviation\tO\nof\tO\nneuropathic\tB-Disease\npain\tI-Disease\n,\tO\neven\tO\nin\tO\nhospital\tO\ncare\tO\n.\tO\n\nConfusion\tB-Disease\n,\tO\na\tO\nrather\tO\nserious\tO\nadverse\tO\ndrug\tO\nreaction\tO\nwith\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n:\tO\na\tO\nreview\tO\nof\tO\nthe\tO\nFrench\tO\nPharmacovigilance\tO\ndatabase\tO\n.\tO\n\nINTRODUCTION\tO\n:\tO\nConfusion\tB-Disease\nis\tO\nan\tO\nadverse\tO\ndrug\tO\nreaction\tO\nfrequently\tO\nobserved\tO\nwith\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nSome\tO\ncase\tO\nreports\tO\nare\tO\npublished\tO\nin\tO\nthe\tO\nliterature\tO\nbut\tO\nno\tO\nsystematic\tO\nstudy\tO\nfrom\tO\na\tO\nsample\tO\nof\tO\npatients\tO\nhas\tO\nbeen\tO\npublished\tO\n.\tO\n\nWe\tO\nperformed\tO\nthis\tO\nstudy\tO\nin\tO\norder\tO\nto\tO\ndescribe\tO\nthe\tO\nmain\tO\ncharacteristics\tO\nof\tO\nthis\tO\nadverse\tO\ndrug\tO\nreaction\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nthe\tO\nFrench\tO\nPharmacovigilance\tO\ndatabase\tO\n,\tO\nwe\tO\nselected\tO\nthe\tO\ncases\tO\nof\tO\nconfusion\tB-Disease\nreported\tO\nsince\tO\n1985\tO\nwith\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\n272\tO\ncases\tO\nof\tO\nconfusion\tB-Disease\nwere\tO\nreported\tO\nwith\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\n:\tO\n153\tO\nwomen\tO\nand\tO\n119\tO\nmen\tO\n.\tO\n\nConfusion\tB-Disease\nmostly\tO\noccurred\tO\nduring\tO\nthe\tO\ntwo\tO\nfirst\tO\nweeks\tO\nfollowing\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\nexposure\tO\n(\tO\n39\tO\n.\tO\n7\tO\n%\tO\n)\tO\n.\tO\n\nIt\tO\nwas\tO\n\"\tO\nserious\tO\n\"\tO\nfor\tO\nalmost\tO\n2\tO\n/\tO\n3\tO\nof\tO\nthe\tO\npatients\tO\n(\tO\n62\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\nits\tO\noutcome\tO\nfavourable\tO\nin\tO\nmost\tO\nof\tO\nthe\tO\ncases\tO\n(\tO\n82\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\noccurrence\tO\nof\tO\nthis\tO\nADR\tO\nwas\tO\nmore\tO\nfrequent\tO\nin\tO\npatients\tO\naged\tO\nbetween\tO\n61\tO\nand\tO\n80\tO\nyears\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nwork\tO\nshows\tO\nthat\tO\nconfusion\tB-Disease\nwith\tO\nvalproic\tB-Chemical\nacid\tI-Chemical\nis\tO\na\tO\nserious\tO\n,\tO\nrather\tO\nfrequent\tO\nbut\tO\nreversible\tO\nadverse\tO\ndrug\tO\nreaction\tO\n.\tO\n\nIt\tO\noccurs\tO\nespecially\tO\nin\tO\nolder\tO\npatients\tO\nand\tO\nduring\tO\nthe\tO\nfirst\tO\ntwo\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nReversible\tO\ninferior\tB-Disease\ncolliculus\tI-Disease\nlesion\tI-Disease\nin\tO\nmetronidazole\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\n:\tO\nmagnetic\tO\nresonance\tO\nfindings\tO\non\tO\ndiffusion\tO\n-\tO\nweighted\tO\nand\tO\nfluid\tO\nattenuated\tO\ninversion\tO\nrecovery\tO\nimaging\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThis\tO\nis\tO\nto\tO\npresent\tO\nreversible\tO\ninferior\tB-Disease\ncolliculus\tI-Disease\nlesions\tI-Disease\nin\tO\nmetronidazole\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\n,\tO\nto\tO\nfocus\tO\non\tO\nthe\tO\ndiffusion\tO\n-\tO\nweighted\tO\nimaging\tO\n(\tO\nDWI\tO\n)\tO\nand\tO\nfluid\tO\nattenuated\tO\ninversion\tO\nrecovery\tO\n(\tO\nFLAIR\tO\n)\tO\nimaging\tO\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nFrom\tO\nNovember\tO\n2005\tO\nto\tO\nSeptember\tO\n2007\tO\n,\tO\n8\tO\npatients\tO\n(\tO\n5\tO\nmen\tO\nand\tO\n3\tO\nwomen\tO\n)\tO\nwere\tO\ndiagnosed\tO\nas\tO\nhaving\tO\nmetronidazole\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\n(\tO\nage\tO\nrange\tO\n;\tO\n43\tO\n-\tO\n78\tO\nyears\tO\n)\tO\n.\tO\n\nThey\tO\nhad\tO\nbeen\tO\ntaking\tO\nmetronidazole\tB-Chemical\n(\tO\ntotal\tO\ndosage\tO\n,\tO\n45\tO\n-\tO\n120\tO\ng\tO\n;\tO\nduration\tO\n,\tO\n30\tO\ndays\tO\nto\tO\n2\tO\nmonths\tO\n)\tO\nto\tO\ntreat\tO\nthe\tO\ninfection\tB-Disease\nin\tO\nvarious\tO\norgans\tO\n.\tO\n\nInitial\tO\nbrain\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n(\tO\nMRI\tO\n)\tO\nwere\tO\nobtained\tO\nafter\tO\nthe\tO\nhospitalization\tO\n,\tO\nincluding\tO\nDWI\tO\n(\tO\n8\tO\n/\tO\n8\tO\n)\tO\n,\tO\napparent\tO\ndiffusion\tO\ncoefficient\tO\n(\tO\nADC\tO\n)\tO\nmap\tO\n(\tO\n4\tO\n/\tO\n8\tO\n)\tO\n,\tO\nFLAIR\tO\n(\tO\n7\tO\n/\tO\n8\tO\n)\tO\n,\tO\nand\tO\nT2\tO\n-\tO\nweighted\tO\nimage\tO\n(\tO\n8\tO\n/\tO\n8\tO\n)\tO\n.\tO\n\nFollow\tO\n-\tO\nup\tO\nMRIs\tO\nwere\tO\nperformed\tO\non\tO\n5\tO\npatients\tO\nfrom\tO\nthird\tO\nto\tO\n14th\tO\ndays\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nmetronidazole\tB-Chemical\nadministration\tO\n.\tO\n\nFindings\tO\nof\tO\ninitial\tO\nand\tO\nfollow\tO\n-\tO\nup\tO\nMRIs\tO\nwere\tO\nretrospectively\tO\nevaluated\tO\nby\tO\n2\tO\nneuroradiologists\tO\nby\tO\nconsensus\tO\n,\tO\nto\tO\nanalyze\tO\nthe\tO\npresence\tO\nof\tO\nabnormal\tO\nsignal\tO\nintensities\tO\n,\tO\ntheir\tO\nlocations\tO\n,\tO\nand\tO\nsignal\tO\nchanges\tO\non\tO\nfollow\tO\n-\tO\nup\tO\nimages\tO\n.\tO\n\nRESULTS\tO\n:\tO\nInitial\tO\nMRIs\tO\nshowed\tO\nabnormal\tO\nhigh\tO\nsignal\tO\nintensities\tO\non\tO\nDWI\tO\nand\tO\nFLAIR\tO\n(\tO\nor\tO\nT2\tO\n-\tO\nweighted\tO\nimage\tO\n)\tO\nat\tO\nthe\tO\ndentate\tO\nnucleus\tO\n(\tO\n8\tO\n/\tO\n8\tO\n)\tO\n,\tO\ninferior\tO\ncolliculus\tO\n(\tO\n6\tO\n/\tO\n8\tO\n)\tO\n,\tO\ncorpus\tO\ncallosum\tO\n(\tO\n2\tO\n/\tO\n8\tO\n)\tO\n,\tO\npons\tO\n(\tO\n2\tO\n/\tO\n8\tO\n)\tO\n,\tO\nmedulla\tO\n(\tO\n1\tO\n/\tO\n8\tO\n)\tO\n,\tO\nand\tO\nbilateral\tO\ncerebral\tO\nwhite\tO\nmatter\tO\n(\tO\n1\tO\n/\tO\n8\tO\n)\tO\n.\tO\n\nHigh\tO\n-\tO\nsignal\tO\nintensity\tO\nlesions\tO\non\tO\nDWI\tO\ntended\tO\nto\tO\nshow\tO\nlow\tO\nsignal\tO\nintensity\tO\non\tO\nADC\tO\nmap\tO\n(\tO\n3\tO\n/\tO\n4\tO\n)\tO\n,\tO\nbut\tO\nin\tO\none\tO\npatient\tO\n,\tO\nhigh\tO\nsignal\tO\nintensity\tO\nwas\tO\nshown\tO\nat\tO\nbilateral\tO\ndentate\tO\nnuclei\tO\non\tO\nnot\tO\nonly\tO\nDWI\tO\nbut\tO\nalso\tO\nADC\tO\nmap\tO\n.\tO\n\nAll\tO\nthe\tO\nlesions\tO\nin\tO\ndentate\tO\n,\tO\ninferior\tO\ncolliculus\tO\n,\tO\npons\tO\n,\tO\nand\tO\nmedullas\tO\nhad\tO\nbeen\tO\nresolved\tO\ncompletely\tO\non\tO\nfollow\tO\n-\tO\nup\tO\nMRIs\tO\nin\tO\n5\tO\npatients\tO\n,\tO\nbut\tO\nin\tO\n1\tO\npatient\tO\nof\tO\nthem\tO\n,\tO\ncorpus\tO\ncallosal\tB-Disease\nlesion\tI-Disease\npersisted\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nReversible\tO\ninferior\tB-Disease\ncolliculus\tI-Disease\nlesions\tI-Disease\ncould\tO\nbe\tO\nconsidered\tO\nas\tO\nthe\tO\ncharacteristic\tO\nfor\tO\nmetronidazole\tB-Chemical\n-\tO\ninduced\tO\nencephalopathy\tB-Disease\n,\tO\nnext\tO\nto\tO\nthe\tO\ndentate\tO\nnucleus\tO\ninvolvement\tO\n.\tO\n\nClinically\tO\nsignificant\tO\nproteinuria\tB-Disease\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nsirolimus\tB-Chemical\nto\tO\nrenal\tO\ntransplant\tO\nrecipients\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nSirolimus\tB-Chemical\nis\tO\nthe\tO\nlatest\tO\nimmunosuppressive\tO\nagent\tO\nused\tO\nto\tO\nprevent\tO\nrejection\tO\n,\tO\nand\tO\nmay\tO\nhave\tO\nless\tO\nnephrotoxicity\tB-Disease\nthan\tO\ncalcineurin\tO\ninhibitor\tO\n(\tO\nCNI\tO\n)\tO\n-\tO\nbased\tO\nregimens\tO\n.\tO\n\nTo\tO\ndate\tO\nthere\tO\nhas\tO\nbeen\tO\nlittle\tO\ndocumentation\tO\nof\tO\nclinically\tO\nsignificant\tO\nproteinuria\tB-Disease\nlinked\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nsirolimus\tB-Chemical\n.\tO\n\nWe\tO\nhave\tO\nencountered\tO\nseveral\tO\npatients\tO\nwho\tO\ndeveloped\tO\nsubstantial\tO\nproteinuria\tB-Disease\nassociated\tO\nwith\tO\nsirolimus\tB-Chemical\nuse\tO\n.\tO\n\nIn\tO\neach\tO\npatient\tO\n,\tO\nthe\tO\nclose\tO\ntemporal\tO\nassociation\tO\nbetween\tO\nthe\tO\ncommencement\tO\nof\tO\nsirolimus\tB-Chemical\ntherapy\tO\nand\tO\nproteinuria\tB-Disease\nimplicated\tO\nsirolimus\tB-Chemical\nas\tO\nthe\tO\nmost\tO\nlikely\tO\netiology\tO\nof\tO\nthe\tO\nproteinuria\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nanalyzed\tO\nthe\tO\nclinical\tO\nand\tO\nlaboratory\tO\ninformation\tO\navailable\tO\nfor\tO\nall\tO\n119\tO\npatients\tO\ntransplanted\tO\nat\tO\nthe\tO\nWashington\tO\nHospital\tO\nCenter\tO\nbetween\tO\n1999\tO\n-\tO\n2003\tO\nfor\tO\nwhom\tO\nsirolimus\tB-Chemical\nwas\tO\na\tO\ncomponent\tO\nof\tO\ntheir\tO\nimmunosuppressant\tO\nregimen\tO\n.\tO\n\nIn\tO\nthese\tO\npatients\tO\n,\tO\nthe\tO\nmagnitude\tO\nof\tO\nproteinuria\tB-Disease\nwas\tO\nassessed\tO\non\tO\nmorning\tO\nurine\tO\nsamples\tO\nby\tO\nturbidometric\tO\nmeasurement\tO\nor\tO\nrandom\tO\nurine\tO\nprotein\tO\n:\tO\ncreatinine\tB-Chemical\nratios\tO\n,\tO\nan\tO\nestimate\tO\nof\tO\ngrams\tO\nof\tO\nproteinuria\tB-Disease\n/\tO\nday\tO\n.\tO\n\nLaboratory\tO\nresults\tO\nwere\tO\ncompared\tO\nbetween\tO\nprior\tO\n,\tO\nduring\tO\nand\tO\nfollowing\tO\nsirolimus\tB-Chemical\nuse\tO\n.\tO\n\nRESULTS\tO\n:\tO\nTwenty\tO\n-\tO\neight\tO\npatients\tO\n(\tO\n24\tO\n%\tO\n)\tO\ndeveloped\tO\nincreased\tO\nproteinuria\tB-Disease\nfrom\tO\nbaseline\tO\nduring\tO\ntheir\tO\npost\tO\n-\tO\ntransplantation\tO\ncourse\tO\n.\tO\n\nIn\tO\n21\tO\npatients\tO\nan\tO\nalternative\tO\ncause\tO\nof\tO\nproteinuria\tB-Disease\nwas\tO\neither\tO\nobvious\tO\nor\tO\ninsufficient\tO\ndata\tO\nwas\tO\navailable\tO\nto\tO\nbe\tO\nconclusive\tO\n.\tO\n\nIn\tO\n7\tO\nof\tO\nthe\tO\n28\tO\npatients\tO\nthere\tO\nwas\tO\na\tO\nstriking\tO\ntemporal\tO\nassociation\tO\nbetween\tO\nthe\tO\ninitiation\tO\nof\tO\nsirolimus\tB-Chemical\nand\tO\nthe\tO\ndevelopment\tO\nof\tO\nnephrotic\tB-Disease\n-\tO\nrange\tO\nproteinuria\tB-Disease\n.\tO\n\nProteinuria\tB-Disease\ncorrelated\tO\nmost\tO\nstrongly\tO\nwith\tO\nsirolimus\tB-Chemical\ntherapy\tO\nwhen\tO\ncompared\tO\nto\tO\nother\tO\ndemographic\tO\nand\tO\nclinical\tO\nvariables\tO\n.\tO\n\nIn\tO\nmost\tO\npatients\tO\n,\tO\ndiscontinuation\tO\nof\tO\nsirolimus\tB-Chemical\nresulted\tO\nin\tO\na\tO\ndecrease\tO\n,\tO\nbut\tO\nnot\tO\nresolution\tO\n,\tO\nof\tO\nproteinuria\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSirolimus\tB-Chemical\ninduces\tO\nor\tO\naggravates\tO\npre\tO\n-\tO\nexisting\tO\nproteinuria\tB-Disease\nin\tO\nan\tO\nunpredictable\tO\nsubset\tO\nof\tO\nrenal\tO\nallograft\tO\nrecipients\tO\n.\tO\n\nProteinuria\tB-Disease\nmay\tO\nimprove\tO\n,\tO\nbut\tO\ndoes\tO\nnot\tO\nresolve\tO\n,\tO\nwhen\tO\nsirolimus\tB-Chemical\nis\tO\nwithdrawn\tO\n.\tO\n\nComponents\tO\nof\tO\nlemon\tO\nessential\tO\noil\tO\nattenuate\tO\ndementia\tB-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\n.\tO\n\nThe\tO\nanti\tO\n-\tO\ndementia\tB-Disease\neffects\tO\nof\tO\ns\tB-Chemical\n-\tI-Chemical\nlimonene\tI-Chemical\nand\tO\ns\tB-Chemical\n-\tI-Chemical\nperillyl\tI-Chemical\nalcohol\tI-Chemical\nwere\tO\nobserved\tO\nusing\tO\nthe\tO\npassive\tO\navoidance\tO\ntest\tO\n(\tO\nPA\tO\n)\tO\nand\tO\nthe\tO\nopen\tO\nfield\tO\nhabituation\tO\ntest\tO\n(\tO\nOFH\tO\n)\tO\n.\tO\n\nThese\tO\nlemon\tO\nessential\tO\noils\tO\nshowed\tO\nstrong\tO\nability\tO\nto\tO\nimprove\tO\nmemory\tB-Disease\nimpaired\tI-Disease\nby\tO\nscopolamine\tB-Chemical\n;\tO\nhowever\tO\n,\tO\ns\tB-Chemical\n-\tI-Chemical\nperillyl\tI-Chemical\nalcohol\tI-Chemical\nrelieved\tO\nthe\tO\ndeficit\tB-Disease\nof\tI-Disease\nassociative\tI-Disease\nmemory\tI-Disease\nin\tO\nPA\tO\nonly\tO\n,\tO\nand\tO\ndid\tO\nnot\tO\nimprove\tO\nnon\tO\n-\tO\nassociative\tO\nmemory\tO\nsignificantly\tO\nin\tO\nOFH\tO\n.\tO\n\nAnalysis\tO\nof\tO\nneurotransmitter\tO\nconcentration\tO\nin\tO\nsome\tO\nbrain\tO\nregions\tO\non\tO\nthe\tO\ntest\tO\nday\tO\nshowed\tO\nthat\tO\ndopamine\tB-Chemical\nconcentration\tO\nof\tO\nthe\tO\nvehicle\tO\n/\tO\nscopolamine\tB-Chemical\ngroup\tO\nwas\tO\nsignificantly\tO\nlower\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\nvehicle\tO\n/\tO\nvehicle\tO\ngroup\tO\n,\tO\nbut\tO\nthis\tO\nphenomenon\tO\nwas\tO\nreversed\tO\nwhen\tO\ns\tB-Chemical\n-\tI-Chemical\nlimonene\tI-Chemical\nor\tO\ns\tB-Chemical\n-\tI-Chemical\nperillyl\tI-Chemical\nalcohol\tI-Chemical\nwere\tO\nadministered\tO\nbefore\tO\nthe\tO\ninjection\tO\nof\tO\nscopolamine\tB-Chemical\n.\tO\n\nSimultaneously\tO\n,\tO\nwe\tO\nfound\tO\nthat\tO\nthese\tO\ntwo\tO\nlemon\tO\nessential\tO\noil\tO\ncomponents\tO\ncould\tO\ninhibit\tO\nacetylcholinesterase\tO\nactivity\tO\nin\tO\nvitro\tO\nusing\tO\nthe\tO\nEllman\tO\nmethod\tO\n.\tO\n\nAttentional\tO\nmodulation\tO\nof\tO\nperceived\tO\npain\tB-Disease\nintensity\tO\nin\tO\ncapsaicin\tB-Chemical\n-\tO\ninduced\tO\nsecondary\tO\nhyperalgesia\tB-Disease\n.\tO\n\nPerceived\tO\npain\tB-Disease\nintensity\tO\nis\tO\nmodulated\tO\nby\tO\nattention\tO\n.\tO\n\nHowever\tO\n,\tO\nit\tO\nis\tO\nnot\tO\nknown\tO\nthat\tO\nhow\tO\npain\tB-Disease\nintensity\tO\nratings\tO\nare\tO\naffected\tO\nby\tO\nattention\tO\nin\tO\ncapsaicin\tB-Chemical\n-\tO\ninduced\tO\nsecondary\tO\nhyperalgesia\tB-Disease\n.\tO\n\nHere\tO\nwe\tO\nshow\tO\nthat\tO\nperceived\tO\npain\tB-Disease\nintensity\tO\nin\tO\nsecondary\tO\nhyperalgesia\tB-Disease\nis\tO\ndecreased\tO\nwhen\tO\nattention\tO\nis\tO\ndistracted\tO\naway\tO\nfrom\tO\nthe\tO\npainful\tO\npinprick\tO\nstimulus\tO\nwith\tO\na\tO\nvisual\tO\ntask\tO\n.\tO\n\nFurthermore\tO\n,\tO\nit\tO\nwas\tO\nfound\tO\nthat\tO\nthe\tO\nmagnitude\tO\nof\tO\nattentional\tO\nmodulation\tO\nin\tO\nsecondary\tO\nhyperalgesia\tB-Disease\nis\tO\nvery\tO\nsimilar\tO\nto\tO\nthat\tO\nof\tO\ncapsaicin\tB-Chemical\n-\tO\nuntreated\tO\n,\tO\ncontrol\tO\ncondition\tO\n.\tO\n\nOur\tO\nfindings\tO\n,\tO\nshowing\tO\nno\tO\ninteraction\tO\nbetween\tO\ncapsaicin\tB-Chemical\ntreatment\tO\nand\tO\nattentional\tO\nmodulation\tO\nsuggest\tO\nthat\tO\ncapsaicin\tB-Chemical\n-\tO\ninduced\tO\nsecondary\tO\nhyperalgesia\tB-Disease\nand\tO\nattention\tO\nmight\tO\naffect\tO\nmechanical\tO\npain\tB-Disease\nthrough\tO\nindependent\tO\nmechanisms\tO\n.\tO\n\nCardioprotective\tO\neffect\tO\nof\tO\nsalvianolic\tB-Chemical\nacid\tI-Chemical\nA\tI-Chemical\non\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\nthe\tO\ncardioprotective\tO\npotential\tO\nof\tO\nsalvianolic\tB-Chemical\nacid\tI-Chemical\nA\tI-Chemical\non\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nHemodynamic\tO\nparameters\tO\nand\tO\nlead\tO\nII\tO\nelectrocardiograph\tO\nwere\tO\nmonitored\tO\nand\tO\nrecorded\tO\ncontinuously\tO\n.\tO\n\nCardiac\tO\nmarker\tO\nenzymes\tO\nand\tO\nantioxidative\tO\nparameters\tO\nin\tO\nserum\tO\nand\tO\nheart\tO\ntissues\tO\nwere\tO\nmeasured\tO\n.\tO\n\nAssay\tO\nfor\tO\nmitochondrial\tO\nrespiratory\tO\nfunction\tO\nand\tO\nhistopathological\tO\nexamination\tO\nof\tO\nheart\tO\ntissues\tO\nwere\tO\nperformed\tO\n.\tO\n\nIsoproterenol\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nshowed\tO\nsignificant\tO\nincreases\tO\nin\tO\nthe\tO\nlevels\tO\nof\tO\nlactate\tB-Chemical\ndehydrogenase\tO\n,\tO\naspartate\tB-Chemical\ntransaminase\tO\n,\tO\ncreatine\tB-Chemical\nkinase\tO\nand\tO\nmalondialdehyde\tB-Chemical\nand\tO\nsignificant\tO\ndecreases\tO\nin\tO\nthe\tO\nactivities\tO\nof\tO\nsuperoxide\tB-Chemical\ndismutase\tO\n,\tO\ncatalase\tO\nand\tO\nglutathione\tB-Chemical\nperoxidase\tO\nin\tO\nserum\tO\nand\tO\nheart\tO\n.\tO\n\nThese\tO\nrats\tO\nalso\tO\nshowed\tO\ndeclines\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\n,\tO\nmaximum\tO\nand\tO\nminimum\tO\nrate\tO\nof\tO\ndeveloped\tO\nleft\tO\nventricular\tO\npressure\tO\n,\tO\nand\tO\nelevation\tO\nof\tO\nleft\tO\nventricular\tO\nend\tO\n-\tO\ndiastolic\tO\npressure\tO\nand\tO\nST\tO\n-\tO\nsegment\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nmitochondrial\tO\nrespiratory\tB-Disease\ndysfunction\tI-Disease\ncharacterized\tO\nby\tO\ndecreased\tO\nrespiratory\tO\ncontrol\tO\nratio\tO\nand\tO\nADP\tB-Chemical\n/\tO\nO\tO\nwas\tO\nobserved\tO\nin\tO\nisoproterenol\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nAdministration\tO\nof\tO\nsalvianolic\tB-Chemical\nacid\tI-Chemical\nA\tI-Chemical\nfor\tO\na\tO\nperiod\tO\nof\tO\n8\tO\ndays\tO\nsignificantly\tO\nattenuated\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\nand\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\nand\tO\nimproved\tO\nmitochondrial\tO\nrespiratory\tO\nfunction\tO\n.\tO\n\nThe\tO\nprotective\tO\nrole\tO\nof\tO\nsalvianolic\tB-Chemical\nacid\tI-Chemical\nA\tI-Chemical\nagainst\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nwas\tO\nfurther\tO\nconfirmed\tO\nby\tO\nhistopathological\tO\nexamination\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nour\tO\nstudy\tO\nsuggest\tO\nthat\tO\nsalvianolic\tB-Chemical\nacid\tI-Chemical\nA\tI-Chemical\npossessing\tO\nantioxidant\tO\nactivity\tO\nhas\tO\na\tO\nsignificant\tO\nprotective\tO\neffect\tO\nagainst\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nglutamate\tB-Chemical\nsupplementation\tO\nfailed\tO\nto\tO\nprotect\tO\nagainst\tO\nperipheral\tB-Disease\nneurotoxicity\tI-Disease\nof\tO\npaclitaxel\tB-Chemical\n.\tO\n\nToxic\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\nis\tO\nstill\tO\na\tO\nsignificant\tO\nlimiting\tO\nfactor\tO\nfor\tO\nchemotherapy\tO\nwith\tO\npaclitaxel\tB-Chemical\n(\tO\nPAC\tB-Chemical\n)\tO\n,\tO\nalthough\tO\nglutamate\tB-Chemical\nand\tO\nits\tO\nclosely\tO\nrelated\tO\namino\tB-Chemical\nacid\tI-Chemical\nglutamine\tB-Chemical\nwere\tO\nclaimed\tO\nto\tO\nameliorate\tO\nPAC\tB-Chemical\nneurotoxicity\tB-Disease\n.\tO\n\nThis\tO\npilot\tO\ntrial\tO\naimed\tO\nto\tO\nevaluate\tO\nthe\tO\nrole\tO\nof\tO\nglutamate\tB-Chemical\nsupplementation\tO\nfor\tO\npreventing\tO\nPAC\tB-Chemical\n-\tO\ninduced\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\nin\tO\na\tO\nrandomized\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\n,\tO\ndouble\tO\n-\tO\nblinded\tO\nclinical\tO\nand\tO\nelectro\tO\n-\tO\ndiagnostic\tO\nstudy\tO\n.\tO\n\nForty\tO\n-\tO\nthree\tO\novarian\tB-Disease\ncancer\tI-Disease\npatients\tO\nwere\tO\navailable\tO\nfor\tO\nanalysis\tO\nfollowing\tO\nsix\tO\ncycles\tO\nof\tO\nthe\tO\nsame\tO\nPAC\tB-Chemical\n-\tO\ncontaining\tO\nregimen\tO\n:\tO\n23\tO\nhad\tO\nbeen\tO\nsupplemented\tO\nby\tO\nglutamate\tB-Chemical\nall\tO\nalong\tO\nthe\tO\ntreatment\tO\nperiod\tO\n,\tO\nat\tO\na\tO\ndaily\tO\ndose\tO\nof\tO\nthree\tO\ntimes\tO\n500\tO\nmg\tO\n(\tO\ngroup\tO\nG\tO\n)\tO\n,\tO\nand\tO\n20\tO\nhad\tO\nreceived\tO\na\tO\nplacebo\tO\n(\tO\ngroup\tO\nP\tO\n)\tO\n.\tO\n\nPatients\tO\nwere\tO\nevaluated\tO\nby\tO\nneurological\tO\nexaminations\tO\n,\tO\nquestionnaires\tO\nand\tO\nsensory\tO\n-\tO\nmotor\tO\nnerve\tO\nconduction\tO\nstudies\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nsignificant\tO\ndifference\tO\nin\tO\nthe\tO\nfrequency\tO\nof\tO\nsigns\tO\nor\tO\nsymptoms\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\nalthough\tO\nneurotoxicity\tB-Disease\nsymptoms\tO\npresented\tO\nmostly\tO\nwith\tO\nlower\tO\nscores\tO\nof\tO\nseverity\tO\nin\tO\ngroup\tO\nG\tO\n.\tO\n\nHowever\tO\n,\tO\nthis\tO\ndifference\tO\nreached\tO\nstatistical\tO\nsignificance\tO\nonly\tO\nwith\tO\nregard\tO\nto\tO\nreported\tO\npain\tB-Disease\nsensation\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n011\tO\n)\tO\n.\tO\n\nAlso\tO\nthe\tO\nfrequency\tO\nof\tO\nabnormal\tO\nelectro\tO\n-\tO\ndiagnostic\tO\nfindings\tO\nshowed\tO\nsimilarity\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n(\tO\nG\tO\n:\tO\n7\tO\n/\tO\n23\tO\n=\tO\n30\tO\n.\tO\n4\tO\n%\tO\n;\tO\nP\tO\n:\tO\n6\tO\n/\tO\n20\tO\n=\tO\n30\tO\n%\tO\n)\tO\n.\tO\n\nThis\tO\npilot\tO\nstudy\tO\nleads\tO\nto\tO\nthe\tO\nconclusion\tO\nthat\tO\nglutamate\tB-Chemical\nsupplementation\tO\nat\tO\nthe\tO\nchosen\tO\nregimen\tO\nfails\tO\nto\tO\nprotect\tO\nagainst\tO\nperipheral\tB-Disease\nneurotoxicity\tI-Disease\nof\tO\nPAC\tB-Chemical\n.\tO\n\nDevelopment\tO\nof\tO\nocular\tB-Disease\nmyasthenia\tI-Disease\nduring\tO\npegylated\tB-Chemical\ninterferon\tI-Chemical\nand\tO\nribavirin\tB-Chemical\ntreatment\tO\nfor\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nC\tI-Disease\n.\tO\n\nA\tO\n63\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\nexperienced\tO\nsudden\tO\ndiplopia\tB-Disease\nafter\tO\n9\tO\nweeks\tO\nof\tO\nadministration\tO\nof\tO\npegylated\tB-Chemical\ninterferon\tI-Chemical\n(\tI-Chemical\nIFN\tI-Chemical\n)\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\n2b\tI-Chemical\nand\tO\nribavirin\tB-Chemical\nfor\tO\nchronic\tB-Disease\nhepatitis\tI-Disease\nC\tI-Disease\n(\tO\nCHC\tB-Disease\n)\tO\n.\tO\n\nOphthalmologic\tO\nexaminations\tO\nshowed\tO\nptosis\tB-Disease\non\tI-Disease\nthe\tI-Disease\nright\tI-Disease\nupper\tI-Disease\nlid\tI-Disease\nand\tO\nrestricted\tB-Disease\nright\tI-Disease\neye\tI-Disease\nmovement\tI-Disease\nwithout\tO\nany\tO\nother\tO\nneurological\tO\nsigns\tO\n.\tO\n\nA\tO\nbrain\tO\nimaging\tO\nstudy\tO\nand\tO\nrepetitive\tO\nnerve\tO\nstimulation\tO\ntest\tO\nindicated\tO\nno\tO\nabnormality\tO\n.\tO\n\nThe\tO\nacetylcholine\tB-Chemical\nreceptor\tO\nantibody\tO\ntiter\tO\nand\tO\nresponse\tO\nto\tO\nacetylcholinesterase\tO\ninhibitors\tO\nwere\tO\nnegative\tO\n,\tO\nand\tO\nthe\tO\nresults\tO\nof\tO\nthyroid\tO\nfunction\tO\ntests\tO\nwere\tO\nnormal\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nophthalmological\tO\nsymptoms\tO\nimproved\tO\nrapidly\tO\n3\tO\nweeks\tO\nafter\tO\ndiscontinuation\tO\nof\tO\npegylated\tB-Chemical\nIFN\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\n2b\tI-Chemical\nand\tO\nribavirin\tB-Chemical\n.\tO\n\nThe\tO\nocular\tB-Disease\nmyasthenia\tI-Disease\nassociated\tO\nwith\tO\ncombination\tO\ntherapy\tO\nof\tO\npegylated\tB-Chemical\nIFN\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\n2b\tI-Chemical\nand\tO\nribavirin\tB-Chemical\nfor\tO\nCHC\tB-Disease\nis\tO\nvery\tO\nrarely\tO\nreported\tO\n;\tO\ntherefore\tO\n,\tO\nwe\tO\npresent\tO\nthis\tO\ncase\tO\nwith\tO\na\tO\nreview\tO\nof\tO\nthe\tO\nvarious\tO\neye\tO\ncomplications\tO\nof\tO\nIFN\tB-Chemical\ntherapy\tO\n.\tO\n\nLearning\tB-Disease\nand\tI-Disease\nmemory\tI-Disease\ndeficits\tI-Disease\nin\tO\necstasy\tB-Chemical\nusers\tO\nand\tO\ntheir\tO\nneural\tO\ncorrelates\tO\nduring\tO\na\tO\nface\tO\n-\tO\nlearning\tO\ntask\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nconsistently\tO\nshown\tO\nthat\tO\necstasy\tB-Chemical\nusers\tO\ndisplay\tO\nimpairments\tB-Disease\nin\tI-Disease\nlearning\tI-Disease\nand\tI-Disease\nmemory\tI-Disease\nperformance\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nworking\tO\nmemory\tO\nprocessing\tO\nin\tO\necstasy\tB-Chemical\nusers\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nneural\tO\nalterations\tO\nin\tO\nhippocampal\tO\nand\tO\n/\tO\nor\tO\ncortical\tO\nregions\tO\nas\tO\nmeasured\tO\nby\tO\nfunctional\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n(\tO\nfMRI\tO\n)\tO\n.\tO\n\nUsing\tO\nfunctional\tO\nimaging\tO\nand\tO\na\tO\nface\tO\n-\tO\nlearning\tO\ntask\tO\n,\tO\nwe\tO\ninvestigated\tO\nneural\tO\ncorrelates\tO\nof\tO\nencoding\tO\nand\tO\nrecalling\tO\nface\tO\n-\tO\nname\tO\nassociations\tO\nin\tO\n20\tO\nrecreational\tO\ndrug\tO\nusers\tO\nwhose\tO\npredominant\tO\ndrug\tO\nuse\tO\nwas\tO\necstasy\tB-Chemical\nand\tO\n20\tO\ncontrols\tO\n.\tO\n\nTo\tO\naddress\tO\nthe\tO\npotential\tO\nconfounding\tO\neffects\tO\nof\tO\nthe\tO\ncannabis\tB-Chemical\nuse\tO\nof\tO\nthe\tO\necstasy\tB-Chemical\nusing\tO\ngroup\tO\n,\tO\na\tO\nsecond\tO\nanalysis\tO\nincluded\tO\n14\tO\npreviously\tO\ntested\tO\ncannabis\tB-Chemical\nusers\tO\n(\tO\nNestor\tO\n,\tO\nL\tO\n.\tO\n,\tO\nRoberts\tO\n,\tO\nG\tO\n.\tO\n,\tO\nGaravan\tO\n,\tO\nH\tO\n.\tO\n,\tO\nHester\tO\n,\tO\nR\tO\n.\tO\n,\tO\n2008\tO\n.\tO\nDeficits\tB-Disease\nin\tI-Disease\nlearning\tI-Disease\nand\tI-Disease\nmemory\tI-Disease\n:\tO\nparahippocampal\tO\nhyperactivity\tB-Disease\nand\tO\nfrontocortical\tO\nhypoactivity\tO\nin\tO\ncannabis\tB-Chemical\nusers\tO\n.\tO\nNeuroimage\tO\n40\tO\n,\tO\n1328\tO\n-\tO\n1339\tO\n)\tO\n.\tO\n\nEcstasy\tB-Chemical\nusers\tO\nperformed\tO\nsignificantly\tO\nworse\tO\nin\tO\nlearning\tO\nand\tO\nmemory\tO\ncompared\tO\nto\tO\ncontrols\tO\nand\tO\ncannabis\tB-Chemical\nusers\tO\n.\tO\n\nA\tO\nconjunction\tO\nanalysis\tO\nof\tO\nthe\tO\nencode\tO\nand\tO\nrecall\tO\nphases\tO\nof\tO\nthe\tO\ntask\tO\nrevealed\tO\necstasy\tB-Chemical\n-\tO\nspecific\tO\nhyperactivity\tB-Disease\nin\tO\nbilateral\tO\nfrontal\tO\nregions\tO\n,\tO\nleft\tO\ntemporal\tO\n,\tO\nright\tO\nparietal\tO\n,\tO\nbilateral\tO\ntemporal\tO\n,\tO\nand\tO\nbilateral\tO\noccipital\tO\nbrain\tO\nregions\tO\n.\tO\n\nEcstasy\tB-Chemical\n-\tO\nspecific\tO\nhypoactivity\tO\nwas\tO\nevident\tO\nin\tO\nthe\tO\nright\tO\ndorsal\tO\nanterior\tO\ncingulated\tO\ncortex\tO\n(\tO\nACC\tO\n)\tO\nand\tO\nleft\tO\nposterior\tO\ncingulated\tO\ncortex\tO\n.\tO\n\nIn\tO\nboth\tO\necstasy\tB-Chemical\nand\tO\ncannabis\tB-Chemical\ngroups\tO\nbrain\tO\nactivation\tO\nwas\tO\ndecreased\tO\nin\tO\nthe\tO\nright\tO\nmedial\tO\nfrontal\tO\ngyrus\tO\n,\tO\nleft\tO\nparahippocampal\tO\ngyrus\tO\n,\tO\nleft\tO\ndorsal\tO\ncingulate\tO\ngyrus\tO\n,\tO\nand\tO\nleft\tO\ncaudate\tO\n.\tO\n\nThese\tO\nresults\tO\nelucidated\tO\necstasy\tB-Chemical\n-\tO\nrelated\tO\ndeficits\tO\n,\tO\nonly\tO\nsome\tO\nof\tO\nwhich\tO\nmight\tO\nbe\tO\nattributed\tO\nto\tO\ncannabis\tB-Chemical\nuse\tO\n.\tO\n\nThese\tO\necstasy\tB-Chemical\n-\tO\nspecific\tO\neffects\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nthe\tO\nvulnerability\tO\nof\tO\nisocortical\tO\nand\tO\nallocortical\tO\nregions\tO\nto\tO\nthe\tO\nneurotoxic\tB-Disease\neffects\tO\nof\tO\necstasy\tB-Chemical\n.\tO\n\nDisulfiram\tB-Chemical\n-\tO\nlike\tO\nsyndrome\tO\nafter\tO\nhydrogen\tB-Chemical\ncyanamide\tI-Chemical\nprofessional\tO\nskin\tO\nexposure\tO\n:\tO\ntwo\tO\ncase\tO\nreports\tO\nin\tO\nFrance\tO\n.\tO\n\nHydrogen\tB-Chemical\ncyanamide\tI-Chemical\nis\tO\na\tO\nplant\tO\ngrowth\tO\nregulator\tO\nused\tO\nin\tO\nagriculture\tO\nto\tO\ninduce\tO\nbud\tO\nbreak\tO\nin\tO\nfruit\tO\ntrees\tO\n.\tO\n\nContact\tO\nwith\tO\nthe\tO\nskin\tO\ncan\tO\nresult\tO\nin\tO\npercutaneous\tO\nabsorption\tO\nof\tO\nthe\tO\nsubstance\tO\nthat\tO\ninhibits\tO\naldehyde\tB-Chemical\ndehydrogenase\tO\nand\tO\ncan\tO\ninduce\tO\nacetaldehyde\tB-Chemical\nsyndrome\tO\nin\tO\ncase\tO\nof\tO\nalcohol\tB-Chemical\nuse\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nreport\tO\nis\tO\nto\tO\ndescribe\tO\ntwo\tO\ncases\tO\nof\tO\na\tO\ndisulfiram\tB-Chemical\n-\tO\nlike\tO\nsyndrome\tO\nfollowing\tO\noccupational\tO\nexposure\tO\nto\tO\nhydrogen\tB-Chemical\ncyanamide\tI-Chemical\n.\tO\n\nThe\tO\nfirst\tO\ncase\tO\ninvolved\tO\na\tO\n59\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\nused\tO\nDormex\tB-Chemical\n,\tO\nwhich\tO\ncontains\tO\nhydrogen\tB-Chemical\ncyanamide\tI-Chemical\n,\tO\nwithout\tO\nprotection\tO\nafter\tO\nconsuming\tO\na\tO\nlarge\tO\namount\tO\nof\tO\nalcohol\tB-Chemical\nduring\tO\na\tO\nmeal\tO\n.\tO\n\nIn\tO\nless\tO\nthan\tO\n1\tO\nhour\tO\nafter\tO\nthe\tO\ningestion\tO\nof\tO\nalcohol\tB-Chemical\n,\tO\nhe\tO\ndeveloped\tO\nmalaise\tO\nwith\tO\nflushing\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nface\tI-Disease\n,\tO\ntachycardia\tB-Disease\n,\tO\nand\tO\ndyspnea\tB-Disease\n.\tO\n\nManifestations\tO\nregressed\tO\nspontaneously\tO\nunder\tO\nsurveillance\tO\nin\tO\nthe\tO\nhospital\tO\n.\tO\n\nThe\tO\nsecond\tO\ncase\tO\noccurred\tO\nin\tO\na\tO\n55\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfarmer\tO\nfollowing\tO\ncutaneous\tO\ncontact\tO\nwith\tO\nDormex\tB-Chemical\n.\tO\n\nFive\tO\nhours\tO\nafter\tO\nexposure\tO\n,\tO\nhe\tO\ndeveloped\tO\ndisulfiram\tB-Chemical\n-\tO\nlike\tO\nsyndrome\tO\nwith\tO\nflushing\tB-Disease\n,\tO\ntachycardia\tB-Disease\n,\tO\nand\tO\narterial\tB-Disease\nhypotension\tI-Disease\nafter\tO\nconsuming\tO\nthree\tO\nglasses\tO\nof\tO\nwine\tO\n.\tO\n\nThe\tO\npatient\tO\nrecovered\tO\nspontaneously\tO\nin\tO\n3\tO\nhours\tO\nunder\tO\nsurveillance\tO\nin\tO\nthe\tO\nhospital\tO\n.\tO\n\nThese\tO\ncases\tO\nconfirm\tO\nthe\tO\nnecessity\tO\nof\tO\navoiding\tO\nalcohol\tB-Chemical\nconsumption\tO\nas\tO\nrecommended\tO\nin\tO\nthe\tO\ninstructions\tO\nfor\tO\nuse\tO\nof\tO\nDormex\tB-Chemical\nand\tO\nof\tO\npreventing\tO\ncutaneous\tO\ncontact\tO\nduring\tO\nuse\tO\n.\tO\n\nSulpiride\tB-Chemical\n-\tO\ninduced\tO\ntardive\tB-Disease\ndystonia\tI-Disease\n.\tO\n\nSulpiride\tB-Chemical\nis\tO\na\tO\nselective\tO\nD2\tO\n-\tO\nreceptor\tO\nantagonist\tO\nwith\tO\nantipsychotic\tO\nand\tO\nantidepressant\tB-Chemical\nproperties\tO\n.\tO\n\nAlthough\tO\ninitially\tO\nthought\tO\nto\tO\nbe\tO\nfree\tO\nof\tO\nextrapyramidal\tO\nside\tO\neffects\tO\n,\tO\nsulpiride\tB-Chemical\n-\tO\ninduced\tO\ntardive\tB-Disease\ndyskinesia\tI-Disease\nand\tO\nparkinsonism\tB-Disease\nhave\tO\nbeen\tO\nreported\tO\noccasionally\tO\n.\tO\n\nWe\tO\nstudied\tO\na\tO\n37\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\ndeveloped\tO\npersistent\tO\nsegmental\tO\ndystonia\tB-Disease\nwithin\tO\n2\tO\nmonths\tO\nafter\tO\nstarting\tO\nsulpiride\tB-Chemical\ntherapy\tO\n.\tO\n\nWe\tO\ncould\tO\nnot\tO\nfind\tO\nany\tO\nprevious\tO\nreports\tO\nof\tO\nsulpiride\tB-Chemical\n-\tO\ninduced\tO\ntardive\tB-Disease\ndystonia\tI-Disease\n.\tO\n\nComparative\tO\ncognitive\tO\nand\tO\nsubjective\tO\nside\tO\neffects\tO\nof\tO\nimmediate\tO\n-\tO\nrelease\tO\noxycodone\tB-Chemical\nin\tO\nhealthy\tO\nmiddle\tO\n-\tO\naged\tO\nand\tO\nolder\tO\nadults\tO\n.\tO\n\nThis\tO\nstudy\tO\nmeasured\tO\nthe\tO\nobjective\tO\nand\tO\nsubjective\tO\nneurocognitive\tO\neffects\tO\nof\tO\na\tO\nsingle\tO\n10\tO\n-\tO\nmg\tO\ndose\tO\nof\tO\nimmediate\tO\n-\tO\nrelease\tO\noxycodone\tB-Chemical\nin\tO\nhealthy\tO\n,\tO\nolder\tO\n(\tO\n>\tO\n65\tO\nyears\tO\n)\tO\n,\tO\nand\tO\nmiddle\tO\n-\tO\naged\tO\n(\tO\n35\tO\nto\tO\n55\tO\nyears\tO\n)\tO\nadults\tO\nwho\tO\nwere\tO\nnot\tO\nsuffering\tO\nfrom\tO\nchronic\tO\nor\tO\nsignificant\tO\ndaily\tO\npain\tB-Disease\n.\tO\n\nSeventy\tO\n-\tO\none\tO\nparticipants\tO\ncompleted\tO\n2\tO\nseparate\tO\nstudy\tO\ndays\tO\nand\tO\nwere\tO\nblind\tO\nto\tO\nmedication\tO\ncondition\tO\n(\tO\nplacebo\tO\n,\tO\n10\tO\n-\tO\nmg\tO\noxycodone\tB-Chemical\n)\tO\n.\tO\n\nPlasma\tO\noxycodone\tB-Chemical\nconcentration\tO\npeaked\tO\nbetween\tO\n60\tO\nand\tO\n90\tO\nminutes\tO\npostdose\tO\n(\tO\nP\tO\n<\tO\n.\tO\n01\tO\n)\tO\nand\tO\npupil\tO\nsize\tO\n,\tO\nan\tO\nindication\tO\nof\tO\nphysiological\tO\neffects\tO\nof\tO\nthe\tO\nmedication\tO\n,\tO\npeaked\tO\nat\tO\napproximately\tO\n90\tO\nto\tO\n120\tO\nminutes\tO\npostdose\tO\n(\tO\nP\tO\n<\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nSignificant\tO\ndeclines\tB-Disease\nin\tI-Disease\nsimple\tI-Disease\nand\tI-Disease\nsustained\tI-Disease\nattention\tI-Disease\n,\tI-Disease\nworking\tI-Disease\nmemory\tI-Disease\n,\tI-Disease\nand\tI-Disease\nverbal\tI-Disease\nmemory\tI-Disease\nwere\tO\nobserved\tO\nat\tO\n1\tO\nhour\tO\npostdose\tO\ncompared\tO\nto\tO\nbaseline\tO\nfor\tO\nboth\tO\nage\tO\ngroups\tO\nwith\tO\na\tO\ntrend\tO\ntoward\tO\nreturn\tO\nto\tO\nbaseline\tO\nby\tO\n5\tO\nhours\tO\npostdose\tO\n.\tO\n\nFor\tO\nalmost\tO\nall\tO\ncognitive\tO\nmeasures\tO\n,\tO\nthere\tO\nwere\tO\nno\tO\nmedication\tO\nby\tO\nage\tO\n-\tO\ninteraction\tO\neffects\tO\n,\tO\nwhich\tO\nindicates\tO\nthat\tO\nthe\tO\n2\tO\nage\tO\ngroups\tO\nexhibited\tO\nsimilar\tO\nresponses\tO\nto\tO\nthe\tO\nmedication\tO\nchallenge\tO\n.\tO\n\nThis\tO\nstudy\tO\nsuggests\tO\nthat\tO\nfor\tO\nhealthy\tO\nolder\tO\nadults\tO\nwho\tO\nare\tO\nnot\tO\nsuffering\tO\nfrom\tO\nchronic\tB-Disease\npain\tI-Disease\n,\tO\nneurocognitive\tO\nand\tO\npharmacodynamic\tO\nchanges\tO\nin\tO\nresponse\tO\nto\tO\na\tO\n10\tO\n-\tO\nmg\tO\ndose\tO\nof\tO\nimmediate\tO\n-\tO\nrelease\tO\noxycodone\tB-Chemical\nare\tO\nsimilar\tO\nto\tO\nthose\tO\nobserved\tO\nfor\tO\nmiddle\tO\n-\tO\naged\tO\nadults\tO\n.\tO\n\nPERSPECTIVE\tO\n:\tO\nStudy\tO\nfindings\tO\nindicate\tO\nthat\tO\nthe\tO\nmetabolism\tO\n,\tO\nneurocognitive\tO\neffects\tO\n,\tO\nand\tO\nphysical\tO\nside\tO\neffects\tO\nof\tO\noral\tO\noxycodone\tB-Chemical\nare\tO\nsimilar\tO\nfor\tO\nhealthy\tO\nmiddle\tO\n-\tO\naged\tO\nand\tO\nolder\tO\nadults\tO\n.\tO\n\nTherefore\tO\n,\tO\nclinicians\tO\nshould\tO\nnot\tO\navoid\tO\nprescribing\tO\noral\tO\nopioids\tO\nto\tO\nolder\tO\nadults\tO\nbased\tO\non\tO\nthe\tO\nbelief\tO\nthat\tO\nolder\tO\nadults\tO\nare\tO\nat\tO\nhigher\tO\nrisk\tO\nfor\tO\nside\tO\neffects\tO\nthan\tO\nyounger\tO\nadults\tO\n.\tO\n\nThe\tO\nglycine\tB-Chemical\ntransporter\tO\n-\tO\n1\tO\ninhibitor\tO\nSSR103800\tB-Chemical\ndisplays\tO\na\tO\nselective\tO\nand\tO\nspecific\tO\nantipsychotic\tO\n-\tO\nlike\tO\nprofile\tO\nin\tO\nnormal\tO\nand\tO\ntransgenic\tO\nmice\tO\n.\tO\n\nSchizophrenia\tB-Disease\nhas\tO\nbeen\tO\ninitially\tO\nassociated\tO\nwith\tO\ndysfunction\tO\nin\tO\ndopamine\tB-Chemical\nneurotransmission\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nobservation\tO\nthat\tO\nantagonists\tO\nof\tO\nthe\tO\nglutamate\tB-Chemical\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nreceptor\tO\nproduce\tO\nschizophrenic\tB-Disease\n-\tO\nlike\tO\nsymptoms\tO\nin\tO\nhumans\tO\nhas\tO\nled\tO\nto\tO\nthe\tO\nidea\tO\nof\tO\na\tO\ndysfunctioning\tO\nof\tO\nthe\tO\nglutamatergic\tO\nsystem\tO\nvia\tO\nits\tO\nNMDA\tB-Chemical\nreceptor\tO\n.\tO\n\nAs\tO\na\tO\nresult\tO\n,\tO\nthere\tO\nis\tO\na\tO\ngrowing\tO\ninterest\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\npharmacological\tO\nagents\tO\nwith\tO\npotential\tO\nantipsychotic\tO\nproperties\tO\nthat\tO\nenhance\tO\nthe\tO\nactivity\tO\nof\tO\nthe\tO\nglutamatergic\tO\nsystem\tO\nvia\tO\na\tO\nmodulation\tO\nof\tO\nthe\tO\nNMDA\tB-Chemical\nreceptor\tO\n.\tO\n\nAmong\tO\nthem\tO\nare\tO\nglycine\tB-Chemical\ntransporter\tO\n-\tO\n1\tO\n(\tO\nGlyT1\tO\n)\tO\ninhibitors\tO\nsuch\tO\nas\tO\nSSR103800\tB-Chemical\n,\tO\nwhich\tO\nindirectly\tO\nenhance\tO\nNMDA\tB-Chemical\nreceptor\tO\nfunction\tO\nby\tO\nincreasing\tO\nthe\tO\nglycine\tB-Chemical\n(\tO\na\tO\nco\tO\n-\tO\nagonist\tO\nfor\tO\nthe\tO\nNMDA\tB-Chemical\nreceptor\tO\n)\tO\nlevels\tO\nin\tO\nthe\tO\nsynapse\tO\n.\tO\n\nThis\tO\nstudy\tO\naimed\tO\nat\tO\ninvestigating\tO\nthe\tO\npotential\tO\nantipsychotic\tO\n-\tO\nlike\tO\nproperties\tO\nof\tO\nSSR103800\tB-Chemical\n,\tO\nwith\tO\na\tO\nparticular\tO\nfocus\tO\non\tO\nmodels\tO\nof\tO\nhyperactivity\tB-Disease\n,\tO\ninvolving\tO\neither\tO\ndrug\tO\nchallenge\tO\n(\tO\nie\tO\n,\tO\namphetamine\tB-Chemical\nand\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\n)\tO\nor\tO\ntransgenic\tO\nmice\tO\n(\tO\nie\tO\n,\tO\nNMDA\tB-Chemical\nNr1\tO\n(\tO\nneo\tO\n-\tO\n/\tO\n-\tO\n)\tO\nand\tO\nDAT\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\n)\tO\n.\tO\n\nResults\tO\nshowed\tO\nthat\tO\nSSR103800\tB-Chemical\n(\tO\n10\tO\n-\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\nblocked\tO\nhyperactivity\tB-Disease\ninduced\tO\nby\tO\nthe\tO\nnon\tO\n-\tO\ncompetitive\tO\nNMDA\tB-Chemical\nreceptor\tO\nantagonist\tO\n,\tO\nMK\tB-Chemical\n-\tI-Chemical\n801\tI-Chemical\nand\tO\npartially\tO\nreversed\tO\nspontaneous\tO\nhyperactivity\tB-Disease\nof\tO\nNMDA\tB-Chemical\nNr1\tO\n(\tO\nneo\tO\n-\tO\n/\tO\n-\tO\n)\tO\nmice\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nSSR103800\tB-Chemical\nfailed\tO\nto\tO\naffect\tO\nhyperactivity\tB-Disease\ninduced\tO\nby\tO\namphetamine\tB-Chemical\nor\tO\nnaturally\tO\nobserved\tO\nin\tO\ndopamine\tB-Chemical\ntransporter\tO\n(\tO\nDAT\tO\n(\tO\n-\tO\n/\tO\n-\tO\n)\tO\n)\tO\nknockout\tO\nmice\tO\n(\tO\n10\tO\n-\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\n)\tO\n.\tO\n\nImportantly\tO\n,\tO\nboth\tO\nclassical\tO\n(\tO\nhaloperidol\tB-Chemical\n)\tO\nand\tO\natypical\tO\n(\tO\nolanzapine\tB-Chemical\n,\tO\nclozapine\tB-Chemical\nand\tO\naripiprazole\tB-Chemical\n)\tO\nantipsychotics\tO\nwere\tO\neffective\tO\nin\tO\nall\tO\nthese\tO\nmodels\tO\nof\tO\nhyperactivity\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nunlike\tO\nthese\tO\nlatter\tO\n,\tO\nSSR103800\tB-Chemical\ndid\tO\nnot\tO\nproduce\tO\ncatalepsy\tB-Disease\n(\tO\nretention\tO\non\tO\nthe\tO\nbar\tO\ntest\tO\n)\tO\nup\tO\nto\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\np\tO\n.\tO\no\tO\n.\tO\n\nTogether\tO\nthese\tO\nfindings\tO\nshow\tO\nthat\tO\nthe\tO\nGlyT1\tO\ninhibitor\tO\n,\tO\nSSR103800\tB-Chemical\n,\tO\nproduces\tO\nantipsychotic\tO\n-\tO\nlike\tO\neffects\tO\n,\tO\nwhich\tO\ndiffer\tO\nfrom\tO\nthose\tO\nobserved\tO\nwith\tO\ncompounds\tO\nprimarily\tO\ntargeting\tO\nthe\tO\ndopaminergic\tO\nsystem\tO\n,\tO\nand\tO\nhas\tO\na\tO\nreduced\tO\nside\tO\n-\tO\neffect\tO\npotential\tO\nas\tO\ncompared\tO\nwith\tO\nthese\tO\nlatter\tO\ndrugs\tO\n.\tO\n\nPyrrolidine\tB-Chemical\ndithiocarbamate\tI-Chemical\nprotects\tO\nthe\tO\npiriform\tO\ncortex\tO\nin\tO\nthe\tO\npilocarpine\tB-Chemical\nstatus\tB-Disease\nepilepticus\tI-Disease\nmodel\tO\n.\tO\n\nPyrrolidine\tB-Chemical\ndithiocarbamate\tI-Chemical\n(\tO\nPDTC\tB-Chemical\n)\tO\nhas\tO\na\tO\ndual\tO\nmechanism\tO\nof\tO\naction\tO\nas\tO\nan\tO\nantioxidant\tO\nand\tO\nan\tO\ninhibitor\tO\nof\tO\nthe\tO\ntranscription\tO\nfactor\tO\nkappa\tO\n-\tO\nbeta\tO\n.\tO\n\nBoth\tO\n,\tO\nproduction\tO\nof\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\nas\tO\nwell\tO\nas\tO\nactivation\tO\nof\tO\nNF\tO\n-\tO\nkappaB\tO\nhave\tO\nbeen\tO\nimplicated\tO\nin\tO\nsevere\tO\nneuronal\tB-Disease\ndamage\tI-Disease\nin\tO\ndifferent\tO\nsub\tO\n-\tO\nregions\tO\nof\tO\nthe\tO\nhippocampus\tO\nas\tO\nwell\tO\nas\tO\nin\tO\nthe\tO\nsurrounding\tO\ncortices\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nPDTC\tB-Chemical\non\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n-\tO\nassociated\tO\ncell\tO\nloss\tO\nin\tO\nthe\tO\nhippocampus\tO\nand\tO\npiriform\tO\ncortex\tO\nwas\tO\nevaluated\tO\nin\tO\nthe\tO\nrat\tO\nfractionated\tO\npilocarpine\tB-Chemical\nmodel\tO\n.\tO\n\nTreatment\tO\nwith\tO\n150\tO\nmg\tO\n/\tO\nkg\tO\nPDTC\tB-Chemical\nbefore\tO\nand\tO\nfollowing\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nsignificantly\tO\nincreased\tO\nthe\tO\nmortality\tO\nrate\tO\nto\tO\n100\tO\n%\tO\n.\tO\n\nAdministration\tO\nof\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nPDTC\tB-Chemical\n(\tO\nlow\tO\n-\tO\ndose\tO\n)\tO\ndid\tO\nnot\tO\nexert\tO\nmajor\tO\neffects\tO\non\tO\nthe\tO\ndevelopment\tO\nof\tO\na\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\nor\tO\nthe\tO\nmortality\tO\nrate\tO\n.\tO\n\nIn\tO\nvehicle\tO\n-\tO\ntreated\tO\nrats\tO\n,\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\ncaused\tO\npronounced\tO\nneuronal\tB-Disease\ndamage\tI-Disease\nin\tO\nthe\tO\npiriform\tO\ncortex\tO\ncomprising\tO\nboth\tO\npyramidal\tO\ncells\tO\nand\tO\ninterneurons\tO\n.\tO\n\nLow\tO\n-\tO\ndose\tO\nPDTC\tB-Chemical\ntreatment\tO\nalmost\tO\ncompletely\tO\nprotected\tO\nfrom\tO\nlesions\tO\nin\tO\nthe\tO\npiriform\tO\ncortex\tO\n.\tO\n\nA\tO\nsignificant\tO\ndecrease\tO\nin\tO\nneuronal\tO\ndensity\tO\nof\tO\nthe\tO\nhippocampal\tO\nhilar\tO\nformation\tO\nwas\tO\nidentified\tO\nin\tO\nvehicle\tO\n-\tO\nand\tO\nPDTC\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nfollowing\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\nNF\tO\n-\tO\nkappaB\tO\ninhibitor\tO\nand\tO\nantioxidant\tO\nPDTC\tB-Chemical\nprotected\tO\nthe\tO\npiriform\tO\ncortex\tO\n,\tO\nwhereas\tO\nit\tO\ndid\tO\nnot\tO\naffect\tO\nhilar\tO\nneuronal\tB-Disease\nloss\tI-Disease\n.\tO\n\nThese\tO\ndata\tO\nmight\tO\nindicate\tO\nthat\tO\nthe\tO\ngeneration\tO\nof\tO\nreactive\tO\noxygen\tB-Chemical\nspecies\tO\nand\tO\nactivation\tO\nof\tO\nNF\tO\n-\tO\nkappaB\tO\nplays\tO\na\tO\nmore\tO\ncentral\tO\nrole\tO\nin\tO\nseizure\tB-Disease\n-\tO\nassociated\tO\nneuronal\tB-Disease\ndamage\tI-Disease\nin\tO\nthe\tO\ntemporal\tO\ncortex\tO\nas\tO\ncompared\tO\nto\tO\nthe\tO\nhippocampal\tO\nhilus\tO\n.\tO\n\nHowever\tO\n,\tO\nfuture\tO\ninvestigations\tO\nare\tO\nnecessary\tO\nto\tO\nexactly\tO\nanalyze\tO\nthe\tO\nbiochemical\tO\nmechanisms\tO\nby\tO\nwhich\tO\nPDTC\tB-Chemical\nexerted\tO\nits\tO\nbeneficial\tO\neffects\tO\nin\tO\nthe\tO\npiriform\tO\ncortex\tO\n.\tO\n\nAnaesthetists\tO\n'\tO\nnightmare\tO\n:\tO\nmasseter\tB-Disease\nspasm\tI-Disease\nafter\tO\ninduction\tO\nin\tO\nan\tO\nundiagnosed\tO\ncase\tO\nof\tO\nmyotonia\tB-Disease\ncongenita\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\nan\tO\nundiagnosed\tO\ncase\tO\nof\tO\nmyotonia\tB-Disease\ncongenita\tI-Disease\nin\tO\na\tO\n24\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npreviously\tO\nhealthy\tO\nprimigravida\tO\n,\tO\nwho\tO\ndeveloped\tO\nlife\tO\nthreatening\tO\nmasseter\tB-Disease\nspasm\tI-Disease\nfollowing\tO\na\tO\nstandard\tO\ndose\tO\nof\tO\nintravenous\tO\nsuxamethonium\tB-Chemical\nfor\tO\ninduction\tO\nof\tO\nanaesthesia\tO\n.\tO\n\nNeither\tO\nthe\tO\npatient\tO\nnor\tO\nthe\tO\nanaesthetist\tO\nwas\tO\naware\tO\nof\tO\nthe\tO\ndiagnosis\tO\nbefore\tO\nthis\tO\npotentially\tO\nlethal\tO\ncomplication\tO\noccurred\tO\n.\tO\n\nTwin\tO\npreterm\tO\nneonates\tO\nwith\tO\ncardiac\tB-Disease\ntoxicity\tI-Disease\nrelated\tO\nto\tO\nlopinavir\tB-Chemical\n/\tI-Chemical\nritonavir\tI-Chemical\ntherapy\tO\n.\tO\n\nWe\tO\nreport\tO\ntwin\tO\nneonates\tO\nwho\tO\nwere\tO\nborn\tO\nprematurely\tO\nat\tO\n32\tO\nweeks\tO\nof\tO\ngestation\tO\nto\tO\na\tO\nmother\tO\nwith\tO\nhuman\tB-Disease\nimmunodeficiency\tI-Disease\nvirus\tI-Disease\ninfection\tI-Disease\n.\tO\n\nOne\tO\nof\tO\nthe\tO\ntwins\tO\ndeveloped\tO\ncomplete\tO\nheart\tB-Disease\nblock\tI-Disease\nand\tO\ndilated\tB-Disease\ncardiomyopathy\tI-Disease\nrelated\tO\nto\tO\nlopinavir\tB-Chemical\n/\tI-Chemical\nritonavir\tI-Chemical\ntherapy\tO\n,\tO\na\tO\nboosted\tO\nprotease\tO\n-\tO\ninhibitor\tO\nagent\tO\n,\tO\nwhile\tO\nthe\tO\nother\tO\ntwin\tO\ndeveloped\tO\nmild\tO\nbradycardia\tB-Disease\n.\tO\n\nWe\tO\nrecommend\tO\ncaution\tO\nin\tO\nthe\tO\nuse\tO\nof\tO\nlopinavir\tB-Chemical\n/\tI-Chemical\nritonavir\tI-Chemical\nin\tO\nthe\tO\nimmediate\tO\nneonatal\tO\nperiod\tO\n.\tO\n\nWhen\tO\ndrugs\tO\ndisappear\tO\nfrom\tO\nthe\tO\npatient\tO\n:\tO\nelimination\tO\nof\tO\nintravenous\tO\nmedication\tO\nby\tO\nhemodiafiltration\tO\n.\tO\n\nTwenty\tO\n-\tO\nthree\tO\nhours\tO\nafter\tO\nheart\tO\ntransplantation\tO\n,\tO\nlife\tO\n-\tO\nthreatening\tO\nacute\tO\nright\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\nwas\tO\ndiagnosed\tO\nin\tO\na\tO\npatient\tO\nrequiring\tO\ncontinuous\tO\nvenovenous\tO\nhemodiafiltration\tO\n(\tO\nCVVHDF\tO\n)\tO\n.\tO\n\nIncreasing\tO\ndoses\tO\nof\tO\ncatecholamines\tB-Chemical\n,\tO\nsedatives\tO\n,\tO\nand\tO\nmuscle\tO\nrelaxants\tO\nadministered\tO\nthrough\tO\na\tO\ncentral\tO\nvenous\tO\ncatheter\tO\nwere\tO\nineffective\tO\n.\tO\n\nHowever\tO\n,\tO\na\tO\nbolus\tO\nof\tO\nepinephrine\tB-Chemical\ninjected\tO\nthrough\tO\nan\tO\nalternative\tO\ncatheter\tO\nprovoked\tO\na\tO\nhypertensive\tB-Disease\ncrisis\tO\n.\tO\n\nThus\tO\n,\tO\ninterference\tO\nwith\tO\nthe\tO\ncentral\tO\nvenous\tO\ninfusion\tO\nby\tO\nthe\tO\ndialysis\tO\ncatheter\tO\nwas\tO\nsuspected\tO\n.\tO\n\nThe\tO\ncatheters\tO\nwere\tO\nchanged\tO\n,\tO\nand\tO\nhemodynamics\tO\nstabilized\tO\nat\tO\nlower\tO\ncatecholamine\tB-Chemical\ndoses\tO\n.\tO\n\nWhen\tO\nthe\tO\neffects\tO\nof\tO\nIV\tO\ndrugs\tO\nare\tO\ninadequate\tO\nin\tO\npatients\tO\nreceiving\tO\nCVVHDF\tO\n,\tO\ninterference\tO\nwith\tO\nadjacent\tO\ncatheters\tO\nresulting\tO\nin\tO\nelimination\tO\nof\tO\nthe\tO\ndrug\tO\nby\tO\nCVVHDF\tO\nshould\tO\nbe\tO\nsuspected\tO\n.\tO\n\nLess\tO\nfrequent\tO\nlithium\tB-Chemical\nadministration\tO\nand\tO\nlower\tO\nurine\tO\nvolume\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\ndetermine\tO\nwhether\tO\npatients\tO\nmaintained\tO\non\tO\na\tO\nregimen\tO\nof\tO\nlithium\tB-Chemical\non\tO\na\tO\nonce\tO\n-\tO\nper\tO\n-\tO\nday\tO\nschedule\tO\nhave\tO\nlower\tO\nurine\tO\nvolumes\tO\nthan\tO\ndo\tO\npatients\tO\nreceiving\tO\nmultiple\tO\ndoses\tO\nper\tO\nday\tO\n.\tO\n\nMETHOD\tO\n:\tO\nThis\tO\nwas\tO\na\tO\ncross\tO\n-\tO\nsectional\tO\nstudy\tO\nof\tO\n85\tO\npatients\tO\nfrom\tO\na\tO\nlithium\tB-Chemical\nclinic\tO\nwho\tO\nreceived\tO\ndifferent\tO\ndose\tO\nschedules\tO\n.\tO\n\nPatients\tO\nwere\tO\nadmitted\tO\nto\tO\nthe\tO\nhospital\tO\nfor\tO\nmeasurement\tO\nof\tO\nlithium\tB-Chemical\nlevel\tO\n,\tO\ncreatinine\tB-Chemical\nclearance\tO\n,\tO\nurine\tO\nvolume\tO\n,\tO\nand\tO\nmaximum\tO\nosmolality\tO\n.\tO\n\nRESULTS\tO\n:\tO\nMultiple\tO\ndaily\tO\ndoses\tO\nof\tO\nlithium\tB-Chemical\nwere\tO\nassociated\tO\nwith\tO\nhigher\tO\nurine\tO\nvolumes\tO\n.\tO\n\nThe\tO\ndosing\tO\nschedule\tO\n,\tO\nduration\tO\nof\tO\nlithium\tB-Chemical\ntreatment\tO\n,\tO\nand\tO\ndaily\tO\ndose\tO\nof\tO\nlithium\tB-Chemical\ndid\tO\nnot\tO\naffect\tO\nmaximum\tO\nosmolality\tO\nor\tO\ncreatinine\tB-Chemical\nclearance\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nUrine\tO\nvolume\tO\ncan\tO\nbe\tO\nreduced\tO\nby\tO\ngiving\tO\nlithium\tB-Chemical\nonce\tO\ndaily\tO\nand\tO\n/\tO\nor\tO\nby\tO\nlowering\tO\nthe\tO\ntotal\tO\ndaily\tO\ndose\tO\n.\tO\n\nLithium\tB-Chemical\n-\tO\ninduced\tO\npolyuria\tB-Disease\nseems\tO\nto\tO\nbe\tO\nrelated\tO\nto\tO\nextrarenal\tO\nas\tO\nwell\tO\nas\tO\nto\tO\nrenal\tO\neffects\tO\n.\tO\n\nAntibacterial\tO\nmedication\tO\nuse\tO\nduring\tO\npregnancy\tO\nand\tO\nrisk\tO\nof\tO\nbirth\tB-Disease\ndefects\tI-Disease\n:\tO\nNational\tO\nBirth\tB-Disease\nDefects\tI-Disease\nPrevention\tO\nStudy\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nestimate\tO\nthe\tO\nassociation\tO\nbetween\tO\nantibacterial\tO\nmedications\tO\nand\tO\nselected\tO\nbirth\tB-Disease\ndefects\tI-Disease\n.\tO\n\nDESIGN\tO\n,\tO\nSETTING\tO\n,\tO\nAND\tO\nPARTICIPANTS\tO\n:\tO\nPopulation\tO\n-\tO\nbased\tO\n,\tO\nmultisite\tO\n,\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nof\tO\nwomen\tO\nwho\tO\nhad\tO\npregnancies\tO\naffected\tO\nby\tO\n1\tO\nof\tO\nmore\tO\nthan\tO\n30\tO\neligible\tO\nmajor\tO\nbirth\tB-Disease\ndefects\tI-Disease\nidentified\tO\nvia\tO\nbirth\tB-Disease\ndefect\tI-Disease\nsurveillance\tO\nprograms\tO\nin\tO\n10\tO\nstates\tO\n(\tO\nn\tO\n=\tO\n13\tO\n155\tO\n)\tO\nand\tO\ncontrol\tO\nwomen\tO\nrandomly\tO\nselected\tO\nfrom\tO\nthe\tO\nsame\tO\ngeographical\tO\nregions\tO\n(\tO\nn\tO\n=\tO\n4941\tO\n)\tO\n.\tO\n\nMAIN\tO\nEXPOSURE\tO\n:\tO\nReported\tO\nmaternal\tO\nuse\tO\nof\tO\nantibacterials\tO\n(\tO\n1\tO\nmonth\tO\nbefore\tO\npregnancy\tO\nthrough\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nfirst\tO\ntrimester\tO\n)\tO\n.\tO\n\nMAIN\tO\nOUTCOME\tO\nMEASURE\tO\n:\tO\nOdds\tO\nratios\tO\n(\tO\nORs\tO\n)\tO\nmeasuring\tO\nthe\tO\nassociation\tO\nbetween\tO\nantibacterial\tO\nuse\tO\nand\tO\nselected\tO\nbirth\tB-Disease\ndefects\tI-Disease\nadjusted\tO\nfor\tO\npotential\tO\nconfounders\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nreported\tO\nuse\tO\nof\tO\nantibacterials\tO\nincreased\tO\nduring\tO\npregnancy\tO\n,\tO\npeaking\tO\nduring\tO\nthe\tO\nthird\tO\nmonth\tO\n.\tO\n\nSulfonamides\tB-Chemical\nwere\tO\nassociated\tO\nwith\tO\nanencephaly\tB-Disease\n(\tO\nadjusted\tO\nOR\tO\n[\tO\nAOR\tO\n]\tO\n=\tO\n3\tO\n.\tO\n4\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n,\tO\n1\tO\n.\tO\n3\tO\n-\tO\n8\tO\n.\tO\n8\tO\n)\tO\n,\tO\nhypoplastic\tB-Disease\nleft\tI-Disease\nheart\tI-Disease\nsyndrome\tI-Disease\n(\tO\nAOR\tO\n=\tO\n3\tO\n.\tO\n2\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n3\tO\n-\tO\n7\tO\n.\tO\n6\tO\n)\tO\n,\tO\ncoarctation\tB-Disease\nof\tI-Disease\nthe\tI-Disease\naorta\tI-Disease\n(\tO\nAOR\tO\n=\tO\n2\tO\n.\tO\n7\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n3\tO\n-\tO\n5\tO\n.\tO\n6\tO\n)\tO\n,\tO\nchoanal\tB-Disease\natresia\tI-Disease\n(\tO\nAOR\tO\n=\tO\n8\tO\n.\tO\n0\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n2\tO\n.\tO\n7\tO\n-\tO\n23\tO\n.\tO\n5\tO\n)\tO\n,\tO\ntransverse\tB-Disease\nlimb\tI-Disease\ndeficiency\tI-Disease\n(\tO\nAOR\tO\n=\tO\n2\tO\n.\tO\n5\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n0\tO\n-\tO\n5\tO\n.\tO\n9\tO\n)\tO\n,\tO\nand\tO\ndiaphragmatic\tB-Disease\nhernia\tI-Disease\n(\tO\nAOR\tO\n=\tO\n2\tO\n.\tO\n4\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n1\tO\n-\tO\n5\tO\n.\tO\n4\tO\n)\tO\n.\tO\n\nNitrofurantoins\tB-Chemical\nwere\tO\nassociated\tO\nwith\tO\nanophthalmia\tB-Disease\nor\tO\nmicrophthalmos\tB-Disease\n(\tO\nAOR\tO\n=\tO\n3\tO\n.\tO\n7\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n1\tO\n-\tO\n12\tO\n.\tO\n2\tO\n)\tO\n,\tO\nhypoplastic\tB-Disease\nleft\tI-Disease\nheart\tI-Disease\nsyndrome\tI-Disease\n(\tO\nAOR\tO\n=\tO\n4\tO\n.\tO\n2\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n9\tO\n-\tO\n9\tO\n.\tO\n1\tO\n)\tO\n,\tO\natrial\tB-Disease\nseptal\tI-Disease\ndefects\tI-Disease\n(\tO\nAOR\tO\n=\tO\n1\tO\n.\tO\n9\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n1\tO\n-\tO\n3\tO\n.\tO\n4\tO\n)\tO\n,\tO\nand\tO\ncleft\tB-Disease\nlip\tI-Disease\nwith\tO\ncleft\tB-Disease\npalate\tI-Disease\n(\tO\nAOR\tO\n=\tO\n2\tO\n.\tO\n1\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n1\tO\n.\tO\n2\tO\n-\tO\n3\tO\n.\tO\n9\tO\n)\tO\n.\tO\n\nOther\tO\nantibacterial\tO\nagents\tO\nthat\tO\nshowed\tO\nassociations\tO\nincluded\tO\nerythromycins\tB-Chemical\n(\tO\n2\tO\ndefects\tO\n)\tO\n,\tO\npenicillins\tB-Chemical\n(\tO\n1\tO\ndefect\tO\n)\tO\n,\tO\ncephalosporins\tB-Chemical\n(\tO\n1\tO\ndefect\tO\n)\tO\n,\tO\nand\tO\nquinolones\tB-Chemical\n(\tO\n1\tO\ndefect\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nReassuringly\tO\n,\tO\npenicillins\tB-Chemical\n,\tO\nerythromycins\tB-Chemical\n,\tO\nand\tO\ncephalosporins\tB-Chemical\n,\tO\nalthough\tO\nused\tO\ncommonly\tO\nby\tO\npregnant\tO\nwomen\tO\n,\tO\nwere\tO\nnot\tO\nassociated\tO\nwith\tO\nmany\tO\nbirth\tB-Disease\ndefects\tI-Disease\n.\tO\n\nSulfonamides\tB-Chemical\nand\tO\nnitrofurantoins\tB-Chemical\nwere\tO\nassociated\tO\nwith\tO\nseveral\tO\nbirth\tB-Disease\ndefects\tI-Disease\n,\tO\nindicating\tO\na\tO\nneed\tO\nfor\tO\nadditional\tO\nscrutiny\tO\n.\tO\n\nDifferential\tO\nimpact\tO\nof\tO\nimmune\tO\nescape\tO\nmutations\tO\nG145R\tO\nand\tO\nP120T\tO\non\tO\nthe\tO\nreplication\tO\nof\tO\nlamivudine\tB-Chemical\n-\tO\nresistant\tO\nhepatitis\tB-Chemical\nB\tI-Chemical\nvirus\tI-Chemical\ne\tI-Chemical\nantigen\tI-Chemical\n-\tO\npositive\tO\nand\tO\n-\tO\nnegative\tO\nstrains\tO\n.\tO\n\nImmune\tO\nescape\tO\nvariants\tO\nof\tO\nthe\tO\nhepatitis\tB-Disease\nB\tI-Disease\nvirus\tO\n(\tO\nHBV\tO\n)\tO\nrepresent\tO\nan\tO\nemerging\tO\nclinical\tO\nchallenge\tO\n,\tO\nbecause\tO\nthey\tO\ncan\tO\nbe\tO\nassociated\tO\nwith\tO\nvaccine\tO\nescape\tO\n,\tO\nHBV\tO\nreactivation\tO\n,\tO\nand\tO\nfailure\tO\nof\tO\ndiagnostic\tO\ntests\tO\n.\tO\n\nRecent\tO\ndata\tO\nsuggest\tO\na\tO\npreferential\tO\nselection\tO\nof\tO\nimmune\tO\nescape\tO\nmutants\tO\nin\tO\ndistinct\tO\nperipheral\tO\nblood\tO\nleukocyte\tO\ncompartments\tO\nof\tO\ninfected\tO\nindividuals\tO\n.\tO\n\nWe\tO\ntherefore\tO\nsystematically\tO\nanalyzed\tO\nthe\tO\nfunctional\tO\nimpact\tO\nof\tO\nthe\tO\nmost\tO\nprevalent\tO\nimmune\tO\nescape\tO\nvariants\tO\n,\tO\nthe\tO\nsG145R\tO\nand\tO\nsP120T\tO\nmutants\tO\n,\tO\non\tO\nthe\tO\nviral\tO\nreplication\tO\nefficacy\tO\nand\tO\nantiviral\tO\ndrug\tO\nsusceptibility\tO\nof\tO\ncommon\tO\ntreatment\tO\n-\tO\nassociated\tO\nmutants\tO\nwith\tO\nresistance\tO\nto\tO\nlamivudine\tB-Chemical\n(\tO\nLAM\tB-Chemical\n)\tO\nand\tO\n/\tO\nor\tO\nHBeAg\tB-Chemical\nnegativity\tO\n.\tO\n\nReplication\tO\n-\tO\ncompetent\tO\nHBV\tO\nstrains\tO\nwith\tO\nsG145R\tO\nor\tO\nsP120T\tO\nand\tO\nLAM\tB-Chemical\nresistance\tO\n(\tO\nrtM204I\tO\nor\tO\nrtL180M\tO\n/\tO\nrtM204V\tO\n)\tO\nwere\tO\ngenerated\tO\non\tO\nan\tO\nHBeAg\tB-Chemical\n-\tO\npositive\tO\nand\tO\nan\tO\nHBeAg\tB-Chemical\n-\tO\nnegative\tO\nbackground\tO\nwith\tO\nprecore\tO\n(\tO\nPC\tO\n)\tO\nand\tO\nbasal\tO\ncore\tO\npromoter\tO\n(\tO\nBCP\tO\n)\tO\nmutants\tO\n.\tO\n\nThe\tO\nsG145R\tO\nmutation\tO\nstrongly\tO\nreduced\tO\nHBsAg\tB-Chemical\nlevels\tO\nand\tO\nwas\tO\nable\tO\nto\tO\nfully\tO\nrestore\tO\nthe\tO\nimpaired\tO\nreplication\tO\nof\tO\nLAM\tB-Chemical\n-\tO\nresistant\tO\nHBV\tO\nmutants\tO\nto\tO\nthe\tO\nlevels\tO\nof\tO\nwild\tO\n-\tO\ntype\tO\nHBV\tO\n,\tO\nand\tO\nPC\tO\nor\tO\nBCP\tO\nmutations\tO\nfurther\tO\nenhanced\tO\nviral\tO\nreplication\tO\n.\tO\n\nAlthough\tO\nthe\tO\nsP120T\tO\nsubstitution\tO\nalso\tO\nimpaired\tO\nHBsAg\tB-Chemical\nsecretion\tO\n,\tO\nit\tO\ndid\tO\nnot\tO\nenhance\tO\nthe\tO\nreplication\tO\nof\tO\nLAM\tB-Chemical\n-\tO\nresistant\tO\nclones\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nconcomitant\tO\noccurrence\tO\nof\tO\nHBeAg\tB-Chemical\nnegativity\tO\n(\tO\nPC\tO\n/\tO\nBCP\tO\n)\tO\n,\tO\nsP120T\tO\n,\tO\nand\tO\nLAM\tB-Chemical\nresistance\tO\nresulted\tO\nin\tO\nthe\tO\nrestoration\tO\nof\tO\nreplication\tO\nto\tO\nlevels\tO\nof\tO\nwild\tO\n-\tO\ntype\tO\nHBV\tO\n.\tO\n\nIn\tO\nall\tO\nclones\tO\nwith\tO\ncombined\tO\nimmune\tO\nescape\tO\nand\tO\nLAM\tB-Chemical\nresistance\tO\nmutations\tO\n,\tO\nthe\tO\nnucleotide\tB-Chemical\nanalogues\tO\nadefovir\tB-Chemical\nand\tO\ntenofovir\tB-Chemical\nremained\tO\neffective\tO\nin\tO\nsuppressing\tO\nviral\tO\nreplication\tO\nin\tO\nvitro\tO\n.\tO\n\nThese\tO\nfindings\tO\nreveal\tO\nthe\tO\ndifferential\tO\nimpact\tO\nof\tO\nimmune\tO\nescape\tO\nvariants\tO\non\tO\nthe\tO\nreplication\tO\nand\tO\ndrug\tO\nsusceptibility\tO\nof\tO\ncomplex\tO\nHBV\tO\nmutants\tO\n,\tO\nsupporting\tO\nthe\tO\nneed\tO\nof\tO\nclose\tO\nsurveillance\tO\nand\tO\ntreatment\tO\nadjustment\tO\nin\tO\nresponse\tO\nto\tO\nthe\tO\nselection\tO\nof\tO\ndistinct\tO\nmutational\tO\npatterns\tO\n.\tO\n\nHemolytic\tB-Disease\nanemia\tI-Disease\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nomeprazole\tB-Chemical\n.\tO\n\nOmeprazole\tB-Chemical\nis\tO\nthe\tO\nfirst\tO\ndrug\tO\ndesigned\tO\nto\tO\nblock\tO\nthe\tO\nfinal\tO\nstep\tO\nin\tO\nthe\tO\nacid\tO\nsecretory\tO\nprocess\tO\nwithin\tO\nthe\tO\nparietal\tO\ncell\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nbe\tO\nextremely\tO\neffective\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\npeptic\tB-Disease\nulcer\tI-Disease\ndisease\tI-Disease\n,\tO\nreflux\tB-Disease\nesophagitis\tI-Disease\n,\tO\nand\tO\nthe\tO\nZollinger\tB-Disease\n-\tI-Disease\nEllison\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nAlthough\tO\nclinical\tO\nexperience\tO\nwith\tO\nomeprazole\tB-Chemical\nis\tO\nstill\tO\nlimited\tO\n,\tO\nmany\tO\ncontrolled\tO\nstudies\tO\nhave\tO\nestablished\tO\nthe\tO\nshort\tO\n-\tO\nterm\tO\nsafety\tO\nof\tO\nthis\tO\ndrug\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\nfirst\tO\ncase\tO\nof\tO\na\tO\nserious\tO\nshort\tO\n-\tO\nterm\tO\nadverse\tO\nreaction\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nomeprazole\tB-Chemical\n:\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nThe\tO\npatient\tO\ndeveloped\tO\nweakness\tO\n,\tO\nlethargy\tB-Disease\n,\tO\nand\tO\nshortness\tB-Disease\nof\tI-Disease\nbreath\tI-Disease\n2\tO\ndays\tO\nafter\tO\nstarting\tO\ntherapy\tO\nwith\tO\nomeprazole\tB-Chemical\n.\tO\n\nTwo\tO\nweeks\tO\nafter\tO\nthe\tO\ninitiation\tO\nof\tO\ntherapy\tO\n,\tO\nher\tO\nhematocrit\tO\nhad\tO\ndecreased\tO\nfrom\tO\n44\tO\n.\tO\n1\tO\n%\tO\nto\tO\n20\tO\n.\tO\n4\tO\n%\tO\n,\tO\nand\tO\nshe\tO\nhad\tO\na\tO\npositive\tO\ndirect\tO\nCoombs\tO\nantiglobulin\tO\ntest\tO\nand\tO\nan\tO\nelevated\tO\nindirect\tO\nbilirubin\tB-Chemical\n.\tO\n\nAfter\tO\nshe\tO\ndiscontinued\tO\nthe\tO\nomeprazole\tB-Chemical\n,\tO\nher\tO\nhemoglobin\tO\nand\tO\nhematocrit\tO\ngradually\tO\nreturned\tO\nto\tO\nnormal\tO\n.\tO\n\nThe\tO\nmechanism\tO\nby\tO\nwhich\tO\nomeprazole\tB-Chemical\ncaused\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nis\tO\nuncertain\tO\n,\tO\nbut\tO\nphysicians\tO\nshould\tO\nbe\tO\nalerted\tO\nto\tO\nthis\tO\npossible\tO\nadverse\tO\neffect\tO\n.\tO\n\nPhenylephrine\tB-Chemical\nbut\tO\nnot\tO\nephedrine\tB-Chemical\nreduces\tB-Disease\nfrontal\tI-Disease\nlobe\tI-Disease\noxygenation\tI-Disease\nfollowing\tO\nanesthesia\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nVasopressor\tO\nagents\tO\nare\tO\nused\tO\nto\tO\ncorrect\tO\nanesthesia\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nWe\tO\ndescribe\tO\nthe\tO\neffect\tO\nof\tO\nphenylephrine\tB-Chemical\nand\tO\nephedrine\tB-Chemical\non\tO\nfrontal\tO\nlobe\tO\noxygenation\tO\n(\tO\nS\tO\n(\tO\nc\tO\n)\tO\nO\tO\n(\tO\n2\tO\n)\tO\n)\tO\nfollowing\tO\nanesthesia\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nFollowing\tO\ninduction\tO\nof\tO\nanesthesia\tO\nby\tO\nfentanyl\tB-Chemical\n(\tO\n0\tO\n.\tO\n15\tO\nmg\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n)\tO\nand\tO\npropofol\tB-Chemical\n(\tO\n2\tO\n.\tO\n0\tO\nmg\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n)\tO\n,\tO\n13\tO\npatients\tO\nreceived\tO\nphenylephrine\tB-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmg\tO\niv\tO\n)\tO\nand\tO\n12\tO\npatients\tO\nreceived\tO\nephedrine\tB-Chemical\n(\tO\n10\tO\nmg\tO\niv\tO\n)\tO\nto\tO\nrestore\tO\nmean\tO\narterial\tO\npressure\tO\n(\tO\nMAP\tO\n)\tO\n.\tO\n\nHeart\tO\nrate\tO\n(\tO\nHR\tO\n)\tO\n,\tO\nMAP\tO\n,\tO\nstroke\tB-Disease\nvolume\tO\n(\tO\nSV\tO\n)\tO\n,\tO\ncardiac\tO\noutput\tO\n(\tO\nCO\tO\n)\tO\n,\tO\nand\tO\nfrontal\tO\nlobe\tO\noxygenation\tO\n(\tO\nS\tO\n(\tO\nc\tO\n)\tO\nO\tO\n(\tO\n2\tO\n)\tO\n)\tO\nwere\tO\nregistered\tO\n.\tO\n\nRESULTS\tO\n:\tO\nInduction\tO\nof\tO\nanesthesia\tO\nwas\tO\nfollowed\tO\nby\tO\na\tB-Disease\ndecrease\tI-Disease\nin\tI-Disease\nMAP\tI-Disease\n,\tI-Disease\nHR\tI-Disease\n,\tI-Disease\nSV\tI-Disease\n,\tI-Disease\nand\tI-Disease\nCO\tI-Disease\nconcomitant\tO\nwith\tO\nan\tO\nelevation\tO\nin\tO\nS\tO\n(\tO\nc\tO\n)\tO\nO\tO\n(\tO\n2\tO\n)\tO\n.\tO\n\nAfter\tO\nadministration\tO\nof\tO\nphenylephrine\tB-Chemical\n,\tO\nMAP\tO\nincreased\tO\n(\tO\n51\tO\n+\tO\n/\tO\n-\tO\n12\tO\nto\tO\n81\tO\n+\tO\n/\tO\n-\tO\n13\tO\nmmHg\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n;\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\na\tO\n14\tO\n%\tO\n(\tO\nfrom\tO\n70\tO\n+\tO\n/\tO\n-\tO\n8\tO\n%\tO\nto\tO\n60\tO\n+\tO\n/\tO\n-\tO\n7\tO\n%\tO\n)\tO\nreduction\tO\nin\tO\nS\tO\n(\tO\nc\tO\n)\tO\nO\tO\n(\tO\n2\tO\n)\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nfollowed\tO\nwith\tO\nno\tO\nchange\tO\nin\tO\nCO\tO\n(\tO\n3\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n1\tO\nto\tO\n3\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n9\tO\nl\tO\nmin\tO\n(\tO\n-\tO\n1\tO\n)\tO\n)\tO\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nephedrine\tB-Chemical\nled\tO\nto\tO\na\tO\nsimilar\tO\nincrease\tO\nin\tO\nMAP\tO\n(\tO\n53\tO\n+\tO\n/\tO\n-\tO\n9\tO\nto\tO\n79\tO\n+\tO\n/\tO\n-\tO\n8\tO\nmmHg\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrestored\tO\nCO\tO\n(\tO\n3\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n2\tO\nto\tO\n5\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n3\tO\nl\tO\nmin\tO\n(\tO\n-\tO\n1\tO\n)\tO\n)\tO\n,\tO\nand\tO\npreserved\tO\nS\tO\n(\tO\nc\tO\n)\tO\nO\tO\n(\tO\n2\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nutilization\tO\nof\tO\nphenylephrine\tB-Chemical\nto\tO\ncorrect\tO\nhypotension\tB-Disease\ninduced\tO\nby\tO\nanesthesia\tO\nhas\tO\na\tO\nnegative\tO\nimpact\tO\non\tO\nS\tO\n(\tO\nc\tO\n)\tO\nO\tO\n(\tO\n2\tO\n)\tO\nwhile\tO\nephedrine\tB-Chemical\nmaintains\tO\nfrontal\tO\nlobe\tO\noxygenation\tO\npotentially\tO\nrelated\tO\nto\tO\nan\tO\nincrease\tO\nin\tO\nCO\tO\n.\tO\n\nProlonged\tO\nelevation\tO\nof\tO\nplasma\tO\nargatroban\tB-Chemical\nin\tO\na\tO\ncardiac\tO\ntransplant\tO\npatient\tO\nwith\tO\na\tO\nsuspected\tO\nhistory\tO\nof\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\nwith\tO\nthrombosis\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nDirect\tO\nthrombin\tO\ninhibitors\tO\n(\tO\nDTIs\tO\n)\tO\nprovide\tO\nan\tO\nalternative\tO\nmethod\tO\nof\tO\nanticoagulation\tO\nfor\tO\npatients\tO\nwith\tO\na\tO\nhistory\tO\nof\tO\nheparin\tB-Chemical\n-\tO\ninduced\tO\nthrombocytopenia\tB-Disease\n(\tO\nHIT\tB-Disease\n)\tO\nor\tO\nHIT\tB-Disease\nwith\tO\nthrombosis\tB-Disease\n(\tO\nHITT\tB-Disease\n)\tO\nundergoing\tO\ncardiopulmonary\tO\nbypass\tO\n(\tO\nCPB\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\nfollowing\tO\nreport\tO\n,\tO\na\tO\n65\tO\n-\tO\nyear\tO\n-\tO\nold\tO\ncritically\tB-Disease\nill\tI-Disease\npatient\tO\nwith\tO\na\tO\nsuspected\tO\nhistory\tO\nof\tO\nHITT\tB-Disease\nwas\tO\nadministered\tO\nargatroban\tB-Chemical\nfor\tO\nanticoagulation\tO\non\tO\nbypass\tO\nduring\tO\nheart\tO\ntransplantation\tO\n.\tO\n\nThe\tO\npatient\tO\nrequired\tO\nmassive\tO\ntransfusion\tO\nsupport\tO\n(\tO\n55\tO\nunits\tO\nof\tO\nred\tO\nblood\tO\ncells\tO\n,\tO\n42\tO\nunits\tO\nof\tO\nfresh\tO\n-\tO\nfrozen\tO\nplasma\tO\n,\tO\n40\tO\nunits\tO\nof\tO\ncryoprecipitate\tO\n,\tO\n40\tO\nunits\tO\nof\tO\nplatelets\tO\n,\tO\nand\tO\nthree\tO\ndoses\tO\nof\tO\nrecombinant\tO\nFactor\tO\nVIIa\tO\n)\tO\nfor\tO\nsevere\tO\nintraoperative\tB-Disease\nand\tI-Disease\npostoperative\tI-Disease\nbleeding\tI-Disease\n.\tO\n\nSTUDY\tO\nDESIGN\tO\nAND\tO\nMETHODS\tO\n:\tO\nPlasma\tO\nsamples\tO\nfrom\tO\nbefore\tO\nand\tO\nafter\tO\nCPB\tO\nwere\tO\nanalyzed\tO\npostoperatively\tO\nfor\tO\nargatroban\tB-Chemical\nconcentration\tO\nusing\tO\na\tO\nmodified\tO\necarin\tO\nclotting\tO\ntime\tO\n(\tO\nECT\tO\n)\tO\nassay\tO\n.\tO\n\nRESULTS\tO\n:\tO\nUnexpectedly\tO\nhigh\tO\nconcentrations\tO\nof\tO\nargatroban\tB-Chemical\nwere\tO\nmeasured\tO\nin\tO\nthese\tO\nsamples\tO\n(\tO\nrange\tO\n,\tO\n0\tO\n-\tO\n32\tO\nmicrog\tO\n/\tO\nmL\tO\n)\tO\n,\tO\nand\tO\na\tO\nprolonged\tO\nplasma\tO\nargatroban\tB-Chemical\nhalf\tO\nlife\tO\n(\tO\nt\tO\n(\tO\n1\tO\n/\tO\n2\tO\n)\tO\n)\tO\nof\tO\n514\tO\nminutes\tO\nwas\tO\nobserved\tO\n(\tO\npublished\tO\nelimination\tO\nt\tO\n(\tO\n1\tO\n/\tO\n2\tO\n)\tO\nis\tO\n39\tO\n-\tO\n51\tO\nminutes\tO\n[\tO\n<\tO\nor\tO\n=\tO\n181\tO\nminutes\tO\nwith\tO\nhepatic\tB-Disease\nimpairment\tI-Disease\n]\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCorrelation\tO\nof\tO\nplasma\tO\nargatroban\tB-Chemical\nconcentration\tO\nversus\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\ncoagulation\tO\nvariables\tO\nand\tO\nclinical\tO\ncourse\tO\nsuggest\tO\nthat\tO\nprolonged\tO\nelevated\tO\nlevels\tO\nof\tO\nplasma\tO\nargatroban\tB-Chemical\nmay\tO\nhave\tO\ncontributed\tO\nto\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nextended\tO\ncoagulopathy\tB-Disease\n.\tO\n\nBecause\tO\nDTIs\tO\ndo\tO\nnot\tO\nhave\tO\nreversal\tO\nagents\tO\n,\tO\nsurgical\tO\nteams\tO\nand\tO\ntransfusion\tO\nservices\tO\nshould\tO\nremain\tO\naware\tO\nof\tO\nthe\tO\npossibility\tO\nof\tO\nmassive\tO\ntransfusion\tO\nevents\tO\nduring\tO\nanticoagulation\tO\nwith\tO\nthese\tO\nagents\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nreport\tO\nto\tO\nmeasure\tO\nplasma\tO\nargatroban\tB-Chemical\nconcentration\tO\nin\tO\nthe\tO\ncontext\tO\nof\tO\nCPB\tO\nand\tO\nextended\tO\ncoagulopathy\tB-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nthe\tO\nadjunctive\tO\nbupropion\tB-Chemical\non\tO\nmale\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\ninduced\tO\nby\tO\na\tO\nselective\tB-Chemical\nserotonin\tI-Chemical\nreuptake\tI-Chemical\ninhibitor\tI-Chemical\n:\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\nplacebo\tO\n-\tO\ncontrolled\tO\nand\tO\nrandomized\tO\nstudy\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nadjunctive\tO\nbupropion\tB-Chemical\nsustained\tO\n-\tO\nrelease\tO\n(\tO\nSR\tO\n)\tO\non\tO\nmale\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\n(\tO\nSD\tB-Disease\n)\tO\ninduced\tO\nby\tO\na\tO\nselective\tB-Chemical\nserotonin\tI-Chemical\nreuptake\tI-Chemical\ninhibitor\tI-Chemical\n(\tO\nSSRI\tB-Chemical\n)\tO\n,\tO\nas\tO\nSD\tB-Disease\nis\tO\na\tO\ncommon\tO\nside\tO\n-\tO\neffect\tO\nof\tO\nSSRIs\tB-Chemical\nand\tO\nthe\tO\nmost\tO\neffective\tO\ntreatments\tO\nhave\tO\nyet\tO\nto\tO\nbe\tO\ndetermined\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nThe\tO\nrandomized\tO\nsample\tO\nconsisted\tO\nof\tO\n234\tO\neuthymic\tO\nmen\tO\nwho\tO\nwere\tO\nreceiving\tO\nsome\tO\ntype\tO\nof\tO\nSSRI\tB-Chemical\n.\tO\n\nThe\tO\nmen\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nbupropion\tB-Chemical\nSR\tO\n(\tO\n150\tO\nmg\tO\ntwice\tO\ndaily\tO\n,\tO\n117\tO\n)\tO\nor\tO\nplacebo\tO\n(\tO\ntwice\tO\ndaily\tO\n,\tO\n117\tO\n)\tO\nfor\tO\n12\tO\nweeks\tO\n.\tO\n\nEfficacy\tO\nwas\tO\nevaluated\tO\nusing\tO\nthe\tO\nClinical\tO\nGlobal\tO\nImpression\tO\n-\tO\nSexual\tO\nFunction\tO\n(\tO\nCGI\tO\n-\tO\nSF\tO\n;\tO\nthe\tO\nprimary\tO\noutcome\tO\nmeasure\tO\n)\tO\n,\tO\nthe\tO\nInternational\tO\nIndex\tO\nof\tO\nErectile\tO\nFunction\tO\n(\tO\nIIEF\tO\n)\tO\n,\tO\nArizona\tO\nSexual\tO\nExperience\tO\nScale\tO\n(\tO\nASEX\tO\n)\tO\n,\tO\nand\tO\nErectile\tB-Disease\nDysfunction\tI-Disease\nInventory\tO\nof\tO\nTreatment\tO\nSatisfaction\tO\n(\tO\nEDITS\tO\n)\tO\n(\tO\nsecondary\tO\noutcome\tO\nmeasures\tO\n)\tO\n.\tO\n\nParticipants\tO\nwere\tO\nfollowed\tO\nbiweekly\tO\nduring\tO\nstudy\tO\nperiod\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAfter\tO\n12\tO\nweeks\tO\nof\tO\ntreatment\tO\n,\tO\nthe\tO\nmean\tO\n(\tO\nsd\tO\n)\tO\nscores\tO\nfor\tO\nCGI\tO\n-\tO\nSF\tO\nwere\tO\nsignificantly\tO\nlower\tO\n,\tO\ni\tO\n.\tO\ne\tO\n.\tO\nbetter\tO\n,\tO\nin\tO\npatients\tO\non\tO\nbupropion\tB-Chemical\nSR\tO\n,\tO\nat\tO\n2\tO\n.\tO\n4\tO\n(\tO\n1\tO\n.\tO\n2\tO\n)\tO\n,\tO\nthan\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\n,\tO\nat\tO\n3\tO\n.\tO\n9\tO\n(\tO\n1\tO\n.\tO\n1\tO\n)\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nMen\tO\nwho\tO\nreceived\tO\nbupropion\tB-Chemical\nhad\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nthe\tO\ntotal\tO\nIIEF\tO\nscore\tO\n(\tO\n54\tO\n.\tO\n4\tO\n%\tO\nvs\tO\n1\tO\n.\tO\n2\tO\n%\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n003\tO\n)\tO\n,\tO\nand\tO\nin\tO\nthe\tO\nfive\tO\ndifferent\tO\ndomains\tO\nof\tO\nthe\tO\nIIEF\tO\n.\tO\n\nTotal\tO\nASEX\tO\nscores\tO\nwere\tO\nsignificantly\tO\nlower\tO\n,\tO\ni\tO\n.\tO\ne\tO\n.\tO\nbetter\tO\n,\tO\namong\tO\nmen\tO\nwho\tO\nreceived\tO\nbupropion\tB-Chemical\nthan\tO\nplacebo\tO\n,\tO\nat\tO\n15\tO\n.\tO\n5\tO\n(\tO\n4\tO\n.\tO\n3\tO\n)\tO\nvs\tO\n21\tO\n.\tO\n5\tO\n(\tO\n4\tO\n.\tO\n7\tO\n)\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nThe\tO\nEDITS\tO\nscores\tO\nwere\tO\n67\tO\n.\tO\n4\tO\n(\tO\n10\tO\n.\tO\n2\tO\n)\tO\nfor\tO\nthe\tO\nbupropion\tB-Chemical\nand\tO\n36\tO\n.\tO\n3\tO\n(\tO\n11\tO\n.\tO\n7\tO\n)\tO\nfor\tO\nthe\tO\nplacebo\tO\ngroup\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThe\tO\nASEX\tO\nscore\tO\nand\tO\nCGI\tO\n-\tO\nSF\tO\nscore\tO\nwere\tO\ncorrelated\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n003\tO\n)\tO\n.\tO\n\nIn\tO\nlinear\tO\nregression\tO\nanalyses\tO\nthe\tO\nCGI\tO\n-\tO\nSF\tO\nscore\tO\nwas\tO\nnot\tO\naffected\tO\nsignificantly\tO\nby\tO\nthe\tO\nduration\tO\nof\tO\nSD\tB-Disease\n,\tO\ntype\tO\nof\tO\nSSRI\tB-Chemical\nused\tO\nand\tO\nage\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nBupropion\tB-Chemical\nis\tO\nan\tO\neffective\tO\ntreatment\tO\nfor\tO\nmale\tO\nSD\tB-Disease\ninduced\tO\nby\tO\nSSRIs\tB-Chemical\n.\tO\n\nThese\tO\nresults\tO\nprovide\tO\nempirical\tO\nsupport\tO\nfor\tO\nconducting\tO\na\tO\nfurther\tO\nstudy\tO\nof\tO\nbupropion\tB-Chemical\n.\tO\n\nPrevention\tO\nof\tO\nseizures\tB-Disease\nand\tO\nreorganization\tO\nof\tO\nhippocampal\tO\nfunctions\tO\nby\tO\ntransplantation\tO\nof\tO\nbone\tO\nmarrow\tO\ncells\tO\nin\tO\nthe\tO\nacute\tO\nphase\tO\nof\tO\nexperimental\tO\nepilepsy\tB-Disease\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\ntherapeutic\tO\npotential\tO\nof\tO\nbone\tO\nmarrow\tO\nmononuclear\tO\ncells\tO\n(\tO\nBMCs\tO\n)\tO\nin\tO\na\tO\nmodel\tO\nof\tO\nepilepsy\tB-Disease\ninduced\tO\nby\tO\npilocarpine\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nBMCs\tO\nobtained\tO\nfrom\tO\ngreen\tO\nfluorescent\tO\nprotein\tO\n(\tO\nGFP\tO\n)\tO\ntransgenic\tO\nmice\tO\nor\tO\nrats\tO\nwere\tO\ntransplanted\tO\nintravenously\tO\nafter\tO\ninduction\tO\nof\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n(\tO\nSE\tB-Disease\n)\tO\n.\tO\n\nSpontaneous\tB-Disease\nrecurrent\tI-Disease\nseizures\tI-Disease\n(\tO\nSRS\tB-Disease\n)\tO\nwere\tO\nmonitored\tO\nusing\tO\nRacine\tO\n'\tO\ns\tO\nseizure\tB-Disease\nseverity\tO\nscale\tO\n.\tO\n\nAll\tO\nof\tO\nthe\tO\nrats\tO\nin\tO\nthe\tO\nsaline\tO\n-\tO\ntreated\tO\nepileptic\tB-Disease\ncontrol\tO\ngroup\tO\ndeveloped\tO\nSRS\tB-Disease\n,\tO\nwhereas\tO\nnone\tO\nof\tO\nthe\tO\nBMC\tO\n-\tO\ntreated\tO\nepileptic\tB-Disease\nanimals\tO\nhad\tO\nseizures\tB-Disease\nin\tO\nthe\tO\nshort\tO\nterm\tO\n(\tO\n15\tO\ndays\tO\nafter\tO\ntransplantation\tO\n)\tO\n,\tO\nregardless\tO\nof\tO\nthe\tO\nBMC\tO\nsource\tO\n.\tO\n\nOver\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nchronic\tO\nphase\tO\n(\tO\n120\tO\ndays\tO\nafter\tO\ntransplantation\tO\n)\tO\n,\tO\nonly\tO\n25\tO\n%\tO\nof\tO\nBMC\tO\n-\tO\ntreated\tO\nepileptic\tB-Disease\nanimals\tO\nhad\tO\nseizures\tB-Disease\n,\tO\nbut\tO\nwith\tO\na\tO\nlower\tO\nfrequency\tO\nand\tO\nduration\tO\ncompared\tO\nto\tO\nthe\tO\nepileptic\tB-Disease\ncontrol\tO\ngroup\tO\n.\tO\n\nThe\tO\ndensity\tO\nof\tO\nhippocampal\tO\nneurons\tO\nin\tO\nthe\tO\nbrains\tO\nof\tO\nanimals\tO\ntreated\tO\nwith\tO\nBMCs\tO\nwas\tO\nmarkedly\tO\npreserved\tO\n.\tO\n\nAt\tO\nhippocampal\tO\nSchaeffer\tO\ncollateral\tO\n-\tO\nCA1\tO\nsynapses\tO\n,\tO\nlong\tO\n-\tO\nterm\tO\npotentiation\tO\nwas\tO\npreserved\tO\nin\tO\nBMC\tO\n-\tO\ntransplanted\tO\nrats\tO\ncompared\tO\nto\tO\nepileptic\tB-Disease\ncontrols\tO\n.\tO\n\nThe\tO\ndonor\tO\n-\tO\nderived\tO\nGFP\tO\n(\tO\n+\tO\n)\tO\ncells\tO\nwere\tO\nrarely\tO\nfound\tO\nin\tO\nthe\tO\nbrains\tO\nof\tO\ntransplanted\tO\nepileptic\tB-Disease\nrats\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\ntreatment\tO\nwith\tO\nBMCs\tO\ncan\tO\nprevent\tO\nthe\tO\ndevelopment\tO\nof\tO\nchronic\tO\nseizures\tB-Disease\n,\tO\nreduce\tO\nneuronal\tB-Disease\nloss\tI-Disease\n,\tO\nand\tO\ninfluence\tO\nthe\tO\nreorganization\tO\nof\tO\nthe\tO\nhippocampal\tO\nneuronal\tO\nnetwork\tO\n.\tO\n\nNormalizing\tO\neffects\tO\nof\tO\nmodafinil\tB-Chemical\non\tO\nsleep\tO\nin\tO\nchronic\tO\ncocaine\tB-Chemical\nusers\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\neffect\tO\nof\tO\nmorning\tO\n-\tO\ndosed\tO\nmodafinil\tB-Chemical\non\tO\nsleep\tO\nand\tO\ndaytime\tB-Disease\nsleepiness\tI-Disease\nin\tO\nchronic\tO\ncocaine\tB-Chemical\nusers\tO\n.\tO\n\nMETHOD\tO\n:\tO\nTwenty\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tO\nparticipants\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nreceive\tO\nmodafinil\tB-Chemical\n,\tO\n400\tO\nmg\tO\n(\tO\nN\tO\n=\tO\n10\tO\n)\tO\n,\tO\nor\tO\nplacebo\tO\n(\tO\nN\tO\n=\tO\n10\tO\n)\tO\nevery\tO\nmorning\tO\nat\tO\n7\tO\n:\tO\n30\tO\na\tO\n.\tO\nm\tO\n.\tO\nfor\tO\n16\tO\ndays\tO\nin\tO\nan\tO\ninpatient\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\nrandomized\tO\ntrial\tO\n.\tO\n\nParticipants\tO\nunderwent\tO\npolysomnographic\tO\nsleep\tO\nrecordings\tO\non\tO\ndays\tO\n1\tO\nto\tO\n3\tO\n,\tO\n7\tO\nto\tO\n9\tO\n,\tO\nand\tO\n14\tO\nto\tO\n16\tO\n(\tO\nfirst\tO\n,\tO\nsecond\tO\n,\tO\nand\tO\nthird\tO\nweeks\tO\nof\tO\nabstinence\tO\n)\tO\n.\tO\n\nThe\tO\nMultiple\tO\nSleep\tO\nLatency\tO\nTest\tO\nwas\tO\nperformed\tO\nat\tO\n11\tO\n:\tO\n30\tO\na\tO\n.\tO\nm\tO\n.\tO\n,\tO\n2\tO\n:\tO\n00\tO\np\tO\n.\tO\nm\tO\n.\tO\n,\tO\nand\tO\n4\tO\n:\tO\n30\tO\np\tO\n.\tO\nm\tO\n.\tO\non\tO\ndays\tO\n2\tO\n,\tO\n8\tO\n,\tO\nand\tO\n15\tO\n.\tO\n\nFor\tO\ncomparison\tO\nof\tO\nsleep\tO\narchitecture\tO\nvariables\tO\n,\tO\n12\tO\nhealthy\tO\ncomparison\tO\nparticipants\tO\nunderwent\tO\na\tO\nsingle\tO\nnight\tO\nof\tO\nexperimental\tO\npolysomnography\tO\nthat\tO\nfollowed\tO\n1\tO\nnight\tO\nof\tO\naccommodation\tO\npolysomnography\tO\n.\tO\n\nRESULTS\tO\n:\tO\nProgressive\tO\nabstinence\tO\nfrom\tO\ncocaine\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\nworsening\tO\nof\tO\nall\tO\nmeasured\tO\npolysomnographic\tO\nsleep\tO\noutcomes\tO\n.\tO\n\nCompared\tO\nwith\tO\nplacebo\tO\n,\tO\nmodafinil\tB-Chemical\ndecreased\tO\nnighttime\tO\nsleep\tO\nlatency\tO\nand\tO\nincreased\tO\nslow\tO\n-\tO\nwave\tO\nsleep\tO\ntime\tO\nin\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tO\nparticipants\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nmodafinil\tB-Chemical\ninteracted\tO\nwith\tO\nthe\tO\nabstinence\tO\nweek\tO\nand\tO\nwas\tO\nassociated\tO\nwith\tO\nlonger\tO\ntotal\tO\nsleep\tO\ntime\tO\nand\tO\nshorter\tO\nREM\tO\nsleep\tO\nlatency\tO\nin\tO\nthe\tO\nthird\tO\nweek\tO\nof\tO\nabstinence\tO\n.\tO\n\nComparison\tO\nof\tO\nslow\tO\n-\tO\nwave\tO\nsleep\tO\ntime\tO\n,\tO\ntotal\tO\nsleep\tO\ntime\tO\n,\tO\nand\tO\nsleep\tO\nlatency\tO\nin\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tO\nand\tO\nhealthy\tO\nparticipants\tO\nrevealed\tO\na\tO\nnormalizing\tO\neffect\tO\nof\tO\nmodafinil\tB-Chemical\nin\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tO\nparticipants\tO\n.\tO\n\nModafinil\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\nincreased\tO\ndaytime\tO\nsleep\tO\nlatency\tO\n,\tO\nas\tO\nmeasured\tO\nby\tO\nthe\tO\nMultiple\tO\nSleep\tO\nLatency\tO\nTest\tO\n,\tO\nand\tO\na\tO\nnearly\tO\nsignificant\tO\ndecrease\tO\nin\tO\nsubjective\tO\ndaytime\tB-Disease\nsleepiness\tI-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nMorning\tO\n-\tO\ndosed\tO\nmodafinil\tB-Chemical\npromotes\tO\nnocturnal\tO\nsleep\tO\n,\tO\nnormalizes\tO\nsleep\tO\narchitecture\tO\n,\tO\nand\tO\ndecreases\tO\ndaytime\tB-Disease\nsleepiness\tI-Disease\nin\tO\nabstinent\tO\ncocaine\tB-Chemical\nusers\tO\n.\tO\n\nThese\tO\neffects\tO\nmay\tO\nbe\tO\nrelevant\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\ncocaine\tB-Chemical\ndependence\tO\n.\tO\n\nSafety\tO\nof\tO\ntransesophageal\tO\nechocardiography\tO\nin\tO\nadults\tO\n:\tO\nstudy\tO\nin\tO\na\tO\nmultidisciplinary\tO\nhospital\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nTEE\tO\nis\tO\na\tO\nsemi\tO\n-\tO\ninvasive\tO\ntool\tO\nbroadly\tO\nused\tO\nand\tO\nits\tO\nutilization\tO\nassociated\tO\nto\tO\nsedatives\tO\ndrugs\tO\nmight\tO\nto\tO\naffect\tO\nthe\tO\nprocedure\tO\nsafety\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nto\tO\nanalyze\tO\naspects\tO\nof\tO\nTEE\tO\nsafety\tO\nassociated\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\nMidazolan\tB-Chemical\n(\tO\nMZ\tB-Chemical\n)\tO\nand\tO\nFlumazenil\tB-Chemical\n(\tO\nFL\tB-Chemical\n)\tO\nand\tO\nthe\tO\ninfluence\tO\nof\tO\nthe\tO\nclinical\tO\nvariables\tO\non\tO\nthe\tO\nevent\tO\nrate\tO\n.\tO\n\nMETHOD\tO\n:\tO\nprospective\tO\nstudy\tO\nwith\tO\n137\tO\npatients\tO\nthat\tO\nunderwent\tO\nTEE\tO\nwith\tO\nMZ\tB-Chemical\nassociated\tO\nto\tO\nmoderate\tO\nsedation\tO\n.\tO\n\nWe\tO\nanalyzed\tO\nthe\tO\nfollowing\tO\nevents\tO\n:\tO\ncomplications\tO\nrelated\tO\nwith\tO\nthe\tO\ntopical\tO\nanesthesia\tO\n,\tO\nwith\tO\nMZ\tB-Chemical\nuse\tO\nand\tO\nwith\tO\nthe\tO\nprocedure\tO\n.\tO\n\nUni\tO\n-\tO\nand\tO\nmultivariate\tO\nanalyses\tO\nwere\tO\nused\tO\nto\tO\ntest\tO\nthe\tO\ninfluence\tO\nof\tO\nthe\tO\nclinical\tO\nvariables\tO\n:\tO\nage\tO\n,\tO\nsex\tO\n,\tO\nstroke\tB-Disease\n,\tO\nmyocardiopathy\tB-Disease\n(\tO\nMP\tB-Disease\n)\tO\n,\tO\nduration\tO\nof\tO\nthe\tO\ntest\tO\n,\tO\nmitral\tB-Disease\nregurgitation\tI-Disease\n(\tO\nMR\tB-Disease\n)\tO\nand\tO\nthe\tO\nMZ\tB-Chemical\ndose\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\npatients\tO\n(\tO\n65\tO\n+\tO\n/\tO\n-\tO\n16\tO\nyrs\tO\n;\tO\n58\tO\n%\tO\nmales\tO\n)\tO\nfinished\tO\nthe\tO\nexamination\tO\n.\tO\n\nThe\tO\nmean\tO\ndoses\tO\nof\tO\nMZ\tB-Chemical\nand\tO\nFL\tB-Chemical\nwere\tO\n4\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n9\tO\nmg\tO\nand\tO\n0\tO\n.\tO\n28\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\nmg\tO\n,\tO\nrespectively\tO\n.\tO\n\nThe\tO\nduration\tO\nof\tO\nthe\tO\nexamination\tO\nand\tO\nthe\tO\nmean\tO\nejection\tO\nfraction\tO\n(\tO\nEF\tO\n)\tO\nwere\tO\n16\tO\n.\tO\n4\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n1\tO\nminutes\tO\nand\tO\n60\tO\n+\tO\n/\tO\n-\tO\n9\tO\n%\tO\n,\tO\nrespectively\tO\n.\tO\n\nMild\tO\nhypoxia\tB-Disease\n(\tO\nSO2\tO\n<\tO\n90\tO\n%\tO\n)\tO\nwas\tO\nthe\tO\nmost\tO\ncommon\tO\nevent\tO\n(\tO\n11\tO\npatients\tO\n)\tO\n;\tO\n3\tO\npatients\tO\n(\tO\n2\tO\n%\tO\n)\tO\npresented\tO\ntransient\tO\nhypoxia\tB-Disease\ndue\tO\nto\tO\nupper\tO\nairway\tB-Disease\nobstruction\tI-Disease\nby\tO\nprobe\tO\nintroduction\tO\nand\tO\n8\tO\n(\tO\n5\tO\n.\tO\n8\tO\n%\tO\n)\tO\ndue\tO\nto\tO\nhypoxia\tB-Disease\ncaused\tO\nby\tO\nMZ\tB-Chemical\nuse\tO\n.\tO\n\nTransient\tO\nhypotension\tB-Disease\n(\tO\nSAP\tO\n<\tO\n90mmHg\tO\n)\tO\noccurred\tO\nin\tO\n1\tO\npatient\tO\n(\tO\n0\tO\n.\tO\n7\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmultivariate\tO\nanalysis\tO\nshowed\tO\nthat\tO\nsevere\tO\nMR\tB-Disease\n,\tO\nMP\tB-Disease\n(\tO\nEF\tO\n<\tO\n45\tO\n%\tO\n)\tO\nand\tO\nhigh\tO\ndoses\tO\nof\tO\nMZ\tB-Chemical\n(\tO\n>\tO\n5mg\tO\n)\tO\nwere\tO\nassociated\tO\nwith\tO\nevents\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nThe\tO\nEF\tO\nwas\tO\n40\tO\n%\tO\n,\tO\nin\tO\nthe\tO\ngroup\tO\nwith\tO\nMP\tB-Disease\nand\tO\n44\tO\n%\tO\nin\tO\nthe\tO\ngroup\tO\nwith\tO\nsevere\tO\nMR\tB-Disease\nand\tO\nit\tO\ncan\tO\nbe\tO\na\tO\nfactor\tO\nassociated\tO\nwith\tO\nclinical\tO\nevents\tO\nin\tO\nthe\tO\nlast\tO\ngroup\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nTEE\tO\nwith\tO\nsedation\tO\npresents\tO\na\tO\nlow\tO\nrate\tO\nof\tO\nevents\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nsevere\tO\nevents\tO\nand\tO\nthere\tO\nwas\tO\nno\tO\nneed\tO\nto\tO\ninterrupt\tO\nthe\tO\nexaminations\tO\n.\tO\n\nEffect\tO\nof\tO\ndirect\tO\nintracoronary\tO\nadministration\tO\nof\tO\nmethylergonovine\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nand\tO\nwithout\tO\nvariant\tB-Disease\nangina\tI-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nintracoronary\tO\nadministration\tO\nof\tO\nmethylergonovine\tB-Chemical\nwere\tO\nstudied\tO\nin\tO\n21\tO\npatients\tO\nwith\tO\nvariant\tB-Disease\nangina\tI-Disease\nand\tO\n22\tO\npatients\tO\nwith\tO\natypical\tO\nchest\tB-Disease\npain\tI-Disease\nand\tO\nin\tO\nothers\tO\nwithout\tO\nangina\tB-Disease\npectoris\tI-Disease\n(\tO\ncontrol\tO\ngroup\tO\n)\tO\n.\tO\n\nMethylergonovine\tB-Chemical\nwas\tO\nadministered\tO\ncontinuously\tO\nat\tO\na\tO\nrate\tO\nof\tO\n10\tO\nmicrograms\tO\n/\tO\nmin\tO\nup\tO\nto\tO\n50\tO\nmicrograms\tO\n.\tO\n\nIn\tO\nall\tO\npatients\tO\nwith\tO\nvariant\tB-Disease\nangina\tI-Disease\n,\tO\ncoronary\tB-Disease\nspasm\tI-Disease\nwas\tO\nprovoked\tO\nat\tO\na\tO\nmean\tO\ndose\tO\nof\tO\n28\tO\n+\tO\n/\tO\n-\tO\n13\tO\nmicrograms\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\ncontrol\tO\ngroup\tO\nneither\tO\nischemic\tO\nST\tO\nchange\tO\nnor\tO\nlocalized\tO\nspasm\tB-Disease\noccurred\tO\n.\tO\n\nThe\tO\nbasal\tO\ntone\tO\nof\tO\nthe\tO\nright\tO\ncoronary\tO\nartery\tO\nwas\tO\nsignificantly\tO\nlower\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\nleft\tO\ncoronary\tO\nartery\tO\n.\tO\n\nThe\tO\npercentage\tO\nof\tO\nvasoconstriction\tO\nof\tO\nthe\tO\nright\tO\ncoronary\tO\nartery\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\nleft\tO\ncoronary\tO\nartery\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nspasm\tB-Disease\nprovocation\tO\ntests\tO\n,\tO\nwhich\tO\nuse\tO\nan\tO\nintracoronary\tO\ninjection\tO\nof\tO\na\tO\nrelatively\tO\nlow\tO\ndose\tO\nof\tO\nmethylergonovine\tB-Chemical\n,\tO\nhave\tO\na\tO\nhigh\tO\nsensitivity\tO\nin\tO\nvariant\tB-Disease\nangina\tI-Disease\nand\tO\nthe\tO\nvasoreactivity\tO\nof\tO\nthe\tO\nright\tO\ncoronary\tO\nartery\tO\nmay\tO\nbe\tO\ngreater\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\nother\tO\ncoronary\tO\narteries\tO\n.\tO\n\nOral\tO\nmanifestations\tO\nof\tO\n\"\tO\nmeth\tB-Disease\nmouth\tI-Disease\n\"\tO\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nAIM\tO\n:\tO\nThe\tO\naim\tO\nof\tO\nthe\tO\ndocumentation\tO\nof\tO\nthis\tO\nclinical\tO\ncase\tO\nis\tO\nto\tO\nmake\tO\nclinicians\tO\naware\tO\nof\tO\n\"\tO\nmeth\tB-Disease\nmouth\tI-Disease\n\"\tO\nand\tO\nthe\tO\nmedical\tO\nrisks\tO\nassociated\tO\nwith\tO\nthis\tO\nserious\tO\ncondition\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nMethamphetamine\tB-Chemical\nis\tO\na\tO\nvery\tO\naddictive\tO\n,\tO\npowerful\tO\nstimulant\tO\nthat\tO\nincreases\tO\nwakefulness\tO\nand\tO\nphysical\tO\nactivity\tO\nand\tO\ncan\tO\nproduce\tO\nother\tO\neffects\tO\nsuch\tO\nas\tO\ncardiac\tB-Disease\ndysrhythmias\tI-Disease\n,\tO\nhypertension\tB-Disease\n,\tO\nhallucinations\tB-Disease\n,\tO\nand\tO\nviolent\tB-Disease\nbehavior\tI-Disease\n.\tO\n\nDental\tO\npatients\tO\nabusing\tO\nmethamphetamine\tB-Chemical\ncan\tO\npresent\tO\nwith\tO\npoor\tO\noral\tO\nhygiene\tO\n,\tO\nxerostomia\tB-Disease\n,\tO\nrampant\tO\ncaries\tB-Disease\n(\tO\n\"\tO\nmeth\tB-Disease\nmouth\tI-Disease\n\"\tO\n)\tO\n,\tO\nand\tO\nexcessive\tO\ntooth\tB-Disease\nwear\tI-Disease\n.\tO\n\nOral\tO\nrehabilitation\tO\nof\tO\npatients\tO\nusing\tO\nmethamphetamine\tB-Chemical\ncan\tO\nbe\tO\nchallenging\tO\n.\tO\n\nCASE\tO\nDESCRIPTION\tO\n:\tO\nA\tO\n30\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nCaucasian\tO\nwoman\tO\npresented\tO\nwith\tO\ndental\tO\npain\tB-Disease\n,\tO\nbad\tB-Disease\nbreath\tI-Disease\n,\tO\nand\tO\nself\tO\n-\tO\nreported\tO\npoor\tO\nesthetics\tO\n.\tO\n\nA\tO\ncomprehensive\tO\nexamination\tO\nincluding\tO\nher\tO\nmedical\tO\nhistory\tO\n,\tO\npanoramic\tO\nradiograph\tO\n,\tO\nand\tO\nintraoral\tO\nexamination\tO\nrevealed\tO\n19\tO\ncarious\tB-Disease\nlesions\tI-Disease\n,\tO\nwhich\tO\nis\tO\nnot\tO\nvery\tO\ncommon\tO\nfor\tO\na\tO\nhealthy\tO\nadult\tO\n.\tO\n\nShe\tO\nreported\tO\nher\tO\nuse\tO\nof\tO\nmethamphetamine\tB-Chemical\nfor\tO\nfive\tO\nyears\tO\nand\tO\nhad\tO\nnot\tO\nexperienced\tO\nany\tO\nmajor\tO\ncarious\tB-Disease\nepisodes\tI-Disease\nbefore\tO\nshe\tO\nstarted\tO\nusing\tO\nthe\tO\ndrug\tO\n.\tO\n\nSUMMARY\tO\n:\tO\nThe\tO\npatient\tO\n'\tO\ns\tO\nmedical\tO\nand\tO\ndental\tO\nhistories\tO\nalong\tO\nwith\tO\nradiographic\tO\nand\tO\nclinical\tO\nfindings\tO\nlead\tO\nto\tO\na\tO\ndiagnosis\tO\nof\tO\n\"\tO\nmeth\tB-Disease\nmouth\tI-Disease\n.\tO\n\"\tO\nAlthough\tO\nthree\tO\ndifferent\tO\ndental\tO\ntreatment\tO\nmodalities\tO\n(\tO\neither\tO\nconventional\tO\nor\tO\nimplant\tO\n-\tO\nsupported\tO\n)\tO\nhave\tO\nbeen\tO\noffered\tO\nto\tO\nthe\tO\npatient\tO\nsince\tO\nAugust\tO\n2007\tO\n,\tO\nthe\tO\npatient\tO\nhas\tO\nyet\tO\nto\tO\ninitiate\tO\nany\tO\ntreatment\tO\n.\tO\n\nCLINICAL\tO\nSIGNIFICANCE\tO\n:\tO\nThis\tO\nclinical\tO\ncase\tO\nshowing\tO\noral\tO\nmanifestations\tO\nof\tO\nmeth\tB-Disease\nmouth\tI-Disease\nwas\tO\npresented\tO\nto\tO\nhelp\tO\ndental\tO\npractitioners\tO\nrecognize\tO\nand\tO\nmanage\tO\npatients\tO\nwho\tO\nmay\tO\nbe\tO\nabusing\tO\nmethamphetamines\tB-Chemical\n.\tO\n\nDental\tO\npractitioners\tO\nalso\tO\nmay\tO\nbe\tO\nskeptical\tO\nabout\tO\nthe\tO\nreliability\tO\nof\tO\nappointment\tO\nkeeping\tO\nby\tO\nthese\tO\npatients\tO\n,\tO\nas\tO\nthey\tO\nfrequently\tO\nmiss\tO\ntheir\tO\nappointments\tO\nwithout\tO\nreasonable\tO\njustification\tO\n.\tO\n\nAntituberculosis\tB-Chemical\ntherapy\tO\n-\tO\ninduced\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n:\tO\nmagnitude\tO\n,\tO\nprofile\tO\n,\tO\nprognosis\tO\n,\tO\nand\tO\npredictors\tO\nof\tO\noutcome\tO\n.\tO\n\nAntituberculosis\tB-Chemical\ntherapy\tO\n(\tO\nATT\tO\n)\tO\n-\tO\nassociated\tO\nacute\tB-Disease\nliver\tI-Disease\nfailure\tI-Disease\n(\tO\nATT\tO\n-\tO\nALF\tB-Disease\n)\tO\nis\tO\nthe\tO\ncommonest\tO\ndrug\tO\n-\tO\ninduced\tO\nALF\tB-Disease\nin\tO\nSouth\tO\nAsia\tO\n.\tO\n\nProspective\tO\nstudies\tO\non\tO\nATT\tO\n-\tO\nALF\tB-Disease\nare\tO\nlacking\tO\n.\tO\n\nThe\tO\ncurrent\tO\nstudy\tO\nprospectively\tO\nevaluated\tO\nthe\tO\nmagnitude\tO\n,\tO\nclinical\tO\ncourse\tO\n,\tO\noutcome\tO\n,\tO\nand\tO\nprognostic\tO\nfactors\tO\nin\tO\nATT\tO\n-\tO\nALF\tB-Disease\n.\tO\n\nFrom\tO\nJanuary\tO\n1986\tO\nto\tO\nJanuary\tO\n2009\tO\n,\tO\n1223\tO\nconsecutive\tO\nALF\tB-Disease\npatients\tO\nwere\tO\nevaluated\tO\n:\tO\nATT\tO\nalone\tO\nwas\tO\nthe\tO\ncause\tO\nin\tO\n70\tO\n(\tO\n5\tO\n.\tO\n7\tO\n%\tO\n)\tO\npatients\tO\n.\tO\n\nAnother\tO\n15\tO\n(\tO\n1\tO\n.\tO\n2\tO\n%\tO\n)\tO\nhad\tO\nATT\tO\nand\tO\nsimultaneous\tO\nhepatitis\tB-Disease\nvirus\tI-Disease\ninfection\tI-Disease\n.\tO\n\nIn\tO\n44\tO\n(\tO\n62\tO\n.\tO\n8\tO\n%\tO\n)\tO\npatients\tO\n,\tO\nATT\tO\nwas\tO\nprescribed\tO\nempirically\tO\nwithout\tO\ndefinitive\tO\nevidence\tO\nof\tO\ntuberculosis\tB-Disease\n.\tO\n\nATT\tO\n-\tO\nALF\tB-Disease\npatients\tO\nwere\tO\nyounger\tO\n(\tO\n32\tO\n.\tO\n87\tO\n[\tO\n+\tO\n/\tO\n-\tO\n15\tO\n.\tO\n8\tO\n]\tO\nyears\tO\n)\tO\n,\tO\nand\tO\n49\tO\n(\tO\n70\tO\n%\tO\n)\tO\nof\tO\nthem\tO\nwere\tO\nwomen\tO\n.\tO\n\nMost\tO\nhad\tO\nhyperacute\tO\npresentation\tO\n;\tO\nthe\tO\nmedian\tO\nicterus\tB-Disease\nencephalopathy\tB-Disease\ninterval\tO\nwas\tO\n4\tO\n.\tO\n5\tO\n(\tO\n0\tO\n-\tO\n30\tO\n)\tO\ndays\tO\n.\tO\n\nThe\tO\nmedian\tO\nduration\tO\nof\tO\nATT\tO\nbefore\tO\nALF\tB-Disease\nwas\tO\n30\tO\n(\tO\n7\tO\n-\tO\n350\tO\n)\tO\ndays\tO\n.\tO\n\nAt\tO\npresentation\tO\n,\tO\nadvanced\tO\nencephalopathy\tB-Disease\nand\tO\ncerebral\tB-Disease\nedema\tI-Disease\nwere\tO\npresent\tO\nin\tO\n51\tO\n(\tO\n76\tO\n%\tO\n)\tO\nand\tO\n29\tO\n(\tO\n41\tO\n.\tO\n4\tO\n%\tO\n)\tO\npatients\tO\n,\tO\nrespectively\tO\n.\tO\n\nGastrointestinal\tB-Disease\nbleed\tI-Disease\n,\tO\nseizures\tB-Disease\n,\tO\ninfection\tB-Disease\n,\tO\nand\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nwere\tO\ndocumented\tO\nin\tO\nseven\tO\n(\tO\n10\tO\n%\tO\n)\tO\n,\tO\nfive\tO\n(\tO\n7\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\n26\tO\n(\tO\n37\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nand\tO\nseven\tO\n(\tO\n10\tO\n%\tO\n)\tO\npatients\tO\n,\tO\nrespectively\tO\n.\tO\n\nCompared\tO\nwith\tO\nhepatitis\tB-Disease\nE\tI-Disease\nvirus\tO\n(\tO\nHEV\tO\n)\tO\nand\tO\nnon\tO\n-\tO\nA\tO\nnon\tO\n-\tO\nE\tO\n-\tO\ninduced\tO\nALF\tB-Disease\n,\tO\nATT\tO\n-\tO\nALF\tB-Disease\npatients\tO\nhad\tO\nnearly\tO\nsimilar\tO\npresentations\tO\nexcept\tO\nfor\tO\nolder\tO\nage\tO\nand\tO\nless\tO\nelevation\tO\nof\tO\nliver\tO\nenzymes\tO\n.\tO\n\nThe\tO\nmortality\tO\nrate\tO\namong\tO\npatients\tO\nwith\tO\nATT\tO\n-\tO\nALF\tB-Disease\nwas\tO\nhigh\tO\n(\tO\n67\tO\n.\tO\n1\tO\n%\tO\n,\tO\nn\tO\n=\tO\n47\tO\n)\tO\n,\tO\nand\tO\nonly\tO\n23\tO\n(\tO\n32\tO\n.\tO\n9\tO\n%\tO\n)\tO\npatients\tO\nrecovered\tO\nwith\tO\nmedical\tO\ntreatment\tO\n.\tO\n\nIn\tO\nmultivariate\tO\nanalysis\tO\n,\tO\nthree\tO\nfactors\tO\nindependently\tO\npredicted\tO\nmortality\tO\n:\tO\nserum\tO\nbilirubin\tB-Chemical\n(\tO\n>\tO\nor\tO\n=\tO\n10\tO\n.\tO\n8\tO\nmg\tO\n/\tO\ndL\tO\n)\tO\n,\tO\nprothrombin\tO\ntime\tO\n(\tO\nPT\tO\n)\tO\nprolongation\tO\n(\tO\n>\tO\nor\tO\n=\tO\n26\tO\nseconds\tO\n)\tO\n,\tO\nand\tO\ngrade\tO\nIII\tO\n/\tO\nIV\tO\nencephalopathy\tB-Disease\nat\tO\npresentation\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nATT\tO\n-\tO\nALF\tB-Disease\nconstituted\tO\n5\tO\n.\tO\n7\tO\n%\tO\nof\tO\nALF\tB-Disease\nat\tO\nour\tO\ncenter\tO\nand\tO\nhad\tO\na\tO\nhigh\tO\nmortality\tO\nrate\tO\n.\tO\n\nBecause\tO\nthe\tO\nmortality\tO\nrate\tO\nis\tO\nso\tO\nhigh\tO\n,\tO\ndetermining\tO\nwhich\tO\nfactors\tO\nare\tO\npredictors\tO\nis\tO\nless\tO\nimportant\tO\n.\tO\n\nA\tO\nhigh\tO\nproportion\tO\nof\tO\npatients\tO\nhad\tO\nconsumed\tO\nATT\tO\nempirically\tO\n,\tO\nwhich\tO\ncould\tO\nhave\tO\nbeen\tO\nprevented\tO\n.\tO\n\nDesign\tO\nand\tO\nanalysis\tO\nof\tO\nthe\tO\nHYPREN\tO\n-\tO\ntrial\tO\n:\tO\nsafety\tO\nof\tO\nenalapril\tB-Chemical\nand\tO\nprazosin\tB-Chemical\nin\tO\nthe\tO\ninitial\tO\ntreatment\tO\nphase\tO\nof\tO\npatients\tO\nwith\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n.\tO\n\nSince\tO\nthe\tO\nintroduction\tO\nof\tO\nangiotensin\tB-Chemical\nconverting\tI-Chemical\nenzyme\tI-Chemical\n(\tI-Chemical\nACE\tI-Chemical\n)\tI-Chemical\ninhibitors\tI-Chemical\ninto\tO\nthe\tO\nadjunctive\tO\ntreatment\tO\nof\tO\npatients\tO\nwith\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\n,\tO\ncases\tO\nof\tO\nsevere\tO\nhypotension\tB-Disease\n,\tO\nespecially\tO\non\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\ntreatment\tO\n,\tO\nhave\tO\noccasionally\tO\nbeen\tO\nreported\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nsafety\tO\nof\tO\nthe\tO\nACE\tB-Chemical\ninhibitor\tI-Chemical\nenalapril\tB-Chemical\na\tO\nmulticenter\tO\n,\tO\nrandomized\tO\n,\tO\nprazosin\tB-Chemical\n-\tO\ncontrolled\tO\ntrial\tO\nwas\tO\ndesigned\tO\nthat\tO\ncompared\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nsymptomatic\tO\nhypotension\tB-Disease\non\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\ntreatment\tO\n.\tO\n\nTrial\tO\nmedication\tO\nwas\tO\n2\tO\n.\tO\n5\tO\nmg\tO\nenalapril\tB-Chemical\nor\tO\n0\tO\n.\tO\n5\tO\nprazosin\tB-Chemical\n.\tO\n\nSubjects\tO\nwere\tO\n1210\tO\ninpatients\tO\nwith\tO\nNew\tO\nYork\tO\nHeart\tO\nAssociation\tO\n(\tO\nNYHA\tO\n)\tO\nfunctional\tO\nclass\tO\nII\tO\nand\tO\nIII\tO\n.\tO\n\nPatients\tO\nwho\tO\nreceived\tO\nenalapril\tB-Chemical\nexperienced\tO\nclinically\tO\nand\tO\nstatistically\tO\nsignificantly\tO\nless\tO\nsymptomatic\tO\nhypotension\tB-Disease\n(\tO\n5\tO\n.\tO\n2\tO\n%\tO\n)\tO\nthan\tO\nthe\tO\npatients\tO\nwho\tO\nreceived\tO\nprazosin\tB-Chemical\n(\tO\n12\tO\n.\tO\n9\tO\n%\tO\n)\tO\n.\tO\n\nAll\tO\npatients\tO\nrecovered\tO\n.\tO\n\nIt\tO\nwas\tO\nconcluded\tO\nthat\tO\ntreatment\tO\nwith\tO\nenalapril\tB-Chemical\nwas\tO\nwell\tO\ntolerated\tO\nand\tO\nit\tO\nis\tO\n,\tO\ntherefore\tO\n,\tO\nunreasonable\tO\nto\tO\nrestrict\tO\nthe\tO\ninitiation\tO\nof\tO\ntreatment\tO\nwith\tO\nenalapril\tB-Chemical\nto\tO\ninpatients\tO\n.\tO\n\nCentral\tB-Disease\nnervous\tI-Disease\nsystem\tI-Disease\ncomplications\tI-Disease\nduring\tO\ntreatment\tO\nof\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\nin\tO\na\tO\nsingle\tO\npediatric\tO\ninstitution\tO\n.\tO\n\nCentral\tB-Disease\nnervous\tI-Disease\nsystem\tI-Disease\n(\tI-Disease\nCNS\tI-Disease\n)\tI-Disease\ncomplications\tI-Disease\nduring\tO\ntreatment\tO\nof\tO\nchildhood\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\n(\tO\nALL\tB-Disease\n)\tO\nremain\tO\na\tO\nchallenging\tO\nclinical\tO\nproblem\tO\n.\tO\n\nOutcome\tO\nimprovement\tO\nwith\tO\nmore\tO\nintensive\tO\nchemotherapy\tO\nhas\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nadverse\tO\nevents\tO\n.\tO\n\nThis\tO\nstudy\tO\nanalyzed\tO\nthe\tO\nincidence\tO\nof\tO\nneurological\tB-Disease\ncomplications\tI-Disease\nduring\tO\nALL\tB-Disease\ntreatment\tO\nin\tO\na\tO\nsingle\tO\npediatric\tO\ninstitution\tO\n,\tO\nfocusing\tO\non\tO\nclinical\tO\n,\tO\nradiological\tO\n,\tO\nand\tO\nelectrophysiological\tO\nfindings\tO\n.\tO\n\nExclusion\tO\ncriteria\tO\nincluded\tO\nCNS\tO\nleukemic\tB-Disease\ninfiltration\tI-Disease\nat\tO\ndiagnosis\tO\n,\tO\ntherapy\tO\n-\tO\nrelated\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\n,\tO\nlate\tO\n-\tO\nonset\tO\nencephalopathy\tB-Disease\n,\tO\nor\tO\nlong\tO\n-\tO\nterm\tO\nneurocognitive\tB-Disease\ndefects\tI-Disease\n.\tO\n\nDuring\tO\na\tO\n9\tO\n-\tO\nyear\tO\nperiod\tO\n,\tO\nwe\tO\nretrospectively\tO\ncollected\tO\n27\tO\nneurological\tO\nevents\tO\n(\tO\n11\tO\n%\tO\n)\tO\nin\tO\nas\tO\nmany\tO\npatients\tO\n,\tO\nfrom\tO\n253\tO\nchildren\tO\nenrolled\tO\nin\tO\nthe\tO\nALL\tB-Disease\nfront\tO\n-\tO\nline\tO\nprotocol\tO\n.\tO\n\nCNS\tO\ncomplications\tO\nincluded\tO\nposterior\tO\nreversible\tO\nleukoencephalopathy\tB-Disease\nsyndrome\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\n,\tO\nstroke\tB-Disease\n(\tO\nn\tO\n=\tO\n5\tO\n)\tO\n,\tO\ntemporal\tB-Disease\nlobe\tI-Disease\nepilepsy\tI-Disease\n(\tO\nn\tO\n=\tO\n2\tO\n)\tO\n,\tO\nhigh\tO\n-\tO\ndose\tO\nmethotrexate\tB-Chemical\ntoxicity\tB-Disease\n(\tO\nn\tO\n=\tO\n2\tO\n)\tO\n,\tO\nsyndrome\tO\nof\tO\ninappropriate\tB-Disease\nantidiuretic\tI-Disease\nhormone\tI-Disease\nsecretion\tI-Disease\n(\tO\nn\tO\n=\tO\n1\tO\n)\tO\n,\tO\nand\tO\nother\tO\nunclassified\tO\nevents\tO\n(\tO\nn\tO\n=\tO\n7\tO\n)\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nCNS\tO\ncomplications\tO\nare\tO\nfrequent\tO\nevents\tO\nduring\tO\nALL\tB-Disease\ntherapy\tO\n,\tO\nand\tO\nrequire\tO\nrapid\tO\ndetection\tO\nand\tO\nprompt\tO\ntreatment\tO\nto\tO\nlimit\tO\npermanent\tO\ndamage\tO\n.\tO\n\nCocaine\tB-Chemical\ncauses\tO\nmemory\tB-Disease\nand\tI-Disease\nlearning\tI-Disease\nimpairments\tI-Disease\nin\tO\nrats\tO\n:\tO\ninvolvement\tO\nof\tO\nnuclear\tO\nfactor\tO\nkappa\tO\nB\tO\nand\tO\noxidative\tO\nstress\tO\n,\tO\nand\tO\nprevention\tO\nby\tO\ntopiramate\tB-Chemical\n.\tO\n\nDifferent\tO\nmechanisms\tO\nhave\tO\nbeen\tO\nsuggested\tO\nfor\tO\ncocaine\tB-Chemical\ntoxicity\tB-Disease\nincluding\tO\nan\tO\nincrease\tO\nin\tO\noxidative\tO\nstress\tO\nbut\tO\nthe\tO\nassociation\tO\nbetween\tO\noxidative\tO\nstatus\tO\nin\tO\nthe\tO\nbrain\tO\nand\tO\ncocaine\tB-Chemical\ninduced\tO\n-\tO\nbehaviour\tO\nis\tO\npoorly\tO\nunderstood\tO\n.\tO\n\nNuclear\tO\nfactor\tO\nkappa\tO\nB\tO\n(\tO\nNFkappaB\tO\n)\tO\nis\tO\na\tO\nsensor\tO\nof\tO\noxidative\tO\nstress\tO\nand\tO\nparticipates\tO\nin\tO\nmemory\tO\nformation\tO\nthat\tO\ncould\tO\nbe\tO\ninvolved\tO\nin\tO\ndrug\tO\ntoxicity\tB-Disease\nand\tO\naddiction\tO\nmechanisms\tO\n.\tO\n\nTherefore\tO\nNFkappaB\tO\nactivity\tO\n,\tO\noxidative\tO\nstress\tO\n,\tO\nneuronal\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsynthase\tO\n(\tO\nnNOS\tO\n)\tO\nactivity\tO\n,\tO\nspatial\tO\nlearning\tO\nand\tO\nmemory\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\neffect\tO\nof\tO\ntopiramate\tB-Chemical\n,\tO\na\tO\npreviously\tO\nproposed\tO\ntherapy\tO\nfor\tO\ncocaine\tB-Disease\naddiction\tI-Disease\n,\tO\nwere\tO\nevaluated\tO\nin\tO\nan\tO\nexperimental\tO\nmodel\tO\nof\tO\ncocaine\tB-Chemical\nadministration\tO\nin\tO\nrats\tO\n.\tO\n\nNFkappaB\tO\nactivity\tO\nwas\tO\ndecreased\tO\nin\tO\nthe\tO\nfrontal\tO\ncortex\tO\nof\tO\ncocaine\tB-Chemical\ntreated\tO\nrats\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nGSH\tB-Chemical\nconcentration\tO\nand\tO\nglutathione\tB-Chemical\nperoxidase\tO\nactivity\tO\nin\tO\nthe\tO\nhippocampus\tO\n,\tO\nwhereas\tO\nnNOS\tO\nactivity\tO\nin\tO\nthe\tO\nhippocampus\tO\nwas\tO\nincreased\tO\n.\tO\n\nMemory\tO\nretrieval\tO\nof\tO\nexperiences\tO\nacquired\tO\nprior\tO\nto\tO\ncocaine\tB-Chemical\nadministration\tO\nwas\tO\nimpaired\tO\nand\tO\nnegatively\tO\ncorrelated\tO\nwith\tO\nNFkappaB\tO\nactivity\tO\nin\tO\nthe\tO\nfrontal\tO\ncortex\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nlearning\tO\nof\tO\nnew\tO\ntasks\tO\nwas\tO\nenhanced\tO\nand\tO\ncorrelated\tO\nwith\tO\nthe\tO\nincrease\tO\nof\tO\nnNOS\tO\nactivity\tO\nand\tO\nthe\tO\ndecrease\tO\nof\tO\nglutathione\tB-Chemical\nperoxidase\tO\n.\tO\n\nThese\tO\nresults\tO\nprovide\tO\nevidence\tO\nfor\tO\na\tO\npossible\tO\nmechanistic\tO\nrole\tO\nof\tO\noxidative\tO\nand\tO\nnitrosative\tO\nstress\tO\nand\tO\nNFkappaB\tO\nin\tO\nthe\tO\nalterations\tO\ninduced\tO\nby\tO\ncocaine\tB-Chemical\n.\tO\n\nTopiramate\tB-Chemical\nprevented\tO\nall\tO\nthe\tO\nalterations\tO\nobserved\tO\n,\tO\nshowing\tO\nnovel\tO\nneuroprotective\tO\nproperties\tO\n.\tO\n\nEfficacy\tO\nand\tO\nsafety\tO\nof\tO\nasenapine\tB-Chemical\nin\tO\na\tO\nplacebo\tO\n-\tO\nand\tO\nhaloperidol\tB-Chemical\n-\tO\ncontrolled\tO\ntrial\tO\nin\tO\npatients\tO\nwith\tO\nacute\tO\nexacerbation\tO\nof\tO\nschizophrenia\tB-Disease\n.\tO\n\nAsenapine\tB-Chemical\nis\tO\napproved\tO\nby\tO\nthe\tO\nFood\tO\nand\tO\nDrugs\tO\nAdministration\tO\nin\tO\nadults\tO\nfor\tO\nacute\tO\ntreatment\tO\nof\tO\nschizophrenia\tB-Disease\nor\tO\nof\tO\nmanic\tB-Disease\nor\tO\nmixed\tO\nepisodes\tO\nassociated\tO\nwith\tO\nbipolar\tB-Disease\nI\tI-Disease\ndisorder\tI-Disease\nwith\tO\nor\tO\nwithout\tO\npsychotic\tB-Disease\nfeatures\tO\n.\tO\n\nIn\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n6\tO\n-\tO\nweek\tO\ntrial\tO\n,\tO\n458\tO\npatients\tO\nwith\tO\nacute\tO\nschizophrenia\tB-Disease\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nfixed\tO\n-\tO\ndose\tO\ntreatment\tO\nwith\tO\nasenapine\tB-Chemical\nat\tO\n5\tO\nmg\tO\ntwice\tO\ndaily\tO\n(\tO\nBID\tO\n)\tO\n,\tO\nasenapine\tB-Chemical\nat\tO\n10\tO\nmg\tO\nBID\tO\n,\tO\nplacebo\tO\n,\tO\nor\tO\nhaloperidol\tB-Chemical\nat\tO\n4\tO\nmg\tO\nBID\tO\n(\tO\nto\tO\nverify\tO\nassay\tO\nsensitivity\tO\n)\tO\n.\tO\n\nWith\tO\nlast\tO\nobservations\tO\ncarried\tO\nforward\tO\n(\tO\nLOCF\tO\n)\tO\n,\tO\nmean\tO\nPositive\tO\nand\tO\nNegative\tO\nSyndrome\tO\nScale\tO\ntotal\tO\nscore\tO\nreductions\tO\nfrom\tO\nbaseline\tO\nto\tO\nendpoint\tO\nwere\tO\nsignificantly\tO\ngreater\tO\nwith\tO\nasenapine\tB-Chemical\nat\tO\n5\tO\nmg\tO\nBID\tO\n(\tO\n-\tO\n16\tO\n.\tO\n2\tO\n)\tO\nand\tO\nhaloperidol\tB-Chemical\n(\tO\n-\tO\n15\tO\n.\tO\n4\tO\n)\tO\nthan\tO\nplacebo\tO\n(\tO\n-\tO\n10\tO\n.\tO\n7\tO\n;\tO\nboth\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n;\tO\nusing\tO\nmixed\tO\nmodel\tO\nfor\tO\nrepeated\tO\nmeasures\tO\n(\tO\nMMRM\tO\n)\tO\n,\tO\nchanges\tO\nat\tO\nday\tO\n42\tO\nwere\tO\nsignificantly\tO\ngreater\tO\nwith\tO\nasenapine\tB-Chemical\nat\tO\n5\tO\nand\tO\n10\tO\nmg\tO\nBID\tO\n(\tO\n-\tO\n21\tO\n.\tO\n3\tO\nand\tO\n-\tO\n19\tO\n.\tO\n4\tO\n,\tO\nrespectively\tO\n)\tO\nand\tO\nhaloperidol\tB-Chemical\n(\tO\n-\tO\n20\tO\n.\tO\n0\tO\n)\tO\nthan\tO\nplacebo\tO\n(\tO\n-\tO\n14\tO\n.\tO\n6\tO\n;\tO\nall\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nOn\tO\nthe\tO\nPositive\tO\nand\tO\nNegative\tO\nSyndrome\tO\nScale\tO\npositive\tO\nsubscale\tO\n,\tO\nall\tO\ntreatments\tO\nwere\tO\nsuperior\tO\nto\tO\nplacebo\tO\nwith\tO\nLOCF\tO\nand\tO\nMMRM\tO\n;\tO\nasenapine\tB-Chemical\nat\tO\n5\tO\nmg\tO\nBID\tO\nwas\tO\nsuperior\tO\nto\tO\nplacebo\tO\non\tO\nthe\tO\nnegative\tO\nsubscale\tO\nwith\tO\nMMRM\tO\nand\tO\non\tO\nthe\tO\ngeneral\tO\npsychopathology\tO\nsubscale\tO\nwith\tO\nLOCF\tO\nand\tO\nMMRM\tO\n.\tO\n\nTreatment\tO\n-\tO\nrelated\tO\nadverse\tO\nevents\tO\n(\tO\nAEs\tO\n)\tO\noccurred\tO\nin\tO\n44\tO\n%\tO\nand\tO\n52\tO\n%\tO\n,\tO\n57\tO\n%\tO\n,\tO\nand\tO\n41\tO\n%\tO\nof\tO\nthe\tO\nasenapine\tB-Chemical\nat\tO\n5\tO\nand\tO\n10\tO\nmg\tO\nBID\tO\n,\tO\nhaloperidol\tB-Chemical\n,\tO\nand\tO\nplacebo\tO\ngroups\tO\n,\tO\nrespectively\tO\n.\tO\n\nExtrapyramidal\tB-Disease\nsymptoms\tI-Disease\nreported\tO\nas\tO\nAEs\tO\noccurred\tO\nin\tO\n15\tO\n%\tO\nand\tO\n18\tO\n%\tO\n,\tO\n34\tO\n%\tO\n,\tO\nand\tO\n10\tO\n%\tO\nof\tO\nthe\tO\nasenapine\tB-Chemical\nat\tO\n5\tO\nand\tO\n10\tO\nmg\tO\nBID\tO\n,\tO\nhaloperidol\tB-Chemical\n,\tO\nand\tO\nplacebo\tO\ngroups\tO\n,\tO\nrespectively\tO\n.\tO\n\nAcross\tO\nall\tO\ngroups\tO\n,\tO\nno\tO\nmore\tO\nthan\tO\n5\tO\n%\tO\nof\tO\npatients\tO\nhad\tO\nclinically\tO\nsignificant\tO\nweight\tO\nchange\tO\n.\tO\n\nPost\tO\nhoc\tO\nanalyses\tO\nindicated\tO\nthat\tO\nefficacy\tO\nwas\tO\nsimilar\tO\nwith\tO\nasenapine\tB-Chemical\nand\tO\nhaloperidol\tB-Chemical\n;\tO\ngreater\tO\ncontrasts\tO\nwere\tO\nseen\tO\nin\tO\nAEs\tO\n,\tO\nespecially\tO\nextrapyramidal\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nSalvage\tO\ntherapy\tO\nwith\tO\nnelarabine\tB-Chemical\n,\tO\netoposide\tB-Chemical\n,\tO\nand\tO\ncyclophosphamide\tB-Chemical\nin\tO\nrelapsed\tO\n/\tO\nrefractory\tO\npaediatric\tO\nT\tB-Disease\n-\tI-Disease\ncell\tI-Disease\nlymphoblastic\tI-Disease\nleukaemia\tI-Disease\nand\tI-Disease\nlymphoma\tI-Disease\n.\tO\n\nA\tO\ncombination\tO\nof\tO\n5\tO\nd\tO\nof\tO\nnelarabine\tB-Chemical\n(\tO\nAraG\tB-Chemical\n)\tO\nwith\tO\n5\tO\nd\tO\nof\tO\netoposide\tB-Chemical\n(\tO\nVP\tB-Chemical\n)\tO\nand\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCPM\tB-Chemical\n)\tO\nand\tO\nprophylactic\tO\nintrathecal\tO\nchemotherapy\tO\nwas\tO\nused\tO\nas\tO\nsalvage\tO\ntherapy\tO\nin\tO\nseven\tO\nchildren\tO\nwith\tO\nrefractory\tO\nor\tO\nrelapsed\tO\nT\tB-Disease\n-\tI-Disease\ncell\tI-Disease\nleukaemia\tI-Disease\nor\tI-Disease\nlymphoma\tI-Disease\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nside\tO\neffects\tO\nattributable\tO\nto\tO\nthe\tO\nAraG\tB-Chemical\nincluded\tO\nGrade\tO\n2\tO\nand\tO\n3\tO\nsensory\tO\nand\tO\nmotor\tO\nneuropathy\tB-Disease\nand\tO\nmusculoskeletal\tB-Disease\npain\tI-Disease\n.\tO\n\nHaematological\tB-Disease\ntoxicity\tI-Disease\nwas\tO\ngreater\tO\nfor\tO\nthe\tO\ncombination\tO\nthan\tO\nAraG\tB-Chemical\nalone\tO\n,\tO\nalthough\tO\nmedian\tO\ntime\tO\nto\tO\nneutrophil\tO\nand\tO\nplatelet\tO\nrecovery\tO\nwas\tO\nconsistent\tO\nwith\tO\nother\tO\nsalvage\tO\ntherapies\tO\n.\tO\n\nAll\tO\npatients\tO\nhad\tO\nsome\tO\nresponse\tO\nto\tO\nthe\tO\ncombined\tO\ntherapy\tO\nand\tO\nfive\tO\nof\tO\nthe\tO\nseven\tO\nwent\tO\ninto\tO\ncomplete\tO\nremission\tO\nafter\tO\none\tO\nor\tO\ntwo\tO\ncourses\tO\nof\tO\nAraG\tB-Chemical\n/\tO\nVP\tB-Chemical\n/\tO\nCPM\tB-Chemical\n.\tO\n\nOur\tO\nexperience\tO\nsupports\tO\nthe\tO\nsafety\tO\nof\tO\ngiving\tO\nAraG\tB-Chemical\nas\tO\nsalvage\tO\ntherapy\tO\nin\tO\nsynchrony\tO\nwith\tO\netoposide\tB-Chemical\nand\tO\ncyclophosphamide\tB-Chemical\n,\tO\nalthough\tO\nneurological\tB-Disease\ntoxicity\tI-Disease\nmust\tO\nbe\tO\nclosely\tO\nmonitored\tO\n.\tO\n\nEffect\tO\nof\tO\nadriamycin\tB-Chemical\ncombined\tO\nwith\tO\nwhole\tO\nbody\tO\nhyperthermia\tB-Disease\non\tO\ntumor\tB-Disease\nand\tO\nnormal\tO\ntissues\tO\n.\tO\n\nThermal\tO\nenhancement\tO\nof\tO\nAdriamycin\tB-Chemical\n-\tO\nmediated\tO\nantitumor\tO\nactivity\tO\nand\tO\nnormal\tO\ntissue\tO\ntoxicities\tB-Disease\nby\tO\nwhole\tO\nbody\tO\nhyperthermia\tB-Disease\nwere\tO\ncompared\tO\nusing\tO\na\tO\nF344\tO\nrat\tO\nmodel\tO\n.\tO\n\nAntitumor\tO\nactivity\tO\nwas\tO\nstudied\tO\nusing\tO\na\tO\ntumor\tB-Disease\ngrowth\tO\ndelay\tO\nassay\tO\n.\tO\n\nAcute\tO\nnormal\tO\ntissue\tO\ntoxicities\tB-Disease\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nleukopenia\tB-Disease\nand\tO\nthrombocytopenia\tB-Disease\n)\tO\nand\tO\nlate\tO\nnormal\tO\ntissue\tO\ntoxicities\tB-Disease\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nmyocardial\tB-Disease\nand\tI-Disease\nkidney\tI-Disease\ninjury\tI-Disease\n)\tO\nwere\tO\nevaluated\tO\nby\tO\nfunctional\tO\n/\tO\nphysiological\tO\nassays\tO\nand\tO\nby\tO\nmorphological\tO\ntechniques\tO\n.\tO\n\nWhole\tO\nbody\tO\nhyperthermia\tB-Disease\n(\tO\n120\tO\nmin\tO\nat\tO\n41\tO\n.\tO\n5\tO\ndegrees\tO\nC\tO\n)\tO\nenhanced\tO\nboth\tO\nAdriamycin\tB-Chemical\n-\tO\nmediated\tO\nantitumor\tO\nactivity\tO\nand\tO\ntoxic\tO\nside\tO\neffects\tO\n.\tO\n\nThe\tO\nthermal\tO\nenhancement\tO\nratio\tO\ncalculated\tO\nfor\tO\nantitumor\tO\nactivity\tO\nwas\tO\n1\tO\n.\tO\n6\tO\n.\tO\n\nThermal\tO\nenhancement\tO\nratios\tO\nestimated\tO\nfor\tO\n\"\tO\nacute\tO\n\"\tO\nhematological\tO\nchanges\tO\nwere\tO\n1\tO\n.\tO\n3\tO\n,\tO\nwhereas\tO\nthose\tO\nestimated\tO\nfor\tO\n\"\tO\nlate\tO\n\"\tO\ndamage\tO\n(\tO\nbased\tO\non\tO\nmorphological\tO\ncardiac\tB-Disease\nand\tI-Disease\nrenal\tI-Disease\nlesions\tI-Disease\n)\tO\nvaried\tO\nbetween\tO\n2\tO\n.\tO\n4\tO\nand\tO\n4\tO\n.\tO\n3\tO\n.\tO\n\nThus\tO\n,\tO\nwhile\tO\nwhole\tO\nbody\tO\nhyperthermia\tB-Disease\nenhances\tO\nAdriamycin\tB-Chemical\n-\tO\nmediated\tO\nantitumor\tO\neffect\tO\n,\tO\nnormal\tO\ntissue\tO\ntoxicity\tB-Disease\nis\tO\nalso\tO\nincreased\tO\n,\tO\nand\tO\nthe\tO\npotential\tO\ntherapeutic\tO\ngain\tO\nof\tO\nthe\tO\ncombined\tO\nmodality\tO\ntreatment\tO\nis\tO\neroded\tO\n.\tO\n\nPermeability\tO\n,\tO\nultrastructural\tO\nchanges\tO\n,\tO\nand\tO\ndistribution\tO\nof\tO\nnovel\tO\nproteins\tO\nin\tO\nthe\tO\nglomerular\tO\nbarrier\tO\nin\tO\nearly\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nnephrosis\tB-Disease\n.\tO\n\nBACKGROUND\tO\n/\tO\nAIMS\tO\n:\tO\nIt\tO\nis\tO\nstill\tO\nunclear\tO\nwhat\tO\nhappens\tO\nin\tO\nthe\tO\nglomerulus\tO\nwhen\tO\nproteinuria\tB-Disease\nstarts\tO\n.\tO\n\nUsing\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nnephrosis\tB-Disease\n(\tO\nPAN\tO\n)\tO\nrats\tO\n,\tO\nwe\tO\nstudied\tO\nearly\tO\nultrastructural\tO\nand\tO\npermeability\tO\nchanges\tO\nin\tO\nrelation\tO\nto\tO\nthe\tO\nexpression\tO\nof\tO\nthe\tO\npodocyte\tO\n-\tO\nassociated\tO\nmolecules\tO\nnephrin\tO\n,\tO\na\tO\n-\tO\nactinin\tO\n,\tO\ndendrin\tO\n,\tO\nand\tO\nplekhh2\tO\n,\tO\nthe\tO\nlast\tO\ntwo\tO\nof\tO\nwhich\tO\nwere\tO\nonly\tO\nrecently\tO\ndiscovered\tO\nin\tO\npodocytes\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nimmune\tO\nstainings\tO\n,\tO\nsemiquantitative\tO\nmeasurement\tO\nwas\tO\nperformed\tO\nunder\tO\nthe\tO\nelectron\tO\nmicroscope\tO\n.\tO\n\nPermeability\tO\nwas\tO\nassessed\tO\nusing\tO\nisolated\tO\nkidney\tO\nperfusion\tO\nwith\tO\ntracers\tO\n.\tO\n\nPossible\tO\neffects\tO\nof\tO\nACE\tO\ninhibition\tO\nwere\tO\ntested\tO\n.\tO\n\nRESULTS\tO\n:\tO\nBy\tO\nday\tO\n2\tO\n,\tO\nsome\tO\npatchy\tO\nfoot\tO\nprocess\tO\neffacement\tO\n,\tO\nbut\tO\nno\tO\nproteinuria\tB-Disease\n,\tO\nappeared\tO\n.\tO\n\nThe\tO\namount\tO\nof\tO\nnephrin\tO\nwas\tO\nreduced\tO\nin\tO\nboth\tO\ndiseased\tO\nand\tO\nnormal\tO\nareas\tO\n.\tO\n\nThe\tO\nother\tO\nproteins\tO\nshowed\tO\nfew\tO\nchanges\tO\n,\tO\nwhich\tO\nwere\tO\nlimited\tO\nto\tO\ndiseased\tO\nareas\tO\n.\tO\n\nBy\tO\nday\tO\n4\tO\n,\tO\nfoot\tO\nprocess\tO\neffacement\tO\nwas\tO\ncomplete\tO\nand\tO\nproteinuria\tB-Disease\nappeared\tO\nin\tO\nparallel\tO\nwith\tO\nsigns\tO\nof\tO\nsize\tO\nbarrier\tO\ndamage\tO\n.\tO\n\nNephrin\tO\ndecreased\tO\nfurther\tO\n,\tO\nwhile\tO\ndendrin\tO\nand\tO\nplekhh2\tO\nalso\tO\ndecreased\tO\nbut\tO\na\tO\n-\tO\nactinin\tO\nremained\tO\nunchanged\tO\n.\tO\n\nACE\tO\ninhibition\tO\nhad\tO\nno\tO\nsignificant\tO\nprotective\tO\neffect\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPAN\tO\nglomeruli\tO\nalready\tO\nshowed\tO\nsignificant\tO\npathology\tO\nby\tO\nday\tO\n4\tO\n,\tO\ndespite\tO\nrelatively\tO\nmild\tO\nproteinuria\tB-Disease\n.\tO\n\nThis\tO\nwas\tO\npreceded\tO\nby\tO\naltered\tO\nnephrin\tO\nexpression\tO\n,\tO\nsupporting\tO\nits\tO\npivotal\tO\nrole\tO\nin\tO\npodocyte\tO\nmorphology\tO\n.\tO\n\nThe\tO\nnovel\tO\nproteins\tO\ndendrin\tO\nand\tO\nplekhh2\tO\nwere\tO\nboth\tO\nreduced\tO\n,\tO\nsuggesting\tO\nroles\tO\nin\tO\nPAN\tO\n,\tO\nwhereas\tO\na\tO\n-\tO\nactinin\tO\nwas\tO\nunchanged\tO\n.\tO\n\nA\tO\nnovel\tO\n,\tO\nmultiple\tO\nsymptom\tO\nmodel\tO\nof\tO\nobsessive\tB-Disease\n-\tI-Disease\ncompulsive\tI-Disease\n-\tI-Disease\nlike\tI-Disease\nbehaviors\tI-Disease\nin\tO\nanimals\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCurrent\tO\nanimal\tO\nmodels\tO\nof\tO\nobsessive\tB-Disease\n-\tI-Disease\ncompulsive\tI-Disease\ndisorder\tI-Disease\n(\tO\nOCD\tB-Disease\n)\tO\ntypically\tO\ninvolve\tO\nacute\tO\n,\tO\ndrug\tO\n-\tO\ninduced\tO\nsymptom\tO\nprovocation\tO\nor\tO\na\tO\ngenetic\tO\nassociation\tO\nwith\tO\nstereotypies\tO\nor\tO\nanxiety\tB-Disease\n.\tO\n\nNone\tO\nof\tO\nthese\tO\ncurrent\tO\nmodels\tO\ndemonstrate\tO\nmultiple\tO\nOCD\tB-Disease\n-\tO\nlike\tO\nbehaviors\tO\n.\tO\n\nMETHODS\tO\n:\tO\nNeonatal\tO\nrats\tO\nwere\tO\ntreated\tO\nwith\tO\nthe\tO\ntricyclic\tO\nantidepressant\tB-Chemical\nclomipramine\tB-Chemical\nor\tO\nvehicle\tO\nbetween\tO\ndays\tO\n9\tO\nand\tO\n16\tO\ntwice\tO\ndaily\tO\nand\tO\nbehaviorally\tO\ntested\tO\nin\tO\nadulthood\tO\n.\tO\n\nRESULTS\tO\n:\tO\nClomipramine\tB-Chemical\nexposure\tO\nin\tO\nimmature\tO\nrats\tO\nproduced\tO\nsignificant\tO\nbehavioral\tO\nand\tO\nbiochemical\tO\nchanges\tO\nthat\tO\ninclude\tO\nenhanced\tO\nanxiety\tB-Disease\n(\tO\nelevated\tO\nplus\tO\nmaze\tO\nand\tO\nmarble\tO\nburying\tO\n)\tO\n,\tO\nbehavioral\tB-Disease\ninflexibility\tI-Disease\n(\tO\nperseveration\tO\nin\tO\nthe\tO\nspontaneous\tO\nalternation\tO\ntask\tO\nand\tO\nimpaired\tO\nreversal\tO\nlearning\tO\n)\tO\n,\tO\nworking\tO\nmemory\tB-Disease\nimpairment\tI-Disease\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nwin\tO\n-\tO\nshift\tO\nparadigm\tO\n)\tO\n,\tO\nhoarding\tB-Disease\n,\tO\nand\tO\ncorticostriatal\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nDopamine\tB-Chemical\nD2\tO\nreceptors\tO\nwere\tO\nelevated\tO\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nwhereas\tO\nserotonin\tB-Chemical\n2C\tO\n,\tO\nbut\tO\nnot\tO\nserotonin\tB-Chemical\n1A\tO\n,\tO\nreceptors\tO\nwere\tO\nelevated\tO\nin\tO\nthe\tO\norbital\tO\nfrontal\tO\ncortex\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThis\tO\nis\tO\nthe\tO\nfirst\tO\ndemonstration\tO\nof\tO\nmultiple\tO\nsymptoms\tO\nconsistent\tO\nwith\tO\nan\tO\nOCD\tB-Disease\n-\tO\nlike\tO\nprofile\tO\nin\tO\nanimals\tO\n.\tO\n\nMoreover\tO\n,\tO\nthese\tO\nbehaviors\tO\nare\tO\naccompanied\tO\nby\tO\nbiochemical\tO\nchanges\tO\nin\tO\nbrain\tO\nregions\tO\npreviously\tO\nidentified\tO\nas\tO\nrelevant\tO\nto\tO\nOCD\tB-Disease\n.\tO\n\nThis\tO\nnovel\tO\nmodel\tO\nof\tO\nOCD\tB-Disease\ndemonstrates\tO\nthat\tO\ndrug\tO\nexposure\tO\nduring\tO\na\tO\nsensitive\tO\nperiod\tO\ncan\tO\nprogram\tO\ndisease\tO\n-\tO\nlike\tO\nsystems\tO\npermanently\tO\n,\tO\nwhich\tO\ncould\tO\nhave\tO\nimplications\tO\nfor\tO\ncurrent\tO\nand\tO\nfuture\tO\ntherapeutic\tO\nstrategies\tO\nfor\tO\nthis\tO\nand\tO\nother\tO\npsychiatric\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nElevation\tO\nof\tO\nADAM10\tO\n,\tO\nADAM17\tO\n,\tO\nMMP\tO\n-\tO\n2\tO\nand\tO\nMMP\tO\n-\tO\n9\tO\nexpression\tO\nwith\tO\nmedia\tO\ndegeneration\tO\nfeatures\tO\nCaCl2\tB-Chemical\n-\tO\ninduced\tO\nthoracic\tB-Disease\naortic\tI-Disease\naneurysm\tI-Disease\nin\tO\na\tO\nrat\tO\nmodel\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nThis\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nestablish\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nthoracic\tB-Disease\naortic\tI-Disease\naneurysm\tI-Disease\n(\tO\nTAA\tB-Disease\n)\tO\nby\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\n(\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\n)\tO\n-\tO\ninduced\tO\narterial\tB-Disease\ninjury\tI-Disease\nand\tO\nto\tO\nexplore\tO\nthe\tO\npotential\tO\nrole\tO\nof\tO\na\tO\ndisintegrin\tO\nand\tO\nmetalloproteinase\tO\n(\tO\nADAM\tO\n)\tO\n,\tO\nmatrix\tO\nmetalloproteinases\tO\n(\tO\nMMPs\tO\n)\tO\nand\tO\ntheir\tO\nendogenous\tO\ninhibitors\tO\n(\tO\nTIMPs\tO\n)\tO\nin\tO\nTAA\tB-Disease\nformation\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThoracic\tO\naorta\tO\nof\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwas\tO\nexposed\tO\nto\tO\n0\tO\n.\tO\n5M\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\nor\tO\nnormal\tO\nsaline\tO\n(\tO\nNaCl\tB-Chemical\n)\tO\n.\tO\n\nAfter\tO\n12weeks\tO\n,\tO\nanimals\tO\nwere\tO\neuthanized\tO\n,\tO\nand\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\n-\tO\ntreated\tO\n,\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\n-\tO\nuntreated\tO\n(\tO\nn\tO\n=\tO\n12\tO\n)\tO\nand\tO\nNaCl\tB-Chemical\n-\tO\ntreated\tO\naortic\tO\nsegments\tO\n(\tO\nn\tO\n=\tO\n12\tO\n)\tO\nwere\tO\ncollected\tO\nfor\tO\nhistological\tO\nand\tO\nmolecular\tO\nassessments\tO\n.\tO\n\nMMP\tO\n-\tO\nTIMP\tO\nand\tO\nADAM\tO\nmRNAs\tO\nwere\tO\nsemi\tO\n-\tO\nquantitatively\tO\nanalyzed\tO\nand\tO\nprotein\tO\nexpressions\tO\nwere\tO\ndetermined\tO\nby\tO\nimmunohistochemistry\tO\n.\tO\n\nRESULTS\tO\n:\tO\nDespite\tO\nsimilar\tO\nexternal\tO\ndiameters\tO\namong\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\n-\tO\ntreated\tO\n,\tO\nnon\tO\n-\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\n-\tO\ntreated\tO\nand\tO\nNaCl\tB-Chemical\n-\tO\ntreated\tO\nsegments\tO\n,\tO\naneurymal\tO\nalteration\tO\n(\tO\nn\tO\n=\tO\n6\tO\n,\tO\n50\tO\n%\tO\n)\tO\n,\tO\nmedia\tO\ndegeneration\tO\nwith\tO\nregional\tO\ndisruption\tO\n,\tO\nfragmentation\tO\nof\tO\nelastic\tO\nfiber\tO\n,\tO\nand\tO\nincreased\tO\ncollagen\tO\ndeposition\tO\n(\tO\nn\tO\n=\tO\n12\tO\n,\tO\n100\tO\n%\tO\n)\tO\nwere\tO\ndemonstrated\tO\nin\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\n-\tO\ntreated\tO\nsegments\tO\n.\tO\n\nMMP\tO\n-\tO\n2\tO\n,\tO\nMMP\tO\n-\tO\n9\tO\n,\tO\nADAM\tO\n-\tO\n10\tO\nand\tO\nADAM\tO\n-\tO\n17\tO\nmRNA\tO\nlevels\tO\nwere\tO\nincreased\tO\nin\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\n-\tO\ntreated\tO\nsegments\tO\n(\tO\nall\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nwith\tO\ntrends\tO\nof\tO\nelevation\tO\nin\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\n-\tO\nuntreated\tO\nsegments\tO\n,\tO\nas\tO\ncompared\tO\nwith\tO\nNaCl\tB-Chemical\n-\tO\ntreated\tO\nsegments\tO\n.\tO\n\nImmunohistochemistry\tO\ndisplayed\tO\nsignificantly\tO\nincreased\tO\nexpressions\tO\nof\tO\nMMP\tO\n-\tO\n2\tO\n,\tO\nMMP\tO\n-\tO\n9\tO\n,\tO\nADAM\tO\n-\tO\n10\tO\nand\tO\nADAM\tO\n-\tO\n17\tO\n(\tO\nall\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\nin\tO\nintima\tO\nand\tO\nmedia\tO\nfor\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\n-\tO\ntreated\tO\nsegments\tO\n.\tO\n\nTIMP\tO\nmRNA\tO\nand\tO\ntissue\tO\nlevels\tO\ndid\tO\nnot\tO\ndiffer\tO\nobviously\tO\namong\tO\nthe\tO\nthree\tO\naortic\tO\nsegments\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nstudy\tO\nestablishes\tO\na\tO\nTAA\tB-Disease\nmodel\tO\nby\tO\nperiarterial\tO\nCaCl\tB-Chemical\n(\tI-Chemical\n2\tI-Chemical\n)\tI-Chemical\nexposure\tO\nin\tO\nrats\tO\n,\tO\nand\tO\ndemonstrates\tO\na\tO\nsignificant\tO\nelevation\tO\nof\tO\nexpression\tO\nof\tO\nMMP\tO\n-\tO\n2\tO\n,\tO\nMMP\tO\n-\tO\n9\tO\n,\tO\nADAM10\tO\nand\tO\nADAM17\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nvascular\tO\nremodeling\tO\n.\tO\n\nSuxamethonium\tB-Chemical\ninduced\tO\nprolonged\tO\napnea\tB-Disease\nin\tO\na\tO\npatient\tO\nreceiving\tO\nelectroconvulsive\tO\ntherapy\tO\n.\tO\n\nSuxamethonium\tB-Chemical\ncauses\tO\nprolonged\tO\napnea\tB-Disease\nin\tO\npatients\tO\nin\tO\nwhom\tO\npseudocholinesterase\tO\nenzyme\tO\ngets\tO\ndeactivated\tO\nby\tO\norganophosphorus\tB-Chemical\n(\tI-Chemical\nOP\tI-Chemical\n)\tI-Chemical\npoisons\tI-Chemical\n.\tO\n\nHere\tO\n,\tO\nwe\tO\npresent\tO\na\tO\nsimilar\tO\nincident\tO\nin\tO\na\tO\nseverely\tO\ndepressed\tB-Disease\npatient\tO\nwho\tO\nreceived\tO\nelectroconvulsive\tO\ntherapy\tO\n(\tO\nECT\tO\n)\tO\n.\tO\n\nProlonged\tO\napnea\tB-Disease\nin\tO\nour\tO\ncase\tO\nensued\tO\nbecause\tO\nthe\tO\ninformation\tO\nabout\tO\nsuicidal\tO\nattempt\tO\nby\tO\nOP\tB-Chemical\ncompound\tI-Chemical\nwas\tO\nconcealed\tO\nfrom\tO\nthe\tO\ntreating\tO\nteam\tO\n.\tO\n\nCurcumin\tB-Chemical\nameliorates\tO\ncognitive\tB-Disease\ndysfunction\tI-Disease\nand\tO\noxidative\tO\ndamage\tO\nin\tO\nphenobarbitone\tB-Chemical\nand\tO\ncarbamazepine\tB-Chemical\nadministered\tO\nrats\tO\n.\tO\n\nThe\tO\nantiepileptic\tO\ndrugs\tO\n,\tO\nphenobarbitone\tB-Chemical\nand\tO\ncarbamazepine\tB-Chemical\nare\tO\nwell\tO\nknown\tO\nto\tO\ncause\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\non\tO\nchronic\tO\nuse\tO\n.\tO\n\nThe\tO\nincrease\tO\nin\tO\nfree\tO\nradical\tO\ngeneration\tO\nhas\tO\nbeen\tO\nimplicated\tO\nas\tO\none\tO\nof\tO\nthe\tO\nimportant\tO\nmechanisms\tO\nof\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\nby\tO\nantiepileptic\tO\ndrugs\tO\n.\tO\n\nCurcumin\tB-Chemical\nhas\tO\nshown\tO\nantioxidant\tO\n,\tO\nanti\tO\n-\tO\ninflammatory\tO\nand\tO\nneuro\tO\n-\tO\nprotective\tO\nproperties\tO\n.\tO\n\nTherefore\tO\n,\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\ncarried\tO\nout\tO\nto\tO\ninvestigate\tO\nthe\tO\neffect\tO\nof\tO\nchronic\tO\ncurcumin\tB-Chemical\nadministration\tO\non\tO\nphenobarbitone\tB-Chemical\n-\tO\nand\tO\ncarbamazepine\tB-Chemical\n-\tO\ninduced\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\nand\tO\noxidative\tO\nstress\tO\nin\tO\nrats\tO\n.\tO\n\nPharmacokinetic\tO\ninteractions\tO\nof\tO\ncurcumin\tB-Chemical\nwith\tO\nphenobarbitone\tB-Chemical\nand\tO\ncarbamazepine\tB-Chemical\nwere\tO\nalso\tO\nstudied\tO\n.\tO\n\nVehicle\tO\n/\tO\ndrugs\tO\nwere\tO\nadministered\tO\ndaily\tO\nfor\tO\n21days\tO\nto\tO\nmale\tO\nWistar\tO\nrats\tO\n.\tO\n\nPassive\tO\navoidance\tO\nparadigm\tO\nand\tO\nelevated\tO\nplus\tO\nmaze\tO\ntest\tO\nwere\tO\nused\tO\nto\tO\nassess\tO\ncognitive\tO\nfunction\tO\n.\tO\n\nAt\tO\nthe\tO\nend\tO\nof\tO\nstudy\tO\nperiod\tO\n,\tO\nserum\tO\nphenobarbitone\tB-Chemical\nand\tO\ncarbamazepine\tB-Chemical\n,\tO\nwhole\tO\nbrain\tO\nmalondialdehyde\tB-Chemical\nand\tO\nreduced\tO\nglutathione\tB-Chemical\nlevels\tO\nwere\tO\nestimated\tO\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nphenobarbitone\tB-Chemical\nand\tO\ncarbamazepine\tB-Chemical\nfor\tO\n21days\tO\ncaused\tO\na\tO\nsignificant\tO\nimpairment\tB-Disease\nof\tI-Disease\nlearning\tI-Disease\nand\tI-Disease\nmemory\tI-Disease\nas\tO\nwell\tO\nas\tO\nan\tO\nincreased\tO\noxidative\tO\nstress\tO\n.\tO\n\nConcomitant\tO\ncurcumin\tB-Chemical\nadministration\tO\nprevented\tO\nthe\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\nand\tO\ndecreased\tO\nthe\tO\nincreased\tO\noxidative\tO\nstress\tO\ninduced\tO\nby\tO\nthese\tO\nantiepileptic\tO\ndrugs\tO\n.\tO\n\nCurcumin\tB-Chemical\nco\tO\n-\tO\nadministration\tO\ndid\tO\nnot\tO\ncause\tO\nany\tO\nsignificant\tO\nalteration\tO\nin\tO\nthe\tO\nserum\tO\nconcentrations\tO\nof\tO\nboth\tO\nphenobarbitone\tB-Chemical\nas\tO\nwell\tO\nas\tO\ncarbamazepine\tB-Chemical\n.\tO\n\nThese\tO\nresults\tO\nshow\tO\nthat\tO\ncurcumin\tB-Chemical\nhas\tO\nbeneficial\tO\neffect\tO\nin\tO\nmitigating\tO\nthe\tO\ndeterioration\tB-Disease\nof\tI-Disease\ncognitive\tI-Disease\nfunctions\tI-Disease\nand\tO\noxidative\tO\ndamage\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\nphenobarbitone\tB-Chemical\nand\tO\ncarbamazepine\tB-Chemical\nwithout\tO\nsignificantly\tO\naltering\tO\ntheir\tO\nserum\tO\nconcentrations\tO\n.\tO\n\nThe\tO\nfindings\tO\nsuggest\tO\nthat\tO\ncurcumin\tB-Chemical\ncan\tO\nbe\tO\nconsidered\tO\nas\tO\na\tO\npotential\tO\nsafe\tO\nand\tO\neffective\tO\nadjuvant\tO\nto\tO\nphenobarbitone\tB-Chemical\nand\tO\ncarbamazepine\tB-Chemical\ntherapy\tO\nin\tO\npreventing\tO\ncognitive\tB-Disease\nimpairment\tI-Disease\nassociated\tO\nwith\tO\nthese\tO\ndrugs\tO\n.\tO\n\nCan\tO\nangiogenesis\tO\nbe\tO\na\tO\ntarget\tO\nof\tO\ntreatment\tO\nfor\tO\nribavirin\tB-Chemical\nassociated\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n?\tO\n\nBACKGROUND\tO\n/\tO\nAIMS\tO\n:\tO\nRecently\tO\nribavirin\tB-Chemical\nhas\tO\nbeen\tO\nfound\tO\nto\tO\ninhibit\tO\nangiogenesis\tO\nand\tO\na\tO\nnumber\tO\nof\tO\nangiogenesis\tO\ninhibitors\tO\nsuch\tO\nas\tO\nsunitinib\tB-Chemical\nand\tO\nsorafenib\tB-Chemical\nhave\tO\nbeen\tO\nfound\tO\nto\tO\ncause\tO\nacute\tO\nhemolysis\tB-Disease\n.\tO\n\nWe\tO\naimed\tO\nto\tO\ninvestigate\tO\nwhether\tO\nthere\tO\nis\tO\na\tO\nrelation\tO\nbetween\tO\nhemoglobin\tO\n,\tO\nhaptoglobin\tO\nand\tO\nangiogenesis\tO\nsoluble\tO\nmarkers\tO\nwhich\tO\nare\tO\nmodifiable\tO\nand\tO\ncan\tO\nhelp\tO\nin\tO\ndeveloping\tO\nstrategies\tO\nagainst\tO\nanemia\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nFourteen\tO\npatients\tO\nchronically\tB-Disease\ninfected\tI-Disease\nwith\tI-Disease\nhepatitis\tI-Disease\nC\tI-Disease\nvirus\tI-Disease\nwere\tO\ntreated\tO\nby\tO\npegylated\tB-Chemical\ninterferon\tI-Chemical\nalpha\tI-Chemical\n2a\tI-Chemical\nand\tO\nribavirin\tB-Chemical\n.\tO\n\nSerum\tO\nhemoglobin\tO\n,\tO\nhaptoglobin\tO\nand\tO\nangiogenesis\tO\nmarkers\tO\nof\tO\nvascular\tO\nendothelial\tO\ngrowth\tO\nfactor\tO\nand\tO\nangiopoetin\tO\n-\tO\n2\tO\nwere\tO\ninvestigated\tO\nbefore\tO\nand\tO\nafter\tO\ntherapy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nobserved\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nhaptoglobin\tO\nlevels\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\ntreatment\tO\nperiod\tO\n.\tO\n\nHemoglobin\tO\nlevels\tO\nalso\tO\ndecreased\tO\nbut\tO\ninsignificantly\tO\nby\tO\ntreatment\tO\n.\tO\n\nIn\tO\ncontrast\tO\nwith\tO\nthe\tO\nliterature\tO\n,\tO\nserum\tO\nlevels\tO\nof\tO\nangiogenesis\tO\nfactors\tO\ndid\tO\nnot\tO\nchange\tO\nsignificantly\tO\nby\tO\npegylated\tB-Chemical\ninterferon\tI-Chemical\nand\tO\nribavirin\tB-Chemical\ntherapy\tO\n.\tO\n\nWe\tO\nfound\tO\nno\tO\ncorrelation\tO\nof\tO\nangiogenesis\tO\nsoluble\tO\nmarkers\tO\nwith\tO\neither\tO\nhemoglobin\tO\nor\tO\nhaptoglobin\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nstudy\tO\nin\tO\nthe\tO\nliterature\tO\ninvestigating\tO\na\tO\nlink\tO\nbetween\tO\nangiogenesis\tO\nsoluble\tO\nmarkers\tO\nand\tO\nribavirin\tB-Chemical\ninduced\tO\nanemia\tB-Disease\nin\tO\npatients\tO\nwith\tO\nhepatitis\tB-Disease\nC\tI-Disease\nand\tO\nwe\tO\ncould\tO\nnot\tO\nfind\tO\nany\tO\nrelation\tO\n.\tO\n\nFuture\tO\nresearch\tO\nwith\tO\nlarger\tO\nnumber\tO\nof\tO\npatients\tO\nis\tO\nneeded\tO\nto\tO\nfind\tO\nout\tO\nmodifiable\tO\nfactors\tO\nthat\tO\nwill\tO\nimprove\tO\nthe\tO\nsafety\tO\nof\tO\nribavirin\tB-Chemical\ntherapy\tO\n.\tO\n\nReduction\tO\nin\tO\ninjection\tO\npain\tB-Disease\nusing\tO\nbuffered\tO\nlidocaine\tB-Chemical\nas\tO\na\tO\nlocal\tO\nanesthetic\tO\nbefore\tO\ncardiac\tO\ncatheterization\tO\n.\tO\n\nPrevious\tO\nreports\tO\nhave\tO\nsuggested\tO\nthat\tO\npain\tB-Disease\nassociated\tO\nwith\tO\nthe\tO\ninjection\tO\nof\tO\nlidocaine\tB-Chemical\nis\tO\nrelated\tO\nto\tO\nthe\tO\nacidic\tO\npH\tO\nof\tO\nthe\tO\nsolution\tO\n.\tO\n\nTo\tO\ndetermine\tO\nif\tO\nthe\tO\naddition\tO\nof\tO\na\tO\nbuffering\tO\nsolution\tO\nto\tO\nadjust\tO\nthe\tO\npH\tO\nof\tO\nlidocaine\tB-Chemical\ninto\tO\nthe\tO\nphysiologic\tO\nrange\tO\nwould\tO\nreduce\tO\npain\tB-Disease\nduring\tO\ninjection\tO\n,\tO\nwe\tO\nperformed\tO\na\tO\nblinded\tO\nrandomized\tO\nstudy\tO\nin\tO\npatients\tO\nundergoing\tO\ncardiac\tO\ncatheterization\tO\n.\tO\n\nTwenty\tO\npatients\tO\nwere\tO\nasked\tO\nto\tO\nquantify\tO\nthe\tO\nseverity\tO\nof\tO\npain\tB-Disease\nafter\tO\nreceiving\tO\nstandard\tO\nlidocaine\tB-Chemical\nin\tO\none\tO\nfemoral\tO\narea\tO\nand\tO\nbuffered\tO\nlidocaine\tB-Chemical\nin\tO\nthe\tO\nopposite\tO\nfemoral\tO\narea\tO\n.\tO\n\nThe\tO\nmean\tO\npain\tB-Disease\nscore\tO\nfor\tO\nbuffered\tO\nlidocaine\tB-Chemical\nwas\tO\nsignificantly\tO\nlower\tO\nthan\tO\nthe\tO\nmean\tO\nscore\tO\nfor\tO\nstandard\tO\nlidocaine\tB-Chemical\n(\tO\n2\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n9\tO\nvs\tO\n.\tO\n3\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n2\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n03\tO\n)\tO\n.\tO\n\nThe\tO\npH\tO\nadjustment\tO\nof\tO\nstandard\tO\nlidocaine\tB-Chemical\ncan\tO\nbe\tO\naccomplished\tO\neasily\tO\nin\tO\nthe\tO\ncatheterization\tO\nlaboratory\tO\nbefore\tO\ninjection\tO\nand\tO\nresults\tO\nin\tO\na\tO\nreduction\tO\nof\tO\nthe\tO\npain\tB-Disease\noccurring\tO\nduring\tO\nthe\tO\ninfiltration\tO\nof\tO\ntissues\tO\n.\tO\n\nEffect\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\nglyceryl\tI-Chemical\n-\tI-Chemical\nphosphorylcholine\tI-Chemical\non\tO\namnesia\tB-Disease\ncaused\tO\nby\tO\nscopolamine\tB-Chemical\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ncarried\tO\nout\tO\nto\tO\ntest\tO\nthe\tO\neffects\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\nglycerylphosphorylcholine\tI-Chemical\n(\tO\nL\tB-Chemical\n-\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\nGFC\tI-Chemical\n)\tO\non\tO\nmemory\tB-Disease\nimpairment\tI-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\nin\tO\nman\tO\n.\tO\n\nThirty\tO\n-\tO\ntwo\tO\nhealthy\tO\nyoung\tO\nvolunteers\tO\nwere\tO\nrandomly\tO\nallocated\tO\nto\tO\nfour\tO\ndifferent\tO\ngroups\tO\n.\tO\n\nThey\tO\nwere\tO\ngiven\tO\na\tO\nten\tO\nday\tO\npretreatment\tO\nwith\tO\neither\tO\nL\tB-Chemical\n-\tI-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\nGFC\tI-Chemical\nor\tO\nplacebo\tO\n,\tO\np\tO\n.\tO\no\tO\n.\tO\n,\tO\nand\tO\non\tO\nthe\tO\neleventh\tO\nday\tO\neither\tO\nscopolamine\tB-Chemical\nor\tO\nplacebo\tO\n,\tO\ni\tO\n.\tO\nm\tO\n.\tO\n\nBefore\tO\nand\tO\n0\tO\n.\tO\n5\tO\n,\tO\n1\tO\n,\tO\n2\tO\n,\tO\n3\tO\n,\tO\nand\tO\n6\tO\nh\tO\nafter\tO\ninjection\tO\nthe\tO\nsubjects\tO\nwere\tO\ngiven\tO\nattention\tO\nand\tO\nmnemonic\tO\ntests\tO\n.\tO\n\nThe\tO\nfindings\tO\nof\tO\nthis\tO\nstudy\tO\nindicate\tO\nthat\tO\nthe\tO\ndrug\tO\nis\tO\nable\tO\nto\tO\nantagonize\tO\nimpairment\tB-Disease\nof\tI-Disease\nattention\tI-Disease\nand\tI-Disease\nmemory\tI-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\n.\tO\n\nSafety\tO\nof\tO\ncapecitabine\tB-Chemical\n:\tO\na\tO\nreview\tO\n.\tO\n\nIMPORTANCE\tO\nOF\tO\nTHE\tO\nFIELD\tO\n:\tO\nFluoropyrimidines\tB-Chemical\n,\tO\nin\tO\nparticular\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\n,\tO\nhave\tO\nbeen\tO\nthe\tO\nmainstay\tO\nof\tO\ntreatment\tO\nfor\tO\nseveral\tO\nsolid\tO\ntumors\tB-Disease\n,\tO\nincluding\tO\ncolorectal\tB-Disease\n,\tI-Disease\nbreast\tI-Disease\nand\tI-Disease\nhead\tI-Disease\nand\tI-Disease\nneck\tI-Disease\ncancers\tI-Disease\n,\tO\nfor\tO\n>\tO\n40\tO\nyears\tO\n.\tO\n\nAREAS\tO\nCOVERED\tO\nIN\tO\nTHIS\tO\nREVIEW\tO\n:\tO\nThis\tO\narticle\tO\nreviews\tO\nthe\tO\npharmacology\tO\nand\tO\nefficacy\tO\nof\tO\ncapecitabine\tB-Chemical\nwith\tO\na\tO\nspecial\tO\nemphasis\tO\non\tO\nits\tO\nsafety\tO\n.\tO\n\nWHAT\tO\nTHE\tO\nREADER\tO\nWILL\tO\nGAIN\tO\n:\tO\nThe\tO\nreader\tO\nwill\tO\ngain\tO\nbetter\tO\ninsight\tO\ninto\tO\nthe\tO\nsafety\tO\nof\tO\ncapecitabine\tB-Chemical\nin\tO\nspecial\tO\npopulations\tO\nsuch\tO\nas\tO\npatients\tO\nwith\tO\nadvanced\tO\nage\tO\n,\tO\nrenal\tB-Disease\nand\tI-Disease\nkidney\tI-Disease\ndisease\tI-Disease\n.\tO\n\nWe\tO\nalso\tO\nexplore\tO\ndifferent\tO\ndosing\tO\nand\tO\nschedules\tO\nof\tO\ncapecitabine\tB-Chemical\nadministration\tO\n.\tO\n\nTAKE\tO\nHOME\tO\nMESSAGE\tO\n:\tO\nCapecitabine\tB-Chemical\nis\tO\nan\tO\noral\tO\nprodrug\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nand\tO\nwas\tO\ndeveloped\tO\nto\tO\nfulfill\tO\nthe\tO\nneed\tO\nfor\tO\na\tO\nmore\tO\nconvenient\tO\ntherapy\tO\nand\tO\nprovide\tO\nan\tO\nimproved\tO\nsafety\tO\n/\tO\nefficacy\tO\nprofile\tO\n.\tO\n\nIt\tO\nhas\tO\nshown\tO\npromising\tO\nresults\tO\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nother\tO\nchemotherapeutic\tO\nagents\tO\nin\tO\ncolorectal\tB-Disease\n,\tI-Disease\nbreast\tI-Disease\n,\tI-Disease\npancreaticobiliary\tI-Disease\n,\tI-Disease\ngastric\tI-Disease\n,\tI-Disease\nrenal\tI-Disease\ncell\tI-Disease\nand\tI-Disease\nhead\tI-Disease\nand\tI-Disease\nneck\tI-Disease\ncancers\tI-Disease\n.\tO\n\nThe\tO\nmost\tO\ncommonly\tO\nreported\tO\ntoxic\tO\neffects\tO\nof\tO\ncapecitabine\tB-Chemical\nare\tO\ndiarrhea\tB-Disease\n,\tO\nnausea\tB-Disease\n,\tO\nvomiting\tB-Disease\n,\tO\nstomatitis\tB-Disease\nand\tO\nhand\tB-Disease\n-\tI-Disease\nfoot\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nCapecitabine\tB-Chemical\nhas\tO\na\tO\nwell\tO\n-\tO\nestablished\tO\nsafety\tO\nprofile\tO\nand\tO\ncan\tO\nbe\tO\ngiven\tO\nsafely\tO\nto\tO\npatients\tO\nwith\tO\nadvanced\tO\nage\tO\n,\tO\nhepatic\tB-Disease\nand\tI-Disease\nrenal\tI-Disease\ndysfunctions\tI-Disease\n.\tO\n\nLevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\nin\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n:\tO\nfilling\tO\nthe\tO\nbench\tO\n-\tO\nto\tO\n-\tO\nbedside\tO\ngap\tO\n.\tO\n\nLevodopa\tB-Chemical\nis\tO\nthe\tO\nmost\tO\neffective\tO\ndrug\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nthis\tO\ndopamine\tB-Chemical\nprecursor\tO\nis\tO\ncomplicated\tO\nby\tO\nhighly\tO\ndisabling\tO\nfluctuations\tO\nand\tO\ndyskinesias\tB-Disease\n.\tO\n\nAlthough\tO\npreclinical\tO\nand\tO\nclinical\tO\nfindings\tO\nsuggest\tO\npulsatile\tO\nstimulation\tO\nof\tO\nstriatal\tO\npostsynaptic\tO\nreceptors\tO\nas\tO\na\tO\nkey\tO\nmechanism\tO\nunderlying\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n,\tO\ntheir\tO\npathogenesis\tO\nis\tO\nstill\tO\nunclear\tO\n.\tO\n\nIn\tO\nrecent\tO\nyears\tO\n,\tO\nevidence\tO\nfrom\tO\nanimal\tO\nmodels\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nhas\tO\nprovided\tO\nimportant\tO\ninformation\tO\nto\tO\nunderstand\tO\nthe\tO\neffect\tO\nof\tO\nspecific\tO\nreceptor\tO\nand\tO\npost\tO\n-\tO\nreceptor\tO\nmolecular\tO\nmechanisms\tO\nunderlying\tO\nthe\tO\ndevelopment\tO\nof\tO\ndyskinetic\tB-Disease\nmovements\tI-Disease\n.\tO\n\nRecent\tO\npreclinical\tO\nand\tO\nclinical\tO\ndata\tO\nfrom\tO\npromising\tO\nlines\tO\nof\tO\nresearch\tO\nfocus\tO\non\tO\nthe\tO\ndifferential\tO\nrole\tO\nof\tO\npresynaptic\tO\nversus\tO\npostsynaptic\tO\nmechanisms\tO\n,\tO\ndopamine\tB-Chemical\nreceptor\tO\nsubtypes\tO\n,\tO\nionotropic\tO\nand\tO\nmetabotropic\tO\nglutamate\tB-Chemical\nreceptors\tO\n,\tO\nand\tO\nnon\tO\n-\tO\ndopaminergic\tO\nneurotransmitter\tO\nsystems\tO\nin\tO\nthe\tO\npathophysiology\tO\nof\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesias\tB-Disease\n.\tO\n\nEffects\tO\nof\tO\npallidal\tO\nneurotensin\tB-Chemical\non\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\nparkinsonian\tB-Disease\ncatalepsy\tI-Disease\n:\tO\nbehavioral\tO\nand\tO\nelectrophysiological\tO\nstudies\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\nglobus\tO\npallidus\tO\nplays\tO\na\tO\ncritical\tO\nrole\tO\nin\tO\nmovement\tO\nregulation\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\nindicated\tO\nthat\tO\nthe\tO\nglobus\tO\npallidus\tO\nreceives\tO\nneurotensinergic\tO\ninnervation\tO\nfrom\tO\nthe\tO\nstriatum\tO\n,\tO\nand\tO\nsystemic\tO\nadministration\tO\nof\tO\na\tO\nneurotensin\tB-Chemical\nanalog\tO\ncould\tO\nproduce\tO\nantiparkinsonian\tO\neffects\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\naimed\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\npallidal\tO\nneurotensin\tB-Chemical\non\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\nparkinsonian\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nBehavioral\tO\nexperiments\tO\nand\tO\nelectrophysiological\tO\nrecordings\tO\nwere\tO\nperformed\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nBilateral\tO\ninfusions\tO\nof\tO\nneurotensin\tB-Chemical\ninto\tO\nthe\tO\nglobus\tO\npallidus\tO\nreversed\tO\nhaloperidol\tB-Chemical\n-\tO\ninduced\tO\nparkinsonian\tB-Disease\ncatalepsy\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nElectrophysiological\tO\nrecordings\tO\nshowed\tO\nthat\tO\nmicroinjection\tO\nof\tO\nneurotensin\tB-Chemical\ninduced\tO\nexcitation\tO\nof\tO\npallidal\tO\nneurons\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nsystemic\tO\nhaloperidol\tB-Chemical\nadministration\tO\n.\tO\n\nThe\tO\nneurotensin\tB-Chemical\ntype\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\nreceptor\tI-Chemical\nantagonist\tI-Chemical\nSR48692\tB-Chemical\nblocked\tO\nboth\tO\nthe\tO\nbehavioral\tO\nand\tO\nthe\tO\nelectrophysiological\tO\neffects\tO\ninduced\tO\nby\tO\nneurotensin\tB-Chemical\n.\tO\n\nCONCLUSION\tO\n:\tO\nActivation\tO\nof\tO\npallidal\tO\nneurotensin\tB-Chemical\nreceptors\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nneurotensin\tB-Chemical\n-\tO\ninduced\tO\nantiparkinsonian\tO\neffects\tO\n.\tO\n\nCarmofur\tB-Chemical\n-\tO\ninduced\tO\norganic\tB-Disease\nmental\tI-Disease\ndisorders\tI-Disease\n.\tO\n\nOrganic\tB-Disease\nmental\tI-Disease\ndisorder\tI-Disease\nwas\tO\nobserved\tO\nin\tO\na\tO\n29\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nfemale\tO\nin\tO\nthe\tO\nprognostic\tO\nperiod\tO\nafter\tO\nthe\tO\nonset\tO\nof\tO\ncarmofur\tB-Chemical\n-\tO\ninduced\tO\nleukoencephalopathy\tB-Disease\n.\tO\n\nSymptoms\tO\nsuch\tO\nas\tO\neuphoria\tO\n,\tO\nemotional\tO\nlability\tO\nand\tO\npuerile\tO\nattitude\tO\nnoted\tO\nin\tO\nthe\tO\npatient\tO\nwere\tO\ndiagnosed\tO\nas\tO\norganic\tB-Disease\npersonality\tI-Disease\nsyndrome\tI-Disease\naccording\tO\nto\tO\nthe\tO\ncriteria\tO\ndefined\tO\nin\tO\nthe\tO\nDSM\tO\n-\tO\nIII\tO\n-\tO\nR\tO\n.\tO\n\nIt\tO\nis\tO\nreferred\tO\nto\tO\nas\tO\na\tO\nfrontal\tB-Disease\nlobe\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nBrain\tO\nCT\tO\nrevealed\tO\na\tO\nperiventricular\tO\nlow\tO\ndensity\tO\narea\tO\nin\tO\nthe\tO\nfrontal\tO\nwhite\tO\nmatter\tO\nand\tO\nmoderate\tO\ndilatation\tO\nof\tO\nthe\tO\nlateral\tO\nventricles\tO\nespecially\tO\nat\tO\nthe\tO\nbilateral\tO\nanterior\tO\nhorns\tO\n.\tO\n\nConsequently\tO\n,\tO\ncarmofur\tB-Chemical\n-\tO\ninduced\tO\nleukoencephalopathy\tB-Disease\nmay\tO\nuncommonly\tO\nresult\tO\nin\tO\norganic\tB-Disease\npersonality\tI-Disease\nsyndrome\tI-Disease\nin\tO\nthe\tO\nresidual\tO\nstate\tO\n.\tO\n\nIt\tO\nmay\tO\nbe\tO\nattributed\tO\nto\tO\nthe\tO\nstructural\tB-Disease\ndamage\tI-Disease\nto\tI-Disease\nthe\tI-Disease\nfrontal\tI-Disease\nlobe\tI-Disease\n.\tO\n\nButyrylcholinesterase\tO\ngene\tO\nmutations\tO\nin\tO\npatients\tO\nwith\tO\nprolonged\tO\napnea\tB-Disease\nafter\tO\nsuccinylcholine\tB-Chemical\nfor\tO\nelectroconvulsive\tO\ntherapy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\npatients\tO\nundergoing\tO\nelectroconvulsive\tO\ntherapy\tO\n(\tO\nECT\tO\n)\tO\noften\tO\nreceive\tO\nsuccinylcholine\tB-Chemical\nas\tO\npart\tO\nof\tO\nthe\tO\nanesthetic\tO\nprocedure\tO\n.\tO\n\nThe\tO\nduration\tO\nof\tO\naction\tO\nmay\tO\nbe\tO\nprolonged\tO\nin\tO\npatients\tO\nwith\tO\ngenetic\tO\nvariants\tO\nof\tO\nthe\tO\nbutyrylcholinesterase\tO\nenzyme\tO\n(\tO\nBChE\tO\n)\tO\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nbeing\tO\nthe\tO\nK\tO\n-\tO\nand\tO\nthe\tO\nA\tO\n-\tO\nvariants\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\nassess\tO\nthe\tO\nclinical\tO\nsignificance\tO\nof\tO\ngenetic\tO\nvariants\tO\nin\tO\nbutyrylcholinesterase\tO\ngene\tO\n(\tO\nBCHE\tO\n)\tO\nin\tO\npatients\tO\nwith\tO\na\tO\nsuspected\tO\nprolonged\tO\nduration\tO\nof\tO\naction\tO\nof\tO\nsuccinylcholine\tB-Chemical\nafter\tO\nECT\tO\n.\tO\n\nMETHODS\tO\n:\tO\na\tO\ntotal\tO\nof\tO\n13\tO\npatients\tO\nwere\tO\nreferred\tO\nto\tO\nthe\tO\nDanish\tO\nCholinesterase\tO\nResearch\tO\nUnit\tO\nafter\tO\nECT\tO\nduring\tO\n38\tO\nmonths\tO\n.\tO\n\nWe\tO\ndetermined\tO\nthe\tO\nBChE\tO\nactivity\tO\nand\tO\nthe\tO\nBCHE\tO\ngenotype\tO\nusing\tO\nmolecular\tO\ngenetic\tO\nmethods\tO\n,\tO\nthe\tO\nduration\tO\nof\tO\napnea\tB-Disease\n,\tO\ntime\tO\nto\tO\nsufficient\tO\nspontaneous\tO\nventilation\tO\nand\tO\nwhether\tO\nneuromuscular\tO\nmonitoring\tO\nwas\tO\nused\tO\n.\tO\n\nThe\tO\nduration\tO\nof\tO\napnea\tB-Disease\nwas\tO\ncompared\tO\nwith\tO\npublished\tO\ndata\tO\non\tO\nnormal\tO\nsubjects\tO\n.\tO\n\nRESULTS\tO\n:\tO\nin\tO\n11\tO\npatients\tO\n,\tO\nmutations\tO\nwere\tO\nfound\tO\nin\tO\nthe\tO\nBCHE\tO\ngene\tO\n,\tO\nthe\tO\nK\tO\n-\tO\nvariant\tO\nbeing\tO\nthe\tO\nmost\tO\nfrequent\tO\n.\tO\n\nThe\tO\nduration\tO\nof\tO\napnea\tB-Disease\nwas\tO\n5\tO\n-\tO\n15\tO\nmin\tO\ncompared\tO\nwith\tO\n3\tO\n-\tO\n5\tO\n.\tO\n3\tO\nmin\tO\nfrom\tO\nthe\tO\nliterature\tO\n.\tO\n\nSevere\tO\ndistress\tO\nwas\tO\nnoted\tO\nin\tO\nthe\tO\nrecovery\tO\nphase\tO\nin\tO\ntwo\tO\npatients\tO\n.\tO\n\nNeuromuscular\tO\nmonitoring\tO\nwas\tO\nused\tO\nin\tO\ntwo\tO\npatients\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\neleven\tO\nof\tO\n13\tO\npatients\tO\nwith\tO\na\tO\nprolonged\tO\nduration\tO\nof\tO\naction\tO\nof\tO\nsuccinylcholine\tB-Chemical\nhad\tO\nmutations\tO\nin\tO\nBCHE\tO\n,\tO\nindicating\tO\nthat\tO\nthis\tO\nis\tO\nthe\tO\npossible\tO\nreason\tO\nfor\tO\na\tO\nprolonged\tO\nperiod\tO\nof\tO\napnea\tB-Disease\n.\tO\n\nWe\tO\nrecommend\tO\nobjective\tO\nneuromuscular\tO\nmonitoring\tO\nduring\tO\nthe\tO\nfirst\tO\nECT\tO\n.\tO\n\nPerhexiline\tB-Chemical\nmaleate\tI-Chemical\nand\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nPeripheral\tB-Disease\nneuropathy\tI-Disease\nhas\tO\nbeen\tO\nnoted\tO\nas\tO\na\tO\ncomplication\tO\nof\tO\ntherapy\tO\nwith\tO\nperhexiline\tB-Chemical\nmaleate\tI-Chemical\n,\tO\na\tO\ndrug\tO\nwidely\tO\nused\tO\nin\tO\nFrance\tO\n(\tO\nand\tO\nin\tO\nclinical\tO\ntrials\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n)\tO\nfor\tO\nthe\tO\nprophylactic\tO\ntreatment\tO\nof\tO\nangina\tB-Disease\npectoris\tI-Disease\n.\tO\n\nIn\tO\n24\tO\npatients\tO\nwith\tO\nthis\tO\ncomplication\tO\n,\tO\nthe\tO\nmarked\tO\nslowing\tO\nof\tO\nmotor\tO\nnerve\tO\nconduction\tO\nvelocity\tO\nand\tO\nthe\tO\nelectromyographic\tO\nchanges\tO\nimply\tO\nmainly\tO\na\tO\ndemyelinating\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nImprovement\tO\nwas\tO\nnoted\tO\nwith\tO\ncessation\tO\nof\tO\ntherapy\tO\n.\tO\n\nIn\tO\na\tO\nfew\tO\ncases\tO\nthe\tO\npresence\tO\nof\tO\nactive\tO\ndenervation\tO\nsignified\tO\na\tO\npoor\tO\nprognosis\tO\n,\tO\nwith\tO\nonly\tO\nslight\tO\nimprovement\tO\n.\tO\n\nThe\tO\nunderlying\tO\nmechanism\tO\ncausing\tO\nthe\tO\nneuropathy\tB-Disease\nis\tO\nnot\tO\nyet\tO\nfully\tO\nknown\tO\n,\tO\nalthough\tO\nsome\tO\nevidence\tO\nindicates\tO\nthat\tO\nit\tO\nmay\tO\nbe\tO\na\tO\nlipid\tO\nstorage\tO\nprocess\tO\n.\tO\n\nA\tO\nphase\tO\nI\tO\nstudy\tO\nof\tO\n4\tB-Chemical\n'\tI-Chemical\n-\tI-Chemical\n0\tI-Chemical\n-\tI-Chemical\ntetrahydropyranyladriamycin\tI-Chemical\n.\tO\n\nClinical\tO\npharmacology\tO\nand\tO\npharmacokinetics\tO\n.\tO\n\nA\tO\nPhase\tO\nI\tO\nstudy\tO\nof\tO\nintravenous\tO\n(\tO\nIV\tO\n)\tO\nbolus\tO\n4\tB-Chemical\n'\tI-Chemical\n-\tI-Chemical\n0\tI-Chemical\n-\tI-Chemical\ntetrahydropyranyladriamycin\tI-Chemical\n(\tO\nPirarubicin\tB-Chemical\n)\tO\nwas\tO\ndone\tO\nin\tO\n55\tO\npatients\tO\nin\tO\ngood\tO\nperformance\tO\nstatus\tO\nwith\tO\nrefractory\tO\ntumors\tB-Disease\n.\tO\n\nTwenty\tO\n-\tO\nsix\tO\nhad\tO\nminimal\tO\nprior\tO\ntherapy\tO\n(\tO\ngood\tO\nrisk\tO\n)\tO\n,\tO\n23\tO\nhad\tO\nextensive\tO\nprior\tO\ntherapy\tO\n(\tO\npoor\tO\nrisk\tO\n)\tO\n,\tO\nand\tO\nsix\tO\nhad\tO\nrenal\tB-Disease\nand\tI-Disease\n/\tI-Disease\nor\tI-Disease\nhepatic\tI-Disease\ndysfunction\tI-Disease\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n167\tO\ncourses\tO\nat\tO\ndoses\tO\nof\tO\n15\tO\nto\tO\n70\tO\nmg\tO\n/\tO\nm2\tO\nwere\tO\nevaluable\tO\n.\tO\n\nMaximum\tO\ntolerated\tO\ndose\tO\nin\tO\ngood\tO\n-\tO\nrisk\tO\npatients\tO\nwas\tO\n70\tO\nmg\tO\n/\tO\nm2\tO\n,\tO\nand\tO\nin\tO\npoor\tO\n-\tO\nrisk\tO\npatients\tO\n,\tO\n60\tO\nmg\tO\n/\tO\nm2\tO\n.\tO\n\nThe\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxic\tO\neffect\tO\nwas\tO\ntransient\tO\nnoncumulative\tO\ngranulocytopenia\tB-Disease\n.\tO\n\nGranulocyte\tO\nnadir\tO\nwas\tO\non\tO\nday\tO\n14\tO\n(\tO\nrange\tO\n,\tO\n4\tO\n-\tO\n22\tO\n)\tO\n.\tO\n\nLess\tO\nfrequent\tO\ntoxic\tO\neffects\tO\nincluded\tO\nthrombocytopenia\tB-Disease\n,\tO\nanemia\tB-Disease\n,\tO\nnausea\tB-Disease\n,\tO\nmild\tO\nalopecia\tB-Disease\n,\tO\nphlebitis\tB-Disease\n,\tO\nand\tO\nmucositis\tB-Disease\n.\tO\n\nMyelosuppression\tB-Disease\nwas\tO\nmore\tO\nin\tO\npatients\tO\nwith\tO\nhepatic\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nPharmacokinetic\tO\nanalyses\tO\nin\tO\n21\tO\npatients\tO\nrevealed\tO\nPirarubicin\tB-Chemical\nplasma\tO\nT\tO\n1\tO\n/\tO\n2\tO\nalpha\tO\n(\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\nof\tO\n2\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n85\tO\nminutes\tO\n,\tO\nT\tO\nbeta\tO\n1\tO\n/\tO\n2\tO\nof\tO\n25\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n5\tO\nminutes\tO\n,\tO\nand\tO\nT\tO\n1\tO\n/\tO\n2\tO\ngamma\tO\nof\tO\n23\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n7\tO\n.\tO\n6\tO\nhours\tO\n.\tO\n\nThe\tO\narea\tO\nunder\tO\nthe\tO\ncurve\tO\nwas\tO\n537\tO\n+\tO\n/\tO\n-\tO\n149\tO\nng\tO\n/\tO\nml\tO\nx\tO\nhours\tO\n,\tO\nvolume\tO\nof\tO\ndistribution\tO\n(\tO\nVd\tO\n)\tO\n3504\tO\n+\tO\n/\tO\n-\tO\n644\tO\nl\tO\n/\tO\nm2\tO\n,\tO\nand\tO\ntotal\tO\nclearance\tO\n(\tO\nClT\tO\n)\tO\nwas\tO\n204\tO\n+\tO\n39\tO\n.\tO\n3\tO\nl\tO\n/\tO\nhour\tO\n/\tO\nm2\tO\n.\tO\n\nAdriamycinol\tB-Chemical\n,\tO\ndoxorubicin\tB-Chemical\n,\tO\nadriamycinone\tB-Chemical\n,\tO\nand\tO\ntetrahydropyranyladriamycinol\tB-Chemical\nwere\tO\nthe\tO\nmetabolites\tO\ndetected\tO\nin\tO\nplasma\tO\nand\tO\nthe\tO\namount\tO\nof\tO\ndoxorubicin\tB-Chemical\nwas\tO\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n10\tO\n%\tO\nof\tO\nthe\tO\ntotal\tO\nmetabolites\tO\n.\tO\n\nUrinary\tO\nexcretion\tO\nof\tO\nPirarubicin\tB-Chemical\nin\tO\nthe\tO\nfirst\tO\n24\tO\nhours\tO\nwas\tO\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n10\tO\n%\tO\n.\tO\n\nActivity\tO\nwas\tO\nnoted\tO\nin\tO\nmesothelioma\tB-Disease\n,\tO\nleiomyosarcoma\tB-Disease\n,\tO\nand\tO\nbasal\tB-Disease\ncell\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nThe\tO\nrecommended\tO\nstarting\tO\ndose\tO\nfor\tO\nPhase\tO\nII\tO\ntrials\tO\nis\tO\n60\tO\nmg\tO\n/\tO\nm2\tO\nIV\tO\nbolus\tO\nevery\tO\n3\tO\nweeks\tO\n.\tO\n\nOcular\tB-Disease\nand\tI-Disease\nauditory\tI-Disease\ntoxicity\tI-Disease\nin\tO\nhemodialyzed\tO\npatients\tO\nreceiving\tO\ndesferrioxamine\tB-Chemical\n.\tO\n\nDuring\tO\nan\tO\n18\tO\n-\tO\nmonth\tO\nperiod\tO\nof\tO\nstudy\tO\n41\tO\nhemodialyzed\tO\npatients\tO\nreceiving\tO\ndesferrioxamine\tB-Chemical\n(\tO\n10\tO\n-\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n/\tO\n3\tO\ntimes\tO\nweekly\tO\n)\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nwere\tO\nmonitored\tO\nfor\tO\ndetection\tO\nof\tO\naudiovisual\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\n6\tO\npatients\tO\npresented\tO\nclinical\tO\nsymptoms\tO\nof\tO\nvisual\tB-Disease\nor\tI-Disease\nauditory\tI-Disease\ntoxicity\tI-Disease\n.\tO\n\nMoreover\tO\n,\tO\ndetailed\tO\nophthalmologic\tO\nand\tO\naudiologic\tO\nstudies\tO\ndisclosed\tO\nabnormalities\tO\nin\tO\n7\tO\nmore\tO\nasymptomatic\tO\npatients\tO\n.\tO\n\nVisual\tB-Disease\ntoxicity\tI-Disease\nwas\tO\nof\tO\nretinal\tO\norigin\tO\nand\tO\nwas\tO\ncharacterized\tO\nby\tO\na\tO\ntritan\tO\n-\tO\ntype\tO\ndyschromatopsy\tB-Disease\n,\tO\nsometimes\tO\nassociated\tO\nwith\tO\na\tB-Disease\nloss\tI-Disease\nof\tI-Disease\nvisual\tI-Disease\nacuity\tI-Disease\nand\tO\npigmentary\tB-Disease\nretinal\tI-Disease\ndeposits\tI-Disease\n.\tO\n\nAuditory\tB-Disease\ntoxicity\tI-Disease\nwas\tO\ncharacterized\tO\nby\tO\na\tO\nmid\tO\n-\tO\nto\tO\nhigh\tO\n-\tO\nfrequency\tO\nneurosensorial\tB-Disease\nhearing\tI-Disease\nloss\tI-Disease\nand\tO\nthe\tO\nlesion\tO\nwas\tO\nof\tO\nthe\tO\ncochlear\tO\ntype\tO\n.\tO\n\nDesferrioxamine\tB-Chemical\nwithdrawal\tO\nresulted\tO\nin\tO\na\tO\ncomplete\tO\nrecovery\tO\nof\tO\nvisual\tO\nfunction\tO\nin\tO\n1\tO\npatient\tO\nand\tO\npartial\tO\nrecovery\tO\nin\tO\n3\tO\n,\tO\nand\tO\na\tO\ncomplete\tO\nreversal\tO\nof\tO\nhearing\tB-Disease\nloss\tI-Disease\nin\tO\n3\tO\npatients\tO\nand\tO\npartial\tO\nrecovery\tO\nin\tO\n3\tO\n.\tO\n\nThis\tO\ntoxicity\tB-Disease\nappeared\tO\nin\tO\npatients\tO\nreceiving\tO\nthe\tO\nhigher\tO\ndoses\tO\nof\tO\ndesferrioxamine\tB-Chemical\nor\tO\ncoincided\tO\nwith\tO\nthe\tO\nnormalization\tO\nof\tO\nferritin\tO\nor\tO\naluminium\tB-Chemical\nserum\tO\nlevels\tO\n.\tO\n\nThe\tO\ndata\tO\nindicate\tO\nthat\tO\naudiovisual\tB-Disease\ntoxicity\tI-Disease\nis\tO\nnot\tO\nan\tO\ninfrequent\tO\ncomplication\tO\nin\tO\nhemodialyzed\tO\npatients\tO\nreceiving\tO\ndesferrioxamine\tB-Chemical\n.\tO\n\nPeriodical\tO\naudiovisual\tO\nmonitoring\tO\nshould\tO\nbe\tO\nperformed\tO\non\tO\nhemodialyzed\tO\npatients\tO\nreceiving\tO\nthe\tO\ndrug\tO\nin\tO\norder\tO\nto\tO\ndetect\tO\nadverse\tO\neffects\tO\nas\tO\nearly\tO\nas\tO\npossible\tO\n.\tO\n\nSerial\tO\nepilepsy\tB-Disease\ncaused\tO\nby\tO\nlevodopa\tB-Chemical\n/\tI-Chemical\ncarbidopa\tI-Chemical\nadministration\tO\nin\tO\ntwo\tO\npatients\tO\non\tO\nhemodialysis\tO\n.\tO\n\nTwo\tO\npatients\tO\nwith\tO\nsimilar\tO\nclinical\tO\nfeatures\tO\nare\tO\npresented\tO\n:\tO\nboth\tO\npatients\tO\nhad\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\non\tO\nhemodialysis\tO\nfor\tO\nmany\tO\nyears\tO\nbut\tO\nrecently\tO\nbegun\tO\non\tO\na\tO\nhigh\tO\n-\tO\nflux\tO\ndialyzer\tO\n;\tO\nboth\tO\nhad\tO\nbeen\tO\nreceiving\tO\na\tO\ncarbidopa\tB-Chemical\n/\tI-Chemical\nlevodopa\tI-Chemical\npreparation\tO\n;\tO\nand\tO\nboth\tO\nhad\tO\nthe\tO\nonset\tO\nof\tO\nhallucinosis\tB-Disease\nand\tO\nrecurrent\tO\nseizures\tB-Disease\n,\tO\nwhich\tO\nwere\tO\nrefractory\tO\nto\tO\nanticonvulsants\tO\n.\tO\n\nThe\tO\nfirst\tO\npatient\tO\ndied\tO\nwithout\tO\na\tO\ndiagnosis\tO\n;\tO\nthe\tO\nsecond\tO\npatient\tO\nhad\tO\na\tO\ndramatic\tO\nrecovery\tO\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nvitamin\tB-Chemical\nB6\tI-Chemical\n.\tO\n\nNeither\tO\npatient\tO\nwas\tO\nconsidered\tO\nto\tO\nhave\tO\na\tO\nrenal\tO\nstate\tO\nsufficiently\tO\nsevere\tO\nenough\tO\nto\tO\nexplain\tO\ntheir\tO\npresentation\tO\n.\tO\n\nRandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\ntrial\tO\nof\tO\nmazindol\tB-Chemical\nin\tO\nDuchenne\tB-Disease\ndystrophy\tI-Disease\n.\tO\n\nThere\tO\nis\tO\nevidence\tO\nthat\tO\ngrowth\tO\nhormone\tO\nmay\tO\nbe\tO\nrelated\tO\nto\tO\nthe\tO\nprogression\tO\nof\tO\nweakness\tB-Disease\nin\tO\nDuchenne\tB-Disease\ndystrophy\tI-Disease\n.\tO\n\nWe\tO\nconducted\tO\na\tO\n12\tO\n-\tO\nmonth\tO\ncontrolled\tO\ntrial\tO\nof\tO\nmazindol\tB-Chemical\n,\tO\na\tO\nputative\tO\ngrowth\tO\nhormone\tO\nsecretion\tO\ninhibitor\tO\n,\tO\nin\tO\n83\tO\nboys\tO\nwith\tO\nDuchenne\tB-Disease\ndystrophy\tI-Disease\n.\tO\n\nMuscle\tO\nstrength\tO\n,\tO\ncontractures\tO\n,\tO\nfunctional\tO\nability\tO\nand\tO\npulmonary\tO\nfunction\tO\nwere\tO\ntested\tO\nat\tO\nbaseline\tO\n,\tO\nand\tO\n6\tO\nand\tO\n12\tO\nmonths\tO\nafter\tO\ntreatment\tO\nwith\tO\nmazindol\tB-Chemical\n(\tO\n3\tO\nmg\tO\n/\tO\nd\tO\n)\tO\nor\tO\nplacebo\tO\n.\tO\n\nThe\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nhave\tO\na\tO\npower\tO\nof\tO\ngreater\tO\nthan\tO\n0\tO\n.\tO\n90\tO\nto\tO\ndetect\tO\na\tO\nslowing\tO\nto\tO\n25\tO\n%\tO\nof\tO\nthe\tO\nexpected\tO\nrate\tO\nof\tO\nprogression\tO\nof\tO\nweakness\tB-Disease\nat\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n.\tO\n\nMazindol\tB-Chemical\ndid\tO\nnot\tO\nbenefit\tO\nstrength\tO\nat\tO\nany\tO\npoint\tO\nin\tO\nthe\tO\nstudy\tO\n.\tO\n\nSide\tO\neffects\tO\nattributable\tO\nto\tO\nmazindol\tB-Chemical\nincluded\tO\ndecreased\tB-Disease\nappetite\tI-Disease\n(\tO\n36\tO\n%\tO\n)\tO\n,\tO\ndry\tB-Disease\nmouth\tI-Disease\n(\tO\n10\tO\n%\tO\n)\tO\n,\tO\nbehavioral\tO\nchange\tO\n(\tO\n22\tO\n%\tO\n)\tO\n,\tO\nand\tO\ngastrointestinal\tB-Disease\nsymptoms\tI-Disease\n(\tO\n18\tO\n%\tO\n)\tO\n;\tO\nmazindol\tB-Chemical\ndosage\tO\nwas\tO\nreduced\tO\nin\tO\n43\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nmazindol\tB-Chemical\non\tO\nGH\tO\nsecretion\tO\nwas\tO\nestimated\tO\nindirectly\tO\nby\tO\ncomparing\tO\nthe\tO\npostabsorptive\tO\nIGF\tO\n-\tO\nI\tO\nlevels\tO\nobtained\tO\nfollowing\tO\n3\tO\n,\tO\n6\tO\n,\tO\n9\tO\n,\tO\nand\tO\n12\tO\nmonths\tO\nin\tO\nthe\tO\nmazindol\tB-Chemical\ntreated\tO\nto\tO\nthose\tO\nin\tO\nthe\tO\nplacebo\tO\ngroups\tO\n.\tO\n\nAlthough\tO\nmazindol\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\ngained\tO\nless\tO\nweight\tO\nand\tO\nheight\tO\nthan\tO\nplacebo\tO\n-\tO\ntreated\tO\npatients\tO\n,\tO\nno\tO\nsignificant\tO\neffect\tO\non\tO\nIGF\tO\n-\tO\nI\tO\nlevels\tO\nwas\tO\nobserved\tO\n.\tO\n\nMazindol\tB-Chemical\ndoses\tO\nnot\tO\nslow\tO\nthe\tO\nprogression\tO\nof\tO\nweakness\tB-Disease\nin\tO\nDuchenne\tB-Disease\ndystrophy\tI-Disease\n.\tO\n\nFacilitation\tO\nof\tO\nmemory\tO\nretrieval\tO\nby\tO\npre\tO\n-\tO\ntest\tO\nmorphine\tB-Chemical\nand\tO\nits\tO\nstate\tO\ndependency\tO\nin\tO\nthe\tO\nstep\tO\n-\tO\nthrough\tO\ntype\tO\npassive\tO\navoidance\tO\nlearning\tO\ntest\tO\nin\tO\nmice\tO\n.\tO\n\nAmnesia\tB-Disease\nproduced\tO\nby\tO\nscopolamine\tB-Chemical\nand\tO\ncycloheximide\tB-Chemical\nwere\tO\nreversed\tO\nby\tO\nmorphine\tB-Chemical\ngiven\tO\n30\tO\nmin\tO\nbefore\tO\nthe\tO\ntest\tO\ntrial\tO\n(\tO\npre\tO\n-\tO\ntest\tO\n)\tO\n,\tO\nand\tO\npre\tO\n-\tO\ntest\tO\nmorphine\tB-Chemical\nalso\tO\nfacilitated\tO\nthe\tO\nmemory\tO\nretrieval\tO\nin\tO\nthe\tO\nanimals\tO\nadministered\tO\nnaloxone\tB-Chemical\nduring\tO\nthe\tO\ntraining\tO\ntrial\tO\n.\tO\n\nSimilarly\tO\n,\tO\npre\tO\n-\tO\ntest\tO\nscopolamine\tB-Chemical\npartially\tO\nreversed\tO\nthe\tO\nscopolamine\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\n,\tO\nbut\tO\nnot\tO\nsignificantly\tO\n;\tO\nand\tO\npre\tO\n-\tO\ntest\tO\ncycloheximide\tB-Chemical\nfailed\tO\nto\tO\nreverse\tO\nthe\tO\ncycloheximide\tB-Chemical\n-\tO\ninduced\tO\namnesia\tB-Disease\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nthe\tO\nfacilitation\tO\nof\tO\nmemory\tO\nretrieval\tO\nby\tO\npre\tO\n-\tO\ntest\tO\nmorphine\tB-Chemical\nmight\tO\nbe\tO\nthe\tO\ndirect\tO\naction\tO\nof\tO\nmorphine\tB-Chemical\nrather\tO\nthan\tO\na\tO\nstate\tO\ndependent\tO\neffect\tO\n.\tO\n\nNaloxone\tB-Chemical\nreverses\tO\nthe\tO\nantihypertensive\tO\neffect\tO\nof\tO\nclonidine\tB-Chemical\n.\tO\n\nIn\tO\nunanesthetized\tO\n,\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\nthe\tO\ndecrease\tO\nin\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\nproduced\tO\nby\tO\nintravenous\tO\nclonidine\tB-Chemical\n,\tO\n5\tO\nto\tO\n20\tO\nmicrograms\tO\n/\tO\nkg\tO\n,\tO\nwas\tO\ninhibited\tO\nor\tO\nreversed\tO\nby\tO\nnalozone\tB-Chemical\n,\tO\n0\tO\n.\tO\n2\tO\nto\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nThe\tO\nhypotensive\tB-Disease\neffect\tO\nof\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyldopa\tI-Chemical\nwas\tO\nalso\tO\npartially\tO\nreversed\tO\nby\tO\nnaloxone\tB-Chemical\n.\tO\n\nNaloxone\tB-Chemical\nalone\tO\ndid\tO\nnot\tO\naffect\tO\neither\tO\nblood\tO\npressure\tO\nor\tO\nheart\tO\nrate\tO\n.\tO\n\nIn\tO\nbrain\tO\nmembranes\tO\nfrom\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\nclonidine\tB-Chemical\n,\tO\n10\tO\n(\tO\n-\tO\n8\tO\n)\tO\nto\tO\n10\tO\n(\tO\n-\tO\n5\tO\n)\tO\nM\tO\n,\tO\ndid\tO\nnot\tO\ninfluence\tO\nstereoselective\tO\nbinding\tO\nof\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nnaloxone\tI-Chemical\n(\tO\n8\tO\nnM\tO\n)\tO\n,\tO\nand\tO\nnaloxone\tB-Chemical\n,\tO\n10\tO\n(\tO\n-\tO\n8\tO\n)\tO\nto\tO\n10\tO\n(\tO\n-\tO\n4\tO\n)\tO\nM\tO\n,\tO\ndid\tO\nnot\tO\ninfluence\tO\nclonidine\tB-Chemical\n-\tO\nsuppressible\tO\nbinding\tO\nof\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\ndihydroergocryptine\tI-Chemical\n(\tO\n1\tO\nnM\tO\n)\tO\n.\tO\n\nThese\tO\nfindings\tO\nindicate\tO\nthat\tO\nin\tO\nspontaneously\tO\nhypertensive\tB-Disease\nrats\tO\nthe\tO\neffects\tO\nof\tO\ncentral\tO\nalpha\tO\n-\tO\nadrenoceptor\tO\nstimulation\tO\ninvolve\tO\nactivation\tO\nof\tO\nopiate\tO\nreceptors\tO\n.\tO\n\nAs\tO\nnaloxone\tB-Chemical\nand\tO\nclonidine\tB-Chemical\ndo\tO\nnot\tO\nappear\tO\nto\tO\ninteract\tO\nwith\tO\nthe\tO\nsame\tO\nreceptor\tO\nsite\tO\n,\tO\nthe\tO\nobserved\tO\nfunctional\tO\nantagonism\tO\nsuggests\tO\nthe\tO\nrelease\tO\nof\tO\nan\tO\nendogenous\tO\nopiate\tO\nby\tO\nclonidine\tB-Chemical\nor\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyldopa\tI-Chemical\nand\tO\nthe\tO\npossible\tO\nrole\tO\nof\tO\nthe\tO\nopiate\tO\nin\tO\nthe\tO\ncentral\tO\ncontrol\tO\nof\tO\nsympathetic\tO\ntone\tO\n.\tO\n\nNeurotoxicity\tB-Disease\nof\tO\nhalogenated\tB-Chemical\nhydroxyquinolines\tI-Chemical\n:\tO\nclinical\tO\nanalysis\tO\nof\tO\ncases\tO\nreported\tO\noutside\tO\nJapan\tO\n.\tO\n\nAn\tO\nanalysis\tO\nis\tO\npresented\tO\nof\tO\n220\tO\ncases\tO\nof\tO\npossible\tO\nneurotoxic\tB-Disease\nreactions\tO\nto\tO\nhalogenated\tB-Chemical\nhydroxyquinolines\tI-Chemical\nreported\tO\nfrom\tO\noutside\tO\nJapan\tO\n.\tO\n\nIn\tO\n80\tO\ncases\tO\ninsufficient\tO\ninformation\tO\nwas\tO\navailable\tO\nfor\tO\nadequate\tO\ncomment\tO\nand\tO\nin\tO\n29\tO\na\tO\nrelationship\tO\nto\tO\nthe\tO\nadministration\tO\nof\tO\nclioquinol\tB-Chemical\ncould\tO\nbe\tO\nexcluded\tO\n.\tO\n\nOf\tO\nthe\tO\nremainder\tO\n,\tO\na\tO\nrelationship\tO\nto\tO\nclioquinol\tB-Chemical\nwas\tO\nconsidered\tO\nprobable\tO\nin\tO\n42\tO\nand\tO\npossible\tO\nin\tO\n69\tO\ncases\tO\n.\tO\n\nIn\tO\nsix\tO\nof\tO\nthe\tO\nprobable\tO\ncases\tO\nthe\tO\nneurological\tB-Disease\ndisturbance\tI-Disease\nconsisted\tO\nof\tO\nan\tO\nacute\tO\nreversible\tO\nencephalopathy\tB-Disease\nusually\tO\nrelated\tO\nto\tO\nthe\tO\ningestion\tO\nof\tO\na\tO\nhigh\tO\ndose\tO\nof\tO\nclioquinol\tB-Chemical\nover\tO\na\tO\nshort\tO\nperiod\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nmanifestation\tO\n,\tO\nobserved\tO\nin\tO\n15\tO\nfurther\tO\ncases\tO\n,\tO\nwas\tO\nisolated\tO\noptic\tB-Disease\natrophy\tI-Disease\n.\tO\n\nThis\tO\nwas\tO\nmost\tO\nfrequently\tO\nfound\tO\nin\tO\nchildren\tO\n,\tO\nmany\tO\nof\tO\nwhom\tO\nhad\tO\nreceived\tO\nclioquinol\tB-Chemical\nas\tO\ntreatment\tO\nfor\tO\nacrodermatitis\tB-Disease\nenteropathica\tI-Disease\n.\tO\n\nIn\tO\nthe\tO\nremaining\tO\ncases\tO\n,\tO\na\tO\ncombination\tO\nof\tO\nmyelopathy\tB-Disease\n,\tO\nvisual\tB-Disease\ndisturbance\tI-Disease\n,\tO\nand\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\nwas\tO\nthe\tO\nmost\tO\ncommon\tO\nmanifestation\tO\n.\tO\n\nIsolated\tO\nmyelopathy\tB-Disease\nor\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\n,\tO\nor\tO\nthese\tO\nmanifestations\tO\noccurring\tO\ntogether\tO\n,\tO\nwere\tO\ninfrequent\tO\n.\tO\n\nThe\tO\nonset\tO\nof\tO\nall\tO\nmanifestations\tO\n(\tO\nexcept\tO\ntoxic\tO\nencephalopathy\tB-Disease\n)\tO\nwas\tO\nusually\tO\nsubacute\tO\n,\tO\nwith\tO\nsubsequent\tO\npartial\tO\nrecovery\tO\n.\tO\n\nOlder\tO\nsubjects\tO\ntended\tO\nto\tO\ndisplay\tO\nmore\tO\nside\tO\neffects\tO\n.\tO\n\nThe\tO\nfull\tO\nsyndrome\tO\nof\tO\nsubacute\tO\nmyelo\tB-Disease\n-\tI-Disease\noptic\tI-Disease\nneuropathy\tI-Disease\nwas\tO\nmore\tO\nfrequent\tO\nin\tO\nwomen\tO\n,\tO\nbut\tO\nthey\tO\ntended\tO\nto\tO\nhave\tO\ntaken\tO\ngreater\tO\nquantities\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nPrazosin\tB-Chemical\n-\tO\ninduced\tO\nstress\tB-Disease\nincontinence\tI-Disease\n.\tO\n\nA\tO\ncase\tO\nof\tO\ngenuine\tO\nstress\tB-Disease\nincontinence\tI-Disease\ndue\tO\nto\tO\nprazosin\tB-Chemical\n,\tO\na\tO\ncommon\tO\nantihypertensive\tO\ndrug\tO\n,\tO\nis\tO\npresented\tO\n.\tO\n\nPrazosin\tB-Chemical\nexerts\tO\nits\tO\nantihypertensive\tO\neffects\tO\nthrough\tO\nvasodilatation\tO\ncaused\tO\nby\tO\nselective\tO\nblockade\tO\nof\tO\npostsynaptic\tO\nalpha\tO\n-\tO\n1\tO\nadrenergic\tO\nreceptors\tO\n.\tO\n\nAs\tO\nan\tO\nalpha\tO\n-\tO\nblocker\tO\n,\tO\nit\tO\nalso\tO\nexerts\tO\na\tO\nsignificant\tO\nrelaxant\tO\neffect\tO\non\tO\nthe\tO\nbladder\tO\nneck\tO\nand\tO\nurethra\tO\n.\tO\n\nThe\tO\npatient\tO\n'\tO\ns\tO\nclinical\tO\ncourse\tO\nis\tO\ndescribed\tO\nand\tO\ncorrelated\tO\nwith\tO\ninitial\tO\nurodynamic\tO\nstudies\tO\nwhile\tO\non\tO\nprazosin\tB-Chemical\nand\tO\nsubsequent\tO\nstudies\tO\nwhile\tO\ntaking\tO\nverapamil\tB-Chemical\n.\tO\n\nHer\tO\nincontinence\tB-Disease\nresolved\tO\nwith\tO\nthe\tO\nchange\tO\nof\tO\nmedication\tO\n.\tO\n\nThe\tO\nrestoration\tO\nof\tO\ncontinence\tO\nwas\tO\naccompanied\tO\nby\tO\na\tO\nsubstantial\tO\nrise\tO\nin\tO\nmaximum\tO\nurethral\tO\npressure\tO\n,\tO\nmaximum\tO\nurethral\tO\nclosure\tO\npressure\tO\n,\tO\nand\tO\nfunctional\tO\nurethral\tO\nlength\tO\n.\tO\n\nPatients\tO\nwho\tO\npresent\tO\nwith\tO\nstress\tB-Disease\nincontinence\tI-Disease\nwhile\tO\ntaking\tO\nprazosin\tB-Chemical\nshould\tO\nchange\tO\ntheir\tO\nantihypertensive\tO\nmedication\tO\nbefore\tO\nconsidering\tO\nsurgery\tO\n,\tO\nbecause\tO\ntheir\tO\nincontinence\tB-Disease\nmay\tO\nresolve\tO\nspontaneously\tO\nwith\tO\na\tO\nchange\tO\nin\tO\ndrug\tO\ntherapy\tO\n.\tO\n\nMyocardial\tB-Disease\ninfarction\tI-Disease\nfollowing\tO\nsublingual\tO\nadministration\tO\nof\tO\nisosorbide\tB-Chemical\ndinitrate\tI-Chemical\n.\tO\n\nA\tO\n78\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwith\tO\nhealed\tO\nseptal\tO\nnecrosis\tB-Disease\nsuffered\tO\na\tO\nrecurrent\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nof\tO\nthe\tO\nanterior\tO\nwall\tO\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nisosorbide\tB-Chemical\ndinitrate\tI-Chemical\n5\tO\nmg\tO\nsublingually\tO\n.\tO\n\nAfter\tO\ndetailing\tO\nthe\tO\ncourse\tO\nof\tO\nevents\tO\n,\tO\nwe\tO\ndiscuss\tO\nthe\tO\nrole\tO\nof\tO\nparadoxical\tO\ncoronary\tO\nspasm\tB-Disease\nand\tO\nhypotension\tB-Disease\n-\tO\nmediated\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\noccurring\tO\ndownstream\tO\nto\tO\nsignificant\tO\ncoronary\tB-Disease\narterial\tI-Disease\nstenosis\tI-Disease\nin\tO\nthe\tO\npathophysiology\tO\nof\tO\nacute\tB-Disease\ncoronary\tI-Disease\ninsufficiency\tI-Disease\n.\tO\n\nComparison\tO\nof\tO\nthe\tO\nrespiratory\tO\neffects\tO\nof\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusions\tO\nof\tO\nmorphine\tB-Chemical\nand\tO\nregional\tO\nanalgesia\tO\nby\tO\nextradural\tO\nblock\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\npostoperative\tO\nrespiratory\tO\napnoea\tB-Disease\nwas\tO\ncompared\tO\nbetween\tO\nfive\tO\npatients\tO\nreceiving\tO\na\tO\ncontinuous\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusion\tO\nof\tO\nmorphine\tB-Chemical\n(\tO\nmean\tO\n73\tO\n.\tO\n6\tO\nmg\tO\n)\tO\nand\tO\nfive\tO\npatients\tO\nreceiving\tO\na\tO\ncontinuous\tO\nextradural\tO\ninfusion\tO\nof\tO\n0\tO\n.\tO\n25\tO\n%\tO\nbupivacaine\tB-Chemical\n(\tO\nmean\tO\n192\tO\nmg\tO\n)\tO\nin\tO\nthe\tO\n24\tO\n-\tO\nh\tO\nperiod\tO\nfollowing\tO\nupper\tO\nabdominal\tO\nsurgery\tO\n.\tO\n\nMonitoring\tO\nconsisted\tO\nof\tO\nairflow\tO\ndetection\tO\nby\tO\na\tO\ncarbon\tB-Chemical\ndioxide\tI-Chemical\nanalyser\tO\n,\tO\nchest\tO\nwall\tO\nmovement\tO\ndetected\tO\nby\tO\npneumatic\tO\ncapsules\tO\n,\tO\nand\tO\ncontinuous\tO\nelectrocardiograph\tO\nrecorded\tO\nwith\tO\na\tO\nHolter\tO\nambulatory\tO\nmonitor\tO\n.\tO\n\nBoth\tO\nobstructive\tB-Disease\n(\tI-Disease\nP\tI-Disease\nless\tI-Disease\nthan\tI-Disease\n0\tI-Disease\n.\tI-Disease\n05\tI-Disease\n)\tI-Disease\nand\tI-Disease\ncentral\tI-Disease\napnoea\tI-Disease\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\noccurred\tO\nmore\tO\nfrequently\tO\nin\tO\npatients\tO\nwho\tO\nhad\tO\na\tO\nmorphine\tB-Chemical\ninfusion\tO\n.\tO\n\nThere\tO\nwas\tO\nalso\tO\na\tO\nhigher\tO\nincidence\tO\nof\tO\ntachyarrhythmias\tB-Disease\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nventricular\tB-Disease\nectopic\tI-Disease\nbeats\tI-Disease\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nin\tO\nthe\tO\nmorphine\tB-Chemical\ninfusion\tO\ngroup\tO\n.\tO\n\nEffects\tO\nof\tO\naminophylline\tB-Chemical\non\tO\nthe\tO\nthreshold\tO\nfor\tO\ninitiating\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nduring\tO\nrespiratory\tB-Disease\nfailure\tI-Disease\n.\tO\n\nCardiac\tB-Disease\narrhythmias\tI-Disease\nhave\tO\nfrequently\tO\nbeen\tO\nreported\tO\nin\tO\nassociation\tO\nwith\tO\nrespiratory\tB-Disease\nfailure\tI-Disease\n.\tO\n\nThe\tO\npossible\tO\nadditive\tO\nrole\tO\nof\tO\npharmacologic\tO\nagents\tO\nin\tO\nprecipitating\tO\ncardiac\tB-Disease\ndisturbances\tI-Disease\nin\tO\npatients\tO\nwith\tO\nrespiratory\tB-Disease\nfailure\tI-Disease\nhas\tO\nonly\tO\nrecently\tO\nbeen\tO\nemphasized\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\naminophylline\tB-Chemical\non\tO\nthe\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nthreshold\tO\nduring\tO\nnormal\tO\nacid\tO\n-\tO\nbase\tO\nconditions\tO\nand\tO\nduring\tO\nrespiratory\tB-Disease\nfailure\tI-Disease\nwere\tO\nstudied\tO\nin\tO\nanesthetized\tO\nopen\tO\nchest\tO\ndogs\tO\n.\tO\n\nThe\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nthreshold\tO\nwas\tO\nmeasured\tO\nby\tO\npassing\tO\na\tO\ngated\tO\ntrain\tO\nof\tO\n12\tO\nconstant\tO\ncurrent\tO\npulses\tO\nthrough\tO\nthe\tO\nventricular\tO\nmyocardium\tO\nduring\tO\nthe\tO\nvulnerable\tO\nperiod\tO\nof\tO\nthe\tO\ncardiac\tO\ncycle\tO\n.\tO\n\nDuring\tO\nthe\tO\ninfusion\tO\nof\tO\naminophylline\tB-Chemical\n,\tO\nthe\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nthreshold\tO\nwas\tO\nreduced\tO\nby\tO\n30\tO\nto\tO\n40\tO\npercent\tO\nof\tO\nthe\tO\ncontrol\tO\nwhen\tO\npH\tO\nand\tO\npartial\tO\npressures\tO\nof\tO\noxygen\tB-Chemical\n(\tO\nPO2\tB-Chemical\n)\tO\nand\tO\ncarbon\tB-Chemical\ndioxide\tI-Chemical\n(\tO\nCO2\tB-Chemical\n)\tO\nwere\tO\nkept\tO\nwithin\tO\nnormal\tO\nlimits\tO\n.\tO\n\nWhen\tO\nrespiratory\tB-Disease\nfailure\tI-Disease\nwas\tO\nproduced\tO\nby\tO\nhypoventilation\tB-Disease\n(\tO\npH\tO\n7\tO\n.\tO\n05\tO\nto\tO\n7\tO\n.\tO\n25\tO\n;\tO\nPC02\tO\n70\tO\nto\tO\n100\tO\nmm\tO\nHg\tO\n:\tO\nP02\tO\n20\tO\nto\tO\n40\tO\nmm\tO\nHg\tO\n)\tO\n,\tO\ninfusion\tO\nof\tO\naminophylline\tB-Chemical\nresulted\tO\nin\tO\nan\tO\neven\tO\ngreater\tO\ndecrease\tO\nin\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nthreshold\tO\nto\tO\n60\tO\npercent\tO\nof\tO\nthe\tO\ncontrol\tO\nlevel\tO\n.\tO\n\nThese\tO\nexperiments\tO\nsuggest\tO\nthat\tO\nalthough\tO\nmany\tO\nfactors\tO\nmay\tO\ncontribute\tO\nto\tO\nthe\tO\nincreased\tO\nincidence\tO\nof\tO\nventricular\tB-Disease\narrhythmias\tI-Disease\nin\tO\nrespiratory\tB-Disease\nfailure\tI-Disease\n,\tO\npharmacologic\tO\nagents\tO\n,\tO\nparticularly\tO\naminophylline\tB-Chemical\n,\tO\nmay\tO\nplay\tO\na\tO\nsignificant\tO\nrole\tO\n.\tO\n\nPentoxifylline\tB-Chemical\n(\tO\nTrental\tB-Chemical\n)\tO\ndoes\tO\nnot\tO\ninhibit\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\ncoronary\tO\nhyperemia\tB-Disease\n:\tO\nimplications\tO\nfor\tO\ndipyridamole\tB-Chemical\n-\tO\nthallium\tB-Chemical\n-\tO\n201\tO\nmyocardial\tO\nimaging\tO\n.\tO\n\nDipyridamole\tB-Chemical\n-\tO\nthallium\tB-Chemical\n-\tO\n201\tO\nimaging\tO\nis\tO\noften\tO\nperformed\tO\nin\tO\npatients\tO\nunable\tO\nto\tO\nexercise\tO\nbecause\tO\nof\tO\nperipheral\tB-Disease\nvascular\tI-Disease\ndisease\tI-Disease\n.\tO\n\nMany\tO\nof\tO\nthese\tO\npatients\tO\nare\tO\ntaking\tO\npentoxifylline\tB-Chemical\n(\tO\nTrental\tB-Chemical\n)\tO\n,\tO\na\tO\nmethylxanthine\tB-Chemical\nderivative\tO\nwhich\tO\nmay\tO\nimprove\tO\nintermittent\tB-Disease\nclaudication\tI-Disease\n.\tO\n\nWhether\tO\npentoxifylline\tB-Chemical\ninhibits\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\ncoronary\tO\nhyperemia\tB-Disease\nlike\tO\nother\tO\nmethylxanthines\tB-Chemical\nsuch\tO\nas\tO\ntheophylline\tB-Chemical\nand\tO\nshould\tO\nbe\tO\nstopped\tO\nprior\tO\nto\tO\ndipyridamole\tB-Chemical\n-\tO\nthallium\tB-Chemical\n-\tO\n201\tO\nimaging\tO\nis\tO\nunknown\tO\n.\tO\n\nTherefore\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nhyperemic\tO\nresponse\tO\nto\tO\ndipyridamole\tB-Chemical\nin\tO\nseven\tO\nopen\tO\n-\tO\nchest\tO\nanesthetized\tO\ndogs\tO\nafter\tO\npretreatment\tO\nwith\tO\neither\tO\npentoxifylline\tB-Chemical\n(\tO\n0\tO\n,\tO\n7\tO\n.\tO\n5\tO\n,\tO\nor\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nor\tO\ntheophylline\tB-Chemical\n(\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\n.\tO\n\nBaseline\tO\ncircumflex\tO\ncoronary\tO\nblood\tO\nflows\tO\ndid\tO\nnot\tO\ndiffer\tO\nsignificantly\tO\namong\tO\ntreatment\tO\ngroups\tO\n.\tO\n\nDipyridamole\tB-Chemical\nsignificantly\tO\nincreased\tO\ncoronary\tO\nblood\tO\nflow\tO\nbefore\tO\nand\tO\nafter\tO\n7\tO\n.\tO\n5\tO\nor\tO\n15\tO\nmm\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\npentoxifylline\tB-Chemical\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nNeither\tO\ndose\tO\nof\tO\npentoxifylline\tB-Chemical\nsignificantly\tO\ndecreased\tO\nthe\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\nhyperemia\tB-Disease\n,\tO\nwhile\tO\npeak\tO\ncoronary\tO\nblood\tO\nflow\tO\nwas\tO\nsignificantly\tO\nlower\tO\nafter\tO\ntheophylline\tB-Chemical\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\npentoxyifylline\tB-Chemical\ndoes\tO\nnot\tO\ninhibit\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\ncoronary\tO\nhyperemia\tB-Disease\neven\tO\nat\tO\nhigh\tO\ndoses\tO\n.\tO\n\nCause\tO\nof\tO\ndeath\tB-Disease\namong\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n:\tO\na\tO\nrare\tO\nmortality\tO\ndue\tO\nto\tO\ncerebral\tB-Disease\nhaemorrhage\tI-Disease\n.\tO\n\nCauses\tO\nof\tO\ndeath\tB-Disease\n,\tO\nwith\tO\nspecial\tO\nreference\tO\nto\tO\ncerebral\tB-Disease\nhaemorrhage\tI-Disease\n,\tO\namong\tO\n240\tO\npatients\tO\nwith\tO\npathologically\tO\nverified\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nwere\tO\ninvestigated\tO\nusing\tO\nthe\tO\nAnnuals\tO\nof\tO\nthe\tO\nPathological\tO\nAutopsy\tO\nCases\tO\nin\tO\nJapan\tO\nfrom\tO\n1981\tO\nto\tO\n1985\tO\n.\tO\n\nThe\tO\nleading\tO\ncauses\tO\nof\tO\ndeath\tB-Disease\nwere\tO\npneumonia\tB-Disease\nand\tO\nbronchitis\tB-Disease\n(\tO\n44\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nmalignant\tO\nneoplasms\tB-Disease\n(\tO\n11\tO\n.\tO\n6\tO\n%\tO\n)\tO\n,\tO\nheart\tB-Disease\ndiseases\tI-Disease\n(\tO\n4\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\ncerebral\tB-Disease\ninfarction\tI-Disease\n(\tO\n3\tO\n.\tO\n7\tO\n%\tO\n)\tO\nand\tO\nsepticaemia\tB-Disease\n(\tO\n3\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nCerebral\tB-Disease\nhaemorrhage\tI-Disease\nwas\tO\nthe\tO\n11th\tO\nmost\tO\nfrequent\tO\ncause\tO\nof\tO\ndeath\tB-Disease\n,\tO\naccounting\tO\nfor\tO\nonly\tO\n0\tO\n.\tO\n8\tO\n%\tO\nof\tO\ndeaths\tB-Disease\namong\tO\nthe\tO\npatients\tO\n,\tO\nwhereas\tO\nit\tO\nwas\tO\nthe\tO\n5th\tO\nmost\tO\ncommon\tO\ncause\tO\nof\tO\ndeath\tB-Disease\namong\tO\nthe\tO\nJapanese\tO\ngeneral\tO\npopulation\tO\nin\tO\n1985\tO\n.\tO\n\nThe\tO\nlow\tO\nincidence\tO\nof\tO\ncerebral\tB-Disease\nhaemorrhage\tI-Disease\nas\tO\na\tO\ncause\tO\nof\tO\ndeath\tB-Disease\nin\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nmay\tO\nreflect\tO\nthe\tO\nhypotensive\tB-Disease\neffect\tO\nof\tO\nlevodopa\tB-Chemical\nand\tO\na\tO\nhypotensive\tB-Disease\nmechanism\tO\ndue\tO\nto\tO\nreduced\tO\nnoradrenaline\tB-Chemical\nlevels\tO\nin\tO\nthe\tO\nparkinsonian\tB-Disease\nbrain\tO\n.\tO\n\nPossible\tO\nintramuscular\tO\nmidazolam\tB-Chemical\n-\tO\nassociated\tO\ncardiorespiratory\tB-Disease\narrest\tI-Disease\nand\tO\ndeath\tB-Disease\n.\tO\n\nMidazolam\tB-Chemical\nhydrochloride\tI-Chemical\nis\tO\ncommonly\tO\nused\tO\nfor\tO\ndental\tO\nor\tO\nendoscopic\tO\nprocedures\tO\n.\tO\n\nAlthough\tO\ngenerally\tO\nconsisted\tO\nsafe\tO\nwhen\tO\ngiven\tO\nintramuscularly\tO\n,\tO\nintravenous\tO\nadministration\tO\nis\tO\nknown\tO\nto\tO\ncause\tO\nrespiratory\tB-Disease\nand\tI-Disease\ncardiovascular\tI-Disease\ndepression\tI-Disease\n.\tO\n\nThis\tO\nreport\tO\ndescribes\tO\nthe\tO\nfirst\tO\npublished\tO\ncase\tO\nof\tO\ncardiorespiratory\tB-Disease\narrest\tI-Disease\nand\tO\ndeath\tB-Disease\nassociated\tO\nwith\tO\nintramuscular\tO\nadministration\tO\nof\tO\nmidazolam\tB-Chemical\n.\tO\n\nInformation\tO\nregarding\tO\nmidazolam\tB-Chemical\nuse\tO\nis\tO\nreviewed\tO\nto\tO\nprovide\tO\nrecommendation\tO\nfor\tO\nsafe\tO\nadministration\tO\n.\tO\n\nMyasthenia\tB-Disease\ngravis\tI-Disease\npresenting\tO\nas\tO\nweakness\tO\nafter\tO\nmagnesium\tB-Chemical\nadministration\tO\n.\tO\n\nWe\tO\nstudied\tO\na\tO\npatient\tO\nwith\tO\nno\tO\nprior\tO\nhistory\tO\nof\tO\nneuromuscular\tB-Disease\ndisease\tI-Disease\nwho\tO\nbecame\tO\nvirtually\tO\nquadriplegic\tB-Disease\nafter\tO\nparenteral\tO\nmagnesium\tB-Chemical\nadministration\tO\nfor\tO\npreeclampsia\tB-Disease\n.\tO\n\nThe\tO\nserum\tO\nmagnesium\tB-Chemical\nconcentration\tO\nwas\tO\n3\tO\n.\tO\n0\tO\nmEq\tO\n/\tO\nL\tO\n,\tO\nwhich\tO\nis\tO\nusually\tO\nwell\tO\ntolerated\tO\n.\tO\n\nThe\tO\nmagnesium\tB-Chemical\nwas\tO\nstopped\tO\nand\tO\nshe\tO\nrecovered\tO\nover\tO\na\tO\nfew\tO\ndays\tO\n.\tO\n\nWhile\tO\nshe\tO\nwas\tO\nweak\tO\n,\tO\n2\tO\n-\tO\nHz\tO\nrepetitive\tO\nstimulation\tO\nrevealed\tO\na\tO\ndecrement\tO\nwithout\tO\nsignificant\tO\nfacilitation\tO\nat\tO\nrapid\tO\nrates\tO\nor\tO\nafter\tO\nexercise\tO\n,\tO\nsuggesting\tO\npostsynaptic\tB-Disease\nneuromuscular\tI-Disease\nblockade\tI-Disease\n.\tO\n\nAfter\tO\nher\tO\nstrength\tO\nreturned\tO\n,\tO\nrepetitive\tO\nstimulation\tO\nwas\tO\nnormal\tO\n,\tO\nbut\tO\nsingle\tO\nfiber\tO\nEMG\tO\nrevealed\tO\nincreased\tO\njitter\tO\nand\tO\nblocking\tO\n.\tO\n\nHer\tO\nacetylcholine\tB-Chemical\nreceptor\tO\nantibody\tO\nlevel\tO\nwas\tO\nmarkedly\tO\nelevated\tO\n.\tO\n\nAlthough\tO\nparalysis\tB-Disease\nafter\tO\nmagnesium\tB-Chemical\nadministration\tO\nhas\tO\nbeen\tO\ndescribed\tO\nin\tO\npatients\tO\nwith\tO\nknown\tO\nmyasthenia\tB-Disease\ngravis\tI-Disease\n,\tO\nit\tO\nhas\tO\nnot\tO\npreviously\tO\nbeen\tO\nreported\tO\nto\tO\nbe\tO\nthe\tO\ninitial\tO\nor\tO\nonly\tO\nmanifestation\tO\nof\tO\nthe\tO\ndisease\tO\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\nunusually\tO\nsensitive\tO\nto\tO\nthe\tO\nneuromuscular\tO\neffects\tO\nof\tO\nmagnesium\tB-Chemical\nshould\tO\nbe\tO\nsuspected\tO\nof\tO\nhaving\tO\nan\tO\nunderlying\tO\ndisorder\tB-Disease\nof\tI-Disease\nneuromuscular\tI-Disease\ntransmission\tI-Disease\n.\tO\n\nNo\tO\nenhancement\tO\nby\tO\nphenobarbital\tB-Chemical\nof\tO\nthe\tO\nhepatocarcinogenicity\tO\nof\tO\na\tO\ncholine\tB-Chemical\n-\tO\ndevoid\tO\ndiet\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nAn\tO\nexperiment\tO\nwas\tO\nperformed\tO\nto\tO\ntest\tO\nwhether\tO\ninclusion\tO\nof\tO\nphenobarbital\tB-Chemical\nin\tO\na\tO\ncholine\tB-Chemical\n-\tO\ndevoid\tO\ndiet\tO\nwould\tO\nincrease\tO\nthe\tO\nhepatocarcinogenicity\tO\nof\tO\nthe\tO\ndiet\tO\n.\tO\n\nGroups\tO\nof\tO\n5\tO\n-\tO\nweek\tO\nold\tO\nmale\tO\nFischer\tO\n-\tO\n344\tO\nrats\tO\nwere\tO\nfed\tO\nfor\tO\n7\tO\n-\tO\n25\tO\nmonths\tO\nsemipurified\tO\ncholine\tB-Chemical\n-\tO\ndevoid\tO\nor\tO\ncholine\tB-Chemical\n-\tO\nsupplemented\tO\ndiets\tO\n,\tO\ncontaining\tO\nor\tO\nnot\tO\n0\tO\n.\tO\n06\tO\n%\tO\nphenobarbital\tB-Chemical\n.\tO\n\nNo\tO\nhepatic\tO\npreneoplastic\tO\nnodules\tO\nor\tO\nhepatocellular\tB-Disease\ncarcinomas\tI-Disease\ndeveloped\tO\nin\tO\nrats\tO\nfed\tO\nthe\tO\nplain\tO\ncholine\tB-Chemical\n-\tO\nsupplemented\tO\ndiet\tO\n,\tO\nwhile\tO\none\tO\npreneoplastic\tO\nnodule\tO\nand\tO\none\tO\nhepatocellular\tB-Disease\ncarcinoma\tI-Disease\ndeveloped\tO\nin\tO\ntwo\tO\nrats\tO\nfed\tO\nthe\tO\nsame\tO\ndiet\tO\ncontaining\tO\nphenobarbital\tB-Chemical\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\npreneoplastic\tO\nnodules\tO\nand\tO\nof\tO\nhepatocellular\tB-Disease\ncarcinomas\tI-Disease\nwas\tO\n10\tO\n%\tO\nand\tO\n37\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\nfed\tO\nthe\tO\nplain\tO\ncholine\tB-Chemical\n-\tO\ndevoid\tO\ndiet\tO\n,\tO\nand\tO\n17\tO\n%\tO\nand\tO\n30\tO\n%\tO\n,\tO\nin\tO\nrats\tO\nfed\tO\nthe\tO\nphenobarbital\tB-Chemical\n-\tO\ncontaining\tO\ncholine\tB-Chemical\n-\tO\ndevoid\tO\ndiet\tO\n.\tO\n\nThe\tO\nresults\tO\nevinced\tO\nno\tO\nenhancement\tO\nof\tO\nthe\tO\nhepatocarcinogenicity\tO\nof\tO\nthe\tO\ncholine\tB-Chemical\n-\tO\ndevoid\tO\ndiet\tO\nby\tO\nphenobarbital\tB-Chemical\n.\tO\n\nSporadic\tO\nneoplastic\tO\nlesions\tO\nwere\tO\nobserved\tO\nin\tO\norgans\tO\nother\tO\nthan\tO\nthe\tO\nliver\tO\nof\tO\nsome\tO\nof\tO\nthe\tO\nanimals\tO\n,\tO\nirrespective\tO\nof\tO\nthe\tO\ndiet\tO\nfed\tO\n.\tO\n\nOn\tO\ntwo\tO\nparadoxical\tO\nside\tO\n-\tO\neffects\tO\nof\tO\nprednisolone\tB-Chemical\nin\tO\nrats\tO\n,\tO\nribosomal\tO\nRNA\tO\nbiosyntheses\tO\n,\tO\nand\tO\na\tO\nmechanism\tO\nof\tO\naction\tO\n.\tO\n\nLiver\tB-Disease\nenlargement\tI-Disease\nand\tO\nmuscle\tB-Disease\nwastage\tI-Disease\noccurred\tO\nin\tO\nWistar\tO\nrats\tO\nfollowing\tO\nthe\tO\nsubcutaneous\tO\nadministration\tO\nof\tO\nprednisolone\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\nliver\tO\nboth\tO\nthe\tO\ncontent\tO\nof\tO\nRNA\tO\nand\tO\nthe\tO\nbiosynthesis\tO\nof\tO\nribosomal\tO\nRNA\tO\nincreased\tO\nwhile\tO\nboth\tO\nthe\tO\nRNA\tO\ncontent\tO\nand\tO\nribosomal\tO\nRNA\tO\nbiosynthesis\tO\nwere\tO\nreduced\tO\nin\tO\nthe\tO\ngastrocnemius\tO\nmuscle\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\nthe\tO\ndrug\tO\nacted\tO\nin\tO\na\tO\nselective\tO\nand\tO\ntissue\tO\n-\tO\nspecific\tO\nmanner\tO\nto\tO\nenhance\tO\nribosomal\tO\nRNA\tO\nsynthesis\tO\nin\tO\nthe\tO\nliver\tO\nand\tO\ndepress\tO\nsuch\tO\nsynthesis\tO\nin\tO\nthe\tO\nmuscle\tO\n.\tO\n\nThis\tO\nview\tO\nsupports\tO\nthe\tO\ncontention\tO\nthat\tO\nthe\tO\nliver\tO\nand\tO\nmuscle\tO\nare\tO\nindependent\tO\nsites\tO\nof\tO\nprednisolone\tB-Chemical\naction\tO\n.\tO\n\nDifferential\tO\neffects\tO\nof\tO\ngamma\tB-Chemical\n-\tI-Chemical\nhexachlorocyclohexane\tI-Chemical\n(\tO\nlindane\tB-Chemical\n)\tO\non\tO\npharmacologically\tO\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nGamma\tB-Chemical\n-\tI-Chemical\nhexachlorocyclohexane\tI-Chemical\n(\tO\ngamma\tB-Chemical\n-\tI-Chemical\nHCH\tI-Chemical\n)\tO\n,\tO\nthe\tO\nactive\tO\ningredient\tO\nof\tO\nthe\tO\ninsecticide\tO\nlindane\tB-Chemical\n,\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\ndecrease\tO\nseizure\tB-Disease\nthreshold\tO\nto\tO\npentylenetrazol\tO\n(\tO\nPTZ\tB-Chemical\n)\tO\n3\tO\nh\tO\nafter\tO\nexposure\tO\nto\tO\ngamma\tB-Chemical\n-\tI-Chemical\nHCH\tI-Chemical\nand\tO\nconversely\tO\nincrease\tO\nthreshold\tO\nto\tO\nPTZ\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n24\tO\nh\tO\nafter\tO\nexposure\tO\nto\tO\ngamma\tB-Chemical\n-\tI-Chemical\nHCH\tI-Chemical\n(\tO\nVohland\tO\net\tO\nal\tO\n.\tO\n1981\tO\n)\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nthe\tO\nseverity\tO\nof\tO\nresponse\tO\nto\tO\nother\tO\nseizure\tB-Disease\n-\tO\ninducing\tO\nagents\tO\nwas\tO\ntested\tO\nin\tO\nmice\tO\n1\tO\nand\tO\n24\tO\nh\tO\nafter\tO\nintraperitoneal\tO\nadministration\tO\nof\tO\n80\tO\nmg\tO\n/\tO\nkg\tO\ngamma\tB-Chemical\n-\tI-Chemical\nHCH\tI-Chemical\n.\tO\n\nOne\tO\nhour\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\ngamma\tB-Chemical\n-\tI-Chemical\nHCH\tI-Chemical\n,\tO\nthe\tO\nactivity\tO\nof\tO\nseizure\tB-Disease\n-\tO\ninducing\tO\nagents\tO\nwas\tO\nincreased\tO\n,\tO\nregardless\tO\nof\tO\ntheir\tO\nmechanism\tO\n,\tO\nwhile\tO\n24\tO\nh\tO\nafter\tO\ngamma\tB-Chemical\n-\tI-Chemical\nHCH\tI-Chemical\na\tO\ndifferential\tO\nresponse\tO\nwas\tO\nobserved\tO\n.\tO\n\nSeizure\tB-Disease\nactivity\tO\ndue\tO\nto\tO\nPTZ\tB-Chemical\nand\tO\npicrotoxin\tB-Chemical\n(\tO\nPTX\tB-Chemical\n)\tO\nwas\tO\nsignificantly\tO\ndecreased\tO\n;\tO\nhowever\tO\n,\tO\nseizure\tB-Disease\nactivity\tO\ndue\tO\nto\tO\n3\tB-Chemical\n-\tI-Chemical\nmercaptopropionic\tI-Chemical\nacid\tI-Chemical\n(\tO\nMPA\tB-Chemical\n)\tO\n,\tO\nbicuculline\tB-Chemical\n(\tO\nBCC\tB-Chemical\n)\tO\n,\tO\nmethyl\tB-Chemical\n6\tI-Chemical\n,\tI-Chemical\n7\tI-Chemical\n-\tI-Chemical\ndimethoxy\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nethyl\tI-Chemical\n-\tI-Chemical\nB\tI-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\ncarboxylate\tI-Chemical\n(\tO\nDMCM\tB-Chemical\n)\tO\n,\tO\nor\tO\nstrychnine\tB-Chemical\n(\tO\nSTR\tB-Chemical\n)\tO\nwas\tO\nnot\tO\ndifferent\tO\nfrom\tO\ncontrol\tO\n.\tO\n\nIn\tO\nvitro\tO\n,\tO\ngamma\tB-Chemical\n-\tI-Chemical\nHCH\tI-Chemical\n,\tO\npentylenetetrazol\tB-Chemical\nand\tO\npicrotoxin\tB-Chemical\nwere\tO\nshown\tO\nto\tO\ninhibit\tO\n3H\tB-Chemical\n-\tI-Chemical\nTBOB\tI-Chemical\nbinding\tO\nin\tO\nmouse\tO\nwhole\tO\nbrain\tO\n,\tO\nwith\tO\nIC50\tO\nvalues\tO\nof\tO\n4\tO\n.\tO\n6\tO\n,\tO\n404\tO\nand\tO\n9\tO\n.\tO\n4\tO\nmicroM\tO\n,\tO\nrespectively\tO\n.\tO\n\nMPA\tB-Chemical\n,\tO\nBCC\tB-Chemical\n,\tO\nDMCM\tB-Chemical\n,\tO\nand\tO\nSTR\tB-Chemical\nshowed\tO\nno\tO\ninhibition\tO\nof\tO\n3H\tB-Chemical\n-\tI-Chemical\nTBOB\tI-Chemical\n(\tO\nt\tB-Chemical\n-\tI-Chemical\nbutyl\tI-Chemical\nbicyclo\tI-Chemical\n-\tI-Chemical\northobenzoate\tI-Chemical\n)\tO\nbinding\tO\nat\tO\nconcentrations\tO\nof\tO\n100\tO\nmicron\tO\n.\tO\n\nThe\tO\npharmacological\tO\nchallenge\tO\ndata\tO\nsuggest\tO\nthat\tO\ntolerance\tO\nmay\tO\noccur\tO\nto\tO\nseizure\tB-Disease\nactivity\tO\ninduced\tO\nby\tO\nPTZ\tB-Chemical\nand\tO\nPTX\tB-Chemical\n24\tO\nh\tO\nafter\tO\ngamma\tB-Chemical\n-\tI-Chemical\nHCH\tI-Chemical\n,\tO\nsince\tO\nthe\tO\nresponse\tO\nto\tO\nonly\tO\nthese\tO\ntwo\tO\nseizure\tB-Disease\n-\tO\ninducing\tO\nagents\tO\nis\tO\ndecreased\tO\n.\tO\n\nThe\tO\nin\tO\nvitro\tO\ndata\tO\nsuggest\tO\nthat\tO\nthe\tO\nsite\tO\nresponsible\tO\nfor\tO\nthe\tO\ndecrease\tO\nin\tO\nseizure\tB-Disease\nactivity\tO\n24\tO\nh\tO\nafter\tO\ngamma\tB-Chemical\n-\tI-Chemical\nHCH\tI-Chemical\nmay\tO\nbe\tO\nthe\tO\nGABA\tB-Chemical\n-\tO\nA\tO\nreceptor\tO\n-\tO\nlinked\tO\nchloride\tO\nchannel\tO\n.\tO\n\nTolerance\tO\nand\tO\nantiviral\tO\neffect\tO\nof\tO\nribavirin\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nArgentine\tB-Disease\nhemorrhagic\tI-Disease\nfever\tI-Disease\n.\tO\n\nTolerance\tO\nand\tO\nantiviral\tO\neffect\tO\nof\tO\nribavirin\tB-Chemical\nwas\tO\nstudied\tO\nin\tO\n6\tO\npatients\tO\nwith\tO\nArgentine\tB-Disease\nhemorrhagic\tI-Disease\nfever\tI-Disease\n(\tO\nAHF\tB-Disease\n)\tO\nof\tO\nmore\tO\nthan\tO\n8\tO\ndays\tO\nof\tO\nevolution\tO\n.\tO\n\nAdministration\tO\nof\tO\nribavirin\tB-Chemical\nresulted\tO\nin\tO\na\tO\nneutralization\tO\nof\tO\nviremia\tB-Disease\nand\tO\na\tO\ndrop\tO\nof\tO\nendogenous\tO\ninterferon\tO\ntiters\tO\n.\tO\n\nThe\tO\naverage\tO\ntime\tO\nof\tO\ndeath\tB-Disease\nwas\tO\ndelayed\tO\n.\tO\n\nA\tO\nreversible\tO\nanemia\tB-Disease\nwas\tO\nthe\tO\nonly\tO\nadverse\tO\neffect\tO\nobserved\tO\n.\tO\n\nFrom\tO\nthese\tO\nresults\tO\n,\tO\nwe\tO\nconclude\tO\nthat\tO\nribavirin\tB-Chemical\nhas\tO\nan\tO\nantiviral\tO\neffect\tO\nin\tO\nadvanced\tO\ncases\tO\nof\tO\nAHF\tB-Disease\n,\tO\nand\tO\nthat\tO\nanemia\tB-Disease\n,\tO\nthe\tO\nonly\tO\nsecondary\tO\nreaction\tO\nobserved\tO\n,\tO\ncan\tO\nbe\tO\neasily\tO\nmanaged\tO\n.\tO\n\nThe\tO\npossible\tO\nbeneficial\tO\neffect\tO\nof\tO\nribavirin\tB-Chemical\nduring\tO\nthe\tO\ninitial\tO\ndays\tO\nof\tO\nAHF\tB-Disease\nis\tO\ndiscussed\tO\n.\tO\n\nIs\tO\nthe\tO\ntreatment\tO\nof\tO\nscabies\tB-Disease\nhazardous\tO\n?\tO\n\nTreatment\tO\nfor\tO\nscabies\tB-Disease\nis\tO\nusually\tO\ninitiated\tO\nby\tO\ngeneral\tO\npractitioners\tO\n;\tO\nmost\tO\nconsider\tO\nlindane\tB-Chemical\n(\tO\ngamma\tB-Chemical\nbenzene\tI-Chemical\nhexachloride\tI-Chemical\n)\tO\nthe\tO\ntreatment\tO\nof\tO\nchoice\tO\n.\tO\n\nLindane\tB-Chemical\nis\tO\nalso\tO\nwidely\tO\nused\tO\nas\tO\nan\tO\nagricultural\tO\nand\tO\nindustrial\tO\npesticide\tO\n,\tO\nand\tO\nas\tO\na\tO\nresult\tO\nthe\tO\ntoxic\tO\nprofile\tO\nof\tO\nthis\tO\ninsecticide\tO\nis\tO\nwell\tO\nunderstood\tO\n.\tO\n\nEvidence\tO\nis\tO\naccumulating\tO\nthat\tO\nlindane\tB-Chemical\ncan\tO\nbe\tO\ntoxic\tB-Disease\nto\tI-Disease\nthe\tI-Disease\ncentral\tI-Disease\nnervous\tI-Disease\nsystem\tI-Disease\nand\tO\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\naplastic\tB-Disease\nanaemia\tI-Disease\n.\tO\n\nPreparations\tO\ncontaining\tO\nlindane\tB-Chemical\ncontinue\tO\nto\tO\nbe\tO\nsold\tO\nover\tO\nthe\tO\ncounter\tO\nand\tO\nmay\tO\nrepresent\tO\na\tO\nhazard\tO\nto\tO\npoorly\tO\ninformed\tO\npatients\tO\n.\tO\n\nThis\tO\nliterature\tO\nreview\tO\nsuggests\tO\nthat\tO\ngeneral\tO\npractitioners\tO\nshould\tO\nprescribe\tO\nscabicides\tO\nwith\tO\nincreased\tO\ncaution\tO\nfor\tO\ncertain\tO\nat\tO\n-\tO\nrisk\tO\ngroups\tO\n,\tO\nand\tO\ngive\tO\nadequate\tO\nwarnings\tO\nregarding\tO\npotential\tO\ntoxicity\tB-Disease\n.\tO\n\nMouse\tO\nstrain\tO\n-\tO\ndependent\tO\neffect\tO\nof\tO\namantadine\tB-Chemical\non\tO\nmotility\tO\nand\tO\nbrain\tO\nbiogenic\tO\namines\tB-Chemical\n.\tO\n\nThe\tO\neffect\tO\nof\tO\namantadine\tB-Chemical\nhydrochloride\tI-Chemical\n,\tO\ninjected\tO\ni\tO\n.\tO\np\tO\n.\tO\nin\tO\n6\tO\nincrements\tO\nof\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\neach\tO\nover\tO\n30\tO\nhr\tO\n,\tO\non\tO\nmouse\tO\nmotility\tO\nand\tO\nwhole\tO\nbrain\tO\ncontent\tO\nof\tO\nselected\tO\nbiogenic\tO\namines\tB-Chemical\nand\tO\nmajor\tO\nmetabolites\tO\nwas\tO\nstudied\tO\nin\tO\n4\tO\nstrains\tO\nof\tO\nmice\tO\n.\tO\n\nThese\tO\nwere\tO\nthe\tO\nalbino\tO\nSprague\tO\n-\tO\nDawley\tO\nICR\tO\nand\tO\nBALB\tO\n/\tO\nC\tO\n,\tO\nthe\tO\nblack\tO\nC57BL\tO\n/\tO\n6\tO\nand\tO\nthe\tO\nbrown\tO\nCDF\tO\n-\tO\nI\tO\nmouse\tO\nstrains\tO\n.\tO\n\nAmantadine\tB-Chemical\ntreatment\tO\nproduced\tO\na\tO\nbiphasic\tO\neffect\tO\non\tO\nmouse\tO\nmotility\tO\n.\tO\n\nThe\tO\ninitial\tO\ndose\tO\nof\tO\namantadine\tB-Chemical\ndepressed\tB-Disease\nlocomotor\tO\nactivity\tO\nin\tO\nall\tO\nmouse\tO\nstrains\tO\nstudied\tO\nwith\tO\nthe\tO\nBALB\tO\n/\tO\nC\tO\nmice\tO\nbeing\tO\nthe\tO\nmost\tO\nsensitive\tO\n.\tO\n\nSubsequent\tO\namantadine\tB-Chemical\ntreatments\tO\nproduced\tO\nenhancement\tO\nof\tO\nmotility\tO\nfrom\tO\ncorresponding\tO\ncontrol\tO\nin\tO\nall\tO\nmouse\tO\nstrains\tO\nwith\tO\nthe\tO\nBALB\tO\n/\tO\nC\tO\nmice\tO\nbeing\tO\nthe\tO\nleast\tO\nsensitive\tO\n.\tO\n\nThe\tO\nlocomotor\tO\nactivity\tO\nwas\tO\ndecreased\tO\nfrom\tO\ncorresponding\tO\ncontrols\tO\nin\tO\nall\tO\nstrains\tO\nstudied\tO\n,\tO\nexcept\tO\nfor\tO\nthe\tO\nICR\tO\nmice\tO\n,\tO\nduring\tO\nan\tO\novernight\tO\ndrug\tO\n-\tO\nfree\tO\nperiod\tO\nfollowing\tO\nthe\tO\nfourth\tO\namantadine\tB-Chemical\ntreatment\tO\n.\tO\n\nReadministration\tO\nof\tO\namantadine\tB-Chemical\n,\tO\nafter\tO\na\tO\ndrug\tO\n-\tO\nfree\tO\novernight\tO\nperiod\tO\n,\tO\nincreased\tO\nmotility\tO\nfrom\tO\nrespective\tO\nsaline\tO\ncontrol\tO\nin\tO\nall\tO\nstrains\tO\nwith\tO\nexception\tO\nof\tO\nthe\tO\nBALB\tO\n/\tO\nC\tO\nmice\tO\nwhere\tO\nsuppression\tB-Disease\nof\tI-Disease\nmotility\tI-Disease\noccurred\tO\n.\tO\n\nTreatment\tO\nwith\tO\namantadine\tB-Chemical\ndid\tO\nnot\tO\nalter\tO\nwhole\tO\nbrain\tO\ndopamine\tB-Chemical\nlevels\tO\nbut\tO\ndecreased\tO\nthe\tO\namounts\tO\nof\tO\n3\tB-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndihydroxyphenylacetic\tI-Chemical\nacid\tI-Chemical\nin\tO\nthe\tO\nBALB\tO\n/\tO\nC\tO\nmice\tO\ncompared\tO\nto\tO\nsaline\tO\ncontrol\tO\n.\tO\n\nConversely\tO\n,\tO\nbrain\tO\nnormetanephrine\tB-Chemical\nconcentration\tO\nwas\tO\nincreased\tO\nfrom\tO\nsaline\tO\ncontrol\tO\nby\tO\namantadine\tB-Chemical\nin\tO\nthe\tO\nBALB\tO\n/\tO\nC\tO\nmice\tO\n.\tO\n\nThe\tO\nresults\tO\nsuggest\tO\na\tO\nstrain\tO\n-\tO\ndependent\tO\neffect\tO\nof\tO\namantadine\tB-Chemical\non\tO\nmotility\tO\nand\tO\nindicate\tO\na\tO\ndifferential\tO\nresponse\tO\nto\tO\nthe\tO\nacute\tO\nand\tO\nmultiple\tO\ndose\tO\nregimens\tO\nused\tO\n.\tO\n\nThe\tO\nBALB\tO\n/\tO\nC\tO\nmouse\tO\nwas\tO\nthe\tO\nmost\tO\nsensitive\tO\nstrain\tO\nand\tO\ncould\tO\nserve\tO\nas\tO\nthe\tO\nstrain\tO\nof\tO\nchoice\tO\nfor\tO\nevaluating\tO\nthe\tO\nside\tO\neffects\tO\nof\tO\namantadine\tB-Chemical\n.\tO\n\nThe\tO\nbiochemical\tO\nresults\tO\nof\tO\nbrain\tO\nbiogenic\tO\namines\tB-Chemical\nof\tO\nBALB\tO\n/\tO\nC\tO\nmouse\tO\nstrain\tO\nsuggest\tO\na\tO\nprobable\tO\ndecrease\tO\nof\tO\ncatecholamine\tB-Chemical\nturnover\tO\nrate\tO\nand\tO\n/\tO\nor\tO\nmetabolism\tO\nby\tO\nmonoamine\tO\noxidase\tO\nand\tO\na\tO\nresulting\tO\nincrease\tO\nin\tO\nO\tO\n-\tO\nmethylation\tO\nof\tO\nnorepinephrine\tB-Chemical\nwhich\tO\nmay\tO\naccount\tO\nfor\tO\na\tO\nbehavioral\tB-Disease\ndepression\tI-Disease\ncaused\tO\nby\tO\namantadine\tB-Chemical\nin\tO\nthe\tO\nBALB\tO\n/\tO\nC\tO\nmice\tO\n.\tO\n\nChloroacetaldehyde\tB-Chemical\nand\tO\nits\tO\ncontribution\tO\nto\tO\nurotoxicity\tO\nduring\tO\ntreatment\tO\nwith\tO\ncyclophosphamide\tB-Chemical\nor\tO\nifosfamide\tB-Chemical\n.\tO\n\nAn\tO\nexperimental\tO\nstudy\tO\n/\tO\nshort\tO\ncommunication\tO\n.\tO\n\nBased\tO\non\tO\nclinical\tO\ndata\tO\n,\tO\nindicating\tO\nthat\tO\nchloroacetaldehyde\tB-Chemical\n(\tO\nCAA\tB-Chemical\n)\tO\nis\tO\nan\tO\nimportant\tO\nmetabolite\tO\nof\tO\noxazaphosphorine\tO\ncytostatics\tO\n,\tO\nan\tO\nexperimental\tO\nstudy\tO\nwas\tO\ncarried\tO\nout\tO\nin\tO\norder\tO\nto\tO\nelucidate\tO\nthe\tO\nrole\tO\nof\tO\nCAA\tB-Chemical\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nThe\tO\ndata\tO\ndemonstrate\tO\nthat\tO\nCAA\tB-Chemical\nafter\tO\ni\tO\n.\tO\nv\tO\n.\tO\nadministration\tO\ndoes\tO\nnot\tO\ncontribute\tO\nto\tO\nbladder\tB-Disease\ndamage\tI-Disease\n.\tO\n\nWhen\tO\ninstilled\tO\ndirectly\tO\ninto\tO\nthe\tO\nbladder\tO\n,\tO\nCAA\tB-Chemical\nexerts\tO\nurotoxic\tO\neffects\tO\n,\tO\nit\tO\nis\tO\n,\tO\nhowever\tO\n,\tO\nsusceptible\tO\nto\tO\ndetoxification\tO\nwith\tO\nmesna\tB-Chemical\n.\tO\n\nSource\tO\nof\tO\npain\tB-Disease\nand\tO\nprimitive\tO\ndysfunction\tO\nin\tO\nmigraine\tB-Disease\n:\tO\nan\tO\nidentical\tO\nsite\tO\n?\tO\n\nTwenty\tO\ncommon\tO\nmigraine\tB-Disease\npatients\tO\nreceived\tO\na\tO\none\tO\nsided\tO\nfrontotemporal\tO\napplication\tO\nof\tO\nnitroglycerin\tB-Chemical\n(\tO\n10\tO\npatients\tO\n)\tO\nor\tO\nplacebo\tO\nointment\tO\n(\tO\n10\tO\npatients\tO\n)\tO\nin\tO\na\tO\ndouble\tO\nblind\tO\nstudy\tO\n.\tO\n\nEarly\tO\nonset\tO\nmigraine\tB-Disease\nattacks\tO\nwere\tO\ninduced\tO\nby\tO\nnitroglycerin\tB-Chemical\nin\tO\nseven\tO\nout\tO\nof\tO\n10\tO\npatients\tO\nversus\tO\nno\tO\npatient\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\n.\tO\n\nSubsequently\tO\n20\tO\nmigraine\tB-Disease\npatients\tO\n,\tO\nwho\tO\ndeveloped\tO\nan\tO\nearly\tO\nonset\tO\nattack\tO\nwith\tO\nfrontotemporal\tO\nnitroglycerin\tB-Chemical\n,\tO\nreceived\tO\nthe\tO\ndrug\tO\nin\tO\na\tO\nsecond\tO\ninduction\tO\ntest\tO\nat\tO\nother\tO\nbody\tO\nareas\tO\n.\tO\n\nNo\tO\nearly\tO\nonset\tO\nmigraine\tB-Disease\nwas\tO\nobserved\tO\n.\tO\n\nThus\tO\nthe\tO\nmigraine\tB-Disease\n-\tO\ninducing\tO\neffect\tO\nof\tO\nnitroglycerin\tB-Chemical\nseems\tO\nto\tO\ndepend\tO\non\tO\ndirect\tO\nstimulation\tO\nof\tO\nthe\tO\nhabitual\tO\nsite\tO\nof\tO\npain\tB-Disease\n,\tO\nsuggesting\tO\nthat\tO\nthe\tO\nfrontotemporal\tO\nregion\tO\nis\tO\nof\tO\ncrucial\tO\nimportance\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\na\tO\nmigraine\tB-Disease\ncrisis\tO\n.\tO\n\nThis\tO\nis\tO\nnot\tO\nconsistent\tO\nwith\tO\na\tO\nCNS\tO\norigin\tO\nof\tO\nmigraine\tB-Disease\nattack\tO\n.\tO\n\nHypersensitivity\tB-Disease\nto\tO\ncarbamazepine\tB-Chemical\npresenting\tO\nwith\tO\na\tO\nleukemoid\tB-Disease\nreaction\tI-Disease\n,\tO\neosinophilia\tB-Disease\n,\tO\nerythroderma\tB-Disease\n,\tO\nand\tO\nrenal\tB-Disease\nfailure\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\npatient\tO\nin\tO\nwhom\tO\nhypersensitivity\tB-Disease\nto\tO\ncarbamazepine\tB-Chemical\npresented\tO\nwith\tO\ngeneralized\tO\nerythroderma\tB-Disease\n,\tO\na\tO\nsevere\tO\nleukemoid\tB-Disease\nreaction\tI-Disease\n,\tO\neosinophilia\tB-Disease\n,\tO\nhyponatremia\tB-Disease\n,\tO\nand\tO\nrenal\tB-Disease\nfailure\tI-Disease\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nreport\tO\nof\tO\nsuch\tO\nan\tO\nunusual\tO\nreaction\tO\nto\tO\ncarbamazepine\tB-Chemical\n.\tO\n\nFluoxetine\tB-Chemical\n-\tO\ninduced\tO\nakathisia\tB-Disease\n:\tO\nclinical\tO\nand\tO\ntheoretical\tO\nimplications\tO\n.\tO\n\nFive\tO\npatients\tO\nreceiving\tO\nfluoxetine\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nobsessive\tB-Disease\ncompulsive\tI-Disease\ndisorder\tI-Disease\nor\tO\nmajor\tB-Disease\ndepression\tI-Disease\ndeveloped\tO\nakathisia\tB-Disease\n.\tO\n\nThe\tO\ntypical\tO\nfluoxetine\tB-Chemical\n-\tO\ninduced\tO\nsymptoms\tO\nof\tO\nrestlessness\tO\n,\tO\nconstant\tO\npacing\tO\n,\tO\npurposeless\tO\nmovements\tO\nof\tO\nthe\tO\nfeet\tO\nand\tO\nlegs\tO\n,\tO\nand\tO\nmarked\tO\nanxiety\tB-Disease\nwere\tO\nindistinguishable\tO\nfrom\tO\nthose\tO\nof\tO\nneuroleptic\tO\n-\tO\ninduced\tO\nakathisia\tB-Disease\n.\tO\n\nThree\tO\npatients\tO\nwho\tO\nhad\tO\nexperienced\tO\nneuroleptic\tO\n-\tO\ninduced\tO\nakathisia\tB-Disease\nin\tO\nthe\tO\npast\tO\nreported\tO\nthat\tO\nthe\tO\nsymptoms\tO\nof\tO\nfluoxetine\tB-Chemical\n-\tO\ninduced\tO\nakathisia\tB-Disease\nwere\tO\nidentical\tO\n,\tO\nalthough\tO\nsomewhat\tO\nmilder\tO\n.\tO\n\nAkathisia\tB-Disease\nappeared\tO\nto\tO\nbe\tO\na\tO\ncommon\tO\nside\tO\neffect\tO\nof\tO\nfluoxetine\tB-Chemical\nand\tO\ngenerally\tO\nresponded\tO\nwell\tO\nto\tO\ntreatment\tO\nwith\tO\nthe\tO\nbeta\tO\n-\tO\nadrenergic\tO\nantagonist\tO\npropranolol\tB-Chemical\n,\tO\ndose\tO\nreduction\tO\n,\tO\nor\tO\nboth\tO\n.\tO\n\nThe\tO\nauthors\tO\nsuggest\tO\nthat\tO\nfluoxetine\tB-Chemical\n-\tO\ninduced\tO\nakathisia\tB-Disease\nmay\tO\nbe\tO\ncaused\tO\nby\tO\nserotonergically\tO\nmediated\tO\ninhibition\tO\nof\tO\ndopaminergic\tO\nneurotransmission\tO\nand\tO\nthat\tO\nthe\tO\npathophysiology\tO\nof\tO\nfluoxetine\tB-Chemical\n-\tO\ninduced\tO\nakathisia\tB-Disease\nand\tO\ntricyclic\tO\nantidepressant\tB-Chemical\n-\tO\ninduced\tO\n\"\tO\njitteriness\tO\n\"\tO\nmay\tO\nbe\tO\nidentical\tO\n.\tO\n\nEffect\tO\nof\tO\nconverting\tO\nenzyme\tO\ninhibition\tO\non\tO\nthe\tO\ncourse\tO\nof\tO\nadriamycin\tB-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nthe\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\n(\tO\nCEI\tO\n)\tO\nenalapril\tB-Chemical\nwas\tO\nassessed\tO\nin\tO\nMunich\tO\n-\tO\nWistar\tO\nrats\tO\nwith\tO\nestablished\tO\nadriamycin\tB-Chemical\nnephrosis\tB-Disease\n.\tO\n\nRats\tO\nwere\tO\ngiven\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nadriamycin\tB-Chemical\nand\tO\none\tO\nmonth\tO\nlater\tO\ndivided\tO\ninto\tO\nfour\tO\ngroups\tO\nmatched\tO\nfor\tO\nalbuminuria\tB-Disease\n,\tO\nblood\tO\npressure\tO\n,\tO\nand\tO\nplasma\tO\nalbumin\tO\nconcentration\tO\n.\tO\n\nGroups\tO\n1\tO\nand\tO\n3\tO\nremained\tO\nuntreated\tO\nwhile\tO\ngroups\tO\n2\tO\nand\tO\n4\tO\nreceived\tO\nenalapril\tB-Chemical\n.\tO\n\nGroups\tO\n1\tO\nand\tO\n2\tO\nunderwent\tO\nmicropuncture\tO\nstudies\tO\nafter\tO\n10\tO\ndays\tO\n.\tO\n\nThese\tO\nshort\tO\n-\tO\nterm\tO\nstudies\tO\nshowed\tO\nthat\tO\nenalapril\tB-Chemical\nreduced\tO\narterial\tO\nblood\tO\npressure\tO\n(\tO\n101\tO\n+\tO\n/\tO\n-\tO\n2\tO\nvs\tO\n.\tO\n124\tO\n+\tO\n/\tO\n-\tO\n3\tO\nmm\tO\nHg\tO\n,\tO\ngroup\tO\n2\tO\nvs\tO\n.\tO\n1\tO\n,\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nglomerular\tO\ncapillary\tO\npressure\tO\n(\tO\n54\tO\n+\tO\n/\tO\n-\tO\n1\tO\nvs\tO\n.\tO\n61\tO\n+\tO\n/\tO\n-\tO\n2\tO\nmm\tO\nHg\tO\n,\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nwithout\tO\nreducing\tO\nalbuminuria\tB-Disease\n(\tO\n617\tO\n+\tO\n/\tO\n-\tO\n50\tO\nvs\tO\n.\tO\n570\tO\n+\tO\n/\tO\n-\tO\n47\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nor\tO\nGFR\tO\n(\tO\n1\tO\n.\tO\n03\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n04\tO\nvs\tO\n.\tO\n1\tO\n.\tO\n04\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n11\tO\nml\tO\n/\tO\nmin\tO\n)\tO\n.\tO\n\nGroups\tO\n3\tO\nand\tO\n4\tO\nwere\tO\nstudied\tO\nat\tO\nfour\tO\nand\tO\nat\tO\nsix\tO\nmonths\tO\nto\tO\nassess\tO\nthe\tO\neffect\tO\nof\tO\nenalapril\tB-Chemical\non\tO\nprogression\tO\nof\tO\nrenal\tB-Disease\ninjury\tI-Disease\nin\tO\nadriamycin\tB-Chemical\nnephrosis\tB-Disease\n.\tO\n\nChronic\tO\nenalapril\tB-Chemical\ntreatment\tO\nreduced\tO\nblood\tO\npressure\tO\nwithout\tO\nreducing\tO\nalbuminuria\tB-Disease\nin\tO\ngroup\tO\n4\tO\n.\tO\n\nUntreated\tO\ngroup\tO\n3\tO\nrats\tO\nexhibited\tO\na\tO\nprogressive\tO\nreduction\tO\nin\tO\nGFR\tO\n(\tO\n0\tO\n.\tO\n35\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n08\tO\nml\tO\n/\tO\nmin\tO\nat\tO\n4\tO\nmonths\tO\n,\tO\n0\tO\n.\tO\n27\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n07\tO\nml\tO\n/\tO\nmin\tO\nat\tO\n6\tO\nmonths\tO\n)\tO\n.\tO\n\nEnalapril\tB-Chemical\ntreatment\tO\nblunted\tO\nbut\tO\ndid\tO\nnot\tO\nprevent\tO\nreduction\tO\nin\tO\nGFR\tO\nin\tO\ngroup\tO\n4\tO\n(\tO\n0\tO\n.\tO\n86\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n15\tO\nml\tO\n/\tO\nmin\tO\nat\tO\n4\tO\nmonths\tO\n,\tO\n0\tO\n.\tO\n69\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n13\tO\nml\tO\n/\tO\nmin\tO\nat\tO\n6\tO\nmonths\tO\n,\tO\nboth\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\nvs\tO\n.\tO\ngroup\tO\n3\tO\n)\tO\n.\tO\n\nReduction\tO\nin\tO\nGFR\tO\nwas\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nglomerular\tB-Disease\nsclerosis\tI-Disease\nin\tO\nboth\tO\ntreated\tO\nand\tO\nuntreated\tO\nrats\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nClotiazepam\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\nhepatitis\tB-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\npatient\tO\nwho\tO\ndeveloped\tO\nacute\tO\nhepatitis\tB-Disease\nwith\tO\nextensive\tB-Disease\nhepatocellular\tI-Disease\nnecrosis\tI-Disease\n,\tO\n7\tO\nmonths\tO\nafter\tO\nthe\tO\nonset\tO\nof\tO\nadministration\tO\nof\tO\nclotiazepam\tB-Chemical\n,\tO\na\tO\nthienodiazepine\tB-Chemical\nderivative\tO\n.\tO\n\nClotiazepam\tB-Chemical\nwithdrawal\tO\nwas\tO\nfollowed\tO\nby\tO\nprompt\tO\nrecovery\tO\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nseveral\tO\nbenzodiazepines\tB-Chemical\n,\tO\nchemically\tO\nrelated\tO\nto\tO\nclotiazepam\tB-Chemical\n,\tO\ndid\tO\nnot\tO\ninterfere\tO\nwith\tO\nrecovery\tO\nand\tO\ndid\tO\nnot\tO\ninduce\tO\nany\tO\nrelapse\tO\nof\tO\nhepatitis\tB-Disease\n.\tO\n\nThis\tO\nobservation\tO\nshows\tO\nthat\tO\nclotiazepam\tB-Chemical\ncan\tO\ninduce\tO\nacute\tO\nhepatitis\tB-Disease\nand\tO\nsuggests\tO\nthat\tO\nthere\tO\nis\tO\nno\tO\ncross\tO\nhepatotoxicity\tB-Disease\nbetween\tO\nclotiazepam\tB-Chemical\nand\tO\nseveral\tO\nbenzodiazepines\tB-Chemical\n.\tO\n\n5\tB-Chemical\n-\tI-Chemical\nazacytidine\tI-Chemical\npotentiates\tO\ninitiation\tB-Disease\ninduced\tI-Disease\nby\tI-Disease\ncarcinogens\tI-Disease\nin\tO\nrat\tO\nliver\tO\n.\tO\n\nTo\tO\ntest\tO\nthe\tO\nvalidity\tO\nof\tO\nthe\tO\nhypothesis\tO\nthat\tO\nhypomethylation\tO\nof\tO\nDNA\tO\nplays\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\ninitiation\tB-Disease\nof\tI-Disease\ncarcinogenic\tI-Disease\nprocess\tI-Disease\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nazacytidine\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nAzC\tI-Chemical\n)\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nan\tO\ninhibitor\tO\nof\tO\nDNA\tO\nmethylation\tO\n,\tO\nwas\tO\ngiven\tO\nto\tO\nrats\tO\nduring\tO\nthe\tO\nphase\tO\nof\tO\nrepair\tO\nsynthesis\tO\ninduced\tO\nby\tO\nthe\tO\nthree\tO\ncarcinogens\tO\n,\tO\nbenzo\tB-Chemical\n[\tI-Chemical\na\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\npyrene\tI-Chemical\n(\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\nnitrosourea\tI-Chemical\n(\tO\n60\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\n1\tB-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ndimethylhydrazine\tI-Chemical\n(\tO\n1\tB-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nDMH\tI-Chemical\n)\tO\n(\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nThe\tO\ninitiated\tO\nhepatocytes\tO\nin\tO\nthe\tO\nliver\tO\nwere\tO\nassayed\tO\nas\tO\nthe\tO\ngamma\tO\n-\tO\nglutamyltransferase\tO\n(\tO\ngamma\tO\n-\tO\nGT\tO\n)\tO\npositive\tO\nfoci\tO\nformed\tO\nfollowing\tO\na\tO\n2\tO\n-\tO\nweek\tO\nselection\tO\nregimen\tO\nconsisting\tO\nof\tO\ndietary\tO\n0\tO\n.\tO\n02\tO\n%\tO\n2\tB-Chemical\n-\tI-Chemical\nacetylaminofluorene\tI-Chemical\ncoupled\tO\nwith\tO\na\tO\nnecrogenic\tO\ndose\tO\nof\tO\nCCl4\tB-Chemical\n.\tO\n\nThe\tO\nresults\tO\nobtained\tO\nindicate\tO\nthat\tO\nwith\tO\nall\tO\nthree\tO\ncarcinogens\tO\n,\tO\nadministration\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nAzC\tI-Chemical\nduring\tO\nrepair\tO\nsynthesis\tO\nincreased\tO\nthe\tO\nincidence\tO\nof\tO\ninitiated\tO\nhepatocytes\tO\n,\tO\nfor\tO\nexample\tO\n10\tO\n-\tO\n20\tO\nfoci\tO\n/\tO\ncm2\tO\nin\tO\n5\tB-Chemical\n-\tI-Chemical\nAzC\tI-Chemical\nand\tO\ncarcinogen\tO\n-\tO\ntreated\tO\nrats\tO\ncompared\tO\nwith\tO\n3\tO\n-\tO\n5\tO\nfoci\tO\n/\tO\ncm2\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncarcinogen\tO\nonly\tO\n.\tO\n\nAdministration\tO\nof\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\nazadeoxycytidine\tI-Chemical\nduring\tO\nthe\tO\nrepair\tO\nsynthesis\tO\ninduced\tO\nby\tO\n1\tB-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nDMH\tI-Chemical\nfurther\tO\nshowed\tO\nthat\tO\n0\tO\n.\tO\n019\tO\nmol\tO\n%\tO\nof\tO\ncytosine\tB-Chemical\nresidues\tO\nin\tO\nDNA\tO\nwere\tO\nsubstituted\tO\nby\tO\nthe\tO\nanalogue\tO\n,\tO\nindicating\tO\nthat\tO\nincorporation\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nAzC\tI-Chemical\noccurs\tO\nduring\tO\nrepair\tO\nsynthesis\tO\n.\tO\n\nIn\tO\nthe\tO\nabsence\tO\nof\tO\nthe\tO\ncarcinogen\tO\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nAzC\tI-Chemical\ngiven\tO\nafter\tO\na\tO\ntwo\tO\nthirds\tO\npartial\tO\nhepatectomy\tO\n,\tO\nwhen\tO\nits\tO\nincorporation\tO\nshould\tO\nbe\tO\nmaximum\tO\n,\tO\nfailed\tO\nto\tO\ninduce\tO\nany\tO\ngamma\tO\n-\tO\nGT\tO\npositive\tO\nfoci\tO\n.\tO\n\nThe\tO\nresults\tO\nsuggest\tO\nthat\tO\nhypomethylation\tO\nof\tO\nDNA\tO\nper\tO\nse\tO\nmay\tO\nnot\tO\nbe\tO\nsufficient\tO\nfor\tO\ninitiation\tO\n.\tO\n\nPerhaps\tO\ntwo\tO\nevents\tO\nmight\tO\nbe\tO\nnecessary\tO\nfor\tO\ninitiation\tO\n,\tO\nthe\tO\nfirst\tO\ncaused\tO\nby\tO\nthe\tO\ncarcinogen\tO\nand\tO\na\tO\nsecond\tO\ninvolving\tO\nhypomethylation\tO\nof\tO\nDNA\tO\n.\tO\n\nAntihypertensive\tO\ndrugs\tO\nand\tO\ndepression\tB-Disease\n:\tO\na\tO\nreappraisal\tO\n.\tO\n\nEighty\tO\n-\tO\nnine\tO\nnew\tO\nreferral\tO\nhypertensive\tB-Disease\nout\tO\n-\tO\npatients\tO\nand\tO\n46\tO\nnew\tO\nreferral\tO\nnon\tO\n-\tO\nhypertensive\tB-Disease\nchronically\tO\nphysically\tO\nill\tO\nout\tO\n-\tO\npatients\tO\ncompleted\tO\na\tO\nmood\tO\nrating\tO\nscale\tO\nat\tO\nregular\tO\nintervals\tO\nfor\tO\none\tO\nyear\tO\n.\tO\n\nThe\tO\nresults\tO\nshowed\tO\na\tO\nhigh\tO\nprevalence\tO\nof\tO\ndepression\tB-Disease\nin\tO\nboth\tO\ngroups\tO\nof\tO\npatients\tO\n,\tO\nwith\tO\nno\tO\npreponderance\tO\nin\tO\nthe\tO\nhypertensive\tB-Disease\ngroup\tO\n.\tO\n\nHypertensive\tB-Disease\npatients\tO\nwith\tO\npsychiatric\tB-Disease\nhistories\tO\nhad\tO\na\tO\nhigher\tO\nprevalence\tO\nof\tO\ndepression\tB-Disease\nthan\tO\nthe\tO\ncomparison\tO\npatients\tO\n.\tO\n\nThis\tO\nwas\tO\naccounted\tO\nfor\tO\nby\tO\na\tO\nsignificant\tO\nnumber\tO\nof\tO\ndepressions\tB-Disease\noccurring\tO\nin\tO\nmethyl\tB-Chemical\ndopa\tI-Chemical\ntreated\tO\npatients\tO\nwith\tO\npsychiatric\tB-Disease\nhistories\tO\n.\tO\n\nChronic\tB-Disease\nactive\tI-Disease\nhepatitis\tI-Disease\nassociated\tO\nwith\tO\ndiclofenac\tB-Chemical\nsodium\tI-Chemical\ntherapy\tO\n.\tO\n\nDiclofenac\tB-Chemical\nsodium\tI-Chemical\n(\tO\nVoltarol\tB-Chemical\n,\tO\nGeigy\tO\nPharmaceuticals\tO\n)\tO\nis\tO\na\tO\nnon\tO\n-\tO\nsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\nderivative\tO\nof\tO\nphenylacetic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nAlthough\tO\ngenerally\tO\nwell\tO\n-\tO\ntolerated\tO\n,\tO\nasymptomatic\tO\nabnormalities\tB-Disease\nof\tI-Disease\nliver\tI-Disease\nfunction\tI-Disease\nhave\tO\nbeen\tO\nrecorded\tO\nand\tO\n,\tO\nless\tO\ncommonly\tO\n,\tO\nsevere\tO\nhepatitis\tB-Disease\ninduced\tO\nby\tO\ndiclofenac\tB-Chemical\n.\tO\n\nThe\tO\npatient\tO\ndescribed\tO\ndeveloped\tO\nchronic\tB-Disease\nactive\tI-Disease\nhepatitis\tI-Disease\nafter\tO\nsix\tO\nmonths\tO\ntherapy\tO\nwith\tO\ndiclofenac\tB-Chemical\nsodium\tI-Chemical\nwhich\tO\nprogressed\tO\ndespite\tO\nthe\tO\nwithdrawal\tO\nof\tO\nthe\tO\ndrug\tO\n,\tO\na\tO\nfinding\tO\nnot\tO\npreviously\tO\nreported\tO\n.\tO\n\nArterial\tO\nhypertension\tB-Disease\nas\tO\na\tO\ncomplication\tO\nof\tO\nprolonged\tO\nketoconazole\tB-Chemical\ntreatment\tO\n.\tO\n\nTwo\tO\nof\tO\n14\tO\npatients\tO\nwith\tO\nCushing\tB-Disease\n'\tI-Disease\ns\tI-Disease\nsyndrome\tI-Disease\ntreated\tO\non\tO\na\tO\nlong\tO\n-\tO\nterm\tO\nbasis\tO\nwith\tO\nketoconazole\tB-Chemical\ndeveloped\tO\nsustained\tO\nhypertension\tB-Disease\n.\tO\n\nIn\tO\nboth\tO\ncases\tO\nnormal\tO\nplasma\tO\nand\tO\nurinary\tO\nfree\tO\ncortisol\tB-Chemical\nlevels\tO\nhad\tO\nbeen\tO\nachieved\tO\nfollowing\tO\nketoconazole\tB-Chemical\ntherapy\tO\n,\tO\nyet\tO\ncontinuous\tO\nblood\tO\npressure\tO\nmonitoring\tO\ndemonstrated\tO\nhypertension\tB-Disease\n31\tO\n(\tO\npatient\tO\n1\tO\n)\tO\nand\tO\n52\tO\nweeks\tO\n(\tO\npatient\tO\n2\tO\n)\tO\nafter\tO\ntreatment\tO\n.\tO\n\nIn\tO\npatient\tO\n1\tO\n,\tO\nplasma\tO\nlevels\tO\nof\tO\ndeoxycorticosterone\tB-Chemical\nand\tO\n11\tB-Chemical\n-\tI-Chemical\ndeoxycortisol\tI-Chemical\nwere\tO\nelevated\tO\n.\tO\n\nIn\tO\npatient\tO\n2\tO\n,\tO\nin\tO\naddition\tO\nto\tO\nan\tO\nincrease\tO\nin\tO\nboth\tO\ndeoxycorticosterone\tB-Chemical\nand\tO\n11\tB-Chemical\n-\tI-Chemical\ndeoxycortisol\tI-Chemical\nlevels\tO\n,\tO\nplasma\tO\naldosterone\tB-Chemical\nvalues\tO\nwere\tO\nraised\tO\n,\tO\nwith\tO\na\tO\nconcomitant\tO\nsuppression\tO\nof\tO\nrenin\tO\nlevels\tO\n.\tO\n\nOur\tO\nfindings\tO\nshow\tO\nthat\tO\nlong\tO\n-\tO\nterm\tO\ntreatment\tO\nwith\tO\nhigh\tO\ndoses\tO\nof\tO\nketoconazole\tB-Chemical\nmay\tO\ninduce\tO\nenzyme\tO\nblockade\tO\nleading\tO\nto\tO\nmineralocorticoid\tO\n-\tO\nrelated\tO\nhypertension\tB-Disease\n.\tO\n\nEffects\tO\nof\tO\nan\tO\ninhibitor\tO\nof\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\n(\tO\nCaptopril\tB-Chemical\n)\tO\non\tO\npulmonary\tB-Disease\nand\tI-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\ndue\tO\nto\tO\nintravascular\tB-Disease\ncoagulation\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nInduction\tO\nof\tO\nintravascular\tB-Disease\ncoagulation\tI-Disease\nand\tO\ninhibition\tO\nof\tO\nfibrinolysis\tO\nby\tO\ninjection\tO\nof\tO\nthrombin\tO\nand\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\n(\tO\nAMCA\tB-Chemical\n)\tO\nin\tO\nthe\tO\nrat\tO\ngives\tO\nrise\tO\nto\tO\npulmonary\tB-Disease\nand\tI-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\nresembling\tO\nthat\tO\noccurring\tO\nafter\tO\ntrauma\tB-Disease\nor\tO\nsepsis\tB-Disease\nin\tO\nman\tO\n.\tO\n\nInjection\tO\nof\tO\nCaptopril\tB-Chemical\n(\tO\n1\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n,\tO\nan\tO\ninhibitor\tO\nof\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\n(\tO\nACE\tO\n)\tO\n,\tO\nreduced\tO\nboth\tO\npulmonary\tB-Disease\nand\tI-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\nin\tO\nthis\tO\nrat\tO\nmodel\tO\n.\tO\n\nThe\tO\nlung\tO\nweights\tO\nwere\tO\nlower\tO\nand\tO\nPaO2\tO\nwas\tO\nimproved\tO\nin\tO\nrats\tO\ngiven\tO\nthis\tO\nenzyme\tO\n-\tO\nblocking\tO\nagent\tO\n.\tO\n\nThe\tO\ncontents\tO\nof\tO\nalbumin\tO\nin\tO\nthe\tO\nlungs\tO\nwere\tO\nnot\tO\nchanged\tO\n,\tO\nindicating\tO\nthat\tO\nCaptopril\tB-Chemical\ndid\tO\nnot\tO\ninfluence\tO\nthe\tO\nextravasation\tO\nof\tO\nprotein\tO\n.\tO\n\nRenal\tB-Disease\ndamage\tI-Disease\nas\tO\nreflected\tO\nby\tO\nan\tO\nincrease\tO\nin\tO\nserum\tO\nurea\tB-Chemical\nand\tO\nin\tO\nkidney\tO\nweight\tO\nwas\tO\nprevented\tO\nby\tO\nCaptopril\tB-Chemical\n.\tO\n\nThe\tO\namount\tO\nof\tO\nfibrin\tO\nin\tO\nthe\tO\nkidneys\tO\nwas\tO\nalso\tO\nconsiderably\tO\nlower\tO\nthan\tO\nin\tO\nanimals\tO\nwhich\tO\nreceived\tO\nthrombin\tO\nand\tO\nAMCA\tB-Chemical\nalone\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\nthe\tO\neffects\tO\nof\tO\nCaptopril\tB-Chemical\non\tO\nthe\tO\nlungs\tO\nmay\tO\nbe\tO\nattributable\tO\nto\tO\na\tO\nvasodilatory\tO\neffect\tO\ndue\tO\nto\tO\na\tO\nreduction\tO\nin\tO\nthe\tO\ncirculating\tO\nlevel\tO\nof\tO\nAngiotension\tB-Chemical\nII\tI-Chemical\nand\tO\nan\tO\nincrease\tO\nin\tO\nprostacyclin\tB-Chemical\n(\tO\nsecondary\tO\nto\tO\nan\tO\nincrease\tO\nin\tO\nbradykinin\tB-Chemical\n)\tO\n.\tO\n\nCaptopril\tB-Chemical\nmay\tO\n,\tO\nby\tO\nthe\tO\nsame\tO\nmechanism\tO\n,\tO\nreduce\tO\nthe\tO\nincrease\tO\nin\tO\nglomerular\tO\nfiltration\tO\nthat\tO\nis\tO\nknown\tO\nto\tO\noccur\tO\nafter\tO\nan\tO\ninjection\tO\nof\tO\nthrombin\tO\n,\tO\nthereby\tO\ndiminishing\tO\nthe\tO\naggregation\tO\nof\tO\nfibrin\tO\nmonomers\tO\nin\tO\nthe\tO\nglomeruli\tO\n,\tO\nwith\tO\nthe\tO\nresult\tO\nthat\tO\nless\tO\nfibrin\tO\nwill\tO\nbe\tO\ndeposited\tO\nand\tO\nthus\tO\nless\tO\nkidney\tB-Disease\ndamage\tI-Disease\nwill\tO\nbe\tO\nproduced\tO\n.\tO\n\nStroke\tB-Disease\nassociated\tO\nwith\tO\ncocaine\tB-Chemical\nuse\tO\n.\tO\n\nWe\tO\ndescribe\tO\neight\tO\npatients\tO\nin\tO\nwhom\tO\ncocaine\tB-Chemical\nuse\tO\nwas\tO\nrelated\tO\nto\tO\nstroke\tB-Disease\nand\tO\nreview\tO\n39\tO\ncases\tO\nfrom\tO\nthe\tO\nliterature\tO\n.\tO\n\nAmong\tO\nthese\tO\n47\tO\npatients\tO\nthe\tO\nmean\tO\n(\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nage\tO\nwas\tO\n32\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n12\tO\n.\tO\n1\tO\nyears\tO\n;\tO\n76\tO\n%\tO\n(\tO\n34\tO\n/\tO\n45\tO\n)\tO\nwere\tO\nmen\tO\n.\tO\n\nStroke\tB-Disease\nfollowed\tO\ncocaine\tB-Chemical\nuse\tO\nby\tO\ninhalation\tO\n,\tO\nintranasal\tO\n,\tO\nintravenous\tO\n,\tO\nand\tO\nintramuscular\tO\nroutes\tO\n.\tO\n\nIntracranial\tB-Disease\naneurysms\tI-Disease\nor\tO\narteriovenous\tB-Disease\nmalformations\tI-Disease\nwere\tO\npresent\tO\nin\tO\n17\tO\nof\tO\n32\tO\npatients\tO\nstudied\tO\nangiographically\tO\nor\tO\nat\tO\nautopsy\tO\n;\tO\ncerebral\tB-Disease\nvasculitis\tI-Disease\nwas\tO\npresent\tO\nin\tO\ntwo\tO\npatients\tO\n.\tO\n\nCerebral\tB-Disease\ninfarction\tI-Disease\noccurred\tO\nin\tO\n10\tO\npatients\tO\n(\tO\n22\tO\n%\tO\n)\tO\n,\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\nin\tO\n22\tO\n(\tO\n49\tO\n%\tO\n)\tO\n,\tO\nand\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\nin\tO\n13\tO\n(\tO\n29\tO\n%\tO\n)\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\n(\tO\n1\tO\n)\tO\nthe\tO\napparent\tO\nincidence\tO\nof\tO\nstroke\tB-Disease\nrelated\tO\nto\tO\ncocaine\tB-Chemical\nuse\tO\nis\tO\nincreasing\tO\n;\tO\n(\tO\n2\tO\n)\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nstroke\tB-Disease\noccurs\tO\nprimarily\tO\nin\tO\nyoung\tO\nadults\tO\n;\tO\n(\tO\n3\tO\n)\tO\nstroke\tB-Disease\nmay\tO\nfollow\tO\nany\tO\nroute\tO\nof\tO\ncocaine\tB-Chemical\nadministration\tO\n;\tO\n(\tO\n4\tO\n)\tO\nstroke\tB-Disease\nafter\tO\ncocaine\tB-Chemical\nuse\tO\nis\tO\nfrequently\tO\nassociated\tO\nwith\tO\nintracranial\tB-Disease\naneurysms\tI-Disease\nand\tO\narteriovenous\tB-Disease\nmalformations\tI-Disease\n;\tO\nand\tO\n(\tO\n5\tO\n)\tO\nin\tO\ncocaine\tB-Chemical\n-\tO\nassociated\tO\nstroke\tB-Disease\n,\tO\nthe\tO\nfrequency\tO\nof\tO\nintracranial\tB-Disease\nhemorrhage\tI-Disease\nexceeds\tO\nthat\tO\nof\tO\ncerebral\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nA\tO\nrandomized\tO\ncomparison\tO\nof\tO\nlabetalol\tB-Chemical\nand\tO\nnitroprusside\tB-Chemical\nfor\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nIn\tO\na\tO\nrandomized\tO\nstudy\tO\n,\tO\nlabetalol\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nand\tO\nnitroprusside\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nwere\tO\ncompared\tO\nin\tO\n20\tO\npatients\tO\n(\tO\n10\tO\nin\tO\neach\tO\ngroup\tO\n)\tO\nscheduled\tO\nfor\tO\nmajor\tO\northopedic\tO\nprocedures\tO\n.\tO\n\nEach\tO\npatient\tO\nwas\tO\nsubjected\tO\nto\tO\nan\tO\nidentical\tO\nanesthetic\tO\nprotocol\tO\nand\tO\nsimilar\tO\ndrug\tO\n-\tO\ninduced\tO\nreductions\tB-Disease\nin\tI-Disease\nmean\tI-Disease\narterial\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\n(\tO\nBP\tO\n)\tO\n(\tO\n50\tO\nto\tO\n55\tO\nmmHg\tO\n)\tO\n.\tO\n\nNitroprusside\tO\ninfusion\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\nsignificant\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nincrease\tB-Disease\nin\tI-Disease\nheart\tI-Disease\nrate\tI-Disease\nand\tI-Disease\ncardiac\tI-Disease\noutput\tI-Disease\n;\tO\nrebound\tO\nhypertension\tB-Disease\nwas\tO\nobserved\tO\nin\tO\nthree\tO\npatients\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nnitroprusside\tB-Chemical\n.\tO\n\nLabetalol\tB-Chemical\nadministration\tO\nwas\tO\nnot\tO\nassociated\tO\nwith\tO\nany\tO\nof\tO\nthese\tO\nfindings\tO\n.\tO\n\nArterial\tO\nPO2\tB-Chemical\ndecreased\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nIt\tO\nwas\tO\nconcluded\tO\nthat\tO\nlabetalol\tB-Chemical\noffers\tO\nadvantages\tO\nover\tO\nnitroprusside\tB-Chemical\n.\tO\n\nSodium\tB-Chemical\nstatus\tO\ninfluences\tO\nchronic\tO\namphotericin\tB-Chemical\nB\tI-Chemical\nnephrotoxicity\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nnephrotoxic\tB-Disease\npotential\tO\nof\tO\namphotericin\tB-Chemical\nB\tI-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\nintraperitoneally\tO\nfor\tO\n3\tO\nweeks\tO\n)\tO\nhas\tO\nbeen\tO\ninvestigated\tO\nin\tO\nsalt\tO\n-\tO\ndepleted\tO\n,\tO\nnormal\tO\n-\tO\nsalt\tO\n,\tO\nand\tO\nsalt\tO\n-\tO\nloaded\tO\nrats\tO\n.\tO\n\nIn\tO\nsalt\tO\n-\tO\ndepleted\tO\nrats\tO\n,\tO\namphotericin\tB-Chemical\nB\tI-Chemical\ndecreased\tO\ncreatinine\tB-Chemical\nclearance\tO\nlinearly\tO\nwith\tO\ntime\tO\n,\tO\nwith\tO\nan\tO\n85\tO\n%\tO\nreduction\tO\nby\tO\nweek\tO\n3\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nin\tO\nnormal\tO\n-\tO\nsalt\tO\nrats\tO\ncreatinine\tB-Chemical\nclearance\tO\nwas\tO\ndecreased\tO\nbut\tO\nto\tO\na\tO\nlesser\tO\nextent\tO\nat\tO\nweek\tO\n2\tO\nand\tO\n3\tO\n,\tO\nand\tO\nin\tO\nsalt\tO\n-\tO\nloaded\tO\nrats\tO\ncreatinine\tB-Chemical\nclearance\tO\ndid\tO\nnot\tO\nchange\tO\nfor\tO\n2\tO\nweeks\tO\nand\tO\nwas\tO\ndecreased\tO\nby\tO\n43\tO\n%\tO\nat\tO\nweek\tO\n3\tO\n.\tO\n\nAll\tO\nrats\tO\nin\tO\nthe\tO\nsodium\tB-Chemical\n-\tO\ndepleted\tO\ngroup\tO\nhad\tO\nhistopathological\tO\nevidence\tO\nof\tO\npatchy\tO\ntubular\tO\ncytoplasmic\tO\ndegeneration\tO\nin\tO\ntubules\tO\nthat\tO\nwas\tO\nnot\tO\nobserved\tO\nin\tO\nany\tO\nnormal\tO\n-\tO\nsalt\tO\nor\tO\nsalt\tO\n-\tO\nloaded\tO\nrat\tO\n.\tO\n\nConcentrations\tO\nof\tO\namphotericin\tB-Chemical\nB\tI-Chemical\nin\tO\nplasma\tO\nwere\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\namong\tO\nthe\tO\nthree\tO\ngroups\tO\nat\tO\nany\tO\ntime\tO\nduring\tO\nthe\tO\nstudy\tO\n.\tO\n\nHowever\tO\n,\tO\nat\tO\nthe\tO\nend\tO\nof\tO\n3\tO\nweeks\tO\n,\tO\namphotericin\tB-Chemical\nB\tI-Chemical\nlevels\tO\nin\tO\nthe\tO\nkidneys\tO\nand\tO\nliver\tO\nwere\tO\nsignificantly\tO\nhigher\tO\nin\tO\nsalt\tO\n-\tO\ndepleted\tO\nand\tO\nnormal\tO\n-\tO\nsalt\tO\nrats\tO\nthan\tO\nthose\tO\nin\tO\nsalt\tO\n-\tO\nloaded\tO\nrats\tO\n,\tO\nwith\tO\nplasma\tO\n/\tO\nkidney\tO\nratios\tO\nof\tO\n21\tO\n,\tO\n14\tO\n,\tO\nand\tO\n8\tO\nin\tO\nsalt\tO\n-\tO\ndepleted\tO\n,\tO\nnormal\tO\n-\tO\nsalt\tO\n,\tO\nand\tO\nsalt\tO\n-\tO\nloaded\tO\nrats\tO\n,\tO\nrespectively\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nreductions\tO\nin\tO\ncreatinine\tB-Chemical\nclearance\tO\nand\tO\nrenal\tO\namphotericin\tB-Chemical\nB\tI-Chemical\naccumulation\tO\nafter\tO\nchronic\tO\namphotericin\tB-Chemical\nB\tI-Chemical\nadministration\tO\nwere\tO\nenhanced\tO\nby\tO\nsalt\tO\ndepletion\tO\nand\tO\nattenuated\tO\nby\tO\nsodium\tB-Chemical\nloading\tO\nin\tO\nrats\tO\n.\tO\n\nFlestolol\tB-Chemical\n:\tO\nan\tO\nultra\tO\n-\tO\nshort\tO\n-\tO\nacting\tO\nbeta\tO\n-\tO\nadrenergic\tO\nblocking\tO\nagent\tO\n.\tO\n\nFlestolol\tB-Chemical\n(\tO\nACC\tB-Chemical\n-\tI-Chemical\n9089\tI-Chemical\n)\tO\nis\tO\na\tO\nnonselective\tO\n,\tO\ncompetitive\tO\n,\tO\nultra\tO\n-\tO\nshort\tO\n-\tO\nacting\tO\nbeta\tO\n-\tO\nadrenergic\tO\nblocking\tO\nagent\tO\n,\tO\nwithout\tO\nany\tO\nintrinsic\tO\nsympathomimetic\tO\nactivity\tO\n.\tO\n\nFlestolol\tB-Chemical\nis\tO\nmetabolized\tO\nby\tO\nplasma\tO\nesterases\tO\nand\tO\nhas\tO\nan\tO\nelimination\tO\nhalf\tO\n-\tO\nlife\tO\nof\tO\napproximately\tO\n6\tO\n.\tO\n5\tO\nminutes\tO\n.\tO\n\nThis\tO\nagent\tO\nwas\tO\nwell\tO\ntolerated\tO\nin\tO\nhealthy\tO\nvolunteers\tO\nat\tO\ndoses\tO\nup\tO\nto\tO\n100\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n.\tO\n\nIn\tO\nlong\tO\n-\tO\nterm\tO\ninfusion\tO\nstudies\tO\n,\tO\nflestolol\tB-Chemical\nwas\tO\nwell\tO\ntolerated\tO\nat\tO\nthe\tO\neffective\tO\nbeta\tO\n-\tO\nblocking\tO\ndose\tO\n(\tO\n5\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n)\tO\nfor\tO\nup\tO\nto\tO\nseven\tO\ndays\tO\n.\tO\n\nFlestolol\tB-Chemical\nblood\tO\nconcentrations\tO\nincreased\tO\nlinearly\tO\nwith\tO\nincreasing\tO\ndose\tO\nand\tO\ngood\tO\ncorrelation\tO\nexists\tO\nbetween\tO\nblood\tO\nconcentrations\tO\nof\tO\nflestolol\tB-Chemical\nand\tO\nbeta\tO\n-\tO\nadrenergic\tO\nblockade\tO\n.\tO\n\nFlestolol\tB-Chemical\nproduced\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nattenuation\tO\nof\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\n.\tO\n\nElectrophysiologic\tO\nand\tO\nhemodynamic\tO\neffects\tO\nof\tO\nflestolol\tB-Chemical\nare\tO\nsimilar\tO\nto\tO\nthose\tO\nof\tO\nother\tO\nbeta\tO\nblockers\tO\n.\tO\n\nIn\tO\ncontrast\tO\nwith\tO\nother\tO\nbeta\tO\nblockers\tO\n,\tO\nflestolol\tB-Chemical\n-\tO\ninduced\tO\neffects\tO\nreverse\tO\nrapidly\tO\n(\tO\nwithin\tO\n30\tO\nminutes\tO\n)\tO\nfollowing\tO\ndiscontinuation\tO\nbecause\tO\nof\tO\nits\tO\nshort\tO\nhalf\tO\n-\tO\nlife\tO\n.\tO\n\nFlestolol\tB-Chemical\neffectively\tO\nreduced\tO\nheart\tO\nrate\tO\nin\tO\npatients\tO\nwith\tO\nsupraventricular\tB-Disease\ntachyarrhythmia\tI-Disease\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\nunstable\tB-Disease\nangina\tI-Disease\n,\tO\nflestolol\tB-Chemical\ninfusion\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\nsafe\tO\nand\tO\neffective\tO\nin\tO\ncontrolling\tO\nchest\tB-Disease\npain\tI-Disease\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nflestolol\tB-Chemical\nis\tO\na\tO\npotent\tO\n,\tO\nwell\tO\n-\tO\ntolerated\tO\n,\tO\nultra\tO\n-\tO\nshort\tO\n-\tO\nacting\tO\nbeta\tO\n-\tO\nadrenergic\tO\nblocking\tO\nagent\tO\n.\tO\n\nUse\tO\nof\tO\nflestolol\tB-Chemical\nin\tO\nthe\tO\ncritical\tO\ncare\tO\nsetting\tO\nis\tO\ncurrently\tO\nundergoing\tO\ninvestigation\tO\n.\tO\n\nImmunohistochemical\tO\n,\tO\nelectron\tO\nmicroscopic\tO\nand\tO\nmorphometric\tO\nstudies\tO\nof\tO\nestrogen\tB-Chemical\n-\tO\ninduced\tO\nrat\tO\nprolactinomas\tB-Disease\nafter\tO\nbromocriptine\tB-Chemical\ntreatment\tO\n.\tO\n\nTo\tO\nclarify\tO\nthe\tO\neffects\tO\nof\tO\nbromocriptine\tB-Chemical\non\tO\nprolactinoma\tB-Disease\ncells\tO\nin\tO\nvivo\tO\n,\tO\nimmunohistochemical\tO\n,\tO\nultrastructural\tO\nand\tO\nmorphometrical\tO\nanalyses\tO\nwere\tO\napplied\tO\nto\tO\nestrogen\tB-Chemical\n-\tO\ninduced\tO\nrat\tO\nprolactinoma\tB-Disease\ncells\tO\n1\tO\nh\tO\nand\tO\n6\tO\nh\tO\nafter\tO\ninjection\tO\nof\tO\nbromocriptine\tB-Chemical\n(\tO\n3\tO\nmg\tO\n/\tO\nkg\tO\nof\tO\nbody\tO\nweight\tO\n)\tO\n.\tO\n\nOne\tO\nh\tO\nafter\tO\ntreatment\tO\n,\tO\nserum\tO\nprolactin\tO\nlevels\tO\ndecreased\tO\nmarkedly\tO\n.\tO\n\nElectron\tO\nmicroscopy\tO\ndisclosed\tO\nmany\tO\nsecretory\tO\ngranules\tO\n,\tO\nslightly\tO\ndistorted\tO\nrough\tO\nendoplasmic\tO\nreticulum\tO\n,\tO\nand\tO\npartially\tO\ndilated\tO\nGolgi\tO\ncisternae\tO\nin\tO\nthe\tO\nprolactinoma\tB-Disease\ncells\tO\n.\tO\n\nMorphometric\tO\nanalysis\tO\nrevealed\tO\nthat\tO\nthe\tO\nvolume\tO\ndensity\tO\nof\tO\nsecretory\tO\ngranules\tO\nincreased\tO\n,\tO\nwhile\tO\nthe\tO\nvolume\tO\ndensity\tO\nof\tO\ncytoplasmic\tO\nmicrotubules\tO\ndecreased\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nlowered\tO\nserum\tO\nprolactin\tO\nlevels\tO\nin\tO\nthe\tO\nearly\tO\nphase\tO\nof\tO\nbromocriptine\tB-Chemical\ntreatment\tO\nmay\tO\nresult\tO\nfrom\tO\nan\tO\nimpaired\tO\nsecretion\tO\nof\tO\nprolactin\tO\ndue\tO\nto\tO\ndecreasing\tO\nnumbers\tO\nof\tO\ncytoplasmic\tO\nmicrotubules\tO\n.\tO\n\nAt\tO\n6\tO\nh\tO\nafter\tO\ninjection\tO\n,\tO\nserum\tO\nprolactin\tO\nlevels\tO\nwere\tO\nstill\tO\nconsiderably\tO\nlower\tO\nthan\tO\nin\tO\ncontrols\tO\n.\tO\n\nThe\tO\nprolactinoma\tB-Disease\ncells\tO\nat\tO\nthis\tO\ntime\tO\nwere\tO\nwell\tO\ngranulated\tO\n,\tO\nwith\tO\nvesiculated\tO\nrough\tO\nendoplasmic\tO\nreticulum\tO\nand\tO\nmarkedly\tO\ndilated\tO\nGolgi\tO\ncisternae\tO\n.\tO\n\nElectron\tO\nmicroscopical\tO\nimmunohistochemistry\tO\nrevealed\tO\npositive\tO\nreaction\tO\nproducts\tO\nnoted\tO\non\tO\nthe\tO\nsecretory\tO\ngranules\tO\n,\tO\nGolgi\tO\ncisternae\tO\n,\tO\nand\tO\nendoplasmic\tO\nreticulum\tO\nof\tO\nthe\tO\nuntreated\tO\nrat\tO\nprolactinoma\tB-Disease\ncells\tO\n.\tO\n\nHowever\tO\n,\tO\nonly\tO\nsecretory\tO\ngranules\tO\nshowed\tO\nthe\tO\npositive\tO\nreaction\tO\nproducts\tO\nfor\tO\nprolactin\tO\n6\tO\nh\tO\nafter\tO\nbromocriptine\tB-Chemical\ntreatment\tO\nof\tO\nthe\tO\nadenoma\tB-Disease\ncells\tO\n.\tO\n\nAn\tO\nincrease\tO\nin\tO\nthe\tO\nvolume\tO\ndensity\tO\nof\tO\nsecretory\tO\ngranules\tO\nand\tO\na\tO\ndecrease\tO\nin\tO\nthe\tO\nvolume\tO\ndensities\tO\nof\tO\nrough\tO\nendoplasmic\tO\nreticulum\tO\nand\tO\nmicrotubules\tO\nwas\tO\ndetermined\tO\nby\tO\nmorphometric\tO\nanalysis\tO\n,\tO\nsuggesting\tO\nthat\tO\nbromocriptine\tB-Chemical\ninhibits\tO\nprotein\tO\nsynthesis\tO\nas\tO\nwell\tO\nas\tO\nbringing\tO\nabout\tO\na\tO\ndisturbance\tO\nof\tO\nthe\tO\nprolactin\tO\nsecretion\tO\n.\tO\n\nSulfasalazine\tB-Chemical\n-\tO\ninduced\tO\nlupus\tB-Disease\nerythematosus\tI-Disease\n.\tO\n\nPneumonitis\tB-Disease\n,\tO\nbilateral\tO\npleural\tB-Disease\neffusions\tI-Disease\n,\tO\nechocardiographic\tO\nevidence\tO\nof\tO\ncardiac\tB-Disease\ntamponade\tI-Disease\n,\tO\nand\tO\npositive\tO\nautoantibodies\tO\ndeveloped\tO\nin\tO\na\tO\n43\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\n,\tO\nwho\tO\nwas\tO\nreceiving\tO\nlong\tO\n-\tO\nterm\tO\nsulfasalazine\tB-Chemical\ntherapy\tO\nfor\tO\nchronic\tO\nulcerative\tB-Disease\ncolitis\tI-Disease\n.\tO\n\nAfter\tO\ncessation\tO\nof\tO\nthe\tO\nsulfasalazine\tB-Chemical\nand\tO\ncompletion\tO\nof\tO\na\tO\nsix\tO\n-\tO\nweek\tO\ncourse\tO\nof\tO\ncorticosteroids\tO\n,\tO\nthese\tO\nproblems\tO\nresolved\tO\nover\tO\na\tO\nperiod\tO\nof\tO\nfour\tO\nto\tO\nsix\tO\nmonths\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\nthe\tO\npatient\tO\nhad\tO\nsulfasalazine\tB-Chemical\n-\tO\ninduced\tO\nlupus\tB-Disease\n,\tO\nwhich\tO\nmanifested\tO\nwith\tO\nserositis\tB-Disease\nand\tO\npulmonary\tO\nparenchymal\tO\ninvolvement\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\njoint\tO\nsymptoms\tO\n.\tO\n\nPhysicians\tO\nwho\tO\nuse\tO\nsulfasalazine\tB-Chemical\nto\tO\ntreat\tO\npatients\tO\nwith\tO\ninflammatory\tB-Disease\nbowel\tI-Disease\ndisease\tI-Disease\nshould\tO\nbe\tO\naware\tO\nof\tO\nthe\tO\nsigns\tO\nof\tO\nsulfasalazine\tB-Chemical\n-\tO\ninduced\tO\nlupus\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nChronic\tO\ncarbamazepine\tB-Chemical\ntreatment\tO\nin\tO\nthe\tO\nrat\tO\n:\tO\nefficacy\tO\n,\tO\ntoxicity\tB-Disease\n,\tO\nand\tO\neffect\tO\non\tO\nplasma\tO\nand\tO\ntissue\tO\nfolate\tB-Chemical\nconcentrations\tO\n.\tO\n\nFolate\tB-Chemical\ndepletion\tO\nhas\tO\noften\tO\nbeen\tO\na\tO\nproblem\tO\nin\tO\nchronic\tO\nantiepileptic\tO\ndrug\tO\n(\tO\nAED\tO\n)\tO\ntherapy\tO\n.\tO\n\nCarbamazepine\tB-Chemical\n(\tO\nCBZ\tB-Chemical\n)\tO\n,\tO\na\tO\ncommonly\tO\nused\tO\nAED\tO\n,\tO\nhas\tO\nbeen\tO\nimplicated\tO\nin\tO\nsome\tO\nclinical\tO\nstudies\tO\n.\tO\n\nA\tO\nrat\tO\nmodel\tO\nwas\tO\ndeveloped\tO\nto\tO\nexamine\tO\nthe\tO\neffects\tO\nof\tO\nchronic\tO\nCBZ\tB-Chemical\ntreatment\tO\non\tO\nfolate\tB-Chemical\nconcentrations\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nIn\tO\nthe\tO\ncourse\tO\nof\tO\ndeveloping\tO\nthis\tO\nmodel\tO\n,\tO\na\tO\ncommon\tO\nvehicle\tO\n,\tO\npropylene\tB-Chemical\nglycol\tI-Chemical\n,\tO\nby\tO\nitself\tO\nin\tO\nhigh\tO\ndoses\tO\n,\tO\nwas\tO\nfound\tO\nto\tO\nexhibit\tO\nprotective\tO\nproperties\tO\nagainst\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\ninhibited\tO\nweight\tB-Disease\ngain\tI-Disease\n.\tO\n\nSeizures\tB-Disease\ninduced\tO\nby\tO\nhexafluorodiethyl\tB-Chemical\nether\tI-Chemical\n(\tO\nHFDE\tB-Chemical\n)\tO\nwere\tO\nalso\tO\nfound\tO\nto\tO\nbe\tO\na\tO\nmore\tO\nsensitive\tO\nmeasure\tO\nof\tO\nprotection\tO\nby\tO\nCBZ\tB-Chemical\nthan\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\nmaximal\tO\nelectroshock\tO\n(\tO\nMES\tO\n)\tO\n.\tO\n\nOral\tO\nadministration\tO\nof\tO\nCBZ\tB-Chemical\nas\tO\nan\tO\naqueous\tO\nsuspension\tO\nevery\tO\n8\tO\nh\tO\nat\tO\na\tO\ndose\tO\nof\tO\n250\tO\nmg\tO\n/\tO\nkg\tO\nwas\tO\ncontinuously\tO\nprotective\tO\nagainst\tO\nHFDE\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nand\tO\nwas\tO\nminimally\tO\ntoxic\tO\nas\tO\nmeasured\tO\nby\tO\nweight\tB-Disease\ngain\tI-Disease\nover\tO\n8\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nThe\tO\nCBZ\tB-Chemical\nlevels\tO\nmeasured\tO\nin\tO\nplasma\tO\nand\tO\nbrain\tO\nof\tO\nthese\tO\nanimals\tO\n,\tO\nhowever\tO\n,\tO\nwere\tO\nbelow\tO\nthose\tO\nnormally\tO\nconsidered\tO\nprotective\tO\n.\tO\n\nThis\tO\ntreatment\tO\nwith\tO\nCBZ\tB-Chemical\nhad\tO\nno\tO\napparent\tO\nadverse\tO\neffect\tO\non\tO\nfolate\tB-Chemical\nconcentrations\tO\nin\tO\nthe\tO\nrat\tO\n,\tO\nand\tO\n,\tO\nindeed\tO\n,\tO\nthe\tO\nfolate\tB-Chemical\nconcentration\tO\nincreased\tO\nin\tO\nliver\tO\nafter\tO\n6\tO\nweeks\tO\nof\tO\ntreatment\tO\nand\tO\nin\tO\nplasma\tO\nat\tO\n8\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nDipyridamole\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n.\tO\n\nAngina\tB-Disease\nand\tO\nischemic\tO\nelectrocardiographic\tO\nchanges\tO\noccurred\tO\nafter\tO\nadministration\tO\nof\tO\noral\tO\ndipyridamole\tB-Chemical\nin\tO\nfour\tO\npatients\tO\nawaiting\tO\nurgent\tO\nmyocardial\tO\nrevascularization\tO\nprocedures\tO\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nhas\tO\nnot\tO\npreviously\tO\nbeen\tO\nreported\tO\nas\tO\na\tO\nside\tO\neffect\tO\nof\tO\npreoperative\tO\ndipyridamole\tB-Chemical\ntherapy\tO\n,\tO\nalthough\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\nhas\tO\nbeen\tO\ndemonstrated\tO\nto\tO\noccur\tO\nin\tO\nanimals\tO\nand\tO\nhumans\tO\nwith\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\n.\tO\n\nEpicardial\tO\ncoronary\tO\ncollateral\tO\nvessels\tO\nwere\tO\ndemonstrated\tO\nin\tO\nall\tO\nfour\tO\npatients\tO\n;\tO\na\tO\ncoronary\tO\n\"\tO\nsteal\tO\n\"\tO\nphenomenon\tO\nmay\tO\nbe\tO\nthe\tO\nmechanism\tO\nof\tO\nthe\tO\ndipyridamole\tB-Chemical\n-\tO\ninduced\tO\nischemia\tB-Disease\nobserved\tO\n.\tO\n\nInhibition\tO\nof\tO\nsympathoadrenal\tO\nactivity\tO\nby\tO\natrial\tO\nnatriuretic\tO\nfactor\tO\nin\tO\ndogs\tO\n.\tO\n\nIn\tO\nsix\tO\nconscious\tO\n,\tO\ntrained\tO\ndogs\tO\n,\tO\nmaintained\tO\non\tO\na\tO\nnormal\tO\nsodium\tB-Chemical\nintake\tO\nof\tO\n2\tO\nto\tO\n4\tO\nmEq\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n,\tO\nsympathetic\tO\nactivity\tO\nwas\tO\nassessed\tO\nas\tO\nthe\tO\nrelease\tO\nrate\tO\nof\tO\nnorepinephrine\tB-Chemical\nand\tO\nepinephrine\tB-Chemical\nduring\tO\n15\tO\n-\tO\nminute\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusions\tO\nof\tO\nhuman\tO\nalpha\tO\n-\tO\natrial\tO\nnatriuretic\tO\nfactor\tO\n.\tO\n\nMean\tO\narterial\tO\npressure\tO\n(\tO\nas\tO\na\tO\npercentage\tO\nof\tO\ncontrol\tO\n+\tO\n/\tO\n-\tO\nSEM\tO\n)\tO\nduring\tO\nrandomized\tO\ninfusions\tO\nof\tO\n0\tO\n.\tO\n03\tO\n,\tO\n0\tO\n.\tO\n1\tO\n,\tO\n0\tO\n.\tO\n3\tO\n,\tO\nor\tO\n1\tO\n.\tO\n0\tO\nmicrogram\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\nwas\tO\n99\tO\n+\tO\n/\tO\n-\tO\n1\tO\n,\tO\n95\tO\n+\tO\n/\tO\n-\tO\n1\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\n93\tO\n+\tO\n/\tO\n-\tO\n1\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nor\tO\n79\tO\n+\tO\n/\tO\n-\tO\n6\tO\n%\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrespectively\tO\n,\tO\nbut\tO\nno\tO\ntachycardia\tB-Disease\nand\tO\nno\tO\naugmentation\tO\nof\tO\nthe\tO\nnorepinephrine\tB-Chemical\nrelease\tO\nrate\tO\n(\tO\nup\tO\nto\tO\n0\tO\n.\tO\n3\tO\nmicrogram\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n)\tO\nwere\tO\nobserved\tO\n,\tO\nwhich\tO\nis\tO\nin\tO\ncontrast\tO\nto\tO\ncomparable\tO\nhypotension\tB-Disease\ninduced\tO\nby\tO\nhydralazine\tB-Chemical\nor\tO\nnitroglycerin\tB-Chemical\n.\tO\n\nThe\tO\nrelease\tO\nrate\tO\nof\tO\nepinephrine\tB-Chemical\n(\tO\ncontrol\tO\n,\tO\n6\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n6\tO\nng\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n)\tO\ndeclined\tO\nimmediately\tO\nduring\tO\ninfusions\tO\nof\tO\natrial\tO\nnatriuretic\tO\nfactor\tO\nto\tO\na\tO\nminimum\tO\nof\tO\n49\tO\n+\tO\n/\tO\n-\tO\n5\tO\n%\tO\nof\tO\ncontrol\tO\n(\tO\np\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\nduring\tO\n0\tO\n.\tO\n1\tO\nmicrogram\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\nand\tO\nto\tO\n63\tO\n+\tO\n/\tO\n-\tO\n5\tO\n%\tO\n(\tO\n0\tO\n.\tO\n1\tO\ngreater\tO\nthan\tO\np\tO\ngreater\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nor\tO\n95\tO\n+\tO\n/\tO\n-\tO\n13\tO\n%\tO\n(\tO\nnot\tO\nsignificant\tO\n)\tO\nduring\tO\n0\tO\n.\tO\n3\tO\nor\tO\n1\tO\n.\tO\n0\tO\nmicrogram\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n.\tO\n\nSteady\tO\nstate\tO\narterial\tO\nplasma\tO\nconcentrations\tO\nof\tO\natrial\tO\nnatriuretic\tO\nfactor\tO\nwere\tO\n39\tO\n+\tO\n/\tO\n-\tO\n10\tO\npg\tO\n/\tO\nml\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nduring\tO\ninfusions\tO\nof\tO\nsaline\tO\nand\tO\n284\tO\n+\tO\n/\tO\n-\tO\n24\tO\npg\tO\n/\tO\nml\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nand\tO\n1520\tO\n+\tO\n/\tO\n-\tO\n300\tO\npg\tO\n/\tO\nml\tO\n(\tO\nn\tO\n=\tO\n9\tO\n)\tO\nduring\tO\n0\tO\n.\tO\n03\tO\nand\tO\n0\tO\n.\tO\n1\tO\nmicrogram\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\ninfusions\tO\nof\tO\nthe\tO\nfactor\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nInhibition\tO\nof\tO\nimmunoreactive\tO\ncorticotropin\tO\n-\tO\nreleasing\tO\nfactor\tO\nsecretion\tO\ninto\tO\nthe\tO\nhypophysial\tO\n-\tO\nportal\tO\ncirculation\tO\nby\tO\ndelayed\tO\nglucocorticoid\tO\nfeedback\tO\n.\tO\n\nNitroprusside\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nevokes\tO\nACTH\tO\nsecretion\tO\nwhich\tO\nis\tO\nprimarily\tO\nmediated\tO\nby\tO\nenhanced\tO\nsecretion\tO\nof\tO\nimmunoreactive\tO\ncorticotropin\tO\n-\tO\nreleasing\tO\nfactor\tO\n(\tO\nirCRF\tO\n)\tO\ninto\tO\nthe\tO\nhypophysial\tO\n-\tO\nportal\tO\ncirculation\tO\n.\tO\n\nPortal\tO\nplasma\tO\nconcentrations\tO\nof\tO\nneither\tO\narginine\tB-Chemical\nvasopressin\tI-Chemical\nnor\tO\noxytocin\tB-Chemical\nare\tO\nsignificantly\tO\naltered\tO\nin\tO\nthis\tO\nparadigm\tO\n.\tO\n\nApplication\tO\nof\tO\na\tO\ndelayed\tO\nfeedback\tO\nsignal\tO\n,\tO\nin\tO\nthe\tO\nform\tO\nof\tO\na\tO\n2\tO\n-\tO\nh\tO\nsystemic\tO\ncorticosterone\tB-Chemical\ninfusion\tO\nin\tO\nurethane\tB-Chemical\n-\tO\nanesthetized\tO\nrats\tO\nwith\tO\npharmacological\tO\nblockade\tO\nof\tO\nglucocorticoid\tO\nsynthesis\tO\n,\tO\nis\tO\nwithout\tO\neffect\tO\non\tO\nthe\tO\nresting\tO\nsecretion\tO\nof\tO\narginine\tB-Chemical\nvasopressin\tI-Chemical\nand\tO\noxytocin\tB-Chemical\nat\tO\nany\tO\ncorticosterone\tB-Chemical\nfeedback\tO\ndose\tO\ntested\tO\n.\tO\n\nResting\tO\nirCRF\tO\nlevels\tO\nare\tO\nsuppressed\tO\nonly\tO\nat\tO\nthe\tO\nhighest\tO\ncorticosterone\tB-Chemical\ninfusion\tO\nrate\tO\n,\tO\nwhich\tO\nresulted\tO\nin\tO\nsystemic\tO\ncorticosterone\tB-Chemical\nlevels\tO\nof\tO\n40\tO\nmicrograms\tO\n/\tO\ndl\tO\n.\tO\n\nSuppression\tO\nof\tO\nirCRF\tO\nsecretion\tO\nin\tO\nresponse\tO\nto\tO\nnitroprusside\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nis\tO\nobserved\tO\nand\tO\noccurs\tO\nat\tO\na\tO\nplasma\tO\ncorticosterone\tB-Chemical\nlevel\tO\nbetween\tO\n8\tO\n-\tO\n12\tO\nmicrograms\tO\n/\tO\ndl\tO\n.\tO\n\nThese\tO\nstudies\tO\nprovide\tO\nfurther\tO\nevidence\tO\nfor\tO\na\tO\nstrong\tO\ncentral\tO\ncomponent\tO\nof\tO\nthe\tO\ndelayed\tO\nfeedback\tO\nprocess\tO\nwhich\tO\nis\tO\nmediated\tO\nby\tO\nmodulation\tO\nof\tO\nirCRF\tO\nrelease\tO\n.\tO\n\nNoradrenergic\tO\ninvolvement\tO\nin\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\ndelta\tB-Chemical\n9\tI-Chemical\n-\tI-Chemical\ntetrahydrocannabinol\tI-Chemical\n.\tO\n\nIn\tO\norder\tO\nto\tO\nelucidate\tO\nthe\tO\nrole\tO\nof\tO\nthe\tO\ncatecholaminergic\tO\nsystem\tO\nin\tO\nthe\tO\ncataleptogenic\tO\neffect\tO\nof\tO\ndelta\tB-Chemical\n9\tI-Chemical\n-\tI-Chemical\ntetrahydrocannabinol\tI-Chemical\n(\tO\nTHC\tB-Chemical\n)\tO\n,\tO\nthe\tO\neffect\tO\nof\tO\npretreatment\tO\nwith\tO\n6\tB-Chemical\n-\tI-Chemical\nhydroxydopamine\tI-Chemical\n(\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\n)\tO\nor\tO\nwith\tO\ndesipramine\tB-Chemical\nand\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\nand\tO\nlesions\tO\nof\tO\nthe\tO\nlocus\tO\ncoeruleus\tO\nwere\tO\ninvestigated\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\ncataleptogenic\tO\neffect\tO\nof\tO\nTHC\tB-Chemical\nwas\tO\nsignificantly\tO\nreduced\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\nand\tO\nin\tO\nrats\tO\nwith\tO\nlesions\tO\nof\tO\nthe\tO\nlocus\tO\ncoeruleus\tO\nbut\tO\nnot\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ndesipramine\tB-Chemical\nand\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\n,\tO\nas\tO\ncompared\tO\nwith\tO\ncontrol\tO\nrats\tO\n.\tO\n\nOn\tO\nthe\tO\ncontrary\tO\n,\tO\nthe\tO\ncataleptogenic\tO\neffect\tO\nof\tO\nhaloperidol\tB-Chemical\nwas\tO\nsignificantly\tO\nreduced\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ndesipramine\tB-Chemical\nand\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\nbut\tO\nnot\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\n6\tB-Chemical\n-\tI-Chemical\nOHDA\tI-Chemical\nor\tO\nin\tO\nrats\tO\nwith\tO\nlesions\tO\nof\tO\nthe\tO\nlocus\tO\ncoeruleus\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nnoradrenergic\tO\nneurons\tO\nhave\tO\nan\tO\nimportant\tO\nrole\tO\nin\tO\nthe\tO\nmanifestation\tO\nof\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nTHC\tB-Chemical\n,\tO\nwhereas\tO\ndopaminergic\tO\nneurons\tO\nare\tO\nimportant\tO\nin\tO\ncatalepsy\tB-Disease\ninduced\tO\nby\tO\nhaloperidol\tB-Chemical\n.\tO\n\nReversibility\tO\nof\tO\ncaptopril\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\nafter\tO\nprolonged\tO\nuse\tO\nin\tO\nan\tO\nunusual\tO\ncase\tO\nof\tO\nrenovascular\tB-Disease\nhypertension\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nsevere\tO\nhypertension\tB-Disease\nwith\tO\nan\tO\noccluded\tO\nrenal\tO\nartery\tO\nto\tO\na\tO\nsolitary\tO\nkidney\tO\n,\tO\nwho\tO\ndeveloped\tO\nsudden\tB-Disease\ndeterioration\tI-Disease\nof\tI-Disease\nrenal\tI-Disease\nfunction\tI-Disease\nfollowing\tO\ntreatment\tO\nwith\tO\ncaptopril\tB-Chemical\n.\tO\n\nHis\tO\nrenal\tO\nfunction\tO\nremained\tO\nimpaired\tO\nbut\tO\nstable\tO\nduring\tO\n2\tO\nyears\tO\n'\tO\ntreatment\tO\nwith\tO\ncaptopril\tB-Chemical\nbut\tO\nreturned\tO\nto\tO\npre\tO\n-\tO\ntreatment\tO\nlevels\tO\nsoon\tO\nafter\tO\ncessation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nThis\tO\nindicates\tO\nreversibility\tO\nin\tO\ncaptopril\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\nfailure\tI-Disease\neven\tO\nafter\tO\nits\tO\nprolonged\tO\nuse\tO\nand\tO\nsuggests\tO\nthat\tO\nno\tO\norganic\tO\ndamage\tO\noccurs\tO\nto\tO\nglomerular\tO\narterioles\tO\nfollowing\tO\nchronic\tO\nACE\tO\ninhibition\tO\n.\tO\n\nHMG\tO\nCoA\tO\nreductase\tO\ninhibitors\tO\n.\tO\n\nCurrent\tO\nclinical\tO\nexperience\tO\n.\tO\n\nLovastatin\tB-Chemical\nand\tO\nsimvastatin\tB-Chemical\nare\tO\nthe\tO\n2\tO\nbest\tO\n-\tO\nknown\tO\nmembers\tO\nof\tO\nthe\tO\nclass\tO\nof\tO\nhypolipidaemic\tO\nagents\tO\nknown\tO\nas\tO\nHMG\tO\nCoA\tO\nreductase\tO\ninhibitors\tO\n.\tO\n\nClinical\tO\nexperience\tO\nwith\tO\nlovastatin\tB-Chemical\nincludes\tO\nover\tO\n5000\tO\npatients\tO\n,\tO\n700\tO\nof\tO\nwhom\tO\nhave\tO\nbeen\tO\ntreated\tO\nfor\tO\n2\tO\nyears\tO\nor\tO\nmore\tO\n,\tO\nand\tO\nexperience\tO\nwith\tO\nsimvastatin\tB-Chemical\nincludes\tO\nover\tO\n3500\tO\npatients\tO\n,\tO\nof\tO\nwhom\tO\n350\tO\nhave\tO\nbeen\tO\ntreated\tO\nfor\tO\n18\tO\nmonths\tO\nor\tO\nmore\tO\n.\tO\n\nLovastatin\tB-Chemical\nhas\tO\nbeen\tO\nmarketed\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\nfor\tO\nover\tO\n6\tO\nmonths\tO\n.\tO\n\nBoth\tO\nagents\tO\nshow\tO\nsubstantial\tO\nclinical\tO\nefficacy\tO\n,\tO\nwith\tO\nreductions\tO\nin\tO\ntotal\tO\ncholesterol\tB-Chemical\nof\tO\nover\tO\n30\tO\n%\tO\nand\tO\nin\tO\nLDL\tO\n-\tO\ncholesterol\tB-Chemical\nof\tO\n40\tO\n%\tO\nin\tO\nclinical\tO\nstudies\tO\n.\tO\n\nModest\tO\nincreases\tO\nin\tO\nHDL\tO\n-\tO\ncholesterol\tB-Chemical\nlevels\tO\nof\tO\nabout\tO\n10\tO\n%\tO\nare\tO\nalso\tO\nreported\tO\n.\tO\n\nClinical\tO\ntolerability\tO\nof\tO\nboth\tO\nagents\tO\nhas\tO\nbeen\tO\ngood\tO\n,\tO\nwith\tO\nfewer\tO\nthan\tO\n3\tO\n%\tO\nof\tO\npatients\tO\nwithdrawn\tO\nfrom\tO\ntreatment\tO\nbecause\tO\nof\tO\nclinical\tO\nadverse\tO\nexperiences\tO\n.\tO\n\nOphthalmological\tO\nexaminations\tO\nin\tO\nover\tO\n1100\tO\npatients\tO\ntreated\tO\nwith\tO\none\tO\nor\tO\nthe\tO\nother\tO\nagent\tO\nhave\tO\nrevealed\tO\nno\tO\nevidence\tO\nof\tO\nsignificant\tO\nshort\tO\nterm\tO\n(\tO\nup\tO\nto\tO\n2\tO\nyears\tO\n)\tO\ncataractogenic\tO\npotential\tO\n.\tO\n\nOne\tO\nto\tO\n2\tO\n%\tO\nof\tO\npatients\tO\nhave\tO\nelevations\tO\nof\tO\nserum\tO\ntransaminases\tO\nto\tO\ngreater\tO\nthan\tO\n3\tO\ntimes\tO\nthe\tO\nupper\tO\nlimit\tO\nof\tO\nnormal\tO\n.\tO\n\nThese\tO\nepisodes\tO\nare\tO\nasymptomatic\tO\nand\tO\nreversible\tO\nwhen\tO\ntherapy\tO\nis\tO\ndiscontinued\tO\n.\tO\n\nMinor\tO\nelevations\tO\nof\tO\ncreatine\tB-Chemical\nkinase\tO\nlevels\tO\nare\tO\nreported\tO\nin\tO\nabout\tO\n5\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nMyopathy\tB-Disease\n,\tO\nassociated\tO\nin\tO\nsome\tO\ncases\tO\nwith\tO\nmyoglobinuria\tB-Disease\n,\tO\nand\tO\nin\tO\n2\tO\ncases\tO\nwith\tO\ntransient\tO\nrenal\tB-Disease\nfailure\tI-Disease\n,\tO\nhas\tO\nbeen\tO\nrarely\tO\nreported\tO\nwith\tO\nlovastatin\tB-Chemical\n,\tO\nespecially\tO\nin\tO\npatients\tO\nconcomitantly\tO\ntreated\tO\nwith\tO\ncyclosporin\tB-Chemical\n,\tO\ngemfibrozil\tB-Chemical\nor\tO\nniacin\tB-Chemical\n.\tO\n\nLovastatin\tB-Chemical\nand\tO\nsimvastatin\tB-Chemical\nare\tO\nboth\tO\neffective\tO\nand\tO\nwell\tO\n-\tO\ntolerated\tO\nagents\tO\nfor\tO\nlowering\tO\nelevated\tO\nlevels\tO\nof\tO\nserum\tO\ncholesterol\tB-Chemical\n.\tO\n\nAs\tO\nwider\tO\nuse\tO\nconfirms\tO\ntheir\tO\nsafety\tO\nprofile\tO\n,\tO\nthey\tO\nwill\tO\ngain\tO\nincreasing\tO\nimportance\tO\nin\tO\nthe\tO\ntherapeutic\tO\napproach\tO\nto\tO\nhypercholesterolaemia\tB-Disease\nand\tO\nits\tO\nconsequences\tO\n.\tO\n\nHepatic\tO\nreactions\tO\nassociated\tO\nwith\tO\nketoconazole\tB-Chemical\nin\tO\nthe\tO\nUnited\tO\nKingdom\tO\n.\tO\n\nKetoconazole\tB-Chemical\nwas\tO\nintroduced\tO\nin\tO\nthe\tO\nUnited\tO\nKingdom\tO\nin\tO\n1981\tO\n.\tO\n\nBy\tO\nNovember\tO\n1984\tO\nthe\tO\nCommittee\tO\non\tO\nSafety\tO\nof\tO\nMedicines\tO\nhad\tO\nreceived\tO\n82\tO\nreports\tO\nof\tO\npossible\tO\nhepatotoxicity\tB-Disease\nassociated\tO\nwith\tO\nthe\tO\ndrug\tO\n,\tO\nincluding\tO\nfive\tO\ndeaths\tB-Disease\n.\tO\n\nAn\tO\nanalysis\tO\nof\tO\nthe\tO\n75\tO\ncases\tO\nthat\tO\nhad\tO\nbeen\tO\nadequately\tO\nfollowed\tO\nup\tO\nsuggested\tO\nthat\tO\n16\tO\n,\tO\nincluding\tO\nthree\tO\ndeaths\tB-Disease\n,\tO\nwere\tO\nprobably\tO\nrelated\tO\nto\tO\ntreatment\tO\nwith\tO\nthe\tO\ndrug\tO\n.\tO\n\nOf\tO\nthe\tO\nremainder\tO\n,\tO\n48\tO\nwere\tO\npossibly\tO\nrelated\tO\nto\tO\ntreatment\tO\n,\tO\nfive\tO\nwere\tO\nunlikely\tO\nto\tO\nbe\tO\nso\tO\n,\tO\nand\tO\nsix\tO\nwere\tO\nunclassifiable\tO\n.\tO\n\nThe\tO\nmean\tO\nage\tO\nof\tO\npatients\tO\nin\tO\nthe\tO\n16\tO\nprobable\tO\ncases\tO\nwas\tO\n57\tO\n.\tO\n9\tO\n,\tO\nwith\tO\nhepatotoxicity\tB-Disease\nbeing\tO\nmore\tO\ncommon\tO\nin\tO\nwomen\tO\n.\tO\n\nThe\tO\naverage\tO\nduration\tO\nof\tO\ntreatment\tO\nbefore\tO\nthe\tO\nonset\tO\nof\tO\njaundice\tB-Disease\nwas\tO\n61\tO\ndays\tO\n.\tO\n\nNone\tO\nof\tO\nthese\tO\nwell\tO\nvalidated\tO\ncases\tO\noccurred\tO\nwithin\tO\nthe\tO\nfirst\tO\n10\tO\ndays\tO\nafter\tO\ntreatment\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nserum\tO\nliver\tO\nfunction\tO\ntests\tO\nsuggested\tO\nhepatocellular\tB-Disease\ninjury\tI-Disease\nin\tO\n10\tO\n(\tO\n63\tO\n%\tO\n)\tO\n;\tO\nthe\tO\nrest\tO\nshowed\tO\na\tO\nmixed\tO\npattern\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nthe\tO\nresults\tO\nof\tO\nhistological\tO\nexamination\tO\nof\tO\nthe\tO\nliver\tO\noften\tO\nshowed\tO\nevidence\tO\nof\tO\ncholestasis\tB-Disease\n.\tO\n\nThe\tO\ncharacteristics\tO\nof\tO\nthe\tO\n48\tO\npatients\tO\nin\tO\nthe\tO\npossible\tO\ncases\tO\nwere\tO\nsimilar\tO\n.\tO\n\nAllergic\tO\nmanifestations\tO\nsuch\tO\nas\tO\nrash\tB-Disease\nand\tO\neosinophilia\tB-Disease\nwere\tO\nrare\tO\n.\tO\n\nHepatitis\tB-Disease\nwas\tO\nusually\tO\nreversible\tO\nwhen\tO\ntreatment\tO\nwas\tO\nstopped\tO\n,\tO\nwith\tO\nthe\tO\nresults\tO\nof\tO\nliver\tO\nfunction\tO\ntests\tO\nreturning\tO\nto\tO\nnormal\tO\nafter\tO\nan\tO\naverage\tO\nof\tO\n3\tO\n.\tO\n1\tO\nmonths\tO\n.\tO\n\nIn\tO\ntwo\tO\nof\tO\nthe\tO\nthree\tO\ndeaths\tB-Disease\nprobably\tO\nassociated\tO\nwith\tO\nketoconazole\tB-Chemical\ntreatment\tO\nthe\tO\ndrug\tO\nhad\tO\nbeen\tO\ncontinued\tO\nafter\tO\nthe\tO\nonset\tO\nof\tO\njaundice\tB-Disease\nand\tO\nother\tO\nsymptoms\tO\nof\tO\nhepatitis\tB-Disease\n.\tO\n\nClinical\tO\nand\tO\nbiochemical\tO\nmonitoring\tO\nat\tO\nregular\tO\nintervals\tO\nfor\tO\nevidence\tO\nof\tO\nhepatitis\tB-Disease\nis\tO\nadvised\tO\nduring\tO\nlong\tO\nterm\tO\ntreatment\tO\nwith\tO\nketoconazole\tB-Chemical\nto\tO\nprevent\tO\npossible\tO\nserious\tO\nhepatic\tB-Disease\ninjury\tI-Disease\n.\tO\n\nGlyburide\tB-Chemical\n-\tO\ninduced\tO\nhepatitis\tB-Disease\n.\tO\n\nDrug\tO\n-\tO\ninduced\tO\nhepatotoxicity\tB-Disease\n,\tO\nalthough\tO\ncommon\tO\n,\tO\nhas\tO\nbeen\tO\nreported\tO\nonly\tO\ninfrequently\tO\nwith\tO\nsulfonylureas\tB-Chemical\n.\tO\n\nFor\tO\nglyburide\tB-Chemical\n,\tO\na\tO\nsecond\tO\n-\tO\ngeneration\tO\nsulfonylurea\tB-Chemical\n,\tO\nonly\tO\ntwo\tO\nbrief\tO\nreports\tO\nof\tO\nhepatotoxicity\tB-Disease\nexist\tO\n.\tO\n\nTwo\tO\npatients\tO\nwith\tO\ntype\tB-Disease\nII\tI-Disease\ndiabetes\tI-Disease\nmellitus\tI-Disease\ndeveloped\tO\nan\tO\nacute\tB-Disease\nhepatitis\tI-Disease\n-\tI-Disease\nlike\tI-Disease\nsyndrome\tI-Disease\nsoon\tO\nafter\tO\ninitiation\tO\nof\tO\nglyburide\tB-Chemical\ntherapy\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nserologic\tO\nevidence\tO\nof\tO\nviral\tB-Disease\ninfection\tI-Disease\n,\tO\nand\tO\na\tO\nliver\tO\nbiopsy\tO\nsample\tO\nshowed\tO\na\tO\nhistologic\tO\npattern\tO\nconsistent\tO\nwith\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nhepatitis\tI-Disease\n.\tO\n\nBoth\tO\npatients\tO\nrecovered\tO\nquickly\tO\nafter\tO\nstopping\tO\nglyburide\tB-Chemical\ntherapy\tO\nand\tO\nhave\tO\nremained\tO\nwell\tO\nfor\tO\na\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\nof\tO\n1\tO\nyear\tO\n.\tO\n\nGlyburide\tB-Chemical\ncan\tO\nproduce\tO\nan\tO\nacute\tB-Disease\nhepatitis\tI-Disease\n-\tI-Disease\nlike\tI-Disease\nillness\tI-Disease\nin\tO\nsome\tO\npersons\tO\n.\tO\n\nIntracranial\tO\npressure\tO\nincreases\tO\nduring\tO\nalfentanil\tB-Chemical\n-\tO\ninduced\tO\nrigidity\tB-Disease\n.\tO\n\nIntracranial\tO\npressure\tO\n(\tO\nICP\tO\n)\tO\nwas\tO\nmeasured\tO\nduring\tO\nalfentanil\tB-Chemical\n-\tO\ninduced\tO\nrigidity\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nTen\tO\nrats\tO\nhad\tO\narterial\tO\n,\tO\ncentral\tO\nvenous\tO\n(\tO\nCVP\tO\n)\tO\n,\tO\nand\tO\nsubdural\tO\ncannulae\tO\ninserted\tO\nunder\tO\nhalothane\tB-Chemical\nanesthesia\tO\n.\tO\n\nThe\tO\nanimals\tO\nwere\tO\nmechanically\tO\nventilated\tO\nto\tO\nachieve\tO\nnormocarbia\tO\n(\tO\nPCO2\tO\n=\tO\n42\tO\n+\tO\n/\tO\n-\tO\n1\tO\nmmHg\tO\n,\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n.\tO\n\nFollowing\tO\ninstrumentation\tO\n,\tO\nhalothane\tB-Chemical\nwas\tO\ndiscontinued\tO\nand\tO\nalfentanil\tB-Chemical\n(\tO\n125\tO\nmu\tO\n/\tO\nkg\tO\n)\tO\nadministered\tO\niv\tO\nduring\tO\nemergence\tO\nfrom\tO\nhalothane\tB-Chemical\nanesthesia\tO\n.\tO\n\nIn\tO\nthe\tO\nfive\tO\nrats\tO\nthat\tO\ndeveloped\tO\nsomatic\tB-Disease\nrigidity\tI-Disease\n,\tO\nICP\tO\nand\tO\nCVP\tO\nincreased\tO\nsignificantly\tO\nabove\tO\nbaseline\tO\n(\tO\ndelta\tO\nICP\tO\n7\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n0\tO\nmmHg\tO\n,\tO\ndelta\tO\nCVP\tO\n5\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n1\tO\n.\tO\n3\tO\nmmHg\tO\n)\tO\n.\tO\n\nThese\tO\nvariables\tO\nreturned\tO\nto\tO\nbaseline\tO\nwhen\tO\nrigidity\tB-Disease\nwas\tO\nabolished\tO\nwith\tO\nmetocurine\tB-Chemical\n.\tO\n\nIn\tO\nfive\tO\nrats\tO\nthat\tO\ndid\tO\nnot\tO\nbecome\tO\nrigid\tO\n,\tO\nICP\tO\nand\tO\nCVP\tO\ndid\tO\nnot\tO\nchange\tO\nfollowing\tO\nalfentanil\tB-Chemical\n.\tO\n\nThese\tO\nobservations\tO\nsuggest\tO\nthat\tO\nrigidity\tB-Disease\nshould\tO\nbe\tO\nprevented\tO\nwhen\tO\nalfentanil\tB-Chemical\n,\tO\nand\tO\n,\tO\npresumably\tO\n,\tO\nother\tO\nopiates\tO\n,\tO\nare\tO\nused\tO\nin\tO\nthe\tO\nanesthetic\tO\nmanagement\tO\nof\tO\npatients\tO\nwith\tO\nICP\tO\nproblems\tO\n.\tO\n\nVerapamil\tB-Chemical\nwithdrawal\tO\nas\tO\na\tO\npossible\tO\ncause\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\na\tO\nhypertensive\tB-Disease\nwoman\tO\nwith\tO\na\tO\nnormal\tO\ncoronary\tO\nangiogram\tO\n.\tO\n\nVerapamil\tB-Chemical\nis\tO\nan\tO\neffective\tO\nand\tO\nrelatively\tO\n-\tO\nsafe\tO\nantihypertensive\tO\ndrug\tO\n.\tO\n\nSerious\tO\nadverse\tO\neffects\tO\nare\tO\nuncommon\tO\nand\tO\nmainly\tO\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nthe\tO\ndepression\tB-Disease\nof\tO\ncardiac\tO\ncontractility\tO\nand\tO\nconduction\tO\n,\tO\nespecially\tO\nwhen\tO\nthe\tO\ndrug\tO\nis\tO\ncombined\tO\nwith\tO\nbeta\tO\n-\tO\nblocking\tO\nagents\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nin\tO\nwhich\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\ncoincided\tO\nwith\tO\nthe\tO\nintroduction\tO\nof\tO\ncaptopril\tB-Chemical\nand\tO\nthe\tO\nwithdrawal\tO\nof\tO\nverapamil\tB-Chemical\nin\tO\na\tO\npreviously\tO\nasymptomatic\tO\nwoman\tO\nwith\tO\nsevere\tO\nhypertension\tB-Disease\n.\tO\n\nPossible\tO\nmechanisms\tO\nthat\tO\ninvolve\tO\na\tO\nverapamil\tB-Chemical\n-\tO\nrelated\tO\nincrease\tO\nin\tO\nplatelet\tO\nand\tO\n/\tO\nor\tO\nvascular\tO\nalpha\tO\n2\tO\n-\tO\nadrenoreceptor\tO\naffinity\tO\nfor\tO\ncatecholamines\tB-Chemical\nare\tO\ndiscussed\tO\n.\tO\n\nHaemolytic\tB-Disease\n-\tI-Disease\nuraemic\tI-Disease\nsyndrome\tI-Disease\nafter\tO\ntreatment\tO\nwith\tO\nmetronidazole\tB-Chemical\n.\tO\n\nThis\tO\npaper\tO\ndescribes\tO\nthe\tO\nclinical\tO\nfeatures\tO\nof\tO\nsix\tO\nchildren\tO\nwho\tO\ndeveloped\tO\nthe\tO\nhaemolytic\tB-Disease\n-\tI-Disease\nuraemic\tI-Disease\nsyndrome\tI-Disease\nafter\tO\ntreatment\tO\nwith\tO\nmetronidazole\tB-Chemical\n.\tO\n\nThese\tO\nchildren\tO\nwere\tO\nolder\tO\nand\tO\nwere\tO\nmore\tO\nlikely\tO\nto\tO\nhave\tO\nundergone\tO\nrecent\tO\nbowel\tO\nsurgery\tO\nthan\tO\nare\tO\nother\tO\nchildren\tO\nwith\tO\nthis\tO\ncondition\tO\n.\tO\n\nWhile\tO\nthe\tO\ninvolvement\tO\nof\tO\nmetronidazole\tB-Chemical\nin\tO\nthe\tO\naetiology\tO\nof\tO\nthe\tO\nhaemolytic\tB-Disease\n-\tI-Disease\nuraemic\tI-Disease\nsyndrome\tI-Disease\nis\tO\nnot\tO\nestablished\tO\nfirmly\tO\n,\tO\nthe\tO\naction\tO\nof\tO\nthis\tO\ndrug\tO\nin\tO\nsensitizing\tO\ntissues\tO\nto\tO\noxidation\tO\ninjury\tO\nand\tO\nthe\tO\nreported\tO\nevidence\tO\nof\tO\noxidation\tO\nchanges\tO\nin\tO\nthe\tO\nhaemolytic\tB-Disease\n-\tI-Disease\nuraemic\tI-Disease\nsyndrome\tI-Disease\nsuggest\tO\na\tO\npossible\tO\nlink\tO\nbetween\tO\nmetronidazole\tB-Chemical\ntreatment\tO\nand\tO\nsome\tO\ncases\tO\nof\tO\nthe\tO\nhaemolytic\tB-Disease\n-\tI-Disease\nuraemic\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nAdverse\tO\ncardiac\tO\neffects\tO\nduring\tO\ninduction\tO\nchemotherapy\tO\ntreatment\tO\nwith\tO\ncis\tB-Chemical\n-\tI-Chemical\nplatin\tI-Chemical\nand\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n.\tO\n\nSurvival\tO\nfor\tO\npatients\tO\nwith\tO\nadvanced\tO\nhead\tB-Disease\nand\tI-Disease\nneck\tI-Disease\ncarcinoma\tI-Disease\nand\tO\nesophageal\tB-Disease\ncarcinoma\tI-Disease\nis\tO\npoor\tO\nwith\tO\nradiotherapy\tO\nand\tO\n/\tO\nor\tO\nsurgery\tO\n.\tO\n\nObviously\tO\n,\tO\nthere\tO\nis\tO\na\tO\nneed\tO\nfor\tO\neffective\tO\nchemotherapy\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\ncis\tB-Chemical\n-\tI-Chemical\nplatin\tI-Chemical\n(\tO\n80\tO\n-\tO\n120\tO\nmg\tO\n/\tO\nm2BSA\tO\n)\tO\nand\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n(\tO\n1000\tO\nmg\tO\n/\tO\nm2BSA\tO\ndaily\tO\nas\tO\na\tO\ncontinuous\tO\ninfusion\tO\nduring\tO\n5\tO\ndays\tO\n)\tO\nwere\tO\ngiven\tO\nto\tO\n76\tO\npatients\tO\nbefore\tO\nradiotherapy\tO\nand\tO\nsurgery\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\nstudy\tO\nwas\tO\nto\tO\nclarify\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nadverse\tO\ncardiac\tO\neffects\tO\nto\tO\nthis\tO\ntreatment\tO\n.\tO\n\nBefore\tO\ntreatment\tO\nall\tO\npatients\tO\nhad\tO\na\tO\ncardiac\tO\nevaluation\tO\nand\tO\nduring\tO\ntreatment\tO\nserial\tO\nECG\tO\nrecordings\tO\nwere\tO\nperformed\tO\n.\tO\n\nIn\tO\nthe\tO\npre\tO\n-\tO\ntreatment\tO\nevaluation\tO\n,\tO\nsigns\tO\nof\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\nwere\tO\nfound\tO\nin\tO\n33\tO\npatients\tO\n(\tO\n43\tO\n%\tO\n)\tO\n.\tO\n\nDuring\tO\ntreatment\tO\n,\tO\nadverse\tO\ncardiac\tO\neffects\tO\nwere\tO\nobserved\tO\nin\tO\n14\tO\npatients\tO\n(\tO\n18\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmean\tO\nage\tO\nof\tO\nthese\tO\npatients\tO\nwas\tO\nthe\tO\nsame\tO\nas\tO\nfor\tO\nthe\tO\nentire\tO\ngroup\tO\n,\tO\n64\tO\nyears\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ncardiotoxicity\tB-Disease\nwas\tO\nnot\tO\nhigher\tO\nin\tO\npatients\tO\nwith\tO\nsigns\tO\nof\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\nthan\tO\nin\tO\nthose\tO\nwithout\tO\nin\tO\nthe\tO\npre\tO\n-\tO\ntreatment\tO\nevaluation\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nsigns\tO\nof\tO\ncardiotoxicity\tB-Disease\nwere\tO\nchest\tB-Disease\npain\tI-Disease\n,\tO\nST\tO\n-\tO\nT\tO\nwave\tO\nchanges\tO\nand\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n.\tO\n\nThis\tO\nwas\tO\nfollowed\tO\nby\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nin\tO\none\tO\npatient\tO\nand\tO\nsudden\tB-Disease\ndeath\tI-Disease\nin\tO\nanother\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\npatients\tO\non\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\ntreatment\tO\nshould\tO\nbe\tO\nunder\tO\nclose\tO\nsupervision\tO\nand\tO\nthat\tO\nthe\tO\ntreatment\tO\nshould\tO\nbe\tO\ndiscontinued\tO\nif\tO\nchest\tB-Disease\npain\tI-Disease\nor\tO\ntachyarrhythmia\tB-Disease\nis\tO\nobserved\tO\n.\tO\n\nDeath\tB-Disease\nfrom\tO\nchemotherapy\tO\nin\tO\ngestational\tB-Disease\ntrophoblastic\tI-Disease\ndisease\tI-Disease\n.\tO\n\nMultiple\tO\ncytotoxic\tO\ndrug\tO\nadministration\tO\nis\tO\nthe\tO\ngenerally\tO\naccepted\tO\ntreatment\tO\nof\tO\npatients\tO\nwith\tO\na\tO\nhigh\tO\n-\tO\nrisk\tO\nstage\tO\nof\tO\nchoriocarcinoma\tB-Disease\n.\tO\n\nBased\tO\non\tO\nthis\tO\nprinciple\tO\na\tO\n27\tO\n-\tO\nyear\tO\nold\tO\nwoman\tO\n,\tO\nclassified\tO\nas\tO\nbeing\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\nrisk\tO\ngroup\tO\n(\tO\nGoldstein\tO\nand\tO\nBerkowitz\tO\nscore\tO\n:\tO\n11\tO\n)\tO\n,\tO\nwas\tO\ntreated\tO\nwith\tO\nmultiple\tO\ncytotoxic\tO\ndrugs\tO\n.\tO\n\nThe\tO\nmultiple\tO\ndrug\tO\nschema\tO\nconsisted\tO\nof\tO\n:\tO\nEtoposide\tB-Chemical\n16\tO\n.\tO\n213\tO\n,\tO\nMethotrexate\tB-Chemical\n,\tO\nCyclophosphamide\tB-Chemical\n,\tO\nActomycin\tB-Chemical\n-\tI-Chemical\nD\tI-Chemical\n,\tO\nand\tO\nCisplatin\tB-Chemical\n.\tO\n\nOn\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\nthe\tO\nschedule\tO\n,\tO\nmoderate\tO\nhigh\tO\ndoses\tO\nof\tO\nMethotrexate\tB-Chemical\n,\tO\nEtoposide\tB-Chemical\nand\tO\nCyclophosphamide\tB-Chemical\nwere\tO\nadministered\tO\n.\tO\n\nWithin\tO\n8\tO\nhours\tO\nafter\tO\ninitiation\tO\nof\tO\ntherapy\tO\nthe\tO\npatient\tO\ndied\tO\nwith\tO\na\tO\nclinical\tO\npicture\tO\nresembling\tO\nmassive\tO\npulmonary\tB-Disease\nobstruction\tI-Disease\ndue\tO\nto\tO\nchoriocarcinomic\tO\ntissue\tO\nplugs\tO\n,\tO\nprobably\tO\noriginating\tO\nfrom\tO\nthe\tO\nuterus\tO\n.\tO\n\nFormation\tO\nof\tO\nthese\tO\nplugs\tO\nwas\tO\nprobably\tO\ndue\tO\nto\tO\nextensive\tO\ntumor\tB-Disease\nnecrosis\tB-Disease\nat\tO\nthe\tO\nlevel\tO\nof\tO\nthe\tO\nwalls\tO\nof\tO\nthe\tO\nmajor\tO\nuterine\tO\nveins\tO\n,\tO\nwhich\tO\nresulted\tO\nin\tO\nan\tO\nopen\tO\nexchange\tO\nof\tO\ntumor\tB-Disease\nplugs\tO\nto\tO\nthe\tO\nvascular\tO\nspaces\tO\n;\tO\ndecrease\tO\nin\tO\ntumor\tB-Disease\ntissue\tO\ncoherence\tO\nsecondary\tO\nto\tO\nchemotherapy\tO\nmay\tO\nhave\tO\nfurther\tO\ncontributed\tO\nto\tO\nthe\tO\nformation\tO\nof\tO\ntumor\tB-Disease\nemboli\tO\n.\tO\n\nIn\tO\nview\tO\nof\tO\nthe\tO\nclose\tO\ntime\tO\nassociation\tO\nbetween\tO\nthe\tO\nstart\tO\nof\tO\nchemotherapy\tO\nand\tO\nthe\tO\nacute\tO\nonset\tO\nof\tO\nmassive\tO\nembolism\tB-Disease\nother\tO\nexplanations\tO\n,\tO\nsuch\tO\nas\tO\nspontaneous\tO\nnecrosis\tB-Disease\n,\tO\nmust\tO\nbe\tO\nconsidered\tO\nless\tO\nlikely\tO\n.\tO\n\nPatients\tO\nwith\tO\nlarge\tO\npelvic\tB-Disease\ntumor\tI-Disease\nloads\tO\nare\tO\n,\tO\naccording\tO\nto\tO\nexisting\tO\nclassifications\tO\n,\tO\nat\tO\nhigh\tO\nrisk\tO\nto\tO\ndie\tO\nand\tO\nto\tO\ndevelop\tO\ndrug\tO\nresistance\tO\n.\tO\n\nNotwithstanding\tO\nthese\tO\nfacts\tO\nour\tO\nfindings\tO\nsuggest\tO\nthat\tO\nthese\tO\npatients\tO\nmight\tO\nbenefit\tO\nfrom\tO\nrelatively\tO\nmild\tO\ninitial\tO\ntreatment\tO\n,\tO\nespecially\tO\ntrue\tO\nfor\tO\npatients\tO\nnot\tO\npreviously\tO\nexposed\tO\nto\tO\nthis\tO\ndrug\tO\n.\tO\n\nClose\tO\nobservation\tO\nof\tO\nthe\tO\nresponse\tO\nstatus\tO\nboth\tO\nclinically\tO\nand\tO\nwith\tO\nbeta\tO\n-\tO\nhCG\tO\nvalues\tO\nmay\tO\nindicate\tO\nwhether\tO\nand\tO\nwhen\tO\nmore\tO\nagressive\tO\ncombination\tO\nchemotherapy\tO\nshould\tO\nbe\tO\nstarted\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nPulmonary\tO\nshunt\tO\nand\tO\ncardiovascular\tO\nresponses\tO\nto\tO\nCPAP\tO\nduring\tO\nnitroprusside\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ncontinuous\tO\npositive\tO\nairway\tO\npressure\tO\n(\tO\nCPAP\tO\n)\tO\non\tO\ncardiovascular\tO\ndynamics\tO\nand\tO\npulmonary\tO\nshunt\tO\n(\tO\nQS\tO\n/\tO\nQT\tO\n)\tO\nwere\tO\ninvestigated\tO\nin\tO\n12\tO\ndogs\tO\nbefore\tO\nand\tO\nduring\tO\nsodium\tB-Chemical\nnitroprusside\tI-Chemical\ninfusion\tO\nthat\tO\ndecreased\tO\nmean\tO\narterial\tO\nblood\tO\npressure\tO\n40\tO\n-\tO\n50\tO\nper\tO\ncent\tO\n.\tO\n\nBefore\tO\nnitroprusside\tB-Chemical\ninfusion\tO\n,\tO\n5\tO\ncm\tO\nH2O\tB-Chemical\nCPAP\tO\nsignificantly\tO\n,\tO\nP\tO\nless\tO\nthan\tO\n.\tO\n05\tO\n,\tO\ndecreased\tO\narterial\tO\nblood\tO\npressure\tO\n,\tO\nbut\tO\ndid\tO\nnot\tO\nsignificantly\tO\nalter\tO\nheart\tO\nrate\tO\n,\tO\ncardiac\tO\noutput\tO\n,\tO\nsystemic\tO\nvascular\tO\nresistance\tO\n,\tO\nor\tO\nQS\tO\n/\tO\nQT\tO\n.\tO\n\nTen\tO\ncm\tO\nH2O\tB-Chemical\nCPAP\tO\nbefore\tO\nnitroprusside\tB-Chemical\ninfusion\tO\nproduced\tO\na\tO\nfurther\tO\ndecrease\tB-Disease\nin\tI-Disease\narterial\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nand\tO\nsignificantly\tO\nincreased\tO\nheart\tO\nrate\tO\nand\tO\ndecreased\tB-Disease\ncardiac\tI-Disease\noutput\tI-Disease\nand\tO\nQS\tO\n/\tO\nQT\tO\n.\tO\n\nNitroprusside\tB-Chemical\ncaused\tO\nsignificant\tO\ndecreases\tB-Disease\nin\tI-Disease\narterial\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nand\tO\nsystemic\tO\nvascular\tO\nresistance\tO\nand\tO\nincreases\tO\nin\tO\nheart\tO\nrate\tO\n,\tO\nbut\tO\ndid\tO\nnot\tO\nchange\tO\ncardiac\tO\noutput\tO\nor\tO\nQS\tO\n/\tO\nQT\tO\n.\tO\n\nFive\tO\ncm\tO\nH2O\tB-Chemical\nCPAP\tO\nduring\tO\nnitroprusside\tB-Chemical\ndid\tO\nnot\tO\nfurther\tO\nalter\tO\nany\tO\nof\tO\nthe\tO\nabove\tO\n-\tO\nmentioned\tO\nvariables\tO\n.\tO\n\nHowever\tO\n,\tO\n10\tO\ncm\tO\nH2O\tB-Chemical\nCPAP\tO\ndecreased\tO\narterial\tO\nblood\tO\npressure\tO\n,\tO\ncardiac\tO\noutput\tO\n,\tO\nand\tO\nQS\tO\n/\tO\nQT\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nnitroprusside\tB-Chemical\ninfusion\tO\nrates\tO\nthat\tO\ndecrease\tO\nmean\tO\narterial\tO\nblood\tO\npressure\tO\nby\tO\n40\tO\n-\tO\n50\tO\nper\tO\ncent\tO\ndo\tO\nnot\tO\nchange\tO\ncardiac\tO\noutput\tO\nor\tO\nQS\tO\n/\tO\nQT\tO\n.\tO\n\nDuring\tO\nnitroprusside\tB-Chemical\ninfusion\tO\nlow\tO\nlevels\tO\nof\tO\nCPAP\tO\ndo\tO\nnot\tO\nmarkedly\tO\nalter\tO\ncardiovascular\tO\ndynamics\tO\n,\tO\nbut\tO\nhigh\tO\nlevels\tO\nof\tO\nCPAP\tO\n(\tO\n10\tO\ncm\tO\nH2O\tB-Chemical\n)\tO\n,\tO\nwhile\tO\ndecreasing\tO\nQS\tO\n/\tO\nQT\tO\n,\tO\nproduce\tO\nmarked\tO\ndecreases\tB-Disease\nin\tI-Disease\narterial\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nand\tI-Disease\ncardiac\tI-Disease\noutput\tI-Disease\n.\tO\n\nSystolic\tO\npressure\tO\nvariation\tO\nis\tO\ngreater\tO\nduring\tO\nhemorrhage\tB-Disease\nthan\tO\nduring\tO\nsodium\tB-Chemical\nnitroprusside\tI-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nin\tO\nventilated\tO\ndogs\tO\n.\tO\n\nThe\tO\nsystolic\tO\npressure\tO\nvariation\tO\n(\tO\nSPV\tO\n)\tO\n,\tO\nwhich\tO\nis\tO\nthe\tO\ndifference\tO\nbetween\tO\nthe\tO\nmaximal\tO\nand\tO\nminimal\tO\nvalues\tO\nof\tO\nthe\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\nSBP\tO\n)\tO\nafter\tO\none\tO\npositive\tO\n-\tO\npressure\tO\nbreath\tO\n,\tO\nwas\tO\nstudied\tO\nin\tO\nventilated\tO\ndogs\tO\nsubjected\tO\nto\tO\nhypotension\tB-Disease\n.\tO\n\nMean\tO\narterial\tO\npressure\tO\nwas\tO\ndecreased\tO\nto\tO\n50\tO\nmm\tO\nHg\tO\nfor\tO\n30\tO\nminutes\tO\neither\tO\nby\tO\nhemorrhage\tB-Disease\n(\tO\nHEM\tB-Disease\n,\tO\nn\tO\n=\tO\n7\tO\n)\tO\nor\tO\nby\tO\ncontinuous\tO\ninfusion\tO\nof\tO\nsodium\tB-Chemical\nnitroprusside\tI-Chemical\n(\tO\nSNP\tB-Chemical\n,\tO\nn\tO\n=\tO\n7\tO\n)\tO\n.\tO\n\nDuring\tO\nHEM\tB-Disease\n-\tO\ninduced\tO\nhypotension\tB-Disease\nthe\tO\ncardiac\tO\noutput\tO\nwas\tO\nsignificantly\tO\nlower\tO\nand\tO\nsystemic\tO\nvascular\tO\nresistance\tO\nhigher\tO\ncompared\tO\nwith\tO\nthat\tO\nin\tO\nthe\tO\nSNP\tB-Chemical\ngroup\tO\n.\tO\n\nThe\tO\nsystemic\tO\n,\tO\ncentral\tO\nvenous\tO\n,\tO\npulmonary\tO\ncapillary\tO\nwedge\tO\npressures\tO\n,\tO\nand\tO\nheart\tO\nrates\tO\n,\tO\nwere\tO\nsimilar\tO\nin\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nAnalysis\tO\nof\tO\nthe\tO\nrespiratory\tO\nchanges\tO\nin\tO\nthe\tO\narterial\tO\npressure\tO\nwaveform\tO\nenabled\tO\ndifferentiation\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nThe\tO\nSPV\tO\nduring\tO\nhypotension\tB-Disease\nwas\tO\n15\tO\n.\tO\n7\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n7\tO\nmm\tO\nHg\tO\nin\tO\nthe\tO\nHEM\tB-Disease\ngroup\tO\n,\tO\ncompared\tO\nwith\tO\n9\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n0\tO\nmm\tO\nHg\tO\nin\tO\nthe\tO\nSNP\tB-Chemical\ngroup\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nThe\tO\ndelta\tO\ndown\tO\n,\tO\nwhich\tO\nis\tO\nthe\tO\nmeasure\tO\nof\tO\ndecrease\tO\nof\tO\nSBP\tO\nafter\tO\na\tO\nmechanical\tO\nbreath\tO\n,\tO\nwas\tO\n20\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n8\tO\n.\tO\n4\tO\nand\tO\n10\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n8\tO\nmm\tO\nHg\tO\nin\tO\nthe\tO\nHEM\tB-Disease\nand\tO\nSNP\tB-Chemical\ngroups\tO\n,\tO\nrespectively\tO\n,\tO\nduring\tO\nhypotension\tB-Disease\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nincreases\tO\nin\tO\nthe\tO\nSPV\tO\nand\tO\nthe\tO\ndelta\tO\ndown\tO\nare\tO\ncharacteristic\tO\nof\tO\na\tO\nhypotensive\tB-Disease\nstate\tO\ndue\tO\nto\tO\na\tO\npredominant\tO\ndecrease\tO\nin\tO\npreload\tO\n.\tO\n\nThey\tO\nare\tO\nthus\tO\nmore\tO\nimportant\tO\nduring\tO\nabsolute\tO\nhypovolemia\tB-Disease\nthan\tO\nduring\tO\ndeliberate\tO\nhypotension\tB-Disease\n.\tO\n\nVentricular\tB-Disease\ntachyarrhythmias\tI-Disease\nduring\tO\ncesarean\tO\nsection\tO\nafter\tO\nritodrine\tB-Chemical\ntherapy\tO\n:\tO\ninteraction\tO\nwith\tO\nanesthetics\tO\n.\tO\n\nThis\tO\ncase\tO\nillustrates\tO\nthat\tO\npatients\tO\nreceiving\tO\nritodrine\tB-Chemical\nfor\tO\npreterm\tB-Disease\nlabor\tI-Disease\nmay\tO\nrisk\tO\ninteractions\tO\nbetween\tO\nthe\tO\nresidual\tO\nbetamimetic\tO\neffects\tO\nof\tO\nritodrine\tB-Chemical\nand\tO\nthe\tO\neffects\tO\nof\tO\nanesthetics\tO\nduring\tO\ncesarean\tO\nsection\tO\n.\tO\n\nSuch\tO\ninteractions\tO\nmay\tO\nresult\tO\nin\tO\nserious\tO\ncardiovascular\tB-Disease\ncomplications\tI-Disease\neven\tO\nafter\tO\ncessation\tO\nof\tO\nan\tO\ninfusion\tO\nof\tO\nritodrine\tB-Chemical\n.\tO\n\nPreoperative\tO\nassessment\tO\nshould\tO\nfocus\tO\non\tO\ncardiovascular\tO\nstatus\tO\nand\tO\nserum\tO\npotassium\tB-Chemical\nlevel\tO\n.\tO\n\nDelaying\tO\ninduction\tO\nof\tO\nanesthesia\tO\nshould\tO\nbe\tO\nconsidered\tO\nwhenever\tO\npossible\tO\n.\tO\n\nCareful\tO\nfluid\tO\nadministration\tO\nand\tO\ncautious\tO\nuse\tO\nof\tO\ntitrated\tO\ndoses\tO\nof\tO\nephedrine\tB-Chemical\nare\tO\nadvised\tO\n.\tO\n\nAfter\tO\ndelivery\tO\nof\tO\nthe\tO\ninfant\tO\n,\tO\nthere\tO\nshould\tO\nbe\tO\nno\tO\ncontraindication\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\nan\tO\nalpha\tO\n-\tO\nadrenergic\tO\nvasopressor\tO\nsuch\tO\nas\tO\nphenylephrine\tB-Chemical\nto\tO\ntreat\tO\nhypotensive\tB-Disease\npatients\tO\nwith\tO\ntachycardia\tB-Disease\n.\tO\n\nVerapamil\tB-Chemical\n-\tO\ninduced\tO\ncarbamazepine\tB-Chemical\nneurotoxicity\tB-Disease\n.\tO\n\nA\tO\nreport\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nTwo\tO\npatients\tO\nwith\tO\nsigns\tO\nof\tO\ncarbamazepine\tB-Chemical\nneurotoxicity\tB-Disease\nafter\tO\ncombined\tO\ntreatment\tO\nwith\tO\nverapamil\tB-Chemical\nshowed\tO\ncomplete\tO\nrecovery\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ncalcium\tB-Chemical\nentry\tO\nblocker\tO\n.\tO\n\nUse\tO\nof\tO\nverapamil\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\ncarbamazepine\tB-Chemical\nshould\tO\neither\tO\nbe\tO\navoided\tO\nor\tO\nprescribed\tO\nonly\tO\nwith\tO\nappropriate\tO\nadjustment\tO\nof\tO\nthe\tO\ncarbamazepine\tB-Chemical\ndose\tO\n(\tO\nusually\tO\nreduction\tO\nof\tO\nthe\tO\ncarbamazepine\tB-Chemical\ndose\tO\nby\tO\none\tO\nhalf\tO\n)\tO\n.\tO\n\nParacetamol\tB-Chemical\n-\tO\nassociated\tO\ncoma\tB-Disease\n,\tO\nmetabolic\tB-Disease\nacidosis\tI-Disease\n,\tO\nrenal\tB-Disease\nand\tI-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\n.\tO\n\nA\tO\ncase\tO\nof\tO\nmetabolic\tB-Disease\nacidosis\tI-Disease\n,\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nand\tI-Disease\nhepatic\tI-Disease\nfailure\tI-Disease\nfollowing\tO\nparacetamol\tB-Chemical\ningestion\tO\nis\tO\npresented\tO\n.\tO\n\nThe\tO\ndiagnostic\tO\ndifficulty\tO\nat\tO\npresentation\tO\nis\tO\nhighlighted\tO\n.\tO\n\nContinuous\tO\narteriovenous\tO\nhaemofiltration\tO\nproved\tO\na\tO\nvaluable\tO\nmeans\tO\nof\tO\nmaintaining\tO\nfluid\tO\nand\tO\nelectrolyte\tO\nbalance\tO\n.\tO\n\nThe\tO\npatient\tO\nrecovered\tO\n.\tO\n\nSexual\tB-Disease\ndysfunction\tI-Disease\namong\tO\npatients\tO\nwith\tO\narthritis\tB-Disease\n.\tO\n\nThe\tO\nrelationship\tO\nof\tO\narthritis\tB-Disease\nand\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\nwas\tO\ninvestigated\tO\namong\tO\n169\tO\npatients\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n,\tO\nosteoarthritis\tB-Disease\nand\tO\nspondyloarthropathy\tB-Disease\n,\tO\n130\tO\nof\tO\nwhom\tO\nwere\tO\npair\tO\n-\tO\nmatched\tO\nto\tO\ncontrols\tO\n.\tO\n\nAssessments\tO\nof\tO\nmarital\tO\nhappiness\tO\nand\tO\ndepressed\tB-Disease\nmood\tI-Disease\nwere\tO\nalso\tO\nmade\tO\nusing\tO\nthe\tO\nCES\tO\n-\tO\nD\tO\nand\tO\nthe\tO\nAzrin\tO\nMarital\tO\nHappiness\tO\nScale\tO\n(\tO\nAMHS\tO\n)\tO\n.\tO\n\nSexual\tB-Disease\ndysfunctions\tI-Disease\nwere\tO\nfound\tO\nto\tO\nbe\tO\ncommon\tO\namong\tO\npatients\tO\nand\tO\ncontrols\tO\n,\tO\nthe\tO\nmajority\tO\nin\tO\nboth\tO\ngroups\tO\nreporting\tO\none\tO\nor\tO\nmore\tO\ndysfunctions\tO\n.\tO\n\nImpotence\tB-Disease\nwas\tO\nmore\tO\ncommon\tO\namong\tO\nmale\tO\npatients\tO\nthan\tO\ncontrols\tO\nand\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nco\tO\n-\tO\nmorbidity\tO\nand\tO\nthe\tO\ntaking\tO\nof\tO\nmethotrexate\tB-Chemical\n.\tO\n\nDepressed\tB-Disease\nmood\tI-Disease\nwas\tO\nmore\tO\ncommon\tO\namong\tO\npatients\tO\nand\tO\nwas\tO\nassociated\tO\nwith\tO\ncertain\tO\nsexual\tO\ndifficulties\tO\n,\tO\nbut\tO\nnot\tO\nwith\tO\nimpotence\tB-Disease\n.\tO\n\nMarital\tO\nunhappiness\tO\n,\tO\nas\tO\nindicated\tO\nby\tO\nAMHS\tO\nscores\tO\n,\tO\nwas\tO\nnot\tO\nassociated\tO\nwith\tO\narthritis\tB-Disease\nbut\tO\nwas\tO\nassociated\tO\nwith\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\n,\tO\nsexual\tO\ndissatisfaction\tO\nand\tO\nbeing\tO\nfemale\tO\n.\tO\n\nDoes\tO\nparacetamol\tB-Chemical\ncause\tO\nurothelial\tB-Disease\ncancer\tI-Disease\nor\tO\nrenal\tB-Disease\npapillary\tI-Disease\nnecrosis\tI-Disease\n?\tO\n\nThe\tO\nrisk\tO\nof\tO\ndeveloping\tO\nrenal\tB-Disease\npapillary\tI-Disease\nnecrosis\tI-Disease\nor\tO\ncancer\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nrenal\tI-Disease\npelvis\tI-Disease\n,\tI-Disease\nureter\tI-Disease\nor\tI-Disease\nbladder\tI-Disease\nassociated\tO\nwith\tO\nconsumption\tO\nof\tO\neither\tO\nphenacetin\tB-Chemical\nor\tO\nparacetamol\tB-Chemical\nwas\tO\ncalculated\tO\nfrom\tO\ndata\tO\nacquired\tO\nby\tO\nquestionnaire\tO\nfrom\tO\n381\tO\ncases\tO\nand\tO\n808\tO\ncontrols\tO\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nrenal\tB-Disease\npapillary\tI-Disease\nnecrosis\tI-Disease\nwas\tO\nincreased\tO\nnearly\tO\n20\tO\n-\tO\nfold\tO\nby\tO\nconsumption\tO\nof\tO\nphenacetin\tB-Chemical\n,\tO\nwhich\tO\nalso\tO\nincreased\tO\nthe\tO\nrisk\tO\nfor\tO\ncancer\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nrenal\tI-Disease\npelvis\tI-Disease\nand\tI-Disease\nbladder\tI-Disease\nbut\tO\nnot\tO\nfor\tO\nureteric\tB-Disease\ncancer\tI-Disease\n.\tO\n\nBy\tO\ncontrast\tO\n,\tO\nwe\tO\nwere\tO\nunable\tO\nto\tO\nsubstantiate\tO\nan\tO\nincreased\tO\nrisk\tO\nfrom\tO\nparacetamol\tB-Chemical\nconsumption\tO\nfor\tO\nrenal\tB-Disease\npapillary\tI-Disease\nnecrosis\tI-Disease\nor\tO\nany\tO\nof\tO\nthese\tO\ncancers\tB-Disease\nalthough\tO\nthere\tO\nwas\tO\na\tO\nsuggestion\tO\nof\tO\nan\tO\nassociation\tO\nwith\tO\ncancer\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nureter\tI-Disease\n.\tO\n\nDapsone\tB-Chemical\n-\tO\nassociated\tO\nHeinz\tO\nbody\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nin\tO\na\tO\nCambodian\tO\nwoman\tO\nwith\tO\nhemoglobin\tO\nE\tO\ntrait\tO\n.\tO\n\nA\tO\nCambodian\tO\nwoman\tO\nwith\tO\nhemoglobin\tO\nE\tO\ntrait\tO\n(\tO\nAE\tO\n)\tO\nand\tO\nleprosy\tB-Disease\ndeveloped\tO\na\tO\nHeinz\tO\nbody\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nwhile\tO\ntaking\tO\na\tO\ndose\tO\nof\tO\ndapsone\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\nday\tO\n)\tO\nnot\tO\nusually\tO\nassociated\tO\nwith\tO\nclinical\tO\nhemolysis\tB-Disease\n.\tO\n\nHer\tO\nred\tO\nblood\tO\ncells\tO\n(\tO\nRBCs\tO\n)\tO\nhad\tO\nincreased\tO\nincubated\tO\nHeinz\tO\nbody\tO\nformation\tO\n,\tO\ndecreased\tO\nreduced\tO\nglutathione\tB-Chemical\n(\tO\nGSH\tB-Chemical\n)\tO\n,\tO\nand\tO\ndecreased\tO\nGSH\tB-Chemical\nstability\tO\n.\tO\n\nThe\tO\npentose\tB-Chemical\nphosphate\tI-Chemical\nshunt\tO\nactivity\tO\nof\tO\nthe\tO\ndapsone\tB-Chemical\n-\tO\nexposed\tO\nAE\tO\nRBCs\tO\nwas\tO\nincreased\tO\ncompared\tO\nto\tO\nnormal\tO\nRBCs\tO\n.\tO\n\nAlthough\tO\nthe\tO\nAE\tO\nRBCs\tO\nfrom\tO\nan\tO\nindividual\tO\nnot\tO\ntaking\tO\ndapsone\tB-Chemical\nhad\tO\nincreased\tO\nincubated\tO\nHeinz\tO\nbody\tO\nformation\tO\n,\tO\nthe\tO\nGSH\tB-Chemical\ncontent\tO\nand\tO\nGSH\tB-Chemical\nstability\tO\nwere\tO\nnormal\tO\n.\tO\n\nThe\tO\npentose\tB-Chemical\nphosphate\tI-Chemical\nshunt\tO\nactivity\tO\nof\tO\nthe\tO\nnon\tO\n-\tO\ndapsone\tB-Chemical\n-\tO\nexposed\tO\nAE\tO\nRBCs\tO\nwas\tO\ndecreased\tO\ncompared\tO\nto\tO\nnormal\tO\nRBCs\tO\n.\tO\n\nThus\tO\n,\tO\nAE\tO\nRBCs\tO\nappear\tO\nto\tO\nhave\tO\nan\tO\nincreased\tO\nsensitivity\tO\nto\tO\noxidant\tO\nstress\tO\nboth\tO\nin\tO\nvitro\tO\nand\tO\nin\tO\nvivo\tO\n,\tO\nsince\tO\ndapsone\tB-Chemical\ndoes\tO\nnot\tO\ncause\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nat\tO\nthis\tO\ndose\tO\nin\tO\nhematologically\tO\nnormal\tO\nindividuals\tO\n.\tO\n\nGiven\tO\nthe\tO\ninflux\tO\nof\tO\nSoutheast\tO\nAsians\tO\ninto\tO\nthe\tO\nUnited\tO\nStates\tO\n,\tO\noxidant\tO\nmedications\tO\nshould\tO\nbe\tO\nused\tO\nwith\tO\ncaution\tO\n,\tO\nespecially\tO\nif\tO\nan\tO\ninfection\tB-Disease\nis\tO\npresent\tO\n,\tO\nin\tO\nindividuals\tO\nof\tO\nethnic\tO\nbackgrounds\tO\nthat\tO\nhave\tO\nan\tO\nincreased\tO\nprevalence\tO\nof\tO\nhemoglobin\tO\nE\tO\n.\tO\n\nSevere\tO\ncomplications\tO\nof\tO\nantianginal\tO\ndrug\tO\ntherapy\tO\nin\tO\na\tO\npatient\tO\nidentified\tO\nas\tO\na\tO\npoor\tO\nmetabolizer\tO\nof\tO\nmetoprolol\tB-Chemical\n,\tO\npropafenone\tB-Chemical\n,\tO\ndiltiazem\tB-Chemical\n,\tO\nand\tO\nsparteine\tB-Chemical\n.\tO\n\nA\tO\n47\tO\n-\tO\nyear\tO\n-\tO\nold\tO\npatient\tO\nsuffering\tO\nfrom\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nwas\tO\nadmitted\tO\nto\tO\nthe\tO\nCCU\tO\nin\tO\nshock\tB-Disease\nwith\tO\nIII\tO\n.\tO\n\nAV\tB-Disease\nblock\tI-Disease\n,\tO\nsevere\tO\nhypotension\tB-Disease\n,\tO\nand\tO\nimpairment\tB-Disease\nof\tI-Disease\nventricular\tI-Disease\nfunction\tI-Disease\n.\tO\n\nOne\tO\nweek\tO\nprior\tO\nto\tO\nadmission\tO\na\tO\ntherapy\tO\nwith\tO\nstandard\tO\ndoses\tO\nof\tO\nmetoprolol\tB-Chemical\n(\tO\n100\tO\nmg\tO\nt\tO\n.\tO\ni\tO\n.\tO\nd\tO\n.\tO\nand\tO\nthen\tO\n100\tO\nmg\tO\nb\tO\n.\tO\ni\tO\n.\tO\nd\tO\n.\tO\n)\tO\nhad\tO\nbeen\tO\ninitiated\tO\n.\tO\n\nTwo\tO\ndays\tO\nbefore\tO\nadmission\tO\ndiltiazem\tB-Chemical\n(\tO\n60\tO\nmg\tO\nb\tO\n.\tO\ni\tO\n.\tO\nd\tO\n.\tO\n)\tO\nwas\tO\nprescribed\tO\nin\tO\naddition\tO\n.\tO\n\nAnalyses\tO\nof\tO\na\tO\nblood\tO\nsample\tO\nrevealed\tO\nunusually\tO\nhigh\tO\nplasma\tO\nconcentrations\tO\nof\tO\nmetoprolol\tB-Chemical\n(\tO\ngreater\tO\nthan\tO\n3000\tO\nng\tO\n/\tO\nml\tO\n)\tO\nand\tO\ndiltiazem\tB-Chemical\n(\tO\n526\tO\nng\tO\n/\tO\nml\tO\n)\tO\n.\tO\n\nThe\tO\npatient\tO\nrecovered\tO\nwithin\tO\n1\tO\nweek\tO\nfollowing\tO\ndiscontinuation\tO\nof\tO\nantianginal\tO\ntherapy\tO\n.\tO\n\nThree\tO\nmonths\tO\nlater\tO\nthe\tO\npatient\tO\nwas\tO\nexposed\tO\nto\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nmetoprolol\tB-Chemical\n,\tO\ndiltiazem\tB-Chemical\n,\tO\npropafenone\tB-Chemical\n(\tO\nsince\tO\nhe\tO\nhad\tO\nreceived\tO\nthis\tO\ndrug\tO\nin\tO\nthe\tO\npast\tO\n)\tO\n,\tO\nand\tO\nsparteine\tB-Chemical\n(\tO\nas\tO\na\tO\nprobe\tO\nfor\tO\nthe\tO\ndebrisoquine\tB-Chemical\n/\tO\nsparteine\tB-Chemical\ntype\tO\npolymorphism\tO\nof\tO\noxidative\tO\ndrug\tO\nmetabolism\tO\n)\tO\n.\tO\n\nIt\tO\nwas\tO\nfound\tO\nthat\tO\nhe\tO\nwas\tO\na\tO\npoor\tO\nmetabolizer\tO\nof\tO\nall\tO\nfour\tO\ndrugs\tO\n,\tO\nindicating\tO\nthat\tO\ntheir\tO\nmetabolism\tO\nis\tO\nunder\tO\nthe\tO\nsame\tO\ngenetic\tO\ncontrol\tO\n.\tO\n\nTherefore\tO\n,\tO\npatients\tO\nbelonging\tO\nto\tO\nthe\tO\npoor\tO\n-\tO\nmetabolizer\tO\nphenotype\tO\nof\tO\nsparteine\tB-Chemical\n/\tO\ndebrisoquine\tB-Chemical\npolymorphism\tO\nin\tO\ndrug\tO\nmetabolism\tO\n,\tO\nwhich\tO\nconstitutes\tO\n6\tO\n.\tO\n4\tO\n%\tO\nof\tO\nthe\tO\nGerman\tO\npopulation\tO\n,\tO\nmay\tO\nexperience\tO\nadverse\tB-Disease\ndrug\tI-Disease\nreactions\tI-Disease\nwhen\tO\ntreated\tO\nwith\tO\nstandard\tO\ndoses\tO\nof\tO\none\tO\nof\tO\nthese\tO\ndrugs\tO\nalone\tO\n.\tO\n\nMoreover\tO\n,\tO\nthe\tO\ncoadministration\tO\nof\tO\nthese\tO\nfrequently\tO\nused\tO\ndrugs\tO\nis\tO\nexpected\tO\nto\tO\nbe\tO\nespecially\tO\nharmful\tO\nin\tO\nthis\tO\nsubgroup\tO\nof\tO\npatients\tO\n.\tO\n\nClinical\tO\nexperiences\tO\nin\tO\nan\tO\nopen\tO\nand\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\ntrial\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\nsixty\tO\npatients\tO\nwere\tO\ntrated\tO\nwith\tO\nbromperidol\tB-Chemical\nfirst\tO\nin\tO\nopen\tO\nconditions\tO\n(\tO\n20\tO\npatients\tO\n)\tO\n,\tO\nthen\tO\non\tO\na\tO\ndouble\tO\nblind\tO\nbasis\tO\n(\tO\n40\tO\npatients\tO\n)\tO\nwith\tO\nhaloperidol\tB-Chemical\nas\tO\nthe\tO\nreference\tO\nsubstance\tO\n.\tO\n\nThe\tO\nopen\tO\nstudy\tO\nlasted\tO\nfor\tO\nfour\tO\nweeks\tO\n;\tO\nthe\tO\ndrug\tO\nwas\tO\nadministrated\tO\nin\tO\nthe\tO\nform\tO\nof\tO\n1\tO\nmg\tO\ntablets\tO\n.\tO\n\nThe\tO\ndaily\tO\ndose\tO\n(\tO\ninitial\tO\ndose\tO\n:\tO\n1\tO\nmg\tO\n;\tO\nmean\tO\ndose\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\ntrial\tO\n:\tO\n4\tO\n.\tO\n47\tO\nmg\tO\n)\tO\nwas\tO\nalways\tO\nadministered\tO\nin\tO\none\tO\nsingle\tO\ndose\tO\n.\tO\n\nNineteen\tO\npatients\tO\nfinished\tO\nthe\tO\ntrial\tO\n,\tO\nand\tO\nin\tO\n18\tO\ncases\tO\nthe\tO\ntherapeutic\tO\nresult\tO\nwas\tO\nconsidered\tO\nvery\tO\ngood\tO\nto\tO\ngood\tO\n.\tO\n\nThese\tO\nresults\tO\nwere\tO\nconfirmed\tO\nby\tO\nstatistical\tO\nanalysis\tO\n.\tO\n\nNine\tO\npatients\tO\nexhibited\tO\nmild\tO\nto\tO\nmoderate\tO\nextrapyramidal\tB-Disease\nconcomitant\tI-Disease\nsymptoms\tI-Disease\n;\tO\nno\tO\nother\tO\nside\tO\neffects\tO\nwere\tO\nobserved\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\ndetailed\tO\nlaboratory\tO\ntests\tO\nand\tO\nevaluations\tO\nof\tO\nvarious\tO\nquantitative\tO\nand\tO\nqualitative\tO\ntolerability\tO\nparameters\tO\nwere\tO\nnot\tO\nindicative\tO\nof\tO\ntoxic\tO\neffects\tO\n.\tO\n\nIn\tO\nthe\tO\ndouble\tO\nblind\tO\nstudy\tO\nwith\tO\nhaloperidol\tB-Chemical\n,\tO\nboth\tO\nsubstances\tO\nwere\tO\nfound\tO\nto\tO\nbe\tO\nhighly\tO\neffective\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\npsychotic\tB-Disease\nsyndromes\tI-Disease\nbelonging\tI-Disease\npredominantly\tI-Disease\nto\tI-Disease\nthe\tI-Disease\nschizophrenia\tI-Disease\ngroup\tI-Disease\n.\tO\n\nCertain\tO\nclues\tO\n,\tO\nincluding\tO\nthe\tO\nonset\tO\nof\tO\naction\tO\n,\tO\nseem\tO\nto\tO\nbe\tO\nindicative\tO\nof\tO\nthe\tO\nsuperiority\tO\nof\tO\nbromperidol\tB-Chemical\n.\tO\n\nNo\tO\ndifferences\tO\nwere\tO\nobserved\tO\nwith\tO\nrespect\tO\nto\tO\nside\tO\neffects\tO\nand\tO\ngeneral\tO\ntolerability\tO\n.\tO\n\nProlonged\tO\ncholestasis\tB-Disease\nafter\tO\ntroleandomycin\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\nhepatitis\tB-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\npatient\tO\nin\tO\nwhom\tO\ntroleandomycin\tB-Chemical\n-\tO\ninduced\tO\nhepatitis\tB-Disease\nwas\tO\nfollowed\tO\nby\tO\nprolonged\tO\nanicteric\tO\ncholestasis\tB-Disease\n.\tO\n\nJaundice\tB-Disease\noccurred\tO\nafter\tO\nadministration\tO\nof\tO\ntroleandomycin\tB-Chemical\nfor\tO\n7\tO\ndays\tO\nand\tO\nwas\tO\nassociated\tO\nwith\tO\nhypereosinophilia\tB-Disease\n.\tO\n\nJaundice\tB-Disease\ndisappeared\tO\nwithin\tO\n3\tO\nmonths\tO\nbut\tO\nwas\tO\nfollowed\tO\nby\tO\nprolonged\tO\nanicteric\tO\ncholestasis\tB-Disease\nmarked\tO\nby\tO\npruritus\tB-Disease\nand\tO\nhigh\tO\nlevels\tO\nof\tO\nalkaline\tO\nphosphatase\tO\nand\tO\ngammaglutamyltransferase\tO\nactivities\tO\n.\tO\n\nFinally\tO\n,\tO\npruritus\tB-Disease\ndisappeared\tO\nwithin\tO\n19\tO\nmonths\tO\n,\tO\nand\tO\nliver\tO\ntests\tO\nreturned\tO\nto\tO\nnormal\tO\n27\tO\nmonths\tO\nafter\tO\nthe\tO\nonset\tO\nof\tO\nhepatitis\tB-Disease\n.\tO\n\nThis\tO\nobservation\tO\ndemonstrates\tO\nthat\tO\nprolonged\tO\ncholestasis\tB-Disease\ncan\tO\nfollow\tO\ntroleandomycin\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\nhepatitis\tB-Disease\n.\tO\n\nSerial\tO\nstudies\tO\nof\tO\nauditory\tB-Disease\nneurotoxicity\tI-Disease\nin\tO\npatients\tO\nreceiving\tO\ndeferoxamine\tB-Chemical\ntherapy\tO\n.\tO\n\nVisual\tB-Disease\nand\tI-Disease\nauditory\tI-Disease\nneurotoxicity\tI-Disease\nwas\tO\npreviously\tO\ndocumented\tO\nin\tO\n42\tO\nof\tO\n89\tO\npatients\tO\nwith\tO\ntransfusion\tO\n-\tO\ndependent\tO\nanemia\tB-Disease\nwho\tO\nwere\tO\nreceiving\tO\niron\tB-Chemical\nchelation\tO\ntherapy\tO\nwith\tO\ndaily\tO\nsubcutaneous\tO\ndeferoxamine\tB-Chemical\n.\tO\n\nTwenty\tO\n-\tO\ntwo\tO\npatients\tO\nin\tO\nthe\tO\naffected\tO\ngroup\tO\nhad\tO\nabnormal\tB-Disease\naudiograms\tI-Disease\nwith\tI-Disease\ndeficits\tI-Disease\nmostly\tI-Disease\nin\tI-Disease\nthe\tI-Disease\nhigh\tI-Disease\nfrequency\tI-Disease\nrange\tI-Disease\nof\tI-Disease\n4\tI-Disease\n,\tI-Disease\n000\tI-Disease\nto\tI-Disease\n8\tI-Disease\n,\tI-Disease\n000\tI-Disease\nHz\tI-Disease\nand\tO\nin\tO\nthe\tO\nhearing\tO\nthreshold\tO\nlevels\tO\nof\tO\n30\tO\nto\tO\n100\tO\ndecibels\tO\n.\tO\n\nWhen\tO\ndeferoxamine\tB-Chemical\ntherapy\tO\nwas\tO\ndiscontinued\tO\nand\tO\nserial\tO\nstudies\tO\nwere\tO\nperformed\tO\n,\tO\naudiograms\tO\nin\tO\nseven\tO\ncases\tO\nreverted\tO\nto\tO\nnormal\tO\nor\tO\nnear\tO\nnormal\tO\nwithin\tO\ntwo\tO\nto\tO\nthree\tO\nweeks\tO\n,\tO\nand\tO\nnine\tO\nof\tO\n13\tO\npatients\tO\nwith\tO\nsymptoms\tO\nbecame\tO\nasymptomatic\tO\n.\tO\n\nAudiograms\tO\nfrom\tO\n15\tO\npatients\tO\nremained\tO\nabnormal\tO\nand\tO\nfour\tO\npatients\tO\nrequired\tO\nhearing\tO\naids\tO\nbecause\tO\nof\tO\npermanent\tB-Disease\ndisability\tI-Disease\n.\tO\n\nSince\tO\n18\tO\nof\tO\nthe\tO\n22\tO\npatients\tO\nwere\tO\ninitially\tO\nreceiving\tO\ndeferoxamine\tB-Chemical\ndoses\tO\nin\tO\nexcess\tO\nof\tO\nthe\tO\ncommonly\tO\nrecommended\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\ndose\tO\n,\tO\ntherapy\tO\nwas\tO\nrestarted\tO\nwith\tO\nlower\tO\ndoses\tO\n,\tO\nusually\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\ndose\tO\nor\tO\nless\tO\ndepending\tO\non\tO\nthe\tO\ndegree\tO\nof\tO\nauditory\tB-Disease\nabnormality\tI-Disease\n,\tO\nand\tO\nwith\tO\nthe\tO\nexception\tO\nof\tO\ntwo\tO\ncases\tO\nno\tO\nfurther\tO\ntoxicity\tB-Disease\nwas\tO\ndemonstrated\tO\n.\tO\n\nAuditory\tO\ndeterioration\tO\nand\tO\nimprovement\tO\n,\tO\ndemonstrated\tO\nserially\tO\nin\tO\nindividual\tO\npatients\tO\nreceiving\tO\nand\tO\nnot\tO\nreceiving\tO\ndeferoxamine\tB-Chemical\n,\tO\nrespectively\tO\n,\tO\nprovided\tO\nconvincing\tO\nevidence\tO\nfor\tO\na\tO\ncause\tO\n-\tO\nand\tO\n-\tO\neffect\tO\nrelation\tO\nbetween\tO\ndeferoxamine\tB-Chemical\nadministration\tO\nand\tO\nototoxicity\tB-Disease\n.\tO\n\nBased\tO\non\tO\nthese\tO\ndata\tO\n,\tO\na\tO\nplan\tO\nof\tO\nmanagement\tO\nwas\tO\ndeveloped\tO\nthat\tO\nallows\tO\neffective\tO\nyet\tO\nsafe\tO\nadministration\tO\nof\tO\ndeferoxamine\tB-Chemical\n.\tO\n\nA\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nis\tO\nrecommended\tO\nin\tO\nthose\tO\nwithout\tO\naudiogram\tO\nabnormalities\tO\n.\tO\n\nWith\tO\nmild\tO\ntoxicity\tB-Disease\n,\tO\na\tO\nreduction\tO\nto\tO\n30\tO\nor\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\ndose\tO\nshould\tO\nresult\tO\nin\tO\na\tO\nreversal\tO\nof\tO\nthe\tO\nabnormal\tO\nresults\tO\nto\tO\nnormal\tO\nwithin\tO\nfour\tO\nweeks\tO\n.\tO\n\nModerate\tO\nabnormalities\tO\nrequire\tO\na\tO\nreduction\tO\nof\tO\ndeferoxamine\tB-Chemical\nto\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\ndose\tO\nwith\tO\ncareful\tO\nmonitoring\tO\n.\tO\n\nIn\tO\nthose\tO\nwith\tO\nsymptoms\tO\nof\tO\nhearing\tB-Disease\nloss\tI-Disease\n,\tO\nthe\tO\ndrug\tO\nshould\tO\nbe\tO\nstopped\tO\nfor\tO\nfour\tO\nweeks\tO\n,\tO\nand\tO\nwhen\tO\nthe\tO\naudiogram\tO\nis\tO\nstable\tO\nor\tO\nimproved\tO\n,\tO\ntherapy\tO\nshould\tO\nbe\tO\nrestarted\tO\nat\tO\n10\tO\nto\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\ndose\tO\n.\tO\n\nSerial\tO\naudiograms\tO\nshould\tO\nbe\tO\nperformed\tO\nevery\tO\nsix\tO\nmonths\tO\nin\tO\nthose\tO\nwithout\tO\nproblems\tO\nand\tO\nmore\tO\nfrequently\tO\nin\tO\nyoung\tO\npatients\tO\nwith\tO\nnormal\tO\nserum\tO\nferritin\tO\nvalues\tO\nand\tO\nin\tO\nthose\tO\nwith\tO\nauditory\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nLidocaine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\nasystole\tI-Disease\n.\tO\n\nIntravenous\tO\nadministration\tO\nof\tO\na\tO\nsingle\tO\n50\tO\n-\tO\nmg\tO\nbolus\tO\nof\tO\nlidocaine\tB-Chemical\nin\tO\na\tO\n67\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nresulted\tO\nin\tO\nprofound\tO\ndepression\tB-Disease\nof\tO\nthe\tO\nactivity\tO\nof\tO\nthe\tO\nsinoatrial\tO\nand\tO\natrioventricular\tO\nnodal\tO\npacemakers\tO\n.\tO\n\nThe\tO\npatient\tO\nhad\tO\nno\tO\napparent\tO\nassociated\tO\nconditions\tO\nwhich\tO\nmight\tO\nhave\tO\npredisposed\tO\nhim\tO\nto\tO\nthe\tO\ndevelopment\tO\nof\tO\nbradyarrhythmias\tB-Disease\n;\tO\nand\tO\n,\tO\nthus\tO\n,\tO\nthis\tO\nprobably\tO\nrepresented\tO\na\tO\ntrue\tO\nidiosyncrasy\tO\nto\tO\nlidocaine\tB-Chemical\n.\tO\n\nFlurbiprofen\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\njuvenile\tB-Disease\nrheumatoid\tI-Disease\narthritis\tI-Disease\n.\tO\n\nThirty\tO\n-\tO\nfour\tO\npatients\tO\nwith\tO\njuvenile\tB-Disease\nrheumatoid\tI-Disease\narthritis\tI-Disease\n,\tO\nwho\tO\nwere\tO\ntreated\tO\nwith\tO\nflurbiprofen\tB-Chemical\nat\tO\na\tO\nmaximum\tO\ndose\tO\nof\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n,\tO\nhad\tO\nstatistically\tO\nsignificant\tO\ndecreases\tO\nfrom\tO\nbaseline\tO\nin\tO\n6\tO\narthritis\tB-Disease\nindices\tO\nafter\tO\n12\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nImprovements\tO\nwere\tO\nseen\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\ntender\tB-Disease\njoints\tI-Disease\n,\tO\nthe\tO\nseverity\tO\nof\tO\nswelling\tB-Disease\nand\tO\ntenderness\tB-Disease\n,\tO\nthe\tO\ntime\tO\nof\tO\nwalk\tO\n50\tO\nfeet\tO\n,\tO\nthe\tO\nduration\tO\nof\tO\nmorning\tB-Disease\nstiffness\tI-Disease\nand\tO\nthe\tO\ncircumference\tO\nof\tO\nthe\tO\nleft\tO\nknee\tO\n.\tO\n\nThe\tO\nmost\tO\nfrequently\tO\nobserved\tO\nside\tO\neffect\tO\nwas\tO\nfecal\tB-Disease\noccult\tI-Disease\nblood\tI-Disease\n(\tO\n25\tO\n%\tO\nof\tO\npatients\tO\n)\tO\n;\tO\nhowever\tO\n,\tO\nthere\tO\nwas\tO\nno\tO\nother\tO\nevidence\tO\nof\tO\ngastrointestinal\tB-Disease\n(\tI-Disease\nGI\tI-Disease\n)\tI-Disease\nbleeding\tI-Disease\nin\tO\nthese\tO\npatients\tO\n.\tO\n\nOne\tO\npatient\tO\nwas\tO\nprematurely\tO\ndiscontinued\tO\nfrom\tO\nthe\tO\nstudy\tO\nfor\tO\nsevere\tO\nheadache\tB-Disease\nand\tO\nabdominal\tB-Disease\npain\tI-Disease\n.\tO\n\nMost\tO\nside\tO\neffects\tO\nwere\tO\nmild\tO\nand\tO\nrelated\tO\nto\tO\nthe\tO\nGI\tO\ntract\tO\n.\tO\n\nHyperkalemia\tB-Disease\nassociated\tO\nwith\tO\nsulindac\tB-Chemical\ntherapy\tO\n.\tO\n\nHyperkalemia\tB-Disease\nhas\tO\nrecently\tO\nbeen\tO\nrecognized\tO\nas\tO\na\tO\ncomplication\tO\nof\tO\nnonsteroidal\tO\nantiinflammatory\tO\nagents\tO\n(\tO\nNSAID\tO\n)\tO\nsuch\tO\nas\tO\nindomethacin\tB-Chemical\n.\tO\n\nSeveral\tO\nrecent\tO\nstudies\tO\nhave\tO\nstressed\tO\nthe\tO\nrenal\tO\nsparing\tO\nfeatures\tO\nof\tO\nsulindac\tB-Chemical\n,\tO\nowing\tO\nto\tO\nits\tO\nlack\tO\nof\tO\ninterference\tO\nwith\tO\nrenal\tO\nprostacyclin\tB-Chemical\nsynthesis\tO\n.\tO\n\nWe\tO\ndescribe\tO\n4\tO\npatients\tO\nin\tO\nwhom\tO\nhyperkalemia\tB-Disease\nranging\tO\nfrom\tO\n6\tO\n.\tO\n1\tO\nto\tO\n6\tO\n.\tO\n9\tO\nmEq\tO\n/\tO\nl\tO\ndeveloped\tO\nwithin\tO\n3\tO\nto\tO\n8\tO\ndays\tO\nof\tO\nsulindac\tB-Chemical\nadministration\tO\n.\tO\n\nIn\tO\nall\tO\nof\tO\nthem\tO\nnormal\tO\nserum\tO\npotassium\tB-Chemical\nlevels\tO\nreached\tO\nwithin\tO\n2\tO\nto\tO\n4\tO\ndays\tO\nof\tO\nstopping\tO\nsulindac\tB-Chemical\n.\tO\n\nAs\tO\nno\tO\nother\tO\nmedications\tO\nknown\tO\nto\tO\neffect\tO\nserum\tO\npotassium\tB-Chemical\nhad\tO\nbeen\tO\ngiven\tO\nconcomitantly\tO\n,\tO\nthis\tO\ncourse\tO\nof\tO\nevents\tO\nis\tO\nsuggestive\tO\nof\tO\na\tO\ncause\tO\n-\tO\nand\tO\n-\tO\neffect\tO\nrelationship\tO\nbetween\tO\nsulindac\tB-Chemical\nand\tO\nhyperkalemia\tB-Disease\n.\tO\n\nThese\tO\nobservations\tO\nindicate\tO\nthat\tO\ninitial\tO\nhopes\tO\nthat\tO\nsulindac\tB-Chemical\nmay\tO\nnot\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nadverse\tO\nrenal\tO\neffects\tO\nof\tO\nother\tO\nNSAID\tO\nare\tO\nprobably\tO\nnot\tO\njustified\tO\n.\tO\n\nDrug\tO\n-\tO\ninduced\tO\narterial\tO\nspasm\tB-Disease\nrelieved\tO\nby\tO\nlidocaine\tB-Chemical\n.\tO\n\nCase\tO\nreport\tO\n.\tO\n\nFollowing\tO\nmajor\tO\nintracranial\tO\nsurgery\tO\nin\tO\na\tO\n35\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\n,\tO\nsodium\tB-Chemical\npentothal\tI-Chemical\nwas\tO\nintravenously\tO\ninfused\tO\nto\tO\nminimize\tO\ncerebral\tB-Disease\nischaemia\tI-Disease\n.\tO\n\nIntense\tO\nvasospasm\tB-Disease\nwith\tO\nthreatened\tO\ngangrene\tB-Disease\narose\tO\nin\tO\nthe\tO\narm\tO\nused\tO\nfor\tO\nthe\tO\ninfusion\tO\n.\tO\n\nSince\tO\nthe\tO\ncranial\tO\ncondition\tO\nprecluded\tO\nuse\tO\nof\tO\nmore\tO\nusual\tO\nmethods\tO\n,\tO\nlidocaine\tB-Chemical\nwas\tO\ngiven\tO\nintra\tO\n-\tO\narterially\tO\n,\tO\nwith\tO\ncareful\tO\ncardiovascular\tO\nmonitoring\tO\n,\tO\nto\tO\ncounteract\tO\nthe\tO\nvasospasm\tB-Disease\n.\tO\n\nThe\tO\ntreatment\tO\nwas\tO\nrapidly\tO\nsuccessful\tO\n.\tO\n\nRegional\tO\nlocalization\tO\nof\tO\nthe\tO\nantagonism\tO\nof\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nby\tO\nintracerebral\tO\ncalcitonin\tB-Chemical\ninjections\tO\n.\tO\n\nCalcitonin\tB-Chemical\nreceptors\tO\nare\tO\nfound\tO\nin\tO\nthe\tO\nbrain\tO\n,\tO\nand\tO\nintracerebral\tO\ninfusions\tO\nof\tO\ncalcitonin\tB-Chemical\ncan\tO\nproduce\tO\nbehavioral\tO\neffects\tO\n.\tO\n\nAmong\tO\nthese\tO\nbehavioral\tO\neffects\tO\nare\tO\ndecreases\tO\nin\tO\nfood\tO\nintake\tO\nand\tO\ndecreases\tO\nin\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nactivity\tO\n.\tO\n\nIn\tO\nprevious\tO\nexperiments\tO\nwe\tO\nfound\tO\nthat\tO\ndecreases\tO\nin\tO\nfood\tO\nintake\tO\nwere\tO\ninduced\tO\nby\tO\nlocal\tO\nadministration\tO\nof\tO\ncalcitonin\tB-Chemical\ninto\tO\nseveral\tO\nhypothalamic\tO\nsites\tO\nand\tO\ninto\tO\nthe\tO\nnucleus\tO\naccumbens\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nexperiment\tO\ncalcitonin\tB-Chemical\ndecreased\tO\nlocomotor\tO\nactivity\tO\nwhen\tO\nlocally\tO\ninjected\tO\ninto\tO\nthe\tO\nsame\tO\nsites\tO\nwhere\tO\nit\tO\ndecreases\tO\nfood\tO\nintake\tO\n.\tO\n\nThe\tO\nareas\tO\nwhere\tO\ncalcitonin\tB-Chemical\nis\tO\nmost\tO\neffective\tO\nin\tO\ndecreasing\tO\nlocomotor\tO\nactivity\tO\nare\tO\nlocated\tO\nin\tO\nthe\tO\nhypothalamus\tO\nand\tO\nnucleus\tO\naccumbens\tO\n,\tO\nsuggesting\tO\nthat\tO\nthese\tO\nareas\tO\nare\tO\nthe\tO\nmajor\tO\nsites\tO\nof\tO\naction\tO\nof\tO\ncalcitonin\tB-Chemical\nin\tO\ninhibiting\tO\namphetamine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tO\nactivity\tO\n.\tO\n\nThe\tO\nhematologic\tO\neffects\tO\nof\tO\ncefonicid\tB-Chemical\nand\tO\ncefazedone\tB-Chemical\nin\tO\nthe\tO\ndog\tO\n:\tO\na\tO\npotential\tO\nmodel\tO\nof\tO\ncephalosporin\tB-Chemical\nhematotoxicity\tB-Disease\nin\tO\nman\tO\n.\tO\n\nCephalosporin\tB-Chemical\nantibiotics\tO\ncause\tO\na\tO\nvariety\tO\nof\tO\nhematologic\tB-Disease\ndisturbances\tI-Disease\nin\tO\nman\tO\n,\tO\nthe\tO\npathogeneses\tO\nand\tO\nhematopathology\tO\nof\tO\nwhich\tO\nremain\tO\npoorly\tO\ncharacterized\tO\n.\tO\n\nThere\tO\nis\tO\na\tO\nneed\tO\nfor\tO\na\tO\nwell\tO\n-\tO\ndefined\tO\nanimal\tO\nmodel\tO\nin\tO\nwhich\tO\nthese\tO\nblood\tB-Disease\ndyscrasias\tI-Disease\ncan\tO\nbe\tO\nstudied\tO\n.\tO\n\nIn\tO\nfour\tO\nsubacute\tO\ntoxicity\tB-Disease\nstudies\tO\n,\tO\nthe\tO\nintravenous\tO\nadministration\tO\nof\tO\ncefonicid\tB-Chemical\nor\tO\ncefazedone\tB-Chemical\nto\tO\nbeagle\tO\ndogs\tO\ncaused\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nincidence\tO\nof\tO\nanemia\tB-Disease\n,\tO\nneutropenia\tB-Disease\n,\tO\nand\tO\nthrombocytopenia\tB-Disease\nafter\tO\n1\tO\n-\tO\n3\tO\nmonths\tO\nof\tO\ntreatment\tO\n.\tO\n\nA\tO\nnonregenerative\tO\nanemia\tB-Disease\nwas\tO\nthe\tO\nmost\tO\ncompromising\tO\nof\tO\nthe\tO\ncytopenias\tB-Disease\nand\tO\noccurred\tO\nin\tO\napproximately\tO\n50\tO\n%\tO\nof\tO\ndogs\tO\nreceiving\tO\n400\tO\n-\tO\n500\tO\nmg\tO\n/\tO\nkg\tO\ncefonicid\tB-Chemical\nor\tO\n540\tO\n-\tO\n840\tO\nmg\tO\n/\tO\nkg\tO\ncefazedone\tB-Chemical\n.\tO\n\nAll\tO\nthree\tO\ncytopenias\tB-Disease\nwere\tO\ncompletely\tO\nreversible\tO\nfollowing\tO\ncessation\tO\nof\tO\ntreatment\tO\n;\tO\nthe\tO\ntime\tO\nrequired\tO\nfor\tO\nrecovery\tO\nof\tO\nthe\tO\nerythron\tO\n(\tO\napproximately\tO\n1\tO\nmonth\tO\n)\tO\nwas\tO\nconsiderably\tO\nlonger\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\ngranulocytes\tO\nand\tO\nplatelets\tO\n(\tO\nhours\tO\nto\tO\na\tO\nfew\tO\ndays\tO\n)\tO\n.\tO\n\nUpon\tO\nrechallenge\tO\nwith\tO\neither\tO\ncephalosporin\tB-Chemical\n,\tO\nthe\tO\nhematologic\tB-Disease\nsyndrome\tI-Disease\nwas\tO\nreproduced\tO\nin\tO\nmost\tO\ndogs\tO\ntested\tO\n;\tO\ncefonicid\tB-Chemical\n(\tO\nbut\tO\nnot\tO\ncefazedone\tB-Chemical\n)\tO\n-\tO\ntreated\tO\ndogs\tO\nshowed\tO\na\tO\nsubstantially\tO\nreduced\tO\ninduction\tO\nperiod\tO\n(\tO\n15\tO\n+\tO\n/\tO\n-\tO\n5\tO\ndays\tO\n)\tO\ncompared\tO\nto\tO\nthat\tO\nof\tO\nthe\tO\nfirst\tO\nexposure\tO\nto\tO\nthe\tO\ndrug\tO\n(\tO\n61\tO\n+\tO\n/\tO\n-\tO\n24\tO\ndays\tO\n)\tO\n.\tO\n\nThis\tO\nobservation\tO\n,\tO\nalong\tO\nwith\tO\nthe\tO\nrapid\tO\nrate\tO\nof\tO\ndecline\tO\nin\tO\nred\tO\ncell\tO\nmass\tO\nparameters\tO\nof\tO\naffected\tO\ndogs\tO\n,\tO\nsuggests\tO\nthat\tO\na\tO\nhemolytic\tB-Disease\ncomponent\tO\ncomplicated\tO\nthe\tO\nred\tO\ncell\tO\nproduction\tO\nproblem\tO\nand\tO\nthat\tO\nmultiple\tO\ntoxicologic\tO\nmechanisms\tO\ncontributed\tO\nto\tO\nthe\tO\ncytopenia\tB-Disease\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nthe\tO\nadministration\tO\nof\tO\nhigh\tO\ndoses\tO\nof\tO\ncefonicid\tB-Chemical\nor\tO\ncefazedone\tB-Chemical\nto\tO\ndogs\tO\ncan\tO\ninduce\tO\nhematotoxicity\tB-Disease\nsimilar\tO\nto\tO\nthe\tO\ncephalosporin\tB-Chemical\n-\tO\ninduced\tO\nblood\tB-Disease\ndyscrasias\tI-Disease\ndescribed\tO\nin\tO\nman\tO\nand\tO\nthus\tO\nprovides\tO\na\tO\nuseful\tO\nmodel\tO\nfor\tO\nstudying\tO\nthe\tO\nmechanisms\tO\nof\tO\nthese\tO\ndisorders\tO\n.\tO\n\nCerebral\tO\nblood\tO\nflow\tO\nand\tO\nmetabolism\tO\nduring\tO\nisoflurane\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nin\tO\npatients\tO\nsubjected\tO\nto\tO\nsurgery\tO\nfor\tO\ncerebral\tB-Disease\naneurysms\tI-Disease\n.\tO\n\nCerebral\tO\nblood\tO\nflow\tO\nand\tO\ncerebral\tO\nmetabolic\tO\nrate\tO\nfor\tO\noxygen\tB-Chemical\nwere\tO\nmeasured\tO\nduring\tO\nisoflurane\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nin\tO\n10\tO\npatients\tO\nsubjected\tO\nto\tO\ncraniotomy\tO\nfor\tO\nclipping\tO\nof\tO\na\tO\ncerebral\tB-Disease\naneurysm\tI-Disease\n.\tO\n\nFlow\tO\nand\tO\nmetabolism\tO\nwere\tO\nmeasured\tO\n5\tO\n-\tO\n13\tO\ndays\tO\nafter\tO\nthe\tO\nsubarachnoid\tB-Disease\nhaemorrhage\tI-Disease\nby\tO\na\tO\nmodification\tO\nof\tO\nthe\tO\nclassical\tO\nKety\tO\n-\tO\nSchmidt\tO\ntechnique\tO\nusing\tO\nxenon\tB-Chemical\n-\tO\n133\tO\ni\tO\n.\tO\nv\tO\n.\tO\nAnaesthesia\tO\nwas\tO\nmaintained\tO\nwith\tO\nan\tO\ninspired\tO\nisoflurane\tB-Chemical\nconcentration\tO\nof\tO\n0\tO\n.\tO\n75\tO\n%\tO\n(\tO\nplus\tO\n67\tO\n%\tO\nnitrous\tB-Chemical\noxide\tI-Chemical\nin\tO\noxygen\tB-Chemical\n)\tO\n,\tO\nduring\tO\nwhich\tO\nCBF\tO\nand\tO\nCMRO2\tO\nwere\tO\n34\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\nml\tO\n/\tO\n100\tO\ng\tO\nmin\tO\n-\tO\n1\tO\nand\tO\n2\tO\n.\tO\n32\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n16\tO\nml\tO\n/\tO\n100\tO\ng\tO\nmin\tO\n-\tO\n1\tO\nat\tO\nPaCO2\tO\n4\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\nkPa\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSEM\tO\n)\tO\n.\tO\n\nControlled\tO\nhypotension\tB-Disease\nto\tO\nan\tO\naverage\tO\nMAP\tO\nof\tO\n50\tO\n-\tO\n55\tO\nmm\tO\nHg\tB-Chemical\nwas\tO\ninduced\tO\nby\tO\nincreasing\tO\nthe\tO\ndose\tO\nof\tO\nisoflurane\tB-Chemical\n,\tO\nand\tO\nmaintained\tO\nat\tO\nan\tO\ninspired\tO\nconcentration\tO\nof\tO\n2\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n2\tO\n%\tO\n.\tO\n\nThis\tO\nresulted\tO\nin\tO\na\tO\nsignificant\tO\ndecrease\tO\nin\tO\nCMRO2\tO\n(\tO\nto\tO\n1\tO\n.\tO\n73\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n16\tO\nml\tO\n/\tO\n100\tO\ng\tO\nmin\tO\n-\tO\n1\tO\n)\tO\n,\tO\nwhile\tO\nCBF\tO\nwas\tO\nunchanged\tO\n.\tO\n\nAfter\tO\nthe\tO\nclipping\tO\nof\tO\nthe\tO\naneurysm\tB-Disease\nthe\tO\nisoflurane\tB-Chemical\nconcentration\tO\nwas\tO\nreduced\tO\nto\tO\n0\tO\n.\tO\n75\tO\n%\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\nincrease\tO\nin\tO\nCBF\tO\n,\tO\nalthough\tO\nCMRO2\tO\nwas\tO\nunchanged\tO\n,\tO\ncompared\tO\nwith\tO\npre\tO\n-\tO\nhypotensive\tB-Disease\nvalues\tO\n.\tO\n\nThese\tO\nchanges\tO\nmight\tO\noffer\tO\nprotection\tO\nto\tO\nbrain\tO\ntissue\tO\nduring\tO\nperiods\tO\nof\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nTriazolam\tB-Chemical\n-\tO\ninduced\tO\nbrief\tO\nepisodes\tO\nof\tO\nsecondary\tO\nmania\tB-Disease\nin\tO\na\tO\ndepressed\tB-Disease\npatient\tO\n.\tO\n\nLarge\tO\ndoses\tO\nof\tO\ntriazolam\tB-Chemical\nrepeatedly\tO\ninduced\tO\nbrief\tO\nepisodes\tO\nof\tO\nmania\tB-Disease\nin\tO\na\tO\ndepressed\tB-Disease\nelderly\tO\nwoman\tO\n.\tO\n\nFeatures\tO\nof\tO\norganic\tB-Disease\nmental\tI-Disease\ndisorder\tI-Disease\n(\tO\ndelirium\tB-Disease\n)\tO\nwere\tO\nnot\tO\npresent\tO\n.\tO\n\nManic\tB-Disease\nexcitement\tO\nwas\tO\ncoincident\tO\nwith\tO\nthe\tO\nduration\tO\nof\tO\naction\tO\nof\tO\ntriazolam\tB-Chemical\n.\tO\n\nThe\tO\npossible\tO\ncontribution\tO\nof\tO\nthe\tO\ntriazolo\tB-Chemical\ngroup\tO\nto\tO\nchanges\tO\nin\tO\naffective\tO\nstatus\tO\nis\tO\ndiscussed\tO\n.\tO\n\nThe\tO\ncorrelation\tO\nbetween\tO\nneurotoxic\tB-Disease\nesterase\tO\ninhibition\tO\nand\tO\nmipafox\tB-Chemical\n-\tO\ninduced\tO\nneuropathic\tB-Disease\ndamage\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\ncorrelation\tO\nbetween\tO\nneuropathic\tB-Disease\ndamage\tI-Disease\nand\tO\ninhibition\tO\nof\tO\nneurotoxic\tB-Disease\nesterase\tO\nor\tO\nneuropathy\tB-Disease\ntarget\tO\nenzyme\tO\n(\tO\nNTE\tO\n)\tO\nwas\tO\nexamined\tO\nin\tO\nrats\tO\nacutely\tO\nexposed\tO\nto\tO\nMipafox\tB-Chemical\n(\tO\nN\tB-Chemical\n,\tI-Chemical\nN\tI-Chemical\n'\tI-Chemical\n-\tI-Chemical\ndiisopropylphosphorodiamidofluoridate\tI-Chemical\n)\tO\n,\tO\na\tO\nneurotoxic\tB-Disease\norganophosphate\tB-Chemical\n.\tO\n\nBrain\tO\nand\tO\nspinal\tO\ncord\tO\nNTE\tO\nactivities\tO\nwere\tO\nmeasured\tO\nin\tO\nLong\tO\n-\tO\nEvans\tO\nmale\tO\nrats\tO\n1\tO\nhr\tO\npost\tO\n-\tO\nexposure\tO\nto\tO\nvarious\tO\ndosages\tO\nof\tO\nMipafox\tB-Chemical\n(\tO\nip\tO\n,\tO\n1\tO\n-\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nThese\tO\ndata\tO\nwere\tO\ncorrelated\tO\nwith\tO\nhistologically\tO\nscored\tO\ncervical\tO\ncord\tB-Disease\ndamage\tI-Disease\nin\tO\na\tO\nseparate\tO\ngroup\tO\nof\tO\nsimilarly\tO\ndosed\tO\nrats\tO\nsampled\tO\n14\tO\n-\tO\n21\tO\ndays\tO\npost\tO\n-\tO\nexposure\tO\n.\tO\n\nThose\tO\ndosages\tO\n(\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nthat\tO\ninhibited\tO\nmean\tO\nNTE\tO\nactivity\tO\nin\tO\nthe\tO\nspinal\tO\ncord\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n73\tO\n%\tO\nand\tO\nbrain\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n67\tO\n%\tO\nof\tO\ncontrol\tO\nvalues\tO\nproduced\tO\nsevere\tO\n(\tO\ngreater\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n3\tO\n)\tO\ncervical\tO\ncord\tO\npathology\tO\nin\tO\n85\tO\n%\tO\nof\tO\nthe\tO\nrats\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\ndosages\tO\nof\tO\nMipafox\tB-Chemical\n(\tO\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwhich\tO\ninhibited\tO\nmean\tO\nNTE\tO\nactivity\tO\nin\tO\nspinal\tO\ncord\tO\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n61\tO\n%\tO\nand\tO\nbrain\tO\nless\tO\nthan\tO\nor\tO\nequal\tO\nto\tO\n60\tO\n%\tO\nproduced\tO\nthis\tO\ndegree\tO\nof\tO\ncord\tB-Disease\ndamage\tI-Disease\nin\tO\nonly\tO\n9\tO\n%\tO\nof\tO\nthe\tO\nanimals\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\na\tO\ncritical\tO\npercentage\tO\nof\tO\nNTE\tO\ninhibition\tO\nin\tO\nbrain\tO\nand\tO\nspinal\tO\ncord\tO\nsampled\tO\nshortly\tO\nafter\tO\nMipafox\tB-Chemical\nexposure\tO\ncan\tO\npredict\tO\nneuropathic\tB-Disease\ndamage\tI-Disease\nin\tO\nrats\tO\nseveral\tO\nweeks\tO\nlater\tO\n.\tO\n\nAllergic\tB-Disease\nreaction\tI-Disease\nto\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\ninfusion\tO\n.\tO\n\nAn\tO\nallergic\tB-Disease\nreaction\tI-Disease\nconsisting\tO\nof\tO\nangioneurotic\tB-Disease\nedema\tI-Disease\nsecondary\tO\nto\tO\ncontinuous\tO\ninfusion\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\noccurred\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nrecurrent\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\noral\tI-Disease\ncavity\tI-Disease\n,\tO\ncirrhosis\tB-Disease\n,\tO\nand\tO\ncisplatin\tB-Chemical\n-\tO\ninduced\tO\nimpaired\tB-Disease\nrenal\tI-Disease\nfunction\tI-Disease\n.\tO\n\nThis\tO\nreaction\tO\noccurred\tO\nduring\tO\nthe\tO\nsixth\tO\nand\tO\nseventh\tO\ncourses\tO\nof\tO\ninfusional\tO\nchemotherapy\tO\n.\tO\n\nOral\tO\ndiphenhydramine\tB-Chemical\nand\tO\nprednisone\tB-Chemical\nwere\tO\nineffective\tO\nin\tO\npreventing\tO\nthe\tO\nrecurrence\tO\nof\tO\nthe\tO\nallergic\tB-Disease\nreaction\tI-Disease\n.\tO\n\nDiscontinuance\tO\nof\tO\neffective\tO\nchemotherapy\tO\nin\tO\nthis\tO\npatient\tO\nduring\tO\npartial\tO\nremission\tO\nresulted\tO\nin\tO\nfatal\tO\ndisease\tO\nprogression\tO\n.\tO\n\nMyasthenia\tB-Disease\ngravis\tI-Disease\ncaused\tO\nby\tO\npenicillamine\tB-Chemical\nand\tO\nchloroquine\tB-Chemical\ntherapy\tO\nfor\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nWe\tO\nhave\tO\ndescribed\tO\na\tO\nunique\tO\npatient\tO\nwho\tO\nhad\tO\nreversible\tO\nand\tO\ndose\tO\n-\tO\nrelated\tO\nmyasthenia\tB-Disease\ngravis\tI-Disease\nafter\tO\npenicillamine\tB-Chemical\nand\tO\nchloroquine\tB-Chemical\ntherapy\tO\nfor\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nAlthough\tO\nacetylcholine\tB-Chemical\nreceptor\tO\nantibodies\tO\nwere\tO\nnot\tO\ndetectable\tO\n,\tO\nthe\tO\ntime\tO\ncourse\tO\nwas\tO\nconsistent\tO\nwith\tO\nan\tO\nautoimmune\tO\nprocess\tO\n.\tO\n\nOn\tO\nthe\tO\nmechanisms\tO\nof\tO\nthe\tO\ndevelopment\tO\nof\tO\ntolerance\tO\nto\tO\nthe\tO\nmuscular\tB-Disease\nrigidity\tI-Disease\nproduced\tO\nby\tO\nmorphine\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\ntolerance\tO\nto\tO\nthe\tO\nmuscular\tB-Disease\nrigidity\tI-Disease\nproduced\tO\nby\tO\nmorphine\tB-Chemical\nwas\tO\nstudied\tO\nin\tO\nrats\tO\n.\tO\n\nSaline\tO\n-\tO\npretreated\tO\ncontrols\tO\ngiven\tO\na\tO\ntest\tO\ndose\tO\nof\tO\nmorphine\tB-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nshowed\tO\na\tO\npronounced\tO\nrigidity\tB-Disease\nrecorded\tO\nas\tO\ntonic\tO\nactivity\tO\nin\tO\nthe\tO\nelectromyogram\tO\n.\tO\n\nRats\tO\ntreated\tO\nfor\tO\n11\tO\ndays\tO\nwith\tO\nmorphine\tB-Chemical\nand\tO\nwithdrawn\tO\nfor\tO\n36\tO\n-\tO\n40\tO\nh\tO\nshowed\tO\ndifferences\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\ntolerance\tO\n:\tO\nabout\tO\nhalf\tO\nof\tO\nthe\tO\nanimals\tO\nshowed\tO\na\tO\nrigidity\tB-Disease\nafter\tO\nthe\tO\ntest\tO\ndose\tO\nof\tO\nmorphine\tB-Chemical\nthat\tO\nwas\tO\nnot\tO\nsignificantly\tO\nless\tO\nthan\tO\nin\tO\nthe\tO\ncontrols\tO\nand\tO\nwere\tO\nakinetic\tB-Disease\n(\tO\nA\tO\ngroup\tO\n)\tO\n.\tO\n\nThe\tO\nother\tO\nrats\tO\nshowed\tO\na\tO\nstrong\tO\ndecrease\tO\nin\tO\nthe\tO\nrigidity\tB-Disease\nand\tO\nthe\tO\noccurrence\tO\nof\tO\nstereotyped\tO\n(\tO\nS\tO\n)\tO\nlicking\tO\nand\tO\n/\tO\nor\tO\ngnawing\tO\nin\tO\npresence\tO\nof\tO\nakinetic\tB-Disease\nor\tO\nhyperkinetic\tB-Disease\n(\tO\nK\tO\n)\tO\nbehaviour\tO\n(\tO\nAS\tO\n/\tO\nKS\tO\ngroup\tO\n)\tO\n,\tO\nsuggesting\tO\nsigns\tO\nof\tO\ndopaminergic\tO\nactivation\tO\n.\tO\n\nThe\tO\nrigidity\tB-Disease\nwas\tO\nconsiderably\tO\ndecreased\tO\nin\tO\nboth\tO\ngroups\tO\nafter\tO\n20\tO\ndays\tO\n'\tO\ntreatment\tO\n.\tO\n\nIn\tO\na\tO\nfurther\tO\nseries\tO\nof\tO\nexperiments\tO\n,\tO\nhaloperidol\tB-Chemical\n(\tO\n0\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nwas\tO\nused\tO\nin\tO\norder\tO\nto\tO\nblock\tO\nthe\tO\ndopaminergic\tO\nactivation\tO\nand\tO\nto\tO\nestimate\tO\nthe\tO\nreal\tO\ndegree\tO\nof\tO\nthe\tO\ntolerance\tO\nto\tO\nthe\tO\nrigidity\tB-Disease\nwithout\tO\nany\tO\ndopaminergic\tO\ninterference\tO\n.\tO\n\nHaloperidol\tB-Chemical\nenhanced\tO\nthe\tO\nrigidity\tB-Disease\nin\tO\nthe\tO\nA\tO\ngroup\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nlevel\tO\nin\tO\nthe\tO\nAS\tO\n/\tO\nKS\tO\ngroup\tO\nremained\tO\nconsiderably\tO\nlower\tO\nthan\tO\nin\tO\nthe\tO\nA\tO\ngroup\tO\n.\tO\n\nThe\tO\nresults\tO\nsuggest\tO\nthat\tO\nrigidity\tB-Disease\n,\tO\nwhich\tO\nis\tO\nassumed\tO\nto\tO\nbe\tO\ndue\tO\nto\tO\nan\tO\naction\tO\nof\tO\nmorphine\tB-Chemical\nin\tO\nthe\tO\nstriatum\tO\n,\tO\ncan\tO\nbe\tO\nantagonized\tO\nby\tO\nanother\tO\nprocess\tO\nleading\tO\nto\tO\ndopaminergic\tO\nactivation\tO\nin\tO\nthe\tO\nstriatum\tO\n.\tO\n\nNevertheless\tO\n,\tO\nthere\tO\noccurs\tO\nsome\tO\nreal\tO\ntolerance\tO\nto\tO\nthis\tO\neffect\tO\n.\tO\n\nThe\tO\nrapid\tO\nalternations\tO\nof\tO\nrigidity\tB-Disease\nand\tO\nthe\tO\nsigns\tO\nof\tO\ndopaminergic\tO\nactivation\tO\nobserved\tO\nin\tO\nthe\tO\nanimals\tO\nof\tO\nthe\tO\nAS\tO\n/\tO\nKS\tO\ngroup\tO\nmight\tO\nbe\tO\ndue\tO\nto\tO\nrapid\tO\nshifts\tO\nin\tO\nthe\tO\npredominance\tO\nof\tO\nvarious\tO\nDA\tO\n-\tO\ninnervated\tO\nstructures\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\nmassive\tO\nrhabdomyolysis\tB-Disease\nfollowing\tO\nmolindone\tB-Chemical\nadministration\tO\n.\tO\n\nRhabdomyolysis\tB-Disease\nis\tO\na\tO\npotentially\tO\nlethal\tO\nsyndrome\tO\nthat\tO\npsychiatric\tB-Disease\npatients\tO\nseem\tO\npredisposed\tO\nto\tO\ndevelop\tO\n.\tO\n\nThe\tO\nclinical\tO\nsigns\tO\nand\tO\nsymptoms\tO\n,\tO\ntypical\tO\nlaboratory\tO\nfeatures\tO\n,\tO\nand\tO\ncomplications\tO\nof\tO\nrhabdomyolysis\tB-Disease\nare\tO\npresented\tO\n.\tO\n\nThe\tO\ncase\tO\nof\tO\na\tO\nschizophrenic\tB-Disease\npatient\tO\nis\tO\nreported\tO\nto\tO\nillustrate\tO\nmassive\tO\nrhabdomyolysis\tB-Disease\nand\tO\nsubsequent\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nfollowing\tO\nmolindone\tB-Chemical\nadministration\tO\n.\tO\n\nPhysicians\tO\nwho\tO\nprescribe\tO\nmolindone\tB-Chemical\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\nreaction\tO\n.\tO\n\nCompression\tB-Disease\nneuropathy\tI-Disease\nof\tI-Disease\nthe\tI-Disease\nradial\tI-Disease\nnerve\tI-Disease\ndue\tO\nto\tO\npentazocine\tB-Chemical\n-\tO\ninduced\tO\nfibrous\tB-Disease\nmyopathy\tI-Disease\n.\tO\n\nFibrous\tB-Disease\nmyopathy\tI-Disease\nis\tO\na\tO\ncommon\tO\n,\tO\nwell\tO\n-\tO\nknown\tO\nside\tO\neffect\tO\nof\tO\nrepeated\tO\npentazocine\tB-Chemical\ninjection\tO\n.\tO\n\nHowever\tO\n,\tO\ncompression\tB-Disease\nneuropathy\tI-Disease\ndue\tO\nto\tO\nfibrotic\tO\nmuscle\tO\naffected\tO\nby\tO\npentazocine\tB-Chemical\n-\tO\ninduced\tO\nmyopathy\tB-Disease\nhas\tO\nnot\tO\npreviously\tO\nbeen\tO\nreported\tO\n.\tO\n\nIn\tO\na\tO\n37\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\ndocumented\tO\npentazocine\tB-Chemical\n-\tO\ninduced\tO\nfibrous\tB-Disease\nmyopathy\tI-Disease\nof\tO\ntriceps\tO\nand\tO\ndeltoid\tO\nmuscles\tO\nbilaterally\tO\nand\tO\na\tO\nthree\tO\n-\tO\nweek\tO\nhistory\tO\nof\tO\nright\tO\nwrist\tO\ndrop\tO\n,\tO\nelectrodiagnostic\tO\nexamination\tO\nshowed\tO\na\tO\nsevere\tO\nbut\tO\npartial\tO\nlesion\tO\nof\tO\nthe\tO\nright\tO\nradial\tO\nnerve\tO\ndistal\tO\nto\tO\nthe\tO\nbranches\tO\nto\tO\nthe\tO\ntriceps\tO\n,\tO\nin\tO\naddition\tO\nto\tO\nthe\tO\nfibrous\tB-Disease\nmyopathy\tI-Disease\n.\tO\n\nSurgery\tO\nrevealed\tO\nthe\tO\nright\tO\nradial\tO\nnerve\tO\nto\tO\nbe\tO\nseverely\tO\ncompressed\tO\nby\tO\nthe\tO\ndensely\tO\nfibrotic\tO\nlateral\tO\nhead\tO\nof\tO\nthe\tO\ntriceps\tO\n.\tO\n\nDecompression\tO\nand\tO\nneurolysis\tO\nwere\tO\nperformed\tO\nwith\tO\ngood\tO\nsubsequent\tO\nrecovery\tO\nof\tO\nfunction\tO\n.\tO\n\nRecurrent\tO\nreversible\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nfrom\tO\namphotericin\tB-Chemical\n.\tO\n\nA\tO\npatient\tO\nwith\tO\ncryptogenic\tO\ncirrhosis\tB-Disease\nand\tO\ndisseminated\tO\nsporotrichosis\tB-Disease\ndeveloped\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nimmediately\tO\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\namphotericin\tB-Chemical\nB\tI-Chemical\non\tO\nfour\tO\nseparate\tO\noccasions\tO\n.\tO\n\nThe\tO\nabruptness\tO\nof\tO\nthe\tO\nrenal\tB-Disease\nfailure\tI-Disease\nand\tO\nits\tO\nreversibility\tO\nwithin\tO\ndays\tO\nsuggests\tO\nthat\tO\nthere\tO\nwas\tO\na\tO\nfunctional\tO\ncomponent\tO\nto\tO\nthe\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nWe\tO\npropose\tO\nthat\tO\namphotericin\tB-Chemical\n,\tO\nin\tO\nthe\tO\nsetting\tO\nof\tO\nreduced\tO\neffective\tO\narterial\tO\nvolume\tO\n,\tO\nmay\tO\nactivate\tO\ntubuloglomerular\tO\nfeedback\tO\n,\tO\nthereby\tO\ncontributing\tO\nto\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nCerebral\tB-Disease\ninfarction\tI-Disease\nwith\tO\na\tO\nsingle\tO\noral\tO\ndose\tO\nof\tO\nphenylpropanolamine\tB-Chemical\n.\tO\n\nPhenylpropanolamine\tB-Chemical\n(\tO\nPPA\tB-Chemical\n)\tO\n,\tO\na\tO\nsynthetic\tO\nsympathomimetic\tO\nthat\tO\nis\tO\nstructurally\tO\nsimilar\tO\nto\tO\namphetamine\tB-Chemical\n,\tO\nis\tO\navailable\tO\nover\tO\nthe\tO\ncounter\tO\nin\tO\nanorectics\tO\n,\tO\nnasal\tO\ncongestants\tO\n,\tO\nand\tO\ncold\tO\npreparations\tO\n.\tO\n\nIts\tO\nprolonged\tO\nuse\tO\nor\tO\noveruse\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nseizures\tB-Disease\n,\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n,\tO\nneuropsychiatric\tB-Disease\nsymptoms\tI-Disease\n,\tO\nand\tO\nnonhemorrhagic\tO\ncerebral\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\nyoung\tO\nwoman\tO\nwho\tO\nsuffered\tO\na\tO\ncerebral\tB-Disease\ninfarction\tI-Disease\nafter\tO\ntaking\tO\na\tO\nsingle\tO\noral\tO\ndose\tO\nof\tO\nPPA\tB-Chemical\n.\tO\n\nRemission\tO\ninduction\tO\nof\tO\nmeningeal\tB-Disease\nleukemia\tI-Disease\nwith\tO\nhigh\tO\n-\tO\ndose\tO\nintravenous\tO\nmethotrexate\tB-Chemical\n.\tO\n\nTwenty\tO\nchildren\tO\nwith\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\nwho\tO\ndeveloped\tO\nmeningeal\tB-Disease\ndisease\tI-Disease\nwere\tO\ntreated\tO\nwith\tO\na\tO\nhigh\tO\n-\tO\ndose\tO\nintravenous\tO\nmethotrexate\tB-Chemical\nregimen\tO\nthat\tO\nwas\tO\ndesigned\tO\nto\tO\nachieve\tO\nand\tO\nmaintain\tO\nCSF\tO\nmethotrexate\tB-Chemical\nconcentrations\tO\nof\tO\n10\tO\n(\tO\n-\tO\n5\tO\n)\tO\nmol\tO\n/\tO\nL\tO\nwithout\tO\nthe\tO\nneed\tO\nfor\tO\nconcomitant\tO\nintrathecal\tO\ndosing\tO\n.\tO\n\nThe\tO\nmethotrexate\tB-Chemical\nwas\tO\nadministered\tO\nas\tO\na\tO\nloading\tO\ndose\tO\nof\tO\n6\tO\n,\tO\n000\tO\nmg\tO\n/\tO\nm2\tO\nfor\tO\na\tO\nperiod\tO\nof\tO\none\tO\nhour\tO\nfollowed\tO\nby\tO\nan\tO\ninfusion\tO\nof\tO\n1\tO\n,\tO\n200\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nh\tO\nfor\tO\n23\tO\nhours\tO\n.\tO\n\nLeucovorin\tB-Chemical\nrescue\tO\nwas\tO\ninitiated\tO\n12\tO\nhours\tO\nafter\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\ninfusion\tO\nwith\tO\na\tO\nloading\tO\ndose\tO\nof\tO\n200\tO\nmg\tO\n/\tO\nm2\tO\nfollowed\tO\nby\tO\n12\tO\nmg\tO\n/\tO\nm2\tO\nevery\tO\nthree\tO\nhours\tO\nfor\tO\nsix\tO\ndoses\tO\nand\tO\nthen\tO\nevery\tO\nsix\tO\nhours\tO\nuntil\tO\nthe\tO\nplasma\tO\nmethotrexate\tB-Chemical\nlevel\tO\ndecreased\tO\nto\tO\nless\tO\nthan\tO\n1\tO\nX\tO\n10\tO\n(\tO\n-\tO\n7\tO\n)\tO\nmol\tO\n/\tO\nL\tO\n.\tO\n\nThe\tO\nmean\tO\nsteady\tO\n-\tO\nstate\tO\nplasma\tO\nand\tO\nCSF\tO\nmethotrexate\tB-Chemical\nconcentrations\tO\nachieved\tO\nwere\tO\n1\tO\n.\tO\n1\tO\nX\tO\n10\tO\n(\tO\n-\tO\n3\tO\n)\tO\nmol\tO\n/\tO\nL\tO\nand\tO\n3\tO\n.\tO\n6\tO\nX\tO\n10\tO\n(\tO\n-\tO\n5\tO\n)\tO\nmol\tO\n/\tO\nL\tO\n,\tO\nrespectively\tO\n.\tO\n\nAll\tO\n20\tO\npatients\tO\nresponded\tO\nto\tO\nthis\tO\nregimen\tO\n,\tO\n16\tO\n/\tO\n20\tO\n(\tO\n80\tO\n%\tO\n)\tO\nachieved\tO\na\tO\ncomplete\tO\nremission\tO\n,\tO\nand\tO\n20\tO\n%\tO\nobtained\tO\na\tO\npartial\tO\nremission\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\ntoxicities\tB-Disease\nencountered\tO\nwere\tO\ntransient\tO\nserum\tO\ntransaminase\tO\nand\tO\nbilirubin\tB-Chemical\nelevations\tO\n,\tO\nneutropenia\tB-Disease\n,\tO\nand\tO\nmucositis\tB-Disease\n.\tO\n\nOne\tO\npatient\tO\nhad\tO\nfocal\tO\nseizures\tB-Disease\nand\tO\ntransient\tB-Disease\nhemiparesis\tI-Disease\nbut\tO\nrecovered\tO\ncompletely\tO\n.\tO\n\nHigh\tO\n-\tO\ndose\tO\nintravenous\tO\nmethotrexate\tB-Chemical\nis\tO\nan\tO\neffective\tO\ntreatment\tO\nfor\tO\nthe\tO\ninduction\tO\nof\tO\nremission\tO\nafter\tO\nmeningeal\tO\nrelapse\tO\nin\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleukemia\tI-Disease\n.\tO\n\nInteraction\tO\nof\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\nwith\tO\nantineoplastic\tO\nagents\tO\n.\tO\n\nA\tO\nsynergistic\tO\neffect\tO\nof\tO\netoposide\tB-Chemical\nand\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\nwas\tO\nobserved\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nacute\tB-Disease\nT\tI-Disease\n-\tI-Disease\nlymphocytic\tI-Disease\nleukemia\tI-Disease\nin\tO\nrelapse\tO\n.\tO\n\nThe\tO\nconcomitant\tO\nadministration\tO\nof\tO\netoposide\tB-Chemical\nand\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\nresulted\tO\nin\tO\neradication\tO\nof\tO\nhitherto\tO\nrefractory\tO\nleukemic\tB-Disease\ninfiltration\tI-Disease\nof\tO\nbone\tO\nmarrow\tO\n.\tO\n\nSevere\tO\nside\tO\neffects\tO\nin\tO\nterms\tO\nof\tO\nmental\tO\nconfusion\tB-Disease\nand\tO\nprogressive\tO\nhyperbilirubinemia\tB-Disease\n,\tO\nhowever\tO\n,\tO\npoint\tO\nto\tO\nan\tO\nenhancement\tO\nnot\tO\nonly\tO\nof\tO\nantineoplastic\tO\neffects\tO\nbut\tO\nalso\tO\nof\tO\ntoxicity\tB-Disease\nin\tO\nnormal\tO\ntissues\tO\n.\tO\n\nThis\tO\nreport\tO\ndemonstrates\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nthat\tO\nthe\tO\npharmacodynamic\tO\nproperties\tO\nof\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\nmay\tO\nnot\tO\nbe\tO\nconfined\tO\nstrictly\tO\nto\tO\nsuppression\tO\nof\tO\nnormal\tO\nT\tO\n-\tO\ncell\tO\nfunctions\tO\n.\tO\n\nIncidence\tO\nof\tO\nneoplasms\tB-Disease\nin\tO\npatients\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\nexposed\tO\nto\tO\ndifferent\tO\ntreatment\tO\nregimens\tO\n.\tO\n\nImmunosuppressive\tO\ndrugs\tO\nhave\tO\nbeen\tO\nused\tO\nduring\tO\nthe\tO\nlast\tO\n30\tO\nyears\tO\nin\tO\ntreatment\tO\nof\tO\npatients\tO\nwith\tO\nsevere\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nThe\tO\ndrugs\tO\ncommonly\tO\nused\tO\nare\tO\ncyclophosphamide\tB-Chemical\nand\tO\nchlorambucil\tB-Chemical\n(\tO\nalkylating\tB-Chemical\nagents\tI-Chemical\n)\tO\n,\tO\nazathioprine\tB-Chemical\n(\tO\npurine\tB-Chemical\nanalogue\tO\n)\tO\n,\tO\nand\tO\nmethotrexate\tB-Chemical\n(\tO\nfolic\tB-Chemical\nacid\tI-Chemical\nanalogue\tO\n)\tO\n.\tO\n\nThere\tO\nis\tO\nevidence\tO\nthat\tO\nall\tO\nfour\tO\nimmunosuppressive\tO\ndrugs\tO\ncan\tO\nreduce\tO\nsynovitis\tB-Disease\n,\tO\nbut\tO\ndisease\tO\nactivity\tO\nalmost\tO\nalways\tO\nrecurs\tO\nafter\tO\ntherapy\tO\nis\tO\nstopped\tO\n.\tO\n\nSince\tO\nadverse\tO\nreactions\tO\nare\tO\nfrequent\tO\n,\tO\nless\tO\nthan\tO\n50\tO\npercent\tO\nof\tO\npatients\tO\nare\tO\nable\tO\nto\tO\ncontinue\tO\na\tO\nparticular\tO\ndrug\tO\nfor\tO\nmore\tO\nthan\tO\none\tO\nyear\tO\n.\tO\n\nSince\tO\nit\tO\ntakes\tO\nthree\tO\nto\tO\n12\tO\nmonths\tO\nto\tO\nachieve\tO\nmaximal\tO\neffects\tO\n,\tO\nthose\tO\npatients\tO\nwho\tO\nare\tO\nunable\tO\nto\tO\ncontinue\tO\nthe\tO\ndrug\tO\nreceive\tO\nlittle\tO\nbenefit\tO\nfrom\tO\nit\tO\n.\tO\n\nPatients\tO\ntreated\tO\nwith\tO\nalkylating\tB-Chemical\nagents\tI-Chemical\nhave\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\ndevelopment\tO\nof\tO\nacute\tB-Disease\nnonlymphocytic\tI-Disease\nleukemia\tI-Disease\n,\tO\nand\tO\nboth\tO\nalkylating\tB-Chemical\nagents\tI-Chemical\nand\tO\nazathioprine\tB-Chemical\nare\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nnon\tB-Disease\n-\tI-Disease\nHodgkin\tI-Disease\n'\tI-Disease\ns\tI-Disease\nlymphoma\tI-Disease\n.\tO\n\nCyclophosphamide\tB-Chemical\ntherapy\tO\nincreases\tO\nthe\tO\nrisk\tO\nof\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nbladder\tI-Disease\n.\tO\n\nThere\tO\nhave\tO\nbeen\tO\nseveral\tO\nlong\tO\n-\tO\nterm\tO\nstudies\tO\nof\tO\npatients\tO\nwith\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\ntreated\tO\nwith\tO\nazathioprine\tB-Chemical\nand\tO\ncyclophosphamide\tB-Chemical\nand\tO\nthe\tO\nincidence\tO\nof\tO\nmost\tO\nof\tO\nthe\tO\ncommon\tO\ncancers\tB-Disease\nis\tO\nnot\tO\nincreased\tO\n.\tO\n\nData\tO\non\tO\nthe\tO\npossible\tO\nincreased\tO\nrisk\tO\nof\tO\nmalignancy\tB-Disease\nin\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\nare\tO\nstill\tO\nbeing\tO\ncollected\tO\n,\tO\nand\tO\nuntil\tO\nfurther\tO\ninformation\tO\nis\tO\navailable\tO\n,\tO\nthe\tO\nuse\tO\nof\tO\nimmunosuppressive\tO\ndrugs\tO\n,\tO\nparticularly\tO\nalkylating\tB-Chemical\nagents\tI-Chemical\n,\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\nshould\tO\nbe\tO\nreserved\tO\nfor\tO\npatients\tO\nwith\tO\nsevere\tO\nprogressive\tO\ndisease\tO\nor\tO\nlife\tO\n-\tO\nthreatening\tO\ncomplications\tO\n.\tO\n\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\niliopsoas\tO\nhemorrhage\tB-Disease\nwith\tO\nsubsequent\tO\nfemoral\tB-Disease\nnerve\tI-Disease\npalsy\tI-Disease\n.\tO\n\nWe\tO\npresent\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n28\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\non\tO\nchronic\tO\nwarfarin\tB-Chemical\ntherapy\tO\nwho\tO\nsustained\tO\na\tO\nminor\tO\nmuscle\tB-Disease\ntear\tI-Disease\nand\tO\ndeveloped\tO\nincreasing\tO\npain\tB-Disease\nand\tO\na\tO\nflexure\tO\ncontracture\tB-Disease\nof\tO\nthe\tO\nright\tO\nhip\tO\n.\tO\n\nSurgical\tO\nexploration\tO\nrevealed\tO\nan\tO\niliopsoas\tO\nhematoma\tB-Disease\nand\tO\nfemoral\tO\nnerve\tB-Disease\nentrapment\tI-Disease\n,\tO\nresulting\tO\nin\tO\na\tO\nfemoral\tB-Disease\nnerve\tI-Disease\npalsy\tI-Disease\nand\tO\npartial\tB-Disease\nloss\tI-Disease\nof\tI-Disease\nquadriceps\tI-Disease\nfunctions\tI-Disease\n.\tO\n\nAnticoagulant\tO\n-\tO\ninduced\tO\nfemoral\tB-Disease\nnerve\tI-Disease\npalsy\tI-Disease\nrepresents\tO\nthe\tO\nmost\tO\ncommon\tO\nform\tO\nof\tO\nwarfarin\tB-Chemical\n-\tO\ninduced\tO\nperipheral\tB-Disease\nneuropathy\tI-Disease\n;\tO\nit\tO\nis\tO\ncharacterized\tO\nby\tO\nsevere\tO\npain\tB-Disease\nin\tO\nthe\tO\ninguinal\tO\nregion\tO\n,\tO\nvarying\tO\ndegrees\tO\nof\tO\nmotor\tB-Disease\nand\tI-Disease\nsensory\tI-Disease\nimpairment\tI-Disease\n,\tO\nand\tO\nflexure\tO\ncontracture\tB-Disease\nof\tO\nthe\tO\ninvolved\tO\nextremity\tO\n.\tO\n\nPneumonitis\tO\nwith\tO\npleural\tB-Disease\nand\tI-Disease\npericardial\tI-Disease\neffusion\tI-Disease\nand\tO\nneuropathy\tB-Disease\nduring\tO\namiodarone\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\npatient\tO\nwith\tO\nsinuatrial\tB-Disease\ndisease\tI-Disease\nand\tO\nimplanted\tO\npacemaker\tO\nwas\tO\ntreated\tO\nwith\tO\namiodarone\tB-Chemical\n(\tO\nmaximum\tO\ndose\tO\n1000\tO\nmg\tO\n,\tO\nmaintenance\tO\ndose\tO\n800\tO\nmg\tO\ndaily\tO\n)\tO\nfor\tO\n10\tO\nmonths\tO\n,\tO\nfor\tO\ncontrol\tO\nof\tO\nsupraventricular\tB-Disease\ntachyarrhythmias\tI-Disease\n.\tO\n\nHe\tO\ndeveloped\tO\npneumonitis\tB-Disease\n,\tO\npleural\tB-Disease\nand\tI-Disease\npericardial\tI-Disease\neffusions\tI-Disease\n,\tO\nand\tO\na\tO\npredominantly\tO\nproximal\tB-Disease\nmotor\tI-Disease\nneuropathy\tI-Disease\n.\tO\n\nImmediate\tO\nbut\tO\ngradual\tO\nimprovement\tO\nfollowed\tO\nwithdrawal\tO\nof\tO\namiodarone\tB-Chemical\nand\tO\ntreatment\tO\nwith\tO\nprednisolone\tB-Chemical\n.\tO\n\nReview\tO\nof\tO\nthis\tO\nand\tO\npreviously\tO\nreported\tO\ncases\tO\nindicates\tO\nthe\tO\nneed\tO\nfor\tO\nearly\tO\ndiagnosis\tO\nof\tO\namiodarone\tB-Chemical\npneumonitis\tB-Disease\n,\tO\nimmediate\tO\nwithdrawal\tO\nof\tO\namiodarone\tB-Chemical\n,\tO\nand\tO\nprompt\tO\nbut\tO\ncontinued\tO\nsteroid\tB-Chemical\ntherapy\tO\nto\tO\nensure\tO\nfull\tO\nrecovery\tO\n.\tO\n\nAmiodarone\tB-Chemical\n-\tO\ninduced\tO\nsinoatrial\tB-Disease\nblock\tI-Disease\n.\tO\n\nWe\tO\nobserved\tO\nsinoatrial\tB-Disease\nblock\tI-Disease\ndue\tO\nto\tO\nchronic\tO\namiodarone\tB-Chemical\nadministration\tO\nin\tO\na\tO\n5\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwith\tO\nprimary\tB-Disease\ncardiomyopathy\tI-Disease\n,\tO\nWolff\tB-Disease\n-\tI-Disease\nParkinson\tI-Disease\n-\tI-Disease\nWhite\tI-Disease\nsyndrome\tI-Disease\nand\tO\nsupraventricular\tB-Disease\ntachycardia\tI-Disease\n.\tO\n\nReduction\tO\nin\tO\nthe\tO\ndosage\tO\nof\tO\namiodarone\tB-Chemical\nresulted\tO\nin\tO\nthe\tO\ndisappearance\tO\nof\tO\nthe\tO\nsinoatrial\tB-Disease\nblock\tI-Disease\nand\tO\nthe\tO\npersistence\tO\nof\tO\nasymptomatic\tO\nsinus\tB-Disease\nbradycardia\tI-Disease\n.\tO\n\nDesipramine\tB-Chemical\n-\tO\ninduced\tO\ndelirium\tB-Disease\nat\tO\n\"\tO\nsubtherapeutic\tO\n\"\tO\nconcentrations\tO\n:\tO\na\tO\ncase\tO\nreport\tO\n.\tO\n\nAn\tO\nelderly\tO\npatient\tO\ntreated\tO\nwith\tO\nlow\tO\ndose\tO\nDesipramine\tB-Chemical\ndeveloped\tO\na\tO\ndelirium\tB-Disease\nwhile\tO\nher\tO\nplasma\tO\nlevel\tO\nwas\tO\nin\tO\nthe\tO\n\"\tO\nsubtherapeutic\tO\n\"\tO\nrange\tO\n.\tO\n\nDelirium\tB-Disease\n,\tO\nwhich\tO\nmay\tO\nbe\tO\ninduced\tO\nby\tO\ntricyclic\tO\ndrug\tO\ntherapy\tO\nin\tO\nthe\tO\nelderly\tO\n,\tO\ncan\tO\nbe\tO\ncaused\tO\nby\tO\ntricyclics\tO\nwith\tO\nlow\tO\nanticholinergic\tO\npotency\tO\n.\tO\n\nTherapeutic\tO\nranges\tO\nfor\tO\nantidepressants\tB-Chemical\nthat\tO\nhave\tO\nbeen\tO\nderived\tO\nfrom\tO\ngeneral\tO\nadult\tO\npopulation\tO\nstudies\tO\nmay\tO\nnot\tO\nbe\tO\nappropriate\tO\nfor\tO\nthe\tO\nelderly\tO\n.\tO\n\nFurther\tO\nstudies\tO\nof\tO\nspecifically\tO\nelderly\tO\npatients\tO\nare\tO\nnow\tO\nrequired\tO\nto\tO\nestablish\tO\nsafer\tO\nand\tO\nmore\tO\nappropriate\tO\nguidelines\tO\nfor\tO\ndrug\tO\ntherapy\tO\n.\tO\n\nIndomethacin\tB-Chemical\n-\tO\ninduced\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\n:\tO\nrecurrence\tO\non\tO\nrechallenge\tO\n.\tO\n\nWe\tO\nhave\tO\nreported\tO\na\tO\ncase\tO\nof\tO\nacute\tO\noliguric\tO\nrenal\tB-Disease\nfailure\tI-Disease\nwith\tO\nhyperkalemia\tB-Disease\nin\tO\na\tO\npatient\tO\nwith\tO\ncirrhosis\tB-Disease\n,\tO\nascites\tB-Disease\n,\tO\nand\tO\ncor\tB-Disease\npulmonale\tI-Disease\nafter\tO\nindomethacin\tB-Chemical\ntherapy\tO\n.\tO\n\nPrompt\tO\nrestoration\tO\nof\tO\nrenal\tO\nfunction\tO\nfollowed\tO\ndrug\tO\nwithdrawal\tO\n,\tO\nwhile\tO\nre\tO\n-\tO\nexposure\tO\nto\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\nindomethacin\tB-Chemical\ncaused\tO\nrecurrence\tO\nof\tO\nacute\tO\nreversible\tO\noliguria\tB-Disease\n.\tO\n\nOur\tO\ncase\tO\nsupports\tO\nthe\tO\nhypothesis\tO\nthat\tO\nendogenous\tO\nrenal\tO\nprostaglandins\tB-Chemical\nplay\tO\na\tO\nrole\tO\nin\tO\nthe\tO\nmaintenance\tO\nof\tO\nrenal\tO\nblood\tO\nflow\tO\nwhen\tO\ncirculating\tO\nplasma\tO\nvolume\tO\nis\tO\ndiminished\tO\n.\tO\n\nSince\tO\nnonsteroidal\tO\nanti\tO\n-\tO\ninflammatory\tO\nagents\tO\ninterfere\tO\nwith\tO\nthis\tO\ncompensatory\tO\nmechanism\tO\nand\tO\nmay\tO\ncause\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nthey\tO\nshould\tO\nbe\tO\nused\tO\nwith\tO\ncaution\tO\nin\tO\nsuch\tO\npatients\tO\n.\tO\n\nPatterns\tO\nof\tO\nhepatic\tB-Disease\ninjury\tI-Disease\ninduced\tO\nby\tO\nmethyldopa\tB-Chemical\n.\tO\n\nTwelve\tO\npatients\tO\nwith\tO\nliver\tB-Disease\ndisease\tI-Disease\nrelated\tO\nto\tO\nmethyldopa\tB-Chemical\nwere\tO\nseen\tO\nbetween\tO\n1967\tO\nand\tO\n1977\tO\n.\tO\n\nIllness\tO\noccurred\tO\nwithin\tO\n1\tO\n-\tO\n-\tO\n9\tO\nweeks\tO\nof\tO\ncommencement\tO\nof\tO\ntherapy\tO\nin\tO\n9\tO\npatients\tO\n,\tO\nthe\tO\nremaining\tO\n3\tO\npatients\tO\nhaving\tO\nreceived\tO\nthe\tO\ndrug\tO\nfor\tO\n13\tO\nmonths\tO\n,\tO\n15\tO\nmonths\tO\nand\tO\n7\tO\nyears\tO\nbefore\tO\nexperiencing\tO\nsymptoms\tO\n.\tO\n\nJaundice\tB-Disease\nwith\tO\ntender\tO\nhepatomegaly\tB-Disease\n,\tO\nusually\tO\npreceded\tO\nby\tO\nsymptoms\tO\nof\tO\nmalaise\tO\n,\tO\nanorexia\tB-Disease\n,\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\n,\tO\nand\tO\nassociated\tO\nwith\tO\nupper\tO\nabdominal\tB-Disease\npain\tI-Disease\n,\tO\nwas\tO\nan\tO\ninvariable\tO\nfinding\tO\nin\tO\nall\tO\npatients\tO\n.\tO\n\nBiochemical\tO\nliver\tO\nfunction\tO\ntests\tO\nindicated\tO\nhepatocellular\tO\nnecrosis\tB-Disease\nand\tO\ncorrelated\tO\nwith\tO\nhistopathological\tO\nevidence\tO\nof\tO\nhepatic\tB-Disease\ninjury\tI-Disease\n,\tO\nthe\tO\nspectrum\tO\nof\tO\nwhich\tO\nranged\tO\nfrom\tO\nfatty\tB-Disease\nchange\tI-Disease\nand\tO\nfocal\tO\nhepatocellular\tO\nnecrosis\tB-Disease\nto\tO\nmassive\tB-Disease\nhepatic\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nMost\tO\npatients\tO\nshowed\tO\nmoderate\tO\nto\tO\nsevere\tO\nacute\tB-Disease\nhepatitis\tI-Disease\nor\tO\nchronic\tB-Disease\nactive\tI-Disease\nhepatitis\tI-Disease\nwith\tO\nassociated\tO\ncholestasis\tB-Disease\n.\tO\n\nThe\tO\ndrug\tO\nwas\tO\nwithdrawn\tO\non\tO\npresentation\tO\nto\tO\nhospital\tO\nin\tO\n11\tO\npatients\tO\n,\tO\nwith\tO\nrapid\tO\nclinical\tO\nimprovement\tO\nin\tO\n9\tO\n.\tO\n\nOne\tO\npatient\tO\ndied\tO\n,\tO\nhaving\tO\npresented\tO\nin\tO\nhepatic\tB-Disease\nfailure\tI-Disease\n,\tO\nand\tO\nanother\tO\n,\tO\nwho\tO\nhad\tO\nbeen\tO\ntaking\tO\nmethyldopa\tB-Chemical\nfor\tO\n7\tO\nyears\tO\n,\tO\nshowed\tO\nslower\tO\nclinical\tO\nand\tO\nbiochemical\tO\nresolution\tO\nover\tO\na\tO\nperiod\tO\nof\tO\nseveral\tO\nmonths\tO\n.\tO\n\nThe\tO\nremaining\tO\npatient\tO\nin\tO\nthe\tO\nseries\tO\ndeveloped\tO\nfulminant\tB-Disease\nhepatitis\tI-Disease\nwhen\tO\nthe\tO\ndrug\tO\nwas\tO\naccidentally\tO\nrecommenced\tO\n1\tO\nyear\tO\nafter\tO\na\tO\nprior\tO\nepisode\tO\nof\tO\nmethyldopa\tB-Chemical\n-\tO\ninduced\tO\nhepatitis\tB-Disease\n.\tO\n\nIn\tO\nthis\tO\nlatter\tO\npatient\tO\n,\tO\nand\tO\nin\tO\n2\tO\nothers\tO\n,\tO\nthe\tO\ncausal\tO\nrelationship\tO\nbetween\tO\nmethyldopa\tB-Chemical\nand\tO\nhepatic\tB-Disease\ndysfunction\tI-Disease\nwas\tO\nproved\tO\nwith\tO\nthe\tO\nrecurrence\tO\nof\tO\nhepatitis\tB-Disease\nwithin\tO\n2\tO\nweeks\tO\nof\tO\nre\tO\n-\tO\nexposure\tO\nto\tO\nthe\tO\ndrug\tO\n.\tO\n\nSuxamethonium\tB-Chemical\ninfusion\tO\nrate\tO\nand\tO\nobserved\tO\nfasciculations\tB-Disease\n.\tO\n\nA\tO\ndose\tO\n-\tO\nresponse\tO\nstudy\tO\n.\tO\n\nSuxamethonium\tB-Chemical\nchloride\tI-Chemical\n(\tO\nSch\tB-Chemical\n)\tO\nwas\tO\nadministered\tO\ni\tO\n.\tO\nv\tO\n.\tO\nto\tO\n36\tO\nadult\tO\nmales\tO\nat\tO\nsix\tO\nrates\tO\n:\tO\n0\tO\n.\tO\n25\tO\nmg\tO\ns\tO\n-\tO\n1\tO\nto\tO\n20\tO\nmg\tO\ns\tO\n-\tO\n1\tO\n.\tO\n\nThe\tO\ninfusion\tO\nwas\tO\ndiscontinued\tO\neither\tO\nwhen\tO\nthere\tO\nwas\tO\nno\tO\nmuscular\tO\nresponse\tO\nto\tO\ntetanic\tB-Disease\nstimulation\tO\nof\tO\nthe\tO\nulnar\tO\nnerve\tO\nor\tO\nwhen\tO\nSch\tB-Chemical\n120\tO\nmg\tO\nwas\tO\nexceeded\tO\n.\tO\n\nSix\tO\nadditional\tO\npatients\tO\nreceived\tO\na\tO\n30\tO\n-\tO\nmg\tO\ni\tO\n.\tO\nv\tO\n.\tO\nbolus\tO\ndose\tO\n.\tO\n\nFasciculations\tB-Disease\nin\tO\nsix\tO\nareas\tO\nof\tO\nthe\tO\nbody\tO\nwere\tO\nscored\tO\nfrom\tO\n0\tO\nto\tO\n3\tO\nand\tO\nsummated\tO\nas\tO\na\tO\ntotal\tO\nfasciculation\tB-Disease\nscore\tO\n.\tO\n\nThe\tO\ntimes\tO\nto\tO\nfirst\tO\nfasciculation\tB-Disease\n,\tO\ntwitch\tB-Disease\nsuppression\tO\nand\tO\ntetanus\tB-Disease\nsuppression\tO\nwere\tO\ninversely\tO\nrelated\tO\nto\tO\nthe\tO\ninfusion\tO\nrates\tO\n.\tO\n\nFasciculations\tB-Disease\nin\tO\nthe\tO\nsix\tO\nareas\tO\nand\tO\nthe\tO\ntotal\tO\nfasciculation\tB-Disease\nscore\tO\nwere\tO\nrelated\tO\ndirectly\tO\nto\tO\nthe\tO\nrate\tO\nof\tO\ninfusion\tO\n.\tO\n\nTotal\tO\nfasciculation\tB-Disease\nscores\tO\nin\tO\nthe\tO\n30\tO\n-\tO\nmg\tO\nbolus\tO\ngroup\tO\nand\tO\nthe\tO\n5\tO\n-\tO\nmg\tO\ns\tO\n-\tO\n1\tO\nand\tO\n20\tO\n-\tO\nmg\tO\ns\tO\n-\tO\n1\tO\ninfusion\tO\ngroups\tO\nwere\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\n.\tO\n\nTreatment\tO\nof\tO\npsoriasis\tB-Disease\nwith\tO\nazathioprine\tB-Chemical\n.\tO\n\nAzathioprine\tB-Chemical\ntreatment\tO\nbenefited\tO\n19\tO\n(\tO\n66\tO\n%\tO\n)\tO\nout\tO\nof\tO\n29\tO\npatients\tO\nsuffering\tO\nfrom\tO\nsevere\tO\npsoriasis\tB-Disease\n.\tO\n\nHaematological\tO\ncomplications\tO\nwere\tO\nnot\tO\ntroublesome\tO\nand\tO\nresults\tO\nof\tO\nbiochemical\tO\nliver\tO\nfunction\tO\ntests\tO\nremained\tO\nnormal\tO\n.\tO\n\nMinimal\tO\ncholestasis\tB-Disease\nwas\tO\nseen\tO\nin\tO\ntwo\tO\ncases\tO\nand\tO\nportal\tO\nfibrosis\tB-Disease\nof\tO\na\tO\nreversible\tO\ndegree\tO\nin\tO\neight\tO\n.\tO\n\nLiver\tO\nbiopsies\tO\nshould\tO\nbe\tO\nundertaken\tO\nat\tO\nregular\tO\nintervals\tO\nif\tO\nazathioprine\tB-Chemical\ntherapy\tO\nis\tO\ncontinued\tO\nso\tO\nthat\tO\nstructural\tO\nliver\tB-Disease\ndamage\tI-Disease\nmay\tO\nbe\tO\ndetected\tO\nat\tO\nan\tO\nearly\tO\nand\tO\nreversible\tO\nstage\tO\n.\tO\n\nAngiosarcoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nliver\tI-Disease\nassociated\tO\nwith\tO\ndiethylstilbestrol\tB-Chemical\n.\tO\n\nAngiosarcoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nliver\tI-Disease\noccurred\tO\nin\tO\na\tO\n76\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\nhad\tO\nbeen\tO\ntreated\tO\nfor\tO\na\tO\nwell\tO\n-\tO\ndifferentiated\tO\nadenocarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nliver\tI-Disease\nwith\tO\ndiethylstilbestrol\tB-Chemical\nfor\tO\n13\tO\nyears\tO\n.\tO\n\nAngiosarcoma\tB-Disease\nwas\tO\nalso\tO\npresent\tO\nwithin\tO\npulmonary\tO\nand\tO\nrenal\tO\narteries\tO\n.\tO\n\nThe\tO\npossibility\tO\nthat\tO\nthe\tO\nintraarterial\tB-Disease\nlesions\tI-Disease\nmight\tO\nrepresent\tO\nindependent\tO\nprimary\tO\ntumors\tB-Disease\nis\tO\nconsidered\tO\n.\tO\n\nGalanthamine\tB-Chemical\nhydrobromide\tI-Chemical\n,\tO\na\tO\nlonger\tO\nacting\tO\nanticholinesterase\tO\ndrug\tO\n,\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nthe\tO\ncentral\tO\neffects\tO\nof\tO\nscopolamine\tB-Chemical\n(\tO\nHyoscine\tB-Chemical\n)\tO\n.\tO\n\nGalanthamine\tB-Chemical\nhydrobromide\tI-Chemical\n,\tO\nan\tO\nanticholinesterase\tO\ndrug\tO\ncapable\tO\nof\tO\npenetrating\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n,\tO\nwas\tO\nused\tO\nin\tO\na\tO\npatient\tO\ndemonstrating\tO\ncentral\tO\neffects\tO\nof\tO\nscopolamine\tB-Chemical\n(\tO\nhyoscine\tB-Chemical\n)\tO\noverdosage\tB-Disease\n.\tO\n\nIt\tO\nis\tO\nlonger\tO\nacting\tO\nthan\tO\nphysostigmine\tB-Chemical\nand\tO\nis\tO\nused\tO\nin\tO\nanaesthesia\tO\nto\tO\nreverse\tO\nthe\tO\nnon\tO\n-\tO\ndepolarizing\tO\nneuromuscular\tO\nblock\tO\n.\tO\n\nHowever\tO\n,\tO\nstudies\tO\ninto\tO\nthe\tO\ndose\tO\nnecessary\tO\nto\tO\ncombating\tO\nscopolamine\tB-Chemical\nintoxication\tO\nare\tO\nindicated\tO\n.\tO\n\nComparison\tO\nof\tO\nthe\tO\nsubjective\tO\neffects\tO\nand\tO\nplasma\tO\nconcentrations\tO\nfollowing\tO\noral\tO\nand\tO\ni\tO\n.\tO\nm\tO\n.\tO\nadministration\tO\nof\tO\nflunitrazepam\tB-Chemical\nin\tO\nvolunteers\tO\n.\tO\n\nFlunitrazepam\tB-Chemical\n0\tO\n.\tO\n5\tO\n,\tO\n1\tO\n.\tO\n0\tO\nor\tO\n2\tO\n.\tO\n0\tO\nmg\tO\nwas\tO\ngiven\tO\nby\tO\nthe\tO\noral\tO\nor\tO\ni\tO\n.\tO\nm\tO\n.\tO\nroutes\tO\nto\tO\ngroups\tO\nof\tO\nvolunteers\tO\nand\tO\nits\tO\neffects\tO\ncompared\tO\n.\tO\n\nPlasma\tO\nconcentrations\tO\nof\tO\nthe\tO\ndrug\tO\nwere\tO\nestimated\tO\nby\tO\ngas\tO\n-\tO\nliquid\tO\nchromatography\tO\n,\tO\nin\tO\na\tO\nsmaller\tO\nnumber\tO\nof\tO\nthe\tO\nsubjects\tO\n.\tO\n\nThe\tO\nmost\tO\nstriking\tO\neffect\tO\nwas\tO\nsedation\tO\nwhich\tO\nincreased\tO\nwith\tO\nthe\tO\ndose\tO\n,\tO\n2\tO\nmg\tO\nproducing\tO\ndeep\tO\nsleep\tO\nalthough\tO\nthe\tO\nsubjects\tO\ncould\tO\nstill\tO\nbe\tO\naroused\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\ni\tO\n.\tO\nm\tO\n.\tO\nadministration\tO\nwere\tO\napparent\tO\nearlier\tO\nand\tO\nsometimes\tO\nlasted\tO\nlonger\tO\nthan\tO\nthose\tO\nfollowing\tO\noral\tO\nadministration\tO\n.\tO\n\nDizziness\tB-Disease\nwas\tO\nless\tO\nmarked\tO\nthan\tO\nsedation\tO\n,\tO\nbut\tO\nincreased\tO\nwith\tO\nthe\tO\ndose\tO\n.\tO\n\nThere\tO\nwas\tO\npain\tB-Disease\non\tO\ni\tO\n.\tO\nm\tO\n.\tO\ninjection\tO\nof\tO\nflunitrazepam\tB-Chemical\nsignificantly\tO\nmore\tO\noften\tO\nthan\tO\nwith\tO\nisotonic\tO\nsaline\tO\n.\tO\n\nPlasma\tO\nconcentrations\tO\nvaried\tO\nwith\tO\ndose\tO\nand\tO\nroute\tO\nand\tO\ncorresponded\tO\nqualitatively\tO\nwith\tO\nthe\tO\nsubjective\tO\neffects\tO\n.\tO\n\nThe\tO\ndrug\tO\nwas\tO\nstill\tO\npresent\tO\nin\tO\nmeasurable\tO\nquantities\tO\nafter\tO\n24\tO\nh\tO\neven\tO\nwith\tO\nthe\tO\nsmallest\tO\ndose\tO\n.\tO\n\nPossible\tO\nteratogenicity\tO\nof\tO\nsulphasalazine\tB-Chemical\n.\tO\n\nThree\tO\ninfants\tO\n,\tO\nborn\tO\nof\tO\ntwo\tO\nmothers\tO\nwith\tO\ninflammatory\tB-Disease\nbowel\tI-Disease\ndisease\tI-Disease\nwho\tO\nreceived\tO\ntreatment\tO\nwith\tO\nsulphasalazine\tB-Chemical\nthroughout\tO\npregnancy\tO\n,\tO\nwere\tO\nfound\tO\nto\tO\nhave\tO\nmajor\tO\ncongenital\tB-Disease\nanomalies\tI-Disease\n.\tO\n\nIn\tO\nthe\tO\nsingleton\tO\npregnancy\tO\n,\tO\nthe\tO\nmother\tO\nhad\tO\nulcerative\tB-Disease\ncolitis\tI-Disease\n,\tO\nand\tO\nthe\tO\ninfant\tO\n,\tO\na\tO\nmale\tO\n,\tO\nhad\tO\ncoarctation\tB-Disease\nof\tI-Disease\nthe\tI-Disease\naorta\tI-Disease\nand\tO\na\tO\nventricular\tB-Disease\nseptal\tI-Disease\ndefect\tI-Disease\n.\tO\n\nIn\tO\nthe\tO\ntwin\tO\npregnancy\tO\n,\tO\nthe\tO\nmother\tO\nhad\tO\nCrohn\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nThe\tO\nfirst\tO\ntwin\tO\n,\tO\na\tO\nfemale\tO\n,\tO\nhad\tO\na\tO\nleft\tO\nPotter\tB-Disease\n-\tI-Disease\ntype\tI-Disease\nIIa\tI-Disease\npolycystic\tI-Disease\nkidney\tI-Disease\nand\tO\na\tO\nrudimentary\tB-Disease\nleft\tI-Disease\nuterine\tI-Disease\ncornu\tI-Disease\n.\tO\n\nThe\tO\nsecond\tO\ntwin\tO\n,\tO\na\tO\nmale\tO\n,\tO\nhad\tO\nsome\tO\nfeatures\tO\nof\tO\nPotter\tB-Disease\n'\tI-Disease\ns\tI-Disease\nfacies\tI-Disease\n,\tO\nhypoplastic\tB-Disease\nlungs\tI-Disease\n,\tO\nabsent\tB-Disease\nkidneys\tI-Disease\nand\tI-Disease\nureters\tI-Disease\n,\tO\nand\tO\ntalipes\tB-Disease\nequinovarus\tI-Disease\n.\tO\n\nDespite\tO\nreports\tO\nto\tO\nthe\tO\ncontrary\tO\n,\tO\nit\tO\nis\tO\nsuggested\tO\nthat\tO\nsulphasalazine\tB-Chemical\nmay\tO\nbe\tO\nteratogenic\tO\n.\tO\n\nThrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nand\tO\nrenal\tB-Disease\nfailure\tI-Disease\nassociated\tO\nwith\tO\nantineoplastic\tO\nchemotherapy\tO\n.\tO\n\nFive\tO\npatients\tO\nwith\tO\ncarcinoma\tB-Disease\ndeveloped\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n(\tO\ncharacterized\tO\nby\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\n,\tO\nmicroangiopathic\tB-Disease\nhemolytic\tI-Disease\nanemia\tI-Disease\n,\tO\nand\tO\nusually\tO\nthrombocytopenia\tB-Disease\n)\tO\nafter\tO\ntreatment\tO\nwith\tO\ncisplatin\tB-Chemical\n,\tO\nbleomycin\tB-Chemical\n,\tO\nand\tO\na\tO\nvinca\tB-Chemical\nalkaloid\tI-Chemical\n.\tO\n\nOne\tO\npatient\tO\nhad\tO\nthrombotic\tB-Disease\nthrombocytopenic\tI-Disease\npurpura\tI-Disease\n,\tO\nthree\tO\nthe\tO\nhemolytic\tB-Disease\n-\tI-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\n,\tO\nand\tO\none\tO\nan\tO\napparent\tO\nforme\tO\nfruste\tO\nof\tO\none\tO\nof\tO\nthese\tO\ndisorders\tO\n.\tO\n\nHistologic\tO\nexamination\tO\nof\tO\nthe\tO\nrenal\tO\ntissue\tO\nshowed\tO\nevidence\tO\nof\tO\nintravascular\tB-Disease\ncoagulation\tI-Disease\n,\tO\nprimarily\tO\naffecting\tO\nthe\tO\nsmall\tO\narteries\tO\n,\tO\narterioles\tO\n,\tO\nand\tO\nglomeruli\tO\n.\tO\n\nBecause\tO\neach\tO\npatient\tO\nwas\tO\ntumor\tB-Disease\n-\tO\nfree\tO\nor\tO\nhad\tO\nonly\tO\na\tO\nsmall\tO\ntumor\tB-Disease\nat\tO\nthe\tO\nonset\tO\nof\tO\nthis\tO\nsyndrome\tO\n,\tO\nthe\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\nmay\tO\nhave\tO\nbeen\tO\ninduced\tO\nby\tO\nchemotherapy\tO\n.\tO\n\nDiagnosis\tO\nof\tO\nthis\tO\npotentially\tO\nfatal\tO\ncomplication\tO\nmay\tO\nbe\tO\ndelayed\tO\nor\tO\nmissed\tO\nif\tO\nrenal\tO\ntissue\tO\nor\tO\nthe\tO\nperipheral\tO\nblood\tO\nsmear\tO\nis\tO\nnot\tO\nexamined\tO\n,\tO\nbecause\tO\nrenal\tB-Disease\nfailure\tI-Disease\nmay\tO\nbe\tO\nascribed\tO\nto\tO\ncisplatin\tB-Chemical\nnephrotoxicity\tB-Disease\nand\tO\nthe\tO\nanemia\tB-Disease\nand\tO\nthrombocytopenia\tB-Disease\nto\tO\ndrug\tO\n-\tO\ninduced\tO\nbone\tB-Disease\nmarrow\tI-Disease\nsuppression\tI-Disease\n.\tO\n\nInternational\tO\nmexiletine\tB-Chemical\nand\tO\nplacebo\tO\nantiarrhythmic\tO\ncoronary\tO\ntrial\tO\n:\tO\nI\tO\n.\tO\n\nReport\tO\non\tO\narrhythmia\tB-Disease\nand\tO\nother\tO\nfindings\tO\n.\tO\n\nImpact\tO\nResearch\tO\nGroup\tO\n.\tO\n\nThe\tO\nantiarrhythmic\tO\neffects\tO\nof\tO\nthe\tO\nsustained\tO\nrelease\tO\nform\tO\nof\tO\nmexiletine\tB-Chemical\n(\tO\nMexitil\tB-Chemical\n-\tI-Chemical\nPerlongets\tI-Chemical\n)\tO\nwere\tO\nevaluated\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\nplacebo\tO\ntrial\tO\nin\tO\n630\tO\npatients\tO\nwith\tO\nrecent\tO\ndocumented\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nThe\tO\nprimary\tO\nresponse\tO\nvariable\tO\nwas\tO\nbased\tO\non\tO\ncentral\tO\nreading\tO\nof\tO\n24\tO\nhour\tO\nambulatory\tO\nelectrocardiographic\tO\nrecordings\tO\nand\tO\nwas\tO\ndefined\tO\nas\tO\nthe\tO\noccurrence\tO\nof\tO\n30\tO\nor\tO\nmore\tO\nsingle\tO\npremature\tO\nventricular\tO\ncomplexes\tO\nin\tO\nany\tO\ntwo\tO\nconsecutive\tO\n30\tO\nminute\tO\nblocks\tO\nor\tO\none\tO\nor\tO\nmore\tO\nruns\tO\nof\tO\ntwo\tO\nor\tO\nmore\tO\npremature\tO\nventricular\tO\ncomplexes\tO\nin\tO\nthe\tO\nentire\tO\n24\tO\nhour\tO\nelectrocardiographic\tO\nrecording\tO\n.\tO\n\nLarge\tO\ndifferences\tO\n,\tO\nregarded\tO\nas\tO\nstatistically\tO\nsignificant\tO\n,\tO\nbetween\tO\nthe\tO\nmexiletine\tB-Chemical\nand\tO\nplacebo\tO\ngroups\tO\nwere\tO\nnoted\tO\nin\tO\nthat\tO\nend\tO\npoint\tO\nat\tO\nmonths\tO\n1\tO\nand\tO\n4\tO\n,\tO\nbut\tO\nonly\tO\ntrends\tO\nwere\tO\nobserved\tO\nat\tO\nmonth\tO\n12\tO\n.\tO\n\nThese\tO\ndifferences\tO\nwere\tO\nobserved\tO\neven\tO\nthough\tO\nthe\tO\nserum\tO\nmexiletine\tB-Chemical\nlevels\tO\nobtained\tO\nin\tO\nthis\tO\nstudy\tO\nwere\tO\ngenerally\tO\nlower\tO\nthan\tO\nthose\tO\nobserved\tO\nin\tO\nstudies\tO\nthat\tO\nhave\tO\nused\tO\nthe\tO\nregular\tO\nform\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nThere\tO\nwere\tO\nmore\tO\ndeaths\tB-Disease\nin\tO\nthe\tO\nmexiletine\tB-Chemical\ngroup\tO\n(\tO\n7\tO\n.\tO\n6\tO\n%\tO\n)\tO\nthan\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\n(\tO\n4\tO\n.\tO\n8\tO\n%\tO\n)\tO\n;\tO\nthe\tO\ndifference\tO\nwas\tO\nnot\tO\nstatistically\tO\nsignificant\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\ncoronary\tO\nevents\tO\nwas\tO\nsimilar\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nPreviously\tO\nrecognized\tO\nside\tO\neffects\tO\n,\tO\nparticularly\tO\ntremor\tB-Disease\nand\tO\ngastrointestinal\tB-Disease\nproblems\tI-Disease\n,\tO\nwere\tO\nmore\tO\nfrequent\tO\nin\tO\nthe\tO\nmexiletine\tB-Chemical\ngroup\tO\nthan\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\n.\tO\n\nChanges\tO\nin\tO\nheart\tO\nsize\tO\nduring\tO\nlong\tO\n-\tO\nterm\tO\ntimolol\tB-Chemical\ntreatment\tO\nafter\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\ntimolol\tB-Chemical\ntreatment\tO\non\tO\nheart\tO\nsize\tO\nafter\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nevaluated\tO\nby\tO\nX\tO\n-\tO\nray\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\nincluding\tO\n241\tO\npatients\tO\n(\tO\nplacebo\tO\n126\tO\n,\tO\ntimolol\tB-Chemical\n115\tO\n)\tO\n.\tO\n\nThe\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\nwas\tO\n12\tO\nmonths\tO\n.\tO\n\nThe\tO\ntimolol\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nshowed\tO\na\tO\nsmall\tO\nbut\tO\nsignificant\tO\nincrease\tO\nin\tO\nheart\tO\nsize\tO\nfrom\tO\nbaseline\tO\nin\tO\ncontrast\tO\nto\tO\na\tO\ndecrease\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\n.\tO\n\nThese\tO\ndifferences\tO\nmay\tO\nbe\tO\ncaused\tO\nby\tO\ntimolol\tB-Chemical\n-\tO\ninduced\tO\nbradycardia\tB-Disease\nand\tO\na\tO\ncompensatory\tO\nincrease\tO\nin\tO\nend\tO\n-\tO\ndiastolic\tO\nvolume\tO\n.\tO\n\nThe\tO\ntimolol\tB-Chemical\n-\tO\nrelated\tO\nincrease\tO\nin\tO\nheart\tO\nsize\tO\nwas\tO\nobserved\tO\nonly\tO\nin\tO\npatients\tO\nwith\tO\nnormal\tO\nand\tO\nborderline\tO\nheart\tO\nsize\tO\n.\tO\n\nIn\tO\npatients\tO\nwith\tO\ncardiomegaly\tB-Disease\n,\tO\nthe\tO\nincrease\tO\nin\tO\nheart\tO\nsize\tO\nwas\tO\nsimilar\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nAfter\tO\nre\tO\n-\tO\ninfarction\tB-Disease\n,\tO\nheart\tO\nsize\tO\nincreased\tO\nin\tO\nthe\tO\nplacebo\tO\ngroup\tO\nand\tO\nremained\tO\nunchanged\tO\nin\tO\nthe\tO\ntimolol\tB-Chemical\ngroup\tO\n.\tO\n\nVitamin\tB-Chemical\nD3\tI-Chemical\ntoxicity\tB-Disease\nin\tO\ndairy\tO\ncows\tO\n.\tO\n\nLarge\tO\nparenteral\tO\ndoses\tO\nof\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\n(\tO\n15\tO\nto\tO\n17\tO\n.\tO\n5\tO\nx\tO\n10\tO\n(\tO\n6\tO\n)\tO\nIU\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\n)\tO\nwere\tO\nassociated\tO\nwith\tO\nprolonged\tO\nhypercalcemia\tB-Disease\n,\tO\nhyperphosphatemia\tB-Disease\n,\tO\nand\tO\nlarge\tO\nincreases\tO\nof\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\nand\tO\nits\tO\nmetabolites\tO\nin\tO\nthe\tO\nblood\tO\nplasma\tO\nof\tO\nnonlactating\tO\nnonpregnant\tO\nand\tO\npregnant\tO\nJersey\tO\ncows\tO\n.\tO\n\nCalcium\tB-Chemical\nconcentrations\tO\n1\tO\nday\tO\npostpartum\tO\nwere\tO\nhigher\tO\nin\tO\ncows\tO\ntreated\tO\nwith\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\nabout\tO\n32\tO\ndays\tO\nprepartum\tO\n(\tO\n8\tO\n.\tO\n8\tO\nmg\tO\n/\tO\n100\tO\nml\tO\n)\tO\nthan\tO\nin\tO\ncontrol\tO\ncows\tO\n(\tO\n5\tO\n.\tO\n5\tO\nmg\tO\n/\tO\n100\tO\nml\tO\n)\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\ncows\tO\ntreated\tO\nwith\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\nshowed\tO\nsigns\tO\nof\tO\nmilk\tB-Disease\nfever\tI-Disease\nduring\tO\nthe\tO\nperipartal\tO\nperiod\tO\n;\tO\nhowever\tO\n,\tO\n22\tO\n%\tO\nof\tO\nthe\tO\ncontrol\tO\ncows\tO\ndeveloped\tO\nclinical\tO\nsigns\tO\nof\tO\nmilk\tB-Disease\nfever\tI-Disease\nduring\tO\nthis\tO\nperiod\tO\n.\tO\n\nSigns\tO\nof\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\ntoxicity\tB-Disease\nwere\tO\nnot\tO\nobserved\tO\nin\tO\nnonlactating\tO\nnonpregnant\tO\ncows\tO\n;\tO\nhowever\tO\n,\tO\npregnant\tO\ncows\tO\ncommonly\tO\ndeveloped\tO\nsevere\tO\nsigns\tO\nof\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\ntoxicity\tB-Disease\nand\tO\n10\tO\nof\tO\n17\tO\ncows\tO\ndied\tO\n.\tO\n\nThere\tO\nwas\tO\nwidespread\tO\nmetastatic\tO\ncalcification\tO\nin\tO\nthe\tO\ncows\tO\nthat\tO\ndied\tO\n.\tO\n\nBecause\tO\nof\tO\nthe\tO\nextreme\tO\ntoxicity\tB-Disease\nof\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\nin\tO\npregnant\tO\nJersey\tO\ncows\tO\nand\tO\nthe\tO\nlow\tO\nmargin\tO\nof\tO\nsafety\tO\nbetween\tO\ndoses\tO\nof\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\nthat\tO\nprevent\tO\nmilk\tB-Disease\nfever\tI-Disease\nand\tO\ndoses\tO\nthat\tO\ninduce\tO\nmilk\tB-Disease\nfever\tI-Disease\n,\tO\nwe\tO\nconcluded\tO\nthat\tO\nvitamin\tB-Chemical\nD3\tI-Chemical\ncannot\tO\nbe\tO\nused\tO\npractically\tO\nto\tO\nprevent\tO\nmilk\tB-Disease\nfever\tI-Disease\nwhen\tO\ninjected\tO\nseveral\tO\nweeks\tO\nprepartum\tO\n.\tO\n\nDiseases\tB-Disease\nof\tI-Disease\nperipheral\tI-Disease\nnerves\tI-Disease\nas\tO\nseen\tO\nin\tO\nthe\tO\nNigerian\tO\nAfrican\tO\n.\tO\n\nThe\tO\nanatomical\tO\nand\tO\naetiological\tO\ndiagnoses\tO\nof\tO\nperipheral\tB-Disease\nnerve\tI-Disease\ndisease\tI-Disease\nexcluding\tO\nits\tO\nprimary\tO\nbenign\tO\nand\tO\nmalignant\tO\ndisorders\tO\n,\tO\nas\tO\nseen\tO\nin\tO\n358\tO\nNigerians\tO\nare\tO\npresented\tO\n.\tO\n\nThere\tO\nis\tO\na\tO\nmale\tO\npreponderance\tO\nand\tO\nthe\tO\npeak\tO\nincidence\tO\nis\tO\nin\tO\nthe\tO\nfourth\tO\ndecade\tO\n.\tO\n\nSensori\tB-Disease\n-\tI-Disease\nmotor\tI-Disease\nneuropathy\tI-Disease\nwas\tO\nthe\tO\ncommonest\tO\npresentation\tO\n(\tO\n50\tO\n%\tO\n)\tO\n.\tO\n\nGuillain\tB-Disease\n-\tI-Disease\nBarr\tI-Disease\nsyndrome\tI-Disease\nwas\tO\nthe\tO\ncommonest\tO\nidentifiable\tO\ncause\tO\n(\tO\n15\tO\n.\tO\n6\tO\n%\tO\n)\tO\n,\tO\naccounting\tO\nfor\tO\nhalf\tO\nof\tO\nthe\tO\ncases\tO\nwith\tO\nmotor\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nPeripheral\tB-Disease\nneuropathy\tI-Disease\ndue\tO\nto\tO\nnutritional\tB-Disease\ndeficiency\tI-Disease\nof\tO\nthiamine\tB-Chemical\nand\tO\nriboflavin\tB-Chemical\nwas\tO\ncommon\tO\n(\tO\n10\tO\n.\tO\n1\tO\n%\tO\n)\tO\nand\tO\npresented\tO\nmainly\tO\nas\tO\nsensory\tO\nand\tO\nsensori\tB-Disease\n-\tI-Disease\nmotor\tI-Disease\nneuropathy\tI-Disease\n.\tO\n\nDiabetes\tB-Disease\nmellitus\tI-Disease\nwas\tO\nthe\tO\nmajor\tO\ncause\tO\nof\tO\nautonomic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nIsoniazid\tB-Chemical\nwas\tO\nthe\tO\nmost\tO\nfrequent\tO\nagent\tO\nin\tO\ndrug\tO\n-\tO\ninduced\tO\nneuropathy\tB-Disease\n.\tO\n\nMigraine\tB-Disease\n(\tO\n20\tO\n%\tO\n)\tO\nwas\tO\nnot\tO\nan\tO\nuncommon\tO\ncause\tO\nof\tO\ncranial\tB-Disease\nneuropathy\tI-Disease\nalthough\tO\nmalignancies\tB-Disease\narising\tO\nfrom\tO\nthe\tO\nreticuloendothelial\tO\nsystem\tO\nor\tO\nrelated\tO\nstructures\tO\nof\tO\nthe\tO\nhead\tO\nand\tO\nneck\tO\nwere\tO\nmore\tO\nfrequent\tO\n(\tO\n26\tO\n%\tO\n)\tO\n.\tO\n\nIn\tO\n26\tO\n.\tO\n5\tO\n%\tO\nof\tO\nall\tO\nthe\tO\ncases\tO\n,\tO\nthe\tO\naetiology\tO\nof\tO\nthe\tO\nneuropathy\tB-Disease\nwas\tO\nundetermined\tO\n.\tO\n\nHeredofamilial\tO\nand\tO\nconnective\tB-Disease\ntissue\tI-Disease\ndisorders\tI-Disease\nwere\tO\nrare\tO\n.\tO\n\nSome\tO\nof\tO\nthe\tO\nfactors\tO\nrelated\tO\nto\tO\nthe\tO\nclinical\tO\npresentation\tO\nand\tO\npathogenesis\tO\nof\tO\nthe\tO\nneuropathies\tB-Disease\nare\tO\nbriefly\tO\ndiscussed\tO\n.\tO\n\nReduction\tO\nin\tO\ncaffeine\tB-Chemical\ntoxicity\tB-Disease\nby\tO\nacetaminophen\tB-Chemical\n.\tO\n\nA\tO\npatient\tO\nwho\tO\nallegedly\tO\nconsumed\tO\n100\tO\ntablets\tO\nof\tO\nan\tO\nover\tO\n-\tO\nthe\tO\n-\tO\ncounter\tO\nanalgesic\tO\ncontaining\tO\nsodium\tB-Chemical\nacetylsalicylate\tI-Chemical\n,\tO\ncaffeine\tB-Chemical\n,\tO\nand\tO\nacetaminophen\tB-Chemical\ndisplayed\tO\nno\tO\nsignificant\tO\nCNS\tO\nstimulation\tO\ndespite\tO\nthe\tO\npresence\tO\nof\tO\n175\tO\nmicrograms\tO\nof\tO\ncaffeine\tB-Chemical\nper\tO\nmL\tO\nof\tO\nserum\tO\n.\tO\n\nBecause\tO\nsalicylates\tO\nhave\tO\nbeen\tO\nreported\tO\nto\tO\naugment\tO\nthe\tO\nstimulatory\tO\neffects\tO\nof\tO\ncaffeine\tB-Chemical\non\tO\nthe\tO\nCNS\tO\n,\tO\nattention\tO\nwas\tO\nfocused\tO\non\tO\nthe\tO\npossibility\tO\nthat\tO\nthe\tO\npresence\tO\nof\tO\nacetaminophen\tB-Chemical\n(\tO\n52\tO\nmicrograms\tO\n/\tO\nmL\tO\n)\tO\nreduced\tO\nthe\tO\nCNS\tO\ntoxicity\tB-Disease\nof\tO\ncaffeine\tB-Chemical\n.\tO\n\nStudies\tO\nin\tO\nDBA\tO\n/\tO\n2J\tO\nmice\tO\nshowed\tO\nthat\tO\n:\tO\n1\tO\n)\tO\npretreatment\tO\nwith\tO\nacetaminophen\tB-Chemical\n(\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nincreased\tO\nthe\tO\ninterval\tO\nbetween\tO\nthe\tO\nadministration\tO\nof\tO\ncaffeine\tB-Chemical\n(\tO\n300\tO\nto\tO\n450\tO\nmg\tO\n/\tO\nkg\tO\nIP\tO\n)\tO\nand\tO\nthe\tO\nonset\tO\nof\tO\nfatal\tO\nconvulsions\tB-Disease\nby\tO\na\tO\nfactor\tO\nof\tO\nabout\tO\ntwo\tO\n;\tO\nand\tO\n2\tO\n)\tO\npretreatment\tO\nwith\tO\nacetaminophen\tB-Chemical\n(\tO\n75\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nreduced\tO\nthe\tO\nincidence\tO\nof\tO\naudiogenic\tO\nseizures\tB-Disease\nproduced\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\ncaffeine\tB-Chemical\n(\tO\n12\tO\n.\tO\n5\tO\nto\tO\n75\tO\nmg\tO\n/\tO\nkg\tO\nIP\tO\n)\tO\n.\tO\n\nThe\tO\nfrequency\tO\nof\tO\nsound\tO\n-\tO\ninduced\tO\nseizures\tB-Disease\nafter\tO\n12\tO\n.\tO\n5\tO\nor\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\ncaffeine\tB-Chemical\nwas\tO\nreduced\tO\nfrom\tO\n50\tO\nto\tO\n5\tO\n%\tO\nby\tO\nacetaminophen\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\nabsence\tO\nof\tO\ncaffeine\tB-Chemical\n,\tO\nacetaminophen\tB-Chemical\n(\tO\nup\tO\nto\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\ndid\tO\nnot\tO\nmodify\tO\nthe\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\nmaximal\tO\nelectroshock\tO\nand\tO\ndid\tO\nnot\tO\nalter\tO\nthe\tO\nconvulsant\tO\ndose\tO\nof\tO\npentylenetetrezol\tB-Chemical\nin\tO\nmice\tO\n(\tO\ntests\tO\nperformed\tO\nby\tO\nthe\tO\nAnticonvulsant\tO\nScreening\tO\nProject\tO\nof\tO\nNINCDS\tO\n)\tO\n.\tO\n\nAcetaminophen\tB-Chemical\n(\tO\nup\tO\nto\tO\n150\tO\nmicrograms\tO\n/\tO\nmL\tO\n)\tO\ndid\tO\nnot\tO\nretard\tO\nthe\tO\nincorporation\tO\nof\tO\nradioactive\tO\nadenosine\tB-Chemical\ninto\tO\nATP\tB-Chemical\nin\tO\nslices\tO\nof\tO\nrat\tO\ncerebral\tO\ncortex\tO\n.\tO\n\nThus\tO\nthe\tO\nmechanism\tO\nby\tO\nwhich\tO\nacetaminophen\tB-Chemical\nantagonizes\tO\nthe\tO\nactions\tO\nof\tO\ncaffeine\tB-Chemical\nin\tO\nthe\tO\nCNS\tO\nremains\tO\nunknown\tO\n.\tO\n\nA\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\nof\tO\nthe\tO\nefficacy\tO\nand\tO\nsafety\tO\nof\tO\ndothiepin\tB-Chemical\nhydrochloride\tI-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nmajor\tO\ndepressive\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nIn\tO\na\tO\n6\tO\n-\tO\nweek\tO\ndouble\tO\n-\tO\nblind\tO\nparallel\tO\ntreatment\tO\nstudy\tO\n,\tO\ndothiepin\tB-Chemical\nand\tO\namitriptyline\tB-Chemical\nwere\tO\ncompared\tO\nto\tO\nplacebo\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\n33\tO\ndepressed\tB-Disease\noutpatients\tO\n.\tO\n\nDothiepin\tB-Chemical\nand\tO\namitriptyline\tB-Chemical\nwere\tO\nequally\tO\neffective\tO\nin\tO\nalleviating\tO\nthe\tO\nsymptoms\tO\nof\tO\ndepressive\tB-Disease\nillness\tI-Disease\n,\tO\nand\tO\nboth\tO\nwere\tO\nsignificantly\tO\nsuperior\tO\nto\tO\nplacebo\tO\n.\tO\n\nThe\tO\noverall\tO\nincidence\tO\nof\tO\nside\tO\neffects\tO\nand\tO\nthe\tO\nfrequency\tO\nand\tO\nseverity\tO\nof\tO\nblurred\tB-Disease\nvision\tI-Disease\n,\tO\ndry\tB-Disease\nmouth\tI-Disease\n,\tO\nand\tO\ndrowsiness\tO\nwere\tO\nsignificantly\tO\nless\tO\nwith\tO\ndothiepin\tB-Chemical\nthan\tO\nwith\tO\namitriptyline\tB-Chemical\n.\tO\n\nDothiepin\tB-Chemical\nalso\tO\nproduced\tO\nfewer\tO\nCNS\tO\nand\tO\ncardiovascular\tO\neffects\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nclinically\tO\nimportant\tO\nchanges\tO\nin\tO\nlaboratory\tO\nparameters\tO\n.\tO\n\nDothiepin\tB-Chemical\nthus\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\nan\tO\neffective\tO\nantidepressant\tB-Chemical\ndrug\tO\nassociated\tO\nwith\tO\nfewer\tO\nside\tO\neffects\tO\nthan\tO\namitriptyline\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\ndepressed\tB-Disease\noutpatients\tO\n.\tO\n\nBehavioral\tO\neffects\tO\nof\tO\ndiazepam\tB-Chemical\nand\tO\npropranolol\tB-Chemical\nin\tO\npatients\tO\nwith\tO\npanic\tB-Disease\ndisorder\tI-Disease\nand\tO\nagoraphobia\tB-Disease\n.\tO\n\nThe\tO\neffects\tO\nof\tO\noral\tO\ndoses\tO\nof\tO\ndiazepam\tB-Chemical\n(\tO\nsingle\tO\ndose\tO\nof\tO\n10\tO\nmg\tO\nand\tO\na\tO\nmedian\tO\ndose\tO\nof\tO\n30\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\n2\tO\nweeks\tO\n)\tO\nand\tO\npropranolol\tB-Chemical\n(\tO\nsingle\tO\ndose\tO\nof\tO\n80\tO\nmg\tO\nand\tO\na\tO\nmedian\tO\ndose\tO\nof\tO\n240\tO\nmg\tO\n/\tO\nday\tO\nfor\tO\n2\tO\nweeks\tO\n)\tO\non\tO\npsychological\tO\nperformance\tO\nof\tO\npatients\tO\nwith\tO\npanic\tB-Disease\ndisorders\tI-Disease\nand\tO\nagoraphobia\tB-Disease\nwere\tO\ninvestigated\tO\nin\tO\na\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nrandomized\tO\nand\tO\ncrossover\tO\ndesign\tO\n.\tO\n\nBoth\tO\ndrugs\tO\nimpaired\tB-Disease\nimmediate\tI-Disease\nfree\tI-Disease\nrecall\tI-Disease\nbut\tO\nthe\tO\ndecrease\tO\nwas\tO\ngreater\tO\nfor\tO\ndiazepam\tB-Chemical\nthan\tO\npropranolol\tB-Chemical\n.\tO\n\nDelayed\tB-Disease\nfree\tI-Disease\nrecall\tI-Disease\nwas\tI-Disease\nalso\tI-Disease\nimpaired\tI-Disease\nbut\tO\nthe\tO\ntwo\tO\ndrugs\tO\ndid\tO\nnot\tO\ndiffer\tO\n.\tO\n\nPatients\tO\ntapped\tO\nfaster\tO\nafter\tO\npropranolol\tB-Chemical\nthan\tO\ndiazepam\tB-Chemical\nand\tO\nthey\tO\nwere\tO\nmore\tO\nsedated\tO\nafter\tO\ndiazepam\tB-Chemical\nthan\tO\npropranolol\tB-Chemical\n.\tO\n\nAfter\tO\n2\tO\nweeks\tO\nof\tO\ntreatment\tO\n,\tO\npatients\tO\ntested\tO\n5\tO\n-\tO\n8\tO\nh\tO\nafter\tO\nthe\tO\nlast\tO\ndose\tO\nof\tO\nmedication\tO\ndid\tO\nnot\tO\nshow\tO\nany\tO\ndecrement\tO\nof\tO\nperformance\tO\n.\tO\n\nThese\tO\nresults\tO\nare\tO\nsimilar\tO\nto\tO\nthose\tO\npreviously\tO\nfound\tO\nin\tO\nhealthy\tO\nsubjects\tO\n.\tO\n\nAccumulation\tO\nof\tO\ndrugs\tO\nwas\tO\nnot\tO\nreflected\tO\nin\tO\nprolonged\tO\nbehavioral\tB-Disease\nimpairment\tI-Disease\n.\tO\n\nComparison\tO\nof\tO\ni\tO\n.\tO\nv\tO\n.\tO\nglycopyrrolate\tB-Chemical\nand\tO\natropine\tB-Chemical\nin\tO\nthe\tO\nprevention\tO\nof\tO\nbradycardia\tB-Disease\nand\tO\narrhythmias\tB-Disease\nfollowing\tO\nrepeated\tO\ndoses\tO\nof\tO\nsuxamethonium\tB-Chemical\nin\tO\nchildren\tO\n.\tO\n\nThe\tO\neffectiveness\tO\nof\tO\nadministration\tO\nof\tO\nglycopyrrolate\tB-Chemical\n5\tO\nand\tO\n10\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nand\tO\natropine\tB-Chemical\n10\tO\nand\tO\n20\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\nv\tO\n.\tO\nimmediately\tO\nbefore\tO\nthe\tO\ninduction\tO\nof\tO\nanaesthesia\tO\n,\tO\nto\tO\nprevent\tO\narrhythmia\tB-Disease\nand\tO\nbradycardia\tB-Disease\nfollowing\tO\nrepeated\tO\ndoses\tO\nof\tO\nsuxamethonium\tB-Chemical\nin\tO\nchildren\tO\n,\tO\nwas\tO\nstudied\tO\n.\tO\n\nA\tO\ncontrol\tO\ngroup\tO\nwas\tO\nincluded\tO\nfor\tO\ncomparison\tO\nwith\tO\nthe\tO\nlower\tO\ndose\tO\nrange\tO\nof\tO\nglycopyrrolate\tB-Chemical\nand\tO\natropine\tB-Chemical\n.\tO\n\nA\tO\nfrequency\tO\nof\tO\nbradycardia\tB-Disease\nof\tO\n50\tO\n%\tO\nwas\tO\nnoted\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n,\tO\nbut\tO\nthis\tO\nwas\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\nfrom\tO\nthe\tO\nfrequency\tO\nwith\tO\nthe\tO\nactive\tO\ndrugs\tO\n.\tO\n\nBradycardia\tB-Disease\n(\tO\ndefined\tO\nas\tO\na\tO\ndecrease\tO\nin\tO\nheart\tO\nrate\tO\nto\tO\nless\tO\nthan\tO\n50\tO\nbeat\tO\nmin\tO\n-\tO\n1\tO\n)\tO\nwas\tO\nprevented\tO\nwhen\tO\nthe\tO\nlarger\tO\ndose\tO\nof\tO\neither\tO\nactive\tO\ndrug\tO\nwas\tO\nused\tO\n.\tO\n\nIt\tO\nis\tO\nrecommended\tO\nthat\tO\neither\tO\nglycopyrrolate\tB-Chemical\n10\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nor\tO\natropine\tB-Chemical\n20\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\nv\tO\n.\tO\nshould\tO\nimmediately\tO\nprecede\tO\ninduction\tO\nof\tO\nanaesthesia\tO\n,\tO\nin\tO\nchildren\tO\n,\tO\nif\tO\nthe\tO\nrepeated\tO\nadministration\tO\nof\tO\nsuxamethonium\tB-Chemical\nis\tO\nanticipated\tO\n.\tO\n\nVeno\tB-Disease\n-\tI-Disease\nocclusive\tI-Disease\nliver\tI-Disease\ndisease\tI-Disease\nafter\tO\ndacarbazine\tB-Chemical\ntherapy\tO\n(\tO\nDTIC\tB-Chemical\n)\tO\nfor\tO\nmelanoma\tB-Disease\n.\tO\n\nA\tO\ncase\tO\nof\tO\nveno\tB-Disease\n-\tI-Disease\nocclusive\tI-Disease\ndisease\tI-Disease\nof\tI-Disease\nthe\tI-Disease\nliver\tI-Disease\nwith\tO\nfatal\tO\noutcome\tO\nafter\tO\ndacarbazine\tB-Chemical\n(\tO\nDTIC\tB-Chemical\n)\tO\ntherapy\tO\nfor\tO\nmelanoma\tB-Disease\nis\tO\nreported\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nfulminant\tO\nclinical\tO\ncourse\tO\nfrom\tO\nstart\tO\nof\tO\nsymptoms\tO\nuntil\tO\ndeath\tB-Disease\n.\tO\n\nAt\tO\nautopsy\tO\nthe\tO\nliver\tO\nwas\tO\nenlarged\tO\nand\tO\nfirm\tO\nwith\tO\nsigns\tO\nof\tO\nvenous\tB-Disease\ncongestion\tI-Disease\n.\tO\n\nSmall\tO\n-\tO\nand\tO\nmedium\tO\n-\tO\nsized\tO\nhepatic\tO\nveins\tO\nwere\tO\nblocked\tO\nby\tO\nthrombosis\tB-Disease\n.\tO\n\nEosinophilic\tO\ninfiltrations\tO\nwere\tO\nfound\tO\naround\tO\nthe\tO\nvessels\tO\n.\tO\n\nPublished\tO\ncases\tO\nfrom\tO\nthe\tO\nliterature\tO\nare\tO\nreviewed\tO\nand\tO\npertinent\tO\nfeatures\tO\ndiscussed\tO\n.\tO\n\nMaternal\tO\nlithium\tB-Chemical\nand\tO\nneonatal\tO\nEbstein\tB-Disease\n'\tI-Disease\ns\tI-Disease\nanomaly\tI-Disease\n:\tO\nevaluation\tO\nwith\tO\ncross\tO\n-\tO\nsectional\tO\nechocardiography\tO\n.\tO\n\nCross\tO\n-\tO\nsectional\tO\nechocardiography\tO\nwas\tO\nused\tO\nto\tO\nevaluate\tO\ntwo\tO\nneonates\tO\nwhose\tO\nmothers\tO\ningested\tO\nlithium\tB-Chemical\nduring\tO\npregnancy\tO\n.\tO\n\nIn\tO\none\tO\ninfant\tO\n,\tO\nEbstein\tB-Disease\n'\tI-Disease\ns\tI-Disease\nanomaly\tI-Disease\nof\tO\nthe\tO\ntricuspid\tO\nvalve\tO\nwas\tO\nidentified\tO\n.\tO\n\nIn\tO\nthe\tO\nother\tO\ninfant\tO\ncross\tO\n-\tO\nsectional\tO\nechocardiography\tO\nprovided\tO\nreassurance\tO\nthat\tO\nthe\tO\ninfant\tO\ndid\tO\nnot\tO\nhave\tO\nEbstein\tB-Disease\n'\tI-Disease\ns\tI-Disease\nanomaly\tI-Disease\n.\tO\n\nCross\tO\n-\tO\nsectional\tO\nechocardiographic\tO\nscreening\tO\nof\tO\nnewborns\tO\nexposed\tO\nto\tO\nlithium\tB-Chemical\nduring\tO\ngestation\tO\ncan\tO\nprovide\tO\nhighly\tO\naccurate\tO\n,\tO\nnoninvasive\tO\nassessment\tO\nof\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\nmalformations\tI-Disease\n.\tO\n\nEffects\tO\nof\tO\ntraining\tO\non\tO\nthe\tO\nextent\tO\nof\tO\nexperimental\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\naging\tO\nrats\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nexercise\tO\non\tO\nthe\tO\nseverity\tO\nof\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwere\tO\nstudied\tO\nin\tO\nfemale\tO\nalbino\tO\nrats\tO\nof\tO\n20\tO\n,\tO\n40\tO\n,\tO\n60\tO\nand\tO\n80\tO\nweeks\tO\nof\tO\nage\tO\n.\tO\n\nThe\tO\nrats\tO\nwere\tO\ntrained\tO\nto\tO\nswim\tO\nfor\tO\na\tO\nspecific\tO\nduration\tO\nand\tO\nfor\tO\na\tO\nparticular\tO\nperiod\tO\n.\tO\n\nThe\tO\noccurrence\tO\nof\tO\ninfarcts\tB-Disease\nwere\tO\nconfirmed\tO\nby\tO\nhistological\tO\nmethods\tO\n.\tO\n\nElevations\tO\nin\tO\nthe\tO\nserum\tO\nGOT\tO\nand\tO\nGPT\tO\nwere\tO\nmaximum\tO\nin\tO\nthe\tO\nsedentary\tO\n-\tO\nisoproterenols\tB-Chemical\nand\tO\nminimum\tO\nin\tO\nthe\tO\nexercise\tO\n-\tO\ncontrols\tO\n.\tO\n\nThese\tO\nchanges\tO\nin\tO\nthe\tO\nserum\tO\ntransaminases\tO\nwere\tO\nassociated\tO\nwith\tO\ncorresponding\tO\ndepletions\tO\nin\tO\nthe\tO\ncardiac\tO\nGOT\tO\nand\tO\nGPT\tO\n.\tO\n\nHowever\tO\n,\tO\nage\tO\nwas\tO\nseen\tO\nto\tO\ninterfere\tO\nwith\tO\nthe\tO\nresponses\tO\nexhibited\tO\nby\tO\nthe\tO\nyoung\tO\nand\tO\nold\tO\nrats\tO\n.\tO\n\nStudies\tO\ndealing\tO\nwith\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nare\tO\nmore\tO\ninformative\tO\nwhen\tO\ndealt\tO\nwith\tO\nage\tO\n.\tO\n\nEffect\tO\nof\tO\npolyethylene\tB-Chemical\nglycol\tI-Chemical\n400\tI-Chemical\non\tO\nadriamycin\tB-Chemical\ntoxicity\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\na\tO\nwidely\tO\nused\tO\norganic\tO\nsolvent\tO\n,\tO\npolyethylene\tB-Chemical\nglycol\tI-Chemical\n400\tI-Chemical\n(\tO\nPEG\tB-Chemical\n400\tI-Chemical\n)\tO\n,\tO\non\tO\nthe\tO\ntoxic\tO\naction\tO\nof\tO\nan\tO\nacute\tO\nor\tO\nchronic\tO\ntreatment\tO\nwith\tO\nadriamycin\tB-Chemical\n(\tO\nADR\tB-Chemical\n)\tO\nwas\tO\nevaluated\tO\nin\tO\nmice\tO\n.\tO\n\nPEG\tB-Chemical\n400\tI-Chemical\nimpressively\tO\ndecreased\tO\nboth\tO\nacute\tO\nhigh\tO\n-\tO\ndose\tO\nand\tO\nchronic\tO\nlow\tO\n-\tO\ndose\tO\n-\tO\nADR\tB-Chemical\n-\tO\nassociated\tO\nlethality\tO\n.\tO\n\nLight\tO\nmicroscopic\tO\nanalysis\tO\nshowed\tO\na\tO\nsignificant\tO\nprotection\tO\nagainst\tO\nADR\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\nmorphological\tI-Disease\nalterations\tI-Disease\n.\tO\n\nSuch\tO\ntreatment\tO\ndid\tO\nnot\tO\ndiminish\tO\nthe\tO\nADR\tB-Chemical\nantitumor\tO\nactivity\tO\nin\tO\nL1210\tB-Disease\nleukemia\tI-Disease\nand\tO\nin\tO\nEhrlich\tB-Disease\nascites\tI-Disease\ntumor\tI-Disease\n.\tO\n\nSublingual\tO\nabsorption\tO\nof\tO\nthe\tO\nquaternary\tB-Chemical\nammonium\tI-Chemical\nantiarrhythmic\tO\nagent\tO\n,\tO\nUM\tB-Chemical\n-\tI-Chemical\n272\tI-Chemical\n.\tO\n\nUM\tB-Chemical\n-\tI-Chemical\n272\tI-Chemical\n(\tO\nN\tB-Chemical\n,\tI-Chemical\nN\tI-Chemical\n-\tI-Chemical\ndimethylpropranolol\tI-Chemical\n)\tO\n,\tO\na\tO\nquaternary\tO\nantiarrhythmic\tO\nagent\tO\n,\tO\nwas\tO\nadministered\tO\nsublingually\tO\nto\tO\ndogs\tO\nwith\tO\nouabain\tB-Chemical\n-\tO\ninduced\tO\nventricular\tB-Disease\ntachycardias\tI-Disease\n.\tO\n\nBoth\tO\nanti\tO\n-\tO\narrhythmic\tO\nefficacy\tO\nand\tO\nbioavailability\tO\nwere\tO\ncompared\tO\nto\tO\noral\tO\ndrug\tO\n.\tO\n\nSublingual\tO\nUM\tB-Chemical\n-\tI-Chemical\n272\tI-Chemical\nconverted\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nto\tO\nsinus\tO\nrhythm\tO\nin\tO\nall\tO\n5\tO\ndogs\tO\n.\tO\n\nThe\tO\narea\tO\nunder\tO\nthe\tO\nplasma\tO\nconcentration\tO\ntime\tO\ncurve\tO\nat\tO\n90\tO\nmin\tO\nwas\tO\n4\tO\n-\tO\n12\tO\ntimes\tO\ngreater\tO\nthan\tO\nfor\tO\noral\tO\ndrug\tO\n,\tO\nsuggesting\tO\nthe\tO\nexistence\tO\nof\tO\nan\tO\nabsorption\tO\n-\tO\nlimiting\tO\nprocess\tO\nin\tO\nthe\tO\nintestine\tO\n,\tO\nand\tO\nproviding\tO\nan\tO\nalternate\tO\nform\tO\nof\tO\nadministration\tO\nfor\tO\nquaternary\tO\ndrugs\tO\n.\tO\n\nEarly\tO\nadjuvant\tO\nadriamycin\tB-Chemical\nin\tO\nsuperficial\tO\nbladder\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nA\tO\nmulticenter\tO\nstudy\tO\nwas\tO\nperformed\tO\nin\tO\n110\tO\npatients\tO\nwith\tO\nsuperficial\tO\ntransitional\tO\ncell\tO\ncarcinoma\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nbladder\tI-Disease\n.\tO\n\nAdriamycin\tB-Chemical\n(\tO\n50\tO\nmg\tO\n/\tO\n50\tO\nml\tO\n)\tO\nwas\tO\nadministered\tO\nintravesically\tO\nwithin\tO\n24\tO\nh\tO\nafter\tO\ntransurethral\tO\nresection\tO\nof\tO\nTA\tO\n-\tO\nT1\tO\n(\tO\nO\tO\n-\tO\nA\tO\n)\tO\nbladder\tB-Disease\ntumors\tI-Disease\n.\tO\n\nInstillation\tO\nwas\tO\nrepeated\tO\ntwice\tO\nduring\tO\nthe\tO\nfirst\tO\nweek\tO\n,\tO\nthen\tO\nweekly\tO\nduring\tO\nthe\tO\nfirst\tO\nmonth\tO\nand\tO\nafterwards\tO\nmonthly\tO\nfor\tO\n1\tO\nyear\tO\n.\tO\n\nThe\tO\ntolerance\tO\nwas\tO\nevaluated\tO\nin\tO\nthese\tO\n110\tO\npatients\tO\n,\tO\nand\tO\n29\tO\npatients\tO\npresented\tO\nwith\tO\nlocal\tO\nside\tO\n-\tO\neffects\tO\n.\tO\n\nIn\tO\n24\tO\nof\tO\nthese\tO\npatients\tO\nchemical\tO\ncystitis\tB-Disease\nwas\tO\nsevere\tO\nenough\tO\nfor\tO\nthem\tO\nto\tO\ndrop\tO\nout\tO\nof\tO\nthe\tO\nstudy\tO\n.\tO\n\nNo\tO\nsystemic\tO\nside\tO\n-\tO\neffects\tO\nwere\tO\nobserved\tO\n.\tO\n\nRecurrence\tO\nwas\tO\nstudied\tO\nin\tO\n82\tO\nevaluable\tO\npatients\tO\nafter\tO\n1\tO\nyear\tO\nof\tO\nfollow\tO\n-\tO\nup\tO\nand\tO\nin\tO\n72\tO\npatients\tO\nfollowed\tO\nfor\tO\n2\tO\n-\tO\n3\tO\nyears\tO\n(\tO\nmean\tO\n32\tO\nmonths\tO\n)\tO\n.\tO\n\nOf\tO\nthe\tO\n82\tO\npatients\tO\nstudied\tO\nafter\tO\n1\tO\nyear\tO\n,\tO\n23\tO\nhad\tO\nprimary\tO\nand\tO\n59\tO\nrecurrent\tO\ndisease\tO\n.\tO\n\nOf\tO\nthe\tO\n82\tO\nevaluable\tO\npatients\tO\n,\tO\n50\tO\ndid\tO\nnot\tO\nshow\tO\nany\tO\nrecurrence\tO\nafter\tO\n1\tO\nyear\tO\n(\tO\n61\tO\n%\tO\n)\tO\n,\tO\nwhile\tO\n32\tO\npresented\tO\nwith\tO\none\tO\nor\tO\nmore\tO\nrecurrences\tO\n(\tO\n39\tO\n%\tO\n)\tO\n.\tO\n\nOf\tO\nthese\tO\nrecurrences\tO\n,\tO\n27\tO\nwere\tO\nT1\tO\ntumors\tB-Disease\nwhile\tO\nfive\tO\nprogressed\tO\nto\tO\nmore\tO\nhighly\tO\ninvasive\tO\nlesions\tO\n.\tO\n\nIn\tO\npatients\tO\nthat\tO\nwere\tO\nfree\tO\nof\tO\nrecurrence\tO\nduring\tO\nthe\tO\nfirst\tO\nyear\tO\n,\tO\n80\tO\n%\tO\nremained\tO\ntumor\tB-Disease\n-\tO\nfree\tO\nduring\tO\nthe\tO\n2\tO\n-\tO\nto\tO\n3\tO\n-\tO\nyear\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n.\tO\n\nOf\tO\nthe\tO\npatients\tO\ndeveloping\tO\none\tO\nor\tO\nmore\tO\nrecurrences\tO\nduring\tO\nthe\tO\nfirst\tO\nyear\tO\n,\tO\nonly\tO\n50\tO\n%\tO\npresented\tO\nwith\tO\nfurther\tO\nrecurrence\tO\nonce\tO\nthe\tO\ninstillations\tO\nwere\tO\nstopped\tO\n.\tO\n\nThe\tO\nbeneficial\tO\neffect\tO\nof\tO\nAdriamycin\tB-Chemical\nappears\tO\nobvious\tO\nand\tO\nmight\tO\nbe\tO\nrelated\tO\nto\tO\nthe\tO\ndrug\tO\nitself\tO\n,\tO\nthe\tO\nearly\tO\nand\tO\nrepeated\tO\ninstillations\tO\nafter\tO\nTUR\tO\n,\tO\nor\tO\nboth\tO\n.\tO\n\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n-\tO\ninduced\tO\nangiopathy\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nhigh\tO\ndose\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\ntreatment\tO\non\tO\naortic\tO\npermeability\tO\nto\tO\nalbumin\tO\nand\tO\non\tO\nthe\tO\nultrastructure\tO\nof\tO\nthe\tO\nvessel\tO\n.\tO\n\nMale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\nwere\tO\ntreated\tO\nwith\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n(\tO\nD\tB-Chemical\n-\tI-Chemical\npen\tI-Chemical\n)\tO\n500\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nfor\tO\n10\tO\nor\tO\n42\tO\ndays\tO\n.\tO\n\nPair\tO\nfed\tO\nrats\tO\nserved\tO\nas\tO\ncontrols\tO\n.\tO\n\nChanges\tO\nin\tO\naortic\tO\nmorphology\tO\nwere\tO\nexamined\tO\nby\tO\nlight\tO\n-\tO\nand\tO\ntransmission\tO\n-\tO\nelectron\tO\nmicroscopy\tO\n(\tO\nTEM\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthe\tO\nendothelial\tO\npermeability\tO\nand\tO\nthe\tO\npenetration\tO\nthrough\tO\nthe\tO\naortic\tO\nwall\tO\nof\tO\nalbumin\tO\nwere\tO\nstudied\tO\n10\tO\nminutes\tO\n,\tO\n24\tO\nand\tO\n48\tO\nhours\tO\nafter\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninjection\tO\nof\tO\nhuman\tO\nserum\tO\n131I\tO\n-\tO\nalbumin\tO\n(\tO\n131I\tO\n-\tO\nHSA\tO\n)\tO\n.\tO\n\nTEM\tO\nrevealed\tO\nextensive\tO\nelastolysis\tO\nin\tO\nthe\tO\narterial\tO\nwall\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npen\tI-Chemical\n-\tO\ntreated\tO\nrats\tO\n,\tO\nconsistent\tO\nwith\tO\nan\tO\ninhibitory\tO\neffect\tO\non\tO\ncrosslink\tO\nformation\tO\n.\tO\n\nIn\tO\nexperimental\tO\nanimals\tO\nexcess\tO\ndeposition\tO\nof\tO\ncollagen\tO\nand\tO\nglycoaminoglycans\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\nsubendothelial\tO\nand\tO\nmedial\tO\nlayer\tO\nof\tO\nthe\tO\naortic\tO\nwall\tO\n,\tO\ntogether\tO\nwith\tO\nprominent\tO\nbasal\tO\nmembrane\tO\nsubstance\tO\naround\tO\naortic\tO\nsmooth\tO\nmuscle\tO\ncells\tO\n.\tO\n\nThe\tO\naorta\tO\n/\tO\nserum\tO\n-\tO\nratio\tO\nand\tO\nthe\tO\nradioactive\tO\nbuild\tO\n-\tO\nup\tO\n24\tO\nand\tO\n48\tO\nhours\tO\nafter\tO\ninjection\tO\nof\tO\n131I\tO\n-\tO\nHSA\tO\nwas\tO\nreduced\tO\nin\tO\nanimals\tO\ntreated\tO\nwith\tO\nD\tB-Chemical\n-\tI-Chemical\npen\tI-Chemical\nfor\tO\n42\tO\ndays\tO\n,\tO\nindicating\tO\nan\tO\nimpeded\tO\ntransmural\tO\ntransport\tO\nof\tO\ntracer\tO\nwhich\tO\nmay\tO\nbe\tO\ncaused\tO\nby\tO\na\tO\nsteric\tO\nexclusion\tO\neffect\tO\nof\tO\nabundant\tO\nhyaluronate\tB-Chemical\n.\tO\n\nThe\tO\nendothelial\tO\nultrastructure\tO\nwas\tO\nunaffected\tO\nby\tO\nD\tB-Chemical\n-\tI-Chemical\npen\tI-Chemical\n,\tO\nand\tO\nno\tO\ndifferences\tO\nin\tO\naortic\tO\n131I\tO\n-\tO\nHSA\tO\nradioactivity\tO\nor\tO\naorta\tO\n/\tO\nserum\tO\n-\tO\nratio\tO\nwere\tO\nrecorded\tO\nbetween\tO\nexperimental\tO\nand\tO\ncontrol\tO\ngroups\tO\n10\tO\nminutes\tO\nafter\tO\ntracer\tO\ninjection\tO\n,\tO\nindicating\tO\nthat\tO\nthe\tO\npermeability\tO\nof\tO\nthe\tO\nendothelial\tO\nbarrier\tO\nto\tO\nalbumin\tO\nremained\tO\nunaffected\tO\nby\tO\nD\tB-Chemical\n-\tI-Chemical\npen\tI-Chemical\ntreatment\tO\n.\tO\n\nThese\tO\nobservations\tO\nsupport\tO\nthe\tO\nhypothesis\tO\nthat\tO\ntreatment\tO\nwith\tO\nhigh\tO\ndoses\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npen\tI-Chemical\nmay\tO\ninduce\tO\na\tO\nfibroproliferative\tO\nresponse\tO\nin\tO\nrat\tO\naorta\tO\n,\tO\npossibly\tO\nby\tO\nan\tO\ninhibitory\tO\neffect\tO\non\tO\nthe\tO\ncross\tO\n-\tO\nlinking\tO\nof\tO\ncollagen\tO\nand\tO\nelastin\tO\n.\tO\n\nEffect\tO\nof\tO\naspirin\tB-Chemical\non\tO\nN\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\nnitro\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nfuryl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nthiazolyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nformamide\tI-Chemical\n-\tO\ninduced\tO\nepithelial\tO\nproliferation\tO\nin\tO\nthe\tO\nurinary\tO\nbladder\tO\nand\tO\nforestomach\tO\nof\tO\nthe\tO\nrat\tO\n.\tO\n\nThe\tO\nco\tO\n-\tO\nadministration\tO\nof\tO\naspirin\tB-Chemical\nwith\tO\nN\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\nnitro\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nfuryl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nthiazolyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nformamide\tI-Chemical\n(\tO\nFANFT\tB-Chemical\n)\tO\nto\tO\nrats\tO\nresulted\tO\nin\tO\na\tO\nreduced\tO\nincidence\tO\nof\tO\nFANFT\tB-Chemical\n-\tO\ninduced\tO\nbladder\tB-Disease\ncarcinomas\tI-Disease\nbut\tO\na\tO\nconcomitant\tO\ninduction\tO\nof\tO\nforestomach\tB-Disease\ntumors\tI-Disease\n.\tO\n\nAn\tO\nautoradiographic\tO\nstudy\tO\nwas\tO\nperformed\tO\non\tO\nmale\tO\nF\tO\n-\tO\n344\tO\nrats\tO\nfed\tO\ndiet\tO\ncontaining\tO\nFANFT\tB-Chemical\nat\tO\na\tO\nlevel\tO\nof\tO\n0\tO\n.\tO\n2\tO\n%\tO\nand\tO\n/\tO\nor\tO\naspirin\tB-Chemical\nat\tO\na\tO\nlevel\tO\nof\tO\n0\tO\n.\tO\n5\tO\n%\tO\nto\tO\nevaluate\tO\nthe\tO\neffect\tO\nof\tO\naspirin\tB-Chemical\non\tO\nthe\tO\nincreased\tO\ncell\tO\nproliferation\tO\ninduced\tO\nby\tO\nFANFT\tB-Chemical\nin\tO\nthe\tO\nforestomach\tO\nand\tO\nbladder\tO\n.\tO\n\nFANFT\tB-Chemical\n-\tO\ninduced\tO\ncell\tO\nproliferation\tO\nin\tO\nthe\tO\nbladder\tO\nwas\tO\nsignificantly\tO\nsuppressed\tO\nby\tO\naspirin\tB-Chemical\nco\tO\n-\tO\nadministration\tO\nafter\tO\n4\tO\nweeks\tO\nbut\tO\nnot\tO\nafter\tO\n12\tO\nweeks\tO\n.\tO\n\nIn\tO\nthe\tO\nforestomach\tO\n,\tO\nand\tO\nalso\tO\nin\tO\nthe\tO\nliver\tO\n,\tO\naspirin\tB-Chemical\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nFANFT\tB-Chemical\n-\tO\ninduced\tO\nincrease\tO\nin\tO\nlabeling\tO\nindex\tO\n.\tO\n\nThe\tO\npresent\tO\nresults\tO\nare\tO\nconsistent\tO\nwith\tO\nthe\tO\ncarcinogenicity\tO\nexperiment\tO\nsuggesting\tO\nthat\tO\ndifferent\tO\nmechanisms\tO\nare\tO\ninvolved\tO\nin\tO\nFANFT\tB-Chemical\ncarcinogenesis\tB-Disease\nin\tO\nthe\tO\nbladder\tO\nand\tO\nforestomach\tO\n,\tO\nand\tO\nthat\tO\naspirin\tB-Chemical\n'\tO\ns\tO\neffect\tO\non\tO\nFANFT\tB-Chemical\nin\tO\nthe\tO\nforestomach\tO\nis\tO\nnot\tO\ndue\tO\nto\tO\nan\tO\nirritant\tO\neffect\tO\nassociated\tO\nwith\tO\nincreased\tO\ncell\tO\nproliferation\tO\n.\tO\n\nAlso\tO\n,\tO\nthere\tO\nappears\tO\nto\tO\nbe\tO\nan\tO\nadaptation\tO\nby\tO\nthe\tO\nrats\tO\nto\tO\nthe\tO\nchronic\tO\ningestion\tO\nof\tO\naspirin\tB-Chemical\n.\tO\n\nA\tO\ncase\tO\nof\tO\ntardive\tB-Disease\ndyskinesia\tI-Disease\ncaused\tO\nby\tO\nmetoclopramide\tB-Chemical\n.\tO\n\nAbnormal\tB-Disease\ninvoluntary\tI-Disease\nmovements\tI-Disease\nappeared\tO\nin\tO\nthe\tO\nmouth\tO\n,\tO\ntongue\tO\n,\tO\nneck\tO\nand\tO\nabdomen\tO\nof\tO\na\tO\n64\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\npatient\tO\nafter\tO\nhe\tO\ntook\tO\nmetoclopramide\tB-Chemical\nfor\tO\ngastrointestinal\tB-Disease\ndisorder\tI-Disease\nin\tO\na\tO\nregimen\tO\nof\tO\n30\tO\nmg\tO\nper\tO\nday\tO\nfor\tO\na\tO\ntotal\tO\nof\tO\nabout\tO\n260\tO\ndays\tO\n.\tO\n\nThe\tO\nsymptoms\tO\nexacerbated\tO\nto\tO\na\tO\nmaximum\tO\nin\tO\na\tO\nmonth\tO\n.\tO\n\nWhen\tO\nthe\tO\nmetoclopramide\tB-Chemical\nadministration\tO\nwas\tO\ndiscontinued\tO\n,\tO\nthe\tO\nabnormal\tB-Disease\nmovements\tI-Disease\ngradually\tO\nimproved\tO\nto\tO\na\tO\nconsiderable\tO\nextent\tO\n.\tO\n\nAttention\tO\nto\tO\nthe\tO\npossible\tO\ninduction\tO\nof\tO\nspecific\tO\ntardive\tB-Disease\ndyskinesia\tI-Disease\nis\tO\ncalled\tO\nfor\tO\nin\tO\nthe\tO\nuse\tO\nof\tO\nthis\tO\ndrug\tO\n.\tO\n\nIntra\tO\n-\tO\narterial\tO\nBCNU\tB-Chemical\nchemotherapy\tO\nfor\tO\ntreatment\tO\nof\tO\nmalignant\tB-Disease\ngliomas\tI-Disease\nof\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nBecause\tO\nof\tO\nthe\tO\nrapid\tO\nsystemic\tO\nclearance\tO\nof\tO\nBCNU\tB-Chemical\n(\tO\n1\tB-Chemical\n,\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nbis\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nchloroethyl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nnitrosourea\tI-Chemical\n)\tO\n,\tO\nintra\tO\n-\tO\narterial\tO\nadministration\tO\nshould\tO\nprovide\tO\na\tO\nsubstantial\tO\nadvantage\tO\nover\tO\nintravenous\tO\nadministration\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nmalignant\tB-Disease\ngliomas\tI-Disease\n.\tO\n\nThirty\tO\n-\tO\nsix\tO\npatients\tO\nwere\tO\ntreated\tO\nwith\tO\nBCNU\tB-Chemical\nevery\tO\n6\tO\nto\tO\n8\tO\nweeks\tO\n,\tO\neither\tO\nby\tO\ntransfemoral\tO\ncatheterization\tO\nof\tO\nthe\tO\ninternal\tO\ncarotid\tO\nor\tO\nvertebral\tO\nartery\tO\nor\tO\nthrough\tO\na\tO\nfully\tO\nimplantable\tO\nintracarotid\tO\ndrug\tO\ndelivery\tO\nsystem\tO\n,\tO\nbeginning\tO\nwith\tO\na\tO\ndose\tO\nof\tO\n200\tO\nmg\tO\n/\tO\nsq\tO\nm\tO\nbody\tO\nsurface\tO\narea\tO\n.\tO\n\nTwelve\tO\npatients\tO\nwith\tO\nGrade\tO\nIII\tO\nor\tO\nIV\tO\nastrocytomas\tB-Disease\nwere\tO\ntreated\tO\nafter\tO\npartial\tO\nresection\tO\nof\tO\nthe\tO\ntumor\tB-Disease\nwithout\tO\nprior\tO\nradiation\tO\ntherapy\tO\n.\tO\n\nAfter\tO\ntwo\tO\nto\tO\nseven\tO\ncycles\tO\nof\tO\nchemotherapy\tO\n,\tO\nnine\tO\npatients\tO\nshowed\tO\na\tO\ndecrease\tO\nin\tO\ntumor\tB-Disease\nsize\tO\nand\tO\nsurrounding\tO\nedema\tB-Disease\non\tO\ncontrast\tO\n-\tO\nenhanced\tO\ncomputerized\tO\ntomography\tO\nscans\tO\n.\tO\n\nIn\tO\nthe\tO\nnine\tO\nresponders\tO\n,\tO\nmedian\tO\nduration\tO\nof\tO\nchemotherapy\tO\nresponse\tO\nfrom\tO\nthe\tO\ntime\tO\nof\tO\noperation\tO\nwas\tO\n25\tO\nweeks\tO\n(\tO\nrange\tO\n12\tO\nto\tO\nmore\tO\nthan\tO\n91\tO\nweeks\tO\n)\tO\n.\tO\n\nThe\tO\nmedian\tO\nduration\tO\nof\tO\nsurvival\tO\nin\tO\nthe\tO\n12\tO\npatients\tO\nwas\tO\n54\tO\nweeks\tO\n(\tO\nrange\tO\n21\tO\nto\tO\nmore\tO\nthan\tO\n156\tO\nweeks\tO\n)\tO\n,\tO\nwith\tO\nan\tO\n18\tO\n-\tO\nmonth\tO\nsurvival\tO\nrate\tO\nof\tO\n42\tO\n%\tO\n.\tO\n\nTwenty\tO\n-\tO\nfour\tO\npatients\tO\nwith\tO\nrecurrent\tO\nGrade\tO\nI\tO\nto\tO\nIV\tO\nastrocytomas\tB-Disease\n,\tO\nwhose\tO\nresection\tO\nand\tO\nirradiation\tO\ntherapy\tO\nhad\tO\nfailed\tO\n,\tO\nreceived\tO\ntwo\tO\nto\tO\neight\tO\ncourses\tO\nof\tO\nintra\tO\n-\tO\narterial\tO\nBCNU\tB-Chemical\ntherapy\tO\n.\tO\n\nSeventeen\tO\nof\tO\nthese\tO\nhad\tO\na\tO\nresponse\tO\nor\tO\nwere\tO\nstable\tO\nfor\tO\na\tO\nmedian\tO\nof\tO\n20\tO\nweeks\tO\n(\tO\nrange\tO\n6\tO\nto\tO\nmore\tO\nthan\tO\n66\tO\nweeks\tO\n)\tO\n.\tO\n\nThe\tO\ncatheterization\tO\nprocedure\tO\nis\tO\nsafe\tO\n,\tO\nwith\tO\nno\tO\nimmediate\tO\ncomplication\tO\nin\tO\n111\tO\ninfusions\tO\nof\tO\nBCNU\tB-Chemical\n.\tO\n\nA\tO\ndelayed\tO\ncomplication\tO\nin\tO\nnine\tO\npatients\tO\nhas\tO\nbeen\tO\nunilateral\tO\nloss\tB-Disease\nof\tI-Disease\nvision\tI-Disease\nsecondary\tO\nto\tO\na\tO\nretinal\tB-Disease\nvasculitis\tI-Disease\n.\tO\n\nThe\tO\nfrequency\tO\nof\tO\nvisual\tB-Disease\nloss\tI-Disease\ndecreased\tO\nafter\tO\nthe\tO\nconcentration\tO\nof\tO\nthe\tO\nethanol\tB-Chemical\ndiluent\tO\nwas\tO\nlowered\tO\n.\tO\n\nProvocation\tO\nof\tO\npostural\tO\nhypotension\tB-Disease\nby\tO\nnitroglycerin\tB-Chemical\nin\tO\ndiabetic\tB-Disease\nautonomic\tI-Disease\nneuropathy\tI-Disease\n?\tO\n\nThe\tO\neffect\tO\nof\tO\nnitroglycerin\tB-Chemical\non\tO\nheart\tO\nrate\tO\nand\tO\nsystolic\tO\nblood\tO\npressure\tO\nwas\tO\ncompared\tO\nin\tO\n5\tO\nnormal\tO\nsubjects\tO\n,\tO\n12\tO\ndiabetic\tB-Disease\nsubjects\tO\nwithout\tO\nautonomic\tB-Disease\nneuropathy\tI-Disease\n,\tO\nand\tO\n5\tO\ndiabetic\tB-Disease\nsubjects\tO\nwith\tO\nautonomic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nThe\tO\nmagnitude\tO\nand\tO\ntime\tO\ncourse\tO\nof\tO\nthe\tO\nincrease\tO\nin\tO\nheart\tO\nrate\tO\nand\tO\nthe\tO\ndecrease\tO\nin\tO\nsystolic\tO\nblood\tO\npressure\tO\nafter\tO\nnitroglycerin\tB-Chemical\nwere\tO\nsimilar\tO\nin\tO\nthe\tO\nnormal\tO\nand\tO\ndiabetic\tB-Disease\nsubjects\tO\nwithout\tO\nautonomic\tB-Disease\nneuropathy\tI-Disease\n,\tO\nwhereas\tO\na\tO\nlesser\tO\nincrease\tO\nin\tO\nheart\tO\nrate\tO\nand\tO\na\tO\ngreater\tO\ndecrease\tO\nin\tO\nsystolic\tO\nblood\tO\npressure\tO\noccurred\tO\nin\tO\nthe\tO\ndiabetic\tB-Disease\nsubjects\tO\nwith\tO\nautonomic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nIt\tO\nis\tO\ntherefore\tO\nsuggested\tO\nthat\tO\ncaution\tO\nshould\tO\nbe\tO\nexercised\tO\nwhen\tO\nprescribing\tO\nvasodilator\tO\ndrugs\tO\nin\tO\ndiabetic\tB-Disease\npatients\tO\n,\tO\nparticularly\tO\nthose\tO\nwith\tO\nautonomic\tB-Disease\nneuropathy\tI-Disease\n.\tO\n\nBlood\tO\npressure\tO\nresponse\tO\nto\tO\nchronic\tO\nlow\tO\n-\tO\ndose\tO\nintrarenal\tO\nnoradrenaline\tB-Chemical\ninfusion\tO\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nSodium\tB-Chemical\nchloride\tI-Chemical\nsolution\tO\n(\tO\n0\tO\n.\tO\n9\tO\n%\tO\n)\tO\nor\tO\nnoradrenaline\tB-Chemical\nin\tO\ndoses\tO\nof\tO\n4\tO\n,\tO\n12\tO\nand\tO\n36\tO\nmicrograms\tO\nh\tO\n-\tO\n1\tO\nkg\tO\n-\tO\n1\tO\nwas\tO\ninfused\tO\nfor\tO\nfive\tO\nconsecutive\tO\ndays\tO\n,\tO\neither\tO\nintrarenally\tO\n(\tO\nby\tO\na\tO\nnew\tO\ntechnique\tO\n)\tO\nor\tO\nintravenously\tO\ninto\tO\nrats\tO\nwith\tO\none\tO\nkidney\tO\nremoved\tO\n.\tO\n\nIntrarenal\tO\ninfusion\tO\nof\tO\nnoradrenaline\tB-Chemical\ncaused\tO\nhypertension\tB-Disease\nat\tO\ndoses\tO\nwhich\tO\ndid\tO\nnot\tO\ndo\tO\nso\tO\nwhen\tO\ninfused\tO\nintravenously\tO\n.\tO\n\nIntrarenal\tO\ncompared\tO\nwith\tO\nintravenous\tO\ninfusion\tO\nof\tO\nnoradrenaline\tB-Chemical\ncaused\tO\nhigher\tO\nplasma\tO\nnoradrenaline\tB-Chemical\nconcentrations\tO\nand\tO\na\tO\nshift\tO\nof\tO\nthe\tO\nplasma\tO\nnoradrenaline\tB-Chemical\nconcentration\tO\n-\tO\nblood\tO\npressure\tO\neffect\tO\ncurve\tO\ntowards\tO\nlower\tO\nplasma\tO\nnoradrenaline\tB-Chemical\nlevels\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nhypertension\tB-Disease\nafter\tO\nchronic\tO\nintrarenal\tO\nnoradrenaline\tB-Chemical\ninfusion\tO\nis\tO\nproduced\tO\nby\tO\nrelatively\tO\nhigher\tO\nlevels\tO\nof\tO\ncirculating\tO\nnoradrenaline\tB-Chemical\nand\tO\nby\tO\ntriggering\tO\nof\tO\nan\tO\nadditional\tO\nintrarenal\tO\npressor\tO\nmechanism\tO\n.\tO\n\nCharacterization\tO\nof\tO\nestrogen\tB-Chemical\n-\tO\ninduced\tO\nadenohypophyseal\tB-Disease\ntumors\tI-Disease\nin\tO\nthe\tO\nFischer\tO\n344\tO\nrat\tO\n.\tO\n\nPituitary\tB-Disease\ntumors\tI-Disease\nwere\tO\ninduced\tO\nin\tO\nF344\tO\nfemale\tO\nrats\tO\nby\tO\nchronic\tO\ntreatment\tO\nwith\tO\ndiethylstilbestrol\tB-Chemical\n(\tO\nDES\tB-Chemical\n,\tO\n8\tO\n-\tO\n10\tO\nmg\tO\n)\tO\nimplanted\tO\nsubcutaneously\tO\nin\tO\nsilastic\tO\ncapsules\tO\n.\tO\n\nOver\tO\na\tO\nrange\tO\nof\tO\n1\tO\n-\tO\n150\tO\ndays\tO\nof\tO\nDES\tB-Chemical\ntreatment\tO\n,\tO\npairs\tO\nof\tO\ncontrol\tO\nand\tO\nDES\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nwere\tO\nsacrificed\tO\n,\tO\nand\tO\ntheir\tO\npituitaries\tO\ndissociated\tO\nenzymatically\tO\ninto\tO\nsingle\tO\n-\tO\ncell\tO\npreparations\tO\n.\tO\n\nThe\tO\ncell\tO\npopulations\tO\nwere\tO\nexamined\tO\nregarding\tO\ntotal\tO\ncell\tO\nrecovery\tO\ncorrelated\tO\nwith\tO\ngland\tO\nweight\tO\n,\tO\nintracellular\tO\nprolactin\tO\n(\tO\nPRL\tO\n)\tO\ncontent\tO\nand\tO\nsubsequent\tO\nrelease\tO\nin\tO\nprimary\tO\nculture\tO\n,\tO\nimmunocytochemical\tO\nPRL\tO\nstaining\tO\n,\tO\ndensity\tO\nand\tO\n/\tO\nor\tO\nsize\tO\nalterations\tO\nvia\tO\nseparation\tO\non\tO\nFicoll\tO\n-\tO\nHypaque\tO\nand\tO\nby\tO\nunit\tO\ngravity\tO\nsedimentation\tO\n,\tO\nand\tO\ncell\tO\ncycle\tO\nanalysis\tO\n,\tO\nafter\tO\nacriflavine\tB-Chemical\nDNA\tO\nstaining\tO\n,\tO\nby\tO\nlaser\tO\nflow\tO\ncytometry\tO\n.\tO\n\nTotal\tO\ncell\tO\nyields\tO\nfrom\tO\nDES\tB-Chemical\n-\tO\ntreated\tO\npituitaries\tO\nincreased\tO\nfrom\tO\n1\tO\n.\tO\n3\tO\ntimes\tO\ncontrol\tO\nyields\tO\nat\tO\n8\tO\ndays\tO\nof\tO\ntreatment\tO\nto\tO\n58\tO\n.\tO\n9\tO\ntimes\tO\ncontrol\tO\nvalues\tO\nby\tO\nday\tO\n150\tO\n.\tO\n\nIntracellular\tO\nPRL\tO\ncontent\tO\nranged\tO\nfrom\tO\n1\tO\n.\tO\n9\tO\nto\tO\n9\tO\n.\tO\n4\tO\ntimes\tO\ncontrol\tO\nlevels\tO\n,\tO\nand\tO\nPRL\tO\nrelease\tO\nin\tO\nvitro\tO\nwas\tO\nsignificantly\tO\nand\tO\nconsistently\tO\nhigher\tO\nthan\tO\ncontrols\tO\n,\tO\nafter\tO\nat\tO\nleast\tO\n8\tO\ndays\tO\nof\tO\nDES\tB-Chemical\nexposure\tO\n.\tO\n\nBeyond\tO\n8\tO\ndays\tO\nof\tO\nDES\tB-Chemical\nexposure\tO\n,\tO\nthe\tO\nimmunochemically\tO\nPRL\tO\n-\tO\npositive\tO\nproportion\tO\nof\tO\ncells\tO\nincreased\tO\nto\tO\nover\tO\n50\tO\n%\tO\nof\tO\nthe\tO\ntotal\tO\npopulation\tO\n.\tO\n\nIncreased\tO\ndensity\tO\nand\tO\n/\tO\nor\tO\nsize\tO\nand\tO\nPRL\tO\ncontent\tO\nwere\tO\nindicated\tO\nfor\tO\nthe\tO\nmajority\tO\nof\tO\nthe\tO\nPRL\tO\ncell\tO\npopulation\tO\nin\tO\nboth\tO\ntypes\tO\nof\tO\nseparation\tO\nprotocols\tO\n.\tO\n\nAll\tO\nthese\tO\neffects\tO\nof\tO\nDES\tB-Chemical\nwere\tO\nmore\tO\npronounced\tO\namong\tO\npreviously\tO\novariectomized\tO\nanimals\tO\n.\tO\n\nThe\tO\ndata\tO\nextend\tO\nthe\tO\nfindings\tO\nof\tO\nother\tO\ninvestigators\tO\n,\tO\nfurther\tO\nestablishing\tO\nthe\tO\nDES\tB-Chemical\n-\tO\ninduced\tO\ntumor\tB-Disease\nas\tO\na\tO\nmodel\tO\nfor\tO\nstudy\tO\nof\tO\nPRL\tO\ncellular\tO\ncontrol\tO\nmechanisms\tO\n.\tO\n\nAge\tO\nand\tO\nrenal\tO\nclearance\tO\nof\tO\ncimetidine\tB-Chemical\n.\tO\n\nIn\tO\n35\tO\npatients\tO\n(\tO\nages\tO\n20\tO\nto\tO\n86\tO\nyr\tO\n)\tO\nreceiving\tO\ncimetidine\tB-Chemical\ntherapeutically\tO\ntwo\tO\nserum\tO\nsamples\tO\nand\tO\nall\tO\nurine\tO\nformed\tO\nin\tO\nthe\tO\ninterim\tO\nwere\tO\ncollected\tO\nfor\tO\nanalysis\tO\nof\tO\ncimetidine\tB-Chemical\nby\tO\nhigh\tO\n-\tO\npressure\tO\nliquid\tO\nchromatography\tO\nand\tO\nfor\tO\ncreatinine\tB-Chemical\n.\tO\n\nCimetidine\tB-Chemical\nclearance\tO\ndecreased\tO\nwith\tO\nage\tO\n.\tO\n\nThe\tO\nextrapolated\tO\n6\tO\n-\tO\nhr\tO\nserum\tO\nconcentration\tO\nof\tO\ncimetidine\tB-Chemical\nper\tO\nunit\tO\ndose\tO\n,\tO\nafter\tO\nintravenous\tO\ncimetidine\tB-Chemical\n,\tO\nincreased\tO\nwith\tO\nage\tO\nof\tO\nthe\tO\npatients\tO\n.\tO\n\nThe\tO\nratio\tO\nof\tO\ncimetidine\tB-Chemical\nclearance\tO\nto\tO\ncreatinine\tB-Chemical\nclearance\tO\n(\tO\nRc\tO\n)\tO\naveraged\tO\n4\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n0\tO\n,\tO\nindicating\tO\nnet\tO\ntubular\tO\nsecretion\tO\nfor\tO\ncimetidine\tB-Chemical\n.\tO\n\nRc\tO\nseemed\tO\nto\tO\nbe\tO\nindependent\tO\nof\tO\nage\tO\nand\tO\ndecreased\tO\nwith\tO\nincreasing\tO\nserum\tO\nconcentration\tO\nof\tO\ncimetidine\tB-Chemical\n,\tO\nsuggesting\tO\nthat\tO\nsecretion\tO\nof\tO\ncimetidine\tB-Chemical\nis\tO\na\tO\nsaturable\tO\nprocess\tO\n.\tO\n\nThere\tO\nwas\tO\nonly\tO\none\tO\ncase\tO\nof\tO\ndementia\tB-Disease\npossibly\tO\ndue\tO\nto\tO\ncimetidine\tB-Chemical\n(\tO\nwith\tO\na\tO\ndrug\tO\nlevel\tO\nof\tO\n1\tO\n.\tO\n9\tO\nmicrogram\tO\n/\tO\nml\tO\n6\tO\nhr\tO\nafter\tO\na\tO\ndose\tO\n)\tO\nin\tO\na\tO\ngroup\tO\nof\tO\n13\tO\npatients\tO\nwithout\tO\nliver\tB-Disease\nor\tI-Disease\nkidney\tI-Disease\ndisease\tI-Disease\nwho\tO\nhad\tO\ncimetidine\tB-Chemical\nlevels\tO\nabove\tO\n1\tO\n.\tO\n25\tO\nmicrogram\tO\n/\tO\nml\tO\n.\tO\n\nThus\tO\n,\tO\nhigh\tO\ncimetidine\tB-Chemical\nlevels\tO\nalone\tO\ndo\tO\nnot\tO\nalways\tO\ninduce\tO\ndementia\tB-Disease\n.\tO\n\nFurther\tO\nobservations\tO\non\tO\nthe\tO\nelectrophysiologic\tO\neffects\tO\nof\tO\noral\tO\namiodarone\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\ncase\tO\nis\tO\npresented\tO\nof\tO\na\tO\nreversible\tO\nintra\tB-Disease\n-\tI-Disease\nHisian\tI-Disease\nblock\tI-Disease\noccurring\tO\nunder\tO\namiodarone\tB-Chemical\ntreatment\tO\nfor\tO\natrial\tB-Disease\ntachycardia\tI-Disease\nin\tO\na\tO\npatient\tO\nwithout\tO\nclear\tO\nintraventricular\tB-Disease\nconduction\tI-Disease\nabnormalities\tI-Disease\n.\tO\n\nHis\tO\nbundle\tO\nrecordings\tO\nshowed\tO\nan\tO\natrial\tB-Disease\ntachycardia\tI-Disease\nwith\tO\nintermittent\tO\nexit\tO\nblock\tO\nand\tO\ngreatly\tO\nprolonged\tO\nBH\tO\nand\tO\nHV\tO\nintervals\tO\n(\tO\n40\tO\nand\tO\n100\tO\nmsec\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nThirty\tO\ndays\tO\nafter\tO\namiodarone\tB-Chemical\ndiscontinuation\tO\n,\tO\nHis\tO\nbundle\tO\nelectrograms\tO\nshowed\tO\natrial\tB-Disease\nflutter\tI-Disease\nwithout\tO\nintra\tO\n-\tO\nHisian\tO\nor\tO\ninfra\tO\n-\tO\nHisian\tO\ndelay\tO\n.\tO\n\nAmiodarone\tB-Chemical\nshould\tO\nbe\tO\nused\tO\nwith\tO\ncaution\tO\nduring\tO\nlong\tO\n-\tO\nterm\tO\noral\tO\ntherapy\tO\nin\tO\npatients\tO\nwith\tO\nor\tO\nwithout\tO\nclear\tO\nintraventricular\tO\nconduction\tO\ndefects\tO\n.\tO\n\nDevelopment\tO\nof\tO\nclear\tB-Disease\ncell\tI-Disease\nadenocarcinoma\tI-Disease\nin\tO\nDES\tB-Chemical\n-\tO\nexposed\tO\noffspring\tO\nunder\tO\nobservation\tO\n.\tO\n\nTwo\tO\ncases\tO\nof\tO\nclear\tB-Disease\ncell\tI-Disease\nadenocarcinoma\tI-Disease\nof\tI-Disease\nthe\tI-Disease\nvagina\tI-Disease\ndetected\tO\nat\tO\nfollow\tO\n-\tO\nup\tO\nin\tO\nyoung\tO\nwomen\tO\nexposed\tO\nin\tO\nutero\tO\nto\tO\ndiethylstilbestrol\tB-Chemical\nare\tO\nreported\tO\n.\tO\n\nOne\tO\npatient\tO\n,\tO\naged\tO\n23\tO\n,\tO\nhad\tO\nbeen\tO\nfollowed\tO\nfor\tO\n2\tO\nyears\tO\nbefore\tO\ncarcinoma\tB-Disease\nwas\tO\ndiagnosed\tO\n;\tO\nthe\tO\nsecond\tO\npatient\tO\n,\tO\naged\tO\n22\tO\n,\tO\nhad\tO\nbeen\tO\nseen\tO\non\tO\na\tO\nregular\tO\nbasis\tO\nfor\tO\n5\tO\nyears\tO\n,\tO\n8\tO\nmonths\tO\n.\tO\n\nIn\tO\nboth\tO\ninstances\tO\n,\tO\nsuspicion\tO\nof\tO\nthe\tO\npresence\tO\nof\tO\ncarcinoma\tB-Disease\nwas\tO\naroused\tO\nby\tO\nthe\tO\npalpation\tO\nof\tO\na\tO\nsmall\tO\nnodule\tO\nin\tO\nthe\tO\nvaginal\tO\nfornix\tO\n.\tO\n\nHysterosalpingography\tO\nwas\tO\nperformed\tO\non\tO\nboth\tO\npatients\tO\nand\tO\n,\tO\nin\tO\n1\tO\ninstance\tO\n,\tO\nan\tO\nabnormal\tO\nx\tO\n-\tO\nray\tO\nfilm\tO\nwas\tO\nreflected\tO\nby\tO\nthe\tO\ngross\tO\nappearance\tO\nof\tO\nthe\tO\nuterine\tO\ncavity\tO\nfound\tO\nin\tO\nthe\tO\nsurgical\tO\nspecimen\tO\n.\tO\n\nNeurologic\tO\neffects\tO\nof\tO\nsubarachnoid\tO\nadministration\tO\nof\tO\n2\tB-Chemical\n-\tI-Chemical\nchloroprocaine\tI-Chemical\n-\tI-Chemical\nCE\tI-Chemical\n,\tO\nbupivacaine\tB-Chemical\n,\tO\nand\tO\nlow\tO\npH\tO\nnormal\tO\nsaline\tO\nin\tO\ndogs\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nevaluate\tO\nthe\tO\nneurologic\tO\nconsequences\tO\nof\tO\ndeliberate\tO\nsubarachnoid\tO\ninjection\tO\nof\tO\nlarge\tO\nvolumes\tO\nof\tO\n2\tB-Chemical\n-\tI-Chemical\nchloroprocaine\tI-Chemical\n-\tI-Chemical\nCE\tI-Chemical\nin\tO\nexperimental\tO\nanimals\tO\n.\tO\n\nThe\tO\npossible\tO\nrole\tO\nof\tO\nlow\tO\npH\tO\nas\tO\nwell\tO\nas\tO\ntotal\tO\nvolume\tO\nas\tO\npotential\tO\nfactors\tO\nin\tO\ncausing\tO\nneurotoxicity\tB-Disease\nwas\tO\nevaluated\tO\n.\tO\n\nThe\tO\n65\tO\ndogs\tO\nin\tO\nthe\tO\nstudy\tO\nreceived\tO\ninjections\tO\nin\tO\nthe\tO\nsubarachnoid\tO\nspace\tO\nas\tO\nfollows\tO\n:\tO\n6\tO\nto\tO\n8\tO\nml\tO\nof\tO\nbupivacaine\tB-Chemical\n(\tO\nN\tO\n=\tO\n15\tO\n)\tO\n,\tO\n2\tB-Chemical\n-\tI-Chemical\nchloroprocaine\tI-Chemical\n-\tI-Chemical\nCE\tI-Chemical\n(\tO\nN\tO\n=\tO\n20\tO\n)\tO\n,\tO\nlow\tO\npH\tO\nnormal\tO\nsaline\tO\n(\tO\npH\tO\n3\tO\n.\tO\n0\tO\n)\tO\n(\tO\nN\tO\n=\tO\n20\tO\n)\tO\n,\tO\nor\tO\nnormal\tO\nsaline\tO\n(\tO\nN\tO\n=\tO\n10\tO\n)\tO\n.\tO\n\nOf\tO\nthe\tO\n20\tO\nanimals\tO\nthat\tO\nreceived\tO\nsubarachnoid\tO\ninjection\tO\nof\tO\n2\tB-Chemical\n-\tI-Chemical\nchloroprocaine\tI-Chemical\n-\tI-Chemical\nCE\tI-Chemical\nseven\tO\n(\tO\n35\tO\n%\tO\n)\tO\ndeveloped\tO\nhind\tO\n-\tO\nlimb\tO\nparalysis\tB-Disease\n.\tO\n\nNone\tO\nof\tO\nthe\tO\nanimals\tO\nthat\tO\nreceived\tO\nbupivacaine\tB-Chemical\n,\tO\nnormal\tO\nsaline\tO\n,\tO\nor\tO\nnormal\tO\nsaline\tO\ntitrated\tO\nto\tO\na\tO\npH\tO\n3\tO\n.\tO\n0\tO\ndeveloped\tO\nhind\tO\n-\tO\nlimb\tO\nparalysis\tB-Disease\n.\tO\n\nOf\tO\nthe\tO\n15\tO\nspinal\tO\ncords\tO\nof\tO\nthe\tO\nanimals\tO\nthat\tO\nreceived\tO\n2\tB-Chemical\n-\tI-Chemical\nchloroprocaine\tI-Chemical\n-\tI-Chemical\nCE\tI-Chemical\n,\tO\n13\tO\nshowed\tO\nsubpial\tB-Disease\nnecrosis\tI-Disease\n;\tO\nthe\tO\nnerve\tO\nroots\tO\nand\tO\nsubarachnoid\tO\nvessels\tO\nwere\tO\nnormal\tO\n.\tO\n\nThe\tO\nspinal\tO\ncords\tO\nof\tO\nthe\tO\nanimals\tO\nthat\tO\nreceived\tO\nbupivacaine\tB-Chemical\n,\tO\nlow\tO\npH\tO\nnormal\tO\nsaline\tO\n(\tO\npH\tO\n3\tO\n.\tO\n0\tO\n)\tO\n,\tO\nor\tO\nnormal\tO\nsaline\tO\ndid\tO\nnot\tO\nshow\tO\nabnormal\tO\nfindings\tO\n.\tO\n\nProcainamide\tB-Chemical\n-\tO\ninduced\tO\npolymorphous\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n.\tO\n\nSeven\tO\ncases\tO\nof\tO\nprocainamide\tB-Chemical\n-\tO\ninduced\tO\npolymorphous\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nare\tO\npresented\tO\n.\tO\n\nIn\tO\nfour\tO\npatients\tO\n,\tO\npolymorphous\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nappeared\tO\nafter\tO\nintravenous\tO\nadministration\tO\nof\tO\n200\tO\nto\tO\n400\tO\nmg\tO\nof\tO\nprocainamide\tB-Chemical\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nsustained\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n.\tO\n\nIn\tO\nthe\tO\nremaining\tO\nthree\tO\npatients\tO\n,\tO\nprocainamide\tB-Chemical\nwas\tO\nadministered\tO\norally\tO\nfor\tO\ntreatment\tO\nof\tO\nchronic\tO\npremature\tB-Disease\nventricular\tI-Disease\ncontractions\tI-Disease\nor\tO\natrial\tB-Disease\nflutter\tI-Disease\n.\tO\n\nThese\tO\npatients\tO\nhad\tO\nQ\tB-Disease\n-\tI-Disease\nT\tI-Disease\nprolongation\tI-Disease\nand\tO\nrecurrent\tO\nsyncope\tB-Disease\ndue\tO\nto\tO\npolymorphous\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n.\tO\n\nIn\tO\nfour\tO\npatients\tO\n,\tO\nthe\tO\narrhythmia\tB-Disease\nwas\tO\nrapidly\tO\ndiagnosed\tO\nand\tO\ntreated\tO\nwith\tO\ndisappearance\tO\nof\tO\nfurther\tO\nepisodes\tO\nof\tO\nthe\tO\narrhythmia\tB-Disease\n.\tO\n\nIn\tO\ntwo\tO\npatients\tO\n,\tO\nthe\tO\narrhythmia\tB-Disease\ndegenerated\tO\ninto\tO\nirreversible\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nand\tO\nboth\tO\npatients\tO\ndied\tO\n.\tO\n\nIn\tO\nthe\tO\nseventh\tO\npatient\tO\n,\tO\na\tO\npermanent\tO\nventricular\tO\npacemaker\tO\nwas\tO\ninserted\tO\nand\tO\n,\tO\ndespite\tO\ncontinuation\tO\nof\tO\nprocainamide\tB-Chemical\ntherapy\tO\n,\tO\npolymorphous\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\ndid\tO\nnot\tO\nreoccur\tO\n.\tO\n\nThese\tO\nseven\tO\ncases\tO\ndemonstrate\tO\nthat\tO\nprocainamide\tB-Chemical\ncan\tO\nproduce\tO\nan\tO\nacquired\tO\nprolonged\tB-Disease\nQ\tI-Disease\n-\tI-Disease\nT\tI-Disease\nsyndrome\tI-Disease\nwith\tO\npolymorphous\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n.\tO\n\nPhenobarbitone\tB-Chemical\n-\tO\ninduced\tO\nenlargement\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nliver\tI-Disease\nin\tO\nthe\tO\nrat\tO\n:\tO\nits\tO\nrelationship\tO\nto\tO\ncarbon\tB-Chemical\ntetrachloride\tI-Chemical\n-\tO\ninduced\tO\ncirrhosis\tB-Disease\n.\tO\n\nThe\tO\nyield\tO\nof\tO\nsevere\tO\ncirrhosis\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nliver\tI-Disease\n(\tO\ndefined\tO\nas\tO\na\tO\nshrunken\tO\nfinely\tO\nnodular\tO\nliver\tO\nwith\tO\nmicronodular\tO\nhistology\tO\n,\tO\nascites\tB-Disease\ngreater\tO\nthan\tO\n30\tO\nml\tO\n,\tO\nplasma\tO\nalbumin\tO\nless\tO\nthan\tO\n2\tO\n.\tO\n2\tO\ng\tO\n/\tO\ndl\tO\n,\tO\nsplenomegaly\tB-Disease\n2\tO\n-\tO\n3\tO\ntimes\tO\nnormal\tO\n,\tO\nand\tO\ntesticular\tO\natrophy\tB-Disease\napproximately\tO\nhalf\tO\nnormal\tO\nweight\tO\n)\tO\nafter\tO\n12\tO\ndoses\tO\nof\tO\ncarbon\tB-Chemical\ntetrachloride\tI-Chemical\ngiven\tO\nintragastrically\tO\nin\tO\nthe\tO\nphenobarbitone\tB-Chemical\n-\tO\nprimed\tO\nrat\tO\nwas\tO\nincreased\tO\nfrom\tO\n25\tO\n%\tO\nto\tO\n56\tO\n%\tO\nby\tO\ngiving\tO\nthe\tO\ninitial\tO\n\"\tO\ncalibrating\tO\n\"\tO\ndose\tO\nof\tO\ncarbon\tB-Chemical\ntetrachloride\tI-Chemical\nat\tO\nthe\tO\npeak\tO\nof\tO\nthe\tO\nphenobarbitone\tB-Chemical\n-\tO\ninduced\tO\nenlargement\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nliver\tI-Disease\n.\tO\n\nAt\tO\nthis\tO\npoint\tO\nit\tO\nwas\tO\nassumed\tO\nthat\tO\nthe\tO\ncytochrome\tO\nP450\tO\n/\tO\nCCl4\tB-Chemical\ntoxic\tO\nstate\tO\nwas\tO\nboth\tO\nmaximal\tO\nand\tO\nstable\tO\n.\tO\n\nThe\tO\noptimal\tO\nrat\tO\nsize\tO\nto\tO\nbegin\tO\nphenobarbitone\tB-Chemical\nwas\tO\ndetermined\tO\nas\tO\n100\tO\ng\tO\n,\tO\nand\tO\nthis\tO\nsize\tO\nas\tO\na\tO\ngroup\tO\nhad\tO\na\tO\nmean\tO\nmaximum\tO\nrelative\tO\nliver\tO\nweight\tO\nincrease\tO\n47\tO\n%\tO\ngreater\tO\nthan\tO\nnormal\tO\nrats\tO\nof\tO\nthe\tO\nsame\tO\nbody\tO\nweight\tO\n.\tO\n\nThe\tO\noptimal\tO\ntime\tO\nfor\tO\nthe\tO\ninitial\tO\ndose\tO\nof\tO\ncarbon\tB-Chemical\ntetrachloride\tI-Chemical\nwas\tO\nafter\tO\n14\tO\ndays\tO\non\tO\nphenobarbitone\tB-Chemical\n.\tO\n\nTriamterene\tB-Chemical\nnephrolithiasis\tB-Disease\ncomplicating\tO\ndyazide\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\ncase\tO\nof\tO\ntriamterene\tB-Chemical\nnephrolithiasis\tB-Disease\nis\tO\nreported\tO\nin\tO\na\tO\nman\tO\nafter\tO\n4\tO\nyears\tO\nof\tO\nhydrochlorothiazide\tB-Chemical\n-\tI-Chemical\ntriamterene\tI-Chemical\ntherapy\tO\nfor\tO\nhypertension\tB-Disease\n.\tO\n\nThe\tO\nstone\tO\npassed\tO\nspontaneously\tO\nand\tO\nwas\tO\nfound\tO\nto\tO\ncontain\tO\na\tO\ntriamterene\tB-Chemical\nmetabolite\tO\nadmixed\tO\nwith\tO\nuric\tB-Chemical\nacid\tI-Chemical\nsalts\tI-Chemical\n.\tO\n\nFactors\tO\naffecting\tO\ntriamterene\tB-Chemical\nnephrolithiasis\tB-Disease\nare\tO\ndiscussed\tO\nand\tO\n2\tO\npreviously\tO\nreported\tO\ncases\tO\nare\tO\nreviewed\tO\n.\tO\n\nBusulfan\tB-Chemical\n-\tO\ninduced\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\n.\tO\n\nA\tO\ncase\tO\nof\tO\na\tO\nbusulfan\tB-Chemical\n-\tO\ninduced\tO\nhemorrhage\tB-Disease\ncystitis\tI-Disease\nis\tO\nreported\tO\n.\tO\n\nSpontaneous\tO\nresolution\tO\noccurred\tO\nfollowing\tO\ncessation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nThe\tO\nsimilarity\tO\nbetween\tO\nthe\tO\nhistologic\tO\nappearances\tO\nof\tO\nbusulfan\tB-Chemical\ncystitis\tB-Disease\nand\tO\nboth\tO\nradiation\tO\nand\tO\ncyclophosphamide\tB-Chemical\n-\tO\ninduced\tO\ncystitis\tB-Disease\nis\tO\ndiscussed\tO\nand\tO\nthe\tO\nworld\tO\nliterature\tO\nreviewed\tO\n.\tO\n\nIn\tO\nview\tO\nof\tO\nthe\tO\nknown\tO\ntendency\tO\nof\tO\nbusulfan\tB-Chemical\nto\tO\ninduce\tO\ncellular\tO\natypia\tO\nand\tO\ncarcinoma\tB-Disease\nin\tO\nother\tO\nsites\tO\n,\tO\nperiodic\tO\nurinary\tO\ncytology\tO\nis\tO\nsuggested\tO\nin\tO\npatients\tO\non\tO\nlong\tO\n-\tO\nterm\tO\ntherapy\tO\n.\tO\n\nVariant\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nin\tO\ndesipramine\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nvariant\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\ninduced\tO\nby\tO\ndesipramine\tB-Chemical\ntoxicity\tB-Disease\n.\tO\n\nUnusual\tO\nfeatures\tO\nof\tO\nthe\tO\narrhythmia\tB-Disease\nare\tO\nrepetitive\tO\ngroup\tO\nbeating\tO\n,\tO\nprogressive\tO\nshortening\tO\nof\tO\nthe\tO\nR\tO\n-\tO\nR\tO\ninterval\tO\n,\tO\nprogressive\tO\nwidening\tO\nof\tO\nthe\tO\nQRS\tO\ncomplex\tO\nwith\tO\neventual\tO\nfailure\tO\nof\tO\nintraventricular\tO\nconduction\tO\n,\tO\nand\tO\nchanges\tO\nin\tO\ndirection\tO\nof\tO\nthe\tO\nQRS\tO\naxis\tO\n.\tO\n\nRecognition\tO\nof\tO\nvariant\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\nis\tO\nimportant\tO\nbecause\tO\ntherapy\tO\ndiffers\tO\nfrom\tO\nthat\tO\nof\tO\nclassic\tO\nventricular\tB-Disease\ntachycardia\tI-Disease\n.\tO\n\nRebound\tO\nhypertensive\tB-Disease\nafter\tO\nsodium\tB-Chemical\nnitroprusside\tI-Chemical\nprevented\tO\nby\tO\nsaralasin\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nThe\tO\nrole\tO\nof\tO\nthe\tO\nrenin\tO\n-\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\nin\tO\nthe\tO\nmaintenance\tO\nof\tO\nblood\tO\npressure\tO\nduring\tO\nhalothane\tB-Chemical\nanesthesia\tO\nand\tO\nsodium\tB-Chemical\nnitroprusside\tI-Chemical\n(\tO\nSNP\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\nwas\tO\nevaluated\tO\n.\tO\n\nControl\tO\nrats\tO\nreceived\tO\nhalothane\tB-Chemical\nanesthesia\tO\n(\tO\n1\tO\nMAC\tO\n)\tO\nfor\tO\none\tO\nhour\tO\n,\tO\nfollowed\tO\nby\tO\nSNP\tB-Chemical\ninfusion\tO\n,\tO\n40\tO\nmicrogram\tO\n/\tO\nkg\tO\n/\tO\nmin\tO\n,\tO\nfor\tO\n30\tO\nmin\tO\n,\tO\nfollowed\tO\nby\tO\na\tO\n30\tO\n-\tO\nmin\tO\nrecovery\tO\nperiod\tO\n.\tO\n\nA\tO\nsecond\tO\ngroup\tO\nof\tO\nrats\tO\nwas\tO\ntreated\tO\nidentically\tO\nand\tO\n,\tO\nin\tO\naddition\tO\n,\tO\nreceived\tO\nan\tO\ninfusion\tO\nof\tO\nsaralasin\tB-Chemical\n(\tO\na\tO\ncompetitive\tO\ninhibitor\tO\nof\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\n)\tO\nthroughout\tO\nthe\tO\nexperimental\tO\nperiod\tO\n.\tO\n\nIn\tO\neach\tO\ngroup\tO\n,\tO\nSNP\tB-Chemical\ninfusion\tO\nresulted\tO\nin\tO\nan\tO\ninitial\tO\ndecrease\tO\nin\tO\nblood\tO\npressure\tO\nfrom\tO\n86\tO\ntorr\tO\nand\tO\n83\tO\ntorr\tO\n,\tO\nrespectively\tO\n,\tO\nto\tO\n48\tO\ntorr\tO\n.\tO\n\nDuring\tO\nthe\tO\nSNP\tB-Chemical\ninfusion\tO\nthe\tO\ncontrol\tO\nanimals\tO\ndemonstrated\tO\na\tO\nprogressive\tO\nincrease\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nto\tO\n61\tO\ntorr\tO\n,\tO\nwhereas\tO\nthe\tO\nsaralasin\tB-Chemical\n-\tO\ntreated\tO\nanimals\tO\nshowed\tO\nno\tO\nchange\tO\n.\tO\n\nFollowing\tO\ndiscontinuation\tO\nof\tO\nSNP\tB-Chemical\n,\tO\nblood\tO\npressure\tO\nin\tO\nthe\tO\ncontrol\tO\nanimals\tO\nrebounded\tO\nto\tO\n94\tO\ntorr\tO\n,\tO\nas\tO\ncompared\tO\nwith\tO\n78\tO\ntorr\tO\nin\tO\nthe\tO\nsaralasin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nThis\tO\nstudy\tO\nindicates\tO\nthat\tO\nwith\tO\nstable\tO\nhalothane\tB-Chemical\nanesthesia\tO\n,\tO\nthe\tO\npartial\tO\nrecovery\tO\nof\tO\nblood\tO\npressure\tO\nduring\tO\nSNP\tB-Chemical\ninfusion\tO\nand\tO\nthe\tO\npost\tO\n-\tO\nSNP\tB-Chemical\nrebound\tO\nof\tO\nblood\tO\npressure\tO\ncan\tO\nbe\tO\ncompletely\tO\nblocked\tO\nby\tO\nsaralasin\tB-Chemical\n.\tO\n\nThis\tO\ndemonstrates\tO\nthe\tO\nparticipation\tO\nof\tO\nthe\tO\nrenin\tO\n-\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\nin\tO\nantagonizing\tO\nthe\tO\ncombined\tO\nhypotensive\tB-Disease\neffects\tO\nof\tO\nhalothane\tB-Chemical\nand\tO\nSNP\tB-Chemical\n.\tO\n\nClinical\tO\nnephrotoxicity\tB-Disease\nof\tO\ntobramycin\tB-Chemical\nand\tO\ngentamicin\tB-Chemical\n.\tO\n\nA\tO\nprospective\tO\nstudy\tO\n.\tO\n\nNearly\tO\n3\tO\n.\tO\n2\tO\nmillion\tO\npeople\tO\nin\tO\nthis\tO\ncountry\tO\nreceive\tO\naminoglycoside\tB-Chemical\nantibiotics\tO\nannually\tO\n.\tO\n\nGentamicin\tB-Chemical\nsulfate\tI-Chemical\nand\tO\ntobramycin\tB-Chemical\nsulfate\tI-Chemical\ncontinue\tO\nto\tO\ndemonstrate\tO\nototoxicity\tB-Disease\nand\tO\nnephrotoxicity\tB-Disease\nin\tO\nboth\tO\nanimal\tO\nand\tO\nclinical\tO\nstudies\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\n62\tO\npatients\tO\nwith\tO\nconfirmed\tO\ninitial\tO\nnormal\tO\nrenal\tO\nfunction\tO\nand\tO\ntreated\tO\nwith\tO\n2\tO\nto\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nof\tO\ngentamicin\tB-Chemical\nsulfate\tI-Chemical\nor\tO\ntobramycin\tB-Chemical\nsulfate\tI-Chemical\nfor\tO\na\tO\nminimum\tO\nof\tO\nseven\tO\ndays\tO\nwere\tO\nfollowed\tO\nup\tO\nprospectively\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\naminoglycoside\tB-Chemical\n-\tO\nrelated\tO\nrenal\tB-Disease\nfailure\tI-Disease\n,\tO\ndefined\tO\nas\tO\nat\tO\nleast\tO\na\tO\none\tO\n-\tO\nthird\tO\nreduction\tO\nin\tO\nrenal\tO\nfunction\tO\n.\tO\n\nIn\tO\nthese\tO\n62\tO\npatients\tO\n,\tO\nno\tO\nother\tO\ncauses\tO\nfor\tO\nrenal\tB-Disease\nfailure\tI-Disease\ncould\tO\nbe\tO\nidentified\tO\n.\tO\n\nFive\tO\nof\tO\n33\tO\n(\tO\n15\tO\n%\tO\n)\tO\nof\tO\nthe\tO\ntobramycin\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nand\tO\n16\tO\nof\tO\n29\tO\n(\tO\n55\tO\n.\tO\n2\tO\n%\tO\n)\tO\nof\tO\nthe\tO\ngentamicin\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nhad\tO\nrenal\tB-Disease\nfailure\tI-Disease\n.\tO\n\nThus\tO\n,\tO\ngentamicin\tB-Chemical\nwas\tO\nassociated\tO\nwith\tO\nrenal\tB-Disease\nfailure\tI-Disease\nmore\tO\nthan\tO\nthree\tO\ntimes\tO\nas\tO\noften\tO\nas\tO\nwas\tO\ntobramycin\tB-Chemical\n.\tO\n\nMetabolic\tO\ninvolvement\tO\nin\tO\nadriamycin\tB-Chemical\ncardiotoxicity\tB-Disease\n.\tO\n\nThe\tO\ncardiotoxic\tB-Disease\neffects\tO\nof\tO\nadriamycin\tB-Chemical\nwere\tO\nstudied\tO\nin\tO\nmammalian\tO\nmyocardial\tO\ncells\tO\nin\tO\nculture\tO\nas\tO\na\tO\nmodel\tO\nsystem\tO\n.\tO\n\nAdriamycin\tB-Chemical\ninhibited\tO\ncell\tO\ngrowth\tO\nand\tO\nthe\tO\nrhythmic\tO\ncontractions\tO\ncharacteristic\tO\nof\tO\nmyocardial\tO\ncells\tO\nin\tO\nculture\tO\n.\tO\n\nA\tO\npossible\tO\ninvolvement\tO\nof\tO\nenergy\tO\nmetabolism\tO\nwas\tO\nsuggested\tO\npreviously\tO\n,\tO\nand\tO\nin\tO\nthis\tO\nstudy\tO\nthe\tO\nadenylate\tO\nenergy\tO\ncharge\tO\nand\tO\nphosphorylcreatine\tB-Chemical\nmole\tO\nfraction\tO\nwere\tO\ndetermined\tO\nin\tO\nthe\tO\nadriamycin\tB-Chemical\n-\tO\ntreated\tO\ncells\tO\n.\tO\n\nThe\tO\nadenylate\tO\nenergy\tO\ncharge\tO\nwas\tO\nfound\tO\nto\tO\nbe\tO\nsignificantly\tO\ndecreased\tO\n,\tO\nwhile\tO\nthe\tO\nphophorylcreatine\tB-Chemical\nmole\tO\nfraction\tO\nwas\tO\nunchanged\tO\n.\tO\n\nSuch\tO\ndisparity\tO\nsuggests\tO\nan\tO\ninhibition\tO\nof\tO\ncreatine\tB-Chemical\nphosphokinase\tO\n.\tO\n\nThe\tO\naddition\tO\nof\tO\n1\tO\nmM\tO\nadenosine\tB-Chemical\nto\tO\nthe\tO\nmyocardial\tO\ncell\tO\ncultures\tO\nmarkedly\tO\nincreases\tO\nthe\tO\nATP\tB-Chemical\nconcentration\tO\nthrough\tO\na\tO\npathway\tO\nreportedly\tO\nleading\tO\nto\tO\na\tO\ncompartmentalized\tO\nATP\tB-Chemical\npool\tO\n.\tO\n\nIn\tO\nthe\tO\nadriamycin\tB-Chemical\n-\tO\ntreated\tO\ncells\tO\n,\tO\nthe\tO\naddition\tO\nof\tO\nadenosine\tB-Chemical\nincreased\tO\nthe\tO\nadenylate\tO\ncharge\tO\nand\tO\n,\tO\nconcomitant\tO\nwith\tO\nthis\tO\ninrcease\tO\n,\tO\nthe\tO\ncells\tO\n'\tO\nfunctional\tO\nintegrity\tO\n,\tO\nin\tO\nterms\tO\nof\tO\npercentage\tO\nof\tO\nbeating\tO\ncells\tO\nand\tO\nrate\tO\nof\tO\ncontractions\tO\n,\tO\nwas\tO\nmaintained\tO\n.\tO\n\nAge\tO\n-\tO\ndependent\tO\nsensitivity\tO\nof\tO\nthe\tO\nrat\tO\nto\tO\nneurotoxic\tB-Disease\neffects\tO\nof\tO\nstreptomycin\tB-Chemical\n.\tO\n\nStreptomycin\tB-Chemical\nsulfate\tO\n(\tO\n300\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\n)\tO\nwas\tO\ninjected\tO\nfor\tO\nvarious\tO\nperiods\tO\ninto\tO\npreweanling\tO\nrats\tO\nand\tO\nfor\tO\n3\tO\nweeks\tO\ninto\tO\nweanling\tO\nrats\tO\n.\tO\n\nBeginning\tO\nat\tO\n8\tO\ndays\tO\nof\tO\nage\tO\n,\tO\nbody\tO\nmovement\tO\nand\tO\nhearing\tO\nwere\tO\nexamined\tO\nfor\tO\n6\tO\nand\tO\nup\tO\nto\tO\n17\tO\nweeks\tO\n,\tO\nrespectively\tO\n.\tO\n\nAbnormal\tB-Disease\nmovements\tI-Disease\nand\tO\ndeafness\tB-Disease\noccurred\tO\nonly\tO\nin\tO\nrats\tO\ntreated\tO\nduring\tO\nthe\tO\npreweaning\tO\nperiod\tO\n;\tO\nwithin\tO\nthis\tO\nperiod\tO\nthe\tO\ngreatest\tO\nsensitivities\tO\nfor\tO\nthese\tO\nabnormalities\tO\noccurred\tO\nfrom\tO\n2\tO\nto\tO\n11\tO\n-\tO\n17\tO\nand\tO\n5\tO\nto\tO\n11\tO\ndays\tO\nof\tO\nage\tO\n,\tO\nrespectively\tO\n,\tO\nindicating\tO\nthat\tO\nthe\tO\ncochlea\tO\nis\tO\nmore\tO\nsensitive\tO\nto\tO\nstreptomycin\tB-Chemical\nthan\tO\nthe\tO\nsite\tO\n(\tO\nvestibular\tO\nor\tO\ncentral\tO\n)\tO\nresponsible\tO\nfor\tO\nthe\tO\ndyskinesias\tB-Disease\n.\tO\n\nLate\tO\n,\tO\nlate\tO\ndoxorubicin\tB-Chemical\ncardiotoxicity\tB-Disease\n.\tO\n\nCardiac\tB-Disease\ntoxicity\tI-Disease\nis\tO\na\tO\nmajor\tO\ncomplication\tO\nwhich\tO\nlimits\tO\nthe\tO\nuse\tO\nof\tO\nadriamycin\tB-Chemical\nas\tO\na\tO\nchemotherapeutic\tO\nagent\tO\n.\tO\n\nCardiomyopathy\tB-Disease\nis\tO\nfrequent\tO\nwhen\tO\nthe\tO\ntotal\tO\ndose\tO\nexceeds\tO\n600\tO\nmg\tO\n/\tO\nm2\tO\nand\tO\noccurs\tO\nwithin\tO\none\tO\nto\tO\nsix\tO\nmonths\tO\nafter\tO\ncessation\tO\nof\tO\ntherapy\tO\n.\tO\n\nA\tO\npatient\tO\nis\tO\nreported\tO\nwho\tO\ndeveloped\tO\nprogressive\tO\ncardiomyopathy\tB-Disease\ntwo\tO\nand\tO\none\tO\n-\tO\nhalf\tO\nyears\tO\nafter\tO\nreceiving\tO\n580\tO\nmg\tO\n/\tO\nm2\tO\nwhich\tO\napparently\tO\nrepresents\tO\nlate\tO\n,\tO\nlate\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nAttenuation\tO\nof\tO\nthe\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\ndiabetes\tB-Disease\n-\tI-Disease\ninsipidus\tI-Disease\n-\tI-Disease\nlike\tI-Disease\nsyndrome\tI-Disease\nby\tO\namiloride\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\namiloride\tB-Chemical\non\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\npolydipsia\tB-Disease\nand\tO\npolyuria\tB-Disease\nand\tO\non\tO\nthe\tO\nlithium\tB-Chemical\nconcentration\tO\nin\tO\nthe\tO\nplasma\tO\n,\tO\nbrain\tO\n,\tO\nkidney\tO\n,\tO\nthyroid\tO\nand\tO\nred\tO\nblood\tO\ncells\tO\nwas\tO\ninvestigated\tO\nin\tO\nrats\tO\n,\tO\nchronically\tO\ntreated\tO\nwith\tO\nLiCl\tB-Chemical\n.\tO\n\nAmiloride\tB-Chemical\nreduced\tO\nthe\tO\ndrinking\tO\nand\tO\nurine\tO\nvolume\tO\nof\tO\nrats\tO\nin\tO\nan\tO\nacute\tO\n(\tO\n6\tO\nor\tO\n12\tO\nh\tO\n)\tO\nand\tO\na\tO\nsubacute\tO\n(\tO\n3\tO\ndays\tO\n)\tO\nexperiment\tO\n.\tO\n\n6\tO\nh\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\namiloride\tB-Chemical\n,\tO\na\tO\nreduction\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\nlithium\tB-Chemical\ncontent\tO\nof\tO\nthe\tO\nrenal\tO\nmedulla\tO\nbut\tO\nnot\tO\nin\tO\nthe\tO\nother\tO\norgans\tO\nstudied\tO\n.\tO\n\nAt\tO\n12\tO\nh\tO\n,\tO\nall\tO\nthe\tO\ntissues\tO\nshowed\tO\na\tO\nslight\tO\nincrease\tO\nin\tO\nlithium\tB-Chemical\nlevels\tO\n.\tO\n\nAfter\tO\n3\tO\ndays\tO\nof\tO\ncombined\tO\ntreatment\tO\n,\tO\na\tO\nmarked\tO\nelevation\tO\nin\tO\nplasma\tO\nand\tO\ntissue\tO\nlithium\tB-Chemical\nlevels\tO\naccompanied\tO\na\tO\nreduction\tO\nin\tO\nwater\tO\nintake\tO\n.\tO\n\nIn\tO\nall\tO\nthe\tO\nexperiments\tO\n,\tO\nthe\tO\nattenuation\tO\nof\tO\nthe\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\ndiabetes\tB-Disease\n-\tI-Disease\ninsipidus\tI-Disease\n-\tI-Disease\nlike\tI-Disease\nsyndrome\tI-Disease\nby\tO\namiloride\tB-Chemical\nwas\tO\naccompanied\tO\nby\tO\na\tO\nreduction\tO\nof\tO\nthe\tO\nratio\tO\nbetween\tO\nthe\tO\nlithium\tB-Chemical\nconcentration\tO\nin\tO\nthe\tO\nrenal\tO\nmedulla\tO\nand\tO\nits\tO\nlevels\tO\nin\tO\nthe\tO\nblood\tO\nand\tO\nan\tO\nelevation\tO\nin\tO\nthe\tO\nplasma\tO\npotassium\tB-Chemical\nlevel\tO\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nacute\tO\namiloride\tB-Chemical\nadministration\tO\nto\tO\nlithium\tB-Chemical\n-\tO\ntreated\tO\npatients\tO\nsuffering\tO\nfrom\tO\npolydipsia\tB-Disease\nand\tO\npolyuria\tB-Disease\nmight\tO\nrelieve\tO\nthese\tO\npatients\tO\nbut\tO\nprolonged\tO\namiloride\tB-Chemical\nsupplementation\tO\nwould\tO\nresult\tO\nin\tO\nelevated\tO\nlithium\tB-Chemical\nlevels\tO\nand\tO\nmight\tO\nbe\tO\nhazardous\tO\n.\tO\n\nCardiovascular\tB-Disease\ncomplications\tI-Disease\nassociated\tO\nwith\tO\nterbutaline\tB-Chemical\ntreatment\tO\nfor\tO\npreterm\tB-Disease\nlabor\tI-Disease\n.\tO\n\nSevere\tO\ncardiovascular\tB-Disease\ncomplications\tI-Disease\noccurred\tO\nin\tO\neight\tO\nof\tO\n160\tO\npatients\tO\ntreated\tO\nwith\tO\nterbutaline\tB-Chemical\nfor\tO\npreterm\tB-Disease\nlabor\tI-Disease\n.\tO\n\nAssociated\tO\ncorticosteroid\tO\ntherapy\tO\nand\tO\ntwin\tO\ngestations\tO\nappear\tO\nto\tO\nbe\tO\npredisposing\tO\nfactors\tO\n.\tO\n\nPotential\tO\nmechanisms\tO\nof\tO\nthe\tO\npathophysiology\tO\nare\tO\nbriefly\tO\ndiscussed\tO\n.\tO\n\nToxic\tB-Disease\nhepatitis\tI-Disease\ninduced\tO\nby\tO\nantithyroid\tO\ndrugs\tO\n:\tO\nfour\tO\ncases\tO\nincluding\tO\none\tO\nwith\tO\ncross\tO\n-\tO\nreactivity\tO\nbetween\tO\ncarbimazole\tB-Chemical\nand\tO\nbenzylthiouracil\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThis\tO\nstudy\tO\nwas\tO\nconducted\tO\nto\tO\nassess\tO\nthe\tO\noccurrence\tO\nof\tO\nhepatic\tB-Disease\nadverse\tI-Disease\neffects\tI-Disease\nencountered\tO\nwith\tO\nantithyroid\tO\ndrugs\tO\n.\tO\n\nMETHODS\tO\n:\tO\nRetrospective\tO\nreview\tO\nof\tO\nmedical\tO\nrecords\tO\nof\tO\n236\tO\npatients\tO\nwith\tO\nhyperthyroidism\tB-Disease\nadmitted\tO\nin\tO\nour\tO\ndepartment\tO\n(\tO\nin\tO\n-\tO\nor\tO\nout\tO\n-\tO\npatients\tO\n)\tO\nfrom\tO\n1986\tO\nto\tO\n1992\tO\n.\tO\n\nRESULTS\tO\n:\tO\nFour\tO\npatients\tO\n(\tO\n1\tO\n.\tO\n7\tO\n%\tO\n)\tO\nwere\tO\nidentified\tO\nwith\tO\ntoxic\tB-Disease\nhepatitis\tI-Disease\nwhich\tO\ncould\tO\nreasonably\tO\nbe\tO\nattributed\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\nantithyroid\tO\nagent\tO\n.\tO\n\nTwo\tO\npatients\tO\nhad\tO\na\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\ninduced\tO\nby\tO\ncarbimazole\tB-Chemical\n(\tO\nN\tB-Chemical\nomercazole\tI-Chemical\n)\tO\n.\tO\n\nTwo\tO\nothers\tO\nhad\tO\na\tO\nmixed\tO\n(\tO\ncholestatic\tB-Disease\nand\tO\ncytolytic\tO\n)\tO\nhepatitis\tB-Disease\nfollowing\tO\ncarbimazole\tB-Chemical\n.\tO\n\nOne\tO\nof\tO\nthe\tO\nlatter\tO\ntwo\tO\npatients\tO\nfurther\tO\nexperienced\tO\na\tO\ncytolytic\tO\nhepatitis\tB-Disease\nwhich\tO\nappeared\tO\nafter\tO\nBenzylthiouracil\tB-Chemical\n(\tO\nBasd\tB-Chemical\nne\tI-Chemical\n)\tO\nhad\tO\nreplaced\tO\ncarbimazole\tB-Chemical\n.\tO\n\nBiological\tO\nfeatures\tO\nof\tO\nhepatitis\tB-Disease\ndisappeared\tO\nin\tO\nall\tO\ncases\tO\nafter\tO\ncessation\tO\nof\tO\nthe\tO\nincriminated\tO\ndrug\tO\n,\tO\nwhile\tO\nbiliary\tO\n,\tO\nviral\tO\nand\tO\nimmunological\tO\nsearches\tO\nwere\tO\nnegative\tO\n.\tO\n\nOnly\tO\n2\tO\npatients\tO\nof\tO\nour\tO\nretrospective\tO\nstudy\tO\nexperienced\tO\na\tO\nmild\tO\nor\tO\nsevere\tO\nneutropenia\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nToxic\tB-Disease\nhepatitis\tI-Disease\nis\tO\na\tO\npotential\tO\nadverse\tO\neffect\tO\nof\tO\nantithyroid\tO\ndrugs\tO\nwhich\tO\nwarrants\tO\n,\tO\nas\tO\nfor\tO\nhaematological\tO\ndisturbances\tO\n,\tO\na\tO\npre\tO\n-\tO\ntherapeutic\tO\ndetermination\tO\nand\tO\na\tO\ncareful\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\nrelevant\tO\nbiological\tO\nmarkers\tO\n.\tO\n\nMoreover\tO\n,\tO\nhepatotoxicity\tB-Disease\nmay\tO\nnot\tO\nbe\tO\nrestricted\tO\nto\tO\none\tO\nclass\tO\nof\tO\nantithyroid\tO\nagents\tO\n.\tO\n\nInteractive\tO\neffects\tO\nof\tO\nvariations\tO\nin\tO\n[\tO\nNa\tB-Chemical\n]\tO\no\tO\nand\tO\n[\tO\nCa\tB-Chemical\n]\tO\no\tO\non\tO\nrat\tO\natrial\tO\nspontaneous\tO\nfrequency\tO\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nvarying\tO\nthe\tO\nextracellular\tO\nconcentrations\tO\nof\tO\nNa\tB-Chemical\nand\tO\nCa\tB-Chemical\n(\tO\n[\tO\nNa\tB-Chemical\n]\tO\no\tO\nand\tO\n[\tO\nCa\tB-Chemical\n]\tO\no\tO\n)\tO\non\tO\nboth\tO\n,\tO\nthe\tO\nspontaneous\tO\nbeating\tO\nand\tO\nthe\tO\nnegative\tO\nchronotropic\tO\naction\tO\nof\tO\nverapamil\tB-Chemical\n,\tO\nwere\tO\nstudied\tO\nin\tO\nthe\tO\nisolated\tO\nrat\tO\natria\tO\n.\tO\n\nBasal\tO\nfrequency\tO\n(\tO\nBF\tO\n)\tO\nevaluated\tO\nby\tO\nsurface\tO\nelectrogram\tO\nwas\tO\n223\tO\n+\tO\n/\tO\n-\tO\n4\tO\nbeats\tO\n/\tO\nmin\tO\n.\tO\nin\tO\ncontrol\tO\nKrebs\tO\n-\tO\nRinger\tO\ncontaining\tO\n137\tO\nmM\tO\nNa\tB-Chemical\nand\tO\n1\tO\n.\tO\n35\tO\nmM\tO\nCa\tB-Chemical\n(\tO\nN\tO\n)\tO\n.\tO\n\nIt\tO\ndecreased\tO\nby\tO\n16\tO\n+\tO\n/\tO\n-\tO\n3\tO\n%\tO\nby\tO\nlowering\tO\n[\tO\nNa\tB-Chemical\n]\tO\no\tO\nto\tO\n78\tO\nmM\tO\n(\tO\nLNa\tO\n)\tO\n,\tO\n23\tO\n+\tO\n/\tO\n-\tO\n2\tO\n%\tO\nby\tO\nlowering\tO\nsimultaneously\tO\n[\tO\nNa\tB-Chemical\n]\tO\no\tO\nto\tO\n78\tO\nmM\tO\nand\tO\n[\tO\nCa\tB-Chemical\n]\tO\no\tO\nto\tO\n0\tO\n.\tO\n675\tO\nmM\tO\n(\tO\nLNa\tO\n+\tO\nLCa\tO\n)\tO\nand\tO\n31\tO\n+\tO\n/\tO\n-\tO\n5\tO\n%\tO\nby\tO\nlowering\tO\n[\tO\nNa\tB-Chemical\n]\tO\no\tO\nto\tO\n78\tO\nmM\tO\nplus\tO\nincreasing\tO\n[\tO\nCa\tB-Chemical\n]\tO\no\tO\nto\tO\n3\tO\n.\tO\n6\tO\nmM\tO\n(\tO\nLNa\tO\n+\tO\nHCa\tO\n)\tO\n.\tO\n\nAt\tO\nnormal\tO\n[\tO\nNa\tB-Chemical\n]\tO\no\tO\n,\tO\ndecrease\tO\n(\tO\n0\tO\n.\tO\n675\tO\nmM\tO\n)\tO\nor\tO\nincrease\tO\n(\tO\n3\tO\n.\tO\n6\tO\nmM\tO\n)\tO\nof\tO\n[\tO\nCa\tB-Chemical\n]\tO\no\tO\ndid\tO\nnot\tO\nmodify\tO\nBF\tO\n;\tO\na\tO\nreduction\tO\nof\tO\nten\tO\ntimes\tO\n(\tO\n0\tO\n.\tO\n135\tO\nmM\tO\nof\tO\nnormal\tO\n[\tO\nCa\tB-Chemical\n]\tO\no\tO\nwas\tO\neffective\tO\nto\tO\nreduce\tO\nBF\tO\nby\tO\n40\tO\n+\tO\n/\tO\n-\tO\n13\tO\n%\tO\n.\tO\n\nAll\tO\nnegative\tO\nchronotropic\tO\neffects\tO\nwere\tO\nBF\tO\n-\tO\ndependent\tO\n.\tO\n\nDose\tO\n-\tO\ndependent\tO\nbradycardia\tB-Disease\ninduced\tO\nby\tO\nverapamil\tB-Chemical\nwas\tO\npotentiated\tO\nby\tO\nLNa\tO\n,\tO\nLCa\tO\n,\tO\nand\tO\nHCa\tO\n.\tO\n\nIndependent\tO\nbut\tO\nnot\tO\nadditive\tO\neffects\tO\nof\tO\nNa\tB-Chemical\nand\tO\nCa\tB-Chemical\nare\tO\nshown\tO\nby\tO\ndecreases\tO\nin\tO\nthe\tO\nvalues\tO\nof\tO\n[\tO\nverapamil\tB-Chemical\n]\tO\no\tO\nneeded\tO\nto\tO\nreduce\tO\nBF\tO\nby\tO\n30\tO\n%\tO\n(\tO\nIC30\tO\n)\tO\nwith\tO\nthe\tO\nfollowing\tO\norder\tO\nof\tO\ninhibitory\tO\npotency\tO\n:\tO\nLNa\tO\n>\tO\nLCa\tO\n>\tO\nHCa\tO\n>\tO\nN\tO\n,\tO\nresulting\tO\nLNa\tO\n+\tO\nHCa\tO\nsimilar\tO\nto\tO\nLNa\tO\n.\tO\n\nThe\tO\n[\tO\nverapamil\tB-Chemical\n]\tO\no\tO\nthat\tO\narrested\tO\natrial\tO\nbeating\tO\n(\tO\nAC\tO\n)\tO\nwas\tO\nalso\tO\npotentiated\tO\nwith\tO\nthe\tO\norder\tO\nLNa\tO\n=\tO\nLNa\tO\n+\tO\nLCa\tO\n=\tO\nLNa\tO\n+\tO\nHCa\tO\n=\tO\nLCa\tO\n>\tO\nHCa\tO\n=\tO\nN\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nrat\tO\natrial\tO\nspontaneous\tO\nbeating\tO\nis\tO\nmore\tO\ndependent\tO\non\tO\n[\tO\nNa\tB-Chemical\n]\tO\no\tO\nthan\tO\non\tO\n[\tO\nCa\tB-Chemical\n]\tO\no\tO\nin\tO\na\tO\nrange\tO\nof\tO\n+\tO\n/\tO\n-\tO\n50\tO\n%\tO\nof\tO\ntheir\tO\nnormal\tO\nconcentration\tO\n.\tO\n\nAlso\tO\nthe\tO\nenhancement\tO\nof\tO\nverapamil\tB-Chemical\neffects\tO\non\tO\natrial\tO\nbeating\tO\nwas\tO\nmore\tO\npronounced\tO\nat\tO\nLNa\tO\nthan\tO\nat\tO\nLCa\tO\n.\tO\n(\tO\nABSTRACT\tO\nTRUNCATED\tO\nAT\tO\n250\tO\nWORDS\tO\n)\tO\n\nPseudo\tO\n-\tO\nallergic\tB-Disease\nreactions\tI-Disease\nto\tO\ncorticosteroids\tB-Chemical\n:\tO\ndiagnosis\tO\nand\tO\nalternatives\tO\n.\tO\n\nTwo\tO\npatients\tO\ntreated\tO\nwith\tO\nparenteral\tO\nparamethasone\tB-Chemical\n(\tO\nTriniol\tO\n)\tO\nand\tO\ndexamethasone\tB-Chemical\n(\tO\nSedionbel\tO\n)\tO\nare\tO\ndescribed\tO\n.\tO\n\nA\tO\nfew\tO\nminutes\tO\nafter\tO\nadministration\tO\nof\tO\nthe\tO\ndrugs\tO\n,\tO\nthey\tO\npresented\tO\nurticaria\tB-Disease\n(\tO\npatients\tO\n1\tO\nand\tO\n2\tO\n)\tO\nand\tO\nconjunctivitis\tB-Disease\n(\tO\npatient\tO\n1\tO\n)\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nour\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\ncause\tO\nof\tO\nthe\tO\npatients\tO\n'\tO\nreactions\tO\n,\tO\nthe\tO\nimmunological\tO\nmechanisms\tO\ninvolved\tO\nand\tO\nwhether\tO\nthese\tO\npatients\tO\nwould\tO\nbe\tO\nable\tO\nto\tO\ntolerate\tO\nany\tO\nkind\tO\nof\tO\ncorticoid\tO\n.\tO\n\nClinical\tO\nexaminations\tO\nand\tO\nskin\tO\n,\tO\noral\tO\nand\tO\nparenteral\tO\nchallenges\tO\nwith\tO\ndifferent\tO\ncorticosteroids\tB-Chemical\nand\tO\nELISA\tO\ntests\tO\nwere\tO\nperformed\tO\n.\tO\n\nIn\tO\nthe\tO\ntwo\tO\npatients\tO\n,\tO\nskin\tO\nand\tO\nELISA\tO\ntests\tO\nwith\tO\nparamethasone\tB-Chemical\nwere\tO\nnegative\tO\n,\tO\nas\tO\nwas\tO\nthe\tO\nprick\tO\ntest\tO\nwith\tO\neach\tO\nof\tO\nits\tO\nexcipients\tO\n.\tO\n\nA\tO\nsingle\tO\n-\tO\nblind\tO\nparenteral\tO\nchallenge\tO\nwith\tO\nTriniol\tO\nwas\tO\npositive\tO\nin\tO\nboth\tO\npatients\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\n1\tO\nml\tO\nof\tO\nthe\tO\ndrug\tO\n,\tO\nand\tO\nnegative\tO\nwith\tO\nits\tO\nexcipients\tO\n.\tO\n\nWe\tO\nalso\tO\ncarried\tO\nout\tO\noral\tO\nand\tO\nparenteral\tO\nchallenges\tO\nwith\tO\nother\tO\ncorticosteroids\tB-Chemical\nand\tO\nfound\tO\nintolerance\tO\nto\tO\nsome\tO\nof\tO\nthem\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nparamethasone\tB-Chemical\ncaused\tO\npseudoallergic\tO\nreactions\tO\nin\tO\nour\tO\npatients\tO\n.\tO\n\nCorticosteroids\tO\ndifferent\tO\nfrom\tO\nparamethasone\tB-Chemical\nalso\tO\nproduced\tO\nhypersensitivity\tB-Disease\nreactions\tO\nin\tO\nthese\tO\npatients\tO\n;\tO\nhowever\tO\n,\tO\na\tO\nfew\tO\nof\tO\nthem\tO\nwere\tO\ntolerated\tO\n.\tO\n\nThe\tO\nbasic\tO\nmechanisms\tO\nof\tO\nthose\tO\nreactions\tO\nare\tO\nnot\tO\nyet\tO\nfully\tO\nunderstood\tO\n.\tO\n\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\nreport\tO\nof\tO\na\tO\npseudo\tO\n-\tO\nallergy\tB-Disease\ncaused\tO\nby\tO\nparamethasone\tB-Chemical\n.\tO\n\nStudy\tO\nof\tO\nthe\tO\nrole\tO\nof\tO\nvitamin\tB-Chemical\nB12\tI-Chemical\nand\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\nsupplementation\tO\nin\tO\npreventing\tO\nhematologic\tO\ntoxicity\tB-Disease\nof\tO\nzidovudine\tB-Chemical\n.\tO\n\nA\tO\nprospective\tO\n,\tO\nrandomized\tO\nstudy\tO\nwas\tO\nconducted\tO\nto\tO\nevaluate\tO\nthe\tO\nrole\tO\nof\tO\nvitamin\tB-Chemical\nB12\tI-Chemical\nand\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\nsupplementation\tO\nin\tO\npreventing\tO\nzidovudine\tB-Chemical\n(\tO\nZDV\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nbone\tB-Disease\nmarrow\tI-Disease\nsuppression\tI-Disease\n.\tO\n\nSeventy\tO\n-\tO\nfive\tO\nhuman\tB-Disease\nimmunodeficiency\tI-Disease\nvirus\tI-Disease\n(\tI-Disease\nHIV\tI-Disease\n)\tI-Disease\n-\tI-Disease\ninfected\tI-Disease\npatients\tO\nwith\tO\nCD4\tO\n+\tO\ncell\tO\ncounts\tO\n<\tO\n500\tO\n/\tO\nmm3\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\neither\tO\nZDV\tB-Chemical\n(\tO\n500\tO\nmg\tO\ndaily\tO\n)\tO\nalone\tO\n(\tO\ngroup\tO\nI\tO\n,\tO\nn\tO\n=\tO\n38\tO\n)\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\n(\tO\n15\tO\nmg\tO\ndaily\tO\n)\tO\nand\tO\nintramascular\tO\nvitamin\tB-Chemical\nB12\tI-Chemical\n(\tO\n1000\tO\nmicrograms\tO\nmonthly\tO\n)\tO\n(\tO\ngroup\tO\nII\tO\n,\tO\nn\tO\n=\tO\n37\tO\n)\tO\n.\tO\n\nFinally\tO\n,\tO\n15\tO\npatients\tO\nwere\tO\nexcluded\tO\nfrom\tO\nthe\tO\nstudy\tO\n(\tO\nnoncompliance\tO\n14\tO\n,\tO\ndeath\tB-Disease\n1\tO\n)\tO\n;\tO\nthus\tO\n,\tO\n60\tO\npatients\tO\n(\tO\n31\tO\nin\tO\ngroup\tO\nI\tO\nand\tO\n29\tO\nin\tO\ngroup\tO\nII\tO\n)\tO\nwere\tO\neligible\tO\nfor\tO\nanalysis\tO\n.\tO\n\nNo\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\ngroups\tO\nwere\tO\nfound\tO\nat\tO\nenrollment\tO\n.\tO\n\nDuring\tO\nthe\tO\nstudy\tO\n,\tO\nvitamin\tB-Chemical\nB12\tI-Chemical\nand\tO\nfolate\tB-Chemical\nlevels\tO\nwere\tO\nsignificantly\tO\nhigher\tO\nin\tO\ngroup\tO\nII\tO\npatients\tO\n;\tO\nhowever\tO\n,\tO\nno\tO\ndifferences\tO\nin\tO\nhemoglobin\tO\n,\tO\nhematocrit\tO\n,\tO\nmean\tO\ncorpuscular\tO\nvolume\tO\n,\tO\nand\tO\nwhite\tO\n-\tO\ncell\tO\n,\tO\nneutrophil\tO\nand\tO\nplatelet\tO\ncounts\tO\nwere\tO\nobserved\tO\nbetween\tO\ngroups\tO\nat\tO\n3\tO\n,\tO\n6\tO\n,\tO\n9\tO\nand\tO\n12\tO\nmonths\tO\n.\tO\n\nSevere\tO\nhematologic\tO\ntoxicity\tB-Disease\n(\tO\nneutrophil\tO\ncount\tO\n<\tO\n1000\tO\n/\tO\nmm3\tO\nand\tO\n/\tO\nor\tO\nhemoglobin\tO\n<\tO\n8\tO\ng\tO\n/\tO\ndl\tO\n)\tO\noccurred\tO\nin\tO\n4\tO\npatients\tO\nassigned\tO\nto\tO\ngroup\tO\nI\tO\nand\tO\n7\tO\nassigned\tO\nto\tO\ngroup\tO\nII\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\ncorrelation\tO\nbetween\tO\nvitamin\tB-Chemical\nB12\tI-Chemical\nor\tO\nfolate\tB-Chemical\nlevels\tO\nand\tO\ndevelopment\tO\nof\tO\nmyelosuppression\tB-Disease\n.\tO\n\nVitamin\tB-Chemical\nB12\tI-Chemical\nand\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\nsupplementation\tO\nof\tO\nZDV\tB-Chemical\ntherapy\tO\ndoes\tO\nnot\tO\nseem\tO\nuseful\tO\nin\tO\npreventing\tO\nor\tO\nreducing\tO\nZDV\tB-Chemical\n-\tO\ninduced\tO\nmyelotoxicity\tB-Disease\nin\tO\nthe\tO\noverall\tO\ntreated\tO\npopulation\tO\n,\tO\nalthough\tO\na\tO\nbeneficial\tO\neffect\tO\nin\tO\ncertain\tO\nsubgroups\tO\nof\tO\npatients\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nSafety\tO\nand\tO\nside\tO\n-\tO\neffects\tO\nof\tO\nalprazolam\tB-Chemical\n.\tO\n\nControlled\tO\nstudy\tO\nin\tO\nagoraphobia\tB-Disease\nwith\tO\npanic\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nwidespread\tO\nuse\tO\nof\tO\nbenzodiazepines\tB-Chemical\nhas\tO\nled\tO\nto\tO\nincreasing\tO\nrecognition\tO\nof\tO\ntheir\tO\nunwanted\tO\neffects\tO\n.\tO\n\nThe\tO\nefficacy\tO\nof\tO\nalprazolam\tB-Chemical\nand\tO\nplacebo\tO\nin\tO\npanic\tB-Disease\ndisorder\tI-Disease\nwith\tO\nagoraphobia\tB-Disease\n,\tO\nand\tO\nthe\tO\nside\tO\n-\tO\neffect\tO\nand\tO\nadverse\tO\neffect\tO\nprofiles\tO\nof\tO\nboth\tO\ndrug\tO\ngroups\tO\nwere\tO\nmeasured\tO\n.\tO\n\nMETHOD\tO\n:\tO\nIn\tO\nLondon\tO\nand\tO\nToronto\tO\n154\tO\npatients\tO\nwho\tO\nmet\tO\nDSM\tO\n-\tO\nIII\tO\ncriteria\tO\nfor\tO\npanic\tB-Disease\ndisorder\tI-Disease\nwith\tO\nagoraphobia\tB-Disease\nwere\tO\nrandomised\tO\nto\tO\nalprazolam\tB-Chemical\nor\tO\nplacebo\tO\n.\tO\n\nSubjects\tO\nin\tO\neach\tO\ndrug\tO\ngroup\tO\nalso\tO\nreceived\tO\neither\tO\nexposure\tO\nor\tO\nrelaxation\tO\n.\tO\n\nTreatment\tO\nwas\tO\nfrom\tO\nweeks\tO\n0\tO\nto\tO\n8\tO\nand\tO\nwas\tO\nthen\tO\ntapered\tO\nfrom\tO\nweeks\tO\n8\tO\nto\tO\n16\tO\n.\tO\n\nRESULTS\tO\n:\tO\nMean\tO\nalprazolam\tB-Chemical\ndose\tO\nwas\tO\n5\tO\nmg\tO\ndaily\tO\n.\tO\n\nCompared\tO\nwith\tO\nplacebo\tO\nsubjects\tO\n,\tO\nalprazolam\tB-Chemical\npatients\tO\ndeveloped\tO\nmore\tO\nadverse\tO\nreactions\tO\n(\tO\n21\tO\n%\tO\nv\tO\n.\tO\n0\tO\n%\tO\n)\tO\nof\tO\ndepression\tB-Disease\n,\tO\nenuresis\tB-Disease\n,\tO\ndisinhibition\tO\nand\tO\naggression\tB-Disease\n;\tO\nand\tO\nmore\tO\nside\tO\n-\tO\neffects\tO\n,\tO\nparticularly\tO\nsedation\tO\n,\tO\nirritability\tB-Disease\n,\tO\nimpaired\tB-Disease\nmemory\tI-Disease\n,\tO\nweight\tB-Disease\nloss\tI-Disease\nand\tO\nataxia\tB-Disease\n.\tO\n\nSide\tO\n-\tO\neffects\tO\ntended\tO\nto\tO\ndiminish\tO\nduring\tO\ntreatment\tO\nbut\tO\nremained\tO\nsignificant\tO\nat\tO\nweek\tO\n8\tO\n.\tO\n\nDespite\tO\nthis\tO\n,\tO\nthe\tO\ndrop\tO\n-\tO\nout\tO\nrate\tO\nwas\tO\nlow\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAlprazolam\tB-Chemical\ncaused\tO\nside\tO\n-\tO\neffects\tO\nand\tO\nadverse\tO\neffects\tO\nduring\tO\ntreatment\tO\nbut\tO\nmany\tO\npatients\tO\nwere\tO\nwilling\tO\nto\tO\naccept\tO\nthese\tO\n.\tO\n\nCrescentic\tO\nfibrillary\tO\nglomerulonephritis\tB-Disease\nassociated\tO\nwith\tO\nintermittent\tO\nrifampin\tB-Chemical\ntherapy\tO\nfor\tO\npulmonary\tB-Disease\ntuberculosis\tI-Disease\n.\tO\n\nThis\tO\ncase\tO\nstudy\tO\nreveals\tO\nan\tO\nunusual\tO\nfinding\tO\nof\tO\nrapidly\tO\nproliferative\tO\ncrescentic\tO\nglomerulonephritis\tB-Disease\nin\tO\na\tO\npatient\tO\ntreated\tO\nwith\tO\nrifampin\tB-Chemical\nwho\tO\nhad\tO\nno\tO\nother\tO\nidentifiable\tO\ncauses\tO\nfor\tO\ndeveloping\tO\nthis\tO\ndisease\tO\n.\tO\n\nThis\tO\npatient\tO\nunderwent\tO\na\tO\n10\tO\n-\tO\nmonth\tO\nregimen\tO\nof\tO\nrifampin\tB-Chemical\nand\tO\nisoniazid\tB-Chemical\nfor\tO\npulmonary\tB-Disease\ntuberculosis\tI-Disease\nand\tO\nwas\tO\ndiscovered\tO\nto\tO\nhave\tO\ndeveloped\tO\nsigns\tO\nof\tO\nsevere\tO\nrenal\tB-Disease\nfailure\tI-Disease\nfive\tO\nweeks\tO\nafter\tO\ncompletion\tO\nof\tO\ntherapy\tO\n.\tO\n\nRenal\tO\nbiopsy\tO\nrevealed\tO\nsevere\tO\nglomerulonephritis\tB-Disease\nwith\tO\ncrescents\tO\n,\tO\nelectron\tO\ndense\tO\nfibrillar\tO\ndeposits\tO\nand\tO\nmoderate\tO\nlymphocytic\tO\ninterstitial\tO\ninfiltrate\tO\n.\tO\n\nOther\tO\npossible\tO\ncauses\tO\nof\tO\nrapidly\tO\nprogressive\tO\nglomerulonephritis\tB-Disease\nwere\tO\ninvestigated\tO\nand\tO\nruled\tO\nout\tO\n.\tO\n\nThis\tO\nreport\tO\ndocuments\tO\nthe\tO\nunusual\tO\noccurrence\tO\nof\tO\nrapidly\tO\nprogressive\tO\nglomerulonephritis\tB-Disease\nwith\tO\ncrescents\tO\nand\tO\nfibrillar\tO\nglomerulonephritis\tB-Disease\nin\tO\na\tO\npatient\tO\ntreated\tO\nwith\tO\nrifampin\tB-Chemical\n.\tO\n\nAcute\tO\nconfusion\tB-Disease\ninduced\tO\nby\tO\na\tO\nhigh\tO\n-\tO\ndose\tO\ninfusion\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\nand\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nA\tO\n61\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwas\tO\ntreated\tO\nwith\tO\ncombination\tO\nchemotherapy\tO\nincorporating\tO\ncisplatinum\tB-Chemical\n,\tO\netoposide\tB-Chemical\n,\tO\nhigh\tO\n-\tO\ndose\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n2\tO\n,\tO\n250\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\n24\tO\nhours\tO\n)\tO\nand\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\nfor\tO\nan\tO\ninoperable\tO\ngastric\tB-Disease\nadenocarcinoma\tI-Disease\n.\tO\n\nHe\tO\ndeveloped\tO\nacute\tO\nneurologic\tO\nsymptoms\tO\nof\tO\nmental\tO\nconfusion\tB-Disease\n,\tO\ndisorientation\tB-Disease\nand\tO\nirritability\tB-Disease\n,\tO\nand\tO\nthen\tO\nlapsed\tO\ninto\tO\na\tO\ndeep\tO\ncoma\tB-Disease\n,\tO\nlasting\tO\nfor\tO\napproximately\tO\n40\tO\nhours\tO\nduring\tO\nthe\tO\nfirst\tO\ndose\tO\n(\tO\nday\tO\n2\tO\n)\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\nand\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\ninfusion\tO\n.\tO\n\nThis\tO\ncomplication\tO\nreappeared\tO\non\tO\nday\tO\n25\tO\nduring\tO\nthe\tO\nsecond\tO\ndose\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\nand\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\n,\tO\nwhich\tO\nwere\tO\nthen\tO\nthe\tO\nonly\tO\ndrugs\tO\ngiven\tO\n.\tO\n\nBecause\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\nwas\tO\nunlikely\tO\nto\tO\nbe\tO\nassociated\tO\nwith\tO\nthis\tO\ncondition\tO\n,\tO\nneurotoxicity\tB-Disease\ndue\tO\nto\tO\nhigh\tO\n-\tO\ndose\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\nwas\tO\nhighly\tO\nsuspected\tO\n.\tO\n\nThe\tO\npathogenesis\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\nneurotoxicity\tB-Disease\nmay\tO\nbe\tO\ndue\tO\nto\tO\na\tO\nKrebs\tO\ncycle\tO\nblockade\tO\nby\tO\nfluoroacetate\tB-Chemical\nand\tO\nfluorocitrate\tB-Chemical\n,\tO\nthiamine\tB-Chemical\ndeficiency\tO\n,\tO\nor\tO\ndihydrouracil\tB-Chemical\ndehydrogenase\tO\ndeficiency\tO\n.\tO\n\nHigh\tO\n-\tO\ndose\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n/\tO\nfolinic\tB-Chemical\nacid\tI-Chemical\ninfusion\tO\ntherapy\tO\nhas\tO\nrecently\tO\nbecome\tO\na\tO\npopular\tO\nregimen\tO\nfor\tO\nvarious\tO\ncancers\tB-Disease\n.\tO\n\nIt\tO\nis\tO\nnecessary\tO\nthat\tO\nboth\tO\noncologists\tO\nand\tO\nneurologists\tO\nbe\tO\nfully\tO\naware\tO\nof\tO\nthis\tO\nunusual\tO\ncomplication\tO\n.\tO\n\nEffect\tO\nof\tO\nswitching\tO\ncarbamazepine\tB-Chemical\nto\tO\noxcarbazepine\tB-Chemical\non\tO\nthe\tO\nplasma\tO\nlevels\tO\nof\tO\nneuroleptics\tO\n.\tO\n\nA\tO\ncase\tO\nreport\tO\n.\tO\n\nCarbamazepine\tB-Chemical\nwas\tO\nswitched\tO\nto\tO\nits\tO\n10\tO\n-\tO\nketo\tO\nanalogue\tO\noxcarbazepine\tB-Chemical\namong\tO\nsix\tO\ndifficult\tO\n-\tO\nto\tO\n-\tO\ntreat\tO\nschizophrenic\tB-Disease\nor\tO\norganic\tB-Disease\npsychotic\tI-Disease\npatients\tO\nusing\tO\nconcomitantly\tO\nhaloperidol\tB-Chemical\n,\tO\nchlorpromazine\tB-Chemical\nor\tO\nclozapine\tB-Chemical\n.\tO\n\nThis\tO\nchange\tO\nresulted\tO\nwithin\tO\n2\tO\n-\tO\n4\tO\nweeks\tO\nin\tO\nthe\tO\n50\tO\n-\tO\n200\tO\n%\tO\nincrease\tO\nin\tO\nthe\tO\nplasma\tO\nlevels\tO\nof\tO\nthese\tO\nneuroleptics\tO\nand\tO\nthe\tO\nappearance\tO\nof\tO\nextrapyramidal\tB-Disease\nsymptoms\tI-Disease\n.\tO\n\nNone\tO\nof\tO\nthe\tO\npatients\tO\nshowed\tO\nany\tO\nclinical\tO\ndeteriotation\tO\nduring\tO\nthe\tO\nfollowing\tO\n3\tO\n-\tO\n6\tO\nmonths\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthis\tO\ncase\tO\nreport\tO\nsupport\tO\nthe\tO\nidea\tO\nthat\tO\nin\tO\ncontrast\tO\nwith\tO\ncarbamazepine\tB-Chemical\noxcarbazepine\tB-Chemical\ndoes\tO\nnot\tO\ninduce\tO\nthe\tO\nhepatic\tO\nmicrosomal\tO\nenzyme\tO\nsystems\tO\nregulating\tO\nthe\tO\ninactivation\tO\nof\tO\nantipsychotic\tO\ndrugs\tO\n.\tO\n\nTime\tO\ncourse\tO\nof\tO\nlipid\tO\nperoxidation\tO\nin\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n.\tO\n\nReactive\tO\noxygen\tB-Chemical\nspecies\tO\nhave\tO\nbeen\tO\nimplicated\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nacute\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nnephropathy\tB-Disease\n,\tO\nwith\tO\nantioxidants\tO\nsignificantly\tO\nreducing\tO\nthe\tO\nproteinuria\tB-Disease\n.\tO\n\nThe\tO\ntemporal\tO\nrelationship\tO\nbetween\tO\nlipid\tO\nperoxidation\tO\nin\tO\nthe\tO\nkidney\tO\nand\tO\nproteinuria\tB-Disease\nwas\tO\nexamined\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nRats\tO\nwere\tO\ntreated\tO\nwith\tO\na\tO\nsingle\tO\nIV\tO\ninjection\tO\nof\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n,\tO\n(\tO\nPAN\tB-Chemical\n,\tO\n7\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\n24\tO\nhour\tO\nurine\tO\nsamples\tO\nwere\tO\nobtained\tO\nprior\tO\nto\tO\nsacrifice\tO\non\tO\ndays\tO\n3\tO\n,\tO\n5\tO\n,\tO\n7\tO\n,\tO\n10\tO\n,\tO\n17\tO\n,\tO\n27\tO\n,\tO\n41\tO\n(\tO\nN\tO\n=\tO\n5\tO\n-\tO\n10\tO\nper\tO\ngroup\tO\n)\tO\n.\tO\n\nThe\tO\nkidneys\tO\nwere\tO\nremoved\tO\n,\tO\nflushed\tO\nwith\tO\nice\tO\ncold\tO\nTRIS\tO\nbuffer\tO\n.\tO\n\nKidney\tO\ncortices\tO\nfrom\tO\neach\tO\nanimal\tO\nwere\tO\nused\tO\nto\tO\nprepare\tO\nhomogenates\tO\n.\tO\n\nTissue\tO\nlipid\tO\nperoxidation\tO\nwas\tO\nmeasured\tO\nin\tO\nwhole\tO\nhomogenates\tO\nas\tO\nwell\tO\nas\tO\nin\tO\nlipid\tO\nextracts\tO\nfrom\tO\nhomogenates\tO\nas\tO\nthiobarbituric\tB-Chemical\nacid\tI-Chemical\nreactive\tO\nsubstances\tO\n.\tO\n\nProteinuria\tB-Disease\nwas\tO\nevident\tO\nat\tO\nday\tO\n5\tO\n,\tO\npeaked\tO\nat\tO\nday\tO\n7\tO\nand\tO\npersisted\tO\nto\tO\nday\tO\n27\tO\n.\tO\n\nLipid\tO\nperoxidation\tO\nin\tO\nhomogenates\tO\nwas\tO\nmaximal\tO\nat\tO\nday\tO\n3\tO\nand\tO\ndeclined\tO\nrapidly\tO\nto\tO\ncontrol\tO\nlevels\tO\nby\tO\nday\tO\n17\tO\n.\tO\n\nThis\tO\nstudy\tO\nsupports\tO\nthe\tO\nrole\tO\nof\tO\nlipid\tO\nperoxidation\tO\nin\tO\nmediating\tO\nthe\tO\nproteinuric\tB-Disease\ninjury\tI-Disease\nin\tO\nPAN\tB-Chemical\nnephropathy\tB-Disease\n.\tO\n\nComposition\tO\nof\tO\ngall\tB-Disease\nbladder\tI-Disease\nstones\tI-Disease\nassociated\tO\nwith\tO\noctreotide\tB-Chemical\n:\tO\nresponse\tO\nto\tO\noral\tO\nursodeoxycholic\tB-Chemical\nacid\tI-Chemical\n.\tO\n\nOctreotide\tB-Chemical\n,\tO\nan\tO\neffective\tO\ntreatment\tO\nfor\tO\nacromegaly\tB-Disease\n,\tO\ninduces\tO\ngall\tB-Disease\nbladder\tI-Disease\nstones\tI-Disease\nin\tO\n13\tO\n-\tO\n60\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nBecause\tO\nknowledge\tO\nof\tO\nstone\tO\ncomposition\tO\nis\tO\nessential\tO\nfor\tO\nstudies\tO\nof\tO\ntheir\tO\npathogenesis\tO\n,\tO\ntreatment\tO\n,\tO\nand\tO\nprevention\tO\n,\tO\nthis\tO\nwas\tO\ninvestigated\tO\nby\tO\ndirect\tO\nand\tO\nindirect\tO\nmethods\tO\nin\tO\n14\tO\noctreotide\tB-Chemical\ntreated\tO\nacromegalic\tB-Disease\npatients\tO\nwith\tO\ngall\tB-Disease\nstones\tI-Disease\n.\tO\n\nChemical\tO\nanalysis\tO\nof\tO\ngall\tB-Disease\nstones\tI-Disease\nretrieved\tO\nat\tO\ncholecystectomy\tO\nfrom\tO\ntwo\tO\npatients\tO\n,\tO\nshowed\tO\nthat\tO\nthey\tO\ncontained\tO\n71\tO\n%\tO\nand\tO\n87\tO\n%\tO\ncholesterol\tB-Chemical\nby\tO\nweight\tO\n.\tO\n\nIn\tO\nthe\tO\nremaining\tO\n12\tO\npatients\tO\n,\tO\nlocalised\tO\ncomputed\tO\ntomography\tO\nof\tO\nthe\tO\ngall\tO\nbladder\tO\nshowed\tO\nthat\tO\neight\tO\nhad\tO\nstones\tO\nwith\tO\nmaximum\tO\nattenuation\tO\nscores\tO\nof\tO\n<\tO\n100\tO\nHounsfield\tO\nunits\tO\n(\tO\nvalues\tO\nof\tO\n<\tO\n100\tO\nHU\tO\npredict\tO\ncholesterol\tB-Chemical\nrich\tO\n,\tO\ndissolvable\tO\nstones\tO\n)\tO\n.\tO\n\nGall\tO\nbladder\tO\nbile\tO\nwas\tO\nobtained\tO\nby\tO\nultrasound\tO\nguided\tO\n,\tO\nfine\tO\nneedle\tO\npuncture\tO\nfrom\tO\nsix\tO\npatients\tO\n.\tO\n\nAll\tO\nsix\tO\npatients\tO\nhad\tO\nsupersaturated\tO\nbile\tO\n(\tO\nmean\tO\n(\tO\nSEM\tO\n)\tO\ncholesterol\tB-Chemical\nsaturation\tO\nindex\tO\nof\tO\n1\tO\n.\tO\n19\tO\n(\tO\n0\tO\n.\tO\n08\tO\n)\tO\n(\tO\nrange\tO\n1\tO\n.\tO\n01\tO\n-\tO\n1\tO\n.\tO\n53\tO\n)\tO\n)\tO\nand\tO\nall\tO\nhad\tO\nabnormally\tO\nrapid\tO\ncholesterol\tB-Chemical\nmicrocrystal\tO\nnucleation\tO\ntimes\tO\n(\tO\n<\tO\n4\tO\ndays\tO\n(\tO\nrange\tO\n1\tO\n-\tO\n4\tO\n)\tO\n)\tO\n,\tO\nwhilst\tO\nin\tO\nfour\tO\n,\tO\nthe\tO\nbile\tO\ncontained\tO\ncholesterol\tB-Chemical\nmicrocrystals\tO\nimmediately\tO\nafter\tO\nsampling\tO\n.\tO\n\nOf\tO\nthe\tO\n12\tO\npatients\tO\nconsidered\tO\nfor\tO\noral\tO\nursodeoxycholic\tB-Chemical\nacid\tI-Chemical\n(\tO\nUDCA\tB-Chemical\n)\tO\ntreatment\tO\n,\tO\ntwo\tO\nhad\tO\na\tO\nblocked\tO\ncystic\tO\nduct\tO\nand\tO\nwere\tO\nnot\tO\nstarted\tO\non\tO\nUDCA\tB-Chemical\nwhile\tO\none\tO\nwas\tO\nlost\tO\nto\tO\nfollow\tO\nup\tO\n.\tO\n\nAfter\tO\none\tO\nyear\tO\nof\tO\ntreatment\tO\n,\tO\nfive\tO\nof\tO\nthe\tO\nremaining\tO\nnine\tO\npatients\tO\nshowed\tO\neither\tO\npartial\tO\n(\tO\nn\tO\n=\tO\n3\tO\n)\tO\nor\tO\ncomplete\tO\n(\tO\nn\tO\n=\tO\n2\tO\n)\tO\ngall\tB-Disease\nstone\tI-Disease\ndissolution\tO\n,\tO\nsuggesting\tO\nthat\tO\ntheir\tO\nstones\tO\nwere\tO\ncholesterol\tB-Chemical\nrich\tO\n.\tO\n\nThis\tO\ncorresponds\tO\n,\tO\nby\tO\nactuarial\tO\n(\tO\nlife\tO\ntable\tO\n)\tO\nanalysis\tO\n,\tO\nto\tO\na\tO\ncombined\tO\ngall\tB-Disease\nstone\tI-Disease\ndissolution\tO\nrate\tO\nof\tO\n58\tO\n.\tO\n3\tO\n(\tO\n15\tO\n.\tO\n9\tO\n%\tO\n)\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\noctreotide\tB-Chemical\ninduced\tO\ngall\tB-Disease\nstones\tI-Disease\nare\tO\ngenerally\tO\nsmall\tO\n,\tO\nmultiple\tO\n,\tO\nand\tO\ncholesterol\tB-Chemical\nrich\tO\nalthough\tO\n,\tO\nin\tO\ncommon\tO\nwith\tO\nspontaneous\tO\ngall\tB-Disease\nstone\tI-Disease\ndisease\tI-Disease\n,\tO\nat\tO\npresentation\tO\nsome\tO\npatients\tO\nwill\tO\nhave\tO\na\tO\nblocked\tO\ncystic\tO\nduct\tO\nand\tO\nsome\tO\ngall\tB-Disease\nstones\tI-Disease\ncontaining\tO\ncalcium\tB-Chemical\n.\tO\n\nErythema\tB-Disease\nmultiforme\tI-Disease\nand\tO\nhypersensitivity\tB-Disease\nmyocarditis\tI-Disease\ncaused\tO\nby\tO\nampicillin\tB-Chemical\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nerythema\tB-Disease\nmultiforme\tI-Disease\nand\tO\nhypersensitivity\tB-Disease\nmyocarditis\tI-Disease\ncaused\tO\nby\tO\nampicillin\tB-Chemical\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n13\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwas\tO\ntreated\tO\nwith\tO\nampicillin\tB-Chemical\nand\tO\ngentamicin\tB-Chemical\nbecause\tO\nof\tO\nsuspected\tO\nsepticemia\tB-Disease\n.\tO\n\nMedications\tO\nwere\tO\ndiscontinued\tO\nwhen\tO\nerythema\tB-Disease\nmultiforme\tI-Disease\nand\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\ncaused\tO\nby\tO\nmyocarditis\tB-Disease\noccurred\tO\n.\tO\n\nThe\tO\npatient\tO\nwas\tO\ntreated\tO\nwith\tO\nmethylprednisolone\tB-Chemical\nand\tO\ngradually\tO\nimproved\tO\n.\tO\n\nMacrophage\tO\n-\tO\nmigration\tO\ninhibition\tO\n(\tO\nMIF\tO\n)\tO\ntest\tO\nwith\tO\nampicillin\tB-Chemical\nwas\tO\npositive\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nAfter\tO\nmost\tO\ninfections\tB-Disease\ncausing\tO\nerythema\tB-Disease\nmultiforme\tI-Disease\nand\tO\nmyocarditis\tB-Disease\nwere\tO\nruled\tO\nout\tO\n,\tO\na\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nallergic\tI-Disease\nreaction\tI-Disease\nwas\tO\nsuspected\tO\n.\tO\n\nPositive\tO\nMIF\tO\ntest\tO\nfor\tO\nampicillin\tB-Chemical\nshowed\tO\nsensitization\tO\nof\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nlymphocytes\tO\nto\tO\nampicillin\tB-Chemical\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nHypersensitivity\tB-Disease\nmyocarditis\tI-Disease\nis\tO\na\tO\nrare\tO\nand\tO\ndangerous\tO\nmanifestation\tO\nof\tO\nallergy\tB-Disease\nto\tO\npenicillins\tB-Chemical\n.\tO\n\nClomipramine\tB-Chemical\n-\tO\ninduced\tO\nsleep\tB-Disease\ndisturbance\tI-Disease\ndoes\tO\nnot\tO\nimpair\tO\nits\tO\nprolactin\tO\n-\tO\nreleasing\tO\naction\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\nexamine\tO\nthe\tO\nrole\tO\nof\tO\nsleep\tB-Disease\ndisturbance\tI-Disease\n,\tO\ninduced\tO\nby\tO\nclomipramine\tB-Chemical\nadministration\tO\n,\tO\non\tO\nthe\tO\nsecretory\tO\nrate\tO\nof\tO\nprolactin\tO\n(\tO\nPRL\tO\n)\tO\nin\tO\naddition\tO\nto\tO\nthe\tO\ndirect\tO\ndrug\tO\neffect\tO\n.\tO\n\nTwo\tO\ngroups\tO\nof\tO\nsupine\tO\nsubjects\tO\nwere\tO\nstudied\tO\nunder\tO\nplacebo\tO\n-\tO\ncontrolled\tO\nconditions\tO\n,\tO\none\tO\nduring\tO\nthe\tO\nnight\tO\n,\tO\nwhen\tO\nsleeping\tO\n(\tO\nn\tO\n=\tO\n7\tO\n)\tO\nand\tO\nthe\tO\nother\tO\nat\tO\ndaytime\tO\n,\tO\nwhen\tO\nawake\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\n.\tO\n\nEach\tO\nsubject\tO\nreceived\tO\na\tO\nsingle\tO\n50\tO\nmg\tO\ndose\tO\nof\tO\nclomipramine\tB-Chemical\ngiven\tO\norally\tO\n2\tO\nhours\tO\nbefore\tO\nblood\tO\ncollection\tO\n.\tO\n\nPlasma\tO\nPRL\tO\nconcentrations\tO\nwere\tO\nanalysed\tO\nat\tO\n10\tO\nmin\tO\nintervals\tO\nand\tO\nunderlying\tO\nsecretory\tO\nrates\tO\ncalculated\tO\nby\tO\na\tO\ndeconvolution\tO\nprocedure\tO\n.\tO\n\nFor\tO\nboth\tO\nexperiments\tO\nthe\tO\ndrug\tO\nintake\tO\nled\tO\nto\tO\nsignificant\tO\nincreases\tO\nin\tO\nPRL\tO\nsecretion\tO\n,\tO\nacting\tO\npreferentially\tO\non\tO\ntonic\tO\nsecretion\tO\nas\tO\npulse\tO\namplitude\tO\nand\tO\nfrequency\tO\ndid\tO\nnot\tO\ndiffer\tO\nsignificantly\tO\nfrom\tO\ncorresponding\tO\ncontrol\tO\nvalues\tO\n.\tO\n\nDuring\tO\nthe\tO\nnight\tO\nclomipramine\tB-Chemical\ningestion\tO\naltered\tO\nthe\tO\ncomplete\tO\nsleep\tO\narchitecture\tO\nin\tO\nthat\tO\nit\tO\nsuppressed\tO\nREM\tO\nsleep\tO\nand\tO\nthe\tO\nsleep\tO\ncycles\tO\nand\tO\ninduced\tO\nincreased\tO\nwakefulness\tO\n.\tO\n\nAs\tO\nthe\tO\nrelative\tO\nincrease\tO\nin\tO\nPRL\tO\nsecretion\tO\nexpressed\tO\nas\tO\na\tO\npercentage\tO\nof\tO\nthe\tO\nmean\tO\ndid\tO\nnot\tO\nsignificantly\tO\ndiffer\tO\nbetween\tO\nthe\tO\nnight\tO\nand\tO\nday\tO\ntime\tO\nstudies\tO\n(\tO\n46\tO\n+\tO\n/\tO\n-\tO\n19\tO\n%\tO\nvs\tO\n34\tO\n+\tO\n/\tO\n-\tO\n10\tO\n%\tO\n)\tO\n,\tO\nit\tO\ncan\tO\nbe\tO\nconcluded\tO\nthat\tO\nthe\tO\nobserved\tO\nsleep\tB-Disease\ndisturbance\tI-Disease\ndid\tO\nnot\tO\ninterfere\tO\nwith\tO\nthe\tO\ndrug\tO\naction\tO\nper\tO\nse\tO\n.\tO\n\nThe\tO\npresence\tO\nof\tO\nREM\tO\nsleep\tO\nwas\tO\nshown\tO\nnot\tO\nto\tO\nbe\tO\na\tO\ndetermining\tO\nfactor\tO\neither\tO\nfor\tO\nsecretory\tO\npulse\tO\namplitude\tO\nand\tO\nfrequency\tO\n,\tO\nas\tO\n,\tO\nfor\tO\nboth\tO\n,\tO\nmean\tO\nnocturnal\tO\nvalues\tO\nwere\tO\nsimilar\tO\nwith\tO\nand\tO\nwithout\tO\nprior\tO\nclomipramine\tB-Chemical\ningestion\tO\n.\tO\n\nSurvey\tO\nof\tO\ncomplications\tO\nof\tO\nindocyanine\tB-Chemical\ngreen\tI-Chemical\nangiography\tO\nin\tO\nJapan\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nWe\tO\nevaluated\tO\nthe\tO\nsafety\tO\nof\tO\nindocyanine\tB-Chemical\ngreen\tI-Chemical\nfor\tO\nuse\tO\nin\tO\nfundus\tO\nangiography\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nsent\tO\na\tO\nquestionnaire\tO\nconcerning\tO\ncomplications\tO\nof\tO\nindocyanine\tB-Chemical\ngreen\tI-Chemical\nto\tO\n32\tO\ninstitutions\tO\nin\tO\nJapan\tO\n,\tO\nwhich\tO\nwere\tO\nselected\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\nthe\tO\nclient\tO\nlist\tO\nfrom\tO\nthe\tO\nTopcon\tO\nCompany\tO\n,\tO\nwhich\tO\nmanufactures\tO\nthe\tO\nindocyanine\tB-Chemical\ngreen\tI-Chemical\nfundus\tO\ncamera\tO\n.\tO\n\nRESULTS\tO\n:\tO\nOphthalmologists\tO\nat\tO\n15\tO\ninstitutions\tO\nresponded\tO\n,\tO\nreporting\tO\na\tO\ntotal\tO\nof\tO\n3\tO\n,\tO\n774\tO\nindocyanine\tB-Chemical\ngreen\tI-Chemical\nangiograms\tO\nperformed\tO\non\tO\n2\tO\n,\tO\n820\tO\npatients\tO\nbetween\tO\nJune\tO\n1984\tO\nand\tO\nSeptember\tO\n1992\tO\n.\tO\n\nBefore\tO\nangiography\tO\n,\tO\nintradermal\tO\nor\tO\nintravenous\tO\nindocyanine\tB-Chemical\ngreen\tI-Chemical\ntesting\tO\n,\tO\nor\tO\nboth\tO\nwas\tO\nperformed\tO\nat\tO\n13\tO\nof\tO\n15\tO\ninstitutions\tO\n.\tO\n\nFor\tO\nthree\tO\npatients\tO\n,\tO\nthe\tO\ndecision\tO\nwas\tO\nmade\tO\nnot\tO\nto\tO\nproceed\tO\nwith\tO\nangiography\tO\nafter\tO\npositive\tO\npreangiographic\tO\ntesting\tO\n.\tO\n\nThe\tO\ndosage\tO\nof\tO\nindocyanine\tB-Chemical\ngreen\tI-Chemical\nused\tO\nfor\tO\nangiography\tO\nvaried\tO\nfrom\tO\n25\tO\nto\tO\n75\tO\nmg\tO\n,\tO\ndepending\tO\nupon\tO\nthe\tO\ninstitution\tO\n.\tO\n\nThere\tO\nwere\tO\n13\tO\ncases\tO\nof\tO\nadverse\tO\nreactions\tO\n(\tO\n0\tO\n.\tO\n34\tO\n%\tO\n)\tO\n,\tO\nten\tO\nof\tO\nwhich\tO\nwere\tO\nmild\tO\nreactions\tO\nsuch\tO\nas\tO\nnausea\tB-Disease\n,\tO\nexanthema\tB-Disease\n,\tO\nurtication\tB-Disease\n,\tO\nitchiness\tB-Disease\n,\tO\nand\tO\nurgency\tO\nto\tO\ndefecate\tO\n,\tO\nand\tO\ndid\tO\nnot\tO\nrequire\tO\ntreatment\tO\n.\tO\n\nAlso\tO\nrecorded\tO\nwere\tO\none\tO\ncase\tO\nof\tO\npain\tB-Disease\nof\tO\nthe\tO\nvein\tO\n,\tO\nwhich\tO\nrequired\tO\ntreatment\tO\n,\tO\nand\tO\ntwo\tO\ncases\tO\nof\tO\nhypotension\tB-Disease\n.\tO\n\nThe\tO\ntwo\tO\nhypotensive\tB-Disease\npatients\tO\nrequired\tO\ntreatment\tO\nfor\tO\nshock\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nA\tO\ncomparison\tO\nof\tO\nfrequency\tO\nof\tO\nadverse\tO\nreactions\tO\nto\tO\nindocyanine\tB-Chemical\ngreen\tI-Chemical\nwith\tO\nthe\tO\npreviously\tO\nreported\tO\nfrequency\tO\nof\tO\nsuch\tO\nreactions\tO\nto\tO\nfluorescein\tB-Chemical\nsodium\tI-Chemical\nindicated\tO\nthat\tO\nindocyanine\tB-Chemical\ngreen\tI-Chemical\nis\tO\na\tO\nsafe\tO\nas\tO\nfluorescein\tB-Chemical\nfor\tO\nuse\tO\nin\tO\nangiography\tO\n.\tO\n\nAngioedema\tB-Disease\nfollowing\tO\nthe\tO\nintravenous\tO\nadministration\tO\nof\tO\nmetoprolol\tB-Chemical\n.\tO\n\nA\tO\n72\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwas\tO\nadmitted\tO\nto\tO\nthe\tO\nhospital\tO\nwith\tO\n\"\tO\nflash\tO\n\"\tO\npulmonary\tB-Disease\nedema\tI-Disease\n,\tO\npreceded\tO\nby\tO\nchest\tB-Disease\npain\tI-Disease\n,\tO\nrequiring\tO\nintubation\tO\n.\tO\n\nHer\tO\nmedical\tO\nhistory\tO\nincluded\tO\ncoronary\tB-Disease\nartery\tI-Disease\ndisease\tI-Disease\nwith\tO\nprevious\tO\nmyocardial\tB-Disease\ninfarctions\tI-Disease\n,\tO\nhypertension\tB-Disease\n,\tO\nand\tO\ndiabetes\tB-Disease\nmellitus\tI-Disease\n.\tO\n\nA\tO\nhistory\tO\nof\tO\nangioedema\tB-Disease\nsecondary\tO\nto\tO\nlisinopril\tB-Chemical\ntherapy\tO\nwas\tO\nelicited\tO\n.\tO\n\nCurrent\tO\nmedications\tO\ndid\tO\nnot\tO\ninclude\tO\nangiotensin\tB-Chemical\n-\tO\nconverting\tO\nenzyme\tO\ninhibitors\tO\nor\tO\nbeta\tO\n-\tO\nblockers\tO\n.\tO\n\nShe\tO\nhad\tO\nno\tO\nprevious\tO\nbeta\tO\n-\tO\nblocking\tO\ndrug\tO\nexposure\tO\n.\tO\n\nDuring\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\nhospitalization\tO\n(\tO\nwhile\tO\nintubated\tO\n)\tO\n,\tO\nintravenous\tO\nmetoprolol\tB-Chemical\nwas\tO\ngiven\tO\n,\tO\nresulting\tO\nin\tO\nsevere\tO\nangioedema\tB-Disease\n.\tO\n\nThe\tO\nangioedema\tB-Disease\nresolved\tO\nafter\tO\ntherapy\tO\nwith\tO\nintravenous\tO\nsteroids\tB-Chemical\nand\tO\ndiphenhydramine\tB-Chemical\nhydrochloride\tO\n.\tO\n\nEffect\tO\nof\tO\nconiine\tB-Chemical\non\tO\nthe\tO\ndeveloping\tO\nchick\tO\nembryo\tO\n.\tO\n\nConiine\tB-Chemical\n,\tO\nan\tO\nalkaloid\tO\nfrom\tO\nConium\tO\nmaculatum\tO\n(\tO\npoison\tO\nhemlock\tO\n)\tO\n,\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nbe\tO\nteratogenic\tO\nin\tO\nlivestock\tO\n.\tO\n\nThe\tO\nmajor\tO\nteratogenic\tO\noutcome\tO\nis\tO\narthrogryposis\tB-Disease\n,\tO\npresumably\tO\ndue\tO\nto\tO\nnicotinic\tO\nreceptor\tO\nblockade\tO\n.\tO\n\nHowever\tO\n,\tO\nconiine\tB-Chemical\nhas\tO\nfailed\tO\nto\tO\nproduce\tO\narthrogryposis\tB-Disease\nin\tO\nrats\tO\nor\tO\nmice\tO\nand\tO\nis\tO\nonly\tO\nweakly\tO\nteratogenic\tO\nin\tO\nrabbits\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nevaluate\tO\nand\tO\ncompare\tO\nthe\tO\neffects\tO\nof\tO\nconiine\tB-Chemical\nand\tO\nnicotine\tB-Chemical\nin\tO\nthe\tO\ndeveloping\tO\nchick\tO\n.\tO\n\nConcentrations\tO\nof\tO\nconiine\tB-Chemical\nand\tO\nnicotine\tB-Chemical\nsulfate\tO\nwere\tO\n0\tO\n.\tO\n015\tO\n%\tO\n,\tO\n0\tO\n.\tO\n03\tO\n%\tO\n,\tO\n0\tO\n.\tO\n075\tO\n%\tO\n,\tO\n0\tO\n.\tO\n15\tO\n%\tO\n,\tO\n0\tO\n.\tO\n75\tO\n%\tO\n,\tO\n1\tO\n.\tO\n5\tO\n%\tO\n,\tO\n3\tO\n%\tO\n,\tO\nand\tO\n6\tO\n%\tO\nand\tO\n1\tO\n%\tO\n,\tO\n5\tO\n%\tO\n,\tO\nand\tO\n10\tO\n%\tO\n,\tO\nrespectively\tO\n.\tO\n\nBoth\tO\ncompounds\tO\ncaused\tO\ndeformations\tB-Disease\nand\tO\nlethality\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nAll\tO\nconcentrations\tO\nof\tO\nnicotine\tB-Chemical\nsulfate\tO\ncaused\tO\nsome\tO\nlethality\tO\nbut\tO\na\tO\nno\tO\neffect\tO\nlevel\tO\nfor\tO\nconiine\tB-Chemical\nlethality\tO\nwas\tO\n0\tO\n.\tO\n75\tO\n%\tO\n.\tO\n\nThe\tO\ndeformations\tB-Disease\ncaused\tO\nby\tO\nboth\tO\nconiine\tB-Chemical\nand\tO\nnicotine\tB-Chemical\nsulfate\tO\nwere\tO\nexcessive\tB-Disease\nflexion\tI-Disease\nor\tI-Disease\nextension\tI-Disease\nof\tI-Disease\none\tI-Disease\nor\tI-Disease\nmore\tI-Disease\ntoes\tI-Disease\n.\tO\n\nNo\tO\nhistopathological\tO\nalterations\tO\nor\tO\ndifferences\tO\nin\tO\nbone\tO\nformation\tO\nwere\tO\nseen\tO\nin\tO\nthe\tO\nlimbs\tO\nor\tO\ntoes\tO\nof\tO\nany\tO\nchicks\tO\nfrom\tO\nany\tO\ngroup\tO\n;\tO\nhowever\tO\n,\tO\nextensive\tO\ncranial\tB-Disease\nhemorrhage\tI-Disease\noccurred\tO\nin\tO\nall\tO\nnicotine\tB-Chemical\nsulfate\tO\n-\tO\ntreated\tO\nchicks\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nstatistically\tO\nsignificant\tO\n(\tO\nP\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\ndecrease\tO\nin\tO\nmovement\tO\nin\tO\nconiine\tB-Chemical\nand\tO\nnicotine\tB-Chemical\nsulfate\tO\ntreated\tO\nchicks\tO\nas\tO\ndetermined\tO\nby\tO\nultrasound\tO\n.\tO\n\nControl\tO\nchicks\tO\nwere\tO\nin\tO\nmotion\tO\nan\tO\naverage\tO\nof\tO\n33\tO\n.\tO\n67\tO\n%\tO\nof\tO\nthe\tO\ntime\tO\n,\tO\nwhile\tO\nconiine\tB-Chemical\n-\tO\ntreated\tO\nchicks\tO\nwere\tO\nonly\tO\nmoving\tO\n8\tO\n.\tO\n95\tO\n%\tO\nof\tO\na\tO\n5\tO\n-\tO\nmin\tO\ninterval\tO\n,\tO\nand\tO\nno\tO\nmovement\tO\nwas\tO\nobserved\tO\nfor\tO\nnicotine\tB-Chemical\nsulfate\tO\ntreated\tO\nchicks\tO\n.\tO\n\nIn\tO\nsummary\tO\n,\tO\nthe\tO\nchick\tO\nembryo\tO\nprovides\tO\na\tO\nreliable\tO\nand\tO\nsimple\tO\nexperimental\tO\nanimal\tO\nmodel\tO\nof\tO\nconiine\tB-Chemical\n-\tO\ninduced\tO\narthrogryposis\tB-Disease\n.\tO\n\nData\tO\nfrom\tO\nthis\tO\nmodel\tO\nsupport\tO\na\tO\nmechanism\tO\ninvolving\tO\nnicotinic\tO\nreceptor\tO\nblockade\tO\nwith\tO\nsubsequent\tO\ndecreased\tO\nfetal\tO\nmovement\tO\n.\tO\n\nImmediate\tO\nallergic\tB-Disease\nreactions\tI-Disease\nto\tO\namoxicillin\tB-Chemical\n.\tO\n\nA\tO\nlarge\tO\ngroup\tO\nof\tO\npatients\tO\nwith\tO\nsuspected\tO\nallergic\tB-Disease\nreactions\tI-Disease\nto\tO\nbeta\tB-Chemical\n-\tI-Chemical\nlactam\tI-Chemical\nantibiotics\tO\nwas\tO\nevaluated\tO\n.\tO\n\nA\tO\ndetailed\tO\nclinical\tO\nhistory\tO\n,\tO\ntogether\tO\nwith\tO\nskin\tO\ntests\tO\n,\tO\nRAST\tO\n(\tO\nradioallergosorbent\tO\ntest\tO\n)\tO\n,\tO\nand\tO\ncontrolled\tO\nchallenge\tO\ntests\tO\n,\tO\nwas\tO\nused\tO\nto\tO\nestablish\tO\nwhether\tO\npatients\tO\nallergic\tB-Disease\nto\tO\nbeta\tB-Chemical\n-\tI-Chemical\nlactam\tI-Chemical\nantibiotics\tO\nhad\tO\nselective\tO\nimmediate\tO\nallergic\tB-Disease\nresponses\tO\nto\tO\namoxicillin\tB-Chemical\n(\tO\nAX\tB-Chemical\n)\tO\nor\tO\nwere\tO\ncross\tO\n-\tO\nreacting\tO\nwith\tO\nother\tO\npenicillin\tB-Chemical\nderivatives\tO\n.\tO\n\nSkin\tO\ntests\tO\nwere\tO\nperformed\tO\nwith\tO\nbenzylpenicilloyl\tB-Chemical\n-\tI-Chemical\npoly\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\nlysine\tI-Chemical\n(\tO\nBPO\tB-Chemical\n-\tI-Chemical\nPLL\tI-Chemical\n)\tO\n,\tO\nbenzylpenicilloate\tB-Chemical\n,\tO\nbenzylpenicillin\tB-Chemical\n(\tO\nPG\tB-Chemical\n)\tO\n,\tO\nampicillin\tB-Chemical\n(\tO\nAMP\tB-Chemical\n)\tO\n,\tO\nand\tO\nAX\tB-Chemical\n.\tO\n\nRAST\tO\nfor\tO\nBPO\tB-Chemical\n-\tI-Chemical\nPLL\tI-Chemical\nand\tO\nAX\tB-Chemical\n-\tO\nPLL\tO\nwas\tO\ndone\tO\n.\tO\n\nWhen\tO\nboth\tO\nskin\tO\ntest\tO\nand\tO\nRAST\tO\nfor\tO\nBPO\tB-Chemical\nwere\tO\nnegative\tO\n,\tO\nsingle\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\nchallenge\tO\ntests\tO\nwere\tO\ndone\tO\nto\tO\nensure\tO\ntolerance\tO\nof\tO\nPG\tB-Chemical\nor\tO\nsensitivity\tO\nto\tO\nAX\tB-Chemical\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n177\tO\npatients\tO\nwere\tO\ndiagnosed\tO\nas\tO\nallergic\tB-Disease\nto\tO\nbeta\tB-Chemical\n-\tI-Chemical\nlactam\tI-Chemical\nantibiotics\tO\n.\tO\n\nWe\tO\nselected\tO\nthe\tO\n54\tO\n(\tO\n30\tO\n.\tO\n5\tO\n%\tO\n)\tO\ncases\tO\nof\tO\nimmediate\tO\nAX\tB-Chemical\nallergy\tB-Disease\nwith\tO\ngood\tO\ntolerance\tO\nof\tO\nPG\tB-Chemical\n.\tO\n\nAnaphylaxis\tB-Disease\nwas\tO\nseen\tO\nin\tO\n37\tO\npatients\tO\n(\tO\n69\tO\n%\tO\n)\tO\n,\tO\nthe\tO\nother\tO\n17\tO\n(\tO\n31\tO\n%\tO\n)\tO\nhaving\tO\nurticaria\tB-Disease\nand\tO\n/\tO\nor\tO\nangioedema\tB-Disease\n.\tO\n\nAll\tO\nthe\tO\npatients\tO\nwere\tO\nskin\tO\ntest\tO\nnegative\tO\nto\tO\nBPO\tB-Chemical\n;\tO\n49\tO\nof\tO\n51\tO\n(\tO\n96\tO\n%\tO\n)\tO\nwere\tO\nalso\tO\nnegative\tO\nto\tO\nMDM\tB-Disease\n,\tO\nand\tO\n44\tO\nof\tO\n46\tO\n(\tO\n96\tO\n%\tO\n)\tO\nto\tO\nPG\tB-Chemical\n.\tO\n\nSkin\tO\ntests\tO\nwith\tO\nAX\tB-Chemical\nwere\tO\npositive\tO\nin\tO\n34\tO\n(\tO\n63\tO\n%\tO\n)\tO\npatients\tO\n.\tO\n\nRAST\tO\nwas\tO\npositive\tO\nfor\tO\nAX\tB-Chemical\nin\tO\n22\tO\npatients\tO\n(\tO\n41\tO\n%\tO\n)\tO\nand\tO\nto\tO\nBPO\tB-Chemical\nin\tO\njust\tO\n5\tO\n(\tO\n9\tO\n%\tO\n)\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\nsera\tO\nwith\tO\nnegative\tO\nRAST\tO\nfor\tO\nAX\tB-Chemical\nwere\tO\npositive\tO\nto\tO\nBPO\tB-Chemical\n.\tO\n\nChallenge\tO\ntests\tO\nwith\tO\nAX\tB-Chemical\nwere\tO\nperformed\tO\nin\tO\n23\tO\nsubjects\tO\n(\tO\n43\tO\n%\tO\n)\tO\nto\tO\nestablish\tO\nthe\tO\ndiagnosis\tO\nof\tO\nimmediate\tO\nallergic\tB-Disease\nreaction\tI-Disease\nto\tO\nAX\tB-Chemical\n,\tO\nand\tO\nin\tO\n15\tO\ncases\tO\n(\tO\n28\tO\n%\tO\n)\tO\nboth\tO\nskin\tO\ntest\tO\nand\tO\nRAST\tO\nfor\tO\nAX\tB-Chemical\nwere\tO\nnegative\tO\n.\tO\n\nPG\tB-Chemical\nwas\tO\nwell\tO\ntolerated\tO\nby\tO\nall\tO\n54\tO\npatients\tO\n.\tO\n\nWe\tO\ndescribe\tO\nthe\tO\nlargest\tO\ngroup\tO\nof\tO\nAX\tB-Chemical\n-\tO\nallergic\tB-Disease\npatients\tO\nwho\tO\nhave\tO\ntolerated\tO\nPG\tB-Chemical\nreported\tO\nso\tO\nfar\tO\n.\tO\n\nDiagnosis\tO\nof\tO\nthese\tO\npatients\tO\ncan\tO\nbe\tO\nachieved\tO\nonly\tO\nif\tO\nspecific\tO\nAX\tB-Chemical\n-\tO\nrelated\tO\nreagents\tO\nare\tO\nemployed\tO\n.\tO\n\nFurther\tO\nstudies\tO\nare\tO\nnecessary\tO\nto\tO\ndetermine\tO\nthe\tO\nexact\tO\nextent\tO\nof\tO\nthis\tO\nproblem\tO\nand\tO\nto\tO\nimprove\tO\nthe\tO\nefficacy\tO\nof\tO\ndiagnostic\tO\nmethods\tO\n.\tO\n\nReversal\tO\nby\tO\nphenylephrine\tB-Chemical\nof\tO\nthe\tO\nbeneficial\tO\neffects\tO\nof\tO\nintravenous\tO\nnitroglycerin\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nmyocardial\tI-Disease\ninfarction\tI-Disease\n.\tO\n\nNitroglycerin\tB-Chemical\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nreduce\tO\nST\tO\n-\tO\nsegment\tO\nelevation\tO\nduring\tO\nacute\tB-Disease\nmyocardial\tI-Disease\ninfarction\tI-Disease\n,\tO\nan\tO\neffect\tO\npotentiated\tO\nin\tO\nthe\tO\ndog\tO\nby\tO\nagents\tO\nthat\tO\nreverse\tO\nnitroglycerin\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nOur\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\ndetermine\tO\nthe\tO\neffects\tO\nof\tO\ncombined\tO\nnitroglycerin\tB-Chemical\nand\tO\nphenylephrine\tB-Chemical\ntherapy\tO\n.\tO\n\nTen\tO\npatients\tO\nwith\tO\nacute\tO\ntransmural\tO\nmyocardial\tB-Disease\ninfarctions\tI-Disease\nreceived\tO\nintravenous\tO\nnitroglycerin\tB-Chemical\n,\tO\nsufficient\tO\nto\tO\nreduce\tO\nmean\tO\narterial\tO\npressure\tO\nfrom\tO\n107\tO\n+\tO\n/\tO\n-\tO\n6\tO\nto\tO\n85\tO\n+\tO\n/\tO\n-\tO\n6\tO\nmm\tO\nHg\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nfor\tO\n60\tO\nminutes\tO\n.\tO\n\nLeft\tO\nventricular\tO\nfilling\tO\npressure\tO\ndecreased\tO\nfrom\tO\n19\tO\n+\tO\n/\tO\n-\tO\n2\tO\nto\tO\n11\tO\n+\tO\n/\tO\n-\tO\n2\tO\nmm\tO\nHg\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nSigmaST\tO\n,\tO\nthe\tO\nsum\tO\nof\tO\nST\tO\n-\tO\nsegment\tO\nelevations\tO\nin\tO\n16\tO\nprecordial\tO\nleads\tO\n,\tO\ndecreased\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n02\tO\n)\tO\nwith\tO\nintravenous\tO\nnitroglycerin\tB-Chemical\n.\tO\n\nSubsequent\tO\naddition\tO\nof\tO\nphenylephrine\tB-Chemical\ninfusion\tO\n,\tO\nsufficient\tO\nto\tO\nre\tO\n-\tO\nelevate\tO\nmean\tO\narterial\tO\npressure\tO\nto\tO\n106\tO\n+\tO\n/\tO\n-\tO\n4\tO\nmm\tO\nHg\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n001\tO\n)\tO\nfor\tO\n30\tO\nminutes\tO\n,\tO\nincreased\tO\nleft\tO\nventricular\tO\nfilling\tO\npressure\tO\nto\tO\n17\tO\n+\tO\n/\tO\n-\tO\n2\tO\nmm\tO\nHg\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\nand\tO\nalso\tO\nsignificantly\tO\nincreased\tO\nsigmaST\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nOur\tO\nresults\tO\nsuggest\tO\nthat\tO\naddition\tO\nof\tO\nphenylephrine\tB-Chemical\nto\tO\nnitroglycerin\tB-Chemical\nis\tO\nnot\tO\nbeneficial\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nmyocardial\tI-Disease\ninfarction\tI-Disease\n.\tO\n\nAcetazolamide\tB-Chemical\n-\tO\ninduced\tO\nnephrolithiasis\tB-Disease\n:\tO\nimplications\tO\nfor\tO\ntreatment\tO\nof\tO\nneuromuscular\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nCarbonic\tO\nanhydrase\tO\ninhibitors\tO\ncan\tO\ncause\tO\nnephrolithiasis\tB-Disease\n.\tO\n\nWe\tO\nstudied\tO\n20\tO\npatients\tO\nreceiving\tO\nlong\tO\n-\tO\nterm\tO\ncarbonic\tO\nanhydrase\tO\ninhibitor\tO\ntreatment\tO\nfor\tO\nperiodic\tO\nparalysis\tB-Disease\nand\tO\nmyotonia\tB-Disease\n.\tO\n\nThree\tO\npatients\tO\non\tO\nacetazolamide\tB-Chemical\n(\tO\n15\tO\n%\tO\n)\tO\ndeveloped\tO\nrenal\tB-Disease\ncalculi\tI-Disease\n.\tO\n\nExtracorporeal\tO\nlithotripsy\tO\nsuccessfully\tO\nremoved\tO\na\tO\nrenal\tB-Disease\ncalculus\tI-Disease\nin\tO\none\tO\npatient\tO\nand\tO\nsurgery\tO\nremoved\tO\na\tO\nstaghorn\tO\ncalculus\tB-Disease\nin\tO\nanother\tO\n,\tO\npermitting\tO\ncontinued\tO\ntreatment\tO\n.\tO\n\nRenal\tO\nfunction\tO\nremained\tO\nnormal\tO\nin\tO\nall\tO\npatients\tO\n.\tO\n\nNephrolithiasis\tB-Disease\nis\tO\na\tO\ncomplication\tO\nof\tO\nacetazolamide\tB-Chemical\nbut\tO\ndoes\tO\nnot\tO\npreclude\tO\nits\tO\nuse\tO\n.\tO\n\nEffects\tO\nof\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\non\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\ntoxicity\tB-Disease\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ninvestigate\tO\nthe\tO\ninfluence\tO\nof\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\non\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\ntoxicity\tB-Disease\n.\tO\n\nFor\tO\neach\tO\nof\tO\nthe\tO\nthree\tO\ntested\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\n(\tO\ndiltiazem\tB-Chemical\n,\tO\nverapamil\tB-Chemical\nand\tO\nbepridil\tB-Chemical\n)\tO\n6\tO\ngroups\tO\nof\tO\nmice\tO\nwere\tO\ntreated\tO\nby\tO\ntwo\tO\ndifferent\tO\ndoses\tO\n,\tO\ni\tO\n.\tO\ne\tO\n.\tO\n2\tO\nand\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\nor\tO\nan\tO\nequal\tO\nvolume\tO\nof\tO\nsaline\tO\nfor\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\nn\tO\n=\tO\n20\tO\n)\tO\n;\tO\n15\tO\nminutes\tO\nlater\tO\n,\tO\nall\tO\nthe\tO\nanimals\tO\nwere\tO\ninjected\tO\nwith\tO\na\tO\nsingle\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\ni\tO\n.\tO\np\tO\n.\tO\ndose\tO\nof\tO\nbupivacaine\tB-Chemical\n.\tO\n\nThe\tO\nconvulsant\tO\nactivity\tO\n,\tO\nthe\tO\ntime\tO\nof\tO\nlatency\tO\nto\tO\nconvulse\tO\nand\tO\nthe\tO\nmortality\tO\nrate\tO\nwere\tO\nassessed\tO\nin\tO\neach\tO\ngroup\tO\n.\tO\n\nThe\tO\nlocal\tO\nanesthetic\tO\n-\tO\ninduced\tO\nmortality\tO\nwas\tO\nsignificantly\tO\nincreased\tO\nby\tO\nthe\tO\nthree\tO\ndifferent\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\n.\tO\n\nThe\tO\nconvulsant\tO\nactivity\tO\nof\tO\nbupivacaine\tB-Chemical\nwas\tO\nnot\tO\nsignificantly\tO\nmodified\tO\nbut\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\ndecreased\tO\nthe\tO\ntime\tO\nof\tO\nlatency\tO\nto\tO\nobtain\tO\nbupivacaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n;\tO\nthis\tO\neffect\tO\nwas\tO\nless\tO\npronounced\tO\nwith\tO\nbepridil\tB-Chemical\n.\tO\n\nEpidural\tO\nblood\tO\nflow\tO\nduring\tO\nprostaglandin\tB-Chemical\nE1\tI-Chemical\nor\tO\ntrimethaphan\tB-Chemical\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nTo\tO\nevaluate\tO\nthe\tO\neffect\tO\nof\tO\nprostaglandin\tB-Chemical\nE1\tI-Chemical\n(\tO\nPGE1\tB-Chemical\n)\tO\nor\tO\ntrimethaphan\tB-Chemical\n(\tO\nTMP\tB-Chemical\n)\tO\ninduced\tO\nhypotension\tB-Disease\non\tO\nepidural\tO\nblood\tO\nflow\tO\n(\tO\nEBF\tO\n)\tO\nduring\tO\nspinal\tO\nsurgery\tO\n,\tO\nEBF\tO\nwas\tO\nmeasured\tO\nusing\tO\nthe\tO\nheat\tO\nclearance\tO\nmethod\tO\nin\tO\n30\tO\npatients\tO\nwho\tO\nunderwent\tO\npostero\tO\n-\tO\nlateral\tO\ninterbody\tO\nfusion\tO\nunder\tO\nisoflurane\tB-Chemical\nanaesthesia\tO\n.\tO\n\nAn\tO\ninitial\tO\ndose\tO\nof\tO\n0\tO\n.\tO\n1\tO\nmicrogram\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nmin\tO\n-\tO\n1\tO\nof\tO\nPGE1\tB-Chemical\n(\tO\n15\tO\npatients\tO\n)\tO\n,\tO\nor\tO\n10\tO\nmicrograms\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nmin\tO\n-\tO\n1\tO\nof\tO\nTMP\tB-Chemical\n(\tO\n15\tO\npatients\tO\n)\tO\nwas\tO\nadministered\tO\nintravenously\tO\nafter\tO\nthe\tO\ndural\tO\nopening\tO\nand\tO\nthe\tO\ndose\tO\nwas\tO\nadjusted\tO\nto\tO\nmaintain\tO\nthe\tO\nmean\tO\narterial\tO\nblood\tO\npressure\tO\n(\tO\nMAP\tO\n)\tO\nat\tO\nabout\tO\n60\tO\nmmHg\tO\n.\tO\n\nThe\tO\nhypotensive\tB-Disease\ndrug\tO\nwas\tO\ndiscontinued\tO\nat\tO\nthe\tO\ncompletion\tO\nof\tO\nthe\tO\noperative\tO\nprocedure\tO\n.\tO\n\nAfter\tO\nstarting\tO\nPGE1\tB-Chemical\nor\tO\nTMP\tB-Chemical\n,\tO\nMAP\tO\nand\tO\nrate\tO\npressure\tO\nproduct\tO\n(\tO\nRPP\tO\n)\tO\ndecreased\tO\nsignificantly\tO\ncompared\tO\nwith\tO\npreinfusion\tO\nvalues\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n01\tO\n)\tO\n,\tO\nand\tO\nthe\tO\ndegree\tO\nof\tO\nhypotension\tB-Disease\ndue\tO\nto\tO\nPGE1\tB-Chemical\nremained\tO\nconstant\tO\nuntil\tO\n60\tO\nmin\tO\nafter\tO\nits\tO\ndiscontinuation\tO\n.\tO\n\nHeart\tO\nrate\tO\n(\tO\nHR\tO\n)\tO\ndid\tO\nnot\tO\nchange\tO\nin\tO\neither\tO\ngroup\tO\n.\tO\n\nEBFF\tO\ndid\tO\nnot\tO\nchange\tO\nduring\tO\nPGE1\tB-Chemical\ninfusion\tO\nwhereas\tO\nin\tO\nthe\tO\nTMP\tB-Chemical\ngroup\tO\n,\tO\nEBF\tO\ndecreased\tO\nsignificantly\tO\nat\tO\n30\tO\nand\tO\n60\tO\nmin\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\nTMP\tB-Chemical\n(\tO\npreinfusion\tO\n:\tO\n45\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n13\tO\n.\tO\n9\tO\nml\tO\n/\tO\n100g\tO\n/\tO\nmin\tO\n.\tO\n30\tO\nmin\tO\n:\tO\n32\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n9\tO\n.\tO\n9\tO\nml\tO\n/\tO\n100\tO\ng\tO\n/\tO\nmin\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n60\tO\nmin\tO\n:\tO\n30\tO\n+\tO\n/\tO\n-\tO\n7\tO\n.\tO\n5\tO\nml\tO\n/\tO\n100\tO\ng\tO\n/\tO\nmin\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nPGE1\tB-Chemical\nmay\tO\nbe\tO\npreferable\tO\nto\tO\nTMP\tB-Chemical\nfor\tO\nhypotensive\tB-Disease\nanaesthesia\tO\nin\tO\nspinal\tO\nsurgery\tO\nbecause\tO\nTMP\tB-Chemical\ndecreased\tO\nEBF\tO\n.\tO\n\nDup\tB-Chemical\n753\tI-Chemical\nprevents\tO\nthe\tO\ndevelopment\tO\nof\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nnephrosis\tB-Disease\n.\tO\n\nThe\tO\nappearance\tO\nof\tO\nnephrotic\tB-Disease\nsyndromes\tI-Disease\nsuch\tO\nas\tO\nproteinuria\tB-Disease\n,\tO\nhypoalbuminemia\tB-Disease\n,\tO\nhypercholesterolemia\tB-Disease\nand\tO\nincrease\tO\nin\tO\nblood\tB-Chemical\nnitrogen\tI-Chemical\nurea\tI-Chemical\n,\tO\ninduced\tO\nin\tO\nrats\tO\nby\tO\ninjection\tO\nof\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nwas\tO\nmarkedly\tO\ninhibited\tO\nby\tO\noral\tO\nadministration\tO\nof\tO\nDup\tB-Chemical\n753\tI-Chemical\n(\tO\nlosartan\tB-Chemical\n)\tO\n,\tO\na\tO\nnovel\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\nantagonist\tO\n,\tO\nat\tO\na\tO\ndose\tO\nof\tO\n1\tO\nor\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nper\tO\nday\tO\n.\tO\n\nThe\tO\nresults\tO\nsuggest\tO\na\tO\npossible\tO\ninvolvement\tO\nof\tO\nthe\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nnephrosis\tB-Disease\n.\tO\n\nNeuroplasticity\tO\nof\tO\nthe\tO\nadult\tO\nprimate\tO\nauditory\tO\ncortex\tO\nfollowing\tO\ncochlear\tO\nhearing\tB-Disease\nloss\tI-Disease\n.\tO\n\nTonotopic\tO\norganization\tO\nis\tO\nan\tO\nessential\tO\nfeature\tO\nof\tO\nthe\tO\nprimary\tO\nauditory\tO\narea\tO\n(\tO\nA1\tO\n)\tO\nof\tO\nprimate\tO\ncortex\tO\n.\tO\n\nIn\tO\nA1\tO\nof\tO\nmacaque\tO\nmonkeys\tO\n,\tO\nlow\tO\nfrequencies\tO\nare\tO\nrepresented\tO\nrostrolaterally\tO\nand\tO\nhigh\tO\nfrequencies\tO\nare\tO\nrepresented\tO\ncaudomedially\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nif\tO\nchanges\tO\noccur\tO\nin\tO\nthis\tO\ntonotopic\tO\norganization\tO\nfollowing\tO\ncochlear\tO\nhearing\tB-Disease\nloss\tI-Disease\n.\tO\n\nUnder\tO\nanesthesia\tO\n,\tO\nthe\tO\nsuperior\tO\ntemporal\tO\ngyrus\tO\nof\tO\nadult\tO\nmacaque\tO\nmonkeys\tO\nwas\tO\nexposed\tO\n,\tO\nand\tO\nthe\tO\ntonotopic\tO\norganization\tO\nof\tO\nA1\tO\nwas\tO\nmapped\tO\nusing\tO\nconventional\tO\nmicroelectrode\tO\nrecording\tO\ntechniques\tO\n.\tO\n\nFollowing\tO\nrecovery\tO\n,\tO\nthe\tO\nmonkeys\tO\nwere\tO\nselectively\tO\ndeafened\tO\nfor\tO\nhigh\tO\nfrequencies\tO\nusing\tO\nkanamycin\tB-Chemical\nand\tO\nfurosemide\tB-Chemical\n.\tO\n\nThe\tO\nactual\tO\nfrequencies\tO\ndeafened\tO\nwere\tO\ndetermined\tO\nby\tO\nthe\tO\nloss\tO\nof\tO\ntone\tO\n-\tO\nburst\tO\nelicited\tO\nauditory\tO\nbrainstem\tO\nresponses\tO\n.\tO\n\nThree\tO\nmonths\tO\nafter\tO\ndeafening\tO\n,\tO\nA1\tO\nwas\tO\nremapped\tO\n.\tO\n\nPostmortem\tO\ncytoarchitectural\tO\nfeatures\tO\nidentifying\tO\nA1\tO\nwere\tO\ncorrelated\tO\nwith\tO\nthe\tO\nelectrophysiologic\tO\ndata\tO\n.\tO\n\nThe\tO\nresults\tO\nindicate\tO\nthat\tO\nthe\tO\ndeprived\tO\narea\tO\nof\tO\nA1\tO\nundergoes\tO\nextensive\tO\nreorganization\tO\nand\tO\nbecomes\tO\nresponsive\tO\nto\tO\nintact\tO\ncochlear\tO\nfrequencies\tO\n.\tO\n\nThe\tO\nregion\tO\nof\tO\ncortex\tO\nthat\tO\nrepresents\tO\nthe\tO\nlow\tO\nfrequencies\tO\nwas\tO\nnot\tO\nobviously\tO\naffected\tO\nby\tO\nthe\tO\ncochlear\tO\nhearing\tB-Disease\nloss\tI-Disease\n.\tO\n\nSodium\tB-Chemical\nbicarbonate\tI-Chemical\nalleviates\tO\npenile\tB-Disease\npain\tI-Disease\ninduced\tO\nby\tO\nintracavernous\tO\ninjections\tO\nfor\tO\nerectile\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nIn\tO\nan\tO\nattempt\tO\nto\tO\ndetermine\tO\nwhether\tO\npenile\tB-Disease\npain\tI-Disease\nassociated\tO\nwith\tO\nintracorporeal\tO\ninjections\tO\ncould\tO\nbe\tO\ndue\tO\nto\tO\nthe\tO\nacidity\tO\nof\tO\nthe\tO\nmedication\tO\n,\tO\nwe\tO\nperformed\tO\na\tO\nrandomized\tO\nstudy\tO\ncomparing\tO\nthe\tO\nincidence\tO\nof\tO\npenile\tB-Disease\npain\tI-Disease\nfollowing\tO\nintracorporeal\tO\ninjections\tO\nwith\tO\nor\tO\nwithout\tO\nthe\tO\naddition\tO\nof\tO\nsodium\tB-Chemical\nbicarbonate\tI-Chemical\nto\tO\nthe\tO\nintracorporeal\tO\nmedications\tO\n.\tO\n\nA\tO\ntotal\tO\nof\tO\n38\tO\nconsecutive\tO\npatients\tO\nwho\tO\npresented\tO\nto\tO\nour\tO\nclinic\tO\nwith\tO\nimpotence\tB-Disease\nreceived\tO\n0\tO\n.\tO\n2\tO\nml\tO\n.\tO\nof\tO\na\tO\ncombination\tO\nof\tO\n3\tO\ndrugs\tO\n:\tO\n6\tO\nmg\tO\n.\tO\npapaverine\tB-Chemical\n,\tO\n100\tO\nmicrograms\tO\n.\tO\nphentolamine\tB-Chemical\nand\tO\n10\tO\nmicrograms\tO\n.\tO\nprostaglandin\tB-Chemical\nE1\tI-Chemical\nwith\tO\n(\tO\npH\tO\n7\tO\n.\tO\n05\tO\n)\tO\nor\tO\nwithout\tO\n(\tO\npH\tO\n4\tO\n.\tO\n17\tO\n)\tO\nthe\tO\naddition\tO\nof\tO\nsodium\tB-Chemical\nbicarbonate\tI-Chemical\n(\tO\n0\tO\n.\tO\n03\tO\nmEq\tO\n.\tO\n)\tO\n.\tO\n\nOf\tO\nthe\tO\n19\tO\npatients\tO\nwithout\tO\nsodium\tB-Chemical\nbicarbonate\tI-Chemical\nadded\tO\nto\tO\nthe\tO\nmedication\tO\n11\tO\n(\tO\n58\tO\n%\tO\n)\tO\ncomplained\tO\nof\tO\npenile\tB-Disease\npain\tI-Disease\ndue\tO\nto\tO\nthe\tO\nmedication\tO\n,\tO\nwhile\tO\nonly\tO\n1\tO\nof\tO\nthe\tO\n19\tO\nmen\tO\n(\tO\n5\tO\n%\tO\n)\tO\nwho\tO\nreceived\tO\nsodium\tB-Chemical\nbicarbonate\tI-Chemical\ncomplained\tO\nof\tO\npenile\tB-Disease\npain\tI-Disease\n.\tO\n\nFrom\tO\nthese\tO\ndata\tO\nwe\tO\nconclude\tO\nthat\tO\nthe\tO\npenile\tB-Disease\npain\tI-Disease\nfollowing\tO\nintracorporeal\tO\ninjections\tO\nis\tO\nmost\tO\nlikely\tO\ndue\tO\nto\tO\nthe\tO\nacidity\tO\nof\tO\nthe\tO\nmedication\tO\n,\tO\nwhich\tO\ncan\tO\nbe\tO\novercome\tO\nby\tO\nelevating\tO\nthe\tO\npH\tO\nto\tO\na\tO\nneutral\tO\nlevel\tO\n.\tO\n\nThe\tO\nuse\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\ndidanosine\tB-Chemical\n(\tO\nddI\tB-Chemical\n)\tO\nin\tO\nHIV\tB-Disease\nantibody\tI-Disease\n-\tI-Disease\npositive\tI-Disease\nindividuals\tO\nintolerant\tO\nto\tO\nzidovudine\tB-Chemical\n(\tO\nAZT\tB-Chemical\n)\tO\n\nOne\tO\nhundred\tO\nand\tO\nfifty\tO\n-\tO\none\tO\npatients\tO\nintolerant\tO\nto\tO\nzidovudine\tB-Chemical\n(\tO\nAZT\tB-Chemical\n)\tO\nreceived\tO\ndidanosine\tB-Chemical\n(\tO\nddI\tB-Chemical\n)\tO\nto\tO\na\tO\nmaximum\tO\ndose\tO\nof\tO\n12\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n.\tO\n\nPatient\tO\nresponse\tO\nwas\tO\nassessed\tO\nusing\tO\nchanges\tO\nin\tO\nCD4\tO\n+\tO\nlymphocyte\tO\nsubset\tO\ncount\tO\n,\tO\nHIV\tO\np24\tO\nantigen\tO\n,\tO\nweight\tO\n,\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nSeventy\tO\npatients\tO\ndeveloped\tO\nmajor\tO\nopportunistic\tB-Disease\ninfections\tI-Disease\nwhilst\tO\non\tO\ntherapy\tO\n;\tO\nthis\tO\nwas\tO\nthe\tO\nfirst\tO\nAIDS\tB-Disease\ndiagnosis\tO\nin\tO\n17\tO\n.\tO\n\nOnly\tO\nminor\tO\nchanges\tO\nin\tO\nCD4\tO\n+\tO\nlymphocyte\tO\nsubset\tO\ncount\tO\nwere\tO\nobserved\tO\nin\tO\nAIDS\tB-Disease\npatients\tO\n,\tO\nalthough\tO\na\tO\nmore\tO\nsignificant\tO\nrise\tO\noccurred\tO\nin\tO\nthose\tO\nwith\tO\nearlier\tO\nstages\tO\nof\tO\ndisease\tO\n.\tO\n\nOf\tO\nthose\tO\npositive\tO\nfor\tO\np24\tO\nantigen\tO\nat\tO\nthe\tO\ncommencement\tO\nof\tO\nthe\tO\nstudy\tO\n67\tO\n%\tO\nshowed\tO\na\tO\npositive\tO\nresponse\tO\n,\tO\nand\tO\nthis\tO\nwas\tO\nmost\tO\nlikely\tO\nin\tO\nthose\tO\nwith\tO\nCD4\tO\n+\tO\nlymphocyte\tO\nsubset\tO\ncounts\tO\nabove\tO\n100\tO\nmm3\tO\n.\tO\n\nA\tO\npositive\tO\nweight\tO\nresponse\tO\nwas\tO\nseen\tO\nin\tO\n16\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nMost\tO\npatients\tO\nshowed\tO\nimprovement\tO\nin\tO\nindividual\tO\nparameters\tO\nand\tO\nglobal\tO\nscore\tO\nof\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nAdverse\tO\nreactions\tO\npossibly\tO\nattributable\tO\nto\tO\ndidanosine\tB-Chemical\nwere\tO\ncommon\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nside\tO\n-\tO\neffect\tO\nwas\tO\ndiarrhoea\tB-Disease\n,\tO\nwhich\tO\nresulted\tO\nin\tO\ncessation\tO\nof\tO\ntherapy\tO\nin\tO\n19\tO\nindividuals\tO\n.\tO\n\nPeripheral\tB-Disease\nneuropathy\tI-Disease\noccurred\tO\nin\tO\n12\tO\npatients\tO\nand\tO\npancreatitis\tB-Disease\nin\tO\nsix\tO\n.\tO\n\nThirteen\tO\npatients\tO\ndeveloped\tO\na\tO\nraised\tO\nserum\tO\namylase\tO\nwithout\tO\nabdominal\tB-Disease\npain\tI-Disease\n.\tO\n\nSeven\tO\npatients\tO\ndeveloped\tO\nglucose\tB-Disease\ntolerance\tI-Disease\ncurves\tI-Disease\ncharacteristic\tO\nof\tO\ndiabetes\tB-Disease\nbut\tO\nthese\tO\nwere\tO\nmild\tO\n,\tO\ndid\tO\nnot\tO\nrequire\tO\ntreatment\tO\nand\tO\nreturned\tO\nto\tO\nnormal\tO\non\tO\nceasing\tO\ndidanosine\tB-Chemical\n.\tO\n\nImmunohistochemical\tO\nstudies\tO\nwith\tO\nantibodies\tO\nto\tO\nneurofilament\tO\nproteins\tO\non\tO\naxonal\tB-Disease\ndamage\tI-Disease\nin\tO\nexperimental\tO\nfocal\tO\nlesions\tO\nin\tO\nrat\tO\n.\tO\n\nImmunohistochemistry\tO\nwith\tO\nmonoclonal\tO\nantibodies\tO\nagainst\tO\nneurofilament\tO\n(\tO\nNF\tO\n)\tO\nproteins\tO\nof\tO\nmiddle\tO\nand\tO\nhigh\tO\nmolecular\tO\nweight\tO\nclass\tO\n,\tO\nNF\tO\n-\tO\nM\tO\nand\tO\nNF\tO\n-\tO\nH\tO\n,\tO\nwas\tO\nused\tO\nto\tO\nstudy\tO\naxonal\tB-Disease\ninjury\tI-Disease\nin\tO\nthe\tO\nborderzone\tO\nof\tO\nfocal\tO\nlesions\tO\nin\tO\nrats\tO\n.\tO\n\nFocal\tO\ninjury\tB-Disease\nin\tI-Disease\nthe\tI-Disease\ncortex\tI-Disease\nwas\tO\nproduced\tO\nby\tO\ninfusion\tO\nof\tO\nlactate\tB-Chemical\nat\tO\nacid\tO\npH\tO\nor\tO\nby\tO\nstab\tO\ncaused\tO\nby\tO\nneedle\tO\ninsertion\tO\n.\tO\n\nInfarcts\tB-Disease\nin\tI-Disease\nsubstantia\tI-Disease\nnigra\tI-Disease\npars\tI-Disease\nreticulata\tI-Disease\nwere\tO\nevoked\tO\nby\tO\nprolonged\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n.\tO\n\nImmunohistochemical\tO\nstaining\tO\nfor\tO\nNFs\tO\nshowed\tO\ncharacteristic\tO\nterminal\tO\nclubs\tO\nof\tO\naxons\tO\nin\tO\nthe\tO\nborderzone\tO\nof\tO\nlesions\tO\n.\tO\n\nDifferences\tO\nin\tO\nthe\tO\nlabelling\tO\npattern\tO\noccurred\tO\nwith\tO\ndifferent\tO\nantibodies\tO\nwhich\tO\napparently\tO\ndepended\tO\non\tO\nmolecular\tO\nweight\tO\nclass\tO\nof\tO\nNFs\tO\nand\tO\nphosphorylation\tO\nstate\tO\n.\tO\n\nThese\tO\nimmunohistochemical\tO\nchanges\tO\nof\tO\nNFs\tO\ncan\tO\nserve\tO\nas\tO\na\tO\nmarker\tO\nfor\tO\naxonal\tB-Disease\ndamage\tI-Disease\nin\tO\nvarious\tO\nexperimental\tO\ntraumatic\tB-Disease\nor\tO\nischemic\tO\nlesions\tO\n.\tO\n\nPharmacokinetic\tO\nand\tO\nclinical\tO\nstudies\tO\nin\tO\npatients\tO\nwith\tO\ncimetidine\tB-Chemical\n-\tO\nassociated\tO\nmental\tO\nconfusion\tB-Disease\n.\tO\n\n15\tO\ncases\tO\nof\tO\ncimetidine\tB-Chemical\n-\tO\nassociated\tO\nmental\tO\nconfusion\tB-Disease\nhave\tO\nbeen\tO\nreported\tO\n.\tO\n\nIn\tO\norder\tO\nthat\tO\nthis\tO\nsyndrome\tO\nmight\tO\nbe\tO\ninvestigated\tO\nchanges\tO\nin\tO\nmental\tO\nstatus\tO\n(\tO\nM\tO\n.\tO\nS\tO\n.\tO\n)\tO\nwere\tO\ncorrelated\tO\nwith\tO\nserum\tO\nconcentrations\tO\nand\tO\nrenal\tO\nand\tO\nhepatic\tO\nfunction\tO\nin\tO\n36\tO\npatients\tO\n,\tO\n30\tO\npatients\tO\nhad\tO\nno\tO\nM\tO\n.\tO\nS\tO\n.\tO\nchange\tO\non\tO\ncimetidine\tB-Chemical\nand\tO\n6\tO\nhad\tO\nmoderate\tO\nto\tO\nsevere\tO\nchanges\tO\n.\tO\n\nThese\tO\n6\tO\npatients\tO\nhad\tO\nboth\tO\nrenal\tB-Disease\nand\tI-Disease\nliver\tI-Disease\ndysfunction\tI-Disease\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nas\tO\nwell\tO\nas\tO\ncimetidine\tB-Chemical\ntrough\tO\n-\tO\nconcentrations\tO\nof\tO\nmore\tO\nthan\tO\n1\tO\n.\tO\n25\tO\nmicrogram\tO\n/\tO\nml\tO\n(\tO\nP\tO\nless\tO\nthan\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\nseverity\tO\nof\tO\nM\tO\n.\tO\nS\tO\n.\tO\nchanges\tO\nincreased\tO\nas\tO\ntrough\tO\n-\tO\nconcentrations\tO\nrose\tO\n,\tO\n5\tO\npatients\tO\nhad\tO\nlumbar\tO\npuncture\tO\n.\tO\n\nThe\tO\ncerebrospinal\tO\nfluid\tO\n:\tO\nserum\tO\nratio\tO\nof\tO\ncimetidine\tB-Chemical\nconcentrations\tO\nwas\tO\n0\tO\n.\tO\n24\tO\n:\tO\n1\tO\nand\tO\nindicates\tO\nthat\tO\ncimetidine\tB-Chemical\npasses\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n;\tO\nit\tO\nalso\tO\nraises\tO\nthe\tO\npossibility\tO\nthat\tO\nM\tO\n.\tO\nS\tO\n.\tO\nchanges\tO\nare\tO\ndue\tO\nto\tO\nblockade\tO\nof\tO\nhistamine\tB-Chemical\nH2\tO\n-\tO\nreceptors\tO\nin\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nPatients\tO\nlikely\tO\nto\tO\nhave\tO\nboth\tO\nraised\tO\ntrough\tO\n-\tO\nconcentrations\tO\nand\tO\nmental\tO\nconfusion\tB-Disease\nare\tO\nthose\tO\nwith\tO\nboth\tO\nsevere\tO\nrenal\tB-Disease\nand\tI-Disease\nhepatic\tI-Disease\ndysfunction\tI-Disease\n.\tO\n\nThey\tO\nshould\tO\nbe\tO\nclosely\tO\nobserved\tO\nand\tO\nshould\tO\nbe\tO\ngiven\tO\nreduced\tO\ndoses\tO\nof\tO\ncimetidine\tB-Chemical\n.\tO\n\nProspective\tO\nstudy\tO\nof\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\neffects\tO\nof\tO\nsomatostatin\tO\nanalog\tO\n(\tO\noctreotide\tB-Chemical\n)\tO\non\tO\ngallbladder\tO\nfunction\tO\nand\tO\ngallstone\tB-Disease\nformation\tO\nin\tO\nChinese\tO\nacromegalic\tB-Disease\npatients\tO\n.\tO\n\nThis\tO\narticle\tO\nreports\tO\nthe\tO\nchanges\tO\nin\tO\ngallbladder\tO\nfunction\tO\nexamined\tO\nby\tO\nultrasonography\tO\nin\tO\n20\tO\nChinese\tO\npatients\tO\nwith\tO\nactive\tO\nacromegaly\tB-Disease\ntreated\tO\nwith\tO\nsc\tO\ninjection\tO\nof\tO\nthe\tO\nsomatostatin\tO\nanalog\tO\noctreotide\tB-Chemical\nin\tO\ndosages\tO\nof\tO\n300\tO\n-\tO\n1500\tO\nmicrograms\tO\n/\tO\nday\tO\nfor\tO\na\tO\nmean\tO\nof\tO\n24\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n13\tO\n.\tO\n9\tO\nmonths\tO\n.\tO\n\nDuring\tO\ntreatment\tO\nwith\tO\noctreotide\tB-Chemical\n,\tO\n17\tO\npatients\tO\ndeveloped\tO\nsludge\tO\n,\tO\n10\tO\nhad\tO\ngallstones\tB-Disease\n,\tO\nand\tO\n1\tO\ndeveloped\tO\nacute\tB-Disease\ncholecystitis\tI-Disease\nrequiring\tO\nsurgery\tO\n.\tO\n\nIn\tO\nall\tO\nof\tO\n7\tO\npatients\tO\nexamined\tO\nacutely\tO\n,\tO\ngallbladder\tO\ncontractility\tO\nwas\tO\ninhibited\tO\nafter\tO\na\tO\nsingle\tO\n100\tO\n-\tO\nmicrograms\tO\ninjection\tO\n.\tO\n\nIn\tO\n8\tO\npatients\tO\nfollowed\tO\nfor\tO\n24\tO\nweeks\tO\n,\tO\ngallbladder\tO\ncontractility\tO\nremained\tO\ndepressed\tB-Disease\nthroughout\tO\ntherapy\tO\n.\tO\n\nAfter\tO\nwithdrawal\tO\nof\tO\noctreotide\tB-Chemical\nin\tO\n10\tO\npatients\tO\nwithout\tO\ngallstones\tB-Disease\n,\tO\n8\tO\npatients\tO\nassessed\tO\nhad\tO\nreturn\tO\nof\tO\nnormal\tO\ngallbladder\tO\ncontractility\tO\nwithin\tO\n1\tO\nmonth\tO\n.\tO\n\nIn\tO\n8\tO\nof\tO\nthe\tO\nremaining\tO\n10\tO\npatients\tO\nwho\tO\ndeveloped\tO\ngallstones\tB-Disease\nduring\tO\ntreatment\tO\n,\tO\ngallbladder\tO\ncontractility\tO\nnormalized\tO\nin\tO\n5\tO\npatients\tO\n(\tO\n3\tO\nof\tO\nwhom\tO\nhas\tO\ndisappearance\tO\nof\tO\ntheir\tO\nstones\tO\nwithin\tO\n3\tO\nweeks\tO\n)\tO\n,\tO\nand\tO\nremained\tO\ndepressed\tB-Disease\nin\tO\n3\tO\n(\tO\n2\tO\nof\tO\nwhom\tO\nhad\tO\nstones\tO\npresent\tO\nat\tO\n6\tO\nmonths\tO\n)\tO\n.\tO\n\nOur\tO\nresults\tO\nsuggest\tO\nthat\tO\nthe\tO\nsuppression\tO\nof\tO\ngallbladder\tO\ncontractility\tO\nis\tO\nthe\tO\ncause\tO\nof\tO\nthe\tO\nsuccessive\tO\nformation\tO\nof\tO\nbile\tO\nsludge\tO\n,\tO\ngallstones\tB-Disease\n,\tO\nand\tO\ncholecystitis\tB-Disease\nduring\tO\noctreotide\tB-Chemical\ntherapy\tO\nin\tO\nChinese\tO\nacromegalic\tB-Disease\npatients\tO\n.\tO\n\nIt\tO\nis\tO\ntherefore\tO\nvery\tO\nimportant\tO\nto\tO\nfollow\tO\nthe\tO\nchanges\tO\nof\tO\ngallbladder\tO\nfunction\tO\nduring\tO\nlong\tO\n-\tO\nterm\tO\noctreotide\tB-Chemical\ntherapy\tO\nof\tO\nacromegalic\tB-Disease\npatients\tO\n.\tO\n\nIncrease\tO\nof\tO\nParkinson\tB-Disease\ndisability\tI-Disease\nafter\tO\nfluoxetine\tB-Chemical\nmedication\tO\n.\tO\n\nDepression\tB-Disease\nis\tO\na\tO\nmajor\tO\nclinical\tO\nfeature\tO\nof\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\nincreased\tO\namount\tO\nof\tO\nmotor\tB-Disease\ndisability\tI-Disease\nin\tO\nfour\tO\npatients\tO\nwith\tO\nidiopathic\tB-Disease\nParkinson\tI-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\nafter\tO\nexposure\tO\nto\tO\nthe\tO\nantidepressant\tB-Chemical\nfluoxetine\tB-Chemical\n.\tO\n\nThe\tO\npossibility\tO\nof\tO\na\tO\nclinically\tO\nrelevant\tO\ndopamine\tB-Chemical\n-\tO\nantagonistic\tO\ncapacity\tO\nof\tO\nfluoxetine\tB-Chemical\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\npatients\tO\nmust\tO\nbe\tO\nconsidered\tO\n.\tO\n\nSinus\tB-Disease\narrest\tI-Disease\nassociated\tO\nwith\tO\ncontinuous\tO\n-\tO\ninfusion\tO\ncimetidine\tB-Chemical\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nintermittent\tO\nintravenous\tO\ninfusions\tO\nof\tO\ncimetidine\tB-Chemical\nis\tO\ninfrequently\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nbradyarrhythmias\tB-Disease\n.\tO\n\nA\tO\n40\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwith\tO\nleukemia\tB-Disease\nand\tO\nno\tO\nhistory\tO\nof\tO\ncardiac\tB-Disease\ndisease\tI-Disease\ndeveloped\tO\nrecurrent\tO\n,\tO\nbrief\tO\nepisodes\tO\nof\tO\napparent\tO\nsinus\tB-Disease\narrest\tI-Disease\nwhile\tO\nreceiving\tO\ncontinuous\tO\n-\tO\ninfusion\tO\ncimetidine\tB-Chemical\n50\tO\nmg\tO\n/\tO\nhour\tO\n.\tO\n\nThe\tO\narrhythmias\tB-Disease\nwere\tO\ntemporally\tO\nrelated\tO\nto\tO\ncimetidine\tB-Chemical\nadministration\tO\n,\tO\ndisappeared\tO\nafter\tO\ndechallenge\tO\n,\tO\nand\tO\ndid\tO\nnot\tO\nrecur\tO\nduring\tO\nranitidine\tB-Chemical\ntreatment\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nreported\tO\ncase\tO\nof\tO\nsinus\tB-Disease\narrest\tI-Disease\nassociated\tO\nwith\tO\ncontinuous\tO\n-\tO\ninfusion\tO\ncimetidine\tB-Chemical\n.\tO\n\nPhase\tO\nII\tO\ntrial\tO\nof\tO\nvinorelbine\tB-Chemical\nin\tO\nmetastatic\tO\nsquamous\tB-Disease\ncell\tI-Disease\nesophageal\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nEuropean\tO\nOrganization\tO\nfor\tO\nResearch\tO\nand\tO\nTreatment\tO\nof\tO\nCancer\tB-Disease\nGastrointestinal\tO\nTreat\tO\nCancer\tB-Disease\nCooperative\tO\nGroup\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nresponse\tO\nrate\tO\nand\tO\ntoxic\tO\neffects\tO\nof\tO\nvinorelbine\tB-Chemical\n(\tO\nVNB\tB-Chemical\n)\tO\nadministered\tO\nas\tO\na\tO\nsingle\tO\nagent\tO\nin\tO\nmetastatic\tO\nsquamous\tB-Disease\ncell\tI-Disease\nesophageal\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nForty\tO\n-\tO\nsix\tO\neligible\tO\npatients\tO\nwith\tO\nmeasurable\tO\nlesions\tO\nwere\tO\nincluded\tO\nand\tO\nwere\tO\nstratified\tO\naccording\tO\nto\tO\nprevious\tO\nchemotherapy\tO\n.\tO\n\nThirty\tO\npatients\tO\nwithout\tO\nprior\tO\nchemotherapy\tO\nand\tO\n16\tO\npretreated\tO\nwith\tO\ncisplatin\tB-Chemical\n-\tO\nbased\tO\nchemotherapy\tO\nwere\tO\nassessable\tO\nfor\tO\ntoxicity\tB-Disease\nand\tO\nresponse\tO\n.\tO\n\nVNB\tB-Chemical\nwas\tO\nadministered\tO\nweekly\tO\nas\tO\na\tO\n25\tO\n-\tO\nmg\tO\n/\tO\nm2\tO\nshort\tO\nintravenous\tO\n(\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\ninfusion\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSix\tO\nof\tO\n30\tO\npatients\tO\n(\tO\n20\tO\n%\tO\n)\tO\nwithout\tO\nprior\tO\nchemotherapy\tO\nachieved\tO\na\tO\npartial\tO\nresponse\tO\n(\tO\nPR\tO\n)\tO\n(\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n,\tO\n8\tO\n%\tO\nto\tO\n39\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmedian\tO\nduration\tO\nof\tO\nresponse\tO\nwas\tO\n21\tO\nweeks\tO\n(\tO\nrange\tO\n,\tO\n17\tO\nto\tO\n28\tO\n)\tO\n.\tO\n\nOne\tO\nof\tO\n16\tO\npatients\tO\n(\tO\n6\tO\n%\tO\n)\tO\nwith\tO\nprior\tO\nchemotherapy\tO\nhad\tO\na\tO\ncomplete\tO\nresponse\tO\n(\tO\nCR\tO\n)\tO\nof\tO\n31\tO\nweeks\tO\n'\tO\nduration\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n0\tO\n%\tO\nto\tO\n30\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\noverall\tO\nresponse\tO\nrate\tO\n(\tO\nWorld\tO\nHealth\tO\nOrganization\tO\n[\tO\nWHO\tO\n]\tO\ncriteria\tO\n)\tO\nwas\tO\n15\tO\n%\tO\n(\tO\nCR\tO\n,\tO\n2\tO\n%\tO\n;\tO\nPR\tO\n13\tO\n%\tO\n;\tO\n95\tO\n%\tO\nCI\tO\n,\tO\n6\tO\n%\tO\nto\tO\n29\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmedian\tO\ndose\tO\n-\tO\nintensity\tO\n(\tO\nDI\tO\n)\tO\nwas\tO\n20\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nwk\tO\n.\tO\n\nVNB\tB-Chemical\nwas\tO\nwell\tO\ntolerated\tO\nand\tO\nzero\tO\ninstances\tO\nof\tO\nWHO\tO\ngrade\tO\n4\tO\nnonhematologic\tO\ntoxicity\tB-Disease\noccurred\tO\n.\tO\n\nAt\tO\nleast\tO\none\tO\nepisode\tO\nof\tO\ngrade\tO\n3\tO\nor\tO\n4\tO\ngranulocytopenia\tB-Disease\nwas\tO\nseen\tO\nin\tO\n59\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nA\tO\ngrade\tO\n2\tO\nor\tO\n3\tO\ninfection\tB-Disease\noccurred\tO\nin\tO\n16\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nbut\tO\nno\tO\ntoxic\tO\ndeaths\tB-Disease\noccurred\tO\n.\tO\n\nOther\tO\nside\tO\neffects\tO\nwere\tO\nrare\tO\n,\tO\nand\tO\nperipheral\tB-Disease\nneurotoxicity\tI-Disease\nhas\tO\nbeen\tO\nminor\tO\n(\tO\n26\tO\n%\tO\ngrade\tO\n1\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nVNB\tB-Chemical\nis\tO\nan\tO\nactive\tO\nagent\tO\nin\tO\nmetastatic\tO\nesophageal\tB-Disease\nsquamous\tI-Disease\ncell\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nGiven\tO\nits\tO\nexcellent\tO\ntolerance\tO\nprofile\tO\nand\tO\nlow\tO\ntoxicity\tB-Disease\n,\tO\nfurther\tO\nevaluation\tO\nof\tO\nVNB\tB-Chemical\nin\tO\ncombination\tO\ntherapy\tO\nis\tO\nwarranted\tO\n.\tO\n\nEvaluation\tO\nof\tO\nadverse\tO\nreactions\tO\nof\tO\naponidine\tB-Chemical\nhydrochloride\tI-Chemical\nophthalmic\tO\nsolution\tO\n.\tO\n\nWe\tO\nprospectively\tO\nevaluated\tO\nthe\tO\nadverse\tO\nreactions\tO\nof\tO\napraclonidine\tB-Chemical\nin\tO\n20\tO\nnormal\tO\nvolunteers\tO\nby\tO\ninstilling\tO\na\tO\nsingle\tO\ndrop\tO\nof\tO\n1\tO\n%\tO\napraclonidine\tB-Chemical\nin\tO\ntheir\tO\nright\tO\neyes\tO\n.\tO\n\nExaminations\tO\n,\tO\nincluding\tO\nblood\tO\npressure\tO\n,\tO\npulse\tO\nrate\tO\n,\tO\nconjunctiva\tO\nand\tO\ncornea\tO\n,\tO\nintraocular\tO\npressure\tO\n(\tO\nIOP\tO\n)\tO\n,\tO\npupil\tO\ndiameter\tO\n,\tO\nbasal\tO\ntear\tO\nsecretion\tO\nand\tO\nmargin\tO\nreflex\tO\ndistance\tO\nof\tO\nboth\tO\nupper\tO\nand\tO\nlower\tO\neyelids\tO\n,\tO\nwere\tO\nperformed\tO\nprior\tO\nto\tO\nentry\tO\nand\tO\nat\tO\n1\tO\n,\tO\n3\tO\n,\tO\n5\tO\nand\tO\n7\tO\nhours\tO\nafter\tO\ninstillation\tO\n.\tO\n\nThe\tO\nocular\tB-Disease\nhypotensive\tI-Disease\neffects\tO\nwere\tO\nstatistically\tO\nsignificant\tO\nfor\tO\napraclonidine\tB-Chemical\n-\tO\ntreated\tO\neyes\tO\nthroughout\tO\nthe\tO\nstudy\tO\nand\tO\nalso\tO\nstatistically\tO\nsignificant\tO\nfor\tO\ncontralateral\tO\neyes\tO\nfrom\tO\nthree\tO\nhours\tO\nafter\tO\ntopical\tO\nadministration\tO\nof\tO\n1\tO\n%\tO\napraclonidine\tB-Chemical\n.\tO\n\nDecreases\tB-Disease\nin\tI-Disease\nsystolic\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nwere\tO\nstatistically\tO\n,\tO\nbut\tO\nnot\tO\nclinically\tO\n,\tO\nsignificant\tO\n.\tO\n\nNo\tO\nsignificant\tO\nchanges\tO\nin\tO\ndiastolic\tO\nblood\tO\npressure\tO\n,\tO\npulse\tO\nrate\tO\nand\tO\nbasal\tO\ntear\tO\nsecretion\tO\nwere\tO\nnoted\tO\n.\tO\n\nConjunctival\tB-Disease\nblanching\tI-Disease\nand\tO\nmydriasis\tB-Disease\nwere\tO\ncommonly\tO\nfound\tO\n.\tO\n\nUpper\tO\nlid\tO\nretraction\tO\nwas\tO\nfrequently\tO\nnoted\tO\n.\tO\n\nWhile\tO\nthe\tO\nelevations\tO\nof\tO\nthe\tO\nupper\tO\nlid\tO\nmargin\tO\nin\tO\nmost\tO\nsubjects\tO\nwere\tO\nnot\tO\nmore\tO\nthan\tO\n2\tO\nmm\tO\nand\tO\ndid\tO\nnot\tO\ncause\tO\nnoticeable\tO\nchange\tO\nin\tO\nappearance\tO\n,\tO\none\tO\nsubject\tO\nsuffered\tO\nfrom\tO\nmechanical\tO\nentropion\tB-Disease\nand\tO\nmarked\tO\ncorneal\tB-Disease\nabrasion\tI-Disease\n3\tO\nhours\tO\nafter\tO\ninstillation\tO\nof\tO\nthe\tO\nmedication\tO\n.\tO\n\nThis\tO\nmay\tO\nwell\tO\nbe\tO\na\tO\nparticularly\tO\nnotable\tO\nfinding\tO\nin\tO\nAsian\tO\npeople\tO\n.\tO\n\nThiopentone\tB-Chemical\npretreatment\tO\nfor\tO\npropofol\tB-Chemical\ninjection\tO\npain\tB-Disease\nin\tO\nambulatory\tO\npatients\tO\n.\tO\n\nThis\tO\nstudy\tO\ninvestigated\tO\npropofol\tB-Chemical\ninjection\tO\npain\tB-Disease\nin\tO\npatients\tO\nundergoing\tO\nambulatory\tO\nanaesthesia\tO\n.\tO\n\nIn\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\ntrial\tO\n,\tO\n90\tO\nwomen\tO\nwere\tO\nallocated\tO\nto\tO\nreceive\tO\none\tO\nof\tO\nthree\tO\ntreatments\tO\nprior\tO\nto\tO\ninduction\tO\nof\tO\nanaesthesia\tO\nwith\tO\npropofol\tB-Chemical\n.\tO\n\nPatients\tO\nin\tO\nGroup\tO\nC\tO\nreceived\tO\n2\tO\nml\tO\nnormal\tO\nsaline\tO\n,\tO\nGroup\tO\nL\tO\n,\tO\n2\tO\nml\tO\n,\tO\nlidocaine\tB-Chemical\n2\tO\n%\tO\n(\tO\n40\tO\nmg\tO\n)\tO\nand\tO\nGroup\tO\nT\tO\n,\tO\n2\tO\nml\tO\nthiopentone\tB-Chemical\n2\tO\n.\tO\n5\tO\n%\tO\n(\tO\n50\tO\nmg\tO\n)\tO\n.\tO\n\nVenous\tO\ndiscomfort\tO\nwas\tO\nassessed\tO\nwith\tO\na\tO\nvisual\tO\nanalogue\tO\nscale\tO\n(\tO\nVAS\tO\n)\tO\n5\tO\n-\tO\n15\tO\nsec\tO\nafter\tO\ncommencing\tO\npropofol\tB-Chemical\nadministration\tO\nusing\tO\nan\tO\ninfusion\tO\npump\tO\n(\tO\nrate\tO\n1000\tO\nmicrograms\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nmin\tO\n-\tO\n1\tO\n)\tO\n.\tO\n\nLoss\tB-Disease\nof\tI-Disease\nconsciousness\tI-Disease\noccurred\tO\nin\tO\n60\tO\n-\tO\n90\tO\nsec\tO\n.\tO\n\nVisual\tO\nanalogue\tO\nscores\tO\n(\tO\nmean\tO\n+\tO\n/\tO\n-\tO\nSD\tO\n)\tO\nduring\tO\ninduction\tO\nwere\tO\nlower\tO\nin\tO\nGroups\tO\nL\tO\n(\tO\n3\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n5\tO\n)\tO\nand\tO\nT\tO\n(\tO\n4\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n7\tO\n)\tO\nthan\tO\nin\tO\nGroup\tO\nC\tO\n(\tO\n5\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n3\tO\n)\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n0031\tO\n.\tO\n\nThe\tO\nincidence\tO\nof\tO\nvenous\tO\ndiscomfort\tO\nwas\tO\nlower\tO\nin\tO\nGroup\tO\nL\tO\n(\tO\n76\tO\n.\tO\n6\tO\n%\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\nthan\tO\nin\tO\nGroup\tO\nC\tO\n(\tO\n100\tO\n%\tO\n)\tO\nbut\tO\nnot\tO\ndifferent\tO\nfrom\tO\nGroup\tO\nT\tO\n(\tO\n90\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nVAS\tO\nscores\tO\nfor\tO\nrecall\tO\nof\tO\npain\tB-Disease\nin\tO\nthe\tO\nrecovery\tO\nroom\tO\nwere\tO\ncorrelated\tO\nwith\tO\nthe\tO\nVAS\tO\nscores\tO\nduring\tO\ninduction\tO\n(\tO\nr\tO\n=\tO\n0\tO\n.\tO\n7045\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nRecovery\tO\nroom\tO\ndischarge\tO\ntimes\tO\nwere\tO\nsimilar\tO\n:\tO\nC\tO\n(\tO\n75\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n19\tO\n.\tO\n4\tO\nmin\tO\n)\tO\n;\tO\nL\tO\n73\tO\n.\tO\n6\tO\n+\tO\n/\tO\n-\tO\n21\tO\n.\tO\n6\tO\nmin\tO\n)\tO\n;\tO\nT\tO\n(\tO\n77\tO\n.\tO\n1\tO\n+\tO\n/\tO\n-\tO\n18\tO\n.\tO\n9\tO\nmin\tO\n)\tO\n.\tO\n\nAssessing\tO\ntheir\tO\noverall\tO\nsatisfaction\tO\n,\tO\n89\tO\n.\tO\n7\tO\n%\tO\nwould\tO\nchoose\tO\npropofol\tB-Chemical\nanaesthesia\tO\nagain\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nlidocaine\tB-Chemical\nreduces\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\npropofol\tB-Chemical\ninjection\tO\npain\tB-Disease\nin\tO\nambulatory\tO\npatients\tO\nwhereas\tO\nthiopentone\tB-Chemical\nonly\tO\nreduces\tO\nits\tO\nseverity\tO\n.\tO\n\nPersistent\tO\nparalysis\tB-Disease\nafter\tO\nprolonged\tO\nuse\tO\nof\tO\natracurium\tB-Chemical\nin\tO\nthe\tO\nabsence\tO\nof\tO\ncorticosteroids\tO\n.\tO\n\nNeuromuscular\tO\nblocking\tO\nagents\tO\n(\tO\nNMBAs\tO\n)\tO\nare\tO\noften\tO\nused\tO\nfor\tO\npatients\tO\nrequiring\tO\nprolonged\tO\nmechanical\tO\nventilation\tO\n.\tO\n\nReports\tO\nof\tO\npersistent\tO\nparalysis\tB-Disease\nafter\tO\nthe\tO\ndiscontinuance\tO\nof\tO\nthese\tO\ndrugs\tO\nhave\tO\nmost\tO\noften\tO\ninvolved\tO\naminosteroid\tO\n-\tO\nbased\tO\nNMBAs\tO\nsuch\tO\nas\tO\nvecuronium\tB-Chemical\nbromide\tI-Chemical\n,\tO\nespecially\tO\nwhen\tO\nused\tO\nin\tO\nconjunction\tO\nwith\tO\ncorticosteroids\tO\n.\tO\n\nAtracurium\tB-Chemical\nbesylate\tI-Chemical\n,\tO\na\tO\nshort\tO\n-\tO\nacting\tO\nbenzylisoquinolinium\tB-Chemical\nNMBA\tO\nthat\tO\nis\tO\neliminated\tO\nindependently\tO\nof\tO\nrenal\tO\nor\tO\nhepatic\tO\nfunction\tO\n,\tO\nhas\tO\nalso\tO\nbeen\tO\nassociated\tO\nwith\tO\npersistent\tO\nparalysis\tB-Disease\n,\tO\nbut\tO\nonly\tO\nwhen\tO\nused\tO\nwith\tO\ncorticosteroids\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\natracurium\tB-Chemical\n-\tO\nrelated\tO\nparalysis\tB-Disease\npersisting\tO\nfor\tO\napproximately\tO\n50\tO\nhours\tO\nin\tO\na\tO\npatient\tO\nwho\tO\nwas\tO\nnot\tO\ntreated\tO\nwith\tO\ncorticosteroids\tO\n.\tO\n\nA\tO\nphase\tO\nI\tO\n/\tO\nII\tO\nstudy\tO\nof\tO\npaclitaxel\tB-Chemical\nplus\tO\ncisplatin\tB-Chemical\nas\tO\nfirst\tO\n-\tO\nline\tO\ntherapy\tO\nfor\tO\nhead\tB-Disease\nand\tI-Disease\nneck\tI-Disease\ncancers\tI-Disease\n:\tO\npreliminary\tO\nresults\tO\n.\tO\n\nImproved\tO\noutcomes\tO\namong\tO\npatients\tO\nwith\tO\nhead\tB-Disease\nand\tI-Disease\nneck\tI-Disease\ncarcinomas\tI-Disease\nrequire\tO\ninvestigations\tO\nof\tO\nnew\tO\ndrugs\tO\nfor\tO\ninduction\tO\ntherapy\tO\n.\tO\n\nPreliminary\tO\nresults\tO\nof\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nstudy\tO\nof\tO\nsingle\tO\n-\tO\nagent\tO\npaclitaxel\tB-Chemical\n(\tO\nTaxol\tB-Chemical\n;\tO\nBristol\tO\n-\tO\nMyers\tO\nSquibb\tO\nCompany\tO\n,\tO\nPrinceton\tO\n,\tO\nNJ\tO\n)\tO\nreported\tO\na\tO\n37\tO\n%\tO\nresponse\tO\nrate\tO\nin\tO\npatients\tO\nwith\tO\nhead\tB-Disease\nand\tI-Disease\nneck\tI-Disease\ncancer\tI-Disease\n,\tO\nand\tO\nthe\tO\npaclitaxel\tB-Chemical\n/\tO\ncisplatin\tB-Chemical\ncombination\tO\nhas\tO\nbeen\tO\nused\tO\nsuccessfully\tO\nand\tO\nhas\tO\nsignificantly\tO\nimproved\tO\nmedian\tO\nresponse\tO\nduration\tO\nin\tO\novarian\tB-Disease\ncancer\tI-Disease\npatients\tO\n.\tO\n\nWe\tO\ninitiated\tO\na\tO\nphase\tO\nI\tO\n/\tO\nII\tO\ntrial\tO\nto\tO\ndetermine\tO\nthe\tO\nresponse\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\nescalating\tO\npaclitaxel\tB-Chemical\ndoses\tO\ncombined\tO\nwith\tO\nfixed\tO\n-\tO\ndose\tO\ncisplatin\tB-Chemical\nwith\tO\ngranulocyte\tO\ncolony\tO\n-\tO\nstimulating\tO\nfactor\tO\nsupport\tO\nin\tO\npatients\tO\nwith\tO\nuntreated\tO\nlocally\tO\nadvanced\tO\ninoperable\tO\nhead\tB-Disease\nand\tI-Disease\nneck\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nTo\tO\ndate\tO\n,\tO\n23\tO\nmen\tO\nwith\tO\na\tO\nmedian\tO\nage\tO\nof\tO\n50\tO\nyears\tO\nand\tO\ngood\tO\nperformance\tO\nstatus\tO\nhave\tO\nentered\tO\nthe\tO\ntrial\tO\n.\tO\n\nPrimary\tO\ntumor\tB-Disease\nsites\tO\nwere\tO\noropharynx\tO\n,\tO\n10\tO\npatients\tO\n;\tO\nhypopharynx\tO\n,\tO\nfour\tO\n;\tO\nlarynx\tO\n,\tO\ntwo\tO\n;\tO\noral\tO\ncavity\tO\n,\tO\nthree\tO\n;\tO\nunknown\tO\nprimary\tO\n,\tO\ntwo\tO\n;\tO\nand\tO\nnasal\tO\ncavity\tO\nand\tO\nparotid\tO\ngland\tO\n,\tO\none\tO\neach\tO\n.\tO\n\nOf\tO\n20\tO\npatients\tO\nevaluable\tO\nfor\tO\ntoxicity\tB-Disease\n,\tO\nfour\tO\nhad\tO\nstage\tO\nIII\tO\nand\tO\n16\tO\nhad\tO\nstage\tO\nIV\tO\ndisease\tO\n.\tO\n\nTreatment\tO\n,\tO\ngiven\tO\nevery\tO\n21\tO\ndays\tO\nfor\tO\na\tO\nmaximum\tO\nof\tO\nthree\tO\ncycles\tO\n,\tO\nconsisted\tO\nof\tO\npaclitaxel\tB-Chemical\nby\tO\n3\tO\n-\tO\nhour\tO\ninfusion\tO\nfollowed\tO\nthe\tO\nnext\tO\nday\tO\nby\tO\na\tO\nfixed\tO\ndose\tO\nof\tO\ncisplatin\tB-Chemical\n(\tO\n75\tO\nmg\tO\n/\tO\nm2\tO\n)\tO\n.\tO\n\nThe\tO\ndose\tO\nlevels\tO\nincorporate\tO\nescalating\tO\npaclitaxel\tB-Chemical\ndoses\tO\n,\tO\nand\tO\nintrapatient\tO\nescalations\tO\nwithin\tO\na\tO\ngiven\tO\ndose\tO\nlevel\tO\nare\tO\npermitted\tO\nif\tO\ntoxicity\tB-Disease\npermits\tO\n.\tO\n\nAt\tO\nthe\tO\ntime\tO\nof\tO\nthis\tO\nwriting\tO\n,\tO\ndose\tO\nlevel\tO\n4\tO\n(\tO\n260\tO\n,\tO\n270\tO\n,\tO\nand\tO\n280\tO\nmg\tO\n/\tO\nm2\tO\n)\tO\nis\tO\nbeing\tO\nevaluated\tO\n;\tO\nthree\tO\npatients\tO\nfrom\tO\nthis\tO\nlevel\tO\nare\tO\nevaluable\tO\n.\tO\n\nWith\tO\npaclitaxel\tB-Chemical\ndoses\tO\nof\tO\n200\tO\nmg\tO\n/\tO\nm2\tO\nand\tO\nhigher\tO\n,\tO\ngranulocyte\tO\ncolony\tO\n-\tO\nstimulating\tO\nfactor\tO\n5\tO\nmicrograms\tO\n/\tO\nkg\tO\n/\tO\nd\tO\nis\tO\ngiven\tO\n(\tO\ndays\tO\n4\tO\nthrough\tO\n12\tO\n)\tO\n.\tO\n\nOf\tO\n18\tO\npatients\tO\nevaluable\tO\nfor\tO\nresponse\tO\n,\tO\nseven\tO\n(\tO\n39\tO\n%\tO\n)\tO\nachieved\tO\na\tO\ncomplete\tO\nresponse\tO\nand\tO\nsix\tO\n(\tO\n33\tO\n%\tO\n)\tO\nachieved\tO\na\tO\npartial\tO\nresponse\tO\n.\tO\n\nThree\tO\npatients\tO\nhad\tO\nno\tO\nchange\tO\nand\tO\ndisease\tO\nprogressed\tO\nin\tO\ntwo\tO\n.\tO\n\nThe\tO\noverall\tO\nresponse\tO\nrate\tO\nis\tO\n72\tO\n%\tO\n.\tO\n\nEleven\tO\nresponding\tO\npatients\tO\nhad\tO\nsubsequent\tO\nsurgery\tO\n/\tO\nradiotherapy\tO\nor\tO\nradical\tO\nradiotherapy\tO\n.\tO\n\nTwo\tO\npathologic\tO\ncomplete\tO\nresponses\tO\nwere\tO\nobserved\tO\nin\tO\npatients\tO\nwho\tO\nhad\tO\nachieved\tO\nclinical\tO\ncomplete\tO\nresponses\tO\n.\tO\n\nAlopecia\tB-Disease\n,\tO\nparesthesias\tB-Disease\n,\tO\nand\tO\narthralgias\tB-Disease\n/\tO\nmyalgias\tB-Disease\nhave\tO\noccurred\tO\nfrequently\tO\n,\tO\nbut\tO\nwith\tO\none\tO\nexception\tO\n(\tO\na\tO\ngrade\tO\n3\tO\nmyalgia\tB-Disease\n)\tO\nthey\tO\nhave\tO\nbeen\tO\ngrade\tO\n1\tO\nor\tO\n2\tO\n.\tO\n\nNo\tO\ndose\tO\n-\tO\nlimiting\tO\nhematologic\tO\ntoxicity\tB-Disease\nhas\tO\nbeen\tO\nseen\tO\n.\tO\n\nPaclitaxel\tB-Chemical\n/\tO\ncisplatin\tB-Chemical\nis\tO\nan\tO\neffective\tO\nfirst\tO\n-\tO\nline\tO\nregimen\tO\nfor\tO\nlocoregionally\tO\nadvanced\tO\nhead\tB-Disease\nand\tI-Disease\nneck\tI-Disease\ncancer\tI-Disease\nand\tO\ncontinued\tO\nstudy\tO\nis\tO\nwarranted\tO\n.\tO\n\nResults\tO\nthus\tO\nfar\tO\nsuggest\tO\nno\tO\ndose\tO\n-\tO\nresponse\tO\neffect\tO\nfor\tO\npaclitaxel\tB-Chemical\ndoses\tO\nabove\tO\n200\tO\nmg\tO\n/\tO\nm2\tO\n.\tO\n\nImprovement\tO\nof\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\ndyskinesia\tB-Disease\nby\tO\npropranolol\tB-Chemical\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nSeven\tO\npatients\tO\nsuffering\tO\nfrom\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\nwith\tO\nseverely\tO\ndisabling\tO\ndyskinesia\tB-Disease\nreceived\tO\nlow\tO\n-\tO\ndose\tO\npropranolol\tB-Chemical\nas\tO\nan\tO\nadjunct\tO\nto\tO\nthe\tO\ncurrently\tO\nused\tO\nmedical\tO\ntreatment\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\n40\tO\n%\tO\nimprovement\tO\nin\tO\nthe\tO\ndyskinesia\tB-Disease\nscore\tO\nwithout\tO\nincrease\tO\nof\tO\nparkinsonian\tB-Disease\nmotor\tB-Disease\ndisability\tI-Disease\n.\tO\n\nBallistic\tO\nand\tO\nchoreic\tO\ndyskinesia\tB-Disease\nwere\tO\nmarkedly\tO\nameliorated\tO\n,\tO\nwhereas\tO\ndystonia\tB-Disease\nwas\tO\nnot\tO\n.\tO\n\nThis\tO\nstudy\tO\nsuggests\tO\nthat\tO\nadministration\tO\nof\tO\nlow\tO\ndoses\tO\nof\tO\nbeta\tO\n-\tO\nblockers\tO\nmay\tO\nimprove\tO\nlevodopa\tB-Chemical\n-\tO\ninduced\tO\nballistic\tO\nand\tO\nchoreic\tO\ndyskinesia\tB-Disease\nin\tO\nPD\tB-Disease\n.\tO\n\nHabitual\tO\nuse\tO\nof\tO\nacetaminophen\tB-Chemical\nas\tO\na\tO\nrisk\tO\nfactor\tO\nfor\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n:\tO\na\tO\ncomparison\tO\nwith\tO\nphenacetin\tB-Chemical\n.\tO\n\nSix\tO\nepidemiologic\tO\nstudies\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\nand\tO\nEurope\tO\nindicate\tO\nthat\tO\nhabitual\tO\nuse\tO\nof\tO\nphenacetin\tB-Chemical\nis\tO\nassociated\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nand\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n(\tO\nESRD\tB-Disease\n)\tO\n,\tO\nwith\tO\na\tO\nrelative\tO\nrisk\tO\nin\tO\nthe\tO\nrange\tO\nof\tO\n4\tO\nto\tO\n19\tO\n.\tO\n\nAs\tO\na\tO\nresult\tO\nof\tO\nthese\tO\nand\tO\nother\tO\nstudies\tO\n,\tO\nphenacetin\tB-Chemical\nhas\tO\nnow\tO\nbeen\tO\nwithdrawn\tO\nfrom\tO\nthe\tO\nmarket\tO\nin\tO\nmost\tO\ncountries\tO\n.\tO\n\nHowever\tO\n,\tO\nthree\tO\ncase\tO\ncontrol\tO\nstudies\tO\n,\tO\none\tO\neach\tO\nin\tO\nNorth\tO\nCarolina\tO\n,\tO\nnorthern\tO\nMaryland\tO\n,\tO\nand\tO\nWest\tO\nBerlin\tO\n,\tO\nGermany\tO\n,\tO\nshowed\tO\nthat\tO\nhabitual\tO\nuse\tO\nof\tO\nacetaminophen\tB-Chemical\nis\tO\nalso\tO\nassociated\tO\nwith\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\nand\tO\nESRD\tB-Disease\n,\tO\nwith\tO\na\tO\nrelative\tO\nrisk\tO\nin\tO\nthe\tO\nrange\tO\nof\tO\n2\tO\nto\tO\n4\tO\n.\tO\n\nThese\tO\nstudies\tO\nsuggest\tO\nthat\tO\nboth\tO\nphenacetin\tB-Chemical\nand\tO\nacetaminophen\tB-Chemical\nmay\tO\ncontribute\tO\nto\tO\nthe\tO\nburden\tO\nof\tO\nESRD\tB-Disease\n,\tO\nwith\tO\nthe\tO\nrisk\tO\nof\tO\nthe\tO\nlatter\tO\nbeing\tO\nsomewhat\tO\nless\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\nformer\tO\n.\tO\n\nThis\tO\napparent\tO\ndifference\tO\nin\tO\nrisk\tO\nmay\tO\nnot\tO\nbe\tO\ndue\tO\nto\tO\ndifferences\tO\nin\tO\nnephrotoxic\tB-Disease\npotential\tO\nof\tO\nthe\tO\ndrugs\tO\nthemselves\tO\n.\tO\n\nA\tO\nlower\tO\nrelative\tO\nrisk\tO\nwould\tO\nbe\tO\nexpected\tO\nfor\tO\nacetaminophen\tB-Chemical\nif\tO\nthe\tO\nrisk\tO\nof\tO\nboth\tO\ndrugs\tO\nin\tO\ncombination\tO\nwith\tO\nother\tO\nanalgesics\tO\nwas\tO\nhigher\tO\nthan\tO\nthe\tO\nrisk\tO\nof\tO\neither\tO\nagent\tO\nalone\tO\n.\tO\n\nThus\tO\n,\tO\nacetaminophen\tB-Chemical\nhas\tO\nbeen\tO\nused\tO\nboth\tO\nas\tO\na\tO\nsingle\tO\nagent\tO\nand\tO\nin\tO\ncombination\tO\nwith\tO\nother\tO\nanalgesics\tO\n,\tO\nwhereas\tO\nphenacetin\tB-Chemical\nwas\tO\navailable\tO\nonly\tO\nin\tO\ncombinations\tO\n.\tO\n\nThe\tO\npossibility\tO\nthat\tO\nhabitual\tO\nuse\tO\nof\tO\nacetaminophen\tB-Chemical\nalone\tO\nincreases\tO\nthe\tO\nrisk\tO\nof\tO\nESRD\tB-Disease\nhas\tO\nnot\tO\nbeen\tO\nclearly\tO\ndemonstrated\tO\n,\tO\nbut\tO\ncannot\tO\nbe\tO\ndismissed\tO\n.\tO\n\nAcetaminophen\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\n.\tO\n\nThrough\tO\n30\tO\nyears\tO\nof\tO\nwidespread\tO\nuse\tO\n,\tO\nacetaminophen\tB-Chemical\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nbe\tO\na\tO\nremarkably\tO\nsafe\tO\nmedication\tO\nin\tO\ntherapeutic\tO\ndosages\tO\n.\tO\n\nThe\tO\npotential\tO\nfor\tO\nacetaminophen\tB-Chemical\nto\tO\nproduce\tO\ncardiovascular\tB-Disease\ntoxicities\tI-Disease\nis\tO\nvery\tO\nlow\tO\n.\tO\n\nHowever\tO\n,\tO\nacetaminophen\tB-Chemical\nhas\tO\nbeen\tO\ndemonstrated\tO\nto\tO\nproduce\tO\nsymptoms\tO\nof\tO\nanaphylaxis\tB-Disease\n,\tO\nincluding\tO\nhypotension\tB-Disease\n,\tO\nin\tO\nsensitive\tO\nindividuals\tO\n.\tO\n\nThis\tO\narticle\tO\ndescribes\tO\ntwo\tO\ncritically\tB-Disease\nill\tI-Disease\npatients\tO\nin\tO\nwhom\tO\ntransient\tO\nepisodes\tO\nof\tO\nhypotension\tB-Disease\nreproducibly\tO\ndeveloped\tO\nafter\tO\nadministration\tO\nof\tO\nacetaminophen\tB-Chemical\n.\tO\n\nOther\tO\nsymptoms\tO\nof\tO\nallergic\tB-Disease\nreactions\tI-Disease\nwere\tO\nnot\tO\nclinically\tO\ndetectable\tO\n.\tO\n\nThe\tO\nhypotensive\tB-Disease\nepisodes\tO\nwere\tO\nsevere\tO\nenough\tO\nto\tO\nrequire\tO\nvasopressor\tO\nadministration\tO\n.\tO\n\nThe\tO\nreports\tO\nillustrate\tO\nthe\tO\nneed\tO\nfor\tO\nclinicians\tO\nto\tO\nconsider\tO\nacetaminophen\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nhypotension\tB-Disease\nof\tO\nunknown\tO\norigin\tO\n.\tO\n\nReduction\tO\nof\tO\nheparan\tB-Chemical\nsulphate\tI-Chemical\n-\tO\nassociated\tO\nanionic\tO\nsites\tO\nin\tO\nthe\tO\nglomerular\tO\nbasement\tO\nmembrane\tO\nof\tO\nrats\tO\nwith\tO\nstreptozotocin\tB-Chemical\n-\tO\ninduced\tO\ndiabetic\tB-Disease\nnephropathy\tI-Disease\n.\tO\n\nHeparan\tB-Chemical\nsulphate\tI-Chemical\n-\tO\nassociated\tO\nanionic\tO\nsites\tO\nin\tO\nthe\tO\nglomerular\tO\nbasement\tO\nmembrane\tO\nwere\tO\nstudied\tO\nin\tO\nrats\tO\n8\tO\nmonths\tO\nafter\tO\ninduction\tO\nof\tO\ndiabetes\tB-Disease\nby\tO\nstreptozotocin\tB-Chemical\nand\tO\nin\tO\nage\tO\n-\tO\nadn\tO\nsex\tO\n-\tO\nmatched\tO\ncontrol\tO\nrats\tO\n,\tO\nemploying\tO\nthe\tO\ncationic\tO\ndye\tO\ncuprolinic\tB-Chemical\nblue\tI-Chemical\n.\tO\n\nMorphometric\tO\nanalysis\tO\nat\tO\nthe\tO\nultrastructural\tO\nlevel\tO\nwas\tO\nperformed\tO\nusing\tO\na\tO\ncomputerized\tO\nimage\tO\nprocessor\tO\n.\tO\n\nThe\tO\nheparan\tB-Chemical\nsulphate\tI-Chemical\nspecificity\tO\nof\tO\nthe\tO\ncuprolinic\tB-Chemical\nblue\tI-Chemical\nstaining\tO\nwas\tO\ndemonstrated\tO\nby\tO\nglycosaminoglycan\tB-Chemical\n-\tO\ndegrading\tO\nenzymes\tO\n,\tO\nshowing\tO\nthat\tO\npretreatment\tO\nof\tO\nthe\tO\nsections\tO\nwith\tO\nheparitinase\tO\nabolished\tO\nall\tO\nstaining\tO\n,\tO\nwhereas\tO\nchondroitinase\tO\nABC\tO\nhad\tO\nno\tO\neffect\tO\n.\tO\n\nThe\tO\nmajority\tO\nof\tO\nanionic\tO\nsites\tO\n(\tO\n74\tO\n%\tO\nin\tO\ndiabetic\tB-Disease\nand\tO\n81\tO\n%\tO\nin\tO\ncontrol\tO\nrats\tO\n)\tO\nwere\tO\nfound\tO\nwithin\tO\nthe\tO\nlamina\tO\nrara\tO\nexterna\tO\nof\tO\nthe\tO\nglomerular\tO\nbasement\tO\nmembrane\tO\n.\tO\n\nA\tO\nminority\tO\nof\tO\nanionic\tO\nsites\tO\nwere\tO\nscattered\tO\nthroughout\tO\nthe\tO\nlamina\tO\ndensa\tO\nand\tO\nlamina\tO\nrara\tO\ninterna\tO\n,\tO\nand\tO\nwere\tO\nsignificantly\tO\nsmaller\tO\nthan\tO\nthose\tO\nin\tO\nthe\tO\nlamina\tO\nrara\tO\nexterna\tO\nof\tO\nthe\tO\nglomerular\tO\nbasement\tO\nmembrane\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\nand\tO\np\tO\n<\tO\n0\tO\n.\tO\n01\tO\nfor\tO\ndiabetic\tB-Disease\nand\tO\ncontrol\tO\nrats\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nDiabetic\tB-Disease\nrats\tO\nprogressively\tO\ndeveloped\tO\nalbuminuria\tB-Disease\nreaching\tO\n40\tO\n.\tO\n3\tO\n(\tO\n32\tO\n.\tO\n2\tO\n-\tO\n62\tO\n.\tO\n0\tO\n)\tO\nmg\tO\n/\tO\n24\tO\nh\tO\nafter\tO\n8\tO\nmonths\tO\nin\tO\ncontrast\tO\nto\tO\nthe\tO\ncontrol\tO\nanimals\tO\n(\tO\n0\tO\n.\tO\n8\tO\n(\tO\n0\tO\n.\tO\n2\tO\n-\tO\n0\tO\n.\tO\n9\tO\n)\tO\nmg\tO\n/\tO\n24\tO\nh\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n002\tO\n)\tO\n.\tO\n\nAt\tO\nthe\tO\nsame\tO\ntime\tO\n,\tO\nthe\tO\nnumber\tO\nof\tO\nheparan\tB-Chemical\nsulphate\tI-Chemical\nanionic\tO\nsites\tO\nand\tO\nthe\tO\ntotal\tO\nanionic\tO\nsite\tO\nsurface\tO\n(\tO\nnumber\tO\nof\tO\nanionic\tO\nsites\tO\nx\tO\nmean\tO\nanionic\tO\nsite\tO\nsurface\tO\n)\tO\nin\tO\nthe\tO\nlamina\tO\nrara\tO\nexterna\tO\nof\tO\nthe\tO\nglomerular\tO\nbasement\tO\nmembrane\tO\nwas\tO\nreduced\tO\nby\tO\n19\tO\n%\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n021\tO\n)\tO\nand\tO\nby\tO\n26\tO\n%\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n02\tO\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nNumber\tO\nand\tO\ntotal\tO\nanionic\tO\nsite\tO\nsurface\tO\nin\tO\nthe\tO\nremaining\tO\npart\tO\nof\tO\nthe\tO\nglomerular\tO\nbasement\tO\nmembrane\tO\n(\tO\nlamina\tO\ndensa\tO\nand\tO\nlamina\tO\nrara\tO\ninterna\tO\n)\tO\nwere\tO\nnot\tO\nsignificantly\tO\nchanged\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nin\tO\nstreptozotocin\tB-Chemical\n-\tO\ndiabetic\tB-Disease\nrats\tO\nwith\tO\nan\tO\nincreased\tO\nurinary\tO\nalbumin\tO\nexcretion\tO\n,\tO\na\tO\nreduced\tO\nheparan\tB-Chemical\nsulphate\tI-Chemical\ncharge\tO\nbarrier\tO\n/\tO\ndensity\tO\nis\tO\nfound\tO\nat\tO\nthe\tO\nlamina\tO\nrara\tO\nexterna\tO\nof\tO\nthe\tO\nglomerular\tO\nbasement\tO\nmembrane\tO\n.\tO\n\nMediation\tO\nof\tO\nenhanced\tO\nreflex\tO\nvagal\tO\nbradycardia\tB-Disease\nby\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nvia\tO\ncentral\tO\ndopamine\tB-Chemical\nformation\tO\nin\tO\ndogs\tO\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\nDopa\tI-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\ndecreased\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\nafter\tO\nextracerebral\tO\ndecarboxylase\tO\ninhibition\tO\nwith\tO\nMK\tB-Chemical\n-\tI-Chemical\n486\tI-Chemical\n(\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\nin\tO\nanesthetize\tO\nMAO\tB-Chemical\n-\tO\ninhibited\tO\ndogs\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nreflex\tO\nbradycardia\tB-Disease\ncaused\tO\nby\tO\ninjected\tO\nnorepinephrine\tB-Chemical\nwas\tO\nsignificantly\tO\nenhanced\tO\nby\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n,\tO\nDL\tB-Chemical\n-\tI-Chemical\nThreo\tI-Chemical\n-\tI-Chemical\ndihydroxyphenylserine\tI-Chemical\nhad\tO\nno\tO\neffect\tO\non\tO\nblood\tO\npressure\tO\n,\tO\nheart\tO\nrate\tO\nor\tO\nreflex\tO\nresponses\tO\nto\tO\nnorepinephrine\tB-Chemical\n.\tO\n\nFLA\tB-Chemical\n-\tI-Chemical\n63\tI-Chemical\n,\tO\na\tO\ndopamine\tB-Chemical\n-\tO\nbeta\tO\n-\tO\noxidase\tO\ninhibitor\tO\n,\tO\ndid\tO\nnot\tO\nhave\tO\nany\tO\neffect\tO\non\tO\nthe\tO\nhypotension\tB-Disease\n,\tO\nbradycardia\tB-Disease\nor\tO\nreflex\tO\n-\tO\nenhancing\tO\neffect\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\n.\tO\n\nPimozide\tB-Chemical\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nactions\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\non\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\nbut\tO\ncompletely\tO\nblocked\tO\nthe\tO\nenhancement\tO\nof\tO\nreflexes\tO\n.\tO\n\nRemoval\tO\nof\tO\nthe\tO\ncarotid\tO\nsinuses\tO\ncaused\tO\nan\tO\nelevation\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\nand\tO\nabolished\tO\nthe\tO\nnegative\tO\nchronotropic\tO\neffect\tO\nof\tO\nnorepinephrine\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nrestored\tO\nthe\tO\nbradycardia\tB-Disease\ncaused\tO\nby\tO\nnorepinephrine\tB-Chemical\nin\tO\naddition\tO\nto\tO\ndecreasing\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\n.\tO\n\n5\tB-Chemical\n-\tI-Chemical\nHTP\tI-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\nv\tO\n.\tO\n)\tO\ndecreased\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\nand\tO\ndecreased\tO\nthe\tO\nreflex\tO\nbradycardia\tB-Disease\nto\tO\nnorepinephrine\tB-Chemical\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nenhances\tO\nreflex\tO\nbradycardia\tB-Disease\nthrough\tO\ncentral\tO\nalpha\tO\n-\tO\nreceptor\tO\nstimulation\tO\n.\tO\n\nFurthermore\tO\n,\tO\nthe\tO\neffects\tO\nare\tO\nmediated\tO\nthrough\tO\ndopamine\tB-Chemical\nrather\tO\nthan\tO\nnorepinephrine\tB-Chemical\nand\tO\ndo\tO\nnot\tO\nrequire\tO\nthe\tO\ncarotid\tO\nsinus\tO\nbaroreceptors\tO\n.\tO\n\nMicroangiopathic\tB-Disease\nhemolytic\tI-Disease\nanemia\tI-Disease\ncomplicating\tO\nFK506\tB-Chemical\n(\tO\ntacrolimus\tB-Chemical\n)\tO\ntherapy\tO\n.\tO\n\nWe\tO\ndescribe\tO\n3\tO\nepisodes\tO\nof\tO\nmicroangiopathic\tB-Disease\nhemolytic\tI-Disease\nanemia\tI-Disease\n(\tO\nMAHA\tB-Disease\n)\tO\nin\tO\n2\tO\nsolid\tO\norgan\tO\nrecipients\tO\nunder\tO\nFK506\tB-Chemical\n(\tO\ntacrolimus\tB-Chemical\n)\tO\ntherapy\tO\n.\tO\n\nIn\tO\nboth\tO\ncases\tO\n,\tO\ndiscontinuation\tO\nof\tO\nFK506\tB-Chemical\nand\tO\ntreatment\tO\nwith\tO\nplasma\tO\nexchange\tO\n,\tO\nfresh\tO\nfrozen\tO\nplasma\tO\nreplacement\tO\n,\tO\ncorticosteroids\tB-Chemical\n,\tO\naspirin\tB-Chemical\n,\tO\nand\tO\ndipyridamole\tB-Chemical\nled\tO\nto\tO\nresolution\tO\nof\tO\nMAHA\tB-Disease\n.\tO\n\nIn\tO\none\tO\npatient\tO\n,\tO\nreintroduction\tO\nof\tO\nFK506\tB-Chemical\nled\tO\nto\tO\nrapid\tO\nrecurrence\tO\nof\tO\nMAHA\tB-Disease\n.\tO\n\nFK506\tB-Chemical\n-\tO\nassociated\tO\nMAHA\tB-Disease\nis\tO\nprobably\tO\nrare\tO\nbut\tO\nphysicians\tO\nmust\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\nsevere\tO\ncomplication\tO\n.\tO\n\nIn\tO\nour\tO\nexperience\tO\nand\tO\naccording\tO\nto\tO\nthe\tO\nliterature\tO\n,\tO\nFK506\tB-Chemical\ndoes\tO\nnot\tO\nseem\tO\nto\tO\ncross\tO\n-\tO\nreact\tO\nwith\tO\ncyclosporin\tB-Chemical\nA\tI-Chemical\n(\tO\nCyA\tB-Chemical\n)\tO\n,\tO\nan\tO\nimmuno\tO\n-\tO\nsuppressive\tO\ndrug\tO\nalready\tO\nknown\tO\nto\tO\ninduce\tO\nMAHA\tB-Disease\n.\tO\n\nEffect\tO\nof\tO\nsome\tO\nanticancer\tO\ndrugs\tO\nand\tO\ncombined\tO\nchemotherapy\tO\non\tO\nrenal\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nThe\tO\nnephrotoxic\tB-Disease\naction\tO\nof\tO\nanticancer\tO\ndrugs\tO\nsuch\tO\nas\tO\nnitrogranulogen\tB-Chemical\n(\tO\nNG\tB-Chemical\n)\tO\n,\tO\nmethotrexate\tB-Chemical\n(\tO\nMTX\tB-Chemical\n)\tO\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\nand\tO\ncyclophosphamide\tB-Chemical\n(\tO\nCY\tB-Chemical\n)\tO\nadministered\tO\nalone\tO\nor\tO\nin\tO\ncombination\tO\n[\tO\nMTX\tB-Chemical\n+\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n+\tO\nCY\tB-Chemical\n(\tO\nCMF\tO\n)\tO\n]\tO\nwas\tO\nevaluated\tO\nin\tO\nexperiments\tO\non\tO\nWistar\tO\nrats\tO\n.\tO\n\nAfter\tO\ndrug\tO\nadministration\tO\n,\tO\ncreatinine\tB-Chemical\nconcentrations\tO\nin\tO\nthe\tO\nplasma\tO\nand\tO\nin\tO\nthe\tO\nurine\tO\nof\tO\nthe\tO\nrats\tO\nwere\tO\ndetermined\tO\n,\tO\nas\tO\nwell\tO\nas\tO\ncreatinine\tB-Chemical\nclearance\tO\n.\tO\n\nHistopathologic\tO\nevaluation\tO\nof\tO\nthe\tO\nkidneys\tO\nwas\tO\nalso\tO\nperformed\tO\n.\tO\n\nAfter\tO\nMTX\tB-Chemical\nadministration\tO\na\tO\nsignificant\tO\nincrease\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n0228\tO\n)\tO\nin\tO\nthe\tO\nplasma\tO\ncreatinine\tB-Chemical\nconcentration\tO\nand\tO\na\tO\nsignificant\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n0001\tO\n)\tO\ndecrease\tO\nin\tO\ncreatinine\tB-Chemical\nclearance\tO\nwas\tO\nnoted\tO\ncompared\tO\nto\tO\ncontrols\tO\n.\tO\n\nAfter\tO\nthe\tO\nadministration\tO\nof\tO\nNG\tB-Chemical\n,\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nand\tO\nCY\tB-Chemical\nneither\tO\na\tO\nstatistically\tO\nsignificant\tO\nincrease\tO\nin\tO\ncreatinine\tB-Chemical\nconcentration\tO\nnor\tO\nan\tO\nincrease\tO\nin\tO\ncreatinine\tB-Chemical\nclearance\tO\nwas\tO\nobserved\tO\ncompared\tO\nto\tO\nthe\tO\ngroup\tO\nreceiving\tO\nno\tO\ncytostatics\tO\n.\tO\n\nFollowing\tO\npolytherapy\tO\naccording\tO\nto\tO\nthe\tO\nCMF\tO\nregimen\tO\n,\tO\na\tO\nstatistically\tO\nsignificant\tO\ndecrease\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n0343\tO\n)\tO\nin\tO\ncreatinine\tB-Chemical\nclearance\tO\nwas\tO\nfound\tO\n,\tO\nbut\tO\ncreatinine\tB-Chemical\nconcentration\tO\ndid\tO\nnot\tO\nincrease\tO\nsignificantly\tO\ncompared\tO\nto\tO\ncontrols\tO\n.\tO\n\nCY\tB-Chemical\ncaused\tO\nhemorrhagic\tB-Disease\ncystitis\tI-Disease\nin\tO\n40\tO\n%\tO\nof\tO\nrats\tO\n,\tO\nbut\tO\nit\tO\ndid\tO\nnot\tO\ncause\tO\nthis\tO\ncomplication\tO\nwhen\tO\ncombined\tO\nwith\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nand\tO\nMTX\tB-Chemical\n.\tO\n\nHistologic\tO\nchanges\tO\nwere\tO\nfound\tO\nin\tO\nrat\tO\nkidneys\tO\nafter\tO\nadministration\tO\nof\tO\nMTX\tB-Chemical\n,\tO\nCY\tB-Chemical\nand\tO\nNG\tB-Chemical\n,\tO\nwhile\tO\nno\tO\nsuch\tO\nchange\tO\nwas\tO\nobserved\tO\nafter\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nand\tO\njoint\tO\nadministration\tO\nof\tO\nMTX\tB-Chemical\n+\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n+\tO\nCY\tB-Chemical\ncompared\tO\nto\tO\ncontrols\tO\n.\tO\n\nOur\tO\nstudies\tO\nindicate\tO\nthat\tO\nnephrotoxicity\tB-Disease\nof\tO\nMTX\tB-Chemical\n+\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n+\tO\nCY\tB-Chemical\nadministered\tO\njointly\tO\nis\tO\nlower\tO\nthan\tO\nin\tO\nmonotherapy\tO\n.\tO\n\nThe\tO\ninterpeduncular\tO\nnucleus\tO\nregulates\tO\nnicotine\tB-Chemical\n'\tO\ns\tO\neffects\tO\non\tO\nfree\tO\n-\tO\nfield\tO\nactivity\tO\n.\tO\n\nPartial\tO\nlesions\tO\nwere\tO\nmade\tO\nwith\tO\nkainic\tB-Chemical\nacid\tI-Chemical\nin\tO\nthe\tO\ninterpeduncular\tO\nnucleus\tO\nof\tO\nthe\tO\nventral\tO\nmidbrain\tO\nof\tO\nthe\tO\nrat\tO\n.\tO\n\nCompared\tO\nwith\tO\nsham\tO\n-\tO\noperated\tO\ncontrols\tO\n,\tO\nlesions\tO\nsignificantly\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n25\tO\n)\tO\nblunted\tO\nthe\tO\nearly\tO\n(\tO\n<\tO\n60\tO\nmin\tO\n)\tO\nfree\tO\n-\tO\nfield\tO\nlocomotor\tB-Disease\nhypoactivity\tI-Disease\ncaused\tO\nby\tO\nnicotine\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\nkg\tO\n(\tO\n-\tO\n1\tO\n)\tO\n,\tO\ni\tO\n.\tO\nm\tO\n.\tO\n)\tO\n,\tO\nenhanced\tO\nthe\tO\nlater\tO\n(\tO\n60\tO\n-\tO\n120\tO\nmin\tO\n)\tO\nnicotine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\n,\tO\nand\tO\nraised\tO\nspontaneous\tO\nnocturnal\tO\nactivity\tO\n.\tO\n\nLesions\tO\nreduced\tO\nthe\tO\nextent\tO\nof\tO\nimmunohistological\tO\nstaining\tO\nfor\tO\ncholine\tB-Chemical\nacetyltransferase\tO\nin\tO\nthe\tO\ninterpeduncular\tO\nnucleus\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n025\tO\n)\tO\n,\tO\nbut\tO\nnot\tO\nfor\tO\ntyrosine\tB-Chemical\nhydroxylase\tO\nin\tO\nthe\tO\nsurrounding\tO\ncatecholaminergic\tO\nA10\tO\nregion\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nthe\tO\ninterpeduncular\tO\nnucleus\tO\nmediates\tO\nnicotinic\tO\ndepression\tB-Disease\nof\tO\nlocomotor\tO\nactivity\tO\nand\tO\ndampens\tO\nnicotinic\tO\narousal\tO\nmechanisms\tO\nlocated\tO\nelsewhere\tO\nin\tO\nthe\tO\nbrain\tO\n.\tO\n\nLithium\tB-Chemical\n-\tO\nassociated\tO\ncognitive\tB-Disease\nand\tI-Disease\nfunctional\tI-Disease\ndeficits\tI-Disease\nreduced\tO\nby\tO\na\tO\nswitch\tO\nto\tO\ndivalproex\tB-Chemical\nsodium\tI-Chemical\n:\tO\na\tO\ncase\tO\nseries\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nLithium\tB-Chemical\nremains\tO\na\tO\nfirst\tO\n-\tO\nline\tO\ntreatment\tO\nfor\tO\nthe\tO\nacute\tO\nand\tO\nmaintenance\tO\ntreatment\tO\nof\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\n.\tO\n\nAlthough\tO\nmuch\tO\nhas\tO\nbeen\tO\nwritten\tO\nabout\tO\nthe\tO\nmanagement\tO\nof\tO\nthe\tO\nmore\tO\ncommon\tO\nadverse\tO\neffects\tO\nof\tO\nlithium\tB-Chemical\n,\tO\nsuch\tO\nas\tO\npolyuria\tB-Disease\nand\tO\ntremor\tB-Disease\n,\tO\nmore\tO\nsubtle\tO\nlithium\tB-Chemical\nside\tO\neffects\tO\nsuch\tO\nas\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\n,\tO\nloss\tB-Disease\nof\tI-Disease\ncreativity\tI-Disease\n,\tO\nand\tO\nfunctional\tB-Disease\nimpairments\tI-Disease\nremain\tO\nunderstudied\tO\n.\tO\n\nThis\tO\nreport\tO\nsummarizes\tO\nour\tO\nexperience\tO\nin\tO\nswitching\tO\nbipolar\tB-Disease\npatients\tO\nfrom\tO\nlithium\tB-Chemical\nto\tO\ndivalproex\tB-Chemical\nsodium\tI-Chemical\nto\tO\nalleviate\tO\nsuch\tO\ncognitive\tB-Disease\nand\tI-Disease\nfunctional\tI-Disease\nimpairments\tI-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nOpen\tO\n,\tO\ncase\tO\nseries\tO\ndesign\tO\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nreport\tO\nseven\tO\ncases\tO\nwhere\tO\nsubstitution\tO\nof\tO\nlithium\tB-Chemical\n,\tO\neither\tO\nfully\tO\nor\tO\npartially\tO\n,\tO\nwith\tO\ndivalproex\tB-Chemical\nsodium\tI-Chemical\nwas\tO\nextremely\tO\nhelpful\tO\nin\tO\nreducing\tO\nthe\tO\ncognitive\tB-Disease\n,\tI-Disease\nmotivational\tI-Disease\n,\tI-Disease\nor\tI-Disease\ncreative\tI-Disease\ndeficits\tI-Disease\nattributed\tO\nto\tO\nlithium\tB-Chemical\nin\tO\nour\tO\nbipolar\tB-Disease\npatients\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nIn\tO\nthis\tO\npreliminary\tO\nreport\tO\n,\tO\ndivalproex\tB-Chemical\nsodium\tI-Chemical\nwas\tO\na\tO\nsuperior\tO\nalternative\tO\nto\tO\nlithium\tB-Chemical\nin\tO\nbipolar\tB-Disease\npatients\tO\nexperiencing\tO\ncognitive\tB-Disease\ndeficits\tI-Disease\n,\tO\nloss\tB-Disease\nof\tI-Disease\ncreativity\tI-Disease\n,\tO\nand\tO\nfunctional\tB-Disease\nimpairments\tI-Disease\n.\tO\n\nEffect\tO\nof\tO\nnifedipine\tB-Chemical\non\tO\nrenal\tO\nfunction\tO\nin\tO\nliver\tO\ntransplant\tO\nrecipients\tO\nreceiving\tO\ntacrolimus\tB-Chemical\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nnifedipine\tB-Chemical\non\tO\nrenal\tO\nfunction\tO\nin\tO\nliver\tO\ntransplant\tO\nrecipients\tO\nwho\tO\nwere\tO\nreceiving\tO\ntacrolimus\tB-Chemical\nwas\tO\nevaluated\tO\nbetween\tO\nJanuary\tO\n1992\tO\nand\tO\nJanuary\tO\n1996\tO\n.\tO\n\nTwo\tO\ngroups\tO\nof\tO\npatients\tO\nreceiving\tO\ntacrolimus\tB-Chemical\nwere\tO\ncompared\tO\nover\tO\na\tO\nperiod\tO\nof\tO\n1\tO\nyear\tO\n,\tO\none\tO\ngroup\tO\ncomprising\tO\nhypertensive\tB-Disease\npatients\tO\nwho\tO\nwere\tO\nreceiving\tO\nnifedipine\tB-Chemical\n,\tO\nand\tO\nthe\tO\nother\tO\ncomprising\tO\nnonhypertensive\tO\npatients\tO\nnot\tO\nreceiving\tO\nnifedipine\tB-Chemical\n.\tO\n\nThe\tO\ntime\tO\nfrom\tO\ntransplant\tO\nto\tO\nbaseline\tO\nwas\tO\nsimilar\tO\nin\tO\nall\tO\npatients\tO\n.\tO\n\nNifedipine\tB-Chemical\nsignificantly\tO\nimproved\tO\nkidney\tO\nfunction\tO\nas\tO\nindicated\tO\nby\tO\na\tO\nsignificant\tO\nlowering\tO\nof\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\nat\tO\n6\tO\nand\tO\n12\tO\nmonths\tO\n.\tO\n\nThe\tO\nobserved\tO\npositive\tO\nimpact\tO\nof\tO\nnifedipine\tB-Chemical\non\tO\nreducing\tO\nthe\tO\nnephrotoxicity\tB-Disease\nassociated\tO\nwith\tO\ntacrolimus\tB-Chemical\nin\tO\nliver\tO\ntransplant\tO\nrecipients\tO\nshould\tO\nbe\tO\nan\tO\nimportant\tO\nfactor\tO\nin\tO\nselecting\tO\nan\tO\nagent\tO\nto\tO\ntreat\tO\nhypertension\tB-Disease\nin\tO\nthis\tO\npopulation\tO\n.\tO\n\nAlpha\tO\nand\tO\nbeta\tO\ncoma\tB-Disease\nin\tO\ndrug\tO\nintoxication\tO\nuncomplicated\tO\nby\tO\ncerebral\tB-Disease\nhypoxia\tI-Disease\n.\tO\n\nFour\tO\npatients\tO\nwho\tO\nwere\tO\nrendered\tO\ncomatose\tB-Disease\nor\tO\nstuporous\tB-Disease\nby\tO\ndrug\tO\nintoxication\tO\n,\tO\nbut\tO\nwho\tO\nwere\tO\nnot\tO\nhypoxic\tO\n,\tO\nare\tO\ndescribed\tO\n.\tO\n\nThree\tO\npatients\tO\nreceived\tO\nhigh\tO\ndoses\tO\nof\tO\nchlormethiazole\tB-Chemical\nfor\tO\nalcohol\tB-Chemical\nwithdrawal\tB-Disease\nsymptoms\tI-Disease\n,\tO\nand\tO\none\tO\ntook\tO\na\tO\nsuicidal\tO\noverdose\tB-Disease\nof\tO\nnitrazepam\tB-Chemical\n.\tO\n\nThe\tO\npatient\tO\nwith\tO\nnitrazepam\tB-Chemical\noverdose\tB-Disease\nand\tO\ntwo\tO\nof\tO\nthose\tO\nwith\tO\nchlormethiazole\tB-Chemical\nintoxication\tO\nconformed\tO\nto\tO\nthe\tO\ncriteria\tO\nof\tO\n'\tO\nalpha\tO\ncoma\tB-Disease\n'\tO\n,\tO\nshowing\tO\nnon\tO\n-\tO\nreactive\tO\ngeneralized\tO\nor\tO\nfrontally\tO\npredominant\tO\nalpha\tO\nactivity\tO\nin\tO\nthe\tO\nEEG\tO\n.\tO\n\nThe\tO\nfourth\tO\npatient\tO\nwho\tO\nwas\tO\nunconscious\tO\nafter\tO\nchlormethiazole\tB-Chemical\nadministration\tO\nexhibite\tO\ngeneralized\tO\nnon\tO\n-\tO\nreactive\tO\nactivity\tO\nin\tO\nthe\tO\nslow\tO\nbeta\tO\nrange\tO\n.\tO\n\nAll\tO\nfour\tO\nrecovered\tO\ncompletely\tO\nwithout\tO\nneurological\tB-Disease\nsequelae\tI-Disease\nfollowing\tO\nthe\tO\nwithdrawal\tO\nof\tO\nthe\tO\noffending\tO\nagents\tO\n.\tO\n\nThe\tO\nsimilarities\tO\nbetween\tO\nthe\tO\neffects\tO\nof\tO\nstructural\tO\nlesions\tO\nand\tO\npharmacological\tO\ndepression\tB-Disease\nof\tO\nthe\tO\nbrain\tO\nstem\tO\nreticular\tO\nformation\tO\nare\tO\ndiscussed\tO\n.\tO\n\nIt\tO\nis\tO\nsuggested\tO\nthat\tO\nin\tO\nboth\tO\nsituations\tO\ndisturbed\tO\nreticulo\tO\n-\tO\nthalamic\tO\ninteractions\tO\nare\tO\nimportant\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nalpha\tO\ncoma\tB-Disease\n.\tO\n\nIt\tO\nis\tO\nconcluded\tO\nthat\tO\nwhen\tO\nthis\tO\nelectroencephalographic\tO\nand\tO\nbehavioural\tO\npicture\tO\nis\tO\nseen\tO\nin\tO\ndrug\tO\nintoxication\tO\n,\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nsignificant\tO\nhypoxaemia\tB-Disease\n,\tO\na\tO\nfavourable\tO\noutcome\tO\nmay\tO\nbe\tO\nanticipated\tO\n.\tO\n\nMagnetic\tO\nresonance\tO\nvolumetry\tO\nof\tO\nthe\tO\ncerebellum\tO\nin\tO\nepileptic\tB-Disease\npatients\tO\nafter\tO\nphenytoin\tB-Chemical\noverdosages\tB-Disease\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nevaluate\tO\nthe\tO\nrelationship\tO\nbetween\tO\nphenytoin\tB-Chemical\nmedication\tO\nand\tO\ncerebellar\tB-Disease\natrophy\tI-Disease\nin\tO\npatients\tO\nwho\tO\nhad\tO\nexperienced\tO\nclinical\tO\nintoxication\tO\n.\tO\n\nFive\tO\nfemales\tO\nand\tO\n6\tO\nmales\tO\n,\tO\n21\tO\n-\tO\n59\tO\nyears\tO\nof\tO\nage\tO\n,\tO\nwere\tO\nexamined\tO\nwith\tO\na\tO\n1\tO\n.\tO\n5\tO\n-\tO\nT\tO\nwhole\tO\n-\tO\nbody\tO\nsystem\tO\nusing\tO\na\tO\ncircular\tO\npolarized\tO\nhead\tO\ncoil\tO\n.\tO\n\nConventional\tO\nspin\tO\necho\tO\nimages\tO\nwere\tO\nacquired\tO\nin\tO\nthe\tO\nsagittal\tO\nand\tO\ntransverse\tO\norientation\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nwe\tO\nperformed\tO\na\tO\nhigh\tO\n-\tO\nresolution\tO\n3D\tO\ngradient\tO\necho\tO\n,\tO\nT1\tO\n-\tO\nweighted\tO\nsequences\tO\nat\tO\na\tO\n1\tO\n-\tO\nmm\tO\nslice\tO\nthickness\tO\n.\tO\n\nThe\tO\nimages\tO\nwere\tO\nsubsequently\tO\nprocessed\tO\nto\tO\nobtain\tO\nvolumetric\tO\ndata\tO\nfor\tO\nthe\tO\ncerebellum\tO\n.\tO\n\nCerebellar\tO\nvolume\tO\nfor\tO\nthe\tO\npatient\tO\ngroup\tO\nranged\tO\nbetween\tO\n67\tO\n.\tO\n66\tO\nand\tO\n131\tO\n.\tO\n08\tO\nml\tO\n(\tO\nmean\tO\n108\tO\n.\tO\n9\tO\nml\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\n3D\tO\ngradient\tO\necho\tO\ndata\tO\nsets\tO\nfrom\tO\n10\tO\nhealthy\tO\nmale\tO\nand\tO\n10\tO\nhealthy\tO\nfemale\tO\nage\tO\n-\tO\nmatched\tO\nvolunteers\tO\nwere\tO\nused\tO\nto\tO\ncompare\tO\ncerebellar\tO\nvolumes\tO\n.\tO\n\nUsing\tO\nlinear\tO\nregression\tO\nwe\tO\nfound\tO\nthat\tO\nno\tO\ncorrelation\tO\nexists\tO\nbetween\tO\nseizure\tB-Disease\nduration\tO\n,\tO\nelevation\tO\nof\tO\nphenytoin\tB-Chemical\nserum\tO\nlevels\tO\nand\tO\ncerebellar\tO\nvolume\tO\n.\tO\n\nHowever\tO\n,\tO\nmultiple\tO\nregression\tO\nfor\tO\nthe\tO\ndaily\tO\ndosage\tO\n,\tO\nduration\tO\nof\tO\nphenytoin\tB-Chemical\ntreatment\tO\nand\tO\ncerebellar\tO\nvolume\tO\nrevealed\tO\na\tO\ncorrelation\tO\nof\tO\nthese\tO\nparameters\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nphenytoin\tB-Chemical\noverdosage\tB-Disease\ndoes\tO\nnot\tO\nnecessarily\tO\nresult\tO\nin\tO\ncerebellar\tB-Disease\natrophy\tI-Disease\nand\tO\nit\tO\nis\tO\nunlikely\tO\nthat\tO\nphenytoin\tB-Chemical\nmedication\tO\nwas\tO\nthe\tO\nonly\tO\ncause\tO\nof\tO\ncerebellar\tB-Disease\natrophy\tI-Disease\nin\tO\nthe\tO\nremaining\tO\npatients\tO\n.\tO\n\nQuantitative\tO\nmorphometric\tO\nstudies\tO\nof\tO\nthe\tO\ncerebellum\tO\nprovide\tO\nvaluable\tO\ninsights\tO\ninto\tO\nthe\tO\npathogenesis\tO\nof\tO\ncerebellar\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nLate\tO\nrecovery\tO\nof\tO\nrenal\tO\nfunction\tO\nin\tO\na\tO\nwoman\tO\nwith\tO\nthe\tO\nhemolytic\tB-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nA\tO\ncase\tO\nis\tO\nreported\tO\nof\tO\nthe\tO\nhemolytic\tB-Disease\nuremic\tI-Disease\nsyndrome\tI-Disease\n(\tO\nHUS\tB-Disease\n)\tO\nin\tO\na\tO\nwoman\tO\ntaking\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nShe\tO\nwas\tO\ntreated\tO\nwith\tO\nheparin\tB-Chemical\n,\tO\ndipyridamole\tB-Chemical\nand\tO\nhemodialysis\tO\n;\tO\nand\tO\nafter\tO\nmore\tO\nthan\tO\nthree\tO\nmonths\tO\n,\tO\nher\tO\nurinary\tO\noutput\tO\nrose\tO\nabove\tO\n500\tO\nml\tO\n;\tO\nand\tO\nsix\tO\nmonths\tO\nafter\tO\nthe\tO\nonset\tO\nof\tO\nanuria\tB-Disease\n,\tO\ndialysis\tO\ntreatment\tO\nwas\tO\nstopped\tO\n.\tO\n\nThis\tO\ncase\tO\nemphasizes\tO\nthe\tO\npossibility\tO\nthat\tO\nHUS\tB-Disease\nin\tO\nadults\tO\nis\tO\nnot\tO\ninvariably\tO\nirreversible\tO\nand\tO\nthat\tO\n,\tO\ndespite\tO\nprolonged\tO\noliguria\tB-Disease\n,\tO\nrecovery\tO\nof\tO\nrenal\tO\nfunction\tO\ncan\tO\nbe\tO\nobtained\tO\n.\tO\n\nTherefore\tO\n,\tO\nin\tO\nadult\tO\npatients\tO\naffected\tO\nby\tO\nHUS\tB-Disease\n,\tO\ndialysis\tO\nshould\tO\nnot\tO\nbe\tO\ndiscontinued\tO\nprematurely\tO\n;\tO\nmoreover\tO\n,\tO\nbilateral\tO\nnephrectomy\tO\n,\tO\nfor\tO\ntreatment\tO\nof\tO\nsevere\tO\nhypertension\tB-Disease\nand\tO\nmicroangiopathic\tB-Disease\nhemolytic\tI-Disease\nanemia\tI-Disease\n,\tO\nshould\tO\nbe\tO\nperformed\tO\nwith\tO\ncaution\tO\n.\tO\n\nMorphological\tO\nfeatures\tO\nof\tO\nencephalopathy\tB-Disease\nafter\tO\nchronic\tO\nadministration\tO\nof\tO\nthe\tO\nantiepileptic\tO\ndrug\tO\nvalproate\tB-Chemical\nto\tO\nrats\tO\n.\tO\n\nA\tO\ntransmission\tO\nelectron\tO\nmicroscopic\tO\nstudy\tO\nof\tO\ncapillaries\tO\nin\tO\nthe\tO\ncerebellar\tO\ncortex\tO\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nintragastric\tO\napplication\tO\nof\tO\nthe\tO\nantiepileptic\tO\ndrug\tO\nsodium\tB-Chemical\nvalproate\tI-Chemical\n(\tO\nVupral\tO\n\"\tO\nPolfa\tO\n\"\tO\n)\tO\nat\tO\nthe\tO\neffective\tO\ndose\tO\nof\tO\n200\tO\nmg\tO\n/\tO\nkg\tO\nb\tO\n.\tO\n\nw\tO\n.\tO\nonce\tO\ndaily\tO\nto\tO\nrats\tO\nfor\tO\n1\tO\n,\tO\n3\tO\n,\tO\n6\tO\n,\tO\n9\tO\nand\tO\n12\tO\nmonths\tO\nrevealed\tO\nneurological\tB-Disease\ndisorders\tI-Disease\nindicating\tO\ncerebellum\tB-Disease\ndamage\tI-Disease\n(\tO\n\"\tO\nvalproate\tB-Chemical\nencephalopathy\tB-Disease\n\"\tO\n)\tO\n.\tO\n\nThe\tO\nfirst\tO\nultrastructural\tO\nchanges\tO\nin\tO\nstructural\tO\nelements\tO\nof\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\n-\tO\nbarrier\tO\n(\tO\nBBB\tO\n)\tO\nin\tO\nthe\tO\ncerebellar\tO\ncortex\tO\nwere\tO\ndetectable\tO\nafter\tO\n3\tO\nmonths\tO\nof\tO\nthe\tO\nexperiment\tO\n.\tO\n\nThey\tO\nbecame\tO\nmore\tO\nsevere\tO\nin\tO\nthe\tO\nlater\tO\nmonths\tO\nof\tO\nthe\tO\nexperiment\tO\n,\tO\nand\tO\nwere\tO\nmost\tO\nsevere\tO\nafter\tO\n12\tO\nmonths\tO\n,\tO\nlocated\tO\nmainly\tO\nin\tO\nthe\tO\nmolecular\tO\nlayer\tO\nof\tO\nthe\tO\ncerebellar\tO\ncortex\tO\n.\tO\n\nLesions\tO\nof\tO\nthe\tO\ncapillary\tO\nincluded\tO\nnecrosis\tB-Disease\nof\tO\nendothelial\tO\ncells\tO\n.\tO\n\nOrganelles\tO\nof\tO\nthese\tO\ncells\tO\n,\tO\nin\tO\nparticular\tO\nthe\tO\nmitochondria\tO\n(\tO\nincreased\tO\nnumber\tO\nand\tO\nsize\tO\n,\tO\ndistinct\tO\ndegeneration\tO\nof\tO\ntheir\tO\nmatrix\tO\nand\tO\ncristae\tO\n)\tO\nand\tO\nGolgi\tO\napparatus\tO\nwere\tO\naltered\tO\n.\tO\n\nReduced\tO\nsize\tO\nof\tO\ncapillary\tO\nlumen\tO\nand\tO\nocclusion\tO\nwere\tO\ncaused\tO\nby\tO\nswollen\tO\nendothelial\tO\ncells\tO\nwhich\tO\nhad\tO\nluminal\tB-Chemical\nprotrusions\tO\nand\tO\nswollen\tO\nmicrovilli\tO\n.\tO\n\nPressure\tO\non\tO\nthe\tO\nvessel\tO\nwall\tO\nwas\tO\nproduced\tO\nby\tO\nenlarged\tO\nperivascular\tO\nastrocytic\tO\nprocesses\tO\n.\tO\n\nFragments\tO\nof\tO\nnecrotic\tB-Disease\nendothelial\tO\ncells\tO\nwere\tO\nin\tO\nthe\tO\nvascular\tO\nlumens\tO\nand\tO\nin\tO\nthese\tO\nthere\tO\nwas\tO\nloosening\tO\nand\tO\nbreaking\tO\nof\tO\ntight\tO\ncellular\tO\njunctions\tO\n.\tO\n\nDamage\tO\nto\tO\nthe\tO\nvascular\tO\nbasement\tO\nlamina\tO\nwas\tO\nalso\tO\nobserved\tO\n.\tO\n\nDamage\tO\nto\tO\nthe\tO\ncapillary\tO\nwas\tO\naccompanied\tO\nby\tO\nmarked\tO\ndamage\tO\nto\tO\nneuroglial\tO\ncells\tO\n,\tO\nmainly\tO\nto\tO\nperivascular\tO\nprocesses\tO\nof\tO\nastrocytes\tO\n.\tO\n\nThe\tO\nproliferation\tO\nof\tO\nastrocytes\tO\n(\tO\nBergmann\tO\n'\tO\ns\tO\nin\tO\nparticular\tO\n)\tO\nand\tO\noccasionally\tO\nof\tO\noligodendrocytes\tO\nwas\tO\nfound\tO\n.\tO\n\nAlterations\tO\nin\tO\nthe\tO\nstructural\tO\nelements\tO\nof\tO\nthe\tO\nBBB\tO\ncoexisted\tO\nwith\tO\nmarked\tO\nlesions\tO\nof\tO\nneurons\tO\nof\tO\nthe\tO\ncerebellum\tO\n(\tO\nPurkinje\tO\ncells\tO\nare\tO\nearliest\tO\n)\tO\n.\tO\n\nIn\tO\nelectron\tO\nmicrographs\tO\nboth\tO\nluminal\tB-Chemical\nand\tO\nantiluminal\tO\nsides\tO\nof\tO\nthe\tO\nBBB\tO\nof\tO\nthe\tO\ncerebellar\tO\ncortex\tO\nhad\tO\nsimilar\tO\nlesions\tO\n.\tO\n\nThe\tO\npossible\tO\ninfluence\tO\nof\tO\nthe\tO\nhepatic\tB-Disease\ndamage\tI-Disease\n,\tO\nmainly\tO\nhyperammonemia\tB-Disease\n,\tO\nupon\tO\nthe\tO\ndevelopment\tO\nof\tO\nvalproate\tB-Chemical\nencephalopathy\tB-Disease\nis\tO\ndiscussed\tO\n.\tO\n\nFatal\tO\nintracranial\tB-Disease\nbleeding\tI-Disease\nassociated\tO\nwith\tO\nprehospital\tO\nuse\tO\nof\tO\nepinephrine\tB-Chemical\n.\tO\n\nWe\tO\npresent\tO\na\tO\ncase\tO\nof\tO\nparamedic\tO\nmisjudgment\tO\nin\tO\nthe\tO\nexecution\tO\nof\tO\na\tO\nprotocol\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nallergic\tB-Disease\nreaction\tI-Disease\nin\tO\na\tO\ncase\tO\nof\tO\npulmonary\tB-Disease\nedema\tI-Disease\nwith\tO\nwheezing\tB-Disease\n.\tO\n\nThe\tO\nsudden\tO\nonset\tO\nof\tO\nrespiratory\tB-Disease\ndistress\tI-Disease\n,\tO\nrash\tB-Disease\n,\tO\nand\tO\na\tO\nhistory\tO\nof\tO\na\tO\nnew\tO\nmedicine\tO\nled\tO\nthe\tO\ntwo\tO\nparamedics\tO\non\tO\nthe\tO\nscene\tO\nto\tO\nadminister\tO\nsubcutaneous\tO\nepinephrine\tB-Chemical\n.\tO\n\nSubsequently\tO\n,\tO\nacute\tO\ncardiac\tB-Disease\narrest\tI-Disease\nand\tO\nfatal\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\noccurred\tO\n.\tO\n\nEpinephrine\tB-Chemical\nhas\tO\na\tO\nproven\tO\nrole\tO\nin\tO\ncardiac\tB-Disease\narrest\tI-Disease\nin\tO\nprehospital\tO\ncare\tO\n;\tO\nhowever\tO\n,\tO\nuse\tO\nby\tO\nparamedics\tO\nin\tO\npatients\tO\nwith\tO\nsuspected\tO\nallergic\tB-Disease\nreaction\tI-Disease\nand\tO\nsevere\tO\nhypertension\tB-Disease\nshould\tO\nbe\tO\nviewed\tO\nwith\tO\ncaution\tO\n.\tO\n\nRole\tO\nof\tO\nactivation\tO\nof\tO\nbradykinin\tB-Chemical\nB2\tO\nreceptors\tO\nin\tO\ndisruption\tO\nof\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\nduring\tO\nacute\tO\nhypertension\tB-Disease\n.\tO\n\nCellular\tO\nmechanisms\tO\nwhich\tO\naccount\tO\nfor\tO\ndisruption\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\nduring\tO\nacute\tO\nhypertension\tB-Disease\nare\tO\nnot\tO\nclear\tO\n.\tO\n\nThe\tO\ngoal\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\nrole\tO\nof\tO\nsynthesis\tO\n/\tO\nrelease\tO\nof\tO\nbradykinin\tB-Chemical\nto\tO\nactivate\tO\nB2\tO\nreceptors\tO\nin\tO\ndisruption\tO\nof\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\nduring\tO\nacute\tO\nhypertension\tB-Disease\n.\tO\n\nPermeability\tO\nof\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\nwas\tO\nquantitated\tO\nby\tO\nclearance\tO\nof\tO\nfluorescent\tO\n-\tO\nlabeled\tO\ndextran\tB-Chemical\nbefore\tO\nand\tO\nduring\tO\nphenylephrine\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\nhypertension\tB-Disease\nin\tO\nrats\tO\ntreated\tO\nwith\tO\nvehicle\tO\nand\tO\nHoe\tB-Chemical\n-\tI-Chemical\n140\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\nmicroM\tO\n)\tO\n.\tO\n\nPhenylephrine\tB-Chemical\ninfusion\tO\nincreased\tO\narterial\tO\npressure\tO\n,\tO\narteriolar\tO\ndiameter\tO\nand\tO\nclearance\tO\nof\tO\nfluorescent\tO\ndextran\tB-Chemical\nby\tO\na\tO\nsimilar\tO\nmagnitude\tO\nin\tO\nboth\tO\ngroups\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\ndisruption\tO\nof\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\nduring\tO\nacute\tO\nhypertension\tB-Disease\nis\tO\nnot\tO\nrelated\tO\nto\tO\nthe\tO\nsynthesis\tO\n/\tO\nrelease\tO\nof\tO\nbradykinin\tB-Chemical\nto\tO\nactivate\tO\nB2\tO\nreceptors\tO\n.\tO\n\nRisk\tO\nfactors\tO\nof\tO\nsensorineural\tB-Disease\nhearing\tI-Disease\nloss\tI-Disease\nin\tO\npreterm\tO\ninfants\tO\n.\tO\n\nAmong\tO\n547\tO\npreterm\tO\ninfants\tO\nof\tO\n<\tO\nor\tO\n=\tO\n34\tO\nweeks\tO\ngestation\tO\nborn\tO\nbetween\tO\n1987\tO\nand\tO\n1991\tO\n,\tO\n8\tO\nchildren\tO\n(\tO\n1\tO\n.\tO\n46\tO\n%\tO\n)\tO\ndeveloped\tO\nsevere\tO\nprogressive\tO\nand\tO\nbilateral\tO\nsensorineural\tB-Disease\nhearing\tI-Disease\nloss\tI-Disease\n.\tO\n\nPerinatal\tO\nrisk\tO\nfactors\tO\nof\tO\ninfants\tO\nwith\tO\nhearing\tB-Disease\nloss\tI-Disease\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nof\tO\ntwo\tO\ncontrol\tO\ngroups\tO\nmatched\tO\nfor\tO\ngestation\tO\nand\tO\nbirth\tO\nweight\tO\nand\tO\nfor\tO\nperinatal\tO\ncomplications\tO\n.\tO\n\nOur\tO\nobservations\tO\ndemonstrated\tO\nan\tO\nassociation\tO\nof\tO\nhearing\tB-Disease\nloss\tI-Disease\nwith\tO\na\tO\nhigher\tO\nincidence\tO\nof\tO\nperinatal\tO\ncomplications\tO\n.\tO\n\nOtotoxicity\tB-Disease\nappeared\tO\nclosely\tO\nrelated\tO\nto\tO\na\tO\nprolonged\tO\nadministration\tO\nand\tO\nhigher\tO\ntotal\tO\ndose\tO\nof\tO\nototoxic\tB-Disease\ndrugs\tO\n,\tO\nparticularly\tO\naminoglycosides\tB-Chemical\nand\tO\nfurosemide\tB-Chemical\n.\tO\n\nFinally\tO\n,\tO\nwe\tO\nstrongly\tO\nrecommend\tO\nto\tO\nprospectively\tO\nand\tO\nregularly\tO\nperform\tO\naudiologic\tO\nassessment\tO\nin\tO\nsick\tO\npreterm\tO\nchildren\tO\nas\tO\nhearing\tB-Disease\nloss\tI-Disease\nis\tO\nof\tO\ndelayed\tO\nonset\tO\nand\tO\nin\tO\nmost\tO\ncases\tO\nbilateral\tO\nand\tO\nsevere\tO\n.\tO\n\nSeizure\tB-Disease\nresulting\tO\nfrom\tO\na\tO\nvenlafaxine\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nvenlafaxine\tB-Chemical\noverdose\tB-Disease\n.\tO\n\nCASE\tO\nSUMMARY\tO\n:\tO\nA\tO\n40\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nmajor\tB-Disease\ndepression\tI-Disease\ntook\tO\nan\tO\noverdose\tB-Disease\nof\tO\nvenlafaxine\tB-Chemical\nin\tO\nan\tO\napparent\tO\nsuicide\tO\nattempt\tO\n.\tO\n\nAfter\tO\nthe\tO\ningestion\tO\nof\tO\n26\tO\nvenlafaxine\tB-Chemical\n50\tO\n-\tO\nmg\tO\ntablets\tO\n,\tO\nthe\tO\npatient\tO\nexperienced\tO\na\tO\nwitnessed\tO\ngeneralized\tO\nseizure\tB-Disease\n.\tO\n\nShe\tO\nwas\tO\nadmitted\tO\nto\tO\nthe\tO\nmedical\tO\nintensive\tO\ncare\tO\nunit\tO\n,\tO\nvenlafaxine\tB-Chemical\nwas\tO\ndiscontinued\tO\n,\tO\nand\tO\nno\tO\nfurther\tO\nsequelae\tO\nwere\tO\nseen\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nTo\tO\nour\tO\nknowledge\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nfirst\tO\nreported\tO\ncase\tO\nof\tO\nvenlafaxine\tB-Chemical\noverdose\tB-Disease\nthat\tO\nresulted\tO\nin\tO\na\tO\ngeneralized\tO\nseizure\tB-Disease\n.\tO\n\nBased\tO\non\tO\nnonoverdose\tO\npharmacokinetics\tO\nand\tO\npharmacodynamics\tO\nof\tO\nvenlafaxine\tB-Chemical\nand\tO\nthe\tO\npotential\tO\nrisks\tO\nof\tO\navailable\tO\ninterventions\tO\n,\tO\nno\tO\nemergent\tO\ntherapy\tO\nwas\tO\ninstituted\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nvenlafaxine\tB-Chemical\noverdose\tB-Disease\nin\tO\nour\tO\npatient\tO\nresulted\tO\nin\tO\na\tO\nsingle\tO\nepisode\tO\nof\tO\ngeneralized\tO\nseizure\tB-Disease\nbut\tO\nelicited\tO\nno\tO\nfurther\tO\nsequelae\tO\n.\tO\n\nCombined\tO\neffects\tO\nof\tO\nprolonged\tO\nprostaglandin\tB-Chemical\nE1\tI-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nand\tO\nhaemodilution\tB-Disease\non\tO\nhuman\tO\nhepatic\tO\nfunction\tO\n.\tO\n\nCombined\tO\neffects\tO\nof\tO\nprolonged\tO\nprostaglandin\tB-Chemical\nE1\tI-Chemical\n(\tO\nPGE1\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nhypotension\tB-Disease\nand\tO\nhaemodilution\tB-Disease\non\tO\nhepatic\tO\nfunction\tO\nwere\tO\nstudied\tO\nin\tO\n30\tO\npatients\tO\nundergoing\tO\nhip\tO\nsurgery\tO\n.\tO\n\nThe\tO\npatients\tO\nwere\tO\nrandomly\tO\nallocated\tO\nto\tO\none\tO\nof\tO\nthree\tO\ngroups\tO\n;\tO\nthose\tO\nin\tO\ngroup\tO\nA\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\nwere\tO\nsubjected\tO\nto\tO\ncontrolled\tO\nhypotension\tB-Disease\nalone\tO\n,\tO\nthose\tO\nin\tO\ngroup\tO\nB\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\nto\tO\nhaemodilution\tB-Disease\nalone\tO\nand\tO\nthose\tO\nin\tO\ngroup\tO\nC\tO\n(\tO\nn\tO\n=\tO\n10\tO\n)\tO\nto\tO\nboth\tO\ncontrolled\tO\nhypotension\tB-Disease\nand\tO\nhaemodilution\tB-Disease\n.\tO\n\nHaemodilution\tB-Disease\nin\tO\ngroups\tO\nB\tO\nand\tO\nC\tO\nwas\tO\nproduced\tO\nby\tO\nwithdrawing\tO\napproximately\tO\n1000\tO\nmL\tO\nof\tO\nblood\tO\nand\tO\nreplacing\tO\nit\tO\nwith\tO\nthe\tO\nsame\tO\namount\tO\nof\tO\ndextran\tB-Chemical\nsolution\tO\n,\tO\nand\tO\nfinal\tO\nhaematocrit\tO\nvalues\tO\nwere\tO\n21\tO\nor\tO\n22\tO\n%\tO\n.\tO\n\nControlled\tO\nhypotension\tB-Disease\nin\tO\ngroups\tO\nA\tO\nand\tO\nC\tO\nwas\tO\ninduced\tO\nwith\tO\nPGE1\tB-Chemical\nto\tO\nmaintain\tO\nmean\tO\narterial\tO\nblood\tO\npressure\tO\nat\tO\n55\tO\nmmHg\tO\nfor\tO\n180\tO\nmin\tO\n.\tO\n\nMeasurements\tO\nincluded\tO\narterial\tO\nketone\tO\nbody\tO\nratio\tO\n(\tO\nAKBR\tO\n,\tO\naceto\tB-Chemical\n-\tI-Chemical\nacetate\tI-Chemical\n/\tO\n3\tB-Chemical\n-\tI-Chemical\nhydroxybutyrate\tI-Chemical\n)\tO\nand\tO\nclinical\tO\nhepatic\tO\nfunction\tO\nparameters\tO\n.\tO\n\nAKBR\tO\nand\tO\nbiological\tO\nhepatic\tO\nfunction\tO\ntests\tO\nshowed\tO\nno\tO\nchange\tO\nthroughout\tO\nthe\tO\ntime\tO\ncourse\tO\nin\tO\ngroups\tO\nA\tO\nand\tO\nB\tO\n.\tO\n\nIn\tO\ngroup\tO\nC\tO\n,\tO\nAKBR\tO\nshowed\tO\na\tO\nsignificant\tO\ndecrease\tO\nat\tO\n120\tO\nmin\tO\n(\tO\n-\tO\n40\tO\n%\tO\n)\tO\nand\tO\nat\tO\n180\tO\nmin\tO\n(\tO\n-\tO\n49\tO\n%\tO\n)\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\nhypotension\tB-Disease\nand\tO\nat\tO\n60\tO\nmin\tO\n(\tO\n-\tO\n32\tO\n%\tO\n)\tO\nafter\tO\nrecovery\tO\nof\tO\nnormotension\tO\n,\tO\nand\tO\nSGOT\tO\n,\tO\nSGPT\tO\n,\tO\nLDH\tO\nand\tO\ntotal\tO\nbilirubin\tB-Chemical\nshowed\tO\nsignificant\tO\nincreases\tO\nafter\tO\noperation\tO\n.\tO\n\nThe\tO\nresults\tO\nsuggest\tO\nthat\tO\na\tO\nprolonged\tO\ncombination\tO\nof\tO\nmore\tO\nthan\tO\n120\tO\nmin\tO\nof\tO\nPGE1\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nand\tO\nmoderate\tO\nhaemodilution\tB-Disease\nwould\tO\ncause\tO\nimpairment\tB-Disease\nof\tI-Disease\nhepatic\tI-Disease\nfunction\tI-Disease\n.\tO\n\nCardiovascular\tB-Disease\nalterations\tI-Disease\nin\tO\nrat\tO\nfetuses\tO\nexposed\tO\nto\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\n.\tO\n\nPreclinical\tO\ntoxicologic\tO\ninvestigation\tO\nsuggested\tO\nthat\tO\na\tO\nnew\tO\ncalcium\tB-Chemical\nchannel\tO\nblocker\tO\n,\tO\nRo\tB-Chemical\n40\tI-Chemical\n-\tI-Chemical\n5967\tI-Chemical\n,\tO\ninduced\tO\ncardiovascular\tB-Disease\nalterations\tI-Disease\nin\tO\nrat\tO\nfetuses\tO\nexposed\tO\nto\tO\nthis\tO\nagent\tO\nduring\tO\norganogenesis\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\ninvestigate\tO\nthe\tO\nhypothesis\tO\nthat\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\nin\tO\ngeneral\tO\ninduce\tO\ncardiovascular\tB-Disease\nmalformations\tI-Disease\nindicating\tO\na\tO\npharmacologic\tO\nclass\tO\neffect\tO\n.\tO\n\nWe\tO\nstudied\tO\nthree\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\nof\tO\ndifferent\tO\nstructure\tO\n,\tO\nnifedipine\tB-Chemical\n,\tO\ndiltiazem\tB-Chemical\n,\tO\nand\tO\nverapamil\tB-Chemical\n,\tO\nalong\tO\nwith\tO\nthe\tO\nnew\tO\nagent\tO\n.\tO\n\nPregnant\tO\nrats\tO\nwere\tO\nadministered\tO\none\tO\nof\tO\nthese\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\nduring\tO\nthe\tO\nperiod\tO\nof\tO\ncardiac\tO\nmorphogenesis\tO\nand\tO\nthe\tO\noffspring\tO\nexamined\tO\non\tO\nday\tO\n20\tO\nof\tO\ngestation\tO\nfor\tO\ncardiovascular\tB-Disease\nmalformations\tI-Disease\n.\tO\n\nA\tO\nlow\tO\nincidence\tO\nof\tO\ncardiovascular\tB-Disease\nmalformations\tI-Disease\nwas\tO\nobserved\tO\nafter\tO\nexposure\tO\nto\tO\neach\tO\nof\tO\nthe\tO\nfour\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\n,\tO\nbut\tO\nthis\tO\nincidence\tO\nwas\tO\nstatistically\tO\nsignificant\tO\nonly\tO\nfor\tO\nverapamil\tB-Chemical\nand\tO\nnifedipine\tB-Chemical\n.\tO\n\nAll\tO\nfour\tO\nagents\tO\nwere\tO\nassociated\tO\nwith\tO\naortic\tO\narch\tO\nbranching\tO\nvariants\tO\n,\tO\nalthough\tO\nsignificantly\tO\nincreased\tO\nonly\tO\nfor\tO\nRo\tB-Chemical\n40\tI-Chemical\n-\tI-Chemical\n5967\tI-Chemical\nand\tO\nverapamil\tB-Chemical\n.\tO\n\nThe\tO\nsite\tO\nof\tO\ncommon\tO\nside\tO\neffects\tO\nof\tO\nsumatriptan\tB-Chemical\n.\tO\n\nAtypical\tB-Disease\nsensations\tI-Disease\nfollowing\tO\nthe\tO\nuse\tO\nof\tO\nsubcutaneous\tO\nsumatriptan\tB-Chemical\nare\tO\ncommon\tO\n,\tO\nbut\tO\nof\tO\nuncertain\tO\norigin\tO\n.\tO\n\nThey\tO\nare\tO\nalmost\tO\nalways\tO\nbenign\tO\n,\tO\nbut\tO\ncan\tO\nbe\tO\nmistaken\tO\nfor\tO\na\tO\nserious\tO\nadverse\tO\nevent\tO\nby\tO\nthe\tO\npatient\tO\n.\tO\n\nTwo\tO\npatients\tO\nare\tO\npresented\tO\nwith\tO\ntingling\tB-Disease\nor\tI-Disease\nburning\tI-Disease\nsensations\tI-Disease\nlimited\tO\nto\tO\nareas\tO\nof\tO\nheat\tO\nexposure\tO\nor\tO\nsunburn\tB-Disease\n.\tO\n\nIn\tO\nthese\tO\nindividuals\tO\n,\tO\nside\tO\neffects\tO\nare\tO\nmost\tO\nlikely\tO\ngenerated\tO\nsuperficially\tO\nin\tO\nthe\tO\nskin\tO\n.\tO\n\nMacula\tO\ntoxicity\tB-Disease\nafter\tO\nintravitreal\tO\namikacin\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nAlthough\tO\nintravitreal\tO\naminoglycosides\tB-Chemical\nhave\tO\nsubstantially\tO\nimproved\tO\nvisual\tO\nprognosis\tO\nin\tO\nendophthalmitis\tB-Disease\n,\tO\nmacular\tO\ninfarction\tB-Disease\nmay\tO\nimpair\tO\nfull\tO\nvisual\tO\nrecovery\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\npresent\tO\na\tO\ncase\tO\nof\tO\npresumed\tO\namikacin\tB-Chemical\nretinal\tB-Disease\ntoxicity\tI-Disease\nfollowing\tO\ntreatment\tO\nwith\tO\namikacin\tB-Chemical\nand\tO\nvancomycin\tB-Chemical\nfor\tO\nalpha\tO\n-\tO\nhaemolytic\tO\nstreptococcal\tB-Disease\nendophthalmitis\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nEndophthalmitis\tB-Disease\nresolved\tO\nwith\tO\nimprovement\tO\nin\tO\nvisual\tO\nacuity\tO\nto\tO\n6\tO\n/\tO\n24\tO\nat\tO\nthree\tO\nmonths\tO\n.\tO\n\nFundus\tO\nfluorescein\tB-Chemical\nangiography\tO\nconfirmed\tO\nmacular\tO\ncapillary\tO\nclosure\tO\nand\tO\ntelangiectasis\tB-Disease\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCurrently\tO\naccepted\tO\nintravitreal\tO\nantibiotic\tO\nregimens\tO\nmay\tO\ncause\tO\nretinal\tB-Disease\ntoxicity\tI-Disease\nand\tO\nmacular\tO\nischaemia\tB-Disease\n.\tO\n\nTreatment\tO\nstrategies\tO\naimed\tO\nat\tO\navoiding\tO\nretinal\tB-Disease\ntoxicity\tI-Disease\nare\tO\ndiscussed\tO\n.\tO\n\nThe\tO\nrole\tO\nof\tO\nnicotine\tB-Chemical\nin\tO\nsmoking\tO\n-\tO\nrelated\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n.\tO\n\nNicotine\tB-Chemical\nactivates\tO\nthe\tO\nsympathetic\tO\nnervous\tO\nsystem\tO\nand\tO\nin\tO\nthis\tO\nway\tO\ncould\tO\ncontribute\tO\nto\tO\ncardiovascular\tB-Disease\ndisease\tI-Disease\n.\tO\n\nAnimal\tO\nstudies\tO\nand\tO\nmechanistic\tO\nstudies\tO\nindicate\tO\nthat\tO\nnicotine\tB-Chemical\ncould\tO\nplay\tO\na\tO\nrole\tO\nin\tO\naccelerating\tO\natherosclerosis\tB-Disease\n,\tO\nbut\tO\nevidence\tO\namong\tO\nhumans\tO\nis\tO\ntoo\tO\ninadequate\tO\nto\tO\nbe\tO\ndefinitive\tO\nabout\tO\nsuch\tO\nan\tO\neffect\tO\n.\tO\n\nAlmost\tO\ncertainly\tO\n,\tO\nnicotine\tB-Chemical\nvia\tO\nits\tO\nhemodynamic\tO\neffects\tO\ncontributes\tO\nto\tO\nacute\tO\ncardiovascular\tO\nevents\tO\n,\tO\nalthough\tO\ncurrent\tO\nevidence\tO\nsuggests\tO\nthat\tO\nthe\tO\neffects\tO\nof\tO\nnicotine\tB-Chemical\nare\tO\nmuch\tO\nless\tO\nimportant\tO\nthan\tO\nare\tO\nthe\tO\nprothrombotic\tO\neffects\tO\nof\tO\ncigarette\tO\nsmoking\tO\nor\tO\nthe\tO\neffects\tO\nof\tO\ncarbon\tB-Chemical\nmonoxide\tI-Chemical\n.\tO\n\nNicotine\tB-Chemical\ndoes\tO\nnot\tO\nappear\tO\nto\tO\nenhance\tO\nthrombosis\tB-Disease\namong\tO\nhumans\tO\n.\tO\n\nClinical\tO\nstudies\tO\nof\tO\npipe\tO\nsmokers\tO\nand\tO\npeople\tO\nusing\tO\ntransdermal\tO\nnicotine\tB-Chemical\nsupport\tO\nthe\tO\nidea\tO\nthat\tO\ntoxins\tO\nother\tO\nthan\tO\nnicotine\tB-Chemical\nare\tO\nthe\tO\nmost\tO\nimportant\tO\ncauses\tO\nof\tO\nacute\tO\ncardiovascular\tO\nevents\tO\n.\tO\n\nFinally\tO\n,\tO\nthe\tO\ndose\tO\nresponse\tO\nfor\tO\ncardiovascular\tO\nevents\tO\nof\tO\nnicotine\tB-Chemical\nappears\tO\nto\tO\nbe\tO\nflat\tO\n,\tO\nsuggesting\tO\nthat\tO\nif\tO\nnicotine\tB-Chemical\nis\tO\ninvolved\tO\n,\tO\nadverse\tO\neffects\tO\nmight\tO\nbe\tO\nseen\tO\nwith\tO\nrelatively\tO\nlow\tO\n-\tO\nlevel\tO\ncigarette\tO\nexposures\tO\n.\tO\n\nIatrogenically\tO\ninduced\tO\nintractable\tO\natrioventricular\tB-Disease\nreentrant\tI-Disease\ntachycardia\tI-Disease\nafter\tO\nverapamil\tB-Chemical\nand\tO\ncatheter\tO\nablation\tO\nin\tO\na\tO\npatient\tO\nwith\tO\nWolff\tB-Disease\n-\tI-Disease\nParkinson\tI-Disease\n-\tI-Disease\nWhite\tI-Disease\nsyndrome\tI-Disease\nand\tO\nidiopathic\tB-Disease\ndilated\tI-Disease\ncardiomyopathy\tI-Disease\n.\tO\n\nIn\tO\na\tO\npatient\tO\nwith\tO\nWPW\tB-Disease\nsyndrome\tI-Disease\nand\tO\nidiopathic\tB-Disease\ndilated\tI-Disease\ncardiomyopathy\tI-Disease\n,\tO\nintractable\tO\natrioventricular\tB-Disease\nreentrant\tI-Disease\ntachycardia\tI-Disease\n(\tO\nAVRT\tB-Disease\n)\tO\nwas\tO\niatrogenically\tO\ninduced\tO\n.\tO\n\nQRS\tO\nwithout\tO\npreexcitation\tO\n,\tO\ncaused\tO\nby\tO\njunctional\tO\nescape\tO\nbeats\tO\nafter\tO\nverapamil\tB-Chemical\nor\tO\nunidirectional\tO\nantegrade\tO\nblock\tO\nof\tO\naccessory\tO\npathway\tO\nafter\tO\ncatheter\tO\nablation\tO\n,\tO\nestablished\tO\nfrequent\tO\nAVRT\tB-Disease\nattack\tO\n.\tO\n\nEpidemic\tO\nof\tO\nliver\tB-Disease\ndisease\tI-Disease\ncaused\tO\nby\tO\nhydrochlorofluorocarbons\tB-Chemical\nused\tO\nas\tO\nozone\tB-Chemical\n-\tO\nsparing\tO\nsubstitutes\tO\nof\tO\nchlorofluorocarbons\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nHydrochlorofluorocarbons\tB-Chemical\n(\tO\nHCFCs\tB-Chemical\n)\tO\nare\tO\nused\tO\nincreasingly\tO\nin\tO\nindustry\tO\nas\tO\nsubstitutes\tO\nfor\tO\nozone\tB-Chemical\n-\tO\ndepleting\tO\nchlorofluorocarbons\tB-Chemical\n(\tO\nCFCs\tB-Chemical\n)\tO\n.\tO\n\nLimited\tO\nstudies\tO\nin\tO\nanimals\tO\nindicate\tO\npotential\tO\nhepatotoxicity\tB-Disease\nof\tO\nsome\tO\nof\tO\nthese\tO\ncompounds\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nan\tO\nepidemic\tO\nof\tO\nliver\tB-Disease\ndisease\tI-Disease\nin\tO\nnine\tO\nindustrial\tO\nworkers\tO\nwho\tO\nhad\tO\nhad\tO\nrepeated\tO\naccidental\tO\nexposure\tO\nto\tO\na\tO\nmixture\tO\nof\tO\n1\tB-Chemical\n,\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\ndichloro\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ntrifluoroethane\tI-Chemical\n(\tO\nHCFC\tB-Chemical\n123\tI-Chemical\n)\tO\nand\tO\n1\tB-Chemical\n-\tI-Chemical\nchloro\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ntetrafluoroethane\tI-Chemical\n(\tO\nHCFC\tB-Chemical\n124\tI-Chemical\n)\tO\n.\tO\n\nAll\tO\nnine\tO\nexposed\tO\nworkers\tO\nwere\tO\naffected\tO\nto\tO\nvarious\tO\ndegrees\tO\n.\tO\n\nBoth\tO\ncompounds\tO\nare\tO\nmetabolised\tO\nin\tO\nthe\tO\nsame\tO\nway\tO\nas\tO\n1\tB-Chemical\n-\tI-Chemical\nbromo\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nchloro\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n,\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ntrifluoroethane\tI-Chemical\n(\tO\nhalothane\tB-Chemical\n)\tO\nto\tO\nform\tO\nreactive\tO\ntrifluoroacetyl\tB-Chemical\nhalide\tO\nintermediates\tO\n,\tO\nwhich\tO\nhave\tO\nbeen\tO\nimplicated\tO\nin\tO\nthe\tO\nhepatotoxicity\tB-Disease\nof\tO\nhalothane\tB-Chemical\n.\tO\n\nWe\tO\naimed\tO\nto\tO\ntest\tO\nwhether\tO\nHCFCs\tB-Chemical\n123\tI-Chemical\nand\tI-Chemical\n124\tI-Chemical\ncan\tO\nresult\tO\nin\tO\nserious\tO\nliver\tB-Disease\ndisease\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nFor\tO\none\tO\nseverely\tO\naffected\tO\nworker\tO\nliver\tO\nbiopsy\tO\nand\tO\nimmunohistochemical\tO\nstainings\tO\nfor\tO\nthe\tO\npresence\tO\nof\tO\ntrifluoroacetyl\tB-Chemical\nprotein\tO\nadducts\tO\nwere\tO\ndone\tO\n.\tO\n\nThe\tO\nserum\tO\nof\tO\nsix\tO\naffected\tO\nworkers\tO\nand\tO\nfive\tO\ncontrols\tO\nwas\tO\ntested\tO\nfor\tO\nautoantibodies\tO\nthat\tO\nreact\tO\nwith\tO\nhuman\tO\nliver\tO\ncytochrome\tO\n-\tO\nP450\tO\n2E1\tO\n(\tO\nP450\tO\n2E1\tO\n)\tO\nand\tO\nP58\tO\nprotein\tO\ndisulphide\tO\nisomerase\tO\nisoform\tO\n(\tO\nP58\tO\n)\tO\n.\tO\n\nFINDINGS\tO\n:\tO\nThe\tO\nliver\tO\nbiopsy\tO\nsample\tO\nshowed\tO\nhepatocellular\tO\nnecrosis\tB-Disease\nwhich\tO\nwas\tO\nprominent\tO\nin\tO\nperivenular\tO\nzone\tO\nthree\tO\nand\tO\nextended\tO\nfocally\tO\nfrom\tO\nportal\tO\ntracts\tO\nto\tO\nportal\tO\ntracts\tO\nand\tO\ncentrilobular\tO\nareas\tO\n(\tO\nbridging\tO\nnecrosis\tB-Disease\n)\tO\n.\tO\n\nTrifluoroacetyl\tB-Chemical\n-\tO\nadducted\tO\nproteins\tO\nwere\tO\ndetected\tO\nin\tO\nsurviving\tO\nhepatocytes\tO\n.\tO\n\nAutoantibodies\tO\nagainst\tO\nP450\tO\n2E1\tO\nor\tO\nP58\tO\n,\tO\npreviously\tO\nassociated\tO\nwith\tO\nhalothane\tB-Disease\nhepatitis\tI-Disease\n,\tO\nwere\tO\ndetected\tO\nin\tO\nthe\tO\nserum\tO\nof\tO\nfive\tO\naffected\tO\nworkers\tO\n.\tO\n\nINTERPRETATION\tO\n:\tO\nRepeated\tO\nexposure\tO\nof\tO\nhuman\tO\nbeings\tO\nto\tO\nHCFCs\tB-Chemical\n123\tI-Chemical\nand\tI-Chemical\n124\tI-Chemical\ncan\tO\nresult\tO\nin\tO\nserious\tO\nliver\tB-Disease\ninjury\tI-Disease\nin\tO\na\tO\nlarge\tO\nproportion\tO\nof\tO\nthe\tO\nexposed\tO\npopulation\tO\n.\tO\n\nAlthough\tO\nthe\tO\nexact\tO\nmechanism\tO\nof\tO\nhepatotoxicity\tB-Disease\nof\tO\nthese\tO\nagents\tO\nis\tO\nnot\tO\nknown\tO\n,\tO\nthe\tO\nresults\tO\nsuggest\tO\nthat\tO\ntrifluoroacetyl\tB-Chemical\n-\tO\naltered\tO\nliver\tO\nproteins\tO\nare\tO\ninvolved\tO\n.\tO\n\nIn\tO\nview\tO\nof\tO\nthe\tO\npotentially\tO\nwidespread\tO\nuse\tO\nof\tO\nthese\tO\ncompounds\tO\n,\tO\nthere\tO\nis\tO\nan\tO\nurgent\tO\nneed\tO\nto\tO\ndevelop\tO\nsafer\tO\nalternatives\tO\n.\tO\n\nBile\tB-Disease\nduct\tI-Disease\nhamartoma\tI-Disease\noccurring\tO\nin\tO\nassociation\tO\nwith\tO\nlong\tO\n-\tO\nterm\tO\ntreatment\tO\nwith\tO\ndanazol\tB-Chemical\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nbile\tB-Disease\nduct\tI-Disease\nhamartoma\tI-Disease\nwhich\tO\ndeveloped\tO\nin\tO\na\tO\npatient\tO\nwho\tO\nhad\tO\nbeen\tO\non\tO\nlong\tO\n-\tO\nterm\tO\ndanazol\tB-Chemical\ntreatment\tO\n.\tO\n\nSuch\tO\npatients\tO\nshould\tO\nbe\tO\nunder\tO\nclose\tO\nfollow\tO\n-\tO\nup\tO\n,\tO\npreferably\tO\nwith\tO\nperiodic\tO\nultrasound\tO\nexamination\tO\nof\tO\nthe\tO\nliver\tO\n.\tO\n\nIf\tO\nthe\tO\npatient\tO\ndevelops\tO\na\tO\nliver\tB-Disease\nmass\tI-Disease\n,\tO\nbecause\tO\nof\tO\nnon\tO\n-\tO\nspecific\tO\nclinical\tO\nfeatures\tO\nand\tO\nimaging\tO\nappearances\tO\n,\tO\nbiopsy\tO\nmay\tO\nbe\tO\nthe\tO\nonly\tO\nway\tO\nto\tO\nachieve\tO\na\tO\ndefinitive\tO\ndiagnosis\tO\n.\tO\n\nEndocrine\tO\nscreening\tO\nin\tO\n1\tO\n,\tO\n022\tO\nmen\tO\nwith\tO\nerectile\tB-Disease\ndysfunction\tI-Disease\n:\tO\nclinical\tO\nsignificance\tO\nand\tO\ncost\tO\n-\tO\neffective\tO\nstrategy\tO\n.\tO\n\nPURPOSE\tO\n:\tO\nWe\tO\nreviewed\tO\nthe\tO\nresults\tO\nof\tO\nserum\tO\ntestosterone\tB-Chemical\nand\tO\nprolactin\tO\ndetermination\tO\nin\tO\n1\tO\n,\tO\n022\tO\npatients\tO\nreferred\tO\nbecause\tO\nof\tO\nerectile\tB-Disease\ndysfunction\tI-Disease\nand\tO\ncompared\tO\nthe\tO\ndata\tO\nwith\tO\nhistory\tO\n,\tO\nresults\tO\nof\tO\nphysical\tO\nexamination\tO\n,\tO\nother\tO\netiological\tO\ninvestigations\tO\nand\tO\neffects\tO\nof\tO\nendocrine\tO\ntherapy\tO\nto\tO\nrefine\tO\nthe\tO\nrules\tO\nof\tO\ncost\tO\n-\tO\neffective\tO\nendocrine\tO\nscreening\tO\nand\tO\nto\tO\npinpoint\tO\nactual\tO\nresponsibility\tO\nfor\tO\nhormonal\tO\nabnormalities\tO\n.\tO\n\nMATERIALS\tO\nAND\tO\nMETHODS\tO\n:\tO\nTestosterone\tB-Chemical\nand\tO\nprolactin\tO\nwere\tO\ndetermined\tO\nby\tO\nradioimmunoassay\tO\n.\tO\n\nEvery\tO\npatient\tO\nwas\tO\nscreened\tO\nfor\tO\ntestosterone\tB-Chemical\nand\tO\n451\tO\nwere\tO\nscreened\tO\nfor\tO\nprolactin\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\nlow\tB-Disease\nsexual\tI-Disease\ndesire\tI-Disease\n,\tO\ngynecomastia\tB-Disease\nor\tO\ntestosterone\tB-Chemical\nless\tO\nthan\tO\n4\tO\nng\tO\n.\tO\n/\tO\nml\tO\n.\tO\n\nDetermination\tO\nwas\tO\nrepeated\tO\nin\tO\ncase\tO\nof\tO\nabnormal\tO\nfirst\tO\nresults\tO\n.\tO\n\nProlactin\tO\nresults\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nof\tO\na\tO\nprevious\tO\npersonal\tO\ncohort\tO\nof\tO\n1\tO\n,\tO\n340\tO\npatients\tO\nwith\tO\nerectile\tB-Disease\ndysfunction\tI-Disease\nand\tO\nsystematic\tO\nprolactin\tO\ndetermination\tO\n.\tO\n\nMain\tO\nclinical\tO\ncriteria\tO\ntested\tO\nregarding\tO\nefficiency\tO\nin\tO\nhormone\tO\ndetermination\tO\nwere\tO\nlow\tB-Disease\nsexual\tI-Disease\ndesire\tI-Disease\n,\tO\nsmall\tO\ntestes\tO\nand\tO\ngynecomastia\tB-Disease\n.\tO\n\nEndocrine\tO\ntherapy\tO\nconsisted\tO\nof\tO\ntestosterone\tB-Chemical\nheptylate\tI-Chemical\nor\tO\nhuman\tO\nchorionic\tO\ngonadotropin\tO\nfor\tO\nhypogonadism\tB-Disease\nand\tO\nbromocriptine\tB-Chemical\nfor\tO\nhyperprolactinemia\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nTestosterone\tB-Chemical\nwas\tO\nless\tO\nthan\tO\n3\tO\nng\tO\n.\tO\n/\tO\nml\tO\n.\tO\nin\tO\n107\tO\npatients\tO\nbut\tO\nnormal\tO\nin\tO\n40\tO\n%\tO\nat\tO\nrepeat\tO\ndetermination\tO\n.\tO\n\nThe\tO\nprevalence\tO\nof\tO\nrepeatedly\tO\nlow\tO\ntestosterone\tB-Chemical\nincreased\tO\nwith\tO\nage\tO\n(\tO\n4\tO\n%\tO\nbefore\tO\nage\tO\n50\tO\nyears\tO\nand\tO\n9\tO\n%\tO\n50\tO\nyears\tO\nor\tO\nolder\tO\n)\tO\n.\tO\n\nTwo\tO\npituitary\tB-Disease\ntumors\tI-Disease\nwere\tO\ndiscovered\tO\nafter\tO\ntestosterone\tB-Chemical\ndetermination\tO\n.\tO\n\nMost\tO\nof\tO\nthe\tO\nother\tO\nlow\tO\ntestosterone\tB-Chemical\nlevels\tO\nseemed\tO\nto\tO\nresult\tO\nfrom\tO\nnonorganic\tO\nhypothalamic\tB-Disease\ndysfunction\tI-Disease\nbecause\tO\nof\tO\nnormal\tO\nserum\tO\nluteinizing\tO\nhormone\tO\nand\tO\nprolactin\tO\nand\tO\nto\tO\nhave\tO\nonly\tO\na\tO\nsmall\tO\nrole\tO\nin\tO\nerectile\tB-Disease\ndysfunction\tI-Disease\n(\tO\ndefinite\tO\nimprovement\tO\nin\tO\nonly\tO\n16\tO\nof\tO\n44\tO\n[\tO\n36\tO\n%\tO\n]\tO\nafter\tO\nandrogen\tO\ntherapy\tO\n,\tO\nnormal\tO\nmorning\tO\nor\tO\nnocturnal\tO\nerections\tO\nin\tO\n30\tO\n%\tO\nand\tO\ndefinite\tO\nvasculogenic\tO\ncontributions\tO\nin\tO\n42\tO\n%\tO\n)\tO\n.\tO\n\nDetermining\tO\ntestosterone\tB-Chemical\nonly\tO\nin\tO\ncases\tO\nof\tO\nlow\tB-Disease\nsexual\tI-Disease\ndesire\tI-Disease\nor\tO\nabnormal\tO\nphysical\tO\nexamination\tO\nwould\tO\nhave\tO\nmissed\tO\n40\tO\n%\tO\nof\tO\nthe\tO\ncases\tO\nwith\tO\nlow\tO\ntestosterone\tB-Chemical\n,\tO\nincluding\tO\n37\tO\n%\tO\nof\tO\nthose\tO\nsubsequently\tO\nimproved\tO\nby\tO\nandrogen\tO\ntherapy\tO\n.\tO\n\nProlactin\tO\nexceeded\tO\n20\tO\nng\tO\n.\tO\n/\tO\nml\tO\n.\tO\nin\tO\n5\tO\nmen\tO\nand\tO\nwas\tO\nnormal\tO\nin\tO\n2\tO\nat\tO\nrepeat\tO\ndetermination\tO\n.\tO\n\nOnly\tO\n1\tO\nprolactinoma\tB-Disease\nwas\tO\ndiscovered\tO\n.\tO\n\nThese\tO\ndata\tO\nare\tO\nlower\tO\nthan\tO\nthose\tO\nwe\tO\nfound\tO\nduring\tO\nthe\tO\nlast\tO\n2\tO\ndecades\tO\n(\tO\noverall\tO\nprolactin\tO\ngreater\tO\nthan\tO\n20\tO\nng\tO\n.\tO\n/\tO\nml\tO\n.\tO\nin\tO\n1\tO\n.\tO\n86\tO\n%\tO\nof\tO\n1\tO\n,\tO\n821\tO\npatients\tO\n,\tO\nprolactinomas\tB-Disease\nin\tO\n7\tO\n,\tO\n0\tO\n.\tO\n38\tO\n%\tO\n)\tO\n.\tO\n\nBromocriptine\tB-Chemical\nwas\tO\ndefinitely\tO\neffective\tO\nin\tO\ncases\tO\nwith\tO\nprolactin\tO\ngreater\tO\nthan\tO\n35\tO\nng\tO\n.\tO\n/\tO\nml\tO\n.\tO\n\n(\tO\n8\tO\nof\tO\n12\tO\ncompared\tO\nto\tO\nonly\tO\n9\tO\nof\tO\n22\tO\ncases\tO\nwith\tO\nprolactin\tO\nbetween\tO\n20\tO\nand\tO\n35\tO\nng\tO\n.\tO\n/\tO\nml\tO\n.\tO\n)\tO\n.\tO\n\nTestosterone\tB-Chemical\nwas\tO\nlow\tO\nin\tO\nless\tO\nthan\tO\n50\tO\n%\tO\nof\tO\ncases\tO\nwith\tO\nprolactin\tO\ngreater\tO\nthan\tO\n35\tO\nng\tO\n.\tO\n/\tO\nml\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nLow\tO\nprevalences\tO\nand\tO\neffects\tO\nof\tO\nlow\tO\ntestosterone\tB-Chemical\nand\tO\nhigh\tO\nprolactin\tO\nin\tO\nerectile\tB-Disease\ndysfunction\tI-Disease\ncannot\tO\njustify\tO\ntheir\tO\nroutine\tO\ndetermination\tO\n.\tO\n\nHowever\tO\n,\tO\ncost\tO\n-\tO\neffective\tO\nscreening\tO\nstrategies\tO\nrecommended\tO\nso\tO\nfar\tO\nmissed\tO\n40\tO\nto\tO\n50\tO\n%\tO\nof\tO\ncases\tO\nimproved\tO\nwith\tO\nendocrine\tO\ntherapy\tO\nand\tO\nthe\tO\npituitary\tB-Disease\ntumors\tI-Disease\n.\tO\n\nWe\tO\nnow\tO\nadvocate\tO\nthat\tO\nbefore\tO\nage\tO\n50\tO\nyears\tO\ntestosterone\tB-Chemical\nbe\tO\ndetermined\tO\nonly\tO\nin\tO\ncases\tO\nof\tO\nlow\tB-Disease\nsexual\tI-Disease\ndesire\tI-Disease\nand\tO\nabnormal\tO\nphysical\tO\nexamination\tO\nbut\tO\nthat\tO\nit\tO\nbe\tO\nmeasured\tO\nin\tO\nall\tO\nmen\tO\nolder\tO\nthan\tO\n50\tO\nyears\tO\n.\tO\n\nProlactin\tO\nshould\tO\nbe\tO\ndetermined\tO\nonly\tO\nin\tO\ncases\tO\nof\tO\nlow\tB-Disease\nsexual\tI-Disease\ndesire\tI-Disease\n,\tO\ngynecomastia\tB-Disease\nand\tO\n/\tO\nor\tO\ntestosterone\tB-Chemical\nless\tO\nthan\tO\n4\tO\nng\tO\n.\tO\n/\tO\nml\tO\n.\tO\n\nExtrapyramidal\tO\nside\tO\neffects\tO\nwith\tO\nrisperidone\tB-Chemical\nand\tO\nhaloperidol\tB-Chemical\nat\tO\ncomparable\tO\nD2\tO\nreceptor\tO\noccupancy\tO\nlevels\tO\n.\tO\n\nRisperidone\tB-Chemical\nis\tO\nan\tO\nantipsychotic\tO\ndrug\tO\nwith\tO\nhigh\tO\naffinity\tO\nat\tO\ndopamine\tB-Chemical\nD2\tO\nand\tO\nserotonin\tB-Chemical\n5\tI-Chemical\n-\tI-Chemical\nHT2\tI-Chemical\nreceptors\tO\n.\tO\n\nPrevious\tO\nclinical\tO\nstudies\tO\nhave\tO\nproposed\tO\nthat\tO\nrisperidone\tB-Chemical\n'\tO\ns\tO\npharmacologic\tO\nprofile\tO\nmay\tO\nproduce\tO\nimproved\tO\nefficacy\tO\nfor\tO\nnegative\tO\npsychotic\tB-Disease\nsymptoms\tI-Disease\nand\tO\ndecreased\tO\npropensity\tO\nfor\tO\nextrapyramidal\tO\nside\tO\neffects\tO\n;\tO\nfeatures\tO\nshared\tO\nby\tO\nso\tO\n-\tO\ncalled\tO\n'\tO\natypical\tO\n'\tO\nneuroleptics\tO\n.\tO\n\nTo\tO\ndetermine\tO\nif\tO\nroutine\tO\nrisperidone\tB-Chemical\ntreatment\tO\nis\tO\nassociated\tO\nwith\tO\na\tO\nunique\tO\ndegree\tO\nof\tO\nD2\tO\nreceptor\tO\noccupancy\tO\nand\tO\npattern\tO\nof\tO\nclinical\tO\neffects\tO\n,\tO\nwe\tO\nused\tO\n[\tO\n123I\tO\n]\tO\nIBZM\tO\nSPECT\tO\nto\tO\ndetermine\tO\nD2\tO\noccupancy\tO\nin\tO\nsubjects\tO\ntreated\tO\nwith\tO\nroutine\tO\nclinical\tO\ndoses\tO\nof\tO\nrisperidone\tB-Chemical\n(\tO\nn\tO\n=\tO\n12\tO\n)\tO\nor\tO\nhaloperidol\tB-Chemical\n(\tO\nn\tO\n=\tO\n7\tO\n)\tO\n.\tO\n\nBoth\tO\nrisperidone\tB-Chemical\nand\tO\nhaloperidol\tB-Chemical\nproduced\tO\nD2\tO\noccupancy\tO\nlevels\tO\nbetween\tO\napproximately\tO\n60\tO\nand\tO\n90\tO\n%\tO\nat\tO\nstandard\tO\nclinical\tO\ndoses\tO\n.\tO\n\nThere\tO\nwas\tO\nno\tO\nsignificant\tO\ndifference\tO\nbetween\tO\noccupancy\tO\nlevels\tO\nobtained\tO\nwith\tO\nhaloperidol\tB-Chemical\nor\tO\nrisperidone\tB-Chemical\n.\tO\n\nDrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nparkinsonism\tI-Disease\nwas\tO\nobserved\tO\nin\tO\nsubjects\tO\ntreated\tO\nwith\tO\nrisperidone\tB-Chemical\n(\tO\n42\tO\n%\tO\n)\tO\nand\tO\nhaloperidol\tB-Chemical\n(\tO\n29\tO\n%\tO\n)\tO\nand\tO\nwas\tO\nobserved\tO\nat\tO\noccupancy\tO\nlevels\tO\nabove\tO\n60\tO\n%\tO\n.\tO\n\nBased\tO\non\tO\nthese\tO\nobservations\tO\n,\tO\nit\tO\nis\tO\nconcluded\tO\nthat\tO\n5\tO\n-\tO\nHT2\tO\nblockade\tO\nobtained\tO\nwith\tO\nrisperidone\tB-Chemical\nat\tO\nD2\tO\noccupancy\tO\nrates\tO\nof\tO\n60\tO\n%\tO\nand\tO\nabove\tO\ndoes\tO\nnot\tO\nappear\tO\nto\tO\nprotect\tO\nagainst\tO\nthe\tO\nrisk\tO\nfor\tO\nextrapyramidal\tO\nside\tO\neffects\tO\n.\tO\n\nTreatment\tO\nof\tO\npreviously\tO\ntreated\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\nby\tO\nmitoxantrone\tB-Chemical\nand\tO\n48\tO\n-\tO\nhour\tO\ncontinuous\tO\ninfusion\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\nand\tO\nleucovorin\tB-Chemical\n(\tO\nMFL\tB-Chemical\n)\tO\n:\tO\nlow\tO\npalliative\tO\nbenefit\tO\nand\tO\nhigh\tO\ntreatment\tO\n-\tO\nrelated\tO\ntoxicity\tB-Disease\n.\tO\n\nFor\tO\npreviously\tO\ntreated\tO\nadvanced\tO\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\nthere\tO\nis\tO\nno\tO\nstandard\tO\nsecond\tO\n-\tO\nline\tO\ntherapy\tO\n.\tO\n\nCombination\tO\nchemotherapy\tO\nwith\tO\nmitoxantrone\tB-Chemical\n,\tO\nhigh\tO\n-\tO\ndose\tO\n5\tB-Chemical\n-\tI-Chemical\nfluorouracil\tI-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n)\tO\nand\tO\nleucovorin\tB-Chemical\n(\tO\nMFL\tB-Chemical\nregimen\tI-Chemical\n)\tO\nhad\tO\nbeen\tO\nreported\tO\nas\tO\nan\tO\neffective\tO\nand\tO\nwell\tO\ntolerated\tO\nregimen\tO\n.\tO\n\nFrom\tO\nOctober\tO\n1993\tO\nto\tO\nNovember\tO\n1995\tO\n,\tO\nwe\tO\ntreated\tO\n13\tO\npatients\tO\nwith\tO\npreviously\tO\nchemotherapy\tO\n-\tO\ntreated\tO\nmetastatic\tO\nbreast\tB-Disease\ncancer\tI-Disease\nby\tO\nmitoxantrone\tB-Chemical\n,\tO\n12\tO\nmg\tO\n/\tO\nm2\tO\n,\tO\non\tO\nday\tO\n1\tO\nand\tO\ncontinuous\tO\ninfusion\tO\nof\tO\n5\tB-Chemical\n-\tI-Chemical\nFU\tI-Chemical\n,\tO\n3000\tO\nmg\tO\n/\tO\nm2\tO\n,\tO\ntogether\tO\nwith\tO\nleucovorin\tB-Chemical\n,\tO\n300\tO\nmg\tO\n/\tO\nm2\tO\n,\tO\nfor\tO\n48\tO\nh\tO\nfrom\tO\nday\tO\n1\tO\nto\tO\n2\tO\n.\tO\n\nEach\tO\ncourse\tO\nof\tO\nchemotherapy\tO\nwas\tO\ngiven\tO\nevery\tO\n4\tO\nweeks\tO\n.\tO\n\nMost\tO\nof\tO\nthese\tO\npatients\tO\nhad\tO\nmore\tO\nthan\tO\ntwo\tO\nmetastatic\tO\nsites\tO\n,\tO\nwith\tO\nlung\tO\nmetastasis\tO\npredominant\tO\n.\tO\n\nSeven\tO\npatients\tO\nhad\tO\nbeen\tO\ntreated\tO\nwith\tO\nanthracycline\tB-Chemical\n.\tO\n\nSeven\tO\npatients\tO\nhad\tO\npreviously\tO\nreceived\tO\nradiotherapy\tO\nand\tO\nseven\tO\nhad\tO\nreceived\tO\nhormone\tO\ntherapy\tO\n.\tO\n\nMedian\tO\nnumber\tO\nof\tO\ncourses\tO\nof\tO\nMFL\tB-Chemical\nregimen\tI-Chemical\ngiven\tO\nwas\tO\nsix\tO\nand\tO\nthe\tO\nmedian\tO\ncumulative\tO\ndose\tO\nof\tO\nmitoxantrone\tB-Chemical\nwas\tO\n68\tO\n.\tO\n35\tO\nmg\tO\n/\tO\nm2\tO\n.\tO\n\nOne\tO\npatient\tO\nhad\tO\ncomplete\tO\nresponse\tO\n,\tO\nseven\tO\nhad\tO\nstable\tO\ndisease\tO\n,\tO\nnone\tO\nhad\tO\npartial\tO\nresponse\tO\nand\tO\nfive\tO\nhad\tO\nprogressive\tO\ndisease\tO\n.\tO\n\nThe\tO\noverall\tO\nobjective\tO\nresponse\tO\nrate\tO\nwas\tO\n7\tO\n.\tO\n6\tO\n%\tO\n.\tO\n\nThe\tO\nmedian\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\nwas\tO\n14\tO\nmonths\tO\n.\tO\n\nMedian\tO\nsurvival\tO\nwas\tO\n16\tO\nmonths\tO\n.\tO\n\nMedian\tO\nprogression\tO\n-\tO\nfree\tO\nsurvival\tO\nwas\tO\n5\tO\nmonths\tO\n.\tO\n\nA\tO\ncomplete\tO\nresponder\tO\nhad\tO\nrelapse\tO\n-\tO\nfree\tO\nsurvival\tO\nup\tO\nto\tO\n17\tO\nmonths\tO\n.\tO\n\nMajor\tO\ntoxicities\tB-Disease\nwere\tO\ncardiotoxicity\tB-Disease\nand\tO\nleukopenia\tB-Disease\n.\tO\n\nEight\tO\npatients\tO\nwere\tO\ndead\tO\nin\tO\nthe\tO\nlast\tO\nfollow\tO\n-\tO\nup\tO\n;\tO\ntwo\tO\nof\tO\nthem\tO\ndied\tO\nof\tO\ntreatment\tO\n-\tO\nrelated\tO\ntoxicity\tB-Disease\n.\tO\n\nThe\tO\nMFL\tB-Chemical\nregimen\tI-Chemical\nachieves\tO\nlittle\tO\npalliative\tO\nbenefit\tO\nand\tO\ninduces\tO\nsevere\tO\ntoxicity\tB-Disease\nat\tO\na\tO\nfairly\tO\nhigh\tO\nrate\tO\n.\tO\n\nAdministration\tO\nof\tO\nthis\tO\nregimen\tO\nto\tO\nbreast\tB-Disease\ncancer\tI-Disease\npatients\tO\nwho\tO\nhave\tO\nbeen\tO\ntreated\tO\nby\tO\nchemotherapy\tO\nand\tO\nthose\tO\nwith\tO\nimpaired\tB-Disease\nheart\tI-Disease\nfunction\tI-Disease\nrequires\tO\ncareful\tO\nattention\tO\n.\tO\n\nTiclopidine\tB-Chemical\n-\tO\ninduced\tO\naplastic\tB-Disease\nanemia\tI-Disease\n:\tO\nreport\tO\nof\tO\nthree\tO\nChinese\tO\npatients\tO\nand\tO\nreview\tO\nof\tO\nthe\tO\nliterature\tO\n.\tO\n\nIn\tO\nthis\tO\nstudy\tO\n,\tO\nthree\tO\nChinese\tO\npatients\tO\nwith\tO\nticlopidine\tB-Chemical\n-\tO\ninduced\tO\naplastic\tB-Disease\nanemia\tI-Disease\nwere\tO\nreported\tO\nand\tO\nanother\tO\n13\tO\npatients\tO\nin\tO\nthe\tO\nEnglish\tO\nliterature\tO\nwere\tO\nreviewed\tO\n.\tO\n\nWe\tO\nattempted\tO\nto\tO\nfind\tO\nunderlying\tO\nsimilarities\tO\n,\tO\nevaluate\tO\nthe\tO\nrisk\tO\nfactors\tO\n,\tO\nand\tO\nidentify\tO\nappropriate\tO\ntreatment\tO\nfor\tO\nthis\tO\ncomplication\tO\n.\tO\n\nAll\tO\nbut\tO\none\tO\nof\tO\nthe\tO\npatients\tO\nwere\tO\nover\tO\n60\tO\nyears\tO\nold\tO\n,\tO\nand\tO\nthe\tO\n6\tO\nwho\tO\ndied\tO\nwere\tO\nall\tO\nolder\tO\nthan\tO\n65\tO\n.\tO\n\nTherefore\tO\n,\tO\nold\tO\nage\tO\nmay\tO\nbe\tO\na\tO\nrisk\tO\nfactor\tO\nfor\tO\ndeveloping\tO\nthis\tO\ncomplication\tO\n.\tO\n\nAgranulocytosis\tB-Disease\noccurred\tO\n3\tO\n-\tO\n20\tO\nweeks\tO\nafter\tO\ninitiation\tO\nof\tO\nticlopidine\tB-Chemical\n,\tO\nso\tO\nfrequent\tO\nexamination\tO\nof\tO\nwhite\tO\ncell\tO\ncount\tO\nduring\tO\ntreatment\tO\nis\tO\nrecommended\tO\n.\tO\n\nThere\tO\nseemed\tO\nto\tO\nbe\tO\nno\tO\ndirect\tO\ncorrelation\tO\nbetween\tO\nthe\tO\ndose\tO\nor\tO\nduration\tO\nused\tO\nand\tO\nthe\tO\nseverity\tO\nof\tO\nbone\tB-Disease\nmarrow\tI-Disease\nsuppression\tI-Disease\n.\tO\n\nTreatment\tO\nfor\tO\nticlopidine\tB-Chemical\n-\tO\ninduced\tO\naplastic\tB-Disease\nanemia\tI-Disease\nwith\tO\ncolony\tO\n-\tO\nstimulating\tO\nfactors\tO\nseemed\tO\nto\tO\nhave\tO\nlittle\tO\neffect\tO\n.\tO\n\nThe\tO\nfact\tO\nthat\tO\n5\tO\nof\tO\nthe\tO\n6\tO\npatients\tO\nwho\tO\nreceived\tO\nconcurrent\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\ndied\tO\n,\tO\nshould\tO\nalert\tO\nclinicians\tO\nto\tO\nbe\tO\nmore\tO\ncautious\tO\nwhen\tO\nusing\tO\nthese\tO\ntwo\tO\ndrugs\tO\nsimultaneously\tO\n.\tO\n\nUpregulation\tO\nof\tO\nthe\tO\nexpression\tO\nof\tO\nvasopressin\tB-Chemical\ngene\tO\nin\tO\nthe\tO\nparaventricular\tO\nand\tO\nsupraoptic\tO\nnuclei\tO\nof\tO\nthe\tO\nlithium\tB-Chemical\n-\tO\ninduced\tO\ndiabetes\tB-Disease\ninsipidus\tI-Disease\nrat\tO\n.\tO\n\nThe\tO\nexpression\tO\nof\tO\narginine\tB-Chemical\nvasopressin\tI-Chemical\n(\tO\nAVP\tB-Chemical\n)\tO\ngene\tO\nin\tO\nthe\tO\nparaventricular\tO\n(\tO\nPVN\tO\n)\tO\nand\tO\nsupraoptic\tO\nnuclei\tO\n(\tO\nSON\tO\n)\tO\nwas\tO\ninvestigated\tO\nin\tO\nrats\tO\nwith\tO\nlithium\tB-Chemical\n(\tO\nLi\tB-Chemical\n)\tO\n-\tO\ninduced\tO\npolyuria\tB-Disease\n,\tO\nusing\tO\nin\tO\nsitu\tO\nhybridization\tO\nhistochemistry\tO\nand\tO\nradioimmunoassay\tO\n.\tO\n\nThe\tO\nmale\tO\nWistar\tO\nrats\tO\nconsuming\tO\na\tO\ndiet\tO\nthat\tO\ncontained\tO\nLiCl\tB-Chemical\n(\tO\n60\tO\nmmol\tO\n/\tO\nkg\tO\n)\tO\nfor\tO\n4\tO\nweeks\tO\ndeveloped\tO\nmarked\tO\npolyuria\tB-Disease\n.\tO\n\nThe\tO\nLi\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nproduced\tO\na\tO\nlarge\tO\nvolume\tO\nof\tO\nhypotonic\tO\nurine\tO\nwith\tO\nlow\tO\nionic\tO\nconcentrations\tO\n.\tO\n\nPlasma\tO\nsodium\tB-Chemical\nconcentrations\tO\nwere\tO\nfound\tO\nto\tO\nbe\tO\nslightly\tO\nincreased\tO\nin\tO\nthe\tO\nLi\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\ncompared\tO\nwith\tO\nthose\tO\nin\tO\ncontrols\tO\n.\tO\n\nPlasma\tO\nconcentration\tO\nof\tO\nAVP\tB-Chemical\nand\tO\ntranscripts\tO\nof\tO\nAVP\tB-Chemical\ngene\tO\nin\tO\nthe\tO\nPVN\tO\nand\tO\nSON\tO\nwere\tO\nsignificantly\tO\nincreased\tO\nin\tO\nthe\tO\nLi\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\ncompared\tO\nwith\tO\ncontrols\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\ndehydration\tB-Disease\nand\tO\n/\tO\nor\tO\nthe\tO\nactivation\tO\nof\tO\nvisceral\tO\nafferent\tO\ninputs\tO\nmay\tO\ncontribute\tO\nto\tO\nthe\tO\nelevation\tO\nof\tO\nplasma\tO\nAVP\tB-Chemical\nand\tO\nthe\tO\nupregulation\tO\nof\tO\nAVP\tB-Chemical\ngene\tO\nexpression\tO\nin\tO\nthe\tO\nPVN\tO\nand\tO\nthe\tO\nSON\tO\nof\tO\nthe\tO\nLi\tB-Chemical\n-\tO\ninduced\tO\ndiabetes\tB-Disease\ninsipidus\tI-Disease\nrat\tO\n.\tO\n\nAntinociceptive\tO\nand\tO\nantiamnesic\tO\nproperties\tO\nof\tO\nthe\tO\npresynaptic\tO\ncholinergic\tO\namplifier\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\n.\tO\n\nThe\tO\nantinociceptive\tO\neffect\tO\nof\tO\n3\tB-Chemical\nalpha\tI-Chemical\n-\tI-Chemical\ntropyl\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\np\tI-Chemical\n-\tI-Chemical\nbromophenyl\tI-Chemical\n)\tI-Chemical\npropionate\tI-Chemical\n[\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\n]\tO\n(\tO\n10\tO\n-\tO\n40\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ns\tO\n.\tO\nc\tO\n.\tO\n;\tO\n30\tO\n-\tO\n60\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\np\tO\n.\tO\no\tO\n.\tO\n;\tO\n10\tO\n-\tO\n30\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\nv\tO\n.\tO\n;\tO\n10\tO\n-\tO\n30\tO\nmicrograms\tO\n/\tO\nmouse\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\nwas\tO\nexamined\tO\nin\tO\nmice\tO\n,\tO\nrats\tO\nand\tO\nguinea\tO\npigs\tO\nby\tO\nuse\tO\nof\tO\nthe\tO\nhot\tO\n-\tO\nplate\tO\n,\tO\nabdominal\tO\n-\tO\nconstriction\tO\n,\tO\ntail\tO\n-\tO\nflick\tO\nand\tO\npaw\tO\n-\tO\npressure\tO\ntests\tO\n.\tO\n\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\nantinociception\tO\npeaked\tO\n15\tO\nmin\tO\nafter\tO\ninjection\tO\nand\tO\nthen\tO\nslowly\tO\ndiminished\tO\n.\tO\n\nThe\tO\nantinociception\tO\nproduced\tO\nby\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\nwas\tO\nprevented\tO\nby\tO\nthe\tO\nunselective\tO\nmuscarinic\tO\nantagonist\tO\natropine\tB-Chemical\n,\tO\nthe\tO\nM1\tO\n-\tO\nselective\tO\nantagonists\tO\npirenzepine\tB-Chemical\nand\tO\ndicyclomine\tB-Chemical\nand\tO\nthe\tO\nacetylcholine\tB-Chemical\ndepletor\tO\nhemicholinium\tB-Chemical\n-\tI-Chemical\n3\tI-Chemical\n,\tO\nbut\tO\nnot\tO\nby\tO\nthe\tO\nopioid\tO\nantagonist\tO\nnaloxone\tB-Chemical\n,\tO\nthe\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacidB\tI-Chemical\nantagonist\tO\n3\tB-Chemical\n-\tI-Chemical\naminopropyl\tI-Chemical\n-\tI-Chemical\ndiethoxy\tI-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nphosphinic\tI-Chemical\nacid\tI-Chemical\n,\tO\nthe\tO\nH3\tO\nagonist\tO\nR\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\nalpha\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nmethylhistamine\tI-Chemical\n,\tO\nthe\tO\nD2\tO\nantagonist\tO\nquinpirole\tB-Chemical\n,\tO\nthe\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptamine4\tI-Chemical\nantagonist\tO\n2\tB-Chemical\n-\tI-Chemical\nmethoxy\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\namino\tI-Chemical\n-\tI-Chemical\n5\tI-Chemical\n-\tI-Chemical\nchlorobenzoic\tI-Chemical\nacid\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\ndiethylamino\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\nester\tI-Chemical\nhydrochloride\tO\n,\tO\nthe\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptamin1A\tI-Chemical\nantagonist\tO\n1\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nmethoxyphenyl\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\nphthalimido\tI-Chemical\n)\tI-Chemical\nbutyl\tI-Chemical\n]\tI-Chemical\npiperazine\tI-Chemical\nhydrobromide\tO\nand\tO\nthe\tO\npolyamines\tO\ndepletor\tO\nreserpine\tB-Chemical\n.\tO\n\nBased\tO\non\tO\nthese\tO\ndata\tO\n,\tO\nit\tO\ncan\tO\nbe\tO\npostulated\tO\nthat\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\nexerted\tO\nan\tO\nantinociceptive\tO\neffect\tO\nmediated\tO\nby\tO\na\tO\ncentral\tO\npotentiation\tO\nof\tO\ncholinergic\tO\ntransmission\tO\n.\tO\n\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\n(\tO\n10\tO\n-\tO\n40\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nwas\tO\nable\tO\nto\tO\nprevent\tO\namnesia\tB-Disease\ninduced\tO\nby\tO\nscopolamine\tB-Chemical\n(\tO\n1\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nand\tO\ndicyclomine\tB-Chemical\n(\tO\n2\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nin\tO\nthe\tO\nmouse\tO\npassive\tO\n-\tO\navoidance\tO\ntest\tO\n.\tO\n\nAffinity\tO\nprofiles\tO\nof\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\nfor\tO\nmuscarinic\tO\nreceptor\tO\nsubtypes\tO\n,\tO\ndetermined\tO\nby\tO\nfunctional\tO\nstudies\tO\n(\tO\nrabbit\tO\nvas\tO\ndeferens\tO\nfor\tO\nM1\tO\n,\tO\nguinea\tO\npig\tO\natrium\tO\nfor\tO\nM2\tO\n,\tO\nguinea\tO\npig\tO\nileum\tO\nfor\tO\nM3\tO\nand\tO\nimmature\tO\nguinea\tO\npig\tO\nuterus\tO\nfor\tO\nputative\tO\nM4\tO\n)\tO\n,\tO\nhave\tO\nshown\tO\nan\tO\nM4\tO\n/\tO\nM1\tO\nselectivity\tO\nratio\tO\nof\tO\n10\tO\n.\tO\n2\tO\nthat\tO\nmight\tO\nbe\tO\nresponsible\tO\nfor\tO\nthe\tO\nantinociception\tO\nand\tO\nthe\tO\nanti\tO\n-\tO\namnesic\tB-Disease\neffect\tO\ninduced\tO\nby\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\nthrough\tO\nan\tO\nincrease\tO\nin\tO\nacetylcholine\tB-Chemical\nextracellular\tO\nlevels\tO\n.\tO\n\nIn\tO\nthe\tO\nantinociceptive\tO\nand\tO\nantiamnesic\tO\ndose\tO\nrange\tO\n,\tO\n(\tO\n+\tO\n/\tO\n-\tO\n)\tO\n-\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\ndid\tO\nnot\tO\nimpair\tO\nmouse\tO\nperformance\tO\nevaluated\tO\nby\tO\nthe\tO\nrota\tO\n-\tO\nrod\tO\ntest\tO\nand\tO\nAnimex\tO\napparatus\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\ndifferent\tO\nanaesthetic\tO\nagents\tO\nin\tO\nhearing\tB-Disease\nloss\tI-Disease\nfollowing\tO\nspinal\tO\nanaesthesia\tO\n.\tO\n\nThe\tO\ncause\tO\nof\tO\nhearing\tB-Disease\nloss\tI-Disease\nafter\tO\nspinal\tO\nanaesthesia\tO\nis\tO\nunknown\tO\n.\tO\n\nUp\tO\nuntil\tO\nnow\tO\n,\tO\nthe\tO\nonly\tO\nfactor\tO\nstudied\tO\nhas\tO\nbeen\tO\nthe\tO\neffect\tO\nof\tO\nthe\tO\ndiameter\tO\nof\tO\nthe\tO\nspinal\tO\nneedle\tO\non\tO\npost\tO\n-\tO\noperative\tO\nsensorineural\tB-Disease\nhearing\tI-Disease\nloss\tI-Disease\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndescribe\tO\nthis\tO\nhearing\tB-Disease\nloss\tI-Disease\nand\tO\nto\tO\ninvestigate\tO\nother\tO\nfactors\tO\ninfluencing\tO\nthe\tO\ndegree\tO\nof\tO\nhearing\tB-Disease\nloss\tI-Disease\n.\tO\n\nTwo\tO\ngroups\tO\nof\tO\n22\tO\nsimilar\tO\npatients\tO\nwere\tO\nstudied\tO\n:\tO\none\tO\ngroup\tO\nreceived\tO\n6\tO\nmL\tO\nprilocaine\tB-Chemical\n2\tO\n%\tO\n;\tO\nand\tO\nthe\tO\nother\tO\nreceived\tO\n3\tO\nmL\tO\nbupivacaine\tB-Chemical\n0\tO\n.\tO\n5\tO\n%\tO\n.\tO\n\nPatients\tO\ngiven\tO\nprilocaine\tB-Chemical\nwere\tO\nmore\tO\nlikely\tO\nto\tO\ndevelop\tO\nhearing\tB-Disease\nloss\tI-Disease\n(\tO\n10\tO\nout\tO\nof\tO\n22\tO\n)\tO\nthan\tO\nthose\tO\ngiven\tO\nbupivacaine\tB-Chemical\n(\tO\n4\tO\nout\tO\nof\tO\n22\tO\n)\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\naverage\tO\nhearing\tB-Disease\nloss\tI-Disease\nfor\tO\nspeech\tO\nfrequencies\tO\nwas\tO\nabout\tO\n10\tO\ndB\tO\nafter\tO\nprilocaine\tB-Chemical\nand\tO\n15\tO\ndB\tO\nafter\tO\nbupivacaine\tB-Chemical\n.\tO\n\nNone\tO\nof\tO\nthe\tO\npatients\tO\ncomplained\tO\nof\tO\nsubjective\tO\nhearing\tB-Disease\nloss\tI-Disease\n.\tO\n\nLong\tO\n-\tO\nterm\tO\nfollow\tO\n-\tO\nup\tO\nof\tO\nthe\tO\npatients\tO\nwas\tO\nnot\tO\npossible\tO\n.\tO\n\nA\tO\ntransient\tO\nneurological\tB-Disease\ndeficit\tI-Disease\nfollowing\tO\nintrathecal\tO\ninjection\tO\nof\tO\n1\tO\n%\tO\nhyperbaric\tO\nbupivacaine\tB-Chemical\nfor\tO\nunilateral\tO\nspinal\tO\nanaesthesia\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\ntransient\tO\nneurological\tB-Disease\ndeficit\tI-Disease\nthat\tO\noccurred\tO\nafter\tO\nunilateral\tO\nspinal\tO\nanaesthesia\tO\nwith\tO\n8\tO\nmg\tO\nof\tO\n1\tO\n%\tO\nhyperbaric\tO\nbupivacaine\tB-Chemical\nslowly\tO\ninjected\tO\nthrough\tO\na\tO\n25\tO\n-\tO\ngauge\tO\npencil\tO\n-\tO\npoint\tO\nspinal\tO\nneedle\tO\n.\tO\n\nThe\tO\nsurgery\tO\nand\tO\nanaesthesia\tO\nwere\tO\nuneventful\tO\n,\tO\nbut\tO\n3\tO\ndays\tO\nafter\tO\nsurgery\tO\n,\tO\nthe\tO\npatient\tO\nreported\tO\nan\tO\narea\tO\nof\tO\nhypoaesthesia\tO\nover\tO\nL3\tO\n-\tO\nL4\tO\ndermatomes\tO\nof\tO\nthe\tO\nleg\tO\nwhich\tO\nhad\tO\nbeen\tO\noperated\tO\non\tO\n(\tO\nloss\tB-Disease\nof\tI-Disease\npinprick\tI-Disease\nsensation\tI-Disease\n)\tO\nwithout\tO\nreduction\tO\nin\tO\nmuscular\tO\nstrength\tO\n.\tO\n\nSensation\tO\nin\tO\nthis\tO\narea\tO\nreturned\tO\nto\tO\nnormal\tO\nover\tO\nthe\tO\nfollowing\tO\n2\tO\nweeks\tO\n.\tO\n\nProspective\tO\nmulticentre\tO\nstudies\tO\nwith\tO\na\tO\nlarge\tO\npopulation\tO\nand\tO\na\tO\nlong\tO\nfollow\tO\n-\tO\nup\tO\nshould\tO\nbe\tO\nperformed\tO\nin\tO\norder\tO\nto\tO\nevaluate\tO\nthe\tO\nincidence\tO\nof\tO\nthis\tO\nunusual\tO\nside\tO\neffect\tO\n.\tO\n\nHowever\tO\n,\tO\nwe\tO\nsuggest\tO\nthat\tO\na\tO\nlow\tO\nsolution\tO\nconcentration\tO\nshould\tO\nbe\tO\npreferred\tO\nfor\tO\nunilateral\tO\nspinal\tO\nanaesthesia\tO\nwith\tO\na\tO\nhyperbaric\tO\nanaesthetic\tO\nsolution\tO\n(\tO\nif\tO\npencil\tO\n-\tO\npoint\tO\nneedle\tO\nand\tO\nslow\tO\ninjection\tO\nrate\tO\nare\tO\nemployed\tO\n)\tO\n,\tO\nin\tO\norder\tO\nto\tO\nminimize\tO\nthe\tO\nrisk\tO\nof\tO\na\tO\nlocalized\tO\nhigh\tO\npeak\tO\nanaesthetic\tO\nconcentration\tO\n,\tO\nwhich\tO\nmight\tO\nlead\tO\nto\tO\na\tO\ntransient\tO\nneurological\tB-Disease\ndeficit\tI-Disease\n.\tO\n\nTransient\tB-Disease\nneurologic\tI-Disease\nsymptoms\tI-Disease\nafter\tO\nspinal\tO\nanesthesia\tO\n:\tO\na\tO\nlower\tO\nincidence\tO\nwith\tO\nprilocaine\tB-Chemical\nand\tO\nbupivacaine\tB-Chemical\nthan\tO\nwith\tO\nlidocaine\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nRecent\tO\nevidence\tO\nsuggests\tO\nthat\tO\ntransient\tB-Disease\nneurologic\tI-Disease\nsymptoms\tI-Disease\n(\tO\nTNSs\tB-Disease\n)\tO\nfrequently\tO\nfollow\tO\nlidocaine\tB-Chemical\nspinal\tO\nanesthesia\tO\nbut\tO\nare\tO\ninfrequent\tO\nwith\tO\nbupivacaine\tB-Chemical\n.\tO\n\nHowever\tO\n,\tO\nidentification\tO\nof\tO\na\tO\nshort\tO\n-\tO\nacting\tO\nlocal\tO\nanesthetic\tO\nto\tO\nsubstitute\tO\nfor\tO\nlidocaine\tB-Chemical\nfor\tO\nbrief\tO\nsurgical\tO\nprocedures\tO\nremains\tO\nan\tO\nimportant\tO\ngoal\tO\n.\tO\n\nPrilocaine\tB-Chemical\nis\tO\nan\tO\namide\tO\nlocal\tO\nanesthetic\tO\nwith\tO\na\tO\nduration\tO\nof\tO\naction\tO\nsimilar\tO\nto\tO\nthat\tO\nof\tO\nlidocaine\tB-Chemical\n.\tO\n\nAccordingly\tO\n,\tO\nthe\tO\npresent\tO\n,\tO\nprospective\tO\ndouble\tO\n-\tO\nblind\tO\nstudy\tO\ncompares\tO\nprilocaine\tB-Chemical\nwith\tO\nlidocaine\tB-Chemical\nand\tO\nbupivacaine\tB-Chemical\nwith\tO\nrespect\tO\nto\tO\nduration\tO\nof\tO\naction\tO\nand\tO\nrelative\tO\nrisk\tO\nof\tO\nTNSs\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nNinety\tO\npatients\tO\nclassified\tO\nas\tO\nAmerican\tO\nSociety\tO\nof\tO\nAnesthesiologists\tO\nphysical\tO\nstatus\tO\nI\tO\nor\tO\nII\tO\nwho\tO\nwere\tO\nscheduled\tO\nfor\tO\nshort\tO\ngynecologic\tO\nprocedures\tO\nunder\tO\nspinal\tO\nanesthesia\tO\nwere\tO\nrandomly\tO\nallocated\tO\nto\tO\nreceive\tO\n2\tO\n.\tO\n5\tO\nml\tO\n2\tO\n%\tO\nlidocaine\tB-Chemical\nin\tO\n7\tO\n.\tO\n5\tO\n%\tO\nglucose\tB-Chemical\n,\tO\n2\tO\n%\tO\nprilocaine\tB-Chemical\nin\tO\n7\tO\n.\tO\n5\tO\n%\tO\nglucose\tB-Chemical\n,\tO\nor\tO\n0\tO\n.\tO\n5\tO\n%\tO\nbupivacaine\tB-Chemical\nin\tO\n7\tO\n.\tO\n5\tO\n%\tO\nglucose\tB-Chemical\n.\tO\n\nAll\tO\nsolutions\tO\nwere\tO\nprovided\tO\nin\tO\nblinded\tO\nvials\tO\nby\tO\nthe\tO\nhospital\tO\npharmacy\tO\n.\tO\n\nDetails\tO\nof\tO\nspinal\tO\npuncture\tO\n,\tO\nextension\tO\nand\tO\nregression\tO\nof\tO\nspinal\tO\nblock\tO\n,\tO\nand\tO\nthe\tO\ntimes\tO\nto\tO\nreach\tO\ndischarge\tO\ncriteria\tO\nwere\tO\nnoted\tO\n.\tO\n\nIn\tO\nthe\tO\nevening\tO\nof\tO\npostoperative\tO\nday\tO\n1\tO\n,\tO\npatients\tO\nwere\tO\nevaluated\tO\nfor\tO\nTNSs\tB-Disease\nby\tO\na\tO\nphysician\tO\nunaware\tO\nof\tO\nthe\tO\ndrug\tO\nadministered\tO\nand\tO\nthe\tO\ndetails\tO\nof\tO\nthe\tO\nanesthetic\tO\nprocedure\tO\n.\tO\n\nRESULTS\tO\n:\tO\nNine\tO\nof\tO\n30\tO\npatients\tO\nreceiving\tO\nlidocaine\tB-Chemical\nexperienced\tO\nTNSs\tB-Disease\n,\tO\n1\tO\nof\tO\n30\tO\npatients\tO\nreceiving\tO\nprilocaine\tB-Chemical\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n03\tO\n)\tO\nhad\tO\nthem\tO\n,\tO\nand\tO\nnone\tO\nof\tO\n30\tO\npatients\tO\nreceiving\tO\nbupivacaine\tB-Chemical\nhad\tO\nTNSs\tB-Disease\n.\tO\n\nTimes\tO\nto\tO\nambulate\tO\nand\tO\nto\tO\nvoid\tO\nwere\tO\nsimilar\tO\nafter\tO\nlidocaine\tB-Chemical\nand\tO\nprilocaine\tB-Chemical\n(\tO\n150\tO\nvs\tO\n.\tO\n165\tO\nmin\tO\nand\tO\n238\tO\nvs\tO\n.\tO\n253\tO\nmin\tO\n,\tO\nrespectively\tO\n)\tO\nbut\tO\nprolonged\tO\nafter\tO\nbupivacaine\tB-Chemical\n(\tO\n200\tO\nand\tO\n299\tO\nmin\tO\n,\tO\nrespectively\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPrilocaine\tB-Chemical\nmay\tO\nbe\tO\npreferable\tO\nto\tO\nlidocaine\tB-Chemical\nfor\tO\nshort\tO\nsurgical\tO\nprocedures\tO\nbecause\tO\nit\tO\nhas\tO\na\tO\nsimilar\tO\nduration\tO\nof\tO\naction\tO\nbut\tO\na\tO\nlower\tO\nincidence\tO\nof\tO\nTNSs\tB-Disease\n.\tO\n\nSuxamethonium\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\narrest\tI-Disease\nand\tO\ndeath\tB-Disease\nfollowing\tO\n5\tO\ndays\tO\nof\tO\nimmobilization\tO\n.\tO\n\nThe\tO\npresent\tO\nreport\tO\ndescribes\tO\na\tO\ncase\tO\nof\tO\ncardiac\tB-Disease\narrest\tI-Disease\nand\tO\nsubsequent\tO\ndeath\tB-Disease\nas\tO\na\tO\nresult\tO\nof\tO\nhyperkalaemia\tB-Disease\nfollowing\tO\nthe\tO\nuse\tO\nof\tO\nsuxamethonium\tB-Chemical\nin\tO\na\tO\n23\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nMalawian\tO\nwoman\tO\n.\tO\n\nFive\tO\ndays\tO\nafter\tO\nthe\tO\nonset\tO\nof\tO\nthe\tO\nsymptoms\tO\nof\tO\nmeningitis\tB-Disease\n,\tO\nthe\tO\npatient\tO\naspirated\tO\nstomach\tO\ncontents\tO\nand\tO\nneeded\tO\nendotracheal\tO\nintubation\tO\n.\tO\n\nForty\tO\nseconds\tO\nafter\tO\ninjection\tO\nof\tO\nsuxamethonium\tB-Chemical\n,\tO\nbradycardia\tB-Disease\nand\tO\ncardiac\tB-Disease\narrest\tI-Disease\noccurred\tO\n.\tO\n\nAttempts\tO\nto\tO\nresuscitate\tO\nthe\tO\npatient\tO\nwere\tO\nnot\tO\nsuccessful\tO\n.\tO\n\nThe\tO\nserum\tO\nlevel\tO\nof\tO\npotassium\tB-Chemical\nwas\tO\nobserved\tO\nto\tO\nbe\tO\n8\tO\n.\tO\n4\tO\nmequiv\tO\nL\tO\n-\tO\n1\tO\n.\tO\n\nApart\tO\nfrom\tO\nthe\tO\nreduction\tO\nin\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\nlevel\tO\nof\tO\nconsciousness\tO\n,\tO\nthere\tO\nwere\tO\nno\tO\nsigns\tO\nof\tO\nmotor\tO\nneurone\tO\ndamage\tO\nor\tO\nof\tO\nany\tO\nof\tO\nthe\tO\nother\tO\nknown\tO\npredisposing\tO\nconditions\tO\nfor\tO\nhyperkalaemia\tB-Disease\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\nsuxamethonium\tB-Chemical\n.\tO\n\nIt\tO\nis\tO\npostulated\tO\nthat\tO\nher\tO\ndeath\tB-Disease\nwas\tO\ncaused\tO\nby\tO\nhypersensitivity\tB-Disease\nto\tO\nsuxamethonium\tB-Chemical\n,\tO\nassociated\tO\nwith\tO\nher\tO\n5\tO\n-\tO\nday\tO\nimmobilization\tO\n.\tO\n\nAcute\tO\nhepatitis\tB-Disease\n,\tO\nautoimmune\tB-Disease\nhemolytic\tI-Disease\nanemia\tI-Disease\n,\tO\nand\tO\nerythroblastocytopenia\tB-Disease\ninduced\tO\nby\tO\nceftriaxone\tB-Chemical\n.\tO\n\nAn\tO\n80\tO\n-\tO\nyr\tO\n-\tO\nold\tO\nman\tO\ndeveloped\tO\nacute\tO\nhepatitis\tB-Disease\nshortly\tO\nafter\tO\ningesting\tO\noral\tO\nceftriaxone\tB-Chemical\n.\tO\n\nAlthough\tO\nthe\tO\ntransaminases\tO\ngradually\tO\nreturned\tO\nto\tO\nbaseline\tO\nafter\tO\nwithholding\tO\nthe\tO\nbeta\tB-Chemical\nlactam\tI-Chemical\nantibiotic\tO\n,\tO\nthere\tO\nwas\tO\na\tO\ngradual\tO\nincrease\tO\nin\tO\nserum\tO\nbilirubin\tB-Chemical\nand\tO\na\tO\ndecrease\tO\nin\tO\nhemoglobin\tO\nconcentration\tO\ncaused\tO\nby\tO\nan\tO\nautoimmune\tB-Disease\nhemolytic\tI-Disease\nanemia\tI-Disease\nand\tO\nerythroblastocytopenia\tB-Disease\n.\tO\n\nThese\tO\nresponded\tO\nto\tO\nsystemic\tO\nsteroids\tB-Chemical\nand\tO\nimmunoglobulins\tO\n.\tO\n\nDespite\tO\nthe\tO\nwidespread\tO\nuse\tO\nof\tO\nthese\tO\nagents\tO\nthis\tO\ntriad\tO\nof\tO\nside\tO\neffects\tO\nhas\tO\nnot\tO\npreviously\tO\nbeen\tO\nreported\tO\nin\tO\nconnection\tO\nwith\tO\nbeta\tB-Chemical\nlactam\tI-Chemical\nantibiotics\tO\n.\tO\n\nThyroxine\tB-Chemical\nabuse\tO\n:\tO\nan\tO\nunusual\tO\ncase\tO\nof\tO\nthyrotoxicosis\tB-Disease\nin\tO\npregnancy\tO\n.\tO\n\nEating\tB-Disease\ndisorders\tI-Disease\nand\tO\nthe\tO\nassociated\tO\nbehavioural\tO\nproblems\tO\nand\tO\ndrug\tB-Disease\nabuse\tI-Disease\nare\tO\nuncommon\tO\nin\tO\npregnancy\tO\n.\tO\n\nWhen\tO\nthey\tO\ndo\tO\noccur\tO\nthey\tO\nare\tO\noften\tO\nunrecognized\tO\nbecause\tO\nof\tO\ndenial\tO\nbut\tO\nwhen\tO\nsignificant\tO\nmay\tO\npose\tO\na\tO\nrisk\tO\nto\tO\nboth\tO\nthe\tO\nmother\tO\nand\tO\nher\tO\nfetus\tO\n.\tO\n\nThis\tO\ncase\tO\nillustrates\tO\na\tO\nnumber\tO\nof\tO\nproblems\tO\nthat\tO\nmay\tO\nbe\tO\nencountered\tO\nin\tO\nwomen\tO\nwith\tO\neating\tB-Disease\ndisorders\tI-Disease\nin\tO\npregnancy\tO\n,\tO\nincluding\tO\nprolonged\tO\nand\tO\nrecurrent\tO\nmetabolic\tO\ndisturbances\tO\nand\tO\ndiuretic\tO\nabuse\tO\n.\tO\n\nIn\tO\nparticular\tO\nit\tO\nillustrates\tO\nthe\tO\nderangements\tO\nof\tO\nthyroid\tO\nfunction\tO\nseen\tO\nin\tO\npregnant\tO\nwomen\tO\nwith\tO\neating\tB-Disease\ndisorders\tI-Disease\nand\tO\nreminds\tO\nus\tO\nthat\tO\nwhen\tO\na\tO\ncause\tO\nfor\tO\nthyrotoxicosis\tB-Disease\nremains\tO\nobscure\tO\n,\tO\nthyroxine\tB-Chemical\nabuse\tO\nshould\tO\nbe\tO\nconsidered\tO\nand\tO\nexplored\tO\n.\tO\n\nRepeated\tO\ntrimipramine\tB-Chemical\ninduces\tO\ndopamine\tB-Chemical\nD2\tO\n/\tO\nD3\tO\nand\tO\nalpha1\tO\n-\tO\nadrenergic\tO\nup\tO\n-\tO\nregulation\tO\n.\tO\n\nTrimipramine\tB-Chemical\n(\tO\nTRI\tB-Chemical\n)\tO\n,\tO\nwhich\tO\nshows\tO\na\tO\nclinical\tO\nantidepressant\tB-Chemical\nactivity\tO\n,\tO\nis\tO\nchemically\tO\nrelated\tO\nto\tO\nimipramine\tB-Chemical\nbut\tO\ndoes\tO\nnot\tO\ninhibit\tO\nthe\tO\nreuptake\tO\nof\tO\nnoradrenaline\tB-Chemical\nand\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptamine\tI-Chemical\n,\tO\nnor\tO\ndoes\tO\nit\tO\ninduce\tO\nbeta\tO\n-\tO\nadrenergic\tO\ndown\tO\n-\tO\nregulation\tO\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\nits\tO\nantidepressant\tB-Chemical\nactivity\tO\nis\tO\nstill\tO\nunknown\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\nfind\tO\nout\tO\nwhether\tO\nTRI\tB-Chemical\ngiven\tO\nrepeatedly\tO\nwas\tO\nable\tO\nto\tO\ninduce\tO\nadaptive\tO\nchanges\tO\nin\tO\nthe\tO\ndopaminergic\tO\nand\tO\nalpha1\tO\n-\tO\nadrenergic\tO\nsystems\tO\n,\tO\ndemonstrated\tO\nby\tO\nus\tO\npreviously\tO\nfor\tO\nvarious\tO\nantidepressants\tB-Chemical\n.\tO\n\nTRI\tB-Chemical\nwas\tO\ngiven\tO\nto\tO\nmale\tO\nWistar\tO\nrats\tO\nand\tO\nmale\tO\nAlbino\tO\nSwiss\tO\nmice\tO\nperorally\tO\ntwice\tO\ndaily\tO\nfor\tO\n14\tO\ndays\tO\n.\tO\n\nIn\tO\nthe\tO\nacute\tO\nexperiment\tO\nTRI\tB-Chemical\n(\tO\ngiven\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\ndoes\tO\nnot\tO\nantagonize\tO\nthe\tO\nreserpine\tB-Chemical\nhypothermia\tB-Disease\nin\tO\nmice\tO\nand\tO\ndoes\tO\nnot\tO\npotentiate\tO\nthe\tO\n5\tB-Chemical\n-\tI-Chemical\nhydroxytryptophan\tI-Chemical\nhead\tO\ntwitches\tO\nin\tO\nrats\tO\n.\tO\n\nTRI\tB-Chemical\ngiven\tO\nrepeatedly\tO\nto\tO\nrats\tO\nincreases\tO\nthe\tO\nlocomotor\tO\nhyperactivity\tB-Disease\ninduced\tO\nby\tO\nd\tB-Chemical\n-\tI-Chemical\namphetamine\tI-Chemical\n,\tO\nquinpirole\tB-Chemical\nand\tO\n(\tO\n+\tO\n)\tO\n-\tO\n7\tO\n-\tO\nhydroxy\tO\n-\tO\ndipropyloaminotetralin\tO\n(\tO\ndopamine\tB-Chemical\nD2\tO\nand\tO\nD3\tO\neffects\tO\n)\tO\n.\tO\n\nThe\tO\nstereotypies\tO\ninduced\tO\nby\tO\nd\tB-Chemical\n-\tI-Chemical\namphetamine\tI-Chemical\nor\tO\napomorphine\tB-Chemical\nare\tO\nnot\tO\npotentiated\tO\nby\tO\nTRI\tB-Chemical\n.\tO\n\nIt\tO\nincreases\tO\nthe\tO\nbehaviour\tO\nstimulation\tO\nevoked\tO\nby\tO\nphenylephrine\tB-Chemical\n(\tO\ngiven\tO\nintraventricularly\tO\n)\tO\nin\tO\nrats\tO\n,\tO\nevaluated\tO\nin\tO\nthe\tO\nopen\tO\nfield\tO\ntest\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\naggressiveness\tB-Disease\nevoked\tO\nby\tO\nclonidine\tB-Chemical\nin\tO\nmice\tO\n,\tO\nboth\tO\nthese\tO\neffects\tO\nbeing\tO\nmediated\tO\nby\tO\nan\tO\nalpha1\tO\n-\tO\nadrenergic\tO\nreceptor\tO\n.\tO\n\nIt\tO\nmay\tO\nbe\tO\nconcluded\tO\nthat\tO\n,\tO\nlike\tO\nother\tO\ntricyclic\tO\nantidepressants\tB-Chemical\nstudied\tO\npreviously\tO\n,\tO\nTRI\tB-Chemical\ngiven\tO\nrepeatedly\tO\nincreases\tO\nthe\tO\nresponsiveness\tO\nof\tO\nbrain\tO\ndopamine\tB-Chemical\nD2\tO\nand\tO\nD3\tO\n(\tO\nlocomotor\tO\nactivity\tO\nbut\tO\nnot\tO\nstereotypy\tO\n)\tO\nas\tO\nwell\tO\nas\tO\nalpha1\tO\n-\tO\nadrenergic\tO\nreceptors\tO\nto\tO\ntheir\tO\nagonists\tO\n.\tO\n\nA\tO\nquestion\tO\narises\tO\nwhether\tO\nthe\tO\nreuptake\tO\ninhibition\tO\nis\tO\nof\tO\nany\tO\nimportance\tO\nto\tO\nthe\tO\nadaptive\tO\nchanges\tO\ninduced\tO\nby\tO\nrepeated\tO\nantidepressants\tB-Chemical\n,\tO\nsuggested\tO\nto\tO\nbe\tO\nresponsible\tO\nfor\tO\nthe\tO\nantidepressant\tB-Chemical\nactivity\tO\n.\tO\n\nPethidine\tB-Chemical\n-\tO\nassociated\tO\nseizure\tB-Disease\nin\tO\na\tO\nhealthy\tO\nadolescent\tO\nreceiving\tO\npethidine\tB-Chemical\nfor\tO\npostoperative\tB-Disease\npain\tI-Disease\ncontrol\tO\n.\tO\n\nA\tO\nhealthy\tO\n17\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nmale\tO\nreceived\tO\nstandard\tO\nintermittent\tO\ndoses\tO\nof\tO\npethidine\tB-Chemical\nvia\tO\na\tO\npatient\tO\n-\tO\ncontrolled\tO\nanalgesia\tO\n(\tO\nPCA\tO\n)\tO\npump\tO\nfor\tO\nmanagement\tO\nof\tO\npostoperative\tB-Disease\npain\tI-Disease\ncontrol\tO\n.\tO\n\nTwenty\tO\n-\tO\nthree\tO\nh\tO\npostoperatively\tO\nhe\tO\ndeveloped\tO\na\tO\nbrief\tO\nself\tO\n-\tO\nlimited\tO\nseizure\tB-Disease\n.\tO\n\nBoth\tO\nplasma\tO\npethidine\tB-Chemical\nand\tO\nnorpethidine\tB-Chemical\nwere\tO\nelevated\tO\nin\tO\nthe\tO\nrange\tO\nassociated\tO\nwith\tO\nclinical\tO\nmanifestations\tO\nof\tO\ncentral\tO\nnervous\tO\nsystem\tO\nexcitation\tO\n.\tO\n\nNo\tO\nother\tO\nrisk\tO\nfactors\tO\nfor\tO\nCNS\tO\ntoxicity\tB-Disease\nwere\tO\nidentified\tO\n.\tO\n\nThis\tO\nmethod\tO\nallowed\tO\nfrequent\tO\nself\tO\n-\tO\ndosing\tO\nof\tO\npethidine\tB-Chemical\nat\tO\nshort\tO\ntime\tO\nintervals\tO\nand\tO\nrapid\tO\naccumulation\tO\nof\tO\npethidine\tB-Chemical\nand\tO\nnorpethidine\tB-Chemical\n.\tO\n\nThe\tO\nroutine\tO\nuse\tO\nof\tO\npethidine\tB-Chemical\nvia\tO\nPCA\tO\neven\tO\nfor\tO\na\tO\nbrief\tO\npostoperative\tO\nanalgesia\tO\nshould\tO\nbe\tO\nreconsidered\tO\n.\tO\n\nAn\tO\nunusual\tO\ntoxic\tO\nreaction\tO\nto\tO\naxillary\tO\nblock\tO\nby\tO\nmepivacaine\tB-Chemical\nwith\tO\nadrenaline\tB-Chemical\n.\tO\n\nAn\tO\nincrease\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\n,\tO\naccompanied\tO\nby\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n,\tO\nagitation\tB-Disease\n,\tO\nincomprehensible\tB-Disease\nshouts\tI-Disease\nand\tO\nloss\tB-Disease\nof\tI-Disease\nconsciousness\tI-Disease\n,\tO\nwas\tO\nobserved\tO\nin\tO\nan\tO\nelderly\tO\n,\tO\nASA\tO\nclassification\tO\ngroup\tO\nII\tO\n,\tO\ncardiovascularly\tO\nmedicated\tO\nmale\tO\n,\tO\n12\tO\nmin\tO\nafter\tO\nperformance\tO\nof\tO\naxillary\tO\nblock\tO\nwith\tO\nmepivacaine\tB-Chemical\n850\tO\nmg\tO\ncontaining\tO\nadrenaline\tB-Chemical\n0\tO\n.\tO\n225\tO\nmg\tO\n,\tO\nfor\tO\ncorrection\tO\nof\tO\nDupuytren\tB-Disease\n'\tI-Disease\ns\tI-Disease\ncontracture\tI-Disease\n.\tO\n\nAfter\tO\nintravenous\tO\nadministration\tO\nof\tO\nlabetalol\tB-Chemical\n,\tO\nmetoprolol\tB-Chemical\nand\tO\nmidazolam\tB-Chemical\nthe\tO\npatient\tO\n'\tO\ns\tO\ncondition\tO\nimproved\tO\n,\tO\nand\tO\n15\tO\nmin\tO\nlater\tO\nhe\tO\nwoke\tO\nup\tO\n.\tO\n\nThe\tO\nblock\tO\nwas\tO\nsuccessful\tO\nand\tO\nsurgery\tO\nwas\tO\nconducted\tO\nas\tO\nscheduled\tO\ndespite\tO\npersisting\tO\natrial\tB-Disease\nfibrillation\tI-Disease\n.\tO\n\nPostoperatively\tO\n,\tO\nthe\tO\npatient\tO\nrefused\tO\nDC\tO\ncardioversion\tO\nand\tO\nwas\tO\ntreated\tO\nmedically\tO\n.\tO\n\nBoth\tO\nthe\tO\ntemporal\tO\nrelationship\tO\nof\tO\nevents\tO\nand\tO\nthe\tO\nresponse\tO\nto\tO\ntreatment\tO\nsuggest\tO\nthat\tO\na\tO\nrapid\tO\nsystemic\tO\nabsorption\tO\nof\tO\nmepivacaine\tB-Chemical\nwith\tO\nadrenaline\tB-Chemical\nand\tO\n/\tO\nor\tO\ninteraction\tO\nof\tO\nthese\tO\ndrugs\tO\nwith\tO\nthe\tO\npatient\tO\n'\tO\ns\tO\ncardiovascular\tO\nmedications\tO\nwere\tO\nresponsible\tO\nfor\tO\nthe\tO\nperioperative\tO\ncomplications\tO\n.\tO\n\nDrug\tO\n-\tO\nassociated\tO\nacute\tO\n-\tO\nonset\tO\nvanishing\tB-Disease\nbile\tI-Disease\nduct\tI-Disease\nand\tO\nStevens\tB-Disease\n-\tI-Disease\nJohnson\tI-Disease\nsyndromes\tI-Disease\nin\tO\na\tO\nchild\tO\n.\tO\n\nAcute\tO\nvanishing\tB-Disease\nbile\tI-Disease\nduct\tI-Disease\nsyndrome\tO\nis\tO\na\tO\nrare\tO\nbut\tO\nestablished\tO\ncause\tO\nof\tO\nprogressive\tO\ncholestasis\tB-Disease\nin\tO\nadults\tO\n,\tO\nis\tO\nmost\tO\noften\tO\ndrug\tO\nor\tO\ntoxin\tO\nrelated\tO\n,\tO\nand\tO\nis\tO\nof\tO\nunknown\tO\npathogenesis\tO\n.\tO\n\nIt\tO\nhas\tO\nnot\tO\nbeen\tO\nreported\tO\npreviously\tO\nin\tO\nchildren\tO\n.\tO\n\nStevens\tB-Disease\n-\tI-Disease\nJohnson\tI-Disease\nsyndrome\tI-Disease\nis\tO\na\tO\nwell\tO\n-\tO\nrecognized\tO\nimmune\tO\ncomplex\tO\n-\tO\nmediated\tO\nhypersensitivity\tB-Disease\nreaction\tO\nthat\tO\naffects\tO\nall\tO\nage\tO\ngroups\tO\n,\tO\nis\tO\ndrug\tO\nor\tO\ninfection\tB-Disease\ninduced\tO\n,\tO\nand\tO\nhas\tO\nclassic\tO\nsystemic\tO\n,\tO\nmucosal\tO\n,\tO\nand\tO\ndermatologic\tO\nmanifestations\tO\n.\tO\n\nA\tO\npreviously\tO\nhealthy\tO\nchild\tO\nwho\tO\ndeveloped\tO\nacute\tO\n,\tO\nsevere\tO\n,\tO\nrapidly\tO\nprogressive\tO\nvanishing\tB-Disease\nbile\tI-Disease\nduct\tI-Disease\nsyndrome\tI-Disease\nshortly\tO\nafter\tO\nStevens\tB-Disease\n-\tI-Disease\nJohnson\tI-Disease\nsyndrome\tI-Disease\nis\tO\ndescribed\tO\n;\tO\nthis\tO\nwas\tO\ntemporally\tO\nassociated\tO\nwith\tO\nibuprofen\tB-Chemical\nuse\tO\n.\tO\n\nDespite\tO\ntherapy\tO\nwith\tO\nursodeoxycholic\tB-Chemical\nacid\tI-Chemical\n,\tO\nprednisone\tB-Chemical\n,\tO\nand\tO\nthen\tO\ntacrolimus\tB-Chemical\n,\tO\nher\tO\ncholestatic\tB-Disease\ndisease\tI-Disease\nwas\tO\nunrelenting\tO\n,\tO\nwith\tO\ncirrhosis\tB-Disease\nshown\tO\nby\tO\nbiopsy\tO\n6\tO\nmonths\tO\nafter\tO\npresentation\tO\n.\tO\n\nThis\tO\ncase\tO\ndocuments\tO\nacute\tO\ndrug\tO\n-\tO\nrelated\tO\nvanishing\tB-Disease\nbile\tI-Disease\nduct\tI-Disease\nsyndrome\tI-Disease\nin\tO\nthe\tO\npediatric\tO\nage\tO\ngroup\tO\nand\tO\nsuggests\tO\nshared\tO\nimmune\tO\nmechanisms\tO\nin\tO\nthe\tO\npathogenesis\tO\nof\tO\nboth\tO\nStevens\tB-Disease\n-\tI-Disease\nJohnson\tI-Disease\nsyndrome\tI-Disease\nand\tO\nvanishing\tB-Disease\nbile\tI-Disease\nduct\tI-Disease\nsyndrome\tI-Disease\n.\tO\n\nHigh\tO\nincidence\tO\nof\tO\nprimary\tB-Disease\npulmonary\tI-Disease\nhypertension\tI-Disease\nassociated\tO\nwith\tO\nappetite\tB-Chemical\nsuppressants\tI-Chemical\nin\tO\nBelgium\tO\n.\tO\n\nPrimary\tB-Disease\npulmonary\tI-Disease\nhypertension\tI-Disease\nis\tO\na\tO\nrare\tO\n,\tO\nprogressive\tO\nand\tO\nincurable\tO\ndisease\tO\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nthe\tO\nintake\tO\nof\tO\nappetite\tB-Chemical\nsuppressant\tI-Chemical\ndrugs\tO\n.\tO\n\nThe\tO\nimportance\tO\nof\tO\nthis\tO\nassociation\tO\nwas\tO\nevaluated\tO\nin\tO\nBelgium\tO\nwhile\tO\nthis\tO\ncountry\tO\nstill\tO\nhad\tO\nno\tO\nrestriction\tO\non\tO\nthe\tO\nprescription\tO\nof\tO\nappetite\tB-Chemical\nsuppressants\tI-Chemical\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\npatients\tO\nwith\tO\nprimary\tB-Disease\npulmonary\tI-Disease\nhypertension\tI-Disease\nand\tO\n85\tO\nmatched\tO\ncontrols\tO\nwere\tO\nrecruited\tO\nover\tO\n32\tO\nmonths\tO\n(\tO\n1992\tO\n-\tO\n1994\tO\n)\tO\nin\tO\nBelgium\tO\n.\tO\n\nExposure\tO\nto\tO\nappetite\tB-Chemical\n-\tI-Chemical\nsuppressants\tI-Chemical\nwas\tO\nassessed\tO\non\tO\nthe\tO\nbasis\tO\nof\tO\nhospital\tO\nrecords\tO\nand\tO\nstandardized\tO\ninterview\tO\n.\tO\n\nTwenty\tO\n-\tO\nthree\tO\nof\tO\nthe\tO\npatients\tO\nhad\tO\npreviously\tO\ntaken\tO\nappetite\tB-Chemical\nsuppressants\tI-Chemical\n,\tO\nmainly\tO\nfenfluramines\tB-Chemical\n,\tO\nas\tO\ncompared\tO\nwith\tO\nonly\tO\n5\tO\nof\tO\nthe\tO\ncontrols\tO\n(\tO\n66\tO\nversus\tO\n6\tO\n%\tO\n,\tO\np\tO\n<\tO\n0\tO\n.\tO\n0001\tO\n)\tO\n.\tO\n\nFive\tO\npatients\tO\ndied\tO\nbefore\tO\nthe\tO\ninterview\tO\n,\tO\nall\tO\nof\tO\nthem\tO\nhad\tO\ntaken\tO\nappetite\tB-Chemical\nsuppressants\tI-Chemical\n.\tO\n\nIn\tO\n8\tO\npatients\tO\nthe\tO\ndiagnosis\tO\nof\tO\nprimary\tB-Disease\npulmonary\tI-Disease\nhypertension\tI-Disease\nwas\tO\nuncertain\tO\n,\tO\n5\tO\nof\tO\nthem\tO\nhad\tO\ntaken\tO\nappetite\tB-Chemical\nsuppressants\tI-Chemical\n.\tO\n\nThe\tO\npatients\tO\nwho\tO\nhad\tO\nbeen\tO\nexposed\tO\nto\tO\nappetite\tB-Chemical\nsuppressants\tI-Chemical\ntended\tO\nto\tO\nbe\tO\non\tO\naverage\tO\nmore\tO\nseverely\tO\nill\tO\n,\tO\nand\tO\nto\tO\nhave\tO\na\tO\nshorter\tO\nmedian\tO\ndelay\tO\nbetween\tO\nonset\tO\nof\tO\nsymptoms\tO\nand\tO\ndiagnosis\tO\n.\tO\n\nA\tO\npolicy\tO\nof\tO\nunrestricted\tO\nprescription\tO\nof\tO\nappetite\tB-Chemical\nsuppressants\tI-Chemical\nmay\tO\nlead\tO\nto\tO\na\tO\nhigh\tO\nincidence\tO\nof\tO\nassociated\tO\nprimary\tB-Disease\npulmonary\tI-Disease\nhypertension\tI-Disease\n.\tO\n\nIntake\tO\nof\tO\nappetite\tB-Chemical\nsuppressants\tI-Chemical\nmay\tO\naccelerate\tO\nthe\tO\nprogression\tO\nof\tO\nthe\tO\ndisease\tO\n.\tO\n\nInappropriate\tO\nuse\tO\nof\tO\ncarbamazepine\tB-Chemical\nand\tO\nvigabatrin\tB-Chemical\nin\tO\ntypical\tO\nabsence\tB-Disease\nseizures\tI-Disease\n.\tO\n\nCarbamazepine\tB-Chemical\nand\tO\nvigabatrin\tB-Chemical\nare\tO\ncontraindicated\tO\nin\tO\ntypical\tO\nabsence\tB-Disease\nseizures\tI-Disease\n.\tO\n\nOf\tO\n18\tO\nconsecutive\tO\nreferrals\tO\nof\tO\nchildren\tO\nwith\tO\nresistant\tO\ntypical\tO\nabsences\tO\nonly\tO\n,\tO\neight\tO\nwere\tO\nerroneously\tO\ntreated\tO\nwith\tO\ncarbamazepine\tB-Chemical\neither\tO\nas\tO\nmonotherapy\tO\nor\tO\nas\tO\nan\tO\nadd\tO\n-\tO\non\tO\n.\tO\n\nVigabatrin\tB-Chemical\nwas\tO\nalso\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\ntwo\tO\nchildren\tO\n.\tO\n\nFrequency\tO\nof\tO\nabsences\tO\nincreased\tO\nin\tO\nfour\tO\nchildren\tO\ntreated\tO\nwith\tO\ncarbamazepine\tB-Chemical\nand\tO\ntwo\tO\nof\tO\nthese\tO\ndeveloped\tO\nmyoclonic\tB-Disease\njerks\tI-Disease\n,\tO\nwhich\tO\nresolved\tO\non\tO\nwithdrawal\tO\nof\tO\ncarbamazepine\tB-Chemical\n.\tO\n\nAbsences\tO\nwere\tO\naggravated\tO\nin\tO\nboth\tO\ncases\tO\nwhere\tO\nvigabatrin\tB-Chemical\nwas\tO\nadded\tO\non\tO\nto\tO\nconcurrent\tO\ntreatment\tO\n.\tO\n\nOptimal\tO\ncontrol\tO\nof\tO\nthe\tO\nabsences\tO\nwas\tO\nachieved\tO\nwith\tO\nsodium\tB-Chemical\nvalproate\tI-Chemical\n,\tO\nlamotrigine\tB-Chemical\n,\tO\nor\tO\nethosuximide\tB-Chemical\nalone\tO\nor\tO\nin\tO\ncombination\tO\n.\tO\n\nChoreoathetoid\tB-Disease\nmovements\tI-Disease\nassociated\tO\nwith\tO\nrapid\tO\nadjustment\tO\nto\tO\nmethadone\tB-Chemical\n.\tO\n\nChoreatiform\tB-Disease\nhyperkinesias\tI-Disease\nare\tO\nknown\tO\nto\tO\nbe\tO\noccasional\tO\nmovement\tB-Disease\nabnormalities\tI-Disease\nduring\tO\nintoxications\tO\nwith\tO\ncocaine\tB-Chemical\nbut\tO\nnot\tO\nopiates\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\ncase\tO\nreport\tO\nof\tO\neuphoria\tO\nand\tO\nchoreoathetoid\tB-Disease\nmovements\tI-Disease\nboth\tO\ntransiently\tO\ninduced\tO\nby\tO\nrapid\tO\nadjustment\tO\nto\tO\nthe\tO\nselective\tO\nmu\tO\n-\tO\nopioid\tO\nreceptor\tO\nagonist\tO\nmethadone\tB-Chemical\nin\tO\nan\tO\ninpatient\tO\npreviously\tO\nabusing\tO\nheroine\tB-Chemical\nand\tO\ncocaine\tB-Chemical\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nminor\tO\nEEG\tO\nabnormalities\tO\noccurred\tO\n.\tO\n\nPossible\tO\nunderlying\tO\nneurobiological\tO\nphenomena\tO\nare\tO\ndiscussed\tO\n.\tO\n\nAdverse\tO\neffects\tO\nof\tO\nthe\tO\natypical\tO\nantipsychotics\tO\n.\tO\n\nCollaborative\tO\nWorking\tO\nGroup\tO\non\tO\nClinical\tO\nTrial\tO\nEvaluations\tO\n.\tO\n\nAdverse\tO\neffects\tO\nof\tO\nantipsychotics\tO\noften\tO\nlead\tO\nto\tO\nnoncompliance\tO\n.\tO\n\nThus\tO\n,\tO\nclinicians\tO\nshould\tO\naddress\tO\npatients\tO\n'\tO\nconcerns\tO\nabout\tO\nadverse\tO\neffects\tO\nand\tO\nattempt\tO\nto\tO\nchoose\tO\nmedications\tO\nthat\tO\nwill\tO\nimprove\tO\ntheir\tO\npatients\tO\n'\tO\nquality\tO\nof\tO\nlife\tO\nas\tO\nwell\tO\nas\tO\noverall\tO\nhealth\tO\n.\tO\n\nThe\tO\nside\tO\neffect\tO\nprofiles\tO\nof\tO\nthe\tO\natypical\tO\nantipsychotics\tO\nare\tO\nmore\tO\nadvantageous\tO\nthan\tO\nthose\tO\nof\tO\nthe\tO\nconventional\tO\nneuroleptics\tO\n.\tO\n\nConventional\tO\nagents\tO\nare\tO\nassociated\tO\nwith\tO\nunwanted\tO\ncentral\tO\nnervous\tO\nsystem\tO\neffects\tO\n,\tO\nincluding\tO\nextrapyramidal\tB-Disease\nsymptoms\tI-Disease\n(\tO\nEPS\tB-Disease\n)\tO\n,\tO\ntardive\tB-Disease\ndyskinesia\tI-Disease\n,\tO\nsedation\tO\n,\tO\nand\tO\npossible\tO\nimpairment\tO\nof\tO\nsome\tO\ncognitive\tO\nmeasures\tO\n,\tO\nas\tO\nwell\tO\nas\tO\ncardiac\tO\neffects\tO\n,\tO\northostatic\tB-Disease\nhypotension\tI-Disease\n,\tO\nhepatic\tO\nchanges\tO\n,\tO\nanticholinergic\tO\nside\tO\neffects\tO\n,\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\n,\tO\nand\tO\nweight\tB-Disease\ngain\tI-Disease\n.\tO\n\nThe\tO\nnewer\tO\natypical\tO\nagents\tO\nhave\tO\na\tO\nlower\tO\nrisk\tO\nof\tO\nEPS\tB-Disease\n,\tO\nbut\tO\nare\tO\nassociated\tO\nin\tO\nvarying\tO\ndegrees\tO\nwith\tO\nsedation\tO\n,\tO\ncardiovascular\tO\neffects\tO\n,\tO\nanticholinergic\tO\neffects\tO\n,\tO\nweight\tB-Disease\ngain\tI-Disease\n,\tO\nsexual\tB-Disease\ndysfunction\tI-Disease\n,\tO\nhepatic\tO\neffects\tO\n,\tO\nlowered\tO\nseizure\tB-Disease\nthreshold\tO\n(\tO\nprimarily\tO\nclozapine\tB-Chemical\n)\tO\n,\tO\nand\tO\nagranulocytosis\tB-Disease\n(\tO\nclozapine\tB-Chemical\nonly\tO\n)\tO\n.\tO\n\nSince\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\nspecific\tO\nadverse\tO\neffects\tO\ndiffer\tO\namong\tO\nthe\tO\nvarious\tO\natypicals\tO\n,\tO\nthe\tO\nclinician\tO\nshould\tO\ncarefully\tO\nconsider\tO\nwhich\tO\nside\tO\neffects\tO\nare\tO\nmost\tO\nlikely\tO\nto\tO\nlead\tO\nto\tO\nthe\tO\nindividual\tO\n'\tO\ns\tO\ndissatisfaction\tO\nand\tO\nnoncompliance\tO\nbefore\tO\nchoosing\tO\nan\tO\nantipsychotic\tO\nfor\tO\na\tO\nparticular\tO\npatient\tO\n.\tO\n\nA\tO\nrandomized\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ndose\tO\n-\tO\ncomparison\tO\ntrial\tO\nof\tO\nhaloperidol\tB-Chemical\nfor\tO\npsychosis\tB-Disease\nand\tO\ndisruptive\tB-Disease\nbehaviors\tI-Disease\nin\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\ngoal\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ncompare\tO\nthe\tO\nefficacy\tO\nand\tO\nside\tO\neffects\tO\nof\tO\ntwo\tO\ndoses\tO\nof\tO\nhaloperidol\tB-Chemical\nand\tO\nplacebo\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\npsychosis\tB-Disease\nand\tO\ndisruptive\tB-Disease\nbehaviors\tI-Disease\nin\tO\npatients\tO\nwith\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nIn\tO\na\tO\n6\tO\n-\tO\nweek\tO\nrandom\tO\n-\tO\nassignment\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\nplacebo\tO\n-\tO\ncontrolled\tO\ntrial\tO\n(\tO\nphase\tO\nA\tO\n)\tO\n,\tO\nhaloperidol\tB-Chemical\n,\tO\n2\tO\n-\tO\n3\tO\nmg\tO\n/\tO\nday\tO\n(\tO\nstandard\tO\ndose\tO\n)\tO\n,\tO\nand\tO\nhaloperidol\tB-Chemical\n,\tO\n0\tO\n.\tO\n50\tO\n-\tO\n0\tO\n.\tO\n75\tO\nmg\tO\n/\tO\nday\tO\n(\tO\nlow\tO\ndose\tO\n)\tO\n,\tO\nwere\tO\ncompared\tO\nin\tO\n71\tO\noutpatients\tO\nwith\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n.\tO\n\nFor\tO\nthe\tO\nsubsequent\tO\n6\tO\n-\tO\nweek\tO\ndouble\tO\n-\tO\nblind\tO\ncrossover\tO\nphase\tO\n(\tO\nphase\tO\nB\tO\n)\tO\n,\tO\npatients\tO\ntaking\tO\nstandard\tO\n-\tO\nor\tO\nlow\tO\n-\tO\ndose\tO\nhaloperidol\tB-Chemical\nwere\tO\nswitched\tO\nto\tO\nplacebo\tO\n,\tO\nand\tO\npatients\tO\ntaking\tO\nplacebo\tO\nwere\tO\nrandomly\tO\nassigned\tO\nto\tO\nstandard\tO\n-\tO\nor\tO\nlow\tO\n-\tO\ndose\tO\nhaloperidol\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nFor\tO\nthe\tO\n60\tO\npatients\tO\nwho\tO\ncompleted\tO\nphase\tO\nA\tO\n,\tO\nstandard\tO\n-\tO\ndose\tO\nhaloperidol\tB-Chemical\nwas\tO\nefficacious\tO\nand\tO\nsuperior\tO\nto\tO\nboth\tO\nlow\tO\n-\tO\ndose\tO\nhaloperidol\tB-Chemical\nand\tO\nplacebo\tO\nfor\tO\nscores\tO\non\tO\nthe\tO\nBrief\tO\nPsychiatric\tO\nRating\tO\nScale\tO\npsychosis\tB-Disease\nfactor\tO\nand\tO\non\tO\npsychomotor\tB-Disease\nagitation\tI-Disease\n.\tO\n\nResponse\tO\nrates\tO\naccording\tO\nto\tO\nthree\tO\nsets\tO\nof\tO\ncriteria\tO\nwere\tO\ngreater\tO\nwith\tO\nthe\tO\nstandard\tO\ndose\tO\n(\tO\n55\tO\n%\tO\n-\tO\n60\tO\n%\tO\n)\tO\nthan\tO\nthe\tO\nlow\tO\ndose\tO\n(\tO\n25\tO\n%\tO\n-\tO\n35\tO\n%\tO\n)\tO\nand\tO\nplacebo\tO\n(\tO\n25\tO\n%\tO\n-\tO\n30\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nadvantage\tO\nof\tO\nstandard\tO\ndose\tO\nover\tO\nlow\tO\ndose\tO\nwas\tO\nreplicated\tO\nin\tO\nphase\tO\nB\tO\n.\tO\n\nIn\tO\nphase\tO\nA\tO\n,\tO\nextrapyramidal\tB-Disease\nsigns\tI-Disease\ntended\tO\nto\tO\nbe\tO\ngreater\tO\nwith\tO\nthe\tO\nstandard\tO\ndose\tO\nthan\tO\nin\tO\nthe\tO\nother\tO\ntwo\tO\nconditions\tO\n,\tO\nprimarily\tO\nbecause\tO\nof\tO\na\tO\nsubgroup\tO\n(\tO\n20\tO\n%\tO\n)\tO\nwho\tO\ndeveloped\tO\nmoderate\tO\nto\tO\nsevere\tO\nsigns\tO\n.\tO\n\nLow\tO\n-\tO\ndose\tO\nhaloperidol\tB-Chemical\ndid\tO\nnot\tO\ndiffer\tO\nfrom\tO\nplacebo\tO\non\tO\nany\tO\nmeasure\tO\nof\tO\nefficacy\tO\nor\tO\nside\tO\neffects\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\nresults\tO\nindicated\tO\na\tO\nfavorable\tO\ntherapeutic\tO\nprofile\tO\nfor\tO\nhaloperidol\tB-Chemical\nin\tO\ndoses\tO\nof\tO\n2\tO\n-\tO\n3\tO\nmg\tO\n/\tO\nday\tO\n,\tO\nalthough\tO\na\tO\nsubgroup\tO\ndeveloped\tO\nmoderate\tO\nto\tO\nsevere\tO\nextrapyramidal\tB-Disease\nsigns\tI-Disease\n.\tO\n\nA\tO\nstarting\tO\ndose\tO\nof\tO\n1\tO\nmg\tO\n/\tO\nday\tO\nwith\tO\ngradual\tO\n,\tO\nupward\tO\ndose\tO\ntitration\tO\nis\tO\nrecommended\tO\n.\tO\n\nThe\tO\nnarrow\tO\ntherapeutic\tO\nwindow\tO\nobserved\tO\nwith\tO\nhaloperidol\tB-Chemical\nmay\tO\nalso\tO\napply\tO\nto\tO\nother\tO\nneuroleptics\tO\nused\tO\nin\tO\nAlzheimer\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\npatients\tO\nwith\tO\npsychosis\tB-Disease\nand\tO\ndisruptive\tB-Disease\nbehaviors\tI-Disease\n.\tO\n\nEffects\tO\nof\tO\nacetylsalicylic\tB-Chemical\nacid\tI-Chemical\n,\tO\ndipyridamole\tB-Chemical\n,\tO\nand\tO\nhydrocortisone\tB-Chemical\non\tO\nepinephrine\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\nin\tO\ndogs\tO\n.\tO\n\nA\tO\nreproducible\tO\nmodel\tO\nfor\tO\nproducing\tO\ndiffuse\tO\nmyocardial\tB-Disease\ninjury\tI-Disease\n(\tO\nepinephrine\tB-Chemical\ninfusion\tO\n)\tO\nhas\tO\nbeen\tO\ndeveloped\tO\nto\tO\nstudy\tO\nthe\tO\ncardioprotective\tO\neffects\tO\nof\tO\nagents\tO\nor\tO\nmaneuvers\tO\nwhich\tO\nmight\tO\nalter\tO\nthe\tO\nevolution\tO\nof\tO\nacute\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nInfusions\tO\nof\tO\nepinephrine\tB-Chemical\n(\tO\n4\tO\nmug\tO\nper\tO\nkilogram\tO\nper\tO\nminute\tO\nfor\tO\n6\tO\nhours\tO\n)\tO\nincreased\tO\nradiocalcium\tB-Chemical\nuptakes\tO\ninto\tO\nintact\tO\nmyocardium\tO\nand\tO\neach\tO\nof\tO\nits\tO\nsubcellular\tO\ncomponents\tO\nwith\tO\nthe\tO\nmitochondrial\tO\nfraction\tO\nshowing\tO\nthe\tO\nmost\tO\nconsistent\tO\nchanges\tO\nwhen\tO\ncompared\tO\nto\tO\nsaline\tO\n-\tO\ninfused\tO\ncontrol\tO\nanimals\tO\n(\tO\n4\tO\n,\tO\n957\tO\nvs\tO\n.\tO\n827\tO\ncounts\tO\nper\tO\nminute\tO\nper\tO\ngram\tO\nof\tO\ndried\tO\ntissue\tO\nor\tO\nfraction\tO\n)\tO\n.\tO\n\nMyocardial\tO\nconcentrations\tO\nof\tO\ncalcium\tB-Chemical\nalso\tO\nincreased\tO\nsignificantly\tO\n(\tO\n12\tO\n.\tO\n0\tO\nvs\tO\n.\tO\n5\tO\n.\tO\n0\tO\nmg\tO\n.\tO\nper\tO\n100\tO\nGm\tO\n.\tO\nof\tO\nfat\tO\n-\tO\nfree\tO\ndry\tO\nweight\tO\n)\tO\n.\tO\n\nInfusions\tO\nof\tO\ncalcium\tB-Chemical\nchloride\tI-Chemical\nsufficient\tO\nto\tO\nraise\tO\nserum\tO\ncalcium\tB-Chemical\nconcentrations\tO\n2\tO\nmEq\tO\n.\tO\nper\tO\nliter\tO\nfailed\tO\nto\tO\nincrease\tO\ncalcium\tB-Chemical\ninflux\tO\ninto\tO\nthe\tO\nmyocardial\tO\ncell\tO\n.\tO\n\nMitochondrial\tO\nradiocalcium\tB-Chemical\nuptakes\tO\nwere\tO\nsignificantly\tO\ndecreased\tO\nin\tO\nanimals\tO\npretreated\tO\nwith\tO\nacetylsalicylic\tB-Chemical\nacid\tI-Chemical\nor\tO\ndipyridamole\tB-Chemical\nor\tO\nwhen\tO\nhydrocortisone\tB-Chemical\nwas\tO\nadded\tO\nto\tO\nthe\tO\nepinephrine\tB-Chemical\ninfusion\tO\n(\tO\n2\tO\n,\tO\n682\tO\n,\tO\n2\tO\n,\tO\n803\tO\n,\tO\nand\tO\n3\tO\n,\tO\n424\tO\ncounts\tO\nper\tO\nminute\tO\nper\tO\ngram\tO\nof\tO\ndried\tO\nfraction\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nMyocardial\tO\ncalcium\tB-Chemical\nconcentrations\tO\nalso\tO\nwere\tO\ndecreased\tO\n(\tO\n11\tO\n.\tO\n2\tO\n,\tO\n8\tO\n.\tO\n3\tO\n,\tO\nand\tO\n8\tO\n.\tO\n9\tO\nmg\tO\n.\tO\nper\tO\n100\tO\nGm\tO\n.\tO\nof\tO\nfat\tO\n-\tO\nfree\tO\ndry\tO\nweight\tO\n,\tO\nrespectively\tO\n)\tO\nin\tO\nthe\tO\nthree\tO\ntreatment\tO\ngroups\tO\n,\tO\nbeing\tO\nsignificantly\tO\ndecreased\tO\nonly\tO\nin\tO\nthe\tO\nlast\tO\ntwo\tO\n.\tO\n\nEvidence\tO\nof\tO\nmicroscopic\tO\ndamage\tO\nwas\tO\ngraded\tO\nas\tO\nless\tO\nsevere\tO\nin\tO\nthe\tO\nthree\tO\ntreatment\tO\ngroups\tO\n.\tO\n\nAcetylsalicylic\tB-Chemical\nacid\tI-Chemical\n,\tO\ndipyridamole\tB-Chemical\n,\tO\nand\tO\nhydrocortisone\tB-Chemical\nall\tO\nappear\tO\nto\tO\nhave\tO\ncardioprotective\tO\neffects\tO\nwhen\tO\ntested\tO\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nClinical\tO\nand\tO\nhistopathologic\tO\nexamination\tO\nof\tO\nrenal\tO\nallografts\tO\ntreated\tO\nwith\tO\ntacrolimus\tB-Chemical\n(\tO\nFK506\tB-Chemical\n)\tO\nfor\tO\nat\tO\nleast\tO\none\tO\nyear\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nWe\tO\nclinically\tO\nand\tO\npathologically\tO\nanalyzed\tO\nrenal\tO\nallografts\tO\nfrom\tO\n1\tO\n9\tO\nrenal\tO\ntransplant\tO\npatients\tO\ntreated\tO\nwith\tO\ntacrolimus\tB-Chemical\n(\tO\nFK506\tB-Chemical\n)\tO\nfor\tO\nmore\tO\nthan\tO\n1\tO\nyear\tO\n.\tO\n\nMETHODS\tO\n:\tO\nTwenty\tO\n-\tO\nsix\tO\nrenal\tO\nallograft\tO\nbiopsy\tO\nspecimens\tO\nfrom\tO\n1\tO\n9\tO\nrenal\tO\ntransplant\tO\npatients\tO\nwho\tO\nunderwent\tO\ntransplantations\tO\nbetween\tO\n1991\tO\nand\tO\n1993\tO\nwere\tO\nevaluated\tO\n.\tO\n\nThirteen\tO\nbiopsies\tO\nwere\tO\nperformed\tO\nfrom\tO\nstable\tO\nfunctioning\tO\nrenal\tO\nallografts\tO\nwith\tO\ninformed\tO\nconsent\tO\n(\tO\nnonepisode\tO\nbiopsy\tO\n)\tO\nand\tO\nthe\tO\nother\tO\n13\tO\nwere\tO\nfrom\tO\ndysfunctional\tO\nrenal\tO\nallografts\tO\nwith\tO\na\tO\nclinical\tO\nindication\tO\nfor\tO\nbiopsy\tO\n(\tO\nepisode\tO\nbiopsy\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nmain\tO\npathologic\tO\ndiagnoses\tO\n(\tO\nsome\tO\noverlap\tO\n)\tO\nwere\tO\nacute\tO\nrejection\tO\n(\tO\nAR\tO\n;\tO\nn\tO\n=\tO\n4\tO\n)\tO\n,\tO\nchronic\tO\nrejection\tO\n(\tO\nCR\tO\n;\tO\nn\tO\n=\tO\n5\tO\n)\tO\n,\tO\nAR\tO\n+\tO\nCR\tO\n(\tO\nn\tO\n=\tO\n4\tO\n)\tO\n,\tO\nrecurrent\tO\nIgA\tB-Disease\nnephropathy\tI-Disease\n(\tO\nn\tO\n=\tO\n5\tO\n)\tO\n,\tO\nnormal\tO\nfindings\tO\n(\tO\nn\tO\n=\tO\n2\tO\n)\tO\n,\tO\nminimal\tO\n-\tO\ntype\tO\nchronic\tO\nFK506\tB-Chemical\nnephropathy\tB-Disease\n(\tO\nn\tO\n=\tO\n9\tO\n)\tO\n,\tO\nand\tO\nmild\tO\n-\tO\ntype\tO\nFK506\tB-Chemical\nnephropathy\tB-Disease\n(\tO\nn\tO\n=\tO\n11\tO\n)\tO\n.\tO\n\nOf\tO\nthe\tO\nnonepisode\tO\nbiopsies\tO\n,\tO\n7\tO\nand\tO\n4\tO\nbiopsies\tO\nshowed\tO\nminimal\tO\n-\tO\ntype\tO\nand\tO\nmild\tO\n-\tO\ntype\tO\nchronic\tO\nFK506\tB-Chemical\nnephropathy\tB-Disease\n,\tO\nrespectively\tO\n.\tO\n\nChronic\tO\nFK506\tB-Chemical\nnephropathy\tB-Disease\nconsisted\tO\nof\tO\nrough\tO\nand\tO\nfoamy\tO\ntubular\tO\nvacuolization\tO\n(\tO\n5\tO\nbiopsies\tO\n)\tO\n,\tO\narteriolopathy\tO\n(\tO\nangiodegeneration\tO\nof\tO\nthe\tO\narteriolar\tO\nwall\tO\n;\tO\n20\tO\nbiopsies\tO\n)\tO\n,\tO\nfocal\tB-Disease\nsegmental\tI-Disease\nglomerulosclerosis\tI-Disease\n(\tO\n4\tO\nbiopsies\tO\n)\tO\nand\tO\nthe\tO\nstriped\tO\nform\tO\nof\tO\ninterstitial\tB-Disease\nfibrosis\tI-Disease\n(\tO\n11\tO\nbiopsies\tO\n)\tO\n.\tO\n\nThe\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\nof\tO\npatients\tO\nin\tO\nthe\tO\nmild\tO\n-\tO\ntype\tO\nchronic\tO\nFK506\tB-Chemical\nnephropathy\tB-Disease\ngroup\tO\n,\tO\nwhich\tO\nincluded\tO\n7\tO\nepisode\tO\nbiopsies\tO\n,\tO\nwere\tO\nstatistically\tO\nhigher\tO\nthan\tO\nthose\tO\nin\tO\nthe\tO\nminimum\tO\n-\tO\ntype\tO\nchronic\tO\nFK506\tB-Chemical\n-\tO\nnephropathy\tB-Disease\ngroup\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThis\tO\nstudy\tO\ndemonstrates\tO\nthat\tO\nchronic\tO\nFK506\tB-Chemical\nnephropathy\tB-Disease\nconsists\tO\nprimarily\tO\nof\tO\narteriolopathy\tO\nmanifesting\tO\nas\tO\ninsudative\tO\nhyalinosis\tO\nof\tO\nthe\tO\narteriolar\tO\nwall\tO\n,\tO\nand\tO\nsuggests\tO\nthat\tO\nmild\tO\n-\tO\ntype\tO\nchronic\tO\nFK506\tB-Chemical\nnephropathy\tB-Disease\nis\tO\na\tO\ncondition\tO\nwhich\tO\nmay\tO\nlead\tO\nto\tO\ndeterioration\tO\nof\tO\nrenal\tO\nallograft\tO\nfunction\tO\n.\tO\n\nDifferent\tO\nlobular\tO\ndistributions\tO\nof\tO\naltered\tO\nhepatocyte\tO\ntight\tO\njunctions\tO\nin\tO\nrat\tO\nmodels\tO\nof\tO\nintrahepatic\tB-Disease\nand\tI-Disease\nextrahepatic\tI-Disease\ncholestasis\tI-Disease\n.\tO\n\nHepatocyte\tO\ntight\tO\njunctions\tO\n(\tO\nTJs\tO\n)\tO\n,\tO\nthe\tO\nonly\tO\nintercellular\tO\nbarrier\tO\nbetween\tO\nthe\tO\nsinusoidal\tO\nand\tO\nthe\tO\ncanalicular\tO\nspaces\tO\n,\tO\nplay\tO\na\tO\nkey\tO\nrole\tO\nin\tO\nbile\tO\nformation\tO\n.\tO\n\nAlthough\tO\nhepatocyte\tO\nTJs\tO\nare\tO\nimpaired\tO\nin\tO\ncholestasis\tB-Disease\n,\tO\nattempts\tO\nto\tO\nlocalize\tO\nthe\tO\nprecise\tO\nsite\tO\nof\tO\nhepatocyte\tO\nTJ\tO\ndamage\tO\nby\tO\nfreeze\tO\n-\tO\nfracture\tO\nelectron\tO\nmicroscopy\tO\nhave\tO\nproduced\tO\nlimited\tO\ninformation\tO\n.\tO\n\nRecently\tO\n,\tO\nseveral\tO\nTJ\tO\n-\tO\nassociated\tO\nproteins\tO\nlike\tO\nZO\tO\n-\tO\n1\tO\nand\tO\n7H6\tO\nhave\tO\nbeen\tO\nidentified\tO\nand\tO\ncharacterized\tO\n.\tO\n\nImmunolocalization\tO\nof\tO\n7H6\tO\nappears\tO\nto\tO\nclosely\tO\ncorrelate\tO\nwith\tO\nparacellular\tO\npermeability\tO\n.\tO\n\nWe\tO\nused\tO\nrat\tO\nmodels\tO\nof\tO\nintrahepatic\tB-Disease\ncholestasis\tI-Disease\nby\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n(\tO\nEE\tB-Chemical\n)\tO\ntreatment\tO\nand\tO\nextrahepatic\tB-Disease\ncholestasis\tI-Disease\nby\tO\nbile\tO\nduct\tO\nligation\tO\n(\tO\nBDL\tO\n)\tO\nto\tO\nprecisely\tO\ndetermine\tO\nthe\tO\nsite\tO\nof\tO\nTJ\tO\ndamage\tO\n.\tO\n\nAlterations\tO\nin\tO\nhepatocyte\tO\nTJs\tO\nwere\tO\nassessed\tO\nby\tO\ndouble\tO\n-\tO\nimmunolabeling\tO\nfor\tO\n7H6\tO\nand\tO\nZO\tO\n-\tO\n1\tO\nusing\tO\na\tO\nconfocal\tO\nlaser\tO\nscanning\tO\nmicroscope\tO\n.\tO\n\nIn\tO\ncontrol\tO\nrats\tO\n,\tO\nimmunostaining\tO\nfor\tO\n7H6\tO\nand\tO\nZO\tO\n-\tO\n1\tO\ncolocalized\tO\nto\tO\noutline\tO\nbile\tO\ncanaliculi\tO\nin\tO\na\tO\ncontinuous\tO\nfashion\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\n7H6\tO\nand\tO\nZO\tO\n-\tO\n1\tO\nimmunostaining\tO\nwas\tO\nmore\tO\ndiscontinuous\tO\n,\tO\noutlining\tO\nthe\tO\nbile\tO\ncanaliculi\tO\nafter\tO\nBDL\tO\n.\tO\n\nImmunostaining\tO\nfor\tO\n7H6\tO\n,\tO\nnot\tO\nZO\tO\n-\tO\n1\tO\n,\tO\ndecreased\tO\nand\tO\npredominantly\tO\nappeared\tO\nas\tO\ndiscrete\tO\nsignals\tO\nin\tO\nthe\tO\nsubmembranous\tO\ncytoplasm\tO\nof\tO\nperiportal\tO\nhepatocytes\tO\nafter\tO\nBDL\tO\n.\tO\n\nAfter\tO\nEE\tB-Chemical\ntreatment\tO\n,\tO\nchanges\tO\nin\tO\nimmunostaining\tO\nfor\tO\n7H6\tO\nand\tO\nZO\tO\n-\tO\n1\tO\nwere\tO\nsimilar\tO\nto\tO\nthose\tO\nseen\tO\nin\tO\nperiportal\tO\nhepatocytes\tO\nafter\tO\nBDL\tO\n,\tO\nbut\tO\ndistributed\tO\nmore\tO\ndiffusely\tO\nthroughout\tO\nthe\tO\nlobule\tO\n.\tO\n\nThis\tO\nstudy\tO\nis\tO\nthe\tO\nfirst\tO\nto\tO\ndemonstrate\tO\nthat\tO\nimpairment\tO\nof\tO\nhepatocyte\tO\nTJs\tO\noccurs\tO\nheterogenously\tO\nin\tO\nthe\tO\nliver\tO\nlobule\tO\nafter\tO\nBDL\tO\nand\tO\nsuggests\tO\nthat\tO\nBDL\tO\nand\tO\nEE\tB-Chemical\ntreatments\tO\nproduce\tO\ndifferent\tO\nlobular\tO\ndistributions\tO\nof\tO\nincreased\tO\nparacellular\tO\npermeability\tO\n.\tO\n\nMemory\tO\nfacilitation\tO\nand\tO\nstimulation\tO\nof\tO\nendogenous\tO\nnerve\tO\ngrowth\tO\nfactor\tO\nsynthesis\tO\nby\tO\nthe\tO\nacetylcholine\tB-Chemical\nreleaser\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\n.\tO\n\nThe\tO\neffects\tO\nof\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\n(\tO\n3alpha\tB-Chemical\n-\tI-Chemical\ntropyl\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\np\tI-Chemical\n-\tI-Chemical\nbromophenyl\tI-Chemical\n)\tI-Chemical\npropionate\tI-Chemical\n)\tO\n,\tO\nthe\tO\nacetylcholine\tB-Chemical\nreleaser\tO\n,\tO\non\tO\nmemory\tO\nprocesses\tO\nand\tO\nnerve\tO\ngrowth\tO\nfactor\tO\n(\tO\nNGF\tO\n)\tO\nsynthesis\tO\nwere\tO\nevaluated\tO\n.\tO\n\nIn\tO\nthe\tO\nmouse\tO\npassive\tO\n-\tO\navoidance\tO\ntest\tO\n,\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\n(\tO\n10\tO\n-\tO\n30\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\nadministered\tO\n20\tO\nmin\tO\nbefore\tO\nthe\tO\ntraining\tO\nsession\tO\n,\tO\nprevented\tO\namnesia\tB-Disease\ninduced\tO\nby\tO\nboth\tO\nthe\tO\nnon\tO\nselective\tO\nantimuscarinic\tO\ndrug\tO\nscopolamine\tB-Chemical\nand\tO\nthe\tO\nM1\tO\n-\tO\nselective\tO\nantagonist\tO\nS\tB-Chemical\n-\tI-Chemical\n(\tI-Chemical\n-\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nET\tI-Chemical\n-\tI-Chemical\n126\tI-Chemical\n.\tO\n\nIn\tO\nthe\tO\nsame\tO\nexperimental\tO\nconditions\tO\n,\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\n(\tO\n5\tO\n-\tO\n20\tO\nmicrog\tO\nper\tO\nmouse\tO\n,\tO\ni\tO\n.\tO\nc\tO\n.\tO\nv\tO\n.\tO\n)\tO\nwas\tO\nalso\tO\nable\tO\nto\tO\nprevent\tO\nantimuscarine\tO\n-\tO\ninduced\tO\namnesia\tB-Disease\n,\tO\ndemonstrating\tO\na\tO\ncentral\tO\nlocalization\tO\nof\tO\nthe\tO\nactivity\tO\n.\tO\n\nAt\tO\nthe\tO\nhighest\tO\neffective\tO\ndoses\tO\n,\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\ndid\tO\nnot\tO\nproduce\tO\nany\tO\ncollateral\tO\nsymptoms\tO\nas\tO\nrevealed\tO\nby\tO\nthe\tO\nIrwin\tO\ntest\tO\n,\tO\nand\tO\nit\tO\ndid\tO\nnot\tO\nmodify\tO\nspontaneous\tO\nmotility\tO\nand\tO\ninspection\tO\nactivity\tO\n,\tO\nas\tO\nrevealed\tO\nby\tO\nthe\tO\nhole\tO\n-\tO\nboard\tO\ntest\tO\n.\tO\n\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\nwas\tO\nalso\tO\nable\tO\nto\tO\nincrease\tO\nthe\tO\namount\tO\nof\tO\nNGF\tO\nsecreted\tO\nin\tO\nvitro\tO\nby\tO\nastrocytes\tO\nin\tO\na\tO\ndose\tO\n-\tO\ndependent\tO\nmanner\tO\n.\tO\n\nThe\tO\nmaximal\tO\nNGF\tO\ncontents\tO\nobtained\tO\nby\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\nwere\tO\n17\tO\n.\tO\n6\tO\n-\tO\nfold\tO\nof\tO\nthe\tO\ncontrol\tO\nvalue\tO\n.\tO\n\nDuring\tO\nculture\tO\n,\tO\nno\tO\nmorphological\tO\nchanges\tO\nwere\tO\nfound\tO\nat\tO\neffective\tO\nconcentrations\tO\nof\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\n.\tO\n\nThe\tO\ncurrent\tO\nwork\tO\nindicates\tO\nthe\tO\nability\tO\nof\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\nto\tO\ninduce\tO\nbeneficial\tO\neffects\tO\non\tO\ncognitive\tO\nprocesses\tO\nand\tO\nstimulate\tO\nactivity\tO\nof\tO\nNGF\tO\nsynthesis\tO\nin\tO\nastroglial\tO\ncells\tO\n.\tO\n\nTherefore\tO\n,\tO\nPG\tB-Chemical\n-\tI-Chemical\n9\tI-Chemical\ncould\tO\nrepresent\tO\na\tO\npotential\tO\nuseful\tO\ndrug\tO\nable\tO\nto\tO\nimprove\tO\nthe\tO\nfunction\tO\nof\tO\nimpaired\tO\ncognitive\tO\nprocesses\tO\n.\tO\n\nMechanisms\tO\nof\tO\nFK\tB-Chemical\n506\tI-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\n-\tO\nTacrolimus\tB-Chemical\n(\tO\nFK\tB-Chemical\n506\tI-Chemical\n)\tO\nis\tO\na\tO\npowerful\tO\n,\tO\nwidely\tO\nused\tO\nimmunosuppressant\tO\n.\tO\n\nThe\tO\nclinical\tO\nutility\tO\nof\tO\nFK\tB-Chemical\n506\tI-Chemical\nis\tO\ncomplicated\tO\nby\tO\nsubstantial\tO\nhypertension\tB-Disease\nand\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nTo\tO\nclarify\tO\nthe\tO\nmechanisms\tO\nof\tO\nFK\tB-Chemical\n506\tI-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nchronic\tO\neffects\tO\nof\tO\nFK\tB-Chemical\n506\tI-Chemical\non\tO\nthe\tO\nsynthesis\tO\nof\tO\nendothelin\tO\n-\tO\n1\tO\n(\tO\nET\tO\n-\tO\n1\tO\n)\tO\n,\tO\nthe\tO\nexpression\tO\nof\tO\nmRNA\tO\nof\tO\nET\tO\n-\tO\n1\tO\nand\tO\nendothelin\tO\n-\tO\nconverting\tO\nenzyme\tO\n-\tO\n1\tO\n(\tO\nECE\tO\n-\tO\n1\tO\n)\tO\n,\tO\nthe\tO\nendothelial\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsynthase\tO\n(\tO\neNOS\tO\n)\tO\nactivity\tO\n,\tO\nand\tO\nthe\tO\nexpression\tO\nof\tO\nmRNA\tO\nof\tO\neNOS\tO\nand\tO\nC\tO\n-\tO\ntype\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nCNP\tO\n)\tO\nin\tO\nrat\tO\nblood\tO\nvessels\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthe\tO\neffect\tO\nof\tO\nthe\tO\nspecific\tO\nendothelin\tO\ntype\tO\nA\tO\nreceptor\tO\nantagonist\tO\nFR\tB-Chemical\n139317\tI-Chemical\non\tO\nFK\tB-Chemical\n506\tI-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nrats\tO\nwas\tO\nstudied\tO\n.\tO\n\nFK\tB-Chemical\n506\tI-Chemical\n,\tO\n5\tO\nmg\tO\n.\tO\n\nkg\tO\n-\tO\n1\tO\n.\tO\n\nd\tO\n-\tO\n1\tO\ngiven\tO\nfor\tO\n4\tO\nweeks\tO\n,\tO\nelevated\tO\nblood\tO\npressure\tO\nfrom\tO\n102\tO\n+\tO\n/\tO\n-\tO\n13\tO\nto\tO\n152\tO\n+\tO\n/\tO\n-\tO\n15\tO\nmm\tO\nHg\tO\nand\tO\nincreased\tO\nthe\tO\nsynthesis\tO\nof\tO\nET\tO\n-\tO\n1\tO\nand\tO\nthe\tO\nlevels\tO\nof\tO\nET\tO\n-\tO\n1\tO\nmRNA\tO\nin\tO\nthe\tO\nmesenteric\tO\nartery\tO\n(\tO\n240\tO\n%\tO\nand\tO\n230\tO\n%\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nLittle\tO\nchange\tO\nwas\tO\nobserved\tO\nin\tO\nthe\tO\nexpression\tO\nof\tO\nECE\tO\n-\tO\n1\tO\nmRNA\tO\nand\tO\nCNP\tO\nmRNA\tO\n.\tO\n\nFK\tB-Chemical\n506\tI-Chemical\ndecreased\tO\neNOS\tO\nactivity\tO\nand\tO\nthe\tO\nlevels\tO\nof\tO\neNOS\tO\nmRNA\tO\nin\tO\nthe\tO\naorta\tO\n(\tO\n48\tO\n%\tO\nand\tO\n55\tO\n%\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nFR\tB-Chemical\n139317\tI-Chemical\n(\tO\n10\tO\nmg\tO\n.\tO\nkg\tO\n-\tO\n1\tO\n.\tO\nd\tO\n-\tO\n1\tO\n)\tO\nprevented\tO\nFK\tB-Chemical\n506\tI-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nThese\tO\nresults\tO\nindicate\tO\nthat\tO\nFK\tB-Chemical\n506\tI-Chemical\nmay\tO\nincrease\tO\nblood\tO\npressure\tO\nnot\tO\nonly\tO\nby\tO\nincreasing\tO\nET\tO\n-\tO\n1\tO\nproduction\tO\nbut\tO\nalso\tO\nby\tO\ndecreasing\tO\nNO\tB-Chemical\nsynthesis\tO\nin\tO\nthe\tO\nvasculature\tO\n.\tO\n\n"
  },
  {
    "path": "dataset/BC5CDR/train_20.txt",
    "content": "Selegiline\tB-Chemical\n-\tO\ninduced\tO\npostural\tB-Disease\nhypotension\tI-Disease\nin\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n:\tO\na\tO\nlongitudinal\tO\nstudy\tO\non\tO\nthe\tO\neffects\tO\nof\tO\ndrug\tO\nwithdrawal\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nUnited\tO\nKingdom\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nResearch\tO\nGroup\tO\n(\tO\nUKPDRG\tO\n)\tO\ntrial\tO\nfound\tO\nan\tO\nincreased\tO\nmortality\tO\nin\tO\npatients\tO\nwith\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tB-Disease\n)\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tO\nmg\tO\nselegiline\tB-Chemical\nper\tO\nday\tO\nand\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\ncompared\tO\nwith\tO\nthose\tO\ntaking\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nalone\tO\n.\tO\n\nRecently\tO\n,\tO\nwe\tO\nfound\tO\nthat\tO\ntherapy\tO\nwith\tO\nselegiline\tB-Chemical\nand\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nwas\tO\nassociated\tO\nwith\tO\nselective\tO\nsystolic\tB-Disease\northostatic\tI-Disease\nhypotension\tI-Disease\nwhich\tO\nwas\tO\nabolished\tO\nby\tO\nwithdrawal\tO\nof\tO\nselegiline\tB-Chemical\n.\tO\n\nThe\tO\naims\tO\nof\tO\nthis\tO\nstudy\tO\nwere\tO\nto\tO\nconfirm\tO\nour\tO\nprevious\tO\nfindings\tO\nin\tO\na\tO\nseparate\tO\ncohort\tO\nof\tO\npatients\tO\nand\tO\nto\tO\ndetermine\tO\nthe\tO\ntime\tO\ncourse\tO\nof\tO\nthe\tO\ncardiovascular\tO\nconsequences\tO\nof\tO\nstopping\tO\nselegiline\tB-Chemical\nin\tO\nthe\tO\nexpectation\tO\nthat\tO\nthis\tO\nmight\tO\nshed\tO\nlight\tO\non\tO\nthe\tO\nmechanisms\tO\nby\tO\nwhich\tO\nthe\tO\ndrug\tO\ncauses\tO\northostatic\tB-Disease\nhypotension\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\ncardiovascular\tO\nresponses\tO\nto\tO\nstanding\tO\nand\tO\nhead\tO\n-\tO\nup\tO\ntilt\tO\nwere\tO\nstudied\tO\nrepeatedly\tO\nin\tO\nPD\tB-Disease\npatients\tO\nreceiving\tO\nselegiline\tB-Chemical\nand\tO\nas\tO\nthe\tO\ndrug\tO\nwas\tO\nwithdrawn\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHead\tO\n-\tO\nup\tO\ntilt\tO\ncaused\tO\nsystolic\tB-Disease\northostatic\tI-Disease\nhypotension\tI-Disease\nwhich\tO\nwas\tO\nmarked\tO\nin\tO\nsix\tO\nof\tO\n20\tO\nPD\tB-Disease\npatients\tO\non\tO\nselegiline\tB-Chemical\n,\tO\none\tO\nof\tO\nwhom\tO\nlost\tO\nconsciousness\tO\nwith\tO\nunrecordable\tO\nblood\tO\npressures\tO\n.\tO\n\nA\tO\nlesser\tO\ndegree\tO\nof\tO\northostatic\tB-Disease\nhypotension\tI-Disease\noccurred\tO\nwith\tO\nstanding\tO\n.\tO\n\nOrthostatic\tB-Disease\nhypotension\tI-Disease\nwas\tO\nameliorated\tO\n4\tO\ndays\tO\nafter\tO\nwithdrawal\tO\nof\tO\nselegiline\tB-Chemical\nand\tO\ntotally\tO\nabolished\tO\n7\tO\ndays\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nStopping\tO\nselegiline\tB-Chemical\nalso\tO\nsignificantly\tO\nreduced\tB-Disease\nthe\tI-Disease\nsupine\tI-Disease\nsystolic\tI-Disease\nand\tI-Disease\ndiastolic\tI-Disease\nblood\tI-Disease\npressures\tI-Disease\nconsistent\tO\nwith\tO\na\tO\npreviously\tO\nundescribed\tO\nsupine\tO\npressor\tO\naction\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nstudy\tO\nconfirms\tO\nour\tO\nprevious\tO\nfinding\tO\nthat\tO\nselegiline\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nis\tO\nassociated\tO\nwith\tO\nselective\tO\northostatic\tB-Disease\nhypotension\tI-Disease\n.\tO\n\nThe\tO\npossibilities\tO\nthat\tO\nthese\tO\ncardiovascular\tO\nfindings\tO\nmight\tO\nbe\tO\nthe\tO\nresult\tO\nof\tO\nnon\tO\n-\tO\nselective\tO\ninhibition\tO\nof\tO\nmonoamine\tO\noxidase\tO\nor\tO\nof\tO\namphetamine\tB-Chemical\nand\tO\nmetamphetamine\tB-Chemical\nare\tO\ndiscussed\tO\n.\tO\n\nThe\tO\nresults\tO\nhave\tO\nshown\tO\nthat\tO\nthe\tO\ndegradation\tO\nproduct\tO\np\tB-Chemical\n-\tI-Chemical\ncholoroaniline\tI-Chemical\nis\tO\nnot\tO\na\tO\nsignificant\tO\nfactor\tO\nin\tO\nchlorhexidine\tB-Chemical\n-\tI-Chemical\ndigluconate\tI-Chemical\nassociated\tO\nerosive\tO\ncystitis\tB-Disease\n.\tO\n\nA\tO\nhigh\tO\npercentage\tO\nof\tO\nkanamycin\tB-Chemical\n-\tO\ncolistin\tB-Chemical\nand\tO\npovidone\tB-Chemical\n-\tI-Chemical\niodine\tI-Chemical\nirrigations\tO\nwere\tO\nassociated\tO\nwith\tO\nerosive\tO\ncystitis\tB-Disease\nand\tO\nsuggested\tO\na\tO\npossible\tO\ncomplication\tO\nwith\tO\nhuman\tO\nusage\tO\n.\tO\n\nPicloxydine\tB-Chemical\nirrigations\tO\nappeared\tO\nto\tO\nhave\tO\na\tO\nlower\tO\nincidence\tO\nof\tO\nerosive\tO\ncystitis\tB-Disease\nbut\tO\nfurther\tO\nstudies\tO\nwould\tO\nhave\tO\nto\tO\nbe\tO\nperformed\tO\nbefore\tO\nit\tO\ncould\tO\nbe\tO\nrecommended\tO\nfor\tO\nuse\tO\nin\tO\nurological\tO\nprocedures\tO\n.\tO\n\nEffects\tO\nof\tO\ntetrandrine\tB-Chemical\nand\tO\nfangchinoline\tB-Chemical\non\tO\nexperimental\tO\nthrombosis\tB-Disease\nin\tO\nmice\tO\nand\tO\nhuman\tO\nplatelet\tB-Disease\naggregation\tI-Disease\n.\tO\n\nTetrandrine\tO\n(\tO\nTET\tB-Chemical\n)\tO\nand\tO\nfangchinoline\tB-Chemical\n(\tO\nFAN\tB-Chemical\n)\tO\nare\tO\ntwo\tO\nnaturally\tO\noccurring\tO\nanalogues\tO\nwith\tO\na\tO\nbisbenzylisoquinoline\tB-Chemical\nstructure\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\nTET\tB-Chemical\nand\tO\nFAN\tB-Chemical\non\tO\nthe\tO\nexperimental\tO\nthrombosis\tB-Disease\ninduced\tO\nby\tO\ncollagen\tO\nplus\tO\nepinephrine\tB-Chemical\n(\tO\nEP\tB-Chemical\n)\tO\nin\tO\nmice\tO\n,\tO\nand\tO\nplatelet\tB-Disease\naggregation\tI-Disease\nand\tO\nblood\tB-Disease\ncoagulation\tI-Disease\nin\tO\nvitro\tO\n.\tO\n\nIn\tO\nthe\tO\nin\tO\nvivo\tO\nstudy\tO\n,\tO\nthe\tO\nadministration\tO\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nof\tO\nTET\tB-Chemical\nand\tO\nFAN\tB-Chemical\nin\tO\nmice\tO\nshowed\tO\nthe\tO\ninhibition\tO\nof\tO\nthrombosis\tB-Disease\nby\tO\n55\tO\n%\tO\nand\tO\n35\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nwhile\tO\nacetylsalicylic\tB-Chemical\nacid\tI-Chemical\n(\tO\nASA\tB-Chemical\n,\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\na\tO\npositive\tO\ncontrol\tO\n,\tO\nshowed\tO\nonly\tO\n30\tO\n%\tO\ninhibition\tO\n.\tO\n\nIn\tO\nthe\tO\nvitro\tO\nhuman\tO\nplatelet\tB-Disease\naggregations\tI-Disease\ninduced\tO\nby\tO\nthe\tO\nagonists\tO\nused\tO\nin\tO\ntests\tO\n,\tO\nTET\tB-Chemical\nand\tO\nFAN\tB-Chemical\nshowed\tO\nthe\tO\ninhibitions\tO\ndose\tO\ndependently\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nneither\tO\nTET\tB-Chemical\nnor\tO\nFAN\tB-Chemical\nshowed\tO\nany\tO\nanticoagulation\tO\nactivities\tO\nin\tO\nthe\tO\nmeasurement\tO\nof\tO\nthe\tO\nactivated\tO\npartial\tO\nthromboplastin\tO\ntime\tO\n(\tO\nAPTT\tO\n)\tO\n,\tO\nprothrombin\tO\ntime\tO\n(\tO\nPT\tO\n)\tO\nand\tO\nthrombin\tO\ntime\tO\n(\tO\nTT\tO\n)\tO\nusing\tO\nhuman\tO\n-\tO\ncitrated\tO\nplasma\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\nantithrombosis\tO\nof\tO\nTET\tB-Chemical\nand\tO\nFAN\tB-Chemical\nin\tO\nmice\tO\nmay\tO\nbe\tO\nmainly\tO\nrelated\tO\nto\tO\nthe\tO\nantiplatelet\tO\naggregation\tO\nactivities\tO\n.\tO\n\nAngioedema\tB-Disease\ndue\tO\nto\tO\nACE\tB-Chemical\ninhibitors\tI-Chemical\n:\tO\ncommon\tO\nand\tO\ninadequately\tO\ndiagnosed\tO\n.\tO\n\nThe\tO\nestimated\tO\nincidence\tO\nof\tO\nangioedema\tB-Disease\nduring\tO\nangiotensin\tB-Chemical\n-\tI-Chemical\nconverting\tI-Chemical\nenzyme\tI-Chemical\n(\tI-Chemical\nACE\tI-Chemical\n)\tI-Chemical\ninhibitor\tI-Chemical\ntreatment\tO\nis\tO\nbetween\tO\n1\tO\nand\tO\n7\tO\nper\tO\nthousand\tO\npatients\tO\n.\tO\n\nCocaine\tB-Chemical\n-\tO\ninduced\tO\nmood\tB-Disease\ndisorder\tI-Disease\n:\tO\nprevalence\tO\nrates\tO\nand\tO\npsychiatric\tB-Disease\nsymptoms\tO\nin\tO\nan\tO\noutpatient\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tO\nsample\tO\n.\tO\n\nThis\tO\npaper\tO\nattempts\tO\nto\tO\nexamine\tO\nand\tO\ncompare\tO\nprevalence\tO\nrates\tO\nand\tO\nsymptom\tO\npatterns\tO\nof\tO\nDSM\tO\nsubstance\tO\n-\tO\ninduced\tO\nand\tO\nother\tO\nmood\tB-Disease\ndisorders\tI-Disease\n.\tO\n\n243\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tO\noutpatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nmood\tB-Disease\ndisorder\tI-Disease\n(\tO\nCIMD\tB-Disease\n)\tO\n,\tO\nother\tO\nmood\tB-Disease\ndisorders\tI-Disease\n,\tO\nor\tO\nno\tO\nmood\tB-Disease\ndisorder\tI-Disease\nwere\tO\ncompared\tO\non\tO\nmeasures\tO\nof\tO\npsychiatric\tB-Disease\nsymptoms\tO\n.\tO\n\nThe\tO\nprevalence\tO\nrate\tO\nfor\tO\nCIMD\tB-Disease\nwas\tO\n12\tO\n%\tO\nat\tO\nbaseline\tO\n.\tO\n\nIntroduction\tO\nof\tO\nthe\tO\nDSM\tO\n-\tO\nIV\tO\ndiagnosis\tO\nof\tO\nCIMD\tB-Disease\ndid\tO\nnot\tO\nsubstantially\tO\naffect\tO\nrates\tO\nof\tO\nthe\tO\nother\tO\ndepressive\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nPatients\tO\nwith\tO\nCIMD\tB-Disease\nhad\tO\nsymptom\tO\nseverity\tO\nlevels\tO\nbetween\tO\nthose\tO\nof\tO\npatients\tO\nwith\tO\nand\tO\nwithout\tO\na\tO\nmood\tO\ndisorder\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nsome\tO\nvalidity\tO\nfor\tO\nthe\tO\nnew\tO\nDSM\tO\n-\tO\nIV\tO\ndiagnosis\tO\nof\tO\nCIMD\tB-Disease\n,\tO\nbut\tO\nalso\tO\nsuggest\tO\nthat\tO\nit\tO\nrequires\tO\nfurther\tO\nspecification\tO\nand\tO\nreplication\tO\n.\tO\n\nEffect\tO\nof\tO\nfucoidan\tB-Chemical\ntreatment\tO\non\tO\ncollagenase\tO\n-\tO\ninduced\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nInflammatory\tO\ncells\tO\nare\tO\npostulated\tO\nto\tO\nmediate\tO\nsome\tO\nof\tO\nthe\tO\nbrain\tB-Disease\ndamage\tI-Disease\nfollowing\tO\nischemic\tB-Disease\nstroke\tI-Disease\n.\tO\n\nIntracerebral\tB-Disease\nhemorrhage\tI-Disease\nis\tO\nassociated\tO\nwith\tO\nmore\tO\ninflammation\tB-Disease\nthan\tO\nischemic\tB-Disease\nstroke\tI-Disease\n.\tO\n\nWe\tO\ntested\tO\nthe\tO\nsulfated\tO\npolysaccharide\tO\nfucoidan\tB-Chemical\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nreduce\tO\ninflammatory\tO\nbrain\tB-Disease\ndamage\tI-Disease\n,\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\ninduced\tO\nby\tO\ninjection\tO\nof\tO\nbacterial\tO\ncollagenase\tO\ninto\tO\nthe\tO\ncaudate\tO\nnucleus\tO\n.\tO\n\nRats\tO\nwere\tO\ntreated\tO\nwith\tO\nseven\tO\nday\tO\nintravenous\tO\ninfusion\tO\nof\tO\nfucoidan\tB-Chemical\n(\tO\n30\tO\nmicrograms\tO\nh\tO\n-\tO\n1\tO\n)\tO\nor\tO\nvehicle\tO\n.\tO\n\nThe\tO\nhematoma\tB-Disease\nwas\tO\nassessed\tO\nin\tO\nvivo\tO\nby\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n.\tO\n\nFucoidan\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\nexhibited\tO\nevidence\tO\nof\tO\nimpaired\tB-Disease\nblood\tI-Disease\nclotting\tI-Disease\nand\tO\nhemodilution\tB-Disease\n,\tO\nhad\tO\nlarger\tO\nhematomas\tB-Disease\n,\tO\nand\tO\ntended\tO\nto\tO\nhave\tO\nless\tO\ninflammation\tB-Disease\nin\tO\nthe\tO\nvicinity\tO\nof\tO\nthe\tO\nhematoma\tO\nafter\tO\nthree\tO\ndays\tO\n.\tO\n\nThey\tO\nshowed\tO\nsignificantly\tO\nmore\tO\nrapid\tO\nimprovement\tO\nof\tO\nmotor\tO\nfunction\tO\nin\tO\nthe\tO\nfirst\tO\nweek\tO\nfollowing\tO\nhemorrhage\tB-Disease\nand\tO\nbetter\tO\nmemory\tO\nretention\tO\nin\tO\nthe\tO\npassive\tO\navoidance\tO\ntest\tO\n.\tO\n\nAcute\tO\nwhite\tB-Disease\nmatter\tI-Disease\nedema\tI-Disease\nand\tO\neventual\tO\nneuronal\tO\nloss\tO\nin\tO\nthe\tO\nstriatum\tO\nadjacent\tO\nto\tO\nthe\tO\nhematoma\tB-Disease\ndid\tO\nnot\tO\ndiffer\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nInvestigation\tO\nof\tO\nmore\tO\nspecific\tO\nanti\tO\n-\tO\ninflammatory\tO\nagents\tO\nand\tO\nhemodiluting\tO\nagents\tO\nare\tO\nwarranted\tO\nin\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n.\tO\n\nAccumulation\tO\nof\tO\natracurium\tB-Chemical\nin\tO\nthe\tO\nintravenous\tO\nline\tO\nled\tO\nto\tO\nrecurarization\tO\nafter\tO\nflushing\tO\nthe\tO\nline\tO\nin\tO\nthe\tO\nrecovery\tO\nroom\tO\n.\tO\n\nA\tO\nrespiratory\tB-Disease\narrest\tI-Disease\nwith\tO\nsevere\tO\ndesaturation\tB-Disease\nand\tO\nbradycardia\tB-Disease\noccurred\tO\n.\tO\n\nCircumstances\tO\nleading\tO\nto\tO\nthis\tO\nevent\tO\nand\tO\nthe\tO\nmechanisms\tO\nenabling\tO\na\tO\nneuromuscular\tB-Disease\nblockade\tI-Disease\nto\tO\noccur\tO\n,\tO\nfollowing\tO\nthe\tO\nadministration\tO\nof\tO\na\tO\nsmall\tO\ndose\tO\nof\tO\nrelaxant\tO\n,\tO\nare\tO\ndiscussed\tO\n.\tO\n\nThe\tO\nhaemodynamic\tO\neffects\tO\nof\tO\npropofol\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\nephedrine\tB-Chemical\nin\tO\nelderly\tO\npatients\tO\n(\tO\nASA\tO\ngroups\tO\n3\tO\nand\tO\n4\tO\n)\tO\n.\tO\n\nThe\tO\nmarked\tO\nvasodilator\tO\nand\tO\nnegative\tO\ninotropic\tO\neffects\tO\nof\tO\npropofol\tB-Chemical\nare\tO\ndisadvantages\tO\nin\tO\nfrail\tO\nelderly\tO\npatients\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nadding\tO\ndifferent\tO\ndoses\tO\nof\tO\nephedrine\tB-Chemical\nto\tO\npropofol\tB-Chemical\nin\tO\norder\tO\nto\tO\nobtund\tO\nthe\tO\nhypotensive\tB-Disease\nresponse\tO\n.\tO\n\nThe\tO\nhaemodynamic\tO\neffects\tO\nof\tO\nadding\tO\n15\tO\n,\tO\n20\tO\nor\tO\n25\tO\nmg\tO\nof\tO\nephedrine\tB-Chemical\nto\tO\n200\tO\nmg\tO\nof\tO\npropofol\tB-Chemical\nwere\tO\ncompared\tO\nto\tO\ncontrol\tO\nin\tO\n40\tO\nASA\tO\n3\tO\n/\tO\n4\tO\npatients\tO\nover\tO\n60\tO\nyears\tO\npresenting\tO\nfor\tO\ngenito\tO\n-\tO\nurinary\tO\nsurgery\tO\n.\tO\n\nThe\tO\naddition\tO\nof\tO\nephedrine\tB-Chemical\nto\tO\npropofol\tB-Chemical\nappears\tO\nto\tO\nbe\tO\nan\tO\neffective\tO\nmethod\tO\nof\tO\nobtunding\tO\nthe\tO\nhypotensive\tB-Disease\nresponse\tO\nto\tO\npropofol\tB-Chemical\nat\tO\nall\tO\ndoses\tO\nused\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nHowever\tO\n,\tO\nmarked\tO\ntachycardia\tB-Disease\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nephedrine\tB-Chemical\nin\tO\ncombination\tO\nwith\tO\npropofol\tB-Chemical\noccurred\tO\nin\tO\nthe\tO\nmajority\tO\nof\tO\npatients\tO\n,\tO\noccasionally\tO\nreaching\tO\nhigh\tO\nlevels\tO\nin\tO\nindividual\tO\npatients\tO\n.\tO\n\nDue\tO\nto\tO\nthe\tO\nrisk\tO\nof\tO\nthis\tO\ntachycardia\tB-Disease\ninducing\tO\nmyocardial\tB-Disease\nischemia\tI-Disease\n,\tO\nwe\tO\nwould\tO\nnot\tO\nrecommend\tO\nthe\tO\nuse\tO\nin\tO\nelderly\tO\npatients\tO\nof\tO\nany\tO\nof\tO\nthe\tO\nephedrine\tB-Chemical\n/\tO\npropofol\tB-Chemical\n/\tO\nmixtures\tO\nstudied\tO\n.\tO\n\nGemcitabine\tB-Chemical\nplus\tO\nvinorelbine\tO\nin\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\npatients\tO\nage\tO\n70\tO\nyears\tO\nor\tO\nolder\tO\nor\tO\npatients\tO\nwho\tO\ncannot\tO\nreceive\tO\ncisplatin\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nAlthough\tO\nthe\tO\nprevalence\tO\nof\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\n(\tO\nNSCLC\tB-Disease\n)\tO\nis\tO\nhigh\tO\namong\tO\nelderly\tO\npatients\tO\n,\tO\nfew\tO\ndata\tO\nare\tO\navailable\tO\nregarding\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\nchemotherapy\tO\nin\tO\nthis\tO\ngroup\tO\nof\tO\npatients\tO\n.\tO\n\nRecent\tO\nreports\tO\nindicate\tO\nthat\tO\nsingle\tO\nagent\tO\ntherapy\tO\nwith\tO\nvinorelbine\tB-Chemical\n(\tO\nVNB\tO\n)\tO\nor\tO\ngemcitabine\tB-Chemical\n(\tO\nGEM\tB-Chemical\n)\tO\nmay\tO\nobtain\tO\na\tO\nresponse\tO\nrate\tO\nof\tO\n20\tO\n-\tO\n30\tO\n%\tO\nin\tO\nelderly\tO\npatients\tO\n,\tO\nwith\tO\nacceptable\tO\ntoxicity\tB-Disease\nand\tO\nimprovement\tO\nin\tO\nsymptoms\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\nthe\tO\ncombination\tO\nof\tO\nGEM\tB-Chemical\nand\tO\nVNB\tB-Chemical\nin\tO\nelderly\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tB-Disease\nor\tO\nthose\tO\nwith\tO\nsome\tO\ncontraindication\tO\nto\tO\nreceiving\tO\ncisplatin\tB-Chemical\nwere\tO\nassessed\tO\n.\tO\n\nMETHODS\tO\n:\tO\nForty\tO\n-\tO\nnine\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tB-Disease\nwere\tO\nincluded\tO\n,\tO\n38\tO\nof\tO\nwhom\tO\nwere\tO\nage\tO\n>\tO\n/\tO\n=\tO\n70\tO\nyears\tO\nand\tO\n11\tO\nwere\tO\nage\tO\n<\tO\n70\tO\nyears\tO\nbut\tO\nwho\tO\nhad\tO\nsome\tO\ncontraindication\tO\nto\tO\nreceiving\tO\ncisplatin\tB-Chemical\n.\tO\n\nTreatment\tO\nwas\tO\ncomprised\tO\nof\tO\nVNB\tB-Chemical\n,\tO\n25\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n,\tO\nplus\tO\nGEM\tB-Chemical\n,\tO\n1000\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n,\tO\nboth\tO\non\tO\nDays\tO\n1\tO\n,\tO\n8\tO\n,\tO\nand\tO\n15\tO\nevery\tO\n28\tO\ndays\tO\n.\tO\n\nToxicity\tB-Disease\nwas\tO\nmild\tO\n.\tO\n\nSix\tO\npatients\tO\n(\tO\n12\tO\n%\tO\n)\tO\nhad\tO\nWorld\tO\nHealth\tO\nOrganization\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tO\n,\tO\n2\tO\npatients\tO\n(\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nthrombocytopenia\tB-Disease\n,\tO\nand\tO\n2\tO\npatients\tO\n(\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nGrade\tO\n3\tO\nneurotoxicity\tB-Disease\n.\tO\n\nThree\tO\npatients\tO\nwith\tO\nsevere\tO\nneutropenia\tB-Disease\n(\tO\n6\tO\n%\tO\n)\tO\ndied\tO\nof\tO\nsepsis\tB-Disease\n.\tO\n\nThe\tO\nmedian\tO\nage\tO\nof\tO\nthose\tO\npatients\tO\ndeveloping\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tB-Disease\nwas\tO\nsignificantly\tO\nhigher\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\nremaining\tO\npatients\tO\n(\tO\n75\tO\nyears\tO\nvs\tO\n.\tO\n72\tO\nyears\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n047\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tO\nof\tO\nGEM\tB-Chemical\nand\tO\nVNB\tB-Chemical\nis\tO\nmoderately\tO\nactive\tO\nand\tO\nwell\tO\ntolerated\tO\nexcept\tO\nin\tO\npatients\tO\nage\tO\n>\tO\n/\tO\n=\tO\n75\tO\nyears\tO\n.\tO\n\nThis\tO\nage\tO\ngroup\tO\nhad\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nmyelosuppression\tB-Disease\n.\tO\n\nNew\tO\nchemotherapy\tO\ncombinations\tO\nwith\tO\nhigher\tO\nactivity\tO\nand\tO\nlower\tO\ntoxicity\tB-Disease\nare\tO\nneeded\tO\nfor\tO\nelderly\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tB-Disease\n.\tO\n\nA\tO\nselective\tO\ndopamine\tB-Chemical\nD4\tO\nreceptor\tO\nantagonist\tO\n,\tO\nNRA0160\tB-Chemical\n:\tO\na\tO\npreclinical\tO\nneuropharmacological\tO\nprofile\tO\n.\tO\n\nNRA0160\tO\n,\tO\n5\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nfluorobenzylidene\tI-Chemical\n)\tI-Chemical\npiperidin\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nfluorophenyl\tI-Chemical\n)\tI-Chemical\nthiazole\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ncarboxamide\tI-Chemical\n,\tO\nhas\tO\na\tO\nhigh\tO\naffinity\tO\nfor\tO\nhuman\tO\ncloned\tO\ndopamine\tO\nD4\tO\n.\tO\n2\tO\n,\tO\nD4\tO\n.\tO\n4\tO\nand\tO\nD4\tO\n.\tO\n7\tO\nreceptors\tO\n,\tO\nwith\tO\nKi\tO\nvalues\tO\nof\tO\n0\tO\n.\tO\n5\tO\n,\tO\n0\tO\n.\tO\n9\tO\nand\tO\n2\tO\n.\tO\n7\tO\nnM\tO\n,\tO\nrespectively\tO\n.\tO\n\nNRA0160\tB-Chemical\nis\tO\nover\tO\n20\tO\n,\tO\n000fold\tO\nmore\tO\npotent\tO\nat\tO\nthe\tO\ndopamine\tB-Chemical\nD4\tO\n.\tO\n2\tO\nreceptor\tO\ncompared\tO\nwith\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tB-Chemical\nD2L\tO\nreceptor\tO\n.\tO\n\nNRA0160\tB-Chemical\nhas\tO\nnegligible\tO\naffinity\tO\nfor\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tB-Chemical\nD3\tO\nreceptor\tO\n(\tO\nKi\tO\n=\tO\n39\tO\nnM\tO\n)\tO\n,\tO\nrat\tO\nserotonin\tB-Chemical\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n)\tO\n2A\tO\nreceptors\tO\n(\tO\nKi\tO\n=\tO\n180\tO\nnM\tO\n)\tO\nand\tO\nrat\tO\nalpha1\tO\nadrenoceptor\tO\n(\tO\nKi\tO\n=\tO\n237\tO\nnM\tO\n)\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nantagonized\tO\nlocomotor\tO\nhyperactivity\tB-Disease\ninduced\tO\nby\tO\nmethamphetamine\tB-Chemical\n(\tO\nMAP\tB-Chemical\n)\tO\nin\tO\nmice\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nantagonized\tO\nMAP\tB-Chemical\n-\tO\ninduced\tO\nstereotyped\tO\nbehavior\tO\nin\tO\nmice\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tO\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninhibition\tO\n,\tO\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nsignificantly\tO\ninduced\tO\ncatalepsy\tB-Disease\nin\tO\nrats\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tO\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninduction\tO\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nsignificantly\tO\nreversed\tO\nthe\tO\ndisruption\tO\nof\tO\nprepulse\tO\ninhibition\tO\n(\tO\nPPI\tO\n)\tO\nin\tO\nrats\tO\nproduced\tO\nby\tO\napomorphine\tB-Chemical\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tB-Chemical\nsignificantly\tO\nshortened\tO\nthe\tO\nphencyclidine\tB-Chemical\n(\tO\nPCP\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nprolonged\tO\nswimming\tO\nlatency\tO\nin\tO\nrats\tO\nin\tO\na\tO\nwater\tO\nmaze\tO\ntask\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nNRA0160\tB-Chemical\nmay\tO\nhave\tO\nunique\tO\nantipsychotic\tO\nactivities\tO\nwithout\tO\nthe\tO\nliability\tO\nof\tO\nmotor\tO\nside\tO\neffects\tO\ntypical\tO\nof\tO\nclassical\tO\nantipsychotics\tO\n.\tO\n\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\nartery\tB-Disease\ncalcification\tI-Disease\nis\tO\naccelerated\tO\nby\tO\ngrowth\tO\nand\tO\nvitamin\tB-Chemical\nD\tI-Chemical\n.\tO\n\nThe\tO\npresent\tO\nstudies\tO\ndemonstrate\tO\nthat\tO\ngrowth\tO\nand\tO\nvitamin\tB-Chemical\nD\tI-Chemical\ntreatment\tO\nenhance\tO\nthe\tO\nextent\tO\nof\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nrats\tO\ngiven\tO\nsufficient\tO\ndoses\tO\nof\tO\nWarfarin\tB-Chemical\nto\tO\ninhibit\tO\ngamma\tO\n-\tO\ncarboxylation\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\n,\tO\na\tO\ncalcification\tB-Disease\ninhibitor\tO\nknown\tO\nto\tO\nbe\tO\nexpressed\tO\nby\tO\nsmooth\tO\nmuscle\tO\ncells\tO\nand\tO\nmacrophages\tO\nin\tO\nthe\tO\nartery\tO\nwall\tO\n.\tO\n\nThe\tO\nfirst\tO\nseries\tO\nof\tO\nexperiments\tO\nexamined\tO\nthe\tO\ninfluence\tO\nof\tO\nage\tO\nand\tO\ngrowth\tO\nstatus\tO\non\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nWarfarin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nTreatment\tO\nfor\tO\n2\tO\nweeks\tO\nwith\tO\nWarfarin\tB-Chemical\ncaused\tO\nmassive\tO\nfocal\tO\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\nin\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nless\tO\nextensive\tO\nfocal\tO\ncalcification\tB-Disease\nin\tO\n42\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nno\tO\nartery\tB-Disease\ncalcification\tI-Disease\ncould\tO\nbe\tO\ndetected\tO\nin\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nadult\tO\nrats\tO\neven\tO\nafter\tO\n4\tO\nweeks\tO\nof\tO\nWarfarin\tB-Chemical\ntreatment\tO\n.\tO\n\nTo\tO\ndirectly\tO\nexamine\tO\nthe\tO\nimportance\tO\nof\tO\ngrowth\tO\nto\tO\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nanimals\tO\nof\tO\nthe\tO\nsame\tO\nage\tO\n,\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\nwere\tO\nfed\tO\nfor\tO\n2\tO\nweeks\tO\neither\tO\nan\tO\nad\tO\nlibitum\tO\ndiet\tO\nor\tO\na\tO\n6\tO\n-\tO\ng\tO\n/\tO\nd\tO\nrestricted\tO\ndiet\tO\nthat\tO\nmaintains\tO\nweight\tO\nbut\tO\nprevents\tO\ngrowth\tO\n.\tO\n\nConcurrent\tO\ntreatment\tO\nof\tO\nboth\tO\ndietary\tO\ngroups\tO\nwith\tO\nWarfarin\tB-Chemical\nproduced\tO\nmassive\tO\nfocal\tO\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\nin\tO\nthe\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\nbut\tO\nno\tO\ndetectable\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\ngroup\tO\n.\tO\n\nAlthough\tO\nthe\tO\nexplanation\tO\nfor\tO\nthe\tO\nassociation\tO\nbetween\tO\nartery\tB-Disease\ncalcification\tI-Disease\nand\tO\ngrowth\tO\nstatus\tO\ncannot\tO\nbe\tO\ndetermined\tO\nfrom\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nrelationship\tO\nbetween\tO\nhigher\tO\nserum\tO\nphosphate\tB-Chemical\nand\tO\nsusceptibility\tO\nto\tO\nartery\tB-Disease\ncalcification\tI-Disease\n,\tO\nwith\tO\n30\tO\n%\tO\nhigher\tO\nlevels\tO\nof\tO\nserum\tO\nphosphate\tB-Chemical\nin\tO\nyoung\tO\n,\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\ncompared\tO\nwith\tO\neither\tO\nof\tO\nthe\tO\ngroups\tO\nthat\tO\nwas\tO\nresistant\tO\nto\tO\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\nartery\tB-Disease\ncalcification\tI-Disease\n,\tO\nie\tO\n,\tO\nthe\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\nyoung\tO\nrats\tO\n.\tO\n\nThis\tO\nobservation\tO\nsuggests\tO\nthat\tO\nincreased\tO\nsusceptibility\tO\nto\tO\nWarfarin\tB-Chemical\n-\tO\ninduced\tO\nartery\tB-Disease\ncalcification\tI-Disease\ncould\tO\nbe\tO\nrelated\tO\nto\tO\nhigher\tO\nserum\tO\nphosphate\tB-Chemical\nlevels\tO\n.\tO\n\nThe\tO\nsecond\tO\nset\tO\nof\tO\nexperiments\tO\nexamined\tO\nthe\tO\npossible\tO\nsynergy\tO\nbetween\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nand\tO\nWarfarin\tB-Chemical\nin\tO\nartery\tB-Disease\ncalcification\tI-Disease\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nare\tO\nknown\tO\nto\tO\ncause\tO\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\nin\tO\nas\tO\nlittle\tO\nas\tO\n3\tO\nto\tO\n4\tO\ndays\tO\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\nthe\tO\nvitamin\tB-Chemical\nK\tI-Chemical\nantagonist\tO\nWarfarin\tB-Chemical\nare\tO\nalso\tO\nknown\tO\nto\tO\ncause\tO\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\n,\tO\nbut\tO\nat\tO\ntreatment\tO\ntimes\tO\nof\tO\n2\tO\nweeks\tO\nor\tO\nlonger\tO\nyet\tO\nnot\tO\nat\tO\n1\tO\nweek\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\nsynergy\tO\nbetween\tO\nthese\tO\n2\tO\ntreatments\tO\nand\tO\nfound\tO\nthat\tO\nconcurrent\tO\nWarfarin\tB-Chemical\nadministration\tO\ndramatically\tO\nincreased\tO\nthe\tO\nextent\tO\nof\tO\ncalcification\tB-Disease\nin\tO\nthe\tO\nmedia\tO\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\n-\tO\ntreated\tO\nrats\tO\nat\tO\n3\tO\nand\tO\n4\tO\ndays\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nclose\tO\nparallel\tO\nbetween\tO\nthe\tO\neffect\tO\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\ndose\tO\non\tO\nartery\tB-Disease\ncalcification\tI-Disease\nand\tO\nthe\tO\neffect\tO\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\ndose\tO\non\tO\nthe\tO\nelevation\tO\nof\tO\nserum\tO\ncalcium\tB-Chemical\n,\tO\nwhich\tO\nsuggests\tO\nthat\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nmay\tO\ninduce\tO\nartery\tB-Disease\ncalcification\tI-Disease\nthrough\tO\nits\tO\neffect\tO\non\tO\nserum\tO\ncalcium\tB-Chemical\n.\tO\n\nBecause\tO\nWarfarin\tB-Chemical\ntreatment\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nelevation\tO\nin\tO\nserum\tO\ncalcium\tB-Chemical\nproduced\tO\nby\tO\nvitamin\tB-Chemical\nD\tI-Chemical\n,\tO\nthe\tO\nsynergy\tO\nbetween\tO\nWarfarin\tB-Chemical\nand\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nis\tO\nprobably\tO\nbest\tO\nexplained\tO\nby\tO\nthe\tO\nhypothesis\tO\nthat\tO\nWarfarin\tB-Chemical\ninhibits\tO\nthe\tO\nactivity\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nas\tO\na\tO\ncalcification\tB-Disease\ninhibitor\tO\n.\tO\n\nHigh\tO\nlevels\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\nfound\tO\nat\tO\nsites\tO\nof\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nrats\tO\ntreated\tO\nwith\tO\nvitamin\tB-Chemical\nD\tI-Chemical\nplus\tO\nWarfarin\tB-Chemical\n,\tO\nand\tO\nchemical\tO\nanalysis\tO\nshowed\tO\nthat\tO\nthe\tO\nprotein\tO\nthat\tO\naccumulated\tO\nwas\tO\nindeed\tO\nnot\tO\ngamma\tB-Chemical\n-\tI-Chemical\ncarboxylated\tI-Chemical\n.\tO\n\nThese\tO\nobservations\tO\nindicate\tO\nthat\tO\nalthough\tO\nthe\tO\ngamma\tB-Chemical\n-\tI-Chemical\ncarboxyglutamate\tI-Chemical\nresidues\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\napparently\tO\nrequired\tO\nfor\tO\nits\tO\nfunction\tO\nas\tO\na\tO\ncalcification\tB-Disease\ninhibitor\tO\n,\tO\nthey\tO\nare\tO\nnot\tO\nrequired\tO\nfor\tO\nits\tO\naccumulation\tO\nat\tO\ncalcification\tB-Disease\nsites\tO\n.\tO\n\nApomorphine\tB-Chemical\n,\tO\na\tO\nnonselective\tO\ndopamine\tB-Chemical\nagonist\tI-Chemical\n,\tO\nwas\tO\nselected\tO\ndue\tO\nto\tO\nits\tO\nbiphasic\tO\nbehavioral\tO\neffects\tO\n,\tO\nits\tO\nability\tO\nto\tO\ninduce\tO\nhypothermia\tB-Disease\n,\tO\nand\tO\nto\tO\nproduce\tO\ndistinct\tO\nchanges\tO\nto\tO\ndopamine\tB-Chemical\nturnover\tO\nin\tO\nthe\tO\nrodent\tO\nbrain\tO\n.\tO\n\nFrom\tO\nsuch\tO\nexperiments\tO\nthere\tO\nis\tO\nevidence\tO\nthat\tO\ncharacterization\tO\nand\tO\ndetection\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nactivity\tO\nin\tO\nrodents\tO\ncritically\tO\ndepends\tO\nupon\tO\nthe\tO\ntest\tO\nconditions\tO\nemployed\tO\n.\tO\n\nIn\tO\nrats\tO\n,\tO\ndetection\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nwas\tO\nfacilitated\tO\nby\tO\na\tO\nperiod\tO\nof\tO\nacclimatization\tO\nto\tO\nthe\tO\ntest\tO\nconditions\tO\n.\tO\n\nMoreover\tO\n,\tO\ntest\tO\nconditions\tO\ncan\tO\nimpact\tO\nupon\tO\nother\tO\nphysiological\tO\nresponses\tO\nto\tO\napomorphine\tB-Chemical\nsuch\tO\nas\tO\ndrug\tO\n-\tO\ninduced\tO\nhypothermia\tB-Disease\n.\tO\n\nIn\tO\nmice\tO\n,\tO\napomorphine\tB-Chemical\nproduced\tO\nqualitatively\tO\ndifferent\tO\nresponses\tO\nunder\tO\nnovel\tO\nconditions\tO\nwhen\tO\ncompared\tO\nto\tO\nthose\tO\nbehaviors\tO\nelicited\tO\nin\tO\nthe\tO\nhome\tO\ntest\tO\ncage\tO\n.\tO\n\nBy\tO\ncontrast\tO\n,\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nlocomotion\tO\nwas\tO\nmore\tO\nprominent\tO\nin\tO\nthe\tO\nnovel\tO\nexploratory\tO\nbox\tO\n.\tO\n\nDopamine\tB-Chemical\nturnover\tO\nratios\tO\n(\tO\nDOPAC\tB-Chemical\n:\tO\nDA\tO\nand\tO\nHVA\tB-Chemical\n:\tO\nDA\tB-Chemical\n)\tO\nwere\tO\nfound\tO\nto\tO\nbe\tO\nlower\tO\nin\tO\nthose\tO\nanimals\tO\nexposed\tO\nto\tO\nthe\tO\nexploratory\tO\nbox\tO\nwhen\tO\ncompared\tO\nto\tO\ntheir\tO\nhome\tO\ncage\tO\ncounterparts\tO\n.\tO\n\nHowever\tO\n,\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\nreductions\tO\nin\tO\nstriatal\tO\ndopamine\tB-Chemical\nturnover\tO\nwere\tO\ndetected\tO\nin\tO\nboth\tO\nnovel\tO\nand\tO\nhome\tO\ncage\tO\nenvironments\tO\n.\tO\n\nHemolysis\tB-Disease\nof\tO\nhuman\tO\nerythrocytes\tO\ninduced\tO\nby\tO\ntamoxifen\tB-Chemical\nis\tO\nrelated\tO\nto\tO\ndisruption\tO\nof\tO\nmembrane\tO\nstructure\tO\n.\tO\n\nTamoxifen\tB-Chemical\n(\tO\nTAM\tB-Chemical\n)\tO\n,\tO\nthe\tO\nantiestrogenic\tO\ndrug\tO\nmost\tO\nwidely\tO\nprescribed\tO\nin\tO\nthe\tO\nchemotherapy\tO\nof\tO\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\ninduces\tO\nchanges\tO\nin\tO\nnormal\tO\ndiscoid\tO\nshape\tO\nof\tO\nerythrocytes\tO\nand\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\neffects\tO\nof\tO\nTAM\tB-Chemical\non\tO\nisolated\tO\nhuman\tO\nerythrocytes\tO\n,\tO\nattempting\tO\nto\tO\nidentify\tO\nthe\tO\nunderlying\tO\nmechanisms\tO\non\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\nand\tO\nthe\tO\ninvolvement\tO\nof\tO\nbiomembranes\tO\nin\tO\nits\tO\ncytostatic\tO\naction\tO\nmechanisms\tO\n.\tO\n\nTAM\tB-Chemical\ninduces\tO\nhemolysis\tB-Disease\nof\tO\nerythrocytes\tO\nas\tO\na\tO\nfunction\tO\nof\tO\nconcentration\tO\n.\tO\n\nThe\tO\nextension\tO\nof\tO\nhemolysis\tB-Disease\nis\tO\nvariable\tO\nwith\tO\nerythrocyte\tO\nsamples\tO\n,\tO\nbut\tO\n12\tO\n.\tO\n5\tO\nmicroM\tO\nTAM\tB-Chemical\ninduces\tO\ntotal\tO\nhemolysis\tB-Disease\nof\tO\nall\tO\ntested\tO\nsuspensions\tO\n.\tO\n\nDespite\tO\ninducing\tO\nextensive\tO\nerythrocyte\tO\nlysis\tO\n,\tO\nTAM\tB-Chemical\ndoes\tO\nnot\tO\nshift\tO\nthe\tO\nosmotic\tO\nfragility\tO\ncurves\tO\nof\tO\nerythrocytes\tO\n.\tO\n\nThe\tO\nhemolytic\tB-Disease\neffect\tO\nof\tO\nTAM\tB-Chemical\nis\tO\nprevented\tO\nby\tO\nlow\tO\nconcentrations\tO\nof\tO\nalpha\tB-Chemical\n-\tI-Chemical\ntocopherol\tI-Chemical\n(\tO\nalpha\tB-Chemical\n-\tI-Chemical\nT\tI-Chemical\n)\tO\nand\tO\nalpha\tB-Chemical\n-\tI-Chemical\ntocopherol\tI-Chemical\nacetate\tI-Chemical\n(\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTAc\tI-Chemical\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tB-Chemical\n)\tO\nindicating\tO\nthat\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\nhemolysis\tB-Disease\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tO\nmembrane\tO\ndamage\tO\n.\tO\n\nThis\tO\nwas\tO\nfurther\tO\nevidenced\tO\nby\tO\nabsence\tO\nof\tO\noxygen\tB-Chemical\nconsumption\tO\nand\tO\nhemoglobin\tO\noxidation\tO\nboth\tO\ndetermined\tO\nin\tO\nparallel\tO\nwith\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\nhemolysis\tB-Disease\n.\tO\n\nFurthermore\tO\n,\tO\nit\tO\nwas\tO\nobserved\tO\nthat\tO\nTAM\tB-Chemical\ninhibits\tO\nthe\tO\nperoxidation\tO\nof\tO\nhuman\tO\nerythrocytes\tO\ninduced\tO\nby\tO\nAAPH\tB-Chemical\n,\tO\nthus\tO\nruling\tO\nout\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\ncell\tO\noxidative\tO\nstress\tO\n.\tO\n\nHemolysis\tB-Disease\ncaused\tO\nby\tO\nTAM\tB-Chemical\nwas\tO\nnot\tO\npreceded\tO\nby\tO\nthe\tO\nleakage\tO\nof\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\nfrom\tO\nthe\tO\ncells\tO\n,\tO\nalso\tO\nexcluding\tO\na\tO\ncolloid\tO\n-\tO\nosmotic\tO\ntype\tO\nmechanism\tO\nof\tO\nhemolysis\tB-Disease\n,\tO\naccording\tO\nto\tO\nthe\tO\neffects\tO\non\tO\nosmotic\tO\nfragility\tO\ncurves\tO\n.\tO\n\nHowever\tO\n,\tO\nTAM\tB-Chemical\ninduces\tO\nrelease\tO\nof\tO\nperipheral\tO\nproteins\tO\nof\tO\nmembrane\tO\n-\tO\ncytoskeleton\tO\nand\tO\ncytosol\tO\nproteins\tO\nessentially\tO\nbound\tO\nto\tO\nband\tO\n3\tO\n.\tO\n\nEither\tO\nalpha\tB-Chemical\n-\tI-Chemical\nT\tI-Chemical\nor\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTAc\tI-Chemical\nincreases\tO\nmembrane\tO\npacking\tO\nand\tO\nprevents\tO\nTAM\tB-Chemical\npartition\tO\ninto\tO\nmodel\tO\nmembranes\tO\n.\tO\n\nThese\tO\neffects\tO\nsuggest\tO\nthat\tO\nthe\tO\nprotection\tO\nfrom\tO\nhemolysis\tB-Disease\nby\tO\ntocopherols\tB-Chemical\nis\tO\nrelated\tO\nto\tO\na\tO\ndecreased\tO\nTAM\tB-Chemical\nincorporation\tO\nin\tO\ncondensed\tO\nmembranes\tO\nand\tO\nthe\tO\nstructural\tO\ndamage\tO\nof\tO\nthe\tO\nerythrocyte\tO\nmembrane\tO\nis\tO\nconsequently\tO\navoided\tO\n.\tO\n\nTherefore\tO\n,\tO\nTAM\tB-Chemical\n-\tO\ninduced\tO\nhemolysis\tB-Disease\nresults\tO\nfrom\tO\na\tO\nstructural\tO\nperturbation\tO\nof\tO\nred\tO\ncell\tO\nmembrane\tO\n,\tO\nleading\tO\nto\tO\nchanges\tO\nin\tO\nthe\tO\nframework\tO\nof\tO\nthe\tO\nerythrocyte\tO\nmembrane\tO\nand\tO\nits\tO\ncytoskeleton\tO\ncaused\tO\nby\tO\nits\tO\nhigh\tO\npartition\tO\nin\tO\nthe\tO\nmembrane\tO\n.\tO\n\nThese\tO\ndefects\tO\nexplain\tO\nthe\tO\nabnormal\tO\nerythrocyte\tO\nshape\tO\nand\tO\ndecreased\tO\nmechanical\tO\nstability\tO\npromoted\tO\nby\tO\nTAM\tB-Chemical\n,\tO\nresulting\tO\nin\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nAdditionally\tO\n,\tO\nsince\tO\nmembrane\tO\nleakage\tO\nis\tO\na\tO\nfinal\tO\nstage\tO\nof\tO\ncytotoxicity\tO\n,\tO\nthe\tO\ndisruption\tO\nof\tO\nthe\tO\nstructural\tO\ncharacteristics\tO\nof\tO\nbiomembranes\tO\nby\tO\nTAM\tB-Chemical\nmay\tO\ncontribute\tO\nto\tO\nthe\tO\nmultiple\tO\nmechanisms\tO\nof\tO\nits\tO\nanticancer\tO\naction\tO\n.\tO\n\nChanges\tO\nof\tO\nsodium\tB-Chemical\nand\tO\nATP\tB-Chemical\naffinities\tO\nof\tO\nthe\tO\ncardiac\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nduring\tO\nand\tO\nafter\tO\nnitric\tB-Chemical\noxide\tI-Chemical\ndeficient\tO\nhypertension\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\ncardiovascular\tO\nsystem\tO\n,\tO\nNO\tB-Chemical\nis\tO\ninvolved\tO\nin\tO\nthe\tO\nregulation\tO\nof\tO\na\tO\nvariety\tO\nof\tO\nfunctions\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tB-Chemical\nsynthesis\tO\ninduces\tO\nsustained\tO\nhypertension\tB-Disease\n.\tO\n\nIn\tO\nseveral\tO\nmodels\tO\nof\tO\nhypertension\tB-Disease\n,\tO\nelevation\tO\nof\tO\nintracellular\tO\nsodium\tB-Chemical\nlevel\tO\nwas\tO\ndocumented\tO\nin\tO\ncardiac\tO\ntissue\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tO\nof\tO\nNa\tB-Chemical\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tO\nof\tO\ncardiac\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tB-Chemical\n-\tO\ndeficient\tO\nhypertension\tB-Disease\ninduced\tO\nin\tO\nrats\tO\nby\tO\nNO\tB-Chemical\n-\tO\nsynthase\tO\ninhibition\tO\nwith\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nN\tB-Chemical\n(\tI-Chemical\nG\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nnitro\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nmethyl\tI-Chemical\nester\tI-Chemical\n(\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nAfter\tO\n4\tO\n-\tO\nweek\tO\nadministration\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n,\tO\nthe\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\nSBP\tO\n)\tO\nincreased\tO\nby\tO\n36\tO\n%\tO\n.\tO\n\nWhen\tO\nactivating\tO\nthe\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nwith\tO\nits\tO\nsubstrate\tO\nATP\tB-Chemical\n,\tO\nno\tO\nchanges\tO\nin\tO\nKm\tO\nand\tO\nVmax\tO\nvalues\tO\nwere\tO\nobserved\tO\nin\tO\nNO\tB-Chemical\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nDuring\tO\nactivation\tO\nwith\tO\nNa\tB-Chemical\n+\tO\n,\tO\nthe\tO\nVmax\tO\nremained\tO\nunchanged\tO\n,\tO\nhowever\tO\nthe\tO\nK\tB-Chemical\n(\tO\nNa\tB-Chemical\n)\tO\nincreased\tO\nby\tO\n50\tO\n%\tO\n,\tO\nindicating\tO\na\tO\nprofound\tO\ndecrease\tO\nin\tO\nthe\tO\naffinity\tO\nof\tO\nthe\tO\nNa\tB-Chemical\n+\tO\n-\tO\nbinding\tO\nsite\tO\nin\tO\nNO\tB-Chemical\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nfrom\tO\nhypertension\tB-Disease\n,\tO\nthe\tO\nactivity\tO\nof\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nincreased\tO\n,\tO\ndue\tO\nto\tO\nhigher\tO\naffinity\tO\nof\tO\nthe\tO\nATP\tB-Chemical\n-\tO\nbinding\tO\nsite\tO\n,\tO\nas\tO\nrevealed\tO\nfrom\tO\nthe\tO\nlowered\tO\nKm\tO\nvalue\tO\nfor\tO\nATP\tB-Chemical\n.\tO\n\nThe\tO\nK\tB-Chemical\n(\tO\nNa\tO\n)\tO\nvalue\tO\nfor\tO\nNa\tB-Chemical\n+\tO\nreturned\tO\nto\tO\ncontrol\tO\nvalue\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tB-Chemical\n-\tO\nsynthase\tO\ninduced\tO\na\tO\nreversible\tO\nhypertension\tB-Disease\naccompanied\tO\nby\tO\ndepressed\tB-Disease\nNa\tB-Chemical\n+\tO\n-\tO\nextrusion\tO\nfrom\tO\ncardiac\tO\ncells\tO\nas\tO\na\tO\nconsequence\tO\nof\tO\ndeteriorated\tO\nNa\tB-Chemical\n+\tO\n-\tO\nbinding\tO\nproperties\tO\nof\tO\nthe\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nof\tO\nblood\tO\npressure\tO\nto\tO\ncontrol\tO\nvalues\tO\n,\tO\nthe\tO\nextrusion\tO\nof\tO\nNa\tB-Chemical\n+\tO\nfrom\tO\ncardiac\tO\ncells\tO\nwas\tO\nnormalized\tO\n,\tO\nas\tO\nrevealed\tO\nby\tO\nrestoration\tO\nof\tO\nthe\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nactivity\tO\n.\tO\n\nEffects\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\npretreatment\tO\nwith\tO\nisoproterenol\tB-Chemical\non\tO\nbromocriptine\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nshown\tO\nthat\tO\nbromocriptine\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\n,\tO\nwhich\tO\npersisted\tO\nafter\tO\nadrenalectomy\tO\n,\tO\nis\tO\n(\tO\ni\tO\n)\tO\nmediated\tO\nby\tO\ncentral\tO\ndopamine\tB-Chemical\nD2\tO\nreceptor\tO\nactivation\tO\nand\tO\n(\tO\nii\tO\n)\tO\nreduced\tO\nby\tO\n5\tO\n-\tO\nday\tO\nisoproterenol\tB-Chemical\npretreatment\tO\n,\tO\nsupporting\tO\ntherefore\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthis\tO\neffect\tO\nis\tO\ndependent\tO\non\tO\nsympathetic\tO\noutflow\tO\nto\tO\nthe\tO\nheart\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nconducted\tO\nto\tO\nexamine\tO\nwhether\tO\nprolonged\tO\npretreatment\tO\nwith\tO\nisoproterenol\tB-Chemical\ncould\tO\nabolish\tO\nbromocriptine\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nIsoproterenol\tB-Chemical\npretreatment\tO\nfor\tO\n15\tO\ndays\tO\ncaused\tO\ncardiac\tB-Disease\nhypertrophy\tI-Disease\nwithout\tO\naffecting\tO\nbaseline\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\n.\tO\n\nIn\tO\ncontrol\tO\nrats\tO\n,\tO\nintravenous\tO\nbromocriptine\tB-Chemical\n(\tO\n150\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\ninduced\tO\nsignificant\tO\nhypotension\tB-Disease\nand\tO\ntachycardia\tB-Disease\n.\tO\n\nBromocriptine\tB-Chemical\n-\tO\ninduced\tO\nhypotension\tB-Disease\nwas\tO\nunaffected\tO\nby\tO\nisoproterenol\tB-Chemical\npretreatment\tO\n,\tO\nwhile\tO\ntachycardia\tB-Disease\nwas\tO\nreversed\tO\nto\tO\nsignificant\tO\nbradycardia\tB-Disease\n,\tO\nan\tO\neffect\tO\nthat\tO\nwas\tO\npartly\tO\nreduced\tO\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\ndomperidone\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nNeither\tO\ncardiac\tO\nvagal\tO\nnor\tO\nsympathetic\tO\ntone\tO\nwas\tO\naltered\tO\nby\tO\nisoproterenol\tB-Chemical\npretreatment\tO\n.\tO\n\nIn\tO\nisolated\tO\nperfused\tO\nheart\tO\npreparations\tO\nfrom\tO\nisoproterenol\tB-Chemical\n-\tO\npretreated\tO\nrats\tO\n,\tO\nthe\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmaximal\tO\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nsignificantly\tO\nreduced\tO\n,\tO\ncompared\tO\nwith\tO\nsaline\tO\n-\tO\npretreated\tO\nrats\tO\n(\tO\nthe\tO\nEC50\tO\nof\tO\nthe\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nenhanced\tO\napproximately\tO\n22\tO\n-\tO\nfold\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tO\nshow\tO\nthat\tO\n15\tO\n-\tO\nday\tO\nisoproterenol\tB-Chemical\npretreatment\tO\nnot\tO\nonly\tO\nabolished\tO\nbut\tO\nreversed\tO\nbromocriptine\tB-Chemical\n-\tO\ninduced\tO\ntachycardia\tB-Disease\nto\tO\nbradycardia\tB-Disease\n,\tO\nan\tO\neffect\tO\nthat\tO\nis\tO\nmainly\tO\nrelated\tO\nto\tO\nfurther\tO\ncardiac\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\ndesensitization\tO\nrather\tO\nthan\tO\nto\tO\nimpairment\tO\nof\tO\nautonomic\tO\nregulation\tO\nof\tO\nthe\tO\nheart\tO\n.\tO\n\nThey\tO\nsuggest\tO\nthat\tO\n,\tO\nin\tO\nnormal\tO\nconscious\tO\nrats\tO\n,\tO\nthe\tO\ncentral\tO\ntachycardia\tB-Disease\nof\tO\nbromocriptine\tB-Chemical\nappears\tO\nto\tO\npredominate\tO\nand\tO\nto\tO\nmask\tO\nthe\tO\nbradycardia\tB-Disease\nof\tO\nthis\tO\nagonist\tO\nat\tO\nperipheral\tO\ndopamine\tB-Chemical\nD2\tO\nreceptors\tO\n.\tO\n\nA\tO\ndevelopmental\tO\nanalysis\tO\nof\tO\nclonidine\tB-Chemical\n'\tO\ns\tO\neffects\tO\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nin\tO\ninfant\tO\nrats\tO\n.\tO\n\nUnder\tO\ncontrolled\tO\nconditions\tO\n,\tO\ninfant\tO\nrats\tO\nemit\tO\nultrasonic\tO\nvocalizations\tO\nduring\tO\nextreme\tO\ncold\tO\nexposure\tO\nand\tO\nafter\tO\nadministration\tO\nof\tO\nthe\tO\nalpha\tO\n(\tO\n2\tO\n)\tO\nadrenoceptor\tO\nagonist\tO\n,\tO\nclonidine\tB-Chemical\n.\tO\n\nPrevious\tO\ninvestigations\tO\nhave\tO\ndetermined\tO\nthat\tO\n,\tO\nin\tO\nresponse\tO\nto\tO\nclonidine\tB-Chemical\n,\tO\nultrasound\tO\nproduction\tO\nincreases\tO\nthrough\tO\nthe\tO\n2nd\tO\n-\tO\nweek\tO\npostpartum\tO\nand\tO\ndecreases\tO\nthereafter\tO\n.\tO\n\nGiven\tO\nthat\tO\nsympathetic\tO\nneural\tO\ndominance\tO\nexhibits\tO\na\tO\nsimilar\tO\ndevelopmental\tO\npattern\tO\n,\tO\nand\tO\ngiven\tO\nthat\tO\nclonidine\tB-Chemical\ninduces\tO\nsympathetic\tO\nwithdrawal\tO\nand\tO\nbradycardia\tB-Disease\n,\tO\nwe\tO\nhypothesized\tO\nthat\tO\nclonidine\tB-Chemical\n'\tO\ns\tO\ndevelopmental\tO\neffects\tO\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nwould\tO\nmirror\tO\neach\tO\nother\tO\n.\tO\n\nTherefore\tO\n,\tO\nin\tO\nthe\tO\npresent\tO\nexperiment\tO\n,\tO\nthe\tO\neffects\tO\nof\tO\nclonidine\tB-Chemical\nadministration\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nwere\tO\nexamined\tO\nin\tO\n2\tO\n-\tO\n,\tO\n8\tO\n-\tO\n,\tO\n15\tO\n-\tO\n,\tO\nand\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\n.\tO\n\nAge\tO\n-\tO\nrelated\tO\nchanges\tO\nin\tO\nultrasound\tO\nproduction\tO\ncorresponded\tO\nwith\tO\nchanges\tO\nin\tO\ncardiovascular\tO\nvariables\tO\n,\tO\nincluding\tO\nbaseline\tO\ncardiac\tO\nrate\tO\nand\tO\nclonidine\tB-Chemical\n-\tO\ninduced\tO\nbradycardia\tB-Disease\n.\tO\n\nThis\tO\nexperiment\tO\nis\tO\ndiscussed\tO\nwith\tO\nregard\tO\nto\tO\nthe\tO\nhypothesis\tO\nthat\tO\nultrasound\tO\nproduction\tO\nis\tO\nthe\tO\nacoustic\tO\nby\tO\n-\tO\nproduct\tO\nof\tO\na\tO\nphysiological\tO\nmaneuver\tO\nthat\tO\ncompensates\tO\nfor\tO\nclonidine\tB-Chemical\n'\tO\ns\tO\ndetrimental\tO\neffects\tO\non\tO\ncardiovascular\tO\nfunction\tO\n.\tO\n\nRecurrent\tO\nuse\tO\nof\tO\nnewer\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n.\tO\n\nThe\tO\nepidemiological\tO\nstudies\tO\nthat\tO\nassessed\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tB-Disease\n)\tO\nassociated\tO\nwith\tO\nnewer\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n(\tO\nOC\tB-Chemical\n)\tO\ndid\tO\nnot\tO\ndistinguish\tO\nbetween\tO\npatterns\tO\nof\tO\nOC\tB-Chemical\nuse\tO\n,\tO\nnamely\tO\nfirst\tO\n-\tO\ntime\tO\nusers\tO\n,\tO\nrepeaters\tO\nand\tO\nswitchers\tO\n.\tO\n\nData\tO\nfrom\tO\na\tO\nTransnational\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nwere\tO\nused\tO\nto\tO\nassess\tO\nthe\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nfor\tO\nthe\tO\nlatter\tO\npatterns\tO\nof\tO\nuse\tO\n,\tO\nwhile\tO\naccounting\tO\nfor\tO\nduration\tO\nof\tO\nuse\tO\n.\tO\n\nOver\tO\nthe\tO\nperiod\tO\n1993\tO\n-\tO\n1996\tO\n,\tO\n551\tO\ncases\tO\nof\tO\nVTE\tB-Disease\nwere\tO\nidentified\tO\nin\tO\nGermany\tO\nand\tO\nthe\tO\nUK\tO\nalong\tO\nwith\tO\n2066\tO\ncontrols\tO\n.\tO\n\nThe\tO\nadjusted\tO\nrate\tO\nratio\tO\nof\tO\nVTE\tB-Disease\nfor\tO\nrepeat\tO\nusers\tO\nof\tO\nthird\tO\ngeneration\tO\nOC\tB-Chemical\nwas\tO\n0\tO\n.\tO\n6\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n3\tO\n-\tO\n1\tO\n.\tO\n2\tO\n)\tO\nrelative\tO\nto\tO\nrepeat\tO\nusers\tO\nof\tO\nsecond\tO\ngeneration\tO\npills\tO\n,\tO\nwhereas\tO\nit\tO\nwas\tO\n1\tO\n.\tO\n3\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n7\tO\n-\tO\n2\tO\n.\tO\n4\tO\n)\tO\nfor\tO\nswitchers\tO\nfrom\tO\nsecond\tO\nto\tO\nthird\tO\ngeneration\tO\npills\tO\nrelative\tO\nto\tO\nswitchers\tO\nfrom\tO\nthird\tO\nto\tO\nsecond\tO\ngeneration\tO\npills\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nsecond\tO\nand\tO\nthird\tO\ngeneration\tO\nagents\tO\nare\tO\nassociated\tO\nwith\tO\nequivalent\tO\nrisks\tO\nof\tO\nVTE\tB-Disease\nwhen\tO\nthe\tO\nsame\tO\nagent\tO\nis\tO\nused\tO\nrepeatedly\tO\nafter\tO\ninterruption\tO\nperiods\tO\nor\tO\nwhen\tO\nusers\tO\nare\tO\nswitched\tO\nbetween\tO\nthe\tO\ntwo\tO\ngenerations\tO\nof\tO\npills\tO\n.\tO\n\nThese\tO\nanalyses\tO\nsuggest\tO\nthat\tO\nthe\tO\nhigher\tO\nrisk\tO\nobserved\tO\nfor\tO\nthe\tO\nnewer\tO\nOC\tB-Chemical\nin\tO\nother\tO\nstudies\tO\nmay\tO\nbe\tO\nthe\tO\nresult\tO\nof\tO\ninadequate\tO\ncomparisons\tO\nof\tO\npill\tO\nusers\tO\nwith\tO\ndifferent\tO\npatterns\tO\nof\tO\npill\tO\nuse\tO\n.\tO\n\nDifferential\tO\neffects\tO\nof\tO\nsystemically\tO\nadministered\tO\nketamine\tB-Chemical\nand\tO\nlidocaine\tB-Chemical\non\tO\ndynamic\tO\nand\tO\nstatic\tO\nhyperalgesia\tB-Disease\ninduced\tO\nby\tO\nintradermal\tO\ncapsaicin\tB-Chemical\nin\tO\nhumans\tO\n.\tO\n\nWe\tO\nhave\tO\nexamined\tO\nthe\tO\neffect\tO\nof\tO\nsystemic\tO\nadministration\tO\nof\tO\nketamine\tB-Chemical\nand\tO\nlidocaine\tB-Chemical\non\tO\nbrush\tO\n-\tO\nevoked\tO\n(\tO\ndynamic\tO\n)\tO\npain\tB-Disease\nand\tO\npunctate\tO\n-\tO\nevoked\tO\n(\tO\nstatic\tO\n)\tO\nhyperalgesia\tB-Disease\ninduced\tO\nby\tO\ncapsaicin\tB-Chemical\n.\tO\n\nCapsaicin\tB-Chemical\n100\tO\nmicrograms\tO\nwas\tO\ninjected\tO\nintradermally\tO\non\tO\nthe\tO\nvolar\tO\nforearm\tO\nfollowed\tO\nby\tO\nan\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusion\tO\nof\tO\nketamine\tB-Chemical\n(\tO\nbolus\tO\n0\tO\n.\tO\n1\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nover\tO\n10\tO\nmin\tO\nfollowed\tO\nby\tO\ninfusion\tO\nof\tO\n7\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nmin\tO\n-\tO\n1\tO\n)\tO\n,\tO\nlidocaine\tB-Chemical\n5\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nor\tO\nsaline\tO\nfor\tO\n50\tO\nmin\tO\n.\tO\n\nInfusion\tO\nstarted\tO\n15\tO\nmin\tO\nafter\tO\ninjection\tO\nof\tO\ncapsaicin\tB-Chemical\n.\tO\n\nThe\tO\nfollowing\tO\nwere\tO\nmeasured\tO\n:\tO\nspontaneous\tO\npain\tB-Disease\n,\tO\npain\tB-Disease\nevoked\tO\nby\tO\npunctate\tO\nand\tO\nbrush\tO\nstimuli\tO\n(\tO\nVAS\tO\n)\tO\n,\tO\nand\tO\nareas\tO\nof\tO\nbrush\tO\n-\tO\nevoked\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tB-Disease\n.\tO\n\nKetamine\tB-Chemical\nreduced\tO\nboth\tO\nthe\tO\narea\tO\nof\tO\nbrush\tO\n-\tO\nevoked\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tB-Disease\nsignificantly\tO\nand\tO\nit\tO\ntended\tO\nto\tO\nreduce\tO\nbrush\tO\n-\tO\nevoked\tO\npain\tO\n.\tO\n\nLidocaine\tB-Chemical\nreduced\tO\nthe\tO\narea\tO\nof\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tB-Disease\nsignificantly\tO\n.\tO\n\nIt\tO\ntended\tO\nto\tO\nreduce\tO\nVAS\tO\nscores\tO\nof\tO\nspontaneous\tO\npain\tB-Disease\nbut\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nevoked\tO\npain\tB-Disease\n.\tO\n\nThe\tO\ndifferential\tO\neffects\tO\nof\tO\nketamine\tB-Chemical\nand\tO\nlidocaine\tB-Chemical\non\tO\nstatic\tO\nand\tO\ndynamic\tO\nhyperalgesia\tB-Disease\nsuggest\tO\nthat\tO\nthe\tO\ntwo\tO\ntypes\tO\nof\tO\nhyperalgesia\tB-Disease\nare\tO\nmediated\tO\nby\tO\nseparate\tO\nmechanisms\tO\nand\tO\nhave\tO\na\tO\ndistinct\tO\npharmacology\tO\n.\tO\n\nDevelopment\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\naggressive\tB-Disease\nbehavior\tI-Disease\n:\tO\ncomparison\tO\nof\tO\nadult\tO\nmale\tO\nand\tO\nfemale\tO\nWistar\tO\nrats\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\n(\tO\n1\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nonce\tO\ndaily\tO\n)\tO\naggressive\tB-Disease\nbehavior\tI-Disease\nof\tO\nadult\tO\nmale\tO\nand\tO\nfemale\tO\nWistar\tO\nrats\tO\nobtained\tO\nfrom\tO\nthe\tO\nsame\tO\nbreeder\tO\nwas\tO\nstudied\tO\nin\tO\ntwo\tO\nconsecutive\tO\nsets\tO\n.\tO\n\nIn\tO\nmale\tO\nanimals\tO\n,\tO\nrepeated\tO\napomorphine\tB-Chemical\ntreatment\tO\ninduced\tO\na\tO\ngradual\tO\ndevelopment\tO\nof\tO\naggressive\tB-Disease\nbehavior\tI-Disease\nas\tO\nevidenced\tO\nby\tO\nthe\tO\nincreased\tO\nintensity\tO\nof\tO\naggressiveness\tB-Disease\nand\tO\nshortened\tO\nlatency\tO\nbefore\tO\nthe\tO\nfirst\tO\nattack\tO\ntoward\tO\nthe\tO\nopponent\tO\n.\tO\n\nIn\tO\nfemale\tO\nrats\tO\n,\tO\nonly\tO\na\tO\nweak\tO\ntendency\tO\ntoward\tO\naggressiveness\tB-Disease\nwas\tO\nfound\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\npresent\tO\nstudy\tO\ndemonstrates\tO\ngender\tO\ndifferences\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nthe\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tO\naggressive\tB-Disease\nbehavior\tI-Disease\nand\tO\nindicates\tO\nthat\tO\nthe\tO\nfemale\tO\nrats\tO\ndo\tO\nnot\tO\nfill\tO\nthe\tO\nvalidation\tO\ncriteria\tO\nfor\tO\nuse\tO\nin\tO\nthis\tO\nmethod\tO\n.\tO\n\nIntracranial\tB-Disease\naneurysms\tI-Disease\nand\tO\ncocaine\tB-Disease\nabuse\tI-Disease\n:\tO\nanalysis\tO\nof\tO\nprognostic\tO\nindicators\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\noutcome\tO\nof\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\nassociated\tO\nwith\tO\ncocaine\tB-Disease\nabuse\tI-Disease\nis\tO\nreportedly\tO\npoor\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nreview\tO\nof\tO\nadmissions\tO\nduring\tO\na\tO\n6\tO\n-\tO\nyear\tO\nperiod\tO\nrevealed\tO\n14\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nrelated\tO\naneurysms\tB-Disease\n.\tO\n\nThis\tO\ngroup\tO\nwas\tO\ncompared\tO\nwith\tO\na\tO\ncontrol\tO\ngroup\tO\nof\tO\n135\tO\npatients\tO\nwith\tO\nruptured\tB-Disease\naneurysms\tI-Disease\nand\tO\nno\tO\nhistory\tO\nof\tO\ncocaine\tB-Disease\nabuse\tI-Disease\n.\tO\n\nAge\tO\nat\tO\npresentation\tO\n,\tO\ntime\tO\nof\tO\nictus\tO\nafter\tO\nintoxication\tO\n,\tO\nHunt\tO\nand\tO\nHess\tO\ngrade\tO\nof\tO\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\n,\tO\nsize\tO\nof\tO\nthe\tO\naneurysm\tB-Disease\n,\tO\nlocation\tO\nof\tO\nthe\tO\naneurysm\tB-Disease\n,\tO\nand\tO\nthe\tO\nGlasgow\tO\nOutcome\tO\nScale\tO\nscore\tO\nwere\tO\nassessed\tO\nand\tO\ncompared\tO\n.\tO\n\nIn\tO\npatients\tO\nin\tO\nthe\tO\nstudy\tO\ngroup\tO\n,\tO\nall\tO\naneurysms\tB-Disease\nwere\tO\nlocated\tO\nin\tO\nthe\tO\nanterior\tO\ncirculation\tO\n.\tO\n\nThe\tO\nmajority\tO\nof\tO\nthese\tO\naneurysms\tB-Disease\nwere\tO\nsmaller\tO\nthan\tO\nthose\tO\nof\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\n8\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n08\tO\nmm\tO\nversus\tO\n11\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n4\tO\nmm\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nHunt\tO\nand\tO\nHess\tO\ngrade\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n005\tO\n)\tO\nand\tO\nage\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n007\tO\n)\tO\nwere\tO\nsignificant\tO\npredictors\tO\nof\tO\noutcome\tO\nfor\tO\nthe\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nrelated\tO\naneurysms\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nCocaine\tB-Chemical\nuse\tO\npredisposed\tO\naneurysmal\tB-Disease\nrupture\tI-Disease\nat\tO\na\tO\nsignificantly\tO\nearlier\tO\nage\tO\nand\tO\nin\tO\nmuch\tO\nsmaller\tO\naneurysms\tB-Disease\n.\tO\n\nEffect\tO\nof\tO\nintravenous\tO\nnimodipine\tB-Chemical\non\tO\nblood\tO\npressure\tO\nand\tO\noutcome\tO\nafter\tO\nacute\tB-Disease\nstroke\tI-Disease\n.\tO\n\nBACKGROUND\tO\nAND\tO\nPURPOSE\tO\n:\tO\nThe\tO\nIntravenous\tO\nNimodipine\tB-Chemical\nWest\tO\nEuropean\tO\nStroke\tB-Disease\nTrial\tO\n(\tO\nINWEST\tO\n)\tO\nfound\tO\na\tO\ncorrelation\tO\nbetween\tO\nnimodipine\tB-Chemical\n-\tO\ninduced\tO\nreduction\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\n(\tO\nBP\tO\n)\tO\nand\tO\nan\tO\nunfavorable\tO\noutcome\tO\nin\tO\nacute\tB-Disease\nstroke\tI-Disease\n.\tO\n\nWe\tO\nsought\tO\nto\tO\nconfirm\tO\nthis\tO\ncorrelation\tO\nwith\tO\nand\tO\nwithout\tO\nadjustment\tO\nfor\tO\nprognostic\tO\nvariables\tO\nand\tO\nto\tO\ninvestigate\tO\noutcome\tO\nin\tO\nsubgroups\tO\nwith\tO\nincreasing\tO\nlevels\tO\nof\tO\nBP\tB-Disease\nreduction\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nPatients\tO\nwith\tO\na\tO\nclinical\tO\ndiagnosis\tO\nof\tO\nischemic\tB-Disease\nstroke\tI-Disease\n(\tO\nwithin\tO\n24\tO\nhours\tO\n)\tO\nwere\tO\nconsecutively\tO\nallocated\tO\nto\tO\nreceive\tO\nplacebo\tO\n(\tO\nn\tO\n=\tO\n100\tO\n)\tO\n,\tO\n1\tO\nmg\tO\n/\tO\nh\tO\n(\tO\nlow\tO\n-\tO\ndose\tO\n)\tO\nnimodipine\tB-Chemical\n(\tO\nn\tO\n=\tO\n101\tO\n)\tO\n,\tO\nor\tO\n2\tO\nmg\tO\n/\tO\nh\tO\n(\tO\nhigh\tO\n-\tO\ndose\tO\n)\tO\nnimodipine\tB-Chemical\n(\tO\nn\tO\n=\tO\n94\tO\n)\tO\n.\tO\n\nNimodipine\tB-Chemical\ntreatment\tO\nresulted\tO\nin\tO\na\tO\nstatistically\tO\nsignificant\tO\nreduction\tB-Disease\nin\tI-Disease\nsystolic\tI-Disease\nBP\tI-Disease\n(\tO\nSBP\tO\n)\tO\nand\tO\ndiastolic\tO\nBP\tO\n(\tO\nDBP\tO\n)\tO\nfrom\tO\nbaseline\tO\ncompared\tO\nwith\tO\nplacebo\tO\nduring\tO\nthe\tO\nfirst\tO\nfew\tO\ndays\tO\n.\tO\n\nIn\tO\nmultivariate\tO\nanalysis\tO\n,\tO\na\tO\nsignificant\tO\ncorrelation\tO\nbetween\tO\nDBP\tB-Disease\nreduction\tI-Disease\nand\tO\nworsening\tO\nof\tO\nthe\tO\nneurological\tO\nscore\tO\nwas\tO\nfound\tO\nfor\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\n(\tO\nbeta\tO\n=\tO\n0\tO\n.\tO\n49\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n048\tO\n)\tO\n.\tO\n\nPatients\tO\nwith\tO\na\tO\nDBP\tB-Disease\nreduction\tI-Disease\nof\tO\n>\tO\nor\tO\n=\tO\n20\tO\n%\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\nhad\tO\na\tO\nsignificantly\tO\nincreased\tO\nadjusted\tO\nOR\tO\nfor\tO\nthe\tO\ncompound\tO\noutcome\tO\nvariable\tO\ndeath\tB-Disease\nor\tO\ndependency\tO\n(\tO\nBarthel\tO\nIndex\tO\n<\tO\n60\tO\n)\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n25\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n10\tO\n.\tO\n16\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n02\tO\nto\tO\n101\tO\n.\tO\n74\tO\n)\tO\nand\tO\ndeath\tB-Disease\nalone\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n9\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n4\tO\n.\tO\n336\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n131\tO\n16\tO\n.\tO\n619\tO\n)\tO\ncompared\tO\nwith\tO\nall\tO\nplacebo\tO\npatients\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n62\tO\n/\tO\n92\tO\nand\tO\n14\tO\n/\tO\n92\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDBP\tO\n,\tO\nbut\tO\nnot\tO\nSBP\tO\n,\tO\nreduction\tO\nwas\tO\nassociated\tO\nwith\tO\nneurological\tO\nworsening\tO\nafter\tO\nthe\tO\nintravenous\tO\nadministration\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\nnimodipine\tB-Chemical\nafter\tO\nacute\tB-Disease\nstroke\tI-Disease\n.\tO\n\nFor\tO\nlow\tO\n-\tO\ndose\tO\nnimodipine\tB-Chemical\n,\tO\nthe\tO\nresults\tO\nwere\tO\nnot\tO\nconclusive\tO\n.\tO\n\nThese\tO\nresults\tO\ndo\tO\nnot\tO\nconfirm\tO\nor\tO\nexclude\tO\na\tO\nneuroprotective\tO\nproperty\tO\nof\tO\nnimodipine\tB-Chemical\n.\tO\n\nNeonatal\tO\npyridoxine\tB-Chemical\nresponsive\tO\nconvulsions\tB-Disease\ndue\tO\nto\tO\nisoniazid\tB-Chemical\ntherapy\tO\n.\tO\n\nA\tO\n17\tO\n-\tO\nday\tO\n-\tO\nold\tO\ninfant\tO\non\tO\nisoniazid\tB-Chemical\ntherapy\tO\n13\tO\nmg\tO\n/\tO\nkg\tO\ndaily\tO\nfrom\tO\nbirth\tO\nbecause\tO\nof\tO\nmaternal\tO\ntuberculosis\tB-Disease\nwas\tO\nadmitted\tO\nafter\tO\n4\tO\ndays\tO\nof\tO\nclonic\tB-Disease\nfits\tI-Disease\n.\tO\n\nThe\tO\nfits\tB-Disease\nceased\tO\nwithin\tO\n4\tO\nhours\tO\nof\tO\nadministering\tO\nintramuscular\tO\npyridoxine\tB-Chemical\n,\tO\nsuggesting\tO\nan\tO\naetiology\tO\nof\tO\npyridoxine\tB-Chemical\ndeficiency\tO\nsecondary\tO\nto\tO\nisoniazid\tB-Chemical\nmedication\tO\n.\tO\n\nKetamine\tB-Chemical\nsedation\tO\nfor\tO\nthe\tO\nreduction\tO\nof\tO\nchildren\tO\n'\tO\ns\tO\nfractures\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThere\tO\nrecently\tO\nhas\tO\nbeen\tO\na\tO\nresurgence\tO\nin\tO\nthe\tO\nutilization\tO\nof\tO\nketamine\tB-Chemical\n,\tO\na\tO\nunique\tO\nanesthetic\tO\n,\tO\nfor\tO\nemergency\tO\n-\tO\ndepartment\tO\nprocedures\tO\nrequiring\tO\nsedation\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nketamine\tB-Chemical\nfor\tO\nsedation\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nchildren\tO\n'\tO\ns\tO\nfractures\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tO\n\nMETHODS\tO\n:\tO\nOne\tO\nhundred\tO\nand\tO\nfourteen\tO\nchildren\tO\n(\tO\naverage\tO\nage\tO\n,\tO\n5\tO\n.\tO\n3\tO\nyears\tO\n;\tO\nrange\tO\n,\tO\ntwelve\tO\nmonths\tO\nto\tO\nten\tO\nyears\tO\nand\tO\nten\tO\nmonths\tO\n)\tO\nwho\tO\nunderwent\tO\nclosed\tO\nreduction\tO\nof\tO\nan\tO\nisolated\tO\nfracture\tB-Disease\nor\tO\ndislocation\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nat\tO\na\tO\nlevel\tO\n-\tO\nI\tO\ntrauma\tB-Disease\ncenter\tO\nwere\tO\nprospectively\tO\nevaluated\tO\n.\tO\n\nKetamine\tB-Chemical\nhydrochloride\tI-Chemical\nwas\tO\nadministered\tO\nintravenously\tO\n(\tO\nat\tO\na\tO\ndose\tO\nof\tO\ntwo\tO\nmilligrams\tO\nper\tO\nkilogram\tO\nof\tO\nbody\tO\nweight\tO\n)\tO\nin\tO\nninety\tO\n-\tO\nnine\tO\nof\tO\nthe\tO\npatients\tO\nand\tO\nintramuscularly\tO\n(\tO\nat\tO\na\tO\ndose\tO\nof\tO\nfour\tO\nmilligrams\tO\nper\tO\nkilogram\tO\nof\tO\nbody\tO\nweight\tO\n)\tO\nin\tO\nthe\tO\nother\tO\nfifteen\tO\n.\tO\n\nAny\tO\npain\tB-Disease\nduring\tO\nthe\tO\nreduction\tO\nwas\tO\nrated\tO\nby\tO\nthe\tO\northopaedic\tO\nsurgeon\tO\ntreating\tO\nthe\tO\npatient\tO\naccording\tO\nto\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nof\tO\nEastern\tO\nOntario\tO\nPain\tB-Disease\nScale\tO\n(\tO\nCHEOPS\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\naverage\tO\ntime\tO\nfrom\tO\nintravenous\tO\nadministration\tO\nof\tO\nketamine\tB-Chemical\nto\tO\nmanipulation\tO\nof\tO\nthe\tO\nfracture\tB-Disease\nor\tO\ndislocation\tB-Disease\nwas\tO\none\tO\nminute\tO\nand\tO\nthirty\tO\n-\tO\nsix\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\ntwenty\tO\nseconds\tO\nto\tO\nfive\tO\nminutes\tO\n)\tO\n,\tO\nand\tO\nthe\tO\naverage\tO\ntime\tO\nfrom\tO\nintramuscular\tO\nadministration\tO\nto\tO\nmanipulation\tO\nwas\tO\nfour\tO\nminutes\tO\nand\tO\nforty\tO\n-\tO\ntwo\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\nsixty\tO\nseconds\tO\nto\tO\nfifteen\tO\nminutes\tO\n)\tO\n.\tO\n\nThe\tO\naverage\tO\nscore\tO\naccording\tO\nto\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nof\tO\nEastern\tO\nOntario\tO\nPain\tB-Disease\nScale\tO\nwas\tO\n6\tO\n.\tO\n4\tO\npoints\tO\n(\tO\nrange\tO\n,\tO\n5\tO\nto\tO\n10\tO\npoints\tO\n)\tO\n,\tO\nreflecting\tO\nminimal\tO\nor\tO\nno\tO\npain\tB-Disease\nduring\tO\nfracture\tB-Disease\nreduction\tO\n.\tO\n\nAdequate\tO\nfracture\tB-Disease\nreduction\tO\nwas\tO\nobtained\tO\nin\tO\n111\tO\nof\tO\nthe\tO\nchildren\tO\n.\tO\n\nMinor\tO\nside\tO\neffects\tO\nincluded\tO\nnausea\tB-Disease\n(\tO\nthirteen\tO\npatients\tO\n)\tO\n,\tO\nemesis\tB-Disease\n(\tO\neight\tO\nof\tO\nthe\tO\nthirteen\tO\npatients\tO\nwith\tO\nnausea\tB-Disease\n)\tO\n,\tO\nclumsiness\tB-Disease\n(\tO\nevident\tO\nas\tO\nataxic\tB-Disease\nmovements\tI-Disease\nin\tO\nten\tO\npatients\tO\n)\tO\n,\tO\nand\tO\ndysphoric\tB-Disease\nreaction\tI-Disease\n(\tO\none\tO\npatient\tO\n)\tO\n.\tO\n\nNo\tO\nlong\tO\n-\tO\nterm\tO\nsequelae\tO\nwere\tO\nnoted\tO\n,\tO\nand\tO\nno\tO\npatients\tO\nhad\tO\nhallucinations\tB-Disease\nor\tO\nnightmares\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nKetamine\tB-Chemical\nreliably\tO\n,\tO\nsafely\tO\n,\tO\nand\tO\nquickly\tO\nprovided\tO\nadequate\tO\nsedation\tO\nto\tO\neffectively\tO\nfacilitate\tO\nthe\tO\nreduction\tO\nof\tO\nchildren\tO\n'\tO\ns\tO\nfractures\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nat\tO\nour\tO\ninstitution\tO\n.\tO\n\nKetamine\tB-Chemical\nshould\tO\nonly\tO\nbe\tO\nused\tO\nin\tO\nan\tO\nenvironment\tO\nsuch\tO\nas\tO\nthe\tO\nemergency\tO\ndepartment\tO\n,\tO\nwhere\tO\nproper\tO\none\tO\n-\tO\non\tO\n-\tO\none\tO\nmonitoring\tO\nis\tO\nused\tO\nand\tO\nboard\tO\n-\tO\ncertified\tO\nphysicians\tO\nskilled\tO\nin\tO\nairway\tO\nmanagement\tO\nare\tO\ndirectly\tO\ninvolved\tO\nin\tO\nthe\tO\ncare\tO\nof\tO\nthe\tO\npatient\tO\n.\tO\n\nCyclosporine\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\n-\tO\nassociated\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n(\tO\nTMA\tB-Disease\n)\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\ncyclosporine\tB-Chemical\nhas\tO\nbeen\tO\nwell\tO\ndocumented\tO\n.\tO\n\nTreatments\tO\nhave\tO\nincluded\tO\ndiscontinuation\tO\nor\tO\nreduction\tO\nof\tO\ncyclosporine\tB-Chemical\ndose\tO\nwith\tO\nor\tO\nwithout\tO\nconcurrent\tO\nplasma\tO\nexchange\tO\n,\tO\nplasma\tO\ninfusion\tO\n,\tO\nanticoagulation\tO\n,\tO\nand\tO\nintravenous\tO\nimmunoglobulin\tO\nG\tO\ninfusion\tO\n.\tO\n\nThe\tO\nlast\tO\ndecade\tO\nhas\tO\nseen\tO\nthe\tO\nemergence\tO\nof\tO\ntacrolimus\tB-Chemical\nas\tO\na\tO\npotent\tO\nimmunosuppressive\tO\nagent\tO\nwith\tO\nmechanisms\tO\nof\tO\naction\tO\nvirtually\tO\nidentical\tO\nto\tO\nthose\tO\nof\tO\ncyclosporine\tB-Chemical\n.\tO\n\nAs\tO\na\tO\nresult\tO\n,\tO\nswitching\tO\nto\tO\ntacrolimus\tB-Chemical\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nbe\tO\na\tO\nviable\tO\ntherapeutic\tO\noption\tO\nin\tO\nthe\tO\nsetting\tO\nof\tO\ncyclosporine\tB-Chemical\n-\tO\ninduced\tO\nTMA\tB-Disease\n.\tO\n\nWith\tO\nthe\tO\nmore\tO\nwidespread\tO\napplication\tO\nof\tO\ntacrolimus\tB-Chemical\nin\tO\norgan\tO\ntransplantation\tO\n,\tO\ntacrolimus\tB-Chemical\n-\tO\nassociated\tO\nTMA\tB-Disease\nhas\tO\nalso\tO\nbeen\tO\nrecognized\tO\n.\tO\n\nHowever\tO\n,\tO\nliterature\tO\nregarding\tO\nthe\tO\nincidence\tO\nof\tO\nthe\tO\nrecurrence\tO\nof\tO\nTMA\tB-Disease\nin\tO\npatients\tO\nexposed\tO\nsequentially\tO\nto\tO\ncyclosporine\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\nis\tO\nlimited\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\nliving\tO\ndonor\tO\nrenal\tO\ntransplant\tO\nrecipient\tO\nwho\tO\ndeveloped\tO\ncyclosporine\tB-Chemical\n-\tO\ninduced\tO\nTMA\tB-Disease\nthat\tO\nresponded\tO\nto\tO\nthe\tO\nwithdrawal\tO\nof\tO\ncyclosporine\tB-Chemical\nin\tO\nconjunction\tO\nwith\tO\nplasmapheresis\tO\nand\tO\nfresh\tO\nfrozen\tO\nplasma\tO\nreplacement\tO\ntherapy\tO\n.\tO\n\nIntroduction\tO\nof\tO\ntacrolimus\tB-Chemical\nas\tO\nan\tO\nalternative\tO\nimmunosuppressive\tO\nagent\tO\nresulted\tO\nin\tO\nthe\tO\nrecurrence\tO\nof\tO\nTMA\tB-Disease\nand\tO\nthe\tO\nsubsequent\tO\nloss\tO\nof\tO\nthe\tO\nrenal\tO\nallograft\tO\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\nswitched\tO\nfrom\tO\ncyclosporine\tB-Chemical\nto\tO\ntacrolimus\tB-Chemical\nor\tO\nvice\tO\nversa\tO\nshould\tO\nbe\tO\nclosely\tO\nmonitored\tO\nfor\tO\nthe\tO\nsigns\tO\nand\tO\nsymptoms\tO\nof\tO\nrecurrent\tO\nTMA\tB-Disease\n.\tO\n\nAnalgesic\tO\neffect\tO\nof\tO\nintravenous\tO\nketamine\tB-Chemical\nin\tO\ncancer\tB-Disease\npatients\tO\non\tO\nmorphine\tB-Chemical\ntherapy\tO\n:\tO\na\tO\nrandomized\tO\n,\tO\ncontrolled\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nPain\tB-Disease\nnot\tO\nresponsive\tO\nto\tO\nmorphine\tB-Chemical\nis\tO\noften\tO\nproblematic\tO\n.\tO\n\nAnimal\tO\nand\tO\nclinical\tO\nstudies\tO\nhave\tO\nsuggested\tO\nthat\tO\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tB-Chemical\n)\tO\nantagonists\tO\n,\tO\nsuch\tO\nas\tO\nketamine\tB-Chemical\n,\tO\nmay\tO\nbe\tO\neffective\tO\nin\tO\nimproving\tO\nopioid\tO\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tB-Disease\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tB-Disease\npain\tI-Disease\n.\tO\n\nA\tO\nslow\tO\nbolus\tO\nof\tO\nsubhypnotic\tO\ndoses\tO\nof\tO\nketamine\tB-Chemical\n(\tO\n0\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nor\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ngiven\tO\nto\tO\n10\tO\ncancer\tB-Disease\npatients\tO\nwhose\tO\npain\tB-Disease\nwas\tO\nunrelieved\tO\nby\tO\nmorphine\tB-Chemical\nin\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nPain\tB-Disease\nintensity\tO\non\tO\na\tO\n0\tO\nto\tO\n10\tO\nnumerical\tO\nscale\tO\n;\tO\nnausea\tB-Disease\nand\tO\nvomiting\tB-Disease\n,\tO\ndrowsiness\tO\n,\tO\nconfusion\tB-Disease\n,\tO\nand\tO\ndry\tB-Disease\nmouth\tI-Disease\n,\tO\nusing\tO\na\tO\nscale\tO\nfrom\tO\n0\tO\nto\tO\n3\tO\n(\tO\nnot\tO\nat\tO\nall\tO\n,\tO\nslight\tO\n,\tO\na\tO\nlot\tO\n,\tO\nawful\tO\n)\tO\n;\tO\nMini\tO\n-\tO\nMental\tO\nState\tO\nExamination\tO\n(\tO\nMMSE\tO\n)\tO\n(\tO\n0\tO\n-\tO\n30\tO\n)\tO\n;\tO\nand\tO\narterial\tO\npressure\tO\nwere\tO\nrecorded\tO\nbefore\tO\nadministration\tO\nof\tO\ndrugs\tO\n(\tO\nT0\tO\n)\tO\nand\tO\nafter\tO\n30\tO\nminutes\tO\n(\tO\nT30\tO\n)\tO\n,\tO\n60\tO\nminutes\tO\n(\tO\nT60\tO\n)\tO\n,\tO\n120\tO\nminutes\tO\n(\tO\nT120\tO\n)\tO\n,\tO\nand\tO\n180\tO\nminutes\tO\n(\tO\nT180\tO\n)\tO\n.\tO\n\nKetamine\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nsaline\tO\nsolution\tO\n,\tO\nsignificantly\tO\nreduced\tO\nthe\tO\npain\tB-Disease\nintensity\tO\nin\tO\nalmost\tO\nall\tO\nthe\tO\npatients\tO\nat\tO\nboth\tO\ndoses\tO\n.\tO\n\nHallucinations\tB-Disease\noccurred\tO\nin\tO\n4\tO\npatients\tO\n,\tO\nand\tO\nan\tO\nunpleasant\tO\nsensation\tO\n(\tO\n\"\tO\nempty\tO\nhead\tO\n\"\tO\n)\tO\nwas\tO\nalso\tO\nreported\tO\nby\tO\n2\tO\npatients\tO\n.\tO\n\nThese\tO\nepisodes\tO\nreversed\tO\nafter\tO\nthe\tO\nadministration\tO\nof\tO\ndiazepam\tB-Chemical\n1\tO\nmg\tO\nintravenously\tO\n.\tO\n\nSignificant\tO\nincreases\tO\nin\tO\ndrowsiness\tO\nwere\tO\nreported\tO\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nketamine\tB-Chemical\nin\tO\nboth\tO\ngroups\tO\nand\tO\nwere\tO\nmore\tO\nmarked\tO\nwith\tO\nketamine\tB-Chemical\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nA\tO\nsignificant\tO\ndifference\tO\nin\tO\nMMSE\tO\nwas\tO\nobserved\tO\nat\tO\nT30\tO\nin\tO\npatients\tO\nwho\tO\nreceived\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\nof\tO\nketamine\tB-Chemical\n.\tO\n\nKetamine\tB-Chemical\ncan\tO\nimprove\tO\nmorphine\tB-Chemical\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tB-Disease\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tB-Disease\npain\tI-Disease\n.\tO\n\nThis\tO\nobservation\tO\nshould\tO\nbe\tO\ntested\tO\nin\tO\nstudies\tO\nof\tO\nprolonged\tO\nketamine\tB-Chemical\nadministration\tO\n.\tO\n\nPaclitaxel\tB-Chemical\n,\tO\ncisplatin\tB-Chemical\n,\tO\nand\tO\ngemcitabine\tB-Chemical\ncombination\tO\nchemotherapy\tO\nwithin\tO\na\tO\nmultidisciplinary\tO\ntherapeutic\tO\napproach\tO\nin\tO\nmetastatic\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nCisplatin\tB-Chemical\n-\tO\nbased\tO\nchemotherapy\tO\ncombinations\tO\nimprove\tO\nquality\tO\nof\tO\nlife\tO\nand\tO\nsurvival\tO\nin\tO\nadvanced\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\n(\tO\nNSCLC\tB-Disease\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\nfeasibility\tO\n,\tO\nresponse\tO\nrate\tO\n,\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\na\tO\npaclitaxel\tB-Chemical\n,\tO\ncisplatin\tB-Chemical\n,\tO\nand\tO\ngemcitabine\tB-Chemical\ncombination\tO\nto\tO\ntreat\tO\nmetastatic\tO\nNSCLC\tB-Disease\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\nconsecutive\tO\nchemotherapy\tO\n-\tO\nnaive\tO\npatients\tO\nwith\tO\nStage\tO\nIV\tO\nNSCLC\tB-Disease\nand\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nperformance\tO\nstatus\tO\nof\tO\n0\tO\n-\tO\n2\tO\nwere\tO\ntreated\tO\nwith\tO\na\tO\ncombination\tO\nof\tO\npaclitaxel\tB-Chemical\n(\tO\n135\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n3\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\ncisplatin\tB-Chemical\n(\tO\n120\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n6\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\nand\tO\ngemcitabine\tB-Chemical\n(\tO\n800\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n30\tO\nminutes\tO\n)\tO\non\tO\nDays\tO\n1\tO\nand\tO\n8\tO\n,\tO\nevery\tO\n4\tO\nweeks\tO\n.\tO\n\nAlthough\tO\nresponding\tO\npatients\tO\nwere\tO\nscheduled\tO\nto\tO\nreceive\tO\nconsolidation\tO\nradiotherapy\tO\nand\tO\n24\tO\npatients\tO\nreceived\tO\npreplanned\tO\nsecond\tO\n-\tO\nline\tO\nchemotherapy\tO\nafter\tO\ndisease\tO\nprogression\tO\n,\tO\nthe\tO\nresponse\tO\nand\tO\ntoxicity\tB-Disease\nrates\tO\nreported\tO\nrefer\tO\nonly\tO\nto\tO\nthe\tO\nchemotherapy\tO\nregimen\tO\ngiven\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\nthe\tO\npatients\tO\nwere\tO\nexamined\tO\nfor\tO\ntoxicity\tB-Disease\n;\tO\n34\tO\nwere\tO\nexaminable\tO\nfor\tO\nresponse\tO\n.\tO\n\nAfter\tO\n154\tO\ncourses\tO\nof\tO\ntherapy\tO\n,\tO\nthe\tO\nmedian\tO\ndose\tO\nintensity\tO\nwas\tO\n131\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\npaclitaxel\tB-Chemical\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\n117\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\ncisplatin\tB-Chemical\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nand\tO\n1378\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\ngemcitabine\tB-Chemical\n(\tO\n86\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nWorld\tO\nHealth\tO\nOrganization\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tB-Disease\nand\tO\nthrombocytopenia\tB-Disease\noccurred\tO\nin\tO\n39\tO\n.\tO\n9\tO\n%\tO\nand\tO\n11\tO\n.\tO\n4\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nrespectively\tO\n.\tO\n\nThere\tO\nwas\tO\none\tO\ntreatment\tO\n-\tO\nrelated\tO\ndeath\tB-Disease\n.\tO\n\nNonhematologic\tO\ntoxicities\tB-Disease\nwere\tO\nmild\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tO\nof\tO\npaclitaxel\tB-Chemical\n,\tO\ncisplatin\tB-Chemical\n,\tO\nand\tO\ngemcitabine\tB-Chemical\nis\tO\nwell\tO\ntolerated\tO\nand\tO\nshows\tO\nhigh\tO\nactivity\tO\nin\tO\nmetastatic\tO\nNSCLC\tB-Disease\n.\tO\n\nThis\tO\ntreatment\tO\nmerits\tO\nfurther\tO\ncomparison\tO\nwith\tO\nother\tO\ncisplatin\tB-Chemical\n-\tO\nbased\tO\nregimens\tO\n.\tO\n\nSerotonergic\tO\nantidepressants\tO\nand\tO\nurinary\tB-Disease\nincontinence\tI-Disease\n.\tO\n\nMany\tO\nnew\tO\nserotonergic\tB-Chemical\nantidepressants\tI-Chemical\nhave\tO\nbeen\tO\nintroduced\tO\nover\tO\nthe\tO\npast\tO\ndecade\tO\n.\tO\n\nAlthough\tO\nurinary\tB-Disease\nincontinence\tI-Disease\nis\tO\nlisted\tO\nas\tO\none\tO\nside\tO\neffect\tO\nof\tO\nthese\tO\ndrugs\tO\nin\tO\ntheir\tO\npackage\tO\ninserts\tO\nthere\tO\nis\tO\nonly\tO\none\tO\nreport\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nThis\tO\nconcerns\tO\n2\tO\nmale\tO\npatients\tO\nwho\tO\nexperienced\tO\nincontinence\tB-Disease\nwhile\tO\ntaking\tO\nvenlafaxine\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\npaper\tO\nthe\tO\nauthors\tO\ndescribe\tO\n2\tO\nfemale\tO\npatients\tO\nwho\tO\ndeveloped\tO\nincontinence\tB-Disease\nsecondary\tO\nto\tO\nthe\tO\nselective\tO\nserotonin\tB-Chemical\nreuptake\tO\ninhibitors\tO\nparoxetine\tB-Chemical\nand\tO\nsertraline\tB-Chemical\n,\tO\nas\tO\nwell\tO\nas\tO\na\tO\nthird\tO\nwho\tO\ndeveloped\tO\nthis\tO\nside\tO\neffect\tO\non\tO\nvenlafaxine\tB-Chemical\n.\tO\n\nIn\tO\n2\tO\nof\tO\nthe\tO\n3\tO\ncases\tO\nthe\tO\npatients\tO\nwere\tO\nalso\tO\ntaking\tO\nlithium\tB-Chemical\ncarbonate\tI-Chemical\nand\tO\nbeta\tO\n-\tO\nblockers\tO\n,\tO\nboth\tO\nof\tO\nwhich\tO\ncould\tO\nhave\tO\ncontributed\tO\nto\tO\nthe\tO\nincontinence\tB-Disease\n.\tO\n\nAnimal\tO\nstudies\tO\nsuggest\tO\nthat\tO\nincontinence\tO\nsecondary\tO\nto\tO\nserotonergic\tB-Chemical\nantidepressants\tI-Chemical\ncould\tO\nbe\tO\nmediated\tO\nby\tO\nthe\tO\n5HT4\tO\nreceptors\tO\nfound\tO\non\tO\nthe\tO\nbladder\tO\n.\tO\n\nAcute\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n:\tO\ndifferential\tO\nsensitivity\tO\nof\tO\nsix\tO\ninbred\tO\nmouse\tO\nstrains\tO\n.\tO\n\nMature\tO\nmale\tO\nand\tO\nfemale\tO\nmice\tO\nfrom\tO\nsix\tO\ninbred\tO\nstains\tO\nwere\tO\ntested\tO\nfor\tO\nsusceptibility\tO\nto\tO\nbehavioral\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nCocaine\tB-Chemical\nwas\tO\ninjected\tO\nip\tO\nover\tO\na\tO\nrange\tO\nof\tO\ndoses\tO\n(\tO\n50\tO\n-\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\nbehavior\tO\nwas\tO\nmonitored\tO\nfor\tO\n20\tO\nminutes\tO\n.\tO\n\nSeizure\tO\nend\tO\npoints\tO\nincluded\tO\nlatency\tO\nto\tO\nforelimb\tO\nor\tO\nhindlimb\tO\nclonus\tO\n,\tO\nlatency\tO\nto\tO\nclonic\tO\nrunning\tO\nseizure\tB-Disease\nand\tO\nlatency\tO\nto\tO\njumping\tO\nbouncing\tO\nseizure\tB-Disease\n.\tO\n\nAdditionally\tO\n,\tO\nlevels\tO\nof\tO\ncocaine\tB-Chemical\ndetermined\tO\nin\tO\nhippocampus\tO\nand\tO\ncortex\tO\nwere\tO\nnot\tO\ndifferent\tO\nbetween\tO\nsensitive\tO\nand\tO\nresistant\tO\nstrains\tO\n.\tO\n\nAdditional\tO\nstudies\tO\nof\tO\nthese\tO\nmurine\tO\nstrains\tO\nmay\tO\nbe\tO\nuseful\tO\nfor\tO\ninvestigating\tO\ngenetic\tO\ninfluences\tO\non\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\n.\tO\n\nHypotension\tB-Disease\nfollowing\tO\nthe\tO\ninitiation\tO\nof\tO\ntizanidine\tB-Chemical\nin\tO\na\tO\npatient\tO\ntreated\tO\nwith\tO\nan\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitor\tO\nfor\tO\nchronic\tO\nhypertension\tB-Disease\n.\tO\n\nCentrally\tO\nacting\tO\nalpha\tO\n-\tO\n2\tO\nadrenergic\tO\nagonists\tO\nare\tO\none\tO\nof\tO\nseveral\tO\npharmacologic\tO\nagents\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nspasticity\tB-Disease\nrelated\tO\nto\tO\ndisorders\tB-Disease\nof\tI-Disease\nthe\tI-Disease\ncentral\tI-Disease\nnervous\tI-Disease\nsystem\tI-Disease\n.\tO\n\nIn\tO\naddition\tO\nto\tO\ntheir\tO\neffects\tO\non\tO\nspasticity\tB-Disease\n,\tO\ncertain\tO\nadverse\tO\ncardiorespiratory\tO\neffects\tO\nhave\tO\nbeen\tO\nreported\tO\n.\tO\n\nAdults\tO\nchronically\tO\ntreated\tO\nwith\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitors\tO\nmay\tO\nhave\tO\na\tO\nlimited\tO\nability\tO\nto\tO\nrespond\tO\nto\tO\nhypotension\tB-Disease\nwhen\tO\nthe\tO\nsympathetic\tO\nresponse\tO\nis\tO\nsimultaneously\tO\nblocked\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\n10\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nchronically\tO\ntreated\tO\nwith\tO\nlisinopril\tB-Chemical\n,\tO\nan\tO\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitor\tO\n,\tO\nto\tO\ncontrol\tO\nhypertension\tB-Disease\nwho\tO\ndeveloped\tO\nhypotension\tB-Disease\nfollowing\tO\nthe\tO\naddition\tO\nof\tO\ntizanidine\tB-Chemical\n,\tO\nan\tO\nalpha\tO\n-\tO\n2\tO\nagonist\tO\n,\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nspasticity\tB-Disease\n.\tO\n\nThe\tO\npossible\tO\ninteraction\tO\nof\tO\ntizanidine\tB-Chemical\nand\tO\nother\tO\nantihypertensive\tO\nagents\tO\nshould\tO\nbe\tO\nkept\tO\nin\tO\nmind\tO\nwhen\tO\nprescribing\tO\ntherapy\tO\nto\tO\ntreat\tO\neither\tO\nhypertension\tB-Disease\nor\tO\nspasticity\tB-Disease\nin\tO\nsuch\tO\npatients\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nselected\tO\nfor\tO\ndifferential\tO\nsensitivities\tO\nto\tO\nbeta\tB-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nare\tO\nalso\tO\ndifferentially\tO\nsensitive\tO\nto\tO\nvarious\tO\npharmacological\tO\neffects\tO\nof\tO\nother\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tO\nligands\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nwere\tO\nselectively\tO\nbred\tO\naccording\tO\nto\tO\ntheir\tO\nsensitivity\tO\n(\tO\nBS\tO\nline\tO\n)\tO\nor\tO\nresistance\tO\n(\tO\nBR\tO\nline\tO\n)\tO\nto\tO\nseizures\tB-Disease\ninduced\tO\nby\tO\na\tO\nsingle\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tO\nof\tO\nmethyl\tB-Chemical\nbeta\tI-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\ncarboxylate\tI-Chemical\n(\tO\nbeta\tB-Chemical\n-\tI-Chemical\nCCM\tI-Chemical\n)\tO\n,\tO\nan\tO\ninverse\tO\nagonist\tO\nof\tO\nthe\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tO\nbenzodiazepine\tB-Chemical\nsite\tO\n.\tO\n\nOur\tO\naim\tO\nwas\tO\nto\tO\ncharacterize\tO\nboth\tO\nlines\tO\n'\tO\nsensitivities\tO\nto\tO\nvarious\tO\nphysiological\tO\neffects\tO\nof\tO\nother\tO\nligands\tO\nof\tO\nthe\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tO\n.\tO\n\nWe\tO\nmeasured\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\nanxiolysis\tO\nwith\tO\nthe\tO\nelevated\tO\nplus\tO\n-\tO\nmaze\tO\ntest\tO\n,\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\nsedation\tO\nby\tO\nrecording\tO\nthe\tO\nvigilance\tO\nstates\tO\n,\tO\nand\tO\npicrotoxin\tB-Chemical\n-\tO\nand\tO\npentylenetetrazol\tB-Chemical\n-\tO\ninduced\tO\nseizures\tB-Disease\nafter\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\n.\tO\n\nResults\tO\npresented\tO\nhere\tO\nshow\tO\nthat\tO\nthe\tO\ndifferential\tO\nsensitivities\tO\nof\tO\nBS\tO\nand\tO\nBR\tO\nlines\tO\nto\tO\nbeta\tB-Chemical\n-\tI-Chemical\nCCM\tI-Chemical\ncan\tO\nbe\tO\nextended\tO\nto\tO\ndiazepam\tB-Chemical\n,\tO\npicrotoxin\tB-Chemical\n,\tO\nand\tO\npentylenetetrazol\tB-Chemical\n,\tO\nsuggesting\tO\na\tO\ngenetic\tO\nselection\tO\nof\tO\na\tO\ngeneral\tO\nsensitivity\tO\nand\tO\nresistance\tO\nto\tO\nseveral\tO\nligands\tO\nof\tO\nthe\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tO\n.\tO\n\nPropylthiouracil\tB-Chemical\n-\tO\ninduced\tO\nperinuclear\tO\n-\tO\nstaining\tO\nantineutrophil\tO\ncytoplasmic\tO\nautoantibody\tO\n-\tO\npositive\tO\nvasculitis\tB-Disease\nin\tO\nconjunction\tO\nwith\tO\npericarditis\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\npropylthiouracil\tB-Chemical\n-\tO\ninduced\tO\nvasculitis\tB-Disease\nmanifesting\tO\nwith\tO\npericarditis\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\npresent\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\na\tO\nwoman\tO\nwith\tO\nhyperthyroidism\tB-Disease\ntreated\tO\nwith\tO\npropylthiouracil\tB-Chemical\nin\tO\nwhom\tO\na\tO\nsyndrome\tO\nof\tO\npericarditis\tB-Disease\n,\tO\nfever\tB-Disease\n,\tO\nand\tO\nglomerulonephritis\tB-Disease\ndeveloped\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\nhad\tO\na\tO\nfebrile\tB-Disease\nillness\tI-Disease\nand\tO\nevidence\tO\nof\tO\npericarditis\tB-Disease\n,\tO\nwhich\tO\nwas\tO\nconfirmed\tO\nby\tO\nbiopsy\tO\n.\tO\n\nPropylthiouracil\tB-Chemical\ntherapy\tO\nwas\tO\nwithdrawn\tO\n,\tO\nand\tO\nshe\tO\nwas\tO\ntreated\tO\nwith\tO\na\tO\n1\tO\n-\tO\nmonth\tO\ncourse\tO\nof\tO\nprednisone\tB-Chemical\n,\tO\nwhich\tO\nalleviated\tO\nher\tO\nsymptoms\tO\n.\tO\n\nA\tO\nliterature\tO\nreview\tO\nrevealed\tO\nno\tO\nprior\tO\nreports\tO\nof\tO\npericarditis\tB-Disease\nin\tO\nanti\tO\n-\tO\nMPO\tO\npANCA\tO\n-\tO\npositive\tO\nvasculitis\tB-Disease\nassociated\tO\nwith\tO\npropylthio\tB-Chemical\n-\tI-Chemical\nuracil\tI-Chemical\ntherapy\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nPericarditis\tB-Disease\nmay\tO\nbe\tO\nthe\tO\ninitial\tO\nmanifestation\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nvasculitis\tB-Disease\nattributable\tO\nto\tO\npropylthio\tB-Chemical\n-\tI-Chemical\nuracil\tI-Chemical\ntherapy\tO\n.\tO\n\nRepeated\tO\ntransient\tO\nanuria\tB-Disease\nfollowing\tO\nlosartan\tB-Chemical\nadministration\tO\nin\tO\na\tO\npatient\tO\nwith\tO\na\tO\nsolitary\tO\nkidney\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n70\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nhypertensive\tO\nman\tO\nwith\tO\na\tO\nsolitary\tO\nkidney\tO\nand\tO\nchronic\tB-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\nwho\tO\ndeveloped\tO\ntwo\tO\nepisodes\tO\nof\tO\ntransient\tO\nanuria\tB-Disease\nafter\tO\nlosartan\tB-Chemical\nadministration\tO\n.\tO\n\nHe\tO\nwas\tO\nhospitalized\tO\nfor\tO\na\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwith\tO\npulmonary\tB-Disease\nedema\tI-Disease\n,\tO\ntreated\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\ndiuretics\tO\n.\tO\n\nDue\tO\nto\tO\nsevere\tO\nsystolic\tB-Disease\ndysfunction\tI-Disease\nlosartan\tB-Chemical\nwas\tO\nprescribed\tO\n.\tO\n\nSurprisingly\tO\n,\tO\nthe\tO\nfirst\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\nof\tO\nlosartan\tB-Chemical\nresulted\tO\nin\tO\na\tO\nsudden\tO\nanuria\tB-Disease\n,\tO\nwhich\tO\nlasted\tO\neight\tO\nhours\tO\ndespite\tO\nhigh\tO\n-\tO\ndose\tO\nfurosemide\tB-Chemical\nand\tO\namine\tB-Chemical\ninfusion\tO\n.\tO\n\nOne\tO\nweek\tO\nlater\tO\n,\tO\nby\tO\nmistake\tO\n,\tO\nlosartan\tB-Chemical\nwas\tO\nprescribed\tO\nagain\tO\nand\tO\nafter\tO\nthe\tO\nsecond\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\n,\tO\nthe\tO\npatient\tO\ndeveloped\tO\na\tO\nsecond\tO\nepisode\tO\nof\tO\ntransient\tO\nanuria\tB-Disease\nlasting\tO\n10\tO\nhours\tO\n.\tO\n\nDuring\tO\nthese\tO\ntwo\tO\nepisodes\tO\n,\tO\nhis\tO\nblood\tO\npressure\tO\ndiminished\tO\nbut\tO\nno\tO\nsevere\tO\nhypotension\tB-Disease\nwas\tO\nnoted\tO\n.\tO\n\nUltimately\tO\n,\tO\nan\tO\narteriography\tO\nshowed\tO\na\tO\n70\tO\n-\tO\n80\tO\n%\tO\nrenal\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\n.\tO\n\nIn\tO\nthis\tO\npatient\tO\n,\tO\nrenal\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\ncombined\tO\nwith\tO\nheart\tB-Disease\nfailure\tI-Disease\nand\tO\ndiuretic\tO\ntherapy\tO\ncertainly\tO\nresulted\tO\nin\tO\na\tO\nstrong\tO\nactivation\tO\nof\tO\nthe\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\n(\tO\nRAS\tO\n)\tO\n.\tO\n\nUnder\tO\nsuch\tO\nconditions\tO\n,\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\nblockade\tO\nby\tO\nlosartan\tB-Chemical\nprobably\tO\ninduced\tO\na\tO\ncritical\tO\nfall\tO\nin\tO\nglomerular\tO\nfiltration\tO\npressure\tO\n.\tO\n\nThis\tO\ncase\tO\nreport\tO\nhighlights\tO\nthe\tO\nfact\tO\nthat\tO\nthe\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\nantagonist\tO\nlosartan\tB-Chemical\ncan\tO\ncause\tO\nserious\tO\nunexpected\tO\ncomplications\tO\nin\tO\npatients\tO\nwith\tO\nrenovascular\tB-Disease\ndisease\tI-Disease\nand\tO\nshould\tO\nbe\tO\nused\tO\nwith\tO\nextreme\tO\ncaution\tO\nin\tO\nthis\tO\nsetting\tO\n.\tO\n\nCalcineurin\tO\n-\tO\ninhibitor\tO\ninduced\tO\npain\tB-Disease\nsyndrome\tO\n(\tO\nCIPS\tB-Disease\n)\tO\n:\tO\na\tO\nsevere\tO\ndisabling\tO\ncomplication\tO\nafter\tO\norgan\tO\ntransplantation\tO\n.\tO\n\nBone\tO\npain\tB-Disease\nafter\tO\ntransplantation\tO\nis\tO\na\tO\nfrequent\tO\ncomplication\tO\nthat\tO\ncan\tO\nbe\tO\ncaused\tO\nby\tO\nseveral\tO\ndiseases\tO\n.\tO\n\nTreatment\tO\nstrategies\tO\ndepend\tO\non\tO\nthe\tO\ncorrect\tO\ndiagnosis\tO\nof\tO\nthe\tO\npain\tB-Disease\n.\tO\n\nNine\tO\npatients\tO\nwith\tO\nsevere\tO\npain\tB-Disease\nin\tO\ntheir\tO\nfeet\tO\n,\tO\nwhich\tO\nwas\tO\nregistered\tO\nafter\tO\ntransplantation\tO\n,\tO\nwere\tO\ninvestigated\tO\n.\tO\n\nMagnetic\tO\nresonance\tO\nimaging\tO\ndemonstrated\tO\nbone\tB-Disease\nmarrow\tI-Disease\noedema\tI-Disease\nin\tO\nthe\tO\npainful\tO\nbones\tO\n.\tO\n\nPain\tB-Disease\nwas\tO\nnot\tO\nexplained\tO\nby\tO\nother\tO\ndiseases\tO\ncausing\tO\nfoot\tO\npain\tB-Disease\n,\tO\nlike\tO\nreflex\tB-Disease\nsympathetic\tI-Disease\ndystrophy\tI-Disease\n,\tO\npolyneuropathy\tB-Disease\n,\tO\nMorton\tB-Disease\n'\tI-Disease\ns\tI-Disease\nneuralgia\tI-Disease\n,\tO\ngout\tB-Disease\n,\tO\nosteoporosis\tB-Disease\n,\tO\navascular\tB-Disease\nnecrosis\tI-Disease\n,\tO\nintermittent\tB-Disease\nclaudication\tI-Disease\n,\tO\northopaedic\tO\nfoot\tB-Disease\ndeformities\tI-Disease\n,\tO\nstress\tB-Disease\nfractures\tI-Disease\n,\tO\nand\tO\nhyperparathyroidism\tB-Disease\n.\tO\n\nThe\tO\nreduction\tO\nof\tO\ncyclosporine\tB-Chemical\n-\tO\nor\tO\ntacrolimus\tB-Chemical\ntrough\tO\nlevels\tO\nand\tO\nthe\tO\nadministration\tO\nof\tO\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\nled\tO\nto\tO\nrelief\tO\nof\tO\npain\tB-Disease\n.\tO\n\nThe\tO\nCalcineurin\tO\n-\tO\ninhibitor\tO\nInduced\tO\nPain\tB-Disease\nSyndrome\tO\n(\tO\nCIPS\tB-Disease\n)\tO\nis\tO\na\tO\nrare\tO\nbut\tO\nsevere\tO\nside\tO\neffect\tO\nof\tO\ncyclosporine\tB-Chemical\nor\tO\ntacrolimus\tB-Chemical\nand\tO\nis\tO\naccurately\tO\ndiagnosed\tO\nby\tO\nits\tO\ntypical\tO\npresentation\tO\n,\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nbone\tO\nscans\tO\n.\tO\n\nIncorrect\tO\ndiagnosis\tO\nof\tO\nthe\tO\nsyndrome\tO\nwill\tO\nlead\tO\nto\tO\na\tO\nsignificant\tO\nreduction\tO\nof\tO\nlife\tO\nquality\tO\nin\tO\npatients\tO\nsuffering\tO\nfrom\tO\nCIPS\tB-Disease\n.\tO\n\nBrain\tO\nnatriuretic\tO\npeptide\tO\nis\tO\na\tO\npredictor\tO\nof\tO\nanthracycline\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nAnthracyclines\tB-Chemical\nare\tO\neffective\tO\nantineoplastic\tO\ndrugs\tO\n,\tO\nbut\tO\nthey\tO\nfrequently\tO\ncause\tO\ndose\tO\n-\tO\nrelated\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nThe\tO\ncardiotoxicity\tB-Disease\nof\tO\nconventional\tO\nanthracycline\tB-Chemical\ntherapy\tO\nhighlights\tO\na\tO\nneed\tO\nto\tO\nsearch\tO\nfor\tO\nmethods\tO\nthat\tO\nare\tO\nhighly\tO\nsensitive\tO\nand\tO\ncapable\tO\nof\tO\npredicting\tO\ncardiac\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nWe\tO\nmeasured\tO\nthe\tO\nplasma\tO\nlevel\tO\nof\tO\nbrain\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nBNP\tO\n)\tO\nto\tO\ndetermine\tO\nwhether\tO\nBNP\tO\nmight\tO\nserve\tO\nas\tO\na\tO\nsimple\tO\ndiagnostic\tO\nindicator\tO\nof\tO\nanthracycline\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nin\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nleukemia\tI-Disease\ntreated\tO\nwith\tO\na\tO\ndaunorubicin\tB-Chemical\n(\tO\nDNR\tB-Chemical\n)\tO\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nThirteen\tO\npatients\tO\nwith\tO\nacute\tB-Disease\nleukemia\tI-Disease\nwere\tO\ntreated\tO\nwith\tO\na\tO\nDNR\tB-Chemical\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nThree\tO\npatients\tO\ndeveloped\tO\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\nafter\tO\nthe\tO\ncompletion\tO\nof\tO\nchemotherapy\tO\n.\tO\n\nFive\tO\npatients\tO\nwere\tO\ndiagnosed\tO\nas\tO\nhaving\tO\nsubclinical\tO\nheart\tB-Disease\nfailure\tI-Disease\nafter\tO\nthe\tO\ncompletion\tO\nof\tO\nchemotherapy\tO\n.\tO\n\nThe\tO\nplasma\tO\nlevels\tO\nof\tO\nBNP\tO\nin\tO\nall\tO\nthe\tO\npatients\tO\nwith\tO\nclinical\tO\nand\tO\nsubclinical\tO\nheart\tB-Disease\nfailure\tI-Disease\nincreased\tO\nabove\tO\nthe\tO\nnormal\tO\nlimit\tO\n(\tO\n40\tO\npg\tO\n/\tO\nml\tO\n)\tO\nbefore\tO\nthe\tO\ndetection\tO\nof\tO\nclinical\tO\nor\tO\nsubclinical\tO\nheart\tB-Disease\nfailure\tI-Disease\nby\tO\nradionuclide\tO\nangiography\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nBNP\tO\ndid\tO\nnot\tO\nincrease\tO\nin\tO\nthe\tO\npatients\tO\nwithout\tO\nheart\tB-Disease\nfailure\tI-Disease\ngiven\tO\nDNR\tB-Chemical\n,\tO\neven\tO\nat\tO\nmore\tO\nthan\tO\n700\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n.\tO\n\nThe\tO\nplasma\tO\nlevel\tO\nof\tO\nANP\tO\ndid\tO\nnot\tO\nalways\tO\nincrease\tO\nin\tO\nall\tO\nthe\tO\npatients\tO\nwith\tO\nclinical\tO\nand\tO\nsubclinical\tO\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nThese\tO\npreliminary\tO\nresults\tO\nsuggest\tO\nthat\tO\nBNP\tO\nmay\tO\nbe\tO\nuseful\tO\nas\tO\nan\tO\nearly\tO\nand\tO\nsensitive\tO\nindicator\tO\nof\tO\nanthracycline\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nNephrotoxicity\tB-Disease\nof\tO\ncombined\tO\ncephalothin\tB-Chemical\n-\tO\ngentamicin\tB-Chemical\nregimen\tO\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\nacute\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\n,\tO\ncharacterized\tO\nclinically\tO\nby\tO\nacute\tO\noliguric\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nwhile\tO\nthey\tO\nwere\tO\nreceiving\tO\na\tO\ncombination\tO\nof\tO\ncephalothin\tB-Chemical\nsodium\tI-Chemical\nand\tO\ngentamicin\tB-Chemical\nsulfate\tI-Chemical\ntherapy\tO\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\ngiven\tO\nthis\tO\ndrug\tO\nregimen\tO\nshould\tO\nbe\tO\nobserved\tO\nvery\tO\ncarefully\tO\nfor\tO\nearly\tO\nsigns\tO\nof\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nPatients\tO\nwith\tO\nrenal\tB-Disease\ninsufficiency\tI-Disease\nshould\tO\nnot\tO\nbe\tO\ngiven\tO\nthis\tO\nregimen\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tO\napoptotic\tO\nand\tO\nnecrotic\tB-Disease\ncell\tO\ndeaths\tO\nduring\tO\nacetaminophen\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n,\tO\namiodarone\tB-Chemical\n-\tO\ninduced\tO\nlung\tB-Disease\ntoxicity\tI-Disease\nand\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nby\tO\na\tO\nnovel\tO\nIH636\tB-Chemical\ngrape\tI-Chemical\nseed\tI-Chemical\nproanthocyanidin\tI-Chemical\nextract\tI-Chemical\n.\tO\n\nGrape\tB-Chemical\nseed\tI-Chemical\nextract\tI-Chemical\n,\tO\nprimarily\tO\na\tO\nmixture\tO\nof\tO\nproanthocyanidins\tB-Chemical\n,\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nmodulate\tO\na\tO\nwide\tO\n-\tO\nrange\tO\nof\tO\nbiological\tO\n,\tO\npharmacological\tO\nand\tO\ntoxicological\tO\neffects\tO\nwhich\tO\nare\tO\nmainly\tO\ncytoprotective\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tO\nof\tO\nIH636\tB-Chemical\ngrape\tI-Chemical\nseed\tI-Chemical\nproanthocyanidin\tI-Chemical\nextract\tI-Chemical\n(\tO\nGSPE\tB-Chemical\n)\tO\nto\tO\nprevent\tO\nacetaminophen\tB-Chemical\n(\tO\nAAP\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n,\tO\namiodarone\tB-Chemical\n(\tO\nAMI\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nlung\tB-Disease\ntoxicity\tI-Disease\n,\tO\nand\tO\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nExperimental\tO\ndesign\tO\nconsisted\tO\nof\tO\nfour\tO\ngroups\tO\n:\tO\ncontrol\tO\n(\tO\nvehicle\tO\nalone\tO\n)\tO\n,\tO\nGSPE\tB-Chemical\nalone\tO\n,\tO\ndrug\tO\nalone\tO\nand\tO\nGSPE\tB-Chemical\n+\tO\ndrug\tO\n.\tO\n\nFor\tO\nthe\tO\ncytoprotection\tO\nstudy\tO\n,\tO\nanimals\tO\nwere\tO\norally\tO\ngavaged\tO\n100\tO\nmg\tO\n/\tO\nKg\tO\nGSPE\tB-Chemical\nfor\tO\n7\tO\n-\tO\n10\tO\ndays\tO\nfollowed\tO\nby\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\nof\tO\norgan\tO\nspecific\tO\nthree\tO\ndrugs\tO\n(\tO\nAAP\tB-Chemical\n:\tO\n500\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n24\tO\nh\tO\n;\tO\nAMI\tB-Chemical\n:\tO\n50\tO\nmg\tO\n/\tO\nKg\tO\n/\tO\nday\tO\nfor\tO\nfour\tO\ndays\tO\n;\tO\nDOX\tB-Chemical\n:\tO\n20\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n48\tO\nh\tO\n)\tO\n.\tO\n\nResults\tO\nindicate\tO\nthat\tO\nGSPE\tB-Chemical\npreexposure\tO\nprior\tO\nto\tO\nAAP\tB-Chemical\n,\tO\nAMI\tB-Chemical\nand\tO\nDOX\tB-Chemical\n,\tO\nprovided\tO\nnear\tO\ncomplete\tO\nprotection\tO\nin\tO\nterms\tO\nof\tO\nserum\tO\nchemistry\tO\nchanges\tO\n(\tO\nALT\tO\n,\tO\nBUN\tO\nand\tO\nCPK\tO\n)\tO\n,\tO\nand\tO\nsignificantly\tO\nreduced\tO\nDNA\tO\nfragmentation\tO\n.\tO\n\nHistopathological\tO\nexamination\tO\nof\tO\nkidney\tO\n,\tO\nheart\tO\nand\tO\nlung\tO\nsections\tO\nrevealed\tO\nmoderate\tO\nto\tO\nmassive\tO\ntissue\tO\ndamage\tO\nwith\tO\na\tO\nvariety\tO\nof\tO\nmorphological\tO\naberrations\tO\nby\tO\nall\tO\nthe\tO\nthree\tO\ndrugs\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nGSPE\tB-Chemical\npreexposure\tO\nthan\tO\nin\tO\nits\tO\npresence\tO\n.\tO\n\nGSPE\tB-Chemical\n+\tO\ndrug\tO\nexposed\tO\ntissues\tO\nexhibited\tO\nminor\tO\nresidual\tO\ndamage\tO\nor\tO\nnear\tO\ntotal\tO\nrecovery\tO\n.\tO\n\nInterestingly\tO\n,\tO\nall\tO\nthe\tO\ndrugs\tO\n,\tO\nsuch\tO\nas\tO\n,\tO\nAAP\tB-Chemical\n,\tO\nAMI\tB-Chemical\nand\tO\nDOX\tB-Chemical\ninduced\tO\napoptotic\tO\ndeath\tO\nin\tO\naddition\tO\nto\tO\nnecrosis\tB-Disease\nin\tO\nthe\tO\nrespective\tO\norgans\tO\nwhich\tO\nwas\tO\nvery\tO\neffectively\tO\nblocked\tO\nby\tO\nGSPE\tB-Chemical\n.\tO\n\nSince\tO\nAAP\tB-Chemical\n,\tO\nAMI\tB-Chemical\nand\tO\nDOX\tB-Chemical\nundergo\tO\nbiotransformation\tO\nand\tO\nare\tO\nknown\tO\nto\tO\nproduce\tO\ndamaging\tO\nradicals\tO\nin\tO\nvivo\tO\n,\tO\nthe\tO\nprotection\tO\nby\tO\nGSPE\tB-Chemical\nmay\tO\nbe\tO\nlinked\tO\nto\tO\nboth\tO\ninhibition\tO\nof\tO\nmetabolism\tO\nand\tO\n/\tO\nor\tO\ndetoxification\tO\nof\tO\ncytotoxic\tO\nradicals\tO\n.\tO\n\nAdditionally\tO\n,\tO\nthis\tO\nmay\tO\nhave\tO\nbeen\tO\nthe\tO\nfirst\tO\nreport\tO\non\tO\nAMI\tB-Chemical\n-\tO\ninduced\tO\napoptotic\tO\ndeath\tO\nin\tO\nthe\tO\nlung\tO\ntissue\tO\n.\tO\n\nTaken\tO\ntogether\tO\n,\tO\nthese\tO\nevents\tO\nundoubtedly\tO\nestablish\tO\nGSPE\tB-Chemical\n'\tO\ns\tO\nabundant\tO\nbioavailability\tO\n,\tO\nand\tO\nthe\tO\npower\tO\nto\tO\ndefend\tO\nmultiple\tO\ntarget\tO\norgans\tO\nfrom\tO\ntoxic\tO\nassaults\tO\ninduced\tO\nby\tO\nstructurally\tO\ndiverse\tO\nand\tO\nfunctionally\tO\ndifferent\tO\nentities\tO\nin\tO\nvivo\tO\n.\tO\n\nAntidepressant\tB-Chemical\n-\tO\ninduced\tO\nmania\tB-Disease\nin\tO\nbipolar\tB-Disease\npatients\tO\n:\tO\nidentification\tO\nof\tO\nrisk\tO\nfactors\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nConcerns\tO\nabout\tO\npossible\tO\nrisks\tO\nof\tO\nswitching\tO\nto\tO\nmania\tB-Disease\nassociated\tO\nwith\tO\nantidepressants\tB-Chemical\ncontinue\tO\nto\tO\ninterfere\tO\nwith\tO\nthe\tO\nestablishment\tO\nof\tO\nan\tO\noptimal\tO\ntreatment\tO\nparadigm\tO\nfor\tO\nbipolar\tB-Disease\ndepression\tI-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nThe\tO\nresponse\tO\nof\tO\n44\tO\npatients\tO\nmeeting\tO\nDSM\tO\n-\tO\nIV\tO\ncriteria\tO\nfor\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\nto\tO\nnaturalistic\tO\ntreatment\tO\nwas\tO\nassessed\tO\nfor\tO\nat\tO\nleast\tO\n6\tO\nweeks\tO\nusing\tO\nthe\tO\nMontgomery\tO\n-\tO\nAsberg\tO\nDepression\tO\nRating\tO\nScale\tO\nand\tO\nthe\tO\nBech\tO\n-\tO\nRafaelson\tO\nMania\tO\nRating\tO\nScale\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tO\na\tO\nmanic\tB-Disease\nor\tO\nhypomanic\tB-Disease\nswitch\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tB-Disease\n-\tI-Disease\nIV\tI-Disease\nbipolar\tI-Disease\nI\tI-Disease\nvs\tO\n.\tO\nbipolar\tB-Disease\nII\tI-Disease\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tB-Disease\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tB-Chemical\ntherapy\tO\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tB-Chemical\ndrugs\tO\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\n[\tO\nSSRIs\tB-Chemical\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tB-Chemical\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tO\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSwitches\tO\nto\tO\nhypomania\tB-Disease\nor\tO\nmania\tB-Disease\noccurred\tO\nin\tO\n27\tO\n%\tO\nof\tO\nall\tO\npatients\tO\n(\tO\nN\tO\n=\tO\n12\tO\n)\tO\n(\tO\nand\tO\nin\tO\n24\tO\n%\tO\nof\tO\nthe\tO\nsubgroup\tO\nof\tO\npatients\tO\ntreated\tO\nwith\tO\nSSRIs\tB-Chemical\n[\tO\n8\tO\n/\tO\n33\tO\n]\tO\n)\tO\n;\tO\n16\tO\n%\tO\n(\tO\nN\tO\n=\tO\n7\tO\n)\tO\nexperienced\tO\nmanic\tB-Disease\nepisodes\tO\n,\tO\nand\tO\n11\tO\n%\tO\n(\tO\nN\tO\n=\tO\n5\tO\n)\tO\nexperienced\tO\nhypomanic\tB-Disease\nepisodes\tO\n.\tO\n\nSex\tO\n,\tO\nage\tO\n,\tO\ndiagnosis\tO\n(\tO\nbipolar\tB-Disease\nI\tI-Disease\nvs\tO\n.\tO\nbipolar\tB-Disease\nII\tI-Disease\n)\tO\n,\tO\nand\tO\nadditional\tO\ntreatment\tO\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nrisk\tO\nof\tO\nswitching\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nmood\tO\nswitches\tO\nwere\tO\nless\tO\nfrequent\tO\nin\tO\npatients\tO\nreceiving\tO\nlithium\tB-Chemical\n(\tO\n15\tO\n%\tO\n,\tO\n4\tO\n/\tO\n26\tO\n)\tO\nthan\tO\nin\tO\npatients\tO\nnot\tO\ntreated\tO\nwith\tO\nlithium\tB-Chemical\n(\tO\n44\tO\n%\tO\n,\tO\n8\tO\n/\tO\n18\tO\n;\tO\np\tO\n=\tO\n.\tO\n04\tO\n)\tO\n.\tO\n\nThe\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tB-Disease\nepisodes\tO\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nprobability\tO\nof\tO\nswitching\tO\n,\tO\nwhereas\tO\na\tO\nhigh\tO\nscore\tO\non\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemistructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\ngreater\tO\nrisk\tO\nof\tO\nswitching\tO\n(\tO\np\tO\n=\tO\n.\tO\n008\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nfrequency\tO\nof\tO\nmood\tO\nswitching\tO\nassociated\tO\nwith\tO\nacute\tO\nantidepressant\tB-Chemical\ntherapy\tO\nmay\tO\nbe\tO\nreduced\tO\nby\tO\nlithium\tB-Chemical\ntreatment\tO\n.\tO\n\nPeritubular\tO\ncapillary\tO\nbasement\tO\nmembrane\tO\nreduplication\tO\nin\tO\nallografts\tO\nand\tO\nnative\tO\nkidney\tB-Disease\ndisease\tI-Disease\n:\tO\na\tO\nclinicopathologic\tO\nstudy\tO\nof\tO\n278\tO\nconsecutive\tO\nrenal\tO\nspecimens\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAn\tO\nassociation\tO\nhas\tO\nbeen\tO\nfound\tO\nbetween\tO\ntransplant\tB-Disease\nglomerulopathy\tI-Disease\n(\tO\nTG\tB-Disease\n)\tO\nand\tO\nreduplication\tO\nof\tO\nperitubular\tO\ncapillary\tO\nbasement\tO\nmembranes\tO\n(\tO\nPTCR\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nrenal\tO\nallografts\tO\nwith\tO\nTG\tB-Disease\n,\tO\nwe\tO\nalso\tO\nexamined\tO\ngrafts\tO\nwith\tO\nacute\tO\nrejection\tO\n,\tO\nrecurrent\tO\nglomerulonephritis\tB-Disease\n,\tO\nchronic\tB-Disease\nallograft\tI-Disease\nnephropathy\tI-Disease\nand\tO\nstable\tO\ngrafts\tO\n(\tO\n\"\tO\nprotocol\tO\nbiopsies\tO\n\"\tO\n)\tO\n.\tO\n\nNative\tO\nkidney\tO\nspecimens\tO\nincluded\tO\na\tO\nwide\tO\nrange\tO\nof\tO\nglomerulopathies\tB-Disease\nas\tO\nwell\tO\nas\tO\ncases\tO\nof\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n,\tO\nmalignant\tB-Disease\nhypertension\tI-Disease\n,\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\n,\tO\nand\tO\nacute\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nfound\tO\nPTCR\tO\nin\tO\n14\tO\nof\tO\n15\tO\ncases\tO\nof\tO\nTG\tB-Disease\n,\tO\nin\tO\n7\tO\ntransplant\tO\nbiopsy\tO\nspecimens\tO\nwithout\tO\nTG\tB-Disease\n,\tO\nand\tO\nin\tO\n13\tO\nof\tO\n143\tO\nnative\tO\nkidney\tO\nbiopsy\tO\nspecimens\tO\n.\tO\n\nThese\tO\n13\tO\nincluded\tO\ncases\tO\nof\tO\nmalignant\tB-Disease\nhypertension\tI-Disease\n,\tO\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n,\tO\nlupus\tB-Disease\nnephritis\tI-Disease\n,\tO\nHenoch\tO\n-\tO\nSchonlein\tO\nnephritis\tO\n,\tO\ncrescentic\tO\nglomerulonephritis\tB-Disease\n,\tO\nand\tO\ncocaine\tB-Chemical\n-\tO\nrelated\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nMild\tO\nPTCR\tO\nin\tO\nallografts\tO\nwithout\tO\nTG\tB-Disease\ndid\tO\nnot\tO\npredict\tO\nrenal\tB-Disease\nfailure\tI-Disease\nor\tO\nsignificant\tO\nproteinuria\tB-Disease\nafter\tO\nfollow\tO\n-\tO\nup\tO\nperiods\tO\nof\tO\nbetween\tO\n3\tO\nmonths\tO\nand\tO\n1\tO\nyear\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nconclude\tO\nthat\tO\nin\tO\ntransplants\tO\n,\tO\nthere\tO\nis\tO\na\tO\nstrong\tO\nassociation\tO\nbetween\tO\nwell\tO\n-\tO\ndeveloped\tO\nPTCR\tO\nand\tO\nTG\tB-Disease\n,\tO\nwhile\tO\nthe\tO\nsignificance\tO\nof\tO\nmild\tO\nPTCR\tO\nand\tO\nits\tO\npredictive\tO\nvalue\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nTG\tB-Disease\nis\tO\nunclear\tO\n.\tO\n\nPTCR\tO\nalso\tO\noccurs\tO\nin\tO\ncertain\tO\nnative\tO\nkidney\tB-Disease\ndiseases\tI-Disease\n,\tO\nthough\tO\nthe\tO\nassociation\tO\nis\tO\nnot\tO\nas\tO\nstrong\tO\nas\tO\nthat\tO\nfor\tO\nTG\tB-Disease\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\nrepeated\tO\nendothelial\tB-Disease\ninjury\tI-Disease\n,\tO\nincluding\tO\nimmunologic\tB-Disease\ninjury\tI-Disease\n,\tO\nmay\tO\nbe\tO\nthe\tO\ncause\tO\nof\tO\nthis\tO\nlesion\tO\nboth\tO\nin\tO\nallografts\tO\nand\tO\nnative\tO\nkidneys\tO\n.\tO\n\nCaffeine\tB-Chemical\n-\tO\ninduced\tO\ncardiac\tB-Disease\narrhythmia\tI-Disease\n:\tO\nan\tO\nunrecognised\tO\ndanger\tO\nof\tO\nhealthfood\tO\nproducts\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\npre\tO\n-\tO\nexisting\tO\nmitral\tB-Disease\nvalve\tI-Disease\nprolapse\tI-Disease\nwho\tO\ndeveloped\tO\nintractable\tO\nventricular\tB-Disease\nfibrillation\tI-Disease\nafter\tO\nconsuming\tO\na\tO\n\"\tO\nnatural\tO\nenergy\tO\n\"\tO\nguarana\tO\nhealth\tO\ndrink\tO\ncontaining\tO\na\tO\nhigh\tO\nconcentration\tO\nof\tO\ncaffeine\tB-Chemical\n.\tO\n\nConformationally\tO\nrestricted\tO\nanalogs\tO\nof\tO\nBD1008\tB-Chemical\nand\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tB-Chemical\ntargeting\tO\nsigma1\tO\nreceptors\tO\nproduce\tO\nanti\tO\n-\tO\ncocaine\tB-Chemical\neffects\tO\nin\tO\nmice\tO\n.\tO\n\nCocaine\tB-Chemical\n'\tO\ns\tO\nability\tO\nto\tO\ninteract\tO\nwith\tO\nsigma\tO\nreceptors\tO\nsuggests\tO\nthat\tO\nthese\tO\nproteins\tO\nmediate\tO\nsome\tO\nof\tO\nits\tO\nbehavioral\tO\neffects\tO\n.\tO\n\nTherefore\tO\n,\tO\nthree\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nligands\tO\nwith\tO\nantagonist\tO\nactivity\tO\nwere\tO\nevaluated\tO\nin\tO\nSwiss\tO\nWebster\tO\nmice\tO\n:\tO\nBD1018\tB-Chemical\n(\tO\n3S\tB-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichlorophenyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndiazabicyclo\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n.\tI-Chemical\n3\tI-Chemical\n.\tI-Chemical\n0\tI-Chemical\n]\tI-Chemical\nnonane\tI-Chemical\n)\tO\n,\tO\nBD1063\tB-Chemical\n(\tO\n1\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichlorophenyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethylpiperazine\tI-Chemical\n)\tO\n,\tO\nand\tO\nLR132\tB-Chemical\n(\tO\n1R\tO\n,\tO\n2S\tO\n-\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncis\tO\n-\tO\nN\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n2\tO\n-\tO\n(\tO\n1\tO\n-\tO\npyrrolidinyl\tO\n)\tO\ncyclohexylamine\tO\n)\tO\n.\tO\n\nThe\tO\nthree\tO\ncompounds\tO\nvary\tO\nin\tO\ntheir\tO\naffinities\tO\nfor\tO\nsigma2\tO\nreceptors\tO\nand\tO\nexhibit\tO\nnegligible\tO\naffinities\tO\nfor\tO\ndopamine\tB-Chemical\n,\tO\nopioid\tO\n,\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nand\tO\nNMDA\tB-Chemical\nreceptors\tO\n.\tO\n\nIn\tO\nbehavioral\tO\nstudies\tO\n,\tO\npre\tO\n-\tO\ntreatment\tO\nof\tO\nmice\tO\nwith\tO\nBD1018\tB-Chemical\n,\tO\nBD1063\tB-Chemical\n,\tO\nor\tO\nLR132\tB-Chemical\nsignificantly\tO\nattenuated\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nconvulsions\tB-Disease\nand\tO\nlethality\tO\n.\tO\n\nMoreover\tO\n,\tO\npost\tO\n-\tO\ntreatment\tO\nwith\tO\nLR132\tB-Chemical\nprevented\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nlethality\tO\nin\tO\na\tO\nsignificant\tO\nproportion\tO\nof\tO\nanimals\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\nthe\tO\nprotection\tO\nprovided\tO\nby\tO\nthe\tO\nputative\tO\nantagonists\tO\n,\tO\nthe\tO\nwell\tO\n-\tO\ncharacterized\tO\nsigma\tO\nreceptor\tO\nagonist\tO\ndi\tB-Chemical\n-\tI-Chemical\no\tI-Chemical\n-\tI-Chemical\ntolylguanidine\tI-Chemical\n(\tO\nDTG\tB-Chemical\n)\tO\nand\tO\nthe\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nagonist\tO\nBD1031\tB-Chemical\n(\tO\n3R\tB-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichlorophenyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndiazabicyclo\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n.\tI-Chemical\n3\tI-Chemical\n.\tI-Chemical\n0\tI-Chemical\n]\tI-Chemical\nnonane\tI-Chemical\n)\tO\neach\tO\nworsened\tO\nthe\tO\nbehavioral\tO\ntoxicity\tB-Disease\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nAt\tO\ndoses\tO\nwhere\tO\nalone\tO\n,\tO\nthey\tO\nproduced\tO\nno\tO\nsignificant\tO\neffects\tO\non\tO\nlocomotion\tO\n,\tO\nBD1018\tB-Chemical\n,\tO\nBD1063\tB-Chemical\nand\tO\nLR132\tB-Chemical\nsignificantly\tO\nattenuated\tO\nthe\tO\nlocomotor\tO\nstimulatory\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nTo\tO\nfurther\tO\nvalidate\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\nanti\tO\n-\tO\ncocaine\tB-Chemical\neffects\tO\nof\tO\nthe\tO\nnovel\tO\nligands\tO\ninvolved\tO\nantagonism\tO\nof\tO\nsigma\tO\nreceptors\tO\n,\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tB-Chemical\nagainst\tO\nsigma1\tO\nreceptors\tO\nwas\tO\nalso\tO\nshown\tO\nto\tO\nsignificantly\tO\nattenuate\tO\nthe\tO\nconvulsive\tB-Disease\nand\tO\nlocomotor\tO\nstimulatory\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\n.\tO\n\nTogether\tO\n,\tO\nthe\tO\ndata\tO\nsuggests\tO\nthat\tO\nfunctional\tO\nantagonism\tO\nof\tO\nsigma\tO\nreceptors\tO\nis\tO\ncapable\tO\nof\tO\nattenuating\tO\na\tO\nnumber\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nbehaviors\tO\n.\tO\n\nRanitidine\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nin\tO\na\tO\ncadaveric\tO\nrenal\tO\nallograft\tO\n.\tO\n\nRanitidine\tB-Chemical\nfrequently\tO\nis\tO\nused\tO\nfor\tO\npreventing\tO\npeptic\tO\nulceration\tO\nafter\tO\nrenal\tO\ntransplantation\tO\n.\tO\n\nThis\tO\ndrug\tO\noccasionally\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nin\tO\nnative\tO\nkidneys\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nranitidine\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nin\tO\na\tO\nrecipient\tO\nof\tO\na\tO\ncadaveric\tO\nrenal\tO\nallograft\tO\npresenting\tO\nwith\tO\nacute\tO\nallograft\tO\ndysfunction\tO\nwithin\tO\n48\tO\nhours\tO\nof\tO\nexposure\tO\nto\tO\nthe\tO\ndrug\tO\n.\tO\n\nLiver\tB-Disease\ndisease\tI-Disease\ncaused\tO\nby\tO\npropylthiouracil\tB-Chemical\n.\tO\n\nThis\tO\nreport\tO\npresents\tO\nthe\tO\nclinical\tO\n,\tO\nlaboratory\tO\n,\tO\nand\tO\nlight\tO\nand\tO\nelectron\tO\nmicroscopic\tO\nobservations\tO\non\tO\na\tO\npatient\tO\nwith\tO\nchronic\tB-Disease\nactive\tI-Disease\n(\tI-Disease\naggressive\tI-Disease\n)\tI-Disease\nhepatitis\tI-Disease\ncaused\tO\nby\tO\nthe\tO\nadministration\tO\nof\tO\npropylthiouracil\tB-Chemical\n.\tO\n\nThis\tO\nis\tO\nan\tO\naddition\tO\nto\tO\nthe\tO\nlist\tO\nof\tO\ndrugs\tO\nthat\tO\nmust\tO\nbe\tO\nconsidered\tO\nin\tO\nthe\tO\nevaluation\tO\nof\tO\nchronic\tO\nliver\tB-Disease\ndisease\tI-Disease\n.\tO\n\nWithdrawal\tB-Disease\n-\tI-Disease\nemergent\tI-Disease\nrabbit\tI-Disease\nsyndrome\tI-Disease\nduring\tO\ndose\tO\nreduction\tO\nof\tO\nrisperidone\tB-Chemical\n.\tO\n\nRabbit\tB-Disease\nsyndrome\tI-Disease\n(\tO\nRS\tB-Disease\n)\tO\nis\tO\na\tO\nrare\tO\nextrapyramidal\tO\nside\tO\neffect\tO\ncaused\tO\nby\tO\nprolonged\tO\nneuroleptic\tO\nmedication\tO\n.\tO\n\nHere\tO\nwe\tO\npresent\tO\na\tO\ncase\tO\nof\tO\nwithdrawal\tB-Disease\n-\tI-Disease\nemergent\tI-Disease\nRS\tI-Disease\n,\tO\nwhich\tO\nis\tO\nthe\tO\nfirst\tO\nof\tO\nits\tO\nkind\tO\nto\tO\nbe\tO\nreported\tO\n.\tO\n\nThe\tO\npatient\tO\ndeveloped\tO\nRS\tB-Disease\nduring\tO\ndose\tO\nreduction\tO\nof\tO\nrisperidone\tB-Chemical\n.\tO\n\nThe\tO\nsymptom\tO\nwas\tO\ntreated\tO\nsuccessfully\tO\nwith\tO\ntrihexyphenidyl\tB-Chemical\nanticholinergic\tO\ntherapy\tO\n.\tO\n\nThe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nwithdrawal\tB-Disease\n-\tI-Disease\nemergent\tI-Disease\nRS\tI-Disease\nin\tO\nthe\tO\npresent\tO\ncase\tO\nmay\tO\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nthe\tO\npharmacological\tO\nprofile\tO\nof\tO\nrisperidone\tB-Chemical\n,\tO\na\tO\nserotonin\tO\n-\tO\ndopamine\tB-Chemical\nantagonist\tO\n,\tO\nsuggesting\tO\nthe\tO\npathophysiologic\tO\ninfluence\tO\nof\tO\nthe\tO\nserotonin\tB-Chemical\nsystem\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nRS\tB-Disease\n.\tO\n\nPharmacokinetic\tO\n/\tO\npharmacodynamic\tO\nassessment\tO\nof\tO\nthe\tO\neffects\tO\nof\tO\nE4031\tB-Chemical\n,\tO\ncisapride\tB-Chemical\n,\tO\nterfenadine\tB-Chemical\nand\tO\nterodiline\tB-Chemical\non\tO\nmonophasic\tO\naction\tO\npotential\tO\nduration\tO\nin\tO\ndog\tO\n.\tO\n\nTorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\nTDP\tB-Disease\n)\tO\nis\tO\na\tO\npotentially\tO\nfatal\tO\nventricular\tO\ntachycardia\tO\nassociated\tO\nwith\tO\nincreases\tO\nin\tO\nQT\tO\ninterval\tO\nand\tO\nmonophasic\tO\naction\tO\npotential\tO\nduration\tO\n(\tO\nMAPD\tO\n)\tO\n.\tO\n\nTDP\tB-Disease\nis\tO\na\tO\nside\tO\n-\tO\neffect\tO\nthat\tO\nhas\tO\nled\tO\nto\tO\nwithdrawal\tO\nof\tO\nseveral\tO\ndrugs\tO\nfrom\tO\nthe\tO\nmarket\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\nterfenadine\tB-Chemical\nand\tO\nterodiline\tB-Chemical\n)\tO\n.\tO\n\nThe\tO\npotential\tO\nof\tO\ncompounds\tO\nto\tO\ncause\tO\nTDP\tB-Disease\nwas\tO\nevaluated\tO\nby\tO\nmonitoring\tO\ntheir\tO\neffects\tO\non\tO\nMAPD\tO\nin\tO\ndog\tO\n.\tO\n\nFour\tO\ncompounds\tO\nknown\tO\nto\tO\nincrease\tO\nQT\tO\ninterval\tO\nand\tO\ncause\tO\nTDP\tB-Disease\nwere\tO\ninvestigated\tO\n:\tO\nterfenadine\tB-Chemical\n,\tO\nterodiline\tB-Chemical\n,\tO\ncisapride\tB-Chemical\nand\tO\nE4031\tB-Chemical\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nthe\tO\nfree\tO\nED50\tO\nin\tO\nplasma\tO\nfor\tO\nterfenadine\tB-Chemical\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\n,\tO\nterodiline\tB-Chemical\n(\tO\n76\tO\nnM\tO\n)\tO\n,\tO\ncisapride\tB-Chemical\n(\tO\n11\tO\nnM\tO\n)\tO\nand\tO\nE4031\tB-Chemical\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\nclosely\tO\ncorrelate\tO\nwith\tO\nthe\tO\nfree\tO\nconcentration\tO\nin\tO\nman\tO\ncausing\tO\nQT\tO\neffects\tO\n.\tO\n\nFor\tO\ncompounds\tO\nthat\tO\nhave\tO\nshown\tO\nTDP\tB-Disease\nin\tO\nthe\tO\nclinic\tO\n(\tO\nterfenadine\tB-Chemical\n,\tO\nterodiline\tB-Chemical\n,\tO\ncisapride\tB-Chemical\n)\tO\nthere\tO\nis\tO\nlittle\tO\ndifferentiation\tO\nbetween\tO\nthe\tO\ndog\tO\nED50\tO\nand\tO\nthe\tO\nefficacious\tO\nfree\tO\nplasma\tO\nconcentrations\tO\nin\tO\nman\tO\n(\tO\n<\tO\n10\tO\n-\tO\nfold\tO\n)\tO\nreflecting\tO\ntheir\tO\nlimited\tO\nsafety\tO\nmargins\tO\n.\tO\n\nThese\tO\ndata\tO\nunderline\tO\nthe\tO\nneed\tO\nto\tO\nmaximize\tO\nthe\tO\ntherapeutic\tO\nratio\tO\nwith\tO\nrespect\tO\nto\tO\nTDP\tB-Disease\nin\tO\npotential\tO\ndevelopment\tO\ncandidates\tO\nand\tO\nthe\tO\nimportance\tO\nof\tO\nusing\tO\nfree\tO\ndrug\tO\nconcentrations\tO\nin\tO\npharmacokinetic\tO\n/\tO\npharmacodynamic\tO\nstudies\tO\n.\tO\n\nBladder\tO\nretention\tB-Disease\nof\tI-Disease\nurine\tI-Disease\nas\tO\na\tO\nresult\tO\nof\tO\ncontinuous\tO\nintravenous\tO\ninfusion\tO\nof\tO\nfentanyl\tB-Chemical\n:\tO\n2\tO\ncase\tO\nreports\tO\n.\tO\n\nSedation\tO\nhas\tO\nbeen\tO\ncommonly\tO\nused\tO\nin\tO\nthe\tO\nneonate\tO\nto\tO\ndecrease\tO\nthe\tO\nstress\tO\nand\tO\npain\tB-Disease\nfrom\tO\nthe\tO\nnoxious\tO\nstimuli\tO\nand\tO\ninvasive\tO\nprocedures\tO\nin\tO\nthe\tO\nneonatal\tO\nintensive\tO\ncare\tO\nunit\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nto\tO\nfacilitate\tO\nsynchrony\tO\nbetween\tO\nventilator\tO\nand\tO\nspontaneous\tO\nbreaths\tO\n.\tO\n\nFentanyl\tB-Chemical\n,\tO\nan\tO\nopioid\tO\nanalgesic\tO\n,\tO\nis\tO\nfrequently\tO\nused\tO\nin\tO\nthe\tO\nneonatal\tO\nintensive\tO\ncare\tO\nunit\tO\nsetting\tO\nfor\tO\nthese\tO\nvery\tO\npurposes\tO\n.\tO\n\nVarious\tO\nreported\tO\nside\tO\neffects\tO\nof\tO\nfentanyl\tB-Chemical\nadministration\tO\ninclude\tO\nchest\tB-Disease\nwall\tI-Disease\nrigidity\tI-Disease\n,\tO\nhypotension\tB-Disease\n,\tO\nrespiratory\tB-Disease\ndepression\tI-Disease\n,\tO\nand\tO\nbradycardia\tB-Disease\n.\tO\n\nHere\tO\n,\tO\n2\tO\ncases\tO\nof\tO\nurinary\tB-Disease\nbladder\tI-Disease\nretention\tI-Disease\nleading\tO\nto\tO\nrenal\tO\npelvocalyceal\tO\ndilatation\tO\nmimicking\tO\nhydronephrosis\tB-Disease\nas\tO\na\tO\nresult\tO\nof\tO\ncontinuous\tO\ninfusion\tO\nof\tO\nfentanyl\tB-Chemical\nare\tO\nreported\tO\n.\tO\n\nFatal\tO\nmyeloencephalopathy\tB-Disease\ndue\tO\nto\tO\naccidental\tO\nintrathecal\tO\nvincristin\tB-Chemical\nadministration\tO\n:\tO\na\tO\nreport\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nWe\tO\nreport\tO\non\tO\ntwo\tO\nfatal\tO\ncases\tO\nof\tO\naccidental\tO\nintrathecal\tO\nvincristine\tB-Chemical\ninstillation\tO\nin\tO\na\tO\n5\tO\n-\tO\nyear\tO\nold\tO\ngirl\tO\nwith\tO\nrecurrent\tO\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleucemia\tI-Disease\nand\tO\na\tO\n57\tO\n-\tO\nyear\tO\nold\tO\nman\tO\nwith\tO\nlymphoblastic\tB-Disease\nlymphoma\tI-Disease\n.\tO\n\nThe\tO\ngirl\tO\ndied\tO\nseven\tO\ndays\tO\n,\tO\nthe\tO\nman\tO\nfour\tO\nweeks\tO\nafter\tO\nintrathecal\tO\ninjection\tO\nof\tO\nvincristine\tB-Chemical\n.\tO\n\nClinically\tO\n,\tO\nthe\tO\nonset\tO\nwas\tO\ncharacterized\tO\nby\tO\nthe\tO\nsigns\tO\nof\tO\nopistothonus\tB-Disease\n,\tI-Disease\nsensory\tI-Disease\nand\tI-Disease\nmotor\tI-Disease\ndysfunction\tI-Disease\nand\tO\nascending\tO\nparalysis\tB-Disease\n.\tO\n\nHistological\tO\nand\tO\nimmunohistochemical\tO\ninvestigations\tO\n(\tO\nHE\tO\n-\tO\nLFB\tO\n,\tO\nCD\tO\n-\tO\n68\tO\n,\tO\nNeurofilament\tO\n)\tO\nrevealed\tO\ndegeneration\tB-Disease\nof\tI-Disease\nmyelin\tI-Disease\nand\tI-Disease\naxons\tI-Disease\nas\tO\nwell\tO\nas\tO\npseudocystic\tB-Disease\ntransformation\tI-Disease\nin\tO\nareas\tO\nexposed\tO\nto\tO\nvincristine\tB-Chemical\n,\tO\naccompanied\tO\nby\tO\nsecondary\tO\nchanges\tO\nwith\tO\nnumerous\tO\nprominent\tO\nmacrophages\tO\n.\tO\n\nA\tO\nbetter\tO\ncontrolled\tO\nregimen\tO\nfor\tO\nadministering\tO\nvincristine\tB-Chemical\nand\tO\nintrathecal\tO\nchemotherapy\tO\nis\tO\nrecommended\tO\n.\tO\n\nPalpebral\tO\ntwitching\tO\nin\tO\na\tO\ndepressed\tB-Disease\nadolescent\tO\non\tO\ncitalopram\tB-Chemical\n.\tO\n\nCurrent\tO\nestimates\tO\nsuggest\tO\nthat\tO\nbetween\tO\n0\tO\n.\tO\n4\tO\n%\tO\nand\tO\n8\tO\n.\tO\n3\tO\n%\tO\nof\tO\nchildren\tO\nand\tO\nadolescents\tO\nare\tO\naffected\tO\nby\tO\nmajor\tB-Disease\ndepression\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\nfavorable\tO\nresponse\tO\nto\tO\ntreatment\tO\nwith\tO\ncitalopram\tB-Chemical\nby\tO\na\tO\n15\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwith\tO\nmajor\tB-Disease\ndepression\tI-Disease\nwho\tO\nexhibited\tO\npalpebral\tB-Disease\ntwitching\tI-Disease\nduring\tO\nhis\tO\nfirst\tO\n2\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nThis\tO\nmay\tO\nhave\tO\nbeen\tO\na\tO\nside\tO\neffect\tO\nof\tO\ncitalopram\tB-Chemical\nas\tO\nit\tO\nremitted\tO\nwith\tO\nredistribution\tO\nof\tO\ndoses\tO\n.\tO\n\nThe\tO\n3\tO\n-\tO\nweek\tO\nsulphasalazine\tB-Chemical\nsyndrome\tO\nstrikes\tO\nagain\tO\n.\tO\n\nA\tO\n34\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nlady\tO\ndeveloped\tO\na\tO\nconstellation\tO\nof\tO\ndermatitis\tB-Disease\n,\tO\nfever\tB-Disease\n,\tO\nlymphadenopathy\tB-Disease\nand\tO\nhepatitis\tO\n,\tO\nbeginning\tO\non\tO\nthe\tO\n17th\tO\nday\tO\nof\tO\na\tO\ncourse\tO\nof\tO\noral\tO\nsulphasalazine\tB-Chemical\nfor\tO\nsero\tO\n-\tO\nnegative\tO\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nCervical\tO\nand\tO\ninguinal\tO\nlymph\tO\nnode\tO\nbiopsies\tO\nshowed\tO\nthe\tO\nfeatures\tO\nof\tO\nsevere\tO\nnecrotising\tO\nlymphadenitis\tB-Disease\n,\tO\nassociated\tO\nwith\tO\nerythrophagocytosis\tO\nand\tO\nprominent\tO\neosinophilic\tO\ninfiltrates\tO\n,\tO\nwithout\tO\nviral\tO\ninclusion\tO\nbodies\tO\n,\tO\nsuggestive\tO\nof\tO\nan\tO\nadverse\tB-Disease\ndrug\tI-Disease\nreaction\tI-Disease\n.\tO\nA\tO\nweek\tO\nlater\tO\n,\tO\nfulminant\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nhepatitis\tI-Disease\n,\tO\nassociated\tO\nwith\tO\nthe\tO\npresence\tO\nof\tO\nanti\tO\n-\tO\nnuclear\tO\nautoantibodies\tO\n(\tO\nbut\tO\nnot\tO\nwith\tO\nother\tO\nmarkers\tO\nof\tO\nautoimmunity\tB-Disease\n)\tO\n,\tO\nand\tO\naccompanied\tO\nby\tO\nmulti\tB-Disease\n-\tI-Disease\norgan\tI-Disease\nfailure\tI-Disease\nand\tO\nsepsis\tB-Disease\n,\tO\nsupervened\tO\n.\tO\n\nShe\tO\nsubsequently\tO\ndied\tO\nsome\tO\n5\tO\nweeks\tO\nafter\tO\nthe\tO\ncommencement\tO\nof\tO\nher\tO\ndrug\tO\ntherapy\tO\n.\tO\nPost\tO\n-\tO\nmortem\tO\nexamination\tO\nshowed\tO\nevidence\tO\nof\tO\nmassive\tB-Disease\nhepatocellular\tI-Disease\nnecrosis\tI-Disease\n,\tO\nacute\tO\nhypersensitivity\tO\nmyocarditis\tO\n,\tO\nfocal\tO\nacute\tO\ntubulo\tO\n-\tO\ninterstitial\tO\nnephritis\tB-Disease\nand\tO\nextensive\tO\nbone\tB-Disease\nmarrow\tI-Disease\nnecrosis\tI-Disease\n,\tO\nwith\tO\nno\tO\nevidence\tO\nof\tO\nmalignancy\tB-Disease\n.\tO\n\nIt\tO\nis\tO\nthought\tO\nthat\tO\nthe\tO\nclinico\tO\n-\tO\npathological\tO\nfeatures\tO\nand\tO\nchronology\tO\nof\tO\nthis\tO\ncase\tO\nbore\tO\nthe\tO\nhallmarks\tO\nof\tO\nthe\tO\nso\tO\n-\tO\ncalled\tO\n\"\tO\n3\tO\n-\tO\nweek\tO\nsulphasalazine\tB-Chemical\nsyndrome\tO\n\"\tO\n,\tO\na\tO\nrare\tO\n,\tO\nbut\tO\noften\tO\nfatal\tO\n,\tO\nimmunoallergic\tO\nreaction\tO\nto\tO\nsulphasalazine\tB-Chemical\n.\tO\n\nIntravenous\tO\nadministration\tO\nof\tO\nprochlorperazine\tB-Chemical\nby\tO\n15\tO\n-\tO\nminute\tO\ninfusion\tO\nversus\tO\n2\tO\n-\tO\nminute\tO\nbolus\tO\ndoes\tO\nnot\tO\naffect\tO\nthe\tO\nincidence\tO\nof\tO\nakathisia\tB-Disease\n:\tO\na\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ncontrolled\tO\ntrial\tO\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nWe\tO\nsought\tO\nto\tO\ncompare\tO\nthe\tO\nrate\tO\nof\tO\nakathisia\tB-Disease\nafter\tO\nadministration\tO\nof\tO\nintravenous\tO\nprochlorperazine\tB-Chemical\nas\tO\na\tO\n2\tO\n-\tO\nminute\tO\nbolus\tO\nor\tO\n15\tO\n-\tO\nminute\tO\ninfusion\tO\n.\tO\n\nPatients\tO\naged\tO\n18\tO\nyears\tO\nor\tO\nolder\tO\ntreated\tO\nwith\tO\nprochlorperazine\tO\nfor\tO\nheadache\tB-Disease\n,\tO\nnausea\tB-Disease\n,\tO\nor\tO\nvomiting\tB-Disease\nwere\tO\neligible\tO\nfor\tO\ninclusion\tO\n.\tO\n\nStudy\tO\nparticipants\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tO\nmg\tO\nof\tO\nprochlorperazine\tB-Chemical\nadministered\tO\nintravenously\tO\nby\tO\nmeans\tO\nof\tO\n2\tO\n-\tO\nminute\tO\npush\tO\n(\tO\nbolus\tO\ngroup\tO\n)\tO\nor\tO\n10\tO\nmg\tO\ndiluted\tO\nin\tO\n50\tO\nmL\tO\nof\tO\nnormal\tO\nsaline\tO\nsolution\tO\nadministered\tO\nby\tO\nmeans\tO\nof\tO\nintravenous\tO\ninfusion\tO\nduring\tO\na\tO\n15\tO\n-\tO\nminute\tO\nperiod\tO\n(\tO\ninfusion\tO\ngroup\tO\n)\tO\n.\tO\n\nThe\tO\nmain\tO\noutcome\tO\nwas\tO\nthe\tO\nnumber\tO\nof\tO\nstudy\tO\nparticipants\tO\nexperiencing\tO\nakathisia\tB-Disease\nwithin\tO\n60\tO\nminutes\tO\nof\tO\nadministration\tO\n.\tO\n\nAkathisia\tO\nwas\tO\ndefined\tO\nas\tO\neither\tO\na\tO\nspontaneous\tO\nreport\tO\nof\tO\nrestlessness\tO\nor\tO\nagitation\tB-Disease\nor\tO\na\tO\nchange\tO\nof\tO\n2\tO\nor\tO\nmore\tO\nin\tO\nthe\tO\npatient\tO\n-\tO\nreported\tO\nakathisia\tB-Disease\nrating\tO\nscale\tO\nand\tO\na\tO\nchange\tO\nof\tO\nat\tO\nleast\tO\n1\tO\nin\tO\nthe\tO\ninvestigator\tO\n-\tO\nobserved\tO\nakathisia\tB-Disease\nrating\tO\nscale\tO\n.\tO\n\nThe\tO\nintensity\tO\nof\tO\nheadache\tB-Disease\nand\tO\nnausea\tB-Disease\nwas\tO\nmeasured\tO\nwith\tO\na\tO\n100\tO\n-\tO\nmm\tO\nvisual\tO\nanalog\tO\nscale\tO\n.\tO\n\nSeventy\tO\n-\tO\nthree\tO\npercent\tO\n(\tO\n73\tO\n/\tO\n99\tO\n)\tO\nof\tO\nthe\tO\nstudy\tO\nparticipants\tO\nwere\tO\ntreated\tO\nfor\tO\nheadache\tB-Disease\nand\tO\n70\tO\n%\tO\n(\tO\n70\tO\n/\tO\n99\tO\n)\tO\nfor\tO\nnausea\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\nbolus\tO\ngroup\tO\n,\tO\n26\tO\n.\tO\n0\tO\n%\tO\n(\tO\n13\tO\n/\tO\n50\tO\n)\tO\nhad\tO\nakathisia\tB-Disease\ncompared\tO\nwith\tO\n32\tO\n.\tO\n7\tO\n%\tO\n(\tO\n16\tO\n/\tO\n49\tO\n)\tO\nin\tO\nthe\tO\ninfusion\tO\ngroup\tO\n(\tO\nDelta\tO\n=\tO\n-\tO\n6\tO\n.\tO\n7\tO\n%\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n-\tO\n24\tO\n.\tO\n6\tO\n%\tO\nto\tO\n11\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\ndifference\tO\nbetween\tO\nthe\tO\nbolus\tO\nand\tO\ninfusion\tO\ngroups\tO\nin\tO\nthe\tO\npercentage\tO\nof\tO\nparticipants\tO\nwho\tO\nsaw\tO\na\tO\n50\tO\n%\tO\nreduction\tO\nin\tO\ntheir\tO\nheadache\tB-Disease\nintensity\tO\nwithin\tO\n30\tO\nminutes\tO\nwas\tO\n11\tO\n.\tO\n8\tO\n%\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n-\tO\n9\tO\n.\tO\n6\tO\n%\tO\nto\tO\n33\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\ndifference\tO\nin\tO\nthe\tO\npercentage\tO\nof\tO\npatients\tO\nwith\tO\na\tO\n50\tO\n%\tO\nreduction\tO\nin\tO\ntheir\tO\nnausea\tB-Disease\nwas\tO\n12\tO\n.\tO\n6\tO\n%\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n-\tO\n4\tO\n.\tO\n6\tO\n%\tO\nto\tO\n29\tO\n.\tO\n8\tO\n%\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nA\tO\n50\tO\n%\tO\nreduction\tO\nin\tO\nthe\tO\nincidence\tO\nof\tO\nakathisia\tB-Disease\nwhen\tO\nprochlorperazine\tB-Chemical\nwas\tO\nadministered\tO\nby\tO\nmeans\tO\nof\tO\n15\tO\n-\tO\nminute\tO\nintravenous\tO\ninfusion\tO\nversus\tO\na\tO\n2\tO\n-\tO\nminute\tO\nintravenous\tO\npush\tO\nwas\tO\nnot\tO\ndetected\tO\n.\tO\n\nThe\tO\nefficacy\tO\nof\tO\nprochlorperazine\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nheadache\tB-Disease\nand\tO\nnausea\tB-Disease\nlikewise\tO\ndid\tO\nnot\tO\nappear\tO\nto\tO\nbe\tO\naffected\tO\nby\tO\nthe\tO\nrate\tO\nof\tO\nadministration\tO\n,\tO\nalthough\tO\nno\tO\nformal\tO\nstatistical\tO\ncomparisons\tO\nwere\tO\nmade\tO\n.\tO\n\nCombined\tO\nantiretroviral\tO\ntherapy\tO\ncauses\tO\ncardiomyopathy\tB-Disease\nand\tO\nelevates\tO\nplasma\tO\nlactate\tB-Chemical\nin\tO\ntransgenic\tO\nAIDS\tB-Disease\nmice\tO\n.\tO\n\nHighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nis\tO\nimplicated\tO\nin\tO\ncardiomyopathy\tB-Disease\n(\tO\nCM\tB-Disease\n)\tO\nand\tO\nin\tO\nelevated\tO\nplasma\tO\nlactate\tB-Chemical\n(\tO\nLA\tB-Chemical\n)\tO\nin\tO\nAIDS\tB-Disease\nthrough\tO\nmechanisms\tO\nof\tO\nmitochondrial\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nTo\tO\ndetermine\tO\nmitochondrial\tO\nevents\tO\nfrom\tO\nHAART\tO\nin\tO\nvivo\tO\n,\tO\n8\tO\n-\tO\nweek\tO\n-\tO\nold\tO\nhemizygous\tO\ntransgenic\tO\nAIDS\tB-Disease\nmice\tO\n(\tO\nNL4\tO\n-\tO\n3Delta\tO\ngag\tO\n/\tO\npol\tO\n;\tO\nTG\tO\n)\tO\nand\tO\nwild\tO\n-\tO\ntype\tO\nFVB\tO\n/\tO\nn\tO\nlittermates\tO\nwere\tO\ntreated\tO\nwith\tO\nthe\tO\nHAART\tO\ncombination\tO\nof\tO\nzidovudine\tB-Chemical\n,\tO\nlamivudine\tO\n,\tO\nand\tO\nindinavir\tB-Chemical\nor\tO\nvehicle\tO\ncontrol\tO\nfor\tO\n10\tO\ndays\tO\nor\tO\n35\tO\ndays\tO\n.\tO\n\nAt\tO\ntermination\tO\nof\tO\nthe\tO\nexperiments\tO\n,\tO\nmice\tO\nunderwent\tO\nechocardiography\tO\n,\tO\nquantitation\tO\nof\tO\nabundance\tO\nof\tO\nmolecular\tO\nmarkers\tO\nof\tO\nCM\tB-Disease\n(\tO\nventricular\tO\nmRNA\tO\nencoding\tO\natrial\tO\nnatriuretic\tO\nfactor\tO\n[\tO\nANF\tO\n]\tO\nand\tO\nsarcoplasmic\tO\ncalcium\tB-Chemical\nATPase\tO\n[\tO\nSERCA2\tO\n]\tO\n)\tO\n,\tO\nand\tO\ndetermination\tO\nof\tO\nplasma\tO\nLA\tB-Chemical\n.\tO\n\nBiochemically\tO\n,\tO\nLA\tB-Chemical\nwas\tO\nelevated\tO\n(\tO\n8\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n0\tO\nmM\tO\n)\tO\n.\tO\n\nResults\tO\nshow\tO\nthat\tO\ncumulative\tO\nHAART\tO\ncaused\tO\nmitochondrial\tO\nCM\tB-Disease\nwith\tO\nelevated\tO\nLA\tB-Chemical\nin\tO\nAIDS\tB-Disease\ntransgenic\tO\nmice\tO\n.\tO\n\nA\tO\nPhase\tO\nII\tO\ntrial\tO\nof\tO\ncisplatin\tB-Chemical\nplus\tO\nWR\tB-Chemical\n-\tI-Chemical\n2721\tI-Chemical\n(\tO\namifostine\tB-Chemical\n)\tO\nfor\tO\nmetastatic\tO\nbreast\tB-Disease\ncarcinoma\tI-Disease\n:\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nStudy\tO\n(\tO\nE8188\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCisplatin\tB-Chemical\nhas\tO\nminimal\tO\nantitumor\tO\nactivity\tO\nwhen\tO\nused\tO\nas\tO\nsecond\tO\n-\tO\nor\tO\nthird\tO\n-\tO\nline\tO\ntreatment\tO\nof\tO\nmetastatic\tO\nbreast\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nOlder\tO\nreports\tO\nsuggest\tO\nan\tO\nobjective\tO\nresponse\tO\nrate\tO\nof\tO\n8\tO\n%\tO\nwhen\tO\n60\tO\n-\tO\n120\tO\nmg\tO\n/\tO\nm2\tO\nof\tO\ncisplatin\tB-Chemical\nis\tO\nadministered\tO\nevery\tO\n3\tO\n-\tO\n4\tO\nweeks\tO\n.\tO\n\nAlthough\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\neffect\tO\nhas\tO\nbeen\tO\nobserved\tO\nwith\tO\ncisplatin\tB-Chemical\n,\tO\nthe\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicities\tB-Disease\nassociated\tO\nwith\tO\ncisplatin\tB-Chemical\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nnephrotoxicity\tB-Disease\n,\tO\nototoxicity\tB-Disease\n,\tO\nand\tO\nneurotoxicity\tB-Disease\n)\tO\nhave\tO\nlimited\tO\nits\tO\nuse\tO\nas\tO\na\tO\ntreatment\tO\nfor\tO\nbreast\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nWR\tB-Chemical\n-\tI-Chemical\n2721\tI-Chemical\nor\tO\namifostine\tB-Chemical\ninitially\tO\nwas\tO\ndeveloped\tO\nto\tO\nprotect\tO\nmilitary\tO\npersonnel\tO\nin\tO\nthe\tO\nevent\tO\nof\tO\nnuclear\tO\nwar\tO\n.\tO\n\nAmifostine\tB-Chemical\nsubsequently\tO\nwas\tO\nshown\tO\nto\tO\nprotect\tO\nnormal\tO\ntissues\tO\nfrom\tO\nthe\tO\ntoxic\tO\neffects\tO\nof\tO\nalkylating\tB-Chemical\nagents\tI-Chemical\nand\tO\ncisplatin\tB-Chemical\nwithout\tO\ndecreasing\tO\nthe\tO\nantitumor\tO\neffect\tO\nof\tO\nthe\tO\nchemotherapy\tO\n.\tO\n\nEarly\tO\ntrials\tO\nof\tO\ncisplatin\tB-Chemical\nand\tO\namifostine\tB-Chemical\nalso\tO\nsuggested\tO\nthat\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\ncisplatin\tB-Chemical\n-\tO\ninduced\tO\nnephrotoxicity\tB-Disease\n,\tO\nototoxicity\tB-Disease\n,\tO\nand\tO\nneuropathy\tB-Disease\nwere\tO\nreduced\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nPhase\tO\nII\tO\nstudy\tO\nof\tO\nthe\tO\ncombination\tO\nof\tO\ncisplatin\tB-Chemical\nplus\tO\namifostine\tB-Chemical\nwas\tO\nconducted\tO\nin\tO\npatients\tO\nwith\tO\nprogressive\tO\nmetastatic\tO\nbreast\tB-Disease\ncarcinoma\tI-Disease\nwho\tO\nhad\tO\nreceived\tO\none\tO\n,\tO\nbut\tO\nnot\tO\nmore\tO\nthan\tO\none\tO\n,\tO\nchemotherapy\tO\nregimen\tO\nfor\tO\nmetastatic\tO\ndisease\tO\n.\tO\n\nPatients\tO\nreceived\tO\namifostine\tB-Chemical\n,\tO\n910\tO\nmg\tO\n/\tO\nm2\tO\nintravenously\tO\nover\tO\n15\tO\nminutes\tO\n.\tO\n\nAfter\tO\ncompletion\tO\nof\tO\nthe\tO\namifostine\tB-Chemical\ninfusion\tO\n,\tO\ncisplatin\tB-Chemical\n120\tO\nmg\tO\n/\tO\nm2\tO\nwas\tO\nadministered\tO\nover\tO\n30\tO\nminutes\tO\n.\tO\n\nIntravenous\tO\nhydration\tO\nand\tO\nmannitol\tB-Chemical\nwas\tO\nadministered\tO\nbefore\tO\nand\tO\nafter\tO\ncisplatin\tB-Chemical\n.\tO\n\nNeurologic\tB-Disease\ntoxicity\tI-Disease\nwas\tO\nreported\tO\nin\tO\n52\tO\n%\tO\nof\tO\npatients\tO\n.\tO\n\nSeven\tO\ndifferent\tO\nlife\tO\n-\tO\nthreatening\tO\ntoxicities\tB-Disease\nwere\tO\nobserved\tO\nin\tO\npatients\tO\nwhile\tO\nreceiving\tO\ntreatment\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tO\nof\tO\ncisplatin\tB-Chemical\nand\tO\namifostine\tB-Chemical\nin\tO\nthis\tO\nstudy\tO\nresulted\tO\nin\tO\nan\tO\noverall\tO\nresponse\tO\nrate\tO\nof\tO\n16\tO\n%\tO\n.\tO\n\nNeither\tO\na\tO\ntumor\tB-Disease\n-\tO\nprotective\tO\neffect\tO\nnor\tO\nreduced\tO\ntoxicity\tB-Disease\nto\tO\nnormal\tO\ntissues\tO\nwas\tO\nobserved\tO\nwith\tO\nthe\tO\naddition\tO\nof\tO\namifostine\tB-Chemical\nto\tO\ncisplatin\tB-Chemical\nin\tO\nthis\tO\ntrial\tO\n.\tO\n\nOral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nAn\tO\nassociation\tO\nbetween\tO\nthe\tO\nuse\tO\nof\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nmyocardial\tO\ninfarction\tO\nhas\tO\nbeen\tO\nfound\tO\nin\tO\nsome\tO\n,\tO\nbut\tO\nnot\tO\nall\tO\n,\tO\nstudies\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthis\tO\nassociation\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\ntype\tO\nof\tO\nprogestagen\tB-Chemical\nincluded\tO\nin\tO\nthird\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\ndesogestrel\tO\nor\tO\ngestodene\tB-Chemical\n)\tO\nand\tO\nsecond\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nlevonorgestrel\tB-Chemical\n)\tO\noral\tO\ncontraceptives\tO\n,\tO\nthe\tO\ndose\tO\nof\tO\nestrogen\tB-Chemical\n,\tO\nand\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nprothrombotic\tO\nmutations\tO\nMETHODS\tO\n:\tO\nIn\tO\na\tO\nnationwide\tO\n,\tO\npopulation\tO\n-\tO\nbased\tO\n,\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n,\tO\nwe\tO\nidentified\tO\nand\tO\nenrolled\tO\n248\tO\nwomen\tO\n18\tO\nthrough\tO\n49\tO\nyears\tO\nof\tO\nage\tO\nwho\tO\nhad\tO\nhad\tO\na\tO\nfirst\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nbetween\tO\n1990\tO\nand\tO\n1995\tO\nand\tO\n925\tO\ncontrol\tO\nwomen\tO\nwho\tO\nhad\tO\nnot\tO\nhad\tO\na\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nand\tO\nwho\tO\nwere\tO\nmatched\tO\nfor\tO\nage\tO\n,\tO\ncalendar\tO\nyear\tO\nof\tO\nthe\tO\nindex\tO\nevent\tO\n,\tO\nand\tO\narea\tO\nof\tO\nresidence\tO\n.\tO\n\nSubjects\tO\nsupplied\tO\ninformation\tO\non\tO\noral\tB-Chemical\n-\tI-Chemical\ncontraceptive\tI-Chemical\nuse\tO\nand\tO\nmajor\tO\ncardiovascular\tO\nrisk\tO\nfactors\tO\n.\tO\n\nAn\tO\nanalysis\tO\nfor\tO\nfactor\tO\nV\tO\nLeiden\tO\nand\tO\nthe\tO\nG20210A\tO\nmutation\tO\nin\tO\nthe\tO\nprothrombin\tO\ngene\tO\nwas\tO\nconducted\tO\nin\tO\n217\tO\npatients\tO\nand\tO\n763\tO\ncontrols\tO\nRESULTS\tO\n:\tO\nThe\tO\nodds\tO\nratio\tO\nfor\tO\nmyocardial\tO\ninfarction\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nany\tO\ntype\tO\nof\tO\ncombined\tO\noral\tB-Chemical\ncontraceptive\tI-Chemical\n,\tO\nas\tO\ncompared\tO\nwith\tO\nnonusers\tO\n,\tO\nwas\tO\n2\tO\n.\tO\n0\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n2\tO\n.\tO\n8\tO\n)\tO\n.\tO\n\nThe\tO\nadjusted\tO\nodds\tO\nratio\tO\nwas\tO\n2\tO\n.\tO\n5\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n4\tO\n.\tO\n1\tO\n)\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\n1\tO\n.\tO\n3\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n7\tO\nto\tO\n2\tO\n.\tO\n5\tO\n)\tO\namong\tO\nthose\tO\nwho\tO\nused\tO\nthird\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nAmong\tO\nwomen\tO\nwho\tO\nused\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n,\tO\nthe\tO\nodds\tO\nratio\tO\nwas\tO\n2\tO\n.\tO\n1\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n3\tO\n.\tO\n0\tO\n)\tO\nfor\tO\nthose\tO\nwithout\tO\na\tO\nprothrombotic\tO\nmutation\tO\nand\tO\n1\tO\n.\tO\n9\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n6\tO\nto\tO\n5\tO\n.\tO\n5\tO\n)\tO\nfor\tO\nthose\tO\nwith\tO\na\tO\nmutation\tO\nCONCLUSIONS\tO\n:\tO\nThe\tO\nrisk\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nincreased\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nThe\tO\nresults\tO\nwith\tO\nrespect\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\nthird\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nwere\tO\ninconclusive\tO\nbut\tO\nsuggested\tO\nthat\tO\nthe\tO\nrisk\tO\nwas\tO\nlower\tO\nthan\tO\nthe\tO\nrisk\tO\nassociated\tO\nwith\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nsimilar\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nwhether\tO\nor\tO\nnot\tO\nthey\tO\nhad\tO\na\tO\nprothrombotic\tO\nmutation\tO\n.\tO\n\nEnd\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n(\tO\nESRD\tB-Disease\n)\tO\nafter\tO\northotopic\tO\nliver\tO\ntransplantation\tO\n(\tO\nOLTX\tO\n)\tO\nusing\tO\ncalcineurin\tO\n-\tO\nbased\tO\nimmunotherapy\tO\n:\tO\nrisk\tO\nof\tO\ndevelopment\tO\nand\tO\ntreatment\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\ncalcineurin\tO\ninhibitors\tO\ncyclosporine\tB-Chemical\nand\tO\ntacrolimus\tB-Chemical\nare\tO\nboth\tO\nknown\tO\nto\tO\nbe\tO\nnephrotoxic\tB-Disease\n.\tO\n\nRecently\tO\n,\tO\nhowever\tO\n,\tO\nwe\tO\nhave\tO\nhad\tO\nan\tO\nincrease\tO\nof\tO\npatients\tO\nwho\tO\nare\tO\npresenting\tO\nafter\tO\nOLTX\tO\nwith\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n(\tO\nESRD\tB-Disease\n)\tO\n.\tO\n\nThis\tO\nretrospective\tO\nstudy\tO\nexamines\tO\nthe\tO\nincidence\tO\nand\tO\ntreatment\tO\nof\tO\nESRD\tB-Disease\nand\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n(\tO\nCRF\tB-Disease\n)\tO\nin\tO\nOLTX\tO\npatients\tO\n.\tO\n\nPatients\tO\nwere\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n:\tO\nControls\tO\n,\tO\nno\tO\nCRF\tB-Disease\nor\tO\nESRD\tB-Disease\n,\tO\nn\tO\n=\tO\n748\tO\n;\tO\nCRF\tB-Disease\n,\tO\nsustained\tO\nserum\tO\ncreatinine\tB-Chemical\n>\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nn\tO\n=\tO\n41\tO\n;\tO\nand\tO\nESRD\tB-Disease\n,\tO\nn\tO\n=\tO\n45\tO\n.\tO\n\nGroups\tO\nwere\tO\ncompared\tO\nfor\tO\npreoperative\tO\nlaboratory\tO\nvariables\tO\n,\tO\ndiagnosis\tO\n,\tO\npostoperative\tO\nvariables\tO\n,\tO\nsurvival\tO\n,\tO\ntype\tO\nof\tO\nESRD\tB-Disease\ntherapy\tO\n,\tO\nand\tO\nsurvival\tO\nfrom\tO\nonset\tO\nof\tO\nESRD\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nAt\tO\n13\tO\nyears\tO\nafter\tO\nOLTX\tO\n,\tO\nthe\tO\nincidence\tO\nof\tO\nsevere\tO\nrenal\tB-Disease\ndysfunction\tI-Disease\nwas\tO\n18\tO\n.\tO\n1\tO\n%\tO\n(\tO\nCRF\tB-Disease\n8\tO\n.\tO\n6\tO\n%\tO\nand\tO\nESRD\tB-Disease\n9\tO\n.\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nCompared\tO\nwith\tO\ncontrol\tO\npatients\tO\n,\tO\nCRF\tB-Disease\nand\tO\nESRD\tB-Disease\npatients\tO\nhad\tO\nhigher\tO\npreoperative\tO\nserum\tO\ncreatinine\tB-Chemical\nlevels\tO\n,\tO\na\tO\ngreater\tO\npercentage\tO\nof\tO\npatients\tO\nwith\tO\nhepatorenal\tB-Disease\nsyndrome\tI-Disease\n,\tO\nhigher\tO\npercentage\tO\nrequirement\tO\nfor\tO\ndialysis\tO\nin\tO\nthe\tO\nfirst\tO\n3\tO\nmonths\tO\npostoperatively\tO\n,\tO\nand\tO\na\tO\nhigher\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tB-Chemical\n.\tO\n\nMultivariate\tO\nstepwise\tO\nlogistic\tO\nregression\tO\nanalysis\tO\nusing\tO\npreoperative\tO\nand\tO\npostoperative\tO\nvariables\tO\nidentified\tO\nthat\tO\nan\tO\nincrease\tO\nof\tO\nserum\tO\ncreatinine\tB-Chemical\ncompared\tO\nwith\tO\naverage\tO\nat\tO\n1\tO\nyear\tO\n,\tO\n3\tO\nmonths\tO\n,\tO\nand\tO\n4\tO\nweeks\tO\npostoperatively\tO\nwere\tO\nindependent\tO\nrisk\tO\nfactors\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nCRF\tB-Disease\nor\tO\nESRD\tB-Disease\nwith\tO\nodds\tO\nratios\tO\nof\tO\n2\tO\n.\tO\n6\tO\n,\tO\n2\tO\n.\tO\n2\tO\n,\tO\nand\tO\n1\tO\n.\tO\n6\tO\n,\tO\nrespectively\tO\n.\tO\n\nOverall\tO\nsurvival\tO\nfrom\tO\nthe\tO\ntime\tO\nof\tO\nOLTX\tO\nwas\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\namong\tO\ngroups\tO\n,\tO\nbut\tO\nby\tO\nyear\tO\n13\tO\n,\tO\nthe\tO\nsurvival\tO\nof\tO\nthe\tO\npatients\tO\nwho\tO\nhad\tO\nESRD\tB-Disease\nwas\tO\nonly\tO\n28\tO\n.\tO\n2\tO\n%\tO\ncompared\tO\nwith\tO\n54\tO\n.\tO\n6\tO\n%\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nPatients\tO\ndeveloping\tO\nESRD\tB-Disease\nhad\tO\na\tO\n6\tO\n-\tO\nyear\tO\nsurvival\tO\nafter\tO\nonset\tO\nof\tO\nESRD\tB-Disease\nof\tO\n27\tO\n%\tO\nfor\tO\nthe\tO\npatients\tO\nreceiving\tO\nhemodialysis\tO\nversus\tO\n71\tO\n.\tO\n4\tO\n%\tO\nfor\tO\nthe\tO\npatients\tO\ndeveloping\tO\nESRD\tB-Disease\nwho\tO\nsubsequently\tO\nreceived\tO\nkidney\tO\ntransplants\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPatients\tO\nwho\tO\nare\tO\nmore\tO\nthan\tO\n10\tO\nyears\tO\npost\tO\n-\tO\nOLTX\tO\nhave\tO\nCRF\tB-Disease\nand\tO\nESRD\tB-Disease\nat\tO\na\tO\nhigh\tO\nrate\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nESRD\tB-Disease\ndecreases\tO\nsurvival\tO\n,\tO\nparticularly\tO\nin\tO\nthose\tO\npatients\tO\ntreated\tO\nwith\tO\ndialysis\tO\nonly\tO\n.\tO\n\nPatients\tO\nwho\tO\ndevelop\tO\nESRD\tB-Disease\nhave\tO\na\tO\nhigher\tO\npreoperative\tO\nand\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tB-Chemical\nand\tO\nare\tO\nmore\tO\nlikely\tO\nto\tO\nhave\tO\nhepatorenal\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nan\tO\nincrease\tO\nof\tO\nserum\tO\ncreatinine\tB-Chemical\nat\tO\nvarious\tO\ntimes\tO\npostoperatively\tO\nis\tO\nmore\tO\npredictive\tO\nof\tO\nthe\tO\ndevelopment\tO\nof\tO\nCRF\tB-Disease\nor\tO\nESRD\tB-Disease\n.\tO\n\nEpileptic\tB-Disease\nseizures\tI-Disease\nfollowing\tO\ncortical\tO\napplication\tO\nof\tO\nfibrin\tO\nsealants\tO\ncontaining\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\nin\tO\nrats\tO\n.\tO\n\nRecently\tO\n,\tO\nsynthetic\tO\nfibrinolysis\tO\ninhibitors\tO\nsuch\tO\nas\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\n(\tO\ntAMCA\tB-Chemical\n)\tO\nhave\tO\nbeen\tO\nconsidered\tO\nas\tO\nsubstitutes\tO\nfor\tO\naprotinin\tO\n.\tO\n\nHowever\tO\n,\tO\ntAMCA\tB-Chemical\nhas\tO\nbeen\tO\nshown\tO\nto\tO\ncause\tO\nepileptic\tB-Disease\nseizures\tI-Disease\n.\tO\n\nWe\tO\nwanted\tO\nto\tO\nstudy\tO\nwhether\tO\ntAMCA\tB-Chemical\nretains\tO\nits\tO\nconvulsive\tB-Disease\naction\tO\nif\tO\nincorporated\tO\ninto\tO\na\tO\nFS\tO\n.\tO\n\nMETHOD\tO\n:\tO\nFS\tO\ncontaining\tO\naprotinin\tO\nor\tO\ndifferent\tO\nconcentrations\tO\nof\tO\ntAMCA\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\n-\tO\n47\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\n)\tO\nwere\tO\napplied\tO\nto\tO\nthe\tO\npial\tO\nsurface\tO\nof\tO\nthe\tO\ncortex\tO\nof\tO\nanaesthetized\tO\nrats\tO\n.\tO\n\nFINDINGS\tO\n:\tO\nFS\tO\ncontaining\tO\ntAMCA\tB-Chemical\ncaused\tO\nparoxysmal\tO\nbrain\tO\nactivity\tO\nwhich\tO\nwas\tO\nassociated\tO\nwith\tO\ndistinct\tO\nconvulsive\tB-Disease\nbehaviours\tO\n.\tO\n\nThe\tO\ndegree\tO\nof\tO\nthese\tO\nseizures\tB-Disease\nincreased\tO\nwith\tO\nincreasing\tO\nconcentration\tO\nof\tO\ntAMCA\tB-Chemical\n.\tO\n\nThus\tO\n,\tO\nFS\tO\ncontaining\tO\n47\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\ntAMCA\tB-Chemical\nevoked\tO\ngeneralized\tB-Disease\nseizures\tI-Disease\nin\tO\nall\tO\ntested\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nwhile\tO\nthe\tO\nlowest\tO\nconcentration\tO\nof\tO\ntAMCA\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\n)\tO\nonly\tO\nevoked\tO\nbrief\tO\nepisodes\tO\nof\tO\njerk\tO\n-\tO\ncorrelated\tO\nconvulsive\tB-Disease\npotentials\tO\nin\tO\n1\tO\nof\tO\n6\tO\nrats\tO\n.\tO\n\nINTERPRETATION\tO\n:\tO\nTranexamic\tB-Chemical\nacid\tI-Chemical\nretains\tO\nits\tO\nconvulsive\tB-Disease\naction\tO\nwithin\tO\nFS\tO\n.\tO\n\nThus\tO\n,\tO\nuse\tO\nof\tO\nFS\tO\ncontaining\tO\ntAMCA\tB-Chemical\nfor\tO\nsurgery\tO\nwithin\tO\nor\tO\nclose\tO\nto\tO\nthe\tO\nCNS\tO\nmay\tO\npose\tO\na\tO\nsubstantial\tO\nrisk\tO\nto\tO\nthe\tO\npatient\tO\n.\tO\n\nSequential\tO\nobservations\tO\nof\tO\nexencephaly\tB-Disease\nand\tO\nsubsequent\tO\nmorphological\tO\nchanges\tO\nby\tO\nmouse\tO\nexo\tO\nutero\tO\ndevelopment\tO\nsystem\tO\n:\tO\nanalysis\tO\nof\tO\nthe\tO\nmechanism\tO\nof\tO\ntransformation\tO\nfrom\tO\nexencephaly\tB-Disease\nto\tO\nanencephaly\tB-Disease\n.\tO\n\nAnencephaly\tB-Disease\nhas\tO\nbeen\tO\nsuggested\tO\nto\tO\ndevelop\tO\nfrom\tO\nexencephaly\tB-Disease\n;\tO\nhowever\tO\n,\tO\nthere\tO\nis\tO\nlittle\tO\ndirect\tO\nexperimental\tO\nevidence\tO\nto\tO\nsupport\tO\nthis\tO\n,\tO\nand\tO\nthe\tO\nmechanism\tO\nof\tO\ntransformation\tO\nremains\tO\nunclear\tO\n.\tO\n\nWe\tO\nobserved\tO\nthe\tO\nexencephaly\tB-Disease\ninduced\tO\nby\tO\n5\tB-Chemical\n-\tI-Chemical\nazacytidine\tI-Chemical\nat\tO\nembryonic\tO\nday\tO\n13\tO\n.\tO\n5\tO\n(\tO\nE13\tO\n.\tO\n5\tO\n)\tO\n,\tO\nlet\tO\nthe\tO\nembryos\tO\ndevelop\tO\nexo\tO\nutero\tO\nuntil\tO\nE18\tO\n.\tO\n5\tO\n,\tO\nand\tO\nre\tO\n-\tO\nobserved\tO\nthe\tO\nsame\tO\nembryos\tO\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nWe\tO\nconfirmed\tO\nseveral\tO\ncases\tO\nof\tO\ntransformation\tO\nfrom\tO\nexencephaly\tB-Disease\nto\tO\nanencephaly\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nin\tO\nmany\tO\ncases\tO\n,\tO\nthe\tO\nexencephalic\tB-Disease\nbrain\tO\ntissue\tO\nwas\tO\npreserved\tO\nwith\tO\nmore\tO\nor\tO\nless\tO\nreduction\tO\nduring\tO\nthis\tO\nperiod\tO\n.\tO\n\nTo\tO\nanalyze\tO\nthe\tO\ntransformation\tO\npatterns\tO\n,\tO\nwe\tO\nclassified\tO\nthe\tO\nexencephaly\tB-Disease\nby\tO\nsize\tO\nand\tO\nshape\tO\nof\tO\nthe\tO\nexencephalic\tB-Disease\ntissue\tO\ninto\tO\nseveral\tO\ntypes\tO\nat\tO\nE13\tO\n.\tO\n5\tO\nand\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nIt\tO\nwas\tO\nfound\tO\nthat\tO\nthe\tO\ntransformation\tO\nof\tO\nexencephalic\tB-Disease\ntissue\tO\nwas\tO\nnot\tO\nsimply\tO\nsize\tO\n-\tO\ndependent\tO\n,\tO\nand\tO\nall\tO\ncases\tO\nof\tO\nanencephaly\tB-Disease\nat\tO\nE18\tO\n.\tO\n5\tO\nresulted\tO\nfrom\tO\nembryos\tO\nwith\tO\na\tO\nlarge\tO\namount\tO\nof\tO\nexencephalic\tB-Disease\ntissue\tO\nat\tO\nE13\tO\n.\tO\n5\tO\n.\tO\n\nMicroscopic\tO\nobservation\tO\nshowed\tO\nthe\tO\nconfiguration\tO\nof\tO\nexencephaly\tB-Disease\nat\tO\nE13\tO\n.\tO\n5\tO\n,\tO\nfrequent\tO\nhemorrhaging\tB-Disease\nand\tO\ndetachment\tO\nof\tO\nthe\tO\nneural\tO\nplate\tO\nfrom\tO\nsurface\tO\nectoderm\tO\nin\tO\nthe\tO\nexencephalic\tB-Disease\nhead\tO\nat\tO\nE15\tO\n.\tO\n5\tO\n,\tO\nand\tO\nmultiple\tO\nmodes\tO\nof\tO\nreduction\tO\nin\tO\nthe\tO\nexencephalic\tB-Disease\ntissue\tO\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nFrom\tO\nobservations\tO\nof\tO\nthe\tO\nvasculature\tO\n,\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\nwere\tO\nidentified\tO\nin\tO\nthe\tO\nexencephalic\tB-Disease\nhead\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\novergrowth\tO\nof\tO\nthe\tO\nexencephalic\tB-Disease\nneural\tO\ntissue\tO\ncauses\tO\nthe\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\n,\tO\nsubsequent\tO\nperipheral\tO\ncirculatory\tB-Disease\nfailure\tI-Disease\nand\tO\n/\tO\nor\tO\nhemorrhaging\tB-Disease\nin\tO\nvarious\tO\nparts\tO\nof\tO\nthe\tO\nexencephalic\tB-Disease\nhead\tO\n,\tO\nleading\tO\nto\tO\nthe\tO\nmultiple\tO\nmodes\tO\nof\tO\ntissue\tO\nreduction\tO\nduring\tO\ntransformation\tO\nfrom\tO\nexencephaly\tB-Disease\nto\tO\nanencephaly\tB-Disease\n.\tO\n\n99mTc\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nfor\tO\ndetection\tO\nof\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nInfarct\tO\n-\tO\navid\tO\nradiopharmaceuticals\tO\nare\tO\nnecessary\tO\nfor\tO\nrapid\tO\nand\tO\ntimely\tO\ndiagnosis\tO\nof\tO\nacute\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nThe\tO\nanimal\tO\nmodel\tO\nused\tO\nto\tO\nproduce\tO\ninfarction\tB-Disease\nimplies\tO\nartery\tO\nligation\tO\nbut\tO\nchemical\tO\ninduction\tO\ncan\tO\nbe\tO\neasily\tO\nobtained\tO\nwith\tO\nisoproterenol\tB-Chemical\n.\tO\n\nA\tO\nnew\tO\ninfarct\tB-Disease\n-\tO\navid\tO\nradiopharmaceutical\tO\nbased\tO\non\tO\nglucaric\tB-Chemical\nacid\tI-Chemical\nwas\tO\nprepared\tO\nin\tO\nthe\tO\nhospital\tO\nradiopharmacy\tO\nof\tO\nthe\tO\nINCMNSZ\tO\n.\tO\n\n99mTc\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nwas\tO\neasy\tO\nto\tO\nprepare\tO\n,\tO\nstable\tO\nfor\tO\n96\tO\nh\tO\nand\tO\nwas\tO\nused\tO\nto\tO\nstudy\tO\nits\tO\nbiodistribution\tO\nin\tO\nrats\tO\nwith\tO\nisoproterenol\tB-Chemical\n-\tO\ninduced\tO\nacute\tO\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nHistological\tO\nstudies\tO\ndemonstrated\tO\nthat\tO\nthe\tO\nrats\tO\ndeveloped\tO\nan\tO\ninfarct\tB-Disease\n18\tO\nh\tO\nafter\tO\nisoproterenol\tB-Chemical\nadministration\tO\n.\tO\n\nThirty\tO\nminutes\tO\nafter\tO\n99mTc\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nadministration\tO\nthe\tO\nstandardised\tO\nheart\tO\nuptake\tO\nvalue\tO\nS\tO\n(\tO\nh\tO\n)\tO\nUV\tO\nwas\tO\n4\tO\n.\tO\n7\tO\nin\tO\ninfarcted\tO\nrat\tO\nheart\tO\nwhich\tO\nis\tO\nsix\tO\ntimes\tO\nmore\tO\nthan\tO\nin\tO\nnormal\tO\nrats\tO\n.\tO\n\nThe\tO\nhigh\tO\nimage\tO\nquality\tO\nsuggests\tO\nthat\tO\nhigh\tO\ncontrast\tO\nimages\tO\ncan\tO\nbe\tO\nobtained\tO\nin\tO\nhumans\tO\nand\tO\nthe\tO\n96\tO\nh\tO\nstability\tO\nmakes\tO\nit\tO\nan\tO\nideal\tO\nagent\tO\nto\tO\ndetect\tO\n,\tO\nin\tO\npatients\tO\n,\tO\nearly\tO\ncardiac\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nBupropion\tB-Chemical\n(\tO\nZyban\tB-Chemical\n)\tO\ntoxicity\tB-Disease\n.\tO\n\nBupropion\tB-Chemical\nis\tO\na\tO\nmonocyclic\tO\nantidepressant\tB-Chemical\nstructurally\tO\nrelated\tO\nto\tO\namphetamine\tB-Chemical\n.\tO\n\nZyban\tB-Chemical\n,\tO\na\tO\nsustained\tO\n-\tO\nrelease\tO\nformulation\tO\nof\tO\nbupropion\tB-Chemical\nhydrochloride\tI-Chemical\n,\tO\nwas\tO\nrecently\tO\nreleased\tO\nin\tO\nIreland\tO\n,\tO\nas\tO\na\tO\nsmoking\tO\ncessation\tO\naid\tO\n.\tO\n\nIn\tO\nthe\tO\ninitial\tO\n6\tO\nmonths\tO\nsince\tO\nit\tO\n'\tO\ns\tO\nintroduction\tO\n,\tO\n12\tO\noverdose\tB-Disease\ncases\tO\nhave\tO\nbeen\tO\nreported\tO\nto\tO\nThe\tO\nNational\tO\nPoisons\tO\nInformation\tO\nCentre\tO\n.\tO\n\n8\tO\npatients\tO\ndeveloped\tO\nsymptoms\tO\nof\tO\ntoxicity\tB-Disease\n.\tO\n\nCommon\tO\nfeatures\tO\nincluded\tO\ntachycardia\tB-Disease\n,\tO\ndrowsiness\tO\n,\tO\nhallucinations\tB-Disease\nand\tO\nconvulsions\tB-Disease\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\nsevere\tO\ncardiac\tB-Disease\narrhythmias\tI-Disease\n,\tO\nincluding\tO\none\tO\npatient\tO\nwho\tO\nwas\tO\nresuscitated\tO\nfollowing\tO\na\tO\ncardiac\tB-Disease\narrest\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\n31\tO\nyear\tO\nold\tO\nfemale\tO\nwho\tO\nrequired\tO\nadmission\tO\nto\tO\nthe\tO\nIntensive\tO\nCare\tO\nUnit\tO\nfor\tO\nventilation\tO\nand\tO\nfull\tO\nsupportive\tO\ntherapy\tO\n,\tO\nfollowing\tO\ningestion\tO\nof\tO\n13\tO\n.\tO\n5g\tO\nbupropion\tB-Chemical\n.\tO\n\nRecurrent\tO\nseizures\tB-Disease\nwere\tO\ntreated\tO\nwith\tO\ndiazepam\tB-Chemical\nand\tO\nbroad\tO\ncomplex\tO\ntachycardia\tB-Disease\nwas\tO\nsuccessfully\tO\ntreated\tO\nwith\tO\nadenosine\tB-Chemical\n.\tO\n\nZyban\tB-Chemical\ncaused\tO\nsignificant\tO\nneurological\tB-Disease\nand\tI-Disease\ncardiovascular\tI-Disease\ntoxicity\tI-Disease\nin\tO\noverdose\tB-Disease\n.\tO\n\nGLEPP1\tO\nreceptor\tO\ntyrosine\tB-Chemical\nphosphatase\tO\n(\tO\nPtpro\tO\n)\tO\nin\tO\nrat\tO\nPAN\tB-Chemical\nnephrosis\tB-Disease\n.\tO\n\nGlomerular\tO\nepithelial\tO\nprotein\tO\n1\tO\n(\tO\nGLEPP1\tO\n)\tO\nis\tO\na\tO\npodocyte\tO\nreceptor\tO\nmembrane\tO\nprotein\tO\ntyrosine\tB-Chemical\nphosphatase\tO\nlocated\tO\non\tO\nthe\tO\napical\tO\ncell\tO\nmembrane\tO\nof\tO\nvisceral\tO\nglomerular\tO\nepithelial\tO\ncell\tO\nand\tO\nfoot\tO\nprocesses\tO\n.\tO\n\nTo\tO\nbetter\tO\nunderstand\tO\nthe\tO\nutility\tO\nof\tO\nGLEPP1\tO\nas\tO\na\tO\nmarker\tO\nof\tO\nglomerular\tB-Disease\ninjury\tI-Disease\n,\tO\nthe\tO\namount\tO\nand\tO\ndistribution\tO\nof\tO\nGLEPP1\tO\nprotein\tO\nand\tO\nmRNA\tO\nwere\tO\nexamined\tO\nby\tO\nimmunohistochemistry\tO\n,\tO\nWestern\tO\nblot\tO\nand\tO\nRNase\tO\nprotection\tO\nassay\tO\nin\tO\na\tO\nmodel\tO\nof\tO\npodocyte\tO\ninjury\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nPuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nnephrosis\tB-Disease\nwas\tO\ninduced\tO\nby\tO\nsingle\tO\nintraperitoneal\tO\ninjection\tO\nof\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n,\tO\n20\tO\nmg\tO\n/\tO\n100g\tO\nBW\tO\n)\tO\n.\tO\n\nTissues\tO\nwere\tO\nanalyzed\tO\nat\tO\n0\tO\n,\tO\n5\tO\n,\tO\n7\tO\n,\tO\n11\tO\n,\tO\n21\tO\n,\tO\n45\tO\n,\tO\n80\tO\nand\tO\n126\tO\ndays\tO\nafter\tO\nPAN\tB-Chemical\ninjection\tO\nso\tO\nas\tO\nto\tO\ninclude\tO\nboth\tO\nthe\tO\nacute\tO\nphase\tO\nof\tO\nproteinuria\tB-Disease\nassociated\tO\nwith\tO\nfoot\tO\nprocess\tO\neffacement\tO\n(\tO\ndays\tO\n5\tO\n-\tO\n11\tO\n)\tO\nand\tO\nthe\tO\nchronic\tO\nphase\tO\nof\tO\nproteinuria\tB-Disease\nassociated\tO\nwith\tO\nglomerulosclerosis\tB-Disease\n(\tO\ndays\tO\n45\tO\n-\tO\n126\tO\n)\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nGLEPP1\tO\nexpression\tO\n,\tO\nunlike\tO\npodocalyxin\tO\n,\tO\nreflects\tO\npodocyte\tO\ninjury\tO\ninduced\tO\nby\tO\nPAN\tB-Chemical\n.\tO\n\nAntithymocyte\tB-Chemical\nglobulin\tI-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n-\tO\ninduced\tO\naplastic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nA\tO\npatient\tO\nwho\tO\nreceived\tO\nantithymocyte\tB-Chemical\nglobulin\tI-Chemical\ntherapy\tO\nfor\tO\naplastic\tB-Disease\nanemia\tI-Disease\ndue\tO\nto\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\ntherapy\tO\nis\tO\ndescribed\tO\n.\tO\n\nUse\tO\nof\tO\nantithymocyte\tB-Chemical\nglobulin\tI-Chemical\nmay\tO\nbe\tO\nthe\tO\noptimal\tO\ntreatment\tO\nof\tO\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n-\tO\ninduced\tO\naplastic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nMetamizol\tB-Chemical\npotentiates\tO\nmorphine\tB-Chemical\nantinociception\tO\nbut\tO\nnot\tO\nconstipation\tB-Disease\nafter\tO\nchronic\tO\ntreatment\tO\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\nantinociceptive\tO\nand\tO\nconstipating\tB-Disease\neffects\tO\nof\tO\nthe\tO\ncombination\tO\nof\tO\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nmorphine\tB-Chemical\nwith\tO\n177\tO\n.\tO\n8\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nmetamizol\tB-Chemical\nin\tO\nacutely\tO\nand\tO\nchronically\tO\ntreated\tO\n(\tO\nonce\tO\na\tO\nday\tO\nfor\tO\n12\tO\ndays\tO\n)\tO\nrats\tO\n.\tO\n\nOn\tO\nthe\tO\n13th\tO\nday\tO\n,\tO\nantinociceptive\tO\neffects\tO\nwere\tO\nassessed\tO\nusing\tO\na\tO\nmodel\tO\nof\tO\ninflammatory\tO\nnociception\tO\n,\tO\npain\tB-Disease\n-\tO\ninduced\tO\nfunctional\tO\nimpairment\tO\nmodel\tO\n,\tO\nand\tO\nthe\tO\ncharcoal\tB-Chemical\nmeal\tO\ntest\tO\nwas\tO\nused\tO\nto\tO\nevaluate\tO\nthe\tO\nintestinal\tO\ntransit\tO\n.\tO\n\nSimultaneous\tO\nadministration\tO\nof\tO\nmorphine\tB-Chemical\nwith\tO\nmetamizol\tB-Chemical\nresulted\tO\nin\tO\na\tO\nmarkedly\tO\nantinociceptive\tO\npotentiation\tO\nand\tO\nan\tO\nincreasing\tO\nof\tO\nthe\tO\nduration\tO\nof\tO\naction\tO\nafter\tO\na\tO\nsingle\tO\n(\tO\n298\tO\n+\tO\n/\tO\n-\tO\n7\tO\nvs\tO\n.\tO\n139\tO\n+\tO\n/\tO\n-\tO\n36\tO\nunits\tO\narea\tO\n(\tO\nua\tO\n)\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\nrepeated\tO\nadministration\tO\n(\tO\n280\tO\n+\tO\n/\tO\n-\tO\n17\tO\nvs\tO\n.\tO\n131\tO\n+\tO\n/\tO\n-\tO\n22\tO\nua\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nAntinociceptive\tO\neffect\tO\nof\tO\nmorphine\tB-Chemical\nwas\tO\nreduced\tO\nin\tO\nchronically\tO\ntreated\tO\nrats\tO\n(\tO\n39\tO\n+\tO\n/\tO\n-\tO\n10\tO\nvs\tO\n.\tO\n18\tO\n+\tO\n/\tO\n-\tO\n5\tO\nau\tO\n)\tO\nwhile\tO\nthe\tO\ncombination\tO\n-\tO\ninduced\tO\nantinociception\tO\nwas\tO\nremained\tO\nsimilar\tO\nas\tO\nan\tO\nacute\tO\ntreatment\tO\n(\tO\n298\tO\n+\tO\n/\tO\n-\tO\n7\tO\nvs\tO\n.\tO\n280\tO\n+\tO\n/\tO\n-\tO\n17\tO\nau\tO\n)\tO\n.\tO\n\nAcute\tO\nantinociceptive\tO\neffects\tO\nof\tO\nthe\tO\ncombination\tO\nwere\tO\npartially\tO\nprevented\tO\nby\tO\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nnaloxone\tB-Chemical\ns\tO\n.\tO\nc\tO\n.\tO\n\nIn\tO\nindependent\tO\ngroups\tO\n,\tO\nmorphine\tB-Chemical\ninhibited\tO\nthe\tO\nintestinal\tO\ntransit\tO\nin\tO\n48\tO\n+\tO\n/\tO\n-\tO\n4\tO\n%\tO\nand\tO\n38\tO\n+\tO\n/\tO\n-\tO\n4\tO\n%\tO\nafter\tO\nacute\tO\nand\tO\nchronic\tO\ntreatment\tO\n,\tO\nrespectively\tO\n,\tO\nsuggesting\tO\nthat\tO\ntolerance\tO\ndid\tO\nnot\tO\ndevelop\tO\nto\tO\nthe\tO\nconstipating\tB-Disease\neffects\tO\n.\tO\n\nThe\tO\ncombination\tO\ninhibited\tO\nintestinal\tO\ntransit\tO\nsimilar\tO\nto\tO\nthat\tO\nproduced\tO\nby\tO\nmorphine\tB-Chemical\nregardless\tO\nof\tO\nthe\tO\ntime\tO\nof\tO\ntreatment\tO\n,\tO\nsuggesting\tO\nthat\tO\nmetamizol\tB-Chemical\ndid\tO\nnot\tO\npotentiate\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nconstipation\tB-Disease\n.\tO\n\nThese\tO\nfindings\tO\nshow\tO\na\tO\nsignificant\tO\ninteraction\tO\nbetween\tO\nmorphine\tB-Chemical\nand\tO\nmetamizol\tB-Chemical\nin\tO\nchronically\tO\ntreated\tO\nrats\tO\n,\tO\nsuggesting\tO\nthat\tO\nthis\tO\ncombination\tO\ncould\tO\nbe\tO\nuseful\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nchronic\tB-Disease\npain\tI-Disease\n.\tO\n\nIfosfamide\tB-Chemical\nencephalopathy\tB-Disease\npresenting\tO\nwith\tO\nasterixis\tB-Disease\n.\tO\n\nCNS\tO\ntoxic\tO\neffects\tO\nof\tO\nthe\tO\nantineoplastic\tO\nagent\tO\nifosfamide\tB-Chemical\n(\tO\nIFX\tB-Chemical\n)\tO\nare\tO\nfrequent\tO\nand\tO\ninclude\tO\na\tO\nvariety\tO\nof\tO\nneurological\tO\nsymptoms\tO\nthat\tO\ncan\tO\nlimit\tO\ndrug\tO\nuse\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\n51\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\ndeveloped\tO\nsevere\tO\n,\tO\ndisabling\tO\nnegative\tO\nmyoclonus\tB-Disease\nof\tO\nthe\tO\nupper\tO\nand\tO\nlower\tO\nextremities\tO\nafter\tO\nthe\tO\ninfusion\tO\nof\tO\nifosfamide\tB-Chemical\nfor\tO\nplasmacytoma\tB-Disease\n.\tO\n\nCranial\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nextensive\tO\nlaboratory\tO\nstudies\tO\nfailed\tO\nto\tO\nreveal\tO\nstructural\tB-Disease\nlesions\tI-Disease\nof\tI-Disease\nthe\tI-Disease\nbrain\tI-Disease\nand\tO\nmetabolic\tB-Disease\nabnormalities\tI-Disease\n.\tO\n\nAn\tO\nelectroencephalogram\tO\nshowed\tO\ncontinuous\tO\n,\tO\ngeneralized\tO\nirregular\tO\nslowing\tO\nwith\tO\nadmixed\tO\nperiodic\tO\ntriphasic\tO\nwaves\tO\nindicating\tO\nsymptomatic\tO\nencephalopathy\tB-Disease\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nifosfamide\tB-Chemical\nwas\tO\ndiscontinued\tO\nand\tO\nwithin\tO\n12\tO\nh\tO\nthe\tO\nasterixis\tB-Disease\nresolved\tO\ncompletely\tO\n.\tO\n\nIn\tO\nthe\tO\npatient\tO\ndescribed\tO\n,\tO\nthe\tO\npresence\tO\nof\tO\nasterixis\tB-Disease\nduring\tO\ninfusion\tO\nof\tO\nifosfamide\tB-Chemical\n,\tO\nnormal\tO\nlaboratory\tO\nfindings\tO\nand\tO\nimaging\tO\nstudies\tO\nand\tO\nthe\tO\nresolution\tO\nof\tO\nsymptoms\tO\nfollowing\tO\nthe\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nsuggest\tO\nthat\tO\nnegative\tO\nmyoclonus\tB-Disease\nis\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nIFX\tB-Chemical\n.\tO\n\nAntagonism\tO\nbetween\tO\ninterleukin\tO\n3\tO\nand\tO\nerythropoietin\tO\nin\tO\nmice\tO\nwith\tO\nazidothymidine\tB-Chemical\n-\tO\ninduced\tO\nanemia\tB-Disease\nand\tO\nin\tO\nbone\tO\nmarrow\tO\nendothelial\tO\ncells\tO\n.\tO\n\nAzidothymidine\tB-Chemical\n(\tO\nAZT\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nin\tO\nmice\tO\ncan\tO\nbe\tO\nreversed\tO\nby\tO\nthe\tO\nadministration\tO\nof\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\n(\tO\nfusion\tO\nprotein\tO\nof\tO\ninsulin\tO\n-\tO\nlike\tO\ngrowth\tO\nfactor\tO\nII\tO\n(\tO\nIGF\tO\nII\tO\n)\tO\nand\tO\ninterleukin\tO\n3\tO\n)\tO\n.\tO\n\nAlthough\tO\ninterleukin\tO\n3\tO\n(\tO\nIL\tO\n-\tO\n3\tO\n)\tO\nand\tO\nerythropoietin\tO\n(\tO\nEPO\tO\n)\tO\nare\tO\nknown\tO\nto\tO\nact\tO\nsynergistically\tO\non\tO\nhematopoietic\tO\ncell\tO\nproliferation\tO\nin\tO\nvitro\tO\n,\tO\ninjection\tO\nof\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\nand\tO\nEPO\tO\nin\tO\nAZT\tB-Chemical\n-\tO\ntreated\tO\nmice\tO\nresulted\tO\nin\tO\na\tO\nreduction\tO\nof\tO\nred\tO\ncells\tO\nand\tO\nan\tO\nincrease\tO\nof\tO\nplasma\tO\nEPO\tO\nlevels\tO\nas\tO\ncompared\tO\nto\tO\nanimals\tO\ntreated\tO\nwith\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\nor\tO\nEPO\tO\nalone\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\nreduction\tO\nof\tO\nthymidine\tB-Chemical\nincorporation\tO\ninto\tO\nboth\tO\nerythroid\tO\nand\tO\nendothelial\tO\ncells\tO\nin\tO\ncultures\tO\npre\tO\n-\tO\ntreated\tO\nwith\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\nand\tO\nEPO\tO\n.\tO\n\nEndothelial\tO\ncell\tO\nculture\tO\nsupernatants\tO\nseparated\tO\nby\tO\nultrafiltration\tO\nand\tO\nultracentrifugation\tO\nfrom\tO\ncells\tO\ntreated\tO\nwith\tO\nEPO\tO\nand\tO\nIL\tO\n-\tO\n3\tO\nsignificantly\tO\nreduced\tO\nthymidine\tB-Chemical\nincorporation\tO\ninto\tO\nerythroid\tO\ncells\tO\nas\tO\ncompared\tO\nto\tO\nidentical\tO\nfractions\tO\nobtained\tO\nfrom\tO\nthe\tO\nmedia\tO\nof\tO\ncells\tO\ncultured\tO\nwith\tO\nEPO\tO\nalone\tO\n.\tO\n\nThe\tO\nrelationship\tO\nbetween\tO\nhippocampal\tO\nacetylcholine\tO\nrelease\tO\nand\tO\ncholinergic\tO\nconvulsant\tO\nsensitivity\tO\nin\tO\nwithdrawal\tO\nseizure\tB-Disease\n-\tO\nprone\tO\nand\tO\nwithdrawal\tO\nseizure\tB-Disease\n-\tO\nresistant\tO\nselected\tO\nmouse\tO\nlines\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nsepto\tO\n-\tO\nhippocampal\tO\ncholinergic\tO\npathway\tO\nhas\tO\nbeen\tO\nimplicated\tO\nin\tO\nepileptogenesis\tO\n,\tO\nand\tO\ngenetic\tO\nfactors\tO\ninfluence\tO\nthe\tO\nresponse\tO\nto\tO\ncholinergic\tO\nagents\tO\n,\tO\nbut\tO\nlimited\tO\ndata\tO\nare\tO\navailable\tO\non\tO\ncholinergic\tO\ninvolvement\tO\nin\tO\nalcohol\tB-Chemical\nwithdrawal\tO\nseverity\tO\n.\tO\n\nThus\tO\n,\tO\nthe\tO\nrelationship\tO\nbetween\tO\ncholinergic\tO\nactivity\tO\nand\tO\nresponsiveness\tO\nand\tO\nalcohol\tB-Chemical\nwithdrawal\tO\nwas\tO\ninvestigated\tO\nin\tO\na\tO\ngenetic\tO\nanimal\tO\nmodel\tO\nof\tO\nethanol\tB-Chemical\nwithdrawal\tO\nseverity\tO\n.\tO\n\nMETHODS\tO\n:\tO\nCholinergic\tO\nconvulsant\tO\nsensitivity\tO\nwas\tO\nexamined\tO\nin\tO\nalcohol\tB-Chemical\n-\tO\nna\tO\nve\tO\nWithdrawal\tO\nSeizure\tB-Disease\n-\tO\nProne\tO\n(\tO\nWSP\tO\n)\tO\nand\tO\n-\tO\nResistant\tO\n(\tO\nWSR\tO\n)\tO\nmice\tO\n.\tO\n\nAnimals\tO\nwere\tO\nadministered\tO\nnicotine\tB-Chemical\n,\tO\ncarbachol\tB-Chemical\n,\tO\nor\tO\nneostigmine\tB-Chemical\nvia\tO\ntimed\tO\ntail\tO\nvein\tO\ninfusion\tO\n,\tO\nand\tO\nthe\tO\nlatencies\tO\nto\tO\nonset\tO\nof\tO\ntremor\tB-Disease\nand\tO\nclonus\tO\nwere\tO\nrecorded\tO\nand\tO\nconverted\tO\nto\tO\nthreshold\tO\ndose\tO\n.\tO\n\nWe\tO\nalso\tO\nused\tO\nmicrodialysis\tO\nto\tO\nmeasure\tO\nbasal\tO\nand\tO\npotassium\tB-Chemical\n-\tO\nstimulated\tO\nacetylcholine\tB-Chemical\n(\tO\nACh\tB-Chemical\n)\tO\nrelease\tO\nin\tO\nthe\tO\nCA1\tO\nregion\tO\nof\tO\nthe\tO\nhippocampus\tO\n.\tO\n\nPotassium\tB-Chemical\nwas\tO\napplied\tO\nby\tO\nreverse\tO\ndialysis\tO\ntwice\tO\n,\tO\nseparated\tO\nby\tO\n75\tO\nmin\tO\n.\tO\n\nHippocampal\tO\nACh\tB-Chemical\nalso\tO\nwas\tO\nmeasured\tO\nduring\tO\ntesting\tO\nfor\tO\nhandling\tO\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nSensitivity\tO\nto\tO\nseveral\tO\nconvulsion\tB-Disease\nendpoints\tO\ninduced\tO\nby\tO\nnicotine\tB-Chemical\n,\tO\ncarbachol\tB-Chemical\n,\tO\nand\tO\nneostigmine\tB-Chemical\nwere\tO\nsignificantly\tO\ngreater\tO\nin\tO\nWSR\tO\nversus\tO\nWSP\tO\nmice\tO\n.\tO\n\nIn\tO\nmicrodialysis\tO\nexperiments\tO\n,\tO\nthe\tO\nlines\tO\ndid\tO\nnot\tO\ndiffer\tO\nin\tO\nbasal\tO\nrelease\tO\nof\tO\nACh\tB-Chemical\n,\tO\nand\tO\n50\tO\nmM\tO\nKCl\tB-Chemical\nincreased\tO\nACh\tB-Chemical\noutput\tO\nin\tO\nboth\tO\nlines\tO\nof\tO\nmice\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nincrease\tO\nin\tO\nrelease\tO\nof\tO\nACh\tB-Chemical\nproduced\tO\nby\tO\nthe\tO\nfirst\tO\napplication\tO\nof\tO\nKCl\tB-Chemical\nwas\tO\n2\tO\n-\tO\nfold\tO\nhigher\tO\nin\tO\nWSP\tO\nversus\tO\nWSR\tO\nmice\tO\n.\tO\n\nWhen\tO\nhippocampal\tO\nACh\tB-Chemical\nwas\tO\nmeasured\tO\nduring\tO\ntesting\tO\nfor\tO\nhandling\tO\n-\tO\ninduced\tO\nconvulsions\tB-Disease\n,\tO\nextracellular\tO\nACh\tB-Chemical\nwas\tO\nsignificantly\tO\nelevated\tO\n(\tO\n192\tO\n%\tO\n)\tO\nin\tO\nWSP\tO\nmice\tO\n,\tO\nbut\tO\nwas\tO\nnonsignificantly\tO\nelevated\tO\n(\tO\n59\tO\n%\tO\n)\tO\nin\tO\nWSR\tO\nmice\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\ndifferences\tO\nin\tO\ncholinergic\tO\nactivity\tO\nand\tO\npostsynaptic\tO\nsensitivity\tO\nto\tO\ncholinergic\tO\nconvulsants\tB-Disease\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nethanol\tB-Chemical\nwithdrawal\tO\nseverity\tO\nand\tO\nimplicate\tO\ncholinergic\tO\nmechanisms\tO\nin\tO\nalcohol\tB-Chemical\nwithdrawal\tO\n.\tO\n\nSpecifically\tO\n,\tO\nWSP\tO\nmice\tO\nmay\tO\nhave\tO\nlower\tO\nsensitivity\tO\nto\tO\ncholinergic\tO\nconvulsants\tB-Disease\ncompared\tO\nwith\tO\nWSR\tO\nbecause\tO\nof\tO\npostsynaptic\tO\nreceptor\tO\ndesensitization\tO\nbrought\tO\non\tO\nby\tO\nhigher\tO\nactivity\tO\nof\tO\ncholinergic\tO\nneurons\tO\n.\tO\n\nCapsaicin\tB-Chemical\n-\tO\ninduced\tO\nmuscle\tB-Disease\npain\tI-Disease\nalters\tO\nthe\tO\nexcitability\tO\nof\tO\nthe\tO\nhuman\tO\njaw\tO\n-\tO\nstretch\tO\nreflex\tO\n.\tO\n\nThe\tO\npathophysiology\tO\nof\tO\npainful\tO\ntemporomandibular\tB-Disease\ndisorders\tI-Disease\nis\tO\nnot\tO\nfully\tO\nunderstood\tO\n,\tO\nbut\tO\nevidence\tO\nsuggests\tO\nthat\tO\nmuscle\tB-Disease\npain\tI-Disease\nmodulates\tO\nmotor\tO\nfunction\tO\nin\tO\ncharacteristic\tO\nways\tO\n.\tO\n\nCapsaicin\tB-Chemical\n(\tO\n10\tO\nmicro\tO\ng\tO\n)\tO\nwas\tO\ninjected\tO\ninto\tO\nthe\tO\nmasseter\tO\nmuscle\tO\nto\tO\ninduce\tO\npain\tB-Disease\nin\tO\n11\tO\nhealthy\tO\nvolunteers\tO\n.\tO\n\nShort\tO\n-\tO\nlatency\tO\nreflex\tO\nresponses\tO\nwere\tO\nevoked\tO\nin\tO\nthe\tO\nmasseter\tO\nand\tO\ntemporalis\tO\nmuscles\tO\nby\tO\na\tO\nstretch\tO\ndevice\tO\nwith\tO\ndifferent\tO\nvelocities\tO\nand\tO\ndisplacements\tO\nbefore\tO\n,\tO\nduring\tO\n,\tO\nand\tO\nafter\tO\nthe\tO\npain\tB-Disease\n.\tO\n\nThe\tO\nnormalized\tO\nreflex\tO\namplitude\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nduring\tO\npain\tB-Disease\n,\tO\nbut\tO\nonly\tO\nat\tO\nfaster\tO\nstretches\tO\nin\tO\nthe\tO\npainful\tB-Disease\nmuscle\tI-Disease\n.\tO\n\nIncreased\tO\nsensitivity\tO\nof\tO\nthe\tO\nfusimotor\tO\nsystem\tO\nduring\tO\nacute\tO\nmuscle\tB-Disease\npain\tI-Disease\ncould\tO\nbe\tO\none\tO\nlikely\tO\nmechanism\tO\nto\tO\nexplain\tO\nthe\tO\nfindings\tO\n.\tO\n\nEffects\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\naccumbal\tO\nshell\tO\nor\tO\ncore\tO\non\tO\nthe\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nexamine\tO\nthe\tO\neffect\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\nsubregions\tO\nof\tO\nthe\tO\nnucleus\tO\naccumbens\tO\n(\tO\nthe\tO\nshell\tO\nand\tO\nthe\tO\ncore\tO\n)\tO\non\tO\nthe\tO\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\ninduced\tO\nby\tO\ncocaine\tB-Chemical\nin\tO\nrats\tO\n.\tO\n\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\nimplanted\tO\nbilaterally\tO\nwith\tO\ncannulae\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\nor\tO\ncore\tO\n,\tO\nand\tO\nthen\tO\nwere\tO\nlocally\tO\ninjected\tO\nwith\tO\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\nan\tO\nantagonist\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptors\tO\n)\tO\nor\tO\nCP\tB-Chemical\n93129\tI-Chemical\n(\tO\nan\tO\nagonist\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptors\tO\n)\tO\n.\tO\n\nGiven\tO\nalone\tO\nto\tO\nany\tO\naccumbal\tO\nsubregion\tO\n,\tO\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\nor\tO\nCP\tB-Chemical\n93129\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\ndid\tO\nnot\tO\nchange\tO\nbasal\tO\nlocomotor\tO\nactivity\tO\n.\tO\n\nSystemic\tO\ncocaine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nsignificantly\tO\nincreased\tO\nthe\tO\nlocomotor\tO\nactivity\tO\nof\tO\nrats\tO\n.\tO\n\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\n,\tO\nadministered\tO\nintra\tO\n-\tO\naccumbens\tO\nshell\tO\nprior\tO\nto\tO\ncocaine\tB-Chemical\n,\tO\ndose\tO\n-\tO\ndependently\tO\nattenuated\tO\nthe\tO\npsychostimulant\tO\n-\tO\ninduced\tO\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\n.\tO\n\nSuch\tO\nattenuation\tO\nwas\tO\nnot\tO\nfound\tO\nin\tO\nanimals\tO\nwhich\tO\nhad\tO\nbeen\tO\ninjected\tO\nwith\tO\nGR\tB-Chemical\n55562\tI-Chemical\ninto\tO\nthe\tO\naccumbens\tO\ncore\tO\n.\tO\n\nWhen\tO\ninjected\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n(\tO\nbut\tO\nnot\tO\nthe\tO\ncore\tO\n)\tO\nbefore\tO\ncocaine\tB-Chemical\n,\tO\nCP\tB-Chemical\n93129\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\nenhanced\tO\nthe\tO\nlocomotor\tO\nresponse\tO\nto\tO\ncocaine\tB-Chemical\n;\tO\nthe\tO\nmaximum\tO\neffect\tO\nbeing\tO\nobserved\tO\nafter\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\nof\tO\nthe\tO\nagonist\tO\n.\tO\n\nThe\tO\nlater\tO\nenhancement\tO\nwas\tO\nattenuated\tO\nafter\tO\nintra\tO\n-\tO\naccumbens\tO\nshell\tO\ntreatment\tO\nwith\tO\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\n1\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\n.\tO\n\nOur\tO\nfindings\tO\nindicate\tO\nthat\tO\ncocaine\tB-Chemical\ninduced\tO\nhyperlocomotion\tB-Disease\nis\tO\nmodified\tO\nby\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n,\tO\nbut\tO\nnot\tO\ncore\tO\n,\tO\nthis\tO\nmodification\tO\nconsisting\tO\nin\tO\ninhibitory\tO\nand\tO\nfacilitatory\tO\neffects\tO\nof\tO\nthe\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nantagonist\tO\n(\tO\nGR\tB-Chemical\n55562\tI-Chemical\n)\tO\nand\tO\nagonist\tO\n(\tO\nCP\tB-Chemical\n93129\tI-Chemical\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nCocaine\tB-Chemical\nrelated\tO\nchest\tB-Disease\npain\tI-Disease\n:\tO\nare\tO\nwe\tO\nseeing\tO\nthe\tO\ntip\tO\nof\tO\nan\tO\niceberg\tO\n?\tO\n\nThe\tO\nrecreational\tO\nuse\tO\nof\tO\ncocaine\tB-Chemical\nis\tO\non\tO\nthe\tO\nincrease\tO\n.\tO\n\nThe\tO\nemergency\tO\nnurse\tO\nought\tO\nto\tO\nbe\tO\nfamiliar\tO\nwith\tO\nsome\tO\nof\tO\nthe\tO\ncardiovascular\tO\nconsequences\tO\nof\tO\ncocaine\tB-Chemical\nuse\tO\n.\tO\n\nIn\tO\nparticular\tO\n,\tO\nthe\tO\ntendency\tO\nof\tO\ncocaine\tB-Chemical\nto\tO\nproduce\tO\nchest\tB-Disease\npain\tI-Disease\nought\tO\nto\tO\nbe\tO\nin\tO\nthe\tO\nmind\tO\nof\tO\nthe\tO\nemergency\tO\nnurse\tO\nwhen\tO\nfaced\tO\nwith\tO\na\tO\nyoung\tO\nvictim\tO\nof\tO\nchest\tB-Disease\npain\tI-Disease\nwho\tO\nis\tO\notherwise\tO\nat\tO\nlow\tO\nrisk\tO\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\nchest\tB-Disease\npain\tI-Disease\nrelated\tO\nto\tO\ncocaine\tB-Chemical\nuse\tO\nis\tO\ndiscussed\tO\nand\tO\ntreatment\tO\ndilemmas\tO\nare\tO\ndiscussed\tO\n.\tO\n\nFinally\tO\n,\tO\nmoral\tO\nissues\tO\nrelating\tO\nto\tO\nthe\tO\ntesting\tO\nof\tO\npotential\tO\ncocaine\tB-Chemical\nusers\tO\nwill\tO\nbe\tO\naddressed\tO\n.\tO\n\nCrossover\tO\ncomparison\tO\nof\tO\nefficacy\tO\nand\tO\npreference\tO\nfor\tO\nrizatriptan\tB-Chemical\n10\tO\nmg\tO\nversus\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\nin\tO\nmigraine\tB-Disease\n.\tO\n\nRizatriptan\tB-Chemical\nis\tO\na\tO\nselective\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n(\tO\n1B\tO\n/\tO\n1D\tO\n)\tO\nreceptor\tO\nagonist\tO\nwith\tO\nrapid\tO\noral\tO\nabsorption\tO\nand\tO\nearly\tO\nonset\tO\nof\tO\naction\tO\nin\tO\nthe\tO\nacute\tO\ntreatment\tO\nof\tO\nmigraine\tB-Disease\n.\tO\n\nThis\tO\nrandomized\tO\ndouble\tO\n-\tO\nblind\tO\ncrossover\tO\noutpatient\tO\nstudy\tO\nassessed\tO\nthe\tO\npreference\tO\nfor\tO\n1\tO\nrizatriptan\tB-Chemical\n10\tO\nmg\tO\ntablet\tO\nto\tO\n2\tO\nergotamine\tB-Chemical\n1\tO\nmg\tO\n/\tO\ncaffeine\tB-Chemical\n100\tO\nmg\tO\ntablets\tO\nin\tO\n439\tO\npatients\tO\ntreating\tO\na\tO\nsingle\tO\nmigraine\tB-Disease\nattack\tO\nwith\tO\neach\tO\ntherapy\tO\n.\tO\n\nOf\tO\npatients\tO\nexpressing\tO\na\tO\npreference\tO\n(\tO\n89\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nmore\tO\nthan\tO\ntwice\tO\nas\tO\nmany\tO\npreferred\tO\nrizatriptan\tB-Chemical\nto\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\n69\tO\n.\tO\n9\tO\nvs\tO\n.\tO\n30\tO\n.\tO\n1\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nFaster\tO\nrelief\tO\nof\tO\nheadache\tB-Disease\nwas\tO\nthe\tO\nmost\tO\nimportant\tO\nreason\tO\nfor\tO\npreference\tO\n,\tO\ncited\tO\nby\tO\n67\tO\n.\tO\n3\tO\n%\tO\nof\tO\npatients\tO\npreferring\tO\nrizatriptan\tO\nand\tO\n54\tO\n.\tO\n2\tO\n%\tO\nof\tO\npatients\tO\nwho\tO\npreferred\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n.\tO\n\nThe\tO\nco\tO\n-\tO\nprimary\tO\nendpoint\tO\nof\tO\nbeing\tO\npain\tB-Disease\nfree\tO\nat\tO\n2\tO\nh\tO\nwas\tO\nalso\tO\nin\tO\nfavor\tO\nof\tO\nrizatriptan\tO\n.\tO\n\nForty\tO\n-\tO\nnine\tO\npercent\tO\nof\tO\npatients\tO\nwere\tO\npain\tB-Disease\nfree\tO\n2\tO\nh\tO\nafter\tO\nrizatriptan\tB-Chemical\n,\tO\ncompared\tO\nwith\tO\n24\tO\n.\tO\n3\tO\n%\tO\ntreated\tO\nwith\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrizatriptan\tB-Chemical\nbeing\tO\nsuperior\tO\nwithin\tO\n1\tO\nh\tO\nof\tO\ntreatment\tO\n.\tO\n\nHeadache\tB-Disease\nrelief\tO\nat\tO\n2\tO\nh\tO\nwas\tO\n75\tO\n.\tO\n9\tO\n%\tO\nfor\tO\nrizatriptan\tB-Chemical\nand\tO\n47\tO\n.\tO\n3\tO\n%\tO\nfor\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nwith\tO\nrizatriptan\tB-Chemical\nbeing\tO\nsuperior\tO\nto\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\nwithin\tO\n30\tO\nmin\tO\nof\tO\ndosing\tO\n.\tO\n\nAlmost\tO\n36\tO\n%\tO\nof\tO\npatients\tO\ntaking\tO\nrizatriptan\tB-Chemical\nwere\tO\npain\tB-Disease\nfree\tO\nat\tO\n2\tO\nh\tO\nand\tO\nhad\tO\nno\tO\nrecurrence\tO\nor\tO\nneed\tO\nfor\tO\nadditional\tO\nmedication\tO\nwithin\tO\n24\tO\nh\tO\n,\tO\ncompared\tO\nto\tO\n20\tO\n%\tO\nof\tO\npatients\tO\non\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRizatriptan\tB-Chemical\nwas\tO\nalso\tO\nsuperior\tO\nto\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\nin\tO\nthe\tO\nproportions\tO\nof\tO\npatients\tO\nwith\tO\nno\tO\nnausea\tB-Disease\n,\tO\nvomiting\tO\n,\tO\nphonophobia\tB-Disease\nor\tO\nphotophobia\tB-Disease\nand\tO\nfor\tO\npatients\tO\nwith\tO\nnormal\tO\nfunction\tO\n2\tO\nh\tO\nafter\tO\ndrug\tO\nintake\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nMore\tO\npatients\tO\nwere\tO\n(\tO\ncompletely\tO\n,\tO\nvery\tO\nor\tO\nsomewhat\tO\n)\tO\nsatisfied\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tO\nwith\tO\nrizatriptan\tB-Chemical\n(\tO\n69\tO\n.\tO\n8\tO\n%\tO\n)\tO\nthan\tO\nat\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tO\nwith\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n(\tO\n38\tO\n.\tO\n6\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRecurrence\tO\nrates\tO\nwere\tO\n31\tO\n.\tO\n4\tO\n%\tO\nwith\tO\nrizatriptan\tB-Chemical\nand\tO\n15\tO\n.\tO\n3\tO\n%\tO\nwith\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tO\nevents\tO\n(\tO\nincidence\tO\n>\tO\nor\tO\n=\tO\n5\tO\n%\tO\nin\tO\none\tO\ngroup\tO\n)\tO\nafter\tO\nrizatriptan\tB-Chemical\nand\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tB-Chemical\n,\tO\nrespectively\tO\n,\tO\nwere\tO\ndizziness\tB-Disease\n(\tO\n6\tO\n.\tO\n7\tO\nand\tO\n5\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nnausea\tB-Disease\n(\tO\n4\tO\n.\tO\n2\tO\nand\tO\n8\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\nsomnolence\tB-Disease\n(\tO\n5\tO\n.\tO\n5\tO\nand\tO\n2\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nSevere\tO\nocular\tB-Disease\nand\tI-Disease\norbital\tI-Disease\ntoxicity\tI-Disease\nafter\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tB-Chemical\nfor\tO\nrecurrent\tO\nglioblastomas\tB-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nGlioblastoma\tB-Disease\nis\tO\na\tO\nmalignant\tB-Disease\ntumor\tI-Disease\nthat\tO\noccurs\tO\nin\tO\nthe\tO\ncerebrum\tO\nduring\tO\nadulthood\tO\n.\tO\n\nTherefore\tO\n,\tO\npatients\tO\nwith\tO\nglioblastoma\tB-Disease\nsometimes\tO\nhave\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarcinostatics\tO\nadded\tO\nto\tO\nthe\tO\ntreatment\tO\nregimen\tO\n.\tO\n\nGenerally\tO\n,\tO\ncarboplatin\tB-Chemical\nis\tO\nsaid\tO\nto\tO\nhave\tO\nmilder\tO\nside\tO\neffects\tO\nthan\tO\ncisplatin\tO\n,\tO\nwhose\tO\nocular\tB-Disease\nand\tI-Disease\norbital\tI-Disease\ntoxicity\tI-Disease\nare\tO\nwell\tO\nknown\tO\n.\tO\n\nHowever\tO\n,\tO\nwe\tO\nexperienced\tO\na\tO\ncase\tO\nof\tO\nsevere\tO\nocular\tB-Disease\nand\tI-Disease\norbital\tI-Disease\ntoxicity\tI-Disease\nafter\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tB-Chemical\n,\tO\nwhich\tO\nis\tO\ninfrequently\tO\nreported\tO\n.\tO\n\nCASE\tO\n:\tO\nA\tO\n58\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nreceived\tO\nan\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tB-Chemical\nfor\tO\nrecurrent\tO\nglioblastomas\tB-Disease\nin\tO\nhis\tO\nleft\tO\ntemporal\tO\nlobe\tO\n.\tO\n\nHe\tO\ncomplained\tO\nof\tO\npain\tB-Disease\nand\tI-Disease\nvisual\tI-Disease\ndisturbance\tI-Disease\nin\tI-Disease\nthe\tI-Disease\nipsilateral\tI-Disease\neye\tI-Disease\n30\tO\nh\tO\nafter\tO\nthe\tO\ninjection\tO\n.\tO\n\nVarious\tO\nocular\tO\nsymptoms\tO\nand\tO\nfindings\tO\ncaused\tO\nby\tO\ncarboplatin\tB-Chemical\ntoxicity\tB-Disease\nwere\tO\nseen\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHe\tO\nwas\tO\ntreated\tO\nwith\tO\nintravenous\tO\nadministration\tO\nof\tO\ncorticosteroids\tO\nand\tO\nglycerin\tB-Chemical\nfor\tO\n6\tO\ndays\tO\nafter\tO\nthe\tO\ninjection\tO\n.\tO\n\nAlthough\tO\nthe\tO\nintraocular\tO\npressure\tO\nelevation\tO\ncaused\tO\nby\tO\nsecondary\tO\nacute\tO\nangle\tO\n-\tO\nclosure\tO\nglaucoma\tB-Disease\ndecreased\tO\nand\tO\nocular\tB-Disease\npain\tI-Disease\ndiminished\tO\n,\tO\ninexorable\tO\npapilledema\tB-Disease\nand\tO\nexudative\tO\nretinal\tB-Disease\ndetachment\tI-Disease\ncontinued\tO\nfor\tO\n3\tO\nweeks\tO\n.\tO\n\nFinally\tO\n,\tO\n6\tO\nweeks\tO\nlater\tO\n,\tO\ndiffuse\tO\nchorioretinal\tB-Disease\natrophy\tI-Disease\nwith\tO\noptic\tB-Disease\natrophy\tI-Disease\noccurred\tO\nand\tO\nthe\tO\nvision\tO\nin\tO\nhis\tO\nleft\tO\neye\tO\nwas\tO\nlost\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nWhen\tO\nperforming\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tB-Chemical\n,\tO\nwe\tO\nmust\tO\nbe\tO\naware\tO\nof\tO\nits\tO\npotentially\tO\nblinding\tO\nocular\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nVisual\tO\nhallucinations\tO\nassociated\tO\nwith\tO\nzonisamide\tB-Chemical\n.\tO\n\nZonisamide\tB-Chemical\nis\tO\na\tO\nbroad\tO\n-\tO\nspectrum\tO\nantiepileptic\tO\ndrug\tO\nused\tO\nto\tO\ntreat\tO\nvarious\tO\ntypes\tO\nof\tO\nseizures\tB-Disease\n.\tO\n\nAlthough\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\nhave\tO\nnot\tO\nbeen\tO\nreported\tO\nas\tO\nan\tO\nadverse\tO\neffect\tO\nof\tO\nthis\tO\nagent\tO\n,\tO\nwe\tO\ndescribe\tO\nthree\tO\npatients\tO\nwho\tO\nexperienced\tO\ncomplex\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\nand\tO\naltered\tO\nmental\tO\nstatus\tO\nafter\tO\nzonisamide\tB-Chemical\ntreatment\tO\nwas\tO\nbegun\tO\nor\tO\nits\tO\ndosage\tO\nincreased\tO\n.\tO\n\nAll\tO\nthree\tO\nhad\tO\nbeen\tO\ndiagnosed\tO\nearlier\tO\nwith\tO\nepilepsy\tB-Disease\n,\tO\nand\tO\ntheir\tO\nelectroencephalogram\tO\n(\tO\nEEG\tO\n)\tO\nfindings\tO\nwere\tO\nabnormal\tO\n.\tO\n\nDuring\tO\nmonitoring\tO\n,\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nEEG\tO\nreadings\tO\n,\tO\nnor\tO\ndid\tO\nvideo\tO\nrecording\tO\ncapture\tO\nany\tO\nof\tO\nthe\tO\ndescribed\tO\nevents\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\npatients\tO\nhad\tO\nexperienced\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\nbefore\tO\nthis\tO\nevent\tO\n.\tO\n\nThe\tO\nonly\tO\nrecent\tO\nchange\tO\nin\tO\ntheir\tO\ntreatment\tO\nwas\tO\nthe\tO\nintroduction\tO\nor\tO\nincreased\tO\ndosage\tO\nof\tO\nzonisamide\tB-Chemical\n.\tO\n\nUntil\tO\nthen\tO\n,\tO\nclinicians\tO\nneed\tO\nto\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\npossible\tO\ncomplication\tO\nassociated\tO\nwith\tO\nzonisamide\tB-Chemical\n.\tO\n\nAnti\tO\n-\tO\nepileptic\tB-Disease\ndrugs\tO\n-\tO\ninduced\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizures\tI-Disease\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\nthree\tO\npatients\tO\nwith\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nepilepsy\tI-Disease\nafter\tO\nadministration\tO\nof\tO\ncarbamazepine\tB-Chemical\nand\tO\nvigabatrin\tB-Chemical\n.\tO\n\nDespite\tO\nthe\tO\nunderlying\tO\ndiseases\tO\n,\tO\nthe\tO\nprognosis\tO\nfor\tO\ndrug\tO\n-\tO\ninduced\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizure\tI-Disease\nis\tO\ngood\tO\nbecause\tO\nit\tO\nsubsides\tO\nrapidly\tO\nafter\tO\ndiscontinuing\tO\nthe\tO\nuse\tO\nof\tO\nthe\tO\noffending\tO\ndrugs\tO\n.\tO\n\nThe\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n-\tO\ntransmitted\tO\nthalamocortical\tO\ncircuitry\tO\naccounts\tO\nfor\tO\na\tO\nmajor\tO\npart\tO\nof\tO\nthe\tO\nunderlying\tO\nneurophysiology\tO\nof\tO\nthe\tO\nabsence\tB-Disease\nepilepsy\tI-Disease\n.\tO\n\nBecause\tO\ndrug\tO\n-\tO\ninduced\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizure\tI-Disease\nis\tO\nrare\tO\n,\tO\npro\tO\n-\tO\nabsence\tO\ndrugs\tO\ncan\tO\nonly\tO\nbe\tO\nconsidered\tO\na\tO\npromoting\tO\nfactor\tO\n.\tO\n\nThe\tO\nunderlying\tO\nepileptogenecity\tO\nof\tO\nthe\tO\npatients\tO\nor\tO\nthe\tO\nsynergistic\tO\neffects\tO\nof\tO\nthe\tO\naccompanying\tO\ndrugs\tO\nis\tO\nrequired\tO\nto\tO\ntrigger\tO\nthe\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizure\tI-Disease\n.\tO\n\nThe\tO\npossibility\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\naggravation\tO\nshould\tO\nbe\tO\nconsidered\tO\nwhenever\tO\nan\tO\nunexpected\tO\nincrease\tO\nin\tO\nseizure\tB-Disease\nfrequency\tO\nand\tO\n/\tO\nor\tO\nnew\tO\nseizure\tB-Disease\ntypes\tO\nappear\tO\nfollowing\tO\na\tO\nchange\tO\nin\tO\ndrug\tO\ntreatment\tO\n.\tO\n\nBy\tO\nunderstanding\tO\nthe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nabsence\tB-Disease\nepilepsy\tI-Disease\n,\tO\nwe\tO\ncan\tO\navoid\tO\nthe\tO\ninappropriate\tO\nuse\tO\nof\tO\nanticonvulsants\tO\nin\tO\nchildren\tO\nwith\tO\nepilepsy\tB-Disease\nand\tO\nprevent\tO\ndrug\tO\n-\tO\ninduced\tO\nabsence\tB-Disease\nseizures\tI-Disease\n.\tO\n\nPrenatal\tO\ndexamethasone\tO\nprograms\tO\nhypertension\tB-Disease\nand\tO\nrenal\tB-Disease\ninjury\tI-Disease\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nif\tO\nprenatal\tO\ndexamethasone\tB-Chemical\nprogrammed\tO\na\tO\nprogressive\tO\nincrease\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nand\tO\nrenal\tB-Disease\ninjury\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nPregnant\tO\nrats\tO\nwere\tO\ngiven\tO\neither\tO\nvehicle\tO\nor\tO\n2\tO\ndaily\tO\nintraperitoneal\tO\ninjections\tO\nof\tO\ndexamethasone\tB-Chemical\n(\tO\n0\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n)\tO\non\tO\ngestational\tO\ndays\tO\n11\tO\nand\tO\n12\tO\n,\tO\n13\tO\nand\tO\n14\tO\n,\tO\n15\tO\nand\tO\n16\tO\n,\tO\n17\tO\nand\tO\n18\tO\n,\tO\nor\tO\n19\tO\nand\tO\n20\tO\n.\tO\n\nOffspring\tO\nof\tO\nrats\tO\nadministered\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\ngestation\tO\nhad\tO\na\tO\n20\tO\n%\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\ncompared\tO\nwith\tO\ncontrol\tO\nat\tO\n6\tO\nto\tO\n9\tO\nmonths\tO\nof\tO\nage\tO\n(\tO\n22\tO\n527\tO\n+\tO\n/\tO\n-\tO\n509\tO\nversus\tO\n28\tO\n050\tO\n+\tO\n/\tO\n-\tO\n561\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nwhich\tO\nwas\tO\ncomparable\tO\nto\tO\nthe\tO\npercent\tO\nreduction\tO\nin\tO\nglomeruli\tO\nmeasured\tO\nat\tO\n3\tO\nweeks\tO\nof\tO\nage\tO\n.\tO\n\nSix\tO\n-\tO\nto\tO\n9\tO\n-\tO\nmonth\tO\nold\tO\nrats\tO\nreceiving\tO\nprenatal\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n17\tO\nand\tO\n18\tO\nof\tO\ngestation\tO\nhad\tO\na\tO\n17\tO\n%\tO\nreduction\tO\nin\tO\nglomeruli\tO\n(\tO\n23\tO\n380\tO\n+\tO\n/\tO\n-\tO\n587\tO\n)\tO\ncompared\tO\nwith\tO\ncontrol\tO\nrats\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nMale\tO\nrats\tO\nthat\tO\nreceived\tO\nprenatal\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\n,\tO\n17\tO\nand\tO\n18\tO\n,\tO\nand\tO\n13\tO\nand\tO\n14\tO\nof\tO\ngestation\tO\nhad\tO\nelevated\tO\nblood\tO\npressures\tO\nat\tO\n6\tO\nmonths\tO\nof\tO\nage\tO\n;\tO\nthe\tO\nlatter\tO\ngroup\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\n.\tO\n\nAdult\tO\nrats\tO\ngiven\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\nof\tO\ngestation\tO\nhad\tO\nmore\tO\nglomeruli\tO\nwith\tO\nglomerulosclerosis\tB-Disease\nthan\tO\ncontrol\tO\nrats\tO\n.\tO\n\nThis\tO\nstudy\tO\nshows\tO\nthat\tO\nprenatal\tO\ndexamethasone\tB-Chemical\nin\tO\nrats\tO\nresults\tO\nin\tO\na\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\n,\tO\nglomerulosclerosis\tB-Disease\n,\tO\nand\tO\nhypertension\tB-Disease\nwhen\tO\nadministered\tO\nat\tO\nspecific\tO\npoints\tO\nduring\tO\ngestation\tO\n.\tO\n\nHypertension\tB-Disease\nwas\tO\nobserved\tO\nin\tO\nanimals\tO\nthat\tO\nhad\tO\na\tO\nreduction\tO\nin\tO\nglomeruli\tO\nas\tO\nwell\tO\nas\tO\nin\tO\na\tO\ngroup\tO\nthat\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\n,\tO\nsuggesting\tO\nthat\tO\na\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\nis\tO\nnot\tO\nthe\tO\nsole\tO\ncause\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nhypertension\tB-Disease\n.\tO\n\nKidney\tO\nfunction\tO\nand\tO\nmorphology\tO\nafter\tO\nshort\tO\n-\tO\nterm\tO\ncombination\tO\ntherapy\tO\nwith\tO\ncyclosporine\tB-Chemical\nA\tI-Chemical\n,\tO\ntacrolimus\tB-Chemical\nand\tO\nsirolimus\tB-Chemical\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nSirolimus\tB-Chemical\n(\tO\nSRL\tB-Chemical\n)\tO\nmay\tO\nsupplement\tO\ncalcineurin\tO\ninhibitors\tO\nin\tO\nclinical\tO\norgan\tO\ntransplantation\tO\n.\tO\n\nThese\tO\nare\tO\nnephrotoxic\tB-Disease\n,\tO\nbut\tO\nSRL\tB-Chemical\nseems\tO\nto\tO\nact\tO\ndifferently\tO\ndisplaying\tO\nonly\tO\nminor\tO\nnephrotoxic\tB-Disease\neffects\tO\n,\tO\nalthough\tO\nthis\tO\nquestion\tO\nis\tO\nstill\tO\nopen\tO\n.\tO\n\nIn\tO\na\tO\nnumber\tO\nof\tO\ntreatment\tO\nprotocols\tO\nwhere\tO\nSRL\tB-Chemical\nwas\tO\ncombined\tO\nwith\tO\na\tO\ncalcineurin\tO\ninhibitor\tO\nindications\tO\nof\tO\na\tO\nsynergistic\tO\nnephrotoxic\tB-Disease\neffect\tO\nwere\tO\ndescribed\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nfurther\tO\nthe\tO\nrenal\tO\nfunction\tO\n,\tO\nincluding\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nof\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tO\nwith\tO\neither\tO\ncyclosporine\tB-Chemical\nA\tI-Chemical\n(\tO\nCsA\tB-Chemical\n)\tO\n,\tO\ntacrolimus\tB-Chemical\n(\tO\nFK506\tB-Chemical\n)\tO\nor\tO\nSRL\tO\nas\tO\nmonotherapies\tO\nor\tO\nin\tO\ndifferent\tO\ncombinations\tO\n.\tO\n\nMETHODS\tO\n:\tO\nFor\tO\na\tO\nperiod\tO\nof\tO\n2\tO\nweeks\tO\n,\tO\nCsA\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\norally\tO\n)\tO\n,\tO\nFK506\tB-Chemical\n3\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\norally\tO\n)\tO\nor\tO\nSRL\tB-Chemical\n0\tO\n.\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\nintraperitoneally\tO\n)\tO\nwas\tO\nadministered\tO\nonce\tO\na\tO\nday\tO\nas\tO\nthese\tO\ndoses\tO\nhave\tO\nearlier\tO\nbeen\tO\nfound\tO\nto\tO\nachieve\tO\na\tO\nsignificant\tO\nimmunosuppressive\tO\neffect\tO\nin\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\n.\tO\n\nThe\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nincluded\tO\na\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nsystem\tO\nanalysing\tO\nthe\tO\ndegree\tO\nof\tO\nstriped\tO\nfibrosis\tB-Disease\n,\tO\nsubcapsular\tO\nfibrosis\tB-Disease\nand\tO\nthe\tO\nnumber\tO\nof\tO\nbasophilic\tO\ntubules\tO\n,\tO\nplus\tO\nan\tO\nadditional\tO\nstereological\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tO\ngrade\tO\nof\tO\nfibrosis\tB-Disease\nin\tO\nthe\tO\ncortex\tO\nstained\tO\nwith\tO\nSirius\tO\nRed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nCsA\tB-Chemical\n,\tO\nFK506\tB-Chemical\nand\tO\nSRL\tB-Chemical\nall\tO\nsignificantly\tO\ndecreased\tO\nthe\tO\nGFR\tO\n.\tO\n\nA\tO\nfurther\tO\ndeterioration\tO\nwas\tO\nseen\tO\nwhen\tO\nCsA\tB-Chemical\nwas\tO\ncombined\tO\nwith\tO\neither\tO\nFK506\tB-Chemical\nor\tO\nSRL\tB-Chemical\n,\tO\nwhereas\tO\nthe\tO\nGFR\tO\nremained\tO\nunchanged\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nFK506\tB-Chemical\nplus\tO\nSRL\tB-Chemical\nwhen\tO\ncompared\tO\nwith\tO\ntreatment\tO\nwith\tO\nany\tO\nof\tO\nthe\tO\nsingle\tO\nsubstances\tO\n.\tO\n\nThe\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nwas\tO\nsignificantly\tO\nworst\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nCsA\tB-Chemical\nplus\tO\nSRL\tB-Chemical\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\ncompared\tO\nwith\tO\ncontrols\tO\n)\tO\nand\tO\nthe\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tO\ngrade\tO\nof\tO\nfibrosis\tB-Disease\nalso\tO\nshowed\tO\nthe\tO\nhighest\tO\nproportion\tO\nin\tO\nthe\tO\nsame\tO\ngroup\tO\nand\tO\nwas\tO\nsignificantly\tO\ndifferent\tO\nfrom\tO\ncontrols\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nThe\tO\nFK506\tB-Chemical\nplus\tO\nSRL\tB-Chemical\ncombination\tO\nshowed\tO\nonly\tO\na\tO\nmarginally\tO\nhigher\tO\ndegree\tO\nof\tO\nfibrosis\tB-Disease\nas\tO\ncompared\tO\nwith\tO\ncontrols\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nrat\tO\nstudy\tO\ndemonstrated\tO\na\tO\nsynergistic\tO\nnephrotoxic\tB-Disease\neffect\tO\nof\tO\nCsA\tB-Chemical\nplus\tO\nSRL\tB-Chemical\n,\tO\nwhereas\tO\nFK506\tB-Chemical\nplus\tO\nSRL\tB-Chemical\nwas\tO\nbetter\tO\ntolerated\tO\n.\tO\n\nEvaluation\tO\nof\tO\ncardiac\tO\ntroponin\tO\nI\tO\nand\tO\nT\tO\nlevels\tO\nas\tO\nmarkers\tO\nof\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nin\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\nrats\tO\n,\tO\nand\tO\ntheir\tO\nrelationship\tO\nwith\tO\nechocardiographic\tO\nand\tO\nhistological\tO\nfindings\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCardiac\tO\ntroponins\tO\nI\tO\n(\tO\ncTnI\tO\n)\tO\nand\tO\nT\tO\n(\tO\ncTnT\tO\n)\tO\nhave\tO\nbeen\tO\nshown\tO\nto\tO\nbe\tO\nhighly\tO\nsensitive\tO\nand\tO\nspecific\tO\nmarkers\tO\nof\tO\nmyocardial\tB-Disease\ncell\tI-Disease\ninjury\tI-Disease\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\ndiagnostic\tO\nvalue\tO\nof\tO\ncTnI\tO\nand\tO\ncTnT\tO\nfor\tO\nthe\tO\ndiagnosis\tO\nof\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\ndoxorubicin\tB-Chemical\n(\tO\nDOX\tB-Chemical\n)\tO\n-\tO\ninduced\tO\ncardiomyopathy\tB-Disease\n,\tO\nand\tO\nwe\tO\nexamined\tO\nthe\tO\nrelationship\tO\nbetween\tO\nserial\tO\ncTnI\tO\nand\tO\ncTnT\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\ncardiac\tB-Disease\ndisorders\tI-Disease\nmonitored\tO\nby\tO\nechocardiography\tO\nand\tO\nhistological\tO\nexaminations\tO\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThirty\tO\n-\tO\nfive\tO\nWistar\tO\nrats\tO\nwere\tO\ngiven\tO\n1\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nDOX\tB-Chemical\n,\tO\ni\tO\n.\tO\nv\tO\n.\tO\n,\tO\nweekly\tO\nfor\tO\nup\tO\nto\tO\n8\tO\nweeks\tO\nfor\tO\na\tO\ntotal\tO\ncumulative\tO\ndose\tO\nof\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n.\tO\n\nBy\tO\nusing\tO\ntransthoracic\tO\nechocardiography\tO\n,\tO\nanterior\tO\nand\tO\nposterior\tO\nwall\tO\nthickness\tO\n,\tO\nLV\tO\ndiameters\tO\nand\tO\nLV\tO\nfractional\tO\nshortening\tO\n(\tO\nFS\tO\n)\tO\nwere\tO\nmeasured\tO\nin\tO\nall\tO\nrats\tO\nbefore\tO\nDOX\tB-Chemical\nor\tO\nsaline\tO\n,\tO\nand\tO\nat\tO\nweeks\tO\n6\tO\nand\tO\n9\tO\nafter\tO\ntreatment\tO\nin\tO\nall\tO\nsurviving\tO\nrats\tO\n.\tO\n\nHistology\tO\nwas\tO\nperformed\tO\nin\tO\nDOX\tO\n-\tO\nrats\tO\nat\tO\n6\tO\nand\tO\n9\tO\nweeks\tO\nafter\tO\nthe\tO\nlast\tO\nDOX\tB-Chemical\ndose\tO\nand\tO\nin\tO\nall\tO\ncontrols\tO\n.\tO\n\nRESULTS\tO\n:\tO\nEighteen\tO\nof\tO\nthe\tO\nDOX\tB-Chemical\nrats\tO\ndied\tO\nprematurely\tO\nof\tO\ngeneral\tO\ntoxicity\tB-Disease\nduring\tO\nthe\tO\n9\tO\n-\tO\nweek\tO\nperiod\tO\n.\tO\n\nEnd\tO\n-\tO\ndiastolic\tO\n(\tO\nED\tO\n)\tO\nand\tO\nend\tO\n-\tO\nsystolic\tO\n(\tO\nES\tO\n)\tO\nLV\tO\ndiameters\tO\n/\tO\nBW\tO\nsignificantly\tO\nincreased\tO\n,\tO\nwhereas\tO\nLV\tO\nFS\tO\nwas\tO\ndecreased\tO\nafter\tO\n9\tO\nweeks\tO\nin\tO\nthe\tO\nDOX\tB-Chemical\ngroup\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nHistological\tO\nevaluation\tO\nof\tO\nhearts\tO\nfrom\tO\nall\tO\nrats\tO\ngiven\tO\nDOX\tB-Chemical\nrevealed\tO\nsignificant\tO\nslight\tO\ndegrees\tO\nof\tO\nperivascular\tO\nand\tO\ninterstitial\tO\nfibrosis\tB-Disease\n.\tO\n\nOnly\tO\nfive\tO\nof\tO\nthe\tO\ncontrols\tO\nexhibited\tO\nevidence\tO\nof\tO\nvery\tO\nslight\tO\nperivascular\tO\nfibrosis\tB-Disease\n.\tO\n\nA\tO\nsignificant\tO\nrise\tO\nin\tO\ncTnT\tO\nwas\tO\nfound\tO\nin\tO\nDOX\tB-Chemical\nrats\tO\nafter\tO\ncumulative\tO\ndoses\tO\nof\tO\n7\tO\n.\tO\n5\tO\nand\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nin\tO\ncomparison\tO\nwith\tO\nbaseline\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\ncTnT\tO\nfound\tO\nin\tO\nrats\tO\nafter\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nwere\tO\nsignificantly\tO\ngreater\tO\nthan\tO\nthat\tO\nfound\tO\nafter\tO\n7\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nDOX\tB-Chemical\n.\tO\n\nMaximal\tO\ncTnI\tO\n(\tO\npg\tO\n/\tO\nml\tO\n)\tO\nand\tO\ncTnT\tO\nlevels\tO\nwere\tO\nsignificantly\tO\nincreased\tO\nin\tO\nDOX\tB-Chemical\nrats\tO\ncompared\tO\nwith\tO\ncontrols\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n006\tO\n,\tO\n0\tO\n.\tO\n007\tO\n)\tO\n.\tO\n\ncTnI\tO\n(\tO\nng\tO\n/\tO\nml\tO\n)\tO\n,\tO\nCK\tO\n-\tO\nMB\tO\nmass\tO\nand\tO\nCK\tO\nremained\tO\nunchanged\tO\nin\tO\nDOX\tB-Chemical\nrats\tO\ncompared\tO\nwith\tO\ncontrols\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAmong\tO\nmarkers\tO\nof\tO\nischemic\tB-Disease\ninjury\tI-Disease\nafter\tO\nDOX\tB-Chemical\nin\tO\nrats\tO\n,\tO\ncTnT\tO\nshowed\tO\nthe\tO\ngreatest\tO\nability\tO\nto\tO\ndetect\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nassessed\tO\nby\tO\nechocardiographic\tO\ndetection\tO\nand\tO\nhistological\tO\nchanges\tO\n.\tO\n\nAlthough\tO\nthere\tO\nwas\tO\na\tO\ndiscrepancy\tO\nbetween\tO\nthe\tO\namount\tO\nof\tO\ncTnI\tO\nand\tO\ncTnT\tO\nafter\tO\nDOX\tB-Chemical\n,\tO\nprobably\tO\ndue\tO\nto\tO\nheterogeneity\tO\nin\tO\ncross\tO\n-\tO\nreactivities\tO\nof\tO\nmAbs\tO\nto\tO\nvarious\tO\ncTnI\tO\nand\tO\ncTnT\tO\nforms\tO\n,\tO\nit\tO\nis\tO\nlikely\tO\nthat\tO\ncTnT\tO\nin\tO\nrats\tO\nafter\tO\nDOX\tB-Chemical\nindicates\tO\ncell\tO\ndamage\tO\ndetermined\tO\nby\tO\nthe\tO\nmagnitude\tO\nof\tO\ninjury\tO\ninduced\tO\nand\tO\nthat\tO\ncTnT\tO\nshould\tO\nbe\tO\na\tO\nuseful\tO\nmarker\tO\nfor\tO\nthe\tO\nprediction\tO\nof\tO\nexperimentally\tO\ninduced\tO\ncardiotoxicity\tB-Disease\nand\tO\npossibly\tO\nfor\tO\ncardioprotective\tO\nexperiments\tO\n.\tO\n\nOctreotide\tB-Chemical\n-\tO\ninduced\tO\nhypoxemia\tB-Disease\nand\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nin\tO\npremature\tO\nneonates\tO\n.\tO\n\nThe\tO\nauthors\tO\nreport\tO\n2\tO\ncases\tO\nof\tO\npremature\tO\nneonates\tO\nwho\tO\nhad\tO\nenterocutaneous\tO\nfistula\tB-Disease\ncomplicating\tO\nnecrotizing\tB-Disease\nenterocolitis\tI-Disease\n.\tO\n\nPulmonary\tB-Disease\nhypertension\tI-Disease\ndeveloped\tO\nafter\tO\nadministration\tO\nof\tO\na\tO\nsomatostatin\tO\nanalogue\tO\n,\tO\noctreotide\tB-Chemical\n,\tO\nto\tO\nenhance\tO\nresolution\tO\nof\tO\nthe\tO\nfistula\tB-Disease\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\nin\tO\nwomen\tO\nprescribed\tO\ncyproterone\tB-Chemical\nacetate\tI-Chemical\nin\tO\ncombination\tO\nwith\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n:\tO\na\tO\nnested\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tB-Chemical\nacetate\tI-Chemical\ncombined\tO\nwith\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n(\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\n)\tO\nis\tO\nlicensed\tO\nin\tO\nthe\tO\nUK\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nwomen\tO\nwith\tO\nacne\tB-Disease\nand\tO\nhirsutism\tB-Disease\nand\tO\nis\tO\nalso\tO\na\tO\ntreatment\tO\noption\tO\nfor\tO\npolycystic\tB-Disease\novary\tI-Disease\nsyndrome\tI-Disease\n(\tO\nPCOS\tB-Disease\n)\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tB-Disease\n)\tO\nassociated\tO\nwith\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\ncompared\tO\nwith\tO\nconventional\tO\ncombined\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n(\tO\nCOCs\tO\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nthe\tO\nGeneral\tO\nPractice\tO\nResearch\tO\nDatabase\tO\nwe\tO\nconducted\tO\na\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nnested\tO\nwithin\tO\na\tO\npopulation\tO\nof\tO\nwomen\tO\naged\tO\nbetween\tO\n15\tO\nand\tO\n39\tO\nyears\tO\nwith\tO\nacne\tB-Disease\n,\tO\nhirsutism\tB-Disease\nor\tO\nPCOS\tB-Disease\nto\tO\nestimate\tO\nthe\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nassociated\tO\nwith\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nage\tO\n-\tO\nadjusted\tO\nincidence\tO\nrate\tO\nratio\tO\nfor\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\nversus\tO\nconventional\tO\nCOCs\tO\nwas\tO\n2\tO\n.\tO\n20\tO\n[\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n(\tO\nCI\tO\n)\tO\n1\tO\n.\tO\n35\tO\n-\tO\n3\tO\n.\tO\n58\tO\n]\tO\n.\tO\n\nUsing\tO\nas\tO\nthe\tO\nreference\tO\ngroup\tO\nwomen\tO\nwho\tO\nwere\tO\nnot\tO\nusing\tO\noral\tO\ncontraception\tO\n,\tO\nhad\tO\nno\tO\nrecent\tO\npregnancy\tO\nor\tO\nmenopausal\tO\nsymptoms\tO\n,\tO\nthe\tO\ncase\tO\n-\tO\ncontrol\tO\nanalysis\tO\ngave\tO\nan\tO\nadjusted\tO\nodds\tO\nratio\tO\n(\tO\nOR\tO\n(\tO\nadj\tO\n)\tO\n)\tO\nof\tO\n7\tO\n.\tO\n44\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n3\tO\n.\tO\n67\tO\n-\tO\n15\tO\n.\tO\n08\tO\n)\tO\nfor\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\nuse\tO\ncompared\tO\nwith\tO\nan\tO\nOR\tO\n(\tO\nadj\tO\n)\tO\nof\tO\n2\tO\n.\tO\n58\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n60\tO\n-\tO\n4\tO\n.\tO\n18\tO\n)\tO\nfor\tO\nuse\tO\nof\tO\nconventional\tO\nCOCs\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nVTE\tB-Disease\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nCPA\tB-Chemical\n/\tO\nEE\tB-Chemical\nin\tO\nwomen\tO\nwith\tO\nacne\tB-Disease\n,\tO\nhirsutism\tB-Disease\nor\tO\nPCOS\tB-Disease\nalthough\tO\nresidual\tO\nconfounding\tO\nby\tO\nindication\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\ntreatment\tO\nwith\tO\ngum\tB-Chemical\nArabic\tI-Chemical\non\tO\ngentamicin\tB-Chemical\nnephrotoxicity\tB-Disease\nin\tO\nrats\tO\n:\tO\na\tO\npreliminary\tO\nstudy\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nwork\tO\nwe\tO\nassessed\tO\nthe\tO\neffect\tO\nof\tO\ntreatment\tO\nof\tO\nrats\tO\nwith\tO\ngum\tB-Chemical\nArabic\tI-Chemical\non\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\ninduced\tO\nby\tO\ngentamicin\tB-Chemical\n(\tO\nGM\tB-Chemical\n)\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nRats\tO\nwere\tO\ntreated\tO\nwith\tO\nthe\tO\nvehicle\tO\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\ndistilled\tO\nwater\tO\nand\tO\n5\tO\n%\tO\nw\tO\n/\tO\nv\tO\ncellulose\tO\n,\tO\n10\tO\ndays\tO\n)\tO\n,\tO\ngum\tB-Chemical\nArabic\tI-Chemical\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\na\tO\n10\tO\n%\tO\nw\tO\n/\tO\nv\tO\naqueous\tO\nsuspension\tO\nof\tO\ngum\tB-Chemical\nArabic\tI-Chemical\npowder\tO\n,\tO\norally\tO\nfor\tO\n10\tO\ndays\tO\n)\tO\n,\tO\nor\tO\ngum\tB-Chemical\nArabic\tI-Chemical\nconcomitantly\tO\nwith\tO\nGM\tB-Chemical\n(\tO\n80mg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nintramuscularly\tO\n,\tO\nduring\tO\nthe\tO\nlast\tO\nsix\tO\ndays\tO\nof\tO\nthe\tO\ntreatment\tO\nperiod\tO\n)\tO\n.\tO\n\nNephrotoxicity\tB-Disease\nwas\tO\nassessed\tO\nby\tO\nmeasuring\tO\nthe\tO\nconcentrations\tO\nof\tO\ncreatinine\tB-Chemical\nand\tO\nurea\tB-Chemical\nin\tO\nthe\tO\nplasma\tO\nand\tO\nreduced\tO\nglutathione\tB-Chemical\n(\tO\nGSH\tB-Chemical\n)\tO\nin\tO\nthe\tO\nkidney\tO\ncortex\tO\n,\tO\nand\tO\nby\tO\nlight\tO\nmicroscopic\tO\nexamination\tO\nof\tO\nkidney\tO\nsections\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ngum\tB-Chemical\nArabic\tI-Chemical\nand\tO\nGM\tB-Chemical\nsignificantly\tO\nincreased\tO\ncreatinine\tO\nand\tO\nurea\tB-Chemical\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tB-Chemical\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tB-Chemical\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tB-Chemical\ngroup\tO\n)\tO\nThe\tO\nGM\tB-Chemical\n-\tO\ninduced\tO\nproximal\tO\ntubular\tB-Disease\nnecrosis\tI-Disease\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tB-Chemical\ntogether\tO\nwith\tO\ngum\tB-Chemical\nArabic\tI-Chemical\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tB-Chemical\nand\tO\ncellulose\tO\n.\tO\n\nIt\tO\ncould\tO\nbe\tO\ninferred\tO\nthat\tO\ngum\tO\nArabic\tO\ntreatment\tO\nhas\tO\ninduced\tO\na\tO\nmodest\tO\namelioration\tO\nof\tO\nsome\tO\nof\tO\nthe\tO\nhistological\tO\nand\tO\nbiochemical\tO\nindices\tO\nof\tO\nGM\tB-Chemical\nnephrotoxicity\tB-Disease\n.\tO\n\nFurther\tO\nwork\tO\nis\tO\nwarranted\tO\non\tO\nthe\tO\neffect\tO\nof\tO\nthe\tO\ntreatments\tO\non\tO\nrenal\tO\nfunctional\tO\naspects\tO\nin\tO\nmodels\tO\nof\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nand\tO\non\tO\nthe\tO\nmechanism\tO\n(\tO\ns\tO\n)\tO\ninvolved\tO\n.\tO\n\nIncreased\tO\nfrequency\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\nwith\tO\nthe\tO\ncombination\tO\nof\tO\ndocetaxel\tB-Chemical\nand\tO\nthalidomide\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nmetastatic\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nfrequency\tO\nof\tO\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tB-Disease\n)\tO\nin\tO\npatients\tO\nwith\tO\nadvanced\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tB-Disease\ncancer\tI-Disease\nwho\tO\nwere\tO\ntreated\tO\nwith\tO\ndocetaxel\tB-Chemical\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nthalidomide\tB-Chemical\n.\tO\n\nPATIENTS\tO\n:\tO\nSeventy\tO\nmen\tO\n,\tO\naged\tO\n50\tO\n-\tO\n80\tO\nyears\tO\n,\tO\nwith\tO\nadvanced\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nINTERVENTION\tO\n:\tO\nEach\tO\npatient\tO\nreceived\tO\neither\tO\nintravenous\tO\ndocetaxel\tB-Chemical\n30\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nweek\tO\nfor\tO\n3\tO\nconsecutive\tO\nweeks\tO\n,\tO\nfollowed\tO\nby\tO\n1\tO\nweek\tO\noff\tO\n,\tO\nor\tO\nthe\tO\ncombination\tO\nof\tO\ncontinuous\tO\noral\tO\nthalidomide\tB-Chemical\n200\tO\nmg\tO\nevery\tO\nevening\tO\nplus\tO\nthe\tO\nsame\tO\ndocetaxel\tB-Chemical\nregimen\tO\n.\tO\n\nThis\tO\n4\tO\n-\tO\nweek\tO\ncycle\tO\nwas\tO\nrepeated\tO\nuntil\tO\nthere\tO\nwas\tO\nevidence\tO\nof\tO\nexcessive\tO\ntoxicity\tB-Disease\nor\tO\ndisease\tO\nprogression\tO\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nNone\tO\nof\tO\n23\tO\npatients\tO\nwho\tO\nreceived\tO\ndocetaxel\tB-Chemical\nalone\tO\ndeveloped\tO\nVTE\tB-Disease\n,\tO\nwhereas\tO\n9\tO\nof\tO\n47\tO\npatients\tO\n(\tO\n19\tO\n%\tO\n)\tO\nwho\tO\nreceived\tO\ndocetaxel\tB-Chemical\nplus\tO\nthalidomide\tB-Chemical\ndeveloped\tO\nVTE\tB-Disease\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\naddition\tO\nof\tO\nthalidomide\tB-Chemical\nto\tO\ndocetaxel\tB-Chemical\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nprostate\tB-Disease\ncancer\tI-Disease\nsignificantly\tO\nincreases\tO\nthe\tO\nfrequency\tO\nof\tO\nVTE\tB-Disease\n.\tO\n\nClinicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\npotential\tO\ncomplication\tO\nwhen\tO\nadding\tO\nthalidomide\tB-Chemical\nto\tO\nchemotherapeutic\tO\nregimens\tO\n.\tO\n\nTiclopidine\tB-Chemical\n-\tO\ninduced\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\n2\tO\ncases\tO\nof\tO\nticlopidine\tB-Chemical\n-\tO\ninduced\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n,\tO\ninvestigate\tO\nits\tO\nmechanism\tO\n,\tO\nand\tO\ncompare\tO\nthe\tO\nobserved\tO\nmain\tO\ncharacteristics\tO\nwith\tO\nthose\tO\nof\tO\nthe\tO\npublished\tO\ncases\tO\n.\tO\n\nCASE\tO\nSUMMARIES\tO\n:\tO\nTwo\tO\npatients\tO\ndeveloped\tO\nprolonged\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\nafter\tO\nreceiving\tO\nticlopidine\tB-Chemical\nfollowing\tO\npercutaneous\tO\ncoronary\tO\nangioplasty\tO\n,\tO\nwith\tO\ncomplete\tO\nremission\tO\nduring\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n.\tO\n\nT\tO\n-\tO\ncell\tO\nstimulation\tO\nby\tO\ntherapeutic\tO\nconcentration\tO\nof\tO\nticlopidine\tB-Chemical\nwas\tO\ndemonstrated\tO\nin\tO\nvitro\tO\nin\tO\nthe\tO\npatients\tO\n,\tO\nbut\tO\nnot\tO\nin\tO\nhealthy\tO\ncontrols\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nCholestatic\tB-Disease\nhepatitis\tI-Disease\nis\tO\na\tO\nrare\tO\ncomplication\tO\nof\tO\nthe\tO\nantiplatelet\tO\nagent\tO\nticlopidine\tB-Chemical\n;\tO\nseveral\tO\ncases\tO\nhave\tO\nbeen\tO\nreported\tO\nbut\tO\nfew\tO\nin\tO\nthe\tO\nEnglish\tO\nliterature\tO\n.\tO\n\nOur\tO\npatients\tO\ndeveloped\tO\njaundice\tB-Disease\nfollowing\tO\ntreatment\tO\nwith\tO\nticlopidine\tB-Chemical\nand\tO\nshowed\tO\nthe\tO\nclinical\tO\nand\tO\nlaboratory\tO\ncharacteristics\tO\nof\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n,\tO\nwhich\tO\nresolved\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nAn\tO\nobjective\tO\ncausality\tO\nassessment\tO\nrevealed\tO\nthat\tO\nthe\tO\nadverse\tO\ndrug\tO\nevent\tO\nwas\tO\nprobably\tO\nrelated\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\nticlopidine\tB-Chemical\n.\tO\n\nThe\tO\nmechanisms\tO\nof\tO\nthis\tO\nticlopidine\tB-Chemical\n-\tO\ninduced\tO\ncholestasis\tB-Disease\nare\tO\nunclear\tO\n.\tO\n\nImmune\tO\nmechanisms\tO\nmay\tO\nbe\tO\ninvolved\tO\nin\tO\nthe\tO\ndrug\tO\n'\tO\ns\tO\nhepatotoxicity\tB-Disease\n,\tO\nas\tO\nsuggested\tO\nby\tO\nthe\tO\nT\tO\n-\tO\ncell\tO\nstimulation\tO\nstudy\tO\nreported\tO\nhere\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCholestatic\tB-Disease\nhepatitis\tI-Disease\nis\tO\na\tO\nrare\tO\nadverse\tO\neffect\tO\nof\tO\nticlopidine\tB-Chemical\nthat\tO\nmay\tO\nbe\tO\nimmune\tO\nmediated\tO\n.\tO\n\nThis\tO\ncomplication\tO\nwill\tO\nbe\tO\nobserved\tO\neven\tO\nless\tO\noften\tO\nin\tO\nthe\tO\nfuture\tO\nas\tO\nticlopidine\tB-Chemical\nis\tO\nbeing\tO\nreplaced\tO\nby\tO\nthe\tO\nnewer\tO\nantiplatelet\tO\nagent\tO\nclopidogrel\tB-Chemical\n.\tO\n\nEpithelial\tO\nsodium\tB-Chemical\nchannel\tO\n(\tO\nENaC\tO\n)\tO\nsubunit\tO\nmRNA\tO\nand\tO\nprotein\tO\nexpression\tO\nin\tO\nrats\tO\nwith\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nIn\tO\nexperimental\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n,\tO\nurinary\tO\nsodium\tO\nexcretion\tO\nis\tO\ndecreased\tO\nduring\tO\nthe\tO\nearly\tO\nphase\tO\nof\tO\nthe\tO\ndisease\tO\n.\tO\n\nThe\tO\nrate\tO\n-\tO\nlimiting\tO\nconstituent\tO\nof\tO\ncollecting\tO\nduct\tO\nsodium\tB-Chemical\ntransport\tO\nis\tO\nthe\tO\nepithelial\tO\nsodium\tB-Chemical\nchannel\tO\n(\tO\nENaC\tO\n)\tO\n.\tO\n\nWe\tO\nexamined\tO\nthe\tO\nabundance\tO\nof\tO\nENaC\tO\nsubunit\tO\nmRNAs\tO\nand\tO\nproteins\tO\nin\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tB-Chemical\n)\tO\n-\tO\ninduced\tO\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\ntime\tO\ncourses\tO\nof\tO\nurinary\tO\nsodium\tB-Chemical\nexcretion\tO\n,\tO\nplasma\tO\naldosterone\tB-Chemical\nconcentration\tO\nand\tO\nproteinuria\tB-Disease\nwere\tO\nstudied\tO\nin\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tO\nwith\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\neither\tO\nPAN\tB-Chemical\nor\tO\nvehicle\tO\n.\tO\n\nThe\tO\nkinetics\tO\nof\tO\nurinary\tO\nsodium\tB-Chemical\nexcretion\tO\nand\tO\nthe\tO\nappearance\tO\nof\tO\nproteinuria\tB-Disease\nwere\tO\ncomparable\tO\nwith\tO\nthose\tO\nreported\tO\npreviously\tO\n.\tO\n\nSodium\tB-Chemical\nretention\tO\noccurred\tO\non\tO\ndays\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nafter\tO\nPAN\tB-Chemical\ninjection\tO\n.\tO\n\nA\tO\nsignificant\tO\nup\tO\n-\tO\nregulation\tO\nof\tO\nalphaENaC\tO\nand\tO\nbetaENaC\tO\nmRNA\tO\nabundance\tO\non\tO\ndays\tO\n1\tO\nand\tO\n2\tO\npreceded\tO\nsodium\tB-Chemical\nretention\tO\non\tO\ndays\tO\n2\tO\nand\tO\n3\tO\n.\tO\n\nConversely\tO\n,\tO\ndown\tO\n-\tO\nregulation\tO\nof\tO\nalphaENaC\tO\n,\tO\nbetaENaC\tO\nand\tO\ngammaENaC\tO\nmRNA\tO\nexpression\tO\non\tO\nday\tO\n3\tO\noccurred\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nhigh\tO\naldosterone\tB-Chemical\nconcentrations\tO\n,\tO\nand\tO\nwas\tO\nfollowed\tO\nby\tO\na\tO\nreturn\tO\nof\tO\nsodium\tB-Chemical\nexcretion\tO\nto\tO\ncontrol\tO\nvalues\tO\n.\tO\n\nThe\tO\namounts\tO\nof\tO\nalphaENaC\tO\n,\tO\nbetaENaC\tO\nand\tO\ngammaENaC\tO\nproteins\tO\nwere\tO\nnot\tO\nincreased\tO\nduring\tO\nPAN\tB-Chemical\n-\tO\ninduced\tO\nsodium\tB-Chemical\nretention\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nENaC\tO\nmRNA\tO\nexpression\tO\n,\tO\nespecially\tO\nalphaENaC\tO\n,\tO\nis\tO\nincreased\tO\nin\tO\nthe\tO\nvery\tO\nearly\tO\nphase\tO\nof\tO\nthe\tO\nexperimental\tO\nmodel\tO\nof\tO\nPAN\tB-Chemical\n-\tO\ninduced\tO\nnephrotic\tO\nsyndrome\tO\nin\tO\nrats\tO\n,\tO\nbut\tO\nappears\tO\nto\tO\nescape\tO\nfrom\tO\nthe\tO\nregulation\tO\nby\tO\naldosterone\tB-Chemical\nafter\tO\nday\tO\n3\tO\n.\tO\n\nSub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\ngamma\tB-Chemical\n-\tI-Chemical\nvinyl\tI-Chemical\nGABA\tI-Chemical\n(\tO\nvigabatrin\tB-Chemical\n)\tO\ninhibits\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\ndopamine\tB-Chemical\n.\tO\n\nRATIONALE\tO\n:\tO\ngamma\tB-Chemical\n-\tI-Chemical\nVinyl\tI-Chemical\nGABA\tI-Chemical\n(\tO\nGVG\tB-Chemical\n)\tO\nirreversibly\tO\ninhibits\tO\nGABA\tB-Chemical\n-\tO\ntransaminase\tO\n.\tO\n\nThis\tO\nnon\tO\n-\tO\nreceptor\tO\nmediated\tO\ninhibition\tO\nrequires\tO\nde\tO\nnovo\tO\nsynthesis\tO\nfor\tO\nrestoration\tO\nof\tO\nfunctional\tO\nGABA\tB-Chemical\ncatabolism\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nGiven\tO\nits\tO\npreclinical\tO\nsuccess\tO\nfor\tO\ntreating\tO\nsubstance\tB-Disease\nabuse\tI-Disease\nand\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\nvisual\tB-Disease\nfield\tI-Disease\ndefects\tI-Disease\n(\tO\nVFD\tB-Disease\n)\tO\nassociated\tO\nwith\tO\ncumulative\tO\nlifetime\tO\nexposure\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\neffects\tO\nof\tO\nsub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tB-Chemical\non\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\n(\tO\nNAcc\tO\n)\tO\ndopamine\tB-Chemical\n(\tO\nDA\tB-Chemical\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSub\tO\n-\tO\nchronic\tO\nGVG\tB-Chemical\nexposure\tO\ninhibited\tO\nthe\tO\neffect\tO\nof\tO\ncocaine\tB-Chemical\nfor\tO\n3\tO\ndays\tO\n,\tO\nwhich\tO\nexceeded\tO\nin\tO\nmagnitude\tO\nand\tO\nduration\tO\nthe\tO\nidentical\tO\nacute\tO\ndose\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tB-Chemical\npotentiates\tO\nand\tO\nextends\tO\nthe\tO\ninhibition\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tO\nincreases\tO\nin\tO\ndopamine\tB-Chemical\n,\tO\neffectively\tO\nreducing\tO\ncumulative\tO\nexposures\tO\nand\tO\nthe\tO\nrisk\tO\nfor\tO\nVFDS\tO\n.\tO\n\nMR\tO\nimaging\tO\nwith\tO\nquantitative\tO\ndiffusion\tO\nmapping\tO\nof\tO\ntacrolimus\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\nin\tO\norgan\tO\ntransplant\tO\npatients\tO\n.\tO\n\nOur\tO\nobjective\tO\nwas\tO\nto\tO\ninvestigate\tO\nbrain\tO\nMR\tO\nimaging\tO\nfindings\tO\nand\tO\nthe\tO\nutility\tO\nof\tO\ndiffusion\tO\n-\tO\nweighted\tO\n(\tO\nDW\tO\n)\tO\nimaging\tO\nin\tO\norgan\tO\ntransplant\tO\npatients\tO\nwho\tO\ndeveloped\tO\nneurologic\tO\nsymptoms\tO\nduring\tO\ntacrolimus\tB-Chemical\ntherapy\tO\n.\tO\n\nBrain\tO\nMR\tO\nstudies\tO\n,\tO\nincluding\tO\nDW\tO\nimaging\tO\n,\tO\nwere\tO\nprospectively\tO\nperformed\tO\nin\tO\n14\tO\norgan\tO\ntransplant\tO\npatients\tO\nreceiving\tO\ntacrolimus\tB-Chemical\nwho\tO\ndeveloped\tO\nneurologic\tB-Disease\ncomplications\tI-Disease\n.\tO\n\nOf\tO\nthe\tO\n14\tO\npatients\tO\n,\tO\n5\tO\n(\tO\n35\tO\n.\tO\n7\tO\n%\tO\n)\tO\nhad\tO\nwhite\tB-Disease\nmatter\tI-Disease\nabnormalities\tI-Disease\n,\tO\n1\tO\n(\tO\n7\tO\n.\tO\n1\tO\n%\tO\n)\tO\nhad\tO\nputaminal\tB-Disease\nhemorrhage\tI-Disease\n,\tO\nand\tO\n8\tO\n(\tO\n57\tO\n.\tO\n1\tO\n%\tO\n)\tO\nhad\tO\nnormal\tO\nfindings\tO\non\tO\ninitial\tO\nMR\tO\nimages\tO\n.\tO\n\nAmong\tO\nthe\tO\n5\tO\npatients\tO\nwith\tO\nwhite\tB-Disease\nmatter\tI-Disease\nabnormalities\tI-Disease\n,\tO\n4\tO\npatients\tO\n(\tO\n80\tO\n.\tO\n0\tO\n%\tO\n)\tO\nshowed\tO\nhigher\tO\nthan\tO\nnormal\tO\nADC\tO\nvalues\tO\non\tO\ninitial\tO\nMR\tO\nimages\tO\n,\tO\nand\tO\nall\tO\nshowed\tO\ncomplete\tO\nresolution\tO\non\tO\nfollow\tO\n-\tO\nup\tO\nimages\tO\n.\tO\n\nThe\tO\nremaining\tO\n1\tO\npatient\tO\n(\tO\n20\tO\n.\tO\n0\tO\n%\tO\n)\tO\nshowed\tO\nlower\tO\nthan\tO\nnormal\tO\nADC\tO\nvalue\tO\nand\tO\nshowed\tO\nincomplete\tO\nresolution\tO\nwith\tO\ncortical\tB-Disease\nlaminar\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nDiffusion\tO\n-\tO\nweighted\tO\nimaging\tO\nmay\tO\nbe\tO\nuseful\tO\nin\tO\npredicting\tO\nthe\tO\noutcomes\tO\nof\tO\nthe\tO\nlesions\tO\nof\tO\ntacrolimus\tB-Chemical\n-\tO\ninduced\tO\nneurotoxicity\tB-Disease\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntransport\tO\nin\tO\nhumans\tO\nwith\tO\ncortisol\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n.\tO\n\nA\tO\ndeficient\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n-\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsystem\tO\nis\tO\nimplicated\tO\nin\tO\ncortisol\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tB-Disease\n.\tO\n\nWe\tO\ninvestigate\tO\nwhether\tO\nabnormalities\tO\nin\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nuptake\tO\ncontribute\tO\nto\tO\nthis\tO\ndeficiency\tO\n.\tO\n\nHydrocortisone\tB-Chemical\nacetate\tI-Chemical\n(\tO\n50\tO\nmg\tO\n)\tO\nwas\tO\ngiven\tO\norally\tO\nevery\tO\n6\tO\nhours\tO\nfor\tO\n24\tO\nhours\tO\nafter\tO\na\tO\n5\tO\n-\tO\nday\tO\nfixed\tO\n-\tO\nsalt\tO\ndiet\tO\n(\tO\n150\tO\nmmol\tO\n/\tO\nd\tO\n)\tO\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nuptake\tO\nwas\tO\nassessed\tO\nin\tO\nmononuclear\tO\ncells\tO\nincubated\tO\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n(\tO\n1\tO\nto\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\n,\tO\nincorporating\tO\n100\tO\nnmol\tO\n/\tO\nL\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nfor\tO\na\tO\nperiod\tO\nof\tO\n5\tO\nminutes\tO\nat\tO\n37\tO\ndegrees\tO\nC\tO\n.\tO\n\nForearm\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nextraction\tO\nwas\tO\ncalculated\tO\nafter\tO\ninfusion\tO\nof\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ninto\tO\nthe\tO\nbrachial\tO\nartery\tO\nat\tO\na\tO\nrate\tO\nof\tO\n100\tO\nnCi\tO\n/\tO\nmin\tO\nfor\tO\n80\tO\nminutes\tO\n.\tO\n\nDeep\tO\nforearm\tO\nvenous\tO\nsamples\tO\nwere\tO\ncollected\tO\nfor\tO\ndetermination\tO\nof\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nextraction\tO\n.\tO\n\nPlasma\tO\ncortisol\tB-Chemical\nconcentrations\tO\nwere\tO\nsignificantly\tO\nraised\tO\nduring\tO\nthe\tO\nactive\tO\nphase\tO\n(\tO\n323\tO\n+\tO\n/\tO\n-\tO\n43\tO\nto\tO\n1082\tO\n+\tO\n/\tO\n-\tO\n245\tO\nmmol\tO\n/\tO\nL\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nNeither\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntransport\tO\ninto\tO\nmononuclear\tO\ncells\tO\n(\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n26\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n6\tO\nvs\tO\n29\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\npmol\tO\n/\tO\n10\tO\n000\tO\ncells\tO\nper\tO\n5\tO\nminutes\tO\n,\tO\nrespectively\tO\n,\tO\nat\tO\nan\tO\nl\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nconcentration\tO\nof\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nnor\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nextraction\tO\nin\tO\nthe\tO\nforearm\tO\n(\tO\nat\tO\n80\tO\nminutes\tO\n,\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n1\tO\n868\tO\n904\tO\n+\tO\n/\tO\n-\tO\n434\tO\n962\tO\nvs\tO\n2\tO\n013\tO\n910\tO\n+\tO\n/\tO\n-\tO\n770\tO\n619\tO\ndisintegrations\tO\nper\tO\nminute\tO\n)\tO\nwas\tO\naffected\tO\nby\tO\ncortisol\tB-Chemical\ntreatment\tO\n;\tO\nie\tO\n,\tO\nthat\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nuptake\tO\nis\tO\nnot\tO\naffected\tO\nby\tO\nshort\tO\n-\tO\nterm\tO\ncortisol\tB-Chemical\ntreatment\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\ncortisol\tB-Chemical\n-\tO\ninduced\tO\nincreases\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nare\tO\nnot\tO\nassociated\tO\nwith\tO\nabnormalities\tO\nin\tO\nthe\tO\nl\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntransport\tO\nsystem\tO\n.\tO\n\nAmount\tO\nof\tO\nbleeding\tB-Disease\nand\tO\nhematoma\tB-Disease\nsize\tO\nin\tO\nthe\tO\ncollagenase\tO\n-\tO\ninduced\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\nrat\tO\nmodel\tO\n.\tO\n\nThe\tO\naggravated\tO\nrisk\tO\non\tO\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n(\tO\nICH\tB-Disease\n)\tO\nwith\tO\ndrugs\tO\nused\tO\nfor\tO\nstroke\tB-Disease\npatients\tO\nshould\tO\nbe\tO\nestimated\tO\ncarefully\tO\n.\tO\n\nWe\tO\ntherefore\tO\nestablished\tO\nsensitive\tO\nquantification\tO\nmethods\tO\nand\tO\nprovided\tO\na\tO\nrat\tO\nICH\tB-Disease\nmodel\tO\nfor\tO\ndetection\tO\nof\tO\nICH\tB-Disease\ndeterioration\tO\n.\tO\n\nIn\tO\nICH\tB-Disease\nintrastriatally\tO\ninduced\tO\nby\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\n,\tO\n0\tO\n.\tO\n070\tO\n-\tO\nunit\tO\n,\tO\nand\tO\n0\tO\n.\tO\n350\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nthe\tO\namount\tO\nof\tO\nbleeding\tB-Disease\nwas\tO\nmeasured\tO\nusing\tO\na\tO\nhemoglobin\tO\nassay\tO\ndeveloped\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\nand\tO\nwas\tO\ncompared\tO\nwith\tO\nthe\tO\nmorphologically\tO\ndetermined\tO\nhematoma\tB-Disease\nvolume\tO\n.\tO\n\nThe\tO\nblood\tO\namounts\tO\nand\tO\nhematoma\tB-Disease\nvolumes\tO\nwere\tO\nsignificantly\tO\ncorrelated\tO\n,\tO\nand\tO\nthe\tO\nhematoma\tB-Disease\ninduced\tO\nby\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\nwas\tO\nadequate\tO\nto\tO\ndetect\tO\nICH\tB-Disease\ndeterioration\tO\n.\tO\n\nIn\tO\nICH\tB-Disease\ninduction\tO\nusing\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nheparin\tB-Chemical\nenhanced\tO\nthe\tO\nhematoma\tB-Disease\nvolume\tO\n3\tO\n.\tO\n4\tO\n-\tO\nfold\tO\nover\tO\nthat\tO\nseen\tO\nin\tO\ncontrol\tO\nICH\tB-Disease\nanimals\tO\nand\tO\nthe\tO\nbleeding\tB-Disease\n7\tO\n.\tO\n6\tO\n-\tO\nfold\tO\n.\tO\n\nData\tO\nsuggest\tO\nthat\tO\nthis\tO\nsensitive\tO\nhemoglobin\tO\nassay\tO\nis\tO\nuseful\tO\nfor\tO\nICH\tB-Disease\ndetection\tO\n,\tO\nand\tO\nthat\tO\na\tO\nmodel\tO\nwith\tO\na\tO\nsmall\tO\nICH\tB-Disease\ninduced\tO\nwith\tO\na\tO\nlow\tO\n-\tO\ndose\tO\ncollagenase\tO\nshould\tO\nbe\tO\nused\tO\nfor\tO\nevaluation\tO\nof\tO\ndrugs\tO\nthat\tO\nmay\tO\naffect\tO\nICH\tB-Disease\n.\tO\n\nEstradiol\tB-Chemical\nreduces\tO\nseizure\tB-Disease\n-\tO\ninduced\tO\nhippocampal\tB-Disease\ninjury\tI-Disease\nin\tO\novariectomized\tO\nfemale\tO\nbut\tO\nnot\tO\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nEstrogens\tO\nprotect\tO\novariectomized\tO\nrats\tO\nfrom\tO\nhippocampal\tB-Disease\ninjury\tI-Disease\ninduced\tO\nby\tO\nkainic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nstatus\tB-Disease\nepilepticus\tI-Disease\n(\tO\nSE\tB-Disease\n)\tO\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\neffects\tO\nof\tO\n17beta\tB-Chemical\n-\tI-Chemical\nestradiol\tI-Chemical\nin\tO\nadult\tO\nmale\tO\nand\tO\novariectomized\tO\nfemale\tO\nrats\tO\nsubjected\tO\nto\tO\nlithium\tB-Chemical\n-\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tO\nSE\tB-Disease\n.\tO\n\nRats\tO\nreceived\tO\nsubcutaneous\tO\ninjections\tO\nof\tO\n17beta\tB-Chemical\n-\tI-Chemical\nestradiol\tI-Chemical\n(\tO\n2\tO\nmicrog\tO\n/\tO\nrat\tO\n)\tO\nor\tO\noil\tO\nonce\tO\ndaily\tO\nfor\tO\nfour\tO\nconsecutive\tO\ndays\tO\n.\tO\n\nSE\tB-Disease\nwas\tO\ninduced\tO\n20\tO\nh\tO\nfollowing\tO\nthe\tO\nsecond\tO\ninjection\tO\nand\tO\nterminated\tO\n3\tO\nh\tO\nlater\tO\n.\tO\n\nThe\tO\nextent\tO\nof\tO\nsilver\tB-Chemical\n-\tO\nstained\tO\nCA3\tO\nand\tO\nCA1\tO\nhippocampal\tO\nneurons\tO\nwas\tO\nevaluated\tO\n2\tO\ndays\tO\nafter\tO\nSE\tB-Disease\n.\tO\n\n17beta\tB-Chemical\n-\tI-Chemical\nEstradiol\tI-Chemical\ndid\tO\nnot\tO\nalter\tO\nthe\tO\nonset\tO\nof\tO\nfirst\tO\nclonus\tO\nin\tO\novariectomized\tO\nrats\tO\nbut\tO\naccelerated\tO\nit\tO\nin\tO\nmales\tO\n.\tO\n\n17beta\tB-Chemical\n-\tI-Chemical\nEstradiol\tI-Chemical\nreduced\tO\nthe\tO\nargyrophilic\tO\nneurons\tO\nin\tO\nthe\tO\nCA1\tO\nand\tO\nCA3\tO\n-\tO\nC\tO\nsectors\tO\nof\tO\novariectomized\tO\nrats\tO\n.\tO\n\nIn\tO\nmales\tO\n,\tO\nestradiol\tB-Chemical\nincreased\tO\nthe\tO\ntotal\tO\ndamage\tO\nscore\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nthe\tO\neffects\tO\nof\tO\nestradiol\tB-Chemical\non\tO\nseizure\tB-Disease\nthreshold\tO\nand\tO\ndamage\tO\nmay\tO\nbe\tO\naltered\tO\nby\tO\nsex\tO\n-\tO\nrelated\tO\ndifferences\tO\nin\tO\nthe\tO\nhormonal\tO\nenvironment\tO\n.\tO\n\nPseudoacromegaly\tB-Disease\ninduced\tO\nby\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nminoxidil\tB-Chemical\n.\tO\n\nAcromegaly\tB-Disease\nis\tO\nan\tO\nendocrine\tB-Disease\ndisorder\tI-Disease\ncaused\tO\nby\tO\nchronic\tO\nexcessive\tO\ngrowth\tO\nhormone\tO\nsecretion\tO\nfrom\tO\nthe\tO\nanterior\tO\npituitary\tO\ngland\tO\n.\tO\n\nSignificant\tO\ndisfiguring\tO\nchanges\tO\noccur\tO\nas\tO\na\tO\nresult\tO\nof\tO\nbone\tO\n,\tO\ncartilage\tO\n,\tO\nand\tO\nsoft\tO\ntissue\tO\nhypertrophy\tO\n,\tO\nincluding\tO\nthe\tO\nthickening\tO\nof\tO\nthe\tO\nskin\tO\n,\tO\ncoarsening\tO\nof\tO\nfacial\tO\nfeatures\tO\n,\tO\nand\tO\ncutis\tB-Disease\nverticis\tI-Disease\ngyrata\tI-Disease\n.\tO\n\nPseudoacromegaly\tB-Disease\n,\tO\non\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nis\tO\nthe\tO\npresence\tO\nof\tO\nsimilar\tO\nacromegaloid\tO\nfeatures\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nelevated\tO\ngrowth\tO\nhormone\tO\nor\tO\ninsulin\tO\n-\tO\nlike\tO\ngrowth\tO\nfactor\tO\nlevels\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\npatient\tO\nwith\tO\npseudoacromegaly\tB-Disease\nthat\tO\nresulted\tO\nfrom\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nminoxidil\tB-Chemical\nat\tO\nan\tO\nunusually\tO\nhigh\tO\ndose\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\npseudoacromegaly\tB-Disease\nas\tO\na\tO\nside\tO\neffect\tO\nof\tO\nminoxidil\tB-Chemical\nuse\tO\n.\tO\n\nCombined\tO\nandrogen\tO\nblockade\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nin\tO\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tO\nwithout\tO\nbone\tO\ninvolvement\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nonset\tO\nand\tO\nextent\tO\nof\tO\ncombined\tO\nandrogen\tO\nblockade\tO\n(\tO\nCAB\tO\n)\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nin\tO\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tO\nwithout\tO\nbone\tO\ninvolvement\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nForty\tO\n-\tO\ntwo\tO\npatients\tO\nwith\tO\nbiopsy\tO\n-\tO\nproven\tO\nprostatic\tB-Disease\nadenocarcinoma\tI-Disease\n[\tO\n26\tO\nwith\tO\nstage\tO\nC\tO\n(\tO\nT3N0M0\tO\n)\tO\nand\tO\n16\tO\nwith\tO\nstage\tO\nD1\tO\n(\tO\nT3N1M0\tO\n)\tO\n]\tO\nwere\tO\nincluded\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nAll\tO\npatients\tO\nreceived\tO\nCAB\tO\n[\tO\nleuprolide\tB-Chemical\nacetate\tI-Chemical\n(\tO\nLHRH\tB-Chemical\n-\tI-Chemical\nA\tI-Chemical\n)\tO\n3\tO\n.\tO\n75\tO\nmg\tO\n,\tO\nintramuscularly\tO\n,\tO\nevery\tO\n28\tO\ndays\tO\nplus\tO\n250\tO\nmg\tO\nflutamide\tB-Chemical\n,\tO\ntid\tO\n,\tO\nper\tO\nOs\tO\n]\tO\nand\tO\nwere\tO\nevaluated\tO\nfor\tO\nanemia\tB-Disease\nby\tO\nphysical\tO\nexamination\tO\nand\tO\nlaboratory\tO\ntests\tO\nat\tO\nbaseline\tO\nand\tO\n4\tO\nsubsequent\tO\nintervals\tO\n(\tO\n1\tO\n,\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n)\tO\n.\tO\n\nHb\tO\n,\tO\nPSA\tO\nand\tO\nTestosterone\tB-Chemical\nmeasurements\tO\nwere\tO\nrecorded\tO\n.\tO\n\nSevere\tO\nand\tO\nclinically\tO\nevident\tO\nanemia\tB-Disease\nof\tO\nHb\tO\n<\tO\n11\tO\ng\tO\n/\tO\ndl\tO\nwith\tO\nclinical\tO\nsymptoms\tO\nwas\tO\ndetected\tO\nin\tO\n6\tO\npatients\tO\n(\tO\n14\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThis\tO\nCAB\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nwas\tO\nnormochromic\tO\nand\tO\nnormocytic\tO\n.\tO\n\nAt\tO\nsix\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n,\tO\npatients\tO\nwith\tO\nsevere\tO\nanemia\tB-Disease\nhad\tO\na\tO\nHb\tO\nmean\tO\nvalue\tO\nof\tO\n10\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\ng\tO\n/\tO\ndl\tO\n(\tO\nX\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n,\tO\nwhereas\tO\nthe\tO\nother\tO\npatients\tO\nhad\tO\nmild\tO\nanemia\tB-Disease\nwith\tO\nHb\tO\nmean\tO\nvalue\tO\nof\tO\n13\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n17\tO\n(\tO\nX\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nsevere\tO\nanemia\tB-Disease\nat\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\nwas\tO\npredictable\tO\nby\tO\nthe\tO\nreduction\tO\nof\tO\nHb\tO\nbaseline\tO\nvalue\tO\nof\tO\nmore\tO\nthan\tO\n2\tO\n.\tO\n5\tO\ng\tO\n/\tO\ndl\tO\nafter\tO\n3\tO\nmonths\tO\nof\tO\nCAB\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nsevere\tO\nCAB\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nin\tO\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tO\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nT\tO\nbaseline\tO\nvalues\tO\n(\tO\nT\tO\n<\tO\n3\tO\nng\tO\n/\tO\nml\tO\nversus\tO\nT\tO\n>\tO\nor\tO\n=\tO\n3\tO\nng\tO\n/\tO\nml\tO\n)\tO\n,\tO\nwith\tO\nage\tO\n(\tO\n<\tO\n76\tO\nyrs\tO\nversus\tO\n>\tO\nor\tO\n=\tO\n76\tO\nyrs\tO\n)\tO\n,\tO\nand\tO\nclinical\tO\nstage\tO\n(\tO\nstage\tO\nC\tO\nversus\tO\nstage\tO\nD1\tO\n)\tO\n.\tO\n\nSevere\tO\nand\tO\nclinically\tO\nevident\tO\nanemia\tB-Disease\nwas\tO\neasily\tO\ncorrected\tO\nby\tO\nsubcutaneous\tO\ninjections\tO\n(\tO\n3\tO\ntimes\tO\n/\tO\nweek\tO\nfor\tO\n1\tO\nmonth\tO\n)\tO\nof\tO\nrecombinant\tO\nerythropoietin\tO\n(\tO\nrHuEPO\tO\n-\tO\nbeta\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\ndata\tO\nsuggest\tO\nthat\tO\nrHuEPO\tO\n-\tO\nbeta\tO\ncorrectable\tO\nCAB\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\noccurs\tO\nin\tO\n14\tO\n.\tO\n3\tO\n%\tO\nof\tO\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tO\nafter\tO\n6\tO\nmonths\tO\nof\tO\ntherapy\tO\n.\tO\n\nDelirium\tB-Disease\nduring\tO\nclozapine\tB-Chemical\ntreatment\tO\n:\tO\nincidence\tO\nand\tO\nassociated\tO\nrisk\tO\nfactors\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIncidence\tO\nand\tO\nrisk\tO\nfactors\tO\nfor\tO\ndelirium\tB-Disease\nduring\tO\nclozapine\tB-Chemical\ntreatment\tO\nrequire\tO\nfurther\tO\nclarification\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nused\tO\ncomputerized\tO\npharmacy\tO\nrecords\tO\nto\tO\nidentify\tO\nall\tO\nadult\tO\npsychiatric\tB-Disease\ninpatients\tO\ntreated\tO\nwith\tO\nclozapine\tB-Chemical\n(\tO\n1995\tO\n-\tO\n96\tO\n)\tO\n,\tO\nreviewed\tO\ntheir\tO\nmedical\tO\nrecords\tO\nto\tO\nscore\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\ndelirium\tB-Disease\n,\tO\nand\tO\ntested\tO\nassociations\tO\nwith\tO\npotential\tO\nrisk\tO\nfactors\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSubjects\tO\n(\tO\nn\tO\n=\tO\n139\tO\n)\tO\nwere\tO\n72\tO\nwomen\tO\nand\tO\n67\tO\nmen\tO\n,\tO\naged\tO\n40\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n12\tO\n.\tO\n1\tO\nyears\tO\n,\tO\nhospitalized\tO\nfor\tO\n24\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n23\tO\n.\tO\n3\tO\ndays\tO\n,\tO\nand\tO\ngiven\tO\nclozapine\tB-Chemical\n,\tO\ngradually\tO\nincreased\tO\nto\tO\nan\tO\naverage\tO\ndaily\tO\ndose\tO\nof\tO\n282\tO\n+\tO\n/\tO\n-\tO\n203\tO\nmg\tO\n(\tO\n3\tO\n.\tO\n45\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n45\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nfor\tO\n18\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n16\tO\n.\tO\n4\tO\ndays\tO\n.\tO\n\nDelirium\tB-Disease\nwas\tO\ndiagnosed\tO\nin\tO\n14\tO\n(\tO\n10\tO\n.\tO\n1\tO\n%\tO\nincidence\tO\n,\tO\nor\tO\n1\tO\n.\tO\n48\tO\ncases\tO\n/\tO\nperson\tO\n-\tO\nyears\tO\nof\tO\nexposure\tO\n)\tO\n;\tO\n71\tO\n.\tO\n4\tO\n%\tO\nof\tO\ncases\tO\nwere\tO\nmoderate\tO\nor\tO\nsevere\tO\n.\tO\n\nAssociated\tO\nfactors\tO\nwere\tO\nco\tO\n-\tO\ntreatment\tO\nwith\tO\nother\tO\ncentrally\tO\nantimuscarinic\tO\nagents\tO\n,\tO\npoor\tO\nclinical\tO\noutcome\tO\n,\tO\nolder\tO\nage\tO\n,\tO\nand\tO\nlonger\tO\nhospitalization\tO\n(\tO\nby\tO\n17\tO\n.\tO\n5\tO\ndays\tO\n,\tO\nincreasing\tO\ncost\tO\n)\tO\n;\tO\nsex\tO\n,\tO\ndiagnosis\tO\nor\tO\nmedical\tO\nco\tO\n-\tO\nmorbidity\tO\n,\tO\nand\tO\ndaily\tO\nclozapine\tB-Chemical\ndose\tO\n,\tO\nwhich\tO\nfell\tO\nwith\tO\nage\tO\n,\tO\nwere\tO\nunrelated\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDelirium\tB-Disease\nwas\tO\nfound\tO\nin\tO\n10\tO\n%\tO\nof\tO\nclozapine\tB-Chemical\n-\tO\ntreated\tO\ninpatients\tO\n,\tO\nparticularly\tO\nin\tO\nolder\tO\npatients\tO\nexposed\tO\nto\tO\nother\tO\ncentral\tO\nanticholinergics\tO\n.\tO\n\nDelirium\tB-Disease\nwas\tO\ninconsistently\tO\nrecognized\tO\nclinically\tO\nin\tO\nmilder\tO\ncases\tO\nand\tO\nwas\tO\nassociated\tO\nwith\tO\nincreased\tO\nlength\tO\n-\tO\nof\tO\n-\tO\nstay\tO\nand\tO\nhigher\tO\ncosts\tO\n,\tO\nand\tO\ninferior\tO\nclinical\tO\noutcome\tO\n.\tO\n\nNeuroprotective\tO\naction\tO\nof\tO\nMPEP\tB-Chemical\n,\tO\na\tO\nselective\tO\nmGluR5\tO\nantagonist\tO\n,\tO\nin\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\ndopaminergic\tO\nneurotoxicity\tB-Disease\nis\tO\nassociated\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\ndopamine\tB-Chemical\noutflow\tO\nand\tO\ninhibition\tO\nof\tO\nhyperthermia\tB-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\nrole\tO\nof\tO\nmetabotropic\tO\nglutamate\tB-Chemical\nreceptor\tO\n5\tO\n(\tO\nmGluR5\tO\n)\tO\nin\tO\nthe\tO\ntoxic\tO\naction\tO\nof\tO\nmethamphetamine\tB-Chemical\non\tO\ndopaminergic\tO\nneurones\tO\nin\tO\nrats\tO\n.\tO\n\nMethamphetamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\n,\tO\nadministered\tO\nfive\tO\ntimes\tO\n,\tO\nreduced\tO\nthe\tO\nlevels\tO\nof\tO\ndopamine\tB-Chemical\nand\tO\nits\tO\nmetabolites\tO\nin\tO\nstriatal\tO\ntissue\tO\nwhen\tO\nmeasured\tO\n72\tO\nh\tO\nafter\tO\nthe\tO\nlast\tO\ninjection\tO\n.\tO\n\nA\tO\nselective\tO\nantagonist\tO\nof\tO\nmGluR5\tO\n,\tO\n2\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\nphenylethynyl\tI-Chemical\n)\tI-Chemical\npyridine\tI-Chemical\n(\tO\nMPEP\tB-Chemical\n;\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\n,\tO\nwhen\tO\nadministered\tO\nfive\tO\ntimes\tO\nimmediately\tO\nbefore\tO\neach\tO\nmethamphetamine\tB-Chemical\ninjection\tO\nreversed\tO\nthe\tO\nabove\tO\n-\tO\nmentioned\tO\nmethamphetamine\tB-Chemical\neffects\tO\n.\tO\n\nA\tO\nsingle\tO\nMPEP\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\ninjection\tO\nreduced\tO\nthe\tO\nbasal\tO\nextracellular\tO\ndopamine\tB-Chemical\nlevel\tO\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nas\tO\nwell\tO\nas\tO\ndopamine\tB-Chemical\nrelease\tO\nstimulated\tO\neither\tO\nby\tO\nmethamphetamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\nor\tO\nby\tO\nintrastriatally\tO\nadministered\tO\nveratridine\tB-Chemical\n(\tO\n100\tO\nmicroM\tO\n)\tO\n.\tO\n\nMoreover\tO\n,\tO\nit\tO\ntransiently\tO\ndiminished\tO\nthe\tO\nmethamphetamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\n-\tO\ninduced\tO\nhyperthermia\tB-Disease\nand\tO\nreduced\tO\nbasal\tO\nbody\tO\ntemperature\tO\n.\tO\n\nMPEP\tB-Chemical\nadministered\tO\ninto\tO\nthe\tO\nstriatum\tO\nat\tO\nhigh\tO\nconcentrations\tO\n(\tO\n500\tO\nmicroM\tO\n)\tO\nincreased\tO\nextracellular\tO\ndopamine\tB-Chemical\nlevels\tO\n,\tO\nwhile\tO\nlower\tO\nconcentrations\tO\n(\tO\n50\tO\n-\tO\n100\tO\nmicroM\tO\n)\tO\nwere\tO\ndevoid\tO\nof\tO\nany\tO\neffect\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthis\tO\nstudy\tO\nsuggest\tO\nthat\tO\nthe\tO\nblockade\tO\nof\tO\nmGluR5\tO\nby\tO\nMPEP\tB-Chemical\nmay\tO\nprotect\tO\ndopaminergic\tO\nneurones\tO\nagainst\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\ntoxicity\tB-Disease\n.\tO\n\nNeuroprotection\tO\nrendered\tO\nby\tO\nMPEP\tB-Chemical\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nreduction\tO\nof\tO\nthe\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\ndopamine\tB-Chemical\nefflux\tO\nin\tO\nthe\tO\nstriatum\tO\ndue\tO\nto\tO\nthe\tO\nblockade\tO\nof\tO\nextrastriatal\tO\nmGluR5\tO\n,\tO\nand\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\nhyperthermia\tB-Disease\n.\tO\n\nProtective\tO\nefficacy\tO\nof\tO\nneuroactive\tO\nsteroids\tB-Chemical\nagainst\tO\ncocaine\tB-Chemical\nkindled\tO\n-\tO\nseizures\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nNeuroactive\tO\nsteroids\tB-Chemical\ndemonstrate\tO\npharmacological\tO\nactions\tO\nthat\tO\nhave\tO\nrelevance\tO\nfor\tO\na\tO\nhost\tO\nof\tO\nneurological\tB-Disease\nand\tI-Disease\npsychiatric\tI-Disease\ndisorders\tI-Disease\n.\tO\n\nThey\tO\noffer\tO\nprotection\tO\nagainst\tO\nseizures\tB-Disease\nin\tO\na\tO\nrange\tO\nof\tO\nmodels\tO\nand\tO\nseem\tO\nto\tO\ninhibit\tO\ncertain\tO\nstages\tO\nof\tO\ndrug\tB-Disease\ndependence\tI-Disease\nin\tO\npreclinical\tO\nassessments\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\ntwo\tO\nendogenous\tO\nand\tO\none\tO\nsynthetic\tO\nneuroactive\tO\nsteroid\tB-Chemical\nthat\tO\npositively\tO\nmodulate\tO\nthe\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n(\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\n)\tO\nreceptor\tO\nagainst\tO\nthe\tO\nincrease\tO\nin\tO\nsensitivity\tO\nto\tO\nthe\tO\nconvulsant\tO\neffects\tO\nof\tO\ncocaine\tB-Chemical\nengendered\tO\nby\tO\nrepeated\tO\ncocaine\tB-Chemical\nadministration\tO\n(\tO\nseizure\tB-Disease\nkindling\tO\n)\tO\n.\tO\n\nAllopregnanolone\tB-Chemical\n(\tO\n3alpha\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n5alpha\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n)\tO\n,\tO\npregnanolone\tB-Chemical\n(\tO\n3alpha\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n5beta\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n)\tO\nand\tO\nganaxolone\tB-Chemical\n(\tO\na\tO\nsynthetic\tO\nderivative\tO\nof\tO\nallopregnanolone\tB-Chemical\n3alpha\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n3beta\tI-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\n5alpha\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n)\tO\nwere\tO\ntested\tO\nfor\tO\ntheir\tO\nability\tO\nto\tO\nsuppress\tO\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\nkindled\tO\nseizures\tB-Disease\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nKindled\tO\nseizures\tB-Disease\nwere\tO\ninduced\tO\nby\tO\ndaily\tO\nadministration\tO\nof\tO\n60\tO\nmg\tO\n/\tO\nkg\tO\ncocaine\tB-Chemical\nfor\tO\n5\tO\ndays\tO\n.\tO\n\nAll\tO\nof\tO\nthese\tO\npositive\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nmodulators\tO\nsuppressed\tO\nthe\tO\nexpression\tO\nof\tO\nkindled\tO\nseizures\tB-Disease\n,\tO\nwhereas\tO\nonly\tO\nallopregnanolone\tB-Chemical\nand\tO\nganaxolone\tB-Chemical\ninhibited\tO\nthe\tO\ndevelopment\tO\nof\tO\nkindling\tO\n.\tO\n\nAllopregnanolone\tB-Chemical\nand\tO\npregnanolone\tB-Chemical\n,\tO\nbut\tO\nnot\tO\nganaxolone\tB-Chemical\n,\tO\nalso\tO\nreduced\tO\ncumulative\tO\nlethality\tO\nassociated\tO\nwith\tO\nkindling\tO\n.\tO\n\nThese\tO\nfindings\tO\ndemonstrate\tO\nthat\tO\nsome\tO\nneuroactive\tO\nsteroids\tB-Chemical\nattenuate\tO\nconvulsant\tO\nand\tO\nsensitizing\tO\nproperties\tO\nof\tO\ncocaine\tB-Chemical\nand\tO\nadd\tO\nto\tO\na\tO\ngrowing\tO\nliterature\tO\non\tO\ntheir\tO\npotential\tO\nuse\tO\nin\tO\nthe\tO\nmodulation\tO\nof\tO\neffects\tO\nof\tO\ndrugs\tO\nof\tO\nabuse\tO\n.\tO\n\nEffect\tO\nof\tO\nhumoral\tO\nmodulators\tO\nof\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nof\tO\nmice\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nhumoral\tO\nmodulators\tO\non\tO\nthe\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nof\tO\nmice\tO\nwas\tO\nstudied\tO\n.\tO\n\nThe\tO\nsubcutaneous\tO\nadministration\tO\nof\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nof\tO\nmorphine\tB-Chemical\n-\tO\nHC1\tO\nproduced\tO\na\tO\nmarked\tO\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nin\tO\nmice\tO\n.\tO\n\nThe\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tO\nhyperactivity\tB-Disease\nwas\tO\npotentiated\tO\nby\tO\nscopolamine\tB-Chemical\nand\tO\nattenuated\tO\nby\tO\nphysostigmine\tB-Chemical\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nboth\tO\nmethscopolamine\tB-Chemical\nand\tO\nneostigmine\tB-Chemical\n,\tO\nwhich\tO\ndo\tO\nnot\tO\npenetrate\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n,\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nhyperactivity\tB-Disease\nproduced\tO\nby\tO\nmorphine\tB-Chemical\n.\tO\n\nPretreatment\tO\nof\tO\nmice\tO\nwith\tO\nalpha\tB-Chemical\n-\tI-Chemical\nmethyltyrosine\tI-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\none\tO\nhour\tO\n)\tO\n,\tO\nan\tO\ninhibitor\tO\nof\tO\ntyrosine\tB-Chemical\nhydroxylase\tO\n,\tO\nsignificantly\tO\ndecreased\tO\nthe\tO\nactivity\tO\n-\tO\nincreasing\tO\neffects\tO\nof\tO\nmorphine\tB-Chemical\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\npretreatment\tO\nwith\tO\np\tB-Chemical\n-\tI-Chemical\nchlorophenylalamine\tI-Chemical\n(\tO\n3\tO\nX\tO\n320\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\n24\tO\nhr\tO\n)\tO\n,\tO\na\tO\nserotonin\tB-Chemical\ndepletor\tO\n,\tO\ncaused\tO\nno\tO\nsignificant\tO\nchange\tO\nin\tO\nthe\tO\nhyperactivity\tB-Disease\n.\tO\n\n"
  },
  {
    "path": "dataset/BC5CDR/trigger_20.txt",
    "content": "Selegiline\tB-Chemical\n-\tO\ninduced\tT-1\npostural\tO\nhypotension\tO\nin\tO\nParkinson\tO\n'\tO\ns\tO\ndisease\tO\n:\tO\na\tO\nlongitudinal\tO\nstudy\tO\non\tO\nthe\tO\neffects\tT-0\nof\tT-0\ndrug\tO\nwithdrawal\tO\n.\tO\n\nSelegiline\tO\n-\tO\ninduced\tT-0\npostural\tB-Disease\nhypotension\tI-Disease\nin\tO\nParkinson\tO\n'\tO\ns\tO\ndisease\tO\n:\tO\na\tO\nlongitudinal\tO\nstudy\tO\non\tO\nthe\tO\neffects\tO\nof\tO\ndrug\tO\nwithdrawal\tO\n.\tO\n\nSelegiline\tO\n-\tO\ninduced\tT-1\npostural\tO\nhypotension\tO\nin\tT-0\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n:\tO\na\tO\nlongitudinal\tO\nstudy\tO\non\tO\nthe\tO\neffects\tO\nof\tO\ndrug\tO\nwithdrawal\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nUnited\tO\nKingdom\tO\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\nDisease\tI-Disease\nResearch\tO\nGroup\tO\n(\tO\nUKPDRG\tO\n)\tO\ntrial\tO\nfound\tO\nan\tO\nincreased\tT-1\nmortality\tT-1\nin\tT-1\npatients\tT-1\nwith\tO\nParkinson\tO\n'\tO\ns\tO\ndisease\tO\n(\tO\nPD\tO\n)\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tT-0\nmg\tT-0\nselegiline\tO\nper\tO\nday\tO\nand\tO\nL\tO\n-\tO\ndopa\tO\ncompared\tO\nwith\tO\nthose\tO\ntaking\tO\nL\tO\n-\tO\ndopa\tO\nalone\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nUnited\tO\nKingdom\tO\nParkinson\tO\n'\tO\ns\tO\nDisease\tO\nResearch\tO\nGroup\tO\n(\tO\nUKPDRG\tO\n)\tO\ntrial\tO\nfound\tO\nan\tO\nincreased\tT-0\nmortality\tT-1\nin\tO\npatients\tT-2\nwith\tT-2\nParkinson\tB-Disease\n'\tI-Disease\ns\tI-Disease\ndisease\tI-Disease\n(\tO\nPD\tO\n)\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tO\nmg\tO\nselegiline\tO\nper\tO\nday\tO\nand\tO\nL\tO\n-\tO\ndopa\tO\ncompared\tO\nwith\tO\nthose\tO\ntaking\tO\nL\tO\n-\tO\ndopa\tO\nalone\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nUnited\tO\nKingdom\tO\nParkinson\tO\n'\tO\ns\tO\nDisease\tO\nResearch\tO\nGroup\tO\n(\tO\nUKPDRG\tO\n)\tO\ntrial\tO\nfound\tO\nan\tO\nincreased\tO\nmortality\tO\nin\tT-0\npatients\tT-0\nwith\tT-0\nParkinson\tO\n'\tO\ns\tO\ndisease\tO\n(\tO\nPD\tB-Disease\n)\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tO\nmg\tO\nselegiline\tO\nper\tO\nday\tO\nand\tO\nL\tO\n-\tO\ndopa\tO\ncompared\tO\nwith\tO\nthose\tO\ntaking\tO\nL\tO\n-\tO\ndopa\tO\nalone\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nUnited\tO\nKingdom\tO\nParkinson\tO\n'\tO\ns\tO\nDisease\tO\nResearch\tO\nGroup\tO\n(\tO\nUKPDRG\tO\n)\tO\ntrial\tO\nfound\tO\nan\tO\nincreased\tO\nmortality\tO\nin\tO\npatients\tO\nwith\tO\nParkinson\tO\n'\tO\ns\tO\ndisease\tO\n(\tO\nPD\tO\n)\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tT-0\nmg\tT-0\nselegiline\tB-Chemical\nper\tO\nday\tO\nand\tO\nL\tO\n-\tO\ndopa\tO\ncompared\tO\nwith\tO\nthose\tO\ntaking\tO\nL\tO\n-\tO\ndopa\tO\nalone\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nUnited\tO\nKingdom\tO\nParkinson\tO\n'\tO\ns\tO\nDisease\tO\nResearch\tO\nGroup\tO\n(\tO\nUKPDRG\tO\n)\tO\ntrial\tO\nfound\tO\nan\tO\nincreased\tT-0\nmortality\tO\nin\tO\npatients\tO\nwith\tO\nParkinson\tO\n'\tO\ns\tO\ndisease\tO\n(\tO\nPD\tO\n)\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tO\nmg\tO\nselegiline\tO\nper\tO\nday\tO\nand\tT-2\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\ncompared\tT-1\nwith\tT-1\nthose\tO\ntaking\tO\nL\tO\n-\tO\ndopa\tO\nalone\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nThe\tO\nUnited\tO\nKingdom\tO\nParkinson\tO\n'\tO\ns\tO\nDisease\tO\nResearch\tO\nGroup\tO\n(\tO\nUKPDRG\tO\n)\tO\ntrial\tO\nfound\tO\nan\tO\nincreased\tO\nmortality\tO\nin\tO\npatients\tO\nwith\tO\nParkinson\tO\n'\tO\ns\tO\ndisease\tO\n(\tO\nPD\tO\n)\tO\nrandomized\tO\nto\tO\nreceive\tO\n10\tO\nmg\tO\nselegiline\tO\nper\tO\nday\tO\nand\tO\nL\tO\n-\tO\ndopa\tO\ncompared\tO\nwith\tO\nthose\tO\ntaking\tT-1\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nalone\tT-0\n.\tO\n\nRecently\tO\n,\tO\nwe\tO\nfound\tT-4\nthat\tT-4\ntherapy\tT-1\nwith\tO\nselegiline\tB-Chemical\nand\tO\nL\tO\n-\tO\ndopa\tO\nwas\tT-0\nassociated\tT-5\nwith\tT-5\nselective\tO\nsystolic\tT-2\northostatic\tT-2\nhypotension\tT-2\nwhich\tO\nwas\tO\nabolished\tO\nby\tO\nwithdrawal\tT-3\nof\tT-3\nselegiline\tT-3\n.\tO\n\nRecently\tO\n,\tO\nwe\tO\nfound\tO\nthat\tO\ntherapy\tT-3\nwith\tT-3\nselegiline\tO\nand\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nwas\tT-2\nassociated\tT-2\nwith\tO\nselective\tO\nsystolic\tT-0\northostatic\tT-0\nhypotension\tT-0\nwhich\tO\nwas\tO\nabolished\tO\nby\tO\nwithdrawal\tT-1\nof\tT-1\nselegiline\tT-1\n.\tO\n\nRecently\tO\n,\tO\nwe\tO\nfound\tO\nthat\tO\ntherapy\tO\nwith\tO\nselegiline\tO\nand\tO\nL\tO\n-\tO\ndopa\tO\nwas\tO\nassociated\tT-1\nwith\tT-1\nselective\tO\nsystolic\tB-Disease\northostatic\tI-Disease\nhypotension\tI-Disease\nwhich\tT-0\nwas\tT-0\nabolished\tO\nby\tO\nwithdrawal\tO\nof\tO\nselegiline\tO\n.\tO\n\nRecently\tO\n,\tO\nwe\tO\nfound\tO\nthat\tO\ntherapy\tT-0\nwith\tO\nselegiline\tO\nand\tO\nL\tT-1\n-\tT-1\ndopa\tT-1\nwas\tO\nassociated\tO\nwith\tO\nselective\tO\nsystolic\tT-2\northostatic\tT-2\nhypotension\tT-2\nwhich\tO\nwas\tO\nabolished\tO\nby\tO\nwithdrawal\tT-3\nof\tT-3\nselegiline\tB-Chemical\n.\tO\n\nThe\tO\naims\tO\nof\tO\nthis\tO\nstudy\tO\nwere\tO\nto\tO\nconfirm\tO\nour\tO\nprevious\tO\nfindings\tO\nin\tO\na\tO\nseparate\tO\ncohort\tO\nof\tO\npatients\tT-0\nand\tO\nto\tO\ndetermine\tO\nthe\tO\ntime\tO\ncourse\tO\nof\tO\nthe\tO\ncardiovascular\tT-4\nconsequences\tT-4\nof\tT-4\nstopping\tT-4\nselegiline\tB-Chemical\nin\tT-3\nthe\tT-3\nexpectation\tT-3\nthat\tO\nthis\tO\nmight\tO\nshed\tO\nlight\tO\non\tO\nthe\tO\nmechanisms\tO\nby\tO\nwhich\tO\nthe\tO\ndrug\tO\ncauses\tO\northostatic\tO\nhypotension\tO\n.\tO\n\nThe\tO\naims\tO\nof\tO\nthis\tO\nstudy\tO\nwere\tO\nto\tO\nconfirm\tO\nour\tO\nprevious\tO\nfindings\tO\nin\tO\na\tO\nseparate\tO\ncohort\tT-2\nof\tT-2\npatients\tT-2\nand\tO\nto\tO\ndetermine\tO\nthe\tO\ntime\tO\ncourse\tO\nof\tO\nthe\tO\ncardiovascular\tO\nconsequences\tO\nof\tO\nstopping\tT-0\nselegiline\tO\nin\tO\nthe\tO\nexpectation\tO\nthat\tO\nthis\tO\nmight\tO\nshed\tO\nlight\tO\non\tO\nthe\tO\nmechanisms\tO\nby\tO\nwhich\tO\nthe\tO\ndrug\tO\ncauses\tT-1\northostatic\tB-Disease\nhypotension\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tT-4\ncardiovascular\tT-4\nresponses\tT-4\nto\tO\nstanding\tO\nand\tO\nhead\tO\n-\tO\nup\tO\ntilt\tO\nwere\tO\nstudied\tT-0\nrepeatedly\tT-3\nin\tT-3\nPD\tB-Disease\npatients\tT-2\nreceiving\tO\nselegiline\tO\nand\tO\nas\tO\nthe\tO\ndrug\tO\nwas\tO\nwithdrawn\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\ncardiovascular\tO\nresponses\tO\nto\tO\nstanding\tO\nand\tO\nhead\tO\n-\tO\nup\tO\ntilt\tO\nwere\tO\nstudied\tO\nrepeatedly\tO\nin\tO\nPD\tO\npatients\tT-2\nreceiving\tT-2\nselegiline\tB-Chemical\nand\tT-3\nas\tT-3\nthe\tT-3\ndrug\tT-3\nwas\tO\nwithdrawn\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHead\tO\n-\tO\nup\tO\ntilt\tO\ncaused\tT-2\nsystolic\tB-Disease\northostatic\tI-Disease\nhypotension\tI-Disease\nwhich\tT-3\nwas\tT-3\nmarked\tT-0\nin\tT-0\nsix\tO\nof\tO\n20\tO\nPD\tO\npatients\tT-1\non\tO\nselegiline\tO\n,\tO\none\tO\nof\tO\nwhom\tO\nlost\tO\nconsciousness\tO\nwith\tO\nunrecordable\tO\nblood\tO\npressures\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHead\tT-3\n-\tT-3\nup\tT-3\ntilt\tO\ncaused\tT-0\nsystolic\tT-4\northostatic\tT-4\nhypotension\tT-4\nwhich\tO\nwas\tO\nmarked\tO\nin\tO\nsix\tT-6\nof\tT-6\n20\tT-6\nPD\tB-Disease\npatients\tO\non\tO\nselegiline\tO\n,\tO\none\tO\nof\tO\nwhom\tO\nlost\tT-1\nconsciousness\tO\nwith\tO\nunrecordable\tT-2\nblood\tO\npressures\tO\n.\tT-5\n\nRESULTS\tO\n:\tO\nHead\tO\n-\tO\nup\tO\ntilt\tO\ncaused\tO\nsystolic\tO\northostatic\tO\nhypotension\tO\nwhich\tO\nwas\tO\nmarked\tO\nin\tO\nsix\tO\nof\tO\n20\tO\nPD\tO\npatients\tT-0\non\tT-0\nselegiline\tB-Chemical\n,\tO\none\tO\nof\tO\nwhom\tO\nlost\tO\nconsciousness\tO\nwith\tO\nunrecordable\tO\nblood\tO\npressures\tO\n.\tO\n\nA\tO\nlesser\tO\ndegree\tT-0\nof\tT-0\northostatic\tB-Disease\nhypotension\tI-Disease\noccurred\tT-1\nwith\tO\nstanding\tO\n.\tO\n\nOrthostatic\tB-Disease\nhypotension\tI-Disease\nwas\tO\nameliorated\tT-0\n4\tO\ndays\tO\nafter\tO\nwithdrawal\tO\nof\tO\nselegiline\tT-1\nand\tO\ntotally\tO\nabolished\tO\n7\tO\ndays\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tT-2\n.\tO\n\nOrthostatic\tT-0\nhypotension\tT-0\nwas\tO\nameliorated\tO\n4\tO\ndays\tO\nafter\tO\nwithdrawal\tT-1\nof\tO\nselegiline\tB-Chemical\nand\tO\ntotally\tO\nabolished\tO\n7\tO\ndays\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tT-2\n.\tO\n\nStopping\tT-0\nselegiline\tB-Chemical\nalso\tO\nsignificantly\tO\nreduced\tT-2\nthe\tO\nsupine\tO\nsystolic\tO\nand\tO\ndiastolic\tO\nblood\tO\npressures\tO\nconsistent\tO\nwith\tO\na\tO\npreviously\tO\nundescribed\tO\nsupine\tO\npressor\tO\naction\tT-1\n.\tO\n\nStopping\tT-0\nselegiline\tO\nalso\tO\nsignificantly\tO\nreduced\tB-Disease\nthe\tI-Disease\nsupine\tI-Disease\nsystolic\tI-Disease\nand\tI-Disease\ndiastolic\tI-Disease\nblood\tI-Disease\npressures\tI-Disease\nconsistent\tT-1\nwith\tT-1\na\tO\npreviously\tO\nundescribed\tO\nsupine\tO\npressor\tO\naction\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nstudy\tO\nconfirms\tO\nour\tO\nprevious\tO\nfinding\tT-1\nthat\tT-1\nselegiline\tB-Chemical\nin\tT-2\ncombination\tT-2\nwith\tO\nL\tT-0\n-\tT-0\ndopa\tT-0\nis\tO\nassociated\tO\nwith\tO\nselective\tO\northostatic\tO\nhypotension\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nstudy\tO\nconfirms\tO\nour\tO\nprevious\tO\nfinding\tO\nthat\tO\nselegiline\tT-2\nin\tO\ncombination\tT-1\nwith\tO\nL\tB-Chemical\n-\tI-Chemical\ndopa\tI-Chemical\nis\tT-0\nassociated\tT-0\nwith\tO\nselective\tT-3\northostatic\tT-3\nhypotension\tT-3\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nstudy\tO\nconfirms\tO\nour\tO\nprevious\tO\nfinding\tO\nthat\tO\nselegiline\tO\nin\tT-0\ncombination\tT-0\nwith\tT-0\nL\tO\n-\tO\ndopa\tO\nis\tO\nassociated\tT-1\nwith\tT-2\nselective\tT-2\northostatic\tB-Disease\nhypotension\tI-Disease\n.\tO\n\nThe\tO\npossibilities\tO\nthat\tO\nthese\tO\ncardiovascular\tT-2\nfindings\tT-2\nmight\tT-2\nbe\tT-2\nthe\tT-2\nresult\tT-2\nof\tT-2\nnon\tO\n-\tO\nselective\tO\ninhibition\tT-0\nof\tO\nmonoamine\tO\noxidase\tO\nor\tT-1\nof\tT-1\namphetamine\tB-Chemical\nand\tO\nmetamphetamine\tO\nare\tO\ndiscussed\tO\n.\tO\n\nThe\tO\npossibilities\tO\nthat\tO\nthese\tO\ncardiovascular\tO\nfindings\tO\nmight\tT-2\nbe\tT-2\nthe\tT-2\nresult\tT-2\nof\tT-2\nnon\tO\n-\tO\nselective\tO\ninhibition\tO\nof\tO\nmonoamine\tO\noxidase\tO\nor\tO\nof\tO\namphetamine\tO\nand\tT-0\nmetamphetamine\tB-Chemical\nare\tT-1\ndiscussed\tT-1\n.\tO\n\nThe\tO\nresults\tO\nhave\tO\nshown\tO\nthat\tO\nthe\tO\ndegradation\tO\nproduct\tT-0\np\tB-Chemical\n-\tI-Chemical\ncholoroaniline\tI-Chemical\nis\tT-1\nnot\tT-1\na\tO\nsignificant\tO\nfactor\tO\nin\tO\nchlorhexidine\tT-2\n-\tO\ndigluconate\tO\nassociated\tO\nerosive\tO\ncystitis\tO\n.\tO\n\nThe\tO\nresults\tO\nhave\tO\nshown\tO\nthat\tO\nthe\tO\ndegradation\tT-2\nproduct\tT-2\np\tO\n-\tO\ncholoroaniline\tO\nis\tO\nnot\tO\na\tO\nsignificant\tO\nfactor\tT-0\nin\tT-0\nchlorhexidine\tB-Chemical\n-\tI-Chemical\ndigluconate\tI-Chemical\nassociated\tT-1\nerosive\tO\ncystitis\tO\n.\tO\n\nThe\tO\nresults\tO\nhave\tO\nshown\tO\nthat\tO\nthe\tO\ndegradation\tO\nproduct\tO\np\tO\n-\tO\ncholoroaniline\tO\nis\tO\nnot\tO\na\tO\nsignificant\tO\nfactor\tO\nin\tO\nchlorhexidine\tO\n-\tO\ndigluconate\tO\nassociated\tO\nerosive\tT-0\ncystitis\tB-Disease\n.\tO\n\nA\tO\nhigh\tO\npercentage\tT-2\nof\tT-2\nkanamycin\tB-Chemical\n-\tO\ncolistin\tO\nand\tO\npovidone\tO\n-\tO\niodine\tO\nirrigations\tO\nwere\tO\nassociated\tT-0\nwith\tO\nerosive\tO\ncystitis\tO\nand\tO\nsuggested\tO\na\tO\npossible\tO\ncomplication\tO\nwith\tO\nhuman\tO\nusage\tT-1\n.\tO\n\nA\tO\nhigh\tO\npercentage\tO\nof\tO\nkanamycin\tT-2\n-\tT-2\ncolistin\tB-Chemical\nand\tT-3\npovidone\tT-3\n-\tO\niodine\tO\nirrigations\tO\nwere\tO\nassociated\tT-0\nwith\tO\nerosive\tO\ncystitis\tO\nand\tO\nsuggested\tO\na\tO\npossible\tO\ncomplication\tO\nwith\tO\nhuman\tO\nusage\tT-1\n.\tO\n\nA\tO\nhigh\tO\npercentage\tO\nof\tO\nkanamycin\tO\n-\tO\ncolistin\tT-3\nand\tT-3\npovidone\tB-Chemical\n-\tI-Chemical\niodine\tI-Chemical\nirrigations\tT-2\nwere\tO\nassociated\tO\nwith\tO\nerosive\tO\ncystitis\tO\nand\tO\nsuggested\tO\na\tO\npossible\tO\ncomplication\tO\nwith\tO\nhuman\tO\nusage\tT-0\n.\tO\n\nA\tO\nhigh\tO\npercentage\tO\nof\tO\nkanamycin\tO\n-\tO\ncolistin\tO\nand\tO\npovidone\tO\n-\tO\niodine\tO\nirrigations\tO\nwere\tO\nassociated\tT-0\nwith\tT-2\nerosive\tT-2\ncystitis\tB-Disease\nand\tT-3\nsuggested\tT-3\na\tO\npossible\tO\ncomplication\tO\nwith\tO\nhuman\tO\nusage\tO\n.\tO\n\nPicloxydine\tB-Chemical\nirrigations\tT-1\nappeared\tT-1\nto\tO\nhave\tO\na\tO\nlower\tO\nincidence\tO\nof\tO\nerosive\tO\ncystitis\tO\nbut\tO\nfurther\tO\nstudies\tO\nwould\tO\nhave\tO\nto\tO\nbe\tO\nperformed\tO\nbefore\tO\nit\tO\ncould\tO\nbe\tO\nrecommended\tO\nfor\tO\nuse\tO\nin\tO\nurological\tO\nprocedures\tO\n.\tO\n\nPicloxydine\tO\nirrigations\tO\nappeared\tO\nto\tO\nhave\tO\na\tO\nlower\tT-1\nincidence\tT-1\nof\tT-1\nerosive\tT-1\ncystitis\tB-Disease\nbut\tO\nfurther\tO\nstudies\tO\nwould\tO\nhave\tO\nto\tO\nbe\tO\nperformed\tO\nbefore\tO\nit\tO\ncould\tO\nbe\tO\nrecommended\tO\nfor\tO\nuse\tO\nin\tO\nurological\tO\nprocedures\tO\n.\tO\n\nEffects\tT-0\nof\tT-0\ntetrandrine\tB-Chemical\nand\tO\nfangchinoline\tO\non\tO\nexperimental\tO\nthrombosis\tO\nin\tO\nmice\tO\nand\tO\nhuman\tO\nplatelet\tO\naggregation\tO\n.\tO\n\nEffects\tT-1\nof\tT-1\ntetrandrine\tT-1\nand\tO\nfangchinoline\tB-Chemical\non\tO\nexperimental\tO\nthrombosis\tO\nin\tO\nmice\tO\nand\tO\nhuman\tO\nplatelet\tO\naggregation\tO\n.\tO\n\nEffects\tT-1\nof\tT-1\ntetrandrine\tO\nand\tO\nfangchinoline\tO\non\tO\nexperimental\tT-0\nthrombosis\tB-Disease\nin\tO\nmice\tO\nand\tO\nhuman\tO\nplatelet\tO\naggregation\tO\n.\tO\n\nEffects\tO\nof\tO\ntetrandrine\tO\nand\tO\nfangchinoline\tO\non\tO\nexperimental\tO\nthrombosis\tT-1\nin\tO\nmice\tO\nand\tO\nhuman\tT-0\nplatelet\tB-Disease\naggregation\tI-Disease\n.\tO\n\nTetrandrine\tO\n(\tO\nTET\tB-Chemical\n)\tO\nand\tO\nfangchinoline\tO\n(\tO\nFAN\tO\n)\tO\nare\tO\ntwo\tO\nnaturally\tO\noccurring\tO\nanalogues\tO\nwith\tT-0\na\tT-0\nbisbenzylisoquinoline\tO\nstructure\tO\n.\tO\n\nTetrandrine\tO\n(\tO\nTET\tO\n)\tO\nand\tT-0\nfangchinoline\tB-Chemical\n(\tO\nFAN\tO\n)\tO\nare\tO\ntwo\tO\nnaturally\tO\noccurring\tO\nanalogues\tO\nwith\tO\na\tO\nbisbenzylisoquinoline\tO\nstructure\tO\n.\tO\n\nTetrandrine\tO\n(\tO\nTET\tO\n)\tO\nand\tO\nfangchinoline\tT-1\n(\tO\nFAN\tB-Chemical\n)\tO\nare\tT-2\ntwo\tT-2\nnaturally\tT-2\noccurring\tT-2\nanalogues\tO\nwith\tO\na\tO\nbisbenzylisoquinoline\tO\nstructure\tO\n.\tO\n\nTetrandrine\tO\n(\tO\nTET\tO\n)\tO\nand\tO\nfangchinoline\tO\n(\tO\nFAN\tO\n)\tO\nare\tO\ntwo\tO\nnaturally\tO\noccurring\tT-0\nanalogues\tO\nwith\tO\na\tO\nbisbenzylisoquinoline\tB-Chemical\nstructure\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tT-1\nof\tT-1\nTET\tB-Chemical\nand\tO\nFAN\tO\non\tO\nthe\tO\nexperimental\tO\nthrombosis\tO\ninduced\tT-0\nby\tO\ncollagen\tO\nplus\tO\nepinephrine\tO\n(\tO\nEP\tO\n)\tO\nin\tO\nmice\tO\n,\tO\nand\tO\nplatelet\tO\naggregation\tO\nand\tO\nblood\tO\ncoagulation\tO\nin\tO\nvitro\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tT-0\neffects\tT-0\nof\tT-0\nTET\tO\nand\tO\nFAN\tB-Chemical\non\tO\nthe\tO\nexperimental\tO\nthrombosis\tO\ninduced\tO\nby\tO\ncollagen\tO\nplus\tO\nepinephrine\tO\n(\tO\nEP\tO\n)\tO\nin\tO\nmice\tO\n,\tO\nand\tO\nplatelet\tO\naggregation\tO\nand\tO\nblood\tO\ncoagulation\tO\nin\tO\nvitro\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\nTET\tO\nand\tO\nFAN\tO\non\tT-2\nthe\tT-2\nexperimental\tT-2\nthrombosis\tB-Disease\ninduced\tT-1\nby\tT-1\ncollagen\tO\nplus\tO\nepinephrine\tO\n(\tO\nEP\tO\n)\tO\nin\tO\nmice\tO\n,\tO\nand\tO\nplatelet\tO\naggregation\tO\nand\tO\nblood\tO\ncoagulation\tO\nin\tO\nvitro\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\nTET\tO\nand\tO\nFAN\tO\non\tO\nthe\tO\nexperimental\tO\nthrombosis\tO\ninduced\tT-1\nby\tT-1\ncollagen\tO\nplus\tO\nepinephrine\tB-Chemical\n(\tO\nEP\tO\n)\tO\nin\tO\nmice\tO\n,\tO\nand\tO\nplatelet\tO\naggregation\tO\nand\tO\nblood\tO\ncoagulation\tO\nin\tO\nvitro\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tT-2\nof\tT-2\nTET\tO\nand\tO\nFAN\tO\non\tO\nthe\tO\nexperimental\tO\nthrombosis\tO\ninduced\tT-3\nby\tT-3\ncollagen\tO\nplus\tO\nepinephrine\tO\n(\tO\nEP\tB-Chemical\n)\tO\nin\tT-1\nmice\tT-1\n,\tO\nand\tO\nplatelet\tO\naggregation\tO\nand\tO\nblood\tO\ncoagulation\tO\nin\tO\nvitro\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\nTET\tO\nand\tO\nFAN\tO\non\tO\nthe\tO\nexperimental\tO\nthrombosis\tO\ninduced\tT-0\nby\tO\ncollagen\tO\nplus\tO\nepinephrine\tO\n(\tO\nEP\tO\n)\tO\nin\tO\nmice\tO\n,\tO\nand\tT-1\nplatelet\tB-Disease\naggregation\tI-Disease\nand\tT-2\nblood\tO\ncoagulation\tO\nin\tO\nvitro\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\nundertaken\tO\nto\tO\ninvestigate\tO\nthe\tO\neffects\tO\nof\tO\nTET\tO\nand\tO\nFAN\tO\non\tO\nthe\tO\nexperimental\tO\nthrombosis\tO\ninduced\tT-0\nby\tT-0\ncollagen\tO\nplus\tO\nepinephrine\tO\n(\tO\nEP\tO\n)\tO\nin\tO\nmice\tO\n,\tO\nand\tO\nplatelet\tO\naggregation\tO\nand\tT-1\nblood\tB-Disease\ncoagulation\tI-Disease\nin\tO\nvitro\tO\n.\tO\n\nIn\tO\nthe\tO\nin\tO\nvivo\tO\nstudy\tO\n,\tO\nthe\tO\nadministration\tT-2\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nof\tT-0\nTET\tB-Chemical\nand\tT-1\nFAN\tO\nin\tO\nmice\tO\nshowed\tO\nthe\tO\ninhibition\tT-3\nof\tO\nthrombosis\tO\nby\tO\n55\tO\n%\tO\nand\tO\n35\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nwhile\tO\nacetylsalicylic\tO\nacid\tO\n(\tO\nASA\tO\n,\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\na\tO\npositive\tO\ncontrol\tO\n,\tO\nshowed\tO\nonly\tO\n30\tO\n%\tO\ninhibition\tT-4\n.\tO\n\nIn\tO\nthe\tO\nin\tO\nvivo\tO\nstudy\tO\n,\tO\nthe\tO\nadministration\tT-2\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nof\tO\nTET\tO\nand\tO\nFAN\tB-Chemical\nin\tO\nmice\tO\nshowed\tO\nthe\tO\ninhibition\tT-3\nof\tO\nthrombosis\tT-1\nby\tO\n55\tO\n%\tO\nand\tO\n35\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nwhile\tO\nacetylsalicylic\tO\nacid\tO\n(\tO\nASA\tO\n,\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\na\tO\npositive\tO\ncontrol\tO\n,\tO\nshowed\tO\nonly\tO\n30\tO\n%\tO\ninhibition\tO\n.\tO\n\nIn\tO\nthe\tO\nin\tO\nvivo\tO\nstudy\tO\n,\tO\nthe\tO\nadministration\tT-0\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nof\tO\nTET\tO\nand\tO\nFAN\tO\nin\tO\nmice\tO\nshowed\tO\nthe\tO\ninhibition\tT-2\nof\tO\nthrombosis\tB-Disease\nby\tO\n55\tO\n%\tO\nand\tO\n35\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nwhile\tO\nacetylsalicylic\tO\nacid\tO\n(\tO\nASA\tO\n,\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\na\tO\npositive\tO\ncontrol\tO\n,\tO\nshowed\tO\nonly\tO\n30\tO\n%\tO\ninhibition\tT-1\n.\tO\n\nIn\tO\nthe\tO\nin\tO\nvivo\tO\nstudy\tO\n,\tO\nthe\tO\nadministration\tT-2\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nof\tO\nTET\tO\nand\tO\nFAN\tO\nin\tO\nmice\tO\nshowed\tO\nthe\tO\ninhibition\tT-0\nof\tO\nthrombosis\tO\nby\tO\n55\tO\n%\tO\nand\tO\n35\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nwhile\tO\nacetylsalicylic\tB-Chemical\nacid\tI-Chemical\n(\tO\nASA\tO\n,\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\na\tO\npositive\tO\ncontrol\tO\n,\tO\nshowed\tO\nonly\tO\n30\tO\n%\tO\ninhibition\tT-1\n.\tO\n\nIn\tO\nthe\tO\nin\tO\nvivo\tO\nstudy\tO\n,\tO\nthe\tT-0\nadministration\tT-0\n(\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\nof\tO\nTET\tO\nand\tO\nFAN\tO\nin\tO\nmice\tO\nshowed\tO\nthe\tO\ninhibition\tT-1\nof\tT-1\nthrombosis\tO\nby\tO\n55\tO\n%\tO\nand\tO\n35\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nwhile\tO\nacetylsalicylic\tO\nacid\tO\n(\tO\nASA\tB-Chemical\n,\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n,\tO\ni\tO\n.\tO\np\tO\n.\tO\n)\tO\n,\tO\na\tO\npositive\tO\ncontrol\tO\n,\tO\nshowed\tO\nonly\tO\n30\tO\n%\tO\ninhibition\tO\n.\tO\n\nIn\tO\nthe\tO\nvitro\tO\nhuman\tO\nplatelet\tB-Disease\naggregations\tI-Disease\ninduced\tT-2\nby\tO\nthe\tO\nagonists\tO\nused\tT-0\nin\tO\ntests\tO\n,\tO\nTET\tO\nand\tO\nFAN\tO\nshowed\tT-3\nthe\tO\ninhibitions\tT-1\ndose\tO\ndependently\tO\n.\tO\n\nIn\tO\nthe\tO\nvitro\tO\nhuman\tO\nplatelet\tO\naggregations\tO\ninduced\tT-0\nby\tT-0\nthe\tO\nagonists\tO\nused\tO\nin\tO\ntests\tO\n,\tO\nTET\tB-Chemical\nand\tT-1\nFAN\tO\nshowed\tO\nthe\tO\ninhibitions\tO\ndose\tO\ndependently\tO\n.\tO\n\nIn\tO\nthe\tO\nvitro\tO\nhuman\tO\nplatelet\tO\naggregations\tO\ninduced\tT-1\nby\tO\nthe\tO\nagonists\tO\nused\tO\nin\tO\ntests\tO\n,\tO\nTET\tO\nand\tO\nFAN\tB-Chemical\nshowed\tT-0\nthe\tO\ninhibitions\tT-2\ndose\tO\ndependently\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nneither\tT-0\nTET\tB-Chemical\nnor\tO\nFAN\tO\nshowed\tO\nany\tO\nanticoagulation\tO\nactivities\tO\nin\tO\nthe\tO\nmeasurement\tO\nof\tO\nthe\tO\nactivated\tO\npartial\tO\nthromboplastin\tO\ntime\tO\n(\tO\nAPTT\tO\n)\tO\n,\tO\nprothrombin\tO\ntime\tO\n(\tO\nPT\tO\n)\tO\nand\tO\nthrombin\tO\ntime\tO\n(\tO\nTT\tO\n)\tO\nusing\tO\nhuman\tO\n-\tO\ncitrated\tO\nplasma\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nneither\tT-0\nTET\tO\nnor\tO\nFAN\tB-Chemical\nshowed\tT-2\nany\tO\nanticoagulation\tO\nactivities\tO\nin\tO\nthe\tO\nmeasurement\tO\nof\tO\nthe\tO\nactivated\tO\npartial\tO\nthromboplastin\tO\ntime\tO\n(\tO\nAPTT\tO\n)\tO\n,\tO\nprothrombin\tO\ntime\tO\n(\tO\nPT\tO\n)\tO\nand\tO\nthrombin\tO\ntime\tO\n(\tO\nTT\tO\n)\tO\nusing\tO\nhuman\tO\n-\tO\ncitrated\tO\nplasma\tO\n.\tO\n\nThese\tO\nresults\tT-0\nsuggest\tT-1\nthat\tT-1\nantithrombosis\tO\nof\tO\nTET\tB-Chemical\nand\tO\nFAN\tO\nin\tO\nmice\tO\nmay\tO\nbe\tO\nmainly\tO\nrelated\tO\nto\tO\nthe\tO\nantiplatelet\tO\naggregation\tO\nactivities\tO\n.\tO\n\nThese\tO\nresults\tO\nsuggest\tT-0\nthat\tT-0\nantithrombosis\tO\nof\tO\nTET\tO\nand\tO\nFAN\tB-Chemical\nin\tO\nmice\tO\nmay\tO\nbe\tO\nmainly\tO\nrelated\tO\nto\tO\nthe\tO\nantiplatelet\tO\naggregation\tO\nactivities\tO\n.\tO\n\nAngioedema\tB-Disease\ndue\tT-0\nto\tT-0\nACE\tO\ninhibitors\tO\n:\tO\ncommon\tO\nand\tO\ninadequately\tO\ndiagnosed\tT-1\n.\tO\n\nAngioedema\tO\ndue\tT-1\nto\tT-1\nACE\tB-Chemical\ninhibitors\tI-Chemical\n:\tO\ncommon\tO\nand\tO\ninadequately\tO\ndiagnosed\tT-0\n.\tO\n\nThe\tO\nestimated\tO\nincidence\tT-0\nof\tT-0\nangioedema\tB-Disease\nduring\tO\nangiotensin\tO\n-\tO\nconverting\tO\nenzyme\tO\n(\tO\nACE\tO\n)\tO\ninhibitor\tO\ntreatment\tO\nis\tO\nbetween\tO\n1\tO\nand\tO\n7\tO\nper\tO\nthousand\tO\npatients\tO\n.\tO\n\nThe\tO\nestimated\tO\nincidence\tO\nof\tO\nangioedema\tO\nduring\tT-0\nangiotensin\tB-Chemical\n-\tI-Chemical\nconverting\tI-Chemical\nenzyme\tI-Chemical\n(\tI-Chemical\nACE\tI-Chemical\n)\tI-Chemical\ninhibitor\tI-Chemical\ntreatment\tT-1\nis\tO\nbetween\tO\n1\tO\nand\tO\n7\tO\nper\tO\nthousand\tO\npatients\tO\n.\tO\n\nCocaine\tB-Chemical\n-\tT-1\ninduced\tT-1\nmood\tO\ndisorder\tO\n:\tO\nprevalence\tO\nrates\tO\nand\tO\npsychiatric\tO\nsymptoms\tO\nin\tO\nan\tO\noutpatient\tO\ncocaine\tO\n-\tO\ndependent\tO\nsample\tO\n.\tO\n\nCocaine\tO\n-\tO\ninduced\tT-1\nmood\tB-Disease\ndisorder\tI-Disease\n:\tT-0\nprevalence\tT-0\nrates\tT-0\nand\tO\npsychiatric\tO\nsymptoms\tO\nin\tO\nan\tO\noutpatient\tO\ncocaine\tO\n-\tO\ndependent\tO\nsample\tO\n.\tO\n\nCocaine\tO\n-\tO\ninduced\tT-2\nmood\tO\ndisorder\tO\n:\tO\nprevalence\tT-3\nrates\tT-3\nand\tT-0\npsychiatric\tB-Disease\nsymptoms\tT-1\nin\tT-1\nan\tO\noutpatient\tO\ncocaine\tO\n-\tO\ndependent\tO\nsample\tO\n.\tO\n\nCocaine\tO\n-\tO\ninduced\tT-0\nmood\tO\ndisorder\tO\n:\tO\nprevalence\tO\nrates\tO\nand\tO\npsychiatric\tO\nsymptoms\tT-1\nin\tO\nan\tO\noutpatient\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tT-2\nsample\tO\n.\tO\n\nThis\tO\npaper\tO\nattempts\tO\nto\tO\nexamine\tO\nand\tO\ncompare\tO\nprevalence\tT-1\nrates\tT-1\nand\tO\nsymptom\tT-2\npatterns\tT-2\nof\tT-2\nDSM\tO\nsubstance\tT-3\n-\tT-3\ninduced\tT-3\nand\tT-0\nother\tT-0\nmood\tB-Disease\ndisorders\tI-Disease\n.\tO\n\n243\tO\ncocaine\tB-Chemical\n-\tO\ndependent\tT-1\noutpatients\tT-1\nwith\tO\ncocaine\tO\n-\tO\ninduced\tO\nmood\tO\ndisorder\tO\n(\tO\nCIMD\tO\n)\tO\n,\tO\nother\tO\nmood\tO\ndisorders\tO\n,\tO\nor\tO\nno\tO\nmood\tO\ndisorder\tO\nwere\tO\ncompared\tO\non\tO\nmeasures\tT-0\nof\tT-0\npsychiatric\tO\nsymptoms\tO\n.\tO\n\n243\tO\ncocaine\tO\n-\tO\ndependent\tO\noutpatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tT-0\nmood\tO\ndisorder\tO\n(\tO\nCIMD\tO\n)\tO\n,\tO\nother\tO\nmood\tO\ndisorders\tO\n,\tO\nor\tO\nno\tO\nmood\tO\ndisorder\tO\nwere\tO\ncompared\tO\non\tO\nmeasures\tO\nof\tO\npsychiatric\tO\nsymptoms\tO\n.\tO\n\n243\tO\ncocaine\tO\n-\tO\ndependent\tO\noutpatients\tO\nwith\tO\ncocaine\tO\n-\tO\ninduced\tT-0\nmood\tB-Disease\ndisorder\tI-Disease\n(\tO\nCIMD\tO\n)\tO\n,\tO\nother\tO\nmood\tO\ndisorders\tO\n,\tO\nor\tO\nno\tO\nmood\tO\ndisorder\tO\nwere\tO\ncompared\tO\non\tO\nmeasures\tO\nof\tO\npsychiatric\tO\nsymptoms\tO\n.\tO\n\n243\tO\ncocaine\tO\n-\tO\ndependent\tO\noutpatients\tO\nwith\tO\ncocaine\tO\n-\tO\ninduced\tT-0\nmood\tO\ndisorder\tO\n(\tO\nCIMD\tB-Disease\n)\tO\n,\tO\nother\tO\nmood\tO\ndisorders\tO\n,\tO\nor\tO\nno\tO\nmood\tO\ndisorder\tO\nwere\tO\ncompared\tO\non\tO\nmeasures\tO\nof\tO\npsychiatric\tO\nsymptoms\tO\n.\tO\n\n243\tO\ncocaine\tO\n-\tO\ndependent\tO\noutpatients\tO\nwith\tO\ncocaine\tO\n-\tO\ninduced\tO\nmood\tO\ndisorder\tO\n(\tO\nCIMD\tO\n)\tO\n,\tO\nother\tT-0\nmood\tB-Disease\ndisorders\tI-Disease\n,\tO\nor\tO\nno\tO\nmood\tO\ndisorder\tO\nwere\tO\ncompared\tO\non\tO\nmeasures\tO\nof\tO\npsychiatric\tO\nsymptoms\tO\n.\tT-1\n\n243\tO\ncocaine\tO\n-\tO\ndependent\tO\noutpatients\tO\nwith\tO\ncocaine\tO\n-\tO\ninduced\tT-2\nmood\tO\ndisorder\tO\n(\tO\nCIMD\tO\n)\tO\n,\tO\nother\tO\nmood\tO\ndisorders\tO\n,\tO\nor\tO\nno\tO\nmood\tB-Disease\ndisorder\tI-Disease\nwere\tO\ncompared\tT-1\non\tO\nmeasures\tO\nof\tO\npsychiatric\tO\nsymptoms\tO\n.\tO\n\n243\tO\ncocaine\tO\n-\tO\ndependent\tO\noutpatients\tO\nwith\tO\ncocaine\tO\n-\tO\ninduced\tT-0\nmood\tO\ndisorder\tO\n(\tO\nCIMD\tO\n)\tO\n,\tO\nother\tO\nmood\tO\ndisorders\tO\n,\tO\nor\tO\nno\tO\nmood\tO\ndisorder\tO\nwere\tO\ncompared\tT-1\non\tT-1\nmeasures\tT-2\nof\tT-2\npsychiatric\tB-Disease\nsymptoms\tT-3\n.\tO\n\nThe\tO\nprevalence\tT-1\nrate\tT-1\nfor\tT-1\nCIMD\tB-Disease\nwas\tO\n12\tO\n%\tO\nat\tO\nbaseline\tO\n.\tO\n\nIntroduction\tT-0\nof\tT-0\nthe\tO\nDSM\tO\n-\tO\nIV\tT-2\ndiagnosis\tT-2\nof\tT-2\nCIMD\tB-Disease\ndid\tO\nnot\tO\nsubstantially\tO\naffect\tT-1\nrates\tO\nof\tO\nthe\tO\nother\tO\ndepressive\tO\ndisorders\tO\n.\tO\n\nIntroduction\tT-0\nof\tO\nthe\tO\nDSM\tO\n-\tO\nIV\tO\ndiagnosis\tO\nof\tO\nCIMD\tO\ndid\tO\nnot\tO\nsubstantially\tO\naffect\tT-1\nrates\tO\nof\tO\nthe\tO\nother\tO\ndepressive\tB-Disease\ndisorders\tI-Disease\n.\tO\n\nPatients\tT-2\nwith\tT-2\nCIMD\tB-Disease\nhad\tT-1\nsymptom\tT-1\nseverity\tO\nlevels\tO\nbetween\tO\nthose\tO\nof\tO\npatients\tO\nwith\tO\nand\tO\nwithout\tO\na\tO\nmood\tO\ndisorder\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nsome\tO\nvalidity\tO\nfor\tO\nthe\tO\nnew\tO\nDSM\tO\n-\tO\nIV\tO\ndiagnosis\tT-1\nof\tT-1\nCIMD\tB-Disease\n,\tO\nbut\tO\nalso\tO\nsuggest\tO\nthat\tO\nit\tO\nrequires\tO\nfurther\tO\nspecification\tO\nand\tO\nreplication\tO\n.\tO\n\nEffect\tT-0\nof\tT-0\nfucoidan\tB-Chemical\ntreatment\tT-1\non\tO\ncollagenase\tO\n-\tO\ninduced\tT-2\nintracerebral\tO\nhemorrhage\tO\nin\tO\nrats\tO\n.\tO\n\nEffect\tO\nof\tO\nfucoidan\tO\ntreatment\tT-0\non\tO\ncollagenase\tO\n-\tO\ninduced\tT-1\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nInflammatory\tO\ncells\tO\nare\tO\npostulated\tO\nto\tO\nmediate\tT-0\nsome\tO\nof\tO\nthe\tO\nbrain\tB-Disease\ndamage\tI-Disease\nfollowing\tO\nischemic\tO\nstroke\tO\n.\tO\n\nInflammatory\tO\ncells\tO\nare\tO\npostulated\tO\nto\tO\nmediate\tO\nsome\tO\nof\tO\nthe\tO\nbrain\tO\ndamage\tO\nfollowing\tT-0\nischemic\tB-Disease\nstroke\tI-Disease\n.\tO\n\nIntracerebral\tB-Disease\nhemorrhage\tI-Disease\nis\tT-0\nassociated\tT-1\nwith\tT-1\nmore\tO\ninflammation\tO\nthan\tO\nischemic\tO\nstroke\tO\n.\tO\n\nIntracerebral\tO\nhemorrhage\tT-0\nis\tO\nassociated\tT-2\nwith\tO\nmore\tO\ninflammation\tB-Disease\nthan\tO\nischemic\tT-1\nstroke\tO\n.\tO\n\nIntracerebral\tO\nhemorrhage\tO\nis\tO\nassociated\tT-0\nwith\tT-0\nmore\tO\ninflammation\tO\nthan\tT-1\nischemic\tB-Disease\nstroke\tI-Disease\n.\tO\n\nWe\tO\ntested\tO\nthe\tO\nsulfated\tO\npolysaccharide\tO\nfucoidan\tB-Chemical\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nreduce\tT-1\ninflammatory\tO\nbrain\tO\ndamage\tO\n,\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nintracerebral\tO\nhemorrhage\tO\ninduced\tT-0\nby\tO\ninjection\tO\nof\tO\nbacterial\tO\ncollagenase\tO\ninto\tO\nthe\tO\ncaudate\tO\nnucleus\tO\n.\tO\n\nWe\tO\ntested\tO\nthe\tO\nsulfated\tO\npolysaccharide\tO\nfucoidan\tO\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nreduce\tT-0\ninflammatory\tO\nbrain\tB-Disease\ndamage\tI-Disease\n,\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\nintracerebral\tO\nhemorrhage\tO\ninduced\tO\nby\tO\ninjection\tO\nof\tO\nbacterial\tO\ncollagenase\tO\ninto\tO\nthe\tO\ncaudate\tO\nnucleus\tO\n.\tO\n\nWe\tO\ntested\tO\nthe\tO\nsulfated\tO\npolysaccharide\tO\nfucoidan\tO\n,\tO\nwhich\tO\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nreduce\tO\ninflammatory\tO\nbrain\tO\ndamage\tO\n,\tO\nin\tO\na\tO\nrat\tO\nmodel\tT-0\nof\tT-0\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\ninduced\tT-1\nby\tT-1\ninjection\tO\nof\tO\nbacterial\tO\ncollagenase\tO\ninto\tO\nthe\tO\ncaudate\tO\nnucleus\tO\n.\tO\n\nRats\tO\nwere\tO\ntreated\tT-1\nwith\tT-0\nseven\tO\nday\tO\nintravenous\tO\ninfusion\tT-2\nof\tO\nfucoidan\tB-Chemical\n(\tO\n30\tO\nmicrograms\tO\nh\tO\n-\tO\n1\tO\n)\tO\nor\tO\nvehicle\tO\n.\tO\n\nThe\tT-0\nhematoma\tB-Disease\nwas\tT-1\nassessed\tT-1\nin\tO\nvivo\tO\nby\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\n.\tO\n\nFucoidan\tB-Chemical\n-\tT-1\ntreated\tT-1\nrats\tT-1\nexhibited\tO\nevidence\tO\nof\tO\nimpaired\tO\nblood\tO\nclotting\tO\nand\tO\nhemodilution\tO\n,\tO\nhad\tO\nlarger\tO\nhematomas\tO\n,\tO\nand\tO\ntended\tO\nto\tO\nhave\tO\nless\tO\ninflammation\tO\nin\tO\nthe\tO\nvicinity\tO\nof\tO\nthe\tO\nhematoma\tO\nafter\tO\nthree\tO\ndays\tO\n.\tO\n\nFucoidan\tO\n-\tO\ntreated\tO\nrats\tO\nexhibited\tT-0\nevidence\tO\nof\tO\nimpaired\tB-Disease\nblood\tI-Disease\nclotting\tI-Disease\nand\tO\nhemodilution\tO\n,\tO\nhad\tO\nlarger\tO\nhematomas\tO\n,\tO\nand\tO\ntended\tT-1\nto\tO\nhave\tO\nless\tO\ninflammation\tO\nin\tO\nthe\tO\nvicinity\tO\nof\tO\nthe\tO\nhematoma\tO\nafter\tO\nthree\tO\ndays\tO\n.\tO\n\nFucoidan\tO\n-\tO\ntreated\tO\nrats\tO\nexhibited\tO\nevidence\tO\nof\tO\nimpaired\tO\nblood\tO\nclotting\tO\nand\tT-0\nhemodilution\tB-Disease\n,\tO\nhad\tO\nlarger\tO\nhematomas\tO\n,\tO\nand\tO\ntended\tO\nto\tO\nhave\tO\nless\tO\ninflammation\tO\nin\tO\nthe\tO\nvicinity\tO\nof\tO\nthe\tO\nhematoma\tO\nafter\tO\nthree\tO\ndays\tO\n.\tO\n\nFucoidan\tO\n-\tO\ntreated\tO\nrats\tO\nexhibited\tO\nevidence\tO\nof\tO\nimpaired\tO\nblood\tO\nclotting\tO\nand\tO\nhemodilution\tO\n,\tO\nhad\tT-0\nlarger\tT-0\nhematomas\tB-Disease\n,\tO\nand\tO\ntended\tO\nto\tO\nhave\tO\nless\tO\ninflammation\tO\nin\tO\nthe\tO\nvicinity\tO\nof\tO\nthe\tO\nhematoma\tO\nafter\tO\nthree\tO\ndays\tO\n.\tO\n\nFucoidan\tO\n-\tO\ntreated\tO\nrats\tO\nexhibited\tT-1\nevidence\tO\nof\tO\nimpaired\tO\nblood\tO\nclotting\tO\nand\tO\nhemodilution\tO\n,\tO\nhad\tO\nlarger\tO\nhematomas\tO\n,\tO\nand\tO\ntended\tO\nto\tT-0\nhave\tT-0\nless\tT-0\ninflammation\tB-Disease\nin\tO\nthe\tO\nvicinity\tO\nof\tO\nthe\tO\nhematoma\tO\nafter\tO\nthree\tO\ndays\tO\n.\tO\n\nThey\tO\nshowed\tO\nsignificantly\tO\nmore\tO\nrapid\tO\nimprovement\tT-2\nof\tO\nmotor\tO\nfunction\tO\nin\tO\nthe\tO\nfirst\tO\nweek\tO\nfollowing\tT-0\nhemorrhage\tB-Disease\nand\tT-1\nbetter\tO\nmemory\tO\nretention\tO\nin\tO\nthe\tO\npassive\tO\navoidance\tO\ntest\tO\n.\tO\n\nAcute\tT-1\nwhite\tB-Disease\nmatter\tI-Disease\nedema\tI-Disease\nand\tO\neventual\tO\nneuronal\tO\nloss\tO\nin\tO\nthe\tO\nstriatum\tO\nadjacent\tO\nto\tO\nthe\tO\nhematoma\tO\ndid\tO\nnot\tO\ndiffer\tT-0\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nAcute\tO\nwhite\tO\nmatter\tO\nedema\tO\nand\tO\neventual\tO\nneuronal\tO\nloss\tO\nin\tO\nthe\tO\nstriatum\tO\nadjacent\tT-0\nto\tT-0\nthe\tO\nhematoma\tB-Disease\ndid\tO\nnot\tO\ndiffer\tO\nbetween\tO\nthe\tO\ntwo\tO\ngroups\tO\n.\tO\n\nInvestigation\tO\nof\tO\nmore\tO\nspecific\tO\nanti\tO\n-\tO\ninflammatory\tO\nagents\tO\nand\tO\nhemodiluting\tO\nagents\tO\nare\tO\nwarranted\tT-1\nin\tT-1\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n.\tO\n\nAccumulation\tT-0\nof\tO\natracurium\tB-Chemical\nin\tO\nthe\tO\nintravenous\tO\nline\tO\nled\tO\nto\tO\nrecurarization\tO\nafter\tO\nflushing\tO\nthe\tO\nline\tO\nin\tO\nthe\tO\nrecovery\tO\nroom\tO\n.\tO\n\nA\tT-0\nrespiratory\tB-Disease\narrest\tI-Disease\nwith\tT-1\nsevere\tO\ndesaturation\tO\nand\tO\nbradycardia\tO\noccurred\tT-2\n.\tO\n\nA\tO\nrespiratory\tO\narrest\tT-0\nwith\tO\nsevere\tT-2\ndesaturation\tB-Disease\nand\tO\nbradycardia\tO\noccurred\tT-1\n.\tO\n\nA\tO\nrespiratory\tO\narrest\tO\nwith\tO\nsevere\tO\ndesaturation\tO\nand\tO\nbradycardia\tB-Disease\noccurred\tT-0\n.\tO\n\nCircumstances\tO\nleading\tO\nto\tO\nthis\tO\nevent\tO\nand\tO\nthe\tO\nmechanisms\tT-0\nenabling\tT-0\na\tO\nneuromuscular\tB-Disease\nblockade\tI-Disease\nto\tO\noccur\tO\n,\tO\nfollowing\tO\nthe\tO\nadministration\tT-1\nof\tT-1\na\tO\nsmall\tO\ndose\tO\nof\tO\nrelaxant\tO\n,\tO\nare\tO\ndiscussed\tO\n.\tO\n\nThe\tO\nhaemodynamic\tO\neffects\tT-0\nof\tO\npropofol\tB-Chemical\nin\tO\ncombination\tT-1\nwith\tT-1\nephedrine\tO\nin\tO\nelderly\tO\npatients\tO\n(\tO\nASA\tO\ngroups\tO\n3\tO\nand\tO\n4\tO\n)\tO\n.\tO\n\nThe\tO\nhaemodynamic\tO\neffects\tO\nof\tO\npropofol\tO\nin\tT-0\ncombination\tT-0\nwith\tT-0\nephedrine\tB-Chemical\nin\tO\nelderly\tO\npatients\tO\n(\tO\nASA\tO\ngroups\tO\n3\tO\nand\tO\n4\tO\n)\tO\n.\tO\n\nThe\tO\nmarked\tO\nvasodilator\tO\nand\tO\nnegative\tO\ninotropic\tO\neffects\tT-1\nof\tT-1\npropofol\tB-Chemical\nare\tT-2\ndisadvantages\tT-2\nin\tO\nfrail\tO\nelderly\tO\npatients\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nadding\tO\ndifferent\tO\ndoses\tT-0\nof\tT-0\nephedrine\tB-Chemical\nto\tO\npropofol\tO\nin\tO\norder\tO\nto\tO\nobtund\tO\nthe\tO\nhypotensive\tO\nresponse\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nadding\tO\ndifferent\tO\ndoses\tT-1\nof\tO\nephedrine\tO\nto\tO\npropofol\tB-Chemical\nin\tT-0\norder\tT-0\nto\tT-0\nobtund\tT-2\nthe\tO\nhypotensive\tO\nresponse\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nadding\tT-2\ndifferent\tO\ndoses\tO\nof\tO\nephedrine\tO\nto\tO\npropofol\tO\nin\tO\norder\tO\nto\tO\nobtund\tT-0\nthe\tT-0\nhypotensive\tB-Disease\nresponse\tT-1\n.\tO\n\nThe\tO\nhaemodynamic\tO\neffects\tO\nof\tO\nadding\tO\n15\tO\n,\tO\n20\tO\nor\tO\n25\tT-0\nmg\tT-2\nof\tT-2\nephedrine\tB-Chemical\nto\tT-1\n200\tT-1\nmg\tT-1\nof\tO\npropofol\tO\nwere\tO\ncompared\tO\nto\tO\ncontrol\tO\nin\tO\n40\tO\nASA\tO\n3\tO\n/\tO\n4\tO\npatients\tO\nover\tO\n60\tO\nyears\tO\npresenting\tO\nfor\tO\ngenito\tO\n-\tO\nurinary\tO\nsurgery\tO\n.\tO\n\nThe\tO\nhaemodynamic\tO\neffects\tT-2\nof\tT-2\nadding\tO\n15\tO\n,\tO\n20\tO\nor\tO\n25\tO\nmg\tO\nof\tO\nephedrine\tO\nto\tO\n200\tT-1\nmg\tT-1\nof\tT-1\npropofol\tB-Chemical\nwere\tO\ncompared\tT-3\nto\tT-3\ncontrol\tO\nin\tO\n40\tO\nASA\tO\n3\tO\n/\tO\n4\tO\npatients\tO\nover\tO\n60\tO\nyears\tO\npresenting\tO\nfor\tO\ngenito\tO\n-\tO\nurinary\tO\nsurgery\tO\n.\tO\n\nThe\tO\naddition\tO\nof\tO\nephedrine\tB-Chemical\nto\tT-0\npropofol\tT-0\nappears\tO\nto\tO\nbe\tO\nan\tO\neffective\tO\nmethod\tO\nof\tO\nobtunding\tO\nthe\tO\nhypotensive\tO\nresponse\tO\nto\tO\npropofol\tO\nat\tO\nall\tO\ndoses\tO\nused\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nThe\tO\naddition\tO\nof\tO\nephedrine\tT-1\nto\tT-1\npropofol\tB-Chemical\nappears\tO\nto\tO\nbe\tO\nan\tO\neffective\tO\nmethod\tO\nof\tO\nobtunding\tO\nthe\tO\nhypotensive\tO\nresponse\tO\nto\tO\npropofol\tO\nat\tO\nall\tO\ndoses\tT-0\nused\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nThe\tO\naddition\tO\nof\tO\nephedrine\tO\nto\tO\npropofol\tO\nappears\tO\nto\tO\nbe\tO\nan\tO\neffective\tO\nmethod\tO\nof\tT-2\nobtunding\tT-2\nthe\tT-2\nhypotensive\tB-Disease\nresponse\tT-0\nto\tO\npropofol\tO\nat\tO\nall\tO\ndoses\tO\nused\tT-1\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nThe\tO\naddition\tO\nof\tO\nephedrine\tO\nto\tO\npropofol\tO\nappears\tO\nto\tO\nbe\tO\nan\tO\neffective\tO\nmethod\tO\nof\tO\nobtunding\tO\nthe\tO\nhypotensive\tO\nresponse\tT-1\nto\tT-1\npropofol\tB-Chemical\nat\tT-2\nall\tT-2\ndoses\tT-2\nused\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nHowever\tO\n,\tO\nmarked\tO\ntachycardia\tB-Disease\nassociated\tT-0\nwith\tT-0\nthe\tO\nuse\tO\nof\tO\nephedrine\tO\nin\tO\ncombination\tO\nwith\tO\npropofol\tO\noccurred\tT-1\nin\tT-1\nthe\tO\nmajority\tO\nof\tO\npatients\tO\n,\tO\noccasionally\tO\nreaching\tO\nhigh\tO\nlevels\tO\nin\tT-2\nindividual\tO\npatients\tT-3\n.\tO\n\nHowever\tO\n,\tO\nmarked\tO\ntachycardia\tO\nassociated\tO\nwith\tT-1\nthe\tT-1\nuse\tT-1\nof\tT-1\nephedrine\tB-Chemical\nin\tT-2\ncombination\tT-2\nwith\tT-2\npropofol\tO\noccurred\tO\nin\tO\nthe\tO\nmajority\tO\nof\tO\npatients\tO\n,\tO\noccasionally\tO\nreaching\tO\nhigh\tO\nlevels\tO\nin\tO\nindividual\tO\npatients\tO\n.\tO\n\nHowever\tO\n,\tO\nmarked\tO\ntachycardia\tO\nassociated\tT-0\nwith\tT-0\nthe\tO\nuse\tO\nof\tO\nephedrine\tO\nin\tO\ncombination\tT-1\nwith\tT-1\npropofol\tB-Chemical\noccurred\tT-2\nin\tT-2\nthe\tO\nmajority\tO\nof\tO\npatients\tO\n,\tO\noccasionally\tO\nreaching\tO\nhigh\tO\nlevels\tO\nin\tO\nindividual\tO\npatients\tO\n.\tO\n\nDue\tO\nto\tO\nthe\tO\nrisk\tT-0\nof\tT-0\nthis\tT-0\ntachycardia\tB-Disease\ninducing\tT-1\nmyocardial\tO\nischemia\tO\n,\tO\nwe\tO\nwould\tO\nnot\tO\nrecommend\tO\nthe\tO\nuse\tO\nin\tO\nelderly\tO\npatients\tO\nof\tO\nany\tO\nof\tO\nthe\tO\nephedrine\tO\n/\tO\npropofol\tO\n/\tO\nmixtures\tO\nstudied\tO\n.\tO\n\nDue\tO\nto\tO\nthe\tO\nrisk\tO\nof\tO\nthis\tO\ntachycardia\tO\ninducing\tT-1\nmyocardial\tB-Disease\nischemia\tI-Disease\n,\tO\nwe\tO\nwould\tO\nnot\tO\nrecommend\tO\nthe\tO\nuse\tO\nin\tO\nelderly\tO\npatients\tO\nof\tO\nany\tO\nof\tO\nthe\tO\nephedrine\tO\n/\tO\npropofol\tO\n/\tO\nmixtures\tO\nstudied\tO\n.\tO\n\nDue\tO\nto\tO\nthe\tO\nrisk\tO\nof\tO\nthis\tO\ntachycardia\tO\ninducing\tO\nmyocardial\tO\nischemia\tO\n,\tO\nwe\tT-1\nwould\tT-1\nnot\tT-1\nrecommend\tT-1\nthe\tO\nuse\tO\nin\tO\nelderly\tO\npatients\tO\nof\tO\nany\tT-0\nof\tT-0\nthe\tT-0\nephedrine\tB-Chemical\n/\tO\npropofol\tO\n/\tO\nmixtures\tO\nstudied\tO\n.\tO\n\nDue\tO\nto\tO\nthe\tO\nrisk\tT-0\nof\tT-0\nthis\tO\ntachycardia\tO\ninducing\tT-1\nmyocardial\tO\nischemia\tO\n,\tO\nwe\tO\nwould\tO\nnot\tT-2\nrecommend\tT-2\nthe\tO\nuse\tO\nin\tO\nelderly\tO\npatients\tO\nof\tO\nany\tO\nof\tO\nthe\tO\nephedrine\tO\n/\tO\npropofol\tB-Chemical\n/\tO\nmixtures\tO\nstudied\tO\n.\tO\n\nGemcitabine\tB-Chemical\nplus\tO\nvinorelbine\tO\nin\tO\nnonsmall\tO\ncell\tO\nlung\tO\ncarcinoma\tO\npatients\tO\nage\tO\n70\tO\nyears\tO\nor\tO\nolder\tO\nor\tO\npatients\tO\nwho\tO\ncannot\tT-0\nreceive\tT-0\ncisplatin\tO\n.\tO\n\nGemcitabine\tO\nplus\tO\nvinorelbine\tO\nin\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\npatients\tT-0\nage\tO\n70\tO\nyears\tO\nor\tO\nolder\tO\nor\tO\npatients\tO\nwho\tT-1\ncannot\tT-1\nreceive\tT-1\ncisplatin\tO\n.\tO\n\nGemcitabine\tO\nplus\tO\nvinorelbine\tO\nin\tO\nnonsmall\tO\ncell\tO\nlung\tO\ncarcinoma\tO\npatients\tO\nage\tO\n70\tO\nyears\tO\nor\tO\nolder\tO\nor\tO\npatients\tT-0\nwho\tT-0\ncannot\tT-0\nreceive\tT-0\ncisplatin\tB-Chemical\n.\tO\n\nBACKGROUND\tO\n:\tO\nAlthough\tO\nthe\tO\nprevalence\tT-0\nof\tT-1\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\n(\tO\nNSCLC\tO\n)\tO\nis\tO\nhigh\tO\namong\tO\nelderly\tO\npatients\tO\n,\tO\nfew\tO\ndata\tO\nare\tO\navailable\tO\nregarding\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tO\nof\tO\nchemotherapy\tO\nin\tO\nthis\tO\ngroup\tO\nof\tO\npatients\tO\n.\tT-1\n\nBACKGROUND\tO\n:\tO\nAlthough\tO\nthe\tO\nprevalence\tT-0\nof\tT-0\nnonsmall\tO\ncell\tO\nlung\tO\ncarcinoma\tO\n(\tO\nNSCLC\tB-Disease\n)\tO\nis\tO\nhigh\tO\namong\tO\nelderly\tO\npatients\tO\n,\tO\nfew\tO\ndata\tO\nare\tO\navailable\tO\nregarding\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tO\nof\tO\nchemotherapy\tO\nin\tO\nthis\tO\ngroup\tO\nof\tO\npatients\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAlthough\tO\nthe\tO\nprevalence\tO\nof\tO\nnonsmall\tO\ncell\tO\nlung\tO\ncarcinoma\tO\n(\tO\nNSCLC\tO\n)\tO\nis\tO\nhigh\tO\namong\tO\nelderly\tO\npatients\tO\n,\tO\nfew\tO\ndata\tO\nare\tO\navailable\tO\nregarding\tO\nthe\tO\nefficacy\tT-0\nand\tO\ntoxicity\tB-Disease\nof\tO\nchemotherapy\tO\nin\tO\nthis\tO\ngroup\tO\nof\tO\npatients\tO\n.\tO\n\nRecent\tO\nreports\tO\nindicate\tO\nthat\tO\nsingle\tO\nagent\tO\ntherapy\tT-0\nwith\tT-0\nvinorelbine\tB-Chemical\n(\tO\nVNB\tO\n)\tO\nor\tO\ngemcitabine\tO\n(\tO\nGEM\tO\n)\tO\nmay\tO\nobtain\tO\na\tO\nresponse\tO\nrate\tO\nof\tO\n20\tO\n-\tO\n30\tO\n%\tO\nin\tO\nelderly\tO\npatients\tO\n,\tO\nwith\tO\nacceptable\tO\ntoxicity\tO\nand\tO\nimprovement\tO\nin\tO\nsymptoms\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nRecent\tO\nreports\tO\nindicate\tO\nthat\tO\nsingle\tO\nagent\tO\ntherapy\tT-1\nwith\tT-1\nvinorelbine\tT-0\n(\tT-0\nVNB\tT-0\n)\tT-0\nor\tT-0\ngemcitabine\tB-Chemical\n(\tO\nGEM\tO\n)\tO\nmay\tT-2\nobtain\tT-2\na\tO\nresponse\tO\nrate\tO\nof\tO\n20\tO\n-\tO\n30\tO\n%\tO\nin\tO\nelderly\tO\npatients\tO\n,\tO\nwith\tO\nacceptable\tO\ntoxicity\tO\nand\tO\nimprovement\tO\nin\tO\nsymptoms\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nRecent\tO\nreports\tO\nindicate\tO\nthat\tO\nsingle\tO\nagent\tO\ntherapy\tT-0\nwith\tT-0\nvinorelbine\tO\n(\tO\nVNB\tO\n)\tO\nor\tO\ngemcitabine\tO\n(\tO\nGEM\tB-Chemical\n)\tO\nmay\tT-1\nobtain\tT-1\na\tO\nresponse\tO\nrate\tO\nof\tO\n20\tO\n-\tO\n30\tO\n%\tO\nin\tO\nelderly\tO\npatients\tO\n,\tO\nwith\tO\nacceptable\tO\ntoxicity\tO\nand\tO\nimprovement\tO\nin\tO\nsymptoms\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nRecent\tO\nreports\tO\nindicate\tO\nthat\tO\nsingle\tO\nagent\tO\ntherapy\tO\nwith\tO\nvinorelbine\tO\n(\tO\nVNB\tO\n)\tO\nor\tO\ngemcitabine\tO\n(\tO\nGEM\tO\n)\tO\nmay\tO\nobtain\tO\na\tO\nresponse\tT-0\nrate\tT-0\nof\tO\n20\tO\n-\tO\n30\tO\n%\tO\nin\tO\nelderly\tO\npatients\tO\n,\tO\nwith\tO\nacceptable\tO\ntoxicity\tB-Disease\nand\tT-2\nimprovement\tT-2\nin\tO\nsymptoms\tO\nand\tO\nquality\tO\nof\tO\nlife\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\nthe\tO\nefficacy\tO\nand\tT-0\ntoxicity\tB-Disease\nof\tT-1\nthe\tT-1\ncombination\tT-1\nof\tO\nGEM\tO\nand\tO\nVNB\tO\nin\tO\nelderly\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tO\nor\tO\nthose\tO\nwith\tO\nsome\tO\ncontraindication\tO\nto\tO\nreceiving\tO\ncisplatin\tO\nwere\tO\nassessed\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tT-0\nof\tO\nthe\tO\ncombination\tT-1\nof\tT-1\nGEM\tB-Chemical\nand\tT-2\nVNB\tT-2\nin\tO\nelderly\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tO\nor\tO\nthose\tO\nwith\tO\nsome\tO\ncontraindication\tO\nto\tO\nreceiving\tO\ncisplatin\tO\nwere\tO\nassessed\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\nthe\tT-0\nefficacy\tT-0\nand\tT-0\ntoxicity\tT-0\nof\tT-0\nthe\tO\ncombination\tO\nof\tO\nGEM\tO\nand\tO\nVNB\tB-Chemical\nin\tT-1\nelderly\tO\npatients\tT-2\nwith\tO\nadvanced\tO\nNSCLC\tO\nor\tO\nthose\tO\nwith\tO\nsome\tO\ncontraindication\tO\nto\tO\nreceiving\tO\ncisplatin\tO\nwere\tO\nassessed\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tO\nof\tO\nthe\tO\ncombination\tO\nof\tO\nGEM\tO\nand\tO\nVNB\tO\nin\tO\nelderly\tO\npatients\tT-0\nwith\tT-0\nadvanced\tT-1\nNSCLC\tB-Disease\nor\tO\nthose\tO\nwith\tO\nsome\tO\ncontraindication\tO\nto\tO\nreceiving\tO\ncisplatin\tO\nwere\tO\nassessed\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\nthe\tO\nefficacy\tO\nand\tO\ntoxicity\tO\nof\tO\nthe\tO\ncombination\tO\nof\tO\nGEM\tO\nand\tO\nVNB\tO\nin\tO\nelderly\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tO\nor\tO\nthose\tO\nwith\tO\nsome\tO\ncontraindication\tO\nto\tT-1\nreceiving\tT-1\ncisplatin\tB-Chemical\nwere\tO\nassessed\tO\n.\tO\n\nMETHODS\tO\n:\tO\nForty\tO\n-\tO\nnine\tO\npatients\tO\nwith\tT-1\nadvanced\tT-1\nNSCLC\tB-Disease\nwere\tT-2\nincluded\tT-2\n,\tO\n38\tO\nof\tO\nwhom\tO\nwere\tO\nage\tO\n>\tO\n/\tO\n=\tO\n70\tO\nyears\tO\nand\tO\n11\tO\nwere\tO\nage\tO\n<\tO\n70\tO\nyears\tO\nbut\tO\nwho\tO\nhad\tO\nsome\tO\ncontraindication\tO\nto\tO\nreceiving\tO\ncisplatin\tO\n.\tO\n\nMETHODS\tO\n:\tO\nForty\tO\n-\tO\nnine\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tO\nwere\tO\nincluded\tO\n,\tO\n38\tO\nof\tO\nwhom\tO\nwere\tO\nage\tO\n>\tO\n/\tO\n=\tO\n70\tO\nyears\tO\nand\tO\n11\tO\nwere\tO\nage\tO\n<\tO\n70\tO\nyears\tO\nbut\tO\nwho\tO\nhad\tO\nsome\tO\ncontraindication\tT-0\nto\tO\nreceiving\tT-1\ncisplatin\tB-Chemical\n.\tO\n\nTreatment\tO\nwas\tO\ncomprised\tT-0\nof\tO\nVNB\tB-Chemical\n,\tO\n25\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n,\tO\nplus\tO\nGEM\tO\n,\tO\n1000\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n,\tO\nboth\tO\non\tO\nDays\tO\n1\tO\n,\tO\n8\tO\n,\tO\nand\tO\n15\tO\nevery\tO\n28\tO\ndays\tO\n.\tO\n\nTreatment\tO\nwas\tT-1\ncomprised\tT-1\nof\tT-1\nVNB\tO\n,\tO\n25\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n,\tO\nplus\tO\nGEM\tB-Chemical\n,\tO\n1000\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n,\tO\nboth\tO\non\tO\nDays\tO\n1\tO\n,\tO\n8\tO\n,\tO\nand\tO\n15\tO\nevery\tO\n28\tO\ndays\tO\n.\tO\n\nToxicity\tB-Disease\nwas\tT-0\nmild\tT-0\n.\tO\n\nSix\tO\npatients\tO\n(\tO\n12\tO\n%\tO\n)\tO\nhad\tO\nWorld\tO\nHealth\tO\nOrganization\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tO\n,\tO\n2\tO\npatients\tO\n(\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nGrade\tT-0\n3\tT-0\n-\tT-0\n4\tT-0\nthrombocytopenia\tB-Disease\n,\tO\nand\tO\n2\tO\npatients\tO\n(\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nGrade\tO\n3\tO\nneurotoxicity\tO\n.\tO\n\nSix\tO\npatients\tO\n(\tO\n12\tO\n%\tO\n)\tO\nhad\tO\nWorld\tO\nHealth\tO\nOrganization\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tO\n,\tO\n2\tO\npatients\tO\n(\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nthrombocytopenia\tO\n,\tO\nand\tO\n2\tO\npatients\tO\n(\tO\n4\tO\n%\tO\n)\tO\nhad\tO\nGrade\tT-0\n3\tT-0\nneurotoxicity\tB-Disease\n.\tO\n\nThree\tO\npatients\tO\nwith\tO\nsevere\tT-1\nneutropenia\tB-Disease\n(\tT-2\n6\tT-2\n%\tT-2\n)\tT-2\ndied\tT-2\nof\tT-0\nsepsis\tT-0\n.\tT-0\n\nThree\tO\npatients\tO\nwith\tO\nsevere\tT-0\nneutropenia\tO\n(\tO\n6\tO\n%\tO\n)\tO\ndied\tT-2\nof\tT-2\nsepsis\tB-Disease\n.\tO\n\nThe\tO\nmedian\tO\nage\tO\nof\tO\nthose\tO\npatients\tO\ndeveloping\tO\nGrade\tT-0\n3\tT-0\n-\tT-0\n4\tT-0\nneutropenia\tB-Disease\nwas\tT-1\nsignificantly\tT-1\nhigher\tO\nthan\tO\nthat\tO\nof\tO\nthe\tO\nremaining\tO\npatients\tO\n(\tO\n75\tO\nyears\tO\nvs\tO\n.\tO\n72\tO\nyears\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n047\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tT-0\nof\tT-0\nGEM\tB-Chemical\nand\tT-1\nVNB\tO\nis\tO\nmoderately\tT-2\nactive\tT-2\nand\tO\nwell\tO\ntolerated\tO\nexcept\tO\nin\tO\npatients\tO\nage\tO\n>\tO\n/\tO\n=\tO\n75\tO\nyears\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tT-0\nof\tT-0\nGEM\tO\nand\tT-2\nVNB\tB-Chemical\nis\tO\nmoderately\tO\nactive\tO\nand\tO\nwell\tT-1\ntolerated\tT-1\nexcept\tO\nin\tO\npatients\tO\nage\tO\n>\tO\n/\tO\n=\tO\n75\tO\nyears\tO\n.\tO\n\nThis\tO\nage\tO\ngroup\tO\nhad\tO\nan\tO\nincreased\tO\nrisk\tT-0\nof\tT-0\nmyelosuppression\tB-Disease\n.\tO\n\nNew\tO\nchemotherapy\tO\ncombinations\tO\nwith\tO\nhigher\tO\nactivity\tO\nand\tO\nlower\tO\ntoxicity\tB-Disease\nare\tO\nneeded\tT-0\nfor\tT-0\nelderly\tO\npatients\tO\nwith\tO\nadvanced\tO\nNSCLC\tO\n.\tO\n\nNew\tO\nchemotherapy\tO\ncombinations\tT-0\nwith\tO\nhigher\tO\nactivity\tO\nand\tO\nlower\tT-2\ntoxicity\tT-2\nare\tO\nneeded\tO\nfor\tO\nelderly\tO\npatients\tT-1\nwith\tT-1\nadvanced\tT-1\nNSCLC\tB-Disease\n.\tO\n\nA\tO\nselective\tT-1\ndopamine\tB-Chemical\nD4\tT-0\nreceptor\tT-0\nantagonist\tO\n,\tO\nNRA0160\tO\n:\tO\na\tO\npreclinical\tO\nneuropharmacological\tO\nprofile\tO\n.\tO\n\nA\tO\nselective\tO\ndopamine\tO\nD4\tO\nreceptor\tO\nantagonist\tO\n,\tO\nNRA0160\tB-Chemical\n:\tT-0\na\tT-0\npreclinical\tT-0\nneuropharmacological\tO\nprofile\tO\n.\tO\n\nNRA0160\tT-0\n,\tO\n5\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\nfluorobenzylidene\tI-Chemical\n)\tI-Chemical\npiperidin\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\nyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nfluorophenyl\tI-Chemical\n)\tI-Chemical\nthiazole\tI-Chemical\n-\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\ncarboxamide\tI-Chemical\n,\tO\nhas\tO\na\tO\nhigh\tO\naffinity\tO\nfor\tO\nhuman\tO\ncloned\tO\ndopamine\tO\nD4\tO\n.\tO\n2\tO\n,\tO\nD4\tO\n.\tO\n4\tO\nand\tO\nD4\tO\n.\tO\n7\tO\nreceptors\tO\n,\tO\nwith\tO\nKi\tO\nvalues\tO\nof\tO\n0\tO\n.\tO\n5\tO\n,\tO\n0\tO\n.\tO\n9\tO\nand\tO\n2\tO\n.\tO\n7\tO\nnM\tO\n,\tO\nrespectively\tO\n.\tO\n\nNRA0160\tB-Chemical\nis\tO\nover\tO\n20\tO\n,\tO\n000fold\tO\nmore\tT-0\npotent\tT-0\nat\tO\nthe\tO\ndopamine\tO\nD4\tO\n.\tO\n2\tO\nreceptor\tO\ncompared\tO\nwith\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tO\nD2L\tO\nreceptor\tO\n.\tO\n\nNRA0160\tO\nis\tO\nover\tO\n20\tO\n,\tO\n000fold\tO\nmore\tT-0\npotent\tT-0\nat\tT-0\nthe\tT-0\ndopamine\tB-Chemical\nD4\tT-1\n.\tT-1\n2\tT-1\nreceptor\tT-1\ncompared\tO\nwith\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tO\nD2L\tO\nreceptor\tO\n.\tO\n\nNRA0160\tO\nis\tO\nover\tO\n20\tO\n,\tO\n000fold\tO\nmore\tO\npotent\tO\nat\tO\nthe\tO\ndopamine\tO\nD4\tO\n.\tO\n2\tO\nreceptor\tO\ncompared\tT-0\nwith\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tB-Chemical\nD2L\tO\nreceptor\tO\n.\tO\n\nNRA0160\tB-Chemical\nhas\tO\nnegligible\tT-0\naffinity\tO\nfor\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tO\nD3\tO\nreceptor\tO\n(\tO\nKi\tO\n=\tO\n39\tO\nnM\tO\n)\tO\n,\tO\nrat\tO\nserotonin\tO\n(\tO\n5\tO\n-\tO\nHT\tO\n)\tO\n2A\tO\nreceptors\tO\n(\tO\nKi\tO\n=\tO\n180\tO\nnM\tO\n)\tO\nand\tO\nrat\tO\nalpha1\tO\nadrenoceptor\tO\n(\tO\nKi\tO\n=\tO\n237\tO\nnM\tO\n)\tO\n.\tO\n\nNRA0160\tO\nhas\tO\nnegligible\tT-1\naffinity\tT-1\nfor\tT-1\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tB-Chemical\nD3\tT-0\nreceptor\tT-0\n(\tO\nKi\tO\n=\tO\n39\tO\nnM\tO\n)\tO\n,\tO\nrat\tO\nserotonin\tO\n(\tO\n5\tO\n-\tO\nHT\tO\n)\tO\n2A\tO\nreceptors\tO\n(\tO\nKi\tO\n=\tO\n180\tO\nnM\tO\n)\tO\nand\tO\nrat\tO\nalpha1\tO\nadrenoceptor\tO\n(\tO\nKi\tO\n=\tO\n237\tO\nnM\tO\n)\tO\n.\tO\n\nNRA0160\tO\nhas\tO\nnegligible\tT-0\naffinity\tO\nfor\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tO\nD3\tO\nreceptor\tO\n(\tO\nKi\tO\n=\tO\n39\tO\nnM\tO\n)\tO\n,\tO\nrat\tO\nserotonin\tB-Chemical\n(\tO\n5\tO\n-\tO\nHT\tO\n)\tO\n2A\tO\nreceptors\tO\n(\tO\nKi\tO\n=\tO\n180\tO\nnM\tO\n)\tO\nand\tO\nrat\tO\nalpha1\tO\nadrenoceptor\tO\n(\tO\nKi\tO\n=\tO\n237\tO\nnM\tO\n)\tO\n.\tO\n\nNRA0160\tO\nhas\tO\nnegligible\tT-0\naffinity\tT-0\nfor\tO\nthe\tO\nhuman\tO\ncloned\tO\ndopamine\tO\nD3\tO\nreceptor\tO\n(\tO\nKi\tO\n=\tO\n39\tO\nnM\tO\n)\tO\n,\tO\nrat\tO\nserotonin\tO\n(\tO\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n)\tO\n2A\tO\nreceptors\tO\n(\tO\nKi\tO\n=\tO\n180\tO\nnM\tO\n)\tO\nand\tO\nrat\tO\nalpha1\tO\nadrenoceptor\tO\n(\tO\nKi\tO\n=\tO\n237\tO\nnM\tO\n)\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tT-0\nclozapine\tO\nantagonized\tT-1\nlocomotor\tT-1\nhyperactivity\tT-1\ninduced\tO\nby\tO\nmethamphetamine\tO\n(\tO\nMAP\tO\n)\tO\nin\tO\nmice\tO\n.\tO\n\nNRA0160\tT-0\nand\tT-0\nclozapine\tB-Chemical\nantagonized\tO\nlocomotor\tO\nhyperactivity\tO\ninduced\tT-1\nby\tT-1\nmethamphetamine\tO\n(\tO\nMAP\tO\n)\tO\nin\tO\nmice\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tO\nantagonized\tT-0\nlocomotor\tT-0\nhyperactivity\tB-Disease\ninduced\tT-1\nby\tT-1\nmethamphetamine\tO\n(\tO\nMAP\tO\n)\tO\nin\tO\nmice\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tO\nantagonized\tT-0\nlocomotor\tO\nhyperactivity\tO\ninduced\tT-1\nby\tT-1\nmethamphetamine\tB-Chemical\n(\tO\nMAP\tO\n)\tO\nin\tO\nmice\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tO\nantagonized\tO\nlocomotor\tO\nhyperactivity\tO\ninduced\tT-0\nby\tT-0\nmethamphetamine\tO\n(\tO\nMAP\tB-Chemical\n)\tO\nin\tO\nmice\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tO\nantagonized\tO\nMAP\tO\n-\tO\ninduced\tT-2\nstereotyped\tO\nbehavior\tO\nin\tO\nmice\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tO\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninhibition\tT-1\n,\tO\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tT-0\nand\tT-0\nclozapine\tB-Chemical\nantagonized\tO\nMAP\tO\n-\tO\ninduced\tT-1\nstereotyped\tO\nbehavior\tO\nin\tO\nmice\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tT-2\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninhibition\tO\n,\tO\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tT-0\nantagonized\tT-2\nMAP\tB-Chemical\n-\tT-1\ninduced\tT-3\nstereotyped\tO\nbehavior\tO\nin\tO\nmice\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tO\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninhibition\tO\n,\tO\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tO\nsignificantly\tO\ninduced\tT-1\ncatalepsy\tO\nin\tO\nrats\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tT-2\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninduction\tT-3\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tB-Chemical\nsignificantly\tO\ninduced\tT-0\ncatalepsy\tO\nin\tO\nrats\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tO\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninduction\tO\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tO\nsignificantly\tO\ninduced\tT-1\ncatalepsy\tB-Disease\nin\tO\nrats\tO\n,\tO\nalthough\tO\ntheir\tO\neffects\tO\ndid\tO\nnot\tO\nexceed\tO\n50\tO\n%\tO\ninduction\tT-0\neven\tO\nat\tO\nthe\tO\nhighest\tO\ndose\tO\ngiven\tO\n.\tO\n\nNRA0160\tB-Chemical\nand\tT-0\nclozapine\tT-0\nsignificantly\tO\nreversed\tO\nthe\tO\ndisruption\tO\nof\tO\nprepulse\tO\ninhibition\tO\n(\tO\nPPI\tO\n)\tO\nin\tO\nrats\tO\nproduced\tO\nby\tO\napomorphine\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tB-Chemical\nsignificantly\tO\nreversed\tT-2\nthe\tO\ndisruption\tO\nof\tO\nprepulse\tO\ninhibition\tO\n(\tO\nPPI\tO\n)\tO\nin\tO\nrats\tO\nproduced\tT-1\nby\tO\napomorphine\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tO\nsignificantly\tT-3\nreversed\tT-3\nthe\tO\ndisruption\tO\nof\tO\nprepulse\tO\ninhibition\tO\n(\tO\nPPI\tO\n)\tO\nin\tO\nrats\tO\nproduced\tT-2\nby\tT-2\napomorphine\tB-Chemical\n.\tO\n\nNRA0160\tB-Chemical\nand\tO\nclozapine\tO\nsignificantly\tT-0\nshortened\tT-0\nthe\tO\nphencyclidine\tO\n(\tO\nPCP\tO\n)\tO\n-\tO\ninduced\tT-1\nprolonged\tO\nswimming\tO\nlatency\tO\nin\tO\nrats\tO\nin\tO\na\tO\nwater\tO\nmaze\tO\ntask\tO\n.\tO\n\nNRA0160\tO\nand\tT-0\nclozapine\tB-Chemical\nsignificantly\tO\nshortened\tO\nthe\tO\nphencyclidine\tO\n(\tO\nPCP\tO\n)\tO\n-\tO\ninduced\tO\nprolonged\tO\nswimming\tO\nlatency\tO\nin\tO\nrats\tO\nin\tO\na\tO\nwater\tO\nmaze\tO\ntask\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tO\nsignificantly\tO\nshortened\tT-1\nthe\tT-1\nphencyclidine\tB-Chemical\n(\tO\nPCP\tO\n)\tO\n-\tO\ninduced\tT-0\nprolonged\tO\nswimming\tO\nlatency\tO\nin\tO\nrats\tO\nin\tO\na\tO\nwater\tO\nmaze\tO\ntask\tO\n.\tO\n\nNRA0160\tO\nand\tO\nclozapine\tO\nsignificantly\tO\nshortened\tO\nthe\tO\nphencyclidine\tO\n(\tO\nPCP\tB-Chemical\n)\tO\n-\tT-1\ninduced\tT-1\nprolonged\tO\nswimming\tO\nlatency\tO\nin\tO\nrats\tO\nin\tO\na\tO\nwater\tO\nmaze\tO\ntask\tO\n.\tO\n\nThese\tO\nfindings\tT-0\nsuggest\tT-1\nthat\tT-1\nNRA0160\tB-Chemical\nmay\tT-2\nhave\tT-2\nunique\tO\nantipsychotic\tO\nactivities\tO\nwithout\tO\nthe\tO\nliability\tO\nof\tO\nmotor\tO\nside\tO\neffects\tO\ntypical\tO\nof\tO\nclassical\tO\nantipsychotics\tO\n.\tO\n\nWarfarin\tB-Chemical\n-\tO\ninduced\tT-0\nartery\tO\ncalcification\tO\nis\tO\naccelerated\tT-1\nby\tT-1\ngrowth\tO\nand\tO\nvitamin\tO\nD\tO\n.\tT-2\n\nWarfarin\tO\n-\tO\ninduced\tT-1\nartery\tB-Disease\ncalcification\tI-Disease\nis\tO\naccelerated\tT-2\nby\tT-2\ngrowth\tO\nand\tO\nvitamin\tO\nD\tO\n.\tO\n\nWarfarin\tO\n-\tO\ninduced\tO\nartery\tO\ncalcification\tO\nis\tT-1\naccelerated\tT-1\nby\tT-1\ngrowth\tO\nand\tO\nvitamin\tB-Chemical\nD\tI-Chemical\n.\tO\n\nThe\tO\npresent\tO\nstudies\tO\ndemonstrate\tT-1\nthat\tO\ngrowth\tT-2\nand\tO\nvitamin\tB-Chemical\nD\tI-Chemical\ntreatment\tT-0\nenhance\tT-3\nthe\tT-3\nextent\tT-3\nof\tO\nartery\tO\ncalcification\tO\nin\tO\nrats\tO\ngiven\tO\nsufficient\tO\ndoses\tO\nof\tO\nWarfarin\tO\nto\tO\ninhibit\tO\ngamma\tO\n-\tO\ncarboxylation\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\n,\tO\na\tO\ncalcification\tO\ninhibitor\tO\nknown\tO\nto\tO\nbe\tO\nexpressed\tO\nby\tO\nsmooth\tO\nmuscle\tO\ncells\tO\nand\tO\nmacrophages\tO\nin\tO\nthe\tO\nartery\tO\nwall\tO\n.\tO\n\nThe\tO\npresent\tO\nstudies\tO\ndemonstrate\tO\nthat\tO\ngrowth\tO\nand\tO\nvitamin\tO\nD\tO\ntreatment\tO\nenhance\tT-0\nthe\tO\nextent\tO\nof\tO\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nrats\tO\ngiven\tO\nsufficient\tO\ndoses\tO\nof\tO\nWarfarin\tO\nto\tO\ninhibit\tO\ngamma\tO\n-\tO\ncarboxylation\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\n,\tO\na\tO\ncalcification\tO\ninhibitor\tO\nknown\tO\nto\tO\nbe\tO\nexpressed\tO\nby\tO\nsmooth\tO\nmuscle\tO\ncells\tO\nand\tO\nmacrophages\tO\nin\tO\nthe\tO\nartery\tO\nwall\tO\n.\tO\n\nThe\tO\npresent\tO\nstudies\tO\ndemonstrate\tO\nthat\tO\ngrowth\tO\nand\tO\nvitamin\tO\nD\tO\ntreatment\tO\nenhance\tO\nthe\tO\nextent\tO\nof\tO\nartery\tO\ncalcification\tO\nin\tO\nrats\tO\ngiven\tO\nsufficient\tO\ndoses\tT-1\nof\tT-1\nWarfarin\tB-Chemical\nto\tO\ninhibit\tT-0\ngamma\tO\n-\tO\ncarboxylation\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\n,\tO\na\tO\ncalcification\tO\ninhibitor\tO\nknown\tO\nto\tO\nbe\tO\nexpressed\tO\nby\tO\nsmooth\tO\nmuscle\tO\ncells\tO\nand\tO\nmacrophages\tO\nin\tO\nthe\tO\nartery\tO\nwall\tO\n.\tO\n\nThe\tO\npresent\tO\nstudies\tO\ndemonstrate\tO\nthat\tO\ngrowth\tO\nand\tO\nvitamin\tO\nD\tO\ntreatment\tO\nenhance\tO\nthe\tO\nextent\tO\nof\tO\nartery\tO\ncalcification\tO\nin\tO\nrats\tO\ngiven\tO\nsufficient\tO\ndoses\tO\nof\tO\nWarfarin\tO\nto\tO\ninhibit\tO\ngamma\tO\n-\tO\ncarboxylation\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\n,\tO\na\tO\ncalcification\tB-Disease\ninhibitor\tT-1\nknown\tT-1\nto\tO\nbe\tO\nexpressed\tO\nby\tO\nsmooth\tO\nmuscle\tO\ncells\tO\nand\tO\nmacrophages\tO\nin\tO\nthe\tO\nartery\tO\nwall\tO\n.\tO\n\nThe\tO\nfirst\tO\nseries\tO\nof\tO\nexperiments\tO\nexamined\tO\nthe\tO\ninfluence\tT-1\nof\tT-1\nage\tO\nand\tO\ngrowth\tO\nstatus\tT-0\non\tT-0\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nWarfarin\tO\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nThe\tO\nfirst\tO\nseries\tO\nof\tO\nexperiments\tO\nexamined\tO\nthe\tT-0\ninfluence\tT-0\nof\tO\nage\tO\nand\tO\ngrowth\tO\nstatus\tO\non\tO\nartery\tO\ncalcification\tO\nin\tO\nWarfarin\tB-Chemical\n-\tO\ntreated\tO\nrats\tO\n.\tO\n\nTreatment\tT-0\nfor\tO\n2\tO\nweeks\tO\nwith\tT-1\nWarfarin\tB-Chemical\ncaused\tT-2\nmassive\tO\nfocal\tO\ncalcification\tO\nof\tO\nthe\tO\nartery\tO\nmedia\tO\nin\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nless\tO\nextensive\tO\nfocal\tO\ncalcification\tO\nin\tO\n42\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\n.\tO\n\nTreatment\tO\nfor\tO\n2\tO\nweeks\tO\nwith\tO\nWarfarin\tO\ncaused\tT-1\nmassive\tT-1\nfocal\tT-1\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\nin\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nless\tO\nextensive\tO\nfocal\tO\ncalcification\tO\nin\tO\n42\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\n.\tO\n\nTreatment\tT-1\nfor\tT-1\n2\tT-1\nweeks\tT-1\nwith\tT-1\nWarfarin\tT-1\ncaused\tT-1\nmassive\tO\nfocal\tO\ncalcification\tO\nof\tO\nthe\tO\nartery\tO\nmedia\tO\nin\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nless\tT-0\nextensive\tT-0\nfocal\tO\ncalcification\tB-Disease\nin\tO\n42\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nno\tO\nartery\tB-Disease\ncalcification\tI-Disease\ncould\tT-0\nbe\tT-0\ndetected\tT-0\nin\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nadult\tO\nrats\tO\neven\tO\nafter\tO\n4\tO\nweeks\tO\nof\tO\nWarfarin\tO\ntreatment\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nno\tO\nartery\tO\ncalcification\tO\ncould\tO\nbe\tO\ndetected\tO\nin\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nadult\tO\nrats\tO\neven\tO\nafter\tO\n4\tO\nweeks\tO\nof\tT-2\nWarfarin\tB-Chemical\ntreatment\tT-1\n.\tT-1\n\nTo\tO\ndirectly\tO\nexamine\tO\nthe\tO\nimportance\tO\nof\tO\ngrowth\tO\nto\tO\nWarfarin\tB-Chemical\n-\tO\ninduced\tT-0\nartery\tO\ncalcification\tO\nin\tO\nanimals\tO\nof\tO\nthe\tO\nsame\tO\nage\tO\n,\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\nwere\tO\nfed\tO\nfor\tO\n2\tO\nweeks\tO\neither\tO\nan\tO\nad\tO\nlibitum\tO\ndiet\tO\nor\tO\na\tO\n6\tO\n-\tO\ng\tO\n/\tO\nd\tO\nrestricted\tO\ndiet\tO\nthat\tO\nmaintains\tO\nweight\tO\nbut\tO\nprevents\tO\ngrowth\tO\n.\tO\n\nTo\tO\ndirectly\tO\nexamine\tO\nthe\tO\nimportance\tO\nof\tO\ngrowth\tO\nto\tO\nWarfarin\tO\n-\tO\ninduced\tT-0\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nanimals\tO\nof\tO\nthe\tO\nsame\tO\nage\tO\n,\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\nwere\tO\nfed\tO\nfor\tO\n2\tO\nweeks\tO\neither\tO\nan\tO\nad\tO\nlibitum\tO\ndiet\tO\nor\tO\na\tO\n6\tO\n-\tO\ng\tO\n/\tO\nd\tO\nrestricted\tO\ndiet\tO\nthat\tO\nmaintains\tO\nweight\tO\nbut\tO\nprevents\tO\ngrowth\tO\n.\tO\n\nConcurrent\tO\ntreatment\tO\nof\tO\nboth\tO\ndietary\tO\ngroups\tO\nwith\tO\nWarfarin\tB-Chemical\nproduced\tT-0\nmassive\tO\nfocal\tO\ncalcification\tO\nof\tO\nthe\tO\nartery\tO\nmedia\tO\nin\tO\nthe\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\nbut\tO\nno\tO\ndetectable\tO\nartery\tO\ncalcification\tO\nin\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\ngroup\tO\n.\tO\n\nConcurrent\tO\ntreatment\tO\nof\tO\nboth\tO\ndietary\tO\ngroups\tO\nwith\tO\nWarfarin\tO\nproduced\tT-0\nmassive\tT-0\nfocal\tT-0\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\nin\tO\nthe\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\nbut\tO\nno\tO\ndetectable\tO\nartery\tO\ncalcification\tO\nin\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\ngroup\tO\n.\tO\n\nConcurrent\tO\ntreatment\tO\nof\tO\nboth\tO\ndietary\tO\ngroups\tO\nwith\tO\nWarfarin\tO\nproduced\tO\nmassive\tO\nfocal\tO\ncalcification\tO\nof\tO\nthe\tO\nartery\tO\nmedia\tO\nin\tO\nthe\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\nbut\tO\nno\tT-1\ndetectable\tT-1\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\ngroup\tO\n.\tO\n\nAlthough\tO\nthe\tO\nexplanation\tO\nfor\tO\nthe\tT-0\nassociation\tT-0\nbetween\tT-0\nartery\tB-Disease\ncalcification\tI-Disease\nand\tO\ngrowth\tO\nstatus\tO\ncannot\tO\nbe\tO\ndetermined\tO\nfrom\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nrelationship\tO\nbetween\tO\nhigher\tO\nserum\tO\nphosphate\tO\nand\tO\nsusceptibility\tO\nto\tO\nartery\tO\ncalcification\tO\n,\tO\nwith\tO\n30\tO\n%\tO\nhigher\tO\nlevels\tO\nof\tO\nserum\tO\nphosphate\tO\nin\tO\nyoung\tO\n,\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\ncompared\tO\nwith\tO\neither\tO\nof\tO\nthe\tO\ngroups\tO\nthat\tO\nwas\tO\nresistant\tO\nto\tO\nWarfarin\tO\n-\tO\ninduced\tO\nartery\tO\ncalcification\tO\n,\tO\nie\tO\n,\tO\nthe\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\nyoung\tO\nrats\tO\n.\tO\n\nAlthough\tO\nthe\tO\nexplanation\tO\nfor\tO\nthe\tO\nassociation\tO\nbetween\tO\nartery\tO\ncalcification\tO\nand\tO\ngrowth\tO\nstatus\tO\ncannot\tT-1\nbe\tT-1\ndetermined\tT-1\nfrom\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nrelationship\tT-0\nbetween\tT-0\nhigher\tO\nserum\tO\nphosphate\tB-Chemical\nand\tO\nsusceptibility\tO\nto\tO\nartery\tO\ncalcification\tO\n,\tO\nwith\tO\n30\tO\n%\tO\nhigher\tO\nlevels\tO\nof\tO\nserum\tO\nphosphate\tO\nin\tO\nyoung\tO\n,\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\ncompared\tO\nwith\tO\neither\tO\nof\tO\nthe\tO\ngroups\tO\nthat\tO\nwas\tO\nresistant\tT-2\nto\tT-2\nWarfarin\tO\n-\tO\ninduced\tO\nartery\tO\ncalcification\tO\n,\tO\nie\tO\n,\tO\nthe\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\nyoung\tO\nrats\tO\n.\tO\n\nAlthough\tO\nthe\tO\nexplanation\tO\nfor\tO\nthe\tO\nassociation\tT-1\nbetween\tT-1\nartery\tO\ncalcification\tO\nand\tO\ngrowth\tO\nstatus\tO\ncannot\tO\nbe\tO\ndetermined\tO\nfrom\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nrelationship\tT-0\nbetween\tT-0\nhigher\tO\nserum\tO\nphosphate\tO\nand\tO\nsusceptibility\tO\nto\tO\nartery\tB-Disease\ncalcification\tI-Disease\n,\tO\nwith\tO\n30\tO\n%\tO\nhigher\tO\nlevels\tO\nof\tO\nserum\tO\nphosphate\tO\nin\tO\nyoung\tO\n,\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\ncompared\tO\nwith\tO\neither\tO\nof\tO\nthe\tO\ngroups\tO\nthat\tO\nwas\tO\nresistant\tO\nto\tO\nWarfarin\tO\n-\tO\ninduced\tT-2\nartery\tO\ncalcification\tO\n,\tO\nie\tO\n,\tO\nthe\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tT-3\nyoung\tO\nrats\tO\n.\tO\n\nAlthough\tO\nthe\tO\nexplanation\tO\nfor\tO\nthe\tO\nassociation\tO\nbetween\tO\nartery\tO\ncalcification\tO\nand\tO\ngrowth\tO\nstatus\tO\ncannot\tO\nbe\tO\ndetermined\tO\nfrom\tO\nthe\tO\npresent\tO\nstudy\tT-0\n,\tO\nthere\tO\nwas\tO\na\tO\nrelationship\tO\nbetween\tO\nhigher\tO\nserum\tO\nphosphate\tO\nand\tO\nsusceptibility\tO\nto\tO\nartery\tO\ncalcification\tO\n,\tO\nwith\tO\n30\tO\n%\tO\nhigher\tO\nlevels\tO\nof\tT-2\nserum\tT-2\nphosphate\tB-Chemical\nin\tT-3\nyoung\tT-3\n,\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\ncompared\tO\nwith\tO\neither\tO\nof\tO\nthe\tO\ngroups\tO\nthat\tO\nwas\tO\nresistant\tT-1\nto\tT-1\nWarfarin\tO\n-\tO\ninduced\tO\nartery\tO\ncalcification\tO\n,\tO\nie\tO\n,\tO\nthe\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\nyoung\tO\nrats\tO\n.\tO\n\nAlthough\tO\nthe\tO\nexplanation\tO\nfor\tO\nthe\tO\nassociation\tO\nbetween\tO\nartery\tO\ncalcification\tO\nand\tO\ngrowth\tO\nstatus\tO\ncannot\tO\nbe\tO\ndetermined\tT-0\nfrom\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nrelationship\tO\nbetween\tO\nhigher\tO\nserum\tO\nphosphate\tO\nand\tO\nsusceptibility\tT-1\nto\tO\nartery\tO\ncalcification\tO\n,\tO\nwith\tO\n30\tO\n%\tO\nhigher\tO\nlevels\tO\nof\tO\nserum\tO\nphosphate\tO\nin\tO\nyoung\tO\n,\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\ncompared\tO\nwith\tO\neither\tO\nof\tO\nthe\tO\ngroups\tO\nthat\tO\nwas\tO\nresistant\tT-3\nto\tT-3\nWarfarin\tB-Chemical\n-\tO\ninduced\tT-2\nartery\tO\ncalcification\tO\n,\tO\nie\tO\n,\tO\nthe\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\nyoung\tO\nrats\tO\n.\tO\n\nAlthough\tO\nthe\tO\nexplanation\tO\nfor\tO\nthe\tO\nassociation\tO\nbetween\tO\nartery\tO\ncalcification\tO\nand\tO\ngrowth\tO\nstatus\tO\ncannot\tO\nbe\tO\ndetermined\tO\nfrom\tO\nthe\tO\npresent\tO\nstudy\tO\n,\tO\nthere\tO\nwas\tO\na\tO\nrelationship\tO\nbetween\tO\nhigher\tO\nserum\tO\nphosphate\tO\nand\tO\nsusceptibility\tO\nto\tO\nartery\tO\ncalcification\tO\n,\tO\nwith\tO\n30\tO\n%\tO\nhigher\tO\nlevels\tO\nof\tO\nserum\tO\nphosphate\tO\nin\tO\nyoung\tO\n,\tO\nad\tO\nlibitum\tO\n-\tO\nfed\tO\nrats\tO\ncompared\tO\nwith\tO\neither\tO\nof\tO\nthe\tO\ngroups\tO\nthat\tO\nwas\tO\nresistant\tO\nto\tO\nWarfarin\tO\n-\tO\ninduced\tT-0\nartery\tB-Disease\ncalcification\tI-Disease\n,\tO\nie\tO\n,\tO\nthe\tO\n10\tO\n-\tO\nmonth\tO\n-\tO\nold\tO\nrats\tO\nand\tO\nthe\tO\nrestricted\tO\n-\tO\ndiet\tO\n,\tO\ngrowth\tO\n-\tO\ninhibited\tO\nyoung\tO\nrats\tO\n.\tO\n\nThis\tO\nobservation\tO\nsuggests\tO\nthat\tO\nincreased\tO\nsusceptibility\tT-1\nto\tO\nWarfarin\tB-Chemical\n-\tO\ninduced\tT-2\nartery\tO\ncalcification\tO\ncould\tO\nbe\tO\nrelated\tT-3\nto\tT-3\nhigher\tO\nserum\tO\nphosphate\tO\nlevels\tO\n.\tO\n\nThis\tO\nobservation\tO\nsuggests\tO\nthat\tO\nincreased\tO\nsusceptibility\tO\nto\tO\nWarfarin\tO\n-\tO\ninduced\tT-0\nartery\tB-Disease\ncalcification\tI-Disease\ncould\tT-1\nbe\tT-1\nrelated\tO\nto\tO\nhigher\tO\nserum\tO\nphosphate\tO\nlevels\tO\n.\tO\n\nThis\tO\nobservation\tO\nsuggests\tO\nthat\tO\nincreased\tO\nsusceptibility\tT-0\nto\tO\nWarfarin\tO\n-\tO\ninduced\tT-1\nartery\tO\ncalcification\tO\ncould\tO\nbe\tO\nrelated\tO\nto\tO\nhigher\tO\nserum\tO\nphosphate\tB-Chemical\nlevels\tO\n.\tO\n\nThe\tO\nsecond\tO\nset\tO\nof\tO\nexperiments\tO\nexamined\tO\nthe\tO\npossible\tO\nsynergy\tT-2\nbetween\tT-2\nvitamin\tB-Chemical\nD\tI-Chemical\nand\tT-1\nWarfarin\tO\nin\tO\nartery\tO\ncalcification\tO\n.\tO\n\nThe\tO\nsecond\tO\nset\tO\nof\tO\nexperiments\tT-2\nexamined\tT-2\nthe\tO\npossible\tO\nsynergy\tT-4\nbetween\tT-4\nvitamin\tT-1\nD\tT-1\nand\tT-5\nWarfarin\tB-Chemical\nin\tO\nartery\tO\ncalcification\tO\n.\tO\n\nThe\tO\nsecond\tO\nset\tO\nof\tO\nexperiments\tO\nexamined\tO\nthe\tO\npossible\tO\nsynergy\tT-0\nbetween\tT-0\nvitamin\tO\nD\tO\nand\tO\nWarfarin\tO\nin\tO\nartery\tB-Disease\ncalcification\tI-Disease\n.\tO\n\nHigh\tT-1\ndoses\tT-1\nof\tT-1\nvitamin\tB-Chemical\nD\tI-Chemical\nare\tT-2\nknown\tT-2\nto\tT-2\ncause\tT-2\ncalcification\tO\nof\tO\nthe\tO\nartery\tO\nmedia\tO\nin\tO\nas\tO\nlittle\tO\nas\tO\n3\tO\nto\tO\n4\tO\ndays\tO\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\nvitamin\tO\nD\tO\nare\tT-2\nknown\tT-2\nto\tT-2\ncause\tT-2\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\nin\tO\nas\tO\nlittle\tO\nas\tO\n3\tO\nto\tO\n4\tO\ndays\tO\n.\tO\n\nHigh\tO\ndoses\tO\nof\tT-1\nthe\tT-1\nvitamin\tB-Chemical\nK\tI-Chemical\nantagonist\tO\nWarfarin\tO\nare\tT-0\nalso\tT-0\nknown\tT-0\nto\tT-0\ncause\tT-0\ncalcification\tO\nof\tO\nthe\tO\nartery\tO\nmedia\tO\n,\tO\nbut\tO\nat\tO\ntreatment\tO\ntimes\tO\nof\tO\n2\tO\nweeks\tO\nor\tO\nlonger\tO\nyet\tO\nnot\tO\nat\tO\n1\tO\nweek\tO\n.\tO\n\nHigh\tT-1\ndoses\tT-1\nof\tO\nthe\tO\nvitamin\tO\nK\tT-0\nantagonist\tT-0\nWarfarin\tB-Chemical\nare\tO\nalso\tO\nknown\tO\nto\tO\ncause\tT-2\ncalcification\tT-2\nof\tT-2\nthe\tO\nartery\tO\nmedia\tO\n,\tO\nbut\tO\nat\tO\ntreatment\tO\ntimes\tO\nof\tO\n2\tO\nweeks\tO\nor\tO\nlonger\tO\nyet\tO\nnot\tO\nat\tO\n1\tO\nweek\tO\n.\tO\n\nHigh\tO\ndoses\tO\nof\tO\nthe\tO\nvitamin\tO\nK\tO\nantagonist\tO\nWarfarin\tO\nare\tO\nalso\tO\nknown\tO\nto\tT-0\ncause\tT-0\ncalcification\tB-Disease\nof\tI-Disease\nthe\tI-Disease\nartery\tI-Disease\nmedia\tO\n,\tO\nbut\tO\nat\tO\ntreatment\tO\ntimes\tO\nof\tO\n2\tO\nweeks\tO\nor\tO\nlonger\tO\nyet\tO\nnot\tO\nat\tO\n1\tO\nweek\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\nsynergy\tO\nbetween\tO\nthese\tO\n2\tO\ntreatments\tO\nand\tO\nfound\tT-2\nthat\tT-2\nconcurrent\tO\nWarfarin\tB-Chemical\nadministration\tT-0\ndramatically\tT-3\nincreased\tT-3\nthe\tO\nextent\tO\nof\tO\ncalcification\tO\nin\tO\nthe\tO\nmedia\tO\nof\tO\nvitamin\tO\nD\tO\n-\tO\ntreated\tO\nrats\tO\nat\tO\n3\tO\nand\tO\n4\tO\ndays\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\nsynergy\tO\nbetween\tO\nthese\tO\n2\tO\ntreatments\tO\nand\tO\nfound\tO\nthat\tO\nconcurrent\tO\nWarfarin\tO\nadministration\tO\ndramatically\tO\nincreased\tT-2\nthe\tT-3\nextent\tT-3\nof\tT-3\ncalcification\tB-Disease\nin\tT-1\nthe\tT-1\nmedia\tO\nof\tO\nvitamin\tO\nD\tO\n-\tO\ntreated\tO\nrats\tO\nat\tO\n3\tO\nand\tO\n4\tO\ndays\tO\n.\tO\n\nIn\tO\nthe\tO\ncurrent\tO\nstudy\tO\n,\tO\nwe\tO\ninvestigated\tO\nthe\tO\nsynergy\tO\nbetween\tO\nthese\tO\n2\tO\ntreatments\tO\nand\tO\nfound\tO\nthat\tO\nconcurrent\tO\nWarfarin\tO\nadministration\tO\ndramatically\tT-1\nincreased\tT-1\nthe\tO\nextent\tO\nof\tO\ncalcification\tO\nin\tT-2\nthe\tT-2\nmedia\tT-2\nof\tO\nvitamin\tB-Chemical\nD\tI-Chemical\n-\tO\ntreated\tT-3\nrats\tO\nat\tO\n3\tO\nand\tO\n4\tO\ndays\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nclose\tO\nparallel\tO\nbetween\tO\nthe\tT-3\neffect\tT-3\nof\tT-3\nvitamin\tB-Chemical\nD\tI-Chemical\ndose\tT-4\non\tT-4\nartery\tT-4\ncalcification\tO\nand\tO\nthe\tO\neffect\tO\nof\tO\nvitamin\tO\nD\tO\ndose\tO\non\tO\nthe\tO\nelevation\tO\nof\tO\nserum\tO\ncalcium\tO\n,\tO\nwhich\tO\nsuggests\tO\nthat\tO\nvitamin\tO\nD\tO\nmay\tO\ninduce\tO\nartery\tO\ncalcification\tO\nthrough\tO\nits\tO\neffect\tO\non\tO\nserum\tO\ncalcium\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nclose\tO\nparallel\tO\nbetween\tO\nthe\tT-0\neffect\tT-0\nof\tT-0\nvitamin\tO\nD\tO\ndose\tT-2\non\tO\nartery\tB-Disease\ncalcification\tI-Disease\nand\tO\nthe\tO\neffect\tO\nof\tO\nvitamin\tO\nD\tO\ndose\tO\non\tO\nthe\tO\nelevation\tO\nof\tO\nserum\tO\ncalcium\tO\n,\tO\nwhich\tO\nsuggests\tT-1\nthat\tT-1\nvitamin\tO\nD\tO\nmay\tO\ninduce\tO\nartery\tO\ncalcification\tO\nthrough\tO\nits\tO\neffect\tO\non\tO\nserum\tO\ncalcium\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nclose\tO\nparallel\tO\nbetween\tO\nthe\tO\neffect\tO\nof\tO\nvitamin\tO\nD\tO\ndose\tO\non\tO\nartery\tO\ncalcification\tO\nand\tO\nthe\tO\neffect\tT-0\nof\tT-0\nvitamin\tB-Chemical\nD\tI-Chemical\ndose\tT-1\non\tO\nthe\tO\nelevation\tO\nof\tO\nserum\tO\ncalcium\tO\n,\tO\nwhich\tO\nsuggests\tO\nthat\tO\nvitamin\tO\nD\tO\nmay\tO\ninduce\tO\nartery\tO\ncalcification\tO\nthrough\tO\nits\tO\neffect\tO\non\tO\nserum\tO\ncalcium\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nclose\tO\nparallel\tO\nbetween\tO\nthe\tO\neffect\tT-0\nof\tO\nvitamin\tO\nD\tO\ndose\tO\non\tO\nartery\tO\ncalcification\tO\nand\tO\nthe\tO\neffect\tT-1\nof\tO\nvitamin\tO\nD\tO\ndose\tO\non\tO\nthe\tO\nelevation\tT-3\nof\tT-3\nserum\tO\ncalcium\tB-Chemical\n,\tO\nwhich\tO\nsuggests\tO\nthat\tO\nvitamin\tO\nD\tO\nmay\tO\ninduce\tT-4\nartery\tO\ncalcification\tO\nthrough\tO\nits\tO\neffect\tT-2\non\tO\nserum\tO\ncalcium\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nclose\tO\nparallel\tO\nbetween\tO\nthe\tO\neffect\tO\nof\tO\nvitamin\tO\nD\tO\ndose\tO\non\tO\nartery\tO\ncalcification\tO\nand\tO\nthe\tO\neffect\tO\nof\tO\nvitamin\tO\nD\tO\ndose\tO\non\tO\nthe\tO\nelevation\tO\nof\tO\nserum\tO\ncalcium\tO\n,\tO\nwhich\tO\nsuggests\tT-0\nthat\tT-0\nvitamin\tB-Chemical\nD\tI-Chemical\nmay\tT-1\ninduce\tT-1\nartery\tO\ncalcification\tO\nthrough\tO\nits\tO\neffect\tO\non\tO\nserum\tO\ncalcium\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nclose\tO\nparallel\tO\nbetween\tO\nthe\tO\neffect\tT-0\nof\tT-0\nvitamin\tO\nD\tO\ndose\tO\non\tO\nartery\tO\ncalcification\tO\nand\tO\nthe\tO\neffect\tT-3\nof\tT-3\nvitamin\tO\nD\tO\ndose\tO\non\tO\nthe\tO\nelevation\tT-1\nof\tT-1\nserum\tO\ncalcium\tO\n,\tO\nwhich\tO\nsuggests\tO\nthat\tO\nvitamin\tO\nD\tO\nmay\tT-4\ninduce\tT-4\nartery\tB-Disease\ncalcification\tI-Disease\nthrough\tO\nits\tO\neffect\tO\non\tO\nserum\tO\ncalcium\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nclose\tO\nparallel\tO\nbetween\tO\nthe\tO\neffect\tT-0\nof\tO\nvitamin\tO\nD\tO\ndose\tO\non\tO\nartery\tO\ncalcification\tO\nand\tO\nthe\tO\neffect\tT-1\nof\tO\nvitamin\tO\nD\tO\ndose\tO\non\tO\nthe\tO\nelevation\tO\nof\tO\nserum\tO\ncalcium\tO\n,\tO\nwhich\tO\nsuggests\tO\nthat\tO\nvitamin\tO\nD\tO\nmay\tO\ninduce\tT-3\nartery\tO\ncalcification\tO\nthrough\tO\nits\tO\neffect\tT-2\non\tO\nserum\tT-4\ncalcium\tB-Chemical\n.\tO\n\nBecause\tO\nWarfarin\tB-Chemical\ntreatment\tT-0\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nelevation\tO\nin\tO\nserum\tO\ncalcium\tO\nproduced\tO\nby\tO\nvitamin\tO\nD\tO\n,\tO\nthe\tO\nsynergy\tO\nbetween\tO\nWarfarin\tO\nand\tO\nvitamin\tO\nD\tO\nis\tO\nprobably\tO\nbest\tO\nexplained\tO\nby\tO\nthe\tO\nhypothesis\tO\nthat\tO\nWarfarin\tO\ninhibits\tO\nthe\tO\nactivity\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nas\tO\na\tO\ncalcification\tO\ninhibitor\tO\n.\tO\n\nBecause\tO\nWarfarin\tO\ntreatment\tO\nhad\tO\nno\tO\neffect\tT-1\non\tT-1\nthe\tO\nelevation\tO\nin\tO\nserum\tT-0\ncalcium\tB-Chemical\nproduced\tT-2\nby\tT-2\nvitamin\tO\nD\tO\n,\tO\nthe\tO\nsynergy\tO\nbetween\tO\nWarfarin\tO\nand\tO\nvitamin\tO\nD\tO\nis\tO\nprobably\tO\nbest\tO\nexplained\tO\nby\tO\nthe\tO\nhypothesis\tO\nthat\tO\nWarfarin\tO\ninhibits\tO\nthe\tO\nactivity\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nas\tO\na\tO\ncalcification\tO\ninhibitor\tO\n.\tO\n\nBecause\tO\nWarfarin\tO\ntreatment\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nelevation\tO\nin\tO\nserum\tO\ncalcium\tO\nproduced\tT-1\nby\tT-1\nvitamin\tB-Chemical\nD\tI-Chemical\n,\tO\nthe\tO\nsynergy\tO\nbetween\tO\nWarfarin\tO\nand\tO\nvitamin\tO\nD\tO\nis\tO\nprobably\tO\nbest\tO\nexplained\tO\nby\tO\nthe\tO\nhypothesis\tO\nthat\tO\nWarfarin\tO\ninhibits\tO\nthe\tO\nactivity\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nas\tO\na\tO\ncalcification\tO\ninhibitor\tO\n.\tO\n\nBecause\tO\nWarfarin\tO\ntreatment\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nelevation\tT-3\nin\tT-3\nserum\tO\ncalcium\tO\nproduced\tO\nby\tO\nvitamin\tO\nD\tO\n,\tO\nthe\tO\nsynergy\tO\nbetween\tT-0\nWarfarin\tB-Chemical\nand\tO\nvitamin\tO\nD\tO\nis\tO\nprobably\tO\nbest\tO\nexplained\tT-1\nby\tO\nthe\tO\nhypothesis\tT-2\nthat\tO\nWarfarin\tO\ninhibits\tT-4\nthe\tO\nactivity\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nas\tO\na\tO\ncalcification\tO\ninhibitor\tO\n.\tO\n\nBecause\tO\nWarfarin\tO\ntreatment\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nelevation\tO\nin\tO\nserum\tO\ncalcium\tO\nproduced\tO\nby\tO\nvitamin\tO\nD\tO\n,\tO\nthe\tO\nsynergy\tT-1\nbetween\tT-1\nWarfarin\tT-0\nand\tT-0\nvitamin\tB-Chemical\nD\tI-Chemical\nis\tO\nprobably\tO\nbest\tO\nexplained\tO\nby\tO\nthe\tO\nhypothesis\tO\nthat\tO\nWarfarin\tO\ninhibits\tO\nthe\tO\nactivity\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nas\tO\na\tO\ncalcification\tO\ninhibitor\tO\n.\tO\n\nBecause\tO\nWarfarin\tO\ntreatment\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nelevation\tO\nin\tO\nserum\tO\ncalcium\tO\nproduced\tO\nby\tO\nvitamin\tO\nD\tO\n,\tO\nthe\tO\nsynergy\tO\nbetween\tO\nWarfarin\tO\nand\tO\nvitamin\tO\nD\tO\nis\tO\nprobably\tO\nbest\tO\nexplained\tO\nby\tO\nthe\tO\nhypothesis\tO\nthat\tO\nWarfarin\tB-Chemical\ninhibits\tT-1\nthe\tO\nactivity\tT-0\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nas\tO\na\tO\ncalcification\tO\ninhibitor\tO\n.\tT-0\n\nBecause\tO\nWarfarin\tO\ntreatment\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nelevation\tO\nin\tO\nserum\tO\ncalcium\tO\nproduced\tT-0\nby\tT-0\nvitamin\tO\nD\tO\n,\tO\nthe\tO\nsynergy\tO\nbetween\tO\nWarfarin\tO\nand\tO\nvitamin\tO\nD\tO\nis\tO\nprobably\tO\nbest\tO\nexplained\tO\nby\tO\nthe\tO\nhypothesis\tO\nthat\tO\nWarfarin\tO\ninhibits\tT-1\nthe\tO\nactivity\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nas\tO\na\tO\ncalcification\tB-Disease\ninhibitor\tT-2\n.\tO\n\nHigh\tO\nlevels\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\nfound\tO\nat\tO\nsites\tT-0\nof\tT-0\nartery\tB-Disease\ncalcification\tI-Disease\nin\tO\nrats\tO\ntreated\tT-1\nwith\tT-1\nvitamin\tO\nD\tO\nplus\tO\nWarfarin\tO\n,\tO\nand\tO\nchemical\tO\nanalysis\tO\nshowed\tT-2\nthat\tT-2\nthe\tO\nprotein\tO\nthat\tO\naccumulated\tT-3\nwas\tO\nindeed\tO\nnot\tO\ngamma\tO\n-\tO\ncarboxylated\tO\n.\tO\n\nHigh\tO\nlevels\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\nfound\tO\nat\tO\nsites\tO\nof\tO\nartery\tO\ncalcification\tO\nin\tO\nrats\tO\ntreated\tT-1\nwith\tT-1\nvitamin\tB-Chemical\nD\tI-Chemical\nplus\tT-2\nWarfarin\tO\n,\tO\nand\tO\nchemical\tO\nanalysis\tO\nshowed\tT-0\nthat\tO\nthe\tO\nprotein\tO\nthat\tO\naccumulated\tO\nwas\tO\nindeed\tO\nnot\tO\ngamma\tO\n-\tO\ncarboxylated\tO\n.\tO\n\nHigh\tO\nlevels\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\nfound\tO\nat\tO\nsites\tO\nof\tO\nartery\tO\ncalcification\tO\nin\tO\nrats\tO\ntreated\tT-0\nwith\tT-0\nvitamin\tO\nD\tO\nplus\tO\nWarfarin\tB-Chemical\n,\tO\nand\tO\nchemical\tO\nanalysis\tO\nshowed\tO\nthat\tO\nthe\tO\nprotein\tO\nthat\tO\naccumulated\tO\nwas\tO\nindeed\tO\nnot\tO\ngamma\tO\n-\tO\ncarboxylated\tO\n.\tO\n\nHigh\tO\nlevels\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\nfound\tO\nat\tO\nsites\tO\nof\tO\nartery\tO\ncalcification\tO\nin\tO\nrats\tT-2\ntreated\tT-2\nwith\tT-0\nvitamin\tO\nD\tO\nplus\tO\nWarfarin\tO\n,\tO\nand\tO\nchemical\tT-3\nanalysis\tT-3\nshowed\tO\nthat\tO\nthe\tO\nprotein\tO\nthat\tO\naccumulated\tT-1\nwas\tO\nindeed\tO\nnot\tO\ngamma\tB-Chemical\n-\tI-Chemical\ncarboxylated\tI-Chemical\n.\tO\n\nThese\tO\nobservations\tO\nindicate\tO\nthat\tO\nalthough\tT-0\nthe\tT-0\ngamma\tB-Chemical\n-\tI-Chemical\ncarboxyglutamate\tI-Chemical\nresidues\tT-1\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\napparently\tO\nrequired\tO\nfor\tO\nits\tO\nfunction\tO\nas\tO\na\tO\ncalcification\tO\ninhibitor\tO\n,\tO\nthey\tO\nare\tO\nnot\tO\nrequired\tO\nfor\tO\nits\tO\naccumulation\tO\nat\tO\ncalcification\tO\nsites\tO\n.\tO\n\nThese\tO\nobservations\tO\nindicate\tO\nthat\tO\nalthough\tO\nthe\tO\ngamma\tO\n-\tO\ncarboxyglutamate\tO\nresidues\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\napparently\tO\nrequired\tO\nfor\tO\nits\tO\nfunction\tT-0\nas\tT-0\na\tT-0\ncalcification\tB-Disease\ninhibitor\tT-1\n,\tO\nthey\tO\nare\tO\nnot\tO\nrequired\tO\nfor\tO\nits\tO\naccumulation\tO\nat\tO\ncalcification\tO\nsites\tO\n.\tO\n\nThese\tO\nobservations\tT-2\nindicate\tT-2\nthat\tO\nalthough\tO\nthe\tO\ngamma\tO\n-\tO\ncarboxyglutamate\tO\nresidues\tO\nof\tO\nmatrix\tO\nGla\tO\nprotein\tO\nare\tO\napparently\tO\nrequired\tO\nfor\tO\nits\tO\nfunction\tO\nas\tO\na\tO\ncalcification\tO\ninhibitor\tO\n,\tO\nthey\tO\nare\tO\nnot\tO\nrequired\tO\nfor\tO\nits\tO\naccumulation\tO\nat\tT-0\ncalcification\tB-Disease\nsites\tT-1\n.\tO\n\nApomorphine\tB-Chemical\n,\tO\na\tO\nnonselective\tO\ndopamine\tO\nagonist\tO\n,\tO\nwas\tT-0\nselected\tT-0\ndue\tO\nto\tO\nits\tO\nbiphasic\tO\nbehavioral\tO\neffects\tO\n,\tO\nits\tO\nability\tO\nto\tO\ninduce\tO\nhypothermia\tO\n,\tO\nand\tO\nto\tO\nproduce\tO\ndistinct\tO\nchanges\tO\nto\tO\ndopamine\tO\nturnover\tO\nin\tO\nthe\tO\nrodent\tO\nbrain\tO\n.\tO\n\nApomorphine\tO\n,\tO\na\tO\nnonselective\tO\ndopamine\tB-Chemical\nagonist\tI-Chemical\n,\tO\nwas\tT-0\nselected\tT-0\ndue\tO\nto\tO\nits\tO\nbiphasic\tO\nbehavioral\tO\neffects\tO\n,\tO\nits\tO\nability\tO\nto\tO\ninduce\tO\nhypothermia\tO\n,\tO\nand\tO\nto\tO\nproduce\tO\ndistinct\tO\nchanges\tO\nto\tO\ndopamine\tO\nturnover\tO\nin\tO\nthe\tO\nrodent\tO\nbrain\tO\n.\tO\n\nApomorphine\tO\n,\tO\na\tO\nnonselective\tO\ndopamine\tO\nagonist\tO\n,\tO\nwas\tO\nselected\tO\ndue\tO\nto\tO\nits\tO\nbiphasic\tO\nbehavioral\tO\neffects\tO\n,\tO\nits\tO\nability\tO\nto\tO\ninduce\tT-0\nhypothermia\tB-Disease\n,\tT-1\nand\tT-1\nto\tT-1\nproduce\tT-1\ndistinct\tO\nchanges\tO\nto\tO\ndopamine\tO\nturnover\tO\nin\tO\nthe\tO\nrodent\tO\nbrain\tO\n.\tO\n\nApomorphine\tO\n,\tO\na\tO\nnonselective\tT-0\ndopamine\tO\nagonist\tO\n,\tO\nwas\tO\nselected\tO\ndue\tO\nto\tO\nits\tO\nbiphasic\tO\nbehavioral\tO\neffects\tO\n,\tO\nits\tO\nability\tO\nto\tO\ninduce\tT-1\nhypothermia\tO\n,\tO\nand\tO\nto\tO\nproduce\tO\ndistinct\tO\nchanges\tT-2\nto\tT-2\ndopamine\tB-Chemical\nturnover\tO\nin\tO\nthe\tO\nrodent\tO\nbrain\tO\n.\tO\n\nFrom\tO\nsuch\tO\nexperiments\tO\nthere\tO\nis\tO\nevidence\tO\nthat\tO\ncharacterization\tO\nand\tO\ndetection\tT-1\nof\tT-1\napomorphine\tB-Chemical\n-\tO\ninduced\tT-2\nactivity\tO\nin\tO\nrodents\tO\ncritically\tO\ndepends\tT-0\nupon\tO\nthe\tO\ntest\tO\nconditions\tO\nemployed\tO\n.\tO\n\nIn\tO\nrats\tO\n,\tO\ndetection\tT-3\nof\tT-3\napomorphine\tB-Chemical\n-\tO\ninduced\tT-4\nhyperactivity\tO\nwas\tO\nfacilitated\tO\nby\tO\na\tO\nperiod\tO\nof\tO\nacclimatization\tO\nto\tO\nthe\tO\ntest\tO\nconditions\tO\n.\tO\n\nIn\tO\nrats\tO\n,\tO\ndetection\tO\nof\tO\napomorphine\tO\n-\tO\ninduced\tT-0\nhyperactivity\tB-Disease\nwas\tT-1\nfacilitated\tT-1\nby\tO\na\tO\nperiod\tO\nof\tO\nacclimatization\tO\nto\tO\nthe\tO\ntest\tO\nconditions\tO\n.\tO\n\nMoreover\tO\n,\tO\ntest\tO\nconditions\tO\ncan\tO\nimpact\tT-0\nupon\tO\nother\tO\nphysiological\tO\nresponses\tO\nto\tO\napomorphine\tB-Chemical\nsuch\tO\nas\tO\ndrug\tO\n-\tO\ninduced\tT-1\nhypothermia\tO\n.\tO\n\nMoreover\tO\n,\tO\ntest\tO\nconditions\tO\ncan\tO\nimpact\tT-1\nupon\tO\nother\tO\nphysiological\tO\nresponses\tO\nto\tO\napomorphine\tO\nsuch\tO\nas\tO\ndrug\tO\n-\tO\ninduced\tT-2\nhypothermia\tB-Disease\n.\tO\n\nIn\tO\nmice\tO\n,\tO\napomorphine\tB-Chemical\nproduced\tT-0\nqualitatively\tO\ndifferent\tO\nresponses\tT-1\nunder\tO\nnovel\tO\nconditions\tO\nwhen\tO\ncompared\tO\nto\tO\nthose\tO\nbehaviors\tO\nelicited\tO\nin\tO\nthe\tO\nhome\tO\ntest\tO\ncage\tO\n.\tO\n\nBy\tT-1\ncontrast\tT-1\n,\tO\napomorphine\tB-Chemical\n-\tT-0\ninduced\tT-0\nlocomotion\tO\nwas\tO\nmore\tO\nprominent\tO\nin\tO\nthe\tO\nnovel\tO\nexploratory\tO\nbox\tO\n.\tO\n\nDopamine\tB-Chemical\nturnover\tT-1\nratios\tT-1\n(\tO\nDOPAC\tO\n:\tO\nDA\tO\nand\tO\nHVA\tO\n:\tO\nDA\tO\n)\tO\nwere\tO\nfound\tO\nto\tO\nbe\tO\nlower\tO\nin\tO\nthose\tO\nanimals\tO\nexposed\tT-0\nto\tT-0\nthe\tO\nexploratory\tO\nbox\tO\nwhen\tO\ncompared\tO\nto\tO\ntheir\tO\nhome\tO\ncage\tO\ncounterparts\tO\n.\tO\n\nDopamine\tO\nturnover\tT-1\nratios\tT-1\n(\tO\nDOPAC\tB-Chemical\n:\tO\nDA\tO\nand\tO\nHVA\tO\n:\tO\nDA\tO\n)\tO\nwere\tT-0\nfound\tT-0\nto\tO\nbe\tO\nlower\tO\nin\tO\nthose\tO\nanimals\tO\nexposed\tO\nto\tO\nthe\tO\nexploratory\tO\nbox\tO\nwhen\tO\ncompared\tO\nto\tO\ntheir\tO\nhome\tO\ncage\tO\ncounterparts\tO\n.\tO\n\nDopamine\tO\nturnover\tO\nratios\tO\n(\tO\nDOPAC\tO\n:\tO\nDA\tO\nand\tO\nHVA\tB-Chemical\n:\tO\nDA\tO\n)\tO\nwere\tO\nfound\tO\nto\tO\nbe\tO\nlower\tO\nin\tO\nthose\tO\nanimals\tO\nexposed\tT-0\nto\tT-0\nthe\tO\nexploratory\tO\nbox\tO\nwhen\tO\ncompared\tO\nto\tO\ntheir\tO\nhome\tO\ncage\tO\ncounterparts\tO\n.\tO\n\nDopamine\tO\nturnover\tO\nratios\tO\n(\tO\nDOPAC\tO\n:\tO\nDA\tO\nand\tO\nHVA\tO\n:\tO\nDA\tB-Chemical\n)\tO\nwere\tT-1\nfound\tT-1\nto\tO\nbe\tO\nlower\tO\nin\tO\nthose\tO\nanimals\tO\nexposed\tT-0\nto\tO\nthe\tO\nexploratory\tO\nbox\tO\nwhen\tO\ncompared\tO\nto\tO\ntheir\tO\nhome\tO\ncage\tO\ncounterparts\tO\n.\tO\n\nHowever\tO\n,\tO\napomorphine\tB-Chemical\n-\tO\ninduced\tT-1\nreductions\tO\nin\tO\nstriatal\tO\ndopamine\tO\nturnover\tO\nwere\tO\ndetected\tT-2\nin\tO\nboth\tO\nnovel\tO\nand\tO\nhome\tO\ncage\tO\nenvironments\tO\n.\tO\n\nHowever\tO\n,\tO\napomorphine\tO\n-\tO\ninduced\tO\nreductions\tT-0\nin\tT-0\nstriatal\tO\ndopamine\tB-Chemical\nturnover\tO\nwere\tO\ndetected\tO\nin\tO\nboth\tO\nnovel\tO\nand\tO\nhome\tO\ncage\tO\nenvironments\tO\n.\tO\n\nHemolysis\tB-Disease\nof\tT-1\nhuman\tT-1\nerythrocytes\tT-1\ninduced\tO\nby\tO\ntamoxifen\tO\nis\tO\nrelated\tO\nto\tO\ndisruption\tO\nof\tO\nmembrane\tO\nstructure\tO\n.\tO\n\nHemolysis\tO\nof\tO\nhuman\tO\nerythrocytes\tO\ninduced\tT-1\nby\tT-1\ntamoxifen\tB-Chemical\nis\tT-2\nrelated\tT-2\nto\tT-0\ndisruption\tO\nof\tO\nmembrane\tO\nstructure\tO\n.\tO\n\nTamoxifen\tB-Chemical\n(\tO\nTAM\tO\n)\tO\n,\tO\nthe\tO\nantiestrogenic\tO\ndrug\tT-0\nmost\tO\nwidely\tO\nprescribed\tO\nin\tO\nthe\tO\nchemotherapy\tO\nof\tO\nbreast\tO\ncancer\tO\n,\tO\ninduces\tT-2\nchanges\tO\nin\tO\nnormal\tO\ndiscoid\tO\nshape\tO\nof\tO\nerythrocytes\tO\nand\tO\nhemolytic\tO\nanemia\tO\n.\tO\n\nTamoxifen\tT-0\n(\tO\nTAM\tB-Chemical\n)\tO\n,\tT-1\nthe\tT-1\nantiestrogenic\tT-1\ndrug\tT-1\nmost\tO\nwidely\tO\nprescribed\tO\nin\tO\nthe\tO\nchemotherapy\tO\nof\tO\nbreast\tO\ncancer\tO\n,\tO\ninduces\tO\nchanges\tO\nin\tO\nnormal\tO\ndiscoid\tO\nshape\tO\nof\tO\nerythrocytes\tO\nand\tO\nhemolytic\tO\nanemia\tO\n.\tO\n\nTamoxifen\tO\n(\tO\nTAM\tO\n)\tO\n,\tO\nthe\tO\nantiestrogenic\tO\ndrug\tO\nmost\tO\nwidely\tO\nprescribed\tO\nin\tO\nthe\tO\nchemotherapy\tT-0\nof\tT-0\nbreast\tB-Disease\ncancer\tI-Disease\n,\tO\ninduces\tO\nchanges\tO\nin\tO\nnormal\tO\ndiscoid\tO\nshape\tO\nof\tO\nerythrocytes\tO\nand\tO\nhemolytic\tO\nanemia\tO\n.\tO\n\nTamoxifen\tO\n(\tO\nTAM\tO\n)\tO\n,\tO\nthe\tO\nantiestrogenic\tO\ndrug\tO\nmost\tO\nwidely\tO\nprescribed\tO\nin\tO\nthe\tO\nchemotherapy\tO\nof\tO\nbreast\tO\ncancer\tO\n,\tO\ninduces\tT-0\nchanges\tT-0\nin\tT-0\nnormal\tO\ndiscoid\tO\nshape\tO\nof\tO\nerythrocytes\tO\nand\tO\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\neffects\tT-0\nof\tT-0\nTAM\tB-Chemical\non\tT-1\nisolated\tT-1\nhuman\tO\nerythrocytes\tO\n,\tO\nattempting\tO\nto\tO\nidentify\tO\nthe\tO\nunderlying\tO\nmechanisms\tO\non\tO\nTAM\tO\n-\tO\ninduced\tO\nhemolytic\tO\nanemia\tO\nand\tO\nthe\tO\ninvolvement\tO\nof\tO\nbiomembranes\tO\nin\tO\nits\tO\ncytostatic\tO\naction\tO\nmechanisms\tO\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\neffects\tO\nof\tO\nTAM\tO\non\tO\nisolated\tO\nhuman\tO\nerythrocytes\tO\n,\tO\nattempting\tO\nto\tO\nidentify\tO\nthe\tO\nunderlying\tO\nmechanisms\tT-1\non\tT-1\nTAM\tB-Chemical\n-\tO\ninduced\tT-0\nhemolytic\tO\nanemia\tO\nand\tO\nthe\tO\ninvolvement\tO\nof\tO\nbiomembranes\tO\nin\tO\nits\tO\ncytostatic\tO\naction\tO\nmechanisms\tO\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\neffects\tO\nof\tO\nTAM\tO\non\tO\nisolated\tO\nhuman\tO\nerythrocytes\tO\n,\tO\nattempting\tO\nto\tO\nidentify\tO\nthe\tO\nunderlying\tO\nmechanisms\tO\non\tO\nTAM\tT-0\n-\tT-0\ninduced\tT-1\nhemolytic\tB-Disease\nanemia\tI-Disease\nand\tO\nthe\tO\ninvolvement\tO\nof\tO\nbiomembranes\tO\nin\tO\nits\tO\ncytostatic\tO\naction\tO\nmechanisms\tO\n.\tO\n\nTAM\tB-Chemical\ninduces\tT-0\nhemolysis\tO\nof\tO\nerythrocytes\tO\nas\tO\na\tO\nfunction\tO\nof\tO\nconcentration\tO\n.\tO\n\nTAM\tT-1\ninduces\tT-1\nhemolysis\tB-Disease\nof\tT-2\nerythrocytes\tT-2\nas\tO\na\tO\nfunction\tO\nof\tO\nconcentration\tO\n.\tO\n\nThe\tO\nextension\tT-0\nof\tT-0\nhemolysis\tB-Disease\nis\tT-1\nvariable\tT-1\nwith\tO\nerythrocyte\tO\nsamples\tO\n,\tO\nbut\tO\n12\tO\n.\tO\n5\tO\nmicroM\tO\nTAM\tO\ninduces\tO\ntotal\tO\nhemolysis\tO\nof\tO\nall\tO\ntested\tO\nsuspensions\tO\n.\tO\n\nThe\tO\nextension\tO\nof\tO\nhemolysis\tO\nis\tO\nvariable\tO\nwith\tO\nerythrocyte\tO\nsamples\tO\n,\tO\nbut\tO\n12\tO\n.\tO\n5\tO\nmicroM\tO\nTAM\tB-Chemical\ninduces\tT-0\ntotal\tO\nhemolysis\tO\nof\tO\nall\tO\ntested\tO\nsuspensions\tO\n.\tO\n\nThe\tO\nextension\tO\nof\tO\nhemolysis\tO\nis\tO\nvariable\tO\nwith\tO\nerythrocyte\tO\nsamples\tO\n,\tO\nbut\tO\n12\tO\n.\tO\n5\tO\nmicroM\tO\nTAM\tO\ninduces\tT-0\ntotal\tT-0\nhemolysis\tB-Disease\nof\tO\nall\tO\ntested\tO\nsuspensions\tO\n.\tO\n\nDespite\tO\ninducing\tT-2\nextensive\tO\nerythrocyte\tO\nlysis\tO\n,\tO\nTAM\tB-Chemical\ndoes\tT-1\nnot\tT-1\nshift\tT-1\nthe\tO\nosmotic\tO\nfragility\tO\ncurves\tO\nof\tO\nerythrocytes\tO\n.\tO\n\nThe\tT-0\nhemolytic\tB-Disease\neffect\tO\nof\tO\nTAM\tO\nis\tO\nprevented\tO\nby\tO\nlow\tO\nconcentrations\tO\nof\tO\nalpha\tO\n-\tO\ntocopherol\tO\n(\tO\nalpha\tO\n-\tO\nT\tO\n)\tO\nand\tO\nalpha\tO\n-\tO\ntocopherol\tO\nacetate\tO\n(\tO\nalpha\tO\n-\tO\nTAc\tO\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tO\n)\tO\nindicating\tO\nthat\tO\nTAM\tO\n-\tO\ninduced\tO\nhemolysis\tO\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tO\nmembrane\tO\ndamage\tO\n.\tO\n\nThe\tO\nhemolytic\tT-2\neffect\tT-2\nof\tT-2\nTAM\tB-Chemical\nis\tO\nprevented\tT-1\nby\tT-1\nlow\tO\nconcentrations\tO\nof\tO\nalpha\tO\n-\tO\ntocopherol\tO\n(\tO\nalpha\tO\n-\tO\nT\tO\n)\tO\nand\tO\nalpha\tO\n-\tO\ntocopherol\tO\nacetate\tO\n(\tO\nalpha\tO\n-\tO\nTAc\tO\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tO\n)\tO\nindicating\tO\nthat\tO\nTAM\tO\n-\tO\ninduced\tO\nhemolysis\tO\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tO\nmembrane\tO\ndamage\tO\n.\tO\n\nThe\tO\nhemolytic\tO\neffect\tO\nof\tO\nTAM\tO\nis\tO\nprevented\tT-0\nby\tO\nlow\tO\nconcentrations\tT-2\nof\tT-2\nalpha\tB-Chemical\n-\tI-Chemical\ntocopherol\tI-Chemical\n(\tT-3\nalpha\tT-3\n-\tT-3\nT\tT-3\n)\tT-3\nand\tO\nalpha\tO\n-\tO\ntocopherol\tO\nacetate\tO\n(\tO\nalpha\tO\n-\tO\nTAc\tO\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tO\n)\tO\nindicating\tO\nthat\tO\nTAM\tO\n-\tO\ninduced\tT-1\nhemolysis\tO\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tO\nmembrane\tO\ndamage\tO\n.\tO\n\nThe\tO\nhemolytic\tO\neffect\tO\nof\tO\nTAM\tO\nis\tO\nprevented\tT-1\nby\tO\nlow\tO\nconcentrations\tT-0\nof\tT-0\nalpha\tO\n-\tO\ntocopherol\tO\n(\tO\nalpha\tB-Chemical\n-\tI-Chemical\nT\tI-Chemical\n)\tO\nand\tO\nalpha\tO\n-\tO\ntocopherol\tO\nacetate\tO\n(\tO\nalpha\tO\n-\tO\nTAc\tO\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tO\n)\tO\nindicating\tO\nthat\tO\nTAM\tO\n-\tO\ninduced\tO\nhemolysis\tO\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tO\nmembrane\tO\ndamage\tO\n.\tO\n\nThe\tO\nhemolytic\tO\neffect\tT-2\nof\tT-2\nTAM\tO\nis\tO\nprevented\tO\nby\tO\nlow\tO\nconcentrations\tT-0\nof\tO\nalpha\tO\n-\tO\ntocopherol\tO\n(\tO\nalpha\tO\n-\tO\nT\tO\n)\tO\nand\tO\nalpha\tB-Chemical\n-\tI-Chemical\ntocopherol\tI-Chemical\nacetate\tI-Chemical\n(\tO\nalpha\tO\n-\tO\nTAc\tO\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tO\n)\tO\nindicating\tT-3\nthat\tT-3\nTAM\tO\n-\tO\ninduced\tO\nhemolysis\tO\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tT-1\nmembrane\tO\ndamage\tO\n.\tO\n\nThe\tO\nhemolytic\tO\neffect\tO\nof\tO\nTAM\tO\nis\tO\nprevented\tO\nby\tO\nlow\tO\nconcentrations\tT-0\nof\tO\nalpha\tO\n-\tO\ntocopherol\tO\n(\tO\nalpha\tO\n-\tO\nT\tO\n)\tO\nand\tO\nalpha\tO\n-\tO\ntocopherol\tT-2\nacetate\tT-2\n(\tO\nalpha\tB-Chemical\n-\tI-Chemical\nTAc\tI-Chemical\n)\tO\n(\tT-3\ninactivated\tT-3\nfunctional\tT-3\nhydroxyl\tT-3\n)\tT-3\nindicating\tO\nthat\tO\nTAM\tO\n-\tO\ninduced\tO\nhemolysis\tO\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tT-1\nmembrane\tO\ndamage\tO\n.\tO\n\nThe\tO\nhemolytic\tO\neffect\tO\nof\tO\nTAM\tO\nis\tO\nprevented\tO\nby\tO\nlow\tO\nconcentrations\tO\nof\tO\nalpha\tO\n-\tO\ntocopherol\tO\n(\tO\nalpha\tO\n-\tO\nT\tO\n)\tO\nand\tO\nalpha\tO\n-\tO\ntocopherol\tO\nacetate\tO\n(\tO\nalpha\tO\n-\tO\nTAc\tO\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tB-Chemical\n)\tO\nindicating\tO\nthat\tO\nTAM\tO\n-\tO\ninduced\tT-0\nhemolysis\tO\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tO\nmembrane\tO\ndamage\tO\n.\tO\n\nThe\tO\nhemolytic\tO\neffect\tO\nof\tO\nTAM\tO\nis\tO\nprevented\tO\nby\tO\nlow\tO\nconcentrations\tO\nof\tO\nalpha\tO\n-\tO\ntocopherol\tO\n(\tO\nalpha\tO\n-\tO\nT\tO\n)\tO\nand\tO\nalpha\tO\n-\tO\ntocopherol\tO\nacetate\tO\n(\tO\nalpha\tO\n-\tO\nTAc\tO\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tO\n)\tO\nindicating\tT-0\nthat\tT-0\nTAM\tB-Chemical\n-\tO\ninduced\tT-1\nhemolysis\tO\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tO\nmembrane\tO\ndamage\tO\n.\tO\n\nThe\tO\nhemolytic\tO\neffect\tO\nof\tO\nTAM\tO\nis\tO\nprevented\tO\nby\tO\nlow\tO\nconcentrations\tO\nof\tO\nalpha\tO\n-\tO\ntocopherol\tO\n(\tO\nalpha\tO\n-\tO\nT\tO\n)\tO\nand\tO\nalpha\tO\n-\tO\ntocopherol\tO\nacetate\tO\n(\tO\nalpha\tO\n-\tO\nTAc\tO\n)\tO\n(\tO\ninactivated\tO\nfunctional\tO\nhydroxyl\tO\n)\tO\nindicating\tO\nthat\tO\nTAM\tO\n-\tO\ninduced\tT-0\nhemolysis\tB-Disease\nis\tO\nnot\tO\nrelated\tO\nto\tO\noxidative\tO\nmembrane\tO\ndamage\tO\n.\tO\n\nThis\tO\nwas\tO\nfurther\tO\nevidenced\tO\nby\tO\nabsence\tT-1\nof\tT-1\noxygen\tB-Chemical\nconsumption\tT-2\nand\tO\nhemoglobin\tO\noxidation\tO\nboth\tO\ndetermined\tO\nin\tO\nparallel\tO\nwith\tO\nTAM\tO\n-\tO\ninduced\tT-0\nhemolysis\tO\n.\tO\n\nThis\tO\nwas\tO\nfurther\tO\nevidenced\tO\nby\tO\nabsence\tO\nof\tO\noxygen\tO\nconsumption\tO\nand\tO\nhemoglobin\tO\noxidation\tO\nboth\tO\ndetermined\tT-0\nin\tT-0\nparallel\tT-0\nwith\tO\nTAM\tB-Chemical\n-\tT-2\ninduced\tT-2\nhemolysis\tO\n.\tO\n\nThis\tO\nwas\tO\nfurther\tO\nevidenced\tO\nby\tO\nabsence\tO\nof\tO\noxygen\tO\nconsumption\tO\nand\tO\nhemoglobin\tO\noxidation\tO\nboth\tO\ndetermined\tO\nin\tO\nparallel\tO\nwith\tO\nTAM\tO\n-\tO\ninduced\tT-0\nhemolysis\tB-Disease\n.\tO\n\nFurthermore\tO\n,\tO\nit\tO\nwas\tO\nobserved\tT-0\nthat\tT-0\nTAM\tB-Chemical\ninhibits\tO\nthe\tO\nperoxidation\tO\nof\tO\nhuman\tO\nerythrocytes\tO\ninduced\tO\nby\tO\nAAPH\tO\n,\tO\nthus\tO\nruling\tO\nout\tO\nTAM\tO\n-\tO\ninduced\tO\ncell\tO\noxidative\tO\nstress\tO\n.\tO\n\nFurthermore\tO\n,\tO\nit\tO\nwas\tO\nobserved\tO\nthat\tO\nTAM\tO\ninhibits\tO\nthe\tO\nperoxidation\tO\nof\tO\nhuman\tO\nerythrocytes\tO\ninduced\tT-0\nby\tT-0\nAAPH\tB-Chemical\n,\tO\nthus\tO\nruling\tO\nout\tO\nTAM\tO\n-\tO\ninduced\tO\ncell\tO\noxidative\tO\nstress\tO\n.\tO\n\nFurthermore\tO\n,\tO\nit\tT-1\nwas\tT-1\nobserved\tT-1\nthat\tT-0\nTAM\tO\ninhibits\tT-2\nthe\tO\nperoxidation\tO\nof\tO\nhuman\tO\nerythrocytes\tO\ninduced\tO\nby\tO\nAAPH\tO\n,\tO\nthus\tO\nruling\tO\nout\tO\nTAM\tB-Chemical\n-\tO\ninduced\tT-3\ncell\tO\noxidative\tO\nstress\tO\n.\tO\n\nHemolysis\tB-Disease\ncaused\tT-0\nby\tT-0\nTAM\tO\nwas\tO\nnot\tO\npreceded\tO\nby\tO\nthe\tO\nleakage\tO\nof\tO\nK\tO\n(\tO\n+\tO\n)\tO\nfrom\tO\nthe\tO\ncells\tO\n,\tO\nalso\tO\nexcluding\tO\na\tO\ncolloid\tO\n-\tO\nosmotic\tO\ntype\tO\nmechanism\tO\nof\tO\nhemolysis\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\neffects\tO\non\tO\nosmotic\tO\nfragility\tO\ncurves\tO\n.\tO\n\nHemolysis\tO\ncaused\tT-0\nby\tT-0\nTAM\tB-Chemical\nwas\tO\nnot\tO\npreceded\tO\nby\tO\nthe\tO\nleakage\tO\nof\tO\nK\tO\n(\tO\n+\tO\n)\tO\nfrom\tO\nthe\tO\ncells\tO\n,\tO\nalso\tO\nexcluding\tO\na\tO\ncolloid\tO\n-\tO\nosmotic\tO\ntype\tO\nmechanism\tO\nof\tO\nhemolysis\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\neffects\tO\non\tO\nosmotic\tO\nfragility\tO\ncurves\tO\n.\tO\n\nHemolysis\tO\ncaused\tO\nby\tO\nTAM\tO\nwas\tO\nnot\tO\npreceded\tT-0\nby\tT-0\nthe\tO\nleakage\tO\nof\tO\nK\tB-Chemical\n(\tO\n+\tO\n)\tO\nfrom\tO\nthe\tO\ncells\tO\n,\tO\nalso\tO\nexcluding\tO\na\tO\ncolloid\tO\n-\tO\nosmotic\tO\ntype\tO\nmechanism\tO\nof\tO\nhemolysis\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\neffects\tO\non\tO\nosmotic\tO\nfragility\tO\ncurves\tO\n.\tO\n\nHemolysis\tO\ncaused\tO\nby\tO\nTAM\tO\nwas\tO\nnot\tT-1\npreceded\tT-1\nby\tT-1\nthe\tO\nleakage\tO\nof\tO\nK\tO\n(\tO\n+\tO\n)\tO\nfrom\tO\nthe\tO\ncells\tO\n,\tO\nalso\tO\nexcluding\tO\na\tO\ncolloid\tO\n-\tO\nosmotic\tO\ntype\tO\nmechanism\tT-0\nof\tT-0\nhemolysis\tB-Disease\n,\tO\naccording\tO\nto\tO\nthe\tO\neffects\tT-2\non\tT-2\nosmotic\tO\nfragility\tO\ncurves\tO\n.\tO\n\nHowever\tO\n,\tO\nTAM\tB-Chemical\ninduces\tT-0\nrelease\tO\nof\tO\nperipheral\tO\nproteins\tO\nof\tO\nmembrane\tO\n-\tO\ncytoskeleton\tO\nand\tO\ncytosol\tO\nproteins\tO\nessentially\tO\nbound\tO\nto\tO\nband\tO\n3\tO\n.\tO\n\nEither\tO\nalpha\tB-Chemical\n-\tI-Chemical\nT\tI-Chemical\nor\tO\nalpha\tO\n-\tO\nTAc\tO\nincreases\tT-0\nmembrane\tO\npacking\tO\nand\tO\nprevents\tT-1\nTAM\tO\npartition\tO\ninto\tO\nmodel\tO\nmembranes\tO\n.\tO\n\nEither\tO\nalpha\tO\n-\tO\nT\tO\nor\tT-1\nalpha\tB-Chemical\n-\tI-Chemical\nTAc\tI-Chemical\nincreases\tT-2\nmembrane\tO\npacking\tO\nand\tO\nprevents\tT-0\nTAM\tO\npartition\tO\ninto\tO\nmodel\tO\nmembranes\tO\n.\tO\n\nEither\tO\nalpha\tO\n-\tO\nT\tO\nor\tO\nalpha\tO\n-\tO\nTAc\tO\nincreases\tO\nmembrane\tO\npacking\tO\nand\tO\nprevents\tT-1\nTAM\tB-Chemical\npartition\tO\ninto\tT-0\nmodel\tT-0\nmembranes\tT-0\n.\tO\n\nThese\tO\neffects\tO\nsuggest\tO\nthat\tO\nthe\tO\nprotection\tT-1\nfrom\tT-1\nhemolysis\tB-Disease\nby\tO\ntocopherols\tO\nis\tO\nrelated\tO\nto\tO\na\tO\ndecreased\tO\nTAM\tO\nincorporation\tO\nin\tO\ncondensed\tO\nmembranes\tO\nand\tO\nthe\tO\nstructural\tO\ndamage\tO\nof\tO\nthe\tO\nerythrocyte\tO\nmembrane\tO\nis\tO\nconsequently\tO\navoided\tO\n.\tO\n\nThese\tO\neffects\tO\nsuggest\tO\nthat\tO\nthe\tO\nprotection\tO\nfrom\tO\nhemolysis\tO\nby\tO\ntocopherols\tB-Chemical\nis\tO\nrelated\tT-0\nto\tT-0\na\tO\ndecreased\tO\nTAM\tO\nincorporation\tO\nin\tO\ncondensed\tO\nmembranes\tO\nand\tO\nthe\tO\nstructural\tO\ndamage\tT-1\nof\tO\nthe\tO\nerythrocyte\tO\nmembrane\tO\nis\tO\nconsequently\tO\navoided\tO\n.\tO\n\nThese\tO\neffects\tO\nsuggest\tO\nthat\tO\nthe\tO\nprotection\tT-0\nfrom\tT-0\nhemolysis\tO\nby\tO\ntocopherols\tO\nis\tO\nrelated\tO\nto\tO\na\tO\ndecreased\tT-1\nTAM\tB-Chemical\nincorporation\tT-2\nin\tO\ncondensed\tO\nmembranes\tO\nand\tO\nthe\tO\nstructural\tO\ndamage\tO\nof\tO\nthe\tO\nerythrocyte\tO\nmembrane\tO\nis\tO\nconsequently\tO\navoided\tO\n.\tO\n\nTherefore\tO\n,\tO\nTAM\tB-Chemical\n-\tT-1\ninduced\tT-1\nhemolysis\tO\nresults\tO\nfrom\tO\na\tO\nstructural\tO\nperturbation\tO\nof\tO\nred\tO\ncell\tO\nmembrane\tO\n,\tO\nleading\tO\nto\tO\nchanges\tO\nin\tO\nthe\tO\nframework\tO\nof\tO\nthe\tO\nerythrocyte\tO\nmembrane\tO\nand\tO\nits\tO\ncytoskeleton\tO\ncaused\tO\nby\tO\nits\tO\nhigh\tO\npartition\tO\nin\tO\nthe\tO\nmembrane\tO\n.\tO\n\nTherefore\tO\n,\tO\nTAM\tO\n-\tO\ninduced\tT-0\nhemolysis\tB-Disease\nresults\tT-1\nfrom\tO\na\tO\nstructural\tO\nperturbation\tO\nof\tO\nred\tO\ncell\tO\nmembrane\tO\n,\tO\nleading\tO\nto\tO\nchanges\tO\nin\tO\nthe\tO\nframework\tO\nof\tO\nthe\tO\nerythrocyte\tO\nmembrane\tO\nand\tO\nits\tO\ncytoskeleton\tO\ncaused\tO\nby\tO\nits\tO\nhigh\tO\npartition\tO\nin\tO\nthe\tO\nmembrane\tO\n.\tO\n\nThese\tO\ndefects\tO\nexplain\tO\nthe\tO\nabnormal\tO\nerythrocyte\tO\nshape\tO\nand\tO\ndecreased\tO\nmechanical\tO\nstability\tO\npromoted\tT-0\nby\tT-0\nTAM\tB-Chemical\n,\tO\nresulting\tT-1\nin\tT-1\nhemolytic\tO\nanemia\tO\n.\tO\n\nThese\tO\ndefects\tO\nexplain\tO\nthe\tO\nabnormal\tO\nerythrocyte\tO\nshape\tO\nand\tO\ndecreased\tO\nmechanical\tT-0\nstability\tT-0\npromoted\tO\nby\tO\nTAM\tO\n,\tO\nresulting\tT-1\nin\tT-1\nhemolytic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nAdditionally\tO\n,\tO\nsince\tO\nmembrane\tO\nleakage\tO\nis\tO\na\tO\nfinal\tO\nstage\tO\nof\tO\ncytotoxicity\tO\n,\tO\nthe\tT-0\ndisruption\tT-0\nof\tT-0\nthe\tO\nstructural\tO\ncharacteristics\tO\nof\tO\nbiomembranes\tO\nby\tT-1\nTAM\tB-Chemical\nmay\tT-2\ncontribute\tT-2\nto\tO\nthe\tO\nmultiple\tO\nmechanisms\tO\nof\tO\nits\tO\nanticancer\tO\naction\tO\n.\tO\n\nChanges\tT-0\nof\tT-0\nsodium\tB-Chemical\nand\tT-1\nATP\tO\naffinities\tO\nof\tO\nthe\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nduring\tO\nand\tO\nafter\tO\nnitric\tO\noxide\tO\ndeficient\tO\nhypertension\tO\n.\tO\n\nChanges\tO\nof\tO\nsodium\tO\nand\tT-0\nATP\tB-Chemical\naffinities\tO\nof\tO\nthe\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nduring\tO\nand\tO\nafter\tO\nnitric\tO\noxide\tO\ndeficient\tO\nhypertension\tO\n.\tO\n\nChanges\tT-0\nof\tT-0\nsodium\tO\nand\tO\nATP\tO\naffinities\tT-1\nof\tT-1\nthe\tO\ncardiac\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nduring\tO\nand\tO\nafter\tO\nnitric\tO\noxide\tO\ndeficient\tO\nhypertension\tO\n.\tO\n\nChanges\tO\nof\tO\nsodium\tO\nand\tO\nATP\tO\naffinities\tO\nof\tO\nthe\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nduring\tT-0\nand\tO\nafter\tT-1\nnitric\tO\noxide\tO\ndeficient\tO\nhypertension\tO\n.\tO\n\nChanges\tT-1\nof\tT-1\nsodium\tO\nand\tO\nATP\tO\naffinities\tT-2\nof\tT-2\nthe\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nduring\tT-3\nand\tT-3\nafter\tT-3\nnitric\tB-Chemical\noxide\tI-Chemical\ndeficient\tT-0\nhypertension\tO\n.\tO\n\nChanges\tO\nof\tO\nsodium\tO\nand\tO\nATP\tO\naffinities\tO\nof\tO\nthe\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nduring\tO\nand\tO\nafter\tO\nnitric\tO\noxide\tO\ndeficient\tT-0\nhypertension\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\ncardiovascular\tO\nsystem\tO\n,\tO\nNO\tB-Chemical\nis\tT-0\ninvolved\tT-2\nin\tT-2\nthe\tO\nregulation\tT-1\nof\tO\na\tO\nvariety\tO\nof\tO\nfunctions\tO\n.\tO\n\nInhibition\tT-0\nof\tT-0\nNO\tB-Chemical\nsynthesis\tO\ninduces\tT-1\nsustained\tO\nhypertension\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tO\nsynthesis\tO\ninduces\tT-0\nsustained\tO\nhypertension\tB-Disease\n.\tO\n\nIn\tT-1\nseveral\tT-1\nmodels\tT-1\nof\tT-1\nhypertension\tB-Disease\n,\tO\nelevation\tO\nof\tO\nintracellular\tO\nsodium\tO\nlevel\tO\nwas\tO\ndocumented\tO\nin\tO\ncardiac\tO\ntissue\tO\n.\tO\n\nIn\tO\nseveral\tO\nmodels\tO\nof\tO\nhypertension\tO\n,\tO\nelevation\tT-1\nof\tT-1\nintracellular\tO\nsodium\tB-Chemical\nlevel\tT-0\nwas\tO\ndocumented\tO\nin\tO\ncardiac\tO\ntissue\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tT-3\nof\tT-3\nNa\tB-Chemical\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tT-0\nof\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tO\n-\tO\ndeficient\tO\nhypertension\tO\ninduced\tT-1\nin\tO\nrats\tO\nby\tO\nNO\tO\n-\tO\nsynthase\tO\ninhibition\tT-2\nwith\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nN\tO\n(\tO\nG\tO\n)\tO\n-\tO\nnitro\tO\n-\tO\nL\tO\n-\tO\narginine\tO\nmethyl\tO\nester\tO\n(\tO\nL\tO\n-\tO\nNAME\tO\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tO\nof\tO\nNa\tO\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tT-0\nof\tT-0\ncardiac\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tO\n-\tO\ndeficient\tO\nhypertension\tO\ninduced\tO\nin\tO\nrats\tO\nby\tO\nNO\tO\n-\tO\nsynthase\tO\ninhibition\tT-1\nwith\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nN\tO\n(\tO\nG\tO\n)\tO\n-\tO\nnitro\tO\n-\tO\nL\tO\n-\tO\narginine\tO\nmethyl\tO\nester\tO\n(\tO\nL\tO\n-\tO\nNAME\tO\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tO\nof\tO\nNa\tO\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tT-0\nof\tT-0\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tO\n-\tO\ndeficient\tO\nhypertension\tO\ninduced\tO\nin\tO\nrats\tO\nby\tO\nNO\tO\n-\tO\nsynthase\tO\ninhibition\tO\nwith\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nN\tO\n(\tO\nG\tO\n)\tO\n-\tO\nnitro\tO\n-\tO\nL\tO\n-\tO\narginine\tO\nmethyl\tO\nester\tO\n(\tO\nL\tO\n-\tO\nNAME\tO\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tO\nof\tO\nNa\tO\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tO\nof\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tB-Chemical\n-\tO\ndeficient\tO\nhypertension\tO\ninduced\tT-0\nin\tO\nrats\tO\nby\tO\nNO\tO\n-\tO\nsynthase\tO\ninhibition\tO\nwith\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nN\tO\n(\tO\nG\tO\n)\tO\n-\tO\nnitro\tO\n-\tO\nL\tO\n-\tO\narginine\tO\nmethyl\tO\nester\tO\n(\tO\nL\tO\n-\tO\nNAME\tO\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tO\nof\tO\nNa\tO\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tO\nof\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tO\n-\tO\ndeficient\tO\nhypertension\tB-Disease\ninduced\tT-0\nin\tO\nrats\tO\nby\tO\nNO\tO\n-\tO\nsynthase\tO\ninhibition\tO\nwith\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nN\tO\n(\tO\nG\tO\n)\tO\n-\tO\nnitro\tO\n-\tO\nL\tO\n-\tO\narginine\tO\nmethyl\tO\nester\tO\n(\tO\nL\tO\n-\tO\nNAME\tO\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tO\nof\tO\nNa\tO\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tO\nof\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tO\n-\tO\ndeficient\tO\nhypertension\tO\ninduced\tT-1\nin\tO\nrats\tO\nby\tT-2\nNO\tB-Chemical\n-\tT-0\nsynthase\tT-0\ninhibition\tO\nwith\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nN\tO\n(\tO\nG\tO\n)\tO\n-\tO\nnitro\tO\n-\tO\nL\tO\n-\tO\narginine\tO\nmethyl\tO\nester\tO\n(\tO\nL\tO\n-\tO\nNAME\tO\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tO\nof\tO\nNa\tO\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tO\nof\tO\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tO\n-\tO\ndeficient\tO\nhypertension\tO\ninduced\tT-0\nin\tT-0\nrats\tO\nby\tO\nNO\tO\n-\tO\nsynthase\tO\ninhibition\tO\nwith\tO\n40\tT-1\nmg\tT-1\n/\tT-1\nkg\tT-1\n/\tT-1\nday\tT-1\nN\tB-Chemical\n(\tI-Chemical\nG\tI-Chemical\n)\tI-Chemical\n-\tI-Chemical\nnitro\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nmethyl\tI-Chemical\nester\tI-Chemical\n(\tO\nL\tO\n-\tO\nNAME\tO\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nTo\tO\nassess\tO\nthe\tO\nmolecular\tO\nbasis\tO\nof\tO\ndisturbances\tO\nin\tO\ntransmembraneous\tO\ntransport\tO\nof\tO\nNa\tO\n+\tO\n,\tO\nwe\tO\nstudied\tO\nthe\tO\nresponse\tT-0\nof\tT-0\ncardiac\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nto\tO\nNO\tO\n-\tO\ndeficient\tO\nhypertension\tO\ninduced\tT-1\nin\tO\nrats\tO\nby\tO\nNO\tO\n-\tO\nsynthase\tO\ninhibition\tT-2\nwith\tO\n40\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nN\tO\n(\tO\nG\tO\n)\tO\n-\tO\nnitro\tO\n-\tO\nL\tO\n-\tO\narginine\tO\nmethyl\tO\nester\tO\n(\tO\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n)\tO\nfor\tO\n4\tO\nfour\tO\nweeks\tO\n.\tO\n\nAfter\tO\n4\tO\n-\tO\nweek\tO\nadministration\tT-2\nof\tT-2\nL\tB-Chemical\n-\tI-Chemical\nNAME\tI-Chemical\n,\tO\nthe\tO\nsystolic\tO\nblood\tO\npressure\tO\n(\tO\nSBP\tO\n)\tO\nincreased\tT-3\nby\tO\n36\tO\n%\tO\n.\tO\n\nWhen\tO\nactivating\tT-0\nthe\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nwith\tO\nits\tO\nsubstrate\tO\nATP\tO\n,\tO\nno\tO\nchanges\tO\nin\tO\nKm\tO\nand\tO\nVmax\tO\nvalues\tO\nwere\tO\nobserved\tO\nin\tO\nNO\tO\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nWhen\tO\nactivating\tT-0\nthe\tT-0\n(\tO\nNa\tO\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nwith\tO\nits\tO\nsubstrate\tO\nATP\tO\n,\tO\nno\tO\nchanges\tO\nin\tO\nKm\tO\nand\tO\nVmax\tO\nvalues\tO\nwere\tO\nobserved\tO\nin\tO\nNO\tO\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nWhen\tO\nactivating\tT-0\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nwith\tO\nits\tO\nsubstrate\tO\nATP\tB-Chemical\n,\tO\nno\tO\nchanges\tO\nin\tO\nKm\tO\nand\tO\nVmax\tO\nvalues\tO\nwere\tO\nobserved\tO\nin\tO\nNO\tO\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nWhen\tO\nactivating\tO\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nwith\tO\nits\tO\nsubstrate\tO\nATP\tO\n,\tO\nno\tO\nchanges\tO\nin\tO\nKm\tO\nand\tO\nVmax\tO\nvalues\tO\nwere\tO\nobserved\tT-1\nin\tT-1\nNO\tB-Chemical\n-\tT-0\ndeficient\tT-0\nrats\tO\n.\tO\n\nDuring\tO\nactivation\tT-2\nwith\tT-2\nNa\tB-Chemical\n+\tO\n,\tO\nthe\tO\nVmax\tO\nremained\tO\nunchanged\tO\n,\tO\nhowever\tO\nthe\tO\nK\tO\n(\tO\nNa\tO\n)\tO\nincreased\tO\nby\tO\n50\tO\n%\tO\n,\tO\nindicating\tT-1\na\tO\nprofound\tO\ndecrease\tO\nin\tO\nthe\tO\naffinity\tO\nof\tO\nthe\tO\nNa\tO\n+\tO\n-\tO\nbinding\tO\nsite\tO\nin\tO\nNO\tO\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nDuring\tT-0\nactivation\tT-0\nwith\tO\nNa\tO\n+\tO\n,\tO\nthe\tO\nVmax\tO\nremained\tO\nunchanged\tO\n,\tO\nhowever\tT-1\nthe\tT-1\nK\tB-Chemical\n(\tO\nNa\tO\n)\tO\nincreased\tT-2\nby\tT-2\n50\tO\n%\tO\n,\tO\nindicating\tO\na\tO\nprofound\tO\ndecrease\tO\nin\tO\nthe\tO\naffinity\tO\nof\tO\nthe\tO\nNa\tO\n+\tO\n-\tO\nbinding\tO\nsite\tO\nin\tO\nNO\tO\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nDuring\tO\nactivation\tO\nwith\tO\nNa\tO\n+\tO\n,\tO\nthe\tO\nVmax\tO\nremained\tO\nunchanged\tO\n,\tO\nhowever\tO\nthe\tO\nK\tT-0\n(\tO\nNa\tB-Chemical\n)\tO\nincreased\tT-1\nby\tT-1\n50\tO\n%\tO\n,\tO\nindicating\tO\na\tO\nprofound\tO\ndecrease\tO\nin\tO\nthe\tO\naffinity\tO\nof\tO\nthe\tO\nNa\tO\n+\tO\n-\tO\nbinding\tO\nsite\tO\nin\tO\nNO\tO\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nDuring\tO\nactivation\tO\nwith\tO\nNa\tO\n+\tO\n,\tO\nthe\tO\nVmax\tO\nremained\tO\nunchanged\tO\n,\tO\nhowever\tO\nthe\tO\nK\tO\n(\tO\nNa\tO\n)\tO\nincreased\tO\nby\tO\n50\tO\n%\tO\n,\tO\nindicating\tO\na\tO\nprofound\tO\ndecrease\tT-1\nin\tO\nthe\tO\naffinity\tT-0\nof\tT-0\nthe\tT-0\nNa\tB-Chemical\n+\tO\n-\tO\nbinding\tT-2\nsite\tO\nin\tO\nNO\tO\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nDuring\tO\nactivation\tO\nwith\tO\nNa\tO\n+\tO\n,\tO\nthe\tO\nVmax\tO\nremained\tO\nunchanged\tO\n,\tO\nhowever\tO\nthe\tO\nK\tO\n(\tO\nNa\tO\n)\tO\nincreased\tO\nby\tO\n50\tO\n%\tO\n,\tO\nindicating\tO\na\tT-1\nprofound\tT-1\ndecrease\tT-1\nin\tO\nthe\tO\naffinity\tO\nof\tO\nthe\tO\nNa\tO\n+\tO\n-\tO\nbinding\tT-0\nsite\tO\nin\tO\nNO\tB-Chemical\n-\tO\ndeficient\tO\nrats\tO\n.\tO\n\nAfter\tO\nrecovery\tT-0\nfrom\tT-0\nhypertension\tB-Disease\n,\tO\nthe\tO\nactivity\tO\nof\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nincreased\tO\n,\tO\ndue\tO\nto\tO\nhigher\tO\naffinity\tO\nof\tO\nthe\tO\nATP\tO\n-\tO\nbinding\tO\nsite\tO\n,\tO\nas\tO\nrevealed\tO\nfrom\tO\nthe\tO\nlowered\tO\nKm\tO\nvalue\tO\nfor\tO\nATP\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nfrom\tO\nhypertension\tO\n,\tO\nthe\tO\nactivity\tT-0\nof\tT-0\n(\tO\nNa\tB-Chemical\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nincreased\tO\n,\tO\ndue\tO\nto\tO\nhigher\tO\naffinity\tO\nof\tO\nthe\tO\nATP\tO\n-\tO\nbinding\tO\nsite\tO\n,\tO\nas\tO\nrevealed\tO\nfrom\tO\nthe\tO\nlowered\tO\nKm\tO\nvalue\tO\nfor\tO\nATP\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nfrom\tO\nhypertension\tO\n,\tO\nthe\tT-0\nactivity\tT-0\nof\tT-0\n(\tO\nNa\tO\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nincreased\tO\n,\tO\ndue\tO\nto\tO\nhigher\tO\naffinity\tO\nof\tO\nthe\tO\nATP\tO\n-\tO\nbinding\tO\nsite\tO\n,\tO\nas\tO\nrevealed\tO\nfrom\tO\nthe\tO\nlowered\tO\nKm\tO\nvalue\tO\nfor\tO\nATP\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nfrom\tO\nhypertension\tO\n,\tO\nthe\tO\nactivity\tO\nof\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nincreased\tO\n,\tO\ndue\tO\nto\tO\nhigher\tT-0\naffinity\tT-0\nof\tT-0\nthe\tO\nATP\tB-Chemical\n-\tO\nbinding\tT-1\nsite\tT-1\n,\tO\nas\tO\nrevealed\tO\nfrom\tO\nthe\tO\nlowered\tO\nKm\tO\nvalue\tO\nfor\tO\nATP\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nfrom\tO\nhypertension\tO\n,\tO\nthe\tO\nactivity\tO\nof\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nincreased\tO\n,\tO\ndue\tO\nto\tO\nhigher\tO\naffinity\tO\nof\tO\nthe\tO\nATP\tO\n-\tO\nbinding\tO\nsite\tO\n,\tO\nas\tT-0\nrevealed\tT-0\nfrom\tT-0\nthe\tO\nlowered\tO\nKm\tO\nvalue\tT-1\nfor\tT-1\nATP\tB-Chemical\n.\tO\n\nThe\tO\nK\tB-Chemical\n(\tO\nNa\tO\n)\tO\nvalue\tT-0\nfor\tO\nNa\tT-1\n+\tT-1\nreturned\tO\nto\tO\ncontrol\tO\nvalue\tO\n.\tO\n\nThe\tO\nK\tT-0\n(\tT-0\nNa\tT-0\n)\tT-0\nvalue\tT-2\nfor\tT-2\nNa\tB-Chemical\n+\tO\nreturned\tO\nto\tO\ncontrol\tT-1\nvalue\tT-1\n.\tO\n\nInhibition\tT-2\nof\tT-2\nNO\tB-Chemical\n-\tO\nsynthase\tT-0\ninduced\tT-3\na\tO\nreversible\tO\nhypertension\tO\naccompanied\tO\nby\tO\ndepressed\tO\nNa\tO\n+\tO\n-\tO\nextrusion\tT-1\nfrom\tO\ncardiac\tO\ncells\tO\nas\tO\na\tO\nconsequence\tO\nof\tO\ndeteriorated\tO\nNa\tO\n+\tO\n-\tO\nbinding\tO\nproperties\tO\nof\tO\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tO\n-\tO\nsynthase\tO\ninduced\tT-3\na\tT-3\nreversible\tT-0\nhypertension\tB-Disease\naccompanied\tO\nby\tO\ndepressed\tO\nNa\tO\n+\tO\n-\tO\nextrusion\tT-1\nfrom\tO\ncardiac\tO\ncells\tO\nas\tO\na\tO\nconsequence\tO\nof\tO\ndeteriorated\tT-2\nNa\tO\n+\tO\n-\tO\nbinding\tO\nproperties\tO\nof\tO\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tO\n-\tO\nsynthase\tO\ninduced\tT-0\na\tO\nreversible\tO\nhypertension\tO\naccompanied\tT-1\nby\tT-1\ndepressed\tB-Disease\nNa\tO\n+\tO\n-\tO\nextrusion\tO\nfrom\tO\ncardiac\tO\ncells\tO\nas\tO\na\tO\nconsequence\tO\nof\tO\ndeteriorated\tO\nNa\tO\n+\tO\n-\tO\nbinding\tO\nproperties\tO\nof\tO\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tO\n-\tO\nsynthase\tO\ninduced\tO\na\tO\nreversible\tO\nhypertension\tO\naccompanied\tO\nby\tO\ndepressed\tT-0\nNa\tB-Chemical\n+\tO\n-\tO\nextrusion\tT-1\nfrom\tO\ncardiac\tO\ncells\tO\nas\tO\na\tO\nconsequence\tT-2\nof\tO\ndeteriorated\tO\nNa\tO\n+\tO\n-\tO\nbinding\tO\nproperties\tO\nof\tO\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tO\n-\tO\nsynthase\tO\ninduced\tO\na\tO\nreversible\tO\nhypertension\tO\naccompanied\tO\nby\tO\ndepressed\tO\nNa\tO\n+\tO\n-\tO\nextrusion\tO\nfrom\tO\ncardiac\tO\ncells\tO\nas\tO\na\tO\nconsequence\tO\nof\tT-2\ndeteriorated\tT-2\nNa\tB-Chemical\n+\tT-1\n-\tT-1\nbinding\tT-1\nproperties\tT-1\nof\tO\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tO\n-\tO\nsynthase\tO\ninduced\tT-0\na\tO\nreversible\tO\nhypertension\tO\naccompanied\tO\nby\tO\ndepressed\tO\nNa\tO\n+\tO\n-\tO\nextrusion\tO\nfrom\tO\ncardiac\tO\ncells\tO\nas\tO\na\tO\nconsequence\tO\nof\tO\ndeteriorated\tO\nNa\tO\n+\tO\n-\tO\nbinding\tT-1\nproperties\tT-1\nof\tT-1\nthe\tT-1\n(\tO\nNa\tB-Chemical\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\n.\tO\n\nInhibition\tO\nof\tO\nNO\tO\n-\tO\nsynthase\tO\ninduced\tT-0\na\tO\nreversible\tO\nhypertension\tO\naccompanied\tO\nby\tO\ndepressed\tO\nNa\tO\n+\tO\n-\tO\nextrusion\tO\nfrom\tO\ncardiac\tO\ncells\tO\nas\tO\na\tO\nconsequence\tO\nof\tO\ndeteriorated\tO\nNa\tO\n+\tO\n-\tO\nbinding\tT-1\nproperties\tT-1\nof\tO\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\n.\tO\n\nAfter\tO\nrecovery\tT-0\nof\tO\nblood\tO\npressure\tO\nto\tO\ncontrol\tO\nvalues\tO\n,\tO\nthe\tO\nextrusion\tO\nof\tO\nNa\tB-Chemical\n+\tO\nfrom\tO\ncardiac\tO\ncells\tO\nwas\tO\nnormalized\tT-1\n,\tO\nas\tO\nrevealed\tO\nby\tO\nrestoration\tT-2\nof\tO\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nactivity\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nof\tO\nblood\tO\npressure\tO\nto\tO\ncontrol\tO\nvalues\tO\n,\tO\nthe\tO\nextrusion\tO\nof\tO\nNa\tO\n+\tO\nfrom\tO\ncardiac\tO\ncells\tO\nwas\tO\nnormalized\tO\n,\tO\nas\tO\nrevealed\tO\nby\tO\nrestoration\tT-0\nof\tT-0\nthe\tO\n(\tO\nNa\tB-Chemical\n,\tO\nK\tO\n)\tO\n-\tO\nATPase\tO\nactivity\tO\n.\tO\n\nAfter\tO\nrecovery\tO\nof\tO\nblood\tO\npressure\tO\nto\tO\ncontrol\tO\nvalues\tO\n,\tO\nthe\tO\nextrusion\tO\nof\tO\nNa\tO\n+\tO\nfrom\tO\ncardiac\tO\ncells\tO\nwas\tO\nnormalized\tO\n,\tO\nas\tO\nrevealed\tT-0\nby\tT-0\nrestoration\tO\nof\tO\nthe\tO\n(\tO\nNa\tO\n,\tO\nK\tB-Chemical\n)\tO\n-\tO\nATPase\tO\nactivity\tO\n.\tO\n\nEffects\tT-1\nof\tT-1\nlong\tO\n-\tO\nterm\tO\npretreatment\tT-2\nwith\tT-2\nisoproterenol\tB-Chemical\non\tO\nbromocriptine\tO\n-\tO\ninduced\tT-0\ntachycardia\tO\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nEffects\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\npretreatment\tO\nwith\tO\nisoproterenol\tO\non\tO\nbromocriptine\tB-Chemical\n-\tT-1\ninduced\tT-1\ntachycardia\tO\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nEffects\tO\nof\tO\nlong\tO\n-\tO\nterm\tO\npretreatment\tO\nwith\tO\nisoproterenol\tT-0\non\tO\nbromocriptine\tT-1\n-\tO\ninduced\tT-3\ntachycardia\tB-Disease\nin\tO\nconscious\tO\nrats\tT-2\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nshown\tO\nthat\tO\nbromocriptine\tB-Chemical\n-\tT-3\ninduced\tT-3\ntachycardia\tO\n,\tO\nwhich\tO\npersisted\tO\nafter\tO\nadrenalectomy\tO\n,\tO\nis\tO\n(\tO\ni\tO\n)\tO\nmediated\tT-1\nby\tT-1\ncentral\tO\ndopamine\tO\nD2\tO\nreceptor\tO\nactivation\tT-2\nand\tO\n(\tO\nii\tO\n)\tO\nreduced\tO\nby\tO\n5\tO\n-\tO\nday\tO\nisoproterenol\tO\npretreatment\tO\n,\tO\nsupporting\tO\ntherefore\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthis\tO\neffect\tO\nis\tO\ndependent\tO\non\tO\nsympathetic\tO\noutflow\tO\nto\tO\nthe\tO\nheart\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nshown\tO\nthat\tO\nbromocriptine\tO\n-\tO\ninduced\tT-0\ntachycardia\tB-Disease\n,\tO\nwhich\tO\npersisted\tO\nafter\tO\nadrenalectomy\tO\n,\tO\nis\tO\n(\tO\ni\tO\n)\tO\nmediated\tO\nby\tO\ncentral\tO\ndopamine\tO\nD2\tO\nreceptor\tO\nactivation\tO\nand\tO\n(\tO\nii\tO\n)\tO\nreduced\tO\nby\tO\n5\tO\n-\tO\nday\tO\nisoproterenol\tO\npretreatment\tO\n,\tO\nsupporting\tO\ntherefore\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthis\tO\neffect\tO\nis\tO\ndependent\tO\non\tO\nsympathetic\tO\noutflow\tO\nto\tO\nthe\tO\nheart\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nshown\tO\nthat\tO\nbromocriptine\tO\n-\tO\ninduced\tO\ntachycardia\tO\n,\tO\nwhich\tO\npersisted\tO\nafter\tO\nadrenalectomy\tO\n,\tO\nis\tO\n(\tO\ni\tO\n)\tO\nmediated\tT-0\nby\tT-2\ncentral\tT-2\ndopamine\tB-Chemical\nD2\tT-1\nreceptor\tT-1\nactivation\tO\nand\tO\n(\tO\nii\tO\n)\tO\nreduced\tO\nby\tO\n5\tO\n-\tO\nday\tO\nisoproterenol\tO\npretreatment\tO\n,\tO\nsupporting\tO\ntherefore\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthis\tO\neffect\tO\nis\tO\ndependent\tO\non\tO\nsympathetic\tO\noutflow\tO\nto\tO\nthe\tO\nheart\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nshown\tO\nthat\tO\nbromocriptine\tO\n-\tO\ninduced\tO\ntachycardia\tO\n,\tO\nwhich\tO\npersisted\tO\nafter\tO\nadrenalectomy\tO\n,\tO\nis\tO\n(\tO\ni\tO\n)\tO\nmediated\tO\nby\tO\ncentral\tO\ndopamine\tO\nD2\tO\nreceptor\tO\nactivation\tO\nand\tO\n(\tO\nii\tO\n)\tO\nreduced\tT-0\nby\tT-0\n5\tO\n-\tO\nday\tO\nisoproterenol\tB-Chemical\npretreatment\tT-1\n,\tO\nsupporting\tO\ntherefore\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthis\tO\neffect\tO\nis\tO\ndependent\tO\non\tO\nsympathetic\tO\noutflow\tO\nto\tO\nthe\tO\nheart\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nconducted\tO\nto\tO\nexamine\tO\nwhether\tO\nprolonged\tO\npretreatment\tT-0\nwith\tT-0\nisoproterenol\tB-Chemical\ncould\tT-1\nabolish\tT-1\nbromocriptine\tO\n-\tO\ninduced\tO\ntachycardia\tO\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nconducted\tO\nto\tO\nexamine\tO\nwhether\tO\nprolonged\tO\npretreatment\tO\nwith\tO\nisoproterenol\tO\ncould\tO\nabolish\tO\nbromocriptine\tB-Chemical\n-\tT-0\ninduced\tT-1\ntachycardia\tT-1\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nThis\tO\nstudy\tO\nwas\tO\nconducted\tO\nto\tO\nexamine\tO\nwhether\tO\nprolonged\tO\npretreatment\tO\nwith\tO\nisoproterenol\tO\ncould\tO\nabolish\tO\nbromocriptine\tO\n-\tO\ninduced\tT-0\ntachycardia\tB-Disease\nin\tO\nconscious\tO\nrats\tO\n.\tO\n\nIsoproterenol\tB-Chemical\npretreatment\tT-0\nfor\tO\n15\tO\ndays\tO\ncaused\tO\ncardiac\tO\nhypertrophy\tO\nwithout\tO\naffecting\tO\nbaseline\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\n.\tO\n\nIsoproterenol\tO\npretreatment\tT-1\nfor\tO\n15\tO\ndays\tO\ncaused\tT-0\ncardiac\tB-Disease\nhypertrophy\tI-Disease\nwithout\tO\naffecting\tO\nbaseline\tO\nblood\tO\npressure\tO\nand\tO\nheart\tO\nrate\tO\n.\tO\n\nIn\tO\ncontrol\tO\nrats\tO\n,\tO\nintravenous\tT-0\nbromocriptine\tB-Chemical\n(\tO\n150\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\ninduced\tT-1\nsignificant\tO\nhypotension\tO\nand\tO\ntachycardia\tO\n.\tO\n\nIn\tO\ncontrol\tO\nrats\tO\n,\tO\nintravenous\tO\nbromocriptine\tO\n(\tO\n150\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\ninduced\tT-0\nsignificant\tT-0\nhypotension\tB-Disease\nand\tO\ntachycardia\tO\n.\tO\n\nIn\tO\ncontrol\tO\nrats\tO\n,\tO\nintravenous\tO\nbromocriptine\tO\n(\tO\n150\tO\nmicrog\tO\n/\tO\nkg\tO\n)\tO\ninduced\tO\nsignificant\tO\nhypotension\tO\nand\tT-0\ntachycardia\tB-Disease\n.\tO\n\nBromocriptine\tB-Chemical\n-\tO\ninduced\tT-0\nhypotension\tO\nwas\tT-1\nunaffected\tT-1\nby\tO\nisoproterenol\tO\npretreatment\tO\n,\tO\nwhile\tO\ntachycardia\tO\nwas\tO\nreversed\tO\nto\tO\nsignificant\tO\nbradycardia\tO\n,\tO\nan\tO\neffect\tO\nthat\tO\nwas\tO\npartly\tO\nreduced\tO\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\ndomperidone\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nBromocriptine\tO\n-\tO\ninduced\tT-2\nhypotension\tB-Disease\nwas\tO\nunaffected\tT-3\nby\tT-3\nisoproterenol\tO\npretreatment\tO\n,\tO\nwhile\tO\ntachycardia\tT-0\nwas\tO\nreversed\tO\nto\tO\nsignificant\tO\nbradycardia\tT-1\n,\tO\nan\tO\neffect\tO\nthat\tO\nwas\tO\npartly\tO\nreduced\tO\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\ndomperidone\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nBromocriptine\tO\n-\tO\ninduced\tO\nhypotension\tO\nwas\tO\nunaffected\tT-0\nby\tT-0\nisoproterenol\tB-Chemical\npretreatment\tO\n,\tO\nwhile\tO\ntachycardia\tO\nwas\tO\nreversed\tO\nto\tO\nsignificant\tO\nbradycardia\tO\n,\tO\nan\tO\neffect\tO\nthat\tO\nwas\tO\npartly\tO\nreduced\tO\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\ndomperidone\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nBromocriptine\tO\n-\tO\ninduced\tT-2\nhypotension\tO\nwas\tO\nunaffected\tO\nby\tO\nisoproterenol\tO\npretreatment\tO\n,\tO\nwhile\tO\ntachycardia\tB-Disease\nwas\tT-1\nreversed\tT-1\nto\tT-1\nsignificant\tT-1\nbradycardia\tT-1\n,\tO\nan\tO\neffect\tO\nthat\tO\nwas\tO\npartly\tT-3\nreduced\tT-3\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\ndomperidone\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nBromocriptine\tO\n-\tO\ninduced\tO\nhypotension\tO\nwas\tO\nunaffected\tO\nby\tO\nisoproterenol\tO\npretreatment\tO\n,\tO\nwhile\tO\ntachycardia\tO\nwas\tO\nreversed\tT-2\nto\tT-0\nsignificant\tT-0\nbradycardia\tB-Disease\n,\tO\nan\tT-1\neffect\tT-1\nthat\tT-1\nwas\tO\npartly\tO\nreduced\tT-3\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\ndomperidone\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nBromocriptine\tO\n-\tO\ninduced\tO\nhypotension\tO\nwas\tO\nunaffected\tO\nby\tO\nisoproterenol\tO\npretreatment\tO\n,\tO\nwhile\tO\ntachycardia\tO\nwas\tO\nreversed\tO\nto\tO\nsignificant\tO\nbradycardia\tO\n,\tO\nan\tO\neffect\tT-0\nthat\tO\nwas\tO\npartly\tO\nreduced\tT-1\nby\tO\ni\tO\n.\tO\nv\tO\n.\tO\ndomperidone\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\n.\tO\n\nNeither\tO\ncardiac\tO\nvagal\tO\nnor\tO\nsympathetic\tO\ntone\tO\nwas\tT-3\naltered\tT-3\nby\tT-2\nisoproterenol\tB-Chemical\npretreatment\tT-1\n.\tO\n\nIn\tO\nisolated\tO\nperfused\tO\nheart\tO\npreparations\tO\nfrom\tT-2\nisoproterenol\tB-Chemical\n-\tO\npretreated\tO\nrats\tO\n,\tO\nthe\tO\nisoproterenol\tO\n-\tO\ninduced\tO\nmaximal\tO\nincrease\tT-1\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nsignificantly\tO\nreduced\tO\n,\tO\ncompared\tO\nwith\tO\nsaline\tO\n-\tO\npretreated\tO\nrats\tO\n(\tO\nthe\tO\nEC50\tO\nof\tO\nthe\tO\nisoproterenol\tO\n-\tO\ninduced\tT-0\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nenhanced\tO\napproximately\tO\n22\tO\n-\tO\nfold\tO\n)\tO\n.\tO\n\nIn\tO\nisolated\tO\nperfused\tO\nheart\tO\npreparations\tO\nfrom\tO\nisoproterenol\tO\n-\tO\npretreated\tO\nrats\tO\n,\tO\nthe\tT-0\nisoproterenol\tB-Chemical\n-\tO\ninduced\tT-1\nmaximal\tO\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nsignificantly\tO\nreduced\tO\n,\tO\ncompared\tO\nwith\tO\nsaline\tO\n-\tO\npretreated\tO\nrats\tO\n(\tO\nthe\tO\nEC50\tO\nof\tO\nthe\tO\nisoproterenol\tO\n-\tO\ninduced\tO\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nenhanced\tO\napproximately\tO\n22\tO\n-\tO\nfold\tO\n)\tO\n.\tO\n\nIn\tO\nisolated\tO\nperfused\tO\nheart\tO\npreparations\tO\nfrom\tO\nisoproterenol\tO\n-\tO\npretreated\tO\nrats\tO\n,\tO\nthe\tO\nisoproterenol\tO\n-\tO\ninduced\tO\nmaximal\tO\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nsignificantly\tO\nreduced\tO\n,\tO\ncompared\tO\nwith\tO\nsaline\tO\n-\tO\npretreated\tO\nrats\tO\n(\tO\nthe\tO\nEC50\tO\nof\tT-0\nthe\tT-0\nisoproterenol\tB-Chemical\n-\tO\ninduced\tT-1\nincrease\tO\nin\tO\nleft\tO\nventricular\tO\nsystolic\tO\npressure\tO\nwas\tO\nenhanced\tO\napproximately\tO\n22\tO\n-\tO\nfold\tO\n)\tO\n.\tO\n\nThese\tO\nresults\tT-2\nshow\tT-2\nthat\tO\n15\tO\n-\tO\nday\tO\nisoproterenol\tB-Chemical\npretreatment\tO\nnot\tO\nonly\tO\nabolished\tT-0\nbut\tO\nreversed\tT-1\nbromocriptine\tO\n-\tO\ninduced\tO\ntachycardia\tO\nto\tO\nbradycardia\tO\n,\tO\nan\tT-3\neffect\tT-3\nthat\tO\nis\tO\nmainly\tO\nrelated\tO\nto\tO\nfurther\tO\ncardiac\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\ndesensitization\tO\nrather\tO\nthan\tO\nto\tO\nimpairment\tO\nof\tO\nautonomic\tO\nregulation\tO\nof\tO\nthe\tO\nheart\tO\n.\tO\n\nThese\tO\nresults\tO\nshow\tO\nthat\tO\n15\tO\n-\tO\nday\tO\nisoproterenol\tO\npretreatment\tO\nnot\tO\nonly\tO\nabolished\tO\nbut\tO\nreversed\tT-0\nbromocriptine\tB-Chemical\n-\tO\ninduced\tT-1\ntachycardia\tO\nto\tO\nbradycardia\tO\n,\tO\nan\tO\neffect\tO\nthat\tO\nis\tO\nmainly\tO\nrelated\tO\nto\tO\nfurther\tO\ncardiac\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\ndesensitization\tO\nrather\tO\nthan\tO\nto\tO\nimpairment\tO\nof\tO\nautonomic\tO\nregulation\tO\nof\tO\nthe\tO\nheart\tO\n.\tO\n\nThese\tO\nresults\tO\nshow\tO\nthat\tO\n15\tO\n-\tO\nday\tO\nisoproterenol\tO\npretreatment\tO\nnot\tO\nonly\tO\nabolished\tO\nbut\tO\nreversed\tO\nbromocriptine\tO\n-\tT-1\ninduced\tT-1\ntachycardia\tB-Disease\nto\tT-2\nbradycardia\tT-2\n,\tO\nan\tO\neffect\tO\nthat\tO\nis\tO\nmainly\tO\nrelated\tO\nto\tO\nfurther\tO\ncardiac\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\ndesensitization\tO\nrather\tO\nthan\tO\nto\tO\nimpairment\tO\nof\tO\nautonomic\tO\nregulation\tO\nof\tO\nthe\tO\nheart\tO\n.\tO\n\nThese\tO\nresults\tT-2\nshow\tT-2\nthat\tT-2\n15\tO\n-\tO\nday\tO\nisoproterenol\tO\npretreatment\tO\nnot\tO\nonly\tO\nabolished\tO\nbut\tO\nreversed\tO\nbromocriptine\tO\n-\tO\ninduced\tT-0\ntachycardia\tO\nto\tO\nbradycardia\tB-Disease\n,\tO\nan\tO\neffect\tO\nthat\tO\nis\tO\nmainly\tO\nrelated\tT-1\nto\tT-1\nfurther\tO\ncardiac\tO\nbeta\tO\n-\tO\nadrenoceptor\tO\ndesensitization\tO\nrather\tO\nthan\tO\nto\tO\nimpairment\tO\nof\tO\nautonomic\tO\nregulation\tO\nof\tO\nthe\tO\nheart\tO\n.\tO\n\nThey\tO\nsuggest\tO\nthat\tO\n,\tO\nin\tO\nnormal\tO\nconscious\tO\nrats\tO\n,\tO\nthe\tO\ncentral\tT-0\ntachycardia\tB-Disease\nof\tT-1\nbromocriptine\tT-1\nappears\tO\nto\tO\npredominate\tO\nand\tO\nto\tO\nmask\tO\nthe\tO\nbradycardia\tO\nof\tO\nthis\tO\nagonist\tO\nat\tO\nperipheral\tO\ndopamine\tO\nD2\tO\nreceptors\tO\n.\tO\n\nThey\tO\nsuggest\tO\nthat\tO\n,\tO\nin\tO\nnormal\tO\nconscious\tO\nrats\tO\n,\tO\nthe\tO\ncentral\tO\ntachycardia\tO\nof\tO\nbromocriptine\tB-Chemical\nappears\tT-2\nto\tT-2\npredominate\tT-0\nand\tO\nto\tO\nmask\tT-1\nthe\tO\nbradycardia\tO\nof\tO\nthis\tO\nagonist\tO\nat\tO\nperipheral\tO\ndopamine\tO\nD2\tO\nreceptors\tO\n.\tO\n\nThey\tO\nsuggest\tO\nthat\tO\n,\tO\nin\tO\nnormal\tO\nconscious\tO\nrats\tO\n,\tO\nthe\tO\ncentral\tO\ntachycardia\tO\nof\tO\nbromocriptine\tO\nappears\tT-1\nto\tO\npredominate\tO\nand\tO\nto\tT-0\nmask\tT-0\nthe\tT-0\nbradycardia\tB-Disease\nof\tO\nthis\tO\nagonist\tO\nat\tO\nperipheral\tO\ndopamine\tO\nD2\tO\nreceptors\tO\n.\tO\n\nThey\tO\nsuggest\tO\nthat\tO\n,\tO\nin\tO\nnormal\tO\nconscious\tO\nrats\tO\n,\tO\nthe\tO\ncentral\tO\ntachycardia\tO\nof\tO\nbromocriptine\tO\nappears\tO\nto\tO\npredominate\tO\nand\tO\nto\tO\nmask\tO\nthe\tO\nbradycardia\tO\nof\tT-2\nthis\tT-2\nagonist\tT-2\nat\tT-0\nperipheral\tT-0\ndopamine\tB-Chemical\nD2\tO\nreceptors\tT-1\n.\tO\n\nA\tO\ndevelopmental\tO\nanalysis\tO\nof\tO\nclonidine\tB-Chemical\n'\tT-0\ns\tT-0\neffects\tT-0\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nin\tO\ninfant\tO\nrats\tO\n.\tO\n\nUnder\tO\ncontrolled\tO\nconditions\tO\n,\tO\ninfant\tO\nrats\tO\nemit\tT-0\nultrasonic\tO\nvocalizations\tO\nduring\tO\nextreme\tO\ncold\tO\nexposure\tO\nand\tO\nafter\tO\nadministration\tT-1\nof\tO\nthe\tO\nalpha\tO\n(\tO\n2\tO\n)\tO\nadrenoceptor\tO\nagonist\tO\n,\tO\nclonidine\tB-Chemical\n.\tO\n\nPrevious\tO\ninvestigations\tO\nhave\tO\ndetermined\tO\nthat\tO\n,\tO\nin\tT-0\nresponse\tT-0\nto\tT-0\nclonidine\tB-Chemical\n,\tO\nultrasound\tO\nproduction\tO\nincreases\tO\nthrough\tO\nthe\tO\n2nd\tO\n-\tO\nweek\tO\npostpartum\tO\nand\tO\ndecreases\tO\nthereafter\tO\n.\tO\n\nGiven\tO\nthat\tO\nsympathetic\tO\nneural\tO\ndominance\tO\nexhibits\tO\na\tO\nsimilar\tO\ndevelopmental\tO\npattern\tO\n,\tO\nand\tO\ngiven\tO\nthat\tO\nclonidine\tB-Chemical\ninduces\tT-1\nsympathetic\tO\nwithdrawal\tO\nand\tO\nbradycardia\tO\n,\tO\nwe\tO\nhypothesized\tO\nthat\tO\nclonidine\tO\n'\tO\ns\tO\ndevelopmental\tO\neffects\tT-2\non\tT-2\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nwould\tO\nmirror\tO\neach\tO\nother\tO\n.\tO\n\nGiven\tO\nthat\tO\nsympathetic\tO\nneural\tO\ndominance\tO\nexhibits\tO\na\tO\nsimilar\tO\ndevelopmental\tO\npattern\tO\n,\tO\nand\tO\ngiven\tO\nthat\tO\nclonidine\tO\ninduces\tT-1\nsympathetic\tO\nwithdrawal\tO\nand\tO\nbradycardia\tB-Disease\n,\tO\nwe\tO\nhypothesized\tO\nthat\tO\nclonidine\tO\n'\tO\ns\tO\ndevelopmental\tO\neffects\tO\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nwould\tO\nmirror\tO\neach\tO\nother\tO\n.\tO\n\nGiven\tO\nthat\tO\nsympathetic\tO\nneural\tO\ndominance\tO\nexhibits\tO\na\tO\nsimilar\tO\ndevelopmental\tO\npattern\tO\n,\tO\nand\tO\ngiven\tO\nthat\tO\nclonidine\tO\ninduces\tT-0\nsympathetic\tO\nwithdrawal\tO\nand\tO\nbradycardia\tO\n,\tO\nwe\tO\nhypothesized\tT-1\nthat\tO\nclonidine\tB-Chemical\n'\tO\ns\tO\ndevelopmental\tO\neffects\tO\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nwould\tO\nmirror\tO\neach\tO\nother\tO\n.\tO\n\nTherefore\tO\n,\tO\nin\tO\nthe\tO\npresent\tO\nexperiment\tO\n,\tO\nthe\tO\neffects\tT-0\nof\tT-0\nclonidine\tB-Chemical\nadministration\tT-1\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\non\tO\ncardiac\tO\nrate\tO\nand\tO\nultrasound\tO\nproduction\tO\nwere\tO\nexamined\tO\nin\tO\n2\tO\n-\tO\n,\tO\n8\tO\n-\tO\n,\tO\n15\tO\n-\tO\n,\tO\nand\tO\n20\tO\n-\tO\nday\tO\n-\tO\nold\tO\nrats\tO\n.\tO\n\nAge\tO\n-\tO\nrelated\tO\nchanges\tO\nin\tO\nultrasound\tO\nproduction\tO\ncorresponded\tO\nwith\tO\nchanges\tO\nin\tO\ncardiovascular\tO\nvariables\tO\n,\tO\nincluding\tO\nbaseline\tO\ncardiac\tO\nrate\tO\nand\tT-0\nclonidine\tB-Chemical\n-\tO\ninduced\tT-1\nbradycardia\tO\n.\tO\n\nAge\tO\n-\tO\nrelated\tO\nchanges\tO\nin\tO\nultrasound\tO\nproduction\tO\ncorresponded\tO\nwith\tO\nchanges\tO\nin\tO\ncardiovascular\tO\nvariables\tO\n,\tO\nincluding\tO\nbaseline\tO\ncardiac\tO\nrate\tO\nand\tO\nclonidine\tO\n-\tT-1\ninduced\tT-1\nbradycardia\tB-Disease\n.\tO\n\nThis\tO\nexperiment\tO\nis\tO\ndiscussed\tO\nwith\tO\nregard\tO\nto\tO\nthe\tO\nhypothesis\tO\nthat\tO\nultrasound\tO\nproduction\tO\nis\tO\nthe\tO\nacoustic\tO\nby\tO\n-\tO\nproduct\tO\nof\tO\na\tO\nphysiological\tO\nmaneuver\tO\nthat\tO\ncompensates\tT-0\nfor\tT-0\nclonidine\tB-Chemical\n'\tO\ns\tO\ndetrimental\tO\neffects\tT-1\non\tO\ncardiovascular\tO\nfunction\tO\n.\tO\n\nRecurrent\tO\nuse\tT-1\nof\tT-1\nnewer\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n.\tT-0\n\nRecurrent\tO\nuse\tO\nof\tO\nnewer\tO\noral\tO\ncontraceptives\tO\nand\tO\nthe\tO\nrisk\tT-1\nof\tT-1\nvenous\tB-Disease\nthromboembolism\tI-Disease\n.\tO\n\nThe\tO\nepidemiological\tO\nstudies\tO\nthat\tO\nassessed\tO\nthe\tO\nrisk\tT-0\nof\tT-0\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tO\n)\tO\nassociated\tO\nwith\tO\nnewer\tO\noral\tO\ncontraceptives\tO\n(\tO\nOC\tO\n)\tO\ndid\tO\nnot\tO\ndistinguish\tO\nbetween\tO\npatterns\tO\nof\tO\nOC\tO\nuse\tO\n,\tO\nnamely\tO\nfirst\tO\n-\tO\ntime\tO\nusers\tO\n,\tO\nrepeaters\tO\nand\tO\nswitchers\tO\n.\tO\n\nThe\tO\nepidemiological\tO\nstudies\tO\nthat\tO\nassessed\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tB-Disease\n)\tO\nassociated\tT-0\nwith\tT-0\nnewer\tO\noral\tO\ncontraceptives\tO\n(\tO\nOC\tO\n)\tO\ndid\tO\nnot\tO\ndistinguish\tO\nbetween\tO\npatterns\tO\nof\tO\nOC\tO\nuse\tO\n,\tO\nnamely\tO\nfirst\tO\n-\tO\ntime\tO\nusers\tO\n,\tO\nrepeaters\tO\nand\tO\nswitchers\tO\n.\tO\n\nThe\tO\nepidemiological\tO\nstudies\tO\nthat\tO\nassessed\tT-0\nthe\tT-0\nrisk\tT-0\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tO\n)\tO\nassociated\tO\nwith\tO\nnewer\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n(\tO\nOC\tO\n)\tO\ndid\tO\nnot\tO\ndistinguish\tO\nbetween\tO\npatterns\tO\nof\tO\nOC\tO\nuse\tO\n,\tO\nnamely\tO\nfirst\tO\n-\tO\ntime\tO\nusers\tO\n,\tO\nrepeaters\tO\nand\tO\nswitchers\tO\n.\tO\n\nThe\tO\nepidemiological\tO\nstudies\tO\nthat\tO\nassessed\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tO\n)\tO\nassociated\tT-0\nwith\tT-0\nnewer\tO\noral\tO\ncontraceptives\tO\n(\tO\nOC\tB-Chemical\n)\tO\ndid\tO\nnot\tO\ndistinguish\tO\nbetween\tO\npatterns\tO\nof\tO\nOC\tO\nuse\tO\n,\tO\nnamely\tO\nfirst\tO\n-\tO\ntime\tO\nusers\tO\n,\tO\nrepeaters\tO\nand\tO\nswitchers\tO\n.\tO\n\nThe\tO\nepidemiological\tO\nstudies\tO\nthat\tO\nassessed\tO\nthe\tO\nrisk\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tO\n)\tO\nassociated\tO\nwith\tO\nnewer\tO\noral\tO\ncontraceptives\tO\n(\tO\nOC\tO\n)\tO\ndid\tO\nnot\tO\ndistinguish\tO\nbetween\tO\npatterns\tT-0\nof\tT-0\nOC\tB-Chemical\nuse\tT-1\n,\tO\nnamely\tO\nfirst\tO\n-\tO\ntime\tO\nusers\tO\n,\tO\nrepeaters\tO\nand\tO\nswitchers\tO\n.\tO\n\nData\tO\nfrom\tO\na\tO\nTransnational\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nwere\tO\nused\tO\nto\tO\nassess\tO\nthe\tO\nrisk\tT-0\nof\tT-0\nVTE\tB-Disease\nfor\tO\nthe\tO\nlatter\tO\npatterns\tO\nof\tO\nuse\tO\n,\tO\nwhile\tO\naccounting\tO\nfor\tO\nduration\tO\nof\tO\nuse\tO\n.\tO\n\nOver\tO\nthe\tO\nperiod\tO\n1993\tO\n-\tO\n1996\tO\n,\tO\n551\tO\ncases\tT-2\nof\tT-2\nVTE\tB-Disease\nwere\tT-0\nidentified\tT-1\nin\tO\nGermany\tO\nand\tO\nthe\tO\nUK\tO\nalong\tO\nwith\tO\n2066\tO\ncontrols\tO\n.\tO\n\nThe\tO\nadjusted\tT-1\nrate\tT-0\nratio\tT-0\nof\tT-0\nVTE\tB-Disease\nfor\tO\nrepeat\tO\nusers\tO\nof\tO\nthird\tO\ngeneration\tO\nOC\tO\nwas\tO\n0\tO\n.\tO\n6\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n3\tO\n-\tO\n1\tO\n.\tO\n2\tO\n)\tO\nrelative\tO\nto\tO\nrepeat\tO\nusers\tO\nof\tO\nsecond\tO\ngeneration\tO\npills\tO\n,\tO\nwhereas\tO\nit\tO\nwas\tO\n1\tO\n.\tO\n3\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n7\tO\n-\tO\n2\tO\n.\tO\n4\tO\n)\tO\nfor\tO\nswitchers\tO\nfrom\tO\nsecond\tO\nto\tO\nthird\tO\ngeneration\tO\npills\tO\nrelative\tO\nto\tO\nswitchers\tO\nfrom\tO\nthird\tO\nto\tO\nsecond\tO\ngeneration\tO\npills\tO\n.\tO\n\nThe\tO\nadjusted\tO\nrate\tO\nratio\tO\nof\tO\nVTE\tO\nfor\tO\nrepeat\tO\nusers\tT-0\nof\tT-0\nthird\tO\ngeneration\tO\nOC\tB-Chemical\nwas\tT-1\n0\tO\n.\tO\n6\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n3\tO\n-\tO\n1\tO\n.\tO\n2\tO\n)\tO\nrelative\tO\nto\tO\nrepeat\tO\nusers\tO\nof\tO\nsecond\tO\ngeneration\tO\npills\tO\n,\tO\nwhereas\tO\nit\tO\nwas\tO\n1\tO\n.\tO\n3\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n:\tO\n0\tO\n.\tO\n7\tO\n-\tO\n2\tO\n.\tO\n4\tO\n)\tO\nfor\tO\nswitchers\tO\nfrom\tO\nsecond\tO\nto\tO\nthird\tO\ngeneration\tO\npills\tO\nrelative\tO\nto\tO\nswitchers\tO\nfrom\tO\nthird\tO\nto\tO\nsecond\tO\ngeneration\tO\npills\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nsecond\tO\nand\tO\nthird\tO\ngeneration\tO\nagents\tO\nare\tO\nassociated\tO\nwith\tO\nequivalent\tO\nrisks\tT-1\nof\tT-1\nVTE\tB-Disease\nwhen\tO\nthe\tO\nsame\tO\nagent\tO\nis\tO\nused\tT-0\nrepeatedly\tO\nafter\tO\ninterruption\tO\nperiods\tO\nor\tO\nwhen\tO\nusers\tO\nare\tO\nswitched\tO\nbetween\tO\nthe\tO\ntwo\tO\ngenerations\tO\nof\tO\npills\tO\n.\tO\n\nThese\tO\nanalyses\tO\nsuggest\tO\nthat\tO\nthe\tO\nhigher\tO\nrisk\tO\nobserved\tT-1\nfor\tT-1\nthe\tO\nnewer\tO\nOC\tB-Chemical\nin\tO\nother\tO\nstudies\tO\nmay\tO\nbe\tO\nthe\tO\nresult\tO\nof\tO\ninadequate\tT-0\ncomparisons\tT-0\nof\tO\npill\tO\nusers\tO\nwith\tO\ndifferent\tO\npatterns\tO\nof\tO\npill\tO\nuse\tO\n.\tO\n\nDifferential\tO\neffects\tO\nof\tO\nsystemically\tT-1\nadministered\tT-1\nketamine\tB-Chemical\nand\tO\nlidocaine\tO\non\tO\ndynamic\tO\nand\tO\nstatic\tO\nhyperalgesia\tO\ninduced\tT-0\nby\tO\nintradermal\tO\ncapsaicin\tO\nin\tO\nhumans\tO\n.\tO\n\nDifferential\tO\neffects\tT-1\nof\tT-1\nsystemically\tO\nadministered\tO\nketamine\tO\nand\tO\nlidocaine\tB-Chemical\non\tO\ndynamic\tO\nand\tO\nstatic\tO\nhyperalgesia\tO\ninduced\tT-2\nby\tT-2\nintradermal\tO\ncapsaicin\tO\nin\tO\nhumans\tO\n.\tO\n\nDifferential\tO\neffects\tO\nof\tO\nsystemically\tO\nadministered\tT-2\nketamine\tO\nand\tO\nlidocaine\tO\non\tO\ndynamic\tT-1\nand\tT-1\nstatic\tT-1\nhyperalgesia\tB-Disease\ninduced\tT-3\nby\tO\nintradermal\tO\ncapsaicin\tO\nin\tT-0\nhumans\tT-0\n.\tO\n\nDifferential\tO\neffects\tT-0\nof\tT-0\nsystemically\tO\nadministered\tO\nketamine\tO\nand\tO\nlidocaine\tO\non\tO\ndynamic\tO\nand\tO\nstatic\tO\nhyperalgesia\tO\ninduced\tT-1\nby\tT-1\nintradermal\tO\ncapsaicin\tB-Chemical\nin\tT-2\nhumans\tT-2\n.\tO\n\nWe\tO\nhave\tO\nexamined\tO\nthe\tO\neffect\tO\nof\tO\nsystemic\tO\nadministration\tT-1\nof\tO\nketamine\tB-Chemical\nand\tO\nlidocaine\tO\non\tO\nbrush\tO\n-\tO\nevoked\tO\n(\tO\ndynamic\tO\n)\tO\npain\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\n(\tO\nstatic\tO\n)\tO\nhyperalgesia\tT-2\ninduced\tT-0\nby\tT-0\ncapsaicin\tO\n.\tO\n\nWe\tO\nhave\tO\nexamined\tO\nthe\tO\neffect\tO\nof\tO\nsystemic\tO\nadministration\tO\nof\tO\nketamine\tT-2\nand\tT-2\nlidocaine\tB-Chemical\non\tT-1\nbrush\tT-1\n-\tO\nevoked\tO\n(\tO\ndynamic\tO\n)\tO\npain\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\n(\tO\nstatic\tO\n)\tO\nhyperalgesia\tO\ninduced\tO\nby\tO\ncapsaicin\tO\n.\tO\n\nWe\tO\nhave\tO\nexamined\tO\nthe\tO\neffect\tO\nof\tO\nsystemic\tO\nadministration\tT-0\nof\tO\nketamine\tO\nand\tO\nlidocaine\tO\non\tO\nbrush\tO\n-\tO\nevoked\tT-1\n(\tO\ndynamic\tO\n)\tO\npain\tB-Disease\nand\tO\npunctate\tO\n-\tO\nevoked\tT-2\n(\tO\nstatic\tO\n)\tO\nhyperalgesia\tO\ninduced\tT-3\nby\tO\ncapsaicin\tO\n.\tO\n\nWe\tO\nhave\tO\nexamined\tO\nthe\tO\neffect\tO\nof\tO\nsystemic\tO\nadministration\tO\nof\tO\nketamine\tO\nand\tO\nlidocaine\tO\non\tO\nbrush\tO\n-\tO\nevoked\tT-0\n(\tO\ndynamic\tO\n)\tO\npain\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tT-1\n(\tO\nstatic\tO\n)\tO\nhyperalgesia\tB-Disease\ninduced\tT-2\nby\tO\ncapsaicin\tO\n.\tO\n\nWe\tO\nhave\tO\nexamined\tT-0\nthe\tO\neffect\tO\nof\tO\nsystemic\tO\nadministration\tT-1\nof\tO\nketamine\tO\nand\tO\nlidocaine\tO\non\tO\nbrush\tO\n-\tO\nevoked\tO\n(\tO\ndynamic\tO\n)\tO\npain\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\n(\tO\nstatic\tO\n)\tO\nhyperalgesia\tO\ninduced\tT-2\nby\tT-2\ncapsaicin\tB-Chemical\n.\tO\n\nCapsaicin\tB-Chemical\n100\tT-1\nmicrograms\tT-1\nwas\tT-1\ninjected\tT-1\nintradermally\tO\non\tO\nthe\tO\nvolar\tO\nforearm\tO\nfollowed\tO\nby\tO\nan\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusion\tO\nof\tO\nketamine\tO\n(\tO\nbolus\tO\n0\tO\n.\tO\n1\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nover\tO\n10\tO\nmin\tO\nfollowed\tO\nby\tO\ninfusion\tO\nof\tO\n7\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nmin\tO\n-\tO\n1\tO\n)\tO\n,\tO\nlidocaine\tO\n5\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nor\tO\nsaline\tO\nfor\tO\n50\tO\nmin\tO\n.\tO\n\nCapsaicin\tO\n100\tO\nmicrograms\tO\nwas\tO\ninjected\tO\nintradermally\tO\non\tO\nthe\tO\nvolar\tO\nforearm\tO\nfollowed\tO\nby\tO\nan\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusion\tT-0\nof\tT-0\nketamine\tB-Chemical\n(\tO\nbolus\tO\n0\tO\n.\tO\n1\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nover\tO\n10\tO\nmin\tO\nfollowed\tO\nby\tO\ninfusion\tO\nof\tO\n7\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nmin\tO\n-\tO\n1\tO\n)\tO\n,\tO\nlidocaine\tO\n5\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nor\tO\nsaline\tO\nfor\tO\n50\tO\nmin\tO\n.\tO\n\nCapsaicin\tO\n100\tO\nmicrograms\tO\nwas\tO\ninjected\tO\nintradermally\tO\non\tO\nthe\tO\nvolar\tO\nforearm\tO\nfollowed\tO\nby\tO\nan\tO\ni\tO\n.\tO\nv\tO\n.\tO\ninfusion\tO\nof\tO\nketamine\tO\n(\tO\nbolus\tO\n0\tO\n.\tO\n1\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nover\tO\n10\tO\nmin\tO\nfollowed\tO\nby\tO\ninfusion\tT-0\nof\tT-0\n7\tO\nmicrograms\tO\nkg\tO\n-\tO\n1\tO\nmin\tO\n-\tO\n1\tO\n)\tO\n,\tO\nlidocaine\tB-Chemical\n5\tO\nmg\tO\nkg\tO\n-\tO\n1\tO\nor\tO\nsaline\tO\nfor\tO\n50\tO\nmin\tO\n.\tO\n\nInfusion\tO\nstarted\tO\n15\tO\nmin\tO\nafter\tO\ninjection\tT-0\nof\tT-0\ncapsaicin\tB-Chemical\n.\tO\n\nThe\tO\nfollowing\tO\nwere\tO\nmeasured\tO\n:\tO\nspontaneous\tT-1\npain\tB-Disease\n,\tT-0\npain\tT-0\nevoked\tO\nby\tO\npunctate\tO\nand\tO\nbrush\tO\nstimuli\tO\n(\tO\nVAS\tO\n)\tO\n,\tO\nand\tO\nareas\tO\nof\tO\nbrush\tO\n-\tO\nevoked\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tO\n.\tO\n\nThe\tO\nfollowing\tO\nwere\tO\nmeasured\tO\n:\tO\nspontaneous\tO\npain\tO\n,\tO\npain\tB-Disease\nevoked\tT-0\nby\tT-0\npunctate\tO\nand\tO\nbrush\tO\nstimuli\tO\n(\tO\nVAS\tO\n)\tO\n,\tO\nand\tO\nareas\tO\nof\tO\nbrush\tO\n-\tO\nevoked\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tO\n.\tO\n\nThe\tO\nfollowing\tO\nwere\tO\nmeasured\tO\n:\tO\nspontaneous\tO\npain\tO\n,\tO\npain\tO\nevoked\tO\nby\tO\npunctate\tO\nand\tO\nbrush\tO\nstimuli\tO\n(\tO\nVAS\tO\n)\tO\n,\tO\nand\tO\nareas\tO\nof\tO\nbrush\tO\n-\tO\nevoked\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tT-0\nhyperalgesia\tB-Disease\n.\tO\n\nKetamine\tB-Chemical\nreduced\tT-0\nboth\tO\nthe\tO\narea\tO\nof\tO\nbrush\tO\n-\tO\nevoked\tO\nand\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tO\nsignificantly\tO\nand\tO\nit\tO\ntended\tO\nto\tO\nreduce\tO\nbrush\tO\n-\tO\nevoked\tO\npain\tO\n.\tO\n\nKetamine\tO\nreduced\tT-0\nboth\tO\nthe\tO\narea\tO\nof\tO\nbrush\tO\n-\tO\nevoked\tO\nand\tO\npunctate\tT-4\n-\tT-4\nevoked\tT-4\nhyperalgesia\tB-Disease\nsignificantly\tO\nand\tO\nit\tO\ntended\tO\nto\tO\nreduce\tT-1\nbrush\tO\n-\tO\nevoked\tT-3\npain\tO\n.\tO\n\nLidocaine\tB-Chemical\nreduced\tT-0\nthe\tO\narea\tO\nof\tO\npunctate\tO\n-\tO\nevoked\tO\nhyperalgesia\tO\nsignificantly\tO\n.\tO\n\nLidocaine\tO\nreduced\tO\nthe\tO\narea\tO\nof\tO\npunctate\tO\n-\tO\nevoked\tT-0\nhyperalgesia\tB-Disease\nsignificantly\tO\n.\tO\n\nIt\tO\ntended\tO\nto\tO\nreduce\tO\nVAS\tO\nscores\tO\nof\tO\nspontaneous\tT-1\npain\tB-Disease\nbut\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nevoked\tO\npain\tT-2\n.\tO\n\nIt\tO\ntended\tO\nto\tO\nreduce\tO\nVAS\tO\nscores\tO\nof\tO\nspontaneous\tO\npain\tO\nbut\tO\nhad\tO\nno\tT-0\neffect\tT-0\non\tT-0\nevoked\tT-1\npain\tB-Disease\n.\tO\n\nThe\tO\ndifferential\tT-2\neffects\tT-2\nof\tT-0\nketamine\tB-Chemical\nand\tO\nlidocaine\tO\non\tO\nstatic\tO\nand\tO\ndynamic\tO\nhyperalgesia\tO\nsuggest\tO\nthat\tO\nthe\tO\ntwo\tO\ntypes\tO\nof\tO\nhyperalgesia\tO\nare\tO\nmediated\tT-1\nby\tO\nseparate\tO\nmechanisms\tO\nand\tO\nhave\tO\na\tO\ndistinct\tO\npharmacology\tO\n.\tO\n\nThe\tO\ndifferential\tO\neffects\tT-0\nof\tT-0\nketamine\tT-1\nand\tT-1\nlidocaine\tB-Chemical\non\tO\nstatic\tO\nand\tO\ndynamic\tO\nhyperalgesia\tO\nsuggest\tO\nthat\tO\nthe\tO\ntwo\tO\ntypes\tO\nof\tO\nhyperalgesia\tO\nare\tO\nmediated\tO\nby\tO\nseparate\tO\nmechanisms\tO\nand\tO\nhave\tO\na\tO\ndistinct\tO\npharmacology\tO\n.\tO\n\nThe\tO\ndifferential\tO\neffects\tO\nof\tO\nketamine\tO\nand\tO\nlidocaine\tO\non\tO\nstatic\tT-0\nand\tT-0\ndynamic\tT-0\nhyperalgesia\tB-Disease\nsuggest\tO\nthat\tO\nthe\tO\ntwo\tO\ntypes\tO\nof\tO\nhyperalgesia\tO\nare\tO\nmediated\tT-1\nby\tO\nseparate\tO\nmechanisms\tO\nand\tO\nhave\tO\na\tO\ndistinct\tO\npharmacology\tO\n.\tO\n\nThe\tO\ndifferential\tO\neffects\tO\nof\tO\nketamine\tO\nand\tO\nlidocaine\tO\non\tO\nstatic\tO\nand\tO\ndynamic\tO\nhyperalgesia\tO\nsuggest\tT-2\nthat\tT-2\nthe\tO\ntwo\tO\ntypes\tT-0\nof\tT-0\nhyperalgesia\tB-Disease\nare\tT-1\nmediated\tT-1\nby\tT-1\nseparate\tO\nmechanisms\tO\nand\tO\nhave\tO\na\tO\ndistinct\tO\npharmacology\tO\n.\tO\n\nDevelopment\tT-2\nof\tT-2\napomorphine\tB-Chemical\n-\tO\ninduced\tT-3\naggressive\tO\nbehavior\tO\n:\tO\ncomparison\tO\nof\tO\nadult\tO\nmale\tO\nand\tO\nfemale\tO\nWistar\tO\nrats\tO\n.\tO\n\nDevelopment\tT-0\nof\tT-0\napomorphine\tO\n-\tO\ninduced\tT-1\naggressive\tB-Disease\nbehavior\tI-Disease\n:\tO\ncomparison\tO\nof\tO\nadult\tO\nmale\tO\nand\tO\nfemale\tO\nWistar\tO\nrats\tO\n.\tO\n\nThe\tO\ndevelopment\tT-0\nof\tT-0\napomorphine\tB-Chemical\n-\tT-1\ninduced\tT-1\n(\tO\n1\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nonce\tO\ndaily\tO\n)\tO\naggressive\tO\nbehavior\tO\nof\tO\nadult\tO\nmale\tO\nand\tO\nfemale\tO\nWistar\tO\nrats\tO\nobtained\tO\nfrom\tO\nthe\tO\nsame\tO\nbreeder\tO\nwas\tO\nstudied\tO\nin\tO\ntwo\tO\nconsecutive\tO\nsets\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\napomorphine\tO\n-\tO\ninduced\tT-0\n(\tO\n1\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nonce\tO\ndaily\tO\n)\tO\naggressive\tB-Disease\nbehavior\tI-Disease\nof\tT-1\nadult\tT-1\nmale\tT-1\nand\tO\nfemale\tO\nWistar\tO\nrats\tO\nobtained\tO\nfrom\tO\nthe\tO\nsame\tO\nbreeder\tO\nwas\tO\nstudied\tO\nin\tO\ntwo\tO\nconsecutive\tO\nsets\tO\n.\tO\n\nIn\tO\nmale\tO\nanimals\tO\n,\tO\nrepeated\tO\napomorphine\tB-Chemical\ntreatment\tT-0\ninduced\tO\na\tO\ngradual\tT-1\ndevelopment\tT-1\nof\tT-1\naggressive\tO\nbehavior\tO\nas\tO\nevidenced\tT-2\nby\tT-2\nthe\tO\nincreased\tO\nintensity\tO\nof\tO\naggressiveness\tO\nand\tO\nshortened\tO\nlatency\tO\nbefore\tO\nthe\tO\nfirst\tO\nattack\tO\ntoward\tO\nthe\tO\nopponent\tO\n.\tO\n\nIn\tO\nmale\tO\nanimals\tO\n,\tO\nrepeated\tO\napomorphine\tO\ntreatment\tT-0\ninduced\tT-2\na\tO\ngradual\tO\ndevelopment\tT-3\nof\tT-3\naggressive\tB-Disease\nbehavior\tI-Disease\nas\tO\nevidenced\tO\nby\tO\nthe\tO\nincreased\tO\nintensity\tO\nof\tO\naggressiveness\tO\nand\tO\nshortened\tO\nlatency\tO\nbefore\tO\nthe\tO\nfirst\tO\nattack\tO\ntoward\tO\nthe\tO\nopponent\tO\n.\tO\n\nIn\tO\nmale\tO\nanimals\tO\n,\tO\nrepeated\tO\napomorphine\tO\ntreatment\tO\ninduced\tT-1\na\tO\ngradual\tO\ndevelopment\tO\nof\tO\naggressive\tO\nbehavior\tO\nas\tO\nevidenced\tO\nby\tO\nthe\tO\nincreased\tT-2\nintensity\tT-0\nof\tT-0\naggressiveness\tB-Disease\nand\tO\nshortened\tO\nlatency\tO\nbefore\tO\nthe\tO\nfirst\tO\nattack\tO\ntoward\tO\nthe\tO\nopponent\tO\n.\tO\n\nIn\tO\nfemale\tO\nrats\tO\n,\tO\nonly\tO\na\tO\nweak\tO\ntendency\tT-1\ntoward\tT-1\naggressiveness\tB-Disease\nwas\tO\nfound\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\npresent\tO\nstudy\tO\ndemonstrates\tO\ngender\tO\ndifferences\tO\nin\tO\nthe\tO\ndevelopment\tT-0\nof\tT-0\nthe\tO\napomorphine\tB-Chemical\n-\tT-2\ninduced\tT-2\naggressive\tO\nbehavior\tO\nand\tO\nindicates\tO\nthat\tO\nthe\tO\nfemale\tO\nrats\tO\ndo\tO\nnot\tO\nfill\tO\nthe\tO\nvalidation\tO\ncriteria\tO\nfor\tO\nuse\tO\nin\tO\nthis\tO\nmethod\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nthe\tO\npresent\tO\nstudy\tO\ndemonstrates\tO\ngender\tO\ndifferences\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nthe\tO\napomorphine\tO\n-\tO\ninduced\tT-0\naggressive\tB-Disease\nbehavior\tI-Disease\nand\tO\nindicates\tO\nthat\tO\nthe\tO\nfemale\tO\nrats\tO\ndo\tO\nnot\tO\nfill\tO\nthe\tO\nvalidation\tO\ncriteria\tO\nfor\tO\nuse\tO\nin\tO\nthis\tO\nmethod\tO\n.\tO\n\nIntracranial\tB-Disease\naneurysms\tI-Disease\nand\tT-0\ncocaine\tO\nabuse\tO\n:\tO\nanalysis\tO\nof\tO\nprognostic\tO\nindicators\tO\n.\tO\n\nIntracranial\tO\naneurysms\tO\nand\tT-0\ncocaine\tB-Disease\nabuse\tI-Disease\n:\tO\nanalysis\tO\nof\tO\nprognostic\tO\nindicators\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tT-1\noutcome\tT-1\nof\tT-1\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\nassociated\tT-0\nwith\tT-0\ncocaine\tO\nabuse\tO\nis\tO\nreportedly\tO\npoor\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nThe\tO\noutcome\tO\nof\tO\nsubarachnoid\tO\nhemorrhage\tO\nassociated\tT-0\nwith\tT-0\ncocaine\tB-Disease\nabuse\tI-Disease\nis\tO\nreportedly\tO\npoor\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nreview\tO\nof\tO\nadmissions\tO\nduring\tO\na\tO\n6\tO\n-\tO\nyear\tO\nperiod\tO\nrevealed\tT-1\n14\tO\npatients\tO\nwith\tO\ncocaine\tB-Chemical\n-\tO\nrelated\tT-0\naneurysms\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nreview\tO\nof\tO\nadmissions\tO\nduring\tO\na\tO\n6\tO\n-\tO\nyear\tO\nperiod\tO\nrevealed\tO\n14\tO\npatients\tT-0\nwith\tT-0\ncocaine\tO\n-\tO\nrelated\tT-1\naneurysms\tB-Disease\n.\tO\n\nThis\tO\ngroup\tO\nwas\tO\ncompared\tT-0\nwith\tT-0\na\tO\ncontrol\tO\ngroup\tO\nof\tO\n135\tO\npatients\tT-1\nwith\tT-1\nruptured\tB-Disease\naneurysms\tI-Disease\nand\tO\nno\tO\nhistory\tO\nof\tO\ncocaine\tO\nabuse\tO\n.\tO\n\nThis\tO\ngroup\tO\nwas\tO\ncompared\tO\nwith\tO\na\tO\ncontrol\tO\ngroup\tO\nof\tO\n135\tO\npatients\tT-1\nwith\tO\nruptured\tO\naneurysms\tO\nand\tO\nno\tT-2\nhistory\tT-2\nof\tT-2\ncocaine\tB-Disease\nabuse\tI-Disease\n.\tO\n\nAge\tO\nat\tO\npresentation\tO\n,\tO\ntime\tO\nof\tO\nictus\tO\nafter\tO\nintoxication\tO\n,\tO\nHunt\tO\nand\tO\nHess\tO\ngrade\tT-2\nof\tT-2\nsubarachnoid\tB-Disease\nhemorrhage\tI-Disease\n,\tO\nsize\tT-0\nof\tT-0\nthe\tT-0\naneurysm\tT-0\n,\tO\nlocation\tT-1\nof\tT-1\nthe\tT-1\naneurysm\tT-1\n,\tO\nand\tO\nthe\tO\nGlasgow\tO\nOutcome\tO\nScale\tO\nscore\tO\nwere\tO\nassessed\tO\nand\tO\ncompared\tO\n.\tO\n\nAge\tO\nat\tO\npresentation\tO\n,\tO\ntime\tO\nof\tO\nictus\tO\nafter\tO\nintoxication\tO\n,\tO\nHunt\tO\nand\tO\nHess\tO\ngrade\tO\nof\tO\nsubarachnoid\tO\nhemorrhage\tO\n,\tO\nsize\tT-1\nof\tT-1\nthe\tT-1\naneurysm\tB-Disease\n,\tO\nlocation\tT-0\nof\tT-0\nthe\tO\naneurysm\tO\n,\tO\nand\tO\nthe\tO\nGlasgow\tO\nOutcome\tO\nScale\tO\nscore\tO\nwere\tO\nassessed\tO\nand\tO\ncompared\tO\n.\tO\n\nAge\tO\nat\tO\npresentation\tO\n,\tO\ntime\tO\nof\tO\nictus\tT-0\nafter\tO\nintoxication\tO\n,\tO\nHunt\tO\nand\tO\nHess\tO\ngrade\tO\nof\tO\nsubarachnoid\tO\nhemorrhage\tO\n,\tO\nsize\tO\nof\tO\nthe\tO\naneurysm\tO\n,\tO\nlocation\tT-1\nof\tT-1\nthe\tO\naneurysm\tB-Disease\n,\tO\nand\tO\nthe\tO\nGlasgow\tO\nOutcome\tO\nScale\tO\nscore\tO\nwere\tO\nassessed\tO\nand\tO\ncompared\tO\n.\tO\n\nIn\tO\npatients\tO\nin\tO\nthe\tO\nstudy\tO\ngroup\tO\n,\tO\nall\tT-0\naneurysms\tB-Disease\nwere\tT-1\nlocated\tT-1\nin\tO\nthe\tO\nanterior\tO\ncirculation\tO\n.\tO\n\nThe\tO\nmajority\tO\nof\tO\nthese\tO\naneurysms\tB-Disease\nwere\tO\nsmaller\tT-0\nthan\tT-0\nthose\tO\nof\tO\nthe\tO\ncontrol\tO\ngroup\tO\n(\tO\n8\tO\n+\tO\n/\tO\n-\tO\n6\tO\n.\tO\n08\tO\nmm\tO\nversus\tO\n11\tO\n+\tO\n/\tO\n-\tO\n5\tO\n.\tO\n4\tO\nmm\tO\n;\tO\nP\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nHunt\tO\nand\tO\nHess\tO\ngrade\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n005\tO\n)\tO\nand\tO\nage\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n007\tO\n)\tO\nwere\tO\nsignificant\tO\npredictors\tO\nof\tO\noutcome\tO\nfor\tO\nthe\tO\npatients\tT-0\nwith\tT-0\ncocaine\tB-Chemical\n-\tO\nrelated\tT-1\naneurysms\tO\n.\tO\n\nHunt\tO\nand\tO\nHess\tO\ngrade\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n005\tO\n)\tO\nand\tO\nage\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n007\tO\n)\tO\nwere\tO\nsignificant\tO\npredictors\tO\nof\tO\noutcome\tT-0\nfor\tO\nthe\tO\npatients\tT-1\nwith\tT-1\ncocaine\tO\n-\tO\nrelated\tT-2\naneurysms\tB-Disease\n.\tO\n\nCONCLUSION\tO\n:\tO\nCocaine\tB-Chemical\nuse\tT-0\npredisposed\tO\naneurysmal\tO\nrupture\tO\nat\tO\na\tO\nsignificantly\tO\nearlier\tO\nage\tO\nand\tO\nin\tO\nmuch\tO\nsmaller\tO\naneurysms\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nCocaine\tO\nuse\tO\npredisposed\tT-0\naneurysmal\tB-Disease\nrupture\tI-Disease\nat\tO\na\tO\nsignificantly\tO\nearlier\tO\nage\tO\nand\tO\nin\tO\nmuch\tO\nsmaller\tO\naneurysms\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nCocaine\tO\nuse\tO\npredisposed\tO\naneurysmal\tO\nrupture\tO\nat\tO\na\tO\nsignificantly\tT-0\nearlier\tT-0\nage\tT-0\nand\tO\nin\tO\nmuch\tO\nsmaller\tO\naneurysms\tB-Disease\n.\tO\n\nEffect\tT-0\nof\tT-0\nintravenous\tO\nnimodipine\tB-Chemical\non\tO\nblood\tO\npressure\tO\nand\tO\noutcome\tO\nafter\tO\nacute\tO\nstroke\tO\n.\tO\n\nEffect\tO\nof\tO\nintravenous\tO\nnimodipine\tO\non\tO\nblood\tO\npressure\tO\nand\tO\noutcome\tO\nafter\tT-0\nacute\tB-Disease\nstroke\tI-Disease\n.\tO\n\nBACKGROUND\tO\nAND\tO\nPURPOSE\tO\n:\tO\nThe\tT-0\nIntravenous\tT-0\nNimodipine\tB-Chemical\nWest\tO\nEuropean\tO\nStroke\tO\nTrial\tO\n(\tO\nINWEST\tO\n)\tO\nfound\tO\na\tO\ncorrelation\tO\nbetween\tO\nnimodipine\tO\n-\tO\ninduced\tT-1\nreduction\tO\nin\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\nand\tO\nan\tO\nunfavorable\tT-2\noutcome\tT-2\nin\tO\nacute\tO\nstroke\tO\n.\tO\n\nBACKGROUND\tO\nAND\tO\nPURPOSE\tO\n:\tO\nThe\tO\nIntravenous\tO\nNimodipine\tO\nWest\tO\nEuropean\tO\nStroke\tB-Disease\nTrial\tT-0\n(\tO\nINWEST\tO\n)\tO\nfound\tO\na\tO\ncorrelation\tO\nbetween\tO\nnimodipine\tO\n-\tO\ninduced\tO\nreduction\tO\nin\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\nand\tO\nan\tO\nunfavorable\tO\noutcome\tO\nin\tO\nacute\tO\nstroke\tO\n.\tO\n\nBACKGROUND\tO\nAND\tO\nPURPOSE\tO\n:\tO\nThe\tO\nIntravenous\tO\nNimodipine\tO\nWest\tO\nEuropean\tO\nStroke\tO\nTrial\tO\n(\tO\nINWEST\tO\n)\tO\nfound\tO\na\tO\ncorrelation\tT-0\nbetween\tO\nnimodipine\tB-Chemical\n-\tO\ninduced\tT-1\nreduction\tO\nin\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\nand\tO\nan\tO\nunfavorable\tO\noutcome\tO\nin\tO\nacute\tO\nstroke\tO\n.\tO\n\nBACKGROUND\tO\nAND\tO\nPURPOSE\tO\n:\tO\nThe\tO\nIntravenous\tO\nNimodipine\tO\nWest\tO\nEuropean\tO\nStroke\tO\nTrial\tO\n(\tO\nINWEST\tO\n)\tO\nfound\tO\na\tO\ncorrelation\tO\nbetween\tO\nnimodipine\tO\n-\tO\ninduced\tT-0\nreduction\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\n(\tO\nBP\tO\n)\tO\nand\tO\nan\tO\nunfavorable\tO\noutcome\tO\nin\tO\nacute\tO\nstroke\tO\n.\tO\n\nBACKGROUND\tO\nAND\tO\nPURPOSE\tO\n:\tO\nThe\tO\nIntravenous\tO\nNimodipine\tO\nWest\tO\nEuropean\tO\nStroke\tO\nTrial\tO\n(\tO\nINWEST\tO\n)\tO\nfound\tO\na\tO\ncorrelation\tO\nbetween\tO\nnimodipine\tO\n-\tO\ninduced\tO\nreduction\tO\nin\tO\nblood\tO\npressure\tO\n(\tO\nBP\tO\n)\tO\nand\tO\nan\tO\nunfavorable\tT-1\noutcome\tT-1\nin\tT-1\nacute\tB-Disease\nstroke\tI-Disease\n.\tO\n\nWe\tO\nsought\tO\nto\tO\nconfirm\tO\nthis\tO\ncorrelation\tO\nwith\tO\nand\tO\nwithout\tO\nadjustment\tO\nfor\tO\nprognostic\tO\nvariables\tO\nand\tO\nto\tO\ninvestigate\tO\noutcome\tO\nin\tO\nsubgroups\tO\nwith\tO\nincreasing\tT-1\nlevels\tT-0\nof\tT-0\nBP\tB-Disease\nreduction\tI-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nPatients\tO\nwith\tO\na\tO\nclinical\tT-0\ndiagnosis\tT-1\nof\tT-1\nischemic\tB-Disease\nstroke\tI-Disease\n(\tO\nwithin\tO\n24\tO\nhours\tO\n)\tO\nwere\tO\nconsecutively\tO\nallocated\tO\nto\tO\nreceive\tO\nplacebo\tO\n(\tO\nn\tO\n=\tO\n100\tO\n)\tO\n,\tO\n1\tO\nmg\tO\n/\tO\nh\tO\n(\tO\nlow\tO\n-\tO\ndose\tO\n)\tO\nnimodipine\tO\n(\tO\nn\tO\n=\tO\n101\tO\n)\tO\n,\tO\nor\tO\n2\tO\nmg\tO\n/\tO\nh\tO\n(\tO\nhigh\tO\n-\tO\ndose\tO\n)\tO\nnimodipine\tO\n(\tO\nn\tO\n=\tO\n94\tO\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nPatients\tO\nwith\tO\na\tO\nclinical\tO\ndiagnosis\tO\nof\tO\nischemic\tO\nstroke\tO\n(\tO\nwithin\tO\n24\tO\nhours\tO\n)\tO\nwere\tO\nconsecutively\tO\nallocated\tT-1\nto\tT-1\nreceive\tO\nplacebo\tO\n(\tO\nn\tO\n=\tO\n100\tO\n)\tO\n,\tO\n1\tT-0\nmg\tT-0\n/\tT-0\nh\tT-0\n(\tT-0\nlow\tT-0\n-\tT-0\ndose\tT-0\n)\tT-0\nnimodipine\tB-Chemical\n(\tO\nn\tO\n=\tO\n101\tO\n)\tO\n,\tO\nor\tO\n2\tO\nmg\tO\n/\tO\nh\tO\n(\tO\nhigh\tO\n-\tO\ndose\tO\n)\tO\nnimodipine\tO\n(\tO\nn\tO\n=\tO\n94\tO\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nPatients\tO\nwith\tO\na\tO\nclinical\tO\ndiagnosis\tO\nof\tO\nischemic\tO\nstroke\tO\n(\tO\nwithin\tO\n24\tO\nhours\tO\n)\tO\nwere\tO\nconsecutively\tO\nallocated\tT-1\nto\tT-1\nreceive\tT-0\nplacebo\tO\n(\tO\nn\tO\n=\tO\n100\tO\n)\tO\n,\tO\n1\tO\nmg\tO\n/\tO\nh\tO\n(\tO\nlow\tO\n-\tO\ndose\tO\n)\tO\nnimodipine\tO\n(\tO\nn\tO\n=\tO\n101\tO\n)\tO\n,\tO\nor\tO\n2\tO\nmg\tO\n/\tO\nh\tO\n(\tO\nhigh\tO\n-\tO\ndose\tO\n)\tO\nnimodipine\tB-Chemical\n(\tO\nn\tO\n=\tO\n94\tO\n)\tO\n.\tO\n\nNimodipine\tB-Chemical\ntreatment\tT-3\nresulted\tT-3\nin\tT-3\na\tO\nstatistically\tO\nsignificant\tO\nreduction\tT-2\nin\tT-2\nsystolic\tO\nBP\tO\n(\tO\nSBP\tO\n)\tO\nand\tO\ndiastolic\tO\nBP\tO\n(\tO\nDBP\tO\n)\tO\nfrom\tO\nbaseline\tO\ncompared\tO\nwith\tO\nplacebo\tO\nduring\tO\nthe\tO\nfirst\tO\nfew\tO\ndays\tO\n.\tO\n\nNimodipine\tO\ntreatment\tO\nresulted\tT-1\nin\tT-1\na\tO\nstatistically\tT-0\nsignificant\tT-0\nreduction\tB-Disease\nin\tI-Disease\nsystolic\tI-Disease\nBP\tI-Disease\n(\tO\nSBP\tO\n)\tO\nand\tO\ndiastolic\tO\nBP\tO\n(\tO\nDBP\tO\n)\tO\nfrom\tO\nbaseline\tO\ncompared\tO\nwith\tO\nplacebo\tO\nduring\tO\nthe\tO\nfirst\tO\nfew\tO\ndays\tO\n.\tO\n\nIn\tO\nmultivariate\tO\nanalysis\tO\n,\tO\na\tO\nsignificant\tO\ncorrelation\tO\nbetween\tT-0\nDBP\tB-Disease\nreduction\tI-Disease\nand\tO\nworsening\tT-1\nof\tO\nthe\tO\nneurological\tO\nscore\tO\nwas\tO\nfound\tO\nfor\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\n(\tO\nbeta\tO\n=\tO\n0\tO\n.\tO\n49\tO\n,\tO\nP\tO\n=\tO\n0\tO\n.\tO\n048\tO\n)\tO\n.\tO\n\nPatients\tO\nwith\tO\na\tO\nDBP\tB-Disease\nreduction\tI-Disease\nof\tO\n>\tO\nor\tO\n=\tO\n20\tO\n%\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\nhad\tO\na\tO\nsignificantly\tO\nincreased\tT-0\nadjusted\tT-0\nOR\tO\nfor\tO\nthe\tO\ncompound\tO\noutcome\tO\nvariable\tO\ndeath\tO\nor\tO\ndependency\tO\n(\tO\nBarthel\tO\nIndex\tO\n<\tO\n60\tO\n)\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n25\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n10\tO\n.\tO\n16\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n02\tO\nto\tO\n101\tO\n.\tO\n74\tO\n)\tO\nand\tO\ndeath\tO\nalone\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n9\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n4\tO\n.\tO\n336\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n131\tO\n16\tO\n.\tO\n619\tO\n)\tO\ncompared\tO\nwith\tO\nall\tO\nplacebo\tO\npatients\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n62\tO\n/\tO\n92\tO\nand\tO\n14\tO\n/\tO\n92\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nPatients\tO\nwith\tO\na\tO\nDBP\tO\nreduction\tO\nof\tO\n>\tO\nor\tO\n=\tO\n20\tO\n%\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\nhad\tO\na\tO\nsignificantly\tO\nincreased\tO\nadjusted\tO\nOR\tO\nfor\tO\nthe\tO\ncompound\tO\noutcome\tO\nvariable\tO\ndeath\tB-Disease\nor\tT-0\ndependency\tO\n(\tO\nBarthel\tO\nIndex\tO\n<\tO\n60\tO\n)\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n25\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n10\tO\n.\tO\n16\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n02\tO\nto\tO\n101\tO\n.\tO\n74\tO\n)\tO\nand\tO\ndeath\tO\nalone\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n9\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n4\tO\n.\tO\n336\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n131\tO\n16\tO\n.\tO\n619\tO\n)\tO\ncompared\tO\nwith\tO\nall\tO\nplacebo\tO\npatients\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n62\tO\n/\tO\n92\tO\nand\tO\n14\tO\n/\tO\n92\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nPatients\tO\nwith\tO\na\tO\nDBP\tO\nreduction\tT-2\nof\tT-2\n>\tO\nor\tO\n=\tO\n20\tO\n%\tO\nin\tO\nthe\tO\nhigh\tO\n-\tO\ndose\tO\ngroup\tO\nhad\tO\na\tO\nsignificantly\tO\nincreased\tO\nadjusted\tO\nOR\tO\nfor\tO\nthe\tO\ncompound\tO\noutcome\tO\nvariable\tO\ndeath\tT-0\nor\tO\ndependency\tT-1\n(\tO\nBarthel\tO\nIndex\tO\n<\tO\n60\tO\n)\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n25\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n10\tO\n.\tO\n16\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n02\tO\nto\tO\n101\tO\n.\tO\n74\tO\n)\tO\nand\tO\ndeath\tB-Disease\nalone\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n9\tO\n/\tO\n26\tO\n,\tO\nOR\tO\n4\tO\n.\tO\n336\tO\n,\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n131\tO\n16\tO\n.\tO\n619\tO\n)\tO\ncompared\tO\nwith\tO\nall\tO\nplacebo\tO\npatients\tO\n(\tO\nn\tO\n/\tO\nN\tO\n=\tO\n62\tO\n/\tO\n92\tO\nand\tO\n14\tO\n/\tO\n92\tO\n,\tO\nrespectively\tO\n)\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDBP\tO\n,\tO\nbut\tO\nnot\tO\nSBP\tO\n,\tO\nreduction\tO\nwas\tO\nassociated\tO\nwith\tO\nneurological\tO\nworsening\tO\nafter\tO\nthe\tO\nintravenous\tO\nadministration\tT-1\nof\tT-1\nhigh\tO\n-\tO\ndose\tT-0\nnimodipine\tB-Chemical\nafter\tO\nacute\tO\nstroke\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDBP\tO\n,\tO\nbut\tO\nnot\tO\nSBP\tO\n,\tO\nreduction\tO\nwas\tO\nassociated\tO\nwith\tO\nneurological\tO\nworsening\tO\nafter\tO\nthe\tO\nintravenous\tO\nadministration\tO\nof\tO\nhigh\tO\n-\tO\ndose\tO\nnimodipine\tO\nafter\tT-0\nacute\tB-Disease\nstroke\tI-Disease\n.\tO\n\nFor\tO\nlow\tT-2\n-\tT-2\ndose\tT-2\nnimodipine\tB-Chemical\n,\tO\nthe\tT-0\nresults\tT-0\nwere\tT-1\nnot\tO\nconclusive\tO\n.\tO\n\nThese\tO\nresults\tO\ndo\tO\nnot\tO\nconfirm\tO\nor\tO\nexclude\tO\na\tO\nneuroprotective\tO\nproperty\tT-0\nof\tT-0\nnimodipine\tB-Chemical\n.\tO\n\nNeonatal\tT-0\npyridoxine\tB-Chemical\nresponsive\tT-1\nconvulsions\tO\ndue\tT-2\nto\tT-2\nisoniazid\tO\ntherapy\tO\n.\tO\n\nNeonatal\tO\npyridoxine\tO\nresponsive\tT-0\nconvulsions\tB-Disease\ndue\tO\nto\tO\nisoniazid\tO\ntherapy\tO\n.\tO\n\nNeonatal\tO\npyridoxine\tO\nresponsive\tO\nconvulsions\tT-0\ndue\tT-1\nto\tT-1\nisoniazid\tB-Chemical\ntherapy\tT-2\n.\tO\n\nA\tO\n17\tO\n-\tO\nday\tO\n-\tO\nold\tO\ninfant\tO\non\tT-0\nisoniazid\tB-Chemical\ntherapy\tT-1\n13\tO\nmg\tO\n/\tO\nkg\tO\ndaily\tO\nfrom\tO\nbirth\tO\nbecause\tO\nof\tO\nmaternal\tO\ntuberculosis\tO\nwas\tO\nadmitted\tO\nafter\tO\n4\tO\ndays\tO\nof\tO\nclonic\tO\nfits\tO\n.\tO\n\nA\tO\n17\tO\n-\tO\nday\tO\n-\tO\nold\tO\ninfant\tO\non\tO\nisoniazid\tO\ntherapy\tO\n13\tO\nmg\tO\n/\tO\nkg\tO\ndaily\tO\nfrom\tO\nbirth\tO\nbecause\tO\nof\tO\nmaternal\tO\ntuberculosis\tB-Disease\nwas\tO\nadmitted\tO\nafter\tO\n4\tO\ndays\tO\nof\tO\nclonic\tT-0\nfits\tT-0\n.\tO\n\nA\tO\n17\tO\n-\tO\nday\tO\n-\tO\nold\tO\ninfant\tO\non\tO\nisoniazid\tO\ntherapy\tO\n13\tO\nmg\tO\n/\tO\nkg\tO\ndaily\tO\nfrom\tO\nbirth\tO\nbecause\tO\nof\tO\nmaternal\tO\ntuberculosis\tO\nwas\tO\nadmitted\tO\nafter\tO\n4\tT-0\ndays\tT-0\nof\tT-0\nclonic\tB-Disease\nfits\tI-Disease\n.\tO\n\nThe\tO\nfits\tB-Disease\nceased\tT-0\nwithin\tT-0\n4\tO\nhours\tO\nof\tO\nadministering\tO\nintramuscular\tO\npyridoxine\tO\n,\tO\nsuggesting\tT-1\nan\tO\naetiology\tO\nof\tO\npyridoxine\tO\ndeficiency\tO\nsecondary\tO\nto\tO\nisoniazid\tO\nmedication\tO\n.\tO\n\nThe\tO\nfits\tO\nceased\tO\nwithin\tO\n4\tO\nhours\tO\nof\tO\nadministering\tT-1\nintramuscular\tT-1\npyridoxine\tB-Chemical\n,\tO\nsuggesting\tO\nan\tO\naetiology\tO\nof\tO\npyridoxine\tO\ndeficiency\tO\nsecondary\tO\nto\tO\nisoniazid\tO\nmedication\tO\n.\tO\n\nThe\tO\nfits\tO\nceased\tO\nwithin\tO\n4\tO\nhours\tO\nof\tO\nadministering\tT-1\nintramuscular\tO\npyridoxine\tO\n,\tO\nsuggesting\tO\nan\tO\naetiology\tO\nof\tO\npyridoxine\tB-Chemical\ndeficiency\tO\nsecondary\tO\nto\tO\nisoniazid\tO\nmedication\tO\n.\tO\n\nThe\tO\nfits\tO\nceased\tO\nwithin\tO\n4\tO\nhours\tO\nof\tO\nadministering\tO\nintramuscular\tO\npyridoxine\tO\n,\tO\nsuggesting\tO\nan\tO\naetiology\tO\nof\tO\npyridoxine\tO\ndeficiency\tO\nsecondary\tT-0\nto\tT-0\nisoniazid\tB-Chemical\nmedication\tT-1\n.\tO\n\nKetamine\tB-Chemical\nsedation\tT-0\nfor\tO\nthe\tO\nreduction\tT-1\nof\tO\nchildren\tO\n'\tO\ns\tO\nfractures\tO\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tO\n\nKetamine\tO\nsedation\tO\nfor\tO\nthe\tO\nreduction\tT-0\nof\tT-0\nchildren\tO\n'\tO\ns\tO\nfractures\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThere\tO\nrecently\tO\nhas\tO\nbeen\tO\na\tO\nresurgence\tO\nin\tO\nthe\tO\nutilization\tT-0\nof\tT-0\nketamine\tB-Chemical\n,\tO\na\tO\nunique\tO\nanesthetic\tO\n,\tO\nfor\tO\nemergency\tO\n-\tO\ndepartment\tO\nprocedures\tO\nrequiring\tO\nsedation\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tT-0\nto\tT-0\nexamine\tT-0\nthe\tO\nsafety\tO\nand\tO\nefficacy\tT-2\nof\tT-2\nketamine\tB-Chemical\nfor\tT-3\nsedation\tT-3\nin\tT-1\nthe\tT-1\ntreatment\tT-1\nof\tO\nchildren\tO\n'\tO\ns\tO\nfractures\tO\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\nsafety\tO\nand\tO\nefficacy\tO\nof\tO\nketamine\tO\nfor\tO\nsedation\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tT-0\nchildren\tO\n'\tO\ns\tO\nfractures\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\n.\tT-0\n\nMETHODS\tO\n:\tO\nOne\tO\nhundred\tO\nand\tO\nfourteen\tO\nchildren\tO\n(\tO\naverage\tO\nage\tO\n,\tO\n5\tO\n.\tO\n3\tO\nyears\tO\n;\tO\nrange\tO\n,\tO\ntwelve\tO\nmonths\tO\nto\tO\nten\tO\nyears\tO\nand\tO\nten\tO\nmonths\tO\n)\tO\nwho\tO\nunderwent\tO\nclosed\tT-2\nreduction\tT-2\nof\tO\nan\tO\nisolated\tT-3\nfracture\tB-Disease\nor\tO\ndislocation\tT-1\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nat\tO\na\tO\nlevel\tO\n-\tO\nI\tO\ntrauma\tO\ncenter\tO\nwere\tO\nprospectively\tO\nevaluated\tO\n.\tO\n\nMETHODS\tO\n:\tO\nOne\tO\nhundred\tO\nand\tO\nfourteen\tO\nchildren\tO\n(\tO\naverage\tO\nage\tO\n,\tO\n5\tO\n.\tO\n3\tO\nyears\tO\n;\tO\nrange\tO\n,\tO\ntwelve\tO\nmonths\tO\nto\tO\nten\tO\nyears\tO\nand\tO\nten\tO\nmonths\tO\n)\tO\nwho\tO\nunderwent\tT-1\nclosed\tO\nreduction\tO\nof\tO\nan\tO\nisolated\tO\nfracture\tT-0\nor\tT-0\ndislocation\tB-Disease\nin\tT-2\nthe\tT-2\nemergency\tT-2\ndepartment\tT-2\nat\tO\na\tO\nlevel\tO\n-\tO\nI\tO\ntrauma\tO\ncenter\tO\nwere\tO\nprospectively\tO\nevaluated\tO\n.\tO\n\nMETHODS\tO\n:\tO\nOne\tO\nhundred\tO\nand\tO\nfourteen\tO\nchildren\tO\n(\tO\naverage\tO\nage\tO\n,\tO\n5\tO\n.\tO\n3\tO\nyears\tO\n;\tO\nrange\tO\n,\tO\ntwelve\tO\nmonths\tO\nto\tO\nten\tO\nyears\tO\nand\tO\nten\tO\nmonths\tO\n)\tO\nwho\tO\nunderwent\tO\nclosed\tO\nreduction\tO\nof\tO\nan\tO\nisolated\tO\nfracture\tO\nor\tO\ndislocation\tO\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nat\tO\na\tO\nlevel\tT-0\n-\tT-0\nI\tT-0\ntrauma\tB-Disease\ncenter\tO\nwere\tO\nprospectively\tO\nevaluated\tO\n.\tO\n\nKetamine\tB-Chemical\nhydrochloride\tI-Chemical\nwas\tT-0\nadministered\tT-0\nintravenously\tO\n(\tO\nat\tO\na\tO\ndose\tO\nof\tO\ntwo\tO\nmilligrams\tO\nper\tO\nkilogram\tO\nof\tO\nbody\tO\nweight\tO\n)\tO\nin\tO\nninety\tO\n-\tO\nnine\tO\nof\tO\nthe\tO\npatients\tO\nand\tO\nintramuscularly\tO\n(\tO\nat\tO\na\tO\ndose\tO\nof\tO\nfour\tO\nmilligrams\tO\nper\tO\nkilogram\tO\nof\tO\nbody\tO\nweight\tO\n)\tO\nin\tO\nthe\tO\nother\tO\nfifteen\tO\n.\tO\n\nAny\tT-0\npain\tB-Disease\nduring\tT-1\nthe\tO\nreduction\tO\nwas\tO\nrated\tO\nby\tO\nthe\tO\northopaedic\tO\nsurgeon\tO\ntreating\tO\nthe\tO\npatient\tO\naccording\tO\nto\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nof\tO\nEastern\tO\nOntario\tO\nPain\tO\nScale\tO\n(\tO\nCHEOPS\tO\n)\tO\n.\tO\n\nAny\tO\npain\tO\nduring\tO\nthe\tO\nreduction\tT-0\nwas\tO\nrated\tO\nby\tO\nthe\tO\northopaedic\tO\nsurgeon\tO\ntreating\tO\nthe\tO\npatient\tO\naccording\tO\nto\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nof\tO\nEastern\tO\nOntario\tO\nPain\tB-Disease\nScale\tO\n(\tO\nCHEOPS\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\naverage\tO\ntime\tO\nfrom\tO\nintravenous\tO\nadministration\tT-0\nof\tT-0\nketamine\tB-Chemical\nto\tO\nmanipulation\tO\nof\tO\nthe\tO\nfracture\tO\nor\tO\ndislocation\tO\nwas\tO\none\tO\nminute\tO\nand\tO\nthirty\tO\n-\tO\nsix\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\ntwenty\tO\nseconds\tO\nto\tO\nfive\tO\nminutes\tO\n)\tO\n,\tO\nand\tO\nthe\tO\naverage\tO\ntime\tO\nfrom\tO\nintramuscular\tO\nadministration\tO\nto\tO\nmanipulation\tT-1\nwas\tO\nfour\tO\nminutes\tO\nand\tO\nforty\tO\n-\tO\ntwo\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\nsixty\tO\nseconds\tO\nto\tO\nfifteen\tO\nminutes\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\naverage\tO\ntime\tO\nfrom\tO\nintravenous\tO\nadministration\tO\nof\tO\nketamine\tO\nto\tO\nmanipulation\tT-1\nof\tT-1\nthe\tT-0\nfracture\tB-Disease\nor\tO\ndislocation\tO\nwas\tO\none\tO\nminute\tO\nand\tO\nthirty\tO\n-\tO\nsix\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\ntwenty\tO\nseconds\tO\nto\tO\nfive\tO\nminutes\tO\n)\tO\n,\tO\nand\tO\nthe\tO\naverage\tO\ntime\tO\nfrom\tO\nintramuscular\tO\nadministration\tO\nto\tO\nmanipulation\tO\nwas\tO\nfour\tO\nminutes\tO\nand\tO\nforty\tO\n-\tO\ntwo\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\nsixty\tO\nseconds\tO\nto\tO\nfifteen\tO\nminutes\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\naverage\tO\ntime\tO\nfrom\tO\nintravenous\tO\nadministration\tO\nof\tO\nketamine\tO\nto\tO\nmanipulation\tT-1\nof\tT-1\nthe\tO\nfracture\tO\nor\tT-0\ndislocation\tB-Disease\nwas\tO\none\tO\nminute\tO\nand\tO\nthirty\tO\n-\tO\nsix\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\ntwenty\tO\nseconds\tO\nto\tO\nfive\tO\nminutes\tO\n)\tO\n,\tO\nand\tO\nthe\tO\naverage\tO\ntime\tO\nfrom\tO\nintramuscular\tO\nadministration\tO\nto\tO\nmanipulation\tO\nwas\tO\nfour\tO\nminutes\tO\nand\tO\nforty\tO\n-\tO\ntwo\tO\nseconds\tO\n(\tO\nrange\tO\n,\tO\nsixty\tO\nseconds\tO\nto\tO\nfifteen\tO\nminutes\tO\n)\tO\n.\tO\n\nThe\tO\naverage\tO\nscore\tO\naccording\tT-0\nto\tT-0\nthe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nof\tO\nEastern\tO\nOntario\tO\nPain\tB-Disease\nScale\tT-2\nwas\tO\n6\tO\n.\tO\n4\tO\npoints\tO\n(\tO\nrange\tO\n,\tO\n5\tO\nto\tO\n10\tO\npoints\tO\n)\tO\n,\tO\nreflecting\tT-1\nminimal\tO\nor\tO\nno\tO\npain\tO\nduring\tO\nfracture\tO\nreduction\tO\n.\tO\n\nThe\tO\naverage\tO\nscore\tO\naccording\tO\nto\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nof\tO\nEastern\tO\nOntario\tO\nPain\tO\nScale\tO\nwas\tO\n6\tO\n.\tO\n4\tO\npoints\tO\n(\tO\nrange\tO\n,\tO\n5\tO\nto\tO\n10\tO\npoints\tO\n)\tO\n,\tO\nreflecting\tT-0\nminimal\tO\nor\tO\nno\tO\npain\tB-Disease\nduring\tO\nfracture\tO\nreduction\tO\n.\tO\n\nThe\tO\naverage\tO\nscore\tO\naccording\tO\nto\tO\nthe\tO\nChildren\tO\n'\tO\ns\tO\nHospital\tO\nof\tO\nEastern\tO\nOntario\tO\nPain\tO\nScale\tO\nwas\tO\n6\tO\n.\tO\n4\tO\npoints\tO\n(\tO\nrange\tO\n,\tO\n5\tO\nto\tO\n10\tO\npoints\tO\n)\tO\n,\tO\nreflecting\tO\nminimal\tT-2\nor\tT-2\nno\tT-2\npain\tT-2\nduring\tT-0\nfracture\tB-Disease\nreduction\tT-1\n.\tO\n\nAdequate\tO\nfracture\tB-Disease\nreduction\tT-0\nwas\tO\nobtained\tO\nin\tO\n111\tO\nof\tO\nthe\tO\nchildren\tO\n.\tO\n\nMinor\tO\nside\tO\neffects\tO\nincluded\tO\nnausea\tB-Disease\n(\tO\nthirteen\tO\npatients\tO\n)\tO\n,\tO\nemesis\tO\n(\tO\neight\tO\nof\tO\nthe\tO\nthirteen\tO\npatients\tO\nwith\tO\nnausea\tO\n)\tO\n,\tO\nclumsiness\tO\n(\tO\nevident\tO\nas\tO\nataxic\tO\nmovements\tO\nin\tO\nten\tO\npatients\tO\n)\tO\n,\tO\nand\tO\ndysphoric\tO\nreaction\tT-0\n(\tO\none\tO\npatient\tO\n)\tO\n.\tO\n\nMinor\tO\nside\tO\neffects\tO\nincluded\tO\nnausea\tO\n(\tT-0\nthirteen\tT-0\npatients\tT-0\n)\tT-0\n,\tT-0\nemesis\tB-Disease\n(\tT-1\neight\tT-1\nof\tT-1\nthe\tT-1\nthirteen\tT-1\npatients\tT-1\nwith\tT-1\nnausea\tT-1\n)\tT-1\n,\tO\nclumsiness\tO\n(\tO\nevident\tO\nas\tO\nataxic\tO\nmovements\tO\nin\tO\nten\tO\npatients\tO\n)\tO\n,\tO\nand\tO\ndysphoric\tO\nreaction\tT-2\n(\tO\none\tO\npatient\tO\n)\tO\n.\tO\n\nMinor\tO\nside\tO\neffects\tO\nincluded\tT-1\nnausea\tO\n(\tO\nthirteen\tO\npatients\tO\n)\tO\n,\tO\nemesis\tO\n(\tO\neight\tO\nof\tO\nthe\tO\nthirteen\tO\npatients\tO\nwith\tO\nnausea\tB-Disease\n)\tO\n,\tO\nclumsiness\tO\n(\tO\nevident\tO\nas\tO\nataxic\tO\nmovements\tO\nin\tO\nten\tO\npatients\tO\n)\tO\n,\tO\nand\tO\ndysphoric\tO\nreaction\tT-0\n(\tO\none\tO\npatient\tO\n)\tO\n.\tO\n\nMinor\tO\nside\tO\neffects\tO\nincluded\tT-1\nnausea\tO\n(\tO\nthirteen\tO\npatients\tO\n)\tO\n,\tO\nemesis\tO\n(\tT-2\neight\tT-2\nof\tT-2\nthe\tT-2\nthirteen\tT-2\npatients\tT-2\nwith\tT-2\nnausea\tT-2\n)\tT-2\n,\tT-2\nclumsiness\tB-Disease\n(\tT-3\nevident\tT-3\nas\tT-3\nataxic\tT-3\nmovements\tT-3\nin\tT-3\nten\tT-3\npatients\tT-3\n)\tT-3\n,\tO\nand\tO\ndysphoric\tO\nreaction\tT-0\n(\tO\none\tO\npatient\tO\n)\tO\n.\tO\n\nMinor\tO\nside\tO\neffects\tO\nincluded\tO\nnausea\tO\n(\tO\nthirteen\tO\npatients\tO\n)\tO\n,\tO\nemesis\tO\n(\tO\neight\tO\nof\tO\nthe\tO\nthirteen\tO\npatients\tO\nwith\tO\nnausea\tO\n)\tO\n,\tO\nclumsiness\tO\n(\tO\nevident\tT-0\nas\tT-0\nataxic\tB-Disease\nmovements\tI-Disease\nin\tO\nten\tO\npatients\tO\n)\tO\n,\tO\nand\tO\ndysphoric\tO\nreaction\tT-1\n(\tO\none\tO\npatient\tO\n)\tO\n.\tO\n\nMinor\tO\nside\tO\neffects\tO\nincluded\tO\nnausea\tO\n(\tO\nthirteen\tO\npatients\tO\n)\tO\n,\tO\nemesis\tO\n(\tO\neight\tO\nof\tO\nthe\tO\nthirteen\tO\npatients\tO\nwith\tO\nnausea\tO\n)\tO\n,\tO\nclumsiness\tO\n(\tO\nevident\tO\nas\tO\nataxic\tO\nmovements\tO\nin\tO\nten\tO\npatients\tO\n)\tO\n,\tO\nand\tO\ndysphoric\tB-Disease\nreaction\tI-Disease\n(\tT-0\none\tT-0\npatient\tT-0\n)\tT-0\n.\tO\n\nNo\tO\nlong\tO\n-\tO\nterm\tO\nsequelae\tO\nwere\tO\nnoted\tO\n,\tO\nand\tO\nno\tT-0\npatients\tT-0\nhad\tT-0\nhallucinations\tB-Disease\nor\tO\nnightmares\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nKetamine\tB-Chemical\nreliably\tO\n,\tO\nsafely\tO\n,\tO\nand\tO\nquickly\tO\nprovided\tT-0\nadequate\tO\nsedation\tT-1\nto\tT-1\neffectively\tO\nfacilitate\tT-2\nthe\tT-2\nreduction\tT-2\nof\tT-2\nchildren\tO\n'\tO\ns\tO\nfractures\tO\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nat\tO\nour\tO\ninstitution\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nKetamine\tO\nreliably\tO\n,\tO\nsafely\tO\n,\tO\nand\tO\nquickly\tO\nprovided\tO\nadequate\tO\nsedation\tO\nto\tO\neffectively\tO\nfacilitate\tO\nthe\tO\nreduction\tT-0\nof\tT-0\nchildren\tO\n'\tO\ns\tO\nfractures\tB-Disease\nin\tO\nthe\tO\nemergency\tO\ndepartment\tO\nat\tO\nour\tO\ninstitution\tO\n.\tO\n\nKetamine\tB-Chemical\nshould\tT-0\nonly\tT-0\nbe\tT-1\nused\tT-1\nin\tT-1\nan\tO\nenvironment\tO\nsuch\tO\nas\tO\nthe\tO\nemergency\tO\ndepartment\tO\n,\tO\nwhere\tO\nproper\tO\none\tO\n-\tO\non\tO\n-\tO\none\tO\nmonitoring\tO\nis\tO\nused\tO\nand\tO\nboard\tO\n-\tO\ncertified\tO\nphysicians\tO\nskilled\tO\nin\tO\nairway\tO\nmanagement\tO\nare\tO\ndirectly\tO\ninvolved\tT-2\nin\tO\nthe\tO\ncare\tO\nof\tO\nthe\tO\npatient\tO\n.\tO\n\nCyclosporine\tB-Chemical\nand\tO\ntacrolimus\tO\n-\tO\nassociated\tT-0\nthrombotic\tO\nmicroangiopathy\tO\n.\tO\n\nCyclosporine\tO\nand\tT-1\ntacrolimus\tB-Chemical\n-\tO\nassociated\tT-0\nthrombotic\tO\nmicroangiopathy\tO\n.\tO\n\nCyclosporine\tO\nand\tO\ntacrolimus\tO\n-\tT-1\nassociated\tT-1\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n.\tO\n\nThe\tO\ndevelopment\tT-2\nof\tT-2\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n(\tO\nTMA\tO\n)\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tT-1\nof\tT-1\ncyclosporine\tO\nhas\tO\nbeen\tO\nwell\tO\ndocumented\tT-0\n.\tO\n\nThe\tO\ndevelopment\tT-0\nof\tT-0\nthrombotic\tO\nmicroangiopathy\tO\n(\tO\nTMA\tB-Disease\n)\tO\nassociated\tT-1\nwith\tT-1\nthe\tO\nuse\tO\nof\tO\ncyclosporine\tO\nhas\tO\nbeen\tO\nwell\tO\ndocumented\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nthrombotic\tO\nmicroangiopathy\tO\n(\tO\nTMA\tO\n)\tO\nassociated\tT-1\nwith\tT-1\nthe\tT-1\nuse\tT-1\nof\tT-1\ncyclosporine\tB-Chemical\nhas\tO\nbeen\tO\nwell\tO\ndocumented\tO\n.\tO\n\nTreatments\tO\nhave\tO\nincluded\tO\ndiscontinuation\tO\nor\tO\nreduction\tT-1\nof\tT-1\ncyclosporine\tB-Chemical\ndose\tT-2\nwith\tO\nor\tO\nwithout\tO\nconcurrent\tO\nplasma\tO\nexchange\tT-0\n,\tO\nplasma\tO\ninfusion\tO\n,\tO\nanticoagulation\tO\n,\tO\nand\tO\nintravenous\tO\nimmunoglobulin\tO\nG\tO\ninfusion\tO\n.\tO\n\nThe\tO\nlast\tO\ndecade\tO\nhas\tO\nseen\tO\nthe\tO\nemergence\tT-0\nof\tT-0\ntacrolimus\tB-Chemical\nas\tT-1\na\tT-1\npotent\tT-1\nimmunosuppressive\tO\nagent\tO\nwith\tO\nmechanisms\tO\nof\tO\naction\tO\nvirtually\tO\nidentical\tO\nto\tO\nthose\tO\nof\tO\ncyclosporine\tO\n.\tO\n\nThe\tO\nlast\tO\ndecade\tO\nhas\tO\nseen\tO\nthe\tO\nemergence\tO\nof\tO\ntacrolimus\tO\nas\tO\na\tO\npotent\tO\nimmunosuppressive\tO\nagent\tO\nwith\tO\nmechanisms\tO\nof\tO\naction\tO\nvirtually\tT-0\nidentical\tT-0\nto\tT-0\nthose\tO\nof\tO\ncyclosporine\tB-Chemical\n.\tO\n\nAs\tO\na\tO\nresult\tO\n,\tO\nswitching\tT-0\nto\tT-0\ntacrolimus\tB-Chemical\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nbe\tO\na\tO\nviable\tO\ntherapeutic\tO\noption\tO\nin\tO\nthe\tO\nsetting\tO\nof\tO\ncyclosporine\tO\n-\tO\ninduced\tO\nTMA\tO\n.\tO\n\nAs\tO\na\tO\nresult\tO\n,\tO\nswitching\tO\nto\tO\ntacrolimus\tO\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nbe\tO\na\tO\nviable\tO\ntherapeutic\tO\noption\tO\nin\tO\nthe\tT-2\nsetting\tT-2\nof\tT-2\ncyclosporine\tB-Chemical\n-\tO\ninduced\tT-1\nTMA\tO\n.\tO\n\nAs\tO\na\tO\nresult\tO\n,\tO\nswitching\tO\nto\tO\ntacrolimus\tO\nhas\tO\nbeen\tO\nreported\tO\nto\tO\nbe\tO\na\tO\nviable\tO\ntherapeutic\tT-0\noption\tT-0\nin\tO\nthe\tO\nsetting\tO\nof\tO\ncyclosporine\tT-2\n-\tT-2\ninduced\tT-2\nTMA\tB-Disease\n.\tO\n\nWith\tO\nthe\tO\nmore\tO\nwidespread\tO\napplication\tT-1\nof\tT-1\ntacrolimus\tB-Chemical\nin\tO\norgan\tO\ntransplantation\tO\n,\tO\ntacrolimus\tO\n-\tO\nassociated\tT-0\nTMA\tO\nhas\tO\nalso\tO\nbeen\tO\nrecognized\tO\n.\tO\n\nWith\tO\nthe\tO\nmore\tO\nwidespread\tO\napplication\tT-0\nof\tT-0\ntacrolimus\tO\nin\tO\norgan\tO\ntransplantation\tO\n,\tO\ntacrolimus\tB-Chemical\n-\tO\nassociated\tT-1\nTMA\tO\nhas\tO\nalso\tO\nbeen\tO\nrecognized\tT-2\n.\tT-2\n\nWith\tO\nthe\tO\nmore\tO\nwidespread\tO\napplication\tT-0\nof\tT-0\ntacrolimus\tO\nin\tO\norgan\tO\ntransplantation\tO\n,\tO\ntacrolimus\tO\n-\tO\nassociated\tT-1\nTMA\tB-Disease\nhas\tT-2\nalso\tT-2\nbeen\tO\nrecognized\tO\n.\tO\n\nHowever\tO\n,\tO\nliterature\tO\nregarding\tO\nthe\tO\nincidence\tO\nof\tO\nthe\tO\nrecurrence\tT-0\nof\tT-0\nTMA\tB-Disease\nin\tT-1\npatients\tT-1\nexposed\tO\nsequentially\tO\nto\tO\ncyclosporine\tO\nand\tO\ntacrolimus\tO\nis\tO\nlimited\tO\n.\tO\n\nHowever\tO\n,\tO\nliterature\tO\nregarding\tO\nthe\tO\nincidence\tO\nof\tO\nthe\tO\nrecurrence\tT-0\nof\tT-0\nTMA\tT-0\nin\tO\npatients\tO\nexposed\tT-1\nsequentially\tT-1\nto\tT-1\ncyclosporine\tB-Chemical\nand\tO\ntacrolimus\tO\nis\tO\nlimited\tO\n.\tO\n\nHowever\tO\n,\tO\nliterature\tO\nregarding\tO\nthe\tO\nincidence\tO\nof\tO\nthe\tO\nrecurrence\tO\nof\tO\nTMA\tO\nin\tO\npatients\tO\nexposed\tO\nsequentially\tO\nto\tO\ncyclosporine\tO\nand\tT-0\ntacrolimus\tB-Chemical\nis\tT-1\nlimited\tT-1\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\nliving\tO\ndonor\tO\nrenal\tO\ntransplant\tO\nrecipient\tO\nwho\tT-2\ndeveloped\tT-2\ncyclosporine\tB-Chemical\n-\tO\ninduced\tO\nTMA\tO\nthat\tO\nresponded\tO\nto\tO\nthe\tO\nwithdrawal\tT-1\nof\tO\ncyclosporine\tO\nin\tO\nconjunction\tO\nwith\tO\nplasmapheresis\tO\nand\tO\nfresh\tO\nfrozen\tO\nplasma\tO\nreplacement\tO\ntherapy\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\nliving\tO\ndonor\tO\nrenal\tO\ntransplant\tO\nrecipient\tO\nwho\tO\ndeveloped\tO\ncyclosporine\tO\n-\tO\ninduced\tT-0\nTMA\tB-Disease\nthat\tO\nresponded\tT-1\nto\tO\nthe\tO\nwithdrawal\tO\nof\tO\ncyclosporine\tO\nin\tO\nconjunction\tO\nwith\tO\nplasmapheresis\tO\nand\tO\nfresh\tO\nfrozen\tO\nplasma\tO\nreplacement\tO\ntherapy\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\nliving\tO\ndonor\tO\nrenal\tO\ntransplant\tO\nrecipient\tO\nwho\tO\ndeveloped\tO\ncyclosporine\tO\n-\tO\ninduced\tT-0\nTMA\tO\nthat\tO\nresponded\tT-1\nto\tO\nthe\tO\nwithdrawal\tT-3\nof\tT-3\ncyclosporine\tB-Chemical\nin\tO\nconjunction\tO\nwith\tO\nplasmapheresis\tO\nand\tO\nfresh\tO\nfrozen\tO\nplasma\tO\nreplacement\tO\ntherapy\tO\n.\tO\n\nIntroduction\tT-0\nof\tT-0\ntacrolimus\tB-Chemical\nas\tT-1\nan\tT-1\nalternative\tT-1\nimmunosuppressive\tO\nagent\tO\nresulted\tO\nin\tO\nthe\tO\nrecurrence\tO\nof\tO\nTMA\tO\nand\tO\nthe\tO\nsubsequent\tO\nloss\tO\nof\tO\nthe\tO\nrenal\tO\nallograft\tO\n.\tO\n\nIntroduction\tO\nof\tO\ntacrolimus\tO\nas\tO\nan\tO\nalternative\tO\nimmunosuppressive\tO\nagent\tO\nresulted\tO\nin\tO\nthe\tO\nrecurrence\tT-1\nof\tO\nTMA\tB-Disease\nand\tO\nthe\tO\nsubsequent\tO\nloss\tO\nof\tO\nthe\tO\nrenal\tO\nallograft\tO\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\nswitched\tO\nfrom\tO\ncyclosporine\tB-Chemical\nto\tO\ntacrolimus\tO\nor\tO\nvice\tO\nversa\tO\nshould\tO\nbe\tO\nclosely\tO\nmonitored\tO\nfor\tO\nthe\tO\nsigns\tO\nand\tO\nsymptoms\tO\nof\tO\nrecurrent\tT-0\nTMA\tO\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\nswitched\tT-0\nfrom\tO\ncyclosporine\tO\nto\tT-1\ntacrolimus\tB-Chemical\nor\tO\nvice\tO\nversa\tO\nshould\tO\nbe\tO\nclosely\tO\nmonitored\tT-2\nfor\tO\nthe\tO\nsigns\tO\nand\tO\nsymptoms\tO\nof\tO\nrecurrent\tO\nTMA\tO\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\nswitched\tO\nfrom\tO\ncyclosporine\tO\nto\tO\ntacrolimus\tO\nor\tO\nvice\tO\nversa\tO\nshould\tO\nbe\tO\nclosely\tO\nmonitored\tO\nfor\tO\nthe\tO\nsigns\tT-0\nand\tT-0\nsymptoms\tT-0\nof\tO\nrecurrent\tT-1\nTMA\tB-Disease\n.\tO\n\nAnalgesic\tO\neffect\tT-0\nof\tT-0\nintravenous\tT-0\nketamine\tB-Chemical\nin\tT-1\ncancer\tT-1\npatients\tO\non\tO\nmorphine\tO\ntherapy\tO\n:\tO\na\tO\nrandomized\tO\n,\tO\ncontrolled\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nAnalgesic\tO\neffect\tT-0\nof\tT-0\nintravenous\tO\nketamine\tO\nin\tO\ncancer\tB-Disease\npatients\tT-1\non\tO\nmorphine\tO\ntherapy\tO\n:\tO\na\tO\nrandomized\tO\n,\tO\ncontrolled\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nAnalgesic\tO\neffect\tO\nof\tO\nintravenous\tO\nketamine\tO\nin\tO\ncancer\tO\npatients\tT-0\non\tT-0\nmorphine\tB-Chemical\ntherapy\tT-1\n:\tO\na\tO\nrandomized\tO\n,\tO\ncontrolled\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nPain\tB-Disease\nnot\tT-1\nresponsive\tT-1\nto\tT-1\nmorphine\tO\nis\tO\noften\tO\nproblematic\tO\n.\tO\n\nPain\tO\nnot\tT-1\nresponsive\tT-1\nto\tT-1\nmorphine\tB-Chemical\nis\tO\noften\tO\nproblematic\tO\n.\tO\n\nAnimal\tO\nand\tO\nclinical\tO\nstudies\tT-1\nhave\tO\nsuggested\tT-2\nthat\tT-2\nN\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\nD\tI-Chemical\n-\tI-Chemical\naspartate\tI-Chemical\n(\tO\nNMDA\tO\n)\tO\nantagonists\tO\n,\tO\nsuch\tO\nas\tO\nketamine\tO\n,\tO\nmay\tO\nbe\tO\neffective\tO\nin\tO\nimproving\tO\nopioid\tO\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tO\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tO\npain\tO\n.\tO\n\nAnimal\tO\nand\tO\nclinical\tO\nstudies\tO\nhave\tO\nsuggested\tO\nthat\tO\nN\tO\n-\tO\nmethyl\tO\n-\tO\nD\tO\n-\tO\naspartate\tO\n(\tO\nNMDA\tB-Chemical\n)\tO\nantagonists\tT-0\n,\tO\nsuch\tO\nas\tO\nketamine\tO\n,\tO\nmay\tO\nbe\tO\neffective\tO\nin\tO\nimproving\tT-1\nopioid\tO\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tO\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tO\npain\tO\n.\tO\n\nAnimal\tO\nand\tO\nclinical\tO\nstudies\tO\nhave\tO\nsuggested\tO\nthat\tO\nN\tO\n-\tO\nmethyl\tO\n-\tO\nD\tO\n-\tO\naspartate\tO\n(\tO\nNMDA\tO\n)\tO\nantagonists\tO\n,\tO\nsuch\tT-1\nas\tT-1\nketamine\tB-Chemical\n,\tT-0\nmay\tT-0\nbe\tT-0\neffective\tT-0\nin\tO\nimproving\tO\nopioid\tO\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tO\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tO\npain\tO\n.\tO\n\nAnimal\tT-2\nand\tT-2\nclinical\tT-2\nstudies\tT-2\nhave\tO\nsuggested\tO\nthat\tO\nN\tO\n-\tO\nmethyl\tO\n-\tO\nD\tO\n-\tO\naspartate\tO\n(\tO\nNMDA\tO\n)\tO\nantagonists\tO\n,\tO\nsuch\tO\nas\tO\nketamine\tO\n,\tO\nmay\tO\nbe\tO\neffective\tT-3\nin\tT-3\nimproving\tT-3\nopioid\tO\nanalgesia\tO\nin\tT-1\ndifficult\tO\npain\tB-Disease\nsyndromes\tT-0\n,\tO\nsuch\tO\nas\tO\nneuropathic\tO\npain\tO\n.\tO\n\nAnimal\tO\nand\tO\nclinical\tO\nstudies\tO\nhave\tO\nsuggested\tO\nthat\tO\nN\tO\n-\tO\nmethyl\tO\n-\tO\nD\tO\n-\tO\naspartate\tO\n(\tO\nNMDA\tO\n)\tO\nantagonists\tO\n,\tO\nsuch\tO\nas\tO\nketamine\tO\n,\tO\nmay\tT-0\nbe\tT-0\neffective\tT-0\nin\tT-0\nimproving\tO\nopioid\tO\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tO\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tB-Disease\npain\tI-Disease\n.\tO\n\nA\tO\nslow\tO\nbolus\tO\nof\tO\nsubhypnotic\tO\ndoses\tO\nof\tO\nketamine\tB-Chemical\n(\tO\n0\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nor\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ngiven\tT-0\nto\tT-0\n10\tO\ncancer\tO\npatients\tO\nwhose\tO\npain\tO\nwas\tO\nunrelieved\tO\nby\tO\nmorphine\tO\nin\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nA\tO\nslow\tO\nbolus\tO\nof\tO\nsubhypnotic\tO\ndoses\tO\nof\tO\nketamine\tO\n(\tO\n0\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nor\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ngiven\tO\nto\tO\n10\tO\ncancer\tB-Disease\npatients\tT-0\nwhose\tO\npain\tO\nwas\tO\nunrelieved\tO\nby\tO\nmorphine\tO\nin\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nA\tO\nslow\tO\nbolus\tO\nof\tO\nsubhypnotic\tO\ndoses\tO\nof\tO\nketamine\tO\n(\tO\n0\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nor\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ngiven\tO\nto\tO\n10\tO\ncancer\tO\npatients\tT-2\nwhose\tT-2\npain\tB-Disease\nwas\tT-1\nunrelieved\tT-1\nby\tO\nmorphine\tO\nin\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nA\tO\nslow\tO\nbolus\tO\nof\tO\nsubhypnotic\tO\ndoses\tO\nof\tO\nketamine\tO\n(\tO\n0\tO\n.\tO\n25\tO\nmg\tO\n/\tO\nkg\tO\nor\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nwas\tO\ngiven\tT-1\nto\tT-1\n10\tO\ncancer\tO\npatients\tO\nwhose\tO\npain\tO\nwas\tO\nunrelieved\tT-0\nby\tT-0\nmorphine\tB-Chemical\nin\tO\na\tO\nrandomized\tO\n,\tO\ndouble\tO\n-\tO\nblind\tO\n,\tO\ncrossover\tO\n,\tO\ndouble\tO\n-\tO\ndose\tO\nstudy\tO\n.\tO\n\nPain\tB-Disease\nintensity\tO\non\tO\na\tO\n0\tO\nto\tO\n10\tO\nnumerical\tT-1\nscale\tT-1\n;\tO\nnausea\tO\nand\tO\nvomiting\tO\n,\tO\ndrowsiness\tO\n,\tO\nconfusion\tO\n,\tO\nand\tO\ndry\tO\nmouth\tO\n,\tO\nusing\tO\na\tO\nscale\tO\nfrom\tO\n0\tO\nto\tO\n3\tO\n(\tO\nnot\tO\nat\tO\nall\tO\n,\tO\nslight\tO\n,\tO\na\tO\nlot\tO\n,\tO\nawful\tO\n)\tO\n;\tO\nMini\tO\n-\tO\nMental\tO\nState\tO\nExamination\tO\n(\tO\nMMSE\tO\n)\tO\n(\tO\n0\tO\n-\tO\n30\tO\n)\tO\n;\tO\nand\tO\narterial\tO\npressure\tO\nwere\tO\nrecorded\tO\nbefore\tO\nadministration\tT-2\nof\tT-2\ndrugs\tT-2\n(\tO\nT0\tO\n)\tO\nand\tO\nafter\tO\n30\tO\nminutes\tO\n(\tO\nT30\tO\n)\tO\n,\tO\n60\tO\nminutes\tO\n(\tO\nT60\tO\n)\tO\n,\tO\n120\tO\nminutes\tO\n(\tO\nT120\tO\n)\tO\n,\tO\nand\tO\n180\tO\nminutes\tO\n(\tO\nT180\tO\n)\tO\n.\tO\n\nPain\tO\nintensity\tO\non\tO\na\tO\n0\tO\nto\tO\n10\tO\nnumerical\tO\nscale\tO\n;\tO\nnausea\tB-Disease\nand\tO\nvomiting\tO\n,\tO\ndrowsiness\tO\n,\tO\nconfusion\tO\n,\tO\nand\tO\ndry\tO\nmouth\tO\n,\tO\nusing\tO\na\tO\nscale\tO\nfrom\tO\n0\tO\nto\tO\n3\tO\n(\tO\nnot\tO\nat\tO\nall\tO\n,\tO\nslight\tO\n,\tO\na\tO\nlot\tO\n,\tO\nawful\tO\n)\tO\n;\tO\nMini\tO\n-\tO\nMental\tO\nState\tO\nExamination\tO\n(\tO\nMMSE\tO\n)\tO\n(\tO\n0\tO\n-\tO\n30\tO\n)\tO\n;\tO\nand\tO\narterial\tO\npressure\tO\nwere\tO\nrecorded\tO\nbefore\tO\nadministration\tT-0\nof\tO\ndrugs\tO\n(\tO\nT0\tO\n)\tO\nand\tO\nafter\tO\n30\tO\nminutes\tO\n(\tO\nT30\tO\n)\tO\n,\tO\n60\tO\nminutes\tO\n(\tO\nT60\tO\n)\tO\n,\tO\n120\tO\nminutes\tO\n(\tO\nT120\tO\n)\tO\n,\tO\nand\tO\n180\tO\nminutes\tO\n(\tO\nT180\tO\n)\tO\n.\tO\n\nPain\tO\nintensity\tO\non\tO\na\tO\n0\tO\nto\tO\n10\tO\nnumerical\tO\nscale\tO\n;\tO\nnausea\tO\nand\tO\nvomiting\tB-Disease\n,\tO\ndrowsiness\tO\n,\tO\nconfusion\tO\n,\tO\nand\tO\ndry\tO\nmouth\tO\n,\tO\nusing\tO\na\tO\nscale\tO\nfrom\tO\n0\tO\nto\tO\n3\tO\n(\tO\nnot\tO\nat\tO\nall\tO\n,\tO\nslight\tO\n,\tO\na\tO\nlot\tO\n,\tO\nawful\tO\n)\tO\n;\tO\nMini\tO\n-\tO\nMental\tO\nState\tO\nExamination\tO\n(\tO\nMMSE\tO\n)\tO\n(\tO\n0\tO\n-\tO\n30\tO\n)\tO\n;\tO\nand\tO\narterial\tO\npressure\tO\nwere\tO\nrecorded\tO\nbefore\tO\nadministration\tT-0\nof\tT-0\ndrugs\tO\n(\tO\nT0\tO\n)\tO\nand\tO\nafter\tO\n30\tO\nminutes\tO\n(\tO\nT30\tO\n)\tO\n,\tO\n60\tO\nminutes\tO\n(\tO\nT60\tO\n)\tO\n,\tO\n120\tO\nminutes\tO\n(\tO\nT120\tO\n)\tO\n,\tO\nand\tO\n180\tO\nminutes\tO\n(\tO\nT180\tO\n)\tO\n.\tO\n\nPain\tT-2\nintensity\tT-2\non\tO\na\tO\n0\tO\nto\tO\n10\tO\nnumerical\tO\nscale\tO\n;\tO\nnausea\tO\nand\tO\nvomiting\tO\n,\tO\ndrowsiness\tT-0\n,\tT-0\nconfusion\tB-Disease\n,\tT-1\nand\tT-1\ndry\tT-1\nmouth\tT-1\n,\tO\nusing\tO\na\tO\nscale\tO\nfrom\tO\n0\tO\nto\tO\n3\tO\n(\tO\nnot\tO\nat\tO\nall\tO\n,\tO\nslight\tO\n,\tO\na\tO\nlot\tO\n,\tO\nawful\tO\n)\tO\n;\tO\nMini\tO\n-\tO\nMental\tO\nState\tO\nExamination\tO\n(\tO\nMMSE\tO\n)\tO\n(\tO\n0\tO\n-\tO\n30\tO\n)\tO\n;\tO\nand\tO\narterial\tO\npressure\tO\nwere\tO\nrecorded\tO\nbefore\tO\nadministration\tO\nof\tO\ndrugs\tO\n(\tO\nT0\tO\n)\tO\nand\tO\nafter\tO\n30\tO\nminutes\tO\n(\tO\nT30\tO\n)\tO\n,\tO\n60\tO\nminutes\tO\n(\tO\nT60\tO\n)\tO\n,\tO\n120\tO\nminutes\tO\n(\tO\nT120\tO\n)\tO\n,\tO\nand\tO\n180\tO\nminutes\tO\n(\tO\nT180\tO\n)\tO\n.\tO\n\nPain\tO\nintensity\tO\non\tO\na\tO\n0\tO\nto\tO\n10\tO\nnumerical\tO\nscale\tO\n;\tO\nnausea\tO\nand\tO\nvomiting\tO\n,\tO\ndrowsiness\tO\n,\tO\nconfusion\tO\n,\tO\nand\tT-1\ndry\tB-Disease\nmouth\tI-Disease\n,\tO\nusing\tO\na\tO\nscale\tO\nfrom\tO\n0\tO\nto\tO\n3\tO\n(\tO\nnot\tO\nat\tO\nall\tO\n,\tO\nslight\tO\n,\tO\na\tO\nlot\tO\n,\tO\nawful\tO\n)\tO\n;\tO\nMini\tO\n-\tO\nMental\tO\nState\tO\nExamination\tO\n(\tO\nMMSE\tO\n)\tO\n(\tO\n0\tO\n-\tO\n30\tO\n)\tO\n;\tO\nand\tO\narterial\tO\npressure\tO\nwere\tO\nrecorded\tO\nbefore\tO\nadministration\tO\nof\tO\ndrugs\tO\n(\tO\nT0\tO\n)\tO\nand\tO\nafter\tO\n30\tO\nminutes\tO\n(\tO\nT30\tO\n)\tO\n,\tO\n60\tO\nminutes\tO\n(\tO\nT60\tO\n)\tO\n,\tO\n120\tO\nminutes\tO\n(\tO\nT120\tO\n)\tO\n,\tO\nand\tO\n180\tO\nminutes\tO\n(\tO\nT180\tO\n)\tO\n.\tT-0\n\nKetamine\tB-Chemical\n,\tO\nbut\tT-0\nnot\tT-0\nsaline\tO\nsolution\tO\n,\tO\nsignificantly\tT-1\nreduced\tT-1\nthe\tO\npain\tO\nintensity\tO\nin\tO\nalmost\tO\nall\tO\nthe\tO\npatients\tO\nat\tO\nboth\tO\ndoses\tO\n.\tO\n\nKetamine\tO\n,\tO\nbut\tO\nnot\tO\nsaline\tO\nsolution\tO\n,\tO\nsignificantly\tO\nreduced\tT-1\nthe\tT-1\npain\tB-Disease\nintensity\tT-2\nin\tT-2\nalmost\tT-2\nall\tT-2\nthe\tT-2\npatients\tT-2\nat\tO\nboth\tO\ndoses\tO\n.\tO\n\nHallucinations\tB-Disease\noccurred\tT-1\nin\tT-1\n4\tO\npatients\tO\n,\tO\nand\tO\nan\tO\nunpleasant\tO\nsensation\tO\n(\tO\n\"\tO\nempty\tO\nhead\tO\n\"\tO\n)\tO\nwas\tO\nalso\tO\nreported\tO\nby\tO\n2\tO\npatients\tO\n.\tO\n\nThese\tO\nepisodes\tO\nreversed\tT-0\nafter\tO\nthe\tO\nadministration\tT-2\nof\tT-2\ndiazepam\tB-Chemical\n1\tO\nmg\tO\nintravenously\tT-1\n.\tO\n\nSignificant\tO\nincreases\tO\nin\tO\ndrowsiness\tO\nwere\tO\nreported\tO\nin\tO\npatients\tO\ntreated\tT-0\nwith\tT-0\nketamine\tB-Chemical\nin\tO\nboth\tO\ngroups\tO\nand\tO\nwere\tO\nmore\tO\nmarked\tO\nwith\tO\nketamine\tO\n0\tO\n.\tO\n50\tO\nmg\tO\n/\tO\nkg\tO\n.\tO\n\nSignificant\tO\nincreases\tO\nin\tO\ndrowsiness\tO\nwere\tO\nreported\tO\nin\tO\npatients\tO\ntreated\tO\nwith\tO\nketamine\tO\nin\tO\nboth\tO\ngroups\tO\nand\tO\nwere\tO\nmore\tO\nmarked\tT-1\nwith\tT-1\nketamine\tB-Chemical\n0\tT-0\n.\tT-0\n50\tT-0\nmg\tT-0\n/\tT-0\nkg\tT-0\n.\tO\n\nA\tO\nsignificant\tO\ndifference\tO\nin\tO\nMMSE\tO\nwas\tO\nobserved\tT-2\nat\tO\nT30\tO\nin\tO\npatients\tT-0\nwho\tT-0\nreceived\tT-0\n0\tO\n.\tO\n50\tT-1\nmg\tT-1\n/\tT-1\nkg\tT-1\nof\tT-1\nketamine\tB-Chemical\n.\tO\n\nKetamine\tB-Chemical\ncan\tT-0\nimprove\tT-0\nmorphine\tO\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tO\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tO\npain\tO\n.\tO\n\nKetamine\tO\ncan\tO\nimprove\tT-1\nmorphine\tB-Chemical\nanalgesia\tT-0\nin\tO\ndifficult\tO\npain\tO\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tO\npain\tO\n.\tO\n\nKetamine\tO\ncan\tO\nimprove\tT-1\nmorphine\tO\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tB-Disease\nsyndromes\tT-0\n,\tO\nsuch\tO\nas\tO\nneuropathic\tO\npain\tO\n.\tO\n\nKetamine\tO\ncan\tT-0\nimprove\tT-0\nmorphine\tO\nanalgesia\tO\nin\tO\ndifficult\tO\npain\tO\nsyndromes\tO\n,\tO\nsuch\tO\nas\tO\nneuropathic\tB-Disease\npain\tI-Disease\n.\tO\n\nThis\tO\nobservation\tT-0\nshould\tO\nbe\tO\ntested\tO\nin\tO\nstudies\tT-1\nof\tO\nprolonged\tT-2\nketamine\tB-Chemical\nadministration\tT-3\n.\tO\n\nPaclitaxel\tB-Chemical\n,\tT-1\ncisplatin\tT-1\n,\tO\nand\tO\ngemcitabine\tO\ncombination\tO\nchemotherapy\tO\nwithin\tO\na\tO\nmultidisciplinary\tO\ntherapeutic\tO\napproach\tT-0\nin\tO\nmetastatic\tO\nnonsmall\tO\ncell\tO\nlung\tO\ncarcinoma\tO\n.\tO\n\nPaclitaxel\tO\n,\tO\ncisplatin\tB-Chemical\n,\tO\nand\tO\ngemcitabine\tO\ncombination\tO\nchemotherapy\tO\nwithin\tO\na\tO\nmultidisciplinary\tO\ntherapeutic\tO\napproach\tT-0\nin\tO\nmetastatic\tO\nnonsmall\tO\ncell\tO\nlung\tO\ncarcinoma\tO\n.\tO\n\nPaclitaxel\tT-0\n,\tO\ncisplatin\tT-1\n,\tO\nand\tO\ngemcitabine\tB-Chemical\ncombination\tO\nchemotherapy\tT-2\nwithin\tO\na\tO\nmultidisciplinary\tO\ntherapeutic\tO\napproach\tO\nin\tO\nmetastatic\tO\nnonsmall\tO\ncell\tO\nlung\tO\ncarcinoma\tO\n.\tO\n\nPaclitaxel\tO\n,\tO\ncisplatin\tO\n,\tO\nand\tO\ngemcitabine\tO\ncombination\tO\nchemotherapy\tO\nwithin\tO\na\tO\nmultidisciplinary\tO\ntherapeutic\tO\napproach\tT-0\nin\tO\nmetastatic\tT-1\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nCisplatin\tB-Chemical\n-\tO\nbased\tT-1\nchemotherapy\tT-1\ncombinations\tO\nimprove\tT-0\nquality\tO\nof\tO\nlife\tO\nand\tO\nsurvival\tO\nin\tO\nadvanced\tO\nnonsmall\tO\ncell\tO\nlung\tO\ncarcinoma\tO\n(\tO\nNSCLC\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCisplatin\tO\n-\tO\nbased\tO\nchemotherapy\tT-2\ncombinations\tO\nimprove\tT-1\nquality\tO\nof\tO\nlife\tO\nand\tO\nsurvival\tO\nin\tT-0\nadvanced\tO\nnonsmall\tB-Disease\ncell\tI-Disease\nlung\tI-Disease\ncarcinoma\tI-Disease\n(\tO\nNSCLC\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCisplatin\tO\n-\tO\nbased\tO\nchemotherapy\tO\ncombinations\tO\nimprove\tT-1\nquality\tO\nof\tO\nlife\tO\nand\tO\nsurvival\tO\nin\tO\nadvanced\tO\nnonsmall\tO\ncell\tO\nlung\tT-0\ncarcinoma\tT-0\n(\tO\nNSCLC\tB-Disease\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\nfeasibility\tO\n,\tO\nresponse\tO\nrate\tO\n,\tO\nand\tO\ntoxicity\tB-Disease\nof\tO\na\tO\npaclitaxel\tO\n,\tO\ncisplatin\tO\n,\tO\nand\tO\ngemcitabine\tO\ncombination\tT-1\nto\tO\ntreat\tT-0\nmetastatic\tO\nNSCLC\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tT-1\nthe\tO\nfeasibility\tO\n,\tO\nresponse\tO\nrate\tO\n,\tO\nand\tO\ntoxicity\tT-2\nof\tT-2\na\tT-2\npaclitaxel\tB-Chemical\n,\tO\ncisplatin\tO\n,\tO\nand\tO\ngemcitabine\tO\ncombination\tT-3\nto\tO\ntreat\tO\nmetastatic\tO\nNSCLC\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tT-2\ndetermine\tT-2\nthe\tO\nfeasibility\tO\n,\tO\nresponse\tO\nrate\tO\n,\tO\nand\tO\ntoxicity\tO\nof\tO\na\tO\npaclitaxel\tO\n,\tO\ncisplatin\tB-Chemical\n,\tO\nand\tO\ngemcitabine\tO\ncombination\tO\nto\tT-1\ntreat\tT-1\nmetastatic\tO\nNSCLC\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tT-0\nthe\tO\nfeasibility\tO\n,\tO\nresponse\tO\nrate\tO\n,\tO\nand\tO\ntoxicity\tO\nof\tO\na\tO\npaclitaxel\tO\n,\tO\ncisplatin\tT-1\n,\tT-1\nand\tT-1\ngemcitabine\tB-Chemical\ncombination\tT-2\nto\tO\ntreat\tO\nmetastatic\tO\nNSCLC\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThe\tO\nobjective\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nthe\tO\nfeasibility\tO\n,\tO\nresponse\tO\nrate\tO\n,\tO\nand\tO\ntoxicity\tO\nof\tO\na\tO\npaclitaxel\tO\n,\tO\ncisplatin\tO\n,\tO\nand\tO\ngemcitabine\tO\ncombination\tO\nto\tT-1\ntreat\tT-1\nmetastatic\tT-1\nNSCLC\tB-Disease\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\nconsecutive\tO\nchemotherapy\tO\n-\tO\nnaive\tO\npatients\tO\nwith\tO\nStage\tT-1\nIV\tT-1\nNSCLC\tB-Disease\nand\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nperformance\tO\nstatus\tO\nof\tO\n0\tO\n-\tO\n2\tO\nwere\tO\ntreated\tT-0\nwith\tT-0\na\tO\ncombination\tO\nof\tO\npaclitaxel\tO\n(\tO\n135\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n3\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\ncisplatin\tO\n(\tO\n120\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n6\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\nand\tO\ngemcitabine\tO\n(\tO\n800\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n30\tO\nminutes\tO\n)\tO\non\tO\nDays\tO\n1\tO\nand\tO\n8\tO\n,\tO\nevery\tO\n4\tO\nweeks\tO\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\nconsecutive\tO\nchemotherapy\tO\n-\tO\nnaive\tO\npatients\tO\nwith\tO\nStage\tO\nIV\tO\nNSCLC\tO\nand\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nperformance\tO\nstatus\tO\nof\tO\n0\tO\n-\tO\n2\tO\nwere\tO\ntreated\tO\nwith\tO\na\tO\ncombination\tT-1\nof\tT-1\npaclitaxel\tB-Chemical\n(\tO\n135\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tT-0\nintravenously\tT-0\nin\tO\n3\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\ncisplatin\tO\n(\tO\n120\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n6\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\nand\tO\ngemcitabine\tO\n(\tO\n800\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n30\tO\nminutes\tO\n)\tO\non\tO\nDays\tO\n1\tO\nand\tO\n8\tO\n,\tO\nevery\tO\n4\tO\nweeks\tO\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\nconsecutive\tO\nchemotherapy\tO\n-\tO\nnaive\tO\npatients\tO\nwith\tO\nStage\tO\nIV\tO\nNSCLC\tO\nand\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nperformance\tO\nstatus\tO\nof\tO\n0\tO\n-\tO\n2\tO\nwere\tO\ntreated\tO\nwith\tO\na\tO\ncombination\tO\nof\tO\npaclitaxel\tO\n(\tO\n135\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n3\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\ncisplatin\tB-Chemical\n(\tT-1\n120\tT-1\nmg\tT-1\n/\tT-1\nm\tT-1\n(\tT-1\n2\tT-1\n)\tT-1\ngiven\tT-0\nintravenously\tT-0\nin\tO\n6\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\nand\tO\ngemcitabine\tO\n(\tO\n800\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n30\tO\nminutes\tO\n)\tO\non\tO\nDays\tO\n1\tO\nand\tO\n8\tO\n,\tO\nevery\tO\n4\tO\nweeks\tO\n.\tO\n\nThirty\tO\n-\tO\nfive\tO\nconsecutive\tO\nchemotherapy\tO\n-\tO\nnaive\tO\npatients\tO\nwith\tO\nStage\tO\nIV\tO\nNSCLC\tO\nand\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nperformance\tO\nstatus\tO\nof\tO\n0\tO\n-\tO\n2\tO\nwere\tO\ntreated\tT-2\nwith\tT-2\na\tO\ncombination\tO\nof\tO\npaclitaxel\tO\n(\tO\n135\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n3\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\ncisplatin\tO\n(\tO\n120\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\ngiven\tO\nintravenously\tO\nin\tO\n6\tO\nhours\tO\n)\tO\non\tO\nDay\tO\n1\tO\n,\tO\nand\tO\ngemcitabine\tB-Chemical\n(\tT-1\n800\tT-1\nmg\tT-1\n/\tT-1\nm\tT-1\n(\tT-1\n2\tT-1\n)\tT-1\ngiven\tT-0\nintravenously\tT-0\nin\tO\n30\tO\nminutes\tO\n)\tO\non\tO\nDays\tO\n1\tO\nand\tO\n8\tO\n,\tO\nevery\tO\n4\tO\nweeks\tO\n.\tO\n\nAlthough\tO\nresponding\tO\npatients\tO\nwere\tO\nscheduled\tO\nto\tT-0\nreceive\tT-0\nconsolidation\tO\nradiotherapy\tO\nand\tO\n24\tO\npatients\tO\nreceived\tO\npreplanned\tO\nsecond\tO\n-\tO\nline\tO\nchemotherapy\tO\nafter\tT-2\ndisease\tT-2\nprogression\tT-2\n,\tO\nthe\tT-3\nresponse\tT-3\nand\tO\ntoxicity\tB-Disease\nrates\tO\nreported\tO\nrefer\tO\nonly\tO\nto\tO\nthe\tO\nchemotherapy\tO\nregimen\tO\ngiven\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAll\tO\nthe\tO\npatients\tT-0\nwere\tO\nexamined\tT-1\nfor\tT-1\ntoxicity\tB-Disease\n;\tO\n34\tO\nwere\tO\nexaminable\tO\nfor\tO\nresponse\tO\n.\tO\n\nAfter\tO\n154\tO\ncourses\tT-1\nof\tT-1\ntherapy\tT-1\n,\tO\nthe\tO\nmedian\tT-2\ndose\tT-2\nintensity\tT-2\nwas\tO\n131\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tT-0\npaclitaxel\tB-Chemical\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\n117\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\ncisplatin\tO\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nand\tO\n1378\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\ngemcitabine\tO\n(\tO\n86\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nAfter\tO\n154\tO\ncourses\tO\nof\tO\ntherapy\tO\n,\tO\nthe\tO\nmedian\tO\ndose\tO\nintensity\tO\nwas\tO\n131\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\npaclitaxel\tO\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\n117\tT-0\nmg\tT-0\n/\tT-0\nm\tT-0\n(\tT-0\n2\tT-0\n)\tT-0\nfor\tO\ncisplatin\tB-Chemical\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nand\tO\n1378\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\ngemcitabine\tO\n(\tO\n86\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nAfter\tO\n154\tO\ncourses\tT-1\nof\tT-1\ntherapy\tT-1\n,\tO\nthe\tO\nmedian\tO\ndose\tT-0\nintensity\tT-0\nwas\tT-0\n131\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\npaclitaxel\tO\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\n117\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\nfor\tO\ncisplatin\tO\n(\tO\n97\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nand\tO\n1378\tT-2\nmg\tT-2\n/\tT-2\nm\tT-2\n(\tT-2\n2\tT-2\n)\tT-2\nfor\tT-2\ngemcitabine\tB-Chemical\n(\tO\n86\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nWorld\tO\nHealth\tO\nOrganization\tO\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tB-Disease\nand\tT-0\nthrombocytopenia\tO\noccurred\tT-1\nin\tT-1\n39\tO\n.\tO\n9\tO\n%\tO\nand\tO\n11\tO\n.\tO\n4\tO\n%\tO\nof\tO\npatients\tO\n,\tO\nrespectively\tO\n.\tO\n\nWorld\tT-1\nHealth\tT-1\nOrganization\tT-1\nGrade\tO\n3\tO\n-\tO\n4\tO\nneutropenia\tT-2\nand\tO\nthrombocytopenia\tB-Disease\noccurred\tT-0\nin\tO\n39\tO\n.\tO\n9\tO\n%\tO\nand\tO\n11\tO\n.\tO\n4\tO\n%\tO\nof\tO\npatients\tT-3\n,\tO\nrespectively\tO\n.\tO\n\nThere\tO\nwas\tO\none\tO\ntreatment\tT-0\n-\tT-0\nrelated\tT-1\ndeath\tB-Disease\n.\tO\n\nNonhematologic\tT-1\ntoxicities\tB-Disease\nwere\tT-0\nmild\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tT-0\nof\tT-0\npaclitaxel\tB-Chemical\n,\tO\ncisplatin\tO\n,\tO\nand\tO\ngemcitabine\tO\nis\tO\nwell\tT-1\ntolerated\tT-1\nand\tO\nshows\tO\nhigh\tT-2\nactivity\tT-2\nin\tO\nmetastatic\tO\nNSCLC\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tT-1\nof\tT-1\npaclitaxel\tO\n,\tO\ncisplatin\tB-Chemical\n,\tO\nand\tO\ngemcitabine\tO\nis\tO\nwell\tT-0\ntolerated\tT-0\nand\tO\nshows\tO\nhigh\tO\nactivity\tO\nin\tO\nmetastatic\tO\nNSCLC\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tT-2\nof\tT-2\npaclitaxel\tO\n,\tO\ncisplatin\tO\n,\tO\nand\tO\ngemcitabine\tB-Chemical\nis\tT-0\nwell\tT-0\ntolerated\tT-1\nand\tO\nshows\tO\nhigh\tO\nactivity\tO\nin\tO\nmetastatic\tO\nNSCLC\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tO\nof\tO\npaclitaxel\tO\n,\tO\ncisplatin\tO\n,\tO\nand\tO\ngemcitabine\tO\nis\tO\nwell\tO\ntolerated\tO\nand\tO\nshows\tT-2\nhigh\tO\nactivity\tO\nin\tT-0\nmetastatic\tT-1\nNSCLC\tB-Disease\n.\tO\n\nThis\tO\ntreatment\tO\nmerits\tT-0\nfurther\tO\ncomparison\tO\nwith\tO\nother\tO\ncisplatin\tB-Chemical\n-\tO\nbased\tO\nregimens\tO\n.\tO\n\nSerotonergic\tO\nantidepressants\tO\nand\tT-0\nurinary\tB-Disease\nincontinence\tI-Disease\n.\tO\n\nMany\tO\nnew\tO\nserotonergic\tB-Chemical\nantidepressants\tI-Chemical\nhave\tO\nbeen\tO\nintroduced\tT-0\nover\tO\nthe\tO\npast\tO\ndecade\tO\n.\tO\n\nAlthough\tO\nurinary\tB-Disease\nincontinence\tI-Disease\nis\tT-1\nlisted\tT-1\nas\tT-1\none\tO\nside\tO\neffect\tO\nof\tO\nthese\tO\ndrugs\tO\nin\tO\ntheir\tO\npackage\tO\ninserts\tO\nthere\tO\nis\tO\nonly\tO\none\tO\nreport\tO\nin\tO\nthe\tO\nliterature\tO\n.\tO\n\nThis\tO\nconcerns\tO\n2\tO\nmale\tO\npatients\tO\nwho\tO\nexperienced\tT-0\nincontinence\tB-Disease\nwhile\tO\ntaking\tO\nvenlafaxine\tO\n.\tO\n\nThis\tO\nconcerns\tO\n2\tO\nmale\tO\npatients\tO\nwho\tO\nexperienced\tT-0\nincontinence\tO\nwhile\tT-1\ntaking\tT-1\nvenlafaxine\tB-Chemical\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\npaper\tO\nthe\tO\nauthors\tO\ndescribe\tO\n2\tO\nfemale\tO\npatients\tO\nwho\tO\ndeveloped\tT-0\nincontinence\tB-Disease\nsecondary\tT-1\nto\tT-1\nthe\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\nparoxetine\tO\nand\tO\nsertraline\tO\n,\tO\nas\tO\nwell\tO\nas\tO\na\tO\nthird\tO\nwho\tO\ndeveloped\tO\nthis\tO\nside\tO\neffect\tO\non\tO\nvenlafaxine\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\npaper\tO\nthe\tO\nauthors\tO\ndescribe\tO\n2\tO\nfemale\tO\npatients\tO\nwho\tO\ndeveloped\tT-0\nincontinence\tT-0\nsecondary\tO\nto\tT-1\nthe\tT-1\nselective\tT-1\nserotonin\tB-Chemical\nreuptake\tO\ninhibitors\tO\nparoxetine\tO\nand\tO\nsertraline\tO\n,\tO\nas\tO\nwell\tO\nas\tO\na\tO\nthird\tO\nwho\tO\ndeveloped\tO\nthis\tO\nside\tO\neffect\tO\non\tO\nvenlafaxine\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\npaper\tO\nthe\tO\nauthors\tO\ndescribe\tO\n2\tO\nfemale\tO\npatients\tO\nwho\tT-0\ndeveloped\tT-0\nincontinence\tO\nsecondary\tO\nto\tO\nthe\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\nparoxetine\tB-Chemical\nand\tT-1\nsertraline\tO\n,\tO\nas\tO\nwell\tO\nas\tO\na\tO\nthird\tO\nwho\tO\ndeveloped\tO\nthis\tO\nside\tO\neffect\tO\non\tO\nvenlafaxine\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\npaper\tO\nthe\tO\nauthors\tO\ndescribe\tO\n2\tO\nfemale\tO\npatients\tO\nwho\tO\ndeveloped\tT-1\nincontinence\tO\nsecondary\tO\nto\tO\nthe\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\nparoxetine\tT-0\nand\tT-0\nsertraline\tB-Chemical\n,\tO\nas\tO\nwell\tO\nas\tO\na\tO\nthird\tO\nwho\tO\ndeveloped\tO\nthis\tO\nside\tT-2\neffect\tT-2\non\tO\nvenlafaxine\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\npaper\tO\nthe\tO\nauthors\tO\ndescribe\tO\n2\tO\nfemale\tO\npatients\tO\nwho\tO\ndeveloped\tO\nincontinence\tO\nsecondary\tO\nto\tO\nthe\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\nparoxetine\tO\nand\tO\nsertraline\tO\n,\tO\nas\tO\nwell\tO\nas\tO\na\tO\nthird\tO\nwho\tO\ndeveloped\tO\nthis\tO\nside\tT-1\neffect\tT-1\non\tT-1\nvenlafaxine\tB-Chemical\n.\tO\n\nIn\tO\n2\tO\nof\tO\nthe\tO\n3\tO\ncases\tO\nthe\tT-3\npatients\tT-3\nwere\tO\nalso\tO\ntaking\tT-1\nlithium\tB-Chemical\ncarbonate\tI-Chemical\nand\tT-2\nbeta\tO\n-\tO\nblockers\tO\n,\tO\nboth\tO\nof\tO\nwhich\tO\ncould\tO\nhave\tO\ncontributed\tT-0\nto\tO\nthe\tO\nincontinence\tO\n.\tO\n\nIn\tO\n2\tO\nof\tO\nthe\tO\n3\tO\ncases\tO\nthe\tO\npatients\tO\nwere\tO\nalso\tO\ntaking\tO\nlithium\tO\ncarbonate\tO\nand\tO\nbeta\tO\n-\tO\nblockers\tO\n,\tO\nboth\tO\nof\tO\nwhich\tO\ncould\tO\nhave\tO\ncontributed\tT-1\nto\tT-1\nthe\tT-1\nincontinence\tB-Disease\n.\tO\n\nAnimal\tO\nstudies\tO\nsuggest\tT-3\nthat\tT-3\nincontinence\tO\nsecondary\tT-0\nto\tT-0\nserotonergic\tB-Chemical\nantidepressants\tI-Chemical\ncould\tT-2\nbe\tT-2\nmediated\tT-1\nby\tT-1\nthe\tO\n5HT4\tO\nreceptors\tO\nfound\tO\non\tO\nthe\tO\nbladder\tO\n.\tO\n\nAcute\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tT-0\nseizures\tO\n:\tO\ndifferential\tO\nsensitivity\tO\nof\tO\nsix\tO\ninbred\tO\nmouse\tO\nstrains\tO\n.\tO\n\nAcute\tT-0\ncocaine\tO\n-\tO\ninduced\tT-1\nseizures\tB-Disease\n:\tO\ndifferential\tO\nsensitivity\tO\nof\tO\nsix\tO\ninbred\tO\nmouse\tO\nstrains\tO\n.\tO\n\nMature\tO\nmale\tO\nand\tO\nfemale\tO\nmice\tO\nfrom\tO\nsix\tO\ninbred\tO\nstains\tO\nwere\tO\ntested\tO\nfor\tO\nsusceptibility\tT-0\nto\tO\nbehavioral\tO\nseizures\tB-Disease\ninduced\tT-1\nby\tO\na\tO\nsingle\tO\ninjection\tO\nof\tO\ncocaine\tO\n.\tO\n\nMature\tO\nmale\tO\nand\tO\nfemale\tO\nmice\tO\nfrom\tO\nsix\tO\ninbred\tO\nstains\tO\nwere\tO\ntested\tO\nfor\tO\nsusceptibility\tO\nto\tO\nbehavioral\tO\nseizures\tO\ninduced\tT-0\nby\tO\na\tO\nsingle\tO\ninjection\tT-1\nof\tT-1\ncocaine\tB-Chemical\n.\tO\n\nCocaine\tB-Chemical\nwas\tT-0\ninjected\tT-0\nip\tO\nover\tO\na\tO\nrange\tO\nof\tO\ndoses\tO\n(\tO\n50\tO\n-\tO\n100\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nand\tO\nbehavior\tO\nwas\tO\nmonitored\tO\nfor\tO\n20\tO\nminutes\tO\n.\tO\n\nSeizure\tO\nend\tO\npoints\tO\nincluded\tO\nlatency\tT-0\nto\tO\nforelimb\tO\nor\tO\nhindlimb\tO\nclonus\tO\n,\tO\nlatency\tT-2\nto\tO\nclonic\tO\nrunning\tO\nseizure\tB-Disease\nand\tO\nlatency\tT-1\nto\tO\njumping\tO\nbouncing\tO\nseizure\tO\n.\tO\n\nSeizure\tO\nend\tO\npoints\tO\nincluded\tO\nlatency\tO\nto\tO\nforelimb\tO\nor\tO\nhindlimb\tO\nclonus\tO\n,\tO\nlatency\tO\nto\tO\nclonic\tO\nrunning\tO\nseizure\tO\nand\tO\nlatency\tT-0\nto\tO\njumping\tO\nbouncing\tO\nseizure\tB-Disease\n.\tO\n\nAdditionally\tO\n,\tO\nlevels\tO\nof\tO\ncocaine\tB-Chemical\ndetermined\tT-0\nin\tT-0\nhippocampus\tO\nand\tO\ncortex\tO\nwere\tO\nnot\tO\ndifferent\tO\nbetween\tO\nsensitive\tO\nand\tO\nresistant\tO\nstrains\tO\n.\tO\n\nAdditional\tO\nstudies\tO\nof\tO\nthese\tO\nmurine\tO\nstrains\tO\nmay\tO\nbe\tO\nuseful\tO\nfor\tO\ninvestigating\tO\ngenetic\tO\ninfluences\tT-1\non\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tT-2\nseizures\tO\n.\tO\n\nAdditional\tO\nstudies\tT-0\nof\tO\nthese\tO\nmurine\tO\nstrains\tT-1\nmay\tO\nbe\tO\nuseful\tO\nfor\tO\ninvestigating\tO\ngenetic\tT-2\ninfluences\tT-2\non\tO\ncocaine\tT-4\n-\tT-4\ninduced\tT-4\nseizures\tB-Disease\n.\tO\n\nHypotension\tB-Disease\nfollowing\tT-1\nthe\tT-1\ninitiation\tT-1\nof\tT-1\ntizanidine\tO\nin\tO\na\tO\npatient\tO\ntreated\tO\nwith\tO\nan\tO\nangiotensin\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\nfor\tO\nchronic\tO\nhypertension\tO\n.\tO\n\nHypotension\tO\nfollowing\tO\nthe\tO\ninitiation\tT-0\nof\tT-0\ntizanidine\tB-Chemical\nin\tT-1\na\tT-1\npatient\tT-1\ntreated\tO\nwith\tO\nan\tO\nangiotensin\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\nfor\tO\nchronic\tO\nhypertension\tO\n.\tO\n\nHypotension\tO\nfollowing\tO\nthe\tO\ninitiation\tO\nof\tO\ntizanidine\tO\nin\tO\na\tO\npatient\tO\ntreated\tT-0\nwith\tT-1\nan\tT-1\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitor\tO\nfor\tO\nchronic\tO\nhypertension\tO\n.\tO\n\nHypotension\tO\nfollowing\tO\nthe\tO\ninitiation\tO\nof\tO\ntizanidine\tO\nin\tO\na\tO\npatient\tO\ntreated\tT-1\nwith\tT-1\nan\tO\nangiotensin\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\nfor\tO\nchronic\tT-0\nhypertension\tB-Disease\n.\tO\n\nCentrally\tO\nacting\tO\nalpha\tO\n-\tO\n2\tO\nadrenergic\tO\nagonists\tO\nare\tO\none\tO\nof\tO\nseveral\tO\npharmacologic\tO\nagents\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tT-2\nof\tT-2\nspasticity\tB-Disease\nrelated\tT-1\nto\tT-1\ndisorders\tO\nof\tO\nthe\tO\ncentral\tO\nnervous\tO\nsystem\tO\n.\tO\n\nCentrally\tO\nacting\tO\nalpha\tO\n-\tO\n2\tO\nadrenergic\tO\nagonists\tO\nare\tO\none\tO\nof\tO\nseveral\tO\npharmacologic\tO\nagents\tO\nused\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nspasticity\tO\nrelated\tT-1\nto\tT-1\ndisorders\tB-Disease\nof\tI-Disease\nthe\tI-Disease\ncentral\tI-Disease\nnervous\tI-Disease\nsystem\tI-Disease\n.\tO\n\nIn\tO\naddition\tO\nto\tO\ntheir\tO\neffects\tT-0\non\tT-0\nspasticity\tB-Disease\n,\tT-1\ncertain\tT-1\nadverse\tT-1\ncardiorespiratory\tO\neffects\tO\nhave\tO\nbeen\tO\nreported\tO\n.\tO\n\nAdults\tO\nchronically\tO\ntreated\tT-0\nwith\tT-0\nangiotensin\tB-Chemical\nconverting\tO\nenzyme\tO\ninhibitors\tO\nmay\tO\nhave\tO\na\tO\nlimited\tO\nability\tO\nto\tO\nrespond\tO\nto\tO\nhypotension\tO\nwhen\tO\nthe\tO\nsympathetic\tO\nresponse\tO\nis\tO\nsimultaneously\tO\nblocked\tO\n.\tO\n\nAdults\tO\nchronically\tO\ntreated\tO\nwith\tO\nangiotensin\tO\nconverting\tO\nenzyme\tO\ninhibitors\tO\nmay\tO\nhave\tO\na\tO\nlimited\tO\nability\tO\nto\tO\nrespond\tT-1\nto\tT-1\nhypotension\tB-Disease\nwhen\tT-0\nthe\tT-0\nsympathetic\tT-0\nresponse\tT-0\nis\tO\nsimultaneously\tO\nblocked\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\n10\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nchronically\tO\ntreated\tT-0\nwith\tT-0\nlisinopril\tB-Chemical\n,\tO\nan\tO\nangiotensin\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\n,\tO\nto\tO\ncontrol\tO\nhypertension\tO\nwho\tO\ndeveloped\tO\nhypotension\tO\nfollowing\tO\nthe\tO\naddition\tO\nof\tO\ntizanidine\tO\n,\tO\nan\tO\nalpha\tO\n-\tO\n2\tO\nagonist\tO\n,\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nspasticity\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\n10\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nchronically\tO\ntreated\tT-1\nwith\tT-1\nlisinopril\tO\n,\tO\nan\tO\nangiotensin\tB-Chemical\nconverting\tT-2\nenzyme\tO\ninhibitor\tO\n,\tO\nto\tO\ncontrol\tO\nhypertension\tO\nwho\tO\ndeveloped\tT-3\nhypotension\tO\nfollowing\tO\nthe\tO\naddition\tO\nof\tO\ntizanidine\tO\n,\tO\nan\tO\nalpha\tO\n-\tO\n2\tO\nagonist\tO\n,\tO\nfor\tT-0\nthe\tT-0\ntreatment\tT-0\nof\tT-0\nspasticity\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\n10\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nchronically\tO\ntreated\tO\nwith\tO\nlisinopril\tO\n,\tO\nan\tO\nangiotensin\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\n,\tO\nto\tT-0\ncontrol\tT-0\nhypertension\tB-Disease\nwho\tT-1\ndeveloped\tT-1\nhypotension\tO\nfollowing\tO\nthe\tO\naddition\tO\nof\tO\ntizanidine\tO\n,\tO\nan\tO\nalpha\tO\n-\tO\n2\tO\nagonist\tO\n,\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nspasticity\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\n10\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nchronically\tO\ntreated\tO\nwith\tO\nlisinopril\tO\n,\tO\nan\tO\nangiotensin\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\n,\tO\nto\tO\ncontrol\tO\nhypertension\tO\nwho\tO\ndeveloped\tT-0\nhypotension\tB-Disease\nfollowing\tO\nthe\tO\naddition\tO\nof\tO\ntizanidine\tO\n,\tO\nan\tO\nalpha\tO\n-\tO\n2\tO\nagonist\tO\n,\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nspasticity\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\n10\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nchronically\tO\ntreated\tT-0\nwith\tT-0\nlisinopril\tO\n,\tO\nan\tO\nangiotensin\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\n,\tO\nto\tO\ncontrol\tO\nhypertension\tO\nwho\tO\ndeveloped\tO\nhypotension\tO\nfollowing\tT-2\nthe\tT-2\naddition\tT-2\nof\tT-2\ntizanidine\tB-Chemical\n,\tO\nan\tO\nalpha\tO\n-\tO\n2\tO\nagonist\tO\n,\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nspasticity\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\na\tO\n10\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nchronically\tO\ntreated\tO\nwith\tO\nlisinopril\tO\n,\tO\nan\tO\nangiotensin\tO\nconverting\tO\nenzyme\tO\ninhibitor\tO\n,\tO\nto\tO\ncontrol\tO\nhypertension\tO\nwho\tO\ndeveloped\tO\nhypotension\tO\nfollowing\tO\nthe\tO\naddition\tO\nof\tO\ntizanidine\tO\n,\tO\nan\tO\nalpha\tO\n-\tO\n2\tO\nagonist\tO\n,\tO\nfor\tO\nthe\tT-1\ntreatment\tT-1\nof\tT-1\nspasticity\tB-Disease\n.\tO\n\nThe\tO\npossible\tO\ninteraction\tT-1\nof\tO\ntizanidine\tB-Chemical\nand\tT-0\nother\tT-0\nantihypertensive\tO\nagents\tO\nshould\tO\nbe\tO\nkept\tO\nin\tO\nmind\tO\nwhen\tO\nprescribing\tO\ntherapy\tO\nto\tO\ntreat\tO\neither\tO\nhypertension\tO\nor\tO\nspasticity\tO\nin\tO\nsuch\tO\npatients\tO\n.\tO\n\nThe\tO\npossible\tO\ninteraction\tO\nof\tO\ntizanidine\tO\nand\tO\nother\tO\nantihypertensive\tO\nagents\tO\nshould\tO\nbe\tO\nkept\tO\nin\tO\nmind\tO\nwhen\tO\nprescribing\tO\ntherapy\tO\nto\tT-0\ntreat\tT-1\neither\tO\nhypertension\tB-Disease\nor\tO\nspasticity\tO\nin\tO\nsuch\tO\npatients\tO\n.\tO\n\nThe\tO\npossible\tO\ninteraction\tO\nof\tO\ntizanidine\tO\nand\tO\nother\tO\nantihypertensive\tO\nagents\tO\nshould\tO\nbe\tO\nkept\tO\nin\tO\nmind\tO\nwhen\tO\nprescribing\tO\ntherapy\tO\nto\tO\ntreat\tT-0\neither\tO\nhypertension\tO\nor\tO\nspasticity\tB-Disease\nin\tO\nsuch\tO\npatients\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nselected\tO\nfor\tO\ndifferential\tO\nsensitivities\tT-1\nto\tT-1\nbeta\tB-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\n-\tO\ninduced\tT-2\nseizures\tT-2\nare\tO\nalso\tO\ndifferentially\tO\nsensitive\tO\nto\tO\nvarious\tO\npharmacological\tO\neffects\tO\nof\tO\nother\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\nligands\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nselected\tO\nfor\tO\ndifferential\tO\nsensitivities\tO\nto\tO\nbeta\tO\n-\tO\ncarboline\tO\n-\tO\ninduced\tT-1\nseizures\tB-Disease\nare\tO\nalso\tO\ndifferentially\tO\nsensitive\tO\nto\tO\nvarious\tO\npharmacological\tO\neffects\tO\nof\tO\nother\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\nligands\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nselected\tO\nfor\tO\ndifferential\tO\nsensitivities\tO\nto\tO\nbeta\tO\n-\tO\ncarboline\tO\n-\tO\ninduced\tO\nseizures\tO\nare\tO\nalso\tO\ndifferentially\tO\nsensitive\tO\nto\tO\nvarious\tO\npharmacological\tO\neffects\tT-0\nof\tO\nother\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tO\nligands\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nwere\tO\nselectively\tO\nbred\tO\naccording\tO\nto\tO\ntheir\tO\nsensitivity\tO\n(\tO\nBS\tO\nline\tO\n)\tO\nor\tO\nresistance\tO\n(\tO\nBR\tO\nline\tO\n)\tO\nto\tO\nseizures\tB-Disease\ninduced\tT-0\nby\tO\na\tO\nsingle\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tO\nof\tO\nmethyl\tO\nbeta\tO\n-\tO\ncarboline\tO\n-\tO\n3\tO\n-\tO\ncarboxylate\tO\n(\tO\nbeta\tO\n-\tO\nCCM\tO\n)\tO\n,\tO\nan\tO\ninverse\tO\nagonist\tO\nof\tO\nthe\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\nbenzodiazepine\tO\nsite\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nwere\tO\nselectively\tO\nbred\tO\naccording\tO\nto\tO\ntheir\tO\nsensitivity\tO\n(\tO\nBS\tO\nline\tO\n)\tO\nor\tO\nresistance\tO\n(\tO\nBR\tO\nline\tO\n)\tO\nto\tO\nseizures\tO\ninduced\tO\nby\tO\na\tO\nsingle\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tT-0\nof\tT-0\nmethyl\tB-Chemical\nbeta\tI-Chemical\n-\tI-Chemical\ncarboline\tI-Chemical\n-\tI-Chemical\n3\tI-Chemical\n-\tI-Chemical\ncarboxylate\tI-Chemical\n(\tT-1\nbeta\tT-1\n-\tT-1\nCCM\tT-1\n)\tT-1\n,\tO\nan\tO\ninverse\tO\nagonist\tO\nof\tO\nthe\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\nbenzodiazepine\tO\nsite\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nwere\tO\nselectively\tO\nbred\tO\naccording\tO\nto\tO\ntheir\tO\nsensitivity\tO\n(\tO\nBS\tO\nline\tO\n)\tO\nor\tO\nresistance\tO\n(\tO\nBR\tO\nline\tO\n)\tO\nto\tO\nseizures\tO\ninduced\tO\nby\tO\na\tO\nsingle\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tT-0\nof\tT-0\nmethyl\tO\nbeta\tO\n-\tO\ncarboline\tO\n-\tO\n3\tO\n-\tO\ncarboxylate\tO\n(\tO\nbeta\tB-Chemical\n-\tI-Chemical\nCCM\tI-Chemical\n)\tO\n,\tO\nan\tT-1\ninverse\tT-1\nagonist\tO\nof\tO\nthe\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\nbenzodiazepine\tO\nsite\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nwere\tO\nselectively\tO\nbred\tO\naccording\tO\nto\tO\ntheir\tO\nsensitivity\tO\n(\tO\nBS\tO\nline\tO\n)\tO\nor\tO\nresistance\tO\n(\tO\nBR\tO\nline\tO\n)\tO\nto\tO\nseizures\tO\ninduced\tT-1\nby\tT-1\na\tO\nsingle\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tO\nof\tO\nmethyl\tO\nbeta\tO\n-\tO\ncarboline\tO\n-\tO\n3\tO\n-\tO\ncarboxylate\tO\n(\tO\nbeta\tO\n-\tO\nCCM\tO\n)\tO\n,\tO\nan\tO\ninverse\tT-3\nagonist\tT-3\nof\tT-3\nthe\tO\nGABA\tB-Chemical\n(\tT-0\nA\tT-0\n)\tT-0\nreceptor\tT-0\nbenzodiazepine\tO\nsite\tO\n.\tO\n\nTwo\tO\nmouse\tO\nlines\tO\nwere\tO\nselectively\tO\nbred\tO\naccording\tO\nto\tO\ntheir\tO\nsensitivity\tO\n(\tO\nBS\tO\nline\tO\n)\tO\nor\tO\nresistance\tO\n(\tO\nBR\tO\nline\tO\n)\tO\nto\tO\nseizures\tO\ninduced\tO\nby\tO\na\tO\nsingle\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjection\tO\nof\tO\nmethyl\tO\nbeta\tO\n-\tO\ncarboline\tO\n-\tO\n3\tO\n-\tO\ncarboxylate\tO\n(\tO\nbeta\tO\n-\tO\nCCM\tO\n)\tO\n,\tO\nan\tO\ninverse\tO\nagonist\tO\nof\tO\nthe\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\nbenzodiazepine\tB-Chemical\nsite\tT-0\n.\tO\n\nOur\tO\naim\tO\nwas\tO\nto\tO\ncharacterize\tO\nboth\tO\nlines\tO\n'\tO\nsensitivities\tT-2\nto\tT-2\nvarious\tO\nphysiological\tO\neffects\tO\nof\tO\nother\tO\nligands\tO\nof\tT-0\nthe\tT-0\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nreceptor\tT-1\n.\tO\n\nWe\tT-0\nmeasured\tT-0\ndiazepam\tB-Chemical\n-\tO\ninduced\tO\nanxiolysis\tO\nwith\tO\nthe\tO\nelevated\tO\nplus\tO\n-\tO\nmaze\tO\ntest\tO\n,\tO\ndiazepam\tO\n-\tO\ninduced\tO\nsedation\tO\nby\tO\nrecording\tO\nthe\tO\nvigilance\tO\nstates\tO\n,\tO\nand\tO\npicrotoxin\tO\n-\tO\nand\tO\npentylenetetrazol\tO\n-\tO\ninduced\tO\nseizures\tO\nafter\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\n.\tO\n\nWe\tO\nmeasured\tO\ndiazepam\tO\n-\tO\ninduced\tO\nanxiolysis\tO\nwith\tO\nthe\tO\nelevated\tO\nplus\tO\n-\tO\nmaze\tO\ntest\tO\n,\tO\ndiazepam\tB-Chemical\n-\tO\ninduced\tT-0\nsedation\tO\nby\tO\nrecording\tO\nthe\tO\nvigilance\tO\nstates\tO\n,\tO\nand\tO\npicrotoxin\tO\n-\tO\nand\tO\npentylenetetrazol\tO\n-\tO\ninduced\tO\nseizures\tO\nafter\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\n.\tO\n\nWe\tO\nmeasured\tO\ndiazepam\tO\n-\tO\ninduced\tO\nanxiolysis\tO\nwith\tO\nthe\tO\nelevated\tO\nplus\tO\n-\tO\nmaze\tO\ntest\tO\n,\tO\ndiazepam\tO\n-\tO\ninduced\tO\nsedation\tO\nby\tO\nrecording\tO\nthe\tO\nvigilance\tO\nstates\tO\n,\tO\nand\tO\npicrotoxin\tB-Chemical\n-\tO\nand\tO\npentylenetetrazol\tO\n-\tO\ninduced\tT-0\nseizures\tO\nafter\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\n.\tO\n\nWe\tO\nmeasured\tO\ndiazepam\tO\n-\tO\ninduced\tO\nanxiolysis\tO\nwith\tO\nthe\tO\nelevated\tO\nplus\tO\n-\tO\nmaze\tO\ntest\tO\n,\tO\ndiazepam\tO\n-\tO\ninduced\tO\nsedation\tO\nby\tO\nrecording\tO\nthe\tO\nvigilance\tO\nstates\tO\n,\tO\nand\tO\npicrotoxin\tO\n-\tO\nand\tO\npentylenetetrazol\tB-Chemical\n-\tT-1\ninduced\tT-1\nseizures\tO\nafter\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\n.\tO\n\nWe\tO\nmeasured\tO\ndiazepam\tO\n-\tO\ninduced\tT-0\nanxiolysis\tO\nwith\tO\nthe\tO\nelevated\tO\nplus\tO\n-\tO\nmaze\tO\ntest\tO\n,\tO\ndiazepam\tO\n-\tO\ninduced\tO\nsedation\tO\nby\tO\nrecording\tO\nthe\tO\nvigilance\tO\nstates\tO\n,\tO\nand\tO\npicrotoxin\tO\n-\tO\nand\tO\npentylenetetrazol\tO\n-\tO\ninduced\tT-1\nseizures\tB-Disease\nafter\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\n.\tO\n\nResults\tO\npresented\tO\nhere\tO\nshow\tO\nthat\tO\nthe\tO\ndifferential\tT-1\nsensitivities\tT-1\nof\tO\nBS\tO\nand\tO\nBR\tO\nlines\tT-0\nto\tT-0\nbeta\tB-Chemical\n-\tI-Chemical\nCCM\tI-Chemical\ncan\tO\nbe\tO\nextended\tO\nto\tO\ndiazepam\tO\n,\tO\npicrotoxin\tO\n,\tO\nand\tO\npentylenetetrazol\tO\n,\tO\nsuggesting\tO\na\tO\ngenetic\tO\nselection\tO\nof\tO\na\tO\ngeneral\tO\nsensitivity\tO\nand\tO\nresistance\tO\nto\tO\nseveral\tO\nligands\tO\nof\tO\nthe\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\n.\tO\n\nResults\tO\npresented\tO\nhere\tO\nshow\tO\nthat\tO\nthe\tO\ndifferential\tT-2\nsensitivities\tT-2\nof\tO\nBS\tO\nand\tO\nBR\tO\nlines\tO\nto\tO\nbeta\tO\n-\tO\nCCM\tO\ncan\tT-0\nbe\tT-0\nextended\tT-3\nto\tO\ndiazepam\tB-Chemical\n,\tO\npicrotoxin\tO\n,\tO\nand\tO\npentylenetetrazol\tO\n,\tO\nsuggesting\tT-1\na\tO\ngenetic\tO\nselection\tO\nof\tO\na\tO\ngeneral\tO\nsensitivity\tO\nand\tO\nresistance\tO\nto\tO\nseveral\tO\nligands\tO\nof\tO\nthe\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\n.\tO\n\nResults\tO\npresented\tO\nhere\tO\nshow\tO\nthat\tO\nthe\tO\ndifferential\tO\nsensitivities\tO\nof\tO\nBS\tO\nand\tO\nBR\tO\nlines\tO\nto\tO\nbeta\tO\n-\tO\nCCM\tO\ncan\tO\nbe\tO\nextended\tT-0\nto\tT-0\ndiazepam\tO\n,\tO\npicrotoxin\tB-Chemical\n,\tO\nand\tT-1\npentylenetetrazol\tO\n,\tO\nsuggesting\tO\na\tO\ngenetic\tO\nselection\tO\nof\tO\na\tO\ngeneral\tO\nsensitivity\tO\nand\tO\nresistance\tO\nto\tO\nseveral\tO\nligands\tO\nof\tO\nthe\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\n.\tO\n\nResults\tO\npresented\tO\nhere\tO\nshow\tO\nthat\tO\nthe\tO\ndifferential\tO\nsensitivities\tO\nof\tO\nBS\tO\nand\tO\nBR\tO\nlines\tO\nto\tO\nbeta\tO\n-\tO\nCCM\tO\ncan\tT-0\nbe\tT-0\nextended\tT-0\nto\tT-0\ndiazepam\tO\n,\tO\npicrotoxin\tO\n,\tO\nand\tO\npentylenetetrazol\tB-Chemical\n,\tO\nsuggesting\tT-1\na\tO\ngenetic\tO\nselection\tO\nof\tO\na\tO\ngeneral\tO\nsensitivity\tO\nand\tO\nresistance\tO\nto\tO\nseveral\tO\nligands\tO\nof\tO\nthe\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nreceptor\tO\n.\tO\n\nResults\tO\npresented\tO\nhere\tO\nshow\tO\nthat\tO\nthe\tO\ndifferential\tO\nsensitivities\tO\nof\tO\nBS\tO\nand\tO\nBR\tO\nlines\tO\nto\tO\nbeta\tO\n-\tO\nCCM\tO\ncan\tO\nbe\tO\nextended\tO\nto\tO\ndiazepam\tO\n,\tO\npicrotoxin\tO\n,\tO\nand\tO\npentylenetetrazol\tO\n,\tO\nsuggesting\tT-1\na\tO\ngenetic\tO\nselection\tO\nof\tO\na\tO\ngeneral\tO\nsensitivity\tO\nand\tO\nresistance\tO\nto\tO\nseveral\tO\nligands\tO\nof\tT-0\nthe\tT-0\nGABA\tB-Chemical\n(\tT-2\nA\tT-2\n)\tT-2\nreceptor\tT-2\n.\tO\n\nPropylthiouracil\tB-Chemical\n-\tT-0\ninduced\tT-0\nperinuclear\tO\n-\tO\nstaining\tO\nantineutrophil\tO\ncytoplasmic\tO\nautoantibody\tO\n-\tO\npositive\tO\nvasculitis\tO\nin\tO\nconjunction\tO\nwith\tO\npericarditis\tO\n.\tO\n\nPropylthiouracil\tO\n-\tO\ninduced\tT-1\nperinuclear\tO\n-\tO\nstaining\tO\nantineutrophil\tO\ncytoplasmic\tO\nautoantibody\tT-0\n-\tT-0\npositive\tT-0\nvasculitis\tB-Disease\nin\tO\nconjunction\tO\nwith\tO\npericarditis\tO\n.\tO\n\nPropylthiouracil\tO\n-\tO\ninduced\tT-0\nperinuclear\tO\n-\tO\nstaining\tO\nantineutrophil\tO\ncytoplasmic\tO\nautoantibody\tO\n-\tO\npositive\tO\nvasculitis\tO\nin\tT-1\nconjunction\tT-1\nwith\tT-1\npericarditis\tB-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\na\tT-0\ncase\tT-0\nof\tT-0\npropylthiouracil\tB-Chemical\n-\tO\ninduced\tT-1\nvasculitis\tO\nmanifesting\tO\nwith\tO\npericarditis\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\npropylthiouracil\tO\n-\tO\ninduced\tT-1\nvasculitis\tB-Disease\nmanifesting\tT-2\nwith\tT-2\npericarditis\tT-2\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\ndescribe\tO\na\tO\ncase\tO\nof\tO\npropylthiouracil\tO\n-\tO\ninduced\tO\nvasculitis\tO\nmanifesting\tT-0\nwith\tT-0\npericarditis\tB-Disease\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\npresent\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\na\tO\nwoman\tO\nwith\tO\nhyperthyroidism\tB-Disease\ntreated\tT-1\nwith\tO\npropylthiouracil\tO\nin\tO\nwhom\tO\na\tO\nsyndrome\tO\nof\tO\npericarditis\tO\n,\tO\nfever\tO\n,\tO\nand\tO\nglomerulonephritis\tO\ndeveloped\tT-0\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\npresent\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\na\tO\nwoman\tO\nwith\tO\nhyperthyroidism\tO\ntreated\tT-0\nwith\tT-0\npropylthiouracil\tB-Chemical\nin\tO\nwhom\tO\na\tO\nsyndrome\tO\nof\tO\npericarditis\tO\n,\tO\nfever\tO\n,\tO\nand\tO\nglomerulonephritis\tO\ndeveloped\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\npresent\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\na\tO\nwoman\tO\nwith\tO\nhyperthyroidism\tO\ntreated\tO\nwith\tO\npropylthiouracil\tO\nin\tO\nwhom\tO\na\tO\nsyndrome\tT-0\nof\tT-0\npericarditis\tB-Disease\n,\tT-1\nfever\tT-1\n,\tO\nand\tO\nglomerulonephritis\tO\ndeveloped\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\npresent\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\na\tO\nwoman\tO\nwith\tO\nhyperthyroidism\tO\ntreated\tO\nwith\tO\npropylthiouracil\tO\nin\tO\nwhom\tO\na\tO\nsyndrome\tT-3\nof\tT-3\npericarditis\tT-0\n,\tT-0\nfever\tB-Disease\n,\tT-1\nand\tT-1\nglomerulonephritis\tT-1\ndeveloped\tT-2\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\npresent\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\na\tO\nwoman\tO\nwith\tO\nhyperthyroidism\tO\ntreated\tT-1\nwith\tT-1\npropylthiouracil\tO\nin\tO\nwhom\tO\na\tO\nsyndrome\tT-0\nof\tT-0\npericarditis\tO\n,\tO\nfever\tO\n,\tO\nand\tO\nglomerulonephritis\tB-Disease\ndeveloped\tT-2\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nGraves\tB-Disease\n'\tI-Disease\ndisease\tI-Disease\nhad\tT-0\na\tT-0\nfebrile\tT-0\nillness\tT-0\nand\tO\nevidence\tT-1\nof\tT-1\npericarditis\tO\n,\tO\nwhich\tO\nwas\tO\nconfirmed\tT-2\nby\tO\nbiopsy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nGraves\tO\n'\tO\ndisease\tT-0\nhad\tT-0\na\tT-0\nfebrile\tB-Disease\nillness\tI-Disease\nand\tO\nevidence\tT-1\nof\tT-1\npericarditis\tO\n,\tO\nwhich\tO\nwas\tO\nconfirmed\tO\nby\tO\nbiopsy\tO\n.\tO\n\nRESULTS\tO\n:\tO\nA\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\nGraves\tO\n'\tO\ndisease\tO\nhad\tO\na\tO\nfebrile\tO\nillness\tO\nand\tO\nevidence\tT-0\nof\tT-0\npericarditis\tB-Disease\n,\tO\nwhich\tO\nwas\tO\nconfirmed\tT-1\nby\tO\nbiopsy\tO\n.\tO\n\nPropylthiouracil\tB-Chemical\ntherapy\tT-0\nwas\tO\nwithdrawn\tO\n,\tO\nand\tO\nshe\tO\nwas\tO\ntreated\tO\nwith\tO\na\tO\n1\tO\n-\tO\nmonth\tO\ncourse\tO\nof\tO\nprednisone\tO\n,\tO\nwhich\tO\nalleviated\tO\nher\tO\nsymptoms\tO\n.\tO\n\nPropylthiouracil\tO\ntherapy\tO\nwas\tO\nwithdrawn\tT-0\n,\tO\nand\tO\nshe\tO\nwas\tO\ntreated\tT-1\nwith\tT-1\na\tO\n1\tO\n-\tO\nmonth\tO\ncourse\tT-2\nof\tT-2\nprednisone\tB-Chemical\n,\tO\nwhich\tT-3\nalleviated\tO\nher\tO\nsymptoms\tO\n.\tO\n\nA\tO\nliterature\tO\nreview\tO\nrevealed\tO\nno\tO\nprior\tO\nreports\tO\nof\tO\npericarditis\tB-Disease\nin\tO\nanti\tO\n-\tO\nMPO\tO\npANCA\tO\n-\tO\npositive\tO\nvasculitis\tO\nassociated\tT-0\nwith\tT-0\npropylthio\tO\n-\tO\nuracil\tO\ntherapy\tO\n.\tO\n\nA\tO\nliterature\tO\nreview\tO\nrevealed\tO\nno\tO\nprior\tO\nreports\tO\nof\tO\npericarditis\tO\nin\tO\nanti\tO\n-\tO\nMPO\tO\npANCA\tO\n-\tO\npositive\tO\nvasculitis\tB-Disease\nassociated\tT-0\nwith\tT-0\npropylthio\tO\n-\tO\nuracil\tO\ntherapy\tO\n.\tO\n\nA\tO\nliterature\tO\nreview\tO\nrevealed\tO\nno\tO\nprior\tO\nreports\tO\nof\tO\npericarditis\tO\nin\tO\nanti\tO\n-\tO\nMPO\tO\npANCA\tO\n-\tO\npositive\tO\nvasculitis\tO\nassociated\tT-0\nwith\tT-0\npropylthio\tB-Chemical\n-\tI-Chemical\nuracil\tI-Chemical\ntherapy\tT-1\n.\tO\n\nCONCLUSION\tO\n:\tO\nPericarditis\tB-Disease\nmay\tT-0\nbe\tT-0\nthe\tO\ninitial\tO\nmanifestation\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\nvasculitis\tO\nattributable\tO\nto\tO\npropylthio\tO\n-\tO\nuracil\tO\ntherapy\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nPericarditis\tO\nmay\tO\nbe\tO\nthe\tO\ninitial\tO\nmanifestation\tT-1\nof\tO\ndrug\tO\n-\tO\ninduced\tT-2\nvasculitis\tB-Disease\nattributable\tO\nto\tO\npropylthio\tO\n-\tO\nuracil\tO\ntherapy\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nPericarditis\tO\nmay\tO\nbe\tO\nthe\tO\ninitial\tO\nmanifestation\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tT-0\nvasculitis\tO\nattributable\tO\nto\tO\npropylthio\tB-Chemical\n-\tI-Chemical\nuracil\tI-Chemical\ntherapy\tO\n.\tO\n\nRepeated\tO\ntransient\tO\nanuria\tB-Disease\nfollowing\tO\nlosartan\tO\nadministration\tT-0\nin\tO\na\tO\npatient\tT-1\nwith\tO\na\tO\nsolitary\tT-2\nkidney\tT-2\n.\tO\n\nRepeated\tO\ntransient\tO\nanuria\tO\nfollowing\tT-2\nlosartan\tB-Chemical\nadministration\tT-3\nin\tO\na\tO\npatient\tO\nwith\tO\na\tO\nsolitary\tO\nkidney\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n70\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nhypertensive\tO\nman\tT-0\nwith\tT-0\na\tO\nsolitary\tO\nkidney\tO\nand\tO\nchronic\tB-Disease\nrenal\tI-Disease\ninsufficiency\tI-Disease\nwho\tO\ndeveloped\tO\ntwo\tO\nepisodes\tO\nof\tO\ntransient\tO\nanuria\tO\nafter\tO\nlosartan\tO\nadministration\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n70\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nhypertensive\tO\nman\tO\nwith\tO\na\tO\nsolitary\tO\nkidney\tO\nand\tO\nchronic\tO\nrenal\tO\ninsufficiency\tO\nwho\tO\ndeveloped\tT-1\ntwo\tO\nepisodes\tO\nof\tO\ntransient\tT-0\nanuria\tB-Disease\nafter\tT-2\nlosartan\tO\nadministration\tO\n.\tO\n\nWe\tO\nreport\tO\nthe\tO\ncase\tO\nof\tO\na\tO\n70\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nhypertensive\tO\nman\tO\nwith\tO\na\tO\nsolitary\tO\nkidney\tO\nand\tO\nchronic\tO\nrenal\tO\ninsufficiency\tO\nwho\tO\ndeveloped\tT-1\ntwo\tO\nepisodes\tO\nof\tO\ntransient\tO\nanuria\tO\nafter\tO\nlosartan\tB-Chemical\nadministration\tT-0\n.\tO\n\nHe\tO\nwas\tO\nhospitalized\tO\nfor\tT-0\na\tT-0\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwith\tT-1\npulmonary\tO\nedema\tO\n,\tO\ntreated\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\ndiuretics\tO\n.\tO\n\nHe\tO\nwas\tO\nhospitalized\tT-0\nfor\tT-0\na\tO\nmyocardial\tO\ninfarction\tO\nwith\tO\npulmonary\tB-Disease\nedema\tI-Disease\n,\tO\ntreated\tO\nwith\tO\nhigh\tO\n-\tO\ndose\tO\ndiuretics\tO\n.\tO\n\nDue\tT-0\nto\tT-0\nsevere\tT-0\nsystolic\tB-Disease\ndysfunction\tI-Disease\nlosartan\tO\nwas\tT-1\nprescribed\tT-1\n.\tO\n\nDue\tO\nto\tO\nsevere\tT-0\nsystolic\tT-0\ndysfunction\tT-0\nlosartan\tB-Chemical\nwas\tT-1\nprescribed\tT-1\n.\tO\n\nSurprisingly\tO\n,\tO\nthe\tO\nfirst\tO\ndose\tT-0\nof\tT-0\n50\tO\nmg\tO\nof\tO\nlosartan\tB-Chemical\nresulted\tT-1\nin\tT-1\na\tO\nsudden\tO\nanuria\tO\n,\tO\nwhich\tO\nlasted\tO\neight\tO\nhours\tO\ndespite\tO\nhigh\tO\n-\tO\ndose\tO\nfurosemide\tO\nand\tO\namine\tO\ninfusion\tO\n.\tO\n\nSurprisingly\tO\n,\tO\nthe\tO\nfirst\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\nof\tO\nlosartan\tO\nresulted\tT-0\nin\tT-0\na\tO\nsudden\tT-2\nanuria\tB-Disease\n,\tO\nwhich\tT-1\nlasted\tO\neight\tO\nhours\tO\ndespite\tO\nhigh\tO\n-\tO\ndose\tO\nfurosemide\tO\nand\tO\namine\tO\ninfusion\tO\n.\tO\n\nSurprisingly\tO\n,\tO\nthe\tO\nfirst\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\nof\tO\nlosartan\tO\nresulted\tT-1\nin\tT-1\na\tO\nsudden\tO\nanuria\tO\n,\tO\nwhich\tO\nlasted\tO\neight\tO\nhours\tO\ndespite\tO\nhigh\tT-0\n-\tT-0\ndose\tT-0\nfurosemide\tB-Chemical\nand\tO\namine\tO\ninfusion\tO\n.\tO\n\nSurprisingly\tO\n,\tO\nthe\tO\nfirst\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\nof\tO\nlosartan\tO\nresulted\tO\nin\tO\na\tO\nsudden\tT-1\nanuria\tO\n,\tO\nwhich\tO\nlasted\tO\neight\tO\nhours\tO\ndespite\tT-2\nhigh\tT-0\n-\tT-0\ndose\tT-0\nfurosemide\tO\nand\tO\namine\tB-Chemical\ninfusion\tT-3\n.\tO\n\nOne\tO\nweek\tO\nlater\tO\n,\tO\nby\tO\nmistake\tO\n,\tO\nlosartan\tB-Chemical\nwas\tT-0\nprescribed\tT-0\nagain\tO\nand\tO\nafter\tO\nthe\tO\nsecond\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\n,\tO\nthe\tO\npatient\tO\ndeveloped\tO\na\tO\nsecond\tO\nepisode\tO\nof\tO\ntransient\tO\nanuria\tO\nlasting\tO\n10\tO\nhours\tO\n.\tO\n\nOne\tO\nweek\tO\nlater\tO\n,\tO\nby\tO\nmistake\tO\n,\tO\nlosartan\tO\nwas\tO\nprescribed\tO\nagain\tO\nand\tO\nafter\tO\nthe\tO\nsecond\tO\ndose\tO\nof\tO\n50\tO\nmg\tO\n,\tO\nthe\tO\npatient\tO\ndeveloped\tO\na\tO\nsecond\tO\nepisode\tO\nof\tT-1\ntransient\tT-1\nanuria\tB-Disease\nlasting\tT-2\n10\tO\nhours\tO\n.\tO\n\nDuring\tO\nthese\tO\ntwo\tO\nepisodes\tO\n,\tO\nhis\tO\nblood\tO\npressure\tO\ndiminished\tT-0\nbut\tO\nno\tO\nsevere\tO\nhypotension\tB-Disease\nwas\tT-1\nnoted\tT-1\n.\tO\n\nUltimately\tO\n,\tO\nan\tO\narteriography\tO\nshowed\tT-0\na\tO\n70\tO\n-\tO\n80\tO\n%\tO\nrenal\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\n.\tO\n\nIn\tO\nthis\tO\npatient\tO\n,\tO\nrenal\tB-Disease\nartery\tI-Disease\nstenosis\tI-Disease\ncombined\tT-0\nwith\tT-0\nheart\tO\nfailure\tO\nand\tO\ndiuretic\tO\ntherapy\tO\ncertainly\tO\nresulted\tO\nin\tO\na\tO\nstrong\tO\nactivation\tT-1\nof\tO\nthe\tO\nrenin\tO\n-\tO\nangiotensin\tO\nsystem\tO\n(\tO\nRAS\tO\n)\tO\n.\tO\n\nIn\tO\nthis\tO\npatient\tO\n,\tO\nrenal\tO\nartery\tO\nstenosis\tO\ncombined\tT-0\nwith\tT-0\nheart\tB-Disease\nfailure\tI-Disease\nand\tO\ndiuretic\tO\ntherapy\tO\ncertainly\tO\nresulted\tT-3\nin\tT-3\na\tO\nstrong\tO\nactivation\tT-2\nof\tO\nthe\tO\nrenin\tO\n-\tO\nangiotensin\tO\nsystem\tO\n(\tO\nRAS\tO\n)\tO\n.\tO\n\nIn\tO\nthis\tO\npatient\tO\n,\tO\nrenal\tO\nartery\tO\nstenosis\tO\ncombined\tO\nwith\tO\nheart\tO\nfailure\tO\nand\tO\ndiuretic\tO\ntherapy\tO\ncertainly\tO\nresulted\tO\nin\tO\na\tO\nstrong\tT-1\nactivation\tT-1\nof\tT-1\nthe\tO\nrenin\tO\n-\tO\nangiotensin\tB-Chemical\nsystem\tO\n(\tO\nRAS\tO\n)\tO\n.\tO\n\nUnder\tT-1\nsuch\tT-1\nconditions\tT-1\n,\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tO\nblockade\tO\nby\tO\nlosartan\tO\nprobably\tO\ninduced\tT-2\na\tO\ncritical\tO\nfall\tT-0\nin\tO\nglomerular\tO\nfiltration\tO\npressure\tO\n.\tO\n\nUnder\tO\nsuch\tO\nconditions\tO\n,\tO\nangiotensin\tO\nII\tO\nreceptor\tO\nblockade\tO\nby\tO\nlosartan\tB-Chemical\nprobably\tO\ninduced\tT-0\na\tO\ncritical\tO\nfall\tO\nin\tO\nglomerular\tO\nfiltration\tO\npressure\tO\n.\tO\n\nThis\tO\ncase\tO\nreport\tO\nhighlights\tO\nthe\tO\nfact\tO\nthat\tO\nthe\tO\nangiotensin\tB-Chemical\nII\tI-Chemical\nreceptor\tT-3\nantagonist\tT-3\nlosartan\tO\ncan\tT-0\ncause\tT-0\nserious\tO\nunexpected\tO\ncomplications\tT-1\nin\tT-1\npatients\tO\nwith\tO\nrenovascular\tO\ndisease\tO\nand\tO\nshould\tO\nbe\tT-2\nused\tT-2\nwith\tT-2\nextreme\tO\ncaution\tO\nin\tO\nthis\tO\nsetting\tO\n.\tO\n\nThis\tO\ncase\tO\nreport\tO\nhighlights\tO\nthe\tO\nfact\tO\nthat\tO\nthe\tO\nangiotensin\tO\nII\tO\nreceptor\tO\nantagonist\tO\nlosartan\tB-Chemical\ncan\tT-0\ncause\tT-0\nserious\tO\nunexpected\tO\ncomplications\tO\nin\tO\npatients\tO\nwith\tO\nrenovascular\tO\ndisease\tO\nand\tO\nshould\tO\nbe\tO\nused\tO\nwith\tO\nextreme\tO\ncaution\tO\nin\tO\nthis\tO\nsetting\tO\n.\tO\n\nThis\tO\ncase\tO\nreport\tO\nhighlights\tO\nthe\tO\nfact\tO\nthat\tO\nthe\tO\nangiotensin\tO\nII\tO\nreceptor\tO\nantagonist\tO\nlosartan\tO\ncan\tO\ncause\tO\nserious\tO\nunexpected\tO\ncomplications\tT-0\nin\tT-0\npatients\tT-0\nwith\tT-0\nrenovascular\tB-Disease\ndisease\tI-Disease\nand\tO\nshould\tO\nbe\tO\nused\tO\nwith\tO\nextreme\tO\ncaution\tO\nin\tO\nthis\tO\nsetting\tO\n.\tO\n\nCalcineurin\tO\n-\tO\ninhibitor\tO\ninduced\tT-2\npain\tB-Disease\nsyndrome\tT-0\n(\tO\nCIPS\tO\n)\tO\n:\tO\na\tO\nsevere\tT-1\ndisabling\tT-1\ncomplication\tT-1\nafter\tO\norgan\tO\ntransplantation\tO\n.\tO\n\nCalcineurin\tO\n-\tO\ninhibitor\tO\ninduced\tT-3\npain\tO\nsyndrome\tT-0\n(\tO\nCIPS\tB-Disease\n)\tO\n:\tT-2\na\tT-2\nsevere\tT-2\ndisabling\tT-2\ncomplication\tT-4\nafter\tO\norgan\tO\ntransplantation\tO\n.\tO\n\nBone\tO\npain\tB-Disease\nafter\tO\ntransplantation\tT-0\nis\tO\na\tO\nfrequent\tO\ncomplication\tO\nthat\tO\ncan\tO\nbe\tO\ncaused\tT-1\nby\tT-1\nseveral\tO\ndiseases\tO\n.\tO\n\nTreatment\tO\nstrategies\tO\ndepend\tT-1\non\tT-1\nthe\tO\ncorrect\tO\ndiagnosis\tT-0\nof\tT-0\nthe\tO\npain\tB-Disease\n.\tO\n\nNine\tO\npatients\tT-0\nwith\tT-0\nsevere\tT-1\npain\tB-Disease\nin\tO\ntheir\tO\nfeet\tO\n,\tO\nwhich\tO\nwas\tO\nregistered\tO\nafter\tO\ntransplantation\tO\n,\tO\nwere\tO\ninvestigated\tO\n.\tO\n\nMagnetic\tT-2\nresonance\tT-2\nimaging\tO\ndemonstrated\tT-1\nbone\tB-Disease\nmarrow\tI-Disease\noedema\tI-Disease\nin\tT-0\nthe\tT-0\npainful\tO\nbones\tO\n.\tO\n\nPain\tB-Disease\nwas\tO\nnot\tO\nexplained\tT-0\nby\tO\nother\tO\ndiseases\tO\ncausing\tO\nfoot\tO\npain\tO\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tT-0\nexplained\tT-0\nby\tT-0\nother\tO\ndiseases\tO\ncausing\tT-1\nfoot\tT-1\npain\tB-Disease\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tO\nexplained\tT-0\nby\tT-0\nother\tO\ndiseases\tO\ncausing\tT-1\nfoot\tO\npain\tO\n,\tO\nlike\tO\nreflex\tB-Disease\nsympathetic\tI-Disease\ndystrophy\tI-Disease\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tO\nexplained\tO\nby\tO\nother\tO\ndiseases\tT-0\ncausing\tT-0\nfoot\tT-0\npain\tT-0\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tB-Disease\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tO\nexplained\tT-0\nby\tT-0\nother\tO\ndiseases\tO\ncausing\tT-1\nfoot\tO\npain\tO\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tB-Disease\n'\tI-Disease\ns\tI-Disease\nneuralgia\tI-Disease\n,\tO\ngout\tO\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tO\nexplained\tO\nby\tO\nother\tO\ndiseases\tO\ncausing\tT-0\nfoot\tO\npain\tO\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tT-1\n'\tT-1\ns\tT-1\nneuralgia\tT-1\n,\tO\ngout\tB-Disease\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tO\nexplained\tO\nby\tO\nother\tO\ndiseases\tO\ncausing\tT-0\nfoot\tO\npain\tO\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tB-Disease\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tT-2\nexplained\tT-2\nby\tT-2\nother\tO\ndiseases\tO\ncausing\tO\nfoot\tO\npain\tO\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tT-0\n,\tT-0\navascular\tB-Disease\nnecrosis\tI-Disease\n,\tT-1\nintermittent\tT-1\nclaudication\tT-1\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tO\nexplained\tT-0\nby\tT-1\nother\tT-1\ndiseases\tT-1\ncausing\tO\nfoot\tO\npain\tO\n,\tO\nlike\tT-2\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tB-Disease\nclaudication\tI-Disease\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tO\nexplained\tO\nby\tO\nother\tO\ndiseases\tO\ncausing\tO\nfoot\tO\npain\tO\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tT-0\nfoot\tB-Disease\ndeformities\tI-Disease\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tO\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tO\nexplained\tO\nby\tO\nother\tO\ndiseases\tO\ncausing\tO\nfoot\tO\npain\tO\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tB-Disease\nfractures\tI-Disease\n,\tO\nand\tT-0\nhyperparathyroidism\tO\n.\tO\n\nPain\tO\nwas\tO\nnot\tO\nexplained\tO\nby\tO\nother\tO\ndiseases\tO\ncausing\tO\nfoot\tO\npain\tO\n,\tO\nlike\tO\nreflex\tO\nsympathetic\tO\ndystrophy\tO\n,\tO\npolyneuropathy\tO\n,\tO\nMorton\tO\n'\tO\ns\tO\nneuralgia\tO\n,\tO\ngout\tO\n,\tO\nosteoporosis\tO\n,\tO\navascular\tO\nnecrosis\tO\n,\tO\nintermittent\tO\nclaudication\tO\n,\tO\northopaedic\tO\nfoot\tO\ndeformities\tO\n,\tO\nstress\tO\nfractures\tO\n,\tO\nand\tT-0\nhyperparathyroidism\tB-Disease\n.\tO\n\nThe\tO\nreduction\tT-0\nof\tT-0\ncyclosporine\tB-Chemical\n-\tO\nor\tO\ntacrolimus\tO\ntrough\tO\nlevels\tO\nand\tO\nthe\tO\nadministration\tT-1\nof\tT-1\ncalcium\tO\nchannel\tO\nblockers\tO\nled\tO\nto\tO\nrelief\tT-2\nof\tO\npain\tO\n.\tO\n\nThe\tO\nreduction\tT-0\nof\tO\ncyclosporine\tO\n-\tO\nor\tO\ntacrolimus\tB-Chemical\ntrough\tO\nlevels\tO\nand\tO\nthe\tO\nadministration\tT-1\nof\tO\ncalcium\tO\nchannel\tO\nblockers\tO\nled\tT-2\nto\tT-2\nrelief\tT-2\nof\tT-2\npain\tT-2\n.\tO\n\nThe\tO\nreduction\tO\nof\tO\ncyclosporine\tO\n-\tO\nor\tO\ntacrolimus\tO\ntrough\tO\nlevels\tT-0\nand\tO\nthe\tO\nadministration\tT-2\nof\tT-2\ncalcium\tB-Chemical\nchannel\tO\nblockers\tO\nled\tO\nto\tO\nrelief\tO\nof\tO\npain\tO\n.\tO\n\nThe\tO\nreduction\tO\nof\tO\ncyclosporine\tO\n-\tO\nor\tO\ntacrolimus\tO\ntrough\tO\nlevels\tO\nand\tO\nthe\tO\nadministration\tO\nof\tO\ncalcium\tO\nchannel\tO\nblockers\tO\nled\tT-2\nto\tT-2\nrelief\tT-1\nof\tT-1\npain\tB-Disease\n.\tO\n\nThe\tO\nCalcineurin\tO\n-\tO\ninhibitor\tO\nInduced\tT-0\nPain\tB-Disease\nSyndrome\tO\n(\tO\nCIPS\tO\n)\tO\nis\tO\na\tO\nrare\tO\nbut\tO\nsevere\tO\nside\tO\neffect\tO\nof\tO\ncyclosporine\tO\nor\tO\ntacrolimus\tO\nand\tO\nis\tO\naccurately\tO\ndiagnosed\tO\nby\tO\nits\tO\ntypical\tO\npresentation\tO\n,\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nbone\tO\nscans\tO\n.\tO\n\nThe\tO\nCalcineurin\tO\n-\tO\ninhibitor\tO\nInduced\tT-0\nPain\tO\nSyndrome\tO\n(\tO\nCIPS\tB-Disease\n)\tO\nis\tT-1\na\tT-1\nrare\tT-1\nbut\tO\nsevere\tO\nside\tO\neffect\tO\nof\tO\ncyclosporine\tO\nor\tO\ntacrolimus\tO\nand\tO\nis\tO\naccurately\tO\ndiagnosed\tO\nby\tO\nits\tO\ntypical\tO\npresentation\tO\n,\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nbone\tO\nscans\tO\n.\tO\n\nThe\tO\nCalcineurin\tO\n-\tO\ninhibitor\tO\nInduced\tO\nPain\tO\nSyndrome\tO\n(\tO\nCIPS\tO\n)\tO\nis\tO\na\tO\nrare\tO\nbut\tO\nsevere\tO\nside\tT-0\neffect\tT-0\nof\tT-0\ncyclosporine\tB-Chemical\nor\tO\ntacrolimus\tO\nand\tO\nis\tO\naccurately\tO\ndiagnosed\tO\nby\tO\nits\tO\ntypical\tO\npresentation\tO\n,\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nbone\tO\nscans\tO\n.\tO\n\nThe\tO\nCalcineurin\tO\n-\tO\ninhibitor\tO\nInduced\tT-0\nPain\tO\nSyndrome\tO\n(\tO\nCIPS\tO\n)\tO\nis\tO\na\tO\nrare\tO\nbut\tO\nsevere\tO\nside\tT-2\neffect\tT-2\nof\tT-2\ncyclosporine\tO\nor\tO\ntacrolimus\tB-Chemical\nand\tO\nis\tO\naccurately\tO\ndiagnosed\tT-1\nby\tT-1\nits\tO\ntypical\tO\npresentation\tO\n,\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nbone\tO\nscans\tO\n.\tO\n\nIncorrect\tO\ndiagnosis\tO\nof\tO\nthe\tO\nsyndrome\tO\nwill\tO\nlead\tO\nto\tO\na\tO\nsignificant\tO\nreduction\tO\nof\tO\nlife\tO\nquality\tO\nin\tO\npatients\tO\nsuffering\tT-0\nfrom\tT-0\nCIPS\tB-Disease\n.\tO\n\nBrain\tO\nnatriuretic\tO\npeptide\tO\nis\tO\na\tO\npredictor\tT-1\nof\tT-1\nanthracycline\tB-Chemical\n-\tO\ninduced\tT-2\ncardiotoxicity\tO\n.\tO\n\nBrain\tO\nnatriuretic\tO\npeptide\tO\nis\tO\na\tO\npredictor\tT-0\nof\tT-0\nanthracycline\tO\n-\tO\ninduced\tT-1\ncardiotoxicity\tB-Disease\n.\tO\n\nAnthracyclines\tB-Chemical\nare\tT-1\neffective\tT-1\nantineoplastic\tO\ndrugs\tO\n,\tO\nbut\tT-2\nthey\tT-2\nfrequently\tT-2\ncause\tT-2\ndose\tO\n-\tO\nrelated\tO\ncardiotoxicity\tO\n.\tO\n\nAnthracyclines\tO\nare\tO\neffective\tO\nantineoplastic\tO\ndrugs\tO\n,\tO\nbut\tO\nthey\tO\nfrequently\tO\ncause\tT-0\ndose\tO\n-\tO\nrelated\tO\ncardiotoxicity\tB-Disease\n.\tO\n\nThe\tT-0\ncardiotoxicity\tB-Disease\nof\tT-1\nconventional\tT-1\nanthracycline\tO\ntherapy\tO\nhighlights\tT-2\na\tO\nneed\tO\nto\tO\nsearch\tO\nfor\tO\nmethods\tO\nthat\tO\nare\tO\nhighly\tO\nsensitive\tO\nand\tO\ncapable\tO\nof\tO\npredicting\tO\ncardiac\tO\ndysfunction\tO\n.\tO\n\nThe\tO\ncardiotoxicity\tO\nof\tT-1\nconventional\tT-1\nanthracycline\tB-Chemical\ntherapy\tT-0\nhighlights\tT-0\na\tO\nneed\tO\nto\tO\nsearch\tO\nfor\tO\nmethods\tO\nthat\tO\nare\tO\nhighly\tO\nsensitive\tO\nand\tO\ncapable\tO\nof\tO\npredicting\tO\ncardiac\tO\ndysfunction\tO\n.\tO\n\nThe\tO\ncardiotoxicity\tO\nof\tO\nconventional\tO\nanthracycline\tO\ntherapy\tO\nhighlights\tO\na\tO\nneed\tO\nto\tO\nsearch\tO\nfor\tO\nmethods\tO\nthat\tO\nare\tO\nhighly\tO\nsensitive\tO\nand\tO\ncapable\tT-0\nof\tT-0\npredicting\tT-1\ncardiac\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nWe\tO\nmeasured\tO\nthe\tO\nplasma\tO\nlevel\tO\nof\tO\nbrain\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nBNP\tO\n)\tO\nto\tO\ndetermine\tO\nwhether\tO\nBNP\tO\nmight\tO\nserve\tO\nas\tO\na\tO\nsimple\tO\ndiagnostic\tO\nindicator\tT-1\nof\tT-1\nanthracycline\tB-Chemical\n-\tO\ninduced\tT-0\ncardiotoxicity\tO\nin\tO\npatients\tO\nwith\tO\nacute\tO\nleukemia\tO\ntreated\tO\nwith\tO\na\tO\ndaunorubicin\tO\n(\tO\nDNR\tO\n)\tO\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nWe\tO\nmeasured\tO\nthe\tO\nplasma\tO\nlevel\tO\nof\tO\nbrain\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nBNP\tO\n)\tO\nto\tO\ndetermine\tO\nwhether\tO\nBNP\tO\nmight\tO\nserve\tO\nas\tO\na\tO\nsimple\tO\ndiagnostic\tO\nindicator\tO\nof\tO\nanthracycline\tO\n-\tO\ninduced\tT-0\ncardiotoxicity\tB-Disease\nin\tT-1\npatients\tT-1\nwith\tO\nacute\tO\nleukemia\tO\ntreated\tO\nwith\tO\na\tO\ndaunorubicin\tO\n(\tO\nDNR\tO\n)\tO\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nWe\tO\nmeasured\tO\nthe\tO\nplasma\tO\nlevel\tO\nof\tO\nbrain\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nBNP\tO\n)\tO\nto\tO\ndetermine\tO\nwhether\tO\nBNP\tO\nmight\tO\nserve\tO\nas\tO\na\tO\nsimple\tO\ndiagnostic\tT-0\nindicator\tO\nof\tO\nanthracycline\tO\n-\tO\ninduced\tT-3\ncardiotoxicity\tO\nin\tO\npatients\tT-1\nwith\tO\nacute\tB-Disease\nleukemia\tI-Disease\ntreated\tT-4\nwith\tT-4\na\tO\ndaunorubicin\tO\n(\tO\nDNR\tO\n)\tO\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nWe\tO\nmeasured\tO\nthe\tO\nplasma\tO\nlevel\tO\nof\tO\nbrain\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nBNP\tO\n)\tO\nto\tO\ndetermine\tO\nwhether\tO\nBNP\tO\nmight\tO\nserve\tO\nas\tO\na\tO\nsimple\tO\ndiagnostic\tO\nindicator\tO\nof\tO\nanthracycline\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nin\tO\npatients\tO\nwith\tO\nacute\tO\nleukemia\tO\ntreated\tT-0\nwith\tT-0\na\tO\ndaunorubicin\tB-Chemical\n(\tO\nDNR\tO\n)\tO\n-\tO\ncontaining\tT-1\nregimen\tO\n.\tO\n\nWe\tO\nmeasured\tO\nthe\tO\nplasma\tO\nlevel\tO\nof\tO\nbrain\tO\nnatriuretic\tO\npeptide\tO\n(\tO\nBNP\tO\n)\tO\nto\tO\ndetermine\tO\nwhether\tO\nBNP\tO\nmight\tO\nserve\tO\nas\tO\na\tO\nsimple\tO\ndiagnostic\tO\nindicator\tO\nof\tO\nanthracycline\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nin\tT-0\npatients\tT-0\nwith\tO\nacute\tO\nleukemia\tO\ntreated\tT-1\nwith\tT-1\na\tO\ndaunorubicin\tO\n(\tO\nDNR\tB-Chemical\n)\tO\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nThirteen\tO\npatients\tT-0\nwith\tT-0\nacute\tB-Disease\nleukemia\tI-Disease\nwere\tO\ntreated\tT-1\nwith\tT-1\na\tO\nDNR\tO\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nThirteen\tO\npatients\tO\nwith\tO\nacute\tO\nleukemia\tO\nwere\tO\ntreated\tT-1\nwith\tT-1\na\tT-1\nDNR\tB-Chemical\n-\tO\ncontaining\tO\nregimen\tO\n.\tO\n\nThree\tO\npatients\tT-0\ndeveloped\tT-1\ncongestive\tB-Disease\nheart\tI-Disease\nfailure\tI-Disease\nafter\tO\nthe\tO\ncompletion\tO\nof\tO\nchemotherapy\tO\n.\tO\n\nFive\tO\npatients\tO\nwere\tO\ndiagnosed\tT-0\nas\tT-0\nhaving\tT-0\nsubclinical\tT-1\nheart\tB-Disease\nfailure\tI-Disease\nafter\tO\nthe\tO\ncompletion\tO\nof\tO\nchemotherapy\tO\n.\tO\n\nThe\tO\nplasma\tO\nlevels\tO\nof\tO\nBNP\tO\nin\tO\nall\tO\nthe\tO\npatients\tO\nwith\tO\nclinical\tO\nand\tO\nsubclinical\tT-0\nheart\tB-Disease\nfailure\tI-Disease\nincreased\tT-1\nabove\tT-1\nthe\tO\nnormal\tO\nlimit\tO\n(\tO\n40\tO\npg\tO\n/\tO\nml\tO\n)\tO\nbefore\tT-2\nthe\tT-2\ndetection\tT-2\nof\tO\nclinical\tO\nor\tO\nsubclinical\tO\nheart\tO\nfailure\tO\nby\tO\nradionuclide\tO\nangiography\tO\n.\tO\n\nThe\tO\nplasma\tO\nlevels\tO\nof\tO\nBNP\tO\nin\tO\nall\tO\nthe\tO\npatients\tO\nwith\tO\nclinical\tO\nand\tO\nsubclinical\tO\nheart\tO\nfailure\tO\nincreased\tT-0\nabove\tO\nthe\tO\nnormal\tO\nlimit\tO\n(\tO\n40\tO\npg\tO\n/\tO\nml\tO\n)\tO\nbefore\tO\nthe\tO\ndetection\tT-1\nof\tT-1\nclinical\tO\nor\tO\nsubclinical\tO\nheart\tB-Disease\nfailure\tI-Disease\nby\tO\nradionuclide\tO\nangiography\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nBNP\tO\ndid\tO\nnot\tO\nincrease\tT-1\nin\tO\nthe\tO\npatients\tO\nwithout\tT-0\nheart\tB-Disease\nfailure\tI-Disease\ngiven\tO\nDNR\tO\n,\tO\neven\tO\nat\tO\nmore\tO\nthan\tO\n700\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nBNP\tO\ndid\tO\nnot\tO\nincrease\tO\nin\tO\nthe\tO\npatients\tO\nwithout\tO\nheart\tO\nfailure\tO\ngiven\tT-0\nDNR\tB-Chemical\n,\tO\neven\tO\nat\tO\nmore\tO\nthan\tO\n700\tO\nmg\tO\n/\tO\nm\tO\n(\tO\n2\tO\n)\tO\n.\tO\n\nThe\tO\nplasma\tO\nlevel\tO\nof\tO\nANP\tO\ndid\tO\nnot\tO\nalways\tO\nincrease\tO\nin\tO\nall\tO\nthe\tO\npatients\tO\nwith\tO\nclinical\tT-0\nand\tT-0\nsubclinical\tT-0\nheart\tB-Disease\nfailure\tI-Disease\n.\tO\n\nThese\tO\npreliminary\tO\nresults\tO\nsuggest\tO\nthat\tO\nBNP\tO\nmay\tO\nbe\tO\nuseful\tO\nas\tO\nan\tO\nearly\tO\nand\tO\nsensitive\tO\nindicator\tT-0\nof\tT-0\nanthracycline\tB-Chemical\n-\tO\ninduced\tT-1\ncardiotoxicity\tO\n.\tO\n\nThese\tO\npreliminary\tO\nresults\tO\nsuggest\tO\nthat\tO\nBNP\tO\nmay\tO\nbe\tO\nuseful\tO\nas\tO\nan\tO\nearly\tO\nand\tO\nsensitive\tO\nindicator\tO\nof\tO\nanthracycline\tO\n-\tO\ninduced\tT-0\ncardiotoxicity\tB-Disease\n.\tO\n\nNephrotoxicity\tB-Disease\nof\tT-0\ncombined\tT-1\ncephalothin\tO\n-\tO\ngentamicin\tO\nregimen\tO\n.\tO\n\nNephrotoxicity\tO\nof\tT-1\ncombined\tT-1\ncephalothin\tB-Chemical\n-\tO\ngentamicin\tO\nregimen\tO\n.\tO\n\nNephrotoxicity\tO\nof\tO\ncombined\tO\ncephalothin\tT-0\n-\tT-0\ngentamicin\tB-Chemical\nregimen\tO\n.\tO\n\nTwo\tO\npatients\tT-2\ndeveloped\tT-2\nacute\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\n,\tO\ncharacterized\tO\nclinically\tO\nby\tO\nacute\tO\noliguric\tO\nrenal\tO\nfailure\tO\n,\tO\nwhile\tO\nthey\tO\nwere\tO\nreceiving\tO\na\tO\ncombination\tO\nof\tO\ncephalothin\tO\nsodium\tO\nand\tO\ngentamicin\tO\nsulfate\tO\ntherapy\tT-1\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tT-0\nacute\tO\ntubular\tO\nnecrosis\tO\n,\tO\ncharacterized\tO\nclinically\tO\nby\tT-3\nacute\tT-3\noliguric\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nwhile\tO\nthey\tO\nwere\tO\nreceiving\tT-1\na\tO\ncombination\tO\nof\tO\ncephalothin\tO\nsodium\tO\nand\tO\ngentamicin\tO\nsulfate\tO\ntherapy\tO\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tT-0\nacute\tO\ntubular\tO\nnecrosis\tO\n,\tO\ncharacterized\tO\nclinically\tO\nby\tO\nacute\tO\noliguric\tO\nrenal\tO\nfailure\tO\n,\tO\nwhile\tO\nthey\tO\nwere\tO\nreceiving\tO\na\tO\ncombination\tT-1\nof\tT-1\ncephalothin\tB-Chemical\nsodium\tI-Chemical\nand\tT-2\ngentamicin\tT-2\nsulfate\tT-2\ntherapy\tO\n.\tO\n\nTwo\tO\npatients\tT-1\ndeveloped\tT-2\nacute\tO\ntubular\tO\nnecrosis\tO\n,\tO\ncharacterized\tT-3\nclinically\tO\nby\tT-4\nacute\tO\noliguric\tO\nrenal\tO\nfailure\tO\n,\tO\nwhile\tO\nthey\tO\nwere\tO\nreceiving\tT-0\na\tO\ncombination\tO\nof\tO\ncephalothin\tO\nsodium\tO\nand\tO\ngentamicin\tB-Chemical\nsulfate\tI-Chemical\ntherapy\tT-5\n.\tO\n\nPatients\tO\nwho\tO\nare\tO\ngiven\tO\nthis\tO\ndrug\tO\nregimen\tO\nshould\tT-1\nbe\tT-1\nobserved\tT-1\nvery\tO\ncarefully\tO\nfor\tO\nearly\tT-2\nsigns\tT-2\nof\tT-2\nnephrotoxicity\tB-Disease\n.\tO\n\nPatients\tT-1\nwith\tT-1\nrenal\tB-Disease\ninsufficiency\tI-Disease\nshould\tO\nnot\tO\nbe\tT-0\ngiven\tT-0\nthis\tO\nregimen\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tT-0\napoptotic\tT-0\nand\tO\nnecrotic\tB-Disease\ncell\tT-2\ndeaths\tT-2\nduring\tO\nacetaminophen\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n-\tO\ninduced\tT-1\nlung\tO\ntoxicity\tO\nand\tO\ndoxorubicin\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nby\tO\na\tO\nnovel\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tO\napoptotic\tO\nand\tO\nnecrotic\tO\ncell\tO\ndeaths\tO\nduring\tO\nacetaminophen\tB-Chemical\n-\tT-0\ninduced\tT-0\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n-\tO\ninduced\tO\nlung\tO\ntoxicity\tO\nand\tO\ndoxorubicin\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nby\tO\na\tO\nnovel\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tO\napoptotic\tO\nand\tO\nnecrotic\tO\ncell\tO\ndeaths\tO\nduring\tO\nacetaminophen\tO\n-\tT-1\ninduced\tT-1\nnephrotoxicity\tB-Disease\n,\tT-2\namiodarone\tT-2\n-\tT-2\ninduced\tT-2\nlung\tO\ntoxicity\tO\nand\tO\ndoxorubicin\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nby\tO\na\tO\nnovel\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tO\napoptotic\tO\nand\tO\nnecrotic\tO\ncell\tO\ndeaths\tO\nduring\tO\nacetaminophen\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\namiodarone\tB-Chemical\n-\tO\ninduced\tT-1\nlung\tO\ntoxicity\tO\nand\tO\ndoxorubicin\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nby\tO\na\tO\nnovel\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tO\napoptotic\tO\nand\tO\nnecrotic\tO\ncell\tO\ndeaths\tO\nduring\tO\nacetaminophen\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n-\tO\ninduced\tT-1\nlung\tB-Disease\ntoxicity\tI-Disease\nand\tT-2\ndoxorubicin\tO\n-\tO\ninduced\tT-0\ncardiotoxicity\tO\nby\tO\na\tO\nnovel\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tO\napoptotic\tO\nand\tO\nnecrotic\tO\ncell\tO\ndeaths\tO\nduring\tT-1\nacetaminophen\tO\n-\tO\ninduced\tT-2\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n-\tO\ninduced\tT-3\nlung\tO\ntoxicity\tO\nand\tO\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tT-4\ncardiotoxicity\tO\nby\tO\na\tO\nnovel\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tO\napoptotic\tO\nand\tO\nnecrotic\tO\ncell\tO\ndeaths\tO\nduring\tO\nacetaminophen\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n-\tO\ninduced\tO\nlung\tO\ntoxicity\tO\nand\tO\ndoxorubicin\tO\n-\tO\ninduced\tT-0\ncardiotoxicity\tB-Disease\nby\tT-1\na\tT-1\nnovel\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n.\tO\n\nIn\tO\nvivo\tO\nprotection\tO\nof\tO\ndna\tO\ndamage\tO\nassociated\tT-0\napoptotic\tO\nand\tO\nnecrotic\tO\ncell\tO\ndeaths\tO\nduring\tO\nacetaminophen\tO\n-\tO\ninduced\tT-1\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n-\tO\ninduced\tT-2\nlung\tO\ntoxicity\tO\nand\tO\ndoxorubicin\tO\n-\tO\ninduced\tT-3\ncardiotoxicity\tO\nby\tO\na\tO\nnovel\tO\nIH636\tB-Chemical\ngrape\tI-Chemical\nseed\tI-Chemical\nproanthocyanidin\tI-Chemical\nextract\tI-Chemical\n.\tO\n\nGrape\tB-Chemical\nseed\tI-Chemical\nextract\tI-Chemical\n,\tO\nprimarily\tO\na\tO\nmixture\tO\nof\tO\nproanthocyanidins\tO\n,\tO\nhas\tT-1\nbeen\tT-1\nshown\tT-1\nto\tT-1\nmodulate\tO\na\tO\nwide\tO\n-\tO\nrange\tO\nof\tO\nbiological\tO\n,\tO\npharmacological\tO\nand\tO\ntoxicological\tO\neffects\tT-0\nwhich\tO\nare\tO\nmainly\tO\ncytoprotective\tO\n.\tO\n\nGrape\tO\nseed\tO\nextract\tO\n,\tO\nprimarily\tO\na\tO\nmixture\tT-0\nof\tT-0\nproanthocyanidins\tB-Chemical\n,\tO\nhas\tO\nbeen\tO\nshown\tO\nto\tO\nmodulate\tO\na\tO\nwide\tO\n-\tO\nrange\tO\nof\tO\nbiological\tO\n,\tO\npharmacological\tO\nand\tO\ntoxicological\tO\neffects\tO\nwhich\tO\nare\tO\nmainly\tO\ncytoprotective\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tT-0\nof\tT-0\nIH636\tB-Chemical\ngrape\tI-Chemical\nseed\tI-Chemical\nproanthocyanidin\tI-Chemical\nextract\tI-Chemical\n(\tO\nGSPE\tO\n)\tO\nto\tO\nprevent\tT-1\nacetaminophen\tO\n(\tO\nAAP\tO\n)\tO\n-\tO\ninduced\tT-2\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tT-3\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tT-4\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tT-2\nassessed\tT-2\nthe\tO\nability\tO\nof\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tT-0\n(\tO\nGSPE\tB-Chemical\n)\tO\nto\tT-1\nprevent\tT-1\nacetaminophen\tO\n(\tO\nAAP\tO\n)\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tO\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tT-3\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tO\nof\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n(\tO\nGSPE\tO\n)\tO\nto\tO\nprevent\tT-0\nacetaminophen\tB-Chemical\n(\tO\nAAP\tO\n)\tO\n-\tO\ninduced\tT-1\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tO\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tO\nof\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n(\tO\nGSPE\tO\n)\tO\nto\tT-2\nprevent\tT-2\nacetaminophen\tO\n(\tO\nAAP\tB-Chemical\n)\tO\n-\tO\ninduced\tT-3\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tT-1\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tO\nof\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n(\tO\nGSPE\tO\n)\tO\nto\tO\nprevent\tO\nacetaminophen\tO\n(\tO\nAAP\tO\n)\tO\n-\tT-1\ninduced\tT-1\nnephrotoxicity\tB-Disease\n,\tO\namiodarone\tO\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tO\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tT-0\nof\tT-0\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n(\tO\nGSPE\tO\n)\tO\nto\tT-1\nprevent\tT-1\nacetaminophen\tO\n(\tO\nAAP\tO\n)\tO\n-\tO\ninduced\tT-2\nnephrotoxicity\tO\n,\tO\namiodarone\tB-Chemical\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tT-3\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tO\nof\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n(\tO\nGSPE\tO\n)\tO\nto\tT-1\nprevent\tT-1\nacetaminophen\tO\n(\tO\nAAP\tO\n)\tO\n-\tO\ninduced\tT-2\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n(\tO\nAMI\tB-Chemical\n)\tO\n-\tO\ninduced\tT-0\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tO\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tT-0\nof\tT-0\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n(\tO\nGSPE\tO\n)\tO\nto\tT-1\nprevent\tT-1\nacetaminophen\tO\n(\tO\nAAP\tO\n)\tO\n-\tO\ninduced\tT-2\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tT-4\nlung\tB-Disease\ntoxicity\tI-Disease\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tT-3\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tO\nof\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n(\tO\nGSPE\tO\n)\tO\nto\tO\nprevent\tO\nacetaminophen\tO\n(\tO\nAAP\tO\n)\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tO\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tB-Chemical\n(\tT-1\nDOX\tT-1\n)\tT-1\n-\tT-1\ninduced\tT-1\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tO\nof\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n(\tO\nGSPE\tO\n)\tO\nto\tO\nprevent\tO\nacetaminophen\tO\n(\tO\nAAP\tO\n)\tO\n-\tO\ninduced\tT-0\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tT-1\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tB-Chemical\n)\tO\n-\tO\ninduced\tT-2\ncardiotoxicity\tO\nin\tO\nmice\tO\n.\tO\n\nThis\tO\nstudy\tO\nassessed\tO\nthe\tO\nability\tO\nof\tO\nIH636\tO\ngrape\tO\nseed\tO\nproanthocyanidin\tO\nextract\tO\n(\tO\nGSPE\tO\n)\tO\nto\tT-0\nprevent\tT-0\nacetaminophen\tO\n(\tO\nAAP\tO\n)\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\namiodarone\tO\n(\tO\nAMI\tO\n)\tO\n-\tO\ninduced\tO\nlung\tO\ntoxicity\tO\n,\tO\nand\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tT-1\ncardiotoxicity\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nExperimental\tO\ndesign\tO\nconsisted\tT-2\nof\tT-2\nfour\tO\ngroups\tO\n:\tO\ncontrol\tO\n(\tO\nvehicle\tO\nalone\tO\n)\tO\n,\tO\nGSPE\tB-Chemical\nalone\tT-1\n,\tO\ndrug\tO\nalone\tO\nand\tO\nGSPE\tO\n+\tO\ndrug\tO\n.\tO\n\nExperimental\tT-0\ndesign\tO\nconsisted\tO\nof\tO\nfour\tO\ngroups\tO\n:\tO\ncontrol\tO\n(\tO\nvehicle\tO\nalone\tO\n)\tO\n,\tO\nGSPE\tO\nalone\tO\n,\tO\ndrug\tO\nalone\tO\nand\tO\nGSPE\tB-Chemical\n+\tT-1\ndrug\tT-1\n.\tO\n\nFor\tO\nthe\tO\ncytoprotection\tO\nstudy\tO\n,\tO\nanimals\tO\nwere\tO\norally\tO\ngavaged\tO\n100\tT-0\nmg\tT-0\n/\tT-0\nKg\tT-0\nGSPE\tB-Chemical\nfor\tO\n7\tO\n-\tO\n10\tO\ndays\tO\nfollowed\tO\nby\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\nof\tO\norgan\tO\nspecific\tO\nthree\tO\ndrugs\tO\n(\tO\nAAP\tO\n:\tO\n500\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n24\tO\nh\tO\n;\tO\nAMI\tO\n:\tO\n50\tO\nmg\tO\n/\tO\nKg\tO\n/\tO\nday\tO\nfor\tO\nfour\tO\ndays\tO\n;\tO\nDOX\tO\n:\tO\n20\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n48\tO\nh\tO\n)\tO\n.\tO\n\nFor\tO\nthe\tO\ncytoprotection\tO\nstudy\tO\n,\tO\nanimals\tO\nwere\tO\norally\tT-2\ngavaged\tT-2\n100\tO\nmg\tO\n/\tO\nKg\tO\nGSPE\tO\nfor\tO\n7\tO\n-\tO\n10\tO\ndays\tO\nfollowed\tO\nby\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tT-3\nof\tO\norgan\tO\nspecific\tO\nthree\tO\ndrugs\tT-0\n(\tO\nAAP\tB-Chemical\n:\tO\n500\tT-1\nmg\tT-1\n/\tO\nKg\tO\nfor\tO\n24\tO\nh\tO\n;\tO\nAMI\tO\n:\tO\n50\tO\nmg\tO\n/\tO\nKg\tO\n/\tO\nday\tO\nfor\tO\nfour\tO\ndays\tO\n;\tO\nDOX\tO\n:\tO\n20\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n48\tO\nh\tO\n)\tO\n.\tO\n\nFor\tO\nthe\tO\ncytoprotection\tO\nstudy\tO\n,\tO\nanimals\tO\nwere\tO\norally\tO\ngavaged\tO\n100\tO\nmg\tO\n/\tO\nKg\tO\nGSPE\tO\nfor\tO\n7\tO\n-\tO\n10\tO\ndays\tO\nfollowed\tT-0\nby\tT-0\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\nof\tO\norgan\tO\nspecific\tO\nthree\tO\ndrugs\tO\n(\tO\nAAP\tO\n:\tO\n500\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n24\tO\nh\tO\n;\tO\nAMI\tB-Chemical\n:\tO\n50\tO\nmg\tO\n/\tO\nKg\tO\n/\tO\nday\tO\nfor\tO\nfour\tO\ndays\tO\n;\tO\nDOX\tO\n:\tO\n20\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n48\tO\nh\tO\n)\tO\n.\tO\n\nFor\tO\nthe\tO\ncytoprotection\tO\nstudy\tO\n,\tO\nanimals\tO\nwere\tO\norally\tT-0\ngavaged\tT-0\n100\tO\nmg\tO\n/\tO\nKg\tO\nGSPE\tO\nfor\tO\n7\tO\n-\tO\n10\tO\ndays\tO\nfollowed\tO\nby\tO\ni\tO\n.\tO\np\tO\n.\tO\ninjections\tO\nof\tO\norgan\tO\nspecific\tO\nthree\tO\ndrugs\tO\n(\tO\nAAP\tO\n:\tO\n500\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n24\tO\nh\tO\n;\tO\nAMI\tO\n:\tO\n50\tO\nmg\tO\n/\tO\nKg\tO\n/\tO\nday\tO\nfor\tO\nfour\tO\ndays\tO\n;\tO\nDOX\tB-Chemical\n:\tO\n20\tO\nmg\tO\n/\tO\nKg\tO\nfor\tO\n48\tO\nh\tO\n)\tO\n.\tO\n\nResults\tO\nindicate\tO\nthat\tO\nGSPE\tB-Chemical\npreexposure\tT-0\nprior\tO\nto\tO\nAAP\tO\n,\tO\nAMI\tO\nand\tO\nDOX\tO\n,\tO\nprovided\tO\nnear\tO\ncomplete\tO\nprotection\tO\nin\tO\nterms\tO\nof\tO\nserum\tO\nchemistry\tO\nchanges\tO\n(\tO\nALT\tO\n,\tO\nBUN\tO\nand\tO\nCPK\tO\n)\tO\n,\tO\nand\tO\nsignificantly\tO\nreduced\tO\nDNA\tO\nfragmentation\tO\n.\tO\n\nResults\tO\nindicate\tT-1\nthat\tO\nGSPE\tO\npreexposure\tT-2\nprior\tT-0\nto\tT-0\nAAP\tB-Chemical\n,\tO\nAMI\tO\nand\tO\nDOX\tO\n,\tO\nprovided\tO\nnear\tO\ncomplete\tO\nprotection\tO\nin\tO\nterms\tO\nof\tO\nserum\tO\nchemistry\tO\nchanges\tO\n(\tO\nALT\tO\n,\tO\nBUN\tO\nand\tO\nCPK\tO\n)\tO\n,\tO\nand\tO\nsignificantly\tO\nreduced\tT-3\nDNA\tO\nfragmentation\tO\n.\tO\n\nResults\tO\nindicate\tO\nthat\tO\nGSPE\tO\npreexposure\tT-0\nprior\tO\nto\tO\nAAP\tO\n,\tO\nAMI\tB-Chemical\nand\tO\nDOX\tO\n,\tO\nprovided\tO\nnear\tO\ncomplete\tO\nprotection\tO\nin\tO\nterms\tO\nof\tO\nserum\tO\nchemistry\tO\nchanges\tO\n(\tO\nALT\tO\n,\tO\nBUN\tO\nand\tO\nCPK\tO\n)\tO\n,\tO\nand\tO\nsignificantly\tO\nreduced\tO\nDNA\tO\nfragmentation\tO\n.\tO\n\nResults\tO\nindicate\tO\nthat\tO\nGSPE\tO\npreexposure\tT-0\nprior\tT-0\nto\tO\nAAP\tO\n,\tO\nAMI\tO\nand\tO\nDOX\tB-Chemical\n,\tO\nprovided\tO\nnear\tO\ncomplete\tO\nprotection\tO\nin\tO\nterms\tO\nof\tO\nserum\tO\nchemistry\tO\nchanges\tO\n(\tO\nALT\tO\n,\tO\nBUN\tO\nand\tO\nCPK\tO\n)\tO\n,\tO\nand\tO\nsignificantly\tO\nreduced\tO\nDNA\tO\nfragmentation\tO\n.\tO\n\nHistopathological\tO\nexamination\tO\nof\tO\nkidney\tO\n,\tO\nheart\tO\nand\tO\nlung\tO\nsections\tO\nrevealed\tO\nmoderate\tO\nto\tO\nmassive\tO\ntissue\tO\ndamage\tO\nwith\tO\na\tO\nvariety\tO\nof\tO\nmorphological\tO\naberrations\tO\nby\tO\nall\tO\nthe\tO\nthree\tO\ndrugs\tO\nin\tO\nthe\tO\nabsence\tT-0\nof\tT-0\nGSPE\tB-Chemical\npreexposure\tT-1\nthan\tO\nin\tO\nits\tO\npresence\tO\n.\tO\n\nGSPE\tB-Chemical\n+\tT-2\ndrug\tT-2\nexposed\tT-1\ntissues\tO\nexhibited\tT-0\nminor\tO\nresidual\tO\ndamage\tO\nor\tO\nnear\tO\ntotal\tO\nrecovery\tO\n.\tO\n\nInterestingly\tO\n,\tO\nall\tO\nthe\tO\ndrugs\tO\n,\tO\nsuch\tT-1\nas\tT-1\n,\tO\nAAP\tB-Chemical\n,\tO\nAMI\tO\nand\tO\nDOX\tO\ninduced\tT-0\napoptotic\tO\ndeath\tO\nin\tO\naddition\tO\nto\tO\nnecrosis\tO\nin\tO\nthe\tO\nrespective\tO\norgans\tO\nwhich\tO\nwas\tO\nvery\tO\neffectively\tO\nblocked\tO\nby\tO\nGSPE\tO\n.\tO\n\nInterestingly\tO\n,\tO\nall\tO\nthe\tO\ndrugs\tO\n,\tO\nsuch\tO\nas\tO\n,\tO\nAAP\tT-0\n,\tT-0\nAMI\tB-Chemical\nand\tT-1\nDOX\tT-1\ninduced\tO\napoptotic\tO\ndeath\tO\nin\tO\naddition\tO\nto\tO\nnecrosis\tO\nin\tO\nthe\tO\nrespective\tO\norgans\tO\nwhich\tO\nwas\tO\nvery\tO\neffectively\tO\nblocked\tO\nby\tO\nGSPE\tO\n.\tO\n\nInterestingly\tO\n,\tO\nall\tO\nthe\tO\ndrugs\tT-0\n,\tO\nsuch\tO\nas\tO\n,\tO\nAAP\tO\n,\tO\nAMI\tO\nand\tO\nDOX\tB-Chemical\ninduced\tT-1\napoptotic\tO\ndeath\tO\nin\tO\naddition\tO\nto\tO\nnecrosis\tO\nin\tO\nthe\tO\nrespective\tO\norgans\tO\nwhich\tO\nwas\tO\nvery\tO\neffectively\tT-2\nblocked\tO\nby\tO\nGSPE\tO\n.\tO\n\nInterestingly\tO\n,\tO\nall\tO\nthe\tO\ndrugs\tO\n,\tO\nsuch\tO\nas\tO\n,\tO\nAAP\tO\n,\tO\nAMI\tO\nand\tO\nDOX\tO\ninduced\tO\napoptotic\tO\ndeath\tO\nin\tO\naddition\tO\nto\tO\nnecrosis\tB-Disease\nin\tT-0\nthe\tT-0\nrespective\tT-0\norgans\tT-0\nwhich\tO\nwas\tO\nvery\tO\neffectively\tO\nblocked\tO\nby\tO\nGSPE\tO\n.\tO\n\nInterestingly\tO\n,\tO\nall\tO\nthe\tO\ndrugs\tO\n,\tO\nsuch\tO\nas\tO\n,\tO\nAAP\tO\n,\tO\nAMI\tO\nand\tO\nDOX\tO\ninduced\tT-0\napoptotic\tO\ndeath\tO\nin\tO\naddition\tO\nto\tO\nnecrosis\tO\nin\tO\nthe\tO\nrespective\tO\norgans\tO\nwhich\tO\nwas\tO\nvery\tO\neffectively\tO\nblocked\tT-1\nby\tT-1\nGSPE\tB-Chemical\n.\tO\n\nSince\tO\nAAP\tB-Chemical\n,\tT-0\nAMI\tT-0\nand\tT-0\nDOX\tT-0\nundergo\tO\nbiotransformation\tO\nand\tO\nare\tO\nknown\tO\nto\tO\nproduce\tO\ndamaging\tO\nradicals\tO\nin\tO\nvivo\tO\n,\tO\nthe\tO\nprotection\tO\nby\tO\nGSPE\tO\nmay\tO\nbe\tO\nlinked\tO\nto\tO\nboth\tO\ninhibition\tO\nof\tO\nmetabolism\tO\nand\tO\n/\tO\nor\tO\ndetoxification\tO\nof\tO\ncytotoxic\tO\nradicals\tO\n.\tO\n\nSince\tO\nAAP\tO\n,\tO\nAMI\tB-Chemical\nand\tO\nDOX\tO\nundergo\tO\nbiotransformation\tO\nand\tO\nare\tO\nknown\tO\nto\tT-0\nproduce\tT-0\ndamaging\tO\nradicals\tO\nin\tO\nvivo\tO\n,\tO\nthe\tO\nprotection\tO\nby\tO\nGSPE\tO\nmay\tO\nbe\tO\nlinked\tT-1\nto\tT-1\nboth\tO\ninhibition\tO\nof\tO\nmetabolism\tO\nand\tO\n/\tO\nor\tO\ndetoxification\tO\nof\tO\ncytotoxic\tO\nradicals\tO\n.\tO\n\nSince\tO\nAAP\tO\n,\tO\nAMI\tO\nand\tO\nDOX\tB-Chemical\nundergo\tO\nbiotransformation\tO\nand\tO\nare\tT-3\nknown\tT-3\nto\tT-3\nproduce\tT-0\ndamaging\tO\nradicals\tO\nin\tO\nvivo\tO\n,\tO\nthe\tO\nprotection\tT-1\nby\tT-1\nGSPE\tO\nmay\tO\nbe\tO\nlinked\tO\nto\tO\nboth\tO\ninhibition\tT-2\nof\tO\nmetabolism\tO\nand\tO\n/\tO\nor\tO\ndetoxification\tO\nof\tO\ncytotoxic\tO\nradicals\tO\n.\tO\n\nSince\tO\nAAP\tO\n,\tO\nAMI\tO\nand\tO\nDOX\tO\nundergo\tO\nbiotransformation\tO\nand\tO\nare\tO\nknown\tO\nto\tO\nproduce\tO\ndamaging\tO\nradicals\tO\nin\tO\nvivo\tO\n,\tO\nthe\tO\nprotection\tT-0\nby\tT-0\nGSPE\tB-Chemical\nmay\tO\nbe\tO\nlinked\tO\nto\tO\nboth\tO\ninhibition\tO\nof\tO\nmetabolism\tO\nand\tO\n/\tO\nor\tO\ndetoxification\tO\nof\tO\ncytotoxic\tO\nradicals\tO\n.\tO\n\nAdditionally\tO\n,\tO\nthis\tO\nmay\tO\nhave\tO\nbeen\tO\nthe\tO\nfirst\tO\nreport\tO\non\tO\nAMI\tB-Chemical\n-\tO\ninduced\tT-1\napoptotic\tO\ndeath\tO\nin\tO\nthe\tO\nlung\tO\ntissue\tO\n.\tO\n\nTaken\tO\ntogether\tO\n,\tO\nthese\tO\nevents\tO\nundoubtedly\tO\nestablish\tO\nGSPE\tB-Chemical\n'\tT-0\ns\tT-0\nabundant\tT-0\nbioavailability\tT-0\n,\tO\nand\tO\nthe\tO\npower\tO\nto\tO\ndefend\tO\nmultiple\tO\ntarget\tO\norgans\tO\nfrom\tO\ntoxic\tO\nassaults\tO\ninduced\tO\nby\tO\nstructurally\tO\ndiverse\tO\nand\tO\nfunctionally\tO\ndifferent\tO\nentities\tO\nin\tO\nvivo\tO\n.\tO\n\nAntidepressant\tB-Chemical\n-\tO\ninduced\tT-0\nmania\tO\nin\tT-1\nbipolar\tO\npatients\tO\n:\tO\nidentification\tO\nof\tO\nrisk\tO\nfactors\tO\n.\tO\n\nAntidepressant\tO\n-\tO\ninduced\tT-3\nmania\tB-Disease\nin\tO\nbipolar\tO\npatients\tO\n:\tO\nidentification\tT-1\nof\tT-1\nrisk\tT-2\nfactors\tT-2\n.\tO\n\nAntidepressant\tO\n-\tO\ninduced\tT-1\nmania\tO\nin\tO\nbipolar\tB-Disease\npatients\tT-0\n:\tO\nidentification\tT-2\nof\tO\nrisk\tO\nfactors\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nConcerns\tO\nabout\tO\npossible\tT-1\nrisks\tT-1\nof\tT-1\nswitching\tO\nto\tO\nmania\tB-Disease\nassociated\tT-0\nwith\tT-0\nantidepressants\tT-0\ncontinue\tO\nto\tO\ninterfere\tO\nwith\tO\nthe\tO\nestablishment\tO\nof\tO\nan\tO\noptimal\tO\ntreatment\tT-2\nparadigm\tO\nfor\tO\nbipolar\tO\ndepression\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nConcerns\tO\nabout\tO\npossible\tO\nrisks\tO\nof\tO\nswitching\tO\nto\tO\nmania\tO\nassociated\tT-2\nwith\tT-2\nantidepressants\tB-Chemical\ncontinue\tO\nto\tO\ninterfere\tT-0\nwith\tT-0\nthe\tO\nestablishment\tO\nof\tO\nan\tO\noptimal\tT-1\ntreatment\tT-1\nparadigm\tT-1\nfor\tO\nbipolar\tO\ndepression\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nConcerns\tO\nabout\tO\npossible\tO\nrisks\tO\nof\tO\nswitching\tO\nto\tO\nmania\tO\nassociated\tT-0\nwith\tT-0\nantidepressants\tO\ncontinue\tO\nto\tO\ninterfere\tO\nwith\tO\nthe\tO\nestablishment\tT-1\nof\tO\nan\tO\noptimal\tO\ntreatment\tT-2\nparadigm\tO\nfor\tT-3\nbipolar\tB-Disease\ndepression\tI-Disease\n.\tO\n\nMETHOD\tO\n:\tO\nThe\tO\nresponse\tT-0\nof\tT-0\n44\tO\npatients\tT-1\nmeeting\tO\nDSM\tO\n-\tO\nIV\tO\ncriteria\tO\nfor\tO\nbipolar\tB-Disease\ndisorder\tI-Disease\nto\tO\nnaturalistic\tO\ntreatment\tT-2\nwas\tO\nassessed\tO\nfor\tO\nat\tO\nleast\tO\n6\tO\nweeks\tO\nusing\tO\nthe\tO\nMontgomery\tO\n-\tO\nAsberg\tO\nDepression\tO\nRating\tO\nScale\tO\nand\tO\nthe\tO\nBech\tO\n-\tO\nRafaelson\tO\nMania\tO\nRating\tO\nScale\tO\n.\tO\n\nPatients\tT-1\nwho\tT-1\nexperienced\tT-1\na\tT-1\nmanic\tB-Disease\nor\tT-2\nhypomanic\tT-2\nswitch\tT-2\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tO\n-\tO\nIV\tO\nbipolar\tO\nI\tO\nvs\tO\n.\tO\nbipolar\tO\nII\tO\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tO\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tO\ntherapy\tO\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tO\ndrugs\tO\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\n[\tO\nSSRIs\tO\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tO\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tT-0\nduring\tT-0\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tO\na\tO\nmanic\tT-1\nor\tT-1\nhypomanic\tB-Disease\nswitch\tT-0\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tO\n-\tO\nIV\tO\nbipolar\tO\nI\tO\nvs\tO\n.\tO\nbipolar\tO\nII\tO\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tO\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tO\ntherapy\tO\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tO\ndrugs\tO\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\n[\tO\nSSRIs\tO\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tO\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tO\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tT-1\na\tO\nmanic\tO\nor\tO\nhypomanic\tO\nswitch\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tB-Disease\n-\tI-Disease\nIV\tI-Disease\nbipolar\tI-Disease\nI\tI-Disease\nvs\tO\n.\tO\nbipolar\tO\nII\tO\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tO\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tO\ntherapy\tO\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tO\ndrugs\tO\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\n[\tO\nSSRIs\tO\n]\tO\n)\tO\n,\tO\nuse\tT-0\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tO\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tO\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tO\na\tO\nmanic\tO\nor\tO\nhypomanic\tO\nswitch\tO\nwere\tT-0\ncompared\tT-0\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tT-1\n(\tO\nDSM\tO\n-\tO\nIV\tO\nbipolar\tO\nI\tO\nvs\tO\n.\tO\nbipolar\tB-Disease\nII\tI-Disease\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tO\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tO\ntherapy\tO\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tO\ndrugs\tO\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\n[\tO\nSSRIs\tO\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tO\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tO\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tO\na\tO\nmanic\tO\nor\tO\nhypomanic\tO\nswitch\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tO\n-\tO\nIV\tO\nbipolar\tO\nI\tO\nvs\tO\n.\tO\nbipolar\tO\nII\tO\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tB-Disease\nepisodes\tT-0\n,\tO\ntype\tO\nof\tO\nantidepressant\tO\ntherapy\tO\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tO\ndrugs\tO\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\n[\tO\nSSRIs\tO\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tO\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tO\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tO\na\tO\nmanic\tO\nor\tO\nhypomanic\tO\nswitch\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tO\n-\tO\nIV\tO\nbipolar\tO\nI\tO\nvs\tO\n.\tO\nbipolar\tO\nII\tO\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tO\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tB-Chemical\ntherapy\tT-0\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tO\ndrugs\tO\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\n[\tO\nSSRIs\tO\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tO\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tO\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tO\na\tO\nmanic\tO\nor\tO\nhypomanic\tO\nswitch\tO\nwere\tO\ncompared\tT-1\nwith\tT-1\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tO\n-\tO\nIV\tO\nbipolar\tO\nI\tO\nvs\tO\n.\tO\nbipolar\tO\nII\tO\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tO\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tO\ntherapy\tO\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tB-Chemical\ndrugs\tT-0\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\n[\tO\nSSRIs\tO\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tO\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tO\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tO\na\tO\nmanic\tO\nor\tO\nhypomanic\tO\nswitch\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tO\n-\tO\nIV\tO\nbipolar\tO\nI\tO\nvs\tO\n.\tO\nbipolar\tO\nII\tO\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tO\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tO\ntherapy\tT-1\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tT-2\ndrugs\tT-2\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tT-3\nserotonin\tT-3\nreuptake\tT-3\ninhibitors\tT-3\n[\tO\nSSRIs\tB-Chemical\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tO\nstabilizers\tO\n(\tO\nlithium\tO\nvs\tO\n.\tO\nanticonvulsants\tO\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tT-0\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nPatients\tO\nwho\tO\nexperienced\tO\na\tO\nmanic\tO\nor\tO\nhypomanic\tO\nswitch\tO\nwere\tO\ncompared\tO\nwith\tO\nthose\tO\nwho\tO\ndid\tO\nnot\tO\non\tO\nseveral\tO\nvariables\tO\nincluding\tO\nage\tO\n,\tO\nsex\tO\n,\tO\ndiagnosis\tO\n(\tO\nDSM\tO\n-\tO\nIV\tO\nbipolar\tO\nI\tO\nvs\tO\n.\tO\nbipolar\tO\nII\tO\n)\tO\n,\tO\nnumber\tO\nof\tO\nprevious\tO\nmanic\tO\nepisodes\tO\n,\tO\ntype\tO\nof\tO\nantidepressant\tO\ntherapy\tO\nused\tO\n(\tO\nelectroconvulsive\tO\ntherapy\tO\nvs\tO\n.\tO\nantidepressant\tO\ndrugs\tO\nand\tO\n,\tO\nmore\tO\nparticularly\tO\n,\tO\nselective\tO\nserotonin\tO\nreuptake\tO\ninhibitors\tO\n[\tO\nSSRIs\tO\n]\tO\n)\tO\n,\tO\nuse\tO\nand\tO\ntype\tO\nof\tO\nmood\tT-1\nstabilizers\tT-1\n(\tO\nlithium\tB-Chemical\nvs\tT-0\n.\tT-0\nanticonvulsants\tT-0\n)\tO\n,\tO\nand\tO\ntemperament\tO\nof\tO\nthe\tO\npatient\tO\n,\tO\nassessed\tO\nduring\tO\na\tO\nnormothymic\tO\nperiod\tO\nusing\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemi\tO\n-\tO\nstructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSwitches\tT-0\nto\tT-0\nhypomania\tB-Disease\nor\tO\nmania\tO\noccurred\tO\nin\tO\n27\tO\n%\tO\nof\tO\nall\tO\npatients\tO\n(\tO\nN\tO\n=\tO\n12\tO\n)\tO\n(\tO\nand\tO\nin\tO\n24\tO\n%\tO\nof\tO\nthe\tO\nsubgroup\tO\nof\tO\npatients\tO\ntreated\tO\nwith\tO\nSSRIs\tO\n[\tO\n8\tO\n/\tO\n33\tO\n]\tO\n)\tO\n;\tO\n16\tO\n%\tO\n(\tO\nN\tO\n=\tO\n7\tO\n)\tO\nexperienced\tO\nmanic\tO\nepisodes\tO\n,\tO\nand\tO\n11\tO\n%\tO\n(\tO\nN\tO\n=\tO\n5\tO\n)\tO\nexperienced\tT-1\nhypomanic\tO\nepisodes\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSwitches\tO\nto\tO\nhypomania\tO\nor\tO\nmania\tB-Disease\noccurred\tT-4\nin\tT-4\n27\tO\n%\tO\nof\tO\nall\tO\npatients\tT-1\n(\tO\nN\tO\n=\tO\n12\tO\n)\tO\n(\tO\nand\tO\nin\tO\n24\tO\n%\tO\nof\tO\nthe\tO\nsubgroup\tO\nof\tO\npatients\tT-2\ntreated\tT-2\nwith\tT-2\nSSRIs\tO\n[\tO\n8\tO\n/\tO\n33\tO\n]\tO\n)\tO\n;\tO\n16\tO\n%\tO\n(\tO\nN\tO\n=\tO\n7\tO\n)\tO\nexperienced\tT-3\nmanic\tO\nepisodes\tO\n,\tO\nand\tO\n11\tO\n%\tO\n(\tO\nN\tO\n=\tO\n5\tO\n)\tO\nexperienced\tO\nhypomanic\tO\nepisodes\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSwitches\tO\nto\tO\nhypomania\tO\nor\tO\nmania\tO\noccurred\tT-0\nin\tO\n27\tO\n%\tO\nof\tO\nall\tO\npatients\tO\n(\tO\nN\tO\n=\tO\n12\tO\n)\tO\n(\tO\nand\tO\nin\tO\n24\tO\n%\tO\nof\tO\nthe\tO\nsubgroup\tO\nof\tO\npatients\tO\ntreated\tT-2\nwith\tT-2\nSSRIs\tB-Chemical\n[\tO\n8\tO\n/\tO\n33\tO\n]\tO\n)\tO\n;\tO\n16\tO\n%\tO\n(\tO\nN\tO\n=\tO\n7\tO\n)\tO\nexperienced\tT-1\nmanic\tO\nepisodes\tO\n,\tO\nand\tO\n11\tO\n%\tO\n(\tO\nN\tO\n=\tO\n5\tO\n)\tO\nexperienced\tO\nhypomanic\tO\nepisodes\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSwitches\tO\nto\tO\nhypomania\tO\nor\tO\nmania\tO\noccurred\tO\nin\tO\n27\tO\n%\tO\nof\tO\nall\tO\npatients\tO\n(\tO\nN\tO\n=\tO\n12\tO\n)\tO\n(\tO\nand\tO\nin\tO\n24\tO\n%\tO\nof\tO\nthe\tO\nsubgroup\tO\nof\tO\npatients\tO\ntreated\tO\nwith\tO\nSSRIs\tO\n[\tO\n8\tO\n/\tO\n33\tO\n]\tO\n)\tO\n;\tO\n16\tO\n%\tO\n(\tO\nN\tO\n=\tO\n7\tO\n)\tO\nexperienced\tT-0\nmanic\tB-Disease\nepisodes\tT-1\n,\tO\nand\tO\n11\tO\n%\tO\n(\tO\nN\tO\n=\tO\n5\tO\n)\tO\nexperienced\tO\nhypomanic\tO\nepisodes\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSwitches\tO\nto\tO\nhypomania\tO\nor\tO\nmania\tO\noccurred\tO\nin\tO\n27\tO\n%\tO\nof\tO\nall\tO\npatients\tO\n(\tO\nN\tO\n=\tO\n12\tO\n)\tO\n(\tO\nand\tO\nin\tO\n24\tO\n%\tO\nof\tO\nthe\tO\nsubgroup\tO\nof\tO\npatients\tO\ntreated\tO\nwith\tO\nSSRIs\tO\n[\tO\n8\tO\n/\tO\n33\tO\n]\tO\n)\tO\n;\tO\n16\tO\n%\tO\n(\tO\nN\tO\n=\tO\n7\tO\n)\tO\nexperienced\tO\nmanic\tO\nepisodes\tO\n,\tO\nand\tO\n11\tO\n%\tO\n(\tO\nN\tO\n=\tO\n5\tO\n)\tO\nexperienced\tT-0\nhypomanic\tB-Disease\nepisodes\tT-1\n.\tO\n\nSex\tO\n,\tO\nage\tO\n,\tO\ndiagnosis\tT-1\n(\tO\nbipolar\tB-Disease\nI\tI-Disease\nvs\tT-2\n.\tT-2\nbipolar\tT-2\nII\tT-2\n)\tO\n,\tO\nand\tO\nadditional\tO\ntreatment\tT-0\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nrisk\tO\nof\tO\nswitching\tO\n.\tO\n\nSex\tO\n,\tO\nage\tO\n,\tO\ndiagnosis\tT-0\n(\tT-0\nbipolar\tT-0\nI\tT-0\nvs\tT-0\n.\tT-0\nbipolar\tB-Disease\nII\tI-Disease\n)\tO\n,\tT-1\nand\tT-1\nadditional\tT-1\ntreatment\tT-1\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nrisk\tO\nof\tO\nswitching\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nmood\tO\nswitches\tO\nwere\tO\nless\tO\nfrequent\tO\nin\tO\npatients\tT-0\nreceiving\tT-1\nlithium\tB-Chemical\n(\tO\n15\tO\n%\tO\n,\tO\n4\tO\n/\tO\n26\tO\n)\tO\nthan\tO\nin\tO\npatients\tO\nnot\tT-2\ntreated\tT-2\nwith\tT-2\nlithium\tO\n(\tO\n44\tO\n%\tO\n,\tO\n8\tO\n/\tO\n18\tO\n;\tO\np\tO\n=\tO\n.\tO\n04\tO\n)\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nmood\tO\nswitches\tO\nwere\tO\nless\tO\nfrequent\tO\nin\tO\npatients\tO\nreceiving\tO\nlithium\tO\n(\tO\n15\tO\n%\tO\n,\tO\n4\tO\n/\tO\n26\tO\n)\tO\nthan\tO\nin\tO\npatients\tO\nnot\tO\ntreated\tT-1\nwith\tT-1\nlithium\tB-Chemical\n(\tT-0\n44\tT-0\n%\tT-0\n,\tT-0\n8\tT-0\n/\tT-0\n18\tT-0\n;\tT-0\np\tT-0\n=\tT-0\n.\tT-0\n04\tT-0\n)\tT-0\n.\tO\n\nThe\tO\nnumber\tO\nof\tT-0\nprevious\tT-0\nmanic\tB-Disease\nepisodes\tT-1\ndid\tO\nnot\tO\naffect\tO\nthe\tO\nprobability\tO\nof\tO\nswitching\tO\n,\tO\nwhereas\tO\na\tO\nhigh\tO\nscore\tO\non\tO\nthe\tO\nhyperthymia\tO\ncomponent\tO\nof\tO\nthe\tO\nSemistructured\tO\nAffective\tO\nTemperament\tO\nInterview\tO\nwas\tO\nassociated\tO\nwith\tO\na\tO\ngreater\tO\nrisk\tO\nof\tO\nswitching\tO\n(\tO\np\tO\n=\tO\n.\tO\n008\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nfrequency\tO\nof\tO\nmood\tO\nswitching\tO\nassociated\tT-0\nwith\tT-0\nacute\tT-2\nantidepressant\tB-Chemical\ntherapy\tT-1\nmay\tO\nbe\tO\nreduced\tO\nby\tO\nlithium\tO\ntreatment\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\nfrequency\tO\nof\tO\nmood\tO\nswitching\tO\nassociated\tO\nwith\tO\nacute\tO\nantidepressant\tO\ntherapy\tO\nmay\tO\nbe\tO\nreduced\tT-0\nby\tT-0\nlithium\tB-Chemical\ntreatment\tO\n.\tO\n\nPeritubular\tO\ncapillary\tO\nbasement\tO\nmembrane\tO\nreduplication\tO\nin\tO\nallografts\tO\nand\tO\nnative\tT-0\nkidney\tB-Disease\ndisease\tI-Disease\n:\tO\na\tO\nclinicopathologic\tO\nstudy\tT-1\nof\tT-1\n278\tO\nconsecutive\tO\nrenal\tO\nspecimens\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAn\tO\nassociation\tO\nhas\tO\nbeen\tO\nfound\tO\nbetween\tO\ntransplant\tB-Disease\nglomerulopathy\tI-Disease\n(\tO\nTG\tO\n)\tO\nand\tO\nreduplication\tT-0\nof\tO\nperitubular\tO\ncapillary\tO\nbasement\tO\nmembranes\tO\n(\tO\nPTCR\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nAn\tO\nassociation\tO\nhas\tO\nbeen\tO\nfound\tO\nbetween\tO\ntransplant\tO\nglomerulopathy\tT-1\n(\tO\nTG\tB-Disease\n)\tO\nand\tO\nreduplication\tT-0\nof\tO\nperitubular\tO\ncapillary\tO\nbasement\tO\nmembranes\tO\n(\tO\nPTCR\tO\n)\tO\n.\tO\n\nIn\tT-2\naddition\tT-2\nto\tT-2\nrenal\tO\nallografts\tO\nwith\tT-0\nTG\tB-Disease\n,\tO\nwe\tO\nalso\tO\nexamined\tT-1\ngrafts\tO\nwith\tO\nacute\tO\nrejection\tO\n,\tO\nrecurrent\tO\nglomerulonephritis\tO\n,\tO\nchronic\tO\nallograft\tO\nnephropathy\tO\nand\tO\nstable\tO\ngrafts\tO\n(\tO\n\"\tO\nprotocol\tO\nbiopsies\tO\n\"\tO\n)\tO\n.\tO\n\nIn\tT-4\naddition\tT-4\nto\tT-4\nrenal\tO\nallografts\tO\nwith\tO\nTG\tO\n,\tO\nwe\tO\nalso\tO\nexamined\tO\ngrafts\tO\nwith\tO\nacute\tO\nrejection\tT-1\n,\tO\nrecurrent\tT-2\nglomerulonephritis\tB-Disease\n,\tO\nchronic\tO\nallograft\tO\nnephropathy\tO\nand\tO\nstable\tT-3\ngrafts\tO\n(\tO\n\"\tO\nprotocol\tO\nbiopsies\tO\n\"\tO\n)\tO\n.\tO\n\nIn\tO\naddition\tO\nto\tO\nrenal\tO\nallografts\tO\nwith\tO\nTG\tO\n,\tO\nwe\tO\nalso\tO\nexamined\tT-0\ngrafts\tO\nwith\tO\nacute\tO\nrejection\tO\n,\tO\nrecurrent\tT-1\nglomerulonephritis\tO\n,\tO\nchronic\tB-Disease\nallograft\tI-Disease\nnephropathy\tI-Disease\nand\tO\nstable\tT-2\ngrafts\tO\n(\tO\n\"\tO\nprotocol\tO\nbiopsies\tO\n\"\tO\n)\tO\n.\tO\n\nNative\tO\nkidney\tO\nspecimens\tT-2\nincluded\tT-2\na\tT-2\nwide\tT-2\nrange\tT-2\nof\tT-1\nglomerulopathies\tB-Disease\nas\tT-0\nwell\tT-0\nas\tT-0\ncases\tT-0\nof\tO\nthrombotic\tO\nmicroangiopathy\tO\n,\tO\nmalignant\tO\nhypertension\tO\n,\tO\nacute\tO\ninterstitial\tO\nnephritis\tO\n,\tO\nand\tO\nacute\tO\ntubular\tO\nnecrosis\tO\n.\tO\n\nNative\tO\nkidney\tO\nspecimens\tO\nincluded\tT-2\na\tO\nwide\tO\nrange\tO\nof\tO\nglomerulopathies\tO\nas\tO\nwell\tO\nas\tO\ncases\tT-1\nof\tT-1\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n,\tO\nmalignant\tT-0\nhypertension\tT-0\n,\tO\nacute\tO\ninterstitial\tO\nnephritis\tO\n,\tO\nand\tO\nacute\tO\ntubular\tO\nnecrosis\tO\n.\tO\n\nNative\tO\nkidney\tO\nspecimens\tO\nincluded\tO\na\tO\nwide\tO\nrange\tO\nof\tO\nglomerulopathies\tO\nas\tO\nwell\tO\nas\tO\ncases\tT-2\nof\tT-2\nthrombotic\tT-0\nmicroangiopathy\tT-0\n,\tT-0\nmalignant\tB-Disease\nhypertension\tI-Disease\n,\tT-1\nacute\tT-1\ninterstitial\tT-1\nnephritis\tT-1\n,\tO\nand\tO\nacute\tO\ntubular\tO\nnecrosis\tO\n.\tO\n\nNative\tO\nkidney\tO\nspecimens\tO\nincluded\tO\na\tO\nwide\tO\nrange\tO\nof\tO\nglomerulopathies\tO\nas\tO\nwell\tO\nas\tO\ncases\tO\nof\tO\nthrombotic\tO\nmicroangiopathy\tO\n,\tO\nmalignant\tO\nhypertension\tO\n,\tO\nacute\tT-0\ninterstitial\tB-Disease\nnephritis\tI-Disease\n,\tO\nand\tO\nacute\tO\ntubular\tO\nnecrosis\tO\n.\tO\n\nNative\tO\nkidney\tO\nspecimens\tO\nincluded\tO\na\tO\nwide\tO\nrange\tO\nof\tO\nglomerulopathies\tO\nas\tO\nwell\tO\nas\tO\ncases\tO\nof\tO\nthrombotic\tO\nmicroangiopathy\tO\n,\tO\nmalignant\tO\nhypertension\tO\n,\tO\nacute\tO\ninterstitial\tO\nnephritis\tO\n,\tO\nand\tT-0\nacute\tB-Disease\ntubular\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nfound\tT-0\nPTCR\tO\nin\tO\n14\tO\nof\tO\n15\tO\ncases\tO\nof\tT-1\nTG\tB-Disease\n,\tO\nin\tO\n7\tO\ntransplant\tO\nbiopsy\tO\nspecimens\tO\nwithout\tO\nTG\tO\n,\tO\nand\tO\nin\tO\n13\tO\nof\tO\n143\tO\nnative\tO\nkidney\tO\nbiopsy\tO\nspecimens\tO\n.\tO\n\nRESULTS\tO\n:\tO\nWe\tO\nfound\tO\nPTCR\tO\nin\tO\n14\tO\nof\tO\n15\tO\ncases\tO\nof\tO\nTG\tO\n,\tO\nin\tO\n7\tO\ntransplant\tO\nbiopsy\tO\nspecimens\tT-0\nwithout\tT-0\nTG\tB-Disease\n,\tO\nand\tO\nin\tO\n13\tO\nof\tO\n143\tO\nnative\tO\nkidney\tO\nbiopsy\tO\nspecimens\tO\n.\tO\n\nThese\tO\n13\tO\nincluded\tO\ncases\tT-1\nof\tT-1\nmalignant\tB-Disease\nhypertension\tI-Disease\n,\tT-0\nthrombotic\tT-0\nmicroangiopathy\tT-0\n,\tO\nlupus\tO\nnephritis\tO\n,\tO\nHenoch\tO\n-\tO\nSchonlein\tO\nnephritis\tO\n,\tO\ncrescentic\tO\nglomerulonephritis\tO\n,\tO\nand\tO\ncocaine\tO\n-\tO\nrelated\tO\nacute\tO\nrenal\tO\nfailure\tO\n.\tO\n\nThese\tO\n13\tO\nincluded\tT-2\ncases\tO\nof\tO\nmalignant\tT-0\nhypertension\tT-0\n,\tT-0\nthrombotic\tB-Disease\nmicroangiopathy\tI-Disease\n,\tT-1\nlupus\tT-1\nnephritis\tT-1\n,\tO\nHenoch\tO\n-\tO\nSchonlein\tO\nnephritis\tO\n,\tO\ncrescentic\tO\nglomerulonephritis\tO\n,\tO\nand\tO\ncocaine\tO\n-\tO\nrelated\tO\nacute\tO\nrenal\tO\nfailure\tO\n.\tO\n\nThese\tO\n13\tO\nincluded\tO\ncases\tO\nof\tO\nmalignant\tO\nhypertension\tO\n,\tO\nthrombotic\tT-0\nmicroangiopathy\tT-0\n,\tT-0\nlupus\tB-Disease\nnephritis\tI-Disease\n,\tO\nHenoch\tO\n-\tO\nSchonlein\tO\nnephritis\tO\n,\tO\ncrescentic\tO\nglomerulonephritis\tO\n,\tO\nand\tO\ncocaine\tO\n-\tO\nrelated\tO\nacute\tO\nrenal\tO\nfailure\tO\n.\tO\n\nThese\tO\n13\tO\nincluded\tO\ncases\tT-1\nof\tT-1\nmalignant\tO\nhypertension\tO\n,\tO\nthrombotic\tO\nmicroangiopathy\tO\n,\tO\nlupus\tO\nnephritis\tO\n,\tO\nHenoch\tO\n-\tO\nSchonlein\tO\nnephritis\tO\n,\tO\ncrescentic\tT-0\nglomerulonephritis\tB-Disease\n,\tO\nand\tO\ncocaine\tO\n-\tO\nrelated\tO\nacute\tO\nrenal\tO\nfailure\tO\n.\tO\n\nThese\tO\n13\tO\nincluded\tO\ncases\tO\nof\tO\nmalignant\tO\nhypertension\tO\n,\tO\nthrombotic\tO\nmicroangiopathy\tO\n,\tO\nlupus\tO\nnephritis\tO\n,\tO\nHenoch\tO\n-\tO\nSchonlein\tO\nnephritis\tO\n,\tO\ncrescentic\tO\nglomerulonephritis\tO\n,\tO\nand\tT-0\ncocaine\tB-Chemical\n-\tO\nrelated\tT-1\nacute\tO\nrenal\tO\nfailure\tO\n.\tO\n\nThese\tO\n13\tO\nincluded\tO\ncases\tO\nof\tO\nmalignant\tO\nhypertension\tO\n,\tO\nthrombotic\tO\nmicroangiopathy\tO\n,\tO\nlupus\tO\nnephritis\tO\n,\tO\nHenoch\tO\n-\tO\nSchonlein\tO\nnephritis\tO\n,\tO\ncrescentic\tO\nglomerulonephritis\tO\n,\tO\nand\tO\ncocaine\tO\n-\tO\nrelated\tT-0\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n.\tO\n\nMild\tO\nPTCR\tO\nin\tO\nallografts\tO\nwithout\tT-0\nTG\tB-Disease\ndid\tO\nnot\tO\npredict\tO\nrenal\tO\nfailure\tO\nor\tO\nsignificant\tO\nproteinuria\tO\nafter\tO\nfollow\tO\n-\tO\nup\tO\nperiods\tO\nof\tO\nbetween\tO\n3\tO\nmonths\tO\nand\tO\n1\tO\nyear\tO\n.\tO\n\nMild\tO\nPTCR\tO\nin\tO\nallografts\tO\nwithout\tO\nTG\tO\ndid\tT-1\nnot\tT-1\npredict\tT-1\nrenal\tB-Disease\nfailure\tI-Disease\nor\tO\nsignificant\tO\nproteinuria\tO\nafter\tO\nfollow\tO\n-\tO\nup\tO\nperiods\tO\nof\tO\nbetween\tO\n3\tO\nmonths\tO\nand\tO\n1\tO\nyear\tO\n.\tO\n\nMild\tO\nPTCR\tO\nin\tO\nallografts\tO\nwithout\tO\nTG\tO\ndid\tO\nnot\tO\npredict\tT-0\nrenal\tO\nfailure\tO\nor\tO\nsignificant\tO\nproteinuria\tB-Disease\nafter\tO\nfollow\tO\n-\tO\nup\tO\nperiods\tO\nof\tO\nbetween\tO\n3\tO\nmonths\tO\nand\tO\n1\tO\nyear\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nconclude\tO\nthat\tO\nin\tO\ntransplants\tO\n,\tO\nthere\tO\nis\tO\na\tO\nstrong\tO\nassociation\tT-0\nbetween\tT-0\nwell\tO\n-\tO\ndeveloped\tO\nPTCR\tO\nand\tO\nTG\tB-Disease\n,\tO\nwhile\tO\nthe\tO\nsignificance\tO\nof\tO\nmild\tO\nPTCR\tO\nand\tO\nits\tO\npredictive\tT-1\nvalue\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nTG\tO\nis\tO\nunclear\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nconclude\tO\nthat\tO\nin\tO\ntransplants\tO\n,\tO\nthere\tO\nis\tO\na\tO\nstrong\tO\nassociation\tT-0\nbetween\tO\nwell\tO\n-\tO\ndeveloped\tO\nPTCR\tO\nand\tO\nTG\tO\n,\tO\nwhile\tO\nthe\tO\nsignificance\tO\nof\tO\nmild\tO\nPTCR\tO\nand\tO\nits\tO\npredictive\tT-1\nvalue\tO\nin\tO\nthe\tO\nabsence\tT-2\nof\tT-2\nTG\tB-Disease\nis\tO\nunclear\tO\n.\tO\n\nPTCR\tO\nalso\tO\noccurs\tT-0\nin\tT-0\ncertain\tO\nnative\tO\nkidney\tB-Disease\ndiseases\tI-Disease\n,\tO\nthough\tO\nthe\tO\nassociation\tT-1\nis\tO\nnot\tO\nas\tO\nstrong\tO\nas\tO\nthat\tO\nfor\tO\nTG\tO\n.\tO\n\nPTCR\tO\nalso\tO\noccurs\tO\nin\tO\ncertain\tO\nnative\tO\nkidney\tO\ndiseases\tO\n,\tO\nthough\tO\nthe\tO\nassociation\tO\nis\tO\nnot\tO\nas\tO\nstrong\tO\nas\tO\nthat\tT-0\nfor\tT-0\nTG\tB-Disease\n.\tO\n\nWe\tO\nsuggest\tT-0\nthat\tT-0\nrepeated\tO\nendothelial\tB-Disease\ninjury\tI-Disease\n,\tT-2\nincluding\tT-2\nimmunologic\tT-2\ninjury\tT-2\n,\tO\nmay\tT-1\nbe\tT-1\nthe\tO\ncause\tO\nof\tO\nthis\tO\nlesion\tO\nboth\tO\nin\tO\nallografts\tO\nand\tO\nnative\tO\nkidneys\tO\n.\tO\n\nWe\tO\nsuggest\tO\nthat\tO\nrepeated\tT-0\nendothelial\tO\ninjury\tO\n,\tO\nincluding\tO\nimmunologic\tB-Disease\ninjury\tI-Disease\n,\tO\nmay\tO\nbe\tO\nthe\tO\ncause\tT-1\nof\tO\nthis\tO\nlesion\tO\nboth\tO\nin\tO\nallografts\tO\nand\tO\nnative\tO\nkidneys\tO\n.\tO\n\nCaffeine\tB-Chemical\n-\tO\ninduced\tT-0\ncardiac\tO\narrhythmia\tO\n:\tO\nan\tO\nunrecognised\tO\ndanger\tO\nof\tO\nhealthfood\tO\nproducts\tO\n.\tO\n\nCaffeine\tO\n-\tO\ninduced\tT-0\ncardiac\tB-Disease\narrhythmia\tI-Disease\n:\tO\nan\tO\nunrecognised\tO\ndanger\tO\nof\tO\nhealthfood\tO\nproducts\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tT-1\npre\tT-1\n-\tT-1\nexisting\tT-1\nmitral\tB-Disease\nvalve\tI-Disease\nprolapse\tI-Disease\nwho\tO\ndeveloped\tO\nintractable\tO\nventricular\tO\nfibrillation\tO\nafter\tO\nconsuming\tO\na\tO\n\"\tO\nnatural\tO\nenergy\tO\n\"\tO\nguarana\tO\nhealth\tO\ndrink\tO\ncontaining\tO\na\tO\nhigh\tO\nconcentration\tO\nof\tO\ncaffeine\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\npre\tO\n-\tO\nexisting\tO\nmitral\tO\nvalve\tO\nprolapse\tO\nwho\tO\ndeveloped\tO\nintractable\tT-0\nventricular\tB-Disease\nfibrillation\tI-Disease\nafter\tT-1\nconsuming\tT-1\na\tO\n\"\tO\nnatural\tO\nenergy\tO\n\"\tO\nguarana\tO\nhealth\tO\ndrink\tO\ncontaining\tO\na\tO\nhigh\tO\nconcentration\tO\nof\tO\ncaffeine\tO\n.\tO\n\nWe\tO\ndescribe\tO\na\tO\n25\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nwoman\tO\nwith\tO\npre\tO\n-\tO\nexisting\tO\nmitral\tO\nvalve\tO\nprolapse\tO\nwho\tO\ndeveloped\tT-0\nintractable\tO\nventricular\tO\nfibrillation\tO\nafter\tO\nconsuming\tT-1\na\tO\n\"\tO\nnatural\tO\nenergy\tO\n\"\tO\nguarana\tO\nhealth\tO\ndrink\tO\ncontaining\tO\na\tO\nhigh\tO\nconcentration\tT-2\nof\tT-2\ncaffeine\tB-Chemical\n.\tO\n\nConformationally\tT-1\nrestricted\tT-2\nanalogs\tT-2\nof\tT-0\nBD1008\tB-Chemical\nand\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tO\ntargeting\tO\nsigma1\tO\nreceptors\tO\nproduce\tT-3\nanti\tO\n-\tO\ncocaine\tO\neffects\tO\nin\tO\nmice\tO\n.\tO\n\nConformationally\tO\nrestricted\tT-0\nanalogs\tO\nof\tO\nBD1008\tO\nand\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tB-Chemical\ntargeting\tT-2\nsigma1\tO\nreceptors\tO\nproduce\tT-1\nanti\tO\n-\tO\ncocaine\tO\neffects\tO\nin\tO\nmice\tO\n.\tO\n\nConformationally\tO\nrestricted\tO\nanalogs\tO\nof\tO\nBD1008\tO\nand\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tO\ntargeting\tO\nsigma1\tO\nreceptors\tO\nproduce\tT-0\nanti\tT-1\n-\tT-1\ncocaine\tB-Chemical\neffects\tT-2\nin\tO\nmice\tO\n.\tO\n\nCocaine\tB-Chemical\n'\tO\ns\tO\nability\tT-0\nto\tT-0\ninteract\tO\nwith\tO\nsigma\tO\nreceptors\tO\nsuggests\tT-1\nthat\tO\nthese\tO\nproteins\tO\nmediate\tO\nsome\tO\nof\tO\nits\tO\nbehavioral\tO\neffects\tO\n.\tO\n\nTherefore\tO\n,\tO\nthree\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nligands\tO\nwith\tO\nantagonist\tO\nactivity\tO\nwere\tO\nevaluated\tO\nin\tO\nSwiss\tO\nWebster\tO\nmice\tO\n:\tO\nBD1018\tB-Chemical\n(\tT-0\n3S\tT-0\n-\tT-0\n1\tT-0\n-\tT-0\n[\tT-0\n2\tT-0\n-\tT-0\n(\tT-0\n3\tT-0\n,\tT-0\n4\tT-0\n-\tT-0\ndichlorophenyl\tT-0\n)\tT-0\nethyl\tO\n]\tO\n-\tO\n1\tO\n,\tO\n4\tO\n-\tO\ndiazabicyclo\tO\n[\tO\n4\tO\n.\tO\n3\tO\n.\tO\n0\tO\n]\tO\nnonane\tO\n)\tO\n,\tO\nBD1063\tO\n(\tO\n1\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n4\tO\n-\tO\nmethylpiperazine\tO\n)\tO\n,\tO\nand\tO\nLR132\tO\n(\tO\n1R\tO\n,\tO\n2S\tO\n-\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncis\tO\n-\tO\nN\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n2\tO\n-\tO\n(\tO\n1\tO\n-\tO\npyrrolidinyl\tO\n)\tO\ncyclohexylamine\tO\n)\tO\n.\tO\n\nTherefore\tO\n,\tO\nthree\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nligands\tO\nwith\tO\nantagonist\tO\nactivity\tO\nwere\tO\nevaluated\tT-0\nin\tO\nSwiss\tO\nWebster\tO\nmice\tO\n:\tO\nBD1018\tO\n(\tO\n3S\tB-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichlorophenyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndiazabicyclo\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n.\tI-Chemical\n3\tI-Chemical\n.\tI-Chemical\n0\tI-Chemical\n]\tI-Chemical\nnonane\tI-Chemical\n)\tO\n,\tO\nBD1063\tO\n(\tO\n1\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n4\tO\n-\tO\nmethylpiperazine\tO\n)\tO\n,\tO\nand\tO\nLR132\tO\n(\tO\n1R\tO\n,\tO\n2S\tO\n-\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncis\tO\n-\tO\nN\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n2\tO\n-\tO\n(\tO\n1\tO\n-\tO\npyrrolidinyl\tO\n)\tO\ncyclohexylamine\tO\n)\tO\n.\tO\n\nTherefore\tO\n,\tO\nthree\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nligands\tO\nwith\tO\nantagonist\tO\nactivity\tO\nwere\tO\nevaluated\tO\nin\tO\nSwiss\tO\nWebster\tO\nmice\tO\n:\tO\nBD1018\tO\n(\tO\n3S\tT-0\n-\tT-0\n1\tT-0\n-\tT-0\n[\tT-0\n2\tT-0\n-\tT-0\n(\tT-0\n3\tT-0\n,\tT-0\n4\tT-0\n-\tT-0\ndichlorophenyl\tT-0\n)\tT-0\nethyl\tT-0\n]\tO\n-\tO\n1\tO\n,\tO\n4\tO\n-\tO\ndiazabicyclo\tO\n[\tO\n4\tO\n.\tO\n3\tO\n.\tO\n0\tO\n]\tO\nnonane\tO\n)\tO\n,\tO\nBD1063\tB-Chemical\n(\tO\n1\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n4\tO\n-\tO\nmethylpiperazine\tO\n)\tO\n,\tO\nand\tO\nLR132\tO\n(\tO\n1R\tO\n,\tO\n2S\tO\n-\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncis\tO\n-\tO\nN\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n2\tO\n-\tO\n(\tO\n1\tO\n-\tO\npyrrolidinyl\tO\n)\tO\ncyclohexylamine\tO\n)\tO\n.\tO\n\nTherefore\tO\n,\tO\nthree\tO\nnovel\tO\nsigma\tT-2\nreceptor\tT-2\nligands\tO\nwith\tO\nantagonist\tO\nactivity\tO\nwere\tO\nevaluated\tT-1\nin\tO\nSwiss\tO\nWebster\tO\nmice\tO\n:\tO\nBD1018\tO\n(\tO\n3S\tT-0\n-\tT-0\n1\tT-0\n-\tT-0\n[\tT-0\n2\tT-0\n-\tT-0\n(\tT-0\n3\tT-0\n,\tT-0\n4\tT-0\n-\tT-0\ndichlorophenyl\tT-0\n)\tT-0\nethyl\tT-0\n]\tO\n-\tO\n1\tO\n,\tO\n4\tO\n-\tO\ndiazabicyclo\tO\n[\tO\n4\tO\n.\tO\n3\tO\n.\tO\n0\tO\n]\tO\nnonane\tO\n)\tO\n,\tO\nBD1063\tO\n(\tO\n1\tB-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichlorophenyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\nmethylpiperazine\tI-Chemical\n)\tO\n,\tO\nand\tO\nLR132\tO\n(\tO\n1R\tO\n,\tO\n2S\tO\n-\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncis\tO\n-\tO\nN\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n2\tO\n-\tO\n(\tO\n1\tO\n-\tO\npyrrolidinyl\tO\n)\tO\ncyclohexylamine\tO\n)\tO\n.\tO\n\nTherefore\tO\n,\tO\nthree\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nligands\tO\nwith\tO\nantagonist\tO\nactivity\tO\nwere\tO\nevaluated\tT-0\nin\tT-0\nSwiss\tO\nWebster\tO\nmice\tO\n:\tO\nBD1018\tO\n(\tO\n3S\tO\n-\tO\n1\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n1\tO\n,\tO\n4\tO\n-\tO\ndiazabicyclo\tO\n[\tO\n4\tO\n.\tO\n3\tO\n.\tO\n0\tO\n]\tO\nnonane\tO\n)\tO\n,\tO\nBD1063\tO\n(\tO\n1\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n4\tO\n-\tO\nmethylpiperazine\tO\n)\tO\n,\tO\nand\tO\nLR132\tB-Chemical\n(\tO\n1R\tO\n,\tO\n2S\tO\n-\tO\n(\tO\n+\tO\n)\tO\n-\tO\ncis\tO\n-\tO\nN\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n2\tO\n-\tO\n(\tO\n1\tO\n-\tO\npyrrolidinyl\tO\n)\tO\ncyclohexylamine\tO\n)\tO\n.\tO\n\nThe\tO\nthree\tO\ncompounds\tO\nvary\tO\nin\tO\ntheir\tO\naffinities\tO\nfor\tO\nsigma2\tO\nreceptors\tO\nand\tO\nexhibit\tT-1\nnegligible\tO\naffinities\tO\nfor\tO\ndopamine\tB-Chemical\n,\tO\nopioid\tO\n,\tO\nGABA\tT-0\n(\tO\nA\tO\n)\tO\nand\tO\nNMDA\tO\nreceptors\tO\n.\tO\n\nThe\tO\nthree\tO\ncompounds\tO\nvary\tO\nin\tO\ntheir\tO\naffinities\tO\nfor\tO\nsigma2\tO\nreceptors\tO\nand\tO\nexhibit\tO\nnegligible\tO\naffinities\tO\nfor\tO\ndopamine\tO\n,\tO\nopioid\tT-0\n,\tO\nGABA\tB-Chemical\n(\tT-2\nA\tT-2\n)\tT-2\nand\tO\nNMDA\tO\nreceptors\tO\n.\tO\n\nThe\tO\nthree\tO\ncompounds\tO\nvary\tO\nin\tO\ntheir\tO\naffinities\tO\nfor\tO\nsigma2\tO\nreceptors\tO\nand\tO\nexhibit\tT-0\nnegligible\tO\naffinities\tO\nfor\tO\ndopamine\tT-3\n,\tT-3\nopioid\tT-3\n,\tT-3\nGABA\tT-3\n(\tT-3\nA\tT-3\n)\tT-3\nand\tO\nNMDA\tB-Chemical\nreceptors\tT-4\n.\tO\n\nIn\tO\nbehavioral\tO\nstudies\tO\n,\tO\npre\tO\n-\tO\ntreatment\tO\nof\tO\nmice\tO\nwith\tT-2\nBD1018\tB-Chemical\n,\tO\nBD1063\tO\n,\tO\nor\tO\nLR132\tO\nsignificantly\tT-0\nattenuated\tT-0\ncocaine\tO\n-\tO\ninduced\tT-1\nconvulsions\tO\nand\tO\nlethality\tO\n.\tO\n\nIn\tO\nbehavioral\tT-1\nstudies\tT-1\n,\tO\npre\tO\n-\tO\ntreatment\tT-2\nof\tO\nmice\tO\nwith\tO\nBD1018\tO\n,\tO\nBD1063\tB-Chemical\n,\tO\nor\tO\nLR132\tO\nsignificantly\tO\nattenuated\tO\ncocaine\tO\n-\tO\ninduced\tT-3\nconvulsions\tO\nand\tO\nlethality\tO\n.\tO\n\nIn\tO\nbehavioral\tO\nstudies\tO\n,\tO\npre\tT-1\n-\tT-1\ntreatment\tT-1\nof\tT-1\nmice\tT-1\nwith\tO\nBD1018\tO\n,\tO\nBD1063\tT-0\n,\tO\nor\tO\nLR132\tB-Chemical\nsignificantly\tT-2\nattenuated\tT-2\ncocaine\tT-3\n-\tT-3\ninduced\tT-3\nconvulsions\tT-3\nand\tT-3\nlethality\tT-3\n.\tO\n\nIn\tO\nbehavioral\tO\nstudies\tO\n,\tO\npre\tO\n-\tO\ntreatment\tO\nof\tO\nmice\tO\nwith\tO\nBD1018\tO\n,\tO\nBD1063\tO\n,\tO\nor\tO\nLR132\tO\nsignificantly\tT-1\nattenuated\tT-1\ncocaine\tB-Chemical\n-\tO\ninduced\tT-2\nconvulsions\tT-2\nand\tO\nlethality\tT-3\n.\tO\n\nIn\tO\nbehavioral\tO\nstudies\tO\n,\tO\npre\tO\n-\tO\ntreatment\tO\nof\tO\nmice\tO\nwith\tO\nBD1018\tO\n,\tO\nBD1063\tO\n,\tO\nor\tO\nLR132\tO\nsignificantly\tO\nattenuated\tT-1\ncocaine\tO\n-\tO\ninduced\tT-2\nconvulsions\tB-Disease\nand\tO\nlethality\tT-0\n.\tO\n\nMoreover\tO\n,\tO\npost\tO\n-\tO\ntreatment\tO\nwith\tO\nLR132\tB-Chemical\nprevented\tT-2\ncocaine\tT-0\n-\tO\ninduced\tT-3\nlethality\tO\nin\tO\na\tO\nsignificant\tO\nproportion\tO\nof\tO\nanimals\tO\n.\tO\n\nMoreover\tO\n,\tO\npost\tO\n-\tO\ntreatment\tT-2\nwith\tO\nLR132\tO\nprevented\tT-1\ncocaine\tB-Chemical\n-\tO\ninduced\tT-3\nlethality\tO\nin\tO\na\tO\nsignificant\tO\nproportion\tO\nof\tO\nanimals\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\nthe\tO\nprotection\tO\nprovided\tT-1\nby\tT-1\nthe\tO\nputative\tO\nantagonists\tO\n,\tO\nthe\tO\nwell\tO\n-\tO\ncharacterized\tO\nsigma\tO\nreceptor\tO\nagonist\tO\ndi\tB-Chemical\n-\tI-Chemical\no\tI-Chemical\n-\tI-Chemical\ntolylguanidine\tI-Chemical\n(\tO\nDTG\tO\n)\tO\nand\tO\nthe\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nagonist\tO\nBD1031\tO\n(\tO\n3R\tO\n-\tO\n1\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n1\tO\n,\tO\n4\tO\n-\tO\ndiazabicyclo\tO\n[\tO\n4\tO\n.\tO\n3\tO\n.\tO\n0\tO\n]\tO\nnonane\tO\n)\tO\neach\tO\nworsened\tT-2\nthe\tO\nbehavioral\tO\ntoxicity\tO\nof\tO\ncocaine\tO\n.\tO\n\nIn\tO\ncontrast\tT-1\nto\tO\nthe\tO\nprotection\tO\nprovided\tO\nby\tO\nthe\tO\nputative\tO\nantagonists\tO\n,\tO\nthe\tO\nwell\tO\n-\tO\ncharacterized\tO\nsigma\tO\nreceptor\tT-2\nagonist\tO\ndi\tO\n-\tO\no\tO\n-\tO\ntolylguanidine\tO\n(\tO\nDTG\tB-Chemical\n)\tO\nand\tO\nthe\tO\nnovel\tT-0\nsigma\tT-0\nreceptor\tT-0\nagonist\tT-0\nBD1031\tT-0\n(\tO\n3R\tO\n-\tO\n1\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n1\tO\n,\tO\n4\tO\n-\tO\ndiazabicyclo\tO\n[\tO\n4\tO\n.\tO\n3\tO\n.\tO\n0\tO\n]\tO\nnonane\tO\n)\tO\neach\tO\nworsened\tO\nthe\tO\nbehavioral\tO\ntoxicity\tT-3\nof\tO\ncocaine\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\nthe\tO\nprotection\tT-2\nprovided\tT-2\nby\tT-2\nthe\tO\nputative\tO\nantagonists\tO\n,\tO\nthe\tO\nwell\tO\n-\tO\ncharacterized\tO\nsigma\tO\nreceptor\tO\nagonist\tO\ndi\tO\n-\tO\no\tO\n-\tO\ntolylguanidine\tO\n(\tO\nDTG\tO\n)\tO\nand\tO\nthe\tO\nnovel\tT-5\nsigma\tT-5\nreceptor\tT-5\nagonist\tT-5\nBD1031\tB-Chemical\n(\tO\n3R\tT-0\n-\tT-0\n1\tT-0\n-\tT-0\n[\tT-0\n2\tT-0\n-\tT-0\n(\tT-0\n3\tT-0\n,\tT-0\n4\tT-0\n-\tT-0\ndichlorophenyl\tT-0\n)\tO\nethyl\tT-1\n]\tO\n-\tO\n1\tO\n,\tO\n4\tO\n-\tO\ndiazabicyclo\tO\n[\tO\n4\tO\n.\tO\n3\tO\n.\tO\n0\tO\n]\tO\nnonane\tO\n)\tO\neach\tT-6\nworsened\tT-6\nthe\tO\nbehavioral\tT-4\ntoxicity\tT-4\nof\tO\ncocaine\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\nthe\tO\nprotection\tO\nprovided\tT-1\nby\tT-1\nthe\tO\nputative\tO\nantagonists\tO\n,\tO\nthe\tO\nwell\tO\n-\tO\ncharacterized\tO\nsigma\tO\nreceptor\tO\nagonist\tO\ndi\tT-3\n-\tT-3\no\tT-3\n-\tT-3\ntolylguanidine\tT-3\n(\tO\nDTG\tO\n)\tO\nand\tO\nthe\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nagonist\tO\nBD1031\tT-4\n(\tO\n3R\tB-Chemical\n-\tI-Chemical\n1\tI-Chemical\n-\tI-Chemical\n[\tI-Chemical\n2\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\n3\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndichlorophenyl\tI-Chemical\n)\tI-Chemical\nethyl\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\n1\tI-Chemical\n,\tI-Chemical\n4\tI-Chemical\n-\tI-Chemical\ndiazabicyclo\tI-Chemical\n[\tI-Chemical\n4\tI-Chemical\n.\tI-Chemical\n3\tI-Chemical\n.\tI-Chemical\n0\tI-Chemical\n]\tI-Chemical\nnonane\tI-Chemical\n)\tO\neach\tO\nworsened\tT-2\nthe\tO\nbehavioral\tT-0\ntoxicity\tT-0\nof\tO\ncocaine\tO\n.\tO\n\nIn\tO\ncontrast\tO\nto\tO\nthe\tO\nprotection\tO\nprovided\tO\nby\tO\nthe\tO\nputative\tO\nantagonists\tO\n,\tO\nthe\tO\nwell\tO\n-\tO\ncharacterized\tO\nsigma\tO\nreceptor\tO\nagonist\tO\ndi\tO\n-\tO\no\tO\n-\tO\ntolylguanidine\tO\n(\tO\nDTG\tO\n)\tO\nand\tO\nthe\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nagonist\tO\nBD1031\tO\n(\tO\n3R\tT-0\n-\tT-0\n1\tT-0\n-\tT-0\n[\tT-0\n2\tT-0\n-\tT-0\n(\tT-0\n3\tT-0\n,\tT-0\n4\tT-0\n-\tT-0\ndichlorophenyl\tT-0\n)\tT-0\nethyl\tT-0\n]\tO\n-\tO\n1\tO\n,\tO\n4\tO\n-\tO\ndiazabicyclo\tO\n[\tO\n4\tO\n.\tO\n3\tO\n.\tO\n0\tO\n]\tO\nnonane\tO\n)\tO\neach\tO\nworsened\tT-2\nthe\tO\nbehavioral\tO\ntoxicity\tB-Disease\nof\tT-3\ncocaine\tT-3\n.\tT-2\n\nIn\tO\ncontrast\tO\nto\tO\nthe\tO\nprotection\tO\nprovided\tO\nby\tO\nthe\tO\nputative\tO\nantagonists\tO\n,\tO\nthe\tO\nwell\tO\n-\tO\ncharacterized\tO\nsigma\tO\nreceptor\tO\nagonist\tO\ndi\tO\n-\tO\no\tO\n-\tO\ntolylguanidine\tO\n(\tT-1\nDTG\tT-1\n)\tT-1\nand\tO\nthe\tO\nnovel\tO\nsigma\tO\nreceptor\tO\nagonist\tO\nBD1031\tO\n(\tO\n3R\tO\n-\tO\n1\tO\n-\tO\n[\tO\n2\tO\n-\tO\n(\tO\n3\tO\n,\tO\n4\tO\n-\tO\ndichlorophenyl\tO\n)\tO\nethyl\tO\n]\tO\n-\tO\n1\tO\n,\tO\n4\tO\n-\tO\ndiazabicyclo\tO\n[\tO\n4\tO\n.\tO\n3\tO\n.\tO\n0\tO\n]\tO\nnonane\tO\n)\tO\neach\tO\nworsened\tT-0\nthe\tO\nbehavioral\tO\ntoxicity\tT-3\nof\tT-3\ncocaine\tB-Chemical\n.\tO\n\nAt\tO\ndoses\tO\nwhere\tO\nalone\tO\n,\tO\nthey\tT-2\nproduced\tT-2\nno\tT-3\nsignificant\tT-3\neffects\tT-3\non\tO\nlocomotion\tO\n,\tO\nBD1018\tB-Chemical\n,\tO\nBD1063\tT-0\nand\tO\nLR132\tT-1\nsignificantly\tO\nattenuated\tO\nthe\tO\nlocomotor\tO\nstimulatory\tO\neffects\tO\nof\tO\ncocaine\tO\n.\tO\n\nAt\tO\ndoses\tO\nwhere\tO\nalone\tO\n,\tO\nthey\tO\nproduced\tO\nno\tT-1\nsignificant\tT-1\neffects\tT-1\non\tO\nlocomotion\tO\n,\tO\nBD1018\tO\n,\tO\nBD1063\tB-Chemical\nand\tO\nLR132\tO\nsignificantly\tT-0\nattenuated\tT-0\nthe\tO\nlocomotor\tO\nstimulatory\tO\neffects\tO\nof\tO\ncocaine\tO\n.\tO\n\nAt\tO\ndoses\tT-3\nwhere\tO\nalone\tO\n,\tO\nthey\tO\nproduced\tO\nno\tO\nsignificant\tT-4\neffects\tT-4\non\tO\nlocomotion\tO\n,\tO\nBD1018\tT-0\n,\tO\nBD1063\tT-1\nand\tO\nLR132\tB-Chemical\nsignificantly\tT-6\nattenuated\tT-6\nthe\tO\nlocomotor\tO\nstimulatory\tT-5\neffects\tT-5\nof\tO\ncocaine\tT-2\n.\tO\n\nAt\tO\ndoses\tO\nwhere\tO\nalone\tO\n,\tO\nthey\tO\nproduced\tO\nno\tO\nsignificant\tO\neffects\tO\non\tO\nlocomotion\tO\n,\tO\nBD1018\tT-0\n,\tO\nBD1063\tT-1\nand\tO\nLR132\tT-2\nsignificantly\tO\nattenuated\tO\nthe\tO\nlocomotor\tO\nstimulatory\tO\neffects\tT-3\nof\tT-3\ncocaine\tB-Chemical\n.\tO\n\nTo\tO\nfurther\tO\nvalidate\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\nanti\tO\n-\tO\ncocaine\tB-Chemical\neffects\tO\nof\tO\nthe\tO\nnovel\tO\nligands\tO\ninvolved\tO\nantagonism\tO\nof\tO\nsigma\tO\nreceptors\tO\n,\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tO\nagainst\tO\nsigma1\tO\nreceptors\tO\nwas\tO\nalso\tO\nshown\tO\nto\tO\nsignificantly\tO\nattenuate\tO\nthe\tO\nconvulsive\tT-0\nand\tO\nlocomotor\tO\nstimulatory\tO\neffects\tO\nof\tO\ncocaine\tO\n.\tO\n\nTo\tO\nfurther\tO\nvalidate\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\nanti\tO\n-\tO\ncocaine\tO\neffects\tO\nof\tO\nthe\tO\nnovel\tO\nligands\tO\ninvolved\tO\nantagonism\tO\nof\tO\nsigma\tO\nreceptors\tO\n,\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tB-Chemical\nagainst\tO\nsigma1\tT-1\nreceptors\tO\nwas\tT-0\nalso\tT-0\nshown\tT-0\nto\tO\nsignificantly\tO\nattenuate\tO\nthe\tO\nconvulsive\tO\nand\tO\nlocomotor\tO\nstimulatory\tO\neffects\tO\nof\tO\ncocaine\tO\n.\tO\n\nTo\tO\nfurther\tO\nvalidate\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\nanti\tO\n-\tO\ncocaine\tO\neffects\tO\nof\tO\nthe\tO\nnovel\tO\nligands\tO\ninvolved\tO\nantagonism\tO\nof\tO\nsigma\tO\nreceptors\tO\n,\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tO\nagainst\tO\nsigma1\tO\nreceptors\tO\nwas\tO\nalso\tO\nshown\tO\nto\tO\nsignificantly\tO\nattenuate\tT-2\nthe\tT-2\nconvulsive\tB-Disease\nand\tO\nlocomotor\tT-0\nstimulatory\tT-0\neffects\tT-0\nof\tO\ncocaine\tO\n.\tO\n\nTo\tO\nfurther\tO\nvalidate\tO\nthe\tO\nhypothesis\tO\nthat\tO\nthe\tO\nanti\tO\n-\tO\ncocaine\tO\neffects\tO\nof\tO\nthe\tO\nnovel\tO\nligands\tO\ninvolved\tO\nantagonism\tO\nof\tO\nsigma\tO\nreceptors\tO\n,\tO\nan\tO\nantisense\tO\noligodeoxynucleotide\tT-0\nagainst\tO\nsigma1\tO\nreceptors\tO\nwas\tO\nalso\tO\nshown\tO\nto\tO\nsignificantly\tO\nattenuate\tO\nthe\tO\nconvulsive\tO\nand\tO\nlocomotor\tO\nstimulatory\tO\neffects\tT-1\nof\tT-1\ncocaine\tB-Chemical\n.\tO\n\nTogether\tO\n,\tO\nthe\tO\ndata\tO\nsuggests\tO\nthat\tO\nfunctional\tO\nantagonism\tO\nof\tO\nsigma\tO\nreceptors\tT-0\nis\tO\ncapable\tO\nof\tO\nattenuating\tT-2\na\tT-2\nnumber\tT-2\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tT-3\nbehaviors\tT-3\n.\tO\n\nRanitidine\tB-Chemical\n-\tO\ninduced\tT-2\nacute\tT-2\ninterstitial\tT-2\nnephritis\tT-2\nin\tO\na\tO\ncadaveric\tO\nrenal\tO\nallograft\tO\n.\tO\n\nRanitidine\tT-2\n-\tT-2\ninduced\tT-2\nacute\tT-2\ninterstitial\tB-Disease\nnephritis\tI-Disease\nin\tO\na\tO\ncadaveric\tT-3\nrenal\tT-3\nallograft\tT-3\n.\tO\n\nRanitidine\tB-Chemical\nfrequently\tO\nis\tT-0\nused\tT-0\nfor\tO\npreventing\tO\npeptic\tT-1\nulceration\tT-1\nafter\tO\nrenal\tO\ntransplantation\tO\n.\tO\n\nThis\tO\ndrug\tT-0\noccasionally\tO\nhas\tO\nbeen\tO\nassociated\tO\nwith\tO\nacute\tT-1\ninterstitial\tB-Disease\nnephritis\tI-Disease\nin\tO\nnative\tO\nkidneys\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\nranitidine\tB-Chemical\n-\tO\ninduced\tT-2\nacute\tT-2\ninterstitial\tT-2\nnephritis\tT-2\nin\tO\na\tO\nrecipient\tO\nof\tO\na\tO\ncadaveric\tO\nrenal\tO\nallograft\tO\npresenting\tO\nwith\tO\nacute\tO\nallograft\tO\ndysfunction\tO\nwithin\tO\n48\tO\nhours\tO\nof\tO\nexposure\tO\nto\tO\nthe\tO\ndrug\tT-1\n.\tO\n\nWe\tO\nreport\tT-0\na\tT-0\ncase\tT-0\nof\tO\nranitidine\tO\n-\tO\ninduced\tT-2\nacute\tO\ninterstitial\tB-Disease\nnephritis\tI-Disease\nin\tT-3\na\tT-3\nrecipient\tT-3\nof\tO\na\tO\ncadaveric\tO\nrenal\tO\nallograft\tO\npresenting\tO\nwith\tO\nacute\tO\nallograft\tO\ndysfunction\tO\nwithin\tO\n48\tO\nhours\tO\nof\tO\nexposure\tO\nto\tO\nthe\tO\ndrug\tO\n.\tO\n\nLiver\tB-Disease\ndisease\tI-Disease\ncaused\tT-1\nby\tT-1\npropylthiouracil\tT-0\n.\tO\n\nLiver\tT-0\ndisease\tO\ncaused\tT-1\nby\tT-1\npropylthiouracil\tB-Chemical\n.\tO\n\nThis\tO\nreport\tO\npresents\tO\nthe\tO\nclinical\tO\n,\tO\nlaboratory\tO\n,\tO\nand\tO\nlight\tO\nand\tO\nelectron\tO\nmicroscopic\tO\nobservations\tO\non\tT-2\na\tT-2\npatient\tT-2\nwith\tT-2\nchronic\tB-Disease\nactive\tI-Disease\n(\tI-Disease\naggressive\tI-Disease\n)\tI-Disease\nhepatitis\tI-Disease\ncaused\tT-3\nby\tT-3\nthe\tT-3\nadministration\tO\nof\tO\npropylthiouracil\tT-0\n.\tO\n\nThis\tO\nreport\tO\npresents\tO\nthe\tO\nclinical\tO\n,\tO\nlaboratory\tO\n,\tO\nand\tO\nlight\tO\nand\tO\nelectron\tO\nmicroscopic\tO\nobservations\tO\non\tO\na\tO\npatient\tO\nwith\tO\nchronic\tO\nactive\tO\n(\tT-0\naggressive\tT-0\n)\tT-0\nhepatitis\tT-3\ncaused\tT-2\nby\tT-2\nthe\tO\nadministration\tT-1\nof\tT-1\npropylthiouracil\tB-Chemical\n.\tO\n\nThis\tO\nis\tO\nan\tO\naddition\tO\nto\tO\nthe\tO\nlist\tO\nof\tO\ndrugs\tO\nthat\tO\nmust\tO\nbe\tO\nconsidered\tO\nin\tO\nthe\tO\nevaluation\tT-0\nof\tT-0\nchronic\tT-1\nliver\tB-Disease\ndisease\tI-Disease\n.\tO\n\nWithdrawal\tB-Disease\n-\tI-Disease\nemergent\tI-Disease\nrabbit\tI-Disease\nsyndrome\tI-Disease\nduring\tT-1\ndose\tO\nreduction\tO\nof\tO\nrisperidone\tT-0\n.\tO\n\nWithdrawal\tO\n-\tO\nemergent\tO\nrabbit\tO\nsyndrome\tT-1\nduring\tT-0\ndose\tT-2\nreduction\tT-2\nof\tO\nrisperidone\tB-Chemical\n.\tO\n\nRabbit\tB-Disease\nsyndrome\tI-Disease\n(\tO\nRS\tO\n)\tO\nis\tO\na\tO\nrare\tT-2\nextrapyramidal\tT-2\nside\tT-2\neffect\tT-2\ncaused\tT-1\nby\tO\nprolonged\tT-3\nneuroleptic\tT-3\nmedication\tT-3\n.\tO\n\nRabbit\tT-1\nsyndrome\tT-1\n(\tO\nRS\tB-Disease\n)\tO\nis\tT-0\na\tT-0\nrare\tT-0\nextrapyramidal\tT-0\nside\tO\neffect\tO\ncaused\tO\nby\tO\nprolonged\tO\nneuroleptic\tO\nmedication\tO\n.\tO\n\nHere\tO\nwe\tO\npresent\tO\na\tO\ncase\tT-2\nof\tT-2\nwithdrawal\tB-Disease\n-\tI-Disease\nemergent\tI-Disease\nRS\tI-Disease\n,\tO\nwhich\tT-1\nis\tT-1\nthe\tT-1\nfirst\tT-1\nof\tT-1\nits\tT-1\nkind\tT-1\nto\tT-1\nbe\tT-1\nreported\tT-1\n.\tO\n\nThe\tO\npatient\tO\ndeveloped\tO\nRS\tB-Disease\nduring\tT-0\ndose\tT-0\nreduction\tT-0\nof\tT-0\nrisperidone\tT-0\n.\tO\n\nThe\tO\npatient\tO\ndeveloped\tO\nRS\tO\nduring\tO\ndose\tT-0\nreduction\tT-0\nof\tT-0\nrisperidone\tB-Chemical\n.\tO\n\nThe\tO\nsymptom\tO\nwas\tT-0\ntreated\tT-1\nsuccessfully\tO\nwith\tO\ntrihexyphenidyl\tB-Chemical\nanticholinergic\tO\ntherapy\tO\n.\tO\n\nThe\tO\nunderlying\tO\nmechanism\tT-1\nof\tT-1\nwithdrawal\tB-Disease\n-\tI-Disease\nemergent\tI-Disease\nRS\tI-Disease\nin\tO\nthe\tO\npresent\tO\ncase\tO\nmay\tO\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nthe\tO\npharmacological\tO\nprofile\tO\nof\tO\nrisperidone\tO\n,\tO\na\tO\nserotonin\tO\n-\tO\ndopamine\tO\nantagonist\tO\n,\tO\nsuggesting\tO\nthe\tO\npathophysiologic\tO\ninfluence\tT-2\nof\tT-2\nthe\tO\nserotonin\tO\nsystem\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nRS\tO\n.\tO\n\nThe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nwithdrawal\tO\n-\tO\nemergent\tO\nRS\tO\nin\tO\nthe\tO\npresent\tO\ncase\tO\nmay\tO\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nthe\tO\npharmacological\tO\nprofile\tO\nof\tO\nrisperidone\tB-Chemical\n,\tO\na\tT-0\nserotonin\tT-0\n-\tO\ndopamine\tO\nantagonist\tO\n,\tO\nsuggesting\tO\nthe\tO\npathophysiologic\tO\ninfluence\tO\nof\tO\nthe\tO\nserotonin\tO\nsystem\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nRS\tO\n.\tO\n\nThe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nwithdrawal\tO\n-\tO\nemergent\tO\nRS\tO\nin\tO\nthe\tO\npresent\tO\ncase\tO\nmay\tO\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nthe\tO\npharmacological\tO\nprofile\tO\nof\tO\nrisperidone\tO\n,\tO\na\tO\nserotonin\tO\n-\tO\ndopamine\tB-Chemical\nantagonist\tT-1\n,\tO\nsuggesting\tT-0\nthe\tT-0\npathophysiologic\tO\ninfluence\tO\nof\tO\nthe\tO\nserotonin\tO\nsystem\tO\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nRS\tO\n.\tO\n\nThe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nwithdrawal\tO\n-\tO\nemergent\tO\nRS\tO\nin\tO\nthe\tO\npresent\tO\ncase\tO\nmay\tO\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nthe\tO\npharmacological\tO\nprofile\tO\nof\tO\nrisperidone\tO\n,\tO\na\tO\nserotonin\tO\n-\tO\ndopamine\tO\nantagonist\tO\n,\tO\nsuggesting\tO\nthe\tO\npathophysiologic\tT-0\ninfluence\tT-2\nof\tT-2\nthe\tO\nserotonin\tB-Chemical\nsystem\tT-1\nin\tO\nthe\tO\ndevelopment\tO\nof\tO\nRS\tO\n.\tO\n\nThe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nwithdrawal\tO\n-\tO\nemergent\tO\nRS\tO\nin\tO\nthe\tO\npresent\tO\ncase\tO\nmay\tO\nhave\tO\nbeen\tO\nrelated\tO\nto\tO\nthe\tO\npharmacological\tO\nprofile\tO\nof\tO\nrisperidone\tO\n,\tO\na\tO\nserotonin\tO\n-\tO\ndopamine\tO\nantagonist\tO\n,\tO\nsuggesting\tO\nthe\tO\npathophysiologic\tO\ninfluence\tO\nof\tO\nthe\tO\nserotonin\tO\nsystem\tO\nin\tO\nthe\tO\ndevelopment\tT-0\nof\tT-0\nRS\tB-Disease\n.\tO\n\nPharmacokinetic\tO\n/\tO\npharmacodynamic\tO\nassessment\tO\nof\tO\nthe\tO\neffects\tT-1\nof\tT-1\nE4031\tB-Chemical\n,\tO\ncisapride\tO\n,\tO\nterfenadine\tO\nand\tO\nterodiline\tO\non\tO\nmonophasic\tO\naction\tO\npotential\tT-0\nduration\tT-0\nin\tT-0\ndog\tT-0\n.\tO\n\nPharmacokinetic\tO\n/\tO\npharmacodynamic\tO\nassessment\tO\nof\tO\nthe\tO\neffects\tT-0\nof\tO\nE4031\tO\n,\tO\ncisapride\tB-Chemical\n,\tO\nterfenadine\tO\nand\tO\nterodiline\tO\non\tO\nmonophasic\tT-2\naction\tT-2\npotential\tT-2\nduration\tT-2\nin\tT-2\ndog\tT-2\n.\tT-2\n\nPharmacokinetic\tO\n/\tO\npharmacodynamic\tO\nassessment\tT-0\nof\tT-0\nthe\tT-0\neffects\tT-1\nof\tT-1\nE4031\tO\n,\tO\ncisapride\tO\n,\tO\nterfenadine\tB-Chemical\nand\tO\nterodiline\tO\non\tO\nmonophasic\tO\naction\tO\npotential\tO\nduration\tO\nin\tO\ndog\tO\n.\tO\n\nPharmacokinetic\tO\n/\tO\npharmacodynamic\tO\nassessment\tO\nof\tO\nthe\tO\neffects\tT-1\nof\tT-1\nE4031\tO\n,\tO\ncisapride\tO\n,\tO\nterfenadine\tO\nand\tO\nterodiline\tB-Chemical\non\tO\nmonophasic\tT-0\naction\tT-0\npotential\tO\nduration\tO\nin\tO\ndog\tO\n.\tO\n\nTorsades\tB-Disease\nde\tI-Disease\npointes\tI-Disease\n(\tO\nTDP\tO\n)\tO\nis\tO\na\tO\npotentially\tT-0\nfatal\tO\nventricular\tO\ntachycardia\tO\nassociated\tT-1\nwith\tO\nincreases\tO\nin\tO\nQT\tO\ninterval\tO\nand\tO\nmonophasic\tO\naction\tO\npotential\tO\nduration\tO\n(\tO\nMAPD\tO\n)\tO\n.\tO\n\nTorsades\tO\nde\tO\npointes\tO\n(\tO\nTDP\tB-Disease\n)\tO\nis\tT-1\na\tT-1\npotentially\tO\nfatal\tO\nventricular\tO\ntachycardia\tO\nassociated\tO\nwith\tO\nincreases\tO\nin\tO\nQT\tO\ninterval\tO\nand\tO\nmonophasic\tO\naction\tO\npotential\tO\nduration\tO\n(\tO\nMAPD\tO\n)\tO\n.\tT-0\n\nTDP\tB-Disease\nis\tO\na\tO\nside\tT-0\n-\tT-0\neffect\tT-0\nthat\tO\nhas\tO\nled\tO\nto\tO\nwithdrawal\tT-1\nof\tO\nseveral\tO\ndrugs\tO\nfrom\tO\nthe\tO\nmarket\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\nterfenadine\tO\nand\tO\nterodiline\tO\n)\tO\n.\tO\n\nTDP\tO\nis\tO\na\tO\nside\tT-1\n-\tT-1\neffect\tT-1\nthat\tO\nhas\tO\nled\tT-2\nto\tT-2\nwithdrawal\tT-2\nof\tT-0\nseveral\tO\ndrugs\tO\nfrom\tO\nthe\tO\nmarket\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\nterfenadine\tB-Chemical\nand\tO\nterodiline\tO\n)\tO\n.\tO\n\nTDP\tO\nis\tO\na\tO\nside\tT-0\n-\tT-0\neffect\tT-0\nthat\tO\nhas\tO\nled\tO\nto\tO\nwithdrawal\tO\nof\tO\nseveral\tO\ndrugs\tT-1\nfrom\tO\nthe\tO\nmarket\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\nterfenadine\tO\nand\tT-2\nterodiline\tB-Chemical\n)\tO\n.\tO\n\nThe\tO\npotential\tO\nof\tO\ncompounds\tO\nto\tO\ncause\tT-0\nTDP\tB-Disease\nwas\tO\nevaluated\tT-1\nby\tO\nmonitoring\tO\ntheir\tO\neffects\tT-2\non\tO\nMAPD\tO\nin\tO\ndog\tO\n.\tO\n\nFour\tO\ncompounds\tO\nknown\tO\nto\tO\nincrease\tO\nQT\tO\ninterval\tO\nand\tO\ncause\tT-0\nTDP\tB-Disease\nwere\tO\ninvestigated\tO\n:\tO\nterfenadine\tO\n,\tO\nterodiline\tO\n,\tO\ncisapride\tO\nand\tO\nE4031\tO\n.\tO\n\nFour\tO\ncompounds\tT-0\nknown\tT-0\nto\tT-0\nincrease\tT-0\nQT\tO\ninterval\tO\nand\tO\ncause\tO\nTDP\tO\nwere\tO\ninvestigated\tO\n:\tO\nterfenadine\tB-Chemical\n,\tO\nterodiline\tO\n,\tO\ncisapride\tO\nand\tO\nE4031\tO\n.\tO\n\nFour\tO\ncompounds\tT-2\nknown\tO\nto\tO\nincrease\tT-0\nQT\tO\ninterval\tO\nand\tO\ncause\tT-1\nTDP\tO\nwere\tO\ninvestigated\tT-3\n:\tO\nterfenadine\tO\n,\tO\nterodiline\tB-Chemical\n,\tO\ncisapride\tO\nand\tO\nE4031\tO\n.\tO\n\nFour\tO\ncompounds\tO\nknown\tO\nto\tO\nincrease\tO\nQT\tO\ninterval\tO\nand\tO\ncause\tO\nTDP\tO\nwere\tO\ninvestigated\tO\n:\tO\nterfenadine\tO\n,\tO\nterodiline\tT-0\n,\tO\ncisapride\tB-Chemical\nand\tT-1\nE4031\tT-1\n.\tO\n\nFour\tT-0\ncompounds\tT-0\nknown\tO\nto\tT-1\nincrease\tT-1\nQT\tO\ninterval\tO\nand\tO\ncause\tT-2\nTDP\tO\nwere\tT-3\ninvestigated\tT-3\n:\tO\nterfenadine\tO\n,\tO\nterodiline\tO\n,\tO\ncisapride\tO\nand\tO\nE4031\tB-Chemical\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nthe\tO\nfree\tO\nED50\tO\nin\tT-1\nplasma\tT-1\nfor\tT-0\nterfenadine\tB-Chemical\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\n,\tO\nterodiline\tO\n(\tO\n76\tO\nnM\tO\n)\tO\n,\tO\ncisapride\tO\n(\tO\n11\tO\nnM\tO\n)\tO\nand\tO\nE4031\tO\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\nclosely\tO\ncorrelate\tO\nwith\tO\nthe\tO\nfree\tO\nconcentration\tO\nin\tO\nman\tO\ncausing\tO\nQT\tO\neffects\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tO\nthat\tO\nthe\tO\nfree\tO\nED50\tO\nin\tO\nplasma\tO\nfor\tO\nterfenadine\tO\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\n,\tO\nterodiline\tB-Chemical\n(\tO\n76\tO\nnM\tO\n)\tO\n,\tO\ncisapride\tO\n(\tO\n11\tO\nnM\tO\n)\tO\nand\tO\nE4031\tO\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\nclosely\tO\ncorrelate\tT-0\nwith\tT-0\nthe\tO\nfree\tO\nconcentration\tO\nin\tO\nman\tO\ncausing\tO\nQT\tO\neffects\tO\n.\tO\n\nThese\tT-0\ndata\tT-0\nindicate\tT-0\nthat\tO\nthe\tO\nfree\tO\nED50\tO\nin\tO\nplasma\tO\nfor\tO\nterfenadine\tO\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\n,\tO\nterodiline\tT-1\n(\tT-1\n76\tT-1\nnM\tT-1\n)\tT-1\n,\tO\ncisapride\tB-Chemical\n(\tO\n11\tO\nnM\tO\n)\tO\nand\tT-2\nE4031\tT-2\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\nclosely\tO\ncorrelate\tO\nwith\tO\nthe\tO\nfree\tO\nconcentration\tO\nin\tO\nman\tO\ncausing\tO\nQT\tO\neffects\tO\n.\tO\n\nThese\tO\ndata\tO\nindicate\tT-3\nthat\tO\nthe\tO\nfree\tT-0\nED50\tT-0\nin\tT-0\nplasma\tT-0\nfor\tT-0\nterfenadine\tT-0\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\n,\tO\nterodiline\tT-1\n(\tT-1\n76\tT-1\nnM\tT-1\n)\tT-1\n,\tT-1\ncisapride\tT-1\n(\tT-1\n11\tT-1\nnM\tT-1\n)\tT-1\nand\tT-2\nE4031\tB-Chemical\n(\tO\n1\tO\n.\tO\n9\tO\nnM\tO\n)\tO\nclosely\tO\ncorrelate\tT-4\nwith\tO\nthe\tO\nfree\tO\nconcentration\tO\nin\tO\nman\tO\ncausing\tO\nQT\tO\neffects\tT-5\n.\tO\n\nFor\tO\ncompounds\tO\nthat\tT-1\nhave\tT-1\nshown\tT-1\nTDP\tB-Disease\nin\tT-2\nthe\tT-2\nclinic\tT-2\n(\tO\nterfenadine\tO\n,\tO\nterodiline\tO\n,\tO\ncisapride\tO\n)\tO\nthere\tO\nis\tO\nlittle\tO\ndifferentiation\tO\nbetween\tO\nthe\tO\ndog\tO\nED50\tO\nand\tO\nthe\tO\nefficacious\tO\nfree\tO\nplasma\tO\nconcentrations\tO\nin\tO\nman\tO\n(\tO\n<\tO\n10\tO\n-\tO\nfold\tO\n)\tO\nreflecting\tO\ntheir\tO\nlimited\tO\nsafety\tO\nmargins\tO\n.\tO\n\nFor\tO\ncompounds\tT-0\nthat\tO\nhave\tO\nshown\tO\nTDP\tO\nin\tO\nthe\tO\nclinic\tO\n(\tO\nterfenadine\tB-Chemical\n,\tO\nterodiline\tO\n,\tO\ncisapride\tO\n)\tO\nthere\tO\nis\tO\nlittle\tO\ndifferentiation\tT-1\nbetween\tO\nthe\tO\ndog\tO\nED50\tO\nand\tO\nthe\tO\nefficacious\tO\nfree\tO\nplasma\tO\nconcentrations\tT-2\nin\tO\nman\tO\n(\tO\n<\tO\n10\tO\n-\tO\nfold\tO\n)\tO\nreflecting\tO\ntheir\tO\nlimited\tO\nsafety\tO\nmargins\tO\n.\tO\n\nFor\tO\ncompounds\tT-0\nthat\tO\nhave\tO\nshown\tO\nTDP\tO\nin\tO\nthe\tO\nclinic\tO\n(\tO\nterfenadine\tO\n,\tO\nterodiline\tB-Chemical\n,\tO\ncisapride\tO\n)\tO\nthere\tO\nis\tO\nlittle\tO\ndifferentiation\tO\nbetween\tO\nthe\tO\ndog\tO\nED50\tO\nand\tO\nthe\tO\nefficacious\tO\nfree\tO\nplasma\tO\nconcentrations\tO\nin\tO\nman\tO\n(\tO\n<\tO\n10\tO\n-\tO\nfold\tO\n)\tO\nreflecting\tO\ntheir\tO\nlimited\tO\nsafety\tO\nmargins\tO\n.\tO\n\nFor\tO\ncompounds\tO\nthat\tO\nhave\tO\nshown\tT-0\nTDP\tT-0\nin\tO\nthe\tO\nclinic\tO\n(\tO\nterfenadine\tO\n,\tO\nterodiline\tO\n,\tO\ncisapride\tB-Chemical\n)\tO\nthere\tT-1\nis\tT-1\nlittle\tT-1\ndifferentiation\tT-1\nbetween\tO\nthe\tO\ndog\tO\nED50\tO\nand\tO\nthe\tO\nefficacious\tO\nfree\tO\nplasma\tO\nconcentrations\tO\nin\tO\nman\tO\n(\tO\n<\tO\n10\tO\n-\tO\nfold\tO\n)\tO\nreflecting\tO\ntheir\tO\nlimited\tO\nsafety\tO\nmargins\tO\n.\tO\n\nThese\tO\ndata\tO\nunderline\tO\nthe\tO\nneed\tO\nto\tO\nmaximize\tO\nthe\tO\ntherapeutic\tT-0\nratio\tT-0\nwith\tO\nrespect\tO\nto\tO\nTDP\tB-Disease\nin\tO\npotential\tO\ndevelopment\tO\ncandidates\tO\nand\tO\nthe\tO\nimportance\tO\nof\tO\nusing\tO\nfree\tO\ndrug\tO\nconcentrations\tO\nin\tO\npharmacokinetic\tO\n/\tO\npharmacodynamic\tO\nstudies\tO\n.\tO\n\nBladder\tT-0\nretention\tB-Disease\nof\tI-Disease\nurine\tI-Disease\nas\tT-1\na\tT-1\nresult\tT-1\nof\tO\ncontinuous\tO\nintravenous\tO\ninfusion\tO\nof\tO\nfentanyl\tO\n:\tO\n2\tO\ncase\tT-2\nreports\tT-2\n.\tO\n\nBladder\tO\nretention\tO\nof\tO\nurine\tO\nas\tO\na\tO\nresult\tO\nof\tO\ncontinuous\tO\nintravenous\tO\ninfusion\tT-1\nof\tT-1\nfentanyl\tB-Chemical\n:\tO\n2\tO\ncase\tO\nreports\tO\n.\tO\n\nSedation\tO\nhas\tO\nbeen\tO\ncommonly\tO\nused\tO\nin\tO\nthe\tO\nneonate\tO\nto\tO\ndecrease\tT-1\nthe\tT-1\nstress\tO\nand\tO\npain\tB-Disease\nfrom\tT-2\nthe\tO\nnoxious\tO\nstimuli\tO\nand\tO\ninvasive\tO\nprocedures\tO\nin\tO\nthe\tO\nneonatal\tO\nintensive\tO\ncare\tO\nunit\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nto\tO\nfacilitate\tO\nsynchrony\tO\nbetween\tO\nventilator\tO\nand\tO\nspontaneous\tO\nbreaths\tO\n.\tO\n\nFentanyl\tB-Chemical\n,\tO\nan\tT-0\nopioid\tT-0\nanalgesic\tT-0\n,\tO\nis\tO\nfrequently\tO\nused\tO\nin\tO\nthe\tO\nneonatal\tO\nintensive\tO\ncare\tO\nunit\tO\nsetting\tO\nfor\tO\nthese\tO\nvery\tO\npurposes\tO\n.\tO\n\nVarious\tO\nreported\tO\nside\tT-1\neffects\tT-1\nof\tT-0\nfentanyl\tB-Chemical\nadministration\tT-2\ninclude\tO\nchest\tO\nwall\tO\nrigidity\tO\n,\tO\nhypotension\tO\n,\tO\nrespiratory\tO\ndepression\tO\n,\tO\nand\tO\nbradycardia\tO\n.\tO\n\nVarious\tO\nreported\tO\nside\tO\neffects\tO\nof\tO\nfentanyl\tO\nadministration\tT-3\ninclude\tT-3\nchest\tB-Disease\nwall\tI-Disease\nrigidity\tI-Disease\n,\tO\nhypotension\tT-1\n,\tO\nrespiratory\tT-2\ndepression\tO\n,\tO\nand\tO\nbradycardia\tO\n.\tT-2\n\nVarious\tT-2\nreported\tT-2\nside\tT-2\neffects\tT-2\nof\tO\nfentanyl\tO\nadministration\tO\ninclude\tT-3\nchest\tT-0\nwall\tT-0\nrigidity\tT-0\n,\tO\nhypotension\tB-Disease\n,\tO\nrespiratory\tT-1\ndepression\tT-1\n,\tO\nand\tO\nbradycardia\tO\n.\tO\n\nVarious\tO\nreported\tO\nside\tO\neffects\tO\nof\tO\nfentanyl\tO\nadministration\tO\ninclude\tO\nchest\tO\nwall\tO\nrigidity\tO\n,\tO\nhypotension\tT-0\n,\tO\nrespiratory\tB-Disease\ndepression\tI-Disease\n,\tO\nand\tT-1\nbradycardia\tT-1\n.\tO\n\nVarious\tO\nreported\tO\nside\tO\neffects\tO\nof\tO\nfentanyl\tO\nadministration\tO\ninclude\tO\nchest\tO\nwall\tO\nrigidity\tO\n,\tO\nhypotension\tO\n,\tO\nrespiratory\tO\ndepression\tO\n,\tO\nand\tT-0\nbradycardia\tB-Disease\n.\tO\n\nHere\tO\n,\tO\n2\tT-1\ncases\tT-1\nof\tT-1\nurinary\tB-Disease\nbladder\tI-Disease\nretention\tI-Disease\nleading\tO\nto\tO\nrenal\tO\npelvocalyceal\tO\ndilatation\tO\nmimicking\tO\nhydronephrosis\tO\nas\tO\na\tO\nresult\tO\nof\tO\ncontinuous\tO\ninfusion\tO\nof\tO\nfentanyl\tO\nare\tO\nreported\tO\n.\tO\n\nHere\tO\n,\tO\n2\tO\ncases\tO\nof\tO\nurinary\tO\nbladder\tO\nretention\tO\nleading\tO\nto\tO\nrenal\tO\npelvocalyceal\tO\ndilatation\tO\nmimicking\tO\nhydronephrosis\tB-Disease\nas\tT-0\na\tT-0\nresult\tT-0\nof\tT-0\ncontinuous\tT-0\ninfusion\tT-0\nof\tO\nfentanyl\tO\nare\tO\nreported\tO\n.\tO\n\nHere\tO\n,\tO\n2\tO\ncases\tO\nof\tO\nurinary\tO\nbladder\tO\nretention\tO\nleading\tO\nto\tO\nrenal\tO\npelvocalyceal\tO\ndilatation\tO\nmimicking\tO\nhydronephrosis\tO\nas\tO\na\tO\nresult\tO\nof\tO\ncontinuous\tO\ninfusion\tT-0\nof\tT-0\nfentanyl\tB-Chemical\nare\tO\nreported\tO\n.\tO\n\nFatal\tT-1\nmyeloencephalopathy\tB-Disease\ndue\tT-0\nto\tT-0\naccidental\tO\nintrathecal\tO\nvincristin\tO\nadministration\tO\n:\tO\na\tO\nreport\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nFatal\tO\nmyeloencephalopathy\tO\ndue\tO\nto\tO\naccidental\tT-0\nintrathecal\tT-0\nvincristin\tB-Chemical\nadministration\tT-1\n:\tO\na\tO\nreport\tO\nof\tO\ntwo\tO\ncases\tO\n.\tO\n\nWe\tO\nreport\tO\non\tO\ntwo\tO\nfatal\tO\ncases\tO\nof\tO\naccidental\tO\nintrathecal\tT-0\nvincristine\tB-Chemical\ninstillation\tT-1\nin\tO\na\tO\n5\tO\n-\tO\nyear\tO\nold\tO\ngirl\tO\nwith\tO\nrecurrent\tO\nacute\tO\nlymphoblastic\tO\nleucemia\tO\nand\tO\na\tO\n57\tO\n-\tO\nyear\tO\nold\tO\nman\tO\nwith\tO\nlymphoblastic\tO\nlymphoma\tO\n.\tO\n\nWe\tO\nreport\tO\non\tO\ntwo\tO\nfatal\tO\ncases\tO\nof\tO\naccidental\tO\nintrathecal\tO\nvincristine\tO\ninstillation\tO\nin\tO\na\tO\n5\tO\n-\tO\nyear\tO\nold\tO\ngirl\tO\nwith\tO\nrecurrent\tT-0\nacute\tB-Disease\nlymphoblastic\tI-Disease\nleucemia\tI-Disease\nand\tO\na\tO\n57\tO\n-\tO\nyear\tO\nold\tO\nman\tO\nwith\tO\nlymphoblastic\tO\nlymphoma\tO\n.\tO\n\nWe\tO\nreport\tO\non\tO\ntwo\tO\nfatal\tO\ncases\tO\nof\tO\naccidental\tO\nintrathecal\tO\nvincristine\tO\ninstillation\tO\nin\tO\na\tO\n5\tO\n-\tO\nyear\tO\nold\tO\ngirl\tO\nwith\tO\nrecurrent\tO\nacute\tO\nlymphoblastic\tO\nleucemia\tO\nand\tO\na\tO\n57\tO\n-\tO\nyear\tO\nold\tT-0\nman\tT-0\nwith\tT-0\nlymphoblastic\tB-Disease\nlymphoma\tI-Disease\n.\tO\n\nThe\tO\ngirl\tO\ndied\tT-0\nseven\tT-0\ndays\tT-0\n,\tO\nthe\tO\nman\tO\nfour\tO\nweeks\tO\nafter\tT-1\nintrathecal\tT-1\ninjection\tT-1\nof\tT-1\nvincristine\tB-Chemical\n.\tO\n\nClinically\tO\n,\tO\nthe\tO\nonset\tO\nwas\tO\ncharacterized\tT-0\nby\tT-0\nthe\tT-0\nsigns\tT-0\nof\tT-0\nopistothonus\tB-Disease\n,\tI-Disease\nsensory\tI-Disease\nand\tI-Disease\nmotor\tI-Disease\ndysfunction\tI-Disease\nand\tO\nascending\tO\nparalysis\tO\n.\tO\n\nClinically\tO\n,\tO\nthe\tO\nonset\tO\nwas\tO\ncharacterized\tO\nby\tO\nthe\tO\nsigns\tO\nof\tO\nopistothonus\tO\n,\tO\nsensory\tO\nand\tO\nmotor\tO\ndysfunction\tO\nand\tT-0\nascending\tT-0\nparalysis\tB-Disease\n.\tO\n\nHistological\tO\nand\tO\nimmunohistochemical\tO\ninvestigations\tT-0\n(\tO\nHE\tO\n-\tO\nLFB\tO\n,\tO\nCD\tO\n-\tO\n68\tO\n,\tO\nNeurofilament\tO\n)\tO\nrevealed\tT-1\ndegeneration\tB-Disease\nof\tI-Disease\nmyelin\tI-Disease\nand\tI-Disease\naxons\tI-Disease\nas\tO\nwell\tO\nas\tO\npseudocystic\tO\ntransformation\tO\nin\tO\nareas\tO\nexposed\tO\nto\tO\nvincristine\tO\n,\tO\naccompanied\tO\nby\tO\nsecondary\tO\nchanges\tO\nwith\tO\nnumerous\tO\nprominent\tO\nmacrophages\tT-2\n.\tT-2\n\nHistological\tO\nand\tO\nimmunohistochemical\tO\ninvestigations\tO\n(\tO\nHE\tO\n-\tO\nLFB\tO\n,\tO\nCD\tO\n-\tO\n68\tO\n,\tO\nNeurofilament\tO\n)\tO\nrevealed\tT-0\ndegeneration\tO\nof\tO\nmyelin\tO\nand\tO\naxons\tO\nas\tO\nwell\tO\nas\tO\npseudocystic\tB-Disease\ntransformation\tI-Disease\nin\tO\nareas\tO\nexposed\tT-1\nto\tO\nvincristine\tO\n,\tO\naccompanied\tO\nby\tO\nsecondary\tO\nchanges\tO\nwith\tO\nnumerous\tO\nprominent\tO\nmacrophages\tO\n.\tO\n\nHistological\tO\nand\tO\nimmunohistochemical\tO\ninvestigations\tO\n(\tO\nHE\tO\n-\tO\nLFB\tO\n,\tO\nCD\tO\n-\tO\n68\tO\n,\tO\nNeurofilament\tO\n)\tO\nrevealed\tO\ndegeneration\tO\nof\tO\nmyelin\tO\nand\tO\naxons\tO\nas\tO\nwell\tO\nas\tO\npseudocystic\tO\ntransformation\tO\nin\tO\nareas\tO\nexposed\tT-0\nto\tT-0\nvincristine\tB-Chemical\n,\tO\naccompanied\tT-1\nby\tT-1\nsecondary\tO\nchanges\tO\nwith\tO\nnumerous\tO\nprominent\tO\nmacrophages\tO\n.\tO\n\nA\tO\nbetter\tT-2\ncontrolled\tT-2\nregimen\tT-2\nfor\tT-2\nadministering\tT-2\nvincristine\tB-Chemical\nand\tT-1\nintrathecal\tT-3\nchemotherapy\tT-3\nis\tT-3\nrecommended\tT-3\n.\tT-3\n\nPalpebral\tO\ntwitching\tO\nin\tT-0\na\tT-0\ndepressed\tB-Disease\nadolescent\tO\non\tO\ncitalopram\tO\n.\tO\n\nPalpebral\tO\ntwitching\tO\nin\tO\na\tO\ndepressed\tO\nadolescent\tT-0\non\tT-0\ncitalopram\tB-Chemical\n.\tO\n\nCurrent\tO\nestimates\tO\nsuggest\tO\nthat\tO\nbetween\tO\n0\tO\n.\tO\n4\tO\n%\tO\nand\tO\n8\tO\n.\tO\n3\tO\n%\tO\nof\tO\nchildren\tT-0\nand\tT-0\nadolescents\tT-0\nare\tT-0\naffected\tT-0\nby\tT-0\nmajor\tB-Disease\ndepression\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\nfavorable\tO\nresponse\tO\nto\tT-0\ntreatment\tT-0\nwith\tT-0\ncitalopram\tB-Chemical\nby\tT-1\na\tT-1\n15\tT-1\n-\tT-1\nyear\tT-1\n-\tO\nold\tO\nboy\tO\nwith\tO\nmajor\tO\ndepression\tO\nwho\tO\nexhibited\tO\npalpebral\tO\ntwitching\tO\nduring\tO\nhis\tO\nfirst\tO\n2\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\nfavorable\tO\nresponse\tT-0\nto\tO\ntreatment\tO\nwith\tO\ncitalopram\tO\nby\tO\na\tO\n15\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwith\tO\nmajor\tB-Disease\ndepression\tI-Disease\nwho\tO\nexhibited\tT-1\npalpebral\tO\ntwitching\tO\nduring\tO\nhis\tO\nfirst\tO\n2\tO\nweeks\tO\nof\tO\ntreatment\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\nfavorable\tT-0\nresponse\tT-0\nto\tT-0\ntreatment\tT-0\nwith\tO\ncitalopram\tO\nby\tO\na\tO\n15\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nboy\tO\nwith\tO\nmajor\tO\ndepression\tO\nwho\tO\nexhibited\tT-3\npalpebral\tB-Disease\ntwitching\tI-Disease\nduring\tO\nhis\tO\nfirst\tT-2\n2\tT-2\nweeks\tT-2\nof\tT-2\ntreatment\tT-2\n.\tO\n\nThis\tO\nmay\tO\nhave\tO\nbeen\tO\na\tO\nside\tT-1\neffect\tT-1\nof\tT-1\ncitalopram\tB-Chemical\nas\tT-0\nit\tT-0\nremitted\tT-0\nwith\tO\nredistribution\tO\nof\tO\ndoses\tO\n.\tO\n\nThe\tO\n3\tO\n-\tO\nweek\tO\nsulphasalazine\tB-Chemical\nsyndrome\tT-0\nstrikes\tT-1\nagain\tT-1\n.\tO\n\nA\tO\n34\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nlady\tO\ndeveloped\tT-2\na\tT-2\nconstellation\tT-2\nof\tT-2\ndermatitis\tB-Disease\n,\tO\nfever\tT-1\n,\tO\nlymphadenopathy\tO\nand\tO\nhepatitis\tO\n,\tO\nbeginning\tO\non\tO\nthe\tO\n17th\tO\nday\tO\nof\tO\na\tO\ncourse\tO\nof\tO\noral\tO\nsulphasalazine\tO\nfor\tO\nsero\tO\n-\tO\nnegative\tO\nrheumatoid\tO\narthritis\tO\n.\tO\n\nA\tO\n34\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nlady\tO\ndeveloped\tT-1\na\tO\nconstellation\tO\nof\tO\ndermatitis\tO\n,\tO\nfever\tB-Disease\n,\tO\nlymphadenopathy\tO\nand\tO\nhepatitis\tO\n,\tO\nbeginning\tO\non\tO\nthe\tO\n17th\tO\nday\tO\nof\tO\na\tO\ncourse\tT-0\nof\tT-0\noral\tT-0\nsulphasalazine\tT-0\nfor\tT-0\nsero\tT-0\n-\tO\nnegative\tO\nrheumatoid\tO\narthritis\tO\n.\tO\n\nA\tO\n34\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nlady\tO\ndeveloped\tT-0\na\tT-0\nconstellation\tO\nof\tO\ndermatitis\tO\n,\tO\nfever\tT-1\n,\tO\nlymphadenopathy\tB-Disease\nand\tT-2\nhepatitis\tT-2\n,\tO\nbeginning\tO\non\tO\nthe\tO\n17th\tO\nday\tO\nof\tO\na\tO\ncourse\tO\nof\tO\noral\tO\nsulphasalazine\tO\nfor\tO\nsero\tO\n-\tO\nnegative\tO\nrheumatoid\tO\narthritis\tO\n.\tO\n\nA\tO\n34\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nlady\tO\ndeveloped\tO\na\tO\nconstellation\tO\nof\tO\ndermatitis\tO\n,\tO\nfever\tO\n,\tO\nlymphadenopathy\tO\nand\tO\nhepatitis\tO\n,\tO\nbeginning\tO\non\tO\nthe\tO\n17th\tO\nday\tO\nof\tO\na\tO\ncourse\tT-1\nof\tT-1\noral\tT-1\nsulphasalazine\tB-Chemical\nfor\tO\nsero\tO\n-\tO\nnegative\tO\nrheumatoid\tO\narthritis\tO\n.\tO\n\nA\tO\n34\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nlady\tO\ndeveloped\tO\na\tO\nconstellation\tO\nof\tO\ndermatitis\tO\n,\tO\nfever\tO\n,\tO\nlymphadenopathy\tO\nand\tO\nhepatitis\tO\n,\tO\nbeginning\tO\non\tO\nthe\tO\n17th\tO\nday\tO\nof\tO\na\tO\ncourse\tO\nof\tO\noral\tO\nsulphasalazine\tO\nfor\tO\nsero\tO\n-\tO\nnegative\tT-0\nrheumatoid\tB-Disease\narthritis\tI-Disease\n.\tO\n\nCervical\tO\nand\tO\ninguinal\tO\nlymph\tO\nnode\tO\nbiopsies\tO\nshowed\tO\nthe\tO\nfeatures\tT-2\nof\tT-2\nsevere\tT-2\nnecrotising\tT-2\nlymphadenitis\tB-Disease\n,\tO\nassociated\tO\nwith\tO\nerythrophagocytosis\tO\nand\tO\nprominent\tO\neosinophilic\tO\ninfiltrates\tO\n,\tO\nwithout\tO\nviral\tO\ninclusion\tO\nbodies\tO\n,\tO\nsuggestive\tO\nof\tO\nan\tO\nadverse\tO\ndrug\tO\nreaction\tO\n.\tO\nA\tO\nweek\tO\nlater\tO\n,\tO\nfulminant\tO\ndrug\tO\n-\tO\ninduced\tO\nhepatitis\tO\n,\tO\nassociated\tO\nwith\tO\nthe\tO\npresence\tO\nof\tO\nanti\tO\n-\tO\nnuclear\tO\nautoantibodies\tO\n(\tO\nbut\tO\nnot\tO\nwith\tO\nother\tO\nmarkers\tO\nof\tO\nautoimmunity\tO\n)\tO\n,\tO\nand\tO\naccompanied\tO\nby\tO\nmulti\tT-1\n-\tT-1\norgan\tT-1\nfailure\tT-1\nand\tO\nsepsis\tO\n,\tO\nsupervened\tO\n.\tO\n\nCervical\tO\nand\tO\ninguinal\tO\nlymph\tO\nnode\tO\nbiopsies\tO\nshowed\tO\nthe\tO\nfeatures\tO\nof\tO\nsevere\tO\nnecrotising\tO\nlymphadenitis\tO\n,\tO\nassociated\tO\nwith\tO\nerythrophagocytosis\tO\nand\tO\nprominent\tO\neosinophilic\tO\ninfiltrates\tO\n,\tO\nwithout\tO\nviral\tO\ninclusion\tO\nbodies\tO\n,\tO\nsuggestive\tO\nof\tO\nan\tO\nadverse\tB-Disease\ndrug\tI-Disease\nreaction\tI-Disease\n.\tO\nA\tO\nweek\tO\nlater\tO\n,\tO\nfulminant\tO\ndrug\tO\n-\tO\ninduced\tO\nhepatitis\tO\n,\tO\nassociated\tO\nwith\tO\nthe\tO\npresence\tO\nof\tO\nanti\tO\n-\tO\nnuclear\tO\nautoantibodies\tO\n(\tO\nbut\tO\nnot\tO\nwith\tO\nother\tO\nmarkers\tO\nof\tO\nautoimmunity\tO\n)\tO\n,\tO\nand\tO\naccompanied\tO\nby\tO\nmulti\tT-0\n-\tT-0\norgan\tT-0\nfailure\tT-0\nand\tO\nsepsis\tO\n,\tO\nsupervened\tO\n.\tO\n\nCervical\tT-0\nand\tT-0\ninguinal\tT-0\nlymph\tT-0\nnode\tT-0\nbiopsies\tT-0\nshowed\tO\nthe\tO\nfeatures\tO\nof\tO\nsevere\tO\nnecrotising\tO\nlymphadenitis\tO\n,\tO\nassociated\tO\nwith\tO\nerythrophagocytosis\tO\nand\tO\nprominent\tO\neosinophilic\tO\ninfiltrates\tO\n,\tO\nwithout\tO\nviral\tO\ninclusion\tO\nbodies\tO\n,\tO\nsuggestive\tO\nof\tO\nan\tO\nadverse\tO\ndrug\tO\nreaction\tO\n.\tO\nA\tO\nweek\tO\nlater\tO\n,\tO\nfulminant\tO\ndrug\tB-Disease\n-\tI-Disease\ninduced\tI-Disease\nhepatitis\tI-Disease\n,\tO\nassociated\tT-1\nwith\tO\nthe\tO\npresence\tO\nof\tO\nanti\tO\n-\tO\nnuclear\tO\nautoantibodies\tO\n(\tO\nbut\tO\nnot\tO\nwith\tO\nother\tO\nmarkers\tO\nof\tO\nautoimmunity\tO\n)\tO\n,\tO\nand\tO\naccompanied\tO\nby\tO\nmulti\tO\n-\tO\norgan\tO\nfailure\tO\nand\tO\nsepsis\tO\n,\tO\nsupervened\tO\n.\tO\n\nCervical\tO\nand\tO\ninguinal\tO\nlymph\tO\nnode\tO\nbiopsies\tO\nshowed\tO\nthe\tO\nfeatures\tO\nof\tO\nsevere\tO\nnecrotising\tO\nlymphadenitis\tO\n,\tO\nassociated\tO\nwith\tO\nerythrophagocytosis\tO\nand\tO\nprominent\tO\neosinophilic\tO\ninfiltrates\tO\n,\tO\nwithout\tO\nviral\tO\ninclusion\tO\nbodies\tO\n,\tO\nsuggestive\tO\nof\tO\nan\tO\nadverse\tO\ndrug\tO\nreaction\tO\n.\tO\nA\tO\nweek\tO\nlater\tO\n,\tO\nfulminant\tO\ndrug\tO\n-\tO\ninduced\tO\nhepatitis\tO\n,\tO\nassociated\tO\nwith\tO\nthe\tO\npresence\tO\nof\tO\nanti\tO\n-\tO\nnuclear\tO\nautoantibodies\tO\n(\tO\nbut\tO\nnot\tO\nwith\tO\nother\tT-0\nmarkers\tT-0\nof\tT-0\nautoimmunity\tB-Disease\n)\tO\n,\tO\nand\tT-1\naccompanied\tT-1\nby\tO\nmulti\tO\n-\tO\norgan\tO\nfailure\tO\nand\tO\nsepsis\tO\n,\tO\nsupervened\tO\n.\tO\n\nCervical\tO\nand\tO\ninguinal\tO\nlymph\tO\nnode\tO\nbiopsies\tO\nshowed\tO\nthe\tO\nfeatures\tO\nof\tO\nsevere\tO\nnecrotising\tO\nlymphadenitis\tO\n,\tO\nassociated\tO\nwith\tO\nerythrophagocytosis\tO\nand\tO\nprominent\tO\neosinophilic\tO\ninfiltrates\tO\n,\tO\nwithout\tO\nviral\tO\ninclusion\tO\nbodies\tO\n,\tO\nsuggestive\tO\nof\tO\nan\tO\nadverse\tO\ndrug\tO\nreaction\tO\n.\tO\nA\tO\nweek\tO\nlater\tO\n,\tO\nfulminant\tO\ndrug\tO\n-\tO\ninduced\tO\nhepatitis\tO\n,\tO\nassociated\tO\nwith\tO\nthe\tO\npresence\tO\nof\tO\nanti\tO\n-\tO\nnuclear\tO\nautoantibodies\tO\n(\tO\nbut\tO\nnot\tO\nwith\tO\nother\tO\nmarkers\tO\nof\tO\nautoimmunity\tO\n)\tO\n,\tO\nand\tO\naccompanied\tT-0\nby\tT-0\nmulti\tB-Disease\n-\tI-Disease\norgan\tI-Disease\nfailure\tI-Disease\nand\tO\nsepsis\tO\n,\tO\nsupervened\tO\n.\tO\n\nCervical\tO\nand\tO\ninguinal\tO\nlymph\tO\nnode\tO\nbiopsies\tO\nshowed\tO\nthe\tO\nfeatures\tO\nof\tO\nsevere\tO\nnecrotising\tO\nlymphadenitis\tO\n,\tO\nassociated\tO\nwith\tO\nerythrophagocytosis\tO\nand\tO\nprominent\tO\neosinophilic\tO\ninfiltrates\tO\n,\tO\nwithout\tO\nviral\tO\ninclusion\tO\nbodies\tO\n,\tO\nsuggestive\tO\nof\tO\nan\tO\nadverse\tO\ndrug\tO\nreaction\tO\n.\tO\nA\tO\nweek\tO\nlater\tO\n,\tO\nfulminant\tO\ndrug\tT-3\n-\tT-3\ninduced\tT-3\nhepatitis\tT-3\n,\tO\nassociated\tO\nwith\tO\nthe\tO\npresence\tT-2\nof\tT-2\nanti\tO\n-\tO\nnuclear\tO\nautoantibodies\tO\n(\tO\nbut\tO\nnot\tO\nwith\tO\nother\tO\nmarkers\tO\nof\tO\nautoimmunity\tO\n)\tO\n,\tO\nand\tO\naccompanied\tO\nby\tO\nmulti\tT-4\n-\tT-4\norgan\tT-4\nfailure\tT-4\nand\tT-0\nsepsis\tB-Disease\n,\tO\nsupervened\tT-1\n.\tO\n\nShe\tO\nsubsequently\tO\ndied\tO\nsome\tO\n5\tO\nweeks\tO\nafter\tO\nthe\tO\ncommencement\tO\nof\tO\nher\tO\ndrug\tO\ntherapy\tO\n.\tO\nPost\tT-2\n-\tT-2\nmortem\tT-2\nexamination\tT-2\nshowed\tT-2\nevidence\tT-2\nof\tT-2\nmassive\tB-Disease\nhepatocellular\tI-Disease\nnecrosis\tI-Disease\n,\tO\nacute\tT-1\nhypersensitivity\tT-1\nmyocarditis\tT-1\n,\tO\nfocal\tO\nacute\tO\ntubulo\tO\n-\tO\ninterstitial\tO\nnephritis\tO\nand\tO\nextensive\tO\nbone\tO\nmarrow\tO\nnecrosis\tO\n,\tO\nwith\tO\nno\tO\nevidence\tO\nof\tO\nmalignancy\tO\n.\tO\n\nShe\tO\nsubsequently\tO\ndied\tO\nsome\tO\n5\tO\nweeks\tO\nafter\tO\nthe\tO\ncommencement\tO\nof\tO\nher\tO\ndrug\tO\ntherapy\tO\n.\tO\nPost\tO\n-\tO\nmortem\tO\nexamination\tO\nshowed\tO\nevidence\tO\nof\tO\nmassive\tO\nhepatocellular\tO\nnecrosis\tO\n,\tO\nacute\tO\nhypersensitivity\tO\nmyocarditis\tO\n,\tO\nfocal\tO\nacute\tO\ntubulo\tO\n-\tO\ninterstitial\tT-0\nnephritis\tB-Disease\nand\tT-1\nextensive\tT-1\nbone\tO\nmarrow\tO\nnecrosis\tO\n,\tO\nwith\tO\nno\tO\nevidence\tO\nof\tO\nmalignancy\tO\n.\tO\n\nShe\tO\nsubsequently\tO\ndied\tO\nsome\tO\n5\tO\nweeks\tO\nafter\tO\nthe\tO\ncommencement\tO\nof\tO\nher\tO\ndrug\tO\ntherapy\tO\n.\tO\nPost\tO\n-\tO\nmortem\tO\nexamination\tO\nshowed\tO\nevidence\tO\nof\tO\nmassive\tO\nhepatocellular\tO\nnecrosis\tO\n,\tO\nacute\tO\nhypersensitivity\tO\nmyocarditis\tO\n,\tO\nfocal\tO\nacute\tO\ntubulo\tO\n-\tO\ninterstitial\tO\nnephritis\tO\nand\tO\nextensive\tT-0\nbone\tB-Disease\nmarrow\tI-Disease\nnecrosis\tI-Disease\n,\tO\nwith\tO\nno\tO\nevidence\tO\nof\tO\nmalignancy\tO\n.\tO\n\nShe\tO\nsubsequently\tO\ndied\tO\nsome\tO\n5\tO\nweeks\tO\nafter\tO\nthe\tO\ncommencement\tO\nof\tO\nher\tO\ndrug\tO\ntherapy\tO\n.\tO\nPost\tO\n-\tO\nmortem\tO\nexamination\tO\nshowed\tO\nevidence\tO\nof\tO\nmassive\tO\nhepatocellular\tO\nnecrosis\tO\n,\tO\nacute\tO\nhypersensitivity\tO\nmyocarditis\tO\n,\tO\nfocal\tO\nacute\tO\ntubulo\tO\n-\tO\ninterstitial\tO\nnephritis\tO\nand\tO\nextensive\tO\nbone\tO\nmarrow\tO\nnecrosis\tO\n,\tO\nwith\tO\nno\tT-1\nevidence\tT-1\nof\tT-1\nmalignancy\tB-Disease\n.\tO\n\nIt\tO\nis\tO\nthought\tO\nthat\tO\nthe\tO\nclinico\tO\n-\tO\npathological\tO\nfeatures\tO\nand\tO\nchronology\tO\nof\tO\nthis\tO\ncase\tO\nbore\tO\nthe\tO\nhallmarks\tO\nof\tO\nthe\tO\nso\tO\n-\tO\ncalled\tT-0\n\"\tT-0\n3\tT-0\n-\tT-0\nweek\tT-0\nsulphasalazine\tB-Chemical\nsyndrome\tT-1\n\"\tO\n,\tO\na\tO\nrare\tO\n,\tO\nbut\tO\noften\tO\nfatal\tO\n,\tO\nimmunoallergic\tO\nreaction\tO\nto\tO\nsulphasalazine\tO\n.\tO\n\nIt\tO\nis\tO\nthought\tO\nthat\tO\nthe\tO\nclinico\tO\n-\tO\npathological\tO\nfeatures\tO\nand\tO\nchronology\tO\nof\tO\nthis\tO\ncase\tO\nbore\tO\nthe\tO\nhallmarks\tO\nof\tO\nthe\tO\nso\tO\n-\tO\ncalled\tO\n\"\tO\n3\tO\n-\tO\nweek\tO\nsulphasalazine\tO\nsyndrome\tO\n\"\tO\n,\tO\na\tO\nrare\tO\n,\tO\nbut\tO\noften\tO\nfatal\tO\n,\tO\nimmunoallergic\tT-1\nreaction\tT-1\nto\tT-1\nsulphasalazine\tB-Chemical\n.\tO\n\nIntravenous\tT-0\nadministration\tT-0\nof\tT-0\nprochlorperazine\tB-Chemical\nby\tO\n15\tO\n-\tO\nminute\tO\ninfusion\tO\nversus\tO\n2\tO\n-\tO\nminute\tO\nbolus\tO\ndoes\tO\nnot\tO\naffect\tO\nthe\tO\nincidence\tO\nof\tO\nakathisia\tO\n:\tO\na\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ncontrolled\tO\ntrial\tO\n.\tO\n\nIntravenous\tO\nadministration\tO\nof\tO\nprochlorperazine\tO\nby\tO\n15\tO\n-\tO\nminute\tO\ninfusion\tO\nversus\tO\n2\tO\n-\tO\nminute\tO\nbolus\tO\ndoes\tO\nnot\tO\naffect\tO\nthe\tO\nincidence\tT-0\nof\tT-0\nakathisia\tB-Disease\n:\tO\na\tO\nprospective\tO\n,\tO\nrandomized\tO\n,\tO\ncontrolled\tO\ntrial\tO\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nWe\tO\nsought\tO\nto\tO\ncompare\tO\nthe\tO\nrate\tO\nof\tO\nakathisia\tB-Disease\nafter\tO\nadministration\tO\nof\tO\nintravenous\tT-0\nprochlorperazine\tT-0\nas\tO\na\tO\n2\tO\n-\tO\nminute\tO\nbolus\tO\nor\tO\n15\tO\n-\tO\nminute\tO\ninfusion\tO\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nWe\tO\nsought\tO\nto\tO\ncompare\tO\nthe\tO\nrate\tO\nof\tO\nakathisia\tO\nafter\tO\nadministration\tO\nof\tT-0\nintravenous\tT-0\nprochlorperazine\tB-Chemical\nas\tO\na\tO\n2\tT-1\n-\tT-1\nminute\tT-1\nbolus\tT-1\nor\tT-1\n15\tT-1\n-\tT-1\nminute\tT-1\ninfusion\tT-1\n.\tO\n\nPatients\tO\naged\tO\n18\tO\nyears\tO\nor\tO\nolder\tO\ntreated\tT-0\nwith\tT-0\nprochlorperazine\tO\nfor\tT-1\nheadache\tB-Disease\n,\tO\nnausea\tO\n,\tO\nor\tO\nvomiting\tO\nwere\tO\neligible\tO\nfor\tO\ninclusion\tO\n.\tO\n\nPatients\tT-0\naged\tT-0\n18\tO\nyears\tO\nor\tO\nolder\tO\ntreated\tT-1\nwith\tO\nprochlorperazine\tO\nfor\tO\nheadache\tT-2\n,\tO\nnausea\tB-Disease\n,\tO\nor\tO\nvomiting\tT-3\nwere\tO\neligible\tO\nfor\tO\ninclusion\tO\n.\tO\n\nPatients\tT-0\naged\tO\n18\tO\nyears\tO\nor\tO\nolder\tO\ntreated\tO\nwith\tO\nprochlorperazine\tO\nfor\tO\nheadache\tO\n,\tO\nnausea\tO\n,\tO\nor\tO\nvomiting\tB-Disease\nwere\tO\neligible\tO\nfor\tO\ninclusion\tO\n.\tO\n\nStudy\tO\nparticipants\tO\nwere\tO\nrandomized\tO\nto\tO\nreceive\tT-1\n10\tO\nmg\tO\nof\tO\nprochlorperazine\tB-Chemical\nadministered\tT-2\nintravenously\tO\nby\tO\nmeans\tO\nof\tO\n2\tO\n-\tO\nminute\tO\npush\tO\n(\tO\nbolus\tO\ngroup\tO\n)\tO\nor\tO\n10\tT-0\nmg\tT-0\ndiluted\tT-0\nin\tT-0\n50\tT-0\nmL\tT-0\nof\tO\nnormal\tO\nsaline\tO\nsolution\tO\nadministered\tO\nby\tO\nmeans\tO\nof\tO\nintravenous\tO\ninfusion\tO\nduring\tO\na\tO\n15\tO\n-\tO\nminute\tO\nperiod\tO\n(\tO\ninfusion\tO\ngroup\tO\n)\tO\n.\tO\n\nThe\tO\nmain\tO\noutcome\tO\nwas\tO\nthe\tO\nnumber\tO\nof\tO\nstudy\tO\nparticipants\tO\nexperiencing\tT-1\nakathisia\tB-Disease\nwithin\tT-0\n60\tT-0\nminutes\tT-0\nof\tT-0\nadministration\tT-0\n.\tO\n\nAkathisia\tO\nwas\tO\ndefined\tO\nas\tO\neither\tO\na\tO\nspontaneous\tO\nreport\tO\nof\tO\nrestlessness\tO\nor\tO\nagitation\tB-Disease\nor\tO\na\tO\nchange\tO\nof\tO\n2\tO\nor\tO\nmore\tO\nin\tO\nthe\tO\npatient\tO\n-\tO\nreported\tT-0\nakathisia\tT-0\nrating\tT-0\nscale\tT-0\nand\tO\na\tO\nchange\tO\nof\tO\nat\tO\nleast\tO\n1\tO\nin\tO\nthe\tO\ninvestigator\tO\n-\tO\nobserved\tO\nakathisia\tO\nrating\tO\nscale\tO\n.\tO\n\nAkathisia\tO\nwas\tO\ndefined\tO\nas\tO\neither\tO\na\tO\nspontaneous\tO\nreport\tO\nof\tO\nrestlessness\tO\nor\tO\nagitation\tO\nor\tO\na\tO\nchange\tO\nof\tO\n2\tO\nor\tO\nmore\tO\nin\tO\nthe\tO\npatient\tT-0\n-\tT-0\nreported\tT-0\nakathisia\tB-Disease\nrating\tO\nscale\tO\nand\tO\na\tO\nchange\tO\nof\tO\nat\tO\nleast\tO\n1\tO\nin\tO\nthe\tO\ninvestigator\tO\n-\tO\nobserved\tO\nakathisia\tO\nrating\tO\nscale\tO\n.\tO\n\nAkathisia\tO\nwas\tO\ndefined\tO\nas\tO\neither\tO\na\tO\nspontaneous\tO\nreport\tO\nof\tO\nrestlessness\tO\nor\tO\nagitation\tO\nor\tO\na\tO\nchange\tO\nof\tO\n2\tO\nor\tO\nmore\tO\nin\tO\nthe\tO\npatient\tO\n-\tO\nreported\tO\nakathisia\tO\nrating\tO\nscale\tO\nand\tO\na\tO\nchange\tO\nof\tO\nat\tO\nleast\tO\n1\tO\nin\tO\nthe\tO\ninvestigator\tO\n-\tO\nobserved\tT-0\nakathisia\tB-Disease\nrating\tT-1\nscale\tT-1\n.\tO\n\nThe\tO\nintensity\tT-1\nof\tT-1\nheadache\tB-Disease\nand\tO\nnausea\tT-0\nwas\tO\nmeasured\tO\nwith\tO\na\tO\n100\tO\n-\tO\nmm\tO\nvisual\tO\nanalog\tO\nscale\tO\n.\tO\n\nThe\tO\nintensity\tO\nof\tO\nheadache\tO\nand\tO\nnausea\tB-Disease\nwas\tO\nmeasured\tT-0\nwith\tT-0\na\tO\n100\tO\n-\tO\nmm\tO\nvisual\tO\nanalog\tO\nscale\tO\n.\tO\n\nSeventy\tO\n-\tO\nthree\tO\npercent\tO\n(\tO\n73\tO\n/\tO\n99\tO\n)\tO\nof\tO\nthe\tO\nstudy\tO\nparticipants\tO\nwere\tO\ntreated\tT-1\nfor\tT-1\nheadache\tB-Disease\nand\tT-0\n70\tT-0\n%\tT-0\n(\tO\n70\tO\n/\tO\n99\tO\n)\tO\nfor\tO\nnausea\tO\n.\tO\n\nSeventy\tO\n-\tO\nthree\tO\npercent\tO\n(\tO\n73\tO\n/\tO\n99\tO\n)\tO\nof\tO\nthe\tO\nstudy\tO\nparticipants\tO\nwere\tO\ntreated\tO\nfor\tO\nheadache\tO\nand\tO\n70\tO\n%\tO\n(\tO\n70\tO\n/\tO\n99\tO\n)\tO\nfor\tT-0\nnausea\tB-Disease\n.\tO\n\nIn\tO\nthe\tO\nbolus\tO\ngroup\tT-0\n,\tO\n26\tO\n.\tO\n0\tO\n%\tO\n(\tO\n13\tO\n/\tO\n50\tO\n)\tO\nhad\tT-1\nakathisia\tB-Disease\ncompared\tO\nwith\tO\n32\tO\n.\tO\n7\tO\n%\tO\n(\tO\n16\tO\n/\tO\n49\tO\n)\tO\nin\tO\nthe\tO\ninfusion\tO\ngroup\tO\n(\tO\nDelta\tO\n=\tO\n-\tO\n6\tO\n.\tO\n7\tO\n%\tO\n;\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n[\tO\nCI\tO\n]\tO\n-\tO\n24\tO\n.\tO\n6\tO\n%\tO\nto\tO\n11\tO\n.\tO\n2\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\ndifference\tO\nbetween\tO\nthe\tO\nbolus\tO\nand\tO\ninfusion\tO\ngroups\tO\nin\tO\nthe\tO\npercentage\tO\nof\tO\nparticipants\tO\nwho\tO\nsaw\tO\na\tO\n50\tO\n%\tO\nreduction\tT-0\nin\tT-0\ntheir\tT-0\nheadache\tB-Disease\nintensity\tT-1\nwithin\tO\n30\tO\nminutes\tO\nwas\tO\n11\tO\n.\tO\n8\tO\n%\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n-\tO\n9\tO\n.\tO\n6\tO\n%\tO\nto\tO\n33\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\ndifference\tO\nin\tO\nthe\tO\npercentage\tO\nof\tO\npatients\tO\nwith\tO\na\tO\n50\tO\n%\tO\nreduction\tT-0\nin\tT-0\ntheir\tT-0\nnausea\tB-Disease\nwas\tT-1\n12\tT-1\n.\tT-1\n6\tT-1\n%\tT-1\n(\tO\n95\tO\n%\tO\nCI\tO\n-\tO\n4\tO\n.\tO\n6\tO\n%\tO\nto\tO\n29\tO\n.\tO\n8\tO\n%\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nA\tO\n50\tO\n%\tO\nreduction\tT-1\nin\tT-1\nthe\tT-1\nincidence\tT-1\nof\tT-1\nakathisia\tB-Disease\nwhen\tO\nprochlorperazine\tO\nwas\tO\nadministered\tT-0\nby\tO\nmeans\tO\nof\tO\n15\tO\n-\tO\nminute\tO\nintravenous\tO\ninfusion\tO\nversus\tO\na\tO\n2\tO\n-\tO\nminute\tO\nintravenous\tO\npush\tO\nwas\tO\nnot\tO\ndetected\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nA\tO\n50\tO\n%\tO\nreduction\tO\nin\tO\nthe\tO\nincidence\tO\nof\tO\nakathisia\tO\nwhen\tO\nprochlorperazine\tB-Chemical\nwas\tO\nadministered\tT-0\nby\tO\nmeans\tO\nof\tO\n15\tO\n-\tO\nminute\tO\nintravenous\tT-1\ninfusion\tT-1\nversus\tO\na\tO\n2\tO\n-\tO\nminute\tO\nintravenous\tO\npush\tO\nwas\tO\nnot\tO\ndetected\tO\n.\tO\n\nThe\tO\nefficacy\tT-0\nof\tT-0\nprochlorperazine\tB-Chemical\nin\tO\nthe\tO\ntreatment\tT-1\nof\tT-1\nheadache\tO\nand\tO\nnausea\tO\nlikewise\tO\ndid\tO\nnot\tO\nappear\tO\nto\tO\nbe\tO\naffected\tO\nby\tO\nthe\tO\nrate\tO\nof\tO\nadministration\tO\n,\tO\nalthough\tO\nno\tO\nformal\tO\nstatistical\tO\ncomparisons\tO\nwere\tO\nmade\tO\n.\tO\n\nThe\tO\nefficacy\tO\nof\tO\nprochlorperazine\tO\nin\tO\nthe\tO\ntreatment\tT-1\nof\tT-1\nheadache\tB-Disease\nand\tT-2\nnausea\tT-2\nlikewise\tO\ndid\tO\nnot\tO\nappear\tO\nto\tO\nbe\tO\naffected\tO\nby\tO\nthe\tO\nrate\tO\nof\tO\nadministration\tO\n,\tO\nalthough\tO\nno\tO\nformal\tO\nstatistical\tO\ncomparisons\tO\nwere\tO\nmade\tO\n.\tO\n\nThe\tO\nefficacy\tO\nof\tO\nprochlorperazine\tO\nin\tO\nthe\tO\ntreatment\tT-1\nof\tT-1\nheadache\tO\nand\tO\nnausea\tB-Disease\nlikewise\tO\ndid\tO\nnot\tO\nappear\tO\nto\tO\nbe\tO\naffected\tO\nby\tO\nthe\tO\nrate\tO\nof\tO\nadministration\tO\n,\tO\nalthough\tO\nno\tO\nformal\tO\nstatistical\tO\ncomparisons\tO\nwere\tO\nmade\tO\n.\tO\n\nCombined\tO\nantiretroviral\tO\ntherapy\tT-0\ncauses\tT-1\ncardiomyopathy\tB-Disease\nand\tO\nelevates\tT-2\nplasma\tO\nlactate\tO\nin\tO\ntransgenic\tO\nAIDS\tO\nmice\tO\n.\tO\n\nCombined\tO\nantiretroviral\tT-0\ntherapy\tT-0\ncauses\tO\ncardiomyopathy\tO\nand\tO\nelevates\tO\nplasma\tO\nlactate\tB-Chemical\nin\tO\ntransgenic\tO\nAIDS\tO\nmice\tO\n.\tO\n\nCombined\tO\nantiretroviral\tO\ntherapy\tO\ncauses\tO\ncardiomyopathy\tO\nand\tO\nelevates\tT-2\nplasma\tO\nlactate\tO\nin\tO\ntransgenic\tT-0\nAIDS\tB-Disease\nmice\tT-1\n.\tO\n\nHighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nis\tO\nimplicated\tT-1\nin\tT-1\ncardiomyopathy\tB-Disease\n(\tT-2\nCM\tT-2\n)\tT-2\nand\tT-0\nin\tT-0\nelevated\tT-0\nplasma\tT-0\nlactate\tT-0\n(\tO\nLA\tO\n)\tO\nin\tO\nAIDS\tO\nthrough\tO\nmechanisms\tO\nof\tO\nmitochondrial\tO\ndysfunction\tO\n.\tO\n\nHighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nis\tO\nimplicated\tT-0\nin\tO\ncardiomyopathy\tO\n(\tO\nCM\tB-Disease\n)\tO\nand\tO\nin\tO\nelevated\tO\nplasma\tO\nlactate\tO\n(\tO\nLA\tO\n)\tO\nin\tO\nAIDS\tO\nthrough\tO\nmechanisms\tO\nof\tO\nmitochondrial\tO\ndysfunction\tO\n.\tO\n\nHighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nis\tO\nimplicated\tO\nin\tO\ncardiomyopathy\tO\n(\tO\nCM\tO\n)\tO\nand\tO\nin\tO\nelevated\tT-1\nplasma\tO\nlactate\tB-Chemical\n(\tO\nLA\tO\n)\tO\nin\tT-0\nAIDS\tT-0\nthrough\tO\nmechanisms\tO\nof\tO\nmitochondrial\tO\ndysfunction\tO\n.\tO\n\nHighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nis\tO\nimplicated\tO\nin\tO\ncardiomyopathy\tO\n(\tO\nCM\tO\n)\tO\nand\tO\nin\tO\nelevated\tT-1\nplasma\tT-0\nlactate\tT-0\n(\tO\nLA\tB-Chemical\n)\tO\nin\tO\nAIDS\tO\nthrough\tO\nmechanisms\tO\nof\tO\nmitochondrial\tO\ndysfunction\tO\n.\tO\n\nHighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nis\tO\nimplicated\tO\nin\tO\ncardiomyopathy\tO\n(\tO\nCM\tO\n)\tO\nand\tO\nin\tO\nelevated\tT-0\nplasma\tO\nlactate\tO\n(\tO\nLA\tO\n)\tO\nin\tO\nAIDS\tB-Disease\nthrough\tO\nmechanisms\tO\nof\tO\nmitochondrial\tO\ndysfunction\tO\n.\tO\n\nHighly\tO\nactive\tO\nantiretroviral\tO\ntherapy\tO\n(\tO\nHAART\tO\n)\tO\nis\tO\nimplicated\tO\nin\tO\ncardiomyopathy\tO\n(\tO\nCM\tO\n)\tO\nand\tO\nin\tO\nelevated\tO\nplasma\tO\nlactate\tO\n(\tO\nLA\tO\n)\tO\nin\tO\nAIDS\tO\nthrough\tO\nmechanisms\tT-0\nof\tT-0\nmitochondrial\tB-Disease\ndysfunction\tI-Disease\n.\tO\n\nTo\tO\ndetermine\tO\nmitochondrial\tO\nevents\tO\nfrom\tO\nHAART\tO\nin\tO\nvivo\tO\n,\tO\n8\tO\n-\tO\nweek\tO\n-\tO\nold\tO\nhemizygous\tO\ntransgenic\tT-1\nAIDS\tB-Disease\nmice\tO\n(\tO\nNL4\tO\n-\tO\n3Delta\tO\ngag\tO\n/\tO\npol\tO\n;\tO\nTG\tO\n)\tO\nand\tO\nwild\tO\n-\tO\ntype\tO\nFVB\tO\n/\tO\nn\tO\nlittermates\tT-0\nwere\tT-0\ntreated\tT-0\nwith\tO\nthe\tO\nHAART\tO\ncombination\tO\nof\tO\nzidovudine\tO\n,\tO\nlamivudine\tO\n,\tO\nand\tO\nindinavir\tO\nor\tO\nvehicle\tO\ncontrol\tO\nfor\tO\n10\tO\ndays\tO\nor\tO\n35\tO\ndays\tO\n.\tO\n\nTo\tO\ndetermine\tO\nmitochondrial\tO\nevents\tO\nfrom\tO\nHAART\tO\nin\tO\nvivo\tO\n,\tO\n8\tO\n-\tO\nweek\tO\n-\tO\nold\tO\nhemizygous\tO\ntransgenic\tO\nAIDS\tO\nmice\tO\n(\tO\nNL4\tO\n-\tO\n3Delta\tO\ngag\tO\n/\tO\npol\tO\n;\tO\nTG\tO\n)\tO\nand\tO\nwild\tO\n-\tO\ntype\tO\nFVB\tO\n/\tO\nn\tO\nlittermates\tO\nwere\tO\ntreated\tO\nwith\tO\nthe\tO\nHAART\tO\ncombination\tT-1\nof\tT-1\nzidovudine\tB-Chemical\n,\tO\nlamivudine\tT-0\n,\tO\nand\tO\nindinavir\tO\nor\tO\nvehicle\tO\ncontrol\tO\nfor\tO\n10\tO\ndays\tO\nor\tO\n35\tO\ndays\tO\n.\tO\n\nTo\tO\ndetermine\tO\nmitochondrial\tO\nevents\tO\nfrom\tO\nHAART\tO\nin\tO\nvivo\tO\n,\tO\n8\tO\n-\tO\nweek\tO\n-\tO\nold\tO\nhemizygous\tO\ntransgenic\tO\nAIDS\tO\nmice\tO\n(\tO\nNL4\tO\n-\tO\n3Delta\tO\ngag\tO\n/\tO\npol\tO\n;\tO\nTG\tO\n)\tO\nand\tO\nwild\tO\n-\tO\ntype\tO\nFVB\tO\n/\tO\nn\tO\nlittermates\tO\nwere\tO\ntreated\tT-0\nwith\tT-0\nthe\tO\nHAART\tO\ncombination\tO\nof\tO\nzidovudine\tO\n,\tO\nlamivudine\tO\n,\tO\nand\tO\nindinavir\tB-Chemical\nor\tO\nvehicle\tT-1\ncontrol\tT-1\nfor\tT-1\n10\tT-1\ndays\tT-1\nor\tT-1\n35\tT-1\ndays\tT-1\n.\tO\n\nAt\tO\ntermination\tO\nof\tO\nthe\tO\nexperiments\tO\n,\tO\nmice\tO\nunderwent\tO\nechocardiography\tO\n,\tO\nquantitation\tO\nof\tO\nabundance\tO\nof\tO\nmolecular\tT-0\nmarkers\tT-0\nof\tT-0\nCM\tB-Disease\n(\tO\nventricular\tO\nmRNA\tO\nencoding\tO\natrial\tO\nnatriuretic\tO\nfactor\tO\n[\tO\nANF\tO\n]\tO\nand\tO\nsarcoplasmic\tO\ncalcium\tO\nATPase\tO\n[\tO\nSERCA2\tO\n]\tO\n)\tO\n,\tO\nand\tO\ndetermination\tO\nof\tO\nplasma\tO\nLA\tO\n.\tO\n\nAt\tO\ntermination\tO\nof\tO\nthe\tO\nexperiments\tO\n,\tO\nmice\tO\nunderwent\tO\nechocardiography\tO\n,\tO\nquantitation\tO\nof\tO\nabundance\tO\nof\tO\nmolecular\tO\nmarkers\tO\nof\tO\nCM\tO\n(\tO\nventricular\tO\nmRNA\tO\nencoding\tO\natrial\tO\nnatriuretic\tO\nfactor\tO\n[\tO\nANF\tO\n]\tO\nand\tO\nsarcoplasmic\tT-0\ncalcium\tB-Chemical\nATPase\tO\n[\tO\nSERCA2\tO\n]\tO\n)\tO\n,\tO\nand\tO\ndetermination\tT-1\nof\tT-1\nplasma\tT-1\nLA\tT-1\n.\tO\n\nAt\tO\ntermination\tO\nof\tO\nthe\tO\nexperiments\tO\n,\tO\nmice\tO\nunderwent\tO\nechocardiography\tO\n,\tO\nquantitation\tO\nof\tO\nabundance\tO\nof\tO\nmolecular\tO\nmarkers\tO\nof\tO\nCM\tO\n(\tO\nventricular\tO\nmRNA\tO\nencoding\tO\natrial\tO\nnatriuretic\tO\nfactor\tO\n[\tO\nANF\tO\n]\tO\nand\tO\nsarcoplasmic\tO\ncalcium\tO\nATPase\tO\n[\tO\nSERCA2\tO\n]\tO\n)\tO\n,\tO\nand\tO\ndetermination\tT-0\nof\tT-0\nplasma\tT-0\nLA\tB-Chemical\n.\tO\n\nBiochemically\tT-0\n,\tO\nLA\tB-Chemical\nwas\tT-1\nelevated\tT-1\n(\tO\n8\tO\n.\tO\n5\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n0\tO\nmM\tO\n)\tO\n.\tO\n\nResults\tT-2\nshow\tT-2\nthat\tO\ncumulative\tO\nHAART\tO\ncaused\tT-0\nmitochondrial\tO\nCM\tB-Disease\nwith\tT-1\nelevated\tT-1\nLA\tO\nin\tO\nAIDS\tO\ntransgenic\tO\nmice\tO\n.\tO\n\nResults\tO\nshow\tO\nthat\tO\ncumulative\tO\nHAART\tO\ncaused\tT-0\nmitochondrial\tO\nCM\tO\nwith\tO\nelevated\tT-1\nLA\tB-Chemical\nin\tO\nAIDS\tO\ntransgenic\tO\nmice\tO\n.\tO\n\nResults\tT-0\nshow\tO\nthat\tO\ncumulative\tO\nHAART\tO\ncaused\tO\nmitochondrial\tO\nCM\tO\nwith\tO\nelevated\tT-1\nLA\tT-1\nin\tT-1\nAIDS\tB-Disease\ntransgenic\tO\nmice\tO\n.\tO\n\nA\tO\nPhase\tO\nII\tO\ntrial\tT-2\nof\tT-2\ncisplatin\tB-Chemical\nplus\tT-0\nWR\tT-0\n-\tT-0\n2721\tT-0\n(\tO\namifostine\tO\n)\tO\nfor\tT-1\nmetastatic\tT-1\nbreast\tT-1\ncarcinoma\tT-1\n:\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nStudy\tO\n(\tO\nE8188\tO\n)\tO\n.\tO\n\nA\tO\nPhase\tT-0\nII\tT-0\ntrial\tT-0\nof\tO\ncisplatin\tO\nplus\tO\nWR\tB-Chemical\n-\tI-Chemical\n2721\tI-Chemical\n(\tO\namifostine\tO\n)\tO\nfor\tO\nmetastatic\tO\nbreast\tO\ncarcinoma\tO\n:\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nStudy\tO\n(\tO\nE8188\tO\n)\tO\n.\tO\n\nA\tT-1\nPhase\tT-1\nII\tT-1\ntrial\tT-1\nof\tT-1\ncisplatin\tO\nplus\tO\nWR\tO\n-\tO\n2721\tO\n(\tO\namifostine\tB-Chemical\n)\tO\nfor\tT-0\nmetastatic\tT-0\nbreast\tO\ncarcinoma\tO\n:\tO\nan\tO\nEastern\tO\nCooperative\tO\nOncology\tO\nGroup\tO\nStudy\tO\n(\tO\nE8188\tO\n)\tO\n.\tO\n\nA\tO\nPhase\tO\nII\tO\ntrial\tO\nof\tO\ncisplatin\tO\nplus\tO\nWR\tO\n-\tO\n2721\tO\n(\tO\namifostine\tO\n)\tO\nfor\tO\nmetastatic\tT-1\nbreast\tB-Disease\ncarcinoma\tI-Disease\n:\tO\nan\tO\nEastern\tT-0\nCooperative\tT-0\nOncology\tT-0\nGroup\tT-0\nStudy\tT-0\n(\tO\nE8188\tO\n)\tO\n.\tO\n\nBACKGROUND\tT-0\n:\tO\nCisplatin\tB-Chemical\nhas\tT-1\nminimal\tT-1\nantitumor\tT-1\nactivity\tT-1\nwhen\tO\nused\tO\nas\tO\nsecond\tO\n-\tO\nor\tO\nthird\tO\n-\tO\nline\tO\ntreatment\tO\nof\tO\nmetastatic\tO\nbreast\tO\ncarcinoma\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCisplatin\tO\nhas\tO\nminimal\tO\nantitumor\tO\nactivity\tO\nwhen\tO\nused\tO\nas\tO\nsecond\tO\n-\tO\nor\tO\nthird\tO\n-\tO\nline\tO\ntreatment\tT-0\nof\tT-0\nmetastatic\tT-0\nbreast\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nOlder\tO\nreports\tO\nsuggest\tO\nan\tO\nobjective\tO\nresponse\tT-0\nrate\tT-0\nof\tT-0\n8\tO\n%\tO\nwhen\tO\n60\tO\n-\tO\n120\tO\nmg\tO\n/\tO\nm2\tO\nof\tO\ncisplatin\tB-Chemical\nis\tO\nadministered\tT-1\nevery\tO\n3\tO\n-\tO\n4\tO\nweeks\tO\n.\tO\n\nAlthough\tO\na\tO\ndose\tT-3\n-\tT-3\nresponse\tT-3\neffect\tT-3\nhas\tT-1\nbeen\tT-1\nobserved\tT-1\nwith\tT-1\ncisplatin\tB-Chemical\n,\tO\nthe\tT-2\ndose\tT-2\n-\tO\nlimiting\tO\ntoxicities\tO\nassociated\tO\nwith\tO\ncisplatin\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneurotoxicity\tO\n)\tO\nhave\tO\nlimited\tO\nits\tO\nuse\tO\nas\tO\na\tO\ntreatment\tO\nfor\tO\nbreast\tO\ncarcinoma\tO\n.\tO\n\nAlthough\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\neffect\tO\nhas\tO\nbeen\tO\nobserved\tO\nwith\tO\ncisplatin\tO\n,\tO\nthe\tT-0\ndose\tT-1\n-\tT-1\nlimiting\tT-1\ntoxicities\tB-Disease\nassociated\tT-2\nwith\tO\ncisplatin\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneurotoxicity\tO\n)\tO\nhave\tO\nlimited\tO\nits\tO\nuse\tO\nas\tO\na\tO\ntreatment\tO\nfor\tO\nbreast\tO\ncarcinoma\tO\n.\tO\n\nAlthough\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\neffect\tO\nhas\tO\nbeen\tO\nobserved\tO\nwith\tO\ncisplatin\tO\n,\tO\nthe\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicities\tO\nassociated\tT-0\nwith\tT-0\ncisplatin\tB-Chemical\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneurotoxicity\tO\n)\tO\nhave\tO\nlimited\tO\nits\tO\nuse\tO\nas\tO\na\tO\ntreatment\tO\nfor\tO\nbreast\tO\ncarcinoma\tO\n.\tO\n\nAlthough\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\neffect\tO\nhas\tO\nbeen\tO\nobserved\tO\nwith\tO\ncisplatin\tO\n,\tO\nthe\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicities\tO\nassociated\tT-2\nwith\tT-2\ncisplatin\tT-0\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nnephrotoxicity\tB-Disease\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneurotoxicity\tO\n)\tO\nhave\tT-1\nlimited\tT-1\nits\tO\nuse\tO\nas\tO\na\tO\ntreatment\tO\nfor\tO\nbreast\tO\ncarcinoma\tO\n.\tO\n\nAlthough\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\neffect\tO\nhas\tO\nbeen\tO\nobserved\tO\nwith\tO\ncisplatin\tO\n,\tO\nthe\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicities\tO\nassociated\tO\nwith\tO\ncisplatin\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tB-Disease\n,\tO\nand\tO\nneurotoxicity\tO\n)\tO\nhave\tO\nlimited\tO\nits\tO\nuse\tO\nas\tO\na\tO\ntreatment\tT-0\nfor\tO\nbreast\tO\ncarcinoma\tO\n.\tO\n\nAlthough\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\neffect\tO\nhas\tO\nbeen\tO\nobserved\tO\nwith\tO\ncisplatin\tO\n,\tO\nthe\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicities\tO\nassociated\tT-1\nwith\tT-1\ncisplatin\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneurotoxicity\tB-Disease\n)\tO\nhave\tT-0\nlimited\tT-0\nits\tO\nuse\tO\nas\tO\na\tO\ntreatment\tO\nfor\tO\nbreast\tO\ncarcinoma\tO\n.\tO\n\nAlthough\tO\na\tO\ndose\tO\n-\tO\nresponse\tO\neffect\tO\nhas\tO\nbeen\tO\nobserved\tO\nwith\tO\ncisplatin\tO\n,\tO\nthe\tO\ndose\tO\n-\tO\nlimiting\tO\ntoxicities\tO\nassociated\tO\nwith\tO\ncisplatin\tO\n(\tO\ne\tO\n.\tO\ng\tO\n.\tO\n,\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneurotoxicity\tO\n)\tO\nhave\tO\nlimited\tO\nits\tO\nuse\tO\nas\tO\na\tO\ntreatment\tT-1\nfor\tT-1\nbreast\tB-Disease\ncarcinoma\tI-Disease\n.\tO\n\nWR\tB-Chemical\n-\tI-Chemical\n2721\tI-Chemical\nor\tT-0\namifostine\tO\ninitially\tO\nwas\tT-1\ndeveloped\tT-1\nto\tO\nprotect\tO\nmilitary\tO\npersonnel\tO\nin\tO\nthe\tO\nevent\tO\nof\tO\nnuclear\tO\nwar\tO\n.\tO\n\nWR\tO\n-\tO\n2721\tO\nor\tO\namifostine\tB-Chemical\ninitially\tT-1\nwas\tT-1\ndeveloped\tT-1\nto\tO\nprotect\tO\nmilitary\tO\npersonnel\tO\nin\tO\nthe\tO\nevent\tO\nof\tO\nnuclear\tO\nwar\tO\n.\tO\n\nAmifostine\tB-Chemical\nsubsequently\tO\nwas\tT-1\nshown\tT-1\nto\tT-1\nprotect\tT-1\nnormal\tT-1\ntissues\tT-1\nfrom\tO\nthe\tO\ntoxic\tO\neffects\tO\nof\tO\nalkylating\tT-0\nagents\tT-0\nand\tO\ncisplatin\tO\nwithout\tO\ndecreasing\tO\nthe\tO\nantitumor\tO\neffect\tO\nof\tO\nthe\tO\nchemotherapy\tO\n.\tO\n\nAmifostine\tO\nsubsequently\tO\nwas\tO\nshown\tO\nto\tO\nprotect\tO\nnormal\tO\ntissues\tO\nfrom\tO\nthe\tO\ntoxic\tT-0\neffects\tT-1\nof\tT-1\nalkylating\tB-Chemical\nagents\tI-Chemical\nand\tO\ncisplatin\tO\nwithout\tO\ndecreasing\tO\nthe\tO\nantitumor\tO\neffect\tO\nof\tO\nthe\tO\nchemotherapy\tO\n.\tO\n\nAmifostine\tO\nsubsequently\tO\nwas\tO\nshown\tO\nto\tO\nprotect\tO\nnormal\tO\ntissues\tO\nfrom\tO\nthe\tO\ntoxic\tO\neffects\tO\nof\tO\nalkylating\tO\nagents\tO\nand\tO\ncisplatin\tB-Chemical\nwithout\tO\ndecreasing\tO\nthe\tO\nantitumor\tO\neffect\tT-0\nof\tT-0\nthe\tT-0\nchemotherapy\tO\n.\tO\n\nEarly\tO\ntrials\tT-0\nof\tT-0\ncisplatin\tB-Chemical\nand\tO\namifostine\tO\nalso\tO\nsuggested\tO\nthat\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\ncisplatin\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneuropathy\tO\nwere\tO\nreduced\tO\n.\tO\n\nEarly\tO\ntrials\tO\nof\tO\ncisplatin\tT-0\nand\tT-0\namifostine\tB-Chemical\nalso\tT-1\nsuggested\tT-1\nthat\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\ncisplatin\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneuropathy\tO\nwere\tO\nreduced\tO\n.\tO\n\nEarly\tO\ntrials\tO\nof\tO\ncisplatin\tO\nand\tO\namifostine\tO\nalso\tO\nsuggested\tO\nthat\tO\nthe\tO\nincidence\tT-2\nand\tT-2\nseverity\tT-2\nof\tT-2\ncisplatin\tB-Chemical\n-\tO\ninduced\tT-1\nnephrotoxicity\tT-1\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneuropathy\tO\nwere\tO\nreduced\tO\n.\tO\n\nEarly\tO\ntrials\tO\nof\tO\ncisplatin\tO\nand\tO\namifostine\tO\nalso\tO\nsuggested\tO\nthat\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\ncisplatin\tO\n-\tO\ninduced\tT-0\nnephrotoxicity\tB-Disease\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneuropathy\tO\nwere\tO\nreduced\tO\n.\tO\n\nEarly\tO\ntrials\tO\nof\tO\ncisplatin\tO\nand\tO\namifostine\tO\nalso\tO\nsuggested\tO\nthat\tO\nthe\tO\nincidence\tT-0\nand\tT-0\nseverity\tT-1\nof\tT-1\ncisplatin\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tB-Disease\n,\tO\nand\tO\nneuropathy\tO\nwere\tT-2\nreduced\tT-2\n.\tO\n\nEarly\tO\ntrials\tO\nof\tO\ncisplatin\tO\nand\tO\namifostine\tO\nalso\tO\nsuggested\tO\nthat\tO\nthe\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\ncisplatin\tO\n-\tO\ninduced\tO\nnephrotoxicity\tO\n,\tO\nototoxicity\tO\n,\tO\nand\tO\nneuropathy\tB-Disease\nwere\tT-0\nreduced\tT-1\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nPhase\tO\nII\tO\nstudy\tO\nof\tO\nthe\tO\ncombination\tT-2\nof\tT-2\ncisplatin\tB-Chemical\nplus\tT-1\namifostine\tO\nwas\tO\nconducted\tO\nin\tO\npatients\tO\nwith\tO\nprogressive\tO\nmetastatic\tO\nbreast\tO\ncarcinoma\tO\nwho\tO\nhad\tO\nreceived\tO\none\tO\n,\tO\nbut\tO\nnot\tO\nmore\tO\nthan\tO\none\tO\n,\tO\nchemotherapy\tO\nregimen\tO\nfor\tO\nmetastatic\tO\ndisease\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tO\nPhase\tO\nII\tO\nstudy\tO\nof\tO\nthe\tO\ncombination\tT-2\nof\tT-2\ncisplatin\tT-0\nplus\tT-0\namifostine\tB-Chemical\nwas\tT-1\nconducted\tT-1\nin\tT-1\npatients\tT-1\nwith\tO\nprogressive\tO\nmetastatic\tO\nbreast\tO\ncarcinoma\tO\nwho\tO\nhad\tO\nreceived\tO\none\tO\n,\tO\nbut\tO\nnot\tO\nmore\tO\nthan\tO\none\tO\n,\tO\nchemotherapy\tO\nregimen\tO\nfor\tO\nmetastatic\tO\ndisease\tO\n.\tO\n\nMETHODS\tO\n:\tO\nA\tT-0\nPhase\tT-0\nII\tT-0\nstudy\tT-2\nof\tO\nthe\tO\ncombination\tO\nof\tO\ncisplatin\tO\nplus\tO\namifostine\tO\nwas\tO\nconducted\tO\nin\tO\npatients\tT-3\nwith\tO\nprogressive\tO\nmetastatic\tT-1\nbreast\tB-Disease\ncarcinoma\tI-Disease\nwho\tO\nhad\tO\nreceived\tO\none\tO\n,\tO\nbut\tO\nnot\tO\nmore\tO\nthan\tO\none\tO\n,\tO\nchemotherapy\tO\nregimen\tO\nfor\tO\nmetastatic\tO\ndisease\tO\n.\tO\n\nPatients\tO\nreceived\tT-1\namifostine\tB-Chemical\n,\tO\n910\tO\nmg\tO\n/\tO\nm2\tO\nintravenously\tT-0\nover\tT-0\n15\tT-0\nminutes\tT-0\n.\tO\n\nAfter\tO\ncompletion\tT-1\nof\tT-1\nthe\tT-1\namifostine\tB-Chemical\ninfusion\tT-0\n,\tO\ncisplatin\tO\n120\tO\nmg\tO\n/\tO\nm2\tO\nwas\tO\nadministered\tO\nover\tO\n30\tO\nminutes\tO\n.\tO\n\nAfter\tO\ncompletion\tO\nof\tO\nthe\tO\namifostine\tO\ninfusion\tT-0\n,\tO\ncisplatin\tB-Chemical\n120\tO\nmg\tO\n/\tO\nm2\tO\nwas\tO\nadministered\tT-1\nover\tO\n30\tO\nminutes\tO\n.\tO\n\nIntravenous\tT-0\nhydration\tT-0\nand\tO\nmannitol\tB-Chemical\nwas\tO\nadministered\tT-1\nbefore\tT-1\nand\tT-1\nafter\tT-1\ncisplatin\tO\n.\tO\n\nIntravenous\tO\nhydration\tO\nand\tO\nmannitol\tO\nwas\tO\nadministered\tO\nbefore\tT-0\nand\tT-0\nafter\tT-0\ncisplatin\tB-Chemical\n.\tO\n\nNeurologic\tB-Disease\ntoxicity\tI-Disease\nwas\tO\nreported\tT-0\nin\tO\n52\tO\n%\tO\nof\tO\npatients\tT-1\n.\tO\n\nSeven\tO\ndifferent\tO\nlife\tT-0\n-\tT-0\nthreatening\tT-0\ntoxicities\tB-Disease\nwere\tO\nobserved\tO\nin\tO\npatients\tO\nwhile\tO\nreceiving\tT-1\ntreatment\tT-1\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tT-0\nof\tT-0\ncisplatin\tB-Chemical\nand\tT-1\namifostine\tO\nin\tO\nthis\tO\nstudy\tO\nresulted\tO\nin\tO\nan\tO\noverall\tO\nresponse\tO\nrate\tO\nof\tO\n16\tO\n%\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThe\tO\ncombination\tT-0\nof\tT-0\ncisplatin\tO\nand\tO\namifostine\tB-Chemical\nin\tO\nthis\tO\nstudy\tO\nresulted\tT-1\nin\tT-1\nan\tO\noverall\tO\nresponse\tO\nrate\tO\nof\tO\n16\tO\n%\tO\n.\tO\n\nNeither\tT-0\na\tT-0\ntumor\tB-Disease\n-\tO\nprotective\tO\neffect\tO\nnor\tO\nreduced\tO\ntoxicity\tO\nto\tO\nnormal\tO\ntissues\tO\nwas\tO\nobserved\tO\nwith\tO\nthe\tO\naddition\tO\nof\tO\namifostine\tO\nto\tO\ncisplatin\tO\nin\tO\nthis\tO\ntrial\tO\n.\tO\n\nNeither\tO\na\tO\ntumor\tO\n-\tO\nprotective\tO\neffect\tO\nnor\tO\nreduced\tT-2\ntoxicity\tB-Disease\nto\tT-1\nnormal\tO\ntissues\tO\nwas\tO\nobserved\tO\nwith\tO\nthe\tO\naddition\tO\nof\tO\namifostine\tO\nto\tO\ncisplatin\tO\nin\tO\nthis\tO\ntrial\tO\n.\tO\n\nNeither\tO\na\tO\ntumor\tO\n-\tO\nprotective\tO\neffect\tO\nnor\tO\nreduced\tO\ntoxicity\tO\nto\tO\nnormal\tO\ntissues\tO\nwas\tO\nobserved\tO\nwith\tO\nthe\tT-0\naddition\tT-0\nof\tT-0\namifostine\tB-Chemical\nto\tO\ncisplatin\tO\nin\tO\nthis\tO\ntrial\tO\n.\tO\n\nNeither\tO\na\tO\ntumor\tO\n-\tO\nprotective\tO\neffect\tO\nnor\tO\nreduced\tO\ntoxicity\tO\nto\tO\nnormal\tO\ntissues\tO\nwas\tO\nobserved\tT-1\nwith\tO\nthe\tO\naddition\tT-0\nof\tT-0\namifostine\tO\nto\tO\ncisplatin\tB-Chemical\nin\tO\nthis\tO\ntrial\tT-2\n.\tO\n\nOral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\nthe\tT-0\nrisk\tT-0\nof\tT-0\nmyocardial\tO\ninfarction\tO\n.\tO\n\nOral\tO\ncontraceptives\tO\nand\tO\nthe\tO\nrisk\tT-0\nof\tT-0\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nBACKGROUND\tO\n:\tO\nAn\tO\nassociation\tT-1\nbetween\tT-1\nthe\tT-1\nuse\tT-1\nof\tT-0\noral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\nthe\tO\nrisk\tO\nof\tO\nmyocardial\tO\ninfarction\tO\nhas\tO\nbeen\tO\nfound\tO\nin\tO\nsome\tO\n,\tO\nbut\tO\nnot\tO\nall\tO\n,\tO\nstudies\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthis\tO\nassociation\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\ntype\tT-2\nof\tT-2\nprogestagen\tB-Chemical\nincluded\tT-3\nin\tT-3\nthird\tT-3\n-\tT-3\ngeneration\tT-3\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\ndesogestrel\tO\nor\tO\ngestodene\tO\n)\tO\nand\tO\nsecond\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nlevonorgestrel\tO\n)\tO\noral\tO\ncontraceptives\tO\n,\tO\nthe\tO\ndose\tT-4\nof\tO\nestrogen\tO\n,\tO\nand\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nprothrombotic\tO\nmutations\tO\nMETHODS\tO\n:\tO\nIn\tO\na\tO\nnationwide\tO\n,\tO\npopulation\tO\n-\tO\nbased\tO\n,\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n,\tO\nwe\tO\nidentified\tO\nand\tO\nenrolled\tO\n248\tO\nwomen\tO\n18\tO\nthrough\tO\n49\tO\nyears\tO\nof\tO\nage\tO\nwho\tO\nhad\tO\nhad\tO\na\tO\nfirst\tO\nmyocardial\tO\ninfarction\tO\nbetween\tO\n1990\tO\nand\tO\n1995\tO\nand\tO\n925\tO\ncontrol\tO\nwomen\tO\nwho\tO\nhad\tO\nnot\tO\nhad\tO\na\tO\nmyocardial\tO\ninfarction\tO\nand\tO\nwho\tO\nwere\tO\nmatched\tO\nfor\tO\nage\tO\n,\tO\ncalendar\tO\nyear\tO\nof\tO\nthe\tO\nindex\tO\nevent\tO\n,\tO\nand\tO\narea\tO\nof\tO\nresidence\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthis\tO\nassociation\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\ntype\tO\nof\tO\nprogestagen\tO\nincluded\tO\nin\tO\nthird\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\ndesogestrel\tT-0\nor\tT-0\ngestodene\tB-Chemical\n)\tO\nand\tT-1\nsecond\tT-1\n-\tT-1\ngeneration\tT-1\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nlevonorgestrel\tO\n)\tO\noral\tO\ncontraceptives\tO\n,\tO\nthe\tO\ndose\tO\nof\tO\nestrogen\tO\n,\tO\nand\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nprothrombotic\tO\nmutations\tO\nMETHODS\tO\n:\tO\nIn\tO\na\tO\nnationwide\tO\n,\tO\npopulation\tO\n-\tO\nbased\tO\n,\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n,\tO\nwe\tO\nidentified\tO\nand\tO\nenrolled\tO\n248\tO\nwomen\tO\n18\tO\nthrough\tO\n49\tO\nyears\tO\nof\tO\nage\tO\nwho\tO\nhad\tO\nhad\tO\na\tO\nfirst\tO\nmyocardial\tO\ninfarction\tO\nbetween\tO\n1990\tO\nand\tO\n1995\tO\nand\tO\n925\tO\ncontrol\tO\nwomen\tO\nwho\tO\nhad\tO\nnot\tO\nhad\tO\na\tO\nmyocardial\tO\ninfarction\tO\nand\tO\nwho\tO\nwere\tO\nmatched\tO\nfor\tO\nage\tO\n,\tO\ncalendar\tO\nyear\tO\nof\tO\nthe\tO\nindex\tO\nevent\tO\n,\tO\nand\tO\narea\tO\nof\tO\nresidence\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthis\tO\nassociation\tO\n,\tO\naccording\tT-1\nto\tT-1\nthe\tO\ntype\tO\nof\tO\nprogestagen\tO\nincluded\tO\nin\tO\nthird\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\ndesogestrel\tO\nor\tO\ngestodene\tO\n)\tO\nand\tO\nsecond\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nlevonorgestrel\tB-Chemical\n)\tO\noral\tO\ncontraceptives\tO\n,\tO\nthe\tT-0\ndose\tT-0\nof\tT-0\nestrogen\tO\n,\tO\nand\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nprothrombotic\tO\nmutations\tO\nMETHODS\tO\n:\tO\nIn\tO\na\tO\nnationwide\tO\n,\tO\npopulation\tO\n-\tO\nbased\tO\n,\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n,\tO\nwe\tO\nidentified\tO\nand\tO\nenrolled\tO\n248\tO\nwomen\tO\n18\tO\nthrough\tO\n49\tO\nyears\tO\nof\tO\nage\tO\nwho\tO\nhad\tO\nhad\tO\na\tO\nfirst\tO\nmyocardial\tO\ninfarction\tO\nbetween\tO\n1990\tO\nand\tO\n1995\tO\nand\tO\n925\tO\ncontrol\tO\nwomen\tO\nwho\tO\nhad\tO\nnot\tO\nhad\tO\na\tO\nmyocardial\tO\ninfarction\tO\nand\tO\nwho\tO\nwere\tO\nmatched\tO\nfor\tO\nage\tO\n,\tO\ncalendar\tO\nyear\tO\nof\tO\nthe\tO\nindex\tO\nevent\tO\n,\tO\nand\tO\narea\tO\nof\tO\nresidence\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthis\tO\nassociation\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\ntype\tO\nof\tO\nprogestagen\tO\nincluded\tO\nin\tO\nthird\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\ndesogestrel\tO\nor\tO\ngestodene\tO\n)\tO\nand\tO\nsecond\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nlevonorgestrel\tO\n)\tO\noral\tO\ncontraceptives\tO\n,\tO\nthe\tO\ndose\tT-0\nof\tT-0\nestrogen\tB-Chemical\n,\tO\nand\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nprothrombotic\tO\nmutations\tO\nMETHODS\tO\n:\tO\nIn\tO\na\tO\nnationwide\tO\n,\tO\npopulation\tO\n-\tO\nbased\tO\n,\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n,\tO\nwe\tO\nidentified\tO\nand\tO\nenrolled\tO\n248\tO\nwomen\tO\n18\tO\nthrough\tO\n49\tO\nyears\tO\nof\tO\nage\tO\nwho\tO\nhad\tO\nhad\tO\na\tO\nfirst\tO\nmyocardial\tO\ninfarction\tO\nbetween\tO\n1990\tO\nand\tO\n1995\tO\nand\tO\n925\tO\ncontrol\tO\nwomen\tO\nwho\tO\nhad\tO\nnot\tO\nhad\tO\na\tO\nmyocardial\tO\ninfarction\tO\nand\tO\nwho\tO\nwere\tO\nmatched\tO\nfor\tO\nage\tO\n,\tO\ncalendar\tO\nyear\tO\nof\tO\nthe\tO\nindex\tO\nevent\tO\n,\tO\nand\tO\narea\tO\nof\tO\nresidence\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthis\tO\nassociation\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\ntype\tO\nof\tO\nprogestagen\tO\nincluded\tO\nin\tO\nthird\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\ndesogestrel\tO\nor\tO\ngestodene\tO\n)\tO\nand\tO\nsecond\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nlevonorgestrel\tO\n)\tO\noral\tO\ncontraceptives\tO\n,\tO\nthe\tO\ndose\tO\nof\tO\nestrogen\tO\n,\tO\nand\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nprothrombotic\tO\nmutations\tO\nMETHODS\tO\n:\tO\nIn\tO\na\tO\nnationwide\tO\n,\tO\npopulation\tO\n-\tO\nbased\tO\n,\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n,\tO\nwe\tO\nidentified\tO\nand\tO\nenrolled\tO\n248\tO\nwomen\tO\n18\tO\nthrough\tO\n49\tO\nyears\tO\nof\tO\nage\tO\nwho\tO\nhad\tO\nhad\tT-0\na\tT-0\nfirst\tT-0\nmyocardial\tB-Disease\ninfarction\tI-Disease\nbetween\tO\n1990\tO\nand\tO\n1995\tO\nand\tO\n925\tO\ncontrol\tO\nwomen\tO\nwho\tO\nhad\tO\nnot\tT-1\nhad\tT-1\na\tT-1\nmyocardial\tT-1\ninfarction\tT-1\nand\tO\nwho\tO\nwere\tO\nmatched\tO\nfor\tO\nage\tO\n,\tO\ncalendar\tO\nyear\tO\nof\tO\nthe\tO\nindex\tO\nevent\tO\n,\tO\nand\tO\narea\tO\nof\tO\nresidence\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthis\tO\nassociation\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\ntype\tO\nof\tO\nprogestagen\tO\nincluded\tO\nin\tO\nthird\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\ndesogestrel\tO\nor\tO\ngestodene\tO\n)\tO\nand\tO\nsecond\tO\n-\tO\ngeneration\tO\n(\tO\ni\tO\n.\tO\ne\tO\n.\tO\n,\tO\nlevonorgestrel\tO\n)\tO\noral\tO\ncontraceptives\tO\n,\tO\nthe\tO\ndose\tO\nof\tO\nestrogen\tO\n,\tO\nand\tO\nthe\tO\npresence\tO\nor\tO\nabsence\tO\nof\tO\nprothrombotic\tO\nmutations\tO\nMETHODS\tO\n:\tO\nIn\tO\na\tO\nnationwide\tO\n,\tO\npopulation\tO\n-\tO\nbased\tO\n,\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n,\tO\nwe\tO\nidentified\tO\nand\tO\nenrolled\tO\n248\tO\nwomen\tO\n18\tO\nthrough\tO\n49\tO\nyears\tO\nof\tO\nage\tO\nwho\tO\nhad\tO\nhad\tO\na\tO\nfirst\tO\nmyocardial\tO\ninfarction\tO\nbetween\tO\n1990\tO\nand\tO\n1995\tO\nand\tO\n925\tO\ncontrol\tO\nwomen\tO\nwho\tO\nhad\tO\nnot\tO\nhad\tT-1\na\tT-1\nmyocardial\tB-Disease\ninfarction\tI-Disease\nand\tO\nwho\tO\nwere\tT-0\nmatched\tT-0\nfor\tO\nage\tO\n,\tO\ncalendar\tO\nyear\tO\nof\tO\nthe\tO\nindex\tO\nevent\tO\n,\tO\nand\tO\narea\tO\nof\tO\nresidence\tO\n.\tO\n\nSubjects\tO\nsupplied\tO\ninformation\tT-0\non\tT-0\noral\tB-Chemical\n-\tI-Chemical\ncontraceptive\tI-Chemical\nuse\tT-2\nand\tT-2\nmajor\tT-2\ncardiovascular\tT-2\nrisk\tT-2\nfactors\tT-2\n.\tO\n\nAn\tO\nanalysis\tO\nfor\tO\nfactor\tO\nV\tO\nLeiden\tO\nand\tO\nthe\tO\nG20210A\tO\nmutation\tO\nin\tO\nthe\tO\nprothrombin\tO\ngene\tO\nwas\tO\nconducted\tO\nin\tO\n217\tO\npatients\tO\nand\tO\n763\tO\ncontrols\tO\nRESULTS\tO\n:\tO\nThe\tO\nodds\tO\nratio\tO\nfor\tO\nmyocardial\tO\ninfarction\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nany\tO\ntype\tO\nof\tT-0\ncombined\tT-0\noral\tB-Chemical\ncontraceptive\tI-Chemical\n,\tO\nas\tT-1\ncompared\tT-1\nwith\tT-1\nnonusers\tT-1\n,\tO\nwas\tO\n2\tO\n.\tO\n0\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n2\tO\n.\tO\n8\tO\n)\tO\n.\tO\n\nThe\tO\nadjusted\tO\nodds\tO\nratio\tO\nwas\tO\n2\tO\n.\tO\n5\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n4\tO\n.\tO\n1\tO\n)\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nsecond\tT-0\n-\tT-0\ngeneration\tT-0\noral\tB-Chemical\ncontraceptives\tI-Chemical\nand\tO\n1\tO\n.\tO\n3\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n7\tO\nto\tO\n2\tO\n.\tO\n5\tO\n)\tO\namong\tO\nthose\tO\nwho\tO\nused\tO\nthird\tT-1\n-\tT-1\ngeneration\tT-1\noral\tO\ncontraceptives\tO\n.\tO\n\nThe\tO\nadjusted\tO\nodds\tO\nratio\tT-1\nwas\tO\n2\tO\n.\tO\n5\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n4\tO\n.\tO\n1\tO\n)\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tO\ncontraceptives\tO\nand\tO\n1\tO\n.\tO\n3\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n7\tO\nto\tO\n2\tO\n.\tO\n5\tO\n)\tO\namong\tO\nthose\tO\nwho\tO\nused\tT-0\nthird\tT-2\n-\tT-2\ngeneration\tT-2\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nAmong\tO\nwomen\tO\nwho\tT-0\nused\tT-0\noral\tB-Chemical\ncontraceptives\tI-Chemical\n,\tO\nthe\tO\nodds\tO\nratio\tO\nwas\tO\n2\tO\n.\tO\n1\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n3\tO\n.\tO\n0\tO\n)\tO\nfor\tO\nthose\tO\nwithout\tO\na\tO\nprothrombotic\tO\nmutation\tO\nand\tO\n1\tO\n.\tO\n9\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n6\tO\nto\tO\n5\tO\n.\tO\n5\tO\n)\tO\nfor\tO\nthose\tO\nwith\tO\na\tO\nmutation\tO\nCONCLUSIONS\tO\n:\tO\nThe\tO\nrisk\tO\nof\tO\nmyocardial\tO\ninfarction\tO\nwas\tO\nincreased\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tO\ncontraceptives\tO\n.\tO\n\nAmong\tO\nwomen\tO\nwho\tO\nused\tO\noral\tO\ncontraceptives\tO\n,\tO\nthe\tO\nodds\tO\nratio\tO\nwas\tO\n2\tO\n.\tO\n1\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n3\tO\n.\tO\n0\tO\n)\tO\nfor\tO\nthose\tO\nwithout\tO\na\tO\nprothrombotic\tO\nmutation\tO\nand\tO\n1\tO\n.\tO\n9\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n6\tO\nto\tO\n5\tO\n.\tO\n5\tO\n)\tO\nfor\tO\nthose\tO\nwith\tO\na\tO\nmutation\tO\nCONCLUSIONS\tO\n:\tO\nThe\tO\nrisk\tT-0\nof\tT-0\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nincreased\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tO\ncontraceptives\tO\n.\tO\n\nAmong\tO\nwomen\tO\nwho\tO\nused\tO\noral\tT-0\ncontraceptives\tO\n,\tO\nthe\tO\nodds\tO\nratio\tO\nwas\tO\n2\tO\n.\tO\n1\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n1\tO\n.\tO\n5\tO\nto\tO\n3\tO\n.\tO\n0\tO\n)\tO\nfor\tO\nthose\tO\nwithout\tO\na\tO\nprothrombotic\tO\nmutation\tO\nand\tO\n1\tO\n.\tO\n9\tO\n(\tO\n95\tO\npercent\tO\nconfidence\tO\ninterval\tO\n,\tO\n0\tO\n.\tO\n6\tO\nto\tO\n5\tO\n.\tO\n5\tO\n)\tO\nfor\tO\nthose\tO\nwith\tO\na\tO\nmutation\tO\nCONCLUSIONS\tO\n:\tO\nThe\tO\nrisk\tO\nof\tO\nmyocardial\tO\ninfarction\tO\nwas\tO\nincreased\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tT-0\n\nThe\tO\nresults\tO\nwith\tO\nrespect\tT-1\nto\tT-1\nthe\tT-1\nuse\tT-1\nof\tT-1\nthird\tT-1\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\nwere\tT-0\ninconclusive\tT-0\nbut\tO\nsuggested\tO\nthat\tO\nthe\tO\nrisk\tO\nwas\tO\nlower\tO\nthan\tO\nthe\tO\nrisk\tO\nassociated\tO\nwith\tO\nsecond\tO\n-\tO\ngeneration\tO\noral\tO\ncontraceptives\tO\n.\tO\n\nThe\tO\nresults\tO\nwith\tO\nrespect\tO\nto\tO\nthe\tO\nuse\tO\nof\tO\nthird\tO\n-\tO\ngeneration\tO\noral\tO\ncontraceptives\tO\nwere\tO\ninconclusive\tO\nbut\tO\nsuggested\tO\nthat\tO\nthe\tO\nrisk\tO\nwas\tO\nlower\tO\nthan\tO\nthe\tO\nrisk\tO\nassociated\tT-0\nwith\tT-0\nsecond\tO\n-\tO\ngeneration\tO\noral\tB-Chemical\ncontraceptives\tI-Chemical\n.\tO\n\nThe\tO\nrisk\tT-1\nof\tT-1\nmyocardial\tB-Disease\ninfarction\tI-Disease\nwas\tO\nsimilar\tO\namong\tO\nwomen\tO\nwho\tO\nused\tO\noral\tO\ncontraceptives\tO\nwhether\tO\nor\tO\nnot\tO\nthey\tO\nhad\tO\na\tO\nprothrombotic\tT-0\nmutation\tT-0\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nmyocardial\tT-0\ninfarction\tT-0\nwas\tO\nsimilar\tO\namong\tO\nwomen\tO\nwho\tT-1\nused\tT-1\noral\tB-Chemical\ncontraceptives\tI-Chemical\nwhether\tT-2\nor\tT-2\nnot\tT-2\nthey\tT-2\nhad\tT-2\na\tO\nprothrombotic\tO\nmutation\tO\n.\tO\n\nEnd\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n(\tT-0\nESRD\tT-0\n)\tT-0\nafter\tO\northotopic\tO\nliver\tO\ntransplantation\tO\n(\tO\nOLTX\tO\n)\tO\nusing\tO\ncalcineurin\tO\n-\tO\nbased\tO\nimmunotherapy\tO\n:\tO\nrisk\tO\nof\tO\ndevelopment\tO\nand\tO\ntreatment\tO\n.\tO\n\nEnd\tO\n-\tO\nstage\tO\nrenal\tO\ndisease\tT-2\n(\tO\nESRD\tB-Disease\n)\tO\nafter\tT-3\northotopic\tT-3\nliver\tO\ntransplantation\tO\n(\tO\nOLTX\tO\n)\tO\nusing\tO\ncalcineurin\tO\n-\tO\nbased\tO\nimmunotherapy\tO\n:\tO\nrisk\tO\nof\tO\ndevelopment\tT-1\nand\tO\ntreatment\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\ncalcineurin\tT-1\ninhibitors\tT-1\ncyclosporine\tB-Chemical\nand\tO\ntacrolimus\tO\nare\tO\nboth\tO\nknown\tT-2\nto\tT-2\nbe\tT-2\nnephrotoxic\tT-2\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\ncalcineurin\tO\ninhibitors\tO\ncyclosporine\tO\nand\tO\ntacrolimus\tB-Chemical\nare\tO\nboth\tO\nknown\tO\nto\tO\nbe\tO\nnephrotoxic\tT-0\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\ncalcineurin\tT-0\ninhibitors\tT-0\ncyclosporine\tO\nand\tO\ntacrolimus\tO\nare\tO\nboth\tO\nknown\tT-1\nto\tT-1\nbe\tT-1\nnephrotoxic\tB-Disease\n.\tO\n\nRecently\tO\n,\tO\nhowever\tO\n,\tO\nwe\tO\nhave\tO\nhad\tO\nan\tO\nincrease\tO\nof\tO\npatients\tO\nwho\tO\nare\tO\npresenting\tO\nafter\tO\nOLTX\tT-0\nwith\tO\nend\tB-Disease\n-\tI-Disease\nstage\tI-Disease\nrenal\tI-Disease\ndisease\tI-Disease\n(\tO\nESRD\tT-1\n)\tT-1\n.\tT-1\n\nRecently\tO\n,\tO\nhowever\tO\n,\tO\nwe\tO\nhave\tO\nhad\tO\nan\tO\nincrease\tO\nof\tO\npatients\tT-2\nwho\tO\nare\tO\npresenting\tO\nafter\tO\nOLTX\tO\nwith\tO\nend\tT-1\n-\tT-1\nstage\tT-1\nrenal\tT-0\ndisease\tT-0\n(\tO\nESRD\tB-Disease\n)\tO\n.\tO\n\nThis\tO\nretrospective\tO\nstudy\tT-0\nexamines\tO\nthe\tO\nincidence\tT-1\nand\tO\ntreatment\tT-2\nof\tO\nESRD\tB-Disease\nand\tO\nchronic\tO\nrenal\tO\nfailure\tO\n(\tO\nCRF\tO\n)\tO\nin\tO\nOLTX\tO\npatients\tO\n.\tO\n\nThis\tO\nretrospective\tO\nstudy\tO\nexamines\tO\nthe\tO\nincidence\tT-0\nand\tT-0\ntreatment\tT-2\nof\tT-2\nESRD\tO\nand\tO\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n(\tO\nCRF\tO\n)\tO\nin\tT-3\nOLTX\tO\npatients\tT-1\n.\tO\n\nThis\tO\nretrospective\tO\nstudy\tO\nexamines\tO\nthe\tO\nincidence\tO\nand\tO\ntreatment\tT-1\nof\tT-1\nESRD\tO\nand\tT-0\nchronic\tT-0\nrenal\tT-0\nfailure\tT-0\n(\tO\nCRF\tB-Disease\n)\tO\nin\tT-2\nOLTX\tT-2\npatients\tT-2\n.\tO\n\nPatients\tO\nwere\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n:\tO\nControls\tO\n,\tO\nno\tO\nCRF\tB-Disease\nor\tO\nESRD\tT-0\n,\tT-0\nn\tT-0\n=\tT-0\n748\tT-0\n;\tO\nCRF\tO\n,\tO\nsustained\tO\nserum\tO\ncreatinine\tO\n>\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nn\tO\n=\tO\n41\tO\n;\tO\nand\tO\nESRD\tO\n,\tO\nn\tO\n=\tO\n45\tO\n.\tO\n\nPatients\tO\nwere\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n:\tO\nControls\tT-0\n,\tO\nno\tO\nCRF\tO\nor\tO\nESRD\tB-Disease\n,\tO\nn\tO\n=\tO\n748\tO\n;\tO\nCRF\tO\n,\tO\nsustained\tO\nserum\tO\ncreatinine\tO\n>\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nn\tO\n=\tO\n41\tO\n;\tO\nand\tO\nESRD\tO\n,\tO\nn\tO\n=\tO\n45\tO\n.\tO\n\nPatients\tO\nwere\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n:\tO\nControls\tT-0\n,\tO\nno\tO\nCRF\tO\nor\tO\nESRD\tO\n,\tO\nn\tO\n=\tO\n748\tO\n;\tO\nCRF\tB-Disease\n,\tO\nsustained\tO\nserum\tO\ncreatinine\tO\n>\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nn\tO\n=\tO\n41\tO\n;\tO\nand\tO\nESRD\tO\n,\tO\nn\tO\n=\tO\n45\tO\n.\tO\n\nPatients\tO\nwere\tO\ndivided\tO\ninto\tO\nthree\tO\ngroups\tO\n:\tO\nControls\tO\n,\tO\nno\tO\nCRF\tO\nor\tO\nESRD\tO\n,\tO\nn\tO\n=\tO\n748\tO\n;\tO\nCRF\tO\n,\tO\nsustained\tT-1\nserum\tO\ncreatinine\tB-Chemical\n>\tO\n2\tT-0\n.\tT-0\n5\tT-0\nmg\tT-0\n/\tT-0\ndl\tT-0\n,\tO\nn\tO\n=\tO\n41\tO\n;\tO\nand\tO\nESRD\tO\n,\tO\nn\tO\n=\tO\n45\tO\n.\tO\n\nPatients\tT-0\nwere\tT-0\ndivided\tT-0\ninto\tT-0\nthree\tO\ngroups\tT-1\n:\tO\nControls\tO\n,\tO\nno\tO\nCRF\tO\nor\tO\nESRD\tO\n,\tO\nn\tO\n=\tO\n748\tO\n;\tO\nCRF\tO\n,\tO\nsustained\tO\nserum\tO\ncreatinine\tO\n>\tO\n2\tO\n.\tO\n5\tO\nmg\tO\n/\tO\ndl\tO\n,\tO\nn\tT-2\n=\tT-2\n41\tT-2\n;\tT-2\nand\tT-2\nESRD\tB-Disease\n,\tO\nn\tT-3\n=\tT-3\n45\tT-3\n.\tO\n\nGroups\tO\nwere\tO\ncompared\tO\nfor\tO\npreoperative\tO\nlaboratory\tO\nvariables\tO\n,\tO\ndiagnosis\tO\n,\tO\npostoperative\tO\nvariables\tO\n,\tO\nsurvival\tO\n,\tO\ntype\tT-2\nof\tT-2\nESRD\tB-Disease\ntherapy\tT-0\n,\tO\nand\tO\nsurvival\tT-1\nfrom\tO\nonset\tO\nof\tO\nESRD\tO\n.\tO\n\nGroups\tO\nwere\tO\ncompared\tO\nfor\tO\npreoperative\tT-1\nlaboratory\tT-1\nvariables\tO\n,\tO\ndiagnosis\tO\n,\tO\npostoperative\tO\nvariables\tO\n,\tO\nsurvival\tO\n,\tO\ntype\tO\nof\tO\nESRD\tO\ntherapy\tO\n,\tO\nand\tO\nsurvival\tT-0\nfrom\tT-0\nonset\tT-0\nof\tO\nESRD\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nAt\tO\n13\tO\nyears\tO\nafter\tO\nOLTX\tO\n,\tO\nthe\tO\nincidence\tO\nof\tO\nsevere\tT-1\nrenal\tB-Disease\ndysfunction\tI-Disease\nwas\tT-2\n18\tT-0\n.\tT-0\n1\tT-0\n%\tT-0\n(\tT-0\nCRF\tT-0\n8\tT-0\n.\tT-0\n6\tT-0\n%\tT-0\nand\tT-0\nESRD\tT-0\n9\tT-0\n.\tT-0\n5\tT-0\n%\tT-0\n)\tT-0\n.\tT-0\n\nRESULTS\tO\n:\tO\nAt\tO\n13\tO\nyears\tO\nafter\tO\nOLTX\tO\n,\tO\nthe\tO\nincidence\tO\nof\tO\nsevere\tO\nrenal\tO\ndysfunction\tT-0\nwas\tT-1\n18\tT-1\n.\tT-1\n1\tT-1\n%\tT-1\n(\tO\nCRF\tB-Disease\n8\tT-2\n.\tT-2\n6\tT-2\n%\tT-2\nand\tO\nESRD\tO\n9\tO\n.\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nAt\tO\n13\tO\nyears\tO\nafter\tT-0\nOLTX\tT-0\n,\tO\nthe\tO\nincidence\tT-1\nof\tT-1\nsevere\tO\nrenal\tO\ndysfunction\tO\nwas\tO\n18\tO\n.\tO\n1\tO\n%\tO\n(\tO\nCRF\tO\n8\tO\n.\tO\n6\tO\n%\tO\nand\tO\nESRD\tB-Disease\n9\tO\n.\tO\n5\tO\n%\tO\n)\tO\n.\tO\n\nCompared\tO\nwith\tO\ncontrol\tO\npatients\tO\n,\tO\nCRF\tB-Disease\nand\tO\nESRD\tO\npatients\tO\nhad\tO\nhigher\tT-0\npreoperative\tT-0\nserum\tT-0\ncreatinine\tT-0\nlevels\tT-0\n,\tO\na\tO\ngreater\tO\npercentage\tO\nof\tO\npatients\tO\nwith\tO\nhepatorenal\tO\nsyndrome\tO\n,\tO\nhigher\tO\npercentage\tO\nrequirement\tO\nfor\tO\ndialysis\tO\nin\tO\nthe\tO\nfirst\tO\n3\tO\nmonths\tO\npostoperatively\tO\n,\tO\nand\tO\na\tO\nhigher\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tO\n.\tO\n\nCompared\tT-2\nwith\tT-2\ncontrol\tT-0\npatients\tT-0\n,\tO\nCRF\tO\nand\tO\nESRD\tB-Disease\npatients\tO\nhad\tO\nhigher\tO\npreoperative\tO\nserum\tO\ncreatinine\tO\nlevels\tO\n,\tO\na\tO\ngreater\tO\npercentage\tO\nof\tO\npatients\tT-1\nwith\tT-1\nhepatorenal\tT-1\nsyndrome\tT-1\n,\tO\nhigher\tO\npercentage\tO\nrequirement\tO\nfor\tO\ndialysis\tO\nin\tO\nthe\tO\nfirst\tO\n3\tO\nmonths\tO\npostoperatively\tO\n,\tO\nand\tO\na\tO\nhigher\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tO\n.\tO\n\nCompared\tO\nwith\tO\ncontrol\tO\npatients\tO\n,\tO\nCRF\tO\nand\tO\nESRD\tO\npatients\tO\nhad\tO\nhigher\tO\npreoperative\tT-0\nserum\tT-2\ncreatinine\tB-Chemical\nlevels\tT-1\n,\tO\na\tO\ngreater\tO\npercentage\tO\nof\tO\npatients\tO\nwith\tO\nhepatorenal\tO\nsyndrome\tO\n,\tO\nhigher\tO\npercentage\tO\nrequirement\tO\nfor\tO\ndialysis\tO\nin\tO\nthe\tO\nfirst\tO\n3\tO\nmonths\tO\npostoperatively\tO\n,\tO\nand\tO\na\tO\nhigher\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tO\n.\tO\n\nCompared\tO\nwith\tO\ncontrol\tO\npatients\tO\n,\tO\nCRF\tO\nand\tO\nESRD\tO\npatients\tO\nhad\tO\nhigher\tO\npreoperative\tO\nserum\tO\ncreatinine\tO\nlevels\tO\n,\tO\na\tO\ngreater\tO\npercentage\tO\nof\tO\npatients\tT-1\nwith\tT-1\nhepatorenal\tB-Disease\nsyndrome\tI-Disease\n,\tO\nhigher\tT-2\npercentage\tT-2\nrequirement\tO\nfor\tO\ndialysis\tO\nin\tO\nthe\tO\nfirst\tO\n3\tO\nmonths\tO\npostoperatively\tO\n,\tO\nand\tO\na\tO\nhigher\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tO\n.\tO\n\nCompared\tO\nwith\tO\ncontrol\tO\npatients\tO\n,\tO\nCRF\tO\nand\tO\nESRD\tO\npatients\tO\nhad\tO\nhigher\tO\npreoperative\tO\nserum\tO\ncreatinine\tO\nlevels\tO\n,\tO\na\tO\ngreater\tO\npercentage\tO\nof\tO\npatients\tO\nwith\tO\nhepatorenal\tO\nsyndrome\tO\n,\tO\nhigher\tO\npercentage\tO\nrequirement\tO\nfor\tO\ndialysis\tO\nin\tO\nthe\tO\nfirst\tO\n3\tO\nmonths\tO\npostoperatively\tO\n,\tO\nand\tT-1\na\tT-1\nhigher\tT-1\n1\tT-0\n-\tT-0\nyear\tT-0\nserum\tT-0\ncreatinine\tB-Chemical\n.\tO\n\nMultivariate\tO\nstepwise\tO\nlogistic\tO\nregression\tO\nanalysis\tO\nusing\tO\npreoperative\tO\nand\tO\npostoperative\tO\nvariables\tO\nidentified\tO\nthat\tO\nan\tO\nincrease\tO\nof\tO\nserum\tT-0\ncreatinine\tB-Chemical\ncompared\tT-1\nwith\tT-1\naverage\tT-1\nat\tT-1\n1\tT-1\nyear\tT-1\n,\tO\n3\tO\nmonths\tO\n,\tO\nand\tO\n4\tO\nweeks\tO\npostoperatively\tO\nwere\tO\nindependent\tO\nrisk\tO\nfactors\tO\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nCRF\tO\nor\tO\nESRD\tO\nwith\tO\nodds\tO\nratios\tO\nof\tO\n2\tO\n.\tO\n6\tO\n,\tO\n2\tO\n.\tO\n2\tO\n,\tO\nand\tO\n1\tO\n.\tO\n6\tO\n,\tO\nrespectively\tO\n.\tO\n\nMultivariate\tO\nstepwise\tO\nlogistic\tO\nregression\tO\nanalysis\tO\nusing\tO\npreoperative\tO\nand\tO\npostoperative\tO\nvariables\tO\nidentified\tO\nthat\tO\nan\tO\nincrease\tO\nof\tO\nserum\tO\ncreatinine\tO\ncompared\tO\nwith\tO\naverage\tO\nat\tO\n1\tO\nyear\tO\n,\tO\n3\tO\nmonths\tO\n,\tO\nand\tO\n4\tO\nweeks\tO\npostoperatively\tO\nwere\tO\nindependent\tO\nrisk\tO\nfactors\tO\nfor\tO\nthe\tO\ndevelopment\tT-0\nof\tT-0\nCRF\tB-Disease\nor\tO\nESRD\tO\nwith\tO\nodds\tO\nratios\tO\nof\tO\n2\tO\n.\tO\n6\tO\n,\tO\n2\tO\n.\tO\n2\tO\n,\tO\nand\tO\n1\tO\n.\tO\n6\tO\n,\tO\nrespectively\tO\n.\tO\n\nMultivariate\tO\nstepwise\tO\nlogistic\tO\nregression\tO\nanalysis\tO\nusing\tO\npreoperative\tO\nand\tO\npostoperative\tO\nvariables\tO\nidentified\tO\nthat\tO\nan\tO\nincrease\tO\nof\tO\nserum\tO\ncreatinine\tO\ncompared\tO\nwith\tO\naverage\tO\nat\tO\n1\tO\nyear\tO\n,\tO\n3\tO\nmonths\tO\n,\tO\nand\tO\n4\tO\nweeks\tO\npostoperatively\tO\nwere\tO\nindependent\tO\nrisk\tO\nfactors\tO\nfor\tO\nthe\tO\ndevelopment\tT-0\nof\tT-0\nCRF\tO\nor\tO\nESRD\tB-Disease\nwith\tO\nodds\tO\nratios\tO\nof\tO\n2\tO\n.\tO\n6\tO\n,\tO\n2\tO\n.\tO\n2\tO\n,\tO\nand\tO\n1\tO\n.\tO\n6\tO\n,\tO\nrespectively\tO\n.\tO\n\nOverall\tO\nsurvival\tO\nfrom\tO\nthe\tO\ntime\tO\nof\tO\nOLTX\tO\nwas\tO\nnot\tO\nsignificantly\tO\ndifferent\tO\namong\tO\ngroups\tO\n,\tO\nbut\tO\nby\tO\nyear\tO\n13\tO\n,\tO\nthe\tO\nsurvival\tO\nof\tO\nthe\tO\npatients\tO\nwho\tT-1\nhad\tT-1\nESRD\tB-Disease\nwas\tO\nonly\tO\n28\tO\n.\tO\n2\tO\n%\tO\ncompared\tO\nwith\tO\n54\tO\n.\tO\n6\tO\n%\tO\nin\tO\nthe\tO\ncontrol\tO\ngroup\tO\n.\tO\n\nPatients\tT-0\ndeveloping\tT-0\nESRD\tB-Disease\nhad\tO\na\tO\n6\tO\n-\tO\nyear\tO\nsurvival\tO\nafter\tO\nonset\tO\nof\tO\nESRD\tO\nof\tO\n27\tO\n%\tO\nfor\tO\nthe\tO\npatients\tT-1\nreceiving\tT-1\nhemodialysis\tT-1\nversus\tO\n71\tO\n.\tO\n4\tO\n%\tO\nfor\tO\nthe\tO\npatients\tT-2\ndeveloping\tT-2\nESRD\tO\nwho\tO\nsubsequently\tO\nreceived\tO\nkidney\tO\ntransplants\tO\n.\tO\n\nPatients\tO\ndeveloping\tT-1\nESRD\tO\nhad\tO\na\tO\n6\tO\n-\tO\nyear\tO\nsurvival\tO\nafter\tO\nonset\tT-0\nof\tT-0\nESRD\tB-Disease\nof\tO\n27\tO\n%\tO\nfor\tO\nthe\tO\npatients\tO\nreceiving\tO\nhemodialysis\tO\nversus\tO\n71\tO\n.\tO\n4\tO\n%\tO\nfor\tO\nthe\tO\npatients\tO\ndeveloping\tO\nESRD\tO\nwho\tO\nsubsequently\tO\nreceived\tO\nkidney\tO\ntransplants\tO\n.\tO\n\nPatients\tO\ndeveloping\tO\nESRD\tO\nhad\tO\na\tO\n6\tO\n-\tO\nyear\tO\nsurvival\tO\nafter\tO\nonset\tO\nof\tO\nESRD\tO\nof\tO\n27\tO\n%\tO\nfor\tO\nthe\tO\npatients\tO\nreceiving\tO\nhemodialysis\tO\nversus\tO\n71\tO\n.\tO\n4\tO\n%\tO\nfor\tO\nthe\tO\npatients\tO\ndeveloping\tT-0\nESRD\tB-Disease\nwho\tO\nsubsequently\tO\nreceived\tO\nkidney\tO\ntransplants\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPatients\tO\nwho\tO\nare\tO\nmore\tT-1\nthan\tT-1\n10\tT-1\nyears\tT-1\npost\tT-1\n-\tO\nOLTX\tT-0\nhave\tO\nCRF\tB-Disease\nand\tO\nESRD\tO\nat\tT-2\na\tT-2\nhigh\tT-2\nrate\tT-2\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nPatients\tT-2\nwho\tO\nare\tO\nmore\tO\nthan\tO\n10\tO\nyears\tO\npost\tO\n-\tO\nOLTX\tO\nhave\tO\nCRF\tT-0\nand\tT-0\nESRD\tB-Disease\nat\tT-1\na\tT-1\nhigh\tT-1\nrate\tT-1\n.\tO\n\nThe\tT-1\ndevelopment\tT-1\nof\tT-1\nESRD\tB-Disease\ndecreases\tT-2\nsurvival\tO\n,\tO\nparticularly\tO\nin\tO\nthose\tO\npatients\tO\ntreated\tO\nwith\tO\ndialysis\tO\nonly\tO\n.\tO\n\nPatients\tT-0\nwho\tT-0\ndevelop\tT-0\nESRD\tB-Disease\nhave\tO\na\tO\nhigher\tO\npreoperative\tO\nand\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tO\nand\tO\nare\tO\nmore\tO\nlikely\tO\nto\tO\nhave\tO\nhepatorenal\tO\nsyndrome\tO\n.\tO\n\nPatients\tO\nwho\tO\ndevelop\tO\nESRD\tO\nhave\tO\na\tO\nhigher\tO\npreoperative\tO\nand\tO\n1\tT-1\n-\tT-1\nyear\tT-1\nserum\tT-0\ncreatinine\tB-Chemical\nand\tO\nare\tO\nmore\tO\nlikely\tO\nto\tO\nhave\tO\nhepatorenal\tO\nsyndrome\tO\n.\tO\n\nPatients\tT-0\nwho\tT-0\ndevelop\tT-0\nESRD\tO\nhave\tO\na\tO\nhigher\tO\npreoperative\tO\nand\tO\n1\tO\n-\tO\nyear\tO\nserum\tO\ncreatinine\tO\nand\tO\nare\tO\nmore\tO\nlikely\tO\nto\tT-1\nhave\tT-1\nhepatorenal\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nHowever\tO\n,\tO\nan\tT-0\nincrease\tT-1\nof\tT-1\nserum\tT-1\ncreatinine\tB-Chemical\nat\tO\nvarious\tO\ntimes\tO\npostoperatively\tO\nis\tO\nmore\tO\npredictive\tO\nof\tO\nthe\tO\ndevelopment\tO\nof\tO\nCRF\tO\nor\tO\nESRD\tO\n.\tO\n\nHowever\tO\n,\tO\nan\tO\nincrease\tO\nof\tO\nserum\tO\ncreatinine\tO\nat\tO\nvarious\tO\ntimes\tO\npostoperatively\tO\nis\tO\nmore\tO\npredictive\tO\nof\tO\nthe\tO\ndevelopment\tT-0\nof\tT-0\nCRF\tB-Disease\nor\tO\nESRD\tO\n.\tO\n\nHowever\tO\n,\tO\nan\tO\nincrease\tO\nof\tO\nserum\tO\ncreatinine\tO\nat\tO\nvarious\tO\ntimes\tO\npostoperatively\tO\nis\tO\nmore\tO\npredictive\tO\nof\tO\nthe\tO\ndevelopment\tT-0\nof\tT-0\nCRF\tO\nor\tO\nESRD\tB-Disease\n.\tO\n\nEpileptic\tB-Disease\nseizures\tI-Disease\nfollowing\tT-2\ncortical\tO\napplication\tO\nof\tO\nfibrin\tT-1\nsealants\tT-1\ncontaining\tO\ntranexamic\tO\nacid\tO\nin\tO\nrats\tO\n.\tO\n\nEpileptic\tO\nseizures\tO\nfollowing\tO\ncortical\tO\napplication\tO\nof\tO\nfibrin\tO\nsealants\tO\ncontaining\tT-1\ntranexamic\tB-Chemical\nacid\tI-Chemical\nin\tT-0\nrats\tT-0\n.\tO\n\nRecently\tO\n,\tO\nsynthetic\tO\nfibrinolysis\tO\ninhibitors\tT-1\nsuch\tO\nas\tO\ntranexamic\tB-Chemical\nacid\tI-Chemical\n(\tT-0\ntAMCA\tT-0\n)\tT-0\nhave\tO\nbeen\tO\nconsidered\tO\nas\tO\nsubstitutes\tT-2\nfor\tO\naprotinin\tO\n.\tO\n\nRecently\tO\n,\tO\nsynthetic\tO\nfibrinolysis\tO\ninhibitors\tT-1\nsuch\tO\nas\tO\ntranexamic\tO\nacid\tO\n(\tO\ntAMCA\tB-Chemical\n)\tO\nhave\tT-0\nbeen\tT-0\nconsidered\tT-2\nas\tT-2\nsubstitutes\tT-2\nfor\tO\naprotinin\tO\n.\tO\n\nHowever\tO\n,\tO\ntAMCA\tB-Chemical\nhas\tT-0\nbeen\tT-0\nshown\tT-0\nto\tO\ncause\tO\nepileptic\tO\nseizures\tO\n.\tO\n\nHowever\tO\n,\tO\ntAMCA\tO\nhas\tO\nbeen\tO\nshown\tT-0\nto\tT-0\ncause\tT-0\nepileptic\tB-Disease\nseizures\tI-Disease\n.\tO\n\nWe\tO\nwanted\tO\nto\tO\nstudy\tO\nwhether\tO\ntAMCA\tB-Chemical\nretains\tT-1\nits\tO\nconvulsive\tO\naction\tO\nif\tO\nincorporated\tO\ninto\tO\na\tO\nFS\tO\n.\tO\n\nWe\tO\nwanted\tO\nto\tO\nstudy\tO\nwhether\tO\ntAMCA\tO\nretains\tT-1\nits\tT-1\nconvulsive\tB-Disease\naction\tT-0\nif\tO\nincorporated\tO\ninto\tO\na\tO\nFS\tO\n.\tO\n\nMETHOD\tO\n:\tO\nFS\tO\ncontaining\tO\naprotinin\tO\nor\tO\ndifferent\tO\nconcentrations\tT-0\nof\tT-0\ntAMCA\tB-Chemical\n(\tO\n0\tO\n.\tO\n5\tO\n-\tO\n47\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\n)\tO\nwere\tO\napplied\tO\nto\tO\nthe\tO\npial\tO\nsurface\tO\nof\tO\nthe\tO\ncortex\tO\nof\tO\nanaesthetized\tO\nrats\tO\n.\tO\n\nFINDINGS\tO\n:\tO\nFS\tT-0\ncontaining\tT-2\ntAMCA\tB-Chemical\ncaused\tO\nparoxysmal\tO\nbrain\tO\nactivity\tO\nwhich\tO\nwas\tO\nassociated\tT-1\nwith\tT-1\ndistinct\tT-1\nconvulsive\tT-1\nbehaviours\tT-1\n.\tO\n\nFINDINGS\tO\n:\tO\nFS\tO\ncontaining\tO\ntAMCA\tO\ncaused\tO\nparoxysmal\tT-2\nbrain\tT-2\nactivity\tT-2\nwhich\tO\nwas\tO\nassociated\tT-0\nwith\tT-0\ndistinct\tT-1\nconvulsive\tB-Disease\nbehaviours\tT-3\n.\tO\n\nThe\tO\ndegree\tO\nof\tO\nthese\tT-0\nseizures\tB-Disease\nincreased\tT-1\nwith\tO\nincreasing\tO\nconcentration\tO\nof\tO\ntAMCA\tO\n.\tO\n\nThe\tO\ndegree\tO\nof\tO\nthese\tO\nseizures\tO\nincreased\tO\nwith\tO\nincreasing\tT-0\nconcentration\tT-0\nof\tT-0\ntAMCA\tB-Chemical\n.\tO\n\nThus\tO\n,\tO\nFS\tO\ncontaining\tT-0\n47\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\ntAMCA\tB-Chemical\nevoked\tO\ngeneralized\tO\nseizures\tO\nin\tO\nall\tO\ntested\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nwhile\tO\nthe\tO\nlowest\tO\nconcentration\tO\nof\tO\ntAMCA\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\n)\tO\nonly\tO\nevoked\tO\nbrief\tO\nepisodes\tO\nof\tO\njerk\tO\n-\tO\ncorrelated\tO\nconvulsive\tO\npotentials\tO\nin\tO\n1\tO\nof\tO\n6\tO\nrats\tO\n.\tO\n\nThus\tO\n,\tO\nFS\tO\ncontaining\tO\n47\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\ntAMCA\tO\nevoked\tT-0\ngeneralized\tB-Disease\nseizures\tI-Disease\nin\tO\nall\tO\ntested\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nwhile\tO\nthe\tO\nlowest\tO\nconcentration\tO\nof\tO\ntAMCA\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\n)\tO\nonly\tO\nevoked\tO\nbrief\tO\nepisodes\tO\nof\tO\njerk\tO\n-\tO\ncorrelated\tO\nconvulsive\tO\npotentials\tO\nin\tO\n1\tO\nof\tO\n6\tO\nrats\tO\n.\tO\n\nThus\tO\n,\tO\nFS\tO\ncontaining\tO\n47\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\ntAMCA\tO\nevoked\tO\ngeneralized\tO\nseizures\tO\nin\tO\nall\tO\ntested\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nwhile\tO\nthe\tO\nlowest\tO\nconcentration\tT-0\nof\tT-0\ntAMCA\tB-Chemical\n(\tT-1\n0\tT-1\n.\tT-1\n5\tT-1\nmg\tT-1\n/\tT-1\nml\tT-1\n)\tT-1\nonly\tO\nevoked\tO\nbrief\tO\nepisodes\tO\nof\tO\njerk\tO\n-\tO\ncorrelated\tO\nconvulsive\tO\npotentials\tO\nin\tO\n1\tO\nof\tO\n6\tO\nrats\tO\n.\tO\n\nThus\tO\n,\tO\nFS\tO\ncontaining\tO\n47\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\ntAMCA\tO\nevoked\tO\ngeneralized\tO\nseizures\tO\nin\tO\nall\tO\ntested\tO\nrats\tO\n(\tO\nn\tO\n=\tO\n6\tO\n)\tO\nwhile\tO\nthe\tO\nlowest\tO\nconcentration\tO\nof\tO\ntAMCA\tO\n(\tO\n0\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nml\tO\n)\tO\nonly\tO\nevoked\tO\nbrief\tO\nepisodes\tO\nof\tO\njerk\tO\n-\tO\ncorrelated\tT-0\nconvulsive\tB-Disease\npotentials\tO\nin\tO\n1\tO\nof\tO\n6\tO\nrats\tO\n.\tO\n\nINTERPRETATION\tT-1\n:\tO\nTranexamic\tB-Chemical\nacid\tI-Chemical\nretains\tT-0\nits\tO\nconvulsive\tO\naction\tO\nwithin\tO\nFS\tO\n.\tO\n\nINTERPRETATION\tO\n:\tO\nTranexamic\tT-0\nacid\tT-0\nretains\tT-0\nits\tO\nconvulsive\tB-Disease\naction\tT-1\nwithin\tT-1\nFS\tT-1\n.\tO\n\nThus\tO\n,\tO\nuse\tO\nof\tO\nFS\tO\ncontaining\tT-0\ntAMCA\tB-Chemical\nfor\tO\nsurgery\tO\nwithin\tO\nor\tO\nclose\tO\nto\tO\nthe\tO\nCNS\tO\nmay\tO\npose\tO\na\tO\nsubstantial\tO\nrisk\tO\nto\tO\nthe\tO\npatient\tO\n.\tO\n\nSequential\tO\nobservations\tT-0\nof\tT-0\nexencephaly\tB-Disease\nand\tO\nsubsequent\tO\nmorphological\tO\nchanges\tO\nby\tO\nmouse\tO\nexo\tO\nutero\tO\ndevelopment\tO\nsystem\tO\n:\tO\nanalysis\tO\nof\tO\nthe\tO\nmechanism\tO\nof\tO\ntransformation\tO\nfrom\tO\nexencephaly\tO\nto\tO\nanencephaly\tO\n.\tO\n\nSequential\tO\nobservations\tO\nof\tO\nexencephaly\tO\nand\tO\nsubsequent\tO\nmorphological\tO\nchanges\tO\nby\tO\nmouse\tO\nexo\tO\nutero\tO\ndevelopment\tO\nsystem\tO\n:\tO\nanalysis\tT-0\nof\tT-0\nthe\tT-0\nmechanism\tT-0\nof\tT-0\ntransformation\tT-2\nfrom\tT-2\nexencephaly\tB-Disease\nto\tO\nanencephaly\tT-1\n.\tO\n\nSequential\tO\nobservations\tO\nof\tO\nexencephaly\tO\nand\tO\nsubsequent\tO\nmorphological\tO\nchanges\tO\nby\tO\nmouse\tO\nexo\tO\nutero\tO\ndevelopment\tO\nsystem\tO\n:\tO\nanalysis\tO\nof\tO\nthe\tO\nmechanism\tO\nof\tO\ntransformation\tT-1\nfrom\tO\nexencephaly\tT-0\nto\tT-0\nanencephaly\tB-Disease\n.\tO\n\nAnencephaly\tB-Disease\nhas\tT-0\nbeen\tT-0\nsuggested\tT-0\nto\tO\ndevelop\tO\nfrom\tO\nexencephaly\tO\n;\tO\nhowever\tO\n,\tO\nthere\tO\nis\tO\nlittle\tO\ndirect\tO\nexperimental\tO\nevidence\tO\nto\tO\nsupport\tO\nthis\tO\n,\tO\nand\tO\nthe\tO\nmechanism\tO\nof\tO\ntransformation\tO\nremains\tO\nunclear\tO\n.\tO\n\nAnencephaly\tO\nhas\tO\nbeen\tO\nsuggested\tO\nto\tO\ndevelop\tT-0\nfrom\tT-0\nexencephaly\tB-Disease\n;\tO\nhowever\tO\n,\tO\nthere\tO\nis\tO\nlittle\tO\ndirect\tO\nexperimental\tO\nevidence\tO\nto\tO\nsupport\tO\nthis\tO\n,\tO\nand\tO\nthe\tO\nmechanism\tO\nof\tO\ntransformation\tO\nremains\tO\nunclear\tO\n.\tO\n\nWe\tO\nobserved\tT-1\nthe\tT-1\nexencephaly\tB-Disease\ninduced\tT-2\nby\tO\n5\tO\n-\tO\nazacytidine\tO\nat\tO\nembryonic\tO\nday\tO\n13\tO\n.\tO\n5\tO\n(\tO\nE13\tO\n.\tO\n5\tO\n)\tO\n,\tO\nlet\tO\nthe\tO\nembryos\tO\ndevelop\tO\nexo\tO\nutero\tO\nuntil\tO\nE18\tO\n.\tO\n5\tO\n,\tO\nand\tO\nre\tO\n-\tO\nobserved\tO\nthe\tO\nsame\tO\nembryos\tO\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nWe\tO\nobserved\tO\nthe\tO\nexencephaly\tT-1\ninduced\tT-1\nby\tT-0\n5\tB-Chemical\n-\tI-Chemical\nazacytidine\tI-Chemical\nat\tO\nembryonic\tT-2\nday\tT-2\n13\tT-2\n.\tO\n5\tO\n(\tO\nE13\tO\n.\tO\n5\tO\n)\tO\n,\tO\nlet\tO\nthe\tO\nembryos\tO\ndevelop\tO\nexo\tO\nutero\tO\nuntil\tO\nE18\tO\n.\tO\n5\tO\n,\tO\nand\tO\nre\tO\n-\tO\nobserved\tO\nthe\tO\nsame\tO\nembryos\tO\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nWe\tO\nconfirmed\tO\nseveral\tO\ncases\tT-2\nof\tT-2\ntransformation\tT-2\nfrom\tT-0\nexencephaly\tB-Disease\nto\tT-1\nanencephaly\tT-1\n.\tO\n\nWe\tO\nconfirmed\tO\nseveral\tO\ncases\tO\nof\tO\ntransformation\tT-0\nfrom\tT-0\nexencephaly\tT-0\nto\tT-0\nanencephaly\tB-Disease\n.\tO\n\nHowever\tO\n,\tO\nin\tO\nmany\tO\ncases\tO\n,\tO\nthe\tO\nexencephalic\tB-Disease\nbrain\tO\ntissue\tO\nwas\tO\npreserved\tO\nwith\tO\nmore\tT-0\nor\tT-0\nless\tT-0\nreduction\tT-0\nduring\tO\nthis\tO\nperiod\tO\n.\tO\n\nTo\tO\nanalyze\tO\nthe\tO\ntransformation\tO\npatterns\tO\n,\tO\nwe\tT-0\nclassified\tT-0\nthe\tT-0\nexencephaly\tB-Disease\nby\tO\nsize\tO\nand\tO\nshape\tO\nof\tO\nthe\tO\nexencephalic\tO\ntissue\tO\ninto\tO\nseveral\tO\ntypes\tO\nat\tO\nE13\tO\n.\tO\n5\tO\nand\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nTo\tO\nanalyze\tO\nthe\tO\ntransformation\tO\npatterns\tO\n,\tO\nwe\tO\nclassified\tT-1\nthe\tT-1\nexencephaly\tT-1\nby\tO\nsize\tO\nand\tO\nshape\tO\nof\tO\nthe\tO\nexencephalic\tB-Disease\ntissue\tT-2\ninto\tO\nseveral\tO\ntypes\tO\nat\tO\nE13\tO\n.\tO\n5\tO\nand\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nIt\tO\nwas\tO\nfound\tO\nthat\tO\nthe\tO\ntransformation\tT-0\nof\tO\nexencephalic\tB-Disease\ntissue\tO\nwas\tO\nnot\tO\nsimply\tO\nsize\tO\n-\tO\ndependent\tO\n,\tO\nand\tO\nall\tO\ncases\tO\nof\tO\nanencephaly\tO\nat\tO\nE18\tO\n.\tO\n5\tO\nresulted\tT-1\nfrom\tT-1\nembryos\tO\nwith\tO\na\tO\nlarge\tO\namount\tO\nof\tO\nexencephalic\tO\ntissue\tO\nat\tO\nE13\tO\n.\tO\n5\tO\n.\tO\n\nIt\tO\nwas\tO\nfound\tO\nthat\tO\nthe\tO\ntransformation\tO\nof\tO\nexencephalic\tO\ntissue\tO\nwas\tO\nnot\tO\nsimply\tO\nsize\tO\n-\tO\ndependent\tO\n,\tO\nand\tO\nall\tO\ncases\tT-0\nof\tT-0\nanencephaly\tB-Disease\nat\tT-1\nE18\tT-1\n.\tO\n5\tO\nresulted\tO\nfrom\tO\nembryos\tO\nwith\tO\na\tO\nlarge\tO\namount\tO\nof\tO\nexencephalic\tO\ntissue\tO\nat\tO\nE13\tO\n.\tO\n5\tO\n.\tO\n\nIt\tO\nwas\tO\nfound\tO\nthat\tO\nthe\tO\ntransformation\tO\nof\tO\nexencephalic\tO\ntissue\tO\nwas\tO\nnot\tO\nsimply\tO\nsize\tO\n-\tO\ndependent\tO\n,\tO\nand\tO\nall\tO\ncases\tO\nof\tO\nanencephaly\tO\nat\tO\nE18\tO\n.\tO\n5\tO\nresulted\tO\nfrom\tO\nembryos\tO\nwith\tO\na\tO\nlarge\tT-0\namount\tT-0\nof\tT-0\nexencephalic\tB-Disease\ntissue\tT-1\nat\tO\nE13\tO\n.\tO\n5\tO\n.\tO\n\nMicroscopic\tO\nobservation\tT-0\nshowed\tO\nthe\tO\nconfiguration\tT-3\nof\tT-3\nexencephaly\tB-Disease\nat\tO\nE13\tO\n.\tO\n5\tO\n,\tO\nfrequent\tO\nhemorrhaging\tO\nand\tO\ndetachment\tO\nof\tO\nthe\tO\nneural\tO\nplate\tO\nfrom\tO\nsurface\tO\nectoderm\tO\nin\tO\nthe\tO\nexencephalic\tO\nhead\tO\nat\tO\nE15\tO\n.\tO\n5\tO\n,\tO\nand\tO\nmultiple\tO\nmodes\tO\nof\tO\nreduction\tT-2\nin\tO\nthe\tO\nexencephalic\tO\ntissue\tO\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nMicroscopic\tO\nobservation\tO\nshowed\tO\nthe\tO\nconfiguration\tO\nof\tO\nexencephaly\tO\nat\tO\nE13\tO\n.\tO\n5\tO\n,\tO\nfrequent\tT-0\nhemorrhaging\tB-Disease\nand\tO\ndetachment\tO\nof\tO\nthe\tO\nneural\tO\nplate\tO\nfrom\tO\nsurface\tO\nectoderm\tO\nin\tO\nthe\tO\nexencephalic\tO\nhead\tO\nat\tO\nE15\tO\n.\tO\n5\tO\n,\tO\nand\tO\nmultiple\tO\nmodes\tO\nof\tO\nreduction\tO\nin\tO\nthe\tO\nexencephalic\tO\ntissue\tO\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nMicroscopic\tO\nobservation\tO\nshowed\tO\nthe\tO\nconfiguration\tO\nof\tO\nexencephaly\tO\nat\tO\nE13\tO\n.\tO\n5\tO\n,\tO\nfrequent\tO\nhemorrhaging\tO\nand\tO\ndetachment\tO\nof\tO\nthe\tO\nneural\tO\nplate\tO\nfrom\tO\nsurface\tO\nectoderm\tO\nin\tT-0\nthe\tT-0\nexencephalic\tB-Disease\nhead\tT-1\nat\tO\nE15\tO\n.\tO\n5\tO\n,\tO\nand\tO\nmultiple\tO\nmodes\tO\nof\tO\nreduction\tO\nin\tO\nthe\tO\nexencephalic\tO\ntissue\tO\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nMicroscopic\tO\nobservation\tO\nshowed\tO\nthe\tO\nconfiguration\tO\nof\tO\nexencephaly\tO\nat\tO\nE13\tO\n.\tO\n5\tO\n,\tO\nfrequent\tO\nhemorrhaging\tO\nand\tO\ndetachment\tO\nof\tO\nthe\tO\nneural\tO\nplate\tO\nfrom\tO\nsurface\tO\nectoderm\tO\nin\tO\nthe\tO\nexencephalic\tO\nhead\tO\nat\tO\nE15\tO\n.\tO\n5\tO\n,\tO\nand\tO\nmultiple\tO\nmodes\tO\nof\tO\nreduction\tT-0\nin\tT-0\nthe\tO\nexencephalic\tB-Disease\ntissue\tT-1\nat\tO\nE18\tO\n.\tO\n5\tO\n.\tO\n\nFrom\tO\nobservations\tO\nof\tO\nthe\tO\nvasculature\tO\n,\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\nwere\tO\nidentified\tT-0\nin\tT-0\nthe\tT-0\nexencephalic\tB-Disease\nhead\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\novergrowth\tT-1\nof\tT-1\nthe\tO\nexencephalic\tB-Disease\nneural\tT-0\ntissue\tT-0\ncauses\tO\nthe\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\n,\tO\nsubsequent\tO\nperipheral\tO\ncirculatory\tO\nfailure\tO\nand\tO\n/\tO\nor\tO\nhemorrhaging\tO\nin\tO\nvarious\tO\nparts\tO\nof\tO\nthe\tO\nexencephalic\tO\nhead\tO\n,\tO\nleading\tO\nto\tO\nthe\tO\nmultiple\tO\nmodes\tO\nof\tO\ntissue\tO\nreduction\tO\nduring\tO\ntransformation\tO\nfrom\tO\nexencephaly\tO\nto\tO\nanencephaly\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\novergrowth\tO\nof\tO\nthe\tO\nexencephalic\tO\nneural\tO\ntissue\tO\ncauses\tT-0\nthe\tT-0\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\n,\tO\nsubsequent\tT-1\nperipheral\tT-1\ncirculatory\tB-Disease\nfailure\tI-Disease\nand\tO\n/\tO\nor\tO\nhemorrhaging\tO\nin\tO\nvarious\tO\nparts\tO\nof\tO\nthe\tO\nexencephalic\tO\nhead\tO\n,\tO\nleading\tO\nto\tO\nthe\tO\nmultiple\tO\nmodes\tO\nof\tO\ntissue\tO\nreduction\tO\nduring\tO\ntransformation\tO\nfrom\tO\nexencephaly\tO\nto\tO\nanencephaly\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\novergrowth\tT-3\nof\tT-3\nthe\tO\nexencephalic\tO\nneural\tO\ntissue\tO\ncauses\tO\nthe\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\n,\tO\nsubsequent\tT-1\nperipheral\tT-1\ncirculatory\tT-1\nfailure\tT-1\nand\tO\n/\tO\nor\tO\nhemorrhaging\tB-Disease\nin\tO\nvarious\tT-2\nparts\tT-2\nof\tT-2\nthe\tT-2\nexencephalic\tT-2\nhead\tT-2\n,\tO\nleading\tO\nto\tO\nthe\tO\nmultiple\tO\nmodes\tO\nof\tO\ntissue\tO\nreduction\tO\nduring\tO\ntransformation\tO\nfrom\tO\nexencephaly\tO\nto\tO\nanencephaly\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\novergrowth\tO\nof\tO\nthe\tO\nexencephalic\tO\nneural\tO\ntissue\tO\ncauses\tO\nthe\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\n,\tO\nsubsequent\tO\nperipheral\tT-0\ncirculatory\tT-0\nfailure\tT-2\nand\tT-2\n/\tT-2\nor\tT-2\nhemorrhaging\tT-2\nin\tT-2\nvarious\tT-2\nparts\tT-2\nof\tO\nthe\tO\nexencephalic\tB-Disease\nhead\tO\n,\tO\nleading\tT-3\nto\tT-3\nthe\tO\nmultiple\tO\nmodes\tO\nof\tO\ntissue\tO\nreduction\tO\nduring\tO\ntransformation\tO\nfrom\tO\nexencephaly\tO\nto\tO\nanencephaly\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\novergrowth\tT-0\nof\tO\nthe\tO\nexencephalic\tO\nneural\tO\ntissue\tO\ncauses\tO\nthe\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\n,\tO\nsubsequent\tO\nperipheral\tO\ncirculatory\tO\nfailure\tO\nand\tO\n/\tO\nor\tO\nhemorrhaging\tO\nin\tO\nvarious\tO\nparts\tO\nof\tO\nthe\tO\nexencephalic\tO\nhead\tO\n,\tO\nleading\tO\nto\tO\nthe\tO\nmultiple\tO\nmodes\tO\nof\tO\ntissue\tO\nreduction\tO\nduring\tO\ntransformation\tT-1\nfrom\tO\nexencephaly\tB-Disease\nto\tO\nanencephaly\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\novergrowth\tO\nof\tO\nthe\tO\nexencephalic\tO\nneural\tO\ntissue\tO\ncauses\tO\nthe\tO\naltered\tO\ndistribution\tO\npatterns\tO\nof\tO\nvessels\tO\n,\tO\nsubsequent\tO\nperipheral\tO\ncirculatory\tO\nfailure\tO\nand\tO\n/\tO\nor\tO\nhemorrhaging\tO\nin\tO\nvarious\tO\nparts\tO\nof\tO\nthe\tO\nexencephalic\tO\nhead\tO\n,\tO\nleading\tO\nto\tO\nthe\tO\nmultiple\tO\nmodes\tO\nof\tO\ntissue\tO\nreduction\tO\nduring\tO\ntransformation\tT-1\nfrom\tT-1\nexencephaly\tT-0\nto\tO\nanencephaly\tB-Disease\n.\tO\n\n99mTc\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nfor\tO\ndetection\tO\nof\tO\nisoproterenol\tO\n-\tO\ninduced\tT-0\nmyocardial\tO\ninfarction\tO\nin\tO\nrats\tO\n.\tO\n\n99mTc\tO\n-\tO\nglucarate\tO\nfor\tO\ndetection\tT-0\nof\tT-0\nisoproterenol\tB-Chemical\n-\tO\ninduced\tT-1\nmyocardial\tO\ninfarction\tO\nin\tO\nrats\tO\n.\tO\n\n99mTc\tO\n-\tO\nglucarate\tO\nfor\tO\ndetection\tO\nof\tO\nisoproterenol\tO\n-\tO\ninduced\tT-1\nmyocardial\tB-Disease\ninfarction\tI-Disease\nin\tT-0\nrats\tT-0\n.\tO\n\nInfarct\tO\n-\tO\navid\tO\nradiopharmaceuticals\tO\nare\tO\nnecessary\tO\nfor\tO\nrapid\tO\nand\tO\ntimely\tO\ndiagnosis\tT-0\nof\tT-0\nacute\tT-1\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nThe\tO\nanimal\tO\nmodel\tO\nused\tO\nto\tT-0\nproduce\tT-1\ninfarction\tB-Disease\nimplies\tT-2\nartery\tO\nligation\tO\nbut\tO\nchemical\tO\ninduction\tO\ncan\tO\nbe\tO\neasily\tO\nobtained\tO\nwith\tO\nisoproterenol\tO\n.\tO\n\nThe\tO\nanimal\tO\nmodel\tT-0\nused\tT-0\nto\tT-0\nproduce\tT-0\ninfarction\tT-0\nimplies\tO\nartery\tO\nligation\tO\nbut\tO\nchemical\tO\ninduction\tO\ncan\tO\nbe\tO\neasily\tO\nobtained\tT-1\nwith\tT-1\nisoproterenol\tB-Chemical\n.\tO\n\nA\tO\nnew\tO\ninfarct\tB-Disease\n-\tO\navid\tT-0\nradiopharmaceutical\tO\nbased\tO\non\tO\nglucaric\tO\nacid\tO\nwas\tO\nprepared\tO\nin\tO\nthe\tO\nhospital\tO\nradiopharmacy\tO\nof\tO\nthe\tO\nINCMNSZ\tO\n.\tO\n\nA\tO\nnew\tO\ninfarct\tO\n-\tO\navid\tO\nradiopharmaceutical\tO\nbased\tT-1\non\tT-1\nglucaric\tB-Chemical\nacid\tI-Chemical\nwas\tT-0\nprepared\tT-0\nin\tT-0\nthe\tT-0\nhospital\tT-0\nradiopharmacy\tT-0\nof\tO\nthe\tO\nINCMNSZ\tO\n.\tO\n\n99mTc\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nwas\tT-0\neasy\tT-0\nto\tT-0\nprepare\tT-0\n,\tO\nstable\tO\nfor\tO\n96\tO\nh\tO\nand\tO\nwas\tO\nused\tO\nto\tO\nstudy\tO\nits\tO\nbiodistribution\tO\nin\tO\nrats\tO\nwith\tO\nisoproterenol\tO\n-\tO\ninduced\tT-1\nacute\tO\nmyocardial\tO\ninfarction\tO\n.\tO\n\n99mTc\tO\n-\tO\nglucarate\tO\nwas\tO\neasy\tO\nto\tO\nprepare\tO\n,\tO\nstable\tO\nfor\tO\n96\tO\nh\tO\nand\tO\nwas\tO\nused\tO\nto\tO\nstudy\tO\nits\tO\nbiodistribution\tO\nin\tO\nrats\tT-0\nwith\tT-0\nisoproterenol\tB-Chemical\n-\tO\ninduced\tT-1\nacute\tO\nmyocardial\tO\ninfarction\tO\n.\tO\n\n99mTc\tO\n-\tO\nglucarate\tO\nwas\tO\neasy\tO\nto\tO\nprepare\tO\n,\tO\nstable\tO\nfor\tO\n96\tO\nh\tO\nand\tO\nwas\tO\nused\tO\nto\tO\nstudy\tO\nits\tO\nbiodistribution\tO\nin\tO\nrats\tO\nwith\tO\nisoproterenol\tO\n-\tO\ninduced\tT-0\nacute\tT-0\nmyocardial\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nHistological\tO\nstudies\tO\ndemonstrated\tO\nthat\tO\nthe\tO\nrats\tO\ndeveloped\tT-2\nan\tT-2\ninfarct\tB-Disease\n18\tO\nh\tO\nafter\tT-1\nisoproterenol\tO\nadministration\tO\n.\tO\n\nHistological\tO\nstudies\tO\ndemonstrated\tO\nthat\tO\nthe\tO\nrats\tO\ndeveloped\tO\nan\tO\ninfarct\tO\n18\tO\nh\tO\nafter\tT-0\nisoproterenol\tB-Chemical\nadministration\tT-1\n.\tO\n\nThirty\tO\nminutes\tO\nafter\tO\n99mTc\tB-Chemical\n-\tI-Chemical\nglucarate\tI-Chemical\nadministration\tT-0\nthe\tO\nstandardised\tO\nheart\tO\nuptake\tO\nvalue\tO\nS\tO\n(\tO\nh\tO\n)\tO\nUV\tO\nwas\tO\n4\tO\n.\tO\n7\tO\nin\tO\ninfarcted\tO\nrat\tO\nheart\tO\nwhich\tO\nis\tO\nsix\tO\ntimes\tO\nmore\tO\nthan\tO\nin\tO\nnormal\tO\nrats\tO\n.\tO\n\nThe\tO\nhigh\tO\nimage\tO\nquality\tO\nsuggests\tO\nthat\tO\nhigh\tO\ncontrast\tO\nimages\tO\ncan\tO\nbe\tO\nobtained\tO\nin\tO\nhumans\tO\nand\tO\nthe\tO\n96\tO\nh\tO\nstability\tO\nmakes\tO\nit\tO\nan\tO\nideal\tO\nagent\tO\nto\tT-0\ndetect\tT-0\n,\tO\nin\tO\npatients\tO\n,\tO\nearly\tO\ncardiac\tB-Disease\ninfarction\tI-Disease\n.\tO\n\nBupropion\tB-Chemical\n(\tO\nZyban\tO\n)\tO\ntoxicity\tT-0\n.\tO\n\nBupropion\tT-0\n(\tO\nZyban\tB-Chemical\n)\tO\ntoxicity\tT-1\n.\tO\n\nBupropion\tT-0\n(\tO\nZyban\tO\n)\tO\ntoxicity\tB-Disease\n.\tO\n\nBupropion\tB-Chemical\nis\tT-0\na\tT-0\nmonocyclic\tO\nantidepressant\tO\nstructurally\tO\nrelated\tO\nto\tO\namphetamine\tO\n.\tO\n\nBupropion\tT-1\nis\tT-1\na\tT-1\nmonocyclic\tT-1\nantidepressant\tB-Chemical\nstructurally\tT-2\nrelated\tT-2\nto\tT-2\namphetamine\tT-2\n.\tO\n\nBupropion\tO\nis\tO\na\tO\nmonocyclic\tO\nantidepressant\tT-0\nstructurally\tO\nrelated\tT-1\nto\tT-1\namphetamine\tB-Chemical\n.\tO\n\nZyban\tB-Chemical\n,\tO\na\tT-1\nsustained\tT-1\n-\tT-0\nrelease\tT-0\nformulation\tT-0\nof\tO\nbupropion\tO\nhydrochloride\tO\n,\tO\nwas\tO\nrecently\tO\nreleased\tO\nin\tO\nIreland\tO\n,\tO\nas\tO\na\tO\nsmoking\tO\ncessation\tO\naid\tO\n.\tO\n\nZyban\tO\n,\tO\na\tO\nsustained\tO\n-\tO\nrelease\tO\nformulation\tT-0\nof\tT-0\nbupropion\tB-Chemical\nhydrochloride\tI-Chemical\n,\tO\nwas\tO\nrecently\tO\nreleased\tO\nin\tO\nIreland\tO\n,\tO\nas\tO\na\tO\nsmoking\tO\ncessation\tO\naid\tO\n.\tO\n\nIn\tO\nthe\tO\ninitial\tO\n6\tO\nmonths\tO\nsince\tO\nit\tO\n'\tO\ns\tO\nintroduction\tO\n,\tO\n12\tO\noverdose\tB-Disease\ncases\tT-0\nhave\tO\nbeen\tO\nreported\tO\nto\tO\nThe\tO\nNational\tO\nPoisons\tO\nInformation\tO\nCentre\tO\n.\tO\n\n8\tO\npatients\tO\ndeveloped\tO\nsymptoms\tT-0\nof\tT-0\ntoxicity\tB-Disease\n.\tO\n\nCommon\tO\nfeatures\tO\nincluded\tT-0\ntachycardia\tB-Disease\n,\tO\ndrowsiness\tT-1\n,\tO\nhallucinations\tO\nand\tO\nconvulsions\tO\n.\tO\n\nCommon\tT-2\nfeatures\tT-2\nincluded\tT-0\ntachycardia\tO\n,\tO\ndrowsiness\tT-1\n,\tO\nhallucinations\tB-Disease\nand\tO\nconvulsions\tO\n.\tO\n\nCommon\tT-1\nfeatures\tT-1\nincluded\tO\ntachycardia\tT-0\n,\tO\ndrowsiness\tO\n,\tO\nhallucinations\tO\nand\tO\nconvulsions\tB-Disease\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tT-1\nsevere\tT-1\ncardiac\tB-Disease\narrhythmias\tI-Disease\n,\tO\nincluding\tT-0\none\tT-0\npatient\tT-0\nwho\tO\nwas\tO\nresuscitated\tO\nfollowing\tO\na\tO\ncardiac\tO\narrest\tO\n.\tO\n\nTwo\tO\npatients\tO\ndeveloped\tO\nsevere\tO\ncardiac\tO\narrhythmias\tO\n,\tO\nincluding\tO\none\tO\npatient\tO\nwho\tO\nwas\tO\nresuscitated\tT-0\nfollowing\tT-0\na\tT-0\ncardiac\tB-Disease\narrest\tI-Disease\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\n31\tO\nyear\tO\nold\tO\nfemale\tO\nwho\tO\nrequired\tO\nadmission\tO\nto\tO\nthe\tO\nIntensive\tO\nCare\tO\nUnit\tO\nfor\tO\nventilation\tO\nand\tO\nfull\tO\nsupportive\tO\ntherapy\tO\n,\tO\nfollowing\tO\ningestion\tT-0\nof\tT-0\n13\tO\n.\tO\n5g\tO\nbupropion\tB-Chemical\n.\tO\n\nRecurrent\tT-1\nseizures\tB-Disease\nwere\tT-0\ntreated\tT-0\nwith\tO\ndiazepam\tO\nand\tO\nbroad\tO\ncomplex\tO\ntachycardia\tO\nwas\tO\nsuccessfully\tO\ntreated\tO\nwith\tO\nadenosine\tO\n.\tO\n\nRecurrent\tT-2\nseizures\tT-2\nwere\tT-0\ntreated\tT-3\nwith\tT-3\ndiazepam\tB-Chemical\nand\tO\nbroad\tO\ncomplex\tO\ntachycardia\tO\nwas\tO\nsuccessfully\tT-1\ntreated\tT-1\nwith\tT-1\nadenosine\tO\n.\tO\n\nRecurrent\tO\nseizures\tO\nwere\tO\ntreated\tT-0\nwith\tO\ndiazepam\tO\nand\tO\nbroad\tO\ncomplex\tO\ntachycardia\tB-Disease\nwas\tO\nsuccessfully\tO\ntreated\tT-1\nwith\tO\nadenosine\tO\n.\tO\n\nRecurrent\tO\nseizures\tO\nwere\tO\ntreated\tO\nwith\tO\ndiazepam\tT-1\nand\tO\nbroad\tO\ncomplex\tO\ntachycardia\tO\nwas\tO\nsuccessfully\tT-0\ntreated\tT-2\nwith\tT-2\nadenosine\tB-Chemical\n.\tO\n\nZyban\tB-Chemical\ncaused\tO\nsignificant\tO\nneurological\tO\nand\tO\ncardiovascular\tO\ntoxicity\tT-1\nin\tT-0\noverdose\tT-0\n.\tO\n\nZyban\tO\ncaused\tT-0\nsignificant\tT-0\nneurological\tB-Disease\nand\tI-Disease\ncardiovascular\tI-Disease\ntoxicity\tI-Disease\nin\tO\noverdose\tO\n.\tO\n\nZyban\tO\ncaused\tT-0\nsignificant\tO\nneurological\tO\nand\tO\ncardiovascular\tO\ntoxicity\tO\nin\tO\noverdose\tB-Disease\n.\tO\n\nGLEPP1\tT-0\nreceptor\tT-0\ntyrosine\tB-Chemical\nphosphatase\tO\n(\tO\nPtpro\tO\n)\tO\nin\tT-1\nrat\tT-1\nPAN\tT-1\nnephrosis\tT-1\n.\tO\n\nGLEPP1\tO\nreceptor\tO\ntyrosine\tO\nphosphatase\tO\n(\tO\nPtpro\tO\n)\tO\nin\tT-0\nrat\tT-0\nPAN\tB-Chemical\nnephrosis\tT-1\n.\tT-1\n\nGLEPP1\tO\nreceptor\tO\ntyrosine\tO\nphosphatase\tO\n(\tO\nPtpro\tO\n)\tO\nin\tT-0\nrat\tO\nPAN\tO\nnephrosis\tB-Disease\n.\tO\n\nGlomerular\tO\nepithelial\tO\nprotein\tO\n1\tO\n(\tO\nGLEPP1\tO\n)\tO\nis\tO\na\tO\npodocyte\tO\nreceptor\tT-0\nmembrane\tT-0\nprotein\tT-0\ntyrosine\tB-Chemical\nphosphatase\tT-1\nlocated\tO\non\tO\nthe\tO\napical\tO\ncell\tO\nmembrane\tO\nof\tO\nvisceral\tO\nglomerular\tO\nepithelial\tO\ncell\tO\nand\tO\nfoot\tO\nprocesses\tO\n.\tO\n\nTo\tO\nbetter\tO\nunderstand\tO\nthe\tO\nutility\tT-2\nof\tT-2\nGLEPP1\tT-2\nas\tT-2\na\tT-2\nmarker\tT-2\nof\tT-1\nglomerular\tB-Disease\ninjury\tI-Disease\n,\tO\nthe\tT-0\namount\tT-0\nand\tT-0\ndistribution\tT-0\nof\tO\nGLEPP1\tO\nprotein\tO\nand\tO\nmRNA\tO\nwere\tO\nexamined\tO\nby\tO\nimmunohistochemistry\tO\n,\tO\nWestern\tO\nblot\tO\nand\tO\nRNase\tO\nprotection\tO\nassay\tO\nin\tO\na\tO\nmodel\tO\nof\tO\npodocyte\tO\ninjury\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nPuromycin\tB-Chemical\naminonucleoside\tI-Chemical\nnephrosis\tO\nwas\tT-1\ninduced\tT-1\nby\tT-1\nsingle\tO\nintraperitoneal\tT-0\ninjection\tT-0\nof\tT-0\npuromycin\tO\naminonucleoside\tO\n(\tO\nPAN\tO\n,\tO\n20\tO\nmg\tO\n/\tO\n100g\tO\nBW\tO\n)\tO\n.\tO\n\nPuromycin\tO\naminonucleoside\tO\nnephrosis\tB-Disease\nwas\tT-0\ninduced\tT-0\nby\tO\nsingle\tO\nintraperitoneal\tO\ninjection\tO\nof\tO\npuromycin\tO\naminonucleoside\tO\n(\tO\nPAN\tO\n,\tO\n20\tO\nmg\tO\n/\tO\n100g\tO\nBW\tO\n)\tO\n.\tO\n\nPuromycin\tO\naminonucleoside\tO\nnephrosis\tO\nwas\tO\ninduced\tO\nby\tO\nsingle\tO\nintraperitoneal\tO\ninjection\tT-1\nof\tT-1\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tO\n,\tO\n20\tO\nmg\tO\n/\tO\n100g\tO\nBW\tO\n)\tO\n.\tO\n\nPuromycin\tO\naminonucleoside\tO\nnephrosis\tO\nwas\tO\ninduced\tO\nby\tO\nsingle\tO\nintraperitoneal\tO\ninjection\tT-0\nof\tT-0\npuromycin\tO\naminonucleoside\tO\n(\tO\nPAN\tB-Chemical\n,\tO\n20\tO\nmg\tO\n/\tO\n100g\tO\nBW\tO\n)\tO\n.\tO\n\nTissues\tO\nwere\tO\nanalyzed\tT-0\nat\tT-0\n0\tO\n,\tO\n5\tO\n,\tO\n7\tO\n,\tO\n11\tO\n,\tO\n21\tO\n,\tO\n45\tO\n,\tO\n80\tO\nand\tT-3\n126\tT-3\ndays\tT-3\nafter\tT-3\nPAN\tB-Chemical\ninjection\tT-4\nso\tO\nas\tO\nto\tT-2\ninclude\tT-2\nboth\tO\nthe\tO\nacute\tO\nphase\tO\nof\tO\nproteinuria\tO\nassociated\tO\nwith\tO\nfoot\tO\nprocess\tO\neffacement\tO\n(\tO\ndays\tO\n5\tO\n-\tO\n11\tO\n)\tO\nand\tO\nthe\tO\nchronic\tO\nphase\tO\nof\tO\nproteinuria\tO\nassociated\tO\nwith\tO\nglomerulosclerosis\tO\n(\tO\ndays\tO\n45\tO\n-\tO\n126\tO\n)\tO\n.\tO\n\nTissues\tO\nwere\tO\nanalyzed\tO\nat\tO\n0\tO\n,\tO\n5\tO\n,\tO\n7\tO\n,\tO\n11\tO\n,\tO\n21\tO\n,\tO\n45\tO\n,\tO\n80\tO\nand\tO\n126\tO\ndays\tO\nafter\tO\nPAN\tO\ninjection\tO\nso\tO\nas\tO\nto\tO\ninclude\tO\nboth\tO\nthe\tO\nacute\tO\nphase\tT-0\nof\tT-0\nproteinuria\tB-Disease\nassociated\tO\nwith\tO\nfoot\tO\nprocess\tO\neffacement\tO\n(\tO\ndays\tO\n5\tO\n-\tO\n11\tO\n)\tO\nand\tO\nthe\tO\nchronic\tO\nphase\tO\nof\tO\nproteinuria\tO\nassociated\tO\nwith\tO\nglomerulosclerosis\tO\n(\tO\ndays\tO\n45\tO\n-\tO\n126\tO\n)\tO\n.\tO\n\nTissues\tO\nwere\tO\nanalyzed\tO\nat\tO\n0\tO\n,\tO\n5\tO\n,\tO\n7\tO\n,\tO\n11\tO\n,\tO\n21\tO\n,\tO\n45\tO\n,\tO\n80\tO\nand\tO\n126\tO\ndays\tO\nafter\tO\nPAN\tO\ninjection\tO\nso\tO\nas\tO\nto\tO\ninclude\tO\nboth\tO\nthe\tO\nacute\tT-0\nphase\tT-0\nof\tO\nproteinuria\tO\nassociated\tO\nwith\tO\nfoot\tO\nprocess\tO\neffacement\tO\n(\tO\ndays\tO\n5\tO\n-\tO\n11\tO\n)\tO\nand\tO\nthe\tO\nchronic\tT-1\nphase\tT-1\nof\tO\nproteinuria\tB-Disease\nassociated\tT-2\nwith\tO\nglomerulosclerosis\tO\n(\tO\ndays\tO\n45\tO\n-\tO\n126\tO\n)\tO\n.\tO\n\nTissues\tO\nwere\tO\nanalyzed\tO\nat\tO\n0\tO\n,\tO\n5\tO\n,\tO\n7\tO\n,\tO\n11\tO\n,\tO\n21\tO\n,\tO\n45\tO\n,\tO\n80\tO\nand\tO\n126\tO\ndays\tO\nafter\tO\nPAN\tO\ninjection\tO\nso\tO\nas\tO\nto\tO\ninclude\tO\nboth\tO\nthe\tO\nacute\tO\nphase\tO\nof\tO\nproteinuria\tO\nassociated\tO\nwith\tO\nfoot\tO\nprocess\tO\neffacement\tO\n(\tO\ndays\tO\n5\tO\n-\tO\n11\tO\n)\tO\nand\tO\nthe\tO\nchronic\tO\nphase\tO\nof\tO\nproteinuria\tO\nassociated\tT-0\nwith\tT-0\nglomerulosclerosis\tB-Disease\n(\tO\ndays\tO\n45\tO\n-\tO\n126\tO\n)\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\nGLEPP1\tO\nexpression\tO\n,\tO\nunlike\tO\npodocalyxin\tO\n,\tO\nreflects\tO\npodocyte\tO\ninjury\tO\ninduced\tT-1\nby\tT-1\nPAN\tB-Chemical\n.\tO\n\nAntithymocyte\tB-Chemical\nglobulin\tI-Chemical\nin\tT-0\nthe\tT-0\ntreatment\tT-0\nof\tT-0\nD\tO\n-\tO\npenicillamine\tO\n-\tO\ninduced\tO\naplastic\tO\nanemia\tO\n.\tO\n\nAntithymocyte\tO\nglobulin\tO\nin\tO\nthe\tO\ntreatment\tT-0\nof\tT-0\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n-\tO\ninduced\tT-2\naplastic\tO\nanemia\tO\n.\tO\n\nAntithymocyte\tO\nglobulin\tO\nin\tO\nthe\tO\ntreatment\tT-0\nof\tT-0\nD\tO\n-\tO\npenicillamine\tO\n-\tO\ninduced\tO\naplastic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nA\tO\npatient\tT-0\nwho\tO\nreceived\tT-1\nantithymocyte\tB-Chemical\nglobulin\tI-Chemical\ntherapy\tO\nfor\tO\naplastic\tO\nanemia\tO\ndue\tO\nto\tO\nD\tO\n-\tO\npenicillamine\tO\ntherapy\tO\nis\tO\ndescribed\tO\n.\tO\n\nA\tT-0\npatient\tT-0\nwho\tO\nreceived\tT-3\nantithymocyte\tT-3\nglobulin\tT-3\ntherapy\tT-3\nfor\tT-1\naplastic\tB-Disease\nanemia\tI-Disease\ndue\tT-4\nto\tT-4\nD\tT-4\n-\tT-4\npenicillamine\tT-4\ntherapy\tT-4\nis\tO\ndescribed\tO\n.\tO\n\nA\tO\npatient\tO\nwho\tO\nreceived\tO\nantithymocyte\tO\nglobulin\tO\ntherapy\tO\nfor\tO\naplastic\tO\nanemia\tO\ndue\tT-1\nto\tT-1\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\ntherapy\tT-0\nis\tO\ndescribed\tO\n.\tO\n\nUse\tT-0\nof\tT-0\nantithymocyte\tB-Chemical\nglobulin\tI-Chemical\nmay\tO\nbe\tO\nthe\tO\noptimal\tO\ntreatment\tO\nof\tO\nD\tO\n-\tO\npenicillamine\tO\n-\tO\ninduced\tT-1\naplastic\tO\nanemia\tO\n.\tO\n\nUse\tO\nof\tO\nantithymocyte\tO\nglobulin\tO\nmay\tO\nbe\tO\nthe\tO\noptimal\tO\ntreatment\tT-0\nof\tT-0\nD\tB-Chemical\n-\tI-Chemical\npenicillamine\tI-Chemical\n-\tO\ninduced\tT-1\naplastic\tO\nanemia\tO\n.\tO\n\nUse\tO\nof\tO\nantithymocyte\tO\nglobulin\tO\nmay\tO\nbe\tO\nthe\tO\noptimal\tO\ntreatment\tO\nof\tO\nD\tO\n-\tO\npenicillamine\tO\n-\tO\ninduced\tT-1\naplastic\tB-Disease\nanemia\tI-Disease\n.\tO\n\nMetamizol\tB-Chemical\npotentiates\tT-0\nmorphine\tO\nantinociception\tO\nbut\tO\nnot\tO\nconstipation\tO\nafter\tT-1\nchronic\tT-1\ntreatment\tT-1\n.\tO\n\nMetamizol\tO\npotentiates\tT-0\nmorphine\tB-Chemical\nantinociception\tO\nbut\tO\nnot\tO\nconstipation\tO\nafter\tO\nchronic\tO\ntreatment\tO\n.\tO\n\nMetamizol\tT-3\npotentiates\tT-3\nmorphine\tT-3\nantinociception\tT-3\nbut\tT-2\nnot\tT-2\nconstipation\tB-Disease\nafter\tO\nchronic\tT-1\ntreatment\tT-1\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\nantinociceptive\tT-0\nand\tO\nconstipating\tB-Disease\neffects\tT-2\nof\tT-2\nthe\tO\ncombination\tO\nof\tO\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nmorphine\tO\nwith\tO\n177\tO\n.\tO\n8\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nmetamizol\tO\nin\tO\nacutely\tO\nand\tO\nchronically\tO\ntreated\tO\n(\tO\nonce\tO\na\tO\nday\tO\nfor\tO\n12\tO\ndays\tO\n)\tO\nrats\tO\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\nantinociceptive\tO\nand\tO\nconstipating\tT-0\neffects\tT-0\nof\tO\nthe\tO\ncombination\tT-1\nof\tT-1\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nmorphine\tB-Chemical\nwith\tO\n177\tO\n.\tO\n8\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nmetamizol\tO\nin\tO\nacutely\tO\nand\tO\nchronically\tO\ntreated\tO\n(\tO\nonce\tO\na\tO\nday\tO\nfor\tO\n12\tO\ndays\tO\n)\tO\nrats\tO\n.\tO\n\nThis\tO\nwork\tO\nevaluates\tO\nthe\tO\nantinociceptive\tO\nand\tO\nconstipating\tO\neffects\tO\nof\tO\nthe\tO\ncombination\tT-2\nof\tT-2\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\ns\tO\n.\tO\nc\tO\n.\tO\nmorphine\tO\nwith\tO\n177\tO\n.\tO\n8\tT-0\nmg\tT-0\n/\tT-0\nkg\tT-0\ns\tT-0\n.\tT-0\nc\tT-0\n.\tT-0\nmetamizol\tB-Chemical\nin\tT-1\nacutely\tT-1\nand\tO\nchronically\tO\ntreated\tO\n(\tO\nonce\tO\na\tO\nday\tO\nfor\tO\n12\tO\ndays\tO\n)\tO\nrats\tO\n.\tO\n\nOn\tO\nthe\tO\n13th\tO\nday\tO\n,\tO\nantinociceptive\tO\neffects\tO\nwere\tO\nassessed\tO\nusing\tO\na\tO\nmodel\tO\nof\tO\ninflammatory\tO\nnociception\tO\n,\tO\npain\tB-Disease\n-\tO\ninduced\tT-0\nfunctional\tO\nimpairment\tO\nmodel\tO\n,\tO\nand\tO\nthe\tO\ncharcoal\tO\nmeal\tO\ntest\tO\nwas\tO\nused\tO\nto\tO\nevaluate\tO\nthe\tO\nintestinal\tO\ntransit\tO\n.\tO\n\nOn\tO\nthe\tO\n13th\tO\nday\tO\n,\tO\nantinociceptive\tO\neffects\tO\nwere\tO\nassessed\tO\nusing\tO\na\tO\nmodel\tO\nof\tO\ninflammatory\tO\nnociception\tO\n,\tO\npain\tO\n-\tO\ninduced\tO\nfunctional\tO\nimpairment\tO\nmodel\tO\n,\tO\nand\tT-0\nthe\tT-0\ncharcoal\tB-Chemical\nmeal\tO\ntest\tT-1\nwas\tO\nused\tO\nto\tO\nevaluate\tO\nthe\tO\nintestinal\tO\ntransit\tO\n.\tO\n\nSimultaneous\tO\nadministration\tT-0\nof\tT-0\nmorphine\tB-Chemical\nwith\tO\nmetamizol\tO\nresulted\tO\nin\tO\na\tO\nmarkedly\tO\nantinociceptive\tO\npotentiation\tO\nand\tO\nan\tO\nincreasing\tO\nof\tO\nthe\tO\nduration\tO\nof\tO\naction\tO\nafter\tO\na\tO\nsingle\tO\n(\tO\n298\tO\n+\tO\n/\tO\n-\tO\n7\tO\nvs\tO\n.\tO\n139\tO\n+\tO\n/\tO\n-\tO\n36\tO\nunits\tO\narea\tO\n(\tO\nua\tO\n)\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\nrepeated\tO\nadministration\tO\n(\tO\n280\tO\n+\tO\n/\tO\n-\tO\n17\tO\nvs\tO\n.\tO\n131\tO\n+\tO\n/\tO\n-\tO\n22\tO\nua\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nSimultaneous\tO\nadministration\tT-0\nof\tT-0\nmorphine\tO\nwith\tO\nmetamizol\tB-Chemical\nresulted\tO\nin\tO\na\tO\nmarkedly\tO\nantinociceptive\tO\npotentiation\tO\nand\tO\nan\tO\nincreasing\tO\nof\tO\nthe\tO\nduration\tT-1\nof\tT-1\naction\tT-1\nafter\tO\na\tO\nsingle\tO\n(\tO\n298\tO\n+\tO\n/\tO\n-\tO\n7\tO\nvs\tO\n.\tO\n139\tO\n+\tO\n/\tO\n-\tO\n36\tO\nunits\tO\narea\tO\n(\tO\nua\tO\n)\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\nand\tO\nrepeated\tT-2\nadministration\tT-2\n(\tO\n280\tO\n+\tO\n/\tO\n-\tO\n17\tO\nvs\tO\n.\tO\n131\tO\n+\tO\n/\tO\n-\tO\n22\tO\nua\tO\n;\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nAntinociceptive\tO\neffect\tT-0\nof\tT-0\nmorphine\tB-Chemical\nwas\tO\nreduced\tO\nin\tO\nchronically\tT-1\ntreated\tT-1\nrats\tO\n(\tO\n39\tO\n+\tO\n/\tO\n-\tO\n10\tO\nvs\tO\n.\tO\n18\tO\n+\tO\n/\tO\n-\tO\n5\tO\nau\tO\n)\tO\nwhile\tO\nthe\tO\ncombination\tO\n-\tO\ninduced\tO\nantinociception\tO\nwas\tO\nremained\tO\nsimilar\tO\nas\tO\nan\tO\nacute\tO\ntreatment\tO\n(\tO\n298\tO\n+\tO\n/\tO\n-\tO\n7\tO\nvs\tO\n.\tO\n280\tO\n+\tO\n/\tO\n-\tO\n17\tO\nau\tO\n)\tO\n.\tO\n\nAcute\tO\nantinociceptive\tO\neffects\tO\nof\tO\nthe\tO\ncombination\tO\nwere\tO\npartially\tO\nprevented\tT-0\nby\tT-0\n3\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nnaloxone\tB-Chemical\ns\tO\n.\tO\nc\tO\n.\tO\n\nIn\tO\nindependent\tT-0\ngroups\tT-0\n,\tO\nmorphine\tB-Chemical\ninhibited\tO\nthe\tO\nintestinal\tO\ntransit\tO\nin\tO\n48\tO\n+\tO\n/\tO\n-\tO\n4\tO\n%\tO\nand\tO\n38\tO\n+\tO\n/\tO\n-\tO\n4\tO\n%\tO\nafter\tO\nacute\tO\nand\tO\nchronic\tO\ntreatment\tO\n,\tO\nrespectively\tO\n,\tO\nsuggesting\tO\nthat\tO\ntolerance\tO\ndid\tO\nnot\tO\ndevelop\tO\nto\tO\nthe\tO\nconstipating\tO\neffects\tO\n.\tO\n\nIn\tO\nindependent\tO\ngroups\tO\n,\tO\nmorphine\tO\ninhibited\tO\nthe\tO\nintestinal\tO\ntransit\tO\nin\tO\n48\tO\n+\tO\n/\tO\n-\tO\n4\tO\n%\tO\nand\tO\n38\tO\n+\tO\n/\tO\n-\tO\n4\tO\n%\tO\nafter\tO\nacute\tO\nand\tO\nchronic\tO\ntreatment\tO\n,\tO\nrespectively\tO\n,\tO\nsuggesting\tO\nthat\tO\ntolerance\tT-0\ndid\tO\nnot\tO\ndevelop\tO\nto\tO\nthe\tO\nconstipating\tB-Disease\neffects\tT-1\n.\tO\n\nThe\tO\ncombination\tO\ninhibited\tO\nintestinal\tO\ntransit\tO\nsimilar\tO\nto\tO\nthat\tO\nproduced\tT-0\nby\tT-0\nmorphine\tB-Chemical\nregardless\tT-1\nof\tT-1\nthe\tT-1\ntime\tT-1\nof\tT-1\ntreatment\tT-1\n,\tO\nsuggesting\tO\nthat\tO\nmetamizol\tO\ndid\tO\nnot\tO\npotentiate\tO\nmorphine\tO\n-\tO\ninduced\tO\nconstipation\tO\n.\tO\n\nThe\tO\ncombination\tO\ninhibited\tO\nintestinal\tO\ntransit\tO\nsimilar\tO\nto\tO\nthat\tO\nproduced\tO\nby\tO\nmorphine\tT-0\nregardless\tO\nof\tO\nthe\tO\ntime\tO\nof\tO\ntreatment\tO\n,\tO\nsuggesting\tT-2\nthat\tT-2\nmetamizol\tB-Chemical\ndid\tT-3\nnot\tT-3\npotentiate\tT-3\nmorphine\tT-3\n-\tO\ninduced\tO\nconstipation\tO\n.\tO\n\nThe\tO\ncombination\tO\ninhibited\tO\nintestinal\tO\ntransit\tO\nsimilar\tO\nto\tO\nthat\tO\nproduced\tO\nby\tO\nmorphine\tO\nregardless\tO\nof\tO\nthe\tO\ntime\tO\nof\tO\ntreatment\tO\n,\tO\nsuggesting\tO\nthat\tO\nmetamizol\tO\ndid\tO\nnot\tO\npotentiate\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tT-0\nconstipation\tT-0\n.\tO\n\nThe\tO\ncombination\tO\ninhibited\tO\nintestinal\tO\ntransit\tO\nsimilar\tO\nto\tO\nthat\tO\nproduced\tO\nby\tO\nmorphine\tO\nregardless\tO\nof\tO\nthe\tO\ntime\tO\nof\tO\ntreatment\tO\n,\tO\nsuggesting\tO\nthat\tO\nmetamizol\tO\ndid\tO\nnot\tO\npotentiate\tO\nmorphine\tT-1\n-\tT-1\ninduced\tT-1\nconstipation\tB-Disease\n.\tO\n\nThese\tO\nfindings\tO\nshow\tO\na\tO\nsignificant\tO\ninteraction\tT-0\nbetween\tT-1\nmorphine\tB-Chemical\nand\tT-2\nmetamizol\tO\nin\tO\nchronically\tO\ntreated\tO\nrats\tO\n,\tO\nsuggesting\tO\nthat\tO\nthis\tO\ncombination\tO\ncould\tO\nbe\tO\nuseful\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nchronic\tO\npain\tO\n.\tO\n\nThese\tO\nfindings\tO\nshow\tO\na\tO\nsignificant\tO\ninteraction\tO\nbetween\tO\nmorphine\tT-1\nand\tT-1\nmetamizol\tB-Chemical\nin\tT-2\nchronically\tT-2\ntreated\tT-2\nrats\tT-2\n,\tO\nsuggesting\tO\nthat\tO\nthis\tO\ncombination\tO\ncould\tO\nbe\tO\nuseful\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nchronic\tO\npain\tO\n.\tO\n\nThese\tO\nfindings\tO\nshow\tO\na\tO\nsignificant\tO\ninteraction\tO\nbetween\tO\nmorphine\tO\nand\tO\nmetamizol\tO\nin\tO\nchronically\tO\ntreated\tO\nrats\tO\n,\tO\nsuggesting\tO\nthat\tO\nthis\tO\ncombination\tO\ncould\tO\nbe\tO\nuseful\tO\nfor\tO\nthe\tO\ntreatment\tT-0\nof\tO\nchronic\tB-Disease\npain\tI-Disease\n.\tO\n\nIfosfamide\tB-Chemical\nencephalopathy\tO\npresenting\tT-0\nwith\tO\nasterixis\tO\n.\tO\n\nIfosfamide\tT-0\nencephalopathy\tB-Disease\npresenting\tT-1\nwith\tO\nasterixis\tO\n.\tO\n\nIfosfamide\tT-0\nencephalopathy\tT-0\npresenting\tT-1\nwith\tT-1\nasterixis\tB-Disease\n.\tO\n\nCNS\tO\ntoxic\tT-0\neffects\tT-0\nof\tO\nthe\tO\nantineoplastic\tO\nagent\tT-2\nifosfamide\tB-Chemical\n(\tO\nIFX\tO\n)\tO\nare\tT-3\nfrequent\tT-3\nand\tO\ninclude\tO\na\tO\nvariety\tO\nof\tO\nneurological\tO\nsymptoms\tO\nthat\tO\ncan\tO\nlimit\tT-1\ndrug\tT-1\nuse\tT-1\n.\tO\n\nCNS\tO\ntoxic\tT-0\neffects\tT-0\nof\tO\nthe\tO\nantineoplastic\tO\nagent\tO\nifosfamide\tO\n(\tO\nIFX\tB-Chemical\n)\tO\nare\tO\nfrequent\tO\nand\tO\ninclude\tO\na\tO\nvariety\tO\nof\tO\nneurological\tO\nsymptoms\tO\nthat\tO\ncan\tO\nlimit\tO\ndrug\tO\nuse\tO\n.\tO\n\nWe\tO\nreport\tO\na\tT-1\ncase\tT-1\nof\tO\na\tO\n51\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\ndeveloped\tT-2\nsevere\tO\n,\tO\ndisabling\tO\nnegative\tO\nmyoclonus\tB-Disease\nof\tO\nthe\tO\nupper\tO\nand\tO\nlower\tO\nextremities\tO\nafter\tO\nthe\tO\ninfusion\tO\nof\tO\nifosfamide\tO\nfor\tO\nplasmacytoma\tO\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\n51\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\ndeveloped\tO\nsevere\tO\n,\tO\ndisabling\tO\nnegative\tO\nmyoclonus\tO\nof\tO\nthe\tO\nupper\tO\nand\tO\nlower\tO\nextremities\tO\nafter\tO\nthe\tO\ninfusion\tT-1\nof\tO\nifosfamide\tB-Chemical\nfor\tT-0\nplasmacytoma\tT-0\n.\tO\n\nWe\tO\nreport\tO\na\tO\ncase\tO\nof\tO\na\tO\n51\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nwho\tO\ndeveloped\tO\nsevere\tO\n,\tO\ndisabling\tO\nnegative\tO\nmyoclonus\tO\nof\tO\nthe\tO\nupper\tO\nand\tO\nlower\tO\nextremities\tO\nafter\tO\nthe\tO\ninfusion\tT-1\nof\tT-1\nifosfamide\tT-0\nfor\tT-0\nplasmacytoma\tB-Disease\n.\tO\n\nCranial\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nextensive\tO\nlaboratory\tO\nstudies\tO\nfailed\tO\nto\tO\nreveal\tT-1\nstructural\tB-Disease\nlesions\tI-Disease\nof\tI-Disease\nthe\tI-Disease\nbrain\tI-Disease\nand\tO\nmetabolic\tT-0\nabnormalities\tT-0\n.\tO\n\nCranial\tO\nmagnetic\tO\nresonance\tO\nimaging\tO\nand\tO\nextensive\tO\nlaboratory\tO\nstudies\tT-0\nfailed\tT-0\nto\tT-0\nreveal\tT-0\nstructural\tO\nlesions\tO\nof\tO\nthe\tO\nbrain\tO\nand\tO\nmetabolic\tB-Disease\nabnormalities\tI-Disease\n.\tO\n\nAn\tO\nelectroencephalogram\tO\nshowed\tO\ncontinuous\tO\n,\tO\ngeneralized\tO\nirregular\tO\nslowing\tO\nwith\tO\nadmixed\tO\nperiodic\tO\ntriphasic\tO\nwaves\tO\nindicating\tO\nsymptomatic\tT-0\nencephalopathy\tB-Disease\n.\tO\n\nThe\tT-0\nadministration\tT-0\nof\tT-0\nifosfamide\tB-Chemical\nwas\tO\ndiscontinued\tO\nand\tO\nwithin\tO\n12\tO\nh\tO\nthe\tO\nasterixis\tO\nresolved\tO\ncompletely\tO\n.\tO\n\nThe\tO\nadministration\tO\nof\tO\nifosfamide\tO\nwas\tO\ndiscontinued\tO\nand\tO\nwithin\tO\n12\tO\nh\tO\nthe\tT-0\nasterixis\tB-Disease\nresolved\tT-1\ncompletely\tO\n.\tO\n\nIn\tO\nthe\tO\npatient\tO\ndescribed\tO\n,\tO\nthe\tO\npresence\tT-1\nof\tT-1\nasterixis\tB-Disease\nduring\tT-0\ninfusion\tT-0\nof\tT-0\nifosfamide\tT-0\n,\tO\nnormal\tO\nlaboratory\tO\nfindings\tO\nand\tO\nimaging\tO\nstudies\tO\nand\tO\nthe\tO\nresolution\tO\nof\tO\nsymptoms\tO\nfollowing\tO\nthe\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nsuggest\tO\nthat\tO\nnegative\tO\nmyoclonus\tO\nis\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nIFX\tO\n.\tO\n\nIn\tO\nthe\tO\npatient\tO\ndescribed\tO\n,\tO\nthe\tO\npresence\tO\nof\tO\nasterixis\tO\nduring\tO\ninfusion\tT-0\nof\tO\nifosfamide\tB-Chemical\n,\tO\nnormal\tO\nlaboratory\tO\nfindings\tT-1\nand\tO\nimaging\tO\nstudies\tT-2\nand\tO\nthe\tO\nresolution\tO\nof\tO\nsymptoms\tO\nfollowing\tO\nthe\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nsuggest\tO\nthat\tO\nnegative\tO\nmyoclonus\tO\nis\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nIFX\tO\n.\tO\n\nIn\tO\nthe\tO\npatient\tO\ndescribed\tO\n,\tO\nthe\tO\npresence\tO\nof\tO\nasterixis\tO\nduring\tO\ninfusion\tO\nof\tO\nifosfamide\tO\n,\tO\nnormal\tO\nlaboratory\tO\nfindings\tO\nand\tO\nimaging\tO\nstudies\tO\nand\tO\nthe\tO\nresolution\tO\nof\tO\nsymptoms\tO\nfollowing\tO\nthe\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nsuggest\tO\nthat\tO\nnegative\tT-1\nmyoclonus\tB-Disease\nis\tT-0\nassociated\tT-0\nwith\tO\nthe\tO\nuse\tO\nof\tO\nIFX\tO\n.\tO\n\nIn\tO\nthe\tO\npatient\tO\ndescribed\tO\n,\tO\nthe\tO\npresence\tO\nof\tO\nasterixis\tO\nduring\tO\ninfusion\tO\nof\tO\nifosfamide\tO\n,\tO\nnormal\tO\nlaboratory\tO\nfindings\tO\nand\tO\nimaging\tO\nstudies\tO\nand\tO\nthe\tO\nresolution\tO\nof\tO\nsymptoms\tO\nfollowing\tO\nthe\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\nsuggest\tO\nthat\tO\nnegative\tO\nmyoclonus\tO\nis\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tT-0\nof\tT-0\nIFX\tB-Chemical\n.\tO\n\nAntagonism\tO\nbetween\tO\ninterleukin\tO\n3\tO\nand\tO\nerythropoietin\tO\nin\tO\nmice\tT-0\nwith\tT-0\nazidothymidine\tB-Chemical\n-\tO\ninduced\tT-1\nanemia\tO\nand\tO\nin\tO\nbone\tO\nmarrow\tO\nendothelial\tO\ncells\tO\n.\tO\n\nAntagonism\tT-0\nbetween\tO\ninterleukin\tO\n3\tO\nand\tO\nerythropoietin\tO\nin\tO\nmice\tO\nwith\tO\nazidothymidine\tO\n-\tO\ninduced\tO\nanemia\tB-Disease\nand\tO\nin\tO\nbone\tT-1\nmarrow\tT-1\nendothelial\tT-1\ncells\tT-1\n.\tO\n\nAzidothymidine\tB-Chemical\n(\tO\nAZT\tO\n)\tO\n-\tO\ninduced\tT-1\nanemia\tO\nin\tO\nmice\tO\ncan\tO\nbe\tO\nreversed\tO\nby\tO\nthe\tO\nadministration\tO\nof\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\n(\tO\nfusion\tO\nprotein\tO\nof\tO\ninsulin\tO\n-\tO\nlike\tO\ngrowth\tO\nfactor\tO\nII\tO\n(\tO\nIGF\tO\nII\tO\n)\tO\nand\tO\ninterleukin\tO\n3\tO\n)\tO\n.\tO\n\nAzidothymidine\tO\n(\tO\nAZT\tB-Chemical\n)\tO\n-\tO\ninduced\tT-0\nanemia\tO\nin\tO\nmice\tO\ncan\tO\nbe\tO\nreversed\tO\nby\tO\nthe\tO\nadministration\tO\nof\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\n(\tO\nfusion\tO\nprotein\tO\nof\tO\ninsulin\tO\n-\tO\nlike\tO\ngrowth\tO\nfactor\tO\nII\tO\n(\tO\nIGF\tO\nII\tO\n)\tO\nand\tO\ninterleukin\tO\n3\tO\n)\tO\n.\tO\n\nAzidothymidine\tO\n(\tT-0\nAZT\tT-0\n)\tT-0\n-\tT-0\ninduced\tT-0\nanemia\tB-Disease\nin\tO\nmice\tO\ncan\tT-1\nbe\tT-1\nreversed\tT-1\nby\tO\nthe\tO\nadministration\tO\nof\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\n(\tO\nfusion\tO\nprotein\tO\nof\tO\ninsulin\tO\n-\tO\nlike\tO\ngrowth\tO\nfactor\tO\nII\tO\n(\tO\nIGF\tO\nII\tO\n)\tO\nand\tO\ninterleukin\tO\n3\tO\n)\tO\n.\tO\n\nAlthough\tO\ninterleukin\tO\n3\tO\n(\tO\nIL\tO\n-\tO\n3\tO\n)\tO\nand\tO\nerythropoietin\tO\n(\tO\nEPO\tO\n)\tO\nare\tO\nknown\tO\nto\tO\nact\tO\nsynergistically\tO\non\tO\nhematopoietic\tO\ncell\tO\nproliferation\tO\nin\tO\nvitro\tO\n,\tO\ninjection\tT-1\nof\tT-1\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\nand\tO\nEPO\tO\nin\tT-0\nAZT\tB-Chemical\n-\tO\ntreated\tT-2\nmice\tT-2\nresulted\tO\nin\tO\na\tO\nreduction\tO\nof\tO\nred\tO\ncells\tO\nand\tO\nan\tO\nincrease\tO\nof\tO\nplasma\tO\nEPO\tO\nlevels\tO\nas\tO\ncompared\tO\nto\tO\nanimals\tO\ntreated\tO\nwith\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\nor\tO\nEPO\tO\nalone\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nsignificant\tO\nreduction\tT-1\nof\tT-1\nthymidine\tB-Chemical\nincorporation\tT-2\ninto\tT-2\nboth\tO\nerythroid\tO\nand\tO\nendothelial\tO\ncells\tO\nin\tO\ncultures\tO\npre\tO\n-\tO\ntreated\tO\nwith\tO\nIGF\tO\n-\tO\nIL\tO\n-\tO\n3\tO\nand\tO\nEPO\tO\n.\tO\n\nEndothelial\tO\ncell\tO\nculture\tO\nsupernatants\tO\nseparated\tO\nby\tO\nultrafiltration\tO\nand\tO\nultracentrifugation\tO\nfrom\tO\ncells\tO\ntreated\tO\nwith\tO\nEPO\tO\nand\tO\nIL\tO\n-\tO\n3\tO\nsignificantly\tT-0\nreduced\tT-0\nthymidine\tB-Chemical\nincorporation\tO\ninto\tO\nerythroid\tO\ncells\tO\nas\tO\ncompared\tO\nto\tO\nidentical\tO\nfractions\tO\nobtained\tO\nfrom\tO\nthe\tO\nmedia\tO\nof\tO\ncells\tO\ncultured\tO\nwith\tO\nEPO\tO\nalone\tO\n.\tO\n\nThe\tO\nrelationship\tO\nbetween\tO\nhippocampal\tO\nacetylcholine\tO\nrelease\tO\nand\tO\ncholinergic\tO\nconvulsant\tO\nsensitivity\tO\nin\tT-0\nwithdrawal\tT-0\nseizure\tB-Disease\n-\tO\nprone\tT-1\nand\tT-1\nwithdrawal\tT-1\nseizure\tT-1\n-\tO\nresistant\tO\nselected\tO\nmouse\tO\nlines\tO\n.\tO\n\nThe\tO\nrelationship\tO\nbetween\tO\nhippocampal\tO\nacetylcholine\tO\nrelease\tO\nand\tO\ncholinergic\tO\nconvulsant\tO\nsensitivity\tO\nin\tO\nwithdrawal\tO\nseizure\tO\n-\tO\nprone\tO\nand\tO\nwithdrawal\tT-0\nseizure\tB-Disease\n-\tO\nresistant\tT-1\nselected\tT-1\nmouse\tT-1\nlines\tT-1\n.\tO\n\nBACKGROUND\tO\n:\tO\nThe\tO\nsepto\tO\n-\tO\nhippocampal\tO\ncholinergic\tO\npathway\tO\nhas\tO\nbeen\tO\nimplicated\tO\nin\tO\nepileptogenesis\tO\n,\tO\nand\tO\ngenetic\tO\nfactors\tO\ninfluence\tO\nthe\tO\nresponse\tO\nto\tO\ncholinergic\tO\nagents\tO\n,\tO\nbut\tO\nlimited\tO\ndata\tO\nare\tO\navailable\tO\non\tO\ncholinergic\tO\ninvolvement\tO\nin\tT-1\nalcohol\tB-Chemical\nwithdrawal\tT-2\nseverity\tT-2\n.\tT-1\n\nThus\tO\n,\tO\nthe\tO\nrelationship\tO\nbetween\tO\ncholinergic\tO\nactivity\tO\nand\tO\nresponsiveness\tO\nand\tO\nalcohol\tB-Chemical\nwithdrawal\tT-0\nwas\tO\ninvestigated\tO\nin\tO\na\tO\ngenetic\tO\nanimal\tO\nmodel\tO\nof\tO\nethanol\tO\nwithdrawal\tO\nseverity\tO\n.\tO\n\nThus\tO\n,\tO\nthe\tO\nrelationship\tO\nbetween\tO\ncholinergic\tT-0\nactivity\tT-0\nand\tO\nresponsiveness\tO\nand\tO\nalcohol\tT-1\nwithdrawal\tT-1\nwas\tO\ninvestigated\tO\nin\tO\na\tO\ngenetic\tO\nanimal\tO\nmodel\tT-4\nof\tT-4\nethanol\tB-Chemical\nwithdrawal\tT-3\nseverity\tT-3\n.\tT-3\n\nMETHODS\tO\n:\tO\nCholinergic\tO\nconvulsant\tO\nsensitivity\tO\nwas\tO\nexamined\tT-0\nin\tO\nalcohol\tB-Chemical\n-\tO\nna\tT-1\nve\tT-1\nWithdrawal\tT-1\nSeizure\tT-1\n-\tO\nProne\tO\n(\tO\nWSP\tO\n)\tO\nand\tO\n-\tO\nResistant\tO\n(\tO\nWSR\tO\n)\tO\nmice\tO\n.\tO\n\nMETHODS\tO\n:\tO\nCholinergic\tO\nconvulsant\tO\nsensitivity\tO\nwas\tO\nexamined\tO\nin\tO\nalcohol\tO\n-\tO\nna\tO\nve\tO\nWithdrawal\tT-0\nSeizure\tB-Disease\n-\tO\nProne\tT-1\n(\tT-1\nWSP\tT-1\n)\tT-1\nand\tT-1\n-\tT-1\nResistant\tT-1\n(\tT-1\nWSR\tT-1\n)\tT-1\nmice\tT-1\n.\tO\n\nAnimals\tO\nwere\tO\nadministered\tT-1\nnicotine\tB-Chemical\n,\tO\ncarbachol\tT-2\n,\tO\nor\tO\nneostigmine\tO\nvia\tO\ntimed\tO\ntail\tO\nvein\tO\ninfusion\tO\n,\tO\nand\tO\nthe\tO\nlatencies\tO\nto\tO\nonset\tO\nof\tO\ntremor\tO\nand\tO\nclonus\tO\nwere\tO\nrecorded\tO\nand\tO\nconverted\tO\nto\tO\nthreshold\tO\ndose\tO\n.\tO\n\nAnimals\tO\nwere\tO\nadministered\tT-0\nnicotine\tO\n,\tO\ncarbachol\tB-Chemical\n,\tO\nor\tO\nneostigmine\tO\nvia\tO\ntimed\tO\ntail\tO\nvein\tO\ninfusion\tO\n,\tO\nand\tO\nthe\tO\nlatencies\tO\nto\tO\nonset\tO\nof\tO\ntremor\tO\nand\tO\nclonus\tO\nwere\tO\nrecorded\tO\nand\tO\nconverted\tO\nto\tO\nthreshold\tO\ndose\tO\n.\tO\n\nAnimals\tO\nwere\tO\nadministered\tT-1\nnicotine\tO\n,\tO\ncarbachol\tO\n,\tO\nor\tO\nneostigmine\tB-Chemical\nvia\tT-0\ntimed\tT-0\ntail\tO\nvein\tO\ninfusion\tO\n,\tO\nand\tO\nthe\tO\nlatencies\tO\nto\tO\nonset\tO\nof\tO\ntremor\tO\nand\tO\nclonus\tO\nwere\tO\nrecorded\tO\nand\tO\nconverted\tO\nto\tO\nthreshold\tT-2\ndose\tT-2\n.\tO\n\nAnimals\tO\nwere\tO\nadministered\tO\nnicotine\tO\n,\tO\ncarbachol\tO\n,\tO\nor\tO\nneostigmine\tO\nvia\tO\ntimed\tO\ntail\tO\nvein\tO\ninfusion\tO\n,\tO\nand\tO\nthe\tO\nlatencies\tO\nto\tO\nonset\tT-0\nof\tT-0\ntremor\tB-Disease\nand\tO\nclonus\tO\nwere\tO\nrecorded\tO\nand\tO\nconverted\tO\nto\tO\nthreshold\tO\ndose\tO\n.\tO\n\nWe\tO\nalso\tO\nused\tT-3\nmicrodialysis\tT-0\nto\tO\nmeasure\tO\nbasal\tO\nand\tO\npotassium\tB-Chemical\n-\tO\nstimulated\tT-1\nacetylcholine\tO\n(\tO\nACh\tO\n)\tO\nrelease\tT-2\nin\tO\nthe\tO\nCA1\tO\nregion\tO\nof\tO\nthe\tO\nhippocampus\tO\n.\tO\n\nWe\tO\nalso\tO\nused\tO\nmicrodialysis\tO\nto\tO\nmeasure\tO\nbasal\tO\nand\tO\npotassium\tO\n-\tO\nstimulated\tT-0\nacetylcholine\tB-Chemical\n(\tO\nACh\tO\n)\tO\nrelease\tT-1\nin\tT-1\nthe\tT-1\nCA1\tT-1\nregion\tT-1\nof\tO\nthe\tO\nhippocampus\tO\n.\tO\n\nWe\tO\nalso\tO\nused\tO\nmicrodialysis\tO\nto\tO\nmeasure\tO\nbasal\tO\nand\tO\npotassium\tO\n-\tO\nstimulated\tO\nacetylcholine\tO\n(\tO\nACh\tB-Chemical\n)\tO\nrelease\tT-0\nin\tO\nthe\tO\nCA1\tO\nregion\tO\nof\tO\nthe\tO\nhippocampus\tO\n.\tO\n\nPotassium\tB-Chemical\nwas\tT-0\napplied\tT-1\nby\tO\nreverse\tO\ndialysis\tO\ntwice\tO\n,\tO\nseparated\tO\nby\tO\n75\tO\nmin\tO\n.\tO\n\nHippocampal\tO\nACh\tB-Chemical\nalso\tO\nwas\tT-0\nmeasured\tT-0\nduring\tO\ntesting\tO\nfor\tO\nhandling\tO\n-\tO\ninduced\tO\nconvulsions\tO\n.\tO\n\nHippocampal\tO\nACh\tO\nalso\tO\nwas\tO\nmeasured\tO\nduring\tO\ntesting\tO\nfor\tO\nhandling\tO\n-\tO\ninduced\tT-0\nconvulsions\tB-Disease\n.\tO\n\nRESULTS\tO\n:\tO\nSensitivity\tT-0\nto\tT-0\nseveral\tO\nconvulsion\tB-Disease\nendpoints\tO\ninduced\tT-2\nby\tO\nnicotine\tO\n,\tO\ncarbachol\tO\n,\tO\nand\tO\nneostigmine\tO\nwere\tO\nsignificantly\tO\ngreater\tO\nin\tO\nWSR\tO\nversus\tT-3\nWSP\tO\nmice\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSensitivity\tO\nto\tO\nseveral\tO\nconvulsion\tO\nendpoints\tO\ninduced\tT-0\nby\tO\nnicotine\tB-Chemical\n,\tO\ncarbachol\tO\n,\tO\nand\tO\nneostigmine\tO\nwere\tO\nsignificantly\tO\ngreater\tO\nin\tO\nWSR\tO\nversus\tO\nWSP\tO\nmice\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSensitivity\tO\nto\tO\nseveral\tO\nconvulsion\tO\nendpoints\tO\ninduced\tT-2\nby\tT-2\nnicotine\tT-0\n,\tO\ncarbachol\tB-Chemical\n,\tO\nand\tT-1\nneostigmine\tT-1\nwere\tO\nsignificantly\tO\ngreater\tO\nin\tO\nWSR\tO\nversus\tO\nWSP\tO\nmice\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSensitivity\tO\nto\tO\nseveral\tO\nconvulsion\tO\nendpoints\tO\ninduced\tT-1\nby\tT-1\nnicotine\tO\n,\tO\ncarbachol\tO\n,\tO\nand\tO\nneostigmine\tB-Chemical\nwere\tT-0\nsignificantly\tT-0\ngreater\tO\nin\tO\nWSR\tO\nversus\tO\nWSP\tO\nmice\tO\n.\tO\n\nIn\tO\nmicrodialysis\tO\nexperiments\tO\n,\tO\nthe\tO\nlines\tO\ndid\tO\nnot\tO\ndiffer\tO\nin\tO\nbasal\tT-2\nrelease\tT-2\nof\tT-2\nACh\tB-Chemical\n,\tO\nand\tO\n50\tO\nmM\tO\nKCl\tO\nincreased\tT-0\nACh\tO\noutput\tO\nin\tO\nboth\tO\nlines\tO\nof\tO\nmice\tO\n.\tO\n\nIn\tO\nmicrodialysis\tO\nexperiments\tO\n,\tO\nthe\tO\nlines\tO\ndid\tO\nnot\tO\ndiffer\tO\nin\tO\nbasal\tO\nrelease\tO\nof\tO\nACh\tO\n,\tO\nand\tO\n50\tO\nmM\tO\nKCl\tB-Chemical\nincreased\tT-0\nACh\tO\noutput\tO\nin\tO\nboth\tO\nlines\tO\nof\tO\nmice\tO\n.\tO\n\nIn\tO\nmicrodialysis\tO\nexperiments\tO\n,\tO\nthe\tO\nlines\tO\ndid\tO\nnot\tO\ndiffer\tO\nin\tO\nbasal\tO\nrelease\tO\nof\tO\nACh\tO\n,\tO\nand\tO\n50\tO\nmM\tO\nKCl\tO\nincreased\tT-0\nACh\tB-Chemical\noutput\tT-1\nin\tO\nboth\tO\nlines\tO\nof\tO\nmice\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nincrease\tO\nin\tO\nrelease\tT-0\nof\tT-0\nACh\tB-Chemical\nproduced\tT-1\nby\tT-1\nthe\tO\nfirst\tO\napplication\tO\nof\tO\nKCl\tO\nwas\tO\n2\tO\n-\tO\nfold\tO\nhigher\tO\nin\tO\nWSP\tO\nversus\tO\nWSR\tO\nmice\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nincrease\tO\nin\tO\nrelease\tO\nof\tO\nACh\tO\nproduced\tO\nby\tO\nthe\tO\nfirst\tT-0\napplication\tT-0\nof\tT-0\nKCl\tB-Chemical\nwas\tT-1\n2\tT-1\n-\tO\nfold\tO\nhigher\tO\nin\tO\nWSP\tO\nversus\tO\nWSR\tO\nmice\tO\n.\tO\n\nWhen\tT-0\nhippocampal\tT-0\nACh\tB-Chemical\nwas\tO\nmeasured\tT-1\nduring\tO\ntesting\tO\nfor\tO\nhandling\tO\n-\tO\ninduced\tT-2\nconvulsions\tO\n,\tO\nextracellular\tO\nACh\tO\nwas\tO\nsignificantly\tO\nelevated\tO\n(\tO\n192\tO\n%\tO\n)\tO\nin\tO\nWSP\tO\nmice\tO\n,\tO\nbut\tO\nwas\tO\nnonsignificantly\tO\nelevated\tO\n(\tO\n59\tO\n%\tO\n)\tO\nin\tO\nWSR\tO\nmice\tO\n.\tO\n\nWhen\tO\nhippocampal\tO\nACh\tO\nwas\tO\nmeasured\tO\nduring\tO\ntesting\tO\nfor\tO\nhandling\tO\n-\tO\ninduced\tT-0\nconvulsions\tB-Disease\n,\tO\nextracellular\tO\nACh\tO\nwas\tO\nsignificantly\tO\nelevated\tO\n(\tO\n192\tO\n%\tO\n)\tO\nin\tO\nWSP\tO\nmice\tO\n,\tO\nbut\tO\nwas\tO\nnonsignificantly\tO\nelevated\tO\n(\tO\n59\tO\n%\tO\n)\tO\nin\tO\nWSR\tO\nmice\tO\n.\tO\n\nWhen\tO\nhippocampal\tO\nACh\tO\nwas\tO\nmeasured\tO\nduring\tO\ntesting\tO\nfor\tO\nhandling\tO\n-\tO\ninduced\tO\nconvulsions\tO\n,\tO\nextracellular\tO\nACh\tB-Chemical\nwas\tT-1\nsignificantly\tT-1\nelevated\tT-1\n(\tO\n192\tO\n%\tO\n)\tO\nin\tO\nWSP\tO\nmice\tO\n,\tO\nbut\tO\nwas\tO\nnonsignificantly\tO\nelevated\tO\n(\tO\n59\tO\n%\tO\n)\tO\nin\tO\nWSR\tO\nmice\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\ndifferences\tO\nin\tO\ncholinergic\tO\nactivity\tO\nand\tO\npostsynaptic\tO\nsensitivity\tT-0\nto\tT-0\ncholinergic\tT-0\nconvulsants\tB-Disease\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nethanol\tO\nwithdrawal\tO\nseverity\tO\nand\tO\nimplicate\tO\ncholinergic\tO\nmechanisms\tO\nin\tO\nalcohol\tO\nwithdrawal\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\ndifferences\tO\nin\tO\ncholinergic\tO\nactivity\tO\nand\tO\npostsynaptic\tO\nsensitivity\tO\nto\tO\ncholinergic\tT-0\nconvulsants\tT-0\nmay\tO\nbe\tO\nassociated\tT-1\nwith\tT-1\nethanol\tB-Chemical\nwithdrawal\tT-2\nseverity\tT-2\nand\tO\nimplicate\tO\ncholinergic\tO\nmechanisms\tO\nin\tO\nalcohol\tO\nwithdrawal\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nThese\tO\nresults\tO\nsuggest\tO\nthat\tO\ndifferences\tO\nin\tO\ncholinergic\tO\nactivity\tO\nand\tO\npostsynaptic\tO\nsensitivity\tO\nto\tO\ncholinergic\tO\nconvulsants\tO\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nethanol\tO\nwithdrawal\tO\nseverity\tO\nand\tO\nimplicate\tO\ncholinergic\tT-0\nmechanisms\tT-0\nin\tO\nalcohol\tB-Chemical\nwithdrawal\tO\n.\tO\n\nSpecifically\tO\n,\tO\nWSP\tO\nmice\tO\nmay\tO\nhave\tO\nlower\tO\nsensitivity\tT-0\nto\tO\ncholinergic\tO\nconvulsants\tB-Disease\ncompared\tO\nwith\tO\nWSR\tO\nbecause\tO\nof\tO\npostsynaptic\tO\nreceptor\tO\ndesensitization\tO\nbrought\tO\non\tO\nby\tO\nhigher\tO\nactivity\tO\nof\tO\ncholinergic\tO\nneurons\tO\n.\tO\n\nCapsaicin\tB-Chemical\n-\tO\ninduced\tT-0\nmuscle\tO\npain\tO\nalters\tO\nthe\tO\nexcitability\tO\nof\tO\nthe\tO\nhuman\tO\njaw\tO\n-\tO\nstretch\tO\nreflex\tO\n.\tO\n\nCapsaicin\tT-0\n-\tT-0\ninduced\tT-0\nmuscle\tB-Disease\npain\tI-Disease\nalters\tO\nthe\tO\nexcitability\tO\nof\tO\nthe\tO\nhuman\tO\njaw\tO\n-\tO\nstretch\tO\nreflex\tO\n.\tO\n\nThe\tO\npathophysiology\tO\nof\tT-0\npainful\tT-0\ntemporomandibular\tB-Disease\ndisorders\tI-Disease\nis\tO\nnot\tO\nfully\tO\nunderstood\tO\n,\tO\nbut\tO\nevidence\tO\nsuggests\tO\nthat\tO\nmuscle\tO\npain\tO\nmodulates\tO\nmotor\tO\nfunction\tO\nin\tO\ncharacteristic\tO\nways\tO\n.\tO\n\nThe\tO\npathophysiology\tO\nof\tO\npainful\tO\ntemporomandibular\tT-0\ndisorders\tT-0\nis\tO\nnot\tO\nfully\tO\nunderstood\tO\n,\tO\nbut\tO\nevidence\tO\nsuggests\tO\nthat\tO\nmuscle\tB-Disease\npain\tI-Disease\nmodulates\tT-1\nmotor\tO\nfunction\tO\nin\tO\ncharacteristic\tO\nways\tO\n.\tO\n\nCapsaicin\tB-Chemical\n(\tO\n10\tO\nmicro\tO\ng\tO\n)\tO\nwas\tT-0\ninjected\tT-0\ninto\tO\nthe\tO\nmasseter\tO\nmuscle\tO\nto\tO\ninduce\tO\npain\tO\nin\tO\n11\tO\nhealthy\tO\nvolunteers\tO\n.\tO\n\nCapsaicin\tO\n(\tO\n10\tO\nmicro\tO\ng\tO\n)\tO\nwas\tO\ninjected\tO\ninto\tO\nthe\tO\nmasseter\tO\nmuscle\tO\nto\tT-0\ninduce\tT-0\npain\tB-Disease\nin\tT-1\n11\tT-1\nhealthy\tT-1\nvolunteers\tT-1\n.\tO\n\nShort\tO\n-\tO\nlatency\tO\nreflex\tO\nresponses\tO\nwere\tO\nevoked\tO\nin\tO\nthe\tO\nmasseter\tO\nand\tO\ntemporalis\tO\nmuscles\tO\nby\tO\na\tO\nstretch\tO\ndevice\tO\nwith\tO\ndifferent\tO\nvelocities\tO\nand\tO\ndisplacements\tT-0\nbefore\tT-0\n,\tT-0\nduring\tT-0\n,\tT-0\nand\tT-0\nafter\tT-1\nthe\tT-1\npain\tB-Disease\n.\tO\n\nThe\tO\nnormalized\tT-0\nreflex\tO\namplitude\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nduring\tT-1\npain\tB-Disease\n,\tO\nbut\tO\nonly\tO\nat\tO\nfaster\tO\nstretches\tO\nin\tO\nthe\tO\npainful\tO\nmuscle\tO\n.\tO\n\nThe\tO\nnormalized\tO\nreflex\tO\namplitude\tO\nwas\tO\nsignificantly\tO\nhigher\tO\nduring\tO\npain\tO\n,\tO\nbut\tO\nonly\tO\nat\tO\nfaster\tO\nstretches\tO\nin\tT-0\nthe\tT-0\npainful\tB-Disease\nmuscle\tI-Disease\n.\tO\n\nIncreased\tO\nsensitivity\tO\nof\tO\nthe\tO\nfusimotor\tO\nsystem\tO\nduring\tO\nacute\tT-0\nmuscle\tB-Disease\npain\tI-Disease\ncould\tO\nbe\tO\none\tO\nlikely\tO\nmechanism\tO\nto\tO\nexplain\tO\nthe\tO\nfindings\tO\n.\tO\n\nEffects\tT-1\nof\tT-1\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tT-0\ninto\tO\nthe\tO\naccumbal\tO\nshell\tO\nor\tO\ncore\tO\non\tO\nthe\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tT-2\nlocomotor\tO\nhyperactivity\tO\nin\tO\nrats\tO\n.\tO\n\nEffects\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\naccumbal\tO\nshell\tO\nor\tO\ncore\tO\non\tO\nthe\tO\ncocaine\tO\n-\tO\ninduced\tT-0\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nexamine\tO\nthe\tO\neffect\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\nsubregions\tO\nof\tO\nthe\tO\nnucleus\tO\naccumbens\tO\n(\tO\nthe\tO\nshell\tO\nand\tO\nthe\tO\ncore\tO\n)\tO\non\tT-0\nthe\tT-0\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\ninduced\tT-1\nby\tT-1\ncocaine\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nexamine\tO\nthe\tO\neffect\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\nsubregions\tO\nof\tO\nthe\tO\nnucleus\tO\naccumbens\tO\n(\tO\nthe\tO\nshell\tO\nand\tO\nthe\tO\ncore\tO\n)\tO\non\tO\nthe\tO\nlocomotor\tO\nhyperactivity\tO\ninduced\tT-0\nby\tT-0\ncocaine\tB-Chemical\nin\tT-1\nrats\tT-1\n.\tO\n\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\nimplanted\tO\nbilaterally\tO\nwith\tO\ncannulae\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\nor\tO\ncore\tO\n,\tO\nand\tO\nthen\tO\nwere\tO\nlocally\tO\ninjected\tT-1\nwith\tT-1\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\nan\tO\nantagonist\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptors\tO\n)\tO\nor\tO\nCP\tO\n93129\tO\n(\tO\nan\tO\nagonist\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptors\tO\n)\tO\n.\tO\n\nMale\tO\nWistar\tO\nrats\tO\nwere\tO\nimplanted\tO\nbilaterally\tO\nwith\tO\ncannulae\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\nor\tO\ncore\tO\n,\tO\nand\tO\nthen\tO\nwere\tO\nlocally\tT-0\ninjected\tT-0\nwith\tT-0\nGR\tO\n55562\tO\n(\tO\nan\tO\nantagonist\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptors\tO\n)\tO\nor\tO\nCP\tB-Chemical\n93129\tI-Chemical\n(\tO\nan\tO\nagonist\tO\nof\tO\n5\tO\n-\tO\nHT1B\tO\nreceptors\tO\n)\tO\n.\tO\n\nGiven\tT-1\nalone\tT-1\nto\tO\nany\tO\naccumbal\tO\nsubregion\tT-0\n,\tO\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\nor\tO\nCP\tO\n93129\tO\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\ndid\tO\nnot\tO\nchange\tO\nbasal\tO\nlocomotor\tO\nactivity\tO\n.\tO\n\nGiven\tO\nalone\tO\nto\tO\nany\tO\naccumbal\tO\nsubregion\tO\n,\tO\nGR\tO\n55562\tO\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\nor\tO\nCP\tB-Chemical\n93129\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\ndid\tT-0\nnot\tT-0\nchange\tT-0\nbasal\tO\nlocomotor\tO\nactivity\tO\n.\tO\n\nSystemic\tT-0\ncocaine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nsignificantly\tT-1\nincreased\tT-1\nthe\tO\nlocomotor\tO\nactivity\tO\nof\tO\nrats\tO\n.\tO\n\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\n,\tO\nadministered\tT-0\nintra\tO\n-\tO\naccumbens\tO\nshell\tO\nprior\tO\nto\tO\ncocaine\tO\n,\tO\ndose\tO\n-\tO\ndependently\tO\nattenuated\tO\nthe\tO\npsychostimulant\tO\n-\tO\ninduced\tT-1\nlocomotor\tO\nhyperactivity\tO\n.\tO\n\nGR\tO\n55562\tO\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\n,\tO\nadministered\tO\nintra\tO\n-\tO\naccumbens\tO\nshell\tO\nprior\tT-0\nto\tT-0\ncocaine\tB-Chemical\n,\tO\ndose\tO\n-\tO\ndependently\tO\nattenuated\tO\nthe\tO\npsychostimulant\tO\n-\tO\ninduced\tT-1\nlocomotor\tT-1\nhyperactivity\tT-1\n.\tT-1\n\nGR\tO\n55562\tO\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\n,\tO\nadministered\tO\nintra\tO\n-\tO\naccumbens\tO\nshell\tO\nprior\tO\nto\tO\ncocaine\tO\n,\tO\ndose\tO\n-\tO\ndependently\tO\nattenuated\tT-0\nthe\tT-0\npsychostimulant\tO\n-\tO\ninduced\tT-1\nlocomotor\tB-Disease\nhyperactivity\tI-Disease\n.\tO\n\nSuch\tO\nattenuation\tO\nwas\tO\nnot\tO\nfound\tO\nin\tO\nanimals\tO\nwhich\tO\nhad\tO\nbeen\tO\ninjected\tT-0\nwith\tT-0\nGR\tB-Chemical\n55562\tI-Chemical\ninto\tT-1\nthe\tT-1\naccumbens\tT-1\ncore\tT-1\n.\tO\n\nWhen\tT-0\ninjected\tT-0\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n(\tO\nbut\tO\nnot\tO\nthe\tO\ncore\tO\n)\tO\nbefore\tT-3\ncocaine\tB-Chemical\n,\tT-4\nCP\tT-4\n93129\tT-4\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\nenhanced\tT-1\nthe\tT-1\nlocomotor\tT-1\nresponse\tT-1\nto\tO\ncocaine\tO\n;\tO\nthe\tO\nmaximum\tT-2\neffect\tT-2\nbeing\tO\nobserved\tO\nafter\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\nof\tO\nthe\tO\nagonist\tO\n.\tO\n\nWhen\tO\ninjected\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n(\tO\nbut\tO\nnot\tO\nthe\tO\ncore\tO\n)\tO\nbefore\tT-0\ncocaine\tT-0\n,\tO\nCP\tB-Chemical\n93129\tI-Chemical\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\nenhanced\tO\nthe\tO\nlocomotor\tO\nresponse\tO\nto\tO\ncocaine\tO\n;\tO\nthe\tO\nmaximum\tO\neffect\tO\nbeing\tO\nobserved\tO\nafter\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\nof\tO\nthe\tO\nagonist\tO\n.\tO\n\nWhen\tO\ninjected\tT-0\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n(\tO\nbut\tO\nnot\tO\nthe\tO\ncore\tO\n)\tO\nbefore\tO\ncocaine\tO\n,\tO\nCP\tO\n93129\tO\n(\tO\n0\tO\n.\tO\n1\tO\n-\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\nenhanced\tO\nthe\tO\nlocomotor\tO\nresponse\tT-1\nto\tT-1\ncocaine\tB-Chemical\n;\tO\nthe\tT-2\nmaximum\tT-2\neffect\tO\nbeing\tO\nobserved\tO\nafter\tO\n10\tO\nmicrog\tO\n/\tO\nside\tO\nof\tO\nthe\tO\nagonist\tO\n.\tO\n\nThe\tO\nlater\tO\nenhancement\tO\nwas\tO\nattenuated\tO\nafter\tO\nintra\tO\n-\tO\naccumbens\tO\nshell\tO\ntreatment\tT-1\nwith\tT-1\nGR\tB-Chemical\n55562\tI-Chemical\n(\tO\n1\tO\nmicrog\tO\n/\tO\nside\tO\n)\tO\n.\tO\n\nOur\tO\nfindings\tO\nindicate\tO\nthat\tO\ncocaine\tB-Chemical\ninduced\tT-2\nhyperlocomotion\tO\nis\tO\nmodified\tO\nby\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tT-0\ninto\tT-0\nthe\tO\naccumbens\tO\nshell\tO\n,\tO\nbut\tO\nnot\tO\ncore\tO\n,\tO\nthis\tO\nmodification\tO\nconsisting\tO\nin\tO\ninhibitory\tT-1\nand\tT-1\nfacilitatory\tT-1\neffects\tT-1\nof\tO\nthe\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nantagonist\tO\n(\tO\nGR\tO\n55562\tO\n)\tO\nand\tO\nagonist\tO\n(\tO\nCP\tO\n93129\tO\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nOur\tO\nfindings\tO\nindicate\tO\nthat\tO\ncocaine\tO\ninduced\tT-2\nhyperlocomotion\tB-Disease\nis\tT-1\nmodified\tT-1\nby\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n,\tO\nbut\tO\nnot\tO\ncore\tO\n,\tO\nthis\tO\nmodification\tO\nconsisting\tO\nin\tO\ninhibitory\tO\nand\tO\nfacilitatory\tO\neffects\tO\nof\tO\nthe\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nantagonist\tO\n(\tO\nGR\tO\n55562\tO\n)\tO\nand\tO\nagonist\tO\n(\tO\nCP\tO\n93129\tO\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nOur\tO\nfindings\tO\nindicate\tO\nthat\tO\ncocaine\tO\ninduced\tO\nhyperlocomotion\tO\nis\tO\nmodified\tO\nby\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n,\tO\nbut\tO\nnot\tO\ncore\tO\n,\tO\nthis\tO\nmodification\tO\nconsisting\tO\nin\tO\ninhibitory\tO\nand\tO\nfacilitatory\tT-0\neffects\tT-0\nof\tT-0\nthe\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nantagonist\tO\n(\tO\nGR\tB-Chemical\n55562\tI-Chemical\n)\tO\nand\tO\nagonist\tO\n(\tO\nCP\tO\n93129\tO\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nOur\tO\nfindings\tO\nindicate\tO\nthat\tO\ncocaine\tO\ninduced\tO\nhyperlocomotion\tO\nis\tO\nmodified\tO\nby\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nligands\tO\nmicroinjected\tO\ninto\tO\nthe\tO\naccumbens\tO\nshell\tO\n,\tO\nbut\tO\nnot\tO\ncore\tO\n,\tO\nthis\tO\nmodification\tO\nconsisting\tO\nin\tO\ninhibitory\tO\nand\tO\nfacilitatory\tO\neffects\tO\nof\tO\nthe\tO\n5\tO\n-\tO\nHT1B\tO\nreceptor\tO\nantagonist\tO\n(\tO\nGR\tO\n55562\tO\n)\tO\nand\tO\nagonist\tT-0\n(\tO\nCP\tB-Chemical\n93129\tI-Chemical\n)\tO\n,\tO\nrespectively\tO\n.\tO\n\nCocaine\tB-Chemical\nrelated\tT-0\nchest\tT-0\npain\tT-0\n:\tO\nare\tO\nwe\tO\nseeing\tO\nthe\tO\ntip\tO\nof\tO\nan\tO\niceberg\tO\n?\tO\n\nCocaine\tO\nrelated\tT-0\nchest\tB-Disease\npain\tI-Disease\n:\tO\nare\tO\nwe\tO\nseeing\tO\nthe\tO\ntip\tO\nof\tO\nan\tO\niceberg\tO\n?\tO\n\nThe\tO\nrecreational\tO\nuse\tT-1\nof\tT-1\ncocaine\tB-Chemical\nis\tT-0\non\tT-0\nthe\tT-0\nincrease\tT-0\n.\tO\n\nThe\tO\nemergency\tO\nnurse\tO\nought\tO\nto\tO\nbe\tO\nfamiliar\tO\nwith\tO\nsome\tO\nof\tO\nthe\tO\ncardiovascular\tO\nconsequences\tT-2\nof\tT-2\ncocaine\tB-Chemical\nuse\tT-1\n.\tO\n\nIn\tO\nparticular\tO\n,\tO\nthe\tO\ntendency\tT-1\nof\tT-1\ncocaine\tB-Chemical\nto\tT-0\nproduce\tT-0\nchest\tO\npain\tO\nought\tO\nto\tO\nbe\tO\nin\tO\nthe\tO\nmind\tO\nof\tO\nthe\tO\nemergency\tO\nnurse\tO\nwhen\tO\nfaced\tO\nwith\tO\na\tO\nyoung\tO\nvictim\tO\nof\tO\nchest\tO\npain\tO\nwho\tO\nis\tO\notherwise\tO\nat\tO\nlow\tO\nrisk\tO\n.\tO\n\nIn\tO\nparticular\tO\n,\tO\nthe\tO\ntendency\tO\nof\tO\ncocaine\tO\nto\tT-0\nproduce\tT-0\nchest\tB-Disease\npain\tI-Disease\nought\tT-1\nto\tT-1\nbe\tT-1\nin\tO\nthe\tO\nmind\tO\nof\tO\nthe\tO\nemergency\tO\nnurse\tO\nwhen\tO\nfaced\tO\nwith\tO\na\tO\nyoung\tO\nvictim\tO\nof\tO\nchest\tO\npain\tO\nwho\tO\nis\tO\notherwise\tO\nat\tO\nlow\tO\nrisk\tO\n.\tO\n\nIn\tO\nparticular\tO\n,\tO\nthe\tO\ntendency\tO\nof\tO\ncocaine\tO\nto\tO\nproduce\tO\nchest\tO\npain\tO\nought\tO\nto\tO\nbe\tO\nin\tO\nthe\tO\nmind\tO\nof\tO\nthe\tO\nemergency\tO\nnurse\tO\nwhen\tO\nfaced\tO\nwith\tO\na\tO\nyoung\tO\nvictim\tT-1\nof\tT-1\nchest\tB-Disease\npain\tI-Disease\nwho\tT-0\nis\tT-0\notherwise\tT-0\nat\tT-0\nlow\tT-0\nrisk\tT-0\n.\tO\n\nThe\tT-1\nmechanism\tT-1\nof\tO\nchest\tB-Disease\npain\tI-Disease\nrelated\tO\nto\tO\ncocaine\tO\nuse\tO\nis\tO\ndiscussed\tO\nand\tO\ntreatment\tO\ndilemmas\tO\nare\tO\ndiscussed\tO\n.\tO\n\nThe\tO\nmechanism\tO\nof\tO\nchest\tO\npain\tO\nrelated\tT-1\nto\tT-1\ncocaine\tB-Chemical\nuse\tT-0\nis\tO\ndiscussed\tO\nand\tO\ntreatment\tT-2\ndilemmas\tT-2\nare\tO\ndiscussed\tO\n.\tO\n\nFinally\tO\n,\tO\nmoral\tO\nissues\tO\nrelating\tO\nto\tT-1\nthe\tT-1\ntesting\tT-1\nof\tT-1\npotential\tT-1\ncocaine\tB-Chemical\nusers\tT-2\nwill\tT-2\nbe\tT-2\naddressed\tT-2\n.\tO\n\nCrossover\tO\ncomparison\tT-1\nof\tO\nefficacy\tT-0\nand\tT-0\npreference\tO\nfor\tO\nrizatriptan\tB-Chemical\n10\tO\nmg\tO\nversus\tO\nergotamine\tO\n/\tO\ncaffeine\tO\nin\tO\nmigraine\tO\n.\tO\n\nCrossover\tO\ncomparison\tT-2\nof\tT-2\nefficacy\tT-2\nand\tO\npreference\tO\nfor\tO\nrizatriptan\tO\n10\tO\nmg\tO\nversus\tT-0\nergotamine\tB-Chemical\n/\tO\ncaffeine\tT-3\nin\tT-3\nmigraine\tT-3\n.\tO\n\nCrossover\tO\ncomparison\tT-1\nof\tT-1\nefficacy\tT-1\nand\tO\npreference\tO\nfor\tO\nrizatriptan\tO\n10\tO\nmg\tO\nversus\tO\nergotamine\tO\n/\tO\ncaffeine\tB-Chemical\nin\tT-0\nmigraine\tT-0\n.\tO\n\nCrossover\tT-1\ncomparison\tT-1\nof\tO\nefficacy\tO\nand\tO\npreference\tO\nfor\tO\nrizatriptan\tO\n10\tO\nmg\tO\nversus\tT-2\nergotamine\tO\n/\tO\ncaffeine\tO\nin\tT-0\nmigraine\tB-Disease\n.\tO\n\nRizatriptan\tB-Chemical\nis\tT-0\na\tT-0\nselective\tO\n5\tO\n-\tO\nHT\tO\n(\tO\n1B\tO\n/\tO\n1D\tO\n)\tO\nreceptor\tO\nagonist\tT-1\nwith\tT-1\nrapid\tO\noral\tO\nabsorption\tO\nand\tO\nearly\tO\nonset\tO\nof\tO\naction\tO\nin\tO\nthe\tO\nacute\tO\ntreatment\tO\nof\tO\nmigraine\tO\n.\tO\n\nRizatriptan\tO\nis\tT-0\na\tT-0\nselective\tT-0\n5\tB-Chemical\n-\tI-Chemical\nHT\tI-Chemical\n(\tO\n1B\tO\n/\tO\n1D\tO\n)\tO\nreceptor\tT-1\nagonist\tO\nwith\tO\nrapid\tO\noral\tO\nabsorption\tO\nand\tO\nearly\tO\nonset\tO\nof\tO\naction\tO\nin\tO\nthe\tO\nacute\tO\ntreatment\tT-2\nof\tO\nmigraine\tO\n.\tO\n\nRizatriptan\tO\nis\tO\na\tO\nselective\tO\n5\tO\n-\tO\nHT\tO\n(\tO\n1B\tO\n/\tO\n1D\tO\n)\tO\nreceptor\tO\nagonist\tO\nwith\tO\nrapid\tT-0\noral\tT-0\nabsorption\tT-2\nand\tO\nearly\tO\nonset\tT-1\nof\tO\naction\tO\nin\tO\nthe\tO\nacute\tO\ntreatment\tO\nof\tO\nmigraine\tB-Disease\n.\tO\n\nThis\tO\nrandomized\tO\ndouble\tO\n-\tO\nblind\tO\ncrossover\tO\noutpatient\tO\nstudy\tO\nassessed\tO\nthe\tO\npreference\tT-1\nfor\tT-1\n1\tT-1\nrizatriptan\tB-Chemical\n10\tT-2\nmg\tT-2\ntablet\tT-2\nto\tO\n2\tO\nergotamine\tO\n1\tO\nmg\tO\n/\tO\ncaffeine\tO\n100\tO\nmg\tO\ntablets\tO\nin\tO\n439\tO\npatients\tO\ntreating\tO\na\tO\nsingle\tO\nmigraine\tO\nattack\tO\nwith\tO\neach\tO\ntherapy\tO\n.\tO\n\nThis\tO\nrandomized\tO\ndouble\tO\n-\tO\nblind\tO\ncrossover\tO\noutpatient\tO\nstudy\tO\nassessed\tT-0\nthe\tT-0\npreference\tT-0\nfor\tO\n1\tO\nrizatriptan\tO\n10\tO\nmg\tO\ntablet\tO\nto\tO\n2\tO\nergotamine\tB-Chemical\n1\tO\nmg\tO\n/\tO\ncaffeine\tO\n100\tO\nmg\tO\ntablets\tO\nin\tO\n439\tO\npatients\tO\ntreating\tO\na\tO\nsingle\tO\nmigraine\tO\nattack\tO\nwith\tO\neach\tO\ntherapy\tO\n.\tO\n\nThis\tO\nrandomized\tO\ndouble\tO\n-\tO\nblind\tO\ncrossover\tO\noutpatient\tO\nstudy\tO\nassessed\tO\nthe\tO\npreference\tO\nfor\tO\n1\tO\nrizatriptan\tO\n10\tO\nmg\tO\ntablet\tO\nto\tO\n2\tO\nergotamine\tT-0\n1\tT-0\nmg\tT-0\n/\tT-0\ncaffeine\tB-Chemical\n100\tT-1\nmg\tT-1\ntablets\tT-1\nin\tO\n439\tO\npatients\tO\ntreating\tO\na\tO\nsingle\tO\nmigraine\tO\nattack\tO\nwith\tO\neach\tO\ntherapy\tO\n.\tO\n\nThis\tO\nrandomized\tO\ndouble\tO\n-\tO\nblind\tO\ncrossover\tO\noutpatient\tO\nstudy\tO\nassessed\tO\nthe\tO\npreference\tO\nfor\tO\n1\tO\nrizatriptan\tO\n10\tO\nmg\tO\ntablet\tO\nto\tO\n2\tO\nergotamine\tO\n1\tO\nmg\tO\n/\tO\ncaffeine\tO\n100\tO\nmg\tO\ntablets\tO\nin\tO\n439\tO\npatients\tO\ntreating\tT-0\na\tT-0\nsingle\tT-0\nmigraine\tB-Disease\nattack\tT-1\nwith\tT-1\neach\tT-1\ntherapy\tT-1\n.\tO\n\nOf\tO\npatients\tO\nexpressing\tO\na\tO\npreference\tO\n(\tO\n89\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nmore\tO\nthan\tO\ntwice\tT-1\nas\tT-1\nmany\tT-1\npreferred\tT-1\nrizatriptan\tB-Chemical\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\n69\tO\n.\tO\n9\tO\nvs\tO\n.\tO\n30\tO\n.\tO\n1\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nOf\tO\npatients\tO\nexpressing\tO\na\tO\npreference\tO\n(\tO\n89\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nmore\tO\nthan\tO\ntwice\tO\nas\tO\nmany\tT-0\npreferred\tT-0\nrizatriptan\tO\nto\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tO\n(\tO\n69\tO\n.\tO\n9\tO\nvs\tO\n.\tO\n30\tO\n.\tO\n1\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nOf\tO\npatients\tO\nexpressing\tO\na\tO\npreference\tO\n(\tO\n89\tO\n.\tO\n1\tO\n%\tO\n)\tO\n,\tO\nmore\tO\nthan\tO\ntwice\tT-0\nas\tT-0\nmany\tT-0\npreferred\tT-0\nrizatriptan\tO\nto\tT-1\nergotamine\tT-1\n/\tO\ncaffeine\tB-Chemical\n(\tO\n69\tO\n.\tO\n9\tO\nvs\tO\n.\tO\n30\tO\n.\tO\n1\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nFaster\tO\nrelief\tT-1\nof\tT-1\nheadache\tB-Disease\nwas\tO\nthe\tO\nmost\tO\nimportant\tO\nreason\tO\nfor\tO\npreference\tO\n,\tO\ncited\tO\nby\tO\n67\tO\n.\tO\n3\tO\n%\tO\nof\tO\npatients\tO\npreferring\tO\nrizatriptan\tO\nand\tO\n54\tO\n.\tO\n2\tO\n%\tO\nof\tO\npatients\tO\nwho\tO\npreferred\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n.\tO\n\nFaster\tO\nrelief\tO\nof\tO\nheadache\tO\nwas\tO\nthe\tO\nmost\tO\nimportant\tO\nreason\tO\nfor\tO\npreference\tO\n,\tO\ncited\tO\nby\tO\n67\tO\n.\tO\n3\tO\n%\tO\nof\tO\npatients\tO\npreferring\tO\nrizatriptan\tO\nand\tO\n54\tO\n.\tO\n2\tO\n%\tO\nof\tO\npatients\tO\nwho\tO\npreferred\tT-0\nergotamine\tB-Chemical\n/\tO\ncaffeine\tO\n.\tO\n\nFaster\tT-0\nrelief\tT-0\nof\tT-0\nheadache\tT-0\nwas\tO\nthe\tO\nmost\tO\nimportant\tO\nreason\tO\nfor\tO\npreference\tO\n,\tO\ncited\tO\nby\tO\n67\tO\n.\tO\n3\tO\n%\tO\nof\tO\npatients\tO\npreferring\tT-1\nrizatriptan\tT-1\nand\tO\n54\tO\n.\tO\n2\tO\n%\tO\nof\tO\npatients\tT-2\nwho\tT-2\npreferred\tT-2\nergotamine\tO\n/\tO\ncaffeine\tB-Chemical\n.\tO\n\nThe\tO\nco\tO\n-\tO\nprimary\tO\nendpoint\tO\nof\tT-0\nbeing\tT-0\npain\tB-Disease\nfree\tT-1\nat\tO\n2\tO\nh\tO\nwas\tO\nalso\tO\nin\tO\nfavor\tO\nof\tO\nrizatriptan\tO\n.\tO\n\nForty\tO\n-\tO\nnine\tT-0\npercent\tT-0\nof\tT-0\npatients\tT-0\nwere\tO\npain\tB-Disease\nfree\tO\n2\tO\nh\tO\nafter\tO\nrizatriptan\tO\n,\tO\ncompared\tO\nwith\tO\n24\tO\n.\tO\n3\tO\n%\tO\ntreated\tO\nwith\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tO\nwithin\tO\n1\tO\nh\tO\nof\tO\ntreatment\tO\n.\tO\n\nForty\tO\n-\tO\nnine\tO\npercent\tO\nof\tO\npatients\tO\nwere\tO\npain\tO\nfree\tO\n2\tO\nh\tO\nafter\tT-0\nrizatriptan\tB-Chemical\n,\tO\ncompared\tT-1\nwith\tT-1\n24\tO\n.\tO\n3\tO\n%\tO\ntreated\tO\nwith\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tO\nwithin\tO\n1\tO\nh\tO\nof\tO\ntreatment\tO\n.\tO\n\nForty\tO\n-\tO\nnine\tO\npercent\tO\nof\tO\npatients\tO\nwere\tO\npain\tO\nfree\tO\n2\tO\nh\tO\nafter\tO\nrizatriptan\tO\n,\tO\ncompared\tO\nwith\tO\n24\tO\n.\tO\n3\tO\n%\tO\ntreated\tT-0\nwith\tT-0\nergotamine\tB-Chemical\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tO\nwithin\tO\n1\tO\nh\tO\nof\tO\ntreatment\tO\n.\tO\n\nForty\tO\n-\tO\nnine\tO\npercent\tO\nof\tO\npatients\tO\nwere\tO\npain\tO\nfree\tO\n2\tO\nh\tO\nafter\tO\nrizatriptan\tO\n,\tO\ncompared\tO\nwith\tO\n24\tO\n.\tO\n3\tO\n%\tO\ntreated\tT-0\nwith\tT-0\nergotamine\tO\n/\tO\ncaffeine\tB-Chemical\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tO\nwithin\tO\n1\tO\nh\tO\nof\tO\ntreatment\tO\n.\tO\n\nForty\tO\n-\tO\nnine\tO\npercent\tO\nof\tO\npatients\tO\nwere\tO\npain\tO\nfree\tO\n2\tO\nh\tO\nafter\tO\nrizatriptan\tO\n,\tO\ncompared\tO\nwith\tO\n24\tO\n.\tO\n3\tO\n%\tO\ntreated\tT-0\nwith\tT-0\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nrizatriptan\tB-Chemical\nbeing\tT-1\nsuperior\tT-1\nwithin\tO\n1\tO\nh\tO\nof\tO\ntreatment\tO\n.\tO\n\nHeadache\tB-Disease\nrelief\tO\nat\tO\n2\tO\nh\tO\nwas\tO\n75\tO\n.\tO\n9\tO\n%\tO\nfor\tO\nrizatriptan\tO\nand\tO\n47\tO\n.\tO\n3\tO\n%\tO\nfor\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nwith\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tO\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tO\nwithin\tO\n30\tO\nmin\tO\nof\tO\ndosing\tT-0\n.\tO\n\nHeadache\tO\nrelief\tO\nat\tO\n2\tO\nh\tO\nwas\tO\n75\tT-0\n.\tT-0\n9\tT-0\n%\tT-0\nfor\tT-0\nrizatriptan\tB-Chemical\nand\tT-1\n47\tT-1\n.\tT-1\n3\tT-1\n%\tT-1\nfor\tT-1\nergotamine\tT-1\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nwith\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tO\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tO\nwithin\tO\n30\tO\nmin\tO\nof\tO\ndosing\tO\n.\tO\n\nHeadache\tT-1\nrelief\tT-1\nat\tO\n2\tO\nh\tO\nwas\tO\n75\tO\n.\tO\n9\tO\n%\tO\nfor\tO\nrizatriptan\tO\nand\tO\n47\tO\n.\tO\n3\tO\n%\tO\nfor\tT-0\nergotamine\tB-Chemical\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nwith\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tO\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tO\nwithin\tT-2\n30\tT-2\nmin\tT-2\nof\tT-2\ndosing\tT-2\n.\tO\n\nHeadache\tT-0\nrelief\tT-0\nat\tO\n2\tO\nh\tO\nwas\tO\n75\tO\n.\tO\n9\tO\n%\tO\nfor\tO\nrizatriptan\tO\nand\tO\n47\tO\n.\tO\n3\tO\n%\tO\nfor\tO\nergotamine\tT-1\n/\tO\ncaffeine\tB-Chemical\n(\tT-2\np\tT-2\n<\tT-2\nor\tT-2\n=\tT-2\n0\tT-2\n.\tT-2\n001\tT-2\n)\tT-2\n,\tO\nwith\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tO\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tO\nwithin\tO\n30\tO\nmin\tO\nof\tO\ndosing\tO\n.\tO\n\nHeadache\tO\nrelief\tO\nat\tO\n2\tO\nh\tO\nwas\tO\n75\tO\n.\tO\n9\tO\n%\tO\nfor\tO\nrizatriptan\tO\nand\tO\n47\tO\n.\tO\n3\tO\n%\tO\nfor\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nwith\tO\nrizatriptan\tB-Chemical\nbeing\tT-0\nsuperior\tT-0\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tO\nwithin\tO\n30\tO\nmin\tO\nof\tO\ndosing\tO\n.\tO\n\nHeadache\tO\nrelief\tO\nat\tO\n2\tO\nh\tO\nwas\tO\n75\tO\n.\tO\n9\tO\n%\tO\nfor\tO\nrizatriptan\tO\nand\tO\n47\tO\n.\tO\n3\tO\n%\tO\nfor\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nwith\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tT-0\nto\tT-0\nergotamine\tB-Chemical\n/\tO\ncaffeine\tO\nwithin\tO\n30\tO\nmin\tO\nof\tO\ndosing\tT-1\n.\tO\n\nHeadache\tT-0\nrelief\tT-0\nat\tO\n2\tO\nh\tO\nwas\tO\n75\tO\n.\tO\n9\tO\n%\tO\nfor\tO\nrizatriptan\tO\nand\tO\n47\tO\n.\tO\n3\tO\n%\tO\nfor\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n,\tO\nwith\tO\nrizatriptan\tO\nbeing\tO\nsuperior\tO\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tB-Chemical\nwithin\tO\n30\tO\nmin\tO\nof\tO\ndosing\tT-1\n.\tO\n\nAlmost\tO\n36\tO\n%\tO\nof\tO\npatients\tT-0\ntaking\tT-2\nrizatriptan\tB-Chemical\nwere\tT-3\npain\tT-3\nfree\tO\nat\tO\n2\tO\nh\tO\nand\tO\nhad\tO\nno\tO\nrecurrence\tO\nor\tO\nneed\tO\nfor\tO\nadditional\tO\nmedication\tO\nwithin\tO\n24\tO\nh\tO\n,\tO\ncompared\tO\nto\tO\n20\tO\n%\tO\nof\tO\npatients\tT-1\non\tT-1\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nAlmost\tO\n36\tO\n%\tO\nof\tO\npatients\tO\ntaking\tT-0\nrizatriptan\tO\nwere\tO\npain\tB-Disease\nfree\tT-1\nat\tO\n2\tO\nh\tO\nand\tO\nhad\tO\nno\tO\nrecurrence\tT-2\nor\tO\nneed\tO\nfor\tO\nadditional\tO\nmedication\tO\nwithin\tO\n24\tO\nh\tO\n,\tO\ncompared\tO\nto\tO\n20\tO\n%\tO\nof\tO\npatients\tO\non\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nAlmost\tO\n36\tO\n%\tO\nof\tO\npatients\tO\ntaking\tO\nrizatriptan\tO\nwere\tO\npain\tO\nfree\tO\nat\tO\n2\tO\nh\tO\nand\tO\nhad\tO\nno\tO\nrecurrence\tO\nor\tO\nneed\tO\nfor\tO\nadditional\tO\nmedication\tO\nwithin\tO\n24\tO\nh\tO\n,\tO\ncompared\tO\nto\tO\n20\tO\n%\tO\nof\tO\npatients\tT-0\non\tT-0\nergotamine\tB-Chemical\n/\tO\ncaffeine\tT-1\n(\tT-1\np\tT-1\n<\tT-1\nor\tT-1\n=\tT-1\n0\tT-1\n.\tT-1\n001\tT-1\n)\tO\n.\tO\n\nAlmost\tO\n36\tO\n%\tO\nof\tO\npatients\tO\ntaking\tO\nrizatriptan\tO\nwere\tO\npain\tO\nfree\tO\nat\tO\n2\tO\nh\tO\nand\tO\nhad\tO\nno\tO\nrecurrence\tO\nor\tO\nneed\tO\nfor\tO\nadditional\tO\nmedication\tO\nwithin\tO\n24\tO\nh\tO\n,\tO\ncompared\tO\nto\tO\n20\tO\n%\tO\nof\tO\npatients\tT-0\non\tT-0\nergotamine\tO\n/\tO\ncaffeine\tB-Chemical\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRizatriptan\tB-Chemical\nwas\tT-1\nalso\tT-1\nsuperior\tT-1\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tO\nin\tO\nthe\tO\nproportions\tO\nof\tO\npatients\tO\nwith\tO\nno\tO\nnausea\tO\n,\tO\nvomiting\tO\n,\tO\nphonophobia\tO\nor\tO\nphotophobia\tO\nand\tO\nfor\tO\npatients\tO\nwith\tO\nnormal\tO\nfunction\tO\n2\tO\nh\tO\nafter\tT-0\ndrug\tT-0\nintake\tT-0\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRizatriptan\tO\nwas\tO\nalso\tO\nsuperior\tT-1\nto\tT-1\nergotamine\tB-Chemical\n/\tO\ncaffeine\tO\nin\tO\nthe\tO\nproportions\tO\nof\tO\npatients\tO\nwith\tO\nno\tO\nnausea\tO\n,\tO\nvomiting\tO\n,\tO\nphonophobia\tO\nor\tO\nphotophobia\tO\nand\tO\nfor\tO\npatients\tT-0\nwith\tO\nnormal\tO\nfunction\tO\n2\tO\nh\tO\nafter\tO\ndrug\tO\nintake\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRizatriptan\tO\nwas\tO\nalso\tO\nsuperior\tT-0\nto\tT-0\nergotamine\tO\n/\tO\ncaffeine\tB-Chemical\nin\tO\nthe\tO\nproportions\tO\nof\tO\npatients\tO\nwith\tO\nno\tO\nnausea\tO\n,\tO\nvomiting\tO\n,\tO\nphonophobia\tO\nor\tO\nphotophobia\tO\nand\tO\nfor\tO\npatients\tO\nwith\tO\nnormal\tO\nfunction\tO\n2\tO\nh\tO\nafter\tO\ndrug\tO\nintake\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRizatriptan\tO\nwas\tO\nalso\tO\nsuperior\tO\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tO\nin\tO\nthe\tO\nproportions\tO\nof\tO\npatients\tO\nwith\tT-0\nno\tT-0\nnausea\tB-Disease\n,\tO\nvomiting\tO\n,\tO\nphonophobia\tO\nor\tO\nphotophobia\tO\nand\tO\nfor\tO\npatients\tO\nwith\tO\nnormal\tO\nfunction\tO\n2\tO\nh\tO\nafter\tO\ndrug\tO\nintake\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRizatriptan\tO\nwas\tO\nalso\tO\nsuperior\tO\nto\tO\nergotamine\tO\n/\tO\ncaffeine\tO\nin\tO\nthe\tO\nproportions\tO\nof\tO\npatients\tO\nwith\tO\nno\tT-1\nnausea\tT-1\n,\tT-1\nvomiting\tT-1\n,\tO\nphonophobia\tB-Disease\nor\tO\nphotophobia\tT-2\nand\tO\nfor\tO\npatients\tO\nwith\tO\nnormal\tO\nfunction\tO\n2\tO\nh\tO\nafter\tO\ndrug\tO\nintake\tO\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRizatriptan\tO\nwas\tO\nalso\tO\nsuperior\tT-3\nto\tT-3\nergotamine\tO\n/\tO\ncaffeine\tO\nin\tO\nthe\tO\nproportions\tO\nof\tO\npatients\tT-2\nwith\tT-2\nno\tO\nnausea\tO\n,\tO\nvomiting\tO\n,\tO\nphonophobia\tT-0\nor\tT-0\nphotophobia\tB-Disease\nand\tT-1\nfor\tT-1\npatients\tT-1\nwith\tO\nnormal\tO\nfunction\tO\n2\tO\nh\tO\nafter\tO\ndrug\tO\nintake\tT-4\n(\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nMore\tO\npatients\tO\nwere\tO\n(\tO\ncompletely\tO\n,\tO\nvery\tO\nor\tO\nsomewhat\tO\n)\tO\nsatisfied\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tT-0\nwith\tT-0\nrizatriptan\tB-Chemical\n(\tO\n69\tO\n.\tO\n8\tO\n%\tO\n)\tO\nthan\tO\nat\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tO\nwith\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n(\tO\n38\tO\n.\tO\n6\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nMore\tO\npatients\tO\nwere\tO\n(\tO\ncompletely\tO\n,\tO\nvery\tO\nor\tO\nsomewhat\tO\n)\tO\nsatisfied\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tO\nwith\tO\nrizatriptan\tO\n(\tO\n69\tO\n.\tO\n8\tO\n%\tO\n)\tO\nthan\tO\nat\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tT-1\nwith\tT-1\nergotamine\tB-Chemical\n/\tT-0\ncaffeine\tT-0\n(\tO\n38\tO\n.\tO\n6\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nMore\tO\npatients\tO\nwere\tO\n(\tO\ncompletely\tO\n,\tO\nvery\tO\nor\tO\nsomewhat\tO\n)\tO\nsatisfied\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tO\nwith\tO\nrizatriptan\tO\n(\tO\n69\tO\n.\tO\n8\tO\n%\tO\n)\tO\nthan\tO\nat\tO\n2\tO\nh\tO\nafter\tO\ntreatment\tT-0\nwith\tT-0\nergotamine\tO\n/\tO\ncaffeine\tB-Chemical\n(\tO\n38\tO\n.\tO\n6\tO\n%\tO\n,\tO\np\tO\n<\tO\nor\tO\n=\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nRecurrence\tT-0\nrates\tT-0\nwere\tO\n31\tO\n.\tO\n4\tO\n%\tO\nwith\tO\nrizatriptan\tB-Chemical\nand\tO\n15\tO\n.\tO\n3\tO\n%\tO\nwith\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n.\tO\n\nRecurrence\tT-0\nrates\tT-0\nwere\tT-0\n31\tO\n.\tO\n4\tO\n%\tO\nwith\tO\nrizatriptan\tO\nand\tO\n15\tO\n.\tO\n3\tO\n%\tO\nwith\tT-1\nergotamine\tB-Chemical\n/\tO\ncaffeine\tO\n.\tO\n\nRecurrence\tT-1\nrates\tT-1\nwere\tT-1\n31\tO\n.\tO\n4\tO\n%\tO\nwith\tO\nrizatriptan\tO\nand\tO\n15\tO\n.\tO\n3\tO\n%\tO\nwith\tT-2\nergotamine\tO\n/\tO\ncaffeine\tB-Chemical\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tO\nevents\tO\n(\tO\nincidence\tO\n>\tO\nor\tO\n=\tO\n5\tO\n%\tO\nin\tO\none\tO\ngroup\tO\n)\tO\nafter\tT-0\nrizatriptan\tB-Chemical\nand\tT-1\nergotamine\tT-1\n/\tO\ncaffeine\tO\n,\tO\nrespectively\tO\n,\tO\nwere\tO\ndizziness\tO\n(\tO\n6\tO\n.\tO\n7\tO\nand\tO\n5\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nnausea\tO\n(\tO\n4\tO\n.\tO\n2\tO\nand\tO\n8\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\nsomnolence\tO\n(\tO\n5\tO\n.\tO\n5\tO\nand\tO\n2\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThe\tT-1\nmost\tT-1\ncommon\tT-1\nadverse\tT-1\nevents\tT-1\n(\tO\nincidence\tO\n>\tO\nor\tO\n=\tO\n5\tO\n%\tO\nin\tO\none\tO\ngroup\tO\n)\tO\nafter\tT-0\nrizatriptan\tO\nand\tO\nergotamine\tB-Chemical\n/\tO\ncaffeine\tO\n,\tO\nrespectively\tO\n,\tO\nwere\tO\ndizziness\tO\n(\tO\n6\tO\n.\tO\n7\tO\nand\tO\n5\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nnausea\tO\n(\tO\n4\tO\n.\tO\n2\tO\nand\tO\n8\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\nsomnolence\tO\n(\tO\n5\tO\n.\tO\n5\tO\nand\tO\n2\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tT-0\nevents\tT-0\n(\tO\nincidence\tO\n>\tO\nor\tO\n=\tO\n5\tO\n%\tO\nin\tO\none\tO\ngroup\tO\n)\tO\nafter\tO\nrizatriptan\tO\nand\tO\nergotamine\tT-1\n/\tO\ncaffeine\tB-Chemical\n,\tO\nrespectively\tT-2\n,\tO\nwere\tO\ndizziness\tO\n(\tO\n6\tO\n.\tO\n7\tO\nand\tO\n5\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nnausea\tO\n(\tO\n4\tO\n.\tO\n2\tO\nand\tO\n8\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\nsomnolence\tO\n(\tO\n5\tO\n.\tO\n5\tO\nand\tO\n2\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tT-0\nevents\tT-0\n(\tO\nincidence\tO\n>\tO\nor\tO\n=\tO\n5\tO\n%\tO\nin\tO\none\tO\ngroup\tO\n)\tO\nafter\tO\nrizatriptan\tO\nand\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n,\tO\nrespectively\tO\n,\tO\nwere\tO\ndizziness\tB-Disease\n(\tO\n6\tO\n.\tO\n7\tO\nand\tO\n5\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nnausea\tO\n(\tO\n4\tO\n.\tO\n2\tO\nand\tO\n8\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\nsomnolence\tO\n(\tO\n5\tO\n.\tO\n5\tO\nand\tO\n2\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tT-1\nevents\tT-1\n(\tO\nincidence\tO\n>\tO\nor\tO\n=\tO\n5\tO\n%\tO\nin\tO\none\tO\ngroup\tO\n)\tO\nafter\tO\nrizatriptan\tO\nand\tO\nergotamine\tO\n/\tO\ncaffeine\tO\n,\tO\nrespectively\tO\n,\tO\nwere\tO\ndizziness\tO\n(\tO\n6\tO\n.\tO\n7\tO\nand\tO\n5\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nnausea\tB-Disease\n(\tO\n4\tO\n.\tO\n2\tO\nand\tO\n8\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tT-0\nsomnolence\tT-0\n(\tO\n5\tO\n.\tO\n5\tO\nand\tO\n2\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThe\tO\nmost\tO\ncommon\tO\nadverse\tT-0\nevents\tT-0\n(\tO\nincidence\tO\n>\tO\nor\tO\n=\tO\n5\tO\n%\tO\nin\tO\none\tO\ngroup\tO\n)\tO\nafter\tT-1\nrizatriptan\tT-1\nand\tT-1\nergotamine\tT-1\n/\tO\ncaffeine\tO\n,\tO\nrespectively\tO\n,\tO\nwere\tO\ndizziness\tO\n(\tO\n6\tO\n.\tO\n7\tO\nand\tO\n5\tO\n.\tO\n3\tO\n%\tO\n)\tO\n,\tO\nnausea\tO\n(\tO\n4\tO\n.\tO\n2\tO\nand\tO\n8\tO\n.\tO\n5\tO\n%\tO\n)\tO\nand\tO\nsomnolence\tB-Disease\n(\tT-2\n5\tT-2\n.\tT-2\n5\tT-2\nand\tT-2\n2\tT-2\n.\tT-2\n3\tT-2\n%\tT-2\n)\tT-2\n.\tO\n\nSevere\tT-0\nocular\tB-Disease\nand\tI-Disease\norbital\tI-Disease\ntoxicity\tI-Disease\nafter\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tO\nfor\tO\nrecurrent\tO\nglioblastomas\tO\n.\tO\n\nSevere\tO\nocular\tO\nand\tO\norbital\tO\ntoxicity\tO\nafter\tO\nintracarotid\tO\ninjection\tT-1\nof\tT-1\ncarboplatin\tB-Chemical\nfor\tT-0\nrecurrent\tT-0\nglioblastomas\tT-0\n.\tO\n\nSevere\tO\nocular\tO\nand\tO\norbital\tO\ntoxicity\tO\nafter\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tO\nfor\tO\nrecurrent\tT-0\nglioblastomas\tB-Disease\n.\tO\n\nBACKGROUND\tT-0\n:\tT-0\nGlioblastoma\tB-Disease\nis\tT-1\na\tT-1\nmalignant\tT-1\ntumor\tT-1\nthat\tO\noccurs\tO\nin\tO\nthe\tO\ncerebrum\tO\nduring\tO\nadulthood\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nGlioblastoma\tO\nis\tT-1\na\tT-1\nmalignant\tB-Disease\ntumor\tI-Disease\nthat\tO\noccurs\tT-0\nin\tO\nthe\tO\ncerebrum\tO\nduring\tO\nadulthood\tO\n.\tO\n\nTherefore\tO\n,\tO\npatients\tT-0\nwith\tT-0\nglioblastoma\tB-Disease\nsometimes\tO\nhave\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarcinostatics\tO\nadded\tO\nto\tO\nthe\tO\ntreatment\tO\nregimen\tO\n.\tO\n\nGenerally\tT-0\n,\tO\ncarboplatin\tB-Chemical\nis\tO\nsaid\tO\nto\tO\nhave\tO\nmilder\tT-1\nside\tT-1\neffects\tT-1\nthan\tO\ncisplatin\tO\n,\tO\nwhose\tO\nocular\tO\nand\tO\norbital\tO\ntoxicity\tO\nare\tO\nwell\tO\nknown\tO\n.\tO\n\nGenerally\tO\n,\tO\ncarboplatin\tO\nis\tO\nsaid\tO\nto\tO\nhave\tO\nmilder\tO\nside\tT-2\neffects\tT-2\nthan\tO\ncisplatin\tO\n,\tO\nwhose\tT-0\nocular\tB-Disease\nand\tI-Disease\norbital\tI-Disease\ntoxicity\tI-Disease\nare\tT-1\nwell\tT-1\nknown\tT-1\n.\tT-1\n\nHowever\tO\n,\tO\nwe\tO\nexperienced\tO\na\tO\ncase\tT-0\nof\tT-0\nsevere\tT-0\nocular\tB-Disease\nand\tI-Disease\norbital\tI-Disease\ntoxicity\tI-Disease\nafter\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tO\n,\tO\nwhich\tO\nis\tO\ninfrequently\tO\nreported\tO\n.\tO\n\nHowever\tO\n,\tO\nwe\tO\nexperienced\tO\na\tO\ncase\tO\nof\tO\nsevere\tO\nocular\tO\nand\tO\norbital\tO\ntoxicity\tO\nafter\tO\nintracarotid\tO\ninjection\tT-0\nof\tT-0\ncarboplatin\tB-Chemical\n,\tO\nwhich\tO\nis\tO\ninfrequently\tO\nreported\tO\n.\tO\n\nCASE\tO\n:\tO\nA\tO\n58\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nreceived\tO\nan\tO\nintracarotid\tO\ninjection\tT-0\nof\tT-0\ncarboplatin\tB-Chemical\nfor\tO\nrecurrent\tO\nglioblastomas\tO\nin\tO\nhis\tO\nleft\tO\ntemporal\tO\nlobe\tO\n.\tO\n\nCASE\tO\n:\tO\nA\tO\n58\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nman\tO\nreceived\tO\nan\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tO\nfor\tO\nrecurrent\tT-0\nglioblastomas\tB-Disease\nin\tT-1\nhis\tT-1\nleft\tT-1\ntemporal\tT-1\nlobe\tT-1\n.\tT-1\n\nHe\tO\ncomplained\tT-1\nof\tT-1\npain\tB-Disease\nand\tI-Disease\nvisual\tI-Disease\ndisturbance\tI-Disease\nin\tI-Disease\nthe\tI-Disease\nipsilateral\tI-Disease\neye\tI-Disease\n30\tO\nh\tO\nafter\tO\nthe\tO\ninjection\tO\n.\tO\n\nVarious\tO\nocular\tT-0\nsymptoms\tT-0\nand\tO\nfindings\tO\ncaused\tT-1\nby\tT-1\ncarboplatin\tB-Chemical\ntoxicity\tT-2\nwere\tO\nseen\tO\n.\tO\n\nVarious\tO\nocular\tO\nsymptoms\tO\nand\tO\nfindings\tO\ncaused\tT-0\nby\tO\ncarboplatin\tO\ntoxicity\tB-Disease\nwere\tO\nseen\tO\n.\tO\n\nRESULTS\tO\n:\tO\nHe\tO\nwas\tO\ntreated\tT-0\nwith\tT-0\nintravenous\tO\nadministration\tO\nof\tO\ncorticosteroids\tT-2\nand\tO\nglycerin\tB-Chemical\nfor\tO\n6\tO\ndays\tO\nafter\tO\nthe\tO\ninjection\tT-1\n.\tO\n\nAlthough\tO\nthe\tO\nintraocular\tO\npressure\tO\nelevation\tO\ncaused\tT-0\nby\tT-0\nsecondary\tO\nacute\tO\nangle\tO\n-\tO\nclosure\tO\nglaucoma\tB-Disease\ndecreased\tO\nand\tO\nocular\tO\npain\tO\ndiminished\tO\n,\tO\ninexorable\tO\npapilledema\tO\nand\tO\nexudative\tO\nretinal\tO\ndetachment\tO\ncontinued\tO\nfor\tO\n3\tO\nweeks\tO\n.\tO\n\nAlthough\tO\nthe\tO\nintraocular\tO\npressure\tO\nelevation\tO\ncaused\tO\nby\tO\nsecondary\tO\nacute\tO\nangle\tO\n-\tO\nclosure\tO\nglaucoma\tO\ndecreased\tO\nand\tO\nocular\tB-Disease\npain\tI-Disease\ndiminished\tT-0\n,\tO\ninexorable\tO\npapilledema\tO\nand\tO\nexudative\tO\nretinal\tO\ndetachment\tO\ncontinued\tO\nfor\tO\n3\tO\nweeks\tO\n.\tO\n\nAlthough\tO\nthe\tO\nintraocular\tO\npressure\tO\nelevation\tO\ncaused\tO\nby\tO\nsecondary\tO\nacute\tT-1\nangle\tO\n-\tO\nclosure\tO\nglaucoma\tO\ndecreased\tO\nand\tO\nocular\tO\npain\tO\ndiminished\tO\n,\tO\ninexorable\tT-2\npapilledema\tB-Disease\nand\tT-0\nexudative\tT-0\nretinal\tO\ndetachment\tO\ncontinued\tO\nfor\tO\n3\tO\nweeks\tO\n.\tO\n\nAlthough\tO\nthe\tO\nintraocular\tT-1\npressure\tT-1\nelevation\tT-1\ncaused\tO\nby\tO\nsecondary\tO\nacute\tO\nangle\tO\n-\tO\nclosure\tO\nglaucoma\tO\ndecreased\tO\nand\tO\nocular\tO\npain\tO\ndiminished\tO\n,\tO\ninexorable\tO\npapilledema\tO\nand\tO\nexudative\tT-0\nretinal\tB-Disease\ndetachment\tI-Disease\ncontinued\tO\nfor\tO\n3\tO\nweeks\tO\n.\tO\n\nFinally\tO\n,\tO\n6\tO\nweeks\tO\nlater\tO\n,\tO\ndiffuse\tT-2\nchorioretinal\tB-Disease\natrophy\tI-Disease\nwith\tT-1\noptic\tO\natrophy\tO\noccurred\tO\nand\tO\nthe\tO\nvision\tO\nin\tO\nhis\tO\nleft\tO\neye\tO\nwas\tO\nlost\tO\n.\tO\n\nFinally\tO\n,\tO\n6\tO\nweeks\tO\nlater\tO\n,\tO\ndiffuse\tO\nchorioretinal\tO\natrophy\tT-0\nwith\tT-0\noptic\tB-Disease\natrophy\tI-Disease\noccurred\tT-1\nand\tO\nthe\tO\nvision\tO\nin\tO\nhis\tO\nleft\tO\neye\tO\nwas\tO\nlost\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nWhen\tO\nperforming\tO\nintracarotid\tT-0\ninjection\tT-0\nof\tT-0\ncarboplatin\tB-Chemical\n,\tO\nwe\tO\nmust\tO\nbe\tO\naware\tO\nof\tO\nits\tO\npotentially\tO\nblinding\tO\nocular\tO\ntoxicity\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nWhen\tO\nperforming\tO\nintracarotid\tO\ninjection\tO\nof\tO\ncarboplatin\tO\n,\tO\nwe\tO\nmust\tO\nbe\tO\naware\tO\nof\tO\nits\tO\npotentially\tO\nblinding\tT-0\nocular\tB-Disease\ntoxicity\tI-Disease\n.\tO\n\nVisual\tO\nhallucinations\tO\nassociated\tT-0\nwith\tT-0\nzonisamide\tB-Chemical\n.\tO\n\nZonisamide\tB-Chemical\nis\tT-1\na\tT-1\nbroad\tT-1\n-\tO\nspectrum\tO\nantiepileptic\tO\ndrug\tT-0\nused\tO\nto\tO\ntreat\tO\nvarious\tO\ntypes\tO\nof\tO\nseizures\tO\n.\tO\n\nZonisamide\tO\nis\tO\na\tO\nbroad\tO\n-\tO\nspectrum\tO\nantiepileptic\tO\ndrug\tO\nused\tO\nto\tO\ntreat\tO\nvarious\tO\ntypes\tT-0\nof\tT-0\nseizures\tB-Disease\n.\tO\n\nAlthough\tT-0\nvisual\tB-Disease\nhallucinations\tI-Disease\nhave\tT-1\nnot\tT-1\nbeen\tT-1\nreported\tT-1\nas\tO\nan\tO\nadverse\tO\neffect\tO\nof\tO\nthis\tO\nagent\tO\n,\tO\nwe\tO\ndescribe\tO\nthree\tO\npatients\tO\nwho\tO\nexperienced\tO\ncomplex\tO\nvisual\tO\nhallucinations\tO\nand\tO\naltered\tO\nmental\tO\nstatus\tO\nafter\tO\nzonisamide\tO\ntreatment\tO\nwas\tO\nbegun\tO\nor\tO\nits\tO\ndosage\tO\nincreased\tO\n.\tO\n\nAlthough\tO\nvisual\tO\nhallucinations\tO\nhave\tO\nnot\tO\nbeen\tO\nreported\tO\nas\tO\nan\tO\nadverse\tO\neffect\tO\nof\tO\nthis\tO\nagent\tO\n,\tO\nwe\tO\ndescribe\tO\nthree\tO\npatients\tO\nwho\tO\nexperienced\tO\ncomplex\tT-2\nvisual\tB-Disease\nhallucinations\tI-Disease\nand\tO\naltered\tO\nmental\tO\nstatus\tO\nafter\tO\nzonisamide\tO\ntreatment\tT-0\nwas\tT-0\nbegun\tT-0\nor\tO\nits\tO\ndosage\tT-1\nincreased\tT-1\n.\tO\n\nAlthough\tO\nvisual\tO\nhallucinations\tO\nhave\tO\nnot\tO\nbeen\tO\nreported\tO\nas\tO\nan\tO\nadverse\tO\neffect\tO\nof\tO\nthis\tO\nagent\tO\n,\tO\nwe\tO\ndescribe\tO\nthree\tO\npatients\tO\nwho\tO\nexperienced\tO\ncomplex\tO\nvisual\tO\nhallucinations\tO\nand\tO\naltered\tO\nmental\tO\nstatus\tO\nafter\tO\nzonisamide\tB-Chemical\ntreatment\tT-0\nwas\tO\nbegun\tO\nor\tO\nits\tO\ndosage\tT-1\nincreased\tT-1\n.\tO\n\nAll\tO\nthree\tO\nhad\tO\nbeen\tO\ndiagnosed\tT-0\nearlier\tO\nwith\tT-1\nepilepsy\tB-Disease\n,\tO\nand\tO\ntheir\tO\nelectroencephalogram\tO\n(\tO\nEEG\tO\n)\tO\nfindings\tO\nwere\tO\nabnormal\tO\n.\tO\n\nDuring\tT-1\nmonitoring\tT-1\n,\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\ndid\tT-0\nnot\tT-0\ncorrelate\tT-0\nwith\tO\nEEG\tO\nreadings\tO\n,\tO\nnor\tO\ndid\tO\nvideo\tO\nrecording\tO\ncapture\tO\nany\tO\nof\tO\nthe\tO\ndescribed\tO\nevents\tO\n.\tO\n\nNone\tT-0\nof\tT-0\nthe\tT-0\npatients\tT-1\nhad\tT-1\nexperienced\tO\nvisual\tB-Disease\nhallucinations\tI-Disease\nbefore\tO\nthis\tO\nevent\tO\n.\tO\n\nThe\tO\nonly\tO\nrecent\tO\nchange\tO\nin\tO\ntheir\tO\ntreatment\tO\nwas\tO\nthe\tO\nintroduction\tT-0\nor\tO\nincreased\tT-1\ndosage\tT-1\nof\tO\nzonisamide\tB-Chemical\n.\tO\n\nUntil\tO\nthen\tO\n,\tO\nclinicians\tO\nneed\tO\nto\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\npossible\tT-1\ncomplication\tT-1\nassociated\tT-1\nwith\tT-0\nzonisamide\tB-Chemical\n.\tO\n\nAnti\tO\n-\tO\nepileptic\tB-Disease\ndrugs\tO\n-\tO\ninduced\tT-0\nde\tO\nnovo\tO\nabsence\tO\nseizures\tO\n.\tO\n\nAnti\tO\n-\tO\nepileptic\tO\ndrugs\tO\n-\tO\ninduced\tT-0\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizures\tI-Disease\n.\tO\n\nThe\tO\nauthors\tO\npresent\tT-0\nthree\tO\npatients\tT-1\nwith\tT-1\nde\tO\nnovo\tO\nabsence\tB-Disease\nepilepsy\tI-Disease\nafter\tO\nadministration\tT-2\nof\tT-2\ncarbamazepine\tO\nand\tO\nvigabatrin\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\nthree\tO\npatients\tO\nwith\tO\nde\tT-0\nnovo\tT-0\nabsence\tT-0\nepilepsy\tT-0\nafter\tO\nadministration\tT-1\nof\tT-1\ncarbamazepine\tB-Chemical\nand\tO\nvigabatrin\tO\n.\tO\n\nThe\tO\nauthors\tO\npresent\tO\nthree\tO\npatients\tO\nwith\tO\nde\tO\nnovo\tO\nabsence\tO\nepilepsy\tO\nafter\tO\nadministration\tT-0\nof\tT-0\ncarbamazepine\tO\nand\tO\nvigabatrin\tB-Chemical\n.\tO\n\nDespite\tO\nthe\tO\nunderlying\tT-2\ndiseases\tT-2\n,\tO\nthe\tT-3\nprognosis\tT-3\nfor\tO\ndrug\tO\n-\tO\ninduced\tT-0\nde\tT-1\nnovo\tT-1\nabsence\tB-Disease\nseizure\tI-Disease\nis\tO\ngood\tO\nbecause\tO\nit\tO\nsubsides\tO\nrapidly\tO\nafter\tO\ndiscontinuing\tO\nthe\tO\nuse\tO\nof\tO\nthe\tO\noffending\tO\ndrugs\tO\n.\tO\n\nThe\tO\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n-\tO\ntransmitted\tT-0\nthalamocortical\tO\ncircuitry\tO\naccounts\tO\nfor\tO\na\tO\nmajor\tO\npart\tO\nof\tO\nthe\tO\nunderlying\tO\nneurophysiology\tO\nof\tO\nthe\tO\nabsence\tO\nepilepsy\tO\n.\tO\n\nThe\tO\ngamma\tO\n-\tO\naminobutyric\tO\nacid\tO\n-\tO\ntransmitted\tO\nthalamocortical\tO\ncircuitry\tO\naccounts\tO\nfor\tO\na\tO\nmajor\tO\npart\tO\nof\tO\nthe\tT-0\nunderlying\tT-0\nneurophysiology\tT-1\nof\tT-1\nthe\tT-1\nabsence\tB-Disease\nepilepsy\tI-Disease\n.\tO\n\nBecause\tO\ndrug\tT-1\n-\tT-1\ninduced\tT-1\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizure\tI-Disease\nis\tO\nrare\tO\n,\tO\npro\tO\n-\tO\nabsence\tO\ndrugs\tO\ncan\tO\nonly\tO\nbe\tO\nconsidered\tO\na\tO\npromoting\tO\nfactor\tO\n.\tO\n\nThe\tO\nunderlying\tO\nepileptogenecity\tO\nof\tO\nthe\tO\npatients\tT-1\nor\tO\nthe\tO\nsynergistic\tO\neffects\tO\nof\tO\nthe\tO\naccompanying\tO\ndrugs\tO\nis\tO\nrequired\tO\nto\tO\ntrigger\tT-0\nthe\tO\nde\tO\nnovo\tO\nabsence\tB-Disease\nseizure\tI-Disease\n.\tO\n\nThe\tO\npossibility\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tT-0\naggravation\tO\nshould\tO\nbe\tO\nconsidered\tO\nwhenever\tO\nan\tO\nunexpected\tO\nincrease\tT-1\nin\tO\nseizure\tB-Disease\nfrequency\tO\nand\tO\n/\tO\nor\tO\nnew\tO\nseizure\tO\ntypes\tO\nappear\tO\nfollowing\tO\na\tO\nchange\tO\nin\tO\ndrug\tO\ntreatment\tT-2\n.\tO\n\nThe\tO\npossibility\tO\nof\tO\ndrug\tO\n-\tO\ninduced\tO\naggravation\tO\nshould\tO\nbe\tO\nconsidered\tO\nwhenever\tO\nan\tO\nunexpected\tO\nincrease\tT-0\nin\tO\nseizure\tO\nfrequency\tO\nand\tO\n/\tO\nor\tO\nnew\tO\nseizure\tB-Disease\ntypes\tT-1\nappear\tO\nfollowing\tO\na\tO\nchange\tO\nin\tO\ndrug\tO\ntreatment\tO\n.\tO\n\nBy\tO\nunderstanding\tO\nthe\tO\nunderlying\tT-2\nmechanism\tT-2\nof\tT-2\nabsence\tB-Disease\nepilepsy\tI-Disease\n,\tO\nwe\tO\ncan\tO\navoid\tO\nthe\tO\ninappropriate\tO\nuse\tO\nof\tO\nanticonvulsants\tO\nin\tO\nchildren\tO\nwith\tO\nepilepsy\tO\nand\tO\nprevent\tO\ndrug\tO\n-\tO\ninduced\tO\nabsence\tO\nseizures\tO\n.\tO\n\nBy\tO\nunderstanding\tO\nthe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nabsence\tO\nepilepsy\tO\n,\tO\nwe\tO\ncan\tO\navoid\tO\nthe\tO\ninappropriate\tT-1\nuse\tT-1\nof\tO\nanticonvulsants\tO\nin\tO\nchildren\tO\nwith\tO\nepilepsy\tB-Disease\nand\tT-0\nprevent\tT-0\ndrug\tO\n-\tO\ninduced\tT-2\nabsence\tO\nseizures\tO\n.\tO\n\nBy\tO\nunderstanding\tO\nthe\tO\nunderlying\tO\nmechanism\tO\nof\tO\nabsence\tT-0\nepilepsy\tT-0\n,\tO\nwe\tO\ncan\tO\navoid\tO\nthe\tO\ninappropriate\tO\nuse\tO\nof\tO\nanticonvulsants\tO\nin\tO\nchildren\tO\nwith\tO\nepilepsy\tT-1\nand\tO\nprevent\tO\ndrug\tT-2\n-\tT-2\ninduced\tT-2\nabsence\tB-Disease\nseizures\tI-Disease\n.\tO\n\nPrenatal\tT-1\ndexamethasone\tT-1\nprograms\tO\nhypertension\tB-Disease\nand\tO\nrenal\tO\ninjury\tT-0\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nPrenatal\tT-0\ndexamethasone\tO\nprograms\tT-3\nhypertension\tT-1\nand\tT-1\nrenal\tB-Disease\ninjury\tI-Disease\nin\tT-2\nthe\tT-2\nrat\tT-2\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nif\tO\nprenatal\tT-0\ndexamethasone\tB-Chemical\nprogrammed\tT-2\na\tT-2\nprogressive\tT-2\nincrease\tT-2\nin\tO\nblood\tO\npressure\tO\nand\tO\nrenal\tO\ninjury\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nif\tO\nprenatal\tT-0\ndexamethasone\tT-0\nprogrammed\tT-0\na\tT-0\nprogressive\tT-0\nincrease\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nand\tO\nrenal\tT-1\ninjury\tT-1\nin\tT-1\nrats\tT-1\n.\tO\n\nThe\tO\npurpose\tO\nof\tO\nthe\tO\npresent\tO\nstudy\tO\nwas\tO\nto\tO\ndetermine\tO\nif\tO\nprenatal\tO\ndexamethasone\tO\nprogrammed\tO\na\tO\nprogressive\tO\nincrease\tT-0\nin\tO\nblood\tO\npressure\tO\nand\tO\nrenal\tB-Disease\ninjury\tI-Disease\nin\tO\nrats\tO\n.\tO\n\nPregnant\tO\nrats\tO\nwere\tO\ngiven\tO\neither\tO\nvehicle\tO\nor\tO\n2\tO\ndaily\tO\nintraperitoneal\tO\ninjections\tT-1\nof\tT-1\ndexamethasone\tB-Chemical\n(\tO\n0\tO\n.\tO\n2\tO\nmg\tO\n/\tO\nkg\tO\nbody\tO\nweight\tO\n)\tO\non\tT-2\ngestational\tT-2\ndays\tT-2\n11\tO\nand\tO\n12\tO\n,\tO\n13\tO\nand\tO\n14\tO\n,\tO\n15\tO\nand\tO\n16\tO\n,\tO\n17\tO\nand\tO\n18\tO\n,\tO\nor\tO\n19\tO\nand\tO\n20\tO\n.\tO\n\nOffspring\tO\nof\tO\nrats\tO\nadministered\tT-0\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\ngestation\tO\nhad\tO\na\tO\n20\tO\n%\tO\nreduction\tO\nin\tO\nglomerular\tO\nnumber\tO\ncompared\tO\nwith\tO\ncontrol\tO\nat\tO\n6\tO\nto\tO\n9\tO\nmonths\tO\nof\tO\nage\tO\n(\tO\n22\tO\n527\tO\n+\tO\n/\tO\n-\tO\n509\tO\nversus\tO\n28\tO\n050\tO\n+\tO\n/\tO\n-\tO\n561\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nwhich\tO\nwas\tO\ncomparable\tO\nto\tO\nthe\tO\npercent\tO\nreduction\tO\nin\tO\nglomeruli\tO\nmeasured\tO\nat\tO\n3\tO\nweeks\tO\nof\tO\nage\tO\n.\tO\n\nOffspring\tO\nof\tO\nrats\tO\nadministered\tO\ndexamethasone\tO\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\ngestation\tT-1\nhad\tT-1\na\tT-1\n20\tO\n%\tO\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\ncompared\tT-0\nwith\tT-0\ncontrol\tO\nat\tO\n6\tO\nto\tO\n9\tO\nmonths\tO\nof\tO\nage\tO\n(\tO\n22\tO\n527\tO\n+\tO\n/\tO\n-\tO\n509\tO\nversus\tO\n28\tO\n050\tO\n+\tO\n/\tO\n-\tO\n561\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n,\tO\nwhich\tO\nwas\tO\ncomparable\tO\nto\tO\nthe\tO\npercent\tO\nreduction\tO\nin\tO\nglomeruli\tO\nmeasured\tO\nat\tO\n3\tO\nweeks\tO\nof\tO\nage\tO\n.\tO\n\nSix\tO\n-\tO\nto\tO\n9\tO\n-\tO\nmonth\tO\nold\tO\nrats\tO\nreceiving\tO\nprenatal\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n17\tO\nand\tO\n18\tO\nof\tO\ngestation\tO\nhad\tO\na\tO\n17\tO\n%\tO\nreduction\tT-0\nin\tO\nglomeruli\tO\n(\tO\n23\tO\n380\tO\n+\tO\n/\tO\n-\tO\n587\tO\n)\tO\ncompared\tO\nwith\tO\ncontrol\tO\nrats\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nMale\tO\nrats\tO\nthat\tO\nreceived\tT-1\nprenatal\tO\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\n,\tO\n17\tO\nand\tO\n18\tO\n,\tO\nand\tO\n13\tO\nand\tO\n14\tO\nof\tO\ngestation\tO\nhad\tO\nelevated\tT-0\nblood\tT-0\npressures\tT-0\nat\tO\n6\tO\nmonths\tO\nof\tO\nage\tO\n;\tO\nthe\tO\nlatter\tO\ngroup\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nreduction\tT-2\nin\tT-2\nglomerular\tO\nnumber\tO\n.\tO\n\nMale\tO\nrats\tO\nthat\tO\nreceived\tO\nprenatal\tO\ndexamethasone\tO\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\n,\tO\n17\tO\nand\tO\n18\tO\n,\tO\nand\tO\n13\tO\nand\tO\n14\tO\nof\tO\ngestation\tO\nhad\tO\nelevated\tO\nblood\tO\npressures\tO\nat\tO\n6\tO\nmonths\tO\nof\tO\nage\tO\n;\tO\nthe\tO\nlatter\tO\ngroup\tO\ndid\tT-1\nnot\tT-1\nhave\tT-1\na\tT-1\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\n.\tO\n\nAdult\tO\nrats\tO\ngiven\tT-0\ndexamethasone\tB-Chemical\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\nof\tO\ngestation\tO\nhad\tO\nmore\tO\nglomeruli\tO\nwith\tO\nglomerulosclerosis\tO\nthan\tO\ncontrol\tO\nrats\tO\n.\tO\n\nAdult\tO\nrats\tO\ngiven\tT-0\ndexamethasone\tT-0\non\tO\ndays\tO\n15\tO\nand\tO\n16\tO\nof\tO\ngestation\tO\nhad\tT-2\nmore\tT-2\nglomeruli\tT-2\nwith\tT-2\nglomerulosclerosis\tB-Disease\nthan\tO\ncontrol\tO\nrats\tO\n.\tO\n\nThis\tO\nstudy\tO\nshows\tT-1\nthat\tT-1\nprenatal\tT-1\ndexamethasone\tB-Chemical\nin\tT-2\nrats\tT-2\nresults\tT-0\nin\tT-0\na\tO\nreduction\tO\nin\tO\nglomerular\tO\nnumber\tO\n,\tO\nglomerulosclerosis\tO\n,\tO\nand\tO\nhypertension\tO\nwhen\tO\nadministered\tO\nat\tO\nspecific\tO\npoints\tO\nduring\tO\ngestation\tO\n.\tO\n\nThis\tO\nstudy\tO\nshows\tO\nthat\tO\nprenatal\tO\ndexamethasone\tO\nin\tO\nrats\tO\nresults\tT-0\nin\tT-0\na\tT-0\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\n,\tO\nglomerulosclerosis\tO\n,\tO\nand\tO\nhypertension\tO\nwhen\tO\nadministered\tO\nat\tO\nspecific\tO\npoints\tO\nduring\tO\ngestation\tO\n.\tO\n\nThis\tO\nstudy\tO\nshows\tO\nthat\tO\nprenatal\tO\ndexamethasone\tO\nin\tO\nrats\tO\nresults\tT-0\nin\tT-0\na\tT-0\nreduction\tT-0\nin\tT-0\nglomerular\tO\nnumber\tO\n,\tO\nglomerulosclerosis\tB-Disease\n,\tO\nand\tO\nhypertension\tO\nwhen\tO\nadministered\tO\nat\tO\nspecific\tO\npoints\tO\nduring\tO\ngestation\tO\n.\tO\n\nThis\tO\nstudy\tO\nshows\tO\nthat\tO\nprenatal\tO\ndexamethasone\tO\nin\tO\nrats\tO\nresults\tO\nin\tO\na\tO\nreduction\tT-1\nin\tT-1\nglomerular\tO\nnumber\tO\n,\tO\nglomerulosclerosis\tO\n,\tO\nand\tO\nhypertension\tB-Disease\nwhen\tT-2\nadministered\tT-2\nat\tO\nspecific\tO\npoints\tO\nduring\tO\ngestation\tO\n.\tO\n\nHypertension\tB-Disease\nwas\tT-1\nobserved\tT-1\nin\tO\nanimals\tO\nthat\tO\nhad\tO\na\tO\nreduction\tO\nin\tO\nglomeruli\tO\nas\tO\nwell\tO\nas\tO\nin\tO\na\tO\ngroup\tO\nthat\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nreduction\tO\nin\tO\nglomerular\tO\nnumber\tO\n,\tO\nsuggesting\tO\nthat\tO\na\tO\nreduction\tO\nin\tO\nglomerular\tO\nnumber\tO\nis\tO\nnot\tO\nthe\tO\nsole\tT-0\ncause\tT-0\nfor\tT-0\nthe\tT-0\ndevelopment\tT-0\nof\tT-0\nhypertension\tO\n.\tO\n\nHypertension\tO\nwas\tO\nobserved\tO\nin\tO\nanimals\tO\nthat\tO\nhad\tO\na\tO\nreduction\tT-0\nin\tO\nglomeruli\tO\nas\tO\nwell\tO\nas\tO\nin\tO\na\tO\ngroup\tO\nthat\tO\ndid\tT-3\nnot\tT-3\nhave\tT-3\na\tT-3\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\n,\tT-3\nsuggesting\tO\nthat\tO\na\tO\nreduction\tT-1\nin\tO\nglomerular\tO\nnumber\tO\nis\tO\nnot\tO\nthe\tO\nsole\tO\ncause\tO\nfor\tO\nthe\tO\ndevelopment\tT-2\nof\tO\nhypertension\tO\n.\tO\n\nHypertension\tO\nwas\tO\nobserved\tO\nin\tO\nanimals\tO\nthat\tO\nhad\tO\na\tO\nreduction\tO\nin\tO\nglomeruli\tO\nas\tO\nwell\tO\nas\tO\nin\tO\na\tO\ngroup\tO\nthat\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nreduction\tO\nin\tO\nglomerular\tO\nnumber\tO\n,\tO\nsuggesting\tT-0\nthat\tT-2\na\tT-2\nreduction\tB-Disease\nin\tI-Disease\nglomerular\tI-Disease\nnumber\tI-Disease\nis\tT-3\nnot\tT-3\nthe\tT-1\nsole\tT-1\ncause\tT-1\nfor\tO\nthe\tO\ndevelopment\tO\nof\tO\nhypertension\tO\n.\tO\n\nHypertension\tO\nwas\tO\nobserved\tO\nin\tO\nanimals\tO\nthat\tO\nhad\tO\na\tO\nreduction\tO\nin\tO\nglomeruli\tO\nas\tO\nwell\tO\nas\tO\nin\tO\na\tO\ngroup\tO\nthat\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nreduction\tO\nin\tO\nglomerular\tO\nnumber\tO\n,\tO\nsuggesting\tO\nthat\tO\na\tO\nreduction\tO\nin\tO\nglomerular\tO\nnumber\tO\nis\tO\nnot\tO\nthe\tO\nsole\tO\ncause\tO\nfor\tO\nthe\tO\ndevelopment\tT-0\nof\tT-0\nhypertension\tB-Disease\n.\tO\n\nKidney\tO\nfunction\tO\nand\tO\nmorphology\tO\nafter\tO\nshort\tO\n-\tO\nterm\tO\ncombination\tO\ntherapy\tO\nwith\tT-0\ncyclosporine\tB-Chemical\nA\tI-Chemical\n,\tO\ntacrolimus\tO\nand\tO\nsirolimus\tO\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nKidney\tO\nfunction\tO\nand\tO\nmorphology\tO\nafter\tO\nshort\tO\n-\tO\nterm\tO\ncombination\tO\ntherapy\tT-2\nwith\tT-2\ncyclosporine\tT-0\nA\tT-0\n,\tO\ntacrolimus\tB-Chemical\nand\tT-1\nsirolimus\tT-1\nin\tT-1\nthe\tT-1\nrat\tT-1\n.\tO\n\nKidney\tO\nfunction\tO\nand\tO\nmorphology\tO\nafter\tO\nshort\tO\n-\tO\nterm\tO\ncombination\tO\ntherapy\tT-1\nwith\tT-0\ncyclosporine\tT-0\nA\tT-0\n,\tO\ntacrolimus\tO\nand\tO\nsirolimus\tB-Chemical\nin\tO\nthe\tO\nrat\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nSirolimus\tB-Chemical\n(\tO\nSRL\tO\n)\tO\nmay\tT-0\nsupplement\tT-0\ncalcineurin\tO\ninhibitors\tO\nin\tO\nclinical\tO\norgan\tO\ntransplantation\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nSirolimus\tT-0\n(\tO\nSRL\tB-Chemical\n)\tO\nmay\tT-1\nsupplement\tT-1\ncalcineurin\tO\ninhibitors\tO\nin\tO\nclinical\tO\norgan\tO\ntransplantation\tO\n.\tO\n\nThese\tO\nare\tO\nnephrotoxic\tB-Disease\n,\tO\nbut\tO\nSRL\tO\nseems\tO\nto\tO\nact\tT-0\ndifferently\tT-0\ndisplaying\tO\nonly\tO\nminor\tO\nnephrotoxic\tO\neffects\tO\n,\tO\nalthough\tO\nthis\tO\nquestion\tO\nis\tO\nstill\tO\nopen\tO\n.\tO\n\nThese\tO\nare\tO\nnephrotoxic\tO\n,\tO\nbut\tO\nSRL\tB-Chemical\nseems\tT-0\nto\tT-0\nact\tT-0\ndifferently\tO\ndisplaying\tO\nonly\tO\nminor\tO\nnephrotoxic\tO\neffects\tO\n,\tO\nalthough\tO\nthis\tO\nquestion\tO\nis\tO\nstill\tO\nopen\tO\n.\tO\n\nThese\tO\nare\tO\nnephrotoxic\tO\n,\tO\nbut\tO\nSRL\tO\nseems\tO\nto\tO\nact\tO\ndifferently\tO\ndisplaying\tO\nonly\tO\nminor\tT-0\nnephrotoxic\tB-Disease\neffects\tT-1\n,\tO\nalthough\tO\nthis\tO\nquestion\tO\nis\tO\nstill\tO\nopen\tO\n.\tO\n\nIn\tO\na\tO\nnumber\tO\nof\tO\ntreatment\tO\nprotocols\tT-0\nwhere\tT-0\nSRL\tB-Chemical\nwas\tT-1\ncombined\tT-1\nwith\tO\na\tO\ncalcineurin\tO\ninhibitor\tO\nindications\tO\nof\tO\na\tO\nsynergistic\tO\nnephrotoxic\tO\neffect\tO\nwere\tO\ndescribed\tO\n.\tO\n\nIn\tO\na\tO\nnumber\tO\nof\tO\ntreatment\tO\nprotocols\tO\nwhere\tO\nSRL\tO\nwas\tO\ncombined\tO\nwith\tO\na\tO\ncalcineurin\tO\ninhibitor\tO\nindications\tO\nof\tO\na\tO\nsynergistic\tT-0\nnephrotoxic\tB-Disease\neffect\tT-1\nwere\tO\ndescribed\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nfurther\tO\nthe\tO\nrenal\tO\nfunction\tO\n,\tO\nincluding\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nof\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tT-0\nwith\tT-0\neither\tO\ncyclosporine\tB-Chemical\nA\tI-Chemical\n(\tO\nCsA\tO\n)\tO\n,\tO\ntacrolimus\tO\n(\tO\nFK506\tO\n)\tO\nor\tO\nSRL\tO\nas\tO\nmonotherapies\tO\nor\tO\nin\tO\ndifferent\tO\ncombinations\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nfurther\tO\nthe\tO\nrenal\tO\nfunction\tO\n,\tO\nincluding\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nof\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tT-1\nwith\tT-1\neither\tT-1\ncyclosporine\tT-0\nA\tT-0\n(\tT-0\nCsA\tB-Chemical\n)\tO\n,\tO\ntacrolimus\tO\n(\tO\nFK506\tO\n)\tO\nor\tO\nSRL\tO\nas\tO\nmonotherapies\tO\nor\tO\nin\tO\ndifferent\tO\ncombinations\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nfurther\tO\nthe\tO\nrenal\tO\nfunction\tO\n,\tO\nincluding\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nof\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tO\nwith\tO\neither\tT-0\ncyclosporine\tT-0\nA\tT-0\n(\tT-0\nCsA\tT-0\n)\tT-0\n,\tO\ntacrolimus\tB-Chemical\n(\tT-1\nFK506\tT-1\n)\tT-1\nor\tO\nSRL\tO\nas\tO\nmonotherapies\tO\nor\tO\nin\tO\ndifferent\tO\ncombinations\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nfurther\tO\nthe\tO\nrenal\tO\nfunction\tO\n,\tO\nincluding\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nof\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tT-0\nwith\tT-0\neither\tO\ncyclosporine\tO\nA\tO\n(\tO\nCsA\tO\n)\tO\n,\tO\ntacrolimus\tO\n(\tO\nFK506\tB-Chemical\n)\tO\nor\tO\nSRL\tO\nas\tT-1\nmonotherapies\tT-1\nor\tO\nin\tO\ndifferent\tO\ncombinations\tO\n.\tO\n\nMETHODS\tO\n:\tO\nFor\tO\na\tO\nperiod\tO\nof\tO\n2\tO\nweeks\tO\n,\tO\nCsA\tO\n15\tT-0\nmg\tT-0\n/\tT-0\nkg\tT-0\n/\tT-0\nday\tT-0\n(\tO\ngiven\tO\norally\tO\n)\tO\n,\tO\nFK506\tB-Chemical\n3\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tT-1\norally\tT-1\n)\tO\nor\tO\nSRL\tO\n0\tO\n.\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\nintraperitoneally\tO\n)\tO\nwas\tO\nadministered\tO\nonce\tO\na\tO\nday\tO\nas\tO\nthese\tO\ndoses\tO\nhave\tO\nearlier\tO\nbeen\tO\nfound\tO\nto\tO\nachieve\tO\na\tO\nsignificant\tO\nimmunosuppressive\tO\neffect\tO\nin\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\n.\tO\n\nMETHODS\tO\n:\tO\nFor\tO\na\tO\nperiod\tO\nof\tO\n2\tO\nweeks\tO\n,\tO\nCsA\tO\n15\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\norally\tO\n)\tO\n,\tO\nFK506\tO\n3\tO\n.\tO\n0\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\norally\tO\n)\tO\nor\tT-0\nSRL\tB-Chemical\n0\tO\n.\tO\n4\tO\nmg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\n(\tO\ngiven\tO\nintraperitoneally\tO\n)\tO\nwas\tT-1\nadministered\tT-1\nonce\tO\na\tO\nday\tO\nas\tO\nthese\tO\ndoses\tO\nhave\tO\nearlier\tO\nbeen\tO\nfound\tO\nto\tO\nachieve\tO\na\tO\nsignificant\tO\nimmunosuppressive\tO\neffect\tO\nin\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\n.\tO\n\nThe\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nincluded\tO\na\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nsystem\tO\nanalysing\tO\nthe\tO\ndegree\tT-2\nof\tT-2\nstriped\tT-0\nfibrosis\tB-Disease\n,\tO\nsubcapsular\tT-1\nfibrosis\tT-1\nand\tO\nthe\tO\nnumber\tO\nof\tO\nbasophilic\tO\ntubules\tO\n,\tO\nplus\tO\nan\tO\nadditional\tO\nstereological\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tO\ngrade\tO\nof\tO\nfibrosis\tO\nin\tO\nthe\tO\ncortex\tO\nstained\tO\nwith\tO\nSirius\tO\nRed\tO\n.\tO\n\nThe\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nincluded\tO\na\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nsystem\tO\nanalysing\tO\nthe\tO\ndegree\tO\nof\tO\nstriped\tO\nfibrosis\tO\n,\tO\nsubcapsular\tT-0\nfibrosis\tB-Disease\nand\tO\nthe\tO\nnumber\tO\nof\tO\nbasophilic\tO\ntubules\tO\n,\tO\nplus\tO\nan\tO\nadditional\tO\nstereological\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tO\ngrade\tO\nof\tO\nfibrosis\tO\nin\tO\nthe\tO\ncortex\tO\nstained\tO\nwith\tO\nSirius\tO\nRed\tO\n.\tO\n\nThe\tO\nmorphological\tO\nanalysis\tO\nof\tO\nthe\tO\nkidneys\tO\nincluded\tO\na\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nsystem\tO\nanalysing\tO\nthe\tO\ndegree\tO\nof\tO\nstriped\tO\nfibrosis\tO\n,\tO\nsubcapsular\tO\nfibrosis\tO\nand\tO\nthe\tO\nnumber\tO\nof\tO\nbasophilic\tO\ntubules\tO\n,\tO\nplus\tO\nan\tO\nadditional\tO\nstereological\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tT-0\ngrade\tT-0\nof\tT-0\nfibrosis\tB-Disease\nin\tT-1\nthe\tT-1\ncortex\tT-1\nstained\tO\nwith\tO\nSirius\tO\nRed\tO\n.\tO\n\nRESULTS\tO\n:\tO\nCsA\tB-Chemical\n,\tO\nFK506\tO\nand\tO\nSRL\tO\nall\tT-1\nsignificantly\tT-1\ndecreased\tT-1\nthe\tT-0\nGFR\tT-0\n.\tO\n\nRESULTS\tO\n:\tO\nCsA\tT-2\n,\tO\nFK506\tB-Chemical\nand\tT-1\nSRL\tT-3\nall\tT-3\nsignificantly\tT-3\ndecreased\tT-3\nthe\tT-3\nGFR\tT-3\n.\tO\n\nRESULTS\tO\n:\tO\nCsA\tO\n,\tO\nFK506\tO\nand\tO\nSRL\tB-Chemical\nall\tO\nsignificantly\tT-0\ndecreased\tT-0\nthe\tT-0\nGFR\tT-0\n.\tO\n\nA\tO\nfurther\tO\ndeterioration\tT-1\nwas\tT-1\nseen\tT-1\nwhen\tT-1\nCsA\tB-Chemical\nwas\tT-2\ncombined\tT-2\nwith\tT-2\neither\tO\nFK506\tO\nor\tO\nSRL\tO\n,\tO\nwhereas\tO\nthe\tO\nGFR\tO\nremained\tO\nunchanged\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nFK506\tO\nplus\tO\nSRL\tO\nwhen\tO\ncompared\tO\nwith\tO\ntreatment\tO\nwith\tO\nany\tO\nof\tO\nthe\tO\nsingle\tO\nsubstances\tO\n.\tO\n\nA\tO\nfurther\tO\ndeterioration\tO\nwas\tO\nseen\tO\nwhen\tO\nCsA\tO\nwas\tO\ncombined\tT-0\nwith\tT-0\neither\tO\nFK506\tB-Chemical\nor\tO\nSRL\tO\n,\tO\nwhereas\tO\nthe\tO\nGFR\tO\nremained\tO\nunchanged\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nFK506\tO\nplus\tO\nSRL\tO\nwhen\tO\ncompared\tO\nwith\tO\ntreatment\tO\nwith\tO\nany\tO\nof\tO\nthe\tO\nsingle\tO\nsubstances\tO\n.\tO\n\nA\tO\nfurther\tO\ndeterioration\tO\nwas\tO\nseen\tO\nwhen\tO\nCsA\tO\nwas\tO\ncombined\tO\nwith\tO\neither\tO\nFK506\tO\nor\tO\nSRL\tB-Chemical\n,\tO\nwhereas\tO\nthe\tO\nGFR\tO\nremained\tO\nunchanged\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nFK506\tO\nplus\tO\nSRL\tO\nwhen\tO\ncompared\tO\nwith\tO\ntreatment\tO\nwith\tO\nany\tT-0\nof\tT-0\nthe\tT-0\nsingle\tT-0\nsubstances\tT-0\n.\tO\n\nA\tO\nfurther\tO\ndeterioration\tO\nwas\tO\nseen\tO\nwhen\tO\nCsA\tO\nwas\tO\ncombined\tO\nwith\tO\neither\tO\nFK506\tO\nor\tO\nSRL\tO\n,\tO\nwhereas\tO\nthe\tO\nGFR\tO\nremained\tO\nunchanged\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tT-0\nwith\tT-0\nFK506\tB-Chemical\nplus\tO\nSRL\tO\nwhen\tO\ncompared\tO\nwith\tO\ntreatment\tO\nwith\tO\nany\tO\nof\tO\nthe\tO\nsingle\tO\nsubstances\tO\n.\tO\n\nA\tO\nfurther\tO\ndeterioration\tO\nwas\tO\nseen\tO\nwhen\tO\nCsA\tO\nwas\tO\ncombined\tO\nwith\tO\neither\tO\nFK506\tO\nor\tO\nSRL\tO\n,\tO\nwhereas\tO\nthe\tO\nGFR\tO\nremained\tO\nunchanged\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tT-1\nwith\tT-1\nFK506\tO\nplus\tO\nSRL\tB-Chemical\nwhen\tO\ncompared\tO\nwith\tO\ntreatment\tT-2\nwith\tT-2\nany\tT-2\nof\tT-2\nthe\tT-2\nsingle\tT-2\nsubstances\tT-2\n.\tO\n\nThe\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nwas\tO\nsignificantly\tO\nworst\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tT-0\nwith\tT-0\nCsA\tB-Chemical\nplus\tO\nSRL\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\ncompared\tO\nwith\tO\ncontrols\tO\n)\tO\nand\tO\nthe\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tO\ngrade\tO\nof\tO\nfibrosis\tO\nalso\tO\nshowed\tO\nthe\tO\nhighest\tO\nproportion\tO\nin\tO\nthe\tO\nsame\tO\ngroup\tO\nand\tO\nwas\tO\nsignificantly\tO\ndifferent\tO\nfrom\tO\ncontrols\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nThe\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nwas\tO\nsignificantly\tO\nworst\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tT-0\nwith\tT-0\nCsA\tO\nplus\tO\nSRL\tB-Chemical\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\ncompared\tO\nwith\tO\ncontrols\tO\n)\tO\nand\tO\nthe\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tO\ngrade\tO\nof\tO\nfibrosis\tO\nalso\tO\nshowed\tO\nthe\tO\nhighest\tO\nproportion\tO\nin\tO\nthe\tO\nsame\tO\ngroup\tO\nand\tO\nwas\tO\nsignificantly\tO\ndifferent\tO\nfrom\tO\ncontrols\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nThe\tO\nsemi\tO\n-\tO\nquantitative\tO\nscoring\tO\nwas\tO\nsignificantly\tO\nworst\tO\nin\tO\nthe\tO\ngroup\tO\ntreated\tO\nwith\tO\nCsA\tO\nplus\tO\nSRL\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n001\tO\ncompared\tO\nwith\tO\ncontrols\tO\n)\tO\nand\tO\nthe\tO\nanalysis\tO\nof\tO\nthe\tO\ntotal\tT-1\ngrade\tT-1\nof\tT-1\nfibrosis\tB-Disease\nalso\tO\nshowed\tO\nthe\tO\nhighest\tO\nproportion\tO\nin\tO\nthe\tO\nsame\tO\ngroup\tO\nand\tO\nwas\tO\nsignificantly\tO\ndifferent\tO\nfrom\tO\ncontrols\tO\n(\tO\nP\tO\n<\tO\n0\tO\n.\tO\n02\tO\n)\tO\n.\tO\n\nThe\tT-0\nFK506\tB-Chemical\nplus\tT-1\nSRL\tT-1\ncombination\tT-1\nshowed\tT-2\nonly\tT-2\na\tO\nmarginally\tO\nhigher\tO\ndegree\tO\nof\tO\nfibrosis\tO\nas\tO\ncompared\tO\nwith\tO\ncontrols\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\nFK506\tO\nplus\tT-0\nSRL\tB-Chemical\ncombination\tT-1\nshowed\tO\nonly\tO\na\tO\nmarginally\tO\nhigher\tO\ndegree\tO\nof\tO\nfibrosis\tO\nas\tO\ncompared\tO\nwith\tO\ncontrols\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nThe\tO\nFK506\tO\nplus\tO\nSRL\tO\ncombination\tO\nshowed\tO\nonly\tO\na\tO\nmarginally\tO\nhigher\tT-0\ndegree\tT-1\nof\tT-1\nfibrosis\tB-Disease\nas\tO\ncompared\tO\nwith\tO\ncontrols\tO\n(\tO\nP\tO\n=\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nrat\tO\nstudy\tO\ndemonstrated\tO\na\tT-0\nsynergistic\tT-0\nnephrotoxic\tB-Disease\neffect\tO\nof\tO\nCsA\tO\nplus\tO\nSRL\tO\n,\tO\nwhereas\tO\nFK506\tO\nplus\tO\nSRL\tO\nwas\tO\nbetter\tO\ntolerated\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nrat\tO\nstudy\tO\ndemonstrated\tO\na\tO\nsynergistic\tT-0\nnephrotoxic\tT-0\neffect\tT-1\nof\tT-1\nCsA\tB-Chemical\nplus\tO\nSRL\tO\n,\tO\nwhereas\tO\nFK506\tO\nplus\tO\nSRL\tO\nwas\tO\nbetter\tO\ntolerated\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nrat\tO\nstudy\tO\ndemonstrated\tO\na\tO\nsynergistic\tO\nnephrotoxic\tO\neffect\tT-0\nof\tT-0\nCsA\tO\nplus\tO\nSRL\tB-Chemical\n,\tO\nwhereas\tO\nFK506\tO\nplus\tO\nSRL\tO\nwas\tO\nbetter\tO\ntolerated\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nrat\tO\nstudy\tO\ndemonstrated\tO\na\tO\nsynergistic\tO\nnephrotoxic\tO\neffect\tT-2\nof\tO\nCsA\tO\nplus\tO\nSRL\tO\n,\tO\nwhereas\tT-0\nFK506\tB-Chemical\nplus\tT-1\nSRL\tT-1\nwas\tO\nbetter\tO\ntolerated\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThis\tO\nrat\tO\nstudy\tO\ndemonstrated\tO\na\tO\nsynergistic\tO\nnephrotoxic\tO\neffect\tO\nof\tO\nCsA\tO\nplus\tO\nSRL\tO\n,\tO\nwhereas\tO\nFK506\tO\nplus\tO\nSRL\tB-Chemical\nwas\tO\nbetter\tT-0\ntolerated\tT-0\n.\tO\n\nEvaluation\tO\nof\tO\ncardiac\tO\ntroponin\tO\nI\tO\nand\tO\nT\tO\nlevels\tO\nas\tO\nmarkers\tT-0\nof\tT-0\nmyocardial\tB-Disease\ndamage\tI-Disease\nin\tT-1\ndoxorubicin\tO\n-\tO\ninduced\tO\ncardiomyopathy\tO\nrats\tO\n,\tO\nand\tO\ntheir\tO\nrelationship\tO\nwith\tO\nechocardiographic\tO\nand\tO\nhistological\tO\nfindings\tO\n.\tO\n\nEvaluation\tO\nof\tO\ncardiac\tO\ntroponin\tO\nI\tO\nand\tO\nT\tO\nlevels\tO\nas\tO\nmarkers\tO\nof\tO\nmyocardial\tO\ndamage\tT-0\nin\tT-0\ndoxorubicin\tB-Chemical\n-\tO\ninduced\tO\ncardiomyopathy\tO\nrats\tO\n,\tO\nand\tO\ntheir\tO\nrelationship\tO\nwith\tO\nechocardiographic\tO\nand\tO\nhistological\tO\nfindings\tO\n.\tO\n\nEvaluation\tO\nof\tO\ncardiac\tO\ntroponin\tO\nI\tO\nand\tO\nT\tO\nlevels\tO\nas\tO\nmarkers\tO\nof\tO\nmyocardial\tO\ndamage\tT-2\nin\tT-2\ndoxorubicin\tT-2\n-\tT-2\ninduced\tT-2\ncardiomyopathy\tB-Disease\nrats\tT-1\n,\tO\nand\tO\ntheir\tO\nrelationship\tO\nwith\tO\nechocardiographic\tO\nand\tO\nhistological\tO\nfindings\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCardiac\tO\ntroponins\tO\nI\tO\n(\tO\ncTnI\tO\n)\tO\nand\tO\nT\tO\n(\tO\ncTnT\tO\n)\tO\nhave\tO\nbeen\tO\nshown\tO\nto\tO\nbe\tO\nhighly\tO\nsensitive\tO\nand\tO\nspecific\tT-1\nmarkers\tT-1\nof\tT-1\nmyocardial\tB-Disease\ncell\tI-Disease\ninjury\tI-Disease\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\ndiagnostic\tO\nvalue\tT-0\nof\tT-0\ncTnI\tO\nand\tO\ncTnT\tO\nfor\tO\nthe\tO\ndiagnosis\tO\nof\tO\nmyocardial\tB-Disease\ndamage\tI-Disease\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tO\ncardiomyopathy\tO\n,\tO\nand\tO\nwe\tO\nexamined\tO\nthe\tO\nrelationship\tO\nbetween\tO\nserial\tO\ncTnI\tO\nand\tO\ncTnT\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\ncardiac\tO\ndisorders\tO\nmonitored\tO\nby\tO\nechocardiography\tO\nand\tO\nhistological\tO\nexaminations\tO\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\ndiagnostic\tO\nvalue\tO\nof\tO\ncTnI\tO\nand\tO\ncTnT\tO\nfor\tO\nthe\tO\ndiagnosis\tO\nof\tO\nmyocardial\tO\ndamage\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\ndoxorubicin\tB-Chemical\n(\tT-0\nDOX\tT-0\n)\tT-0\n-\tO\ninduced\tT-1\ncardiomyopathy\tT-1\n,\tO\nand\tO\nwe\tO\nexamined\tO\nthe\tO\nrelationship\tO\nbetween\tO\nserial\tO\ncTnI\tO\nand\tO\ncTnT\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\ncardiac\tO\ndisorders\tO\nmonitored\tO\nby\tO\nechocardiography\tO\nand\tO\nhistological\tO\nexaminations\tO\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\ndiagnostic\tT-2\nvalue\tT-2\nof\tT-2\ncTnI\tT-2\nand\tT-2\ncTnT\tT-2\nfor\tO\nthe\tO\ndiagnosis\tO\nof\tO\nmyocardial\tT-0\ndamage\tT-0\nin\tT-0\na\tT-0\nrat\tT-0\nmodel\tT-0\nof\tT-0\ndoxorubicin\tT-0\n(\tO\nDOX\tB-Chemical\n)\tO\n-\tO\ninduced\tT-1\ncardiomyopathy\tT-1\n,\tO\nand\tO\nwe\tO\nexamined\tO\nthe\tO\nrelationship\tO\nbetween\tO\nserial\tO\ncTnI\tO\nand\tO\ncTnT\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\ncardiac\tO\ndisorders\tO\nmonitored\tO\nby\tO\nechocardiography\tO\nand\tO\nhistological\tO\nexaminations\tO\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\ndiagnostic\tT-0\nvalue\tT-0\nof\tO\ncTnI\tO\nand\tO\ncTnT\tO\nfor\tO\nthe\tO\ndiagnosis\tT-1\nof\tT-1\nmyocardial\tT-1\ndamage\tO\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tT-3\ncardiomyopathy\tB-Disease\n,\tO\nand\tO\nwe\tO\nexamined\tO\nthe\tO\nrelationship\tO\nbetween\tO\nserial\tO\ncTnI\tO\nand\tO\ncTnT\tO\nwith\tO\nthe\tO\ndevelopment\tO\nof\tO\ncardiac\tO\ndisorders\tO\nmonitored\tO\nby\tO\nechocardiography\tO\nand\tO\nhistological\tT-2\nexaminations\tT-2\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nWe\tO\ninvestigated\tO\nthe\tO\ndiagnostic\tT-0\nvalue\tT-0\nof\tT-0\ncTnI\tO\nand\tO\ncTnT\tO\nfor\tO\nthe\tO\ndiagnosis\tT-1\nof\tT-1\nmyocardial\tT-1\ndamage\tT-1\nin\tO\na\tO\nrat\tO\nmodel\tO\nof\tO\ndoxorubicin\tO\n(\tO\nDOX\tO\n)\tO\n-\tO\ninduced\tO\ncardiomyopathy\tO\n,\tO\nand\tO\nwe\tO\nexamined\tO\nthe\tO\nrelationship\tO\nbetween\tO\nserial\tO\ncTnI\tO\nand\tO\ncTnT\tO\nwith\tO\nthe\tO\ndevelopment\tT-3\nof\tT-3\ncardiac\tB-Disease\ndisorders\tI-Disease\nmonitored\tO\nby\tO\nechocardiography\tO\nand\tO\nhistological\tT-2\nexaminations\tT-2\nin\tO\nthis\tO\nmodel\tO\n.\tO\n\nMETHODS\tO\n:\tO\nThirty\tO\n-\tO\nfive\tO\nWistar\tO\nrats\tO\nwere\tT-1\ngiven\tT-1\n1\tT-0\n.\tT-0\n5\tT-0\nmg\tT-0\n/\tT-0\nkg\tT-0\nDOX\tB-Chemical\n,\tO\ni\tO\n.\tO\nv\tO\n.\tO\n,\tO\nweekly\tO\nfor\tO\nup\tO\nto\tO\n8\tO\nweeks\tO\nfor\tO\na\tO\ntotal\tO\ncumulative\tO\ndose\tO\nof\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nBW\tO\n.\tO\n\nBy\tO\nusing\tO\ntransthoracic\tO\nechocardiography\tO\n,\tO\nanterior\tO\nand\tO\nposterior\tO\nwall\tO\nthickness\tO\n,\tO\nLV\tO\ndiameters\tO\nand\tO\nLV\tO\nfractional\tO\nshortening\tO\n(\tO\nFS\tO\n)\tO\nwere\tO\nmeasured\tO\nin\tO\nall\tO\nrats\tO\nbefore\tT-0\nDOX\tB-Chemical\nor\tT-1\nsaline\tT-1\n,\tO\nand\tO\nat\tO\nweeks\tO\n6\tO\nand\tO\n9\tO\nafter\tO\ntreatment\tO\nin\tO\nall\tO\nsurviving\tO\nrats\tO\n.\tO\n\nHistology\tO\nwas\tO\nperformed\tO\nin\tO\nDOX\tO\n-\tO\nrats\tO\nat\tO\n6\tO\nand\tO\n9\tO\nweeks\tO\nafter\tT-0\nthe\tT-0\nlast\tT-0\nDOX\tB-Chemical\ndose\tT-1\nand\tT-1\nin\tT-1\nall\tT-1\ncontrols\tT-1\n.\tT-1\n\nRESULTS\tO\n:\tO\nEighteen\tO\nof\tO\nthe\tO\nDOX\tB-Chemical\nrats\tO\ndied\tO\nprematurely\tO\nof\tO\ngeneral\tO\ntoxicity\tT-0\nduring\tO\nthe\tO\n9\tO\n-\tO\nweek\tO\nperiod\tO\n.\tO\n\nRESULTS\tO\n:\tO\nEighteen\tO\nof\tO\nthe\tO\nDOX\tO\nrats\tO\ndied\tO\nprematurely\tO\nof\tO\ngeneral\tT-0\ntoxicity\tB-Disease\nduring\tO\nthe\tO\n9\tO\n-\tO\nweek\tO\nperiod\tO\n.\tO\n\nEnd\tO\n-\tO\ndiastolic\tO\n(\tO\nED\tO\n)\tO\nand\tO\nend\tO\n-\tO\nsystolic\tO\n(\tO\nES\tO\n)\tO\nLV\tO\ndiameters\tO\n/\tO\nBW\tO\nsignificantly\tO\nincreased\tO\n,\tO\nwhereas\tO\nLV\tO\nFS\tO\nwas\tO\ndecreased\tO\nafter\tO\n9\tO\nweeks\tO\nin\tO\nthe\tO\nDOX\tB-Chemical\ngroup\tT-0\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n001\tO\n)\tO\n.\tO\n\nHistological\tO\nevaluation\tO\nof\tO\nhearts\tO\nfrom\tO\nall\tO\nrats\tO\ngiven\tT-0\nDOX\tB-Chemical\nrevealed\tT-1\nsignificant\tT-1\nslight\tT-1\ndegrees\tO\nof\tO\nperivascular\tO\nand\tO\ninterstitial\tO\nfibrosis\tO\n.\tO\n\nHistological\tO\nevaluation\tO\nof\tO\nhearts\tO\nfrom\tO\nall\tO\nrats\tO\ngiven\tO\nDOX\tO\nrevealed\tO\nsignificant\tO\nslight\tO\ndegrees\tO\nof\tO\nperivascular\tO\nand\tO\ninterstitial\tT-0\nfibrosis\tB-Disease\n.\tO\n\nOnly\tO\nfive\tO\nof\tO\nthe\tO\ncontrols\tO\nexhibited\tO\nevidence\tO\nof\tO\nvery\tO\nslight\tO\nperivascular\tT-0\nfibrosis\tB-Disease\n.\tO\n\nA\tO\nsignificant\tO\nrise\tO\nin\tO\ncTnT\tO\nwas\tO\nfound\tT-1\nin\tT-1\nDOX\tB-Chemical\nrats\tT-0\nafter\tT-0\ncumulative\tT-0\ndoses\tT-0\nof\tO\n7\tO\n.\tO\n5\tO\nand\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nin\tO\ncomparison\tO\nwith\tO\nbaseline\tO\n(\tO\np\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\ncTnT\tO\nfound\tO\nin\tO\nrats\tO\nafter\tO\n12\tO\nmg\tO\n/\tO\nkg\tO\nwere\tO\nsignificantly\tO\ngreater\tO\nthan\tO\nthat\tO\nfound\tT-0\nafter\tT-0\n7\tO\n.\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nDOX\tB-Chemical\n.\tO\n\nMaximal\tO\ncTnI\tO\n(\tO\npg\tO\n/\tO\nml\tO\n)\tO\nand\tO\ncTnT\tO\nlevels\tO\nwere\tO\nsignificantly\tO\nincreased\tO\nin\tT-0\nDOX\tB-Chemical\nrats\tO\ncompared\tO\nwith\tO\ncontrols\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n006\tO\n,\tO\n0\tO\n.\tO\n007\tO\n)\tO\n.\tT-0\n\ncTnI\tO\n(\tO\nng\tO\n/\tO\nml\tO\n)\tO\n,\tO\nCK\tO\n-\tO\nMB\tO\nmass\tO\nand\tO\nCK\tO\nremained\tT-1\nunchanged\tT-1\nin\tT-0\nDOX\tB-Chemical\nrats\tO\ncompared\tO\nwith\tO\ncontrols\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAmong\tT-1\nmarkers\tT-1\nof\tT-1\nischemic\tB-Disease\ninjury\tI-Disease\nafter\tO\nDOX\tT-0\nin\tO\nrats\tO\n,\tO\ncTnT\tO\nshowed\tO\nthe\tO\ngreatest\tO\nability\tO\nto\tO\ndetect\tO\nmyocardial\tO\ndamage\tO\nassessed\tO\nby\tO\nechocardiographic\tO\ndetection\tO\nand\tO\nhistological\tO\nchanges\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAmong\tO\nmarkers\tO\nof\tO\nischemic\tT-1\ninjury\tT-1\nafter\tT-0\nDOX\tB-Chemical\nin\tO\nrats\tO\n,\tO\ncTnT\tO\nshowed\tO\nthe\tO\ngreatest\tO\nability\tO\nto\tO\ndetect\tO\nmyocardial\tO\ndamage\tO\nassessed\tO\nby\tO\nechocardiographic\tO\ndetection\tO\nand\tO\nhistological\tO\nchanges\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nAmong\tO\nmarkers\tO\nof\tO\nischemic\tO\ninjury\tO\nafter\tO\nDOX\tO\nin\tO\nrats\tO\n,\tO\ncTnT\tO\nshowed\tO\nthe\tO\ngreatest\tO\nability\tO\nto\tT-1\ndetect\tT-1\nmyocardial\tB-Disease\ndamage\tI-Disease\nassessed\tO\nby\tO\nechocardiographic\tT-0\ndetection\tT-0\nand\tO\nhistological\tO\nchanges\tO\n.\tO\n\nAlthough\tO\nthere\tO\nwas\tO\na\tO\ndiscrepancy\tO\nbetween\tO\nthe\tO\namount\tO\nof\tO\ncTnI\tO\nand\tO\ncTnT\tO\nafter\tT-0\nDOX\tB-Chemical\n,\tO\nprobably\tT-1\ndue\tT-1\nto\tT-1\nheterogeneity\tT-1\nin\tT-1\ncross\tT-1\n-\tO\nreactivities\tO\nof\tO\nmAbs\tO\nto\tO\nvarious\tO\ncTnI\tO\nand\tO\ncTnT\tO\nforms\tO\n,\tO\nit\tO\nis\tO\nlikely\tO\nthat\tO\ncTnT\tO\nin\tO\nrats\tO\nafter\tO\nDOX\tO\nindicates\tO\ncell\tO\ndamage\tO\ndetermined\tO\nby\tO\nthe\tO\nmagnitude\tO\nof\tO\ninjury\tO\ninduced\tO\nand\tO\nthat\tO\ncTnT\tO\nshould\tO\nbe\tO\na\tO\nuseful\tO\nmarker\tO\nfor\tO\nthe\tO\nprediction\tO\nof\tO\nexperimentally\tO\ninduced\tO\ncardiotoxicity\tO\nand\tO\npossibly\tO\nfor\tO\ncardioprotective\tO\nexperiments\tO\n.\tO\n\nAlthough\tO\nthere\tO\nwas\tO\na\tO\ndiscrepancy\tO\nbetween\tO\nthe\tO\namount\tO\nof\tO\ncTnI\tO\nand\tO\ncTnT\tO\nafter\tO\nDOX\tO\n,\tO\nprobably\tO\ndue\tO\nto\tO\nheterogeneity\tO\nin\tO\ncross\tO\n-\tO\nreactivities\tT-1\nof\tO\nmAbs\tO\nto\tO\nvarious\tO\ncTnI\tO\nand\tO\ncTnT\tO\nforms\tO\n,\tO\nit\tO\nis\tO\nlikely\tO\nthat\tO\ncTnT\tO\nin\tO\nrats\tO\nafter\tO\nDOX\tB-Chemical\nindicates\tT-3\ncell\tO\ndamage\tO\ndetermined\tO\nby\tO\nthe\tO\nmagnitude\tO\nof\tO\ninjury\tO\ninduced\tT-2\nand\tO\nthat\tO\ncTnT\tO\nshould\tO\nbe\tO\na\tO\nuseful\tT-0\nmarker\tT-0\nfor\tO\nthe\tO\nprediction\tO\nof\tO\nexperimentally\tO\ninduced\tO\ncardiotoxicity\tO\nand\tO\npossibly\tO\nfor\tO\ncardioprotective\tO\nexperiments\tO\n.\tO\n\nAlthough\tO\nthere\tO\nwas\tO\na\tO\ndiscrepancy\tO\nbetween\tO\nthe\tO\namount\tO\nof\tO\ncTnI\tO\nand\tO\ncTnT\tO\nafter\tO\nDOX\tO\n,\tO\nprobably\tO\ndue\tO\nto\tO\nheterogeneity\tO\nin\tO\ncross\tO\n-\tO\nreactivities\tO\nof\tO\nmAbs\tO\nto\tO\nvarious\tO\ncTnI\tO\nand\tO\ncTnT\tO\nforms\tO\n,\tO\nit\tO\nis\tO\nlikely\tO\nthat\tO\ncTnT\tO\nin\tO\nrats\tO\nafter\tO\nDOX\tO\nindicates\tO\ncell\tO\ndamage\tO\ndetermined\tO\nby\tO\nthe\tO\nmagnitude\tO\nof\tO\ninjury\tO\ninduced\tO\nand\tO\nthat\tO\ncTnT\tO\nshould\tO\nbe\tO\na\tO\nuseful\tO\nmarker\tO\nfor\tO\nthe\tO\nprediction\tO\nof\tO\nexperimentally\tT-0\ninduced\tT-0\ncardiotoxicity\tB-Disease\nand\tO\npossibly\tO\nfor\tO\ncardioprotective\tO\nexperiments\tO\n.\tO\n\nOctreotide\tB-Chemical\n-\tO\ninduced\tT-0\nhypoxemia\tO\nand\tO\npulmonary\tO\nhypertension\tO\nin\tO\npremature\tO\nneonates\tO\n.\tO\n\nOctreotide\tO\n-\tO\ninduced\tT-0\nhypoxemia\tB-Disease\nand\tO\npulmonary\tO\nhypertension\tO\nin\tO\npremature\tO\nneonates\tO\n.\tO\n\nOctreotide\tO\n-\tO\ninduced\tT-1\nhypoxemia\tO\nand\tO\npulmonary\tB-Disease\nhypertension\tI-Disease\nin\tO\npremature\tT-0\nneonates\tT-0\n.\tO\n\nThe\tO\nauthors\tO\nreport\tO\n2\tO\ncases\tT-0\nof\tT-0\npremature\tO\nneonates\tO\nwho\tO\nhad\tO\nenterocutaneous\tT-2\nfistula\tB-Disease\ncomplicating\tT-1\nnecrotizing\tO\nenterocolitis\tO\n.\tO\n\nThe\tO\nauthors\tO\nreport\tO\n2\tO\ncases\tO\nof\tO\npremature\tO\nneonates\tO\nwho\tO\nhad\tO\nenterocutaneous\tO\nfistula\tO\ncomplicating\tT-0\nnecrotizing\tB-Disease\nenterocolitis\tI-Disease\n.\tO\n\nPulmonary\tB-Disease\nhypertension\tI-Disease\ndeveloped\tT-0\nafter\tO\nadministration\tO\nof\tO\na\tO\nsomatostatin\tO\nanalogue\tO\n,\tO\noctreotide\tO\n,\tO\nto\tO\nenhance\tO\nresolution\tO\nof\tO\nthe\tO\nfistula\tO\n.\tO\n\nPulmonary\tO\nhypertension\tO\ndeveloped\tO\nafter\tO\nadministration\tO\nof\tO\na\tO\nsomatostatin\tO\nanalogue\tO\n,\tO\noctreotide\tB-Chemical\n,\tO\nto\tO\nenhance\tT-0\nresolution\tT-0\nof\tT-0\nthe\tT-0\nfistula\tT-0\n.\tO\n\nPulmonary\tT-0\nhypertension\tT-0\ndeveloped\tO\nafter\tO\nadministration\tO\nof\tO\na\tO\nsomatostatin\tO\nanalogue\tO\n,\tO\noctreotide\tO\n,\tO\nto\tO\nenhance\tO\nresolution\tT-1\nof\tT-1\nthe\tT-1\nfistula\tB-Disease\n.\tO\n\nThe\tO\nrisk\tT-0\nof\tT-0\nvenous\tB-Disease\nthromboembolism\tI-Disease\nin\tO\nwomen\tO\nprescribed\tO\ncyproterone\tO\nacetate\tO\nin\tO\ncombination\tO\nwith\tO\nethinyl\tO\nestradiol\tO\n:\tO\na\tO\nnested\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nvenous\tO\nthromboembolism\tO\nin\tO\nwomen\tO\nprescribed\tT-1\ncyproterone\tB-Chemical\nacetate\tI-Chemical\nin\tO\ncombination\tO\nwith\tO\nethinyl\tO\nestradiol\tO\n:\tO\na\tO\nnested\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\n.\tO\n\nThe\tO\nrisk\tO\nof\tO\nvenous\tO\nthromboembolism\tO\nin\tO\nwomen\tO\nprescribed\tO\ncyproterone\tO\nacetate\tO\nin\tO\ncombination\tO\nwith\tO\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n:\tO\na\tO\nnested\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tT-0\n-\tT-0\ncontrol\tT-0\nstudy\tT-0\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tB-Chemical\nacetate\tI-Chemical\ncombined\tO\nwith\tO\nethinyl\tO\nestradiol\tO\n(\tO\nCPA\tO\n/\tO\nEE\tO\n)\tO\nis\tO\nlicensed\tT-0\nin\tO\nthe\tO\nUK\tO\nfor\tT-1\nthe\tT-1\ntreatment\tT-1\nof\tO\nwomen\tO\nwith\tO\nacne\tO\nand\tO\nhirsutism\tO\nand\tO\nis\tO\nalso\tO\na\tO\ntreatment\tO\noption\tO\nfor\tO\npolycystic\tO\novary\tO\nsyndrome\tO\n(\tO\nPCOS\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tT-0\nacetate\tT-0\ncombined\tT-1\nwith\tT-1\nethinyl\tB-Chemical\nestradiol\tI-Chemical\n(\tO\nCPA\tO\n/\tO\nEE\tO\n)\tO\nis\tO\nlicensed\tT-2\nin\tT-2\nthe\tO\nUK\tO\nfor\tT-3\nthe\tT-3\ntreatment\tT-3\nof\tO\nwomen\tO\nwith\tO\nacne\tO\nand\tO\nhirsutism\tO\nand\tO\nis\tO\nalso\tO\na\tO\ntreatment\tO\noption\tO\nfor\tO\npolycystic\tO\novary\tO\nsyndrome\tO\n(\tO\nPCOS\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tO\nacetate\tO\ncombined\tT-0\nwith\tT-0\nethinyl\tT-1\nestradiol\tT-1\n(\tO\nCPA\tB-Chemical\n/\tO\nEE\tO\n)\tO\nis\tT-2\nlicensed\tT-2\nin\tO\nthe\tO\nUK\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nwomen\tO\nwith\tO\nacne\tO\nand\tO\nhirsutism\tO\nand\tO\nis\tO\nalso\tO\na\tO\ntreatment\tO\noption\tO\nfor\tO\npolycystic\tO\novary\tO\nsyndrome\tO\n(\tO\nPCOS\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tO\nacetate\tO\ncombined\tT-0\nwith\tT-0\nethinyl\tO\nestradiol\tO\n(\tO\nCPA\tO\n/\tO\nEE\tB-Chemical\n)\tO\nis\tO\nlicensed\tO\nin\tO\nthe\tO\nUK\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nwomen\tO\nwith\tO\nacne\tO\nand\tO\nhirsutism\tO\nand\tO\nis\tO\nalso\tO\na\tO\ntreatment\tO\noption\tO\nfor\tO\npolycystic\tO\novary\tO\nsyndrome\tO\n(\tO\nPCOS\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tO\nacetate\tO\ncombined\tO\nwith\tO\nethinyl\tO\nestradiol\tO\n(\tO\nCPA\tO\n/\tO\nEE\tO\n)\tO\nis\tO\nlicensed\tO\nin\tO\nthe\tO\nUK\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nwomen\tT-0\nwith\tT-0\nacne\tB-Disease\nand\tT-1\nhirsutism\tT-1\nand\tO\nis\tO\nalso\tO\na\tO\ntreatment\tO\noption\tO\nfor\tO\npolycystic\tO\novary\tO\nsyndrome\tO\n(\tO\nPCOS\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tO\nacetate\tO\ncombined\tO\nwith\tO\nethinyl\tO\nestradiol\tO\n(\tO\nCPA\tO\n/\tO\nEE\tO\n)\tO\nis\tO\nlicensed\tO\nin\tO\nthe\tO\nUK\tO\nfor\tO\nthe\tO\ntreatment\tT-2\nof\tO\nwomen\tT-0\nwith\tT-0\nacne\tT-0\nand\tT-0\nhirsutism\tB-Disease\nand\tT-1\nis\tT-1\nalso\tT-1\na\tT-1\ntreatment\tT-1\noption\tT-1\nfor\tO\npolycystic\tO\novary\tO\nsyndrome\tO\n(\tO\nPCOS\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tO\nacetate\tO\ncombined\tO\nwith\tO\nethinyl\tO\nestradiol\tO\n(\tO\nCPA\tO\n/\tO\nEE\tO\n)\tO\nis\tO\nlicensed\tO\nin\tO\nthe\tO\nUK\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nwomen\tO\nwith\tO\nacne\tO\nand\tO\nhirsutism\tO\nand\tO\nis\tO\nalso\tO\na\tO\ntreatment\tO\noption\tO\nfor\tT-0\npolycystic\tB-Disease\novary\tI-Disease\nsyndrome\tI-Disease\n(\tO\nPCOS\tO\n)\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nCyproterone\tO\nacetate\tO\ncombined\tO\nwith\tO\nethinyl\tO\nestradiol\tO\n(\tO\nCPA\tO\n/\tO\nEE\tO\n)\tO\nis\tO\nlicensed\tO\nin\tO\nthe\tO\nUK\tO\nfor\tO\nthe\tO\ntreatment\tO\nof\tO\nwomen\tO\nwith\tO\nacne\tO\nand\tO\nhirsutism\tO\nand\tO\nis\tO\nalso\tO\na\tO\ntreatment\tT-0\noption\tO\nfor\tO\npolycystic\tO\novary\tO\nsyndrome\tO\n(\tO\nPCOS\tB-Disease\n)\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tT-0\nof\tT-0\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tO\nVTE\tO\n)\tO\nassociated\tT-1\nwith\tT-1\nCPA\tO\n/\tO\nEE\tO\ncompared\tO\nwith\tO\nconventional\tO\ncombined\tO\noral\tO\ncontraceptives\tO\n(\tO\nCOCs\tO\n)\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tT-1\nrisk\tT-1\nof\tT-1\nvenous\tT-1\nthromboembolism\tT-1\n(\tO\nVTE\tB-Disease\n)\tO\nassociated\tT-0\nwith\tT-0\nCPA\tT-0\n/\tO\nEE\tO\ncompared\tO\nwith\tO\nconventional\tO\ncombined\tO\noral\tO\ncontraceptives\tO\n(\tO\nCOCs\tO\n)\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tO\n)\tO\nassociated\tT-0\nwith\tT-0\nCPA\tB-Chemical\n/\tO\nEE\tO\ncompared\tO\nwith\tO\nconventional\tO\ncombined\tO\noral\tO\ncontraceptives\tO\n(\tO\nCOCs\tO\n)\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tO\n)\tO\nassociated\tT-0\nwith\tT-0\nCPA\tO\n/\tO\nEE\tB-Chemical\ncompared\tO\nwith\tO\nconventional\tO\ncombined\tO\noral\tO\ncontraceptives\tO\n(\tO\nCOCs\tO\n)\tO\n.\tO\n\nPrevious\tO\nstudies\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tO\n)\tO\nassociated\tO\nwith\tO\nCPA\tO\n/\tO\nEE\tO\ncompared\tO\nwith\tO\nconventional\tT-1\ncombined\tT-1\noral\tB-Chemical\ncontraceptives\tI-Chemical\n(\tO\nCOCs\tO\n)\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nthe\tO\nGeneral\tO\nPractice\tO\nResearch\tO\nDatabase\tO\nwe\tO\nconducted\tO\na\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nnested\tO\nwithin\tO\na\tO\npopulation\tO\nof\tO\nwomen\tO\naged\tO\nbetween\tT-0\n15\tT-0\nand\tT-0\n39\tT-0\nyears\tT-0\nwith\tT-0\nacne\tB-Disease\n,\tO\nhirsutism\tT-1\nor\tT-1\nPCOS\tT-1\nto\tO\nestimate\tO\nthe\tO\nrisk\tO\nof\tO\nVTE\tO\nassociated\tO\nwith\tO\nCPA\tO\n/\tO\nEE\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nthe\tO\nGeneral\tT-2\nPractice\tT-2\nResearch\tT-2\nDatabase\tT-2\nwe\tO\nconducted\tO\na\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tT-0\nstudy\tT-0\nnested\tO\nwithin\tO\na\tO\npopulation\tO\nof\tO\nwomen\tO\naged\tO\nbetween\tO\n15\tO\nand\tO\n39\tO\nyears\tO\nwith\tO\nacne\tO\n,\tO\nhirsutism\tB-Disease\nor\tO\nPCOS\tO\nto\tO\nestimate\tO\nthe\tO\nrisk\tT-1\nof\tT-1\nVTE\tO\nassociated\tO\nwith\tO\nCPA\tO\n/\tO\nEE\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nthe\tO\nGeneral\tO\nPractice\tO\nResearch\tO\nDatabase\tO\nwe\tO\nconducted\tO\na\tO\ncohort\tT-0\nanalysis\tT-0\nand\tT-0\ncase\tT-0\n-\tT-0\ncontrol\tT-0\nstudy\tT-0\nnested\tO\nwithin\tO\na\tO\npopulation\tO\nof\tO\nwomen\tO\naged\tO\nbetween\tO\n15\tO\nand\tO\n39\tO\nyears\tO\nwith\tO\nacne\tO\n,\tO\nhirsutism\tO\nor\tO\nPCOS\tB-Disease\nto\tT-2\nestimate\tT-2\nthe\tT-1\nrisk\tT-1\nof\tO\nVTE\tO\nassociated\tO\nwith\tO\nCPA\tO\n/\tO\nEE\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nthe\tO\nGeneral\tO\nPractice\tO\nResearch\tO\nDatabase\tO\nwe\tO\nconducted\tO\na\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nnested\tO\nwithin\tO\na\tO\npopulation\tO\nof\tO\nwomen\tO\naged\tO\nbetween\tO\n15\tO\nand\tO\n39\tO\nyears\tO\nwith\tO\nacne\tO\n,\tO\nhirsutism\tO\nor\tO\nPCOS\tO\nto\tO\nestimate\tO\nthe\tO\nrisk\tT-0\nof\tO\nVTE\tB-Disease\nassociated\tO\nwith\tO\nCPA\tO\n/\tO\nEE\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nthe\tO\nGeneral\tO\nPractice\tO\nResearch\tO\nDatabase\tO\nwe\tO\nconducted\tO\na\tO\ncohort\tO\nanalysis\tO\nand\tO\ncase\tO\n-\tO\ncontrol\tO\nstudy\tO\nnested\tO\nwithin\tO\na\tO\npopulation\tO\nof\tO\nwomen\tO\naged\tO\nbetween\tO\n15\tO\nand\tO\n39\tO\nyears\tO\nwith\tO\nacne\tO\n,\tO\nhirsutism\tO\nor\tO\nPCOS\tO\nto\tO\nestimate\tO\nthe\tO\nrisk\tO\nof\tO\nVTE\tO\nassociated\tT-0\nwith\tT-0\nCPA\tB-Chemical\n/\tO\nEE\tO\n.\tO\n\nMETHODS\tO\n:\tO\nUsing\tO\nthe\tO\nGeneral\tO\nPractice\tO\nResearch\tO\nDatabase\tO\nwe\tO\nconducted\tO\na\tO\ncohort\tT-1\nanalysis\tT-1\nand\tT-1\ncase\tT-1\n-\tO\ncontrol\tO\nstudy\tO\nnested\tO\nwithin\tO\na\tO\npopulation\tO\nof\tO\nwomen\tO\naged\tO\nbetween\tT-2\n15\tT-2\nand\tT-2\n39\tT-2\nyears\tT-2\nwith\tT-2\nacne\tT-2\n,\tO\nhirsutism\tO\nor\tO\nPCOS\tO\nto\tO\nestimate\tO\nthe\tO\nrisk\tO\nof\tO\nVTE\tO\nassociated\tT-0\nwith\tT-0\nCPA\tO\n/\tO\nEE\tB-Chemical\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nage\tO\n-\tO\nadjusted\tO\nincidence\tO\nrate\tO\nratio\tT-1\nfor\tT-0\nCPA\tB-Chemical\n/\tO\nEE\tO\nversus\tT-2\nconventional\tO\nCOCs\tO\nwas\tO\n2\tO\n.\tO\n20\tO\n[\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n(\tO\nCI\tO\n)\tO\n1\tO\n.\tO\n35\tO\n-\tO\n3\tO\n.\tO\n58\tO\n]\tO\n.\tO\n\nRESULTS\tO\n:\tO\nThe\tO\nage\tO\n-\tO\nadjusted\tO\nincidence\tO\nrate\tO\nratio\tT-0\nfor\tT-0\nCPA\tO\n/\tO\nEE\tB-Chemical\nversus\tO\nconventional\tO\nCOCs\tO\nwas\tO\n2\tO\n.\tO\n20\tO\n[\tO\n95\tO\n%\tO\nconfidence\tO\ninterval\tO\n(\tO\nCI\tO\n)\tO\n1\tO\n.\tO\n35\tO\n-\tO\n3\tO\n.\tO\n58\tO\n]\tO\n.\tO\n\nUsing\tO\nas\tO\nthe\tO\nreference\tO\ngroup\tO\nwomen\tO\nwho\tO\nwere\tO\nnot\tO\nusing\tO\noral\tO\ncontraception\tO\n,\tO\nhad\tO\nno\tO\nrecent\tO\npregnancy\tO\nor\tO\nmenopausal\tO\nsymptoms\tO\n,\tO\nthe\tO\ncase\tO\n-\tO\ncontrol\tO\nanalysis\tO\ngave\tO\nan\tO\nadjusted\tO\nodds\tO\nratio\tO\n(\tO\nOR\tO\n(\tO\nadj\tO\n)\tO\n)\tO\nof\tO\n7\tO\n.\tO\n44\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n3\tO\n.\tO\n67\tO\n-\tO\n15\tO\n.\tO\n08\tO\n)\tO\nfor\tT-2\nCPA\tB-Chemical\n/\tO\nEE\tO\nuse\tT-1\ncompared\tO\nwith\tO\nan\tO\nOR\tO\n(\tO\nadj\tO\n)\tO\nof\tO\n2\tO\n.\tO\n58\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n60\tO\n-\tO\n4\tO\n.\tO\n18\tO\n)\tO\nfor\tO\nuse\tO\nof\tO\nconventional\tO\nCOCs\tO\n.\tO\n\nUsing\tO\nas\tO\nthe\tO\nreference\tO\ngroup\tO\nwomen\tO\nwho\tO\nwere\tO\nnot\tO\nusing\tO\noral\tO\ncontraception\tO\n,\tO\nhad\tO\nno\tO\nrecent\tO\npregnancy\tO\nor\tO\nmenopausal\tO\nsymptoms\tO\n,\tO\nthe\tO\ncase\tO\n-\tO\ncontrol\tO\nanalysis\tO\ngave\tO\nan\tO\nadjusted\tT-0\nodds\tT-0\nratio\tT-0\n(\tO\nOR\tO\n(\tO\nadj\tO\n)\tO\n)\tO\nof\tO\n7\tO\n.\tO\n44\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n3\tO\n.\tO\n67\tO\n-\tO\n15\tO\n.\tO\n08\tO\n)\tO\nfor\tO\nCPA\tO\n/\tO\nEE\tB-Chemical\nuse\tO\ncompared\tO\nwith\tO\nan\tO\nOR\tO\n(\tO\nadj\tO\n)\tO\nof\tO\n2\tO\n.\tO\n58\tO\n(\tO\n95\tO\n%\tO\nCI\tO\n1\tO\n.\tO\n60\tO\n-\tO\n4\tO\n.\tO\n18\tO\n)\tO\nfor\tO\nuse\tO\nof\tO\nconventional\tO\nCOCs\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tT-0\nrisk\tT-0\nof\tT-0\nVTE\tB-Disease\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nCPA\tO\n/\tO\nEE\tO\nin\tO\nwomen\tO\nwith\tO\nacne\tO\n,\tO\nhirsutism\tO\nor\tO\nPCOS\tO\nalthough\tO\nresidual\tO\nconfounding\tO\nby\tO\nindication\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nVTE\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tT-0\nof\tT-0\nCPA\tB-Chemical\n/\tO\nEE\tO\nin\tO\nwomen\tO\nwith\tO\nacne\tO\n,\tO\nhirsutism\tO\nor\tO\nPCOS\tO\nalthough\tO\nresidual\tO\nconfounding\tO\nby\tO\nindication\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nVTE\tO\nassociated\tO\nwith\tO\nthe\tT-0\nuse\tT-0\nof\tT-0\nCPA\tO\n/\tO\nEE\tB-Chemical\nin\tO\nwomen\tO\nwith\tO\nacne\tO\n,\tO\nhirsutism\tO\nor\tO\nPCOS\tO\nalthough\tO\nresidual\tO\nconfounding\tO\nby\tO\nindication\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nVTE\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tT-1\nof\tT-1\nCPA\tO\n/\tO\nEE\tO\nin\tO\nwomen\tO\nwith\tO\nacne\tB-Disease\n,\tO\nhirsutism\tO\nor\tO\nPCOS\tO\nalthough\tO\nresidual\tO\nconfounding\tT-0\nby\tT-0\nindication\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tT-0\nrisk\tT-0\nof\tT-0\nVTE\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nCPA\tO\n/\tO\nEE\tO\nin\tO\nwomen\tO\nwith\tO\nacne\tO\n,\tO\nhirsutism\tB-Disease\nor\tO\nPCOS\tO\nalthough\tO\nresidual\tO\nconfounding\tO\nby\tO\nindication\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nWe\tO\nhave\tO\ndemonstrated\tO\nan\tO\nincreased\tO\nrisk\tO\nof\tO\nVTE\tO\nassociated\tO\nwith\tO\nthe\tO\nuse\tO\nof\tO\nCPA\tO\n/\tO\nEE\tO\nin\tO\nwomen\tO\nwith\tO\nacne\tO\n,\tO\nhirsutism\tO\nor\tT-1\nPCOS\tB-Disease\nalthough\tT-0\nresidual\tO\nconfounding\tO\nby\tO\nindication\tO\ncannot\tO\nbe\tO\nexcluded\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\ntreatment\tT-0\nwith\tT-0\ngum\tB-Chemical\nArabic\tI-Chemical\non\tO\ngentamicin\tT-1\nnephrotoxicity\tT-1\nin\tT-1\nrats\tT-1\n:\tO\na\tO\npreliminary\tO\nstudy\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\ntreatment\tT-0\nwith\tT-0\ngum\tT-2\nArabic\tT-2\non\tT-2\ngentamicin\tB-Chemical\nnephrotoxicity\tT-3\nin\tO\nrats\tO\n:\tO\na\tO\npreliminary\tO\nstudy\tO\n.\tO\n\nThe\tO\neffect\tT-1\nof\tT-1\ntreatment\tT-1\nwith\tO\ngum\tO\nArabic\tO\non\tO\ngentamicin\tO\nnephrotoxicity\tB-Disease\nin\tO\nrats\tO\n:\tO\na\tO\npreliminary\tO\nstudy\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nwork\tO\nwe\tO\nassessed\tO\nthe\tO\neffect\tT-0\nof\tT-0\ntreatment\tT-0\nof\tO\nrats\tT-2\nwith\tT-3\ngum\tB-Chemical\nArabic\tI-Chemical\non\tO\nacute\tO\nrenal\tO\nfailure\tO\ninduced\tO\nby\tO\ngentamicin\tO\n(\tO\nGM\tO\n)\tO\nnephrotoxicity\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nwork\tO\nwe\tO\nassessed\tO\nthe\tO\neffect\tO\nof\tO\ntreatment\tT-0\nof\tO\nrats\tO\nwith\tO\ngum\tO\nArabic\tO\non\tO\nacute\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\ninduced\tT-1\nby\tO\ngentamicin\tO\n(\tO\nGM\tO\n)\tO\nnephrotoxicity\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nwork\tO\nwe\tO\nassessed\tO\nthe\tO\neffect\tO\nof\tO\ntreatment\tO\nof\tO\nrats\tO\nwith\tO\ngum\tO\nArabic\tO\non\tO\nacute\tO\nrenal\tO\nfailure\tO\ninduced\tT-0\nby\tT-0\ngentamicin\tB-Chemical\n(\tT-1\nGM\tT-1\n)\tT-1\nnephrotoxicity\tO\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nwork\tO\nwe\tO\nassessed\tO\nthe\tO\neffect\tO\nof\tO\ntreatment\tO\nof\tO\nrats\tO\nwith\tO\ngum\tO\nArabic\tO\non\tO\nacute\tO\nrenal\tO\nfailure\tO\ninduced\tT-0\nby\tT-0\ngentamicin\tT-0\n(\tO\nGM\tB-Chemical\n)\tO\nnephrotoxicity\tT-1\n.\tO\n\nIn\tO\nthe\tO\npresent\tO\nwork\tO\nwe\tO\nassessed\tO\nthe\tO\neffect\tO\nof\tO\ntreatment\tO\nof\tO\nrats\tO\nwith\tO\ngum\tO\nArabic\tO\non\tO\nacute\tO\nrenal\tO\nfailure\tO\ninduced\tT-0\nby\tT-0\ngentamicin\tO\n(\tO\nGM\tO\n)\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nRats\tO\nwere\tO\ntreated\tT-1\nwith\tT-1\nthe\tO\nvehicle\tO\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\ndistilled\tO\nwater\tO\nand\tO\n5\tO\n%\tO\nw\tO\n/\tO\nv\tO\ncellulose\tO\n,\tO\n10\tO\ndays\tO\n)\tO\n,\tO\ngum\tB-Chemical\nArabic\tI-Chemical\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\na\tO\n10\tO\n%\tO\nw\tO\n/\tO\nv\tO\naqueous\tO\nsuspension\tO\nof\tO\ngum\tO\nArabic\tO\npowder\tO\n,\tO\norally\tO\nfor\tO\n10\tO\ndays\tO\n)\tO\n,\tO\nor\tO\ngum\tO\nArabic\tO\nconcomitantly\tO\nwith\tO\nGM\tO\n(\tO\n80mg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nintramuscularly\tO\n,\tO\nduring\tO\nthe\tO\nlast\tO\nsix\tO\ndays\tO\nof\tO\nthe\tO\ntreatment\tO\nperiod\tO\n)\tO\n.\tO\n\nRats\tO\nwere\tO\ntreated\tO\nwith\tO\nthe\tO\nvehicle\tO\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\ndistilled\tO\nwater\tO\nand\tO\n5\tO\n%\tO\nw\tO\n/\tO\nv\tO\ncellulose\tO\n,\tO\n10\tO\ndays\tO\n)\tO\n,\tO\ngum\tO\nArabic\tO\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\na\tO\n10\tO\n%\tO\nw\tO\n/\tO\nv\tO\naqueous\tT-0\nsuspension\tT-0\nof\tT-0\ngum\tB-Chemical\nArabic\tI-Chemical\npowder\tT-1\n,\tO\norally\tO\nfor\tO\n10\tO\ndays\tO\n)\tO\n,\tO\nor\tO\ngum\tO\nArabic\tO\nconcomitantly\tO\nwith\tO\nGM\tO\n(\tO\n80mg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nintramuscularly\tO\n,\tO\nduring\tO\nthe\tO\nlast\tO\nsix\tO\ndays\tO\nof\tO\nthe\tO\ntreatment\tO\nperiod\tO\n)\tO\n.\tO\n\nRats\tO\nwere\tO\ntreated\tT-1\nwith\tO\nthe\tO\nvehicle\tO\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\ndistilled\tO\nwater\tO\nand\tO\n5\tO\n%\tO\nw\tO\n/\tO\nv\tO\ncellulose\tO\n,\tO\n10\tO\ndays\tO\n)\tO\n,\tO\ngum\tO\nArabic\tO\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\na\tO\n10\tO\n%\tO\nw\tO\n/\tO\nv\tO\naqueous\tO\nsuspension\tO\nof\tO\ngum\tO\nArabic\tO\npowder\tO\n,\tO\norally\tO\nfor\tO\n10\tO\ndays\tO\n)\tO\n,\tO\nor\tO\ngum\tB-Chemical\nArabic\tI-Chemical\nconcomitantly\tT-0\nwith\tT-0\nGM\tT-0\n(\tO\n80mg\tO\n/\tO\nkg\tO\n/\tO\nday\tO\nintramuscularly\tO\n,\tO\nduring\tO\nthe\tO\nlast\tO\nsix\tO\ndays\tO\nof\tO\nthe\tO\ntreatment\tO\nperiod\tO\n)\tO\n.\tO\n\nRats\tO\nwere\tO\ntreated\tO\nwith\tO\nthe\tO\nvehicle\tO\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\ndistilled\tO\nwater\tO\nand\tO\n5\tO\n%\tO\nw\tO\n/\tO\nv\tO\ncellulose\tT-0\n,\tO\n10\tO\ndays\tO\n)\tO\n,\tO\ngum\tO\nArabic\tO\n(\tO\n2\tO\nmL\tO\n/\tO\nkg\tO\nof\tO\na\tO\n10\tO\n%\tO\nw\tO\n/\tO\nv\tO\naqueous\tT-1\nsuspension\tT-1\nof\tO\ngum\tO\nArabic\tO\npowder\tO\n,\tO\norally\tO\nfor\tO\n10\tO\ndays\tO\n)\tO\n,\tO\nor\tO\ngum\tO\nArabic\tO\nconcomitantly\tO\nwith\tO\nGM\tB-Chemical\n(\tO\n80mg\tT-2\n/\tT-2\nkg\tT-2\n/\tT-2\nday\tT-2\nintramuscularly\tO\n,\tO\nduring\tO\nthe\tO\nlast\tO\nsix\tO\ndays\tO\nof\tO\nthe\tO\ntreatment\tO\nperiod\tO\n)\tO\n.\tO\n\nNephrotoxicity\tB-Disease\nwas\tT-0\nassessed\tT-0\nby\tO\nmeasuring\tO\nthe\tO\nconcentrations\tO\nof\tO\ncreatinine\tO\nand\tO\nurea\tO\nin\tO\nthe\tO\nplasma\tO\nand\tO\nreduced\tO\nglutathione\tO\n(\tO\nGSH\tO\n)\tO\nin\tO\nthe\tO\nkidney\tO\ncortex\tO\n,\tO\nand\tO\nby\tO\nlight\tO\nmicroscopic\tO\nexamination\tO\nof\tO\nkidney\tO\nsections\tO\n.\tO\n\nNephrotoxicity\tO\nwas\tO\nassessed\tO\nby\tO\nmeasuring\tO\nthe\tO\nconcentrations\tT-1\nof\tT-1\ncreatinine\tB-Chemical\nand\tT-2\nurea\tT-2\nin\tO\nthe\tO\nplasma\tO\nand\tO\nreduced\tO\nglutathione\tO\n(\tO\nGSH\tO\n)\tO\nin\tO\nthe\tO\nkidney\tO\ncortex\tO\n,\tO\nand\tO\nby\tO\nlight\tO\nmicroscopic\tO\nexamination\tO\nof\tO\nkidney\tO\nsections\tO\n.\tO\n\nNephrotoxicity\tO\nwas\tO\nassessed\tT-0\nby\tO\nmeasuring\tT-1\nthe\tO\nconcentrations\tT-2\nof\tO\ncreatinine\tO\nand\tO\nurea\tB-Chemical\nin\tO\nthe\tO\nplasma\tO\nand\tO\nreduced\tO\nglutathione\tO\n(\tO\nGSH\tO\n)\tO\nin\tO\nthe\tO\nkidney\tO\ncortex\tO\n,\tO\nand\tO\nby\tO\nlight\tO\nmicroscopic\tO\nexamination\tO\nof\tO\nkidney\tO\nsections\tO\n.\tO\n\nNephrotoxicity\tO\nwas\tO\nassessed\tO\nby\tO\nmeasuring\tO\nthe\tO\nconcentrations\tO\nof\tO\ncreatinine\tO\nand\tO\nurea\tO\nin\tO\nthe\tO\nplasma\tO\nand\tO\nreduced\tT-0\nglutathione\tB-Chemical\n(\tO\nGSH\tO\n)\tO\nin\tT-1\nthe\tT-1\nkidney\tO\ncortex\tO\n,\tO\nand\tO\nby\tO\nlight\tO\nmicroscopic\tO\nexamination\tO\nof\tO\nkidney\tO\nsections\tO\n.\tO\n\nNephrotoxicity\tO\nwas\tO\nassessed\tO\nby\tO\nmeasuring\tO\nthe\tO\nconcentrations\tO\nof\tO\ncreatinine\tO\nand\tO\nurea\tO\nin\tO\nthe\tO\nplasma\tO\nand\tO\nreduced\tO\nglutathione\tT-0\n(\tO\nGSH\tB-Chemical\n)\tO\nin\tT-1\nthe\tT-1\nkidney\tT-1\ncortex\tT-1\n,\tO\nand\tO\nby\tO\nlight\tO\nmicroscopic\tO\nexamination\tO\nof\tO\nkidney\tO\nsections\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tT-1\nwith\tO\ngum\tB-Chemical\nArabic\tI-Chemical\nand\tO\nGM\tO\nsignificantly\tT-0\nincreased\tT-0\ncreatinine\tO\nand\tO\nurea\tO\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tT-2\nwith\tO\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tO\nGM\tO\n-\tO\ninduced\tO\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tO\ntogether\tO\nwith\tO\ngum\tO\nArabic\tO\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tO\nand\tO\ncellulose\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ngum\tT-1\nArabic\tT-1\nand\tT-1\nGM\tB-Chemical\nsignificantly\tT-2\nincreased\tT-2\ncreatinine\tT-2\nand\tT-2\nurea\tT-2\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tO\nGM\tO\n-\tO\ninduced\tO\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tO\ntogether\tO\nwith\tO\ngum\tO\nArabic\tO\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tO\nand\tO\ncellulose\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ngum\tO\nArabic\tO\nand\tO\nGM\tO\nsignificantly\tO\nincreased\tO\ncreatinine\tO\nand\tO\nurea\tB-Chemical\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tT-0\nwith\tT-0\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tO\nGM\tO\n-\tO\ninduced\tO\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tO\ntogether\tO\nwith\tO\ngum\tO\nArabic\tO\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tO\nand\tO\ncellulose\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tT-0\ntreatment\tT-0\nwith\tO\ngum\tO\nArabic\tO\nand\tO\nGM\tO\nsignificantly\tO\nincreased\tO\ncreatinine\tO\nand\tO\nurea\tO\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tB-Chemical\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tO\nGM\tO\n-\tO\ninduced\tT-1\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tO\ntogether\tO\nwith\tO\ngum\tO\nArabic\tO\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tO\nand\tO\ncellulose\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ngum\tO\nArabic\tO\nand\tO\nGM\tO\nsignificantly\tO\nincreased\tO\ncreatinine\tO\nand\tO\nurea\tO\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tT-0\ncortical\tT-0\nGSH\tB-Chemical\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tO\nGM\tO\n-\tO\ninduced\tO\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tO\ntogether\tO\nwith\tO\ngum\tO\nArabic\tO\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tO\nand\tO\ncellulose\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ngum\tO\nArabic\tO\nand\tO\nGM\tO\nsignificantly\tO\nincreased\tO\ncreatinine\tO\nand\tO\nurea\tO\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tT-1\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tT-0\nthe\tT-0\ncellulose\tT-0\nplus\tT-0\nGM\tB-Chemical\ngroup\tO\n)\tO\nThe\tO\nGM\tO\n-\tO\ninduced\tO\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tO\ntogether\tO\nwith\tO\ngum\tO\nArabic\tO\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tO\nand\tO\ncellulose\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tT-0\ntreatment\tT-0\nwith\tO\ngum\tO\nArabic\tO\nand\tO\nGM\tO\nsignificantly\tO\nincreased\tO\ncreatinine\tO\nand\tO\nurea\tO\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tT-1\nGM\tB-Chemical\n-\tO\ninduced\tT-2\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tO\ntogether\tO\nwith\tO\ngum\tO\nArabic\tO\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tO\nand\tO\ncellulose\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ngum\tO\nArabic\tO\nand\tO\nGM\tO\nsignificantly\tO\nincreased\tO\ncreatinine\tO\nand\tO\nurea\tO\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tO\nGM\tT-0\n-\tT-0\ninduced\tT-0\nproximal\tT-0\ntubular\tB-Disease\nnecrosis\tI-Disease\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tO\ntogether\tO\nwith\tO\ngum\tO\nArabic\tO\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tO\nand\tO\ncellulose\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ngum\tO\nArabic\tO\nand\tO\nGM\tO\nsignificantly\tO\nincreased\tO\ncreatinine\tO\nand\tO\nurea\tO\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tO\nGM\tO\n-\tO\ninduced\tO\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tT-0\nsevere\tT-0\nin\tT-0\nrats\tT-0\ngiven\tT-0\nGM\tB-Chemical\ntogether\tT-1\nwith\tT-1\ngum\tT-1\nArabic\tT-1\nthan\tO\nin\tO\nthose\tO\ngiven\tO\nGM\tO\nand\tO\ncellulose\tO\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tO\nwith\tO\ngum\tT-0\nArabic\tT-0\nand\tO\nGM\tO\nsignificantly\tO\nincreased\tO\ncreatinine\tT-1\nand\tO\nurea\tT-2\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tO\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tO\nGM\tO\n-\tO\ninduced\tO\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tT-3\ntogether\tT-3\nwith\tT-3\ngum\tB-Chemical\nArabic\tI-Chemical\nthan\tT-4\nin\tT-4\nthose\tT-4\ngiven\tT-4\nGM\tT-4\nand\tT-4\ncellulose\tT-4\n.\tO\n\nThe\tO\nresults\tO\nindicated\tO\nthat\tO\nconcomitant\tO\ntreatment\tT-2\nwith\tO\ngum\tO\nArabic\tO\nand\tO\nGM\tO\nsignificantly\tO\nincreased\tO\ncreatinine\tO\nand\tO\nurea\tO\nby\tO\nabout\tO\n183\tO\nand\tO\n239\tO\n%\tO\n,\tO\nrespectively\tO\n(\tO\ncompared\tT-3\nto\tO\n432\tO\nand\tO\n346\tO\n%\tO\n,\tO\nrespectively\tO\n,\tO\nin\tO\nrats\tO\ntreated\tO\nwith\tO\ncellulose\tO\nand\tO\nGM\tO\n)\tO\n,\tO\nand\tO\ndecreased\tO\nthat\tO\nof\tO\ncortical\tO\nGSH\tO\nby\tO\n21\tO\n%\tO\n(\tO\ncompared\tO\nto\tO\n27\tO\n%\tO\nin\tO\nthe\tO\ncellulose\tO\nplus\tO\nGM\tO\ngroup\tO\n)\tO\nThe\tO\nGM\tO\n-\tO\ninduced\tT-4\nproximal\tO\ntubular\tO\nnecrosis\tO\nappeared\tO\nto\tO\nbe\tO\nslightly\tO\nless\tO\nsevere\tO\nin\tO\nrats\tO\ngiven\tO\nGM\tO\ntogether\tO\nwith\tO\ngum\tO\nArabic\tO\nthan\tO\nin\tO\nthose\tT-1\ngiven\tT-1\nGM\tB-Chemical\nand\tO\ncellulose\tO\n.\tO\n\nIt\tO\ncould\tO\nbe\tO\ninferred\tO\nthat\tO\ngum\tO\nArabic\tO\ntreatment\tO\nhas\tO\ninduced\tT-0\na\tT-0\nmodest\tT-0\namelioration\tT-0\nof\tO\nsome\tO\nof\tO\nthe\tO\nhistological\tO\nand\tO\nbiochemical\tO\nindices\tO\nof\tO\nGM\tB-Chemical\nnephrotoxicity\tO\n.\tO\n\nIt\tO\ncould\tO\nbe\tO\ninferred\tO\nthat\tO\ngum\tO\nArabic\tO\ntreatment\tO\nhas\tO\ninduced\tT-0\na\tT-0\nmodest\tT-0\namelioration\tT-0\nof\tT-0\nsome\tO\nof\tO\nthe\tO\nhistological\tO\nand\tO\nbiochemical\tO\nindices\tT-1\nof\tO\nGM\tO\nnephrotoxicity\tB-Disease\n.\tO\n\nFurther\tO\nwork\tO\nis\tO\nwarranted\tO\non\tO\nthe\tO\neffect\tT-0\nof\tT-0\nthe\tT-0\ntreatments\tT-0\non\tT-0\nrenal\tO\nfunctional\tO\naspects\tO\nin\tO\nmodels\tT-1\nof\tT-1\nchronic\tB-Disease\nrenal\tI-Disease\nfailure\tI-Disease\n,\tO\nand\tO\non\tO\nthe\tO\nmechanism\tT-2\n(\tT-2\ns\tT-2\n)\tT-2\ninvolved\tT-2\n.\tO\n\nIncreased\tT-1\nfrequency\tT-1\nof\tT-1\nvenous\tB-Disease\nthromboembolism\tI-Disease\nwith\tO\nthe\tO\ncombination\tO\nof\tO\ndocetaxel\tO\nand\tO\nthalidomide\tO\nin\tO\npatients\tO\nwith\tO\nmetastatic\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tO\ncancer\tO\n.\tO\n\nIncreased\tO\nfrequency\tO\nof\tO\nvenous\tO\nthromboembolism\tO\nwith\tO\nthe\tO\ncombination\tT-1\nof\tT-1\ndocetaxel\tB-Chemical\nand\tT-0\nthalidomide\tT-0\nin\tO\npatients\tO\nwith\tO\nmetastatic\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tO\ncancer\tO\n.\tO\n\nIncreased\tT-0\nfrequency\tT-0\nof\tT-0\nvenous\tT-0\nthromboembolism\tT-0\nwith\tO\nthe\tO\ncombination\tT-1\nof\tT-1\ndocetaxel\tO\nand\tO\nthalidomide\tB-Chemical\nin\tO\npatients\tO\nwith\tO\nmetastatic\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tO\ncancer\tO\n.\tO\n\nIncreased\tO\nfrequency\tO\nof\tO\nvenous\tO\nthromboembolism\tO\nwith\tO\nthe\tO\ncombination\tO\nof\tO\ndocetaxel\tO\nand\tO\nthalidomide\tO\nin\tO\npatients\tO\nwith\tO\nmetastatic\tO\nandrogen\tO\n-\tO\nindependent\tT-0\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nfrequency\tT-0\nof\tT-0\nvenous\tB-Disease\nthromboembolism\tI-Disease\n(\tT-1\nVTE\tT-1\n)\tT-1\nin\tO\npatients\tO\nwith\tO\nadvanced\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tO\ncancer\tO\nwho\tO\nwere\tO\ntreated\tO\nwith\tO\ndocetaxel\tO\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nthalidomide\tO\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nfrequency\tT-2\nof\tT-2\nvenous\tT-0\nthromboembolism\tT-0\n(\tO\nVTE\tB-Disease\n)\tO\nin\tT-1\npatients\tT-1\nwith\tT-1\nadvanced\tT-1\nandrogen\tT-1\n-\tO\nindependent\tO\nprostate\tO\ncancer\tO\nwho\tO\nwere\tO\ntreated\tO\nwith\tO\ndocetaxel\tO\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nthalidomide\tO\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nfrequency\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tO\n)\tO\nin\tO\npatients\tO\nwith\tO\nadvanced\tO\nandrogen\tO\n-\tO\nindependent\tT-0\nprostate\tB-Disease\ncancer\tI-Disease\nwho\tO\nwere\tO\ntreated\tT-1\nwith\tT-1\ndocetaxel\tO\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nthalidomide\tO\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nfrequency\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tO\n)\tO\nin\tO\npatients\tO\nwith\tO\nadvanced\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tO\ncancer\tO\nwho\tO\nwere\tO\ntreated\tT-0\nwith\tT-0\ndocetaxel\tB-Chemical\nalone\tO\nor\tO\nin\tO\ncombination\tO\nwith\tO\nthalidomide\tO\n.\tO\n\nSTUDY\tO\nOBJECTIVE\tO\n:\tO\nTo\tO\nevaluate\tO\nthe\tO\nfrequency\tO\nof\tO\nvenous\tO\nthromboembolism\tO\n(\tO\nVTE\tO\n)\tO\nin\tO\npatients\tO\nwith\tO\nadvanced\tO\nandrogen\tO\n-\tO\nindependent\tO\nprostate\tO\ncancer\tO\nwho\tO\nwere\tO\ntreated\tT-1\nwith\tO\ndocetaxel\tO\nalone\tO\nor\tO\nin\tT-2\ncombination\tT-2\nwith\tT-2\nthalidomide\tB-Chemical\n.\tO\n\nPATIENTS\tT-0\n:\tO\nSeventy\tO\nmen\tO\n,\tO\naged\tO\n50\tO\n-\tO\n80\tO\nyears\tO\n,\tO\nwith\tT-3\nadvanced\tT-3\nandrogen\tO\n-\tO\nindependent\tT-2\nprostate\tB-Disease\ncancer\tI-Disease\n.\tO\n\nINTERVENTION\tO\n:\tO\nEach\tO\npatient\tO\nreceived\tO\neither\tO\nintravenous\tT-1\ndocetaxel\tB-Chemical\n30\tO\nmg\tT-0\n/\tT-0\nm2\tT-0\n/\tT-0\nweek\tT-0\nfor\tT-0\n3\tT-0\nconsecutive\tT-0\nweeks\tT-0\n,\tO\nfollowed\tO\nby\tO\n1\tO\nweek\tO\noff\tO\n,\tO\nor\tO\nthe\tO\ncombination\tO\nof\tO\ncontinuous\tO\noral\tO\nthalidomide\tO\n200\tO\nmg\tO\nevery\tO\nevening\tO\nplus\tO\nthe\tO\nsame\tO\ndocetaxel\tO\nregimen\tO\n.\tO\n\nINTERVENTION\tO\n:\tO\nEach\tO\npatient\tO\nreceived\tT-0\neither\tT-0\nintravenous\tT-0\ndocetaxel\tO\n30\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nweek\tO\nfor\tO\n3\tO\nconsecutive\tO\nweeks\tO\n,\tO\nfollowed\tO\nby\tO\n1\tO\nweek\tO\noff\tO\n,\tO\nor\tO\nthe\tO\ncombination\tO\nof\tO\ncontinuous\tT-1\noral\tT-1\nthalidomide\tB-Chemical\n200\tO\nmg\tO\nevery\tO\nevening\tO\nplus\tO\nthe\tO\nsame\tO\ndocetaxel\tO\nregimen\tO\n.\tO\n\nINTERVENTION\tO\n:\tO\nEach\tO\npatient\tO\nreceived\tO\neither\tO\nintravenous\tO\ndocetaxel\tO\n30\tO\nmg\tO\n/\tO\nm2\tO\n/\tO\nweek\tO\nfor\tO\n3\tO\nconsecutive\tO\nweeks\tO\n,\tO\nfollowed\tO\nby\tO\n1\tO\nweek\tO\noff\tO\n,\tO\nor\tO\nthe\tO\ncombination\tO\nof\tO\ncontinuous\tO\noral\tO\nthalidomide\tO\n200\tO\nmg\tO\nevery\tO\nevening\tO\nplus\tO\nthe\tT-1\nsame\tT-1\ndocetaxel\tB-Chemical\nregimen\tO\n.\tO\n\nThis\tO\n4\tO\n-\tO\nweek\tO\ncycle\tO\nwas\tO\nrepeated\tO\nuntil\tO\nthere\tO\nwas\tO\nevidence\tO\nof\tO\nexcessive\tT-0\ntoxicity\tB-Disease\nor\tO\ndisease\tT-1\nprogression\tT-1\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nNone\tO\nof\tO\n23\tO\npatients\tT-1\nwho\tO\nreceived\tT-0\ndocetaxel\tB-Chemical\nalone\tO\ndeveloped\tO\nVTE\tO\n,\tO\nwhereas\tO\n9\tO\nof\tO\n47\tO\npatients\tT-2\n(\tO\n19\tO\n%\tO\n)\tO\nwho\tO\nreceived\tO\ndocetaxel\tO\nplus\tO\nthalidomide\tO\ndeveloped\tO\nVTE\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nNone\tO\nof\tO\n23\tT-1\npatients\tT-1\nwho\tO\nreceived\tO\ndocetaxel\tO\nalone\tO\ndeveloped\tT-0\nVTE\tB-Disease\n,\tO\nwhereas\tO\n9\tT-2\nof\tT-2\n47\tT-2\npatients\tT-2\n(\tO\n19\tO\n%\tO\n)\tO\nwho\tO\nreceived\tO\ndocetaxel\tO\nplus\tO\nthalidomide\tO\ndeveloped\tO\nVTE\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nNone\tO\nof\tO\n23\tO\npatients\tT-0\nwho\tT-0\nreceived\tT-0\ndocetaxel\tO\nalone\tO\ndeveloped\tO\nVTE\tO\n,\tO\nwhereas\tO\n9\tO\nof\tO\n47\tO\npatients\tO\n(\tO\n19\tO\n%\tO\n)\tO\nwho\tO\nreceived\tT-1\ndocetaxel\tB-Chemical\nplus\tT-2\nthalidomide\tT-2\ndeveloped\tO\nVTE\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nNone\tO\nof\tO\n23\tO\npatients\tO\nwho\tO\nreceived\tO\ndocetaxel\tO\nalone\tO\ndeveloped\tO\nVTE\tO\n,\tO\nwhereas\tO\n9\tO\nof\tO\n47\tO\npatients\tO\n(\tO\n19\tO\n%\tO\n)\tO\nwho\tO\nreceived\tT-1\ndocetaxel\tO\nplus\tO\nthalidomide\tB-Chemical\ndeveloped\tT-0\nVTE\tT-0\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nMEASUREMENTS\tO\nAND\tO\nMAIN\tO\nRESULTS\tO\n:\tO\nNone\tO\nof\tO\n23\tO\npatients\tO\nwho\tO\nreceived\tO\ndocetaxel\tO\nalone\tO\ndeveloped\tO\nVTE\tO\n,\tO\nwhereas\tO\n9\tO\nof\tO\n47\tO\npatients\tO\n(\tO\n19\tO\n%\tO\n)\tO\nwho\tO\nreceived\tO\ndocetaxel\tO\nplus\tO\nthalidomide\tO\ndeveloped\tT-0\nVTE\tB-Disease\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n025\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\naddition\tT-0\nof\tT-0\nthalidomide\tB-Chemical\nto\tO\ndocetaxel\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nprostate\tO\ncancer\tO\nsignificantly\tO\nincreases\tO\nthe\tO\nfrequency\tO\nof\tO\nVTE\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\naddition\tT-2\nof\tT-2\nthalidomide\tO\nto\tT-0\ndocetaxel\tB-Chemical\nin\tT-1\nthe\tO\ntreatment\tT-3\nof\tT-3\nprostate\tO\ncancer\tO\nsignificantly\tO\nincreases\tO\nthe\tO\nfrequency\tO\nof\tO\nVTE\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\naddition\tO\nof\tO\nthalidomide\tO\nto\tO\ndocetaxel\tO\nin\tO\nthe\tO\ntreatment\tT-0\nof\tT-0\nprostate\tB-Disease\ncancer\tI-Disease\nsignificantly\tT-1\nincreases\tT-1\nthe\tO\nfrequency\tO\nof\tO\nVTE\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nThe\tO\naddition\tO\nof\tO\nthalidomide\tO\nto\tO\ndocetaxel\tO\nin\tO\nthe\tO\ntreatment\tO\nof\tO\nprostate\tO\ncancer\tO\nsignificantly\tO\nincreases\tT-0\nthe\tT-0\nfrequency\tT-0\nof\tT-0\nVTE\tB-Disease\n.\tO\n\nClinicians\tO\nshould\tO\nbe\tO\naware\tO\nof\tO\nthis\tO\npotential\tO\ncomplication\tO\nwhen\tO\nadding\tT-0\nthalidomide\tB-Chemical\nto\tO\nchemotherapeutic\tO\nregimens\tO\n.\tO\n\nTiclopidine\tB-Chemical\n-\tO\ninduced\tT-0\ncholestatic\tO\nhepatitis\tO\n.\tO\n\nTiclopidine\tO\n-\tO\ninduced\tT-0\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\n2\tO\ncases\tT-0\nof\tT-0\nticlopidine\tB-Chemical\n-\tO\ninduced\tT-2\ncholestatic\tO\nhepatitis\tO\n,\tO\ninvestigate\tT-3\nits\tT-3\nmechanism\tT-3\n,\tO\nand\tO\ncompare\tO\nthe\tO\nobserved\tO\nmain\tO\ncharacteristics\tO\nwith\tO\nthose\tO\nof\tO\nthe\tO\npublished\tO\ncases\tO\n.\tO\n\nOBJECTIVE\tO\n:\tO\nTo\tO\nreport\tO\n2\tO\ncases\tT-0\nof\tT-0\nticlopidine\tT-2\n-\tT-2\ninduced\tT-2\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n,\tO\ninvestigate\tO\nits\tO\nmechanism\tO\n,\tO\nand\tO\ncompare\tO\nthe\tO\nobserved\tO\nmain\tO\ncharacteristics\tO\nwith\tO\nthose\tO\nof\tO\nthe\tO\npublished\tO\ncases\tO\n.\tO\n\nCASE\tO\nSUMMARIES\tO\n:\tO\nTwo\tO\npatients\tT-0\ndeveloped\tO\nprolonged\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\nafter\tO\nreceiving\tO\nticlopidine\tO\nfollowing\tO\npercutaneous\tO\ncoronary\tO\nangioplasty\tO\n,\tO\nwith\tO\ncomplete\tO\nremission\tO\nduring\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n.\tO\n\nCASE\tO\nSUMMARIES\tO\n:\tO\nTwo\tO\npatients\tO\ndeveloped\tO\nprolonged\tO\ncholestatic\tO\nhepatitis\tO\nafter\tO\nreceiving\tT-0\nticlopidine\tB-Chemical\nfollowing\tO\npercutaneous\tO\ncoronary\tO\nangioplasty\tO\n,\tO\nwith\tO\ncomplete\tO\nremission\tO\nduring\tO\nthe\tO\nfollow\tO\n-\tO\nup\tO\nperiod\tO\n.\tO\n\nT\tO\n-\tO\ncell\tO\nstimulation\tO\nby\tO\ntherapeutic\tO\nconcentration\tT-0\nof\tT-0\nticlopidine\tB-Chemical\nwas\tO\ndemonstrated\tO\nin\tO\nvitro\tO\nin\tO\nthe\tO\npatients\tO\n,\tO\nbut\tO\nnot\tO\nin\tO\nhealthy\tO\ncontrols\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nCholestatic\tB-Disease\nhepatitis\tI-Disease\nis\tO\na\tO\nrare\tO\ncomplication\tT-0\nof\tO\nthe\tO\nantiplatelet\tO\nagent\tO\nticlopidine\tO\n;\tO\nseveral\tO\ncases\tO\nhave\tO\nbeen\tT-1\nreported\tT-1\nbut\tO\nfew\tO\nin\tO\nthe\tO\nEnglish\tO\nliterature\tO\n.\tO\n\nDISCUSSION\tO\n:\tO\nCholestatic\tO\nhepatitis\tO\nis\tO\na\tO\nrare\tO\ncomplication\tO\nof\tO\nthe\tO\nantiplatelet\tO\nagent\tT-0\nticlopidine\tB-Chemical\n;\tO\nseveral\tO\ncases\tO\nhave\tO\nbeen\tO\nreported\tO\nbut\tO\nfew\tO\nin\tO\nthe\tO\nEnglish\tO\nliterature\tO\n.\tO\n\nOur\tO\npatients\tO\ndeveloped\tO\njaundice\tB-Disease\nfollowing\tT-0\ntreatment\tT-0\nwith\tO\nticlopidine\tO\nand\tO\nshowed\tO\nthe\tO\nclinical\tO\nand\tO\nlaboratory\tO\ncharacteristics\tO\nof\tO\ncholestatic\tO\nhepatitis\tO\n,\tO\nwhich\tO\nresolved\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nOur\tO\npatients\tO\ndeveloped\tO\njaundice\tO\nfollowing\tO\ntreatment\tT-1\nwith\tT-1\nticlopidine\tB-Chemical\nand\tT-2\nshowed\tT-2\nthe\tT-2\nclinical\tT-2\nand\tO\nlaboratory\tO\ncharacteristics\tO\nof\tO\ncholestatic\tO\nhepatitis\tO\n,\tO\nwhich\tO\nresolved\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nOur\tT-0\npatients\tT-0\ndeveloped\tT-0\njaundice\tO\nfollowing\tO\ntreatment\tO\nwith\tO\nticlopidine\tO\nand\tO\nshowed\tO\nthe\tO\nclinical\tO\nand\tO\nlaboratory\tO\ncharacteristics\tO\nof\tO\ncholestatic\tB-Disease\nhepatitis\tI-Disease\n,\tO\nwhich\tO\nresolved\tO\nafter\tO\ndiscontinuation\tO\nof\tO\nthe\tO\ndrug\tO\n.\tO\n\nAn\tO\nobjective\tO\ncausality\tO\nassessment\tO\nrevealed\tO\nthat\tO\nthe\tO\nadverse\tO\ndrug\tO\nevent\tO\nwas\tO\nprobably\tO\nrelated\tT-0\nto\tT-0\nthe\tO\nuse\tT-1\nof\tT-1\nticlopidine\tB-Chemical\n.\tO\n\nThe\tO\nmechanisms\tO\nof\tT-0\nthis\tT-0\nticlopidine\tB-Chemical\n-\tO\ninduced\tT-1\ncholestasis\tO\nare\tO\nunclear\tO\n.\tO\n\nThe\tO\nmechanisms\tO\nof\tO\nthis\tO\nticlopidine\tO\n-\tO\ninduced\tT-1\ncholestasis\tB-Disease\nare\tT-0\nunclear\tT-0\n.\tO\n\nImmune\tT-1\nmechanisms\tT-1\nmay\tO\nbe\tO\ninvolved\tT-0\nin\tO\nthe\tO\ndrug\tO\n'\tO\ns\tO\nhepatotoxicity\tB-Disease\n,\tO\nas\tO\nsuggested\tO\nby\tO\nthe\tO\nT\tO\n-\tO\ncell\tO\nstimulation\tO\nstudy\tO\nreported\tO\nhere\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nCholestatic\tB-Disease\nhepatitis\tI-Disease\nis\tT-2\na\tT-2\nrare\tT-2\nadverse\tT-0\neffect\tO\nof\tO\nticlopidine\tO\nthat\tO\nmay\tT-1\nbe\tT-1\nimmune\tT-1\nmediated\tT-1\n.\tT-0\n\nCONCLUSIONS\tO\n:\tO\nCholestatic\tO\nhepatitis\tO\nis\tO\na\tO\nrare\tO\nadverse\tO\neffect\tT-0\nof\tT-0\nticlopidine\tB-Chemical\nthat\tO\nmay\tO\nbe\tO\nimmune\tO\nmediated\tO\n.\tO\n\nThis\tO\ncomplication\tO\nwill\tO\nbe\tO\nobserved\tO\neven\tO\nless\tO\noften\tO\nin\tO\nthe\tO\nfuture\tO\nas\tO\nticlopidine\tB-Chemical\nis\tT-1\nbeing\tT-1\nreplaced\tT-1\nby\tT-0\nthe\tT-0\nnewer\tT-0\nantiplatelet\tT-0\nagent\tO\nclopidogrel\tO\n.\tO\n\nThis\tO\ncomplication\tO\nwill\tO\nbe\tO\nobserved\tO\neven\tO\nless\tO\noften\tO\nin\tO\nthe\tO\nfuture\tO\nas\tO\nticlopidine\tO\nis\tO\nbeing\tO\nreplaced\tT-1\nby\tT-1\nthe\tO\nnewer\tO\nantiplatelet\tO\nagent\tT-0\nclopidogrel\tB-Chemical\n.\tO\n\nEpithelial\tT-2\nsodium\tB-Chemical\nchannel\tT-0\n(\tT-3\nENaC\tT-3\n)\tT-3\nsubunit\tO\nmRNA\tO\nand\tO\nprotein\tT-1\nexpression\tT-1\nin\tO\nrats\tO\nwith\tO\npuromycin\tO\naminonucleoside\tO\n-\tO\ninduced\tO\nnephrotic\tO\nsyndrome\tO\n.\tO\n\nEpithelial\tT-0\nsodium\tT-0\nchannel\tT-0\n(\tO\nENaC\tO\n)\tO\nsubunit\tO\nmRNA\tO\nand\tO\nprotein\tO\nexpression\tO\nin\tO\nrats\tO\nwith\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n-\tO\ninduced\tT-1\nnephrotic\tO\nsyndrome\tO\n.\tO\n\nEpithelial\tO\nsodium\tO\nchannel\tO\n(\tO\nENaC\tO\n)\tO\nsubunit\tO\nmRNA\tO\nand\tO\nprotein\tO\nexpression\tO\nin\tO\nrats\tO\nwith\tO\npuromycin\tO\naminonucleoside\tO\n-\tO\ninduced\tT-0\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nIn\tT-1\nexperimental\tT-1\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n,\tO\nurinary\tT-2\nsodium\tT-2\nexcretion\tT-2\nis\tO\ndecreased\tO\nduring\tO\nthe\tO\nearly\tO\nphase\tO\nof\tO\nthe\tO\ndisease\tO\n.\tO\n\nThe\tO\nrate\tO\n-\tO\nlimiting\tO\nconstituent\tO\nof\tO\ncollecting\tT-1\nduct\tT-1\nsodium\tB-Chemical\ntransport\tO\nis\tO\nthe\tO\nepithelial\tO\nsodium\tO\nchannel\tO\n(\tO\nENaC\tO\n)\tO\n.\tO\n\nThe\tO\nrate\tO\n-\tO\nlimiting\tO\nconstituent\tO\nof\tO\ncollecting\tO\nduct\tO\nsodium\tO\ntransport\tO\nis\tT-0\nthe\tT-0\nepithelial\tO\nsodium\tB-Chemical\nchannel\tO\n(\tT-1\nENaC\tT-1\n)\tT-1\n.\tO\n\nWe\tO\nexamined\tO\nthe\tO\nabundance\tO\nof\tO\nENaC\tO\nsubunit\tO\nmRNAs\tO\nand\tO\nproteins\tO\nin\tO\npuromycin\tB-Chemical\naminonucleoside\tI-Chemical\n(\tO\nPAN\tO\n)\tO\n-\tO\ninduced\tT-0\nnephrotic\tO\nsyndrome\tO\n.\tO\n\nWe\tO\nexamined\tO\nthe\tO\nabundance\tO\nof\tO\nENaC\tO\nsubunit\tO\nmRNAs\tO\nand\tO\nproteins\tT-0\nin\tT-0\npuromycin\tO\naminonucleoside\tO\n(\tO\nPAN\tB-Chemical\n)\tO\n-\tO\ninduced\tT-1\nnephrotic\tO\nsyndrome\tO\n.\tO\n\nWe\tO\nexamined\tO\nthe\tO\nabundance\tO\nof\tO\nENaC\tO\nsubunit\tO\nmRNAs\tO\nand\tO\nproteins\tO\nin\tO\npuromycin\tO\naminonucleoside\tO\n(\tO\nPAN\tO\n)\tO\n-\tO\ninduced\tT-0\nnephrotic\tB-Disease\nsyndrome\tI-Disease\n.\tO\n\nThe\tO\ntime\tT-1\ncourses\tT-1\nof\tO\nurinary\tO\nsodium\tB-Chemical\nexcretion\tT-2\n,\tO\nplasma\tO\naldosterone\tO\nconcentration\tO\nand\tO\nproteinuria\tO\nwere\tO\nstudied\tO\nin\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tO\nwith\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\neither\tO\nPAN\tO\nor\tO\nvehicle\tO\n.\tO\n\nThe\tO\ntime\tO\ncourses\tO\nof\tO\nurinary\tO\nsodium\tO\nexcretion\tO\n,\tO\nplasma\tT-0\naldosterone\tB-Chemical\nconcentration\tT-1\nand\tO\nproteinuria\tO\nwere\tO\nstudied\tO\nin\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tO\nwith\tO\na\tO\nsingle\tO\ndose\tO\nof\tO\neither\tO\nPAN\tO\nor\tO\nvehicle\tO\n.\tO\n\nThe\tO\ntime\tO\ncourses\tO\nof\tO\nurinary\tO\nsodium\tO\nexcretion\tO\n,\tO\nplasma\tO\naldosterone\tO\nconcentration\tO\nand\tO\nproteinuria\tB-Disease\nwere\tO\nstudied\tO\nin\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tT-0\nwith\tT-0\na\tO\nsingle\tO\ndose\tO\nof\tO\neither\tO\nPAN\tO\nor\tO\nvehicle\tO\n.\tO\n\nThe\tO\ntime\tT-0\ncourses\tT-0\nof\tO\nurinary\tO\nsodium\tO\nexcretion\tO\n,\tO\nplasma\tT-2\naldosterone\tT-2\nconcentration\tO\nand\tO\nproteinuria\tO\nwere\tO\nstudied\tO\nin\tO\nmale\tO\nSprague\tO\n-\tO\nDawley\tO\nrats\tO\ntreated\tT-1\nwith\tT-1\na\tT-1\nsingle\tT-1\ndose\tT-1\nof\tO\neither\tO\nPAN\tB-Chemical\nor\tO\nvehicle\tO\n.\tO\n\nThe\tO\nkinetics\tT-0\nof\tT-0\nurinary\tT-0\nsodium\tB-Chemical\nexcretion\tT-1\nand\tO\nthe\tO\nappearance\tO\nof\tO\nproteinuria\tO\nwere\tO\ncomparable\tO\nwith\tO\nthose\tO\nreported\tO\npreviously\tO\n.\tO\n\nThe\tO\nkinetics\tO\nof\tO\nurinary\tO\nsodium\tO\nexcretion\tO\nand\tO\nthe\tO\nappearance\tO\nof\tO\nproteinuria\tB-Disease\nwere\tT-0\ncomparable\tT-0\nwith\tT-0\nthose\tT-0\nreported\tT-0\npreviously\tT-0\n.\tO\n\nSodium\tB-Chemical\nretention\tT-0\noccurred\tO\non\tO\ndays\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nafter\tO\nPAN\tO\ninjection\tO\n.\tO\n\nSodium\tO\nretention\tO\noccurred\tO\non\tO\ndays\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nafter\tO\nPAN\tB-Chemical\ninjection\tT-0\n.\tO\n\nA\tO\nsignificant\tO\nup\tO\n-\tO\nregulation\tO\nof\tO\nalphaENaC\tO\nand\tO\nbetaENaC\tO\nmRNA\tO\nabundance\tO\non\tO\ndays\tO\n1\tO\nand\tO\n2\tO\npreceded\tT-0\nsodium\tB-Chemical\nretention\tO\non\tO\ndays\tO\n2\tO\nand\tO\n3\tO\n.\tO\n\nConversely\tO\n,\tO\ndown\tO\n-\tO\nregulation\tO\nof\tO\nalphaENaC\tO\n,\tO\nbetaENaC\tO\nand\tO\ngammaENaC\tO\nmRNA\tO\nexpression\tO\non\tO\nday\tO\n3\tO\noccurred\tO\nin\tO\nthe\tO\npresence\tT-1\nof\tT-1\nhigh\tT-1\naldosterone\tB-Chemical\nconcentrations\tT-2\n,\tO\nand\tO\nwas\tO\nfollowed\tO\nby\tO\na\tO\nreturn\tO\nof\tO\nsodium\tO\nexcretion\tO\nto\tO\ncontrol\tO\nvalues\tO\n.\tO\n\nConversely\tO\n,\tO\ndown\tO\n-\tO\nregulation\tO\nof\tO\nalphaENaC\tO\n,\tO\nbetaENaC\tO\nand\tO\ngammaENaC\tO\nmRNA\tO\nexpression\tO\non\tO\nday\tO\n3\tO\noccurred\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\nhigh\tO\naldosterone\tO\nconcentrations\tO\n,\tO\nand\tO\nwas\tO\nfollowed\tO\nby\tO\na\tO\nreturn\tT-1\nof\tT-1\nsodium\tB-Chemical\nexcretion\tT-2\nto\tO\ncontrol\tO\nvalues\tO\n.\tO\n\nThe\tO\namounts\tO\nof\tO\nalphaENaC\tO\n,\tO\nbetaENaC\tO\nand\tO\ngammaENaC\tO\nproteins\tO\nwere\tO\nnot\tO\nincreased\tT-0\nduring\tT-0\nPAN\tB-Chemical\n-\tO\ninduced\tT-2\nsodium\tT-2\nretention\tT-2\n.\tO\n\nThe\tO\namounts\tO\nof\tO\nalphaENaC\tO\n,\tO\nbetaENaC\tO\nand\tO\ngammaENaC\tO\nproteins\tO\nwere\tT-3\nnot\tT-3\nincreased\tT-3\nduring\tT-3\nPAN\tT-3\n-\tO\ninduced\tT-1\nsodium\tB-Chemical\nretention\tT-2\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nENaC\tO\nmRNA\tO\nexpression\tO\n,\tO\nespecially\tO\nalphaENaC\tO\n,\tO\nis\tO\nincreased\tO\nin\tO\nthe\tO\nvery\tO\nearly\tO\nphase\tO\nof\tO\nthe\tO\nexperimental\tO\nmodel\tT-0\nof\tT-0\nPAN\tB-Chemical\n-\tO\ninduced\tT-1\nnephrotic\tO\nsyndrome\tO\nin\tO\nrats\tO\n,\tO\nbut\tO\nappears\tO\nto\tO\nescape\tO\nfrom\tO\nthe\tO\nregulation\tO\nby\tO\naldosterone\tO\nafter\tO\nday\tO\n3\tO\n.\tO\n\nIn\tO\nconclusion\tO\n,\tO\nENaC\tO\nmRNA\tO\nexpression\tO\n,\tO\nespecially\tO\nalphaENaC\tO\n,\tO\nis\tO\nincreased\tO\nin\tO\nthe\tO\nvery\tO\nearly\tO\nphase\tO\nof\tO\nthe\tO\nexperimental\tO\nmodel\tO\nof\tO\nPAN\tO\n-\tO\ninduced\tO\nnephrotic\tO\nsyndrome\tO\nin\tO\nrats\tO\n,\tO\nbut\tO\nappears\tO\nto\tO\nescape\tO\nfrom\tO\nthe\tO\nregulation\tT-1\nby\tT-1\naldosterone\tB-Chemical\nafter\tT-0\nday\tT-0\n3\tT-0\n.\tT-0\n\nSub\tO\n-\tO\nchronic\tO\nlow\tT-0\ndose\tT-0\ngamma\tB-Chemical\n-\tI-Chemical\nvinyl\tI-Chemical\nGABA\tI-Chemical\n(\tO\nvigabatrin\tO\n)\tO\ninhibits\tO\ncocaine\tO\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\ndopamine\tO\n.\tO\n\nSub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\ngamma\tO\n-\tO\nvinyl\tO\nGABA\tO\n(\tO\nvigabatrin\tB-Chemical\n)\tO\ninhibits\tT-0\ncocaine\tO\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\ndopamine\tO\n.\tO\n\nSub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\ngamma\tO\n-\tO\nvinyl\tO\nGABA\tO\n(\tO\nvigabatrin\tO\n)\tO\ninhibits\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tT-0\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\ndopamine\tO\n.\tO\n\nSub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\ngamma\tO\n-\tO\nvinyl\tO\nGABA\tO\n(\tO\nvigabatrin\tO\n)\tO\ninhibits\tO\ncocaine\tO\n-\tO\ninduced\tT-0\nincreases\tT-1\nin\tT-1\nnucleus\tO\naccumbens\tO\ndopamine\tB-Chemical\n.\tO\n\nRATIONALE\tO\n:\tO\ngamma\tB-Chemical\n-\tI-Chemical\nVinyl\tI-Chemical\nGABA\tI-Chemical\n(\tO\nGVG\tO\n)\tO\nirreversibly\tT-0\ninhibits\tT-0\nGABA\tO\n-\tO\ntransaminase\tO\n.\tO\n\nRATIONALE\tO\n:\tO\ngamma\tT-0\n-\tT-0\nVinyl\tT-0\nGABA\tT-0\n(\tO\nGVG\tB-Chemical\n)\tO\nirreversibly\tT-1\ninhibits\tT-1\nGABA\tT-1\n-\tT-1\ntransaminase\tT-1\n.\tO\n\nRATIONALE\tO\n:\tO\ngamma\tT-0\n-\tO\nVinyl\tO\nGABA\tO\n(\tO\nGVG\tO\n)\tO\nirreversibly\tT-2\ninhibits\tT-2\nGABA\tB-Chemical\n-\tO\ntransaminase\tT-1\n.\tT-0\n\nThis\tO\nnon\tO\n-\tO\nreceptor\tO\nmediated\tO\ninhibition\tO\nrequires\tO\nde\tO\nnovo\tO\nsynthesis\tO\nfor\tO\nrestoration\tT-0\nof\tO\nfunctional\tO\nGABA\tB-Chemical\ncatabolism\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nGiven\tO\nits\tO\npreclinical\tO\nsuccess\tO\nfor\tT-0\ntreating\tT-0\nsubstance\tB-Disease\nabuse\tI-Disease\nand\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\nvisual\tO\nfield\tO\ndefects\tO\n(\tO\nVFD\tO\n)\tO\nassociated\tO\nwith\tO\ncumulative\tO\nlifetime\tO\nexposure\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\neffects\tO\nof\tO\nsub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tO\non\tO\ncocaine\tO\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\n(\tO\nNAcc\tO\n)\tO\ndopamine\tO\n(\tO\nDA\tO\n)\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nGiven\tO\nits\tO\npreclinical\tO\nsuccess\tO\nfor\tO\ntreating\tO\nsubstance\tO\nabuse\tO\nand\tO\nthe\tO\nincreased\tT-0\nrisk\tO\nof\tO\nvisual\tB-Disease\nfield\tI-Disease\ndefects\tI-Disease\n(\tO\nVFD\tO\n)\tO\nassociated\tT-1\nwith\tT-1\ncumulative\tO\nlifetime\tO\nexposure\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\neffects\tO\nof\tO\nsub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tO\non\tO\ncocaine\tO\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\n(\tO\nNAcc\tO\n)\tO\ndopamine\tO\n(\tO\nDA\tO\n)\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nGiven\tO\nits\tO\npreclinical\tO\nsuccess\tO\nfor\tO\ntreating\tT-0\nsubstance\tO\nabuse\tO\nand\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\nvisual\tO\nfield\tO\ndefects\tO\n(\tO\nVFD\tB-Disease\n)\tO\nassociated\tO\nwith\tO\ncumulative\tO\nlifetime\tO\nexposure\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\neffects\tO\nof\tO\nsub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tO\non\tO\ncocaine\tO\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\n(\tO\nNAcc\tO\n)\tO\ndopamine\tO\n(\tO\nDA\tO\n)\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nGiven\tO\nits\tO\npreclinical\tO\nsuccess\tO\nfor\tO\ntreating\tO\nsubstance\tO\nabuse\tO\nand\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\nvisual\tO\nfield\tO\ndefects\tO\n(\tO\nVFD\tO\n)\tO\nassociated\tO\nwith\tO\ncumulative\tO\nlifetime\tO\nexposure\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\neffects\tO\nof\tO\nsub\tO\n-\tO\nchronic\tT-2\nlow\tT-2\ndose\tT-2\nGVG\tB-Chemical\non\tT-3\ncocaine\tT-3\n-\tO\ninduced\tT-1\nincreases\tO\nin\tO\nnucleus\tO\naccumbens\tO\n(\tO\nNAcc\tO\n)\tO\ndopamine\tO\n(\tO\nDA\tO\n)\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nGiven\tO\nits\tO\npreclinical\tO\nsuccess\tO\nfor\tO\ntreating\tO\nsubstance\tO\nabuse\tO\nand\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\nvisual\tO\nfield\tO\ndefects\tO\n(\tO\nVFD\tO\n)\tO\nassociated\tO\nwith\tO\ncumulative\tO\nlifetime\tO\nexposure\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\neffects\tO\nof\tO\nsub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tO\non\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tT-1\nincreases\tT-1\nin\tO\nnucleus\tO\naccumbens\tO\n(\tO\nNAcc\tO\n)\tO\ndopamine\tO\n(\tO\nDA\tO\n)\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nGiven\tO\nits\tO\npreclinical\tO\nsuccess\tO\nfor\tO\ntreating\tO\nsubstance\tO\nabuse\tO\nand\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\nvisual\tO\nfield\tO\ndefects\tO\n(\tO\nVFD\tO\n)\tO\nassociated\tO\nwith\tO\ncumulative\tO\nlifetime\tO\nexposure\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\neffects\tO\nof\tO\nsub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tO\non\tO\ncocaine\tO\n-\tO\ninduced\tT-0\nincreases\tT-1\nin\tT-1\nnucleus\tT-1\naccumbens\tT-1\n(\tT-1\nNAcc\tT-1\n)\tT-1\ndopamine\tB-Chemical\n(\tO\nDA\tO\n)\tO\n.\tO\n\nOBJECTIVES\tO\n:\tO\nGiven\tO\nits\tO\npreclinical\tO\nsuccess\tO\nfor\tO\ntreating\tO\nsubstance\tO\nabuse\tO\nand\tO\nthe\tO\nincreased\tO\nrisk\tO\nof\tO\nvisual\tO\nfield\tO\ndefects\tO\n(\tO\nVFD\tO\n)\tO\nassociated\tO\nwith\tO\ncumulative\tO\nlifetime\tO\nexposure\tO\n,\tO\nwe\tO\nexplored\tO\nthe\tO\neffects\tO\nof\tO\nsub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tO\non\tO\ncocaine\tO\n-\tO\ninduced\tT-0\nincreases\tT-1\nin\tT-1\nnucleus\tO\naccumbens\tO\n(\tO\nNAcc\tO\n)\tO\ndopamine\tO\n(\tO\nDA\tB-Chemical\n)\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSub\tO\n-\tO\nchronic\tO\nGVG\tB-Chemical\nexposure\tT-1\ninhibited\tT-1\nthe\tT-1\neffect\tT-1\nof\tO\ncocaine\tO\nfor\tO\n3\tO\ndays\tO\n,\tO\nwhich\tO\nexceeded\tO\nin\tO\nmagnitude\tO\nand\tO\nduration\tO\nthe\tO\nidentical\tO\nacute\tO\ndose\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSub\tO\n-\tO\nchronic\tO\nGVG\tO\nexposure\tO\ninhibited\tT-0\nthe\tO\neffect\tT-1\nof\tT-1\ncocaine\tB-Chemical\nfor\tO\n3\tO\ndays\tO\n,\tO\nwhich\tO\nexceeded\tO\nin\tO\nmagnitude\tO\nand\tO\nduration\tO\nthe\tO\nidentical\tO\nacute\tO\ndose\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSub\tO\n-\tO\nchronic\tO\nlow\tT-0\ndose\tT-0\nGVG\tB-Chemical\npotentiates\tT-3\nand\tO\nextends\tO\nthe\tO\ninhibition\tT-1\nof\tT-1\ncocaine\tO\n-\tO\ninduced\tT-2\nincreases\tT-2\nin\tT-2\ndopamine\tO\n,\tO\neffectively\tO\nreducing\tO\ncumulative\tO\nexposures\tO\nand\tO\nthe\tO\nrisk\tO\nfor\tO\nVFDS\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSub\tO\n-\tO\nchronic\tO\nlow\tO\ndose\tO\nGVG\tO\npotentiates\tO\nand\tO\nextends\tO\nthe\tO\ninhibition\tT-0\nof\tO\ncocaine\tB-Chemical\n-\tO\ninduced\tT-1\nincreases\tT-1\nin\tT-1\ndopamine\tT-1\n,\tO\neffectively\tO\nreducing\tO\ncumulative\tO\nexposures\tO\nand\tO\nthe\tO\nrisk\tO\nfor\tO\nVFDS\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nSub\tO\n-\tO\nchronic\tT-0\nlow\tT-0\ndose\tT-0\nGVG\tO\npotentiates\tO\nand\tO\nextends\tO\nthe\tO\ninhibition\tO\nof\tO\ncocaine\tO\n-\tO\ninduced\tT-1\nincreases\tO\nin\tO\ndopamine\tB-Chemical\n,\tO\neffectively\tO\nreducing\tT-2\ncumulative\tO\nexposures\tO\nand\tO\nthe\tO\nrisk\tO\nfor\tO\nVFDS\tO\n.\tO\n\nMR\tO\nimaging\tO\nwith\tO\nquantitative\tO\ndiffusion\tO\nmapping\tT-0\nof\tT-0\ntacrolimus\tB-Chemical\n-\tO\ninduced\tT-1\nneurotoxicity\tO\nin\tO\norgan\tO\ntransplant\tO\npatients\tO\n.\tO\n\nMR\tO\nimaging\tO\nwith\tO\nquantitative\tO\ndiffusion\tO\nmapping\tO\nof\tO\ntacrolimus\tO\n-\tO\ninduced\tT-0\nneurotoxicity\tB-Disease\nin\tO\norgan\tO\ntransplant\tO\npatients\tO\n.\tO\n\nOur\tO\nobjective\tO\nwas\tO\nto\tO\ninvestigate\tO\nbrain\tO\nMR\tO\nimaging\tO\nfindings\tO\nand\tO\nthe\tO\nutility\tO\nof\tO\ndiffusion\tO\n-\tO\nweighted\tO\n(\tO\nDW\tO\n)\tO\nimaging\tO\nin\tO\norgan\tO\ntransplant\tO\npatients\tO\nwho\tO\ndeveloped\tO\nneurologic\tO\nsymptoms\tO\nduring\tT-0\ntacrolimus\tB-Chemical\ntherapy\tT-1\n.\tO\n\nBrain\tO\nMR\tO\nstudies\tO\n,\tO\nincluding\tO\nDW\tO\nimaging\tO\n,\tO\nwere\tO\nprospectively\tO\nperformed\tO\nin\tO\n14\tO\norgan\tO\ntransplant\tO\npatients\tO\nreceiving\tT-0\ntacrolimus\tB-Chemical\nwho\tT-1\ndeveloped\tT-1\nneurologic\tO\ncomplications\tO\n.\tO\n\nBrain\tO\nMR\tO\nstudies\tO\n,\tO\nincluding\tO\nDW\tO\nimaging\tO\n,\tO\nwere\tO\nprospectively\tO\nperformed\tO\nin\tO\n14\tO\norgan\tO\ntransplant\tO\npatients\tT-1\nreceiving\tO\ntacrolimus\tO\nwho\tO\ndeveloped\tT-0\nneurologic\tB-Disease\ncomplications\tI-Disease\n.\tO\n\nOf\tO\nthe\tO\n14\tO\npatients\tT-0\n,\tO\n5\tO\n(\tO\n35\tO\n.\tO\n7\tO\n%\tO\n)\tO\nhad\tT-1\nwhite\tB-Disease\nmatter\tI-Disease\nabnormalities\tI-Disease\n,\tO\n1\tO\n(\tO\n7\tO\n.\tO\n1\tO\n%\tO\n)\tO\nhad\tO\nputaminal\tO\nhemorrhage\tO\n,\tO\nand\tO\n8\tO\n(\tO\n57\tO\n.\tO\n1\tO\n%\tO\n)\tO\nhad\tO\nnormal\tO\nfindings\tO\non\tO\ninitial\tO\nMR\tO\nimages\tO\n.\tO\n\nOf\tO\nthe\tO\n14\tO\npatients\tO\n,\tO\n5\tO\n(\tO\n35\tO\n.\tO\n7\tO\n%\tO\n)\tO\nhad\tO\nwhite\tO\nmatter\tO\nabnormalities\tO\n,\tO\n1\tO\n(\tO\n7\tO\n.\tO\n1\tO\n%\tO\n)\tO\nhad\tT-0\nputaminal\tB-Disease\nhemorrhage\tI-Disease\n,\tO\nand\tO\n8\tO\n(\tO\n57\tO\n.\tO\n1\tO\n%\tO\n)\tO\nhad\tO\nnormal\tO\nfindings\tO\non\tO\ninitial\tO\nMR\tO\nimages\tO\n.\tO\n\nAmong\tT-0\nthe\tO\n5\tO\npatients\tT-1\nwith\tT-1\nwhite\tB-Disease\nmatter\tI-Disease\nabnormalities\tI-Disease\n,\tO\n4\tO\npatients\tO\n(\tO\n80\tO\n.\tO\n0\tO\n%\tO\n)\tO\nshowed\tO\nhigher\tO\nthan\tO\nnormal\tO\nADC\tO\nvalues\tO\non\tO\ninitial\tO\nMR\tO\nimages\tO\n,\tO\nand\tO\nall\tO\nshowed\tO\ncomplete\tO\nresolution\tO\non\tO\nfollow\tO\n-\tO\nup\tO\nimages\tO\n.\tO\n\nThe\tO\nremaining\tO\n1\tO\npatient\tT-0\n(\tO\n20\tO\n.\tO\n0\tO\n%\tO\n)\tO\nshowed\tO\nlower\tO\nthan\tO\nnormal\tO\nADC\tO\nvalue\tO\nand\tO\nshowed\tO\nincomplete\tO\nresolution\tO\nwith\tT-1\ncortical\tB-Disease\nlaminar\tI-Disease\nnecrosis\tI-Disease\n.\tO\n\nDiffusion\tO\n-\tO\nweighted\tO\nimaging\tO\nmay\tO\nbe\tO\nuseful\tO\nin\tO\npredicting\tO\nthe\tO\noutcomes\tO\nof\tO\nthe\tO\nlesions\tT-0\nof\tT-0\ntacrolimus\tB-Chemical\n-\tO\ninduced\tT-1\nneurotoxicity\tT-1\n.\tO\n\nDiffusion\tO\n-\tO\nweighted\tO\nimaging\tO\nmay\tO\nbe\tO\nuseful\tO\nin\tO\npredicting\tO\nthe\tO\noutcomes\tO\nof\tO\nthe\tO\nlesions\tO\nof\tO\ntacrolimus\tO\n-\tO\ninduced\tT-0\nneurotoxicity\tB-Disease\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntransport\tT-1\nin\tO\nhumans\tO\nwith\tO\ncortisol\tO\n-\tO\ninduced\tO\nhypertension\tO\n.\tO\n\nL\tO\n-\tO\narginine\tO\ntransport\tO\nin\tO\nhumans\tT-0\nwith\tT-0\ncortisol\tB-Chemical\n-\tO\ninduced\tT-1\nhypertension\tO\n.\tO\n\nL\tO\n-\tO\narginine\tO\ntransport\tO\nin\tO\nhumans\tO\nwith\tO\ncortisol\tT-2\n-\tT-2\ninduced\tT-2\nhypertension\tB-Disease\n.\tO\n\nA\tO\ndeficient\tT-0\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n-\tO\nnitric\tO\noxide\tO\nsystem\tO\nis\tO\nimplicated\tT-1\nin\tO\ncortisol\tO\n-\tO\ninduced\tO\nhypertension\tO\n.\tO\n\nA\tO\ndeficient\tT-1\nL\tO\n-\tO\narginine\tT-0\n-\tO\nnitric\tB-Chemical\noxide\tI-Chemical\nsystem\tO\nis\tO\nimplicated\tT-2\nin\tO\ncortisol\tO\n-\tO\ninduced\tO\nhypertension\tO\n.\tO\n\nA\tO\ndeficient\tO\nL\tO\n-\tO\narginine\tO\n-\tO\nnitric\tO\noxide\tO\nsystem\tO\nis\tO\nimplicated\tT-0\nin\tT-0\ncortisol\tB-Chemical\n-\tO\ninduced\tO\nhypertension\tO\n.\tO\n\nA\tO\ndeficient\tO\nL\tO\n-\tO\narginine\tO\n-\tO\nnitric\tO\noxide\tO\nsystem\tO\nis\tO\nimplicated\tO\nin\tO\ncortisol\tO\n-\tO\ninduced\tT-0\nhypertension\tB-Disease\n.\tO\n\nWe\tO\ninvestigate\tO\nwhether\tO\nabnormalities\tO\nin\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nuptake\tT-0\ncontribute\tO\nto\tO\nthis\tO\ndeficiency\tO\n.\tO\n\nHydrocortisone\tB-Chemical\nacetate\tI-Chemical\n(\tO\n50\tO\nmg\tO\n)\tO\nwas\tO\ngiven\tT-0\norally\tT-0\nevery\tO\n6\tO\nhours\tO\nfor\tO\n24\tO\nhours\tO\nafter\tO\na\tO\n5\tO\n-\tO\nday\tO\nfixed\tO\n-\tO\nsalt\tO\ndiet\tO\n(\tO\n150\tO\nmmol\tO\n/\tO\nd\tO\n)\tO\n.\tO\n\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nuptake\tT-0\nwas\tO\nassessed\tO\nin\tO\nmononuclear\tO\ncells\tO\nincubated\tO\nwith\tO\nL\tO\n-\tO\narginine\tO\n(\tO\n1\tO\nto\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\n,\tO\nincorporating\tO\n100\tO\nnmol\tO\n/\tO\nL\tO\n[\tO\n3H\tO\n]\tO\n-\tO\nl\tO\n-\tO\narginine\tO\nfor\tO\na\tO\nperiod\tO\nof\tO\n5\tO\nminutes\tO\nat\tO\n37\tO\ndegrees\tO\nC\tO\n.\tO\n\nL\tO\n-\tO\narginine\tO\nuptake\tO\nwas\tO\nassessed\tT-0\nin\tT-0\nmononuclear\tT-0\ncells\tT-0\nincubated\tT-1\nwith\tT-1\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\n(\tO\n1\tO\nto\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\n,\tO\nincorporating\tO\n100\tO\nnmol\tO\n/\tO\nL\tO\n[\tO\n3H\tO\n]\tO\n-\tO\nl\tO\n-\tO\narginine\tO\nfor\tO\na\tO\nperiod\tO\nof\tO\n5\tO\nminutes\tO\nat\tO\n37\tO\ndegrees\tO\nC\tO\n.\tO\n\nL\tO\n-\tO\narginine\tO\nuptake\tO\nwas\tO\nassessed\tO\nin\tO\nmononuclear\tO\ncells\tO\nincubated\tT-0\nwith\tT-0\nL\tO\n-\tO\narginine\tO\n(\tO\n1\tO\nto\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\n,\tO\nincorporating\tO\n100\tO\nnmol\tO\n/\tO\nL\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nl\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nfor\tO\na\tO\nperiod\tO\nof\tO\n5\tO\nminutes\tO\nat\tO\n37\tO\ndegrees\tO\nC\tO\n.\tO\n\nForearm\tO\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nextraction\tT-0\nwas\tO\ncalculated\tO\nafter\tO\ninfusion\tO\nof\tO\n[\tO\n3H\tO\n]\tO\n-\tO\nL\tO\n-\tO\narginine\tO\ninto\tO\nthe\tO\nbrachial\tO\nartery\tO\nat\tO\na\tO\nrate\tO\nof\tO\n100\tO\nnCi\tO\n/\tO\nmin\tO\nfor\tO\n80\tO\nminutes\tO\n.\tO\n\nForearm\tO\n[\tO\n3H\tO\n]\tO\n-\tO\nL\tO\n-\tO\narginine\tO\nextraction\tO\nwas\tO\ncalculated\tO\nafter\tO\ninfusion\tT-0\nof\tT-0\n[\tB-Chemical\n3H\tI-Chemical\n]\tI-Chemical\n-\tI-Chemical\nL\tI-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ninto\tO\nthe\tO\nbrachial\tO\nartery\tO\nat\tO\na\tO\nrate\tO\nof\tO\n100\tO\nnCi\tO\n/\tO\nmin\tO\nfor\tO\n80\tO\nminutes\tO\n.\tO\n\nDeep\tO\nforearm\tO\nvenous\tO\nsamples\tO\nwere\tO\ncollected\tO\nfor\tO\ndetermination\tT-0\nof\tT-0\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nextraction\tT-1\n.\tO\n\nPlasma\tT-0\ncortisol\tB-Chemical\nconcentrations\tT-1\nwere\tO\nsignificantly\tO\nraised\tO\nduring\tO\nthe\tO\nactive\tO\nphase\tO\n(\tO\n323\tO\n+\tO\n/\tO\n-\tO\n43\tO\nto\tO\n1082\tO\n+\tO\n/\tO\n-\tO\n245\tO\nmmol\tO\n/\tO\nL\tO\n,\tO\nP\tO\n<\tO\n0\tO\n.\tO\n05\tO\n)\tO\n.\tO\n\nNeither\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntransport\tT-0\ninto\tT-0\nmononuclear\tO\ncells\tO\n(\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n26\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n6\tO\nvs\tO\n29\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\npmol\tO\n/\tO\n10\tO\n000\tO\ncells\tO\nper\tO\n5\tO\nminutes\tO\n,\tO\nrespectively\tO\n,\tO\nat\tO\nan\tO\nl\tO\n-\tO\narginine\tO\nconcentration\tO\nof\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nnor\tO\nL\tO\n-\tO\narginine\tO\nextraction\tO\nin\tO\nthe\tO\nforearm\tO\n(\tO\nat\tO\n80\tO\nminutes\tO\n,\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n1\tO\n868\tO\n904\tO\n+\tO\n/\tO\n-\tO\n434\tO\n962\tO\nvs\tO\n2\tO\n013\tO\n910\tO\n+\tO\n/\tO\n-\tO\n770\tO\n619\tO\ndisintegrations\tO\nper\tO\nminute\tO\n)\tO\nwas\tO\naffected\tO\nby\tO\ncortisol\tO\ntreatment\tO\n;\tO\nie\tO\n,\tO\nthat\tO\nL\tO\n-\tO\narginine\tO\nuptake\tO\nis\tO\nnot\tO\naffected\tO\nby\tO\nshort\tO\n-\tO\nterm\tO\ncortisol\tO\ntreatment\tO\n.\tO\n\nNeither\tO\nL\tO\n-\tO\narginine\tO\ntransport\tO\ninto\tO\nmononuclear\tO\ncells\tO\n(\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n26\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n6\tO\nvs\tO\n29\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\npmol\tO\n/\tO\n10\tO\n000\tO\ncells\tO\nper\tO\n5\tO\nminutes\tO\n,\tO\nrespectively\tO\n,\tO\nat\tT-0\nan\tT-0\nl\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nconcentration\tT-1\nof\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nnor\tO\nL\tO\n-\tO\narginine\tO\nextraction\tO\nin\tO\nthe\tO\nforearm\tO\n(\tO\nat\tO\n80\tO\nminutes\tO\n,\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n1\tO\n868\tO\n904\tO\n+\tO\n/\tO\n-\tO\n434\tO\n962\tO\nvs\tO\n2\tO\n013\tO\n910\tO\n+\tO\n/\tO\n-\tO\n770\tO\n619\tO\ndisintegrations\tO\nper\tO\nminute\tO\n)\tO\nwas\tO\naffected\tO\nby\tO\ncortisol\tO\ntreatment\tO\n;\tO\nie\tO\n,\tO\nthat\tO\nL\tO\n-\tO\narginine\tO\nuptake\tO\nis\tO\nnot\tO\naffected\tO\nby\tO\nshort\tO\n-\tO\nterm\tO\ncortisol\tO\ntreatment\tO\n.\tO\n\nNeither\tO\nL\tO\n-\tO\narginine\tO\ntransport\tO\ninto\tO\nmononuclear\tO\ncells\tO\n(\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n26\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n6\tO\nvs\tO\n29\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\npmol\tO\n/\tO\n10\tO\n000\tO\ncells\tO\nper\tO\n5\tO\nminutes\tO\n,\tO\nrespectively\tO\n,\tO\nat\tO\nan\tO\nl\tO\n-\tO\narginine\tO\nconcentration\tT-0\nof\tT-0\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nnor\tO\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nextraction\tT-1\nin\tO\nthe\tO\nforearm\tO\n(\tO\nat\tO\n80\tO\nminutes\tO\n,\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n1\tO\n868\tO\n904\tO\n+\tO\n/\tO\n-\tO\n434\tO\n962\tO\nvs\tO\n2\tO\n013\tO\n910\tO\n+\tO\n/\tO\n-\tO\n770\tO\n619\tO\ndisintegrations\tO\nper\tO\nminute\tO\n)\tO\nwas\tO\naffected\tO\nby\tO\ncortisol\tO\ntreatment\tO\n;\tO\nie\tO\n,\tO\nthat\tO\nL\tO\n-\tO\narginine\tO\nuptake\tO\nis\tO\nnot\tO\naffected\tO\nby\tO\nshort\tO\n-\tO\nterm\tO\ncortisol\tO\ntreatment\tO\n.\tO\n\nNeither\tO\nL\tO\n-\tO\narginine\tO\ntransport\tO\ninto\tO\nmononuclear\tO\ncells\tO\n(\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n26\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n6\tO\nvs\tO\n29\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\npmol\tO\n/\tO\n10\tO\n000\tO\ncells\tO\nper\tO\n5\tO\nminutes\tO\n,\tO\nrespectively\tO\n,\tO\nat\tO\nan\tO\nl\tT-0\n-\tT-0\narginine\tT-0\nconcentration\tT-0\nof\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nnor\tO\nL\tO\n-\tO\narginine\tO\nextraction\tO\nin\tO\nthe\tO\nforearm\tO\n(\tO\nat\tO\n80\tO\nminutes\tO\n,\tO\nplacebo\tT-1\nvs\tT-1\nactive\tT-1\n,\tO\n1\tO\n868\tO\n904\tO\n+\tO\n/\tO\n-\tO\n434\tO\n962\tO\nvs\tO\n2\tO\n013\tO\n910\tO\n+\tO\n/\tO\n-\tO\n770\tO\n619\tO\ndisintegrations\tO\nper\tO\nminute\tO\n)\tO\nwas\tO\naffected\tO\nby\tO\ncortisol\tB-Chemical\ntreatment\tO\n;\tO\nie\tO\n,\tO\nthat\tO\nL\tO\n-\tO\narginine\tO\nuptake\tO\nis\tO\nnot\tO\naffected\tO\nby\tO\nshort\tO\n-\tO\nterm\tO\ncortisol\tO\ntreatment\tO\n.\tO\n\nNeither\tO\nL\tO\n-\tO\narginine\tO\ntransport\tO\ninto\tO\nmononuclear\tO\ncells\tO\n(\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n26\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n6\tO\nvs\tO\n29\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\npmol\tO\n/\tO\n10\tO\n000\tO\ncells\tO\nper\tO\n5\tO\nminutes\tO\n,\tO\nrespectively\tO\n,\tO\nat\tO\nan\tO\nl\tO\n-\tO\narginine\tO\nconcentration\tO\nof\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nnor\tO\nL\tO\n-\tO\narginine\tO\nextraction\tO\nin\tO\nthe\tO\nforearm\tO\n(\tO\nat\tO\n80\tO\nminutes\tO\n,\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n1\tO\n868\tO\n904\tO\n+\tO\n/\tO\n-\tO\n434\tO\n962\tO\nvs\tO\n2\tO\n013\tO\n910\tO\n+\tO\n/\tO\n-\tO\n770\tO\n619\tO\ndisintegrations\tO\nper\tO\nminute\tO\n)\tO\nwas\tO\naffected\tO\nby\tO\ncortisol\tO\ntreatment\tO\n;\tO\nie\tO\n,\tO\nthat\tT-0\nL\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\nuptake\tT-1\nis\tO\nnot\tO\naffected\tO\nby\tO\nshort\tO\n-\tO\nterm\tO\ncortisol\tO\ntreatment\tO\n.\tO\n\nNeither\tO\nL\tT-0\n-\tT-0\narginine\tT-0\ntransport\tT-0\ninto\tO\nmononuclear\tO\ncells\tO\n(\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n26\tO\n.\tO\n3\tO\n+\tO\n/\tO\n-\tO\n3\tO\n.\tO\n6\tO\nvs\tO\n29\tO\n.\tO\n0\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n1\tO\npmol\tO\n/\tO\n10\tO\n000\tO\ncells\tO\nper\tO\n5\tO\nminutes\tO\n,\tO\nrespectively\tO\n,\tO\nat\tO\nan\tO\nl\tO\n-\tO\narginine\tO\nconcentration\tO\nof\tO\n300\tO\nmicromol\tO\n/\tO\nL\tO\n)\tO\nnor\tO\nL\tO\n-\tO\narginine\tO\nextraction\tO\nin\tO\nthe\tO\nforearm\tO\n(\tO\nat\tO\n80\tO\nminutes\tO\n,\tO\nplacebo\tO\nvs\tO\nactive\tO\n,\tO\n1\tO\n868\tO\n904\tO\n+\tO\n/\tO\n-\tO\n434\tO\n962\tO\nvs\tO\n2\tO\n013\tO\n910\tO\n+\tO\n/\tO\n-\tO\n770\tO\n619\tO\ndisintegrations\tO\nper\tO\nminute\tO\n)\tO\nwas\tO\naffected\tO\nby\tO\ncortisol\tO\ntreatment\tO\n;\tO\nie\tO\n,\tO\nthat\tO\nL\tO\n-\tO\narginine\tO\nuptake\tO\nis\tO\nnot\tT-1\naffected\tT-1\nby\tT-1\nshort\tT-1\n-\tT-1\nterm\tT-1\ncortisol\tB-Chemical\ntreatment\tT-2\n.\tO\n\nWe\tO\nconclude\tT-0\nthat\tT-0\ncortisol\tB-Chemical\n-\tO\ninduced\tT-1\nincreases\tO\nin\tO\nblood\tO\npressure\tO\nare\tO\nnot\tO\nassociated\tO\nwith\tO\nabnormalities\tO\nin\tO\nthe\tO\nl\tO\n-\tO\narginine\tO\ntransport\tO\nsystem\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\ncortisol\tO\n-\tO\ninduced\tT-0\nincreases\tB-Disease\nin\tI-Disease\nblood\tI-Disease\npressure\tI-Disease\nare\tT-1\nnot\tT-1\nassociated\tT-1\nwith\tO\nabnormalities\tO\nin\tO\nthe\tO\nl\tO\n-\tO\narginine\tO\ntransport\tO\nsystem\tO\n.\tO\n\nWe\tO\nconclude\tO\nthat\tO\ncortisol\tO\n-\tO\ninduced\tO\nincreases\tO\nin\tO\nblood\tO\npressure\tO\nare\tO\nnot\tO\nassociated\tO\nwith\tO\nabnormalities\tT-0\nin\tT-0\nthe\tT-0\nl\tB-Chemical\n-\tI-Chemical\narginine\tI-Chemical\ntransport\tT-1\nsystem\tT-1\n.\tO\n\nAmount\tO\nof\tO\nbleeding\tB-Disease\nand\tO\nhematoma\tO\nsize\tO\nin\tO\nthe\tO\ncollagenase\tO\n-\tO\ninduced\tT-0\nintracerebral\tO\nhemorrhage\tO\nrat\tO\nmodel\tO\n.\tO\n\nAmount\tO\nof\tO\nbleeding\tO\nand\tO\nhematoma\tB-Disease\nsize\tO\nin\tO\nthe\tO\ncollagenase\tO\n-\tO\ninduced\tT-0\nintracerebral\tO\nhemorrhage\tO\nrat\tO\nmodel\tO\n.\tO\n\nAmount\tO\nof\tO\nbleeding\tO\nand\tO\nhematoma\tO\nsize\tO\nin\tO\nthe\tO\ncollagenase\tO\n-\tO\ninduced\tT-0\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\nrat\tT-1\nmodel\tT-1\n.\tO\n\nThe\tO\naggravated\tT-3\nrisk\tT-3\non\tT-3\nintracerebral\tB-Disease\nhemorrhage\tI-Disease\n(\tO\nICH\tO\n)\tO\nwith\tO\ndrugs\tT-1\nused\tO\nfor\tO\nstroke\tO\npatients\tT-2\nshould\tO\nbe\tO\nestimated\tO\ncarefully\tO\n.\tO\n\nThe\tO\naggravated\tO\nrisk\tO\non\tO\nintracerebral\tT-1\nhemorrhage\tT-1\n(\tO\nICH\tB-Disease\n)\tO\nwith\tO\ndrugs\tO\nused\tO\nfor\tO\nstroke\tT-0\npatients\tT-0\nshould\tO\nbe\tO\nestimated\tO\ncarefully\tO\n.\tO\n\nThe\tO\naggravated\tO\nrisk\tO\non\tO\nintracerebral\tO\nhemorrhage\tO\n(\tO\nICH\tO\n)\tO\nwith\tO\ndrugs\tT-0\nused\tT-0\nfor\tT-0\nstroke\tB-Disease\npatients\tO\nshould\tO\nbe\tO\nestimated\tO\ncarefully\tO\n.\tO\n\nWe\tO\ntherefore\tO\nestablished\tO\nsensitive\tO\nquantification\tO\nmethods\tO\nand\tO\nprovided\tT-1\na\tT-1\nrat\tT-1\nICH\tB-Disease\nmodel\tT-2\nfor\tT-2\ndetection\tT-2\nof\tT-2\nICH\tT-2\ndeterioration\tT-2\n.\tO\n\nWe\tO\ntherefore\tO\nestablished\tO\nsensitive\tO\nquantification\tO\nmethods\tO\nand\tO\nprovided\tO\na\tO\nrat\tO\nICH\tO\nmodel\tO\nfor\tO\ndetection\tT-0\nof\tT-0\nICH\tB-Disease\ndeterioration\tT-1\n.\tO\n\nIn\tO\nICH\tB-Disease\nintrastriatally\tO\ninduced\tT-0\nby\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\n,\tO\n0\tO\n.\tO\n070\tO\n-\tO\nunit\tO\n,\tO\nand\tO\n0\tO\n.\tO\n350\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nthe\tO\namount\tO\nof\tO\nbleeding\tO\nwas\tO\nmeasured\tO\nusing\tO\na\tO\nhemoglobin\tO\nassay\tO\ndeveloped\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\nand\tO\nwas\tO\ncompared\tO\nwith\tO\nthe\tO\nmorphologically\tO\ndetermined\tO\nhematoma\tO\nvolume\tO\n.\tO\n\nIn\tO\nICH\tO\nintrastriatally\tO\ninduced\tO\nby\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\n,\tO\n0\tO\n.\tO\n070\tO\n-\tO\nunit\tO\n,\tO\nand\tO\n0\tO\n.\tO\n350\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nthe\tT-0\namount\tT-0\nof\tT-0\nbleeding\tB-Disease\nwas\tT-1\nmeasured\tT-1\nusing\tO\na\tO\nhemoglobin\tO\nassay\tO\ndeveloped\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\nand\tO\nwas\tO\ncompared\tO\nwith\tO\nthe\tO\nmorphologically\tO\ndetermined\tO\nhematoma\tO\nvolume\tO\n.\tO\n\nIn\tO\nICH\tO\nintrastriatally\tO\ninduced\tO\nby\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\n,\tO\n0\tO\n.\tO\n070\tO\n-\tO\nunit\tO\n,\tO\nand\tO\n0\tO\n.\tO\n350\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nthe\tO\namount\tO\nof\tO\nbleeding\tO\nwas\tO\nmeasured\tO\nusing\tO\na\tO\nhemoglobin\tO\nassay\tO\ndeveloped\tO\nin\tO\nthe\tO\npresent\tO\nstudy\tO\nand\tO\nwas\tO\ncompared\tO\nwith\tO\nthe\tO\nmorphologically\tO\ndetermined\tT-0\nhematoma\tB-Disease\nvolume\tT-1\n.\tO\n\nThe\tO\nblood\tT-0\namounts\tT-0\nand\tO\nhematoma\tB-Disease\nvolumes\tT-1\nwere\tO\nsignificantly\tO\ncorrelated\tO\n,\tO\nand\tO\nthe\tO\nhematoma\tO\ninduced\tO\nby\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\nwas\tO\nadequate\tO\nto\tO\ndetect\tO\nICH\tO\ndeterioration\tO\n.\tO\n\nThe\tO\nblood\tO\namounts\tO\nand\tO\nhematoma\tO\nvolumes\tO\nwere\tO\nsignificantly\tO\ncorrelated\tO\n,\tO\nand\tO\nthe\tO\nhematoma\tB-Disease\ninduced\tT-0\nby\tT-0\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\nwas\tO\nadequate\tO\nto\tO\ndetect\tO\nICH\tO\ndeterioration\tO\n.\tO\n\nThe\tO\nblood\tO\namounts\tO\nand\tO\nhematoma\tO\nvolumes\tO\nwere\tO\nsignificantly\tO\ncorrelated\tO\n,\tO\nand\tO\nthe\tO\nhematoma\tO\ninduced\tO\nby\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\nwas\tO\nadequate\tO\nto\tO\ndetect\tT-0\nICH\tB-Disease\ndeterioration\tT-1\n.\tO\n\nIn\tO\nICH\tB-Disease\ninduction\tT-0\nusing\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nheparin\tO\nenhanced\tO\nthe\tO\nhematoma\tO\nvolume\tO\n3\tO\n.\tO\n4\tO\n-\tO\nfold\tO\nover\tO\nthat\tO\nseen\tO\nin\tO\ncontrol\tO\nICH\tO\nanimals\tO\nand\tO\nthe\tO\nbleeding\tO\n7\tO\n.\tO\n6\tO\n-\tO\nfold\tO\n.\tO\n\nIn\tO\nICH\tO\ninduction\tT-0\nusing\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nheparin\tB-Chemical\nenhanced\tT-1\nthe\tO\nhematoma\tO\nvolume\tO\n3\tO\n.\tO\n4\tO\n-\tO\nfold\tO\nover\tO\nthat\tO\nseen\tO\nin\tO\ncontrol\tO\nICH\tO\nanimals\tO\nand\tO\nthe\tO\nbleeding\tO\n7\tO\n.\tO\n6\tO\n-\tO\nfold\tO\n.\tO\n\nIn\tO\nICH\tO\ninduction\tO\nusing\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nheparin\tO\nenhanced\tT-0\nthe\tO\nhematoma\tB-Disease\nvolume\tT-1\n3\tO\n.\tO\n4\tO\n-\tO\nfold\tO\nover\tO\nthat\tO\nseen\tO\nin\tO\ncontrol\tO\nICH\tO\nanimals\tO\nand\tO\nthe\tO\nbleeding\tO\n7\tO\n.\tO\n6\tO\n-\tO\nfold\tO\n.\tO\n\nIn\tO\nICH\tO\ninduction\tO\nusing\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nheparin\tO\nenhanced\tO\nthe\tO\nhematoma\tO\nvolume\tO\n3\tO\n.\tO\n4\tO\n-\tO\nfold\tO\nover\tO\nthat\tO\nseen\tO\nin\tT-0\ncontrol\tT-0\nICH\tB-Disease\nanimals\tT-1\nand\tO\nthe\tO\nbleeding\tO\n7\tO\n.\tO\n6\tO\n-\tO\nfold\tO\n.\tO\n\nIn\tO\nICH\tO\ninduction\tO\nusing\tO\n0\tO\n.\tO\n014\tO\n-\tO\nunit\tO\ncollagenase\tO\n,\tO\nheparin\tT-0\nenhanced\tT-0\nthe\tT-0\nhematoma\tT-0\nvolume\tT-0\n3\tO\n.\tO\n4\tO\n-\tO\nfold\tO\nover\tO\nthat\tO\nseen\tO\nin\tO\ncontrol\tO\nICH\tO\nanimals\tO\nand\tT-1\nthe\tT-1\nbleeding\tB-Disease\n7\tO\n.\tO\n6\tO\n-\tO\nfold\tO\n.\tO\n\nData\tO\nsuggest\tO\nthat\tO\nthis\tO\nsensitive\tO\nhemoglobin\tO\nassay\tO\nis\tT-1\nuseful\tT-1\nfor\tT-1\nICH\tB-Disease\ndetection\tT-2\n,\tO\nand\tO\nthat\tO\na\tO\nmodel\tO\nwith\tO\na\tO\nsmall\tO\nICH\tO\ninduced\tO\nwith\tO\na\tO\nlow\tO\n-\tO\ndose\tO\ncollagenase\tO\nshould\tO\nbe\tO\nused\tO\nfor\tO\nevaluation\tO\nof\tO\ndrugs\tO\nthat\tO\nmay\tO\naffect\tO\nICH\tO\n.\tO\n\nData\tO\nsuggest\tO\nthat\tO\nthis\tO\nsensitive\tO\nhemoglobin\tO\nassay\tO\nis\tO\nuseful\tO\nfor\tO\nICH\tO\ndetection\tO\n,\tO\nand\tO\nthat\tO\na\tO\nmodel\tO\nwith\tT-0\na\tT-0\nsmall\tT-0\nICH\tB-Disease\ninduced\tT-1\nwith\tT-1\na\tT-1\nlow\tT-1\n-\tO\ndose\tO\ncollagenase\tO\nshould\tO\nbe\tO\nused\tO\nfor\tO\nevaluation\tO\nof\tO\ndrugs\tO\nthat\tO\nmay\tO\naffect\tO\nICH\tO\n.\tO\n\nData\tO\nsuggest\tO\nthat\tO\nthis\tO\nsensitive\tO\nhemoglobin\tO\nassay\tO\nis\tO\nuseful\tO\nfor\tO\nICH\tO\ndetection\tO\n,\tO\nand\tO\nthat\tO\na\tO\nmodel\tO\nwith\tO\na\tO\nsmall\tO\nICH\tO\ninduced\tO\nwith\tO\na\tO\nlow\tO\n-\tO\ndose\tO\ncollagenase\tO\nshould\tO\nbe\tO\nused\tO\nfor\tO\nevaluation\tO\nof\tO\ndrugs\tO\nthat\tO\nmay\tT-0\naffect\tT-0\nICH\tB-Disease\n.\tO\n\nEstradiol\tB-Chemical\nreduces\tT-1\nseizure\tT-1\n-\tO\ninduced\tO\nhippocampal\tO\ninjury\tO\nin\tO\novariectomized\tO\nfemale\tO\nbut\tO\nnot\tO\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nEstradiol\tO\nreduces\tT-0\nseizure\tB-Disease\n-\tO\ninduced\tT-1\nhippocampal\tO\ninjury\tO\nin\tO\novariectomized\tO\nfemale\tO\nbut\tO\nnot\tO\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nEstradiol\tO\nreduces\tO\nseizure\tO\n-\tO\ninduced\tT-1\nhippocampal\tB-Disease\ninjury\tI-Disease\nin\tT-0\novariectomized\tT-0\nfemale\tO\nbut\tO\nnot\tO\nin\tO\nmale\tO\nrats\tO\n.\tO\n\nEstrogens\tT-1\nprotect\tT-1\novariectomized\tO\nrats\tO\nfrom\tO\nhippocampal\tB-Disease\ninjury\tI-Disease\ninduced\tT-2\nby\tT-2\nkainic\tT-2\nacid\tT-2\n-\tO\ninduced\tO\nstatus\tO\nepilepticus\tO\n(\tO\nSE\tO\n)\tO\n.\tO\n\nEstrogens\tO\nprotect\tO\novariectomized\tO\nrats\tO\nfrom\tO\nhippocampal\tO\ninjury\tO\ninduced\tT-0\nby\tT-0\nkainic\tB-Chemical\nacid\tI-Chemical\n-\tO\ninduced\tO\nstatus\tO\nepilepticus\tO\n(\tO\nSE\tO\n)\tO\n.\tO\n\nEstrogens\tO\nprotect\tO\novariectomized\tO\nrats\tO\nfrom\tO\nhippocampal\tO\ninjury\tO\ninduced\tO\nby\tO\nkainic\tO\nacid\tO\n-\tO\ninduced\tT-0\nstatus\tB-Disease\nepilepticus\tI-Disease\n(\tO\nSE\tO\n)\tO\n.\tO\n\nEstrogens\tO\nprotect\tO\novariectomized\tO\nrats\tO\nfrom\tO\nhippocampal\tO\ninjury\tO\ninduced\tO\nby\tO\nkainic\tO\nacid\tO\n-\tO\ninduced\tT-0\nstatus\tT-0\nepilepticus\tT-0\n(\tO\nSE\tB-Disease\n)\tO\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\neffects\tT-0\nof\tT-0\n17beta\tB-Chemical\n-\tI-Chemical\nestradiol\tI-Chemical\nin\tT-1\nadult\tT-1\nmale\tT-1\nand\tO\novariectomized\tO\nfemale\tO\nrats\tO\nsubjected\tO\nto\tO\nlithium\tO\n-\tO\npilocarpine\tO\n-\tO\ninduced\tO\nSE\tO\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\neffects\tO\nof\tO\n17beta\tO\n-\tO\nestradiol\tO\nin\tO\nadult\tO\nmale\tO\nand\tO\novariectomized\tO\nfemale\tO\nrats\tO\nsubjected\tT-0\nto\tT-0\nlithium\tB-Chemical\n-\tO\npilocarpine\tO\n-\tO\ninduced\tO\nSE\tO\n.\tO\n\nWe\tO\ncompared\tT-1\nthe\tT-1\neffects\tT-1\nof\tT-1\n17beta\tO\n-\tO\nestradiol\tO\nin\tO\nadult\tO\nmale\tO\nand\tO\novariectomized\tO\nfemale\tO\nrats\tO\nsubjected\tT-2\nto\tT-2\nlithium\tO\n-\tO\npilocarpine\tB-Chemical\n-\tO\ninduced\tT-0\nSE\tT-0\n.\tO\n\nWe\tO\ncompared\tO\nthe\tO\neffects\tT-0\nof\tT-0\n17beta\tO\n-\tO\nestradiol\tO\nin\tO\nadult\tO\nmale\tO\nand\tO\novariectomized\tO\nfemale\tO\nrats\tO\nsubjected\tT-1\nto\tT-1\nlithium\tO\n-\tO\npilocarpine\tO\n-\tO\ninduced\tT-2\nSE\tB-Disease\n.\tO\n\nRats\tO\nreceived\tO\nsubcutaneous\tO\ninjections\tT-0\nof\tT-0\n17beta\tB-Chemical\n-\tI-Chemical\nestradiol\tI-Chemical\n(\tO\n2\tO\nmicrog\tO\n/\tO\nrat\tO\n)\tO\nor\tO\noil\tO\nonce\tO\ndaily\tO\nfor\tO\nfour\tO\nconsecutive\tO\ndays\tO\n.\tO\n\nSE\tB-Disease\nwas\tT-1\ninduced\tT-1\n20\tO\nh\tO\nfollowing\tO\nthe\tO\nsecond\tO\ninjection\tO\nand\tO\nterminated\tO\n3\tO\nh\tO\nlater\tO\n.\tO\n\nThe\tO\nextent\tT-0\nof\tO\nsilver\tB-Chemical\n-\tO\nstained\tT-1\nCA3\tO\nand\tO\nCA1\tO\nhippocampal\tO\nneurons\tO\nwas\tO\nevaluated\tO\n2\tO\ndays\tO\nafter\tO\nSE\tO\n.\tO\n\nThe\tO\nextent\tO\nof\tO\nsilver\tO\n-\tO\nstained\tO\nCA3\tO\nand\tO\nCA1\tO\nhippocampal\tO\nneurons\tO\nwas\tT-1\nevaluated\tT-1\n2\tT-1\ndays\tT-1\nafter\tT-1\nSE\tB-Disease\n.\tO\n\n17beta\tB-Chemical\n-\tI-Chemical\nEstradiol\tI-Chemical\ndid\tT-0\nnot\tT-0\nalter\tT-0\nthe\tO\nonset\tO\nof\tO\nfirst\tO\nclonus\tO\nin\tO\novariectomized\tO\nrats\tO\nbut\tO\naccelerated\tO\nit\tO\nin\tO\nmales\tO\n.\tO\n\n17beta\tB-Chemical\n-\tI-Chemical\nEstradiol\tI-Chemical\nreduced\tT-1\nthe\tO\nargyrophilic\tT-0\nneurons\tT-0\nin\tO\nthe\tO\nCA1\tO\nand\tO\nCA3\tO\n-\tO\nC\tO\nsectors\tO\nof\tO\novariectomized\tO\nrats\tO\n.\tO\n\nIn\tO\nmales\tO\n,\tO\nestradiol\tB-Chemical\nincreased\tO\nthe\tO\ntotal\tT-0\ndamage\tT-0\nscore\tT-0\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nthe\tO\neffects\tT-0\nof\tT-0\nestradiol\tB-Chemical\non\tO\nseizure\tO\nthreshold\tO\nand\tO\ndamage\tO\nmay\tO\nbe\tO\naltered\tO\nby\tO\nsex\tO\n-\tO\nrelated\tO\ndifferences\tO\nin\tO\nthe\tO\nhormonal\tO\nenvironment\tO\n.\tO\n\nThese\tO\nfindings\tO\nsuggest\tO\nthat\tO\nthe\tO\neffects\tO\nof\tO\nestradiol\tT-0\non\tT-0\nseizure\tB-Disease\nthreshold\tT-1\nand\tT-1\ndamage\tT-1\nmay\tO\nbe\tO\naltered\tO\nby\tO\nsex\tO\n-\tO\nrelated\tO\ndifferences\tO\nin\tO\nthe\tO\nhormonal\tO\nenvironment\tO\n.\tO\n\nPseudoacromegaly\tB-Disease\ninduced\tT-0\nby\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nminoxidil\tO\n.\tO\n\nPseudoacromegaly\tT-0\ninduced\tT-2\nby\tT-2\nthe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tT-1\nof\tT-1\nminoxidil\tB-Chemical\n.\tO\n\nAcromegaly\tB-Disease\nis\tO\nan\tO\nendocrine\tO\ndisorder\tT-0\ncaused\tT-0\nby\tT-0\nchronic\tO\nexcessive\tO\ngrowth\tO\nhormone\tO\nsecretion\tO\nfrom\tO\nthe\tO\nanterior\tO\npituitary\tO\ngland\tO\n.\tO\n\nAcromegaly\tO\nis\tT-1\nan\tT-1\nendocrine\tB-Disease\ndisorder\tI-Disease\ncaused\tT-2\nby\tT-2\nchronic\tT-2\nexcessive\tT-2\ngrowth\tO\nhormone\tO\nsecretion\tO\nfrom\tO\nthe\tO\nanterior\tO\npituitary\tO\ngland\tO\n.\tO\n\nSignificant\tO\ndisfiguring\tO\nchanges\tO\noccur\tT-1\nas\tT-0\na\tT-0\nresult\tT-0\nof\tT-0\nbone\tO\n,\tO\ncartilage\tO\n,\tO\nand\tO\nsoft\tO\ntissue\tO\nhypertrophy\tO\n,\tO\nincluding\tO\nthe\tO\nthickening\tO\nof\tO\nthe\tO\nskin\tO\n,\tO\ncoarsening\tO\nof\tO\nfacial\tO\nfeatures\tO\n,\tO\nand\tO\ncutis\tB-Disease\nverticis\tI-Disease\ngyrata\tI-Disease\n.\tO\n\nPseudoacromegaly\tB-Disease\n,\tO\non\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\nis\tO\nthe\tO\npresence\tT-0\nof\tT-0\nsimilar\tT-0\nacromegaloid\tT-0\nfeatures\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nelevated\tO\ngrowth\tO\nhormone\tO\nor\tO\ninsulin\tO\n-\tO\nlike\tO\ngrowth\tO\nfactor\tO\nlevels\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\npatient\tT-1\nwith\tT-1\npseudoacromegaly\tB-Disease\nthat\tO\nresulted\tO\nfrom\tO\nthe\tO\nlong\tO\n-\tO\nterm\tO\nuse\tO\nof\tO\nminoxidil\tO\nat\tO\nan\tO\nunusually\tO\nhigh\tO\ndose\tO\n.\tO\n\nWe\tO\npresent\tO\na\tO\npatient\tT-0\nwith\tO\npseudoacromegaly\tO\nthat\tO\nresulted\tO\nfrom\tO\nthe\tO\nlong\tT-3\n-\tT-3\nterm\tT-3\nuse\tT-3\nof\tT-3\nminoxidil\tB-Chemical\nat\tO\nan\tO\nunusually\tO\nhigh\tT-2\ndose\tT-2\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tT-0\ncase\tT-0\nreport\tT-0\nof\tO\npseudoacromegaly\tB-Disease\nas\tO\na\tO\nside\tT-1\neffect\tT-1\nof\tT-1\nminoxidil\tO\nuse\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\ncase\tO\nreport\tO\nof\tO\npseudoacromegaly\tO\nas\tO\na\tO\nside\tT-1\neffect\tT-1\nof\tT-1\nminoxidil\tB-Chemical\nuse\tT-0\n.\tO\n\nCombined\tO\nandrogen\tT-1\nblockade\tT-1\n-\tT-1\ninduced\tT-1\nanemia\tB-Disease\nin\tO\nprostate\tO\ncancer\tO\npatients\tO\nwithout\tO\nbone\tO\ninvolvement\tO\n.\tO\n\nCombined\tT-1\nandrogen\tT-1\nblockade\tT-1\n-\tT-1\ninduced\tT-1\nanemia\tT-1\nin\tO\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tT-2\nwithout\tT-2\nbone\tT-2\ninvolvement\tT-2\n.\tT-2\n\nBACKGROUND\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nonset\tO\nand\tO\nextent\tO\nof\tO\ncombined\tO\nandrogen\tO\nblockade\tO\n(\tO\nCAB\tO\n)\tO\n-\tO\ninduced\tT-0\nanemia\tB-Disease\nin\tT-1\nprostate\tT-1\ncancer\tT-1\npatients\tT-1\nwithout\tO\nbone\tO\ninvolvement\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nTo\tO\ndetermine\tO\nthe\tO\nonset\tO\nand\tO\nextent\tO\nof\tO\ncombined\tO\nandrogen\tO\nblockade\tO\n(\tO\nCAB\tO\n)\tO\n-\tO\ninduced\tT-1\nanemia\tT-0\nin\tT-0\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tO\nwithout\tO\nbone\tO\ninvolvement\tO\n.\tO\n\nPATIENTS\tO\nAND\tO\nMETHODS\tO\n:\tO\nForty\tT-1\n-\tT-1\ntwo\tT-1\npatients\tT-1\nwith\tT-1\nbiopsy\tT-1\n-\tT-1\nproven\tT-1\nprostatic\tB-Disease\nadenocarcinoma\tI-Disease\n[\tO\n26\tO\nwith\tO\nstage\tO\nC\tO\n(\tO\nT3N0M0\tO\n)\tO\nand\tO\n16\tO\nwith\tO\nstage\tO\nD1\tO\n(\tO\nT3N1M0\tO\n)\tO\n]\tO\nwere\tO\nincluded\tO\nin\tO\nthis\tO\nstudy\tO\n.\tO\n\nAll\tO\npatients\tO\nreceived\tT-0\nCAB\tT-1\n[\tO\nleuprolide\tB-Chemical\nacetate\tI-Chemical\n(\tO\nLHRH\tO\n-\tO\nA\tO\n)\tO\n3\tO\n.\tO\n75\tO\nmg\tO\n,\tO\nintramuscularly\tO\n,\tO\nevery\tO\n28\tO\ndays\tO\nplus\tO\n250\tO\nmg\tO\nflutamide\tO\n,\tO\ntid\tO\n,\tO\nper\tO\nOs\tO\n]\tO\nand\tO\nwere\tO\nevaluated\tO\nfor\tO\nanemia\tO\nby\tO\nphysical\tO\nexamination\tO\nand\tO\nlaboratory\tO\ntests\tO\nat\tO\nbaseline\tO\nand\tO\n4\tO\nsubsequent\tO\nintervals\tO\n(\tO\n1\tO\n,\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n)\tO\n.\tO\n\nAll\tO\npatients\tT-0\nreceived\tT-0\nCAB\tO\n[\tO\nleuprolide\tO\nacetate\tO\n(\tO\nLHRH\tB-Chemical\n-\tI-Chemical\nA\tI-Chemical\n)\tO\n3\tO\n.\tO\n75\tO\nmg\tO\n,\tO\nintramuscularly\tO\n,\tO\nevery\tO\n28\tO\ndays\tO\nplus\tO\n250\tO\nmg\tO\nflutamide\tO\n,\tO\ntid\tO\n,\tO\nper\tO\nOs\tO\n]\tO\nand\tO\nwere\tO\nevaluated\tO\nfor\tO\nanemia\tO\nby\tO\nphysical\tO\nexamination\tO\nand\tO\nlaboratory\tO\ntests\tO\nat\tO\nbaseline\tO\nand\tO\n4\tO\nsubsequent\tO\nintervals\tO\n(\tO\n1\tO\n,\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n)\tO\n.\tO\n\nAll\tO\npatients\tT-0\nreceived\tT-0\nCAB\tO\n[\tO\nleuprolide\tO\nacetate\tO\n(\tO\nLHRH\tO\n-\tO\nA\tO\n)\tO\n3\tO\n.\tO\n75\tO\nmg\tO\n,\tO\nintramuscularly\tO\n,\tO\nevery\tO\n28\tO\ndays\tO\nplus\tO\n250\tO\nmg\tO\nflutamide\tB-Chemical\n,\tO\ntid\tT-1\n,\tO\nper\tO\nOs\tO\n]\tO\nand\tO\nwere\tO\nevaluated\tO\nfor\tO\nanemia\tO\nby\tO\nphysical\tO\nexamination\tO\nand\tO\nlaboratory\tO\ntests\tO\nat\tO\nbaseline\tO\nand\tO\n4\tO\nsubsequent\tO\nintervals\tO\n(\tO\n1\tO\n,\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n)\tO\n.\tO\n\nAll\tO\npatients\tO\nreceived\tO\nCAB\tO\n[\tO\nleuprolide\tO\nacetate\tO\n(\tO\nLHRH\tO\n-\tO\nA\tO\n)\tO\n3\tO\n.\tO\n75\tO\nmg\tO\n,\tO\nintramuscularly\tO\n,\tO\nevery\tO\n28\tO\ndays\tO\nplus\tO\n250\tO\nmg\tO\nflutamide\tO\n,\tO\ntid\tO\n,\tO\nper\tO\nOs\tO\n]\tO\nand\tO\nwere\tO\nevaluated\tT-0\nfor\tT-0\nanemia\tB-Disease\nby\tT-1\nphysical\tT-1\nexamination\tT-1\nand\tO\nlaboratory\tO\ntests\tO\nat\tO\nbaseline\tO\nand\tO\n4\tO\nsubsequent\tO\nintervals\tO\n(\tO\n1\tO\n,\tO\n2\tO\n,\tO\n3\tO\nand\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n)\tO\n.\tO\n\nHb\tO\n,\tO\nPSA\tO\nand\tO\nTestosterone\tB-Chemical\nmeasurements\tT-0\nwere\tO\nrecorded\tT-1\n.\tO\n\nSevere\tO\nand\tO\nclinically\tO\nevident\tT-0\nanemia\tB-Disease\nof\tO\nHb\tO\n<\tO\n11\tO\ng\tO\n/\tO\ndl\tO\nwith\tO\nclinical\tO\nsymptoms\tO\nwas\tO\ndetected\tO\nin\tO\n6\tO\npatients\tO\n(\tO\n14\tO\n.\tO\n3\tO\n%\tO\n)\tO\n.\tO\n\nThis\tO\nCAB\tT-3\n-\tT-3\ninduced\tT-3\nanemia\tB-Disease\nwas\tO\nnormochromic\tT-1\nand\tO\nnormocytic\tT-2\n.\tO\n\nAt\tO\nsix\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n,\tO\npatients\tO\nwith\tO\nsevere\tT-0\nanemia\tB-Disease\nhad\tT-1\na\tT-1\nHb\tO\nmean\tO\nvalue\tO\nof\tO\n10\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\ng\tO\n/\tO\ndl\tO\n(\tO\nX\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n,\tO\nwhereas\tO\nthe\tO\nother\tO\npatients\tO\nhad\tO\nmild\tO\nanemia\tO\nwith\tO\nHb\tO\nmean\tO\nvalue\tO\nof\tO\n13\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n17\tO\n(\tO\nX\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n.\tO\n\nAt\tO\nsix\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\n,\tO\npatients\tT-0\nwith\tO\nsevere\tO\nanemia\tO\nhad\tO\na\tO\nHb\tO\nmean\tO\nvalue\tO\nof\tO\n10\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n1\tO\ng\tO\n/\tO\ndl\tO\n(\tO\nX\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n,\tO\nwhereas\tO\nthe\tO\nother\tO\npatients\tT-2\nhad\tT-2\nmild\tO\nanemia\tB-Disease\nwith\tO\nHb\tO\nmean\tO\nvalue\tO\nof\tO\n13\tO\n.\tO\n2\tO\n+\tO\n/\tO\n-\tO\n0\tO\n.\tO\n17\tO\n(\tO\nX\tO\n+\tO\n/\tO\n-\tO\nSE\tO\n)\tO\n.\tO\n\nThe\tT-2\ndevelopment\tT-2\nof\tT-2\nsevere\tT-2\nanemia\tB-Disease\nat\tO\n6\tO\nmonths\tO\npost\tO\n-\tO\nCAB\tO\nwas\tO\npredictable\tO\nby\tO\nthe\tO\nreduction\tT-0\nof\tO\nHb\tO\nbaseline\tO\nvalue\tO\nof\tO\nmore\tO\nthan\tO\n2\tO\n.\tO\n5\tO\ng\tO\n/\tO\ndl\tO\nafter\tO\n3\tO\nmonths\tO\nof\tO\nCAB\tO\n(\tO\np\tO\n=\tO\n0\tO\n.\tO\n01\tO\n)\tO\n.\tO\n\nThe\tO\ndevelopment\tT-2\nof\tT-2\nsevere\tT-2\nCAB\tO\n-\tO\ninduced\tT-0\nanemia\tB-Disease\nin\tT-1\nprostate\tT-1\ncancer\tT-1\npatients\tT-1\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nT\tO\nbaseline\tO\nvalues\tO\n(\tO\nT\tO\n<\tO\n3\tO\nng\tO\n/\tO\nml\tO\nversus\tO\nT\tO\n>\tO\nor\tO\n=\tO\n3\tO\nng\tO\n/\tO\nml\tO\n)\tO\n,\tO\nwith\tO\nage\tO\n(\tO\n<\tO\n76\tO\nyrs\tO\nversus\tO\n>\tO\nor\tO\n=\tO\n76\tO\nyrs\tO\n)\tO\n,\tO\nand\tO\nclinical\tO\nstage\tO\n(\tO\nstage\tO\nC\tO\nversus\tO\nstage\tO\nD1\tO\n)\tO\n.\tO\n\nThe\tO\ndevelopment\tO\nof\tO\nsevere\tO\nCAB\tO\n-\tO\ninduced\tO\nanemia\tT-1\nin\tT-1\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tT-0\ndid\tO\nnot\tO\ncorrelate\tO\nwith\tO\nT\tO\nbaseline\tO\nvalues\tO\n(\tO\nT\tO\n<\tO\n3\tO\nng\tO\n/\tO\nml\tO\nversus\tO\nT\tO\n>\tO\nor\tO\n=\tO\n3\tO\nng\tO\n/\tO\nml\tO\n)\tO\n,\tO\nwith\tO\nage\tO\n(\tO\n<\tO\n76\tO\nyrs\tO\nversus\tO\n>\tO\nor\tO\n=\tO\n76\tO\nyrs\tO\n)\tO\n,\tO\nand\tO\nclinical\tO\nstage\tO\n(\tO\nstage\tO\nC\tO\nversus\tO\nstage\tO\nD1\tO\n)\tO\n.\tO\n\nSevere\tO\nand\tO\nclinically\tT-1\nevident\tT-1\nanemia\tB-Disease\nwas\tO\neasily\tO\ncorrected\tO\nby\tO\nsubcutaneous\tT-0\ninjections\tT-0\n(\tO\n3\tO\ntimes\tO\n/\tO\nweek\tO\nfor\tO\n1\tO\nmonth\tO\n)\tO\nof\tO\nrecombinant\tO\nerythropoietin\tO\n(\tO\nrHuEPO\tO\n-\tO\nbeta\tO\n)\tO\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\ndata\tO\nsuggest\tO\nthat\tO\nrHuEPO\tO\n-\tO\nbeta\tO\ncorrectable\tO\nCAB\tO\n-\tO\ninduced\tT-2\nanemia\tB-Disease\noccurs\tT-0\nin\tT-0\n14\tT-0\n.\tT-0\n3\tT-0\n%\tT-0\nof\tT-0\nprostate\tO\ncancer\tO\npatients\tT-1\nafter\tT-1\n6\tT-1\nmonths\tT-1\nof\tO\ntherapy\tT-3\n.\tO\n\nCONCLUSION\tO\n:\tO\nOur\tO\ndata\tO\nsuggest\tO\nthat\tO\nrHuEPO\tO\n-\tO\nbeta\tO\ncorrectable\tO\nCAB\tO\n-\tO\ninduced\tT-2\nanemia\tO\noccurs\tT-0\nin\tT-0\n14\tT-3\n.\tT-3\n3\tT-3\n%\tT-3\nof\tT-3\nprostate\tB-Disease\ncancer\tI-Disease\npatients\tT-4\nafter\tO\n6\tO\nmonths\tO\nof\tO\ntherapy\tO\n.\tO\n\nDelirium\tB-Disease\nduring\tT-0\nclozapine\tO\ntreatment\tO\n:\tO\nincidence\tO\nand\tO\nassociated\tO\nrisk\tO\nfactors\tO\n.\tO\n\nDelirium\tO\nduring\tT-1\nclozapine\tB-Chemical\ntreatment\tT-2\n:\tO\nincidence\tO\nand\tO\nassociated\tO\nrisk\tT-0\nfactors\tT-0\n.\tO\n\nBACKGROUND\tO\n:\tO\nIncidence\tO\nand\tO\nrisk\tT-2\nfactors\tT-2\nfor\tT-2\ndelirium\tB-Disease\nduring\tT-3\nclozapine\tT-3\ntreatment\tO\nrequire\tO\nfurther\tO\nclarification\tO\n.\tO\n\nBACKGROUND\tO\n:\tO\nIncidence\tO\nand\tO\nrisk\tO\nfactors\tO\nfor\tO\ndelirium\tT-0\nduring\tT-0\nclozapine\tB-Chemical\ntreatment\tT-1\nrequire\tO\nfurther\tO\nclarification\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nused\tO\ncomputerized\tT-0\npharmacy\tT-0\nrecords\tT-0\nto\tO\nidentify\tT-2\nall\tO\nadult\tO\npsychiatric\tB-Disease\ninpatients\tO\ntreated\tT-3\nwith\tO\nclozapine\tO\n(\tO\n1995\tO\n-\tO\n96\tO\n)\tO\n,\tO\nreviewed\tO\ntheir\tO\nmedical\tO\nrecords\tO\nto\tO\nscore\tO\nincidence\tT-4\nand\tT-4\nseverity\tT-4\nof\tO\ndelirium\tO\n,\tO\nand\tO\ntested\tO\nassociations\tO\nwith\tO\npotential\tT-1\nrisk\tT-1\nfactors\tT-1\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nused\tO\ncomputerized\tO\npharmacy\tO\nrecords\tO\nto\tO\nidentify\tO\nall\tO\nadult\tO\npsychiatric\tO\ninpatients\tO\ntreated\tT-0\nwith\tT-0\nclozapine\tB-Chemical\n(\tO\n1995\tO\n-\tO\n96\tO\n)\tO\n,\tO\nreviewed\tO\ntheir\tO\nmedical\tO\nrecords\tO\nto\tO\nscore\tO\nincidence\tO\nand\tO\nseverity\tO\nof\tO\ndelirium\tO\n,\tO\nand\tO\ntested\tO\nassociations\tO\nwith\tO\npotential\tO\nrisk\tO\nfactors\tO\n.\tO\n\nMETHODS\tO\n:\tO\nWe\tO\nused\tO\ncomputerized\tO\npharmacy\tO\nrecords\tO\nto\tO\nidentify\tO\nall\tO\nadult\tO\npsychiatric\tO\ninpatients\tO\ntreated\tO\nwith\tO\nclozapine\tO\n(\tO\n1995\tO\n-\tO\n96\tO\n)\tO\n,\tO\nreviewed\tO\ntheir\tO\nmedical\tO\nrecords\tO\nto\tO\nscore\tO\nincidence\tT-0\nand\tO\nseverity\tT-1\nof\tO\ndelirium\tB-Disease\n,\tO\nand\tO\ntested\tT-2\nassociations\tO\nwith\tO\npotential\tO\nrisk\tO\nfactors\tO\n.\tO\n\nRESULTS\tO\n:\tO\nSubjects\tO\n(\tO\nn\tO\n=\tO\n139\tO\n)\tO\nwere\tO\n72\tO\nwomen\tO\nand\tO\n67\tO\nmen\tO\n,\tO\naged\tO\n40\tO\n.\tO\n8\tO\n+\tO\n/\tO\n-\tO\n12\tO\n.\tO\n1\tO\nyears\tO\n,\tO\nhospitalized\tO\nfor\tO\n24\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n23\tO\n.\tO\n3\tO\ndays\tO\n,\tO\nand\tO\ngiven\tO\nclozapine\tB-Chemical\n,\tO\ngradually\tT-1\nincreased\tT-1\nto\tO\nan\tO\naverage\tO\ndaily\tT-0\ndose\tT-0\nof\tT-0\n282\tO\n+\tO\n/\tO\n-\tO\n203\tO\nmg\tO\n(\tO\n3\tO\n.\tO\n45\tO\n+\tO\n/\tO\n-\tO\n2\tO\n.\tO\n45\tO\nmg\tO\n/\tO\nkg\tO\n)\tO\nfor\tO\n18\tO\n.\tO\n9\tO\n+\tO\n/\tO\n-\tO\n16\tO\n.\tO\n4\tO\ndays\tO\n.\tO\n\nDelirium\tB-Disease\nwas\tO\ndiagnosed\tT-0\nin\tT-0\n14\tO\n(\tO\n10\tO\n.\tO\n1\tO\n%\tO\nincidence\tO\n,\tO\nor\tO\n1\tO\n.\tO\n48\tO\ncases\tO\n/\tO\nperson\tO\n-\tO\nyears\tO\nof\tO\nexposure\tO\n)\tO\n;\tO\n71\tO\n.\tO\n4\tO\n%\tO\nof\tO\ncases\tO\nwere\tO\nmoderate\tO\nor\tO\nsevere\tO\n.\tO\n\nAssociated\tO\nfactors\tO\nwere\tO\nco\tO\n-\tO\ntreatment\tO\nwith\tO\nother\tO\ncentrally\tO\nantimuscarinic\tO\nagents\tO\n,\tO\npoor\tO\nclinical\tO\noutcome\tO\n,\tO\nolder\tO\nage\tO\n,\tO\nand\tO\nlonger\tO\nhospitalization\tO\n(\tO\nby\tO\n17\tO\n.\tO\n5\tO\ndays\tO\n,\tO\nincreasing\tO\ncost\tO\n)\tO\n;\tO\nsex\tO\n,\tO\ndiagnosis\tO\nor\tO\nmedical\tO\nco\tO\n-\tO\nmorbidity\tO\n,\tO\nand\tT-0\ndaily\tT-0\nclozapine\tB-Chemical\ndose\tO\n,\tO\nwhich\tO\nfell\tO\nwith\tO\nage\tO\n,\tO\nwere\tO\nunrelated\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDelirium\tB-Disease\nwas\tT-1\nfound\tT-1\nin\tO\n10\tO\n%\tO\nof\tO\nclozapine\tT-0\n-\tT-0\ntreated\tT-0\ninpatients\tT-0\n,\tO\nparticularly\tO\nin\tO\nolder\tO\npatients\tO\nexposed\tO\nto\tO\nother\tO\ncentral\tO\nanticholinergics\tO\n.\tO\n\nCONCLUSIONS\tO\n:\tO\nDelirium\tO\nwas\tO\nfound\tO\nin\tO\n10\tO\n%\tO\nof\tO\nclozapine\tB-Chemical\n-\tO\ntreated\tT-0\ninpatients\tT-0\n,\tO\nparticularly\tO\nin\tO\nolder\tO\npatients\tT-1\nexposed\tT-1\nto\tO\nother\tO\ncentral\tO\nanticholinergics\tO\n.\tO\n\nDelirium\tB-Disease\nwas\tO\ninconsistently\tO\nrecognized\tT-0\nclinically\tT-0\nin\tO\nmilder\tO\ncases\tO\nand\tO\nwas\tO\nassociated\tO\nwith\tO\nincreased\tO\nlength\tO\n-\tO\nof\tO\n-\tO\nstay\tO\nand\tO\nhigher\tO\ncosts\tO\n,\tO\nand\tO\ninferior\tO\nclinical\tO\noutcome\tO\n.\tO\n\nNeuroprotective\tO\naction\tT-3\nof\tT-3\nMPEP\tB-Chemical\n,\tO\na\tO\nselective\tT-1\nmGluR5\tO\nantagonist\tO\n,\tO\nin\tO\nmethamphetamine\tO\n-\tO\ninduced\tT-2\ndopaminergic\tO\nneurotoxicity\tO\nis\tO\nassociated\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\ndopamine\tO\noutflow\tO\nand\tO\ninhibition\tO\nof\tO\nhyperthermia\tO\nin\tO\nrats\tO\n.\tO\n\nNeuroprotective\tT-0\naction\tT-0\nof\tO\nMPEP\tO\n,\tO\na\tO\nselective\tO\nmGluR5\tO\nantagonist\tO\n,\tO\nin\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\ndopaminergic\tO\nneurotoxicity\tO\nis\tO\nassociated\tO\nwith\tO\na\tO\ndecrease\tT-1\nin\tT-1\ndopamine\tT-1\noutflow\tT-1\nand\tO\ninhibition\tO\nof\tO\nhyperthermia\tO\nin\tO\nrats\tO\n.\tO\n\nNeuroprotective\tO\naction\tO\nof\tO\nMPEP\tO\n,\tO\na\tO\nselective\tO\nmGluR5\tO\nantagonist\tO\n,\tO\nin\tO\nmethamphetamine\tO\n-\tO\ninduced\tT-0\ndopaminergic\tO\nneurotoxicity\tB-Disease\nis\tT-1\nassociated\tT-1\nwith\tO\na\tO\ndecrease\tO\nin\tO\ndopamine\tO\noutflow\tO\nand\tO\ninhibition\tO\nof\tO\nhyperthermia\tO\nin\tO\nrats\tO\n.\tO\n\nNeuroprotective\tO\naction\tO\nof\tO\nMPEP\tO\n,\tO\na\tO\nselective\tO\nmGluR5\tO\nantagonist\tO\n,\tO\nin\tO\nmethamphetamine\tO\n-\tO\ninduced\tO\ndopaminergic\tO\nneurotoxicity\tO\nis\tO\nassociated\tO\nwith\tO\na\tO\ndecrease\tT-0\nin\tT-0\ndopamine\tB-Chemical\noutflow\tO\nand\tO\ninhibition\tO\nof\tO\nhyperthermia\tO\nin\tO\nrats\tO\n.\tO\n\nNeuroprotective\tO\naction\tO\nof\tO\nMPEP\tO\n,\tO\na\tO\nselective\tO\nmGluR5\tO\nantagonist\tO\n,\tO\nin\tO\nmethamphetamine\tO\n-\tO\ninduced\tO\ndopaminergic\tO\nneurotoxicity\tO\nis\tO\nassociated\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\ndopamine\tO\noutflow\tO\nand\tO\ninhibition\tT-1\nof\tT-1\nhyperthermia\tB-Disease\nin\tT-2\nrats\tT-2\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\nrole\tT-0\nof\tT-0\nmetabotropic\tT-0\nglutamate\tB-Chemical\nreceptor\tT-0\n5\tO\n(\tO\nmGluR5\tO\n)\tO\nin\tO\nthe\tO\ntoxic\tO\naction\tO\nof\tO\nmethamphetamine\tO\non\tO\ndopaminergic\tO\nneurones\tO\nin\tO\nrats\tO\n.\tO\n\nThe\tO\naim\tO\nof\tO\nthis\tO\nstudy\tO\nwas\tO\nto\tO\nexamine\tO\nthe\tO\nrole\tO\nof\tO\nmetabotropic\tO\nglutamate\tO\nreceptor\tO\n5\tO\n(\tO\nmGluR5\tO\n)\tO\nin\tO\nthe\tO\ntoxic\tT-1\naction\tT-1\nof\tT-1\nmethamphetamine\tB-Chemical\non\tT-0\ndopaminergic\tT-0\nneurones\tT-0\nin\tO\nrats\tO\n.\tO\n\nMethamphetamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\n,\tO\nadministered\tT-0\nfive\tO\ntimes\tO\n,\tO\nreduced\tT-1\nthe\tO\nlevels\tO\nof\tO\ndopamine\tO\nand\tO\nits\tO\nmetabolites\tO\nin\tO\nstriatal\tO\ntissue\tO\nwhen\tO\nmeasured\tO\n72\tO\nh\tO\nafter\tO\nthe\tO\nlast\tO\ninjection\tO\n.\tO\n\nMethamphetamine\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\n,\tO\nadministered\tO\nfive\tO\ntimes\tO\n,\tO\nreduced\tO\nthe\tO\nlevels\tT-1\nof\tT-1\ndopamine\tB-Chemical\nand\tT-0\nits\tT-0\nmetabolites\tT-0\nin\tO\nstriatal\tO\ntissue\tO\nwhen\tO\nmeasured\tO\n72\tO\nh\tO\nafter\tO\nthe\tO\nlast\tO\ninjection\tO\n.\tO\n\nA\tO\nselective\tT-0\nantagonist\tT-3\nof\tT-3\nmGluR5\tT-1\n,\tO\n2\tB-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\n6\tI-Chemical\n-\tI-Chemical\n(\tI-Chemical\nphenylethynyl\tI-Chemical\n)\tI-Chemical\npyridine\tI-Chemical\n(\tO\nMPEP\tT-2\n;\tT-2\n5\tT-2\nmg\tT-2\n/\tT-2\nkg\tT-2\nip\tT-2\n)\tO\n,\tO\nwhen\tO\nadministered\tO\nfive\tO\ntimes\tO\nimmediately\tO\nbefore\tO\neach\tO\nmethamphetamine\tO\ninjection\tO\nreversed\tO\nthe\tO\nabove\tO\n-\tO\nmentioned\tO\nmethamphetamine\tO\neffects\tO\n.\tO\n\nA\tO\nselective\tO\nantagonist\tT-2\nof\tT-2\nmGluR5\tO\n,\tO\n2\tO\n-\tO\nmethyl\tO\n-\tO\n6\tO\n-\tO\n(\tO\nphenylethynyl\tO\n)\tO\npyridine\tT-0\n(\tO\nMPEP\tB-Chemical\n;\tO\n5\tT-1\nmg\tT-1\n/\tT-1\nkg\tT-1\nip\tT-1\n)\tO\n,\tO\nwhen\tO\nadministered\tO\nfive\tO\ntimes\tO\nimmediately\tO\nbefore\tO\neach\tO\nmethamphetamine\tO\ninjection\tO\nreversed\tO\nthe\tO\nabove\tO\n-\tO\nmentioned\tO\nmethamphetamine\tO\neffects\tO\n.\tO\n\nA\tO\nselective\tO\nantagonist\tO\nof\tO\nmGluR5\tO\n,\tO\n2\tO\n-\tO\nmethyl\tO\n-\tO\n6\tO\n-\tO\n(\tO\nphenylethynyl\tO\n)\tO\npyridine\tO\n(\tO\nMPEP\tO\n;\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\n,\tO\nwhen\tO\nadministered\tO\nfive\tO\ntimes\tO\nimmediately\tO\nbefore\tT-0\neach\tT-0\nmethamphetamine\tB-Chemical\ninjection\tO\nreversed\tO\nthe\tO\nabove\tO\n-\tO\nmentioned\tO\nmethamphetamine\tO\neffects\tO\n.\tO\n\nA\tO\nselective\tO\nantagonist\tO\nof\tO\nmGluR5\tO\n,\tO\n2\tO\n-\tO\nmethyl\tO\n-\tO\n6\tO\n-\tO\n(\tO\nphenylethynyl\tO\n)\tO\npyridine\tO\n(\tO\nMPEP\tO\n;\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\n,\tO\nwhen\tO\nadministered\tT-0\nfive\tO\ntimes\tO\nimmediately\tO\nbefore\tO\neach\tO\nmethamphetamine\tO\ninjection\tO\nreversed\tO\nthe\tO\nabove\tO\n-\tO\nmentioned\tO\nmethamphetamine\tB-Chemical\neffects\tT-1\n.\tO\n\nA\tO\nsingle\tT-0\nMPEP\tB-Chemical\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\ninjection\tO\nreduced\tT-1\nthe\tO\nbasal\tO\nextracellular\tO\ndopamine\tO\nlevel\tO\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nas\tO\nwell\tO\nas\tO\ndopamine\tO\nrelease\tO\nstimulated\tO\neither\tO\nby\tO\nmethamphetamine\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\nor\tO\nby\tO\nintrastriatally\tT-2\nadministered\tT-2\nveratridine\tT-2\n(\tO\n100\tO\nmicroM\tO\n)\tO\n.\tO\n\nA\tO\nsingle\tO\nMPEP\tO\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\ninjection\tO\nreduced\tO\nthe\tO\nbasal\tO\nextracellular\tT-0\ndopamine\tB-Chemical\nlevel\tT-1\nin\tT-1\nthe\tT-1\nstriatum\tT-1\n,\tO\nas\tO\nwell\tO\nas\tO\ndopamine\tO\nrelease\tO\nstimulated\tO\neither\tO\nby\tO\nmethamphetamine\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\nor\tO\nby\tO\nintrastriatally\tO\nadministered\tO\nveratridine\tO\n(\tO\n100\tO\nmicroM\tO\n)\tO\n.\tO\n\nA\tO\nsingle\tO\nMPEP\tO\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\ninjection\tO\nreduced\tO\nthe\tO\nbasal\tO\nextracellular\tO\ndopamine\tO\nlevel\tO\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nas\tO\nwell\tO\nas\tO\ndopamine\tB-Chemical\nrelease\tT-0\nstimulated\tO\neither\tO\nby\tO\nmethamphetamine\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\nor\tO\nby\tO\nintrastriatally\tO\nadministered\tO\nveratridine\tO\n(\tO\n100\tO\nmicroM\tO\n)\tO\n.\tO\n\nA\tO\nsingle\tO\nMPEP\tO\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\ninjection\tO\nreduced\tO\nthe\tO\nbasal\tO\nextracellular\tO\ndopamine\tO\nlevel\tO\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nas\tO\nwell\tO\nas\tO\ndopamine\tO\nrelease\tO\nstimulated\tT-0\neither\tT-0\nby\tT-0\nmethamphetamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\nor\tO\nby\tO\nintrastriatally\tO\nadministered\tO\nveratridine\tO\n(\tO\n100\tO\nmicroM\tO\n)\tO\n.\tO\n\nA\tO\nsingle\tO\nMPEP\tO\n(\tO\n5\tO\nmg\tO\n/\tO\nkg\tO\nip\tO\n)\tO\ninjection\tO\nreduced\tO\nthe\tO\nbasal\tO\nextracellular\tO\ndopamine\tO\nlevel\tO\nin\tO\nthe\tO\nstriatum\tO\n,\tO\nas\tO\nwell\tO\nas\tO\ndopamine\tO\nrelease\tO\nstimulated\tO\neither\tO\nby\tO\nmethamphetamine\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\nor\tO\nby\tO\nintrastriatally\tO\nadministered\tT-0\nveratridine\tB-Chemical\n(\tO\n100\tO\nmicroM\tO\n)\tO\n.\tO\n\nMoreover\tO\n,\tO\nit\tO\ntransiently\tO\ndiminished\tT-0\nthe\tT-0\nmethamphetamine\tB-Chemical\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\n-\tO\ninduced\tO\nhyperthermia\tO\nand\tO\nreduced\tO\nbasal\tO\nbody\tO\ntemperature\tO\n.\tO\n\nMoreover\tO\n,\tO\nit\tO\ntransiently\tO\ndiminished\tO\nthe\tO\nmethamphetamine\tO\n(\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nsc\tO\n)\tO\n-\tO\ninduced\tT-1\nhyperthermia\tB-Disease\nand\tO\nreduced\tO\nbasal\tO\nbody\tO\ntemperature\tO\n.\tO\n\nMPEP\tB-Chemical\nadministered\tT-1\ninto\tO\nthe\tO\nstriatum\tO\nat\tO\nhigh\tO\nconcentrations\tT-2\n(\tO\n500\tO\nmicroM\tO\n)\tO\nincreased\tT-0\nextracellular\tT-0\ndopamine\tT-0\nlevels\tT-0\n,\tO\nwhile\tO\nlower\tO\nconcentrations\tO\n(\tO\n50\tO\n-\tO\n100\tO\nmicroM\tO\n)\tO\nwere\tO\ndevoid\tO\nof\tO\nany\tO\neffect\tO\n.\tO\n\nMPEP\tO\nadministered\tO\ninto\tO\nthe\tO\nstriatum\tO\nat\tO\nhigh\tO\nconcentrations\tO\n(\tO\n500\tO\nmicroM\tO\n)\tO\nincreased\tT-1\nextracellular\tT-1\ndopamine\tB-Chemical\nlevels\tT-2\n,\tO\nwhile\tO\nlower\tT-0\nconcentrations\tT-0\n(\tO\n50\tO\n-\tO\n100\tO\nmicroM\tO\n)\tO\nwere\tO\ndevoid\tO\nof\tO\nany\tO\neffect\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthis\tO\nstudy\tO\nsuggest\tO\nthat\tO\nthe\tO\nblockade\tO\nof\tO\nmGluR5\tO\nby\tT-0\nMPEP\tB-Chemical\nmay\tO\nprotect\tO\ndopaminergic\tO\nneurones\tO\nagainst\tO\nmethamphetamine\tO\n-\tO\ninduced\tO\ntoxicity\tO\n.\tO\n\nThe\tO\nresults\tO\nof\tO\nthis\tO\nstudy\tO\nsuggest\tT-0\nthat\tO\nthe\tO\nblockade\tO\nof\tO\nmGluR5\tO\nby\tO\nMPEP\tO\nmay\tO\nprotect\tO\ndopaminergic\tO\nneurones\tO\nagainst\tO\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tT-2\ntoxicity\tT-2\n.\tT-2\n\nThe\tO\nresults\tO\nof\tO\nthis\tO\nstudy\tO\nsuggest\tO\nthat\tO\nthe\tO\nblockade\tO\nof\tO\nmGluR5\tO\nby\tO\nMPEP\tO\nmay\tO\nprotect\tO\ndopaminergic\tO\nneurones\tO\nagainst\tO\nmethamphetamine\tO\n-\tO\ninduced\tT-0\ntoxicity\tB-Disease\n.\tO\n\nNeuroprotection\tT-2\nrendered\tT-2\nby\tT-2\nMPEP\tB-Chemical\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nreduction\tO\nof\tO\nthe\tO\nmethamphetamine\tO\n-\tO\ninduced\tT-1\ndopamine\tT-1\nefflux\tT-1\nin\tO\nthe\tO\nstriatum\tO\ndue\tO\nto\tO\nthe\tO\nblockade\tO\nof\tO\nextrastriatal\tO\nmGluR5\tO\n,\tO\nand\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\nhyperthermia\tO\n.\tO\n\nNeuroprotection\tT-1\nrendered\tT-1\nby\tT-1\nMPEP\tT-1\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nreduction\tT-0\nof\tT-0\nthe\tT-0\nmethamphetamine\tB-Chemical\n-\tO\ninduced\tO\ndopamine\tO\nefflux\tO\nin\tO\nthe\tO\nstriatum\tO\ndue\tO\nto\tO\nthe\tO\nblockade\tO\nof\tO\nextrastriatal\tO\nmGluR5\tO\n,\tO\nand\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\nhyperthermia\tO\n.\tO\n\nNeuroprotection\tO\nrendered\tO\nby\tO\nMPEP\tO\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nreduction\tO\nof\tO\nthe\tO\nmethamphetamine\tO\n-\tO\ninduced\tT-2\ndopamine\tB-Chemical\nefflux\tT-1\nin\tT-1\nthe\tT-1\nstriatum\tT-1\ndue\tO\nto\tO\nthe\tO\nblockade\tO\nof\tO\nextrastriatal\tO\nmGluR5\tO\n,\tO\nand\tO\nwith\tO\na\tO\ndecrease\tO\nin\tO\nhyperthermia\tO\n.\tO\n\nNeuroprotection\tO\nrendered\tO\nby\tO\nMPEP\tO\nmay\tO\nbe\tO\nassociated\tO\nwith\tO\nthe\tO\nreduction\tO\nof\tO\nthe\tO\nmethamphetamine\tO\n-\tO\ninduced\tO\ndopamine\tO\nefflux\tO\nin\tO\nthe\tO\nstriatum\tO\ndue\tO\nto\tO\nthe\tO\nblockade\tO\nof\tO\nextrastriatal\tO\nmGluR5\tO\n,\tO\nand\tO\nwith\tO\na\tO\ndecrease\tT-0\nin\tT-0\nhyperthermia\tB-Disease\n.\tO\n\nProtective\tT-0\nefficacy\tT-0\nof\tT-0\nneuroactive\tT-0\nsteroids\tB-Chemical\nagainst\tO\ncocaine\tT-1\nkindled\tT-1\n-\tT-1\nseizures\tT-1\nin\tT-1\nmice\tT-1\n.\tT-1\n\nProtective\tT-1\nefficacy\tT-1\nof\tO\nneuroactive\tO\nsteroids\tO\nagainst\tT-2\ncocaine\tB-Chemical\nkindled\tT-0\n-\tT-0\nseizures\tT-0\nin\tT-0\nmice\tT-0\n.\tO\n\nProtective\tO\nefficacy\tT-0\nof\tO\nneuroactive\tO\nsteroids\tO\nagainst\tO\ncocaine\tO\nkindled\tT-1\n-\tO\nseizures\tB-Disease\nin\tO\nmice\tO\n.\tO\n\nNeuroactive\tO\nsteroids\tB-Chemical\ndemonstrate\tT-0\npharmacological\tO\nactions\tO\nthat\tO\nhave\tO\nrelevance\tO\nfor\tO\na\tO\nhost\tO\nof\tO\nneurological\tO\nand\tO\npsychiatric\tO\ndisorders\tO\n.\tO\n\nNeuroactive\tO\nsteroids\tO\ndemonstrate\tT-0\npharmacological\tT-0\nactions\tT-0\nthat\tO\nhave\tO\nrelevance\tO\nfor\tO\na\tO\nhost\tO\nof\tO\nneurological\tB-Disease\nand\tI-Disease\npsychiatric\tI-Disease\ndisorders\tI-Disease\n.\tO\n\nThey\tO\noffer\tO\nprotection\tT-0\nagainst\tT-1\nseizures\tB-Disease\nin\tO\na\tO\nrange\tO\nof\tO\nmodels\tO\nand\tO\nseem\tO\nto\tO\ninhibit\tO\ncertain\tO\nstages\tO\nof\tO\ndrug\tO\ndependence\tO\nin\tO\npreclinical\tO\nassessments\tO\n.\tO\n\nThey\tO\noffer\tO\nprotection\tO\nagainst\tO\nseizures\tO\nin\tO\na\tO\nrange\tO\nof\tO\nmodels\tO\nand\tO\nseem\tO\nto\tO\ninhibit\tT-1\ncertain\tO\nstages\tT-0\nof\tT-0\ndrug\tB-Disease\ndependence\tI-Disease\nin\tO\npreclinical\tO\nassessments\tO\n.\tT-1\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\ntwo\tO\nendogenous\tO\nand\tO\none\tO\nsynthetic\tT-1\nneuroactive\tT-1\nsteroid\tB-Chemical\nthat\tO\npositively\tT-2\nmodulate\tT-2\nthe\tO\ngamma\tO\n-\tO\naminobutyric\tO\nacid\tO\n(\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\n)\tO\nreceptor\tO\nagainst\tO\nthe\tO\nincrease\tO\nin\tO\nsensitivity\tO\nto\tO\nthe\tO\nconvulsant\tO\neffects\tO\nof\tO\ncocaine\tO\nengendered\tO\nby\tO\nrepeated\tO\ncocaine\tO\nadministration\tO\n(\tO\nseizure\tO\nkindling\tO\n)\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\ntwo\tO\nendogenous\tO\nand\tO\none\tO\nsynthetic\tO\nneuroactive\tO\nsteroid\tO\nthat\tO\npositively\tO\nmodulate\tT-1\nthe\tT-1\ngamma\tB-Chemical\n-\tI-Chemical\naminobutyric\tI-Chemical\nacid\tI-Chemical\n(\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\n)\tO\nreceptor\tT-0\nagainst\tT-0\nthe\tT-0\nincrease\tT-0\nin\tO\nsensitivity\tO\nto\tO\nthe\tO\nconvulsant\tO\neffects\tO\nof\tO\ncocaine\tO\nengendered\tO\nby\tO\nrepeated\tO\ncocaine\tO\nadministration\tO\n(\tO\nseizure\tO\nkindling\tO\n)\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tT-0\nto\tT-0\nevaluate\tT-0\ntwo\tO\nendogenous\tO\nand\tO\none\tO\nsynthetic\tO\nneuroactive\tO\nsteroid\tO\nthat\tO\npositively\tT-1\nmodulate\tT-1\nthe\tO\ngamma\tO\n-\tO\naminobutyric\tO\nacid\tO\n(\tO\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\n)\tO\nreceptor\tO\nagainst\tO\nthe\tO\nincrease\tO\nin\tO\nsensitivity\tO\nto\tO\nthe\tO\nconvulsant\tO\neffects\tO\nof\tO\ncocaine\tO\nengendered\tO\nby\tO\nrepeated\tO\ncocaine\tO\nadministration\tO\n(\tO\nseizure\tO\nkindling\tO\n)\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\ntwo\tO\nendogenous\tO\nand\tO\none\tO\nsynthetic\tO\nneuroactive\tO\nsteroid\tO\nthat\tO\npositively\tO\nmodulate\tO\nthe\tO\ngamma\tO\n-\tO\naminobutyric\tO\nacid\tO\n(\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\n)\tO\nreceptor\tO\nagainst\tO\nthe\tO\nincrease\tO\nin\tO\nsensitivity\tO\nto\tO\nthe\tO\nconvulsant\tO\neffects\tT-0\nof\tT-0\ncocaine\tB-Chemical\nengendered\tT-1\nby\tO\nrepeated\tO\ncocaine\tO\nadministration\tO\n(\tO\nseizure\tO\nkindling\tO\n)\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\ntwo\tO\nendogenous\tO\nand\tO\none\tO\nsynthetic\tT-2\nneuroactive\tT-2\nsteroid\tT-2\nthat\tO\npositively\tO\nmodulate\tO\nthe\tO\ngamma\tO\n-\tO\naminobutyric\tO\nacid\tO\n(\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\n)\tO\nreceptor\tO\nagainst\tO\nthe\tO\nincrease\tO\nin\tO\nsensitivity\tO\nto\tO\nthe\tO\nconvulsant\tO\neffects\tT-3\nof\tT-3\ncocaine\tT-0\nengendered\tT-1\nby\tT-1\nrepeated\tT-1\ncocaine\tB-Chemical\nadministration\tO\n(\tO\nseizure\tO\nkindling\tO\n)\tO\n.\tO\n\nThe\tO\npresent\tO\nstudy\tO\nwas\tO\ndesigned\tO\nto\tO\nevaluate\tO\ntwo\tO\nendogenous\tO\nand\tO\none\tO\nsynthetic\tO\nneuroactive\tO\nsteroid\tO\nthat\tO\npositively\tO\nmodulate\tO\nthe\tO\ngamma\tO\n-\tO\naminobutyric\tO\nacid\tO\n(\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\n)\tO\nreceptor\tO\nagainst\tO\nthe\tO\nincrease\tO\nin\tO\nsensitivity\tO\nto\tO\nthe\tO\nconvulsant\tO\neffects\tO\nof\tO\ncocaine\tO\nengendered\tO\nby\tO\nrepeated\tO\ncocaine\tO\nadministration\tT-1\n(\tO\nseizure\tB-Disease\nkindling\tT-0\n)\tO\n.\tO\n\nAllopregnanolone\tB-Chemical\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\n,\tO\npregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5beta\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nand\tO\nganaxolone\tO\n(\tO\na\tO\nsynthetic\tO\nderivative\tO\nof\tO\nallopregnanolone\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n3beta\tO\n-\tO\nmethyl\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nwere\tO\ntested\tO\nfor\tO\ntheir\tO\nability\tT-0\nto\tT-0\nsuppress\tT-0\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tO\n-\tO\nkindled\tO\nseizures\tO\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nAllopregnanolone\tT-0\n(\tO\n3alpha\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n5alpha\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n)\tO\n,\tO\npregnanolone\tT-1\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5beta\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nand\tO\nganaxolone\tO\n(\tO\na\tO\nsynthetic\tO\nderivative\tO\nof\tO\nallopregnanolone\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n3beta\tO\n-\tO\nmethyl\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nwere\tT-2\ntested\tT-2\nfor\tO\ntheir\tO\nability\tO\nto\tO\nsuppress\tO\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tO\n-\tO\nkindled\tO\nseizures\tO\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nAllopregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\n,\tO\npregnanolone\tB-Chemical\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5beta\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nand\tO\nganaxolone\tO\n(\tO\na\tO\nsynthetic\tO\nderivative\tO\nof\tO\nallopregnanolone\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n3beta\tO\n-\tO\nmethyl\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nwere\tO\ntested\tT-0\nfor\tO\ntheir\tO\nability\tO\nto\tO\nsuppress\tO\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tO\n-\tO\nkindled\tO\nseizures\tO\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nAllopregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\n,\tO\npregnanolone\tT-1\n(\tO\n3alpha\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n5beta\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n)\tO\nand\tT-2\nganaxolone\tT-2\n(\tO\na\tO\nsynthetic\tO\nderivative\tO\nof\tO\nallopregnanolone\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n3beta\tO\n-\tO\nmethyl\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nwere\tO\ntested\tO\nfor\tO\ntheir\tO\nability\tO\nto\tO\nsuppress\tO\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tO\n-\tO\nkindled\tO\nseizures\tO\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nAllopregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\n,\tO\npregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5beta\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nand\tO\nganaxolone\tB-Chemical\n(\tO\na\tO\nsynthetic\tO\nderivative\tO\nof\tO\nallopregnanolone\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n3beta\tO\n-\tO\nmethyl\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nwere\tT-1\ntested\tT-1\nfor\tO\ntheir\tO\nability\tO\nto\tO\nsuppress\tT-0\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tO\n-\tO\nkindled\tO\nseizures\tO\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nAllopregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\n,\tO\npregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5beta\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nand\tO\nganaxolone\tO\n(\tO\na\tO\nsynthetic\tO\nderivative\tT-2\nof\tT-2\nallopregnanolone\tB-Chemical\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n3beta\tO\n-\tO\nmethyl\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nwere\tT-3\ntested\tT-3\nfor\tO\ntheir\tO\nability\tT-0\nto\tT-0\nsuppress\tT-0\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tO\n-\tO\nkindled\tT-1\nseizures\tT-1\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nAllopregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\n,\tO\npregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5beta\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nand\tO\nganaxolone\tO\n(\tO\na\tO\nsynthetic\tO\nderivative\tT-0\nof\tT-0\nallopregnanolone\tT-1\n3alpha\tB-Chemical\n-\tI-Chemical\nhydroxy\tI-Chemical\n-\tI-Chemical\n3beta\tI-Chemical\n-\tI-Chemical\nmethyl\tI-Chemical\n-\tI-Chemical\n5alpha\tI-Chemical\n-\tI-Chemical\npregnan\tI-Chemical\n-\tI-Chemical\n20\tI-Chemical\n-\tI-Chemical\none\tI-Chemical\n)\tO\nwere\tT-2\ntested\tT-2\nfor\tO\ntheir\tO\nability\tO\nto\tO\nsuppress\tO\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tO\n-\tO\nkindled\tO\nseizures\tO\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nAllopregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\n,\tO\npregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5beta\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nand\tO\nganaxolone\tO\n(\tO\na\tO\nsynthetic\tO\nderivative\tO\nof\tO\nallopregnanolone\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n3beta\tO\n-\tO\nmethyl\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nwere\tO\ntested\tO\nfor\tO\ntheir\tO\nability\tO\nto\tO\nsuppress\tO\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tB-Chemical\n-\tO\nkindled\tT-0\nseizures\tT-0\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nAllopregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\n,\tO\npregnanolone\tO\n(\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n5beta\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nand\tO\nganaxolone\tO\n(\tO\na\tO\nsynthetic\tO\nderivative\tO\nof\tO\nallopregnanolone\tO\n3alpha\tO\n-\tO\nhydroxy\tO\n-\tO\n3beta\tO\n-\tO\nmethyl\tO\n-\tO\n5alpha\tO\n-\tO\npregnan\tO\n-\tO\n20\tO\n-\tO\none\tO\n)\tO\nwere\tO\ntested\tT-1\nfor\tO\ntheir\tO\nability\tO\nto\tO\nsuppress\tT-2\nthe\tO\nexpression\tO\n(\tO\nanticonvulsant\tO\neffect\tO\n)\tO\nand\tO\ndevelopment\tO\n(\tO\nantiepileptogenic\tO\neffect\tO\n)\tO\nof\tO\ncocaine\tT-0\n-\tT-0\nkindled\tT-0\nseizures\tB-Disease\nin\tO\nmale\tO\n,\tO\nSwiss\tO\n-\tO\nWebster\tO\nmice\tO\n.\tO\n\nKindled\tT-1\nseizures\tB-Disease\nwere\tT-1\ninduced\tT-1\nby\tO\ndaily\tO\nadministration\tO\nof\tO\n60\tO\nmg\tO\n/\tO\nkg\tO\ncocaine\tO\nfor\tO\n5\tO\ndays\tO\n.\tO\n\nKindled\tO\nseizures\tO\nwere\tO\ninduced\tO\nby\tO\ndaily\tO\nadministration\tT-0\nof\tT-0\n60\tO\nmg\tO\n/\tO\nkg\tO\ncocaine\tB-Chemical\nfor\tO\n5\tO\ndays\tO\n.\tO\n\nAll\tO\nof\tO\nthese\tO\npositive\tT-0\nGABA\tB-Chemical\n(\tO\nA\tO\n)\tO\nmodulators\tT-1\nsuppressed\tO\nthe\tO\nexpression\tO\nof\tO\nkindled\tO\nseizures\tO\n,\tO\nwhereas\tO\nonly\tO\nallopregnanolone\tO\nand\tO\nganaxolone\tO\ninhibited\tO\nthe\tO\ndevelopment\tO\nof\tO\nkindling\tO\n.\tO\n\nAll\tO\nof\tO\nthese\tO\npositive\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nmodulators\tO\nsuppressed\tO\nthe\tO\nexpression\tO\nof\tO\nkindled\tT-0\nseizures\tB-Disease\n,\tO\nwhereas\tO\nonly\tO\nallopregnanolone\tO\nand\tO\nganaxolone\tO\ninhibited\tO\nthe\tO\ndevelopment\tO\nof\tO\nkindling\tO\n.\tO\n\nAll\tO\nof\tO\nthese\tO\npositive\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nmodulators\tO\nsuppressed\tO\nthe\tO\nexpression\tO\nof\tO\nkindled\tO\nseizures\tO\n,\tO\nwhereas\tO\nonly\tO\nallopregnanolone\tB-Chemical\nand\tO\nganaxolone\tO\ninhibited\tT-0\nthe\tO\ndevelopment\tO\nof\tO\nkindling\tO\n.\tO\n\nAll\tO\nof\tO\nthese\tO\npositive\tO\nGABA\tO\n(\tO\nA\tO\n)\tO\nmodulators\tO\nsuppressed\tO\nthe\tO\nexpression\tO\nof\tO\nkindled\tO\nseizures\tO\n,\tO\nwhereas\tO\nonly\tO\nallopregnanolone\tO\nand\tO\nganaxolone\tB-Chemical\ninhibited\tT-1\nthe\tT-1\ndevelopment\tT-1\nof\tT-1\nkindling\tT-1\n.\tO\n\nAllopregnanolone\tB-Chemical\nand\tO\npregnanolone\tO\n,\tO\nbut\tO\nnot\tO\nganaxolone\tO\n,\tO\nalso\tO\nreduced\tT-0\ncumulative\tO\nlethality\tO\nassociated\tT-1\nwith\tO\nkindling\tO\n.\tO\n\nAllopregnanolone\tT-3\nand\tT-3\npregnanolone\tB-Chemical\n,\tO\nbut\tT-4\nnot\tT-4\nganaxolone\tT-4\n,\tO\nalso\tO\nreduced\tT-0\ncumulative\tT-0\nlethality\tT-0\nassociated\tO\nwith\tO\nkindling\tO\n.\tO\n\nAllopregnanolone\tO\nand\tO\npregnanolone\tO\n,\tO\nbut\tO\nnot\tT-1\nganaxolone\tB-Chemical\n,\tO\nalso\tT-0\nreduced\tT-0\ncumulative\tO\nlethality\tO\nassociated\tO\nwith\tO\nkindling\tO\n.\tO\n\nThese\tO\nfindings\tO\ndemonstrate\tO\nthat\tO\nsome\tO\nneuroactive\tO\nsteroids\tB-Chemical\nattenuate\tO\nconvulsant\tO\nand\tO\nsensitizing\tO\nproperties\tO\nof\tO\ncocaine\tO\nand\tO\nadd\tO\nto\tO\na\tO\ngrowing\tO\nliterature\tO\non\tO\ntheir\tO\npotential\tO\nuse\tT-0\nin\tO\nthe\tO\nmodulation\tO\nof\tO\neffects\tO\nof\tO\ndrugs\tT-1\nof\tO\nabuse\tO\n.\tO\n\nThese\tO\nfindings\tO\ndemonstrate\tO\nthat\tO\nsome\tO\nneuroactive\tO\nsteroids\tO\nattenuate\tO\nconvulsant\tO\nand\tO\nsensitizing\tO\nproperties\tT-0\nof\tT-0\ncocaine\tB-Chemical\nand\tO\nadd\tO\nto\tO\na\tO\ngrowing\tO\nliterature\tO\non\tO\ntheir\tO\npotential\tO\nuse\tO\nin\tO\nthe\tO\nmodulation\tO\nof\tO\neffects\tO\nof\tO\ndrugs\tO\nof\tO\nabuse\tO\n.\tO\n\nEffect\tO\nof\tO\nhumoral\tT-0\nmodulators\tT-2\nof\tT-2\nmorphine\tB-Chemical\n-\tO\ninduced\tT-3\nincrease\tT-3\nin\tO\nlocomotor\tO\nactivity\tO\nof\tO\nmice\tO\n.\tO\n\nEffect\tO\nof\tO\nhumoral\tO\nmodulators\tO\nof\tO\nmorphine\tO\n-\tO\ninduced\tT-0\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nof\tO\nmice\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nhumoral\tO\nmodulators\tO\non\tO\nthe\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tT-0\nincrease\tO\nin\tO\nlocomotor\tO\nactivity\tO\nof\tO\nmice\tO\nwas\tO\nstudied\tO\n.\tO\n\nThe\tO\neffect\tO\nof\tO\nhumoral\tO\nmodulators\tO\non\tO\nthe\tO\nmorphine\tO\n-\tO\ninduced\tT-0\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nof\tO\nmice\tO\nwas\tO\nstudied\tO\n.\tO\n\nThe\tO\nsubcutaneous\tO\nadministration\tT-1\nof\tT-1\n10\tO\nmg\tO\n/\tO\nkg\tO\nof\tO\nmorphine\tB-Chemical\n-\tO\nHC1\tO\nproduced\tT-2\na\tO\nmarked\tO\nincrease\tO\nin\tO\nlocomotor\tO\nactivity\tO\nin\tO\nmice\tO\n.\tO\n\nThe\tO\nsubcutaneous\tO\nadministration\tO\nof\tO\n10\tO\nmg\tO\n/\tO\nkg\tO\nof\tO\nmorphine\tO\n-\tO\nHC1\tO\nproduced\tT-1\na\tT-0\nmarked\tT-2\nincrease\tB-Disease\nin\tI-Disease\nlocomotor\tI-Disease\nactivity\tI-Disease\nin\tO\nmice\tO\n.\tO\n\nThe\tO\nmorphine\tB-Chemical\n-\tO\ninduced\tT-0\nhyperactivity\tO\nwas\tO\npotentiated\tO\nby\tO\nscopolamine\tO\nand\tO\nattenuated\tO\nby\tO\nphysostigmine\tO\n.\tO\n\nThe\tO\nmorphine\tT-0\n-\tT-0\ninduced\tT-0\nhyperactivity\tB-Disease\nwas\tT-1\npotentiated\tT-1\nby\tO\nscopolamine\tO\nand\tO\nattenuated\tO\nby\tO\nphysostigmine\tO\n.\tO\n\nThe\tO\nmorphine\tO\n-\tO\ninduced\tO\nhyperactivity\tO\nwas\tO\npotentiated\tT-1\nby\tT-1\nscopolamine\tB-Chemical\nand\tO\nattenuated\tT-0\nby\tT-0\nphysostigmine\tO\n.\tO\n\nThe\tO\nmorphine\tO\n-\tO\ninduced\tO\nhyperactivity\tO\nwas\tO\npotentiated\tO\nby\tO\nscopolamine\tO\nand\tO\nattenuated\tT-0\nby\tT-0\nphysostigmine\tB-Chemical\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nboth\tT-0\nmethscopolamine\tB-Chemical\nand\tO\nneostigmine\tO\n,\tO\nwhich\tT-1\ndo\tT-1\nnot\tT-1\npenetrate\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n,\tO\nhad\tT-2\nno\tT-2\neffect\tT-2\non\tO\nthe\tO\nhyperactivity\tO\nproduced\tO\nby\tO\nmorphine\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nboth\tO\nmethscopolamine\tT-1\nand\tT-1\nneostigmine\tB-Chemical\n,\tO\nwhich\tO\ndo\tO\nnot\tO\npenetrate\tT-2\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n,\tO\nhad\tT-0\nno\tT-0\neffect\tT-3\non\tT-3\nthe\tO\nhyperactivity\tO\nproduced\tO\nby\tO\nmorphine\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nboth\tO\nmethscopolamine\tO\nand\tO\nneostigmine\tO\n,\tO\nwhich\tO\ndo\tO\nnot\tO\npenetrate\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n,\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nhyperactivity\tB-Disease\nproduced\tT-0\nby\tO\nmorphine\tO\n.\tO\n\nIn\tO\ncontrast\tO\n,\tO\nboth\tO\nmethscopolamine\tO\nand\tO\nneostigmine\tO\n,\tO\nwhich\tO\ndo\tO\nnot\tO\npenetrate\tO\nthe\tO\nblood\tO\n-\tO\nbrain\tO\nbarrier\tO\n,\tO\nhad\tO\nno\tO\neffect\tO\non\tO\nthe\tO\nhyperactivity\tO\nproduced\tT-1\nby\tT-1\nmorphine\tB-Chemical\n.\tO\n\nPretreatment\tT-1\nof\tO\nmice\tT-0\nwith\tT-0\nalpha\tB-Chemical\n-\tI-Chemical\nmethyltyrosine\tI-Chemical\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\none\tO\nhour\tO\n)\tO\n,\tO\nan\tO\ninhibitor\tT-2\nof\tT-2\ntyrosine\tT-2\nhydroxylase\tT-2\n,\tO\nsignificantly\tO\ndecreased\tO\nthe\tO\nactivity\tO\n-\tO\nincreasing\tO\neffects\tO\nof\tO\nmorphine\tO\n.\tO\n\nPretreatment\tT-0\nof\tO\nmice\tO\nwith\tO\nalpha\tO\n-\tO\nmethyltyrosine\tO\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\none\tO\nhour\tO\n)\tO\n,\tO\nan\tT-1\ninhibitor\tT-3\nof\tT-3\ntyrosine\tB-Chemical\nhydroxylase\tO\n,\tO\nsignificantly\tT-2\ndecreased\tT-2\nthe\tT-2\nactivity\tT-2\n-\tO\nincreasing\tO\neffects\tO\nof\tO\nmorphine\tO\n.\tO\n\nPretreatment\tO\nof\tO\nmice\tO\nwith\tO\nalpha\tO\n-\tO\nmethyltyrosine\tO\n(\tO\n20\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\none\tO\nhour\tO\n)\tO\n,\tO\nan\tO\ninhibitor\tO\nof\tO\ntyrosine\tO\nhydroxylase\tO\n,\tO\nsignificantly\tO\ndecreased\tO\nthe\tO\nactivity\tO\n-\tO\nincreasing\tO\neffects\tT-0\nof\tT-0\nmorphine\tB-Chemical\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\npretreatment\tT-0\nwith\tO\np\tB-Chemical\n-\tI-Chemical\nchlorophenylalamine\tI-Chemical\n(\tO\n3\tO\nX\tO\n320\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\n24\tO\nhr\tO\n)\tO\n,\tO\na\tO\nserotonin\tO\ndepletor\tO\n,\tO\ncaused\tT-1\nno\tO\nsignificant\tO\nchange\tO\nin\tO\nthe\tO\nhyperactivity\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\npretreatment\tT-0\nwith\tT-0\np\tO\n-\tO\nchlorophenylalamine\tO\n(\tO\n3\tO\nX\tO\n320\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\n24\tO\nhr\tO\n)\tO\n,\tO\na\tO\nserotonin\tB-Chemical\ndepletor\tO\n,\tO\ncaused\tT-1\nno\tO\nsignificant\tO\nchange\tO\nin\tO\nthe\tO\nhyperactivity\tO\n.\tO\n\nOn\tO\nthe\tO\nother\tO\nhand\tO\n,\tO\npretreatment\tO\nwith\tO\np\tO\n-\tO\nchlorophenylalamine\tO\n(\tO\n3\tO\nX\tO\n320\tO\nmg\tO\n/\tO\nkg\tO\ni\tO\n.\tO\np\tO\n.\tO\n,\tO\n24\tO\nhr\tO\n)\tO\n,\tO\na\tO\nserotonin\tO\ndepletor\tO\n,\tO\ncaused\tT-1\nno\tT-0\nsignificant\tT-0\nchange\tT-0\nin\tT-0\nthe\tT-0\nhyperactivity\tB-Disease\n.\tO\n\n"
  },
  {
    "path": "dataset/CONLL/dev.txt",
    "content": "CRICKET O\n- O\nLEICESTERSHIRE B-ORG\nTAKE O\nOVER O\nAT O\nTOP O\nAFTER O\nINNINGS O\nVICTORY O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nWest B-MISC\nIndian I-MISC\nall-rounder O\nPhil B-PER\nSimmons I-PER\ntook O\nfour O\nfor O\n38 O\non O\nFriday O\nas O\nLeicestershire B-ORG\nbeat O\nSomerset B-ORG\nby O\nan O\ninnings O\nand O\n39 O\nruns O\nin O\ntwo O\ndays O\nto O\ntake O\nover O\nat O\nthe O\nhead O\nof O\nthe O\ncounty O\nchampionship O\n. O\n\nTheir O\nstay O\non O\ntop O\n, O\nthough O\n, O\nmay O\nbe O\nshort-lived O\nas O\ntitle O\nrivals O\nEssex B-ORG\n, O\nDerbyshire B-ORG\nand O\nSurrey B-ORG\nall O\nclosed O\nin O\non O\nvictory O\nwhile O\nKent B-ORG\nmade O\nup O\nfor O\nlost O\ntime O\nin O\ntheir O\nrain-affected O\nmatch O\nagainst O\nNottinghamshire B-ORG\n. O\n\nAfter O\nbowling O\nSomerset B-ORG\nout O\nfor O\n83 O\non O\nthe O\nopening O\nmorning O\nat O\nGrace B-LOC\nRoad I-LOC\n, O\nLeicestershire B-ORG\nextended O\ntheir O\nfirst O\ninnings O\nby O\n94 O\nruns O\nbefore O\nbeing O\nbowled O\nout O\nfor O\n296 O\nwith O\nEngland B-LOC\ndiscard O\nAndy B-PER\nCaddick I-PER\ntaking O\nthree O\nfor O\n83 O\n. O\n\nTrailing O\nby O\n213 O\n, O\nSomerset B-ORG\ngot O\na O\nsolid O\nstart O\nto O\ntheir O\nsecond O\ninnings O\nbefore O\nSimmons B-PER\nstepped O\nin O\nto O\nbundle O\nthem O\nout O\nfor O\n174 O\n. O\n\nEssex B-ORG\n, O\nhowever O\n, O\nlook O\ncertain O\nto O\nregain O\ntheir O\ntop O\nspot O\nafter O\nNasser B-PER\nHussain I-PER\nand O\nPeter B-PER\nSuch I-PER\ngave O\nthem O\na O\nfirm O\ngrip O\non O\ntheir O\nmatch O\nagainst O\nYorkshire B-ORG\nat O\nHeadingley B-LOC\n. O\n\nHussain B-PER\n, O\nconsidered O\nsurplus O\nto O\nEngland B-LOC\n's O\none-day O\nrequirements O\n, O\nstruck O\n158 O\n, O\nhis O\nfirst O\nchampionship O\ncentury O\nof O\nthe O\nseason O\n, O\nas O\nEssex B-ORG\nreached O\n372 O\nand O\ntook O\na O\nfirst O\ninnings O\nlead O\nof O\n82 O\n. O\n\nBy O\nthe O\nclose O\nYorkshire B-ORG\nhad O\nturned O\nthat O\ninto O\na O\n37-run O\nadvantage O\nbut O\noff-spinner O\nSuch B-PER\nhad O\nscuttled O\ntheir O\nhopes O\n, O\ntaking O\nfour O\nfor O\n24 O\nin O\n48 O\nballs O\nand O\nleaving O\nthem O\nhanging O\non O\n119 O\nfor O\nfive O\nand O\npraying O\nfor O\nrain O\n. O\n\nAt O\nthe O\nOval B-LOC\n, O\nSurrey B-ORG\ncaptain O\nChris B-PER\nLewis I-PER\n, O\nanother O\nman O\ndumped O\nby O\nEngland B-LOC\n, O\ncontinued O\nto O\nsilence O\nhis O\ncritics O\nas O\nhe O\nfollowed O\nhis O\nfour O\nfor O\n45 O\non O\nThursday O\nwith O\n80 O\nnot O\nout O\non O\nFriday O\nin O\nthe O\nmatch O\nagainst O\nWarwickshire B-ORG\n. O\n\nHe O\nwas O\nwell O\nbacked O\nby O\nEngland B-LOC\nhopeful O\nMark B-PER\nButcher I-PER\nwho O\nmade O\n70 O\nas O\nSurrey B-ORG\nclosed O\non O\n429 O\nfor O\nseven O\n, O\na O\nlead O\nof O\n234 O\n. O\n\nDerbyshire B-ORG\nkept O\nup O\nthe O\nhunt O\nfor O\ntheir O\nfirst O\nchampionship O\ntitle O\nsince O\n1936 O\nby O\nreducing O\nWorcestershire B-ORG\nto O\n133 O\nfor O\nfive O\nin O\ntheir O\nsecond O\ninnings O\n, O\nstill O\n100 O\nruns O\naway O\nfrom O\navoiding O\nan O\ninnings O\ndefeat O\n. O\n\nAustralian B-MISC\nTom B-PER\nMoody I-PER\ntook O\nsix O\nfor O\n82 O\nbut O\nChris B-PER\nAdams I-PER\n, O\n123 O\n, O\nand O\nTim B-PER\nO'Gorman I-PER\n, O\n109 O\n, O\ntook O\nDerbyshire B-ORG\nto O\n471 O\nand O\na O\nfirst O\ninnings O\nlead O\nof O\n233 O\n. O\n\nAfter O\nthe O\nfrustration O\nof O\nseeing O\nthe O\nopening O\nday O\nof O\ntheir O\nmatch O\nbadly O\naffected O\nby O\nthe O\nweather O\n, O\nKent B-ORG\nstepped O\nup O\na O\ngear O\nto O\ndismiss O\nNottinghamshire B-ORG\nfor O\n214 O\n. O\n\nThey O\nwere O\nheld O\nup O\nby O\na O\ngritty O\n84 O\nfrom O\nPaul B-PER\nJohnson I-PER\nbut O\nex-England B-MISC\nfast O\nbowler O\nMartin B-PER\nMcCague I-PER\ntook O\nfour O\nfor O\n55 O\n. O\n\nBy O\nstumps O\nKent B-ORG\nhad O\nreached O\n108 O\nfor O\nthree O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLISH B-MISC\nCOUNTY I-MISC\nCHAMPIONSHIP I-MISC\nSCORES O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nResult O\nand O\nclose O\nof O\nplay O\nscores O\nin O\nEnglish B-MISC\ncounty O\nchampionship O\nmatches O\non O\nFriday O\n: O\n\nLeicester B-LOC\n: O\nLeicestershire B-ORG\nbeat O\nSomerset B-ORG\nby O\nan O\ninnings O\nand O\n39 O\nruns O\n. O\n\nSomerset B-ORG\n83 O\nand O\n174 O\n( O\nP. B-PER\nSimmons I-PER\n4-38 O\n) O\n, O\nLeicestershire B-ORG\n296 O\n. O\n\nLeicestershire B-ORG\n22 O\npoints O\n, O\nSomerset B-ORG\n4 O\n. O\n\nChester-le-Street B-LOC\n: O\nGlamorgan B-ORG\n259 O\nand O\n207 O\n( O\nA. B-PER\nDale I-PER\n69 O\n, O\nH. B-PER\nMorris I-PER\n69 O\n; O\nD. B-PER\nBlenkiron I-PER\n4-43 O\n) O\n, O\nDurham B-ORG\n114 O\n( O\nS. B-PER\nWatkin I-PER\n4-28 O\n) O\nand O\n81-3 O\n. O\n\nTunbridge B-LOC\nWells I-LOC\n: O\nNottinghamshire B-ORG\n214 O\n( O\nP. B-PER\nJohnson I-PER\n84 O\n; O\nM. B-PER\nMcCague I-PER\n4-55 O\n) O\n, O\nKent B-ORG\n108-3 O\n. O\n\nLondon B-LOC\n( O\nThe B-LOC\nOval I-LOC\n) O\n: O\nWarwickshire B-ORG\n195 O\n, O\nSurrey B-ORG\n429-7 O\n( O\nC. B-PER\nLewis I-PER\n80 O\nnot O\nout O\n, O\nM. B-PER\nButcher I-PER\n70 O\n, O\nG. B-PER\nKersey I-PER\n63 O\n, O\nJ. B-PER\nRatcliffe I-PER\n63 O\n, O\nD. B-PER\nBicknell I-PER\n55 O\n) O\n. O\n\nHove B-LOC\n: O\nSussex B-ORG\n363 O\n( O\nW. B-PER\nAthey I-PER\n111 O\n, O\nV. B-PER\nDrakes I-PER\n52 O\n; O\nI. B-PER\nAustin I-PER\n4-37 O\n) O\n, O\nLancashire B-ORG\n197-8 O\n( O\nW. B-PER\nHegg I-PER\n54 O\n) O\n\nPortsmouth B-LOC\n: O\nMiddlesex B-ORG\n199 O\nand O\n426 O\n( O\nJ. B-PER\nPooley I-PER\n111 O\n, O\nM. B-PER\nRamprakash I-PER\n108 O\n, O\nM. B-PER\nGatting I-PER\n83 O\n) O\n, O\nHampshire B-ORG\n232 O\nand O\n109-5 O\n. O\n\nChesterfield B-LOC\n: O\nWorcestershire B-ORG\n238 O\nand O\n133-5 O\n, O\nDerbyshire B-ORG\n471 O\n( O\nJ. B-PER\nAdams I-PER\n123 O\n, O\nT.O'Gorman B-PER\n109 O\nnot O\nout O\n, O\nK. B-PER\nBarnett I-PER\n87 O\n; O\nT. B-PER\nMoody I-PER\n6-82 O\n) O\n\nBristol B-LOC\n: O\nGloucestershire B-ORG\n183 O\nand O\n185-6 O\n( O\nJ. B-PER\nRussell I-PER\n56 O\nnot O\nout O\n) O\n, O\nNorthamptonshire B-ORG\n190 O\n( O\nK. B-PER\nCurran I-PER\n52 O\n; O\nA. B-PER\nSmith I-PER\n5-68 O\n) O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\n1997 O\nASHES B-MISC\nINTINERARY O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nAustralia B-LOC\nwill O\ndefend O\nthe O\nAshes B-MISC\nin O\n\na O\nsix-test O\nseries O\nagainst O\nEngland B-LOC\nduring O\na O\nfour-month O\ntour O\n\nstarting O\non O\nMay O\n13 O\nnext O\nyear O\n, O\nthe O\nTest B-ORG\nand I-ORG\nCounty I-ORG\nCricket I-ORG\nBoard I-ORG\n\nsaid O\non O\nFriday O\n. O\n\nAustralia B-LOC\nwill O\nalso O\nplay O\nthree O\none-day O\ninternationals O\nand O\n\nfour O\none-day O\nwarm-up O\nmatches O\nat O\nthe O\nstart O\nof O\nthe O\ntour O\n. O\n\nThe O\ntourists O\nwill O\nplay O\nnine O\nfirst-class O\nmatches O\nagainst O\n\nEnglish B-MISC\ncounty O\nsides O\nand O\nanother O\nagainst O\nBritish B-ORG\nUniversities I-ORG\n, O\n\nas O\nwell O\nas O\none-day O\nmatches O\nagainst O\nthe O\nMinor B-ORG\nCounties I-ORG\nand O\n\nScotland B-LOC\n. O\n\nTour O\nitinerary O\n: O\n\nMay O\n\nMay O\n13 O\nArrive O\nin O\nLondon B-LOC\n\nMay O\n14 O\nPractice O\nat O\nLord B-LOC\n's I-LOC\n\nMay O\n15 O\nv O\nDuke B-ORG\nof I-ORG\nNorfolk I-ORG\n's I-ORG\nXI I-ORG\n( O\nat O\nArundel B-LOC\n) O\n\nMay O\n17 O\nv O\nNorthampton B-ORG\n\nMay O\n18 O\nv O\nWorcestershire B-ORG\n\nMay O\n20 O\nv O\nDurham B-ORG\n\nMay O\n22 O\nFirst O\none-day O\ninternational O\n( O\nat O\nHeadingley B-LOC\n, O\n\nLeeds B-ORG\n) O\n\nMay O\n24 O\nSecond O\none-day O\ninternational O\n( O\nat O\nThe B-LOC\nOval I-LOC\n, O\n\nLondon B-LOC\n) O\n\nMay O\n25 O\nThird O\none-day O\ninternational O\n( O\nat O\nLord B-LOC\n's I-LOC\n, O\nLondon B-LOC\n) O\n\nMay O\n27-29 O\nv O\nGloucestershire B-ORG\nor O\nSussex B-ORG\nor O\nSurrey B-ORG\n( O\nthree O\n\ndays O\n) O\n\nMay O\n31 O\n- O\nJune O\n2 O\nv O\nDerbyshire B-ORG\n( O\nthree O\ndays O\n) O\n\nJune O\n\nJune O\n5-9 O\nFirst O\ntest O\nmatch O\n( O\nat O\nEdgbaston B-LOC\n, O\nBirmingham B-LOC\n) O\n\nJune O\n11-13 O\nv O\na O\nfirst O\nclass O\ncounty O\n( O\nto O\nbe O\nconfirmed O\n) O\n\nJune O\n14-16 O\nv O\nLeicestershire B-ORG\n( O\nthree O\ndays O\n) O\n\nJune O\n19-23 O\nSecond O\ntest O\n( O\nat O\nLord B-LOC\n's I-LOC\n) O\n\nJune O\n25-27 O\nv O\nBritish B-ORG\nUniversities I-ORG\n( O\nat O\nOxford B-LOC\n, O\nthree O\ndays O\n) O\n\nJune O\n28-30 O\nv O\nHampshire B-ORG\n( O\nthree O\ndays O\n) O\n\nJuly O\n\nJuly O\n3-7 O\nThird O\ntest O\n( O\nat O\nOld B-LOC\nTrafford I-LOC\n, O\nManchester B-LOC\n) O\n\nJuly O\n9 O\nv O\nMinor B-ORG\nCounties I-ORG\nXI I-ORG\n\nJuly O\n12 O\nv O\nScotland B-LOC\n\nJuly O\n16-18 O\nv O\nGlamorgan B-ORG\n( O\nthree O\ndays O\n) O\n\nJuly O\n19-21 O\nv O\nMiddlesex B-ORG\n( O\nthree O\ndays O\n) O\n\nJuly O\n24-28 O\nFourth O\ntest O\n( O\nat O\nHeadingley B-LOC\n) O\n\nAugust O\n\nAugust O\n1-4 O\nv O\nSomerset B-ORG\n( O\nfour O\ndays O\n) O\n\nAugust O\n7-11 O\nFifth O\ntest O\n( O\nat O\nTrent B-LOC\nBridge I-LOC\n, O\nNottingham B-LOC\n) O\n\nAugust O\n16-18 O\nv O\nKent B-ORG\n( O\nthree O\ndays O\n) O\n\nAugust O\n21-25 O\nSixth O\ntest O\n( O\nat O\nThe B-LOC\nOval I-LOC\n, O\nLondon B-LOC\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSHEARER B-PER\nNAMED O\nAS O\nENGLAND B-LOC\nCAPTAIN O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nThe O\nworld O\n's O\ncostliest O\nfootballer O\nAlan B-PER\nShearer I-PER\nwas O\nnamed O\nas O\nthe O\nnew O\nEngland B-LOC\ncaptain O\non O\nFriday O\n. O\n\nThe O\n26-year-old O\n, O\nwho O\njoined O\nNewcastle B-ORG\nfor O\n15 O\nmillion O\npounds O\nsterling O\n( O\n$ O\n23.4 O\nmillion O\n) O\n, O\ntakes O\nover O\nfrom O\nTony B-PER\nAdams I-PER\n, O\nwho O\nled O\nthe O\nside O\nduring O\nthe O\nEuropean B-MISC\nchampionship O\nin O\nJune O\n, O\nand O\nformer O\ncaptain O\nDavid B-PER\nPlatt I-PER\n. O\n\nAdams B-PER\nand O\nPlatt B-PER\nare O\nboth O\ninjured O\nand O\nwill O\nmiss O\nEngland B-LOC\n's O\nopening O\nWorld B-MISC\nCup I-MISC\nqualifier O\nagainst O\nMoldova B-LOC\non O\nSunday O\n. O\n\nShearer B-PER\ntakes O\nthe O\ncaptaincy O\non O\na O\ntrial O\nbasis O\n, O\nbut O\nnew O\ncoach O\nGlenn B-PER\nHoddle I-PER\nsaid O\nhe O\nsaw O\nno O\nreason O\nwhy O\nthe O\nformer O\nBlackburn B-ORG\nand O\nSouthampton B-ORG\nskipper O\nshould O\nnot O\nmake O\nthe O\npost O\nhis O\nown O\n. O\n\n\" O\nI O\n'm O\nsure O\nthere O\nwo O\nn't O\nbe O\na O\nproblem O\n, O\nI O\n'm O\nsure O\nAlan B-PER\nis O\nthe O\nman O\nfor O\nthe O\njob O\n, O\n\" O\nHoddle B-PER\nsaid O\n. O\n\n\" O\nThere O\nwere O\nthree O\nor O\nfour O\npeople O\nwho O\ncould O\nhave O\ndone O\nit O\nbut O\nwhen O\nI O\nspoke O\nto O\nAlan B-PER\nhe O\nwas O\nup O\nfor O\nit O\nand O\nreally O\nwanted O\nit O\n. O\n\n\" O\nIn O\nfour O\ndays O\nit O\n's O\nvery O\ndifficult O\nto O\ncome O\nto O\na O\n100 O\npercent O\nconclusion O\nabout O\nsomething O\nlike O\nthis O\n... O\n\nbut O\nhe O\nknows O\nhow O\nto O\nconduct O\nhimself O\n, O\nhis O\nteam O\nmates O\nrespect O\nhim O\nand O\nhe O\nknows O\nabout O\nthe O\nteam O\nsituation O\neven O\nthough O\nhe O\nplays O\nup O\nfront O\n. O\n\" O\n\nShearer B-PER\n's O\nEuro B-MISC\n96 I-MISC\nstriking O\npartner O\nTeddy B-PER\nSheringham I-PER\nwithdrew O\nfrom O\nthe O\nsquad O\nwith O\nan O\ninjury O\non O\nFriday O\n. O\n\nHe O\nwill O\nprobably O\nbe O\nreplaced O\nby O\nShearer B-PER\n's O\nNewcastle B-ORG\nteam O\nmate O\nLes B-PER\nFerdinand I-PER\n. O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nINTERNATIONAL O\nTOURNAMENT O\nRESULT O\n. O\n\nBELGRADE B-LOC\n1996-08-30 O\n\nResult O\nin O\nan O\ninternational O\n\nbasketball O\ntournament O\non O\nFriday O\n: O\n\nRed B-ORG\nStar I-ORG\n( O\nYugoslavia B-LOC\n) O\nbeat O\nDinamo B-ORG\n( O\nRussia B-LOC\n) O\n92-90 O\n( O\nhalftime O\n\n47-47 O\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nROMANIA B-LOC\nBEAT O\nLITHUANIA B-LOC\nIN O\nUNDER-21 O\nMATCH O\n. O\n\nBUCHAREST B-LOC\n1996-08-30 O\n\nRomania B-LOC\nbeat O\nLithuania B-LOC\n2-1 O\n( O\nhalftime O\n1-1 O\n) O\nin O\ntheir O\nEuropean B-MISC\nunder-21 O\nsoccer O\nmatch O\non O\nFriday O\n. O\n\nScorers O\n: O\n\nRomania B-LOC\n- O\nCosmin B-PER\nContra I-PER\n( O\n31st O\n) O\n, O\nMihai B-PER\nTararache I-PER\n( O\n75th O\n) O\n\nLithuania B-LOC\n- O\nDanius B-PER\nGleveckas I-PER\n( O\n13rd O\n) O\n\nAttendance O\n: O\n200 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nROTOR B-ORG\nFANS O\nLOCKED O\nOUT O\nAFTER O\nVOLGOGRAD B-LOC\nVIOLENCE O\n. O\n\nMOSCOW B-LOC\n1996-08-30 O\n\nRotor B-ORG\nVolgograd I-ORG\nmust O\nplay O\ntheir O\nnext O\nhome O\ngame O\nbehind O\nclosed O\ndoors O\nafter O\nfans O\nhurled O\nbottles O\nand O\nstones O\nat O\nDynamo B-ORG\nMoscow I-ORG\nplayers O\nduring O\na O\n1-0 O\nhome O\ndefeat O\non O\nSaturday O\nthat O\nended O\nRotor B-ORG\n's O\nbrief O\nspell O\nas O\nleague O\nleaders O\n. O\n\nThe O\nhead O\nof O\nthe O\nRussian B-MISC\nleague O\n's O\ndisciplinary O\ncommittee O\n, O\nAnatoly B-PER\nGorokhovsky I-PER\n, O\nsaid O\non O\nFriday O\nthat O\nRotor B-ORG\nwould O\nplay O\nLada B-ORG\nTogliatti I-ORG\nto O\nempty O\nstands O\non O\nSeptember O\n3 O\n. O\n\nThe O\nclub O\n, O\nwho O\nput O\nManchester B-ORG\nUnited I-ORG\nout O\nof O\nlast O\nyear O\n's O\nUEFA B-MISC\nCup I-MISC\n, O\nwere O\nfined O\n$ O\n1,000 O\n. O\n\nDespite O\nthe O\ndefeat O\n, O\nRotor B-ORG\nare O\nwell O\nplaced O\nwith O\n11 O\ngames O\nto O\nplay O\nin O\nthe O\nchampionship O\n. O\n\nLying O\nthree O\npoints O\nbehind O\nAlania B-ORG\nand O\ntwo O\nbehind O\nDynamo B-ORG\nMoscow I-ORG\n, O\nthe O\nVolgograd B-LOC\nside O\nhave O\na O\ngame O\nin O\nhand O\nover O\nthe O\nleaders O\nand O\ntwo O\nover O\nthe O\nMoscow B-LOC\nclub O\n. O\n\n-DOCSTART- O\n\nBOXING O\n- O\nPANAMA B-LOC\n'S O\nROBERTO B-PER\nDURAN I-PER\nFIGHTS O\nTHE O\nSANDS O\nOF O\nTIME O\n. O\n\nPANAMA B-LOC\nCITY I-LOC\n1996-08-30 O\n\nPanamanian B-MISC\nboxing O\nlegend O\nRoberto B-PER\n\" I-PER\nHands I-PER\nof I-PER\nStone I-PER\n\" I-PER\nDuran I-PER\nclimbs O\ninto O\nthe O\nring O\non O\nSaturday O\nin O\nanother O\nage-defying O\nattempt O\nto O\nsustain O\nhis O\nlong O\ncareer O\n. O\n\nDuran B-PER\n, O\n45 O\n, O\ntakes O\non O\nlittle-known O\nMexican B-MISC\nAriel B-PER\nCruz I-PER\n, O\n30 O\n, O\nin O\na O\nsuper O\nmiddleweight O\nnon-title O\nbout O\nin O\nPanama B-LOC\nCity I-LOC\n. O\n\nThe O\nfight O\n, O\nDuran B-PER\n's O\nfirst O\non O\nhome O\nsoil O\nfor O\n10 O\nyears O\n, O\nis O\nbeing O\nbilled O\nhere O\nas O\nthe O\n\" O\nReturn B-MISC\nof I-MISC\nthe I-MISC\nLegend I-MISC\n\" O\nand O\nDuran B-PER\nstill O\ntalks O\nas O\nif O\nhe O\nwas O\nin O\nhis O\nprime O\n. O\n\n\" O\nI O\nwant O\na O\nfifth O\ntitle O\n. O\n\nThis O\nmatch O\nis O\nto O\nprepare O\nme O\n. O\n\nI O\nfeel O\ngood O\n. O\n\nI O\n'm O\nnot O\nretiring O\n, O\n\" O\nDuran B-PER\ntold O\nReuters B-ORG\n. O\n\nBut O\nthose O\nclose O\nto O\nthe O\nboxer O\nacknowledge O\nthat O\nthe O\nman O\nwho O\nhas O\nwon O\nchampionships O\nin O\nfour O\ndifferent O\nweight O\nclasses O\n-- O\nlightweight O\n, O\nwelterweight O\n, O\njunior O\nmiddleweight O\nand O\nmiddleweight O\n-- O\nis O\ndrawing O\nclose O\nto O\nthe O\nend O\nof O\nhis O\ncareer O\n. O\n\n\" O\nEach O\ntime O\nhe O\nfights O\n, O\nhe O\n's O\non O\nthe O\nlast O\nfrontier O\nof O\nhis O\ncareer O\n. O\n\nIf O\nhe O\nloses O\nSaturday O\n, O\nit O\ncould O\ndevalue O\nhis O\nposition O\nas O\none O\nof O\nthe O\nworld O\n's O\ngreat O\nboxers O\n, O\n\" O\nPanamanian B-MISC\nBoxing B-ORG\nAssociation I-ORG\nPresident O\nRamon B-PER\nManzanares I-PER\nsaid O\n. O\n\nDuran B-PER\n, O\nwhose O\n97-12 O\nrecord O\nspans O\nthree O\ndecades O\n, O\nhopes O\na O\nwin O\nin O\nthe O\n10-round O\nbout O\nwill O\nearn O\nhim O\na O\nrematch O\nagainst O\nPuerto B-LOC\nRico I-LOC\n's O\nHector B-PER\n\" I-PER\nMacho I-PER\n\" I-PER\nCamacho I-PER\n. O\n\nCamacho B-PER\ntook O\na O\ncontroversial O\npoints O\ndecision O\nagainst O\nthe O\nPanamanian B-MISC\nin O\nAtlantic B-LOC\nCity I-LOC\nin O\nJune O\nin O\na O\ntitle O\nfight O\n. O\n\n-DOCSTART- O\n\nSQUASH O\n- O\nHONG B-MISC\nKONG I-MISC\nOPEN I-MISC\nQUARTER-FINAL O\nRESULTS O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-30 O\n\nQuarter-final O\nresults O\nin O\nthe O\nHong B-MISC\nKong I-MISC\nOpen I-MISC\non O\nFriday O\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n1 O\n- O\nJansher B-PER\nKhan I-PER\n( O\nPakistan B-LOC\n) O\nbeat O\nMark B-PER\nCairns I-PER\n( O\nEngland B-LOC\n) O\n15-10 O\n15-6 O\n15-7 O\n\nAnthony B-PER\nHill I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nDan B-PER\nJenson I-PER\n( O\nAustralia B-LOC\n) O\n15-9 O\n15-8 O\n15-17 O\n17-15 O\n\n4 O\n- O\nPeter B-PER\nNicol I-PER\n( O\nScotland B-LOC\n) O\nbeat O\n7 O\n- O\nChris B-PER\nWalker I-PER\n( O\nEngland B-LOC\n) O\n15-8 O\n15-13 O\n13-15 O\n15-9 O\n\n2 O\n- O\nRodney B-PER\nEyles I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nDerek B-PER\nRyan I-PER\n( O\nIreland B-LOC\n) O\n15-6 O\n15-9 O\n11-15 O\n15-10 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nRESULTS O\nOF O\nSOUTH B-MISC\nKOREAN I-MISC\nPRO-SOCCER O\nGAMES O\n. O\n\nSEOUL B-LOC\n1996-08-30 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\npro-soccer O\n\ngames O\nplayed O\non O\nThursday O\n. O\n\nPohang B-ORG\n3 O\nUlsan B-ORG\n2 O\n( O\nhalftime O\n1-0 O\n) O\n\nPuchon B-ORG\n2 O\nChonbuk B-ORG\n1 O\n( O\nhalftime O\n1-1 O\n) O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nThursday O\n( O\ntabulate O\nunder O\n- O\n\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nW O\nD O\nL O\nG O\n/ O\nF O\nG O\n/ O\nA O\nP O\n\nPuchon B-ORG\n3 O\n1 O\n0 O\n6 O\n1 O\n10 O\n\nChonan B-ORG\n3 O\n0 O\n1 O\n13 O\n10 O\n9 O\n\nPohang B-ORG\n2 O\n1 O\n1 O\n11 O\n10 O\n7 O\n\nSuwan B-ORG\n1 O\n3 O\n0 O\n7 O\n3 O\n6 O\n\nUlsan B-ORG\n1 O\n0 O\n2 O\n8 O\n9 O\n3 O\n\nAnyang B-ORG\n0 O\n3 O\n1 O\n6 O\n9 O\n3 O\n\nChonnam B-ORG\n0 O\n2 O\n1 O\n4 O\n5 O\n2 O\n\nPusan B-ORG\n0 O\n2 O\n1 O\n3 O\n7 O\n2 O\n\nChonbuk B-ORG\n0 O\n0 O\n3 O\n3 O\n7 O\n0 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nRESULTS O\nOF O\nS. B-MISC\nKOREAN I-MISC\nPROFESSIONAL O\nGAMES O\n. O\n\nSEOUL B-LOC\n1996-08-30 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\n\nprofessional O\nbaseball O\ngames O\nplayed O\non O\nThursday O\n. O\n\nLG B-ORG\n2 O\nOB B-ORG\n0 O\n\nLotte B-ORG\n6 O\nHyundai B-ORG\n2 O\n\nHyundai B-ORG\n6 O\nLotte B-ORG\n5 O\n\nHaitai B-ORG\n2 O\nSamsung B-ORG\n0 O\n\nSamsung B-ORG\n10 O\nHaitai B-ORG\n3 O\n\nHanwha B-ORG\n6 O\nSsangbangwool B-ORG\n5 O\n\nNote O\n- O\nLotte B-ORG\nand O\nHyundai B-ORG\n, O\nHaitai B-ORG\nand O\nSamsung B-ORG\nplayed O\ntwo O\ngames O\n. O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nThursday O\n( O\ntabulate O\nunder O\n\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\nwinning O\npercentage O\n, O\ngames O\nbehind O\nfirst O\nplace O\n) O\n\nW O\nD O\nL O\nPCT O\nGB O\n\nHaitai B-ORG\n64 O\n2 O\n43 O\n.596 O\n- O\n\nSsangbangwool B-ORG\n59 O\n2 O\n49 O\n.545 O\n5 O\n1/2 O\n\nHanwha B-ORG\n58 O\n1 O\n49 O\n.542 O\n6 O\n\nHyundai B-ORG\n57 O\n5 O\n49 O\n.536 O\n6 O\n1/2 O\n\nSamsung B-ORG\n49 O\n5 O\n56 O\n.468 O\n14 O\n\nLotte B-ORG\n46 O\n6 O\n54 O\n.462 O\n14 O\n1/2 O\n\nLG B-ORG\n46 O\n5 O\n59 O\n.441 O\n17 O\n\nOB B-ORG\n42 O\n6 O\n62 O\n.409 O\n20 O\n1/2 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nFRIDAY O\n'S O\nRESULTS O\nFROM O\nTHE O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\nResults O\nfrom O\nthe O\nU.S. B-MISC\nOpen I-MISC\nTennis I-MISC\nChampionships I-MISC\nat O\nthe O\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\non O\nFriday O\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nWomen O\n's O\nsingles O\n, O\nthird O\nround O\n\nSandrine B-PER\nTestud I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nInes B-PER\nGorrochategui I-PER\n( O\nArgentina B-LOC\n) O\n4-6 O\n6-2 O\n6-1 O\n\nMen O\n's O\nsingles O\n, O\nsecond O\nround O\n\n4 O\n- O\nGoran B-PER\nIvanisevic I-PER\n( O\nCroatia B-LOC\n) O\nbeat O\nScott B-PER\nDraper I-PER\n( O\nAustralia B-LOC\n) O\n6-7 O\n( O\n1-7 O\n) O\n6-3 O\n6-4 O\n6-4 O\n\nTim B-PER\nHenman I-PER\n( O\nBritain B-LOC\n) O\nbeat O\nDoug B-PER\nFlach I-PER\n( O\nU.S. B-LOC\n) O\n6-3 O\n6-4 O\n6-2 O\n\nMark B-PER\nPhilippoussis I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nAndrei B-PER\nOlhovskiy I-PER\n( O\nRussia B-LOC\n) O\n6 O\n- O\n3 O\n6-4 O\n6-2 O\n\nSjeng B-PER\nSchalken I-PER\n( O\nNetherlands B-LOC\n) O\nbeat O\nDavid B-PER\nRikl I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n6 O\n- O\n2 O\n6-4 O\n6-4 O\n\nGuy B-PER\nForget I-PER\n( O\nFrance B-LOC\n) O\nbeat O\n17 O\n- O\nFelix B-PER\nMantilla I-PER\n( O\nSpain B-LOC\n) O\n6-4 O\n7-5 O\n6-3 O\n\nMen O\n's O\nsingles O\n, O\nsecond O\nround O\n\nAlexander B-PER\nVolkov I-PER\n( O\nRussia B-LOC\n) O\nbeat O\nMikael B-PER\nTillstrom I-PER\n( O\nSweden B-LOC\n) O\n1-6 O\n6- O\n4 O\n6-1 O\n4-6 O\n7-6 O\n( O\n10-8 O\n) O\n\nJonas B-PER\nBjorkman I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nDavid B-PER\nNainkin I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n) O\n6-4 O\n6-1 O\n6-1 O\n\nWomen O\n's O\nsingles O\n, O\nthird O\nround O\n\n8 O\n- O\nLindsay B-PER\nDavenport I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAnne-Gaelle B-PER\nSidot I-PER\n( O\nFrance B-LOC\n) O\n6-0 O\n6-3 O\n\n4 O\n- O\nConchita B-PER\nMartinez I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nHelena B-PER\nSukova I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n6-4 O\n6-3 O\n\nAmanda B-PER\nCoetzer I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\nIrina B-PER\nSpirlea I-PER\n( O\nRomania B-LOC\n) O\n7-6 O\n( O\n7-5 O\n) O\n7-5 O\n\nAdd O\nMen O\n's O\nsingles O\n, O\nsecond O\nround O\n16 O\n- O\nCedric B-PER\nPioline I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nRoberto B-PER\nCarretero I-PER\n( O\nSpain B-LOC\n) O\n4-6 O\n6 O\n- O\n2 O\n6-2 O\n6-1 O\nAlex B-PER\nCorretja I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nFilippo B-PER\nVeglio I-PER\n( O\nSwitzerland B-LOC\n) O\n6-7 O\n( O\n4- O\n7 O\n) O\n6-4 O\n6-4 O\n6-0 O\n\nAdd O\nWomen O\n's O\nsingles O\n, O\nthird O\nround O\nLinda B-PER\nWild I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nBarbara B-PER\nRittner I-PER\n( O\nGermany B-LOC\n) O\n6-4 O\n4-6 O\n7-5 O\nAsa B-PER\nCarlsson I-PER\n( O\nSweden B-LOC\n) O\nbeat O\n15 O\n- O\nGabriela B-PER\nSabatini I-PER\n( O\nArgentina B-LOC\n) O\n7-5 O\n3-6 O\n6-2 O\n\nAdd O\nMen O\n's O\nsingles O\n, O\nsecond O\nround O\n1 O\n- O\nPete B-PER\nSampras I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nJiri B-PER\nNovak I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n6-3 O\n1-6 O\n6-3 O\n4-6 O\n6-4 O\nPaul B-PER\nHaarhuis I-PER\n( O\nNetherlands B-LOC\n) O\nbeat O\nMichael B-PER\nTebbutt I-PER\n( O\nAustralia B-LOC\n) O\n1- O\n6 O\n6-2 O\n6-2 O\n6-3 O\n\nAdd O\nWomen O\n's O\nsingles O\n, O\nthird O\nround O\nLisa B-PER\nRaymond I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nKimberly B-PER\nPo I-PER\n( O\nU.S. B-LOC\n) O\n6-3 O\n6-2 O\n\n: O\n\nAdd O\nmen O\n's O\nsingles O\n, O\nsecond O\nround O\n\nHendrik B-PER\nDreekmann I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nThomas B-PER\nJohansson I-PER\n( O\nSweden B-LOC\n) O\n\n7-6 O\n( O\n7-1 O\n) O\n6-2 O\n4-6 O\n6-1 O\n\nAndrei B-PER\nMedvedev I-PER\n( O\nUkraine B-LOC\n) O\nbeat O\nJan B-PER\nKroslak I-PER\n( O\nSlovakia B-LOC\n) O\n6-4 O\n6-3 O\n\n6-2 O\n\nPetr B-PER\nKorda I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbat O\nBohdan B-PER\nUlihrach I-PER\n( O\nCzech B-LOC\n\nRepublic B-LOC\n) O\n6-0 O\n7-6 O\n( O\n7-5 O\n) O\n6-2 O\n\nAdd O\nwomen O\n's O\nsingles O\n, O\nthird O\nround O\n\n2 O\n- O\nMonica B-PER\nSeles I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nDally B-PER\nRandriantefy I-PER\n( O\nMadagascar B-LOC\n) O\n\n6-0 O\n6-2 O\n\n: O\n\nAdd O\nmen O\n's O\nsingles O\n, O\nsecond O\nround O\n12 O\n- O\nTodd B-PER\nMartin I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAndrea B-PER\nGaudenzi I-PER\n( O\nItaly B-LOC\n) O\n6-3 O\n6-2 O\n6-2 O\nStefan B-PER\nEdberg I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nBernd B-PER\nKarbacher I-PER\n( O\nGermany B-LOC\n) O\n3-6 O\n6-3 O\n6-3 O\n1-0 O\nretired O\n( O\nleg O\ninjury O\n) O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nTHURSDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nThursday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n74 O\n59 O\n.556 O\n- O\n\nBALTIMORE B-ORG\n70 O\n63 O\n.526 O\n4 O\n\nBOSTON B-ORG\n69 O\n65 O\n.515 O\n5 O\n1/2 O\n\nTORONTO B-ORG\n63 O\n71 O\n.470 O\n11 O\n1/2 O\n\nDETROIT B-ORG\n48 O\n86 O\n.358 O\n26 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n80 O\n53 O\n.602 O\n- O\n\nCHICAGO B-ORG\n71 O\n64 O\n.526 O\n10 O\n\nMINNESOTA B-ORG\n67 O\n67 O\n.500 O\n13 O\n1/2 O\n\nMILWAUKEE B-ORG\n64 O\n71 O\n.474 O\n17 O\n\nKANSAS B-ORG\nCITY I-ORG\n61 O\n74 O\n.452 O\n20 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n75 O\n58 O\n.564 O\n- O\n\nSEATTLE B-ORG\n70 O\n63 O\n.526 O\n5 O\n\nOAKLAND B-ORG\n64 O\n72 O\n.471 O\n12 O\n1/2 O\n\nCALIFORNIA B-ORG\n62 O\n72 O\n.463 O\n13 O\n1/2 O\n\nFRIDAY O\n, O\nAUGUST O\n30 O\nSCHEDULE O\n\nKANSAS B-ORG\nCITY I-ORG\nAT O\nDETROIT B-LOC\n\nCHICAGO B-ORG\nAT O\nTORONTO B-LOC\n\nMINNESOTA B-ORG\nAT O\nMILWAUKEE B-LOC\n\nCLEVELAND B-ORG\nAT O\nTEXAS B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nCALIFORNIA B-LOC\n\nBOSTON B-ORG\nAT O\nOAKLAND B-LOC\n\nBALTIMORE B-ORG\nAT O\nSEATTLE B-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n83 O\n49 O\n.629 O\n- O\n\nMONTREAL B-ORG\n71 O\n61 O\n.538 O\n12 O\n\nFLORIDA B-ORG\n64 O\n70 O\n.478 O\n20 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n75 O\n.440 O\n25 O\n\nPHILADELPHIA B-ORG\n54 O\n80 O\n.403 O\n30 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nHOUSTON B-ORG\n72 O\n63 O\n.533 O\n- O\n\nST B-ORG\nLOUIS I-ORG\n69 O\n65 O\n.515 O\n2 O\n1/2 O\n\nCINCINNATI B-ORG\n66 O\n67 O\n.496 O\n5 O\n\nCHICAGO B-ORG\n65 O\n66 O\n.496 O\n5 O\n\nPITTSBURGH B-ORG\n56 O\n77 O\n.421 O\n15 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n75 O\n60 O\n.556 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n72 O\n61 O\n.541 O\n2 O\n\nCOLORADO B-ORG\n70 O\n65 O\n.519 O\n5 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n57 O\n74 O\n.435 O\n16 O\n\nFRIDAY O\n, O\nAUGUST O\n30 O\nSCHEDULE O\n\nATLANTA B-ORG\nAT O\nCHICAGO B-LOC\n\nFLORIDA B-ORG\nAT O\nCINCINNATI B-LOC\n\nSAN B-ORG\nDIEGO I-ORG\nAT O\nMONTREAL B-LOC\n\nLOS B-ORG\nANGELES I-ORG\nAT O\nPHILADELPHIA B-LOC\n\nHOUSTON B-ORG\nAT O\nPITTSBURGH B-LOC\n\nSAN B-ORG\nFRANCISCO I-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nCOLORADO B-ORG\nAT O\nST B-LOC\nLOUIS I-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nTHURSDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\n\nBaseball O\ngames O\nplayed O\non O\nThursday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nAmerican B-MISC\nLeague I-MISC\n\nDETROIT B-ORG\n4 O\nKansas B-ORG\nCity I-ORG\n1 O\n\nMinnesota B-ORG\n6 O\nMILWAUKEE B-ORG\n1 O\n\nCALIFORNIA B-ORG\n14 O\nNew B-ORG\nYork I-ORG\n3 O\n\nSEATTLE B-ORG\n9 O\nBaltimore B-ORG\n6 O\n\nNational B-MISC\nLeague I-MISC\n\nSan B-ORG\nDiego I-ORG\n3 O\nNEW B-ORG\nYORK I-ORG\n2 O\n\nChicago B-ORG\n4 O\nHOUSTON B-ORG\n3 O\n\nCincinnati B-ORG\n18 O\nCOLORADO B-ORG\n7 O\n\nAtlanta B-ORG\n5 O\nPITTSBURGH B-ORG\n1 O\n\nLos B-ORG\nAngeles I-ORG\n2 O\nMONTREAL B-ORG\n1 O\n\nFlorida B-ORG\n10 O\nST B-ORG\nLOUIS I-ORG\n9 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nTARANGO B-PER\n, O\nO'BRIEN B-PER\nSPRING O\nTWIN O\nUPSETS O\nUNDER O\nTHE O\nLIGHTS O\n. O\n\nLarry B-PER\nFine I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\nAndre B-PER\nAgassi I-PER\nescaped O\ndisaster O\non O\nThursday O\nbut O\nWimbledon B-MISC\nfinalist O\nMaliVai B-PER\nWashington I-PER\nand O\nMarcelo B-PER\nRios I-PER\nwere O\nnot O\nso O\nfortunate O\non O\na O\nnight O\nof O\nupsets O\nat O\nthe O\nU.S. B-MISC\nOpen I-MISC\n. O\n\nThe O\n11th-seeded O\nWashington B-PER\nfell O\nshort O\nof O\nreprising O\nhis O\nWimbledon B-MISC\nmiracle O\ncomeback O\nas O\nhe O\nlost O\nto O\nred-hot O\nwildcard O\nAlex B-PER\nO'Brien I-PER\n6-3 O\n6-4 O\n5-7 O\n3-6 O\n6-3 O\nin O\na O\ntwo O\nhour O\n51 O\nminute O\nstruggle O\non O\nthe O\nStadium O\ncourt O\n. O\n\nNext O\ndoor O\non O\nthe O\ngrandstand O\n, O\n10th O\nseed O\nRios B-PER\nlost O\nto O\nanother O\nplayer O\nwith O\na O\nWimbledon B-MISC\nconnection O\n-- O\nbad O\nboy O\nJeff B-PER\nTarango I-PER\n. O\n\nThe O\ntemperamental O\nleft-hander O\ndefeated O\nthe O\nChilean B-MISC\n6-4 O\n4-6 O\n7-6 O\n6-2 O\n. O\n\nThe O\nday O\nprogramme O\nwent O\nsmoothly O\nalthough O\nsixth-seeded O\nformer O\nchampion O\nAgassi B-PER\nhad O\nto O\nwriggle O\nout O\nof O\na O\ndangerous O\n3-6 O\n0-4 O\nhole O\n, O\nwinning O\n18 O\nof O\nthe O\nlast O\n19 O\ngames O\nagainst O\nIndia B-LOC\n's O\nLeander B-PER\nPaes I-PER\n. O\n\nBut O\nthe O\nnight O\nbelonged O\nto O\nthe O\nupstarts O\n. O\n\nWashington B-PER\n, O\nwho O\nclimbed O\nback O\nfrom O\na O\n1-5 O\ndeficit O\n, O\ntwo O\nsets O\ndown O\nin O\nthe O\nthird O\nset O\nagainst O\nTodd B-PER\nMartin I-PER\nin O\nthe O\nWimbledon B-MISC\nsemifinals O\n, O\nlooked O\npoised O\nfor O\nanother O\nsensational O\ncomeback O\n. O\n\nO'Brien B-PER\n, O\na O\nwinner O\ntwo O\nweeks O\nago O\nin O\nNew B-LOC\nHaven I-LOC\nfor O\nhis O\nfirst O\npro O\ntitle O\n, O\nserved O\nfor O\nthe O\nmatch O\nat O\n5-4 O\nin O\nthe O\nthird O\nset O\nbefore O\nWashington B-PER\ncame O\ncharging O\nback O\n. O\n\n\" O\nI O\njust O\nkept O\nsaying O\nto O\nmyself O\n, O\n' O\nkeep O\ngiving O\nyourself O\nthe O\nbest O\nchance O\nto O\nwin O\n, O\nkeep O\nbattling O\n, O\nmaybe O\nsomething O\nwill O\nhappen O\n, O\n' O\n\" O\nsaid O\nthe O\n26-year-old O\nO'Brien B-PER\n, O\nranked O\n65th O\n. O\n\n\" O\nI O\nkept O\nmy O\ncomposure O\nand O\nI O\nwas O\nproud O\nof O\nmyself O\nfor O\nthat O\n-- O\nusually O\nI O\nwould O\nhave O\nfolded O\nup O\nthe O\ntent O\nand O\ngone O\nhome O\n. O\n\" O\n\nThe O\nhard-serving O\nO'Brien B-PER\n, O\na O\nformer O\nU.S. B-LOC\ncollegiate O\nnational O\nchampion O\n, O\nfired O\nup O\n17 O\naces O\nto O\nultimately O\nsubdue O\nthe O\nnever-say-die O\nWashington B-PER\n. O\n\nThe O\nfifth O\nset O\nstayed O\non O\nserve O\nuntil O\nthe O\nsixth O\ngame O\n, O\nwhen O\nWashington B-PER\n, O\nafter O\nsaving O\none O\nbreak O\npoint O\nwith O\na O\nforehand O\nwinner O\ndown O\nthe O\nline O\n, O\nnetted O\na O\nbackhand O\nto O\ngive O\nO'Brien B-PER\na O\n4-2 O\nlead O\n. O\n\nThe O\nTexan B-MISC\nblasted O\nin O\ntwo O\naces O\nto O\nhold O\nserve O\nat O\n5-2 O\nand O\nthen O\nconverted O\nhis O\neighth O\nmatch O\npoint O\nfor O\nvictory O\nwhen O\nWashington B-PER\nfound O\nthe O\nnet O\nwith O\nanother O\nbackhand O\nfrom O\n40-0 O\n. O\n\n\" O\nYou O\njust O\nkind O\nof O\nkeep O\nfighting O\nand O\nyou O\nkeep O\ntrying O\nto O\nmake O\nhim O\nplay O\na O\nlittle O\nbit O\n. O\n\nI O\nthink O\nhe O\ngot O\na O\nlittle O\ntight O\nat O\na O\ncouple O\nof O\nmoments O\n, O\n\" O\nsaid O\nWashington B-PER\n. O\n\" O\n\nBut O\nI O\nthink O\nhe O\nserved O\npretty O\nwell O\nwhen O\nhe O\nhad O\nto O\n. O\n\" O\n\nTarango B-PER\n, O\nwhose O\nWimbledon B-MISC\ntantrum O\ntwo O\nyears O\nago O\nbrought O\nhim O\na O\n$ O\n28,000 O\nfine O\nand O\nsuspension O\nfrom O\nthis O\nyear O\n's O\ntournament O\nat O\nthe O\nAll-England B-ORG\nClub I-ORG\n, O\nargued O\ncalls O\nand O\ntaunted O\nfans O\nin O\nhis O\nlively O\ntwo O\nhour O\n, O\n24 O\nminute O\ntango O\nwith O\nRios B-PER\non O\nthe O\ngrandstand O\n. O\n\nA O\nboisterous O\ncheering O\nsection O\nbacked O\nthe O\ndistracted O\nChilean B-MISC\nand O\nbooed O\nthe O\nlanky O\nAmerican B-MISC\n, O\nwho O\nate O\nup O\nall O\nthe O\nattention O\n. O\n\n\" O\nI O\n'm O\nan O\nemotional O\nplayer O\n, O\n\" O\nsaid O\nthe O\n104th-ranked O\nTarango B-PER\n. O\n\" O\n\nI O\nthink O\nI O\nplayed O\nvery O\nwell O\ntonight O\n, O\nvery O\nfocused O\n. O\n\" O\n\nThe O\nmatch O\nturned O\non O\nthe O\nthird-set O\ntiebreaker O\n, O\nwhich O\nthe O\nAmerican B-MISC\nwon O\n7-5 O\nmuch O\nto O\nthe O\ndismay O\nof O\nthe O\nspectators O\n. O\n\n\" O\nI O\nlove O\nthe O\ncrowd O\nif O\nthey O\nboo O\nme O\nevery O\nday O\n. O\n\nIt O\nfires O\nme O\nup O\n, O\nmakes O\nme O\nplay O\nmy O\nbest O\ntennis O\n, O\n\" O\nTarango B-PER\nsaid O\n. O\n\n\" O\nI O\nplayed O\nsome O\nof O\nmy O\nbest O\ntennis O\nin O\ncollege O\nwhen O\nfraternities O\nwere O\nthrowing O\nbeer O\non O\nme O\n. O\n\nIf O\ntennis O\nwas O\nlike O\nthat O\nevery O\nday O\n, O\nI O\nthink O\neverybody O\nwold O\nbe O\nhaving O\na O\nlot O\nmore O\nfun O\n. O\n\" O\n\nRios B-PER\ndid O\nnot O\nappreciate O\nTarango B-PER\n's O\nantics O\n. O\n\n\" O\nHe O\n's O\nalways O\ncomplaining O\ntoo O\nmuch O\n, O\n\" O\nsaid O\nRios B-PER\n. O\n\" O\n\nBut O\nI O\nthink O\nit O\n's O\nnot O\nthat O\n. O\n\nI O\nthink O\nI O\nplayed O\nreally O\nbad O\n. O\n\nIt O\nwas O\ntough O\nto O\nplay O\nat O\nnight O\n. O\n\nBalls O\nwere O\ngoing O\nreally O\nfast O\n. O\n\nI O\nlost O\ntoo O\nmany O\npoints O\nthat O\nI O\nnever O\nlose O\n. O\n\nI O\ndid O\nn't O\nplay O\nmy O\ntennis O\n. O\n\" O\n\n\" O\nI O\ndo O\nn't O\nsee O\nthe O\nball O\nlike O\nI O\nsee O\nduring O\nthe O\nday O\n. O\n\nI O\nplay O\nan O\nAmerican B-MISC\nso O\nthat O\n's O\nwhy O\nI O\nplay O\nat O\nnight O\n. O\n\nI O\ndid O\nn't O\nfeel O\ngood O\non O\nthe O\ncourt O\n. O\n\" O\n\nAt O\nthe O\nend O\nof O\nthe O\nmatch O\n, O\nTarango B-PER\nblew O\nsarcastic O\nkisses O\nto O\nthe O\ncrowd O\n, O\nthen O\njiggled O\nhis O\nbody O\nto O\na O\nRios B-PER\nrooting O\nsection O\nin O\na O\njeering O\nsalute O\n. O\n\n\" O\nI O\nsupport O\ntheir O\nenthusiasm O\n, O\n\" O\nTarango B-PER\nsaid O\nabout O\nthe O\nfans O\n. O\n\" O\n\nAt O\nthe O\nsame O\ntime O\n, O\nthey O\n're O\ncheering O\nblatantly O\nagainst O\nme O\n. O\n\nAfter O\nI O\nwon O\nI O\nfigured O\nI O\ncould O\ngive O\nthem O\na O\nlittle O\nrazzle-dazzle O\n. O\n\" O\n\n-DOCSTART- O\n\nNFL B-ORG\nAMERICAN B-MISC\nFOOTBALL-RANDALL I-MISC\nCUNNINGHAM B-PER\nRETIRES O\n. O\n\nPHILADELPHIA B-LOC\n1996-08-29 O\n\nRandall B-PER\nCunningham I-PER\n, O\nthe O\nNational B-ORG\nFootball I-ORG\nLeague I-ORG\n's O\nall-time O\nleading O\nrusher O\nas O\na O\nquarterback O\nand O\none O\nof O\nthe O\nmost O\nathletic O\nplayers O\never O\nto O\nline O\nup O\nover O\ncentre O\n, O\nretired O\nThursday O\n. O\n\nCunningham B-PER\nplayed O\nhis O\nentire O\n11-year O\ncareer O\nwith O\nthe O\nPhiladelphia B-ORG\nEagles I-ORG\n. O\n\nA O\nthree-time O\nPro B-MISC\nBowl I-MISC\nselection O\n, O\nCunningham B-PER\nrushed O\nfor O\n4,482 O\nyards O\non O\n677 O\ncarries O\n. O\n\n\" O\nI O\nwould O\nlike O\nto O\nthank O\nthe O\nEagles B-ORG\norganisation O\nand O\nthe O\nwonderful O\nfans O\nof O\nPhiladelphia B-ORG\nfor O\nsupporting O\nme O\nthroughout O\nmy O\ncareer O\n, O\n\" O\nCunningham B-PER\nsaid O\n. O\n\n\" O\nAlthough O\nit O\nsaddens O\nme O\nto O\nleave O\n, O\nI O\nam O\nlooking O\nforward O\nto O\nspending O\nmore O\ntime O\nwith O\nmy O\nfamily O\nand O\npursuing O\nother O\ninterests O\nthat O\nhave O\nbeen O\non O\nthe O\nback O\nburner O\nfor O\nsometime O\n. O\n\" O\n\n\" O\nRandall B-PER\nwas O\none O\nof O\nthe O\nmost O\nexciting O\nquarterbacks O\nin O\nNFL B-ORG\nhistory O\n, O\n\" O\nsaid O\nEagles B-ORG\nowner O\nJeffrey B-PER\nLurie I-PER\n. O\n\" O\n\nDuring O\nhis O\n11 O\nyears O\nin O\nPhiladelphia B-LOC\n, O\nRandall B-PER\nwas O\nthe O\ncornerstone O\nof O\nthe O\nEagles B-ORG\n' O\nfranchise O\nand O\nbrought O\nmany O\ngreat O\nmoments O\nto O\nfans O\nin O\nPhiladelphia B-LOC\nas O\nwell O\nas O\nacross O\nthe O\nNFL B-ORG\n. O\n\" O\n\nA O\nsecond-round O\nchoice O\nin O\n1985 O\n, O\nCunningham B-PER\ncompleted O\n1,874-of-3,362 O\npasses O\n( O\n55.7 O\npercent O\n) O\nfor O\n22,877 O\nyards O\nand O\n150 O\ntouchdowns O\n. O\n\nCunningham B-PER\nhas O\nalready O\nbeen O\nsigned O\nas O\na O\nbroadcaster O\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nLEADING O\nSCORES O\nAT O\nGREATER B-MISC\nMILWAUKEE I-MISC\nOPEN I-MISC\n. O\n\nMILWAUKEE B-LOC\n, O\nWisconsin B-LOC\n1996-08-29 O\n\nLeading O\nscores O\nin O\n\nthe O\n$ O\n1.2 O\nmillion O\nGreater B-MISC\nMilwaukee I-MISC\nOpen I-MISC\nat O\nthe O\npar-71 O\n, O\n\n6,739-yard O\nBrown B-LOC\nDeer I-LOC\nPark I-LOC\nGolf I-LOC\nCourse I-LOC\nafter O\nthe O\nfirst O\nround O\n\non O\nThursday O\n( O\nplayers O\nU.S. B-LOC\nunless O\nstated O\n) O\n: O\n\n62 O\nNolan B-PER\nHenke I-PER\n\n64 O\nBob B-PER\nEstes I-PER\n\n65 O\nBilly B-PER\nAndrade I-PER\n, O\nDuffy B-PER\nWaldorf I-PER\n, O\nJesper B-PER\nParnevik I-PER\n( O\nSweden B-LOC\n) O\n\n66 O\nNeal B-PER\nLancaster I-PER\n, O\nDave B-PER\nBarr I-PER\n( O\nCanada B-LOC\n) O\n, O\nMike B-PER\nSullivan I-PER\n, O\nWillie B-PER\n\nWood B-PER\n, O\nLoren B-PER\nRoberts I-PER\n, O\nSteve B-PER\nStricker I-PER\n, O\nBrian B-PER\nClaar I-PER\n, O\nRuss B-PER\nCochran I-PER\n\n67 O\nMark B-PER\nCalcavecchia I-PER\n, O\nPayne B-PER\nStewart I-PER\n, O\nBilly B-PER\nMayfair I-PER\n, O\nKen B-PER\n\nGreen B-PER\n, O\nJerry B-PER\nKelly I-PER\n, O\nTim B-PER\nSimpson I-PER\n, O\nOlin B-PER\nBrowne I-PER\n, O\nShane B-PER\nBortsch I-PER\n, O\n\nMike B-PER\nHulbert I-PER\n, O\nBrian B-PER\nHenninger I-PER\n, O\nTiger B-PER\nWoods I-PER\n, O\nSteve B-PER\nJurgenson I-PER\n, O\n\nBryan B-PER\nGorman I-PER\n\n-DOCSTART- O\n\nGOLF O\n- O\nHENKE B-PER\nTAKES O\nLEAD O\nIN O\nMILWAUKEE B-LOC\n, O\nWOODS B-PER\nMAKES O\nPRO O\nDEBUT O\n. O\n\nMILWAUKEE B-LOC\n, O\nWisconsin B-LOC\n1996-08-29 O\n\nNolan B-PER\nHenke I-PER\nfired O\na O\nnine-under-par O\n62 O\nto O\ngrab O\na O\ntwo-shot O\nlead O\nafter O\nthe O\nopening O\nround O\nof O\nthe O\n$ O\n1.2 O\nmillion O\nGreater B-MISC\nMilwaukee I-MISC\nOpen I-MISC\nThursday O\nas O\n20-year-old O\nTiger B-PER\nWoods I-PER\nshot O\n67 O\nin O\nhis O\nprofessional O\ndebut O\n. O\n\nHenke B-PER\nstood O\ntwo O\nstrokes O\nahead O\nof O\nBob B-PER\nEstes I-PER\nand O\nthree O\nup O\non O\nBilly B-PER\nAndrade I-PER\n, O\nDuffy B-PER\nWaldorf I-PER\nand O\nJesper B-PER\nParnevik I-PER\n. O\n\nWoods B-PER\n, O\nwho O\nturned O\npro O\nTuesday O\nafter O\nwinning O\nan O\nunprecedented O\nthird O\nsuccessive O\nU.S. B-MISC\nAmateur I-MISC\nChampionship I-MISC\n, O\nalmost O\neagled O\nthe O\n18th O\nhole O\n. O\n\nHe O\nsettled O\nfor O\na O\nbirdie O\nand O\na O\nfour-under O\nopening O\nround O\nthat O\nleft O\nhim O\nfive O\nshots O\noff O\nthe O\npace O\n. O\n\n\" O\nYesterday O\nwas O\nthe O\ntoughest O\nday O\nI O\n've O\nhad O\nfor O\na O\nlong O\ntime O\n, O\n\" O\nWoods B-PER\nsaid O\n. O\n\" O\n\nToday O\n, O\nI O\ngot O\nto O\nplay O\ngolf O\n. O\n\" O\n\nHe O\nadded O\n: O\n\" O\nI O\nthought O\nI O\ngot O\noff O\noff O\nto O\na O\ngreat O\nstart O\n. O\n\nIt O\nwas O\na O\nperfect O\nstart O\n. O\n\nI O\n'm O\nin O\na O\ngood O\nposition O\n. O\n\" O\n\nHenke B-PER\n, O\nwho O\ncalled O\nhis O\nround O\na O\n\" O\npleasant O\nsurprise O\n, O\n\" O\nfinished O\nwith O\nsix O\nbirdies O\non O\nthe O\nfinal O\neight O\nholes O\n. O\n\n\" O\nWe O\nfinally O\ngot O\nthings O\ngoing O\nin O\nthe O\nright O\ndirection O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nIt O\nwas O\nmy O\nbest O\nround O\nin O\na O\nvery O\nlong O\ntime O\n. O\n\nMy O\nshort O\ngame O\nhas O\nimproved O\nsince O\nI O\n've O\nhad O\nto O\nuse O\nit O\nso O\noften O\n. O\n\nThat O\n's O\nalways O\nbeen O\nthe O\nworst O\npart O\nof O\nmy O\ngame O\n. O\n\nAll O\nin O\nall O\n, O\nplaying O\nbad O\n's O\nbeen O\na O\ngood O\nexperience O\n. O\n\" O\n\nHenke B-PER\n, O\nwho O\ncame O\nwithin O\none O\nshot O\nof O\nthe O\ncourse O\nrecord O\nset O\nby O\nAndrew B-PER\nMagee I-PER\nduring O\nWednesday O\n's O\npro-am O\n, O\nhas O\nthree O\ncareer O\nPGA B-MISC\nTour I-MISC\nvictories O\n, O\nbut O\nnone O\nsince O\nthe O\n1993 O\nBellSouth B-MISC\nClassic I-MISC\n. O\n\nEstes B-PER\n, O\nwhose O\nonly O\nwin O\ncame O\nat O\nthe O\n1994 O\nTexas B-MISC\nOpen I-MISC\nand O\nwhose O\nbest O\nfinish O\nthis O\nyear O\nwas O\na O\nthird-place O\ntie O\nat O\nthe O\nNortel B-MISC\nOpen I-MISC\nin O\nJanuary O\n, O\neagled O\nthe O\npar-five O\nfourth O\nhole O\nand O\nadded O\nfive O\nbirdies O\nto O\ngrab O\nsole O\npossession O\nof O\nsecond O\nplace O\n. O\n\n\" O\nNo O\nbogeys O\non O\nthe O\ncard O\n, O\n\" O\nhe O\nnoted O\n. O\n\" O\n\nSometimes O\nI O\ntake O\nmore O\npride O\nin O\nthat O\n. O\n\" O\n\nWoods B-PER\nwas O\namong O\na O\ngroup O\nof O\n13 O\nplayers O\nat O\nfour O\nunder O\n, O\nincluding O\n1993 O\nchampion O\nBilly B-PER\nMayfair I-PER\n, O\nwho O\ntied O\nfor O\nsecond O\nat O\nlast O\nweek O\n's O\nWorld B-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\n, O\nand O\nformer O\nU.S. B-MISC\nOpen I-MISC\nchamp O\nPayne B-PER\nStewart I-PER\n. O\n\nDefending O\nchampion O\nScott B-PER\nHoch I-PER\nshot O\na O\nthree-under O\n68 O\nand O\nwas O\nsix O\nstrokes O\nback O\n. O\n\nPhil B-PER\nMickelson I-PER\n, O\nthe O\nonly O\nfour-time O\nwinner O\non O\nthe O\nPGA B-MISC\nTour I-MISC\n, O\nskipped O\nthe O\ntournament O\nafter O\nwinning O\nthe O\nWorld B-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\nlast O\nweek O\n. O\n\nMark B-PER\nBrooks I-PER\n, O\nTom B-PER\nLehman I-PER\nand O\nMark B-PER\nO'Meara I-PER\n, O\nwho O\nmake O\nup O\nthe O\nrest O\nof O\nthe O\ntop O\nfour O\non O\nthe O\nmoney O\nlist O\n, O\nalso O\ntook O\nthe O\nweek O\noff O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSILVA B-PER\n'S O\n`LOST O\nPASSPORT O\n' O\nEXCUSE O\nNOT O\nENOUGH O\nFOR O\nFIFA B-ORG\n. O\n\nMADRID B-LOC\n1996-08-30 O\n\nSpanish B-MISC\nfirst O\ndivision O\nteam O\nDeportivo B-ORG\nCoruna I-ORG\nwill O\nbe O\nwithout O\nkey O\nmidfielder O\nMauro B-PER\nSilva I-PER\nfor O\nSaturday O\n's O\ngame O\nwith O\nReal B-ORG\nMadrid I-ORG\nafter O\nFIFA B-ORG\n, O\nsoccer O\n's O\nworld O\ngoverning O\nbody O\n, O\nsuspended O\nthe O\nBrazilian B-MISC\nfor O\none O\ngame O\nfor O\nmissing O\nhis O\nnational O\nside O\n's O\nEuropean B-MISC\ntour O\n. O\n\nSilva B-PER\nexcused O\nhis O\nabsence O\nfrom O\nBrazil B-LOC\n's O\ngame O\nagainst O\nRussia B-LOC\n, O\non O\nWednesday O\n, O\nand O\nSaturday O\n's O\nmatch O\nwith O\nthe O\nNetherlands B-LOC\nby O\nsaying O\nhe O\nhad O\nlost O\nhis O\npassport O\n. O\n\nBut O\nthat O\ndid O\nnot O\nprevent O\nhim O\nfrom O\ncollecting O\nthe O\none-match O\nsuspension O\n. O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nMITCHELL B-PER\nDEFEATS O\nBAILEY B-PER\nIN O\nFRONT O\nOF O\nFORMER O\nCHAMPIONS O\n. O\n\nAdrian B-PER\nWarner I-PER\n\nBERLIN B-LOC\n1996-08-30 O\n\nAmerican B-MISC\nDennis B-PER\nMitchell I-PER\noutclassed O\nOlympic B-MISC\n100 O\nmetres O\nchampion O\nDonovan B-PER\nBailey I-PER\nfor O\nthe O\nthird O\ntime O\nat O\na O\nmajor O\npost-Games B-MISC\nmeeting O\nin O\nfront O\nof O\nthe O\nmost O\nexperienced O\nsprinting O\ncrowd O\nin O\nthe O\nworld O\non O\nFriday O\n. O\n\nWatched O\nby O\nan O\narray O\nof O\nformer O\nOlympic B-MISC\nsprint O\nchampions O\nat O\nthe O\nBerlin B-LOC\ngrand O\nprix O\nmeeting O\n, O\nMitchell B-PER\nmade O\na O\nbrilliant O\nstart O\nin O\nthe O\n100 O\nmetres O\nand O\nheld O\noff O\nBailey B-PER\n's O\nstrong O\nfinish O\nto O\nwin O\nin O\n10.08 O\nseconds O\ndespite O\ncool O\nconditions O\n. O\n\nBailey B-PER\n, O\nwho O\nset O\na O\nworld O\nrecord O\nof O\n9.84 O\non O\nhis O\nway O\nto O\nvictory O\nin O\nAtlanta B-LOC\n, O\ncould O\nnot O\ncatch O\nhis O\nAmerican B-MISC\nrival O\nand O\nhad O\nto O\nsettle O\nfor O\nthird O\nin O\na O\ntight O\nfinish O\n. O\n\nJamaica B-LOC\n's O\nMichael B-PER\nGreen I-PER\nwas O\nsecond O\nwith O\n10.09 O\nwith O\nBailey B-PER\nfinishing O\nin O\n10.13 O\n. O\n\nLast O\nFriday O\nMitchell B-PER\n, O\nwho O\nfinished O\nfourth O\nat O\nthe O\nAtlanta B-MISC\nGames I-MISC\n, O\nupstaged O\na O\ntrio O\nof O\nOlympic B-MISC\nchampions O\nincluding O\nBailey B-PER\nto O\nwin O\nthe O\n100 O\nin O\nBrussels B-LOC\n. O\n\nEarlier O\nthis O\nmonth O\nhe O\nalso O\nbeat O\nworld O\nchampion O\nBailey B-PER\nin O\nZurich B-LOC\n. O\n\nBerlin B-LOC\n, O\nBrussels B-LOC\nand O\nZurich B-LOC\nall O\nbelong O\nto O\nthe O\nmost O\nlucrative O\nseries O\nin O\nthe O\nsport O\n, O\nthe O\nGolden B-MISC\nFour I-MISC\n. O\n\nAmong O\nthe O\ncrowd O\non O\nFriday O\nwere O\nOlympic B-MISC\n100 O\nmetres O\nchampions O\ngoing O\nback O\nto O\n1948 O\n. O\n\nThey O\nhad O\nbeen O\ninvited O\nto O\nthe O\nmeeting O\nto O\nwatch O\na O\nspecial O\nrelay O\nto O\nmark O\nthe O\n60th O\nanniversary O\nof O\nJesse B-PER\nOwens I-PER\n's O\nfour O\ngold O\nmedals O\nat O\nthe O\n1936 O\nOlympics B-MISC\nin O\nthe O\nsame O\nBerlin B-LOC\nstadium O\n. O\n\n\" O\nToday O\nthe O\nconcentration O\nwas O\nthe O\nmost O\nimportant O\nthing O\nfor O\nme O\n, O\n\" O\nMitchell B-PER\nsaid O\n. O\n\nDespite O\nthe O\ncoolish O\nconditions O\nAmerican B-MISC\nOlympic I-MISC\nchampion O\nGail B-PER\nDevers I-PER\nlooked O\nin O\ncommanding O\nform O\nin O\nthe O\nwomen O\n's O\n100 O\n, O\nclocking O\n10.89 O\nto O\ndefeat O\nJamaican B-MISC\nrival O\nMerlene B-PER\nOttey I-PER\n, O\nwho O\nwas O\nsecond O\nin O\n10.94 O\n. O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nBERLIN B-MISC\nGRAND I-MISC\nPRIX I-MISC\nRESULTS O\n. O\n\nBERLIN B-LOC\n1996-08-30 O\n\nLeading O\nresults O\nat O\nthe O\nBerlin B-MISC\n\nGrand B-MISC\nPrix I-MISC\nathletics O\nmeeting O\non O\nFriday O\n: O\n\nWomen O\n's O\n100 O\nmetres O\nhurdles O\n\n1. O\nMichelle B-PER\nFreeman I-PER\n( O\nJamaica B-LOC\n) O\n12.71 O\nseconds O\n\n2. O\nLudmila B-PER\nEngquist I-PER\n( O\nSweden B-LOC\n) O\n12.74 O\n\n3. O\nAliuska B-PER\nLopez I-PER\n( O\nCuba B-LOC\n) O\n12.92 O\n\n4. O\nBrigita B-PER\nBokovec I-PER\n( O\nSlovenia B-LOC\n) O\n12.92 O\n\n5. O\nDionne B-PER\nRose I-PER\n( O\nJamaica B-LOC\n) O\n12.92 O\n\n6. O\nJulie B-PER\nBaumann I-PER\n( O\nSwitzerland B-LOC\n) O\n13.11 O\n\n7. O\nGillian B-PER\nRussell I-PER\n( O\nJamaica B-LOC\n) O\n13.17 O\n\nWomen O\n's O\n1,500 O\nmetres O\n\n1. O\nSvetlana B-PER\nMasterkova I-PER\n( O\nRussia B-LOC\n) O\nfour O\nminutes O\n6.87 O\nseconds O\n\n2. O\nPatricia B-PER\nDjate-Taillard I-PER\n( O\nFrance B-LOC\n) O\n4:08.22 O\n\n3. O\nCarla B-PER\nSacramento I-PER\n( O\nPortugal B-LOC\n) O\n4:08.96 O\n\n4. O\nYekaterina B-PER\nPodkopayeva I-PER\n( O\nRussia B-LOC\n) O\n4:09.25 O\n\n5. O\nLeah B-PER\nPells I-PER\n( O\nCanada B-LOC\n) O\n4:09.95 O\n\n6. O\nCarmen B-PER\nWuestenhagen I-PER\n( O\nGermany B-LOC\n) O\n4:10.38 O\n\n7. O\nMargarita B-PER\nMaruseva I-PER\n( O\nRussia B-LOC\n) O\n4:10.87 O\n\n8. O\nSara B-PER\nThorsett I-PER\n( O\nU.S. B-LOC\n) O\n4:11.06 O\n\nMen O\n's O\n110 O\nmetres O\nhurdles O\n\n1. O\nMark B-PER\nCrear I-PER\n( O\nU.S. B-LOC\n) O\n13.26 O\nseconds O\n\n2. O\nTony B-PER\nJarrett I-PER\n( O\nBritain B-LOC\n) O\n13.35 O\n\n3. O\nFlorian B-PER\nSchwarthoff I-PER\n( O\nGermany B-LOC\n) O\n13.36 O\n\n4. O\nEmilio B-PER\nValle I-PER\n( O\nCuba B-LOC\n) O\n13.52 O\n\n5. O\nFalk B-PER\nBalzer I-PER\n( O\nGermany B-LOC\n) O\n13.52 O\n\n6. O\nSteve B-PER\nBrown I-PER\n( O\nU.S. B-LOC\n) O\n13.53 O\n\n7. O\nFrank B-PER\nBusemann I-PER\n( O\nGermany B-LOC\n) O\n13.58 O\n\n8. O\nJack B-PER\nPierce I-PER\n( O\nU.S. B-LOC\n) O\n13.60 O\n\nMen O\n's O\n200 O\nmetres O\n\n1. O\nFrankie B-PER\nFredericks I-PER\n( O\nNamibia B-LOC\n) O\n19.97 O\nseconds O\n\n2. O\nMichael B-PER\nJohnson I-PER\n( O\nU.S. B-LOC\n) O\n20.02 O\n\n3. O\nAto B-PER\nBoldon I-PER\n( O\nTrinidad B-LOC\n) O\n20.37 O\n\n4. O\nGeir B-PER\nMoen I-PER\n( O\nNorway B-LOC\n) O\n20.41 O\n\n5. O\nPatrick B-PER\nStevens I-PER\n( O\nBelgium B-LOC\n) O\n20.54 O\n\n6. O\nJon B-PER\nDrummond I-PER\n( O\nU.S. B-LOC\n) O\n20.78 O\n\n7. O\nClaus B-PER\nHirsbro I-PER\n( O\nDenmark B-LOC\n) O\n20.90 O\n\n8. O\nIvan B-PER\nGarcia I-PER\n( O\nCuba B-LOC\n) O\n20.96 O\n\nWomen O\n's O\nshot O\nput O\n\n1. O\nAstrid B-PER\nKumbernuss I-PER\n( O\nGermany B-LOC\n) O\n19.89 O\nmetres O\n\n2. O\nClaudia B-PER\nMues I-PER\n( O\nGermany B-LOC\n) O\n18.80 O\n\n3. O\nIrina B-PER\nKorzhanenko I-PER\n( O\nRussia B-LOC\n) O\n18.63 O\n\n4. O\nValentina B-PER\nFedyushina I-PER\n( O\nRussia B-LOC\n) O\n18.55 O\n\n5. O\nStephanie B-PER\nStorp I-PER\n( O\nGermany B-LOC\n) O\n18.41 O\n\nMen O\n's O\nmile O\n\n1. O\nNoureddine B-PER\nMorceli I-PER\n( O\nAlgeria B-LOC\n) O\n3 O\nminutes O\n49.09 O\nseconds O\n\n2. O\nVenuste B-PER\nNiyongabo I-PER\n( O\nBurundi B-LOC\n) O\n3:51.01 O\n\n3. O\nWilliam B-PER\nTanui I-PER\n( O\nKenya B-LOC\n) O\n3:51.40 O\n\n4. O\nLaban B-PER\nRotich I-PER\n( O\nKenya B-LOC\n) O\n3:53.42 O\n\n5. O\nMarko B-PER\nKoers I-PER\n( O\nNetherlands B-LOC\n) O\n3:53.47 O\n\n6. O\nIsaac B-PER\nViciosa I-PER\n( O\nSpain B-LOC\n) O\n3:53.85 O\n\n7. O\nJohn B-PER\nMayock I-PER\n( O\nBritain B-LOC\n) O\n3:54.67 O\n\n8. O\nMarcus B-PER\nO'Sullivan I-PER\n( O\nIreland B-LOC\n) O\n3:54.87 O\n\nMen O\n's O\ndiscus O\n\n1. O\nLars B-PER\nRiedel I-PER\n( O\nGermany B-LOC\n) O\n70.60 O\nmetres O\n\n2. O\nAnthony B-PER\nWashington I-PER\n( O\nU.S. B-LOC\n) O\n68.44 O\n\n3. O\nVasily B-PER\nKaptyukh I-PER\n( O\nBelarus B-LOC\n) O\n66.24 O\n\n4. O\nVladimir B-PER\nDubrovshchik I-PER\n( O\nBelarus B-LOC\n) O\n65.30 O\n\n5. O\nVirgilijus B-PER\nAlekna I-PER\n( O\nLithuania B-LOC\n) O\n65.00 O\n\n6. O\nJuergen B-PER\nSchult I-PER\n( O\nGermany B-LOC\n) O\n64.46 O\n\n7. O\nAndreas B-PER\nSeelig I-PER\n( O\nGermany B-LOC\n) O\n62.00 O\n\n8. O\nMichael B-PER\nMoellenbeck I-PER\n( O\nGermany B-LOC\n) O\n58.56 O\n\nWomen O\n's O\n100 O\nmetres O\n\n1. O\nGail B-PER\nDevers I-PER\n( O\nU.S. B-LOC\n) O\n10.89 O\nseconds O\n\n2. O\nMerlene B-PER\nOttey I-PER\n( O\nJamaica B-LOC\n) O\n10.94 O\n\n3. O\nGwen B-PER\nTorrence I-PER\n( O\nU.S. B-LOC\n) O\n11.07 O\n\n4. O\nMary B-PER\nOnyali I-PER\n( O\nNigeria B-LOC\n) O\n11.14 O\n\n5. O\nChryste B-PER\nGaines I-PER\n( O\nU.S. B-LOC\n) O\n11.20 O\n\n6. O\nChandra B-PER\nSturrup I-PER\n( O\nBahamas B-LOC\n) O\n11.26 O\n\n7. O\nIrina B-PER\nPrivalova I-PER\n( O\nRussia B-LOC\n) O\n11.27 O\n\n8. O\nInger B-PER\nMiller I-PER\n( O\nU.S. B-LOC\n) O\n11.37 O\n\nWomen O\n's O\n5,000 O\nmetres O\n\n1. O\nGabriela B-PER\nSzabo I-PER\n( O\nRomania B-LOC\n) O\n15 O\nminutes O\n04.95 O\nseconds O\n\n2. O\nGete B-PER\nWami I-PER\n( O\nEthiopia B-LOC\n) O\n15:05.21 O\n\n3. O\nRose B-PER\nCheruiyot I-PER\n( O\nKenya B-LOC\n) O\n15:05.41 O\n\n4. O\nAnnemari B-PER\nSandell I-PER\n( O\nFinland B-LOC\n) O\n15:06.33 O\n\n5. O\nTegla B-PER\nLoroupe I-PER\n( O\nKenya B-LOC\n) O\n15:08.79 O\n\n6. O\nGunhild B-PER\nHalle I-PER\n( O\nNorway B-LOC\n) O\n15:09.00 O\n\n7. O\nPauline B-PER\nKonga I-PER\n( O\nKenya B-LOC\n) O\n15:09.74 O\n\n8. O\nSally B-PER\nBarsosio I-PER\n( O\nKenya B-LOC\n) O\n15:14.34 O\n\nMen O\n's O\n400 O\nmetres O\nhurdles O\n\n1. O\nTorrance B-PER\nZellner I-PER\n( O\nU.S. B-LOC\n) O\n48.23 O\nseconds O\n\n2. O\nSamuel B-PER\nMatete I-PER\n( O\nZambia B-LOC\n) O\n48.34 O\n\n3. O\nDerrick B-PER\nAdkins I-PER\n( O\nU.S. B-LOC\n) O\n48.62 O\n\n4. O\nFabrizio B-PER\nMori I-PER\n( O\nItaly B-LOC\n) O\n49.21 O\n\n5. O\nSven B-PER\nNylander I-PER\n( O\nSweden B-LOC\n) O\n49.22 O\n\n6. O\nEric B-PER\nThomas I-PER\n( O\nU.S. B-LOC\n) O\n49.35 O\n\n7. O\nRohan B-PER\nRobinson I-PER\n( O\nAustralia B-LOC\n) O\n49.36 O\n\n8. O\nDusan B-PER\nKovacs I-PER\n( O\nHungary B-LOC\n) O\n49.58 O\n\nWomen O\n's O\n400 O\nmetres O\n\n1. O\nFalilat B-PER\nOgunkoya I-PER\n( O\nNigeria B-LOC\n) O\n50.31 O\nseconds O\n\n2. O\nJearl B-PER\nMiles I-PER\n( O\nU.S. B-LOC\n) O\n50.42 O\n\n3. O\nFatima B-PER\nYusuf I-PER\n( O\nNigeria B-LOC\n) O\n51.43 O\n\n4. O\nAnja B-PER\nRuecker I-PER\n( O\nGermany B-LOC\n) O\n51.61 O\n\n5. O\nOlabisi B-PER\nAfolabi I-PER\n( O\nNigeria B-LOC\n) O\n51.98 O\n\n6. O\nPhylis B-PER\nSmith I-PER\n( O\nBritain B-LOC\n) O\n52.05 O\n\n7. O\nLinda B-PER\nKisabaka I-PER\n( O\nGermany B-LOC\n) O\n52.41 O\n\n8. O\nKarin B-PER\nJanke I-PER\n( O\nGermany B-LOC\n) O\n53.13 O\n\nMen O\n's O\n100 O\nmetres O\n\n1. O\nDennis B-PER\nMitchell I-PER\n( O\nU.S. B-LOC\n) O\n10.08 O\n\n2. O\nMichael B-PER\nGreen I-PER\n( O\nJamaica B-LOC\n) O\n10.09 O\n\n3. O\nDonovan B-PER\nBailey I-PER\n( O\nCanada B-LOC\n) O\n10.13 O\n\n4. O\nJon B-PER\nDrummond I-PER\n( O\nU.S. B-LOC\n) O\n10.22 O\n\n5. O\nDavidson B-PER\nEzinwa I-PER\n( O\nNigeria B-LOC\n) O\n10.24 O\n\n6. O\nGeir B-PER\nMoen I-PER\n( O\nNorway B-LOC\n) O\n10.33 O\n\n7. O\nMarc B-PER\nBlume I-PER\n( O\nGermany B-LOC\n) O\n10.48 O\n\nMen O\n's O\n800 O\nmetres O\n\n1. O\nWilson B-PER\nKipketer I-PER\n( O\nDenmark B-LOC\n) O\n1:43.34 O\n\n2. O\nNorberto B-PER\nTellez I-PER\n( O\nCuba B-LOC\n) O\n1:44.58 O\n\n3. O\nSammy B-PER\nLangat I-PER\n( O\nKenya B-LOC\n) O\n1:44.96 O\n\n4. O\nNico B-PER\nMotchebon I-PER\n( O\nGermany B-LOC\n) O\n1:45.03 O\n\n5. O\nDavid B-PER\nKiptoo I-PER\n( O\nKenya B-LOC\n) O\n1:45.27 O\n\n6. O\nAdem B-PER\nHacini I-PER\n( O\nAlgeria B-LOC\n) O\n1:45.64 O\n\n7. O\nVebjoen B-PER\nRodal I-PER\n( O\nNorway B-LOC\n) O\n1:46.45 O\n\n8. O\nCraig B-PER\nWinrow I-PER\n( O\nBritain B-LOC\n) O\n1:46.66 O\n\nMen O\n's O\npole O\nvault O\n\n1= O\nAndrei B-PER\nTiwontschik I-PER\n( O\nGermany B-LOC\n) O\n5.86 O\n\n1= O\nIgor B-PER\nTrandenkov I-PER\n( O\nRussia B-LOC\n) O\n5.86 O\n\n3. O\nMaksim B-PER\nTarasov I-PER\n( O\nRussia B-LOC\n) O\n5.86 O\n\n4. O\nTim B-PER\nLobinger I-PER\n( O\nGermany B-LOC\n) O\n5.80 O\n\n5. O\nIgor B-PER\nPotapovich I-PER\n( O\nKazakstan B-LOC\n) O\n5.80 O\n\n6. O\nJean B-PER\nGalfione I-PER\n( O\nFrance B-LOC\n) O\n5.65 O\n\n7. O\nPyotr B-PER\nBochkary I-PER\n( O\nRussia B-LOC\n) O\n5.65 O\n\n8. O\nDmitri B-PER\nMarkov I-PER\n( O\nBelarus B-LOC\n) O\n5.65 O\n\nWomen O\n's O\nhigh O\njump O\n\n1. O\nStefka B-PER\nKostadinova I-PER\n( O\nBulgaria B-LOC\n) O\n2.03 O\n\n2. O\nInga B-PER\nBabakova I-PER\n( O\nUkraine B-LOC\n) O\n2.00 O\nmetres O\n\n3. O\nAlina B-PER\nAstafei I-PER\n( O\nGermany B-LOC\n) O\n1.97 O\n\n4. O\nTatyana B-PER\nMotkova I-PER\n( O\nRussia B-LOC\n) O\n1.97 O\n\n5. O\nHanne B-PER\nHaugland I-PER\n( O\nNorway B-LOC\n) O\n1.91 O\n\n6= O\nNele B-PER\nZilinskiene I-PER\n( O\nLithuania B-LOC\n) O\n1.91 O\n\n6= O\nYelena B-PER\nGulyayeva I-PER\n( O\nRussia B-LOC\n) O\n1.91 O\n\n8. O\nNatalya B-PER\nGolodnova I-PER\n( O\nRussia B-LOC\n) O\n1.85 O\n\nMen O\n's O\n5,000 O\nmetres O\n\n1. O\nDaniel B-PER\nKomen I-PER\n( O\nKenya B-LOC\n) O\n13 O\nminutes O\n2.62 O\nseconds O\n\n2. O\nBob B-PER\nKennedy I-PER\n( O\nU.S. B-LOC\n) O\n13:06.12 O\n\n3. O\nPaul B-PER\nKoech I-PER\n( O\nKenya B-LOC\n) O\n13:06.45 O\n\n4. O\nEl B-PER\nHassane I-PER\nLahssini I-PER\n( O\nMorocco B-LOC\n) O\n13:06.57 O\n\n5. O\nShem B-PER\nKororia I-PER\n( O\nKenya B-LOC\n) O\n13:06.65 O\n\n6. O\nBrahim B-PER\nLahlafi I-PER\n( O\nMorocco B-LOC\n) O\n13:08.05 O\n\n7. O\nTom B-PER\nNyariki I-PER\n( O\nKenya B-LOC\n) O\n13:20.12 O\n\n8. O\nFita B-PER\nBayissa I-PER\n( O\nEthiopia B-LOC\n) O\n13:21.35 O\n\nMen O\n's O\ntriple O\njump O\n\n1. O\nJonathan B-PER\nEdwards I-PER\n( O\nBritain B-LOC\n) O\n17.69 O\nmetres O\n\n2. O\nYoelvis B-PER\nQuesada I-PER\n( O\nCuba B-LOC\n) O\n17.44 O\n\n3. O\nKenny B-PER\nHarrison I-PER\n( O\nU.S. B-LOC\n) O\n17.16 O\n\n4. O\nMike B-PER\nConley I-PER\n( O\nU.S. B-LOC\n) O\n16.79 O\n\n5. O\nArmen B-PER\nMartirosyan I-PER\n( O\nArmenia B-LOC\n) O\n16.57 O\n\n6. O\nSigurd B-PER\nNjerve I-PER\n( O\nNorway B-LOC\n) O\n16.41 O\n\n7. O\nCarlos B-PER\nCalado I-PER\n( O\nPortugal B-LOC\n) O\n16.31 O\n\n8. O\nCharles-Michael B-PER\nFriedek I-PER\n( O\nGermany B-LOC\n) O\n16.12 O\n\nWomen O\n's O\njavelin O\n\n1. O\nTanja B-PER\nDamaske I-PER\n( O\nGermany B-LOC\n) O\n66.60 O\nmetres O\n\n2. O\nTrine B-PER\nHattesta I-PER\n( O\nNorway B-LOC\n) O\n65.12 O\n\n3. O\nIsel B-PER\nLopez I-PER\n( O\nCuba B-LOC\n) O\n65.10 O\n\n4. O\nHeli B-PER\nRantanen I-PER\n( O\nFinland B-LOC\n) O\n62.78 O\n\n5. O\nLouise B-PER\nMcPaul I-PER\n( O\nAustralia B-LOC\n) O\n62.06 O\n\n6. O\nXiomara B-PER\nRivero I-PER\n( O\nCuba B-LOC\n) O\n61.94 O\n\n7. O\nNatalya B-PER\nShikolen I-PER\n( O\nBelarus B-LOC\n) O\n60.74 O\n\n8. O\nRita B-PER\nRamaunaskaite I-PER\n( O\nLithuania B-LOC\n) O\n60.74 O\n\nMen O\n's O\n4x100 O\nrelay O\nJesse B-PER\nOwens I-PER\nmemorial O\nrace O\n\n1. O\nDonovan B-PER\nBailey I-PER\n( O\nCanada B-LOC\n) O\n, O\nMichael B-PER\nJohnson I-PER\n( O\nU.S. B-LOC\n) O\n, O\nFrankie B-PER\n\nFredericks B-PER\n( O\nNamibia B-LOC\n) O\n, O\nLinford B-PER\nChristie I-PER\n( O\nBritain B-LOC\n) O\n38.87 O\nseconds O\n\n2. O\nMichael B-PER\nGreen I-PER\n( O\nJamaica B-LOC\n) O\n, O\nOsmond B-PER\nEzinwa I-PER\n( O\nNigeria B-LOC\n) O\n, O\nOeji B-PER\nAliu I-PER\n\n( O\nNigeria B-LOC\n) O\n, O\nDavidson B-PER\nEzinwa I-PER\n( O\nNigeria B-LOC\n) O\n38.87 O\n\n3. O\nPeter B-PER\nKarlsson I-PER\n( O\nSweden B-LOC\n) O\n, O\nFalk B-PER\nBalzer I-PER\n( O\nGermany B-LOC\n) O\n, O\nGeorge B-PER\n\nPanayiotopoulos B-PER\n( O\nGreece B-LOC\n) O\n, O\nFlorian B-PER\nSchwarthoff I-PER\n( O\nGermany B-LOC\n) O\n39.93 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nTHREE O\nSTANDARD B-ORG\nLIEGE I-ORG\nPLAYERS O\nBANNED O\n, O\nCLUB O\nFINED O\n. O\n\nGENEVA B-LOC\n1996-08-30 O\n\nUEFA B-ORG\ncame O\ndown O\nheavily O\non O\nBelgian B-MISC\nclub O\nStandard B-ORG\nLiege I-ORG\non O\nFriday O\nfor O\n\" O\ndisgraceful O\nbehaviour O\n\" O\nin O\nan O\nIntertoto B-MISC\nfinal O\nmatch O\nagainst O\nKarlsruhe B-ORG\nof O\nGermany B-LOC\n. O\n\nThe O\nBelgian B-MISC\nclub O\nwere O\nfined O\n25,000 O\nSwiss B-MISC\nfrancs O\n( O\n$ O\n20,850 O\n) O\nfor O\nunsporting O\nconduct O\nand O\ncaptain O\nGuy B-PER\nHellers I-PER\nbanned O\nfor O\nseven O\ngames O\n. O\n\nHe O\nwas O\nsent O\noff O\nfor O\ninsulting O\nthe O\nreferee O\nand O\nthen O\nurged O\nhis O\nteam O\nmates O\nto O\nprotest O\n. O\n\nRoberto B-PER\nBisconti I-PER\nwill O\nbe O\nsidelined O\nfor O\nsix O\nEuro B-MISC\nties O\nafter O\npushing O\nthe O\nreferee O\nin O\nthe O\nback O\nas O\nhe O\nprotested O\nabout O\na O\nKarlsruhe B-ORG\ngoal O\n, O\nwhile O\nDidier B-PER\nErnst I-PER\nwas O\nbanned O\nfor O\nfour O\nmatches O\nfor O\na O\nverbal O\nattack O\nsoon O\nafter O\nBisconti B-PER\nwas O\nalso O\ndismissed O\n. O\n\nKarlsruhe B-ORG\nwon O\nthe O\nAugust O\n20 O\nmatch O\n3-1 O\nthanks O\nto O\ntwo O\nlate O\ngoals O\n. O\n\nThey O\ntook O\nthe O\ntie O\n3-2 O\non O\naggregate O\nand O\nqualified O\nfor O\nthe O\nUEFA B-MISC\nCup I-MISC\n. O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nHARRISON B-PER\n, O\nEDWARDS B-PER\nTO O\nMEET O\nIN O\nSARAJEVO B-LOC\n. O\n\nMONTE B-LOC\nCARLO I-LOC\n1996-08-30 O\n\nOlympic B-MISC\nchampion O\nKenny B-PER\nHarrison I-PER\nand O\nworld O\nrecord O\nholder O\nJonathan B-PER\nEdwards I-PER\nwill O\nboth O\ntake O\npart O\nin O\na O\ntriple O\njump O\ncompetition O\nat O\nthe O\nSolidarity B-MISC\nMeeting I-MISC\nfor I-MISC\nSarajevo I-MISC\non O\nSeptember O\n9 O\n. O\n\nThe O\nInternational B-ORG\nAmateur I-ORG\nAthletic I-ORG\nFederation I-ORG\nsaid O\non O\nFriday O\nthat O\na O\nschedule O\nreshuffle O\nhad O\nallowed O\norganisers O\nto O\nhold O\na O\nmen O\n's O\ntriple O\njump O\nas O\nwell O\nas O\nthe O\nwomen O\n's O\nlong O\njump O\non O\nthe O\n\" O\none O\nusable O\nrunway O\nat O\nthe O\nwar-devastated O\n\" O\nKosevo B-LOC\nstadium O\n. O\n\nAtlanta B-MISC\nGames I-MISC\nsilver O\nmedal O\nwinner O\nEdwards B-PER\nhas O\ncalled O\non O\nother O\nleading O\nathletes O\nto O\ntake O\npart O\nin O\nthe O\nSarajevo B-LOC\nmeeting O\n-- O\na O\ngoodwill O\ngesture O\ntowards O\nBosnia B-LOC\nas O\nit O\nrecovers O\nfrom O\nthe O\nwar O\nin O\nthe O\nBalkans B-LOC\n-- O\ntwo O\ndays O\nafter O\nthe O\ngrand O\nprix O\nfinal O\nin O\nMilan B-LOC\n. O\n\nEdwards B-PER\nwas O\nquoted O\nas O\nsaying O\n: O\n\" O\nWhat O\ntype O\nof O\ncharacter O\ndo O\nwe O\nshow O\nby O\ngoing O\nto O\nthe O\nIAAF B-MISC\nGrand I-MISC\nPrix I-MISC\nFinal I-MISC\nin O\nMilan B-LOC\nwhere O\nthere O\nis O\na O\nlot O\nof O\nmoney O\nto O\nmake O\nbut O\nrefusing O\nto O\nmake O\nthe O\ntrip O\nto O\nSarajevo B-LOC\nas O\na O\nhumanitarian O\ngesture O\n? O\n\" O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBARATELLI B-PER\nTO O\nCOACH O\nNICE B-ORG\n. O\n\nNICE B-LOC\n, O\nFrance B-LOC\n1996-08-30 O\n\nFormer O\ninternational O\ngoalkeeper O\nDominique B-PER\nBaratelli I-PER\nis O\nto O\ncoach O\nstruggling O\nFrench B-MISC\nfirst O\ndivision O\nside O\nNice B-ORG\n, O\nthe O\nclub O\nsaid O\non O\nFriday O\n. O\n\nBaratelli B-PER\n, O\nwho O\nplayed O\nfor O\nNice B-ORG\nand O\nParis B-ORG\nSt I-ORG\nGermain I-ORG\n, O\ntakes O\nover O\nfrom O\nAlbert B-PER\nEmon I-PER\nwho O\nwas O\nfired O\non O\nThursday O\nafter O\nNice B-ORG\n's O\nhome O\ndefeat O\nto O\nGuingamp B-ORG\n2-1 O\nin O\nthe O\nleague O\n. O\n\nNice B-ORG\nhave O\nbeen O\nunable O\nto O\nwin O\nany O\nof O\ntheir O\nfour O\nleague O\nmatches O\nplayed O\nthis O\nseason O\nand O\nare O\nlying O\na O\nlowly O\n18th O\nin O\nthe O\ntable O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nMILAN B-ORG\n'S O\nLENTINI B-PER\nMOVES O\nTO O\nATALANTA B-ORG\n. O\n\nMILAN B-LOC\n1996-08-30 O\n\nFormer O\nItalian B-MISC\ninternational O\nwinger O\nGianluigi B-PER\nLentini I-PER\n, O\ntransferred O\nto O\nMilan B-ORG\nin O\n1992 O\nfor O\nwhat O\nwas O\nbelieved O\nto O\nbe O\na O\nworld O\nrecord O\nsum O\n, O\nhas O\nbeen O\nloaned O\nto O\nserie B-MISC\nA I-MISC\nclub O\nAtalanta B-ORG\nfor O\na O\nyear O\n, O\nnewspapers O\nreported O\non O\nFriday O\n. O\n\nThe O\nGazzetta B-ORG\ndello I-ORG\nSport I-ORG\nsaid O\nthe O\ndeal O\nwould O\ncost O\nAtalanta B-ORG\naround O\n$ O\n600,000 O\n. O\n\nLentini B-PER\n, O\n27 O\n, O\njoined O\nMilan B-ORG\nfrom O\nTorino B-ORG\nin O\na O\n$ O\n12 O\nmillion O\ndeal O\nthat O\nmany O\nhave O\nspeculated O\ninvolved O\nfar O\nmore O\nmoney O\nchanging O\nhands O\nand O\nwhich O\nhas O\nsubsequently O\nbeen O\ninvestigated O\nby O\nmagistrates O\nfor O\nalleged O\nfinancial O\nirregularities O\n. O\n\nThe O\nplayer O\nsuffered O\nsevere O\nhead O\ninjuries O\nin O\na O\nnear-fatal O\ncar O\ncrash O\nthe O\nfollowing O\nyear O\nand O\nhas O\nsince O\nstruggled O\nto O\nregain O\nthe O\nform O\nthat O\nmade O\nhim O\na O\nhero O\nin O\nTurin B-LOC\n. O\n\nThe O\nmove O\nto O\nBergamo-based B-MISC\nAtalanta B-ORG\nreunites O\nLentini B-PER\n, O\nwho O\nfell O\nout O\nwith O\nex-Milan B-MISC\ncoach O\nFabio B-PER\nCapello I-PER\nlast O\nseason O\n, O\nwith O\nhis O\nformer O\ncoach O\nat O\nTorino B-ORG\n, O\nEmiliano B-PER\nMondonico I-PER\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nSRI B-LOC\nLANKA I-LOC\nBEAT O\nAUSTRALIA B-LOC\nBY O\nFOUR O\nWICKETS O\n. O\n\nCOLOMBO B-LOC\n1996-08-30 O\n\nSri B-LOC\nLanka I-LOC\nbeat O\nAustralia B-LOC\nby O\nfour O\nwickets O\nin O\nthe O\nthird O\nmatch O\nof O\nthe O\nSinger B-MISC\nWorld I-MISC\nSeries I-MISC\none-day O\n( O\n50 O\novers O\n) O\ncricket O\ntournament O\non O\nFriday O\n. O\n\nScores O\n: O\nAustralia B-LOC\n228-9 O\nin O\n50 O\novers O\n, O\nSri B-LOC\nLanka I-LOC\n232-6 O\nin O\n45.5 O\novers O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nAUSTRALIA B-LOC\nV O\nSRI B-LOC\nLANKA I-LOC\nSCOREBOARD O\n. O\n\nCOLOMBO B-LOC\n1996-08-30 O\n\nScoreboard O\nof O\nthe O\nthird O\nSinger B-MISC\n\nWorld B-MISC\nSeries I-MISC\ncricket O\nmatch O\nbetween O\nAustralia B-LOC\nand O\nSri B-LOC\nLanka I-LOC\non O\n\nFriday O\n: O\n\nAustralia B-LOC\n\nM. B-PER\nWaugh I-PER\nc O\nand O\nb O\nJayasuriya B-PER\n50 O\n\nM. B-PER\nSlater I-PER\nrun O\nout O\n9 O\n\nS. B-PER\nLaw I-PER\nc O\nTillekeratne B-PER\nb O\nDharmasena B-PER\n13 O\n\nM. B-PER\nBevan I-PER\nc O\nVaas B-PER\nb O\nChandana B-PER\n56 O\n\nS. B-PER\nWaugh I-PER\nb O\nMuralitharan B-PER\n22 O\n\nR. B-PER\nPonting I-PER\nnot O\nout O\n46 O\n\nD. B-PER\nLehmann I-PER\nst O\nKaluwitharana B-PER\nb O\nChandana B-PER\n2 O\n\nI. B-PER\nHealy I-PER\nc O\nRanatunga B-PER\nb O\nMuralitharan B-PER\n8 O\n\nJ. B-PER\nGillespie I-PER\nst O\nKaluwitharana B-PER\nb O\nChandana B-PER\n6 O\n\nD. B-PER\nFleming I-PER\nc O\nChandana B-PER\nb O\nJayasuriya B-PER\n3 O\n\nG. B-PER\nMcGrath I-PER\nnot O\nout O\n8 O\n\nExtras O\n( O\nlb-3 O\nnb-2 O\n) O\n5 O\n\nTotal O\n( O\nnine O\nwickets O\n, O\n50 O\novers O\n) O\n228 O\n\nFall O\nof O\nwickets O\n: O\n1-21 O\n2-52 O\n3-97 O\n4-149 O\n5-157 O\n6-163 O\n7-178 O\n\n8-198 O\n9-203 O\n. O\n\nBowling O\n: O\nVass B-PER\n7-0-29-0 O\n, O\nde B-PER\nSilva I-PER\n4-0-25-0 O\n, O\nDharmasena B-PER\n\n9-0-49-1 O\n, O\nMuralitharan B-PER\n10-0-41-2 O\n, O\nJayasuriya B-PER\n10-0-43-2 O\n, O\nChandana B-PER\n\n10-0-38-3 O\n. O\n\nSri B-LOC\nLanka I-LOC\n\nS. B-PER\nJayasuriya I-PER\nc O\nHealy B-PER\nb O\nFleming B-PER\n44 O\n\nR. B-PER\nKaluwitharana I-PER\nb O\nS. B-PER\nWaugh I-PER\n8 O\n\nA. B-PER\nGurusinha I-PER\nrun O\nout O\n16 O\n\nA.de B-PER\nSilva I-PER\nnot O\nout O\n83 O\n\nA. B-PER\nRanatunga I-PER\nlbw O\nb O\nFleming B-PER\n0 O\n\nH. B-PER\nTillekeratne I-PER\nlbw O\nb O\nFleming B-PER\n1 O\n\nR. B-PER\nMahanama I-PER\nb O\nMcGrath B-PER\n50 O\n\nU. B-PER\nChandana I-PER\nnot O\nout O\n14 O\n\nExtras O\n( O\nlb-3 O\nnb-6 O\nw-7 O\n) O\n16 O\n\nTotal O\n( O\nsix O\nwickets O\n, O\n45.5 O\novers O\n) O\n232 O\n\nFall O\nof O\nwickets O\n: O\n1-22 O\n2-78 O\n3-78 O\n4-78 O\n5-81 O\n6-196 O\n. O\n\nDid O\nnot O\nbat O\n: O\nDharmasena B-PER\n, O\nVaas B-PER\n, O\nMuralitharan B-PER\n. O\n\nBowling O\n: O\nS. B-PER\nWaugh I-PER\n5-1-36-1 O\n, O\nLaw B-PER\n2-0-23-0 O\n, O\nMcGrath B-PER\n9.5-0-44-1 O\n, O\n\nFleming B-PER\n8-1-26-3 O\n, O\nGillespie B-PER\n6-0-27-0 O\n, O\nM. B-PER\nWaugh I-PER\n5-0-29-0 O\n, O\nLehmann B-PER\n\n6-0-26-0 O\n, O\nBevan B-PER\n4-0-18-0 O\n. O\n\nMan O\nof O\nthe O\nMatch O\n: O\nAravinda B-PER\nde I-PER\nSilva I-PER\n\nNext O\nSeries O\nmatch O\n: O\nIndia B-LOC\nv O\nZimbabwe B-LOC\n, O\nSeptember O\n1 O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nAUSTRALIA B-LOC\n228-9 O\nIN O\n50 O\nOVERS O\nV O\nSRI B-LOC\nLANKA I-LOC\n. O\n\nCOLOMBO B-LOC\n1996-08-30 O\n\nAustralia B-LOC\nscored O\n228 O\nfor O\nnine O\nwickets O\nin O\ntheir O\n50 O\novers O\nagainst O\nSri B-LOC\nLanka I-LOC\nin O\nthe O\nthird O\nday-night O\nlimited O\novers O\nmatch O\nof O\nthe O\nSinger B-MISC\nWorld I-MISC\nSeries I-MISC\ntournament O\non O\nFriday O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nAUSTRALIA B-LOC\nWIN O\nTOSS O\nAND O\nCHOOSE O\nTO O\nBAT O\n. O\n\nCOLOMBO B-LOC\n1996-08-30 O\n\nAustralia B-LOC\nwon O\nthe O\ntoss O\nand O\n\nelected O\nto O\nbat O\nagainst O\nSri B-LOC\nLanka I-LOC\nin O\nthe O\nthird O\nday-night O\nlimited O\n\novers O\ncricket O\nmatch O\nin O\nthe O\nSinger B-MISC\nworld O\nseries O\ntournament O\non O\n\nFriday O\n. O\n\nTeams O\n: O\n\nAustralia B-LOC\n- O\nIan B-PER\nHealy I-PER\n( O\ncaptain O\n) O\n, O\nMichael B-PER\nBevan I-PER\n, O\nDamien B-PER\n\nFlemming B-PER\n, O\nJason B-PER\nGillespie I-PER\n, O\nStuart B-PER\nLaw I-PER\n, O\nGlenn B-PER\nMcGrath I-PER\n, O\nRicky B-PER\n\nPonting B-PER\n, O\nMichael B-PER\nSlater I-PER\n, O\nDarren B-PER\nLehmann I-PER\n, O\nMark B-PER\nWaugh I-PER\n, O\nSteve B-PER\n\nWaugh B-PER\n. O\n\nSri B-LOC\nLanka I-LOC\n- O\nArjuna B-PER\nRanatunga I-PER\n( O\ncaptain O\n) O\n, O\nSanath B-PER\nJayasuriya I-PER\n, O\n\nRomesh B-PER\nKaluwitharana I-PER\n, O\nAsanka B-PER\nGurusinha I-PER\n, O\nAravinda B-PER\nde I-PER\nSilva I-PER\n, O\n\nHashan B-PER\nTillekeratne I-PER\n, O\nRoshan B-PER\nMahanama I-PER\n, O\nKumara B-PER\nDharmasena I-PER\n, O\n\nChaminda B-PER\nVaas I-PER\n, O\nMuthiah B-PER\nMuralitharan I-PER\n, O\nUpul B-PER\nChandana I-PER\n. O\n\n-DOCSTART- O\n\nROMANIA B-LOC\nCOMELF B-ORG\nH1 O\nPROFIT O\nRISE O\nBELOW O\nTARGET O\n. O\n\nBUCHAREST B-LOC\n1996-08-30 O\n\nRomanian B-MISC\nlisted O\nstate O\nengineer O\nComelf B-ORG\nsaid O\nit O\nalmost O\ndoubled O\nsix-month O\noutput O\n, O\nwith O\nnet O\nprofit O\nrising O\nby O\n33 O\npercent O\nto O\n1.069 O\nbillion O\nlei O\n. O\n\nBut O\nthe O\ncompany O\ncomplained O\ninflation O\nand O\nthe O\nartificially O\nhigh O\nrate O\nof O\nthe O\nleu O\ncut O\nprofit O\nmargins O\non O\nexports O\n, O\nkeeping O\nprofits O\nwell O\nbelow O\nits O\nforecast O\nof O\n1.4 O\nbillion O\nlei O\n. O\n\nComelf B-ORG\n's O\nsix-month O\noutput O\nrose O\nto O\n4,378 O\ntonnes O\nof O\nequipment O\nfrom O\n2,684 O\ntonnes O\nin O\nthe O\nequivalent O\nperiod O\nin O\n1995 O\n, O\nthe O\ncompany O\nreport O\nto O\nthe O\nBucharest B-LOC\nstock O\nexchange O\nshowed O\n. O\n\nComelf B-ORG\n, O\nbased O\nin O\nthe O\ncentral O\nTransylvanian B-MISC\ntown O\nof O\nBistrita B-LOC\n, O\nmanufactures O\nwater O\npurification O\nequipment O\n, O\nmachinery O\nfor O\nthe O\nthermal O\npower O\nsector O\nand O\nother O\nequipment O\n. O\n\n\" O\nIn O\nthe O\nfirst O\nsix O\nmonths O\nof O\n1996 O\nwe O\nconcentrated O\non O\nincreasing O\nthe O\nvolume O\nof O\nour O\noutput O\nand O\nexports O\nin O\nparticular O\nand O\nimproving O\nthe O\nquality O\nof O\nour O\nproducts O\n, O\n\" O\nthe O\nreport O\nsaid O\n. O\n\nFrom O\nJanuary O\nto O\nJune O\nComelf B-ORG\nexported O\n59 O\npercent O\nof O\nits O\noutput O\n, O\nup O\nfrom O\n37.3 O\npercent O\nin O\nthe O\nsame O\nperiod O\nlast O\nyear O\n. O\n\nThe O\ncompany O\nsaid O\nhigher O\nthan O\nanticipated O\ninflation O\nand O\nrising O\nraw O\nmaterials O\nand O\nwage O\ncosts O\nalso O\nhit O\nprofits O\n. O\n\nYear-on-year O\ninflation O\n, O\ninitially O\nestimated O\nat O\n20 O\npercent O\nin O\nDecember O\n, O\nwas O\n33.8 O\npercent O\nin O\nJune O\n, O\nhigher O\nthan O\na O\nrevised O\nend-year O\nforecast O\nof O\n30 O\npercent O\n. O\n\nThe O\n12 O\nmonth O\nfigure O\nquickened O\nto O\n40.3 O\npercent O\nin O\nJuly O\n. O\n\nThe O\nleu O\ncurrency O\nhas O\nslipped O\nonly O\ngradually O\nthis O\nyear O\n, O\nand O\nis O\ncurrently O\nquoted O\nat O\nan O\nofficial O\nrate O\nof O\n3,162 O\nto O\nthe O\ndollar O\n, O\nwell O\nbelow O\nthe O\n3,550 O\nretail O\nprice O\nthat O\nexporters O\nsay O\nis O\nmore O\nrealistic O\n. O\n\n-- O\nLuli B-PER\nPopescu I-PER\n, O\nBucharest B-ORG\nNewsroom I-ORG\n40-1 O\n3120264 O\n\n-DOCSTART- O\n\nPOLISH B-MISC\nNBP O\nREFRAINS O\nFROM O\nREVERSE O\nREPO O\nOPERATION O\n. O\n\nWARSAW B-LOC\n1996-08-30 O\n\nThe O\nNational B-ORG\nBank I-ORG\nof I-ORG\nPoland I-ORG\n\nrefrained O\nfrom O\nstaging O\na O\nreverse O\nrepo O\noperation O\non O\nFriday O\n, O\nthe O\n\nbank O\nsaid O\n. O\n\n-- O\nWarsaw B-ORG\nNewsroom I-ORG\n+48 O\n22 O\n653 O\n9700 O\n\n-DOCSTART- O\n\nCanada B-LOC\ngovernment O\ncash O\nbalances O\nfall O\nin O\nweek O\n. O\n\nOTTAWA B-LOC\n1996-08-30 O\n\nThe O\ngovernment O\nof O\nCanada B-LOC\n's O\ncash O\nbalances O\nfell O\nin O\nthe O\nweek O\nthat O\nended O\nAugust O\n28 O\n, O\nthe O\nBank B-ORG\nof I-ORG\nCanada I-ORG\nsaid O\non O\nFriday O\n. O\n\nWk O\nto O\nAug O\n28 O\nChg O\non O\nwk O\nChg O\non O\nyr O\n\nNotes O\nin O\ncirculation O\n27.35 O\n+0.435 O\n+0.237 O\n\nGovernment O\ncash O\nbalances O\n3.54 O\n- O\n0.629 O\n+0.089 O\n\nGovt O\nsecurities O\noutstanding O\n463.73 O\n+1.660 O\n+10.436 O\n\nTreasury B-ORG\nbills O\n152.80 O\n+0.300 O\n- O\n11.900 O\n\nCanada B-LOC\nsavings O\nbonds O\n30.12 O\n- O\n0.004 O\n+0.578 O\n\nAll O\nfigures O\nin O\nbillions O\nof O\ndollars O\n. O\n\nChartered O\nbank O\nassets O\nJuly O\nJune O\n\nNet O\nforeign O\ncurrency O\n- O\n12.63 O\n- O\n12.08 O\n\nCanadian B-MISC\ndollar O\n639.55 O\n639.38 O\n\nTotal O\nCanadian B-MISC\nliquid O\nassets O\n107.83 O\n107.24 O\n\nJuly O\n96 O\nJune O\n96 O\nJuly O\n95 O\n\nM1 O\n63.02 O\n62.83 O\n57.50 O\n\nM2 O\n389.79 O\n391.32 O\n381.65 O\n\nM3 O\n482.13 O\n480.72 O\n461.42 O\n\nNote O\n- O\nFigures O\nare O\nunadjusted O\n, O\nin O\nbillions O\nof O\ndollars O\n. O\n\n-- O\nReuters B-ORG\nOttawa I-ORG\nBureau I-ORG\n( O\n613 O\n) O\n235-6745 O\n\n-DOCSTART- O\n\nJones B-ORG\nMedical I-ORG\ncompletes O\nacquisition O\n. O\n\nST. B-LOC\nLOUIS I-LOC\n1996-08-30 O\n\nJones B-ORG\nMedical I-ORG\nIndustries I-ORG\nInc I-ORG\nsaid O\nFriday O\nit O\ncompleted O\nthe O\nacquisition O\nof O\nDaniels B-ORG\nPharmaceuticals I-ORG\nInc I-ORG\nof O\nSt. B-LOC\nPetersburg I-LOC\n, O\nFla. B-LOC\n, O\nfor O\nabout O\n2,960,000 O\nshares O\nof O\nJones B-ORG\ncommon O\nstock O\n. O\n\nJones B-ORG\nstock O\nclosed O\ndown O\n1/8 O\nat O\n40 O\nFriday O\n. O\n\nDaniels B-ORG\nPharmaceuticals I-ORG\nmanufactures O\nprescription O\npharmaceutical O\nproducts O\n, O\nthe O\nlargest O\nof O\nwhich O\nis O\nLevoxyl B-MISC\n, O\na O\nsynthetic O\nthyroid O\nhormone O\nfor O\ntreating O\nhypothyroidism O\n. O\n\n-- O\nChicago B-LOC\nnewsdesk O\n, O\n312 O\n408-8787 O\n\n-DOCSTART- O\n\nNYMEX O\nheating O\noil O\nnear O\nsession O\nlows O\nin O\npre-close O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\nNYMEX O\nrefined O\nproduct O\nprices O\nlingered O\nat O\nsession O\nlows O\namid O\nslim O\nvolume O\nbefore O\nthe O\nclose O\nwhile O\ncrude O\nexperienced O\nlackluster O\nbuying O\nahead O\nof O\nthe O\nU.S. B-LOC\nLabor B-MISC\nDay I-MISC\nweekend O\n, O\ntraders O\nsaid O\n. O\n\n\" O\nThere O\nwas O\nsome O\nprofit-taking O\nearly O\non O\n, O\nand O\nit O\n's O\njust O\nsitting O\nthere O\n, O\n\" O\na O\nTexas B-LOC\ntrader O\nsaid O\nof O\nheating O\noil O\n's O\nand O\ngasoline O\n's O\nlosses O\n. O\n\nSeptember O\nheating O\noil O\nstood O\n1.02 O\ncents O\nlower O\nat O\n62.65 O\ncents O\na O\ngallon O\n. O\n\nHeat O\nhit O\na O\nsession O\nlow O\nof O\n62.45 O\nshortly O\nbefore O\nthe O\nclose O\n. O\n\nSeptember O\ngasoline O\nstood O\n0.87 O\ncent O\nlower O\nat O\n62.85 O\ncents O\na O\ngallon O\n. O\n\nFriday O\n's O\nlow O\nin O\nSeptember O\ngasoline O\nwas O\n62.75 O\n. O\n\nTraders O\nalso O\nsaid O\nplayers O\nwere O\nselling O\nrefined O\nproducts O\nin O\nfavor O\nof O\ncrude O\nahead O\nof O\nthe O\nfront O\nmonth O\n's O\nFriday O\nexpiry O\nin O\nthe O\nrefined O\nproducts O\n. O\n\nThe O\nOctober O\nheating O\noil-to-crude O\ncrack O\nspread O\nnarrowed O\nto O\n$ O\n4.22 O\na O\nbarrel O\nfrom O\nThursday O\n's O\n$ O\n4.58 O\nwhile O\nthe O\nOctober O\ngasoline-to-crude O\nspread O\nnarrowed O\nto O\n$ O\n3.60 O\nfrom O\nThursday O\n's O\n$ O\n3.86 O\na O\nbarrel O\n. O\n\nOctober O\ncrude O\nstood O\neight O\ncents O\nhigher O\nat O\n$ O\n22.23 O\nbarrel O\n. O\n\nBuying O\ninterest O\nin O\ncrude O\ndid O\nnot O\nhave O\nenough O\nconviction O\nto O\nsend O\nit O\nmuch O\nhigher O\nsince O\nmany O\nplayers O\nhad O\nleft O\nearly O\nto O\nstart O\nthe O\nLabor B-MISC\nDay I-MISC\nholiday O\nweekend O\n, O\ntraders O\nsaid O\n. O\n\nNYMEX O\nwill O\nbe O\nclosed O\nMonday O\ndue O\nto O\nLabor B-MISC\nDay I-MISC\n. O\n\n-- O\nHarry B-PER\nMilling I-PER\n, O\nNew B-ORG\nYork I-ORG\nEnergy I-ORG\nDesk I-ORG\n, O\n+1 O\n212-859-1761 O\n\n-DOCSTART- O\n\nU.S. B-LOC\ndebt O\nfutures O\nend O\nlower O\n, O\nshaken O\nby O\nChicago B-LOC\nNAPM B-ORG\n. O\n\nCHICAGO B-LOC\n1996-08-30 O\n\nU.S. B-LOC\ndebt O\nfutures O\nfinished O\na O\nshortened O\npre-holiday O\nsession O\nsharply O\nlower O\n, O\nas O\nthe O\nmarkets O\nwere O\nshaken O\nby O\na O\nstronger O\nthan O\nexpected O\nrise O\nin O\nthe O\nAugust O\nNational B-ORG\nAssociation I-ORG\nof I-ORG\nPurchasing I-ORG\nManagement I-ORG\n( O\nNAPM B-ORG\n) O\nindex O\nfor O\nthe O\nChicago B-LOC\narea O\n, O\ntraders O\nand O\nanalysts O\nsaid O\n. O\n\nThe O\nAugust O\nChicago B-LOC\nNAPM B-ORG\nrose O\n8.8 O\npoints O\nto O\n60.0 O\n, O\nits O\nhighest O\nlevel O\nsince O\n62.6 O\nin O\nFebruary O\n1995 O\nand O\nthe O\nlargest O\nmonthly O\nrise O\nsince O\nDecember O\n1993 O\n. O\n\nPrimary O\ndealers O\nimmediately O\nsold O\nEurodollar B-MISC\nand O\nbond O\nfutures O\n, O\nafter O\nthe O\nmarket O\non O\naverage O\nwas O\nexpecting O\nthe O\nindex O\nto O\nrise O\nmarginally O\nto O\n51.9 O\nfrom O\nJuly O\n's O\n51.2 O\n. O\n\nTraders O\nalso O\nsaid O\nJapanese B-MISC\ninvestors O\nwere O\nunwinding O\nlong O\nEurodollar B-MISC\nfutures O\n/ O\nshort O\nswaps O\n, O\nand O\nthat O\nheavy O\nput O\nbuying O\nhelped O\npressure O\nEurodollars B-MISC\nto O\nlower O\nlevels O\nbefore O\nthe O\nclose O\n. O\n\nOne O\nU.S. B-LOC\nfirm O\nbought O\n35,000 O\nSeptember O\n97 O\nmid-curve O\nput O\noptions O\nat O\na O\nstrike O\nprice O\nof O\n93.25 O\nto O\n93.30 O\nin O\nthe O\nlast O\ntwo O\nsessions O\n, O\nwhile O\na O\nFrench B-MISC\nfirm O\nbought O\n4,000 O\nSeptember O\n93.30 O\nto O\n93.32 O\nput O\nspreads O\n. O\n\n\" O\nEven O\nbefore O\nthe O\ndata O\ncame O\nout O\n, O\nwe O\nwere O\nseeing O\nput O\nbuying O\n, O\n\" O\none O\nfloor O\ntrader O\nsaid O\n. O\n\nMeanwhile O\n, O\nfunds O\nwere O\nreportedly O\ngood O\nsellers O\nof O\nfive-year O\nnotes O\n. O\n\nRumors O\ncirculated O\nthat O\nthe O\nFederal B-ORG\nReserve I-ORG\nwas O\nbuying O\nfive-year O\nnotes O\n, O\nand O\nthat O\na O\nrenowned O\nhedge O\nfund O\nmanager O\nwas O\nbuying O\n10-year O\nnotes O\nin O\nthe O\ncash O\nmarkets O\n. O\n\nHowever O\n, O\nDecember O\nT-bonds O\nended O\nbelow O\na O\nmajor O\ntrendline O\nlevel O\nat O\n106-26/32 O\n, O\nas O\nthe O\nyield O\nin O\nthe O\ncash O\nbond O\nmarket O\nset O\nits O\nhighest O\nmonthly O\nclose O\nsince O\nApril O\n1995 O\nat O\n7.12 O\npercent O\n, O\none O\nanalyst O\nsaid O\n. O\n\nDecember O\nbonds O\nblew O\nthrough O\nthe O\nJuly O\n30 O\nlow O\nof O\n107-06/32 O\n, O\neven O\nthough O\nconditions O\nwere O\nslightly O\noversold O\n, O\ntraders O\nsaid O\n. O\n\nThe O\nDecember O\ncalendar O\nspread O\ncontinued O\nto O\nwiden O\n, O\nalso O\nreflecting O\nthe O\nmarket O\n's O\nfear O\nof O\nrising O\ninflation O\n. O\n\nWhile O\nthe O\nmarket O\ncontinues O\nto O\nprice-in O\nhigher O\nU.S. B-LOC\ninterest O\nrates O\n, O\nthere O\nwas O\nlittle O\nconviction O\nto O\nthe O\ntheory O\nthat O\nthe O\nFederal B-ORG\nReserve I-ORG\nwould O\ntighten O\nrates O\nbefore O\nthe O\nnext O\nFederal B-ORG\nOpen I-ORG\nMarket I-ORG\nCommittee I-ORG\nmeeting O\non O\nSeptember O\n24 O\n. O\n\nFederal B-ORG\nReserve I-ORG\ngovernor O\nLawrence B-PER\nLindsey I-PER\n, O\nspeaking O\non O\nU.S. B-LOC\ncable O\ntelevision O\nnetwork O\nCNBC B-ORG\n, O\nsaid O\nthe O\nU.S. B-LOC\neconomy O\nappears O\non O\nbalance O\nto O\nbe O\na O\nbit O\nstrong O\n, O\nadding O\nthe O\ncentral O\nbank O\nwould O\nnot O\ncurb O\ngrowth O\nprovided O\ninflation O\nremains O\nin O\ncheck O\n. O\n\nEarlier O\nin O\nthe O\nday O\n, O\nFed B-ORG\nchairman O\nAlan B-PER\nGreenspan I-PER\nsaid O\nat O\nthe O\nannual O\nJackson B-MISC\nHole I-MISC\nsymposium I-MISC\nthat O\nthe O\ngoal O\nof O\nprice O\nstability O\nis O\nwithin O\nreach O\nfor O\nmajor O\nnations O\n. O\n\nTraders O\nsaid O\nthe O\nFed B-ORG\n's O\ndecision O\nto O\nadopt O\na O\ntightening O\nbias O\nat O\nthe O\nJuly O\nFOMC B-ORG\nmeeting O\nhas O\ncast O\nmore O\nfocus O\non O\nevery O\npiece O\nof O\nU.S. B-LOC\neconomic O\nnews O\n. O\n\n\" O\nThe O\nFed B-ORG\n's O\nstance O\nhas O\nreally O\nsensitized O\nus O\nto O\nall O\nthis O\ndata O\n, O\n\" O\none O\nanalyst O\nsaid O\n. O\n\" O\n\nThe O\nrevisions O\nto O\nGDP O\n, O\nfor O\nexample O\n, O\nmay O\nnot O\nhave O\nattracted O\na O\nlot O\nof O\nattention O\n. O\n\" O\n\nAt O\nthe O\nend O\nof O\npit O\ntrade O\n, O\nDecember O\nbonds O\nwere O\noff O\n27/32 O\nat O\n106-25/32 O\n, O\n10-year O\nnotes O\ndown O\n21/32 O\nat O\n105-17/32 O\n, O\nmunibonds O\noff O\n17/32 O\nat O\n111-20/32 O\n, O\nDecember O\nEurodollars B-MISC\nwere O\ndown O\n11 O\nbps O\nat O\n93.94 O\n, O\nMarch O\nEurodollars B-MISC\nwere O\noff O\n13 O\nbps O\nat O\n93.72 O\nand O\nMarch O\nT-bills O\nwere O\ndown O\n12 O\nbps O\nat O\n94.33 O\n. O\n\n-DOCSTART- O\n\nDouglas B-ORG\n& I-ORG\nLomason I-ORG\nshares O\nrise O\non O\nmerger O\n. O\n\nFARMINGTON B-LOC\nHILLS I-LOC\n, O\nMich B-LOC\n. O\n\n1996-08-30 O\n\nShares O\nof O\nDouglas B-ORG\n& I-ORG\nLomason I-ORG\nCo I-ORG\nwere O\nup O\n4-1/2 O\nat O\n30-5/8 O\nFriday O\nafternoon O\nafter O\nThursday O\n's O\nannouncement O\nthat O\nthe O\nvehicle O\nseat O\nmaker O\nhad O\nagreed O\nto O\nbe O\nacquired O\nby O\nMagna B-ORG\nInternational I-ORG\nInc I-ORG\nfor O\n$ O\n31 O\na O\nshare O\n, O\nor O\n$ O\n135 O\nmillion O\n. O\n\nMagna B-ORG\nwas O\nup O\n1/8 O\nto O\n48-1/4 O\non O\nthe O\nNew B-ORG\nYork I-ORG\nStock I-ORG\nExchange I-ORG\n. O\n\nDouglas B-ORG\n& I-ORG\nLomason I-ORG\nhas O\n4.45 O\nmillion O\ncommon O\nshares O\noutstanding O\n, O\nsome O\nof O\nwhich O\nare O\noption O\nshares O\nto O\nbe O\npurchased O\nat O\nexercise O\nprices O\nless O\nthan O\nthe O\n$ O\n31 O\noffered O\nprice O\n. O\n\nThe O\nacquisition O\nwill O\nbeef O\nup O\nMarkham B-ORG\n, O\nOntario-based B-MISC\nMagna B-ORG\n's O\nNorth B-MISC\nAmerican I-MISC\ncar O\nand O\ntruck O\nseating O\nbusiness O\n, O\nallowing O\nit O\nto O\nbetter O\ncompete O\nwith O\nJohnson B-ORG\nControls I-ORG\nInc I-ORG\nand O\nLear B-ORG\nCorp I-ORG\n. O\n\nFamily-controlled O\nDouglas B-ORG\n& I-ORG\nLomason I-ORG\n, O\nwhich O\nhad O\n1995 O\nrevenue O\nof O\n$ O\n561 O\nmillion O\n, O\nwas O\nfinding O\nit O\nmore O\ndifficult O\nto O\ncompete O\nfor O\nnew O\nseating O\ncontracts O\nfrom O\nvehicle O\nmakers O\n, O\nsaid O\nJames B-PER\nHoey I-PER\n, O\nchief O\nfinancial O\nofficer O\n. O\n\n\" O\nUnfortunately O\n, O\nin O\nthe O\nauto O\nindustry O\nthese O\ndays O\n, O\na O\n$ O\n500 O\nmillion O\ncompany O\nis O\nnot O\na O\nbig O\ncompany O\nanymore O\n, O\n\" O\nHoey B-PER\nsaid O\n. O\n\" O\n\nThis O\nmerger O\nmakes O\nus O\nmuch O\nmore O\ncompetitive O\n. O\n\" O\n\nHe O\nadded O\nthat O\nDouglas B-ORG\n& I-ORG\nLomason I-ORG\n's O\ntop O\nexecutives O\nhave O\nbeen O\nasked O\nto O\nstay O\non O\nwith O\nMagna B-ORG\nafter O\nthe O\nmerger O\n, O\nthough O\ntheir O\nfuture O\nroles O\nhave O\nnot O\nyet O\nbeen O\ndefined O\n. O\n\nDouglas B-ORG\n& I-ORG\nLomason I-ORG\n's O\nprofits O\nwere O\nhurt O\nin O\nthe O\npast O\nyear O\nby O\nmodel O\nchangeovers O\n, O\nwhich O\nhad O\nreduced O\nproduction O\nat O\nsome O\nimportant O\ncustomers O\n, O\nbut O\nare O\nnow O\nrecovering O\n, O\nanalysts O\nsaid O\n. O\n\nThe O\ncompany O\nearned O\n$ O\n11.2 O\nmillion O\non O\nsales O\nof O\n$ O\n299 O\nmillion O\nin O\nthe O\nfirst O\nsix O\nmonths O\nof O\n1996 O\n, O\nup O\nfrom O\nyear-earlier O\nearnings O\nof O\n$ O\n4.7 O\nmillion O\non O\nsales O\nof O\n$ O\n285.7 O\nmillion O\n. O\n\nFord B-ORG\nplans O\nto O\ncut O\nits O\nroster O\nof O\n2,300 O\ntier-one O\nsuppliers O\n-- O\nthose O\nit O\ndeals O\nwith O\ndirectly O\n-- O\nin O\nhalf O\nover O\nthe O\nnext O\nfive O\nyears O\n. O\n\n\" O\nThe O\ndeal O\nreally O\nlevels O\nthe O\nseating O\nfield O\nsomewhat O\n, O\n\" O\nsaid O\nJohn B-PER\nCasesa I-PER\nof O\nSchroder B-ORG\nWertheim I-ORG\n& I-ORG\nCo I-ORG\n. O\n\" O\n\nIt O\nshould O\ngive O\nMagna B-ORG\nthe O\ncritical O\nmass O\nto O\nbe O\na O\nbigger O\nplayer O\nin O\nthat O\nmarket O\n. O\n\" O\n\nMagna B-ORG\n's O\ntraditional O\nstrength O\nhas O\nbeen O\ninstrument O\npanels O\n, O\ndoor O\npanels O\nand O\nother O\ninterior O\ncomponents O\n. O\n\nMagna B-ORG\n, O\nJohnson B-ORG\nControls I-ORG\nand O\nLear B-ORG\nhave O\nbeen O\nworking O\nto O\nbuild O\nup O\ntheir O\ncapabilties O\nto O\nsupply O\ncomplete O\ninteriors O\nto O\nautomakers O\n, O\nincluding O\nseats O\n, O\ninstrument O\npanels O\n, O\ndoor O\npanels O\ncarpeting O\nand O\nheadliners O\n. O\n\n-DOCSTART- O\n\nUK B-LOC\nmeals O\n/ O\nfeeds O\nfollow O\nChicago B-LOC\nhigher O\n, O\ntrade O\nslow O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nUK B-LOC\nmeals O\nand O\nfeeds O\nsellers O\nmarked O\nup O\nhigh O\nprotein O\nsoymeal O\nby O\naround O\n1.50 O\nstg O\na O\ntonne O\non O\nFriday O\nfollowing O\ngains O\nin O\nChicago B-LOC\nat O\nThursday O\n's O\nclose O\n. O\n\nTrade O\nwas O\nvery O\nquiet O\nwith O\nonly O\none O\ndeal O\nreported O\nwhen O\nspot O\nhigh O\nprotein O\nsoymeal O\nfetched O\n215 O\nstg O\na O\ntonne O\nex-store O\non O\nthe O\nsouth O\ncoast O\n. O\n\n\" O\nI O\nwould O\nn't O\nget O\ntoo O\nexcited O\nabout O\nthis O\none O\nbecuase O\nI O\nthink O\nit O\n's O\nfor O\nall O\nof O\nfive O\ntonnes O\n, O\nwhich O\nwhen O\nyou O\nthink O\nabout O\njust O\nabout O\nsums O\nup O\nthe O\nstate O\nof O\nthe O\nmarket O\nat O\nthe O\nmoment O\n, O\n\" O\nsaid O\na O\ntrader O\n. O\n\n-- O\nJim B-PER\nBallantyne I-PER\n, O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n8062 O\n\n-DOCSTART- O\n\nIraqi B-MISC\ncaptors O\nof O\nSudanese B-MISC\njet O\ncharged O\nwith O\nhijack O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nSeven O\nIraqis B-MISC\nwho O\nseized O\na O\nSudanese B-MISC\nairliner O\nwith O\n199 O\npeople O\naboard O\nand O\nforced O\nit O\nto O\nfly O\nto O\nLondon B-LOC\nwere O\non O\nFriday O\ncharged O\nwith O\nhijack O\n, O\nending O\nspeculation O\nthat O\nthey O\nmight O\nbe O\noffered O\nimmediate O\nasylum O\nin O\nBritain B-LOC\n. O\n\nPolice O\nsaid O\nthe O\nseven O\nmen O\n, O\nwho O\nfreed O\nall O\ntheir O\nhostages O\nafter O\nthe O\nplane O\nlanded O\nat O\nStansted B-LOC\nairport O\non O\nTuesday O\nand O\nthen O\nappealed O\nfor O\nasylum O\n, O\nwould O\nappear O\nin O\ncourt O\non O\nSaturday O\n. O\n\nThe O\nIraqis B-MISC\nclaimed O\nthey O\nwere O\n\" O\nordinary O\npeople O\npersecuted O\nby O\nthe O\nregime O\nof O\nSaddam B-PER\n( O\nHussein B-PER\n) O\n\" O\nbut O\ninterior B-ORG\nministry I-ORG\nofficials O\nhad O\nconsistently O\nsaid O\nit O\nwas O\nlikely O\nthe O\nseven O\nwould O\nbe O\ncharged O\nwith O\nhijack O\nbefore O\nany O\nplea O\nfor O\nasylum O\nwas O\nconsidered O\n. O\n\nUnder O\nEnglish B-MISC\nlaw O\nthe O\nmaximum O\nsentence O\nfor O\nhijack O\nis O\nlife O\nimprisonment O\n, O\nbut O\nthere O\nhas O\nbeen O\nwidespread O\nspeculation O\nthat O\nthe O\nseven O\nwill O\nreceive O\nlesser O\nsentences O\nand O\nthen O\nbe O\nallowed O\nto O\nstay O\nrather O\nthan O\nbeing O\nsent O\nback O\nto O\nIraq B-LOC\n. O\n\nThe O\nhijack O\nbegan O\non O\nMonday O\nwhen O\nan O\nAmman-bound B-MISC\nplane O\nwas O\ntaken O\nover O\nshortly O\nafter O\nit O\ntook O\noff O\nfrom O\nKhartoum B-LOC\n. O\n\nThe O\nhijackers O\nthreatened O\nto O\nblow O\nit O\nup O\nduring O\na O\nrefuelling O\nstop O\nin O\nCyprus B-LOC\nunless O\nthey O\nwere O\ntaken O\nto O\nLondon B-LOC\n. O\n\nAfter O\na O\nsearch O\nof O\nthe O\naircraft O\nfollowing O\nthe O\nhijackers O\n' O\nsurrender O\n, O\npolice O\nfound O\nonly O\nknives O\nand O\nfake O\nexplosives O\n. O\n\n-DOCSTART- O\n\nLate O\nbond O\nmarket O\nprices O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nThis O\nis O\nhow O\nmajor O\nworld O\nbond O\nmarkets O\nwere O\ntrading O\nin O\nlate O\nEuropean B-MISC\nbusiness O\non O\nFriday O\n. O\n\nGERMANY B-LOC\n- O\nBunds O\nextended O\nlosses O\n, O\nflirting O\nwith O\nsession O\nlows O\nafter O\nfalling O\nvictim O\nto O\nsharply O\nhigher O\nU.S. B-LOC\neconomic O\ndata O\nwhich O\nrevived O\nfears O\nthat O\ninterest O\nrates O\nmay O\nsoon O\nturn O\nhigher O\n. O\n\nThe O\nSeptember O\nBund O\nfuture O\non O\nthe O\nLondon B-ORG\nInternational I-ORG\nFinancial I-ORG\nFutures I-ORG\nand I-ORG\nOptions I-ORG\nExchange I-ORG\n( O\nLIFFE B-ORG\n) O\nwas O\ntrading O\nat O\n97.18 O\n, O\ndown O\n0.20 O\nfrom O\nThursday O\n's O\nsettlement O\nprice O\n. O\n\nBRITAIN B-LOC\n- O\nGilts O\nstruggled O\noff O\nthe O\nday O\n's O\nlows O\nbut O\nended O\n10/32 O\ndown O\non O\nthe O\nday O\n. O\n\nA O\nsharp O\nplunge O\nin O\nU.S. B-ORG\nTreasuries I-ORG\nafter O\na O\nshock O\nrise O\nin O\nthe O\nChicago B-MISC\nPMI I-MISC\npulled O\ngilts O\nlower O\n, O\nbut O\ntraders O\nsaid O\nthe O\nmarket O\nwas O\nnervous O\nanyway O\nahead O\nof O\nAugust O\nMO O\ndata O\nand O\nthe O\nPMI O\nsurvey O\ndue O\non O\nMonday O\n. O\n\nThe O\nSeptember O\nlong O\ngilt O\nfuture O\non O\nLIFFE B-ORG\nwas O\ntrading O\nat O\n107-2/32 O\n, O\ndown O\n8/32 O\nfrom O\nThursday O\n's O\nsettlement O\nprice O\n. O\n\nFRANCE B-LOC\n- O\nBond O\nand O\nPIBOR O\nfutures O\nended O\nthe O\nday O\nhigher O\ndespite O\nmuch O\nstronger O\nthan O\nexpected O\nU.S. B-LOC\ndata O\n. O\n\nThe O\nSeptember O\nnotional O\nbond O\nfuture O\non O\nthe O\nMATIF O\nin O\nParis B-LOC\nsettled O\nat O\n123.14 O\n, O\nup O\n0.04 O\nfrom O\nThursday O\n's O\nsettlement O\nprice O\n. O\n\nITALY B-LOC\n- O\nBond O\nfutures O\nheld O\nto O\neasier O\nlevels O\nin O\nlate O\nafternoon O\nafter O\nthe O\nsharp O\ndrop O\nin O\nTreasuries B-ORG\n, O\nbut O\na O\nresilient O\nlira O\nhelped O\nlimit O\nBTP O\nlosses O\n. O\n\nThe O\nSeptember O\nbond O\nfuture O\non O\nLIFFE B-ORG\nwas O\ntrading O\nat O\n115.45 O\n, O\ndown O\n0.13 O\nfrom O\nThursday O\n's O\nsettlement O\nprice O\n. O\n\nUNITED B-LOC\nSTATES I-LOC\n- O\nPrices O\nof O\nU.S. B-ORG\nTreasury I-ORG\nsecurities O\nwere O\ntrading O\nsharply O\nlower O\nnear O\nmidday O\nafter O\na O\nsurprisingly O\nstrong O\nChicago B-ORG\nPurchasing I-ORG\nManagers I-ORG\n' O\nreport O\nshook O\nthe O\nmarkets O\nahead O\nof O\nthe O\nlong O\nLabour B-MISC\nDay I-MISC\nweekend O\n. O\n\nThe O\nSeptember O\nTreasury B-ORG\nbond O\nfuture O\non O\nthe O\nChicago B-ORG\nBoard I-ORG\nof I-ORG\nTrade I-ORG\nwas O\ntrading O\nat O\n107-11/32 O\n, O\ndown O\n26/32 O\nfrom O\nThursday O\n's O\nsettlement O\nprice O\n. O\n\nThe O\nlong O\nbond O\nwas O\nquoted O\nto O\nyield O\n7.12 O\npercent O\n. O\n\nJAPAN B-LOC\n- O\nYield O\nfor O\nbenchmark O\n182nd O\ncash O\nbond O\nfell O\non O\nbuy-backs O\nfollowing O\nweaker-than-expected O\nindustrial O\noutput O\ndata O\n, O\nwhich O\nconvinced O\ntraders O\nthe O\nBOJ B-ORG\nwould O\nnot O\nraise O\ninterest O\nrates O\nsoon O\n. O\n\nJapanese B-MISC\nGoverment I-MISC\nBonds I-MISC\nfutures O\nwhich O\nclosed O\nbefore O\nthe O\noutput O\ndata O\n, O\nlost O\nmuch O\nof O\nday O\n's O\ngains O\nas O\nTokyo B-LOC\nstock O\nprices O\nrecovered O\nfrom O\nthe O\nday O\n's O\nlow.In O\nafter O\nhours O\ntrading O\nthe O\nSeptember O\nfuture O\non O\nLIFFE B-ORG\nwas O\ntrading O\nat O\n122.53 O\n, O\nup O\n0.26 O\nfrom O\nThursday O\n's O\nsettlement O\nprice O\non O\nthe O\nTokyo B-ORG\nStock I-ORG\nExchange I-ORG\n. O\n\nEUROBONDS B-MISC\n- O\nPrimary O\nmarket O\nactivity O\nwas O\nsharply O\nlower O\n, O\nas O\nplayers O\nwound O\ndown O\nahead O\nof O\nMonday O\n's O\nU.S. B-LOC\nLabour B-MISC\nDay I-MISC\nholiday O\nand O\nnext O\nweek O\n's O\nU.S. B-LOC\nemployment O\ndata O\n. O\n\nNSW B-ORG\nTreasury I-ORG\nlaunched O\na O\nA$ B-MISC\n100 O\nmillion O\nthree-year O\ndiscount O\nbond O\naimed O\nat O\nJapanese B-MISC\ninvestors O\n. O\n\nDNIB B-ORG\nissued O\na O\n275 O\nmillion O\nNorwegian B-MISC\ncrown O\nbond O\n, O\nwhich O\nwas O\npre-placed O\nwith O\na O\nEuropean B-MISC\ninstitution O\n. O\n\nDNIB B-ORG\nalso O\nset O\na O\n110 O\nmillion O\nguilder O\nstep-up O\nbond O\n. O\n\nNext O\nweek O\nKansai B-ORG\nElectric I-ORG\nPower I-ORG\nand O\nKansai B-ORG\nInternational I-ORG\nAirport I-ORG\nare O\nlikely O\nto O\nlaunch O\n10-year O\ndollar O\ndeals O\n. O\n\n-DOCSTART- O\n\nBoxing-Bruno B-MISC\nquits O\non O\ndoctor O\n's O\nadvice O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nFormer O\nworld O\nheavyweight O\nchampion O\nFrank B-PER\nBruno I-PER\nhas O\nquit O\nthe O\nring O\non O\nmedical O\nadvice O\n, O\nBritain B-LOC\n's O\nSun B-ORG\nnewspaper O\nreported O\non O\nFriday O\n. O\n\nAn O\neye O\nspecialist O\ntold O\nthe O\n35-year-old O\nBruno B-PER\nthat O\nhe O\ncould O\nbe O\nblinded O\nin O\none O\neye O\nif O\nhe O\nboxed O\nagain O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nThe O\nBriton B-MISC\n, O\nwho O\nlost O\nhis O\nWorld B-ORG\nBoxing I-ORG\nCouncil I-ORG\n( O\nWBC B-ORG\n) O\ntitle O\nto O\nMike B-PER\nTyson I-PER\nin O\nMarch O\n, O\nsaid O\n: O\n\" O\nI O\nwas O\nin O\nshock O\nas O\nsoon O\nas O\nhe O\ntold O\nme O\nand O\nit O\nstill O\nhas O\nn't O\nreally O\nsunk O\nin O\n. O\n\n\" O\nI O\nnever O\nwanted O\nto O\nend O\nlike O\nthis O\nbut O\nat O\nthe O\nend O\nof O\nthe O\nday O\nI O\n'm O\nglad O\nI O\nhad O\na O\ngood O\ninnings O\n. O\n\" O\n\nBruno B-PER\n, O\nfor O\nyears O\none O\nof O\nBritain B-LOC\n's O\nmost O\npopular O\nsportsmen O\n, O\nhad O\nhoped O\nto O\nhave O\nanother O\nshot O\nat O\nthe O\nworld O\ntitle O\nand O\nhad O\nbeen O\nin O\ntraining O\nuntil O\na O\nroutine O\neye O\ntest O\non O\nMonday O\nhighlighted O\na O\nproblem O\nwith O\nhis O\nright O\neye O\n. O\n\nProfessor O\nDavid B-PER\nMcLeod I-PER\n, O\nwho O\nexamined O\nBruno B-PER\n, O\ntold O\nthe O\nSun B-ORG\n: O\n\" O\nThere O\nis O\na O\nrisk O\nhe O\ncould O\nbe O\nblinded O\nin O\nthe O\neye O\nif O\nhe O\nsteps O\ninto O\nthe O\nring O\nagain O\n. O\n\nHe O\nis O\nin O\ndanger O\nof O\ngetting O\na O\nretinal O\ndetachment O\nand O\nthere O\nis O\nno O\npoint O\nin O\nexposing O\nhimself O\nto O\nthat O\n. O\n\" O\n\nBruno B-PER\nlost O\nthree O\nworld O\ntitle O\nfights O\nbefore O\nfinally O\nlanding O\nthe O\ncrown O\nby O\nbeating O\nAmerican B-MISC\nOliver B-PER\nMcCall I-PER\nin O\na O\nunanimous O\npoints O\ndecision O\nat O\nWembley B-LOC\nin O\nSeptember O\n1995 O\n. O\n\nHe O\nwas O\nonly O\nthe O\nthird O\nBriton B-MISC\never O\nto O\nhold O\na O\nworld O\nheavyweight O\ntitle O\n. O\n\nBut O\nBruno B-PER\nlost O\nthe O\ntitle O\non O\nhis O\nfirst O\ndefence O\nwhen O\nhe O\nfought O\nAmerican B-MISC\nTyson B-PER\nin O\nLas B-LOC\nVegas I-LOC\n. O\n\nBruno B-PER\nsuffered O\na O\ncut O\neye O\nin O\nthe O\nopening O\nround O\nand O\nthe O\nreferee O\nstopped O\nthe O\nfight O\nin O\nthe O\nthird O\nas O\nthe O\nBriton B-MISC\ncrumbled O\nunder O\na O\nflurry O\nof O\npunches O\n. O\n\n-DOCSTART- O\n\nSoccer O\n- O\nMcCarthy B-PER\nnames O\nteam O\nto O\nplay O\nLiechtenstein B-LOC\n. O\n\nDUBLIN B-LOC\n1996-08-30 O\n\nIrish B-MISC\nsoccer O\nmanager O\nMick B-PER\nMcCarthy I-PER\non O\nFriday O\nannounced O\nthe O\nteam O\nto O\nplay O\nLiechtenstein B-LOC\nin O\nSaturday O\n's O\nWorld B-MISC\nCup I-MISC\nqualifying O\nmatch O\n. O\n\nBirmingham B-ORG\n's O\nGary B-PER\nBreen I-PER\nwas O\nselected O\nahead O\nof O\nPhil B-PER\nBabb I-PER\nin O\ndefence O\n, O\nwhile O\n18-year-old O\nIan B-PER\nHarte I-PER\nmakes O\nhis O\ninternational O\ncompetitive O\ndebut O\n. O\n\nKeith B-PER\nO'Neill I-PER\nof O\nNorwich B-ORG\nCity I-ORG\njoins O\nNiall B-PER\nQuinn I-PER\nup O\nfront O\n. O\n\nThe O\nteam O\nis O\nas O\nfollows O\n: O\n\nGiven B-PER\n, O\nBreen B-PER\n, O\nStaunton B-PER\n, O\nIrwin B-PER\n, O\nMcAteer B-PER\n, O\nHarte B-PER\n, O\nMcLoughlin B-PER\n, O\nHoughton B-PER\n, O\nTownsend B-PER\n, O\nQuinn B-PER\n, O\nO'Neill B-PER\n. O\n\n-- O\nDublin B-ORG\nNewsroom I-ORG\n+353 O\n1 O\n676 O\n9779 O\n\n-DOCSTART- O\n\nNigerian B-MISC\nthieves O\nhire O\npolice O\ntruck O\nto O\ncarry O\nloot O\n. O\n\nLAGOS B-LOC\n1996-08-30 O\n\nA O\ngang O\nof O\nthieves O\nin O\neastern O\nNigeria B-LOC\npaid O\na O\npolice O\ncorporal O\nto O\ncarry O\noff O\neight O\nair O\nconditioners O\nthey O\nhad O\njust O\nstolen O\n, O\nthe O\nnational O\nnews O\nagency O\nreported O\non O\nFriday O\n. O\n\n\" O\nLittle O\ndid O\nI O\nknow O\nI O\nwas O\ndealing O\nwith O\nrobbers O\n, O\n\" O\nthe O\nNews B-ORG\nAgency I-ORG\nof I-ORG\nNigeria I-ORG\nquoted O\nthe O\nunnamed O\ncorporal O\nas O\nsaying O\n. O\n\nHe O\nadmitted O\nto O\nhaving O\nbeen O\npaid O\n3,000 O\nnaira O\n( O\n$ O\n37.50 O\n) O\nfor O\nhis O\nservices O\nin O\ntransporting O\nthe O\nloot O\nvalued O\nat O\n300,000 O\nnaira O\n( O\n$ O\n3,750 O\n) O\n. O\n\nPolice O\nin O\nthe O\ntown O\nof O\nUyo B-LOC\nsaid O\nthe O\ncorporal O\nhad O\nbeen O\narrested O\n, O\nwhile O\nthe O\nair O\nconditioners O\nhad O\nbeen O\nreturned O\nto O\ntheir O\nrightful O\nowner O\n. O\n\nThey O\ndid O\nnot O\ncomment O\non O\nthe O\nwhereabouts O\nof O\nthe O\nthieves O\n. O\n\n( O\n$ O\n1=80 O\nnaira O\n) O\n\n-DOCSTART- O\n\nEast B-ORG\nDries I-ORG\nminers O\nfail O\nto O\nreport O\nfor O\nwork O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-30 O\n\nWorkers O\nat O\nDriefontein B-ORG\nConsolidated I-ORG\nLtd I-ORG\n's O\neast O\ngold O\nmine O\nhave O\nfailed O\nto O\nreport O\nfor O\nwork O\nsince O\nWednesday O\nnight O\n, O\nmine O\nmanagers O\nGold B-ORG\nFields I-ORG\nof I-ORG\nSouth I-ORG\nAfrica I-ORG\nLtd I-ORG\nsaid O\non O\nFriday O\n. O\n\n\" O\nDiscussions O\nwith O\nemployee O\nand O\nunion O\nrepresentatives O\nare O\ncontinuing O\n, O\n\" O\nthe O\ncompany O\nsaid O\nin O\na O\nstatement O\n. O\n\nIt O\ngave O\nno O\nfurther O\ndetails O\n. O\n\nAt O\nleast O\n17 O\nminers O\nhave O\nbeen O\nkilled O\nin O\nlabour O\nunrest O\n-- O\nsparked O\nby O\nethnic O\ndifferences O\n-- O\nat O\nDriefontein B-ORG\nConsolidated I-ORG\nand I-ORG\nGold I-ORG\nFields I-ORG\n' I-ORG\nKloof I-ORG\nGold I-ORG\nMining I-ORG\nCo I-ORG\nthis O\nmonth O\n. O\n\n-- O\nJohannesburg B-LOC\nnewsroom O\n, O\n+27-11 O\n482 O\n1003 O\n\n-DOCSTART- O\n\nChad B-LOC\ngovernment O\ncloses O\nuniversity O\nafter O\nprotests O\n. O\n\nN'DJAMENA B-LOC\n1996-08-30 O\n\nThe O\ngovernment O\nof O\nChad B-LOC\nhas O\nclosed O\nN'Djamena B-ORG\nUniversity I-ORG\nafter O\ntwo O\ndays O\nof O\nprotests O\nover O\ngrant O\narrears O\nin O\nwhich O\nEducation O\nMinister O\nNagoum B-PER\nYamassoum I-PER\nwas O\nheld O\nhostage O\nfor O\nfour O\nhours O\n, O\nstate O\nradio O\nsaid O\non O\nFriday O\n. O\n\n\" O\nThe O\nminister O\nand O\nhis O\ncolleagues O\nwho O\nwere O\nheld O\nin O\nthe O\nrector O\n's O\noffice O\nwere O\nfreed O\nthanks O\nan O\nintervention O\nby O\ngendarmes O\n, O\n\" O\none O\nuniversity O\nofficial O\nsaid O\n. O\n\n\" O\nAngry O\nstudents O\ncut O\nthe O\ntelephone O\n, O\nwater O\nand O\nelectricity O\nof O\nthe O\nuniversity O\noffices O\nbefore O\nsmashing O\nthe O\nwindows O\nand O\nbreaking O\ndown O\nthe O\ndoors O\n. O\n\" O\n\nParamilitary O\npolice O\ndetained O\nmore O\nthan O\n120 O\nstudents O\nin O\nthe O\nprotest O\n. O\n\nThe O\nstudents O\n' O\nunion O\nsaid O\nsecond O\nand O\nthird-year O\nstudents O\nwere O\ndemanding O\nfour O\nmonths O\nof O\nunpaid O\ngrants O\n. O\n\nEnd-of-year O\nexaminations O\nwould O\ngo O\nahead O\non O\nSeptember O\n2 O\ndespite O\nthe O\nclosure O\n, O\nuniversity O\nofficials O\nsaid O\n. O\n\n-DOCSTART- O\n\nYeltsin B-PER\nendorses O\nLebed B-PER\nChechnya B-LOC\npeace O\nplan O\n- O\nagency O\n. O\n\nMOSCOW B-LOC\n1996-08-30 O\n\nRussian B-MISC\nPrime O\nMinister O\nViktor B-PER\nChernomyrdin I-PER\nsaid O\non O\nFriday O\nthat O\nPresident O\nBoris B-PER\nYeltsin I-PER\n, O\nwho O\nis O\nvacationing O\noutside O\nMoscow B-LOC\n, O\nhad O\nbacked O\nsecurity O\nchief O\nAlexander B-PER\nLebed I-PER\n's O\npeace O\nplan O\nfor O\nChechnya B-LOC\n, O\nInterfax B-ORG\nnews O\nagency O\nsaid O\n. O\n\n\" O\nLebed B-PER\nis O\nnow O\nin O\nChechnya B-LOC\nsolving O\nsome O\nproblems O\n, O\n\" O\nInterfax B-ORG\nquoted O\nChernomyrdin B-PER\nas O\nsaying O\n. O\n\" O\n\nThe O\nmain O\nthing O\nis O\nhis O\nprogramme O\n. O\n\nIt O\nwas O\nagreed O\nwith O\nBoris B-PER\nNikolayevich I-PER\n( O\nYeltsin B-PER\n) O\nyesterday O\n. O\n\" O\n\nLebed B-PER\n, O\nwhom O\nYeltsin B-PER\nordered O\nto O\nrestore O\npeace O\nin O\nChechnya B-LOC\n, O\nstruck O\na O\nmilitary O\ndeal O\nwith O\nseparatist O\nrebels O\nlast O\nweek O\nending O\nthe O\nworst O\nfighting O\nin O\nthe O\nregion O\nin O\nmore O\nthan O\na O\nyear O\n. O\n\nHe O\nlater O\ndiscussed O\nwith O\nrebel O\nchief-of-staff O\nAslan B-PER\nMaskhadov I-PER\na O\nframework O\npolitical O\nagreement O\nto O\ntackle O\nthe O\nmost O\npainful O\nissue O\nof O\nthe O\n20-month O\nwar O\n-- O\nthe O\nfuture O\npolitical O\nstatus O\nof O\nChechnya B-LOC\n. O\n\nLebed B-PER\nsaid O\non O\nFriday O\nhe O\nhoped O\nto O\nsign O\na O\ndocument O\nwith O\nthe O\nrebels O\nlater O\nin O\nthe O\nday O\nwhich O\nwould O\ndeal O\nwith O\nthe O\npolitical O\nsettlement O\nof O\nthe O\nconflict O\n. O\n\nMoscow B-LOC\n, O\nwhich O\nwants O\nto O\nkeep O\nChechnya B-LOC\nas O\na O\npart O\nof O\nthe O\nRussian B-LOC\nFederation I-LOC\n, O\nsent O\ntroops O\nto O\nthe O\nregion O\nin O\nDecember O\n1994 O\nto O\nquell O\nits O\nindependence O\nbid O\n. O\n\nYeltsin B-PER\nhas O\nsaid O\nany O\ndeal O\nshould O\npreserve O\nRussia B-LOC\n's O\nterritorial O\nintegrity O\n. O\n\nItar-Tass B-ORG\nnews O\nagency O\nquoted O\nLebed B-PER\nas O\nsaying O\nthat O\nhe O\nwould O\nsuggest O\nto O\nthe O\nrebels O\nthat O\nthe O\ndecision O\non O\nChechnya B-LOC\n's O\nfuture O\npolitical O\nstatus O\nbe O\ndeferred O\nby O\nup O\nto O\n10 O\nyears O\n. O\n\nLebed B-PER\nsaid O\nhe O\nhad O\na O\ntelephone O\nconversation O\nwith O\nYeltsin B-PER\nlate O\non O\nThursday O\nbut O\ngave O\nno O\ndetails O\n. O\n\nYeltsin B-PER\n's O\npress O\noffice O\ncould O\nnot O\nconfirm O\nthe O\ncall O\n. O\n\nChernomyrdin B-PER\nsaid O\non O\nThursday O\nafter O\na O\nmeeting O\nwith O\nLebed B-PER\nand O\ntop O\nofficials O\n, O\nwho O\ndiscussed O\nLebed B-PER\n's O\nplans O\nto O\nrestore O\npeace O\nin O\nChechnya B-LOC\n, O\nthat O\nit O\nneeded O\nmore O\nwork O\n. O\n\n-DOCSTART- O\n\nLebed B-PER\n, O\nChechens B-MISC\nsign O\nframework O\npolitical O\ndeal O\n. O\n\nKHASAVYURT B-LOC\n, O\nRussia B-LOC\n1996-08-31 O\n\nRussian B-MISC\npeacemaker O\nAlexander B-PER\nLebed I-PER\nsaid O\nhe O\nand O\nrebel O\nmilitary O\nleader O\nAslan B-PER\nMaskhadov I-PER\nagreed O\nafter O\novernight O\ntalks O\nto O\ndefer O\nthe O\ndecision O\non O\nwhether O\nChechnya B-LOC\nshould O\nbe O\nindependent O\nuntil O\nDecember O\n31 O\n, O\n2001 O\n. O\n\n\" O\nWe O\njust O\nnow O\nsigned O\na O\nstatement O\nand O\nattached O\nthe O\nbasic O\nprinciples O\nof O\nrelations O\nbetween O\nthe O\nRussian B-LOC\nFederation I-LOC\nand O\nthe O\nChechen B-LOC\nRepublic I-LOC\n, O\n\" O\nLebed B-PER\ntold O\nreporters O\nafter O\nhe O\nand O\nMaskhadov B-PER\nsigned O\na O\npackage O\nof O\ndocuments O\n. O\n\nHe O\ngave O\nno O\nfurther O\ndetails O\n. O\n\n\" O\nThat O\n's O\nit O\n, O\nthe O\nwar O\nis O\nover O\n, O\n\" O\nLebed B-PER\ntold O\nreporters O\nwho O\nwitnessed O\nthe O\nsigning O\n. O\n\nLebed B-PER\nsaid O\nhe O\nand O\nMaskhadov B-PER\nagreed O\nto O\ndefer O\nby O\nmore O\nthan O\nfive O\nyears O\nthe O\npainful O\nissue O\nof O\nChechnya B-LOC\n's O\npolitical O\nstatus O\n. O\n\n\" O\nThen O\n, O\nwith O\ncool O\nheads O\n, O\ncalmly O\nand O\nsoberly O\nwe O\nwill O\nsort O\nout O\nour O\nrelations O\n, O\n\" O\nLebed B-PER\nsaid O\nafter O\nthe O\nlate-night O\nsigning O\nceremony O\nin O\nthis O\nsettlement O\noutside O\nChechnya B-LOC\n's O\neastern O\nborder O\n. O\n\nTens O\nof O\nthousands O\nof O\npeople O\nhave O\ndied O\nin O\nthe O\nwar O\n, O\nbegun O\nin O\nlate O\n1994 O\nafter O\nMoscow B-LOC\nsent O\ntroops O\nto O\nquell O\nChechnya B-LOC\n's O\nindependence O\nbid O\n. O\n\nBut O\nRussia B-LOC\nfailed O\nto O\nwin O\ncontrol O\nover O\nthe O\nwhole O\nof O\nChechnya B-LOC\nand O\nits O\ntroops O\nsuffered O\nseveral O\nhumiliating O\ndefeats O\n. O\n\nPresident O\nBoris B-PER\nYeltsin I-PER\nordered O\nLebed B-PER\nto O\nrestore O\npeace O\nin O\nChechnya B-LOC\nand O\ngave O\nhim O\nunspecified O\nsweeping O\npowers O\nto O\ncarry O\nout O\nthe O\nmission O\n. O\n\nPrime O\nMinister O\nViktor B-PER\nChernomyrdin I-PER\nsaid O\non O\nFriday O\nthat O\nYeltsin B-PER\nbacked O\na O\npackage O\nof O\nproposals O\nLebed B-PER\ntook O\nto O\nthe O\ntalks O\n. O\n\n-DOCSTART- O\n\nRuling O\nMoslem B-MISC\nparty O\nends O\nvote O\nboycott O\n. O\n\nSARAJEVO B-LOC\n1996-08-30 O\n\nBosnia B-LOC\n's O\nruling O\nMoslem B-MISC\nnationalist O\nparty O\non O\nFriday O\ncalled O\non O\nits O\nrefugee O\nvoters O\nto O\nend O\na O\nboycott O\nof O\nabsentee O\nballoting O\nin O\nnational O\nelections O\n, O\nciting O\nassurances O\nprovided O\nby O\na O\nU.S. B-LOC\nenvoy O\n, O\ngovernment O\nradio O\nsaid O\n. O\n\nThe O\nBosnian B-MISC\ngovernment O\nradio O\nbroadcast O\nsaid O\nU.S. B-LOC\nAssistant O\nSecretary O\nof O\nState O\nJohn B-PER\nKornblum I-PER\nhad O\nreassured O\nSDA B-ORG\nofficials O\n, O\nincluding O\npresumably O\nits O\nleader O\n, O\nBosnian B-MISC\nPresident O\nAlija B-PER\nIzetbegovic I-PER\n, O\nwhom O\nhe O\nmet O\nduring O\na O\nFriday O\nvisit O\n. O\n\nBut O\nthe O\nradio O\nreport O\ndid O\nnot O\nspecify O\nwhat O\nguarantees O\n, O\nif O\nany O\n, O\nthe O\nU.S. B-LOC\nenvoy O\nhad O\nprovided O\n. O\n\nAbsentee O\nvoting O\nin O\nthe O\nelections O\nbegan O\non O\nWednesday O\n, O\nAugust O\n28 O\nand O\nruns O\nfor O\na O\nweek O\n. O\n\nElection O\nday O\nfor O\nthose O\nliving O\ninside O\nBosnia B-LOC\nis O\nSeptember O\n14 O\n. O\n\nThe O\nParty B-ORG\nof I-ORG\nDemocratic I-ORG\nAction I-ORG\n( O\nSDA B-ORG\n) O\nhad O\ncalled O\non O\nWednesday O\nfor O\nits O\nfollowers O\nabroad O\nto O\nboycott O\nthe O\nabsentee O\nballoting O\nbecause O\nof O\nvoter O\nregistration O\nirregularities O\n, O\nespecially O\namong O\nSerb B-MISC\nrefugees O\n. O\n\nThe O\nOrganisation B-ORG\nfor I-ORG\nSecurity I-ORG\nand I-ORG\nCooperation I-ORG\nin I-ORG\nEurope I-ORG\n( O\nOSCE B-ORG\n) O\npostponed O\nmunicipal O\nelections O\nas O\na O\nresult O\nof O\nthe O\nirregularities O\nbut O\ndecided O\nto O\nproceed O\nwith O\nvoting O\nfor O\nhigher O\noffices O\n. O\n\nThe O\nSDA B-ORG\n, O\njoined O\nby O\ntwo O\nother O\nparties O\n, O\nhas O\nbeen O\ndemanding O\nthat O\nOSCE B-ORG\nprohibit O\nrefugees O\nvoting O\nfrom O\nany O\nplace O\nother O\nthan O\ntheir O\npre-war O\nplace O\nof O\nresidence O\nas O\na O\nmeans O\nto O\nprevent O\nthe O\nelections O\nfrom O\nratifying O\nthe O\nresults O\nof O\nethnic O\ncleansing O\n. O\n\n-DOCSTART- O\n\nBelgrade B-LOC\nairport O\nrunway O\nrepairs O\nSept O\n21-26-agency O\n. O\n\nBELGRADE B-LOC\n1996-08-30 O\n\nBelgrade B-LOC\n's O\nmain O\nairport O\nAerodrom B-LOC\nBeograd I-LOC\nwill O\nbe O\nclosed O\nto O\ntraffic O\nfor O\nrunway O\nmaintenance O\nand O\nmodernization O\nfrom O\nSeptember O\n21 O\nto O\n26 O\n, O\nthe O\nYugoslav B-MISC\nnews O\nagency O\nTanjug B-ORG\nreported O\nlate O\non O\nFriday O\n. O\n\n\" O\nDuring O\nthe O\nworks O\n, O\nall O\nflights O\nwill O\nbe O\nre-routed O\nto O\nthe O\nnearby O\nairport O\nin O\nBatajnica B-LOC\n, O\nwith O\nno O\nchange O\nin O\nschedules O\n, O\n\" O\nTanjug B-ORG\nquotes O\nBelgrade B-LOC\nairport O\nGeneral O\nDirector O\nLjubomir B-PER\nAcimovic I-PER\nas O\nsaying O\n. O\n\nThe O\nairport O\nin O\nSurcin B-LOC\nwill O\ncontinue O\nto O\ncarry O\nout O\nall O\nother O\nactivities O\nand O\nhas O\nsecured O\nenough O\nbuses O\nto O\ntransport O\npassengers O\nto O\nBatajnica B-LOC\n, O\nAcimovic B-PER\nsaid O\n. O\n\nThe O\nvalue O\nof O\nmaintenance O\nworks O\n, O\nwhich O\nwill O\nlast O\n120 O\nhours O\nstraight O\n, O\nis O\n20 O\nmillion O\ndinars O\nand O\nthe O\nfunds O\nhave O\nbeen O\nsecured O\nby O\nBelgrade B-LOC\nairport O\n, O\nTanjug B-ORG\nsaid O\n. O\n\nThe O\nBatajnica B-LOC\nairport O\nwill O\ntake O\nover O\ncomplete O\nair O\ntraffic O\ncontrol O\nduring O\nthis O\nperiod O\n, O\nFederal B-ORG\nAir I-ORG\nTraffic I-ORG\nControl I-ORG\nAdministration I-ORG\nDirector O\nBranko B-PER\nBilbija I-PER\nsaid O\n. O\n\n-- O\nAmra B-PER\nKevic I-PER\n, O\nBelgrade B-LOC\nnewsroom O\n+381 O\n11 O\n2224305 O\n\n-DOCSTART- O\n\nTop O\nBelarus B-LOC\npolitician O\nblasts O\npresident O\n. O\n\nLarisa B-PER\nSayenko I-PER\n\nMINSK B-LOC\n1996-08-30 O\n\nA O\nsenior O\nBelarus B-LOC\npolitician O\naccused O\nPresident O\nAlexander B-PER\nLukashenko I-PER\non O\nFriday O\nof O\nattempting O\nto O\nset O\nup O\na O\ndictatorship O\nin O\nthe O\nformer O\nSoviet B-MISC\nrepublic O\n. O\n\nThe O\nspeaker O\nof O\nthe O\nBelarus B-LOC\nparliament O\n, O\nSemyon B-PER\nSharetsky I-PER\n, O\ntold O\nReuters B-ORG\nthat O\na O\ndraft O\nconstitution O\n, O\ndue O\nto O\nbe O\nput O\nto O\na O\nnational O\nreferendum O\non O\nNovember O\n7 O\n, O\nwould O\ndangerously O\nincrease O\nthe O\npowers O\nof O\nthe O\nruler O\n. O\n\n\" O\nThe O\nworld O\ncommunity O\nshould O\nnot O\nbe O\nindifferent O\nto O\nthe O\nfact O\nthat O\nPresident O\nLukashenko B-PER\n, O\nwho O\nleads O\nthis O\nEuropean B-MISC\nstate O\nof O\n10 O\nmillion O\npeople O\n, O\nis O\ntrying O\nto O\nestablish O\na O\ndictatorship O\nwith O\nhis O\nnew O\nconstitution O\n, O\n\" O\nSharetsky B-PER\nsaid O\n. O\n\nThe O\nnew O\nconstitution O\ncalls O\nfor O\na O\ntwo-chamber O\nparliament O\nwith O\na O\n110-seat O\nmajority-elected O\nhouse O\nof O\nrepresentatives O\nand O\na O\nregionally-represented O\nsenate O\nwith O\na O\nthird O\nof O\nits O\nmembers O\nnamed O\nby O\nthe O\npresident O\n. O\n\nLukashenko B-PER\n's O\naides O\nshrugged O\noff O\nSharetsky B-PER\n's O\ncharge O\n. O\n\" O\n\nIf O\nthere O\nwas O\na O\ndictatorship O\nthey O\nwould O\nn't O\nhave O\nthe O\nright O\nto O\nsay O\nthings O\nlike O\nthis O\n, O\n\" O\nSergei B-PER\nPosukhov I-PER\n, O\nLukashenko B-PER\n's O\npolitical O\nadviser O\n, O\ntold O\nReuters B-ORG\n. O\n\n\" O\nThe O\npeople O\nhave O\nasked O\nus O\nto O\nestablish O\norder O\nand O\nthat O\n's O\nour O\nmain O\naim O\n. O\n\" O\n\nLukashenko B-PER\n, O\n41 O\n, O\nwon O\npresidential O\npolls O\nin O\n1994 O\non O\npromises O\nto O\nrestore O\norder O\n, O\nfight O\ncorruption O\nand O\nrepair O\nthe O\nstrong O\nlinks O\nwith O\nRussia B-LOC\nthat O\nwere O\ndisrupted O\nby O\nthe O\ncollapse O\nof O\nthe O\nSoviet B-LOC\nUnion I-LOC\n. O\n\nBut O\nduring O\nhis O\nperiod O\nin O\noffice O\nhe O\nhas O\nbattled O\nagainst O\nnationalist O\nopponents O\n, O\ntrade O\nunions O\nand O\nparliament O\nand O\nSharetsky B-PER\nsaid O\nthe O\ncurrent O\nparliament O\nwas O\nready O\nto O\ntry O\nto O\nimpeach O\nhim O\n. O\n\n\" O\nThis O\nconstitution O\n, O\nwhich O\nhas O\nbeen O\nprepared O\nin O\nsecret O\n, O\naims O\nto O\ngather O\nall O\npower O\nin O\none O\nman O\n's O\nhands O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nWe O\nshould O\nnot O\nbe O\nfooled O\nby O\nhis O\nquasi-democratic O\nrhetoric O\nand O\nhis O\nmethods O\n, O\nlike O\nthis O\nreferendum O\n. O\n\" O\n\nLukashenko B-PER\nsigned O\na O\npact O\nwith O\nMoscow B-LOC\nin O\nApril O\nto O\ncreate O\na O\nstrong O\neconomic O\nand O\npolitical O\nunion O\nwhich O\nhe O\nbelieves O\ncould O\ngrow O\ninto O\na O\nfederation O\n. O\n\nBut O\nnationalist O\ngroups O\n, O\nscared O\nby O\nthe O\nprospect O\nof O\nrenewed O\nMoscow B-LOC\ndomination O\nand O\nRussia B-LOC\n's O\nbacking O\nfor O\nLukashenko B-PER\n, O\nprotested O\nagainst O\nthe O\ndeal O\n. O\n\nLukashenko B-PER\nresponded O\nby O\ncracking O\ndown O\non O\nthe O\nnationalist O\nopposition O\nand O\njailing O\nnearly O\n200 O\npeople O\nfor O\ntaking O\npart O\nin O\ndemonstrations O\nagainst O\nthe O\npact O\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\nlast O\nweek O\ngranted O\npolitical O\nasylum O\nto O\ntwo O\nopposition O\nleaders O\n, O\nZenon B-PER\nPoznyak I-PER\nand O\nSergei B-PER\nNaumchik I-PER\n. O\n\n-DOCSTART- O\n\nTajik B-MISC\ntroops O\nnow O\ncontrol O\ndevastated O\ntown O\n. O\n\nYuri B-PER\nKushko I-PER\n\nTAVILDARA B-LOC\n, O\nTajikistan B-LOC\n1996-08-30 O\n\nTajik B-MISC\ngovernment O\ntroops O\nnow O\ncontrol O\nof O\nthe O\nstrategically O\nvital O\ntown O\nof O\nTavildara B-LOC\nafter O\ndriving O\nout O\nIslamic B-MISC\nrebels O\n, O\nbut O\nsporadic O\ngunfire O\nstill O\nechoed O\nin O\nthe O\nnearby O\nPamir B-LOC\nmountains O\non O\nFriday O\n. O\n\nThe O\ncommander-in-chief O\nof O\nTajikistan B-LOC\n's O\narmed O\nforces O\n, O\nMajor-General O\nNikolai B-PER\nSherbatov I-PER\n, O\ntook O\na O\ngroup O\nof O\njournalists O\nby O\nhelicopter O\nto O\nthe O\nremote O\n, O\nand O\nnow O\ndevastated O\n, O\ntown O\nto O\nshow O\nthat O\nhis O\nforces O\nheld O\nit O\n. O\n\nHe O\nsaid O\nhis O\ntroops O\ntook O\nTavildara B-LOC\nwithout O\ncasualties O\non O\nAugust O\n23 O\n, O\nbut O\nthe O\ncrack O\nof O\nsniper O\nand O\nmachinegun O\nfire O\nrevealed O\nthe O\npresence O\nof O\nopposition O\nfighters O\nin O\nthe O\nsurrounding O\nmountains O\n. O\n\nSherbatov B-PER\nsaid O\nthe O\nrebels O\nwere O\nlocated O\nabout O\nthree O\nkm O\n( O\ntwo O\nmiles O\n) O\neast O\nof O\nTavildara B-LOC\naround O\nthe O\nvillage O\nof O\nLayron B-LOC\n. O\n\nTavildara B-LOC\n, O\n200 O\nkm O\n( O\n120 O\nmiles O\n) O\neast O\nof O\nthe O\ncapital O\nDushanbe B-LOC\n, O\nwas O\nin O\nruins O\n. O\n\nShells O\nhad O\nsmashed O\nroofs O\nand O\nwindows O\nand O\nempty O\nshell O\ncases O\nlittered O\nthe O\nstreets O\n. O\n\nThe O\ntown O\nstraddles O\na O\nstrategically O\nimportant O\nroad O\nlinking O\ngovernment O\nand O\nrebel-held O\nterritory O\nand O\nhas O\nfallen O\nsuccesively O\nto O\nboth O\nsides O\nin O\na O\nbloody O\ntug-of-war O\nwhich O\nbegan O\nlast O\nFebruary O\n. O\n\nTajikistan B-LOC\n, O\nwhich O\nborders O\nAfghanistan B-LOC\nand O\nChina B-LOC\n, O\nhas O\nbeen O\nsplit O\nby O\na O\ndragging O\nfour-year O\nconflict O\nafter O\na O\ncivil O\nwar O\nbetween O\ncommunists O\nand O\na O\nfrail O\ncoalition O\nof O\nIslamic B-MISC\nand O\nliberal O\ngroups O\n. O\n\nTens O\nof O\nthousands O\nof O\npeople O\nhave O\nbeen O\nkilled O\nand O\nmany O\nmore O\nhave O\nbeen O\ndisplaced O\nin O\nthe O\nfighting O\n, O\nwhich O\nbreached O\na O\nshaky O\nUnited B-MISC\nNations-sponsored I-MISC\nceasefire O\n. O\n\nTavildara B-LOC\nis O\nnow O\napparently O\ninhabited O\nonly O\nby O\na O\nfew O\nold O\nmen O\n, O\nwomen O\nand O\ntheir O\ngrubby O\n, O\nbarefoot O\nchildren O\n. O\n\nFruit O\nremained O\non O\nthe O\ntrees O\nas O\nthere O\nwas O\nno O\none O\nto O\npick O\nit O\n. O\n\n\" O\nHelp O\nme O\n, O\nhelp O\nme O\n, O\n\" O\nsaid O\na O\nchorus O\nof O\nwomen O\nbegging O\nsoldiers O\nfor O\nfood O\n. O\n\nThe O\ntown O\n's O\nschool O\nand O\na O\nshop O\ndoubling O\nas O\na O\nwarehouse O\nfor O\nhumanitarian O\naid O\nwere O\ndestroyed O\nin O\nthe O\nfighting O\n. O\n\n\" O\nWe O\nhad O\nto O\nbuild O\nour O\nown O\nearth O\nshelters O\nto O\nsurvive O\nthe O\nfighting O\n, O\n\" O\nsaid O\nRajab B-PER\nAdinayev I-PER\n, O\na O\nbearded O\nelderly O\nTajik B-MISC\nin O\na O\nlong O\nwhite O\nshirt O\n. O\n\nAlthough O\nshy O\nin O\nfront O\nof O\nthe O\ngovernment O\nsoldiers O\n, O\nseveral O\ninhabitants O\naccused O\ngovernment O\nforces O\nof O\nwidespread O\nlooting O\nof O\nhomes O\nand O\nlivestock O\n. O\n\nThey O\nalso O\nsaid O\nrebel O\nfighters O\nhad O\nlooted O\nmedicines O\nfrom O\nthe O\nlocal O\nhospital O\n. O\n\nOne O\nelderly O\nman O\n, O\nwho O\ndeclined O\nto O\ngive O\nhis O\nname O\n, O\nsaid O\ntwo O\nof O\nhis O\nsons O\nwere O\nnow O\nrefugees O\nin O\nMoscow B-LOC\nand O\nthe O\nother O\ntwo O\nhad O\nleft O\nto O\nfight O\nfor O\nthe O\nopposition O\n. O\n\nHe O\nalso O\nsaid O\ngovernment O\nsoldiers O\nhad O\nraped O\nthe O\nwife O\nof O\none O\nof O\nhis O\nsons O\n. O\n\" O\n\nIt O\n's O\nnot O\nimportant O\nwho O\nholds O\nthis O\ntown O\n, O\nwe O\njust O\nneed O\nto O\nstop O\nthe O\nwar O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nPolish B-MISC\nForeign O\nMinister O\nto O\nvisit O\nYugoslavia B-LOC\n. O\n\nWARSAW B-LOC\n1996-08-30 O\n\nPoland B-LOC\n's O\nForeign O\nMinister O\nDariusz B-PER\nRosati I-PER\nwill O\nvisit O\nYugoslavia B-LOC\non O\nSeptember O\n3 O\nand O\n4 O\nto O\nrevive O\na O\ndialogue O\nbetween O\nthe O\ntwo O\ngovernments O\nwhich O\nwas O\neffectively O\nfrozen O\nin O\n1992 O\n, O\nPAP B-ORG\nnews O\nagency O\nreported O\non O\nFriday O\n. O\n\nDuring O\nRosati B-PER\n's O\ntrip O\nthe O\ntwo O\ncountries O\nwill O\nsign O\nan O\nagreement O\non O\nmutual O\nprotection O\nof O\ninvestments O\nand O\na O\nnote O\neasing O\nconditions O\non O\nthe O\ngranting O\nof O\nvisas O\n, O\nthe O\nagency O\nquoted O\nForeign B-ORG\nMinistry I-ORG\nofficials O\nas O\nsaying O\n. O\n\nThe O\nFederal B-LOC\nRepublic I-LOC\nof I-LOC\nYugoslavia I-LOC\nis O\nthe O\nonly O\ncountry O\nof O\nthe O\nformer O\nYugoslavia B-LOC\nwhere O\nPoles B-MISC\ncurrently O\nrequire O\nvisas O\n. O\n\nThey O\nare O\nalso O\nto O\nclinch O\nprotocols O\non O\nculture O\nand O\nunderstanding O\nbetween O\nthe O\ntwo O\nforeign O\nministries O\n. O\n\nRosati B-PER\nwill O\nmeet O\nSerbian B-MISC\nPresident O\nSlobodan B-PER\nMilosevic I-PER\nand O\nYugoslav B-MISC\npoliticians O\nin O\nBelgrade B-LOC\n, O\nbefore O\nvisiting O\nMontenegro B-LOC\n. O\n\nPoland B-LOC\nrevived O\ndiplomatic O\nties O\nat O\nambassadorial O\nlevel O\nwith O\nYugoslavia B-LOC\nin O\nApril O\nbut O\neconomic O\nlinks O\nare O\nalmost O\nmoribund O\n, O\ndespite O\nthe O\nend O\nof O\na O\nthree-year O\nU.N. B-ORG\ntrade O\nembargo O\nimposed O\nto O\npunish O\nBelgrade B-LOC\nfor O\nits O\nsupport O\nof O\nBosnian B-MISC\nSerbs I-MISC\n. O\n\nPoland B-LOC\nis O\nseeking O\npacts O\non O\navoiding O\ndouble O\ntaxation O\nand O\nwants O\ncooperation O\nin O\nfighting O\ncrime O\n. O\n\n-DOCSTART- O\n\nYeltsin B-PER\nvisits O\nwife O\nNaina B-PER\nin O\nhospital O\n- O\nInterfax B-ORG\n. O\n\nMOSCOW B-LOC\n1996-08-30 O\n\nRussian B-MISC\nPresident O\nBoris B-PER\nYeltsin I-PER\nvisited O\nhis O\nwife O\nNaina B-PER\nin O\nhospital O\non O\nFriday O\nevening O\n, O\nInterfax B-ORG\nnews O\nagency O\nquoted O\nspokesman O\nSergei B-PER\nYastrzhembsky I-PER\nas O\nsaying O\n. O\n\nNaina B-PER\nYeltsin I-PER\nhad O\na O\nkidney O\noperation O\nlast O\nSaturday O\n. O\n\nEarlier O\nRussian B-MISC\nnews O\nreports O\nhad O\nsaid O\nYeltsin B-PER\n's O\nchildren O\nand O\ngrandchildren O\nhad O\nvisited O\nthe O\nRussian B-MISC\nfirst O\nlady O\nbut O\nthey O\nsaid O\nonly O\nthat O\nYeltsin B-PER\n, O\non O\nvacation O\noutside O\nMoscow B-LOC\n, O\nhad O\nspoken O\nto O\nher O\nby O\ntelephone O\n. O\n\n\" O\nNaina B-PER\nYeltsin I-PER\nlooks O\nwell O\n, O\nshe O\nis O\nactive O\n, O\nshe O\nis O\nclearly O\ngetting O\nbetter O\n, O\n\" O\nYastrzhembsky B-PER\nquoted O\nYeltsin B-PER\nas O\nsaying O\n. O\n\nNaina B-PER\nYeltsin I-PER\nis O\nrecovering O\nin O\nMoscow B-LOC\n's O\nCentral B-LOC\nClinical I-LOC\nHospital I-LOC\n, O\nwhere O\nthe O\npresident O\nhimself O\nwas O\ntreated O\ntwice O\nlast O\nyear O\nfor O\nheart O\nattacks O\n. O\n\nYeltsin B-PER\n, O\n65 O\n, O\nhas O\nbeen O\nseen O\nonly O\nrarely O\nsince O\nhe O\nwas O\nelected O\nfor O\na O\nsecond O\nterm O\nin O\noffice O\non O\nJuly O\n3 O\n, O\nalthough O\nhis O\naides O\nhave O\ndenied O\na O\nstring O\nof O\nrumours O\nthat O\nhe O\nhas O\nbeen O\ntaken O\nill O\nagain O\n. O\n\nYastrzhembsky B-PER\nsaid O\nYeltsin B-PER\nhad O\ntravelled O\nfrom O\nthe O\nhospital O\nto O\nspend O\nthe O\nnight O\nat O\nthe O\nBarvikha B-LOC\nsanatorium O\noutside O\nMoscow B-LOC\n. O\n\nHe O\nwas O\nlikely O\nto O\nreturn O\non O\nSaturday O\nto O\nhis O\nholiday O\nresort O\n, O\na O\nhunting O\nlodge O\nsome O\n100 O\nkm O\n( O\n60 O\nmiles O\n) O\nfrom O\nMoscow B-LOC\n. O\n\n-DOCSTART- O\n\nLebed B-PER\n, O\nChechens B-MISC\nstart O\npeace O\ntalks O\n. O\n\nKHASAVYURT B-LOC\n, O\nRussia B-LOC\n1996-08-30 O\n\nRussian B-MISC\npeacemaker O\nAlexander B-PER\nLebed I-PER\nand O\nChechen B-MISC\nseparatist O\nmilitary O\nleader O\nAslan B-PER\nMaskhadov I-PER\nstarted O\na O\nnew O\nround O\nof O\npeace O\ntalks O\non O\nFriday O\nin O\nthis O\nsettlement O\njust O\noutside O\nthe O\nrebel O\nregion O\n. O\n\nLebed B-PER\n, O\nwho O\nflew O\ninto O\nChechnya B-LOC\nearlier O\nin O\nthe O\nday O\n, O\nsaid O\nhe O\nhoped O\nto O\nsign O\na O\nframework O\nagreement O\non O\na O\npolitical O\nsettlement O\nof O\nthe O\n20-month O\nconflict O\nin O\nwhich O\ntens O\nof O\nthousands O\nof O\npeople O\nhave O\ndied O\n. O\n\nNeither O\nLebed B-PER\nnor O\nMaskhadov B-PER\nmade O\nany O\nstatement O\nbefore O\nthe O\ntalks O\n. O\n\n-DOCSTART- O\n\nRussian B-MISC\njudge O\nstabbed O\nto O\ndeath O\nover O\n$ O\n7 O\nfine O\n. O\n\nMOSCOW B-LOC\n1996-08-30 O\n\nA O\nMoscow B-LOC\nstreet O\nvendor O\nstabbed O\nto O\ndeath O\na O\nwoman O\njudge O\nin O\na O\ncity O\ncourt O\non O\nFriday O\nafter O\nshe O\nfined O\nhim O\nthe O\nequivalent O\nof O\nseven O\ndollars O\nfor O\ntrading O\nillegally O\n, O\nInterfax B-ORG\nnews O\nagency O\nsaid O\n. O\n\nInterfax B-ORG\nsaid O\nJudge O\nOlga B-PER\nLavrentyeva I-PER\n, O\n28 O\n, O\non O\nThursday O\nordered O\nthe O\nconfiscation O\nof O\nseveral O\novercoats O\n, O\nsuits O\nand O\nshirts O\nwhich O\nvendor O\nValery B-PER\nIvankov I-PER\n, O\n41 O\n, O\nwas O\nillegally O\ntrading O\non O\nMoscow B-LOC\nstreets O\nand O\nfined O\nhim O\n38,000 O\nroubles O\n( O\nseven O\ndollars O\n) O\n. O\n\nThe O\nnext O\nmorning O\n, O\nIvankov B-PER\nappeared O\nin O\nthe O\ncourtroom O\nand O\nstabbed O\nLavrentyeva B-PER\n. O\n\nThe O\njudge O\ndied O\nlater O\nin O\nhospital O\n. O\n\nInterfax B-ORG\nquoted O\nLevrentyeva B-PER\n's O\ncolleagues O\nas O\nsaying O\nthat O\njudges O\nwere O\ngenerally O\nunprotected O\nagainst O\ncriminal O\nattacks O\n. O\n\n-DOCSTART- O\n\nCofinec B-ORG\nplunges O\non O\nH1 O\nresults O\n. O\n\nEmese B-PER\nBartha I-PER\n\nBUDAPEST B-LOC\n1996-08-30 O\n\nShares O\nof O\nFrance-registered B-MISC\nprinted O\npackaging O\ncompany O\nCofinec B-ORG\nS.A. I-ORG\nplunged O\nsharply O\non O\nthe O\nBudapest B-ORG\nStock I-ORG\nExchange I-ORG\n( O\nBSE B-ORG\n) O\non O\nFriday O\n, O\ndespite O\na O\nmostly O\nreassuring O\nforecast O\nby O\nthe O\ngroup O\n. O\n\nCofinec B-ORG\n's O\nGlobal O\nDepositary O\nReceipts O\n( O\nGDRs O\n) O\nopened O\nat O\n5,200 O\nforints O\non O\nthe O\nBSE B-MISC\n, O\ndown O\n600 O\nfrom O\nThursday O\n's O\nclose O\n, O\nfollowing O\nthe O\nrelease O\nof O\nits O\nfirst O\nhalf O\nresults O\nthis O\nmorning O\n. O\n\nCofinec B-ORG\nCEO O\nStephen B-PER\nFrater I-PER\ntold O\nreporters O\nin O\na O\nconference O\ncall O\nfrom O\nVienna B-LOC\non O\nFriday O\nbefore O\nthe O\nopening O\nof O\nthe O\nbourse O\nthat O\nhe O\nexpects O\na O\nstronger O\nsecond O\nhalf O\n, O\nalthough O\nthe O\ngroup O\nwill O\nnot O\nbe O\nable O\nto O\nachieve O\nits O\nannual O\nprofit O\ngoal O\n. O\n\n\" O\nWe O\nwill O\nnot O\nachieve O\nthe O\nfull O\n37 O\nmillion O\nFrench B-MISC\nfranc O\n( O\nnet O\n) O\nprofit O\nforecast O\n, O\n\" O\nFrater B-PER\nsaid O\n. O\n\" O\n\nObviously O\n, O\nwe O\ncannot O\nmake O\nup O\nthe O\nunexpected O\ndecrease O\nthat O\nhas O\nbeen O\nexperienced O\nin O\nthe O\nfirst O\nhalf O\nof O\nthe O\nyear O\n. O\n\" O\n\nFrater B-PER\ndeclined O\nto O\ngive O\na O\nforecast O\nfor O\nthe O\nfull O\nyear O\n, O\nahead O\nof O\na O\nsupervisory O\nboard O\nmeeting O\nnext O\nweek O\n. O\n\nCofinec B-ORG\n, O\nthe O\nfirst O\nforeign O\ncompany O\nto O\nlist O\non O\nthe O\nBudapest B-LOC\nbourse O\n, O\nreleased O\nits O\nconsolidated O\nfirst O\nhalf O\nfigures O\n( O\nIAS O\n) O\nthis O\nmorning O\n. O\n\nIn O\nthe O\nconference O\ncall O\n, O\nFrater B-PER\nsaid O\nhe O\nregarded O\nCofinec B-ORG\nGDRs O\n-- O\nwhich O\nare O\ntrading O\nbelow O\ntheir O\nissue O\nprice O\nof O\n6,425 O\nforints O\n-- O\nas O\na O\nbuying O\nopportunity O\n. O\n\n\" O\nObviously O\n, O\nat O\nsome O\npoint O\nit O\nrepresents O\na O\nbuying O\nopportunity O\n, O\n\" O\nFrater B-PER\nsaid O\n. O\n\" O\n\nI O\nthink O\nthe O\nreality O\nis O\nthat O\nwe O\noperate O\nin O\nemerging O\nmarkets O\n, O\nemerging O\nmarkets O\ntend O\nto O\nbe O\nmore O\nvolatile O\n. O\n\" O\n\n\" O\nMy O\nmessage O\nis O\nthat O\nthe O\nfundamental O\nstrategy O\nof O\nthe O\ncompany O\n, O\nits O\nfundamental O\nmarket O\nposition O\nhas O\nnot O\nchanged O\n. O\n\" O\n\nThe O\ngroup O\n, O\nwhich O\noperates O\nin O\nHungary B-LOC\n, O\nPoland B-LOC\nand O\nthe O\nCzech B-LOC\nRepublic I-LOC\n, O\nreported O\nan O\noperating O\nprofit O\nbefore O\ninterest O\nof O\n21.8 O\nmillion O\nFrench B-MISC\nfrancs O\ncompared O\nto O\n34.1 O\nmillion O\nin O\nthe O\nsame O\nsix O\nmonths O\nof O\n1995 O\n. O\n\nNet O\nprofit O\nfor O\nthe O\nJanuary-June O\n1996 O\nperiod O\nwas O\n2.1 O\nmillion O\nFrench B-MISC\nfrancs O\n, O\ndown O\nfrom O\n10.3 O\nmillion O\nin O\nthe O\nfirst O\nsix O\nmonths O\nof O\n1995 O\n, O\nwith O\nthe O\nbulk O\nof O\nthis O\ndecline O\nattributable O\nto O\nthe O\nperformance O\nof O\nPetofi B-ORG\n, O\none O\nof O\nits O\nHungarian B-MISC\nunits O\n. O\n\nCofinec B-ORG\nsaid O\nPetofi B-ORG\ngeneral O\nmanager O\nLaszlo B-PER\nSebesvari I-PER\nhad O\nsubmitted O\nhis O\nresignation O\nand O\nwill O\nbe O\nleaving O\nPetofi B-ORG\nbut O\nwill O\nremain O\non O\nPetofi B-ORG\n's O\nboard O\nof O\ndirectors O\n. O\n\n\" O\nUntil O\na O\nnew O\ngeneral O\nmanager O\nof O\nPetofi B-ORG\nis O\nappointed O\n... O\n\nI O\nwill O\nin O\nfact O\nmove O\nto O\nKecskemet B-LOC\n( O\nsite O\nof O\nPetofi B-ORG\nprinting O\nhouse O\n) O\nfor O\nthe O\ninterim O\nand O\nwill O\nserve O\nas O\nacting O\nchief O\nexecutive O\nofficer O\nof O\nPetofi B-ORG\n, O\n\" O\nFrater B-PER\nsaid O\n. O\n\n-- O\nBudapest B-LOC\nnewsroom O\n( O\n36 O\n1 O\n) O\n327 O\n4040 O\n\n-DOCSTART- O\n\nRomania B-LOC\ncen O\nbank O\none-week O\nrate O\nrises O\nto O\n50.19 O\npct O\n. O\n\nBUCHAREST B-LOC\n1996-08-30 O\n\nThe O\nNational B-ORG\nBank I-ORG\nof I-ORG\nRomania I-ORG\n( O\nBNR B-ORG\n) O\nsaid O\nits O\none-week O\nrefinancing O\nrate O\nhas O\nbeen O\nlifted O\nthis O\nweek O\nto O\n50.19 O\npercent O\nfrom O\n49 O\npercent O\nafter O\ntwo O\nbanks O\nbids O\n' O\nexceeded O\nits O\noffer O\nat O\nThursday O\n's O\nauction O\n. O\n\nThe O\ntwo O\nbanks O\nentered O\nbids O\ntotalling O\n497.5 O\nbillion O\nlei O\nat O\nrates O\nranging O\nfrom O\n49 O\nto O\n51 O\npercent O\n, O\nagainst O\nthe O\nBNR B-ORG\n's O\noffer O\nof O\n420 O\nbillion O\nlei O\n. O\n\nTraders O\nsaid O\nthat O\nover O\nthe O\npast O\nfew O\ndays O\nthe O\ntwo O\nmajor O\nbanks O\n, O\nkeen O\nto O\nmeet O\nminimum O\nreserve O\ntargets O\n, O\nalso O\nchased O\nfunds O\non O\nthe O\nmoney O\nmarket O\n, O\nbeing O\nready O\nto O\ngulp O\nshort-term O\nmoney O\nat O\nrates O\nup O\nto O\n49 O\npercent O\n. O\n\nOther O\nbanks O\ntraded O\none-week O\nrates O\nnear O\n48 O\npercent O\n. O\n\n-- O\nBucharest B-ORG\nNewsroom I-ORG\n40-1 O\n3120264 O\n\n-DOCSTART- O\n\nPotent O\nlandmines O\nfound O\nnear O\nColombian B-MISC\npresidency O\n. O\n\nBOGOTA B-LOC\n, O\nColombia B-LOC\n1996-08-30 O\n\nEight O\nclaymore O\nmines O\nfitted O\nwith O\npowerful O\nC-4 O\nplastic O\nexplosives O\nwere O\nfound O\nstashed O\nin O\na O\nreal O\nestate O\noffice O\non O\nFriday O\nlocated O\nabout O\ntwo O\nblocks O\nfrom O\nColombia B-LOC\n's O\npresidential O\npalace O\n, O\npolice O\nsaid O\n. O\n\n\" O\nThese O\nare O\npowerful O\nweapons O\n, O\n\" O\na O\nspokesman O\nwith O\nthe O\nMunicipal B-ORG\nPolice I-ORG\ntold O\nReuters B-ORG\nby O\ntelephone O\n, O\nadding O\nthat O\npolice O\nhad O\nnot O\nruled O\nout O\na O\npossible O\nterrorist O\nattack O\non O\nthe O\nornate O\nCasa B-LOC\nde I-LOC\nNarino I-LOC\npresidential O\npalace O\nin O\nBogota B-LOC\n's O\nhistoric O\ndowntown O\narea O\n. O\n\n\" O\nThey O\ncould O\ncause O\nserious O\ndamage O\nas O\nmuch O\nas O\n500 O\nmeters O\n( O\nyards O\n) O\naway O\nfrom O\nwherever O\nthey O\nwere O\ndetonated O\n, O\n\" O\nthe O\nspokesman O\nadded O\n. O\n\nHe O\nsaid O\npolice O\nbacked O\nby O\nexplosive O\nexperts O\nwere O\ncombing O\nthe O\narea O\nin O\nsearch O\nof O\nother O\npossible O\nweapons O\nor O\nexplosive O\ndevices O\n. O\n\nThe O\npolice O\nspokeman O\nsaid O\nplastic O\nexplosive O\nlike O\nC-4 O\nis O\nnot O\na O\nnormal O\ncomponent O\nin O\nclaymore O\nmines O\n. O\n\nBut O\nhe O\nsaid O\nthe O\neight O\nmines O\nseized O\nby O\npolice O\nhad O\nbeen O\n\" O\nspecially O\nadapted O\n. O\n\" O\n\nThe O\nspokesman O\ndeclined O\nfurther O\ncomment O\n, O\nexcept O\nto O\nsay O\nthat O\ntwo O\nwomen O\nand O\na O\nman O\nidentified O\nas O\na O\nlawyer O\nhad O\nbeen O\narrested O\nin O\nconnection O\nwith O\nthe O\nlandmines O\n. O\n\n-DOCSTART- O\n\nAssault O\ncharges O\ndropped O\nagainst O\nSurinam B-LOC\nex-rebel O\n. O\n\nPARAMARIBO B-LOC\n, O\nSurinam B-LOC\n1996-08-30 O\n\nFlamboyant O\nformer O\nSurinamese B-MISC\nguerrilla O\nleader O\nRonny B-PER\nBrunswijk I-PER\nwalked O\nfree O\non O\nFriday O\nafter O\ncharges O\nof O\nattempted O\nmurder O\nwere O\ndropped O\n, O\npolice O\nsaid O\n. O\n\nBrunswijk B-PER\nhad O\nbeen O\nin O\npolice O\ncustody O\nfor O\n10 O\ndays O\nafter O\nFreddy B-PER\nPinas I-PER\n, O\na O\nSurinamese-born B-MISC\nvisitor O\nfrom O\nthe O\nNetherlands B-LOC\n, O\naccused O\nBrunswijk B-PER\nof O\ntrying O\nto O\nkill O\nhim O\nin O\na O\nbar-room O\nbrawl O\nin O\nthe O\nmining O\ntown O\nof O\nMoengo B-LOC\n56 O\nmiles O\n( O\n90 O\nkm O\n) O\neast O\nof O\nParamaribo B-LOC\n. O\n\nBrunswijk B-PER\n, O\n35 O\n, O\ndenied O\nthe O\ncharge O\nand O\nreached O\nan O\nagreement O\nwith O\nPinas B-PER\nafter O\nreplacing O\na O\ngolden O\nnecklace O\nlost O\nin O\nthe O\nscuffle O\n. O\n\nIt O\nwas O\nthe O\nsecond O\ntime O\nBrunswijk B-PER\nhad O\nbeen O\ncharged O\nwith O\nattempted O\nmurder O\nin O\nless O\nthan O\ntwo O\nyears O\n. O\n\nIn O\n1994 O\nhe O\nserved O\ntwo O\nmonths O\nfor O\nshooting O\na O\nthief O\nin O\nthe O\nbackside O\n. O\n\nBrunswijk B-PER\n, O\nwho O\nled O\na O\nrebel O\ngroup O\nagainst O\nthe O\nmilitary O\nregime O\nof O\nDesi B-PER\nBouterse I-PER\nin O\nthe O\nlate O\n1980s O\n, O\nis O\nnow O\na O\nsuccessful O\nbusinessman O\nwith O\nmining O\nand O\nlogging O\ninterests O\n. O\n\n-DOCSTART- O\n\nCambodian B-MISC\nopposition O\nnewspaper O\neditor O\npardoned O\n. O\n\nPHNOM B-LOC\nPENH I-LOC\n1996-08-30 O\n\nCambodia B-LOC\n's O\nKing O\nNorodom B-PER\nSihanouk I-PER\non O\nFriday O\ngave O\na O\nroyal O\npardon O\nto O\nan O\nopposition O\nnewspaper O\neditor O\nwho O\nhad O\nalleged O\ntop-level O\ncorruption O\n. O\n\nHen B-PER\nVipheak I-PER\n, O\nformer O\neditor O\nof O\nthe O\nSereipheap B-ORG\nThmei I-ORG\n( O\nNew B-ORG\nLiberty I-ORG\n) O\nnewspaper O\n, O\nstepped O\nthrough O\nthe O\ngates O\nof O\nthe O\nrun-down O\nFrench B-MISC\ncolonial-era O\nT3 B-LOC\nprison O\nlate O\nFriday O\nafternoon O\n, O\nfollowing O\nintervention O\non O\nhis O\nbehalf O\nby O\nKing O\nSihanouk B-PER\n. O\n\nThe O\nSupreme B-ORG\nCourt I-ORG\nhad O\non O\nAugust O\n23 O\nsent O\nthe O\nopposition O\nKhmer B-ORG\nNation I-ORG\nParty I-ORG\nsteering O\ncommittee O\nmember O\nto O\njail O\nafter O\nupholding O\nrulings O\nby O\nthe O\nmunicipal O\nand O\nappeal O\ncourts O\nthat O\nhanded O\ndown O\na O\nfive O\nmillion O\nriels O\n( O\n$ O\n2,000 O\n) O\nfine O\nand O\none O\nyear O\n's O\nimprisonment O\n. O\n\nThe O\njudge O\noverturned O\na O\ndecision O\nto O\nshut O\ndown O\nHen B-PER\nVipheak I-PER\n's O\nnewspaper O\n. O\n\nThe O\neditor O\nwas O\nprosecuted O\nfollowing O\na O\nMay O\n1995 O\narticle O\nalleging O\ntop-level O\ncorruption O\n. O\n\nSihanouk B-PER\npromised O\nan O\namnesty O\nto O\nHen B-PER\nVipheak I-PER\n, O\nalong O\nwith O\nfellow O\nKNP B-ORG\nmember O\nand O\njournalist O\nChan B-PER\nRattana I-PER\n, O\nwho O\nwas O\nreleased O\nafter O\nserving O\na O\nweek O\nof O\na O\nyear-long O\njail O\nterm O\nin O\nJune O\n. O\n\nCo-Premiers O\nPrince O\nNorodom B-PER\nRanariddh I-PER\nand O\nHun B-PER\nSen I-PER\nagreed O\nearlier O\nthis O\nweek O\nto O\nthe O\nking O\n's O\nrequest O\nfor O\nan O\namnesty O\n. O\n\n-DOCSTART- O\n\nFar B-LOC\nEast I-LOC\nGold O\n- O\nMoribund O\nmarket O\nseen O\ncontinuing O\n. O\n\nMishi B-PER\nSaran I-PER\n\nHONG B-LOC\nKONG I-LOC\n1996-08-30 O\n\nFar B-LOC\nEast I-LOC\ngold O\ntraders O\nthumped O\nforeheads O\nin O\nfrustration O\nat O\nthe O\nmarket O\n's O\nfoot-dragging O\nthis O\nweek O\nand O\nforecast O\non O\nFriday O\nthat O\nnext O\nweek O\nwould O\nnot O\nbe O\nmuch O\nbetter O\n. O\n\nThe O\nSoutheast B-MISC\nAsian I-MISC\ngold O\nmarket O\nwas O\nmore O\nor O\nless O\na O\nphoto-fit O\npicture O\nof O\nthe O\nprevious O\nweek O\n's O\nposition O\nwith O\nactivity O\nslow O\nand O\nbullion O\nprices O\ntrapped O\nin O\na O\nwell-worn O\nrange O\nawaiting O\na O\nseasonal O\nupturn O\nin O\ndemand O\nand O\nprices O\ninto O\nthe O\nfourth O\nquarter O\n. O\n\nSingapore B-LOC\npremiums O\nfor O\nAustralian B-MISC\nkilo O\nbars O\nwere O\nquoted O\nunchanged O\nat O\nbetween O\n25-45 O\ncents O\nan O\nounce O\nover O\nspot O\nloco O\nLondon B-LOC\nprices O\n, O\nwith O\nSouth B-MISC\nKorean I-MISC\nand O\nIndonesian-origin B-MISC\npremiums O\nalso O\nsteady O\nat O\n10-20 O\ncents O\nan O\nounce O\n. O\n\nSingapore B-LOC\ndealers O\nsaid O\nthey O\nwere O\nconcerned O\nthat O\nthere O\nhad O\nbeen O\na O\nmarked O\nrevival O\nin O\noffers O\nto O\nsell O\ngold O\nby O\nSouth B-MISC\nKorean I-MISC\ntraders O\n, O\nfollowing O\nthe O\ndistress O\nsales O\nof O\nrecent O\nmonths O\nafter O\nthe O\nSeoul B-LOC\ngovernment O\n's O\ncrackdown O\non O\nbullion O\narbitrage O\ntrade O\n. O\n\n\" O\nI O\nwas O\nshocked O\nto O\nsee O\nthese O\noffers O\ncoming O\nin O\nagain O\n, O\nthough O\nthere O\n's O\nbeen O\nno O\nindication O\nof O\nprice O\nor O\nvolume O\n. O\n\nI O\ndread O\nto O\nthink O\nwhat O\nwill O\nhappen O\nto O\nthe O\npremiums O\nif O\nthe O\nKoreans B-MISC\nstart O\nselling O\nin O\nforce O\n, O\n\" O\none O\ndealer O\nsaid O\n. O\n\nContinued O\ndishoarding O\nof O\nkilo-bars O\nby O\nIndonesian B-MISC\nsources O\nahead O\nof O\nnext O\nyear O\n's O\npresidential O\nelection O\nhas O\nalso O\nkept O\na O\nlid O\non O\npremiums O\n. O\n\nGold O\nclosed O\ndown O\nat O\n$ O\n387.00 O\n/ O\n$ O\n387.50 O\nan O\nounce O\nin O\nHong B-LOC\nKong I-LOC\non O\nFriday O\n, O\nversus O\nNew B-LOC\nYork I-LOC\n's O\n$ O\n387.60 O\n/ O\n$ O\n388 O\nfinish O\non O\nThursday O\n. O\n\nDealers O\nsaid O\nthe O\nprecious O\nmetal O\neased O\non O\na O\nreport O\nthat O\nthe O\nInternational B-ORG\nMonetary I-ORG\nFund I-ORG\nmight O\nsell O\nsome O\nof O\nits O\ngold O\nto O\nreduce O\nthe O\ndebts O\nof O\nthe O\npoorest O\ndeveloping O\ncountries O\n. O\n\nEasier O\nsilver O\nprices O\nmid-week O\nhelped O\nkeep O\nspot O\ngold O\nlocked O\nin O\na O\n$ O\n386 O\n- O\n$ O\n389 O\nan O\nounce O\nrange O\n, O\ndealers O\nsaid O\n, O\nbut O\nthey O\nremained O\noptimistic O\nthat O\nthe O\nusual O\nseasonal O\npick-up O\nin O\njewellery O\nfabrication O\ndemand O\nwould O\nsee O\ngold O\nat O\n$ O\n395 O\nby O\nend-October O\n. O\n\n\" O\nI O\nstill O\nthink O\nwe O\n'll O\nsee O\ngold O\nat O\n$ O\n395 O\nby O\nthe O\nend O\nof O\nOctober O\n, O\nin O\na O\nretracement O\nof O\nthe O\n$ O\n418 O\n- O\n$ O\n380 O\nmove O\nwe O\nsaw O\nat O\nthe O\nstart O\nof O\nthe O\nyear O\n, O\n\" O\none O\nsaid O\n. O\n\nSilver O\n, O\nbasis O\nthe O\nSeptember O\ncontract O\non O\nNew B-LOC\nYork I-LOC\n's O\nComex O\nmarket O\n, O\nwas O\nexpected O\nto O\nfind O\nsupport O\nat O\nbetween O\n$ O\n5.12 O\n- O\n$ O\n5.15 O\nan O\nounce O\nand O\nmeet O\nresistance O\nfrom O\n$ O\n5.25 O\n- O\n$ O\n5.30 O\n, O\nthey O\nadded O\n. O\n\nSeptember O\nsilver O\nclosed O\nup O\n$ O\n0.004 O\nin O\nNew B-LOC\nYork I-LOC\non O\nThursday O\nat O\n$ O\n5.255 O\nan O\nounce O\n. O\n\n-DOCSTART- O\n\nTripoli B-LOC\ndecks O\nout O\nfor O\ncoup O\ncelebrations O\n. O\n\nMona B-PER\nEltahawy I-PER\n\nTRIPOLI B-LOC\n1996-08-30 O\n\nLibyans B-MISC\nare O\ndressing O\nup O\ntheir O\ncapital O\nTripoli B-LOC\nfor O\ncelebrations O\non O\nSunday O\nof O\nthe O\n27th O\nanniversary O\nof O\nthe O\ncoup O\nwhich O\nbrought O\nMuammar B-PER\nGaddafi I-PER\nto O\npower O\n. O\n\nGreen O\nflags O\nand O\nbanners O\npraise O\nthe O\n\" O\ngreat O\nrevolution O\n\" O\nand O\npromise O\ndefiance O\nagainst O\nUnited B-ORG\nNations I-ORG\nsanctions O\nimposed O\nfor O\nLibya B-LOC\n's O\nrefusal O\nto O\nhand O\nover O\nfor O\ntrial O\ntwo O\nsuspects O\nwanted O\nin O\nconnection O\nwith O\nthe O\n1988 O\nbombing O\nof O\na O\nPan B-ORG\nAm I-ORG\nflight O\nover O\nLockerbie B-LOC\n, O\nScotland B-LOC\n. O\n\n\" O\nWe O\nhave O\nchosen O\nthe O\nchallenge O\nbecause O\nit O\nis O\nour O\nonly O\noption O\n, O\n\" O\nproclaimed O\none O\nbanner O\non O\nthe O\nroad O\nto O\nTripoli B-LOC\nairport O\nwhich O\nserves O\nonly O\ninternal O\nflights O\nbecause O\nof O\nthe O\nsanctions O\n. O\n\nHuge O\nstadium O\nlights O\nare O\ndirected O\nat O\nthe O\ncity O\n's O\nGreen B-LOC\nSquare I-LOC\nwhere O\nmakeshift O\nstages O\nawait O\nSunday O\n's O\nfestivities O\n. O\n\nThree O\nAfrican B-MISC\nleaders O\n-- O\nfrom O\nNiger B-LOC\n, O\nGuinea B-LOC\nand O\nGhana B-LOC\n-- O\nare O\nexpected O\nto O\nattend O\nthe O\ncelebrations O\nmarking O\nSeptember O\n1 O\n, O\n1969 O\nwhen O\na O\ngroup O\nof O\nyoung O\narmy O\nofficers O\n, O\nled O\nby O\na O\n27-year-old O\nGaddafi B-PER\n, O\ndeposed O\nKing O\nMohammed B-PER\nIdris I-PER\n. O\n\n\" O\nThe O\nrevolution O\nhas O\nbrought O\nus O\ngreat O\nachievements O\n... O\n\nWe O\nare O\ncomfortable O\nthe O\nrevolution O\nhas O\ntaken O\ncare O\nof O\nus O\n, O\nimproved O\nour O\nlives O\nand O\ngiven O\nus O\ncapabilites O\n, O\n\" O\nSamer B-PER\nAmmar I-PER\nSoliman I-PER\n, O\n42 O\n, O\ntold O\nReuters B-ORG\nas O\nhe O\ncame O\nout O\nof O\nFriday O\nprayers O\n. O\n\nBut O\nsome O\nLibyans B-MISC\nhave O\nbegun O\nto O\nshow O\ntheir O\ndiscontent O\nin O\nthe O\ncountry O\n's O\neast O\n, O\nwhich O\nhas O\nbecome O\na O\nhotbed O\nof O\nmilitant O\nviolence O\n. O\n\nTripoli-based B-MISC\ndiplomats O\nand O\nexiled O\nopponents O\nsaid O\nGaddafi B-PER\n's O\nairforce O\nblasted O\nin O\nJuly O\nrebel O\nstrongholds O\nin O\nthe O\nmountainous O\nJebel B-LOC\nal-Akhdar I-LOC\nregion O\n. O\n\nTravellers O\narriving O\nin O\nEgypt B-LOC\nsay O\nmilitants O\nand O\npolice O\nofficers O\nclash O\nregularly O\nin O\nBenghazi B-LOC\n. O\n\nAt O\nleast O\n20 O\npeople O\nwere O\nkilled O\nin O\nthe O\ncapital O\nin O\nearly O\nJuly O\nafter O\nbodyguards O\nloyal O\nto O\nGaddafi B-PER\n's O\nsons O\nfired O\nat O\nspectators O\nof O\na O\nfootball O\nmatch O\nwho O\nwere O\nchanting O\nsubversive O\nslogans O\n. O\n\nGaddafi B-PER\nhas O\ndismissed O\nany O\nunrest O\nas O\nthe O\nwork O\nof O\nforeigners O\n, O\nand O\nlast O\nyear O\ndeported O\nthousands O\nof O\nSudanese B-MISC\nand O\nEgyptian B-MISC\nworkers O\n. O\n\n-DOCSTART- O\n\nTwilight O\nzone O\nfor O\nWall B-LOC\nStreet I-LOC\nas O\npolitical O\nrace O\nheats O\nup O\n. O\n\nPierre B-PER\nBelec I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\nFor O\nWall B-LOC\nStreet I-LOC\n, O\nthis O\nis O\nthe O\nseason O\nto O\nbe O\ncautious O\nas O\nthe O\npresidential O\ncontest O\nputs O\nthe O\nstock O\nmarket O\nin O\nthe O\ntwilight O\nzone O\n. O\n\nPresident O\nClinton B-PER\n, O\nBob B-PER\nDole I-PER\nand O\nRoss B-PER\nPerot I-PER\nare O\nhitting O\nthe O\nroad O\nnow O\nthat O\nthe O\npartying O\nis O\nover O\n, O\nand O\npeople O\nwho O\nhave O\nbillions O\nof O\ndollars O\ninvested O\nin O\nstocks O\nwere O\nbracing O\nfor O\npolitical O\npromises O\nthat O\ncould O\nhave O\nan O\nimpact O\non O\ntheir O\nwealth O\n. O\n\nAnalysts O\nbelieve O\nthat O\nthe O\ncandidates O\nwill O\nadd O\nto O\nthe O\nmarket O\n's O\nlist O\nof O\nuncertainties O\n, O\nwhich O\nalready O\nincludes O\nthe O\nquestion O\nof O\nwhether O\nthe O\nFederal B-ORG\nReserve I-ORG\nwill O\nraise O\ninterest O\nrates O\nto O\ncool O\neconomic O\ngrowth O\n. O\n\nThey O\nsay O\nthe O\npoliticians O\nwill O\nneed O\nto O\npromote O\nlegislation O\nthat O\nhelps O\nthe O\neconomy O\nwithout O\nscaring O\nthe O\nsocks O\noff O\nfinancial O\nmarkets O\n. O\n\n\" O\nThe O\nworst O\nthing O\nthat O\ncould O\nhappen O\nfor O\nfinancial O\nmarkets O\nis O\nthat O\nif O\nClinton B-PER\nand O\nDole B-PER\nstart O\nto O\ntrade O\nshots O\nin O\nthe O\nmiddle O\nof O\nthe O\nring O\nwith O\none-upmanship O\n, O\n\" O\nsaid O\nHugh B-PER\nJohnson I-PER\n, O\nchief O\ninvestment O\nofficer O\nat O\nFirst B-ORG\nAlbany I-ORG\nCorp. I-ORG\n\" O\nThat O\n's O\nwhen O\nWall B-LOC\nStreet I-LOC\nwill O\nneed O\nto O\nworry O\n. O\n\" O\n\nHe O\nsaid O\nthat O\nthe O\nbond O\nmarket O\nwould O\nbe O\nthe O\nfirst O\nto O\nreact O\nif O\nthe O\n\" O\nbidding O\n\" O\nintensifies O\nand O\nstocks O\nwould O\nquickly O\ndrop O\nas O\ninterest O\nrates O\nrise O\n. O\n\n\" O\nI O\ndo O\nn't O\nthink O\nit O\nwould O\nimply O\nthe O\ncollapse O\nof O\nthe O\nstock O\nmarket O\n, O\nunless O\nthe O\nrise O\nin O\nrates O\ntouches O\noff O\na O\ndynamic O\nwithin O\nthe O\nmarket O\n, O\nwhich O\nwould O\ninclude O\nselling O\nby O\nportfolio O\nmanagers O\n, O\nredemptions O\nby O\nindividuals O\nof O\nmutual O\nfunds O\nthat O\nwould O\n, O\nin O\nturn O\n, O\npressure O\nthe O\nportfolio O\nmanagers O\nto O\nsell O\neven O\nmore O\nstock O\n. O\n\" O\n\nThis O\nweek O\n, O\nthe O\nmarket O\nweighed O\nDole B-PER\n's O\nproposal O\nto O\nlower O\nfederal O\nincome O\ntaxes O\nby O\n15 O\npercent O\nacross O\nthe O\nboard O\n, O\na O\npackage O\nthat O\ncarries O\na O\nprice O\ntag O\nof O\n$ O\n548 O\nbillion O\n. O\n\nClinton B-PER\nproposes O\nan O\n$ O\n8.4 O\nbillion O\nre-election O\nagenda O\nthat O\nwould O\nspare O\nmost O\nhome-sellers O\nfrom O\ncapital O\ngains O\ntaxes O\nand O\ngive O\nemployers O\ntax O\nincentives O\nto O\nhire O\npeople O\noff O\nthe O\nwelfare O\nrolls O\n. O\n\nClinton B-PER\nclaims O\nDole B-PER\n's O\nplan O\nwould O\nincrease O\nthe O\ndeficit O\n, O\nwhile O\nthe O\nWhite B-LOC\nHouse I-LOC\nsaid O\nsome O\ncorporate O\ntaxes O\nwould O\nbe O\nraised O\nto O\noffset O\nthe O\ncost O\nof O\nthe O\npresident O\n's O\nplan O\n. O\n\nThe O\nexperts O\nsaid O\nthere O\nare O\nsome O\nunusual O\nrisks O\nfor O\nthe O\nmarket O\nfrom O\nthis O\nyear O\n's O\npolitical O\nseason O\nbecause O\nthe O\nrush O\nto O\npromise O\ntax O\ncuts O\nto O\nwin O\nvotes O\ncould O\nupset O\nWall B-LOC\nStreet I-LOC\n's O\nexpectations O\nthat O\nWashington B-LOC\nwill O\nbalance O\nthe O\nbudget O\n. O\n\n\" O\nThe O\nstock O\nmarket O\nwill O\nhave O\nto O\nedit O\nthe O\npromises O\nand O\nthen O\ndo O\na O\nprobability O\nstudy O\non O\nthose O\nedited O\npromises O\n, O\n\" O\nsaid O\nJohn B-PER\nGeraghty I-PER\nat O\nthe O\nconsulting O\nfirm O\nNorth B-ORG\nAmerican I-ORG\nEquity I-ORG\nServices I-ORG\n. O\n\nDuring O\nthe O\npast O\nfour O\npresidential O\nelections O\n, O\nthe O\ncandidate O\nthat O\nhas O\nfavoured O\ntax O\ncuts O\nhas O\nwon O\n. O\n\nRonald B-PER\nReagan I-PER\n's O\ntax O\ncut O\nwon O\nhim O\na O\nsecond O\nfour-year O\nterm O\nin O\nthe O\nWhite B-LOC\nHouse I-LOC\nin O\n1984 O\n, O\nwhile O\nDemocrat B-MISC\nWalter B-PER\nMondale I-PER\n, O\nwho O\npromised O\nhigher O\ntaxes O\n, O\nlost O\n. O\n\nGeorge B-PER\nBush I-PER\nbecame O\npresident O\nin O\n1988 O\non O\nhis O\nno-new-tax O\ncampaign O\nand O\nClinton B-PER\nwon O\nin O\n1992 O\nwith O\na O\npromise O\nto O\nfatten O\nworkers O\n' O\npaychecks O\n. O\n\nThe O\ntrick O\n, O\nthey O\nsaid O\n, O\nwill O\nbe O\nfor O\nthe O\ncandidates O\nto O\ncontinue O\nto O\nconvince O\nWall B-LOC\nStreet I-LOC\nthat O\nthe O\nTreasury B-ORG\n's O\n30-year O\nbond O\n-- O\nthe O\nmost O\nclosely-watched O\ninterest O\nrate O\n-- O\nwill O\nfall O\nto O\nbetween O\n4 O\npercent O\nand O\n5 O\npercent O\nby O\nthe O\nend O\nof O\nthe O\ndecade O\n. O\n\nJohnson B-PER\nsaid O\nthat O\nlong-term O\ninterest O\nrates O\nhave O\nalready O\nbeen O\nspooked O\nby O\nthe O\nelection O\n. O\n\nThe O\nlong-term O\nbond O\njumped O\nthis O\nweek O\nto O\n7.13 O\npercent O\nafter O\nstarting O\nthe O\nyear O\nat O\n5.95 O\npercent O\n. O\n\nThe O\nsurge O\nof O\nbuying O\nin O\nstocks O\nduring O\nthe O\nlast O\ntwo O\nyears O\nhas O\ncome O\namid O\nan O\nenvironment O\nof O\nlow O\ninterest O\nrates O\n, O\nwhich O\nhas O\nboosted O\ncorporate O\nprofits O\n. O\n\nBut O\nthe O\nmarket O\nstalled O\nthis O\nsummer O\nafter O\nthe O\nDow B-MISC\nJones I-MISC\nindustrial O\naverage O\nset O\na O\nrecord O\nhigh O\nof O\n5,778.00 O\npoints O\non O\nMay O\n22 O\n. O\n\n\" O\nThe O\nmarket O\ndoes O\nn't O\nseem O\nto O\nbe O\nable O\nto O\nmake O\nnew O\nhighs O\nand O\nit O\nhas O\nbeen O\nback O\nand O\nforth O\nin O\na O\nfairly O\nhorizontal O\nmode O\nwhich O\nlooks O\nlike O\na O\nholding O\npattern O\n, O\n\" O\nsaid O\nGeraghty B-PER\n. O\n\nHe O\nsaid O\nthe O\nmarket O\nreflects O\nthe O\npolitical O\nuncertainty O\n, O\nnow O\nthat O\nDole B-PER\nhas O\nsharply O\nnarrowed O\nthe O\ngap O\nwith O\nClinton B-PER\nin O\nthe O\npolls O\n. O\n\nGeraghty B-PER\nsaid O\nthat O\nthe O\none O\nthing O\nthat O\ncould O\ncompletely O\nturn O\nthe O\nelection O\naround O\nare O\nnew O\nfindings O\nin O\nthe O\nWhitewater B-LOC\nscandal O\nthat O\nwould O\ndamage O\nthe O\nClintons B-PER\n. O\n\n\" O\nStocks O\nare O\non O\na O\ndelicate O\nedge O\nbecause O\nif O\nsomething O\nhappens O\nthat O\nlooks O\nlike O\nit O\ncould O\nupset O\nthe O\npresidency O\n, O\nit O\ncould O\nthrow O\nthe O\npolitical O\nand O\n, O\nto O\nsome O\nextent O\nthe O\neconomic O\n, O\nprocess O\ninto O\nchaos O\n, O\n\" O\nGeraghty B-PER\nsaid O\n. O\n\nRight O\nnow O\n, O\nWall B-LOC\nStreet I-LOC\nis O\npondering O\nthe O\ncandidates O\n. O\n\n\" O\nWe O\nhave O\nan O\nelection O\nwhere O\nthere O\nare O\nso O\nmany O\nunknown O\nvariables O\nthat O\nmost O\npeople O\nwill O\nprobably O\nwant O\nto O\nhold O\nfire O\n, O\nand O\neven O\ntake O\nthe O\nchance O\nthat O\nthey O\nwill O\nhave O\nto O\npay O\nhigher O\nprices O\nfor O\nstocks O\nafter O\nthe O\nNovember O\nelection O\n, O\nthan O\ntake O\nthe O\nrisk O\nthat O\na O\nshock O\nto O\nthe O\nsystem O\nwill O\nhurt O\nthe O\nstock O\nmarket O\n, O\n\" O\nGeraghty B-PER\nsaid O\n. O\n\nOn O\nFriday O\n, O\nthe O\nDow B-MISC\nJones I-MISC\nindex O\nclosed O\ndown O\n31.44 O\npoints O\nat O\n5,616.21 O\n. O\n\nFor O\nthe O\nweek O\n, O\nit O\nwas O\ndown O\n106.53 O\npoints O\n. O\n\nThe O\nNasdaq B-MISC\ncomposite O\nindex O\nclosed O\n3.53 O\npoints O\nlower O\nFriday O\nat O\n1,141.50 O\n. O\n\nFor O\nthe O\nweek O\n, O\nit O\nwas O\ndown O\n1.55 O\npoints O\n. O\n\nThe O\nStandard B-ORG\n& I-ORG\nPoor I-ORG\n's O\nindex O\nof O\n500 O\nstocks O\nwas O\noff O\n5.41 O\npoints O\nat O\n651.99 O\n, O\ndown O\n15.03 O\npoints O\nfor O\nthe O\nweek O\n. O\n\nThe O\nAmerican B-ORG\nStock I-ORG\nExchange I-ORG\nindex O\nwas O\ndown O\n1.66 O\npoints O\nat O\n559.68 O\n, O\nand O\nwas O\noff O\n1.26 O\nfor O\nthe O\nweek O\n. O\n\n-DOCSTART- O\n\nBrisk O\neconomic O\nreports O\nrattle O\nmarkets O\nanew O\n. O\n\nGlenn B-PER\nSomerville I-PER\n\nWASHINGTON B-LOC\n1996-08-30 O\n\nFactory O\norders O\nrose O\nin O\nJuly O\nand O\nmanufacturing O\nsurged O\nin O\nthe O\nMidwest B-LOC\nin O\nAugust O\n, O\nreports O\nsaid O\nFriday O\n, O\nsparking O\nworries O\nabout O\ninflation O\nthat O\nbattered O\nfinancial O\nmarkets O\nfor O\na O\nsecond O\nstraight O\nday O\n. O\n\nThe O\nCommerce B-ORG\nDepartment I-ORG\nsaid O\norders O\nfor O\nmanufactured O\ngoods O\nclimbed O\n1.8 O\npercent O\nin O\nJuly O\nto O\na O\nseasonally O\nadjusted O\n$ O\n317.6 O\nbillion O\n-- O\nnearly O\ntwice O\nthe O\nincrease O\nthat O\nhad O\nbeen O\nexpected O\n. O\n\nShipments O\nof O\neverything O\nfrom O\nnew O\ncars O\nto O\nfood O\nitems O\nrose O\n, O\nas O\ndid O\norder O\nbacklogs O\n, O\nin O\na O\nsign O\nthat O\nthe O\nstrength O\nin O\nthe O\nindustrial O\nsector O\nwould O\ncontinue O\nin O\ncoming O\nmonths O\n. O\n\nA O\nseparate O\nreport O\nfrom O\nChicago B-LOC\narea O\npurchasing O\nmanagers O\nunderlined O\nthe O\nstrength O\nin O\nmanufacturing O\nas O\nthe O\ngroup O\n's O\nbarometer O\nof O\nmanufacturing O\nin O\nthe O\nregion O\njumped O\nto O\n60 O\nin O\nAugust O\nfrom O\n51.2 O\nin O\nJuly O\n. O\n\nA O\nreading O\nabove O\n50 O\nindicates O\ngrowth O\nin O\nmanufacturing O\n. O\n\nWhile O\nproduction O\nand O\norders O\nrose O\nat O\nMidwest B-LOC\narea O\nbusinesses O\n, O\nthe O\nprices O\nthey O\npaid O\nfor O\ngoods O\nused O\nin O\nmanufacturing O\nremained O\nwell O\nin O\ncheck O\n. O\n\nAnalysts O\nsaid O\nthe O\nreports O\nimplied O\nthe O\neconomy O\nwas O\nnot O\nslowing O\ndown O\nin O\nthe O\nthird O\nquarter O\nafter O\na O\nburst O\nof O\ngrowth O\nin O\nthe O\nspring O\n, O\nand O\nthat O\nthe O\nlull O\nin O\nlate O\nJune O\nand O\nJuly O\nwas O\nmore O\ntemporary O\nthan O\nFederal B-ORG\nReserve I-ORG\npolicy-makers O\nhad O\nwanted O\n. O\n\n\" O\nIt O\nappears O\nthat O\nAugust O\nis O\nshowing O\nan O\neconomy O\nagain O\nreversing O\ncourse O\nand O\nis O\nnot O\nmoving O\nonto O\na O\nsignificantly O\nslower O\ntrack O\nat O\nthis O\npoint O\n, O\n\" O\nsaid O\neconomist O\nLynn B-PER\nReaser I-PER\nof O\nBarnett B-ORG\nBanks I-ORG\nInc. I-ORG\nin O\nJacksonville B-LOC\n, O\nFla B-LOC\n. O\n\nThe O\nreports O\nfanned O\nworries O\non O\nWall B-LOC\nStreet I-LOC\nthat O\nthe O\nFed B-ORG\n, O\nthe O\nnation O\n's O\ncentral O\nbank O\n, O\nwould O\nraise O\nrates O\nnext O\nmonth O\nin O\na O\nbid O\nto O\nward O\noff O\ninflation O\n, O\ndriving O\nstock O\nand O\nbond O\nprices O\nsharply O\nlower O\nfor O\na O\nsecond O\nday O\nrunning O\n. O\n\nThe O\n30-year O\nTreasury B-ORG\nfell O\nalmost O\na O\npoint O\n, O\nraising O\nits O\nyield O\n, O\nwhich O\nmoves O\nin O\nthe O\nopposite O\ndirection O\nfrom O\nthe O\nprice O\n, O\nto O\n7.12 O\npercent O\nfrom O\n7.04 O\npercent O\nlate O\nThursday O\n. O\n\nThe O\nDow B-MISC\nJones I-MISC\nindustrial O\naverage O\nfell O\n31.44 O\npoints O\nto O\n5,616.21 O\nafter O\na O\n64.73-point O\ndecline O\nThursday O\n. O\n\nA O\nthird O\nreport O\nfrom O\nthe O\nCommerce B-ORG\nDepartment I-ORG\n, O\non O\nJuly O\npersonal O\nincome O\nand O\nspending O\n, O\npointed O\nto O\na O\npotential O\nslowdown O\nin O\nconsumer O\nspending O\nthat O\nsome O\nanalysts O\nsaid O\nmay O\nhelp O\nmoderate O\ngrowth O\nin O\nthe O\nsecond O\nhalf O\n. O\n\nIt O\nshowed O\nspending O\nrose O\nonly O\n0.2 O\npercent O\nlast O\nmonth O\nto O\na O\nseasonally O\nadjusted O\nannual O\nrate O\nof O\n$ O\n5.15 O\ntrillion O\nafter O\ndropping O\na O\nrevised O\n0.4 O\npercent O\nin O\nJune O\n. O\n\nIncomes O\nfrom O\nwages O\n, O\nsalaries O\nand O\nall O\nother O\nsources O\ngained O\n0.1 O\npercent O\nto O\na O\nrate O\nof O\n$ O\n6.47 O\ntrillion O\nafter O\na O\n0.9 O\npercent O\njump O\nin O\nJune O\n. O\n\nJuly O\n's O\nslight O\ngain O\nin O\nincomes O\nwas O\nthe O\nweakest O\nin O\nsix O\nmonths O\n, O\nsince O\nJanuary O\nwhen O\nthey O\nwere O\nflat O\n. O\n\nEconomist O\nJoel B-PER\nNaroff I-PER\nof O\nFirst B-ORG\nUnion I-ORG\nbank O\nin O\nPhiladelphia B-LOC\nsaid O\nconsumer O\nspending O\n, O\nwhich O\nfuels O\ntwo-thirds O\nof O\nthe O\nnation O\n's O\neconomy O\n, O\nmay O\nbe O\nmuch O\nslower O\nin O\nthe O\nthird O\nquarter O\nthan O\nin O\nthe O\nfirst O\nhalf O\n, O\nwhich O\nshould O\nslow O\neconomic O\ngrowth O\n. O\n\n\" O\nThe O\nFOMC B-ORG\n( O\nFederal B-ORG\nOpen I-ORG\nMarket I-ORG\nCommittee I-ORG\n) O\nhas O\nbeen O\nforecasting O\na O\nslowing O\nin O\neconomic O\nactivity O\nand O\nmoderating O\nhousehold O\ndemand O\nwill O\nhave O\na O\nlarge O\nimpact O\non O\noverall O\neconomic O\ngrowth O\n, O\n\" O\nNaroff B-PER\nsaid O\nin O\na O\nwritten O\ncomment O\n. O\n\nThe O\npolicy-making O\nFOMC B-ORG\nis O\nto O\nmeet O\non O\nSept O\n. O\n\n24 O\nto O\nplot O\ninterest-rate O\nstrategy O\n. O\n\nIt O\nalready O\nhas O\nadopted O\na O\nbias O\ntoward O\nraising O\nrates O\nto O\nkeep O\na O\nlid O\non O\nwage O\nand O\nprice O\nrises O\nand O\nhelp O\nsustain O\nthe O\n5-1 O\n/ O\n2-year-old O\neconomic O\nexpansion O\n. O\n\nIn O\nan O\ninterview O\non O\nthe O\ncable O\ntelevision O\nnetwork O\nCNBC B-ORG\nFriday O\n, O\nFederal B-ORG\nReserve I-ORG\nGovernor O\nLawrence B-PER\nLindsey I-PER\nsaid O\nthere O\nstill O\nwere O\n\" O\nmixed O\nsignals O\n\" O\nabout O\nthe O\neconomy O\n's O\ndirection O\n. O\n\n\" O\nI O\nthink O\nthat O\n, O\non O\nbalance O\n, O\nit O\nis O\nlooking O\na O\nlittle O\nbit O\non O\nthe O\nstrong O\nside O\n, O\n\" O\nLindsey B-PER\nsaid O\n. O\n\nHe O\nadded O\nthat O\nwith O\nexpansion O\nas O\nsolid O\nas O\nit O\nis O\nand O\nwith O\nunemployment O\nso O\nlow O\n\" O\nthe O\ngreater O\nrisks O\nare O\nclearly O\nthat O\nwe O\nmight O\nsee O\nsome O\noverheating O\n. O\n\" O\n\nWhile O\nJuly O\nconsumer O\nspending O\nrose O\nonly O\nslightly O\n, O\nthere O\nwere O\nample O\nindications O\nthat O\nconsumers O\nremained O\nconfident O\n. O\n\nThe O\nUniversity B-ORG\nof I-ORG\nMichigan I-ORG\n's O\nAugust O\nindex O\nof O\nconsumer O\nsentiment O\n, O\nmade O\navailable O\non O\nFriday O\nto O\npaying O\nsubscribers O\n, O\nrose O\nto O\n95.3 O\nfrom O\n94.7 O\nin O\nJuly O\n. O\n\nReaser B-PER\nsaid O\nstrong O\nconsumer O\nconfidence O\ncoupled O\nwith O\nrelatively O\nlean O\ninventories O\nwere O\nproviding O\nmanufacturers O\nwith O\na O\nreason O\nto O\ngear O\nup O\nproduction O\n. O\n\n\" O\nThe O\neconomy O\nis O\nnot O\ngoing O\nto O\nbe O\nexpanding O\nat O\nthe O\n4.8 O\npercent O\n( O\nannual O\n) O\nrate O\nthat O\nwe O\nhad O\nin O\nthe O\nsecond O\nquarter O\nbut O\nit O\nis O\nlikely O\nto O\nkeep O\nexpanding O\nin O\nthe O\n3 O\npercent O\nrange O\n, O\n\" O\nshe O\nsaid O\n, O\nabove O\nthe O\n2 O\npercent O\nto O\n2-1/4 O\npercent O\nthat O\nthe O\nFed B-ORG\nconsiders O\nto O\nbe O\nnon-inflationary O\n. O\n\nNew O\norders O\nto O\nfactories O\nwere O\nstrong O\nfor O\ndurable O\ngoods O\nlike O\nnew O\ncars O\nand O\nfor O\nnondurables O\nlike O\npaper O\nand O\nfood O\nproducts O\n. O\n\nOrders O\nfor O\ndurable O\ngoods O\n, O\nmeant O\nto O\nlast O\nthree O\nyears O\nor O\nmore O\n, O\nrose O\na O\nrevised O\n1.7 O\npercent O\nin O\nJuly O\nafter O\nfalling O\n0.2 O\npercent O\nin O\nJune O\n. O\n\nOrders O\nfor O\nnondurables O\njumped O\n1.8 O\npercent O\nfollowing O\na O\n1.2 O\npercent O\ndecrease O\nin O\nJune O\n. O\n\n-DOCSTART- O\n\nMexican B-MISC\navocados O\nnot O\nexpected O\nin O\nU.S B-LOC\n. O\n\nMaggie B-PER\nMcNeil I-PER\n\nWASHINGTON B-LOC\n1996-08-30 O\n\nU.S. B-ORG\nAgriculture I-ORG\nDepartment I-ORG\nofficials O\nsaid O\nFriday O\nthat O\nMexican B-MISC\navocados O\n-- O\nwhich O\nare O\nrestricted O\nfrom O\nentering O\nthe O\ncontinental O\nUnited B-LOC\nStates I-LOC\n-- O\nwill O\nnot O\nlikely O\nbe O\nentering O\nU.S. B-LOC\nmarkets O\nany O\ntime O\nsoon O\n, O\neven O\nif O\nthe O\ncontroversial O\nban O\nwere O\nlifted O\ntoday O\n. O\n\n\" O\nThe O\nopportunity O\nto O\nimport O\n( O\nMexican B-MISC\navocados O\n) O\nprobably O\nwo O\nn't O\nbecome O\npossible O\nfor O\nanother O\nyear O\n, O\n\" O\nsaid O\nPaul B-PER\nDrazek I-PER\n, O\nsenior O\ntrade O\nadvisor O\nto O\nAgriculture O\nSecretary O\nDan B-PER\nGlickman I-PER\n. O\n\n\" O\nWe O\ncould O\nlift O\nthe O\nban O\ntomorrow O\n, O\nbut O\nthat O\nwould O\nnot O\nmean O\nanything O\nimmediately O\n, O\n\" O\nsaid O\nDrazek B-PER\n. O\n\" O\n\nWe O\nprobably O\nwould O\nnot O\nsee O\navacados O\ncome O\nin O\nuntil O\nnext O\nseason O\n, O\nnext O\nNovember O\n. O\n\" O\n\nThe O\nAgriculture B-ORG\nDepartment I-ORG\nproposed O\nmore O\nthan O\na O\nyear O\nago O\nto O\nsignificantly O\nease O\nan O\n82-year O\nban O\non O\nMexican B-MISC\navocados O\n. O\n\nUnder O\nthe O\nadministration O\n's O\nproposal O\n, O\nthe O\nborders O\nto O\nthe O\nMexican B-MISC\nproduce O\nwould O\nbe O\nopened O\ninto O\n19 O\nNorthern O\nand O\nNortheastern O\nstates O\nfrom O\nNovember O\nthrough O\nFebruary O\n. O\n\nThe O\nplan O\nhas O\nraised O\na O\nstorm O\nof O\nprotest O\nfrom O\nU.S. B-LOC\navocado O\ngrowers O\n, O\nwho O\nare O\nlargely O\nconcentrated O\nin O\nCalifornia B-LOC\n. O\n\nCalifornia B-LOC\ngrowers O\nhave O\ncharged O\nthat O\nremoving O\nthe O\nrestrictions O\n, O\neven O\non O\na O\nlimited O\nbasis O\n, O\nwould O\nendanger O\nthe O\n$ O\n1 O\nbillion O\nU.S. B-LOC\nindustry O\nif O\npotentially O\nharmful O\nMexican B-MISC\ninsects O\nwere O\nbrought O\ninto O\nthe O\ncountry O\nalong O\nwith O\nthe O\navocados O\n. O\n\nMexican B-MISC\nofficials O\ncontend O\nthat O\nthere O\nis O\nno O\nscientific O\nbasis O\nfor O\nthe O\nban O\n, O\nand O\nthat O\nit O\nis O\nillegal O\nunder O\ninternational O\ntrading O\nrules O\nof O\nthe O\nWorld B-ORG\nTrade I-ORG\nOrganisation I-ORG\n. O\n\nProponents O\nof O\nthe O\nplan O\ndiscount O\nthe O\nworries O\nof O\nthe O\nU.S. B-LOC\ngrowers O\nand O\nsay O\nthe O\nplan O\nhas O\nenough O\nsafeguards O\nbuilt O\ninto O\nit O\nto O\neliminate O\nany O\nsignificant O\nthreat O\nto O\nAmerican B-MISC\nproducers O\n. O\n\nUnder O\nthe O\nproposal O\n, O\nonly O\nimports O\nof O\nexport-quality O\navocados O\ngrowing O\nin O\napproved O\norchards O\nin O\nMichoacan B-LOC\n, O\nMexico B-LOC\n, O\nthe O\ncountry O\n's O\nmain O\navocado O\narea O\n, O\nwould O\nbe O\nallowed O\n. O\n\nMexican B-MISC\ngrowers O\nand O\ndistributors O\nwould O\nhave O\nto O\nabide O\nby O\nstrict O\nrules O\nestablished O\nby O\nthe O\nMexican B-MISC\nand O\nU.S. B-LOC\nagriculture O\nagencies O\n. O\n\nThe O\nCalifornia B-ORG\nAvocado I-ORG\nCommission I-ORG\n-- O\nwhich O\nhas O\nspearheaded O\nthe O\nopposition O\nto O\nlifting O\nthe O\nban O\n-- O\nsaid O\nnew O\ndata O\nthe O\ngroup O\nsubmitted O\nto O\nthe O\nAgriculture B-ORG\nDepartment I-ORG\nlast O\nspring O\nshows O\nthe O\ndepartment O\nunderestimated O\nthe O\npest O\nproblem O\nin O\nMexico B-LOC\nand O\nhave O\nurged O\nthat O\nthe O\nagency O\nreopen O\nits O\nstudy O\nof O\nthe O\nissue O\n. O\n\nThe O\nadministration O\nis O\nstill O\nstudying O\nthe O\nnew O\ndata O\n, O\nand O\nofficials O\nhave O\nsaid O\nthat O\nif O\nexperts O\nthink O\nthe O\ninformation O\nis O\nsignificant O\n, O\nthe O\nagency O\ncould O\nreopen O\nits O\ninvestigation O\n. O\n\nBut O\nU.S. B-LOC\navocado O\nindustry O\nsources O\nsaid O\nthat O\nwhile O\nthey O\nmay O\nhave O\ndelayed O\nthe O\nplan O\nfor O\na O\nwhile O\n, O\nthey O\nultimately O\ndo O\nnot O\nexpect O\nthe O\nadministration O\nto O\nchange O\nits O\nposition O\n. O\n\n\" O\nFrom O\na O\ncommon-sense O\nview O\n, O\nthe O\ndepartment O\nshould O\nreconsider O\nthis O\nplan O\n, O\nbut O\ndue O\nto O\npolitics O\nthey O\nwill O\nprobably O\ngo O\nahead O\nwith O\nthis O\n, O\n\" O\nsaid O\nTom B-PER\nBellamore I-PER\nof O\nthe O\nCalifornia B-LOC\navocado O\ngroup O\n. O\n\nAdministration O\nofficials O\nsaid O\nthey O\nwant O\nto O\nget O\nthe O\nissue O\nresolved O\nas O\nquickly O\nas O\npossible O\n, O\nbut O\nsaid O\nthere O\nis O\nno O\ntimetable O\nthey O\nare O\nworking O\nunder O\n. O\n\n\" O\nIt O\n's O\na O\nvery O\ncomplicated O\nissue O\n, O\n\" O\nsaid O\nthe O\nAgriculture B-ORG\nDepartment I-ORG\n's O\nDrazek B-PER\n. O\n\" O\n\nWe O\n'll O\nget O\nit O\nresolved O\nas O\nquickly O\nas O\nwe O\ncan O\n, O\nbased O\non O\nthe O\nbest O\navailable O\nscience O\n. O\n\" O\n\n-DOCSTART- O\n\nU.S. B-LOC\nCardinal O\nBernardin B-PER\nsays O\nhas O\nterminal O\ncancer O\n. O\n\nCHICAGO B-LOC\n1996-08-30 O\n\nChicago B-LOC\nCardinal O\nJoseph B-PER\nBernardin I-PER\n, O\nhead O\nof O\nthe O\nsecond-largest O\nU.S. B-LOC\nRoman B-MISC\nCatholic I-MISC\narchdiocese O\n, O\nsaid O\non O\nFriday O\nhis O\ndoctors O\nhad O\ndiagnosed O\nhim O\nas O\nhaving O\nliver O\ncancer O\nand O\nhe O\nhad O\na O\nyear O\nor O\nless O\nto O\nlive O\n. O\n\nBernardin B-PER\n, O\n68 O\n, O\nunderwent O\nextensive O\nsurgery O\nfor O\npancreatic O\ncancer O\nin O\nJune O\n1995 O\nfollowed O\nby O\nmonths O\nof O\nchemotherapy O\n, O\nwhich O\nhe O\nsaid O\nmade O\nhim O\nmore O\naware O\nof O\nhis O\nown O\nvulnerabilities O\nand O\nthe O\nneed O\nto O\nminister O\nto O\nthe O\nsick O\n. O\n\n\" O\nOn O\nWednesday O\n, O\nexaminations O\nindicated O\nthat O\nthe O\ncancer O\nhas O\nreturned O\n, O\nthis O\ntime O\nin O\nthe O\nliver O\n. O\n\nI O\nam O\ntold O\nthat O\nit O\nis O\nterminal O\nand O\nthat O\nmy O\nlife O\nexpectancy O\nis O\none O\nyear O\nor O\nless O\n, O\n\" O\na O\ncomposed O\nBernardin B-PER\ntold O\na O\nnews O\nconference O\n. O\n\nIn O\n14 O\nyears O\nas O\nChicago B-LOC\n's O\narchbishop O\n, O\nhe O\nbuilt O\na O\nprayerful O\n, O\nsaintly O\nimage O\nand O\nwas O\ndeeply O\ninvolved O\nin O\nworld O\nchurch O\nissues O\nand O\npublicly O\ncommitted O\nto O\nrooting O\nout O\nabuses O\nby O\nclergy O\n. O\n\n\" O\nI O\nhave O\nbeen O\nassured O\nthat O\nI O\nstill O\nhave O\nsome O\nquality O\ntime O\nleft O\n, O\n\" O\nhe O\nsaid O\n, O\nsaying O\nhe O\nwould O\nundergo O\na O\nnew O\nform O\nof O\nchemotherapy O\nbut O\nhis O\ndoctors O\nhave O\ntold O\nhim O\nthere O\nwas O\nonly O\na O\nslim O\nchance O\nof O\na O\ncure O\nand O\nthe O\nliver O\ncancer O\nwas O\ninoperable O\n. O\n\n\" O\nIt O\n's O\nnot O\ngoing O\nto O\nbe O\neasy O\nto O\nsay O\ngoodbye O\nto O\neverybody O\n. O\n\nDeath O\ndoes O\nhave O\nsome O\nsad O\ndimensions O\nto O\nit O\nbut O\nI O\nam O\na O\nman O\nof O\nfaith O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nDeath O\nis O\na O\nnatural O\nphenomenom O\n. O\n\" O\n\nHe O\nsaid O\nhe O\nwould O\n\" O\nserve O\nuntil O\nthe O\nend O\n\" O\nas O\ncardinal O\n. O\n\nPancreatic O\ncancer O\nis O\namong O\nthe O\nmost O\ndeadly O\nforms O\nof O\nthe O\ndisease O\n, O\nalthough O\nBernardin B-PER\n's O\ncase O\nwas O\ncaught O\nearly O\n. O\n\nSurgeons O\nremoved O\na O\ncancerous O\nkidney O\n, O\nparts O\nof O\nhis O\npancreas O\nand O\nstomach O\n, O\nsmall O\nintestine O\n, O\nbile O\nduct O\nand O\nsurrounding O\ntissues O\n. O\n\nHe O\nmade O\na O\nrapid O\nrecovery O\nand O\nresumed O\nmost O\nof O\nhis O\nduties O\n, O\nbut O\nthen O\ndeveloped O\na O\ndeteriorating O\ncondition O\nin O\nhis O\nspine O\nthat O\ncaused O\nhim O\ngreat O\npain O\nand O\nshortened O\nhis O\nheight O\nby O\nseveral O\ninches O\n. O\n\nHe O\nwas O\nscheduled O\nto O\nundergo O\nback O\nsurgery O\nnext O\nmonth O\n, O\nbut O\nthat O\nwas O\ncancelled O\nwhen O\nthe O\ncancer O\nwas O\ndiscovered O\nin O\nhis O\nliver O\nin O\norder O\nto O\navoid O\ndelaying O\nthe O\nstart O\nof O\nchemotherapy O\n. O\n\nThe O\nspare O\n, O\nsoft-spoken O\nson O\nof O\nan O\nItalian B-MISC\nstonecutter O\ntook O\nover O\nthe O\nChicago B-LOC\narchdiocese O\n, O\nthe O\nnation O\n's O\nsecond-largest O\nafter O\nLos B-LOC\nAngeles I-LOC\n, O\nwith O\n2.3 O\nmillion O\nparishioners O\n, O\nin O\n1982 O\n. O\n\nIronically O\n, O\nBernardin B-PER\n, O\nwho O\ndeveloped O\na O\nprogressive O\n, O\nmuch-praised O\nprogramme O\nto O\ndeal O\nwith O\npedophilia O\ninvolving O\npriests O\n, O\nbecame O\nthe O\nhighest-ranking O\nchurch O\nofficial O\never O\naccused O\nof O\nsexual O\nimproprieties O\nwhen O\na O\nformer O\nseminary O\nstudent O\nleveled O\ncharges O\nin O\n1993 O\nthat O\nhe O\nhad O\nbeen O\nsexually O\nabused O\nby O\nBernardin B-PER\nduring O\nthe O\n1970s O\n. O\n\nBernardin B-PER\nsteadfastly O\ndenied O\nthe O\ncharges O\nand O\nthe O\nformer O\nstudent O\nlater O\nrecanted O\nhis O\ntale O\nof O\nabuse O\n. O\n\nBernardin B-PER\nprayed O\nwith O\nhim O\nbefore O\nhe O\ndied O\nfrom O\nAIDS B-MISC\nlast O\nyear O\n. O\n\nBernardin B-PER\n, O\nwho O\nbecame O\narchbishop O\nof O\nCincinnati B-LOC\nin O\n1972 O\n, O\nplayed O\nan O\nincreasingly O\nprominent O\nrole O\nin O\nthe O\nU.S. B-LOC\nchurch O\nas O\na O\nmoderate O\nvoice O\nof O\ncompromise O\namong O\nliberals O\nand O\nconservatives O\nin O\nthe O\nranks O\nof O\nthe O\nbishops O\n. O\n\nThis O\nmonth O\n, O\nhe O\nannounced O\nthat O\nhe O\nwould O\noversee O\na O\nseries O\nof O\nconferences O\nto O\nfind O\n\" O\ncommon O\nground O\n\" O\namong O\nAmerican B-MISC\nCatholics I-MISC\n. O\n\nPreviously O\n, O\nhe O\nwas O\ninstrumental O\nin O\ndrafting O\nchurch O\npolicy O\non O\nwar O\n, O\npeace O\nand O\nnuclear O\narms O\n, O\nand O\nfor O\nseven O\nyears O\nhe O\nheaded O\nthe O\nbishops O\n' O\nanti-abortion O\npolicy O\ncommittee O\n, O\nespousing O\na O\npolicy O\ndescribing O\nhuman O\nlife O\nas O\na O\n\" O\nseamless O\ngarment O\n. O\n\" O\n\n-DOCSTART- O\n\nBoatmen B-ORG\n's I-ORG\ndeal O\ncould O\nspark O\nmore O\nmergers O\n. O\n\nBrad B-PER\nDorfman I-PER\n\nCHICAGO B-LOC\n1996-08-30 O\n\nThe O\n$ O\n9.5 O\nbillion O\nproposed O\nacquisition O\nof O\nBoatmen B-ORG\n's I-ORG\nBancshares I-ORG\nInc. I-ORG\nby O\nNationsBank B-ORG\nCorp. I-ORG\ncould O\nspark O\na O\nflurry O\nof O\nother O\nmergers O\ninvolving O\nMissouri B-LOC\nbanks O\n, O\nwhich O\nuntil O\nlast O\nyear O\nwere O\nprotected O\nfrom O\noutside O\nbuyers O\nby O\nstate O\nregulations O\n. O\n\n\" O\nNationsBank B-ORG\njust O\nstrolled O\ninto O\nthe O\nMidwest B-LOC\nand O\nbagged O\nthe O\nbiggest O\nbanking O\ntrophy O\nin O\nthe O\nlandscape O\n, O\n\" O\nsaid O\nMichael B-PER\nAncell I-PER\n, O\nbanking O\nindustry O\nanalyst O\nat O\nEdward B-ORG\nD. I-ORG\nJones I-ORG\n& I-ORG\nCo I-ORG\n. O\n\" O\n\nWhoever O\nwants O\na O\nbig O\nmarket O\nposition O\nin O\nthe O\nMidwest B-LOC\nhas O\nto O\ncome O\nin O\nand O\ngrab O\nMercantile B-ORG\nor O\nCommerce B-ORG\n. O\n\" O\n\nSt. B-MISC\nLouis-based I-MISC\nMercantile B-ORG\nBancorp I-ORG\nInc. I-ORG\n, O\na O\nbank O\nholding O\ncompany O\nwith O\n$ O\n18.04 O\nbillion O\nin O\nassets O\n, O\nwas O\nseen O\nby O\nmany O\nanalysts O\nas O\nthe O\nmost O\nattractive O\nMissouri B-LOC\nfranchise O\nin O\nsize O\nafter O\nBoatmen B-ORG\n's I-ORG\n. O\n\nKansas B-LOC\nCity I-LOC\n, O\nMo.-based B-MISC\nCommerce B-ORG\nBancshares I-ORG\nInc. I-ORG\n, O\nwith O\n$ O\n9.32 O\nbillion O\nin O\nassets O\n, O\nalso O\ncould O\nhelp O\na O\nregional O\nbank O\nestablish O\na O\nstrong O\npresence O\nin O\nthe O\nlower O\nMidwest B-LOC\n, O\nanalysts O\nadded O\n. O\n\n\" O\nIt O\nfocuses O\nmore O\nattention O\non O\nMercantile B-ORG\n, O\nCommerce B-ORG\nand O\nRoosevelt B-ORG\n, O\n\" O\nsaid O\nJames B-PER\nWeber I-PER\n, O\nanalyst O\nat O\nA.G. B-ORG\nEdwards I-ORG\n& I-ORG\nSons I-ORG\n. O\n\nRoosevelt B-ORG\nFinancial I-ORG\nGroup I-ORG\nInc I-ORG\nis O\na O\n$ O\n9.33 O\nbillion O\nasset-St B-MISC\n. I-MISC\n\nLouis B-MISC\nbased O\nthrift O\n. O\n\n\" O\nNow O\n... O\nthe O\nmost O\ncoveted O\nbank O\nout O\nthere O\nis O\nMercantile B-ORG\n, O\n\" O\nWeber B-PER\nsaid O\n. O\n\nMercantile B-ORG\nand O\nCommerce B-ORG\ndid O\nnot O\nreturn O\nphone O\ncalls O\nseeking O\ncomment O\n. O\n\nAmong O\nthose O\nseen O\nas O\nhaving O\nan O\ninterest O\nin O\nbuying O\nin O\nMissouri B-LOC\nare O\nMinneapolis-based B-MISC\nFirst B-ORG\nBank I-ORG\nSystem I-ORG\nInc. I-ORG\nand O\nNorwest B-ORG\nCorp. I-ORG\n, O\nOhio-based B-MISC\nKeyCorp B-ORG\nand O\nBanc B-ORG\nOne I-ORG\nCorp. I-ORG\n, O\nand O\nFirst B-ORG\nChicago I-ORG\nNBD I-ORG\nCorp. I-ORG\nin O\nIllinois B-LOC\n. O\n\nRepresentatives O\nof O\nFirst B-ORG\nBank I-ORG\n, O\nNorwest B-ORG\n, O\nBanc B-ORG\nOne I-ORG\nand O\nFirst B-ORG\nChicago I-ORG\nsaid O\nthe O\nbanks O\ndo O\nnot O\ncomment O\non O\nrumors O\nof O\npossible O\nmergers O\nor O\nacquisitions O\n. O\n\nKeyCorp B-ORG\n, O\ncontacted O\nby O\nphone O\n, O\nwould O\nnot O\ncomment O\n. O\n\nWith O\na O\npresence O\nin O\nnine O\nstates O\nand O\n$ O\n41 O\nbillion O\nin O\nassets O\n, O\n\nBoatmen B-ORG\n's I-ORG\nwas O\nthe O\nprize O\nin O\nMissouri B-LOC\n, O\nwhere O\nbarriers O\nto O\noutside O\nacquirers O\nwere O\nbrought O\ndown O\nlast O\nyear O\nby O\na O\nfederal O\nbanking O\nstatute O\n. O\n\n\" O\nBoatmen B-ORG\n's I-ORG\nwas O\nthe O\nplum O\nof O\nMissouri B-LOC\nand O\nwas O\nthe O\nplum O\nof O\nthe O\ncentral O\nMidwest B-LOC\n, O\n\" O\nWeber B-PER\nsaid O\n. O\n\nTalk O\nthat O\nthe O\nMissouri B-LOC\nbanks O\nwere O\nseeking O\ninflated O\nprices O\nfrom O\nbuyers O\nwas O\nseen O\nas O\na O\nreason O\na O\ndeal O\nhas O\nnot O\noccurred O\nsooner O\n. O\n\nBut O\nNationsBank B-ORG\n's O\nbid O\n, O\nrepresenting O\na O\npremium O\nof O\n40 O\npercent O\nfor O\nBoatmen B-ORG\n's I-ORG\nstock O\n, O\nwas O\nlarge O\nenough O\nto O\nget O\nthe O\ndeal O\ndone O\n. O\n\n\" O\nI O\nthink O\nBoatmen B-ORG\n's I-ORG\nwas O\nshopping O\nitself O\n, O\nand O\neverybody O\nknew O\nif O\nyou O\nwanted O\nto O\nbe O\nthe O\nwinning O\nbuyer O\nhere O\n, O\nyou O\nhad O\nto O\nmake O\nthe O\nbid O\nnobody O\nwould O\nbeat O\n, O\n\" O\nAncell B-PER\nsaid O\n. O\n\nBut O\nsome O\nanalysts O\ncautioned O\nthat O\nother O\ntargets O\nshould O\nnot O\nexpect O\nas O\nlarge O\na O\npremium O\n. O\n\nThey O\nalso O\nquestioned O\nwhether O\nNationsBank B-ORG\ncan O\nrecoup O\nshareholder O\nvalue O\nwith O\nsuch O\na O\nlarge O\nbid O\nfor O\nBoatmen B-ORG\n's I-ORG\n. O\n\n\" O\nI O\nthink O\ninitially O\nsome O\nstocks O\nwill O\ntrade O\nup O\non O\nsympathy O\n, O\nbut O\nthe O\nwild O\npremium O\nNationsBank B-ORG\nput O\non O\nthis O\ndeal O\nhere O\n, O\nI O\ndo O\nn't O\nsee O\na O\nlot O\nof O\nother O\ndeals O\nbeing O\ndone O\nat O\nthis O\npremium O\n, O\n\" O\nsaid O\nMichael B-PER\nDurante I-PER\n, O\nanalyst O\nat O\nMcDonald B-ORG\n& I-ORG\nCo I-ORG\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\ntight-lipped O\non O\nLibya B-LOC\n's O\naward O\nto O\nFarrakhan B-PER\n. O\n\nWASHINGTON B-LOC\n1996-08-30 O\n\nThe O\nState B-ORG\nDepartment I-ORG\nrefused O\nto O\nspeculate O\non O\nFriday O\non O\nwhat O\nmight O\nhappen O\nin O\nthe O\ncase O\nof O\nLouis B-PER\nFarrakhan I-PER\n, O\nthe O\nU.S. B-LOC\nblack O\nleader O\nwho O\nwas O\nawarded O\na O\n$ O\n250,000 O\nhuman O\nrights O\nprize O\nby O\nLibya B-LOC\n. O\n\n\" O\nI O\n'm O\nnot O\ngoing O\nto O\nspeculate O\nabout O\nwhat O\nmay O\nor O\nmay O\nnot O\nhappen O\nin O\nthat O\ncase O\n, O\n\" O\nState B-ORG\nDepartment I-ORG\nspokesman O\nGlyn B-PER\nDavies I-PER\nsaid O\n. O\n\" O\n\n... O\nThe O\nview O\nof O\nthe O\nU.S. B-LOC\ngovernment O\non O\n( O\nFarrakhan B-PER\n's O\n) O\nnot O\naccepting O\nany O\ngifts O\nfrom O\nLibya B-LOC\nis O\nwell-known O\n. O\n\" O\n\nDavies B-PER\nalso O\nnoted O\n: O\n\" O\nWe O\n've O\ntalked O\nabout O\nthe O\npassport O\nrestriction O\nfor O\ntravel O\nto O\nLibya B-LOC\n\" O\nbut O\nhe O\ndid O\nnot O\nelaborate O\n. O\n\nThe O\nU.S. B-ORG\nTreasury I-ORG\nDepartment I-ORG\non O\nWednesday O\ndenied O\nFarrakhan B-PER\n's O\napplication O\nto O\nreceive O\nthe O\n$ O\n250,000 O\naward O\nor O\na O\n$ O\n1 O\nbillion O\ndonation O\nLibyan B-MISC\nleader O\nMuammar B-PER\nGaddafi I-PER\nhad O\npledged O\nto O\nFarrakhan B-PER\n's O\nNation B-ORG\nof I-ORG\nIslam I-ORG\ngroup O\nafter O\nthey O\nmet O\nlast O\nJanuary O\n. O\n\nFarrakhan B-PER\norganised O\nlast O\nOctober O\n's O\nMillion B-MISC\nMan I-MISC\nMarch I-MISC\nthat O\nbrought O\nthousands O\nof O\nblack O\nmen O\nto O\nWashington B-LOC\nfor O\na O\npeaceful O\nrally O\n. O\n\nThe O\nTreasury B-ORG\nDepartment I-ORG\nsaid O\nLibya B-LOC\nwas O\non O\nthe O\nU.S. B-LOC\nlist O\nof O\nstates O\nthat O\nsponsor O\ninternational O\nterrorism O\nand O\nnoted O\nthat O\nTripoli B-LOC\nhas O\nrefused O\nto O\nhand O\nover O\ntwo O\nLibyan B-MISC\nsuspects O\nin O\nthe O\n1988 O\nbombing O\nof O\nPan B-MISC\nAm I-MISC\nflight I-MISC\n103 I-MISC\nover O\nLockerbie B-LOC\n, O\nScotland B-LOC\n. O\n\nThat O\nrefusal O\nled O\nto O\nthe O\nimposition O\nof O\nU.N. B-ORG\nsanctions O\non O\nLibya B-LOC\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nGulf I-LOC\nrig O\ndown O\nby O\none O\nto O\n162 O\nin O\nweek O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\nThere O\nwere O\n162 O\nrigs O\nunder O\ncontract O\nin O\nthe O\nU.S. B-LOC\nGulf I-LOC\nas O\nof O\nAugust O\n30 O\n, O\ndown O\none O\nfrom O\nthe O\nprior O\nweek O\n, O\nOffshore B-ORG\nData I-ORG\nServices I-ORG\nsaid O\n. O\n\nThe O\nutilization O\nrate O\nfor O\nrigs O\nworking O\nin O\nthe O\nGulf B-LOC\n, O\nbased O\non O\na O\ntotal O\nfleet O\nof O\n181 O\n, O\nwas O\n89.5 O\npercent O\n. O\n\nThe O\nnumber O\nof O\nworking O\nrigs O\nin O\nEuropean B-MISC\n/ O\nMediterranean B-MISC\nremained O\nunchanged O\nthis O\nweek O\n, O\nwith O\n105 O\nrigs O\nunder O\ncontract O\nout O\nof O\na O\ntotal O\nfleet O\nof O\n105 O\n, O\na O\nutilization O\nrate O\nof O\n100 O\npercent O\n. O\n\nThe O\nworldwide O\nrig O\ncount O\nfell O\nby O\none O\nto O\n554 O\nout O\nof O\na O\ntotal O\nfleet O\nof O\n608 O\n, O\nmaking O\nthe O\nutilization O\nrate O\n91.1 O\npercent O\n. O\n\n-- O\nNew B-ORG\nYork I-ORG\nEnergy I-ORG\nDesk I-ORG\n212-859-1620 O\n\n-DOCSTART- O\n\nDole B-PER\nteam O\nseeking O\nto O\npin O\ndown O\ndebate O\ndetails O\n. O\n\nIRVINE B-LOC\n, O\nCalif B-LOC\n1996-08-30 O\n\nNow O\nthat O\nthe O\nparty O\nconventions O\nare O\nover O\n, O\nRepublicans B-MISC\nhave O\nsignalled O\nthey O\nare O\nready O\nto O\nmove O\ninto O\nthe O\nnext O\nphase O\nof O\nthe O\ncampaign O\nand O\nmeet O\nwith O\nPresident O\nClinton B-PER\n's O\naides O\nto O\nhammer O\nout O\ndetails O\nof O\npresidential O\ndebates O\n. O\n\nThe O\nDole B-PER\ncampaign O\nreleased O\na O\nletter O\nFriday O\ninviting O\ntheir O\nClinton B-PER\ncounterparts O\nto O\nmeet O\nwith O\nDole B-PER\ncampaign O\nmanager O\nScott B-PER\nReed I-PER\nto O\ndiscuss O\nparticulars O\nof O\nthe O\ntelevised O\ndebates O\n. O\n\n\" O\nNext O\nweek O\n, O\na O\nsmall O\ngroup O\nof O\nrepresentatives O\nfrom O\neach O\nof O\nour O\ncampaigns O\nshould O\nmeet O\nto O\naddress O\nparticipants O\n, O\nformat O\n, O\ntiming O\nand O\nlogistical O\nissues O\nsurrounding O\nthe O\ndebates O\n, O\n\" O\nDole B-PER\ncampaign O\nmanager O\nScott B-PER\nReed I-PER\nwrote O\nto O\nClinton B-PER\ncampaign O\nmanager O\nPeter B-PER\nKnight I-PER\n. O\n\nTentative O\ndates O\nfor O\nthe O\ndebates O\nare O\nSept O\n. O\n\n25 O\n, O\nOct. O\n9 O\nand O\nOct. O\n16 O\n. O\n\nThe O\nvice O\npresidential O\ndebate O\nis O\nscheduled O\nfor O\nOct. O\n2 O\n. O\n\nFormer O\nSouth B-LOC\nCarolina I-LOC\nGov O\n. O\n\nCarroll B-PER\nCampbell I-PER\n, O\nwho O\nwas O\non O\nDole B-PER\n's O\nvice O\npresidential O\nshort O\nlist O\nbefore O\nDole B-PER\ndecided O\non O\nJack B-PER\nKemp I-PER\n, O\nwill O\nhead O\nDole B-PER\n's O\nteam O\n. O\n\nA O\ndecision O\nis O\nexpected O\nby O\nmid-September O\non O\nwhether O\nTexas B-LOC\nbillionaire O\nRoss B-PER\nPerot I-PER\n, O\nthe O\nReform B-ORG\nParty I-ORG\ncandidate O\n, O\nwill O\nbe O\nallowed O\nto O\nparticipate O\nin O\nthe O\ndebates O\n, O\nwhich O\nare O\nsponsored O\nby O\nthe O\nCommission B-ORG\non I-ORG\nPresidential I-ORG\nDebates I-ORG\n, O\na O\nnon-profit O\n, O\nnon-partisan O\norganisation O\nthat O\ntook O\nover O\nthe O\nforums O\nin O\n1988 O\nfrom O\nthe O\nLeague B-ORG\nof I-ORG\nWomen I-ORG\nVoters I-ORG\n. O\n\n-DOCSTART- O\n\nTitanic B-MISC\nrecovery O\nmission O\nis O\nscrapped O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\nEquipment O\nproblems O\nand O\nmechanical O\nfailure O\nforced O\na O\nrecovery O\nexpedition O\nto O\ngive O\nup O\nefforts O\nto O\nretrieve O\na O\ngiant O\nslab O\nof O\nthe O\nRMS B-MISC\nTitanic I-MISC\nfrom O\nthe O\nocean O\nfloor O\n, O\na O\nspokeswoman O\nsaid O\non O\nFriday O\n. O\n\nA O\n20-ton O\npiece O\nof O\nthe O\nTitanic B-MISC\n's O\nsteel O\nhull O\n, O\nwhich O\nhad O\nbeen O\nattached O\nby O\ncables O\nto O\na O\nrecovery O\nship O\noff O\nthe O\ncoast O\nof O\nNewfoundland B-LOC\n, O\nCanada B-LOC\n, O\nfell O\nback O\nto O\nthe O\nbottom O\nof O\nthe O\nsea O\n, O\nsaid O\nErin B-PER\nPurcell I-PER\nof O\nBoston-based B-MISC\nReagan B-ORG\nCommunications I-ORG\nthat O\nrepresents O\ntwo O\nof O\nthe O\nships O\nused O\nin O\nthe O\nexpedition O\n. O\n\nThe O\npiece O\nof O\nhull O\n, O\nlifted O\nfrom O\nthe O\nocean O\nfloor O\nby O\nmeans O\nof O\nseveral O\ndiesel-filled O\nbags O\n, O\nhad O\nbeen O\nstuck O\nabout O\n200 O\nfeet O\n( O\nabout O\n70 O\nmetres O\n) O\nbelow O\nthe O\nwater O\n's O\nsurface O\nbefore O\nit O\nfell O\n, O\nshe O\nsaid O\n. O\n\nIt O\nfell O\nas O\nrecovery O\ncrews O\nwere O\ntrying O\nto O\nhaul O\nthe O\npiece O\ninto O\nmore O\nshallow O\nwater O\nand O\nseveral O\nof O\nthe O\nbags O\nburst O\nand O\ncables O\nsnapped O\n, O\nshe O\nsaid O\n. O\n\nThe O\nsteel-hulled O\nTitanic B-MISC\n, O\nthought O\nto O\nbe O\nunsinkable O\n, O\nstruck O\nan O\niceberg O\non O\nApril O\n14 O\n, O\n1912 O\n, O\nand O\nsank O\n, O\nkilling O\n1,523 O\nof O\nthe O\n2,200 O\npassengers O\nand O\ncrew O\non O\nboard O\n. O\n\nThe O\nwreck O\nwas O\nlocated O\nin O\n1985 O\n. O\n\nPassengers O\nwho O\nhad O\npaid O\n$ O\n1,500 O\nand O\nup O\nto O\naccompany O\nthe O\nrecovery O\nexpedition O\non O\ntwo O\ncruise O\nships O\nhad O\nreturned O\nback O\nto O\nport O\non O\nThursday O\n, O\nPurcell B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nBonn B-LOC\nappeals O\nfor O\nMiddle B-LOC\nEast I-LOC\npeace O\n. O\n\nBONN B-LOC\n1996-08-30 O\n\nThe O\nGerman B-MISC\ngovernment O\nurged O\nIsraelis B-MISC\nand O\nPalestinians B-MISC\non O\nFriday O\nto O\navoid O\nany O\ncourse O\nof O\naction O\nthat O\nmight O\njeopardise O\nthe O\npeace O\nprocess O\nin O\nthe O\nMiddle B-LOC\nEast I-LOC\n. O\n\nIsrael B-LOC\nannounced O\nthis O\nweek O\nthe O\nexpansion O\nof O\nJewish B-MISC\nWest B-LOC\nBank I-LOC\nsettlements O\nsurrounding O\nJerusalem B-LOC\nand O\nthe O\ndemolition O\nof O\nan O\nArab B-MISC\ncommunity O\ncentre O\nin O\nEast B-LOC\nJerusalem I-LOC\n. O\n\nCity O\nofficials O\nthere O\nsaid O\nthe O\ncentre O\nwas O\nbeing O\nerected O\nillegally O\n. O\n\nBut O\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\nsaid O\nthe O\nmoves O\nby O\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\n's O\ngovernment O\nwere O\ntantamount O\nto O\nwar O\n. O\n\nTension O\nhas O\nbeen O\nrising O\nin O\nthe O\nregion O\nsince O\n. O\n\n\" O\nWe O\nbelieve O\nthat O\nthe O\nIsraeli B-MISC\nsettlement O\npolicy O\nin O\nthe O\noccupied O\nareas O\nis O\nan O\nobstacle O\nto O\nthe O\nestablishment O\nof O\npeace O\n, O\n\" O\nGerman B-MISC\nForeign B-ORG\nMinistry I-ORG\nspokesman O\nMartin B-PER\nErdmann I-PER\nsaid O\n. O\n\n\" O\nAll O\nconcerned O\nmust O\navoid O\ntaking O\nany O\ncourse O\nof O\naction O\nthat O\ncould O\npose O\nan O\nobstacle O\nto O\nthe O\npeace O\nprocess O\nand O\nwhich O\ncould O\nmake O\na O\npeaceful O\nsolution O\ndifficult O\n, O\n\" O\nhe O\nsaid O\n, O\nas O\nnews O\ncame O\nof O\na O\nrenewed O\nbreakdown O\nin O\nArab-Israeli B-MISC\npeace O\ntalks O\nin O\nJerusalem B-LOC\n. O\n\nErdmann B-PER\ntold O\nreporters O\nBonn B-LOC\nsupported O\nEuropean B-ORG\nUnion I-ORG\nefforts O\nto O\npersuade O\nIsrael B-LOC\nto O\nstop O\nfurther O\nJewish B-MISC\nsettlement O\non O\nthe O\nWest B-LOC\nBank I-LOC\n. O\n\nThe O\nforeign O\nministry O\nlater O\nannounced O\nIsraeli B-MISC\nForeign O\nMinister O\nDavid B-PER\nLevy I-PER\nwould O\nvisit O\nBonn B-LOC\nfor O\ntalks O\nwith O\nhis O\nGerman B-MISC\ncounterpart O\nKlaus B-PER\nKinkel I-PER\nnext O\nmonth O\n. O\n\nThe O\nministry O\nsaid O\nLevy B-PER\nand O\nKinkel B-PER\nwould O\ndiscuss O\nthe O\nMiddle B-LOC\nEast I-LOC\nprocess O\nand O\nGerman-Israeli B-MISC\nrelations O\nat O\ntheir O\nmeeting O\non O\nSeptember O\n9 O\n. O\n\nLevy B-PER\n's O\nvisit O\nwould O\nbe O\nthe O\nfirst O\nby O\nan O\nIsraeli B-MISC\ncabinet O\nminister O\nsince O\nNetanyahu B-PER\n's O\nconservative O\ngovernment O\ntook O\npower O\nin O\nune O\nthis O\nyear O\n, O\nthe O\nministry O\nsaid O\n. O\n\nBefore O\nLevy B-PER\n's O\narrival O\nin O\nBonn B-LOC\n, O\nGerman B-MISC\nDefence O\nMinister O\nVolker B-PER\nRuehe I-PER\nwill O\nvisit O\nIsrael B-LOC\nfrom O\nSeptember O\n2 O\nto O\n4 O\n, O\nthe O\ndefence O\nministry O\nsaid O\n. O\n\nRuehe B-PER\nplanned O\nto O\nmeet O\nhis O\nIsraeli B-MISC\ncounterpart O\nYitzhak B-PER\nMordechai I-PER\nand O\nIsraeli B-MISC\nPresident O\nEzer B-PER\nWeizman I-PER\n, O\nthe O\nministry O\nsaid O\n. O\n\nHe O\nwas O\nalso O\nexpected O\nto O\nmeet O\nPrime O\nMinister O\nNetanyahu B-PER\nand O\nopposition O\nleader O\nShimon B-PER\nPeres I-PER\nfor O\ntalks O\n. O\n\n-DOCSTART- O\n\nFrance B-LOC\nexpels O\nAfrican B-MISC\n, O\nAir B-ORG\nFrance I-ORG\nunions O\nprotest O\n. O\n\nPARIS B-LOC\n1996-08-30 O\n\nFrance B-LOC\non O\nFriday O\nexpelled O\nanother O\nAfrican B-MISC\nman O\nseized O\nin O\na O\npolice O\nraid O\non O\na O\nParis B-LOC\nchurch O\nas O\nabout O\n100 O\nAir B-ORG\nFrance I-ORG\nworkers O\ndenounced O\n\" O\ncharters O\nof O\nshame O\n\" O\nused O\nto O\nfly O\nillegal O\nimmigrants O\nhome O\n. O\n\nA O\nGuinean B-MISC\nman O\n, O\ndetained O\nin O\na O\nround-up O\nin O\nthe O\nSaint-Bernard B-LOC\nchurch O\na O\nweek O\nago O\n, O\nwas O\ndeported O\non O\na O\nscheduled O\nAir B-ORG\nFrance I-ORG\nflight O\nto O\nConakry B-LOC\nafter O\nhis O\nappeals O\nfailed O\n, O\na O\nspokesman O\nfor O\nAir B-ORG\nFrance I-ORG\n's O\npro-Socialist O\nCFDT B-ORG\nunion O\nsaid O\n. O\n\nHe O\nwas O\napparently O\nthe O\neighth O\nAfrican B-MISC\ndeported O\nfrom O\namong O\n210 O\npeople O\nevicted O\nfrom O\nthe O\nchurch O\nafter O\na O\n50-day O\noccupation O\naimed O\nat O\nsecuring O\nresidence O\npermits O\n, O\nunions O\nsaid O\n. O\n\nMost O\nof O\nthe O\nothers O\nhave O\nbeen O\nreleased O\nafter O\na O\nbrief O\nstay O\nin O\ndetention O\n. O\n\nAbout O\n100 O\npeople O\nfrom O\nthe O\nCFDT B-ORG\nand O\nthe O\nCommunist-led B-MISC\nCGT B-ORG\nunions O\nmarched O\noutside O\nAir B-ORG\nFrance I-ORG\nheadquarters O\nat O\nCharles B-LOC\nde I-LOC\nGaulle I-LOC\nairport O\nnorth O\nof O\nParis B-LOC\nagainst O\nthe O\nuse O\nof O\ncivilian O\njets O\nand O\nstaff O\nin O\ndeporting O\nillegal O\nimmigrants O\n. O\n\n\" O\nWe O\nmust O\nobtain O\na O\nformal O\ncommitment O\nfrom O\n( O\nAir B-ORG\nFrance I-ORG\nchairman O\n) O\nChristian B-PER\nBlanc I-PER\nthat O\nno O\nplane O\n, O\nno O\npersonnel O\nbe O\nused O\nto O\ntransform O\nour O\nair O\ncompanies O\ninto O\ncharters O\nof O\nshame O\n, O\n\" O\nCFDT B-ORG\nspokesman O\nFrancois B-PER\nCabrera I-PER\nsaid O\n. O\n\nHe O\nsaid O\ncivilians O\nshould O\nnot O\nbe O\npolice O\naccomplices O\n. O\n\nTwenty-three O\nout O\nof O\n25 O\ncharters O\nflying O\nillegal O\nimmigrants O\nhome O\nsince O\nPrime O\nMinister O\nAlain B-PER\nJuppe I-PER\n's O\ngovernment O\ntook O\noffice O\nin O\nMay O\n1995 O\nhave O\nbeen O\ncivilian O\njets O\n. O\n\nThe O\nother O\ntwo O\nwere O\nmilitary O\njets O\n. O\n\nSeparately O\n, O\nJuppe B-PER\nconfirmed O\nthe O\nconservative O\ngovernment O\nwas O\npreparing O\nto O\nsubmit O\na O\ndraft O\nbill O\nto O\nparliament O\nto O\ntighten O\nlaws O\non O\nillegal O\nworkers O\nas O\npart O\nof O\na O\ncrackdown O\non O\nimmigration O\n. O\n\n\" O\nLegislation O\nis O\ninsufficient O\nin O\nseveral O\nareas O\n, O\nnotably O\nin O\nthose O\nconcerning O\nillegal O\nwork O\n, O\n\" O\nJuppe B-PER\ntold O\nreporters O\n. O\n\n-DOCSTART- O\n\nGerman B-MISC\npolice O\nprobe O\nsex O\nlink O\nin O\nchild O\nkidnap O\ncase O\n. O\n\nBERLIN B-LOC\n1996-08-30 O\n\nGerman B-MISC\npolice O\nsearching O\nfor O\na O\nmissing O\n10-year-old O\nschoolgirl O\nsaid O\non O\nFriday O\nthe O\nprime O\nsuspects O\nin O\nthe O\ncase O\nmay O\nhave O\nbeen O\ninvolved O\nin O\nrunning O\na O\nchild O\nprostitution O\nring O\n. O\n\nPolice O\nsuspect O\nNicole B-PER\nNichterwitz I-PER\n's O\naunt O\nand O\na O\nmale O\ncompanion O\nabducted O\nthe O\ngirl O\nand O\ntook O\nher O\nto O\nthe O\nNetherlands B-LOC\n. O\n\nShe O\nwas O\nlast O\nseen O\nbeing O\ncollected O\nby O\nthe O\npair O\nfrom O\nschool O\nin O\nVelten B-LOC\nnear O\nBerlin B-LOC\non O\nMonday O\n. O\n\nPublic O\nprosecutors O\nsaid O\nthey O\nhad O\nfound O\na O\nlist O\nof O\nchildren O\n's O\nnames O\nand O\nages O\nat O\nthe O\ncouple O\n's O\nflat O\n. O\n\nThe O\nlist O\nwas O\nbeing O\nstudied O\nfor O\npossible O\nlinks O\nto O\nprevious O\nchild O\nkidnappings O\nand O\nprostitution O\n, O\na O\nprosecutors O\n' O\nspokesman O\ntold O\nReuters B-ORG\n. O\n\n-DOCSTART- O\n\nMissing O\nGerman B-MISC\ngirl O\nfound O\nalive O\nat O\nDutch B-MISC\ncampsite O\n. O\n\nGRONINGEN B-LOC\n, O\nNetherlands B-LOC\n1996-08-30 O\n\nDutch B-MISC\npolice O\nsaid O\non O\nFriday O\nthey O\nhad O\nfound O\nmissing O\nGerman B-MISC\ngirl O\nNicole B-PER\nNichterwitz I-PER\nalive O\non O\na O\ncampsite O\nin O\nthe O\nnorthern O\ncity O\nof O\nGroningen B-LOC\nand O\nhad O\narrested O\nher O\naunt O\nand O\ncompanion O\non O\ncharges O\nof O\nkidnapping O\n. O\n\n\" O\nWe O\nhave O\nfound O\nNicole B-PER\non O\na O\ncampsite O\nin O\nGroningen B-LOC\nthanks O\nto O\ntipoffs O\nfrom O\nthe O\nDutch B-MISC\npublic O\n. O\n\nWe O\nhave O\nalso O\nfound O\nand O\narrested O\nher O\naunt O\nand O\ncompanion O\n, O\n\" O\nsaid O\na O\nspokeswoman O\nof O\nthe O\nDutch B-MISC\ncriminal O\ninvestigation O\nservice O\n. O\n\nPolice O\ncould O\nnot O\nyet O\ntell O\nwhether O\nthe O\n10-year-old O\nshowed O\nany O\nsigns O\nof O\nsexual O\nabuse O\n. O\n\n\" O\nWe O\ndo O\nn't O\nknow O\nyet O\n. O\n\nIt O\n's O\ntoo O\nearly O\nto O\ntell O\n, O\n\" O\nshe O\nsaid O\n. O\n\nThe O\ngirl O\nwas O\nabducted O\nfrom O\nher O\nschool O\nin O\nVelten B-LOC\nnear O\nBerlin B-LOC\non O\nMonday O\n. O\n\nGerman B-MISC\npolice O\nsuspected O\nher O\naunt O\n, O\n47 O\n, O\nand O\ncompanion O\n, O\n28 O\n, O\nwere O\ninvolved O\nin O\nrunning O\na O\nchild O\nprostitution O\nring O\n. O\n\nPublic O\nprosecutors O\nsaid O\nthey O\nhad O\nfound O\na O\nlist O\nof O\nchildren O\n's O\nnames O\nand O\nages O\nat O\nthe O\ncouple O\n's O\nflat O\n. O\n\nThe O\nlist O\nwas O\nbeing O\nstudied O\nfor O\npossible O\nlinks O\nto O\nprevious O\nchild O\nkidnappings O\nand O\nprostitution O\n, O\na O\nprosecutors O\n' O\nspokesman O\nsaid O\n. O\n\nThe O\ncouple O\nwould O\nprobably O\nbe O\nextradited O\nto O\nGermany B-LOC\nwhich O\nhas O\nrequested O\ntheir O\ndeportation O\n, O\nthe O\nDutch B-MISC\npolice O\nspokeswoman O\nsaid O\n. O\n\nDescriptions O\nof O\nthe O\ncouple O\n's O\ncar O\nreleased O\nto O\nDutch B-MISC\nmedia O\nled O\nto O\ntheir O\narrest O\n, O\nshe O\nadded O\n. O\n\n-DOCSTART- O\n\nIndian B-MISC\ncopper O\nfalls O\n, O\nstate O\nfirm O\nmay O\ncut O\nrates O\n. O\n\nBOMBAY B-LOC\n1996-08-30 O\n\nIndian B-MISC\ncopper O\nprices O\nfell O\non O\nFriday O\nas O\ndealers O\nawaited O\nan O\nannouncement O\nrelating O\nto O\nprice O\ncuts O\nby O\nstate-owned O\nproducer O\n, O\nHindustan B-ORG\nCopper I-ORG\nLtd I-ORG\n, O\ntraders O\nsaid O\n. O\n\nNickel O\nextended O\ngains O\nwhile O\nother O\nbase O\nmetals O\nwere O\nunchanged O\nin O\nnarrow O\ntrade O\n, O\nthey O\nsaid O\n. O\n\nReady O\ncopper O\nfell O\nby O\n150 O\nrupees O\nat O\n12,350 O\nrupees O\nper O\nquintal O\non O\nfresh O\nofferings O\nby O\nthe O\nstockists O\nwho O\nexpect O\nHindustan B-ORG\nCopper I-ORG\nto O\ncut O\nprices O\n. O\n\nNickel O\nrose O\nby O\n500 O\nto O\n39,200 O\nrupees O\non O\nthin O\nsupply O\nand O\nfresh O\nbuying O\nby O\nstainless O\nsteel O\nmakers O\n. O\n\nTin O\nwas O\nunchanged O\nat O\n36,000 O\nrupees O\n, O\nso O\ndid O\nzinc O\nat O\n6,300 O\nrupees O\nand O\nlead O\nat O\n4,900 O\nrupees O\n. O\n\nAluminium O\nwas O\nquiet O\nat O\n7,450 O\nrupees O\n. O\n\n-- O\nBombay B-ORG\nCommodities I-ORG\n+91-22-265 O\n9000 O\n\n-DOCSTART- O\n\nMARTELA B-ORG\nH1 O\nPROFIT O\nFIM O\n6.3 O\nMLN O\nVS O\n21.0 O\nMLN O\n. O\n\nHELSINKI B-LOC\n1996-08-30 O\n\nSix O\nmonths O\nto O\nJune O\n30 O\n, O\n\n( O\nmillion O\nmarkka O\nunless O\nstated O\n) O\n\nProfit O\nbefore O\nextraordinaries O\n, O\nappropriations O\n, O\n\ntaxes O\n6.3 O\nvs O\n21.0 O\n\nEarnings O\nper O\nshare O\n( O\nmarkka O\n) O\n2.2 O\nvs O\n7.2 O\n\nNet O\nsales O\n289.1 O\nvs O\n256.9 O\n\n-DOCSTART- O\n\nCanadian B-MISC\nbonds O\nopen O\nsofter O\n, O\nspreads O\nto O\nU.S. B-LOC\nshrink O\n. O\n\nTORONTO B-LOC\n1996-08-30 O\n\nCanadian B-MISC\nbonds O\nopened O\nsofter O\non O\nFriday O\n, O\npulled O\nlower O\nby O\na O\nsinking O\nU.S. B-LOC\nmarket O\n, O\nbut O\noutperformed O\nU.S. B-LOC\nbonds O\non O\npositive O\nCanadian B-MISC\neconomic O\ndata O\n, O\nanalysts O\nsaid O\n. O\n\n\" O\nI O\nthink O\nthis O\nmorning O\n's O\nCanadian B-MISC\nnumbers O\nwere O\nvery O\nsupportive O\nof O\nnarrower O\nspreads O\n, O\nparticularly O\nthe O\ncurrent O\naccount O\nnumber O\n, O\n\" O\nsaid O\nJim B-PER\nWebber I-PER\n, O\ndirector O\nof O\nfixed-income O\nresearch O\nwith O\nTD B-ORG\nSecurities I-ORG\nInc I-ORG\n. O\n\nCanada B-LOC\n's O\n8.0 O\npercent O\nbond O\ndue O\n2023 O\nfell O\nC$ B-MISC\n0.45 O\nto O\nC$ B-MISC\n101.15 O\nto O\nyield O\n7.894 O\npercent O\n. O\n\nThe O\nU.S. B-LOC\n30-year O\nbenchmark O\nfell O\n30/32 O\nto O\nyield O\n7.12 O\npercent O\n. O\n\nThe O\nspread O\nbetween O\nbenchmark O\nbonds O\nnarrowed O\n77 O\nbasis O\npoints O\nfrom O\n81 O\nbasis O\npoints O\nat O\nthe O\nclose O\nof O\ntrading O\non O\nWednesday O\n. O\n\nStatistics B-ORG\nCanada I-ORG\non O\nFriday O\nreported O\nCanada B-LOC\n's O\ncurrent O\naccount O\nmoved O\nto O\na O\nhigher-than-expected O\nC$ B-MISC\n1.15 O\nbillion O\nsecond O\nquarter O\nsurplus O\nfrom O\na O\nC$ B-MISC\n1.62 O\nbillion O\ndeficit O\nin O\nthe O\nfirst O\nquarter O\n. O\n\nIt O\nwas O\nthe O\nfirst O\nsurplus O\nsince O\nthe O\nfourth O\nquarter O\nof O\n1984 O\n. O\n\nThe O\nagency O\nalso O\nreported O\nCanada B-LOC\n's O\nreal O\ngross O\ndomestic O\nproduct O\nrose O\na O\nweaker-than-expected O\n0.3 O\npercent O\nin O\nthe O\nsecond O\nquarter O\nor O\n1.3 O\npercent O\nat O\nan O\nannualized O\nrate O\n. O\n\nWhile O\nthe O\ndata O\nprovided O\nsupport O\nfor O\nCanadian B-MISC\nbonds O\n, O\nboth O\nCanadian B-MISC\nand O\nU.S. B-LOC\nmarkets O\nweakened O\nafter O\nthe O\nrelease O\nof O\nstrong O\nU.S. B-LOC\neconomic O\ndata O\n, O\nincluding O\na O\nreport O\nshowing O\nthe O\nChicago B-ORG\nPurchasing I-ORG\nManagers I-ORG\nAugust O\nindex O\nrose O\nto O\n60 O\nfrom O\n51.2 O\nin O\nJuly O\n. O\n\n\" O\nThe O\npurchasing O\nmanagers O\n' O\nnumber O\nis O\nextremely O\n, O\nextremely O\nstrong O\n, O\n\" O\nsaid O\nWebber B-PER\n. O\n\nIn O\nother O\nnews O\n, O\nthe O\nToronto B-ORG\nBond I-ORG\nTraders I-ORG\n' I-ORG\nAssociation I-ORG\nsaid O\nit O\nis O\nrecommending O\nthat O\ndealings O\nin O\nthe O\nCanadian B-MISC\nbond O\nmarket O\nend O\nearly O\nat O\n1400 O\nEDT O\n/ O\n1800 O\nGMT B-MISC\non O\nFriday O\n. O\n\nThe O\nCanadian B-MISC\nmarket O\ntypically O\ncloses O\nearly O\non O\nholiday O\nweekends O\nand O\nCanadian B-MISC\nfinancial O\nmarkets O\nwill O\nbe O\nclosed O\non O\nMonday O\nfor O\nLabour B-MISC\nDay I-MISC\n. O\n\nIn O\nother O\nprices O\n, O\nthe O\n7.0 O\npercent O\nof O\n2006 O\nfell O\nC$ B-MISC\n0.28 O\nto O\nC$ B-MISC\n96.89 O\nto O\nyield O\n7.437 O\npercent O\n. O\n\nThe O\nU.S. B-LOC\n10-year O\nbenchmark O\nfell O\n21/32 O\nto O\nyield O\n6.95 O\npercent O\n. O\n\nThe O\nspread O\nbetween O\nthe O\ntwo O\nbonds O\nnarrowed O\nto O\n49 O\nbasis O\npoints O\nfrom O\n54 O\nbasis O\npoints O\nat O\nthe O\nclose O\nof O\ntrading O\non O\nThursday O\n. O\n\nThe O\nthree-month O\ncash O\nbill O\ntraded O\nat O\n4.04 O\npercent O\nagainst O\nthe O\nU.S. B-LOC\nthree-month O\nbill O\nat O\n5.26 O\npercent O\n. O\n\n-- O\nJeffrey B-PER\nHodgson I-PER\n( O\n416 O\n) O\n941-8105 O\n, O\ne-mail O\n: O\njeffrey.hodgson@reuters.com O\n\n-DOCSTART- O\n\nAw O\nComputer B-ORG\nSystems I-ORG\nInc I-ORG\nQ2 O\nloss O\nwidens O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\n1996 O\n1995 O\n\nShr O\nloss O\n$ O\n0.22 O\nloss O\n$ O\n0.07 O\n\nNet O\nloss O\n1,071 O\nloss O\n277 O\n\nRevs O\n130 O\n1,279 O\n\nAvg O\nshrs O\n4,841 O\n3,990 O\n\nFirst O\nHalf O\n\nShr O\nloss O\n$ O\n0.42 O\nloss O\n$ O\n0.21 O\n\nNet O\nloss O\n1,967 O\nloss O\n841 O\n\nRevs O\n476 O\n2,253 O\n\nAvg O\nshrs O\n4,666 O\n3,944 O\n\n( O\nAll O\nData O\nAbove O\n000s O\nExcept O\nPer O\nShare O\nNumbers O\n) O\n\n-- O\nNew B-ORG\nYork I-ORG\nNewsdesk I-ORG\n212-859-1610 O\n. O\n\n-DOCSTART- O\n\nIPO O\nFILING O\n-- O\nHomegate B-ORG\nHospitality I-ORG\nInc I-ORG\n. O\n\nWASHINGTON B-LOC\n1996-08-30 O\n\nCompany O\nName B-MISC\nHomegate B-ORG\nHospitality I-ORG\nInc I-ORG\n\nNasdaq B-MISC\nStock O\nsymbol O\nHMGT O\n\nEstimated O\nprice O\nrange O\nN O\n/ O\nA O\n\nTotal O\nshares O\nto O\nbe O\noffered O\nN O\n/ O\nA O\n\nShrs O\noffered O\nby O\ncompany O\nN O\n/ O\nA O\n\nShrs O\noutstanding O\nafter O\nipo O\nN O\n/ O\nA O\n\nLead O\nUnderwriter O\nBear B-ORG\nStearns I-ORG\n& I-ORG\nCo I-ORG\nInc I-ORG\n\nUnderwriters O\nover-allotment O\nN O\n/ O\nA O\n\nBusiness O\n: O\nCompany O\n's O\ngoal O\nis O\nto O\nbecome O\na O\nnational O\nprovider O\nof O\nhigh O\nquality O\nextended-stay O\nhotels O\nin O\nstrategically O\nselected O\nmarkets O\nlocated O\nthroughout O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\nUse O\nof O\nProceeds O\n: O\nTo O\nfinance O\nthe O\ndevelopment O\nof O\nadditional O\nextended-stay O\nhotels O\nand O\nother O\ngeneral O\ncorporate O\npurposes O\n. O\n\nFinancial O\nData O\nin O\n000s O\n: O\n1995 O\n1994 O\n\n- O\nRevenue O\nN O\n/ O\nA O\nN O\n/ O\nA O\n\n- O\nNet O\nIncome O\nN O\n/ O\nA O\nN O\n/ O\nA O\n\n-DOCSTART- O\n\nSyria B-LOC\nslams O\nIsrael B-LOC\non O\nsettlements O\n. O\n\nDAMASCUS B-LOC\n1996-08-30 O\n\nSyria B-LOC\non O\nFriday O\ncondemned O\nIsrael B-LOC\n's O\nsettlement O\npolicy O\nand O\nsaid O\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\nwas O\npreparing O\nfor O\nwar O\nwith O\nArabs B-MISC\n. O\n\n\" O\nPractices O\nof O\nthe O\nIsraeli B-MISC\ngovernment O\n, O\nespecially O\nits O\nsettlement O\nactivities O\n, O\ncame O\nto O\nconfirm O\nthat O\ndealing O\nwith O\nthis O\ngovernment O\ninflicts O\nthe O\nbiggest O\nharm O\non O\nthe O\nArab B-MISC\ncause O\n, O\n\" O\nstate-run O\nDamascus B-ORG\nRadio I-ORG\nsaid O\nin O\na O\ncommentary O\n. O\n\n\" O\nWhen O\nthis O\ngovernment O\ninsists O\non O\nstabbing O\nthe O\npeace O\nprocess O\nand O\ntearing O\nit O\napart O\n, O\nthis O\nmeans O\nthat O\nit O\nis O\npreparing O\nfor O\nwar O\n, O\n\" O\nthe O\nradio O\nsaid O\n. O\n\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\ndescribed O\nthis O\nweek O\nthe O\ndecision O\nto O\nexpand O\nsettlements O\nin O\nthe O\nWest B-LOC\nBank I-LOC\nas O\na O\ndeclaration O\nof O\nwar O\n. O\n\nPalestinians B-MISC\nin O\nthe O\nWest B-LOC\nBank I-LOC\nand O\nGaza B-LOC\nobserved O\na O\nstrike O\non O\nThursday O\nto O\nprotest O\nagainst O\nthe O\nIsraeli B-MISC\nmove O\n. O\n\nThe O\nradio O\nurged O\nArabs B-MISC\nto O\nunify O\ntheir O\nranks O\nto O\nthwart O\nthe O\npolicies O\nof O\nthe O\nright-wing O\nIsraeli B-MISC\ngovernment O\n. O\n\n\" O\nIsrael B-LOC\ncould O\nnot O\nconfront O\na O\nunited O\nArab B-MISC\nstand O\nor O\nusurp O\ntheir O\nrights O\nbecause O\nthe O\nArab B-MISC\nrights O\ncould O\nbe O\nregained O\nwhen O\nthey O\nachieve O\nunity O\nand O\nsolidarity O\n, O\n\" O\nDamascus B-LOC\nradio O\nsaid O\n. O\n\nIt O\nwelcomed O\nthe O\ninternational O\ncriticism O\nof O\nIsrael B-LOC\n's O\nsettlement O\npolicies O\nbut O\ncalled O\nfor O\npractical O\nsteps O\nto O\nforce O\nthe O\nIsraeli B-MISC\ngovernment O\nto O\nabandon O\nthis O\npolicy O\n. O\n\n\" O\nIt O\nis O\nimportant O\nto O\ntranslate O\nthe O\ncriticism O\ninto O\npressuring O\naction O\nto O\nprevent O\nIsrael B-LOC\nfrom O\nundermining O\nthe O\nbig O\ninternational O\nefforts O\naimed O\nat O\nmaking O\nthe O\npeace O\nprocess O\nachieve O\nsuccess O\n, O\n\" O\nthe O\nradio O\nsaid O\n. O\n\nSyria B-LOC\nand O\nArabs B-MISC\nhave O\nbeen O\ndismayed O\nby O\nNetanyahu B-PER\n's O\nrefusal O\nto O\ntrade O\nthe O\noccupied O\nArab B-MISC\nlands O\nfor O\npeace O\n, O\nhis O\nsupport O\nfor O\nthe O\nexpansion O\nof O\nsettlements O\nand O\nhis O\ninsistance O\non O\nJerusalem B-LOC\nas O\na O\nunifed O\ncapital O\nfor O\nIsrael B-LOC\n. O\n\nSyria B-LOC\nhas O\nheld O\nsporadic O\npeace O\ntalks O\nwith O\nIsrael B-LOC\nsince O\n1991 O\nwithout O\nachieving O\na O\nbreakthrough O\n. O\n\n-DOCSTART- O\n\nEgypt B-LOC\npolice O\ndetain O\n26 O\nsuspected O\nMoslem B-MISC\nmilitants O\n. O\n\nCAIRO B-LOC\n1996-08-30 O\n\nPolice O\nhave O\ndetained O\n26 O\nsuspected O\nmembers O\nof O\nEgypt B-LOC\n's O\nlargest O\nmilitant O\ngroup O\nal-Gama'a B-ORG\nal-Islamiya I-ORG\n( O\nIslamic B-ORG\nGroup I-ORG\n) O\n, O\ngovernment O\nnewspapers O\nreported O\non O\nFriday O\n. O\n\nThey O\nsaid O\npolice O\narrested O\nthe O\nmilitants O\nin O\nthe O\neastern O\nSharqiyah B-LOC\nprovince O\nafter O\ncapturing O\ntheir O\nleader O\nRami B-PER\nal-Saadani I-PER\nin O\na O\nsatellite O\ncity O\noutside O\nCairo B-LOC\n. O\n\nAl-Akhbar B-ORG\nnewspapers O\nsaid O\nthe O\nmen O\nhad O\nbeen O\nplotting O\nagainst O\n\" O\nstrategic O\ninstitutions O\nand O\nprominent O\nindividuals O\n\" O\nbut O\ngave O\nno O\nother O\ndetails O\n. O\n\nThe O\nnewspapers O\nsaid O\nthe O\nmen O\nwere O\nbeing O\ninterrogated O\n. O\n\nState O\nsecurity O\nofficials O\nwere O\nnot O\nimmediately O\navailable O\nfor O\ncomment O\n. O\n\nMore O\nthan O\n960 O\npeople O\nhave O\nbeen O\nkilled O\nin O\nthe O\narmed O\nstruggle O\nthe O\nGama'a B-MISC\nlaunched O\nin O\n1992 O\nto O\ntopple O\nPresident O\nHosni B-PER\nMubarak I-PER\n's O\ngovernment O\nand O\nestablish O\na O\npurist O\nIslamic B-MISC\nstate O\nin O\nits O\nplace O\n\n-DOCSTART- O\n\nIsrael B-LOC\nblocks O\nPalestinian B-MISC\npilgrims O\n' O\nprogress O\n. O\n\nSami B-PER\nAboudi I-PER\n\nAL-RAM B-LOC\n, O\nWest B-LOC\nBank I-LOC\n1996-08-30 O\n\nKamil B-PER\nJamil I-PER\ndid O\nn't O\nhave O\na O\nprayer O\n. O\n\nAn O\nIsraeli B-MISC\nroadblock O\nstopped O\nthe O\n38-year-old O\nPalestinian B-MISC\nfrom O\nanswering O\nYasser B-PER\nArafat I-PER\n's O\ncall O\nto O\nworship O\nat O\nJerusalem B-LOC\n's O\nal-Aqsa B-LOC\nmosque O\non O\nFriday O\n. O\n\n\" O\nGo O\nhome O\n. O\n\nThere O\nare O\nno O\nprayers O\ntoday O\n, O\n\" O\nan O\nIsraeli B-MISC\nsoldier O\nyelled O\nat O\nJamil B-PER\nin O\nHebrew B-MISC\n. O\n\nPalestinian B-MISC\nPresident O\nArafat B-PER\n, O\nattacking O\nIsrael B-LOC\n's O\ndecision O\nto O\nexpand O\nJewish B-MISC\nsettlements O\nand O\nits O\npolicy O\non O\nJerusalem B-LOC\n, O\nwent O\nbefore O\nthe O\nPalestinian B-MISC\nlegislature O\non O\nWednesday O\nto O\nurge O\nthe O\ntwo O\nmillion O\nArabs B-MISC\nin O\nthe O\nWest B-LOC\nBank I-LOC\nand O\nGaza B-LOC\nto O\ngo O\nto O\nthe O\nholy O\ncity O\n. O\n\nPilgrims O\nstood O\nlittle O\nchance O\nof O\nmaking O\nprogress O\n. O\n\nPalestinians B-MISC\nhave O\nbeen O\nbanned O\nby O\nIsrael B-LOC\nfrom O\ntravelling O\nfrom O\nthe O\nWest B-LOC\nBank I-LOC\nto O\nJerusalem B-LOC\nsince O\nsuicide O\nbombings O\nby O\nMoslem B-MISC\nmilitants O\nkilled O\n59 O\npeople O\nin O\nthe O\nJewish B-MISC\nstate O\nin O\nFebruary O\nand O\nMarch O\n. O\n\nAnd O\nIsraeli B-MISC\ncheckpoints O\nhave O\ncircled O\nJerusalem B-LOC\nsince O\n1993 O\n, O\na O\nconcrete O\nand O\nconstant O\nreminder O\nof O\nIsrael B-LOC\n's O\nhold O\non O\na O\ncity O\nit O\nconsiders O\nits O\neternal O\ncapital O\n. O\n\nThe O\nPLO B-ORG\nwants O\nArab B-LOC\nEast I-LOC\nJerusalem I-LOC\nas O\nthe O\ncapital O\nof O\na O\nfuture O\nPalestinian B-MISC\nstate O\n. O\n\nOnly O\na O\nfew O\nPalestinians B-MISC\ntrickled O\nto O\nthe O\nroadblocks O\n. O\n\nThey O\nwere O\nimmediately O\nturned O\nback O\n. O\n\n\" O\nI O\nam O\nheeding O\nAbu B-PER\nAmmar I-PER\n's O\n( O\nArafat B-PER\n's O\n) O\ncall O\nto O\npray O\nat O\nal-Aqsa B-LOC\nand O\nI O\ncame O\n. O\n\nIt O\nis O\nour O\nduty O\ntowards O\nal-Aqsa B-LOC\nto O\ncome O\nand O\npray O\n, O\n\" O\nJamil B-PER\nsaid O\n. O\n\nA O\ntourist O\nfrom O\nJordan B-LOC\nwas O\nalso O\ntold O\nby O\nIsraeli B-MISC\nsoldiers O\nat O\nthe O\nal-Ram B-LOC\ncheckpoint O\nthat O\nhe O\ncould O\nnot O\nenter O\nJerusalem B-LOC\n. O\n\n\" O\nWe O\nhave O\na O\npeace O\ntreaty O\nwith O\nthem O\nand O\nwe O\nlet O\nthem O\ngo O\nwherever O\nthey O\nwant O\nwhen O\nthey O\ncome O\nto O\nJordan B-LOC\n, O\n\" O\nsaid O\nthe O\ntourist O\n, O\nKhaled B-PER\nHijazi I-PER\n, O\n37 O\n. O\n\" O\n\nI O\nfeel O\nterrible O\n. O\n\nI O\nam O\nentitled O\nto O\nsee O\nJerusalem B-LOC\n, O\n\" O\nhe O\nsaid O\n. O\n\nSome O\nPalestinians B-MISC\ntook O\nto O\nback O\nroads O\n, O\nonly O\nto O\nrun O\ninto O\nwaiting O\nIsraeli B-MISC\nsecurity O\nforces O\n. O\n\n\" O\nThe O\nIsraelis B-MISC\nhave O\nno O\nright O\nto O\nprevent O\nus O\nfrom O\ngoing O\nto O\npray O\n. O\n\nWhat O\nkind O\nof O\npeace O\nis O\nthis O\nthat O\nprevents O\nus O\nfrom O\nreaching O\nour O\nholy O\nplaces O\n? O\n\" O\n\nasked O\nMustafa B-PER\nHoshiyeh I-PER\n, O\na O\n27-year-old O\nWest B-LOC\nBank I-LOC\nlabourer O\nturned O\naround O\nby O\na O\npolice O\npatrol O\non O\na O\nback O\nroad O\n. O\n\n\" O\nAbu B-PER\nAmmar I-PER\n( O\nArafat B-PER\n) O\nis O\nright O\n. O\n\nWe O\nhave O\nsigned O\na O\npeace O\ntreaty O\nwith O\nthe O\nIsraelis B-MISC\nbut O\non O\nthe O\nground O\n, O\nwe O\nsee O\nthat O\nnothing O\nhas O\nchanged O\n, O\n\" O\nsaid O\n20-year-old O\nAli B-PER\nAhmed I-PER\nfrom O\nQalandia B-LOC\nrefugee O\ncamp O\n. O\n\n-DOCSTART- O\n\nPRESALE O\n- O\nBay B-ORG\nCo I-ORG\nBldg I-ORG\nAuth I-ORG\n, O\nMich B-LOC\n.. O\n\nAMT O\n: O\n1,200,000 O\nDATE O\n: O\n09/05/96 O\nNYC B-MISC\nTime O\n: O\n1600 O\nCUSIP O\n: O\n072261 O\n\nISSUER O\n: O\nBay B-ORG\nCo I-ORG\nBuilding I-ORG\nAuthority I-ORG\nST O\n: O\nMI B-LOC\n\nISSUE O\n: O\nBldg O\nauth O\n( O\nlaw O\nenforcement O\nctr O\n) O\nSeries O\n1996-A O\nTAX O\nSTAT O\n: O\nExempt-REV O\n\nM O\n/ O\nSP O\n/ O\nF O\n: O\nNA O\n/ O\nNA O\n/ O\nNA O\nBOOK O\nENTRY O\n: O\nN O\n\nENHANCEMENTS O\n: O\nNone O\nBANK O\nQUAL O\n: O\nY O\n\nDTD O\n: O\n09/01/96 O\nSURE O\nBID O\n: O\nY O\n\nDUE O\n: O\n11/1/96-11 O\nSR O\nMGR O\n: O\n\n1ST O\nCPN O\n: O\n11/01/96 O\n\nCALL O\n: O\n11/1/05 O\n@ O\n101 O\n, O\ndtp O\n11/1/07 O\nNIC O\n\nDELIVERY O\n: O\n45 O\ndays O\napprox O\nORDERS O\n: O\n\nPAYING O\nAGENT O\n: O\nMichigan B-ORG\nNational I-ORG\nBank I-ORG\n, O\nDetroit B-LOC\n\nL.O. O\n: O\nBodman B-ORG\n, I-ORG\nLongely I-ORG\n& I-ORG\nDahling I-ORG\n, O\nDetroit B-LOC\n\nF.A. O\n: O\nFirst B-ORG\nof I-ORG\nMichigan I-ORG\nCorp. I-ORG\n, O\nDetroit B-LOC\n\nLAST O\nSALE O\n: O\nNone O\n\nYear O\nAmount O\nCoupon O\nYield O\nPrice O\nConc O\n. O\n\n1996 O\n45,000 O\n\n1997 O\n50,000 O\n\n1998 O\n55,000 O\n\n1999 O\n55,000 O\n\n2000 O\n60,000 O\n\n2001 O\n65,000 O\n\n2002 O\n70,000 O\n\n2003 O\n70,000 O\n\n2004 O\n75,000 O\n\n2005 O\n80,000 O\n\n2006 O\n85,000 O\n\n2007 O\n90,000 O\n\n2008 O\n90,000 O\n\n2009 O\n95,000 O\n\n2010 O\n105,000 O\n\n2011 O\n110,000 O\n\nCOMPETITIVE O\nPRE-SALE O\nCONTRIBUTED O\nBY O\nJ.J. B-ORG\nKENNY I-ORG\nK-SHEETS O\n: O\n\n-DOCSTART- O\n\nConsumer O\nspending O\n, O\nincomes O\nedge O\nup O\nin O\nJuly O\n. O\n\nGlenn B-PER\nSomerville I-PER\n\nWASHINGTON B-LOC\n1996-08-30 O\n\nConsumer O\nspending O\nbarely O\nedged O\nup O\nin O\nJuly O\n, O\nthe O\nCommerce B-ORG\nDepartment I-ORG\nsaid O\nFriday O\n, O\nas O\nincome O\ngrowth O\nslowed O\nabruptly O\nto O\nthe O\nweakest O\npace O\nin O\nsix O\nmonths O\n. O\n\nSpending O\nrose O\n0.2 O\npercent O\nto O\na O\nseasonally O\nadjusted O\nannual O\nrate O\nof O\n$ O\n5.15 O\ntrillion O\nafter O\ndropping O\na O\nrevised O\n0.4 O\npercent O\nin O\nJune O\n. O\n\nIncomes O\nfrom O\nwages O\n, O\nsalaries O\nand O\nall O\nother O\nsources O\ngained O\n0.1 O\npercent O\nto O\na O\nrate O\nof O\n$ O\n6.47 O\ntrillion O\nafter O\na O\n0.9 O\npercent O\njump O\nin O\nJune O\n. O\n\nDepartment O\nofficials O\nsaid O\nJuly O\n's O\nslight O\ngain O\nin O\nincomes O\nwas O\nthe O\nweakest O\nfor O\nany O\nmonth O\nsince O\nJanuary O\n, O\nwhen O\nthey O\nwere O\nflat O\n. O\n\nWages O\nand O\nsalaries O\ncame O\nunder O\npressure O\nin O\nJuly O\nas O\na O\nshorter O\naverage O\nworkweek O\nand O\nlower O\nhourly O\nearnings O\ncut O\ninto O\npaychecks O\n. O\n\nThe O\ndepartment O\nsaid O\nwages O\nand O\nsalaries O\ndecreased O\nby O\n$ O\n6.9 O\nbillion O\nin O\nJuly O\nafter O\nclimbing O\n$ O\n45 O\nbillion O\nin O\nJune O\n. O\n\n\" O\nIn O\nJuly O\n, O\naverage O\nweekly O\nhours O\nand O\naverage O\nhourly O\nearnings O\ndeclined O\n, O\nmore O\nthan O\noffsetting O\nthe O\neffect O\nof O\nan O\nincrease O\nin O\nemployment O\n, O\n\" O\nCommerce B-ORG\nsaid O\n. O\n\nBut O\nmore O\nmoney O\nwent O\ninto O\nsavings O\naccounts O\n, O\nas O\nsavings O\nheld O\nat O\n5.3 O\ncents O\nout O\nof O\neach O\ndollar O\nearned O\nin O\nboth O\nJune O\nand O\nJuly O\n. O\n\nThat O\nwas O\nthe O\nhighest O\nsavings O\nrate O\nsince O\nOctober O\nlast O\nyear O\n, O\nwhen O\n5.5 O\ncents O\nout O\nof O\neach O\ndollar O\nearned O\nwas O\nbeing O\nsaved O\n. O\n\nThe O\ngenerally O\nlackluster O\nreport O\non O\nspending O\nand O\nincomes O\nin O\nJuly O\nhad O\nbeen O\nexpected O\n. O\n\nAt O\nthe O\nsame O\ntime O\n, O\nthe O\ndepartment O\nsaid O\nin O\na O\nseparate O\nreport O\nthat O\nnew O\norders O\nreceived O\nby O\nU.S. B-LOC\nfactories O\nclimbed O\nstrongly O\nin O\nJuly O\n, O\nwith O\nwidespread O\ngains O\nacross O\nmost O\nmajor O\ncategories O\n. O\n\nOrders O\nincreased O\n1.8 O\npercent O\nto O\na O\nseasonally O\nadjusted O\n$ O\n317.6 O\nbillion O\n, O\nsignificantly O\nstronger O\nthan O\nthe O\n1 O\npercent O\nrise O\nforecast O\nby O\nWall B-LOC\nStreet I-LOC\neconomists O\n. O\n\nThat O\nfollowed O\na O\nrevised O\n0.7 O\npercent O\ndecline O\nin O\nJune O\norders O\n. O\n\nCommerce O\nsaid O\npreviously O\nthat O\nspending O\nat O\nretail O\nstores O\nwas O\nup O\nonly O\n0.1 O\npercent O\nin O\nJuly O\n, O\npartly O\nbecause O\nof O\nsofter O\nsales O\nof O\nnew O\ncars O\nand O\nlight O\ntrucks O\n. O\n\nIn O\naddition O\n, O\nthe O\nLabour B-ORG\nDepartment I-ORG\n's O\nJuly O\nemployment O\nreport O\nhad O\nforeshadowed O\nthe O\nmuted O\nincome O\ngrowth O\n. O\n\nIt O\nshowed O\naverage O\nhourly O\nearnings O\nfell O\nin O\nJuly O\nby O\n0.2 O\npercent O\nto O\n$ O\n11.00 O\nand O\nthe O\naverage O\nworkweek O\nshortened O\nto O\n34.3 O\nhours O\nfrom O\n34.7 O\nin O\nJune O\n. O\n\nGains O\nin O\npersonal O\nincome O\n, O\nwhich O\nincludes O\nwages O\nand O\nsalaries O\nas O\nwell O\nas O\nincome O\nfrom O\nsources O\nsuch O\nas O\ndividends O\n, O\ninterest O\nand O\nbusinesses O\n, O\nare O\nessential O\nfor O\nfunding O\nconsumer O\npurchases O\n, O\nwhich O\nfuel O\ntwo-thirds O\nof O\nnational O\neconomic O\nactivity O\n. O\n\nSpending O\non O\nall O\ntypes O\nof O\ndurable O\ngoods O\n, O\nwhich O\nincludes O\ncars O\n, O\nfell O\nto O\nan O\nannual O\nrate O\nof O\n$ O\n626.3 O\nbillion O\nin O\nJuly O\nfrom O\n$ O\n633.6 O\nbillion O\nin O\nJune O\n. O\n\nBut O\nspending O\non O\nnondurable O\nproducts O\nincreased O\nmoderately O\nto O\na O\nrate O\nof O\n$ O\n1.55 O\ntrillion O\nfrom O\n$ O\n1.54 O\ntrillion O\nin O\nJune O\n, O\nwhile O\nspending O\nfor O\nservices O\nwas O\nup O\nto O\n$ O\n2.97 O\ntrillion O\nin O\nJuly O\nfrom O\n$ O\n2.96 O\ntrillion O\n. O\n\nPayrolls O\nof O\nmanufacturing O\ncompanies O\nrose O\nin O\nJuly O\nby O\n$ O\n2.3 O\nbillion O\nto O\nan O\nannual O\nrate O\nof O\n$ O\n678 O\nbillion O\n. O\n\n-DOCSTART- O\n\nWorld O\nMarkets O\nOvernight O\nSummary O\n- O\nAug O\n30 O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nWORLD O\nMARKETS O\nROUND-UP O\n\nSTOCKS O\nGOLD O\nMETALS O\n\nNY B-MISC\nDow I-MISC\nclose O\nLondon B-LOC\nopening O\nLME B-ORG\nclose O\n\n5647.65 O\n( O\n- O\n64.73 O\n) O\n$ O\n387.70 O\ncopper O\nper O\ntonne O\n\nNikkei B-MISC\nlatest O\nCRUDE O\nOIL O\n$ O\n1987.0 O\n\n20202.87 O\n( O\n- O\n350.29 O\n) O\nSept O\nBrent B-ORG\nzinc O\nper O\ntonne O\n\nFTSE B-MISC\nclose O\n$ O\n21.25 O\n$ O\n1000.0 O\n\n3885.0 O\n( O\n- O\n33.7 O\n) O\n\n----- O\noOo----- O\n\nSTOCKS O\nSINK O\nAS O\nBOND O\nRATES O\nJUMP O\nON O\nSTRONG O\nDATA O\n\nBlue-chip O\nstocks O\nsank O\nto O\ntheir O\nbiggest O\nloss O\nsince O\nmid-July O\nThursday O\nas O\nfresh O\nsigns O\nof O\na O\nsurprisingly O\nstrong O\neconomy O\nboosted O\nlong-term O\nbond O\ninterest O\nrates O\nabove O\n7 O\npercent O\n. O\n\nThe O\ndollar O\nrose O\nslightly O\nagainst O\nthe O\nGerman B-MISC\nmark O\n, O\nbut O\nedged O\nlower O\nagainst O\nthe O\nJapanese B-MISC\nyen O\n. O\n\nThe O\nDow B-MISC\nJones I-MISC\nindustrial O\naverage O\nended O\ndown O\n64.73 O\npoints O\nat O\n5,647.65 O\n, O\nits O\nlargest O\ndrop O\nsince O\nJuly O\n15 O\n, O\nwhen O\nit O\nclosed O\nwith O\na O\nloss O\nof O\n161 O\npoints O\n. O\n\nIn O\nthe O\nbroader O\nmarket O\n, O\ndeclining O\nissues O\nbeat O\nadvances O\n1,627 O\nto O\n743 O\non O\nmoderate O\nvolume O\nof O\n321 O\nmillion O\nshares O\non O\nthe O\nNew B-ORG\nYork I-ORG\nStock I-ORG\nExchange I-ORG\n. O\n\nIn O\nthe O\nbond O\nmarket O\n, O\nthe O\n30-year O\nTreasury B-ORG\nbond O\nfell O\n23/32 O\nof O\na O\npoint O\n, O\nor O\n$ O\n7.1875 O\non O\na O\n$ O\n1,000 O\nbond O\n, O\nraising O\nits O\nyield O\nto O\n7.04 O\npercent O\n-- O\nthe O\nhighest O\nsince O\nJuly O\n31 O\n-- O\nfrom O\n6.98 O\npercent O\nat O\nWednesday O\n's O\nclose O\n. O\n\n\" O\nSeven O\npercent O\ncreates O\npsychological O\nproblems O\nand O\na O\nlegitimate O\ncompetitor O\nfor O\nmoney O\nfrom O\nequities O\n, O\n\" O\nsaid O\nRalph B-PER\nBloch I-PER\n, O\nchief O\ntechnical O\nanalyst O\nat O\nRaymond B-PER\nJames I-PER\n. O\n\n\" O\nWe O\ncould O\ncarry O\nanother O\n100 O\npoints O\nlower O\nin O\nthe O\nDow B-MISC\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nI O\n'm O\ntelling O\nclients O\nthings O\nare O\ndicey O\ngoing O\ninto O\nnext O\nFriday O\n( O\nSept O\n. O\n\n6 O\n) O\nso O\nlet O\n's O\nbe O\ncareful O\n. O\n\" O\n\nWall B-LOC\nStreet I-LOC\non O\nSept O\n. O\n\n6 O\nfaces O\nthe O\nkey O\nmonthly O\nemployment O\nreport O\n, O\nwhich O\nhas O\nbeen O\nknown O\nto O\ncause O\ndramatic O\nswings O\nin O\nstock O\nprices O\n. O\n\n\" O\nWe O\nhad O\ntwo O\nvery O\nstrong O\neconomic O\nreports O\n, O\n\" O\nsaid O\nDavid B-PER\nShulman I-PER\n, O\nSalomon B-ORG\nBros I-ORG\n. I-ORG\n' O\n\nchief O\nequity O\nstrategist O\n. O\n\" O\n\nThere O\nare O\nmore O\nworries O\nin O\nbond O\nland O\n. O\n\nFears O\nof O\na O\nFed B-ORG\ntightening O\nnext O\nmonth O\nhave O\nresurfaced O\nfor O\nthe O\nfirst O\ntime O\nsince O\nthe O\nend O\nof O\nJuly O\n. O\n\" O\n\nThe O\nCommerce B-ORG\nDepartment I-ORG\nreported O\nthat O\nthe O\nnation O\n's O\ngross O\ndomestic O\nproduct O\nexpanded O\nat O\na O\n4.8 O\npercent O\nannual O\nrate O\nin O\nthe O\nthree O\nmonths O\nfrom O\nApril O\nthrough O\nJune O\ninstead O\nof O\nthe O\n4.2 O\npercent O\nestimated O\na O\nmonth O\nago O\n. O\n\nIn O\nanother O\nreport O\n, O\nsales O\nof O\nnew O\nhomes O\njumped O\nunexpectedly O\nin O\nJuly O\nto O\nthe O\nbriskest O\nrate O\nin O\nfive O\nmonths O\n, O\ndriving O\nprices O\nup O\nin O\na O\nstrong O\nhousing O\nmarket O\n. O\n\nSales O\nshot O\nup O\n7.9 O\npercent O\nlast O\nmonth O\nto O\na O\nseasonally O\nadjusted O\nannual O\nrate O\nof O\n783,000 O\nunits O\n-- O\nthe O\nstrongest O\nsince O\nFebruary O\n, O\nwhen O\nnew O\nhomes O\nwere O\nselling O\nat O\na O\nrate O\nof O\n784,000 O\na O\nyear O\n. O\n\nAnalysts O\nsaid O\nthe O\nstock O\nmarket O\nwas O\nalso O\nworried O\nabout O\nthe O\nimpact O\non O\nPresident O\nClinton B-PER\n's O\nre-election O\nbid O\nof O\nhis O\ntop O\npolitical O\nstrategist O\nresigning O\n. O\n\nDick B-PER\nMorris I-PER\n, O\nwho O\nis O\ncredited O\nwith O\nresurrecting O\nClinton B-PER\n's O\npolitical O\nfortunes O\nover O\nthe O\npast O\n18 O\nmonths O\nby O\nmasterminding O\nhis O\nturn O\nto O\nthe O\npolitical O\ncentre O\n, O\nquit O\nafter O\na O\nsupermarket O\ntabloid O\nreported O\nhe O\nengaged O\nin O\na O\nyearlong O\naffair O\nwith O\na O\nprostitute O\n, O\nwith O\nwhom O\nhe O\nallegedly O\nshared O\nconfidential O\ncampaign O\ndocuments O\n. O\n\nAnalysts O\nsaid O\nWall B-LOC\nStreet I-LOC\nhad O\ngrown O\naccustomed O\nto O\na O\nmoderate O\nRepublican B-MISC\nin O\nthe O\nform O\nof O\nDemocratic B-MISC\nPresident O\nClinton B-PER\n. O\n\nMorris B-PER\n' O\ndeparture O\nraised O\nfears O\nthat O\nClinton B-PER\nwould O\nveer O\nmore O\nto O\nthe O\nleft O\nin O\na O\nsecond O\nterm O\n. O\n\nThe O\ndollar O\nclosed O\nat O\n1.4772 O\nmarks O\n, O\nup O\nfrom O\n1.4767 O\nlate O\nWednesday O\n. O\n\nThe O\ndollar O\nslipped O\nto O\n108.40 O\nyen O\nfrom O\n108.45 O\n. O\n\nOil O\nmarkets O\nrose O\nsharply O\non O\na O\ncombination O\nof O\nlow O\nstocks O\n, O\ntwo O\nhurricanes O\nand O\nallegations O\nof O\nillicit O\ntrading O\nby O\nIraq B-LOC\n. O\n\nSeptember O\nheating O\noil O\non O\nthe O\nNew B-ORG\nYork I-ORG\nMercantile I-ORG\nExchange I-ORG\nclosed O\n1.63 O\ncents O\nhigher O\nat O\n63.67 O\ncents O\na O\ngallon O\n, O\nSeptember O\nunleaded O\ngasoline O\nfinished O\n1.39 O\ncents O\nup O\nat O\n63.72 O\ncents O\na O\ngallon O\nand O\nOctober O\ncrude O\nrose O\n44 O\ncents O\nto O\n$ O\n22.15 O\na O\nbarrel O\n. O\n\nDecember O\ncotton O\nclosed O\n0.95 O\ncent O\nhigher O\nat O\n77.06 O\ncents O\nper O\npound O\non O\nthe O\nNew B-ORG\nYork I-ORG\nCotton I-ORG\nExchange I-ORG\ndespite O\nsome O\neasing O\nof O\nconcern O\nabout O\nthe O\ntwin O\nhurricane O\nthreat O\nto O\nkey O\nU.S. B-LOC\ngrowing O\nareas O\nwith O\nforecasts O\nindicating O\nboth O\nstorms O\nmay O\nremain O\noffshore O\n. O\n\nOverseas O\n, O\nLondon B-LOC\n's O\nFTSE B-MISC\n100 I-MISC\nindex O\nhad O\nearlier O\nclimbed O\nto O\n3,8921.1 O\njust O\nbelow O\nits O\nrecord O\nof O\n3,922.1 O\n, O\nbefore O\nedging O\ndown O\nthrough O\nthe O\nafternoon O\nsession O\nto O\nfinish O\nthe O\nday O\nat O\n3,885.0 O\n, O\na O\nfall O\nof O\n33.7 O\npoints O\n. O\n\nIn O\nTokyo B-LOC\n, O\nthe O\nkey O\n225-share O\nNikkei B-MISC\naverage O\nshed O\n156.65 O\npoints O\n, O\nor O\n0.76 O\npercent O\n, O\nto O\nend O\nat O\n20,553.16 O\n. O\n\n-DOCSTART- O\n\nPirelli B-ORG\ncables O\nlook O\nto O\ntap O\nChinese B-MISC\ngrowth O\n. O\n\nDavid B-PER\nJones I-PER\n\nMILAN B-LOC\n1996-08-30 O\n\nItalian B-MISC\ntyre O\nand O\ncables O\ngiant O\nPirelli B-ORG\non O\nFriday O\nannounced O\nits O\nlong-awaited O\nmove O\ninto O\nChina B-LOC\nwith O\na O\ncables O\njoint O\nventure O\nset O\nto O\ncapitalise O\non O\nthe O\nrapidly-growing O\nChinese B-MISC\ntelecommunications O\nmarket O\n. O\n\nPirelli B-ORG\nis O\nlinking O\nwith O\nHong B-MISC\nKong-based I-MISC\ngroup O\nCITIC B-ORG\nPacific I-ORG\nin O\na O\nventure O\nto O\nbe O\ncalled O\nthe O\nWuxi B-ORG\nTong I-ORG\nLing I-ORG\nCompany I-ORG\nLtd I-ORG\n, O\nwhich O\nwill O\noperate O\nin O\npartnership O\nwith O\na O\nlocal O\nindustrial O\ncompany O\nat O\nits O\nexisting O\nfactory O\nin O\nWuxi B-LOC\n, O\nJiangsu B-LOC\nprovince O\n, O\nShanghai B-LOC\n. O\n\nThe O\npartners O\nwill O\ninvest O\naround O\n$ O\n30 O\nmillion O\nin O\nthe O\nexisting O\ncopper O\ncable O\nplant O\nat O\nWuxi B-LOC\nto O\nupdate O\ntechnology O\nand O\ninclude O\noptic O\nfibre O\nproduction O\n, O\nwith O\nannual O\nturnover O\nexpected O\nto O\nreach O\n$ O\n60 O\nmillion O\nwithin O\nthe O\nnext O\nfew O\nyears O\n. O\n\nThe O\nmove O\nmarks O\na O\nfurther O\nmove O\nby O\nPirelli B-ORG\n's O\ncables O\ndivision O\nto O\nexpand O\nin O\nthe O\nfast-growing O\nFar B-MISC\nEastern I-MISC\ndeveloping O\nmarkets O\nwith O\nthe O\ngroup O\nalready O\npresent O\nin O\nIndonesia B-LOC\n, O\nIndia B-LOC\nand O\nMalaysia B-LOC\n. O\n\n\" O\nThis O\nis O\nreally O\npositive O\nnews O\nfor O\nPirelli B-ORG\n, O\nand O\nI O\nexpect O\nthat O\nit O\nwill O\nproduce O\none O\nof O\nthe O\nbest O\nhalf-year O\nresults O\nin O\nlate O\nSeptember O\ncompared O\nto O\nother O\nindustrial O\nItalian B-MISC\ncompanies O\n, O\n\" O\nsaid O\nanalyst O\nPaula B-PER\nBuratti I-PER\nat O\nIndosuez B-ORG\n. O\n\nShe O\nemphasised O\nthat O\nthe O\nmove O\nwas O\npositive O\nbecause O\nPirelli B-ORG\nwill O\nhave O\nmanagement O\ncontrol O\nof O\nthe O\nChinese B-MISC\nventure O\n, O\nand O\nit O\nalso O\nshowed O\nanother O\nexample O\nof O\nPirelli B-ORG\nexporting O\nits O\ntechnical O\nknow-how O\nto O\ndeveloping O\nmarkets O\n. O\n\nPirelli B-ORG\nshares O\nreacted O\nfavourable O\neven O\nthough O\ntalks O\nhad O\nbeen O\nunderway O\nfor O\nsome O\ntime O\nand O\nnews O\nabout O\na O\nventure O\nhad O\nbeen O\nwidely O\nexpected O\n. O\n\nThe O\nshares O\nrose O\n0.2 O\npercent O\nto O\n2,555 O\nlire O\nby O\n1350 O\nGMT B-MISC\nin O\nan O\neasier O\nMilan B-LOC\nstock O\nmarket O\n. O\n\nThis O\nwill O\nbe O\nPirelli B-ORG\n's O\nfirst O\nindustrial O\ninvolvement O\nin O\na O\nChinese B-MISC\nmarket O\nwhere O\ndemand O\nfor O\ntelecommunication O\nnetworks O\nis O\nexpected O\nto O\ngrow O\nto O\n80-100 O\nmillion O\nnew O\nlines O\nbetween O\n1996 O\nand O\n2000 O\n, O\ndoubling O\ndemand O\nfor O\noptical O\ncables O\n. O\n\nChina B-LOC\n's O\nsecond O\nlargest O\ntelecoms O\noperator O\nUnicom B-ORG\nalready O\nhas O\na O\nmandate O\nfrom O\nthe O\ncentral O\ngovernment O\nto O\nestablish O\n15 O\nmillion O\nnew O\nphone O\nlines O\nby O\nthe O\nyear O\n2000 O\n, O\nwhich O\nwill O\nnecessitate O\nnew O\ntrunk O\nline O\nsystems O\nand O\nlocal O\ndistribution O\nnetworks O\n. O\n\n\" O\nThe O\nstarting O\nof O\nthis O\nproduction O\nbase O\nin O\nChina B-LOC\nhas O\nfor O\nour O\ngroup O\nan O\nundoubted O\nstrategic O\nvalue O\n, O\nrepresenting O\nan O\nimportant O\nenhancement O\nof O\nour O\npresence O\nin O\nAsia B-LOC\n, O\n\" O\nsaid O\nPirelli B-ORG\nSpA I-ORG\nchairman O\nand O\nchief O\nexecutive O\nofficer O\nMarco B-PER\nTonchetti I-PER\nProvera I-PER\n. O\n\nPirelli B-ORG\nCables I-ORG\nhas O\nglobal O\nsales O\nof O\nover O\n$ O\n3.5 O\nbillion O\n, O\nand O\nhas O\nbecome O\na O\nlarge O\nsupplier O\nof O\noptic O\ncables O\nand O\nsystems O\nto O\nmajor O\ntelecoms O\ncarriers O\nin O\nthe O\nU.S. B-LOC\n, O\nEurope B-LOC\nand O\nthe O\nFar B-LOC\nEast I-LOC\n. O\n\nCITIC B-ORG\nPacific I-ORG\nis O\na O\nmajor O\nHong B-MISC\nKong-listed I-MISC\ncompany O\nfocusing O\non O\ninfrastruture O\n, O\ntrading O\n, O\ndistribution O\nand O\nproperty O\n, O\nwith O\n28 O\npercent O\nof O\nits O\n1995 O\nprofits O\ncoming O\nfrom O\ntelecoms O\n. O\n\nIt O\nhas O\ninvestments O\nin O\nseveral O\nindustrial O\njoint O\nventures O\nin O\nChina B-LOC\n. O\n\n-DOCSTART- O\n\nDutch B-MISC\nbond O\nfutures O\nrevival O\ndelayed O\n- O\nEOE B-ORG\n. O\n\nAMSTERDAM B-LOC\n1996-08-30 O\n\nA O\nbroad O\nattempt O\nto O\nspur O\nactivity O\nin O\nDutch B-MISC\nbond O\nfutures O\nhas O\nbeen O\ndelayed O\nto O\ngive O\nparticipants O\na O\nchance O\nto O\nbecome O\nfamiliar O\nwith O\nthe O\ntrading O\nsystem O\n, O\nthe O\nEuropean B-ORG\nOptions I-ORG\nExchange I-ORG\n( O\nEOE B-ORG\n) O\nsaid O\non O\nFriday O\n. O\n\nMarket-making O\nin O\nthe O\nrarely-traded O\nFTO B-ORG\ncontract O\nwas O\nexpected O\nto O\nbegin O\ntoday O\n, O\nbut O\nan O\nEOE B-ORG\nspokesman O\nsaid O\nthe O\n10 O\nbanks O\nand O\nbrokers O\ninvolved O\nin O\nthe O\ninitiative O\nneeded O\ntime O\nto O\nget O\naccustomed O\nto O\nchanges O\nin O\nthe O\nelectronic O\ntrading O\nsystem O\n. O\n\n\" O\nIt O\n's O\nnot O\nready O\nyet O\n. O\n\nWe O\nfound O\nit O\nwise O\nto O\ntake O\nsome O\ntime O\nbetween O\nthe O\ncommitment O\nto O\nstart O\nand O\nthe O\nactual O\nstart O\n, O\n\" O\nEOE B-ORG\nspokesman O\nLex B-PER\nvan I-PER\nDrooge I-PER\ntold O\nReuters B-ORG\n. O\n\nHe O\nsaid O\nno O\ndate O\nhad O\nbeen O\nfixed O\nyet O\nfor O\nthe O\nstart O\nof O\nprice O\nmaking O\nin O\nthe O\n10-year O\ncontract O\n, O\nbut O\nthe O\nEOE B-ORG\nhad O\nagreed O\nto O\nspeak O\nagain O\nto O\nthe O\nparticipants O\nin O\none O\nto O\ntwo O\nweeks O\n. O\n\nInvestors O\nin O\nDutch B-MISC\nbonds O\ncurrently O\nuse O\nGerman B-MISC\nbond O\nfutures O\nto O\nhedge O\ntheir O\nportfolios O\nbecause O\nthe O\nFTO B-ORG\ncontract O\nis O\nso O\nilliquid O\n. O\n\nA O\nlimited O\nattempt O\nto O\nreinvigorate O\nthe O\ncontract O\ntwo O\nyears O\nago O\nfailed O\n. O\n\n-- O\nAmsterdam B-LOC\nnewsroom O\n+31 O\n20 O\n504 O\n5000 O\n, O\nFax O\n+31 O\n20 O\n504 O\n5040 O\n\n-DOCSTART- O\n\nOSCE B-ORG\ndefends O\nrecord O\nover O\nChechnya B-LOC\npeace O\nmission O\n. O\n\nBONN B-LOC\n1996-08-30 O\n\nThe O\nhead O\nof O\nan O\ninternational O\nmediating O\nmission O\ndefended O\nits O\nrecord O\non O\nFriday O\nin O\nthe O\nface O\nof O\ncriticism O\nby O\npro-Moscow O\nleaders O\nin O\nbreakway O\nChechnya B-LOC\nand O\ninsisted O\nit O\nwas O\ndoing O\nits O\nbest O\nto O\nbring O\npeace O\nto O\nthe O\nregion O\n. O\n\nFlavio B-PER\nCotti I-PER\n, O\nthe O\nchairman O\nof O\nthe O\nOrganisation B-ORG\nfor I-ORG\nSecurity I-ORG\nand I-ORG\nCooperation I-ORG\nin I-ORG\nEurope I-ORG\n( O\nOSCE B-ORG\n) O\n, O\ntold O\nGerman B-MISC\nradio O\nthe O\nVienna-based B-MISC\nbody O\nviewed O\nthe O\nconflict O\nin O\nChechnya B-LOC\nas O\nan O\ninternal O\nRussian B-MISC\nproblem O\n. O\n\n\" O\nThe O\nOSCE B-ORG\nis O\ncompletely O\ninvolved O\n. O\n\nBut O\none O\nmust O\nnot O\nforget O\nthat O\nthe O\nOSCE B-ORG\nonly O\nhas O\nlimited O\npowers O\nthere O\n, O\n\" O\nsaid O\nCotti O\n, O\nwho O\nis O\nalso O\nthe O\nSwiss B-MISC\nforeign O\nminister O\n. O\n\" O\n\nOur O\nmission O\nin O\nChechnya B-LOC\nhas O\ndone O\nall O\nit O\ncan O\nwithin O\nthe O\ngiven O\nlimitations O\n. O\n\" O\n\nPro-Moscow B-MISC\nleaders O\nin O\nChechnya B-LOC\nhave O\ncriticised O\nTim B-PER\nGuldimann I-PER\n, O\nthe O\nSwiss B-MISC\ndiplomat O\nwho O\nheads O\nthe O\nOSCE B-ORG\nChechnya B-LOC\nmission O\n, O\nsaying O\nhe O\nwas O\nbiased O\ntoward O\nZelimkhan B-PER\nYandarbiyev I-PER\n, O\npresident O\nof O\nthe O\nself-declared O\nseparatist O\ngovernment O\n. O\n\nRussian B-MISC\npeacemaker O\nAlexander B-PER\nLebed I-PER\nand O\nChechen B-MISC\nseparatist O\nmilitary O\nleader O\nAslan B-PER\nMaskhadov I-PER\nstarted O\na O\nnew O\nround O\nof O\npeace O\ntalks O\non O\nFriday O\njust O\noutside O\nthe O\nrebel O\nregion O\n. O\n\nCotti B-PER\nsaid O\nChechnya B-LOC\nmust O\nremain O\npart O\nof O\nRussia B-LOC\n, O\nbut O\nthe O\nsolution O\nto O\nthe O\nconflict O\nwould O\nbe O\nto O\naccord O\nthe O\nregion O\nmaximum O\nautonomy O\nwithin O\nRussia B-LOC\n's O\nborders O\n. O\n\n\" O\nThere O\nis O\nno O\ndoubt O\nthat O\nChechnya B-LOC\n, O\naccording O\nto O\nOSCE B-ORG\nprinciples O\n, O\nbelongs O\nto O\na O\nstate O\ncalled O\nRussia B-LOC\n, O\n\" O\nhe O\nsaid O\n, O\npointing O\nout O\nthat O\nRussia B-LOC\nwas O\nan O\nOSCE B-ORG\nmember O\nand O\nit O\nwas O\nnot O\nthe O\norganisation O\n's O\npolicy O\nto O\nchallenge O\nmembers O\n' O\nsovereignty O\n. O\n\nHe O\nadded O\nthat O\nthe O\nOSCE B-ORG\nwas O\nthe O\nonly O\ninternational O\nbody O\nwhich O\nhas O\nbeen O\nallowed O\ninto O\nthe O\nChechnya B-LOC\nto O\nmonitor O\nthe O\nhuman O\nrights O\nsituation O\nthere O\n, O\nbut O\nthat O\nits O\nmeans O\nwere O\nrestricted O\nby O\nthe O\nfact O\nthat O\nthe O\nconflict O\nwas O\na O\n\" O\ninternal O\nissue O\n\" O\n. O\n\n\" O\nWe O\nhave O\na O\nsmall O\nconcept O\n, O\nthe O\ndetails O\nof O\nwhich O\nhave O\nyet O\nto O\nbe O\nworked O\nout O\n. O\n\nChechnya B-LOC\nmust O\nbe O\naccorded O\nthe O\nmaximum O\nautonomy O\npossible O\nwithin O\nthe O\nframework O\nof O\nRussian B-MISC\nintegrity O\n, O\n\" O\nsaid O\nCotti B-PER\n. O\n\n-DOCSTART- O\n\nDutch B-MISC\nsay O\nno O\nreason O\nto O\nreopen O\nEl B-ORG\nAl I-ORG\ncarqo O\nenquiry O\n. O\n\nTHE B-LOC\nHAGUE I-LOC\n1996-08-30 O\n\nThe O\nDutch B-MISC\ntransport O\nminister O\nAnnemarie B-PER\nJorritsma I-PER\ntold O\nthe O\ncountry O\n' O\nsecond O\nchamber O\nthat O\nthere O\nis O\nno O\nfurther O\nneed O\nto O\ninvestigate O\nthe O\n1992 O\ncrash O\nof O\nan O\nEl B-ORG\nAl I-ORG\nfreighter O\nwhich O\nleft O\n43 O\ndead O\nin O\nan O\nAmsterdam B-LOC\nsuburb O\n. O\n\nShe O\nsaid O\nthat O\na O\nrequest O\nfrom O\nher O\nministry O\nfor O\nthe O\naircraft O\n's O\nwaybill O\ndocumentation O\nand O\nfurther O\ninformation O\nabout O\nthe O\ncontents O\nof O\nits O\nhold O\nhad O\nbeen O\ncomplied O\nwith O\nby O\nEl B-ORG\nAl I-ORG\n's O\nhead O\noffice O\nin O\nTel B-LOC\nAviv I-LOC\n. O\n\nThe O\nDutch B-MISC\ntransport O\nministry O\nhad O\ncome O\nin O\nfor O\npressure O\nfrom O\na O\ncross-section O\nof O\nDutch B-MISC\nmembers O\nof O\nparliaments O\nin O\nMay O\nthis O\nyear O\n, O\nsome O\nof O\nwhom O\nbelieved O\nthe O\naircraft O\nhad O\nbeen O\ncarrying O\nunlisted O\n, O\ndangerous O\ngoods O\n. O\n\nOthers O\nsaid O\nthey O\nthought O\nthe O\naircraft O\nwas O\nloaded O\nwith O\ntoo O\nmuch O\nairfreight O\n. O\n\nJorritsma B-PER\nsaid O\nthe O\nlatest O\nevidence O\nfrom O\nEl B-ORG\nAl I-ORG\nin O\nno O\nway O\nsupported O\nthe O\nallegations O\n, O\nand O\nadded O\nthere O\nis O\nno O\njustification O\nfor O\na O\nfurther O\ninvestigation O\ninto O\nthe O\nincident O\n. O\n\n-- O\nAir B-ORG\nCargo I-ORG\nNewsroom I-ORG\nTel+44 O\n171 O\n542 O\n8982 O\nFax O\n+44 O\n171 O\n542 O\n5017 O\n\n-DOCSTART- O\n\nArmenians B-MISC\n, O\nAzeris B-MISC\nhold O\npeace O\ntalks O\nin O\nGermany B-LOC\n. O\n\nBONN B-LOC\n1996-08-30 O\n\nRepresentatives O\nfrom O\nArmenia B-LOC\nand O\nAzerbaijan B-LOC\nheld O\ntalks O\nearlier O\nthis O\nweek O\nin O\nGermany B-LOC\non O\nbringing O\na O\nlasting O\npeace O\nto O\nthe O\ndisputed O\nNagorno-Karabakh B-LOC\nregion O\n, O\na O\ndiplomatic O\nsource O\nclose O\nto O\nthe O\ntalks O\nsaid O\non O\nFriday O\n. O\n\nThe O\nsource O\n, O\nwho O\nspoke O\non O\ncondition O\nof O\nanonymity O\n, O\nsaid O\nAzerbaijani B-PER\npresidential O\nadviser O\nVafa B-PER\nGulizade I-PER\nand O\nhis O\nArmenian B-MISC\ncounterpart O\nZhirayr B-PER\nLiparityan I-PER\nmet O\nto O\ndiscuss O\nthe O\ndisputed O\nenclave O\non O\nWednesday O\nand O\nhad O\nnow O\nflown O\nhome O\n. O\n\nAn O\nuneasy O\nceasefire O\nhas O\nprevailed O\nin O\nNagorno-Karabakh B-LOC\n, O\nwhich O\nrepresents O\naround O\n20 O\npercent O\nof O\nAzeri B-MISC\nterritory O\n, O\nsince O\nMay O\n1994 O\nafter O\nethnic O\nArmenians B-MISC\ndrove O\nAzeris B-MISC\nout O\nof O\nthe O\nregion O\n. O\n\nThe O\nconflict O\n, O\nwhich O\nbegan O\nin O\n1988 O\n, O\nclaimed O\nover O\n10,000 O\nlives O\n. O\n\n\" O\nThe O\nmain O\nsubject O\n( O\nof O\nthe O\ntalks O\n) O\nwas O\nthe O\nsearch O\nfor O\na O\npeaceful O\nsolution O\nfor O\nNagorno-Karabakh B-LOC\n, O\n\" O\nthe O\nsource O\nsaid O\n. O\n\nHe O\ndeclined O\nto O\nreveal O\nany O\nmore O\ndetails O\nabout O\nthe O\ncontent O\nof O\nthe O\ntalks O\nor O\ntheir O\nexact O\nlocation O\nin O\nGermany B-LOC\n. O\n\nAzerbaijan B-LOC\nhas O\nsaid O\nit O\nis O\nprepared O\nto O\ngrant O\nautonomy O\nto O\nNagorno-Karabakh B-LOC\nif O\nArmenian O\nforces O\npull O\nout O\n, O\nbut O\nwill O\nnot O\naccept O\nArmenia B-LOC\n's O\ndemands O\nfor O\nthe O\nindependence O\nof O\nthe O\nenclave O\n. O\n\nRussia B-LOC\n's O\nInterfax B-ORG\nnews O\nagency O\nreported O\non O\nTuesday O\nthe O\nofficials O\nhad O\ndeparted O\nfor O\nnegotiations O\nin O\nGermany B-LOC\n, O\nadding O\nthat O\nface-to-face O\ntalks O\nbetween O\nthe O\ntwo O\nsides O\nfirst O\ntook O\nplace O\nlast O\nDecember O\nin O\nAmsterdam B-LOC\n. O\n\nInterfax B-ORG\nsaid O\nthe O\ndiscussions O\nwere O\nbeing O\nheld O\nin O\nparallel O\nwith O\npeace O\ntalks O\nmediated O\nby O\nthe O\nOrganisation B-ORG\nfor I-ORG\nSecurity I-ORG\nand I-ORG\nCooperation I-ORG\nin I-ORG\nEurope I-ORG\n( O\nOSCE B-ORG\n) O\nand O\nthe O\nbroad-based O\nMinsk B-ORG\nGroup I-ORG\nof O\ncountries O\nled O\nby O\nRussia B-LOC\nand O\nFinland B-LOC\n. O\n\n-DOCSTART- O\n\nSombre O\nmood O\non O\nArctic B-MISC\nisland O\nafter O\nplane O\ncrash O\n. O\n\nRolf B-PER\nSoderlind I-PER\n\nLONGYEAR B-LOC\n, O\nNorway B-LOC\n1996-08-30 O\n\nThe O\nwindblown O\n, O\nchilly O\nstreets O\nof O\nthis O\ntiny O\nArctic B-MISC\ntown O\nare O\nall O\nbut O\ndeserted O\nand O\nflags O\nare O\nflying O\nat O\nhalf-mast O\nbeneath O\na O\nbrooding O\n, O\nclouded O\nsky O\n. O\n\nLongyear B-LOC\nis O\na O\ntown O\nin O\nmourning O\n, O\na O\nclose-knit O\ncommunity O\nthat O\nhas O\nbeen O\nshattered O\n. O\n\nDisaster O\nstruck O\non O\nThursday O\nwhen O\na O\nRussian B-MISC\nairliner O\nbringing O\ncoal O\nminers O\nto O\nwork O\ncrashed O\nas O\nit O\ncame O\nin O\nto O\nland O\nat O\nthe O\nairport O\n, O\nkilling O\nall O\n141 O\npeople O\non O\nboard O\n. O\n\n\" O\nIt O\n's O\na O\nsight O\nI O\nwill O\nnever O\nforget O\n. O\n\nI O\nwill O\nremember O\nit O\nfor O\nthe O\nrest O\nof O\nmy O\nlife O\n, O\n\" O\nsaid O\nStig B-PER\nOnarheim I-PER\n. O\n\nHe O\nwas O\none O\nof O\na O\nhandful O\nof O\nrescuers O\nwho O\nraced O\nto O\nthe O\nscene O\nof O\nthe O\ncrash O\nin O\na O\nhelicopter O\non O\nThursday O\n, O\nhoping O\nin O\nvain O\nto O\nfind O\nsurvivors O\n. O\n\nThe O\nplane O\nsmashed O\ninto O\na O\nsnow-capped O\nmountain O\non O\nthe O\nArctic B-MISC\nisland O\nof O\nSpitzbergen B-LOC\non O\nThursday O\n, O\njust O\neast O\nof O\nLongyear B-LOC\n. O\n\n\" O\nImagine O\na O\nbig O\nplane O\nwith O\na O\nlot O\nof O\nluggage O\nand O\npeople O\non O\nboard O\n. O\n\nThink O\nof O\nall O\nthat O\nmixed O\ntogether O\n, O\nwith O\ntwisted O\n, O\nwrecked O\nparts O\non O\nthe O\nslope O\n, O\n\" O\nOnarheim B-LOC\n, O\n29 O\n, O\ntold O\nReuters B-ORG\n. O\n\nPolice O\nand O\nlocal O\nofficials O\nhave O\nsealed O\noff O\nthe O\ncrash O\nsite O\n, O\nprotecting O\nit O\nfrom O\nintrusive O\nreporters O\nand O\nfrom O\nthe O\npolar O\nbears O\nthat O\nroam O\nfreely O\nacross O\nthe O\nicy O\nexpanses O\n. O\n\nThe O\ndead O\nwere O\nall O\nRussians B-MISC\nand O\nUkrainians B-MISC\n, O\ncoming O\nto O\nwork O\nin O\nthe O\nmining O\ntowns O\nof O\nBarentsburg B-LOC\nand O\nPyramiden B-LOC\n. O\n\nLongyear B-LOC\nis O\na O\nNorwegian B-MISC\nsettlement O\nof O\njust O\nover O\n1,000 O\npeople O\n, O\nbut O\nit O\nalso O\nfeels O\nthe O\nloss O\nkeenly O\n. O\n\n\" O\nI O\nhave O\ntrouble O\nfinding O\nthe O\nwords O\nto O\nexpress O\nmy O\ngrief O\n. O\n\nIt O\n's O\na O\ntragedy O\nfor O\neveryone O\n. O\n\nWe O\nknow O\nmany O\nof O\nthe O\npeople O\nwho O\nlive O\nin O\nBarentsburg B-LOC\n, O\nsome O\nof O\nthem O\ncould O\nhave O\nbeen O\non O\nthe O\nplane O\n, O\n\" O\nsaid O\nJohan B-PER\nSletten I-PER\n, O\n52 O\n. O\n\nSletten B-PER\n, O\na O\ncaretaker O\nwho O\nhas O\nlived O\non O\nthe O\nisland O\nfor O\n30 O\nyears O\n, O\nsaid O\nthe O\nNorwegian B-MISC\nand O\nRussian B-MISC\ncommunities O\nvisit O\nfrequently O\n, O\ncompeting O\nat O\nsoccer O\nin O\nthe O\nsummer O\nand O\nwith O\nsnow-scooter O\nraces O\nin O\nthe O\nwinter O\n. O\n\nTeenage O\nshop O\nassistant O\nHeidi B-PER\nGroenstein I-PER\nwas O\nblunter O\n. O\n\n\" O\nI O\n'm O\nglad O\nit O\nwas O\nnot O\na O\nNorwegian B-MISC\nplane O\n, O\n\" O\nshe O\nsaid O\n. O\n\" O\n\nJust O\nthink O\nof O\nit O\n-- O\na O\nmining O\nvillage O\nwhere O\nso O\nmany O\nworkers O\ndie O\n. O\n\nThey O\nmust O\nbe O\nhaving O\na O\ntough O\ntime O\nof O\nit O\nnow O\n. O\n\" O\n\nBarentsburg B-LOC\n, O\njust O\na O\nfew O\nhours O\nride O\nby O\nsnow-scooter O\nor O\n15 O\nminutes O\nby O\nhelicopter O\nfrom O\nLongyear B-LOC\n, O\nhas O\nasked O\nto O\nbe O\nleft O\nalone O\nwith O\nits O\ngrief O\nand O\ntold O\nreporters O\nto O\nstay O\naway O\n. O\n\nAround O\n100 O\nRussian B-MISC\nand O\nUkrainian B-MISC\nminers O\nwere O\nwaiting O\nin O\nLongyear B-LOC\nto O\nfly O\nhome O\non O\nthe O\nplane O\nthat O\ncrashed O\n. O\n\nThey O\nwere O\ngiven O\nshelter O\nin O\nthe O\ntown O\n's O\nchurch O\novernight O\nand O\nate O\na O\nsombre O\nbreakfast O\nbefore O\ngetting O\non O\na O\nbus O\nfor O\nthe O\nairport O\n. O\n\nAnother O\nplane O\nhad O\nbeen O\nsent O\nfrom O\nMoscow B-LOC\nto O\npick O\nthem O\nup O\n. O\n\nAt O\nthis O\ntime O\nof O\nyear O\n, O\nthe O\nonly O\ncolour O\nin O\nLongyear B-LOC\ncomes O\nfrom O\nthe O\nbrightly-painted O\nwooden O\nhouses O\n. O\n\nEverything O\nelse O\nis O\nmuddy O\n, O\nthe O\nwaters O\nof O\nthe O\nfjord O\nleaden O\n. O\n\nWinter O\nis O\nin O\nthe O\nair O\n. O\n\nBarentsburg B-LOC\nis O\nan O\neven O\ngrimmer O\nplace O\n, O\na O\nrun-down O\ntestament O\nto O\nthe O\nhardships O\nof O\nthe O\nnew O\nRussia B-LOC\n. O\n\nSpitzbergen B-LOC\nlies O\nsome O\n500 O\nmiles O\n( O\n800 O\nkm O\n) O\noff O\nthe O\nnorthern O\ntip O\nof O\nNorway B-LOC\nand O\nendures O\none O\nof O\nthe O\nmost O\nextreme O\nclimates O\non O\nthe O\nplanet O\n. O\n\nInhabited O\nby O\nfewer O\nthan O\n3,000 O\npeople O\nin O\ntotal O\n, O\nit O\nsees O\nthe O\nsun O\nfor O\n24 O\nhours O\na O\nday O\nduring O\nsummer O\nand O\nis O\nplunged O\ninto O\nround-the-clock O\ndarkness O\nin O\nthe O\nwinter O\nmonths O\n. O\n\nThe O\nterrain O\nis O\nmountainous O\n, O\nthe O\nonly O\nroads O\nare O\ndirt O\ntracks O\n. O\n\nNorway B-LOC\nrules O\nthe O\nisland O\ngroup O\nunder O\nthe O\nterms O\nof O\na O\n1920s O\ninternational O\ntreaty O\nwhich O\ngave O\nmany O\nother O\nnations O\nthe O\nright O\nto O\nestablish O\nsetttlements O\nand O\nexploit O\nthe O\ncoal O\nthat O\nis O\nstill O\nmined O\nthere O\n. O\n\nOnly O\nRussia B-LOC\nhas O\nchosen O\nto O\ndo O\nso O\n. O\n\n-DOCSTART- O\n\nEricsson B-ORG\nsays O\nwins O\n1.2 O\nbln O\nSKR O\nChina B-LOC\norder O\n. O\n\nSTOCKHOLM B-LOC\n1996-08-30 O\n\nSwedish B-MISC\ntelecoms O\ngroup O\nLM B-ORG\nEricsson I-ORG\nAB I-ORG\nsaid O\non O\nFriday O\nit O\nwon O\nan O\norder O\nworth O\n1.2 O\nbillion O\ncrowns O\nfor O\na O\nfixed O\npublic O\ntelecoms O\nnetwork O\nin O\nthe O\nGuangdong B-LOC\nprovince O\nof O\nChina B-LOC\n. O\n\nEricsson B-ORG\nsaid O\nin O\na O\nstatement O\nthe O\norder O\nwas O\nfrom O\nthe O\nGuangdong B-ORG\nPost I-ORG\nand I-ORG\nTelecommunications I-ORG\nAdministration I-ORG\n( O\nGPTA B-ORG\n) O\n. O\n\nThe O\norder O\nincluded O\nAXE B-MISC\nswitching O\nequipment O\n, O\nISDN O\nequipment O\n, O\nIntelligent B-MISC\nNetwork I-MISC\n( O\nIN B-MISC\n) O\nproducts O\n, O\nbroad-band O\nmulti-media O\ncommunication O\nnetwork O\nproducts O\n, O\nservices O\nand O\ntraining O\n, O\nEricsson B-ORG\nspokesman O\nPer B-PER\nZetterquist I-PER\ntold O\nReuters B-ORG\n. O\n\nDeliveries O\nare O\ndue O\nto O\nbe O\ncompleted O\nby O\n1999 O\n, O\nthe O\ncompany O\nsaid O\n. O\n\n-- O\nStockholm B-LOC\nnewsroom O\n+46-8-700 O\n1017 O\n\n-DOCSTART- O\n\nHK B-LOC\nhas O\ninfrastructure O\nin O\nplace O\nfor O\npost-97 O\n- O\nTsang B-PER\n. O\n\nAUCKLAND B-LOC\n1996-08-30 O\n\nHong B-LOC\nKong I-LOC\nFinancial O\nSecretary O\nDonald B-PER\nTsang I-PER\nsaid O\non O\nFriday O\nthat O\nthe O\nterritory O\nhad O\nthe O\n\" O\ninfrastructural O\nhardware O\n\" O\nto O\nmake O\na O\nsuccess O\nof O\nits O\nfuture O\nunder O\nChinese B-MISC\nsovereignty O\nfrom O\nmid-1997 O\n. O\n\n\" O\nWe O\nhave O\nthe O\nlargest O\nand O\nmost O\nefficient O\nport O\non O\nthe O\nSouth B-LOC\nChina I-LOC\ncoast O\n; O\nwe O\nhave O\nthe O\nbest O\ntransport O\nand O\ntelecommunications O\ninfrastructure O\nin O\nthe O\nworld O\n; O\nand O\nwe O\nare O\ninvesting O\nin O\nthis O\nhardware O\non O\nan O\nenormous O\nscale O\n, O\n\" O\nTsang B-PER\nsaid O\nin O\na O\nspeech O\nto O\nAuckland B-LOC\nduring O\na O\nvisit O\nto O\nNew B-LOC\nZealand I-LOC\n. O\n\nHong B-LOC\nKong I-LOC\nalso O\nhad O\nthe O\nnecessary O\n\" O\nconstitutional O\ninfrastructure O\n\" O\nin O\nplace O\n, O\nwith O\nthe O\npromise O\nof O\nautonomy O\nin O\nrunning O\nits O\naffairs O\nafter O\nthe O\nhandover O\nfrom O\nBritain B-LOC\nto O\nChina B-LOC\n. O\n\n\" O\nWhat O\nthis O\nmeans O\nin O\npractice O\nis O\nthat O\nHong B-LOC\nKong I-LOC\nwill O\ngo O\non O\nraising O\nits O\nown O\ntaxes O\n, O\nissuing O\nits O\nown O\ncurrency O\n, O\nsetting O\nits O\nown O\nexpenditure O\npriorities O\nand O\nmanaging O\nits O\nown O\nenormous O\nfinancial O\nreserves O\n, O\n\" O\nTsang B-PER\nsaid O\n. O\n\nHe O\nacknowledged O\nthat O\nmany O\nHong B-LOC\nKong I-LOC\npeople O\nhad O\ndecided O\nto O\nseek O\ntheir O\nfuture O\nelsewhere O\nand O\nothers O\nwere O\nsure O\nto O\nfollow O\nin O\nthe O\nnext O\nnine O\nmonths O\n. O\n\" O\n\nBut O\nfor O\nthe O\ngreat O\nmajority O\nof O\nus O\n, O\nHong B-LOC\nKong I-LOC\nis O\nour O\nhome O\nand O\nHong B-LOC\nKong I-LOC\n's O\nfuture O\nis O\nour O\nfuture O\n. O\n\" O\n\n-- O\nWellington B-LOC\nnewsroom O\n64 O\n4 O\n473-4746 O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nIndonesian B-MISC\nnewspapers O\n- O\nAugust O\n30 O\n. O\n\nFollowing O\nis O\na O\nsummary O\nof O\nmajor O\nIndonesian B-MISC\npolitical O\nand O\nbusiness O\nstories O\nin O\nleading O\nnewspapers O\n, O\nprepared O\nby O\nReuters B-ORG\nin O\nJakarta B-LOC\n. O\n\nReuters B-ORG\nhas O\nnot O\nchecked O\nthe O\nstories O\nand O\ndoes O\nnot O\nguarantee O\ntheir O\naccuracy O\n. O\n\nTelephone O\n: O\n( O\n6221 O\n) O\n384-6364 O\n. O\n\nFax O\n: O\n( O\n6221 O\n) O\n344-8404 O\n. O\n\n- O\n- O\n- O\n- O\n\nKOMPAS B-ORG\n\nIndonesian B-MISC\nPresident O\nSuharto B-PER\nhas O\nasked O\nbusinessmen O\nto O\nshare O\ntheir O\nexperiences O\nwith O\neach O\nother O\nin O\nan O\neffort O\nto O\nboost O\nthe O\ncountry O\n's O\nexports O\n. O\n\n- O\n- O\n- O\n- O\n\nJAKARTA B-ORG\nPOST I-ORG\n\nSpeaker O\nof O\nthe O\nHouse B-ORG\nof I-ORG\nRepresentatives I-ORG\nWahono B-PER\nhas O\ncalled O\non O\nthose O\nserving O\nin O\nhigh O\nstate O\ninstitutions O\nto O\ndirect O\ntheir O\nefforts O\nin O\nthe O\ncoming O\nyears O\ntowards O\ndismantling O\nall O\nbarriers O\nto O\nsocial O\njustice O\n. O\n\nAn O\nagreement O\nto O\nbring O\npeace O\nto O\nthe O\nsouthern O\nPhilippines B-LOC\nis O\nset O\nto O\nbe O\ninitialed O\non O\nFriday O\nafter O\ndelegates O\nfrom O\nthe O\nPhilippine B-LOC\ngovernment O\nand O\nthe O\nMoro B-ORG\nNational I-ORG\nLiberation I-ORG\nFront I-ORG\n( O\nMNLF B-ORG\n) O\nconcluded O\nnegotiations O\non O\nthe O\ntreaty O\nwhich O\nis O\nset O\nto O\nend O\nalmost O\n25 O\nyears O\nof O\nconflict O\nin O\nthe O\nregion O\n. O\n\n- O\n- O\n- O\n- O\n\nMEDIA B-ORG\nINDONESIA I-ORG\n\nAround O\n2,000 O\nof O\nIndonesia B-LOC\n's O\ncontroversial O\nTimor O\nnational O\ncar O\nmade O\nby O\nKia B-ORG\nMotor I-ORG\nCorp I-ORG\nof O\nSouth B-LOC\nKorea I-LOC\narrived O\nat O\nJakarta B-LOC\n's O\nTanjung B-LOC\nPriok I-LOC\nport O\non O\nThursday O\n. O\n\nThe O\ncars O\nwill O\nbe O\njointly O\nmarketed O\nby O\nKia B-ORG\nand O\nPT B-ORG\nTimor I-ORG\nPutra I-ORG\nNasional I-ORG\n, O\ncontrolled O\nby O\na O\nson O\nof O\nPresident O\nSuharto B-PER\n, O\nwhich O\nplans O\nnext O\nyear O\nto O\nstart O\nassembling O\nthe O\nvehicles O\nin O\nIndonesia B-LOC\n. O\n\n- O\n- O\n- O\n- O\n\nREPUBLIKA B-ORG\n\nThe O\nCentral B-ORG\nJakarta I-ORG\nDistrict I-ORG\nCourt I-ORG\nhas O\nstarted O\nto O\nhear O\nthe O\nsuit O\nfiled O\nby O\nousted O\nIndonesian B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nPDI B-ORG\n) O\nleader O\nMegawati B-PER\nSukarnoputri I-PER\nagainst O\nthe O\ngovernment O\nand O\nparty O\nrivals O\nafter O\nthe O\nparties O\nfailed O\nto O\nreach O\nan O\nout-of-court O\nsettlement O\n. O\n\nMegawati B-PER\nhas O\nsued O\nthe O\ndefendants O\nover O\na O\ngovernment-backed O\nrebel O\ncongress O\nwhich O\nousted O\nher O\nlast O\nJune O\n. O\n\n-DOCSTART- O\n\nJeans B-ORG\nMate I-ORG\nCorp I-ORG\n- O\n6mth O\nparent O\nforecast O\n. O\n\nTOKYO B-LOC\n1996-08-30 O\n\nSix O\nmonths O\nto O\nAugust O\n20 O\n, O\n1996 O\n\n( O\nin O\nbillions O\nof O\nyen O\nunless O\nspecified O\n) O\n\nLATEST O\nPREVIOUS O\nACTUAL O\n\n( O\nParent O\n) O\nFORECAST O\nFORECAST O\nYEAR-AGO O\n\nSales O\n9.06 O\n9.31 O\n8.42 O\n\nCurrent O\n818 O\nmillion O\n979 O\nmillion O\n882 O\nmillion O\n\nNet O\n415 O\nmillion O\n490 O\nmillion O\n412 O\nmillion O\n\nNOTE O\n- O\nJeans B-ORG\nMate I-ORG\nCorp I-ORG\nis O\nthe O\nfull O\ncompany O\nname O\n. O\n\n-DOCSTART- O\n\nApic B-ORG\nYamada I-ORG\n- O\n6mth O\nparent O\nforecast O\n. O\n\nTOKYO B-LOC\n1996-08-30 O\n\nSix O\nmonths O\nto O\nSeptember O\n30 O\n, O\n1996 O\n\n( O\nin O\nbillions O\nof O\nyen O\nunless O\nspecified O\n) O\n\nLATEST O\nPREVIOUS O\nACTUAL O\n\n( O\nParent O\n) O\nFORECAST O\nFORECAST O\nYEAR-AGO O\n\nSales O\n12.50 O\n13.00 O\n11.27 O\n\nCurrent O\n1.30 O\n1.35 O\n1.09 O\n\nNet O\n650 O\nmillion O\n680 O\nmillion O\n600 O\nmillion O\n\nNOTE O\n- O\nApic B-ORG\nYamada I-ORG\nCorp I-ORG\nis O\na O\nleading O\nmanufacturer O\nof O\nsemiconductor O\nleadframes O\n. O\n\n-DOCSTART- O\n\nBootleg O\nbrew O\nkills O\n35 O\nin O\nChina B-LOC\n, O\npolice O\nnab O\nsuspects O\n. O\n\nBEIJING B-LOC\n1996-08-30 O\n\nPolice O\nin O\nsouthwest O\nChina B-LOC\nhave O\narrested O\n30 O\npeople O\nsuspected O\nof O\nmaking O\nand O\nselling O\nhomemade O\nalcohol O\nthat O\nkilled O\n35 O\npeople O\nand O\npoisoned O\n157 O\n, O\nthe O\nXinhua B-ORG\nnews O\nagency O\nsaid O\non O\nFriday O\n. O\n\nA O\ngroup O\nof O\nfarmers O\nin O\nHuize B-LOC\ncounty O\nin O\nthe O\nsouthwestern O\nprovince O\nof O\nYunnan B-LOC\nwere O\narrested O\nfor O\nblending O\nalcohol O\nwith O\nmethanol O\nand O\nselling O\nthe O\ntoxic O\nliquor O\nto O\nlocal O\nresidents O\n, O\nthe O\nagency O\nsaid O\n. O\n\nBetween O\nlate O\nJune O\nand O\nJuly O\n, O\na O\ntotal O\nof O\n192 O\npeople O\nwere O\npoisoned O\nby O\nthe O\ntoxic O\nliquor O\n, O\nand O\n35 O\nof O\nthem O\ndied O\nand O\nsix O\nwere O\nleft O\nseverely O\nhandicapped O\n, O\nit O\nsaid O\n. O\n\nLocal O\nauthorities O\nlaunched O\nan O\ninvestigation O\nafter O\nthey O\nreceived O\nreports O\nof O\nseveral O\nsimilar O\ndeaths O\nin O\nthe O\narea O\n, O\nit O\nsaid O\n. O\n\nPost-mortem O\nexaminations O\nshowed O\nthey O\nwere O\nall O\ncaused O\nby O\nmethanol O\npoisoning O\n. O\n\nPolice O\nhad O\nconfiscated O\nthe O\nremainder O\nof O\nthe O\npoisonous O\nliquor O\n, O\nXinhua B-ORG\nsaid O\n. O\n\nIt O\ngave O\nno O\nfurther O\ndetails O\n. O\n\n-DOCSTART- O\n\nSingapore B-LOC\nhangs O\nThai B-MISC\ndrug O\ntrafficker O\n. O\n\nSINGAPORE B-LOC\n1996-08-30 O\n\nSingapore B-LOC\nhanged O\na O\nThai B-MISC\nfarmer O\nat O\nChangi B-LOC\nPrison I-LOC\non O\nFriday O\nfor O\ndrug O\ntrafficking O\n, O\nthe O\nCentral B-ORG\nNarcotics I-ORG\nBureau I-ORG\n( O\nCNB B-ORG\n) O\nsaid O\n. O\n\nJeerasak B-PER\nDensakul I-PER\n, O\n24 O\n, O\nwas O\narrested O\nin O\n1995 O\nwhen O\nhe O\nwas O\nfound O\nwith O\n11 O\nslabs O\nof O\ncannabis O\nweighing O\n2.2 O\nkg O\n( O\n4.8 O\npounds O\n) O\n, O\nthe O\nCNB B-ORG\nsaid O\n. O\n\nSingapore B-LOC\nhas O\na O\nmandatory O\ndeath O\nsentence O\nfor O\nanyone O\nover O\n18 O\nyears O\nof O\nage O\nfound O\nguilty O\nof O\ntrafficking O\nin O\nmore O\nthan O\n15 O\ngrams O\n( O\nhalf O\nan O\nounce O\n) O\nof O\nheroin O\n, O\n30 O\ngrams O\n( O\nan O\nounce O\n) O\nof O\nmorphine O\nor O\n500 O\ngrams O\n( O\n18 O\noz O\n) O\nof O\ncannabis O\nor O\nmarijuana O\n. O\n\nOf O\nthe O\nnearly O\n270 O\npeople O\nhanged O\nfor O\nvarious O\ncrimes O\nin O\nSingapore B-LOC\nsince O\n1975 O\n, O\nalmost O\nhalf O\nhave O\nbeen O\nfor O\ndrug-related O\ncharges O\n. O\n\n-DOCSTART- O\n\nArafat B-PER\ngoes O\nto O\nNablus B-LOC\nahead O\nof O\ncabinet O\nmeeting O\n. O\n\nNABLUS B-LOC\n, O\nWest B-LOC\nBank I-LOC\n1996-08-30 O\n\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\narrived O\nin O\nthe O\nWest B-LOC\nBank I-LOC\nself-rule O\nenclave O\nof O\nNablus B-LOC\nfrom O\nRamallah B-LOC\non O\nFriday O\n, O\nwitnesses O\nsaid O\n. O\n\nHis O\naides O\nsaid O\nArafat B-PER\nwould O\nhold O\nthe O\nweekly O\nmeeting O\nof O\nthe O\nPalestinian B-ORG\nself-rule I-ORG\nAuthority I-ORG\n's O\ncabinet O\nin O\nNablus B-LOC\non O\nSaturday O\n. O\n\nIn O\nJerusalem B-LOC\n, O\nIsraeli B-MISC\nsecurity O\nforces O\nwere O\nbracing O\nfor O\nthousands O\nof O\nPalestinians B-MISC\nexpected O\nto O\nanswer O\nArafat B-PER\n's O\ncall O\nearlier O\nthis O\nweek O\nto O\ncome O\nto O\nthe O\ncity O\nholy O\nto O\nMoslems B-MISC\n, O\nArabs B-MISC\nand O\nJews B-MISC\nto O\npray O\nin O\nprotest O\nagainst O\nIsrael B-LOC\n's O\nsettlement O\npolicy O\nin O\nthe O\nWest B-LOC\nBank I-LOC\nand O\ndelay O\nin O\npeace O\nnegotiations O\n. O\n\nPalestinians B-MISC\nwant O\nArab B-LOC\nEast I-LOC\nJerusalem I-LOC\nas O\nthe O\ncapital O\nof O\na O\nfuture O\nindependent O\nstate O\n. O\n\nIsrael B-LOC\n, O\nwhich O\ncaptured O\nand O\nannexed O\nEast B-LOC\nJerusalem I-LOC\nin O\n1967 O\n, O\nsays O\nit O\nwill O\nnever O\ncede O\nany O\npart O\nof O\nthe O\ncity O\n. O\n\nArafat B-PER\n, O\nwho O\nmade O\nan O\ninterim O\npeace O\ndeal O\nwith O\nIsrael B-LOC\nin O\n1993 O\nthat O\nset O\nup O\nself-rule O\n, O\nsays O\nhe O\nwill O\nonly O\nvisit O\nJerusalem B-LOC\nonce O\nIsraeli B-MISC\noccupation O\nhas O\nended O\n. O\n\n-DOCSTART- O\n\nU.N. B-ORG\nCouncil I-ORG\nconcerned O\nabout O\nIsraeli B-MISC\nbulldozers O\n. O\n\nUNITED B-ORG\nNATIONS I-ORG\n1996-08-29 O\n\nSecurity B-ORG\nCouncil I-ORG\nmembers O\nexpressed O\nconcern O\non O\nThursday O\nthat O\nIsrael B-LOC\n's O\nbulldozing O\nof O\na O\nPalestinian B-MISC\nday-care O\ncentre O\nfor O\nthe O\ndisabled O\nmight O\nfurther O\ninjure O\nthe O\nMiddle B-LOC\nEast I-LOC\npeace O\nprocess O\n. O\n\nResponding O\nto O\na O\nletter O\nfrom O\nthe O\nthe O\nPalestinian B-MISC\nU.N. B-ORG\nobserver O\nmission O\n, O\nSecurity B-ORG\nCouncil I-ORG\nPresident O\nTono B-PER\nEitel I-PER\nof O\nGermany B-LOC\nsaid O\nthat O\nmembers O\nasked O\nhim O\nto O\nconvey O\ntheir O\nviews O\nto O\nIsrael B-LOC\n's O\ncharge O\nd'affaires O\n, O\nDavid B-PER\nPeleg I-PER\n. O\n\n\" O\nThe O\nmembers O\nexpressed O\ntheir O\nconcern O\nabout O\nthe O\nmaintenance O\nof O\nthe O\npeace O\nprocess O\nand O\nthey O\nurged O\nthat O\nno O\naction O\nbe O\ntaken O\nthat O\nwould O\nhave O\na O\nnegative O\nimpact O\non O\nthe O\nnegotiations O\n, O\n\" O\nEitel B-PER\nsaid O\nafter O\nan O\ninformal O\ncouncil O\nsession O\n. O\n\n\" O\nThey O\nasked O\nme O\nto O\ncall O\nin O\nthe O\nIsraeli B-MISC\ncharge O\nd'affaires O\nand O\ndiscuss O\nthe O\nmatter O\nwith O\nhim O\n, O\n\" O\nhe O\nadded O\n. O\n\nThe O\nPalestinian B-MISC\nletter O\nfrom O\nMarwan B-PER\nJilani I-PER\nsaid O\nthe O\ndestruction O\nof O\nthe O\nJerusalem B-LOC\ncentre O\nwas O\nan O\neffort O\nby O\nIsrael B-LOC\nto O\n\" O\nalter O\nthe O\ncharacter O\n, O\ndemographic O\ncomposition O\nand O\nstatus O\nof O\nthe O\nHoly B-LOC\nCity I-LOC\nof I-LOC\nJerusalem I-LOC\n\" O\nand O\nviolated O\nagreements O\nbetween O\nIsrael B-LOC\nand O\nthe O\nPalestinian B-ORG\nLiberation I-ORG\nOrganisation I-ORG\n. O\n\n\" O\nThis O\nmost O\nrecent O\nmeasure O\nrepresents O\na O\nrevival O\nof O\nold O\n, O\nmalicious O\nplans O\nto O\nconfiscate O\nthe O\nland O\nand O\nbuild O\nunits O\nfor O\nIsraeli B-MISC\nsettlers O\nwithin O\nthe O\nwalls O\nof O\nthe O\nOld B-LOC\nCity I-LOC\n. O\n\" O\n\n\" O\nWe O\nexpect O\nthe O\ninternational O\ncommunity O\nto O\ntake O\na O\nclear O\nand O\nfirm O\nposition O\n, O\nbased O\non O\ninternational O\nlaw O\nand O\nin O\naccordance O\nwith O\nU.N. B-ORG\nresolutions O\n, O\nagainst O\nall O\nsuch O\nIsraeli B-MISC\nviolations O\nand O\nillegal O\npractices O\n, O\n\" O\nhe O\nsaid O\n. O\n\nOn O\nTuesday O\n, O\nIsraeli B-MISC\ncrews O\nhoisted O\na O\nbulldozer O\nover O\nthe O\nwalls O\nof O\nJerusalem B-LOC\n's O\nold O\ncity O\nand O\ndemolished O\nthe O\ncentre O\n, O\nsaying O\nit O\nwas O\nbeing O\nrestored O\nwithout O\na O\nbuilding O\npermit O\n. O\n\nCanada B-LOC\nhad O\nrecently O\ndonated O\n$ O\n30 O\nmillion O\nto O\nthe O\ncentre O\n, O\ncalled O\nthe O\nBurj B-LOC\nal-Laqlaq I-LOC\nSociety I-LOC\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nREAL B-ORG\nSCRAPE O\n1-1 O\nDRAW O\nIN O\nSCRAPPY O\nOPENING O\nMATCH O\n. O\n\nLA B-LOC\nCORUNA I-LOC\n, O\nSpain B-LOC\n1996-08-31 O\n\nA O\nlate O\ngoal O\nby O\nnewly-signed O\ndefender O\nRoberto B-PER\nCarlos I-PER\nsaved O\nthe O\nblushes O\nof O\nReal B-ORG\nMadrid I-ORG\ncoach O\nFabio B-PER\nCapello I-PER\nand O\nhis O\nmulti-billion O\npeseta O\nline-up O\nin O\nthe O\nopening O\ngame O\nof O\nthe O\nSpanish B-MISC\nchampionship O\non O\nSaturday O\n. O\n\nThe O\nBrazilian B-MISC\n's O\n79th-minute O\neffort O\nwas O\nenough O\nto O\nearn O\nReal B-ORG\na O\npoint O\nfrom O\na O\nscrappy O\n1-1 O\ndraw O\nat O\nfellow O\ntitle O\ncontenders O\nDeportivo B-ORG\nCoruna I-ORG\n. O\n\nDeportivo B-ORG\nstarted O\nstrongly O\n, O\ntaking O\nthe O\nlead O\nmidway O\nthrough O\nthe O\nfirst O\nhalf O\nwhen O\nformer O\nAuxerre B-ORG\nplaymaker O\nCorentine B-PER\nMartins I-PER\nheaded O\nhome O\na O\ncorner O\nafter O\na O\nflick-on O\nby O\nBrazilian-born B-MISC\nSpanish B-MISC\ninternational O\nmidfielder O\nDonato B-PER\n. O\n\nReal B-ORG\nlooked O\nto O\nbe O\nin O\ndeep O\ntrouble O\nshortly O\nafter O\nthe O\nbreak O\nwhen O\nLuis B-PER\nMilla I-PER\nwas O\nsent O\noff O\nfor O\ncommitting O\ntwo O\nbookable O\noffences O\nin O\nas O\nmany O\nminutes O\n. O\n\nBut O\nDeportivo B-ORG\nwere O\nunable O\nto O\ncapitalise O\non O\ntheir O\nnumerical O\nadvantage O\n, O\nand O\nwere O\nthemselves O\nreduced O\nto O\nten O\nmen O\nwhen O\nArmando B-PER\nAlvarez I-PER\nwas O\nsent O\noff O\n15 O\nminutes O\nfrom O\ntime O\n. O\n\nShortly O\nafterwards O\nRoberto B-PER\nCarlos I-PER\nfound O\nspace O\nin O\nthe O\nhome O\ndefence O\nand O\nequalised O\nfor O\nReal B-ORG\nwith O\na O\nshot O\nthat O\nwas O\ndeflected O\npast O\ndespairing O\nDeportivo B-ORG\n' O\nkeeper O\nJacques B-PER\nSongo'o I-PER\n. O\n\nIn O\na O\nfrantic O\nfinal O\nfive O\nminutes O\nthere O\nwere O\nchances O\nat O\nboth O\nends O\n, O\nand O\nDonato B-PER\n, O\nwho O\nhad O\nearlier O\nbeen O\nbooked O\n, O\nwas O\nsent O\noff O\nfor O\nprotesting O\nabout O\nthe O\nincursion O\nof O\nReal B-ORG\nplayers O\nat O\na O\nfree O\nkick O\n. O\n\nBefore O\nthe O\nmatch O\nDeportivo B-ORG\nchairman O\nAugusto B-PER\nLendoiro I-PER\nsaid O\nhe O\nwould O\nignore O\na O\nFIFA B-ORG\ndecision O\nbanning O\nBrazilian B-MISC\nmidfielder O\nMauro B-PER\nSilva I-PER\nfrom O\nplaying O\nin O\nthe O\nmatch O\nfor O\nfailing O\nto O\njoin O\nhis O\nnational O\nside O\n's O\ntour O\nof O\nEurope B-LOC\n. O\n\nIn O\nthe O\nevent O\n, O\ncoach O\nJohn B-PER\nToshack I-PER\ndecided O\nnot O\nto O\nuse O\nSilva B-PER\n, O\nwho O\nhad O\nclaimed O\nhe O\ndid O\nnot O\njoin O\nthe O\nBrazil B-LOC\nsquad O\nbecause O\nhe O\nhad O\nlost O\nhis O\npassport O\n. O\n\n-DOCSTART- O\n\nRUGBY B-MISC\nLEAGUE I-MISC\n- O\nWIGAN B-ORG\nBEAT O\nBRADFORD B-ORG\n42-36 O\nIN O\nSEMIFINAL O\n. O\n\nWIGAN B-LOC\n, O\nEngland B-LOC\n1996-08-31 O\n\nResult O\nof O\nEnglish B-MISC\nrugby O\nleague O\npremiership O\nsemifinal O\nplayed O\non O\nSaturday O\n: O\n\nWigan B-ORG\n42 O\nBradford B-ORG\nBulls I-ORG\n36 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nISRAEL B-LOC\nBEAT O\nBULGARIA B-LOC\nIN O\nEUROPEAN B-MISC\nUNDER-21 O\nQUALIFIER O\n. O\n\nHERZLIYA B-LOC\n, O\nIsrael B-LOC\n1996-08-31 O\n\nResult O\nof O\nEuropean B-MISC\nunder-21 O\nchampionship O\ngroup O\n5 O\nqualifier O\non O\nSaturday O\n: O\n\nIsrael B-LOC\n2 O\n, O\nBulgaria B-LOC\n0 O\n( O\nhalftime O\n0-0 O\n) O\nScorers O\n: O\nHaim B-PER\nHajaj I-PER\n( O\n47th O\n) O\n, O\nNir B-PER\nSivilia I-PER\n( O\n57th O\n) O\n. O\n\nAttendance O\n: O\n2,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nIRISH B-MISC\nERASE O\nPAINFUL O\nMEMORIES O\nWITH O\n5-0 O\nWIN O\n. O\n\nESCHEN B-LOC\n, O\nLiechtenstein B-LOC\n1996-08-31 O\n\nThe O\nRepublic B-LOC\nof I-LOC\nIreland I-LOC\n's O\nnew-look O\nside O\ndispelled O\npainful O\nmemories O\nof O\ntheir O\nlast O\nvisit O\nto O\nLiechtenstein B-LOC\nby O\nbeating O\nthe O\nAlpine B-MISC\npart-timers O\n5-0 O\nin O\na O\nWorld B-MISC\nCup I-MISC\nqualifier O\non O\nSaturday O\n. O\n\nThe O\nIrish B-MISC\n, O\nunder O\nnew O\nmanager O\nMick B-PER\nMcCarthy I-PER\n, O\ntook O\na O\n4-0 O\nlead O\nwithin O\n20 O\nminutes O\nthrough O\ncaptain O\nAndy B-PER\nTownsend I-PER\n, O\n20-year-old O\nNorwich B-ORG\nstriker O\nKeith B-PER\nO'Neill I-PER\n, O\nSunderland B-ORG\nforward O\nNiall B-PER\nQuinn I-PER\nand O\nteenager O\nIan B-PER\nHarte I-PER\n. O\n\nQuinn B-PER\nadded O\nhis O\nsecond O\nand O\nIreland B-LOC\n's O\nfifth O\njust O\nafter O\nthe O\nhour O\nto O\ncomplete O\nthe O\nrout O\nand O\ngive O\nthe O\nIrish B-MISC\ntheir O\nbiggest-ever O\naway O\nwin O\n. O\n\nThe O\nresult O\nhelped O\nerase O\nmemories O\nof O\nIreland B-LOC\n's O\nvisit O\nto O\nthe O\nEschen B-LOC\nstadium O\n14 O\nmonths O\nago O\n, O\nwhen O\nJack B-PER\nCharlton I-PER\n's O\nside O\nwere O\nheld O\nto O\na O\nfrustrating O\n0-0 O\ndraw O\nwhich O\nultimately O\ncost O\nthem O\na O\nplace O\nin O\nthe O\nEuropean B-MISC\nchampionship O\nfinals O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nIRELAND B-LOC\nBEAT O\nLIECHTENSTEIN B-LOC\n5-0 O\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nESCHEN B-LOC\n1996-08-31 O\n\nThe O\nRepublic B-LOC\nof I-LOC\nIreland I-LOC\nbeat O\nLiechtenstein B-LOC\n5-0 O\n( O\nhalftime O\n4-0 O\n) O\nin O\na O\nWorld B-MISC\nCup I-MISC\nsoccer O\nEuropean B-MISC\ngroup O\n8 O\nqualifier O\non O\nSaturday O\n. O\n\nScorers O\n: O\nAndy B-PER\nTownsend I-PER\n( O\n5th O\n) O\n, O\nKeith B-PER\nO'Neill I-PER\n( O\n7th O\n) O\n, O\nNiall B-PER\nQuinn I-PER\n( O\n11th O\n, O\n61st O\n) O\n, O\nIan B-PER\nHarte I-PER\n( O\n19th O\n) O\n. O\n\nAttendance O\n: O\n3,900 O\n\n-DOCSTART- O\n\nGOLF O\n- O\nBRITISH B-MISC\nMASTERS I-MISC\nFINAL O\nSCORES O\n. O\n\nNORTHAMPTON B-LOC\n, O\nEngland B-LOC\n1996-08-31 O\n\nLeading O\nscores O\nafter O\nthe O\nfinal O\nround O\nof O\nthe O\nBritish B-MISC\nMasters I-MISC\ngolf O\ntournament O\non O\nSaturday O\n( O\nBritish B-MISC\nunless O\nstated O\n) O\n: O\n\n284 O\nRobert B-PER\nAllenby I-PER\n( O\nAustralia B-LOC\n) O\n69 O\n71 O\n71 O\n73 O\n, O\nMiguel B-PER\nAngel I-PER\nMartin I-PER\n( O\nSpain B-LOC\n) O\n75 O\n70 O\n71 O\n68 O\n( O\nAllenby B-PER\nwon O\nat O\nfirst O\nplay-off O\nhole O\n) O\n\n285 O\nCostantino B-PER\nRocca I-PER\n( O\nItaly B-LOC\n) O\n71 O\n73 O\n72 O\n69 O\n\n286 O\nMiguel B-PER\nAngel I-PER\nJimenez I-PER\n( O\nSpain B-LOC\n) O\n74 O\n72 O\n73 O\n67 O\n\n287 O\nIan B-PER\nWoosnam I-PER\n70 O\n76 O\n71 O\n70 O\n\n288 O\nJose B-PER\nCoceres I-PER\n( O\nArgentina B-LOC\n) O\n69 O\n78 O\n71 O\n70 O\n\n289 O\nJoakim B-PER\nHaeggman I-PER\n( O\nSweden B-LOC\n) O\n71 O\n77 O\n70 O\n71 O\n, O\nAntoine B-PER\nLebouc I-PER\n( O\nFrance B-LOC\n) O\n74 O\n73 O\n70 O\n72 O\n\n290 O\nColin B-PER\nMontgomerie I-PER\n68 O\n76 O\n77 O\n69 O\n, O\nRobert B-PER\nColes I-PER\n74 O\n76 O\n71 O\n69 O\n, O\nPhilip B-PER\nWalton I-PER\n( O\nIreland B-LOC\n) O\n71 O\n74 O\n74 O\n71 O\n, O\nPeter B-PER\nMitchell I-PER\n74 O\n71 O\n74 O\n71 O\n, O\nKlas B-PER\nEriksson I-PER\n( O\nSweden B-LOC\n) O\n71 O\n75 O\n72 O\n72 O\n, O\nPedro B-PER\nLinhart I-PER\n( O\nSpain B-LOC\n) O\n72 O\n73 O\n67 O\n78 O\n\n291 O\nPhillip B-PER\nPrice I-PER\n72 O\n76 O\n74 O\n69 O\n, O\nAdam B-PER\nHunter I-PER\n70 O\n79 O\n73 O\n69 O\n, O\nPeter B-PER\nO'Malley I-PER\n( O\nAustralia B-LOC\n) O\n71 O\n73 O\n75 O\n72 O\n, O\nMark B-PER\nRoe I-PER\n69 O\n71 O\n78 O\n73 O\n, O\nMike B-PER\nClayton I-PER\n( O\nAustralia B-LOC\n) O\n69 O\n76 O\n73 O\n73 O\n\n292 O\nIain B-PER\nPyman I-PER\n71 O\n75 O\n75 O\n71 O\n, O\nDavid B-PER\nGilford I-PER\n69 O\n74 O\n77 O\n72 O\n, O\nPeter B-PER\nHedblom I-PER\n( O\nSweden B-LOC\n) O\n70 O\n75 O\n75 O\n72 O\n, O\nStephen B-PER\nMcAllister I-PER\n73 O\n76 O\n69 O\n74 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSLOVAKIA B-LOC\nBEAT O\nFAROES B-LOC\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nTOFTIR B-LOC\n, O\nFaroe B-LOC\nIslands I-LOC\n1996-08-31 O\n\nSlovakia B-LOC\nbeat O\nthe O\nFaroe B-LOC\nIslands I-LOC\n2-1 O\n( O\nhalftime O\n1-0 O\n) O\nin O\ntheir O\nWorld B-MISC\nCup I-MISC\nsoccer O\nEuropean B-MISC\ngroup O\nsix O\nqualifying O\nmatch O\non O\nSaturday O\n. O\n\nScorers O\n: O\n\nFaroe B-LOC\nIslands I-LOC\n- O\nJan B-PER\nAllan I-PER\nMueller I-PER\n( O\n60th O\nminute O\n) O\n\nSlovakia B-LOC\n- O\nLubomir B-PER\nMoravcik I-PER\n( O\n13th O\n) O\n, O\nPeter B-PER\nDubovsky I-PER\n( O\n88th O\n) O\n\nAttendance O\n: O\n1,445 O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nBEAT O\nPAKISTAN B-LOC\nBY O\n107 O\nRUNS O\nIN O\nSECOND O\nONE-DAYER O\n. O\n\nBIRMINGHAM B-LOC\n, O\nEngland B-LOC\n1996-08-31 O\n\nEngland B-LOC\nbeat O\nPakistan B-LOC\nby O\n107 O\nruns O\nin O\nthe O\nsecond O\none-day O\ninternational O\nat O\nEdgbaston B-LOC\non O\nSaturday O\nto O\ntake O\nthe O\nseries O\n2-0 O\n. O\n\nScores O\n: O\nEngland B-LOC\n292-8 O\ninnings O\nclosed O\n( O\nN. B-PER\nKnight I-PER\n113 O\n) O\n, O\nPakistan B-LOC\n185 O\n( O\nIjaz B-PER\nAhmed I-PER\n79 O\n; O\nA. B-PER\nHollioake I-PER\n4-23 O\n) O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nTOUR B-MISC\nOF I-MISC\nNETHERLANDS I-MISC\nFINAL O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nLANDGRAAF B-LOC\n, O\nNetherlands B-LOC\n1996-08-31 O\n\nLeading O\nresults O\nof O\n\nthe O\n205-km O\nsixth O\nand O\nfinal O\nstage O\nof O\nthe O\nTour B-MISC\nof I-MISC\nthe I-MISC\nNetherlands I-MISC\n\nbetween O\nRoermond B-LOC\nand O\nLandgraaf B-LOC\non O\nSaturday O\n: O\n\n1. O\nOlaf B-PER\nLudwig I-PER\n( O\nGermany B-LOC\n) O\nTelekom B-ORG\n4 O\nhours O\n48 O\nmins O\n2 O\nseconds O\n\n2. O\nGiovanni B-PER\nLombardi I-PER\n( O\nItaly B-LOC\n) O\nPolti B-ORG\n5 O\nseconds O\nbehind O\n\n3. O\nTristan B-PER\nHoffman I-PER\n( O\nNetherlands B-LOC\n) O\nTVM B-ORG\nsame O\ntime O\n\n4. O\nErik B-PER\nBreukink I-PER\n( O\nNetherlands B-LOC\n) O\nRabobank B-ORG\n8 O\nseconds O\n\n5. O\nJesper B-PER\nSkibby I-PER\n( O\nDenmark B-LOC\n) O\nTVM B-ORG\n9 O\n\n6. O\nVyacheslav B-PER\nEkimov I-PER\n( O\nRussia B-LOC\n) O\nRabobank B-ORG\nsame O\ntime O\n\n7. O\nLuca B-PER\nPavanello I-PER\n( O\nItaly B-LOC\n) O\nAki B-PER\n11 O\n\n8. O\nEleuterio B-PER\nAnguita I-PER\n( O\nSpain B-LOC\n) O\nMX B-ORG\nOnda I-ORG\n\n9. O\nMichael B-PER\nAndersson I-PER\n( O\nSweden B-LOC\n) O\nTelekom B-ORG\n\n10. O\nJohan B-PER\nCapiot I-PER\n( O\nBelgium B-LOC\n) O\nCollstrop B-ORG\nall O\nsame O\ntime O\n\nFinal O\noverall O\nplacings O\n( O\nafter O\nsix O\nstages O\n) O\n: O\n\n1. O\nRolf B-PER\nSorensen I-PER\n( O\nDenmark B-LOC\n) O\nRabobank B-ORG\n20:36:54 O\n\n2. O\nLance B-PER\nArmstrong I-PER\n( O\nU.S. B-LOC\n) O\nMotorola B-ORG\n2 O\nseconds O\nbehind O\n\n3. O\nEkimov B-PER\n1:7 O\n\n4. O\nMarco B-PER\nLietti I-PER\n( O\nItaly B-LOC\n) O\nMG-Technogym B-ORG\n1:16 O\n\n5. O\nErik B-PER\nDekker I-PER\n( O\nNetherlands B-LOC\n) O\nRabobank B-ORG\n1:23 O\n\n6. O\nLudwig B-PER\n1:25 O\n\n6. O\nBreukink B-PER\nsame O\ntime O\n\n8. O\nMaarten B-PER\nden I-PER\nBakker I-PER\n( O\nNetherlands B-LOC\n) O\nTVM B-ORG\n1:33 O\n\n9. O\nAndersson B-PER\n1:34 O\n\n10. O\nSkibby B-PER\n1:45 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nV O\nPAKISTAN B-LOC\nONE-DAY O\nSCOREBOARD O\n. O\n\nBIRMINGHAM B-ORG\n, O\nEngland B-LOC\n1996-08-31 O\n\nScoreboard O\nof O\nthe O\nsecond O\none-day O\ncricket O\nmatch O\nbetween O\nEngland B-LOC\nand O\nPakistan B-LOC\non O\nSaturday O\n: O\n\nEngland B-LOC\n\nN. B-PER\nKnight I-PER\nst O\nMoin B-PER\nKhan I-PER\nb O\nSaqlain B-PER\nMushtaq I-PER\n113 O\n\nA. B-PER\nStewart I-PER\nb O\nMushtaq B-PER\nAhmed I-PER\n46 O\n\nM. B-PER\nAtherton I-PER\nlbw O\nb O\nMushtaq B-PER\nAhmed I-PER\n1 O\n\nG. B-PER\nThorpe I-PER\nlbw O\nb O\nAta-ur-Rehman B-PER\n21 O\n\nM. B-PER\nMaynard I-PER\nrun O\nout O\n1 O\n\nR. B-PER\nIrani I-PER\nnot O\nout O\n45 O\n\nA. B-PER\nHollioake I-PER\nrun O\nout O\n15 O\n\nD. B-PER\nGough I-PER\nrun O\nout O\n0 O\n\nR. B-PER\nCroft I-PER\nb O\nWaqar B-PER\nYounis I-PER\n15 O\n\nD. B-PER\nHeadley I-PER\nnot O\nout O\n3 O\n\nExtras O\n( O\nlb-25 O\nw-4 O\nnb-3 O\n) O\n32 O\n\nTotal O\n( O\nfor O\n8 O\nwickets O\n, O\ninnings O\nclosed O\n) O\n292 O\n\nFall O\n: O\n1-103 O\n2-105 O\n3-163 O\n4-168 O\n5-221 O\n6-257 O\n7-257 O\n8-286 O\n. O\n\nDid O\nNot O\nBat O\n: O\nA. B-PER\nMullally I-PER\n. O\n\nBowling O\n: O\nWasim B-PER\nAkram I-PER\n10-0-50-0 O\n, O\nWaqar B-PER\nYounis I-PER\n9-0-54-1 O\n, O\n\nAta-ur-Rehman B-PER\n6-0-40-1 O\n, O\nSaqlain B-PER\nMushtaq I-PER\n10-0-59-1 O\n, O\nMushtaq B-PER\nAhmed I-PER\n\n10-0-33-2 O\n, O\nAamir B-PER\nSohail I-PER\n5-0-31-0 O\n. O\n\npakistan O\n\nSaeed B-PER\nAnwar I-PER\nc O\nStewart B-PER\nb O\nGough B-PER\n33 O\n\nAamir B-PER\nSohail I-PER\nc O\nCroft B-PER\nb O\nGough B-PER\n0 O\n\nMoin B-PER\nKhan I-PER\nlbw O\nb O\nMullally B-PER\n0 O\n\nIjaz B-PER\nAhmed I-PER\nb O\nCroft B-PER\n79 O\n\nInzamam-ul-Haq B-PER\nc O\nThorpe B-PER\nb O\nCroft B-PER\n6 O\n\nSalim B-PER\nMalik I-PER\nc O\nStewart B-PER\nb O\nHollioake B-PER\n23 O\n\nWasim B-PER\nAkram I-PER\nc O\nKnight B-PER\nb O\nHollioake B-PER\n21 O\n\nMushtaq B-PER\nAhmed I-PER\nnot O\nout O\n14 O\n\nSaqlain B-PER\nMushtaq I-PER\nb O\nHollioake B-PER\n0 O\n\nWaqar B-PER\nYounis I-PER\nlbw O\nb O\nGough B-PER\n4 O\n\nAta-ur-Rehman B-PER\nc O\nKnight B-PER\nb O\nHollioake B-PER\n2 O\n\nExtras O\n( O\nlb-2 O\nnb-1 O\n) O\n3 O\n\nTotal O\n( O\n37.5 O\novers O\n) O\n185 O\n\nFall O\nof O\nwickets O\n: O\n1-1 O\n2-6 O\n3-54 O\n4-104 O\n5-137 O\n6-164 O\n7-164 O\n8-168 O\n\n9-177 O\n. O\n\nBowling O\n: O\nGough B-PER\n8-0-39-3 O\n, O\nMullally B-PER\n6-0-30-1 O\n, O\nHeadley B-PER\n\n7-0-32-0 O\n, O\nIrani B-PER\n2-0-22-0 O\n, O\nCroft B-PER\n8-0-37-2 O\n, O\nHollioake B-PER\n6.5-1-23-4 O\n. O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nWORLD O\nTRACK O\nCHAMPIONSHIP O\nRESULTS O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-31 O\n\nResults O\nat O\nthe O\nworld O\n\ntrack O\ncycling O\nchampionships O\non O\nSaturday O\n: O\n\nWomen O\n's O\n3,000 O\nmetres O\nindividual O\npursuit O\nqualifying O\nround O\n\n( O\nfastest O\neight O\nto O\nquarter O\nfinals O\n) O\n: O\n\n1. O\nAntonella B-PER\nBellutti I-PER\n( O\nItaly B-LOC\n) O\n3:31.526 O\n( O\nworld O\nrecord O\n) O\n\n2. O\nMarion B-PER\nClignet I-PER\n( O\nFrance B-LOC\n) O\n3:31.674 O\n\n3. O\nLucy B-PER\nTyler-Sharman I-PER\n( O\nAustralia B-LOC\n) O\n3:31.830 O\n\n4. O\nYvonne B-PER\nMcGregor I-PER\n( O\nBritain B-LOC\n) O\n3:41.823 O\n\n5. O\nNatalia B-PER\nKarimova I-PER\n( O\nRussia B-LOC\n) O\n3:45.061 O\n\n6. O\nSvetlana B-PER\nSamokhalova I-PER\n( O\nRussia B-LOC\n) O\n3:46.216 O\n\n7 O\nJane B-PER\nQuigley I-PER\n( O\nU.S. B-LOC\n) O\n3:46.493 O\n\n8. O\nRasa B-PER\nMazeikyte I-PER\n( O\nLithuania B-LOC\n) O\n3:46.834 O\n\n9. O\nTatian B-PER\nStiajkina I-PER\n( O\nUkraine B-LOC\n) O\n3:52.204 O\n\nWorld O\n4,000 O\nmetres O\nteam O\npursuit O\nsemifinals O\n: O\n\nItaly B-LOC\n( O\nAdler B-PER\nCapelli I-PER\n, O\nCristiano B-PER\nCitto I-PER\n, O\nAndrea B-PER\nCollinelli I-PER\n, O\nMauro B-PER\nTrentino I-PER\n) O\n4:00.958 O\n( O\nworld O\nrecord O\n) O\nbeat O\nRussia B-LOC\n( O\nAnton B-PER\nChantyr I-PER\n, O\nEdouard B-PER\nGritsoun I-PER\n, O\nNikolai B-PER\nKouznetsov I-PER\n) O\n4:06.534 O\n. O\n\nFrance B-LOC\n( O\nCyril B-PER\nBos I-PER\n, O\nPhilippe B-PER\nErmenault I-PER\n, O\nJean-Michel B-PER\nMonin I-PER\n, O\nFrancis B-PER\nMoreau I-PER\n) O\n4:05.104 O\nbeat O\nGermany B-LOC\n( O\nGuido B-PER\nFulst I-PER\n, O\nDanilo B-PER\nHondo I-PER\n, O\nThorsten B-PER\nRund I-PER\n, O\nHeiko B-PER\nSzonn I-PER\n) O\n4:05.463 O\n\nGermany B-LOC\ntake O\nthe O\nbronze O\nmedal O\nas O\nfastest O\nlosing O\nsemifinalist O\n. O\n\nWomen O\n's O\nworld O\n500 O\nmetres O\ntime O\ntrial O\nfinal O\n: O\n\n1. O\nFelicia B-PER\nBallanger I-PER\n( O\nFrance B-LOC\n) O\n34.829 O\n\n2. O\nAnnett B-PER\nNeumann I-PER\n( O\nGermany B-LOC\n) O\n35.202 O\n\n3. O\nMichelle B-PER\nFerris I-PER\n( O\nAustralia B-LOC\n) O\n35.694 O\n\n4. O\nMagali B-PER\nFaure I-PER\n( O\nFrance B-LOC\n) O\n35.888 O\n\n5. O\nOlga B-PER\nSlioussareva I-PER\n( O\nRussia B-LOC\n) O\n36.170 O\n\n6. O\nOksana B-PER\nGrichina I-PER\n( O\nRussia B-LOC\n) O\n36.242 O\n\n7. O\nTanya B-PER\nDubnicoff I-PER\n( O\nCanada B-LOC\n) O\n36.307 O\n\n8. O\nKathrin B-PER\nFreitag I-PER\n( O\nGermany B-LOC\n) O\n36.491 O\n\n9. O\nDonna B-PER\nWynd I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n36.831 O\n\n10. O\nMira B-PER\nKasslin I-PER\n( O\nFinland B-LOC\n) O\n37.273 O\n\n11. O\nWendy B-PER\nEverson I-PER\n( O\nBritain B-LOC\n) O\n37.624 O\n\n12. O\nGiovanna B-PER\nTroldi I-PER\n( O\nItaly B-LOC\n) O\n38.285 O\n\n13. O\nRita B-PER\nRazmaite I-PER\n( O\nLithuania B-LOC\n) O\n38.546 O\n\nWorld O\n4,000 O\nmetres O\nteam O\npursuit O\nchampionship O\nfinal O\n: O\n\nItaly B-LOC\n( O\nAdler B-PER\nCapelli I-PER\n, O\nCristiano B-PER\nCitto I-PER\n, O\nAndrea B-PER\nCollinelli I-PER\n, O\nMauro B-PER\nTrentino I-PER\n) O\n4:02.752 O\nbeat O\nFrance B-LOC\n( O\nCyril B-PER\nBos I-PER\n, O\nPhilippe B-PER\nErmenault I-PER\n, O\nJean-Michel B-PER\nMonin I-PER\n, O\nFrancis B-PER\nMoreau I-PER\n) O\n4:04.539 O\n\nWorld O\nsprint O\nchampionship O\nquarter O\nfinals O\n( O\nbest O\nof O\nthree O\n\nmatches O\n) O\n\nFlorian B-PER\nRousseau I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nAinars B-PER\nKiksis I-PER\n( O\nLatvia B-LOC\n) O\n2-0 O\n\nDarryn B-PER\nHill I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nChristian B-PER\nArrue I-PER\n( O\nU.S. B-LOC\n) O\n2-0 O\n\nRoberto B-PER\nChiappa I-PER\n( O\nItaly B-LOC\n) O\nbeat O\nFrederic B-PER\nMagne I-PER\n( O\nFrance B-LOC\n) O\n2-0 O\n\nMarty B-PER\nNothstein I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nPavel B-PER\nBuran I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n2-0 O\n\nWomen O\n's O\nworld O\n3,000 O\nmetres O\nindividual O\npursuit O\nchampionship O\n\nquarter-finals O\n: O\n\nMarion B-PER\nClignet I-PER\n( O\nFrance B-LOC\n) O\n3:30.974 O\n( O\nWorld O\nRecord O\n) O\nbeat O\nJane B-PER\n\nQuigley B-PER\n( O\nUSA B-LOC\n) O\n3:42.852 O\n\nNatalia B-PER\nKarimova I-PER\n( O\nRussia B-LOC\n) O\n3:40.036 O\nbeat O\nYvonne B-PER\nMcGregor I-PER\n\n( O\nBritain B-LOC\n) O\n3:43.078 O\n\nLucy B-PER\nTyler-Sharman I-PER\n( O\nAustralia B-LOC\n) O\n3:35.087 O\nbeat O\nSvetlana B-PER\n\nSamokhvalova B-PER\n( O\nRussia B-LOC\n) O\n3:45.011 O\n\nAntonella B-PER\nBellutti I-PER\n( O\nItaly B-LOC\n) O\n3:32.174 O\ncaught O\nand O\neliminated O\nRasa B-PER\n\nMazeikyte B-PER\n( O\nLithuania B-LOC\n) O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\nWIN O\nTOSS O\n, O\nPUT O\nENGLAND B-LOC\nIN O\nTO O\nBAT O\n. O\n\nBIRMINGHAM B-LOC\n, O\nEngland B-LOC\n1996-08-31 O\n\nPakistan B-LOC\nwon O\nthe O\ntoss O\nand O\nput O\nEngland B-LOC\nin O\nto O\nbat O\nin O\nthe O\nsecond O\nlimited O\novers O\ncricket O\ninternational O\nat O\nEdgbaston B-LOC\non O\nSaturday O\n. O\n\nSurrey B-ORG\nall-rounder O\nAdam B-PER\nHollioake I-PER\nwas O\nmaking O\nhis O\nEngland B-LOC\ndebut O\n, O\nreplacing O\nLancashire B-ORG\nbatsman O\nGraham B-PER\nLloyd I-PER\n, O\nwith O\nseamer O\nPeter B-PER\nMartin I-PER\nagain O\nbeing O\nomitted O\nfrom O\nthe O\n13 O\n. O\n\nPakistan B-LOC\nkept O\nthe O\nside O\nwho O\nlost O\nto O\nEngland B-LOC\nby O\nfive O\nwickets O\nat O\nOld B-LOC\nTrafford I-LOC\non O\nThursday O\nin O\nthe O\nfirst O\nof O\nthe O\nthree O\none-day O\nmatches O\n. O\n\nTeams O\n: O\n\nEngland B-LOC\n: O\nMike B-PER\nAtherton I-PER\n( O\ncaptain O\n) O\n, O\nNick B-PER\nKnight I-PER\n, O\nAlec B-PER\nStewart I-PER\n, O\nGraham B-PER\nThorpe I-PER\n, O\nMatthew B-PER\nMaynard I-PER\n, O\nAdam B-PER\nHollioake I-PER\n, O\nRonnie B-PER\nIrani I-PER\n, O\nRobert B-PER\nCroft I-PER\n, O\nDarren B-PER\nGough I-PER\n, O\nDean B-PER\nHeadley I-PER\n, O\nAlan B-PER\nMullally I-PER\n. O\n\nPakistan B-LOC\n: O\nAamir B-PER\nSohail I-PER\n, O\nSaeed B-PER\nAnwar I-PER\n, O\nIjaz B-PER\nAhmed I-PER\n, O\nSalim B-PER\nMalik I-PER\n, O\nInzamam-ul-Haq B-PER\n, O\nWasim B-PER\nAkram I-PER\n( O\ncaptain O\n) O\n, O\nMoin B-PER\nKhan I-PER\n, O\nSaqlain B-PER\nMushtaq I-PER\n, O\nMushtaq B-PER\nAhmed I-PER\n, O\nWaqar B-PER\nYounis I-PER\n, O\nAta-ur-Rehman B-PER\n. O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nGONZALEZ B-PER\nHOMERS O\nTWICE O\nAS O\nRANGERS B-ORG\nBEAT O\nINDIANS B-ORG\n. O\n\nARLINGTON B-LOC\n, O\nTexas B-LOC\n1996-08-31 O\n\nJuan B-PER\nGonzalez I-PER\nhomered O\ntwice O\nand O\nIvan B-PER\nRodriguez I-PER\nadded O\na O\ntwo-run O\nshot O\nas O\nthe O\nTexas B-ORG\nRangers I-ORG\ndefeated O\nthe O\nCleveland B-ORG\nIndians I-ORG\n5-3 O\nin O\na O\nmatchup O\nof O\ndivision O\nleaders O\nFriday O\n. O\n\nRodriguez B-PER\n's O\n18th O\nhomer O\n, O\noff O\nChad B-PER\nOgea I-PER\n( O\n7-5 O\n) O\nin O\nthe O\nfirst O\n, O\ngave O\nTexas B-LOC\na O\n2-0 O\nlead O\n. O\n\nOne O\nout O\nlater O\n, O\nGonzalez B-PER\nsmacked O\nhis O\n40th O\nhomer O\n, O\nextending O\nhis O\nhitting O\nstreak O\nto O\n20 O\ngames O\n. O\n\nGonzalez B-PER\n, O\nwho O\nhit O\nin O\n21 O\nstraight O\ngames O\nearlier O\nthis O\nseason O\n, O\njoined O\nMickey B-PER\nRivers I-PER\nas O\nthe O\nonly O\nplayers O\nin O\nTexas B-LOC\nhistory O\nwith O\ntwo O\n20-game O\nstreaks O\nin O\nthe O\nsame O\nyear O\n. O\n\nGonzalez B-PER\nhit O\nhis O\nsecond O\nhomer O\nin O\nthe O\nthird O\nfor O\nhis O\nfifth O\nmulti-homer O\ngame O\nof O\nthe O\nseason O\n. O\n\nGonzalez B-PER\nhas O\nthree O\n40-homer O\nseasons O\nand O\nhis O\n121 O\nRBI B-MISC\nbroke O\nRuben B-PER\nSierra I-PER\n's O\nteam O\nrecord O\nof O\n119 O\nset O\nin O\n1989 O\n. O\n\nThe O\nIndians B-MISC\nhad O\ntheir O\nfour-game O\nwinning O\nstreak O\nstopped O\n. O\n\n\" O\nIt O\n's O\nnot O\nsomething O\nI O\n'm O\ngoing O\nto O\ntry O\nto O\nexplain O\n, O\n\" O\nsaid O\nTexas B-LOC\nmanager O\nJohnny B-PER\nOates I-PER\nabout O\nhis O\nteam O\nwinning O\nseven O\nof O\nthe O\n10 O\nmeetings O\nfrom O\nCleveland B-ORG\nthis O\nseason O\n. O\n\n\" O\nWe O\n've O\ngot O\ntwo O\nmore O\nregular O\nseason O\ngames O\nagainst O\nthem O\nand O\nwe O\nmight O\nget O\nlucky O\nenough O\nor O\nunlucky O\nenough O\nto O\nplay O\nthem O\nin O\nthe O\npost-season O\n. O\n\" O\n\nRoger B-PER\nPavlik I-PER\n( O\n15-7 O\n) O\ngave O\nup O\nthree O\nruns O\nand O\nseven O\nhits O\nin O\n6 O\n1/3 O\ninnings O\nand O\nbecame O\nthe O\nfourth O\n15-game O\nwinner O\nin O\nthe O\nAmerican B-MISC\nLeague I-MISC\n. O\n\nJeff B-PER\nRussell I-PER\npitched O\ntwo O\nperfect O\ninnings O\nfor O\nhis O\nthird O\nsave O\n. O\n\nBrian B-PER\nGiles I-PER\nand O\nJim B-PER\nThome I-PER\nhomered O\nfor O\nCleveland B-ORG\n. O\n\nCleveland B-ORG\n's O\nlead O\nover O\nthe O\nWhite B-ORG\nSox I-ORG\nin O\nthe O\nAmerican B-MISC\nLeague I-MISC\nCentral I-MISC\ndropped O\nto O\nnine O\ngames O\n. O\n\nTexas B-ORG\n's O\nlead O\nover O\nSeattle B-ORG\nin O\nthe O\nWest B-LOC\nincreased O\nto O\nsix O\n. O\n\nAt O\nCalifornia B-LOC\n, O\nTino B-PER\nMartinez I-PER\n's O\ntwo-run O\nhomer O\nkeyed O\na O\nthree-run O\nfirst O\nand O\nAndy B-PER\nPettitte I-PER\nbecame O\nthe O\nleague O\n's O\nfirst O\n19-game O\nwinner O\nas O\nthe O\nNew B-ORG\nYork I-ORG\nYankees I-ORG\nbeat O\nthe O\nAngels B-ORG\n6-2 O\n. O\n\nNew B-LOC\nYork I-LOC\nsnapped O\na O\nseason-high O\nfive-game O\nlosing O\nstreak O\nand O\nalso O\ngot O\nhomers O\nfrom O\nMariano B-PER\nDuncan I-PER\n, O\nDarryl B-PER\nStrawberry I-PER\nand O\nJim B-PER\nLeyritz I-PER\n. O\n\nPettite B-PER\n( O\n19-7 O\n) O\nallowed O\ntwo O\nruns O\nand O\neight O\nhits O\nover O\neight O\ninnings O\nwith O\na O\nwalk O\nand O\nseven O\nstrikeouts O\n. O\n\nHe O\nimproved O\nto O\n12-2 O\nfollowing O\nYankees B-ORG\n' O\nlosses O\n. O\n\nMariano B-PER\nRivera I-PER\npitched O\na O\nscoreless O\nninth O\n, O\nstriking O\nout O\ntwo O\n. O\n\nEx-Yankee O\nRandy B-PER\nVelarde I-PER\nhit O\nhis O\n11th O\nhomer O\n, O\nhis O\nmost O\nat O\nany O\nprofessional O\nlevel O\n. O\n\nIn O\nSeattle B-LOC\n, O\nPete B-PER\nIncaviglia I-PER\n's O\ngrand O\nslam O\nwith O\none O\nout O\nin O\nthe O\nsixth O\nsnapped O\na O\ntie O\nand O\nlifted O\nthe O\nBaltimore B-ORG\nOrioles I-ORG\npast O\nthe O\nSeattle B-ORG\nMariners I-ORG\n, O\n5-2 O\n. O\n\nIt O\nwas O\nIncaviglia B-PER\n's O\nsixth O\ngrand O\nslam O\nand O\n200th O\nhomer O\nof O\nhis O\ncareer O\n. O\n\nBaltimore B-ORG\n's O\nEddie B-PER\nMurray I-PER\ncracked O\nhis O\n20th O\nhomer O\nof O\nthe O\nseason O\nand O\n499th O\nof O\nhis O\ncareer O\n. O\n\nJay B-PER\nBuhner I-PER\nhit O\nhis O\n38th O\nhomer O\nand O\nEdgar B-PER\nMartinez I-PER\nhis O\n23rd O\nfor O\nSeattle B-ORG\n. O\n\nThe O\nOrioles B-ORG\nremained O\ntied O\nwith O\nthe O\nWhite B-ORG\nSox I-ORG\nfor O\nthe O\nAmerican B-MISC\nLeague I-MISC\nwild O\ncard O\nwith O\nthe O\nMariners B-ORG\na O\ngame O\nback O\n. O\n\nIn O\nToronto B-LOC\n, O\nKevin B-PER\nTapani I-PER\n( O\n12-8 O\n) O\nallowed O\ntwo O\nruns O\nand O\nsix O\nhits O\nover O\n7 O\n1/3 O\ninnings O\nand O\nFrank B-PER\nThomas I-PER\nhit O\nhis O\n29th O\nhomer O\nand O\ndrove O\nin O\nthree O\nruns O\nas O\nthe O\nChicago B-ORG\nWhite I-ORG\nSox I-ORG\ncruised O\nto O\nan O\n11-2 O\nvictory O\nover O\nthe O\nBlue B-ORG\nJays I-ORG\n. O\n\nThomas B-PER\n, O\nHarold B-PER\nBaines I-PER\nand O\nRobin B-PER\nVentura I-PER\neach O\ncollected O\nthree O\nhits O\n. O\n\nBaines B-PER\nhomered O\nand O\nscored O\nthree O\nruns O\n. O\n\nDanny B-PER\nTartabull I-PER\nadded O\ntwo O\nhits O\nand O\nthree O\nRBI B-MISC\nas O\nall O\nChicago B-LOC\nstarters O\ngot O\nat O\nleast O\none O\nhit O\n. O\n\nIn O\nOakland B-LOC\n, O\nDave B-PER\nTelgheder I-PER\nscattered O\nseven O\nhits O\nover O\neight O\ninnings O\nand O\nMark B-PER\nMcGwire I-PER\nhit O\nhis O\nmajor-league O\nleading O\n45th O\nhomer O\nand O\ndrove O\nin O\nthree O\nruns O\nas O\nthe O\nAthetlics B-ORG\nblanked O\nthe O\nBoston B-ORG\nRed I-ORG\nSox I-ORG\n7-0 O\n. O\n\nTelgheder B-PER\n( O\n2-5 O\n) O\nsnapped O\na O\npersonal O\nthree-game O\nlosing O\nstreak O\n. O\n\nBuddy B-PER\nGroom I-PER\npitched O\na O\nperfect O\nninth O\ninning O\n. O\n\nMcGwire B-PER\nsingled O\nhome O\na O\nrun O\nto O\nspark O\na O\nthree-run O\nsixth O\nand O\ncapped O\nthe O\nscoring O\nwith O\na O\ntwo-run O\nhomer O\nin O\nthe O\nseventh O\n. O\n\nThe O\nloss O\nwas O\nBoston B-ORG\n's O\nseventh O\nin O\nits O\nlast O\n29 O\ngames O\n. O\n\nIn O\nDetroit B-LOC\n, O\nTodd B-PER\nVan I-PER\nPoppel I-PER\npitched O\na O\nfive-hitter O\nfor O\nhis O\nfirst O\ncareer O\nshutout O\nand O\nTony B-PER\nClark I-PER\nhomered O\nto O\ncap O\na O\nfour-run O\nfirst O\ninning O\nas O\nthe O\nTigers B-ORG\nblanked O\nthe O\nKansas B-ORG\nCity I-ORG\nRoyals I-ORG\n4-0 O\n. O\n\nVan B-PER\nPoppel I-PER\n( O\n3-6 O\n) O\nwalked O\ntwo O\nand O\nstruck O\nout O\ntwo O\nin O\ndefeating O\nthe O\nRoyals B-ORG\nfor O\nthe O\nsecond O\ntime O\nthis O\nweek O\n. O\n\nHe O\nthrew O\n108 O\npitches O\nas O\nhe O\nlowered O\nhis O\nERA B-MISC\nfrom O\n8.08 O\nto O\n7.24 O\n. O\n\nKansas B-LOC\nCity I-LOC\nhas O\nscored O\nonly O\none O\nrun O\nin O\ntwo O\ngames O\n. O\n\nIn O\nMilwaukee B-LOC\n, O\nMarc B-PER\nNewfield I-PER\nhomered O\noff O\nJose B-PER\nParra I-PER\n( O\n5-4 O\n) O\nleading O\noff O\nthe O\nbottom O\nof O\nthe O\n12th O\nas O\nthe O\nBrewers B-ORG\nrallied O\nfor O\na O\n5-4 O\nvictory O\nover O\nthe O\nMinnesota B-ORG\nTwins I-ORG\n. O\n\nMilwaukee B-ORG\nhas O\nwon O\n10 O\nof O\nits O\nlast O\n15 O\n. O\n\nBob B-PER\nWickman I-PER\n( O\n6-1 O\n) O\npitched O\n2 O\n2/3 O\nhitless O\ninnings O\nfor O\nthe O\nwin O\n, O\nhis O\nsecond O\nfor O\nthe O\nBrewers B-ORG\n. O\n\nMatt B-PER\nLawton I-PER\nhit O\na O\nthree-run O\nhomer O\noff O\ncloser O\nMike B-PER\nFetters I-PER\nwith O\none O\nout O\nin O\nthe O\nninth O\nto O\ngive O\nMinnesota B-ORG\na O\n4-2 O\nlead O\n. O\n\nBut O\nMilwaukee B-ORG\ntied O\nit O\nup O\nin O\nthe O\nbottom O\nof O\nthe O\nninth O\non O\npinch-hitter O\nDave B-PER\nNilsson I-PER\n's O\ntwo-run O\ndouble O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nESSEX B-ORG\nAND O\nKENT B-ORG\nMADE O\nTO O\nSWEAT O\nIN O\nTITLE O\nRACE O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nEssex B-ORG\nand O\nKent B-ORG\nboth O\nface O\ntense O\nfinishes O\non O\nMonday O\nas O\nthey O\nattempt O\nto O\nkeep O\npace O\nwith O\ntitle O\nhopefuls O\nDerbyshire B-ORG\nand O\nSurrey B-ORG\n, O\nconvincing O\nthree-day O\nvictors O\non O\nSaturday O\n, O\nin O\nthe O\nEnglish B-MISC\ncounty O\nchampionship O\nrun-in O\n. O\n\nEssex B-ORG\nneed O\nanother O\n148 O\nwith O\nfive O\nwickets O\nin O\nhand O\nto O\nbeat O\nYorkshire B-ORG\nafter O\na O\nmaiden O\nfirst-class O\ncentury O\nfrom O\nRichard B-PER\nKettleborough I-PER\ntransformed O\na O\nmatch O\nwhich O\nhis O\nside O\nhad O\nseemed O\ncertain O\nto O\nlose O\n. O\n\nKent B-ORG\nwill O\nalso O\nneed O\nto O\nkeep O\ntheir O\nnerve O\nagainst O\nstruggling O\nNottinghamshire B-ORG\nwho O\nwill O\nenter O\nthe O\nfinal O\nday O\n137 O\nahead O\nwith O\nfour O\nwickets O\nleft O\nin O\na O\nrelatively O\nlow-scoring O\nmatch O\nat O\nTunbridge B-LOC\nWells I-LOC\n. O\n\nDerbyshire B-ORG\n, O\nnine-wicket O\nwinners O\nover O\nWorcestershire B-ORG\n, O\nand O\nSurrey B-ORG\n, O\nwho O\nthrashed O\nWarwickshire B-ORG\nby O\nan O\ninnings O\nand O\n164 O\nruns O\n, O\ncan O\ninstead O\ntake O\nthe O\nday O\noff O\nalong O\nwith O\nrivals O\nLeicestershire B-ORG\n, O\nwho O\nbeat O\nSomerset B-ORG\ninside O\ntwo O\ndays O\n. O\n\nWarwickshire B-ORG\ncaptain O\nTim B-PER\nMunton I-PER\nis O\ntipping O\nSurrey B-ORG\nto O\nemerge O\non O\ntop O\n, O\nimpressed O\nby O\nthe O\npositive O\ninfluence O\nof O\nAustralian B-MISC\ncoach O\nDave B-PER\nGilbert I-PER\n, O\nbut O\nDerbyshire B-ORG\n's O\nAustralian B-MISC\ncaptain O\nDean B-PER\nJones I-PER\nis O\nconceding O\nnothing O\nas O\nhis O\nside O\nchase O\ntheir O\nfirst O\ntitle O\nfor O\n60 O\nyears O\n. O\n\n\" O\nWe O\ntook O\nthree O\nabsolutely O\nbrilliant O\ncatches O\nin O\nthis O\nmatch O\nand O\nour O\ncatching O\nall O\nseason O\nhas O\nbeen O\npretty O\nimpressive O\n. O\n\nOur O\ncatching O\nwill O\nwin O\nor O\nlose O\nus O\nthe O\nchampionship O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nLEADING O\nMONEY O\nWINNERS O\nON O\nEUROPEAN B-MISC\nTOUR I-MISC\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nLeading O\nmoney O\nwinners O\non O\nthe O\n\nEuropean B-MISC\nTour I-MISC\nafter O\nthe O\nBritish B-MISC\nMasters I-MISC\nwon O\nby O\nRobert B-PER\nAllenby I-PER\non O\n\nSaturday O\n( O\nBritish B-MISC\nunless O\nstated O\n) O\n: O\n\n1. O\nIan B-PER\nWoosnam I-PER\n510,258 O\npounds O\nsterling O\n\n2. O\nColin B-PER\nMontgomerie I-PER\n442,201 O\n\n3. O\nRobert B-PER\nAllenby I-PER\n( O\nAustralia B-LOC\n) O\n407,748 O\n\n4. O\nLee B-PER\nWestwood I-PER\n301,972 O\n\n5. O\nCostantino B-PER\nRocca I-PER\n( O\nItaly B-LOC\n) O\n297,157 O\n\n6. O\nMark B-PER\nMcNulty I-PER\n( O\nZimbabwe B-LOC\n) O\n254,247 O\n\n7. O\nAndrew B-PER\nColtart I-PER\n248,142 O\n\n8. O\nWayne B-PER\nRiley I-PER\n( O\nAustralia B-LOC\n) O\n239,733 O\n\n9. O\nRaymond B-PER\nRussell I-PER\n234,330 O\n\n10. O\nPaul B-PER\nLawrie I-PER\n211,420 O\n\n11. O\nStephen B-PER\nAmes I-PER\n( O\nTrinidad B-LOC\n) O\n211,175 O\n\n12. O\nFrank B-PER\nNobilo I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n209,412 O\n\n13. O\nPaul B-PER\nMcGinley I-PER\n( O\nIreland B-LOC\n) O\n208,978 O\n\n14. O\nPadraig B-PER\nHarrington I-PER\n( O\nIreland B-LOC\n) O\n202,593 O\n\n15. O\nRetief B-PER\nGoosen I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n195,283 O\n\n16. O\nMiguel B-PER\nAngel I-PER\nJimenez I-PER\n( O\nSpain B-LOC\n) O\n184,180 O\n\n17. O\nPeter B-PER\nMitchell I-PER\n183,704 O\n\n18. O\nMiguel B-PER\nAngel I-PER\nMartin I-PER\n( O\nSpain B-LOC\n) O\n182,533 O\n\n19. O\nJonathan B-PER\nLomas I-PER\n181,005 O\n\n20. O\nPaul B-PER\nBroadhurst I-PER\n176,780 O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nENGLISH B-MISC\n, O\nSCOTTISH B-MISC\nAND O\nWELSH B-MISC\nRESULTS O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nResults O\nof O\nEnglish B-MISC\n, O\nScottish B-MISC\nand O\n\nWelsh B-MISC\nrugby O\nunion O\nmatches O\non O\nSaturday O\n: O\n\nEnglish B-MISC\nNational I-MISC\nLeague I-MISC\none O\n\nHarlequins B-ORG\n75 O\nGloucester B-ORG\n19 O\n\nLondon B-ORG\nIrish I-ORG\n27 O\nBristol B-ORG\n28 O\n\nNorthampton B-ORG\n46 O\nWest B-ORG\nHartlepool I-ORG\n20 O\n\nOrrell B-ORG\n13 O\nBath B-ORG\n56 O\n\nSale B-ORG\n31 O\nWasps B-ORG\n33 O\n\nSaracens B-ORG\n25 O\nLeicester B-ORG\n23 O\n\nWelsh B-MISC\ndivision O\none O\n\nBridgend B-ORG\n13 O\nLlanelli B-ORG\n9 O\n\nDunvant B-ORG\n21 O\nEbbw B-ORG\nVale I-ORG\n10 O\n\nTreorchy B-ORG\n17 O\nNewbridge B-ORG\n23 O\n\nNewport B-ORG\n29 O\nCaerphilly B-ORG\n10 O\n\nSwansea B-ORG\n49 O\nCardiff B-ORG\n23 O\n\nScottish B-MISC\npremier O\nleague O\ndivision O\none O\n\nBoroughmuir B-ORG\n20 O\nHawick B-ORG\n23 O\n\nCurrie B-ORG\n45 O\nHeriot B-ORG\n's I-ORG\nF.P. I-ORG\n5 O\n\nJed-Forest B-ORG\n17 O\nWatsonians B-ORG\n54 O\n\nMelrose B-ORG\n107 O\nStirling B-ORG\nCounty O\n10 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nWALES B-LOC\nBEAT O\nSAN B-LOC\nMARINO I-LOC\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nCARDIFF B-LOC\n1996-08-31 O\n\nWales B-LOC\nbeat O\nSan B-LOC\nMarino I-LOC\n6-0 O\n( O\nhalftime O\n4-0 O\n) O\nin O\na O\nWorld B-MISC\nCup I-MISC\nsoccer O\nEuropean B-MISC\ngroup O\n7 O\nqualifier O\non O\nSaturday O\n. O\n\nScorers O\n: O\nDean B-PER\nSaunders I-PER\n( O\n2nd O\nminute O\n, O\n75th O\n) O\n, O\nMark B-PER\nHughes I-PER\n( O\n25th O\n, O\n54th O\n) O\n, O\nAndy B-PER\nMelville I-PER\n( O\n33rd O\n) O\n, O\nJohn B-PER\nRobinson I-PER\n( O\n45th O\n) O\n. O\n\nAttendance O\n: O\n15,150 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nUKRAINE B-LOC\nBEAT O\nNORTHERN B-LOC\nIRELAND I-LOC\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nBELFAST B-LOC\n1996-08-31 O\n\nUkraine B-LOC\nbeat O\nNorthern B-LOC\nIreland I-LOC\n1-0 O\n( O\nhalftime O\n0-0 O\n) O\nin O\na O\nWorld B-MISC\nCup I-MISC\nsoccer O\nEuropean B-MISC\ngroup O\nnine O\nqualifier O\non O\nSaturday O\n. O\n\nScorer O\n: O\nSergei B-PER\nRebrov I-PER\n( O\n79th O\nminute O\n) O\n\nAttendance O\n: O\n9,358 O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nLYNAGH B-PER\nSEALS O\nVICTORY O\nOVER O\nDWYER B-ORG\nAND O\nLEICESTER B-ORG\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nFormer O\nWallaby B-ORG\ncaptain O\nMichael B-PER\nLynagh I-PER\nbegan O\nhis O\ncareer O\nin O\nEnglish B-MISC\nclub O\nrugby O\nin O\nimpeccable O\nfashion O\non O\nSaturday O\nto O\nfrustrate O\nhis O\nold O\ncoach O\nBob B-PER\nDwyer I-PER\non O\nhis O\nleague O\ncoaching O\ndebut O\nwith O\nLeicester B-LOC\n. O\n\nLynagh B-PER\nkicked O\nfive O\npenalties O\nand O\na O\nconversion O\nfrom O\nhis O\nsix O\nattempts O\nat O\ngoal O\nto O\nsteer O\nhis O\nmulti-national O\nSaracens B-ORG\nside O\nto O\na O\n25-23 O\nhome O\nwin O\nand O\noffer O\nmillionaire O\nbacker O\nNigel B-PER\nWray I-PER\nan O\nearly O\nreturn O\non O\nhis O\nbig O\ninvestment O\nin O\nthe O\nnorth O\nLondon B-LOC\nclub O\n. O\n\nFrench B-MISC\ncentre O\nPhilippe B-PER\nSella I-PER\nalso O\nenjoyed O\na O\ngood O\ngame O\nalongside O\nLynagh B-PER\n, O\nalthough O\nthe O\nhome O\nteam O\nscored O\nonly O\none O\ntry O\nthrough O\nEngland B-LOC\nscrum-half O\nKyran B-PER\nBracken I-PER\n. O\n\nThe O\nnew O\nFrench B-MISC\nconnection O\nat O\nHarlequins B-LOC\nalso O\nmade O\na O\ngood O\nstart O\n, O\nLaurent B-PER\nCabannes I-PER\nand O\nLaurent B-PER\nBenezech I-PER\nscoring O\na O\ntry O\napiece O\nin O\ntheir O\nside O\n's O\n75-19 O\nvictory O\nover O\nGloucester B-ORG\n. O\n\nFormer O\nEngland B-LOC\ncaptain O\nWill B-PER\nCarling I-PER\n, O\nhanded O\nthe O\nkicking O\nduties O\n, O\nfinished O\nwith O\n20 O\npoints O\n. O\n\nWith O\nthe O\nfirst O\nday O\nof O\nthe O\nleague O\nseason O\nbriefly O\nshifting O\nthe O\nspotlight O\naway O\nfrom O\nthe O\ndiscord O\nbetween O\nthe O\nclubs O\nand O\nthe O\nRugby B-ORG\nFootball I-ORG\nUnion I-ORG\n, O\nthere O\nwere O\nalso O\nemphatic O\nvictories O\nfor O\nchampions O\nBath B-ORG\n, O\n56-13 O\nwinners O\nover O\nOrrell B-ORG\n, O\nand O\nNorthampton B-ORG\nand O\nnarrow O\nsuccesses O\nfor O\nWasps B-ORG\nand O\nBristol B-ORG\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSCOTTISH B-MISC\nLEAGUE O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nScottish B-MISC\nleague O\nstandings O\nafter O\n\nSaturday O\n's O\nmatches O\n( O\ntabulated O\n- O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nDivision O\none O\n\nGreenock B-ORG\nMorton I-ORG\n3 O\n2 O\n0 O\n1 O\n5 O\n2 O\n6 O\n\nDundee B-ORG\n3 O\n1 O\n2 O\n0 O\n3 O\n2 O\n5 O\n\nSt B-ORG\nJohnstone I-ORG\n2 O\n1 O\n1 O\n0 O\n3 O\n0 O\n4 O\n\nSt B-ORG\nMirren I-ORG\n3 O\n1 O\n1 O\n1 O\n5 O\n4 O\n4 O\n\nAirdrieonians B-ORG\n2 O\n1 O\n1 O\n0 O\n1 O\n0 O\n4 O\n\nFalkirk B-ORG\n3 O\n1 O\n1 O\n1 O\n1 O\n1 O\n4 O\n\nClydebank B-ORG\n2 O\n1 O\n0 O\n1 O\n1 O\n3 O\n3 O\n\nPartick B-ORG\n3 O\n0 O\n2 O\n1 O\n1 O\n2 O\n2 O\n\nStirling B-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n3 O\n1 O\n\nEast B-ORG\nFife I-ORG\n2 O\n0 O\n1 O\n1 O\n0 O\n4 O\n1 O\n\nDivision O\ntwo O\n\nLivingston B-ORG\n3 O\n3 O\n0 O\n0 O\n6 O\n2 O\n9 O\n\nQueen B-ORG\nof I-ORG\nSouth I-ORG\n3 O\n2 O\n0 O\n1 O\n5 O\n4 O\n6 O\n\nAyr B-ORG\n3 O\n1 O\n2 O\n0 O\n8 O\n2 O\n5 O\n\nStenhousemuir B-ORG\n3 O\n1 O\n1 O\n1 O\n6 O\n1 O\n4 O\n\nHamilton B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n2 O\n4 O\n\nStranraer B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n3 O\n4 O\n\nBrechin B-ORG\n3 O\n0 O\n3 O\n0 O\n2 O\n2 O\n3 O\n\nClyde B-ORG\n3 O\n1 O\n0 O\n2 O\n2 O\n5 O\n3 O\n\nDumbarton B-ORG\n3 O\n0 O\n2 O\n1 O\n3 O\n4 O\n2 O\n\nBerwick B-ORG\n3 O\n0 O\n0 O\n3 O\n1 O\n14 O\n0 O\n\nDivision O\nthree O\n\nAlbion B-ORG\n3 O\n3 O\n0 O\n0 O\n5 O\n0 O\n9 O\n\nForfar B-ORG\n3 O\n2 O\n0 O\n1 O\n7 O\n4 O\n6 O\n\nCowdenbeath B-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n3 O\n6 O\n\nArbroath B-ORG\n3 O\n1 O\n2 O\n0 O\n4 O\n2 O\n5 O\n\nAlloa B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n3 O\n4 O\n\nQueen B-ORG\n's I-ORG\nPark I-ORG\n3 O\n1 O\n1 O\n1 O\n6 O\n8 O\n4 O\n\nMontrose B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n4 O\n3 O\n\nInverness B-ORG\nThistle I-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n6 O\n3 O\n\nEast B-ORG\nStirling I-ORG\n3 O\n0 O\n2 O\n1 O\n3 O\n4 O\n2 O\n\nRoss B-ORG\nCounty I-ORG\n3 O\n0 O\n0 O\n3 O\n3 O\n7 O\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nLEAGUE O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nEnglish B-MISC\nsoccer O\nleague O\nstandings O\n\nafter O\nSaturday O\n's O\nmatches O\n( O\ntabulated O\n- O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\n\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nDivision O\none O\n\nStoke B-ORG\n4 O\n3 O\n1 O\n0 O\n7 O\n4 O\n10 O\n\nBarnsley B-ORG\n3 O\n3 O\n0 O\n0 O\n8 O\n2 O\n9 O\n\nNorwich B-ORG\n4 O\n3 O\n0 O\n1 O\n5 O\n3 O\n9 O\n\nTranmere B-ORG\n4 O\n2 O\n1 O\n1 O\n6 O\n4 O\n7 O\n\nBolton B-ORG\n3 O\n2 O\n1 O\n0 O\n5 O\n2 O\n7 O\n\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\n3 O\n2 O\n1 O\n0 O\n5 O\n3 O\n7 O\n\nWolverhampton B-ORG\n4 O\n2 O\n1 O\n1 O\n5 O\n3 O\n7 O\n\nSwindon B-ORG\n4 O\n2 O\n1 O\n1 O\n5 O\n4 O\n7 O\n\nBradford B-ORG\n4 O\n2 O\n0 O\n2 O\n4 O\n3 O\n6 O\n\nPortsmouth B-ORG\n4 O\n2 O\n0 O\n2 O\n4 O\n5 O\n6 O\n\nIpswich B-ORG\n4 O\n1 O\n2 O\n1 O\n9 O\n7 O\n5 O\n\nCrystal B-ORG\nPalace I-ORG\n4 O\n1 O\n2 O\n1 O\n4 O\n3 O\n5 O\n\nPort B-ORG\nVale I-ORG\n4 O\n1 O\n2 O\n1 O\n4 O\n4 O\n5 O\n\nBirmingham B-ORG\n2 O\n1 O\n1 O\n0 O\n5 O\n4 O\n4 O\n\nReading B-ORG\n4 O\n1 O\n1 O\n2 O\n5 O\n10 O\n4 O\n\nHuddersfield B-ORG\n3 O\n1 O\n1 O\n1 O\n4 O\n4 O\n4 O\n\nOxford B-ORG\n4 O\n1 O\n0 O\n3 O\n6 O\n5 O\n3 O\n\nManchester B-ORG\nCity I-ORG\n3 O\n1 O\n0 O\n2 O\n2 O\n3 O\n3 O\n\nWest B-ORG\nBromwich I-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n3 O\n2 O\n\nOldham B-ORG\n4 O\n0 O\n1 O\n3 O\n5 O\n9 O\n1 O\n\nSheffield B-ORG\nUnited I-ORG\n2 O\n0 O\n1 O\n1 O\n4 O\n5 O\n1 O\n\nGrimsby B-ORG\n4 O\n0 O\n1 O\n3 O\n4 O\n8 O\n1 O\n\nSouthend B-ORG\n4 O\n0 O\n1 O\n3 O\n2 O\n10 O\n1 O\n\nCharlton B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n3 O\n1 O\n\nDivision O\ntwo O\n\nPlymouth B-ORG\n4 O\n3 O\n1 O\n0 O\n10 O\n6 O\n10 O\n\nBrentford B-ORG\n4 O\n3 O\n1 O\n0 O\n9 O\n3 O\n10 O\n\nBury B-ORG\n4 O\n3 O\n1 O\n0 O\n8 O\n2 O\n10 O\n\nChesterfield B-ORG\n4 O\n3 O\n0 O\n1 O\n4 O\n2 O\n9 O\n\nMillwall B-ORG\n4 O\n2 O\n1 O\n1 O\n7 O\n5 O\n7 O\n\nShrewsbury B-ORG\n4 O\n2 O\n1 O\n1 O\n6 O\n6 O\n7 O\n\nBlackpool B-ORG\n4 O\n2 O\n1 O\n1 O\n3 O\n2 O\n7 O\n\nYork B-ORG\n4 O\n2 O\n0 O\n2 O\n6 O\n6 O\n6 O\n\nBurnley B-ORG\n4 O\n2 O\n0 O\n2 O\n6 O\n7 O\n6 O\n\nBournemouth B-ORG\n4 O\n2 O\n0 O\n2 O\n5 O\n5 O\n6 O\n\nWatford B-ORG\n4 O\n2 O\n0 O\n2 O\n4 O\n5 O\n6 O\n\nBristol B-ORG\nRovers I-ORG\n3 O\n1 O\n2 O\n0 O\n2 O\n1 O\n5 O\n\nPeterborough B-ORG\n3 O\n1 O\n1 O\n1 O\n4 O\n4 O\n4 O\n\nPreston B-ORG\n4 O\n1 O\n1 O\n2 O\n4 O\n5 O\n4 O\n\nCrewe B-ORG\n4 O\n1 O\n1 O\n2 O\n4 O\n6 O\n4 O\n\nGillingham B-ORG\n4 O\n1 O\n1 O\n2 O\n4 O\n6 O\n4 O\n\nNotts B-ORG\nCounty I-ORG\n3 O\n1 O\n1 O\n1 O\n2 O\n2 O\n4 O\n\nBristol B-ORG\nCity I-ORG\n4 O\n1 O\n0 O\n3 O\n7 O\n8 O\n3 O\n\nLuton B-ORG\n4 O\n1 O\n0 O\n3 O\n4 O\n10 O\n3 O\n\nWycombe B-ORG\n4 O\n0 O\n3 O\n1 O\n2 O\n3 O\n3 O\n\nWrexham B-ORG\n2 O\n0 O\n2 O\n0 O\n5 O\n5 O\n2 O\n\nStockport B-ORG\n4 O\n0 O\n2 O\n2 O\n1 O\n3 O\n2 O\n\nRotherham B-ORG\n4 O\n0 O\n1 O\n3 O\n3 O\n6 O\n1 O\n\nWalsall B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n4 O\n1 O\n\nDivision O\nthree O\n\nWigan B-ORG\n4 O\n3 O\n1 O\n0 O\n9 O\n4 O\n10 O\n\nFulham B-ORG\n4 O\n3 O\n0 O\n1 O\n5 O\n3 O\n9 O\n\nHull B-ORG\n4 O\n2 O\n2 O\n0 O\n4 O\n2 O\n8 O\n\nHartlepool B-ORG\n4 O\n2 O\n1 O\n1 O\n6 O\n5 O\n7 O\n\nTorquay B-ORG\n4 O\n2 O\n1 O\n1 O\n5 O\n3 O\n7 O\n\nCardiff B-ORG\n4 O\n2 O\n1 O\n1 O\n3 O\n2 O\n7 O\n\nScunthorpe B-ORG\n4 O\n2 O\n1 O\n1 O\n3 O\n3 O\n7 O\n\nCarlisle B-ORG\n4 O\n2 O\n1 O\n1 O\n2 O\n1 O\n7 O\n\nScarborough B-ORG\n4 O\n1 O\n3 O\n0 O\n5 O\n3 O\n6 O\n\nNorthampton B-ORG\n4 O\n1 O\n2 O\n1 O\n6 O\n4 O\n5 O\n\nLincoln B-ORG\n4 O\n1 O\n2 O\n1 O\n5 O\n5 O\n5 O\n\nBarnet B-ORG\n4 O\n1 O\n2 O\n1 O\n4 O\n2 O\n5 O\n\nExeter B-ORG\n4 O\n1 O\n2 O\n1 O\n4 O\n5 O\n5 O\n\nCambridge B-ORG\nUnited I-ORG\n4 O\n1 O\n2 O\n1 O\n3 O\n4 O\n5 O\n\nDarlington B-ORG\n4 O\n1 O\n1 O\n2 O\n9 O\n8 O\n4 O\n\nChester B-ORG\n4 O\n1 O\n1 O\n2 O\n6 O\n7 O\n4 O\n\nDoncaster B-ORG\n4 O\n1 O\n1 O\n2 O\n4 O\n5 O\n4 O\n\nLeyton B-ORG\nOrient I-ORG\n4 O\n1 O\n1 O\n2 O\n3 O\n3 O\n4 O\n\nBrighton B-ORG\n4 O\n1 O\n1 O\n2 O\n3 O\n6 O\n4 O\n\nHereford B-ORG\n4 O\n1 O\n1 O\n2 O\n2 O\n3 O\n4 O\n\nSwansea B-ORG\n4 O\n1 O\n0 O\n3 O\n4 O\n9 O\n3 O\n\nColchester B-ORG\n4 O\n0 O\n3 O\n1 O\n2 O\n4 O\n3 O\n\nRochdale B-ORG\n4 O\n0 O\n2 O\n2 O\n2 O\n4 O\n2 O\n\nMansfield B-ORG\n4 O\n0 O\n2 O\n2 O\n2 O\n6 O\n2 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSCOTTISH B-MISC\nLEAGUE O\nRESULTS O\n. O\n\nGLASGOW B-LOC\n1996-08-31 O\n\nResults O\nof O\nScottish B-MISC\nleague O\n\nmatches O\non O\nSaturday O\n: O\n\nDivision O\none O\n\nGreenock B-ORG\nMorton I-ORG\n1 O\nFalkirk B-ORG\n0 O\n\nPartick B-ORG\n1 O\nSt B-ORG\nMirren I-ORG\n1 O\n\nStirling B-ORG\n1 O\nDundee B-ORG\n1 O\n\nPostponed O\n: O\nEast B-ORG\nFife I-ORG\nv O\nClydebank B-ORG\n, O\nSt B-ORG\nJohnstone I-ORG\nv O\n\nAirdrieonians B-ORG\n. O\n\nDivision O\ntwo O\n\nAyr B-ORG\n6 O\nBerwick B-ORG\n0 O\n\nClyde B-ORG\n0 O\nQueen B-ORG\nof I-ORG\nSouth I-ORG\n2 O\n\nDumbarton B-ORG\n1 O\nBrechin B-ORG\n1 O\n\nLivingston B-ORG\n1 O\nHamilton B-ORG\n0 O\n\nStenhousemuir B-ORG\n0 O\nStranraer B-ORG\n1 O\n\nDivision O\nthree O\n\nAlbion B-ORG\n2 O\nCowdenbeath B-ORG\n0 O\n\nArbroath B-ORG\n0 O\nEast B-ORG\nStirling I-ORG\n0 O\n\nInverness B-ORG\nThistle I-ORG\n1 O\nAlloa B-ORG\n0 O\n\nMontrose B-ORG\n2 O\nRoss B-ORG\nCounty I-ORG\n1 O\n\nQueen B-ORG\n's I-ORG\nPark I-ORG\n1 O\nForfar B-ORG\n4 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nLEAGUE O\nRESULTS O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nResults O\nof O\nEnglish B-MISC\nsoccer O\nmatches O\n\non O\nSaturday O\n: O\n\nDivision O\none O\n\nBradford B-ORG\n1 O\nTranmere B-ORG\n0 O\n\nGrimsby B-ORG\n0 O\nPortsmouth B-ORG\n1 O\n\nHuddersfield B-ORG\n1 O\nCrystal B-ORG\nPalace I-ORG\n1 O\n\nNorwich B-ORG\n1 O\nWolverhampton B-ORG\n0 O\n\nOldham B-ORG\n3 O\nIpswich B-ORG\n3 O\n\nPort B-ORG\nVale I-ORG\n2 O\nOxford B-ORG\n0 O\n\nReading B-ORG\n2 O\nStoke B-ORG\n2 O\n\nSouthend B-ORG\n1 O\nSwindon B-ORG\n3 O\n\nPostponed O\n: O\nBirmingham B-ORG\nv O\nBarnsley B-ORG\n, O\nManchester B-ORG\nCity I-ORG\nv O\nCharlton B-ORG\n\nPlaying O\nSunday O\n: O\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\nv O\nBolton B-ORG\n\nDivision O\ntwo O\n\nBlackpool B-ORG\n0 O\nWycombe B-ORG\n0 O\n\nBournemouth B-ORG\n1 O\nPeterborough B-ORG\n2 O\n\nBristol B-ORG\nRovers I-ORG\n1 O\nStockport B-ORG\n1 O\n\nBury B-ORG\n4 O\nBristol B-ORG\nCity I-ORG\n0 O\n\nCrewe B-ORG\n0 O\nWatford B-ORG\n2 O\n\nGillingham B-ORG\n0 O\nChesterfield B-ORG\n1 O\n\nLuton B-ORG\n1 O\nRotherham B-ORG\n0 O\n\nMillwall B-ORG\n2 O\nBurnley B-ORG\n1 O\n\nNotts B-ORG\nCounty I-ORG\n0 O\nYork B-ORG\n1 O\n\nShrewsbury B-ORG\n0 O\nBrentford3 B-ORG\n\nPostponed O\n: O\nWalsall B-ORG\nv O\nWrexham B-ORG\n\nDivision O\nthree O\n\nBrighton B-ORG\n1 O\nScunthorpe B-ORG\n1 O\n\nCambridge B-ORG\nUnited I-ORG\n0 O\nCardiff B-ORG\n2 O\n\nColchester B-ORG\n1 O\nHereford B-ORG\n1 O\n\nDoncaster B-ORG\n3 O\nDarlington B-ORG\n2 O\n\nFulham B-ORG\n1 O\nCarlisle B-ORG\n0 O\n\nHull B-ORG\n0 O\nBarnet B-ORG\n0 O\n\nLeyton B-ORG\nOrient I-ORG\n2 O\nHartlepool B-ORG\n0 O\n\nMansfield B-ORG\n0 O\nRochdale B-ORG\n0 O\n\nScarborough B-ORG\n1 O\nNorthampton B-ORG\n1 O\n\nTorquay B-ORG\n2 O\nExeter B-ORG\n0 O\n\nWigan B-ORG\n4 O\nChester B-ORG\n2 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLISH B-MISC\nCOUNTY I-MISC\nCHAMPIONSHIP I-MISC\nSCORES O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nResults O\nand O\nclose O\nscores O\nof O\nfour-day O\nEnglish B-MISC\ncounty O\nchampionship O\nmatches O\non O\nSaturday O\n: O\n\nAt O\nPortsmouth B-LOC\n: O\nMiddlesex B-ORG\nbeat O\nHampshire B-ORG\nby O\n188 O\nruns O\n. O\n\nMiddlesex B-ORG\n199 O\nand O\n426 O\n, O\nHampshire B-ORG\n232 O\nand O\n205 O\n( O\nA. B-PER\nFraser I-PER\n5-79 O\n, O\nP. B-PER\nTufnell I-PER\n4-39 O\n) O\n. O\n\nMiddlesex B-ORG\n20 O\npoints O\n, O\nHampshire B-ORG\n5 O\n. O\n\nAt O\nChester-le-Street B-LOC\n: O\nGlamorgan B-ORG\nbeat O\nDurham B-ORG\nby O\n141 O\nruns O\n. O\n\nGlamorgan B-ORG\n259 O\nand O\n207 O\n, O\nDurham B-ORG\n114 O\nand O\n211 O\n. O\n\nGlamorgan B-ORG\n22 O\npoints O\n, O\nDurham B-ORG\n4 O\n. O\n\nAt O\nChesterfield B-LOC\n: O\nDerbyshire B-ORG\nbeat O\nWorcestershire B-ORG\nby O\nnine O\nwickets O\n. O\n\nWorcestershire B-ORG\n238 O\nand O\n303 O\n( O\nK. B-PER\nSpiring I-PER\n130 O\nnot O\nout O\n, O\nS. B-PER\nRhodes I-PER\n57 O\n; O\nP. B-PER\nDeFreitas I-PER\n4-70 O\n) O\n, O\nDerbyshire B-ORG\n471 O\nand O\n71-1 O\n. O\n\nDerbyshire B-ORG\n24 O\npoints O\n, O\nWorcestershire B-ORG\n5 O\n. O\n\nAt O\nThe B-LOC\nOval I-LOC\n( O\nLondon B-LOC\n) O\n: O\nSurrey B-ORG\nbeat O\nWarwickshire B-ORG\nby O\nan O\ninnings O\nand O\n164 O\nruns O\n. O\n\nWarwickshire B-ORG\n195 O\nand O\n109 O\n( O\nJ. B-PER\nBenjamin I-PER\n4-17 O\n, O\nM. B-PER\nBicknell I-PER\n4-38 O\n) O\n, O\nSurrey B-ORG\n468 O\n( O\nC. B-PER\nLewis I-PER\n94 O\n, O\nM. B-PER\nButcher I-PER\n70 O\n, O\nG. B-PER\nKersey I-PER\n63 O\n, O\nJ. B-PER\nRatcliffe I-PER\n63 O\n, O\nD. B-PER\nBicknell I-PER\n55 O\n) O\n. O\n\nSurrey B-ORG\n24 O\npoints O\n, O\nWarwickshire B-ORG\n2 O\n. O\n\nAt O\nHeadingley B-LOC\n( O\nLeeds B-LOC\n) O\n: O\nYorkshire B-ORG\n290 O\nand O\n329 O\n( O\nR. B-PER\nKettleborough I-PER\n108 O\n, O\nG. B-PER\nHamilton I-PER\n61 O\n; O\nP. B-PER\nSuch I-PER\n8-118 O\n) O\n, O\nEssex B-ORG\n372 O\nand O\n100-5 O\n. O\n\nAt O\nHove B-LOC\n: O\nSussex B-ORG\n363 O\nand O\n144 O\n, O\nLancashire B-ORG\n218 O\nand O\n53-0 O\n. O\n\nAt O\nTunbridge B-LOC\nWells I-LOC\n: O\nNottinghamshire B-ORG\n214 O\nand O\n167-6 O\n( O\nC. B-PER\nTolley I-PER\n64 O\nnot O\nout O\n) O\n, O\nKent B-ORG\n244 O\n( O\nC. B-PER\nHooper I-PER\n58 O\n; O\nC. B-PER\nTolley I-PER\n4-68 O\n, O\nK. B-PER\nEvans I-PER\n4-71 O\n) O\n\nAt O\nBristol B-LOC\n: O\nGloucestershire B-ORG\n183 O\nand O\n249 O\n( O\nJ. B-PER\nRussell I-PER\n75 O\n) O\n, O\nNorthamptonshire B-ORG\n190 O\nand O\n218-9 O\n. O\n\n-DOCSTART- O\n\nMOTOR O\nRACING O\n- O\nLEADING O\nQUALIFIERS O\nFOR O\nVANCOUVER B-LOC\nINDYCAR B-MISC\nRACE O\n. O\n\nVANCOUVER B-LOC\n1996-08-31 O\n\nTop O\nten O\ndrivers O\nin O\ngrid O\nfor O\n\nSunday O\n's O\nVancouver B-LOC\nIndyCar B-MISC\nrace O\nafter O\nfinal O\nqualifying O\non O\n\nSaturday O\n( O\ntabulate O\nby O\ndriver O\n, O\ncountry O\n, O\nchassis O\n, O\nmotor O\nand O\nlap O\n\ntimes O\nin O\nseconds O\n) O\n: O\n\n1. O\nAlex B-PER\nZanardi I-PER\n( O\nItaly B-LOC\n) O\n, O\nReynard B-ORG\nHonda I-ORG\n, O\n53.980 O\n( O\n113.576 O\n\nmph O\n/ O\n182.778 O\nkph O\n) O\n\n2. O\nMichael B-PER\nAndretti I-PER\n( O\nU.S. B-LOC\n) O\n, O\nLola B-ORG\nFord I-ORG\nCosworth I-ORG\n, O\n54.483 O\n\n3. O\nBobby B-PER\nRahal I-PER\n( O\nU.S. B-LOC\n) O\n, O\nReynard B-ORG\nMercedes-Benz I-ORG\n, O\n54.507 O\n\n4. O\nBryan B-PER\nHerta I-PER\n( O\nU.S. B-LOC\n) O\n, O\nReynard B-ORG\nMercedes-Benz I-ORG\n, O\n54.578 O\n\n5. O\nJimmy B-PER\nVasser I-PER\n( O\nU.S. B-LOC\n) O\n, O\nReynard B-ORG\nHonda I-ORG\n, O\n54.617 O\n\n6. O\nPaul B-PER\nTracy I-PER\n( O\nCanada B-LOC\n) O\n, O\nPenske B-ORG\nMercedes-Benz I-ORG\n, O\n54.620 O\n\n7. O\nAl B-PER\nUnser I-PER\nJr O\n( O\nU.S. B-LOC\n) O\n, O\nPenske B-ORG\nMercedes-Benz I-ORG\n, O\n54.683 O\n\n8. O\nAndre B-PER\nRibeiro I-PER\n( O\nBrazil B-LOC\n) O\n, O\nLola B-ORG\nHonda I-ORG\n, O\n54.750 O\n\n9. O\nMauricio B-PER\nGugelmin I-PER\n( O\nBrazil B-LOC\n) O\n, O\nReynard B-ORG\nFord I-ORG\nCosworth I-ORG\n, O\n54.762 O\n\n10. O\nGil B-PER\nde I-PER\nFerran I-PER\n( O\nBrazil B-LOC\n) O\n, O\nReynard B-ORG\nHonda I-ORG\n, O\n54.774 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nCANADA B-LOC\nBEAT O\nPANAMA B-LOC\n3-1 O\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nEDMONTON B-LOC\n1996-08-31 O\n\nCanada B-LOC\nbeat O\nPanama B-LOC\n3-1 O\n( O\nhalftime O\n2-0 O\n) O\nin O\ntheir O\nCONCACAF B-ORG\nsemifinal O\nphase O\nqualifying O\nmatch O\nfor O\nthe O\n1998 O\nWorld B-MISC\nCup I-MISC\non O\nFriday O\n. O\n\nScorers O\n: O\n\nCanada B-LOC\n- O\nAunger B-PER\n( O\n41st O\nmin O\n, O\npen O\n) O\n, O\nPaul B-PER\nPeschisolido I-PER\n( O\n42nd O\n) O\n, O\nCarlo B-PER\nCorrazin I-PER\n( O\n87th O\n) O\n\nPanama B-LOC\n- O\nJorge B-PER\nLuis I-PER\nDely I-PER\nValdes I-PER\n( O\n50th O\n) O\n\nAttendance O\n: O\n9,402 O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nSPRINGBOKS B-ORG\nFINALLY O\nBREAK O\nALL B-ORG\nBLACK I-ORG\nSPELL O\n. O\n\nAndy B-PER\nColquhoun I-PER\n\nJOHANNESBURG B-LOC\n1996-08-31 O\n\nSouth B-LOC\nAfrica I-LOC\nmanaged O\nto O\navoid O\na O\nfifth O\nsuccessive O\ndefeat O\nin O\n1996 O\nat O\nthe O\nhands O\nof O\nthe O\nAll B-ORG\nBlacks I-ORG\nwith O\nan O\nemphatic O\n32-22 O\nvictory O\nin O\nfront O\nof O\nan O\necstatic O\nEllis B-LOC\nPark I-LOC\ncrowd O\non O\nSaturday O\n. O\n\nThey O\nscored O\nthree O\ntries O\nin O\nrecording O\ntheir O\nhighest O\ntotal O\nagainst O\nNew B-LOC\nZealand I-LOC\n, O\nsalvaging O\nsome O\npride O\nin O\na O\nseason O\nin O\nwhich O\nthe O\nworld O\nchampions O\nhave O\nlost O\nfive O\nout O\nof O\neight O\ntests O\n. O\n\nIt O\nalso O\nended O\na O\nrun O\nof O\nnine O\nsuccessive O\nvictories O\nthis O\nyear O\nfor O\nNew B-LOC\nZealand I-LOC\nbut O\narrived O\ntoo O\nlate O\nto O\nprevent O\na O\n2-1 O\nseries O\ndefeat O\nand O\nan O\nhistoric O\nfirst O\nAll B-ORG\nBlack I-ORG\nseries O\ntriumph O\non O\nSouth B-MISC\nAfrican I-MISC\nsoil O\n. O\n\nSpringbok B-ORG\nscrum-half O\nJoost B-PER\nvan I-PER\nder I-PER\nWesthuizen I-PER\nwas O\nhis O\nside O\n's O\ninspiration O\n, O\nscoring O\ntheir O\nopening O\ntry O\nand O\nmaking O\nthe O\nthird O\nfor O\nflanker O\nAndre B-PER\nVenter I-PER\nfrom O\na O\nquickly O\ntaken O\npenalty O\nto O\ngive O\nhis O\nside O\na O\n29-8 O\nlead O\nafter O\n54 O\nminutes O\n. O\n\nFullback O\nAndre B-PER\nJoubert I-PER\nscored O\nthe O\nother O\n, O\nscorching O\nin O\nfrom O\n40 O\nmetres O\nat O\nthe O\nstart O\nof O\nthe O\nsecond O\nhalf O\nto O\nadd O\nto O\nhis O\nthree O\nlong-range O\npenalties O\n. O\n\nThe O\nAll B-ORG\nBlacks I-ORG\nsalvaged O\nsome O\npride O\nby O\nscoring O\ntwo O\ntries O\nfrom O\ncentre O\nWalter B-PER\nLittle I-PER\nand O\nscrum-half O\nJustin B-PER\nMarshall I-PER\nin O\nthe O\nfinal O\nfive O\nminutes O\nto O\nclose O\na O\ngap O\nwhich O\nat O\none O\npoint O\nstood O\nat O\n24 O\npoints O\n. O\n\nBut O\nthey O\ngenerally O\nendured O\nan O\noff-day O\n, O\nhighlighted O\nby O\nrecalled O\nfly-half O\nAndrew B-PER\nMehrtens I-PER\nwho O\nmissed O\nfive O\nout O\nof O\neight O\nkicks O\nat O\ngoal O\n. O\n\nRecalled O\nfly-half O\nHenry B-PER\nHoniball I-PER\nkicked O\nthe O\nSpringboks B-ORG\ninto O\na O\n6-0 O\nlead O\nafter O\n10 O\nminutes O\nonly O\nto O\nsee O\nAndrew B-PER\nMehrtens I-PER\nlaunch O\na O\npenalty O\nfrom O\neight O\nmetres O\ninside O\nhis O\nown O\nhalf O\nto O\nnarrow O\nthe O\ngap O\n. O\n\nMehrtens B-PER\nmissed O\nthree O\nfurther O\npenalties O\nand O\na O\nconversion O\nin O\nthe O\nfirst O\n40 O\nminutes O\nwhich O\ncould O\nhave O\nput O\nhis O\nside O\nahead O\n, O\nbut O\nit O\nwas O\nthe O\nSpringboks B-ORG\nwho O\nlooked O\nthe O\nmore O\ndangerous O\n. O\n\nTheir O\npromise O\nwas O\nrealised O\nwhen O\nJoubert B-PER\nmade O\na O\n40-metre O\nbreak O\nin O\nthe O\n25th O\nminute O\nand O\n, O\nalthough O\nwinger O\nPieter B-PER\nHendriks I-PER\nappeared O\nto O\nknock O\non O\nJoubert B-PER\n's O\nreverse O\npass O\n, O\nWelsh B-MISC\nreferee O\nDerek B-PER\nBevan I-PER\nallowed O\nVan B-PER\nder I-PER\nWesthuizen I-PER\nto O\npick O\nup O\nand O\nscore O\nunder O\nthe O\nposts O\n. O\n\nHoniball B-PER\nconverted O\nand O\nJoubert B-PER\nkicked O\na O\npenalty O\nbefore O\nAll B-ORG\nBlack I-ORG\nhooker O\nSean B-PER\nFitzpatrick I-PER\nscored O\na O\ntry O\nfrom O\nclose O\nrange O\non O\nthe O\nstroke O\nof O\nhalf-time O\nto O\nnarrow O\nthe O\nlead O\nto O\n16-8 O\nand O\nhint O\nat O\na O\ncomeback O\n. O\n\nInstead O\nJoubert B-PER\nkicked O\nanother O\nlong O\npenalty O\nand O\nthen O\nraced O\naround O\nthe O\noutside O\nof O\nthe O\ndefence O\nto O\nscore O\nthe O\nSpringboks B-ORG\n' O\nsecond O\ntry O\n. O\n\nA O\nquick O\npenalty O\nfrom O\nVan B-PER\nder I-PER\nWesthuizen I-PER\nfive O\nmetres O\nfrom O\nthe O\nAll B-ORG\nBlack I-ORG\nline O\nset O\nup O\nthe O\nthird O\ntry O\nfor O\nVenter B-PER\nfive O\nminutes O\nlater O\nand O\nwhen O\nJoubert B-PER\nkicked O\nhis O\nthird O\npenalty O\nthe O\nSpringboks B-ORG\nheld O\nan O\nunassailable O\n32-8 O\nlead O\ngoing O\ninto O\nthe O\nlast O\nquarter O\n. O\n\nWhen O\nthe O\nAll B-ORG\nBlacks I-ORG\ndid O\nbreak O\nthrough O\n, O\nit O\nwas O\ntoo O\nlate O\n. O\n\nCentre O\nWalter B-PER\nLittle I-PER\nfollowed O\nup O\nMehrtens B-PER\n' O\nkick O\nto O\nscore O\nunder O\nthe O\nposts O\nand O\nscrum-half O\nJustin B-PER\nMarshall I-PER\nforced O\nhimself O\nover O\nfrom O\na O\nruck O\nclose O\nto O\nthe O\nline O\nin O\ninjury-time O\nto O\ngive O\nthem O\nsome O\nconsolation O\n. O\n\nSouth B-LOC\nAfrica I-LOC\n- O\n15 O\n- O\nAndre B-PER\nJoubert I-PER\n, O\n14 O\n- O\nJustin B-PER\nSwart I-PER\n, O\n13 O\n- O\nJapie B-PER\nMulder I-PER\n( O\nJoel B-PER\nStransky I-PER\n, O\n48 O\nmins O\n) O\n12 O\n- O\nDanie B-PER\nvan I-PER\nSchalkwyk I-PER\n, O\n11 O\n- O\nPieter B-PER\nHendriks I-PER\n; O\n10 O\n- O\nHenry B-PER\nHoniball I-PER\n, O\n9 O\n- O\nJoost B-PER\nvan I-PER\nder I-PER\nWesthuizen I-PER\n; O\n8 O\n- O\nGary B-PER\nTeichmann I-PER\n( O\ncaptain O\n) O\n, O\n7 O\n- O\nAndre B-PER\nVenter I-PER\n( O\nWayne B-PER\nFyvie I-PER\n, O\n75 O\n) O\n, O\n6 O\n- O\nRuben B-PER\nKruge I-PER\n, O\n5 O\n- O\nMark B-PER\nAndrews I-PER\n( O\nFritz B-PER\nvan I-PER\nHeerden I-PER\n, O\n39 O\n) O\n, O\n4 O\n- O\nKobus B-PER\nWiese I-PER\n, O\n3 O\n- O\nMarius B-PER\nHurter I-PER\n, O\n2 O\n- O\nJames B-PER\nDalton I-PER\n, O\n1 O\n- O\nDawie B-PER\nTheron I-PER\n( O\nGarry B-PER\nPagel I-PER\n, O\n66 O\n) O\n. O\n\nNew B-LOC\nZealand I-LOC\n- O\n15 O\n- O\nChristian B-PER\nCullen I-PER\n( O\nAlama B-PER\nIeremia I-PER\n, O\n70 O\n) O\n, O\n14 O\n- O\nJeff B-PER\nWilson I-PER\n, O\n13 O\n- O\nWalter B-PER\nLittle I-PER\n, O\n12 O\n- O\nFrank B-PER\nBunce I-PER\n, O\n11 O\n- O\nGlen B-PER\nOsborne I-PER\n; O\n10 O\n- O\nAndrew B-PER\nMehrtens I-PER\n, O\n9 O\n- O\nJustin B-PER\nMarshall I-PER\n; O\n8 O\n- O\nZinzan B-PER\nBrooke I-PER\n, O\n7 O\n- O\nJosh B-PER\nKronfeld I-PER\n, O\n6 O\n- O\nMichael B-PER\nJones I-PER\n( O\nGlenn B-PER\nTaylor I-PER\n, O\n53 O\n) O\n, O\n5 O\n- O\nRobin B-PER\nBrooke I-PER\n, O\n4 O\n- O\nIan B-PER\nJones I-PER\n, O\n3 O\n- O\nOlo B-PER\nBrown I-PER\n, O\n2 O\n- O\nSean B-PER\nFitzpatrick I-PER\n( O\ncaptain O\n) O\n, O\n1 O\n- O\nCraig B-PER\nDowd I-PER\n. O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nSOUTH B-LOC\nAFRICA I-LOC\nBEAT O\nALL B-ORG\nBLACKS I-ORG\n32-22 O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-31 O\n\nSouth B-LOC\nAfrica I-LOC\nbeat O\nNew B-LOC\nZealand I-LOC\n32-22 O\n( O\nhaltime O\n16-8 O\n) O\nin O\nthe O\nfinal O\ntest O\nmatch O\nof O\ntheir O\nthree-test O\nseries O\nat O\nEllis B-LOC\nPark I-LOC\non O\nSaturday O\n. O\n\nScorers O\n: O\n\nSouth B-LOC\nAfrica I-LOC\n- O\nTries O\n: O\nJoost B-PER\nvan I-PER\nder I-PER\nWesthuizen I-PER\n( O\n2 O\n) O\n, O\nAndre B-PER\nJoubert I-PER\n. O\n\nConversion O\n: O\nHenry B-PER\nHoniball I-PER\n. O\n\nPenalties O\n: O\nHoniball B-PER\n( O\n2 O\n) O\n, O\nJoubert B-PER\n( O\n3 O\n) O\n. O\n\nNew B-LOC\nZealand I-LOC\n- O\nTries O\n: O\nSean B-PER\nFitzpatrick I-PER\n, O\nWalter B-PER\nLittle I-PER\n, O\nJustin B-PER\nMarshall I-PER\n. O\n\nConversions O\n: O\nAndrew B-PER\nMehrtens I-PER\n( O\n2 O\n) O\n. O\n\nPenalties O\n: O\nMehrtens B-PER\n. O\n\nNew B-LOC\nZealand I-LOC\nwin O\ntest O\nseries O\n2-1 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nMAURITANIA B-LOC\nDISSOLVES O\nNATIONAL O\nTEAM O\nAFTER O\nCUP B-MISC\nEXIT O\n. O\n\nNOUAKCHOTT B-LOC\n1996-08-31 O\n\nMauritania B-LOC\n's O\nsoccer O\nfederation O\ndissolved O\nthe O\nnational O\nteam O\nand O\nsuspended O\nthis O\nseason O\n's O\ndomestic O\nchampionship O\non O\nSaturday O\nin O\nthe O\nwake O\nof O\nthe O\ncountry O\n's O\nfailure O\nto O\nqualify O\nfor O\nthe O\nAfrican B-MISC\nNations I-MISC\n' I-MISC\nCup I-MISC\n. O\n\n\" O\nSince O\nMauritania B-LOC\nhas O\nbeen O\neliminated O\non O\nall O\nfronts O\nand O\nthe O\nnext O\ncommitments O\nare O\nnot O\nfor O\nanother O\ntwo O\nyears O\n, O\nwe O\nhave O\nreason O\nto O\ntake O\na O\nbreak O\n, O\n\" O\nfederation O\npresident O\nMohamed B-PER\nLemine I-PER\nCheiguer I-PER\nsaid O\n. O\n\nThe O\nNorth B-MISC\nAfricans I-MISC\nwere O\nheld O\nto O\na O\ngoalless O\ndraw O\nby O\nBenin B-LOC\non O\nFriday O\nafter O\nlosing O\nthe O\nfirst O\nleg O\nof O\ntheir O\nqualifying O\ntie O\n4-1 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nMAURITANIA B-LOC\nDRAW O\nWITH O\nBENIN B-LOC\nIN O\nAFRICAN B-MISC\nNATIONS I-MISC\nCUP I-MISC\n. O\n\nNOUAKCHOTT B-LOC\n1996-08-31 O\n\nMauritania B-LOC\ndrew O\n0-0 O\nwith O\nBenin B-LOC\nin O\ntheir O\nAfrican B-MISC\nNations I-MISC\nCup I-MISC\npreliminary O\nround O\n, O\nsecond O\nleg O\nsoccer O\nmatch O\non O\nFriday O\n. O\n\nBenin B-LOC\nwon O\n4-1 O\non O\naggregate O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nYUGOSLAV B-MISC\nLEAGUE O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nBELGRADE B-LOC\n1996-08-31 O\n\nResults O\nof O\nYugoslav B-MISC\nleague O\n\nsoccer O\nmatches O\nplayed O\non O\nSaturday O\n: O\n\nDivision O\nA O\n\nHajduk B-ORG\n2 O\nProleter B-ORG\n( I-ORG\nZ I-ORG\n) I-ORG\n0 O\n\nZemun B-ORG\n1 O\nRad B-ORG\n( O\nB O\n) O\n0 O\n\nBorac B-ORG\n1 O\nMladost B-ORG\n( I-ORG\nL I-ORG\n) I-ORG\n2 O\n\nCukaricki B-ORG\n1 O\nVojvodina B-ORG\n0 O\n\nBuducnost B-ORG\n1 O\nRed B-ORG\nStar I-ORG\n3 O\n\nPartizan B-ORG\n6 O\nBecej B-ORG\n0 O\n\nStandings O\n( O\ntabulate O\nunder O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\ngoals O\n\nagainst O\n, O\npoints O\n) O\n: O\n\nRed B-ORG\nStar I-ORG\n4 O\n4 O\n0 O\n0 O\n9 O\n3 O\n12 O\n\nPartizan B-ORG\n4 O\n3 O\n1 O\n0 O\n13 O\n3 O\n10 O\n\nMladost B-ORG\n( I-ORG\nL I-ORG\n) I-ORG\n4 O\n2 O\n1 O\n1 O\n8 O\n5 O\n7 O\n\nVojvodina B-ORG\n4 O\n2 O\n1 O\n1 O\n5 O\n3 O\n7 O\n\nBecej B-ORG\n4 O\n2 O\n1 O\n1 O\n5 O\n7 O\n7 O\n\nHajduk B-ORG\n4 O\n2 O\n0 O\n2 O\n5 O\n3 O\n6 O\n\nCukaricki B-ORG\n4 O\n2 O\n0 O\n2 O\n6 O\n6 O\n6 O\n\nZemun B-ORG\n4 O\n1 O\n2 O\n1 O\n3 O\n3 O\n5 O\n\nRad B-ORG\n( I-ORG\nB I-ORG\n) I-ORG\n4 O\n1 O\n1 O\n2 O\n2 O\n3 O\n4 O\n\nBuducnost B-ORG\n4 O\n1 O\n0 O\n3 O\n4 O\n8 O\n3 O\n\nProleter B-ORG\n( I-ORG\nZ I-ORG\n) I-ORG\n4 O\n0 O\n1 O\n3 O\n2 O\n9 O\n1 O\n\nBorac B-ORG\n4 O\n0 O\n0 O\n4 O\n1 O\n10 O\n0 O\n\nDivision O\nB O\n\nSloboda B-ORG\n4 O\nMladost B-ORG\n( I-ORG\nBJ I-ORG\n) I-ORG\n0 O\n\nBuducnost B-ORG\n( I-ORG\nV I-ORG\n) I-ORG\n0 O\nOFK B-ORG\nBeograd I-ORG\n1 O\n\nRudar B-ORG\n0 O\nOFK B-ORG\nKikinda I-ORG\n1 O\n\nObilic B-ORG\n2 O\nZeleznik B-ORG\n( I-ORG\nB I-ORG\n) I-ORG\n0 O\n\nSutjeska B-ORG\n1 O\nLoznica B-ORG\n0 O\n\nRadnicki B-ORG\n( I-ORG\nN I-ORG\n) I-ORG\n- O\nSpartak B-ORG\n( O\nto O\nbe O\nplayed O\non O\nSunday O\n) O\n\nStandings O\n: O\n\nObilic B-ORG\n4 O\n4 O\n0 O\n0 O\n10 O\n1 O\n12 O\n\nOFK B-ORG\nKikinda I-ORG\n4 O\n3 O\n0 O\n1 O\n8 O\n3 O\n9 O\n\nSutjeska B-ORG\n4 O\n3 O\n0 O\n1 O\n7 O\n5 O\n9 O\n\nLoznica B-ORG\n4 O\n2 O\n0 O\n2 O\n7 O\n4 O\n6 O\n\nOFK B-ORG\nBeograd I-ORG\n4 O\n1 O\n3 O\n0 O\n5 O\n4 O\n6 O\n\nBuducnost B-ORG\n( I-ORG\nV I-ORG\n) I-ORG\n4 O\n2 O\n0 O\n2 O\n4 O\n5 O\n6 O\n\nSloboda B-ORG\n4 O\n1 O\n1 O\n2 O\n8 O\n8 O\n4 O\n\nSpartak B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n3 O\n4 O\n\nRadnicki B-ORG\n( I-ORG\nN I-ORG\n) I-ORG\n3 O\n1 O\n0 O\n2 O\n5 O\n6 O\n3 O\n\nZeleznik B-ORG\n( I-ORG\nB I-ORG\n) I-ORG\n4 O\n1 O\n0 O\n3 O\n4 O\n7 O\n3 O\n\nRudar B-ORG\n4 O\n1 O\n0 O\n3 O\n1 O\n7 O\n3 O\n\nMladost B-ORG\n( I-ORG\nBJ I-ORG\n) I-ORG\n4 O\n0 O\n1 O\n3 O\n2 O\n10 O\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nINCE B-PER\nEXPOSED O\nBY O\nGASCOIGNE B-PER\n'S O\nLATEST O\nPRANK O\n. O\n\nCHISINAU B-LOC\n, O\nMoldova B-LOC\n1996-08-31 O\n\nEngland B-LOC\n's O\nirrepressible O\nmidfielder O\nPaul B-PER\nGascoigne I-PER\nwas O\nup O\nto O\nhis O\nold O\ntricks O\non O\nSaturday O\n, O\npulling O\ndown O\nhis O\nteam O\nmate O\nPaul B-PER\nInce I-PER\n's O\ntrousers O\nin O\nfront O\nof O\nan O\nastonished O\ncrowd O\nin O\nMoldova B-LOC\n. O\n\nInce B-PER\nwas O\nclambering O\nover O\na O\nwall O\nat O\nthe O\nRepublican B-MISC\nstadium O\nin O\nChisinau B-LOC\nas O\nGlenn B-PER\nHoddle I-PER\n's O\nEngland B-LOC\nplayers O\ntried O\nto O\nescape O\nheavy O\nrain O\nduring O\nan O\nunder-21 O\nclash O\n. O\n\nGascoigne B-PER\n, O\nwhose O\ncompulsive O\npractical O\njoking O\nhas O\nlanded O\nhim O\nin O\ntrouble O\nin O\nthe O\npast O\n, O\ntugged O\ndown O\nthe O\nInter B-ORG\nMilan I-ORG\nplayer O\n's O\ntrousers O\nin O\nfront O\nof O\na O\ngroup O\nof O\npress O\nphotographers O\n. O\n\nHoddle B-PER\n, O\ncoaching O\nthe O\nside O\nfor O\nthe O\nfirst O\ntime O\n, O\ndeclined O\nto O\ncomment O\non O\nthe O\nincident O\n. O\n\nEngland B-LOC\nface O\nMoldova B-LOC\nin O\na O\nWorld B-MISC\nCup I-MISC\nqualifier O\nin O\nthe O\nsame O\nstadium O\non O\nSunday O\n. O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nTROFEJ B-MISC\nBEOGRAD I-MISC\nTOURNAMENT I-MISC\nRESULTS O\n. O\n\nBELGRADE B-LOC\n1996-08-31 O\n\nResults O\nin O\nthe O\nTrofej B-MISC\nBeograd I-MISC\n96 I-MISC\n\ninternational O\nbasketball O\ntournament O\non O\nSaturday O\n: O\n\nFifth O\nplace O\n: O\n\nBenetton B-ORG\n( O\nItaly B-LOC\n) O\n92 O\nDinamo B-ORG\n( O\nRussia B-LOC\n) O\n81 O\n( O\nhalftime O\n50-28 O\n) O\n\nThird O\nplace O\n: O\n\nAlba B-ORG\n( O\nGermany B-LOC\n) O\n75 O\nRed B-ORG\nStar I-ORG\n( O\nYugoslavia B-LOC\n) O\n70 O\n( O\n42-41 O\n) O\n\n-DOCSTART- O\n\nBASKETBALLSOCCER O\n- O\nTROFEJ B-MISC\nBEOGRAD I-MISC\nTOURNAMENT I-MISC\nRESULTS O\n. O\n\nBELGRADE B-LOC\n1996-08-31 O\n\nResults O\nin O\nthe O\nTrofej B-MISC\nBeograd I-MISC\n96 I-MISC\n\ninternational O\nbasketball O\ntournament O\non O\nSaturday O\n: O\n\nFifth O\nplace O\n: O\n\nBenetton B-ORG\n( O\nItaly B-LOC\n) O\n92 O\nDinamo B-ORG\n( O\nRussia B-LOC\n) O\n81 O\n( O\nhalftime O\n50-28 O\n) O\n\nThird O\nplace O\n: O\n\nAlba B-ORG\n( O\nGermany B-LOC\n) O\n75 O\nRed B-ORG\nStar I-ORG\n( O\nYugoslavia B-LOC\n) O\n70 O\n( O\n42-41 O\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nROMANIA B-LOC\nBEAT O\nLITHUANIA B-LOC\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nBUCHAREST B-LOC\n1996-08-31 O\n\nRomania B-LOC\nbeat O\nLithuania B-LOC\n3-0 O\n( O\nhalftime O\n1-0 O\n) O\nin O\na O\nWorld B-MISC\nCup I-MISC\nsoccer O\nEuropean B-MISC\ngroup O\n8 O\nqualifier O\non O\nSaturday O\n. O\n\nScorers O\n: O\n\nRomania B-LOC\n- O\nViorel B-PER\nMoldovan I-PER\n( O\n21st O\nminute O\n) O\n, O\nDan B-PER\nPetrescu I-PER\n( O\n65th O\n) O\n, O\nConstantin B-PER\nGalca I-PER\n( O\n77th O\n) O\n\nAttendence O\n: O\n9,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nARMENIA B-LOC\nAND O\nPORTUGAL B-LOC\nDRAW O\n0-0 O\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nYEREVAN B-LOC\n1996-08-31 O\n\nArmenia B-LOC\nand O\nPortugal B-LOC\ndrew O\n0-0 O\nin O\na O\nWorld B-MISC\nCup I-MISC\nsoccer O\nEuropean B-MISC\ngroup O\n9 O\nqualifier O\non O\nSaturday O\n. O\n\nAttendance O\n: O\n5,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nAZERBAIJAN B-LOC\nBEAT O\nSWITZERLAND B-LOC\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nBAKU B-LOC\n1996-08-31 O\n\nAzerbaijan B-LOC\nbeat O\nSwitzerland B-LOC\n1-0 O\n( O\nhalftime O\n1-0 O\n) O\nin O\ntheir O\nWorld B-MISC\nCup I-MISC\nsoccer O\nEuropean B-MISC\ngroup O\nthree O\nqualifying O\nmatch O\non O\nSaturday O\n. O\n\nScorer O\n: O\n\nVidadi B-PER\nRzayev I-PER\n( O\n28th O\n) O\n\nAttendance O\n: O\n20,000 O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nBENETTON B-ORG\nBEAT O\nDINAMO B-ORG\n92-81 O\n. O\n\nBELGRADE B-LOC\n1996-08-31 O\n\nBenetton B-ORG\nof O\nItaly B-LOC\nbeat O\nDinamo B-ORG\nof O\nRussia B-LOC\n92-81 O\n( O\nhalftime O\n50-28 O\n) O\nin O\na O\nfifth O\nplace O\nplay-off O\nin O\nthe O\nTrofej B-MISC\nBeograd I-MISC\n96 I-MISC\ninternational O\nbasketball O\ntournament O\non O\nSaturday O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSWEDEN B-LOC\nBEAT O\nLATVIA B-LOC\nIN O\nEUROPEAN B-MISC\nUNDER-21 O\nQUALIFIER O\n. O\n\nRIGA B-LOC\n1996-08-31 O\n\nSweden B-LOC\nbeat O\nLatvia B-LOC\n2-0 O\n( O\nhalftime O\n0-0 O\n) O\nin O\na O\nEuropean B-MISC\nunder-21 O\nsoccer O\nchampionship O\nqualifier O\non O\nSaturday O\n. O\n\nScorers O\n: O\nJoakim B-PER\nPersson I-PER\n81st O\nminute O\n, O\nDaniel B-PER\nAndersson I-PER\n( O\n89th O\n) O\n\nAttendance O\n: O\n300 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBELARUS B-LOC\nBEAT O\nESTONIA B-LOC\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nMINSK B-LOC\n1996-08-31 O\n\nBelarus B-LOC\nbeat O\nEstonia B-LOC\n1-0 O\n( O\nhalftime O\n1-0 O\n) O\nin O\na O\nWorld B-MISC\nCup I-MISC\nsoccer O\nEuropean B-MISC\ngroup O\n4 O\nqualifier O\non O\nSaturday O\n. O\n\nScorer O\n: O\nVladimir B-PER\nMakovsky I-PER\n( O\n35th O\n) O\n\nAttendance O\n: O\n6,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLAND B-LOC\nBEAT O\nMOLDOVA B-LOC\nIN O\nUNDER-21 O\nQUALIFIER O\n. O\n\nCHISINAU B-LOC\n1996-08-31 O\n\nEngland B-LOC\nbeat O\nMoldova B-LOC\n2-0 O\n( O\nhalftime O\n1-0 O\n) O\nin O\na O\nEuropean B-MISC\nUnder-21 O\nsoccer O\nchampionship O\ngroup O\n2 O\nqualifier O\non O\nSaturday O\n. O\n\nScorers O\n: O\nBruce B-PER\nDyer I-PER\n( O\n39th O\nminute O\n) O\n, O\nDarren B-PER\nEadie I-PER\n( O\n53rd O\n) O\n\nAttendance O\n: O\n850 O\n\n-DOCSTART- O\n\nSQUASH O\n- O\nHILL B-PER\nBRANDS O\nWORLD O\nCHAMPION O\nJANSHER B-PER\nA O\nCHEAT O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-31 O\n\nControversial O\nAustralian B-MISC\nAnthony B-PER\nHill I-PER\ncalled O\nJansher B-PER\nKhan I-PER\na O\ncheat O\nduring O\nhis O\nacrimonious O\ndefeat O\nby O\nthe O\nworld O\nnumber O\none O\nin O\nthe O\nHong B-MISC\nKong I-MISC\nOpen I-MISC\nsemifinals O\non O\nSaturday O\n. O\n\nThe O\nmatch O\nboiled O\nover O\nwhen O\nHill B-PER\nmade O\nto O\nwalk O\noff O\ncourt O\nafter O\nwhat O\nhe O\nclaimed O\nwas O\na O\ngame-winning O\npoint O\nin O\nthe O\nthird O\n. O\n\nWhen O\nthe O\nreferee O\ncalled O\nJansher B-PER\n's O\nreturn O\ngood O\nand O\nthe O\ndecision O\nwas O\naccepted O\nby O\nthe O\nplayer O\n, O\nHill B-PER\nshrieked O\nat O\nthe O\nPakistani B-MISC\n: O\n\" O\nYou O\ncheat O\n. O\n\" O\n\n\" O\nHe O\nwas O\nstanding O\nright O\nthere O\nand O\nknew O\nthe O\nshot O\nwas O\ndown O\nso O\nI O\ncalled O\nhim O\na O\ncheat O\n, O\n\" O\nsaid O\nHill B-PER\n, O\nwhose O\nsquash O\ncareer O\nhas O\nbeen O\nblighted O\nby O\nfines O\nand O\nsuspensions O\nfor O\nunacceptable O\nbehaviour O\n. O\n\n\" O\nHe O\nknew O\nit O\nwas O\ndown O\nand O\naccepted O\nwhat O\nI O\ncalled O\nhim O\nbecause O\nof O\nthat O\n. O\n\" O\n\nHill B-PER\nwon O\nthe O\ngame O\non O\nthe O\nnext O\npoint O\nand O\nsaid O\nlater O\nthat O\nJansher B-PER\nwas O\ngenerally O\nhonest O\non O\ncourt O\nbut O\nplayed O\nby O\nthe O\nreferee O\n's O\ndecision O\n. O\n\nThe O\nAustralian B-MISC\nhad O\nupset O\nJansher B-PER\n's O\nrhythm O\nwith O\nhis O\nmixture O\nof O\ngamesmanship O\nand O\nfluent O\nstroke-making O\nbut O\neventually O\nsuccumbed O\n15-7 O\n17-15 O\n14-15 O\n15-8 O\n. O\n\n\" O\nI O\nchanged O\nmy O\nstrategy O\nagainst O\nhim O\ntoday O\nand O\nhad O\nhim O\nrattled O\n, O\n\" O\nhe O\nadded O\n. O\n\nHe O\nis O\nnot O\nas O\nfit O\nas O\nhe O\nused O\nto O\nbe O\nbe O\nbut O\nwas O\ntoo O\ngood O\nfor O\nme O\nin O\nthe O\nend O\n. O\n\nI O\nshook O\nhim O\na O\nbit O\nbut O\nhe O\nwill O\ncome O\nout O\nnext O\ntime O\nand O\nbe O\na O\nbetter O\nplayer O\nfor O\nit O\n-- O\nthat O\n's O\nJansher O\n. O\n\" O\n\nJansher B-PER\nsaid O\nthat O\nhe O\nwas O\ndisturbed O\nto O\nbe O\ncalled O\na O\ncheat O\n. O\n\" O\n\nWhat O\nhe O\ndid O\nwas O\nbad O\nfor O\nsquash O\n, O\nbad O\nfor O\nthe O\ncrowd O\nand O\nbad O\nfor O\nthe O\nsponsors O\n. O\n\n\" O\nWe O\nare O\ntrying O\nto O\nbuild O\nup O\nsquash O\nlike O\ntennis O\nand O\nplayers O\nshould O\nnot O\nsay O\nthings O\nlike O\nthat O\n. O\n\n\" O\nI O\nthink O\nthe O\nProfessional B-ORG\nSquash I-ORG\nAssociation I-ORG\nshould O\nlook O\ninto O\nthis O\nmatter O\nand O\ndeal O\nwith O\nit O\nproperly O\n. O\n\nI O\nam O\nnot O\ncalling O\nfor O\nhim O\nto O\nbe O\nbanned O\nbut O\nthey O\nhave O\nto O\ntake O\nsome O\naction O\n. O\n\" O\n\nJansher B-PER\n, O\nbidding O\nfor O\nan O\neighth O\nHong B-MISC\nKong I-MISC\nOpen I-MISC\ntitle O\n, O\nplays O\nsecond-seeded O\nAustralian B-MISC\nRodney B-PER\nEyles I-PER\nin O\nthe O\nfinal O\n. O\n\nEyles B-PER\nplayed O\nhis O\nbest O\nsquash O\nof O\nthe O\ntournament O\nto O\nbeat O\nfourth-seeded O\nPeter B-PER\nNicol I-PER\nof O\nScotland B-LOC\n15-10 O\n8-15 O\n15-10 O\n15-4 O\n. O\n\nEyles B-PER\n, O\nwho O\ndefeated O\nJansher B-PER\nin O\nthe O\nsemifinals O\nof O\nthe O\nPortuguese B-MISC\nOpen I-MISC\nin O\n1993 O\n, O\nsaid O\nthat O\nhe O\nwould O\nlike O\nto O\nwin O\nfor O\nthe O\ngood O\nof O\nthe O\ngame O\n. O\n\n\" O\nI O\nhave O\nnothing O\nagainst O\nJansher B-PER\nbut O\nit O\nwill O\nbe O\ngreat O\nif O\nI O\ncould O\nbeat O\nhim O\n, O\n\" O\nsaid O\nEyles B-PER\n. O\n\" O\n\nMy O\nbiggest O\nproblem O\nagainst O\nJansher B-PER\nis O\nconcentration O\n. O\n\nI O\nwant O\nto O\nbeat O\nhim O\nso O\nbadly O\nthat O\nI O\njust O\ncannot O\nget O\nit O\ntogether O\n. O\n\" O\n\n-DOCSTART- O\n\nSQUASH O\n- O\nHONG B-MISC\nKONG I-MISC\nOPEN I-MISC\nSEMIFINAL O\nRESULTS O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-31 O\n\nSemifinal O\nresults O\nin O\nthe O\nHong B-MISC\nKong I-MISC\nOpen I-MISC\non O\nSaturday O\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n1 O\n- O\nJansher B-PER\nKhan I-PER\n( O\nPakistan B-LOC\n) O\nbeat O\nAnthony B-PER\nHill I-PER\n( O\nAustralia B-LOC\n) O\n15-7 O\n17-15 O\n14-15 O\n15-8 O\n2 O\n- O\nRodney B-PER\nEyles I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\n4 O\n- O\nPeter B-PER\nNicol I-PER\n( O\nScotland B-LOC\n) O\n15-10 O\n8-15 O\n15-10 O\n15-4 O\n\n-DOCSTART- O\n\nGOLF O\n- O\nPARNEVIK B-PER\nTAKES O\nONE-SHOT O\nLEAD O\nAT O\nGREATER B-MISC\nMILWAUKEE I-MISC\nOPEN I-MISC\n. O\n\nMILWAUKEE B-LOC\n, O\nWisconsin B-LOC\n1996-08-31 O\n\nJesper B-PER\nParnevik I-PER\nof O\nSweden B-LOC\nfired O\na O\ncourse O\nrecord-tying O\neight-under-par O\n63 O\nSaturday O\nto O\ntake O\na O\none-shot O\nlead O\ninto O\nthe O\nfinal O\nround O\nof O\nthe O\n$ O\n1.2 O\nmillion O\nGreater B-MISC\nMilwaukee I-MISC\nOpen I-MISC\n. O\n\nParnevik B-PER\n, O\nwho O\nis O\nseeking O\nhis O\nfirst O\nPGA B-MISC\nTour I-MISC\nvictory O\n, O\nmoved O\nto O\n19-under O\n194 O\nfor O\nthe O\ntournament O\n. O\n\nParnevik B-PER\ntied O\nthe O\n18-hole O\nrecord O\nset O\nby O\nLoren B-PER\nRoberts I-PER\nin O\n1994 O\nat O\nthe O\nBrown B-LOC\nDeer I-LOC\nPark I-LOC\nGolf I-LOC\nCourse I-LOC\nand O\nalso O\nequalled O\nSaturday O\nby O\nGreg B-PER\nKraft I-PER\n. O\n\nNolan B-PER\nHenke I-PER\n, O\nwho O\nled O\nby O\ntwo O\nstrokes O\nentering O\nthe O\nthird O\nround O\n, O\ncarded O\na O\nfour-under O\n67 O\nand O\nwas O\none O\nstroke O\nback O\nat O\n18-under O\n195 O\n. O\n\nHe O\nis O\nstriving O\nfor O\nhis O\nfourth O\ncareer O\nPGA B-MISC\nTour I-MISC\nvictory O\nand O\nfirst O\nsince O\nthe O\n1993 B-MISC\nBellSouth I-MISC\nClassic I-MISC\n. O\n\nTiger B-PER\nWoods I-PER\n, O\nwho O\nmade O\nthe O\ncut O\nin O\nhis O\nfirst O\ntournament O\nas O\na O\nprofessional O\n, O\nshot O\na O\ntwo-over-par O\n73 O\nand O\nwas O\nfour O\nunder O\nfor O\nthe O\ntournament O\n. O\n\nThe O\n20-year-old O\nWoods B-PER\n, O\nwho O\nturned O\nprofessional O\nTuesday O\nafter O\nwinning O\nan O\nunprecedented O\nthird O\nsuccessive O\nU.S. B-MISC\nAmateur I-MISC\nChampionship I-MISC\n, O\nstruggled O\non O\nthe O\nfront O\nnine O\n, O\nbogeying O\nthe O\nfirst O\nand O\nseventh O\nholes O\nand O\ndouble-bogeying O\nthe O\npar-four O\n, O\n359-yard O\nninth O\nhole O\n. O\n\nAfter O\nbogeying O\nthe O\n10th O\nhole O\nto O\nmove O\nto O\nfour-over O\nfor O\nthe O\nround O\n, O\nhe O\nrallied O\nfor O\nbirdies O\non O\n15 O\nand O\n18 O\n. O\n\nAfter O\nParnevik B-PER\nstarted O\noff O\nhis O\nround O\nby O\nparring O\nthe O\nfirst O\nhole O\nand O\nbogeying O\nthe O\nsecond O\n, O\nthe O\nSwede B-MISC\nbirdied O\nsix O\nof O\nthe O\nnext O\nseven O\nholes O\n. O\n\nParnevik B-PER\ncontinued O\nto O\nstorm O\nthrough O\nthe O\ncourse O\n, O\nbirdying O\nthree O\nholes O\non O\nthe O\nback O\nnine O\n, O\nincluding O\ntwo O\nfrom O\n12 O\nfeet O\nout O\non O\nthe O\n15th O\nand O\n17th O\nholes O\n. O\n\n\" O\nI O\nca O\nn't O\nremember O\nwhen O\nI O\n've O\nputted O\nthis O\nwell O\n, O\n\" O\nsaid O\nParnevik B-PER\n. O\n\" O\n\nI O\nwas O\ndisappointed O\nwhen O\na O\n12-footer O\ndid O\nn't O\ngo O\nin O\n. O\n\n\" O\nMy O\ngame O\nfeels O\nvery O\ngood O\n. O\n\nI O\n've O\nbeen O\nfading O\nmy O\ndriver O\nbut O\ntoday O\nwhenever O\nI O\nset O\nup O\nfor O\na O\nfade O\nit O\nwent O\nstraight O\n. O\n\nWhenever O\neveryone O\n's O\nmaking O\nbirdies O\n, O\nyou O\nnever O\nwant O\nto O\nbe O\neven O\npar O\n. O\n\" O\n\nHenke B-PER\nhad O\na O\nbogey-free O\nround O\nand O\nbirdied O\nfour O\nholes O\n, O\nincluding O\na O\n45-footer O\non O\nthe O\npar-three O\n215-yard O\nseventh O\nhole O\nand O\none O\nfrom O\n12 O\nfeet O\nout O\non O\nthe O\n12th O\nhole O\n. O\n\n\" O\nI O\ndid O\nn't O\nhit O\nit O\nvery O\nwell O\ntoday O\n, O\n\" O\nsaid O\nHenke B-PER\n. O\n\" O\n\nJasper B-PER\nblew O\nright O\nby O\nme O\n. O\n\nOnce O\nhe O\ndid O\n, O\nI O\nknew O\nI O\nhad O\nto O\nmake O\nbirdies O\njust O\nto O\nkeep O\nup O\n. O\n\nI O\nmade O\nsome O\nreally O\ngood O\npars O\n. O\n\nI O\nbasically O\npicked O\nup O\nwhere O\nI O\nleft O\noff O\nyesterday O\nafternoon O\n. O\n\n\" O\nRight O\nnow O\n, O\nI O\nca O\nn't O\nput O\nmy O\nfinger O\non O\nwhat O\n's O\nwrong O\n. O\n\" O\n\nBob B-PER\nEstes I-PER\nshot O\na O\n67 O\nfor O\nsole O\npossession O\nof O\nthird O\nplace O\nat O\n15-under O\n. O\n\nSteve B-PER\nStricker I-PER\n, O\nwho O\ntied O\nfor O\nsecond O\nat O\nlast O\nweek O\n's O\nWorld B-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\n, O\nand O\nStuart B-PER\nAppleby I-PER\nwere O\nboth O\nfive O\nshots O\noff O\nthe O\nlead O\nat O\n14 O\nunder O\n. O\n\nDuffy B-PER\nWaldorf I-PER\n, O\nwho O\nalso O\ntied O\nfor O\nsecond O\nat O\nthe O\nWorld B-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\n, O\ncarded O\na O\n70 O\nto O\nlead O\na O\ngroup O\nof O\nsix O\ngolfers O\nat O\n13 O\nunder O\n, O\nincluding O\nKraft B-PER\n. O\n\nThe O\ntop O\nfour O\non O\nthe O\nPGA B-MISC\nTour I-MISC\nmoney O\nlist O\nall O\nskipped O\nthe O\ntournament O\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nSPAIN B-LOC\n, O\nU.S. B-LOC\nTEAMS O\nOPEN O\nON O\nROAD O\nFOR O\n1997 B-MISC\nFED I-MISC\nCUP I-MISC\n. O\n\nRichard B-PER\nFinn I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-31 O\n\nThis O\nyear O\n's O\nFed B-MISC\nCup I-MISC\nfinalists O\n-- O\ndefending O\nchampion O\nSpain B-LOC\nand O\nthe O\nUnited B-LOC\nStates I-LOC\n-- O\nwill O\nhit O\nthe O\nroad O\nto O\nopen O\nthe O\n1997 O\nwomen O\n's O\ninternational O\nteam O\ncompetition O\n, O\nbased O\non O\nthe O\ndraw O\nconducted O\nSaturday O\nat O\nthe O\nU.S. B-MISC\nOpen I-MISC\n. O\n\nSpain B-LOC\ntravels O\nto O\nBelgium B-LOC\n, O\nwhile O\nthe O\nU.S. B-LOC\nteam O\nheads O\nto O\nthe O\nNetherlands B-LOC\nfor O\nfirst-round O\nmatches O\nMarch O\n1-2 O\n. O\n\nThe O\nother O\ntwo O\nfirst-round O\nties O\nwill O\npit O\nhosts O\nGermany B-LOC\nagainst O\nthe O\nCzech B-LOC\nRepublic I-LOC\nand O\nvisiting O\nFrance B-LOC\nagainst O\nJapan B-LOC\n. O\n\nThe O\nsemifinals O\nare O\nJuly O\n19-20 O\n, O\nand O\nthe O\nfinal O\nSeptember O\n27- O\n28 O\n. O\n\nLife O\non O\nthe O\nroad O\nthis O\nyear O\ndid O\nnot O\nslow O\nthe O\nAmericans B-MISC\n, O\nwho O\nwill O\ntry O\nto O\navenge O\ntheir O\n3-2 O\ndefeat O\nin O\nthe O\nfinal O\nlast O\nyear O\nwhen O\nthey O\nhost O\nSpain B-LOC\non O\nSeptember O\n28-29 O\nin O\nAtlantic B-LOC\nCity I-LOC\n. O\n\n\" O\nLast O\nyear O\nwe O\nstood O\non O\nthe O\ncourt O\nafter O\nwe O\nhad O\nlost O\nand O\nwe O\nput O\nout O\nhands O\ntogether O\nand O\nmade O\nit O\nour O\ncommittment O\nto O\nbring O\nback O\nthe O\nCup B-MISC\n, O\n\" O\nU.S. B-LOC\ncaptain O\nBillie B-PER\nJean I-PER\nKing I-PER\nsaid O\nat O\nthe O\ndraw O\n. O\n\" O\n\nThat O\nis O\nour O\nsole O\ngoal O\n. O\n\" O\n\nThe O\nUnited B-LOC\nStates I-LOC\nedged O\nAustria B-LOC\nin O\nSalzburg B-LOC\n3-2 O\nin O\nthe O\nopening O\nround O\nin O\nApril O\n, O\nand O\nthen O\nblanked O\nJapan B-LOC\n5-0 O\nin O\nNagoya B-LOC\nlast O\nmonth O\nin O\nthe O\nsemifinals O\n. O\n\nThe O\nvictory O\nagainst O\nJapan B-LOC\nmarked O\nthe O\nFed B-MISC\nCup I-MISC\ndebut O\nof O\nMonica B-PER\nSeles I-PER\n, O\nwho O\nbecame O\na O\nnaturalised O\nU.S. B-LOC\ncitizen O\nin O\n1994 O\n. O\n\nSeles B-PER\neasily O\nwon O\nboth O\nher O\nsingles O\nmatches O\nand O\nKing B-PER\nis O\ncounting O\non O\nthe O\nco-world O\nnumber O\none O\nto O\nlead O\nthe O\nteam O\nagain O\n. O\n\n\" O\nI O\ntold O\nMonica B-PER\nwe O\nneed O\nher O\nif O\nwe O\nwant O\nto O\nwin O\n, O\n\" O\nKing B-PER\nsaid O\n. O\n\nSeles B-PER\n's O\nsore O\nleft O\nshoulder O\nand O\na O\nwrist O\ninjury O\nto O\nFed B-MISC\nCup I-MISC\nveteran O\nMary B-PER\nJoe I-PER\nFernandez I-PER\nhave O\nforced O\nKing B-PER\nto O\ntake O\na O\nwait O\nand O\nsee O\nattitude O\nregarding O\nher O\nsquad O\nfor O\nthe O\nbest-of-five O\nmatch O\n. O\n\nFernandez B-PER\nwas O\nforced O\nto O\nwithdraw O\nfrom O\nthe O\nU.S. B-MISC\nOpen I-MISC\n. O\n\n\" O\nWe O\nwill O\nwait O\nuntil O\nthe O\nlast O\nminute O\nso O\nwe O\ncheck O\nwith O\neverybody O\nand O\ntheir O\ninjuries O\n, O\n\" O\nsaid O\nKing B-PER\n. O\n\" O\n\nWhat O\nwe O\nlike O\nwould O\nbe O\nSeles B-PER\n, O\n( O\nOlympic B-MISC\nchampion O\nLindsay B-PER\n) O\nDavenport B-PER\nand O\nMary B-PER\nJoe I-PER\nFernandez I-PER\n. O\n\" O\n\nIf O\nshe O\ncan O\nget O\nthat O\nthreesome O\ntogether O\n, O\nKing B-PER\nwill O\nfeel O\ngood O\nabout O\nher O\nchances O\nagainst O\nthe O\nSpain B-LOC\n's O\nformidable O\nduo O\nof O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\nand O\nConchita B-PER\nMartinez I-PER\n. O\n\n\" O\nTo O\nbe O\na O\ngreat O\ncoach O\nyou O\nhave O\nto O\nhave O\nthe O\nright O\nhorses O\nand O\nI O\ngot O\nthe O\nright O\nhorses O\n, O\n\" O\nsaid O\nKing B-PER\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nSATURDAY O\n'S O\nRESULTS O\nFROM O\nTHE O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-31 O\n\nResults O\nfrom O\nthe O\nU.S. B-MISC\nOpen I-MISC\nTennis I-MISC\nChampionships I-MISC\nat O\nthe O\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\non O\nSaturday O\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nWomen O\n's O\nsingles O\n, O\nthird O\nround O\n1 O\n- O\nSteffi B-PER\nGraf I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nNatasha B-PER\nZvereva I-PER\n( O\nBelarus B-LOC\n) O\n6-4 O\n6-2 O\n16 O\n- O\nMartina B-PER\nHingis I-PER\n( O\nSwitzerland B-LOC\n) O\nbeat O\nNaoko B-PER\nKijimuta I-PER\n( O\nJapan B-LOC\n) O\n6-2 O\n6-2 O\nJudith B-PER\nWiesner I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nPetra B-PER\nLangrova I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n6 O\n- O\n2 O\n6-0 O\n\nMen O\n's O\nsingles O\n, O\nthird O\nround O\n13 O\n- O\nThomas B-PER\nEnqvist I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nPablo B-PER\nCampana I-PER\n( O\nEcuador B-LOC\n) O\n6-4 O\n6-4 O\n6-2 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nDRAW O\nFOR O\n1997 B-MISC\nFED I-MISC\nCUP I-MISC\nWOMEN O\n'S O\nTEAM O\nTOURNAMENT O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-31 O\n\nDraw O\nfor O\nthe O\nwomen O\n's O\n1997 B-MISC\nFed I-MISC\nCup I-MISC\nteam O\ntennis O\nchampionships O\n, O\nas O\nconducted O\nat O\nthe O\nU.S. B-MISC\nOpen I-MISC\non O\nSaturday O\n: O\n\nWorld O\nGroup O\nI O\n, O\nfirst O\nround O\n( O\nMarch O\n1-2 O\n) O\n\nUnited B-LOC\nStates I-LOC\nat O\nNetherlands B-LOC\n\nCzech B-LOC\nRepublic I-LOC\nat O\nGermany B-LOC\n\nFrance B-LOC\nat O\nJapan B-LOC\n\nSpain B-LOC\nat O\nBelgium B-LOC\n\n( O\nsemifinals O\nJuly O\n19-20 O\n, O\nand O\nfinals O\nSeptember O\n27-28 O\n) O\n\nWorld O\nGroup O\nII O\n, O\nfirst O\nround O\n( O\nMarch O\n1-2 O\n) O\n\nAustria B-LOC\nat O\nCroatia B-LOC\n\nSwitzerland B-LOC\nat O\nSlovak B-LOC\nRepublic I-LOC\n\nArgentina B-LOC\nat O\nSouth B-LOC\nKorea I-LOC\n\nAustralia B-LOC\nat O\nSouth B-LOC\nAfrica I-LOC\n\n-DOCSTART- O\n\nSOCCER O\n- O\nU.S. B-LOC\nBEAT O\nEL B-LOC\nSALVADOR I-LOC\n3-1 O\n. O\n\nLOS B-LOC\nANGELES I-LOC\n1996-08-30 O\n\nThe O\nUnited B-LOC\nStates I-LOC\nbeat O\nEl B-LOC\nSalvador I-LOC\n3-1 O\n( O\nhalftime O\n1-0 O\n) O\nin O\nan O\ninternational O\nsoccer O\nfriendly O\non O\nFriday O\n. O\n\nScorers O\n: O\n\nU.S. B-LOC\n- O\nJoe-Max B-PER\nMoore I-PER\n( O\n3rd O\nminute O\n, O\n88th O\non O\npenalty O\nkick O\n) O\n, O\nEric B-PER\nWynalda I-PER\n( O\n61st O\n) O\n\nEl B-LOC\nSalvador I-LOC\n- O\nLuis B-PER\nLazo I-PER\n( O\n61st O\n) O\n\nAttendance O\n- O\n18,661 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nFRIDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-31 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nFriday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n75 O\n59 O\n.560 O\n- O\n\nBALTIMORE B-ORG\n71 O\n63 O\n.530 O\n4 O\n\nBOSTON B-ORG\n69 O\n66 O\n.511 O\n6 O\n1/2 O\n\nTORONTO B-ORG\n63 O\n72 O\n.467 O\n12 O\n1/2 O\n\nDETROIT B-ORG\n49 O\n86 O\n.363 O\n26 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n80 O\n54 O\n.597 O\n- O\n\nCHICAGO B-ORG\n72 O\n64 O\n.529 O\n9 O\n\nMINNESOTA B-ORG\n67 O\n68 O\n.496 O\n13 O\n1/2 O\n\nMILWAUKEE B-ORG\n65 O\n71 O\n.478 O\n16 O\n\nKANSAS B-ORG\nCITY I-ORG\n61 O\n75 O\n.449 O\n20 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n76 O\n58 O\n.567 O\n- O\n\nSEATTLE B-ORG\n70 O\n64 O\n.522 O\n6 O\n\nOAKLAND B-ORG\n65 O\n72 O\n.474 O\n12 O\n1/2 O\n\nCALIFORNIA B-ORG\n62 O\n73 O\n.459 O\n14 O\n1/2 O\n\nSATURDAY O\n, O\nAUGUST O\n31 O\nSCHEDULE O\n\nKANSAS B-ORG\nCITY I-ORG\nAT O\nDETROIT B-LOC\n\nBALTIMORE B-ORG\nAT O\nSEATTLE B-LOC\n\nCHICAGO B-ORG\nAT O\nTORONTO B-LOC\n\nMINNESOTA B-ORG\nAT O\nMILWAUKEE B-LOC\n\nCLEVELAND B-ORG\nAT O\nTEXAS B-LOC\n\nBOSTON B-ORG\nAT O\nOAKLAND B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nCALIFORNIA B-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n84 O\n50 O\n.627 O\n- O\n\nMONTREAL B-ORG\n71 O\n62 O\n.534 O\n12 O\n1/2 O\n\nFLORIDA B-ORG\n65 O\n70 O\n.481 O\n19 O\n1/2 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n76 O\n.437 O\n25 O\n1/2 O\n\nPHILADELPHIA B-ORG\n54 O\n81 O\n.400 O\n30 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nHOUSTON B-ORG\n73 O\n63 O\n.537 O\n- O\n\nST B-ORG\nLOUIS I-ORG\n70 O\n65 O\n.519 O\n2 O\n1/2 O\n\nCHICAGO B-ORG\n66 O\n67 O\n.496 O\n5 O\n1/2 O\n\nCINCINNATI B-ORG\n66 O\n68 O\n.493 O\n6 O\n\nPITTSBURGH B-ORG\n56 O\n78 O\n.418 O\n16 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n76 O\n60 O\n.559 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n73 O\n61 O\n.545 O\n2 O\n\nCOLORADO B-ORG\n70 O\n66 O\n.515 O\n6 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n58 O\n74 O\n.439 O\n16 O\n\nSATURDAY O\n, O\nAUGUST O\n31 O\nSCHEDULE O\n\nATLANTA B-ORG\nAT O\nCHICAGO B-LOC\n\nHOUSTON B-ORG\nAT O\nPITTSBURGH B-LOC\n\nSAN B-ORG\nFRANCISCO I-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nFLORIDA B-ORG\nAT O\nCINCINNATI B-LOC\n\nLOS B-ORG\nANGELES I-ORG\nAT O\nPHILADELPHIA B-LOC\n\nSAN B-ORG\nDIEGO I-ORG\nAT O\nMONTREAL B-LOC\n\nCOLORADO B-ORG\nAT O\nST B-LOC\nLOUIS I-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nFRIDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-31 O\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\n\nBaseball O\ngames O\nplayed O\non O\nFriday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nAmerican B-MISC\nLeague I-MISC\n\nDETROIT B-ORG\n4 O\nKansas B-ORG\nCity I-ORG\n0 O\n\nChicago B-ORG\n11 O\nTORONTO B-ORG\n2 O\n\nMILWAUKEE B-ORG\n5 O\nMinnesota B-ORG\n4 O\n( O\nin O\n12 O\n) O\n\nTEXAS B-ORG\n5 O\nCleveland B-ORG\n3 O\n\nNew B-ORG\nYork I-ORG\n6 O\nCALIFORNIA B-ORG\n2 O\n\nOAKLAND B-ORG\n7 O\nBoston B-ORG\n0 O\n\nBaltimore B-ORG\n5 O\nSEATTLE B-ORG\n2 O\n\nNational B-MISC\nLeague I-MISC\n\nCHICAGO B-ORG\n3 O\nAtlanta B-ORG\n2 O\n( O\n1st O\ngame O\n) O\n\nAtlanta B-ORG\n6 O\nCHICAGO B-ORG\n5 O\n( O\n2nd O\ngame O\n) O\n\nFlorida B-ORG\n3 O\nCINCINNATI B-ORG\n1 O\n\nSan B-ORG\nDiego I-ORG\n6 O\nMONTREAL B-ORG\n0 O\n\nLos B-ORG\nAngeles I-ORG\n7 O\nPHILADELPHIA B-ORG\n6 O\n( O\nin O\n12 O\n) O\n\nHouston B-ORG\n10 O\nPITTSBURGH B-ORG\n0 O\n\nSan B-ORG\nFrancisco I-ORG\n6 O\nNEW B-ORG\nYORK I-ORG\n4 O\n\nST B-ORG\nLOUIS I-ORG\n7 O\nColorado B-ORG\n4 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nKEVIN B-PER\nBROWN I-PER\nLOWERS O\nERA B-MISC\nAS O\nMARLINS B-ORG\nBEAT O\nREDS B-ORG\n. O\n\nCINCINNATI B-LOC\n1996-08-31 O\n\nMajor O\nleague O\nERA B-MISC\nleader O\nKevin B-PER\nBrown I-PER\nthrew O\nan O\neight-hitter O\nand O\nDevon B-PER\nWhite I-PER\n's O\nRBI B-MISC\ndouble O\nsnapped O\na O\nfifth-inning O\ntie O\nas O\nthe O\nFlorida B-ORG\nMarlins I-ORG\nbeat O\nthe O\nCincinnati B-ORG\nReds I-ORG\n3-1 O\nfor O\ntheir O\nseventh O\nstraight O\nwin O\nFriday O\n. O\n\nBrown B-PER\n( O\n14-10 O\n) O\ntied O\nTodd B-PER\nStottlemyre I-PER\nof O\nthe O\nCardinals B-ORG\nfor O\nthe O\nNational B-MISC\nLeague I-MISC\nlead O\nwith O\nhis O\nfifth O\ncomplete O\ngame O\nand O\nlowered O\nhis O\nmajor O\nleague-leading O\nearned O\nrun O\naverage O\nfrom O\n1.96 O\nto O\n1.92 O\n. O\n\nHe O\nstruck O\nout O\neight O\nand O\ndid O\nnot O\nwalk O\na O\nbatter O\n. O\n\nBrown B-PER\nthrew O\n119 O\npitches O\nand O\nwon O\nfor O\nthe O\nthird O\ntime O\nin O\nas O\nmany O\nstarts O\nagainst O\nthe O\nReds B-ORG\nthis O\nseason O\n. O\n\n\" O\nBolesy B-PER\n( O\nFlorida B-ORG\nmanager O\nJohn B-PER\nBoles I-PER\n) O\ntold O\nme O\nyesterday O\n, O\n' O\nYou O\nhave O\nto O\ngo O\nnine O\ntomorrow O\n, O\n' O\n\" O\nBrown B-PER\nsaid O\n. O\n\n\" O\nIn O\nthe O\nearly O\ninnings O\n, O\nI O\nwas O\nstruggling O\n, O\nI O\nwas O\njust O\ntrying O\nto O\nmake O\nit O\nfrom O\npitch O\nto O\npitch O\n. O\n\nI O\ngave O\nup O\na O\nlot O\nof O\nhits O\nin O\nthe O\nearly O\ninnings O\nand O\nI O\nwas O\nn't O\nthinking O\nabout O\nthe O\nseventh O\n, O\neighth O\nor O\nninth O\n. O\n\nI O\nwas O\nn't O\nsatisfied O\nwith O\nany O\nof O\nmy O\npitches O\nand O\nI O\ndid O\na O\nbetter O\njob O\nof O\nmoving O\nthe O\nball O\naround O\nin O\nthe O\nlater O\ninnings O\n. O\n\" O\n\n\" O\nHe O\nhas O\na O\ndevastating O\nsinker O\n, O\n\" O\nobserved O\nReds B-ORG\nmanager O\nRay B-PER\nKnight I-PER\n. O\n\" O\n\nThe O\nguys O\nsay O\nit O\nmoved O\nmore O\nthan O\neveryone O\nin O\nthe O\nleague O\n. O\n\nI O\nremember O\nNolan B-PER\nRyan I-PER\nsaying O\nin O\n' O\n91 O\nor O\n' O\n92 O\nthat O\nhe O\nwas O\nthe O\nbest O\nyoung O\npitcher O\ncoming O\naround O\nin O\na O\nlong O\ntime O\nand O\nhe O\nsaw O\n( B-PER\nTom I-PER\n) I-PER\nSeaver I-PER\nand O\n( B-PER\nJerry I-PER\n) I-PER\nKoosman I-PER\nwhen O\nthey O\nwere O\nstarting O\n. O\n\" O\n\nIn O\nPhiladelphia B-LOC\n, O\nDelino B-PER\nDeShields I-PER\n's O\ntriple O\nin O\nthe O\ntop O\nof O\nthe O\n12th O\noff O\nJeff B-PER\nParrett I-PER\n( O\n2-3 O\n) O\nscored O\nChad B-PER\nCurtis I-PER\nand O\nlifted O\nthe O\nLos B-ORG\nAngeles I-ORG\nDodgers I-ORG\nto O\na O\n7-6 O\nvictory O\nover O\nthe O\nPhillies B-ORG\n. O\n\nLos B-ORG\nAngeles I-ORG\nwon O\nfor O\nthe O\nseventh O\ntime O\nin O\neight O\ngames O\n. O\n\nDarren B-PER\nDreifort I-PER\n( O\n1-1 O\n) O\npicked O\nup O\nthe O\nwin O\nafter O\nallowing O\na O\nhit O\nand O\na O\nwalk O\nover O\n2 O\n1/3 O\nscoreless O\ninnings O\n. O\n\nTodd B-PER\nWorrell I-PER\nworked O\nthe O\n12th O\nto O\nearn O\nhis O\nleague-leading O\n37th O\nsave O\n. O\n\nThe O\nPhillies B-ORG\nhave O\ndropped O\nfive O\nof O\ntheir O\nlast O\nsix O\noverall O\n, O\nand O\nnine O\nof O\n11 O\nat O\nhome O\n. O\n\nBilly B-PER\nAshley I-PER\nbelted O\na O\nthree-run O\nhomer O\nfor O\nLos B-ORG\nAngeles I-ORG\n. O\n\nIn O\nChicago B-LOC\n, O\nthe O\nBraves B-ORG\nand O\nCubs B-ORG\nsplit O\na O\ndoubleheader O\n. O\n\nIn O\nthe O\nfirst O\ngame O\n, O\nRyne B-PER\nSandberg I-PER\nsnapped O\nan O\neighth-inning O\ntie O\nwith O\nan O\ninfield O\nsingle O\nand O\nKevin B-PER\nFoster I-PER\n( O\n6-2 O\n) O\noutdueled O\nAtlanta B-ORG\n's O\nTom B-PER\nGlavine I-PER\n( O\n13-8 O\n) O\nfor O\nhis O\nthird O\nstraight O\nwin O\n, O\n3-2 O\n. O\n\nFoster B-PER\n, O\na O\n.333 O\nhitter O\n, O\nhelped O\nhis O\nown O\ncause O\nin O\nthe O\nsecond O\nwith O\na O\ntwo-run O\nsingle O\n. O\n\nThe O\nBraves B-ORG\ntook O\nthe O\nsecond O\ngame O\nwhen O\nChipper B-PER\nJones I-PER\nsingled O\nhome O\nthe O\ntying O\nrun O\nin O\nthe O\ntop O\nof O\nthe O\nninth O\nand O\nAndruw B-PER\nJones I-PER\ntook O\nadvantage O\nof O\na O\npoor O\nthrow O\nto O\nscore O\nthe O\ngo-ahead O\nrun O\non O\na O\nsacrifice O\nfly O\nfor O\na O\n6-5 O\nvictory O\n. O\n\nCubs B-ORG\nshortstop O\nJose B-PER\nHernandez I-PER\ncommitted O\nthree O\nof O\nChicago B-LOC\n's O\nfour O\nerrors O\n. O\n\nMike B-PER\nMordecai I-PER\nsingled O\n, O\ndoubled O\nand O\nhomered O\nfor O\nAtlanta B-LOC\n, O\nwhich O\nhas O\nwon O\n14 O\nof O\nits O\nlast O\n19 O\ngames O\nand O\nhas O\nthe O\nbest O\nrecord O\nin O\nthe O\nmajors O\n, O\n84-50 O\n. O\n\nIn O\nMontreal B-LOC\n, O\nScott B-PER\nSanders I-PER\nallowed O\none O\nhit O\nover O\neight O\ninnings O\nand O\nWally B-PER\nJoyner I-PER\nhit O\na O\ntwo-run O\nsingle O\nin O\na O\nfour-run O\nthird O\nas O\nthe O\nSan B-ORG\nDiego I-ORG\nPadres I-ORG\nblanked O\nthe O\nExpos B-ORG\n6-0 O\nfor O\ntheir O\nsixth O\nstraight O\nwin O\n. O\n\nSanders B-PER\n( O\n8-4 O\n) O\nstruck O\nout O\n10 O\nand O\nwalked O\nthree O\nto O\nwin O\nhis O\nfourth O\nstraight O\n. O\n\nHe O\nallowed O\na O\nleadoff O\ndouble O\nto O\nDavid B-PER\nSegui I-PER\nin O\nthe O\nsecond O\n, O\nand O\nwon O\nfor O\nthe O\nseventh O\ntime O\nin O\neight O\ndecisions O\n. O\n\nThe O\nright-hander O\nretired O\n14 O\nbatters O\nin O\na O\nrow O\nfrom O\nthe O\nsecond O\ninning O\nthrough O\nthe O\nseventh O\n. O\n\nMike B-PER\nOquist I-PER\nallowed O\none O\nMontreal B-LOC\nhit O\nin O\nthe O\nninth O\n. O\n\nMontreal B-LOC\nlost O\nfor O\nthe O\nninth O\ntime O\nin O\n14 O\ngames O\n. O\n\nIn O\nNew B-LOC\nYork I-LOC\n, O\nMarvin B-PER\nBenard I-PER\n's O\ntwo-run O\nhomer O\nsnapped O\na O\ntie O\nand O\nShawn B-PER\nEstes I-PER\ncame O\none O\nout O\naway O\nfrom O\nhis O\nfirst O\ncomplete O\ngame O\nas O\nthe O\nSan B-ORG\nFrancisco I-ORG\nGiants I-ORG\nbeat O\nthe O\nMets B-ORG\n6-4 O\n. O\n\nBenard B-PER\n, O\nhitting O\n.467 O\n( O\n14-for-30 O\n) O\nagainst O\nthe O\nMets B-ORG\nthis O\nseason O\n, O\nhit O\nhis O\nfirst O\npitch O\nfrom O\nPete B-PER\nHarnisch I-PER\n( O\n8-10 O\n) O\nin O\nthe O\nseventh O\nover O\nthe O\nright-field O\nfence O\nto O\nput O\nthe O\nGiants B-ORG\nup O\n4-2 O\n. O\n\nEstes B-PER\n( O\n3-4 O\n) O\nwas O\nlifted O\nfor O\ncloser O\nRod B-PER\nBeck I-PER\nafter O\nyielding O\na O\nsingle O\nwith O\ntwo O\nout O\nin O\nthe O\nninth O\n. O\n\nBeck B-PER\nallowed O\na O\ntwo-run O\ndouble O\nto O\nAlvaro B-PER\nEspinoza I-PER\n, O\nwho O\ncollected O\na O\ncareer-high O\nfour O\nRBI B-MISC\n, O\nbut O\nstruck O\nout O\nBrent B-PER\nMayne I-PER\nfor O\nhis O\n31st O\nsave O\n. O\n\nThe O\nloss O\nwas O\nthe O\nMets B-ORG\n' O\neighth O\nstraight O\n, O\ntheir O\nlongest O\nslide O\nsince O\nSeptember O\n1993 O\n, O\nand O\ndropped O\nthem O\nto O\n0-4 O\nunder O\nnew O\nmanager O\nBobby B-PER\nValentine I-PER\n. O\n\nIn O\nSt B-LOC\nLouis I-LOC\n, O\nTom B-PER\nPagnozzi I-PER\nhad O\nthree O\nhits O\nand O\nthree O\nRBI B-MISC\nand O\nAlan B-PER\nBenes I-PER\nscattered O\nsix O\nhits O\nover O\nsix-plus O\ninnings O\nas O\nthe O\nCardinals B-ORG\nbeat O\nthe O\nColorado B-ORG\nRockies I-ORG\n7-4 O\n. O\n\nBenes B-PER\n( O\n12-8 O\n) O\nallowed O\nthree O\nruns O\n, O\nwalked O\nthree O\nand O\nstruck O\nout O\nthree O\nfor O\nthe O\nwin O\n. O\n\nSt B-ORG\nLouis I-ORG\ndefeated O\nColorado B-ORG\nfor O\njust O\nthe O\nsecond O\ntime O\nin O\n12 O\nmeetings O\ndating O\nback O\nto O\nlast O\nseason O\n. O\n\nRay B-PER\nLankford I-PER\nwent O\n4-for-5 O\nwith O\na O\npair O\nof O\ndoubles O\nfor O\nthe O\nCardinals B-ORG\n, O\nwho O\nwon O\nfor O\njust O\nthe O\nthird O\ntime O\nin O\n11 O\ngames O\n. O\n\nEric B-PER\nAnthony I-PER\nhit O\na O\npair O\nof O\nsolo O\nhomers O\nfor O\nthe O\nRockies B-ORG\n. O\n\nIn O\nPittsburgh B-LOC\n, O\nSean B-PER\nBerry I-PER\ntied O\na O\ncareer O\nhigh O\nwith O\nsix O\nRBI B-MISC\nand O\nDonne B-PER\nWall I-PER\nfired O\na O\nseven-hitter O\nfor O\nhis O\nfirst O\nmajor-league O\nshutout O\nas O\nthe O\nHouston B-ORG\nAstros I-ORG\nrouted O\nthe O\nPirates B-ORG\n10-0 O\n. O\n\nIt O\nwas O\nthe O\nthird O\ntime O\nBerry B-PER\nhad O\nsix O\nRBI B-MISC\nin O\none O\ngame O\n. O\n\nWall B-PER\n( O\n9-4 O\n) O\nstruck O\nout O\nfour O\nand O\nwalked O\nnone O\nto O\npost O\nhis O\nsecond O\ncomplete O\ngame O\nof O\nthe O\nseason O\nand O\nthird O\nstraight O\nwin O\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nEDBERG B-PER\nREFUSES O\nTO O\nQO O\nQUIETLY O\n. O\n\nRichard B-PER\nFinn I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-30 O\n\nRefusing O\nto O\ngo O\nquietly O\nin O\nthe O\nnight O\n, O\nStefan B-PER\nEdberg I-PER\nextended O\nhis O\nstay O\nat O\nhis O\n14th O\nand O\nlast O\nU.S. B-MISC\nOpen I-MISC\nwhen O\nBernd B-PER\nKarbacher I-PER\n, O\ntrailing O\nand O\nhurting O\n, O\nquit O\nin O\nthe O\nfourth O\nset O\nof O\ntheir O\nsecond-round O\nmatch O\nFriday O\n. O\n\nThe O\n30-year-old O\nEdberg B-PER\n, O\na O\nformer O\ntwo-time O\nOpen B-MISC\nchampion O\n, O\nhad O\nwrestled O\ncontrol O\nof O\nthe O\nmatch O\naway O\nfrom O\nKarbacher B-PER\nwhen O\nthe O\nGerman B-MISC\n, O\nhampered O\nby O\na O\nleft O\nhamstring O\ninjury O\n, O\ndecided O\nhe O\ncould O\nn't O\ncontinue O\nunder O\nthe O\nstadium O\nlights O\nat O\nthe O\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\n. O\n\n\" O\nA O\nwin O\nis O\na O\nwin O\n. O\n\nI O\n'll O\ntake O\nit O\n, O\n\" O\nEdberg B-PER\n, O\nwho O\nhas O\nannounced O\nthat O\nthis O\nwill O\nbe O\nhis O\nlast O\nGrand B-MISC\nSlam I-MISC\nevent O\n, O\nsaid O\nof O\nthe O\n3-6 O\n6-3 O\n6-3 O\n1-0 O\nvictory O\n. O\n\nIronically O\n, O\nKarbacher B-PER\ntwo O\nyears O\nago O\nended O\nIvan B-PER\nLendl I-PER\n's O\nGrand B-MISC\nSlam I-MISC\ncareer O\nhere O\nwhen O\nthe O\nformer O\nchampion O\nhad O\nto O\nretire O\nin O\nthe O\nmiddle O\nof O\ntheir O\nfirst-round O\nmatch O\n. O\n\nAfter O\nseeing O\nthe O\ntrainer O\ncome O\nout O\nearly O\nin O\nthe O\nthird O\nset O\n, O\nEdberg B-PER\nwas O\nnot O\nsurprised O\nby O\nKarbacher B-PER\n's O\ndecision O\nnot O\nto O\ngo O\non O\n. O\n\n\" O\nI O\nknew O\nhe O\nhad O\nproblems O\nwith O\nsomething O\n, O\n\" O\nEdberg B-PER\nsaid O\n. O\n\" O\n\nI O\nreally O\nwas O\nn't O\nsurprised O\n. O\n\" O\n\nEdberg B-PER\nhad O\nhis O\nown O\nproblems O\nearly O\nin O\nthe O\nmatch O\nas O\nthe O\nSwede B-MISC\nbattled O\nto O\nacclimate O\nhimself O\nto O\nthe O\nnighttime O\nconditions O\nwhile O\nKarbacher B-PER\nwas O\nripping O\npassing O\nshots O\nand O\nblasting O\nserves O\npast O\nhim O\n. O\n\n\" O\nI O\ndid O\nn't O\nreally O\nfeel O\ngood O\nto O\nbegin O\nwith O\n, O\nI O\nhad O\nproblems O\nfinding O\nthe O\ntiming O\non O\nthe O\nball O\n, O\nseeing O\nthe O\nball O\n, O\n\" O\nsaid O\nEdberg B-PER\n, O\nwho O\nupset O\nWimbledon B-MISC\nchampion O\nand O\nfifth-seeded O\nRichard B-PER\nKrajicek I-PER\nin O\nthe O\nfirst O\nround O\n. O\n\n\" O\nThis O\nwas O\none O\nof O\nthese O\nmatches O\nwhere O\nI O\ndid O\nn't O\nplay O\nup O\nto O\nmy O\nstandard O\n. O\n\nI O\nhad O\nto O\nfight O\nhard O\n. O\n\" O\n\nEdberg B-PER\n's O\ntenacity O\npaid O\noff O\nin O\nthe O\nsecond O\nset O\n. O\n\nEdberg B-PER\nlost O\nhis O\nown O\nserve O\ntwice O\n, O\nbut O\nhe O\nrallied O\nfor O\nthree O\nbreaks O\nof O\nhis O\nown O\n, O\nthe O\nlast O\nto O\nwrap O\nup O\nthe O\nset O\n. O\n\n\" O\nThat O\n's O\nwhere O\nthe O\nmatch O\nsort O\nof O\nchanged O\n, O\n\" O\nsaid O\nEdberg B-PER\n. O\n\" O\n\nI O\nthink O\nonce O\nI O\ngot O\nthat O\nsecond O\nset O\n, O\nI O\nfelt O\na O\nlot O\nbetter O\nabout O\nmy O\ngame O\n. O\n\" O\n\nEdberg B-PER\nis O\nstarting O\nto O\nfeel O\npretty O\ngood O\nabout O\npostponing O\nhis O\nswan O\nsong O\na O\nlot O\nlonger O\n. O\n\n\" O\nIt O\ndoes O\nn't O\nlook O\nall O\nthat O\nbad O\n, O\n\" O\nEdberg B-PER\nsaid O\nof O\nhis O\npath O\nthrough O\nthe O\ndraw O\nstarting O\nnext O\nwith O\na O\nmatch O\nagainst O\nKrajicek B-PER\n's O\nDutch B-MISC\ncountryman O\nPaul B-PER\nHaarhuis I-PER\n. O\n\nHowever O\n, O\nthe O\n1991 O\nand O\n1992 O\nchampion O\nis O\nnot O\nready O\nto O\nstart O\nmaking O\nplans O\nto O\nbe O\nin O\nnext O\nweek O\n's O\nfinal O\n. O\n\n\" O\nI O\n'm O\nalways O\nbeing O\nrealistic O\n, O\n\" O\nsaid O\nEdberg B-PER\n. O\n\" O\n\nLike O\nI O\nsaid O\nmany O\ntimes O\n, O\nI O\nthink O\nit O\n's O\na O\nvery O\nlittle O\nchance O\n, O\nbut O\nnothing O\nis O\nimpossible O\n. O\n\nIf O\nI O\nplay O\ngreat O\ntennis O\n, O\nthat O\ncould O\ntake O\nme O\na O\nlong O\nway O\n. O\n\n\" O\nA O\nlot O\nof O\nthings O\ncan O\nhappen O\n, O\nlike O\ntonight O\n. O\n\" O\n\n-DOCSTART- O\n\nBOXING O\n- O\nPRINCE O\nNASEEM B-PER\nRETAINS O\nWBO O\nFEATHERWEIGHT O\nTITLE O\n. O\n\nDUBLIN B-LOC\n1996-08-31 O\n\nBritain B-LOC\n's O\nNaseem B-PER\nHamed I-PER\nretained O\nhis O\nWBO B-ORG\nfeatherweight O\ntitle O\non O\nSaturday O\nwhen O\nMexico B-LOC\n's O\nManuel B-PER\nMedina I-PER\nwas O\nretired O\nby O\nhis O\ncorner O\nat O\nthe O\nend O\nof O\nthe O\n11th O\nround O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nAUSTRIA B-LOC\nDOMINATE O\nSCOTLAND B-LOC\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nSteve B-PER\nPagani I-PER\n\nVIENNA B-LOC\n1996-08-31 O\n\nAustria B-LOC\ndominated O\ntheir O\nWorld B-MISC\nCup I-MISC\ngroup O\nfour O\nqualifier O\nagainst O\nScotland B-LOC\non O\nSaturday O\nwith O\nwave O\nafter O\nwave O\nof O\nattacks O\nbut O\nwere O\nunable O\nto O\npenetrate O\nthe O\nvisitors O\n' O\ndefence O\nand O\nhad O\nto O\nsettle O\nfor O\na O\ngoalless O\ndraw O\n. O\n\nScotland B-LOC\n, O\nwho O\nthrashed O\nBelarus B-LOC\n5-1 O\nin O\ntheir O\nopening O\ngroup O\nfour O\nmatch O\n, O\nwere O\nunable O\nto O\nrepeat O\ntheir O\nperformance O\n. O\n\nAustria B-LOC\n's O\nbest O\nchance O\ncame O\nin O\nthe O\n63rd O\nminute O\nwith O\nStephan B-PER\nMarasek I-PER\nof O\nSC B-ORG\nFreiburg I-ORG\ntaking O\nadvantage O\nof O\na O\nscramble O\nin O\nthe O\nScottish B-MISC\npenalty O\narea O\nbut O\nhis O\nshot O\nnarrowly O\npassing O\nthe O\nleft-hand O\npost O\n. O\n\nThey O\nalso O\nwent O\nclose O\na O\nminute O\nbefore O\nthe O\ninterval O\nwhen O\na O\npromising O\nattack O\nsaw O\nthe O\nball O\nfall O\nto O\nMarkus B-PER\nSchopp I-PER\nbut O\nhe O\nhit O\nhis O\nshot O\nwide O\n. O\n\nEverton B-ORG\n's O\nDuncan B-PER\nFerguson I-PER\nwent O\nclose O\nfor O\nScotland B-LOC\nin O\nthe O\n65th O\nminute O\nwhen O\nhe O\nforced O\nAustrian B-MISC\ngoalkeeper O\nMichael B-PER\nKonsel I-PER\nto O\na O\ndiving O\nsave O\n. O\n\nTwo O\nScotland B-LOC\nplayers O\nwere O\nshown O\nyellow O\ncards O\n, O\ncaptain O\nGary B-PER\nMcAllister I-PER\nfor O\nbringing O\ndown O\nAndreas B-PER\nHeraf I-PER\nand O\nFerguson B-PER\nfor O\narguing O\nagainst O\nthe O\nreferee O\n's O\ndecision O\n. O\n\n\" O\nThe O\nresult O\nis O\nacceptable O\n, O\n\" O\nScottish B-MISC\ncoach O\nCraig B-PER\nBrown I-PER\ntold O\nreporters O\n. O\n\" O\n\nWe O\n'd O\nhoped O\nnot O\nto O\nlose O\nand O\nwe O\ntried O\nnot O\nto O\nplay O\nfor O\na O\ndraw O\nbut O\nthe O\nAustrian B-MISC\ndefence O\nwas O\nsimply O\ntoo O\ngood O\n. O\n\" O\n\nSK B-ORG\nRapid I-ORG\n's O\nDietmar B-PER\nKuehbauer I-PER\n, O\nwho O\ngave O\nan O\nimpressive O\nperformance O\n, O\nsaid O\nthe O\nteam O\nstarted O\noff O\nwell O\nbut O\nlet O\nthe O\ngame O\nslip O\nafter O\nthe O\nfirst O\n30 O\nminutes O\n. O\n\n\" O\nSomehow O\nit O\nseemed O\nthere O\nwere O\nless O\nthan O\n11 O\nplayers O\non O\nthe O\npitch O\n. O\n\nWe O\nhave O\nlost O\ntwo O\npoints O\n. O\n\nThe O\nScots O\nare O\nnot O\nreally O\na O\ngreat O\nteam O\nand O\nwe O\nshould O\nhave O\nwon O\n, O\n\" O\nhe O\nsaid O\n. O\n\nAustrian B-MISC\ncoach O\nHerbert B-PER\nProhaska I-PER\nsaid O\nhis O\nteam O\nhad O\ndisplayed O\ngreat O\nfighting O\nspirit O\nbut O\nsometimes O\nlacked O\nideas O\n. O\n\nTeams O\n: O\n\nAustria B-LOC\n: O\nMichael B-PER\nKonsel I-PER\n, O\nMarkus B-PER\nSchopp I-PER\n, O\nPeter B-PER\nSchoettel I-PER\n, O\nAnton B-PER\nPfeffer I-PER\n, O\nWolfgang B-PER\nFeiersinger I-PER\n, O\nStephan B-PER\nMarasek I-PER\n, O\nDieter B-PER\nRamusch I-PER\n( O\nAndreas B-PER\nOgris I-PER\n77th O\n) O\n, O\nDietmar B-PER\nKuehbauer I-PER\n, O\nAnton B-PER\nPolster I-PER\n( O\n( O\nHerfried B-PER\nSabitzer I-PER\n68th O\n) O\n, O\nAndreas B-PER\nHerzog I-PER\n, O\nAndreas B-PER\nHeraf I-PER\n. O\n\nScotland B-LOC\n: O\nAndrew B-PER\nGoram I-PER\n, O\nCraig B-PER\nBurley I-PER\n, O\nThomas B-PER\nBoyd I-PER\n, O\nColin B-PER\nCalderwood I-PER\n, O\nColin B-PER\nHendry I-PER\n, O\nThomas B-PER\nMcKinley I-PER\n, O\nDuncan B-PER\nFerguson I-PER\n, O\nStuart B-PER\nMcCall I-PER\n, O\nAlistair B-PER\nMcCoist I-PER\n( O\nGordon B-PER\nDurie I-PER\n75th O\n) O\n, O\nGary B-PER\nMcAllister I-PER\n, O\nJohn B-PER\nCollins I-PER\n. O\n\n-DOCSTART- O\n\nBOXING O\n- O\nJOHNSON B-PER\nWINS O\nUNANIMOUS O\nPOIUNTS O\nVERDICT O\n. O\n\nDUBLIN B-LOC\n1996-08-31 O\n\nAmerican B-MISC\nTom B-PER\nJohnson I-PER\nsuccessfully O\ndefended O\nhis O\nIBF B-ORG\nfeatherweight O\ntitle O\nwhen O\nhe O\nearned O\na O\nunanimous O\npoints O\ndecision O\nover O\nVenezuela B-LOC\n's O\nRamon B-PER\nGuzman I-PER\non O\nSaturday O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRANCE B-LOC\nLAUNCH O\n1998 O\nWORLD B-MISC\nCUP I-MISC\nBUILD-UP O\nWITH O\n2-0 O\nWIN O\n. O\n\nPARIS B-LOC\n1996-08-31 O\n\nEuro B-MISC\n96 I-MISC\nabsentee O\nNicolas B-PER\nOuedec I-PER\nand O\nYouri B-PER\nDjorkaeff I-PER\nscored O\nthe O\ngoals O\nas O\n1998 O\nWorld B-MISC\nCup I-MISC\nhosts O\nFrance B-LOC\nbeat O\nMexico B-LOC\n2-0 O\nin O\na O\nfriendly O\ninternational O\non O\nSaturday O\n. O\n\nThe O\nvictory O\nextended O\nto O\n29 O\nmatches O\nFrance B-LOC\n's O\nunbeaten O\nrun O\nunder O\ncoach O\nAime B-PER\nJacquet I-PER\n, O\ntheir O\nEuro B-MISC\n96 I-MISC\nsemifinal O\nelimination O\nhaving O\ncome O\nin O\na O\npenalty O\nshoot-out O\n, O\nbut O\nwas O\nmarred O\nby O\nthe O\nsending-off O\nof O\nChelsea B-ORG\ncentral O\ndefender O\nFranck B-PER\nLeboeuf I-PER\n. O\n\nLeboeuf B-PER\nwas O\ndismissed O\ntwo O\nminutes O\nfrom O\ntime O\nfor O\na O\nsecond O\nbookable O\noffence O\n, O\nfouling O\nMexican B-MISC\nsubstitute O\nRicardo B-PER\nPelaez I-PER\nwho O\nminutes O\nearlier O\nhad O\nalso O\nbeen O\nshown O\nthe O\nyellow O\ncard O\nfor O\npushing O\nthe O\nChelsea B-ORG\ndefender O\nin O\nthe O\nback O\n. O\n\nBoth O\ngoals O\ncame O\nearly O\nin O\nthe O\nsecond O\nhalf O\nafter O\nFrance B-LOC\nhad O\nsurprised O\nthe O\nMexicans B-MISC\nwith O\nthree O\nhalf-time O\nsubstitutions O\n. O\n\nAfter O\na O\nsterile O\nfirst O\nhalf O\n, O\nFrance B-LOC\ninjected O\nmore O\nsting O\nin O\nmidfield O\nwith O\nthe O\nintroduction O\nof O\nJuventus B-ORG\n's O\nZinedine B-PER\nZidane I-PER\n. O\n\nThis O\nallowed O\nDjorkaeff B-PER\nto O\nplay O\nfurther O\nup O\nand O\nhis O\ncross O\nfrom O\nthe O\nright O\nfell O\nfor O\nOuedec B-PER\n, O\nwho O\nhas O\njoined O\nEspanyol B-ORG\nof O\nBarcelona B-LOC\nfrom O\nNantes B-ORG\nsince O\nmissing O\nthe O\nEuropean B-MISC\nchampionship O\nfinals O\nthrough O\ninjury O\n, O\nto O\nscore O\nafter O\na O\nmistake O\nby O\nmidfielder O\nJoaquin B-PER\ndel I-PER\nOlmo I-PER\n. O\n\nWithin O\nfour O\nminutes O\nOuedec B-PER\nwas O\nreturning O\nthe O\ncompliment O\nfor O\nDjorkaeff B-PER\n, O\nplaying O\na O\none-two O\nwith O\nthe O\nInternazionale B-ORG\nMilan I-ORG\nforward O\ndown O\nthe O\nmiddle O\nto O\nset O\nhim O\nup O\nfor O\na O\ncross O\nshot O\npast O\ndiving O\ngoalkeeper O\nOsvaldo B-PER\nSanchez I-PER\n. O\n\nJacquet B-PER\n, O\nbeginning O\nthe O\n22-month O\ncountdown O\nto O\nFrance B-LOC\n's O\nhosting O\nof O\nthe O\nWorld B-MISC\nCup I-MISC\nfinals O\n, O\nsaid O\n: O\n\" O\nWe O\nhave O\nan O\nidentity O\n( O\nas O\na O\nteam O\n) O\nwhich O\nwe O\nare O\ngoing O\nto O\nwork O\non O\n. O\n\" O\n\nTeams O\n: O\n\nFrance B-LOC\n- O\n1 O\n- O\nBernard B-PER\nLama I-PER\n; O\n2 O\n- O\nLilian B-PER\nThuram I-PER\n( O\n14 O\n- O\nSabri B-PER\nLamouchi I-PER\n87th O\n) O\n, O\n5 O\n- O\nLaurent B-PER\nBlanc I-PER\n, O\n8 O\n- O\nMarcel B-PER\nDesailly I-PER\n( O\n12 O\n- O\nFranck B-PER\nLeboeuf I-PER\n46th O\n) O\n, O\n3 O\n- O\nBixente B-PER\nLizarazu I-PER\n; O\n4 O\n- O\nChristian B-PER\nKarembeu I-PER\n, O\n7 O\n- O\nDidier B-PER\nDeschamps I-PER\n, O\n10 O\n- O\nYouri B-PER\nDjorkaeff I-PER\n, O\n6 O\n- O\nReynald B-PER\nPedros I-PER\n( O\n13 O\n- O\nRobert B-PER\nPires I-PER\n46th O\n) O\n; O\n9 O\n- O\nNicolas B-PER\nOuedec I-PER\n( O\n17 O\n- O\nFlorian B-PER\nMaurice I-PER\n64th O\n) O\n, O\n11 O\n- O\nPatrice B-PER\nLoko I-PER\n( O\n15 O\n- O\nZinedine B-PER\nZidane I-PER\n46th O\n) O\n\nMexico B-LOC\n- O\n1 O\n- O\nOsvaldo B-PER\nSanchez I-PER\n( O\n12 O\n- O\nAlfonso B-PER\nRios I-PER\n78th O\n) O\n; O\n13 O\n- O\nPavel B-PER\nPardo I-PER\n, O\n2 O\n- O\nClaudio B-PER\nSuarez I-PER\n, O\n5 O\n- O\nDuilio B-PER\nDavino I-PER\n( O\nBecerril B-PER\n46th O\n) O\n, O\n4 O\n- O\nGerman B-PER\nVilla I-PER\n( O\n16 O\n- O\nGomez B-PER\n86th O\n) O\n; O\n14 O\n- O\nJoaquin B-PER\ndel I-PER\nOlmo I-PER\n, O\n6 O\n- O\nRaul B-PER\nRodrigo I-PER\nLara I-PER\n( O\n11 O\n- O\nCuauhtemoc B-PER\nBlanco I-PER\n65th O\n) O\n, O\n8 O\n- O\nAlberto B-PER\nGarcia I-PER\nAspe I-PER\n, O\n7 O\n- O\nRamon B-PER\nRamirez I-PER\n( O\n15 O\n- O\nJesus B-PER\nArellano I-PER\n71st O\n) O\n; O\n18 O\n- O\nEnrique B-PER\nAlfaro I-PER\n( O\n17 O\n- O\nFrancisco B-PER\nPalencia I-PER\n78th O\n) O\n, O\n10 O\n- O\nLuis B-PER\nGarcia I-PER\n( O\n19 O\n- O\nRicardo B-PER\nPelaez I-PER\n69th O\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRANCE B-LOC\nBEAT O\nMEXICO B-LOC\n2-0 O\nIN O\nFRIENDLY O\n. O\n\nPARIS B-LOC\n1996-08-31 O\n\nFrance B-LOC\nbeat O\nMexico B-LOC\n2-0 O\n( O\nhalftime O\n0-0 O\n) O\nin O\na O\nfriendly O\nsoccer O\ninternational O\non O\nSaturday O\n. O\n\nScorers O\n: O\nNicolas B-PER\nOuedec I-PER\n( O\n49th O\nminute O\n) O\n, O\nYouri B-PER\nDjorkaeff I-PER\n( O\n53rd O\n) O\n\nAttendance O\n: O\n18,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBELGIUM B-LOC\nSCRAPE O\nPAST O\nTURKEY B-LOC\nDESPITE O\nCROWD O\nTROUBLE O\n. O\n\nBert B-PER\nLauwers I-PER\n\nBRUSSELS B-LOC\n1996-08-31 O\n\nBelgium B-LOC\nkicked O\noff O\ntheir O\n1998 B-MISC\nWorld I-MISC\nCup I-MISC\ncampaign O\nwith O\na O\nhard-fought O\n2-1 O\nvictory O\nover O\n10-man O\nTurkey B-LOC\nin O\na O\ntense O\nmatch O\nmarred O\nby O\nTurkish B-MISC\ncrowd O\ntrouble O\nshortly O\nafter O\nthe O\nbreak O\n. O\n\nTurkish B-MISC\nfans O\n, O\nupset O\nat O\ntheir O\nteam O\n's O\n2-0 O\nfirst-half O\ndeficit O\n, O\nripped O\napart O\ndozens O\nof O\nplastic O\nseats O\nand O\nthrew O\nthem O\nover O\nthe O\nfence O\n. O\n\nRiot O\npolice O\ntook O\n10 O\nminutes O\nto O\nrestore O\norder O\n. O\n\nThe O\npolice O\nwere O\ngiven O\nan O\nunexpected O\nhand O\nby O\nsecond-half O\nsubstitute O\nSergen B-PER\nYalcin I-PER\nwho O\nrekindled O\nTurkish B-MISC\nhopes O\nin O\nthe O\n61st O\nwith O\na O\nsplendid O\nhalf-volley O\nwhich O\nstunned O\nBelgian B-MISC\ngoalkeeper O\nFilip B-PER\nDe I-PER\nWilde I-PER\n. O\n\nBut O\nYalcin B-PER\n, O\nwho O\nhad O\ncome O\non O\njust O\nfour O\nminutes O\nearlier O\n, O\nturned O\nfrom O\nhero O\nto O\nvillain O\nbarely O\ntwo O\nminutes O\nafter O\nhis O\nstrike O\nwhen O\nhe O\nwas O\nsent O\noff O\nafter O\nspitting O\nat O\nan O\nopponent O\nand O\narguing O\nwith O\nEnglish B-MISC\nreferee O\nDavid B-PER\nElleray I-PER\n. O\n\nMarc B-PER\nDegryse I-PER\nhad O\nopened O\nthe O\nscoring O\nfor O\nBelgium B-LOC\nafter O\n13 O\nminutes O\n, O\nwhacking O\na O\nlow O\n10-metre O\ndrive O\ninto O\nthe O\nnet O\nafter O\nan O\nincisive O\npass O\nby O\ndefender O\nDirk B-PER\nMedved I-PER\nfrom O\nthe O\nedge O\nof O\nthe O\npenalty O\narea O\n. O\n\nBrazilian-born O\nLuis B-PER\nOliveira I-PER\nthen O\ngleefully O\nslipped O\nthe O\nball O\npast O\ngoalkeeper O\nRustu B-PER\nRecber I-PER\nfrom O\nthe O\nright O\nof O\nthe O\narea O\nto O\nmake O\nit O\n2-0 O\nseven O\nminutes O\nbefore O\nthe O\ninterval O\n, O\nTurkey B-LOC\n's O\nbest O\nfirst-half O\neffort O\nproving O\nto O\nbe O\na O\nvicious O\n30-metre O\nshot O\nby O\nOgun B-PER\nTemizkanoglu I-PER\nwhich O\nDe B-PER\nWilde I-PER\ntipped O\nover O\n. O\n\nThe O\nvisitors O\n, O\nseeking O\nto O\nrestore O\nsome O\npride O\nafter O\nfailing O\nto O\nscore O\na O\nsingle O\ngoal O\nin O\nEuro B-MISC\n96 I-MISC\nin O\nJune O\n, O\nrepeatedly O\nripped O\nthrough O\nthe O\nleft O\nside O\nof O\nthe O\nhome O\ndefence O\nbut O\nDe B-PER\nWilde I-PER\nwas O\nable O\nto O\nblock O\nseveral O\nsharply-angled O\nefforts O\n. O\n\nWith O\nonly O\nthe O\ngroup O\nseven O\nwinners O\nqualifying O\nautomatically O\nfor O\nthe O\n1998 O\nfinals O\nin O\nFrance B-LOC\n, O\nBelgium B-LOC\ncould O\nnot O\nafford O\na O\nslip-up O\nat O\nhome O\nand O\nthey O\nfrantically O\nchased O\na O\ndecisive O\nthird O\ngoal O\n. O\n\nBut O\nthey O\nwere O\nalmost O\nupset O\n12 O\nminutes O\nfrom O\ntime O\nwhen O\nDe B-PER\nWilde I-PER\nfumbled O\na O\nhard O\nArif B-PER\nErdem I-PER\nshot O\nand O\nOrhan B-PER\nCikirikci I-PER\nalmost O\npounced O\non O\nthe O\nloose O\nball O\n. O\n\nBelgium B-LOC\n's O\nbest O\nsecond-half O\neffort O\ncame O\nthree O\nminutes O\nlater O\nwhen O\nDegryse B-PER\nput O\nthe O\nball O\nover O\nthe O\nbar O\nfrom O\nclose O\nrange O\nwith O\nRecber B-PER\nbeaten O\n. O\n\nTeams O\n: O\n\nBelgium B-LOC\n- O\n1 O\n- O\nFilip B-PER\nDe I-PER\nWilde I-PER\n, O\n2 O\n- O\nBertrand B-PER\nCrasson I-PER\n, O\n3 O\n- O\nDirk B-PER\nMedved I-PER\n, O\n4 O\n- O\nPascal B-PER\nRenier I-PER\n, O\n16 O\n- O\nGeoffrey B-PER\nClaeys I-PER\n, O\n6 O\n- O\nGunther B-PER\nSchepens I-PER\n( O\n15 O\n- O\nNico B-PER\nVan I-PER\nKerckhoven I-PER\n, O\n81st O\n) O\n, O\n10 O\n- O\nEnzo B-PER\nScifo I-PER\n, O\n7 O\n- O\nGert B-PER\nVerheyen I-PER\n( O\n14 O\n- O\nFrederic B-PER\nPeiremans I-PER\n, O\n62nd O\n) O\n, O\n9 O\n- O\nMarc B-PER\nDegryse I-PER\n, O\n8 O\n- O\nLuc B-PER\nNilis I-PER\n, O\n11- O\nLuis B-PER\nOliveira I-PER\n( O\n18 O\n- O\nGilles B-PER\nDe I-PER\nBilde I-PER\n, O\n88th O\n) O\n. O\n\nTurkey B-LOC\n- O\n1 O\n- O\nRustu B-PER\nRecber I-PER\n, O\n4 O\n- O\nHakan B-PER\nUnsal I-PER\n( O\n14 O\n- O\nSergen B-PER\nYalcin I-PER\n, O\n57th O\n) O\n, O\n2 O\n- O\nRecep B-PER\nCetin I-PER\n, O\n3 O\n- O\nOgun B-PER\nTemizkanoglu I-PER\n, O\n5 O\n- O\nAlpay B-PER\nOzalan I-PER\n, O\n7- O\nAbdullah B-PER\nErcan I-PER\n, O\n6 O\n- O\nTolunay B-PER\nKafkas I-PER\n, O\n10 O\n- O\nOguz B-PER\nCetin I-PER\n( O\n13 O\n- O\nArif B-PER\nErdem I-PER\n, O\n57th O\n) O\n, O\n11 O\n- O\nTayfun B-PER\nKorkut I-PER\n, O\n9 O\n- O\nHakan B-PER\nSukur I-PER\n, O\n8 O\n- O\nSaffet B-PER\nSancakli I-PER\n( O\n17- O\nOrhan B-PER\nCikirikci I-PER\n, O\n76th O\n) O\n. O\n\nBelgian B-MISC\ncoach O\nWilfried B-PER\nVan I-PER\nMoer I-PER\nsaid O\nhe O\nhad O\nnot O\nexpected O\nTurkey B-LOC\nto O\nbe O\nso O\nstrong O\nand O\nfast O\n. O\n\n\" O\nWe O\nstarted O\npanicking O\na O\nbit O\nafter O\nthe O\nTurkish B-MISC\ngoal O\n... O\n\nwe O\nsuffered O\n, O\n\" O\nsaid O\nVan B-PER\nMoer I-PER\n, O\nwho O\nsucceeded O\nPaul B-PER\nVan I-PER\nHimst I-PER\nas O\ncoach O\nin O\nApril O\n. O\n\nIt O\nwas O\nBelgium B-LOC\n's O\nfirst O\nvictory O\nunder O\nVan B-PER\nMoer I-PER\nafter O\ntwo O\ndraws O\nin O\nfriendlies O\nagainst O\nRussia B-LOC\nand O\nItaly B-LOC\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSUMMARY O\nIN O\nTHE O\nSPANISH B-MISC\nFIRST O\nDIVISION O\n. O\n\nMADRID B-LOC\n1996-08-30 O\n\nSummary O\nof O\ngame O\nplayed O\nin O\nthe O\nSpanish B-MISC\nfirst O\ndivision B-MISC\non O\nSaturday O\n: O\nDeportivo B-ORG\nCoruna I-ORG\n1 O\n( O\nCorentine B-PER\nMartins I-PER\n, O\n22nd O\nminute O\n) O\nReal B-ORG\nMadrid I-ORG\n1 O\n( O\nRoberto B-PER\nCarlos I-PER\n79th O\n) O\n. O\n\nHalftime O\n1-0 O\n. O\n\nAttendancce O\n35,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nRESULT O\nIN O\nSPANISH B-MISC\nFIRST O\nDIVISION O\n. O\n\nMADRID B-LOC\n1996-08-31 O\n\nResult O\nof O\ngame O\nplayed O\nin O\nthe O\n\nSpanish B-MISC\nfirst O\ndivision B-MISC\non O\nSaturday O\n: O\n\nDeportivo B-ORG\nCoruna I-ORG\n1 O\nReal B-ORG\nMadrid I-ORG\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBELGIUM B-LOC\nBEAT O\nTURKEY B-LOC\n2-1 O\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nBRUSSELS B-LOC\n1996-08-31 O\n\nBelgium B-LOC\nbeat O\nTurkey B-LOC\n2-1 O\n\n( O\nhalftime O\n2-0 O\n) O\nin O\na O\nWorld B-MISC\nCup I-MISC\ngroup O\nseven O\nsoccer O\nqualifier O\non O\n\nSaturday O\n: O\n\nScorers O\n: O\n\nBelgium B-LOC\n- O\nMarc B-PER\nDegryse I-PER\n( O\n13th O\n) O\n, O\nLuis B-PER\nOliveira I-PER\n( O\n38th O\n) O\n\nTurkey B-LOC\n- O\nSergen B-PER\nYalcin I-PER\n( O\n61st O\n) O\n\nAttendance O\n: O\n30,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nAUSTRIA B-LOC\nDRAW O\n0-0 O\nWITH O\nSCOTLAND B-LOC\nIN O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nVIENNA B-LOC\n1996-08-31 O\n\nAustria B-LOC\nand O\nScotland B-LOC\ndrew O\n0-0 O\nin O\na O\nWorld B-MISC\nCup I-MISC\nsoccer O\nEuropean B-MISC\ngroup O\nfour O\nqualifier O\non O\nSaturday O\n. O\n\nAttendance O\n: O\n29,500 O\n\n-DOCSTART- O\n\nBOXING O\n- O\nKNOCK-OUT O\nSPECIALIST O\nMILLER B-PER\nDEFENDS O\nTITLE O\n. O\n\nDUBLIN B-LOC\n1996-08-31 O\n\nA O\npowerful O\nright O\nhook O\nfollowed O\nby O\na O\nstraight O\nleft O\ngave O\ndefending O\nchampion O\nNate B-PER\nMiller I-PER\na O\nseventh O\nround O\nknock-out O\nwin O\nover O\nfellow O\nAmerican B-MISC\nJames B-PER\nHeath I-PER\nin O\ntheir O\nWBA B-ORG\ncruiserweight O\ntitle O\nbout O\non O\nSaturday O\n. O\n\nMiller B-PER\n, O\nwho O\nwent O\ninto O\nthe O\ncontest O\nwith O\na O\nrecord O\nof O\n24 O\nknock-out O\nwins O\nin O\n32 O\nfights O\n, O\ntook O\ncharge O\nfrom O\nthe O\nopening O\nbell O\nand O\nhad O\nhis O\nopponent O\non O\nthe O\ncanvas O\ninside O\n90 O\nseconds O\nwhen O\nhe O\nlanded O\na O\ndeft O\nleft-hook O\nto O\nthe O\nhead O\n. O\n\nHeath B-PER\ndid O\nscore O\nwith O\ntwo O\nbrusing O\nlefts O\nto O\nMiller B-PER\n's O\nhead O\nin O\nthe O\nthird O\nround O\nbut O\nfailed O\nto O\nput O\nhis O\nopponent O\nunder O\nany O\nreal O\npressure O\n. O\n\nMiller B-PER\nraised O\nthe O\npace O\nof O\nthe O\ncontest O\nat O\nthe O\nstart O\nof O\nthe O\nfifth O\nround O\nand O\n, O\nonce O\nhe O\nstarted O\nto O\nget O\nhis O\nright-left O\ncombinations O\nworking O\nfor O\nhim O\n, O\nthe O\nfight O\nwas O\nnever O\nlikely O\nto O\ngo O\nthe O\ndistance O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nDRAW O\n2-2 O\nWITH O\nBRAZIL B-LOC\nIN O\nFRIENDLY O\nINTERNATIONAL O\n. O\n\nAMSTERDAM B-LOC\n1996-08-31 O\n\nThe B-LOC\nNetherlands I-LOC\ndrew O\n2-2 O\nwith O\n\nBrazil B-LOC\n( O\nhalf-time O\n0-1 O\n) O\nin O\na O\nsoccer O\nfriendly O\non O\nSaturday O\n. O\n\nScorers O\n: O\n\nNetherlands B-LOC\n- O\nRonald B-PER\nde I-PER\nBoer I-PER\n( O\n52nd O\nminute O\n) O\n, O\nVan B-PER\nGastel I-PER\n\n( O\n90th O\n, O\npen O\n) O\n\nBrazil B-LOC\n- O\nGiovanni B-PER\n( O\n14th O\n) O\n, O\nMarcello B-PER\nGoncalves I-PER\n( O\n55th O\n) O\n\n-DOCSTART- O\n\nBOXING O\n- O\nMILLER B-PER\nDEFENDS O\nWBA B-ORG\nCRUISERWEIGHT O\nTITLE O\n. O\n\nDUBLIN B-LOC\n1996-08-31 O\n\nAmerican B-MISC\nNate B-PER\nMiller I-PER\nsuccessfully O\ndefended O\nhis O\nWBA B-ORG\ncruiserweight O\ntitle O\nwhen O\nhe O\nknocked O\nout O\ncompatriot O\nJames B-PER\nHeath I-PER\nin O\nthe O\nseventh O\nround O\nof O\ntheir O\nbout O\non O\nSaturday O\n. O\n\n-DOCSTART- O\n\nHORSE O\nRACING O\n- O\nTATTERSALLS B-MISC\nBREEDERS I-MISC\nSTAKES O\nRESULT O\n. O\n\nDUBLIN B-LOC\n1996-08-31 O\n\nResult O\nof O\nthe O\nTattersalls B-MISC\nBreeders I-MISC\n\nStakes B-MISC\n, O\na O\nrace O\nfor O\ntwo-year-olds O\nrun O\nover O\nsix O\nfurlongs O\n( O\n1,200 O\n\nmetres O\n) O\nat O\nThe B-LOC\nCurragh I-LOC\non O\nSaturday O\n: O\n\n1. O\nMiss B-PER\nStamper I-PER\n3-1 O\njoint-favourite O\n( O\nridden O\nby O\nDavid B-PER\nHarrison I-PER\n) O\n\n2. O\nPaddy B-PER\nLad I-PER\n16-1 O\n( O\nPeter B-PER\nBloomfield I-PER\n) O\n\n3. O\nPelham B-PER\n10-1 O\n( O\nWarren B-PER\nO'Connor I-PER\n) O\n\nDistances O\n: O\nThree O\nlengths O\n, O\ntwo-and-a-half O\nlengths O\n. O\n\nWinner O\nowned O\nby O\nJohn B-PER\nand O\nBeryll B-PER\nRemblance I-PER\nand O\ntrained O\nin O\n\nBritain B-LOC\nby O\nRichard B-PER\nHannon I-PER\n. O\n\nValue O\nto O\nthe O\nwinning O\nowner O\n: O\n$ O\n233,600 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nKLINSMANN B-PER\nTO O\nRETIRE O\nAFTER O\n1998 B-MISC\nWORLD I-MISC\nCUP I-MISC\n. O\n\nBONN B-LOC\n1996-08-31 O\n\nGerman B-MISC\ninternational O\nstriker O\nJuergen B-PER\nKlinsmann I-PER\nhas O\nsaid O\nhe O\nwill O\nretire O\nafter O\nthe O\n1998 O\nWorld B-MISC\nCup I-MISC\nin O\nFrance B-LOC\n. O\n\n\" O\nFor O\nmyself O\n, O\npersonally O\n, O\nI O\n've O\nplanned O\nthings O\nso O\nthat O\nthat O\nwill O\nbe O\nthe O\nend O\nof O\nme O\n, O\n\" O\nthe O\n32-year-old O\nnational O\nteam O\ncaptain O\nwas O\nquoted O\nas O\nsaying O\nby O\nthe O\ndaily O\nSueddeutsche B-ORG\nZeitung I-ORG\non O\nSaturday O\n. O\n\nKlinsmann B-PER\nsaid O\nhe O\nbelieved O\nGermany B-LOC\ncould O\nwin O\nin O\nFrance B-LOC\nwith O\nthe O\nsame O\nnucleus O\nof O\nplayers O\nwhich O\nwon O\nthe O\nEuropean B-MISC\nchampionship O\nin O\nEngland B-LOC\nthis O\nsummer O\n. O\n\n\" O\nI O\nthink O\nit O\ncan O\nbe O\ndone O\n, O\n\" O\nhe O\nsaid O\n, O\n\" O\nespecially O\nas O\nexperience O\nis O\nbecoming O\nmore O\nand O\nmore O\nvaluable O\nin O\nsport O\n. O\n\nI O\nthink O\nwe O\ncan O\ndo O\nit O\nwith O\nthe O\nsame O\nbody O\nof O\nplayers O\n. O\n\nThat O\n's O\nwhat O\nwe O\n're O\nall O\naiming O\nfor O\n. O\n\" O\n\nCoach O\nBerti B-PER\nVogts I-PER\nhas O\ncalled O\nup O\na O\nvirtually O\nidentical O\nsquad O\nfor O\nnext O\nweek O\n's O\nfriendly O\nagainst O\nPoland B-LOC\n-- O\nGermany B-LOC\n's O\nfirst O\nmatch O\nsince O\nEuro B-MISC\n96 I-MISC\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGERMAN B-MISC\nCUP I-MISC\nSECOND O\nROUND O\nRESULTS O\n. O\n\nBONN B-LOC\n1996-08-31 O\n\nResults O\nof O\nGerman B-MISC\nCup I-MISC\nsecond O\nround O\n\nmatches O\non O\nSaturday O\n: O\n\nKarlsruhe B-ORG\n2 O\nHansa B-ORG\nRostock I-ORG\n0 O\n\nBorussia B-ORG\nNeunkirchen I-ORG\n1 O\nSt B-ORG\nPauli I-ORG\n3 O\n\nDuisburg B-ORG\n1 O\nLuebeck B-ORG\n0 O\n( O\nafter O\nextra O\ntime O\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nROMANIA B-LOC\nBEAT O\nLITHUANIA B-LOC\nIN O\nU-21 O\nQUALIFIER O\n. O\n\nBUCHAREST B-LOC\n1996-08-30 O\n\nRomania B-LOC\nbeat O\n2-1 O\n( O\nhalftime O\n1-1 O\n) O\nLithuania B-LOC\nin O\ntheir O\nEuropean B-MISC\nUnder-21 O\nsoccer O\nmatch O\non O\nFriday O\n. O\n\nScorers O\n: O\n\nRomania B-LOC\n- O\nCosmin B-PER\nContra I-PER\n( O\n31st O\n) O\n, O\nMihai B-PER\nTararache I-PER\n( O\n75th O\n) O\n\nLithuania B-LOC\n- O\nDanius B-PER\nGleveckas I-PER\n( O\n13rd O\n) O\n\nAttendence O\n: O\n200 O\n\n-DOCSTART- O\n\nPaper O\nsays O\nThatcher B-PER\n's O\noffice O\nconsulted O\nastrologer O\n. O\n\nLONDON B-LOC\n1996-09-01 O\n\nA O\nBritish B-MISC\nnewspaper O\nsaid O\nMargaret B-PER\nThatcher I-PER\nwas O\nso O\nshaken O\nby O\nan O\nIRA B-ORG\nattempt O\non O\nher O\nlife O\nwhen O\nshe O\nwas O\nprime O\nminister O\nin O\n1984 O\nthat O\nan O\nastrologer O\nwas O\nasked O\nto O\nwarn O\nher O\nagainst O\nfuture O\nthreats O\n. O\n\nThe B-ORG\nSunday I-ORG\nTelegraph I-ORG\nquoted O\nMajorie B-PER\nOrr I-PER\nas O\nsaying O\nshe O\ndid O\na O\nhoroscope O\nchart O\nfor O\nThatcher B-PER\n, O\na O\nLibran B-MISC\n, O\nafter O\nshe O\nnarrowly O\nescaped O\ndeath O\nin O\nthe O\nIrish B-MISC\nguerrilla O\nbombing O\nof O\na O\nhotel O\nduring O\nthe O\nConservative B-ORG\nParty I-ORG\nconference O\nmore O\nthan O\na O\ndecade O\nago O\n. O\n\nOrr B-PER\nsaid O\nThatcher B-PER\n's O\npress O\nsecretary O\nBernard B-PER\nIngram I-PER\nasked O\nher O\nto O\ntelephone O\nif O\nshe O\nsaw O\nany O\nthreatening O\nindications O\nin O\nthe O\nfuture O\n. O\n\n\" O\nBernard B-PER\nIngham I-PER\ntold O\nme O\nthat O\nif O\nI O\never O\nheard O\nanything O\nthat O\nindicated O\ndanger O\nI O\nwas O\nto O\nlet O\nhim O\nknow O\n, O\n\" O\nOrr B-PER\nsaid O\n. O\n\nOrr B-PER\nsaid O\nshe O\nnever O\nhad O\nto O\ntelephone O\n. O\n\nShe O\nadded O\nthat O\nthe O\nhoroscope O\nwas O\npurely O\nfor O\nsecurity O\npurposes O\nand O\nshe O\nwas O\nnever O\nconsulted O\nabout O\npolitical O\nmoves O\n. O\n\nIngram B-PER\nwas O\nquoted O\nas O\ntelling O\nthe O\nnewspaper O\nhe O\nthought O\nastrology O\nwas O\n\" O\na O\nload O\nof O\nrubbish O\n\" O\nand O\nthat O\nhe O\ncould O\nnot O\nrecall O\nasking O\nOrr B-PER\nto O\nkeep O\na O\nwatch O\non O\nThatcher B-PER\n's O\nstars O\n. O\n\nThatcher B-PER\n, O\ndubbed O\nthe O\n\" O\nIron B-PER\nLady I-PER\n\" O\nfor O\nher O\ndriven O\n, O\nforceful O\npersonality O\n, O\nwas O\nnever O\nknown O\nto O\nhave O\nan O\ninterest O\nin O\nthe O\noccult O\nand O\nin O\nfact O\nhas O\na O\nuniversity O\ndegree O\nin O\nchemistry O\n. O\n\nFormer O\nU.S. B-LOC\npresident O\nRonald B-PER\nReagan I-PER\n's O\nwife O\n, O\nNancy B-PER\n, O\nadmitted O\nin O\nher O\nbiography O\nMy B-MISC\nTurn I-MISC\nthat O\nshe O\nregularly O\nconsulted O\nan O\nastrologer O\nto O\nhelp O\nher O\nplan O\nher O\nhusband O\n's O\nschedule O\n. O\n\n-DOCSTART- O\n\nReuters B-ORG\nhistorical O\ncalendar O\n- O\nSeptember O\n7 O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nFollowing O\nare O\nsome O\nof O\nthe O\nmajor O\nevents O\nto O\nhave O\noccurred O\non O\nSeptember O\n7 O\nin O\nhistory O\n. O\n\n1533 O\n- O\nQueen O\nElizabeth B-PER\nI I-PER\nborn O\n. O\n\nDaughter O\nof O\nHenry B-PER\nVIII I-PER\nand O\nhis O\nsecond O\nwife O\nAnne B-PER\nBoleyn I-PER\n, O\nshe O\nwas O\nqueen O\nof O\nEngland B-LOC\n1558-1603 O\n. O\n\nOne O\nof O\nthe O\ngreat O\nmonarchs O\nwho O\npresided O\nover O\na O\nperiod O\nof O\nEnglish B-MISC\nassertion O\nin O\nEurope B-LOC\nin O\npolitics O\nand O\nthe O\narts O\n. O\n\n1706 O\n- O\nFrench B-MISC\ntroops O\nunder O\nDuke O\nof O\nOrleans B-LOC\nbesieging O\nTurin B-LOC\nwere O\ndefeated O\nby O\nthe O\nAustrians B-MISC\nunder O\nPrince O\nEugene B-ORG\n, O\nthe O\nFrench B-MISC\narmy O\nwas O\ndestroyed O\nand O\nthey O\nceased O\ntrying O\nto O\ncapture O\nnorthern O\nItaly B-LOC\n. O\n\n1714 O\n- O\nThe O\nTreaty B-MISC\nof I-MISC\nBaden I-MISC\nwas O\nsigned O\nbetween O\nthe O\nHoly O\nRoman B-MISC\nEmperor O\nCharles B-PER\nVI I-PER\nand O\nFrance B-LOC\n, O\nending O\nWar B-MISC\nof I-MISC\nSpanish I-MISC\nSuccession I-MISC\n. O\n\nCharles B-PER\nceded O\nAlsace B-LOC\nand O\nStrasbourg B-LOC\nto O\nFrance B-LOC\nand O\ngot O\nback O\nBreisach B-LOC\n, O\nKehl B-LOC\nand O\nFreiburg B-LOC\n. O\n\n1812 O\n- O\nRussian B-MISC\narmy O\nunder O\nGeneral O\nKutuzov B-PER\nwas O\ndefeated O\nat O\nheavy O\ncost O\nby O\nNapoleon B-PER\nat O\nthe O\nbattle O\nof O\nBorodino B-LOC\n70 O\nmiles O\nwest O\nof O\nMoscow B-LOC\n. O\n\nNapoleon B-PER\nentered O\nMoscow B-LOC\na O\nweek O\nlater O\n. O\n\n1822 O\n- O\nBrazil B-LOC\nproclaimed O\nindependence O\nfrom O\nPortugal B-LOC\nand O\nPedro B-PER\nI I-PER\nbecame O\nfirst O\nEmperor O\nof O\nBrazil B-LOC\nin O\nDecember O\n1822 O\n. O\n\n1836 O\n- O\nScottish B-MISC\npolitician O\nSir O\nHenry B-PER\nCampbell-Bannerman I-PER\nborn O\n. O\n\nAs O\nLiberal B-MISC\nprime O\nminister O\n1905-1908 O\nhe O\ngranted O\nself-government O\nto O\nthe O\nTransvaal B-LOC\n. O\n\nHe O\nalso O\ngot O\nthe O\nHouse B-ORG\nof I-ORG\nLords I-ORG\nto O\npass O\nhis O\nTrades B-MISC\nDisputes I-MISC\nAct I-MISC\nwhich O\ngave O\nlabour O\nunions O\nmore O\nfreedom O\nto O\nstrike O\n. O\n\n1860 O\n- O\nGiuseppe B-PER\nGaribaldi I-PER\nleading O\nhis O\n\" O\nRed B-MISC\nShirts I-MISC\n\" O\nseized O\nNaples B-LOC\nin O\nthe O\nItalian B-MISC\nwar O\nof O\nliberation O\nagainst O\nthe O\nAustrians B-MISC\n. O\n\n1901 O\n- O\nIn O\nChina B-LOC\n, O\nthe O\nBoxer B-MISC\nRising I-MISC\nwhich O\nattempted O\nto O\ndrive O\nout O\nall O\nforeigners O\nofficially O\nended O\nwith O\nthe O\nsigning O\nof O\nthe O\nPeking B-MISC\nProtocol I-MISC\n. O\n\nThis O\nimposed O\nan O\nindemnity O\nto O\nbe O\npaid O\nto O\nthe O\ngreat O\npowers O\nfor O\nBoxer B-MISC\ncrimes O\n. O\n\n1909 O\n- O\nElia B-PER\nKazan I-PER\nborn O\nas O\nElia B-PER\nKazanjoglus I-PER\n. O\n\nA O\nU.S. B-LOC\nstage O\nand O\nscreen O\ndirector O\n, O\nhe O\nis O\nbest O\nknown O\nfor O\n\" O\nViva B-MISC\nZapata I-MISC\n\" O\nand O\n\" O\nOn B-MISC\nthe I-MISC\nWaterfront I-MISC\n\" O\n. O\n\n1913 O\n- O\nSir O\nAnthony B-PER\nQuayle I-PER\nborn O\n. O\n\nBritish B-MISC\nactor O\nof O\nstage O\nand O\nscreen O\nin O\nfilms O\nfrom O\n1948 O\n. O\n\nBest O\nknown O\nfor O\nappearances O\nin O\n\" O\nIce B-MISC\nCold I-MISC\nin I-MISC\nAlex I-MISC\n\" O\n, O\n\" O\nLawrence B-MISC\nof I-MISC\nArabia I-MISC\n\" O\nand O\n, O\nas O\nCardinal O\nWolsey B-PER\n, O\nin O\n\" O\nAnne B-MISC\nof I-MISC\na I-MISC\nThousand I-MISC\nDays I-MISC\n\" O\n. O\n\n1914 O\n- O\nJames B-PER\nAlfred I-PER\nVan I-PER\nAllen I-PER\nborn O\n. O\n\nU.S. B-LOC\nphysicist O\nwho O\ndiscovered O\nthe O\ntwo O\nzones O\nof O\nradiation O\nencircling O\nthe O\nearth O\nto O\nwhich O\nhe O\ngave O\nhis O\nname O\n. O\n\n1930 O\n- O\nBelgian B-MISC\nKing O\nBaudouin B-PER\nI I-PER\nborn O\n. O\n\nHe O\nsucceeded O\nto O\nthe O\nthrone O\nin O\n1951 O\non O\nthe O\nabdication O\nof O\nhis O\nfather O\nLeopold B-PER\nIII I-PER\n. O\n\n1940 O\n- O\nIn O\nWorld B-MISC\nWar I-MISC\nTwo I-MISC\nthe O\nGerman B-MISC\nairforce O\nunder O\nHermann B-PER\nGoering I-PER\nbegan O\nits O\n\" O\nBlitz B-MISC\n\" O\nbombing O\ncampaign O\non O\nLondon B-LOC\n. O\n\nOver O\n300 O\npeople O\nwere O\nkilled O\non O\nthis O\nday O\nalone O\n. O\n\n1969 O\n- O\nScottish B-MISC\nmotor O\nracing O\ndriver O\nJackie B-PER\nStewart I-PER\nwon O\nthe O\nItalian B-MISC\nGrand I-MISC\nPrix I-MISC\nto O\nsecure O\nhis O\nfirst O\nworld O\nchampionship O\n. O\n\nFour O\nyears O\nlater O\n, O\nafter O\nwinning O\nhis O\nthird O\nworld O\ncrown O\n, O\nhe O\nannounced O\nhis O\nretirement O\n. O\n\n1986 O\n- O\nBishop O\nDesmond B-PER\nTutu I-PER\nwas O\nenthroned O\nas O\nArchbishop O\nof O\nCape B-LOC\nTown I-LOC\n, O\nSouth B-LOC\nAfrica I-LOC\n. O\n\nHe O\nwas O\nthe O\nfirst O\nblack O\nhead O\nof O\nSouth B-LOC\nAfrica I-LOC\n's O\nAnglicans B-MISC\n. O\n\n1990 O\n- O\nThe O\nUnited B-LOC\nStates I-LOC\nwon O\nSaudi B-MISC\nand O\nKuwaiti B-MISC\npledges O\nto O\nhelp O\npay O\nfor O\nforces O\nin O\nthe O\nGulf B-LOC\n. O\n\nIraq B-LOC\nordered O\nmany O\nrestaurants O\nto O\nclose O\nindefinitely O\nto O\nsave O\nfood O\nin O\nface O\nof O\na O\nblockade O\n. O\n\n1990 O\n- O\nBritish B-MISC\nhistorian O\nAlan B-PER\nJohn I-PER\nPercivale I-PER\n( I-PER\nA.J.P. I-PER\n) I-PER\nTaylor I-PER\ndied O\n. O\n\nHe O\nwon O\nacclaim O\nfor O\nthe O\ninsights O\nthat O\nhe O\ngave O\ninto O\nthe O\nevents O\nwhich O\nshaped O\nmodern O\nEurope B-LOC\nand O\nwas O\none O\nof O\nEurope B-LOC\n's O\nleading O\nauthorities O\non O\nthe O\ngreat O\nconflicts O\nof O\nthe O\n20th O\ncentury O\n. O\n\n1993 O\n- O\nSix O\nformer O\nSoviet B-MISC\nrepublics O\n, O\nRussia B-LOC\n, O\nBelarus B-LOC\n, O\nKazakhstan B-LOC\n, O\nUzbekistan B-LOC\n, O\nArmenia B-LOC\nand O\nTajikistan B-LOC\n, O\nsigned O\nframework O\nagreement O\nto O\nkeep O\nthe O\nRussian B-MISC\nrouble O\nas O\ntheir O\ncommon O\ncurrency O\n. O\n\n1994 O\n- O\nThe O\nStars B-MISC\nand I-MISC\nStripes I-MISC\nflag O\nwas O\nlowered O\nfor O\nthe O\nlast O\ntime O\nover O\nU.S. B-LOC\narmy O\nheadquarters O\nin O\nBerlin B-LOC\n, O\nformally O\nending O\nthe O\nAmerican B-MISC\npresence O\nin O\nthe O\nonce-divided O\ncity O\nafter O\nnearly O\nhalf O\na O\ncentury O\n. O\n\n-DOCSTART- O\n\nEscaped O\nBritish B-MISC\npaedophile O\nrecaptured O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nA O\nconvicted O\nBritish B-MISC\npaedophile O\nwas O\narrested O\non O\nSaturday O\n, O\ntwo O\ndays O\nafter O\nescaping O\nfrom O\ncustody O\nduring O\na O\nsupervised O\nday O\ntrip O\nto O\na O\nzoo O\n, O\npolice O\nsaid O\n. O\n\nTrevor B-PER\nHolland I-PER\n, O\na O\n52 O\nyear-old O\nwith O\nwho O\nhas O\nbeen O\nconvicted O\ntwice O\nof O\ngross O\nindecency O\nwith O\nchildren O\n, O\nwas O\ncaptured O\nafter O\nbeing O\nspotted O\nin O\nWorthing B-LOC\n, O\na O\ntown O\non O\nEngland B-LOC\n's O\nsouthern O\ncoast O\n. O\n\n\" O\nA O\nmember O\nof O\nthe O\npublic O\nrecognised O\nHolland B-PER\nin O\na O\nnewsagent O\nshop O\nas O\nhe O\nwas O\nreading O\nthe O\nheadlines O\nabout O\nhimself O\n, O\n\" O\na O\npolice O\nspokesman O\nsaid O\n. O\n\nPolice O\nlaunched O\na O\nnationwide O\nsearch O\non O\nThursday O\nafter O\nhe O\ndisappeared O\nduring O\nan O\nunsupervised O\ntrip O\nto O\nthe O\ntoilet O\nwhile O\nvisiting O\na O\npopular O\nzoo O\nand O\ntheme O\npark O\nsouth O\nof O\nLondon B-LOC\n. O\n\nHolland B-PER\nwas O\nmoved O\nto O\na O\nmore O\nsecure O\ncentre O\nearlier O\nthis O\nyear O\nafter O\na O\nsimilar O\nincident O\n. O\n\nHis O\nescape O\nat O\nthe O\nzoo O\ncaused O\noutrage O\nin O\nBritain B-LOC\n. O\n\nA O\nchild O\nsex O\nscandal O\nin O\nBelgium B-LOC\nin O\nwhich O\ntwo O\neight-year-old O\ngirls O\nwere O\nmurdered O\nand O\ntwo O\nother O\nsexually O\nabused O\ngirls O\nwere O\nrescued O\nhas O\nfocused O\nnew O\nattention O\non O\nthe O\nproblem O\n. O\n\n-DOCSTART- O\n\nScottish B-ORG\nLabour I-ORG\nParty I-ORG\nnarrowly O\nbacks O\nreferendum O\n. O\n\nSTIRLING B-LOC\n, O\nScotland B-LOC\n1996-08-31 O\n\nBritish B-ORG\nLabour I-ORG\nParty I-ORG\nleader O\nTony B-PER\nBlair I-PER\nwon O\na O\nnarrow O\nvictory O\non O\nSaturday O\nwhen O\nthe O\nparty O\n's O\nScottish B-MISC\nexecutive O\nvoted O\n21-18 O\nin O\nfavour O\nof O\nhis O\nplans O\nfor O\na O\nreferendum O\non O\na O\nseparate O\nparliament O\nfor O\nScotland B-LOC\n. O\n\nBlair B-PER\nonce O\npledged O\nto O\nset O\nup O\na O\nScottish B-MISC\nparliament O\nif O\nthe O\nLabour B-ORG\nwon O\nthe O\nnext O\ngeneral O\nelection O\n, O\nwhich O\nmust O\nbe O\nheld O\nby O\nMay O\n1997 O\n. O\n\nBut O\nmany O\nactivists O\nwere O\ndismayed O\nwhen O\nhe O\nabruptly O\ndecided O\nearlier O\nthis O\nyear O\nto O\nhold O\na O\ntwo-question O\nreferendum O\non O\nthe O\nissue O\n, O\nasking O\nScots B-MISC\nif O\nthey O\nwanted O\na O\nseparate O\nparliament O\nand O\nif O\nit O\nshould O\nhave O\ntax-raising O\npowers O\n. O\n\nMany O\nparty O\nmembers O\nargued O\nthat O\na O\ngeneral O\nelection O\nwin O\nwould O\ndemonstrate O\npopular O\nsupport O\nfor O\na O\nseparate O\nparliament O\nand O\nothers O\nsaid O\na O\nsingle O\nquestion O\nreferendum O\nwould O\nsuffice O\n. O\n\nPrime O\nMinister O\nJohn B-PER\nMajor I-PER\nsays O\nthe O\n300-year-old O\nunion O\nof O\nthe O\nScottish B-MISC\nand O\nEnglish B-MISC\nparliaments O\nwill O\nbe O\na O\nmain O\nplank O\nin O\nhis O\nConservative B-ORG\nParty I-ORG\n's O\nelection O\nplatform O\n. O\n\nConservatives O\nhave O\nonly O\n10 O\nof O\nthe O\n72 O\nScottish B-MISC\nseats O\nin O\nparliament O\nand O\nconsistently O\nrun O\nthird O\nin O\nopinion O\npolls O\nin O\nScotland B-LOC\nbehind O\nLabour B-ORG\nand O\nthe O\nindependence-seeking O\nScottish B-ORG\nNational I-ORG\nParty I-ORG\n. O\n\n-DOCSTART- O\n\nBritain B-LOC\ncondemns O\nIraq B-LOC\ninvolvement O\nin O\nArbil B-LOC\nattack O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nBritain B-LOC\non O\nSaturday O\ncondemned O\nIraqi B-MISC\ninvolvement O\nin O\nan O\nattack O\non O\nthe O\nKurdish B-MISC\ncity O\nof O\nArbil B-LOC\nand O\nsaid O\nit O\nwas O\nin O\nclose O\ntouch O\nwith O\nits O\nallies O\n. O\n\n\" O\nWe O\ncondemn O\nIraqi B-MISC\ninvolvement O\n. O\n\nIn O\nno O\nway O\ncan O\nIraqi B-MISC\ninvolvement O\nbe O\nseen O\nas O\nhelpful O\n, O\n\" O\nsaid O\na O\nForeign B-ORG\nOffice I-ORG\nspokesman O\n. O\n\nU.N. B-ORG\nofficials O\nsaid O\nthat O\na O\nKurdish B-MISC\nrebel O\nfaction O\nbacked O\nup O\nby O\nIraqi B-MISC\ntanks O\n, O\nheavy O\nartillery O\nand O\nhelicopters O\nhad O\ntaken O\ncontrol O\nof O\nhalf O\nof O\nthe O\ncity O\nafter O\nheavy O\nfighting O\n. O\n\nArbil B-LOC\nlies O\nwithin O\nthe O\nso-called O\nsafe O\nhaven O\nset O\nup O\nat O\nthe O\nend O\nof O\nthe O\n1991 O\nGulf B-MISC\nWar I-MISC\non O\nthe O\nsuggestion O\nof O\nBritish B-MISC\nPrime O\nMinister O\nJohn B-PER\nMajor I-PER\nto O\nprotect O\nIraqi B-MISC\nKurds I-MISC\nfrom O\nattack O\nby O\nthe O\nIraqi B-MISC\nmilitary O\n. O\n\nThe O\narea O\nis O\npatrolled O\nby O\nU.S. B-LOC\n, O\nFrench B-MISC\nand O\nBritish B-MISC\nplanes O\n. O\n\n\" O\nWe O\nare O\nin O\nclose O\ntouch O\nwith O\nall O\nour O\nallies O\n, O\n\" O\nsaid O\nthe O\nForeign B-ORG\nOffice I-ORG\nspokesman O\n. O\n\nHe O\ndeclined O\nto O\ngive O\nany O\nfurther O\ninformation O\n. O\n\n-DOCSTART- O\n\nSeven O\nIraqis B-MISC\ncharged O\nwith O\nhijack O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nSeven O\nIraqi B-MISC\nmen O\nappeared O\nin O\ncourt O\non O\nSaturday O\ncharged O\nwith O\nair O\npiracy O\nfollowing O\nthe O\nhijacking O\nto O\nBritain B-LOC\nof O\na O\nSudanese B-MISC\nairliner O\nwith O\n199 O\npeople O\naboard O\n. O\n\nThe O\nseven O\n, O\nincluding O\na O\ncarpenter O\nand O\na O\nbusinessmen O\nand O\nwhose O\nages O\nranged O\nfrom O\n25 O\nto O\n38 O\nyears O\nold O\n, O\nwere O\nordered O\nto O\nbe O\nheld O\nin O\njail O\nuntil O\nanother O\nhearing O\nnext O\nweek O\n. O\n\nNo O\npleas O\nwere O\nentered O\nat O\nthe O\npreliminary O\nhearing O\n. O\n\nThey O\nwere O\naccused O\nof O\ntaking O\nover O\nFlight B-MISC\n150 I-MISC\nwhich O\nwas O\nflying O\nfrom O\nKhartoum B-LOC\n, O\nSudan B-LOC\n, O\nto O\nAmman B-LOC\n, O\nJordan B-LOC\n. O\n\nAll O\nthe O\nhostages O\nwere O\nfreed O\non O\nTuesday O\nafter O\nthe O\nplane O\nlanded O\nat O\nStansted B-LOC\nairport O\n, O\nnorth O\nof O\nLondon B-LOC\n. O\n\nThe O\nmen O\nhave O\nclaimed O\npolitical O\nasylum O\nin O\nBritain B-LOC\nsaying O\nthey O\nwere O\npersecuted O\nwhile O\nin O\nIraq B-LOC\n. O\n\nTheir O\ncourt O\nappearance O\nmeans O\nthey O\nwill O\nface O\ntrial O\nand O\npossible O\nimprisonment O\nin O\nBritain B-LOC\nbefore O\ntheir O\napplications O\nfor O\nasylum O\nare O\nconsidered O\n. O\n\nUnder O\nEnglish B-MISC\nlaw O\nthe O\nmaximum O\nsentence O\nfor O\nhijack O\nis O\nlife O\nimprisonment O\nbut O\nthere O\nhas O\nbeen O\nwidespread O\nspeculation O\nthat O\nthe O\nseven O\nwill O\nreceive O\nlesser O\nsentences O\n. O\n\nAfter O\na O\nsearch O\nof O\nthe O\naircraft O\nfollowing O\nthe O\nhijack O\n, O\npolice O\nfound O\nonly O\nknives O\nand O\nfake O\nexplosives O\n. O\n\n-DOCSTART- O\n\nOpposition O\ngroup O\nsays O\nIraqis B-MISC\nadvance O\nin O\nnorth O\nIraq B-LOC\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nAn O\nIraqi B-MISC\nopposition O\ngroup O\nin O\nexile O\nsaid O\non O\nSaturday O\nit O\nhad O\nreceived O\nreports O\nthat O\nIraqi B-MISC\nforces O\nwere O\nshelling O\nand O\nadvancing O\non O\nthe O\nKurdish B-MISC\ntown O\nof O\nArbil B-LOC\nin O\nnorthern O\nIraq B-LOC\n. O\n\nA O\nLondon-based B-MISC\nspokesman O\nof O\nthe O\nIraqi B-ORG\nNational I-ORG\nCongress I-ORG\nsaid O\nIraqi B-MISC\nartillery O\nwas O\nshelling O\nthe O\ncity O\nand O\nIraqi B-MISC\ntanks O\nhad O\nadvanced O\nto O\nwithin O\n10 O\nkm O\n( O\nsix O\nmiles O\n) O\nof O\nArbil B-LOC\n, O\nthe O\nadministrative O\ncentre O\nof O\nthe O\nKurdish B-MISC\nrebel-controlled O\nregion O\nof O\nnorthern O\nIraq B-LOC\n. O\n\n\" O\nAt O\n4.50 O\na.m. O\nIraq B-LOC\ntime O\n( O\n0050 O\nGMT B-MISC\n) O\nIraqi B-MISC\nforces O\nbegan O\nan O\nartillery O\nattack O\non O\nthe O\noutskirts O\nof O\nArbil B-LOC\n, O\n\" O\nthe O\nspokesman O\n, O\nwho O\nasked O\nnot O\nto O\nbe O\nidentified O\n, O\ntold O\nReuters B-ORG\nin O\na O\ntelephone O\ncall O\n. O\n\nThere O\nwas O\nno O\nindependent O\nconfirmation O\nof O\nthe O\nreport O\nwhich O\nthe O\nspokesman O\nsaid O\ncame O\nfrom O\nthe O\norganisation O\n's O\nmembers O\nin O\nArbil B-LOC\n. O\n\nHe O\nsaid O\ndamage O\nand O\ncasualties O\nin O\nthe O\ncity O\nwere O\nheavy O\nand O\nKurdish B-MISC\nforces O\nwere O\ndefending O\nthe O\ncity O\n. O\n\nPresident O\nBill B-PER\nClinton I-PER\non O\nFriday O\nordered O\nthe O\nU.S. B-LOC\nmilitary O\nto O\nready O\nitself O\nfor O\nany O\npossible O\naction O\nas O\nWashington B-LOC\nturned O\nup O\nthe O\nheat O\nin O\nan O\nescalating O\ncrisis O\nover O\nIraqi B-MISC\ntroop O\nmovements O\nin O\nnorthern O\nIraq B-LOC\n. O\n\nOn O\nThursday O\n, O\nIraq B-LOC\naccused O\nIran B-LOC\nof O\naggression O\nand O\nsaid O\nit O\nreserved O\nthe O\nright O\nto O\nretaliate O\nfor O\nTehran B-LOC\n's O\nalleged O\ndeployment O\nof O\ntroops O\ninto O\nnorthern O\nIraq B-LOC\n, O\nwhere O\nfighting O\nbroke O\nout O\nbetween O\nthe O\ntwo O\nmain O\nIraqi B-MISC\nKurdish I-MISC\nrebel O\ngroups O\ntwo O\nweeks O\nago O\n. O\n\n-DOCSTART- O\n\nTwo O\ndie O\nin O\nAlgeria B-LOC\nrestaurant O\nblast O\n- O\nradio O\n. O\n\nLONDON B-LOC\n1996-08-31 O\n\nTwo O\npeople O\nwere O\nkilled O\nwhen O\na O\nhand O\ngrenade O\nexploded O\nin O\na O\nrestaurant O\nnear O\nAlgiers B-LOC\nlate O\non O\nFriday O\n, O\nAlgerian B-MISC\nradio O\nreported O\non O\nSaturday O\n. O\n\nThe O\nreport O\n, O\nmonitored O\nby O\nthe O\nBritish B-ORG\nBroadcasting I-ORG\nCorporation I-ORG\n( O\nBBC B-ORG\n) O\n, O\nquoted O\nsecurity O\nservices O\nas O\nsaying O\nsix O\nother O\npeople O\nwere O\ninjured O\nin O\nthe O\nblast O\nin O\nthe O\ntown O\nof O\nStaouelli B-LOC\n. O\n\nAn O\nestimated O\n50,000 O\npeople O\nhad O\nbeen O\nkilled O\nin O\npolitical O\nviolence O\nin O\nAlgeria B-LOC\nsince O\n1992 O\n, O\nwhen O\narmy-backed O\nauthorities O\ncancelled O\na O\ngeneral O\nelection O\nthat O\nIslamic B-MISC\nfundamentalists O\nhad O\nbeen O\nexpected O\nto O\nwin O\n. O\n\n-DOCSTART- O\n\nBaseball-Results O\nof O\nS. B-MISC\nKorean I-MISC\npro-baseball O\ngames O\n. O\n\nSEOUL B-LOC\n1996-08-31 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\npro-baseball O\ngames O\nplayed O\non O\nFriday O\n. O\n\nOB B-ORG\n5 O\nSamsung B-ORG\n0 O\n\nSsangbangwool B-ORG\n2 O\nHyundai B-ORG\n1 O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nFriday O\n( O\ntabulate O\nunder O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\nwinning O\npercentage O\n, O\ngames O\nbehind O\nfirst O\nplace O\n) O\n\nW O\nD O\nL O\nPCT O\nGB O\n\nHaitai B-ORG\n64 O\n2 O\n43 O\n.596 O\n- O\n\nSsangbangwool B-ORG\n60 O\n2 O\n49 O\n.550 O\n5 O\n\nHanwha B-ORG\n58 O\n1 O\n49 O\n.542 O\n6 O\n\nHyundai B-ORG\n57 O\n5 O\n50 O\n.531 O\n7 O\n\nSamsung B-ORG\n49 O\n5 O\n57 O\n.464 O\n14 O\n1/2 O\n\nLotte B-ORG\n46 O\n6 O\n54 O\n.462 O\n14 O\n1/2 O\n\nLG B-ORG\n46 O\n5 O\n59 O\n.441 O\n17 O\n\nOB B-ORG\n43 O\n6 O\n62 O\n.414 O\n20 O\n\n-DOCSTART- O\n\nS. B-MISC\nAfrican I-MISC\nAfrikaners B-MISC\nstill O\nseek O\nown O\nterritory O\n. O\n\nCAPE B-LOC\nTOWN I-LOC\n1996-08-31 O\n\nSouth B-MISC\nAfrican I-MISC\nright-wing O\nAfrikaners O\non O\nSaturday O\nrevived O\ntheir O\ncampaign O\nfor O\na O\nform O\nof O\nself-rule O\n, O\nidentifying O\na O\nsparsely-populated O\narea O\nin O\nNorthern B-LOC\nCape I-LOC\nprovince O\nas O\nthe O\nbest O\nplace O\nfor O\na O\nhome O\nof O\ntheir O\nown O\n. O\n\nConstand B-PER\nViljoen I-PER\n, O\nleader O\nof O\nthe O\nFreedom B-ORG\nFront I-ORG\nparty O\n, O\ntold O\na O\nnews O\nconference O\nin O\nPretoria B-LOC\nself-determination O\nfor O\nAfrikaners B-MISC\ncould O\nbegin O\nat O\nlocal O\ngovernment O\nlevel O\n. O\n\n\" O\nCertain O\npowers O\ncan O\nbe O\ndelegated O\nfrom O\nthe O\nprovincial O\nlevel O\n, O\ntowards O\nthe O\nsub-regions O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nWe O\nthink O\nthat O\nthe O\nAfrikaner B-MISC\nmodel O\nwithin O\nthis O\nnew O\n, O\nmulti- O\nethnic O\nsociety O\nof O\nSouth B-LOC\nAfrica I-LOC\nwill O\nhave O\nto O\ndevelop O\nexperimentally O\nwith O\nworld O\nthinking O\nin O\nthis O\nregard O\n. O\n\" O\n\nViljoen B-PER\nbroke O\nwith O\nother O\nright-wing O\nwhites O\nin O\n1994 O\nby O\ntaking O\npart O\nin O\nthe O\ncountry O\n's O\nfirst O\nall-race O\nelections O\nin O\nApril O\nof O\nthat O\nyear O\n, O\nsaying O\nthe O\nonly O\nway O\nto O\nattain O\nself-determination O\nwas O\nby O\ncooperating O\nwith O\nPresident O\nNelson B-PER\nMandela I-PER\n's O\nmajority O\nAfrican B-ORG\nNational I-ORG\nCongress I-ORG\n. O\n\nSome O\nright-wingers O\ndemanded O\nsovereignty O\nin O\ntheir O\nown O\nterritory O\nin O\nthe O\nrun-up O\nto O\nthe O\nelections O\n, O\nsaying O\nthe O\nalternative O\nwas O\nwar O\n. O\n\nTheir O\nthreats O\ncame O\nto O\nnothing O\n. O\n\nViljoen B-PER\nhas O\nhailed O\nclauses O\nin O\nSouth B-LOC\nAfrica I-LOC\n's O\nnew O\nconstitution O\nas O\nmaking O\npossible O\na O\nform O\nof O\nself-rule O\nfor O\nthe O\nAfrikaners B-MISC\n, O\ndescendants O\nof O\nthe O\ncountry O\n's O\nDutch B-MISC\n, O\nGerman B-MISC\nand O\nFrench B-MISC\nsettlers O\n. O\n\nAccording O\nto O\nstate O\ntelevision O\n, O\nViljoen B-PER\ntold O\nthe O\nnews O\nconference O\nthe O\nself-rule O\nmodel O\nshould O\nbe O\nintroduced O\nin O\nparts O\nof O\nthe O\nNorthern B-LOC\nCape I-LOC\nprovinces O\nwhere O\na O\nmajority O\nof O\npeople O\n-- O\nwhites O\nand O\nmixed-race O\nColoureds O\n-- O\nspeak O\nAfrikaans B-MISC\n. O\n\n-DOCSTART- O\n\nRwandan B-MISC\nrefugee O\ngroup O\ncalls O\nfor O\ncalm O\nover O\ncensus O\n. O\n\nNAIROBI B-LOC\n1996-08-31 O\n\nA O\nRwandan B-MISC\nrefugee O\nlobby O\ngroup O\ncalled O\non O\nSaturday O\nfor O\ncalm O\nin O\nrefugee O\ncamps O\nin O\neastern O\nZaire B-LOC\nduring O\na O\ncensus O\nfrom O\nSunday O\nto O\nbe O\nconducted O\nby O\naid O\nworkers O\n. O\n\nThe O\nRally B-ORG\nfor I-ORG\nthe I-ORG\nReturn I-ORG\nof I-ORG\nRefugees I-ORG\nand I-ORG\nDemocracy I-ORG\nin I-ORG\nRwanda I-ORG\n( O\nRDR B-ORG\n) O\nurged O\nthe O\nU.N. B-ORG\nHigh O\nCommissioner O\nfor O\nRefugees O\nto O\navoid O\nany O\n\" O\npolicing O\napproach O\n\" O\nand O\nto O\ncalm O\nrefugees O\nby O\nexplaining O\nthe O\naims O\nof O\nthe O\noperation O\n. O\n\n\" O\nThe O\nRDR B-ORG\nappeals O\nto O\nall O\nrefugees O\nto O\nprepare O\nthemselves O\ncalmly O\nfor O\nthe O\ndemands O\nof O\nthe O\ncensus O\nagents O\nbecause O\nit O\nwill O\nbe O\nin O\ntheir O\nultimate O\ninterest O\n, O\n\" O\nthe O\ngroup O\nsaid O\nin O\na O\nstatement O\n. O\n\nIt O\nsaid O\nrefugees O\nfeared O\ncensus O\ntakers O\nwould O\nuse O\nindelible O\nink O\nto O\nmark O\nthem O\nso O\nthey O\ncould O\nbe O\ndetected O\nby O\nRwandan B-MISC\ngovernment O\ntroops O\nand O\nmistreated O\nif O\nthey O\nwere O\nforced O\nback O\ninto O\nRwanda B-LOC\n. O\n\nU.N. B-ORG\nofficials O\nsaid O\nmore O\nthan O\n1,000 O\naid O\nworkers O\nwill O\ntake O\npart O\nin O\nthe O\ncensus O\nfrom O\nSunday O\nuntil O\nTuesday O\nof O\nthe O\nestimated O\n727,000 O\nrefugees O\nin O\ncamps O\naround O\nthe O\neastern O\nZairean B-MISC\nborder O\ntown O\nof O\nGoma B-LOC\n. O\n\nOnly O\nabout O\n100 O\nrefugees O\na O\nweek O\nare O\nreturning O\nvoluntarily O\nto O\nRwanda B-LOC\nin O\ncontrast O\nto O\nthe O\n600 O\nbabies O\nborn O\nin O\nthe O\ncamps O\nweekly O\n. O\n\nZairean B-MISC\nPrime O\nMinister O\nKengo B-PER\nwa I-PER\nDondo I-PER\nsaid O\nat O\nthe O\nend O\nof O\na O\nvisit O\nto O\nRwanda B-LOC\nlast O\nweek O\nthat O\nthe O\nZairean B-MISC\nand O\nRwandan B-MISC\ngovernments O\nagreed O\non O\nan O\n\" O\norganised O\n, O\nmassive O\nand O\nunconditional O\nrepatriation O\n\" O\nof O\nthe O\n1.1 O\nmillion O\nRwandan B-MISC\nrefugees O\nin O\nZaire B-LOC\n. O\n\nHe O\nsaid O\nthe O\nrepatriation O\nwould O\nbe O\ncarried O\nout O\nswiftly O\nand O\nwould O\nbe O\nenormous O\n, O\nstarting O\nwith O\nthe O\nclosure O\nof O\nrefugee O\ncamps O\n. O\n\nRDR B-ORG\nsaid O\nit O\nfeared O\nforced O\nexpulsions O\nwould O\nstart O\nin O\ndays O\n. O\n\nZairean B-MISC\ntroops O\nexpelled O\n15,000 O\nrefugees O\nin O\nAugust O\nlast O\nyear O\n. O\n\nMany O\nof O\nthe O\n1.1 O\nmillion O\nRwandan B-MISC\nHutu B-MISC\nrefugees O\nin O\nZaire B-LOC\nand O\nnearly O\n600,000 O\nin O\nTanzania B-LOC\nrefuse O\nto O\ngo O\nhome O\n, O\nsaying O\nthey O\nfear O\nreprisals O\nfor O\nthe O\n1994 O\ngenocide O\nin O\nRwanda B-LOC\nof O\nup O\nto O\na O\nmillion O\npeople O\nby O\nHutus B-MISC\n. O\n\n-DOCSTART- O\n\nNATO B-ORG\nmonitors O\nMoslem B-MISC\nmove O\ntowards O\ntense O\nvillage O\n. O\n\nMAHALA B-LOC\n, O\nBosnia B-LOC\n1996-08-31 O\n\nNATO B-ORG\nsaid O\nit O\nwas O\nclosely O\nmonitoring O\nthe O\nmovement O\nof O\nabout O\n75 O\nMoslem B-MISC\nmen O\ntowards O\nthe O\nvillage O\nof O\nMahala B-LOC\nin O\nBosnia B-LOC\n's O\nSerb B-MISC\nrepublic O\non O\nSaturday O\n, O\ntwo O\ndays O\nafter O\na O\nviolent O\nconfrontation O\nwith O\nSerbs B-MISC\n. O\n\n\" O\nI O\nhave O\nto O\nreport O\nthis O\nmorning O\nthat O\nwe O\nhave O\nin O\nfact O\nreceived O\nreports O\n... O\n\nthat O\nup O\nto O\n75 O\nMoslem B-MISC\nmen O\nare O\nbelieved O\nto O\nbe O\napproaching O\nMahala B-LOC\n, O\n\" O\nNATO B-ORG\nspokesman O\nLieutenant-Colonel O\nMax B-PER\nMarriner I-PER\nsaid O\nin O\nSarajevo B-LOC\n. O\n\nMarriner B-PER\nsaid O\nthat O\nNATO B-ORG\ntroops O\nhad O\nset O\nup O\na O\ncheckpoint O\non O\nthe O\nroad O\nbetween O\nTuzla B-LOC\nand O\nMahala B-LOC\nto O\nestablish O\nthe O\nidentities O\nand O\nintentions O\nof O\nthe O\nmen O\nheaded O\ntowards O\nthe O\nvillage O\n. O\n\nMahala B-LOC\nis O\na O\nMoslem B-MISC\nvillage O\non O\nBosnian B-MISC\nSerb I-MISC\nrepublic O\nterritory O\n. O\n\nMoslems B-MISC\nwere O\ndriven O\nfrom O\nthe O\nvillage O\nduring O\nthe O\n43- O\nmonth O\nBosnian B-MISC\nwar O\nand O\nmost O\nof O\ntheir O\nhouses O\nwere O\ndestroyed O\n. O\n\nSome O\nMoslems B-MISC\nbegan O\nreturning O\nto O\nrebuild O\ntheir O\nproperties O\nearlier O\nin O\nthe O\nweek O\n. O\n\nFights O\nand O\nshooting O\nbroke O\nout O\nbetween O\nthe O\nMoslems B-MISC\nand O\nSerb B-MISC\npolice O\non O\nThursday O\nand O\nNATO B-ORG\ntroops O\nfinally O\nbrought O\nrestored O\norder O\n. O\n\nA O\nReuters B-ORG\nreporter O\nwho O\nentered O\nMahala B-LOC\non O\nSaturday O\nmorning O\nfound O\nit O\ntranquil O\nbut O\nNATO B-ORG\ntroops O\nand O\nU.N. B-ORG\npolice O\nwere O\nseen O\non O\nthe O\nground O\nand O\nNATO B-ORG\nhelicopters O\nflew O\noverhead O\n. O\n\n-DOCSTART- O\n\nChechens B-MISC\nexuberant O\nbut O\ncautious O\non O\npeace O\ndeal O\n. O\n\nLiutauras B-PER\nStremaitis I-PER\n\nURUS-MARTAN B-LOC\n, O\nRussia B-LOC\n1996-08-31 O\n\nCrowds O\nof O\npro-independence O\nChechens B-MISC\ngreeted O\na O\nnewly-signed O\npeace O\ndeal O\nby O\nsinging O\n, O\ndancing O\nand O\nfiring O\nguns O\nin O\nthe O\nair O\non O\nSaturday O\n, O\nbut O\nthe O\ncelebrations O\nheld O\na O\ntrace O\nof O\nuncertainty O\n. O\n\nMore O\nthan O\na O\nthousand O\nwomen O\n, O\nchildren O\nand O\nmen O\ngathered O\nin O\na O\nfield O\nto O\nthe O\nnorth O\nof O\nthe O\ntown O\nof O\nUrus-Martan B-LOC\non O\nSaturday O\nto O\nwait O\nfor O\na O\ncolumn O\nof O\nrebels O\nto O\nwithdraw O\nfrom O\nthe O\ncapital O\nGrozny B-LOC\nabout O\n25 O\nkm O\n( O\n12 O\nmiles O\n) O\naway O\n. O\n\nThe O\nmen O\nfired O\nweapons O\ninto O\nthe O\nair O\nas O\ngroups O\nof O\nwomen O\ndanced O\n. O\n\nAdults O\nin O\nthe O\ncrowd O\ncarried O\nposters O\nof O\nformer O\nChechen B-MISC\nleader O\nDzhokhar B-PER\nDudayev I-PER\n-- O\nwho O\ndeclared O\nindependence O\nin O\n1991 O\n-- O\nand O\nchildren O\n, O\ncarrying O\nphotographs O\nof O\nhim O\n, O\ncalled O\n\" O\nTroops O\nout O\n! O\n\" O\n\n. O\n\nRussian B-MISC\nmilitary O\nofficials O\nhave O\nexpressed O\nfears O\nthat O\nthe O\nrebels O\nand O\ntheir O\nsupporters O\nwill O\nsee O\nthe O\ndeal O\nsigned O\nby O\nRussian B-MISC\npeace O\nenvoy O\nAlexander B-PER\nLebed I-PER\nin O\nthe O\nearly O\nhours O\nof O\nSaturday O\nas O\na O\nmilitary O\nvictory O\nfor O\nthe O\nseparatists O\n. O\n\nIt O\ninvolves O\nthe O\nwithdrawal O\nof O\nRussian B-MISC\ntroops O\nsent O\nto O\nChechnya B-LOC\nin O\nDecember O\n1994 O\nto O\ncrush O\nthe O\nseparatists O\nand O\na O\npostponement O\nof O\nthe O\nissue O\nat O\nthe O\nheart O\nof O\nthe O\nconflict O\n-- O\nthe O\nstatus O\nof O\nthe O\nmainly-Moslem B-MISC\nNorth B-LOC\nCaucasus I-LOC\nregion O\n. O\n\nBut O\nthe O\npeople O\nin O\nthe O\ncrowd O\non O\nSaturday O\n, O\nwho O\nhad O\nturned O\nout O\nin O\nsupport O\nof O\nthe O\nrebels O\n, O\ndid O\nnot O\nseem O\nsure O\nthat O\nthe O\nwar O\nwas O\nover O\n. O\n\n\" O\nWe O\nhope O\nfor O\nthe O\nbest O\n, O\nthat O\nit O\nreally O\nhas O\nended O\nso O\nwe O\ncan O\nlive O\nin O\npeace O\n. O\n\nIt O\n's O\nour O\nonly O\ndream O\n, O\n\" O\nsaid O\na O\n30-year-old O\nwoman O\n, O\nMubatik B-PER\nDagayeva I-PER\n. O\n\nAiza B-PER\nDudayeva I-PER\n, O\nwith O\nher O\n10-year-old O\nson O\nbeside O\nher O\n, O\nshared O\nthe O\nguarded O\noptimism O\n. O\n\" O\n\nWe O\nreally O\nwant O\nthe O\nwar O\nto O\nend O\n, O\nwe O\nhope O\nand O\nbelieve O\nthat O\nour O\nsons O\nand O\nbrothers O\nwill O\nwin O\n, O\n\" O\nsaid O\nDudayeva B-PER\n, O\nadding O\nthat O\nshe O\nwas O\nfrom O\nUrus-Martan B-LOC\n. O\n\nUrus-Martan B-LOC\nis O\na O\ntraditionally O\nanti-separatist O\npocket O\nin O\nChechnya B-LOC\nand O\nMoscow-backed B-MISC\nleader O\nDoku B-PER\nZavgayev I-PER\n, O\nwho O\nhas O\nbeen O\nsidelined O\nin O\nthe O\npeace O\ndeal O\n, O\nhas O\nwarned O\nthat O\nit O\nand O\nplaces O\nlike O\nit O\ncould O\nbecome O\ncentres O\nof O\ncivil O\nwar O\nif O\nRussian B-MISC\ntroops O\nleave O\n. O\n\nBut O\non O\nSaturday O\nthe O\npeople O\ngathered O\njust O\noutside O\nthe O\ntown O\nseemed O\nto O\nbe O\nunited O\nin O\nfavour O\nof O\nthe O\nseparatists O\n. O\n\nTwo O\ncolumns O\nof O\nrebels O\nappeared O\nin O\njeeps O\nand O\ncars O\n, O\nfiring O\ntheir O\nguns O\nin O\nthe O\nair O\n, O\nas O\nthe O\ncrowd O\nrushed O\ntowards O\nthem O\n. O\n\nMouldi B-PER\nMamatuyev I-PER\n, O\nin O\nhis O\nlate O\n20 O\n's O\n, O\ndressed O\nin O\nblack O\nand O\ncarrying O\na O\nmachine O\ngun O\n, O\nwas O\nwelcomed O\nby O\nhis O\nmother O\nand O\nsister O\n. O\n\n\" O\nTwo O\nsons O\nhave O\ncome O\nback O\n, O\n\" O\nsaid O\nhis O\nmother O\nNurbika B-PER\nMamatuyeva I-PER\n. O\n\" O\n\nIt O\n's O\nthe O\nend O\n. O\n\nWe O\nbelieve O\nin O\nGod B-PER\n. O\n\" O\n\nMamatuyev B-PER\njoked O\nthat O\nhis O\nsister O\nLisa B-PER\nwas O\na O\nrebel O\ntoo O\n, O\nand O\nshe O\nresponded O\nby O\ngrabbing O\nhold O\nof O\nhis O\ngun O\nand O\nshouting O\nthe O\nChechen B-MISC\nwar O\ncry O\n\" O\nAllahu B-PER\nAkhbar I-PER\n\" O\n( O\nGod B-PER\nis O\nGreatest O\n) O\nand O\n\" O\nFreedom O\nfor O\nChechnya B-LOC\n! O\n\" O\n\n. O\n\nThe O\nfighter O\n, O\nsitting O\nnext O\nto O\na O\nman O\ndressed O\nin O\ngreen O\nand O\ncarrying O\na O\ngrenade-launcher O\n, O\nsaid O\nthat O\nthe O\nstrict O\nIslamic B-MISC\nlaw O\nadopted O\nby O\nthe O\nrebels O\nduring O\nthe O\nconflict O\nwas O\nnow O\nneeded O\nto O\nimpose O\npeace O\n. O\n\n\" O\nThe O\nwar O\nhas O\nended O\nif O\neverything O\nworks O\nout O\n, O\nif O\nthere O\nis O\nlaw O\nthere O\nwill O\nbe O\npower O\n. O\n\nOnly O\nSheriat B-MISC\n( O\nIslamic B-MISC\nlaw O\n) O\ncan O\nend O\nthe O\nwar O\n. O\n\" O\n\n-DOCSTART- O\n\nPolish B-MISC\ngroup O\nto O\nbid O\nfor O\nRuch B-ORG\nnewsstand O\nchain O\n- O\npaper O\n. O\n\nWARSAW B-LOC\n1996-08-31 O\n\nA O\nPolish B-MISC\nconsortium O\nincluding O\nthe O\nBank B-ORG\nRozwoju I-ORG\nExportu I-ORG\nSA I-ORG\n( O\nBRE B-ORG\n) O\nplans O\nto O\nrival O\nFrance B-LOC\n's O\nHachette B-ORG\nin O\nbidding O\nfor O\nPolish B-MISC\nstate-owned O\npress O\ndistribution O\nchain O\nRuch B-ORG\nSA I-ORG\n, O\nZycie B-ORG\nWarszawy I-ORG\ndaily O\nsaid O\non O\nSaturday O\n. O\n\nZycie B-ORG\nWarszawy I-ORG\nsaid O\nits O\nown O\npublisher O\n, O\nmineral O\nwater O\nfirm O\nMultico B-ORG\n, O\nand O\na O\ngroup O\nheaded O\nby O\nPolish B-MISC\nbusinessman O\nZygmunt B-PER\nSolorz I-PER\nwere O\nforming O\na O\nconsortium O\nwhich O\nwould O\noffer O\nabout O\n$ O\n120 O\nmillion O\n, O\nwith O\nfinance O\nprovided O\nby O\nBRE B-ORG\n. O\n\nThe O\nconsortium O\nwanted O\n40 O\npercent O\nof O\nRuch B-ORG\n's O\nshares O\n, O\nthe O\nstate O\nwould O\nget O\n20 O\npercent O\nof O\nRuch B-ORG\nand O\n40 O\npercent O\nwould O\nbe O\noffered O\non O\nthe O\nWarsaw B-LOC\nstock O\nexchange O\n. O\n\n\" O\nThis O\ndivision B-MISC\nwould O\nguarantee O\na O\ndispersal O\nof O\ncapital O\n, O\npreventing O\nanyone O\nfrom O\ntaking O\ntotal O\ncontrol O\nover O\nRuch B-ORG\nand O\ndictating O\nmarket O\nconditions O\n, O\n\" O\nthe O\npaper O\nquoted O\none O\nof O\nthe O\ninitiators O\nof O\nthe O\nmove O\nas O\nsaying O\n, O\nwithout O\ngiving O\na O\nname O\n. O\n\nA O\nconsortium O\nof O\npress O\ndistributor O\nHachette B-ORG\nand O\nPolish B-MISC\npublishers O\ngroup O\nUWP B-ORG\nare O\nseeking O\nmore O\nthan O\nthan O\n50 O\npercent O\nof O\nRuch B-ORG\nand O\nFrench B-MISC\nPresident O\nJacques B-PER\nChirac I-PER\nis O\nlikely O\nto O\nsupport O\nits O\ncase O\nwhen O\nhe O\nvisits O\nPoland B-LOC\nin O\nSeptember O\n, O\nthe O\ndaily O\nsaid O\n. O\n\nNews-stand O\nchain O\nRuch B-ORG\n, O\nwhich O\ncontrols O\nabout O\n65 O\npercent O\nof O\nPoland B-LOC\n's O\npress O\ndistribution O\nmarket O\n, O\nhad O\na O\nnet O\nprofit O\nof O\n16.2 O\nmillion O\nzlotys O\non O\nsales O\nof O\n2.7 O\nbillion O\nzlotys O\nin O\n1995 O\n. O\n\nIt O\nhas O\nabout O\n17,000 O\nnews-stands O\nand O\nwas O\nthe O\ncountry O\n's O\nsole O\npress O\ndistributor O\nbefore O\nthe O\n1989 O\nfall O\nof O\ncommunism O\n. O\n\nZycie B-ORG\nWarszawy I-ORG\nsaid O\nthe O\nnew O\n, O\nopen O\nconsortium O\n, O\nwhich O\nalso O\nincluded O\nseveral O\nlisted O\nPolish B-MISC\nfirms O\n, O\nwould O\non O\nMonday O\ninform O\nPrivatisation O\nMinister O\nWieslaw B-PER\nKaczmarek I-PER\nof O\nits O\nplans O\n. O\n\nIt O\naims O\nto O\ninvest O\n$ O\n200 O\nmillion O\nin O\nRuch B-ORG\nover O\nfive O\nyears O\n-- O\nmore O\nthan O\nthe O\nsum O\nRuch B-ORG\nsays O\nit O\nneeds O\nto O\nupgrade O\nits O\noutlets O\n. O\n\nInitially O\nPoland B-LOC\noffered O\nup O\nto O\n75 O\npercent O\nof O\nRuch B-ORG\nbut O\nin O\nMarch O\nKaczmarek B-PER\ncancelled O\nthe O\ntender O\nand O\noffered O\na O\nminority O\nstake O\nwith O\nan O\noption O\nto O\nincrease O\nthe O\nequity O\n. O\n\nTwo O\nconsortia O\n-- O\nUWP-Hachette B-ORG\nand O\na O\nconsortium O\nof O\na O\nPolish B-MISC\nSPC B-ORG\ngroup O\nand O\nSwiss B-MISC\nfirms O\n-- O\nplaced O\ninitial O\nbids O\n. O\n\nBut O\nafter O\nthe O\nchange O\nof O\ntender O\nconditions O\nSwiss B-MISC\ninvestors O\npulled O\nout O\nand O\nSPC B-ORG\ndecided O\nto O\nbid O\njointly O\nwith O\nUWP-Hachette B-ORG\n. O\n\nKaczmarek B-PER\nsaid O\nin O\nMay O\nhe O\nwas O\nunhappy O\nthat O\nonly O\none O\ninvestor O\nended O\nup O\nbidding O\nfor O\nRuch B-ORG\n, O\nin O\nwhich O\nthe O\ngovernment O\nwas O\ninitially O\noffering O\nup O\nto O\n35 O\npercent O\nof O\nshares O\nwith O\nan O\noption O\nto O\nextend O\nthe O\nholding O\nafter O\ninvestment O\npromises O\nare O\nfulfilled O\n. O\n\n-- O\nAnthony B-PER\nBarker I-PER\n+48 O\n22 O\n653 O\n9700 O\n\n-DOCSTART- O\n\nThree O\nRussian B-MISC\nsoldiers O\nkilled O\nin O\ngun O\nattack O\n. O\n\nMOSCOW B-LOC\n1996-08-31 O\n\nThree O\nRussian B-MISC\nservicemen O\nwere O\nkilled O\non O\nSaturday O\nwhen O\nunidentified O\ngunmen O\nattacked O\nguards O\nat O\nan O\nanti-aircraft O\ninstallation O\noutside O\nMoscow B-LOC\n, O\nInterfax B-ORG\nnews O\nagency O\nsaid O\n. O\n\nIt O\nquoted O\nmilitary O\nofficials O\nas O\nsaying O\nthe O\nattack O\ntook O\nplace O\nin O\nSergiyev B-LOC\nPosad I-LOC\n70 O\nkm O\n( O\n45 O\nmiles O\n) O\nfrom O\nthe O\ncapital O\n. O\n\nThe O\nofficials O\nsaid O\nthe O\nattackers O\nhad O\nseized O\ntwo O\nKalashnikov B-MISC\nassault O\nrifles O\nand O\ndisappeared O\n. O\n\nAttacks O\non O\nservicemen O\naimed O\nat O\nseizing O\ntheir O\nguns O\nhave O\nbecome O\nfrequent O\nin O\nRussia B-LOC\nwhere O\nthe O\nnumber O\nof O\nviolent O\ncrimes O\ncommitted O\nwith O\nthe O\nuse O\nof O\nfire O\narms O\nis O\ngrowing O\n. O\n\n-DOCSTART- O\n\nCuban B-MISC\nnovelist O\nJose B-PER\nSoler I-PER\nPuig I-PER\ndies O\nat O\n79 O\n. O\n\nHAVANA B-LOC\n1996-08-31 O\n\nOne O\nof O\nCuba B-LOC\n's O\nmost O\nacclaimed O\nauthors O\n, O\nJose B-PER\nSoler I-PER\nPuig I-PER\n, O\ndied O\nat O\nthe O\nage O\nof O\n79 O\n, O\nthe O\nofficial O\nnewspaper O\nGranma B-ORG\nreported O\non O\nSaturday O\n. O\n\nPuig B-PER\n's O\nfirst O\nnovel O\n, O\n\" O\nBertillon B-MISC\n166 I-MISC\n, O\n\" O\nwas O\npublished O\nin O\n1960 O\n, O\na O\nyear O\nafter O\nthe O\nCuban B-MISC\nrevolution O\nbrought O\nPresident O\nFidel B-PER\nCastro I-PER\nto O\npower O\n. O\n\nThe O\nbook O\n, O\nwhich O\nhas O\nbeen O\ntranslated O\ninto O\n40 O\nlanguages O\n, O\ndeals O\nwith O\na O\nday O\nin O\nthe O\nlife O\nof O\nSantiago B-LOC\nde I-LOC\nCuba I-LOC\n, O\nPuig B-PER\n's O\nnative O\ncity O\n, O\nunder O\nthe O\npre-Castro B-MISC\ngovernment O\nof O\nFulgencio B-PER\nBatista I-PER\n. O\n\nThe O\ntitles O\nof O\nhis O\nother O\nnovels O\ntranslate O\nas O\n\" O\nIn B-MISC\nthe I-MISC\nYear I-MISC\nof I-MISC\nJanuary I-MISC\n\" O\n( O\n1963 O\n) O\n, O\n\" O\nThe B-MISC\nCollapse I-MISC\n\" O\n( O\n1964 O\n) O\n, O\n\" O\nSleeping B-MISC\nBread I-MISC\n\" O\n( O\n1975 O\n) O\n, O\n\" O\nThe B-MISC\nDecaying I-MISC\nMansion I-MISC\n\" O\n( O\n1977 O\n) O\nand O\n\" O\nA B-MISC\nWorld I-MISC\nof I-MISC\nThings I-MISC\n\" O\n( O\n1982 O\n) O\n, O\nfollowed O\nby O\n\" O\nThe B-MISC\nKnot I-MISC\n, O\n\" O\n\" O\nSoul B-MISC\nAlone I-MISC\n\" O\nand O\n, O\nmost O\nrecently O\n, O\n\" O\nA B-MISC\nWoman I-MISC\n. O\n\" O\n\nGranma B-ORG\ncalled O\n\" O\nSleeping B-MISC\nBread I-MISC\n\" O\nPuig B-PER\n's O\n\" O\ngreatest O\ngift O\nto O\nthe O\nmodern O\nnovel O\nin O\nour O\nAmerica B-LOC\n. O\n\" O\n\nThe O\nauthor O\nsaid O\nin O\nan O\ninterview O\nshortly O\nbefore O\nhis O\ndeath O\nthat O\nhis O\nown O\nexperiences O\nhad O\nlent O\nhis O\nbooks O\ntheir O\nstrong O\nsense O\nof O\nrealism O\n. O\n\" O\n\nI O\n'm O\na O\nthief O\nof O\nideas O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nThe O\nstories O\nhave O\nbeen O\ngiven O\nto O\nme O\nby O\npeople O\n. O\n\" O\n\nIn O\nthe O\nsame O\ninterview O\n, O\npublished O\nby O\nPrensa B-ORG\nLatina I-ORG\non O\nSaturday O\n, O\nPuig B-PER\nwas O\nasked O\nif O\nhe O\nfeared O\ndeath O\n. O\n\" O\n\nDeath O\nis O\nnot O\na O\npunishment O\n-- O\ndeath O\nis O\nthe O\nend O\nof O\nlife O\n's O\npunishment O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nU.N. B-ORG\nAmbassador O\nAlbright B-PER\narrives O\nin O\nChile B-LOC\n. O\n\nSANTIAGO B-PER\n1996-08-31 O\n\nThe O\nU.S. B-LOC\nambassador O\nto O\nthe O\nUnited B-ORG\nNations I-ORG\n, O\nMadeleine B-PER\nAlbright I-PER\n, O\narrived O\nin O\nChile B-LOC\nlate O\nFriday O\nfor O\ntalks O\non O\nvarious O\nSecurity B-ORG\nCouncil I-ORG\nissues O\nwith O\nChilean B-MISC\nofficials O\nas O\npart O\nof O\na O\nfive-nation O\nLatin B-MISC\nAmerican I-MISC\ntour O\n. O\n\nAlbright B-PER\nwill O\nmeet O\nForeign O\nMinister O\nJose B-PER\nMiguel I-PER\nInsulza I-PER\nMonday O\nfor O\ntalks O\non O\nissues O\ncurrently O\nup O\nfor O\ndebate O\non O\nthe O\ncouncil O\n, O\nof O\nwhich O\nChile B-LOC\nis O\na O\nnon-permanent O\nmember O\n, O\na O\nU.S. B-LOC\nembassy O\nstatement O\nsaid O\n. O\n\nThe O\ntwo O\nwill O\nalso O\ndiscuss O\nvarious O\nissues O\naffecting O\nrelations O\nbetween O\nthe O\nUnited B-LOC\nStates I-LOC\nand O\nChile B-LOC\n, O\nlocal O\nofficials O\nsaid O\n. O\n\nAlbright B-PER\n, O\nwho O\narrived O\nfrom O\nUruguay B-LOC\n, O\nwill O\nrest O\nmost O\nof O\nthe O\nweekend O\nin O\nChile B-LOC\n, O\nofficials O\nsaid O\n. O\n\nHer O\nofficial O\nprogramme O\nwill O\nbegin O\non O\nMonday O\n, O\nand O\nshe O\nwill O\nleave O\nthat O\nday O\nfor O\nBolivia B-LOC\nto O\nattend O\na O\nLatin B-MISC\nAmerican I-MISC\nsummit O\nmeeting O\nin O\nthe O\ncity O\nof O\nCochabamba B-LOC\n. O\n\nHer O\ntour O\nwill O\nalso O\ninclude O\nHonduras B-LOC\nand O\nGuatemala B-LOC\n. O\n\n-DOCSTART- O\n\nMexican B-MISC\narmy O\nattacked O\nin O\nMichoacan B-LOC\nstate O\n- O\nreport O\n. O\n\nMEXICO B-LOC\nCITY I-LOC\n1996-08-30 O\n\nA O\ngroup O\nof O\nheavily-armed O\nmen O\nattacked O\na O\nmilitary O\nconvoy O\nin O\nthe O\nwestern O\nMexican B-MISC\nstate O\nof O\nMichoacan B-LOC\non O\nFriday O\n, O\nkilling O\none O\nsoldier O\nand O\nwounding O\ntwo O\n, O\nradio O\nreports O\nsaid O\n. O\n\nRadio B-ORG\nRed I-ORG\nquoted O\nlocal O\npolice O\nin O\nthe O\ntown O\nof O\nTacambaro B-LOC\n, O\nMichoacan B-LOC\n, O\n80 O\nkm O\n( O\n50 O\nmiles O\n) O\nsouth O\nof O\nthe O\nstate O\ncapital O\nMorelia B-LOC\n, O\nas O\nsaying O\n40 O\nto O\n50 O\narmed O\nmen O\nattacked O\nthe O\nconvoy O\n. O\n\nGonzalo B-PER\nMontoya I-PER\n, O\na O\npolice O\ncommander O\nin O\nTacambaro B-LOC\n, O\ntold O\nRadio B-ORG\nRed I-ORG\nthe O\ngroup O\nwas O\narmed O\nwith O\nAK-47s B-MISC\nand O\nother O\nhigh-powered O\nassault O\nrifles O\nand O\nwore O\nmilitary-style O\nfatigues O\n. O\n\nMontoya B-PER\nsaid O\nhe O\nthought O\nthe O\nattackers O\nwere O\ncriminals O\nlinked O\nto O\ndrug O\ntrafficking O\nor O\nkidnapping O\nin O\nthe O\narea O\n. O\n\" O\n\nWe O\noften O\nsee O\npeople O\ndressed O\nin O\nmilitary-style O\nclothing O\nhere O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\nattack O\ncomes O\na O\nday O\nafter O\nrebels O\nof O\nthe O\nself-styled O\nPopular B-ORG\nRevolutionary I-ORG\nArmy I-ORG\n( O\nEPR B-ORG\n) O\nlaunched O\ncoordinated O\nattacks O\nin O\nat O\nleast O\nthree O\nMexican B-MISC\nstates O\n, O\nkilling O\nup O\nto O\n14 O\npeople O\nand O\nwounding O\nabout O\n20 O\n. O\n\n-DOCSTART- O\n\nChina B-LOC\nsaid O\nto O\nfear O\ndissidents O\nmore O\nthan O\ncriminals O\n. O\n\nMANILA B-LOC\n1996-08-31 O\n\nThe O\ndetention O\nof O\nveteran O\ndissident O\nWang B-PER\nDonghai I-PER\nshowed O\nChina B-LOC\n's O\ndetermination O\nto O\ncrush O\nany O\nvestige O\nof O\ndissent O\nduring O\nthe O\ncurrent O\nprofound O\ntransitions O\nin O\nthe O\nnation O\n's O\nleadership O\n, O\na O\nhuman O\nrights O\nactivist O\nsaid O\non O\nSaturday O\n. O\n\nXiao B-PER\nQiang I-PER\n, O\nexecutive O\ndirector O\nof O\nthe O\nNew B-MISC\nYork-based I-MISC\ngroup O\nHuman B-ORG\nRights I-ORG\nin I-ORG\nChina I-ORG\n, O\nsaid O\nWang B-PER\n's O\narrest O\non O\nFriday O\nappeared O\nto O\nbe O\npart O\nof O\nthe O\nnational O\n\" O\nStrike B-MISC\nHard I-MISC\n\" O\ncampaign O\nthat O\nhas O\nimprisoned O\nthousands O\nand O\nsent O\nhundreds O\nto O\ntheir O\ndeath O\n. O\n\nAlthough O\nsupposedly O\naimed O\nat O\ncriminals O\n, O\ndozens O\nof O\nhuman O\nrights O\nactivists O\nhave O\nbeen O\ndetained O\nin O\nthe O\ncampaign O\n, O\nwhich O\nis O\nmeant O\nto O\nstrengthen O\nthe O\nCommunist B-ORG\nParty I-ORG\n's O\ngrip O\non O\npower O\nas O\nsenior O\nleader O\nDeng B-PER\nXiaoping I-PER\nnears O\ndeath O\n, O\nXiao B-PER\nsaid O\nin O\nan O\ninterview O\n. O\n\n\" O\nChina B-LOC\nis O\ngoing O\nthrough O\nthis O\npower O\ntransition O\nperiod O\n. O\n\nThe O\nauthorities O\nare O\napparently O\nextremely O\nafraid O\nof O\nany O\npolitical O\nand O\nsocial O\ndiscontent O\n, O\n\" O\nsaid O\nXiao B-PER\n, O\nin O\nManila B-LOC\nto O\nattend O\nan O\nAmnesty B-ORG\nInternational I-ORG\nconference O\non O\nhuman O\nrights O\nin O\nChina B-LOC\n. O\n\nHe O\nsaid O\none O\nof O\nWang B-PER\n's O\napparent O\noffences O\nwas O\nto O\nwrite O\na O\npublic O\nletter O\nin O\nMay O\nsuggesting O\nthat O\na O\nfree O\npress O\nand O\nan O\nindependent O\njudicial O\nsystem O\nwere O\nvital O\nif O\nthe O\ngovernment O\nreally O\nmeant O\nto O\nstamp O\nout O\nrampant O\ncorruption O\n. O\n\nXiao B-PER\nsaid O\ncrushing O\nlegitimate O\ndissent O\nwas O\nonly O\nmaking O\nthe O\nproblem O\nworse O\nand O\none O\nday O\nChina B-LOC\nwould O\npay O\na O\nhigh O\nprice O\n. O\n\n\" O\nThose O\nissues O\nare O\nnot O\ngoing O\nto O\ngo O\naway O\nby O\nrepression O\n. O\n\nYou O\nonly O\nmake O\nthings O\nmore O\nhidden O\nbut O\npotentially O\nmore O\nexplosive O\n, O\n\" O\nhe O\nsaid O\n. O\n\nWang B-PER\nwas O\narrested O\nin O\nthe O\neast O\nChina B-LOC\ncity O\nof O\nHangzhou B-LOC\nby O\nsecurity O\nofficers O\nwho O\ntold O\nthe O\ndissident O\n's O\nfamily O\nhe O\nwould O\nbe O\nsent O\nto O\na O\nstudy O\nclass O\n-- O\na O\neuphemism O\nfor O\ncoercive O\nideological O\nreform O\n. O\n\nWang B-PER\n, O\n45 O\n, O\nwas O\nsentenced O\nlast O\nmonth O\nto O\none O\nyear O\n's O\n\" O\nre-education O\nby O\nlabour O\n\" O\nbut O\nwas O\nreleased O\nbecause O\nof O\nill-health O\n. O\n\nXiao B-PER\nsaid O\nconditions O\nin O\nthe O\nlabour O\ncamp O\nwere O\nso O\nbrutal O\nthey O\ndrove O\nanother O\nactivist O\nsentenced O\nwith O\nWang B-PER\nto O\nattempt O\nsuicide O\n. O\n\nPolice O\nbeat O\nWang B-PER\nand O\nhis O\ncolleague O\n, O\nChen B-PER\nLongde I-PER\n, O\nand O\nencouraged O\nother O\ncamp O\ninmates O\nto O\nattack O\nthem O\nas O\nwell O\n, O\nXiao B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nManila B-LOC\nhails O\nIndonesia B-LOC\n, O\nOIC B-ORG\nfor O\npeace O\ndeal O\nsupport O\n. O\n\nMANILA B-LOC\n1996-08-31 O\n\nPhilippine B-LOC\npresident O\nFidel B-PER\nRamos I-PER\nexpressed O\ngratitude O\nto O\nIndonesian B-MISC\npresident O\nSuharto B-PER\nand O\nthe O\nOrganisation B-ORG\nof I-ORG\nIslamic I-ORG\nConference I-ORG\n( O\nOIC B-ORG\n) O\non O\nSaturday O\nfor O\nsupporting O\ntalks O\nthat O\nended O\na O\nconflict O\nwith O\nlocal O\nMoslem B-MISC\nrebels O\n. O\n\n\" O\nI O\nextend O\nthe O\ndeepest O\ngratitude O\n... O\nto O\nyour O\nexcellency O\nfor O\nyour O\nuntiring O\nand O\ninvaluable O\nfriendship O\nand O\nsupport O\n, O\n\" O\nRamos B-PER\ntold O\nSuharto B-PER\nin O\na O\nletter O\n. O\n\nThe O\nfull O\ntext O\nof O\nthe O\nletter O\nwas O\nreleased O\nto O\nreporters O\non O\nSaturday O\n. O\n\nJakarta B-LOC\nserved O\nas O\nthe O\nhost O\nto O\nthe O\nseries O\nof O\nnegotiations O\nwhich O\nculminated O\nin O\nthe O\ninitialling O\nof O\nthe O\nagreement O\nlast O\nFriday O\n. O\n\nThe O\nformal O\nsigning O\nof O\nthe O\npeace O\nagreement O\nis O\nscheduled O\non O\nMonday O\nin O\nManila B-LOC\n. O\n\nRamos B-PER\nsaid O\nthe O\npeace O\nagreement O\n\" O\nshall O\nbring O\ndown O\nthe O\ncurtain O\non O\na O\nlong O\nand O\nstoried O\nera O\nof O\nstrife O\nin O\nPhilippine B-LOC\nhistory O\n. O\n\" O\n\nThe O\nwar O\nclaimed O\nmore O\nthan O\n125,000 O\nlives O\nin O\nthe O\nsouthern O\nMindanao B-LOC\nisland O\nover O\na O\nquarter O\nof O\na O\ncentury O\n. O\n\n-DOCSTART- O\n\nBurma B-LOC\n's O\nSuu B-PER\nKyi I-PER\nsays O\nmilitary O\nrulers O\nabuse O\nlaw O\n. O\n\nDeborah B-PER\nCharles I-PER\n\nRANGOON B-LOC\n1996-08-31 O\n\nBurma B-LOC\n's O\ndemocracy O\nleader O\nAung B-PER\nSan I-PER\nSuu I-PER\nKyi I-PER\nhit O\nout O\nat O\nthe O\ngovernment O\non O\nSaturday O\nfor O\nrecent O\narrests O\nand O\njailing O\nof O\nactivists O\n, O\nsaying O\nthe O\nmilitary O\nabused O\nthe O\nlaw O\nto O\ntry O\nto O\ncrush O\nthe O\ndemocracy O\nmovement O\n. O\n\n\" O\nThe O\nmain O\npurpose O\nof O\nthis O\npress O\nconference O\nis O\nto O\nmake O\nit O\nknown O\nto O\nthe O\nworld O\nthat O\nthe O\nauthorities O\nare O\nmisusing O\nthe O\nlaw O\nall O\nthe O\ntime O\nin O\norder O\nto O\ntry O\nto O\ncrush O\nthe O\ndemocracy O\nmovement O\n, O\n\" O\nSuu B-PER\nKyi I-PER\ntold O\nreporters O\nat O\nher O\nRangoon B-LOC\nhome O\n. O\n\nSuu B-PER\nKyi I-PER\nsaid O\nat O\nleast O\n61 O\ndemocracy O\nsupporters O\nhad O\nbeen O\narrested O\nsince O\nMay O\n, O\nand O\nabout O\n30 O\nof O\nthem O\nhad O\nbeen O\nsentenced O\n, O\nmost O\nto O\nlong O\nprison O\nterms O\n. O\n\nIn O\nMay O\nthe O\ngovernment O\nlaunched O\na O\nsweeping O\ncrackdown O\non O\nthe O\ndemocracy O\nmovement O\n, O\ndetaining O\nover O\n260 O\nmembers O\nof O\nSuu B-PER\nKyi I-PER\n's O\nNational B-ORG\nLeague I-ORG\nfor I-ORG\nDemocracy I-ORG\n( O\nNLD B-ORG\n) O\nahead O\nof O\na O\nparty O\ncongress O\n. O\n\nMost O\nwere O\nreleased O\nbut O\nseveral O\ndozen O\nremain O\nin O\ncustody O\n. O\n\nThe O\nBurmese B-MISC\ngovernment O\nlast O\nweek O\nconfirmed O\nthe O\nrecent O\nsentencing O\nof O\nnine O\ndemocracy O\nactivists O\nwho O\nwere O\narrested O\nin O\nthe O\nMay O\ncrackdown O\n, O\nincluding O\nSuu B-PER\nKyi I-PER\n's O\nassistant O\nWin B-PER\nHtein I-PER\n. O\n\nThe O\nmilitary O\ngovernment O\n, O\nwhich O\nin O\nMay O\nsaid O\nit O\nhad O\ndetained O\nthe O\npoliticians O\nto O\nprevent O\nanarchy O\n, O\nsaid O\nthe O\nactivists O\nwere O\ncharged O\nwith O\nattempting O\nto O\ndestroy O\nthe O\npeace O\nand O\nstability O\nof O\nthe O\nstate O\n. O\n\nBut O\nSuu B-PER\nKyi I-PER\ndisagreed O\nwith O\nthe O\nmethods O\n, O\nsaying O\nofficials O\noften O\narrested O\nNLD B-ORG\nsupporters O\nin O\nthe O\nmiddle O\nof O\nthe O\nnight O\n, O\nthen O\ndid O\nnot O\ngive O\nthem O\nthe O\nopportunity O\nto O\ndefend O\nthemselves O\nin O\ntrials O\n. O\n\n\" O\nWhen O\nour O\npeople O\nare O\ntried O\n, O\nthey O\nare O\ntried O\nin O\na O\nvery O\nsecretive O\nway O\n. O\n\nTheir O\nfamilies O\nare O\nnot O\ntold O\n, O\n\" O\nshe O\nsaid O\n. O\n\nSuu B-PER\nKyi I-PER\n, O\nwho O\nspearheads O\na O\ncampaign O\nfor O\nsanctions O\non O\nBurma B-LOC\n's O\ngovernment O\n, O\nwas O\nunder O\nhouse O\narrest O\nfor O\nsix O\nyears O\nwithout O\nbeing O\ntried O\nbefore O\nbeing O\nreleased O\nin O\nJuly O\n1995 O\n. O\n\nSeveral O\nother O\nleading O\nmembers O\nof O\nthe O\nNLD B-ORG\nhave O\nserved O\nprison O\nterms O\n. O\n\nThe O\nNLD B-ORG\nparty O\nwon O\na O\nlandslide O\nvictory O\nin O\na O\n1990 O\nelection O\nbut O\nthe O\nState B-ORG\nLaw I-ORG\nand I-ORG\nOrder I-ORG\nRestoration I-ORG\nCouncil I-ORG\n( O\nSLORC B-ORG\n) O\n, O\nwhich O\nassumed O\npower O\nin O\n1988 O\nafter O\ncrushing O\npro-democracy O\ndemonstrations O\n, O\nnever O\nrecognised O\nthe O\npoll O\n. O\n\n\" O\nThis O\nlack O\nof O\nrule O\nof O\nlaw O\nis O\nan O\nindication O\nthat O\nthe O\nauthorities O\nare O\nnot O\ninterested O\nin O\nfair O\nplay O\n, O\n\" O\nshe O\nsaid O\n. O\n\" O\n\nThey O\nare O\nusing O\na O\ntravesty O\nof O\nthe O\nlaw O\nto O\ntry O\nand O\ncrush O\nour O\nmovements O\nand O\nto O\nsentence O\nour O\npeople O\nto O\nlong O\nterms O\nin O\nprison O\nwithout O\nproper O\ntrial O\n. O\n\" O\n\nSuu B-PER\nKyi I-PER\nsaid O\nonce O\nthe O\nactivists O\nwere O\nsentenced O\n, O\nthey O\nsuffered O\ninhuman O\nconditions O\nand O\nlack O\nof O\nrights O\nin O\nprison O\n. O\n\n\" O\nAlmost O\nall O\nof O\nthe O\nprisoners O\nstart O\nsuffering O\nfrom O\nvarious O\nhealth O\nproblems O\nafter O\na O\ncouple O\nof O\nyears O\nin O\njail O\n, O\n\" O\nshe O\nsaid O\n. O\n\" O\n\nSome O\nof O\nour O\npeople O\nhave O\nbeen O\nin O\nprison O\nfor O\nfive O\nto O\nsix O\nyears O\n. O\n\" O\n\nMost O\npolitical O\nprisoners O\nare O\nheld O\nin O\nRangoon B-LOC\n's O\nInsein B-LOC\nPrison I-LOC\n. O\n\nSome O\nwho O\nhave O\nbeen O\nreleased O\nhave O\nrecounted O\ntorture O\nmethods O\nlike O\nsleep O\nand O\nfood O\ndeprivation O\nand O\nphysical O\nabuse O\n. O\n\n\" O\nIf O\nthere O\nare O\nany O\nmore O\ninstances O\nof O\ndeath O\nin O\ncustody O\nit O\nwill O\nbe O\nfurther O\nproof O\nthat O\na O\nprison O\nsentence O\nfor O\npolitical O\nprisoners O\nis O\nsometimes O\nalmost O\nthe O\nsame O\nas O\na O\ndeath O\nsentence O\n, O\n\" O\nSuu B-PER\nKyi I-PER\nsaid O\n. O\n\nHla B-PER\nThan I-PER\n, O\nan O\nelected O\nmember O\nof O\nparliament O\nfor O\nthe O\nNLD B-ORG\n, O\ndied O\nin O\nearly O\nAugust O\nafter O\nbeing O\nat O\nInsein B-LOC\nfor O\nsix O\nyears O\n. O\n\nHis O\ndeath O\ncame O\nfive O\nweeks O\nafter O\nJames B-PER\nLeander I-PER\n( I-PER\nLeo I-PER\n) I-PER\nNichols I-PER\n, O\na O\nclose O\nfriend O\nof O\nSuu B-PER\nKyi I-PER\nand O\nDanish B-MISC\nhonorary O\nconsul O\n, O\ndied O\nwhile O\nserving O\na O\nprison O\nterm O\nat O\nInsein B-LOC\n. O\n\nSuu B-PER\nKyi I-PER\nsaid O\nthe O\ngovernment O\nhad O\nincreased O\nits O\nrepression O\ntactics O\non O\nthe O\ndemocracy O\nmovement O\nbecause O\nit O\nfeared O\nthe O\ngrowing O\npopularity O\nof O\nthe O\nmovement O\n. O\n\nBut O\nshe O\nsaid O\nshe O\nand O\nthe O\nNLD B-ORG\nwould O\nnot O\nstop O\ntheir O\nefforts O\nto O\nbring O\ndemocracy O\nto O\nBurma B-LOC\neven O\nif O\nit O\nmeant O\nmore O\narrests O\nof O\nparty O\nmembers O\nor O\neven O\nherself O\n. O\n\n\" O\nWe O\nwill O\ncarry O\non O\n. O\n\nNobody O\nis O\nfree O\nfrom O\narrest O\nin O\nBurma B-LOC\n. O\n\" O\n\n-DOCSTART- O\n\nDow B-ORG\nChemical I-ORG\nin O\nChina B-LOC\nethylene O\nventure O\n. O\n\nBEIJING B-LOC\n1996-08-31 O\n\nThe O\nDow B-ORG\nChemical I-ORG\nCo I-ORG\nof O\nthe O\nUnited B-LOC\nStates I-LOC\nwill O\ninvest O\n$ O\n4 O\nbillion O\nto O\nbuild O\nan O\nethylene O\nplant O\nin O\nTianjin B-LOC\ncity O\nin O\nnorthern O\nChina B-LOC\n, O\nthe O\nChina B-ORG\nDaily I-ORG\nsaid O\non O\nSaturday O\n. O\n\nThe O\nplant O\nwill O\nhave O\nannual O\nproduction O\nof O\n400,000 O\ntonnes O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nIt O\ngave O\nno O\nfurther O\ndetails O\nof O\nthe O\nventure O\n. O\n\nTianjin B-LOC\nboasts O\na O\nrange O\nof O\ninfrastructure O\nfacilities O\n, O\nattracting O\nseveral O\nmultinational O\noil O\ncompanies O\nto O\ninvest O\nin O\nrecent O\nyears O\n. O\n\nCaltex B-ORG\nPetroleum I-ORG\nCorp I-ORG\nplans O\nto O\nbuild O\na O\nlubricants O\nblender O\nin O\na O\nbonded O\nzone O\nin O\nTianjin B-LOC\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nMultinational O\nfirms O\nincluding O\nMobil B-ORG\n, O\nShell B-ORG\nand O\nCaltex B-ORG\n, O\nwere O\nalso O\nattracted O\nto O\nTianjin B-LOC\ndue O\nto O\nChina B-LOC\n's O\nrising O\ndemand O\nfor O\nlube O\nand O\noil-based O\nproducts O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nIt O\ngave O\nno O\nfurther O\ndetails O\n. O\n\n-DOCSTART- O\n\nN. B-LOC\nKorea I-LOC\nurges O\nS. B-LOC\nKorea I-LOC\nto O\nreturn O\nwar O\nveteran O\n. O\n\nSEOUL B-LOC\n1996-08-31 O\n\nNorth B-LOC\nKorea I-LOC\ndemanded O\non O\nSaturday O\nthat O\nSouth B-LOC\nKorea I-LOC\nreturn O\na O\nnorthern O\nwar O\nveteran O\nwho O\nhas O\nbeen O\nin O\nthe O\nSouth B-LOC\nsince O\nthe O\n1950-53 O\nwar O\n, O\nSeoul B-LOC\n's O\nunification O\nministry O\nsaid O\n. O\n\n\" O\n...I O\nrequest O\nthe O\nimmediate O\nrepatriation O\nof O\nKim B-PER\nIn-so I-PER\nto O\nNorth B-LOC\nKorea I-LOC\nwhere O\nhis O\nfamily O\nis O\nwaiting O\n, O\n\" O\nNorth B-ORG\nKorean I-ORG\nRed I-ORG\nCross I-ORG\npresident O\nLi B-PER\nSong-ho I-PER\nsaid O\nin O\na O\ntelephone O\nmessage O\nto O\nhis O\nsouthern O\ncouterpart O\n, O\nKang B-PER\nYoung-hoon I-PER\n. O\n\nLi B-PER\nsaid O\nKim B-PER\nhad O\nbeen O\ncritically O\nill O\nwith O\na O\ncerebral O\nhaemorrhage O\n. O\n\nThe O\nmessage O\nwas O\ndistributed O\nto O\nthe O\npress O\nby O\nthe O\nSouth B-MISC\nKorean I-MISC\nunification O\nministry O\n. O\n\nKim B-PER\n, O\nan O\nunrepentant O\ncommunist O\n, O\nwas O\ncaptured O\nduring O\nthe O\nKorean B-MISC\nWar O\nand O\nreleased O\nafter O\nspending O\nmore O\nthan O\n30 O\nyears O\nin O\na O\nsouthern O\njail O\n. O\n\nHe O\nsubmitted O\na O\npetition O\nto O\nthe O\nInternational B-ORG\nRed I-ORG\nCross I-ORG\nin O\n1993 O\nasking O\nfor O\nhis O\nrepatriation O\n. O\n\nThe O\ndomestic O\nYonhap B-ORG\nnews O\nagency O\nsaid O\nthe O\nSouth B-MISC\nKorean I-MISC\ngovernment O\nwould O\nconsider O\nthe O\nnorthern O\ndemand O\nonly O\nif O\nthe O\nNorth B-LOC\naccepted O\nSeoul B-LOC\n's O\nrequests O\n, O\nwhich O\ninclude O\nregular O\nreunions O\nof O\nfamilies O\nsplit O\nby O\nthe O\nKorean B-MISC\nWar O\n. O\n\nGovernment O\nofficials O\nwere O\nnot O\navailable O\nto O\ncomment O\n. O\n\nSouth B-LOC\nKorea I-LOC\nin O\n1993 O\nunconditionally O\nrepatriated O\nLi B-PER\nIn-mo I-PER\n, O\na O\nnothern O\npartisan O\nseized O\nby O\nthe O\nSouth B-LOC\nduring O\nthe O\nwar O\nand O\njailed O\nfor O\nmore O\nthan O\nthree O\ndecades O\n. O\n\n-DOCSTART- O\n\nChinese B-MISC\npolice O\nhold O\nveteran O\ndissident O\n. O\n\nBEIJING B-LOC\n1996-08-31 O\n\nChinese B-MISC\npolice O\nhave O\ndetained O\nveteran O\ndissident O\nWang B-PER\nDonghai I-PER\n, O\nthe O\nNew B-MISC\nYork-based I-MISC\npressure O\ngroup O\nHuman B-ORG\nRights I-ORG\nin I-ORG\nChina I-ORG\nsaid O\non O\nSaturday O\n. O\n\nPolice O\nin O\nHangzhou B-LOC\n, O\ncapital O\nof O\nthe O\neastern O\nprovince O\nof O\nZhejiang B-LOC\n, O\ntold O\nWang B-PER\n's O\nfamily O\nthat O\nWang B-PER\nwould O\nbe O\nsent O\nto O\na O\nstudy O\nclass O\n, O\na O\neuphemism O\nfor O\ncoercive O\nideological O\nreform O\n, O\nthe O\ngroup O\nsaid O\n. O\n\nPolice O\ngave O\nno O\nreason O\nfor O\ndetaining O\nWang B-PER\non O\nFriday O\nand O\nwould O\nnot O\nlet O\nhis O\nfamily O\nmeet O\nhim O\nor O\nsay O\nwhere O\nhe O\nwas O\nbeing O\nheld O\n, O\nthe O\ngroup O\nsaid O\n. O\n\nPolice O\nalso O\nwould O\nnot O\nsay O\nwhy O\nWang B-PER\nwas O\nbeing O\nsent O\nto O\na O\nstudy O\nclass O\n-- O\na O\nholdover O\nfrom O\nthe O\nchaotic O\n1966-76 B-MISC\nCultural I-MISC\nRevolution I-MISC\n-- O\nor O\nsay O\nwhen O\nhe O\nwould O\nbe O\nreleased O\n, O\nthe O\ngroup O\nsaid O\n. O\n\nWang B-PER\n's O\nfamily O\nand O\nHangzhou B-LOC\npolice O\ncould O\nnot O\nbe O\nreached O\nfor O\nimmediate O\ncomment O\n. O\n\nThe O\ngroup O\ndemanded O\nWang B-PER\n's O\nrelease O\nand O\nsaid O\nhis O\ndetention O\nwas O\na O\ndangerous O\nsignal O\nChina B-LOC\nwas O\nreturning O\nto O\nits O\nCultural B-MISC\nRevolution I-MISC\ndays O\n. O\n\nLast O\nmonth O\n, O\nWang B-PER\n, O\n45 O\n, O\na O\nveteran O\ndissident O\nof O\nthe O\n1979 O\nDemocracy B-ORG\nWall I-ORG\nmovement O\n, O\nwas O\nordered O\nto O\nserve O\none O\nyear O\nof O\n\" O\nre-education O\nthrough O\nlabour O\n\" O\n, O\nbut O\nreleased O\nbecause O\nof O\npoor O\nhealth O\n. O\n\nRe-education O\nthrough O\nlabour O\nis O\nan O\nadministrative O\npunishment O\nwith O\na O\nmaximum O\nof O\nthree O\nyears O\nthat O\ncan O\nbe O\nimposed O\nby O\npolice O\nwithout O\nrecourse O\nto O\nprosecutors O\nor O\nthe O\ncourts O\n. O\n\nWang B-PER\nwas O\njailed O\nfor O\ntwo O\nyears O\nfor O\norganising O\nstreet O\nprotests O\nafter O\nthe O\nmilitary O\ncrushed O\npro-democracy O\ndemonstrations O\nby O\nstudents O\nat O\nBeijing B-LOC\n's O\nTiananmen B-LOC\nSquare I-LOC\non O\nJune O\n4 O\n, O\n1989 O\n, O\nwith O\nheavy O\nloss O\nof O\nlife O\n. O\n\nChinese B-MISC\nauthorities O\nappeared O\nto O\nbe O\nusing O\nadministrative O\npunishment O\nmore O\nfrequently O\nto O\ntake O\ndissidents O\nout O\nof O\ncirculation O\nwithout O\nhaving O\nto O\ngo O\nthrough O\na O\nmore O\ncomplicated O\njudicial O\nprocess O\nto O\nimpose O\ncriminal O\nsentences O\n, O\nWestern B-MISC\ndiplomats O\nhave O\nsaid O\n. O\n\n-DOCSTART- O\n\nChina B-LOC\npolice O\ndetains O\ndissident O\nWang B-PER\nDonghai I-PER\n. O\n\nBEIJING B-LOC\n1996-08-31 O\n\nChinese B-MISC\npolice O\nhave O\ndetained O\ndissident O\nWang B-PER\nDonghai I-PER\n, O\nthe O\nNew B-MISC\nYork-based I-MISC\npressure O\ngroup O\nHuman B-ORG\nRights I-ORG\nin I-ORG\nChina I-ORG\nsaid O\non O\nSaturday O\n. O\n\nPolice O\ndetained O\nWang B-PER\non O\nFriday O\nand O\nwould O\nnot O\nlet O\nhis O\nfamily O\nmeet O\nhim O\nor O\nsay O\nwhere O\nhe O\nwas O\nbeing O\nheld O\n, O\nthe O\ngroup O\nsaid O\n. O\n\nThe O\npressure O\ngroup O\nsaid O\nWang B-PER\nwould O\nbe O\nsent O\nto O\na O\nstudy O\nclass O\n, O\noften O\na O\neuphemism O\nin O\nChina B-LOC\nfor O\nideological O\nreform O\n. O\n\nWang B-PER\n's O\nfamily O\ncould O\nnot O\nimmediately O\nbe O\nreached O\nfor O\ncomment O\n. O\n\nLast O\nmonth O\n, O\nWang B-PER\n, O\n45 O\n, O\na O\nveteran O\ndissident O\nof O\nthe O\n1979 O\nDemocracy B-ORG\nWall I-ORG\nmovement O\n, O\nwas O\nordered O\nto O\nserve O\none O\nyear O\nof O\n\" O\nre-education O\nthrough O\nlabour O\n\" O\n, O\nbut O\nreleased O\nbecause O\nof O\npoor O\nhealth O\n. O\n\nRe-education O\nthrough O\nlabour O\nis O\nan O\nadministrative O\npunishment O\nwith O\na O\nmaximum O\nof O\nthree O\nyears O\nthat O\ncan O\nbe O\nimposed O\nby O\npolice O\nwithout O\nrecourse O\nto O\nprosecutors O\nor O\nthe O\ncourts O\n. O\n\nWang B-PER\nwas O\njailed O\nfor O\ntwo O\nyears O\nfor O\norganising O\nstreet O\nprotests O\nafter O\nthe O\nmilitary O\nbrutally O\ncrushed O\npro-democracy O\ndemonstrations O\nby O\nstudents O\nat O\nBeijing B-LOC\n's O\nTiananmen B-LOC\nSquare I-LOC\non O\nJune O\n4 O\n, O\n1989 O\n, O\nwith O\nheavy O\nloss O\nof O\nlife O\n. O\n\n-DOCSTART- O\n\nHong B-LOC\nKong I-LOC\njails O\n88-year-old O\ndrug O\ntrafficker O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-31 O\n\nAn O\n88-year-old O\narmy O\nveteran O\nwas O\njailed O\nfor O\n15 O\nyears O\nby O\na O\nHong B-LOC\nKong I-LOC\ncourt O\nfor O\ndrugs O\ntrafficking O\nafter O\nhe O\nadmitted O\nhe O\nhad O\nstashed O\nheroin O\nunder O\nhis O\nmattress O\n, O\na O\nnewspaper O\nsaid O\non O\nSaturday O\n. O\n\n\" O\nI O\nam O\nsorry O\nto O\nmy O\nancestors O\nfor O\nfive O\ngenerations O\n, O\n\" O\nChen B-PER\nChun-yeh I-PER\ntold O\nthe O\nHigh B-ORG\nCourt I-ORG\nafter O\nsentencing O\non O\nFriday O\n, O\nthe O\nHong B-ORG\nKong I-ORG\nStandard I-ORG\nsaid O\n. O\n\" O\n\nTell O\nmy O\nsons O\nto O\ncollect O\nmy O\nbones O\n, O\n\" O\nhe O\nsaid O\nafter O\nhearing O\nhe O\nwas O\nlikely O\nto O\ndie O\nbehind O\nbars O\n. O\n\nChen B-PER\n, O\na O\nformer O\narmy O\nsecretary O\nof O\nthe O\nChinese B-MISC\nNationalist O\nregime O\nwhich O\nfled O\nfrom O\nmainland O\nChina B-LOC\nto O\nTaiwan B-LOC\nin O\n1949 O\n, O\npleaded O\nguilty O\nto O\ntrafficking O\n42 O\nkg O\n( O\n92 O\npounds O\n) O\nof O\ndrugs O\nthat O\ncould O\nhave O\nbeen O\nturned O\ninto O\n25 O\nkg O\n( O\n55 O\npounds O\n) O\nof O\nheroin O\n. O\n\nThe O\nex-officer O\nadmitted O\nstashing O\nheroin O\nunder O\nhis O\nmattress O\n. O\n\n-DOCSTART- O\n\nChina B-LOC\ncities O\nto O\nban O\ndisposable O\nplastic O\ncontainers O\n. O\n\nBEIJING B-LOC\n1996-08-31 O\n\nTwo O\nChinese B-MISC\ncities O\nare O\nto O\nban O\nthe O\nuse O\nof O\ndisposable O\nplastic O\ncontainers O\nas O\npart O\nof O\nefforts O\nto O\nfight O\npollution O\n, O\nthe O\nChina B-ORG\nDaily I-ORG\nsaid O\non O\nSaturday O\n. O\n\nAuthorities O\nin O\nWuhan B-LOC\n, O\ncapital O\nof O\nthe O\ncentral O\nprovince O\nof O\nHubei B-LOC\n, O\nwould O\npunish O\nthose O\nwho O\nsell O\nor O\nuse O\ndisposable O\nplastic O\ncontainers O\nfrom O\nSeptember O\n1 O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nIt O\ndid O\nnot O\nelaborate O\n. O\n\nThe O\ncity O\n's O\nindustrial O\nand O\ncommercial O\ndepartments O\nwould O\nconfiscate O\ndisposable O\nplastic O\ncontainers O\nand O\npolice O\nwould O\nprevent O\nnew O\nones O\nfrom O\nentering O\nthe O\ncity O\n, O\nit O\nsaid O\n. O\n\nWuhan B-LOC\nconsumes O\nmore O\nthan O\n200 O\nmillion O\ndisposable O\nplastic O\ncontainers O\na O\nyear O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nThe O\nboomtown O\nof O\nGuangzhou B-LOC\n, O\ncapital O\nof O\nthe O\nsouthern O\nprovince O\nof O\nGuangdong B-LOC\n, O\nwould O\nban O\ndisposable O\nplastic O\ncontainers O\nby O\nthe O\nend O\nof O\n1996 O\n, O\nit O\nsaid O\n. O\n\nGuangzhou B-LOC\nuses O\nup O\n500,000 O\nsuch O\ncontainers O\neach O\nday O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nIt O\ngave O\nno O\nfurther O\ndetails O\n. O\n\n-DOCSTART- O\n\nIraqi B-MISC\nKurds I-MISC\nsay O\nIranian B-MISC\ntroops O\nenter O\nnorth O\nIraq B-LOC\n. O\n\nISTANBUL B-LOC\n1996-08-31 O\n\nIranian B-MISC\ntroops O\non O\nSaturday O\nentered O\nKurdish-controlled B-MISC\nnorthern O\nIraq B-LOC\nin O\nthe O\nwake O\nof O\nan O\nassault O\nbacked O\nby O\nBaghdad B-LOC\ninto O\nthe O\nregion O\n, O\nan O\nIraqi B-MISC\nKurdish I-MISC\ngroup O\ntold O\nReuters B-ORG\n. O\n\n\" O\nThey O\nentered O\nthis O\nmorning O\n. O\n\nThey O\nhave O\noccupied O\nthe O\narea O\nto O\nthe O\ndepth O\nof O\n40 O\nkm O\n( O\n25 O\nmiles O\n) O\n. O\n\nThey O\nhave O\nestablished O\na O\nheadquarters O\nin O\nChuman B-LOC\n, O\n\" O\nFaik B-PER\nNerweyi I-PER\nof O\nthe O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nKDP B-ORG\n) O\ntold O\nReuters B-ORG\nby O\ntelephone O\nfrom O\nAnkara B-LOC\n. O\n\nNerweyi B-PER\nsaid O\nhe O\ndid O\nnot O\nknow O\nthe O\nsize O\nor O\nnature O\nof O\nthe O\nIranian B-MISC\nforce O\nin O\nnorthern O\nIraq B-LOC\n, O\nbut O\nsaid O\nKDP B-ORG\nfighters O\nhad O\nbeen O\neasily O\noutgunned O\nin O\nthe O\narea O\nclose O\nto O\nthe O\nIranian B-MISC\nborder O\nand O\nhad O\nquickly O\nwithdrawn O\nfurther O\nwest O\n. O\n\n\" O\nThey O\nwere O\nfar O\ntoo O\nstrong O\n, O\n\" O\nhe O\nsaid O\n. O\n\nNerweyi B-PER\nsaid O\nhe O\ndid O\nnot O\nknow O\nif O\nthere O\nwere O\nany O\ncasualties O\n. O\n\nA O\nU.N. B-ORG\nofficial O\nin O\nBaghdad B-LOC\nsaid O\nthe O\nKDP B-ORG\n, O\nbacked O\nby O\nIraqi B-MISC\ntanks O\n, O\nheavy O\nartillery O\nand O\nhelicopters O\nhad O\ntaken O\ncontrol O\nof O\nthe O\nmain O\nnorthern O\nIraqi B-MISC\ncity O\nof O\nArbil B-LOC\nafter O\nfighting O\non O\nSaturday O\n. O\n\nU.S. B-LOC\nPresident O\nBill B-PER\nClinton I-PER\nhas O\nauthorised O\nthe O\nrepositioning O\nof O\nU.S. B-LOC\nfirepower O\nin O\nthe O\nGulf B-LOC\nregion O\nin O\nresponse O\nto O\nthe O\nIraqi B-MISC\nattacks O\n. O\n\nThe O\nKDP B-ORG\ncharges O\nthat O\nthe O\nrival O\nPatriotic B-ORG\nUnion I-ORG\nof I-ORG\nKurdistan I-ORG\n, O\nwhich O\ntook O\ncontrol O\nof O\nArbil B-LOC\nin O\nfighting O\nin O\nDecember O\n1994 O\n, O\nhas O\nbacking O\nfrom O\nIran B-LOC\n. O\n\nThe O\nPUK B-ORG\naccuses O\nthe O\nKDP B-ORG\nof O\ncollaborating O\nwith O\nBaghdad B-LOC\n. O\n\nNorthern O\nIraq B-LOC\nhas O\nbeen O\nunder O\nIraqi B-MISC\nKurdish I-MISC\ncontrol O\nsince O\nafter O\nthe O\n1991 O\nGulf B-MISC\nWar I-MISC\n. O\n\nU.S.-led B-MISC\nallied O\nplanes O\nbased O\nin O\nTurkey B-LOC\nare O\nintended O\nto O\nprotect O\nthe O\nKurds B-MISC\nfrom O\nBaghdad B-LOC\n. O\n\n-DOCSTART- O\n\nCeasefire O\nmonitors O\nto O\nmeet O\nin O\nsouth O\nLebanon B-LOC\n. O\n\nJERUSALEM B-LOC\n1996-08-31 O\n\nA O\ncommittee O\nmonitoring O\nthe O\nceasefire O\nagreement O\nbetween O\nIsrael B-LOC\nand O\nHizbollah B-ORG\nguerrillas O\nwill O\nmeet O\nin O\nsouth O\nLebanon B-LOC\non O\nSunday O\nto O\ndiscuss O\nan O\nIsraeli B-MISC\ncomplaint O\nagainst O\nthe O\nIslamic B-MISC\ngroup O\n, O\nthe O\nIsraeli B-MISC\narmy O\nsaid O\n. O\n\nRepresentatives O\nof O\nthe O\nfive O\nnations O\nmaking O\nup O\nthe O\ncommittee O\n-- O\nIsrael B-LOC\n, O\nLebanon B-LOC\n, O\nSyria B-LOC\n, O\nFrance B-LOC\nand O\nthe O\nUnited B-LOC\nStates I-LOC\n-- O\nwill O\nmeet O\nat O\n11 O\na.m. O\n( O\n0800 O\nGMT B-MISC\n) O\nin O\nNaqoura B-LOC\n, O\nthe O\ncoastal O\nheadquarters O\nof O\nthe O\nU.N. B-ORG\nInterim I-ORG\nForce I-ORG\nin I-ORG\nLebanon I-ORG\n( O\nUNIFIL B-ORG\n) O\n. O\n\n\" O\nThe O\ncommittee O\nwill O\nmeet O\nfollowing O\na O\ncomplaint O\nby O\nIsrael B-LOC\nover O\nan O\nincident O\nin O\nwhich O\ntwo O\nLebanese B-MISC\nresidents O\nwere O\ninjured O\nby O\nHizbollah B-ORG\nfire O\nin O\nthe O\nSikhin B-LOC\nvillage O\n... O\n\non O\nAugust O\n29 O\n, O\n\" O\nan O\nIsraeli B-MISC\narmy O\nspokeswoman O\nsaid O\non O\nSaturday O\n. O\n\nThe O\nmonitoring O\ncommittee O\nwas O\nset O\nup O\nto O\ndeal O\nwith O\nviolations O\nof O\nan O\nApril O\n25 O\nceasefire O\nunderstanding O\nthat O\nended O\n17 O\ndays O\nof O\nfighting O\nbetween O\nIsrael B-LOC\nand O\nthe O\nguerrillas O\n. O\n\nThe O\nunderstandings O\nforbid O\nfiring O\nfrom O\nor O\nat O\ncivilian O\ntargest O\nbut O\ndo O\nnot O\nrule O\nout O\nguerrilla O\nattacks O\non O\nIsraeli B-MISC\ntroops O\nand O\ntheir O\nlocal O\nmilitia O\nallies O\nin O\nsouth O\nLebanon B-LOC\n. O\n\nAround O\n1,000 O\nIsraeli B-MISC\ntroops O\npatrol O\na O\n15 O\nkm O\n( O\nnine-mile O\n) O\nsouth O\nLebanon B-LOC\noccupation O\nzone O\nwhich O\nthe O\nJewish B-MISC\nstate O\ncarved O\nout O\nin O\n1985 O\nto O\nprevent O\nattacks O\non O\nits O\nnorthern O\nbordder O\n. O\n\nHizbollah B-ORG\n( O\nParty B-ORG\nof I-ORG\nGod I-ORG\n) O\ngunmen O\nhave O\nwaged O\na O\nguerrilla O\nwar O\nto O\noust O\nIsrael B-LOC\nfrom O\nthe O\narea O\n. O\n\n-DOCSTART- O\n\nKPD B-ORG\nconfirms O\nIraqi B-MISC\nmilitary O\naid-U.N. B-MISC\nofficial O\n. O\n\nBAGHDAD B-LOC\n1996-08-31 O\n\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nKDP B-ORG\n) O\nof O\nMassoud B-PER\nBarzani I-PER\nsaid O\nthat O\nit O\nwas O\nbeing O\nbacked O\nby O\nIraqi B-MISC\nheavy O\narmour O\nand O\nartillery O\nin O\na O\nbattle O\nwith O\nrival O\nKurds B-MISC\nfor O\nthe O\ncity O\nof O\nArbil B-LOC\n, O\na O\nsenior O\nU.N. B-ORG\nofficial O\nin O\nBaghdad B-LOC\nsaid O\n. O\n\n\" O\nThey O\nhave O\nconfirmed O\nto O\nus O\nthat O\nIraqi B-MISC\ntroops O\nare O\ntaking O\npart O\nin O\nthe O\nattack O\non O\nArbil B-LOC\n... O\n\nWe O\ngot O\nthe O\ninformation O\nfrom O\nKDP B-ORG\nleaders O\nin O\nKDP B-ORG\nheadquarters O\nin O\nSaladdin B-LOC\n, O\n\" O\nthe O\nofficial O\n, O\nwho O\nasked O\nnot O\nto O\nbe O\nidentified O\n, O\ntold O\nReuters B-ORG\n. O\n\n-DOCSTART- O\n\nFire O\ndestroys O\nrestaurant O\nin O\nBahraini B-LOC\nvillage O\n. O\n\nMANAMA B-LOC\n1996-08-31 O\n\nA O\nfire O\nhas O\ncompletely O\ngutted O\na O\nTurkish-operated O\nrestaurant O\nin O\na O\nBahraini B-LOC\nvillage O\n, O\nresidents O\nsaid O\n. O\n\nThey O\nsaid O\na O\nfire O\nbroke O\nout O\nat O\nShul'ala B-LOC\nrestaurant O\nin O\nthe O\nearly O\nhours O\non O\nSaturday O\nin O\nal-Daih B-LOC\nvillage O\n, O\nfive O\nkm O\n( O\nthree O\nmiles O\n) O\nwest O\nof O\nthe O\ncapital O\nManama B-LOC\n. O\n\nIt O\nwas O\nnot O\nimmediately O\nclear O\nwhat O\ncaused O\nthe O\nfire O\nor O\nif O\nthere O\nwere O\nany O\ncasualties O\n. O\n\nGovernment O\nofficials O\nhad O\nno O\nimmediate O\ncomment O\n. O\n\n-DOCSTART- O\n\nIraq B-LOC\n's O\nAziz B-PER\nsays O\nBaghdad B-LOC\naiding O\nKDP B-ORG\nagainst O\nrivals O\n. O\n\nBAGHDAD B-LOC\n1996-08-31 O\n\nIraq B-LOC\n's O\nDeputy O\nPrime O\nMinister O\nTareq B-PER\nAziz I-PER\nsaid O\non O\nSaturday O\nIraqi B-MISC\ntroops O\nwere O\nfighting O\nin O\nnorthern O\nIraq B-LOC\nto O\naid O\nKurdish B-MISC\nrebel O\nleader O\nMassoud B-PER\nBarzani I-PER\nagainst O\nrival O\nforces O\n. O\n\n\" O\nThe O\nleadership O\nhas O\ndecided O\nto O\nprovide O\nsupport O\nand O\nmilitary O\naid O\nto O\nMr O\nMassoud B-PER\nBarzani I-PER\nand O\nhis O\ncomrades O\nto O\nenable O\nthem O\nconfront O\nthe O\nvicious O\naggression O\n... O\n\nfrom O\n( O\nPatriotic B-ORG\nUnion I-ORG\nof I-ORG\nKurdistan I-ORG\nchief O\n) O\nJalal B-PER\nTalabani I-PER\n, O\n\" O\nAziz B-PER\nsaid O\nin O\na O\nstatement O\ncarried O\nby O\nthe O\nofficial O\nIraqi B-ORG\nNews I-ORG\nAgency I-ORG\n( O\nINA B-ORG\n) O\n. O\n\nAziz B-PER\nsaid O\nIraq B-LOC\n's O\nmilitary O\nintervention O\n, O\nthe O\nfirst O\non O\nsuch O\nscale O\nsince O\nthe O\nU.S. B-LOC\nand O\nallies O\ndecided O\nto O\nprotect O\nIraqi B-MISC\nKurds I-MISC\nagainst O\nBaghdad B-LOC\n, O\nwas O\nin O\nresponse O\nto O\na O\nplea O\nfrom O\nBarzani B-PER\nto O\nPresident O\nSaddam B-PER\nHussein I-PER\nto O\nback O\nhim O\nmilitarily O\nand O\nsave O\nhis O\npeople O\nfrom O\nattacks O\nby O\nIran B-LOC\nand O\nTalabani B-PER\n. O\n\nHe O\nsaid O\nBarzani B-PER\nsent O\na O\nmessage O\nto O\nSaddam B-PER\non O\nAugust O\n22 O\nin O\nwhich O\nhe O\nsaid O\n: O\n\" O\nThe O\nconspiracy O\nis O\nbeyond O\nour O\ncapability O\ntherefore O\nwe O\nplead O\nwith O\nyour O\nexcellency O\nto O\norder O\nIraqi B-MISC\narmed O\nforces O\nto O\ninterfere O\nto O\nhelp O\nus O\nto O\nevade O\nthe O\nforeign O\nthreat O\nand O\nput O\nan O\nend O\nto O\nTalabani B-PER\n's O\ntreason O\nand O\nconspiracy O\n. O\n\" O\n\nU.N. B-ORG\nrelief O\nofficials O\nsaid O\nthey O\nwere O\nnot O\naware O\nthat O\nthe O\ntanks O\nadvancing O\non O\nArbil B-LOC\nwere O\nmanned O\nby O\nIraqi B-MISC\ntroops O\nas O\nthey O\nadvanced O\nfrom O\nKDP-controlled O\nareas O\nand O\nraised O\nKDP B-ORG\nflags O\n. O\n\n-DOCSTART- O\n\nU.N. B-ORG\ndenies O\nreports O\nof O\nIraqi B-MISC\ntank O\nassault O\non O\nArbil B-LOC\n. O\n\nBAGHDAD B-LOC\n1996-08-31 O\n\nUnited B-ORG\nNations I-ORG\nrelief O\nofficials O\nsaid O\non O\nSaturday O\nthe O\nfighting O\nin O\nArbil B-LOC\nin O\nnorthern O\nIraq B-LOC\nwas O\nbetween O\nrival O\nKurdish B-MISC\nfactions O\nand O\nthey O\nwere O\nnot O\naware O\nof O\nany O\nIraqi B-MISC\nmilitary O\nadvance O\non O\nthe O\ncity O\n. O\n\n\" O\nKDP B-ORG\n( O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n) O\nis O\ntrying O\nto O\novertake O\nthe O\ncity O\n. O\n\nThey O\nare O\nusing O\ntanks O\n. O\n\nI O\nthink O\nthey O\nwill O\nsucceed O\n. O\n\nWe O\nhave O\nin O\nno O\nway O\nseen O\nany O\nIraqi B-MISC\ntroops O\nin O\nthe O\ncity O\nor O\nin O\nits O\napproaches O\n, O\n\" O\na O\nU.N. B-ORG\nrelief O\nofficial O\ntold O\nReuters B-ORG\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nTunisia B-LOC\n- O\nAug O\n31 O\n. O\n\nTUNIS B-LOC\n1996-08-31 O\n\nThese O\nare O\nthe O\nleading O\nstories O\nin O\nthe O\nTunisian B-MISC\npress O\non O\nSaturday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nLA B-ORG\nPRESSE I-ORG\n\n- O\nAfter O\nTunisia B-LOC\ncalled O\non O\nFrance B-LOC\nto O\nrespect O\nTunisian B-MISC\nimmigrants O\n' O\ndignity O\n, O\nFrance B-LOC\nsays O\nit O\nwelcomes O\nlegal O\nTunisian B-MISC\nresidents O\n. O\n\n- O\nTunisia B-LOC\n's O\nexports O\nof O\nspare O\nparts O\namounted O\nto O\n220 O\nmillion O\ndinars O\nin O\n1995 O\n. O\n\nLE B-ORG\nTEMPS I-ORG\n\n- O\nTrade O\ntalks O\nbetween O\nTunisia B-LOC\nand O\nthe O\nPalestinian B-ORG\nAuthority I-ORG\n. O\n\n- O\nSpeaker O\nof O\nparliament O\nHabib B-PER\nBoulares I-PER\narrives O\nin O\nTripoli B-LOC\nto O\nrepresent O\nPresident O\nZine B-PER\nal-Abidine I-PER\nBen I-PER\nAli I-PER\nat O\nthe O\nLibyan B-MISC\nrevolution O\nanniversary O\ncelebrations O\n. O\n\n( O\n$ O\n1 O\n= O\n0.96 O\ndinar O\n) O\n\n-DOCSTART- O\n\nAutomakers O\n, O\nU.S. B-LOC\nagency O\nplan O\nair O\nbag O\nsafety O\nads O\n. O\n\nDETROIT B-LOC\n1996-08-31 O\n\nAutomakers O\n, O\nsuppliers O\n, O\ninsurers O\nand O\nthe O\nfederal O\ngovernment O\n's O\nauto O\nsafety O\nagency O\nSaturday O\nlaunched O\na O\n$ O\n10 O\nmillion O\nsafety O\nawareness O\ncampaign O\naimed O\nat O\nreducing O\nthe O\nnumber O\nof O\nchildren O\nkilled O\naccidentally O\nby O\nair O\nbags O\nin O\ncars O\nand O\ntrucks O\n. O\n\nOfficials O\nsaid O\nthey O\nwill O\nwork O\nwith O\nlaw O\nenforcement O\nagencies O\n, O\npediatricians O\nand O\nmedia O\nto O\nwarn O\nparents O\nabout O\nthe O\ndangers O\nthat O\nair O\nbags O\npose O\nto O\nchildren O\nand O\nadults O\nnot O\nwearing O\nseatbelts O\n. O\n\nSince O\n1993 O\n, O\n24 O\nchildren O\nhave O\nbeen O\nkilled O\nby O\nthe O\nexplosive O\nforce O\nof O\nautomotive O\nair O\nbags O\n, O\nwhich O\ninflate O\nat O\nspeeds O\nup O\nto O\n200 O\nmiles O\nper O\nhour O\n. O\n\nThe O\nfirst O\nportion O\nof O\nthe O\ncampaign O\ninvolves O\npickup O\ntrucks O\nequipped O\nwith O\nbillboards O\nthat O\nwere O\ndriving O\nalong O\nsome O\nof O\nthe O\nnation O\n's O\nbusiest O\ninterstate O\nhighways O\nduring O\nthe O\nLabor B-MISC\nDay I-MISC\nweekend O\n, O\nincluding O\nInterstate B-LOC\n95 I-LOC\non O\nthe O\nEast B-LOC\nCoast I-LOC\n, O\nInterstates B-LOC\n80 I-LOC\nand O\n90 B-LOC\nin O\nthe O\nMidwest B-LOC\nand O\nInterstate B-LOC\n5 I-LOC\nin O\nCalifornia B-LOC\n. O\n\nThe O\nboards O\nread O\n: O\n\" O\nAir O\nBag O\nSafety O\n: O\nEveryone O\nBuckled O\n, O\nKids O\nin O\nBack O\n. O\n\" O\n\nJanet B-PER\nDewey I-PER\n, O\nexecutive O\ndirector O\nof O\nthe O\nindustry-funded O\nNational B-ORG\nAutomobile I-ORG\nOccupant I-ORG\nProtection I-ORG\nCampaign I-ORG\n, O\nsaid O\nmost O\nof O\nthe O\ninjuries O\nto O\nchildren O\noccurred O\nbecause O\nthey O\nwere O\nnot O\nwearing O\nseatbelts O\n. O\n\nA O\nchild O\n's O\nchances O\nof O\nbeing O\nkilled O\nin O\na O\ncar O\naccident O\n, O\nwhether O\nthe O\nvehicle O\nwas O\nequipped O\nwith O\nan O\nair O\nbag O\nor O\nnot O\n, O\nis O\nreduced O\nby O\n29 O\npercent O\nwhen O\nthey O\nare O\nin O\nthe O\nrear O\nseat O\n, O\nshe O\nsaid O\n. O\n\nThe O\nauto O\nindustry O\nwas O\nabout O\nthree O\nto O\nsix O\nyears O\naway O\nfrom O\nintroducing O\n\" O\nsmart O\n\" O\nair O\nbags O\nwith O\nthe O\nability O\nto O\ndetect O\nthe O\nsize O\nand O\nposition O\nof O\nan O\noccupant O\nand O\nadjust O\ninflation O\npressures O\naccordingly O\n. O\n\nCurrent O\nair O\nbags O\nwere O\ndesigned O\nto O\nhalt O\nthe O\nforward O\nmomentum O\nof O\nan O\naverage-sized O\n, O\nunbelted O\nadult O\nmale O\n, O\nnot O\na O\nsmall O\nchild O\n. O\n\nAutomakers O\npetitioned O\nthe O\nNational B-ORG\nHighway I-ORG\nTraffic I-ORG\nSafety I-ORG\nAdministration I-ORG\nto O\nallow O\nthem O\nto O\nintroduce O\nair O\nbags O\nthat O\ninflate O\nless O\naggressively O\nto O\nhelp O\nreduce O\nunwanted O\ninjuries O\n. O\n\n\" O\nEven O\nif O\nchanges O\nare O\nmade O\nto O\nairbags O\ntoday O\n, O\nwe O\n'd O\nstill O\nhave O\n20 O\nmillion O\nvehicles O\non O\nthe O\nroad O\nwith O\ncurrent O\ntechnology O\n, O\n\" O\nDewey B-PER\nsaid O\n. O\n\" O\n\nThe O\npublic O\nhas O\nn't O\nbeen O\ngetting O\nthe O\nmessage O\n. O\n\" O\n\n-DOCSTART- O\n\nTwo O\ndie O\nas O\nNew B-LOC\nHampshire I-LOC\nmotel O\nexplodes O\nand O\nburns O\n. O\n\nROCHESTER B-LOC\n, O\nN.H. B-LOC\n1996-08-30 O\n\nAdds O\ndeaths O\n, O\nother O\ndetails O\n) O\n\nAn O\nexplosion O\nleveled O\nRochester B-LOC\n's O\none-story O\nLilac B-LOC\nFalls I-LOC\nMotel O\n, O\nkilling O\ntwo O\npeople O\n, O\nfire O\nofficials O\nsaid O\nFriday O\n. O\n\n\" O\nIt O\nwas O\nan O\nexplosion O\n, O\nand O\nthen O\nit O\ngot O\ninvolved O\nin O\nfire O\n. O\n\nAs O\nfar O\nas O\nI O\nknow O\n, O\nit O\n's O\nbeen O\nto O\nfour O\nalarms O\n-- O\nmore O\ntrucks O\n, O\nmore O\npeople O\n, O\n\" O\nsaid O\nDon B-PER\nPenney I-PER\nof O\nthe O\nRochester B-ORG\nFire I-ORG\nDepartment I-ORG\nsaid O\n. O\n\nEyewitnesses O\ntold O\nBoston B-LOC\ntelevision O\nstations O\nthey O\nsaw O\na O\ngasoline O\ntruck O\nparked O\nbehind O\nthe O\nLilac B-LOC\nFalls I-LOC\nMotel I-LOC\nand O\nsmelled O\ngasoline O\nshortly O\nbefore O\nthe O\nexplosion O\n. O\n\nFire O\ndepartment O\nofficials O\nsaid O\nthey O\nwere O\ninvestigating O\nthe O\ncause O\nof O\nthe O\nblast O\nand O\nsearching O\nfor O\nany O\nmore O\ncasualties O\n. O\n\nOfficials O\ndid O\nnot O\nimmediately O\nidentify O\nthe O\nvictims O\n. O\n\nLocal O\nhospital O\nofficials O\nsaid O\na O\nfew O\nfiremen O\nwere O\ntreated O\nfor O\nsmoke O\ninhalation O\nbut O\nthere O\nwere O\nno O\nother O\ninjuries O\n. O\n\n-DOCSTART- O\n\nCar O\nkills O\ntwo O\ntrying O\nto O\navoid O\nTexas B-LOC\ndrag O\nrace O\n. O\n\nDALLAS B-LOC\n1996-08-31 O\n\nAn O\nillegal O\ndrag O\nrace O\non O\na O\nDallas B-LOC\nstreet O\nturned O\ndeadly O\nwhen O\nanother O\nvehicle O\nveered O\ninto O\nthe O\ncrowd O\n, O\nkilling O\ntwo O\npeople O\nand O\ninjuring O\na O\ndozen O\nmore O\n, O\npolice O\nsaid O\nSaturday O\n. O\n\nOrganisers O\ntried O\nto O\nblock O\noff O\ntraffic O\nwhile O\npreparing O\nthe O\ndrag O\nrace O\nlate O\non O\nFriday O\n, O\nbut O\nan O\nallegedly O\ndrunk O\ndriver O\nwas O\nunable O\nto O\nslow O\ndown O\nin O\ntime O\nand O\nran O\ninto O\na O\ngroup O\nof O\nspectators O\nas O\nhe O\nswerved O\nto O\navoid O\none O\nof O\nthe O\ncars O\nthat O\nwas O\nto O\ntake O\npart O\nin O\nthe O\nrace O\n. O\n\nA O\n26-year-old O\nman O\nand O\nan O\n18-year-old O\nwoman O\nwere O\nkilled O\n. O\n\nThe O\ndriver O\n, O\naged O\n51 O\n, O\nwas O\narrested O\nand O\ncharged O\non O\ntwo O\ncounts O\nof O\nintoxicated O\nmanslaughter O\n. O\n\nA O\npolice O\nspokesman O\nsaid O\nthe O\nstraight O\n, O\nflat O\nstretch O\nof O\nroad O\nwas O\noften O\nused O\nillegally O\nas O\na O\ndrag O\nstrip O\nby O\nDallas B-LOC\nyouths O\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nwarplanes O\n, O\nships O\nin O\nGulf B-LOC\nawait O\nClinton B-PER\norder O\n. O\n\nJim B-PER\nAdams I-PER\n\nWASHINGTON B-LOC\n1996-08-31 O\n\nMore O\nthan O\n300 O\nU.S. B-LOC\nwarplanes O\nand O\n20 O\nships O\nwere O\navailable O\non O\nSaturday O\nin O\ncase O\nPresident O\nBill B-PER\nClinton I-PER\nordered O\nthe O\nuse O\nof O\nU.S. B-LOC\nforce O\nagainst O\nIraqi B-MISC\nmilitary O\naction O\nin O\nnorthern O\nIraq B-LOC\n, O\nU.S. B-LOC\ndefense O\nofficials O\nsaid O\n. O\n\nThey O\nsaid O\n200 O\nfighter O\nplanes O\n, O\nincluding O\n79 O\non O\nthe O\naircraft O\ncarrier O\nCarl B-MISC\nVinson I-MISC\n, O\nwere O\nalready O\nin O\nthe O\nGulf B-LOC\n; O\nthe O\naircraft O\ncarrier O\nEnterprise B-MISC\nwas O\nin O\nthe O\neastern O\nMediterranean B-MISC\nwith O\n79 O\nmore O\n, O\nand O\nan O\nair O\nexpeditionary O\nforce O\nwith O\nup O\nto O\n40 O\nmore O\nwas O\nready O\nto O\nfly O\nfrom O\nthe O\nUnited B-LOC\nStates I-LOC\nif O\nordered O\n. O\n\n\" O\nYesterday O\nthe O\npresident O\nordered O\nthe O\nDepartment B-ORG\nof I-ORG\nDefense I-ORG\nto O\ntake O\nprudent O\nplanning O\nsteps O\nto O\nhave O\nforces O\nready O\nto O\ndeploy O\nto O\nthe O\nregion O\nshould O\nhe O\ndirect O\nus O\nto O\ndo O\nso O\n, O\n\" O\nPentagon B-ORG\nspokesman O\nDoug B-PER\nKennett I-PER\nsaid O\n. O\n\" O\n\nWe O\nhave O\ntaken O\nthose O\nprudent O\nplanning O\nsteps O\n. O\n\" O\n\nClinton B-PER\nsaid O\non O\nSaturday O\nhe O\nhad O\nordered O\nU.S. B-LOC\nforces O\nin O\nthe O\nGulf B-LOC\nto O\ngo O\non O\nhigh O\nalert O\nand O\nwas O\nreinforcing O\nthem O\nin O\nresponse O\nto O\nIraqi B-MISC\nattacks O\non O\nKurdish B-MISC\ndissidents O\nin O\nnorthern O\nIraq B-LOC\n. O\n\n\" O\nThese O\ndevelopments O\n... O\ncause O\nme O\ngrave O\nconcern O\n, O\n\" O\nClinton B-PER\nsaid O\nat O\na O\ncampaign O\nstop O\nin O\nTroy B-LOC\n, O\nTennessee B-LOC\n. O\n\nBut O\nhe O\nadded O\n, O\n\" O\nIt O\nis O\npremature O\nat O\nthis O\ntime O\n, O\nand O\nI O\nwant O\nto O\nemphasize O\nthat O\n, O\nhighly O\npremature O\nto O\nspeculate O\non O\nany O\nresponse O\nwe O\nmight O\nhave O\n. O\n\" O\n\nThe O\nU.S. B-LOC\ndefense O\nofficials O\nsaid O\nmilitary O\nflights O\nto O\nenforce O\nno-fly O\nzones O\nin O\nboth O\nnorthern O\nand O\nsouthern O\nIraq B-LOC\ndoubled O\nover O\nthe O\nweekend O\n. O\n\nClinton B-PER\nsaid O\nIraqi B-MISC\nmilitary O\nforces O\noverran O\nthe O\ncity O\nof O\nArbil B-LOC\n, O\nwhich O\nhas O\nbeen O\nheld O\nsince O\n1994 O\nby O\nKurdish B-MISC\nrebels O\nwho O\nBaghdad B-LOC\nsays O\nare O\nbacked O\nby O\nIran B-LOC\n. O\n\nThere O\nwere O\nunconfirmed O\nreports O\nthat O\nIran B-LOC\nhad O\nsent O\ntroops O\ninto O\nnorthern O\nIraq B-LOC\nin O\nresponse O\nto O\nIraq B-LOC\n's O\nattack O\n. O\n\nU.S. B-LOC\nplans O\nrely O\nheavily O\non O\nU.S. B-LOC\nair O\nattacks O\non O\nIraqi B-MISC\nforces O\n, O\nbut O\nthere O\nare O\nalso O\n23,000 O\nU.S. B-LOC\ntroops O\nin O\nthe O\nregion O\n, O\naccording O\nto O\ndefense O\nofficials O\n. O\n\nIn O\naddition O\nto O\nthe O\n158 O\nF B-MISC\n/ I-MISC\nA-18 I-MISC\n, O\nF-14 B-MISC\nand O\nother O\nfighter O\nplanes O\non O\nthe O\naircraft O\ncarriers O\nVinson B-MISC\nand O\nEnterprise B-MISC\n, O\nthe O\nAir B-ORG\nForce I-ORG\nair O\nexpeditionary O\nforce O\nof O\n30 O\nto O\n40 O\nF-15 B-MISC\nand O\nF-16 B-MISC\nfighter O\nplanes O\nand O\nfuel O\ntankers O\nis O\nready O\nto O\nfly O\nfrom O\nthree O\nU.S. B-LOC\nbases O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\n, O\nthey O\nsaid O\n. O\n\nThe O\nexpeditionary O\nforce O\nwould O\ninclude O\nnearly O\n1,000 O\nAir B-ORG\nForce I-ORG\npersonnel O\nin O\nground O\nand O\nsupport O\ncrews O\n, O\nthey O\nsaid O\n. O\n\nThe O\n23,000 O\nU.S. B-LOC\nmilitary O\npeople O\nalready O\nin O\nthe O\nGulf B-LOC\nconsist O\nof O\n15,000 O\nsailors O\nand O\nMarines B-MISC\n, O\n6,000 O\nU.S. B-LOC\nservicemen O\nbased O\nprimarily O\nin O\nSaudi B-LOC\nArabia I-LOC\nand O\n2,000 O\nU.S. B-LOC\ntroops O\nin O\nthe O\narea O\nfor O\nmilitary O\nexercises O\n. O\n\nMost O\nof O\nthe O\nMarines B-MISC\nare O\non O\nthree O\nships O\nin O\nthe O\nTarawa B-ORG\nAmphibious I-ORG\nReadiness I-ORG\nGroup I-ORG\n. O\n\nThe O\nCarl B-MISC\nVinson I-MISC\nleads O\na O\nbattle O\ngroup O\nthat O\nincludes O\nseven O\nother O\nships O\n, O\nand O\nthere O\nare O\nnine O\nother O\nU.S. B-LOC\nships O\nin O\nthe O\nGulf B-LOC\nfor O\na O\ntotal O\nof O\n20 O\n. O\n\n-DOCSTART- O\n\nTwo O\nmissing O\nBelgian B-MISC\nteenagers O\nfound O\nunharmed O\n. O\n\nBRUSSELS B-LOC\n1996-08-31 O\n\nTwo O\nBelgian B-MISC\nteenage O\ngirls O\nmissing O\nsince O\nThursday O\nhave O\nbeen O\nfound O\nunharmed O\n, O\npolice O\nsaid O\non O\nSaturday O\n. O\n\n\" O\nThe O\ngirls O\n, O\nRachel B-PER\nand O\nSeverine B-PER\n, O\nhave O\nbeen O\nfound O\n. O\n\nThey O\nare O\nunharmed O\n, O\n\" O\na O\npolice O\nofficial O\nin O\nLiege B-LOC\nsaid O\n. O\n\nHe O\ndeclined O\nto O\nsay O\nwhether O\nthe O\ngirls O\nhad O\nbeen O\nkidnapped O\nor O\nwhether O\nthey O\nhad O\ngone O\naway O\nof O\ntheir O\nown O\naccord O\n. O\n\nLate O\non O\nFriday O\n, O\nthe O\ntwo O\ngirls O\n-- O\nRachel B-PER\nLegeard I-PER\n, O\n18 O\n, O\nand O\nSeverine B-PER\nPotty I-PER\n, O\n19 O\n-- O\nwere O\nreported O\nmissing O\nafter O\nfailing O\nto O\nreturn O\nhome O\nfrom O\na O\nshopping O\ntrip O\nto O\nthe O\neastern O\ntown O\nof O\nLiege B-LOC\non O\nThursday O\n. O\n\nEarlier O\n, O\npolice O\ndeclined O\nto O\ncomment O\non O\nwhether O\nit O\nsuspected O\na O\nlink O\nwith O\nthe O\nMarc B-PER\nDutroux I-PER\ncase O\n, O\nthe O\npaedophile O\nkidnap O\n, O\nsex O\nabuse O\nand O\nmurder O\nscandal O\nwhich O\nhas O\nrocked O\nBelgium B-LOC\nin O\nthe O\npast O\ntwo O\nweeks O\n. O\n\n-DOCSTART- O\n\nAlgeria B-LOC\nrestaurant O\nbomb O\nkills O\nseven O\n- O\nnewSpaper O\n. O\n\nPARIS B-LOC\n1996-08-31 O\n\nA O\nbomb O\nexplosion O\nin O\na O\nrestaurant O\nwest O\nof O\nAlgiers B-LOC\non O\nFriday O\nkilled O\nseven O\npeople O\n, O\nan O\nAlgerian B-MISC\nnewspaper O\nsaid O\non O\nSaturday O\n. O\n\nAlgerian B-MISC\nsecurity O\nforces O\nsaid O\nin O\na O\nstatement O\nthat O\ntwo O\npeople O\nwere O\nkilled O\nand O\nsix O\nwere O\nwounded O\nwhen O\na O\nhome-made O\nbomb O\nripped O\nthrough O\na O\nrestaurant O\nin O\nthe O\ncoastal O\ntown O\nof O\nStaoueli B-LOC\n. O\n\nBut O\nLe B-ORG\nMatin I-ORG\nnewspaper O\n, O\nquoting O\nwitnesses O\n, O\nsaid O\nthe O\nbomb O\nkilled O\nseven O\npeople O\nand O\nwounded O\n20 O\n. O\n\nLiberte B-ORG\nnewspaper O\nsaid O\nthe O\nbomb O\nwas O\nhidden O\nin O\na O\nbag O\nin O\nfront O\nof O\nthe O\nrestaurant O\nand O\nthat O\na O\nbooby-trapped O\ncar O\nwas O\ndefused O\nnear O\nthe O\nrestaurant O\nshortly O\nbefore O\nthe O\nbomb O\nwent O\noff O\n. O\n\nA O\nweek O\nago O\na O\nhome-made O\nbomb O\nexploded O\nin O\na O\nmarket O\nin O\nthe O\nwestern O\ncoastal O\ntown O\nof O\nBou B-LOC\nHaroun I-LOC\n, O\n65 O\nkm O\n( O\n40 O\nmiles O\n) O\nfrom O\nAlgiers B-LOC\n. O\n\nNewspapers O\nsaid O\nit O\nkilled O\ntwo O\nwomen O\nand O\nfive O\nchildren O\n. O\n\nAlgerian B-MISC\nnewspapers O\nquoted O\nthe O\nHuman B-ORG\nRights I-ORG\nNational I-ORG\nObservatory I-ORG\n( O\nONDH B-ORG\n) O\n, O\na O\ngovernment-appointed O\nwatchdog O\n, O\nas O\nsaying O\nearlier O\nin O\nAugust O\nthat O\nabout O\n1,400 O\ncivilians O\nhad O\nbeen O\nkilled O\nin O\nbomb O\nattacks O\nblamed O\non O\nMoslem B-MISC\nguerrillas O\nin O\nthe O\npast O\ntwo O\nyears O\n. O\n\nAn O\nestimated O\n50,000 O\npeople O\nhave O\ndied O\nin O\nAlgeria B-LOC\n's O\nviolence O\npitting O\nMoslem B-MISC\nrebels O\nagainst O\ngovernment O\nforces O\nsince O\nearly O\n1992 O\nwhen O\nthe O\nauthorities O\ncancelled O\na O\ngeneral O\nelection O\nin O\nwhich O\nradical O\nIslamists B-MISC\nhad O\ntaken O\na O\ncommanding O\nlead O\n. O\n\n-DOCSTART- O\n\nIran B-LOC\nagents O\nstormed O\nGerman B-MISC\ndiplomat O\n's O\nhome O\n-- O\nBonn B-LOC\n. O\n\nBONN B-LOC\n1996-08-31 O\n\nIranian B-MISC\nsecurity O\nforces O\nburst O\ninto O\nthe O\nhome O\nof O\na O\nGerman B-MISC\ncultural O\nattache O\nin O\nTehran B-LOC\na O\nmonth O\nago O\nand O\nseized O\nhis O\nguests O\nfor O\nquestioning O\n, O\nBonn B-LOC\n's O\nforeign O\nministry O\nsaid O\non O\nSaturday O\n. O\n\nA O\nspokesman O\nsaid O\nhe O\ncould O\nsubstantially O\nconfirm O\na O\nreport O\nin O\nthe O\nnews O\nweekly O\nDer B-ORG\nSpiegel I-ORG\n, O\nwhich O\nsaid O\nIranian B-MISC\nsecret O\npolice O\nburst O\nin O\nwhile O\nattache O\nJens B-PER\nGust I-PER\nwas O\nentertaining O\nsix O\nIranian B-MISC\nwriters O\nand O\ntheir O\nwives O\n. O\n\nGust B-PER\nwas O\nthreatened O\nwith O\nviolence O\n, O\nthen O\nlocked O\ninto O\na O\nroom O\nto O\nbe O\ninterrogated O\non O\nsuspicion O\nof O\n\" O\npromoting O\nactivities O\nhostile O\nto O\nthe O\nstate O\n\" O\nwhile O\nhis O\nguests O\nwere O\ntaken O\naway O\n, O\nthe O\nmagazine O\nsaid O\n. O\n\nThe O\nministry O\nspokesman O\nsaid O\nthe O\nGerman B-MISC\nembassy O\nimmediately O\nmade O\na O\nsharp O\nprotest O\nto O\nthe O\nTehran B-LOC\ngovernment O\n. O\n\nThe O\nIranian B-MISC\nambassador O\nwas O\nalso O\nsummoned O\nto O\nthe O\nministry O\nin O\nBonn B-LOC\nto O\nhear O\na O\nsharp O\nprotest O\nand O\n\" O\ndisapproval O\nof O\nthis O\nglaring O\nbreach O\nof O\nthe O\nprinciples O\nof O\ninternational O\nlaw O\n\" O\n, O\nhe O\nadded O\n. O\n\nIran B-LOC\nsubsequently O\nsaid O\nit O\nregretted O\nthe O\nincident O\n, O\nwhich O\nit O\nsaid O\nhad O\nbeen O\nthe O\nresult O\nof O\na O\nmisunderstanding O\n. O\n\nAll O\nthose O\ndetained O\nappeared O\nto O\nhave O\nbeen O\nfreed O\n, O\nthe O\nspokesman O\nsaid O\n. O\n\nRelations O\nbetween O\nthe O\ntwo O\ncountries O\nare O\ncurrently O\nunder O\nstrain O\nbecause O\nof O\nthe O\ntestimony O\nin O\na O\nBerlin B-LOC\ncourt O\nof O\nformer O\nIranian B-MISC\npresident O\nAbolhassan B-PER\nBanisadr I-PER\n. O\n\nBanisadr B-PER\n, O\nan O\navowed O\nopponent O\nof O\nthe O\nTehran B-LOC\ngovernment O\nwho O\nnow O\nlives O\nin O\nexile O\n, O\naccused O\ntop O\nIranian B-MISC\nleaders O\nof O\npersonally O\nordering O\nthe O\nassassination O\nof O\nthree O\nexiled O\nKurdish B-MISC\nleaders O\nin O\na O\nBerlin B-LOC\nrestaurant O\nin O\n1992 O\n. O\n\nIran B-LOC\nhas O\nasked O\nGermany B-LOC\nto O\nextradite O\nBanisadr B-PER\n, O\nwho O\nis O\ndue O\nis O\ndue O\nback O\nin O\nBerlin B-LOC\nnext O\nThursday O\nto O\ncontinue O\nhis O\ntestimony O\n. O\n\nBanisadr B-PER\n, O\nwho O\nreceived O\npolitical O\nasylum O\nin O\nFrance B-LOC\nafter O\nfleeing O\nthere O\nin O\n1981 O\n, O\ntold O\nDer B-ORG\nSpiegel I-ORG\nhe O\ndid O\nnot O\nplan O\nto O\nask O\nfor O\na O\nguarantee O\nof O\nsafe O\nconduct O\n. O\n\nIf O\nGermany B-LOC\nwere O\nto O\nextradite O\nhim O\n, O\nhe O\nsaid O\n, O\nit O\nwould O\n\" O\nlose O\nface O\nbefore O\nthe O\nwhole O\nworld O\n\" O\n. O\n\nGerman B-MISC\nprosecutors O\nhave O\nalready O\naccused O\nIran B-LOC\n's O\nintelligence O\nminister O\nAli B-PER\nFallahiyan I-PER\nof O\nordering O\nthe O\nkilling O\nof O\nthe O\nKurdish B-MISC\nleaders O\n. O\n\nIran B-LOC\n, O\nwhich O\ndenies O\nthe O\nallegations O\n, O\nurged O\nGerman B-MISC\nauthorities O\nto O\ndisregard O\nBanisadr B-PER\n's O\ntestimony O\nand O\nsaid O\nit O\ncould O\nhurt O\nrelations O\n. O\n\n-DOCSTART- O\n\nItaly B-LOC\n's O\nDini B-PER\nmeets O\nBurundi B-LOC\nnegotiator O\nNyerere B-PER\n. O\n\nROME B-LOC\n1996-08-31 O\n\nItalian B-MISC\nForeign O\nMinister O\nLamberto B-PER\nDini I-PER\non O\nSaturday O\nmet O\nformer O\nTanzanian B-MISC\npresident O\nJulius B-PER\nNyerere I-PER\n, O\nthe O\ninternational O\nnegotiator O\nfor O\nBurundi B-LOC\n, O\nthe O\nministry O\nsaid O\n. O\n\nNyerere B-PER\narrived O\nin O\nRome B-LOC\nthis O\nweek O\non O\na O\nprivate O\nvisit O\nand O\nheld O\ntalks O\nwith O\nthe O\nU.S. B-LOC\nspecial O\nenvoy O\nto O\nBurundi B-LOC\n, O\nHoward B-PER\nWolpe I-PER\n, O\nand O\nthe O\nSant B-ORG\n' I-ORG\nEgidio I-ORG\nCommunity I-ORG\n, O\nan O\nItalian B-MISC\nRoman B-MISC\nCatholic I-MISC\norganisation O\nwhich O\nhas O\nbeen O\nmonitoring O\nBurundi B-LOC\nclosely O\n. O\n\n\" O\n( O\nNyerere B-PER\n) O\ninformed O\nMinister O\nDini B-PER\nof O\nthe O\nlatest O\ndevelopments O\nin O\nthe O\n( O\nGreat B-LOC\nLakes I-LOC\n) O\nregion O\n, O\nwith O\nparticular O\nrespect O\nto O\nBurundi B-LOC\nfollowing O\nthe O\nmilitary O\ncoup O\nd'etat O\non O\nJuly O\n25 O\n, O\n\" O\nthe O\nministry O\nsaid O\nin O\na O\nstatement O\n. O\n\nIt O\ngave O\nno O\ndetails O\nof O\ntheir O\ntalks O\n. O\n\nNyerere B-PER\nwas O\ndue O\nto O\nbe O\npresented O\nwith O\nan O\n\" O\nArtisans B-MISC\nfor I-MISC\nPeace I-MISC\n\" O\nprize O\nby O\nthe O\nLay B-ORG\nVolunteers I-ORG\n' I-ORG\nInternational I-ORG\nOrganisation I-ORG\non O\nSunday O\n. O\n\nHe O\nleaves O\nRome B-LOC\non O\nMonday O\n. O\n\nThe O\nU.N. B-ORG\nSecurity I-ORG\nCouncil I-ORG\non O\nFriday O\ncondemned O\nthe O\ncoup O\nby O\nretired O\nTutsi B-MISC\nmajor O\nPierre B-PER\nBuyoya I-PER\nand O\nfor O\nthe O\nfirst O\ntime O\nsaid O\nin O\na O\nresolution O\nit O\nintended O\nto O\npressure O\nBuyoya B-PER\ninto O\nunconditional O\nnegotiations O\nwith O\nall O\nparties O\nand O\nfactions O\n\" O\nwithout O\nexception O\n\" O\n. O\n\nBuyoya B-PER\non O\nSaturday O\ndismissed O\nits O\nthreat O\nof O\nan O\narms O\nembargo O\nagainst O\nBurundi B-LOC\nand O\nflatly O\nruled O\nout O\ntalks O\nwith O\nHutu B-MISC\nrebels O\n. O\n\nSome O\n150,000 O\npeople O\n-- O\nmostly O\ncivilians O\n-- O\nhave O\ndied O\nin O\nBurundi B-LOC\nsince O\n1993 O\nwhen O\nthe O\ncountry O\n's O\nfirst O\ndemocratically O\nelected O\nHutu B-MISC\npresident O\nwas O\nkilled O\nin O\nan O\nattempted O\narmy O\ncoup O\n. O\n\n-DOCSTART- O\n\nNato O\ndeclines O\ncomment O\non O\nfighting O\nin O\nIraq B-LOC\n. O\n\nBRUSSELS B-LOC\n1996-08-31 O\n\nThe O\nNorth B-ORG\nAtlantic I-ORG\nTreaty I-ORG\nOrganisation I-ORG\n's O\nspokesman O\non O\nSaturday O\ndeclined O\nall O\ncomment O\non O\nreports O\nof O\narmed O\nconflict O\nin O\nnorthern O\nIraq B-LOC\n. O\n\nBut O\na O\nNATO B-ORG\nofficial O\ntold O\nReuters B-ORG\n: O\n\" O\nWe O\nare O\nwatching O\nthe O\nsituation O\nclosely O\n. O\n\" O\n\nEarlier O\non O\nSaturday O\n, O\nan O\nIraqi B-MISC\nKurd I-MISC\nleader O\nsaid O\nboth O\nIraqi B-MISC\ntroops O\nand O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nKDP B-ORG\n) O\nforces O\nwere O\nattacking O\nthe O\ncity O\nof O\nArbil B-LOC\nin O\nnorthern O\nIraq B-LOC\n. O\n\n-DOCSTART- O\n\nMore O\nautomatic O\nweapons O\nstolen O\nin O\nBelgium B-LOC\n. O\n\nBRUSSELS B-LOC\n1996-08-31 O\n\nMore O\nthan O\n10 O\nweapons O\n, O\nincluding O\nautomatic O\nKalashnikov B-MISC\nrifles O\n, O\nwere O\nstolen O\nfrom O\nan O\narms O\nstore O\nin O\nBelgium B-LOC\n, O\npolice O\nsaid O\non O\nSaturday O\n. O\n\nA O\npoliceman O\nin O\nthe O\nsouthern O\nBelgian B-MISC\ntown O\nof O\nChatelet B-LOC\ntold O\nReuters B-ORG\nthat O\nthieves O\nused O\na O\ncar O\nto O\nram O\nthe O\nwindow O\nof O\nan O\narms O\nstore O\nin O\nneighbouring O\nChatelineaux B-LOC\nlast O\nnight O\n. O\n\nIt O\nwas O\nthe O\nsecond O\narms O\nrobbery O\nthis O\nweek O\n. O\n\nOn O\nTuesday O\n, O\nthieves O\nstole O\nabout O\n40 O\nforearms O\nfrom O\na O\nshooting O\nrange O\nin O\nsouthern O\nBelgium B-LOC\n, O\nincluding O\nKalashnikov B-MISC\n, O\nUzi B-MISC\nand O\nFal B-MISC\nautomatic O\nweapons O\n. O\n\n-DOCSTART- O\n\nNo O\ntrace O\nof O\ntwo O\nmissing O\nteenagers O\nin O\nBelgium B-LOC\n. O\n\nBRUSSELS B-LOC\n1996-08-31 O\n\nBelgian B-MISC\npolice O\nsaid O\non O\nSaturday O\nthey O\nhad O\nfound O\nno O\ntrace O\nof O\ntwo O\nteenage O\ngirls O\nreported O\nmissing O\nduring O\na O\nshopping O\ntrip O\nthree O\ndays O\nago O\n. O\n\n\" O\nThere O\nis O\nno O\ntrace O\nso O\nfar O\n, O\nthe O\nenquiry O\nis O\ncontinuing O\n, O\n\" O\na O\nLiege B-LOC\npolice O\nofficial O\ntold O\nReuters B-ORG\n. O\n\nLate O\non O\nFriday O\n, O\nLiege B-LOC\npolice O\nsaid O\nin O\na O\nstatement O\nthat O\non O\nThursday O\n, O\nRachel B-PER\nLegeard I-PER\n, O\n18 O\n, O\nand O\nSeverine B-PER\nPotty I-PER\n, O\n19 O\n, O\nhad O\ngone O\nshopping O\nto O\nthe O\neastern O\ntown O\nof O\nLiege B-LOC\non O\nThursday O\n, O\nwhere O\nLegeard B-PER\n's O\nwallet O\nhad O\nbeen O\nstolen O\n. O\n\nAfter O\nreporting O\nthe O\ntheft O\nto O\nthe O\npolice O\n, O\nthey O\ntook O\na O\nbus O\nhome O\nand O\nreportedly O\ngot O\noff O\nthe O\nbus O\nbefore O\narriving O\nin O\ntheir O\nhome O\nvillage O\nof O\nNandrin B-LOC\n. O\n\nThey O\nhave O\nnot O\nbeen O\nseen O\nsince O\n. O\n\nPolice O\ndeclined O\nto O\ncomment O\non O\nwhether O\nit O\nsuspected O\na O\nlink O\nwith O\nthe O\nMarc B-PER\nDutroux I-PER\ncase O\n, O\nthe O\npaedophile O\nkidnap O\n, O\nsex O\nabuse O\nand O\nmurder O\nscandal O\nwhich O\nhas O\nrocked O\nBelgium B-LOC\nin O\nthe O\npast O\ntwo O\nweeks O\n. O\n\n-DOCSTART- O\n\nControversial O\nIRA B-ORG\nfilm O\nscreened O\nat O\nVenice B-LOC\nfestival O\n. O\n\nVera B-PER\nHaller I-PER\n\nVENICE O\n, O\nItaly B-LOC\n1996-08-31 O\n\nDublin-born O\ndirector O\nNeil B-PER\nJordan I-PER\nsays O\nhe O\nnever O\nlost O\nmore O\nsleep O\nover O\na O\nfilm O\nthan O\nover O\n\" O\nMichael B-MISC\nCollins I-MISC\n\" O\n, O\nhis O\ncontroversial O\nepic O\nabout O\nthe O\nIRA B-ORG\nwhich O\nhas O\nits O\npremiere O\non O\nSaturday O\nat O\nthe O\nVenice B-MISC\nFilm I-MISC\nFestival I-MISC\n. O\n\nThe O\nfilm O\n, O\nstarring O\nLiam B-PER\nNeeson I-PER\nand O\nJulia B-PER\nRoberts I-PER\n, O\nrecounts O\nthe O\nlife O\nof O\nMichael B-PER\nCollins I-PER\n, O\nthe O\nIrish B-ORG\nRepublican I-ORG\nArmy I-ORG\n's O\nDirector O\nof O\nIntelligence O\nwho O\nfought O\nfor O\nIrish B-MISC\nindependence O\nfrom O\n1919 O\nto O\n1921 O\n. O\n\nAlthough O\nnot O\ndue O\nfor O\nrelease O\nin O\nBritain B-LOC\nuntil O\nearly O\nnext O\nyear O\n, O\nsome O\npoliticians O\nhave O\nalready O\nsaid O\nthey O\nfeared O\nit O\nwould O\nfan O\nsectarian O\ntensions O\nin O\nBritish-ruled B-MISC\nNorthern B-LOC\nIreland I-LOC\n. O\n\nJordan B-PER\ndefends O\nhis O\ndecision O\nto O\nmake O\nthe O\nfilm O\n, O\nwhose O\nscreenplay O\nhe O\nwrote O\nhimself O\nafter O\nyears O\nof O\nresearch O\n, O\nsaying O\nit O\nwas O\n\" O\nmore O\nabout O\nhistory O\nthan O\nany O\npolitical O\nstatement O\n\" O\n. O\n\n\" O\nThe O\nfilm O\nspares O\nneither O\nthe O\nIrish B-MISC\nnor O\nthe O\nBritish B-MISC\nin O\nits O\ndepiction O\nof O\nthe O\nsavagery O\nof O\nthe O\ntime O\n, O\n\" O\nJordan B-PER\nsaid O\nin O\na O\nstatement O\nreleased O\nby O\nWarner B-ORG\nBros I-ORG\n. O\n\" O\n\nHow O\noften O\nhas O\nindependence O\nbeen O\nachieved O\nwithout O\nbloodshed O\n? O\n\nVery O\nrarely O\n. O\n\" O\n\nJordan B-PER\n, O\nwhose O\n1992 O\nfilm O\n\" O\nThe B-MISC\nCrying I-MISC\nGame I-MISC\n\" O\nalso O\ncame O\nunder O\nfire O\nfor O\nwhat O\nwas O\nperceived O\nas O\na O\nsympathetic O\nportrayal O\nof O\nthe O\nIRA B-ORG\n, O\nsaid O\nCollins B-PER\nwas O\nmore O\nthan O\njust O\na O\nrevolutionary O\n. O\n\n\" O\nHe O\ndeveloped O\ntechniques O\nof O\nguerilla O\nwarfare O\nlater O\ncopied O\nby O\nindependence O\nmovements O\naround O\nthe O\nworld O\n, O\nfrom O\nMao B-PER\nTse-Tung I-PER\nin O\nChina B-LOC\nto O\nYitzak B-PER\nShamir I-PER\nin O\nIsrael B-LOC\n, O\n\" O\nJordan B-PER\nsaid O\n. O\n\n\" O\nCollins B-PER\nwould O\nnever O\nbe O\na O\nproponent O\nof O\ncontemporary O\nterrorism O\nas O\npractised O\ntoday O\n. O\n\nHe O\nwas O\na O\nsoldier O\nand O\na O\nstatesman O\nand O\n, O\nover O\ntime O\n, O\na O\nman O\nof O\npeace O\n. O\n\" O\n\nLeeson B-PER\n, O\nthe O\nNorthern B-MISC\nIreland-born I-MISC\nactor O\nwho O\nwas O\nnominated O\nfor O\nan O\nOscar B-PER\nfor O\nbest O\nactor O\nfor O\nhis O\nperformance O\nin O\n\" O\nSchindler B-MISC\n's I-MISC\nList I-MISC\n\" O\n, O\nplays O\nthe O\nlead O\nrole O\nin O\nJordan B-PER\n's O\nfilm O\n. O\n\nAidan B-PER\nQuinn I-PER\nportrays O\nHarry B-PER\nBoland I-PER\n, O\nCollins B-PER\n' O\nbest O\nfriend O\n, O\nand O\nrival O\nfor O\nthe O\nlove O\nof O\nKitty B-PER\nKiernan I-PER\n, O\nplayed O\nby O\nRoberts B-PER\n. O\n\nMuch O\nof O\nthe O\nfilm O\nwas O\nshot O\non O\nlocation O\nin O\nDublin B-LOC\nwith O\nJordan B-PER\nusing O\nthousands O\nof O\nits O\ncitizens O\nas O\nunpaid O\nextras O\n. O\n\nA O\nset O\n, O\nhowever O\n, O\nwas O\nused O\nfor O\nthe O\nfighting O\nscenes O\n. O\n\nNoting O\nthat O\ninformation O\nabout O\nCollins B-PER\nwas O\n\" O\nas O\nmysterious O\nas O\nthe O\nexistence O\nhe O\nmaintained O\n\" O\n, O\nJordan B-PER\nsaid O\nhe O\nmade O\nsome O\nhistorical O\nassumptions O\nin O\nthe O\nfilm O\n. O\n\n\" O\nI O\nhave O\nmade O\nchoices O\nabout O\ncertain O\nevents O\nbased O\non O\nmy O\nown O\nextensive O\nresearch O\ninto O\nhis O\nletters O\nand O\nreported O\nspeeches O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nI O\nwanted O\nto O\nmake O\nthis O\na O\nstory O\nas O\naccurate O\nas O\npossible O\nwithout O\nkilling O\nit O\ndramatically O\nand O\nI O\nthink O\nI O\nhave O\n. O\n\nIt O\nis O\na O\nvery O\ntrue O\nfilm O\n. O\n\" O\n\nOne O\nof O\nthe O\nassumptions O\nis O\nhis O\ninterpretation O\nof O\nthe O\nmurky O\ncircumstances O\nsurrounding O\nthe O\nshooting O\ndeath O\nof O\nCollins B-PER\n, O\nwho O\nhad O\nbroken O\nwith O\nhis O\ncomrades O\nwhen O\nhe O\nsought O\na O\nnegotiated O\nsettlement O\nwith O\nBritain B-LOC\n, O\nin O\nan O\nambush O\nin O\n1922 O\n. O\n\n\" O\nI O\nhave O\nnever O\nlost O\nmore O\nsleep O\nover O\nthe O\nmaking O\nof O\na O\nfilm O\nthan O\nI O\nhave O\nover O\n' O\nMichael B-MISC\nCollins I-MISC\n' O\n, O\nbut O\nI O\n'll O\nnever O\nmake O\na O\nmore O\nimportant O\none O\n, O\n\" O\nJordan B-PER\nsaid O\n. O\n\n\" O\nIn O\nthe O\nlife O\nof O\none O\nperson O\nyou O\ncan O\ntell O\nthe O\nevents O\nthat O\nformed O\nthe O\nnorth O\nand O\nsouth O\nof O\nIreland B-LOC\nas O\nthey O\nare O\ntoday O\n. O\n\" O\n\n-DOCSTART- O\n\nDhaka B-LOC\nstocks O\nseen O\nsteady O\nin O\nabsence O\nof O\nbig O\nplayers O\n. O\n\nDHAKA B-LOC\n1996-08-31 O\n\nShares O\non O\nthe O\nDhaka B-ORG\nStock I-ORG\nExchange I-ORG\n( O\nDSE B-ORG\n) O\nmay O\nremain O\nsteady O\nas O\nsmall O\ninvestors O\nare O\nexpected O\nto O\ntarget O\nmainly O\nblue O\nchips O\nwhile O\noverseas O\ninvestors O\nwill O\nprefer O\nto O\nkeep O\nto O\nthe O\nsidelines O\nwhen O\nthe O\nmarket O\nreopens O\nafter O\nMoslem B-MISC\nFriday O\nweekend O\n, O\nbrokers O\nsaid O\n. O\n\n\" O\nThe O\nmarket O\nis O\nexpected O\nto O\nremain O\nsteady O\n. O\n\nThere O\nwill O\nbe O\nboth O\nbuying O\nand O\nselling O\npressure O\n, O\n\" O\nsaid O\nbroker O\nShakil B-PER\nRizvi I-PER\n. O\n\nBroker O\nKhurshid B-PER\nAlam I-PER\nsaid O\n: O\n\" O\nThe O\nmarket O\nsentiment O\nwill O\nremain O\nstrong O\n. O\n\nBut O\nthe O\nprices O\nmay O\nmove O\nin O\na O\nclose O\nrange O\nfollowing O\na O\ncontinued O\nmarket O\nuptrend O\n. O\n\" O\n\nBrokers O\nsaid O\nblue O\nchips O\nlike O\nIDLC B-ORG\n, O\nBangladesh B-ORG\nLamps I-ORG\n, O\nChittagong B-ORG\nCement I-ORG\nand O\nAtlas B-ORG\nBangladesh I-ORG\nwere O\nexpected O\nto O\nrise O\n. O\n\nThey O\nsaid O\nthere O\nwas O\nstill O\ndemand O\nfor O\nblue O\nchips O\nin O\nengineering O\nsector O\ndespite O\ntheir O\npersistent O\nrise O\nover O\nthe O\npast O\nseveral O\nsessions O\n. O\n\nThe O\nDSE B-ORG\nall O\nshare O\nprice O\nindex O\nclosed O\n2.73 O\npoints O\nor O\n0.22 O\npercent O\nup O\nat O\n1,196.35 O\non O\na O\nturnover O\nof O\n133.7 O\nmillion O\ntaka O\non O\nThursday O\n. O\n\n-- O\nDhaka B-ORG\nNewsroom I-ORG\n880-2-506363 O\n\n"
  },
  {
    "path": "dataset/CONLL/test.txt",
    "content": "SOCCER O\n- O\nJAPAN B-LOC\nGET O\nLUCKY O\nWIN O\n, O\nCHINA B-PER\nIN O\nSURPRISE O\nDEFEAT O\n. O\n\nNadim B-PER\nLadki I-PER\n\nAL-AIN B-LOC\n, O\nUnited B-LOC\nArab I-LOC\nEmirates I-LOC\n1996-12-06 O\n\nJapan B-LOC\nbegan O\nthe O\ndefence O\nof O\ntheir O\nAsian B-MISC\nCup I-MISC\ntitle O\nwith O\na O\nlucky O\n2-1 O\nwin O\nagainst O\nSyria B-LOC\nin O\na O\nGroup O\nC O\nchampionship O\nmatch O\non O\nFriday O\n. O\n\nBut O\nChina B-LOC\nsaw O\ntheir O\nluck O\ndesert O\nthem O\nin O\nthe O\nsecond O\nmatch O\nof O\nthe O\ngroup O\n, O\ncrashing O\nto O\na O\nsurprise O\n2-0 O\ndefeat O\nto O\nnewcomers O\nUzbekistan B-LOC\n. O\n\nChina B-LOC\ncontrolled O\nmost O\nof O\nthe O\nmatch O\nand O\nsaw O\nseveral O\nchances O\nmissed O\nuntil O\nthe O\n78th O\nminute O\nwhen O\nUzbek B-MISC\nstriker O\nIgor B-PER\nShkvyrin I-PER\ntook O\nadvantage O\nof O\na O\nmisdirected O\ndefensive O\nheader O\nto O\nlob O\nthe O\nball O\nover O\nthe O\nadvancing O\nChinese B-MISC\nkeeper O\nand O\ninto O\nan O\nempty O\nnet O\n. O\n\nOleg B-PER\nShatskiku I-PER\nmade O\nsure O\nof O\nthe O\nwin O\nin O\ninjury O\ntime O\n, O\nhitting O\nan O\nunstoppable O\nleft O\nfoot O\nshot O\nfrom O\njust O\noutside O\nthe O\narea O\n. O\n\nThe O\nformer O\nSoviet B-MISC\nrepublic O\nwas O\nplaying O\nin O\nan O\nAsian B-MISC\nCup I-MISC\nfinals O\ntie O\nfor O\nthe O\nfirst O\ntime O\n. O\n\nDespite O\nwinning O\nthe O\nAsian B-MISC\nGames I-MISC\ntitle O\ntwo O\nyears O\nago O\n, O\nUzbekistan B-LOC\nare O\nin O\nthe O\nfinals O\nas O\noutsiders O\n. O\n\nTwo O\ngoals O\nfrom O\ndefensive O\nerrors O\nin O\nthe O\nlast O\nsix O\nminutes O\nallowed O\nJapan B-LOC\nto O\ncome O\nfrom O\nbehind O\nand O\ncollect O\nall O\nthree O\npoints O\nfrom O\ntheir O\nopening O\nmeeting O\nagainst O\nSyria B-LOC\n. O\n\nTakuya B-PER\nTakagi I-PER\nscored O\nthe O\nwinner O\nin O\nthe O\n88th O\nminute O\n, O\nrising O\nto O\nhead O\na O\nHiroshige B-PER\nYanagimoto I-PER\ncross O\ntowards O\nthe O\nSyrian B-MISC\ngoal O\nwhich O\ngoalkeeper O\nSalem B-PER\nBitar I-PER\nappeared O\nto O\nhave O\ncovered O\nbut O\nthen O\nallowed O\nto O\nslip O\ninto O\nthe O\nnet O\n. O\n\nIt O\nwas O\nthe O\nsecond O\ncostly O\nblunder O\nby O\nSyria B-LOC\nin O\nfour O\nminutes O\n. O\n\nDefender O\nHassan B-PER\nAbbas I-PER\nrose O\nto O\nintercept O\na O\nlong O\nball O\ninto O\nthe O\narea O\nin O\nthe O\n84th O\nminute O\nbut O\nonly O\nmanaged O\nto O\ndivert O\nit O\ninto O\nthe O\ntop O\ncorner O\nof O\nBitar B-PER\n's O\ngoal O\n. O\n\nNader B-PER\nJokhadar I-PER\nhad O\ngiven O\nSyria B-LOC\nthe O\nlead O\nwith O\na O\nwell-struck O\nheader O\nin O\nthe O\nseventh O\nminute O\n. O\n\nJapan B-LOC\nthen O\nlaid O\nsiege O\nto O\nthe O\nSyrian B-MISC\npenalty O\narea O\nfor O\nmost O\nof O\nthe O\ngame O\nbut O\nrarely O\nbreached O\nthe O\nSyrian B-MISC\ndefence O\n. O\n\nBitar B-PER\npulled O\noff O\nfine O\nsaves O\nwhenever O\nthey O\ndid O\n. O\n\nJapan B-LOC\ncoach O\nShu B-PER\nKamo I-PER\nsaid O\n: O\n' O\n' O\nThe O\nSyrian B-MISC\nown O\ngoal O\nproved O\nlucky O\nfor O\nus O\n. O\n\nThe O\nSyrians B-MISC\nscored O\nearly O\nand O\nthen O\nplayed O\ndefensively O\nand O\nadopted O\nlong O\nballs O\nwhich O\nmade O\nit O\nhard O\nfor O\nus O\n. O\n' O\n\n' O\n\nJapan B-LOC\n, O\nco-hosts O\nof O\nthe O\nWorld B-MISC\nCup I-MISC\nin O\n2002 O\nand O\nranked O\n20th O\nin O\nthe O\nworld O\nby O\nFIFA B-ORG\n, O\nare O\nfavourites O\nto O\nregain O\ntheir O\ntitle O\nhere O\n. O\n\nHosts O\nUAE B-LOC\nplay O\nKuwait B-LOC\nand O\nSouth B-LOC\nKorea I-LOC\ntake O\non O\nIndonesia B-LOC\non O\nSaturday O\nin O\nGroup O\nA O\nmatches O\n. O\n\nAll O\nfour O\nteams O\nare O\nlevel O\nwith O\none O\npoint O\neach O\nfrom O\none O\ngame O\n. O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nCUTTITTA B-PER\nBACK O\nFOR O\nITALY B-LOC\nAFTER O\nA O\nYEAR O\n. O\n\nROME B-LOC\n1996-12-06 O\n\nItaly B-LOC\nrecalled O\nMarcello B-PER\nCuttitta I-PER\n\non O\nFriday O\nfor O\ntheir O\nfriendly O\nagainst O\nScotland B-LOC\nat O\nMurrayfield B-LOC\nmore O\nthan O\na O\nyear O\nafter O\nthe O\n30-year-old O\nwing O\nannounced O\nhe O\nwas O\nretiring O\nfollowing O\ndifferences O\nover O\nselection O\n. O\n\nCuttitta B-PER\n, O\nwho O\ntrainer O\nGeorge B-PER\nCoste I-PER\nsaid O\nwas O\ncertain O\nto O\nplay O\non O\nSaturday O\nweek O\n, O\nwas O\nnamed O\nin O\na O\n21-man O\nsquad O\nlacking O\nonly O\ntwo O\nof O\nthe O\nteam O\nbeaten O\n54-21 O\nby O\nEngland B-LOC\nat O\nTwickenham B-LOC\nlast O\nmonth O\n. O\n\nStefano B-PER\nBordon I-PER\nis O\nout O\nthrough O\nillness O\nand O\nCoste B-PER\nsaid O\nhe O\nhad O\ndropped O\nback O\nrow O\nCorrado B-PER\nCovi I-PER\n, O\nwho O\nhad O\nbeen O\nrecalled O\nfor O\nthe O\nEngland B-LOC\ngame O\nafter O\nfive O\nyears O\nout O\nof O\nthe O\nnational O\nteam O\n. O\n\nCuttitta B-PER\nannounced O\nhis O\nretirement O\nafter O\nthe O\n1995 B-MISC\nWorld I-MISC\nCup I-MISC\n, O\nwhere O\nhe O\ntook O\nissue O\nwith O\nbeing O\ndropped O\nfrom O\nthe O\nItaly B-LOC\nside O\nthat O\nfaced O\nEngland B-LOC\nin O\nthe O\npool O\nstages O\n. O\n\nCoste B-PER\nsaid O\nhe O\nhad O\napproached O\nthe O\nplayer O\ntwo O\nmonths O\nago O\nabout O\na O\ncomeback O\n. O\n\n\" O\nHe O\nended O\nthe O\nWorld B-MISC\nCup I-MISC\non O\nthe O\nwrong O\nnote O\n, O\n\" O\nCoste B-PER\nsaid O\n. O\n\n\" O\nI O\nthought O\nit O\nwould O\nbe O\nuseful O\nto O\nhave O\nhim O\nback O\nand O\nhe O\nsaid O\nhe O\nwould O\nbe O\navailable O\n. O\n\nI O\nthink O\nnow O\nis O\nthe O\nright O\ntime O\nfor O\nhim O\nto O\nreturn O\n. O\n\" O\n\nSquad O\n: O\nJavier B-PER\nPertile I-PER\n, O\nPaolo B-PER\nVaccari I-PER\n, O\nMarcello B-PER\nCuttitta I-PER\n, O\nIvan B-PER\nFrancescato I-PER\n, O\nLeandro B-PER\nManteri I-PER\n, O\nDiego B-PER\nDominguez I-PER\n, O\nFrancesco B-PER\nMazzariol I-PER\n, O\nAlessandro B-PER\nTroncon I-PER\n, O\nOrazio B-PER\nArancio I-PER\n, O\nAndrea B-PER\nSgorlon I-PER\n, O\nMassimo B-PER\nGiovanelli I-PER\n, O\nCarlo B-PER\nChecchinato I-PER\n, O\nWalter B-PER\nCristofoletto I-PER\n, O\nFranco B-PER\nProperzi I-PER\nCurti I-PER\n, O\nCarlo B-PER\nOrlandi I-PER\n, O\nMassimo B-PER\nCuttitta I-PER\n, O\nGiambatista B-PER\nCroci I-PER\n, O\nGianluca B-PER\nGuidi I-PER\n, O\nNicola B-PER\nMazzucato I-PER\n, O\nAlessandro B-PER\nMoscardi I-PER\n, O\nAndrea B-PER\nCastellani I-PER\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nLATE O\nGOALS O\nGIVE O\nJAPAN B-LOC\nWIN O\nOVER O\nSYRIA B-LOC\n. O\n\nAL-AIN B-LOC\n, O\nUnited B-LOC\nArab I-LOC\nEmirates I-LOC\n1996-12-06 O\n\nTwo O\ngoals O\nin O\nthe O\nlast O\nsix O\nminutes O\ngave O\nholders O\nJapan B-LOC\nan O\nuninspiring O\n2-1 O\nAsian B-MISC\nCup I-MISC\nvictory O\nover O\nSyria B-LOC\non O\nFriday O\n. O\n\nTakuya B-PER\nTakagi I-PER\nheaded O\nthe O\nwinner O\nin O\nthe O\n88th O\nminute O\nof O\nthe O\ngroup O\nC O\ngame O\nafter O\ngoalkeeper O\nSalem B-PER\nBitar I-PER\nspoiled O\na O\nmistake-free O\ndisplay O\nby O\nallowing O\nthe O\nball O\nto O\nslip O\nunder O\nhis O\nbody O\n. O\n\nIt O\nwas O\nthe O\nsecond O\nSyrian B-MISC\ndefensive O\nblunder O\nin O\nfour O\nminutes O\n. O\n\nDefender O\nHassan B-PER\nAbbas I-PER\nrose O\nto O\nintercept O\na O\nlong O\nball O\ninto O\nthe O\narea O\nin O\nthe O\n84th O\nminute O\nbut O\nonly O\nmanaged O\nto O\ndivert O\nit O\ninto O\nthe O\ntop O\ncorner O\nof O\nBitar B-PER\n's O\ngoal O\n. O\n\nSyria B-LOC\nhad O\ntaken O\nthe O\nlead O\nfrom O\ntheir O\nfirst O\nserious O\nattack O\nin O\nthe O\nseventh O\nminute O\n. O\n\nNader B-PER\nJokhadar I-PER\nheaded O\na O\ncross O\nfrom O\nthe O\nright O\nby O\nAmmar B-PER\nAwad I-PER\ninto O\nthe O\ntop O\nright O\ncorner O\nof O\nKenichi B-PER\nShimokawa I-PER\n's O\ngoal O\n. O\n\nJapan B-LOC\nthen O\nlaid O\nsiege O\nto O\nthe O\nSyrian B-MISC\npenalty O\narea O\nand O\nhad O\na O\ngoal O\ndisallowed O\nfor O\noffside O\nin O\nthe O\n16th O\nminute O\n. O\n\nA O\nminute O\nlater O\n, O\nBitar B-PER\nproduced O\na O\ngood O\ndouble O\nsave O\n, O\nfirst O\nfrom O\nKazuyoshi B-PER\nMiura I-PER\n's O\nheader O\nand O\nthen O\nblocked O\na O\nTakagi B-PER\nfollow-up O\nshot O\n. O\n\nBitar B-PER\nsaved O\nwell O\nagain O\nfrom O\nMiura B-PER\nin O\nthe O\n37th O\nminute O\n, O\nparrying O\naway O\nhis O\nheader O\nfrom O\na O\ncorner O\n. O\n\nJapan B-LOC\nstarted O\nthe O\nsecond O\nhalf O\nbrightly O\nbut O\nBitar B-PER\ndenied O\nthem O\nan O\nequaliser O\nwhen O\nhe O\ndived O\nto O\nhis O\nright O\nto O\nsave O\nNaoki B-PER\nSoma I-PER\n's O\nlow O\ndrive O\nin O\nthe O\n53rd O\nminute O\n. O\n\nJapan B-LOC\n: O\n19 O\n- O\nKenichi B-PER\nShimokawa I-PER\n, O\n2 O\n- O\nHiroshige B-PER\nYanagimoto I-PER\n, O\n3 O\n- O\nNaoki B-PER\nSoma I-PER\n, O\n4 O\n- O\nMasami B-PER\nIhara I-PER\n, O\n5 O\n- O\nNorio B-PER\nOmura I-PER\n, O\n6 O\n- O\nMotohiro B-PER\nYamaguchi I-PER\n, O\n8 O\n- O\nMasakiyo B-PER\nMaezono I-PER\n( O\n7 O\n- O\nYasuto B-PER\nHonda I-PER\n71 O\n) O\n, O\n9 O\n- O\nTakuya B-PER\nTakagi I-PER\n, O\n10 O\n- O\nHiroshi B-PER\nNanami I-PER\n, O\n11 O\n- O\nKazuyoshi B-PER\nMiura I-PER\n, O\n15 O\n- O\nHiroaki B-PER\nMorishima I-PER\n( O\n14 O\n- O\nMasayuki B-PER\nOkano I-PER\n75 O\n) O\n. O\n\nSyria B-LOC\n: O\n24 O\n- O\nSalem B-PER\nBitar I-PER\n, O\n3 O\n- O\nBachar B-PER\nSrour I-PER\n; O\n4 O\n- O\nHassan B-PER\nAbbas I-PER\n, O\n5 O\n- O\nTarek B-PER\nJabban I-PER\n, O\n6 O\n- O\nAmmar B-PER\nAwad I-PER\n( O\n9 O\n- O\nLouay B-PER\nTaleb I-PER\n69 O\n) O\n, O\n8 O\n- O\nNihad B-PER\nal-Boushi I-PER\n, O\n10 O\n- O\nMohammed B-PER\nAfash I-PER\n, O\n12 O\n- O\nAli B-PER\nDib I-PER\n, O\n13 O\n- O\nAbdul B-PER\nLatif I-PER\nHelou I-PER\n( O\n17 O\n- O\nAmmar B-PER\nRihawiy I-PER\n46 O\n) O\n, O\n14 O\n- O\nKhaled B-PER\nZaher I-PER\n; O\n16 O\n- O\nNader B-PER\nJokhadar I-PER\n. O\n\n-DOCSTART- O\n\nFREESTYLE O\nSKIING-WORLD B-MISC\nCUP I-MISC\nMOGUL O\nRESULTS O\n. O\n\nTIGNES B-LOC\n, O\nFrance B-LOC\n1996-12-06 O\n\nResults O\nof O\nthe O\nWorld B-MISC\nCup I-MISC\n\nfreestyle O\nskiing O\nmoguls O\ncompetition O\non O\nFriday O\n: O\n\nMen O\n\n1. O\nJesper B-PER\nRonnback I-PER\n( O\nSweden B-LOC\n) O\n25.76 O\npoints O\n\n2. O\nAndrei B-PER\nIvanov I-PER\n( O\nRussia B-LOC\n) O\n24.88 O\n\n3. O\nRyan B-PER\nJohnson I-PER\n( O\nCanada B-LOC\n) O\n24.57 O\n\n4. O\nJean-Luc B-PER\nBrassard I-PER\n( O\nCanada B-LOC\n) O\n24.40 O\n\n5. O\nKorneilus B-PER\nHole I-PER\n( O\nNorway B-LOC\n) O\n23.92 O\n\n6. O\nJeremie B-PER\nCollomb-Patton I-PER\n( O\nFrance B-LOC\n) O\n23.87 O\n\n7. O\nJim B-PER\nMoran I-PER\n( O\nU.S. B-LOC\n) O\n23.25 O\n\n8. O\nDominick B-PER\nGauthier I-PER\n( O\nCanada B-LOC\n) O\n22.73 O\n\n9. O\nJohann B-PER\nGregoire I-PER\n( O\nFrance B-LOC\n) O\n22.58 O\n\n10. O\nTroy B-PER\nBenson I-PER\n( O\nU.S. B-LOC\n) O\n22.56 O\n\nWomen O\n\n1. O\nTatjana B-PER\nMittermayer I-PER\n( O\nGermany B-LOC\n) O\n24.32 O\n\n2. O\nCandice B-PER\nGilg I-PER\n( O\nFrance B-LOC\n) O\n24.31 O\n\n3. O\nMinna B-PER\nKarhu I-PER\n( O\nFinland B-LOC\n) O\n24.05 O\n\n4. O\nTae B-PER\nSatoya I-PER\n( O\nJapan B-LOC\n) O\n23.75 O\n\n5. O\nAnn B-PER\nBattellle I-PER\n( O\nU.S. B-LOC\n) O\n23.56 O\n\n6. O\nDonna B-PER\nWeinbrecht I-PER\n( O\nU.S. B-LOC\n) O\n22.48 O\n\n7. O\nLiz B-PER\nMcIntyre I-PER\n( O\nU.S. B-LOC\n) O\n22.00 O\n\n8. O\nElena B-PER\nKoroleva I-PER\n( O\nRussia B-LOC\n) O\n21.77 O\n\n9. O\nLjudmila B-PER\nDymchenko I-PER\n( O\nRussia B-LOC\n) O\n21.59 O\n\n10. O\nKatleen B-PER\nAllais I-PER\n( O\nFrance B-LOC\n) O\n21.58 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nASIAN B-MISC\nCUP I-MISC\nGROUP O\nC O\nRESULTS O\n. O\n\nAL-AIN B-LOC\n, O\nUnited B-LOC\nArab I-LOC\nEmirates I-LOC\n1996-12-06 O\n\nResults O\nof O\nAsian B-MISC\nCup I-MISC\ngroup O\nC O\nmatches O\nplayed O\non O\nFriday O\n: O\n\nJapan B-LOC\n2 O\nSyria B-LOC\n1 O\n( O\nhalftime O\n0-1 O\n) O\n\nScorers O\n: O\n\nJapan B-LOC\n- O\nHassan B-PER\nAbbas I-PER\n84 O\nown O\ngoal O\n, O\nTakuya B-PER\nTakagi I-PER\n88 O\n. O\n\nSyria B-LOC\n- O\nNader B-PER\nJokhadar I-PER\n7 O\n\nAttendance O\n: O\n10,000 O\n. O\n\nChina B-LOC\n0 O\nUzbekistan B-LOC\n2 O\n( O\nhalftime O\n0-0 O\n) O\n\nScorers O\n: O\nShkvyrin B-PER\nIgor I-PER\n78 O\n, O\nShatskikh B-PER\nOleg I-PER\n90 O\n\nAttendence O\n: O\n3,000 O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nUzbekistan B-LOC\n1 O\n1 O\n0 O\n0 O\n2 O\n0 O\n3 O\n\nJapan B-LOC\n1 O\n1 O\n0 O\n0 O\n2 O\n1 O\n3 O\n\nSyria B-LOC\n1 O\n0 O\n0 O\n1 O\n1 O\n2 O\n0 O\n\nChina B-LOC\n1 O\n0 O\n0 O\n1 O\n0 O\n2 O\n0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\nV O\nNEW B-LOC\nZEALAND I-LOC\nONE-DAY O\nSCOREBOARD O\n. O\n\n[ O\nCORRECTED O\n14:06 O\nGMT B-MISC\n] O\n\nSIALKOT B-LOC\n, O\nPakistan B-LOC\n1996-12-06 O\n\nScoreboard O\nin O\nthe O\nsecond O\n\none-day O\ncricket O\ninternational O\nbetween O\nPakistan B-LOC\nand O\nNew B-LOC\nZealand I-LOC\n\non O\nFriday O\n: O\n\nPakistan B-LOC\n\nSaeed B-PER\nAnwar I-PER\nrun O\nout O\n91 O\n( O\ncorrects O\nfrom O\n90 O\n) O\n\nZahoor B-PER\nElahi I-PER\nb O\nCairns B-PER\n86 O\n( O\ncorrects O\nfrom O\n87 O\n) O\n\nIjaz B-PER\nAhmad I-PER\nc O\nSpearman B-PER\nb O\nVaughan B-PER\n59 O\n\nInzamamul B-PER\nHaq I-PER\nst O\nGermon B-PER\nb O\nAstle B-PER\n2 O\n\nWasim B-PER\nAkram I-PER\nb O\nHarris B-PER\n4 O\n\nShahid B-PER\nAfridi I-PER\nb O\nHarris B-PER\n2 O\n\nMoin B-PER\nKhan I-PER\nc O\nAstle B-PER\nb O\nHarris B-PER\n1 O\n\nWaqar B-PER\nYounis I-PER\nst O\nGermon B-PER\nb O\nHarris B-PER\n0 O\n\nSaqlain B-PER\nMushtaq I-PER\nb O\nHarris B-PER\n2 O\n\nMushtaq B-PER\nAhmad I-PER\nnot O\nout O\n5 O\n\nSalim B-PER\nMalik I-PER\nnot O\nout O\n1 O\n\nExtras O\n( O\nlb-8 O\nnb-2 O\nw-14 O\n) O\n24 O\n\nTotal O\n( O\nfor O\n9 O\nwickets O\nin O\n47 O\novers O\n) O\n277 O\n\nFall O\nof O\nwicket O\n: O\n1-177 O\n( O\ncorrects O\nfrom O\n1-178 O\n) O\n2-225 O\n3-240 O\n4-247 O\n5-252 O\n6-260 O\n7-261 O\n8-269 O\n9-276 O\n\nBowling O\n: O\nDoull B-PER\n8-1-60-0 O\n( O\nw-3 O\n) O\n, O\nKennedy B-PER\n3-0-24-0 O\n( O\nw-7 O\nnb-1 O\n) O\n, O\n\nCairns B-PER\n8-1-35-1 O\n( O\nw-2 O\n) O\n, O\nVaughan B-PER\n9-1-55-1 O\n, O\nHarris B-PER\n10-0-42-5 O\n( O\nw-1 O\n) O\n, O\n\nAstle B-PER\n9-0-53-1 O\n( O\nw-1 O\nnb-1 O\n) O\n\nNew B-LOC\nZealand I-LOC\ninnings O\n\nB. B-PER\nYoung I-PER\nc O\nMoin B-PER\nKhan I-PER\nb O\nWaqar B-PER\n5 O\n\nC. B-PER\nSpearman I-PER\nc O\nMoin B-PER\nKhan I-PER\nb O\nWasim B-PER\n0 O\n\nA. B-PER\nParore I-PER\nc O\nIjaz B-PER\nAhmad I-PER\nb O\nSaqlain B-PER\n37 O\n\nS. B-PER\nFleming I-PER\nc O\nand O\nb O\nAfridi B-PER\n88 O\n\nC. B-PER\nCairns I-PER\nb O\nSaqlain B-PER\n10 O\n\nN. B-PER\nAstle I-PER\nc O\nIjaz B-PER\nAhmad I-PER\nb O\nSalim B-PER\nMalik I-PER\n20 O\n\nC. B-PER\nHarris I-PER\nlbw O\nb O\nWasim B-PER\n22 O\n\nL. B-PER\nGermon I-PER\nlbw O\nb O\nAfridi B-PER\n2 O\n\nJ. B-PER\nVaughan I-PER\nc O\nMoin B-PER\nKhan I-PER\nb O\nWasim B-PER\n13 O\n\nS. B-PER\nDoull I-PER\nc O\nsubs O\n( O\nM. B-PER\nWasim I-PER\n) O\nb O\nWaqar B-PER\n1 O\n\nR. B-PER\nKennedy I-PER\nnot O\nout O\n7 O\n\nExtras O\n( O\nb-9 O\nlb-3 O\nw-12 O\nnb-2 O\n) O\n26 O\n\nTotal O\n( O\nall O\nout O\nin O\n42.1 O\novers O\n) O\n231 O\n\nFall O\nof O\nwickets O\n: O\n1-3 O\n2-7 O\n3-125 O\n4-146 O\n5-170 O\n6-190 O\n7-195 O\n\n8-213 O\n9-216 O\n. O\n\nBowling O\n: O\nWasim B-PER\nAkram I-PER\n8.1-0-43-3 O\n( O\n9w O\n, O\n1nb O\n) O\n, O\nWaqar B-PER\nYounis I-PER\n\n6-0-32-2 O\n( O\n2w O\n, O\n1nb O\n) O\n, O\nSaqlain B-PER\nMushtaq I-PER\n8-0-54-2 O\n, O\nMushtaq B-PER\nAhmad I-PER\n\n10-0-42-0 O\n( O\n1w O\n) O\n, O\nShahid B-PER\nAfridi I-PER\n7-0-40-2 O\n, O\nSalim B-PER\nMalik I-PER\n2.5-0-8-1 O\n, O\n\nIjaz B-PER\nAhmad I-PER\n0.1-0-0-0 O\n. O\n\nResult O\n: O\nPakistan B-LOC\nwon O\nby O\n46 O\nruns O\n. O\n\nThird O\none-day O\nmatch O\n: O\nDecember O\n8 O\n, O\nin O\nKarachi B-LOC\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nF.A. I-MISC\nCUP I-MISC\nSECOND O\nROUND O\nRESULT O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nResult O\nof O\nan O\nEnglish B-MISC\nF.A. I-MISC\nChallenge I-MISC\n\nCup B-MISC\nsecond O\nround O\nmatch O\non O\nFriday O\n: O\n\nPlymouth B-ORG\n4 O\nExeter B-ORG\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBLINKER B-PER\nBAN O\nLIFTED O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nDutch B-MISC\nforward O\nReggie B-PER\nBlinker I-PER\nhad O\nhis O\nindefinite O\nsuspension O\nlifted O\nby O\nFIFA B-ORG\non O\nFriday O\nand O\nwas O\nset O\nto O\nmake O\nhis O\nSheffield B-ORG\nWednesday I-ORG\ncomeback O\nagainst O\nLiverpool B-ORG\non O\nSaturday O\n. O\n\nBlinker B-PER\nmissed O\nhis O\nclub O\n's O\nlast O\ntwo O\ngames O\nafter O\nFIFA B-ORG\nslapped O\na O\nworldwide O\nban O\non O\nhim O\nfor O\nappearing O\nto O\nsign O\ncontracts O\nfor O\nboth O\nWednesday B-ORG\nand O\nUdinese B-ORG\nwhile O\nhe O\nwas O\nplaying O\nfor O\nFeyenoord B-ORG\n. O\n\nFIFA B-ORG\n's O\nplayers O\n' O\nstatus O\ncommittee O\n, O\nmeeting O\nin O\nBarcelona B-LOC\n, O\ndecided O\nthat O\nalthough O\nthe O\nUdinese B-ORG\ndocument O\nwas O\nbasically O\nvalid O\n, O\nit O\ncould O\nnot O\nbe O\nlegally O\nprotected O\n. O\n\nThe O\ncommittee O\nsaid O\nthe O\nItalian B-MISC\nclub O\nhad O\nviolated O\nregulations O\nby O\nfailing O\nto O\ninform O\nFeyenoord B-ORG\n, O\nwith O\nwhom O\nthe O\nplayer O\nwas O\nunder O\ncontract O\n. O\n\nBlinker B-PER\nwas O\nfined O\n75,000 O\nSwiss B-MISC\nfrancs O\n( O\n$ O\n57,600 O\n) O\nfor O\nfailing O\nto O\ninform O\nthe O\nEngllsh B-MISC\nclub O\nof O\nhis O\nprevious O\ncommitment O\nto O\nUdinese B-ORG\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nLEEDS B-ORG\n' O\nBOWYER B-PER\nFINED O\nFOR O\nPART O\nIN O\nFAST-FOOD O\nFRACAS O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nLeeds B-ORG\n' O\nEngland B-LOC\nunder-21 O\nstriker O\nLee B-PER\nBowyer I-PER\nwas O\nfined O\n4,500 O\npounds O\n( O\n$ O\n7,400 O\n) O\non O\nFriday O\nfor O\nhurling O\nchairs O\nat O\nrestaurant O\nstaff O\nduring O\na O\ndisturbance O\nat O\na O\nMcDonald B-ORG\n's I-ORG\nfast-food O\nrestaurant O\n. O\n\nBowyer B-PER\n, O\n19 O\n, O\nwho O\nwas O\ncaught O\nin O\nthe O\nact O\nby O\nsecurity O\ncameras O\n, O\npleaded O\nguilty O\nto O\na O\ncharge O\nof O\naffray O\nat O\na O\ncourt O\nin O\nLondon B-LOC\n. O\n\nHe O\nwas O\nfined O\nand O\nordered O\nto O\npay O\na O\ntotal O\nof O\n175 O\npounds O\nto O\ntwo O\nmembers O\nof O\nstaff O\ninjured O\nin O\nthe O\nfracas O\nin O\nan O\neast O\nLondon B-LOC\nrestaurant O\nin O\nOctober O\n. O\n\nLeeds B-ORG\nhad O\nalready O\nfined O\nBowyer B-PER\n4,000 O\npounds O\n( O\n$ O\n6,600 O\n) O\nand O\nwarned O\nhim O\na O\nrepeat O\nof O\nhis O\ncriminal O\nbehaviour O\ncould O\ncost O\nhim O\nhis O\nplace O\nin O\nthe O\nside O\n. O\n\nBowyer B-PER\n, O\nwho O\nmoved O\nto O\nthe O\nYorkshire B-LOC\nclub O\nin O\nAugust O\nfor O\n3.5 O\nmillion O\npounds O\n( O\n$ O\n5.8 O\nmillion O\n) O\n, O\nwas O\nexpected O\nto O\nplay O\nagainst O\nMiddlesbrough B-ORG\non O\nSaturday O\n. O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nEUROLEAGUE B-MISC\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nStandings O\nin O\nthe O\nmen O\n's O\nEuroLeague B-MISC\n\nbasketball O\nchampionship O\nafter O\nThursday O\n's O\nmatches O\n( O\ntabulate O\nunder O\n\nplayed O\n, O\nwon O\n, O\nlost O\n, O\npoints O\n) O\n: O\n\nGroup O\nA O\n\nCSKA B-ORG\nMoscow I-ORG\n( O\nRussia B-LOC\n9 O\n6 O\n3 O\n15 O\n\nStefanel B-ORG\nMilan I-ORG\n( O\nItaly B-LOC\n) O\n9 O\n6 O\n3 O\n15 O\n\nMaccabi B-ORG\nTel I-ORG\nAviv I-ORG\n( O\nIsrael B-LOC\n) O\n9 O\n5 O\n4 O\n14 O\n\nUlker B-ORG\nSpor I-ORG\n( O\nTurkey B-LOC\n) O\n9 O\n4 O\n5 O\n13 O\n\nLimoges B-ORG\n( O\nFrance B-LOC\n) O\n9 O\n3 O\n6 O\n12 O\n\nPanionios B-ORG\n( O\nGreece B-LOC\n) O\n9 O\n3 O\n6 O\n12 O\n\nGroup O\nB O\n\nTeamsystem B-ORG\nBologna I-ORG\n( O\nItaly B-LOC\n) O\n9 O\n7 O\n2 O\n16 O\n\nOlympiakos B-ORG\n( O\nGreece B-LOC\n) O\n9 O\n5 O\n4 O\n14 O\n\nCibona B-ORG\nZagreb I-ORG\n( O\nCroatia B-LOC\n) O\n9 O\n5 O\n4 O\n14 O\n\nAlba B-ORG\nBerlin I-ORG\n( O\nGermany B-LOC\n) O\n9 O\n5 O\n4 O\n14 O\n\nEstudiantes B-ORG\nMadrid I-ORG\n( O\nSpain B-LOC\n) O\n9 O\n5 O\n4 O\n14 O\n\nCharleroi B-ORG\n( O\nBelgium B-LOC\n) O\n9 O\n0 O\n9 O\n9 O\n\nGroup O\nC O\n\nPanathinaikos B-ORG\n( O\nGreece B-LOC\n) O\n9 O\n7 O\n2 O\n16 O\n\nLjubljana B-ORG\n( O\nSlovenia B-LOC\n) O\n9 O\n6 O\n3 O\n15 O\n\nVilleurbanne B-ORG\n( O\nFrance B-LOC\n) O\n9 O\n6 O\n3 O\n15 O\n\nBarcelona B-ORG\n( O\nSpain B-LOC\n) O\n9 O\n4 O\n5 O\n13 O\n\nSplit B-ORG\n( O\nCroatia B-LOC\n) O\n9 O\n4 O\n5 O\n13 O\n\nBayer B-ORG\nLeverkusen I-ORG\n( O\nGermany B-LOC\n) O\n9 O\n0 O\n9 O\n9 O\n\nGroup O\nD O\n\nEfes B-ORG\nPilsen I-ORG\n( O\nTurkey B-LOC\n) O\n9 O\n7 O\n2 O\n16 O\n\nPau-Orthez B-ORG\n( O\nFrance B-LOC\n) O\n9 O\n5 O\n4 O\n14 O\n\nPartizan B-ORG\nBelgrade I-ORG\n( O\nYugoslavia B-LOC\n) O\n9 O\n5 O\n4 O\n14 O\n\nKinder B-ORG\nBologna I-ORG\n( O\nItaly B-LOC\n) O\n9 O\n4 O\n5 O\n13 O\n\nSevilla B-ORG\n( O\nSpain B-LOC\n) O\n9 O\n4 O\n5 O\n13 O\n\nDynamo B-ORG\nMoscow I-ORG\n( O\nRussia B-LOC\n) O\n9 O\n2 O\n7 O\n11 O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nLITTLE B-PER\nTO O\nMISS O\nCAMPESE B-PER\nFAREWELL O\n. O\n\nRobert B-PER\nKitson I-PER\n\nLONDON B-LOC\n1996-12-06 O\n\nCentre O\nJason B-PER\nLittle I-PER\nwill O\nmiss O\nAustralia B-LOC\n's O\nend-of-tour O\nfixture O\nagainst O\nthe O\nBarbarians B-ORG\nat O\nTwickenham B-LOC\non O\nSaturday O\n. O\n\nLittle B-PER\nhas O\nopted O\nnot O\nto O\nrisk O\naggravating O\nthe O\nknee O\ninjury O\nwhich O\nruled O\nhim O\nout O\nof O\na O\nlarge O\nchunk O\nof O\nthe O\ntour O\nand O\nis O\nreplaced O\nby O\nfellow O\nQueenslander B-MISC\nDaniel B-PER\nHerbert I-PER\n. O\n\nOwen B-PER\nFinegan I-PER\nhas O\nrecovered O\nfrom O\nthe O\nknocks O\nhe O\ntook O\nin O\nlast O\nweekend O\n's O\ntest O\nagainst O\nWales B-LOC\nand O\nretains O\nhis O\nplace O\nin O\nthe O\nback-row O\nahead O\nof O\nDaniel B-PER\nManu I-PER\n. O\n\nThe O\nWallabies B-ORG\nhave O\ntheir O\nsights O\nset O\non O\na O\n13th O\nsuccessive O\nvictory O\nto O\nend O\ntheir O\nEuropean B-MISC\ntour O\nwith O\na O\n100 O\npercent O\nrecord O\nbut O\nalso O\nwant O\nto O\nturn O\non O\nthe O\nstyle O\nand O\nprovide O\nDavid B-PER\nCampese I-PER\nwith O\na O\nfitting O\nsend-off O\nin O\nhis O\nfinal O\nmatch O\nin O\nAustralian B-MISC\ncolours O\n. O\n\nThe O\nWallabies B-ORG\ncurrently O\nhave O\nno O\nplans O\nto O\nmake O\nany O\nspecial O\npresentation O\nto O\nthe O\n34-year-old O\nwinger O\nbut O\na O\nfull O\nhouse O\nof O\n75,000 O\nspectators O\nwill O\nstill O\ngather O\nin O\nthe O\nhope O\nof O\nwitnessing O\none O\nlast O\nmoment O\nof O\nmagic O\n. O\n\nCampese B-PER\nwill O\nbe O\nup O\nagainst O\na O\nfamiliar O\nfoe O\nin O\nthe O\nshape O\nof O\nBarbarians B-ORG\ncaptain O\nRob B-PER\nAndrew I-PER\n, O\nthe O\nman O\nwho O\nkicked O\nAustralia B-LOC\nto O\ndefeat O\nwith O\na O\nlast-ditch O\ndrop-goal O\nin O\nthe O\nWorld B-MISC\nCup I-MISC\nquarter-final O\nin O\nCape B-LOC\nTown I-LOC\n. O\n\n\" O\nCampo B-PER\nhas O\na O\nmassive O\nfollowing O\nin O\nthis O\ncountry O\nand O\nhas O\nhad O\nthe O\npublic O\nwith O\nhim O\never O\nsince O\nhe O\nfirst O\nplayed O\nhere O\nin O\n1984 O\n, O\n\" O\nsaid O\nAndrew B-PER\n, O\nalso O\nlikely O\nto O\nbe O\nmaking O\nhis O\nfinal O\nTwickenham B-LOC\nappearance O\n. O\n\nOn O\ntour O\n, O\nAustralia B-LOC\nhave O\nwon O\nall O\nfour O\ntests O\nagainst O\nItaly B-LOC\n, O\nScotland B-LOC\n, O\nIreland B-LOC\nand O\nWales B-LOC\n, O\nand O\nscored O\n414 O\npoints O\nat O\nan O\naverage O\nof O\nalmost O\n35 O\npoints O\na O\ngame O\n. O\n\nLeague O\nduties O\nrestricted O\nthe O\nBarbarians B-ORG\n' O\nselectorial O\noptions O\nbut O\nthey O\nstill O\nboast O\n13 O\ninternationals O\nincluding O\nEngland B-LOC\nfull-back O\nTim B-PER\nStimpson I-PER\nand O\nrecalled O\nwing O\nTony B-PER\nUnderwood I-PER\n, O\nplus O\nAll B-ORG\nBlack I-ORG\nforwards O\nIan B-PER\nJones I-PER\nand O\nNorm B-PER\nHewitt I-PER\n. O\n\nTeams O\n: O\n\nBarbarians B-ORG\n- O\n15 O\n- O\nTim B-PER\nStimpson I-PER\n( O\nEngland B-LOC\n) O\n; O\n14 O\n- O\nNigel B-PER\nWalker I-PER\n( O\nWales B-LOC\n) O\n, O\n13 O\n- O\nAllan B-PER\nBateman I-PER\n( O\nWales B-LOC\n) O\n, O\n12 O\n- O\nGregor B-PER\nTownsend I-PER\n( O\nScotland B-LOC\n) O\n, O\n11 O\n- O\nTony B-PER\nUnderwood I-PER\n( O\nEngland B-LOC\n) O\n; O\n10 O\n- O\nRob B-PER\nAndrew I-PER\n( O\nEngland B-LOC\n) O\n, O\n9 O\n- O\nRob B-PER\nHowley I-PER\n( O\nWales B-LOC\n) O\n; O\n8 O\n- O\nScott B-PER\nQuinnell I-PER\n( O\nWales B-LOC\n) O\n, O\n7 O\n- O\nNeil B-PER\nBack I-PER\n( O\nEngland B-LOC\n) O\n, O\n6 O\n- O\nDale B-PER\nMcIntosh I-PER\n( O\nPontypridd B-LOC\n) O\n, O\n5 O\n- O\nIan B-PER\nJones I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n, O\n4 O\n- O\nCraig B-PER\nQuinnell I-PER\n( O\nWales B-LOC\n) O\n, O\n3 O\n- O\nDarren B-PER\nGarforth I-PER\n( O\nLeicester B-LOC\n) O\n, O\n2 O\n- O\nNorm B-PER\nHewitt I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n, O\n1 O\n- O\nNick B-PER\nPopplewell I-PER\n( O\nIreland B-LOC\n) O\n. O\n\nAustralia B-LOC\n- O\n15 O\n- O\nMatthew B-PER\nBurke I-PER\n; O\n14 O\n- O\nJoe B-PER\nRoff I-PER\n, O\n13 O\n- O\nDaniel B-PER\nHerbert I-PER\n, O\n12 O\n- O\nTim B-PER\nHoran I-PER\n( O\ncaptain O\n) O\n, O\n11 O\n- O\nDavid B-PER\nCampese I-PER\n; O\n10 O\n- O\nPat B-PER\nHoward I-PER\n, O\n9 O\n- O\nSam B-PER\nPayne I-PER\n; O\n8 O\n- O\nMichael B-PER\nBrial I-PER\n, O\n7 O\n- O\nDavid B-PER\nWilson I-PER\n, O\n6 O\n- O\nOwen B-PER\nFinegan I-PER\n, O\n5 O\n- O\nDavid B-PER\nGiffin I-PER\n, O\n4 O\n- O\nTim B-PER\nGavin I-PER\n, O\n3 O\n- O\nAndrew B-PER\nBlades I-PER\n, O\n2 O\n- O\nMarco B-PER\nCaputo I-PER\n, O\n1 O\n- O\nDan B-PER\nCrowley I-PER\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nZIMBABWE B-MISC\nOPEN I-MISC\nSECOND O\nROUND O\nSCORES O\n. O\n\nHARARE B-LOC\n1996-12-06 O\n\nLeading O\nsecond O\nround O\nscores O\nin O\nthe O\nZimbabwe B-MISC\nOpen I-MISC\nat O\nthe O\npar-72 O\nChapman B-LOC\nGolf I-LOC\nClub I-LOC\non O\nFriday O\n( O\nSouth B-MISC\nAfrican I-MISC\nunless O\nstated O\n) O\n: O\n132 O\nDes B-PER\nTerblanche I-PER\n65 O\n67 O\n133 O\nMark B-PER\nMcNulty I-PER\n( O\nZimbabwe B-LOC\n) O\n72 O\n61 O\n134 O\nSteve B-PER\nvan I-PER\nVuuren I-PER\n65 O\n69 O\n136 O\nNick B-PER\nPrice I-PER\n( O\nZimbabwe B-LOC\n) O\n68 O\n68 O\n, O\nJustin B-PER\nHobday I-PER\n71 O\n65 O\n, O\n\nAndrew B-PER\nPitts I-PER\n( O\nU.S. B-LOC\n) O\n69 O\n67 O\n138 O\nMark B-PER\nCayeux I-PER\n( O\nZimbabwe B-LOC\n) O\n69 O\n69 O\n, O\nMark B-PER\nMurless I-PER\n71 O\n67 O\n139 O\nHennie B-PER\nSwart I-PER\n75 O\n64 O\n, O\nAndrew B-PER\nPark I-PER\n72 O\n67 O\n140 O\nSchalk B-PER\nvan I-PER\nder I-PER\nMerwe I-PER\n( O\nNamibia B-LOC\n) O\n67 O\n73 O\n, O\nDesvonde B-PER\n\nBotes B-PER\n72 O\n68 O\n, O\nGreg B-PER\nReid I-PER\n72 O\n68 O\n, O\nClinton B-PER\nWhitelaw I-PER\n70 O\n\n70 O\n, O\nBrett B-PER\nLiddle I-PER\n75 O\n65 O\n, O\nHugh B-PER\nBaiocchi I-PER\n73 O\n67 O\n141 O\nAdilson B-PER\nda I-PER\nSilva I-PER\n( O\nBrazil B-LOC\n) O\n72 O\n69 O\n, O\nSammy B-PER\nDaniels I-PER\n73 O\n\n68 O\n, O\nTrevor B-PER\nDodds I-PER\n( O\nNamibia B-LOC\n) O\n72 O\n69 O\n142 O\nDon B-PER\nRobertson I-PER\n( O\nU.S. B-LOC\n) O\n73 O\n69 O\n, O\nDion B-PER\nFourie I-PER\n69 O\n73 O\n, O\n\nSteve B-PER\nWaltman I-PER\n72 O\n70 O\n, O\nIan B-PER\nDougan I-PER\n73 O\n69 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nUNCAPPED O\nPLAYERS O\nCALLED O\nTO O\nFACE O\nMACEDONIA B-LOC\n. O\n\nBUCHAREST B-LOC\n1996-12-06 O\n\nRomania B-LOC\ntrainer O\nAnghel B-PER\nIordanescu I-PER\ncalled O\nup O\nthree O\nuncapped O\nplayers O\non O\nFriday O\nin O\nhis O\nsquad O\nto O\nface O\nMacedonia B-LOC\nnext O\nweek O\nin O\na O\nWorld B-MISC\nCup I-MISC\nqualifier O\n. O\n\nMidfielder O\nValentin B-PER\nStefan I-PER\nand O\nstriker O\nViorel B-PER\nIon I-PER\nof O\nOtelul B-ORG\nGalati I-ORG\nand O\ndefender O\nLiviu B-PER\nCiobotariu I-PER\nof O\nNational B-ORG\nBucharest I-ORG\nare O\nthe O\nnewcomers O\nfor O\nthe O\nEuropean B-MISC\ngroup O\neight O\nclash O\nin O\nMacedonia B-LOC\non O\nDecember O\n14 O\n. O\n\nIordanescu B-PER\nsaid O\nhe O\nhad O\npicked O\nthem O\nbecause O\nof O\ntheir O\ngood O\nperformances O\nin O\nthe O\ndomestic O\nchampionship O\nin O\nwhich O\nNational B-ORG\nBucharest I-ORG\nare O\ntop O\nand O\nOtelul B-ORG\nGalati I-ORG\nthird O\n. O\n\" O\n\nI O\nthink O\nit O\n's O\nfair O\nto O\ngive O\nthem O\na O\nchance O\n, O\n\" O\nhe O\ntold O\nreporters O\n. O\n\nLeague O\ntitle-holders O\nSteaua B-ORG\nBucharest I-ORG\n, O\nwho O\nfinished O\nbottom O\nof O\ntheir O\nChampions B-MISC\n' I-MISC\nLeague I-MISC\ngroup O\nin O\nthe O\nEuropean B-MISC\nCup I-MISC\n, O\nhave O\nonly O\ntwo O\nplayers O\nin O\nthe O\nsquad O\n. O\n\nAttacking O\nmidfielder O\nAdrian B-PER\nIlie I-PER\n, O\nwho O\nrecently O\nmoved O\nfrom O\nSteaua B-ORG\nto O\nTurkish B-MISC\nclub O\nGalatasaray B-ORG\n, O\nis O\nruled O\nout O\nafter O\ntwo O\nyellow-card O\noffences O\n. O\n\nSquad O\n: O\n\nGoalkeepers O\n- O\nBogdan B-PER\nStelea I-PER\n, O\nFlorin B-PER\nPrunea I-PER\n. O\n\nDefenders O\n- O\nDan B-PER\nPetrescu I-PER\n, O\nDaniel B-PER\nProdan I-PER\n, O\nAnton B-PER\nDobos I-PER\n, O\nCornel B-PER\nPapura I-PER\n, O\nLiviu B-PER\nCiobotariu I-PER\n, O\nTibor B-PER\nSelymess I-PER\n, O\nIulian B-PER\nFilipescu I-PER\n. O\n\nMidfielders O\n- O\nGheorghe B-PER\nHagi I-PER\n, O\nGheorghe B-PER\nPopescu I-PER\n, O\nConstantin B-PER\nGalca I-PER\n, O\nValentin B-PER\nStefan I-PER\n, O\nBasarab B-PER\nPanduru I-PER\n, O\nDorinel B-PER\nMunteanu I-PER\n, O\nOvidiu B-PER\nStinga I-PER\n. O\n\nForwards O\n- O\nIoan B-PER\nVladoiu I-PER\n, O\nGheorghe B-PER\nCraioveanu I-PER\n, O\nIonel B-PER\nDanciulescu I-PER\n, O\nViorel B-PER\nIon I-PER\n. O\n\nREUTER B-ORG\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBRAZILIAN B-MISC\nCHAMPIONSHIP O\nRESULTS O\n. O\n\nRIO B-LOC\nDE I-LOC\nJANEIRO I-LOC\n1996-12-05 O\n\nResults O\nof O\nBrazilian B-MISC\n\nsoccer O\nchampionship O\nsemifinal O\n, O\nfirst O\nleg O\nmatches O\non O\nThursday O\n. O\n\nGoias B-ORG\n1 O\nGremio B-ORG\n3 O\n\nPortuguesa B-ORG\n1 O\nAtletico B-ORG\nMineiro I-ORG\n0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nLARA B-PER\nENDURES O\nANOTHER O\nMISERABLE O\nDAY O\n. O\n\nRobert B-PER\nGalvin I-PER\n\nMELBOURNE B-LOC\n1996-12-06 O\n\nAustralia B-LOC\ngave O\nBrian B-PER\nLara I-PER\nanother O\nreason O\nto O\nbe O\nmiserable O\nwhen O\nthey O\nbeat O\nWest B-LOC\nIndies I-LOC\nby O\nfive O\nwickets O\nin O\nthe O\nopening O\nWorld B-MISC\nSeries I-MISC\nlimited O\novers O\nmatch O\non O\nFriday O\n. O\n\nLara B-PER\n, O\ndisciplined O\nfor O\nmisconduct O\non O\nWednesday O\n, O\nwas O\ndismissed O\nfor O\nfive O\nto O\nextend O\na O\ndisappointing O\nrun O\nof O\nform O\non O\ntour O\n. O\n\nAustralia B-LOC\n, O\nwho O\nhold O\na O\n2-0 O\nlead O\nin O\nthe O\nfive-match O\ntest O\nseries O\n, O\noverhauled O\nWest B-LOC\nIndies I-LOC\n' O\ntotal O\nof O\n172 O\nall O\nout O\nwith O\neight O\nballs O\nto O\nspare O\nto O\nend O\na O\nrun O\nof O\nsix O\nsuccessive O\none-day O\ndefeats O\n. O\n\nAll-rounder O\nGreg B-PER\nBlewett I-PER\nsteered O\nhis O\nside O\nto O\na O\ncomfortable O\nvictory O\nwith O\nan O\nunbeaten O\n57 O\nin O\n90 O\nballs O\nto O\nthe O\ndelight O\nof O\nthe O\n42,442 O\ncrowd O\n. O\n\nMan-of-the O\nmatch O\nBlewett B-PER\ncame O\nto O\nthe O\nwicket O\nwith O\nthe O\ntotal O\non O\n70 O\nfor O\ntwo O\nand O\nhit O\nthree O\nfours O\nduring O\nan O\nuntroubled O\ninnings O\nlasting O\n129 O\nminutes O\n. O\n\nHis O\ncrucial O\nfifth-wicket O\npartnership O\nwith O\nfellow O\nall-rounder O\nStuart B-PER\nLaw I-PER\n, O\nwho O\nscored O\n21 O\n, O\nadded O\n71 O\noff O\n85 O\nballs O\n. O\n\nLara B-PER\nlooked O\nout O\nof O\ntouch O\nduring O\nhis O\nbrief O\nstay O\nat O\nthe O\ncrease O\nbefore O\nchipping O\na O\nsimple O\ncatch O\nto O\nShane B-PER\nWarne I-PER\nat O\nmid-wicket O\n. O\n\nWest B-LOC\nIndies I-LOC\ntour O\nmanager O\nClive B-PER\nLloyd I-PER\nhas O\napologised O\nfor O\nLara B-PER\n's O\nbehaviour O\non O\nTuesday O\n. O\n\nHe O\n( O\nLara B-PER\n) O\nhad O\ntold O\nAustralia B-LOC\ncoach O\nGeoff B-PER\nMarsh I-PER\nthat O\nwicketkeeper O\nIan B-PER\nHealy I-PER\nwas O\nunwelcome O\nin O\nthe O\nvisitors O\n' O\ndressing O\nroom O\n. O\n\nThe O\nMelbourne B-LOC\ncrowd O\nwere O\nclearly O\nangered O\nby O\nthe O\nincident O\n, O\nloudly O\njeering O\nthe O\nWest B-LOC\nIndies I-LOC\nvice-captain O\nas O\nhe O\nwalked O\nto O\nthe O\nmiddle O\n. O\n\nIt O\nwas O\nleft O\nto O\nfellow O\nleft-hander O\nShivnarine B-PER\nChanderpaul I-PER\nto O\nhold O\nthe O\ninnings O\ntogether O\nwith O\na O\ngritty O\n54 O\ndespite O\nthe O\nhandicap O\nof O\nan O\ninjured O\ngroin O\n. O\n\nChanderpaul B-PER\nwas O\nforced O\nto O\nrely O\non O\na O\nrunner O\nfor O\nmost O\nof O\nhis O\ninnings O\nafter O\nhurting O\nhimself O\nas O\nhe O\nscurried O\nback O\nto O\nhis O\ncrease O\nto O\navoid O\nbeing O\nrun O\nout O\n. O\n\nPakistan B-LOC\n, O\nwho O\narrive O\nin O\nAustralia B-LOC\nlater O\nthis O\nmonth O\n, O\nare O\nthe O\nother O\nteam O\ncompeting O\nin O\nthe O\nWorld B-MISC\nSeries I-MISC\ntournament O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nAUSTRALIA B-LOC\nV O\nWEST B-LOC\nINDIES I-LOC\nWORLD B-MISC\nSERIES I-MISC\nSCOREBOARD O\n. O\n\nMELBOURNE B-LOC\n1996-12-06 O\n\nScoreboard O\nin O\nthe O\nWorld B-MISC\nSeries I-MISC\n\nlimited O\novers O\nmatch O\nbetween O\nAustralia B-LOC\nand O\nWest B-LOC\nIndies I-LOC\non O\nFriday O\n: O\n\nWest B-LOC\nIndies I-LOC\n\nS. B-PER\nCampbell I-PER\nc O\nHealy B-PER\nb O\nGillespie B-PER\n31 O\n\nR. B-PER\nSamuels I-PER\nc O\nM. B-PER\nWaugh I-PER\nb O\nGillespie B-PER\n7 O\n\nB. B-PER\nLara I-PER\nc O\nWarne B-PER\nb O\nMoody B-PER\n5 O\n\nS. B-PER\nChanderpaul I-PER\nc O\nHealy B-PER\nb O\nBlewett B-PER\n54 O\n\nC. B-PER\nHooper I-PER\nrun O\nout O\n7 O\n\nJ. B-PER\nAdams I-PER\nlbw O\nb O\nMoody B-PER\n5 O\n\nJ. B-PER\nMurray I-PER\nc O\nBlewett B-PER\nb O\nWarne B-PER\n24 O\n\nN. B-PER\nMcLean I-PER\nc O\nand O\nb O\nM. B-PER\nWaugh I-PER\n7 O\n\nK. B-PER\nBenjamin I-PER\nb O\nWarne B-PER\n8 O\n\nC. B-PER\nAmbrose I-PER\nrun O\nout O\n2 O\n\nC. B-PER\nWalsh I-PER\nnot O\nout O\n8 O\n\nExtras O\n( O\nlb-10 O\nw-1 O\nnb-3 O\n) O\n14 O\n\nTotal O\n( O\n49.2 O\novers O\n) O\n172 O\n\nFall O\nof O\nwickets O\n: O\n1-11 O\n2-38 O\n3-64 O\n4-73 O\n5-81 O\n6-120 O\n7-135 O\n8-150 O\n\n9-153 O\n. O\n\nBowling O\n: O\nReiffel B-PER\n10-2-26-0 O\n( O\nnb-3 O\n) O\n, O\nGillespie B-PER\n10-0-39-2 O\n, O\n\nMoody B-PER\n10-1-25-2 O\n, O\nBlewett B-PER\n6.2-0-27-1 O\n, O\nWarne B-PER\n10-0-34-2 O\n( O\nw-1 O\n) O\n, O\n\nM. B-PER\nWaugh I-PER\n3-0-11-1 O\n. O\n\nAustralia B-LOC\n\nM. B-PER\nTaylor I-PER\nb O\nMcLean B-PER\n29 O\n\nM. B-PER\nWaugh I-PER\nc O\nMurray B-PER\nb O\nBenjamin B-PER\n27 O\n\nR. B-PER\nPonting I-PER\nlbw O\nMcLean B-PER\n5 O\n\nG. B-PER\nBlewett I-PER\nnot O\nout O\n57 O\n\nM. B-PER\nBevan I-PER\nst O\nMurray B-PER\nb O\nHooper B-PER\n3 O\n\nS. B-PER\nLaw I-PER\nb O\nHooper B-PER\n21 O\n\nT. B-PER\nMoody I-PER\nnot O\nout O\n3 O\n\nExtras O\n( O\nlb-17 O\nnb-8 O\nw-3 O\n) O\n28 O\n\nTotal O\n( O\nfor O\nfive O\nwickets O\n, O\n48.4 O\novers O\n) O\n173 O\n\nFall O\nof O\nwickets O\n: O\n1-59 O\n2-70 O\n3-78 O\n4-90 O\n5-160 O\n. O\n\nDid O\nnot O\nbat O\n: O\nI. B-PER\nHealy I-PER\n, O\nP. B-PER\nReiffel I-PER\n, O\nS. B-PER\nWarne I-PER\n, O\nJ. B-PER\nGillespie I-PER\n. O\n\nBowling O\n: O\nAmbrose B-PER\n10-3-19-0 O\n( O\n2nb O\n1w O\n) O\n, O\nWalsh B-PER\n9-0-34-0 O\n( O\n4nb O\n) O\n, O\n\nBenjamin B-PER\n9.4-0-43-1 O\n( O\n1nb O\n1w O\n) O\n, O\nHooper B-PER\n10-0-27-2 O\n( O\n1nb O\n) O\n, O\nMcLean B-PER\n\n10-1-33-2 O\n( O\n1w O\n) O\n. O\n\nResult O\n: O\nAustralia B-LOC\nwon O\nby O\nfive O\nwickets O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nAUSTRALIA B-LOC\nBEAT O\nWEST B-LOC\nINDIES I-LOC\nBY O\nFIVE O\nWICKETS O\n. O\n\nMELBOURNE B-LOC\n1996-12-06 O\n\nAustralia B-LOC\nbeat O\nWest B-LOC\nIndies I-LOC\nby O\nfive O\nwickets O\nin O\na O\nWorld B-MISC\nSeries I-MISC\nlimited O\novers O\nmatch O\nat O\nthe O\nMelbourne B-LOC\nCricket I-LOC\nGround I-LOC\non O\nFriday O\n. O\n\nScores O\n: O\nWest B-LOC\nIndies I-LOC\n172 O\nall O\nout O\nin O\n49.2 O\novers O\n( O\nShivnarine B-PER\nChanderpaul I-PER\n54 O\n) O\n; O\nAustralia B-LOC\n173-5 O\nin O\n48.4 O\novers O\n( O\nGreg B-PER\nBlewett I-PER\n57 O\nnot O\nout O\n) O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nWEST B-LOC\nINDIES I-LOC\n172 O\nALL O\nOUT O\nIN O\n49.2 O\nOVERS O\nV O\nAUSTRALIA B-LOC\n. O\n\nMELBOURNE B-LOC\n1996-12-06 O\n\nWest B-LOC\nIndies I-LOC\nwere O\nall O\nout O\nfor O\n172 O\noff O\n49.2 O\novers O\nin O\nthe O\nWorld B-MISC\nSeries I-MISC\nlimited O\novers O\nmatch O\nagainst O\nAustralia B-LOC\non O\nFriday O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nSHEFFIELD B-MISC\nSHIELD I-MISC\nSCORE O\n. O\n\nHOBART B-LOC\n, O\nAustralia B-LOC\n1996-12-06 O\n\nScore O\non O\nthe O\nfirst O\nday O\nof O\nthe O\nfour-day O\nSheffield B-MISC\nShield I-MISC\nmatch O\nbetween O\nTasmania B-LOC\nand O\nVictoria B-LOC\nat O\nBellerive B-LOC\nOval I-LOC\non O\nFriday O\n: O\n\nTasmania B-LOC\n352 O\nfor O\nthree O\n( O\nDavid B-PER\nBoon I-PER\n106 O\nnot O\nout O\n, O\nShaun B-PER\nYoung I-PER\n86 O\nnot O\nout O\n, O\nMichael B-PER\nDiVenuto I-PER\n119 O\n) O\nv O\nVictoria B-ORG\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nLARA B-PER\nSUFFERS O\nMORE O\nAUSTRALIAN O\nTOUR O\nMISERY O\n. O\n\nMELBOURNE B-LOC\n1996-12-06 O\n\nWest B-LOC\nIndies I-LOC\nbatsman O\nBrian B-PER\nLara I-PER\nsuffered O\nanother O\nblow O\nto O\nhis O\nAustralian B-MISC\ntour O\n, O\nafter O\nalready O\nbeing O\ndisciplined O\nfor O\nmisconduct O\n, O\nwhen O\nhe O\nwas O\ndismissed O\ncheaply O\nin O\nthe O\nfirst O\nlimited O\novers O\nmatch O\nagainst O\nAustralia B-LOC\non O\nFriday O\n. O\n\nLara B-PER\n, O\nwho O\nearned O\na O\nstern O\nrebuke O\nfrom O\nhis O\nown O\ntour O\nmanagement O\nafter O\nan O\nangry O\noutburst O\nagainst O\nAustralia B-LOC\nwicketkeeper O\nIan B-PER\nHealy I-PER\n, O\nscored O\nfive O\nto O\nprolong O\na O\nrun O\nof O\npoor O\nform O\nwith O\nthe O\nbat O\n. O\n\nThe O\nWest B-LOC\nIndies I-LOC\nvice-captain O\nstruggled O\nfor O\ntiming O\nduring O\nhis O\n36-minute O\nstay O\nat O\nthe O\ncrease O\nbefore O\nchipping O\na O\nball O\nfrom O\nmedium O\npacer O\nTom B-PER\nMoody I-PER\nstraight O\nto O\nShane B-PER\nWarne I-PER\nat O\nmid-wicket O\n. O\n\nWest B-LOC\nIndies I-LOC\nwere O\n53 O\nfor O\ntwo O\nin O\n15 O\novers O\nwhen O\nrain O\nstopped O\nplay O\nat O\nthe O\nMelbourne B-LOC\nCricket I-LOC\nGround I-LOC\nafter O\ncaptain O\nCourtney B-PER\nWalsh I-PER\nwon O\nthe O\ntoss O\nand O\nelected O\nto O\nbat O\n. O\n\nLara B-PER\n's O\noutburst O\nthree O\ndays O\nago O\nhas O\nclearly O\nturned O\nsome O\nof O\nthe O\nAustralian B-MISC\npublic O\nagainst O\nhim O\n. O\n\nAs O\nhe O\nwalked O\nto O\nthe O\nwicket O\nhe O\nwas O\ngreeted O\nby O\nloud O\njeers O\nfrom O\nsections O\nof O\nthe O\ncrowd O\n. O\n\nOn O\nseveral O\noccasions O\nduring O\nhis O\ninnings O\n, O\nthe O\ncrowd O\njoined O\ntogether O\nin O\na O\nseries O\nof O\nobscene O\nchants O\nagainst O\nhim O\n. O\n\nTour O\nmanager O\nClive B-PER\nLloyd I-PER\non O\nWednesday O\napologised O\nfor O\nLara B-PER\n's O\nbehaviour O\nin O\nconfronting O\nAustralia B-LOC\ncoach O\nGeoff B-PER\nMarsh I-PER\nin O\nthe O\nopposition O\ndressing O\nroom O\nto O\nprotest O\nagainst O\nhis O\ndismissal O\nin O\nthe O\nsecond O\ntest O\non O\nTuesday O\n. O\n\nLloyd B-PER\ndid O\nnot O\nsay O\nwhat O\nform O\nthe O\ndiscipline O\nwould O\ntake O\n. O\n\nLara B-PER\n, O\nwho O\nholds O\nthe O\nrecord O\nfor O\nthe O\nhighest O\nscore O\nin O\ntest O\nand O\nfirst-class O\ncricket O\n, O\nwas O\nunhappy O\nabout O\nHealy B-PER\n's O\nrole O\nin O\nthe O\nincident O\nand O\nquestioned O\nwhether O\nthe O\nball O\nhad O\ncarried O\nto O\nthe O\nAustralia B-LOC\nkeeper O\n. O\n\nAustralia B-LOC\nwent O\non O\nto O\nwin O\nthe O\nmatch O\nat O\nthe O\nSydney B-LOC\nCricket I-LOC\nGround I-LOC\nby O\n124 O\nruns O\nto O\ntake O\na O\ntwo-nil O\nlead O\nin O\nthe O\nfive-test O\nseries O\nafter O\nLara B-PER\nfailed O\nin O\nboth O\ninnings O\n. O\n\nLara B-PER\nhas O\nyet O\nto O\nscore O\na O\ncentury O\nsince O\nWest B-LOC\nIndies I-LOC\narrived O\nin O\nAustralia B-LOC\nfive O\nweeks O\nago O\n. O\n\nBoth O\nWest B-LOC\nIndies I-LOC\nand O\nAustralia B-LOC\nteam O\nmanagement O\nhave O\nplayed O\ndown O\nthe O\nincident O\n, O\nstressing O\nthat O\nrelations O\nbetween O\nthe O\ntwo O\nsides O\nhave O\nnot O\nbeen O\nadversely O\naffected O\n. O\n\nPakistan B-LOC\n, O\nwho O\narrive O\nnext O\nweek O\n, O\nare O\nthe O\nthird O\nteam O\nin O\nthe O\ntriangular O\nWorld B-MISC\nSeries I-MISC\ntournament O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nWEST B-LOC\nINDIES I-LOC\nTO O\nBAT O\nAFTER O\nWINNING O\nTHE O\nTOSS O\n. O\n\nMELBOURNE B-LOC\n1996-12-06 O\n\nWest B-LOC\nIndies I-LOC\ncaptain O\nCourtney B-PER\nWalsh I-PER\nelected O\nto O\nbat O\nafter O\nwinning O\nthe O\ntoss O\nin O\nthe O\nfirst O\nmatch O\nin O\nthe O\nWorld B-MISC\nSeries I-MISC\nlimited O\novers O\ncompetition O\nagainst O\nAustralia B-LOC\nat O\nthe O\nMelbourne B-LOC\nCricket O\nGround O\non O\nFriday O\n. O\n\nTeams O\n: O\n\nAustralia B-LOC\n- O\nMark B-PER\nTaylor I-PER\n( O\ncaptain O\n) O\n, O\nMark B-PER\nWaugh I-PER\n, O\nRicky B-PER\nPonting I-PER\n, O\nGreg B-PER\nBlewett I-PER\n, O\nMichael B-PER\nBevan I-PER\n, O\nStuart B-PER\nLaw I-PER\n, O\nTom B-PER\nMoody I-PER\n, O\nIan B-PER\nHealy I-PER\n, O\nPaul B-PER\nReiffel I-PER\n, O\nShane B-PER\nWarne I-PER\n, O\nJason B-PER\nGillespie I-PER\n, O\nGlenn B-PER\nMcGrath I-PER\n12th O\nman O\n. O\n\nWest B-LOC\nIndies I-LOC\n- O\nSherwin B-PER\nCampbell I-PER\n, O\nRobert B-PER\nSamuels I-PER\n, O\nBrian B-PER\nLara I-PER\n, O\nShivnarine B-PER\nChanderpaul I-PER\n, O\nCarl B-PER\nHooper I-PER\n, O\nJimmy B-PER\nAdams I-PER\n, O\nJunior B-PER\nMurray I-PER\n, O\nNixon B-PER\nMcLean I-PER\n, O\nKenneth B-PER\nBenjamin I-PER\n, O\nCurtly B-PER\nAmbrose I-PER\n, O\nCourtney B-PER\nWalsh I-PER\n( O\ncaptain O\n) O\n, O\nRoland B-PER\nHolder I-PER\n12th O\nman O\n. O\n\n-DOCSTART- O\n\nBADMINTON O\n- O\nWORLD B-MISC\nGRAND I-MISC\nPRIX I-MISC\nRESULTS O\n. O\n\nBALI B-LOC\n1996-12-06 O\n\nResults O\nin O\nlast O\nof O\nthe O\ngroup O\nmatches O\nat O\nthe O\nWorld B-MISC\nGrand I-MISC\nPrix I-MISC\nbadminton O\nfinals O\non O\nFriday O\n: O\n\nMen O\n's O\nsingles O\n\nGroup O\nB O\n\nChen B-PER\nGang I-PER\n( O\nChina B-LOC\n) O\nbeat O\nMartin B-PER\nLondgaard I-PER\nHansen I-PER\n( O\nDenmark B-LOC\n) O\n15-12 O\n15-6 O\n\nDong B-PER\nJiong I-PER\n( O\nChina B-LOC\n) O\nbeat O\nThomas B-PER\nStuer-Lauridsen I-PER\n( O\nDenmark B-LOC\n) O\n15-10 O\n15-6 O\n\nIndra B-PER\nWijaya I-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\nOng B-PER\nEwe I-PER\nHock I-PER\n( O\nMalaysia B-LOC\n) O\n5-15 O\n15-11 O\n15-11 O\n\nGroup O\nC O\n\nSun B-PER\nJun I-PER\n( O\nChina B-LOC\n) O\nbeat O\nRashid B-PER\nSidek I-PER\n( O\nMalaysia B-LOC\n) O\n15-12 O\n17-14 O\n\nHermawan B-PER\nSusanto I-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\nSoren B-PER\nB. I-PER\nNielsen I-PER\n( O\nDenmark B-LOC\n) O\n15-8 O\n15-2 O\n\nGroup O\nD O\n\nAllan B-PER\nBudi I-PER\nKuksuma I-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\nPoul-Erik B-PER\nHoyer-Larsen I-PER\n( O\nDenmark B-LOC\n) O\n15-7 O\n15-4 O\n\nBudi B-PER\nSantoso I-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\nHu B-PER\nZhilan I-PER\n( O\nChina B-LOC\n) O\n15-4 O\n15-5 O\n\nSemifinals O\n( O\non O\nSaturday O\n) O\n: O\nFung B-PER\nPermadi I-PER\n( O\nTaiwan B-LOC\n) O\nv O\nIndra B-PER\n\nWijaya B-PER\n( O\nIndonesia B-LOC\n) O\n; O\nSun B-PER\nJun I-PER\n( O\nChina B-LOC\n) O\nv O\nAllan B-PER\nBudi I-PER\nKusuma I-PER\n\n( O\nIndonesia B-LOC\n) O\n\nWomen O\n's O\nsingles O\n\nGroup O\nA O\n\nGong B-PER\nZhichao I-PER\n( O\nChina B-LOC\n) O\nbeat O\nMia B-PER\nAudina I-PER\n( O\nIndonesia B-LOC\n) O\n11-2 O\n12-10 O\n\nGroup O\nB O\n\nYe B-PER\nZhaoying I-PER\n( O\nChina B-LOC\n) O\nbeat O\nMeiluawati B-PER\n( O\nIndonesia B-LOC\n) O\n11-6 O\n12-10 O\n\nGroup O\nC O\n\nCamilla B-PER\nMartin I-PER\n( O\nDenmark B-LOC\n) O\nbeat O\nWang B-PER\nChen I-PER\n( O\nChina B-LOC\n) O\n11-0 O\n12-10 O\n\nGroup O\nD O\n\nSusi B-PER\nSusanti I-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\nHan B-PER\nJingna I-PER\n( O\nChina B-LOC\n) O\n11-5 O\n11-4 O\n. O\n\nSemifinals O\n( O\non O\nSaturday O\n) O\n: O\nSusi B-PER\nSusanti I-PER\n( O\nIndonesia B-LOC\n) O\nv O\nCamilla B-PER\nMartin I-PER\n( O\nDenmark B-LOC\n) O\n; O\nYe B-PER\nZhaoying I-PER\n( O\nChina B-LOC\n) O\nv O\nGong B-PER\nZichao I-PER\n( O\nChina B-LOC\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nARAB B-MISC\nCONTRACTORS O\nWIN O\nAFRICAN B-MISC\nCUP I-MISC\nWINNERS I-MISC\n' I-MISC\nCUP I-MISC\n. O\n\nCAIRO B-LOC\n1996-12-06 O\n\nResult O\nof O\nthe O\nsecond O\nleg O\nof O\nthe O\nAfrican B-MISC\nCup I-MISC\nWinners I-MISC\n' I-MISC\nCup I-MISC\nfinal O\nat O\nthe O\nNational B-LOC\nstadium I-LOC\non O\nFriday O\n: O\nArab B-ORG\nContractors I-ORG\n( O\nEgypt B-LOC\n) O\n4 O\nSodigraf B-ORG\n( O\nZaire B-LOC\n) O\n0 O\n( O\nhalftime O\n2-0 O\n) O\n\nScorers O\n: O\n\nAly B-PER\nAshour I-PER\n7 O\n, O\n56 O\npenalty O\n, O\nMohamed B-PER\nOuda I-PER\n24 O\n, O\n73 O\n\nContractors O\nwon O\n4-0 O\non O\naggregate O\n. O\n\n-DOCSTART- O\n\nNHL B-ORG\nICE O\nHOCKEY O\n- O\nSTANDINGS O\nAFTER O\nTHURSDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nStandings O\nof O\nNational B-ORG\nHockey I-ORG\n\nLeague B-ORG\nteams O\nafter O\ngames O\nplayed O\non O\nThursday O\n( O\ntabulate O\nunder O\n\nwon O\n, O\nlost O\n, O\ntied O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nEASTERN O\nCONFERENCE O\n\nNORTHEAST O\nDIVISION O\n\nW O\nL O\nT O\nGF O\nGA O\nPTS O\n\nHARTFORD B-ORG\n12 O\n7 O\n6 O\n77 O\n76 O\n30 O\n\nBUFFALO B-ORG\n13 O\n12 O\n1 O\n77 O\n76 O\n27 O\n\nBOSTON B-ORG\n10 O\n11 O\n4 O\n74 O\n84 O\n24 O\n\nMONTREAL B-ORG\n10 O\n14 O\n4 O\n96 O\n103 O\n24 O\n\nPITTSBURGH B-ORG\n9 O\n13 O\n3 O\n81 O\n91 O\n21 O\n\nOTTAWA B-ORG\n7 O\n11 O\n6 O\n62 O\n72 O\n20 O\n\nATLANTIC B-LOC\nDIVISION O\n\nW O\nL O\nT O\nGF O\nGA O\nPTS O\n\nFLORIDA B-ORG\n17 O\n4 O\n6 O\n83 O\n53 O\n40 O\n\nPHILADELPHIA B-ORG\n14 O\n12 O\n2 O\n75 O\n75 O\n30 O\n\nNEW B-ORG\nJERSEY I-ORG\n14 O\n10 O\n1 O\n61 O\n61 O\n29 O\n\nWASHINGTON B-ORG\n13 O\n12 O\n1 O\n69 O\n66 O\n27 O\n\nNY B-ORG\nRANGERS I-ORG\n10 O\n13 O\n5 O\n91 O\n81 O\n25 O\n\nNY B-ORG\nISLANDERS I-ORG\n7 O\n11 O\n8 O\n65 O\n72 O\n22 O\n\nTAMPA B-ORG\nBAY I-ORG\n8 O\n15 O\n2 O\n69 O\n81 O\n18 O\n\nWESTERN O\nCONFERENCE O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nW O\nL O\nT O\nGF O\nGA O\nPTS O\n\nDETROIT B-ORG\n15 O\n9 O\n4 O\n81 O\n53 O\n34 O\n\nDALLAS B-ORG\n16 O\n9 O\n1 O\n74 O\n60 O\n33 O\n\nCHICAGO B-ORG\n12 O\n12 O\n3 O\n71 O\n67 O\n27 O\n\nST B-ORG\nLOUIS I-ORG\n13 O\n14 O\n0 O\n78 O\n81 O\n26 O\n\nTORONTO B-ORG\n11 O\n15 O\n0 O\n76 O\n89 O\n22 O\n\nPHOENIX B-ORG\n9 O\n13 O\n4 O\n61 O\n74 O\n22 O\n\nPACIFIC B-LOC\nDIVISION O\n\nW O\nL O\nT O\nGF O\nGA O\nPTS O\n\nCOLORADO B-ORG\n17 O\n6 O\n4 O\n97 O\n56 O\n38 O\n\nVANCOUVER B-ORG\n14 O\n11 O\n1 O\n84 O\n83 O\n29 O\n\nEDMONTON B-ORG\n13 O\n14 O\n1 O\n94 O\n88 O\n27 O\n\nLOS B-ORG\nANGELES I-ORG\n11 O\n13 O\n3 O\n72 O\n83 O\n25 O\n\nSAN B-ORG\nJOSE I-ORG\n10 O\n13 O\n4 O\n69 O\n87 O\n24 O\n\nCALGARY B-ORG\n10 O\n16 O\n2 O\n65 O\n77 O\n22 O\n\nANAHEIM B-ORG\n9 O\n14 O\n4 O\n73 O\n86 O\n22 O\n\nFRIDAY O\n, O\nDECEMBER O\n6 O\n\nANAHEIM B-ORG\nAT O\nBUFFALO B-LOC\n\nTORONTO B-ORG\nAT O\nNY B-ORG\nRANGERS I-ORG\n\nPITTSBURGH B-ORG\nAT O\nWASHINGTON B-LOC\n\nMONTREAL B-ORG\nAT O\nCHICAGO B-LOC\n\nPHILADELPHIA B-ORG\nAT O\nDALLAS B-LOC\n\nST B-ORG\nLOUIS I-ORG\nAT O\nCOLORADO B-LOC\n\nOTTAWA B-ORG\nAT O\nEDMONTON B-LOC\n\n-DOCSTART- O\n\nNHL B-ORG\nICE O\nHOCKEY O\n- O\nTHURSDAY O\n'S O\nRESULTS O\n. O\n\n[ O\nCORRECTED O\n08:40 O\nGMT B-MISC\n] O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\n( O\nCorrects O\nheadline O\nfrom O\nNBA B-ORG\nto O\nNHL B-ORG\nand O\ncorrects O\nteam O\nname O\nin O\nsecond O\nresult O\nfrom O\nLa B-ORG\nClippers I-ORG\nto O\nNy B-ORG\nIslanders I-ORG\n. O\n\n) O\n\nResults O\nof O\nNational B-ORG\nHockey I-ORG\n\nLeague B-ORG\ngames O\non O\nThursday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nHartford B-ORG\n4 O\nBOSTON B-ORG\n2 O\n\nFLORIDA B-ORG\n4 O\nNy B-ORG\nIslanders I-ORG\n2 O\n\nNEW B-ORG\nJERSEY I-ORG\n2 O\nCalgary B-ORG\n1 O\n\nPhoenix B-ORG\n3 O\nST B-ORG\nLOUIS I-ORG\n0 O\n\nTampa B-ORG\nBay I-ORG\n2 O\nLOS B-ORG\nANGELES I-ORG\n1 O\n\n-DOCSTART- O\n\nNFL B-ORG\nAMERICAN O\nFOOTBALL-COLTS O\nCLOBBER O\nEAGLES B-ORG\nTO O\nSTAY O\nIN O\nPLAYOFF O\nHUNT O\n. O\n\nINDIANAPOLIS B-LOC\n1996-12-06 O\n\nThe O\ninjury-plagued O\nIndianapolis B-ORG\nColts I-ORG\nlost O\nanother O\nquarterback O\non O\nThursday O\nbut O\nlast O\nyear O\n's O\nAFC O\nfinalists O\nrallied O\ntogether O\nto O\nshoot O\ndown O\nthe O\nPhiladelphia B-ORG\nEagles I-ORG\n37-10 O\nin O\na O\nshowdown O\nof O\nplayoff O\ncontenders O\n. O\n\nMarshall B-PER\nFaulk I-PER\nrushed O\nfor O\n101 O\nyards O\nand O\ntwo O\ntouchdowns O\nand O\nJason B-PER\nBelser I-PER\nreturned O\nan O\ninterception O\n44 O\nyards O\nfor O\na O\nscore O\nas O\nthe O\nColts B-ORG\nimproved O\nto O\n8-6 O\n, O\nthe O\nsame O\nmark O\nas O\nthe O\nEagles B-ORG\n, O\nwho O\nlost O\nfor O\nthe O\nfourth O\ntime O\nin O\nfive O\ngames O\n. O\n\nPaul B-PER\nJustin I-PER\n, O\nstarting O\nfor O\nthe O\nsidelined O\nJim B-PER\nHarbaugh I-PER\n, O\nwas O\n14-of-23 O\nfor O\n144 O\nyards O\nand O\na O\ntouchdown O\nfor O\nthe O\nthe O\nColts B-ORG\n, O\nwho O\nplayed O\ntheir O\nlast O\nhome O\ngame O\nof O\nthe O\nseason O\n. O\n\nIndianapolis B-LOC\ncloses O\nwith O\ngames O\nat O\nKansas B-LOC\nCity I-LOC\nand O\nCincinnati B-LOC\n. O\n\nThe O\nEagles B-ORG\nwere O\nheld O\nwithout O\na O\ntouchdown O\nuntil O\nthe O\nfinal O\nfive O\nseconds O\n. O\n\nPhiladelphia B-LOC\n, O\nwhich O\nfell O\nfrom O\nan O\nNFC O\nEast O\ntie O\nwith O\nthe O\nDallas B-ORG\nCowboys I-ORG\nand O\nWashington B-ORG\nRedskins I-ORG\n, O\ngo O\non O\nthe O\nroad O\nagainst O\nthe O\nNew B-ORG\nYork I-ORG\nJets I-ORG\nand O\nthen O\nentertain O\nArizona B-ORG\n. O\n\nThe O\nloss O\nby O\nPhiladelphia B-ORG\nallowed O\nthe O\nidle O\nGreen B-ORG\nBay I-ORG\nPackers I-ORG\n( O\n10-3 O\n) O\nto O\nclinch O\nthe O\nfirst O\nNFC O\nplayoff O\nberth O\n. O\n\nThe O\nColts B-ORG\nwon O\ndespite O\nthe O\nabsence O\nof O\ninjured O\nstarting O\ndefensive O\ntackle O\nTony B-PER\nSiragusa I-PER\n, O\ncornerback O\nRay B-PER\nBuchanan I-PER\nand O\nlinebacker O\nQuentin B-PER\nCoryatt I-PER\n. O\n\nFaulk B-PER\ncarried O\n16 O\ntimes O\n, O\nincluding O\na O\n13-yard O\nTD O\nrun O\nin O\nthe O\nfirst O\nquarter O\nand O\na O\nseven-yard O\nscore O\nearly O\nin O\nthe O\nfinal O\nperiod O\n. O\n\nJustin B-PER\nmade O\nhis O\nsecond O\nstraight O\nstart O\nfor O\nHarbaugh B-PER\n, O\nwho O\nhas O\na O\nknee O\ninjury O\n. O\n\nJustin B-PER\nsuffered O\na O\nsprained O\nright O\nshoulder O\nin O\nthe O\nthird O\nquarter O\nand O\ndid O\nnot O\nreturn O\n. O\n\nThird-stringer O\nKerwin B-PER\nBell I-PER\n, O\na O\n1988 O\ndraft O\nchoice O\nof O\nthe O\nMiami B-ORG\nDolphins I-ORG\n, O\nmade O\nhis O\nNFL B-ORG\ndebut O\nand O\nwas O\n5-of-5 O\nfor O\n75 O\nyards O\n, O\nincluding O\na O\n20-yard O\nscoring O\nstrike O\nto O\nMarvin B-PER\nHarrison I-PER\nin O\nthe O\nthird O\nperiod O\n. O\n\nA O\n39-yard O\ninterference O\npenalty O\nagainst O\nPhiladelphia B-LOC\n's O\nTroy B-PER\nVincent I-PER\nset O\nup O\nFaulk B-PER\n's O\nfirst O\nscore O\naround O\nleft O\nend O\nthat O\ncapped O\nan O\n80-yard O\nmarch O\n5:17 O\ninto O\nthe O\ngame O\nand O\nthe O\nrout O\nwas O\non O\n. O\n\nEagles B-ORG\nquarterback O\nTy B-PER\nDetmer I-PER\nwas O\n17-of-34 O\nfor O\n182 O\nyards O\nbefore O\nhe O\nwas O\nbenched O\n. O\n\nRicky B-PER\nWatters I-PER\n, O\nwho O\nleads O\nthe O\nNFC O\nin O\nrushing O\n, O\nleft O\nthe O\ngame O\nafter O\ngetting O\nkneed O\nto O\nthe O\nhelmet O\nafter O\ngaining O\n33 O\nyards O\non O\nseven O\ncarries O\n. O\n\n-DOCSTART- O\n\nNBA B-ORG\nBASKETBALL O\n- O\nSTANDINGS O\nAFTER O\nTHURSDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nStandings O\nof O\nNational B-ORG\n\nBasketball B-ORG\nAssociation I-ORG\nteams O\nafter O\ngames O\nplayed O\non O\nThursday O\n\n( O\ntabulate O\nunder O\nwon O\n, O\nlost O\n, O\npercentage O\n, O\ngames O\nbehind O\n) O\n: O\n\nEASTERN O\nCONFERENCE O\n\nATLANTIC B-LOC\nDIVISION O\n\nW O\nL O\nPCT O\nGB O\n\nMIAMI B-ORG\n14 O\n4 O\n.778 O\n- O\n\nNEW B-ORG\nYORK I-ORG\n10 O\n6 O\n.625 O\n3 O\n\nORLANDO B-ORG\n8 O\n6 O\n.571 O\n4 O\n\nWASHINGTON B-ORG\n7 O\n9 O\n.438 O\n6 O\n\nPHILADELPHIA B-ORG\n7 O\n10 O\n.412 O\n6 O\n1/2 O\n\nBOSTON B-ORG\n4 O\n12 O\n.250 O\n9 O\n\nNEW B-ORG\nJERSEY I-ORG\n3 O\n10 O\n.231 O\n8 O\n1/2 O\n\nCENTRAL O\nDIVISION O\n\nW O\nL O\nPCT O\nGB O\n\nCHICAGO B-ORG\n17 O\n1 O\n.944 O\n- O\n\nDETROIT B-ORG\n13 O\n3 O\n.813 O\n3 O\n\nCLEVELAND B-ORG\n11 O\n5 O\n.688 O\n5 O\n\nATLANTA B-ORG\n10 O\n8 O\n.556 O\n7 O\n\nCHARLOTTE B-ORG\n8 O\n8 O\n.500 O\n8 O\n\nMILWAUKEE B-ORG\n8 O\n8 O\n.500 O\n8 O\n\nINDIANA B-ORG\n7 O\n8 O\n.467 O\n8 O\n1/2 O\n\nTORONTO B-ORG\n6 O\n11 O\n.353 O\n10 O\n1/2 O\n\nWESTERN O\nCONFERENCE O\n\nMIDWEST O\nDIVISION O\n\nW O\nL O\nPCT O\nGB O\n\nHOUSTON B-ORG\n16 O\n2 O\n.889 O\n- O\n\nUTAH B-ORG\n14 O\n2 O\n.875 O\n1 O\n\nMINNESOTA B-ORG\n7 O\n10 O\n.412 O\n8 O\n1/2 O\n\nDALLAS B-ORG\n6 O\n11 O\n.353 O\n9 O\n1/2 O\n\nDENVER B-ORG\n5 O\n14 O\n.263 O\n11 O\n1/2 O\n\nSAN B-ORG\nANTONIO I-ORG\n3 O\n13 O\n.188 O\n12 O\n\nVANCOUVER B-ORG\n2 O\n16 O\n.111 O\n14 O\n\nPACIFIC B-LOC\nDIVISION O\n\nW O\nL O\nPCT O\nGB O\n\nSEATTLE B-ORG\n15 O\n5 O\n.750 O\n- O\n\nLA B-ORG\nLAKERS I-ORG\n13 O\n7 O\n.650 O\n2 O\n\nPORTLAND B-ORG\n11 O\n8 O\n.579 O\n3 O\n1/2 O\n\nLA B-ORG\nCLIPPERS I-ORG\n7 O\n11 O\n.389 O\n7 O\n\nGOLDEN B-ORG\nSTATE I-ORG\n6 O\n12 O\n.333 O\n8 O\n\nSACRAMENTO B-ORG\n6 O\n12 O\n.333 O\n8 O\n\nPHOENIX B-ORG\n2 O\n14 O\n.125 O\n11 O\n\nFRIDAY O\n, O\nDECEMBER O\n6 O\n\nNEW B-ORG\nJERSEY I-ORG\nAT O\nBOSTON B-LOC\n\nCLEVELAND B-ORG\nAT O\nDETROIT B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nMIAMI B-LOC\n\nPHOENIX B-ORG\nAT O\nSACRAMENTO B-LOC\n\nVANCOUVER B-ORG\nAT O\nSAN B-LOC\nANTONIO I-LOC\n\nMINNESOTA B-ORG\nAT O\nUTAH B-LOC\n\nCHARLOTTE B-ORG\nAT O\nPORTLAND B-LOC\n\nINDIANA B-ORG\nAT O\nGOLDEN B-LOC\nSTATE I-LOC\n\nORLANDO B-ORG\nAT O\nLA B-LOC\nLAKERS I-LOC\n\n-DOCSTART- O\n\nNFL B-ORG\nAMERICAN O\nFOOTBALL-STANDINGS O\nAFTER O\nTHURSDAY O\n'S O\nGAME O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-05 O\n\nNational B-ORG\nFootball I-ORG\nLeague I-ORG\n\nstandings O\nafter O\nThursday O\n's O\ngame O\n( O\ntabulate O\nunder O\nwon O\n, O\nlost O\n, O\n\ntied O\n, O\npoints O\nfor O\nand O\npoints O\nagainst O\n) O\n: O\n\nAMERICAN B-MISC\nFOOTBALL O\nCONFERENCE O\n\nEASTERN O\nDIVISION O\n\nW O\nL O\nT O\nPF O\nPA O\n\nNEW B-ORG\nENGLAND I-ORG\n9 O\n4 O\n0 O\n355 O\n269 O\n\nBUFFALO B-ORG\n9 O\n4 O\n0 O\n267 O\n215 O\n\nINDIANAPOLIS B-ORG\n8 O\n6 O\n0 O\n269 O\n284 O\n\nMIAMI B-ORG\n6 O\n7 O\n0 O\n285 O\n266 O\n\nNY B-ORG\nJETS I-ORG\n1 O\n12 O\n0 O\n221 O\n368 O\n\nCENTRAL O\nDIVISION O\n\nW O\nL O\nT O\nPF O\nPA B-ORG\n\nPITTSBURGH B-ORG\n9 O\n4 O\n0 O\n299 O\n211 O\n\nHOUSTON B-ORG\n7 O\n6 O\n0 O\n291 O\n254 O\n\nJACKSONVILLE B-ORG\n6 O\n7 O\n0 O\n263 O\n288 O\n\nCINCINNATI B-ORG\n5 O\n8 O\n0 O\n299 O\n318 O\n\nBALTIMORE B-ORG\n4 O\n9 O\n0 O\n320 O\n369 O\n\nWESTERN O\nDIVISION O\n\nW O\nL O\nT O\nPF O\nPA O\n\nX-DENVER B-MISC\n12 O\n1 O\n0 O\n351 O\n199 O\n\nKANSAS B-ORG\nCITY I-ORG\n9 O\n4 O\n0 O\n262 O\n230 O\n\nSAN B-ORG\nDIEGO I-ORG\n7 O\n6 O\n0 O\n277 O\n323 O\n\nOAKLAND B-ORG\n6 O\n7 O\n0 O\n274 O\n234 O\n\nSEATTLE B-ORG\n5 O\n8 O\n0 O\n250 O\n317 O\n\nNATIONAL O\nFOOTBALL O\nCONFERENCE O\n\nEASTERN O\nDIVISION O\n\nW O\nL O\nT O\nPF O\nPA O\n\nDALLAS B-ORG\n8 O\n5 O\n0 O\n254 O\n201 O\n\nWASHINGTON B-ORG\n8 O\n5 O\n0 O\n291 O\n251 O\n\nPHILADELPHIA B-ORG\n8 O\n6 O\n0 O\n313 O\n302 O\n\nARIZONA B-ORG\n6 O\n7 O\n0 O\n248 O\n332 O\n\nNY B-ORG\nGIANTS I-ORG\n5 O\n8 O\n0 O\n200 O\n250 O\n\nCENTRAL O\nDIVISION O\n\nW O\nL O\nT O\nPF O\nPA O\n\nY-GREEN B-MISC\nBAY I-MISC\n10 O\n3 O\n0 O\n346 O\n191 O\n\nMINNESOTA B-ORG\n7 O\n6 O\n0 O\n243 O\n245 O\n\nCHICAGO B-ORG\n5 O\n8 O\n0 O\n202 O\n248 O\n\nDETROIT B-ORG\n5 O\n8 O\n0 O\n263 O\n289 O\n\nTAMPA B-ORG\nBAY I-ORG\n4 O\n9 O\n0 O\n153 O\n243 O\n\nWESTERN O\nDIVISION O\n\nW O\nL O\nT O\nPF O\nPA O\n\nSAN B-ORG\nFRANCISCO I-ORG\n10 O\n3 O\n0 O\n325 O\n198 O\n\nCAROLINA B-ORG\n9 O\n4 O\n0 O\n292 O\n164 O\n\nST B-ORG\nLOUIS I-ORG\n4 O\n9 O\n0 O\n246 O\n334 O\n\nATLANTA B-ORG\n2 O\n11 O\n0 O\n234 O\n393 O\n\nNEW B-ORG\nORLEANS I-ORG\n2 O\n11 O\n0 O\n184 O\n291 O\n\nX O\n-- O\nCLINCHED O\nDIVISION O\nTITLE O\n\nY O\n-- O\nCLINCHED O\nPLAYOFF O\nBERTH O\n\nSUNDAY O\n, O\nDECEMBER O\n8 O\n\nST B-ORG\nLOUIS I-ORG\nAT O\nCHICAGO B-LOC\n\nBALTIMORE B-ORG\nAT O\nCINCINNATI B-LOC\n\nDENVER B-ORG\nAT O\nGREEN B-LOC\nBAY I-LOC\n\nJACKSONVILLE B-ORG\nAT O\nHOUSTON B-LOC\n\nNY B-ORG\nGIANTS I-ORG\nAT O\nMIAMI B-LOC\n\nATLANTA B-ORG\nAT O\nNEW B-LOC\nORLEANS I-LOC\n\nSAN B-ORG\nDIEGO I-ORG\nAT O\nPITTSBURGH B-LOC\n\nWASHINGTON B-ORG\nAT O\nTAMPA B-LOC\nBAY I-LOC\n\nDALLAS B-ORG\nAT O\nARIZONA B-LOC\n\nNY B-ORG\nJETS I-ORG\nAT O\nNEW B-LOC\nENGLAND I-LOC\n\nBUFFALO B-ORG\nAT O\nSEATTLE B-LOC\n\nCAROLINA B-ORG\nAT O\nSAN B-LOC\nFRANCISCO I-LOC\n\nMINNESOTA B-ORG\nAT O\nDETROIT B-LOC\n\nMONDAY O\n, O\nDECEMBER O\n9 O\n\nKANSAS B-ORG\nCITY I-ORG\nAT O\nOAKLAND B-LOC\n\n-DOCSTART- O\n\nNFL B-ORG\nAMERICAN O\nFOOTBALL-THURSDAY O\n'S O\nRESULT O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-05 O\n\nResult O\nof O\nNational B-ORG\nFootball B-LOC\n\nLeague B-LOC\ngame O\non O\nThursday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nINDIANAPOLIS B-ORG\n37 O\nPhiladelphia B-ORG\n10 O\n\n-DOCSTART- O\n\nNCAA B-ORG\nAMERICAN O\nFOOTBALL-OHIO B-MISC\nSTATE I-MISC\n'S O\nPACE B-PER\nFIRST O\nREPEAT O\nLOMBARDI B-MISC\nAWARD I-MISC\nWINNER O\n. O\n\nHOUSTON B-LOC\n1996-12-05 O\n\nOhio B-ORG\nState I-ORG\nleft O\ntackle O\nOrlando B-PER\nPace I-PER\nbecame O\nthe O\nfirst O\nrepeat O\nwinner O\nof O\nthe O\nLombardi B-MISC\nAward I-MISC\nThursday O\nnight O\nwhen O\nthe O\nRotary B-ORG\nClub I-ORG\nof O\nHouston B-LOC\nagain O\nhonoured O\nhim O\nas O\ncollege O\nfootball O\n's O\nlineman O\nof O\nthe O\nyear O\n. O\n\nPace B-PER\n, O\na O\njunior O\n, O\nhelped O\nOhio B-ORG\nState I-ORG\nto O\na O\n10-1 O\nrecord O\nand O\na O\nberth O\nin O\nthe O\nRose B-MISC\nBowl I-MISC\nagainst O\nArizona B-ORG\nState I-ORG\n. O\n\nHe O\nwas O\nthe O\nmost O\ndominant O\noffensive O\nlineman O\nin O\nthe O\ncountry O\nand O\nalso O\nplayed O\ndefensive O\nline O\nin O\ngoal-line O\nsituations O\n. O\n\nLast O\nyear O\n, O\nPace B-PER\nbecame O\nthe O\nfirst O\nsophomore O\nto O\nwin O\nthe O\naward O\nsince O\nits O\ninception O\nin O\n1970 O\n. O\n\nPace B-PER\noutdistanced O\nthree O\nsenior O\nfinalists O\n-- O\nVirginia B-ORG\nTech I-ORG\ndefensive O\nend O\nCornell B-PER\nBrown I-PER\n, O\nArizona B-ORG\nState I-ORG\noffensive O\ntackle O\nJuan B-PER\nRoque I-PER\nand O\ndefensive O\nend O\nJared B-PER\nTomich I-PER\nof O\nNebraska B-ORG\n. O\n\nThe O\nLombardi B-MISC\nAward I-MISC\nis O\npresented O\nto O\nthe O\ncollege O\nlineman O\nwho O\n, O\nin O\naddition O\nto O\noutstanding O\neffort O\non O\nthe O\nfield O\n, O\nbest O\nexemplifies O\nthe O\ncharacteristics O\nand O\ndiscipline O\nof O\nVince B-PER\nLombardi I-PER\n, O\nlegendary O\ncoach O\nof O\nthe O\nGreen B-ORG\nBay I-ORG\nPackers I-ORG\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nAMSTERDAM B-LOC\n1996-12-06 O\n\nResult O\nof O\nDutch B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatch O\nplayed O\non O\nFriday O\n: O\n\nRKC B-ORG\nWaalwijk I-ORG\n1 O\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n2 O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nPSV B-ORG\nEindhoven I-ORG\n18 O\n13 O\n3 O\n2 O\n52 O\n14 O\n42 O\n\nFeyenoord B-ORG\n17 O\n11 O\n3 O\n3 O\n29 O\n20 O\n36 O\n\nTwente B-ORG\nEnschede I-ORG\n18 O\n10 O\n4 O\n4 O\n28 O\n15 O\n34 O\n\nGraafschap B-ORG\nDoetinchem I-ORG\n18 O\n9 O\n3 O\n6 O\n29 O\n22 O\n30 O\n\nVitesse B-ORG\nArnhem I-ORG\n18 O\n8 O\n5 O\n5 O\n29 O\n21 O\n29 O\n\nAjax B-ORG\nAmsterdam I-ORG\n18 O\n7 O\n8 O\n3 O\n23 O\n16 O\n29 O\n\nHeerenveen B-ORG\n18 O\n7 O\n7 O\n4 O\n30 O\n20 O\n28 O\n\nRoda B-ORG\nJC I-ORG\nKerkrade I-ORG\n17 O\n7 O\n6 O\n4 O\n19 O\n21 O\n27 O\n\nUtrecht B-ORG\n18 O\n4 O\n10 O\n4 O\n26 O\n24 O\n22 O\n\nVolendam B-ORG\n18 O\n5 O\n6 O\n7 O\n20 O\n23 O\n21 O\n\nSparta B-ORG\nRotterdam I-ORG\n19 O\n6 O\n3 O\n10 O\n21 O\n25 O\n21 O\n\nNAC B-ORG\nBreda I-ORG\n18 O\n6 O\n3 O\n9 O\n17 O\n29 O\n21 O\n\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n18 O\n5 O\n4 O\n9 O\n19 O\n31 O\n19 O\n\nGroningen B-ORG\n18 O\n4 O\n6 O\n8 O\n20 O\n31 O\n18 O\n\nAZ B-ORG\nAlkmaar I-ORG\n18 O\n5 O\n2 O\n11 O\n16 O\n23 O\n17 O\n\nFortuna B-ORG\nSittard I-ORG\n17 O\n3 O\n7 O\n7 O\n14 O\n28 O\n16 O\n\nNEC B-ORG\nNijmegen I-ORG\n18 O\n3 O\n7 O\n8 O\n19 O\n32 O\n16 O\n\nRKC B-ORG\nWaalwijk I-ORG\n19 O\n3 O\n5 O\n11 O\n18 O\n33 O\n14 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nBONN B-LOC\n1996-12-06 O\n\nResults O\nof O\nGerman B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatches O\nplayed O\non O\nFriday O\n: O\n\nBochum B-ORG\n2 O\nBayer B-ORG\nLeverkusen I-ORG\n2 O\n\nWerder B-ORG\nBremen I-ORG\n1 O\n1860 B-ORG\nMunich I-ORG\n1 O\n\nKarlsruhe B-ORG\n3 O\nFreiburg B-ORG\n0 O\n\nSchalke B-ORG\n2 O\nHansa B-ORG\nRostock I-ORG\n0 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\ngoals O\nagainst O\npoints O\n) O\n: O\n\nBayer B-ORG\nLeverkusen I-ORG\n17 O\n10 O\n4 O\n3 O\n38 O\n22 O\n34 O\n\nBayern B-ORG\nMunich I-ORG\n16 O\n9 O\n6 O\n1 O\n26 O\n14 O\n33 O\n\nVfB B-ORG\nStuttgart I-ORG\n16 O\n9 O\n4 O\n3 O\n39 O\n17 O\n31 O\n\nBorussia B-ORG\nDortmund I-ORG\n16 O\n9 O\n4 O\n3 O\n33 O\n17 O\n31 O\n\nKarlsruhe B-ORG\n17 O\n8 O\n4 O\n5 O\n30 O\n20 O\n28 O\n\nVfL B-ORG\nBochum I-ORG\n16 O\n7 O\n6 O\n3 O\n23 O\n21 O\n27 O\n\n1. B-ORG\nFC I-ORG\nCologne I-ORG\n16 O\n8 O\n2 O\n6 O\n31 O\n27 O\n26 O\n\nSchalke B-ORG\n04 I-ORG\n17 O\n7 O\n4 O\n6 O\n25 O\n26 O\n25 O\n\nWerder B-ORG\nBremen I-ORG\n17 O\n6 O\n4 O\n7 O\n29 O\n28 O\n22 O\n\nMSV B-ORG\nDuisburg I-ORG\n16 O\n5 O\n4 O\n7 O\n16 O\n22 O\n19 O\n\nSV B-ORG\n1860 I-ORG\nMunich I-ORG\n17 O\n4 O\n6 O\n7 O\n25 O\n31 O\n18 O\n\nFC B-ORG\nSt. I-ORG\nPauli I-ORG\n15 O\n5 O\n3 O\n7 O\n21 O\n28 O\n18 O\n\nFortuna B-ORG\nDusseldorf I-ORG\n16 O\n5 O\n3 O\n8 O\n13 O\n24 O\n18 O\n\nHamburger B-ORG\nSV I-ORG\n16 O\n4 O\n5 O\n7 O\n20 O\n25 O\n17 O\n\nArminia B-ORG\nBielefeld I-ORG\n16 O\n4 O\n4 O\n8 O\n18 O\n28 O\n16 O\n\nFC B-ORG\nHansa I-ORG\nRostock I-ORG\n17 O\n4 O\n3 O\n10 O\n19 O\n26 O\n15 O\n\nBorussia B-ORG\nMonchengladbach I-ORG\n16 O\n4 O\n3 O\n9 O\n12 O\n22 O\n15 O\n\nSC B-ORG\nFreiburg I-ORG\n17 O\n4 O\n1 O\n12 O\n20 O\n40 O\n13 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nSUMMARIES O\n. O\n\nPARIS B-LOC\n1996-12-06 O\n\nSummaries O\nof O\nFrench B-MISC\nfirst O\ndivision O\n\nmatches O\non O\nFriday O\n: O\n\nLens B-ORG\n0 O\nNantes B-ORG\n4 O\n( O\nJaphet B-PER\nN'Doram I-PER\n7 O\n, O\nClaude B-PER\nMakelele I-PER\n42 O\n, O\nJocelyn B-PER\n\nGourvennec B-PER\n67 O\n, O\nChristophe B-PER\nPignol I-PER\n72 O\n) O\n. O\n\nHalftime O\n0-2 O\n. O\n\nAttendance O\n: O\n\n15,000 O\n. O\n\nParis B-ORG\nSt I-ORG\nGermain I-ORG\n1 O\n( O\nBruno B-PER\nN'Gotty I-PER\n2 O\n) O\nNancy B-ORG\n2 O\n( O\nPaul B-PER\nFischer I-PER\n\n70 O\n, O\nPhil B-PER\nGray I-PER\n89 O\n) O\n. O\n\n1-0 O\n. O\n\n30,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nSUMMARIES O\n. O\n\nAMSTERDAM B-LOC\n1996-12-06 O\n\nSummary O\nof O\nDutch B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatch O\nplayed O\non O\nFriday O\n: O\n\nRKC B-ORG\nWaalwijk I-ORG\n1 O\n( O\nStarbuck O\n76 O\n) O\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n2 O\n( O\nKonterman B-PER\n45 O\n, O\n\nVan B-PER\nder I-PER\nVegt I-PER\n77 O\n) O\n. O\n\nHalftime O\n0-1 O\n. O\n\nAttendance O\n5,300 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nSTANDINGS O\n. O\n\nPARIS B-LOC\n1996-12-06 O\n\nStandings O\nin O\nthe O\nFrench B-MISC\nfirst O\n\ndivision O\nafter O\nFriday O\n's O\nmatches O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\n\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nParis B-ORG\nSaint-Germain I-ORG\n21 O\n12 O\n6 O\n3 O\n34 O\n15 O\n42 O\n\nMonaco B-ORG\n20 O\n12 O\n5 O\n3 O\n36 O\n16 O\n41 O\n\nBordeaux B-ORG\n20 O\n9 O\n7 O\n4 O\n29 O\n21 O\n34 O\n\nStrasbourg B-ORG\n20 O\n11 O\n1 O\n8 O\n27 O\n27 O\n34 O\n\nBastia B-ORG\n20 O\n9 O\n6 O\n5 O\n27 O\n22 O\n33 O\n\nAuxerre B-ORG\n20 O\n8 O\n8 O\n4 O\n26 O\n12 O\n32 O\n\nMetz B-ORG\n20 O\n8 O\n7 O\n5 O\n21 O\n16 O\n31 O\n\nNantes B-ORG\n21 O\n7 O\n9 O\n5 O\n41 O\n25 O\n30 O\n\nGuingamp B-ORG\n20 O\n7 O\n7 O\n6 O\n18 O\n18 O\n28 O\n\nLille B-ORG\n20 O\n7 O\n7 O\n6 O\n22 O\n28 O\n28 O\n\nMarseille B-ORG\n20 O\n6 O\n8 O\n6 O\n18 O\n17 O\n26 O\n\nLyon B-ORG\n20 O\n6 O\n8 O\n6 O\n24 O\n31 O\n26 O\n\nRennes B-ORG\n20 O\n7 O\n4 O\n9 O\n23 O\n28 O\n25 O\n\nLens B-ORG\n21 O\n7 O\n4 O\n10 O\n25 O\n34 O\n25 O\n\nLe B-ORG\nHavre I-ORG\n20 O\n5 O\n7 O\n8 O\n20 O\n21 O\n22 O\n\nCannes B-ORG\n20 O\n5 O\n7 O\n8 O\n13 O\n22 O\n22 O\n\nMontpellier B-ORG\n20 O\n3 O\n9 O\n8 O\n17 O\n24 O\n18 O\n\nCaen B-ORG\n20 O\n3 O\n7 O\n10 O\n12 O\n23 O\n16 O\n\nNancy B-ORG\n21 O\n3 O\n7 O\n11 O\n14 O\n26 O\n16 O\n\nNice B-ORG\n20 O\n3 O\n4 O\n13 O\n17 O\n38 O\n13 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nRESULTS O\n. O\n\nPARIS B-LOC\n1996-12-06 O\n\nResults O\nof O\nFrench B-MISC\nfirst O\ndivision O\n\nmatches O\non O\nFriday O\n: O\n\nLens B-ORG\n0 O\nNantes B-ORG\n4 O\n\nParis B-ORG\nSt I-ORG\nGermain I-ORG\n1 O\nNancy B-ORG\n2 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nSUMMARIES O\n. O\n\nBONN B-LOC\n1996-12-06 O\n\nSummaries O\nof O\nmatches O\nplayed O\nin O\nthe O\nGerman B-MISC\nfirst O\ndivision O\non O\nFriday O\n: O\n\nBochum B-ORG\n2 O\n( O\nStickroth B-PER\n30th O\npen O\n, O\nWosz B-PER\n89th O\n) O\nBayer B-ORG\nLeverkusen I-ORG\n2 O\n( O\nKirsten B-PER\n18th O\n, O\nRamelow B-PER\n56th O\n) O\n. O\n\nHalftime O\n1-1 O\n. O\n\nAttendance O\n: O\n24,602 O\n\nWerder B-ORG\nBremen I-ORG\n1 O\n( O\nBode B-PER\n85th O\n) O\n1860 B-ORG\nMunich I-ORG\n1 O\n( O\nBormirow B-PER\n8th O\n) O\n. O\n\nHalftime O\n0-1 O\n. O\n\nAttendance O\n33,000 O\n\nKarlsruhe B-LOC\n3 O\n( O\nReich B-PER\n29th O\n, O\nCarl B-PER\n44th O\n, O\nDundee B-ORG\n69th O\n) O\nFreiburg B-LOC\n0 O\n. O\n\nHalftime O\n2-0 O\n. O\n\nAttendance O\n33,000 O\n\nSchalke B-ORG\n2 O\n( O\nMulder B-PER\n2nd O\nand O\n27th O\n) O\nHansa B-ORG\nRostock I-ORG\n0 O\n. O\n\nHalftime O\n2-0 O\n. O\n\nAttendance O\n29,300 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nGRAND B-MISC\nSLAM I-MISC\nCUP I-MISC\nQUARTER-FINAL O\nRESULTS O\n. O\n\nMUNICH B-LOC\n, O\nGermany B-LOC\n1996-12-06 O\n\nQuarter-final O\nresults O\nat O\nthe O\n$ O\n6 O\nmillion O\nGrand B-MISC\nSlam I-MISC\nCup I-MISC\ntennis O\ntournament O\non O\nFriday O\n: O\nGoran B-PER\nIvanisevic I-PER\n( O\nCroatia B-LOC\n) O\nbeat O\nMark B-PER\nWoodforde I-PER\n( O\nAustralia B-LOC\n) O\n6-4 O\n6-4 O\n\nYevgeny B-PER\nKafelnikov I-PER\n( O\nRussia B-LOC\n) O\nbeat O\nJim B-PER\nCourier I-PER\n( O\nU.S. B-LOC\n) O\n2-6 O\n6-4 O\n8-6 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nWEAH B-PER\nHEAD-BUTT O\nDEPRIVES O\nPORTUGAL B-LOC\nOF O\nCOSTA B-PER\n. O\n\nLISBON B-LOC\n1996-12-06 O\n\nPortugal B-LOC\ncalled O\nup O\nPorto B-ORG\ncentral O\ndefender O\nJoao B-PER\nManuel I-PER\nPinto I-PER\non O\nFriday O\nto O\nface O\nGermany B-LOC\nin O\na O\nWorld B-MISC\nCup I-MISC\nqualifier O\nin O\nplace O\nof O\ninjured O\nclub O\ncolleague O\nJorge B-PER\nCosta I-PER\n, O\nwho O\nis O\nstill O\nnursing O\na O\nbroken O\nnose O\nafter O\nbeing O\nhead-butted O\nby O\nLiberian B-MISC\nstriker O\nGeorg B-PER\nWeah I-PER\n. O\n\nCosta B-PER\nhas O\nnot O\nplayed O\nsince O\nbeing O\nstruck O\nby O\nthe O\nAC B-ORG\nMilan I-ORG\nforward O\nafter O\na O\nbad-tempered O\nEuropean B-MISC\nChampions I-MISC\n' I-MISC\nLeague I-MISC\ngame O\non O\nNovember O\n27 O\n. O\n\nPortugal B-LOC\nlead O\nEuropean B-MISC\nqualifying O\ngroup O\nnine O\nwith O\nseven O\npoints O\nfrom O\nfour O\ngames O\n, O\none O\nmore O\nthan O\nUkraine B-LOC\nand O\nthree O\nmore O\nthan O\nGermany B-LOC\n, O\nwho O\nhave O\nonly O\nplayed O\ntwice O\n. O\n\nThe O\nPortuguese B-MISC\nhost O\nGermany B-LOC\non O\nDecember O\n14 O\n. O\n\nSquad O\n: O\n\nGoalkeepers O\n- O\nVitor B-PER\nBaia I-PER\n( O\nBarcelona B-ORG\n, O\nSpain B-LOC\n) O\n, O\nRui B-PER\nCorreia I-PER\n( O\nBraga B-ORG\n) O\n: O\n\nDefenders O\n- O\nPaulinho B-PER\nSantos I-PER\n( O\nPorto B-ORG\n) O\n, O\nSergio B-PER\nConceicao I-PER\n( O\nPorto B-ORG\n) O\n, O\nJoao B-PER\nManuel I-PER\nPinto I-PER\n( O\nPorto B-ORG\n) O\n, O\nOceano B-PER\nCruz I-PER\n( O\nSporting B-ORG\n) O\n, O\nFernando B-PER\nCouto I-PER\n( O\nBarcelona B-ORG\n) O\n, O\nHelder B-PER\nCristovao I-PER\n( O\nDeportivo B-ORG\nCoruna I-ORG\n, O\nSpain B-LOC\n) O\n, O\nDimas B-PER\nTeixeira I-PER\n( O\nJuventus B-ORG\n, O\nItaly B-LOC\n) O\n, O\nCarlos B-PER\nSecretario I-PER\n( O\nReal B-ORG\nMadrid I-ORG\n, O\nSpain B-LOC\n) O\n: O\n\nMidfielders O\n- O\nRui B-PER\nBarros I-PER\n( O\nPorto B-ORG\n) O\n, O\nJose B-PER\nBarroso I-PER\n( O\nPorto B-ORG\n) O\n, O\nLuis B-PER\nFigo I-PER\n( O\nBarcelona B-ORG\n) O\n, O\nPaulo B-PER\nBento I-PER\n( O\nOviedo B-ORG\n, O\nSpain B-LOC\n) O\n, O\nJose B-PER\nTaira I-PER\n( O\nSalamanca B-ORG\n, O\nSpain B-LOC\n) O\n: O\n\nForwards O\n- O\nAntonio B-PER\nFolha I-PER\n( O\nPorto B-ORG\n) O\n, O\nJoao B-PER\nVieira I-PER\nPinto I-PER\n( O\nBenfica B-ORG\n) O\n, O\nPaulo B-PER\nAlves I-PER\n( O\nSporting B-ORG\n) O\n, O\nRui B-PER\nCosta I-PER\n( O\nFiorentina B-ORG\n, O\nItaly B-LOC\n) O\n, O\nJorge B-PER\nCadete I-PER\n( O\nCeltic B-ORG\nGlasgow I-ORG\n, O\nScotland B-LOC\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\nSHOWCASE-BETTING O\nON O\nREAL B-ORG\nMADRID I-ORG\nV O\nBARCELONA B-ORG\n. O\n\nMADRID B-LOC\n1996-12-06 O\n\nWilliam B-PER\nHill I-PER\nbetting O\non O\nSaturday O\n's O\n\nSpanish B-MISC\nfirst O\ndivision O\nmatch O\nbetween O\nReal B-ORG\nMadrid I-ORG\nand O\nBarcelona B-ORG\n: O\n\nTo O\nwin O\n: O\n6-5 O\nReal B-ORG\nMadrid I-ORG\n; O\n7-4 O\nBarcelona B-ORG\n\nDraw O\n: O\n9-4 O\n\nCorrect O\nscore O\n: O\n\nReal B-ORG\nMadrid I-ORG\nto O\nwin O\nBarcelona B-ORG\nto O\nwin O\n\n1-0 O\n13-2 O\n1-0 O\n15-2 O\n\n2-0 O\n9-1 O\n2-0 O\n12-1 O\n\n2-1 O\n8-1 O\n2-1 O\n10-1 O\n\n3-0 O\n20-1 O\n3-0 O\n28-1 O\n\n3-1 O\n16-1 O\n3-1 O\n22-1 O\n\n3-2 O\n25-1 O\n3-2 O\n25-1 O\n\n4-0 O\n50-1 O\n4-0 O\n100-1 O\n\n4-1 O\n40-1 O\n4-1 O\n80-1 O\n\n4-2 O\n50-1 O\n4-2 O\n80-1 O\n\nDraw O\n: O\n\n0-0 O\n8-1 O\n\n1-1 O\n11-2 O\n\n2-2 O\n14-1 O\n\n3-3 O\n50-1 O\n\nDouble O\nresult O\n: O\n\nhalf-time O\nfull-time O\n\n5-2 O\nReal B-ORG\nMadrid I-ORG\nReal B-ORG\nMadrid I-ORG\n\n14-1 O\nReal B-ORG\nMadrid I-ORG\nDraw O\n\n28-1 O\nReal B-ORG\nMadrid I-ORG\nBarcelona B-ORG\n\n5-1 O\nDraw O\nReal B-ORG\nMadrid I-ORG\n\n4-1 O\nDraw O\nDraw O\n\n11-2 O\nDraw O\nBarcelona B-ORG\n\n25-1 O\nBarcelona B-ORG\nReal B-ORG\nMadrid I-ORG\n\n14-1 O\nBarcelona B-ORG\nDraw O\n\n4-1 O\nBarcelona B-ORG\nBarcelona B-ORG\n\nFirst O\ngoalscorer O\nof O\nmatch O\n: O\n\nReal B-ORG\nMadrid I-ORG\nBarcelona B-ORG\n\n9-2 O\nDavor B-PER\nSuker I-PER\n9-2 O\nRonaldo B-PER\n\n5-1 O\nPedrag B-PER\nMijatovic I-PER\n7-1 O\nLuis B-PER\nFigo I-PER\n\n7-1 O\nRaul B-PER\nGonzalez I-PER\n7-1 O\nJuan B-PER\nPizzi I-PER\n\n12-1 O\nFernando B-PER\nRedondo I-PER\n9-1 O\nGiovanni B-PER\n\n14-1 O\nVictor B-PER\nSanchez I-PER\n12-1 O\nGuillermo B-PER\n\nAmor B-PER\n\n16-1 O\nJose B-PER\nAmavisca I-PER\n14-1 O\nRoger B-PER\nGarcia I-PER\n\n16-1 O\nManolo B-PER\nSanchis I-PER\n14-1 O\nGheorghe B-PER\n\nPopescu B-PER\n\n16-1 O\nRoberto B-PER\nCarlos I-PER\n16-1 O\n\nJosepGuardiola B-PER\n\n20-1 O\nFernando B-PER\nHierro I-PER\n20-1 O\nIvan B-PER\nde I-PER\n\nlaPena B-PER\n\n20-1 O\nLuis B-PER\nMilla I-PER\n25-1 O\nLuis B-PER\n\nEnrique B-PER\n\n33-1 O\nFernando B-PER\nSanz I-PER\n25-1 O\n\nAbelardoFernandez B-PER\n\n40-1 O\nCarlos B-PER\nSecretario I-PER\n28-1 O\nSergi B-PER\nBarjuan I-PER\n\n40-1 O\nRafael B-PER\nAlkorta I-PER\n33-1 O\nAlbert B-PER\n\nFerrer B-PER\n\n40-1 O\nChendo B-PER\nPorlan I-PER\n33-1 O\nMiguel B-PER\nNadal I-PER\n\n40-1 O\n\nLaurent B-PER\nBlanc I-PER\n\n-DOCSTART- O\n\nSOCCER O\nSHOWCASE-FANS O\nFACE O\nBREATHALYSER O\nTESTS O\n, O\nPAPER O\nSAYS O\n. O\n\nMADRID B-LOC\n1996-12-06 O\n\nSpanish B-MISC\npolice O\nwill O\nbreathalyse O\nfans O\nat O\nthe O\ngates O\nof O\nthe O\nSantiago B-LOC\nBernabeu I-LOC\nstadium I-LOC\nand O\nban O\ndrunk O\nsupporters O\nfrom O\nSaturday O\n's O\nbig O\nReal B-MISC\nMadrid-Barcelona I-MISC\ngame O\n, O\nthe O\nMadrid B-LOC\ndaily O\nEl B-ORG\nMundo I-ORG\nsaid O\non O\nFriday O\n. O\n\nAlthough O\nthere O\nare O\nno O\nknown O\nprecedents O\nin O\nthe O\ncountry O\n, O\nthe O\naction O\nis O\nenvisaged O\nin O\nSpanish B-MISC\nlegislation O\ngoverning O\nsports O\nevents O\n. O\n\nTickets O\nfor O\nthe O\ngame O\nstipulate O\nthat O\nsupporters O\nwill O\nbe O\nbarred O\nif O\nthey O\nare O\n\" O\nunder O\nthe O\neffects O\nof O\nalcohol O\n\" O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSPANISH B-MISC\nFIRST O\nDIVISION O\nSTANDINGS O\n. O\n\nMADRID B-LOC\n1996-12-06 O\n\nStandings O\nin O\nthe O\nSpanish B-MISC\nfirst O\n\ndivision O\nahead O\nof O\nthis O\nweekend O\n's O\ngames O\n. O\n\n( O\ntabulate O\nunder O\ngames O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\n\nagainst O\n, O\npoints O\n) O\n: O\n\nReal B-ORG\nMadrid I-ORG\n15 O\n10 O\n5 O\n0 O\n31 O\n12 O\n35 O\n\nBarcelona B-ORG\n15 O\n10 O\n4 O\n1 O\n46 O\n19 O\n34 O\n\nDeportivo B-ORG\nCoruna I-ORG\n15 O\n9 O\n6 O\n0 O\n23 O\n7 O\n33 O\n\nReal B-ORG\nBetis I-ORG\n15 O\n8 O\n5 O\n2 O\n28 O\n13 O\n29 O\n\nAtletico B-ORG\nMadrid I-ORG\n15 O\n8 O\n3 O\n4 O\n26 O\n17 O\n27 O\n\nAthletic B-ORG\nBilbao I-ORG\n15 O\n7 O\n4 O\n4 O\n28 O\n22 O\n25 O\n\nReal B-ORG\nSociedad I-ORG\n15 O\n7 O\n3 O\n5 O\n20 O\n18 O\n24 O\n\nValladolid B-ORG\n15 O\n7 O\n3 O\n5 O\n19 O\n18 O\n24 O\n\nRacing B-ORG\nSantander I-ORG\n15 O\n5 O\n7 O\n3 O\n15 O\n15 O\n22 O\n\nRayo B-ORG\nVallecano I-ORG\n15 O\n5 O\n5 O\n5 O\n21 O\n19 O\n20 O\n\nValencia B-ORG\n15 O\n6 O\n2 O\n7 O\n23 O\n22 O\n20 O\n\nCelta B-ORG\nVigo I-ORG\n15 O\n5 O\n5 O\n5 O\n17 O\n17 O\n20 O\n\nTenerife B-ORG\n15 O\n5 O\n4 O\n6 O\n23 O\n17 O\n19 O\n\nEspanyol B-ORG\n15 O\n4 O\n4 O\n7 O\n17 O\n20 O\n16 O\n\nOviedo B-ORG\n15 O\n4 O\n4 O\n7 O\n17 O\n21 O\n16 O\n\nSporting B-ORG\nGijon O\n15 O\n4 O\n4 O\n7 O\n15 O\n22 O\n16 O\n\nLogrones B-ORG\n15 O\n4 O\n3 O\n8 O\n11 O\n33 O\n15 O\n\nZaragoza B-ORG\n15 O\n2 O\n8 O\n5 O\n18 O\n23 O\n14 O\n\nSevilla B-ORG\n15 O\n4 O\n2 O\n9 O\n13 O\n20 O\n14 O\n\nCompostela B-ORG\n15 O\n3 O\n4 O\n8 O\n13 O\n28 O\n13 O\n\nHercules B-ORG\n15 O\n2 O\n2 O\n11 O\n11 O\n29 O\n8 O\n\nExtremadura B-ORG\n15 O\n1 O\n3 O\n11 O\n8 O\n30 O\n6 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSPAIN B-LOC\nPICK O\nUNCAPPED O\nARMANDO B-PER\nFOR O\nWORLD B-MISC\nCUP I-MISC\nCLASH O\n. O\n\nMADRID B-LOC\n1996-12-06 O\n\nSpain B-LOC\ncoach O\nJavier B-PER\nClemente I-PER\nhas O\nadded O\nuncapped O\nDeportivo B-ORG\nCoruna I-ORG\nmidfielder O\nArmando B-PER\nAlvarez I-PER\nto O\nhis O\nsquad O\nfor O\nthe O\nWorld B-MISC\nCup I-MISC\nqualifier O\nagainst O\nYugoslavia B-LOC\non O\nDecember O\n14 O\n. O\n\n\" O\nI O\ndo O\nn't O\nbelieve O\nit O\n... O\n\nI O\nthought O\nit O\nwas O\na O\njoke O\n, O\n\" O\nsaid O\nArmando B-PER\nwho O\nreplaces O\ninjured O\nAtletico B-ORG\nMadrid I-ORG\nplaymaker O\nJose B-PER\nLuis I-PER\nCaminero I-PER\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFIFA B-ORG\nBOSS O\nHAVELANGE B-PER\nSTANDS O\nBY O\nWEAH B-PER\n. O\n\nROME B-LOC\n1996-12-06 O\n\nFIFA B-ORG\nchairman O\nJoao B-PER\nHavelange I-PER\nsaid O\non O\nFriday O\nhe O\nwould O\npersonally O\npresent O\nAC B-ORG\nMilan I-ORG\nGeorge B-PER\nWeah I-PER\nwith O\nworld O\nsoccer O\n's O\nfair O\nplay O\naward O\ndespite O\nthe O\nstriker O\n's O\nattack O\non O\nPorto B-ORG\ncaptain O\nJorge B-PER\nCosta I-PER\n. O\n\nIn O\nan O\ninterview O\nwith O\nthe O\nItalian B-MISC\nnewspaper O\nGazzetta B-ORG\ndello I-ORG\nSport I-ORG\n, O\nhe O\nwas O\nquoted O\nas O\nsaying O\nWeah B-PER\nhad O\nbeen O\nprovoked O\ninto O\nthe O\nassault O\nwhich O\nleft O\nCosta B-PER\nwith O\na O\nbroken O\nnose O\n. O\n\n\" O\nFIFA B-ORG\nhas O\nnamed O\nthe O\nLiberian B-MISC\nfor O\nits O\n1996 O\nFair O\nPlay O\naward O\nand O\nit O\nis O\nnot O\ngoing O\nto O\nchange O\nits O\ndecision O\n, O\n\" O\nHavelange B-PER\nsaid O\n. O\n\n\" O\nA O\nreaction O\n, O\nprovoked O\n, O\ncannot O\nerase O\n10 O\nyears O\nof O\nloyalty O\neverywhere O\nand O\nin O\nevery O\ncompetition O\n. O\n\n\" O\nI O\nwill O\nbe O\nhappy O\nto O\ngive O\nhim O\nthe O\naward O\npersonally O\non O\nJanuary O\n20 O\nin O\nLisbon B-LOC\nand O\nI O\n'm O\nconfident O\nthat O\nCosta B-PER\nhimself O\nwill O\nbe O\nthere O\nbeside O\nme O\non O\nthat O\nday O\nto O\nshake O\nhis O\nhand O\n. O\n\" O\n\nWeah B-PER\nwas O\nsuspended O\nfor O\none O\nmatch O\nby O\nUEFA B-ORG\n, O\nEuropean B-MISC\nsoccer O\n's O\ngoverning O\nbody O\n, O\npending O\na O\nfuller O\ninvestigation O\n. O\n\nThe O\nincident O\ntook O\nplace O\nin O\nthe O\nplayers O\n' O\ntunnel O\nafter O\na O\nEuropean B-MISC\nChampions I-MISC\n' I-MISC\nLeague I-MISC\nmatch O\non O\nNovember O\n20 O\n. O\n\nWeah B-PER\nhas O\nadmitted O\nhead O\nbutting O\nCosta B-PER\nbut O\nsaid O\nhe O\nreacted O\nto O\nracist O\ntaunts O\n. O\n\nHe O\nhas O\noffered O\nto O\napologise O\nif O\nCosta B-PER\nacknowledges O\nthe O\nprovocation O\n. O\n\nCosta B-PER\n, O\nwho O\nneeded O\nsurgery O\non O\nhis O\nnose O\n, O\nhas O\nnot O\naccepted O\nthe O\noffer O\nand O\nwas O\nreported O\nto O\nbe O\nconsidering O\nsuing O\nWeah B-PER\n. O\n\nWeah B-PER\nserved O\nout O\nhis O\nsuspension O\nduring O\nMilan B-ORG\n's O\n2-1 O\nhome O\ndefeat O\nby O\nRosenborg B-ORG\nof O\nNorway B-LOC\non O\nWednesday O\n. O\n\nThe O\ndefeat O\nput O\nthe O\nItalians B-MISC\nout O\nof O\nthe O\nEuropoean B-MISC\nCup I-MISC\n. O\n\n-DOCSTART- O\n\nGUNMEN O\nWOUND O\nTWO O\nMANCHESTER B-ORG\nUNITED I-ORG\nFANS O\nIN O\nAUSTRIA B-LOC\n. O\n\nVIENNA B-LOC\n1996-12-06 O\n\nTwo O\nManchester B-ORG\nUnited I-ORG\nsoccer O\nfans O\nwere O\nwounded O\nby O\nunidentified O\ngunmen O\non O\nFriday O\nand O\ntaken O\nto O\nhospital O\nin O\nthe O\nAustrian B-MISC\ncapital O\n, O\npolice O\nsaid O\n. O\n\n\" O\nThe O\nfour O\nBritons B-MISC\nwere O\nshot O\nat O\nfrom O\na O\nMercedes B-MISC\ncar O\nat O\naround O\n1 O\na.m. O\n, O\n\" O\na O\nspokeswoman O\ntold O\nReuters B-ORG\n. O\n\nThe O\ntwo O\nmen O\nwere O\nhit O\nin O\nthe O\npelvis O\nand O\nleg O\n. O\n\nPolice O\nsaid O\ntheir O\nlives O\nwere O\nnot O\nin O\ndanger O\n. O\n\nThe O\nfans O\n, O\nin O\nAustria B-LOC\nto O\nwatch O\ntheir O\nteam O\nplay O\nRapid B-ORG\nVienna I-ORG\nlast O\nWednesday O\n, O\nmay O\nhave O\nbeen O\ninvolved O\nin O\na O\npub O\nbrawl O\nearlier O\n, O\nthe O\nspokeswoman O\nsaid O\n. O\n\nManchester B-ORG\nUnited I-ORG\nwon O\n2-0 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nITALIAN B-MISC\nFIRST O\nDIVISION O\nMATCHES O\nTHIS O\nWEEKEND O\n. O\n\nROME B-LOC\n1996-12-06 O\n\nItalian B-MISC\nSerie B-MISC\nA I-MISC\ngames O\nto O\nbe O\nplayed O\non O\nSunday O\n( O\nleague O\npositions O\nin O\nparentheses O\n, O\nall O\nkick- O\noff O\ntimes O\nGMT B-MISC\n) O\n: O\n\nBologna B-ORG\n( O\n4 O\n) O\nv O\nPiacenza B-ORG\n( O\n13 O\n) O\n1330 O\n\nAlong O\nwith O\nleaders O\nVicenza B-ORG\n, O\nfourth-placed O\nBologna B-ORG\nrepresent O\nthe O\nbiggest O\nsurprise O\nof O\nthis O\nItalian B-MISC\nautumn O\n. O\n\nLed O\nas O\nusual O\nby O\nSwede B-MISC\nKennet B-PER\nAndersson I-PER\nand O\nRussian B-MISC\nIgor B-PER\nKolyvanov I-PER\nin O\nattack O\n, O\nBologna B-ORG\ncan O\nexpect O\na O\ntough O\nhome O\nmatch O\nagainst O\na O\nPiacenza B-ORG\nside O\nstill O\nexultant O\nafter O\na O\n3-2 O\nleague O\nwin O\nover O\nAC B-ORG\nMilan I-ORG\nlast O\nSunday O\n. O\n\nCagliari B-ORG\n( O\n16 O\n) O\nv O\nReggiana B-ORG\n( O\n18 O\n) O\n1530 O\n\nCagliari B-ORG\nstart O\nfavourite O\nin O\nthis O\nrelegation O\nscrap O\nfollowing O\ndraws O\nwith O\nNapoli B-ORG\nand O\nInter B-ORG\nin O\nlast O\ntwo O\noutings O\nbut O\nwill O\nbe O\nwithout O\nsuspended O\nSwiss B-MISC\ndefender O\nRamon B-PER\nVega I-PER\n. O\n\nBottom O\nteam O\nReggiana B-ORG\nare O\nalso O\nwithout O\na O\nsuspended O\ndefender O\n, O\nGerman B-MISC\nDietmar B-PER\nBeiersdorfer I-PER\n. O\n\nFiorentina B-ORG\n( O\n10 O\n) O\nv O\nPerugia B-ORG\n( O\n8 O\n) O\n1330 O\n\nFiorentina B-ORG\nwill O\nbe O\nwithout O\nthree O\nsuspended O\nplayers O\n-- O\ndefenders O\nDaniele B-PER\nCarnasciali I-PER\nand O\nLorenzo B-PER\nAmoruso I-PER\nand O\nmidfielder O\nEmiliano B-PER\nBigica I-PER\n-- O\nfor O\na O\ndifficult O\nhome O\nmatch O\nagainst O\nunpredictable O\n, O\nattack-oriented O\nPerugia B-ORG\nled O\nby O\nin-form O\nCroat B-MISC\nstriker O\nMilan B-PER\nRapajic I-PER\nand O\nthe O\nexperienced O\nFausto B-PER\nPizzi I-PER\n. O\n\nLazio B-ORG\n( O\n12 O\n) O\nv O\nAS B-ORG\nRoma I-ORG\n( O\n7 O\n) O\n1930 O\n\nPoor O\nman O\n's O\nRoman B-MISC\nderby O\nin O\nwhat O\nhas O\nbeen O\na O\nmiserable O\nseason O\nfor O\nboth O\nRome B-LOC\nteams O\n, O\nalready O\neliminated O\nfrom O\nthe O\nItalian B-MISC\nand O\nUEFA B-MISC\nCups I-MISC\n. O\n\nLazio B-ORG\nhave O\ninjury O\ndoubts O\nabout O\nstriker O\nPierluigi B-PER\nCasiraghi I-PER\n, O\nCzech B-LOC\nmidfielder O\nPavel B-PER\nNedved I-PER\nand O\ndefender O\nPaolo B-PER\nNegro I-PER\n, O\nwhile O\nRoma B-ORG\npresent O\na O\nfull O\nstrength O\nside O\nled O\nby O\nArgentine B-MISC\nAbel B-PER\nBalbo I-PER\n, O\nMarco B-PER\nDelvecchio I-PER\nand O\nFrancesco B-PER\nTotti I-PER\nin O\nattack O\n. O\n\nAC B-ORG\nMilan I-ORG\n( O\n9 O\n) O\nv O\nUdinese B-ORG\n( O\n11 O\n) O\n1330 O\n\nCan O\nMilan B-ORG\nsink O\nany O\nfurther O\n? O\n\nFollowing O\ntheir O\nmidweek O\nChampions B-MISC\n' I-MISC\nLeague I-MISC\nelimination O\nby O\nNorwegian B-MISC\nside O\nRosenborg B-ORG\n, O\na O\nmorale-boosting O\nwin O\nis O\nbadly O\nneeded O\n. O\n\nLiberian B-MISC\nstriker O\nGeorge B-PER\nWeah I-PER\nmakes O\na O\nwelcome O\nreturn O\nfor O\nMilan B-ORG\nalongside O\nRoberto B-PER\nBaggio I-PER\n, O\nwith O\nMontenegrin B-MISC\nDejan B-PER\nSavicevic I-PER\nin O\nmidfield O\n. O\n\nGood O\nnews O\nfor O\nMilan B-ORG\nis O\nthat O\nUdinese B-ORG\n's O\nGerman B-MISC\nstriker O\nOliver B-PER\nBierhoff I-PER\nis O\nout O\nthrough O\ninjury O\n. O\n\nNapoli B-ORG\n( O\n5 O\n) O\nv O\nVerona B-ORG\n( O\n17 O\n) O\n1330 O\n\nIn-form O\nNapoli B-ORG\nshould O\nprove O\ntoo O\nstrong O\nfor O\nsecond O\nfrom O\nbottom O\nVerona B-ORG\ndespite O\nthe O\nabsence O\nof O\ntheir O\nsuspended O\nArgentine B-MISC\ndefender O\nRoberto B-PER\nAyala I-PER\n. O\n\nVerona B-ORG\n's O\nslim O\nchances O\nhave O\nbeen O\nfurther O\nreduced O\nby O\na O\nknee O\ninjury O\nto O\ntheir O\nexperienced O\nmidfielder O\nEugenio B-PER\nCorini I-PER\n. O\n\nParma B-ORG\n( O\n14 O\n) O\nv O\nAtlalanta B-ORG\n( O\n15 O\n) O\n1330 O\n\nParma B-ORG\nmay O\nfield O\nnew O\nsigning O\n, O\nCroat B-MISC\nmidfielder O\nMario B-PER\nStanic I-PER\n, O\nin O\nan O\nattempt O\nto O\nlift O\na O\nmiserable O\nseason O\nwhich O\nhas O\nseen O\nthem O\ngo O\nwithout O\na O\nwin O\nsince O\na O\n1-0 O\ntriumph O\nover O\nCagliari B-ORG\neight O\nweeks O\nago O\n. O\n\nParma B-ORG\n's O\nFrench B-MISC\nmidfielder O\nDaniel B-PER\nBravo I-PER\nand O\ndefender O\nFabio B-PER\nCannavaro I-PER\nare O\nsuspended O\nwhile O\nArgentine B-MISC\nNestor B-PER\nSensini I-PER\nis O\nout O\nthrough O\ninjury O\n. O\n\nAtalanta B-ORG\nlook O\nto O\nFilippo B-PER\nInzaghi I-PER\n, O\nscorer O\nof O\neight O\ngoals O\n. O\n\nSampdoria B-ORG\n( O\n6 O\n) O\nv O\nJuventus B-ORG\n( O\n3 O\n) O\n1330 O\n\nAll-conquering O\nJuventus B-ORG\nfield O\ntheir O\nmost O\nrecent O\nsigning O\n, O\nPortuguese B-MISC\ndefender O\nDimas B-PER\n, O\nwhile O\nAlessandro B-PER\nDel I-PER\nPiero I-PER\nand O\nCroat B-MISC\nAlen B-PER\nBoksic I-PER\nlead O\nthe O\nattack O\n. O\n\nThe O\nnew O\nworld O\nclub O\nchampions O\nmay O\nprove O\ntoo O\nstrong O\nfor O\na O\nSampdoria B-ORG\nside O\nled O\nby O\ncaptain O\nRoberto B-PER\nMancini I-PER\nbut O\nmissing O\ninjured O\nFrench B-MISC\nmidfielder O\nPierre B-PER\nLaigle I-PER\n. O\n\nVicenza B-ORG\n( O\n1 O\n) O\nv O\nInternazionale B-ORG\n( O\n2 O\n) O\n1330 O\n\nNot O\nexactly O\na O\nclash O\nof O\nthe O\ntitans O\nbut O\nan O\nintriuguing O\nmatch O\nnonetheless O\n. O\n\nFull O\nstrength O\nVicenza B-ORG\n, O\nled O\nby O\nUruguayan B-MISC\nMarcelo B-PER\nOtero I-PER\n, O\nmay O\ncontinue O\ntheir O\nsurprise O\nrun O\nat O\nthe O\ntop O\nagainst O\nan O\nInter B-ORG\nside O\nthat O\nhas O\nbeen O\nless O\nthan O\nimpressive O\nin O\nthree O\nsuccessive O\nhome O\ndraws O\n. O\n\nInter B-ORG\nwill O\nbe O\nwithout O\nsuspended O\nFrench B-MISC\ndefender O\nJoceyln B-PER\nAngloma I-PER\nand O\ninjured O\nChilean B-MISC\nstriker O\nIvan B-PER\nZamorano I-PER\n. O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nEUROLEAGUE B-MISC\nRESULT O\n. O\n\nBRUSSELS B-LOC\n1996-12-06 O\n\nResult O\nof O\na O\nEuroLeague B-MISC\nbasketball O\nmatch O\non O\nThursday O\n: O\n\nGroup O\nB O\n\nIn O\nCharleroi B-LOC\n: O\n\nCharleroi B-ORG\n( O\nBelgium B-LOC\n) O\n75 O\nEstudiantes B-ORG\nMadrid I-ORG\n( O\nSpain B-LOC\n) O\n82 O\n( O\n34-35 O\n) O\n\nLeading O\nscorers O\n: O\n\nCharleroi B-ORG\n- O\nEric B-PER\nCleymans I-PER\n18 O\n, O\nRon B-PER\nEllis I-PER\n18 O\n, O\nJacques B-PER\nStas I-PER\n14 O\n\nEstudiantes B-ORG\n- O\nHarper B-PER\nWilliams I-PER\n20 O\n, O\nChadler B-PER\nThompson I-PER\n17 O\n, O\nJuan B-PER\nAisa I-PER\n14 O\n\nGroup O\nD O\n\nIn O\nBelgrade B-LOC\n: O\n\nPartizan B-ORG\nBelgrade I-ORG\n( O\nYugoslavia B-LOC\n) O\n78 O\nKinder B-ORG\nBologna I-ORG\n( O\nItaly B-LOC\n) O\n70 O\n( O\nhalftime O\n44-35 O\n) O\n\nLeading O\nscorers O\n: O\n\nPartizan B-ORG\n- O\nDejan B-PER\nKoturovic I-PER\n21 O\n\nKinder O\n- O\nZoran B-PER\nSavic I-PER\n18 O\n\n-DOCSTART- O\n\nSQUASH O\n- O\nEYLES B-PER\nWITHIN O\nSIGHT O\nOF O\nFIFTH O\nTITLE O\nOF O\nYEAR O\n. O\n\nBOMBAY B-LOC\n, O\nIndia B-LOC\n1996-12-06 O\n\nWorld O\nnumber O\ntwo O\nRodney B-PER\nEyles I-PER\nmoved O\nwithin O\nsight O\nof O\nhis O\nfifth O\ntitle O\nof O\nthe O\nyear O\non O\nFriday O\nwhen O\nhe O\nhurried O\nin O\nonly O\n40 O\nminutes O\nto O\nthe O\nfinal O\nof O\nthe O\nrichest O\nsquash O\ntournament O\noutside O\nthe O\nWorld B-MISC\nOpen I-MISC\n, O\nthe O\n$ O\n105,000 O\nMahindra B-MISC\nInternational I-MISC\n. O\n\nThe O\nAustralian B-MISC\nbrushed O\naside O\nunseeded O\nEnglishman B-MISC\nMark B-PER\nCairns I-PER\n15-7 O\n15-6 O\n15-8 O\n. O\n\nTop-seeded O\nEyles B-PER\nnow O\nmeets O\ntitleholder O\nPeter B-PER\nNicol I-PER\nof O\nScotland B-LOC\nwho O\novercame O\nSimon B-PER\nParke I-PER\nof O\nEngland B-LOC\n15-7 O\n15-12 O\n15-12 O\n. O\n\nNicol B-PER\nwas O\nfull O\nof O\npraise O\nfor O\nhis O\nopponent O\nwho O\nhas O\nbattled O\ntesticular O\ncancer O\nto O\nreturn O\nto O\nthe O\ncircuit O\n. O\n\" O\n\nHe O\n's O\na O\nremarkably O\ncourageous O\nplayer O\n, O\n\" O\nsaid O\nNicol B-PER\n. O\n\n-DOCSTART- O\n\nSQUASH O\n- O\nMAHINDRA B-MISC\nINTERNATIONAL I-MISC\nSEMIFINAL O\nRESULTS O\n. O\n\nBOMBAY B-LOC\n, O\nIndia B-LOC\n1996-12-06 O\n\nResults O\nof O\nsemifinals O\nin O\nthe O\nMahindra B-MISC\nInternational I-MISC\nsquash O\ntournament O\non O\nFriday O\n: O\n\nPeter B-PER\nNicol I-PER\n( O\nScotland B-LOC\n) O\nbeat O\nSimon B-PER\nParke I-PER\n( O\nEngland B-LOC\n) O\n15-7 O\n15-12 O\n15-12 O\nRodney B-PER\nEyles I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nMark B-PER\nCairns I-PER\n( O\nEngland B-LOC\n) O\n15-7 O\n15-6 O\n15-8 O\n. O\n\nFinal O\n: O\nNicol B-PER\nv O\nEyles B-PER\n, O\non O\nSaturday O\n. O\n\n-DOCSTART- O\n\nGUNMEN O\nKILL O\nFOUR O\nIN O\nS.AFRICA B-MISC\n'S O\nZULU B-MISC\nPROVINCE O\n. O\n\nDURBAN B-PER\n, O\nSouth B-LOC\nAfrica I-LOC\n1996-12-06 O\n\nAt O\nleast O\nfour O\npeople O\nhave O\nbeen O\nshot O\ndead O\nin O\ntwo O\nsuspected O\npolitical O\nattacks O\nin O\nSouth B-LOC\nAfrica I-LOC\n's O\nvolatile O\nZulu B-MISC\nheartland O\n, O\npolice O\nsaid O\non O\nFriday O\n. O\n\nA O\npolice O\nspokesman O\nsaid O\ntwo O\nyouths O\nbelieved O\nto O\nbe O\nsupporters O\nof O\nPresident O\nNelson B-PER\nMandela I-PER\n's O\nAfrican B-ORG\nNational I-ORG\nCongress I-ORG\n( O\nANC B-ORG\n) O\nhad O\nbeen O\nkilled O\nwhen O\nunknown O\ngunmen O\nopened O\nfire O\nat O\nthe O\nrural O\nsettlement O\nof O\nIzingolweni B-LOC\non O\nKwaZulu-Natal B-LOC\nprovince O\n's O\nsouth O\ncoast O\non O\nThursday O\nnight O\n. O\n\nThe O\nvictims O\nwere O\n18 O\nand O\n20 O\n, O\nhe O\nsaid O\n, O\nadding O\none O\nother O\nyouth O\nhad O\nbeen O\nwounded O\nin O\nthe O\nshooting O\n. O\n\nIn O\nanother O\nattack O\n, O\nalso O\non O\nthe O\nprovince O\n's O\nsouth O\ncoast O\non O\nThursday O\nnight O\n, O\ntwo O\nmen O\nwere O\nshot O\ndead O\nnear O\nUmkomaas B-LOC\n. O\n\n\" O\nWe O\nsuspect O\nthat O\nthese O\nkillings O\nare O\nlinked O\nto O\npolitics O\n, O\n\" O\nspokesman O\nBala B-PER\nNaidoo I-PER\ntold O\nReuters B-ORG\n. O\n\nThere O\nhad O\nbeen O\nno O\narrests O\n. O\n\nThe O\nkillings O\ncame O\njust O\nhours O\nafter O\nviolence O\nmonitors O\nsaid O\nthey O\nwere O\nnot O\noptimistic O\nof O\na O\npeaceful O\nfestive O\nseason O\nin O\nKwaZulu-Natal B-LOC\nand O\npointed O\nthe O\nsouth O\ncoast O\nregion O\nwhere O\n18 O\npeople O\nwere O\nmassacred O\nlast O\nChristmas O\nas O\none O\nof O\npotential O\nhot O\nspots O\n. O\n\nThey O\nsaid O\nthe O\nrecent O\nlull O\nin O\npolitical O\nfeuding O\ncould O\nbe O\nupset O\nas O\nthousands O\nof O\nmigrant O\nworkers O\n, O\nsome O\ntense O\nwith O\ngrudges O\nbrewed O\nin O\nthe O\ncities O\nand O\nkeen O\nto O\nsettle O\nold O\nscores O\n, O\nflock O\nback O\nto O\ntheir O\nhome O\nvillages O\n. O\n\nMore O\nthan O\n14,000 O\npeople O\nhave O\nlost O\ntheir O\nlives O\nin O\nover O\na O\ndecade O\nof O\npolitical O\nturf O\nwars O\nbetween O\nthe O\nANC B-ORG\nand O\nZulu B-MISC\nChief O\nMangosuthu B-PER\nButhelezi I-PER\n's O\nInkatha B-ORG\nFreedom I-ORG\nParty I-ORG\nin O\nthe O\nprovince O\n. O\n\n-DOCSTART- O\n\nHAVEL B-PER\nPRAISES O\nCZECH B-MISC\nNATIVE O\nALBRIGHT B-PER\nAS O\nFRIEND O\n. O\n\nKlara B-PER\nGajduskova I-PER\n\nPRAGUE B-LOC\n1996-12-06 O\n\nCzech B-LOC\nPresident O\nVaclav B-PER\nHavel I-PER\non O\nFriday O\nwelcomed O\nthe O\nappointment O\nof O\nMadeleine B-PER\nAlbright I-PER\n, O\nwho O\nis O\nof O\nCzech B-LOC\nextraction O\n, O\nas O\nthe O\nUnited B-LOC\nStates I-LOC\n' O\nfirst O\nwoman O\nSecretary O\nof O\nState O\n. O\n\nIn O\na O\nstatement O\nHavel B-PER\n, O\nwho O\nis O\nrecovering O\nfrom O\ncancer O\nsurgery O\n, O\nsaid O\n: O\n\" O\nMadeleine B-PER\nAlbright I-PER\nis O\na O\ndistinguished O\nfriend O\n, O\na O\ntested O\ndiplomat O\n, O\nand O\na O\ntrue O\nAmerican B-MISC\nof O\nfine O\norigins O\n. O\n\" O\n\n\" O\nI O\nlook O\nforward O\nto O\ncontinuing O\nour O\ngood O\nrelations O\n... O\n\nwith O\nthe O\nUnited B-LOC\nStates I-LOC\nand O\nwith O\nthe O\nfirst O\nwoman O\never O\nto O\nhold O\nthe O\nposition O\nof O\nSecretary O\nof O\nState O\n. O\n\nI O\nwish O\nher O\nwell O\n, O\n\" O\nHavel B-PER\nsaid O\nin O\na O\nstatement O\nto O\nReuters B-ORG\n. O\n\nHavel B-PER\n, O\nwho O\nhelped O\nlead O\nthe O\n\" O\nvelvet O\nrevolution O\n\" O\nthat O\nousted O\nthe O\nCommunist B-MISC\nregime O\nin O\nPrague B-LOC\nin O\n1989 O\n, O\ninvited O\nAlbright B-PER\n, O\nthen O\nworking O\nfor O\na O\nprivate O\nforeign O\npolicy O\nthink O\ntank O\n, O\nto O\nadvise O\nhis O\nnew O\ndemocratic O\ngovernment O\nin O\n1990 O\n. O\n\nHavel B-PER\nhad O\na O\nsmall O\nmalignant O\ntumour O\nremoved O\nfrom O\nhis O\nlung O\non O\nMonday O\nand O\nis O\nrecovering O\nin O\nhospital O\n. O\n\nAlbright B-PER\n, O\nborn O\nMarie B-PER\nKorbelova I-PER\nto O\na O\nCzechoslovak B-MISC\ndiplomat O\nin O\n1937 O\n, O\nfled O\nwith O\nher O\nfamily O\nto O\nthe O\nUnited B-LOC\nStates I-LOC\nafter O\nthe O\nCommunists B-MISC\ncame O\nto O\npower O\nin O\na O\ncoup O\nin O\n1948 O\n. O\n\nAs O\nan O\nacademic O\n, O\nAlbright B-PER\nstudied O\nand O\nlectured O\non O\nEurope B-LOC\n's O\n20th O\ncentury O\nproblems O\nbefore O\nbecoming O\nU.S. B-LOC\nambassador O\nto O\nthe O\nUnited B-ORG\nNations I-ORG\n. O\n\nCzech B-LOC\ndiplomats O\n, O\nseeking O\nto O\nhave O\ntheir O\ncountry O\nincluded O\nin O\nthe O\nexpected O\nexpansion O\nof O\nNATO B-ORG\n, O\npraised O\nthe O\nselection O\nof O\nAlbright B-PER\n, O\nknown O\nto O\nbe O\na O\nstrong O\nsupporter O\nof O\nalliance O\n's O\nintegration O\nof O\nformer O\nSoveit-bloc B-MISC\ncountries O\n. O\n\n\" O\nThe O\nnomination O\n... O\n\nis O\na O\nclear O\nsignal O\nthat O\none O\nkey O\nof O\nthe O\nlines O\nof O\nforeign O\npolicy O\nwill O\nbe O\nthe O\nstrengthening O\nof O\nthe O\ntrans-Atlantic B-MISC\ncooperation O\n, O\na O\ncreation O\nof O\nstrategic O\npartnership O\nbetween O\nEurope B-LOC\nand O\nthe O\nUS B-LOC\n, O\n\" O\nForeign O\nMinister O\nJosef B-PER\nZieleniec I-PER\ntold O\nReuters B-ORG\n. O\n\n\" O\n( O\nAlbright B-PER\n) O\nis O\na O\nconvinced O\nadvocate O\nof O\nNATO B-ORG\nenlargement O\nand O\nof O\nstabilisation O\nof O\nsecurity O\nstructures O\n. O\n\" O\n\nCzech B-LOC\nambassador O\nto O\nthe O\nUnited B-ORG\nNations I-ORG\n, O\nKarel B-PER\nKovanda I-PER\n, O\ntold O\nthe O\ndaily O\nMlada B-ORG\nFronta I-ORG\nDnes I-ORG\nthat O\nAlbright B-PER\n\" O\nis O\na O\nlittle O\nlight O\nin O\nour O\ndiplomatic O\nheaven O\n, O\n\" O\nbut O\nwarned O\nagainst O\nexpecting O\nher O\nto O\nexert O\nany O\ninfluence O\nin O\nfavour O\nof O\nthe O\nCzechs B-MISC\n. O\n\n-DOCSTART- O\n\nRADIO B-ORG\nROMANIA I-ORG\nAFTERNOON O\nHEALINES O\nAT O\n4 O\nPM O\n. O\n\nBUCHAREST B-LOC\n1996-12-06 O\n\nRadio B-ORG\nRomania I-ORG\nnews O\nheadlines O\n: O\n\n* O\nThe O\nDemocratic B-MISC\nConvention I-MISC\nsigned O\nan O\nagreement O\non O\ngovernment O\nand O\nparliamentary O\nsupport O\nwith O\nits O\ncoalition O\npartners O\nthe O\nSocial B-ORG\nDemocratic I-ORG\nUnion I-ORG\nand O\nthe O\nHungarian B-ORG\nDemocratic I-ORG\nUnion I-ORG\n( O\nUDMR B-ORG\n) O\n. O\n\nThe O\nceremony O\nwas O\nattended O\nby O\nPresident O\nEmil B-PER\nConstantinescu I-PER\n. O\n\n* O\nThe O\nthree O\nparties O\nin O\nthe O\ngovernment O\ncoalition O\nhave O\ncommitted O\nthemselves O\nto O\na O\nreal O\nreform O\nof O\nRomania B-LOC\n's O\neconomy O\n, O\nConstantinescu B-PER\nsaid O\nafter O\nthe O\nceremony O\n. O\n\n* O\nThe O\nUDMR B-ORG\nwants O\nto O\ncontribute O\nto O\nsocial O\nreform O\nand O\neconomic O\nrevival O\nin O\nRomania B-LOC\n, O\nunion O\nleader O\nMarko B-PER\nBela I-PER\nsaid O\n. O\n\n* O\nThe O\ninternational O\nairport O\nin O\nTimisoara B-LOC\nand O\nthe O\ndomestic O\nairports O\nin O\nArad B-LOC\n, O\nOradea B-LOC\nand O\nSibiu B-LOC\nwere O\nclosed O\ndue O\nto O\nfog O\n. O\n\n-- O\nBucharest B-ORG\nNewsroom I-ORG\n40-1 O\n3120264 O\n\n-DOCSTART- O\n\nCZECH B-MISC\nVICE-PM O\nSEES O\nWIDER O\nDEBATE O\nAT O\nPARTY O\nCONGRESS O\n. O\n\nPRAGUE B-LOC\n1996-12-06 O\n\nSaturday O\n's O\nnational O\ncongress O\nof O\nthe O\nruling O\nCzech B-ORG\nCivic I-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nODS B-ORG\n) O\nwill O\ndiscuss O\nmaking O\nthe O\nparty O\nmore O\nefficient O\nand O\ntransparent O\n, O\nForeign O\nMinister O\nand O\nODS B-ORG\nvice-chairman O\nJosef B-PER\nZieleniec I-PER\n, O\nsaid O\non O\nFriday O\n. O\n\n\" O\nModernisation O\nand O\nmore O\nprofesionalism O\nof O\nthe O\nparty O\n's O\nstructure O\n, O\nhaving O\nfinancing O\nof O\nthe O\nparty O\nbe O\nmore O\ntransparent O\n... O\n\nare O\nabsolutely O\nfundamental O\n, O\n\" O\nZieleniec B-PER\n, O\nwho O\nis O\nalso O\nvice-premier O\nin O\nthe O\ngovernment O\n, O\ntold O\nReuters B-ORG\n. O\n\nHe O\nsaid O\nafter O\nJune O\ngeneral O\nelections O\nin O\nwhich O\nthe O\nruling O\nthree-party O\ncoalition O\nlost O\nits O\nparliamentary O\nmajority O\n, O\nthe O\nODS B-ORG\nexecutive O\n, O\nled O\nby O\nPrime O\nMinister O\nVaclav B-PER\nKlaus I-PER\n, O\nhad O\ndeveloped O\nproposals O\non O\nthese O\nsubjects O\nto O\npresent O\nat O\nthe O\ncongress O\non O\nSaturday O\nin O\nthe O\nCzech B-LOC\nsecond O\ncity O\nBrno B-LOC\n. O\n\n\" O\nI O\nam O\nconvinced O\n, O\nthat O\nthe O\ncongress O\nwill O\ntackle O\nthese O\nproposals O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\nODS B-ORG\n, O\na O\nparty O\nin O\nwhich O\nKlaus B-PER\noften O\ntries O\nto O\nemulate O\nthe O\nstyle O\nof O\nformer O\nBritish B-MISC\nPrime O\nMinister O\nMargaret B-PER\nThatcher I-PER\n, O\nhas O\nbeen O\nin O\ncontrol O\nof O\nCzech B-LOC\npolitics O\nsince O\nwinning O\ngeneral O\nelections O\nin O\n1992 O\n. O\n\nZieleniec B-PER\nin O\nthe O\nsummer O\nled O\ncalls O\nfor O\nthe O\nparty O\nand O\nits O\nleadership O\nto O\nlisten O\nto O\nmore O\ndiverse O\nopinions O\n, O\na O\nthinly-veiled O\ncriticism O\nof O\nKlaus B-PER\nwho O\nhas O\nspearheaded O\nthe O\ncountry O\n's O\npost-Communist B-MISC\neconomic O\nreforms O\n. O\n\nThe O\nparty O\n, O\nled O\nby O\nthe O\nvigorously-confident O\nKlaus B-PER\n, O\ntook O\n32 O\nof O\n81 O\nseats O\nafter O\nlate O\nNovember O\nrunoff O\nelections O\nto O\nthe O\nnew O\nupper O\nhouse O\nof O\nCzech B-LOC\nparliament O\n. O\n\nBut O\nafter O\nthe O\nfirst O\nround O\nvote O\na O\nweek O\nbefore O\n, O\nthe O\nODS B-ORG\nhad O\nthe O\npotential O\nto O\nwin O\nas O\nmany O\n79 O\nseats O\n. O\n\nKlaus B-PER\nand O\nhis O\ncoalition O\nlost O\nits O\nmajority O\nin O\nparliament O\nin O\nJune O\nlower O\nhouse O\nelections O\nafter O\nthe O\nleft-wing O\nopposition O\nconsolidated O\n, O\nputting O\nthe O\ncentre-left O\nSocial B-MISC\nDemocrats I-MISC\nin O\na O\nstrong O\nsecond-place O\nposition O\n. O\n\n-- O\nPrague B-ORG\nNewsroom I-ORG\n42-2-2423-0003 O\n\n-DOCSTART- O\n\nPOLAND B-LOC\nGOT O\nMONEY O\nFROM O\nPOST-WAR O\nSWISS B-MISC\nACCOUNTS O\n. O\n\nMarcin B-PER\nGrajewski I-PER\n\nWARSAW B-LOC\n1996-12-06 O\n\nPoland B-LOC\nsaid O\non O\nFriday O\nthat O\nSwiss B-MISC\nbank O\naccounts O\n, O\nwhich O\nin O\nmany O\ncases O\nbelonged O\nto O\nPolish B-MISC\nJews B-MISC\nwho O\ndied O\nin O\nthe O\nHolocaust B-MISC\n, O\nwere O\nused O\nin O\ndebt O\nsettlements O\nbetween O\nthe O\ntwo O\ncountries O\nafter O\nthe O\nWorld B-MISC\nWar I-MISC\nTwo I-MISC\n. O\n\nForeign O\nMinister O\nDariusz B-PER\nRosati I-PER\n, O\nunveiling O\nfirst O\nfindings O\nof O\na O\nspecial O\ngovernment O\ncommission O\n, O\nsaid O\nthat O\nin O\n1970s O\nthe O\nthen O\ncommunist O\nPoland B-LOC\nreceived O\n460,000 O\nSwiss B-MISC\nfrancs O\nfrom O\nthe O\naccounts O\n. O\n\n\" O\nIn O\n1970s O\n, O\nPoland B-LOC\nreceived O\nfrom O\nunclaimed O\naccounts O\nin O\nSwitzerland B-LOC\na O\nsum O\nof O\n460,000 O\nfrancs O\n. O\n\nWhat O\nwas O\nits O\nright O\n( O\nto O\nthe O\nmoney O\n) O\n...I O\ndo O\nnot O\nknow O\n, O\n\" O\nRosati B-PER\ntold O\na O\nnews O\nconference O\n. O\n\nSwitzerland B-LOC\nstands O\naccused O\nby O\nSenator O\nAlfonse B-PER\nD'Amato I-PER\n, O\nchairman O\nof O\nthe O\npowerful O\nU.S. B-ORG\nSenate I-ORG\nBanking I-ORG\nCommittee I-ORG\n, O\nof O\nagreeing O\nto O\ngive O\nmoney O\nto O\nPoland B-LOC\nfrom O\nunclaimed O\nbank O\naccounts O\nof O\nPolish B-MISC\ncitizens O\n, O\nas O\npart O\nof O\nan O\naccord O\non O\ncompensating O\nSwiss B-MISC\nnationals O\nwhose O\nassets O\nhad O\nbeen O\nseized O\nin O\ncommunist O\nPoland B-LOC\n. O\n\nMany O\nof O\nthese O\ncitizens O\nwere O\nJews B-MISC\nmurdered O\nduring O\nthe O\nwar O\n, O\nwhen O\nNazi B-MISC\nGerman B-MISC\ninvaders O\nkilled O\nmost O\nof O\nPoland B-LOC\n's O\n3.5 O\nmillion O\nJews B-MISC\n. O\n\nRosati B-PER\ndid O\nnot O\nsay O\nwhether O\nthe O\npayment O\nin O\n1970s O\nwas O\npart O\nof O\nthe O\n1949 O\nagreement O\nbetween O\nWarsaw B-LOC\nand O\nSwitzerland B-LOC\non O\ncompensation O\nto O\nSwiss B-MISC\ncitizens O\nwhose O\nassets O\nwere O\nseized O\nby O\nthe O\nSoviet-imposed B-MISC\ncommunists O\nauthorities O\nafter O\nWorld B-MISC\nWar I-MISC\nTwo I-MISC\n. O\n\n\" O\nI O\nexpect O\nthat O\nthe O\ncommission O\nwill O\nfinish O\ngathering O\ninformation O\nwithin O\ntwo O\nto O\nthree O\nweeks O\nand O\nthen O\nmore O\ndetails O\nwill O\nbe O\nprovided O\n, O\n\" O\nRosati B-PER\nsaid O\n. O\n\nRosati B-PER\nconfirmed O\nthat O\nthe O\n1949 O\nagreement O\nhad O\nprovided O\nfor O\ngranting O\nSwitzerland B-LOC\nabout O\n53 O\nmillion O\nfrancs O\nand O\nmost O\nof O\nthis O\nsum O\nwas O\nrepaid O\nwith O\ncoal O\nexports O\n. O\n\nHe O\nsaid O\n, O\nhowever O\n, O\nthat O\nSwitzerland B-LOC\ndid O\nget O\nabout O\n16,000 O\nfrancs O\nfrom O\nthe O\nso-called O\n\" O\ndead O\naccounts O\n\" O\nas O\npart O\nof O\nthe O\ncompensation O\n. O\n\n\" O\nAbout O\n16,000 O\nfrancs O\nwere O\nseized O\nfrom O\naccounts O\nof O\nfour O\nor O\nfive O\nPolish B-MISC\ncitizens O\n, O\nwhose O\ndata O\nwe O\ndo O\nnot O\nprecisely O\nknow O\n. O\n\nThe O\nissue O\nis O\nof O\nmoral O\nand O\nlegal O\nnature O\n, O\nbecause O\nits O\nfinancial O\nsignificance O\nis O\nsmall O\n, O\n\" O\nRosati B-PER\nsaid O\n. O\n\nUnder O\npressure O\nfrom O\ninternational O\nJewish B-MISC\norganisations O\n, O\nSwiss B-MISC\ngovernment O\nhas O\ndevised O\na O\nplan O\nto O\npay O\nout O\nmillions O\nof O\ndollars O\nin O\nunclaimed O\nbank O\naccounts O\nas O\na O\nconciliatory O\ngesture O\ntoward O\nHolocaust B-MISC\nvictims O\n. O\n\nThe O\nconservative O\nRadical B-ORG\nDemocrats I-ORG\n( O\nFDP B-ORG\n) O\nhave O\nsaid O\nthey O\nwould O\nask O\nparliament O\nnext O\nweek O\nto O\norder O\nSwiss B-MISC\nbanks O\nto O\nput O\nsome O\n40 O\nmillion O\nSwiss B-MISC\nfrancs O\n( O\n$ O\n31 O\nmillion O\n) O\nin O\ndormant O\nwealth O\ninto O\na O\nfund O\nearmarked O\nfor O\nJewish B-MISC\ngroups O\nand O\ncharitable O\norganisations O\n. O\n\nBut O\nSwiss B-MISC\nbanks O\nand O\nthe O\ncountry O\n's O\nJewish B-MISC\ncommunity O\nvoiced O\ndoubts O\nwhether O\nthe O\nplan O\nwould O\nwork O\n. O\n\n-DOCSTART- O\n\nINTERVIEW-ZYWIEC B-MISC\nSEES O\nNO O\nBIG O\n97 O\nNET O\nRISE O\n. O\n\nSteven B-PER\nSilber I-PER\n\nWARSAW B-LOC\n1996-12-06 O\n\nPolish B-MISC\nbrewer O\nZywiec B-ORG\n's O\n1996 O\nprofit O\nslump O\nmay O\nlast O\ninto O\nnext O\nyear O\ndue O\nin O\npart O\nto O\nhefty O\ndepreciation O\ncharges O\n, O\nbut O\nrecent O\nhigh O\ninvestment O\nshould O\nhelp O\nthe O\nfirm O\ndefend O\nits O\n10-percent O\nmarket O\nshare O\n, O\nthe O\nfirm O\n's O\nchief O\nexecutive O\nsaid O\n. O\n\nCompany O\nPresident O\nJean B-PER\nvan I-PER\nBoxmeer I-PER\ntold O\nReuters B-ORG\nin O\nan O\ninterview O\non O\nFriday O\nthat O\nthe O\nfirm O\n, O\nwhose O\nnet O\nprofit O\nfell O\n77 O\npercent O\nin O\nthe O\nfirst O\n10 O\nmonths O\nof O\n1996 O\ndespite O\na O\n30-percent O\nrise O\nin O\nsales O\n, O\nmight O\nonly O\npost O\nslightly O\nbetter O\nprofits O\nin O\n1997 O\nbefore O\nhaving O\na O\nchance O\nto O\nmake O\na O\nmore O\nsignificant O\nturnaround O\n. O\n\nSo O\nfar O\nthis O\nyear O\nZywiec B-ORG\n, O\nwhose O\nfull O\nname O\nis O\nZaklady B-ORG\nPiwowarskie I-ORG\nw I-ORG\nZywcu I-ORG\nSA I-ORG\n, O\nhas O\nnetted O\nsix O\nmillion O\nzlotys O\non O\nsales O\nof O\n224 O\nmillion O\nzlotys O\n. O\n\nIt O\nhas O\nproduced O\n1.5 O\nmillion O\nhectolitres O\n. O\n\nVan B-PER\nBoxmeer I-PER\nwould O\nnot O\nsay O\nhow O\nmuch O\nhigher O\n1997 O\nprofits O\nor O\nmarket O\nshare O\ncould O\nbe O\nbut O\nsaid O\nsales O\nof O\nleading O\nPolish B-MISC\nbrewers O\nshould O\nrise O\nas O\nthe O\ncountry O\n's O\nyoung O\nurban O\nprofessionals O\ngradually O\nswitch O\nfrom O\nvodka O\nto O\nbeer O\n. O\n\n\" O\nThe O\nperspective O\non O\ngrowth O\nis O\nsuch O\nthat O\nreasonably O\nwe O\ncan O\nthink O\nthat O\nsomewhere O\nbetween O\n65 O\nand O\n80 O\nlitres O\nper O\nyear O\nis O\ncertainly O\nreachable O\n, O\n\" O\nvan O\nBoxmeer B-PER\nsaid O\non O\nPolish B-MISC\nper-capita O\nbeer O\nconsumption O\n, O\ncurrently O\naround O\n40 O\nlitres O\n. O\n\nHe O\nsaid O\nthe O\n65-80-litre O\nlevel O\ncould O\nbe O\nreached O\nin O\nthe O\nnext O\nten O\nyears O\nand O\nmake O\nPoland B-LOC\n, O\nwith O\nits O\n40-million O\npopulation O\n, O\nEurope B-LOC\n's O\nthird O\nlargest O\nbeer O\nmarket O\nafter O\nGermany B-LOC\nand O\nBritain B-LOC\n. O\n\nVan B-PER\nBoxmeer I-PER\nsaid O\nPoland B-LOC\n's O\ntop O\nfive O\nbrewers O\n, O\nwhich O\nproduce O\nabout O\n55 O\npercent O\nof O\nthe O\ncountry O\n's O\nbeer O\n, O\ncould O\nall O\nraise O\nmarket O\nshare O\nas O\nsome O\nof O\nthe O\nnumerous O\nsmall O\nbrewers O\nfall O\nto O\ncompetition O\nfrom O\nthe O\nlarge O\nbrewers O\nwith O\nforeign O\ninvestors O\n. O\n\nZywiec B-ORG\nis O\n31.8-percent O\nowned O\nby O\nHeineken B-ORG\nwhile O\nCarlsberg B-ORG\nhas O\nthe O\nsame O\namount O\nin O\nOkocim B-ORG\n. O\n\nEarlier O\nthis O\nyear O\nSouth B-ORG\nAfrican I-ORG\nBreweries I-ORG\nLtd I-ORG\n( O\nSAB B-ORG\n) O\nbought O\nstrategic O\nstakes O\nin O\nthe O\nunlisted O\nLech B-ORG\nand O\nTychy B-ORG\nbrewers O\n, O\nwhich O\ntogether O\nhold O\nmore O\nthan O\n20 O\npercent O\nof O\nthe O\nmarket O\n, O\nand O\nAustralia B-LOC\n's O\nBrewpole B-ORG\nBV I-ORG\nhas O\na O\ncontrolling O\nstake O\nin O\nPoland B-LOC\n's O\nlarges O\nt O\nbrewery O\n, O\nElbrewery B-ORG\nCompany I-ORG\nLtd. I-ORG\n( O\nEB B-ORG\n) O\n. O\n\nVan B-PER\nBoxmeer I-PER\nsaid O\nthe O\ntough O\ncompetition O\nhad O\nprevented O\nZywiec B-ORG\nfrom O\nraising O\nprices O\nin O\nline O\nwith O\ninflation O\n, O\nwhich O\nhad O\nadded O\nto O\nthe O\npressure O\non O\nthe O\nfirm O\n's O\nmargins O\n. O\n\nHe O\nsaid O\nadvertising O\ncosts O\nwould O\nalso O\nincrease O\nin O\nthe O\nfight O\nfor O\nmarket O\nshare O\n. O\n\nBut O\nhe O\nsaid O\nthe O\ncompany O\n's O\ninvestment O\nof O\nmore O\nthan O\n$ O\n100 O\nmillion O\nalready O\nthis O\ndecade O\n, O\nlargely O\nin O\nproduction O\n, O\nwould O\nhelp O\nposition O\nit O\nto O\ncompete O\nwith O\nsuch O\ncompetitors O\nas O\nbrewers O\nfrom O\nthe O\nneighbouring O\nCzech B-LOC\nRepublic I-LOC\n. O\n\nSome O\nanalysts O\nsay O\ncheaper O\nbut O\nhigh-quality O\nCzech B-LOC\nimports O\ncould O\ninvade O\nPoland B-LOC\nonce O\ntariffs O\nfor O\nCEFTA B-ORG\ncountries O\nare O\nlifted O\nin O\n1998 O\n, O\nbut O\nvan O\nBoxmeer B-PER\nsays O\nsuch O\na O\nthreat O\nmight O\nbe O\nexaggerated O\ndespite O\nthe O\nCzech B-LOC\nbeer O\nmarket O\n's O\novercapacity O\n. O\n\n\" O\nI O\nthink O\nPolish B-MISC\nconsumers O\nin O\ngeneral O\nare O\nquite O\nproud O\nof O\ntheir O\nbeers O\n-- O\nand O\nI O\n'm O\nspeaking O\nabout O\nall O\nthe O\nbrands O\n-- O\nand O\nas O\nwe O\nmake O\ngood O\nbeers O\n... O\n\nI O\nthink O\nthat O\nthis O\nfidelity O\nto O\nour O\nbeers O\nis O\na O\nfactor O\nwhich O\ncan O\nlimit O\nthe O\nCzech B-LOC\nbeers O\n, O\n\" O\nhe O\nsaid O\n. O\n\nVan B-PER\nBoxmeer I-PER\nsaid O\nZywiec B-ORG\nhad O\nits O\neye O\non O\nOkocim B-ORG\n, O\nwhich O\nhas O\nsaid O\nit O\nwould O\nstart O\nproducing O\nCarlsberg B-ORG\nbeer O\nnext O\nyear O\n, O\nbut O\nthat O\nZywiec B-ORG\n's O\npotential O\nproduction O\nof O\nHeineken B-ORG\nwas O\na O\nmedium-term O\npossibility O\nrather O\nthan O\na O\nshort-term O\none O\n. O\n\nHe O\nsaid O\nhis O\nfirm O\nwould O\nbe O\nbetter O\noff O\nconcentrating O\non O\nits O\nleading O\nbrand O\n, O\nZywiec B-ORG\nFull B-MISC\nLight I-MISC\n, O\nwhich O\naccounts O\nfor O\n85 O\npercent O\nof O\nsales O\nand O\nis O\nthe O\ncountry O\n's O\nlargest-selling O\nbrand O\n. O\n\n\" O\nYou O\nwill O\nnot O\nwin O\nthe O\nwar O\nof O\nthe O\nPolish B-MISC\nbeer O\nmarket O\nwith O\nimported O\ninternational O\nbrands O\n, O\n\" O\nvan O\nBoxmeer B-PER\nsaid O\n, O\nadding O\nthat O\nHeineken B-ORG\nwould O\nremain O\nan O\nup-market O\nimport O\nin O\nPoland B-LOC\n. O\n\nVan B-PER\nBoxmeer I-PER\nalso O\nsaid O\nZywiec B-ORG\nwould O\nbe O\nboosted O\nby O\nits O\nrecent O\nshedding O\nof O\nsoft O\ndrinks O\nwhich O\nonly O\naccounted O\nfor O\nabout O\nthree O\npercent O\nof O\nthe O\nfirm O\n's O\noverall O\nsales O\nand O\nfor O\nwhich O\n7.6 O\nmillion O\nzlotys O\nin O\nprovisions O\nhad O\nalready O\nbeen O\nmade O\n. O\n\n-- O\nWarsaw B-ORG\nNewsroom I-ORG\n+48 O\n22 O\n653 O\n9700 O\n\n-DOCSTART- O\n\nHAVEL B-PER\nHAS O\nTRAECHEOTOMY O\nAFTER O\nCONDITIONS O\nWORSENS O\n. O\n\nPRAGUE B-LOC\n1996-12-06 O\n\nDoctors O\nperformed O\nan O\nemergency O\ntracheotomy O\nto O\nhelp O\nCzech B-LOC\nPresident O\nVaclav B-PER\nHavel I-PER\nbreathe O\nafter O\ncancer O\nsurgery O\non O\nhis O\nlungs O\nearlier O\nthis O\nweek O\n, O\na O\nspokesman O\nsaid O\non O\nFriday O\n. O\n\nHe O\nsaid O\nthat O\nthe O\nprocedure O\nto O\ninsert O\na O\ndevice O\ninto O\nHavel B-PER\n's O\nthroat O\n, O\ndone O\nafter O\nhis O\nbreathing O\nworsened O\non O\nThursday O\n, O\nhad O\nhelped O\n, O\nand O\nthe O\npresident O\n's O\ncondition O\nsignificantly O\nimproved O\n. O\n\n\" O\nA O\nworsening O\nin O\nthe O\npresident O\n's O\nlung O\nfunctions O\ntook O\nplace O\nyesterday O\n, O\n\" O\npresidential O\nspokesman O\nLadlislav B-PER\nSpacek I-PER\nsaid O\nin O\na O\nstatement O\n. O\n\n\" O\nA O\ntracheotomy O\nwas O\nperformed O\nand O\nsupportive O\nbreathing O\nwas O\ninstalled O\nthrough O\nthe O\nhelp O\nof O\na O\nbreathing O\ndevice O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nAfter O\nthese O\nsteps O\n, O\nthe O\npresident O\n's O\ncondition O\nsignigicantly O\nimproved O\n. O\n\" O\n\nHavel B-PER\nhas O\nbeen O\nrecovering O\nfrom O\nsurgery O\non O\nMonday O\nwhich O\nremoved O\na O\nsmall O\nmalignant O\ntumour O\nand O\nhalf O\nof O\nhis O\nright O\nlung O\n. O\n\nDoctors O\nafter O\nthe O\noperation O\nsaid O\nthat O\nthey O\nhad O\ncaught O\nthe O\ncancer O\nearly O\n, O\nand O\nthat O\nHavel B-PER\ncould O\nfully O\nrecover O\nfrom O\nthe O\nsurgery O\nwithin O\nsix O\nweeks O\n. O\n\nHis O\nspokesman O\nsaid O\non O\nThursday O\nthat O\nHavel B-PER\n, O\n60 O\nand O\na O\nheavy O\nsmoker O\n, O\nhad O\nalso O\ndeveloped O\na O\nslight O\ncase O\nof O\npneumonia O\nin O\nthe O\nleft O\nlung O\n. O\n\n-DOCSTART- O\n\nUK-US B-MISC\nopen O\nskies O\ntalks O\nend O\n, O\nno O\ndate O\nto O\nrestart O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nThe O\nUK B-LOC\nDepartment B-ORG\nof I-ORG\nTransport I-ORG\non O\nFriday O\nsaid O\nthat O\nthe O\nlatest O\nround O\nof O\n\" O\nopen O\nskies O\n\" O\ntalks O\nwith O\nthe O\nU.S. B-LOC\nhad O\nended O\nwith O\nno O\ndeal O\non O\nliberalising O\nthe O\ntransatlantic O\nflight O\nmarket O\nand O\nno O\ndate O\nset O\nfor O\nwhen O\ntalks O\nwould O\nrestart O\n. O\n\nA O\nspokesman O\nfor O\nthe O\nDOT B-ORG\ntold O\nReuters B-ORG\n\" O\nWe O\nhave O\nhad O\ntalks O\ntowards O\nconcluding O\na O\nnew O\nair O\nservice O\nagreement O\nwhich O\nwould O\nproduce O\nliberalisation O\n... O\n\nuseful O\nprogress O\nwas O\nmade O\non O\na O\nnumber O\nof O\nissues O\n, O\nbut O\nnot O\nall O\n. O\n\nNo O\ndate O\nhas O\nbeen O\nset O\nfor O\nfurther O\ntalks O\n. O\n\" O\n\n-DOCSTART- O\n\nTambang B-ORG\nTimah I-ORG\nat O\n$ O\n15.575 O\nin O\nLondon B-LOC\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nPT B-ORG\nTambang I-ORG\nTimah I-ORG\nclosed O\nat O\n$ O\n15.575 O\nper O\nGDR O\nin O\nLondon B-LOC\non O\nFriday O\n. O\n\nIt O\nrecorded O\nthe O\nday O\n's O\nlow O\nof O\n$ O\n15.475 O\nand O\nthe O\nday O\n's O\nhigh O\nof O\n$ O\n15.725 O\n. O\n\nIt O\nclosed O\nat O\n$ O\n15.80 O\non O\nThursday O\n. O\n\nOne O\nGlobal O\nDepository O\nReceipt O\nrepresents O\n10 O\ncommon O\nshares O\n. O\n\n-- O\nJakarta B-LOC\nnewsroom O\n+6221 O\n384-6364 O\n\n-DOCSTART- O\n\nTelkom B-ORG\nat O\n$ O\n35 O\nin O\nLondon B-LOC\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nPT B-ORG\nTelekomunikasi I-ORG\nIndonesia I-ORG\n( O\nTelkom B-ORG\n) O\nclosed O\nat O\n$ O\n35 O\nin O\nLondon B-LOC\non O\nFriday O\n. O\n\nIt O\nrecorded O\nthe O\nday O\n's O\nlow O\nof O\n$ O\n34.475 O\nand O\nthe O\nday O\n's O\nhigh O\nof O\n$ O\n35.375 O\n. O\n\nIts O\nprevious O\nclose O\non O\nThursday O\nas O\n$ O\n35.63 O\n. O\n\nOne O\nADS O\nrepresents O\n20 O\nordinary O\nshares O\n-- O\nJakarta B-LOC\nnewsroom O\n+6221 O\n384-6364 O\n. O\n\n-DOCSTART- O\n\nWoman O\ncharged O\nover O\nN. B-LOC\nIreland I-LOC\narms O\nfind O\n. O\n\nBELFAST B-LOC\n1996-12-06 O\n\nA O\nwoman O\nwas O\ncharged O\non O\nFriday O\nwith O\nterrorist O\noffences O\nafter O\nthree O\nIrish B-ORG\nRepublican I-ORG\nArmy I-ORG\nmortar O\nbombs O\nwere O\nfound O\nin O\na O\nBelfast B-LOC\nhouse O\n, O\npolice O\nsaid O\n. O\n\nPolice O\nsaid O\nthe O\nbombs O\nwere O\nfound O\nhidden O\nwith O\nincendiaries O\nand O\nammunition O\nthat O\nwere O\nblocked O\nup O\nbehind O\na O\nkitchen O\nwall O\n. O\n\nThe O\n35-year-old O\nwoman O\nwas O\ncharged O\nwith O\npossession O\nof O\nexplosives O\nwith O\nintent O\nto O\nendanger O\nlife O\nand O\nmaking O\na O\nhouse O\navailable O\nfor O\nthe O\npurpose O\nof O\nterrorism O\n, O\npolice O\nsaid O\n. O\n\nShe O\nwill O\nappear O\nin O\ncourt O\non O\nSaturday O\n. O\n\nHer O\nname O\nwas O\nnot O\nreleased O\n. O\n\nSecurity O\nforces O\nsaid O\nthe O\nbombs O\nmay O\nhave O\nbeen O\nintended O\nfor O\nuse O\nin O\na O\npre-Christmas O\nbombing O\ncampaign O\nby O\nthe O\nguerrilla O\ngroup O\nthat O\nis O\nbattling O\nto O\noust O\nBritain B-LOC\nfrom O\nNorthern B-LOC\nIreland I-LOC\n. O\n\n-DOCSTART- O\n\nBritain B-LOC\nsets O\nconditions O\nto O\nclear O\nAmerican B-MISC\nalliance O\n. O\n\nEdna B-PER\nFernandes I-PER\n\nLONDON B-LOC\n1996-12-06 O\n\nThe O\nBritish B-MISC\ngovernment O\nwarned O\nFriday O\nthat O\nit O\nwould O\nrefer O\nthe O\nproposed O\ntrans-Atlantic B-MISC\nalliance O\nbetween O\nBritish B-ORG\nAirways I-ORG\nPlc I-ORG\nand O\nAmerican B-ORG\nAirlines I-ORG\nto O\nBritain B-LOC\n's O\nMonopolies B-ORG\nand I-ORG\nMergers I-ORG\nCommission I-ORG\nunless O\nthe O\ncarriers O\ncomplied O\nwith O\na O\nnumber O\nof O\nconditions O\n. O\n\nTrade B-ORG\nand I-ORG\nIndustry I-ORG\nSecretary O\nIan B-PER\nLang I-PER\nadded O\nthat O\neven O\nif O\nthe O\nconditions O\nwere O\nmet O\nby O\nboth O\nairlines O\n, O\nfinal O\nclearance O\nwould O\nhinge O\non O\nan O\nopen O\nskies O\ndeal O\nbetween O\nBritain B-LOC\nand O\nthe O\nUnited B-LOC\nStates I-LOC\nto O\nliberalise O\ntrans-Atlantic B-MISC\nair O\ntraffic O\n, O\nwhich O\nwould O\ncreate O\ngreater O\ncompetition O\non O\nthe O\nroutes O\n. O\n\nLang B-PER\nsaid O\nhe O\nsupported O\nconditions O\nproposed O\nby O\nBritain B-LOC\n's O\nOffice B-ORG\nof I-ORG\nFair I-ORG\nTrading I-ORG\n, O\nwhich O\nwas O\nasked O\nto O\nexamine O\nthe O\ncase O\nlast O\nmonth O\n. O\n\n\" O\nI O\nagree O\n... O\nthat O\nwithout O\nsuitable O\nundertakings O\nthe O\nalliance O\nwould O\nbe O\nlikely O\nto O\nlead O\nto O\na O\nsignificant O\nloss O\nof O\nactual O\nand O\npotential O\npassengers O\n, O\non O\nthose O\nroutes O\nwhere O\nBA B-ORG\nand O\nAA B-ORG\ncurrently O\ncompete O\nand O\nfor O\nall O\npassengers O\non O\nthe O\ntrans-Atlantic B-MISC\nmarket O\nroute O\nbetween O\nthe O\nUK B-LOC\nand O\nU.S. B-LOC\n, O\n\" O\nhe O\nsaid O\n. O\n\nHis O\ncomments O\ncame O\njust O\nminutes O\nafter O\nthe O\nlatest O\nset O\nof O\nopen O\nskies O\ntalks O\nended O\nin O\nLondon B-LOC\nwith O\nno O\ndeal O\nsigned O\n. O\n\nIndustry O\nsources O\nsaid O\nthere O\nwas O\nno O\nnew O\ndate O\nfor O\nfresh O\ntalks O\nand O\nblamed O\nthe O\ndeadlock O\non O\nuncertainty O\nover O\nwhether O\nthe O\nBritish B-MISC\nAirways-American I-MISC\ndeal O\nwould O\nbe O\ncleared O\n. O\n\nThe O\nconditions O\nfor O\nclearance O\nof O\nthe O\nalliance O\nwere O\nthat O\nBritish B-ORG\nAirways I-ORG\nand O\nAmerican B-ORG\ndrop O\n168 O\nslots O\nat O\nLondon B-LOC\nHeathrow I-LOC\nairport O\n, O\nthe O\nbusiest O\nin O\nEurope B-LOC\n. O\n\nAmerican B-ORG\n's O\nparent O\n, O\nAMR B-ORG\nCorp. I-ORG\n, O\nsaid O\nit O\ndid O\nnot O\nview O\nthe O\nterms O\nas O\na O\n\" O\ndeal O\nbreaker O\n. O\n\" O\n\nHowever O\n, O\nit O\ncalled O\nthe O\nconditions O\n\" O\nmore O\nsevere O\n\" O\nthan O\nthose O\nimposed O\nby O\nother O\nregulatory O\nauthorities O\non O\nsimilar O\nairline O\nalliances O\n. O\n\nBritish B-ORG\nAirways I-ORG\n's O\ninitial O\nresponse O\nwas O\nthat O\n\" O\nunconditional O\ndivestiture O\nof O\nslots O\nis O\nunprecedented O\nand O\nif O\ndone O\nit O\nmust O\nbe O\non O\nthe O\nbasis O\nof O\nfair O\nmarket O\nvalue O\n. O\n\" O\n\nIt O\nadded O\nthat O\nit O\nwould O\nbe O\n\" O\nprepared O\nto O\ntake O\nreasonable O\nsteps O\nto O\nassist O\nthe O\nintroduction O\nof O\nadditional O\ncompetition O\n. O\n\" O\n\nThe O\ngovernment O\nalso O\nwants O\nBritish B-ORG\nAirways I-ORG\nto O\ndrop O\na O\nclause O\nin O\nits O\nagreement O\nwith O\nUSAir B-ORG\nthat O\nbars O\nit O\nfrom O\ncompeting O\non O\ntrans-Atlantic B-MISC\nroutes O\n, O\nand O\nsaid O\nboth O\nBritish B-ORG\nAirways I-ORG\nand O\nAmerican B-ORG\nshould O\nbe O\nprepared O\nto O\nreduce O\nservices O\non O\nthe O\nLondon B-LOC\nto O\nDallas-Fort B-LOC\nWorth I-LOC\nroute O\nin O\nthe O\nevent O\nthat O\na O\nnew O\nentrant O\nwishes O\nto O\nenter O\n. O\n\nIt O\nalso O\nsuggested O\nlosing O\nsome O\nslots O\non O\nthe O\nLondon-to-Boston B-MISC\nroute O\n. O\n\nThe O\nOffice B-ORG\nof I-ORG\nFair I-ORG\nTrade I-ORG\ncalled O\nfor O\nBritish B-ORG\nAirways I-ORG\n/ O\nAmerican B-ORG\nto O\nallow O\nthird-party O\naccess O\nto O\ntheir O\njoint O\nfrequent O\nflyer O\nprogramme O\nwhere O\nthe O\napplicant O\ndoes O\nnot O\nhave O\naccess O\nto O\nan O\nequivalent O\nprogramme O\n. O\n\nLang B-PER\nsaid O\nresponses O\nshould O\nbe O\nmade O\nto O\nthe O\nOffice B-ORG\nof I-ORG\nFair I-ORG\nTrading I-ORG\nby O\nJan. O\n10 O\n, O\n1997 O\n. O\n\n-DOCSTART- O\n\nMed O\noil O\nproducts O\nmostly O\nlower O\nas O\nElf B-ORG\nstrike O\nends O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nMediterranean O\noil O\nproducts O\nwere O\nsteady O\nto O\nmostly O\nlower O\non O\nFriday O\nafter O\nElf B-ORG\nrefinery O\nworkers O\nvoted O\nto O\nend O\ntheir O\nnine-day O\nstrike O\n. O\n\nGas O\noil O\nerased O\nThursday O\n's O\ngains O\n, O\nplunging O\n$ O\n5.50 O\na O\ntonne O\nin O\nline O\nwith O\nthe O\nscreen O\n. O\n\nVolume O\nwas O\nvery O\nthin O\nand O\nmarket O\nremained O\nlong O\n, O\nwith O\npremiums O\ndown O\n$ O\n1 O\nat O\nabout O\nhigh O\ncif O\nquotes O\n+$0.50 O\nbasis O\nGenoa B-ORG\n. O\n\" O\n\nThe O\nsharp O\nmoves O\non O\nthe O\nscreen O\nmake O\neveryone O\nnervous O\n, O\n\" O\na O\ntrader O\nsaid O\n. O\n\nTrades O\nwere O\ndiscussed O\nin O\n0.2 O\n, O\n0.5 O\nand O\none O\npercent O\nheating O\noil O\ninto O\nSyria B-LOC\nand O\nLebanon B-LOC\nand O\nthere O\nwere O\nfresh O\ninquiries O\nfrom O\nFrance B-LOC\nand O\nSpain B-LOC\nfor O\nlow O\nsulphur O\ndiesel O\n. O\n\nInterest O\nremains O\nfocussed O\non O\na O\ntender O\nby O\nIndia B-LOC\nfor O\na O\nsecond O\npurchase O\nof O\nhigh O\nspeed O\ndiesel O\nfor O\nJanuary O\ndelivery O\n. O\n\nFuel O\noil O\nlost O\nground O\nsharply O\nwith O\nweaker O\ncrude O\n, O\nbut O\nalso O\nsuffered O\nfrom O\nsome O\npricing O\npressure O\n. O\n\nHigh O\nsulphur O\ncracked O\nfuel O\nlost O\nabout O\n$ O\n3 O\nto O\n$ O\n109-111 O\nfob O\nMed O\nwith O\nseveral O\ncargoes O\nthreatening O\nto O\noverhang O\nthe O\nmarket O\n. O\n\nThe O\nchance O\nof O\nmaterial O\nheading O\nnorth O\n, O\ntalked O\nearlier O\nthis O\nweek O\n, O\nmay O\nbe O\nin O\njeopardy O\nnow O\nsince O\nAmerican B-MISC\nfuel O\noil O\nis O\nexpected O\nto O\nhead O\ntransatlantic O\nfollowing O\noutages O\nat O\ntwo O\ncoking O\nunits O\nin O\nthe O\nU.S B-LOC\n. O\n\nUp O\nto O\n165,000 O\ntonnes O\nof O\nfuel O\nwill O\nhave O\nto O\nfind O\na O\nnew O\nhome O\nand O\nwith O\nthe O\narbitrage O\nfrom O\nthe O\nU.S. B-LOC\nto O\nEurope B-LOC\nopen O\nRotterdam B-LOC\nis O\na O\nprime O\ncandidate O\n. O\n\nLow O\nsulphur O\nprices O\nwere O\nlower O\nwith O\ncif O\nMed O\npegged O\nin O\nthe O\nmid O\nto O\nlow O\n$ O\n140s O\n. O\n\nGasoline O\nprices O\nfell O\nafter O\nstriking O\nElf B-ORG\nrefinery O\nworkers O\nvoted O\nto O\ngo O\nback O\nto O\nwork O\n, O\ntraders O\nsaid O\n. O\n\nBut O\nan O\nopen O\narbitrage O\nto O\nthe O\nU.S. B-LOC\nand O\ntight O\nItalian B-MISC\nsupplies O\nafter O\nElf B-ORG\nscooped O\nup O\nMed O\nmaterial O\nover O\nthe O\nlast O\nweek O\n, O\ncontinued O\nto O\nunderpin O\nprices O\ninto O\nnext O\nweek O\n. O\n\n-DOCSTART- O\n\nNew O\nmeningitis O\nscare O\nhits O\nBritain B-LOC\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nA O\nboy O\nhas O\ndied O\nfrom O\nmeningitis O\nand O\na O\ngirl O\nfrom O\nthe O\nsame O\nschool O\nhas O\ncontracted O\nthe O\ndisease O\nin O\nthe O\nsecond O\nsuch O\nscare O\nto O\nhit O\nBritain B-LOC\nin O\nas O\nmany O\nweeks O\n, O\nhealth O\nauthorities O\nsaid O\non O\nFriday O\n. O\n\nThe O\n16-year-old O\nwho O\nattended O\nSale B-ORG\nGrammar I-ORG\nSchool I-ORG\nin O\nthe O\nnorthern O\nEngland B-LOC\ncity O\nof O\nManchester B-LOC\ndied O\nless O\nthan O\na O\nday O\nafter O\nbecoming O\nill O\n. O\n\nThe O\n15-year-old O\ngirl O\nis O\nalso O\nsuffering O\nfrom O\nthe O\ndisease O\nand O\nhospital O\nofficials O\ndescribed O\nher O\ncondition O\nas O\nserious O\n. O\n\n\" O\nAt O\nthe O\nmoment O\nthere O\nis O\nno O\nevidence O\nthe O\ntwo O\ncases O\nare O\nlinked O\n. O\n\nHowever O\n, O\nwe O\nare O\nassuming O\nthey O\nare O\nas O\na O\nprecaution O\nfor O\nthe O\ntime O\nbeing O\n, O\n\" O\na O\nspokeswoman O\nsaid O\n. O\n\nThe O\nmore O\nthan O\n1,260 O\nstudents O\nat O\nthe O\nschool O\nare O\nbeing O\ngiven O\nantibiotics O\nas O\na O\nprecaution O\n. O\n\nWales B-LOC\ngrappled O\nwith O\nits O\nown O\ncluster O\nof O\nmeningitis O\ncases O\non O\na O\nuniversity O\ncampus O\nin O\nCardiff B-LOC\n. O\n\nAt O\nleast O\ntwo O\npeople O\nhave O\ndied O\nand O\nhundreds O\nhave O\nbeen O\nvaccinated O\nin O\nan O\neffort O\nto O\ncontain O\nthe O\nvirus O\n. O\n\nIn O\nScotland B-LOC\n, O\neight O\npeople O\nhave O\ndied O\nand O\nhundreds O\nmore O\nare O\nfighting O\na O\nwidespread O\nfood-poisoning O\noutbreak O\n. O\n\nA O\nhealth O\nauthority O\nspokeswoman O\nsaid O\n78 O\npeople O\nsuspected O\nof O\nhaving O\nthe O\ndisease O\n, O\nincluding O\n64 O\nconfirmed O\ncases O\n, O\nwere O\nstill O\nbeing O\ntreated O\n. O\n\nThree O\nwere O\nlisted O\nin O\npoor O\ncondition O\n. O\n\nMore O\nthan O\n290 O\npeople O\nhave O\nreported O\nsymptoms O\nin O\nLanarkshire B-LOC\ncounty O\n, O\nthe O\nworst-hit O\narea O\n, O\nsince O\nthe O\noutbreak O\nfirst O\ncame O\nto O\nlight O\nafter O\npeople O\nate O\ntainted O\nmeat O\npies O\nat O\na O\npensioners O\n' O\nlunch O\n. O\n\n-DOCSTART- O\n\nMajor B-PER\n's O\noffice-Conservatives B-MISC\nstill O\nhave O\nmajority O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nBritish B-MISC\nPrime O\nMinister O\nJohn B-PER\nMajor I-PER\n's O\noffice O\nsaid O\non O\nFriday O\nthat O\nrebel O\nConservative B-MISC\nMP O\nSir O\nJohn B-PER\nGorst I-PER\nhad O\nnot O\n\" O\nresigned O\nthe O\nwhip O\n\" O\n( O\nquit O\nthe O\nparliamentary O\nparty O\n) O\nand O\nthe O\ngovernment O\nstill O\nhad O\na O\nmajority O\nin O\nthe O\n651-seat O\nparliament O\n. O\n\n\" O\nHe O\n( O\nGorst B-PER\n) O\nisreserving O\nthe O\nright O\nnot O\nto O\ncooperate O\n, O\nbut O\nhe O\nhas O\nnot O\nresigned O\nthe O\nwhip O\n. O\n\nThe O\ngovernment O\nstill O\nhas O\na O\nmajority O\n, O\n\" O\na O\nspokesman O\nfrom O\nMajor B-PER\n's O\noffice O\nin O\nDowning B-LOC\nStreet I-LOC\nsaid O\n. O\n\nGorst B-PER\n's O\noffice O\nsaid O\nlater O\nthe O\nMP O\nwould O\nnot O\nfeel O\nhimself O\nobliged O\nto O\nvote O\nwith O\nthe O\ngovernment O\n. O\n\nHe O\nsaid O\nat O\none O\npoint O\nduring O\na O\npress O\nconference O\n: O\n\" O\nI O\nhave O\nseen O\nmy O\nwhip O\n( O\nparty O\nmanager O\n) O\nfor O\nnext O\nweek O\nwhich O\n, O\nof O\ncourse O\n, O\ndoes O\nn't O\nmean O\nvery O\nmuch O\nto O\nme O\nnow O\n. O\n\" O\n\nBefore O\nGorst B-PER\n's O\nstatement O\n, O\nMajor B-PER\nhad O\na O\none-seat O\nmajority O\nin O\nthe O\n651-seat O\nHouse B-ORG\nof I-ORG\nCommons I-ORG\nlower O\nhouse O\nof O\nparliament O\n. O\n\nIn O\nhis O\nformal O\nstatement O\n, O\nGorst B-PER\nsaid O\n: O\n\" O\nI O\nam O\ntoday O\nwithdrawing O\nmy O\ncooperation O\nfrom O\nthe O\ngovernment O\nand O\nshall O\nnot O\ntreat O\nthe O\n\" O\nwhip O\n' O\nas O\neither O\na O\nsummons O\nto O\nattend O\nthe O\nHouse B-ORG\nof I-ORG\nCommons I-ORG\nor O\nas O\nplacing O\nme O\nunder O\nany O\nobligation O\nto O\nvote O\nas O\nadvised O\n. O\n\" O\n\nGorst B-PER\nresigned O\nover O\na O\nhospital O\nclosure O\nin O\nhis O\nconstituency O\n. O\n\n-DOCSTART- O\n\nElectronic B-ORG\nData I-ORG\nbags O\nflight O\ndata O\ncontract O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nInformation O\ntechnology O\nfirm O\nElectronic B-ORG\nData I-ORG\nSystems I-ORG\nsaid O\non O\nFriday O\nit O\nhad O\nbagged O\na O\ncontract O\nfor O\nthe O\nfirst O\nair O\ntraffic O\ncontrol O\nproject O\nbeing O\nfunded O\nunder O\nthe O\nPrivate O\nFinance O\nInitiative O\n. O\n\nIn O\na O\nstatement O\n, O\nEDS B-ORG\nsaid O\nthe O\ncontract O\nwould O\nbe O\nin O\nthe O\nregion O\nof O\n50 O\nmillion O\nstg O\n. O\n\nThe O\ncontract O\ninvolved O\nupgrading O\nthe O\nflight O\ndata O\nprocessing O\nsystem O\nat O\nthe O\nOceanic B-LOC\nControl I-LOC\nCentre I-LOC\nin O\nPrestwick B-LOC\nin O\nsouth O\nwest O\nScotland B-LOC\nfor O\nNational B-ORG\nAir I-ORG\nTraffic I-ORG\nServices I-ORG\nLtd I-ORG\n( O\nNATS B-ORG\n) O\n, O\nsubsidiary O\nof O\nthe O\nCivil B-ORG\nAviation I-ORG\nAuthority I-ORG\n. O\n\nThe O\nsystem O\nis O\nresponsible O\nfor O\nthe O\ncontrol O\nof O\naircraft O\nflying O\ntransatlantic O\nroutes O\nfrom O\nEurope B-LOC\nand O\nNorth B-LOC\nAmerica I-LOC\n. O\n\nThe O\nsystem O\n, O\nwhich O\nwould O\nuse O\nsatellite O\ntechnology O\n, O\nis O\nscheduled O\nto O\nenter O\nservice O\nin O\n2000 O\n. O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+44-171-542 O\n7717 O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nCricket O\n- O\nPlay O\nrestarts O\nin O\nAustralia-West B-MISC\nIndies I-MISC\nmatch O\n. O\n\nMELBOURNE B-LOC\n1996-12-06 O\n\nPlay O\nrestarted O\nin O\nthe O\nfirst O\nWorld B-MISC\nSeries I-MISC\nlimited O\novers O\nmatch O\nbetween O\nWest B-LOC\nIndies I-LOC\nand O\nAustralia B-LOC\nafter O\na O\nrain O\ndelay O\nof O\n50 O\nminutes O\non O\nFriday O\n. O\n\nWest B-LOC\nIndies I-LOC\nresumed O\ntheir O\ninnings O\non O\n53 O\nfor O\ntwo O\nwith O\nopener O\nSherwin B-PER\nCampbell I-PER\non O\n25 O\nand O\nShivnarine B-PER\nChanderpaul I-PER\n10 O\n. O\n\nRain O\nearlier O\ndelayed O\nthe O\nstart O\nof O\nplay O\nby O\n30 O\nminutes O\n. O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373-1800 O\n\n-DOCSTART- O\n\nCricket O\n- O\nPakistan B-LOC\nbeat O\nNew B-LOC\nZealand I-LOC\nby O\n46 O\nruns O\n. O\n\nSIALKOT B-LOC\n, O\nPakistan B-LOC\n1996-12-06 O\n\nPakistan B-LOC\nbeat O\nNew B-LOC\nZealand I-LOC\nby O\n46 O\nruns O\non O\nFriday O\nto O\ntake O\nan O\nunbeatable O\n2-0 O\nlead O\nin O\nthe O\nthree-match O\none-day O\nseries O\n. O\n\nScores O\n: O\nPakistan B-LOC\n277-9 O\n, O\nNew B-LOC\nZealand I-LOC\n231 O\n\n-DOCSTART- O\n\nManitoba B-ORG\nPork I-ORG\nforward O\ncontract O\nPM O\nprices O\n- O\nDec O\n6 O\n. O\n\nWINNIPEG B-LOC\n1996-12-06 O\n\nManitoba B-ORG\nPork I-ORG\nclosing O\nforward O\ncontract O\nprices O\nin O\nCanadian B-MISC\ndollars O\nper O\nhundred O\nlbs O\n( O\nCwt O\n) O\nfor O\nDec O\n6 O\nincluding O\nminimum O\nguaranteed O\nprice O\n-- O\n\nCONTRACT O\nPREVIOUS O\nCLOSE O\nPM O\nCLOSE O\nPM O\nCLOSING O\nRANGE O\n\nDATE O\nPM O\nCLOSE O\nFIXED O\nMINIMUM O\nAT O\n1230 O\nCST O\n\nFeb O\n97 O\n79.94 O\n79.67 O\n75.55 O\n77.01-81.80 O\n\nMar O\n97 O\n76.37 O\n76.12 O\n72.02 O\n73.47-78.24 O\n\nApr O\n97 O\n74.13 O\n74.69 O\n70.59 O\n72.04-76.81 O\n\nMay O\n97 O\n76.51 O\n77.07 O\n72.97 O\n74.42-79.19 O\n\nJun O\n97 O\n77.53 O\n77.24 O\n73.17 O\n74.62-79.35 O\n\nJul O\n97 O\n74.45 O\n74.01 O\n69.95 O\n71.39-76.12 O\n\nAug O\n97 O\n72.41 O\n72.07 O\n68.01 O\n69.45-74.18 O\n\nSep O\n97 O\n69.18 O\n69.24 O\n65.17 O\n66.61-71.34 O\n\nOct O\n97 O\n68.00 O\n68.05 O\n63.98 O\n65.43-70.16 O\n\nNov O\n97 O\n68.00 O\n68.05 O\n63.98 O\n65.43-70.16 O\n\nNote O\n: O\nManitoba B-ORG\nGovernment O\nPrice O\nIndex O\n( O\nC$ B-MISC\nper O\ncwt O\n) O\n- O\n\nDec O\n4 O\n87.16 O\n\nManitoba B-ORG\n's O\nHog O\nPrice O\nRange O\n: O\n84.00-86.00 O\nper O\ncwt O\n\nCAN B-LOC\n/ O\nU.S. B-LOC\nDOLLAR O\nEXCHANGE O\nRATE O\n: O\n1.3570 O\n\nSource O\n: O\nManitoba B-ORG\nPork I-ORG\n. O\n\n( O\n( O\nWinnipeg B-LOC\nbureau O\n204-947-3548 O\n) O\n) O\n\n-DOCSTART- O\n\nCanadian B-MISC\nWest O\nCoast O\nVessel O\nLoadings O\n- O\nCWB O\n. O\n\nWINNIPEG B-LOC\n1996-12-06 O\n\nThe O\nCanadian B-ORG\nWheat I-ORG\nBoard I-ORG\nreported O\nsix O\nships O\nloading O\n, O\n10 O\nwaiting O\nand O\nfour O\ndue O\nat O\nthe O\nCanadian B-MISC\nWest O\nCoast O\n, O\nas O\nof O\nFriday O\n. O\n\nThe O\nlongest O\nwait O\nto O\nload O\non O\nthe O\nWest O\nCoast O\nwas O\n13 O\ndays O\n. O\n\nTwo O\nship O\nloaded O\nin O\nThunder B-LOC\nBay I-LOC\n, O\none O\nwaited O\nand O\nseven O\nwere O\ndue O\n. O\n\nTwo O\nships O\nloaded O\non O\nthe O\nEast O\nCoast O\n, O\nthree O\nwaited O\nto O\nload O\n, O\nsix O\nwere O\ndue O\n. O\n\nPort O\nLoading O\nWaiting O\n\nVancouver B-LOC\n5 O\n7 O\n\nPrince B-LOC\nRupert I-LOC\n1 O\n3 O\n\n( O\n( O\nGilbert B-PER\nLe I-PER\nGras I-PER\n204 O\n947 O\n3548 O\n) O\n) O\n\n-DOCSTART- O\n\nNew B-LOC\nYork I-LOC\ntimecharter O\nfixtures O\n- O\nDec O\n6 O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nNo O\nnew O\nfixtures O\nreported O\nfrom O\nNew B-LOC\nYork I-LOC\n. O\n\n-- O\nNew B-ORG\nYork I-ORG\nCommodities I-ORG\nDesk I-ORG\n+1 O\n212 O\n859 O\n1640 O\n\n-DOCSTART- O\n\nNew B-LOC\nYork I-LOC\ncoal O\n/ O\nore O\n/ O\nscrap O\nfixtures O\n- O\nDec O\n6 O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nORE O\n- O\nMaritime B-MISC\nQueen I-MISC\n70,000 O\ntonnes O\nDampier B-LOC\n/ O\nKaohsiung B-LOC\n20-30/12 O\n$ O\n5.25 O\nfio O\n35,000 O\n/ O\n30,000 O\nChina B-ORG\nSteel I-ORG\n. O\n\n-- O\nNew B-ORG\nYork I-ORG\nCommodities I-ORG\nDesk O\n+1 O\n212 O\n859 O\n1640 O\n\n-DOCSTART- O\n\nClean O\ntankers O\nfixtures O\nand O\nenquiries O\n- O\n2321 O\nGMT B-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nFIXTURES O\n- O\n\nWESTERN O\nHEMISPHERE O\n- O\n\nDanila B-MISC\n28.5 O\n16/12 O\nCaribs B-LOC\n/ O\nup O\nW224 O\nMobil B-ORG\n. O\n\n-- O\nNew B-ORG\nYork I-ORG\nCommodities I-ORG\nDesk O\n, O\n212-859-1640 O\n\n-DOCSTART- O\n\nDirty O\ntanker O\nfixtures O\nand O\nenquiries O\n- O\n2317 O\nGMT B-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nMIDEAST O\n/ O\nRED B-LOC\nSEA I-LOC\n- O\n\nThai B-MISC\nResource I-MISC\n264 O\n31/12 O\nRas B-LOC\nTanura I-LOC\n/ O\nRed B-LOC\nSea I-LOC\nW46.50 O\nMobil B-ORG\n. O\n\nMEDITERRANEAN B-MISC\n- O\n\nLula B-MISC\nI I-MISC\n85 O\n25/12 O\nSidi B-LOC\nKreir I-LOC\n/ O\nAugusta B-LOC\nW100 O\nExxon B-ORG\n. O\n\nSpetses B-MISC\n139 O\n17/12 O\nSidi B-LOC\nKreir I-LOC\n/ O\nAugusta B-LOC\nW97.50 O\nExxon B-ORG\n. O\n\nMesipia B-MISC\n77.5 O\n17/12 O\nBajaia B-LOC\n/ O\nFos B-LOC\nW105 O\nExxon B-ORG\n. O\n\n-- O\nNew B-ORG\nYork I-ORG\nCommodities I-ORG\nDesk I-ORG\n+1 O\n212 O\n859 O\n1640 O\n\n-DOCSTART- O\n\nNYC B-MISC\nJan O\nrefunding O\nhas O\nits O\n1st O\nEuro B-MISC\nfloating O\nrate O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nNew B-LOC\nYork I-LOC\nCity I-LOC\non O\nFriday O\nsaid O\nthat O\nit O\nplanned O\na O\n$ O\n775 O\nmillion O\nrefunding O\nfor O\nJanuary O\nthat O\nwill O\ninclude O\nits O\nfirst O\nfloating O\nrate O\nissue O\nof O\ntaxable O\ndebt O\nfor O\nEuropean B-MISC\ninvestors O\n. O\n\nA O\ncity O\nofficial O\n, O\nwho O\ndeclined O\nto O\nbe O\nnamed O\n, O\nexplained O\nthat O\nGoldman B-ORG\n, I-ORG\nSachs I-ORG\n, O\nwhich O\nthis O\nsummer O\nwas O\ndemoted O\nto O\nthe O\nsecond O\ntier O\nof O\nthe O\nsyndicate O\n, O\nproposed O\nthe O\nfloating O\nrate O\nissue O\nand O\nas O\na O\nresult O\nwas O\npromoted O\nto O\nbook O\nrunner O\nfor O\nthis O\noffering O\n. O\n\nBy O\nselling O\nthe O\nfloating O\nrate O\ndebt O\n, O\nthe O\ncity O\nhopes O\nto O\nestablish O\na O\nbenchmark O\n, O\nthe O\ncity O\nofficial O\nsaid O\n, O\nadding O\nthat O\nit O\nneeded O\na O\nlarge O\ndeal O\nto O\naccomplish O\nthis O\nobjective O\n. O\n\nThe O\ncity O\nin O\nlate O\nJune O\nsold O\nits O\nfirst O\nissue O\nof O\nEuronotes B-MISC\n, O\na O\nstrategy O\nthat O\nit O\nsays O\nsaved O\nit O\n$ O\n500,000 O\nin O\ninterest O\ncosts O\n, O\nand O\nit O\nhas O\nbeen O\ntrying O\nto O\nbuild O\non O\nthis O\nstrategy O\nof O\nexpanding O\nthe O\npool O\nof O\npotential O\ninvestors O\nsince O\nthen O\n. O\n\nIn O\nNovember O\n, O\nNew B-LOC\nYork I-LOC\nCity I-LOC\nsaid O\nit O\nbecame O\nthe O\nfirst O\nU.S. B-LOC\nmunicipality O\nto O\noffer O\nbonds O\nfor O\nsale O\nin O\nEuropean B-MISC\nmarkets O\nby O\ncompetitive O\nbidding O\nas O\nit O\nlisted O\ntaxable O\nbonds O\non O\nthe O\nLondon B-ORG\nStock I-ORG\nExchange I-ORG\n. O\n\nThe O\nrefunding O\nplanned O\nfor O\nJanuary O\nalso O\nincludes O\na O\n$ O\n475 O\nmillion O\ntax-exempt O\noffering O\n. O\n\nNo O\nspecific O\ndate O\nin O\nJanuary O\nhas O\nbeen O\nselected O\nfor O\nthe O\ndebt O\nsale O\n, O\nthe O\nofficial O\nadded O\n. O\n\n-- O\nJoan B-PER\nGralla I-PER\n, O\n212-859-1654 O\n\n-DOCSTART- O\n\nUSDA B-ORG\ngross O\ncutout O\nhide O\nand O\noffal O\nvalue O\n. O\n\nDES B-LOC\nMOINES I-LOC\n1996-12-06 O\n\nThe O\nhide O\nand O\noffal O\nvalue O\nfrom O\na O\ntypical O\nslaughter O\nsteer O\nfor O\nFriday O\nwas O\nestimated O\nat O\n$ O\n9.54 O\nper O\ncwt O\nlive O\n, O\ndn O\n0.05 O\nwhen O\ncompared O\nto O\nThursday O\n's O\nvalue O\n. O\n\n- O\nUSDA B-ORG\n\n-DOCSTART- O\n\nWall B-LOC\nSt I-LOC\nspeculates O\nabout O\nSanta B-LOC\nFe I-LOC\nsavior O\n. O\n\nBrendan B-PER\nIntindola I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nHomestake B-ORG\nMining I-ORG\nCo I-ORG\ntops O\nWall B-LOC\nStreet I-LOC\n's O\nlist O\nas O\nthe O\nmost O\nlikely O\nwhite O\nknight O\nbuyer O\nfor O\nSanta B-ORG\nFe I-ORG\nPacific I-ORG\nGold I-ORG\nCorp I-ORG\nif O\nSanta B-ORG\nFe I-ORG\nrejects O\nunsolicited O\nsuitor O\nNewmont B-ORG\nMining I-ORG\nCorp I-ORG\n. O\n\nSanta B-ORG\nFe I-ORG\nis O\nso O\nfar O\nmum O\non O\nthe O\nmore O\nthan O\n$ O\n2 O\nbillion O\nstock O\nswap O\ntakeover O\nproposal O\nfrom O\nNewmont B-ORG\n, O\nannounced O\nThursday O\n. O\n\nWall B-LOC\nStreet I-LOC\n, O\nsince O\nthe O\nbid O\n, O\nhas O\nspeculated O\nthat O\nany O\ndeal O\nbetween O\nNewmont B-ORG\nand O\nSanta B-ORG\nFe I-ORG\nwould O\nbe O\na O\n\" O\nbear O\nhug O\n, O\n\" O\nor O\na O\nreluctantly O\nnegotiated O\nagreement O\nwhere O\nthe O\nbuyer O\nis O\nnot O\nnecessarily O\na O\nfriendly O\nsuitor O\n. O\n\nNewmont B-ORG\nsaid O\nthe O\ncompanies O\nhave O\nhad O\nprevious O\ncontact O\n, O\nthough O\ndeclined O\nto O\ndetail O\nthe O\nencounters O\n. O\n\nAnalysts O\npredict O\nSanta B-ORG\nFe I-ORG\nwill O\ngo O\nto O\nthe O\nhighest O\nbidder O\n, O\nand O\nthat O\nif O\na O\nrival O\nbuyer O\nis O\nfound O\n, O\nNewmont B-ORG\nmay O\nnot O\nbe O\nable O\nto O\nmatch O\nits O\noffer O\n. O\n\nThey O\nsaid O\nthe O\nSanta B-ORG\nFe I-ORG\ndeal O\n, O\nwhich O\nincludes O\ndesirable O\nNevada B-LOC\nmining O\nterritory O\n, O\nwould O\nonly O\npayoff O\nfor O\nNewmont B-ORG\nlonger O\nterm O\n. O\n\nNewmont B-ORG\n, O\nin O\nfact O\n, O\nwill O\nnot O\nbenefit O\nfrom O\nthe O\nSanta B-ORG\nFe I-ORG\nacquisition O\non O\nan O\nearnings O\nbasis O\nfor O\nat O\nleast O\ntwo O\nyears O\n, O\nwhich O\nalso O\nlimits O\nits O\ncapacity O\nto O\nraise O\nits O\noffer O\n. O\n\nAny O\ndeal O\n, O\nfriendly O\nor O\nhostile O\n, O\nwould O\nalmost O\nassuredly O\nbe O\na O\nstock O\nswap O\n, O\nwhich O\nis O\nnecessary O\nto O\npreserve O\nthe O\ntax-free O\n, O\npooling-of-interest O\naccounting O\n, O\nthey O\nsaid O\n. O\n\nAnalysts O\nand O\narbitrageurs O\nimmediately O\nruled O\nout O\nBarrick B-ORG\nGold I-ORG\nCorp I-ORG\nand O\nBre-X B-ORG\nMinerals I-ORG\nLtd I-ORG\nas O\nSanta B-ORG\nFe I-ORG\nsaviors O\nbecause O\nthey O\nare O\nlocked O\nin O\nnegotiations O\nover O\ntheir O\nsplitting O\nIndonesia B-LOC\n's O\nBusang B-ORG\nvast O\ngold O\ndeposit O\n. O\n\nPlacer B-ORG\nDome I-ORG\nInc I-ORG\ntoo O\nwas O\nconsidered O\nunlikley O\nbecause O\nit O\nis O\nfocusing O\non O\ngeographic O\nexpansion O\nin O\nareas O\nthat O\ndo O\nmatch O\nSanta B-ORG\nFe I-ORG\n's O\nNevada B-LOC\n, O\nSouth B-LOC\nAmerica I-LOC\nand O\nCentral B-LOC\nAsia I-LOC\npresence O\n, O\nthey O\nsaid O\n. O\n\nA O\nHomestake B-ORG\nspokesman O\nwas O\nnot O\nimmediately O\navailable O\nto O\ncomment O\non O\nspeculation O\nthat O\nit O\ntops O\nthe O\nlist O\n. O\n\nHomestake B-ORG\n, O\nbased O\nin O\nSan B-LOC\nFrancisco I-LOC\n, O\noperates O\ngold O\nmines O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\n, O\nAustralia B-LOC\n, O\nChile B-LOC\nand O\nCanada B-LOC\n. O\n\nEarnings O\nin O\n1995 O\nwere O\n$ O\n0.22 O\nper O\nshare O\n, O\nor O\n$ O\n30.3 O\nmillion O\n, O\non O\nrevenues O\nof O\n$ O\n746.3 O\nmillion O\n. O\n\nSanta B-ORG\nFe I-ORG\nis O\nheadquartered O\nAlbuquerque B-LOC\n, O\nN.M. B-LOC\nand O\nreported O\n1995 O\nearnings O\nof O\n$ O\n0.30 O\nper O\nshare O\n, O\nor O\n$ O\n40 O\nmillion O\n, O\non O\nrevenues O\nof O\n$ O\n350 O\nmillion O\n. O\n\nSanta B-ORG\nFe I-ORG\nhas O\nmining O\nand O\nexploration O\noperations O\nin O\nNevada B-LOC\n, O\nCalifornia B-LOC\n, O\nMontana B-LOC\n, O\nCanada B-LOC\n, O\nBrazil B-LOC\n, O\nAustralia B-LOC\n, O\nChile B-LOC\n, O\nKazakstan B-LOC\n, O\nMexico B-LOC\nand O\nGhana B-LOC\n. O\n\nPaineWebber B-ORG\nanalyst O\nMarc B-PER\nCohen I-PER\nsaid O\nhe O\nlowered O\nhis O\nrating O\non O\nNewmont B-ORG\nto O\nneutral O\nfrom O\nattractive O\ntoday O\nbecause O\nif O\nNewmont B-ORG\nmerged O\nwith O\nSanta B-ORG\nFe I-ORG\n, O\ninvestors O\nwould O\nhave O\nto O\nwait O\nuntil O\nthe O\nsecond O\nhalf O\nof O\n1998 O\nto O\nrealize O\nearnings O\naccretion O\n. O\n\n\" O\nI O\nthink O\nHomestake B-ORG\ncould O\ncome O\nin O\nas O\na O\nwhite O\nknight O\n, O\nbut O\nhow O\nmuch O\nis O\nsomeone O\nwilling O\nto O\ncome O\nin O\nabove O\nthe O\nNewmont B-ORG\nnumber O\n. O\n\nOne O\nwould O\nhave O\nto O\noutbid O\nby O\nat O\nleast O\n15 O\npercent O\n, O\nbut O\nthere O\nis O\ngoing O\nto O\nbe O\na O\n( O\nSanta B-ORG\nFe I-ORG\n) O\ndeal O\nwith O\nsomeone O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nLonger O\nterm O\n, O\ntwo O\nto O\nthree O\nyears O\nout O\n, O\n( O\na O\nNewmont-Santa B-MISC\nFe I-MISC\ndeal O\n) O\nis O\npositive O\n, O\nit O\ndoes O\nall O\nthe O\nright O\nthings O\n. O\n\nBut O\nin O\nthe O\nnear-term O\nit O\nis O\n, O\nat O\nworst O\n, O\nneutral O\n, O\n\" O\nthe O\nanalyst O\nadded O\n. O\n\nNewmont B-ORG\nproposed O\nto O\nSanta B-LOC\nFe I-LOC\na O\nstock-swap O\nmerger O\nat O\na O\nratio O\nof O\n0.33 O\nNewmont B-ORG\nshares O\nfor O\neach O\nSanta B-ORG\nFe I-ORG\nshares O\n. O\n\nIn O\nFriday O\nNew B-ORG\nYork I-ORG\nStock I-ORG\nExchange I-ORG\ntrade O\n, O\nNewmonth B-ORG\nwas O\noff O\n1/2 O\nto O\n46-5/8 O\nwhile O\nSanta B-ORG\nFe I-ORG\nadded O\n1/4 O\nto O\n15-1/8 O\n. O\n\n\" O\nNewmont B-ORG\nsaid O\nit O\nwants O\nto O\ndiscuss O\na O\nfriendly O\ndeal O\nwith O\nSanta B-ORG\nFe I-ORG\n, O\nwhich O\nis O\nalmost O\nalways O\na O\neuphemism O\nfor O\n' O\nWe O\nhave O\nmore O\nmoney O\nin O\nour O\npocket O\n, O\n' O\n\" O\nsaid O\nan O\narb O\n, O\nreferring O\nto O\na O\npossible O\nsweetened O\nbid O\nfrom O\nNewmont B-ORG\n. O\n\nTwo O\nother O\narbs O\ncalled O\nNewmont B-ORG\n's O\nmove O\na O\n\" O\na O\n32 O\ncent O\nbid O\n\" O\nbecause O\nthere O\nis O\nno O\nformal O\ntender O\noffer O\n, O\nonly O\nthe O\nproposal O\nletter O\n\" O\nmailed O\n\" O\nto O\nSanta B-ORG\nFe I-ORG\n's O\nboard O\n. O\n\n-- O\nWall B-ORG\nStreet I-ORG\nDesk I-ORG\n, O\n212-859-1734 O\n. O\n\n-DOCSTART- O\n\nRuss B-ORG\nBerrie I-ORG\npresident O\nto O\nretire O\nin O\nJuly O\n. O\n\nOAKLAND B-LOC\n, O\nN.J. B-LOC\n1996-12-06 O\n\nRuss B-ORG\nBerrie I-ORG\nand I-ORG\nCo I-ORG\nInc I-ORG\nsaid O\non O\nFriday O\nthat O\nA. B-PER\nCurts I-PER\nCooke I-PER\nwill O\nretire O\nas O\npresident O\nand O\nchief O\noperating O\nofficer O\neffective O\nJuly O\n1 O\n, O\n1997 O\n. O\n\nCooke B-PER\nwill O\nprovide O\nconsulting O\nservices O\nto O\nthe O\ncompany O\nthrough O\nJuly O\n1 O\n, O\n1998 O\n, O\nand O\nwill O\ncontinue O\nto O\nserve O\nas O\na O\ndirector O\n, O\nthe O\ntoy O\nand O\ngift O\nmaker O\nsaid O\n. O\n\n-DOCSTART- O\n\nZimbabwe B-LOC\nexecutes O\nconvicted O\nmurderer O\n. O\n\nHARARE B-LOC\n1996-12-06 O\n\nZimbabwe B-LOC\nhanged O\na O\nconvicted O\nmurderer O\non O\nFriday O\n, O\nbringing O\nto O\neight O\nthe O\nnumber O\nof O\nexecutions O\ncarried O\nout O\nin O\nthe O\npast O\nyear O\n. O\n\nA O\nstatement O\nsaid O\nPiniel B-PER\nSindiso I-PER\nNcube I-PER\nwas O\nhanged O\nat O\ndawn O\n. O\n\nPresident O\nRobert B-PER\nMugabe I-PER\n's O\ngovernment O\nhas O\nresisted O\npressure O\nfrom O\nlocal O\nand O\ninternational O\nhuman O\nrights O\ngroups O\nto O\nabolish O\nthe O\ndeath O\nsentence O\n. O\n\n-DOCSTART- O\n\nMultinational O\ncommander O\ngoing O\nback O\nto O\neast O\nZaire B-LOC\n. O\n\nJonathan B-PER\nWright I-PER\n\nNAIROBI B-LOC\n1996-12-06 O\n\nThe O\nCanadian B-MISC\ngeneral O\nin O\ncharge O\nof O\na O\nmultinational O\nforce O\nfor O\neastern O\nZaire B-LOC\nsaid O\non O\nFriday O\nhe O\nwas O\ngoing O\nback O\nto O\nZaire B-LOC\nfor O\nmore O\ninformation O\nabout O\nthe O\nplight O\nof O\nabout O\n165,000 O\nRwandan B-MISC\nrefugees O\nadrift O\nin O\nthe O\ncountryside O\n. O\n\nLieutenant-General O\nMaurice B-PER\nBaril I-PER\ntold O\na O\nnews O\nconference O\nin O\nNairobi B-LOC\nhis O\nmain O\nconcern O\nwas O\nfor O\na O\nlarge O\ngroup O\nof O\nabout O\n150,000 O\nrefugees O\nliving O\noff O\nthe O\nland O\nin O\na O\nvalley O\nabout O\n65 O\nkm O\n( O\n40 O\nmiles O\n) O\nwest O\nof O\nthe O\neastern O\ncity O\nof O\nGoma B-LOC\n. O\n\nIf O\nhe O\ndecided O\nit O\nwas O\nnecessary O\nand O\nsafe O\nfor O\nthe O\naircrew O\n, O\nhe O\nwould O\nnot O\nhesitate O\nto O\norder O\nairdrops O\nof O\nfood O\nfor O\nthe O\nrefugees O\n, O\neven O\nagainst O\nthe O\nwishes O\nof O\nthe O\ngovernment O\nin O\nKinshasa B-LOC\nand O\nthe O\nZairean B-MISC\nrebels O\nwho O\ncontrol O\nmuch O\nof O\neastern O\nZaire B-LOC\n, O\nhe O\nsaid O\n. O\n\n\" O\nTomorrow O\nI O\n'm O\ngoing O\ninto O\nRwanda B-LOC\nand O\nmy O\nintention O\nis O\nto O\ngo O\nacross O\ninto O\neastern O\nZaire B-LOC\nand O\ntry O\nto O\nfind O\nout O\nfor O\nthe O\nsecond O\ntime O\nwhat O\nthe O\nsituation O\nis O\non O\nthe O\nground O\n, O\n\" O\nhe O\nsaid O\n. O\n\nGeneral O\nBaril B-PER\nsaw O\nrebel O\nleader O\nLaurent B-PER\nKabila I-PER\nin O\nGoma B-LOC\nlast O\nweek O\nbut O\nthe O\nrebels O\ntold O\nhim O\nthe O\ncrisis O\nwas O\nover O\nbecause O\nmost O\nof O\nthe O\nRwandan B-MISC\nrefugees O\nhave O\nalready O\ngone O\nhome O\n. O\n\nThe O\nrebels O\ndo O\nnot O\nwant O\nthe O\nmultinational O\nforce O\nto O\ndeploy O\non O\nthe O\nground O\n, O\nfor O\nfear O\nit O\nmight O\nhelp O\nthe O\nZairean B-MISC\narmy O\nregain O\ncontrol O\nof O\nthe O\narea O\n. O\n\nKinshasa B-LOC\nopposes O\nairdrops O\n, O\napparently O\nbecause O\nthe O\nfood O\ncould O\nfall O\ninto O\nthe O\nhands O\nof O\nthe O\nrebels O\nand O\ntheir O\nlocal O\nsupporters O\n. O\n\nCanadian B-MISC\nDefence O\nMinister O\nDoug B-PER\nYoung I-PER\nsaid O\non O\nThursday O\nthat O\nthe O\nmultinational O\nforce O\nwould O\nprobably O\nnot O\nhave O\nto O\nmake O\nfood O\nairdrops O\nor O\nintervene O\nmilitarily O\nin O\nany O\nmajor O\nway O\n. O\n\n\" O\nIt O\ndoes O\nn't O\nlook O\nas O\nthough O\nthey O\n( O\nairdrops O\n) O\nare O\ngoing O\nto O\nbe O\nrequired O\nin O\nany O\nsignificant O\nway O\nbecause O\nthe O\nNGOs O\n( O\nnon-governmental O\norganisations O\n) O\nare O\nin O\nthat O\narea O\non O\nthe O\nborder O\nbetween O\nZaire B-LOC\nand O\nRwanda B-LOC\n, O\n\" O\nYoung B-PER\ntold O\nreporters O\n. O\n\nBut O\nGeneral O\nBaril B-PER\nsaid O\nit O\nwould O\nbe O\npremature O\nto O\nrule O\nout O\nany O\ncourse O\nof O\naction O\nuntil O\nhe O\nhad O\nmore O\ninformation O\n. O\n\n\" O\nWe O\nhope O\nthat O\nif O\nthe O\nfront O\nmoves O\nforward O\nor O\nstabilises O\nthen O\nwe O\nwill O\nhave O\naccess O\n( O\nto O\nthe O\nlarge O\ngroup O\nof O\nrefugees O\n) O\nwith O\nreconnaissance O\nor O\nhumanitarian O\nagencies O\n. O\n\n\" O\nIf O\nthey O\nca O\nn't O\nmove O\nbecause O\nthey O\nare O\ntoo O\nweak O\n, O\nthen O\nwe O\nwill O\nprobably O\nconsider O\nvery O\nseriously O\nusing O\nair O\ndelivery O\nmeans O\n( O\nairdrops O\n) O\n...It O\n's O\ncomplex O\n, O\nit O\n's O\ndangerous O\nfor O\nthe O\nair O\ncrew O\nthat O\nfly O\nin O\nthere O\nand O\nit O\nwill O\nhave O\nto O\nbe O\nabsolutely O\nnecessary O\n. O\n\nIf O\nit O\nis O\nnecessary O\n, O\nI O\nwo O\nn't O\nhesitate O\nto O\nuse O\nit O\n, O\n\" O\nhe O\nsaid O\n. O\n\nAsked O\nif O\nhe O\nwould O\ndisregard O\nthe O\nobjections O\nof O\nthe O\nZairean B-MISC\ngovernment O\n, O\nhe O\nsaid O\n: O\n\" O\nIt O\nwould O\nhave O\nto O\nbe O\nin O\nthe O\nlast O\nresort O\n. O\n\nIt O\nwould O\nhave O\nto O\nmean O\nthat O\ntens O\nof O\nthousands O\nof O\nlives O\nare O\nin O\ndanger O\n. O\n\nDo O\nyou O\nthink O\nthat O\nI O\nwould O\nhave O\na O\nconscience O\nproblem O\ndoing O\nit O\nor O\nnot O\nat O\nthat O\ntime O\n? O\n\nAnd O\nmy O\nmandate O\nis O\nalso O\nunder O\nChapter O\nSeven O\nto O\noperate O\nin O\neastern O\nZaire B-LOC\n. O\n\" O\n\nUnder O\nChapter O\nSeven O\nof O\nthe O\nU.N. B-ORG\ncharter O\n, O\nthe O\nSecurity B-ORG\nCouncil I-ORG\nhas O\nwide O\npowers O\nto O\npreserve O\npeace O\nand O\nsecurity O\n. O\n\n\" O\nI O\nknow O\ntheir O\n( O\nthe O\nZairean B-MISC\ngovernment O\n's O\n) O\nposition O\nand O\nI O\nknow O\nit O\n's O\nvery O\ndelicate O\nand O\nwe O\nare O\nvery O\nsensitive O\nto O\ntheir O\nposition O\nalso O\n, O\n\" O\nthe O\ngeneral O\nadded O\n. O\n\nHe O\ndenied O\nthat O\nhis O\ncontacts O\n, O\ncriticised O\nby O\nKinshasa B-LOC\n, O\nwith O\nthe O\nZairean B-MISC\nrebels O\namounted O\nto O\nnegotiations O\n. O\n\n\" O\nI O\ndo O\nn't O\nnegotiate O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nI O\ncoordinate O\nwith O\nthose O\nwho O\nare O\nholding O\nground O\nand O\nthat O\n's O\na O\nwise O\nthing O\nto O\ndo O\n. O\n\nWhen O\nwe O\ndo O\nn't O\nknow O\nwhere O\nthe O\nfront O\nis O\n, O\nwe O\ndo O\nn't O\nknow O\nwhat O\nthe O\nrisk O\nis O\n. O\n\" O\n\nBaril B-PER\nsaid O\nthat O\napart O\nfrom O\nthe O\ngroup O\nof O\n150,000 O\n, O\nU.S. B-LOC\nand O\nBritish B-MISC\nreconnaissance O\nplans O\nhad O\ntracked O\ntwo O\nmuch O\nsmaller O\ngroups O\nof O\nrefugees O\n-- O\none O\nof O\nup O\nto O\n1,000 O\nnorth O\nof O\nthe O\ntown O\nof O\nMasisi O\nand O\none O\nof O\nup O\nto O\n8,000 O\non O\nthe O\nroad O\nfrom O\nBukavu B-LOC\nwest O\nto O\nKindu B-LOC\n. O\n\nThe O\nKisangani B-LOC\noffice O\nof O\nthe O\nmedical O\ncharity O\nMedecins B-ORG\nsans I-ORG\nFrontieres I-ORG\nsaid O\non O\nFriday O\nthat O\nmore O\nthan O\n100,000 O\nrefugees O\nwere O\ntrekking O\nnorthwest O\nfrom O\nthe O\nGoma-Bukavu B-LOC\narea O\nand O\nmany O\nof O\nthem O\nwere O\nnow O\nin O\nthe O\ntown O\nof O\nWalikale B-LOC\n. O\n\nThe O\ngeneral O\ndid O\nnot O\nmention O\nthese O\nrefugees O\n, O\nwho O\nare O\non O\nthe O\nouter O\nlimit O\nof O\nthe O\nstrip O\nthe O\nplanes O\nhave O\nbeen O\nchecking O\n. O\n\n-DOCSTART- O\n\nMauritius B-LOC\nput O\non O\ncyclone O\nalert O\n. O\n\nPORT B-LOC\nLOUIS I-LOC\n1996-12-06 O\n\nMauritian B-MISC\nauthorities O\nput O\nthe O\nIndian B-LOC\nOcean I-LOC\nisland O\non O\ncyclone O\nalert O\non O\nFriday O\n. O\n\nThe O\nweather O\nservices O\noffice O\nsaid O\nthe O\ncentre O\nof O\nthe O\nintense O\ntropical O\ncyclone O\nDaniella B-MISC\nwas O\n570 O\nkm O\n( O\n310 O\nmiles O\n) O\nnorth O\nby O\nnorthwest O\nof O\nthe O\nisland O\non O\nFriday O\nafternoon O\nand O\nwas O\nmoving O\nsouth O\nby O\nsouthwest O\nat O\neight O\nkm O\nan O\nhour O\n( O\nfour O\nknots O\n) O\n. O\n\nAlthough O\nnot O\nthreatening O\nMauritius B-LOC\ndirectly O\n, O\nit O\nis O\ncoming O\ncloser O\nto O\nthe O\nisland O\nand O\ncould O\nchange O\ndirection O\n, O\nit O\nadded O\n. O\n\nWinds O\nup O\nto O\n75 O\nkm O\nan O\nhour O\n( O\n40 O\nknots O\n) O\ncould O\nblow O\nover O\nMauritius B-LOC\nduring O\nthe O\nnight O\nof O\nFriday O\nto O\nSaturday O\n, O\nit O\nsaid O\n. O\n\nThe O\nweather O\nin O\nthe O\ncapital O\nPort B-LOC\nLouis I-LOC\nwas O\nheavily O\ncloudy O\non O\nFriday O\nafternoon O\nwith O\noccasional O\nshowers O\n. O\n\nThe O\nnortheastern O\ncoast O\nof O\nthe O\nnearby O\nisland O\nof O\nMadagascar B-LOC\nhas O\nalso O\ngone O\non O\nalert O\n. O\n\n-DOCSTART- O\n\nU.N. B-ORG\nevacuates O\nstaff O\nfrom O\nCentral B-LOC\nAfrican I-LOC\nRepublic I-LOC\n. O\n\nABIDJAN B-LOC\n1996-12-06 O\n\nThe O\nUnited B-ORG\nNations I-ORG\nevacuated O\nits O\nstaff O\nin O\nthe O\nCentral B-LOC\nAfrican I-LOC\nRepublic I-LOC\non O\nFriday O\nbecause O\nof O\nmounting O\nviolence O\nin O\na O\ntwo-week-old O\narmy O\nmutiny O\nin O\nthe O\ncapital O\n, O\na O\nU.N. B-ORG\nofficial O\nsaid O\n. O\n\nThe O\nofficial O\nfrom O\nthe O\nU.N. B-ORG\nrefugee O\nagency O\nUNHCR B-ORG\nsaid O\na O\nchartered O\nplane O\nhad O\npicked O\nup O\nthe O\nstaff O\nfrom O\nBangui B-LOC\nand O\nwas O\nheading O\nfor O\nAbidjan B-LOC\n, O\nIvory B-LOC\nCoast I-LOC\n. O\n\n-DOCSTART- O\n\nSenegal B-LOC\nproposes O\nforeign O\nminister O\nfor O\nU.N. B-ORG\npost O\n. O\n\nDAKAR B-LOC\n1996-12-06 O\n\nSenegal B-LOC\n's O\nPresident O\nAbdou B-PER\nDiouf I-PER\nsaid O\non O\nFriday O\nhe O\nwas O\nproposing O\nhis O\nforeign O\nminister O\nMoustapha B-PER\nNiasse I-PER\nfor O\nthe O\npost O\nof O\nUnited B-ORG\nNations I-ORG\nsecretary-general O\n. O\n\nDiouf B-PER\nannounced O\nhis O\nintention O\nto O\nreporters O\nwhen O\nhe O\nreturned O\nfrom O\nthe O\nFranco-African B-MISC\nsummit O\nin O\nBurkina B-LOC\nFaso I-LOC\nwhere O\nan O\nAfrican B-MISC\nsuccessor O\nto O\nSecretary-General O\nBoutros B-PER\nBoutros-Ghali I-PER\nwas O\ndiscussed O\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\nhas O\nvetoed O\na O\nsecond O\nterm O\nfor O\nthe O\nEgyptian B-MISC\nbut O\nleft O\nthe O\ndoor O\nopen O\nfor O\nanother O\nAfrican B-MISC\ncandidate O\n. O\n\n\" O\nIf O\nAfrica B-LOC\ndoes O\nnot O\nwish O\nto O\nlose O\nits O\nturn O\nwe O\nhave O\nto O\nact O\nfast O\n, O\n\" O\nDiouf B-PER\nsaid O\n. O\n\" O\n\nSome O\nof O\nmy O\nbrother O\nheads O\nof O\nstate O\nasked O\nme O\nif O\nI O\nwould O\nn't O\nnominate O\nMoustapha B-PER\nNiasse I-PER\n. O\n\nI O\nsee O\nin O\nhim O\nthe O\nprofile O\nof O\na O\nsecretray-general O\nof O\nthe O\nUnited B-ORG\nNations I-ORG\nand O\nI O\nhave O\ngiven O\nmy O\nendorsement O\n. O\n\" O\n\n-DOCSTART- O\n\nEx-minister O\n, O\nson O\nkilled O\nin O\nCentral B-LOC\nAfrica I-LOC\nunrest O\n. O\n\nRaphael B-PER\nKopessoua I-PER\n\nBANGUI B-LOC\n1996-12-06 O\n\nA O\nformer O\ncabinet O\nminister O\nin O\nCentral B-LOC\nAfrican I-LOC\nRepublic I-LOC\nand O\nhis O\nson O\nwere O\nabducted O\nfrom O\ntheir O\nhome O\nand O\nmurdered O\nin O\ngrowing O\nethnic O\nviolence O\nin O\nthe O\ncapital O\nBangui B-LOC\n, O\na O\ngovernment O\nminister O\nsaid O\non O\nFriday O\n. O\n\nWith O\nviolence O\nspiralling O\nout O\nof O\ncontrol O\n, O\nFrance B-LOC\nvoiced O\nbacking O\nfor O\nthe O\nelected O\nBangui B-LOC\ngovernment O\nbut O\nsaid O\nits O\ntroops O\nbased O\nin O\nthe O\nformer O\ncolony O\nunder O\ndefence O\npacts O\nwould O\nnot O\nhelp O\nit O\ncombat O\narmy O\nmutineers O\n. O\n\n\" O\nFrance B-LOC\ncannot O\nbe O\ninvolved O\nin O\nthe O\ndomestic O\npolitical O\ndebate O\n, O\n\" O\nPresident O\nJacques B-PER\nChirac I-PER\ntold O\na O\nnews O\nconference O\nat O\nthe O\nend O\nof O\na O\nFranco-African B-MISC\nsummit O\nin O\nBurkina B-LOC\nFaso I-LOC\n. O\n\n\" O\nFrench B-MISC\ntroops O\nmay O\nonly O\ntake O\npart O\nin O\nmaintaining O\norder O\nto O\navoid O\nmajor O\nabuses O\nand O\nprotect O\nforeign O\ncommunities O\n, O\n\" O\nhe O\nsaid O\n. O\n\nPublic O\nService O\nMinister O\nDavid B-PER\nDofara I-PER\n, O\nwho O\nis O\nthe O\nhead O\nof O\nthe O\nnational O\nRed B-ORG\nCross I-ORG\n, O\ntold O\nReuters B-ORG\nhe O\nhad O\nseen O\nthe O\nbodies O\nof O\nformer O\ninterior O\nminister O\nChristophe B-PER\nGrelombe I-PER\nand O\nhis O\nson O\n, O\nwho O\nwas O\nnot O\nnamed O\n. O\n\nWitnesses O\nsaid O\nthey O\nhad O\nbeen O\nseized O\nby O\ntroops O\nloyal O\nto O\nPresident O\nAnge-Felix B-PER\nPatasse I-PER\nat O\ndawn O\non O\nThursday O\nwhen O\nthey O\nclashed O\nwith O\nsoldiers O\nstaging O\na O\nmutiny O\nsince O\nNovember O\n16 O\n. O\n\nGrelombe B-PER\nis O\nfrom O\nthe O\nYakoma B-MISC\ntribe O\nto O\nwhich O\nmost O\nof O\nthe O\nrebel O\nsoldiers O\nbelong O\n. O\n\nThe O\nuprising O\nbegan O\nover O\npay O\ndemands O\nbut O\nhas O\nturned O\ninto O\na O\ncampaign O\nto O\ntopple O\nPatasse B-PER\n, O\nsparking O\nethnic O\nviolence O\nand O\ndividing O\nthe O\ncapital O\n. O\n\nThe O\nformer O\nminister O\nand O\nhis O\nson O\nhad O\nbeen O\ntaken O\nfrom O\ntheir O\nhome O\nclose O\nto O\nthe O\npresidential O\npalace O\n, O\nwhich O\nis O\nguarded O\nby O\nloyalist O\nsoldiers O\nbacked O\nby O\nFrench B-MISC\ntroops O\nbased O\nin O\nBangui B-LOC\n. O\n\nThe O\nbodies O\nwere O\nfound O\non O\nThursday O\nin O\nan O\nopen O\nfield O\nabout O\ntwo O\nkm O\n( O\none O\nmile O\n) O\nfurther O\naway O\n, O\nsaid O\nDofora B-PER\nand O\nother O\nwitnesses O\n. O\n\nThe O\nmen O\nwere O\nseized O\nas O\nloyalist O\nforces O\nand O\nFrench B-MISC\ntroops O\nfought O\ngunbattles O\nwith O\nmutineers O\nwho O\nfired O\nrockets O\ninto O\nthe O\ncity O\ncentre O\n. O\n\nA O\nFrench-owned B-MISC\nhotel O\nwas O\nslightly O\ndamaged O\n. O\n\nYakomas B-MISC\nare O\nhounded O\nin O\nstronghold O\ndistricts O\nof O\nPatasse B-PER\n's O\nBaya B-MISC\npeople O\nwhile O\nother O\ntribes O\nhave O\nfled O\nareas O\nin O\nrebel O\nhands O\n. O\n\nRoadblocks O\nhave O\nbeen O\nerected O\nin O\ncity O\ndistricts O\nwhile O\ncentral O\nBangui B-LOC\n, O\nwhich O\nis O\npatrolled O\nby O\nFrench B-MISC\ntroops O\nwith O\ntanks O\n, O\nis O\ndeserted O\n. O\n\nShops O\nand O\nbusinesses O\nhave O\nremained O\nshut O\nthis O\nweek O\n. O\n\nThe O\nFranco-African B-MISC\nsummit O\ndecided O\nto O\nsend O\na O\nmission O\nBangui B-LOC\nto O\nseek O\nways O\nof O\ncontaining O\nthe O\nmutiny O\nand O\na O\nthreat O\nof O\ncivil O\nwar O\n. O\n\nChirac B-PER\nsaid O\nBurkina B-LOC\nFaso I-LOC\nPresident O\nBlaise B-PER\nCompaore I-PER\nwould O\nvisit O\nBangui B-LOC\n\" O\nin O\nthe O\ncoming O\nhours O\n\" O\nwith O\nthe O\nheads O\nof O\nstate O\nof O\nGabon B-LOC\n, O\nMali B-LOC\nand O\nChad B-LOC\nto O\ntry O\nand O\nestablish O\ndialogue O\nbetween O\nauthorities O\nand O\nrebels O\n. O\n\nThe O\nmutiny O\nforced O\nPatasse B-PER\nto O\nmiss O\nthe O\nsummit O\n. O\n\nHis O\nspokesman O\nhad O\npredicted O\nthe O\nmeeting O\nto O\nsend O\nan O\nassessment O\nmission O\n. O\n\nPatasse B-PER\n, O\nwho O\nwon O\nCentral B-LOC\nAfrica I-LOC\n's O\nfirst O\nmulti-party O\nelections O\n, O\nrefuses O\nto O\nresign O\n. O\n\nChurch-led O\nmeadiation O\nattempts O\nhit O\ndeadlock O\nover O\nrebel O\ndemands O\nfor O\nhis O\ndeparture O\n. O\n\nSoldiers O\nstaged O\nmutinies O\nin O\nApril O\nand O\nMay O\n, O\nwith O\nFrench B-MISC\ntroops O\nstepping O\nin O\nwith O\ntanks O\nand O\nhelicopters O\nto O\nquell O\nthe O\nmore O\nserious O\nsecond O\nuprising O\n. O\n\nPatasse B-PER\noffered O\nconcessions O\nand O\namnesty O\nto O\nrebels O\nbefore O\nthe O\nMay O\nrebellion O\nended O\nafter O\nrebels O\nlooted O\nthe O\ncity O\ncentre O\n. O\n\nRebels O\naccuse O\nPatasse B-PER\nof O\ntribalism O\nand O\nof O\narming O\nhis O\ncivilian O\nsupporters O\nand O\nhired O\nguns O\nfrom O\nSudan B-LOC\nand O\nChad B-LOC\n. O\n\nMutineers O\nhave O\nvowed O\nto O\ndisarm O\nall O\ncivilians O\nand O\nto O\nchase O\nout O\nthe O\nforeign O\nforces O\nknwon O\nas O\nCodos B-MISC\n. O\n\nHospital O\nsources O\nand O\nwitnesses O\nsaid O\nabout O\n10 O\npeople O\nwere O\nknown O\nto O\nhave O\nbeen O\nkilled O\nin O\nthe O\nmore O\nthan O\ntwo O\nweeks O\nof O\nfighting O\n, O\nincluding O\ntwo O\nrebels O\nkilled O\nin O\nThursday O\n's O\nclashes O\n. O\n\nAn O\nundetermined O\nnumber O\nof O\npeople O\nare O\nreported O\nto O\nhave O\nbeen O\nabducted O\nand O\nkilled O\noutside O\nthe O\ntown O\nby O\ntribal O\nvigilante O\ngroups O\n. O\n\nIn O\nThursday O\n's O\nfighting O\n, O\nFrench B-MISC\ntroops O\nfired O\nback O\nas O\nmutineers O\ntrying O\nto O\nbreak O\nout O\nof O\ntheir O\nstrongholds O\nrained O\nmortar O\nshells O\non O\nthe O\ncity O\ncentre O\n. O\n\n-DOCSTART- O\n\nFive O\ndie O\nas O\nSAfrican B-MISC\ncrop O\nplane O\nhits O\npickup O\n. O\n\nJOHANNESBURG B-LOC\n1996-12-06 O\n\nFive O\npeople O\nwere O\nkilled O\nwhen O\na O\ncrop-spraying O\nplane O\npreparing O\nfor O\ntakeoff O\ncrashed O\ninto O\na O\nlight O\ndelivery O\nvehicle O\nin O\nSouth B-LOC\nAfrica I-LOC\n's O\nNorth B-LOC\nWest I-LOC\nregion O\n, O\nstate O\nradio O\nreported O\non O\nFriday O\n. O\n\nThe O\nfreak O\naccident O\noccurred O\nin O\nMafikeng B-LOC\non O\nThursday O\n. O\n\nThe O\npilot O\nsurvived O\nthe O\ncrash O\n, O\nbut O\nthe O\ndriver O\nand O\npassengers O\nof O\nthe O\nvan O\nwere O\nkilled O\n. O\n\n-DOCSTART- O\n\nWEATHER O\n- O\nConditions O\nat O\nCIS B-LOC\nairports O\n- O\nDec O\n6 O\n. O\n\nMOSCOW B-LOC\n1996-12-06 O\n\nNo O\nweather-related O\nclosures O\nof O\nCIS B-LOC\nairports O\nare O\nexpected O\non O\nDecember O\n7 O\nand O\n8 O\n, O\nthe O\nRussian B-ORG\nWeather I-ORG\nService I-ORG\nsaid O\non O\nFriday O\n. O\n\n-- O\nMoscow B-ORG\nNewsroom I-ORG\n+7095 O\n941 O\n8520 O\n\n-DOCSTART- O\n\nSkinheads O\nattack O\nBratislava B-LOC\nRabbi O\n- O\npolice O\n. O\n\nBRATISLAVA B-LOC\n1996-12-06 O\n\nFour O\nskinheads O\nattacked O\nand O\ninsulted O\nthe O\nrabbi O\nof O\nBratislava B-LOC\n, O\nBaruch B-PER\nMeyers I-PER\n, O\nin O\nthe O\ncity O\ncentre O\non O\nFriday O\n, O\nbut O\nhe O\nescaped O\nunharmed O\n, O\na O\npolice O\nspokesman O\ntold O\nReuters B-ORG\n. O\n\n\" O\nA O\ngroup O\nof O\nfour O\nskinheads O\nattacked O\nthe O\nrabbi O\n, O\none O\nkicked O\nhim O\nin O\nthe O\nhand O\nbut O\ncaused O\nno O\ninjury O\n, O\n\" O\nthe O\nspokesman O\nsaid O\n. O\n\n\" O\nAll O\nfour O\nattackers O\nwere O\napprehended O\nand O\ntwo O\nhave O\nbeen O\ndetained O\n, O\n\" O\nthe O\nspokesman O\nadded O\n\nHe O\nwas O\nunable O\nto O\ngive O\nmore O\ndetails O\n. O\n\n\" O\nThe O\nfurther O\nprocedure O\nis O\nnow O\nin O\nthe O\nhands O\nof O\nthe O\nlocal O\npolice O\ninvestigator O\n, O\n\" O\nthe O\nspokesman O\nsaid O\n. O\n\nIt O\nwas O\nthe O\nsecond O\nattack O\nby O\nskinheads O\nin O\ntwo O\nyears O\non O\nMeyers B-PER\n, O\nan O\nAmerican B-MISC\n. O\n\nMeyers B-PER\nwas O\nnot O\navailable O\nfor O\ncomment O\n. O\n\n-DOCSTART- O\n\nAlbanian B-MISC\njailed O\nfor O\nthreat O\nof O\nbomb O\nsuicide O\n. O\n\nTIRANA B-LOC\n1996-12-06 O\n\nAn O\nAlbanian B-MISC\ncourt O\non O\nFriday O\nsentenced O\na O\nman O\nwho O\nthreatened O\nto O\nblow O\nhimself O\nup O\noutside O\nPresident O\nSali B-PER\nBerisha I-PER\n's O\noffice O\nto O\n13 O\nyears O\nin O\njail O\nfor O\nguerrilla O\naction O\nand O\nillegal O\npossession O\nof O\narms O\n. O\n\nBuza B-PER\nlast O\nApril O\nsaid O\nhe O\nwould O\nblow O\nhimself O\nup O\noutside O\nthe O\npresidential O\npalace O\nunless O\nhe O\nwas O\nallowed O\nto O\nspeak O\nto O\nBerisha B-PER\n, O\nwho O\nwas O\nat O\nthe O\ntime O\nmeeting O\nItalian B-MISC\nPresident O\nOscar B-PER\nLuigi I-PER\nScalfaro I-PER\n. O\n\nBuza B-PER\nwas O\noverpowered O\nby O\nriot O\npolice O\nless O\nthan O\none O\nhour O\nafter O\nhe O\nbegan O\nhis O\naction O\n. O\n\n\" O\nEvaluating O\nall O\nthe O\nconditions O\nof O\nthe O\ncase O\nthe O\ncourt O\nthinks O\nthe O\nsentence O\nshould O\nbe O\nlower O\nthan O\nthe O\nminimum O\n( O\n15 O\nyears O\n) O\n, O\n\" O\nTirana B-LOC\njudge O\nQazim B-PER\nGjonaj I-PER\nadded O\n. O\n\nThe O\ndefendant O\ndenied O\nthe O\ncharges O\n, O\nsaying O\nhis O\naction O\nwas O\nintended O\nto O\nurge O\nthe O\nauthorities O\nto O\ngive O\nhim O\na O\n$ O\n20,000 O\nloan O\n. O\n\nMedical O\nexperts O\nhad O\nconcluded O\nBuza B-PER\nwas O\nmentally O\nunstable O\nbut O\nfully O\nresponsible O\nfor O\nthe O\nact O\nhe O\nhad O\ncommitted O\n, O\nGjonaj B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nPolish B-MISC\nex-communist O\npresident O\nto O\nvisit O\nPope O\n. O\n\nWARSAW B-LOC\n1996-12-06 O\n\nPoland B-LOC\n's O\nex-communist O\nPresident O\nAleksander B-PER\nKwasniewski I-PER\nis O\nlikely O\nto O\nvisit O\nPolish-born O\nPope O\nJohn B-PER\nPaul I-PER\nin O\nearly O\n1997 O\ndespite O\nuneasy O\nrelations O\nbetween O\nthe O\nVatican B-LOC\nand O\nWarsaw B-LOC\n, O\nthe O\nforeign O\nminister O\nsaid O\non O\nFriday O\n. O\n\n\" O\nPresident O\nKwasniewski B-PER\nplans O\nto O\nvisit O\nItaly B-LOC\non O\na O\ninvitation O\nfrom O\nPresident O\nOscar B-PER\nScalfaro I-PER\n. O\n\nA O\nmeeting O\nwith O\nthe O\nPope O\nis O\nalso O\nplanned O\n, O\n\" O\nDariusz B-PER\nRosati I-PER\ntold O\na O\nnews O\nconference O\n. O\n\nRosati B-PER\nsaid O\nthat O\nthe O\natmosphere O\nof O\nthe O\nmeeting O\n, O\nif O\nit O\ntakes O\nplace O\n, O\nwould O\nlargely O\ndepend O\non O\nthe O\nprogress O\nin O\ntalks O\non O\nratification O\nof O\na O\ntreaty O\nbetween O\nWarsaw B-LOC\nand O\nthe O\nVatican B-LOC\n. O\n\n@ O\n\nThe O\nratification O\nof O\nthe O\ntreaty O\n, O\nwhich O\nwas O\nsigned O\nin O\n1993 O\nby O\nthe O\nthen O\nright-centrist O\ngovernment O\n, O\nis O\nbeing O\ndelayed O\nby O\nan O\nex-communist O\nparty O\n, O\nwhich O\nwon O\nparliamentary O\nelections O\nin O\nthe O\nsame O\nyear O\nand O\nnow O\ndominates O\nparliament O\n. O\n\nThe O\nparty O\n, O\nthe O\nDemocratic B-ORG\nLeft I-ORG\nAlliance I-ORG\n, O\nsays O\nthe O\nagreement O\nwould O\ngive O\nthe O\nCatholic B-ORG\nChurch I-ORG\ntoo O\nmuch O\ninfluence O\nover O\nlife O\nin O\nPoland B-LOC\nand O\ncould O\ninfringe O\non O\nrights O\nof O\nother O\nreligious O\ngroups O\nand O\nnon-believers O\n. O\n\nThe O\nrelations O\nwith O\nthe O\nVatican B-LOC\nhave O\nalso O\nbeen O\nsoured O\nby O\na O\nrecent O\nrelaxation O\nof O\nPoland B-LOC\n's O\nanti-abortion O\nrules O\n, O\nwhich O\nKwasniewski B-PER\nsigned O\ninto O\nlaw O\nlast O\nmonth O\n. O\n\n-DOCSTART- O\n\nRussia B-LOC\nwarns O\nNorilsk B-ORG\n, O\nnot O\nexpected O\nto O\nliquidate O\nit O\n. O\n\nLynnley B-PER\nBrowning I-PER\n\nMOSCOW B-LOC\n1996-12-06 O\n\nRussian B-MISC\nFinance O\nMinister O\nAlexander B-PER\nLivshits I-PER\nwarned O\nfinancially-troubled O\nNorilsk B-ORG\nNickel I-ORG\non O\nFriday O\nthat O\nit O\nmust O\npay O\noverdue O\ntaxes O\n, O\nbut O\nanalysts O\nsaid O\nthe O\nfirm O\nwould O\nnot O\nbe O\nliquidated O\nor O\nthat O\nits O\nwould O\nassets O\nwould O\nbe O\nfrozen O\n. O\n\n\" O\nNorilsk B-ORG\nreally O\nis O\na O\nbig O\ndebtor O\n, O\nboth O\nto O\nthe O\nfederal O\nand O\nregional O\nbudgets O\n, O\n\" O\nsaid O\nKonstantin B-PER\nChernyshev I-PER\n, O\nequities O\nanalyst O\nat O\nMoscow B-LOC\nbrokerage O\nRinaco B-ORG\nPlus I-ORG\nand O\na O\nNorilsk B-ORG\nwatcher O\n. O\n\" O\n\nLivshits B-PER\n's O\nwords O\nare O\nan O\nattempt O\nto O\nput O\npressure O\non O\nthe O\ncompany O\n. O\n\" O\n\nThe O\nofficial O\nItar-Tass B-ORG\nnews O\nagency O\nquoted O\nLivshits B-PER\nas O\ntelling O\nparliamentary O\ndeputies O\nthat O\nRAO B-ORG\nNorilsky I-ORG\nNikel I-ORG\n0#NKEL.RUO O\nhad O\nto O\npay O\nits O\ntax O\narrears O\nand O\nthat O\nbankruptcy O\nprocedures O\napplied O\nto O\nthe O\nmetals O\ngroup O\n. O\n\n\" O\nIf O\nit O\nwas O\nan O\nunsolicited O\nstatement O\nand O\na O\nbolt O\nout O\nof O\nthe O\nblue O\n, O\nthen O\nit O\nobviously O\nmeans O\nsomething O\n, O\n\" O\nsaid O\nChristopher B-PER\nGranville I-PER\n, O\nchief O\neconomist O\nat O\nUnited B-ORG\nCity I-ORG\nBank I-ORG\nin O\nMoscow B-LOC\n. O\n\n\" O\nBut O\nif O\nit O\nwas O\na O\nresponse O\nto O\na O\ndeputy O\n's O\nquestion O\nthat O\nwas O\nessentially O\nloaded O\n, O\nthen O\nit O\nwas O\nthe O\nonly O\nanswer O\nhe O\ncould O\nhave O\ngiven O\n. O\n\" O\n\nRussian B-MISC\ntax O\nand O\ncabinet O\nauthorities O\n, O\nunder O\npressure O\nfrom O\nthe O\nInternational B-ORG\nMonetary I-ORG\nFund I-ORG\nto O\nboost O\ntax O\nrevenues O\nas O\na O\ncondition O\nfor O\nreceiving O\npayments O\nof O\na O\n$ O\n10 O\nbillion O\n, O\nthree-year O\nloan O\nto O\nMoscow B-LOC\n, O\nhave O\nbeen O\nstriking O\nfear O\ninto O\nthe O\nhearts O\nof O\nsome O\nof O\nRussia B-LOC\n's O\nmost O\nprominent O\nindustrial O\nfirms O\nby O\nsaying O\nthey O\nmust O\npay O\nup O\nor O\nface O\nliquidation O\n. O\n\n\" O\nThey O\ncould O\nfreeze O\nmetal O\n, O\nbut O\nit O\n's O\nnot O\na O\nlong-term O\nsolution O\nto O\nthe O\nproblem O\nand O\nwould O\nn't O\nput O\nmoney O\nin O\nthe O\nbudget O\n, O\n\" O\nChernyshev B-PER\nsaid O\n. O\n\" O\n\nI O\ndo O\nn't O\nthink O\nthey O\nwould O\ndo O\nthat O\n. O\n\" O\n\nEntire O\nsocial O\ninfrastructures O\nin O\nthe O\nicy O\nFar O\nNorth O\nwhere O\nNorilsk B-ORG\nis O\nbased O\ndepend O\non O\nthe O\ncompany O\n, O\nand O\nMoscow B-LOC\nhas O\nsaid O\nit O\nhas O\nno O\nfinances O\nto O\nresettle O\nhundreds O\nof O\nthousands O\nof O\npeople O\n-- O\nan O\nexpenditure O\nwhich O\ncould O\nfar O\noutstrip O\nNorilsk B-ORG\n's O\ndebts O\n. O\n\nNorilsk B-ORG\nofficials O\ndeclined O\nto O\ncomment O\n. O\n\nAnalysts O\nsaid O\nthe O\ngovernment O\n, O\nwhile O\nanxious O\nabout O\nNorilsk B-ORG\n's O\ndebts O\n, O\nis O\nhighly O\nunlikely O\nto O\nbring O\nthe O\nnickel O\n, O\ncopper O\n, O\ncobalt O\n, O\nplatinum O\nand O\nplatinum O\ngroup O\nmetals O\nproducer O\nto O\nits O\nknees O\nor O\ntake O\nmeasures O\nthat O\ncould O\nsignificantly O\naffect O\noutput O\n. O\n\nBut O\nit O\nalso O\nwants O\nNorilsk B-ORG\n, O\nthe O\nworld O\n's O\nsecond-largest O\nnickel O\nproducer O\n, O\nto O\nclean O\nup O\nits O\nact O\n. O\n\n\" O\nThe O\nprocedure O\nof O\nbankruptcy O\nwill O\nbe O\napplied O\n, O\n\" O\nTass B-ORG\nquoted O\nLivshits B-PER\nas O\ntelling O\nDuma B-ORG\ndeputies O\nabout O\nNorilsk B-ORG\n. O\n\nIt O\nindirectly O\nquoted O\nhim O\nas O\nsaying O\nNorilsk B-ORG\nshould O\nfirst O\npay O\nsalary O\narrears O\n, O\nwhich O\nin O\nthe O\npast O\nhave O\nled O\nto O\nworker O\nstrikes O\n. O\n\n\" O\nIt O\nis O\nunlikely O\nthat O\nNorilsk B-ORG\nwill O\npay O\nthese O\ndebts O\nin O\nthe O\nnear-term O\n-- O\nthe O\ncompany O\nwill O\nremain O\na O\ndebtor O\nin O\nthe O\nnear O\nfuture O\n, O\n\" O\nChernyshev B-PER\nsaid O\n. O\n\nHe O\nestimated O\nthe O\ncompany O\n's O\nregional O\ndebts O\nat O\nleast O\none O\ntrillion O\nroubles O\nand O\nsaid O\n30 O\npercent O\nof O\nthe O\ngiant O\nKrasnoyarsk B-LOC\nregional O\nbudget O\nwas O\nfuelled O\nby O\nNorilsk B-ORG\nmoney O\n. O\n\nNorilsk B-ORG\n's O\nnew O\nmajority O\nshareholder O\n, O\nRussian B-MISC\ncommerical O\nbank O\nUneximbank B-ORG\n, O\nhas O\nsaid O\nit O\nis O\nreorganising O\nmetal O\nexports O\nthrough O\nInterrosimpex B-ORG\nin O\norder O\nto O\nboost O\nrevenues O\n. O\n\nBut O\nthe O\nchanges O\nhave O\nyet O\nto O\nimprove O\nsignificantly O\nNorilsk B-ORG\n's O\nsituation O\n. O\n\n\" O\nUneximbank B-ORG\nhas O\ninherited O\na O\nmountain O\nand O\nwhether O\nor O\nnot O\nthey O\nclimb O\nout O\nand O\nover O\nit O\nremains O\nto O\nbe O\nseen O\n, O\n\" O\nsaid O\none O\nmetals O\nsource O\n. O\n\nNorilsk B-ORG\nsaid O\nin O\nSeptember O\nthat O\nit O\ntotal O\ndebts O\n, O\nincluding O\nunpaid O\nsalaries O\nto O\nworkers O\n, O\nwere O\n13 O\ntrillion O\nroubles O\n. O\n\nThe O\ncompany O\nsaid O\nlast O\nmonth O\nthat O\nit O\nhad O\nworked O\nout O\na O\ntax O\npayment O\nschedule O\nwith O\nauthorities O\n, O\nafter O\nregional O\ntax O\nofficials O\nthreatened O\nto O\nseize O\nsome O\nnickel O\nand O\ncopper O\nassets O\n. O\n\n-- O\nMoscow B-ORG\nNewsroom I-ORG\n, O\n+7095 O\n941 O\n8520 O\n\n-DOCSTART- O\n\nEstonian B-MISC\nTallinna B-ORG\nPank I-ORG\n11-mo O\nnet O\n46.6 O\nmln O\nkroons O\n. O\n\nTALLINN B-LOC\n1996-12-06 O\n\nTallinna B-ORG\nPank I-ORG\n, O\none O\nof O\nthe O\nlargest O\nbanks O\nin O\nEstonia B-LOC\n, O\nmade O\na O\n11-month O\n1996 O\nnet O\nprofit O\nof O\n46.6 O\nmillion O\nkroons O\n, O\nthe O\nbank O\nsaid O\non O\nFriday O\n. O\n\nIt O\nsaid O\nin O\na O\nstatement O\nthat O\nit O\nmade O\nprofits O\nof O\n4.5 O\nmillion O\nkroons O\nin O\nNovember O\n. O\n\nThe O\nbank O\nmade O\na O\nprofit O\nof O\n20.1 O\nmillion O\nkroons O\nin O\nthe O\nfirst O\nhalf O\nof O\nthe O\nyear O\n. O\n\nTallinna B-ORG\nPank I-ORG\nsaid O\nits O\nassets O\nrose O\n17.8 O\nmillion O\nkroons O\nto O\n1.84 O\nbillion O\nkroons O\n. O\n\nDemand O\ndeposits O\nrose O\nto O\n855.8 O\nmillion O\nkroons O\nfrom O\n834.6 O\nmillion O\nkroons O\nand O\ntime O\ndeposits O\nincreased O\nto O\n295.1 O\nmillion O\nkroons O\nfrom O\n285.3 O\nmillion O\nkroons O\n. O\n\n-- O\nRiga B-ORG\nNewsroom I-ORG\n, O\n+371 O\n721 O\n5240 O\n\n-DOCSTART- O\n\nRussia B-LOC\nready O\nfor O\nconstructive O\nwork O\nwith O\nAlbright B-PER\n. O\n\nMOSCOW B-LOC\n1996-12-06 O\n\nRussia B-LOC\nsaid O\non O\nFriday O\nit O\nexpected O\na O\nconstructive O\nrelationship O\nwith O\nMadeleine B-PER\nAlbright I-PER\n, O\nnominated O\nby O\nU.S. B-LOC\nPresident O\nBill B-PER\nClinton I-PER\nto O\nbe O\nSecretary O\nof O\nState O\n. O\n\nInterfax B-ORG\nnews O\nagency O\nquoted O\nFirst O\nDeputy O\nForeign O\nMinister O\nIgor B-PER\nIvanov I-PER\nas O\nsaying O\nMoscow B-LOC\nwas O\nready O\nfor O\n\" O\nmost O\nactive O\nand O\nconstructive O\n\" O\nwork O\nwith O\nAlbright B-PER\n. O\n\nBut O\nhe O\nnoted O\nthat O\npolicy O\nwould O\nbe O\nshaped O\nby O\nClinton B-PER\nand O\nPresident O\nBoris B-PER\nYeltsin I-PER\n. O\n\nClinton B-PER\nand O\nYeltsin B-PER\nare O\ndue O\nto O\nmeet O\nnext O\nMarch O\nfor O\ntheir O\nfirst O\nsummit O\nsince O\nboth O\nwere O\nre-elected O\n. O\n\n\" O\nOur O\ncountries O\n' O\nleaders O\nhave O\nagreed O\nto O\nmeet O\nin O\nMarch O\n, O\n1997 O\n. O\n\nThe O\nRussian B-MISC\nforeign O\nministry O\nbelieves O\nthe O\nnew O\ndirections O\nin O\nthe O\ndevelopment O\nof O\nRussian-U.S. B-MISC\nrelations O\nwill O\nbe O\nworked O\nout O\nthere O\n, O\n\" O\nIvanov B-PER\ntold O\nInterfax B-ORG\n. O\n\nInterfax B-ORG\n, O\noutlining O\nAlbright B-PER\n's O\nbiography O\n, O\npointed O\nout O\nthat O\nshe O\nhad O\ndefended O\nWashington B-LOC\n's O\ninterests O\nfiercely O\nas O\nU.S. B-LOC\nambassador O\nto O\nthe O\nUnited B-ORG\nNations I-ORG\nand O\nthat O\nthis O\nhad O\nincluded O\nactively O\nsupporting O\nNATO B-ORG\n's O\nplans O\nto O\nexpand O\neastwards O\n. O\n\nRussia B-LOC\nopposes O\nNATO B-ORG\n's O\nplans O\nto O\ntake O\nin O\ncountries O\nof O\neastern O\nand O\ncentral O\nEurope B-LOC\nwhich O\nused O\nto O\nbe O\npart O\nof O\nthe O\nSoviet-led B-MISC\nWarsaw B-MISC\nPact I-MISC\n, O\nsaying O\nsuch O\nmoves O\nwould O\nthreaten O\nits O\nsecurity O\n. O\n\n-DOCSTART- O\n\nYeltsin B-PER\nplans O\nreturn O\nto O\nKremlin B-LOC\nfor O\nDec O\n25 O\n- O\nspeaker O\n. O\n\nMOSCOW B-LOC\n1996-12-06 O\n\nRussian B-MISC\nPresident O\nBoris B-PER\nYeltsin I-PER\n, O\nwho O\nhad O\nheart O\nbypass O\nsurgery O\na O\nmonth O\nago O\n, O\nplans O\nto O\nreturn O\nto O\nwork O\non O\nDecember O\n25 O\n, O\nthe O\nhead O\nof O\nthe O\nupper O\nchamber O\nof O\nparliament O\ntold O\nInterfax B-ORG\nnews O\nagency O\non O\nFriday O\n. O\n\n\" O\nToday O\nhe O\nis O\na O\nmobile O\n, O\nenergetic O\nman O\nwith O\nlots O\nof O\ncolour O\nin O\nhis O\ncheeks O\n, O\n\" O\nsaid O\nYegor B-PER\nStroyev I-PER\nwho O\nmet O\nYeltsin B-PER\n, O\n65 O\n, O\non O\nFriday O\nat O\na O\ncountry O\nresidence O\n. O\n\" O\n\nHe O\ntold O\nme O\nthat O\nhe O\nhad O\nlost O\n20 O\nkg O\n( O\n44 O\nlbs O\n) O\nwhich O\nis O\nnatural O\nafter O\nsuch O\nan O\noperation O\n. O\n\" O\n\nDecember O\n25 O\n, O\na O\nnormal O\nworking O\nday O\nin O\nRussia B-LOC\n, O\nis O\nthe O\nfifth O\nanniversary O\nof O\nYeltsin B-PER\n's O\narrival O\nin O\nthe O\nKremlin B-LOC\n. O\n\nHe O\ntook O\nover O\nthere O\n, O\nand O\ntook O\ncontrol O\nof O\nthe O\nred O\nbutton O\ncontrolling O\nnuclear O\narms O\n, O\nin O\nDecember O\n1991 O\nwhen O\nMikhail B-PER\nGorbachev I-PER\nresigned O\n, O\nmarking O\nthe O\nend O\nof O\nthe O\nSoviet B-LOC\nUnion I-LOC\n. O\n\nYeltsin B-PER\nhas O\nbeen O\nshown O\na O\nfew O\ntimes O\non O\ntelevision O\nsince O\nhis O\nquintuple O\nbypass O\non O\nNovember O\n5 O\nbut O\nhas O\nyet O\nto O\ndeliver O\nany O\nmajor O\ntelevision O\nor O\nradio O\naddress O\nto O\nthe O\nnation O\n. O\n\nSurgeon O\nRenat B-PER\nAkchurin I-PER\nwho O\nled O\nthe O\noperation O\n, O\ntold O\nItar-Tass B-ORG\nnews O\nagency O\nYeltsin B-PER\nwas O\nworking O\nup O\nto O\nfour O\nhours O\na O\nday O\nat O\nhis O\nresidence O\n. O\n\n-DOCSTART- O\n\nBomb O\nexplodes O\noutside O\nhome O\nof O\nexpelled O\nSlovak B-MISC\nMP O\n. O\n\nBRATISLAVA B-LOC\n1996-12-06 O\n\nA O\nbomb O\nexploded O\non O\nFriday O\noutside O\nthe O\nhome O\nof O\na O\nSlovak B-MISC\npolitician O\nexpelled O\nfrom O\nparliament O\nafter O\nhe O\nquit O\nthe O\nruling O\nparty O\n, O\ncomplaining O\nof O\na O\nlack O\nof O\ndemocracy O\nin O\nthe O\ncountry O\n. O\n\nThe O\nofficial O\nTASR B-ORG\nnews O\nagency O\nsaid O\nthe O\nexplosion O\nblew O\nout O\nall O\nground O\nfloor O\nwindows O\nof O\nFrantisek B-PER\nGaulieder I-PER\n's O\nfamily O\nhome O\nin O\nGalanta B-LOC\n, O\nwestern O\nSlovakia B-LOC\n, O\nand O\ndamaged O\nthe O\nmain O\nentrance O\n, O\nbut O\nno-one O\nwas O\ninjured O\n. O\n\nGaulieder B-PER\n, O\nformerly O\na O\nmember O\nof O\nPrime O\nMinister O\nVladimir B-PER\nMeciar I-PER\n's O\nruling O\nMovement B-ORG\nfor I-ORG\na I-ORG\nDemocratic I-ORG\nSlovakia I-ORG\n, O\nwas O\nstripped O\nof O\nhis O\nparliamentary O\nmandate O\non O\nWednesday O\nafter O\nleaving O\nthe O\nparty O\nlast O\nmonth O\nin O\nprotest O\nover O\nwhat O\nhe O\nsaid O\nwas O\na O\nlack O\nof O\ndemocracy O\nin O\nthe O\ncountry O\n. O\n\nHe O\nsaid O\nhe O\nhad O\nbeen O\nreceiving O\nanonymous O\ndeath O\nthreats O\nsince O\nmaking O\nthe O\nmove O\n. O\n\n\" O\nThis O\nwas O\nan O\nact O\nof O\nterrorism O\nand O\nnow O\nI O\nfear O\nnot O\nonly O\nfor O\nmy O\nown O\nlife O\n, O\nbut O\nalso O\nof O\nthat O\nof O\nmy O\nwife O\nand O\nchildren O\n, O\n\" O\nhe O\ntold O\nTASR B-ORG\n. O\n\nGaulieder B-PER\n's O\nfamily O\nwas O\nsleeping O\nin O\na O\nbedroom O\nat O\nthe O\nback O\nof O\nthe O\nhouse O\nand O\nwere O\nunharmed O\nby O\nthe O\nblast O\n. O\n\nIt O\nwas O\nnot O\nimmediately O\nclear O\nwho O\nwas O\nbehind O\nthe O\nblast O\n. O\n\n-DOCSTART- O\n\nBomb O\nexplodes O\nat O\nmosque O\nin O\ncentral O\nBulgaria B-LOC\n. O\n\nSOFIA B-LOC\n1996-12-06 O\n\nA O\nbomb O\nexploded O\non O\nFriday O\nat O\na O\nmosque O\nin O\nthe O\ncentral O\nBulgarian B-MISC\ntown O\nof O\nKazanluk B-LOC\n, O\ncausing O\ndamage O\nbut O\nno O\ninjuries O\n, O\nstate O\nradio O\nsaid O\n. O\n\nViolent O\ncrime O\nhas O\nsoared O\nsince O\nthe O\ncollapse O\nof O\ncommunism O\nin O\n1989 O\nas O\nBulgaria B-LOC\nmoves O\nto O\na O\nmarket O\neconomy O\n. O\n\nBombings O\nare O\noften O\ncarried O\nout O\nby O\ncriminals O\nto O\nsettle O\nscores O\nbut O\nthe O\nmotive O\nin O\nthis O\ncase O\nwas O\nnot O\nimmediately O\nclear O\n. O\n\nSome O\nresidents O\nof O\nthe O\nKazanluk B-LOC\narea O\nare O\nMoslems B-MISC\nwho O\nconverted O\nto O\nIslam B-MISC\nduring O\nOttoman O\nTurkish B-MISC\nrule O\n. O\n\nThe O\nmajority O\nin O\nBulgaria B-LOC\nare O\nChristians B-MISC\n. O\n\nThe O\nradio O\nquoted O\npolice O\nas O\nsaying O\nthe O\nblast O\nbroke O\nwindows O\nand O\nshattered O\nthe O\ndoor O\nof O\nthe O\nmosque O\n. O\n\n-DOCSTART- O\n\nHungary B-LOC\no O\n/ O\nn O\nrates O\nend O\nup O\nbefore O\nDec O\n10 O\ntax O\npayment O\n. O\n\nBUDAPEST B-LOC\n1996-12-06 O\n\nHungarian B-MISC\novernight O\ninterest O\nrates O\nclosed O\nhigher O\non O\nFriday O\nas O\nmarket O\nliquidity O\ntightened O\nbefore O\nthe O\nDecember O\n10 O\nsocial O\nsecurity O\ncontribution O\npayment O\ndeadline O\n, O\ndealers O\nsaid O\n. O\n\n\" O\nThe O\nbanks O\nare O\nalready O\npreparing O\nfor O\nthe O\nDecember O\n10 O\ntax O\npayment O\n, O\n\" O\nsaid O\nBudapest B-LOC\nBank O\n's O\nSandor B-PER\nTolonics I-PER\n. O\n\" O\n\nThey O\nexpect O\na O\nlarger-than-average O\npayment O\n. O\n\" O\n\nThe O\novernight O\nmarket O\nopened O\nat O\n22.00 O\n/ O\n22.75 O\npercent O\n, O\nthen O\nsubstantial O\nmoney O\nwas O\ntaken O\nup O\nat O\n22.5 O\npercent O\n. O\n\nBut O\nlater O\n, O\nrates O\ndropped O\nand O\nclosed O\nat O\n22.00 O\n/ O\n22.25 O\nas O\na O\nlarge O\nbank O\nfinished O\nborrowing O\nmoney O\n. O\n\nOn O\nThursday O\n, O\novernight O\nrates O\nmoved O\nbetween O\n21.625 O\nand O\n22.125 O\n. O\n\nDealers O\nsaid O\nliquidity O\ncould O\ntighten O\nfurther O\nearly O\nnext O\nweek O\nas O\nthe O\nsocial O\nsecurity O\ncontribution O\npayments O\ndate O\napproaches O\n. O\n\n-- O\nSandor B-PER\nPeto I-PER\n, O\nBudapest B-LOC\nnewsroom O\n( O\n36 O\n1 O\n) O\n327 O\n4040 O\n\n-DOCSTART- O\n\nMexico B-LOC\nstocks O\noff O\nlows O\nbut O\nstill O\nhit O\nby O\nGreenspan B-PER\n. O\n\nMEXICO B-LOC\nCITY I-LOC\n\nMexican B-MISC\nstocks O\nclosed O\nsharply O\nlower O\nFriday O\n, O\nbut O\nhad O\nmade O\na O\ntentative O\nrecovery O\nas O\ninitial O\npanic O\nand O\nvolatility O\nabated O\n. O\n\n\" O\nIt O\nwas O\nGreenspan B-PER\nat O\nfirst O\n. O\n\nThen O\nonce O\nwe O\nsaw O\nthe O\nDow B-MISC\n( O\nJones B-MISC\nindustrial O\naverage O\n) O\nwas O\nnot O\nabout O\nto O\ncrash O\n, O\nsome O\nbuyers O\nstepped O\nin O\n, O\n\" O\nsaid O\na O\ntrader O\n, O\nreferring O\nto O\nFederal B-ORG\nReserve I-ORG\nChairman O\nAlan B-PER\nGreenspan I-PER\n, O\nwhose O\ncomments O\nthat O\nassets O\nwere O\n\" O\nirrationally O\nexhuberant O\n\" O\nupset O\nfinancial O\nmarkets O\nworldwide O\n. O\n\nThe O\nblue-chip O\nIPC B-MISC\nindex O\nended O\ndown O\n1.29 O\npoints O\n, O\nor O\n43.56 O\npercent O\n, O\nat O\n3,333.05 O\n. O\n\nVolume O\nwas O\nregular O\nat O\n74.7 O\nmillion O\nshares O\ntraded O\n. O\n\nMexican B-MISC\nstocks O\nwere O\nalso O\nhurt O\nby O\nU.S. B-LOC\nlong O\nbond O\nrates O\nwhich O\nhad O\nbegun O\nto O\nrise O\nbefore O\nGreenspan B-PER\n's O\ncomments O\nand O\nwere O\ninflated O\nby O\nemployment O\ndata O\nreleased O\nbefore O\ntrade O\nbegan O\nin O\nMexico B-LOC\n. O\n\nYields O\non O\nU.S. B-LOC\n30-year O\nTreasury B-ORG\nbonds O\nwere O\n6.51 O\npercent O\nwhen O\nstock O\ntrading O\nclosed O\nin O\nMexico B-LOC\n, O\nunchanged O\nfrom O\nThursday O\n. O\n\nOn O\nthe O\nbroad O\nmarket O\n, O\n107 O\nstocks O\nchanged O\nhands O\n, O\nof O\nwhich O\nlosers O\nwell O\noutnumbered O\nwinners O\nby O\n75 O\nto O\n13 O\n. O\n\nTraders O\nnoted O\nthe O\nlack O\nof O\nblue O\nchips O\nor O\nstocks O\ntraded O\nat O\nsignificant O\nvolume O\namong O\nthe O\ngainers O\n. O\n\nSimec B-ORG\n, O\nthe O\nsteelmaking O\narm O\nof O\nthe O\ndebt-ridden O\nSidek B-ORG\ngroup O\nheaded O\nthe O\nlosers O\n, O\noff O\n7 O\ncentavos O\n( O\n1 O\ncent O\n) O\nat O\n1.40 O\npesos O\n( O\n18 O\ncents O\n) O\n. O\n\nSidek B-ORG\nfell O\n4 O\ncentavos O\n( O\n1 O\ncent O\n) O\nto O\n95 O\ncentavos O\n( O\n12 O\ncents O\n) O\n. O\n\nTraders O\nalso O\nremarked O\nthat O\nMexican B-MISC\nADRs B-MISC\nsuffered O\nin O\nNew B-LOC\nYork I-LOC\n. O\n\nHeavyweights O\nTelmex B-ORG\nand O\nTelevisa B-ORG\nended O\noff O\n25 O\ncents O\nand O\n75 O\ncents O\n, O\nrespectively O\n, O\nat O\n$ O\n31.125 O\nand O\n$ O\n25.875 O\n. O\n\n\" O\nFalling O\nshare O\nprices O\nin O\nNew B-LOC\nYork I-LOC\ndo O\nn't O\nhurt O\nMexico B-LOC\nas O\nlong O\nas O\nit O\nhappens O\ngradually O\n, O\nas O\nearlier O\nthis O\nweek O\n. O\n\nIt O\n's O\na O\nsudden O\nplunge O\nthat O\ntakes O\nits O\ntoll O\n, O\n\" O\nsaid O\nCarlos B-PER\nPonce I-PER\n, O\nresearch O\ndirector O\nat O\nSantander B-LOC\n. O\n\nTraders O\nand O\nanalysts O\ndiffered O\nas O\nto O\nhow O\nfirm O\nthe O\nrelative O\nrecovery O\non O\nFriday O\nwas O\n. O\n\n\" O\nSome O\nbuyers O\nstepped O\nin O\n, O\nbut O\nthe O\nmarket O\nwas O\nnot O\nvery O\nconvinced O\n. O\n\nVolume O\nwas O\nlackluster O\n, O\n\" O\nsaid O\none O\ntrader O\n. O\n\n\" O\nThe O\nmarket O\n's O\nvery O\nhealthy O\n, O\nwe O\n're O\nbuying O\n, O\n\" O\nsaid O\nanother O\ntrader O\n. O\n\nPonce B-PER\nsaid O\nshares O\nwere O\ncertainly O\nattractively O\npriced O\nin O\nMexico B-LOC\n, O\nbut O\nwould O\nnot O\nappreciate O\nuntil O\nforeign O\nbuyers O\nstepped O\nin O\n, O\nwhich O\nthey O\nhad O\nyet O\nto O\ndo O\n. O\n' O\n\n-DOCSTART- O\n\nPlastic O\nsurgery O\ngets O\nboost O\nin O\nBrazil B-LOC\n. O\n\nSimona B-PER\nde I-PER\nLogu I-PER\n\nRIO B-LOC\nDE I-LOC\nJANEIRO I-LOC\n1996-12-06 O\n\nPlastic O\nsurgery O\nis O\nbooming O\n, O\nespecially O\namong O\nmen O\n, O\nas O\nBrazilians B-MISC\nspend O\nmuch O\nof O\ntheir O\nnew-found O\nwealth O\non O\nthe O\nlatest O\nbeauty O\ntreatments O\n, O\nsaid O\nthe O\norganisers O\nof O\na O\nfour-day O\ninternational O\nplastic O\nsurgery O\nconference O\nthat O\nopened O\non O\nFriday O\n. O\n\nThe O\nnumber O\nof O\nplastic O\nsurgeries O\nin O\nBrazil B-LOC\nhas O\njumped O\n30 O\npercent O\nto O\nan O\nestimated O\n150,000 O\nthis O\nyear O\nsince O\nan O\nanti-inflation O\nplan O\nwas O\nintroduced O\nin O\nJuly O\n1994 O\n, O\nFarid B-PER\nHakme I-PER\n, O\nthe O\npresident O\nof O\nthe O\nBrazilian B-ORG\nPlastic I-ORG\nSurgery I-ORG\nSociety I-ORG\n( O\nSBCP B-ORG\n) O\n, O\nsaid O\n. O\n\nThe O\nnumber O\nof O\noperations O\non O\nmen O\nincreased O\neven O\nmore O\n-- O\nby O\n80 O\npercent O\n, O\nfrom O\n8,000 O\nin O\n1994 O\nto O\n15,000 O\nin O\n1995 O\n, O\nhe O\nsaid O\n. O\n\n\" O\nBrazil B-LOC\nranks O\nright O\nat O\nthe O\ntop O\nfor O\nplastic O\nsurgery O\nwith O\nrespect O\nto O\nthe O\nnumber O\nof O\nsurgeons O\n, O\nthe O\nnumber O\nof O\npatients O\n, O\nnumber O\nof O\noperations O\n, O\nnumber O\nof O\nconferences O\n. O\n\nOur O\nstatistics O\nare O\nthe O\nhighest O\nfor O\neverything O\n, O\n\" O\nHakme B-PER\nsaid O\n. O\n\n\" O\nWe O\nbelieve O\nthe O\nincrease O\nin O\nplastic O\nsurgeries O\nfor O\nmen O\nresults O\nfrom O\nthe O\ndifficulties O\nin O\nthe O\njob O\nmarket O\n. O\n\nPeople O\nneed O\nto O\nhave O\na O\nmore O\nyouthful O\nlook O\nto O\ncompete O\nin O\nthe O\njob O\nmarket O\n, O\ngiven O\nthe O\nprofound O\nchanges O\nin O\nLatin B-LOC\nAmerica I-LOC\n's O\neconomy O\n. O\n\" O\n\nA O\ncontrolled O\nexchange O\nrate O\n, O\ntrade O\nliberalisation O\nand O\ntight O\nmonetary O\npolicies O\nhave O\nalso O\ndramatically O\ncurbed O\ninflation O\n, O\nmaking O\nmore O\nmoney O\navailable O\nfor O\ncosmetic O\nsurgery O\n. O\n\nBrazil B-LOC\nhas O\nbeen O\nat O\nthe O\nforefront O\nin O\nplastic O\nsurgery O\nfor O\ndecades O\nand O\nis O\nhome O\nto O\none O\nof O\nthe O\nmost O\nfamous O\nsurgeons O\n, O\nIvo B-PER\nPitangy I-PER\n. O\n\nThere O\nare O\n6,000 O\nplastic O\nsurgeons O\nthere O\n, O\nof O\nwhich O\n4,500 O\nhave O\nqualified O\nto O\nbe O\nmembers O\nof O\nthe O\nSBCP B-ORG\n. O\n\nEvery O\nyear O\n, O\n500 O\nnew O\nplastic O\nsurgeons O\ngraduate O\nin O\nBrazil B-LOC\nand O\nmedical O\nstudents O\nfrom O\nall O\nover O\nthe O\nworld O\ncome O\nto O\nstudy O\nthere O\n. O\n\nHakme B-PER\nattributes O\nBrazil B-LOC\n's O\nfascination O\nwith O\nplastic O\nsurgery O\nnot O\nto O\nexcessive O\nvanity O\nbut O\nto O\nthe O\ncountry O\n's O\nmix O\nand O\nmatch O\nof O\ndifferent O\nraces O\n, O\nwhich O\ncan O\ncreate O\nphysical O\ndisharmonies O\n. O\n\" O\n\nWhat O\nhappens O\nis O\nthe O\nnose O\nsometimes O\ndoes O\nn't O\nmatch O\nthe O\nmouth O\nor O\nthe O\nbuttocks O\ndo O\nn't O\nmatch O\nwith O\nthe O\nlegs O\n, O\n\" O\nhe O\nsaid O\n. O\n\nBrazil B-LOC\n's O\nmost O\nsought-after O\nbeauty O\ntreatment O\nis O\nliposuction O\nin O\nwhich O\nfat O\nis O\nsucked O\naway O\nfrom O\nareas O\nof O\nthe O\nbody O\n, O\nwith O\nabout O\n30,000 O\noperations O\na O\nyear O\nat O\na O\ncost O\nof O\n$ O\n3,000 O\nto O\n$ O\n4,000 O\neach O\n. O\n\nStomach O\ntucks O\nand O\nbreast O\noperations O\nare O\nalso O\npopular O\nsince O\nthe O\ntropical O\nclimate O\ncalls O\nfor O\nflesh-baring O\nfashions O\n, O\nbut O\nunlike O\nwomen O\nelsewhere O\nBrazilians B-MISC\ntend O\nto O\nhave O\nbreast O\nreductions O\nand O\nbuttock O\nimplants O\n. O\n\n\" O\nThe O\nwomen O\nwho O\nwant O\nto O\nreduce O\ntheir O\nbreasts O\nhere O\nwould O\nprobably O\nwant O\nto O\nincrease O\nthem O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\n, O\n\" O\nSBCP B-ORG\nVice-President O\nOswaldo B-PER\nSaldanha I-PER\nsaid O\n. O\n\" O\n\nBeauty O\nideals O\nand O\ncultures O\nare O\ndifferent O\nin O\nevery O\ncountry O\n. O\n\" O\n\nPlastic O\nsurgery O\nscares O\nlike O\nthe O\ncase O\nin O\nwhich O\nBrazilian B-MISC\nmodel O\nClaudia B-PER\nLiz I-PER\nfell O\ninto O\na O\ncoma O\nafter O\nbeing O\nanaesthetised O\nfor O\na O\nliposuction O\nin O\nOctober O\nare O\nnot O\nmuch O\nof O\na O\ndeterrent O\n. O\n\nSaldanha B-PER\nsaid O\noperations O\nfell O\n30 O\npercent O\nimmediately O\nafter O\nthat O\ncase O\nbut O\nthe O\nrate O\nwas O\nback O\nto O\nnormal O\nnow O\n. O\n\n-DOCSTART- O\n\nDaily O\nArgentine B-MISC\ngrain O\nfixings O\n- O\nCamaras O\nArbitrales O\n. O\n\nBUENOS B-LOC\nAIRES I-LOC\n1996-12-06 O\n\nAvg O\nDecember O\n5 O\nprice O\nfix O\n: O\n\nBuenos B-LOC\nAires I-LOC\nQuequen B-LOC\nRosario B-LOC\nBahia B-LOC\nBlanca I-LOC\n\nOats O\nunq O\nunq O\nunq O\nunq O\n\nWheat O\n121 O\n130 O\n121.3 O\n121 O\n\nMaize O\n( O\nFlint O\n) O\n113 O\n114 O\n113.7 O\n112 O\n\nMaize O\n( O\nDent O\n) O\n113 O\n114 O\n113.7 O\n112 O\n\nSorghum O\nunq O\nunq O\nunq O\nunq O\n\nMillet O\nunq O\nunq O\n90 O\nunq O\n\nSoybeans O\n283 O\nunq O\n283 O\nunq O\n\nSunseeds O\n219 O\n216 O\n220 O\n216 O\n\n-- O\nBuenos B-ORG\nAires I-ORG\nNewsroom I-ORG\n+541 O\n318-0655 O\n\n-DOCSTART- O\n\nMexican B-MISC\ndaily O\nport O\n, O\nshipping O\nupdate O\nfor O\nDec O\n6 O\n. O\n\nMEXICO B-LOC\nCITY I-LOC\n1996-12-06 O\n\nAll O\nmajor O\nports O\nwere O\nopen O\nas O\nof O\n1000 O\nlocal O\n/ O\n1600 O\nGMT B-MISC\n, O\nthe O\nCommunications B-ORG\nand I-ORG\nTransportation I-ORG\nMinistry I-ORG\nsaid O\nin O\na O\ndaily O\nupdate O\n. O\n\nTampico B-LOC\nport O\nauthorities O\nsaid O\nfishing O\nrestrictions O\nwere O\nin O\nplace O\nin O\nan O\narea O\nadjacent O\nto O\nthe O\nport O\nbecause O\nof O\na O\ngeophysical O\nstudy O\nbeing O\ncarried O\nout O\nin O\ndeep O\nwaters O\nof O\nthe O\nregion O\nfrom O\nthe O\nship O\nKenda B-MISC\n. O\n\nThe O\nministry O\nupdated O\nport O\nconditions O\nand O\nshipping O\nwarnings O\nfor O\nthe O\nGulf B-LOC\nof I-LOC\nMexico I-LOC\n, O\nCaribbean B-LOC\nand O\nPacific B-LOC\nCoast I-LOC\n. O\n\n- O\nPacific B-LOC\nCoast I-LOC\n: O\n\nLight O\nrains O\nalong O\nthe O\ncoast O\nof O\nsouthern O\nBaja B-LOC\nCalifornia I-LOC\nand O\nSinaloa B-LOC\n, O\nwith O\nthe O\nrest O\nof O\nthe O\ncoast O\nseeing O\nclear O\nskies O\n. O\n\nWinds O\nfrom O\nthe O\nnortheast O\nof O\n10 O\nto O\n15 O\nknots O\n( O\n19 O\nto O\n28 O\nkilometers O\n/ O\n11 O\nto O\n17 O\nmiles O\nper O\nhour O\n) O\n. O\n\nA O\nnew O\nfront O\nis O\nseen O\nemerging O\nduring O\nthe O\ncourse O\nof O\nFriday O\n, O\naffecting O\nthe O\nnorth O\nof O\nthe O\nBaja B-LOC\nCalifornia I-LOC\npeninsula O\nand O\nSonora B-LOC\nstate O\n, O\nbringing O\nlower O\ntemperatures O\n, O\nlight O\nrains O\nand O\nwaves O\nup O\nto O\nsix O\nfeet O\n. O\n\n- O\nGulf B-LOC\nof I-LOC\nMexico I-LOC\n: O\n\nCold O\nfront O\nbringing O\nlight O\nrains O\nto O\nthe O\ncoast O\nof O\nTamaulipas B-LOC\n, O\nbut O\nwith O\nthe O\nrest O\nof O\nthe O\nGulf B-LOC\nin O\nclear O\nskies O\n. O\n\nWinds O\nfrom O\nthe O\nnortheast O\nat O\n10 O\nto O\n15 O\nknots O\n( O\n19 O\nto O\n28 O\nkilometers O\n/ O\n11 O\nto O\n17 O\nmiles O\nper O\nhour O\n) O\n. O\n\n- O\nCaribbean B-LOC\n: O\n\nTropical O\nair O\ncarrying O\nsporadic O\nlight O\nrains O\nover O\nthe O\ncoast O\nof O\nQuintana B-LOC\nRoo I-LOC\nstate O\n. O\n\nWinds O\nfrom O\nthe O\nnortheast O\nat O\n10 O\nto O\n15 O\nknots O\nwith O\nwaves O\nthree O\nto O\nfive O\nfeet O\nhigh O\n. O\n\n-- O\nChris B-PER\nAspin I-PER\n, O\nMexico B-LOC\nCity I-LOC\nnewsroom O\n+525 O\n728-7903 O\n\n-DOCSTART- O\n\nBrazil B-LOC\nexam O\ncheats O\ncaught O\nusing O\n\" O\npager O\n\" O\nwatches O\n. O\n\nRIO B-LOC\nDE I-LOC\nJANEIRO I-LOC\n1996-12-06 O\n\nBrazilian B-MISC\nstudents O\nhave O\nbeen O\ncaught O\ncheating O\nin O\nuniversity O\nentrance O\nexams O\nby O\nusing O\ndigital O\nwatches O\nwhich O\ngave O\nthe O\ncorrect O\nanswers O\nto O\ntest O\nquestions O\n, O\na O\nnewspaper O\nsaid O\non O\nFriday O\n. O\n\nRio B-LOC\nde I-LOC\nJaneiro I-LOC\nstate O\nuniversity O\nofficials O\ndiscovered O\nstudents O\nwere O\npaying O\n15,000 O\nreais O\n( O\n$ O\n14,563 O\n) O\nfor O\nthe O\nspecial O\nwatches O\n, O\nwhich O\noperated O\nlike O\na O\ntelephone O\npager O\nto O\nreceive O\ncorrect O\nanswers O\n, O\nO B-ORG\nGlobo I-ORG\nsaid O\n. O\n\nSeventy-seven O\nstudents O\nwere O\nfound O\nwith O\nthe O\nwatches O\nand O\ndisqualified O\n, O\nO B-ORG\nGlobo I-ORG\nsaid O\n. O\n\n-DOCSTART- O\n\nChile B-LOC\n, O\nMexico B-LOC\nto O\nseek O\nto O\nbroaden O\ntrade O\ndeal O\n. O\n\nSANTIAGO B-PER\n1996-12-05 O\n\nChile B-LOC\nand O\nMexico B-LOC\nwill O\nstart O\nnegotiations O\nnext O\nyear O\nto O\nbroaden O\ntheir O\nfree O\ntrade O\nagreement O\nto O\ninclude O\nservices O\nand O\ninvestments O\n, O\nFinance B-ORG\nMinister O\nEduardo B-PER\nAninat I-PER\nsaid O\n. O\n\nChile B-LOC\nhopes O\nto O\nbroaden O\nthe O\ntreaty O\nsigned O\nin O\n1994 O\nbeyond O\nreduction O\nof O\ntariffs O\non O\nimports O\nand O\nexports O\nand O\nadd O\nprovisions O\ncovering O\nservices O\nand O\ninvestment O\ncodes O\n, O\nsaid O\nAninat B-PER\n. O\n\nBoth O\nareas O\ntend O\nto O\nmore O\nladen O\nwith O\nfriction O\nin O\nfree O\ntrade O\nnegotiations O\nthan O\ntariff O\nreduction O\n. O\n\n' O\n' O\nIn O\nJanuary O\nor O\nFebruary O\n, O\nwe O\n'll O\nhave O\nsome O\nvery O\nclose O\ncontacts O\nwith O\nMexico B-LOC\nto O\nadd O\nthe O\nissue O\nof O\nservices O\nand O\nadvance O\non O\nthe O\nissue O\nof O\ninvestments O\n, O\n' O\n' O\nAninat B-PER\ntold O\nreporters O\nafter O\nsigning O\na O\nfree O\ntrade O\ndeal O\nwith O\nCanada B-LOC\n. O\n\n' O\n' O\nWe O\nwant O\nto O\ngive O\nthe O\ntreaty O\nbetween O\nMexico B-LOC\nand O\nChile B-LOC\ngreater O\ndepth O\nand O\ncoverage O\nthan O\nit O\nhas O\nnow O\n. O\n\nIt O\n's O\nvery O\ngood O\nnow O\n, O\nbut O\nit O\npractically O\nonly O\ncovers O\ntrade O\nin O\ngoods O\n, O\n' O\n' O\nhe O\nsaid O\n. O\n\nAninat B-PER\nalso O\nsaid O\nhe O\nwas O\nconfident O\nthe O\nChilean B-MISC\nCongress O\nwould O\nratify O\nthe O\ntreaty O\nwith O\nCongress O\nquickly O\n. O\n\n' O\n' O\nThe O\nreactions O\nfrom O\nbusiness O\nand O\nunions O\nwhich O\nI O\nhave O\nseen O\nhave O\nbeen O\nalmost O\nunanimously O\npositive O\n, O\nso O\nI O\ndo O\nn't O\nsee O\nany O\nproblem O\n, O\n' O\n' O\nhe O\nsaid O\n. O\n\n-- O\nRoger B-PER\nAtwood I-PER\n, O\nSantiago B-LOC\nnewsroom O\n+56-2-699-5595 O\nx211 O\n\n-DOCSTART- O\n\nIndonesia B-LOC\n's O\nBelo B-PER\nleaves O\nfor O\nNobel B-MISC\naward O\nceremony O\n. O\n\nDILI B-LOC\n, O\nEast B-LOC\nTimor I-LOC\n1996-12-06 O\n\nEast B-MISC\nTimorese I-MISC\nRoman B-MISC\nCatholic I-MISC\nBishop O\nCarlos B-PER\nBelo I-PER\nleft O\nDili B-LOC\non O\nFriday O\non O\nhis O\nway O\nto O\nNorway B-LOC\nfor O\nthe O\nawards O\nceremony O\nas O\nco-recipient O\nof O\nthe O\n1996 O\nNobel B-MISC\nPeace I-MISC\nPrize I-MISC\n. O\n\nWitnesses O\nsaid O\nBelo B-PER\nleft O\nthe O\nterritory O\nfor O\nthe O\nIndonesian B-MISC\ncapital O\nJakarta B-LOC\naccompanied O\nby O\nfive O\nother O\npeople O\n. O\n\nIt O\nwas O\nnot O\nimmediately O\nknown O\nwhen O\nhe O\nwould O\narrive O\nin O\nOslo B-LOC\n. O\n\nThe O\nbishop O\nwill O\njointly O\nreceive O\nthe O\nNobel B-MISC\naward O\nnext O\nTuesday O\nwith O\nEast B-MISC\nTimorese-born I-MISC\nactivist O\nJose B-PER\nRamos I-PER\nHorta I-PER\n, O\nwho O\nlives O\nin O\nself-exile O\nin O\nAustralia B-LOC\n. O\n\nThe O\nIndonesian B-MISC\ngovernment O\nhas O\ncondemned O\nthe O\ninclusion O\nof O\nRamos B-PER\nHorta I-PER\nin O\nthe O\naward O\n, O\nand O\nForeign O\nMinister O\nAli B-PER\nAlatas I-PER\nsaid O\non O\nFriday O\nthat O\nIndonesia B-LOC\nwould O\nnot O\nbe O\nrepresented O\nofficially O\nat O\nthe O\nceremony O\nin O\nthe O\nNorwegian B-MISC\ncapital O\n. O\n\n\" O\nI O\nsincerely O\nbelieve O\nthat O\nthis O\nunfortunate O\nchoice O\nin O\ngiving O\nthe O\nhonour O\nto O\nsuch O\na O\ncontroversial O\nfigure O\nas O\nRamos B-PER\nHorta I-PER\n... O\n\nwill O\nexacerbate O\nthe O\nproblem O\nin O\nfinding O\na O\nsolution O\n( O\nto O\nEast B-LOC\nTimor I-LOC\n) O\n, O\n\" O\nAlatas B-PER\nsaid O\non O\nFriday O\n. O\n\nHe O\nwas O\nresponding O\nto O\nquestions O\nat O\na O\nnews O\nconference O\ncalled O\nto O\ndiscuss O\nnext O\nweek O\n's O\nministerial O\nmeeting O\nof O\nthe O\nOrganisation B-ORG\nof I-ORG\nthe I-ORG\nIslamic I-ORG\nConference I-ORG\n( O\nOIC B-ORG\n) O\nin O\nJakarta B-LOC\n. O\n\nRamos B-PER\nHorta I-PER\nhas O\nbeen O\na O\nvocal O\nleader O\nof O\nthe O\nopposition O\nto O\nJakarta B-LOC\n's O\nrule O\nin O\nthe O\nterritory O\n. O\n\nBelo B-PER\nand O\nRamos B-PER\nHorta I-PER\nwere O\nawared O\nthe O\nprize O\nfor O\ntheir O\nefforts O\nto O\nsecure O\na O\npeaceful O\nsolution O\nto O\nthe O\nissue O\nof O\nEast B-LOC\nTimor I-LOC\n, O\na O\nformer O\nPortuguese B-MISC\ncolony O\nwhich O\nIndonesia B-LOC\ninvaded O\nin O\n1975 O\nand O\nannexed O\nthe O\nfollowing O\nyear O\n. O\n\nThe O\nUnited B-ORG\nNations I-ORG\nhas O\nnever O\nrecognised O\nJakarta B-LOC\n's O\nmove O\n. O\n\nAlatas B-PER\nsaid O\nthe O\ngovernment O\n's O\nposition O\non O\nthe O\nNobel B-MISC\nPeace I-MISC\nPrize I-MISC\nwould O\nhave O\nbeen O\ndifferent O\nif O\nit O\nhad O\nbeen O\nawarded O\nsolely O\nto O\nBelo B-PER\n. O\n\nAsked O\nif O\nthe O\nIndonesian B-MISC\nambassador O\nto O\nNorway B-LOC\nwould O\nhave O\nattended O\nthe O\nceremony O\nif O\nonly O\nBelo B-PER\nhad O\nbeen O\ninvolved O\n, O\nAlatas B-PER\nreplied O\n: O\n\" O\nProbably O\n, O\nyes O\n, O\nbut O\nthat O\nis O\na O\nhypothetical O\nquestion O\n. O\n\" O\n\nAlatas B-PER\nsaid O\non O\nTuesday O\nthat O\non O\nhis O\nway O\nback O\nfrom O\nOslo B-LOC\n, O\nBelo B-PER\nwould O\nvisit O\nthe O\nVatican B-LOC\nto O\nsee O\nthe O\nPope O\n, O\nand O\nwould O\nalso O\nmeet O\nGerman B-MISC\nChancellor O\nHelmut B-PER\nKohl I-PER\nin O\nBonn B-LOC\n. O\n\nKohl B-PER\nhad O\nwanted O\nto O\nmeet O\nBelo B-PER\nduring O\nthe O\nchancellor O\n's O\nofficial O\nvisit O\nto O\nIndonesia B-LOC\nlast O\nmonth O\n, O\nbut O\nthe O\nbishop O\nwas O\ntoo O\nbusy O\nin O\nEast B-LOC\nTimor I-LOC\nto O\ncome O\nto O\nJakarta B-LOC\n. O\n\n-DOCSTART- O\n\nChina B-LOC\nto O\nopen O\nport O\nin O\nHainan B-LOC\nto O\nforeign O\nships O\n. O\n\nBEIJING B-LOC\n1996-12-06 O\n\nChina B-LOC\n's O\nState B-ORG\nCouncil I-ORG\n, O\nor O\ncabinet O\n, O\nhas O\ngiven O\na O\nport O\nin O\nthe O\nsouthern O\nprovince O\nof O\nHainan B-LOC\npermission O\nto O\nopen O\nto O\nforeign O\nvessels O\n, O\nthe O\nXinhua B-ORG\nnews O\nagency O\nsaid O\non O\nFriday O\n. O\n\nXinhua B-ORG\ndid O\nnot O\nsay O\nwhen O\nQinglan B-LOC\nport O\nin O\nWenchang B-LOC\ncity O\nwould O\nbe O\nopened O\nto O\nforeign O\nvessels O\n. O\n\nWenchang B-LOC\nhas O\nbuilt O\na O\nberth O\nfor O\n5,000 O\ndeadweight-tonne O\ncontainer O\nships O\nat O\nthe O\nport O\nand O\ninvested O\n34 O\nmillion O\nyuan O\n( O\n$ O\n4.1 O\nmillion O\n) O\nto O\ndredge O\nthe O\nharbour O\n, O\nXinhua B-ORG\nsaid O\n. O\n\nIt O\ngave O\nno O\nfurther O\ndetails O\n. O\n\n( O\n$ O\n1 O\n= O\n8.3 O\nyuan O\n) O\n\n-DOCSTART- O\n\nGovernment O\ndisperses O\nprotest O\nwith O\nwater O\ncannons O\n. O\n\nRANGOON B-LOC\n1996-12-07 O\n\nBurmese B-MISC\ntroops O\nand O\nriot O\npolice O\nmoved O\nin O\nto O\ndisperse O\na O\nstudent O\nstreet O\nprotest O\nat O\na O\nsuburban O\nroad O\njunction O\nnear O\nthe O\nRanyon B-ORG\n( I-ORG\nRangoon I-ORG\n) I-ORG\nUniversity I-ORG\nearly O\non O\nSaturday O\n, O\nwitnesses O\nsaid O\n. O\n\nThey O\nsaid O\npolice O\nand O\ntroops O\nused O\nwater O\ncannons O\nfrom O\nfire O\nengines O\nto O\nsubdue O\nabout O\n120 O\nuniversity O\nstudents O\nsitting O\nin O\nat O\nthe O\ncentre O\nof O\nthe O\njunction O\nat O\nabout O\n3 O\na.m. O\nbefore O\nthey O\nmoved O\nin O\nto O\nround O\nthem O\nup O\n. O\n\nThe O\nstudents O\n, O\nwho O\nhad O\nstaged O\nan O\n11-hour O\nprotest O\nat O\nthe O\njunction O\nin O\nnorthern O\nRangoon B-LOC\n, O\nwere O\ntaken O\naway O\nin O\nthree O\nvehicles O\n. O\n\nThe O\nwitnesses O\nsaid O\nsome O\nof O\nthe O\nstudents O\nwere O\nhit O\nwith O\nbatons O\nwhile O\nthey O\nwere O\nherded O\nonto O\nthe O\nvehicles O\nand O\nit O\nwas O\nbelieved O\nthey O\nwere O\ntaken O\nto O\nthe O\nInsein B-LOC\nprison O\nin O\nsuburban O\nRangoon B-LOC\n. O\n\nThe O\nprotesting O\nstudents O\n, O\nmostly O\nfrom O\nRangoon B-ORG\nUniversity I-ORG\n, O\nwere O\ndemanding O\nthe O\nright O\nto O\norganise O\nindependent O\nunions O\non O\ncampuses O\nand O\nthe O\nrelease O\nof O\nabout O\n80 O\nstudent O\nleaders O\ncurrently O\nin O\njail O\n. O\n\nThey O\nwere O\namong O\n500 O\nstudents O\nwho O\nstarted O\ndemonstrating O\nat O\nthe O\nintersection O\non O\nlate O\nFriday O\nafternoon O\n. O\n\nThe O\nprotest O\nwas O\nthe O\nsecond O\nmajor O\none O\nin O\nfive O\ndays O\nin O\nthe O\ncapital O\n. O\n\n-DOCSTART- O\n\nBurmese B-MISC\nstudents O\nmarch O\nbriefly O\nout O\nof O\ncampus O\n. O\n\nVithoon B-PER\nAmorn I-PER\n\nRANGOON B-LOC\n1996-12-06 O\n\nAbout O\n200 O\nBurmese B-MISC\nstudents O\nmarched O\nbriefly O\nfrom O\ntroubled O\nYangon B-ORG\nInstitute I-ORG\nof I-ORG\nTechnology I-ORG\nin O\nnorthern O\nRangoon B-LOC\non O\nFriday O\ntowards O\nthe O\nUniversity B-ORG\nof I-ORG\nYangon I-ORG\nsix O\nkm O\n( O\nfour O\nmiles O\n) O\naway O\n, O\nand O\nreturned O\nto O\ntheir O\ncampus O\n, O\nwitnesses O\nsaid O\n. O\n\nSeven O\ntruckloads O\nof O\narmed O\nriot O\npolice O\nand O\nthree O\nfire O\nengines O\nwere O\non O\nstandby O\nat O\none O\nof O\nthe O\njunctions O\nnear O\nthe O\ninstitute O\n. O\n\nThere O\nwere O\nno O\nclashes O\n. O\n\n\" O\nThey O\nare O\nnow O\nback O\nin O\nthe O\nYIT B-ORG\ncampus O\n, O\n\" O\nan O\ninstitute O\nofficial O\nwho O\ndeclined O\nto O\nbe O\nidentified O\ntold O\nReuters B-ORG\nby O\ntelephone O\n. O\n\nOne O\nof O\ntwo O\nroads O\nleading O\nto O\nthe O\nUniversity B-ORG\nof I-ORG\nYangon I-ORG\nfrom O\nthe O\ninstitute O\nhad O\nbeen O\nclosed O\nby O\nauthorities O\n. O\n\nBut O\nabout O\n300 O\nuniversity O\nstudents O\nwere O\nstill O\ngathered O\noutside O\nthe O\ngates O\nof O\ntheir O\ncampus O\n, O\nwitnesses O\nsaid O\n. O\n\nThey O\nwere O\nsinging O\npeacefully O\n. O\n\nOn O\nMonday O\nand O\nTuesday O\n, O\nstudents O\nfrom O\nthe O\ninstitute O\nand O\nthe O\nuniversity O\nlaunched O\nprotests O\nagainst O\nwhat O\nthey O\nsaid O\nwas O\nunfair O\nhandling O\nby O\npolice O\nof O\na O\nbrawl O\nbetween O\nsome O\nof O\ntheir O\ncolleagues O\nand O\nrestaurant O\nowners O\nin O\nOctober O\n. O\n\nOn O\nTuesday O\nand O\nWednesday O\n, O\nopposition O\nleader O\nAung B-PER\nSan I-PER\nSuu I-PER\nKyi I-PER\nwas O\nrestricted O\nto O\nher O\nhome O\nby O\nthe O\nmilitary O\ngovernment O\nto O\nprevent O\nher O\nfrom O\nbeing O\ndrawn O\ninto O\nthe O\nprotests O\n. O\n\nShe O\nwas O\nallowed O\nto O\nmove O\nfreely O\non O\nThursday O\n. O\n\nThe O\nprotest O\nculminated O\nat O\ndawn O\non O\nTuesday O\nwith O\nseveral O\nhundred O\nstudents O\nbeing O\ndetained O\nbriefly O\nby O\npolice O\nin O\ncentral O\nRangoon B-LOC\n. O\n\nThe O\nstreet O\nprotests O\nwere O\nthe O\nbiggest O\nseen O\nin O\nthe O\ncapital O\nsince O\nthe O\nstudent-led O\npro-democracry O\ndemonstrations O\nof O\nSeptember O\n1988 O\nwhen O\nthe O\njunta O\ncrushed O\nthe O\nuprising O\n. O\n\nThousands O\nwere O\nkilled O\nor O\nimprisoned O\n. O\n\nEarlier O\non O\nFriday O\nsome O\nof O\nthe O\nstudents O\n, O\nwho O\nwere O\nheld O\nbriefly O\nby O\npolice O\nduring O\nthe O\nprotests O\nearlier O\nthis O\nweek O\n, O\nsaid O\nthey O\nwere O\nstill O\ndissatisfied O\nwith O\nthe O\nmilitary O\ngovernment O\n. O\n\nThey O\ntold O\nReuters B-ORG\nthey O\nwere O\nunhappy O\nthat O\nthe O\nruling O\nState B-ORG\nLaw I-ORG\nand I-ORG\nOrder I-ORG\nRestoration I-ORG\nCouncil I-ORG\n( O\nSLORC B-ORG\n) O\nhad O\nnot O\nheeded O\ntheir O\ncalls O\nfor O\nthe O\nright O\nto O\norganise O\nindependent O\nunions O\non O\ncampus O\n. O\n\n\" O\nWe O\nstill O\nwant O\ngovernment O\nanswers O\nto O\nour O\ndemands O\n. O\n\nWe O\nwant O\npolice O\npunishment O\nto O\nbe O\npublished O\nin O\nnewspapers O\n, O\n\" O\none O\nstudent O\nsaid O\n. O\n\nBut O\nthe O\nstudents O\nstressed O\ntheir O\nprotests O\nwere O\nnon-political O\nand O\nthey O\nhad O\nno O\ncontact O\nwith O\nSuu B-PER\nKyi I-PER\n's O\nNational B-ORG\nLeague I-ORG\nfor I-ORG\nDemocracy I-ORG\n( O\nNLD B-ORG\n) O\n. O\n\nSuu B-PER\nKyi I-PER\n, O\na O\nNobel B-MISC\nlaureate O\nand O\ndaughter O\nof O\nindependence O\nhero O\nAung B-PER\nSan I-PER\n, O\nand O\nkey O\nNLD B-ORG\nofficials O\nhave O\nalso O\ndenied O\nany O\nlink O\nwith O\nthe O\nstudents O\n. O\n\nBut O\nthey O\nhave O\nsaid O\nboth O\nparties O\nhad O\na O\n\" O\nmoral O\nlink O\n\" O\nin O\nthat O\nthey O\nwere O\nagainst O\npolice O\nbrutality O\nand O\ninjustice O\n. O\n\nThe O\nstudents O\nalso O\ndemanded O\nthe O\ngovernment O\nannounce O\npunishments O\nmeted O\nout O\nto O\npolicemen O\nwho O\nthey O\nsaid O\nhad O\nmanhandled O\nstudents O\ninvolved O\nin O\na O\nbrawl O\nwith O\nsome O\nrestaurant O\nowners O\nnear O\nthe O\nYangon B-LOC\ninstitute O\nin O\nOctober O\n. O\n\nThe O\nstudents O\nappealed O\nto O\nthe O\ngovernment O\nnot O\nto O\nclose O\nthe O\ninstitute O\nbecause O\nof O\ntheir O\nlatest O\ndemonstration O\n. O\n\nThe O\ninstitute O\nwas O\nshut O\nfor O\nnearly O\ntwo O\nyears O\nafter O\nthe O\n1988 O\nuprising O\n. O\n\nOn O\nFriday O\n, O\nthe O\nroad O\nleading O\nto O\nSuu B-PER\nKyi I-PER\n's O\nlakeside O\nresidence O\nin O\ncentral O\nRangoon B-LOC\nremained O\nclosed O\nby O\npolice O\n. O\n\n-DOCSTART- O\n\nUnion O\nleaders O\noutraged O\nby O\nWTO B-ORG\nsnub O\nto O\nILO B-ORG\nhead O\n. O\n\nSINGAPORE B-LOC\n1996-12-06 O\n\nInternational O\ntrade O\nunion O\nleaders O\non O\nFriday O\nexpressed O\noutrage O\nthat O\nthe O\nhead O\nof O\nthe O\nInternational B-ORG\nLabour I-ORG\nOrganisation I-ORG\n( O\nILO B-ORG\n) O\nhad O\nbeen O\nbarred O\nfrom O\nspeaking O\nat O\nnext O\nweek O\n's O\nWTO B-ORG\nmeeting O\nin O\nSingapore B-LOC\n. O\n\nBill B-PER\nJordan I-PER\n, O\ngeneral O\nsecretary O\nof O\nthe O\nInternational B-ORG\nConfederation I-ORG\nof I-ORG\nFree I-ORG\nTrade I-ORG\nUnions I-ORG\n( O\nICFTU B-ORG\n) O\n, O\ntold O\na O\nnews O\nconference O\nthe O\nwithdrawal O\nof O\na O\nWTO B-ORG\ninvitation O\nto O\nILO B-ORG\ndirector O\ngeneral O\nMichel B-PER\nHansenne I-PER\nwas O\n\" O\noutrageous O\nbehaviour O\non O\nthe O\npart O\nof O\nan O\norganisation O\nthat O\nwants O\nto O\ncommand O\nrespect O\nin O\nthe O\nworld O\n\" O\n. O\n\nJordan B-PER\nsaid O\na O\nsmall O\ngroup O\nof O\ndeveloping O\nnations O\nthat O\noppose O\nlinking O\ntrade O\ntalks O\nand O\nlabour O\nconditions O\nhad O\npressured O\nWorld B-ORG\nTrade I-ORG\nOrganisation I-ORG\n( O\nWTO B-ORG\n) O\nofficials O\nto O\nprevent O\nHansenne O\nfrom O\ntaking O\nthe O\nplatform O\nto O\nurge O\nsuch O\nlinks O\n. O\n\n\" O\nIt O\nis O\nto O\ntheir O\nshame O\nthat O\nthose O\nwho O\nare O\nresponsible O\nfor O\nencouraging O\nthis O\nmeeting O\nresponded O\n( O\nto O\nthe O\npressure O\n) O\nin O\nsilencing O\nhim O\n, O\n\" O\nJordan B-PER\nsaid O\nafter O\nthe O\nopening O\nof O\nan O\nICFTU B-ORG\nconference O\non O\ninternational O\nlabour O\nstandards O\nand O\ntrade O\n. O\n\nThe O\nthree-day O\ntrade O\nunion O\nconference O\nin O\nSingapore B-LOC\nhopes O\nto O\npush O\nlabour O\nissues O\nonto O\nthe O\nWTO B-ORG\nagenda O\n. O\n\nJordan B-PER\nsaid O\nthe O\nWTO B-ORG\n's O\ncredibility O\nwas O\nat O\nstake O\nover O\nthe O\nissue O\nof O\ntrade O\nand O\nlabour O\n. O\n\nThe O\nICFTU B-ORG\nsaid O\nit O\nwanted O\nthe O\nWTO B-ORG\nconference O\nbeginning O\non O\nMonday O\nto O\noutlaw O\nforced O\nand O\nchild O\nlabour O\n, O\nend O\ndiscrimination O\nin O\nhiring O\n, O\nand O\nguarantee O\nthe O\nright O\nto O\njoin O\na O\nunion O\n. O\n\nBill B-PER\nBrett I-PER\n, O\nchairman O\nof O\nthe O\nILO B-ORG\nWorkers I-ORG\nGroup I-ORG\n, O\ntold O\nReuters B-ORG\nbefore O\nthe O\nnews O\nconference O\nhe O\nwas O\n\" O\nnot O\ntoo O\nsurprised O\n, O\nbut O\nvery O\ndisappointed O\n\" O\nthat O\nthe O\nspeaking O\ninvitation O\nhad O\nbeen O\nwithdrawn O\n. O\n\n\" O\nSome O\ngovernments O\nare O\nvery O\ndetermined O\nto O\nstop O\nthe O\nissue O\n( O\nof O\ntrade O\nand O\nlabour O\nrights O\n) O\nbeing O\ndiscussed O\n, O\n\" O\nhe O\nsaid O\n, O\nadding O\nthat O\nthe O\nAssociation B-ORG\nof I-ORG\nSoutheast I-ORG\nAsian I-ORG\nNations I-ORG\n( O\nASEAN B-ORG\n) O\nseemed O\nparticularly O\nhostile O\nto O\nthe O\nILO B-ORG\nagenda O\n. O\n\nASEAN B-ORG\ngroups O\nBrunei B-LOC\n, O\nIndonesia B-LOC\n, O\nMalaysia B-LOC\n, O\nthe O\nPhilippines B-LOC\n, O\nSingapore B-LOC\n, O\nThailand B-LOC\nand O\nVietnam B-LOC\n. O\n\nThe O\nILO B-ORG\nwants O\na O\ntrade O\nand O\nlabour O\nrights O\n\" O\nsocial O\nclause O\n\" O\nincluded O\nin O\nthe O\nfinal O\nministerial O\nstatement O\nissued O\nby O\nWTO B-ORG\nleaders O\nat O\nthe O\nend O\nof O\nthe O\nmeeting O\n, O\nthe O\norganization O\n's O\nfirst O\nministerial-level O\ngathering O\n. O\n\nSpeaking O\nto O\nICFTU B-ORG\ndelegates O\n, O\nRichard B-PER\nEglin I-PER\n, O\ndirector O\nof O\nthe O\nWTO B-ORG\nsecretariat O\n, O\nsaid O\nthe O\nWTO B-ORG\nwas O\ncapable O\nof O\nmaking O\na O\nsignificant O\ncontribution O\nto O\ngovernmental O\nefforts O\nto O\nsolve O\nsocial O\nproblems O\n. O\n\nBut O\nhe O\nsaid O\nthe O\nWTO B-ORG\n's O\norganisational O\nstructure O\nmade O\nit O\ndifficult O\nto O\nimpose O\non O\nits O\nmembers O\na O\nsocial O\nclause O\nsuch O\nas O\nthat O\ncalled O\nfor O\nby O\nthe O\nILO B-ORG\n. O\n\n-DOCSTART- O\n\nIndian B-MISC\nrubber O\ndemand O\nseen O\noutstripping O\nproduction O\n. O\n\nSINGAPORE B-LOC\n1996-12-06 O\n\nIndian B-MISC\nrubber O\ndemand O\nis O\nseen O\noutpacing O\nlocal O\nproduction O\nin O\nthe O\n1996/97 O\nApril O\n/ O\nMarch O\nseason O\nand O\nthe O\ntrend O\nwill O\npersist O\nway O\ninto O\nthe O\nnext O\ncentury O\n, O\nthe O\nchairman O\nof O\nthe O\nRubber B-ORG\nBoard I-ORG\nof I-ORG\nIndia I-ORG\nsaid O\non O\nFriday O\n. O\n\nK.J. B-PER\nMatthew I-PER\nsaid O\nat O\nthe O\nAsia B-MISC\nRubber I-MISC\nMarkets I-MISC\nmeeting I-MISC\nhere O\nIndian B-MISC\nproduction O\nof O\nnatural O\nrubber O\nin O\n1996/97 O\nwill O\nreach O\n547,000 O\ntonnes O\nagainst O\nprojected O\ndemand O\nof O\n578,000 O\ntonnes O\n, O\na O\ngap O\nof O\n31,000 O\ntonnes O\n. O\n\nFor O\nsynthetic O\nrubber O\n, O\nproduction O\nreached O\n68,200 O\ntonnes O\nin O\n1995/96 O\nwhile O\nconsumption O\nin O\nthe O\nsame O\nseason O\nhit O\n134,085 O\ntonnes O\n, O\nMatthew B-PER\nadded O\n. O\n\n\" O\nThough O\nschemes O\ndesigned O\nto O\nrealise O\nfurther O\nincreases O\nin O\nthe O\nproduction O\nof O\nnatural O\nrubber O\nare O\nbeing O\noperated O\nsuccessfully O\n, O\nthe O\ndemand-supply O\ngap O\nis O\nexpected O\nto O\nwiden O\n, O\n\" O\nhe O\nsaid O\n. O\n\nIndian B-MISC\nsynthetic O\nrubber O\noutput O\nis O\nnot O\nexpected O\nto O\nrise O\nsignificantly O\nin O\nthe O\nnext O\nseason O\nbut O\ndemand O\nwill O\nrise O\nto O\n145,000 O\ntonnes O\n. O\n\nMatthew B-PER\nestimates O\nthat O\nby O\nthe O\n2000/01 O\nseason O\n, O\nthe O\ngap O\nbetween O\nnatural O\nrubber O\noutput O\nand O\nconsumption O\nwill O\nrise O\nto O\n51,000 O\ntonnes O\nand O\n319,000 O\ntonnes O\nin O\n2010/11 O\n. O\n\nNatural O\nrubber O\nproduction O\nwill O\ngo O\nup O\nto O\n695,000 O\ntonnes O\nin O\n2000/01 O\nagainst O\nconsumption O\nof O\n746,000 O\ntonnes O\n. O\n\nIn O\n2010/11 O\n, O\ndomestic O\ndemand O\nshould O\nrise O\nfurther O\nto O\n1.233 O\nmillion O\ntonnes O\nwhile O\nproduction O\nwill O\nonly O\nreach O\nabout O\n914,000 O\ntonnes O\n. O\n\nOne O\nway O\nto O\nbridge O\nthe O\nwidening O\ngap O\nis O\nto O\nput O\nmore O\nland O\nunder O\ncultivation O\nwhich O\nthe O\nRubber B-ORG\nBoard I-ORG\nofficial O\nestimates O\nwill O\nreach O\n220,000 O\nhectares O\nbetween O\nnow O\nand O\nthe O\nyear O\n2003 O\nalthough O\nMatthew B-PER\nsaid O\nthis O\nmay O\nnot O\nbe O\npossible O\nat O\nthis O\ntime O\nin O\nIndia B-LOC\n. O\n\n\" O\nThe O\ndevelopment O\nobjective O\nfor O\nthe O\nrubber O\nplantation O\nindustry O\nwill O\nbe O\nto O\nincrease O\nproduction O\nto O\nthe O\nbest O\nextent O\npossibly O\nwith O\na O\nview O\nto O\nminimising O\nimports O\nof O\nnatural O\nrubber O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-- O\nSingapore B-ORG\nNewsroom I-ORG\n( O\n65-8703305 O\n) O\n\n-DOCSTART- O\n\nJapan B-LOC\n's O\nauthorities O\nseen O\nseeking O\nto O\nrein O\nin O\ndollar O\n. O\n\nGeorge B-PER\nNishiyama I-PER\n\nTOKYO B-LOC\n1996-12-06 O\n\nComments O\nby O\nJapan B-LOC\n's O\ntight-lipped O\ncentral O\nbank O\nchief O\nand O\nan O\ninfluential O\ntop O\nbureaucrat O\nare O\nfurther O\nsigns O\nthat O\nthe O\nnation O\n's O\nauthorities O\nwant O\nto O\nkeep O\nthe O\ndollar O\nat O\ncurrent O\nlevels O\n, O\nmarket O\nsources O\nsaid O\non O\nFriday O\n. O\n\nIn O\na O\nrare O\nexpression O\nof O\na O\nview O\non O\ncurrencies O\nby O\nthe O\nBank B-ORG\nof I-ORG\nJapan I-ORG\n( O\nBOJ B-ORG\n) O\ngovernor O\n, O\nYasuo B-PER\nMatsushita I-PER\nwas O\nquoted O\nin O\nJapan B-LOC\n's O\nleading O\neconomic O\ndaily O\non O\nFriday O\nas O\nsaying O\nthat O\nhe O\nsees O\nno O\nfurther O\n, O\nimmediate O\nfall O\nin O\nthe O\nyen O\n. O\n\nThis O\nfollowed O\na O\nwidely O\nwatched O\ntelevision O\nappearance O\nlate O\non O\nThursday O\nby O\nEisuke B-PER\nSakakibara I-PER\n, O\na O\nhigh-ranking O\nFinance B-ORG\nMinistry I-ORG\nofficial O\n, O\nwho O\ndenied O\nhe O\nhad O\nsaid O\nhe O\nwants O\nto O\nguide O\nthe O\ndollar O\nlower O\nto O\nbetween O\n108 O\nand O\n110 O\nyen O\n. O\n\nBut O\nmany O\nin O\nthe O\nmarket O\nthought O\nSakakibara B-PER\n's O\nreal O\nintentions O\nlay O\nelsewhere O\n, O\nand O\ntook O\nmore O\nnotice O\nof O\nhis O\ncomments O\nabout O\nthe O\nU.S. B-LOC\ngovernment O\n's O\nstance O\non O\nthe O\ndollar O\n, O\ndealers O\nsaid O\n. O\n\n\" O\nI O\nthink O\nhis O\nviews O\non O\n( O\nU.S. B-ORG\nTreasury I-ORG\nSecretary O\nRobert B-PER\n) O\nRubin B-PER\n's O\ncomments O\nwere O\nindeed O\nwhat O\nhe O\nhimself O\nthinks O\nabout O\nthe O\ndollar O\n, O\n\" O\nsaid O\nHank B-PER\nNote I-PER\n, O\nchief O\ndealer O\nat O\nSumitomo B-ORG\nBank I-ORG\n. O\n\nAsked O\nabout O\nRubin B-PER\n's O\ncomment O\nthat O\na O\nstrong O\ndollar O\nwas O\nin O\nU.S. B-LOC\ninterests O\n, O\nSakakibara B-PER\nsaid O\nthe O\nremark O\ndoes O\nnot O\nnecessarily O\nmean O\nthe O\nUnited B-LOC\nStates I-LOC\nsupports O\na O\nstronger O\ndollar O\n. O\n\n\" O\nIt O\n's O\na O\nstrong O\ndollar O\n, O\nnot O\nstronger O\n. O\n\nIn O\nthat O\nsense O\n, O\nthe O\ncomments O\nare O\nnot O\npointing O\nto O\na O\ncertain O\ndirection O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nIt O\nshows O\nthat O\nSakakibara B-PER\nis O\nnot O\nfor O\na O\nstronger O\ndollar O\neither O\n, O\n\" O\nsaid O\nSumitomo B-ORG\n's O\nNote B-PER\n. O\n\nTakao B-PER\nSakoh I-PER\n, O\nfirst O\nvice O\npresident O\nat O\nUnion B-ORG\nBank I-ORG\nof I-ORG\nSwitzerland I-ORG\nin O\nTokyo B-LOC\n, O\nsaid O\n: O\n\" O\nMaybe O\na O\ndollar O\nat O\n104.50 O\nyen O\nis O\nnot O\nacceptable O\n( O\nto O\nSakakibara B-PER\n) O\n, O\nbut O\nit O\nmay O\nbe O\nokay O\nat O\nthe O\ncurrent O\nlevel O\n, O\nat O\nthe O\nlower O\nend O\nof O\n112 O\nyen O\n. O\n\" O\n\nMarket O\nparticipants O\nhave O\nkept O\na O\nclose O\neye O\non O\nSakakibara B-PER\n, O\nchief O\nof O\nthe O\nministry O\n's O\nInternational B-ORG\nFinance I-ORG\nBureau I-ORG\n, O\nas O\na O\ncomment O\nhe O\nmade O\nin O\nNovember O\nafter O\nthe O\ndollar O\nhit O\nthis O\nyear O\n's O\nhigh O\nof O\n114.92 O\nyen O\npushed O\nthe O\ncurrency O\ndown O\nsharply O\n. O\n\nHe O\nhad O\nsaid O\nthen O\nthat O\nthe O\nmarket O\n's O\nview O\non O\nJapan B-LOC\n's O\neconomy O\nwas O\ntoo O\npessimistic O\nand O\nthat O\nhe O\nbelieved O\nit O\nwas O\nstronger O\nthan O\nthe O\nmarket O\nthought O\n. O\n\nDealers O\nhave O\ncome O\nto O\nrefer O\nto O\n115 O\nyen O\nas O\nthe O\n\" O\nSakakibara B-PER\nceiling O\n\" O\nfor O\nthe O\ndollar O\nfollowing O\nthe O\nremark O\n. O\n\nAdding O\nto O\nthe O\ncomments O\nby O\n\" O\nMr B-PER\nYen I-PER\n\" O\n, O\nas O\nSakakibara B-PER\nis O\nknown O\nfor O\nhis O\nprominence O\nin O\nthe O\ncurrency O\nmarket O\n, O\nwas O\nBOJ B-ORG\ngovernor O\nMatsushita B-PER\n's O\nremark O\n. O\n\n\" O\nThe O\nrecent O\nlevel O\nof O\nthe O\nyen O\nexchange O\nrate O\nhas O\nbeen O\nstable O\n, O\nand O\nit O\ndoes O\nnot O\nappear O\nto O\nbe O\nmoving O\ntowards O\na O\nfurther O\ndepreciation O\nof O\nthe O\nyen O\nimmediately O\n, O\nso O\nimport O\nprices O\nare O\nlikely O\nto O\nstabilise O\nat O\ncurrent O\nlevels O\n, O\n\" O\nMatsushita B-PER\nsaid O\nin O\nan O\ninterview O\nwith O\nthe O\nNihon B-ORG\nKeizai I-ORG\nShimbun I-ORG\n. O\n\n\" O\nThe O\nfact O\nthat O\nhe O\ntouched O\non O\nthe O\nissue O\nof O\ninflation O\ntriggered O\nby O\nimport O\nprices O\nshows O\nthat O\nthe O\nBOJ B-ORG\ndoes O\nnot O\nwant O\na O\nfurther O\ndepreciation O\nof O\nthe O\nyen O\n, O\npast O\n115 O\nyen O\n, O\n\" O\nsaid O\nYasuhito B-PER\nKawashima I-PER\n, O\nchief O\nforex O\nmanager O\nat O\nToyo B-ORG\nTrust I-ORG\n& I-ORG\nBanking I-ORG\nCo I-ORG\n. O\n\nSome O\nsaid O\nthe O\ncentral O\nbank O\nmay O\nhave O\nbeen O\nconcerned O\na O\nweaker O\nyen O\nwould O\nlead O\nto O\nunfounded O\npessimism O\nabout O\nJapan B-LOC\n's O\neconomy O\n. O\n\n\" O\nThere O\nwas O\nconcern O\nthat O\nforeign O\ninvestors O\nmay O\nsell O\nJapanese B-MISC\nstocks O\nif O\nthe O\ndollar O\ngoes O\nabove O\n115 O\nyen O\n. O\n\nThe O\nBOJ B-ORG\ndoes O\nnot O\nwant O\nthe O\nyen O\n's O\nweakness O\nto O\nlead O\nto O\npessimism O\nover O\nthe O\neconomy O\n, O\n\" O\nsaid O\nTaisuke B-PER\nTanaka I-PER\n, O\nmarket O\nstrategist O\nwith O\nCredit B-ORG\nSuisse I-ORG\nin O\nTokyo B-LOC\n. O\n\nSenior O\nBOJ B-ORG\nofficials O\nhave O\nseparately O\nsaid O\nfinancial O\nmarkets O\n' O\nviews O\non O\nthe O\neconomy O\nhave O\nbeen O\ntoo O\nnegative O\n. O\n\n\" O\nI O\nrealise O\nthere O\nare O\nnegative O\nviews O\nin O\nthe O\nmarkets O\nabout O\nthe O\nimpact O\nof O\nthe O\nconsumption O\ntax O\nhike O\nand O\ndrop O\nin O\npublic O\nspending O\n, O\nbut O\nthe O\nmarkets O\nappear O\nto O\nbe O\nexaggerating O\nthe O\nmagnitude O\nof O\nthe O\nnegative O\nimpact O\n, O\n\" O\na O\nsenior O\nBOJ B-ORG\nofficial O\ntold O\nReuters B-ORG\non O\nFriday O\n. O\n\nThe O\nconsumption O\ntax O\nis O\ndue O\nto O\nraised O\nin O\nApril O\nfrom O\nthree O\nto O\nfive O\npercent O\n. O\n\n-DOCSTART- O\n\nLebanon B-LOC\nsentences O\npro-Israeli B-MISC\nwarlord O\nto O\ndeath O\n. O\n\nHaitham B-ORG\nHaddadin I-ORG\n\nBEIRUT B-LOC\n1996-12-06 O\n\nA O\nLebanese B-MISC\nmilitary O\ncourt O\non O\nFriday O\nsentenced O\nto O\ndeath O\nin O\nabsentia O\nthe O\ncommander O\nof O\nIsrael B-LOC\n's O\nsurrogate O\nmilitia O\nin O\nsouth O\nLebanon B-LOC\non O\ntreason O\ncharges O\n. O\n\nThe O\ncourt O\nconvicted O\nGeneral O\nAntoine B-PER\nLahd I-PER\n, O\nhead O\nof O\nthe O\nSouth B-ORG\nLebanon I-ORG\nArmy I-ORG\n( O\nSLA B-ORG\n) O\n, O\nof O\ncollaborating O\nwith O\nIsrael B-LOC\nwith O\nwhich O\nLebanon B-LOC\nis O\nofficially O\nat O\nwar O\n. O\n\nLahd B-PER\n, O\na O\n69-year-old O\nformer O\nLebanese B-MISC\narmy O\nmajor-general O\n, O\nheads O\nthe O\n3,000-strong O\nSLA B-ORG\nmilitia O\nwhich O\nhelps O\nIsrael B-LOC\nhold O\na O\nborder O\nzone O\nin O\nsouth O\nLebanon B-LOC\nto O\nward O\noff O\ncross-frontier O\nguerrilla O\nraids O\non O\nnorthern O\nIsrael B-LOC\n. O\n\nLahd B-PER\nsaid O\na O\nfew O\ndays O\nafter O\nthe O\ntrial O\nbegan O\non O\nFebruary O\n16 O\nthat O\nLebanese B-MISC\nauthorities O\nmust O\ndrop O\nthe O\ncharges O\nor O\nrisk O\nblocking O\nany O\npeace O\ndeal O\nwith O\nthe O\nJewish B-MISC\nstate O\n. O\n\nHe O\nsaid O\nIsrael B-LOC\nwas O\ncapable O\nof O\npressuring O\nLebanon B-LOC\n's O\nSyrian-backed B-MISC\ngovernment O\nto O\nstop O\nthe O\nlegal O\npursuit O\n. O\n\nThe O\ncharges O\nagainst O\nLahd B-PER\nwere O\n: O\nforming O\na O\nhostile O\narmy O\n, O\ncarrying O\nweapons O\non O\nIsrael B-LOC\n's O\nside O\n, O\nhelping O\nIsrael B-LOC\nstrip O\noff O\na O\npart O\nof O\nLebanese B-MISC\nterritory O\nby O\nviolence O\n, O\nforming O\nan O\narmed O\ngang O\n, O\nkilling O\nor O\ntrying O\nto O\nkill O\nLebanese B-MISC\ncivilians O\nby O\nartillery O\nshelling O\nand O\nkidnapping O\nLebanese B-MISC\ncitizens O\nfor O\nlong O\nperiods O\n. O\n\nShortly O\nbefore O\nLahd B-PER\n's O\ntrial O\nbegan O\n, O\na O\nBeirut B-LOC\nmilitary O\nprosecutor O\ncharged O\nanother O\n89 O\nformer O\nLebanese B-MISC\narmy O\nsoldiers O\nwith O\ncollaborating O\nwith O\nIsrael B-LOC\n. O\n\nNo O\ndate O\nhas O\nbeen O\nset O\nfor O\nthe O\ntrial O\nof O\nthe O\nmen O\n, O\nall O\nmembers O\nof O\nthe O\nSLA B-ORG\nliving O\nin O\nthe O\nIsraeli-held B-MISC\nzone O\nin O\nsouth O\nLebanon B-LOC\n. O\n\nIsrael B-LOC\nand O\nLahd B-PER\nhave O\nrepeatedly O\ndemanded O\nsafety O\nguarantees O\nfor O\nthe O\nSLA B-ORG\n-- O\na O\nmixed O\nChristian-Shi'ite B-MISC\nMoslem B-MISC\nforce O\n-- O\nwhich O\nthe O\nJewish B-MISC\nstates O\nregards O\nas O\nloyal O\nallies O\n. O\n\nIsrael B-LOC\nhas O\nsaid O\nthe O\nLebanese B-MISC\narmy O\nmust O\nincorporate O\nthe O\nSLA B-ORG\nfighters O\ninto O\nits O\nranks O\nas O\nan O\narmy O\nbrigade O\nas O\na O\ncondition O\nfor O\npeace O\n. O\n\nBut O\nLebanese B-MISC\npolitical O\nanalysts O\nhave O\nsaid O\nthat O\nwould O\nbe O\nout O\nof O\nthe O\nquestion O\nand O\nLebanese B-MISC\nauthorities O\npre-empted O\nthe O\nissue O\nby O\ntaking O\nlegal O\naction O\nagainst O\nLahd B-PER\n. O\n\nFormer O\nIsraeli B-MISC\nPrime O\nMinister O\nShimon B-PER\nPeres I-PER\n, O\ncalling O\nLahd B-PER\n\" O\na O\ngreat O\nLebanese B-MISC\npatriot O\n\" O\n, O\nsaid O\nearlier O\nthis O\nyear O\nLebanon B-LOC\nhad O\ninsulted O\nthe O\nSLA B-ORG\ncommander O\nby O\nordering O\nhis O\narrest O\non O\nthe O\ntreason O\ncharges O\n. O\n\nPeres B-PER\n, O\nwho O\nwas O\nousted O\nin O\nMay O\nby O\nrightwing O\nIsraeli B-MISC\nleader O\nBenjamin B-PER\nNetanyahu I-PER\n, O\nsaid O\nthere O\ncould O\nnot O\nbe O\nreal O\nnegotiations O\nwith O\nLebanon B-LOC\n\" O\nunless O\nit O\nwill O\nstop O\nthe O\nmaltreatment O\nof O\nthe O\nSLA B-ORG\nand O\nits O\ncommanders O\n. O\n\" O\n\nThe O\nBeirut B-LOC\nmilitary O\ncourt O\nalso O\nsentenced O\nto O\nlife O\nin O\njail O\nin O\nabsentia O\nEtian B-PER\nSaqr I-PER\n, O\nformer O\nhead O\nof O\nthe O\npro-Israeli B-MISC\nGuardians B-ORG\nof I-ORG\nthe I-ORG\nCedars I-ORG\n, O\na O\nsmall O\nrightwing O\nChristian B-MISC\ncivil O\nwar O\nmilitia O\n. O\n\nSaqr B-PER\n, O\nwhose O\ntrial O\nwas O\nconcurrent O\nwith O\nLahd B-PER\n's O\n, O\nwas O\nconvicted O\nof O\n\" O\ncontacting O\nthe O\nIsraeli B-MISC\nenemy O\n, O\npassing O\ninformation O\nto O\nIsrael B-LOC\nand O\nundertaking O\nhostile O\nacts O\nagainst O\nLebanon B-LOC\n\" O\n. O\n\n-DOCSTART- O\n\nTexas B-LOC\n/ O\nw O\nOkla B-LOC\nfed O\ncattle O\nmarket O\nthin O\nat O\n$ O\n67 O\n- O\nUSDA B-ORG\n. O\n\nAMARILLO B-LOC\n1996-12-06 O\n\nTrade O\nwas O\nslow O\nin O\nthe O\nPanhandle B-LOC\narea O\nFriday O\n, O\nUSDA B-ORG\nsaid O\n. O\n\nSlaughter O\nsteers O\nand O\nheifers O\nwere O\n$ O\n1.00 O\nper O\ncwt O\nlower O\n. O\n\nFeedlots O\nreporting O\nmoderate O\ninquiry O\n. O\n\nSales O\nreported O\non O\n8,200 O\nhead O\nslaughter O\nsteers O\nand O\n1,000 O\nheifers O\n; O\nfollowing O\nweekly O\nmovement O\nof O\n71,200 O\nhead O\n. O\n\nNote O\n- O\nall O\ncattle O\nprices O\nbased O\non O\nnet O\nweights O\nFOB O\nthe O\nfeedlot O\nafter O\na O\n4 O\npercent O\nshrink O\n. O\n\nSlaughter O\nSteers O\n- O\nSelect O\nand O\nChoice O\n2-3 O\n1150-1200 O\nlbs O\n67.00 O\n. O\n\nSlaughter O\nHeifers O\n- O\nSelect O\nand O\nChoice O\n2-3 O\n1050-1100 O\nlbs O\n67.00 O\n. O\n\nConfirmed O\n- O\n9,300 O\nWeek O\nAgo O\n- O\nNone O\nYear O\nAgo O\n- O\nNone O\n\n( O\n( O\nChicago B-LOC\nnewsdesk O\n312 O\n408 O\n8720 O\n) O\n) O\n\n-DOCSTART- O\n\nUSDA B-ORG\ndaily O\ncattle O\nand O\nhog O\nslaughter O\n- O\nDec O\n6 O\n. O\n\nEst O\ndaily O\nlivestock O\nslaughter O\nunder O\nFed B-ORG\ninspection O\n- O\nUSDA B-ORG\n\nCATTLE O\nCALVES O\nHOGS O\n\nFriday O\n12/06/96 O\n( O\nest O\n) O\n132,000 O\n7,000 O\n359,000 O\n\nWeek O\nago O\n( O\nest O\n) O\n130,000 O\n6,000 O\n346,000 O\n\nYear O\nago O\n( O\nact O\n) O\n132,000 O\n6,000 O\n336,000 O\n\nSaturday O\n12/07/96 O\n( O\nest O\n) O\n38,000 O\n0 O\n18,000 O\n\nWeek O\nto O\ndate O\n( O\nest O\n) O\n688,000 O\n31,000 O\n1,810,000 O\n\nSame O\nPeriod O\nLast O\nWeek O\n( O\nest O\n) O\n601,000 O\n26,000 O\n1,547,000 O\n\nSame O\nPeriod O\nLast O\nYear* O\n( O\nact O\n) O\n685,000 O\n31,000 O\n1,914,000 O\n\n1996 O\nYear O\nto O\ndate O\n33,549,000 O\n1,589,000 O\n84,894,000 O\n\n1995 O\nYear O\nto O\ndate* O\n32,970,000 O\n1,305,000 O\n88,800,000 O\n\nPercent O\nchange O\n1.8 O\n% O\n21.8 O\n% O\n- O\n4.4 O\n% O\n\n*1995 O\ntotals O\nadjusted O\nto O\nreflect O\nNASS B-ORG\nrevisions O\n1996 O\nTotals O\nare O\nsubject O\nto O\nrevision O\nYearly O\ntotals O\nmay O\nnot O\nadd O\ndue O\nto O\nrounding O\n. O\n\nPrevious O\nday O\nestimated O\nSteer O\nand O\nHeifer O\nCow O\nand O\nBull O\n\nThursday O\n100,000 O\n33,000 O\n\n-DOCSTART- O\n\nBALANCE O\n- O\nHartford B-LOC\n, O\nConn B-LOC\n. O\n\n, O\n$ O\n11 O\nmln O\n. O\n\nCITY O\nOF O\nHARTFORD B-LOC\n, O\nCONNECTICUT B-LOC\n\nRE O\n: O\n$ O\n25,000,000 O\n\nGENERAL O\nOBLIGATION O\nBONDS O\n\nMOODY B-ORG\n'S I-ORG\n: O\nAaa O\n/ O\nA1 O\nS&P B-ORG\n: O\nAAA O\n/ O\nAA- O\n\nDelivery O\nDate O\n: O\n12/16/1996 O\n\nFSA B-ORG\nINSURED O\n\nMaturity O\nBalance O\nCoupon O\nList O\n\n12/15/2000 O\n1,250M O\n6.25 O\n4.10 O\n\n12/15/2001 O\n575M O\n4.60 O\n4.20 O\n\n12/15/2003 O\n265M O\n4.40 O\n4.40 O\n\n12/15/2004 O\n625M O\n4.50 O\n4.50 O\n\n12/15/2005 O\n55M O\n4.60 O\n4.60 O\n\n12/15/2006 O\n145M O\n4.70 O\n4.70 O\n\n12/15/2007 O\n850M O\n4.85 O\n4.85 O\n\n12/15/2008 O\n1,200M O\n4.95 O\n4.95 O\n\n12/15/2009 O\n1,240M O\n5.05 O\n5.05 O\n\n12/15/2010 O\n1,250M O\n5.15 O\n5.15 O\n\n12/15/2011 O\n1,240M O\n5.25 O\n5.25 O\n\n12/15/2012 O\n1,200M O\n5.25 O\n5.30 O\n\n12/15/2013 O\n1,135M O\n5.30 O\n5.35 O\n\n12/15/2014 O\n850M O\n5.30 O\n5.35 O\n\nTotal O\n: O\n11,880M O\n\nState B-ORG\nStreet I-ORG\nBank I-ORG\nand I-ORG\nTrust I-ORG\nCompany I-ORG\n\nPrudential B-ORG\nSecurities I-ORG\nIncorporated I-ORG\n\nPaineWebber B-ORG\nIncorporated I-ORG\n\nFirst B-ORG\nUnion I-ORG\nCapital I-ORG\nMarkets I-ORG\nCorp. I-ORG\n- O\nNJ B-LOC\n\n-- O\nU.S. B-ORG\nMunicipal I-ORG\nDesk I-ORG\n, O\n212-859-1650 O\n\n-DOCSTART- O\n\n14 O\nyears O\nlater O\n, O\nFlorida B-LOC\nman O\ndies O\nfor O\nkilling O\n. O\n\nTALLAHASSEE B-LOC\n, O\nFla. B-LOC\n1996-12-06 O\n\nFourteen O\nyears O\nafter O\nhe O\nbludgeoned O\nand O\nshot O\na O\nman O\nwhose O\ntrailer O\nhome O\nhe O\nrobbed O\nin O\n1982 O\n, O\nJohn B-PER\nMills I-PER\nJr O\n. O\n\n, O\n41 O\n, O\nwas O\nput O\nto O\ndeath O\nin O\nFlorida B-LOC\n's O\nelectric O\nchair O\nFriday O\n. O\n\nAs O\nGlenn B-PER\nLawhon I-PER\n, O\na O\nrural O\nFlorida B-LOC\nminister O\nwho O\nis O\nthe O\nvictim O\n's O\nfather O\n, O\nlooked O\non O\n, O\nMills B-PER\nwas O\npronounced O\ndead O\nat O\n7:13 O\na.m. O\nEST O\n( O\n1213 O\nGMT B-MISC\n) O\nfor O\nthe O\nmurder O\nof O\nLester B-PER\nLawhon I-PER\n. O\n\nSpeaking O\nin O\nArabic B-MISC\n, O\nMills B-PER\nmade O\na O\nfinal O\nstatement O\nbefore O\nan O\nanonymous O\ncitizen O\nflipped O\nthe O\nswitch O\nthat O\nsent O\n2000 O\nvolts O\nof O\nelectricity O\nthrough O\nhis O\nbody O\n, O\nsaid O\nDepartment B-ORG\nof I-ORG\nCorrections I-ORG\nspokesman O\nEugene B-PER\nMorris I-PER\n, O\nwho O\nwas O\npresent O\nat O\nthe O\nexecution O\n. O\n\n\" O\nI O\nbear O\nwitness O\nthat O\nthere O\nis O\nno O\nGod B-PER\nbut O\nAllah B-PER\nand O\nI O\nbear O\nwitness O\nthat O\nthe O\nprophet O\nMohammed B-PER\nis O\nthe O\nmessenger O\nof O\nGod B-PER\n, O\n\" O\nhe O\nquoted O\nMills B-PER\nas O\nsaying O\n. O\n\nPrison O\nofficials O\nsaid O\nthey O\nhad O\nno O\nrecord O\nof O\nMills B-PER\n' O\nofficial O\nconversion O\n, O\nbut O\nthey O\nsaid O\nthat O\n, O\non O\nMay O\n14 O\n, O\n1991 O\n, O\nhe O\nhad O\nasked O\nthat O\na O\nnew O\nname O\n, O\nYuhanna B-PER\nAbdullah I-PER\nMuhammed I-PER\n, O\nbe O\nadded O\nto O\nhis O\nprison O\nfile O\n, O\nwhich O\nis O\nusually O\nan O\nindication O\nof O\na O\nconversion O\nto O\nIslam B-MISC\n. O\n\nMills B-PER\nis O\nthe O\n38th O\nperson O\nto O\ndie O\nin O\nFlorida B-LOC\n's O\nelectric O\nchair O\nsince O\nthe O\nU.S. B-ORG\nSupreme I-ORG\nCourt I-ORG\nreversed O\nitself O\nin O\n1976 O\nand O\nlegalised O\nthe O\ndeath O\npenalty O\n. O\n\nPrison O\nofficials O\nsaid O\nMills B-PER\nmade O\nno O\nspecial O\nrequest O\nfor O\na O\nlast O\nmeal O\nand O\ndid O\nnot O\neat O\nthe O\nsteak O\n, O\nfried O\npotatoes O\nand O\norange O\njuice O\noffered O\nhim O\n. O\n\nHe O\nspent O\nThursday O\nwith O\nfamily O\nmembers O\nand O\nhis O\nspiritual O\nadviser O\n, O\nMorris B-PER\nsaid O\n. O\n\nMills B-PER\nwas O\nscheduled O\nto O\ndie O\nWednesday O\nbut O\nhad O\nhis O\nsentence O\ntemporarily O\npostponed O\nby O\nthe O\nFlorida B-ORG\nSupreme I-ORG\nCourt I-ORG\n. O\n\nOn O\nThursday O\n, O\nthe O\n11th O\nCircuit O\nU.S. B-ORG\nCourt I-ORG\nof I-ORG\nAppeals I-ORG\nin O\nAtlanta B-LOC\ndenied O\nhis O\nappeal O\nin O\nfederal O\ncourt O\n. O\n\nIn O\nMarch O\n1982 O\n, O\nMills B-PER\nand O\naccomplice O\nMichael B-PER\nFrederick I-PER\nknocked O\non O\nthe O\ndoor O\nof O\nLester B-PER\nLawhon I-PER\n's O\ntrailer O\nin O\nan O\nattempt O\nto O\nrob O\nit O\n, O\npolice O\nsaid O\n. O\n\nLester B-PER\nLawhon I-PER\nwas O\ntaken O\nto O\na O\nnearby O\nairstrip O\nwhere O\nhe O\nwas O\nbludgeoned O\nwith O\na O\ntire O\niron O\n. O\n\nMills B-PER\nthen O\nfired O\ntwo O\nshots O\nthat O\nkilled O\nLawhon B-PER\nas O\nthe O\nvictim O\ntried O\nto O\nrun O\naway O\n. O\n\nFrederick B-PER\nis O\nserving O\na O\n347-year O\nsentence O\n. O\n\n-DOCSTART- O\n\nNew B-LOC\nYork I-LOC\ngrain O\nfreight O\nfixtures O\n- O\nDec O\n5 O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nMana O\n50,000 O\ntonnes O\nsoybeans O\nUSG O\n/ O\nChina B-LOC\n10-15/12 O\n$ O\n23.50 O\n10,000 O\n/ O\n4,000 O\nGeePee O\n. O\n\n-- O\nNew B-ORG\nYork I-ORG\nCommodities I-ORG\nDesk I-ORG\n+1 O\n212 O\n859 O\n1640 O\n\n-DOCSTART- O\n\nIowa-S B-LOC\nMinn B-LOC\nfed O\ncattle O\nmarket O\nquiet O\n, O\nno O\nsales-USDA B-MISC\n. O\n\nDES B-LOC\nMOINES I-LOC\n1996-12-06 O\n\nSlaughter O\nsteers O\nand O\nheifers O\nnot O\ntested O\n, O\ncompared O\nwith O\nThursday O\n's O\nclose O\n, O\nUSDA B-ORG\nsaid O\n. O\n\nTrade O\nslow O\n. O\n\nDemand O\nand O\nseller O\ninterest O\nlight O\n. O\n\nOfferings O\nlight O\n. O\n\nSteers O\n- O\nSelect O\nand O\nChoice O\n2-4 O\nno O\nsales O\n. O\n\nHeifers O\n- O\nSelect O\nand O\nChoice O\n2-4 O\nno O\nsales O\n. O\n\nCarcass O\nBasis O\n( O\nweight O\nonly O\n) O\nCompared O\nThursdays O\nClose O\n- O\nSlaughter O\nsteers O\nand O\nheifers O\nnot O\ntested O\n. O\n\nSteers O\n- O\nSelect O\nand O\nChoice O\n2-4 O\nno O\nsales O\n. O\n\nHolstein O\n- O\n( O\nweight O\nonly O\n) O\nSelect O\nto O\nmostly O\nChoice O\n2-3 O\n1250-1400 O\nlbs O\nno O\nsales O\n. O\n\nHolsteins O\n- O\n( O\ngrade O\nand O\nweight O\n) O\nChoice O\n2-3 O\n1250-1450 O\nlbs O\nno O\nsales O\nSelect O\n2-3 O\n1250-1450 O\nlbs O\nno O\nsales O\n. O\n\nHeifers O\n- O\nSelect O\nand O\nChoice O\n2-4 O\nno O\nsales O\n. O\n\nConfirmed O\n- O\nNone O\nWeek O\nAgo O\n- O\n800 O\nYear O\nAgo O\n- O\n900 O\n\nWk O\nto O\nDate O\n- O\nNone O\nWeek O\nAgo O\n- O\n800 O\nYear O\nAgo O\n- O\n900 O\n\n( O\n( O\nChicago B-LOC\nnewsdesk O\n312-408-8720 O\n) O\n) O\n\n-DOCSTART- O\n\nMan O\nstole O\npigs O\n, O\ntipped O\nstrippers O\n, O\ngets O\n10 O\nyears O\n. O\n\nAPPLETON B-LOC\n, O\nWis B-LOC\n. O\n\n1996-12-06 O\n\nA O\nfarmhand O\nused O\nthe O\nproceeds O\nfrom O\nstolen O\npigs O\nto O\nlavish O\ntips O\non O\ndancers O\nat O\nstrip O\nclubs O\nand O\noffered O\none O\n$ O\n3,000 O\nto O\npay O\nfor O\nbreast O\nimplant O\nsurgery O\n, O\nauthorities O\nsaid O\nFriday O\n. O\n\nIn O\nsentencing O\nDarrel B-PER\nVoeks I-PER\n, O\n38 O\n, O\nto O\na O\n10-year O\nprison O\nterm O\non O\nThursday O\n, O\nOutagmie B-LOC\nCounty I-LOC\nCircuit O\nCourt O\nJudge O\nDennis B-PER\nLuebke I-PER\nsaid O\nhe O\nwas O\n\" O\na O\nthief O\nby O\nhabit O\n. O\n\" O\n\n\" O\nYou O\nare O\nself-indulgent O\n. O\n\nYou O\nare O\nnarcissitic O\n, O\n\" O\nLuebke O\nsaid O\nat O\nthe O\nsentencing O\n, O\nadding O\nVoeks B-PER\nshould O\npay O\nrestitution O\nof O\nmore O\nthan O\n$ O\n100,000 O\nto O\nthe O\nfarming O\nfamily O\nwho O\nhad O\nhired O\nhim O\n. O\n\nVoeks B-PER\n, O\nwho O\nwas O\nalready O\non O\nprobation O\nfor O\nprior O\npig O\nthefts O\n, O\npleaded O\nthat O\nhe O\nwas O\ntrying O\nto O\npay O\nbills O\nfor O\nhis O\nex-wife O\nand O\nchildren O\n. O\n\nBut O\nthe O\ncourt O\nheard O\nthat O\nreceipts O\nshowed O\nmuch O\nof O\nthe O\nmoney O\nwent O\nto O\ndancers O\nat O\nstrip O\nclubs O\nwhere O\nhe O\nwas O\nknown O\nas O\na O\nbig O\ntipper O\n. O\n\nOne O\nstripper O\nsaid O\nVoeks B-PER\noffered O\nto O\ngive O\nher O\n$ O\n3,000 O\nfor O\nbreast O\nimplant O\nsurgery O\n. O\n\n-DOCSTART- O\n\nCanadian B-MISC\ngrain O\nstatistics O\nweekly O\n. O\n\nCHICAGO B-LOC\n, O\nDec O\n6 O\n( O\nReuter B-ORG\n) O\nStatistics O\nfor O\nthe O\nweek O\nending O\nDecember O\n1 O\nin O\n000 O\n's O\ntonnes O\n. O\n\n- O\nCanadian B-ORG\nGrain I-ORG\nCommission I-ORG\n\nVisible O\nSupplies O\nFarmers O\nDeliveries O\n\nCurr O\nWk O\nYr O\nAgo O\nCurr O\nWk O\nYr O\nto O\nDate O\nYr O\nAgo O\n\nWheat O\n4320.2 O\n3909.3 O\n288.5 O\n6278.9 O\n5580.0 O\n\nDurum O\n1168.9 O\n1225.0 O\n44.3 O\n965.3 O\n1069.6 O\n\nOats O\n286.5 O\n284.6 O\n31.9 O\n937.3 O\n581.2 O\n\nBarley O\n1074.0 O\n1104.8 O\n178.0 O\n2531.4 O\n1897.1 O\n\nRye O\n44.6 O\n86.3 O\n2.3 O\n108.2 O\n119.2 O\n\nFlax O\n165.2 O\n181.9 O\n14.9 O\n231.4 O\n332.9 O\n\nCanola O\n646.6 O\n769.4 O\n60.5 O\n1902.0 O\n2147.6 O\n\nCorn O\n79.6 O\n163.5 O\n9.4 O\n95.7 O\n252.0 O\n\nTotal O\n7785.8 O\n7724.8 O\n629.8 O\n13050.2 O\n11979.6 O\n\nExports O\nDomestic O\nDisappearance O\n\nCurr O\nWk O\nYTD O\nYr O\nAgo O\nCurr O\nWk O\nYTD O\nYr O\nAgo O\n\nWheat O\n387.4 O\n4677.8 O\n4553.6 O\n55.2 O\n1039.7 O\n846.1 O\n\nDurum O\n129.0 O\n1515.9 O\n1220.6 O\n4.6 O\n75.8 O\n73.3 O\n\nOats O\n40.0 O\n561.0 O\n391.9 O\n4.8 O\n149.6 O\n115.0 O\n\nBarley O\n110.8 O\n1203.4 O\n506.0 O\n48.2 O\n941.0 O\n786.6 O\n\nRye O\n4.1 O\n60.7 O\n57.9 O\n3.0 O\n10.7 O\n18.9 O\n\nFlax O\n7.2 O\n154.1 O\n235.7 O\n1.1 O\n22.2 O\n15.7 O\n\nCanola O\n47.1 O\n988.1 O\n1135.5 O\n46.7 O\n894.9 O\n822.0 O\n\nCorn O\n4.4 O\n15.1 O\n87.0 O\n0.6 O\n22.1 O\n11.1 O\n\nTotal O\n730.0 O\n9176.1 O\n8188.2 O\n164.2 O\n3156.0 O\n2686.7 O\n\nIn O\naddition O\n, O\nStatistics B-ORG\nCanada I-ORG\nindicated O\nthe O\nfollowing O\nexports O\nto O\nthe O\nU.S. B-LOC\nbetween O\nAugust O\nand O\nSeptember O\n1996 O\n, O\nin O\ntonnes O\n: O\n\nOats O\nRye O\nFlaxseed O\nCanola O\nCorn O\n\nExports O\n29,200 O\n17,200 O\n7,700 O\n100 O\n59,400 O\n\nYear O\nAgo O\n47,000 O\n24,300 O\n8,700 O\n8,200 O\n12,200 O\n\n( O\nChicago B-LOC\nnewsdesk O\n312 O\n408 O\n8720 O\n) O\n\n-DOCSTART- O\n\nNYMEX B-ORG\nnatgas O\nends O\nsharply O\nlower O\non O\nweather O\noutlook O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nNYMEX B-ORG\nHenry B-LOC\nHub I-LOC\nnatgas O\nfutures O\nsettled O\nsignificantly O\nlower O\nFriday O\n, O\npressured O\nearly O\nby O\nprofit O\ntaking O\nand O\ndriven O\neven O\nlower O\nlate O\nby O\nthe O\nNational B-ORG\nWeather I-ORG\nService I-ORG\n's O\nbearish O\nsix O\nto O\n10 O\nday O\nforecast O\n, O\nsources O\nsaid O\n. O\n\nJanuary O\nended O\n29.7 O\ncents O\nlower O\nat O\n$ O\n3.487 O\nper O\nmillion O\nBritish B-MISC\nthermal O\nunits O\nafter O\ndipping O\nto O\na O\nlow O\nof O\n$ O\n3.46 O\n. O\n\nFeb O\nsettled O\ndown O\n22 O\ncents O\nat O\n$ O\n3.186 O\n. O\n\nMost O\nothers O\nalso O\nwere O\ndown O\n. O\n\n\" O\nWeather O\nforecasts O\nhave O\nbeen O\nsketchy O\n. O\n\nNow O\nthe O\nNational B-ORG\nWeather I-ORG\nService I-ORG\nis O\ncalling O\nfor O\nabove-normal O\ntemperatures O\nin O\nmore O\nthan O\nhalf O\nof O\nthe O\nU.S. B-LOC\n, O\n\" O\none O\nfutures O\ntrader O\nsaid O\n. O\n\nIn O\nits O\nforecast O\n, O\nthe O\nNWS B-ORG\nsaid O\nit O\nexpects O\nabove-normal O\ntemperatures O\n\" O\nover O\nthe O\nlower O\n48 O\nstates O\n\" O\nfrom O\nDecember O\n12 O\nthrough O\nDecember O\n16 O\n. O\n\nWith O\nmore O\nroom O\nto O\nthe O\ndownside O\nanticipated O\nearly O\nnext O\nweek O\n, O\ntraders O\nsaid O\nsupport O\nin O\nJanuary O\nwas O\nat O\n$ O\n3.47 O\n, O\nthen O\n$ O\n3.35 O\n. O\n\nThe O\nnext O\nbackstops O\nwere O\nseen O\nat O\n$ O\n3.11 O\nand O\n$ O\n3.04 O\n, O\nthe O\nlow O\nset O\non O\nNovember O\n21 O\n. O\n\nResistance O\nwas O\npegged O\nat O\nthe O\nnew O\ncontract O\nhigh O\nof O\n$ O\n3.80 O\n. O\n\nIn O\nthe O\ncash O\nmarket O\n, O\nGulf B-LOC\nCoast I-LOC\nprices O\nwere O\naround O\n$ O\n3.60 O\nshortly O\nbefore O\nnomination O\ndeadlines O\n. O\n\nMidcontinent O\nprices O\nwere O\nsimilarly O\nlower O\nin O\nthe O\n$ O\n3.40s. O\nNew B-LOC\nYork I-LOC\ncity O\ngate O\ngas O\nslipped O\ninto O\nthe O\n$ O\n4.40s O\n, O\ndown O\nalmost O\n15 O\ncents O\n. O\n\nNYMEX B-ORG\nsaid O\nan O\nestimated O\n35,662 O\nHub O\ncontracts O\ntraded O\n, O\ndown O\nfrom O\nThursday O\n's O\nrevised O\ntally O\nof O\n43,955 O\n. O\n\nNYMEX B-ORG\nAlberta B-LOC\nnatgas O\nremained O\nuntraded O\n, O\nwith O\nJanuary O\nsettling O\nat O\n$ O\n1.65 O\n, O\noff O\n10 O\ncents O\nfrom O\nThursday O\n. O\n\nPhysical O\nprices O\nfor O\nthe O\nweekend O\nat O\nthe O\nAECO B-ORG\nstorage O\nhub O\nwere O\nalso O\ndown O\nabout O\n10 O\ncents O\nin O\nthe O\nC$ B-MISC\n1.92-1.97 O\nper O\ngigajoule O\n, O\nor O\n$ O\n1.52-1.56 O\nper O\nmmBtu O\nrange O\n, O\npressured O\nby O\nunseasonably O\nmild O\nweather O\nin O\nwestern O\nCanada B-LOC\n. O\n\nNYMEX B-ORG\nPermian B-MISC\nnatgas O\n, O\nalso O\nuntraded O\n, O\nended O\n10 O\ncents O\nlower O\nat O\n$ O\n2.90 O\n. O\n\nIn O\ncongruence O\nwith O\nfutures O\n, O\nPermian B-MISC\ncash O\nprices O\nfor O\nthe O\nweekend O\nfell O\nmore O\nthan O\n10 O\ncents O\nto O\nthe O\nhigh O\n- O\n$ O\n3.40s. O\n\nOn O\nthe O\nKCBT B-ORG\n, O\nJanuary O\nfinished O\n26.5 O\ncents O\nlower O\nat O\n$ O\n3.35 O\nafter O\ndipping O\nto O\na O\nlow O\nof O\n$ O\n3.33 O\nearlier O\nin O\nthe O\nsession O\n. O\n\nFebruary O\nwas O\ndown O\n22 O\ncents O\nat O\nthe O\nclose O\n, O\nwhile O\nother O\ndeferreds O\nwere O\n4.5 O\nto O\nnine O\ncents O\nlower O\n. O\n\nThe O\nEast O\n/ O\nWest O\nspread O\nnarrowed O\nby O\n3.2 O\ncents O\nto O\n13.7 O\ncents O\n( O\nNYMEX B-ORG\npremium O\n) O\n. O\n\nPhysical O\nprices O\nat O\nWaha B-LOC\nfor O\nthe O\nweekend O\nlost O\nmore O\nthan O\n15 O\ncents O\nto O\nthe O\nlow-to-mid O\n$ O\n3.50s O\nas O\nmilder O\nweather O\nmoved O\ninto O\nthe O\nSouthwest O\n. O\n\n-- O\nH B-PER\nMcCulloch I-PER\n, O\nNew B-ORG\nYork I-ORG\nPower I-ORG\nDesk I-ORG\n+212-859-1628 O\n\n-DOCSTART- O\n\nU.S. B-LOC\nbarges O\nlightly O\nquoted O\non O\ncall O\nsession O\n. O\n\nST. B-LOC\nLOUIS I-LOC\n1996-12-06 O\n\nU.S. B-LOC\nbarge O\nrates O\nwere O\nlightly O\nquoted O\nFriday O\non O\nthe O\nSt. B-LOC\nLouis I-LOC\nMerchants O\nExchange O\ncall O\nsession O\n. O\n\nNo O\nbarges O\ntraded O\nversus O\nno O\ntrades O\nThursday O\n. O\n\n- O\nTwo O\nbarges O\nnext O\nweek O\nIllinois B-LOC\nbid O\nat O\na O\nsteady O\n130 O\npercent O\nof O\ntariff O\n, O\noffered O\nat O\n135 O\npercent O\n. O\n\n- O\nOne O\nbarge O\n, O\nweek O\nof O\nDecember O\n15 O\n, O\nlower O\nOhio B-LOC\nbid O\n2-1/2 O\npoints O\nhigher O\nat O\n105 O\npercent O\n, O\nno O\noffer O\n. O\n\nTwo O\nbarges O\n, O\nweek O\nof O\nJanuary O\n5 O\n, O\nIllinois B-LOC\n, O\noffered O\nfive O\npoints O\nlower O\nat O\n195 O\npercent O\n, O\nbid O\nat O\n150 O\npercent O\n. O\n\n- O\nFive O\nbarges O\n, O\n30-day O\nopen O\n, O\nmid-Mississippi B-MISC\n( O\nMcGregor B-PER\nand O\nsouth O\n) O\nbid O\nat O\n160 O\npercent O\n, O\noffered O\nat O\n170 O\npercent O\n, O\nno O\ncomparisons O\n. O\n\n- O\n36 O\nbarges O\n, O\ntwo O\neach O\nweek O\nMay-August O\n, O\nIllinois B-LOC\n, O\noffered O\nat O\n130 O\npercent O\nof O\ntariff O\n, O\nno O\nbid O\nor O\ncomparison O\n. O\n\n- O\n36 O\nbarges O\n, O\ntwo O\neach O\nweek O\nMay-August O\n, O\nmid-Mississippi B-MISC\noffered O\nat O\na O\nsteady O\n135 O\npercent O\n, O\nbid O\nat O\n120 O\npercent O\n( O\nbasis O\none O\neach O\nweek O\n) O\n. O\n\n-- O\nChicago B-LOC\nnewsdesk O\n312-408 O\n8720 O\n\n-DOCSTART- O\n\nCBOT B-ORG\ngrain O\n/ O\noilseed O\nreceipts O\nand O\nshipments O\n. O\n\nCHICAGO B-LOC\n1996-12-06 O\n\nGrain O\nand O\nsoybean O\nreceipts O\nand O\nshipments O\n, O\nin O\nbushels O\n, O\nat O\ndelivery O\nlocations O\nfor O\nthe O\nprevious O\ntrading O\nday O\n, O\naccording O\nto O\nthe O\nChicago B-ORG\nBoard I-ORG\nof I-ORG\nTrade I-ORG\n- O\n\nReceipts O\nShipments O\n\nWheat O\n\nChicago B-LOC\n0 O\n0 O\n\nSt. B-LOC\nLouis I-LOC\n21,346 O\n0 O\n\nToledo B-LOC\n61,514 O\n0 O\n\nCorn O\n\nChicago B-LOC\n78,056 O\n0 O\n\nSt. B-LOC\nLouis I-LOC\n217,092 O\n75,810 O\n\nToledo B-LOC\n285,505 O\n561,287 O\n\nOats O\n\nChicago B-LOC\n0 O\n0 O\n\nMinneapolis B-LOC\n306,364 O\n153,231 O\n\nSoybeans O\n\nChicago B-LOC\n8,674 O\n484,018 O\n\nSt. B-LOC\nLouis I-LOC\n253,821 O\n223,172 O\n\nToledo B-LOC\n64,334 O\n160,476 O\n\n( O\n( O\nChicago B-ORG\nNewsdesk I-ORG\n312-408-8720 O\n) O\n) O\n\n-DOCSTART- O\n\nClinton B-PER\nto O\nhave O\nmore O\nnews O\nconferences O\nin O\n2nd O\nterm O\n. O\n\nWASHINGTON B-LOC\n1996-12-06 O\n\nPresident O\nClinton B-PER\naims O\nto O\nhold O\nmore O\nnews O\nconferences O\nin O\nhis O\nsecond O\nterm O\nand O\nwill O\nhave O\none O\nDec. O\n13 O\n, O\nthe O\nWhite B-LOC\nHouse I-LOC\nsaid O\nFriday O\n. O\n\nThe O\npresident O\nhad O\nonly O\ntwo O\nformal O\n, O\nfull-blown O\nnews O\nconferences O\nlast O\nyear O\n, O\none O\nin O\nJanuary O\nand O\none O\nafter O\nhe O\nwon O\nre-election O\nin O\nNovember O\n, O\nalthough O\nhe O\nhad O\nvarious O\nother O\nlimited O\nsessions O\nwith O\nthe O\npress O\n. O\n\nWhite B-LOC\nHouse I-LOC\nspokesman O\nMike B-PER\nMcCurry I-PER\nsaid O\nClinton B-PER\n\" O\nplans O\nto O\nhave O\nregular O\nnews O\nconferences O\n\" O\nduring O\nhis O\nsecond O\nterm O\n. O\n\nBut O\nwhen O\nasked O\nhow O\nfrequent O\nthese O\nwould O\nbe O\n, O\nhe O\nwas O\nevasive O\n, O\nsaying O\n, O\n\" O\nperiodic O\n, O\noccasional O\n. O\n\" O\n\n\" O\nHe O\nenjoys O\nthe O\ngive O\nand O\ntake O\n\" O\nwith O\nreporters O\n, O\nthe O\nspokesman O\nadded O\n. O\n\n-DOCSTART- O\n\nAction O\nPerformance O\nto O\nacquire O\nfirms O\n. O\n\nTEMPE B-LOC\n, O\nAriz B-LOC\n. O\n\n1996-12-06 O\n\nAction B-ORG\nPerformance I-ORG\nCos I-ORG\nInc I-ORG\nsaid O\nFriday O\nit O\nhas O\nagreed O\nto O\nacquire O\nMotorsport B-ORG\nTraditions I-ORG\nLtd I-ORG\nand O\nCreative B-ORG\nMarketing I-ORG\n& I-ORG\nPromotions I-ORG\nInc I-ORG\nfor O\nabout O\n$ O\n13 O\nmillion O\nin O\ncash O\nand O\nstock O\n. O\n\nThe O\ntwo O\nfirms O\nto O\nbe O\nacquired O\nhave O\nabout O\n$ O\n25 O\nmillion O\nin O\nannual O\nrevenues O\nfrom O\nthe O\ndesign O\n, O\nmanufacture O\nand O\nsale O\nand O\ndistribution O\nof O\nlicensed O\nmotorsports O\nproducts O\n. O\n\nThe O\ndeal O\nis O\nexpected O\nto O\nclose O\nby O\nthe O\nend O\nof O\nthe O\nyear O\nsubject O\nto O\ndue O\ndiligence O\nand O\nother O\ncustomary O\nclosing O\nconditions O\n. O\n\n-DOCSTART- O\n\nHalf O\nof O\ndog O\nbites O\nprovoked O\n, O\nsays O\nAmerican B-MISC\nvet O\n. O\n\nCHICAGO B-LOC\n1996-12-06 O\n\nAs O\nmany O\nas O\n1 O\nmillion O\ndog O\nbites O\nare O\nrecorded O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\nevery O\nyear O\nand O\nhalf O\nof O\nthem O\nare O\nprovoked O\nby O\nhumans O\n, O\na O\nveterinarian O\ntold O\nfellow O\nanimal O\ndoctors O\non O\nFriday O\n. O\n\nThe O\nHumane O\nSociety O\nof O\nthe O\nUnited B-LOC\nStates I-LOC\nestimates O\nthat O\nbetween O\n500,000 O\nand O\none O\nmillion O\nbites O\nare O\ndelivered O\nby O\ndogs O\neach O\nyear O\n, O\nmore O\nthan O\nhalf O\nof O\nwhich O\nare O\nsuffered O\nby O\nchildren O\n. O\n\n\" O\nMost O\nbites O\ncan O\nbe O\nprevented O\nby O\nteaching O\nchildren O\nhow O\nto O\nrespect O\na O\ndog O\n, O\n\" O\nMichael B-PER\nCornwell I-PER\nof O\nthe O\nGlencoe B-ORG\nAnimal I-ORG\nHospital I-ORG\nin O\nColumbus B-LOC\n, O\nOhio B-LOC\n, O\ntold O\nthe O\nannual O\nmeeting O\nof O\nthe O\nAmerican B-ORG\nVeterinary I-ORG\nMedical I-ORG\nAssociation I-ORG\n. O\n\n\" O\nLet O\n's O\nnot O\nlet O\nour O\nkids O\njump O\non O\nthem O\nor O\ncrawl O\non O\nthem O\n. O\n\nDogs O\nand O\nchildren O\ndo O\nn't O\nhave O\nto O\nhave O\nan O\ninteraction O\n. O\n\nLet O\n's O\nrespect O\ntheir O\nterritories O\n, O\n\" O\nhe O\nsaid O\n. O\n\nCornwell B-PER\nsaid O\n50 O\npercent O\nof O\nreported O\nbites O\nwere O\nprovoked O\nby O\na O\nperson O\nand O\n60 O\npercent O\nwere O\nsuffered O\nby O\nchildren O\n. O\n\nHe O\nalso O\nestimated O\nthat O\nonly O\n25 O\npercent O\nof O\nbites O\nwere O\nreported O\nbecause O\nmedical O\nattention O\nwas O\nnot O\nneeded O\n. O\n\nDon B-PER\nRieck I-PER\n, O\npresident O\nof O\nthe O\nNational B-ORG\nAnimal I-ORG\nControl I-ORG\nAssociation I-ORG\n, O\nsaid O\naggressiveness O\nin O\ndogs O\nwas O\nrelated O\nmore O\nto O\ngender O\nthan O\nbreed O\nand O\na O\nmale O\ndog O\nthat O\nhad O\nnot O\nbeen O\nneutered O\nwas O\nthree O\ntimes O\nmore O\nlikely O\nto O\nbite O\nthan O\nan O\nunspayed O\nfemale O\n. O\n\nThe O\nfive O\nbreeds O\ncredited O\nwith O\nthe O\nmost O\nincidents O\nwere O\nchow O\nchows O\n, O\nRottweilers B-MISC\n, O\nGerman B-MISC\nshepherds I-MISC\n, O\ncocker B-MISC\nspaniels I-MISC\nand O\nDalmatians B-MISC\n. O\n\" O\n\nThe O\ntrends O\nin O\ndog O\nbites O\nby O\nparticular O\nbreeds O\nhave O\nmore O\nto O\ndo O\nwith O\nfad O\npets O\nowned O\nby O\nindividuals O\nwho O\nneed O\nto O\nhave O\nsomething O\nunique O\n. O\n\nSpeaking O\nstrictly O\nof O\ndogs O\n, O\n15 O\nyears O\nago O\nthe O\nmacho O\nfad O\npet O\nwas O\na O\nDoberman B-MISC\n. O\n\nToday O\n, O\nRottweilers B-MISC\nare O\non O\nthe O\nway O\nup O\n, O\n\" O\nRieck B-PER\nsaid O\n. O\n\nIf O\napproached O\nby O\na O\nstray O\ndog O\n, O\nchildren O\nshould O\nbe O\ntaught O\nto O\nstand O\nstill O\nwith O\nfists O\nfolded O\nunderneath O\nthe O\nneck O\n, O\nelbows O\nin O\n, O\nand O\ngaze O\nforward O\nuntil O\nthe O\ndog O\ngoes O\naway O\n. O\n\n-DOCSTART- O\n\nIowa-S B-LOC\nMinn B-LOC\nfeedlot O\ncattle O\nmarket O\nnot O\ntested- O\nUSDA B-ORG\n. O\n\nDES B-LOC\nMOINES I-LOC\n1996-12-06 O\n\nSteers O\nand O\nheifers O\nwere O\nnot O\ntested O\n, O\ncompared O\nwith O\nThursday O\n's O\nclose O\n, O\nUSDA B-ORG\nsaid O\n. O\n\nReported O\nsales O\nfor O\nFri- O\nNone O\n. O\n\nWeek O\nto O\nDate O\n- O\nNone O\n. O\n\n( O\n( O\nChicago B-LOC\nnewsdesk O\n312-408-8720 O\n) O\n) O\n\n-DOCSTART- O\n\nNebraska B-LOC\nfed O\ncattle O\nroundup O\n- O\nUSDA B-ORG\n. O\n\nOMAHA B-LOC\n1996-12-06 O\n\nSlaughter O\nsteers O\nand O\nheifers O\nwere O\nnot O\nestablished O\nThursday O\n. O\n\nDemand O\nlimited O\n. O\n\nSeller O\ninterest O\nlight O\n. O\n\n- O\nUSDA B-ORG\n\nThursday O\n200 O\nLast O\nWeek O\nHoliday O\nLast O\nYear O\nN O\n/ O\nA O\n\nWeek O\nto O\nDate O\n3,500 O\nSm O\nPd O\nLst O\nWk O\n800 O\nSm O\nPd O\nLst O\nYr O\nN O\n/ O\nA O\n\nDressed O\nBasis O\nDelivered O\nnot O\nwell O\ntested O\n. O\n\nDressed O\nBasis O\nSteers O\n: O\nFew O\nSelect O\nand O\nChoice O\n2-3 O\n, O\n1200-1300 O\nlbs O\n112.00 O\n; O\nload O\nearly O\n114.00 O\n. O\n\nDressed O\nBasis O\nHeifers O\n: O\nFew O\nSelect O\nand O\nChoice O\n2-3 O\n, O\n1100-1200 O\nlbs O\n112.00 O\n. O\n\n-DOCSTART- O\n\nFour O\nAfricans B-MISC\nsaid O\nto O\nvie O\nfor O\ntop O\nU.N. B-ORG\npost O\n. O\n\nEvelyn B-PER\nLeopold I-PER\n\nUNITED B-ORG\nNATIONS I-ORG\n1996-12-06 O\n\nFour O\nAfrican B-MISC\nstates O\nare O\nready O\nto O\nnominate O\ncandidates O\nfor O\nthe O\npost O\nof O\nU.N. B-ORG\nsecretary-general O\non O\nFriday O\nnow O\nthat O\nBoutros B-PER\nBoutros-Ghali I-PER\nhas O\ntemporarily O\nput O\naside O\nhis O\nbid O\nfor O\nre-election O\n. O\n\nThe O\nnominees O\n, O\naccording O\nto O\ndiplomats O\n, O\nare O\n: O\nKofi B-PER\nAnnan I-PER\nof O\nGhana B-LOC\n, O\nthe O\nU.N. B-ORG\nundersecretary-general O\nfor O\npeacekeeping O\n; O\nAhmedou B-PER\nOuld I-PER\nAbdallah I-PER\nof O\nMauritania B-LOC\n, O\nthe O\nformer O\nU.N. B-ORG\nspecial O\nenvoy O\nfor O\nBurundi B-LOC\n; O\nAmara B-PER\nEssy I-PER\nof O\nthe O\nIvory B-LOC\nCoast I-LOC\n, O\nits O\nforeign O\nminister O\nand O\nthe O\nU.N. B-ORG\nGeneral I-ORG\nAssembly I-ORG\npresident O\nin O\n1994-95 O\n; O\nand O\nHamid B-PER\nAlgabid I-PER\nof O\nNiger B-LOC\n, O\nthe O\nsecretary-general O\nof O\nthe O\nOrganisation B-ORG\nof I-ORG\nthe I-ORG\nIslamic I-ORG\nConference I-ORG\n. O\n\nRepresentatives O\nof O\nthe O\nU.N. B-ORG\nmissions O\nof O\nGhana B-LOC\n, O\nthe O\nIvory B-LOC\nCoast I-LOC\n, O\nMauritania B-LOC\nand O\nNiger B-LOC\nhave O\nscheduled O\na O\nmeeting O\nwith O\nSecurity B-ORG\nCouncil I-ORG\npresident O\nPaolo B-PER\nFulci I-PER\nof O\nItaly B-LOC\nto O\nhand O\nin O\nthe O\nnominations O\nin O\nwriting O\n, O\nthe O\nenvoys O\nsaid O\n. O\n\nIt O\nwas O\nnot O\nknown O\nif O\nother O\ncandidates O\nwould O\nstep O\nforward O\n. O\n\nDiplomats O\nsaid O\nGeneral O\nJoseph B-PER\nGarba I-PER\nof O\nNigeria B-LOC\n, O\na O\nU.N. B-ORG\nGeneral I-ORG\nAssembly I-ORG\npresident O\nin O\n1989-90 O\n, O\nwas O\nputting O\nforth O\nhis O\nown O\ncandidacy O\nwithout O\nbeing O\nnominated O\nby O\nhis O\ncountry O\n. O\n\nBoutros-Ghali B-PER\non O\nWednesday O\nopened O\nthe O\ndoor O\nfor O\nother O\nAfricans B-MISC\nto O\ncontest O\nhis O\njob O\nby O\nsaying O\nhe O\nwas O\nsuspending O\ntemporarily O\nhis O\ncandidacy O\nbut O\nwas O\nnot O\nwithdrawing O\ncompletely O\nfrom O\nthe O\nrace O\n. O\n\nHis O\nsupporters O\nsaid O\nthis O\nmeant O\nhe O\nremained O\na O\ncandidate O\nin O\ncase O\nthe O\nrace O\nreached O\nan O\nimpasse O\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\non O\nNov. O\n19 O\nvetoed O\nhis O\nbid O\nfor O\nre-election O\nwhile O\nthe O\nother O\n14 O\nSecurity B-ORG\nCouncil I-ORG\nmembers O\nsupported O\nhim O\n. O\n\nThe O\nmove O\nby O\nthe O\nAfrican B-MISC\nstates O\nmeans O\nthat O\nthe O\ncouncil O\ncould O\nbegin O\nvoting O\non O\ncandidates O\nnext O\nweek O\n, O\na O\nprocedure O\nthat O\ncould O\neither O\nresult O\nin O\na O\ndecision O\nor O\nturn O\ninto O\na O\nbitter O\nfight O\nwith O\nvetoes O\nagainst O\neach O\nnominee O\n. O\n\nThe O\nSecurity B-ORG\nCouncil I-ORG\nhas O\nto O\nvote O\non O\na O\nnew O\nsecretary-general O\nand O\nthen O\nseek O\nthe O\nendorsement O\nof O\nthe O\n185-members O\nGeneral B-ORG\nAssembly I-ORG\nbefore O\nDecember O\n31 O\nwhen O\nBoutros-Ghali B-PER\n's O\nterm O\nexpires O\n. O\n\n-DOCSTART- O\n\nSpain B-LOC\n's O\npolice O\nseize O\npetrol O\nbombs O\n, O\narrest O\nfive O\n. O\n\nMADRID B-LOC\n1996-12-06 O\n\nSpanish B-MISC\npolice O\nsaid O\non O\nFriday O\nthey O\nhad O\narrested O\nfive O\npeople O\nand O\nseized O\nmore O\nthan O\n90 O\npetrol O\nbombs O\nduring O\ndisturbances O\nafter O\na O\nprotest O\nin O\nthe O\nBasque B-MISC\ncountry O\nagainst O\nSpain B-LOC\n's O\nconstitution O\n. O\n\nHooded O\nprotesters O\nthrew O\nburning O\nbottles O\nand O\nother O\nobjects O\nat O\npolice O\nin O\nPamplona B-LOC\nafter O\nthe O\nprotest O\norganised O\nby O\nHerri B-ORG\nBatasuna I-ORG\n, O\nthe O\npolitical O\nwing O\nof O\nBasque B-MISC\nseparatist O\ngroup O\nETA B-ORG\n. O\n\nPolice O\nalso O\nconfiscated O\neight O\nkg O\n( O\n18 O\nlb O\n) O\nof O\nscrews O\n, O\nbalaclavas O\nand O\nspray O\npaint O\ncans O\n. O\n\nThe O\nprotest O\n, O\nwhich O\nattracted O\nseveral O\nthousand O\nsupporters O\n, O\ncoincided O\nwith O\nthe O\n18th O\nanniversary O\nof O\nSpain B-LOC\n's O\nconstitution O\n. O\n\n-DOCSTART- O\n\nMussolini B-PER\n's O\ngranddaughter O\nrejoins O\nfar-right O\nparty O\n. O\n\nROME B-LOC\n1996-12-06 O\n\nAlessandra B-PER\nMussolini I-PER\n, O\nthe O\ngranddaughter O\nof O\nItaly B-LOC\n's O\nFascist O\ndictator O\nBenito B-PER\nMussolini I-PER\n, O\nsaid O\non O\nFriday O\nshe O\nhad O\nrejoined O\nthe O\nfar-right O\nNational B-ORG\nAlliance I-ORG\n( O\nAN B-ORG\n) O\nparty O\nshe O\nquit O\nover O\npolicy O\ndifferences O\nlast O\nmonth O\n. O\n\n\" O\nI O\n've O\ngone O\nback O\n, O\n\" O\nshe O\ntold O\na O\nradio O\nshow O\nshortly O\nafter O\nAN B-ORG\nleader O\nGianfranco B-PER\nFini I-PER\n, O\nwho O\nwas O\nbeing O\ninterviewed O\non O\nthe O\nprogramme O\n, O\nsaid O\nthe O\nrow O\nhad O\nbeen O\nresolved O\n. O\n\n\" O\nHe O\ndid O\nn't O\nwant O\nto O\nlose O\nme O\nand O\nI O\ndid O\nn't O\nwant O\nto O\nlose O\nhim O\n. O\n\" O\n\nFini B-PER\ntold O\nstate O\nradio O\nRAI B-LOC\nhe O\nmet O\nMussolini B-PER\nthanks O\nto O\nthe O\ngood O\noffices O\nof O\nGiuseppe B-PER\nTatarella I-PER\n, O\nAN B-ORG\n's O\nleader O\nin O\nthe O\nChamber B-ORG\nof I-ORG\nDeputies I-ORG\n( O\nlower O\nhouse O\n) O\n, O\nand O\nhad O\novercome O\ntheir O\ndifferences O\n. O\n\nMussolini B-PER\n, O\n33 O\n, O\nresigned O\nfrom O\nthe O\nparliamentary O\nparty O\ngroup O\nfor O\nwhat O\nshe O\nsaid O\nwere O\nstrictly O\npolitical O\nreasons O\n. O\n\nThe O\nfiery O\npolitician O\n, O\nwho O\nis O\nalso O\na O\nniece O\nof O\nscreen O\nstar O\nSophia B-PER\nLoren I-PER\n, O\nhad O\naccused O\nAN B-ORG\nleaders O\nof O\nstifling O\ninternal O\nparty O\ndebate O\n. O\n\nMussolini B-PER\n, O\nwho O\nsits O\nin O\nthe O\nChamber B-ORG\n, O\ntold O\nLa B-ORG\nStampa I-ORG\nnewspaper O\nlast O\nmonth O\nafter O\nquitting O\nAN B-ORG\n's O\nparliamentary O\nparty O\nthat O\nshe O\nwas O\nconsidering O\njoining O\nthe O\nneo-fascist O\nSocial B-ORG\nMovement I-ORG\n( O\nMS-Fiamma B-ORG\n) O\nformed O\nby O\nsome O\nof O\nthe O\nDuce O\n's O\nWorld B-MISC\nWar I-MISC\nTwo I-MISC\nfollowers O\n. O\n\n-DOCSTART- O\n\nGerman B-MISC\nSanta B-PER\nin O\nbank O\nnearly O\ngets O\narrested O\n. O\n\nHANOVER B-LOC\n, O\nGermany B-LOC\n1996-12-06 O\n\nA O\nSanta B-PER\nClaus I-PER\ndistributing O\npresents O\nto O\nworkers O\nin O\na O\nGerman B-MISC\nbank O\non O\nFriday O\nnearly O\nended O\nup O\nbehind O\nbars O\nwhen O\na O\npassing O\npolice O\npatrol O\nthought O\nhe O\nwas O\na O\nrobber O\nin O\ndisguise O\n. O\n\nThe O\nman O\n, O\ndoing O\nhis O\nrounds O\nin O\nthe O\nnorthern O\ncity O\nof O\nHanover B-LOC\non O\nthe O\nday O\nwhen O\nGerman B-MISC\nchildren O\ntraditionally O\nreceive O\nsmall O\npresents O\nfrom O\nSaint B-PER\nNicholas I-PER\n, O\nconvinced O\npolice O\neventually O\nthat O\nhe O\nwas O\ngenuine O\n. O\n\n-DOCSTART- O\n\nItaly B-LOC\ncommission O\nconcludes O\n1997 O\nbudget O\nexamination O\n. O\n\nROME B-LOC\n1996-12-06 O\n\nThe O\nItalian B-MISC\nupper O\nhouse O\nSenate B-ORG\nbudget O\ncommission O\nhas O\nconcluded O\nits O\nexamination O\nof O\nItaly B-LOC\n's O\n1997 O\nbudget O\n, O\nand O\nit O\nwill O\napprove O\nthe O\nmeasure O\nofficially O\nby O\nSaturday O\n. O\n\nFrom O\nTuesday O\n, O\nthe O\nfull O\nassembly O\nof O\nthe O\nSenate B-ORG\nwill O\nstart O\nits O\nexamination O\nof O\nthe O\nfinancial O\npackage O\n. O\n\n-- O\nMilan B-LOC\nnewsroom O\n+392 O\n66129502 O\n\n-DOCSTART- O\n\nEU B-ORG\n, O\nPoland B-LOC\nagree O\non O\noil O\nimport O\ntariffs O\n. O\n\nBRUSSELS B-LOC\n1996-12-06 O\n\nThe O\nEuropean B-ORG\nUnion I-ORG\nand O\nPoland B-LOC\nhave O\nresolved O\ndisagreements O\nover O\na O\nnew O\nPolish B-MISC\noil O\nimport O\nregime O\n, O\nthe O\nEuropean B-ORG\nCommission I-ORG\nsaid O\non O\nFriday O\n. O\n\nThe O\nEU B-ORG\nhad O\nobjected O\nto O\nincreases O\nin O\nPolish B-MISC\ntariffs O\non O\nimports O\nof O\ngasoline O\nand O\ngasoil O\nproducts O\nintroduced O\non O\nJanuary O\n1 O\n, O\n1996 O\n, O\nsaying O\nthey O\ncontravened O\nlevels O\nenvisaged O\nin O\nthe O\nso-called O\nEurope B-LOC\nAgreement O\nbetween O\nthe O\nEU B-ORG\nand O\nPoland B-LOC\n. O\n\nThe O\nincreases O\nwere O\naimed O\nat O\nprotecting O\nthe O\nPolish B-MISC\nmarket O\nwhile O\nhelping O\nto O\nmodernise O\nthe O\nlocal O\noil O\nindustry O\n. O\n\n\" O\nThe O\nEU B-ORG\nand O\nPoland B-LOC\nhave O\nnow O\nreached O\na O\nfinal O\nsettlement O\nregarding O\nissues O\nrelated O\nto O\nthe O\nPolish B-MISC\nimport O\nregime O\nin O\nthe O\noils O\nsector O\n, O\n\" O\nthe O\nCommission B-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\nUnder O\nthe O\nagreement O\n, O\nPoland B-LOC\nwill O\nabolish O\nall O\noil O\nimport O\ntariffs O\nby O\n2001 O\n, O\nremove O\nall O\noil O\nprice O\ncontrols O\nand O\nend O\nquantitative O\nrestrictions O\non O\nimports O\nby O\nJanuary O\n1 O\n, O\n1997 O\n. O\n\nThe O\nagreement O\nincludes O\nthe O\nearly O\nprivatisation O\nand O\nmodernisation O\nof O\nPolish B-MISC\noil O\nrefineries O\n, O\nwhich O\nwill O\nbe O\nobliged O\nto O\noffer O\nequal O\ntreatment O\nto O\nall O\nbuyers O\n. O\n\nThe O\nEU B-ORG\nand O\nPoland B-LOC\nwill O\nmonitor O\nthe O\nsettlement O\nat O\nsix-monthly O\nmeetings O\n. O\n\n-DOCSTART- O\n\nHindu B-MISC\nparty O\nforces O\nIndia B-LOC\nparliament O\nto O\nadjourn O\n. O\n\nNEW B-LOC\nDELHI I-LOC\n1996-12-06 O\n\nHindu B-MISC\nnationalists O\nforced O\nadjournment O\nof O\nIndia B-LOC\n's O\nlower O\nhouse O\nof O\nparliament O\non O\nFriday O\n, O\nin O\nprotest O\nagainst O\na O\nproposal O\nto O\nobserve O\na O\nminute O\n's O\nsilence O\nover O\nthe O\ndestruction O\nof O\na O\nmosque O\nby O\na O\nHindu B-MISC\nmob O\nin O\n1992 O\n. O\n\nMembers O\nof O\nthe O\nHindu B-MISC\nnationalist O\nBharatiya B-ORG\nJanata I-ORG\nParty I-ORG\n( O\nBJP B-ORG\n) O\nshouted O\npro-Hindu B-MISC\nslogans O\nin O\nthe O\nhouse O\nafter O\na O\ncommunist O\ndeputy O\nmade O\nthe O\nproposal O\nin O\nremembrance O\nof O\nthe O\nBabri O\nmosque O\n, O\nwhich O\nwas O\nrazed O\non O\nDecember O\n6 O\n, O\n1992 O\n. O\n\nThe O\nhouse O\nwas O\nfirst O\nadjourned O\nfor O\ntwo O\nhours O\n. O\n\nWhen O\nit O\nreconvened O\n, O\nBJP B-ORG\ndeputies O\nresumed O\nthe O\nslogan-shouting O\n, O\nand O\ndeputy O\nspeaker O\nSuraj B-PER\nBhan I-PER\nsuspended O\nwork O\nuntil O\nMonday O\n. O\n\nThe O\ndestruction O\nof O\nthe O\n16th-century O\nmosque O\nin O\nthe O\nnorthern O\nIndian B-MISC\ntown O\nof O\nAyodhya B-LOC\ntriggered O\nnationwide O\nHindu-Moslem B-MISC\nviolence O\nin O\nwhich O\nmore O\nthan O\n3,000 O\npeople O\nwere O\nkilled O\n. O\n\nIndian B-MISC\nofficials O\nblame O\nrevenge-minded O\nMoslem B-MISC\nunderworld O\ngangs O\nin O\nBombay B-LOC\nfor O\na O\nstring O\nof O\nbombings O\nin O\nthe O\ncity O\nthree O\nmonths O\nlater O\nthat O\nkilled O\n260 O\npeople O\n. O\n\nThe O\nBJP B-ORG\nbacks O\na O\nhardline O\nHindu B-MISC\ncampaign O\nto O\nbuild O\na O\ntemple O\nat O\nthe O\nsite O\nof O\nthe O\nmosque O\n, O\nwhich O\nHindus B-MISC\nbelieve O\nwas O\nthe O\nbirthplace O\nof O\nthe O\nLord O\nRama B-PER\n. O\n\nThe O\ncampaign O\ncatapulted O\nBJP B-ORG\nfrom O\nthe O\npolitical O\nfringe O\nto O\nbecome O\nIndia B-LOC\n's O\nmain O\nopposition O\nparty O\nin O\n1991 O\n. O\n\n-DOCSTART- O\n\nIndian B-MISC\nSept O\ncrude O\noil O\noutput O\nfalls O\nto O\n2.6 O\nmln O\nT O\n. O\n\nNEW B-LOC\nDELHI I-LOC\n1996-12-06 O\n\nIndia B-LOC\n's O\ncrude O\npetroleum O\noutput O\nfell O\nto O\n2.56 O\nmillion O\ntonnes O\nin O\nSeptember O\nfrom O\n2.83 O\nmillion O\nin O\nthe O\nsame O\nmonth O\nin O\n1995 O\n, O\nthe O\ngovernment O\nsaid O\non O\nFriday O\n. O\n\nSTEEL O\nOUTPUT O\nSept O\nSept O\nApr-Sept O\nApr-Sept O\n\n1996 O\n1995 O\n1996 O\n1995 O\n\nCrude O\npetroleum O\n2,557 O\n2,832 O\n15,838 O\n17,648 O\n\nPetroleum O\nproducts O\n4,605 O\n5,110 O\n30,589 O\n29,328 O\n\nNote O\n- O\nFigures O\nare O\nin O\nthousands O\nof O\ntonnes O\nand O\npreliminary O\n. O\n\n-DOCSTART- O\n\nLUXEMBOURG B-LOC\nCHRISTMAS O\nMARKET O\nGOES O\nON O\nWORLD O\nWIDE O\nWEB O\n. O\n\nBRUSSELS B-LOC\n1996-12-06 O\n\nLuxembourg B-LOC\n's O\ntraditional O\nChristmas O\nmarket O\n, O\nwhich O\nstarts O\non O\nSaturday O\nand O\nruns O\nto O\nDecember O\n24 O\n, O\nhas O\ntaken O\nto O\nthe O\nworld O\nwide O\nweb O\nas O\na O\nway O\nof O\npublicising O\nits O\nactivities O\n. O\n\nThe O\nweb O\nsite O\n( O\nhttp://www.pt.lu/infoweb/kreschtmaart O\n) O\ngives O\ndetails O\nof O\nthe O\nmarket O\n's O\nconcert O\nprogramme O\nas O\nwell O\nas O\nits O\nvarious O\nretailers O\n. O\n\n-- O\nBrussels B-ORG\nNewsroom I-ORG\n+32 O\n2 O\n287 O\n6810 O\n, O\nFax O\n+32 O\n2 O\n230 O\n7710 O\n\n-DOCSTART- O\n\nLondon B-LOC\ncoal O\n/ O\nore O\nfixtures O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nCOAL O\n- O\nLantau B-MISC\nPeak I-MISC\n- O\n120,000 O\ntones O\ncoal O\nHay B-LOC\nPoint I-LOC\nor O\nNewcastle B-LOC\n/ O\nKaohsiung B-LOC\n20-30/1 O\n$ O\n5.25 O\nand O\n$ O\n5.85 O\nfio O\nrespectively O\n40,000-35,000 O\n/ O\n28,000 O\nshinc O\nChina B-ORG\nSteel I-ORG\n. O\n\nRoyal B-MISC\nClipper I-MISC\n- O\n77,000 O\ntonnes O\ncoal O\nMaracaibo B-LOC\n/ O\nFos B-LOC\n19/12-2/1 O\n$ O\n9.90 O\nfio O\n20,000 O\nshinc O\n/ O\n25,000 O\nshinc O\nCoe B-ORG\nand I-ORG\nClerici I-ORG\n. O\n\nORE O\n- O\nIMC O\nTBN O\n- O\n70,000 O\ntonnes O\nDampier B-LOC\n/ O\nKaohsiung B-LOC\n20-30/12 O\n$ O\n5.25 O\nfio O\n35,000 O\nshinc O\n/ O\n30,000 O\nshinc O\nChina B-ORG\nSteel I-ORG\n. O\n\n-DOCSTART- O\n\nUK B-LOC\nbookmakers O\nlengthen O\nConservative B-MISC\nvictory O\nodds O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nUK B-LOC\nbookmakers O\nWilliam B-PER\nHill I-PER\nsaid O\non O\nFriday O\nthey O\nhave O\nlengthened O\nthe O\nodds O\nof O\na O\nConservative B-MISC\nvictory O\nin O\nthe O\nnext O\ngeneral O\nelection O\nfrom O\n9-4 O\nto O\n5-2 O\n. O\n\nWilliam B-PER\nHill I-PER\nsaid O\nthe O\nodds O\nwere O\nthe O\nlongest O\nthey O\nhad O\nbeen O\nfor O\nsix O\nmonths O\n. O\n\nThe O\nLabour B-ORG\nopposition O\nare O\nnow O\n1-4 O\nfavourites O\n, O\nit O\nsaid O\n. O\n\nThe O\nelection O\nmust O\nbe O\nheld O\nby O\nMay O\n. O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542-7768 O\n\n-DOCSTART- O\n\nItaly B-LOC\ntops O\nweek O\nof O\nmeagre O\nbond O\nreturns O\n- O\nSalomon B-ORG\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nHigh-flying O\nItaly B-LOC\ntopped O\nthe O\nleague O\nin O\na O\nweek O\nof O\nmeagre O\nreturns O\non O\ngovernment O\nbonds O\n, O\nSalomon B-ORG\nBrothers I-ORG\nsaid O\non O\nFriday O\n. O\n\nIn O\nlocal O\ncurrency O\nterms O\n, O\nItalian B-MISC\nBTPs O\noffered O\nreturns O\nof O\n0.85 O\npercent O\nin O\nthe O\nweek O\nended O\non O\nThursday O\n, O\nwith O\nfellow O\nhigh-yielder O\nSweden B-LOC\nclose O\nbehind O\non O\n0.80 O\npercent O\n. O\n\nThe O\nweekly O\ngovernment O\nbond O\nindex O\nrose O\n0.07 O\npercent O\nin O\nlocal O\ncurrency O\nterms O\n. O\n\nFrance B-LOC\nmanaged O\nthird O\nplace O\nwith O\n0.68 O\npercent O\nin O\nthe O\n16-nation O\nworld O\ngovernment O\nbond O\nindex O\n. O\n\nCanada B-LOC\n's O\nwere O\nthe O\nworst O\nperforming O\nbonds O\n. O\n\nThey O\nlost O\n2.21 O\npercent O\n, O\ndepressed O\nby O\na O\nwave O\nof O\nnew O\nCanadian B-MISC\nsupply O\n. O\n\nReturns O\non O\nTreasuries B-MISC\nwere O\nalso O\nin O\nnegative O\nterritory O\nat O\nminus O\n0.24 O\npercent O\n, O\nthe O\npoorest O\nresult O\nafter O\nCanada B-LOC\nand O\nBritish B-MISC\ngilts O\nwhich O\nlost O\n0.28 O\npercent O\n. O\n\nAustralia B-LOC\nwas O\nthe O\nonly O\ndollar-bloc O\ncountry O\nin O\nthe O\ntable O\nto O\neke O\nout O\na O\npositive O\nreturn O\n, O\nalbeit O\na O\npaltry O\n0.02 O\npercent O\n. O\n\nGerman B-MISC\nBunds O\nwere O\nnot O\nmuch O\nbetter O\n, O\noffering O\nreturns O\nof O\n0.05 O\npercent O\n, O\nwhile O\nJapanese B-MISC\ngovernment O\nbonds O\nmanaged O\na O\n0.38 O\npercent O\ngain O\n. O\n\nSpanish B-MISC\nbonds O\n, O\nwhich O\nhad O\nbeen O\ntop O\nperformers O\nin O\nSalomon B-ORG\nBrothers I-ORG\n' O\nleague O\ntable O\nfor O\nNovember O\nas O\na O\nwhole O\n, O\nturned O\nin O\na O\nmore O\nsubdued O\nweekly O\nperformance O\nwith O\na O\nreturn O\nof O\nonly O\n0.27 O\npercent O\n. O\n\nIn O\nU.S. B-LOC\ndollar O\nterms O\n, O\nJapan B-LOC\nwas O\nthe O\nonly O\ncountry O\nto O\ngive O\npositive O\nreturns O\nat O\n1.35 O\npercent O\n. O\n\nFrance B-LOC\nlost O\n0.37 O\npercent O\n, O\nfollowed O\nby O\nItaly B-LOC\non O\nminus O\n0.59 O\npercent O\n. O\n\nThe O\nbiggest O\nlosers O\nin O\ndollar O\nterms O\nwere O\nBritish B-MISC\ngilts O\n, O\nwhich O\nshed O\n3.41 O\npercent O\n, O\nCanada B-LOC\nwith O\nminus O\n3.03 O\npercent O\nand O\nAustralia B-LOC\nat O\nminus O\n1.54 O\npercent O\n. O\n\nSalomon B-ORG\n's O\nbond O\nindex O\nis O\ncalculated O\nusing O\nall O\ngovernment O\nbonds O\nwith O\nover O\none O\nyear O\nto O\nmaturity O\n, O\nweighted O\nfor O\nmarket O\ncapitalisation O\n. O\n\nOnly O\nbonds O\nfreely O\navailable O\nto O\ninstitutional O\ninvestors O\nand O\nwith O\na O\ncertain O\nminimum O\namount O\noutstanding O\nare O\nincluded O\n. O\n\nReturns O\ntake O\naccount O\nof O\nprice O\nmoves O\nand O\naccrued O\ninterest O\n. O\n\n-- O\nStephen B-PER\nNisbet I-PER\n, O\nInternational B-ORG\nBonds I-ORG\n+44 O\n171 O\n6320 O\n\n-DOCSTART- O\n\nOPEC B-ORG\nbasket O\nprice O\n$ O\n24.20 O\non O\nThursday O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nThe O\nprice O\nof O\nthe O\nOPEC B-ORG\nbasket O\nof O\nseven O\ncrudes O\nstood O\nat O\n$ O\n24.20 O\na O\nbarrel O\non O\nThursday O\n, O\nagainst O\n$ O\n23.47 O\non O\nWednesday O\n, O\nthe O\nOPECNA B-ORG\nnews O\nagency O\nsaid O\n, O\nquoting O\nthe O\nOPEC B-ORG\nsecretariat O\n. O\n\nThe O\nbasket O\ncomprises O\nAlgeria B-LOC\n's O\nSaharan B-MISC\nBlend I-MISC\n, O\nIndonesia B-LOC\n's O\nMinas B-MISC\n, O\nNigeria B-LOC\n's O\nBonny B-MISC\nLight I-MISC\n, O\nSaudi B-LOC\nArabia I-LOC\n's O\nArabian B-MISC\nLight I-MISC\n, O\nDubai B-MISC\nof O\nthe O\nUAE B-LOC\n, O\nVenezuela B-LOC\n's O\nTia B-MISC\nJuana I-MISC\nand O\nMexico B-LOC\n's O\nIsthmus B-MISC\n. O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n7630 O\n\n-DOCSTART- O\n\nRelations O\nbetween O\nClarke B-PER\n, O\nMajor B-PER\ngood O\n- O\nspokesman O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nRelations O\nbetween O\nChancellor O\nof O\nthe O\nExchequer O\nKenneth B-PER\nClarke I-PER\nand O\nPrime O\nMinister O\nJohn B-PER\nMajor I-PER\nare O\ngood O\ndespite O\nmedia O\nreports O\nof O\na O\nrift O\nover O\nEuropean B-MISC\npolicy O\n, O\na O\nspokesman O\nfor O\nMajor B-PER\n's O\noffice O\nsaid O\non O\nFriday O\n. O\n\nAsked O\nabout O\nthe O\nreports O\n, O\nthe O\nspokesman O\nsaid O\n: O\n\" O\nRelations O\nare O\ngood O\n. O\n\" O\n\nAsked O\nabout O\nMajor B-PER\n's O\nmood O\nafter O\na O\nday O\nof O\nmedia O\nspeculation O\nabout O\nhis O\npolitical O\nfortunes O\n, O\nthe O\nspokesman O\nsaid O\n: O\n\" O\nHe O\nis O\nresolute O\n. O\n\nHe O\nis O\ngetting O\non O\nwith O\nthe O\njob O\n. O\n\" O\n\nThe O\nspokesman O\nsaid O\nhe O\nwas O\nnot O\naware O\nof O\nany O\nmeetings O\novernight O\nbetween O\nClarke B-PER\nand O\nMajor B-PER\n, O\nnor O\nof O\nany O\ntalks O\nbetween O\nthe O\nprime O\nminister O\nand O\nparliamentary O\nbusiness O\nmanagers O\n. O\n\nBoth O\nMajor B-PER\nand O\nClarke B-PER\nwere O\nin O\ntheir O\nconstituencies O\non O\nFriday O\n. O\n\n-DOCSTART- O\n\nTwo O\ndead O\nafter O\nexecutive O\njet O\ncrashes O\nin O\nNewfoundland B-LOC\n. O\n\nSTEPHENVILLE B-LOC\n, O\nNewfoundland B-LOC\n1996-12-06 O\n\nTwo O\npeople O\nwere O\nkilled O\nwhen O\nan O\nexecutive O\njet O\nen O\nroute O\nto O\nIreland B-LOC\nfrom O\nMichigan B-LOC\ncrashed O\non O\napproach O\nto O\nan O\nairport O\nin O\nStephenville B-LOC\n, O\nNewfoundland B-LOC\n, O\non O\nFriday O\n, O\nauthorities O\nsaid O\n. O\n\nThe O\npilot O\nand O\nco-pilot O\n, O\nthe O\nonly O\ntwo O\naboard O\n, O\nwere O\nkilled O\nin O\nthe O\ncrash O\nof O\nthe O\nLearjet B-MISC\n36 I-MISC\n, O\nairport O\nmanager O\nDavid B-PER\nSnow I-PER\nsaid O\nin O\na O\ntelephone O\ninterview O\n. O\n\nSnow B-PER\nsaid O\nthe O\nplane O\nlast O\nreported O\nto O\nair O\ntraffic O\ncontrol O\nat O\nabout O\n3 O\nA.M. O\nlocal O\ntime O\n/ O\n1:30 O\nA.M. O\nEST O\n( O\n0630 O\nGMT B-MISC\n) O\nwhen O\nit O\nbegan O\nits O\nfinal O\napproach O\nabout O\n10 O\nmiles O\n( O\n16 O\nkm O\n) O\nfrom O\nthe O\nairport O\nin O\nthis O\neast O\ncoast O\nCanadian B-MISC\nprovince O\n. O\n\nThat O\nwas O\nthe O\nlast O\ncommunication O\nthe O\naircraft O\nmade O\nwith O\nthe O\nairport O\n, O\nhe O\nadded O\n. O\n\n\" O\nWe O\nconsidered O\nit O\nas O\nbeing O\nmissing O\nuntil O\nabout O\n0600 O\n( O\n4:30 O\nA.M. O\nEST O\n) O\n( O\n0930 O\nGMT B-MISC\n) O\n. O\n\nThat O\n's O\nwhen O\nthe O\nwreckage O\nwas O\ndiscovered O\n, O\n\" O\nSnow B-PER\nsaid O\n. O\n\nHe O\nsaid O\nthe O\ncargo O\nflight O\noriginated O\nin O\nGrand B-LOC\nRapids I-LOC\n, O\nMichigan B-LOC\n, O\nand O\nwas O\ndue O\nto O\nstop O\nat O\nStephenville B-LOC\nfor O\nrefueling O\nbefore O\ngoing O\nto O\nShannon B-LOC\n, O\nIreland B-LOC\n. O\n\nThe O\ncause O\nof O\nthe O\ncrash O\nwas O\nnot O\nyet O\nknown O\n. O\n\nInvestigators O\nwere O\ndue O\nto O\nfly O\nto O\nStephenville B-LOC\nlater O\non O\nFriday O\n. O\n\n-DOCSTART- O\n\nPLO B-ORG\nsays O\nArafat B-PER\n, O\nNetanyahu B-PER\ncould O\nmeet O\nSaturday O\n. O\n\nJERUSALEM B-LOC\n1996-12-06 O\n\nPLO B-ORG\nnegotiators O\nsaid O\non O\nFriday O\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\n, O\nIsraeli B-MISC\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\nand O\nEgyptian B-MISC\nPresident O\nHosni B-PER\nMubarak I-PER\nmight O\nall O\nmeet O\non O\nSaturday O\nto O\ntry O\nto O\nclinch O\na O\ndeal O\non O\nIsrael B-LOC\n's O\nhandover O\nof O\nHebron B-LOC\nto O\nthe O\nPLO B-ORG\n. O\n\n\" O\nIt O\nis O\nvery O\npossible O\nthat O\nArafat B-PER\nand O\nNetanyahu B-PER\nwill O\nmeet O\nin O\nCairo B-LOC\non O\nSaturday O\n. O\n\nThere O\nis O\nwork O\non O\narranging O\nsuch O\na O\nmeeting O\nhosted O\nby O\nPresident O\nMubarak B-PER\n, O\n\" O\none O\nPLO B-ORG\nofficial O\n, O\nwho O\nrequested O\nanonymity O\n, O\ntold O\nReuters B-ORG\n. O\n\nIsraeli B-MISC\nofficials O\nsaid O\nno O\nmeeting O\nhad O\nyet O\nbeen O\nset O\n. O\n\nArafat B-PER\n's O\nadviser O\nNabil B-PER\nAbu I-PER\nRdainah I-PER\nsaid O\n: O\n\n\" O\nPresident O\nArafat B-PER\nis O\nready O\nto O\nmeet O\nPrime O\nMinister O\nNetanyahu B-PER\nbut O\nno O\ntime O\nor O\ndate O\nhas O\nbeen O\nset O\nfor O\nsuch O\na O\nmeeting O\nyet O\n. O\n\n\" O\nPresident O\nArafat B-PER\n's O\nposition O\nis O\nclear O\nthat O\nsuch O\na O\nmeeting O\nshould O\ncome O\nafter O\nsuccessful O\nnegotiations O\nso O\nthat O\nthe O\nmeeting O\nwould O\nhave O\npositive O\nresults O\n. O\n\nEspecially O\nsince O\nthe O\nHebron B-LOC\nissue O\nhas O\nnot O\nbeen O\nagreed O\nyet O\nand O\nthe O\ncrucial O\ndisputed O\nissues O\nhave O\nnot O\nbeen O\nresolved O\n. O\n\" O\n\nBut O\nRdainah B-PER\nsaid O\nArafat B-PER\nwould O\ngo O\nto O\nCairo B-LOC\non O\nSaturday O\nfor O\ntalks O\nwith O\nMubarak B-PER\n. O\n\nBoth O\nArafat B-PER\nand O\nNetanyahu B-PER\nhave O\nexpressed O\nwillingness O\nto O\nmeet O\n. O\n\nThey O\nlast O\nmet O\nin O\nWashington B-LOC\nafter O\nclashes O\nin O\nSeptember O\nthat O\nkilled O\n60 O\nPalestinians B-MISC\nand O\n15 O\nIsraelis B-MISC\n. O\n\nThe O\nviolence O\nwas O\nspurred O\nby O\nIsrael B-LOC\n's O\nopening O\nan O\nentrance O\nto O\na O\ntunnel O\nnear O\nMoslem B-MISC\nsites O\nin O\nJerusalem B-LOC\n. O\n\nThe O\nPalestine B-ORG\nLiberation I-ORG\nOrganisation I-ORG\n( O\nPLO B-ORG\n) O\nnegotiators O\nsaid O\nthe O\nlast O\ntwo O\nweeks O\nof O\ntalks O\nwith O\nIsrael B-LOC\non O\nimplementing O\nthe O\nlong-delayed O\nhandover O\nof O\nmost O\nof O\nHebron B-LOC\nto O\nPLO B-ORG\nrule O\nhad O\nbeen O\n\" O\nmeaningless O\n\" O\n, O\nnecessitating O\nan O\nArafat-Netanyahu O\nmeeting O\n. O\n\nMubarak B-PER\n's O\nadviser O\nOsama B-PER\nel-Baz I-PER\nsaid O\non O\nThursday O\nthere O\nwere O\nefforts O\nto O\narrange O\na O\nmeeting O\nbetween O\nthe O\nIsraeli B-MISC\nand O\nPalestinian B-MISC\nleaders O\n. O\n\nPalestinian B-ORG\nAuthority I-ORG\nSecretary O\nGeneral O\nAhmed B-PER\nAbdel-Rahman I-PER\nsaid O\non O\nThursday O\nhe O\nunderstood O\nit O\ncould O\nbe O\nheld O\nin O\nCairo B-LOC\neither O\non O\nFriday O\nor O\nSunday O\n. O\n\nAbdel-Rahman B-PER\nhad O\nsaid O\non O\nThursday O\nhe O\ndid O\nnot O\nthink O\nSaturday O\nwould O\nbe O\nthe O\ndate O\nbecause O\nit O\nis O\nthe O\nJewish B-MISC\nsabbath O\n. O\n\nBut O\nthe O\nJewish B-MISC\nsabbath O\nends O\nat O\nsundown O\n, O\nso O\na O\nnight O\nmeeting O\nwould O\nnot O\ninterfere O\nwith O\nthe O\nreligious O\nobservance O\n. O\n\n-DOCSTART- O\n\nTurkey B-LOC\nhindered O\nby O\nown O\nlandmines O\non O\nSyrian B-MISC\nborder O\n. O\n\nANKARA B-LOC\n1996-12-06 O\n\nTurkey B-LOC\n's O\nefforts O\nto O\nprevent O\nKurdish B-MISC\nrebels O\nand O\nsmugglers O\ninfiltrating O\nfrom O\nSyria B-LOC\nare O\nbeing O\nbadly O\nhindered O\nbecause O\nthe O\nmilitary O\ndoes O\nnot O\nhave O\na O\nmap O\nof O\nits O\nown O\nminefields O\non O\nthe O\nborder O\n, O\na O\ncommission O\nof O\nparliamentarians O\nsaid O\n. O\n\n\" O\nIt O\nis O\nnot O\nknown O\nexactly O\nwhere O\nthe O\nmines O\nhave O\nbeen O\nsown O\nbecause O\na O\nminefield O\nchart O\ncannot O\nbe O\nfound O\n, O\n\" O\nthe O\ncommission O\nsaid O\nin O\na O\nreport O\non O\nborder O\nprotection O\n. O\n\nThe O\nreport O\n, O\nto O\nbe O\ndebated O\nin O\nparliament O\nin O\ncoming O\nweeks O\n, O\nwas O\nseen O\nby O\nReuters B-ORG\non O\nFriday O\n. O\n\" O\n\nOfficials O\nsay O\nthe O\nminefields O\npresent O\nan O\nobstacle O\nto O\nthe O\nsecurity O\nforces O\n, O\n\" O\nit O\nsaid O\n. O\n\nIt O\nsaid O\nKurdistan B-ORG\nWorkers I-ORG\nParty I-ORG\n( O\nPKK B-ORG\n) O\nguerrillas O\nsometimes O\nknow O\nthe O\nlayout O\nof O\nmined O\nareas O\nalong O\nthe O\nborder O\nbetter O\nthan O\nthe O\nsecurity O\nforces O\n. O\n\n\" O\nTerrorists O\nand O\nsmugglers O\nhave O\ndug O\nup O\nthe O\nmines O\n, O\ndefused O\nthem O\nand O\nopened O\nup O\nwide O\npaths O\nin O\nsome O\nareas O\n. O\n\nThey O\ncan O\ncome O\nin O\nand O\nout O\neasily O\nas O\nthe O\nminefields O\nare O\nnot O\nan O\nobstacle O\n, O\n\" O\nit O\nsaid O\n. O\n\nAn O\narmed O\nforces O\nspokesman O\nwas O\nnot O\navailable O\nfor O\ncomment O\n. O\n\nTurkey B-LOC\nsays O\nSyria B-LOC\nsponsors O\nthe O\nPKK B-ORG\n, O\nfighting O\nfor O\nKurdish B-MISC\nself-rule O\nin O\nsoutheast O\nTurkey B-LOC\n. O\n\nDamascus B-LOC\ndenies O\naiding O\nthe O\nrebels O\n. O\n\nThe O\nPKK B-ORG\nalso O\ncrosses O\ninto O\nTurkey B-LOC\nfrom O\nbases O\nin O\nthe O\nmountains O\nof O\nnorthern O\nIraq B-LOC\n. O\n\nMore O\nthan O\n21,000 O\npeople O\nhave O\ndied O\nin O\nthe O\n12-year-old O\nconflict O\n. O\n\n-DOCSTART- O\n\nThree O\ndead O\nin O\nKurd B-MISC\nmilitia O\nblood O\nfeud O\nin O\nTurkey B-LOC\n. O\n\nDIYARBAKIR B-LOC\n, O\nTurkey B-LOC\n1996-12-06 O\n\nThree O\npeople O\nwere O\nkilled O\non O\nFriday O\nin O\na O\ngun O\nbattle O\nbetween O\nrival O\ngroups O\nof O\nanti-guerrilla O\nmilitiamen O\non O\nthe O\nstreets O\nof O\nthis O\nsoutheastern O\nTurkish B-MISC\ncity O\n, O\npolice O\nsaid O\n. O\n\nFour O\nothers O\nwere O\nwounded O\nin O\nthe O\nclash O\n, O\ncaused O\nby O\na O\nblood O\nfeud O\nbetween O\ntwo O\nfamilies O\n, O\nthe O\nKesers B-PER\nand O\nKarabuluts B-PER\n, O\nserving O\nas O\nstate-paid O\nvillage O\nguards O\nagainst O\nKurdish B-MISC\nrebels O\n. O\n\nPolice O\nsaid O\nthe O\nguards O\nfired O\nautomatic O\nweapons O\nat O\neach O\nother O\n. O\n\nOne O\nof O\nthe O\ndead O\nwas O\na O\ncivilian O\npasser-by O\n. O\n\nThe O\nrole O\nof O\nthe O\n70,000 O\nmainly O\nKurdish B-MISC\nvillage O\nguards O\nwho O\nfight O\nKurdistan B-ORG\nWorkers I-ORG\nParty I-ORG\n( O\nPKK B-ORG\n) O\nguerrillas O\nin O\nthe O\nsoutheast O\nhas O\nbeen O\nquestioned O\nrecently O\nafter O\nmedia O\nallegations O\nthat O\nmany O\nof O\nthem O\nare O\ninvolved O\nin O\ncommon O\ncrime O\n. O\n\nThe O\nhead O\nof O\nthe O\nregion O\n's O\nmain O\npro-state O\nmilitia O\nis O\nat O\nthe O\ncentre O\nof O\na O\nsecurity O\nscandal O\nthat O\nhas O\nshaken O\nthe O\ngovernment O\n. O\n\nMore O\nthan O\n21,000 O\npeople O\nhave O\nbeen O\nkilled O\nin O\nthe O\n12-year-old O\nconflict O\nbetween O\nTurkish B-MISC\nsecurity O\nforces O\nand O\nthe O\nPKK B-ORG\n, O\nfighting O\nfor O\nKurdish B-MISC\nautonomy O\nor O\nindependence O\n. O\n\n-DOCSTART- O\n\nTexas B-LOC\n/ O\nw O\nOkla B-LOC\nfed O\ncattle O\nroundup O\n- O\nUSDA B-ORG\n. O\n\nAMARILLO B-LOC\n1996-12-06 O\n\nTrade O\nvery O\nslow O\nin O\nthe O\nPanhandle B-LOC\narea O\nThursday O\n. O\n\nSlaughter O\nsteers O\nand O\nheifers O\nnot O\nwell O\ntested O\n. O\n\nFeedlots O\nreporting O\nlight O\ninquiry O\nfrom O\nbuyers O\n. O\n\n- O\nUSDA B-ORG\n\nThursday O\n200 O\nWeek O\nAgo O\nHoliday O\nYear O\nAgo O\n10,900 O\n\nWk O\nto O\nDate O\n69,100 O\nWeek O\nAgo O\n58,100 O\nYear O\nAgo O\n30,800 O\n\nSales O\nreported O\non O\n200 O\nhead O\nsteers O\n; O\n69,100 O\nhead O\nconfirmed O\nfor O\nweek O\nto O\ndate O\nwhich O\nincludes O\n14,000 O\nformulated O\nand O\n3,400 O\ncontracted O\ncattle O\nto O\nbe O\nshipped O\nthis O\nweek O\n. O\n\nSlaughter O\nSteers O\n: O\nPen O\nSelect O\nand O\nChoice O\n2-3 O\n, O\n1150 O\nlbs O\n67.00 O\n. O\n\nPen O\nSelect O\n, O\nfew O\nchoice O\n2-3 O\n1150 O\nlbs O\n66.00 O\n. O\n\n-DOCSTART- O\n\nKansas B-LOC\nfeedlot O\ncattle O\nroundup O\n- O\nUSDA B-ORG\n. O\n\nDODGE B-LOC\nCITY I-LOC\n1996-12-06 O\n\nTrade O\nslow O\n. O\n\nNot O\nenough O\nslaughter O\nsteer O\nor O\nheifer O\nsales O\nconfirmed O\nfor O\nan O\nadequate O\nmarket O\ntest O\n. O\n\n- O\nUSDA B-ORG\n\nThursday O\n600 O\nweek O\nago O\nholiday O\nyear O\nago O\n14,200 O\n\nweek O\nto O\ndate O\n89,300 O\nweek O\nago O\n71,000 O\nyear O\nago O\n47,200 O\n\nInquiry O\ngood O\n, O\ndemand O\nlight O\n. O\n\nSales O\nconfirmed O\non O\n500 O\nslaughter O\nsteers O\nand O\n100 O\nslaughter O\nheifers O\nThursday O\n. O\n\nFor O\nthe O\nweek O\nto O\ndate O\n89,300 O\nhead O\nconfirmed O\nincluding O\n30,600 O\nhead O\nof O\ncontracted O\nor O\nformulated O\ncattle O\n. O\n\nSteers O\n: O\nSelect O\nand O\nChoice O\n2-3 O\n, O\n1200 O\nlbs O\n67.00 O\n. O\n\nHeifers O\n: O\nSelect O\nand O\nChoice O\n2-3 O\n, O\n1150 O\nlbs O\n67.00 O\n. O\n\n-DOCSTART- O\n\nDelphis B-ORG\nHanover I-ORG\nweekly O\nmunicipal O\nbond O\nyields O\n. O\n\nDelphis B-ORG\nHanover I-ORG\nweekly O\nmuni O\nbond O\nyields O\ncalculated O\nDec O\n5 O\n\nAaa O\nAa O\nA O\nBaa O\n\n1997 O\n3.50 O\n3.60* O\n3.70 O\n3.75 O\n4.00 O\n4.00 O\n4.30 O\n4.35 O\n\n2001 O\n4.20 O\n4.20 O\n4.35 O\n4.40 O\n4.65 O\n4.65 O\n5.00 O\n5.00 O\n\n2006 O\n4.70 O\n4.70 O\n4.85 O\n4.85 O\n5.15 O\n5.15 O\n5.50 O\n5.50 O\n\n2011 O\n5.15 O\n5.15 O\n5.30 O\n5.30 O\n5.60 O\n5.60 O\n5.90 O\n5.90 O\n\n2016 O\n5.35 O\n5.30 O\n5.50 O\n5.45 O\n5.80 O\n5.75 O\n6.10 O\n6.05 O\n\n2021 O\n5.45 O\n5.40 O\n5.60 O\n5.55 O\n5.90 O\n5.85 O\n6.20 O\n6.15 O\n\n2026 O\n5.50 O\n5.45 O\n5.65 O\n5.60 O\n5.95 O\n5.90 O\n6.25 O\n6.20 O\n\n*from O\nprevious O\ncalculation O\non O\nNov O\n27 O\n\n-- O\nU.S. B-ORG\nMunicipal I-ORG\nDesk I-ORG\n, O\n212-859-1650 O\n\n-DOCSTART- O\n\nACCESS B-MISC\nenergy O\nfutures O\nprices O\nadd O\nto O\ndaytime O\ngains O\n. O\n\nLOS B-ORG\nANGELES I-ORG\n1996-12-05 O\n\nU.S. B-LOC\nenergy O\nfutures O\nadded O\nto O\nfloor O\nsession O\ngains O\nin O\nlight O\nNYMEX B-MISC\nACCESS I-MISC\ntrade O\nThursday O\n, O\nas O\nforecasts O\nfor O\ncolder O\ntemperatures O\nin O\ndistillate-hungry O\nNortheastern O\nmarkets O\nraised O\nsupply O\nconcerns O\n. O\n\n\" O\nThe O\ncold O\nweather O\nforecasts O\nare O\nhelping O\nright O\nnow O\n, O\n\" O\na O\ntrader O\nsaid O\n. O\n\nEarlier O\n, O\nNYMEX B-ORG\ncrude O\nended O\ndaytime O\ntrade O\n78 O\ncents O\nhigher O\nat O\n$ O\n25.58 O\na O\nbarrel O\n, O\nfollowing O\nbreakthroughs O\nof O\nkey O\ntechnical O\nlevels O\nand O\nreports O\nof O\ntighter O\nsupplies O\n. O\n\nFront-month O\nheating O\noil O\nfirmed O\n0.09 O\ncents O\na O\ngallon O\nto O\n75.20 O\ncents O\nas O\nroughly O\n100 O\nlots O\nchanged O\nhands O\nwithin O\nthe O\nfirst O\nfew O\nhours O\nof O\nACCESS B-MISC\n. O\n\nAbout O\n112 O\nlots O\nwere O\nexchanged O\noverall O\n, O\ntraders O\nsaid O\n. O\n\nNYMEX B-ORG\ngasoline O\nfor O\nJanuary O\ndelivery O\nclimbed O\n0.12 O\ncents O\na O\ngallon O\nto O\n69.80 O\ncents O\nas O\na O\nlight O\n33 O\nlots O\ntraded O\nin O\nthe O\nnearby O\nmonth O\nand O\n35 O\nmoved O\noverall O\n. O\n\nJanuary O\ncrude O\nwas O\nbarely O\nchanged O\nfrom O\nits O\nsettlement O\n, O\nedging O\nup O\none O\ncent O\nto O\n$ O\n25.66 O\na O\nbarrel O\n. O\n\nAbout O\n350 O\nlots O\nwere O\ntraded O\nfor O\nJanuary O\nand O\n870 O\nin O\nall O\nmonths O\n. O\n\n-- O\nDavid B-PER\nBrinkerhoff I-PER\n, O\nLos B-LOC\nAngeles I-LOC\nbureau O\n+1 O\n213 O\n380 O\n2014 O\n\n-DOCSTART- O\n\nU.S. B-LOC\nblasts O\nrelease O\nof O\nconvicted O\nbomber O\n. O\n\nWASHINGTON B-LOC\n1996-12-05 O\n\nThe O\nUnited B-LOC\nStates I-LOC\nThursday O\nblasted O\nthe O\nrelease O\nfrom O\na O\nGreek B-MISC\nprison O\nof O\na O\nPalestinian B-MISC\nguerrilla O\nconvicted O\nof O\nbombing O\nan O\nairliner O\nand O\nkilling O\na O\nteenager O\nin O\n1982 O\n, O\nsaying O\nthe O\nmove O\n\" O\ndoes O\nnot O\nmake O\nsense O\n. O\n\" O\n\n\" O\nAll O\nof O\nus O\nwho O\nhave O\nbeen O\nvictimised O\nby O\nterrorists O\n... O\nneed O\nto O\nstand O\ntogether O\nagainst O\nterrorists O\n. O\n\nWe O\nca O\nn't O\nlet O\nterrorists O\nout O\nof O\njail O\nwhen O\nthey O\nare O\na O\ndanger O\nto O\ncivilians O\nall O\naround O\nthe O\nworld O\n, O\n\" O\nState B-ORG\nDepartment I-ORG\nspokesman O\nNicholas B-PER\nBurns I-PER\nsaid O\n. O\n' O\n\nMohammed B-PER\nRashid I-PER\n\" O\nis O\na O\nterrorist O\nwho O\ndeserves O\nto O\nbe O\nbehind O\nbars O\n. O\n\nIt O\nis O\ninexplicable O\nto O\nus O\nwhy O\nhe O\nwould O\nhave O\nbeen O\nallowed O\nto O\nleave O\nGreece B-LOC\nbefore O\nserving O\nhis O\njust O\nsentence O\n... O\nThis O\nis O\nan O\nincomprehensible O\nmove O\n. O\n\nIt O\ndoes O\nnot O\nmake O\nsense O\n, O\n\" O\nBurns B-PER\ntold O\na O\nnews O\nbriefing O\n. O\n\nHe O\nspoke O\nafter O\nRashid B-PER\nleft O\nGreece B-LOC\nThursday O\non O\nbeing O\nfreed O\nfrom O\nprison O\nearly O\nfor O\ngood O\nbehaviour O\nafter O\nserving O\n8-1/2 O\nyears O\n. O\n\nThe O\nClinton B-PER\nadministration O\n's O\nstrong O\nviews O\non O\nthis O\nsubject O\nhave O\nbeen O\nconveyed O\nto O\nthe O\nGreek B-MISC\ngovernment O\n, O\nBurns B-PER\nsaid O\n. O\n\nMahammad B-PER\nRashid I-PER\nwas O\nwhisked O\nfrom O\nKorydallos B-LOC\nmaximum O\nsecurity O\nprison O\njust O\noutside O\nAthens B-LOC\nto O\nthe O\nairport O\nwhere O\nhe O\nboarded O\na O\nregular O\nOlympic B-ORG\nAirways I-ORG\nflight O\nto O\nCairo B-LOC\nwhere O\nhe O\nwould O\ntransit O\nto O\nTunis B-LOC\nand O\nthe O\nformer O\nPalestine B-ORG\nLiberation I-ORG\nOrganisation I-ORG\nheadquarters O\n. O\n\nRashid B-PER\n, O\n46 O\n, O\nwas O\nsentenced O\nto O\n18 O\nyears O\nin O\nprison O\nby O\na O\nGreek B-MISC\ncourt O\nin O\n1992 O\nafter O\nbeing O\nconvicted O\nof O\npremeditated O\nmurder O\nin O\nthe O\nmid-air O\nbombing O\nof O\na O\nPan B-MISC\nAmerican I-MISC\nairliner O\nin O\n1982 O\n. O\n\nHis O\nsentence O\nhad O\nbeen O\nreduced O\nto O\n15 O\nyears O\nin O\n1993 O\n. O\n\nA O\nparole O\ncourt O\nruled O\nrecently O\nthat O\nRashid B-PER\ncould O\nbe O\nfreed O\nafter O\nserving O\n8-1/2 O\nyears O\n, O\nwith O\ntime O\nin O\npre-trial O\ndetention O\ncounted O\ntowards O\nhis O\nterm O\n, O\nbut O\nsaid O\nhe O\nmust O\nbe O\nexpelled O\nimmediately O\nfrom O\nGreece B-LOC\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\naccuses O\nRashid B-PER\nof O\nbelonging O\nto O\nthe O\nMay O\n15 O\nPalestinian B-MISC\nguerrilla O\ngroup O\nand O\nbeing O\nan O\naccomplished O\nstudent O\nof O\nmaster O\nPalestinian B-MISC\nbombmaker O\nAbu B-PER\nIbrahim I-PER\n. O\n\nThree O\nFBI B-ORG\nagents O\nwho O\ntestified O\nagainst O\nRashid B-PER\nduring O\nthe O\ntrial O\n, O\nheld O\nat O\nKorydallos B-LOC\nprison O\n, O\nsaid O\nthey O\nhad O\nample O\nevidence O\nagainst O\nRashid B-PER\nfor O\na O\nbomb O\nplanted O\non O\na O\nPan B-MISC\nAmerican I-MISC\nplane O\nin O\nBrazil B-LOC\nin O\n1982 O\nand O\na O\nmid-air O\nbomb O\nblast O\non O\na O\nTWA B-ORG\nairliner O\napproaching O\nAthens B-LOC\nin O\n1986 O\nwhich O\nkilled O\nfour O\nU.S. B-LOC\ncitizens O\n. O\n\n-DOCSTART- O\n\nSchool O\nfootball O\nplayer O\nbanned O\nfor O\nslashing O\nopponents O\n. O\n\nALBUQUERQUE B-LOC\n, O\nN.M. B-LOC\n1996-12-05 O\n\nA O\nNew B-LOC\nMexico I-LOC\nhigh O\nschool O\nfootball O\nplayer O\nwho O\nused O\nrazor-sharp O\nhelmet O\nbuckles O\nto O\nslash O\nopponents O\nand O\na O\nreferee O\nwas O\nexpelled O\nfrom O\nhigh O\nschool O\nbanned O\nThursday O\nfrom O\ncompetition O\nfor O\none O\nyear O\n. O\n\nMike B-PER\nCito I-PER\n, O\n17 O\n, O\nwas O\nexpelled O\nfrom O\nSt B-ORG\nPius I-ORG\nX I-ORG\nHigh I-ORG\nSchool I-ORG\nin O\nAlbuquerque B-LOC\nafter O\nan O\nOctober O\ngame O\nin O\nwhich O\nhe O\nused O\nthe O\nsharpened O\nchin O\nstrap O\nbuckles O\nto O\ninjure O\ntwo O\nopposing O\nplayers O\nand O\nthe O\nreferee O\n. O\n\nOne O\nof O\nthe O\nplayers O\nneed O\n10 O\nstitches O\nto O\na O\ncut O\non O\nhis O\nforearm O\n. O\n\nOfficials O\nsaid O\nthe O\nNew B-ORG\nMexico I-ORG\nActivities I-ORG\nAssociation I-ORG\ndecided O\nto O\nbar O\nCito B-PER\nfrom O\nany O\ninter-scholastic O\ncompetition O\nuntil O\nnext O\nOctober O\n, O\nregardless O\nof O\nthe O\nschool O\nhe O\nattends O\n. O\n\nCito B-PER\n's O\nfather O\n, O\nStephen B-PER\nCito I-PER\n, O\nhad O\nadmitted O\nfiling O\nthe O\nmetal O\nbuckles O\nto O\na O\nfine O\nedge O\n, O\nsaying O\nhe O\ndid O\nit O\nto O\nget O\neven O\nwith O\nthe O\nreferee O\nand O\nwith O\nplayers O\nwho O\nhad O\nroughed O\nup O\nhis O\nson O\nin O\na O\nprevious O\ngame O\n. O\n\n-DOCSTART- O\n\nCyberspace O\nsquabbles O\novershadow O\ncopyright O\ntalks O\n. O\n\nElif B-PER\nKaban I-PER\n\nGENEVA B-LOC\n1996-12-06 O\n\nIn O\na O\ngloomy O\nGeneva B-LOC\nconference O\ncentre O\nbuilt O\nbefore O\nthe O\ndawn O\nof O\nthe O\nInternet B-MISC\n, O\ngroups O\nof O\nstaid O\nofficials O\nmade O\na O\nfirst O\nstab O\non O\nFriday O\nat O\nrewriting O\ncopyright O\nlaws O\nfor O\nthe O\ndigital O\nage O\n. O\n\nBut O\ncritics O\nat O\nthe O\nfirst O\ngovernment-level O\nmeeting O\nto O\nrevise O\ncopyright O\nlaws O\nin O\n25 O\nyears O\nsaid O\nthe O\nofficials O\nand O\nlegislators O\nmight O\nas O\nwell O\nbe O\ntrying O\nto O\npolice O\nthe O\nether O\n. O\n\nAfter O\nfour O\ndays O\nof O\ndiplomatic O\nwrangling O\nover O\nprocedures O\n, O\nsome O\n600 O\ndelegates O\nfrom O\nnations O\nsmall O\nand O\nlarge O\ngot O\ndown O\nto O\nthe O\nnitty-gritty O\nof O\nsetting O\nthe O\ndigital O\nagenda O\nfor O\nthe O\nfirst O\ntime O\n. O\n\nCyberspace O\nsquabbles O\novershadowed O\nthe O\ndebate O\non O\na O\nstack O\nof O\nproposals O\ncovering O\nliterary O\nand O\nartistic O\nworks O\n, O\nthe O\nrights O\nof O\nperformers O\nand O\nproducers O\nof O\nmusic O\nand O\nproducers O\nof O\ndatabases O\n. O\n\n\" O\nIf O\nit O\ngoes O\non O\nlike O\nthis O\n, O\nwe O\nwo O\nn't O\nhave O\nenough O\ntime O\nto O\nfinish O\nall O\nthe O\ndiscussions O\n, O\n\" O\na O\nfrustrated O\nWestern O\ndelegate O\nsaid O\n. O\n\" O\n\nThey O\nannounced O\nthey O\nwill O\nstart O\nevening O\nsessions O\nnext O\nweek O\n. O\n\" O\n\nAttempts O\nby O\ncopyright-based O\nindustries O\nto O\nensure O\nthey O\nget O\na O\ncut O\nfrom O\nonline O\nworks O\nled O\nto O\na O\nstorm O\nof O\nprotests O\nby O\nInternet B-MISC\ncompanies O\nand O\ncritics O\nwho O\nsay O\nthe O\npacts O\nwould O\ncurb O\npublic O\naccess O\nto O\nonline O\ninformation O\nfrom O\nsoccer O\nresults O\nto O\nstock O\nprices O\n. O\n\n\" O\nIt O\n's O\nnot O\nillegal O\nto O\nmake O\nphotocopies O\nof O\nnewspaper O\narticles O\n. O\n\nIt O\n's O\nfair O\nuse O\n. O\n\nWe O\ncan O\nread O\nsports O\nstatistics O\nor O\nstock O\nprices O\n. O\n\nBut O\nwith O\nthe O\ntreaty O\n, O\nthis O\nkind O\nof O\nfact O\nwill O\nbe O\nowned O\nand O\nsubject O\nto O\nlicensing O\n, O\n\" O\nsaid O\nJames B-PER\nLove I-PER\n, O\na O\nconsumer O\nlobbyist O\nheading O\nthe O\nWashington-based B-MISC\nConsumer B-PER\nProject I-PER\non O\nTechnology O\n. O\n\n\" O\nNone O\nof O\nthe O\ntreaties O\nare O\nready O\nto O\nmove O\n. O\n\nThese O\npeople O\ndo O\nn't O\nunderstand O\nwhat O\nthey O\n're O\ndoing O\n. O\n\" O\n\nAt O\nstake O\nare O\nbillions O\nof O\ndollars O\nand O\nthe O\nfuture O\nof O\nthe O\nelectronic O\ninformation O\nindustry O\n-- O\nthe O\ncoming O\nmedium O\nfor O\nthe O\ndistribution O\nof O\nmusic O\n, O\nfilms O\n, O\nliterature O\n, O\nsoftware O\nand O\ncommerce O\n. O\n\nSupporters O\nof O\nthe O\nthree O\npacts O\nsay O\nthey O\nare O\nonly O\nan O\nextension O\nof O\nexisting O\nintellectual O\nproperty O\nrights O\n, O\ncovered O\nby O\nthe O\ncentury-old O\nBerne B-MISC\nConvention I-MISC\n. O\n\nBut O\nan O\narray O\nof O\nopponents O\nfrom O\nthe O\nnetwork O\nindustry O\nto O\nconsumer O\n, O\nscientific O\nand O\nacademic O\ngroups O\nsay O\nthe O\npacts O\nwill O\ngive O\nsweeping O\npowers O\nto O\nentertainment O\nand O\ncopyright-based O\nindustries O\n. O\n\nA O\nquick O\nsurvey O\nat O\nthe O\nconference O\ncentre O\nfound O\nfew O\nofficials O\nwho O\nhad O\nactually O\nsurfed O\nthe O\nInternet B-MISC\n. O\n\nMongolia B-LOC\n's O\nstate O\ncopyright O\nofficial O\n, O\nGundegma B-PER\nJargalshaihan I-PER\n, O\nsaid O\napologetically O\nthat O\nhe O\nhad O\njust O\narrived O\nfrom O\nUlan B-LOC\nBator I-LOC\nand O\nwas O\nnot O\naware O\nof O\nthe O\ndetails O\nof O\nthe O\ndigital O\nagenda O\n. O\n\n\" O\nWe O\ndo O\nn't O\nhave O\nmoney O\nfor O\nInternet B-MISC\nin O\nMongolia B-LOC\n, O\n\" O\nhe O\nadded O\n. O\n\nAlexander B-PER\nBavykin I-PER\n, O\ndeputy O\nlegal O\nchief O\nat O\nRussia B-LOC\n's O\nforeign O\nministry O\n, O\nsaid O\nMoscow B-LOC\nhad O\nyet O\nto O\nformulate O\na O\npolicy O\non O\ncopyright O\nin O\ncybersppace O\n. O\n\nHe O\ntoo O\nhad O\nnever O\nbrowsed O\nthe O\nNet O\n. O\n\n\" O\nI O\n've O\nnever O\ntried O\nit O\nand O\nwhy O\nshould O\nI O\n? O\n\nThere O\nare O\nlots O\nof O\nother O\nthings O\nin O\nthis O\nlife O\nI O\nhave O\nn't O\ntried O\neither O\n, O\n\" O\nhe O\nsaid O\n. O\n\nA O\nvisit O\nto O\nthe O\ncomputer O\ncentre O\noffering O\nInternet B-MISC\nservices O\nfound O\na O\nlone O\nEuropean B-MISC\nofficial O\nclicking O\naway O\non O\nhis O\nmouse O\n. O\n\n\" O\nInternet B-MISC\nis O\na O\npotential O\ncash O\ncow O\nfor O\ncopyright-based O\nindustries O\nand O\nwe O\nneed O\nroadmaps O\non O\nthe O\ninformation O\nsuperhighway O\n, O\n\" O\nsaid O\nMarc B-PER\nPearl I-PER\n, O\nvice-president O\nof O\nthe O\nInformation B-ORG\nTechnology I-ORG\nAssociation I-ORG\nof I-ORG\nAmerica I-ORG\n, O\na O\ntrade O\nassociation O\nof O\nU.S. B-LOC\nnetwork O\ncompanies O\nopposing O\nthe O\ntreaties O\n. O\n\n\" O\nBut O\nthere O\nare O\na O\nlot O\nof O\ndinosaurs O\nhere O\n. O\n\nPeople O\nhere O\ndo O\nn't O\nunderstand O\nInternet B-MISC\ntechnology O\n. O\n\nBecause O\nthey O\ndo O\nn't O\nunderstand O\ntechnology O\n, O\nthey O\nfear O\nthe O\nunknown O\n. O\n\" O\n\nBefore O\nthe O\nInternet B-MISC\n, O\nthose O\nwhose O\nbusiness O\nwas O\nto O\nprotect O\ncopyrights O\nknew O\nwhere O\nthey O\nstood O\n. O\n\nTheir O\nenemies O\nwere O\ntangible O\nif O\nelusive O\n, O\nsuch O\nas O\nthe O\npeople O\nwho O\npirated O\nmusic O\ncassettes O\n. O\n\nBut O\nthe O\nInternet B-MISC\n, O\na O\nglobal O\ncomputer O\nnetwork O\nwhere O\nanything O\nfrom O\nmusic O\nto O\nsoftware O\ncan O\nbe O\nduplicated O\nand O\ndistributed O\nat O\nthe O\nclick O\nof O\na O\ncomputer O\nmouse O\n, O\nhas O\nripped O\nup O\nthe O\nrulebooks O\n. O\n\nNetwork B-MISC\noperators O\nsaid O\nthe O\ndraft O\nlaws O\nwould O\nhold O\nthem O\nresponsible O\nfor O\ncopyright O\ninfringements O\nin O\nthe O\nsystem O\nand O\nexpose O\nthem O\nto O\nmulti-billion-dollar O\nliabilities O\n. O\n\n\" O\nThere O\nare O\n500 O\nmillion O\nmessages O\ntransmitted O\nthrough O\nthe O\nInternet B-MISC\neveryday O\n, O\n\" O\nsaid O\nTim B-PER\nCasey I-PER\nof O\nthe O\nU.S.-based B-MISC\nMCI B-ORG\nCommunications I-ORG\nCorporation I-ORG\n. O\n\" O\n\nHow O\ncan O\nwe O\ncontrol O\nthem O\nall O\n? O\n\" O\n\n-DOCSTART- O\n\nItaly B-LOC\nevacuates O\n17 O\nnuns O\nand O\npriests O\nfrom O\nZaire B-LOC\n. O\n\nROME B-LOC\n1996-12-06 O\n\nItaly B-LOC\nsaid O\non O\nFriday O\nit O\nhad O\nevacuated O\n17 O\nRoman B-MISC\nCatholic I-MISC\nnuns O\nand O\npriests O\nfrom O\nZaire B-LOC\nwhere O\nthey O\nhad O\nbeen O\nat O\nrisk O\nfrom O\nfighting O\nbetween O\ngovernment O\ntroops O\nand O\nethnic O\nTutsi B-MISC\nrebels O\n. O\n\nThe O\nForeign B-ORG\nMinistry I-ORG\nsaid O\nthe O\n10 O\nEuropeans B-MISC\nand O\nseven O\nAfricans B-MISC\ntook O\na O\nspecial O\nflight O\nfrom O\nthe O\nGaramba B-LOC\nnational O\npark O\nin O\nnorthern O\nZaire B-LOC\nto O\nthe O\nUgandan B-MISC\ncapital O\nKampala B-LOC\nwhere O\nthey O\nwere O\nbeing O\nlooked O\nafter O\nat O\nthe O\nItalian B-MISC\nembassy O\n. O\n\nThe O\ngroup O\nhad O\ntravelled O\nfrom O\ntheir O\nmission O\non O\nthe O\nedge O\nof O\nthe O\npark O\nto O\na O\nlanding O\nstrip O\nto O\nmake O\nthe O\nrendezvous O\n, O\na O\nministry O\nofficial O\nsaid O\n. O\n\nThe O\nministry O\nsaid O\nthe O\ngroup O\nconsisted O\nof O\n13 O\nnuns O\n, O\nseven O\nItalians B-MISC\nand O\nsix O\nZaireans B-MISC\n, O\nand O\nfour O\npriests O\n, O\ntwo O\nfrom O\nBelgium B-LOC\n, O\none O\nfrom O\nSpain B-LOC\nand O\none O\nfrom O\nZambia B-LOC\n. O\n\n-DOCSTART- O\n\nThird O\nParis B-LOC\nblast O\nvictim O\nwas O\nMoroccan B-MISC\nstudent O\n. O\n\nPARIS B-LOC\n1996-12-06 O\n\nMoroccan B-MISC\nMohamed B-PER\nBenchaou I-PER\n, O\nthe O\nthird O\nperson O\nto O\ndie O\nafter O\na O\nbombing O\non O\na O\nParis B-LOC\ntrain O\n, O\nwas O\na O\n25-year-old O\nstudent O\nabout O\nto O\nsubmit O\na O\nmathematics O\ndoctorate O\n, O\nthe O\nMoroccan B-MISC\nembassy O\nsaid O\non O\nFriday O\n. O\n\nBenchaou B-PER\ndied O\nof O\nhis O\ninjuries O\non O\nThursday O\nnight O\n, O\ntwo O\ndays O\nafter O\nthe O\nblast O\n. O\n\nA O\nnewly-married O\nCanadian B-MISC\nwoman O\nand O\na O\nman O\nfrom O\nNew B-LOC\nCaledonia I-LOC\ndied O\ninstantly O\nin O\nthe O\nbomb O\nthat O\ninjured O\n90 O\nothers O\nin O\nthe O\nrush-hour O\ntrain O\n. O\n\nAn O\nembassy O\nspokesman O\nsaid O\nBenchaou B-PER\n, O\nthe O\nson O\nof O\na O\nMoroccan B-MISC\narmy O\ncolonel O\n, O\nhad O\nbeen O\ndue O\nto O\ntake O\nhis O\ndoctorate O\nin O\nMarch O\nand O\nhoped O\nto O\nbecome O\na O\nteacher O\n. O\n\nInvestigators O\nhave O\nsaid O\nthe O\nexplosion O\nbore O\nthe O\nhallmarks O\nof O\nAlgerian B-MISC\nMoslem B-MISC\nfundamentalists O\nwho O\nstaged O\na O\nseries O\nof O\nbombings O\nlast O\nyear O\nwhich O\nkilled O\neight O\npeople O\nand O\ninjured O\nmore O\nthan O\n160 O\n. O\n\n-DOCSTART- O\n\nItalian B-MISC\nPresident O\nurges O\nseparatists O\nto O\nturn O\nback O\n. O\n\nMANTUA O\n, O\nItaly B-LOC\n1996-12-06 O\n\nItalian B-MISC\nPresident O\nOscar B-PER\nLuigi I-PER\nScalfaro I-PER\nvisited O\nthe O\nsymbolic O\nheartland O\nof O\nthe O\nseparatist O\nNorthern B-ORG\nLeague I-ORG\non O\nFriday O\nand O\nappealed O\nto O\nits O\nsupporters O\nto O\ndrop O\ntheir O\ncampaign O\nfor O\na O\nbreakaway O\nstate O\n. O\n\nAddressing O\na O\nconvention O\non O\nItalian B-MISC\nunity O\nin O\nMantua O\n, O\nwhere O\nthe O\nparty O\nhas O\nset O\nup O\nits O\nown O\n\" O\nparliament O\nof O\nthe O\nnorth O\n\" O\n, O\nScalfaro B-PER\nmade O\na O\ndirect O\nappeal O\nto O\nwhat O\nhe O\ncalled O\n\" O\nmy O\nfriends O\nfrom O\nthe O\nLeague B-ORG\n\" O\nto O\nwork O\ninstead O\nfor O\nfederal O\nreform O\n. O\n\n\" O\nIt O\nis O\nan O\ninvitation O\n, O\na O\ncommitment O\n, O\na O\npromise O\n. O\n\nLet B-LOC\n's O\nmarch O\ntogether O\n, O\n\" O\nScalfaro B-PER\n, O\na O\nnortherner O\nhimself O\n, O\nsaid O\n. O\n\n\" O\nHelp O\nItaly B-LOC\nto O\nteach O\n, O\nto O\npropose O\na O\ncapacity O\nfor O\nstrong O\nlocal O\nautonomy O\n, O\nfor O\nthe O\nfederalism O\nwhich O\ncan O\ngive O\nnew O\nvigour O\nto O\nour O\nblood O\n. O\n\nBut O\nturn O\nback O\nfrom O\nthe O\nline O\nyou O\nare O\ntaking O\nnow O\n, O\n\" O\nhe O\nsaid O\n. O\n\nScalfaro B-PER\nwas O\nin O\nMantua B-LOC\nto O\nattend O\na O\nceremony O\ncommemorating O\nthe O\nexecutions O\nthere O\nby O\nAustrian B-MISC\nrulers O\nin O\n1852 O\nand O\n1853 O\nof O\na O\ngroup O\nof O\nItalians B-MISC\nwho O\nhad O\ncampaigned O\nfor O\nnational O\nunity O\n. O\n\nHe O\nwas O\njeered O\nand O\nwhistled O\nat O\nby O\na O\nsmall O\ngroup O\nof O\nLeague B-LOC\nsupporters O\nwhen O\nhe O\narrived O\nfor O\na O\nvisit O\nmarked O\nby O\nheavy O\nsecurity O\n. O\n\nWitnesses O\nsaid O\nthe O\nprotesters O\nwere O\noutnumbered O\nby O\nother O\nItalians B-MISC\nwho O\nwaved O\ntricolour O\nflags O\nin O\nthe O\nnational O\nred O\n, O\nwhite O\nand O\ngreen O\nor O\nshouted O\n\" O\nViva O\nItalia B-LOC\n\" O\n. O\n\nThe O\nLeague B-ORG\nwon O\nmore O\nthan O\neight O\npercent O\nof O\nvotes O\nat O\nthe O\nlast O\ngeneral O\nelection O\nin O\nApril O\non O\na O\nfederalist O\nplatform O\nbut O\nits O\nleader O\nUmberto B-PER\nBossi I-PER\nlater O\nswitched O\nto O\na O\nseparatist O\nagenda O\n. O\n\nA O\nthree-day O\n\" O\nindependence O\n\" O\nmarch O\nalong O\nthe O\nPo B-LOC\nRiver O\nin O\nSeptember O\n, O\nculminating O\nin O\na O\ndeclaration O\nin O\nVenice B-LOC\nof O\na O\nself-styled O\n\" O\nRepublic B-LOC\nof I-LOC\nPadania I-LOC\n\" O\n, O\nflopped O\nbadly O\n. O\n\n-DOCSTART- O\n\nDenmark B-LOC\n's O\nRadiometer O\nH1 O\nresult O\nseen O\nflat O\n. O\n\nCOPENHAGEN B-LOC\n1996-12-06 O\n\nA O\nReuter B-ORG\nconsensus O\nsurvey O\nsees O\nmedical O\nequipment O\ngroup O\nRadiometer B-ORG\nreporting O\nlargely O\nunchanged O\nearnings O\nwhen O\nit O\npublishes O\nfirst O\nhalf O\n19996/97 O\nresults O\nnext O\nWednesday B-ORG\n. O\n\nAn O\naverage O\nof O\nfour O\nanalysts O\n' O\nforecasts O\npredicted O\npre-tax O\nprofit O\nof O\n147.3 O\nmillion O\ncrowns O\ncompared O\nto O\n144.5 O\nmillion O\nin O\nthe O\nfirst O\nsix O\nmonths O\nof O\n1995/96 O\n. O\n\nThey O\nsaid O\nthat O\nthe O\ngroup O\n's O\nfailure O\nto O\nintroduce O\nnew O\nproducts O\nwas O\nbehind O\nthe O\nshare O\n's O\nweak O\nperformance O\nin O\n1996 O\n, O\nduring O\nwhich O\nit O\nhas O\nlost O\nseven O\npercent O\nso O\nfar O\n. O\n\n-- O\nSoeren B-PER\nLinding I-PER\nJakobsen I-PER\n, O\nCopenhagen B-LOC\nnewsroom O\n+45 O\n33969650 O\n\n-DOCSTART- O\n\nMoslem B-MISC\nfundamentalists O\nkill O\n19 O\nAlgerians B-MISC\n- O\nagency O\n. O\n\nPARIS B-LOC\n1996-12-06 O\n\nMoslem B-MISC\nfundamentalists O\nkilled O\n19 O\ncivilians O\novernight O\nin O\nBlida B-LOC\nprovince O\nsouth O\nof O\nAlgiers B-LOC\n, O\nAlgerian B-MISC\nsecurity O\nforces O\nsaid O\non O\nFriday O\n. O\n\nIn O\na O\nstatement O\ncarried O\non O\nthe O\nofficial O\nAlgerian B-MISC\nnews O\nagency O\nAPS B-ORG\n, O\nthe O\nsecurity O\nforces O\nsaid O\nthe O\n19 O\nhad O\nbeen O\nkilled O\nby O\n\" O\na O\ngroup O\nof O\nterrorists O\n\" O\n. O\n\n-DOCSTART- O\n\nBelgian B-MISC\npolice O\nsmash O\nmajor O\ndrugs O\nrings O\n, O\n30 O\narrested O\n. O\n\nBRUSSELS B-LOC\n1996-12-06 O\n\nPolice O\nsmashed O\ntwo O\ndrugs O\nsmuggling O\nrings O\nand O\narrested O\n30 O\npeople O\nafter O\na O\ntaxidriver O\nin O\nSpain B-LOC\nalerted O\nthem O\nto O\na O\nsuitcase O\nof O\nheroin O\nleft O\nin O\nhis O\ncab O\n, O\nBelgian B-MISC\npolice O\nsaid O\non O\nFriday O\n. O\n\nPolice O\nseized O\ndozens O\nof O\nkilos O\nof O\nheroin O\nwith O\na O\nstreet O\nvalue O\nof O\nhundreds O\nof O\nmillions O\nof O\nBelgian B-MISC\nfrancs O\n, O\na O\npublic O\nprosecutor O\n's O\noffice O\nspokesman O\nin O\nthe O\nport O\ncity O\nof O\nAntwerp B-ORG\nsaid O\n. O\n\nHe O\nsaid O\na O\n24-year-old O\nBelgian B-MISC\nwoman O\nleft O\na O\nsuitcase O\ncontaining O\n13 O\nkg O\n( O\n29 O\nlb O\n) O\nof O\nheroin O\nin O\na O\ntaxi O\nin O\nBarcelona B-LOC\n. O\n\nThe O\ntaxidriver O\nalerted O\npolice O\nwho O\narrested O\na O\n33-year-old O\nTurkish B-MISC\nman O\nwhen O\nhe O\ncame O\nto O\npick O\nup O\nthe O\nsuitcase O\nat O\na O\nlost O\nluggage O\noffice O\n. O\n\nThe O\nwoman O\nwas O\nlater O\narrested O\nin O\nBelgium B-LOC\n. O\n\nShe O\nand O\nthe O\nTurkish B-MISC\nman O\nsmuggled O\nheroin O\nfrom O\nTurkey B-LOC\nto O\nAntwerp B-ORG\nfrom O\nwhere O\nit O\nwas O\ntaken O\nto O\nSpain B-LOC\n, O\nFrance B-LOC\nand O\nGermany B-LOC\nby O\nothers O\n, O\nthe O\nspokesman O\nsaid O\n. O\n\nHe O\nsaid O\n14 O\npeople O\nwere O\narrested O\nin O\nBelgium B-LOC\nand O\n16 O\nothers O\nin O\nother O\nEuropean B-MISC\nnations O\nafter O\nan O\ninvestigation O\nlasting O\nnearly O\na O\nyear O\n. O\n\n( O\n$ O\n1=32.14 O\nBelgian B-MISC\nFranc O\n) O\n\n-DOCSTART- O\n\nPort O\nconditions O\nupdate O\n- O\nLloyds B-ORG\nShipping I-ORG\n. O\n\nGREECE B-LOC\n, O\nDec O\n5 O\n- O\nGreek B-MISC\nport O\nworkers O\ncalled O\noff O\na O\nstrike O\nwhich O\nhad O\nkept O\nthe O\ncountry O\n's O\nports O\nclosed O\n, O\ngiving O\nthe O\ngovernment O\nuntil O\nFeb O\n1 O\nto O\nintroduce O\na O\npromised O\nbonus O\nscheme O\n. O\n\n-DOCSTART- O\n\nGerman B-MISC\nJan-August O\ncoffee O\nimports O\ndetailed O\n. O\n\nHAMBURG B-LOC\n1996-12-06 O\n\nGerman B-MISC\nnet O\ngreen O\ncoffee O\nimports O\nfrom O\noutside O\nthe O\nEU B-ORG\ntotalled O\n7.73 O\nmillion O\nbags O\nin O\nJanuary-August O\ncompared O\nwith O\n7.66 O\nmillion O\nin O\nthe O\nyear-ago O\nperiod O\n, O\nthe O\nDKV B-ORG\ncoffee O\nassociation O\nsaid O\n. O\n\nImports O\nof O\n1.04 O\nmillion O\nbags O\nin O\nAugust O\nwere O\ndown O\nfrom O\n1.08 O\nmillion O\nin O\nAugust O\n1995 O\nbut O\nup O\nfrom O\n992,860 O\nbags O\nin O\nJuly O\n1996 O\n. O\n\nColombia B-LOC\nshipped O\n198,226 O\nbags O\nin O\nAugust O\nafter O\n164,185 O\nin O\nJuly O\n, O\nEl B-LOC\nSalvador I-LOC\n160,553 O\n( O\n129,184 O\n) O\n, O\nIndonesia B-LOC\n72,218 O\n( O\n78,959 O\n) O\n, O\nEthiopia B-LOC\n69,252 O\n( O\n60,456 O\n) O\nand O\nKenya B-LOC\n63,969 O\n( O\n60,043 O\n) O\n. O\n\nBrazil B-LOC\nwas O\nin O\nseventh O\nposition O\nwith O\n54,333 O\nbags O\n( O\n29,055 O\n) O\n. O\n\n-- O\nHamburg B-LOC\nnewsroom O\n+49-40-41903275 O\n\n-DOCSTART- O\n\nMunich B-ORG\nRe I-ORG\nsays O\nto O\nsplit O\nstock O\n. O\n\nMUNICH B-LOC\n, O\nGermany B-LOC\n1996-12-06 O\n\nMuenchener B-MISC\nRueckversicherungs B-ORG\nAG I-ORG\n, O\nthe O\nworld O\n's O\nlargest O\nreinsurer O\n, O\nsaid O\non O\nFriday O\nit O\nexpected O\nto O\nswitch O\nits O\nshares O\nto O\na O\nlower O\npar O\nvalue O\nby O\nSeptember O\n1997 O\nat O\nthe O\nearliest O\n. O\n\nThe O\ngroup O\n, O\nknown O\nas O\nMunich B-ORG\nRe I-ORG\n, O\nplans O\nto O\nseek O\napproval O\nfor O\nthe O\nmove O\nat O\nits O\nshareholders O\n' O\nmeeting O\ntoday O\n. O\n\nThe O\ncompany O\nsaid O\nthe O\nswitch O\nwould O\nprobably O\nbecome O\neffective O\nin O\nSeptember O\n. O\n\nThe O\nplanned O\n10-for-one O\nstock O\nsplit O\nwould O\nreduce O\nthe O\npar O\nvalue O\nof O\nMunich B-ORG\nRe I-ORG\n's O\nshares O\nto O\nfive O\nmarks O\nfrom O\n50 O\n, O\ncausing O\ntheir O\nprice O\nto O\ndrop O\nto O\naround O\none O\ntenth O\nof O\nthe O\npresent O\nvalue O\n. O\n\nMunich B-ORG\nRe I-ORG\n's O\nregistered O\nshares O\n, O\npart O\nof O\nthe O\nblue-chip O\nDAX B-MISC\nindex O\n, O\nwere O\ntrading O\nat O\n3,710 O\nmarks O\non O\nFriday O\n. O\n\n-- O\nFrankfurt B-ORG\nNewsroom I-ORG\n, O\n+49 O\n69 O\n756525 O\n\n-DOCSTART- O\n\nEU B-ORG\nexperts O\npostpone O\ntalks O\non O\nrice O\narea O\naid O\n. O\n\nBRUSSELS B-LOC\n1996-12-06 O\n\nEuropean B-ORG\nUnion I-ORG\nrice O\nexperts O\non O\nThursday O\npostponed O\ndiscussion O\non O\narea O\naid O\npayments O\nto O\nrice O\nproducers O\nbecause O\nthe O\ndocuments O\nwere O\nnot O\navailable O\nin O\nall O\nthe O\nEU B-ORG\nlanguages O\n, O\nan O\nEU B-ORG\noffcial O\nsaid O\non O\nFriday O\n. O\n\n\" O\nThe O\ndiscussion O\nin O\nthe O\nexperts O\ngroup O\nhad O\nto O\nbe O\npostponed O\nbecause O\nthe O\ndocuments O\nneeded O\nto O\nbe O\ntranslated O\ninto O\nthe O\nofficial O\nlanguages O\nand O\nthe O\nitem O\nwill O\nbe O\non O\nnext O\nweek O\n's O\nagenda O\n, O\n\" O\nthe O\noffcial O\nsaid O\n. O\n\nEuropean B-MISC\nrice O\nproducers O\nare O\ndue O\nto O\nget O\ncompensatory O\narea O\naid O\npayments O\nsimilar O\nto O\nthose O\npaid O\nto O\ncereal O\nproducers O\nbecause O\nof O\ncuts O\nin O\nintervention O\nprices O\n. O\n\n-- O\nBrussels B-ORG\nNewsroom I-ORG\n32 O\n2 O\n287 O\n6800 O\n\n-DOCSTART- O\n\nFrankfurt B-LOC\ndollar O\nfix O\n1.5338 O\nmarks O\n. O\n\nFRANKFURT B-LOC\n1996-12-06 O\n\nThe O\ndollar O\nwas O\nfixed O\nat O\n1.5338 O\nmarks O\nin O\nFrankfurt B-LOC\non O\nFriday O\n, O\nafter O\n1.5607 O\nmarks O\non O\nThursday O\n. O\n\nThere O\nwas O\nno O\nBundesbank B-ORG\nintervention O\n. O\n\n-DOCSTART- O\n\nJohn B-ORG\nLewis I-ORG\nUK I-ORG\nstore O\nsales O\nup O\n4.5 O\n% O\nin O\nweek O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nThe O\nJohn B-PER\nLewis I-PER\nPartnership O\nsaid O\nits O\nUK B-LOC\ndepartment O\nstore O\nsales O\nrose O\n4.5 O\npercent O\nin O\nthe O\nweek O\nto O\nNovember O\n30 O\ncompared O\nwith O\nthe O\nsame O\nweek O\na O\nyear O\nearlier O\n. O\n\nIn O\nthe O\n18 O\nweeks O\nto O\nNovember O\n30 O\n, O\nsales O\nwere O\nup O\n13.6 O\npercent O\nyear-on-year O\n. O\n\nTotal O\nsales O\n, O\nincluding O\nthe O\nWaitrose B-ORG\nsupermarket O\nchain O\n, O\nrose O\n5.8 O\npercent O\nin O\nthe O\nweek O\nand O\nwere O\nup O\n11.4 O\npercent O\nin O\nthe O\n18-week O\nperiod O\n. O\n\n-- O\nRosemary B-PER\nBennett I-PER\n, O\nLondon B-ORG\nNewsroom I-ORG\n44 O\n171 O\n542 O\n2774 O\n\n-DOCSTART- O\n\nTimah B-ORG\nat O\n15.625 O\nin O\nLondon B-LOC\nat O\n0931 O\nGMT B-MISC\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nPT B-ORG\nTambang I-ORG\nTimah I-ORG\nwas O\ntraded O\nat O\n$ O\n15.625 O\nper O\nGDR O\nin O\nLondon B-LOC\non O\nFriday O\nat O\naround O\n0931 O\nGMT B-MISC\n. O\n\nIt O\nrecorded O\na O\nlow O\nof O\n$ O\n15.625 O\nand O\na O\nhigh O\nof O\n$ O\n15.725 O\n. O\n\nIts O\nprevious O\nclose O\non O\nThursday O\nwas O\n$ O\n15.80 O\n. O\n\nOne O\nGlobal O\nDepository O\nReceipt O\nrepresents O\n10 O\ncommon O\nshares O\n. O\n\n-- O\nJakarta B-LOC\nnewsroom O\n+6221 O\n384-6364 O\n\n-DOCSTART- O\n\nBritish B-MISC\n\" O\nEuro-sceptic B-MISC\n\" O\nsays O\nClarke B-PER\nshould O\nresign O\n. O\n\nLONDON B-LOC\n1996-12-06 O\n\nA O\n\" O\nEuro-sceptic B-MISC\n\" O\nmember O\nof O\nthe O\nruling O\nConservative B-MISC\nparty O\nsaid O\non O\nThursday O\nBritish B-MISC\nfinance O\nminister O\nKenneth B-PER\nClarke I-PER\nhad O\nto O\nresign O\nto O\nprevent O\nthe O\nparty O\ndisintegrating O\nover O\nthe O\nissue O\nof O\na O\nsingle O\nEuropean B-MISC\ncurrency O\n. O\n\nMember O\nof O\nParliament O\nTony B-PER\nMarlow I-PER\nsaid O\nthe O\nresignation O\nof O\nthe O\nchancellor O\nof O\nthe O\nexchequer O\nwas O\nthe O\nonly O\nway O\nto O\nmake O\nthe O\nConservatives O\nelectable O\nin O\na O\ngeneral O\nelection O\nwhich O\nmust O\ntake O\nplace O\nby O\nMay O\nnext O\nyear O\n. O\n\n\" O\nWe O\nhave O\na O\ndivided O\nand O\nsplit O\nCabinet B-ORG\n. O\n\nThis O\ncannot O\nendure O\n, O\n\" O\nMarlow B-PER\ntold O\nBBC B-ORG\ntelevision O\n's O\nNewsnight B-MISC\nprogramme O\non O\nThursday O\n. O\n\" O\n\nIt O\nis O\nnot O\nsustainable O\n. O\n\nKenneth B-PER\nClarke I-PER\nhas O\nto O\ngo O\n. O\n\nIf O\nhe O\ndoes O\nn't O\nresign O\n, O\nthe O\nprime O\nminister O\nhas O\ngot O\nto O\nfire O\nhim O\n. O\n\" O\n\nMarlow B-PER\n's O\ncomment O\ncome O\non O\nthe O\nheels O\nof O\nspeculation O\nthat O\nClarke B-PER\nhad O\nthreatened O\nto O\nresign O\nif O\nthe O\ngovernment O\nchanged O\nits O\n\" O\nwait O\nand O\nsee O\n\" O\npolicy O\non O\na O\nsingle O\ncurrency O\nand O\ndeclared O\nit O\nwould O\nnot O\nsign O\nup O\nfor O\nthe O\ncurrency O\nin O\nthe O\nnext O\nParliament O\n. O\n\nClarke B-PER\ndenied O\non O\nThursday O\nhe O\nhad O\nthreatened O\nto O\nresign O\nand O\nsaid O\nhis O\nposition O\non O\nthe O\nsingle O\ncurrency O\nwas O\nin O\ntune O\nwith O\nthat O\nof O\nPrime O\nMinister O\nJohn B-PER\nMajor I-PER\n. O\n\nMajor B-PER\ntold O\nparliament O\non O\nThursday O\nhe O\nwould O\nkeep O\nhis O\noptions O\nopen O\non O\nsingle-currency O\nmembership O\n. O\n\nHis O\nstatement O\nwas O\ninterpreted O\nas O\na O\nsignificant O\nvictory O\nfor O\nClarke B-PER\nand O\nfellow O\npro-European B-MISC\nMichael B-PER\nHeseltine I-PER\n, O\ndeputy O\nprime O\nminister O\n. O\n\nPro-European B-MISC\nConservative B-MISC\nMP O\nEdwina B-PER\nCurrie I-PER\ntold O\nthe O\nBBC B-ORG\nthat O\nif O\nClarke B-PER\nresigned O\n, O\nother O\nministers O\nwould O\ngo O\nwith O\nhim O\n. O\n\n-DOCSTART- O\n\nCourt O\nejects O\nhead O\nof O\nAustralian B-MISC\nchild-sex O\ninquiry O\n. O\n\nCANBERRA B-LOC\n1996-12-06 O\n\nThe O\nAustralian B-MISC\nopposition O\non O\nFriday O\ndemanded O\na O\nhigh-powered O\ninvestigation O\ninto O\npaedophilia O\nin O\nthe O\nAustralian B-MISC\ndiplomatic O\nservice O\nafter O\nthe O\nfederal O\ncourt O\nforced O\nthe O\nhead O\nof O\nthe O\nexisting O\ninquiry O\nto O\nstand O\naside O\n. O\n\nThe O\ncourt O\nsaid O\ninquiry O\nhead O\nChris B-PER\nHunt I-PER\nmight O\nbe O\nbiased O\n, O\nsince O\nhe O\nprivately O\ntold O\na O\nnewspaper O\nhe O\nhad O\nturned O\nup O\nno O\nmajor O\nevidence O\nof O\npaedophile O\nactivity O\n, O\neven O\nthough O\nhe O\nstill O\nhad O\nmonths O\n' O\nof O\ninvestigation O\nbefore O\nhim O\n. O\n\n\" O\nToday O\nwe O\nare O\nleft O\nwith O\na O\nruinous O\nwreck O\nbeyond O\nsalvage O\nand O\na O\ncontinuing O\npall O\nof O\ndoubt O\nand O\nsuspicion O\nhanging O\nover O\nour O\ndiplomatic O\nservice O\n, O\n\" O\nopposition O\nforeign O\naffairs O\nspokesman O\nLaurie B-PER\nBrereton I-PER\nsaid O\n. O\n\nBut O\nthe O\ngovernment O\nresponded O\nby O\npressing O\nahead O\nwith O\nthe O\noriginal O\ninquiry O\n, O\nestablished O\nin O\nMay O\n, O\nappointing O\na O\nnew O\nhead O\nto O\nlead O\nit O\n. O\n\nCritics O\nsay O\nthat O\nif O\nthere O\nwere O\nmany O\npaedophiles O\nin O\nsenior O\nposts O\nin O\nthe O\nForeign B-ORG\nAffairs I-ORG\nDepartment I-ORG\nthen O\na O\nsecret O\ninquiry O\nwould O\nbe O\nopen O\nto O\ninternal O\ninfluence O\nand O\nwould O\nbecome O\na O\npublic O\nservice O\nwhitewash O\n. O\n\nAccordingly O\n, O\nthey O\ndemand O\nan O\nopen O\ninvestigation O\n. O\n\nA O\nspokesman O\nfor O\nForeign B-ORG\nAffairs I-ORG\nMinister O\nAlexander B-PER\nDowner I-PER\nsaid O\nthe O\nappointment O\nof O\na O\nnew O\ninquiry O\nhead O\n, O\nadministrative O\nlaw O\nexpert O\nPamela B-PER\nO'Neil I-PER\n, O\nshowed O\nthe O\ngovernment O\n's O\ncommitment O\nto O\npursue O\nthe O\nmatter O\n. O\n\nA O\nreport O\nis O\ndue O\nin O\nMay O\nnext O\nyear O\n. O\n\nOne O\nAustralian B-MISC\ndiplomat O\nhas O\nbeen O\nprosecuted O\nthis O\nyear O\nfor O\nhaving O\nsex O\nwith O\na O\nCambodian B-MISC\nboy O\nunder O\n16 O\nbut O\nwas O\nacquitted O\n. O\n\nPolice O\nhave O\ninvestigated O\nothers O\n. O\n\nA O\nnewspaper O\nreported O\nallegations O\nin O\nApril O\nthat O\ndiplomats O\nhad O\ndirected O\nAustralian B-MISC\ngovernment O\naid O\nto O\ncertain O\nforeign O\norphanages O\nto O\nsecure O\nsex O\nwith O\nchildren O\n. O\n\n-DOCSTART- O\n\nAustralian B-MISC\nhitman O\nkilled O\nwrong O\nvictim O\n. O\n\nSYDNEY B-LOC\n1996-12-06 O\n\nAn O\nAustralian B-MISC\nhitman O\nwho O\nwent O\nto O\nthe O\nwrong O\nhouse O\nand O\nkilled O\nthe O\nwrong O\nman O\nwas O\nsentenced O\nto O\n20 O\nyears O\njail O\non O\nFriday O\n. O\n\nPaul B-PER\nCrofts I-PER\n, O\n33 O\n, O\nand O\nan O\naccomplice O\nwere O\ncontracted O\nto O\nshoot O\na O\nman O\n, O\nidentified O\nonly O\nas O\nTony B-PER\n, O\nin O\nthe O\nleg O\nto O\npunish O\nhim O\nfor O\nhis O\nmisconduct O\nwith O\na O\nfemale O\nfriend O\nof O\nthe O\ncontractor O\n, O\nthe O\nNew B-ORG\nSouth I-ORG\nWales I-ORG\nSupreme I-ORG\nCourt I-ORG\nwas O\ntold O\n. O\n\nBut O\nin O\nFebruary O\n1993 O\nLeszic B-PER\nBetcher I-PER\n, O\nwas O\nshot O\nand O\nkilled O\nafter O\nanswering O\na O\nknock O\nat O\nthe O\ndoor O\nof O\nhis O\nSydney B-LOC\nhome O\n. O\n\" O\n\nThe O\ninference O\nfrom O\nall O\nthe O\nmaterial O\nis O\nthat O\nthe O\nmarauders O\nhad O\ncome O\nto O\nthe O\nwrong O\nhouse O\n, O\n\" O\nJudge O\nMichael B-PER\nGrove I-PER\nsaid O\n. O\n\nIn O\nsentencing O\nCrofts B-PER\n, O\nwho O\npleaded O\nguilty O\n, O\nGrove B-PER\ntook O\ninto O\naccount O\nhis O\n\" O\nmildly O\nretarded O\n\" O\nintellectual O\nstate O\n, O\nwhich O\nplaced O\nhim O\nin O\nthe O\nlowest O\ntwo O\npercent O\nof O\nthe O\npopulation O\n. O\n\nGrove B-PER\nsaid O\nBetcher B-PER\nwas O\n\" O\nnot O\nonly O\nthe O\nvictim O\nof O\na O\nhorrendous O\ncrime O\n, O\nbut O\nhis O\ndeath O\nwas O\nbrought O\nabout O\nin O\ncircumstances O\nof O\nan O\nequally O\nghastly O\nerror O\non O\nthe O\npart O\nof O\nthe O\nprisoner O\nand O\nhis O\naccomplices O\n\" O\n. O\n\nThe O\nunnamed O\naccomplice O\nwas O\nearlier O\nsentenced O\nto O\n20 O\nyears O\nin O\nprison O\n. O\n\n-DOCSTART- O\n\nNZ B-LOC\n's O\nBolger B-PER\nsays O\nNats B-PER\nto O\nmeet O\nNZ B-LOC\nFirst O\non O\nSunday O\n. O\n\nWELLINGTON B-LOC\n1996-12-06 O\n\nNew B-LOC\nZealand I-LOC\nPrime O\nMinister O\nJim B-PER\nBolger I-PER\n, O\nemerging O\nfrom O\ncoalition O\ntalks O\nwith O\nthe O\nnationalist O\nNew B-ORG\nZealand I-ORG\nFirst I-ORG\nparty O\non O\nFriday O\nafternoon O\n, O\nsaid O\nNational B-ORG\nand O\nNZ B-ORG\nFirst I-ORG\nwould O\nmeet O\nagain O\non O\nSunday O\n. O\n\nBolger B-PER\nsaid O\nhe O\nexpected O\na O\ngovernment O\nto O\nbe O\nformed O\nby O\nThursday O\n. O\n\n-DOCSTART- O\n\nNZ B-LOC\n's O\nPeters B-PER\nsays O\nNat B-PER\n, O\nLab B-PER\ntalks O\nat O\nsimilar O\nstage O\n. O\n\nWELLINGTON B-LOC\n1996-12-06 O\n\nNew B-ORG\nZealand I-ORG\nFirst I-ORG\nleader O\nWinston B-PER\nPeters I-PER\non O\nFriday O\nsaid O\ncoalition O\ntalks O\nwith O\nthe O\nNational B-ORG\nand O\nLabour B-ORG\nparties O\nwere O\nat O\na O\nsimilar O\nlevel O\nof O\ncompletion O\n. O\n\nPeters B-PER\nleft O\na O\nmeeting O\nbetween O\nNZ B-ORG\nFirst I-ORG\nand O\nNational B-ORG\nnegotiators O\nto O\nspend O\n20 O\nminutes O\nspeaking O\nto O\nLabour B-ORG\nleader O\nHelen B-PER\nClark I-PER\n. O\n\nHe O\ntold O\nReuters B-ORG\nhe O\nhad O\nneeded O\nto O\nspeak O\nto O\nher O\nbefore O\nshe O\nleft O\nWellington B-LOC\nlater O\non O\nFriday O\n. O\n\nPeters B-PER\nsaid O\nthe O\ntalks O\nwith O\nLabour B-ORG\nand O\nNational B-ORG\nhad O\nreached O\n\" O\nabout O\nthe O\nsame O\nlevel O\nof O\ncompletion O\n, O\nand O\nthat O\n's O\ngood O\n\" O\n. O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nAustralian B-MISC\nMP O\nJohn B-PER\nLangmore I-PER\nformally O\nresigns O\n. O\n\nCANBERRA B-LOC\n1996-12-06 O\n\nAustralian B-MISC\nparliamentarian O\nJohn B-PER\nLangmore I-PER\nhas O\nformally O\nresigned O\nfrom O\nhis O\nlower O\nhouse O\nseat O\n, O\nthe O\noffice O\nof O\nHouse B-ORG\nof I-ORG\nRepresentatives I-ORG\nspeaker O\nBob B-PER\nHalverson I-PER\nsaid O\non O\nFriday O\n. O\n\n\" O\nHalverson B-PER\nannounced O\nthat O\nhe O\nhad O\nreceived O\ntoday O\nfrom O\nMr O\nJohn B-PER\nVance I-PER\nLangmore I-PER\n, O\na O\nletter O\nresigning O\nhis O\nplace O\nas O\nmember O\nof O\nthe O\nHouse B-ORG\nof I-ORG\nRepresentatives I-ORG\nfor O\nthe O\nelectoral O\ndivision O\nof O\nFraser B-PER\nin O\nthe O\nAustralian B-MISC\nCapital I-MISC\nTerritory I-MISC\n, O\n\" O\nhis O\noffice O\nsaid O\nin O\na O\nstatement O\n. O\n\nHalverson B-PER\nwas O\nconsidering O\npossible O\ndates O\nfor O\nthe O\nby-election O\n, O\nhis O\noffice O\nsaid O\n. O\n\nLangmore B-PER\n, O\n57 O\n, O\nannounced O\nin O\nNovember O\nthat O\nhe O\nintended O\nto O\nresign O\nfrom O\nparliament O\nto O\ntake O\nup O\na O\nposition O\nas O\nAustralia B-LOC\n's O\nsenior O\nrepresentative O\nat O\nthe O\nUnited B-ORG\nNations I-ORG\nheadquarters O\nin O\nNew B-LOC\nYork I-LOC\n. O\n\nHe O\nplayed O\nan O\nactive O\nrole O\nat O\nthe O\nU.N. B-ORG\nsocial O\ndevelopment O\nconference O\nin O\nCopenhagen B-LOC\nlast O\nyear O\nand O\nhas O\nco-authored O\narticles O\nwith O\nU.N. B-ORG\ndevelopment O\nprogramme O\nofficer O\nInge B-PER\nKaul I-PER\n. O\n\nLangmore B-PER\n, O\na O\npersistent O\ncampaigner O\nfor O\ninterventionist O\neconomic O\npolicy O\n, O\nhas O\nbeen O\nLabor O\nmember O\nfor O\nFraser B-PER\nsince O\n1984 O\n. O\n\nHe O\nwas O\nsenior O\nprivate O\nsecretary O\nto O\nthe O\nemployment O\nand O\nindustrial O\nrelations O\nminister O\nfrom O\n1983 O\nto O\n1984 O\nand O\nwas O\neconomic O\nadvisor O\nto O\nthen O\ntreasurer O\nPaul B-PER\nKeating I-PER\nin O\n1983 O\n. O\n\nHis O\nprevious O\nposts O\ninclude O\nassistant O\ndirector O\nof O\nthe O\nnational O\nplanning O\noffice O\nof O\nPapua B-LOC\nNew I-LOC\nGuinea I-LOC\nfrom O\n1969 O\nto O\n1973 O\n. O\n\n-- O\nCanberra B-LOC\nBureau O\n61-6 O\n273-2730 O\n\n-DOCSTART- O\n\nBurmese B-MISC\nstudents O\nmarch O\nout O\nof O\ncampus O\nagain O\n. O\n\nRANGOON B-LOC\n1996-12-06 O\n\nA O\ngroup O\nof O\nBurmese B-MISC\nstudents O\non O\nFriday O\nmarched O\nout O\nof O\nthe O\nYangon B-ORG\nInstitute I-ORG\nof I-ORG\nTechnology I-ORG\n( O\nYIT B-ORG\n) O\nin O\nthe O\nnorthern O\noutskirts O\nof O\nRangoon B-LOC\nand O\nmoved O\ntoward O\nthe O\nUniversity B-ORG\nof I-ORG\nYangon I-ORG\nabout O\nsix O\nkm O\n( O\nfour O\nmiles O\n) O\naway O\n, O\nwitnesses O\nsaid O\n. O\n\nThe O\nwitnesses O\ncould O\nnot O\ngive O\nexact O\nnumbers O\nof O\nthose O\ntaking O\npart O\nin O\nthe O\nmarch O\nor O\nany O\nother O\ndetails O\nimmediately O\n. O\n\nOn O\nMonday O\nand O\nTuesday O\n, O\nstudents O\nfrom O\nthe O\nYIT B-ORG\nand O\nthe O\nuniversity O\nlaunched O\nstreet O\nprotests O\nagainst O\nwhat O\nthey O\ncalled O\nunfair O\nhandling O\nby O\npolice O\nof O\na O\nbrawl O\nbetween O\nsome O\nof O\ntheir O\ncolleagues O\nand O\nrestaurant O\nowners O\nin O\nOctober O\n. O\n\nThe O\nprotests O\nculminated O\nat O\ndawn O\non O\nTuesday O\nwith O\nseveral O\nhundred O\nof O\nthe O\nstudent O\nprotesters O\nbeing O\ndetained O\nbriefly O\nby O\npolice O\nnear O\nthe O\ncentral O\nShwe B-LOC\nDagon I-LOC\npagoda O\nin O\nRangoon B-LOC\n. O\n\nThey O\nwere O\nlater O\nreleased O\n. O\n\nOn O\nFriday O\n, O\nsome O\nstudents O\ntold O\nReuters B-ORG\nthat O\nthey O\nwere O\nstill O\ndissatisfied O\nwith O\nthe O\nruling O\nState B-ORG\nLaw I-ORG\nand I-ORG\nOrder I-ORG\nRestoration I-ORG\nCouncil I-ORG\n's O\n( O\nSLORC B-ORG\n) O\nhandling O\nof O\ntheir O\ndemands O\n. O\n\nThey O\nsaid O\nthey O\nwanted O\nto O\norganise O\nindependent O\nunions O\non O\nuniversity O\ncampuses O\nand O\ndemanded O\nthat O\ndetails O\nof O\nthe O\npunishment O\nof O\npolicemen O\nwho O\nallegedly O\nmanhandled O\nsome O\nstudents O\nat O\nthe O\nOctober O\nbrawl O\nbe O\npublished O\nin O\nnewspapers O\n. O\n\n-DOCSTART- O\n\nThai B-MISC\nrice O\nvessels O\nloading O\nand O\nmovements O\nat O\nDec O\n06 O\n. O\n\nBANGKOK B-LOC\n1996-11-29 O\n\nThe O\nThai B-MISC\nCommerce B-ORG\nMinistry I-ORG\ndetailed O\nrice O\nloading O\nat O\nThai B-MISC\nports O\nas O\nfollows O\n( O\nin O\ntonnes O\n) O\n: O\n\nVessel O\nDate O\nof O\nArrival O\nQuantity O\nDestination O\n\nIran B-MISC\nSabr I-MISC\n19/11/96 O\n9,000 O\nIran B-LOC\n\nPrincess B-MISC\nof I-MISC\nLoine I-MISC\n19/11/96 O\n10,000 O\nPhilippines B-LOC\n\nDeligst B-MISC\n20/11/96 O\n5,500 O\nIndonesia B-LOC\n\nSeagramd B-MISC\nace O\n20/11/96 O\n5,000 O\nJapan B-LOC\n\nLucky B-MISC\nEmdldm I-MISC\n20/11/96 O\n5,000 O\nJapan B-LOC\n\nAlgoa B-MISC\nDay I-MISC\n21/11/96 O\n6,000 O\nAfrica B-LOC\n\nSangthai B-MISC\nGlory I-MISC\n22/11/96 O\n3,000 O\nSingapore B-LOC\n\nMyos B-MISC\nYang I-MISC\n5 O\n22/11/96 O\n4,000 O\nIndonesia B-LOC\n\nBudisuryana B-MISC\n22/11/96 O\n3,800 O\nMalaysia B-LOC\n\nKing B-MISC\nAce I-MISC\n22/11/96 O\n5,000 O\nJapan B-LOC\n\nTong B-MISC\nShun I-MISC\n25/11/96 O\n3,000 O\nVietnam B-LOC\n\nBut B-MISC\n2 O\n27/11/96 O\n5,000 O\nBurma B-LOC\n\n-- O\nBangkok B-MISC\nnewsroom O\n( O\n662 O\n) O\n652-0642 O\n\n-DOCSTART- O\n\nChinese B-MISC\ngirl O\nnearly O\ndies O\nfrom O\ncigarette O\nsmoke O\n. O\n\nSHANGHAI B-LOC\n1996-12-06 O\n\nA O\nfive-year-old O\ngirl O\nin O\nthe O\neast O\nChina B-LOC\ncity O\nof O\nTianjin B-LOC\nchoked O\nand O\nalmost O\ndied O\nfrom O\ncigarette O\nsmoke O\nat O\nher O\ngrandfather O\n's O\nbirthday O\nwith O\nrelatives O\nsmoking O\nfor O\nhours O\nin O\na O\nsmall O\nroom O\n, O\nthe O\nWen B-ORG\nHui I-ORG\nBao I-ORG\nnewspaper O\nsaid O\non O\nFriday O\n. O\n\nThe O\nnewspaper O\nsaid O\nthe O\ngirl O\nwas O\nrushed O\nto O\nhospital O\nand O\nfound O\nto O\nbe O\nhaving O\nextreme O\ndifficulty O\nbreathing O\n. O\n\nIt O\nsaid O\neight O\nof O\nthe O\npeople O\nat O\nthe O\nparty O\n, O\nincluding O\nthe O\ngirl O\n's O\nfather O\n, O\nimmediately O\nannounced O\nthey O\nwould O\ngive O\nup O\nsmoking O\n. O\n\n-DOCSTART- O\n\nSouth B-MISC\nKorean I-MISC\nwon O\ncloses O\ndown O\non O\nimport O\nsettlements O\n. O\n\nSEOUL B-LOC\n1996-12-06 O\n\nThe O\nwon O\nslid O\nagainst O\nthe O\nU.S. B-LOC\nunit O\non O\nFriday O\nas O\nplayers O\nprepared O\nfor O\nMonday O\n's O\nimport O\nsettlement O\nneeds O\n, O\ntraders O\nsaid O\n. O\n\nThe O\nwon O\nended O\nat O\n831.00 O\n, O\nslightly O\ndown O\nfrom O\nan O\nopening O\nof O\n830.60 O\n. O\n\nIt O\nranged O\nbetween O\n830.20 O\nand O\n831.40 O\n. O\n\n\" O\nA O\nsale O\nof O\nabout O\n$ O\n60 O\nmillion O\nby O\nHyundai B-ORG\nHeavy I-ORG\npushed O\nthe O\ndollar O\ndown O\nearlier O\nin O\nthe O\nday O\n, O\nbut O\nMonday O\n's O\nimport O\nneeds O\nhelped O\nit O\nrecover O\n, O\n\" O\nsaid O\na O\nKoram B-ORG\nBank I-ORG\ndealer O\n. O\n\nDealers O\nsaid O\nthe O\ndollar O\n/ O\nyen O\n's O\nmovement O\non O\nthe O\nworld O\nmarket O\nwould O\ncontinue O\nto O\nset O\nthe O\ntrend O\nfor O\nthe O\ndollar O\n/ O\nwon O\nnext O\nweek O\n. O\n\n-DOCSTART- O\n\nForeign O\nplanes O\nto O\nland O\nin O\nChina B-LOC\n's O\npopular O\nGuilin B-LOC\n. O\n\nBEIJING B-LOC\n1996-12-06 O\n\nChina B-LOC\n's O\ntourist O\nspot O\nof O\nGuilin B-LOC\nin O\nthe O\nsouthern O\nregion O\nof O\nGuangxi B-LOC\nwill O\nopen O\nits O\nairport O\nto O\nforeign O\naircraft O\n, O\nthe O\nXinhua B-ORG\nnews O\nagency O\nsaid O\non O\nFriday O\n. O\n\nAn O\nassessment O\ngroup O\nmade O\nup O\nof O\nthe O\nState B-ORG\nCouncil I-ORG\n's O\nPort O\nOffice O\n, O\nthe O\nCivil B-ORG\nAviation I-ORG\nAdministration I-ORG\nof I-ORG\nChina I-ORG\n, O\nthe O\nGeneral B-ORG\nAdministration I-ORG\nof I-ORG\nCustoms I-ORG\nand O\nother O\nauthorities O\nhad O\ngranted O\nthe O\nairport O\npermission O\nto O\nhandle O\nforeign O\naircraft O\n, O\nXinhua B-ORG\nsaid O\n. O\n\n\" O\nThe O\nmove O\nis O\nexpected O\nto O\ngive O\na O\nshot O\nin O\nthe O\narm O\nto O\nthe O\neconomic O\nexpansion O\nof O\nGuangxi B-LOC\nand O\nsouthwest O\nChina B-LOC\nas O\na O\nwhole O\n, O\n\" O\nthe O\nagency O\nsaid O\nbut O\ngave O\nno O\nfurther O\ndetails O\n. O\n\nGuilin B-LOC\nis O\nwell O\nknown O\nfor O\nits O\nmountain O\nand O\nriver O\nscenery O\nand O\nis O\none O\nof O\nChina B-LOC\n's O\nmost O\npopular O\ntourist O\ndestinations O\n. O\n\n-DOCSTART- O\n\nEPA B-ORG\nsays O\neconomic O\nassessment O\nunchanged O\nby O\nGDP O\ndata O\n. O\n\nTOKYO B-LOC\n1996-12-06 O\n\nJapan B-LOC\n's O\nEconomic B-ORG\nPlanning I-ORG\nAgency I-ORG\nhas O\nnot O\nchanged O\nits O\nview O\nthat O\nthe O\neconomy O\nis O\ngradually O\nrecovering O\n, O\ndespite O\nrelatively O\nweak O\ngross O\ndomestic O\nproduct O\nfigures O\nreleased O\non O\nTuesday O\n, O\nEPA B-ORG\nVice O\nMinister O\nShimpei B-PER\nNukaya I-PER\ntold O\nreporters O\non O\nFriday O\n. O\n\nHe O\nsaid O\nthe O\nGDP O\ngrowth O\nwas O\nweak O\nbut O\nthat O\nthis O\nreflected O\nthe O\neconomy O\nbetween O\nJuly O\nand O\nSeptember O\nand O\ndid O\nnot O\ntake O\ninto O\naccount O\nmore O\nrecent O\ndata O\n. O\n\nWhen O\nasked O\nabout O\nthe O\noutlook O\nfor O\nthe O\nfiscal O\nyear O\nbeginning O\nin O\nApril O\n, O\nNukaya B-PER\nsaid O\nthe O\neconomy O\nmay O\nslow O\ndown O\nin O\nthe O\nearly O\npart O\nof O\nthe O\nfiscal O\nyear O\ndue O\nto O\na O\nplanned O\nconsumption O\ntax O\nhike O\n, O\nbut O\nthat O\nwould O\nbe O\nonly O\ntemporary O\n. O\n\nThe O\nconsumption O\ntax O\nwill O\nbe O\nraised O\nto O\nfive O\npercent O\nfrom O\nthree O\npercent O\nfrom O\nApril O\n1 O\n. O\n\n-DOCSTART- O\n\nSangetsu B-ORG\n- O\n96/97 O\nparent O\nforecast O\n. O\n\nTOKYO B-LOC\n1996-12-06 O\n\nYear O\nto O\nMarch O\n31 O\n, O\n1997 O\n\n( O\nin O\nbillions O\nof O\nyen O\nunless O\nspecified O\n) O\n\nLATEST O\nACTUAL O\n\n( O\nParent O\n) O\nFORECAST O\nYEAR-AGO O\n\nSales O\n128.00 O\n117.56 O\n\nCurrent O\n12.00 O\n9.94 O\n\nNet O\n6.20 O\n5.36 O\n\nEPS O\n143.56 O\nyen O\n127.64 O\nyen O\n\nOrd O\ndiv O\n30.00 O\nyen O\n30.00 O\nyen O\n\nNOTE O\n- O\nSangetsu B-ORG\nCo I-ORG\nLtd I-ORG\nis O\na O\ntrader O\nspecialising O\nin O\ninteriors O\n. O\n\n-DOCSTART- O\n\nBre-X B-ORG\n, O\nBarrick B-ORG\nsaid O\nto O\ncontinue O\nBusang B-LOC\ntalks O\n. O\n\nK.T. B-LOC\nArasu I-LOC\n\nJAKARTA B-LOC\n1996-12-06 O\n\nCanada B-LOC\n's O\nBre-X B-ORG\nMinerals I-ORG\nLtd I-ORG\nand O\nBarrick B-ORG\nGold I-ORG\nCorp I-ORG\nare O\nto O\ncontinue O\nnegotiations O\nto O\nhammer O\nout O\na O\npartnership O\nagreement O\nto O\ndevelop O\nthe O\nspectacular O\nBusang B-LOC\ngold O\nfind O\nin O\nIndonesia B-LOC\n, O\nsources O\nclose O\nto O\nthe O\ntalks O\nsaid O\non O\nFriday O\n. O\n\n\" O\nThe O\nnegotiations O\nwill O\nbe O\nheld O\nboth O\nin O\nToronto B-LOC\nand O\nin O\nJakarta B-LOC\n, O\n\" O\none O\nsource O\n, O\nspeaking O\non O\ncondition O\nof O\nanonymity O\n, O\ntold O\nReuters B-ORG\n. O\n\nAnother O\nsource O\nsaid O\nmost O\nof O\nthe O\nkey O\nnegotiators O\nfrom O\nboth O\nBre-X B-ORG\nand O\nBarrick B-ORG\nhad O\nreturned O\nto O\nToronto B-LOC\n, O\nbut O\ndeclined O\nto O\nsay O\nif O\nthere O\nhad O\nbeen O\nany O\nprogress O\nin O\ntheir O\nnegotiations O\n. O\n\nBoth O\nsources O\nsaid O\nBre-X B-ORG\nand O\nBarrick B-ORG\ndid O\nnot O\nhold O\ntalks O\non O\nThursday O\nwith O\nMines B-ORG\nand I-ORG\nEnergy I-ORG\nMinistry I-ORG\nSecretary-General O\nUmar B-PER\nSaid I-PER\n, O\nwho O\nis O\ncoordinating O\nthe O\nnegotiations O\nover O\nthe O\nBusang B-LOC\nfind O\nin O\nEast B-LOC\nKalimantan I-LOC\n. O\n\nThe O\nfirst O\nsource O\nalso O\nsaid O\nBre-X B-ORG\nhad O\nuntil O\nDecember O\n21 O\nto O\nsubmit O\nto O\nthe O\nIndonesian B-ORG\nMines I-ORG\nand I-ORG\nEnergy I-ORG\nMinistry I-ORG\na O\nfeasibility O\nstudy O\non O\nthe O\ncentral O\nregion O\nof O\nthe O\nBusang B-LOC\nproperty O\n, O\nestimated O\nto O\ncontain O\n2.6 O\nmillion O\nounces O\nof O\ngold O\n. O\n\nThe O\nrichest O\nparts O\nof O\nthe O\nproperty O\nto O\nthe O\nnorth O\nand O\nsouth O\nof O\nthe O\ncentral O\nregion O\nhave O\nbeen O\nestimated O\nby O\nBre-X B-ORG\nto O\ncontain O\n57 O\nmillion O\nounces O\nof O\ngold O\n. O\n\n\" O\nBre-X B-ORG\nis O\nexpected O\nto O\ncomplete O\nthe O\nfeasibility O\nreport O\nby O\nDecember O\n16 O\nand O\nsubmit O\nit O\nto O\nthe O\ngovernment O\nbefore O\nthe O\nDecember O\n21 O\ndeadline O\n, O\n\" O\nthe O\nsource O\nsaid O\n. O\n\nHe O\nsaid O\nBre-X B-ORG\nwould O\nthen O\nformally O\nseek O\nthe O\npermission O\nof O\nthe O\nIndonesian B-MISC\ngovernment O\nto O\nbegin O\nconstruction O\nto O\ndevelop O\nBusang B-LOC\n's O\ncentral O\nregion O\n, O\nwhich O\nmight O\ntake O\nup O\nto O\ntwo O\nyears O\n. O\n\nThe O\nsource O\ndeclined O\nto O\nsay O\nif O\nthere O\nhad O\nbeen O\nany O\nprogress O\nin O\nthe O\ntalks O\nbetween O\nBre-X B-ORG\nand O\nBarrick B-ORG\n. O\n\n\" O\nThis O\nis O\na O\nhuge O\nproject O\n... O\n\nwe O\nare O\nnot O\nselling O\nfurniture O\n, O\nand O\nBre-X B-ORG\nhas O\n13,000 O\nshareholders O\nto O\nanswer O\nto O\n, O\n\" O\nthe O\nsource O\nsaid O\n. O\n\n\" O\nWhile O\nthere O\nhas O\nbeen O\nsome O\nagreement O\nin O\nprinciple O\non O\nsome O\nissues O\n, O\nthere O\nare O\nstill O\nothers O\nsuch O\nas O\nprocedures O\nand O\nmechanisms O\nthat O\nneeded O\nto O\nbe O\nsorted O\nout O\n, O\n\" O\nhe O\nadded O\n. O\n\nThe O\nsource O\nsaid O\nno O\nnew O\ndeadline O\nhad O\nbeen O\nset O\nby O\nthe O\nMines B-ORG\nand I-ORG\nEnergy I-ORG\nMinistry I-ORG\nfor O\nBre-X B-ORG\nand O\nBarrick B-ORG\nto O\nstrike O\na O\ndeal O\n. O\n\nThe O\nMinistry O\nhad O\ngiven O\nthe O\ncompanies O\nuntil O\nDecember O\n4 O\nto O\ncomplete O\na O\npartnership O\ndeal O\n, O\nand O\nadvised O\nBre-X B-ORG\nto O\ntake O\na O\n25 O\npercent O\nstake O\nand O\nBarrick B-ORG\n75 O\npercent O\nto O\ndevelop O\nthe O\nproperty O\n. O\n\n\" O\nAs O\nfar O\nas O\nI O\nam O\naware O\n, O\nthere O\n's O\nbeen O\nno O\nnew O\ndeadline O\n, O\n\" O\nthe O\nsource O\nsaid O\n. O\n\nThe O\nMinistry O\n's O\nUmar B-PER\nsaid O\non O\nThursday O\nthat O\nboth O\nBre-X B-ORG\nand O\nBarrick B-ORG\nhad O\nresponded O\npositively O\nto O\na O\ngovernment O\nletter O\nrecommending O\na O\n25-75 O\nsplit O\nin O\nthe O\nBusang B-ORG\ngold O\nproperty O\n. O\n\nThe O\ngovernment O\nalso O\nwants O\n10 O\npercent O\nof O\nthe O\nproperty O\n. O\n\nUmar B-PER\nsaid O\nthe O\ngovernment O\nhad O\nyet O\nto O\nreceive O\na O\nformal O\nreply O\nfrom O\nthe O\ncompanies O\n. O\n\nHe O\nhad O\nsaid O\nearlier O\nthat O\nif O\nthe O\ntwo O\ncompanies O\nfailed O\nto O\nreach O\na O\npartnership O\nagreement O\n, O\nthe O\ngovernment O\nwould O\nexplore O\nother O\nways O\nto O\nexpedite O\ndevelopment O\nof O\nthe O\nBusang B-ORG\nfind O\n. O\n\nBre-X B-ORG\nhas O\na O\npartnership O\ndeal O\nwith O\nPT B-PER\nPanutan I-PER\nDuta I-PER\nof O\nthe O\nPanutan B-ORG\nGroup I-ORG\nrun O\nby O\nPresident O\nSuharto B-PER\n's O\neldest O\nson O\n, O\nSigit B-PER\nHarjojudanto I-PER\n, O\nunder O\nwhich O\nPanutan B-PER\nwould O\nreceive O\n$ O\n40 O\nmillion O\nover O\n40 O\nmonths O\nplus O\na O\n10 O\npercent O\nstake O\nBusang B-ORG\n's O\nrichest O\nparts O\n. O\n\nBarrick B-ORG\nhas O\nteamed O\nup O\nwith O\na O\nconstruction O\ncompany O\nin O\nthe O\nCitra B-ORG\nGroup I-ORG\nof O\nSuharto B-PER\n's O\neldest O\ndaughter O\n, O\nSiti B-PER\nHardianti I-PER\nRukmana I-PER\n, O\nin O\nwhat O\nBarrick B-ORG\nhad O\nsaid O\nwas O\na O\npartnership O\n\" O\nto O\nprepare O\nus O\nfor O\na O\npotential O\nmining O\ndevelopment O\nproject O\n\" O\n. O\n\n-DOCSTART- O\n\nHonda B-MISC\nRV I-MISC\nexceeds O\nsales O\ntarget O\n. O\n\nTOKYO B-LOC\n1996-12-06 O\n\nHonda B-ORG\nMotor I-ORG\nCo I-ORG\nLtd I-ORG\nsaid O\non O\nFriday O\nthat O\nit O\nhad O\nreceived O\n15,000 O\ndomestic O\norders O\nfor O\nits O\nS-MX B-MISC\nrecreational O\nvehicle O\nin O\nthe O\nfirst O\ntwo O\nweeks O\nafter O\nits O\nlaunch O\n. O\n\nHonda B-ORG\nlaunched O\nthe O\nS-MX B-MISC\nlight O\nminivan O\n, O\nfeaturing O\ncubic O\nbody O\nstyling O\n, O\non O\nNovember O\n22 O\nwith O\na O\nmonthly O\nsales O\ntarget O\nof O\n5,000 O\nunits O\n. O\n\nA O\nversion O\nwith O\nlower O\nroad O\nclearance O\nand O\nfront O\nand O\nrear O\nspoilers O\naccounted O\nfor O\ntwo-thirds O\nof O\nthe O\nsales O\n. O\n\n-DOCSTART- O\n\nFEATURE O\n- O\nSingapore B-LOC\nsees O\nprestige O\nin O\nhosting O\nWTO B-ORG\n. O\n\nRamthan B-PER\nHussain I-PER\n\nSINGAPORE B-LOC\n1996-12-06 O\n\nSingapore B-LOC\n's O\nwinning O\ncampaign O\nto O\nhost O\nthe O\nWorld B-ORG\nTrade I-ORG\nOrganisation I-ORG\n( O\nWTO B-ORG\n) O\n's O\nfirst O\nministerial O\nmeeting O\nreflected O\nits O\nambition O\nto O\nplay O\na O\nkey O\nrole O\nin O\nshaping O\nglobal O\nfree O\ntrade O\n, O\nthe O\nlifeblood O\nof O\nits O\neconomy O\n, O\nanalysts O\nsaid O\n. O\n\n\" O\nAs O\none O\nof O\nthe O\nworld O\n's O\nmost O\nexternally O\noriented O\neconomies O\n, O\nSingapore B-LOC\nhas O\na O\ndisproportionately O\nlarge O\nstake O\nin O\nthe O\nWTO B-ORG\n, O\n\" O\nsaid O\nDesmond B-PER\nSupple I-PER\n, O\neconomist O\nat O\nresearch O\nhouse O\nI.D.E.A B-ORG\n. O\n\n\" O\nSingapore B-LOC\nstands O\nto O\nbenefit O\nmore O\nthan O\nmost O\nfrom O\ncontinued O\nglobal O\ntrade O\nliberalisation O\nas O\ntrade O\nis O\nthe O\nengine O\nof O\nits O\ngrowth O\n, O\naccounting O\nfor O\nnearly O\nthree O\ntimes O\nits O\ngross O\ndomestic O\nproduct O\n. O\n\" O\n\nThe O\ncity-state O\nmet O\nU.S. B-LOC\nopposition O\ntwo O\nyears O\nago O\nin O\nits O\nbid O\nto O\nhost O\nthe O\nmeeting O\n, O\nexpected O\nto O\ngather O\n4,000 O\nofficials O\nfrom O\n160 O\ncountries O\nfrom O\nDecember O\n9 O\nto O\n13 O\n. O\n\nIn O\na O\nstand O\nsome O\nanalysts O\nlinked O\nto O\ncontroversy O\nover O\nSingapore B-LOC\n's O\ncaning O\nof O\nan O\nAmerican B-MISC\nteenager O\nfor O\nvandalism O\n, O\nthen-U.S. B-MISC\nTrade O\nRepresentative O\nMickey B-PER\nKantor I-PER\nhad O\nsaid O\nthe O\nmeeting O\nought O\nto O\nbe O\nheld O\nwhere O\nthe O\nWTO B-ORG\nwas O\ngoing O\nto O\nbe O\nheadquartered O\n. O\n\nThat O\nwould O\nhave O\nmeant O\nGeneva B-LOC\n. O\n\nBut O\nSingapore B-LOC\nhad O\nthe O\nsupport O\nof O\nother O\nWTO B-ORG\nmembers O\n. O\n\nDerek B-PER\nda I-PER\nCunha I-PER\n, O\nsenior O\nfellow O\nat O\nthe O\nInstitute B-ORG\nof I-ORG\nPolicy I-ORG\nStudies I-ORG\n( O\nISEAS B-ORG\n) O\n, O\nsaid O\nSingapore B-LOC\n's O\nhosting O\nof O\nthe O\nconference O\n\" O\ncarries O\na O\ngreat O\ndeal O\nof O\nsymbolism O\nfor O\nthe O\ncity-state O\n, O\nunderscoring O\nits O\ncommitment O\nto O\nfree O\ntrade O\nand O\nits O\ntrading O\nlinks O\nacross O\nthe O\nglobe O\n. O\n\" O\n\nThere O\nis O\nthe O\ninternational O\nprestige O\nSingapore B-LOC\nwould O\nenjoy O\n, O\nbut O\n\" O\nmore O\nimportantly O\nthere O\nis O\na O\ngenuine O\nnational O\ninterest O\nin O\nfostering O\nbetter O\nglobal O\nfree O\ntrade O\nand O\nan O\nopen O\nmarket O\n\" O\n, O\nsaid O\nTan B-PER\nKong I-PER\nYam I-PER\n, O\nhead O\nof O\nBusiness O\nPolicy O\nat O\nthe O\nNational B-ORG\nUniversity I-ORG\nof I-ORG\nSingapore I-ORG\n. O\n\nAt O\nthe O\nministerial O\nmeeting O\n, O\ntrade O\nministers O\nwill O\nreview O\nthe O\nwork O\nof O\nthe O\nWTO B-ORG\nand O\nthe O\nimplementation O\nof O\nthe O\nUruguay B-LOC\nRound O\nfree O\ntrade O\ncommitments O\nunder O\nits O\npredecessor O\nthe O\nGeneral B-MISC\nAgreement I-MISC\non I-MISC\nTariffs I-MISC\nand I-MISC\nTrade I-MISC\n( O\nGATT B-MISC\n) O\n. O\n\nIn O\nJune O\n, O\nthe O\nWTO B-ORG\nhailed O\nSingapore B-LOC\nfor O\nits O\nopen O\nmarket O\npolicies O\nbut O\nthe O\nEuropean B-ORG\nUnion I-ORG\nand O\nother O\ntrading O\npowers O\ncalled O\non O\nSingapore B-LOC\nto O\nspeed O\nup O\nthe O\nopening O\nof O\nits O\nservices O\nsector O\n. O\n\nSupple B-PER\nsaid O\nthe O\nstruggle O\nthat O\nSingapore B-LOC\nhad O\nto O\nwage O\nin O\nvying O\nto O\nhost O\nthe O\nmeeting O\nwould O\nbe O\nrepeated O\nduring O\nthe O\ntalks O\n. O\n\n\" O\nThere O\nis O\ntension O\nat O\nevery O\nstep O\nof O\nthe O\nway O\n, O\n\" O\nsince O\na O\nbattle O\nline O\nbetween O\nthe O\nWest O\nand O\ndeveloping O\ncountries O\nhas O\nbeen O\ndrawn O\nover O\nthe O\nissue O\nof O\nlinking O\ntrade O\nliberalisation O\nwith O\nlabour O\nrights O\n, O\nhe O\nsaid O\n. O\n\nSupple B-PER\nsaid O\nhosting O\nthe O\nmeeting O\ncarried O\nprestige O\nfor O\nSingapore B-LOC\n, O\n\" O\nhowever O\n, O\nthis O\nis O\nquite O\nintangible O\nas O\nthe O\nprestige O\nfactor O\nmay O\nnot O\nnecessarily O\nlead O\nto O\nany O\nadditional O\ninvestment O\nand O\ntrade O\nflows O\nto O\nthis O\nregion O\n. O\n\" O\n\nFrom O\na O\ncommercial O\npoint O\nof O\nview O\n, O\nthe O\nmeeting O\nwould O\nbe O\ngood O\nfor O\nSingapore B-LOC\n's O\ntourism O\nindustry O\n, O\nTan B-PER\nsaid O\n. O\n\nA O\nlarge O\npart O\nof O\nSingapore B-LOC\n's O\nworkforce O\nwould O\nbe O\nmobilised O\nto O\nensure O\nthe O\nmeeting O\nwould O\nrun O\nwithout O\na O\nglitch O\nbut O\nthe O\naverage O\nSingaporean B-MISC\n\" O\nwould O\nprobably O\nnot O\nbe O\ntoo O\nconcerned O\nabout O\nsome O\nof O\nthe O\nissues O\n, O\n\" O\nTan B-PER\nsaid O\n. O\n\n\" O\nBut O\nthe O\nmore O\neducated O\npublic O\nwill O\nrealise O\nthat O\nthese O\nkind O\nof O\nthings O\nare O\nimportant O\nfor O\nSingapore B-LOC\nas O\na O\nsmall O\neconomy O\n. O\n\" O\n\nSupple B-PER\nsaid O\nany O\npolitical O\ngains O\nthe O\nSingapore B-LOC\ngovernment O\nwould O\nget O\nfrom O\nthe O\nWTO B-ORG\nmeeting O\n-- O\nahead O\nof O\na O\ngeneral O\nelection O\ndue O\nby O\nApril O\n1997 O\n-- O\nwould O\ndepend O\non O\nhow O\nsuccessful O\nit O\nwas O\nin O\npushing O\nits O\neconomic O\nagenda O\n. O\n\n\" O\nIf O\nthere O\nare O\nany O\nmovements O\ntoward O\nfreer O\ntrade O\n, O\nthen O\nSingapore B-LOC\n's O\neconomy O\nand O\nthe O\nelectorate O\nwould O\ngain O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nBut O\nI O\ndo O\nn't O\nthink O\nit O\nwould O\nbe O\nwise O\nto O\nplay O\nup O\nthe O\npolitical O\naspect O\nof O\nthis O\n. O\n\nI O\nthink O\npolitical O\nissues O\nwill O\ntake O\nsecondary O\nimportance O\nto O\nall O\nthese O\neconomic O\nissues O\nthat O\nwill O\nbe O\ndisplayed O\n. O\n\" O\n\n-DOCSTART- O\n\nJapan B-LOC\nNTT B-ORG\nsays O\nhopes O\nto O\nstart O\nint'l O\nbusiness O\nsoon O\n. O\n\nTOKYO B-LOC\n1996-12-06 O\n\nNippon B-ORG\nTelegraph I-ORG\nand I-ORG\nTelephone I-ORG\nCorp I-ORG\n( O\nNTT B-ORG\n) O\nsaid O\non O\nFriday O\nthat O\nit O\nhopes O\nto O\nmove O\ninto O\nthe O\ninternational O\ntelecommunications O\nbusiness O\nas O\nsoon O\nas O\npossible O\nfollowing O\nthe O\ngovernment O\n's O\ndecision O\nto O\nsplit O\nNTT B-ORG\ninto O\nthree O\nfirms O\nunder O\na O\nholding O\ncompany O\n. O\n\n\" O\nWe O\nhope O\nto O\nstart O\ninternational O\ntelephone O\nbusiness O\nas O\nsoon O\nas O\npossible O\n, O\n\" O\na O\ncompany O\nofficial O\ntold O\nReuters B-ORG\n. O\n\nThe O\nofficial O\nsaid O\nthe O\nlatest O\ngovernment O\ndecision O\nto O\nsplit O\nthe O\ncompany O\nunder O\na O\nholding O\ncompany O\nwould O\nallow O\nflexibility O\nin O\nNTT B-ORG\n's O\ninternational O\nphone O\nbusiness O\n. O\n\nEarlier O\n, O\nPosts O\nand O\nTelecommunications O\nMinister O\nHisao B-PER\nHorinouchi I-PER\ntold O\na O\nnews O\nconference O\nthe O\ngovernment O\nplans O\nto O\nsplit O\nNTT B-ORG\ninto O\nthree O\nfirms O\nunder O\na O\nholding O\ncompany O\n, O\nbut O\ndid O\nnot O\nspecify O\nwhen O\nthe O\nrestructuring O\nwould O\nlikely O\ntake O\neffect O\n. O\n\nOne O\nof O\nthe O\nthree O\nnew O\ncompanies O\nwill O\nbe O\na O\nlong-distance O\noperator O\nand O\nthe O\nother O\ntwo O\nwill O\nbe O\nlocal-call O\noperators O\n, O\nHorinouchi B-PER\nsaid O\n. O\n\nOne O\nof O\nthe O\nlocal O\nfirms O\nwill O\noperate O\nin O\nwest O\nJapan B-LOC\nand O\nthe O\nother O\nin O\neast O\nJapan B-LOC\n, O\nhe O\nadded O\n. O\n\nThe O\nlong-distance O\noperator O\nwill O\noffer O\ninternational O\nservices O\n, O\nHorinouchi B-PER\nsaid O\n. O\n\nThe O\nNTT B-ORG\nofficial O\nsaid O\nthe O\ntiming O\nof O\nthe O\nplanned O\nsplit-up O\nwas O\nuncertain O\nbecause O\nmore O\ndiscussions O\nby O\ngovernment O\nofficials O\nwere O\nrequired O\n. O\n\n-DOCSTART- O\n\nAhold B-ORG\nlaunches O\nAsian B-MISC\nfood O\ndiscount O\nstores O\n. O\n\nZAANDAM B-LOC\n, O\nNetherlands B-LOC\n1996-12-06 O\n\nDutch B-MISC\nsupermarkets O\ngroup O\nAhold B-ORG\nNV I-ORG\nsaid O\non O\nFriday O\nit O\nhad O\nlaunched O\na O\nsecond O\nfood O\nstore O\nformat O\nfor O\nAsian B-MISC\nconsumers O\ntoday O\n, O\nopening O\n16 O\nBILO B-MISC\nfood O\ndiscount O\nstores O\nin O\nMalaysia B-LOC\n. O\n\nThe O\nBILO B-MISC\nstores O\nare O\nlocated O\nin O\nMalysia B-LOC\n's O\ncapital O\nKuala B-LOC\nLumpur I-LOC\nand O\nin O\nthe O\ncountry O\n's O\nsecond O\ncity O\nJohor B-LOC\nBahru I-LOC\n. O\n\nThe O\ndiscount O\nprice O\nformat O\nstore O\nBILO B-MISC\nis O\nto O\ncomplement O\nAhold B-ORG\n's O\nfull O\nservice O\nsupermarket O\nTOPS B-MISC\n, O\nrecently O\nlaunched O\nin O\nAsia B-LOC\n. O\n\n\" O\nIn O\nthe O\ncoming O\nfive O\nto O\nten O\nyears O\n, O\nAhold B-ORG\nplans O\nto O\nopen O\nmany O\nmore O\nstores O\nof O\nboth O\nformats O\n, O\nmaking O\nTOPS B-MISC\nand O\nBILO B-MISC\nhousehold O\nnames O\nin O\nthe O\nregion O\n, O\n\" O\nAhold B-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\nAs O\nwell O\nas O\nits O\nactivities O\nin O\nAsia B-LOC\n, O\nDutch B-MISC\nretail O\ngroup O\nAhold B-ORG\nhas O\na O\nstrong O\npresence O\nin O\nEurope B-LOC\n, O\nin O\nthe O\nU.S. B-LOC\nand O\nthe O\ncompany O\nrecently O\nannounced O\na O\njoint O\nventure O\nagreement O\nin O\nBrazil B-LOC\n. O\n\nAhold B-ORG\nhas O\nannualised O\nsales O\nof O\napproximately O\nUS$ B-MISC\n24 O\nbillion O\n, O\nand O\nemploys O\n180,000 O\npeople O\nworldwide O\n. O\n\n-- O\nAmsterdam B-LOC\nnewsroom O\n+31 O\n20 O\n504 O\n5000 O\n, O\nFax O\n+31 O\n20 O\n504 O\n504 O\n\n-DOCSTART- O\n\nALPINE O\nSKIING-WOMEN O\n'S O\nWORLD B-MISC\nCUP I-MISC\nSUPER O\nG O\nWINNER O\nPROFILE O\n. O\n\nVAIL B-LOC\n, O\nColorado B-LOC\n1996-12-07 O\n\nProfile O\nof O\nthe O\nwinner O\nof O\nSaturday O\n's O\nwomen O\n's O\nWorld B-MISC\nCup I-MISC\nsuper O\nG O\nrace O\n: O\n\nName O\n: O\nSvetlana B-PER\nGladishiva I-PER\n\nAge O\n: O\n25 O\n\nNation O\n: O\nRussia B-LOC\n\nPrevious O\nWorld B-MISC\nCup I-MISC\nvictories O\n: O\nNone O\n\nOther O\nFacts O\n: O\nGladishiva B-PER\nwon O\na O\nsilver O\nmedal O\nin O\nsuper O\nG O\nat O\nthe O\n1994 O\nLillehammer B-LOC\nWinter B-MISC\nOlympics I-MISC\nand O\na O\nbronze O\nmedal O\nin O\ndownhill O\nat O\nthe O\n1991 O\nWorld B-MISC\nChampionships I-MISC\n. O\n\n-DOCSTART- O\n\nALPINE O\nSKIING-WOMEN O\n'S O\nWORLD B-MISC\nCUP I-MISC\nSUPER O\nG O\nRESULTS O\n. O\n\nVAIL B-LOC\n, O\nColorado B-LOC\n1996-12-07 O\n\nProvisional O\nresults O\nfrom O\n\nSaturday O\n's O\nwomen O\n's O\nWorld B-MISC\nCup I-MISC\nsuper O\nG O\nrace O\n: O\n\n1. O\nSvetlana B-PER\nGladishiva I-PER\n( O\nRussia B-LOC\n) O\none O\nminute O\n17.76 O\nseconds O\n\n2. O\nPernila B-PER\nWiberg I-PER\n( O\nSweden B-LOC\n) O\n1:17.97 O\n\n3. O\nCarole B-PER\nMontillet I-PER\n( O\nFrance B-LOC\n) O\n1:18.11 O\n\n4. O\nHilde B-PER\nGerg I-PER\n( O\nGermany B-LOC\n) O\n1:18.15 O\n\n5. O\nIsolde B-PER\nKostner I-PER\n( O\nItaly B-LOC\n) O\n1:18.19 O\n\n6. O\nWarwara B-PER\nZelenskaja I-PER\n( O\nRussia B-LOC\n) O\n1:18.21 O\n\n7. O\nMadlen B-PER\nBrigger-Summermatter I-PER\n( O\nSwitzerland B-LOC\n) O\n1:18.23 O\n\n8. O\nFlorence B-PER\nMasnada I-PER\n( O\nFrance B-LOC\n) O\n1:18.31 O\n\n9. O\nKatja B-PER\nSeizinger I-PER\n( O\nGermany B-LOC\n) O\n1:18.32 O\n\n10= O\nMartina B-PER\nErtl I-PER\n( O\nGermany B-LOC\n) O\n1:18.48 O\n\n10= O\nStefanie B-PER\nSchuster I-PER\n( O\nAustria B-LOC\n) O\n1:18.48 O\n\n12. O\nBibiana B-PER\nPerez I-PER\n( O\nItaly B-LOC\n) O\n1:18.52 O\n\n13. O\nBarbara B-PER\nMerlin I-PER\n( O\nItaly B-LOC\n) O\n1:18.67 O\n\n14. O\nSybille B-PER\nBrauner I-PER\n( O\nGermany B-LOC\n) O\n1:18.81 O\n\n15. O\nKatharina B-PER\nGutensohn I-PER\n( O\nGermany B-LOC\n) O\n1:18.92 O\n\n16. O\nLeatitia B-PER\nDalloz I-PER\n( O\nFrance B-LOC\n) O\n1:18.96 O\n\n17. O\nRenate B-PER\nGoetschl I-PER\n( O\nAustria B-LOC\n) O\n1:18.98 O\n\n18. O\nMarianne B-PER\nBrechu I-PER\n( O\nFrance B-LOC\n) O\n1:19.02 O\n\n19. O\nHeidi B-PER\nZurbriggen I-PER\n( O\nSwitzerland B-LOC\n) O\n1:19.03 O\n\n20. O\nSpela B-PER\nBracun I-PER\n( O\nSlovenia B-LOC\n) O\n1:19.07 O\n\n21. O\nShannon B-PER\nNobis I-PER\n( O\nU.S. B-LOC\n) O\n1:19.08 O\n\n22= O\nRegine B-PER\nCavagnoud I-PER\n( O\nFrance B-LOC\n) O\n1:19.21 O\n\n22= O\nAnita B-PER\nWachter I-PER\n( O\nAustria B-LOC\n) O\n1:19.21 O\n\n24. O\nMegan B-PER\nGerety I-PER\n( O\nU.S. B-LOC\n) O\n1:19.39 O\n\n25. O\nHilary B-PER\nLindh I-PER\n( O\nU.S. B-LOC\n) O\n1:19.41 O\n\n26= O\nCatherine B-PER\nBorghi I-PER\n( O\nSwitzerland B-LOC\n) O\n1:19.44 O\n\n26= O\nMichaela B-PER\nDorfmeister I-PER\n( O\nAustria B-LOC\n) O\n1:19.44 O\n\n28. O\nAlexandra B-PER\nMeissnitzer I-PER\n( O\nAustria B-LOC\n) O\n1:19.53 O\n\n29. O\nIngeborg B-PER\nHelen I-PER\nMarken I-PER\n( O\nNorway B-LOC\n) O\n1:19.54 O\n\n30. O\nMonika B-PER\nTschirky I-PER\n( O\nSwitzerland B-LOC\n) O\n1:19.60 O\n\nThe O\nresults O\nwere O\ndeclared O\nofficial O\n. O\n\n-DOCSTART- O\n\nALPINE O\nSKIING-GLADISHIVA B-MISC\nWINS O\nWORLD B-MISC\nCUP I-MISC\nSUPER O\nG O\n. O\n\nVAIL B-LOC\n, O\nColorado B-LOC\n1996-12-07 O\n\nSvetlana B-PER\nGladishiva I-PER\nof O\nRussia B-LOC\nwon O\nthe O\nwomen O\n's O\nWorld B-MISC\nCup I-MISC\nSuper O\nG O\nrace O\non O\nSaturday O\n. O\n\nPernilla B-PER\nWiberg I-PER\nof O\nSweden B-LOC\nfinished O\nsecond O\nand O\nCarole B-PER\nMontillet I-PER\nof O\nFrance B-LOC\ncame O\nin O\nthird O\n, O\naccording O\nto O\nprovisional O\nresults O\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nTHIRD O\nROUND O\nOF O\nJCPENNEY B-MISC\nCLASSIC I-MISC\nWASHED O\nOUT O\n. O\n\nTARPON B-LOC\nSPRINGS I-LOC\n, O\nFlorida B-LOC\n1996-12-07 O\n\nHeavy O\nrains O\non O\nSaturday O\nwashed O\nout O\nthe O\nthird O\nround O\nof O\nthe O\n$ O\n1.5 O\nmillion O\nJCPenney B-MISC\nClassic I-MISC\nat O\nthe O\nInnisbrook B-LOC\nHilton I-LOC\nResort I-LOC\n. O\n\nOfficials O\nsaid O\nthe O\ntournament O\nwould O\nbe O\nreduced O\nto O\n54 O\nholes O\nfor O\nthe O\nfirst O\ntime O\nin O\nits O\n37-year O\nhistory O\n. O\n\nThe O\nfinal O\nround O\nof O\nthe O\nspecial O\nevent O\n, O\nwhich O\npairs O\nplayers O\nfrom O\nthe O\nPGA B-ORG\nand O\nLPGA B-ORG\nTours O\n, O\nwill O\nbe O\nplayed O\nin O\nthe O\nalternate O\nshot O\nformat O\non O\nSunday O\n. O\n\nThe O\nduo O\nof O\nPat B-PER\nHurst I-PER\nand O\nScott B-PER\nMcCarron I-PER\nwere O\ntied O\nfor O\nthe O\nlead O\nwith O\nthe O\nteam O\nof O\nDonna B-PER\nAndrews I-PER\nand O\nMike B-PER\nHulbert I-PER\nat O\n13-under-par O\n129 O\nthrough O\n36 O\nholes O\n. O\n\nThe O\ntandem O\nof O\nreigning O\nU.S. B-LOC\nAmateur O\nchampions O\nKelli B-PER\nKuehne I-PER\nand O\nTiger B-PER\nWoods I-PER\nwere O\nanother O\nshot O\nback O\nat O\n12-under O\n130 O\n. O\n\nDefending O\nchampions O\nBeth B-PER\nDaniel I-PER\nand O\nDavis B-PER\nLove I-PER\nwill O\nstart O\nthe O\nfinal O\nround O\nsix O\nshots O\noff O\nthe O\npace O\n. O\n\n-DOCSTART- O\n\nALPINE O\nSKIING-WOMEN O\n'S O\nDOWNHILL O\nWINNER O\nPROFILE O\n. O\n\nVAIL B-LOC\n, O\nColorado B-LOC\n1996-12-07 O\n\nProfile O\nof O\nthe O\nwinner O\nof O\nSaturday O\n's O\nwomen O\n's O\nWorld B-MISC\nCup I-MISC\ndownhill O\nrace O\n: O\n\nName O\n: O\nRenate B-PER\nGoetschl I-PER\n\nAge O\n: O\n20 O\n\nNation O\n: O\nAustria B-LOC\n\nPrevious O\nvictories O\n( O\ntwo O\n) O\n: O\nslalom O\n, O\nLillehammer B-LOC\nNorway B-LOC\n, O\n1993 O\n; O\nsuper O\nG O\n, O\nFlachau B-LOC\n, O\nAustria B-LOC\n, O\n1995 O\n. O\n\nOther O\nfacts O\n: O\nAs O\na O\nqualifier O\nfor O\nthe O\n1993 B-MISC\nWorld I-MISC\nCup I-MISC\nfinals O\nthrough O\nEuropa B-MISC\nCup I-MISC\nresults O\n, O\n16-year-old O\nGoetschl B-PER\nwon O\nthe O\nslalom O\nto O\nbecome O\nhistory O\n's O\nyoungest O\nWorld B-MISC\nCup I-MISC\nvictor O\n. O\n\n-DOCSTART- O\n\nALPINE O\nSKIING-WOMEN O\n'S O\nWORLD B-MISC\nCUP I-MISC\nSTANDINGS O\n. O\n\nVAIL B-LOC\n, O\nColorado B-LOC\n1996-12-07 O\n\nWomen O\n's O\nWorld B-MISC\nCup I-MISC\n\nstandings O\nafter O\nSaturday O\n's O\ndownhill O\nrace O\n: O\n\nDownhill O\nStandings O\n\n1. O\nKatja B-PER\nSeizinger I-PER\n( O\nGermany B-LOC\n) O\n180 O\npoints O\n\n2. O\nRenate B-PER\nGoetschl I-PER\n( O\nAustria B-LOC\n) O\n132 O\n\n3. O\nCarole B-PER\nMontillet I-PER\n( O\nFrance B-LOC\n) O\n86 O\n\n4. O\nPernilla B-PER\nWiberg I-PER\n( O\nSweden B-LOC\n) O\n75 O\n\n5. O\nHeidi B-PER\nZurbriggen I-PER\n( O\nSwitzerland B-LOC\n) O\n69 O\n\n6. O\nRegina B-PER\nHaeusl I-PER\n( O\nGermany B-LOC\n) O\n66 O\n\n7. O\nAlexandra B-PER\nMeissnitzer I-PER\n( O\nAustria B-LOC\n) O\n65 O\n\n8. O\nIsolde B-PER\nKostner I-PER\n( O\nItaly B-LOC\n) O\n60 O\n\n9. O\nIngeborg B-PER\nHelen I-PER\nMarkein O\n( O\nNorway B-LOC\n) O\n58 O\n\n10= O\nMegan B-PER\nGerety I-PER\n( O\nU.S. B-LOC\n) O\n51 O\n\n10= O\nWarwara B-PER\nZelenskaja I-PER\n( O\nRussia B-LOC\n) O\n51 O\n\n10= O\nFlorence B-LOC\nMasnada B-PER\n( O\nFrance B-LOC\n) O\n51 O\n\n13= O\nPicabo B-PER\nStreet I-PER\n( O\nU.S. B-LOC\n) O\n50 O\n\n13= O\nStefanie B-PER\nSchuster I-PER\n( O\nAustria B-LOC\n) O\n50 O\n\n15. O\nMiriam B-PER\nVogt I-PER\n( O\nGermany B-LOC\n) O\n47 O\n\n16. O\nBibiana B-PER\nPerez I-PER\n( O\nItaly B-LOC\n) O\n45 O\n\n17. O\nHilde B-PER\nGerg I-PER\n( O\nGermany B-LOC\n) O\n42 O\n\n18. O\nBarbara B-PER\nMerlin I-PER\n( O\nGermany B-LOC\n) O\n38 O\n\n19= O\nKate B-PER\nPace I-PER\nLindsay I-PER\n( O\nCanada B-LOC\n) O\n23 O\n\n19= O\nSvetlana B-PER\nGladishiva I-PER\n( O\nRussia B-LOC\n) O\n23 O\n\n19= O\nRegine B-PER\nCavagnoud I-PER\n( O\nFrance B-LOC\n) O\n23 O\n\nOverall O\nwomen O\n's O\nWorld B-MISC\nCup I-MISC\nstandings O\nleaders O\nafter O\n\nSaturday O\n's O\ndownhill O\nand O\nsuper O\nG O\nraces O\n: O\n\n1. O\nKatja B-PER\nSeizinger I-PER\n( O\nGermany B-LOC\n) O\n414 O\npoints O\n\n2. O\nPernilla B-PER\nWiberg I-PER\n( O\nSweden B-LOC\n) O\n353 O\n\n3. O\nHide B-PER\nGerg I-PER\n( O\nGermany B-LOC\n) O\n276 O\n\n4. O\nAnita B-PER\nWachter I-PER\n( O\nAustria B-LOC\n) O\n180 O\n\n5. O\nIsolde B-PER\nKostner I-PER\n( O\nItaly B-LOC\n) O\n157 O\n\n6. O\nHeidi B-PER\nZurbriggen I-PER\n( O\nSwitzerland B-LOC\n) O\n153 O\n\n7. O\nWarwara B-PER\nZelenskaja I-PER\n( O\nRussia B-LOC\n) O\n151 O\n\n8= O\nRenate B-PER\nGoetschl I-PER\n( O\nAustria B-LOC\n) O\n146 O\n\n8= O\nCarole B-PER\nMontillet I-PER\n( O\nFrance B-LOC\n) O\n146 O\n\n10. O\nSvetlana B-PER\nGladishiva I-PER\n( O\nRussia B-LOC\n) O\n137 O\n\n11. O\nFlorence B-LOC\nMasnada B-PER\n( O\nFrance B-LOC\n) O\n133 O\n\n12. O\nDeborah B-PER\nCompagnoni I-PER\n( O\nItaly B-LOC\n) O\n120 O\n\n13. O\nMartina B-PER\nErtl I-PER\n( O\nGermany B-LOC\n) O\n119 O\n\n14. O\nAlexandra B-PER\nMeissnitzer I-PER\n( O\nAustria)118 O\n\n15. O\nUrska B-PER\nHorvat I-PER\n( O\nSlovenia B-LOC\n) O\n108 O\n\n16= O\nClaudia B-PER\nRiegler I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n100 O\n\n16= O\nSabina B-PER\nPanzanini I-PER\n( O\nItaly B-LOC\n) O\n100 O\n\n18. O\nBarbara B-PER\nMerlin I-PER\n( O\nItaly B-LOC\n) O\n92 O\n\n19. O\nStefanie B-PER\nSchuster I-PER\n( O\nAustria B-LOC\n) O\n89 O\n\n20. O\nMiriam B-PER\nVogt I-PER\n( O\nGermany B-LOC\n) O\n76 O\n\nSuper B-MISC\nG I-MISC\nstandings O\n: O\n\n1. O\nPernilla B-PER\nWiberg I-PER\n( O\nSweden B-LOC\n) O\n180 O\n\n2. O\nHilde B-PER\nGerg I-PER\n( O\nGermany B-LOC\n) O\n130 O\n\n3. O\nSvetland B-PER\nGladishiva I-PER\n( O\nRussia B-LOC\n) O\n114 O\n\n4. O\nWarwara B-PER\nZelenskaja I-PER\n( O\nRussia B-LOC\n) O\n100 O\n\n5. O\nFlorence B-PER\nMasnada I-PER\n( O\nFrance B-LOC\n) O\n82 O\n\n6. O\nKatja B-PER\nSeizinger I-PER\n( O\nGermany B-LOC\n) O\n74 O\n\n7. O\nIsolde B-PER\nKostner I-PER\n( O\nItaly B-LOC\n) O\n65 O\n\n8. O\nCarole B-PER\nMontillet I-PER\n( O\nFrance B-LOC\n) O\n60 O\n\n9. O\nMartina B-PER\nErtl I-PER\n( O\nGermany B-LOC\n) O\n58 O\n\n10. O\nAnita B-PER\nWachter I-PER\n( O\nAustria B-LOC\n) O\n49 O\n\n11. O\nHeidi B-PER\nZurbriggen I-PER\n( O\nSwitzerland B-LOC\n) O\n43 O\n\n12= O\nMadlen B-PER\nBrigger-Summermatter I-PER\n( O\nSwitzerland B-LOC\n) O\n42 O\n\n12= O\nBarbara B-PER\nMerlin I-PER\n( O\nItaly B-LOC\n) O\n42 O\n\n12= O\nKatharina B-PER\nGutensohn I-PER\n( O\nGermany B-LOC\n) O\n42 O\n\n15. O\nStefanie B-PER\nSchuster I-PER\n( O\nAustria B-LOC\n) O\n39 O\n\n16. O\nLeatitia B-PER\nDalloz I-PER\n( O\nFrance B-LOC\n) O\n33 O\n\n17. O\nBibiana B-PER\nPerez I-PER\n( O\nItaly B-LOC\n) O\n30 O\n\n18= O\nMiriam B-PER\nVogt I-PER\n( O\nGermany B-LOC\n) O\n29 O\n\n18= O\nMarianne B-PER\nBrechu I-PER\n( O\nFrance B-LOC\n) O\n29 O\n\n20. O\nAlexandra B-PER\nMeissnitzer I-PER\n( O\nAustria B-LOC\n) O\n27 O\n\nNation B-MISC\n's I-MISC\nCup I-MISC\nstandings O\n: O\n\n1. O\nAustria B-LOC\n1,973 O\npoints O\n\n2. O\nGermany B-LOC\n1,135 O\n\n3. O\nSwitzerland B-LOC\n972 O\n\n4. O\nItaly B-LOC\n887 O\n\n5. O\nFrance B-LOC\n853 O\n\n6. O\nNorway B-LOC\n746 O\n\n7. O\nSweden B-LOC\n673 O\n\n8. O\nSlovenia B-LOC\n432 O\n\n9. O\nRussia B-LOC\n288 O\n\n10. O\nUnited B-LOC\nStates I-LOC\n164 O\n\n-DOCSTART- O\n\nALPINE O\nSKIING-WOMEN O\n'S O\nWORLD B-MISC\nCUP I-MISC\nDOWNHILL O\nRESULTS O\n. O\n\nVAIL B-LOC\n, O\nColorado B-LOC\n1996-12-07 O\n\nProvisional O\nresults O\nfrom O\n\nSaturday O\n's O\nwomen O\n's O\nWorld B-MISC\nCup I-MISC\ndownhill O\nrace O\n: O\n\n1. O\nRenate B-PER\nGoetschl I-PER\n( O\nAustria B-LOC\n) O\none O\nminute O\n47.71 O\nseconds O\n\n2. O\nKatja B-PER\nSeizinger I-PER\n( O\nGermany B-LOC\n) O\n1:48.53 O\n\n3. O\nIsolde B-PER\nKostner I-PER\n( O\nItaly B-LOC\n) O\n1:48.91 O\n\n4. O\nAlexandra B-PER\nMeissnitzer I-PER\n( O\nAustria B-LOC\n) O\n1:49.13 O\n\n5. O\nMegan B-PER\nGerety I-PER\n( O\nU.S. B-LOC\n) O\n1:49.26 O\n\n6. O\nMiriam B-PER\nVogt I-PER\n( O\nGermany B-LOC\n) O\n1:49.28 O\n\n7. O\nStefanie B-PER\nSchuster I-PER\n( O\nAustria B-LOC\n) O\n1:49.38 O\n\n8. O\nIngeborg B-PER\nHelen I-PER\nMarken I-PER\n( O\nNorway B-LOC\n) O\n1:49.41 O\n\n9. O\nFlorence B-PER\nMasnada I-PER\n( O\nFrance B-LOC\n) O\n1:49.51 O\n\n10. O\nRegina B-PER\nHaeusl I-PER\n( O\nGermany B-LOC\n) O\n1:49.53 O\n\n11. O\nHeidi B-PER\nZurbriggen I-PER\n( O\nSwitzerland B-LOC\n) O\n1:49.65 O\n\n12. O\nWarwara B-PER\nZelenskaja I-PER\n( O\nRussia B-LOC\n) O\n1:49.66 O\n\n13. O\nBarbara B-PER\nMerlin I-PER\n( O\nItaly B-LOC\n) O\n1:49.76 O\n\n14. O\nHilde B-PER\nGerg I-PER\n( O\nGermany B-LOC\n) O\n1:49.84 O\n\n15. O\nMartina B-PER\nErtl I-PER\n( O\nGermany B-LOC\n) O\n1:49.85 O\n\n16. O\nPernilla B-PER\nWiberg I-PER\n( O\nSweden B-LOC\n) O\n1:49.88 O\n\n17. O\nSvetlana B-PER\nGladishiva I-PER\n( O\nRussia B-LOC\n) O\n1:50.03 O\n\n18. O\nAnita B-PER\nWachter I-PER\n( O\nAustria B-LOC\n) O\n1:50.10 O\n\n19. O\nSpela B-PER\nBracun I-PER\n( O\nSlovenia B-LOC\n) O\n1:50.40 O\n\n20. O\nRegine B-PER\nCavagnoud I-PER\n( O\nFrance B-LOC\n) O\n1:50.51 O\n\n21. O\nKate B-PER\nPace I-PER\nLindsay I-PER\n( O\nCanada B-LOC\n) O\n1:50.54 O\n\n22. O\nBibiana B-PER\nPerez I-PER\n( O\nItaly B-LOC\n) O\n1:50.65 O\n\n23. O\nHilary B-PER\nLindh I-PER\n( O\nUnited B-LOC\nStates I-LOC\n) O\n1:50.69 O\n\n24. O\nCatherine B-PER\nBorghi I-PER\n( O\nSwitzerland B-LOC\n) O\n1:50.72 O\n\n25. O\nCarole B-PER\nMontillet I-PER\n( O\nFrance B-LOC\n) O\n1:50.91 O\n\n26. O\nBrigitte B-PER\nObermoser I-PER\n( O\nAustria B-LOC\n) O\n1:50.99 O\n\n27. O\nSybille B-PER\nBrauner I-PER\n( O\nGermay O\n) O\n1:51.04 O\n\n28. O\nGrete B-PER\nStroem I-PER\n( O\nNorway B-LOC\n) O\n1:51.07 O\n\n29. O\nPatrizia B-PER\nBassis I-PER\n( O\nItaly B-LOC\n) O\n1:51.13 O\n\n30. O\nAlessandra B-PER\nMerlin I-PER\n( O\nItaly B-LOC\n) O\n1:51.16 O\n\nThe O\nresults O\nwere O\ndeclared O\nofficial O\n. O\n\n-DOCSTART- O\n\nNORDIC O\nSKIING-WORLD B-MISC\nCUP I-MISC\nBIATHLON O\nRESULTS O\n. O\n\nOESTERSUND B-LOC\n, O\nSweden B-LOC\n1996-12-07 O\n\nResults O\nof O\nSaturday O\n's O\n\nWorld B-MISC\nCup I-MISC\nbiathlon O\nraces O\n: O\n\nMen O\n's O\n10 O\nkms O\n\n1. O\nVadim B-PER\nSashurin I-PER\n( O\nBelarus B-LOC\n) O\n26 O\nminutes O\n17.2 O\nseconds O\n( O\nno O\npenalty O\n\nrounds O\n) O\n\n2. O\nFrode B-PER\nAndresen I-PER\n( O\nNorway B-LOC\n) O\n26:17.8 O\n( O\n2 O\n) O\n\n3. O\nOle B-PER\nEinar I-PER\nBjorndalen I-PER\n( O\nNorway B-LOC\n) O\n26:24.9 O\n( O\n2 O\n) O\n\n4. O\nSven B-PER\nFischer I-PER\n( O\nGermany B-LOC\n) O\n26:28.2 O\n( O\n1 O\n) O\n\n5. O\nRicco B-PER\nGross I-PER\n( O\nGermany B-LOC\n) O\n26:33.0 O\n( O\n1 O\n) O\n\nWorld B-MISC\nCup I-MISC\nstandings O\n\n1. O\nFischer B-PER\n( O\nGermany B-LOC\n) O\n82 O\npoints O\n\n2. O\nPavel B-PER\nMuslimov I-PER\n( O\nRussia B-LOC\n) O\n82 O\n\n3. O\nSashurin B-PER\n68 O\n. O\n\nWomen O\n's O\n7.5 O\nkms O\n\n1. O\nOlga B-PER\nMelnik I-PER\n( O\nRussia B-LOC\n) O\n23:13.3 O\n( O\n0 O\n) O\n\n2. O\nSvetlana B-PER\nParamygina I-PER\n( O\nBelorus B-LOC\n) O\n23:58.6 O\n( O\n0 O\n) O\n\n3. O\nGunn B-PER\nMargit I-PER\nAndreassen I-PER\n( O\nNorway B-LOC\n) O\n24:00.4 O\n( O\n0 O\n) O\n\n4. O\nSimone B-PER\nGreiner-Petter-Memm I-PER\n( O\nGermany B-LOC\n) O\n24:09.5 O\n( O\n1 O\n) O\n\n5. O\nPetra B-PER\nBehle I-PER\n( O\nGermany B-LOC\n) O\n24:15.4 O\n( O\n2 O\n) O\n\nWorld B-MISC\nCup I-MISC\nstandings O\n\n1. O\nBehle B-PER\n89 O\n\n2. O\nParamygina B-PER\n79 O\n\n3. O\nGreiner-Petter-Memm B-PER\n78 O\n\n-DOCSTART- O\n\nALPINE O\nSKIING-GOETCHL O\nWINS O\nWORLD B-MISC\nCUP I-MISC\nDOWNHILL O\n. O\n\nVAIL B-LOC\n, O\nColorado B-LOC\n1996-12-07 O\n\nRenate B-PER\nGoetschl I-PER\nof O\nAustria B-LOC\nwon O\nthe O\nwomen O\n's O\nWorld B-MISC\nCup I-MISC\ndownhill O\nrace O\non O\nSaturday O\n, O\naccording O\nto O\nprovisional O\nresults O\n. O\n\nKatja B-PER\nSeizinger I-PER\nof O\nGermany B-LOC\nfinished O\nsecond O\nand O\nIslode B-PER\nKostner I-PER\nof O\nItaly B-LOC\ntook O\nthird O\n. O\n\n-DOCSTART- O\n\nBOBSLEIGH-SHIMER B-MISC\nPILOTS O\nUSA B-ORG\nIII I-ORG\nTO O\nSURPRISE O\nWIN O\n. O\n\nIGLS B-LOC\n, O\nAustria B-LOC\n1996-12-07 O\n\nBrian B-PER\nShimer I-PER\npiloted O\nUSA B-ORG\nIII I-ORG\nto O\na O\nsurprise O\nvictory O\nin O\na O\nWorld B-MISC\nCup I-MISC\ntwo-man O\nbobsleigh O\nrace O\non O\nSaturday O\n. O\n\nLying O\nfifth O\nafter O\nthe O\nfirst O\nrun O\n, O\nShimer B-PER\nand O\nbreakman O\nRandy B-PER\nJones I-PER\ndelivered O\na O\nnear-perfect O\nsecond O\ntrip O\ndown O\nthe O\n1976 O\nOlympic B-MISC\ncourse O\nfor O\nan O\naggregate O\ntime O\nof O\none O\nminute O\n45.91 O\nseconds O\n. O\n\nFirst O\nrun O\nleaders O\nGuenther B-PER\nHuber I-PER\nand O\nbreakman O\nAntonio B-PER\nTartaglia I-PER\nin O\nthe O\nItaly B-LOC\nI O\nsleigh O\nfinished O\nsecond O\ntwo-hundredths O\nof O\na O\nsecond O\nbehind O\nthe O\nAmericans B-MISC\n. O\n\nCanada B-ORG\nI I-ORG\n, O\nrepresented O\nby O\nPierre B-PER\nLueders I-PER\nand O\nbreakman O\nDave B-PER\nMacEachern I-PER\n, O\ncompleted O\nthe O\nthird O\nWorld B-MISC\ncup I-MISC\nevent O\nof O\nthe O\nwinter O\na O\nfurther O\none-hundredth O\nof O\na O\nsecond O\nbehind O\nthe O\nItalians B-MISC\n. O\n\nThe O\nCanadians B-MISC\n, O\nwinners O\nof O\nthe O\nopening O\ntwo O\nevents O\nin O\nAltenberg B-LOC\n, O\nGermany B-LOC\n, O\nand O\nLa B-LOC\nPlagne I-LOC\n, O\nFrance B-LOC\n, O\nincreased O\ntheir O\nlead O\nin O\nthe O\nWorld B-MISC\nCup I-MISC\nstandings O\n. O\n\nThey O\nhave O\n104 O\npoints O\n, O\n15 O\nahead O\nof O\nUSA B-ORG\nI I-ORG\n's O\nJim B-PER\nHerberich I-PER\nand O\nbreakman O\nGarrett B-PER\nHines I-PER\nwho O\nmanaged O\nonly O\n10th O\nplace O\non O\nSaturday O\n. O\n\n-DOCSTART- O\n\nSKIING-CHINESE B-MISC\nMAKE O\nPROMISING O\nFREESTYLE O\nSKIING O\nDEBUT O\n. O\n\nTIGNES B-LOC\n, O\nFrance B-LOC\n1996-12-07 O\n\nChina B-LOC\nmade O\na O\npromising O\ndebut O\non O\nthe O\nfreestyle O\nskiing O\nworld O\ncup O\ncircuit O\nin O\nan O\naerials O\nevent O\nin O\nthe O\nFrench B-MISC\nresort O\nof O\nTignes B-LOC\non O\nSaturday O\n. O\n\nWhile O\nthe O\nChinese B-MISC\nfailed O\nto O\ngain O\na O\nplace O\nin O\nthe O\nmen O\n's O\nfinal O\n, O\nthey O\nhad O\ntwo O\nin O\nthe O\ntop O\n10 O\nof O\nthe O\nwomen O\n's O\ncompetition O\n, O\nCuo B-PER\nDan I-PER\nfinishing O\na O\nrespectable O\nseventh O\nand O\nXu B-PER\nNannan I-PER\nninth O\n. O\n\nBut O\noverall O\n, O\nit O\nwas O\nFrance B-LOC\nand O\nCanada B-LOC\nwho O\ndominated O\nthe O\nday O\n. O\n\nAlexis B-PER\nBlanc I-PER\nand O\nSebastien B-PER\nFoucras I-PER\ngave O\nFrance B-LOC\na O\none-two O\nfinish O\nin O\nthe O\nfirst O\naerials O\ncompetition O\nof O\nthe O\nseason O\n. O\n\nBlanc B-PER\ncollected O\nhis O\nseventh O\ncareer O\nWorld B-MISC\nCup I-MISC\nwin O\nwith O\na O\ntwo O\njump O\ncombined O\nscore O\nof O\n238.36 O\npoints O\n, O\neasily O\nbeating O\nFoucras B-PER\n, O\nthe O\noverall O\nWorld B-MISC\nCup I-MISC\naerials O\nchampion O\n, O\nwho O\nwas O\na O\ndistant O\nsecond O\nwith O\n223.60 O\n. O\n\nCanada B-LOC\n's O\nJeff B-PER\nBean I-PER\n, O\nwho O\nhad O\nnever O\nfinished O\nhigher O\nthan O\nninth O\nin O\na O\nWorld B-MISC\nCup I-MISC\nevent O\n, O\nmade O\nhis O\nfirst O\ntrip O\nto O\nthe O\npodium O\ntaking O\nthird O\nplace O\nwith O\na O\nmark O\nof O\n209.96 O\n. O\n\nVeronica B-PER\nBrenner I-PER\nof O\nCanada B-LOC\n, O\nwho O\npicked O\nup O\nher O\nfirst O\ncareer O\nvictory O\nat O\nTignes B-LOC\nlast O\nyear O\n, O\nmade O\nit O\ntwo O\nwins O\nin O\na O\nrow O\nat O\nthe O\nFrench B-MISC\nresort O\ntaking O\nfirst O\nin O\nthe O\nwomen O\n's O\ncompetition O\nwith O\na O\nscore O\nof O\n170.42 O\n. O\n\nSwiss B-MISC\nskiers O\noccupied O\nthe O\nother O\ntwo O\nplaces O\non O\nthe O\npodium O\n, O\nKarin B-PER\nKuster I-PER\ntaking O\nsecond O\nwith O\n160.55 O\nnarrowly O\nahead O\nof O\nEvelyne B-PER\nLeu I-PER\nwith O\n160.36 O\n. O\n\n-DOCSTART- O\n\nBOBSLEIGH-WORLD B-MISC\nCUP I-MISC\nTWO-MAN O\nRESULTS O\n. O\n\nIGLS B-LOC\n, O\nAustria B-LOC\n1996-12-07 O\n\nResults O\nof O\na O\nWorld B-MISC\nCup I-MISC\ntwo-man O\nbobsleigh O\nevent O\non O\nSaturday O\n: O\n\n1. O\nUnited B-ORG\nStates I-ORG\nIII I-ORG\n( O\nBrian B-PER\nShimer I-PER\n, O\nRandy B-PER\nJones I-PER\n) O\none O\n\nminute O\n45.91 O\nseconds O\n( O\n52.90 O\n/ O\n53.01 O\n) O\n\n2. O\nItaly B-ORG\nI I-ORG\n( O\nGuenther B-PER\nHuber I-PER\n, O\nAntonio B-PER\nTartaglia I-PER\n) O\n1:45.93 O\n\n( O\n52.74 O\n/ O\n53.19 O\n) O\n\n3. O\nCanada B-ORG\nI I-ORG\n( O\nPierre B-PER\nLueders I-PER\n, O\nDave B-PER\nMacEachern I-PER\n) O\n1:45.94 O\n\n( O\n52.76 O\n/ O\n53.18 O\n) O\n\n4. O\nGerman B-ORG\nI I-ORG\n( O\nSepp B-PER\nDostthaler I-PER\n, O\nThomas B-PER\nLebsa I-PER\n) O\n1:45.95 O\n\n( O\n52.82 O\n/ O\n53.13 O\n) O\n\n5. O\nSwitzerland B-ORG\nI I-ORG\n( O\nReto B-PER\nGoetschi I-PER\n, O\nGuido B-PER\nAcklin I-PER\n) O\n1:45.98 O\n\n( O\n52.91 O\n/ O\n53.07 O\n) O\n\n6. O\nGermany B-ORG\nIII I-ORG\n( O\nDirk B-PER\nWiese I-PER\n, O\nJakobs B-PER\nMarco I-PER\n) O\n1:46.02 O\n\n( O\n52.89 O\n/ O\n53.13 O\n) O\n\n7. O\nCzech B-ORG\nRepublic I-ORG\nI I-ORG\n( O\nJiri B-PER\nDzmura I-PER\n, O\nPavel B-PER\nPolomsky I-PER\n) O\n\n1:46.06 O\n( O\n53.01 O\n/ O\n53.05 O\n) O\n\n8. O\nAustria B-ORG\nI I-ORG\n( O\nHubert B-PER\nSchoesser I-PER\n, O\nErwin B-PER\nArnold I-PER\n) O\n1:46.13 O\n\n( O\n52.92 O\n/ O\n53.21 O\n) O\n\n9. O\nBritain B-ORG\nI I-ORG\n( O\nSean B-PER\nOlsson I-PER\n, O\nDean B-PER\nWard I-PER\n) O\n1:46.26 O\n( O\n52.97/ O\n\n53.29 O\n) O\n\n10 O\nequal O\n. O\n\nUnited B-ORG\nStates I-ORG\nI I-ORG\n( O\nJim B-PER\nHerberich I-PER\n, O\nGarrett B-PER\n\nHines B-PER\n) O\n1:46.34 O\n( O\n53.14 O\n/ O\n53.20 O\n) O\nand O\nAustria B-ORG\nIII I-ORG\n\n( O\nHannes B-PER\nConti I-PER\n, O\nGeorg B-PER\nKuttner I-PER\n) O\n1:46.34 O\n( O\n53.30/ O\n\n53.04). O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nWOOLMER B-PER\nMAKES O\nSENTIMENTAL O\nRETURN O\nTO O\nKANPUR B-LOC\n. O\n\nKANPUR B-LOC\n, O\nIndia B-LOC\n1996-12-07 O\n\nSouth B-LOC\nAfrica I-LOC\n's O\ntrip O\nto O\nKanpur B-LOC\nfor O\nthe O\nthird O\ntest O\nagainst O\nIndia B-LOC\nhas O\ngiven O\nformer O\nEngland B-LOC\ntest O\ncricketer O\nBob B-PER\nWoolmer I-PER\nthe O\nchance O\nof O\na O\nsentimental O\nreturn O\nto O\nhis O\nbirthplace O\n. O\n\nWoolmer B-PER\nwas O\nborn O\nin O\nthe O\nnorthern O\ncity O\nof O\nKanpur B-LOC\nwhen O\nhis O\nfather O\nworked O\nthere O\nfor O\nan O\ninsurance O\ncompnay O\nand O\nwas O\nhimself O\nan O\nactive O\ncricketer O\n. O\n\n\" O\nIt O\n's O\nbeen O\na O\nsentimental O\njourney O\n... O\n\nA O\nvisit O\nto O\nIndia B-LOC\nis O\nalways O\nan O\nintriguing O\nexperience O\n, O\n\" O\nWoolmer B-PER\n, O\nnow O\nthe O\nSouth B-MISC\nAfrican I-MISC\ncoach O\n, O\nsaid O\non O\nSaturday O\n. O\n\nWoolmer B-PER\n, O\n48 O\n, O\nplayed O\n19 O\ntests O\nfor O\nEngland B-LOC\nbetween O\n1975 O\nand O\n1981 O\n. O\n\nHis O\nfirst O\ncricketing O\nsojurn O\nto O\nIndia B-LOC\nwas O\nas O\na O\nmember O\nof O\nTony B-PER\nGreig I-PER\n's O\nEngland B-LOC\nside O\nin O\n1976-77 O\n. O\n\nHis O\nfather O\nClarence B-PER\nWoolmer I-PER\nrepresented O\nUnited B-LOC\nProvince I-LOC\n, O\nnow O\nrenamed O\nUttar B-LOC\nPradesh I-LOC\n, O\nin O\nIndia B-LOC\n's O\nRanji B-MISC\nTrophy I-MISC\nnational O\nchampionship O\nand O\ncaptained O\nthe O\nstate O\nduring O\n1949 O\n. O\n\nNow O\naged O\n86 O\n, O\nWoolmer B-PER\nsenior O\nlives O\nwith O\nhis O\nson O\nin O\nCape B-LOC\nTown I-LOC\n. O\n\nWoolmer B-PER\n's O\nmemories O\nof O\nKanpur B-LOC\nare O\nfew O\nand O\nblurred O\n. O\n\n\" O\nI O\ndo O\nn't O\nremember O\nmuch O\nof O\nthe O\nplace O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nI O\ncame O\nhere O\non O\nzero O\nand O\nleft O\nat O\nthree O\n( O\naged O\nthree O\n) O\nwhen O\nmy O\nfather O\nwas O\ntransferred O\nto O\nCalcutta B-LOC\nwhere O\nI O\nspent O\nanother O\nfour O\nand O\nhalf O\nyears O\n. O\n\n\" O\nBut O\nI O\ndo O\nremember O\nwe O\nhad O\na O\ncobra O\nsnake O\nin O\nthe O\nbasement O\nof O\nour O\nhouse O\n. O\n\nAlso O\nthat O\nmy O\nfather O\nbought O\na O\nbicycle O\nand O\nwhen O\nwe O\nrode O\nover O\na O\nhose O\npipe O\nit O\nbroke O\ninto O\ntwo O\n. O\n\" O\n\nWoolmer B-PER\nsaid O\nthe O\nhospital O\nwhere O\nhe O\nwas O\nborn O\nis O\nclose O\nto O\nthe O\nstadium O\nwhere O\nthe O\nIndia-South B-MISC\nAfrica I-MISC\ntest O\nwill O\nbe O\nplayed O\n. O\n\n-DOCSTART- O\n\nFREESTYLE O\nSKIING-WORLD B-MISC\nCUP I-MISC\nAERIALS O\nRESULTS O\n. O\n\nTIGNES B-LOC\n, O\nFrance B-LOC\n1996-12-07 O\n\nResults O\nof O\nthe O\nWorld B-MISC\nCup I-MISC\n\nfreestyle O\nskiing O\naerials O\ncompetition O\non O\nSaturday O\n: O\n\nMen O\n: O\n\n1. O\nAlexis B-PER\nBlanc I-PER\n( O\nFrance B-LOC\n) O\n238.36 O\npoints O\n\n2. O\nSebastien B-PER\nFoucras I-PER\n( O\nFrance B-LOC\n) O\n223.60 O\n\n3. O\nJeff B-PER\nBean I-PER\n( O\nCanada B-LOC\n) O\n209.96 O\n\n4. O\nEric B-PER\nBergoust I-PER\n( O\nU.S B-LOC\n) O\n207.15 O\n\n5. O\nChristian B-PER\nRijavec I-PER\n( O\nAustria B-LOC\n) O\n204.17 O\n\n6. O\nAlexandre B-PER\nMikhailov I-PER\n( O\nRussia B-LOC\n) O\n202.59 O\n\n7. O\nAles B-PER\nValenta I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n194.02 O\n\n8. O\nAndy B-PER\nCapicik I-PER\n( O\nCanada B-LOC\n) O\n193.82 O\n\n9. O\nTrace B-PER\nWorthington I-PER\n( O\nU.S. B-LOC\n) O\n192.36 O\n\n10. O\nDmitri B-PER\nDashinski I-PER\nBelarus B-LOC\n) O\n190.70 O\n\nWomen O\n: O\n\n1. O\nVeronica B-PER\nBrenner I-PER\n( O\nCanada B-LOC\n) O\n170.42 O\n\n2. O\nKarin B-PER\nKuster I-PER\n( O\nSwitzerland B-LOC\n) O\n160.55 O\n\n3. O\nEvelyne B-PER\nLeu I-PER\n( O\nSwitzerland B-LOC\n) O\n160.36 O\n\n4. O\nCaroline B-PER\nOlivier I-PER\n( O\nCanada B-LOC\n) O\n157.10 O\n\n5. O\nJacqui B-PER\nCooper I-PER\n( O\nAustralia B-LOC\n) O\n156.52 O\n\n6. O\nMarie B-PER\nLindgren I-PER\n( O\nSweden B-LOC\n) O\n154.82 O\n\n7. O\nDan B-PER\nCuo I-PER\n( O\nChina B-LOC\n) O\n154.61 O\n\n8. O\nKristie B-PER\nMarshall I-PER\n( O\nAustralia B-LOC\n) O\n154.60 O\n\n9. O\nXu B-PER\nNannan I-PER\n( O\nChina B-LOC\n) O\n152.08 O\n\n10. O\nHilde B-PER\nSynnove I-PER\nLid I-PER\n( O\nNorway B-LOC\n) O\n148.20 O\n\n-DOCSTART- O\n\nSKI O\nJUMPING-LEADING O\nWORLD B-MISC\nCUP I-MISC\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nKUUSAMO B-LOC\n, O\nFinland B-LOC\n1996-12-07 O\n\nLeading O\nresults O\nin O\na O\n\nWorld B-MISC\nCup I-MISC\nhigh O\nhill O\n( O\n120-metre O\n) O\nski O\njumping O\nevent O\non O\nSaturday O\n: O\n\n1. O\nTakanobu B-PER\nOkabe I-PER\n( O\nJapan B-LOC\n) O\n303.4 O\npoints O\n( O\nfirst O\njump O\n\n145.4 O\n/ O\nsecond O\njump O\n158 O\n) O\n\n2. O\nKazuyoshi B-PER\nFunaki I-PER\n( O\nJapan B-LOC\n) O\n295.4 O\n( O\n151.5 O\n/ O\n143.9 O\n) O\n\n3. O\nAndreas B-PER\nGoldberger I-PER\n( O\nAustria B-LOC\n) O\n274.4 O\n( O\n144.4 O\n/ O\n130 O\n) O\n\n4. O\nDieter B-PER\nThoma I-PER\n( O\nGermany B-LOC\n) O\n267 O\n( O\n141.6 O\n/ O\n124.4 O\n) O\n\n5. O\nAri-Pekka B-PER\nNikkola I-PER\n( O\nFinland B-LOC\n) O\n256.4 O\n( O\n126 O\n/ O\n130.4 O\n) O\n\n6. O\nReinhard B-PER\nSchwarzenberger I-PER\n( O\nAustria B-LOC\n) O\n252.6 O\n( O\n119.7 O\n/ O\n132.9 O\n) O\n\n7. O\nNoriaki B-PER\nKasai I-PER\n( O\nJapan B-LOC\n) O\n242 O\n( O\n124.2 O\n/ O\n117.8 O\n) O\n\n8. O\nHiroya B-PER\nSaitoh I-PER\n( O\nJapan B-LOC\n) O\n234.7 O\n( O\n124.6 O\n/ O\n110.1 O\n) O\n\n9. O\nJani B-PER\nSoininen I-PER\n( O\nFinland B-LOC\n) O\n231.5 O\n( O\n115 O\n/ O\n116.5 O\n) O\n\n10. O\nKristian B-PER\nBrenden I-PER\n( O\nNorway B-LOC\n) O\n228.1 O\n( O\n129.4 O\n/ O\n98.7 O\n) O\n\nLeading O\nWorld B-MISC\nCup I-MISC\nstandings O\n( O\nafter O\nthree O\nevents O\n) O\n: O\n\n1. O\nThoma B-PER\n210 O\npoints O\n\n2. O\nBrenden B-PER\n206 O\n\n3. O\nGoldberger B-PER\n160 O\n\n4. O\nOkabe B-PER\n146 O\n\n5. O\nFunaki B-PER\n143 O\n\n6. O\nSaitoh B-PER\n121 O\n\n7. O\nEspen B-PER\nBredesen I-PER\n( O\nNorway B-LOC\n) O\n112 O\n\n8. O\nNikkola B-PER\n101 O\n\n9. O\nSoininen B-PER\n85 O\n\n10. O\nPrimoz B-PER\nPeterka I-PER\n( O\nSlovakia B-LOC\n) O\n76 O\n\n-DOCSTART- O\n\nBADMINTON O\n- O\nWORLD B-MISC\nGRAND I-MISC\nPRIX I-MISC\nSEMIFINAL O\nRESULTS O\n. O\n\nTEMBAU B-LOC\nDENPASAR I-LOC\n, O\nBali B-LOC\n1996-12-07 O\n\nResults O\nof O\n\nsemifinals O\nat O\nthe O\nWorld B-MISC\nGrand I-MISC\nPrix I-MISC\nfinals O\non O\nSaturday O\n: O\n\nMen O\n's O\nsingles O\n\nFung B-PER\nPermadi I-PER\n( O\nTaiwan B-LOC\n) O\nbeat O\nIndra B-PER\nWijaya I-PER\n( O\nIndonesia B-LOC\n) O\n15-6 O\n15-8 O\n\nSun B-PER\nJun I-PER\n( O\nChina B-LOC\n) O\nbeat O\nAllan B-PER\nBudi I-PER\nKusuma I-PER\n( O\nIndonesia B-LOC\n) O\n15-9 O\n15-10 O\n\nWomen O\n's O\nsingles O\n\nSusi B-PER\nSusanti I-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\nCamilla B-PER\nMartin I-PER\n( O\nDenmark B-LOC\n) O\n11-1 O\n\n11-3 O\n\nYe B-PER\nZhaoying I-PER\n( O\nChina B-LOC\n) O\nbeat O\nGong B-PER\nZhichao I-PER\n( O\nChina B-LOC\n) O\n11-8 O\n11-3 O\n\n-DOCSTART- O\n\nSPEED O\nSKATING-RESULTS O\nOF O\nWORLD B-MISC\nCUP I-MISC\nSPEED O\nSKATING O\nRACES O\n. O\n\nCHONJU B-LOC\n, O\nSouth B-LOC\nKorea I-LOC\n1996-12-07 O\n\nResults O\non O\nthe O\nfirst O\nday O\nof O\nthe O\nWorld B-MISC\nCup I-MISC\nspeed O\nskating O\nraces O\nhere O\non O\nSaturday O\n. O\n\nMen O\n's O\n500 O\nmetres O\nfirst O\nround O\n: O\n1 O\n. O\n\nHorii B-PER\nManabu I-PER\n( O\nJapan B-LOC\n) O\n37.23 O\nseconds O\n; O\n2 O\n. O\n\nJaegal B-PER\nSung-Yeol I-PER\n( O\nSouth B-LOC\nKorea I-LOC\n) O\n37.46 O\n; O\n3 O\n. O\n\nGrunde B-PER\nNjos I-PER\n( O\nNorway B-LOC\n) O\n37.49 O\n; O\n4 O\n. O\n\nShimizu B-PER\nHiroyasu I-PER\n( O\nJapan B-LOC\n) O\n37.68 O\n; O\n5 O\n. O\n\nSergey B-PER\nKlevchenya I-PER\n( O\nRussia B-LOC\n) O\n37.86 O\n; O\n6 O\n. O\n\nYamakage B-PER\nHiroaki I-PER\n( O\nJapan B-LOC\n) O\n37.93 O\n; O\n7 O\n. O\n\nCasey B-PER\nFitzrandolph I-PER\n( O\nUS B-LOC\n) O\n37.97 O\n; O\n8 O\n. O\n\nSylvain B-PER\nBouchard I-PER\n( O\nCanada B-LOC\n) O\n38.00 O\n; O\n9 O\n. O\n\nKim B-PER\nYoon-man I-PER\n( O\nSouth B-LOC\nKorea I-LOC\n) O\n38.05 O\n; O\n10 O\n. O\n\nInoue B-PER\nJunichi I-PER\n( O\nJapan B-LOC\n) O\n38.08 O\n. O\n\nWomen O\n's O\n500 O\nmetres O\nfirst O\nround O\n: O\n1 O\n. O\n\nXuc B-PER\nRulhong I-PER\n( O\nChina B-LOC\n) O\n40.78 O\n; O\n2 O\n. O\n\nSvetlana B-PER\nJhurova I-PER\n( O\nRussia B-LOC\n) O\n41.08 O\n; O\n3 O\n. O\n\nFranziska B-PER\nSchenk I-PER\n( O\nGermany B-LOC\n) O\n41.13 O\n; O\n4 O\n. O\n\nOkazaki B-PER\nTomomi I-PER\n( O\nJapan B-LOC\n) O\n41.19 O\n; O\n5 O\n. O\n\nShimazaki B-PER\nKyoko I-PER\n( O\nJapan B-LOC\n) O\n41.45 O\n; O\n6 O\n. O\n\nMarianne B-PER\nTimmer I-PER\n( O\nNetherlands B-LOC\n) O\n41.58 O\n; O\n7 O\n. O\n\nJin B-PER\nHua I-PER\n( O\nChina B-LOC\n) O\n41.59 O\n; O\n8 O\n. O\n\nAlena B-PER\nKoroleva I-PER\n( O\nRussia B-LOC\n) O\n41.64 O\n; O\n9 O\n. O\n\nChris B-PER\nWitty I-PER\n( O\nUS B-LOC\n) O\n41.75 O\n; O\n10 O\n. O\n\nAnke B-PER\nBaler I-PER\n( O\nGermany B-LOC\n) O\n41.76 O\n. O\n\nMen O\n's O\n1,000 O\nmetres O\nfirst O\nround O\n: O\n\n1. O\nSylvain B-PER\nBouchard I-PER\n( O\nCanada B-LOC\n) O\n1 O\nminute O\n16.24 O\nseconds O\n\n2. O\nSergey B-PER\nKlevchenya I-PER\n( O\nRussia B-LOC\n) O\n1:16.31 O\n\n3. O\nJan B-PER\nBos I-PER\n( O\nNetherlands B-LOC\n) O\n1:16.38 O\n\n4. O\nGrunde B-PER\nNjos I-PER\n( O\nNorway B-LOC\n) O\n1:16.44 O\n\n5. O\nLee B-PER\nKyou-hyuk I-PER\n( O\nSouth B-LOC\nKorea I-LOC\n) O\n1:16.47 O\n\n6. O\nInoue B-PER\nJunichi I-PER\n( O\nJapan B-LOC\n) O\n1:16.61 O\n\n7. O\nGerard B-PER\nVan I-PER\nVelde I-PER\n( O\nNetherlands B-LOC\n) O\n1:16.63 O\n\n8. O\nKim B-PER\nYoon-man I-PER\n( O\nSouth B-LOC\nKorea I-LOC\n) O\n1:16.75 O\n\n9. O\nJeremy B-PER\nWotherspoon I-PER\n( O\nCanada B-LOC\n) O\n1:16.75 O\n\n10. O\nMiyabe B-PER\nYasunori I-PER\n( O\nJapan B-LOC\n) O\n1:16.86 O\n\nWomen O\n's O\n1,000 O\nmetres O\nfirst O\nround O\n: O\n\n1. O\nFranziska B-PER\nSchenk I-PER\n( O\nGermany B-LOC\n) O\n1:23.17 O\n\n2. O\nKusunose B-PER\nShiho I-PER\n( O\nJapan B-LOC\n) O\n1:24.77 O\n\n3. O\nMarianne B-PER\nTimmer I-PER\n( O\nNetherlands B-LOC\n) O\n1:24.86 O\n\n4. O\nAnka B-PER\nBaier I-PER\n( O\nGermany B-LOC\n) O\n1:25.16 O\n\n5. O\nBecky B-PER\nSundstrom I-PER\n( O\nU.S. B-LOC\n) O\n1:25.39 O\n\n6. O\nShimazaki B-PER\nKyoko I-PER\n( O\nJapan B-LOC\n) O\n1:25.51 O\n\n7. O\nOksana B-PER\nRavllova I-PER\n( O\nRussia B-LOC\n) O\n1:25.55 O\n\n8. O\nSammiya B-PER\nEriko I-PER\n( O\nJapan B-LOC\n) O\n1:25.79 O\n\n9. O\nChris B-PER\nWitty I-PER\n( O\nU.S. B-LOC\n) O\n1:25.85 O\n\n10. O\nXue B-PER\nRulhong I-PER\n( O\nChina B-LOC\n) O\n1:25.89 O\n\n-DOCSTART- O\n\nALPINE O\nSKIING-OFFICIALS O\nHOPE O\nTO O\nSALVAGE O\nWORLD B-MISC\nCUP I-MISC\nWEEKEND O\n. O\n\nWHISTLER B-LOC\n, O\nBritish B-LOC\nColumbia I-LOC\n1996-12-06 O\n\nWorld B-MISC\nCup I-MISC\nski O\nofficials O\nhope O\nto O\nbe O\nable O\nto O\nget O\nin O\nat O\nleast O\none O\nmen O\n's O\ndownhill O\ntraining O\nrun O\non O\nSaturday O\nin O\nan O\neffort O\nto O\nsalvage O\nthe O\nweekend O\nracing O\nprogramme O\n. O\n\nFor O\nthe O\nthird O\nconsecutive O\nday O\n, O\nFriday O\n's O\nscheduled O\ntraining O\nruns O\nwere O\ncancelled O\ndue O\nto O\nheavy O\nwet O\nsnow O\nand O\nfog O\non O\nWhistler B-LOC\nMountain I-LOC\n, O\nleaving O\nthe O\nscheduled O\nWorld B-MISC\nCup I-MISC\nevents O\nin O\njeopardy O\n. O\n\nRules O\ncall O\nfor O\nat O\nleast O\none O\ntraining O\nrun O\nto O\nbe O\ncompleted O\nbefore O\na O\nWorld B-MISC\nCup I-MISC\ndownhill O\nrace O\ncan O\nbe O\nstaged O\n. O\n\nOrganisers O\nhope O\nto O\nget O\nthat O\nrun O\nin O\non O\nSaturday O\nmorning O\n, O\nconditions O\npermitting O\n, O\nand O\nstage O\nthe O\nrace O\nlater O\nin O\nthe O\nday O\nor O\non O\nSunday O\n. O\n\n\" O\nThere O\nwas O\nno O\npossibility O\ntoday O\nto O\nmake O\na O\ntraining O\nrun O\n, O\n\" O\nsaid O\nBernd B-PER\nZobel I-PER\n, O\nthe O\nCanadian B-MISC\nmen O\n's O\nnational O\ncoach O\n, O\nciting O\ntoo O\nmuch O\nnew O\nsnow O\nand O\npoor O\nvisibility O\n. O\n\nIf O\norganisers O\nare O\nforced O\nto O\nrun O\nthe O\ndownhill O\non O\nSunday O\n, O\nthe O\nsuper-giant O\nslalom O\noriginally O\nscheduled O\nfor O\nSunday O\nwould O\nlikely O\nbe O\nabandoned O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nLEADING O\nSCOTTISH B-MISC\nPREMIER I-MISC\nDIVISION I-MISC\nSCORERS O\n. O\n\nGLASGOW B-LOC\n1996-12-07 O\n\nLeading O\ngoalscorers O\nin O\nthe O\n\nScottish B-MISC\npremier I-MISC\ndivision O\nafter O\nSaturday O\n's O\nmatches O\n: O\n\n10 O\n- O\nBilly B-PER\nDodds I-PER\n( O\nAberdeen B-ORG\n) O\n, O\nPierre B-PER\nVan I-PER\nHooydonk I-PER\n( O\nCeltic B-ORG\n) O\n\n9 O\n- O\nPaul B-PER\nGascoigne I-PER\n( O\nRangers B-ORG\n) O\n\n7 O\n- O\nPaul B-PER\nWright I-PER\n( O\nKilmarnock B-ORG\n) O\n, O\nAlly B-PER\nMcCoist I-PER\n( O\nRangers B-ORG\n) O\n\n6 O\n- O\nAndreas B-PER\nThom I-PER\n( O\nCeltic B-ORG\n) O\n, O\nDean B-PER\nWindass I-PER\n( O\nAberdeen B-ORG\n) O\n, O\n\nBrian B-PER\nLaudrup I-PER\n( O\nRangers B-ORG\n) O\n, O\nDarren B-PER\nJackson I-PER\n\n( O\nHibernian B-ORG\n) O\n\n5 O\n- O\nPeter B-PER\nvan I-PER\nVossen I-PER\n( O\nRangers B-ORG\n) O\n, O\nGerry B-PER\nBritton I-PER\n\n( O\nDunfermline B-ORG\n) O\n, O\nColin B-PER\nCameron I-PER\n( O\nHearts B-ORG\n) O\n, O\nRobert B-PER\n\nWinters B-PER\n( O\nDundee B-ORG\nUnited I-ORG\n) O\n, O\nPaolo B-PER\nDi I-PER\nCanio I-PER\n( O\nCeltic B-ORG\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nLEADING O\nENGLISH B-MISC\nGOALSCORERS O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nLeading O\ngoalscorers O\nin O\nthe O\nEnglish B-MISC\n\npremier O\nleague O\nafter O\nSaturday O\n's O\nmatches O\n: O\n\n13 O\n- O\nIan B-PER\nWright I-PER\n( O\nArsenal B-ORG\n) O\n\n9 O\n- O\nFabrizio B-PER\nRavanelli I-PER\n( O\nMiddlesbrough B-ORG\n) O\n, O\nAlan B-PER\nShearer I-PER\n\n( O\nNewcastle B-ORG\n) O\n\n8 O\n- O\nMatthew B-PER\nLe I-PER\nTissier I-PER\n( O\nSouthampton B-ORG\n) O\n, O\nDwight B-PER\nYorke I-PER\n( O\nAston B-ORG\n\nVilla B-ORG\n) O\n, O\nLes B-PER\nFerdinand I-PER\n( O\nNewcastle B-ORG\n) O\n, O\nEfan B-PER\nEkoku I-PER\n( O\nWimbledon B-LOC\n) O\n, O\n\nGianluca B-PER\nVialli I-PER\n( O\nChelsea B-ORG\n) O\n\n7 O\n- O\nRobbie B-PER\nEarle I-PER\n( O\nWimbledon B-LOC\n) O\n, O\nLes B-PER\nFerdinand I-PER\n( O\nNewcastle B-ORG\n) O\n\n6 O\n- O\nMarcus B-PER\nGayle I-PER\n( O\nWimbledon B-LOC\n) O\n, O\nGary B-PER\nSpeed I-PER\n( O\nEverton B-ORG\n) O\n, O\nChris B-PER\n\nSutton B-PER\n( O\nBlackburn B-ORG\n) O\n\n5 O\n- O\nRobbie B-PER\nFowler I-PER\n( O\nLiverpool B-ORG\n) O\n, O\nSteve B-PER\nMcManaman I-PER\n( O\nLiverpool B-ORG\n) O\n\n4 O\n- O\nPeter B-PER\nBeardsley I-PER\n( O\nNewcastle B-ORG\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nNORTHERN B-LOC\nIRELAND I-LOC\nPREMIER O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nResults O\nof O\nNorthern B-LOC\nIreland I-LOC\npremier O\n\ndivision O\nmatches O\non O\nSaturday O\n: O\n\nArds B-ORG\n0 O\nCrusaders B-ORG\n0 O\n\nCliftonville B-ORG\n1 O\nPortadown B-ORG\n1 O\n\nGlenavon B-ORG\n2 O\nLinfield B-ORG\n1 O\n\nGlentoran B-ORG\n1 O\nColeraine B-ORG\n0 O\n\nStandings O\n( O\ntabulated O\n- O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\n\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nColeraine B-ORG\n10 O\n7 O\n1 O\n2 O\n18 O\n11 O\n22 O\n\nLinfield B-ORG\n10 O\n4 O\n3 O\n3 O\n13 O\n10 O\n15 O\n\nCrusaders B-ORG\n10 O\n3 O\n4 O\n3 O\n11 O\n9 O\n13 O\n\nGlenavon B-ORG\n10 O\n3 O\n4 O\n3 O\n15 O\n14 O\n13 O\n\nGlentoran B-ORG\n10 O\n3 O\n3 O\n4 O\n18 O\n18 O\n12 O\n\nPortadown B-ORG\n9 O\n3 O\n3 O\n3 O\n11 O\n12 O\n12 O\n\nArds B-ORG\n10 O\n3 O\n2 O\n5 O\n12 O\n17 O\n11 O\n\nCliftonville B-ORG\n9 O\n1 O\n4 O\n4 O\n5 O\n12 O\n7 O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nBRITISH O\nRESULTS O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nResults O\nof O\nBritish B-MISC\nrugby O\nunion O\n\nmatches O\non O\nSaturday O\n: O\n\nPilkington B-MISC\nCup I-MISC\nfourth O\nround O\n\nReading B-ORG\n50 O\nWidnes B-ORG\n3 O\n\nEnglish B-MISC\ndivision O\none O\n\nBath B-ORG\n35 O\nHarlequins B-ORG\n20 O\n\nGloucester B-ORG\n29 O\nLondon B-ORG\nIrish I-ORG\n19 O\n\nOrrell B-ORG\n22 O\nWest B-ORG\nHartlepool I-ORG\n15 O\n\nWasps B-ORG\n15 O\nBristol B-ORG\n13 O\n\nWelsh B-MISC\ndivision O\none O\n\nCaerphilly B-ORG\n20 O\nCardiff B-ORG\n34 O\n\nLlanelli B-ORG\n97 O\nNewbridge B-ORG\n10 O\n\nNewport B-ORG\n45 O\nDunvant B-ORG\n22 O\n\nPontypridd B-ORG\n53 O\nBridgend B-ORG\n9 O\n\nSwansea B-ORG\n49 O\nNeath B-ORG\n10 O\n\nTreorchy B-ORG\n13 O\nEbbw B-ORG\nVale I-ORG\n17 O\n\nScottish B-MISC\ndivision O\none O\n\nBoroughmuir B-ORG\n31 O\nWatsonians B-ORG\n35 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSCOTTISH B-MISC\nPREMIER O\nDIVISION O\nSUMMARIES O\n. O\n\nGLASGOW B-LOC\n1996-12-07 O\n\nSummaries O\nof O\nScottish B-MISC\npremier O\ndivision O\nmatches O\nplayed O\non O\nSaturday O\n: O\n\nDunfermline B-ORG\n2 O\n( O\nMillar B-PER\n43 O\n, O\n46 O\npenalty O\n) O\nAberdeen B-ORG\n3 O\n( O\nMiller B-PER\n10 O\n, O\nRowson B-PER\n55 O\n, O\nWindass O\n78 O\n) O\n. O\n\nHalftime O\n1-1 O\n. O\n\nAttendance O\n: O\n5,465 O\n\nHearts B-ORG\n0 O\nRaith B-ORG\n0 O\n. O\n\n10,719 O\n\nKilmarnock B-ORG\n0 O\nDundee B-ORG\nUnited I-ORG\n2 O\n( O\nOlafsson B-PER\n22 O\n, O\n51 O\n) O\n. O\n\n0-1 O\n. O\n\n5,812 O\n\nMotherwell B-ORG\n2 O\n( O\nDavies B-PER\n39 O\n, O\nRoss B-PER\n89 O\n) O\nCeltic B-ORG\n1 O\n( O\nHay B-PER\n83 O\n) O\n. O\n\n1-0 O\n. O\n\n11,589 O\n\nRangers B-ORG\n4 O\n( O\nFerguson B-PER\n34 O\n, O\nMcCoist B-PER\n71 O\n74 O\n, O\nLaudrup B-PER\n83 O\n) O\nHibernian B-ORG\n3 O\n( O\nWright B-PER\n21 O\n, O\nJackson B-PER\n41 O\n, O\nMcGinlay B-PER\n86 O\n) O\n. O\n\n1-2 O\n. O\n\n48,053 O\n. O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nRETIRING O\nCAMPESE B-PER\nWEIGHS O\nUP O\nOPTIONS O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nDavid B-PER\nCampese I-PER\nwill O\nconsider O\noffers O\nto O\nplay O\nclub O\nrugby O\nin O\nEngland B-LOC\nbut O\nlooks O\nmore O\nlikely O\nto O\nspend O\nthe O\nnext O\nyear O\nchasing O\nbusiness O\nopportunities O\nin O\nAustralia B-LOC\n. O\n\nThe O\n34-year-old O\nwinger O\nplayed O\nhis O\nfinal O\ngame O\nin O\na O\nWallaby B-ORG\njersey O\non O\nSaturday O\nbut O\nis O\ncurrently O\na O\ntarget O\nfor O\nclubs O\neager O\nto O\nmatch O\nLondon B-LOC\nside O\nSaracens B-ORG\nwho O\nhave O\nalready O\nsnapped O\nup O\nFrancois B-PER\nPienaar I-PER\n, O\nMichael B-PER\nLynagh I-PER\nand O\nPhilippe B-PER\nSella I-PER\n. O\n\n\" O\nIf O\nthe O\nopportunity O\nis O\nthere O\nI O\n'd O\nobviously O\nthink O\nabout O\nit O\nbut O\nthe O\nthing O\nthat O\nholds O\nme O\nback O\nis O\nbusiness O\n, O\n\" O\nsaid O\nCampese B-PER\n. O\n\n\" O\nI O\n'd O\nlike O\nto O\ncome O\nover O\nbut O\nthere O\nare O\na O\nlot O\nof O\nthings O\nhappening O\nat O\nhome O\n. O\n\nI O\n've O\nalso O\ngot O\na O\ncontract O\nto O\nplay O\nfor O\nNew B-ORG\nSouth I-ORG\nWales I-ORG\nin O\nthe O\nSuper O\n12 O\nnext O\nyear O\n. O\n\" O\n\nFormer O\nWallaby B-ORG\ncaptain O\nNick B-PER\nFarr-Jones I-PER\nbelieves O\nCampese B-PER\nmay O\nyet O\nbe O\ntempted O\nto O\nEngland B-LOC\n. O\n\n\" O\nI O\n'm O\nsure O\nthere O\nare O\na O\nfew O\npeople O\nin O\nEngland B-LOC\nwho O\n'd O\nbe O\ndelighted O\nto O\nhave O\nDavid B-PER\nCampese I-PER\nin O\ntheir O\nclub O\n's O\njersey O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nPREMIER O\nLEAGUE O\nSUMMARIES O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nSummaries O\nof O\nEnglish B-MISC\npremier O\n\nlealgue O\nmatches O\non O\nSaturday O\n: O\n\nArsenal B-ORG\n2 O\n( O\nAdams B-PER\n45 O\n, O\nVieira B-PER\n90 O\n) O\nDerby B-ORG\n2 O\n( O\nSturridge B-PER\n62 O\n, O\nPowell B-PER\n\n71 O\n) O\n. O\n\nHalftime O\n1-0 O\n. O\n\nAttendance O\n: O\n38,018 O\n\nChelsea B-ORG\n2 O\n( O\nZola B-PER\n12 O\n, O\nVialli B-PER\n55 O\n) O\nEverton B-ORG\n2 O\n( O\nBranch B-PER\n17 O\n, O\n\nKanchelskis B-PER\n28 O\n) O\n. O\n\n1-2 O\n. O\n\n28,418 O\n\nCoventry B-ORG\n1 O\n( O\nWhelan B-PER\n60 O\n) O\nTottenham B-ORG\n2 O\n( O\nSheringham B-PER\n27 O\n, O\nSinton B-PER\n75 O\n) O\n. O\n\n0-1 O\n. O\n\n19,675 O\n\nLeicester B-ORG\n1 O\n( O\nMarshall B-PER\n78 O\n) O\nBlackburn B-ORG\n1 O\n( O\nSutton B-PER\n34 O\n) O\n. O\n\n0-1 O\n. O\n\n19,306 O\n\nLiverpool B-ORG\n0 O\nSheffield B-ORG\nWednesday I-ORG\n1 O\n( O\nWhittingham B-PER\n22 O\n) O\n. O\n\n0-1 O\n. O\n\n39,507 O\n\nMiddlesbrough B-ORG\n0 O\nLeeds B-ORG\n0 O\n. O\n\n30,018 O\n\nSouthampton B-ORG\n0 O\nAston B-ORG\nVilla I-ORG\n1 O\n( O\nTownsend B-PER\n34 O\n) O\n. O\n\n0-1 O\n. O\n\n15,232 O\n\nSunderland B-ORG\n1 O\n( O\nMelville B-PER\n83 O\n) O\nWimbledon B-LOC\n3 O\n( O\nEkoku B-PER\n8 O\n, O\n29 O\n, O\nHoldsworth B-PER\n\n89 O\n) O\n. O\n\n0-2 O\n. O\n\n19,672 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSCOTTISH B-MISC\nLEAGUE O\nSTANDINGS O\n. O\n\nGLASGOW B-LOC\n1996-12-07 O\n\nScottish B-MISC\nleague O\nstandings O\nafter O\n\nSaturday O\n's O\nmatches O\n( O\ntabulated O\n- O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nPremier O\ndivision O\n\nRangers B-ORG\n14 O\n11 O\n2 O\n1 O\n35 O\n12 O\n35 O\n\nCeltic B-ORG\n14 O\n8 O\n3 O\n3 O\n32 O\n15 O\n27 O\n\nAberdeen B-ORG\n15 O\n7 O\n4 O\n4 O\n28 O\n19 O\n25 O\n\nHearts B-ORG\n15 O\n5 O\n6 O\n4 O\n18 O\n19 O\n21 O\n\nHibernian B-ORG\n15 O\n5 O\n3 O\n7 O\n16 O\n25 O\n18 O\n\nDundee B-ORG\nUnited I-ORG\n15 O\n4 O\n5 O\n6 O\n17 O\n17 O\n17 O\n\nMotherwell B-ORG\n15 O\n4 O\n5 O\n6 O\n17 O\n23 O\n17 O\n\nDunfermline B-ORG\n14 O\n4 O\n5 O\n5 O\n19 O\n27 O\n17 O\n\nRaith B-ORG\n15 O\n3 O\n3 O\n9 O\n14 O\n27 O\n12 O\n\nKilmarnock B-ORG\n14 O\n3 O\n2 O\n9 O\n17 O\n29 O\n11 O\n\nDivision O\nOne O\n\nSt B-ORG\nJohnstone I-ORG\n17 O\n12 O\n2 O\n3 O\n36 O\n8 O\n38 O\n\nFalkirk B-ORG\n17 O\n9 O\n2 O\n6 O\n18 O\n15 O\n29 O\n\nAirdrieonians B-ORG\n16 O\n6 O\n8 O\n2 O\n26 O\n16 O\n26 O\n\nDundee B-ORG\n16 O\n7 O\n5 O\n4 O\n12 O\n8 O\n26 O\n\nPartick B-ORG\n16 O\n6 O\n6 O\n4 O\n23 O\n16 O\n24 O\n\nSt B-ORG\nMirren I-ORG\n16 O\n7 O\n2 O\n7 O\n22 O\n21 O\n23 O\n\nGreenock B-ORG\nMorton I-ORG\n16 O\n6 O\n4 O\n6 O\n17 O\n16 O\n22 O\n\nClydebank B-ORG\n16 O\n4 O\n2 O\n10 O\n11 O\n25 O\n14 O\n\nStirling B-ORG\n16 O\n3 O\n3 O\n10 O\n18 O\n33 O\n12 O\n\nEast B-ORG\nFife I-ORG\n14 O\n1 O\n4 O\n9 O\n10 O\n35 O\n7 O\n\nDivision O\nTwo O\n\nAyr B-ORG\n16 O\n11 O\n2 O\n3 O\n30 O\n18 O\n35 O\n\nLivingston B-ORG\n16 O\n10 O\n4 O\n2 O\n27 O\n13 O\n34 O\n\nHamilton B-ORG\n15 O\n9 O\n4 O\n2 O\n31 O\n11 O\n31 O\n\nClyde B-ORG\n15 O\n6 O\n4 O\n5 O\n21 O\n20 O\n22 O\n\nQueen B-ORG\nof I-ORG\nSouth I-ORG\n16 O\n6 O\n4 O\n6 O\n24 O\n27 O\n22 O\n\nStenhousemuir B-ORG\n15 O\n4 O\n5 O\n6 O\n18 O\n12 O\n17 O\n\nStranraer B-ORG\n15 O\n5 O\n2 O\n8 O\n13 O\n21 O\n17 O\n\nDumbarton B-ORG\n16 O\n4 O\n4 O\n8 O\n18 O\n29 O\n16 O\n\nBrechin B-ORG\n16 O\n3 O\n6 O\n7 O\n14 O\n20 O\n15 O\n\nBerwick B-ORG\n16 O\n1 O\n3 O\n12 O\n16 O\n41 O\n6 O\n\nDivision O\nThree O\n\nMontrose B-ORG\n17 O\n9 O\n3 O\n5 O\n30 O\n25 O\n30 O\n\nInverness B-ORG\nThistle I-ORG\n16 O\n8 O\n5 O\n3 O\n28 O\n20 O\n29 O\n\nRoss B-ORG\nCounty I-ORG\n17 O\n8 O\n3 O\n6 O\n27 O\n23 O\n27 O\n\nAlloa B-ORG\n16 O\n7 O\n4 O\n5 O\n24 O\n21 O\n25 O\n\nCowdenbeath B-ORG\n15 O\n7 O\n3 O\n5 O\n22 O\n16 O\n24 O\n\nAlbion B-ORG\n16 O\n6 O\n6 O\n4 O\n21 O\n17 O\n24 O\n\nForfar B-ORG\n15 O\n6 O\n4 O\n5 O\n26 O\n24 O\n22 O\n\nQueen B-ORG\n's I-ORG\nPark I-ORG\n16 O\n3 O\n5 O\n8 O\n20 O\n30 O\n14 O\n\nArbroath B-ORG\n16 O\n2 O\n6 O\n8 O\n12 O\n23 O\n12 O\n\nEast B-ORG\nStirling I-ORG\n16 O\n2 O\n5 O\n9 O\n14 O\n25 O\n11 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nLEAGUE O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nStandings O\nin O\nEnglish B-MISC\nleague O\nsoccer O\n\nafter O\nSaturday O\n's O\nmatches O\n( O\ntabulated O\n- O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\n\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nPremier B-MISC\nleague I-MISC\n\nArsenal B-ORG\n17 O\n10 O\n5 O\n2 O\n34 O\n16 O\n35 O\n\nWimbledon B-ORG\n16 O\n9 O\n4 O\n3 O\n29 O\n17 O\n31 O\n\nLiverpool B-ORG\n16 O\n9 O\n4 O\n3 O\n26 O\n14 O\n31 O\n\nAston B-ORG\nVilla I-ORG\n17 O\n9 O\n3 O\n5 O\n22 O\n15 O\n30 O\n\nNewcastle B-ORG\n15 O\n9 O\n2 O\n4 O\n26 O\n17 O\n29 O\n\nManchester B-ORG\nUnited I-ORG\n15 O\n7 O\n5 O\n3 O\n29 O\n22 O\n26 O\n\nChelsea B-ORG\n16 O\n6 O\n7 O\n3 O\n25 O\n23 O\n25 O\n\nEverton B-ORG\n16 O\n6 O\n6 O\n4 O\n25 O\n20 O\n24 O\n\nSheffield B-ORG\nWednesday I-ORG\n16 O\n6 O\n6 O\n4 O\n17 O\n18 O\n24 O\n\nTottenham B-ORG\n16 O\n7 O\n2 O\n7 O\n17 O\n17 O\n23 O\n\nDerby B-ORG\n16 O\n5 O\n7 O\n4 O\n19 O\n19 O\n22 O\n\nLeicester B-ORG\n17 O\n6 O\n3 O\n8 O\n17 O\n22 O\n21 O\n\nLeeds B-ORG\n16 O\n6 O\n2 O\n8 O\n15 O\n20 O\n20 O\n\nSunderland B-ORG\n16 O\n4 O\n5 O\n7 O\n14 O\n21 O\n17 O\n\nWest B-ORG\nHam I-ORG\n16 O\n4 O\n5 O\n7 O\n13 O\n20 O\n17 O\n\nMiddlesbrough B-ORG\n17 O\n3 O\n6 O\n8 O\n20 O\n28 O\n15 O\n\nBlackburn B-ORG\n16 O\n2 O\n7 O\n7 O\n16 O\n21 O\n13 O\n\nSouthampton B-ORG\n17 O\n3 O\n4 O\n10 O\n24 O\n32 O\n13 O\n\nCoventry B-ORG\n16 O\n1 O\n7 O\n8 O\n10 O\n23 O\n10 O\n\nNottingham B-ORG\nForest I-ORG\n15 O\n1 O\n6 O\n8 O\n12 O\n25 O\n9 O\n\nDivision O\nOne O\n\nBolton B-ORG\n21 O\n11 O\n8 O\n2 O\n43 O\n28 O\n41 O\n\nSheffield B-ORG\nUnited I-ORG\n21 O\n11 O\n6 O\n4 O\n38 O\n20 O\n39 O\n\nBarnsley B-ORG\n21 O\n10 O\n8 O\n3 O\n38 O\n26 O\n38 O\n\nCrystal B-ORG\nPalace I-ORG\n21 O\n9 O\n8 O\n4 O\n46 O\n22 O\n35 O\n\nWolverhampton B-ORG\n21 O\n9 O\n6 O\n6 O\n29 O\n21 O\n33 O\n\nTranmere B-ORG\n22 O\n9 O\n5 O\n8 O\n31 O\n26 O\n32 O\n\nNorwich B-ORG\n20 O\n9 O\n5 O\n6 O\n27 O\n21 O\n32 O\n\nBirmingham B-ORG\n22 O\n8 O\n8 O\n6 O\n23 O\n21 O\n32 O\n\nOxford B-LOC\n22 O\n8 O\n6 O\n8 O\n27 O\n21 O\n30 O\n\nStoke B-ORG\n20 O\n8 O\n6 O\n6 O\n27 O\n30 O\n30 O\n\nSwindon B-ORG\n22 O\n9 O\n2 O\n11 O\n32 O\n28 O\n29 O\n\nCharlton B-ORG\n21 O\n9 O\n2 O\n10 O\n23 O\n29 O\n29 O\n\nHuddersfield B-ORG\n22 O\n7 O\n7 O\n8 O\n25 O\n28 O\n28 O\n\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\n22 O\n7 O\n7 O\n8 O\n25 O\n28 O\n28 O\n\nPort B-ORG\nVale I-ORG\n22 O\n6 O\n10 O\n6 O\n19 O\n22 O\n28 O\n\nIpswich B-ORG\n22 O\n6 O\n8 O\n8 O\n27 O\n32 O\n26 O\n\nManchester B-ORG\nCity I-ORG\n22 O\n8 O\n2 O\n12 O\n26 O\n35 O\n26 O\n\nPortsmouth B-LOC\n22 O\n7 O\n5 O\n10 O\n25 O\n29 O\n26 O\n\nReading B-ORG\n22 O\n7 O\n5 O\n10 O\n25 O\n33 O\n26 O\n\nWest B-ORG\nBromwich I-ORG\n20 O\n5 O\n9 O\n6 O\n26 O\n31 O\n24 O\n\nSouthend B-ORG\n22 O\n5 O\n9 O\n8 O\n23 O\n36 O\n24 O\n\nGrimsby B-ORG\n22 O\n5 O\n6 O\n11 O\n24 O\n41 O\n21 O\n\nBradford B-ORG\n22 O\n5 O\n6 O\n11 O\n21 O\n37 O\n21 O\n\nOldham B-ORG\n22 O\n4 O\n8 O\n10 O\n23 O\n28 O\n20 O\n\nDivision O\nTwo O\n\nBrentford B-ORG\n22 O\n11 O\n7 O\n4 O\n35 O\n23 O\n40 O\n\nMillwall B-ORG\n22 O\n11 O\n7 O\n4 O\n32 O\n22 O\n40 O\n\nBury B-ORG\n21 O\n11 O\n6 O\n4 O\n33 O\n20 O\n39 O\n\nLuton B-ORG\n21 O\n11 O\n4 O\n6 O\n34 O\n25 O\n37 O\n\nBurnley B-ORG\n22 O\n11 O\n4 O\n7 O\n30 O\n22 O\n37 O\n\nChesterfield B-ORG\n21 O\n11 O\n4 O\n6 O\n22 O\n16 O\n37 O\n\nStockport B-ORG\n22 O\n10 O\n6 O\n6 O\n29 O\n25 O\n36 O\n\nWatford B-ORG\n21 O\n9 O\n9 O\n3 O\n24 O\n18 O\n36 O\n\nWrexham B-ORG\n20 O\n9 O\n8 O\n3 O\n27 O\n22 O\n35 O\n\nCrewe B-ORG\n21 O\n11 O\n1 O\n9 O\n29 O\n21 O\n34 O\n\nBristol B-ORG\nCity I-ORG\n21 O\n9 O\n6 O\n6 O\n36 O\n23 O\n33 O\n\nBristol B-ORG\nRovers I-ORG\n22 O\n7 O\n7 O\n8 O\n22 O\n23 O\n28 O\n\nShrewsbury B-ORG\n22 O\n7 O\n6 O\n9 O\n26 O\n33 O\n27 O\n\nYork B-ORG\n21 O\n7 O\n5 O\n9 O\n23 O\n29 O\n26 O\n\nBlackpool B-ORG\n22 O\n5 O\n10 O\n7 O\n22 O\n24 O\n25 O\n\nWalsall B-ORG\n21 O\n7 O\n4 O\n10 O\n21 O\n25 O\n25 O\n\nGillingham B-ORG\n22 O\n7 O\n4 O\n11 O\n21 O\n27 O\n25 O\n\nPreston B-ORG\n22 O\n7 O\n4 O\n11 O\n21 O\n27 O\n25 O\n\nBournemouth B-ORG\n22 O\n7 O\n4 O\n11 O\n20 O\n27 O\n25 O\n\nPlymouth B-ORG\n22 O\n5 O\n8 O\n9 O\n24 O\n31 O\n23 O\n\nPeterborough B-ORG\n22 O\n4 O\n8 O\n10 O\n32 O\n41 O\n20 O\n\nNotts B-ORG\nCounty I-ORG\n21 O\n5 O\n5 O\n11 O\n15 O\n23 O\n20 O\n\nWycombe B-ORG\n22 O\n4 O\n5 O\n13 O\n17 O\n33 O\n17 O\n\nRotherham B-ORG\n21 O\n3 O\n6 O\n12 O\n18 O\n33 O\n15 O\n\nDivision O\nThree O\n\nFulham B-ORG\n22 O\n15 O\n3 O\n4 O\n36 O\n16 O\n48 O\n\nCambridge B-ORG\n22 O\n13 O\n3 O\n6 O\n33 O\n27 O\n42 O\n\nWigan B-ORG\n21 O\n12 O\n4 O\n5 O\n39 O\n24 O\n40 O\n\nCarlisle B-ORG\n22 O\n11 O\n7 O\n4 O\n32 O\n20 O\n40 O\n\nCardiff B-ORG\n21 O\n10 O\n4 O\n7 O\n25 O\n22 O\n34 O\n\nSwansea B-ORG\n22 O\n9 O\n5 O\n8 O\n25 O\n25 O\n32 O\n\nBarnet B-ORG\n22 O\n8 O\n8 O\n6 O\n23 O\n17 O\n32 O\n\nColchester B-ORG\n22 O\n7 O\n10 O\n5 O\n32 O\n26 O\n31 O\n\nScunthorpe B-ORG\n22 O\n9 O\n4 O\n9 O\n28 O\n30 O\n31 O\n\nNorthampton B-ORG\n22 O\n8 O\n6 O\n8 O\n31 O\n26 O\n30 O\n\nScarborough B-ORG\n21 O\n7 O\n9 O\n5 O\n30 O\n27 O\n30 O\n\nLincoln B-ORG\n22 O\n8 O\n6 O\n8 O\n28 O\n33 O\n30 O\n\nChester B-ORG\n21 O\n8 O\n6 O\n7 O\n23 O\n23 O\n30 O\n\nHull B-ORG\n22 O\n6 O\n11 O\n5 O\n20 O\n22 O\n29 O\n\nTorquay B-ORG\n22 O\n8 O\n4 O\n10 O\n22 O\n24 O\n28 O\n\nRochdale B-ORG\n21 O\n6 O\n8 O\n7 O\n27 O\n26 O\n26 O\n\nExeter B-ORG\n22 O\n7 O\n5 O\n10 O\n21 O\n28 O\n26 O\n\nDoncaster B-ORG\n22 O\n7 O\n3 O\n12 O\n24 O\n33 O\n24 O\n\nMansfield B-ORG\n21 O\n5 O\n9 O\n7 O\n21 O\n22 O\n24 O\n\nLeyton B-ORG\nOrient I-ORG\n21 O\n6 O\n6 O\n9 O\n16 O\n19 O\n24 O\n\nHereford B-ORG\n22 O\n6 O\n5 O\n11 O\n23 O\n31 O\n23 O\n\nDarlington B-ORG\n22 O\n6 O\n4 O\n12 O\n30 O\n39 O\n22 O\n\nHartlepool B-ORG\n21 O\n6 O\n4 O\n11 O\n23 O\n28 O\n22 O\n\nBrighton B-ORG\n22 O\n3 O\n4 O\n15 O\n18 O\n42 O\n13 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nVIEIRA B-PER\nSAVES O\nARSENAL B-ORG\nWITH O\nLAST-MINUTE O\nEQUALISER O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nFrenchman B-MISC\nPatrick B-PER\nVieira I-PER\nblasted O\na O\nlast-minute O\ngoal O\nto O\nsalvage O\na O\n2-2 O\ndraw O\nfor O\nEnglish B-MISC\npremier O\nleague O\nleaders O\nArsenal B-ORG\nat O\nhome O\nto O\nDerby B-ORG\non O\nSaturday O\n. O\n\nThe O\nLondon B-LOC\nclub O\nhad O\nbeen O\nrocked O\nby O\na O\ntwo-goal O\nburst O\nfrom O\nforwards O\nDean B-PER\nSturridge I-PER\nand O\nDarryl B-PER\nPowell I-PER\nin O\nthe O\n62nd O\nand O\n71st O\nminutes O\nwhich O\noverturned O\nArsenal B-ORG\n's O\n1-0 O\nlead O\nfrom O\na O\ndiving O\nheader O\nby O\ncaptain O\nTony B-PER\nAdams I-PER\non O\nthe O\nstroke O\nof O\nhalftime O\n. O\n\nLiverpool B-ORG\nsuffered O\nan O\nupset O\nfirst O\nhome O\nleague O\ndefeat O\nof O\nthe O\nseason O\n, O\nbeaten O\n1-0 O\nby O\na O\nGuy B-PER\nWhittingham I-PER\ngoal O\nfor O\nSheffield B-ORG\nWednesday I-ORG\n. O\n\nWimbledon B-ORG\nleap-frogged O\nover O\nLiverpool B-ORG\ninto O\nsecond O\nplace O\nby O\nwinning O\n3-1 O\nat O\nSunderland B-ORG\nto O\nextend O\ntheir O\nunbeaten O\nleague O\nand O\ncup O\nrun O\nto O\n18 O\ngames O\n. O\n\nTwo O\nstrikes O\nby O\nEfan B-PER\nEkoku I-PER\nin O\nthe O\nfirst O\nhalf O\nand O\na O\nlate O\ngoal O\nfrom O\nfellow O\nforward O\nDean B-PER\nHoldsworth I-PER\nsecured O\nvictory O\nfor O\nWimbledon B-ORG\n, O\nwho O\ntrail O\npacemakers O\nArsenal B-ORG\nby O\nfour O\npoints O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSCOTTISH B-MISC\nLEAGUE O\nAND O\nCUP O\nRESULTS O\n. O\n\nGLASGOW B-LOC\n1996-12-07 O\n\nResults O\nof O\nScottish B-MISC\nleague O\nand O\ncup O\n\nmatches O\nplayed O\non O\nSaturday O\n: O\n\nPremier O\ndivision O\n\nDunfermline B-ORG\n2 O\nAberdeen B-ORG\n3 O\n\nHearts B-ORG\n0 O\nRaith B-ORG\n0 O\n\nKilmarnock B-ORG\n0 O\nDundee B-ORG\nUnited I-ORG\n2 O\n\nMotherwell B-ORG\n2 O\nCeltic B-ORG\n1 O\n\nRangers B-ORG\n4 O\nHibernian B-ORG\n3 O\n\nDivision O\none O\n\nDundee B-ORG\n2 O\nFalkirk B-ORG\n0 O\n\nGreenock B-ORG\nMorton I-ORG\n0 O\nSt B-ORG\nJohnstone I-ORG\n2 O\n\nPostponed O\n: O\nAirdrieonians B-ORG\nv O\nClydebank B-ORG\n( O\nto O\nWednesday O\n) O\n, O\nEast B-ORG\n\nFife B-ORG\nv O\nPartick B-ORG\n, O\nStirling B-ORG\nv O\nSt B-ORG\nMirren I-ORG\n( O\nto O\nTuesday O\n) O\n\nDivision O\ntwo O\n\nLivingston B-ORG\n2 O\nStenhousemuir B-ORG\n1 O\n\nStranraer B-ORG\n0 O\nBrechin B-ORG\n1 O\n\nDivision O\nthree O\n\nRoss B-ORG\nCounty I-ORG\n4 O\nMontrose B-ORG\n4 O\n\nPostponed O\n: O\nForfar B-ORG\nv O\nAlloa B-ORG\n, O\nInverness B-ORG\nThistle I-ORG\nv O\nQueen B-ORG\n's I-ORG\nPark I-ORG\n\nScottish B-MISC\nCup I-MISC\nfirst O\nround O\n\nAlloa B-ORG\n3 O\nHawick B-ORG\n1 O\n\nElgin B-ORG\nCity I-ORG\n0 O\nWhitehill B-ORG\n3 O\n\nPostponed O\n: O\nAlbion B-ORG\nv O\nForfar B-ORG\n, O\nHuntly B-ORG\nv O\nClyde B-ORG\n( O\nboth O\nnow O\nplay O\non O\n\nDecember O\n14 O\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nLEAGUE O\nAND O\nCUP O\nRESULTS O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nResults O\nof O\nEnglish B-MISC\nleague O\nand O\ncup O\n\nmatches O\non O\nSaturday O\n: O\n\nPremier B-MISC\nleague I-MISC\n\nArsenal B-ORG\n2 O\nDerby B-ORG\n2 O\n\nChelsea B-ORG\n2 O\nEverton B-ORG\n2 O\n\nCoventry B-ORG\n1 O\nTottenham B-ORG\n2 O\n\nLeicester B-ORG\n1 O\nBlackburn B-ORG\n1 O\n\nLiverpool B-ORG\n0 O\nSheffield B-ORG\nWednesday I-ORG\n1 O\n\nMiddlesbrough B-ORG\n0 O\nLeeds B-ORG\n0 O\n\nSouthampton B-ORG\n0 O\nAston B-ORG\nVilla I-ORG\n1 O\n\nSunderland B-ORG\n1 O\nWimbledon B-ORG\n3 O\n\nDivision O\none O\n\nBarnsley B-ORG\n3 O\nSouthend B-ORG\n0 O\n\nBirmingham B-ORG\n0 O\nGrimsby B-ORG\n0 O\n\nCharlton B-ORG\n2 O\nSwindon B-ORG\n0 O\n\nCrystal B-ORG\nPalace I-ORG\n2 O\nOxford B-ORG\n2 O\n\nHuddersfield B-ORG\n2 O\nNorwich B-ORG\n0 O\n\nIpswich B-ORG\n0 O\nWolverhampton B-ORG\n0 O\n\nManchester B-ORG\nCity I-ORG\n3 O\nBradford B-ORG\n2 O\n\nOldham B-ORG\n0 O\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\n2 O\n\nReading B-ORG\n0 O\nPort B-ORG\nVale I-ORG\n1 O\n\nSheffield B-ORG\nUnited I-ORG\n1 O\nPortsmouth B-ORG\n0 O\n\nStoke B-ORG\n2 O\nTranmere B-ORG\n0 O\n\nPlaying O\nSunday O\n: O\nWest B-ORG\nBromwich I-ORG\nv O\nBolton B-ORG\n\nF.A. B-MISC\nChallenge I-MISC\nCup I-MISC\nsecond O\nround O\n\nBarnet B-ORG\n3 O\nWycombe B-ORG\n3 O\n\nBlackpool B-ORG\n0 O\nHednesford B-ORG\n1 O\n\nBristol B-ORG\nCity I-ORG\n9 O\nSt B-ORG\nAlbans I-ORG\n2 O\n\nCambridge B-ORG\nUnited I-ORG\n0 O\nWoking B-ORG\n2 O\n\nCarlisle B-ORG\n1 O\nDarlington B-ORG\n0 O\n\nChester B-ORG\n1 O\nBoston B-ORG\n0 O\n\nChesterfield B-ORG\n2 O\nScarborough B-ORG\n0 O\n\nEnfield B-ORG\n1 O\nPeterborough B-ORG\n1 O\n\nHull B-ORG\n1 O\nCrewe B-ORG\n5 O\n\nLeyton B-ORG\nOrient I-ORG\n1 O\nStevenage B-ORG\n2 O\n\nLuton B-ORG\n2 O\nBoreham B-ORG\nWood I-ORG\n1 O\n\nMansfield B-ORG\n0 O\nStockport B-ORG\n3 O\n\nNotts B-ORG\nCounty I-ORG\n3 O\nRochdale B-ORG\n1 O\n\nPreston B-ORG\n2 O\nYork B-ORG\n3 O\n\nSudbury B-ORG\nTown I-ORG\n1 O\nBrentford B-ORG\n3 O\n\nWalsall B-ORG\n1 O\nBurnley B-ORG\n1 O\n\nWatford B-ORG\n5 O\nAshford B-ORG\nTown I-ORG\n0 O\n\nWrexham B-ORG\n2 O\nScunthorpe B-ORG\n2 O\n\nCardiff B-ORG\n0 O\nGillingham B-ORG\n2 O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nCAMPESE B-PER\nSIGNS O\nOFF O\nWITH O\nTRY O\nIN O\nWALLABY B-LOC\nROMP O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nAustralia B-LOC\nbade O\nfarewell O\nto O\nDavid B-PER\nCampese I-PER\nin O\nspectacular O\nfashion O\nby O\noverwhelming O\nthe O\nBarbarians B-ORG\n39-12 O\nin O\nthe O\nfinal O\nmatch O\nof O\ntheir O\nEuropean B-MISC\ntour O\nat O\nTwickenham B-LOC\non O\nSaturday O\n. O\n\nThe O\nWallabies B-ORG\nran O\nin O\nfive O\ntries O\nwith O\nCampese B-PER\n, O\nwho O\nhas O\nretired O\nfrom O\ntest O\nrugby O\nafter O\ncollecting O\n101 O\ncaps O\nand O\na O\nworld O\nrecord O\n64 O\ntries O\n, O\nadding O\none O\nlast O\ntouchdown O\nin O\na O\nWallaby B-ORG\njersey O\nbefore O\ndeparting O\nthe O\ninternational O\ngame O\n. O\n\nThe O\nBarbarians B-ORG\nincluded O\n14 O\ninternationals O\nbut O\n, O\nwith O\nonly O\ntwo O\npre-match O\npractice O\nsessions O\nbehind O\nthem O\n, O\nproved O\nno O\nreal O\nmatch O\nfor O\na O\nWallaby B-ORG\nside O\ndetermined O\nto O\nfinish O\ntheir O\n12-match O\ntour O\nunbeaten O\n. O\n\nThe O\ntouring O\nteam O\nwere O\n27-0 O\nahead O\nby O\nhalf-time O\nbefore O\neasing O\nup O\nin O\nthe O\nsecond-half O\n. O\n\nFull-back O\nMatthew B-PER\nBurke I-PER\nfinished O\nwith O\na O\npersonal O\nhaul O\nof O\n24 O\npoints O\nto O\ntake O\nhis O\ntour O\naggregate O\nto O\n136 O\n. O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nAUSTRALIA B-LOC\nBEAT O\nBARBARIANS B-ORG\n39-12 O\n. O\n\nLONDON B-LOC\n1996-12-07 O\n\nAustralia B-LOC\nbeat O\nthe O\nBarbarians B-ORG\n39-12 O\n( O\nhalftime O\n27-0 O\n) O\nin O\nthe O\nfinal O\nmatch O\nof O\ntheir O\nEuropean B-MISC\ntour O\non O\nSaturday O\n: O\n\nScorers O\n: O\n\nAustralia B-LOC\n- O\nTries O\n: O\nMatthew B-PER\nBurke I-PER\n( O\n2 O\n) O\n, O\nJoe B-PER\nRoff I-PER\n, O\nDavid B-PER\nCampese I-PER\n, O\nTim B-PER\nHoran I-PER\n. O\n\nPenalties O\n: O\nBurke B-PER\n( O\n2 O\n) O\n. O\n\nConversions O\n: O\nBurke B-PER\n( O\n4 O\n) O\n. O\n\nBarbarians B-ORG\n- O\nTries O\n: O\nAlan B-PER\nBateman I-PER\n, O\nScott B-PER\nQuinnell I-PER\n. O\n\nConversion O\n: O\nRob B-PER\nAndrew I-PER\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nZIMBABWE B-MISC\nOPEN I-MISC\nTHIRD O\nROUND O\nSCORES O\n. O\n\nHARARE B-LOC\n1996-12-07 O\n\nLeading O\nthird O\nround O\nscores O\nin O\nthe O\n\nZimbabwe B-MISC\nOpen I-MISC\non O\nSaturday O\n( O\nSouth B-MISC\nAfrican I-MISC\nunless O\nstated O\n) O\n: O\n\n201 O\nMark B-PER\nMcNulty I-PER\n( O\nZimbabwe B-LOC\n) O\n72 O\n61 O\n68 O\n\n205 O\nDes B-PER\nTerblanche I-PER\n65 O\n67 O\n73 O\n\n206 O\nNick B-PER\nPrice I-PER\n( O\nZimbabwe B-LOC\n) O\n68 O\n68 O\n70 O\n\n207 O\nClinton B-PER\nWhitelaw I-PER\n70 O\n70 O\n67 O\n, O\nMark B-PER\nCayeux I-PER\n( O\nZimbabwe B-LOC\n) O\n\n69 O\n69 O\n69 O\n, O\nJustin B-PER\nHobday I-PER\n71 O\n65 O\n71 O\n\n209 O\nSteve B-PER\nvan I-PER\nVuuren I-PER\n65 O\n69 O\n75 O\n\n210 O\nBrett B-PER\nLiddle I-PER\n75 O\n65 O\n70 O\n\n211 O\nHugh B-PER\nBaiocchi I-PER\n73 O\n67 O\n71 O\n, O\nGreg B-PER\nReid I-PER\n72 O\n68 O\n71 O\n, O\nMark B-PER\n\nMurless B-PER\n71 O\n67 O\n73 O\n\n212 O\nTrevor B-PER\nDodds I-PER\n( O\nNamibia B-LOC\n) O\n72 O\n69 O\n71 O\n, O\nSchalk B-PER\nvan I-PER\nder I-PER\n\nMerwe B-PER\n( O\nNamibia B-LOC\n) O\n67 O\n73 O\n72 O\n, O\nHennie B-PER\nSwart I-PER\n75 O\n64 O\n73 O\n, O\n\nAndrew B-PER\nPitts I-PER\n( O\nU.S. B-LOC\n) O\n69 O\n67 O\n76 O\n\n213 O\nSean B-PER\nFarrell I-PER\n( O\nZimbabwe B-LOC\n) O\n77 O\n68 O\n68 O\n, O\nGlen B-PER\nCayeux I-PER\n\n( O\nZimbabwe B-LOC\n) O\n75 O\n68 O\n70 O\n, O\nNic B-PER\nHenning I-PER\n73 O\n70 O\n70 O\n, O\nDion B-PER\n\nFourie B-PER\n69 O\n73 O\n71 O\n\n214 O\nSteven B-PER\nWaltman I-PER\n72 O\n70 O\n72 O\n, O\nBradford B-PER\nVaughan I-PER\n72 O\n71 O\n\n71 O\n, O\nAndrew B-PER\nPark I-PER\n72 O\n67 O\n75 O\n, O\nDesvonde B-PER\nBotes I-PER\n72 O\n68 O\n74 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nREINSTATED O\nALBANIA B-LOC\nNAMES O\nSQUAD O\nTO O\nPLAY O\nN.IRELAND B-LOC\n. O\n\nTIRANA B-LOC\n1996-12-07 O\n\nAlbanian B-MISC\ncoach O\nAstrit B-PER\nHafizi I-PER\nsaid O\non O\nSaturday O\nit O\nwas O\nimportant O\nthat O\nhis O\nplayers O\nbrush O\naside O\nthe O\ncountry O\n's O\nshort O\nban O\nby O\nFIFA B-ORG\nin O\norder O\nto O\nconcentrate O\non O\nnext O\nSaturday'sWorld B-MISC\nCup I-MISC\ngroup O\nnine O\nqualifier O\nagainst O\nNorthern B-LOC\nIreland I-LOC\n. O\n\nWorld O\nsoccer O\n's O\ngoverning O\nbody O\nreinstated O\nAlbania B-LOC\nlast O\nTuesday O\nafter O\nthe O\nBalkan B-LOC\ncountry O\n's O\ngovernment O\nlifted O\nsuspensions O\non O\nvarious O\nsoccer O\nofficials O\n. O\n\nFIFA B-ORG\nhad O\nbanned O\nAlbania B-LOC\nindefinitely O\nafter O\nits O\nsports O\nministry O\nhad O\nordered O\nthe O\nsuspension O\nof O\nAlbanian B-ORG\nFootball I-ORG\nAssociation I-ORG\ngeneral O\nsecretary O\nEduard B-PER\nDervishi I-PER\nand O\ndissolved O\nthe O\nexecutive O\ncommittee O\n. O\n\n\" O\nWe O\nwould O\nbe O\nvery O\nhappy O\nwith O\na O\ndraw O\nin O\nBelfast B-LOC\n, O\n\" O\nsaid O\nHafizi B-PER\n. O\n\" O\n\nEspecially O\nif O\none O\ntakes O\ninto O\nconsideration O\nour O\ndifficult O\npost-suspension O\nsituation O\nand O\nthe O\nfact O\nNorthern B-LOC\nIreland I-LOC\nis O\nvery O\nkeen O\nto O\nwin O\n. O\n\" O\n\nRegular O\ndefender O\nArtur B-PER\nLekbello I-PER\n, O\nwho O\nis O\ninjured O\n, O\nwas O\nmissing O\nfrom O\nHafizi B-PER\n's O\nsquad O\nnamed O\non O\nSaturday O\nfor O\nthe O\nBelfast B-LOC\nmatch O\n. O\n\nSquad O\n: O\n\nGoalkeepers O\n- O\nBlendi B-PER\nNallbani I-PER\n, O\nArmir B-PER\nGrima I-PER\n\nDefenders O\n- O\nRudi B-PER\nVata I-PER\n, O\nSaimir B-PER\nMalko I-PER\n, O\nArjan B-PER\nXhumba I-PER\n, O\nIlir B-PER\nShulku I-PER\n, O\nAfrim B-PER\nTole I-PER\n, O\nNevil B-PER\nDede I-PER\n, O\nArjan B-PER\nBellai I-PER\n\nMidfielders O\n- O\nBledar B-PER\nKola I-PER\n, O\nAltin B-PER\nHaxhi I-PER\n, O\nSokol B-PER\nPrenga I-PER\n, O\nErvin B-PER\nFakaj I-PER\n\nForwards O\n- O\nAltin B-PER\nRraklli I-PER\n, O\nViktor B-PER\nPaco I-PER\n, O\nFatmir B-PER\nVata I-PER\n, O\nErjon B-PER\nBogdani I-PER\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nJONES B-PER\nHITS O\nCENTURY O\nAS O\nVICTORIA B-ORG\nFIGHT O\nBACK O\n. O\n\nHOBART B-LOC\n, O\nAustralia B-LOC\n1996-12-07 O\n\nFormer O\nAustralia B-LOC\ntest O\nbatsman O\nDean B-PER\nJones I-PER\nhit O\nan O\nunbeaten O\n130 O\nto O\nlead O\nVictoria B-LOC\n's O\nfightback O\nin O\ntheir O\nSheffield B-MISC\nShield I-MISC\nmatch O\nagainst O\nTasmania B-ORG\non O\nSaturday O\n. O\n\nReplying O\nto O\nthe O\nhome O\nside O\n's O\nfirst O\ninnings O\n481 O\nfor O\neight O\ndeclared O\n, O\nVictoria B-LOC\nreached O\n220 O\nfor O\nthree O\nat O\nclose O\nof O\nplay O\non O\nthe O\nsecond O\nday O\nof O\nthe O\nfour-day O\nmatch O\nat O\nHobart B-LOC\n's O\nBellerive B-LOC\nOval I-LOC\n. O\n\nJones B-PER\nbecame O\nthe O\nfourth O\ncentury-maker O\nof O\nthe O\nmatch O\n, O\nequalling O\nthe O\nfeats O\nof O\nTasmanian B-MISC\ntrio O\nDavid B-PER\nBoon I-PER\n, O\nShaun B-PER\nYoung I-PER\nand O\nMichael B-PER\nDiVenuto I-PER\n. O\n\nJones B-PER\n, O\nwho O\ntook O\nover O\nas O\ncaptain O\nfor O\nthe O\nmatch O\nin O\nthe O\nabsence O\nof O\nAustralia B-LOC\ntest O\nleg-spinner O\nShane B-PER\nWarne I-PER\n, O\nadded O\n195 O\nruns O\nfor O\nthe O\nthird O\nwicket O\nwith O\nleft-hander O\nLaurie B-PER\nHarper I-PER\n. O\n\nHarper B-PER\nwas O\neventually O\ndismissed O\nfor O\n77 O\nafter O\nthe O\npair O\njoined O\nforces O\nwith O\ntheir O\nside O\nreeling O\non O\nnine O\nfor O\ntwo O\n. O\n\nEarlier O\n, O\nformer O\nAustralia B-LOC\ntest O\nbatsman O\nDavid B-PER\nBoon I-PER\nscored O\n118 O\nand O\nall-rounder O\nShaun B-PER\nYoung I-PER\nhit O\n113 O\n. O\n\nThe O\npair O\nhammered O\n36 O\nboundaries O\nbetween O\nthem O\n. O\n\nPace B-PER\nbowler O\nIan B-PER\nHarvey I-PER\nclaimed O\nthree O\nfor O\n81 O\nfor O\nVictoria B-LOC\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nSHEFFIELD B-MISC\nSHIELD I-MISC\nSCORE O\n. O\n\nHOBART B-LOC\n, O\nAustralia B-LOC\n1996-12-07 O\n\nClose O\nof O\nplay O\nscore O\non O\nthe O\nsecond O\nday O\nof O\nthe O\nfour-day O\nSheffield B-MISC\nShield I-MISC\ncricket O\nmatch O\nbetween O\nTasmania B-ORG\nand O\nVictoria B-ORG\nat O\nBellerive B-LOC\nOval I-LOC\non O\nSaturday O\n: O\n\nTasmania B-ORG\n481 O\nfor O\neight O\ndeclared O\n( O\nMichael B-PER\nDiVenuto I-PER\n119 O\n, O\nDavid B-PER\nBoon I-PER\n118 O\n, O\nShaun B-PER\nYoung I-PER\n113 O\n) O\n; O\nVictoria B-ORG\n220 O\nfor O\nthree O\n( O\nDean B-PER\nJones I-PER\n130 O\nnot O\nout O\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSOUTH B-LOC\nKOREA I-LOC\nMOVE O\nCLOSE O\nTO O\nQUARTER-FINAL O\nBERTH O\n. O\n\nABU B-LOC\nDHABI I-LOC\n1996-12-07 O\n\nSouth B-LOC\nKorea I-LOC\nmade O\nvirtually O\ncertain O\nof O\nan O\nAsian B-MISC\nCup I-MISC\nquarter-final O\nspot O\nwith O\na O\n4-2 O\nwin O\nover O\nIndonesia B-LOC\nin O\na O\nGroup O\nA O\nmatch O\non O\nSaturday O\n. O\n\nAfter O\ngoing O\nfour O\nup O\nin O\nthe O\nfirst O\n55 O\nminutes O\nSouth B-LOC\nKorea I-LOC\nallowed O\nIndonesia B-LOC\n, O\nnewcomers O\nto O\nAsian B-MISC\nCup I-MISC\nfinals O\n, O\nback O\ninto O\nthe O\nmatch O\n, O\nconceding O\ntwo O\ngoals O\nfrom O\nrare O\ncounter O\nattacks O\n. O\n\nKim B-PER\nDo I-PER\nHoon I-PER\nopened O\nthe O\nscoring O\nfor O\nSouth B-LOC\nKorea I-LOC\nin O\nonly O\nthe O\nfifth O\nminute O\n, O\nturning O\nunmarked O\non O\nthe O\npenalty O\nspot O\nto O\nfire O\na O\nshot O\ninto O\nthe O\ntop O\ncorner O\n. O\n\nIt O\nlooked O\nlike O\nturning O\ninto O\na O\nrout O\nas O\nHwang B-PER\nSun I-PER\nHong I-PER\nrapidly O\nadded O\ntwo O\nmore O\nin O\nthe O\nseventh O\nand O\n15th O\nminutes O\nbut O\nalthough O\nthe O\nKoreans B-MISC\ncontinued O\nto O\ndominate O\nthey O\nfailed O\nto O\nadd O\nto O\nthe O\nscore O\nbefore O\nthe O\ninterval O\n. O\n\nBut O\nthey O\nstarted O\nthe O\nsecond O\nhalf O\nwhere O\nthey O\nhad O\nleft O\noff O\nand O\nit O\nwas O\nnot O\nlong O\nbefore O\nthey O\nwent O\nfour O\nup O\n, O\nKo B-PER\nJeong I-PER\nWoon I-PER\nheading O\nin O\nfrom O\na O\nfree O\nkick O\nin O\nthe O\n55th O\nminute O\n. O\n\nThe O\nKoreans B-MISC\nthen O\nappeared O\nto O\nrelax O\n, O\nallowing O\nthe O\nIndonesians B-MISC\nto O\nget O\nback O\ninto O\nthe O\nmatch O\n. O\n\nRonny B-PER\nWabia I-PER\nscored O\nfor O\nIndonesia B-LOC\nthree O\nminutes O\nlater O\ndirect O\nfrom O\na O\na O\ncorner O\nkick O\nthat O\nKorean B-MISC\ngoalkeeper O\nKim B-PER\nByung I-PER\nreached O\nwith O\none O\nhand O\nbut O\nfailed O\nto O\nkeep O\nout O\n. O\n\nWith O\n65 O\nminutes O\ngone O\nIndonesia B-LOC\n's O\nWidodo B-PER\nPutra I-PER\n, O\nwho O\nscored O\na O\nspectacular O\ngoal O\nagainst O\nKuwait B-LOC\non O\nWednesday O\n, O\nwas O\nagain O\non O\ntarget O\n, O\nbreaking O\nthrough O\nthe O\nKorean B-MISC\ndefence O\nto O\nbeat O\nthe O\nkeeper O\nwith O\na O\nlow O\nshot O\n. O\n\nIndonesian B-MISC\nkeeper O\nHendro B-PER\nKartiko I-PER\nproduced O\na O\nstring O\nof O\nfine O\nsaves O\nto O\nprevent O\nthe O\nKoreans B-MISC\nincreasing O\ntheir O\nlead O\n. O\n\nTeams O\n: O\n\nIndonesia B-LOC\n: O\n20 O\n- O\nHendro B-PER\nKartiko I-PER\n; O\n2 O\n- O\nAgung B-PER\nSetyabudi I-PER\n; O\n3 O\n- O\nSuwandi B-PER\nSiswoyo I-PER\n; O\n4 O\n- O\nYeyen B-PER\nTumera I-PER\n; O\n5 O\n- O\nAples B-PER\nTecuari I-PER\n; O\n6 O\n- O\nSudiriman B-PER\n; O\n7 O\n- O\nWidodo B-PER\nGahyo I-PER\nPurta I-PER\n; O\n8 O\n- O\nRonny B-PER\nWabia I-PER\n; O\n11 O\n- O\nBima B-PER\nSakti I-PER\n; O\n12 O\n- O\nChris B-PER\nYarangga I-PER\n( O\n15 O\n- O\nFrancis B-PER\nWewengken I-PER\n36 O\n) O\n; O\n16 O\n- O\nMarzuki B-PER\nBadriawan I-PER\n. O\n\nSouth B-LOC\nKorea I-LOC\n: O\n1 O\n- O\nKim B-PER\nByung I-PER\nJi I-PER\n; O\n2 O\n- O\nKim B-PER\nPan I-PER\nKeun I-PER\n; O\n5 O\n- O\nHuh B-PER\nKi I-PER\nTae I-PER\n; O\n8 O\n- O\nRoh B-PER\nSang I-PER\nRae I-PER\n( O\n7 O\n- O\nSin B-PER\nTae I-PER\nYong I-PER\n33 O\n) O\n; O\n9 O\n- O\nKim B-PER\nDo I-PER\nHoon I-PER\n; O\n11 O\n- O\nKo B-PER\nJeong I-PER\nWoon I-PER\n; O\n17 O\n- O\nHa B-PER\nSeok I-PER\nJu I-PER\n; O\n18 O\n- O\nHwang B-PER\nSun I-PER\nHong I-PER\n; O\n22 O\n- O\nLee B-PER\nYoung I-PER\nJin I-PER\n; O\n23 O\n- O\nYoo B-PER\nSang I-PER\nChul I-PER\n; O\n24 O\n- O\nKim B-PER\nJoo I-PER\nSung I-PER\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nISRAELI B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nJERUSALEM B-LOC\n1996-12-07 O\n\nResults O\nof O\nfirst O\ndivision O\nsoccer O\n\nmatches O\nplayed O\nover O\nthe O\nweekend O\n: O\n\nZafririm B-ORG\nHolon I-ORG\n1 O\nHapoel B-ORG\nPetah I-ORG\nTikva I-ORG\n1 O\n\nMaccabi B-ORG\nHaifa I-ORG\n1 O\nHapoel B-ORG\nTaibe I-ORG\n1 O\n\nHapoel B-ORG\nKfar I-ORG\nSava I-ORG\n1 O\nBnei B-ORG\nYehuda I-ORG\n0 O\n\nHapoel B-ORG\nTel I-ORG\nAviv I-ORG\n1 O\nBetar B-ORG\nJerusalem I-ORG\n4 O\n\nHapoel B-ORG\nJerusalem I-ORG\n0 O\nMaccabi B-ORG\nTel I-ORG\nAviv I-ORG\n4 O\n\nIroni B-ORG\nRishon I-ORG\nLezion I-ORG\n1 O\nMaccabi B-ORG\nHerzliya I-ORG\n0 O\n\nHapoel B-ORG\nBeit I-ORG\nShe'an I-ORG\n2 O\nHapoel B-ORG\nBeersheba I-ORG\n1 O\n\nMaccabi B-ORG\nPetah I-ORG\nTikva I-ORG\n0 O\nHapoel B-ORG\nHaifa I-ORG\n2 O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nBetar B-ORG\nJerusalem I-ORG\n12 O\n10 O\n2 O\n0 O\n28 O\n7 O\n32 O\n\nHapoel B-ORG\nPetah I-ORG\nTikva I-ORG\n12 O\n9 O\n2 O\n1 O\n27 O\n13 O\n29 O\n\nHapoel B-ORG\nBeersheba I-ORG\n12 O\n8 O\n0 O\n4 O\n18 O\n9 O\n24 O\n\nMaccabi B-ORG\nTel I-ORG\nAviv I-ORG\n12 O\n6 O\n4 O\n2 O\n21 O\n14 O\n22 O\n\nMaccabi B-ORG\nPetah I-ORG\nTikva I-ORG\n12 O\n6 O\n2 O\n4 O\n14 O\n12 O\n20 O\n\nBnei B-ORG\nYehuda I-ORG\n12 O\n6 O\n2 O\n4 O\n15 O\n15 O\n20 O\n\nHapoel B-ORG\nHaifa I-ORG\n12 O\n6 O\n1 O\n5 O\n21 O\n16 O\n19 O\n\nMaccabi B-ORG\nHaifa I-ORG\n12 O\n4 O\n4 O\n4 O\n14 O\n15 O\n16 O\n\nHapoel B-ORG\nKfar I-ORG\nSava I-ORG\n12 O\n5 O\n1 O\n6 O\n10 O\n11 O\n16 O\n\nHapoel B-ORG\nJerusalem I-ORG\n12 O\n4 O\n1 O\n7 O\n10 O\n18 O\n13 O\n\nIroni B-ORG\nRishon I-ORG\nLezion O\n12 O\n4 O\n1 O\n7 O\n13 O\n24 O\n13 O\n\nZafririm B-ORG\nHolon I-ORG\n12 O\n2 O\n4 O\n6 O\n8 O\n14 O\n10 O\n\nMaccabi B-ORG\nHerzliya I-ORG\n12 O\n3 O\n1 O\n8 O\n5 O\n12 O\n10 O\n\nHapoel B-ORG\nTaiba I-ORG\n12 O\n3 O\n1 O\n8 O\n10 O\n21 O\n10 O\n\nHapoel B-ORG\nBeit I-ORG\nShe'an I-ORG\n12 O\n2 O\n3 O\n7 O\n9 O\n13 O\n9 O\n\nHapoel B-ORG\nTel I-ORG\nAviv I-ORG\n12 O\n2 O\n3 O\n7 O\n7 O\n16 O\n9 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nASIAN B-MISC\nCUP I-MISC\nRESULTS O\n. O\n\nABU B-LOC\nDHABI I-LOC\n1996-12-07 O\n\nResults O\nof O\nAsian B-MISC\nCup I-MISC\ngroup O\nA O\nmatches O\non O\nSaturday O\n: O\n\nUnited B-LOC\nArab I-LOC\nEmirates I-LOC\n3 O\nKuwait B-LOC\n2 O\n( O\nhalftime O\n0-2 O\n) O\n\nScorers O\n: O\n\nUAE B-LOC\n- O\nHassan B-PER\nAhmed I-PER\n53 O\n, O\nAdnan B-PER\nAl I-PER\nTalyani I-PER\n55 O\n, O\nBakhit B-PER\nSaad I-PER\n80 O\n\nKuwait B-LOC\n- O\nJassem B-PER\nAl-Huwaidi I-PER\n9 O\n, O\n44 O\n\nAttendance O\n: O\n15,000 O\n\nSouth B-LOC\nKorea I-LOC\n4 O\nIndonesia B-LOC\n2 O\n( O\n3-0 O\n) O\n\nScorers O\n: O\n\nSouth B-LOC\nKorea I-LOC\n- O\nKim B-PER\nDo I-PER\nHoon I-PER\n5 O\n, O\nHwang B-PER\nSun I-PER\nHong I-PER\n7 O\nand O\n15 O\n, O\nKoo B-PER\n\nJeon B-PER\nWoon I-PER\n55 O\n\nIndonesia B-LOC\n- O\nRonny B-PER\nWabia I-PER\n58 O\n, O\nWidodo B-PER\nPutra I-PER\n65 O\n\nAttendance O\n: O\n2,000 O\n\nGroup O\nA O\nstandings O\n( O\ntabulate O\nunder O\n: O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\n\ngoals O\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nSouth B-LOC\nKorea I-LOC\n2 O\n1 O\n1 O\n0 O\n5 O\n3 O\n4 O\n\nUAE B-LOC\n2 O\n1 O\n1 O\n0 O\n4 O\n3 O\n4 O\n\nKuwait B-LOC\n2 O\n0 O\n1 O\n1 O\n4 O\n5 O\n1 O\n\nIndonesia B-LOC\n2 O\n0 O\n1 O\n1 O\n4 O\n6 O\n1 O\n\n-DOCSTART- O\n\nNBA B-ORG\nBASKETBALL O\n- O\nSTANDINGS O\nAFTER O\nFRIDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-07 O\n\nStandings O\nof O\nNational B-ORG\n\nBasketball B-ORG\nAssociation I-ORG\nteams O\nafter O\ngames O\nplayed O\non O\nFriday O\n\n( O\ntabulate O\nunder O\nwon O\n, O\nlost O\n, O\npercentage O\n, O\ngames O\nbehind O\n) O\n: O\n\nEASTERN O\nCONFERENCE O\n\nATLANTIC B-LOC\nDIVISION O\n\nW O\nL O\nPCT O\nGB O\n\nMIAMI B-ORG\n14 O\n5 O\n.737 O\n- O\n\nNEW B-ORG\nYORK I-ORG\n11 O\n6 O\n.647 O\n2 O\n\nORLANDO B-ORG\n8 O\n7 O\n.533 O\n4 O\n\nWASHINGTON B-ORG\n7 O\n9 O\n.438 O\n5 O\n1/2 O\n\nPHILADELPHIA B-ORG\n7 O\n10 O\n.412 O\n6 O\n\nNEW B-ORG\nJERSEY I-ORG\n4 O\n10 O\n.286 O\n7 O\n1/2 O\n\nBOSTON B-ORG\n4 O\n13 O\n.235 O\n9 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nCHICAGO B-ORG\n17 O\n1 O\n.944 O\n- O\n\nDETROIT B-ORG\n14 O\n3 O\n.824 O\n2 O\n1/2 O\n\nCLEVELAND B-ORG\n11 O\n6 O\n.647 O\n5 O\n1/2 O\n\nATLANTA B-ORG\n10 O\n8 O\n.556 O\n7 O\n\nMILWAUKEE B-ORG\n8 O\n8 O\n.500 O\n8 O\n\nINDIANA B-ORG\n8 O\n8 O\n.500 O\n8 O\n\nCHARLOTTE B-ORG\n8 O\n9 O\n.471 O\n8 O\n1/2 O\n\nTORONTO B-ORG\n6 O\n11 O\n.353 O\n10 O\n1/2 O\n\nWESTERN O\nCONFERENCE O\n\nMIDWEST O\nDIVISION O\n\nW O\nL O\nPCT O\nGB O\n\nHOUSTON B-ORG\n16 O\n2 O\n.889 O\n- O\n\nUTAH B-ORG\n15 O\n2 O\n.882 O\n1/2 O\n\nMINNESOTA B-ORG\n7 O\n11 O\n.389 O\n9 O\n\nDALLAS B-ORG\n6 O\n11 O\n.353 O\n9 O\n1/2 O\n\nDENVER B-ORG\n5 O\n14 O\n.263 O\n11 O\n1/2 O\n\nSAN B-ORG\nANTONIO I-ORG\n3 O\n14 O\n.176 O\n12 O\n1/2 O\n\nVANCOUVER B-ORG\n3 O\n16 O\n.158 O\n13 O\n1/2 O\n\nPACIFIC B-LOC\nDIVISION O\n\nW O\nL O\nPCT O\nGB O\n\nSEATTLE B-ORG\n15 O\n5 O\n.750 O\n- O\n\nLA B-ORG\nLAKERS I-ORG\n14 O\n7 O\n.667 O\n1 O\n1/2 O\n\nPORTLAND B-ORG\n12 O\n8 O\n.600 O\n3 O\n\nLA B-ORG\nCLIPPERS I-ORG\n7 O\n11 O\n.389 O\n7 O\n\nGOLDEN B-ORG\nSTATE I-ORG\n6 O\n13 O\n.316 O\n8 O\n1/2 O\n\nSACRAMENTO B-ORG\n6 O\n13 O\n.316 O\n8 O\n1/2 O\n\nPHOENIX B-ORG\n3 O\n14 O\n.176 O\n10 O\n1/2 O\n\nSATURDAY O\n, O\nDECEMBER O\n7 O\nSCHEDULE O\n\nTORONTO B-ORG\nAT O\nATLANTA B-LOC\n\nLA B-ORG\nCLIPPERS I-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nMILWAUKEE B-ORG\nAT O\nWASHINGTON B-LOC\n\nDETROIT B-ORG\nAT O\nNEW B-LOC\nJERSEY I-LOC\n\nMIAMI B-ORG\nAT O\nCHICAGO B-LOC\n\nVANCOUVER B-ORG\nAT O\nDALLAS B-LOC\n\nPHILADELPHIA B-ORG\nAT O\nHOUSTON B-LOC\n\nUTAH B-ORG\nAT O\nDENVER B-LOC\n\nCHARLOTTE B-ORG\nAT O\nSEATTLE B-LOC\n\n-DOCSTART- O\n\nNBA B-ORG\nBASKETBALL O\n- O\nFRIDAY O\n'S O\nRESULTS O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-07 O\n\nResults O\nof O\nNational B-ORG\nBasketball I-ORG\n\nAssociation B-ORG\ngames O\non O\nFriday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nNew B-ORG\nJersey I-ORG\n110 O\nBOSTON B-ORG\n108 O\n( O\nOT O\n) O\n\nDETROIT B-ORG\n93 O\nCleveland B-ORG\n81 O\n\nNew B-ORG\nYork I-ORG\n103 O\nMIAMI B-ORG\n85 O\n\nPhoenix B-ORG\n101 O\nSACRAMENTO B-ORG\n95 O\n\nVancouver B-ORG\n105 O\nSAN B-ORG\nANTONIO I-ORG\n89 O\n\nUTAH B-ORG\n106 O\nMinnesota B-ORG\n95 O\n\nPORTLAND B-ORG\n97 O\nCharlotte B-ORG\n93 O\n\nIndiana B-ORG\n86 O\nGOLDEN B-ORG\nSTATE I-ORG\n71 O\n\nLA B-ORG\nLAKERS I-ORG\n92 O\nOrlando B-ORG\n81 O\n\n-DOCSTART- O\n\nNHL B-ORG\nICE O\nHOCKEY O\n- O\nSTANDINGS O\nAFTER O\nFRIDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-07 O\n\nStandings O\nof O\nNational B-ORG\nHockey I-ORG\n\nLeague B-ORG\nteams O\nafter O\ngames O\nplayed O\non O\nFriday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\ntied O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nEASTERN O\nCONFERENCE O\n\nNORTHEAST O\nDIVISION O\n\nW O\nL O\nT O\nGF O\nGA O\nPTS O\n\nHARTFORD B-ORG\n12 O\n7 O\n6 O\n77 O\n76 O\n30 O\n\nBUFFALO B-ORG\n13 O\n12 O\n2 O\n78 O\n77 O\n28 O\n\nMONTREAL B-ORG\n11 O\n14 O\n4 O\n99 O\n104 O\n26 O\n\nBOSTON B-ORG\n10 O\n11 O\n4 O\n74 O\n84 O\n24 O\n\nPITTSBURGH B-ORG\n10 O\n13 O\n3 O\n86 O\n94 O\n23 O\n\nOTTAWA B-ORG\n7 O\n12 O\n6 O\n64 O\n77 O\n20 O\n\nATLANTIC B-LOC\nDIVISION O\n\nW O\nL O\nT O\nGF O\nGA O\nPTS O\n\nFLORIDA B-ORG\n17 O\n4 O\n6 O\n83 O\n53 O\n40 O\n\nPHILADELPHIA B-ORG\n15 O\n12 O\n2 O\n81 O\n78 O\n32 O\n\nNEW B-ORG\nJERSEY I-ORG\n14 O\n10 O\n1 O\n61 O\n61 O\n29 O\n\nWASHINGTON B-ORG\n13 O\n13 O\n1 O\n72 O\n71 O\n27 O\n\nNY B-ORG\nRANGERS I-ORG\n11 O\n13 O\n5 O\n97 O\n86 O\n27 O\n\nNY B-ORG\nISLANDERS I-ORG\n7 O\n11 O\n8 O\n65 O\n72 O\n22 O\n\nTAMPA B-ORG\nBAY I-ORG\n8 O\n15 O\n2 O\n69 O\n81 O\n18 O\n\nWESTERN O\nCONFERENCE O\n\nCENTRAL O\nDIVISION O\n\nW O\nL O\nT O\nGF O\nGA O\nPTS O\n\nDETROIT B-ORG\n15 O\n9 O\n4 O\n81 O\n53 O\n34 O\n\nDALLAS B-ORG\n16 O\n10 O\n1 O\n77 O\n66 O\n33 O\n\nST B-ORG\nLOUIS I-ORG\n14 O\n14 O\n0 O\n82 O\n84 O\n28 O\n\nCHICAGO B-ORG\n12 O\n13 O\n3 O\n72 O\n70 O\n27 O\n\nTORONTO B-ORG\n11 O\n16 O\n0 O\n81 O\n95 O\n22 O\n\nPHOENIX B-ORG\n9 O\n13 O\n4 O\n61 O\n74 O\n22 O\n\nPACIFIC B-LOC\nDIVISION O\n\nW O\nL O\nT O\nGF O\nGA O\nPTS O\n\nCOLORADO B-ORG\n17 O\n7 O\n4 O\n100 O\n60 O\n38 O\n\nVANCOUVER B-ORG\n14 O\n11 O\n1 O\n84 O\n83 O\n29 O\n\nEDMONTON B-ORG\n14 O\n14 O\n1 O\n99 O\n90 O\n29 O\n\nLOS B-ORG\nANGELES I-ORG\n11 O\n13 O\n3 O\n72 O\n83 O\n25 O\n\nSAN B-ORG\nJOSE I-ORG\n10 O\n13 O\n4 O\n69 O\n87 O\n24 O\n\nANAHEIM B-ORG\n9 O\n14 O\n5 O\n74 O\n87 O\n23 O\n\nCALGARY B-ORG\n10 O\n16 O\n2 O\n65 O\n77 O\n22 O\n\nSATURDAY O\n, O\nDECEMBER O\n7 O\nSCHEDULE O\n\nPHOENIX B-ORG\nAT O\nNEW B-LOC\nJERSEY I-LOC\n\nCALGARY B-ORG\nAT O\nBOSTON B-LOC\n\nBUFFALO B-ORG\nAT O\nHARTFORD B-LOC\n\nWASHINGTON B-ORG\nAT O\nNY B-LOC\nISLANDERS I-LOC\n\nCHICAGO B-ORG\nAT O\nMONTREAL B-LOC\n\nNY B-ORG\nRANGERS I-ORG\nAT O\nTORONTO B-LOC\n\nANAHEIM B-ORG\nAT O\nPITTSBURGH B-LOC\n\nCOLORADO B-ORG\nAT O\nLOS B-LOC\nANGELES I-LOC\n\nTAMPA B-ORG\nBAY I-ORG\nAT O\nSAN B-LOC\nJOSE I-LOC\n\nOTTAWA B-ORG\nAT O\nVANCOUVER B-LOC\n\n-DOCSTART- O\n\nNHL B-ORG\nICE O\nHOCKEY O\n- O\nFRIDAY O\n'S O\nRESULTS O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-07 O\n\nResults O\nof O\nNational B-ORG\nHockey I-ORG\n\nLeague B-ORG\ngames O\non O\nFriday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nNY B-ORG\nRANGERS I-ORG\n6 O\nToronto B-ORG\n5 O\n\nBUFFALO B-ORG\n1 O\nAnaheim B-ORG\n1 O\n( O\nOT O\n) O\n\nPittsburgh B-ORG\n5 O\nWASHINGTON B-ORG\n3 O\n\nMontreal B-ORG\n3 O\nCHICAGO B-ORG\n1 O\n\nPhiladelphia B-LOC\n6 O\nDALLAS B-LOC\n3 O\n\nSt B-LOC\nLouis I-LOC\n4 O\nCOLORADO B-LOC\n3 O\n\nEDMONTON B-LOC\n5 O\nOttawa B-LOC\n2 O\n\n-DOCSTART- O\n\nNHL B-ORG\nICE O\nHOCKEY O\n- O\nCANUCKS B-ORG\nRW O\nBURE B-PER\nSUSPENDED O\nFOR O\nONE O\nGAME O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-12-06 O\n\nVancouver B-ORG\nCanucks I-ORG\nstar O\nright O\nwing O\nPavel B-PER\nBure I-PER\nwas O\nsuspended O\nfor O\none O\ngame O\nby O\nthe O\nNational B-ORG\nHockey I-ORG\nLeague I-ORG\nand O\nfined O\n$ O\n1,000 O\nFriday O\nfor O\nhis O\nhit O\non O\nBuffalo B-ORG\nSabres I-ORG\ndefenceman O\nGarry B-PER\nGalley I-PER\non O\nWednesday O\n. O\n\nBure B-PER\nreceived O\na O\ndouble-minor O\npenalty O\nfor O\nhigh-sticking O\nwith O\n2:22 O\nleft O\nin O\nthe O\nfirst O\nperiod O\nof O\nWednesday O\n's O\n7-6 O\novertime O\nwin O\nby O\nVancouver B-ORG\nafter O\ncolliding O\nwith O\nGalley B-PER\nin O\nBuffalo B-ORG\nzone O\n. O\n\nGalley B-PER\nsuffered O\na O\nconcussion O\nand O\ndid O\nnot O\nreturn O\nto O\nthe O\ngame O\n. O\n\n\" O\nMr O\nBure B-PER\nleft O\nhis O\nfeet O\nto O\ndeliver O\na O\nforearm O\nblow O\nto O\nMr O\nGalley B-PER\nas O\nhe O\nwas O\nabout O\nto O\nbe O\nchecked O\nlegally O\nby O\nhis O\nopponent O\n, O\n\" O\nsaid O\nNHL B-ORG\ndiscipline O\nchief O\nBrian B-PER\nBurke I-PER\nin O\nhanding O\nout O\nthe O\nsuspension O\n. O\n\n\" O\nAlthough O\nit O\nis O\nclear O\nfrom O\nthe O\nvideotape O\nthat O\nMr O\nBure B-PER\n's O\nactions O\nwere O\na O\nreaction O\nto O\nthe O\nimpending O\nhit O\nand O\nthere O\nwas O\nno O\nintent O\nto O\ninjure O\nhis O\nopponent O\n, O\nthere O\ncan O\nbe O\nno O\nexcuse O\nfor O\nthis O\ntype O\nof O\nconduct O\n, O\n\" O\nBurke B-PER\nsaid O\n. O\n\nBure B-PER\n, O\nwho O\nis O\nstruggling O\nwith O\nonly O\nnine O\ngoals O\nand O\n12 O\nassists O\nin O\n26 O\ngames O\n, O\nwill O\nmiss O\nSaturday O\n's O\nhome O\ngame O\nagainst O\nOttawa B-ORG\n. O\n\n-DOCSTART- O\n\nBOXING O\n- O\nSCHULZ B-PER\nDEFEATS O\nRIBALTA B-PER\nIN O\nIBF B-ORG\nHEAVYWEIGHT O\nFIGHT O\n. O\n\nVIENNA B-LOC\n1996-12-07 O\n\nGerman B-MISC\nAxel B-PER\nSchulz I-PER\noutpointed O\nCuba B-LOC\n's O\nJose B-PER\nRibalta I-PER\nin O\ntheir O\nInternational B-ORG\nBoxing I-ORG\nFederation I-ORG\nnon-title O\n10-round O\nheavyweight O\nfight O\non O\nSaturday O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSPANISH B-MISC\nFIRST O\nDIVISION O\nSUMMARY O\n. O\n\nMADRID B-LOC\n1996-12-07 O\n\nSummary O\nof O\nSaturday O\n's O\nSpanish B-MISC\nfirst O\ndivision O\nmatch O\n: O\n\nReal B-ORG\nMadrid I-ORG\n2 O\n( O\nDavor B-PER\nSuker I-PER\n24 O\n, O\nPredrag B-PER\nMijatovic I-PER\n48 O\n) O\nBarcelona B-ORG\n0 O\n. O\n\nHalftime O\n1-0 O\n. O\n\nAttendance O\n106,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBALKAN B-LOC\nSTRIKE O\nFORCE O\nWIN O\nOLD O\nFIRM O\nGAME O\nFOR O\nREAL B-ORG\n. O\n\nMADRID B-LOC\n1996-12-07 O\n\nReal B-ORG\nMadrid I-ORG\n's O\nBalkan B-LOC\nstrike O\nforce O\nof O\nDavor B-PER\nSuker I-PER\nand O\nPredrag B-PER\nMijatovic I-PER\nshot O\ntheir O\nside O\nto O\na O\n2-0 O\nwin O\nover O\nBarcelona B-ORG\nin O\nSpain B-LOC\n's O\nold O\nfirm O\ngame O\non O\nSaturday O\n. O\n\nThe O\nresult O\nleaves O\nReal B-ORG\non O\n38 O\npoints O\nafter O\n16 O\ngames O\n, O\nfour O\nahead O\nof O\nBarcelona B-ORG\n. O\n\nWith O\njust O\none O\nleague O\nmatch O\nscheduled O\nbefore O\nthe O\nNew O\nYear O\nbreak O\n, O\nReal B-ORG\nare O\nalso O\nassured O\nof O\nspending O\nChristmas O\nahead O\nof O\ntheir O\narch-rivals O\n. O\n\nA O\nmix-up O\nin O\nthe O\nBarcelona B-ORG\ndefence O\nlet O\nCroatian B-MISC\ninternational O\nSuker B-PER\nin O\nmidway O\nthrough O\nthe O\nfirst O\nhalf O\n, O\nand O\nMontenegrin B-MISC\nstriker O\nMijatovic B-PER\nmade O\nit O\n2-0 O\nafter O\nfine O\nwork O\nby O\nClarence B-PER\nSeedorf I-PER\njust O\nafter O\nthe O\nbreak O\n. O\n\nBarcelona B-ORG\nfought O\nback O\nstrongly O\nbut O\nwere O\ntwice O\ndenied O\nby O\nthe O\nwoodwork O\non O\nan O\nunusually O\nquiet O\nnight O\nfor O\nBrazilian B-MISC\nstriker O\nRonaldo B-PER\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPSV B-ORG\nHIT O\nVOLENDAM B-ORG\nFOR O\nSIX O\n. O\n\nAMSTERDAM B-LOC\n1996-12-07 O\n\nBrazilian B-MISC\nstriker O\nMarcelo B-PER\nand O\nYugoslav B-MISC\nmidfielder O\nZeljko B-PER\nPetrovic I-PER\neach O\nscored O\ntwice O\nas O\nDutch B-MISC\nfirst O\ndivision O\nleaders O\nPSV B-ORG\nEindhoven I-ORG\nromped O\nto O\na O\n6-0 O\nwin O\nover O\nVolendam B-ORG\non O\nSaturday O\n. O\n\nTheir O\nother O\nmarksmen O\nwere O\nBrazilian B-MISC\ndefender O\nVampeta B-PER\nand O\nBelgian B-MISC\nstriker O\nLuc B-PER\nNilis I-PER\n, O\nhis O\n14th O\nof O\nthe O\nseason O\n. O\n\nPSV B-ORG\n, O\nwell O\non O\nthe O\nway O\nto O\ntheir O\n14th O\nleague O\ntitle O\n, O\noutgunned O\nVolendam B-ORG\nin O\nevery O\ndepartment O\nof O\nthe O\ngame O\n. O\n\nThey O\nboast O\na O\nnine-point O\nlead O\nover O\nFeyenoord B-ORG\n, O\nwho O\nhave O\ntwo O\ngames O\nin O\nhand O\n, O\nand O\nare O\n16 O\npoints O\nclear O\nof O\nchampions O\nAjax B-ORG\nAmsterdam I-ORG\n, O\nwho O\nhave O\nplayed O\n18 O\nmatches O\ncompared O\nto O\nPSV B-ORG\n's O\n19 O\n. O\n\nAjax B-ORG\nface O\nAZ B-ORG\nAlkmaar I-ORG\naway O\non O\nSunday O\nand O\nFeyenoord B-ORG\n, O\neliminated O\nfrom O\nthe O\nUEFA B-MISC\nCup I-MISC\nafter O\nlosing O\n4-2 O\non O\naggregate O\nto O\nTenerife B-ORG\non O\nTuesday O\n, O\ntravel O\nto O\nDe B-ORG\nGraafschap I-ORG\nDoetinchem I-ORG\n. O\n\nThe O\nDoetinchem B-ORG\nside O\n, O\ndubbed O\n\" O\nThe B-ORG\nSuper I-ORG\nPeasants I-ORG\n\" O\n, O\nare O\none O\nof O\nthe O\nsurprise O\npackages O\nof O\nthe O\nseason O\n. O\n\nThey O\nare O\nfourth O\nin O\nthe O\ntable O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSPANISH B-MISC\nFIRST O\nDIVISION O\nRESULT O\n/ O\nSTANDINGS O\n. O\n\nMADRID B-LOC\n1996-12-07 O\n\nResult O\nof O\nSaturday O\n's O\nonly O\nSpanish B-MISC\n\nfirst O\ndivision O\nmatch O\n: O\n\nReal B-ORG\nMadrid I-ORG\n2 O\nBarcelona B-ORG\n0 O\n\nStandings O\n( O\ntabulate O\nunder O\ngames O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\n\ngoals O\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nReal B-ORG\nMadrid I-ORG\n16 O\n11 O\n5 O\n0 O\n32 O\n12 O\n38 O\n\nBarcelona B-ORG\n16 O\n10 O\n4 O\n2 O\n46 O\n21 O\n34 O\n\nDeportivo B-ORG\nCoruna I-ORG\n15 O\n9 O\n6 O\n0 O\n23 O\n7 O\n33 O\n\nReal B-ORG\nBetis I-ORG\n15 O\n8 O\n5 O\n2 O\n28 O\n13 O\n29 O\n\nAtletico B-ORG\nMadrid I-ORG\n15 O\n8 O\n3 O\n4 O\n26 O\n17 O\n27 O\n\nAthletic B-ORG\nBilbao I-ORG\n15 O\n7 O\n4 O\n4 O\n28 O\n22 O\n25 O\n\nReal B-ORG\nSociedad I-ORG\n15 O\n7 O\n3 O\n5 O\n20 O\n18 O\n24 O\n\nValladolid B-ORG\n15 O\n7 O\n3 O\n5 O\n19 O\n18 O\n24 O\n\nRacing B-ORG\nSantander I-ORG\n15 O\n5 O\n7 O\n3 O\n15 O\n15 O\n22 O\n\nRayo B-ORG\nVallecano I-ORG\n15 O\n5 O\n5 O\n5 O\n21 O\n19 O\n20 O\n\nValencia B-ORG\n15 O\n6 O\n2 O\n7 O\n23 O\n22 O\n20 O\n\nCelta B-ORG\nVigo I-ORG\n15 O\n5 O\n5 O\n5 O\n17 O\n17 O\n20 O\n\nTenerife B-ORG\n15 O\n5 O\n4 O\n6 O\n23 O\n17 O\n19 O\n\nEspanyol B-ORG\n15 O\n4 O\n4 O\n7 O\n17 O\n20 O\n16 O\n\nOviedo B-ORG\n15 O\n4 O\n4 O\n7 O\n17 O\n21 O\n16 O\n\nSporting B-ORG\nGijon O\n15 O\n4 O\n4 O\n7 O\n15 O\n22 O\n16 O\n\nLogrones B-ORG\n15 O\n4 O\n3 O\n8 O\n11 O\n33 O\n15 O\n\nZaragoza B-ORG\n15 O\n2 O\n8 O\n5 O\n18 O\n23 O\n14 O\n\nSevilla B-ORG\n15 O\n4 O\n2 O\n9 O\n13 O\n20 O\n14 O\n\nCompostela B-ORG\n15 O\n3 O\n4 O\n8 O\n13 O\n28 O\n13 O\n\nHercules B-ORG\n15 O\n2 O\n2 O\n11 O\n11 O\n29 O\n8 O\n\nExtremadura B-ORG\n15 O\n1 O\n3 O\n11 O\n8 O\n30 O\n6 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISHMAN B-MISC\nCHARLTON B-PER\nIS O\nMADE O\nAN O\nHONORARY O\nIRISHMAN B-MISC\n. O\n\nDUBLIN B-LOC\n1996-12-07 O\n\nJack B-PER\nCharlton I-PER\n's O\nrelationship O\nwith O\nthe O\npeople O\nof O\nIreland B-LOC\nwas O\ncemented O\non O\nSaturday O\nwhen O\nthe O\nEnglishman B-MISC\nwas O\nofficially O\ndeclared O\none O\nof O\ntheir O\nown O\n. O\n\nCharlton B-PER\n, O\n61 O\n, O\nand O\nhis O\nwife O\n, O\nPeggy B-PER\n, O\nbecame O\ncitizens O\nof O\nIreland B-LOC\nwhen O\nthey O\nformally O\nreceived O\nIrish B-MISC\npassports O\nfrom O\ndeputy O\nPrime O\nMinister O\nDick B-PER\nSpring I-PER\nwho O\nsaid O\nthe O\nhonour O\nhad O\nbeen O\nmade O\nin O\nrecognition O\nof O\nCharlton B-PER\n's O\nachievements O\nas O\nthe O\nnational O\nsoccer O\nmanager O\n. O\n\n\" O\nThe O\nyears O\nI O\nspent O\nas O\nmanager O\nof O\nthe O\nRepublic B-LOC\nof I-LOC\nIreland I-LOC\nwere O\nthe O\nbest O\nyears O\nof O\nmy O\nlife O\n. O\n\nIt O\nall O\nculminated O\nin O\nthe O\nfact O\nthat O\nI O\nnow O\nhave O\nlots O\nof O\ngreat O\n, O\ngreat O\nfriends O\nin O\nIreland B-LOC\n. O\n\nThat O\nis O\nwhy O\nthis O\nis O\nso O\nemotional O\na O\nnight O\nfor O\nme O\n, O\n\" O\nCharlton B-PER\nsaid O\n. O\n\n\" O\nIt O\nwas O\nthe O\njoy O\nthat O\nwe O\nall O\nhad O\nover O\nthe O\nperiod O\n, O\nthat O\nI O\nshared O\nwith O\npeople O\nthat O\nI O\ngrew O\nto O\nlove O\n, O\nthat O\nI O\ntreasure O\nmost O\n, O\n\" O\nhe O\nadded O\n. O\n\nCharlton B-PER\nmanaged O\nIreland B-LOC\nfor O\n93 O\nmatches O\n, O\nduring O\nwhich O\ntime O\nthey O\nlost O\nonly O\n17 O\ntimes O\nin O\nalmost O\n10 O\nyears O\nuntil O\nhe O\nresigned O\nin O\nDecember O\n1995 O\n. O\n\nHe O\nguided O\nIreland B-LOC\nto O\ntwo O\nsuccessive O\nWorld B-MISC\nCup I-MISC\nfinals O\ntournaments O\nand O\nto O\nthe O\n1988 O\nEuropean B-MISC\nchampionship O\nfinals O\nin O\nGermany B-LOC\n, O\nafter O\nthe O\nIrish B-MISC\nbeat O\na O\nwell-fancied O\nEngland B-LOC\nteam O\n1-0 O\nin O\ntheir O\ngroup O\nqualifier O\n. O\n\nThe O\nlanky O\nformer O\nLeeds B-ORG\nUnited I-ORG\ndefender O\ndid O\nnot O\nmake O\nhis O\nEngland B-LOC\ndebut O\nuntil O\nthe O\nage O\nof O\n30 O\nbut O\neventually O\nwon O\n35 O\ncaps O\nand O\nwas O\na O\nkey O\nmember O\nof O\nthe O\n1966 B-MISC\nWorld I-MISC\nCup I-MISC\nwinning O\nteam O\nwith O\nhis O\nyounger O\nbrother O\n, O\nBobby B-PER\n. O\n\n"
  },
  {
    "path": "dataset/CONLL/train.txt",
    "content": "EU B-ORG\nrejects O\nGerman B-MISC\ncall O\nto O\nboycott O\nBritish B-MISC\nlamb O\n. O\n\nPeter B-PER\nBlackburn I-PER\n\nBRUSSELS B-LOC\n1996-08-22 O\n\nThe O\nEuropean B-ORG\nCommission I-ORG\nsaid O\non O\nThursday O\nit O\ndisagreed O\nwith O\nGerman B-MISC\nadvice O\nto O\nconsumers O\nto O\nshun O\nBritish B-MISC\nlamb O\nuntil O\nscientists O\ndetermine O\nwhether O\nmad O\ncow O\ndisease O\ncan O\nbe O\ntransmitted O\nto O\nsheep O\n. O\n\nGermany B-LOC\n's O\nrepresentative O\nto O\nthe O\nEuropean B-ORG\nUnion I-ORG\n's O\nveterinary O\ncommittee O\nWerner B-PER\nZwingmann I-PER\nsaid O\non O\nWednesday O\nconsumers O\nshould O\nbuy O\nsheepmeat O\nfrom O\ncountries O\nother O\nthan O\nBritain B-LOC\nuntil O\nthe O\nscientific O\nadvice O\nwas O\nclearer O\n. O\n\n\" O\nWe O\ndo O\nn't O\nsupport O\nany O\nsuch O\nrecommendation O\nbecause O\nwe O\ndo O\nn't O\nsee O\nany O\ngrounds O\nfor O\nit O\n, O\n\" O\nthe O\nCommission B-ORG\n's O\nchief O\nspokesman O\nNikolaus B-PER\nvan I-PER\nder I-PER\nPas I-PER\ntold O\na O\nnews O\nbriefing O\n. O\n\nHe O\nsaid O\nfurther O\nscientific O\nstudy O\nwas O\nrequired O\nand O\nif O\nit O\nwas O\nfound O\nthat O\naction O\nwas O\nneeded O\nit O\nshould O\nbe O\ntaken O\nby O\nthe O\nEuropean B-ORG\nUnion I-ORG\n. O\n\nHe O\nsaid O\na O\nproposal O\nlast O\nmonth O\nby O\nEU B-ORG\nFarm O\nCommissioner O\nFranz B-PER\nFischler I-PER\nto O\nban O\nsheep O\nbrains O\n, O\nspleens O\nand O\nspinal O\ncords O\nfrom O\nthe O\nhuman O\nand O\nanimal O\nfood O\nchains O\nwas O\na O\nhighly O\nspecific O\nand O\nprecautionary O\nmove O\nto O\nprotect O\nhuman O\nhealth O\n. O\n\nFischler B-PER\nproposed O\nEU-wide B-MISC\nmeasures O\nafter O\nreports O\nfrom O\nBritain B-LOC\nand O\nFrance B-LOC\nthat O\nunder O\nlaboratory O\nconditions O\nsheep O\ncould O\ncontract O\nBovine B-MISC\nSpongiform I-MISC\nEncephalopathy I-MISC\n( O\nBSE B-MISC\n) O\n-- O\nmad O\ncow O\ndisease O\n. O\n\nBut O\nFischler B-PER\nagreed O\nto O\nreview O\nhis O\nproposal O\nafter O\nthe O\nEU B-ORG\n's O\nstanding O\nveterinary O\ncommittee O\n, O\nmational O\nanimal O\nhealth O\nofficials O\n, O\nquestioned O\nif O\nsuch O\naction O\nwas O\njustified O\nas O\nthere O\nwas O\nonly O\na O\nslight O\nrisk O\nto O\nhuman O\nhealth O\n. O\n\nSpanish B-MISC\nFarm O\nMinister O\nLoyola B-PER\nde I-PER\nPalacio I-PER\nhad O\nearlier O\naccused O\nFischler B-PER\nat O\nan O\nEU B-ORG\nfarm O\nministers O\n' O\nmeeting O\nof O\ncausing O\nunjustified O\nalarm O\nthrough O\n\" O\ndangerous O\ngeneralisation O\n. O\n\" O\n\n. O\n\nOnly O\nFrance B-LOC\nand O\nBritain B-LOC\nbacked O\nFischler B-PER\n's O\nproposal O\n. O\n\nThe O\nEU B-ORG\n's O\nscientific O\nveterinary O\nand O\nmultidisciplinary O\ncommittees O\nare O\ndue O\nto O\nre-examine O\nthe O\nissue O\nearly O\nnext O\nmonth O\nand O\nmake O\nrecommendations O\nto O\nthe O\nsenior O\nveterinary O\nofficials O\n. O\n\nSheep O\nhave O\nlong O\nbeen O\nknown O\nto O\ncontract O\nscrapie O\n, O\na O\nbrain-wasting O\ndisease O\nsimilar O\nto O\nBSE B-MISC\nwhich O\nis O\nbelieved O\nto O\nhave O\nbeen O\ntransferred O\nto O\ncattle O\nthrough O\nfeed O\ncontaining O\nanimal O\nwaste O\n. O\n\nBritish B-MISC\nfarmers O\ndenied O\non O\nThursday O\nthere O\nwas O\nany O\ndanger O\nto O\nhuman O\nhealth O\nfrom O\ntheir O\nsheep O\n, O\nbut O\nexpressed O\nconcern O\nthat O\nGerman B-MISC\ngovernment O\nadvice O\nto O\nconsumers O\nto O\navoid O\nBritish B-MISC\nlamb O\nmight O\ninfluence O\nconsumers O\nacross O\nEurope B-LOC\n. O\n\n\" O\nWhat O\nwe O\nhave O\nto O\nbe O\nextremely O\ncareful O\nof O\nis O\nhow O\nother O\ncountries O\nare O\ngoing O\nto O\ntake O\nGermany B-LOC\n's O\nlead O\n, O\n\" O\nWelsh B-ORG\nNational I-ORG\nFarmers I-ORG\n' I-ORG\nUnion I-ORG\n( O\nNFU B-ORG\n) O\nchairman O\nJohn B-PER\nLloyd I-PER\nJones I-PER\nsaid O\non O\nBBC B-ORG\nradio I-ORG\n. O\n\nBonn B-LOC\nhas O\nled O\nefforts O\nto O\nprotect O\npublic O\nhealth O\nafter O\nconsumer O\nconfidence O\ncollapsed O\nin O\nMarch O\nafter O\na O\nBritish B-MISC\nreport O\nsuggested O\nhumans O\ncould O\ncontract O\nan O\nillness O\nsimilar O\nto O\nmad O\ncow O\ndisease O\nby O\neating O\ncontaminated O\nbeef O\n. O\n\nGermany B-LOC\nimported O\n47,600 O\nsheep O\nfrom O\nBritain B-LOC\nlast O\nyear O\n, O\nnearly O\nhalf O\nof O\ntotal O\nimports O\n. O\n\nIt O\nbrought O\nin O\n4,275 O\ntonnes O\nof O\nBritish B-MISC\nmutton O\n, O\nsome O\n10 O\npercent O\nof O\noverall O\nimports O\n. O\n\n-DOCSTART- O\n\nRare O\nHendrix B-PER\nsong O\ndraft O\nsells O\nfor O\nalmost O\n$ O\n17,000 O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nA O\nrare O\nearly O\nhandwritten O\ndraft O\nof O\na O\nsong O\nby O\nU.S. B-LOC\nguitar O\nlegend O\nJimi B-PER\nHendrix I-PER\nwas O\nsold O\nfor O\nalmost O\n$ O\n17,000 O\non O\nThursday O\nat O\nan O\nauction O\nof O\nsome O\nof O\nthe O\nlate O\nmusician O\n's O\nfavourite O\npossessions O\n. O\n\nA O\nFlorida B-LOC\nrestaurant O\npaid O\n10,925 O\npounds O\n( O\n$ O\n16,935 O\n) O\nfor O\nthe O\ndraft O\nof O\n\" O\nAi B-MISC\nn't I-MISC\nno I-MISC\ntelling I-MISC\n\" O\n, O\nwhich O\nHendrix B-PER\npenned O\non O\na O\npiece O\nof O\nLondon B-LOC\nhotel O\nstationery O\nin O\nlate O\n1966 O\n. O\n\nAt O\nthe O\nend O\nof O\na O\nJanuary O\n1967 O\nconcert O\nin O\nthe O\nEnglish B-MISC\ncity O\nof O\nNottingham B-LOC\nhe O\nthrew O\nthe O\nsheet O\nof O\npaper O\ninto O\nthe O\naudience O\n, O\nwhere O\nit O\nwas O\nretrieved O\nby O\na O\nfan O\n. O\n\nBuyers O\nalso O\nsnapped O\nup O\n16 O\nother O\nitems O\nthat O\nwere O\nput O\nup O\nfor O\nauction O\nby O\nHendrix B-PER\n's O\nformer O\ngirlfriend O\nKathy B-PER\nEtchingham I-PER\n, O\nwho O\nlived O\nwith O\nhim O\nfrom O\n1966 O\nto O\n1969 O\n. O\n\nThey O\nincluded O\na O\nblack O\nlacquer O\nand O\nmother O\nof O\npearl O\ninlaid O\nbox O\nused O\nby O\nHendrix B-PER\nto O\nstore O\nhis O\ndrugs O\n, O\nwhich O\nan O\nanonymous O\nAustralian B-MISC\npurchaser O\nbought O\nfor O\n5,060 O\npounds O\n( O\n$ O\n7,845 O\n) O\n. O\n\nThe O\nguitarist O\ndied O\nof O\na O\ndrugs O\noverdose O\nin O\n1970 O\naged O\n27 O\n. O\n\n-DOCSTART- O\n\nChina B-LOC\nsays O\nTaiwan B-LOC\nspoils O\natmosphere O\nfor O\ntalks O\n. O\n\nBEIJING B-LOC\n1996-08-22 O\n\nChina B-LOC\non O\nThursday O\naccused O\nTaipei B-LOC\nof O\nspoiling O\nthe O\natmosphere O\nfor O\na O\nresumption O\nof O\ntalks O\nacross O\nthe O\nTaiwan B-LOC\nStrait I-LOC\nwith O\na O\nvisit O\nto O\nUkraine B-LOC\nby O\nTaiwanese B-MISC\nVice O\nPresident O\nLien B-PER\nChan I-PER\nthis O\nweek O\nthat O\ninfuriated O\nBeijing B-LOC\n. O\n\nSpeaking O\nonly O\nhours O\nafter O\nChinese B-MISC\nstate O\nmedia O\nsaid O\nthe O\ntime O\nwas O\nright O\nto O\nengage O\nin O\npolitical O\ntalks O\nwith O\nTaiwan B-LOC\n, O\nForeign B-ORG\nMinistry I-ORG\nspokesman O\nShen B-PER\nGuofang I-PER\ntold O\nReuters B-ORG\n: O\n\" O\nThe O\nnecessary O\natmosphere O\nfor O\nthe O\nopening O\nof O\nthe O\ntalks O\nhas O\nbeen O\ndisrupted O\nby O\nthe O\nTaiwan B-LOC\nauthorities O\n. O\n\" O\n\nState O\nmedia O\nquoted O\nChina B-LOC\n's O\ntop O\nnegotiator O\nwith O\nTaipei B-LOC\n, O\nTang B-PER\nShubei I-PER\n, O\nas O\ntelling O\na O\nvisiting O\ngroup O\nfrom O\nTaiwan B-LOC\non O\nWednesday O\nthat O\nit O\nwas O\ntime O\nfor O\nthe O\nrivals O\nto O\nhold O\npolitical O\ntalks O\n. O\n\n\" O\nNow O\nis O\nthe O\ntime O\nfor O\nthe O\ntwo O\nsides O\nto O\nengage O\nin O\npolitical O\ntalks O\n... O\n\nthat O\nis O\nto O\nend O\nthe O\nstate O\nof O\nhostility O\n, O\n\" O\nThursday O\n's O\noverseas O\nedition O\nof O\nthe O\nPeople B-ORG\n's I-ORG\nDaily I-ORG\nquoted O\nTang B-PER\nas O\nsaying O\n. O\n\nThe O\nforeign O\nministry O\n's O\nShen B-ORG\ntold O\nReuters B-ORG\nTelevision I-ORG\nin O\nan O\ninterview O\nhe O\nhad O\nread O\nreports O\nof O\nTang B-PER\n's O\ncomments O\nbut O\ngave O\nno O\ndetails O\nof O\nwhy O\nthe O\nnegotiator O\nhad O\nconsidered O\nthe O\ntime O\nright O\nfor O\ntalks O\nwith O\nTaiwan B-LOC\n, O\nwhich O\nBeijing B-LOC\nconsiders O\na O\nrenegade O\nprovince O\n. O\n\nChina B-LOC\n, O\nwhich O\nhas O\nlong O\nopposed O\nall O\nTaipei B-LOC\nefforts O\nto O\ngain O\ngreater O\ninternational O\nrecognition O\n, O\nwas O\ninfuriated O\nby O\na O\nvisit O\nto O\nUkraine B-LOC\nthis O\nweek O\nby O\nTaiwanese B-MISC\nVice O\nPresident O\nLien B-PER\n. O\n\n-DOCSTART- O\n\nChina B-LOC\nsays O\ntime O\nright O\nfor O\nTaiwan B-LOC\ntalks O\n. O\n\nBEIJING B-LOC\n1996-08-22 O\n\nChina B-LOC\nhas O\nsaid O\nit O\nwas O\ntime O\nfor O\npolitical O\ntalks O\nwith O\nTaiwan B-LOC\nand O\nthat O\nthe O\nrival O\nisland O\nshould O\ntake O\npractical O\nsteps O\ntowards O\nthat O\ngoal O\n. O\n\nConsultations O\nshould O\nbe O\nheld O\nto O\nset O\nthe O\ntime O\nand O\nformat O\nof O\nthe O\ntalks O\n, O\nthe O\nofficial O\nXinhua B-ORG\nnews O\nagency O\nquoted O\nTang B-PER\nShubei I-PER\n, O\nexecutive O\nvice O\nchairman O\nof O\nthe O\nAssociation B-ORG\nfor I-ORG\nRelations I-ORG\nAcross I-ORG\nthe I-ORG\nTaiwan I-ORG\nStraits I-ORG\n, O\nas O\nsaying O\nlate O\non O\nWednesday O\n. O\n\n-DOCSTART- O\n\nGerman B-MISC\nJuly O\ncar O\nregistrations O\nup O\n14.2 O\npct O\nyr O\n/ O\nyr O\n. O\n\nFRANKFURT B-LOC\n1996-08-22 O\n\nGerman B-MISC\nfirst-time O\nregistrations O\nof O\nmotor O\nvehicles O\njumped O\n14.2 O\npercent O\nin O\nJuly O\nthis O\nyear O\nfrom O\nthe O\nyear-earlier O\nperiod O\n, O\nthe O\nFederal B-ORG\noffice I-ORG\nfor I-ORG\nmotor I-ORG\nvehicles I-ORG\nsaid O\non O\nThursday O\n. O\n\nThe O\noffice O\nsaid O\n356,725 O\nnew O\ncars O\nwere O\nregistered O\nin O\nJuly O\n1996 O\n-- O\n304,850 O\npassenger O\ncars O\nand O\n15,613 O\ntrucks O\n. O\n\nThe O\nfigures O\nrepresent O\na O\n13.6 O\npercent O\nincrease O\nfor O\npassenger O\ncars O\nand O\na O\n2.2 O\npercent O\ndecline O\nfor O\ntrucks O\nfrom O\nJuly O\n1995 O\n. O\n\nMotor-bike O\nregistration O\nrose O\n32.7 O\npercent O\nin O\nthe O\nperiod O\n. O\n\nThe O\ngrowth O\nwas O\npartly O\ndue O\nto O\nan O\nincreased O\nnumber O\nof O\nGermans B-MISC\nbuying O\nGerman B-MISC\ncars O\nabroad O\n, O\nwhile O\nmanufacturers O\nsaid O\nthat O\ndomestic O\ndemand O\nwas O\nweak O\n, O\nthe O\nfederal O\noffice O\nsaid O\n. O\n\nAlmost O\nall O\nGerman B-MISC\ncar O\nmanufacturers O\nposted O\ngains O\nin O\nregistration O\nnumbers O\nin O\nthe O\nperiod O\n. O\n\nVolkswagen B-ORG\nAG I-ORG\nwon O\n77,719 O\nregistrations O\n, O\nslightly O\nmore O\nthan O\na O\nquarter O\nof O\nthe O\ntotal O\n. O\n\nOpel B-ORG\nAG I-ORG\ntogether O\nwith O\nGeneral B-ORG\nMotors I-ORG\ncame O\nin O\nsecond O\nplace O\nwith O\n49,269 O\nregistrations O\n, O\n16.4 O\npercent O\nof O\nthe O\noverall O\nfigure O\n. O\n\nThird O\nwas O\nFord B-ORG\nwith O\n35,563 O\nregistrations O\n, O\nor O\n11.7 O\npercent O\n. O\n\nOnly O\nSeat B-ORG\nand O\nPorsche B-ORG\nhad O\nfewer O\nregistrations O\nin O\nJuly O\n1996 O\ncompared O\nto O\nlast O\nyear O\n's O\nJuly O\n. O\n\nSeat B-ORG\nposted O\n3,420 O\nregistrations O\ncompared O\nwith O\n5522 O\nregistrations O\nin O\nJuly O\na O\nyear O\nearlier O\n. O\n\nPorsche B-ORG\n's O\nregistrations O\nfell O\nto O\n554 O\nfrom O\n643 O\n. O\n\n-DOCSTART- O\n\nGREEK B-MISC\nSOCIALISTS O\nGIVE O\nGREEN O\nLIGHT O\nTO O\nPM O\nFOR O\nELECTIONS O\n. O\n\nATHENS B-LOC\n1996-08-22 O\n\nThe O\nGreek B-MISC\nsocialist O\nparty O\n's O\nexecutive O\nbureau O\ngave O\nthe O\ngreen O\nlight O\nto O\nPrime O\nMinister O\nCostas B-PER\nSimitis I-PER\nto O\ncall O\nsnap O\nelections O\n, O\nits O\ngeneral O\nsecretary O\nCostas B-PER\nSkandalidis I-PER\ntold O\nreporters O\n. O\n\nPrime O\nMinister O\nCostas B-PER\nSimitis I-PER\nis O\ngoing O\nto O\nmake O\nan O\nofficial O\nannouncement O\nafter O\na O\ncabinet O\nmeeting O\nlater O\non O\nThursday O\n, O\nsaid O\nSkandalidis B-PER\n. O\n\n-- O\nDimitris B-PER\nKontogiannis I-PER\n, O\nAthens B-ORG\nNewsroom I-ORG\n+301 O\n3311812-4 O\n\n-DOCSTART- O\n\nBayerVB B-ORG\nsets O\nC$ B-MISC\n100 O\nmillion O\nsix-year O\nbond O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nThe O\nfollowing O\nbond O\nwas O\nannounced O\nby O\nlead O\nmanager O\nToronto B-PER\nDominion I-PER\n. O\n\nBORROWER O\nBAYERISCHE B-ORG\nVEREINSBANK I-ORG\n\nAMT O\nC$ B-MISC\n100 O\nMLN O\nCOUPON O\n6.625 O\nMATURITY O\n24.SEP.02 O\n\nTYPE O\nSTRAIGHT O\nISS O\nPRICE O\n100.92 O\nPAY O\nDATE O\n24.SEP.96 O\n\nFULL O\nFEES O\n1.875 O\nREOFFER O\n99.32 O\nSPREAD O\n+20 O\nBP O\n\nMOODY O\nAA1 O\nLISTING O\nLUX O\nPAY O\nFREQ O\n= O\n\nS&P B-ORG\n= O\nDENOMS O\n( O\nK O\n) O\n1-10-100 O\nSALE O\nLIMITS O\nUS B-LOC\n/ O\nUK B-LOC\n/ O\nCA B-LOC\n\nNEG O\nPLG O\nNO O\nCRS O\nDEFLT O\nNO O\nFORCE O\nMAJ O\n= O\n\nGOV O\nLAW O\nGERMAN B-MISC\nHOME O\nCTRY O\n= O\nTAX O\nPROVS O\nSTANDARD O\n\nMGT O\n/ O\nUND O\n0.275 O\nSELL O\nCONC O\n1.60 O\nPRAECIP O\n= O\n\nUNDERLYING O\nGOVT O\nBOND O\n7.0 O\nPCT O\nSEPT O\n2001 O\n\nNOTES O\nBAYERISCHE B-ORG\nVEREINSBANK I-ORG\nIS O\nJOINT O\nLEAD O\nMANAGER O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n7658 O\n\n-DOCSTART- O\n\nVenantius B-ORG\nsets O\n$ O\n300 O\nmillion O\nJanuary O\n1999 O\nFRN O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nThe O\nfollowing O\nfloating-rate O\nissue O\nwas O\nannounced O\nby O\nlead O\nmanager O\nLehman B-ORG\nBrothers I-ORG\nInternational I-ORG\n. O\n\nBORROWER O\nVENANTIUS B-ORG\nAB I-ORG\n( O\nSWEDISH B-MISC\nNATIONAL O\nMORTGAGE O\nAGENCY O\n) O\n\nAMT O\n$ O\n300 O\nMLN O\nSPREAD O\n- O\n12.5 O\nBP O\nMATURITY O\n21.JAN.99 O\n\nTYPE O\nFRN O\nBASE O\n3M B-ORG\nLIBOR O\nPAY O\nDATE O\nS23.SEP.96 O\n\nLAST O\nMOODY O\nAA3 O\nISS O\nPRICE O\n99.956 O\nFULL O\nFEES O\n10 O\nBP O\n\nLAST O\nS&P B-ORG\nAA+ O\nREOFFER O\n= O\n\nNOTES O\nS O\nSHORT O\nFIRST O\nCOUPON O\n\nLISTING O\nLONDON B-LOC\nDENOMS O\n( O\nK O\n) O\n1-10-100 O\nSALE O\nLIMITS O\nUS B-LOC\n/ O\nUK B-LOC\n/ O\nJP B-LOC\n/ O\nFR B-LOC\n\nNEG O\nPLG O\nYES O\nCRS O\nDEFLT O\nNO O\nFORCE O\nMAJ O\nIPMA O\n2 O\n\nGOV O\nLAW O\nENGLISH B-MISC\nHOME O\nCTRY O\nSWEDEN B-LOC\nTAX O\nPROVS O\nSTANDARD O\n\nMGT O\n/ O\nUND O\n5 O\nBP O\nSELL O\nCONC O\n5 O\nBP O\nPRAECIP O\n= O\n\nNOTES O\nISSUED O\nOFF O\nEMTN O\nPROGRAMME O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n8863 O\n\n-DOCSTART- O\n\nPort O\nconditions O\nupdate O\n- O\nSyria B-LOC\n- O\nLloyds B-ORG\nShipping I-ORG\n. O\n\nPort O\nconditions O\nfrom O\nLloyds B-ORG\nShipping I-ORG\nIntelligence I-ORG\nService I-ORG\n-- O\n\nLATTAKIA B-LOC\n, O\nAug O\n10 O\n- O\nwaiting O\ntime O\nat O\nLattakia B-LOC\nand O\nTartous B-LOC\npresently O\n24 O\nhours O\n. O\n\n-DOCSTART- O\n\nIsrael B-LOC\nplays O\ndown O\nfears O\nof O\nwar O\nwith O\nSyria B-LOC\n. O\n\nColleen B-PER\nSiegel I-PER\n\nJERUSALEM B-LOC\n1996-08-22 O\n\nIsrael B-LOC\n's O\noutgoing O\npeace O\nnegotiator O\nwith O\nSyria B-LOC\nsaid O\non O\nThursday O\ncurrent O\ntensions O\nbetween O\nthe O\ntwo O\ncountries O\nappeared O\nto O\nbe O\na O\nstorm O\nin O\na O\nteacup O\n. O\n\nItamar B-PER\nRabinovich I-PER\n, O\nwho O\nas O\nIsrael B-LOC\n's O\nambassador O\nto O\nWashington B-LOC\nconducted O\nunfruitful O\nnegotiations O\nwith O\nSyria B-LOC\n, O\ntold O\nIsrael B-ORG\nRadio I-ORG\nit O\nlooked O\nlike O\nDamascus B-LOC\nwanted O\nto O\ntalk O\nrather O\nthan O\nfight O\n. O\n\n\" O\nIt O\nappears O\nto O\nme O\nthe O\nSyrian B-MISC\npriority O\nis O\nstill O\nto O\nnegotiate O\n. O\n\nThe O\nSyrians B-MISC\nare O\nconfused O\n, O\nthey O\nare O\ndefinitely O\ntense O\n, O\nbut O\nthe O\ngeneral O\nassessment O\nhere O\nin O\nWashington B-LOC\nis O\nthat O\nthis O\nis O\nessentially O\na O\nstorm O\nin O\na O\nteacup O\n, O\n\" O\nhe O\nsaid O\n. O\n\nRabinovich B-PER\nis O\nwinding O\nup O\nhis O\nterm O\nas O\nambassador O\n. O\n\nHe O\nwill O\nbe O\nreplaced O\nby O\nEliahu B-PER\nBen-Elissar I-PER\n, O\na O\nformer O\nIsraeli B-MISC\nenvoy O\nto O\nEgypt B-LOC\nand O\nright-wing O\nLikud B-ORG\nparty O\npolitician O\n. O\n\nIsrael B-LOC\non O\nWednesday O\nsent O\nSyria B-LOC\na O\nmessage O\n, O\nvia O\nWashington B-LOC\n, O\nsaying O\nit O\nwas O\ncommitted O\nto O\npeace O\nand O\nwanted O\nto O\nopen O\nnegotiations O\nwithout O\npreconditions O\n. O\n\nBut O\nit O\nslammed O\nDamascus B-LOC\nfor O\ncreating O\nwhat O\nit O\ncalled O\na O\ndangerous O\natmosphere O\n. O\n\nSyria B-LOC\naccused O\nIsrael B-LOC\non O\nWednesday O\nof O\nlaunching O\na O\nhysterical O\ncampaign O\nagainst O\nit O\nafter O\nIsraeli B-MISC\ntelevision O\nreported O\nthat O\nDamascus B-LOC\nhad O\nrecently O\ntest O\nfired O\na O\nmissile O\n. O\n\nIt O\nsaid O\nits O\narms O\npurchases O\nwere O\nfor O\ndefensive O\npurposes O\n. O\n\n\" O\nThe O\nmessage O\nthat O\nwe O\nsent O\nto O\n( O\nSyrian B-MISC\nPresident O\nHafez B-PER\nal- I-PER\n) O\nAssad B-PER\nis O\nthat O\nIsrael B-LOC\nis O\nready O\nat O\nany O\ntime O\nwithout O\npreconditions O\nto O\nenter O\npeace O\nnegotiations O\n, O\n\" O\nIsraeli B-MISC\nForeign O\nMinister O\nDavid B-PER\nLevy I-PER\ntold O\nIsrael B-ORG\nRadio I-ORG\nin O\nan O\ninterview O\n. O\n\nTension O\nhas O\nmounted O\nsince O\nIsraeli B-MISC\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\ntook O\noffice O\nin O\nJune O\nvowing O\nto O\nretain O\nthe O\nGolan B-LOC\nHeights I-LOC\nIsrael B-LOC\ncaptured O\nfrom O\nSyria B-LOC\nin O\nthe O\n1967 O\nMiddle B-LOC\nEast I-LOC\nwar O\n. O\n\nIsraeli-Syrian B-MISC\npeace O\ntalks O\nhave O\nbeen O\ndeadlocked O\nover O\nthe O\nGolan B-LOC\nsince O\n1991 O\ndespite O\nthe O\nprevious O\ngovernment O\n's O\nwillingness O\nto O\nmake O\nGolan B-LOC\nconcessions O\n. O\n\nPeace O\ntalks O\nbetween O\nthe O\ntwo O\nsides O\nwere O\nlast O\nheld O\nin O\nFebruary O\n. O\n\n\" O\nThe O\nvoices O\ncoming O\nout O\nof O\nDamascus B-LOC\nare O\nbad O\n, O\nnot O\ngood O\n. O\n\nThe O\nmedia O\n... O\n\nare O\nfull O\nof O\nexpressions O\nand O\ndeclarations O\nthat O\nmust O\nbe O\nworrying O\n... O\n\nthis O\nartificial O\natmosphere O\nis O\nvery O\ndangerous O\nbecause O\nthose O\nwho O\nspread O\nit O\ncould O\nbecome O\nits O\nprisoners O\n, O\n\" O\nLevy B-PER\nsaid O\n. O\n\n\" O\nWe O\nexpect O\nfrom O\nSyria B-LOC\n, O\nif O\nits O\nface O\nis O\nto O\npeace O\n, O\nthat O\nit O\nwill O\nanswer O\nIsrael B-LOC\n's O\nmessage O\nto O\nenter O\npeace O\nnegotiations O\nbecause O\nthat O\nis O\nour O\ngoal O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nWe O\ndo O\nnot O\nwant O\na O\nwar O\n, O\nGod B-PER\nforbid O\n. O\n\nNo O\none O\nbenefits O\nfrom O\nwars O\n. O\n\" O\n\nIsrael B-LOC\n's O\nChannel B-ORG\nTwo I-ORG\ntelevision O\nsaid O\nDamascus B-LOC\nhad O\nsent O\na O\n\" O\ncalming O\nsignal O\n\" O\nto O\nIsrael B-LOC\n. O\n\nIt O\ngave O\nno O\nsource O\nfor O\nthe O\nreport O\n. O\n\nNetanyahu B-PER\nand O\nLevy B-PER\n's O\nspokesmen O\nsaid O\nthey O\ncould O\nnot O\nconfirm O\nit O\n. O\n\nThe O\ntelevision O\nalso O\nsaid O\nthat O\nNetanyahu B-PER\nhad O\nsent O\nmessages O\nto O\nreassure O\nSyria B-LOC\nvia O\nCairo B-LOC\n, O\nthe O\nUnited B-LOC\nStates I-LOC\nand O\nMoscow B-LOC\n. O\n\n-DOCSTART- O\n\nPolish B-MISC\ndiplomat O\ndenies O\nnurses O\nstranded O\nin O\nLibya B-LOC\n. O\n\nTUNIS B-LOC\n1996-08-22 O\n\nA O\nPolish B-MISC\ndiplomat O\non O\nThursday O\ndenied O\na O\nPolish B-MISC\ntabloid O\nreport O\nthis O\nweek O\nthat O\nLibya B-LOC\nwas O\nrefusing O\nexit O\nvisas O\nto O\n100 O\nPolish B-MISC\nnurses O\ntrying O\nto O\nreturn O\nhome O\nafter O\nworking O\nin O\nthe O\nNorth B-MISC\nAfrican I-MISC\ncountry O\n. O\n\n\" O\nThis O\nis O\nnot O\ntrue O\n. O\n\nUp O\nto O\ntoday O\n, O\nwe O\nhave O\nno O\nknowledge O\nof O\nany O\nnurse O\nstranded O\nor O\nkept O\nin O\nLibya B-LOC\nwithout O\nher O\nwill O\n, O\nand O\nwe O\nhave O\nnot O\nreceived O\nany O\ncomplaint O\n, O\n\" O\nthe O\nPolish B-MISC\nembassy O\n's O\ncharge O\nd'affaires O\nin O\nTripoli B-LOC\n, O\nTadeusz B-PER\nAwdankiewicz I-PER\n, O\ntold O\nReuters B-ORG\nby O\ntelephone O\n. O\n\nPoland B-LOC\n's O\nlabour O\nministry O\nsaid O\nthis O\nweek O\nit O\nwould O\nsend O\na O\nteam O\nto O\nLibya B-LOC\nto O\ninvestigate O\n, O\nbut O\nAwdankiewicz B-PER\nsaid O\nthe O\nprobe O\nwas O\nprompted O\nby O\nsome O\nnurses O\ncomplaining O\nabout O\ntheir O\nwork O\nconditions O\nsuch O\nas O\nnon-payment O\nof O\ntheir O\nsalaries O\n. O\n\nHe O\nsaid O\nthat O\nthere O\nare O\nan O\nestimated O\n800 O\nPolish B-MISC\nnurses O\nworking O\nin O\nLibya B-LOC\n. O\n\n-DOCSTART- O\n\nTwo O\nIranian B-MISC\nopposition O\nleaders O\nmeet O\nin O\nBaghdad B-LOC\n. O\n\nHassan B-PER\nHafidh I-PER\n\nBAGHDAD B-LOC\n1996-08-22 O\n\nAn O\nIranian B-MISC\nexile O\ngroup O\nbased O\nin O\nIraq B-LOC\nvowed O\non O\nThursday O\nto O\nextend O\nsupport O\nto O\nIran B-LOC\n's O\nKurdish B-MISC\nrebels O\nafter O\nthey O\nwere O\nattacked O\nby O\nIranian B-MISC\ntroops O\ndeep O\ninside O\nIraq B-LOC\nlast O\nmonth O\n. O\n\nA O\nMujahideen B-ORG\nKhalq I-ORG\nstatement O\nsaid O\nits O\nleader O\nMassoud B-PER\nRajavi I-PER\nmet O\nin O\nBaghdad B-LOC\nthe O\nSecretary-General O\nof O\nthe O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\nof I-ORG\nIran I-ORG\n( O\nKDPI B-ORG\n) O\nHassan B-PER\nRastegar I-PER\non O\nWednesday O\nand O\nvoiced O\nhis O\nsupport O\nto O\nIran B-LOC\n's O\nrebel O\nKurds B-MISC\n. O\n\n\" O\nRajavi B-MISC\nemphasised O\nthat O\nthe O\nIranian B-MISC\nResistance B-ORG\nwould O\ncontinue O\nto O\nstand O\nside O\nby O\nside O\nwith O\ntheir O\nKurdish B-MISC\ncompatriots O\nand O\nthe O\nresistance O\nmovement O\nin O\nIranian B-LOC\nKurdistan I-LOC\n, O\n\" O\nit O\nsaid O\n. O\n\nA O\nspokesman O\nfor O\nthe O\ngroup O\nsaid O\nthe O\nmeeting O\n\" O\nsignals O\na O\nnew O\nlevel O\nof O\ncooperation O\nbetween O\nMujahideen B-ORG\nKhalq I-ORG\nand O\nthe O\nIranian B-MISC\nKurdish I-MISC\noppositions O\n\" O\n. O\n\nIran B-LOC\nheavily O\nbombarded O\ntargets O\nin O\nnorthern O\nIraq B-LOC\nin O\nJuly O\nin O\npursuit O\nof O\nKDPI B-ORG\nguerrillas O\nbased O\nin O\nIraqi B-MISC\nKurdish I-MISC\nareas O\noutside O\nthe O\ncontrol O\nof O\nthe O\ngovernment O\nin O\nBaghdad B-LOC\n. O\n\nIraqi B-MISC\nKurdish I-MISC\nareas O\nbordering O\nIran B-LOC\nare O\nunder O\nthe O\ncontrol O\nof O\nguerrillas O\nof O\nthe O\nIraqi B-ORG\nKurdish I-ORG\nPatriotic I-ORG\nUnion I-ORG\nof I-ORG\nKurdistan I-ORG\n( O\nPUK B-ORG\n) O\ngroup O\n. O\n\nPUK B-ORG\nand O\nIraq B-LOC\n's O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nKDP B-ORG\n) O\nthe O\ntwo O\nmain O\nIraqi B-MISC\nKurdish I-MISC\nfactions O\n, O\nhave O\nhad O\nnorthern O\nIraq B-LOC\nunder O\ntheir O\ncontrol O\nsince O\nIraqi B-MISC\nforces O\nwere O\nousted O\nfrom O\nKuwait B-LOC\nin O\nthe O\n1991 O\nGulf B-MISC\nWar I-MISC\n. O\n\nClashes O\nbetween O\nthe O\ntwo O\nparties O\nbroke O\nout O\nat O\nthe O\nweekend O\nin O\nthe O\nmost O\nserious O\nfighting O\nsince O\na O\nU.S.-sponsored B-MISC\nceasefire O\nlast O\nyear O\n. O\n\nMujahideen B-ORG\nKhalq I-ORG\nsaid O\nIranian B-MISC\ntroops O\nhad O\nalso O\nbeen O\nshelling O\nKDP B-ORG\npositions O\nin O\nQasri B-LOC\nregion O\nin O\nSuleimaniya B-LOC\nprovince O\nnear O\nthe O\nIranian B-MISC\nborder O\nover O\nthe O\nlast O\ntwo O\ndays O\n. O\n\nIt O\nsaid O\nabout O\n100 O\nIraqi B-MISC\nKurds I-MISC\nwere O\nkilled O\nor O\nwounded O\nin O\nthe O\nattack O\n. O\n\nBoth O\nIran B-LOC\nand O\nTurkey B-LOC\nmount O\nair O\nand O\nland O\nstrikes O\nat O\ntargets O\nin O\nnorthern O\nIraq B-LOC\nin O\npursuit O\nof O\ntheir O\nown O\nKurdish B-MISC\nrebels O\n. O\n\nA O\nU.S.-led B-MISC\nair O\nforce O\nin O\nsouthern O\nTurkey B-LOC\nprotects O\nIraqi B-MISC\nKurds I-MISC\nfrom O\npossible O\nattacks O\nby O\nBaghdad B-LOC\ntroops O\n. O\n\n-DOCSTART- O\n\nSaudi B-MISC\nriyal O\nrates O\nsteady O\nin O\nquiet O\nsummer O\ntrade O\n. O\n\nMANAMA B-LOC\n1996-08-22 O\n\nThe O\nspot O\nSaudi B-MISC\nriyal O\nagainst O\nthe O\ndollar O\nand O\nriyal O\ninterbank O\ndeposit O\nrates O\nwere O\nmainly O\nsteady O\nthis O\nweek O\nin O\nquiet O\nsummer O\ntrade O\n, O\ndealers O\nin O\nthe O\nkingdom O\nsaid O\n. O\n\n\" O\nThere O\nwere O\nno O\nchanges O\nin O\nSaudi B-MISC\nriyal O\nrates O\n. O\n\nThe O\nmarket O\nwas O\nvery O\nquiet O\nbecause O\nof O\nsummer O\nholidays O\n, O\n\" O\none O\ndealer O\nsaid O\n. O\n\nThe O\nspot O\nriyal O\nwas O\nput O\nat O\n3.7504 O\n/ O\n06 O\nto O\nthe O\ndollar O\n. O\n\nOne-month B-MISC\ninterbank O\ndeposits O\nwere O\nat O\n5-1/2 O\n, O\n3/8 O\npercent O\n, O\nthree O\nmonths O\nwere O\n5-5/8 O\n, O\n1/2 O\npercent O\nand O\nsix O\nmonths O\nwere O\n5-3/4 O\n, O\n5/8 O\npercent O\n. O\n\nOne-year B-MISC\nfunds O\nwere O\nat O\nsix O\n, O\n5-7/8 O\npercent O\n. O\n\n-DOCSTART- O\n\nIsrael B-LOC\napproves O\nArafat B-PER\n's O\nflight O\nto O\nWest B-LOC\nBank I-LOC\n. O\n\nJERUSALEM B-LOC\n1996-08-22 O\n\nIsrael B-LOC\ngave O\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\npermission O\non O\nThursday O\nto O\nfly O\nover O\nits O\nterritory O\nto O\nthe O\nWest B-LOC\nBank I-LOC\n, O\nending O\na O\nbrief O\nIsraeli-PLO B-MISC\ncrisis O\n, O\nan O\nArafat B-PER\nadviser O\nsaid O\n. O\n\n\" O\nThe O\nproblem O\nis O\nover O\n. O\n\nThe O\npresident O\n's O\naircraft O\nhas O\nreceived O\npermission O\nto O\npass O\nthrough O\nIsraeli B-MISC\nairspace O\nbut O\nthe O\npresident O\nis O\nnot O\nexpected O\nto O\ntravel O\nto O\nthe O\nWest B-LOC\nBank I-LOC\nbefore O\nMonday O\n, O\n\" O\nNabil B-PER\nAbu I-PER\nRdainah I-PER\ntold O\nReuters B-ORG\n. O\n\nArafat B-PER\nhad O\nbeen O\nscheduled O\nto O\nmeet O\nformer O\nIsraeli B-MISC\nprime O\nminister O\nShimon B-PER\nPeres I-PER\nin O\nthe O\nWest B-LOC\nBank I-LOC\ntown O\nof O\nRamallah B-LOC\non O\nThursday O\nbut O\nthe O\nvenue O\nwas O\nchanged O\nto O\nGaza B-LOC\nafter O\nIsrael B-LOC\ndenied O\nflight O\nclearance O\nto O\nthe O\nPalestinian B-MISC\nleader O\n's O\nhelicopters O\n. O\n\nPalestinian B-MISC\nofficials O\naccused O\nright-wing O\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\nof O\ntrying O\nto O\nstop O\nthe O\nRamallah B-LOC\nmeeting O\nby O\nkeeping O\nArafat B-PER\ngrounded O\n. O\n\nArafat B-PER\nsubsequently O\ncancelled O\na O\nmeeting O\nbetween O\nIsraeli B-MISC\nand O\nPLO B-ORG\nofficials O\n, O\non O\ncivilian O\naffairs O\n, O\nat O\nthe O\nAllenby B-LOC\nBridge I-LOC\ncrossing O\nbetween O\nJordan B-LOC\nand O\nthe O\nWest B-LOC\nBank I-LOC\n. O\n\nAbu B-PER\nRdainah I-PER\nsaid O\nArafat B-PER\nhad O\ndecided O\nagainst O\nflying O\nto O\nthe O\nWest B-LOC\nBank I-LOC\non O\nThursday O\n, O\nafter O\nIsrael B-LOC\nlifted O\nthe O\nban O\n, O\nbecause O\nhe O\nhad O\na O\nbusy O\nschedule O\nin O\nGaza B-LOC\nand O\nwould O\nnot O\nbe O\nfree O\nuntil O\nMonday O\n. O\n\n-DOCSTART- O\n\nArafat B-PER\nto O\nmeet O\nPeres B-PER\nin O\nGaza B-LOC\nafter O\nflight O\nban O\n. O\n\nJERUSALEM B-LOC\n1996-08-22 O\n\nYasser B-PER\nArafat I-PER\nwill O\nmeet O\nShimon B-PER\nPeres I-PER\nin O\nGaza B-LOC\non O\nThursday O\nafter O\nPalestinians B-MISC\nsaid O\nthe O\nright-wing O\nIsraeli B-MISC\ngovernment O\nhad O\nbarred O\nthe O\nPalestinian B-MISC\nleader O\nfrom O\nflying O\nto O\nthe O\nWest B-LOC\nBank I-LOC\nfor O\ntalks O\nwith O\nthe O\nformer O\nprime O\nminister O\n. O\n\n\" O\nThe O\nmeeting O\nbetween O\nPeres B-PER\nand O\nArafat B-PER\nwill O\ntake O\nplace O\nat O\nErez B-LOC\ncheckpoint O\nin O\nGaza B-LOC\nand O\nnot O\nin O\nRamallah B-LOC\nas O\nplanned O\n, O\n\" O\nPeres B-PER\n' O\noffice O\nsaid O\n. O\n\nPalestinian B-MISC\nofficials O\nsaid O\nthe O\nIsraeli B-MISC\ngovernment O\nhad O\nbarred O\nArafat B-PER\nfrom O\noverflying O\nIsrael B-LOC\nin O\na O\nPalestinian B-MISC\nhelicopter O\nto O\nthe O\nWest B-LOC\nBank I-LOC\nin O\nan O\nattempt O\nto O\nbar O\nthe O\nmeeting O\nwith O\nPeres B-PER\n. O\n\nIsraeli B-MISC\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\nhas O\naccused O\nopposition O\nleader O\nPeres B-PER\n, O\nwho O\nhe O\ndefeated O\nin O\nMay O\nelections O\n, O\nof O\ntrying O\nto O\nundermine O\nhis O\nLikud B-ORG\ngovernment O\n's O\nauthority O\nto O\nconduct O\npeace O\ntalks O\n. O\n\n-DOCSTART- O\n\nAfghan B-MISC\nUAE B-LOC\nembassy O\nsays O\nTaleban B-MISC\nguards O\ngoing O\nhome O\n. O\n\nHilary B-PER\nGush I-PER\n\nDUBAI B-LOC\n1996-08-22 O\n\nThree O\nAfghan B-MISC\nguards O\nbrought O\nto O\nthe O\nUnited B-LOC\nArab I-LOC\nEmirates I-LOC\nlast O\nweek O\nby O\nRussian B-MISC\nhostages O\nwho O\nescaped O\nfrom O\nthe O\nTaleban B-MISC\nmilitia O\nwill O\nreturn O\nto O\nAfghanistan B-LOC\nin O\na O\nfew O\ndays O\n, O\nthe O\nAfghan B-MISC\nembassy O\nin O\nAbu B-LOC\nDhabi I-LOC\nsaid O\non O\nThursday O\n. O\n\n\" O\nOur O\nambassador O\nis O\nin O\ntouch O\nwith O\nthe O\nUAE B-LOC\nforeign O\nministry O\n. O\n\nTheir O\nreturn O\nto O\nAfghanistan B-LOC\nwill O\ntake O\nplace O\nin O\ntwo O\nor O\nthree O\ndays O\n, O\n\" O\nan O\nembassy O\nofficial O\nsaid O\n. O\n\n\" O\nThe O\nembassy O\nis O\nissuing O\nthem O\ntravel O\ndocuments O\nfor O\ntheir O\nreturn O\nto O\ntheir O\nhomeland O\n. O\n\nThere O\nis O\nno O\nobjection O\nto O\ntheir O\ntravel O\n, O\n\" O\nhe O\nadded O\n. O\n\nThe O\nthree O\nIslamic B-MISC\nTaleban I-MISC\nguards O\nwere O\noverpowered O\nby O\nseven O\nRussian B-MISC\naircrew O\nwho O\nescaped O\nto O\nUAE B-LOC\nstate O\nSharjah B-LOC\nlast O\nFriday O\non O\nboard O\ntheir O\nown O\naircraft O\nafter O\na O\nyear O\nin O\nthe O\ncaptivity O\nof O\nTaleban B-MISC\nmilitia O\nin O\nKandahar B-LOC\nin O\nsouthern O\nAfghanistan B-LOC\n. O\n\nThe O\nUAE B-LOC\nsaid O\non O\nMonday O\nit O\nwould O\nhand O\nover O\nthe O\nthree O\nto O\nthe O\nInternational B-ORG\nRed I-ORG\nCrescent I-ORG\n, O\npossibly O\nlast O\nTuesday O\n. O\n\nIt O\nhas O\nsince O\nbeen O\nsilent O\non O\nthe O\nissue O\n. O\n\nWhen O\nasked O\nwhether O\nthe O\nthree O\nguards O\nwould O\ntravel O\nback O\nto O\nKandahar B-LOC\nor O\nthe O\nAfghan B-MISC\ncapital O\nKabul B-LOC\n, O\nthe O\nembassy O\nofficial O\nsaid O\n: O\n\" O\nThat O\nhas O\nnot O\nbeen O\ndecided O\n, O\nbut O\npossibly O\nKandahar B-LOC\n. O\n\" O\n\nKandahar B-LOC\nis O\nthe O\nheadquarters O\nof O\nthe O\nopposition O\nTaleban B-MISC\nmilitia O\n. O\n\nKabul B-LOC\nis O\ncontrolled O\nby O\nPresident O\nBurhanuddin B-PER\nRabbani I-PER\n's O\ngovernment O\n, O\nwhich O\nTaleban B-MISC\nis O\nfighting O\nto O\noverthrow O\n. O\n\nThe O\nembassy O\nofficial O\nsaid O\nthe O\nthree O\nmen O\n, O\nbelieved O\nto O\nbe O\nin O\ntheir O\n20s O\n, O\nwere O\ncurrently O\nin O\nAbu B-LOC\nDhabi I-LOC\n. O\n\nHe O\ndid O\nnot O\nelaborate O\n. O\n\nThe O\nRussians B-MISC\n, O\nworking O\nfor O\nthe O\nAerostan B-ORG\nfirm O\nin O\nthe O\nRussian B-MISC\nrepublic O\nof O\nTatarstan B-LOC\n, O\nwere O\ntaken O\nhostage O\nafter O\na O\nTaleban B-MISC\nMiG-19 B-MISC\nfighter O\nforced O\ntheir O\ncargo O\nplane O\nto O\nland O\nin O\nAugust O\n1995 O\n. O\n\nTaleban B-MISC\nsaid O\nits O\nshipment O\nof O\nammunition O\nfrom O\nAlbania B-LOC\nwas O\nevidence O\nof O\nRussian B-MISC\nmilitary O\nsupport O\nfor O\nRabbani B-PER\n's O\ngovernment O\n. O\n\nMoscow B-LOC\nsaid O\nthe O\ncrew O\n's O\nnationality O\nwas O\ncoincidental O\n. O\n\nNumerous O\ndiplomatic O\nattempts O\nto O\nfree O\nthe O\nseven O\nfailed O\n. O\n\nThe O\nRussians B-MISC\n, O\nwho O\nsaid O\nthey O\noverpowered O\nthe O\nguards O\n-- O\ntwo O\narmed O\nwith O\nKalashnikov B-MISC\nautomatic O\nrifles O\n-- O\nwhile O\ndoing O\nregular O\nmaintenance O\nwork O\non O\ntheir O\nIlyushin B-MISC\n76 I-MISC\ncargo O\nplane O\nlast O\nFriday O\n, O\nleft O\nthe O\nUAE B-LOC\ncapital O\nAbu B-LOC\nDhabi I-LOC\nfor O\nhome O\non O\nSunday O\n. O\n\n-DOCSTART- O\n\nIraq B-LOC\n's O\nSaddam B-PER\nmeets O\nRussia B-LOC\n's O\nZhirinovsky B-PER\n. O\n\nBAGHDAD B-LOC\n1996-08-22 O\n\nIraqi B-MISC\nPresident O\nSaddam B-PER\nHussein I-PER\nhas O\ntold O\nvisiting O\nRussian B-MISC\nultra-nationalist O\nVladimir B-PER\nZhirinovsky I-PER\nthat O\nBaghdad B-LOC\nwanted O\nto O\nmaintain O\n\" O\nfriendship O\nand O\ncooperation O\n\" O\nwith O\nMoscow B-LOC\n, O\nofficial O\nIraqi B-MISC\nnewspapers O\nsaid O\non O\nThursday O\n. O\n\n\" O\nPresident O\nSaddam B-PER\nHussein I-PER\nstressed O\nduring O\nthe O\nmeeting O\nIraq B-LOC\n's O\nkeenness O\nto O\nmaintain O\nfriendship O\nand O\ncooperation O\nwith O\nRussia B-LOC\n, O\n\" O\nthe O\npapers O\nsaid O\n. O\n\nThey O\nsaid O\nZhirinovsky B-PER\ntold O\nSaddam B-PER\nbefore O\nhe O\nleft O\nBaghdad B-LOC\non O\nWednesday O\nthat O\nhis O\nLiberal B-ORG\nDemocratic I-ORG\nparty I-ORG\nand O\nthe O\nRussian B-MISC\nDuma B-ORG\n( O\nparliament O\n) O\n\" O\nare O\ncalling O\nfor O\nan O\nimmediate O\nlifting O\nof O\nthe O\nembargo O\n\" O\nimposed O\non O\nIraq B-LOC\nafter O\nits O\n1990 O\ninvasion O\nof O\nKuwait B-LOC\n. O\n\nZhirinovsky B-PER\nsaid O\non O\nTuesday O\nhe O\nwould O\npress O\nthe O\nRussian B-MISC\ngovernment O\nto O\nhelp O\nend O\nU.N. B-ORG\ntrade O\nsanctions O\non O\nIraq B-LOC\nand O\nblamed O\nMoscow B-LOC\nfor O\ndelaying O\nestablishment O\nof O\ngood O\nties O\nwith O\nBaghdad B-LOC\n. O\n\n\" O\nOur O\nstand O\nis O\nfirm O\n, O\nnamely O\nwe O\nare O\ncalling O\non O\n( O\nthe O\nRussian B-MISC\n) O\ngovernment O\nto O\nend O\nthe O\neconomic O\nembargo O\non O\nIraq B-LOC\nand O\nresume O\ntrade O\nties O\nbetween O\nRussia B-LOC\nand O\nIraq B-LOC\n, O\n\" O\nhe O\ntold O\nreporters O\n. O\n\nZhirinovsky B-PER\nvisited O\nIraq B-LOC\ntwice O\nin O\n1995 O\n. O\n\nLast O\nOctober O\nhe O\nwas O\ninvited O\nto O\nattend O\nthe O\nreferendum O\nheld O\non O\nIraq B-LOC\n's O\npresidency O\n, O\nwhich O\nextended O\nSaddam B-PER\n's O\nterm O\nfor O\nseven O\nmore O\nyears O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nIraq B-LOC\n- O\nAug O\n22 O\n. O\n\nBAGHDAD B-LOC\n1996-08-22 O\n\nThese O\nare O\nsome O\nof O\nthe O\nleading O\nstories O\nin O\nthe O\nofficial O\nIraqi B-MISC\npress O\non O\nThursday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nTHAWRA B-ORG\n\n- O\nIraq B-LOC\n's O\nPresident O\nSaddam B-PER\nHussein I-PER\nmeets O\nwith O\nchairman O\nof O\nthe O\nRussian B-MISC\nliberal O\ndemocratic O\nparty O\nVladimir B-PER\nZhirinovsky I-PER\n. O\n\n- O\nTurkish B-MISC\nforeign O\nminister O\nsays O\nTurkey B-LOC\nwill O\ntake O\npart O\nin O\nthe O\nBaghdad B-LOC\ntrade O\nfair O\nthat O\nwill O\nbe O\nheld O\nin O\nNovember O\n. O\n\nIRAQ B-LOC\n\n- O\nA O\nshipload O\nof O\n12 O\ntonnes O\nof O\nrice O\narrives O\nin O\nUmm B-LOC\nQasr I-LOC\nport O\nin O\nthe O\nGulf B-LOC\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nLebanon B-LOC\n- O\nAug O\n22 O\n. O\n\nBEIRUT B-LOC\n1996-08-22 O\n\nThese O\nare O\nthe O\nleading O\nstories O\nin O\nthe O\nBeirut B-LOC\npress O\non O\nThursday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nAN-NAHAR B-ORG\n\n- O\nConfrontation O\nis O\nescalating O\nbetween O\nHizbollah B-ORG\nand O\nthe O\ngovernment O\n. O\n\n- O\nPrime O\nMinister O\nHariri B-PER\n: O\nIsraeli B-MISC\nthreats O\ndo O\nno O\nserve O\npeace O\n. O\n\nAS-SAFIR B-ORG\n\n- O\nParliament O\nSpeaker O\nBerri B-PER\n: O\nIsrael B-LOC\nis O\npreparing O\nfor O\nwar O\nagainst O\nSyria B-LOC\nand O\nLebanon B-LOC\n. O\n\n- O\nParliamentary O\nbattle O\nin O\nBeirut B-LOC\n.. O\n\nThe O\nthree O\nmain O\nlists O\nhave O\nbeen O\nprepared O\n. O\n\nAL-ANWAR B-ORG\n\n- O\nContinued O\ncriticism O\nof O\nlaw O\nviolation O\nincidents O\n-- O\nwhich O\noccurred O\nin O\nthe O\nMount B-LOC\nLebanon I-LOC\nelections O\nlast O\nSunday O\n. O\n\nAD-DIYAR B-ORG\n\n- O\nFinancial O\nnegotiations O\nbetween O\nLebanon B-LOC\nand O\nPakistan B-LOC\n. O\n\n- O\nHariri B-PER\nto O\nstep O\ninto O\nthe O\nelection O\nbattle O\nwith O\nan O\nincomplete O\nlist O\n. O\n\nNIDA'A B-ORG\nAL-WATAN I-ORG\n\n- O\nMaronite B-ORG\nPatriarch O\nSfeir B-PER\nexpressed O\nsorrow O\nover O\nthe O\nviolations O\nin O\nSunday O\n' O\nelections O\n. O\n\n-DOCSTART- O\n\nCME B-ORG\nlive O\nand O\nfeeder O\ncattle O\ncalls O\nrange O\nmixed O\n. O\n\nCHICAGO B-LOC\n1996-08-22 O\n\nEarly O\ncalls O\non O\nCME B-ORG\nlive O\nand O\nfeeder O\ncattle O\nfutures O\nranged O\nfrom O\n0.200 O\ncent O\nhigher O\nto O\n0.100 O\nlower O\n, O\nlivestock O\nanalysts O\nsaid O\n. O\n\nThe O\ncontinued O\nstrong O\ntone O\nto O\ncash O\ncattle O\nand O\nbeef O\nmarkets O\nshould O\nprompt O\nfurther O\nsupport O\n. O\n\nOutlook O\nfor O\na O\nbullish O\ncattle-on-feed O\nreport O\nis O\nalso O\nexpected O\nto O\nlend O\nsupport O\nand O\nprompt O\nsome O\nbull O\nspreading O\n, O\nanalysts O\nsaid O\n. O\n\nHowever O\n, O\ntrade O\nwill O\nlikely O\nbe O\nlight O\nand O\nprices O\ncould O\ndrift O\non O\nevening O\nup O\nahead O\nof O\nthe O\nreport O\n. O\n\nCash O\nmarkets O\nare O\nalso O\nexpected O\nto O\nbe O\nquiet O\nafter O\nthe O\nrecord O\namount O\nof O\nfeedlot O\ncattle O\ntraded O\nthis O\nweek O\n, O\nthey O\nsaid O\n. O\n\n-DOCSTART- O\n\nKindercare O\nsays O\ndebt O\nbuy O\nto O\nhit O\nQ1 O\nresults O\n. O\n\nMONTGOMERY B-LOC\n, O\nAla B-LOC\n. O\n\n1996-08-22 O\n\nKinderCare B-ORG\nLearning I-ORG\nCenters I-ORG\nInc I-ORG\nsaid O\non O\nThursday O\nthat O\na O\ndebt O\nbuyback O\nwould O\nmean O\nan O\nextraordinary O\nloss O\nof O\n$ O\n1.2 O\nmillion O\nin O\nits O\nfiscal O\n1997 O\nfirst O\nquarter O\n. O\n\nThe O\ncompany O\nsaid O\nthat O\nduring O\nthe O\nquarter O\n, O\nwhich O\nbegan O\nJune O\n1 O\n, O\nit O\nbought O\n$ O\n30 O\nmillion O\npar O\nvalue O\nof O\nits O\noutstanding O\n10-3/8 O\npercent O\nsenior O\nnotes O\ndue O\n2001 O\n. O\n\nThe O\nnotes O\nwere O\nbought O\nfor O\n$ O\n31.5 O\nmillion O\n. O\n\nPhilip B-PER\nMaslowe I-PER\n, O\nchief O\nfinancial O\nofficer O\nof O\nthe O\npreschool O\nand O\nchild O\ncare O\ncompany O\n, O\nsaid O\nthe O\nbuyback O\n\" O\noffered O\nan O\nopportunity O\nto O\nreduce O\nthe O\ncompany O\n's O\nweighted O\naverage O\ninterest O\ncosts O\nand O\nimprove O\nfuture O\ncash O\nflows O\nand O\nearnings O\n. O\n\" O\n\n-DOCSTART- O\n\nRESEARCH O\nALERT O\n- O\nLehman B-ORG\nstarts O\nSNET B-ORG\n. O\n\n-- O\nLehman B-ORG\nanalyst O\nBlake B-PER\nBath I-PER\nstarted O\nSouthern B-ORG\nNew I-ORG\nEngland I-ORG\nTelecommunciations I-ORG\nCorp I-ORG\nwith O\nan O\noutperform O\nrating O\n, O\nhis O\noffice O\nsaid O\n. O\n\n-- O\nThe O\nanalyst O\nset O\na O\n12-month O\nprice O\ntarget O\nof O\n$ O\n45 O\nand O\na O\nfiscal O\n1996 O\nyear O\nearnings O\nestimate O\nof O\n$ O\n3.09 O\nper O\nshare O\n, O\nhis O\noffice O\nsaid O\n. O\n\n-- O\nThe O\nanalyst O\nalso O\nset O\nan O\nearnings O\nestimate O\nfor O\nthe O\n1997 O\nyear O\n, O\nbut O\nthe O\nfigure O\nwas O\nnot O\nimmediately O\navailable O\n. O\n\n-- O\nSouthern B-ORG\nNew I-ORG\nEngland I-ORG\nclosed O\nat O\n38-1/2 O\nWednesday O\n. O\n\n-- O\nE. B-PER\nAuchard I-PER\n, O\nWall B-ORG\nStreet I-ORG\nbureau I-ORG\n, O\n212-859-1736 O\n\n-DOCSTART- O\n\nGateway B-ORG\nData I-ORG\nSciences I-ORG\nQ2 O\nnet O\nrises O\n. O\n\nPHOENIX B-LOC\n1996-08-22 O\n\nSummary O\nof O\nConsolidated B-ORG\nFinancial I-ORG\nData I-ORG\n\n( O\nIn O\nThousands O\n, O\nexcept O\nper O\nshare O\ndata O\n) O\n\nSix O\nMonths O\nEnded O\nQuarter O\nEnded O\n\nJul O\n31 O\n, O\nJul O\n31 O\n, O\nJul O\n31 O\n, O\nJul O\n31 O\n, O\n\n1996 O\n1995 O\n1996 O\n1995 O\n\nIncome O\nStatement O\nData O\n: O\n\nTotal O\nRevenue O\n$ O\n10,756 O\n$ O\n13,102 O\n$ O\n7,961 O\n$ O\n5,507 O\n\nSoftware O\nRevenue O\n2,383 O\n1,558 O\n1,086 O\n1,074 O\n\nServices O\nRevenue O\n1,154 O\n692 O\n624 O\n465 O\n\nOperating O\nIncome O\n906 O\n962 O\n599 O\n515 O\n\nNet O\nIncome O\n821 O\n512 O\n565 O\n301 O\n\nEarnings O\nPer O\nShare O\n0.31 O\n0.34 O\n0.19 O\n0.20 O\n\nJul O\n31 O\n, O\n1996 O\nJan O\n31 O\n, O\n1996 O\n\nBalance O\nSheet O\nData O\n: O\n\nWorking O\nCapital O\n$ O\n5,755 O\n( O\n$ O\n881 O\n) O\n\nCash O\nand O\nCash O\nEquivalents O\n2,386 O\n93 O\n\nTotal O\nAssets O\n14,196 O\n7,138 O\n\nShareholders O\n' O\nEquity O\n5,951 O\n( O\n1,461 O\n) O\n\n-DOCSTART- O\n\nGreek B-MISC\nsocialists O\ngive O\nPM O\ngreen O\nlight O\nfor O\nelection O\n. O\n\nATHENS B-LOC\n1996-08-22 O\n\nThe O\nGreek B-MISC\nsocialist O\nparty O\n's O\nexecutive O\nbureau O\ngave O\nPrime O\nMinister O\nCostas B-PER\nSimitis I-PER\nits O\nbacking O\nif O\nhe O\nchooses O\nto O\ncall O\nsnap O\nelections O\n, O\nits O\ngeneral O\nsecretary O\nCostas B-PER\nSkandalidis I-PER\ntold O\nreporters O\non O\nThursday O\n. O\n\nPrime O\nMinister O\nCostas B-PER\nSimitis I-PER\nwill O\nmake O\nan O\nofficial O\nannouncement O\nafter O\na O\ncabinet O\nmeeting O\nlater O\non O\nThursday O\n, O\nsaid O\nSkandalidis B-PER\n. O\n\n-- O\nDimitris B-PER\nKontogiannis I-PER\n, O\nAthens B-ORG\nNewsroom I-ORG\n+301 O\n3311812-4 O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nFrance B-LOC\n- O\nLe B-ORG\nMonde I-ORG\nAug O\n22 O\n. O\n\nPARIS B-LOC\n1996-08-22 O\n\nThese O\nare O\nleading O\nstories O\nin O\nThursday O\n's O\nafternoon O\ndaily O\nLe B-ORG\nMonde I-ORG\n, O\ndated O\nAug O\n23 O\n. O\n\nFRONT O\nPAGE O\n\n-- O\nAfricans B-MISC\nseeking O\nto O\nrenew O\nor O\nobtain O\nwork O\nand O\nresidence O\nrights O\nsay O\nPrime O\nMinister O\nAlain B-PER\nJuppe I-PER\n's O\nproposals O\nare O\ninsufficient O\nas O\nhunger O\nstrike O\nenters O\n49th O\nday O\nin O\nParis B-LOC\nchurch O\nand O\nWednesday O\nrally O\nattracts O\n8,000 O\nsympathisers O\n. O\n\n-- O\nFLNC B-ORG\nCorsican B-MISC\nnationalist O\nmovement O\nannounces O\nend O\nof O\ntruce O\nafter O\nlast O\nnight O\n's O\nattacks O\n. O\n\nBUSINESS O\nPAGES O\n\n-- O\nShutdown O\nof O\nBally B-ORG\n's O\nFrench B-MISC\nfactories O\npoints O\nup O\nshoe O\nindustry O\ncrisis O\n, O\nwith O\nFrench B-MISC\nmanufacturers O\nundercut O\nby O\nlow-wage O\ncountry O\ncompetition O\nand O\nfailure O\nto O\nkeep O\nabreast O\nof O\ntrends O\n. O\n\n-- O\nSecretary O\ngeneral O\nof O\nthe O\nSud-PTT B-MISC\ntrade O\nunion O\nat O\nFrance B-ORG\nTelecom I-ORG\nall O\nthe O\nelements O\nare O\nin O\nplace O\nfor O\nsocial O\nunrest O\nin O\nthe O\nnext O\nfew O\nweeks O\n. O\n\n-- O\nParis B-ORG\nNewsroom I-ORG\n+33 O\n1 O\n42 O\n21 O\n53 O\n81 O\n\n-DOCSTART- O\n\nWell O\nrepairs O\nto O\nlift O\nHeidrun B-LOC\noil O\noutput O\n- O\nStatoil B-ORG\n. O\n\nOSLO B-LOC\n1996-08-22 O\n\nThree O\nplugged O\nwater O\ninjection O\nwells O\non O\nthe O\nHeidrun B-LOC\noilfield O\noff O\nmid-Norway B-MISC\nwill O\nbe O\nreopened O\nover O\nthe O\nnext O\nmonth O\n, O\noperator O\nDen B-ORG\nNorske I-ORG\nStats I-ORG\nOljeselskap I-ORG\nAS I-ORG\n( O\nStatoil B-ORG\n) O\nsaid O\non O\nThursday O\n. O\n\nThe O\nplugged O\nwells O\nhave O\naccounted O\nfor O\na O\ndip O\nof O\n30,000 O\nbarrels O\nper O\nday O\n( O\nbpd O\n) O\nin O\nHeidrun B-LOC\noutput O\nto O\nroughly O\n220,000 O\nbpd O\n, O\naccording O\nto O\nthe O\ncompany O\n's O\nStatus B-ORG\nWeekly I-ORG\nnewsletter O\n. O\n\nThe O\nwells O\nwill O\nbe O\nreperforated O\nand O\ngravel O\nwill O\nbe O\npumped O\ninto O\nthe O\nreservoir O\nthrough O\none O\nof O\nthe O\nwells O\nto O\navoid O\nplugging O\nproblems O\nin O\nthe O\nfuture O\n, O\nit O\nsaid O\n. O\n\n-- O\nOslo B-LOC\nnewsroom O\n+47 O\n22 O\n42 O\n50 O\n41 O\n\n-DOCSTART- O\n\nFinnish B-MISC\nApril O\ntrade O\nsurplus O\n3.8 O\nbillion O\nmarkka O\n- O\nNCB B-ORG\n. O\n\nHELSINKI B-LOC\n1996-08-22 O\n\nFinland B-LOC\n's O\ntrade O\nsurplus O\nrose O\nto O\n3.83 O\nbillion O\nmarkka O\nin O\nApril O\nfrom O\n3.43 O\nbillion O\nin O\nMarch O\n, O\nthe O\nNational B-ORG\nCustoms I-ORG\nBoard I-ORG\n( O\nNCB B-ORG\n) O\nsaid O\nin O\na O\nstatement O\non O\nThursday O\n. O\n\nThe O\nvalue O\nof O\nexports O\nfell O\none O\npercent O\nyear-on-year O\nin O\nApril O\nand O\nthe O\nvalue O\nof O\nimports O\nfell O\ntwo O\npercent O\n, O\nNCB B-ORG\nsaid O\n. O\n\nTrade O\nbalance O\n( O\nmillion O\nmarkka O\n) O\n: O\n\nApril O\n' O\n96 O\nMarch O\n' O\n96 O\nJan-April O\n' O\n96 O\nJan-April O\n' O\n95 O\n\nImports O\n10,663 O\n10,725 O\n43,430 O\n40,989 O\n\nExports O\n14,494 O\n14,153 O\n56,126 O\n56,261 O\n\nBalance O\n+3,831 O\n+3,428 O\n+12,696 O\n+15,272 O\n\nThe O\nJanuary-April O\n1995 O\nimport O\nfigure O\nwas O\nrevised O\nfrom O\n39,584 O\nmillion O\nmarkka O\nand O\nthe O\nexport O\nfigure O\nfrom O\n55,627 O\nmillion O\nmarkka O\n. O\n\nThe O\nBank B-ORG\nof I-ORG\nFinland I-ORG\nearlier O\nestimated O\nthe O\nApril O\ntrade O\nsurplus O\nat O\n3.2 O\nbillion O\nmarkka O\nwith O\nexports O\nprojected O\nat O\n14.5 O\nbillion O\nand O\nimports O\nat O\n11.3 O\nbillion O\n. O\n\nThe O\nNCB B-ORG\n's O\nofficial O\nmonthly O\ntrade O\nstatistics O\nare O\nlagging O\nbehind O\ndue O\nto O\nchanges O\nin O\ncustoms O\nprocedures O\nwhen O\nFinland B-LOC\njoined O\nthe O\nEuropean B-ORG\nUnion I-ORG\nat O\nthe O\nstart O\nof O\n1995 O\n. O\n\n-- O\nHelsinki B-ORG\nNewsroom I-ORG\n+358 O\n- O\n0 O\n- O\n680 O\n50 O\n245 O\n\n-DOCSTART- O\n\nDutch B-MISC\nstate O\nraises O\ntap O\nsale O\nprice O\nto O\n99.95 O\n. O\n\nAMSTERDAM B-LOC\n1996-08-22 O\n\nThe O\nFinance B-ORG\nMinistry I-ORG\nraised O\nthe O\nprice O\nfor O\ntap O\nsales O\nof O\nthe O\nDutch B-MISC\ngovernment O\n's O\nnew O\n5.75 O\npercent O\nbond O\ndue O\nSeptember O\n2002 O\nto O\n99.95 O\nfrom O\n99.90 O\n. O\n\nTap O\nsales O\nbegan O\non O\nMonday O\nand O\nare O\nbeing O\nheld O\ndaily O\nfrom O\n07.00 O\nGMT B-MISC\nto O\n15.00 O\nGMT B-MISC\nuntil O\nfurther O\nnotice O\n. O\n\nThe O\nministry O\nhad O\nraised O\n2.3 O\nbillion O\nguilders O\nfrom O\nsales O\nof O\nthe O\nnew O\nbond O\nby O\nthe O\nclose O\nof O\ntrade O\non O\nWednesday O\n. O\n\n-- O\nAmsterdam B-LOC\nnewsroom O\n+31 O\n20 O\n504 O\n5000 O\n\n-DOCSTART- O\n\nGerman B-MISC\nfarm O\nministry O\ntells O\nconsumers O\nto O\navoid O\nBritish B-MISC\nmutton O\n. O\n\nBONN B-LOC\n1996-08-22 O\n\nGermany B-LOC\n's O\nAgriculture B-ORG\nMinistry I-ORG\nsuggested O\non O\nWednesday O\nthat O\nconsumers O\navoid O\neating O\nmeat O\nfrom O\nBritish B-MISC\nsheep O\nuntil O\nscientists O\ndetermine O\nwhether O\nmad O\ncow O\ndisease O\ncan O\nbe O\ntransmitted O\nto O\nthe O\nanimals O\n. O\n\n\" O\nUntil O\nthis O\nis O\ncleared O\nup O\nby O\nthe O\nEuropean B-ORG\nUnion I-ORG\n's O\nscientific O\npanels O\n-- O\nand O\nwe O\nhave O\nasked O\nthis O\nto O\nbe O\ndone O\nas O\nquickly O\nas O\npossible O\n-- O\n( O\nconsumers O\n) O\nshould O\nif O\nat O\nall O\npossible O\ngive O\npreference O\nto O\nsheepmeat O\nfrom O\nother O\ncountries O\n, O\n\" O\nministry O\nofficial O\nWerner B-PER\nZwingmann I-PER\ntold O\nZDF B-ORG\ntelevision O\n. O\n\n\" O\nI O\ndo O\nnot O\nwant O\nto O\nsay O\nthat O\nthere O\nis O\na O\nconcrete O\ndanger O\nfor O\nconsumers O\n, O\n\" O\nhe O\nadded O\n. O\n\" O\n\nThere O\nare O\ntoo O\nmany O\nholes O\nin O\nwhat O\nwe O\nknow O\n, O\nand O\nthese O\nmust O\nbe O\nfilled O\nvery O\nquickly O\n. O\n\" O\n\nBonn B-LOC\nhas O\nled O\nefforts O\nto O\nensure O\nconsumer O\nprotection O\ntops O\nthe O\nlist O\nof O\npriorities O\nin O\ndealing O\nwith O\nthe O\nmad O\ncow O\ncrisis O\n, O\nwhich O\nerupted O\nin O\nMarch O\nwhen O\nBritain B-LOC\nacknowledged O\nhumans O\ncould O\ncontract O\na O\nsimilar O\nillness O\nby O\neating O\ncontaminated O\nbeef O\n. O\n\nThe O\nEuropean B-ORG\nCommission I-ORG\nagreed O\nthis O\nmonth O\nto O\nrethink O\na O\nproposal O\nto O\nban O\nthe O\nuse O\nof O\nsuspect O\nsheep O\ntissue O\nafter O\nsome O\nEU B-ORG\nveterinary O\nexperts O\nquestioned O\nwhether O\nit O\nwas O\njustified O\n. O\n\nEU B-ORG\nFarm O\nCommissioner O\nFranz B-PER\nFischler I-PER\nhad O\nproposed O\nbanning O\nsheep O\nbrains O\n, O\nspleens O\nand O\nspinal O\ncords O\nfrom O\nthe O\nhuman O\nand O\nanimal O\nfood O\nchains O\nafter O\nreports O\nfrom O\nBritain B-LOC\nand O\nFrance B-LOC\nthat O\nunder O\nlaboratory O\nconditions O\nsheep O\ncould O\ncontract O\nBovine B-MISC\nSpongiform I-MISC\nEncephalopathy I-MISC\n( O\nBSE B-MISC\n) O\n-- O\nmad O\ncow O\ndisease O\n. O\n\nBut O\nsome O\nmembers O\nof O\nthe O\nEU B-ORG\n's O\nstanding O\nveterinary O\ncommittee O\nquestioned O\nwhether O\nthe O\naction O\nwas O\nnecessary O\ngiven O\nthe O\nslight O\nrisk O\nto O\nhuman O\nhealth O\n. O\n\nThe O\nquestion O\nis O\nbeing O\nstudied O\nseparately O\nby O\ntwo O\nEU B-ORG\nscientific O\ncommittees O\n. O\n\nSheep O\nhave O\nlong O\nbeen O\nknown O\nto O\ncontract O\nscrapie O\n, O\na O\nsimilar O\nbrain-wasting O\ndisease O\nto O\nBSE B-MISC\nwhich O\nis O\nbelieved O\nto O\nhave O\nbeen O\ntransferred O\nto O\ncattle O\nthrough O\nfeed O\ncontaining O\nanimal O\nwaste O\n. O\n\nBritish B-MISC\nofficials O\nsay O\nsheep O\nmeat O\nis O\nperfectly O\nsafe O\nto O\neat O\n. O\n\nZDF B-ORG\nsaid O\nGermany B-LOC\nimported O\n47,600 O\nsheep O\nfrom O\nBritain B-LOC\nlast O\nyear O\n, O\nnearly O\nhalf O\nof O\ntotal O\nimports O\n. O\n\nIt O\nbrought O\nin O\n4,275 O\ntonnes O\nof O\nBritish B-MISC\nmutton O\n, O\nsome O\n10 O\npercent O\nof O\noverall O\nimports O\n. O\n\nAfter O\nthe O\nBritish B-MISC\ngovernment O\nadmitted O\na O\npossible O\nlink O\nbetween O\nmad O\ncow O\ndisease O\nand O\nits O\nfatal O\nhuman O\nequivalent O\n, O\nthe O\nEU B-ORG\nimposed O\na O\nworldwide O\nban O\non O\nBritish B-MISC\nbeef O\nexports O\n. O\n\nEU B-ORG\nleaders O\nagreed O\nat O\na O\nsummit O\nin O\nJune O\nto O\na O\nprogressive O\nlifting O\nof O\nthe O\nban O\nas O\nBritain B-LOC\ntakes O\nparallel O\nmeasures O\nto O\neradicate O\nthe O\ndisease O\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nSCORES O\nAT O\nWORLD B-MISC\nSERIES I-MISC\nOF I-MISC\nGOLF I-MISC\n. O\n\nAKRON B-LOC\n, O\nOhio B-LOC\n1996-08-22 O\n\nScores O\nfrom O\nthe O\n$ O\n2.1 O\n\nmillion O\nNEC B-MISC\nWorld I-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\nafter O\nthe O\nfirst O\nround O\n\nThursday O\nat O\nthe O\n7,149 O\nyard O\n, O\npar O\n70 O\nFirestone B-LOC\nC.C I-LOC\ncourse O\n\n( O\nplayers O\nU.S. B-LOC\nunless O\nstated O\n) O\n: O\n\n66 O\nPaul B-PER\nGoydos I-PER\n, O\nBilly B-PER\nMayfair I-PER\n, O\nHidemichi B-PER\nTanaka I-PER\n( O\nJapan B-LOC\n) O\n\n68 O\nSteve B-PER\nStricker I-PER\n\n69 O\nJustin B-PER\nLeonard I-PER\n, O\nMark B-PER\nBrooks I-PER\n\n70 O\nTim B-PER\nHerron I-PER\n, O\nDuffy B-PER\nWaldorf I-PER\n, O\nDavis B-PER\nLove I-PER\n, O\nAnders B-PER\nForsbrand I-PER\n\n( O\nSweden B-LOC\n) O\n, O\nNick B-PER\nFaldo I-PER\n( O\nBritain B-LOC\n) O\n, O\nJohn B-PER\nCook I-PER\n, O\nSteve B-PER\nJones I-PER\n, O\nPhil B-PER\n\nMickelson B-PER\n, O\nGreg B-PER\nNorman I-PER\n( O\nAustralia B-LOC\n) O\n\n71 O\nErnie B-PER\nEls I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n, O\nScott B-PER\nHoch I-PER\n\n72 O\nClarence B-PER\nRose I-PER\n, O\nLoren B-PER\nRoberts I-PER\n, O\nFred B-PER\nFunk I-PER\n, O\nSven B-PER\nStruver I-PER\n\n( O\nGermany B-LOC\n) O\n, O\nAlexander B-PER\nCejka I-PER\n( O\nGermany B-LOC\n) O\n, O\nHal B-PER\nSutton I-PER\n, O\nTom B-PER\nLehman I-PER\n\n73 O\nD.A. B-PER\nWeibring I-PER\n, O\nBrad B-PER\nBryant I-PER\n, O\nCraig B-PER\nParry I-PER\n( O\nAustralia B-LOC\n) O\n, O\n\nStewart B-PER\nGinn I-PER\n( O\nAustralia B-LOC\n) O\n, O\nCorey B-PER\nPavin I-PER\n, O\nCraig B-PER\nStadler I-PER\n, O\nMark B-PER\n\nO'Meara B-PER\n, O\nFred B-PER\nCouples I-PER\n\n74 O\nPaul B-PER\nStankowski I-PER\n, O\nCostantino B-PER\nRocca I-PER\n( O\nItaly B-LOC\n) O\n\n75 O\nJim B-PER\nFuryk I-PER\n, O\nSatoshi B-PER\nHigashi I-PER\n( O\nJapan B-LOC\n) O\n, O\nWillie B-PER\nWood I-PER\n, O\nShigeki B-PER\n\nMaruyama B-PER\n( O\nJapan B-LOC\n) O\n\n76 O\nScott B-PER\nMcCarron I-PER\n\n77 O\nWayne B-PER\nWestner I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n, O\nSteve B-PER\nSchneiter I-PER\n\n79 O\nTom B-PER\nWatson I-PER\n\n81 O\nSeiki B-PER\nOkuda I-PER\n( O\nJapan B-LOC\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGLORIA B-ORG\nBISTRITA I-ORG\nBEAT O\n2-1 O\nF.C. B-ORG\nVALLETTA I-ORG\n. O\n\nBISTRITA B-LOC\n1996-08-22 O\n\nGloria B-ORG\nBistrita I-ORG\n( O\nRomania B-LOC\n) O\nbeat O\n2-1 O\n( O\nhalftime O\n1-1 O\n) O\nF.C. B-ORG\nValletta I-ORG\n( O\nMalta B-LOC\n) O\nin O\ntheir O\nCup B-MISC\nwinners I-MISC\nCup I-MISC\nmatch O\n, O\nsecond O\nleg O\nof O\nthe O\npreliminary O\nround O\n, O\non O\nThursday O\n. O\n\nScorers O\n: O\n\nGloria B-ORG\nBistrita I-ORG\n- O\nIlie B-PER\nLazar I-PER\n( O\n32nd O\n) O\n, O\nEugen B-PER\nVoica I-PER\n( O\n84th O\n) O\n\nF.C. B-ORG\nLa I-ORG\nValletta I-ORG\n- O\nGilbert B-PER\nAgius I-PER\n( O\n24th O\n) O\n\nAttendance O\n: O\n8,000 O\n\nGloria B-ORG\nBistrita I-ORG\nwon O\n4-2 O\non O\naggregate O\nand O\nqualified O\nfor O\nthe O\nfirst O\nround O\nof O\nthe O\nCup B-MISC\nwinners I-MISC\nCup I-MISC\n. O\n\nREUTER B-PER\n\n-DOCSTART- O\n\nHORSE O\nRACING O\n- O\nPIVOTAL B-PER\nENDS O\n25-YEAR O\nWAIT O\nFOR O\nTRAINER O\nPRESCOTT B-PER\n. O\n\nYORK B-LOC\n, O\nEngland B-LOC\n1996-08-22 O\n\nSir O\nMark B-PER\nPrescott I-PER\nlanded O\nhis O\nfirst O\ngroup O\none O\nvictory O\nin O\n25 O\nyears O\nas O\na O\ntrainer O\nwhen O\nhis O\ntop O\nsprinter O\nPivotal B-PER\n, O\na O\n100-30 O\nchance O\n, O\nwon O\nthe O\nNunthorpe B-MISC\nStakes I-MISC\non O\nThursday O\n. O\n\nThe O\nthree-year-old O\n, O\npartnered O\nby O\nveteran O\nGeorge B-PER\nDuffield I-PER\n, O\nsnatched O\na O\nshort O\nhead O\nverdict O\nin O\nthe O\nlast O\nstride O\nto O\ndeny O\nEveningperformance B-PER\n( O\n16-1 O\n) O\n, O\ntrained O\nby O\nHenry B-PER\nCandy I-PER\nand O\nridden O\nby O\nChris B-PER\nRutter I-PER\n. O\n\nHever B-PER\nGolf I-PER\nRose I-PER\n( O\n11-4 O\n) O\n, O\nlast O\nyear O\n's O\nPrix B-MISC\nde I-MISC\nl I-MISC\n' I-MISC\nAbbaye I-MISC\nwinner O\nat O\nLongchamp B-LOC\n, O\nfinished O\nthird O\n, O\na O\nfurther O\none O\nand O\na O\nquarter O\nlengths O\naway O\nwith O\nthe O\n7-4 O\nfavourite O\nMind B-PER\nGames I-PER\nin O\nfourth O\n. O\n\nPivotal B-PER\n, O\na O\nRoyal B-PER\nAscot I-PER\nwinner O\nin O\nJune O\n, O\nmay O\nnow O\nbe O\naimed O\nat O\nthis O\nseason O\n's O\nAbbaye B-MISC\n, O\nEurope B-LOC\n's O\ntop O\nsprint O\nrace O\n. O\n\nPrescott B-PER\n, O\nreluctant O\nto O\ngo O\ninto O\nthe O\nwinner O\n's O\nenclosure O\nuntil O\nthe O\nresult O\nof O\nthe O\nphoto-finish O\nwas O\nannounced O\n, O\nsaid O\n: O\n\" O\nTwenty-five O\nyears O\nand O\nI O\nhave O\nnever O\nbeen O\nthere O\nso O\nI O\nthought O\nI O\nhad O\nbetter O\nwait O\na O\nbit O\nlonger O\n. O\n\" O\n\nHe O\nadded O\n: O\n\" O\nIt O\n's O\nvery O\nsad O\nto O\nbeat O\nHenry B-PER\nCandy I-PER\nbecause O\nI O\nam O\ngodfather O\nto O\nhis O\ndaughter O\n. O\n\" O\n\nLike O\nPrescott B-PER\n, O\nJack B-PER\nBerry I-PER\n, O\ntrainer O\nof O\nMind B-PER\nGames I-PER\n, O\nhad O\ngone O\ninto O\nThursday O\n's O\nrace O\nin O\nsearch O\nof O\na O\nfirst O\ngroup O\none O\nsuccess O\nafter O\nmany O\nyears O\naround O\nthe O\ntop O\nof O\nhis O\nprofession O\n. O\n\nBerry B-PER\nsaid O\n: O\n\" O\nI`m O\ndisappointed O\nbut O\nI O\ndo O\nn't O\nfeel O\nsuicidal O\n. O\n\nHe O\n( O\nMind B-PER\nGames I-PER\n) O\nwas O\ngoing O\nas O\nwell O\nas O\nany O\nof O\nthem O\none O\nand O\na O\nhalf O\nfurlongs O\n( O\n300 O\nmetres O\n) O\nout O\nbut O\nhe O\njust O\ndid O\nn't O\nquicken O\n. O\n\" O\n\n-DOCSTART- O\n\nHORSE O\nRACING O\n- O\nNUNTHORPE O\nSTAKES O\nRESULTS O\n. O\n\nYORK B-LOC\n, O\nEngland B-LOC\n1996-08-22 O\n\nResult O\nof O\nthe O\nNunthorpe B-MISC\nStakes I-MISC\n, O\na O\ngroup O\none O\nrace O\nfor O\ntwo-year-olds O\nand O\nupwards O\n, O\nrun O\nover O\nfive O\nfurlongs O\n( O\n1 O\nkm O\n) O\non O\nThursday O\n: O\n\n1. O\nPivotal B-PER\n100-30 O\n( O\nridden O\nby O\nGeorge B-PER\nDuffield I-PER\n) O\n\n2. O\nEveningperformance B-PER\n16-1 O\n( O\nChris B-PER\nRutter I-PER\n) O\n\n3. O\nHever B-PER\nGolf I-PER\nRose I-PER\n11-4 O\n( O\nJason B-PER\nWeaver I-PER\n) O\n\nEight O\nran O\n. O\n\nFavourite O\n: O\nMind B-PER\nGames I-PER\n( O\n7-4 O\n) O\nfinished O\n4th O\n\nDistances O\n: O\na O\nshort O\nhead O\n, O\n1-1/4 O\nlengths O\n. O\n\nWinner O\nowned O\nby O\nthe O\nCheveley B-ORG\nPark I-ORG\nStud I-ORG\nand O\ntrained O\nby O\nSir O\n\nMark B-PER\nPrescott I-PER\nat O\nNewmarket B-LOC\n. O\n\nValue O\nto O\nwinner O\n: O\n72,464 O\npounds O\nsterling O\n( O\n$ O\n112,200 O\n) O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nTOSHIBA B-MISC\nCLASSIC I-MISC\n. O\n\nCARLSBAD B-LOC\n, O\nCalifornia B-LOC\n1996-08-21 O\n\nResults O\nfrom O\nthe O\n\n$ O\n450,000 O\nToshiba B-MISC\nClassic I-MISC\ntennis O\ntournament O\non O\nWednesday O\n\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nSecond O\nround O\n\n1 O\n- O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nNaoko B-PER\nKijimuta I-PER\n( O\nJapan B-LOC\n) O\n\n1-6 O\n6-4 O\n6-3 O\n\n4 O\n- O\nKimiko B-PER\nDate I-PER\n( O\nJapan B-LOC\n) O\nbeat O\nYone B-PER\nKamio I-PER\n( O\nJapan B-LOC\n) O\n6-2 O\n7-5 O\n\nSandrine B-PER\nTestud I-PER\n( O\nFrance B-LOC\n) O\nbeat O\n7 O\n- O\nAi B-PER\nSugiyama I-PER\n( O\nJapan B-LOC\n) O\n6-3 O\n4-6 O\n\n6-4 O\n\n8 O\n- O\nNathalie B-PER\nTauziat I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nShi-Ting B-PER\nWang I-PER\n( O\nTaiwan B-LOC\n) O\n6-4 O\n\n6-2 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nHAMLET B-MISC\nCUP I-MISC\n. O\n\nCOMMACK B-LOC\n, O\nNew B-LOC\nYork I-LOC\n1996-08-21 O\n\nResults O\nfrom O\nthe O\n\nWaldbaum B-MISC\nHamlet I-MISC\nCup I-MISC\ntennis O\ntournament O\non O\nWednesday O\n( O\nprefix O\n\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nSecond O\nround O\n\n1 O\n- O\nMichael B-PER\nChang I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nSergi B-PER\nBruguera I-PER\n( O\nSpain B-LOC\n) O\n6-3 O\n6-2 O\n\nMichael B-PER\nJoyce I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\n3 O\n- O\nRichey B-PER\nReneberg I-PER\n( O\nU.S. B-LOC\n) O\n3-6 O\n6-4 O\n\n6-3 O\n\nMartin B-PER\nDamm I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\n6 O\n- O\nYounes B-PER\nEl I-PER\nAynaoui I-PER\n\n( O\nMorocco B-LOC\n) O\n5-7 O\n6-3 O\n3-0 O\nretired O\n\nKarol B-PER\nKucera I-PER\n( O\nSlovakia B-LOC\n) O\nbeat O\nHicham B-PER\nArazi I-PER\n( O\nMorocco B-LOC\n) O\n7-6 O\n( O\n7-4 O\n) O\n\n7-5 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDALGLISH B-PER\nSAD O\nOVER O\nBLACKBURN B-ORG\nPARTING O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nKenny B-PER\nDalglish I-PER\nspoke O\non O\nThursday O\nof O\nhis O\nsadness O\nat O\nleaving O\nBlackburn B-ORG\n, O\nthe O\nclub O\nhe O\nled O\nto O\nthe O\nEnglish B-MISC\npremier O\nleague O\ntitle O\nin O\n1994-95 O\n. O\n\nBlackburn B-ORG\nannounced O\non O\nWednesday O\nthey O\nand O\nDalglish B-PER\nhad O\nparted O\nby O\nmutual O\nconsent O\n. O\n\nBut O\nthe O\nex-manager O\nconfessed O\non O\nThursday O\nto O\nbeing O\n\" O\nsad O\n\" O\nat O\nleaving O\nafter O\ntaking O\nBlackburn B-ORG\nfrom O\nthe O\nsecond O\ndivision O\nto O\nthe O\npremier O\nleague O\ntitle O\ninside O\nthree O\nand O\na O\nhalf O\nyears O\n. O\n\nIn O\na O\ntelephone O\ncall O\nto O\na O\nlocal O\nnewspaper O\nfrom O\nhis O\nholiday O\nhome O\nin O\nSpain B-LOC\n, O\nDalglish B-PER\nsaid O\n: O\n\" O\nWe O\ncame O\nto O\nthe O\nsame O\nopinion O\n, O\nalbeit O\nthe O\nclub O\ncame O\nto O\nit O\na O\nlittle O\nbit O\nearlier O\nthan O\nme O\n. O\n\" O\n\nHe O\nadded O\n: O\n\" O\nIf O\nno O\none O\nasked O\n, O\nI O\nnever O\nopened O\nmy O\nmouth O\n. O\n\nI O\nhave O\nstayed O\nout O\nof O\nthe O\nway O\nand O\nlet O\nthem O\nget O\non O\nwith O\nthe O\njob O\n. O\n\nThe O\nclub O\nthought O\nit O\n( O\nthe O\njob O\n) O\nhad O\nrun O\nits O\ncourse O\nand O\nI O\ncame O\nto O\nthe O\nsame O\nconclusion O\n. O\n\" O\n\nDalglish B-PER\nhad O\nbeen O\nwith O\nBlackburn B-ORG\nfor O\nnearly O\nfive O\nyears O\n, O\nfirst O\nas O\nmanager O\nand O\nthen O\n, O\nfor O\nthe O\npast O\n15 O\nmonths O\n, O\nas O\ndirector O\nof O\nfootball O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLISH B-MISC\nCOUNTY I-MISC\nCHAMPIONSHIP I-MISC\nSCORES O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nClose O\nof O\nplay O\nscores O\nin O\nfour-day O\n\nEnglish B-MISC\nCounty B-MISC\nChampionship I-MISC\ncricket O\nmatches O\non O\nThursday O\n: O\n\nSecond O\nday O\n\nAt O\nWeston-super-Mare B-LOC\n: O\nDurham B-ORG\n326 O\n( O\nD. B-PER\nCox I-PER\n95 O\nnot O\nout O\n, O\n\nS. B-PER\nCampbell I-PER\n69 O\n; O\nG. B-PER\nRose I-PER\n7-73 O\n) O\n. O\n\nSomerset B-ORG\n236-4 O\n( O\nM. B-PER\nLathwell I-PER\n85 O\n) O\n. O\n\nFirsy O\nday O\n\nAt O\nColchester B-LOC\n: O\nGloucestershire B-ORG\n280 O\n( O\nJ. B-PER\nRussell I-PER\n63 O\n, O\nA. B-PER\nSymonds I-PER\n\n52 O\n; O\nA. B-PER\nCowan I-PER\n5-68 O\n) O\n. O\n\nEssex B-ORG\n72-0 O\n. O\n\nAt O\nCardiff B-LOC\n: O\nKent B-ORG\n128-1 O\n( O\nM. B-PER\nWalker I-PER\n59 O\n, O\nD. B-PER\nFulton I-PER\n53 O\nnot O\nout O\n) O\nv O\n\nGlamorgan B-ORG\n. O\n\nAt O\nLeicester B-LOC\n: O\nLeicestershire B-ORG\n343-8 O\n( O\nP. B-PER\nSimmons I-PER\n108 O\n, O\nP. B-PER\nNixon I-PER\n\n67 O\nnot O\nout O\n) O\nv O\nHampshire B-ORG\n. O\n\nAt O\nNorthampton B-LOC\n: O\nSussex B-ORG\n368-7 O\n( O\nN. B-PER\nLenham I-PER\n145 O\n, O\nV. B-PER\nDrakes I-PER\n59 O\nnot O\n\nout O\n, O\nA. B-PER\nWells I-PER\n51 O\n) O\nv O\nNorthamptonshire B-ORG\n. O\n\nAt O\nTrent B-LOC\nBridge I-LOC\n: O\nNottinghamshire B-ORG\n392-6 O\n( O\nG. B-PER\nArcher I-PER\n143 O\nnot O\n\nout O\n, O\nM. B-PER\nDowman I-PER\n107 O\n) O\nv O\nSurrey B-ORG\n. O\n\nAt O\nWorcester B-LOC\n: O\nWarwickshire B-ORG\n255-9 O\n( O\nA. B-PER\nGiles I-PER\n57 O\nnot O\nout O\n, O\nW. B-PER\nKhan I-PER\n\n52 O\n) O\nv O\nWorcestershire B-ORG\n. O\n\nAt O\nHeadingley B-LOC\n: O\nYorkshire B-ORG\n305-5 O\n( O\nC. B-PER\nWhite I-PER\n66 O\nnot O\nout O\n, O\nM. B-PER\nMoxon I-PER\n\n66 O\n, O\nM. B-PER\nVaughan I-PER\n57 O\n) O\nv O\nLancashire B-ORG\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nV O\nPAKISTAN B-LOC\nFINAL O\nTEST O\nSCOREBOARD O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nScoreboard O\non O\nthe O\nfirst O\nday O\nof O\nthe O\n\nthird O\nand O\nfinal O\ntest O\nbetween O\nEngland B-LOC\nand O\nPakistan B-LOC\nat O\nThe B-LOC\nOval I-LOC\non O\n\nThursday O\n: O\n\nEngland B-LOC\nfirst O\ninnings O\n\nM. B-PER\nAtherton I-PER\nb O\nWaqar B-PER\nYounis I-PER\n31 O\n\nA. B-PER\nStewart I-PER\nb O\nMushtaq B-PER\nAhmed I-PER\n44 O\n\nN. B-PER\nHussain I-PER\nc O\nSaeed B-PER\nAnwar I-PER\nb O\nWaqar B-PER\nYounis I-PER\n12 O\n\nG. B-PER\nThorpe I-PER\nlbw O\nb O\nMohammad B-PER\nAkram I-PER\n54 O\n\nJ. B-PER\nCrawley I-PER\nnot O\nout O\n94 O\n\nN. B-PER\nKnight I-PER\nb O\nMushtaq B-PER\nAhmed I-PER\n17 O\n\nC. B-PER\nLewis I-PER\nb O\nWasim B-PER\nAkram I-PER\n5 O\n\nI. B-PER\nSalisbury I-PER\nnot O\nout O\n1 O\n\nExtras O\n( O\nlb-11 O\nw-1 O\nnb-8 O\n) O\n20 O\n\nTotal O\n( O\nfor O\nsix O\nwickets O\n) O\n278 O\n\nFall O\nof O\nwickets O\n: O\n1-64 O\n2-85 O\n3-116 O\n4-205 O\n5-248 O\n6-273 O\n\nTo O\nbat O\n: O\nR. B-PER\nCroft I-PER\n, O\nD. B-PER\nCork I-PER\n, O\nA. B-PER\nMullally I-PER\n\nBowling O\n( O\nto O\ndate O\n) O\n: O\nWasim B-PER\nAkram I-PER\n25-8-61-1 O\n, O\nWaqar B-PER\nYounis I-PER\n\n20-6-70-2 O\n, O\nMohammad B-PER\nAkram I-PER\n12-1-41-1 O\n, O\nMushtaq B-PER\nAhmed I-PER\n27-5-78-2 O\n, O\n\nAamir B-PER\nSohail I-PER\n6-1-17-0 O\n\nPakistan B-LOC\n: O\nAamir B-PER\nSohail I-PER\n, O\nSaeed B-PER\nAnwar I-PER\n, O\nIjaz B-PER\nAhmed I-PER\n, O\n\nInzamam-ul-Haq B-PER\n, O\nSalim B-PER\nMalik I-PER\n, O\nAsif B-PER\nMujtaba I-PER\n, O\nWasim B-PER\nAkram I-PER\n, O\nMoin B-PER\n\nKhan B-PER\n, O\nMushtaq B-PER\nAhmed I-PER\n, O\nWaqar B-PER\nYounis I-PER\n, O\nMohammad B-PER\nAkam I-PER\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFERGUSON B-PER\nBACK O\nIN O\nSCOTTISH B-MISC\nSQUAD O\nAFTER O\n20 O\nMONTHS O\n. O\n\nGLASGOW B-LOC\n1996-08-22 O\n\nEverton B-ORG\n's O\nDuncan B-PER\nFerguson I-PER\n, O\nwho O\nscored O\ntwice O\nagainst O\nManchester B-ORG\nUnited I-ORG\non O\nWednesday O\n, O\nwas O\npicked O\non O\nThursday O\nfor O\nthe O\nScottish B-MISC\nsquad O\nafter O\na O\n20-month O\nexile O\n. O\n\nGlasgow B-ORG\nRangers I-ORG\nstriker O\nAlly B-PER\nMcCoist I-PER\n, O\nanother O\nman O\nin O\nform O\nafter O\ntwo O\nhat-tricks O\nin O\nfour O\ndays O\n, O\nwas O\nalso O\nnamed O\nfor O\nthe O\nAugust O\n31 O\nWorld B-MISC\nCup I-MISC\nqualifier O\nagainst O\nAustria B-LOC\nin O\nVienna B-LOC\n. O\n\nFerguson B-PER\n, O\nwho O\nserved O\nsix O\nweeks O\nin O\njail O\nin O\nlate O\n1995 O\nfor O\nhead-butting O\nan O\nopponent O\n, O\nwon O\nthe O\nlast O\nof O\nhis O\nfive O\nScotland B-LOC\ncaps O\nin O\nDecember O\n1994 O\n. O\n\nScotland B-LOC\nmanager O\nCraig B-PER\nBrown I-PER\nsaid O\non O\nThursday O\n: O\n\" O\nI O\n've O\nwatched O\nDuncan B-PER\nFerguson I-PER\nin O\naction O\ntwice O\nrecently O\nand O\nhe O\n's O\nbang O\nin O\nform O\n. O\n\nAlly B-PER\nMcCoist I-PER\nis O\nalso O\nin O\ngreat O\nscoring O\nform O\nat O\nthe O\nmoment O\n. O\n\" O\n\nCeltic B-ORG\n's O\nJackie B-PER\nMcNamara I-PER\n, O\nwho O\ndid O\nwell O\nwith O\nlast O\nseason O\n's O\nsuccessful O\nunder-21 O\nteam O\n, O\nearns O\na O\ncall-up O\nto O\nthe O\nsenior O\nsquad O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\n100-2 O\nAT O\nLUNCH O\nON O\nFIRST O\nDAY O\nOF O\nTHIRD O\nTEST O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nEngland B-LOC\nwere O\n100 O\nfor O\ntwo O\nat O\nlunch O\non O\nthe O\nfirst O\nday O\nof O\nthe O\nthird O\nand O\nfinal O\ntest O\nagainst O\nPakistan B-LOC\nat O\nThe B-LOC\nOval I-LOC\non O\nThursday O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nKEANE B-PER\nSIGNS O\nFOUR-YEAR O\nCONTRACT O\nWITH O\nMANCHESTER B-LOC\nUNITED I-LOC\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nIreland B-LOC\nmidfielder O\nRoy B-PER\nKeane I-PER\nhas O\nsigned O\na O\nnew O\nfour-year O\ncontract O\nwith O\nEnglish B-MISC\nleague O\nand O\nF.A. B-MISC\nCup I-MISC\nchampions O\nManchester B-ORG\nUnited I-ORG\n. O\n\n\" O\nRoy B-PER\nagreed O\na O\nnew O\ndeal O\nbefore O\nlast O\nnight O\n's O\ngame O\nagainst O\nEverton B-ORG\nand O\nwe O\nare O\ndelighted O\n, O\n\" O\nsaid O\nUnited B-ORG\nmanager O\nAlex B-PER\nFerguson I-PER\non O\nThursday O\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nCANADIAN B-MISC\nOPEN I-MISC\n. O\n\nTORONTO B-LOC\n1996-08-21 O\n\nResults O\nfrom O\nthe O\nCanadian B-MISC\nOpen I-MISC\n\ntennis O\ntournament O\non O\nWednesday O\n( O\nprefix O\nnumber O\ndenotes O\n\nseeding O\n) O\n: O\n\nSecond O\nround O\n\nDaniel B-PER\nNestor I-PER\n( O\nCanada B-LOC\n) O\nbeat O\n1 O\n- O\nThomas B-PER\nMuster I-PER\n( O\nAustria B-LOC\n) O\n6-3 O\n7-5 O\n\nMikael B-PER\nTillstrom I-PER\n( O\nSweden B-LOC\n) O\nbeat O\n2 O\n- O\nGoran B-PER\nIvanisevic I-PER\n( O\nCroatia B-LOC\n) O\n\n6-7 O\n( O\n3-7 O\n) O\n6-4 O\n6-4 O\n\n3 O\n- O\nWayne B-PER\nFerreira I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\nJiri B-PER\nNovak I-PER\n( O\nCzech B-LOC\n\nRepublic B-LOC\n) O\n7-5 O\n6-3 O\n\n4 O\n- O\nMarcelo B-PER\nRios I-PER\n( O\nChile B-LOC\n) O\nbeat O\nKenneth B-PER\nCarlsen I-PER\n( O\nDenmark B-LOC\n) O\n6-3 O\n6-2 O\n\n6 O\n- O\nMaliVai B-PER\nWashington I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAlex B-PER\nCorretja I-PER\n( O\nSpain B-LOC\n) O\n6-4 O\n\n6-2 O\n\n7 O\n- O\nTodd B-PER\nMartin I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nRenzo B-PER\nFurlan I-PER\n( O\nItaly B-LOC\n) O\n7-6 O\n( O\n7-3 O\n) O\n6-3 O\n\nMark B-PER\nPhilippoussis I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\n8 O\n- O\nMarc B-PER\nRosset I-PER\n\n( O\nSwitzerland B-LOC\n) O\n6-3 O\n3-6 O\n7-6 O\n( O\n8-6 O\n) O\n\n9 O\n- O\nCedric B-PER\nPioline I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nGregory B-PER\nCarraz I-PER\n( O\nFrance B-LOC\n) O\n7-6 O\n\n( O\n7-1 O\n) O\n6-4 O\n\nPatrick B-PER\nRafter I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\n11 O\n- O\nAlberto B-PER\nBerasategui I-PER\n\n( O\nSpain B-LOC\n) O\n6-1 O\n6-2 O\n\nPetr B-PER\nKorda I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\n12 O\n- O\nFrancisco B-PER\nClavet I-PER\n( O\nSpain B-LOC\n) O\n\n6-3 O\n6-4 O\n\nDaniel B-PER\nVacek I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\n13 O\n- O\nJason B-PER\nStoltenberg I-PER\n\n( O\nAustralia B-LOC\n) O\n5-7 O\n7-6 O\n( O\n7-1 O\n) O\n7-6 O\n( O\n13-11 O\n) O\n\nTodd B-PER\nWoodbridge I-PER\n( O\nAustralia B-LOC\nbeat O\nSebastien B-PER\nLareau I-PER\n( O\nCanada B-LOC\n) O\n6-3 O\n\n1-6 O\n6-3 O\n\nAlex B-PER\nO'Brien I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nByron B-PER\nBlack I-PER\n( O\nZimbabwe B-LOC\n) O\n7-6 O\n( O\n7-2 O\n) O\n6-2 O\n\nBohdan B-PER\nUlihrach I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nAndrea B-PER\nGaudenzi I-PER\n( O\nItaly B-LOC\n) O\n\n6-3 O\n4-6 O\n6-1 O\n\nTim B-PER\nHenman I-PER\n( O\nBritain B-LOC\n) O\nbeat O\nChris B-PER\nWoodruff I-PER\n( O\nU.S. B-LOC\n) O\n, O\nwalkover O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nMILLNS B-PER\nSIGNS O\nFOR O\nBOLAND B-ORG\n. O\n\nCAPE B-LOC\nTOWN I-LOC\n1996-08-22 O\n\nSouth B-MISC\nAfrican I-MISC\nprovincial O\nside O\nBoland B-ORG\nsaid O\non O\nThursday O\nthey O\nhad O\nsigned O\nLeicestershire B-ORG\nfast O\nbowler O\nDavid B-PER\nMillns I-PER\non O\na O\none O\nyear O\ncontract O\n. O\n\nMillns B-MISC\n, O\nwho O\ntoured O\nAustralia B-LOC\nwith O\nEngland B-LOC\nA O\nin O\n1992/93 O\n, O\nreplaces O\nformer O\nEngland B-LOC\nall-rounder O\nPhillip B-PER\nDeFreitas I-PER\nas O\nBoland B-ORG\n's O\noverseas O\nprofessional O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nEUROPEAN B-MISC\nCUP I-MISC\nWINNERS I-MISC\n' I-MISC\nCUP I-MISC\nRESULTS O\n. O\n\nTIRANA B-LOC\n1996-08-22 O\n\nResults O\nof O\nEuropean B-MISC\nCup I-MISC\nWinners I-MISC\n' I-MISC\n\nCup B-MISC\nqualifying O\nround O\n, O\nsecond O\nleg O\nsoccer O\nmatches O\non O\nThursday O\n: O\n\nIn O\nTirana B-LOC\n: O\nFlamurtari B-ORG\nVlore I-ORG\n( O\nAlbania B-LOC\n) O\n0 O\nChemlon B-ORG\nHumenne I-ORG\n\n( O\nSlovakia B-LOC\n) O\n2 O\n( O\nhalftime O\n0-0 O\n) O\n\nScorers O\n: O\nLubarskij B-PER\n( O\n50th O\nminute O\n) O\n, O\nValkucak B-PER\n( O\n54th O\n) O\n\nAttendance O\n: O\n5,000 O\n\nChemlon B-ORG\nHumenne I-ORG\nwin O\n3-0 O\non O\naggregate O\n\nIn O\nBistrita B-LOC\n: O\nGloria B-ORG\nBistrita I-ORG\n( O\nRomania B-LOC\n) O\n2 O\nValletta B-LOC\n( O\nMalta B-LOC\n) O\n1 O\n\n( O\n1-1 O\n) O\n\nScorers O\n: O\n\nGloria B-ORG\nBistrita I-ORG\n- O\nIlie B-PER\nLazar I-PER\n( O\n32nd O\n) O\n, O\nEugen B-PER\nVoica I-PER\n( O\n84th O\n) O\n\nValletta B-LOC\n- O\nGilbert B-PER\nAgius I-PER\n( O\n24th O\n) O\n\nAttendance O\n: O\n8,000 O\n\nGloria B-ORG\nBistrita I-ORG\nwin O\n4-2 O\non O\naggregate O\n. O\n\nIn O\nChorzow B-LOC\n: O\nRuch B-ORG\nChorzow I-ORG\n( O\nPoland B-LOC\n) O\n5 O\nLlansantffraid B-ORG\n( O\nWales B-LOC\n) O\n0 O\n\n( O\n1-0 O\n) O\n\nScorers O\n: O\nArkadiusz B-PER\nBak I-PER\n( O\n1st O\nand O\n55th O\n) O\n, O\nArwel B-PER\nJones I-PER\n( O\n47th O\n, O\n\nown O\ngoal O\n) O\n, O\nMiroslav B-PER\nBak I-PER\n( O\n62nd O\nand O\n63rd O\n) O\n\nAttendance O\n: O\n6,500 O\n\nRuch B-ORG\nChorzow I-ORG\nwin O\n6-1 O\non O\naggregate O\n\nIn O\nLarnaca B-LOC\n: O\nAEK B-ORG\nLarnaca I-ORG\n( O\nCyprus B-LOC\n) O\n5 O\nKotaik B-ORG\nAbovyan I-ORG\n( O\nArmenia B-LOC\n) O\n\n0 O\n( O\n2-0 O\n) O\n\nScorers O\n: O\nZoran B-PER\nKundic I-PER\n( O\n28th O\n) O\n, O\nKlimis B-PER\nAlexandrou I-PER\n( O\n41st O\n) O\n, O\n\nMilenko B-PER\nKovasevic I-PER\n( O\n60th O\n, O\npenalty O\n) O\n, O\nGoran B-PER\nKoprinovic I-PER\n( O\n82nd O\n) O\n, O\n\nPavlos B-PER\nMarkou I-PER\n( O\n84th O\n) O\n\nAttendance O\n: O\n5,000 O\n\nAEK B-ORG\nLarnaca I-ORG\nwin O\n5-1 O\non O\naggregate O\n\nIn O\nSiauliai B-LOC\n: O\nKareda B-ORG\nSiauliai I-ORG\n( O\nLithuania B-LOC\n) O\n0 O\nSion B-ORG\n\n( O\nSwitzerland B-LOC\n) O\n0 O\n\nAttendance O\n: O\n5,000 O\n\nSion B-ORG\nwin O\n4-2 O\non O\nagrregate O\n. O\n\nIn O\nVinnytsya B-LOC\n: O\n\nNyva B-ORG\nVinnytsya I-ORG\n( O\nUkraine B-LOC\n) O\n1 O\nTallinna B-ORG\nSadam I-ORG\n( O\nEstonia B-LOC\n) O\n0 O\n( O\n0-0 O\n) O\n\nAttendance O\n: O\n3,000 O\n\nAggregate O\nscore O\n2-2 O\n. O\n\nNyva B-ORG\nqualified O\non O\naway O\ngoals O\nrule O\n. O\n\nIn O\nBergen B-LOC\n: O\nBrann B-ORG\n( O\nNorway B-LOC\n) O\n2 O\nShelbourne B-ORG\n( O\nIreland B-LOC\n) O\n1 O\n( O\n1-1 O\n) O\n\nScorers O\n: O\n\nBrann B-ORG\n- O\nMons B-PER\nIvar I-PER\nMjelde I-PER\n( O\n10th O\n) O\n, O\nJan B-PER\nOve I-PER\nPedersen I-PER\n( O\n72nd O\n) O\n\nShelbourne B-ORG\n- O\nMark B-PER\nRutherford I-PER\n( O\n5th O\n) O\n\nAttendance O\n: O\n2,189 O\n\nBrann B-ORG\nwin O\n5-2 O\non O\naggregate O\n\nIn O\nSofia B-LOC\n: O\nLevski B-ORG\nSofia I-ORG\n( O\nBulgaria B-LOC\n) O\n1 O\nOlimpija B-ORG\n( O\nSlovenia B-LOC\n) O\n0 O\n\n( O\n0-0 O\n) O\n\nScorer O\n: O\nIlian B-PER\nSimeonov I-PER\n( O\n58th O\n) O\n\nAttendance O\n: O\n25,000 O\n\nAggregate O\n1-1 O\n. O\n\nOlimpija B-ORG\nwon O\n4-3 O\non O\npenalties O\n. O\n\nIn O\nVaduz B-LOC\n: O\nVaduz B-LOC\n( O\nLiechtenstein B-LOC\n) O\n1 O\nRAF B-ORG\nRiga I-ORG\n( O\nLatvia B-LOC\n) O\n1 O\n( O\n0-0 O\n) O\n\nScorers O\n: O\n\nVaduz B-LOC\n- O\nDaniele B-PER\nPolverino I-PER\n( O\n90th O\n) O\n\nRAF B-ORG\nRiga I-ORG\n- O\nAgrins B-PER\nZarins I-PER\n( O\n47th O\n) O\n\nAggregate O\n2-2 O\n. O\n\nVaduz B-LOC\nwon O\n4-2 O\non O\npenalties O\n. O\n\nIn O\nLuxembourg B-LOC\n: O\nUS B-ORG\nLuxembourg I-ORG\n( O\nLuxembourg B-LOC\n) O\n0 O\nVarteks B-ORG\nVarazdin I-ORG\n\n( O\nCroatia B-LOC\n) O\n3 O\n( O\n0-0 O\n) O\n\nScorers O\n: O\nDrazen B-PER\nBeser I-PER\n( O\n63rd O\n) O\n, O\nMiljenko B-PER\nMumler I-PER\n( O\npenalty O\n, O\n\n78th O\n) O\n, O\nJamir B-PER\nCvetko I-PER\n( O\n87th O\n) O\n\nAttendance O\n: O\n800 O\n\nVarteks B-ORG\nVarazdin I-ORG\nwin O\n5-1 O\non O\naggregate O\n. O\n\nIn O\nTorshavn B-LOC\n: O\nHavnar B-ORG\nBoltfelag I-ORG\n( O\nFaroe B-LOC\nIslands I-LOC\n) O\n0 O\nDynamo B-ORG\n\nBatumi B-ORG\n( O\nGeorgia B-LOC\n) O\n3 O\n( O\n0-2 O\n) O\n\nDynamo B-ORG\nBatumi I-ORG\nwin O\n9-0 O\non O\naggregate O\n. O\n\nIn O\nPrague B-LOC\n: O\nSparta B-ORG\nPrague I-ORG\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n8 O\nGlentoran B-ORG\n\n( O\nNorthern B-LOC\nIreland I-LOC\n) O\n0 O\n( O\n4-0 O\n) O\n\nScorers O\n: O\nPetr B-PER\nGunda I-PER\n( O\n1st O\nand O\n26th O\n) O\n, O\nLumir B-PER\nMistr I-PER\n( O\n19th O\n) O\n, O\n\nHorst B-PER\nSiegl I-PER\n( O\n24th O\n, O\n48th O\n, O\n80th O\n) O\n, O\nZdenek B-PER\nSvoboda I-PER\n( O\n76th O\n) O\n, O\nPetr B-PER\n\nGabriel B-PER\n( O\n86th O\n) O\n\nSparta B-ORG\nwin O\n10-1 O\non O\naggregate O\n. O\n\nIn O\nEdinburgh B-LOC\n: O\nHearts B-ORG\n( O\nScotland B-LOC\n) O\n1 O\nRed B-ORG\nStar I-ORG\nBelgrade I-ORG\n\n( O\nYugoslavia B-LOC\n) O\n1 O\n( O\n1-0 O\n) O\n\nScorers O\n: O\n\nHearts B-ORG\n- O\nDave B-PER\nMcPherson I-PER\n( O\n44th O\n) O\n\nRed B-ORG\nStar I-ORG\n- O\nVinko B-MISC\nMarinovic I-MISC\n( O\n59th O\n) O\n\nAttendance O\n: O\n15,062 O\n\nAggregate O\n1-1 O\n. O\n\nRed B-ORG\nStar I-ORG\nwin O\non O\naway O\ngoals O\nrule O\n. O\n\nIn O\nRishon-Lezion B-LOC\n: O\nHapoel B-ORG\nIroni I-ORG\n( O\nIsrael B-LOC\n) O\n3 O\nConstructorul B-ORG\n\nChisinau B-ORG\n( O\nMoldova B-LOC\n) O\n2 O\n( O\n2-1 O\n) O\n\nAggregate O\n3-3 O\n. O\n\nConstructorul B-ORG\nwin O\non O\naway O\ngoals O\nrule O\n. O\n\nIn O\nAnjalonkoski B-MISC\n: O\nMyPa-47 B-ORG\n( O\nFinland B-LOC\n) O\n1 O\nKarabach B-ORG\nAgdam I-ORG\n\n( O\nAzerbaijan B-LOC\n) O\n1 O\n( O\n0-0 O\n) O\n\nMypa-47 B-ORG\nwin O\n2-1 O\non O\naggregate O\n. O\n\nIn O\nSkopje B-LOC\n: O\nSloga B-ORG\nJugomagnat I-ORG\n( O\nMacedonia B-LOC\n) O\n0 O\nKispest B-ORG\nHonved I-ORG\n\n( O\nHungary B-LOC\n1 O\n( O\n0-0 O\n) O\n\nKispest B-ORG\nHonved I-ORG\nwin O\n2-0 O\non O\naggregate O\n. O\n\nAdd B-ORG\nHapoel I-ORG\nIroni I-ORG\nv O\nConstructorul B-ORG\nChisinau I-ORG\n\nScorers O\n: O\n\nRishon B-ORG\n- O\nMoshe B-PER\nSabag I-PER\n( O\n10th O\nminute O\n) O\n, O\nNissan B-PER\nKapeta I-PER\n( O\n26th O\n) O\n, O\n\nTomas B-PER\nCibola I-PER\n( O\n58th O\n) O\n. O\n\nConstructorol B-ORG\n- O\nSergei B-PER\nRogachev I-PER\n( O\n42nd O\n) O\n, O\nGennadi B-PER\nSkidan I-PER\n\n( O\n87th O\n) O\n. O\n\nAttendance O\n: O\n1,500 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGOTHENBURG B-LOC\nPUT O\nFERENCVAROS B-ORG\nOUT O\nOF O\nEURO B-MISC\nCUP I-MISC\n. O\n\nBUDAPEST B-LOC\n1996-08-21 O\n\nIFK B-ORG\nGothenburg I-ORG\nof O\nSweden B-LOC\ndrew O\n1-1 O\n( O\n1-0 O\n) O\nwith O\nFerencvaros B-ORG\nof O\nHungary B-LOC\nin O\nthe O\nsecond O\nleg O\nof O\ntheir O\nEuropean B-MISC\nChampions I-MISC\nCup I-MISC\npreliminary O\nround O\ntie O\nplayed O\non O\nWednesday O\n. O\n\nGothenburg B-LOC\ngo O\nthrough O\n4-1 O\non O\naggregate O\n. O\n\nScorers O\n: O\n\nFerencvaros B-ORG\n: O\n\nFerenc B-PER\nHorvath I-PER\n( O\n15th O\n) O\n\nIFK B-ORG\nGothenburg I-ORG\n: O\n\nAndreas B-PER\nAndersson I-PER\n( O\n87th O\n) O\n\nAttendance O\n: O\n9,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBRAZILIAN B-MISC\nCHAMPIONSHIP O\nRESULTS O\n. O\n\nRIO B-LOC\nDE I-LOC\nJANEIRO I-LOC\n1996-08-22 O\n\nResults O\nof O\nmidweek O\n\nmatches O\nin O\nthe O\nBrazilian B-MISC\nsoccer O\nchampionship O\n. O\n\nBahia B-ORG\n2 O\nAtletico B-ORG\nParanaense I-ORG\n0 O\n\nCorinthians B-ORG\n1 O\nGuarani B-ORG\n0 O\n\nCoritiba B-ORG\n1 O\nAtletico B-ORG\nMineiro I-ORG\n0 O\n\nCruzeiro B-ORG\n2 O\nVitoria B-ORG\n1 O\n\nFlamengo B-ORG\n0 O\nJuventude B-ORG\n1 O\n\nGoias B-ORG\n3 O\nSport B-ORG\nRecife I-ORG\n1 O\n\nGremio B-ORG\n6 O\nBragantino B-ORG\n1 O\n\nPalmeiras B-ORG\n3 O\nVasco B-ORG\nda I-ORG\nGama I-ORG\n1 O\n\nPortuguesa B-ORG\n2 O\nParana B-ORG\n0 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nNEWCOMBE B-PER\nPONDERS O\nHIS O\nDAVIS B-MISC\nCUP I-MISC\nFUTURE O\n. O\n\nSYDNEY B-LOC\n1996-08-22 O\n\nAustralian B-MISC\nDavis B-MISC\nCup I-MISC\ncaptain O\nJohn B-PER\nNewcombe I-PER\non O\nThursday O\nsignalled O\nhis O\npossible O\nresignation O\nif O\nhis O\nteam O\nloses O\nan O\naway O\ntie O\nagainst O\nCroatia B-LOC\nnext O\nmonth O\n. O\n\nThe O\nformer O\nWimbledon B-MISC\nchampion O\nsaid O\nthe O\nimmediate O\nfuture O\nof O\nAustralia B-LOC\n's O\nDavis B-MISC\nCup I-MISC\ncoach O\nTony B-PER\nRoche I-PER\ncould O\nalso O\nbe O\ndetermined O\nby O\nevents O\nin O\nSplit B-LOC\n. O\n\n\" O\nIf O\nwe O\nlose O\nthis O\none O\n, O\nTony B-PER\nand O\nI O\nwill O\nhave O\nto O\nhave O\na O\ngood O\nlook O\nat O\ngiving O\nsomeone O\nelse O\na O\ngo O\n, O\n\" O\nNewcombe B-PER\nwas O\nquoted O\nas O\nsaying O\nin O\nSydney B-LOC\n's O\nDaily B-ORG\nTelegraph I-ORG\nnewspaper O\n. O\n\nAustralia B-LOC\nface O\nCroatia B-LOC\nin O\nthe O\nworld O\ngroup O\nqualifying O\ntie O\non O\nclay O\nfrom O\nSeptember O\n20-22 O\n. O\n\nUnder O\nNewcombe B-PER\n's O\nleadership O\n, O\nAustralia B-LOC\nwere O\nrelegated O\nfrom O\nthe O\nelite O\nworld O\ngroup O\nlast O\nyear O\n, O\nthe O\nfirst O\ntime O\nthe O\n26-time O\nDavis B-MISC\nCup I-MISC\nwinners O\nhad O\nslipped O\nfrom O\nthe O\ntop O\nrank O\n. O\n\nSince O\ntaking O\nover O\nas O\ncaptain O\nfrom O\nNeale B-PER\nFraser I-PER\nin O\n1994 O\n, O\nNewcombe B-PER\n's O\nrecord O\nin O\ntandem O\nwith O\nRoche B-PER\n, O\nhis O\nformer O\ndoubles O\npartner O\n, O\nhas O\nbeen O\nthree O\nwins O\nand O\nthree O\nlosses O\n. O\n\nNewcombe B-PER\nhas O\nselected O\nWimbledon B-MISC\nsemifinalist O\nJason B-PER\nStoltenberg I-PER\n, O\nPatrick B-PER\nRafter I-PER\n, O\nMark B-PER\nPhilippoussis I-PER\n, O\nand O\nOlympic B-MISC\ndoubles O\nchampions O\nTodd B-PER\nWoodbridge I-PER\nand O\nMark B-PER\nWoodforde I-PER\nto O\nface O\nthe O\nCroatians B-MISC\n. O\n\nThe O\nhome O\nside O\nboasts O\nworld O\nnumber O\nsix O\nGoran B-PER\nIvanisevic I-PER\n, O\nand O\nNewcombe B-PER\nconceded O\nhis O\nplayers O\nwould O\nbe O\nhard-pressed O\nto O\nbeat O\nthe O\nCroatian B-MISC\nnumber O\none O\n. O\n\n\" O\nWe O\nare O\nready O\nto O\nfight O\nto O\nour O\nlast O\nbreath O\n-- O\nAustralia B-LOC\nmust O\nplay O\nat O\nits O\nabsolute O\nbest O\nto O\nwin O\n, O\n\" O\nsaid O\nNewcombe B-PER\n, O\nwho O\ndescribed O\nthe O\ntie O\nas O\nthe O\ntoughest O\nhe O\nhas O\nfaced O\nas O\ncaptain O\n. O\n\nAustralia B-LOC\nlast O\nwon O\nthe O\nDavis B-MISC\nCup I-MISC\nin O\n1986 O\n, O\nbut O\nthey O\nwere O\nbeaten O\nfinalists O\nagainst O\nGermany B-LOC\nthree O\nyears O\nago O\nunder O\nFraser B-PER\n's O\nguidance O\n. O\n\n-DOCSTART- O\n\nBADMINTON O\n- O\nMALAYSIAN B-MISC\nOPEN I-MISC\nRESULTS O\n. O\n\nKUALA B-LOC\nLUMPUR I-LOC\n1996-08-22 O\n\nResults O\nin O\nthe O\nMalaysian B-MISC\n\nOpen B-MISC\nbadminton O\ntournament O\non O\nThursday O\n( O\nprefix O\nnumber O\ndenotes O\n\nseeding O\n) O\n: O\n\nMen O\n's O\nsingles O\n, O\nthird O\nround O\n\n9/16 O\n- O\nLuo B-PER\nYigang I-PER\n( O\nChina B-LOC\n) O\nbeat O\nHwang B-PER\nSun-ho B-MISC\n( O\nSouth B-LOC\nKorea I-LOC\n) O\n15-3 O\n\n15-7 O\n\nJason B-PER\nWong I-PER\n( O\nMalaysia B-LOC\n) O\nbeat O\nAbdul B-PER\nSamad I-PER\nIsmail I-PER\n( O\nMalaysia B-LOC\n) O\n16-18 O\n\n15-2 O\n17-14 O\n\nP. B-PER\nKantharoopan I-PER\n( O\nMalaysia B-LOC\n) O\nbeat O\n3/4 O\n- O\nJeroen B-PER\nVan I-PER\nDijk I-PER\n\n( O\nNetherlands B-LOC\n) O\n15-11 O\n18-14 O\n\nWijaya B-PER\nIndra I-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\n5/8 O\n- O\nPang B-PER\nChen I-PER\n( O\nMalaysia B-LOC\n) O\n15-6 O\n\n6-15 O\n15-7 O\n\n3/4 O\n- O\nHu B-PER\nZhilan I-PER\n( O\nChina B-LOC\n) O\nbeat O\nNunung B-PER\nSubandoro I-PER\n( O\nIndonesia B-LOC\n) O\n5-15 O\n\n18-15 O\n15-6 O\n\n9/16 O\n- O\nHermawan B-PER\nSusanto I-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\n1 O\n- O\nFung B-PER\nPermadi I-PER\n( O\nTaiwan B-LOC\n) O\n\n15-8 O\n15-12 O\n\nWomen O\n's O\nsingles O\n2nd O\nround O\n\n1 O\n- O\nWang B-PER\nChen I-PER\n( O\nChina B-LOC\n) O\nbeat O\nCindana B-PER\n( O\nIndonesia B-LOC\n) O\n11-3 O\n1ama B-PER\n( O\nJapan B-LOC\n) O\nbeat O\nMargit B-PER\nBorg I-PER\n( O\nSweden B-LOC\n) O\n11-6 O\n11-6 O\n\nSun B-PER\nJian I-PER\n( O\nChina B-LOC\n) O\nbeat O\nMarina B-PER\nAndrievskaqya I-PER\n( O\nSweden B-LOC\n) O\n11-8 O\n11-2 O\n\n5/8 O\n- O\nMeluawati B-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\nChan B-PER\nChia I-PER\nFong I-PER\n( O\nMalaysia B-LOC\n) O\n11-6 O\n\n11-1 O\n\nGong B-PER\nZhichao I-PER\n( O\nChina B-LOC\n) O\nbeat O\nLiu B-PER\nLufung I-PER\n( O\nChina B-LOC\n) O\n6-11 O\n11-7 O\n11-3 O\n\nZeng B-PER\nYaqiong I-PER\n( O\nChina B-LOC\n) O\nbeat O\nLi B-PER\nFeng I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n11-9 O\n11-6 O\n\n5/8 O\n- O\nChristine B-PER\nMagnusson I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nIshwari B-PER\nBoopathy I-PER\n\n( O\nMalaysia B-LOC\n) O\n11-1 O\n10-12 O\n11-4 O\n\n2 O\n- O\nZhang B-PER\nNing I-PER\n( O\nChina B-LOC\n) O\nbeat O\nOlivia B-PER\n( O\nIndonesia B-LOC\n) O\n11-8 O\n11-6 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nREVISED O\nMEN O\n'S O\nDRAW O\nFOR O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-22 O\n\nRevised O\nsingles O\ndraw O\nfor O\nthe O\n\nU.S. B-MISC\nOpen I-MISC\ntennis O\nchampionships O\nbeginning O\nMonday O\nat O\nthe O\nU.S B-LOC\n. O\n\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\n( O\nprefix O\ndenotes O\nseeding O\n) O\n: O\n\nMen O\n's O\nDraw O\n\n1 O\n- O\nPete B-PER\nSampras I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nAdrian B-PER\nVoinea I-PER\n( O\nRomania B-LOC\n) O\n\nJiri B-PER\nNovak I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nvs. O\nqualifier O\n\nMagnus B-PER\nLarsson I-PER\n( O\nSweden B-LOC\n) O\nvs. O\nAlexander B-PER\nVolkov I-PER\n( O\nRussia B-LOC\n) O\n\nMikael B-PER\nTillstrom I-PER\n( O\nSweden B-LOC\n) O\nvs O\nqualifier O\n\nQualifier O\nvs. O\nAndrei B-PER\nOlhovskiy I-PER\n( O\nRussia B-LOC\n) O\n\nMark B-PER\nWoodforde I-PER\n( O\nAustralia B-LOC\n) O\nvs. O\nMark B-PER\nPhilippoussis I-PER\n( O\nAustralia B-LOC\n) O\n\nRoberto B-PER\nCarretero I-PER\n( O\nSpain B-LOC\n) O\nvs. O\nJordi B-PER\nBurillo I-PER\n( O\nSpain B-LOC\n) O\n\nFrancisco B-PER\nClavet I-PER\n( O\nSpain B-LOC\n) O\nvs. O\n16 O\n- O\nCedric B-PER\nPioline I-PER\n( O\nFrance B-LOC\n) O\n\n------------------------ O\n\n9 O\n- O\nWayne B-PER\nFerreira I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nvs. O\nqualifier O\n\nKarol B-PER\nKucera I-PER\n( O\nSlovakia B-LOC\n) O\nvs. O\nJonas B-PER\nBjorkman I-PER\n( O\nSweden B-LOC\n) O\n\nQualifier O\nvs. O\nChristian B-PER\nRudd I-PER\n( O\nNorway B-LOC\n) O\n\nAlex B-PER\nCorretja I-PER\n( O\nSpain B-LOC\n) O\nvs. O\nByron B-PER\nBlack I-PER\n( O\nZimbabwe B-LOC\n) O\n\nDavid B-PER\nRikl I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nvs. O\nHicham B-PER\nArazi I-PER\n( O\nMorocco B-LOC\n) O\n\nSjeng B-PER\nSchalken I-PER\n( O\nNetherlands B-LOC\n) O\nvs. O\nGilbert B-PER\nSchaller I-PER\n( O\nAustria B-LOC\n) O\n\nGrant B-PER\nStafford I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nvs. O\nGuy B-PER\nForget I-PER\n( O\nFrance B-LOC\n) O\n\nFernando B-PER\nMeligeni I-PER\n( O\nBrazil B-LOC\n) O\nvs. O\n7 O\n- O\nYevgeny B-PER\nKafelnikov I-PER\n( O\nRussia B-LOC\n) O\n\n------------------------ O\n\n4 O\n- O\nGoran B-PER\nIvanisevic I-PER\n( O\nCroatia B-LOC\n) O\nvs. O\nAndrei B-PER\nChesnokov I-PER\n( O\nRussia B-LOC\n) O\n\nScott B-PER\nDraper I-PER\n( O\nAustralia B-LOC\n) O\nvs. O\nGalo B-PER\nBlanco I-PER\n( O\nSpain B-LOC\n) O\n\nRenzo B-PER\nFurlan I-PER\n( O\nItaly B-LOC\n) O\nvs. O\nThomas B-PER\nJohansson I-PER\n( O\nSweden B-LOC\n) O\n\nHendrik B-PER\nDreekman I-PER\n( O\nGermany B-LOC\n) O\nvs. O\nGreg B-PER\nRusedski I-PER\n( O\nBritain B-LOC\n) O\n\nAndrei B-PER\nMedvedev I-PER\n( O\nUkraine B-LOC\n) O\nvs. O\nJean-Philippe B-PER\nFleurian I-PER\n( O\nFrance B-LOC\n) O\n\nJan B-PER\nKroslak I-PER\n( O\nSlovakia B-LOC\n) O\nvs. O\nChris B-PER\nWoodruff I-PER\n( O\nU.S. B-LOC\n) O\n\nQualifier O\nvs. O\nPetr B-PER\nKorda I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n\nBohdan B-PER\nUlihrach I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nvs. O\n14 O\n- O\nAlberto B-PER\nCosta I-PER\n\n( O\nSpain B-LOC\n) O\n\n------------------------ O\n\n12 O\n- O\nTodd B-PER\nMartin I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nYounnes B-PER\nEl I-PER\nAynaoui I-PER\n( O\nMorocco B-LOC\n) O\n\nAndrea B-PER\nGaudenzi I-PER\n( O\nItaly B-LOC\n) O\nvs. O\nShuzo B-PER\nMatsuoka I-PER\n( O\nJapan B-LOC\n) O\n\nDoug B-PER\nFlach I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nqualifier O\n\nMats B-PER\nWilander I-PER\n( O\nSweden B-LOC\n) O\nvs. O\nTim B-PER\nHenman I-PER\n( O\nBritain B-LOC\n) O\n\nPaul B-PER\nHaarhuis I-PER\n( O\nNetherlands B-LOC\n) O\nvs. O\nMichael B-PER\nJoyce I-PER\n( O\nU.S. B-LOC\n) O\n\nMichael B-PER\nTebbutt I-PER\n( O\nAustralia B-LOC\n) O\nvs. O\nRichey B-PER\nReneberg I-PER\n( O\nU.S. B-LOC\n) O\n\nJonathan B-PER\nStark I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nBernd B-PER\nKarbacher I-PER\n( O\nGermany B-LOC\n) O\n\nStefan B-PER\nEdberg I-PER\n( O\nSweden B-LOC\n) O\nvs. O\n5 O\n- O\nRichard B-PER\nKrajicek I-PER\n( O\nNetherlands B-LOC\n) O\n\n------------------------ O\n\n6 O\n- O\nAndre B-PER\nAgassi I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nMauricio B-PER\nHadad I-PER\n( O\nColombia B-LOC\n) O\n\nMarcos B-PER\nOndruska I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nvs. O\nFelix B-PER\nMantilla I-PER\n( O\nSpain B-LOC\n) O\n\nCarlos B-PER\nMoya I-PER\n( O\nSpain B-LOC\n) O\nvs. O\nScott B-PER\nHumphries I-PER\n( O\nU.S. B-LOC\n) O\n\nJan B-PER\nSiemerink I-PER\n( O\nNetherlands B-LOC\n) O\nvs. O\nCarl-Uwe B-PER\nSteeb I-PER\n( O\nGermany B-LOC\n) O\n\nQualifier O\nvs. O\nqualifier O\n\nDavid B-PER\nWheaton I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nKevin B-PER\nKim I-PER\n( O\nU.S. B-LOC\n) O\n\nNicolas B-PER\nLapentti I-PER\n( O\nEcuador B-LOC\n) O\nvs. O\nAlex B-PER\nO'Brien I-PER\n( O\nU.S. B-LOC\n) O\n\nKarim B-PER\nAlami I-PER\n( O\nMorocco B-LOC\n) O\nvs. O\n11 O\n- O\nMaliVai B-PER\nWashington I-PER\n( O\nU.S. B-LOC\n) O\n\n------------------------ O\n\n13 O\n- O\nThomas B-PER\nEnqvist I-PER\n( O\nSweden B-LOC\n) O\nvs. O\nStephane B-PER\nSimian I-PER\n( O\nFrance B-LOC\n) O\n\nGuillaume B-PER\nRaoux I-PER\n( O\nFrance B-LOC\n) O\nvs. O\nFilip B-PER\nDewulf I-PER\n( O\nBelgium B-LOC\n) O\n\nMark B-PER\nKnowles I-PER\n( O\nBahamas B-LOC\n) O\nvs. O\nMarcelo B-PER\nFilippini I-PER\n( O\nUruguay B-LOC\n) O\n\nTodd B-PER\nWoodbridge I-PER\n( O\nAustralia B-LOC\n) O\nvs. O\nqualifier O\n\nKris B-PER\nGoossens I-PER\n( O\nBelgium B-LOC\n) O\nvs. O\nSergi B-PER\nBruguera I-PER\n( O\nSpain B-LOC\n) O\n\nQualifier O\nvs. O\nMichael B-PER\nStich I-PER\n( O\nGermany B-LOC\n) O\n\nQualifier O\nvs. O\nChuck B-PER\nAdams I-PER\n( O\nU.S. B-LOC\n) O\n\nJavier B-PER\nFrana I-PER\n( O\nArgentina B-LOC\n) O\nvs. O\n3 O\n- O\nThomas B-PER\nMuster I-PER\n( O\nAustria B-LOC\n) O\n\n------------------------ O\n\n8 O\n- O\nJim B-PER\nCourier I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nJavier B-PER\nSanchez I-PER\n( O\nSpain B-LOC\n) O\n\nJim B-PER\nGrabb I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nSandon B-PER\nStolle I-PER\n( O\nAustralia B-LOC\n) O\n\nPatrick B-PER\nRafter I-PER\n( O\nAustralia B-LOC\n) O\nvs. O\nKenneth B-PER\nCarlsen I-PER\n( O\nDenmark B-LOC\n) O\n\nJason B-PER\nStoltenberg I-PER\n( O\nAustralia B-LOC\n) O\nvs. O\nStefano B-PER\nPescosolido I-PER\n( O\nItaly B-LOC\n) O\n\nArnaud B-PER\nBoetsch I-PER\n( O\nFrance B-LOC\n) O\nvs. O\nNicolas B-PER\nPereira I-PER\n( O\nVenezuela B-LOC\n) O\n\nCarlos B-PER\nCosta I-PER\n( O\nSpain B-LOC\n) O\nvs. O\nMagnus B-PER\nGustafsson I-PER\n( O\nSweden B-LOC\n) O\n\nJeff B-PER\nTarango I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nAlex B-PER\nRadulescu I-PER\n( O\nGermany B-LOC\n) O\n\nQualifier O\nvs. O\n10 O\n- O\nMarcelo B-PER\nRios I-PER\n( O\nChile B-LOC\n) O\n\n------------------------ O\n\n15 O\n- O\nMarc B-PER\nRosset I-PER\n( O\nSwitzerland B-LOC\nvs. O\nJared B-PER\nPalmer I-PER\n( O\nU.S. B-LOC\n) O\n\nMartin B-PER\nDamm I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nvs. O\nHernan B-PER\nGumy I-PER\n( O\nArgentina B-LOC\n) O\n\nNicklas B-PER\nKulti I-PER\n( O\nSweden B-LOC\n) O\nvs. O\nJakob B-PER\nHlasek I-PER\n( O\nSwitzerland B-LOC\n) O\n\nCecil B-PER\nMamiit I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nAlberto B-PER\nBerasategui I-PER\n( O\nSpain B-LOC\n) O\n\nVince B-PER\nSpadea I-PER\n( O\nU.S. B-LOC\n) O\nvs. O\nDaniel B-PER\nVacek I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n\nDavid B-PER\nPrinosil I-PER\n( O\nGermany B-LOC\n) O\nvs. O\nqualifier O\n\nQualifier O\nvs. O\nTomas B-PER\nCarbonell I-PER\n( O\nSpain B-LOC\n) O\n\nQualifier O\nvs. O\n2 O\n- O\nMichael B-PER\nChang I-PER\n( O\nU.S. B-LOC\n) O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nORIOLES B-ORG\n' O\nMANAGER O\nDAVEY B-PER\nJOHNSON I-PER\nHOSPITALIZED O\n. O\n\nBALTIMORE B-LOC\n1996-08-22 O\n\nBaltimore B-ORG\nOrioles I-ORG\nmanager O\nDavey B-PER\nJohnson I-PER\nwill O\nmiss O\nThursday O\nnight O\n's O\ngame O\nagainst O\nthe O\nSeattle B-ORG\nMariners I-ORG\nafter O\nbeing O\nadmitted O\nto O\na O\nhospital O\nwith O\nan O\nirregular O\nheartbeat O\n. O\n\nThe O\n53-year-old O\nJohnson B-PER\nwas O\nhospitalized O\nafter O\nexperiencing O\ndizziness O\n. O\n\n\" O\nHe O\nis O\nin O\nno O\ndanger O\nand O\nwill O\nbe O\ntreated O\nand O\nobserved O\nthis O\nevening O\n, O\n\" O\nsaid O\nOrioles B-ORG\nteam O\nphysician O\nDr. O\nWilliam B-PER\nGoldiner I-PER\n, O\nadding O\nthat O\nJohnson B-PER\nis O\nexpected O\nto O\nbe O\nreleased O\non O\nFriday O\n. O\n\nOrioles B-ORG\n' O\nbench O\ncoach O\nAndy B-PER\nEtchebarren I-PER\nwill O\nmanage O\nthe O\nclub O\nin O\nJohnson B-PER\n's O\nabsence O\n. O\n\nJohnson B-PER\nis O\nthe O\nsecond O\nmanager O\nto O\nbe O\nhospitalized O\nthis O\nweek O\nafter O\nCalifornia B-ORG\nAngels I-ORG\nskipper O\nJohn B-PER\nMcNamara I-PER\nwas O\nadmitted O\nto O\nNew B-LOC\nYork I-LOC\n's O\nColumbia B-LOC\nPresbyterian I-LOC\nHospital I-LOC\non O\nWednesday O\nwith O\na O\nblood O\nclot O\nin O\nhis O\nleft O\ncalf O\n. O\n\nJohnson B-PER\n, O\nwho O\nplayed O\neight O\nseasons O\nin O\nBaltimore B-LOC\n, O\nwas O\nnamed O\nOrioles B-ORG\nmanager O\nin O\nthe O\noff-season O\nreplacing O\nPhil B-PER\nRegan I-PER\n. O\n\nHe O\nled O\nthe O\nCincinnati B-ORG\nReds I-ORG\nto O\nthe O\nNational B-MISC\nLeague I-MISC\nChampionship I-MISC\nSeries I-MISC\nlast O\nyear O\nand O\nguided O\nthe O\nNew B-ORG\nYork I-ORG\nMets I-ORG\nto O\na O\nWorld B-MISC\nSeries I-MISC\nchampionship O\nin O\n1986 O\n. O\n\nBaltimore B-ORG\nhas O\nwon O\n16 O\nof O\nits O\nlast O\n22 O\ngames O\nto O\npull O\nwithin O\nfive O\ngames O\nof O\nthe O\nslumping O\nNew B-ORG\nYork I-ORG\nYankees I-ORG\nin O\nthe O\nAmerican B-MISC\nLeague I-MISC\nEast I-MISC\nDivision I-MISC\n. O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nWEDNESDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-22 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nWednesday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n72 O\n53 O\n.576 O\n- O\n\nBALTIMORE B-ORG\n67 O\n58 O\n.536 O\n5 O\n\nBOSTON B-ORG\n63 O\n64 O\n.496 O\n10 O\n\nTORONTO B-ORG\n58 O\n69 O\n.457 O\n15 O\n\nDETROIT B-ORG\n44 O\n82 O\n.349 O\n28 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n76 O\n51 O\n.598 O\n- O\n\nCHICAGO B-ORG\n69 O\n59 O\n.539 O\n7 O\n1/2 O\n\nMINNESOTA B-ORG\n63 O\n63 O\n.500 O\n12 O\n1/2 O\n\nMILWAUKEE B-ORG\n60 O\n68 O\n.469 O\n16 O\n1/2 O\n\nKANSAS B-ORG\nCITY I-ORG\n58 O\n70 O\n.453 O\n18 O\n1/2 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n73 O\n54 O\n.575 O\n- O\n\nSEATTLE B-ORG\n64 O\n61 O\n.512 O\n8 O\n\nOAKLAND B-ORG\n62 O\n67 O\n.481 O\n12 O\n\nCALIFORNIA B-ORG\n58 O\n68 O\n.460 O\n14 O\n1/2 O\n\nTHURSDAY O\n, O\nAUGUST O\n22 O\nSCHEDULE O\n\nOAKLAND B-ORG\nAT O\nBOSTON B-LOC\n\nSEATTLE B-ORG\nAT O\nBALTIMORE B-LOC\n\nCALIFORNIA B-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nTORONTO B-ORG\nAT O\nCHICAGO B-LOC\n\nDETROIT B-ORG\nAT O\nKANSAS B-LOC\nCITY I-LOC\n\nTEXAS B-ORG\nAT O\nMINNESOTA B-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n79 O\n46 O\n.632 O\n- O\n\nMONTREAL B-ORG\n67 O\n58 O\n.536 O\n12 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n69 O\n.461 O\n21 O\n1/2 O\n\nFLORIDA B-ORG\n58 O\n69 O\n.457 O\n22 O\n\nPHILADELPHIA B-ORG\n52 O\n75 O\n.409 O\n28 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nHOUSTON B-ORG\n68 O\n59 O\n.535 O\n- O\n\nST B-ORG\nLOUIS I-ORG\n67 O\n59 O\n.532 O\n1/2 O\n\nCHICAGO B-ORG\n63 O\n62 O\n.504 O\n4 O\n\nCINCINNATI B-ORG\n62 O\n62 O\n.500 O\n4 O\n1/2 O\n\nPITTSBURGH B-ORG\n53 O\n73 O\n.421 O\n14 O\n1/2 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n70 O\n59 O\n.543 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n66 O\n60 O\n.524 O\n2 O\n1/2 O\n\nCOLORADO B-ORG\n65 O\n62 O\n.512 O\n4 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n54 O\n70 O\n.435 O\n13 O\n1/2 O\n\nTHURSDAY O\n, O\nAUGUST O\n22 O\nSCHEDULE O\n\nST B-ORG\nLOUIS I-ORG\nAT O\nCOLORADO B-LOC\n\nCINCINNATI B-ORG\nAT O\nATLANTA B-LOC\n\nPITTSBURGH B-ORG\nAT O\nHOUSTON B-LOC\n\nPHILADELPHIA B-ORG\nAT O\nLOS B-LOC\nANGELES I-LOC\n\nMONTREAL B-ORG\nAT O\nSAN B-LOC\nFRANCISCO I-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nWEDNESDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-22 O\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\n\nBaseball O\ngames O\nplayed O\non O\nWednesday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nAmerican B-MISC\nLeague I-MISC\n\nCalifornia B-ORG\n7 O\nNEW B-ORG\nYORK I-ORG\n1 O\n\nDETROIT B-ORG\n7 O\nChicago B-ORG\n4 O\n\nMilwaukee B-ORG\n10 O\nMINNESOTA B-ORG\n7 O\n\nBOSTON B-ORG\n6 O\nOakland B-ORG\n4 O\n\nBALTIMORE B-ORG\n10 O\nSeattle B-ORG\n5 O\n\nTexas B-ORG\n10 O\nCLEVELAND B-ORG\n8 O\n( O\nin O\n10 O\n) O\n\nToronto B-ORG\n6 O\nKANSAS B-ORG\nCITY I-ORG\n2 O\n\nNational B-MISC\nLeague I-MISC\n\nCHICAGO B-ORG\n8 O\nFlorida B-ORG\n3 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n12 O\nNew B-ORG\nYork I-ORG\n11 O\n\nATLANTA B-ORG\n4 O\nCincinnati B-ORG\n3 O\n\nPittsburgh B-ORG\n5 O\nHOUSTON B-ORG\n2 O\n\nCOLORADO B-ORG\n10 O\nSt B-ORG\nLouis I-ORG\n2 O\n\nPhiladelphia B-ORG\n6 O\nLOS B-ORG\nANGELES I-ORG\n0 O\n\nSAN B-ORG\nDIEGO I-ORG\n7 O\nMontreal B-ORG\n2 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nGREER B-PER\nHOMER O\nIN O\n10TH O\nLIFTS O\nTEXAS B-ORG\nPAST O\nINDIANS B-ORG\n. O\n\nCLEVELAND B-LOC\n1996-08-22 O\n\nRusty B-PER\nGreer I-PER\n's O\ntwo-run O\nhomer O\nin O\nthe O\ntop O\nof O\nthe O\n10th O\ninning O\nrallied O\nthe O\nTexas B-ORG\nRangers I-ORG\nto O\na O\n10-8 O\nvictory O\nover O\nthe O\nCleveland B-ORG\nIndians I-ORG\nWednesday O\nin O\nthe O\nrubber O\ngame O\nof O\na O\nthree-game O\nseries O\nbetween O\ndivision O\nleaders O\n. O\n\nWith O\none O\nout O\n, O\nGreer B-PER\nhit O\na O\n1-1 O\npitch O\nfrom O\nJulian B-PER\nTavarez I-PER\n( O\n4-7 O\n) O\nover O\nthe O\nright-field O\nfence O\nfor O\nhis O\n15th O\nhome O\nrun O\n. O\n\n\" O\nIt O\nwas O\nan O\noff-speed O\npitch O\nand O\nI O\njust O\ntried O\nto O\nget O\na O\ngood O\nswing O\non O\nit O\nand O\nput O\nit O\nin O\nplay O\n, O\n\" O\nGreer B-PER\nsaid O\n. O\n\" O\n\nThis O\nwas O\na O\nbig O\ngame O\n. O\n\nThe O\ncrowd O\nwas O\nbehind O\nhim O\nand O\nit O\nwas O\nintense O\n. O\n\" O\n\nThe O\nshot O\nbrought O\nhome O\nIvan B-PER\nRodriguez I-PER\n, O\nwho O\nhad O\nhis O\nsecond O\ndouble O\nof O\nthe O\ngame O\n, O\ngiving O\nhim O\n42 O\nthis O\nseason O\n, O\n41 O\nas O\na O\ncatcher O\n. O\n\nHe O\njoined O\nMickey B-PER\nCochrane I-PER\n, O\nJohnny B-PER\nBench I-PER\nand O\nTerry B-PER\nKennedy I-PER\nas O\nthe O\nonly O\ncatchers O\nwith O\n40 O\ndoubles O\nin O\na O\nseason O\n. O\n\nThe O\nRangers B-ORG\nhave O\nwon O\n10 O\nof O\ntheir O\nlast O\n12 O\ngames O\nand O\nsix O\nof O\nnine O\nmeetings O\nagainst O\nthe O\nIndians B-ORG\nthis O\nseason O\n. O\n\nThe O\nAmerican B-MISC\nLeague I-MISC\nWestern I-MISC\nleaders O\nhave O\nwon O\neight O\nof O\n15 O\ngames O\nat O\nJacobs B-LOC\nField I-LOC\n, O\njoining O\nthe O\nYankees B-ORG\nas O\nthe O\nonly O\nteams O\nwith O\na O\nwinning O\nrecord O\nat O\nthe O\nA.L. B-MISC\nCentral I-MISC\nleaders O\n' O\nhome O\n. O\n\nCleveland B-ORG\nlost O\nfor O\njust O\nthe O\nsecond O\ntime O\nin O\nsix O\ngames O\n. O\n\nThe O\nIndians B-ORG\nsent O\nthe O\ngame O\ninto O\nextra O\ninnings O\nin O\nthe O\nninth O\non O\nKenny B-PER\nLofton I-PER\n's O\ntwo-run O\nsingle O\n. O\n\nEd B-PER\nVosberg I-PER\n( O\n1-0 O\n) O\nblew O\nhis O\nfirst O\nsave O\nopportunity O\nbut O\ngot O\nthe O\nwin O\n, O\nallowing O\nthree O\nhits O\nwith O\ntwo O\nwalks O\nand O\nthree O\nstrikeouts O\nin O\n1 O\n2/3 O\nscoreless O\ninnings O\n. O\n\nDean B-PER\nPalmer I-PER\nhit O\nhis O\n30th O\nhomer O\nfor O\nthe O\nRangers B-ORG\n. O\n\nIn O\nBaltimore B-LOC\n, O\nCal B-PER\nRipken I-PER\nhad O\nfour O\nhits O\nand O\nsnapped O\na O\nfifth-inning O\ntie O\nwith O\na O\nsolo O\nhomer O\nand O\nBobby B-PER\nBonilla I-PER\nadded O\na O\nthree-run O\nshot O\nin O\nthe O\nseventh O\nto O\npower O\nthe O\nsurging O\nOrioles B-ORG\nto O\na O\n10-5 O\nvictory O\nover O\nthe O\nSeattle B-ORG\nMariners I-ORG\n. O\n\nThe O\nMariners B-ORG\nscored O\nfour O\nruns O\nin O\nthe O\ntop O\nof O\nthe O\nfifth O\nto O\ntie O\nthe O\ngame O\n5-5 O\nbut O\nRipken B-PER\nled O\noff O\nthe O\nbottom O\nof O\nthe O\ninning O\nwith O\nhis O\n21st O\nhomer O\noff O\nstarter O\nSterling B-PER\nHitchcock I-PER\n( O\n12-6 O\n) O\n. O\n\nBonilla B-PER\n's O\nblast O\nwas O\nthe O\nfirst O\ntime O\nRandy B-PER\nJohnson I-PER\n, O\nlast O\nseason O\n's O\nCy B-PER\nYoung I-PER\nwinner O\n, O\nallowed O\na O\nrun O\nin O\nfive O\nrelief O\nappearances O\nsince O\ncoming O\noff O\nthe O\ndisabled O\nlist O\non O\nAugust O\n6 O\n. O\n\nBonilla B-PER\nhas O\n21 O\nRBI B-MISC\nand O\n15 O\nruns O\nin O\nhis O\nlast O\n20 O\ngames O\n. O\n\nBaltimore B-LOC\nhas O\nwon O\nseven O\nof O\nnine O\nand O\n16 O\nof O\nits O\nlast O\n22 O\nand O\ncut O\nthe O\nYankees B-ORG\n' O\nlead O\nin O\nthe O\nA.L. B-MISC\nEast I-MISC\nto O\nfive O\ngames O\n. O\n\nScott B-PER\nErickson I-PER\n( O\n8-10 O\n) O\nlaboured O\nto O\nhis O\nthird O\nstraight O\nwin O\n. O\n\nAlex B-PER\nRodriguez I-PER\nhad O\ntwo O\nhomers O\nand O\nfour O\nRBI B-MISC\nfor O\nthe O\nMariners B-ORG\n, O\nwho O\nhave O\ndropped O\nthree O\nin O\na O\nrow O\nand O\n11 O\nof O\n15 O\n. O\n\nHe O\nbecame O\nthe O\nfifth O\nshortstop O\nin O\nmajor-league O\nhistory O\nto O\nhit O\n30 O\nhomers O\nin O\na O\nseason O\nand O\nthe O\nfirst O\nsince O\nRipken B-PER\nhit O\n34 O\nin O\n1991 O\n. O\n\nChris B-PER\nHoiles I-PER\nhit O\nhis O\n22nd O\nhomer O\nfor O\nBaltimore B-LOC\n. O\n\nIn O\nNew B-LOC\nYork I-LOC\n, O\nJason B-PER\nDickson I-PER\nscattered O\n10 O\nhits O\nover O\n6 O\n1/3 O\ninnings O\nin O\nhis O\nmajor-league O\ndebut O\nand O\nChili B-PER\nDavis I-PER\nbelted O\na O\nhomer O\nfrom O\neach O\nside O\nof O\nthe O\nplate O\nas O\nthe O\nCalifornia B-ORG\nAngels I-ORG\ndefeated O\nthe O\nYankees B-ORG\n7-1 O\n. O\n\nDickson B-PER\nallowed O\na O\nhomer O\nto O\nDerek B-PER\nJeter I-PER\non O\nhis O\nfirst O\nmajor-league O\npitch O\nbut O\nsettled O\ndown O\n. O\n\nHe O\nwas O\nthe O\n27th O\npitcher O\nused O\nby O\nthe O\nAngels B-ORG\nthis O\nseason O\n, O\ntying O\na O\nmajor-league O\nrecord O\n. O\n\nJimmy B-PER\nKey I-PER\n( O\n9-10 O\n) O\ntook O\nthe O\nloss O\nas O\nthe O\nYankees B-ORG\nlost O\ntheir O\nninth O\nin O\n14 O\ngames O\n. O\n\nThey O\nstranded O\n11 O\nbaserunners O\n. O\n\nCalifornia B-LOC\nplayed O\nwithout O\ninterim O\nmanager O\nJohn B-PER\nMcNamara I-PER\n, O\nwho O\nwas O\nadmitted O\nto O\na O\nNew B-LOC\nYork I-LOC\nhospital O\nwith O\na O\nblood O\nclot O\nin O\nhis O\nright O\ncalf O\n. O\n\nIn O\nBoston B-LOC\n, O\nMike B-PER\nStanley I-PER\n's O\nbases-loaded O\ntwo-run O\nsingle O\nsnapped O\nan O\neighth-inning O\ntie O\nand O\ngave O\nthe O\nRed B-ORG\nSox I-ORG\ntheir O\nthird O\nstraight O\nwin O\n, O\n6-4 O\nover O\nthe O\nOakland B-ORG\nAthletics I-ORG\n. O\n\nStanley B-PER\nowns O\na O\n.367 O\ncareer O\nbatting O\naverage O\nwith O\nthe O\nbases O\nloaded O\n( O\n33-for-90 O\n) O\n. O\n\nBoston B-LOC\n's O\nMo B-PER\nVaughn I-PER\nwent O\n3-for-3 O\nwith O\na O\nwalk O\n, O\nstole O\nhome O\nfor O\none O\nof O\nhis O\nthree O\nruns O\nscored O\nand O\ncollected O\nhis O\n116th O\nRBI B-MISC\n. O\n\nScott B-PER\nBrosius I-PER\nhomered O\nand O\ndrove O\nin O\ntwo O\nruns O\nfor O\nthe O\nAthletics B-ORG\n, O\nwho O\nhave O\nlost O\nseven O\nof O\ntheir O\nlast O\nnine O\ngames O\n. O\n\nIn O\nDetroit B-LOC\n, O\nBrad B-PER\nAusmus I-PER\n's O\nthree-run O\nhomer O\ncapped O\na O\nfour-run O\neighth O\nand O\nlifted O\nthe O\nTigers B-ORG\nto O\na O\n7-4 O\nvictory O\nover O\nthe O\nreeling O\nChicago B-ORG\nWhite I-ORG\nSox I-ORG\n. O\n\nThe O\nTigers B-ORG\nhave O\nwon O\nconsecutive O\ngames O\nafter O\ndropping O\neight O\nin O\na O\nrow O\n, O\nbut O\nhave O\nwon O\nnine O\nof O\ntheir O\nlast O\n12 O\nat O\nhome O\n. O\n\nThe O\nWhite B-ORG\nSox I-ORG\nhave O\nlost O\nsix O\nof O\ntheir O\nlast O\neight O\ngames O\n. O\n\nIn O\nKansas B-LOC\nCity I-LOC\n, O\nJuan B-PER\nGuzman I-PER\ntossed O\na O\ncomplete-game O\nsix-hitter O\nto O\nwin O\nfor O\nthe O\nfirst O\ntime O\nin O\nover O\na O\nmonth O\nand O\nlower O\nhis O\nleague-best O\nERA B-MISC\nas O\nthe O\nToronto B-ORG\nBlue I-ORG\nJays I-ORG\nwon O\ntheir O\nfourth O\nstraight O\n, O\n6-2 O\nover O\nthe O\nRoyals B-ORG\n. O\n\nGuzman B-PER\n( O\n10-8 O\n) O\nwon O\nfor O\nthe O\nfirst O\ntime O\nsince O\nJuly O\n16 O\n, O\na O\nspan O\nof O\nsix O\nstarts O\n. O\n\nHe O\nallowed O\ntwo O\nruns O\n-- O\none O\nearned O\n-- O\nand O\nlowered O\nhis O\nERA B-MISC\nto O\n2.99 O\n. O\n\nAt O\nMinnesota B-LOC\n, O\nJohn B-PER\nJaha I-PER\n's O\nthree-run O\nhomer O\n, O\nhis O\n26th O\n, O\ncapped O\na O\nfive-run O\neighth O\ninning O\nthat O\nrallied O\nthe O\nMilwaukee B-ORG\nBrewers I-ORG\nto O\na O\n10-7 O\nvictory O\nover O\nthe O\nTwins B-ORG\n. O\n\nJaha B-PER\nadded O\nan O\nRBI B-MISC\nsingle O\nin O\nthe O\nninth O\nand O\nhad O\nfour O\nRBI B-MISC\n. O\n\nJose B-PER\nValentin I-PER\nhit O\nhis O\n21st O\nhomer O\nfor O\nMilwaukee B-ORG\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nCOCU B-PER\nDOUBLE O\nEARNS O\nPSV B-ORG\n4-1 O\nWIN O\n. O\n\nAMSTERDAM B-LOC\n1996-08-22 O\n\nPhilip B-PER\nCocu I-PER\nscored O\ntwice O\nin O\nthe O\nsecond O\nhalf O\nto O\nspur O\nPSV B-ORG\nEindhoven I-ORG\nto O\na O\n4-1 O\naway O\nwin O\nover O\nNEC B-ORG\nNijmegen I-ORG\nin O\nthe O\nDutch B-MISC\nfirst O\ndivision O\non O\nThursday O\n. O\n\nHe O\nscored O\nfrom O\nclose O\nrange O\nin O\nthe O\n54th O\nminute O\nand O\nfrom O\na O\nbicycle O\nkick O\n13 O\nminutes O\nlater O\n. O\n\nArthur B-PER\nNuman I-PER\nand O\nLuc B-PER\nNilis I-PER\n, O\nDutch B-MISC\ntop O\nscorer O\nlast O\nseason O\n, O\nwere O\nPSV B-ORG\n's O\nother O\nmarksmen O\n. O\n\nAjax B-ORG\nAmsterdam I-ORG\nopened O\ntheir O\ntitle O\ndefence O\nwith O\na O\n1-0 O\nwin O\nover O\nNAC B-ORG\nBreda I-ORG\non O\nWednesday O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nSUMMARY O\n. O\n\nAMSTERDAM B-LOC\n1996-08-22 O\n\nSummary O\nof O\nThursday O\n's O\nonly O\n\nDutch B-MISC\nfirst O\ndivision O\nmatch O\n: O\n\nNEC B-ORG\nNijmegen I-ORG\n1 O\n( O\nVan O\nEykeren O\n15th O\n) O\nPSV B-ORG\nEindhoven I-ORG\n4 O\n( O\nNuman O\n11th O\n, O\n\nNilis B-PER\n42nd O\n, O\nCocu B-PER\n54th O\n, O\n67th O\n) O\n. O\n\nHalftime O\n1-2 O\n. O\n\nAttendance O\n8,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nRESULT O\n. O\n\nAMSTERDAM B-LOC\n1996-08-22 O\n\nResult O\nof O\na O\nDutch B-MISC\nfirst O\n\ndivision O\nmatch O\non O\nThursday O\n: O\n\nNEC B-ORG\nNijmegen I-ORG\n1 O\nPSV B-ORG\nEindhoven I-ORG\n4 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSHARPSHOOTER O\nKNUP B-PER\nBACK O\nIN O\nSWISS B-MISC\nSQUAD O\n. O\n\nGENEVA B-LOC\n1996-08-22 O\n\nGalatasaray B-ORG\nstriker O\nAdrian B-PER\nKnup I-PER\n, O\nscorer O\nof O\n26 O\ngoals O\nin O\n45 O\ninternationals O\n, O\nhas O\nbeen O\nrecalled O\nby O\nSwitzerland B-LOC\nfor O\nthe O\nWorld B-MISC\nCup I-MISC\nqualifier O\nagainst O\nAzerbaijan B-LOC\nin O\nBaku B-LOC\non O\nAugust O\n31 O\n. O\n\nKnup B-PER\nwas O\noverlooked O\nby O\nArtur B-PER\nJorge I-PER\nfor O\nthe O\nEuropean B-MISC\nchampionship O\nfinals O\nearlier O\nthis O\nyear O\n. O\n\nBut O\nnew O\ncoach O\nRolf B-PER\nFringer I-PER\nis O\nclearly O\na O\nKnup B-PER\nfan O\nand O\nincluded O\nhim O\nin O\nhis O\n19-man O\nsquad O\non O\nThursday O\n. O\n\nSwitzerland B-LOC\nfailed O\nto O\nprogress O\nbeyond O\nthe O\nopening O\ngroup O\nphase O\nin O\nEuro B-MISC\n96 I-MISC\n. O\n\nSquad O\n: O\n\nGoalkeepers O\n- O\nMarco B-PER\nPascolo I-PER\n( O\nCagliari B-ORG\n) O\n, O\nPascal B-PER\nZuberbuehler I-PER\n( O\nGrasshoppers B-ORG\n) O\n. O\n\nDefenders O\n- O\nStephane B-PER\nHenchoz I-PER\n( O\nHamburg B-ORG\n) O\n, O\nMarc B-PER\nHottiger I-PER\n( O\nEverton B-ORG\n) O\n, O\nYvan B-PER\nQuentin I-PER\n( O\nSion B-ORG\n) O\n, O\nRamon B-PER\nVega I-PER\n( O\nCagliari B-ORG\n) O\nRaphael B-PER\nWicky I-PER\n( O\nSion B-ORG\n) O\n. O\n\nMidfielders O\n- O\nAlexandre B-PER\nComisetti I-PER\n( O\nGrasshoppers B-ORG\n) O\n, O\nAntonio B-PER\nEsposito I-PER\n( O\nGrasshoppers B-ORG\n) O\n, O\nSebastien B-PER\nFournier I-PER\n( O\nStuttgart B-LOC\n) O\n, O\nChristophe B-PER\nOhrel I-PER\n( O\nLausanne B-LOC\n) O\n, O\nPatrick B-PER\nSylvestre I-PER\n( O\nSion B-ORG\n) O\n, O\nDavid B-PER\nSesa I-PER\n( O\nServette B-ORG\n) O\n, O\nCiriaco B-PER\nSforza I-PER\n( O\nInter B-ORG\nMilan I-ORG\n) O\nMurat B-PER\nYakin I-PER\n( O\nGrasshoppers B-ORG\n) O\n. O\n\nStrikers O\n- O\nKubilay B-PER\nTurkyilmaz I-PER\n( O\nGrasshoppers B-ORG\n) O\n, O\nAdrian B-PER\nKnup I-PER\n( O\nGalatasaray B-ORG\n) O\n, O\nChristophe B-PER\nBonvin I-PER\n( O\nSion B-ORG\n) O\n, O\nStephane B-PER\nChapuisat I-PER\n( O\nBorussia B-ORG\nDortmund I-ORG\n) O\n. O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nIT O\n'S O\nA O\nRECORD O\n- O\n40,000 O\nBEERS O\nON O\nTHE O\nHOUSE O\n. O\n\nBRUSSELS B-LOC\n1996-08-22 O\n\nSpectators O\nat O\nFriday O\n's O\nBrussels B-LOC\ngrand O\nprix O\nmeeting O\nhave O\nan O\nextra O\nincentive O\nto O\ncheer O\non O\nthe O\nathletes O\nto O\nworld O\nrecord O\nperformances O\n-- O\na O\nfree O\nglass O\nof O\nbeer O\n. O\n\nA O\nBelgian B-MISC\nbrewery O\nhas O\noffered O\nto O\npay O\nfor O\na O\nfree O\nround O\nof O\ndrinks O\nfor O\nall O\nof O\nthe O\n40,000 O\ncrowd O\nif O\na O\nworld O\nrecord O\ngoes O\nat O\nthe O\nmeeting O\n, O\norganisers O\nsaid O\non O\nThursday O\n. O\n\nIt O\ncould O\nbe O\none O\nof O\nthe O\nmost O\nexpensive O\nrounds O\nof O\ndrinks O\never O\n. O\n\nThe O\nmeeting O\nis O\nsold O\nout O\nalready O\n. O\n\nTwo O\nworld O\nrecords O\nare O\nin O\nserious O\ndanger O\nof O\nbeing O\nbroken O\nat O\nthe O\nmeeting O\n-- O\nthe O\nwomen O\n's O\n1,000 O\nmetres O\nand O\nthe O\nmen O\n's O\n3,000 O\nmetres O\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nGERMAN B-MISC\nOPEN I-MISC\nFIRST O\nROUND O\nSCORES O\n. O\n\nSTUTTGART B-LOC\n, O\nGermany B-LOC\n1996-08-22 O\n\nLeading O\nfirst O\nround O\n\nscores O\nin O\nthe O\nGerman B-MISC\nOpen I-MISC\ngolf O\nchampionship O\non O\nThursday O\n( O\nBritain B-LOC\n\nunless O\nstated O\n) O\n: O\n\n62 O\nPaul B-PER\nBroadhurst I-PER\n\n63 O\nRaymond B-PER\nRussell I-PER\n\n64 O\nDavid B-PER\nJ. I-PER\nRussell I-PER\n, O\nMichael B-PER\nCampbell I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n, O\nIan B-PER\n\nWoosnam B-PER\n, O\nBernhard B-PER\nLanger I-PER\n( O\nGermany B-LOC\n) O\n, O\nRonan B-PER\nRafferty I-PER\n, O\nMats B-PER\n\nLanner B-PER\n( O\nSweden B-LOC\n) O\n, O\nWayne B-PER\nRiley I-PER\n( O\nAustralia B-LOC\n) O\n\n65 O\nEamonn B-PER\nDarcy I-PER\n( O\nIreland B-LOC\n) O\n, O\nPer B-PER\nNyman I-PER\n( O\nSweden B-LOC\n) O\n, O\nRussell B-PER\nClaydon I-PER\n, O\n\nMark B-PER\nRoe I-PER\n, O\nRetief B-PER\nGoosen I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n, O\nCarl B-PER\nSuneson I-PER\n\n66 O\nStephen B-PER\nField I-PER\n, O\nPaul B-PER\nLawrie I-PER\n, O\nIan B-PER\nPyman I-PER\n, O\nMax B-PER\nAnglert I-PER\n\n( O\nSweden B-LOC\n) O\n, O\nMiles B-PER\nTunnicliff I-PER\n, O\nChristian B-PER\nCevaer I-PER\n( O\nFrance B-LOC\n) O\n, O\n\nDes B-PER\nSmyth I-PER\n( O\nIreland B-LOC\n) O\n, O\nDavid B-PER\nCarter I-PER\n, O\nLee B-PER\nWestwood I-PER\n, O\nGreg B-PER\n\nChalmers B-PER\n( O\nAustralia B-LOC\n) O\n, O\nMiguel B-PER\nAngel I-PER\nMartin I-PER\n( O\nSpain B-LOC\n) O\n, O\n\nThomas B-PER\nBjorn I-PER\n( O\nDenmark B-LOC\n) O\n, O\nFernando B-PER\nRoca I-PER\n( O\nSpain B-LOC\n) O\n, O\nDerrick B-PER\n\nCooper B-PER\n\n67 O\nJeff B-PER\nHawksworth I-PER\n, O\nPadraig B-PER\nHarrington I-PER\n( O\nIreland B-LOC\n) O\n, O\nMichael B-PER\n\nWelch B-PER\n, O\nThomas B-PER\nGogele I-PER\n( O\nGermany B-LOC\n) O\n, O\nPaul B-PER\nMcGinley I-PER\n( O\nIreland B-LOC\n) O\n, O\n\nGary B-PER\nOrr I-PER\n, O\nJose-Maria B-PER\nCanizares I-PER\n( O\nSpain B-LOC\n) O\n, O\nMichael B-PER\nJonzon I-PER\n\n( O\nSweden B-LOC\n) O\n, O\nPaul B-PER\nEales I-PER\n, O\nDavid B-PER\nWilliams I-PER\n, O\nAndrew B-PER\nColtart I-PER\n, O\n\nJonathan B-PER\nLomas I-PER\n, O\nJose B-PER\nRivero I-PER\n( O\nSpain B-LOC\n) O\n, O\nRobert B-PER\nKarlsson I-PER\n\n( O\nSweden B-LOC\n) O\n, O\nMarcus B-PER\nWills I-PER\n, O\nPedro B-PER\nLinhart I-PER\n( O\nSpain B-LOC\n) O\n, O\nJamie B-PER\n\nSpence B-PER\n, O\nTerry B-PER\nPrice I-PER\n( O\nAustralia B-LOC\n) O\n, O\nJuan B-PER\nCarlos I-PER\nPinero I-PER\n( O\nSpain B-LOC\n) O\n, O\n\nMark B-PER\nMouland I-PER\n\n-DOCSTART- O\n\nSOCCER O\n- O\nUEFA B-ORG\nREWARDS O\nTHREE O\nCOUNTRIES O\nFOR O\nFAIR O\nPLAY O\n. O\n\nGENEVA B-LOC\n1996-08-22 O\n\nNorway B-LOC\n, O\nEngland B-LOC\nand O\nSweden B-LOC\nwere O\nrewarded O\nfor O\ntheir O\nfair O\nplay O\non O\nThursday O\nwith O\nan O\nadditional O\nplace O\nin O\nthe O\n1997-98 O\nUEFA B-MISC\nCup I-MISC\ncompetition O\n. O\n\nNorway B-LOC\nheaded O\nthe O\nUEFA B-MISC\nFair I-MISC\nPlay I-MISC\nrankings O\nfor O\n1995-96 O\nwith O\n8.62 O\npoints O\n, O\nahead O\nof O\nEngland B-LOC\nwith O\n8.61 O\nand O\nSweden B-LOC\n8.57 O\n. O\n\nThe O\nrankings O\nare O\nbased O\non O\na O\nformula O\nthat O\ntakes O\ninto O\naccount O\nmany O\nfactors O\nincluding O\nred O\nand O\nyellow O\ncards O\n, O\nand O\ncoaching O\nand O\nspectators O\n' O\nbehaviour O\nat O\nmatches O\nplayed O\nat O\nan O\ninternational O\nlevel O\nby O\nclubs O\nand O\nnational O\nteams O\n. O\n\nOnly O\nthe O\ntop O\nthree O\ncountries O\nare O\nallocated O\nadditional O\nplaces O\n. O\n\nThe O\nUEFA B-MISC\nFair I-MISC\nPlay I-MISC\nrankings O\nare O\n: O\n1 O\n. O\n\nNorway B-LOC\n8.62 O\npoints O\n\n2. O\nEngland B-LOC\n8.61 O\n\n3. O\nSweden B-LOC\n8.57 O\n\n4. O\nFaroe B-LOC\nIslands I-LOC\n8.56 O\n\n5. O\nWales B-LOC\n8.54 O\n\n6. O\nEstonia B-LOC\n8.52 O\n\n7. O\nIreland B-LOC\n8.45 O\n\n8. O\nBelarus B-LOC\n8.39 O\n\n9. O\nIceland B-LOC\n8.35 O\n\n10. O\nNetherlands B-LOC\n8.30 O\n\n10. O\nDenmark B-LOC\n8.30 O\n\n10. O\nGermany B-LOC\n8.30 O\n\n13. O\nScotland B-LOC\n8.29 O\n\n13. O\nLatvia B-LOC\n8.29 O\n\n15. O\nMoldova B-LOC\n8.24 O\n\n16. O\nYugoslavia B-LOC\n8.22 O\n\n16. O\nBelgium B-LOC\n8.22 O\n\n18. O\nLuxembourg B-LOC\n8.20 O\n\n19. O\nFrance B-LOC\n8.18 O\n\n20. O\nIsrael B-LOC\n8.17 O\n\n21. O\nSwitzerland B-LOC\n8.15 O\n\n21. O\nSlovakia B-LOC\n8.15 O\n\n23. O\nPoland B-LOC\n8.12 O\n\n23. O\nPortugal B-LOC\n8.12 O\n\n25. O\nGeorgia B-LOC\n8.10 O\n\n26. O\nUkraine B-LOC\n8.09 O\n\n26. O\nSpain B-LOC\n8.09 O\n\n26. O\nFinland B-LOC\n8.09 O\n\n29. O\nMacedonia B-LOC\n8.07 O\n\n30. O\nLithuania B-LOC\n8.06 O\n\n31. O\nAustria B-LOC\n8.05 O\n\n32. O\nRussia B-LOC\n8.03 O\n\n33. O\nRomania B-LOC\n8.02 O\n\n33. O\nTurkey B-LOC\n8.02 O\n\n35. O\nHungary B-LOC\n7.98 O\n\n36. O\nCzech B-LOC\nRepublic I-LOC\n7.95 O\n\n37. O\nGreece B-LOC\n7.89 O\n\n37. O\nNorthern B-LOC\nIreland I-LOC\n7.89 O\n\n39. O\nItaly B-LOC\n7.85 O\n\n40. O\nCyprus B-LOC\n7.83 O\n\n41. O\nArmenia B-LOC\n7.80 O\n\n42. O\nSlovenia B-LOC\n7.77 O\n\n43. O\nCroatia B-LOC\n7.75 O\n\n44. O\nBulgaria B-LOC\n7.73 O\n\n45. O\nMalta B-LOC\n7.40 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPOLICE O\nCOMMANDOS O\nON O\nHAND O\nFOR O\nAUSTRALIANS B-MISC\n' O\nFIRST O\nMATCH O\n. O\n\nCOLOMBO B-LOC\n1996-08-22 O\n\nArmed O\npolice O\ncommandos O\npatrolled O\nthe O\nground O\nwhen O\nAustralia B-LOC\nopened O\ntheir O\nshort O\ntour O\nof O\nSri B-LOC\nLanka I-LOC\nwith O\na O\nfive-run O\nwin O\nover O\nthe O\ncountry O\n's O\nyouth O\nteam O\non O\nThursday O\n. O\n\nAustralia B-LOC\n, O\nin O\nSri B-LOC\nLanka I-LOC\nfor O\na O\nlimited O\novers O\ntournament O\nwhich O\nalso O\nincludes O\nIndia B-LOC\nand O\nZimbabwe B-LOC\n, O\nhave O\nbeen O\npromised O\nthe O\npresence O\nof O\ncommandos O\n, O\nsniffer O\ndogs O\nand O\nplainclothes O\npolicemen O\nto O\nensure O\nthe O\ntournament O\nis O\ntrouble-free O\n. O\n\nThey O\nare O\nmaking O\ntheir O\nfirst O\nvisit O\nto O\nthe O\nisland O\nsince O\nboycotting O\na O\nWorld B-MISC\nCup I-MISC\nfixture O\nin O\nFebruary O\nbecause O\nof O\nfears O\nover O\nethnic O\nviolence O\n. O\n\nAustralia B-LOC\n, O\nbatting O\nfirst O\nin O\nThursday O\n's O\nthe O\nwarm-up O\nmatch O\n, O\nscored O\n251 O\nfor O\nseven O\nfrom O\ntheir O\n50 O\novers O\n. O\n\nRicky B-PER\nPonting I-PER\nled O\nthe O\nway O\nwith O\n100 O\noff O\n119 O\nballs O\nwith O\ntwo O\nsixes O\nand O\nnine O\nfours O\nbefore O\nretiring O\n. O\n\nThe O\nyouth O\nside O\nreplied O\nwith O\n246 O\nfor O\nseven O\n. O\n\nAustralian B-MISC\ncoach O\nGeoff B-PER\nMarsh I-PER\nsaid O\nhe O\nwas O\nimpressed O\nwith O\nthe O\ncompetitiveness O\nof O\nthe O\nopposition O\n. O\n\n\" O\nWe O\nwere O\nmade O\nto O\nsweat O\nto O\nwin O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nONE O\nROMANIAN B-MISC\nDIES O\nIN O\nBUS O\nCRASH O\nIN O\nBULGARIA B-LOC\n. O\n\nSOFIA B-LOC\n1996-08-22 O\n\nOne O\nRomanian B-MISC\npassenger O\nwas O\nkilled O\n, O\nand O\n14 O\nothers O\nwere O\ninjured O\non O\nThursday O\nwhen O\na O\nRomanian-registered B-MISC\nbus O\ncollided O\nwith O\na O\nBulgarian B-MISC\none O\nin O\nnorthern O\nBulgaria B-LOC\n, O\npolice O\nsaid O\n. O\n\nThe O\ntwo O\nbuses O\ncollided O\nhead O\non O\nat O\n5 O\no'clock O\nthis O\nmorning O\non O\nthe O\nroad O\nbetween O\nthe O\ntowns O\nof O\nRousse B-LOC\nand O\nVeliko B-LOC\nTarnovo I-LOC\n, O\npolice O\nsaid O\n. O\n\nA O\nRomanian B-MISC\nwoman O\nMaria B-PER\nMarco I-PER\n, O\n35 O\n, O\nwas O\nkilled O\n. O\n\nThe O\naccident O\nwas O\nbeing O\ninvestigated O\n, O\npolice O\nadded O\n. O\n\n-- O\nSofia B-ORG\nNewsroom I-ORG\n, O\n359-2-84561 O\n\n-DOCSTART- O\n\nOFFICIAL B-ORG\nJOURNAL I-ORG\nCONTENTS O\n- O\nOJ B-ORG\nL O\n211 O\nOF O\nAUGUST O\n21 O\n, O\n1996 O\n. O\n\n* O\n\n( O\nNote O\n- O\ncontents O\nare O\ndisplayed O\nin O\nreverse O\norder O\nto O\nthat O\nin O\nthe O\nprinted O\nJournal B-ORG\n) O\n\n* O\n\nCorrigendum O\nto O\nCommission B-MISC\nRegulation I-MISC\n( O\nEC B-ORG\n) O\nNo O\n1464/96 O\nof O\n25 O\nJuly O\n1996 O\nrelating O\nto O\na O\nstanding O\ninvitation O\nto O\ntender O\nto O\ndetermine O\nlevies O\nand O\n/ O\nor O\nrefunds O\non O\nexports O\nof O\nwhite O\nsugar O\n( O\nOJ O\nNo O\nL O\n187 O\nof O\n26.7.1996 O\n) O\n\nCorrigendum O\nto O\nCommission B-MISC\nRegulation I-MISC\n( O\nEC B-ORG\n) O\nNo O\n658/96 O\nof O\n9 O\nApril O\n1996 O\non O\ncertain O\nconditions O\nfor O\ngranting O\ncompensatory O\npayments O\nunder O\nthe O\nsupport O\nsystem O\nfor O\nproducers O\nof O\ncertain O\narable O\ncrops O\n( O\nOJ B-ORG\nNo O\nL O\n91 O\nof O\n12.4.1996 O\n) O\n\nCommission B-MISC\nRegulation I-MISC\n( O\nEC B-ORG\n) O\nNo O\n1663/96 O\nof O\n20 O\nAugust O\n1996 O\nestablishing O\nthe O\nstandard O\nimport O\nvalues O\nfor O\ndetermining O\nthe O\nentry O\nprice O\nof O\ncertain O\nfruit O\nand O\nvegetables O\nEND O\nOF O\nDOCUMENT O\n. O\n\n-DOCSTART- O\n\nIn B-ORG\nHome I-ORG\nHealth I-ORG\nto O\nappeal O\npayment O\ndenial O\n. O\n\nMINNETONKA B-LOC\n, O\nMinn B-LOC\n. O\n\n1996-08-22 O\n\nIn B-ORG\nHome I-ORG\nHealth I-ORG\nInc I-ORG\nsaid O\non O\nThursday O\nit O\nwill O\nappeal O\nto O\nthe O\nU.S. B-ORG\nFederal I-ORG\nDistrict I-ORG\nCourt I-ORG\nin O\nMinneapolis B-LOC\na O\ndecision O\nby O\nthe O\nHealth B-ORG\nCare I-ORG\nFinancing I-ORG\nAdministration I-ORG\n( O\nHCFA B-ORG\n) O\nthat O\ndenied O\nreimbursement O\nof O\ncertain O\ncosts O\nunder O\nMedicaid B-MISC\n. O\n\nThe O\nHCFA B-ORG\nAdministrator O\nreversed O\na O\npreviously O\nfavorable O\ndecision O\nregarding O\nthe O\nreimbursement O\nof O\ncosts O\nrelated O\nto O\nthe O\ncompany O\n's O\ncommunity O\nliaison O\npersonnel O\n, O\nit O\nadded O\n. O\n\nThe O\ncompany O\nsaid O\nit O\ncontinues O\nto O\nbelieve O\nthe O\nmajority O\nof O\nthe O\ncommunity O\nliaison O\ncosts O\nare O\ncoverable O\nunder O\nthe O\nterms O\nof O\nthe O\nMedicare B-MISC\nprogram O\n. O\n\n\" O\nWe O\nare O\ndisappointed O\nwith O\nthe O\nadministrator O\n's O\ndecision O\nbut O\nwe O\ncontinue O\nto O\nbe O\noptimistic O\nregarding O\nan O\nultimate O\nfavorable O\nresolution O\n, O\n\" O\nMark B-PER\nGildea I-PER\n, O\nchief O\nexecutive O\nofficer O\n, O\nsaid O\nin O\na O\nstatement O\n. O\n\nIn B-ORG\nHome I-ORG\nHealth I-ORG\nsaid O\nit O\npreviously O\nrecorded O\na O\nreserve O\nequal O\nto O\n16 O\npercent O\nof O\nall O\nrevenue O\nrelated O\nto O\nthe O\ncommunity O\nliaison O\ncosts O\n. O\n\nSeparately O\n, O\nIn B-ORG\nHome I-ORG\nHealth I-ORG\nsaid O\nthe O\nU.S. B-ORG\nDistrict I-ORG\nCourt I-ORG\nin O\nMinneapolis B-LOC\nruled O\nin O\nits O\nfavor O\nregarding O\nthe O\nreimbursement O\nof O\ncertain O\ninterest O\nexpenses O\n. O\n\nThis O\ndecision O\nwill O\nresult O\nin O\nthe O\nreimbursement O\nby O\nMedicare B-MISC\nof O\n$ O\n81,000 O\nin O\ndisputed O\ncosts O\n. O\n\n\" O\nThis O\nis O\nour O\nfirst O\ndecision O\nin O\nfederal O\ndistrct O\ncourt O\nregarding O\na O\ndispute O\nwith O\nMedicare B-MISC\n, O\n\" O\nGildea B-PER\nsaid O\n. O\n\" O\n\nWe O\nare O\nextremely O\npleased O\nwith O\nthis O\ndecision O\nand O\nwe O\nrecognize O\nit O\nas O\na O\nsignificant O\nstep O\ntoward O\nresolution O\nof O\nour O\noutstanding O\nMedicare B-MISC\ndisputes O\n. O\n\" O\n\n-- O\nChicago B-ORG\nNewsdesk I-ORG\n312-408-8787 O\n\n-DOCSTART- O\n\nOppenheimer B-ORG\nCapital I-ORG\nto O\nreview O\nOct. O\ndiv O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-22 O\n\nOppenheimer B-ORG\nCapital I-ORG\nLP I-ORG\nsaid O\non O\nThursday O\nit O\nwill O\nreview O\nits O\ncash O\ndistribution O\nrate O\nfor O\nthe O\nOctober O\nquarterly O\ndistribution O\n, O\nassuming O\ncontinued O\nfavorable O\nresults O\n. O\n\nThe O\ncompany O\n, O\nwhich O\nreported O\nimproved O\nfirst O\nquarter O\nearnings O\nfor O\nthe O\nperiod O\nended O\nJuly O\n31 O\n, O\n1996 O\n, O\ndeclared O\na O\nquarterly O\ndistribution O\nof O\n$ O\n0.65 O\nper O\npartnership O\nunit O\nfor O\nthe O\nquarter O\nended O\nJuly O\n. O\n\n-DOCSTART- O\n\nBest B-ORG\nsees O\nQ2 O\nloss O\nsimilar O\nto O\nQ1 O\nloss O\n. O\n\nRICHMOND B-LOC\n, O\nVa B-LOC\n. O\n\n1996-08-22 O\n\nBest B-ORG\nProducts I-ORG\nCo I-ORG\nChairman O\nand O\nChief O\nExecutive O\nDaniel B-PER\nLevy I-PER\nsaid O\nThursday O\nhe O\nexpected O\nthe O\ncompany O\n's O\nsecond-quarter O\nresults O\nto O\nbe O\nsimilar O\nto O\nthe O\n$ O\n34.6 O\nmillion O\nloss O\nposted O\nin O\nthe O\nfirst O\nquarter O\n. O\n\nHe O\nalso O\ntold O\nReuters B-ORG\nbefore O\nthe O\nretailer O\n's O\nannual O\nmeeting O\nthat O\nthe O\nsecond O\nquarter O\ncould O\nbe O\nbetter O\nthan O\nthe O\nfirst O\nquarter O\nended O\nMay O\n4 O\n. O\n\" O\n\nWe O\ncould O\ndo O\neven O\nbetter O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\nsecond-quarter O\nresults O\nare O\nexpected O\nto O\nbe O\nreleased O\nin O\nSeptember O\n. O\n\nLevy B-PER\nsaid O\nseeking O\nbankruptcy O\nprotection O\nwas O\nnot O\nunder O\nconsideration O\n. O\n\nBest B-ORG\nemerged O\nfrom O\nChapter B-MISC\n11 I-MISC\nbankruptcy O\nprotection O\nin O\nJune O\n1994 O\nafter O\n3-1/2 O\nyears O\n. O\n\n\" O\nBankruptcy O\nis O\nalways O\npossible O\n, O\nparticularly O\nwhen O\nyou O\nlose O\nwhat O\nwe O\nare O\ngoing O\nto O\nlose O\nin O\nthe O\nfirst O\nhalf O\nof O\nthis O\nyear O\n, O\n\" O\nLevy B-PER\nsaid O\n. O\n\" O\n\nBut O\nthis O\nis O\nnot O\nsomething O\nwe O\nare O\nstriving O\nto O\ndo O\n. O\n\" O\n\nThe O\nRichmond-based B-MISC\nretailer O\nlost O\n$ O\n95.7 O\nmillion O\nin O\nthe O\nfiscal O\nyear O\nended O\nFebruary O\n3 O\n. O\n\nThat O\nwas O\nthe O\nsecond-largest O\nloss O\nin O\nthe O\ncompany O\n's O\nhistory O\n. O\n\nLevy B-PER\nsaid O\nthat O\nBest B-ORG\nplanned O\nto O\nopen O\ntwo O\nnew O\nstores O\nthis O\nfall O\n. O\n\nThe O\ncompany O\nannounced O\nin O\nMarch O\nthat O\nit O\nwas O\nclosing O\nseven O\nstores O\nand O\nbacking O\nout O\nof O\nnine O\nnew O\nlease O\nagreements O\n. O\n\nAt O\nthe O\ntime O\n, O\nBest B-ORG\nsaid O\nit O\ndid O\nnot O\nplan O\nto O\nopen O\nany O\nnew O\nstores O\nthis O\nfall O\n. O\n\nIt O\ncurrently O\noperates O\n169 O\nstores O\nin O\n23 O\nstates O\n. O\n\nFor O\nlast O\nyear O\n's O\nsecond O\nquarter O\n, O\nwhich O\nended O\nJuly O\n29 O\n, O\n1995 O\n, O\nBest B-ORG\nposted O\na O\nloss O\nof O\n$ O\n7.1 O\nmillion O\n, O\nor O\n$ O\n0.23 O\nper O\nshare O\n, O\non O\nsales O\nof O\n$ O\n311.9 O\nmillion O\n. O\n\n-DOCSTART- O\n\nMeasles O\nexposure O\ncan O\nlead O\nto O\nbowel O\ndisease O\n- O\nstudy O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nWomen O\nwho O\nget O\nmeasles O\nwhile O\npregnant O\nmay O\nhave O\nbabies O\nat O\nhigher O\nrisk O\nof O\nCrohn B-PER\n's O\ndisease O\n, O\na O\ndebilitating O\nbowel O\ndisorder O\n, O\nresearchers O\nsaid O\non O\nFriday O\n. O\n\nThree O\nout O\nof O\nfour O\nSwedish B-MISC\nbabies O\nborn O\nto O\nmothers O\nwho O\ncaught O\nmeasles O\ndeveloped O\nserious O\ncases O\nof O\nCrohn B-PER\n's O\ndisease O\n, O\nthe O\nresearchers O\nsaid O\n. O\n\nDr O\nAndrew B-PER\nWakefield I-PER\nof O\nthe O\nRoyal B-LOC\nFree I-LOC\nHospital I-LOC\nSchool I-LOC\nof I-LOC\nMedicine I-LOC\nand O\ncolleagues O\nscreened O\n25,000 O\nbabies O\ndelivered O\nat O\nUniversity B-LOC\nHospital I-LOC\n, O\nUppsala B-LOC\n, O\nbetween O\n1940 O\nand O\n1949 O\n. O\n\nFour O\nof O\nthe O\nmothers O\nhad O\nmeasles O\nwhile O\npregnant O\n. O\n\n\" O\nThree O\nof O\nthe O\nfour O\nchildren O\nhad O\nCrohn B-PER\n's O\ndisease O\n, O\n\" O\nWakefield B-PER\n's O\ngroup O\nwrote O\nin O\nthe O\nLancet B-ORG\nmedical O\njournal O\n. O\n\nCrohn B-PER\n's O\nis O\nan O\ninflammation O\nof O\nthe O\nbowel O\nthat O\ncan O\nsometimes O\nrequire O\nsurgery O\n. O\n\nIt O\ncauses O\ndiarrhoea O\n, O\nabdominal O\npain O\nand O\nweight O\nloss O\n. O\n\nThe O\nresearchers O\nsaid O\nthe O\nthree O\nchildren O\ninvolved O\nhad O\nespecially O\nsevere O\ncases O\n. O\n\nExposure O\nto O\nviruses O\ncan O\noften O\ncause O\nbirth O\ndefects O\n. O\n\nMost O\nnotably O\n, O\nwomen O\nwho O\nget O\nrubella O\n( O\nGerman B-MISC\nmeasles O\n) O\nhave O\na O\nhigh O\nrisk O\nof O\na O\nstillborn O\nbaby O\n. O\n\n-DOCSTART- O\n\nAll O\nthe O\nkey O\nnumbers O\n- O\nCBI B-ORG\nAugust O\nindustrial O\ntrends O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nFollowing O\nare O\nkey O\ndata O\nfrom O\nthe O\nAugust O\nmonthly O\nsurvey O\nof O\ntrends O\nin O\nUK B-LOC\nmanufacturing O\nby O\nthe O\nConfederation B-ORG\nof I-ORG\nBritish I-ORG\nIndustry I-ORG\n( O\nCBI B-ORG\n) O\n. O\n\nCBI B-ORG\nMONTHLY O\nTRENDS O\nENQUIRY O\n( O\na O\n) O\nAUG O\nJULY O\nJUNE O\nMAY O\n\n- O\ntotal O\norder O\nbook O\n- O\n10 O\n- O\n22 O\n- O\n13 O\n- O\n17 O\n\n- O\nexport O\norder O\nbook O\n- O\n14 O\n- O\n13 O\n- O\n11 O\n- O\n7 O\n\n- O\nstocks O\nof O\nfinished O\ngoods O\n+17 O\n+19 O\n+17 O\n+25 O\n\n- O\noutput O\nexpectations O\n* O\n+22 O\n+22 O\n+12 O\n+16 O\n\n- O\ndomestic O\nprice O\nexpectations O\n* O\n0 O\n- O\n1 O\n+6 O\n+4 O\n\nNOTES O\n- O\n* O\nover O\nthe O\ncoming O\nfour O\nmonths O\n; O\n\n- O\n( O\na O\n) O\nin O\npercent O\n, O\ngiving O\nbalance O\nbetween O\nthose O\n\nreplying O\n\" O\nabove O\nnormal O\n\" O\nand O\nthose O\nreplying O\n\" O\nbelow O\nnormal O\n. O\n\" O\n\nThe O\nsurvey O\nwas O\nconducted O\nbetween O\nJuly O\n23 O\nand O\nAugust O\n14 O\nand O\ninvolved O\n1,305 O\ncompanies O\n, O\nrepresenting O\n50 O\nindustries O\n, O\naccounting O\nfor O\naround O\nhalf O\nof O\nthe O\nUK B-LOC\n's O\nmanufactured O\nexports O\nand O\nsome O\ntwo O\nmillion O\nemployees O\n. O\n\n-- O\nRosemary B-PER\nBennett I-PER\n, O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n7715 O\n\n-DOCSTART- O\n\nLondon B-LOC\nshipsales O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\n- O\nSecondhand O\ntonnage O\nbrokers O\nreported O\nthe O\nsale O\nof O\nthe O\nfollowing O\nvessels O\n. O\n\nIron B-MISC\nGippsland I-MISC\n- O\n( O\nbuilt O\n1989 O\n) O\n87,241 O\ndwt O\nsold O\nto O\nGreek B-MISC\nbuyers O\nfor O\n$ O\n30 O\nmillion O\n. O\n\nSairyu B-MISC\nMaru I-MISC\nNo I-MISC\n: I-MISC\n2 I-MISC\n- O\n( O\nbuilt O\n1982 O\n) O\n60,960 O\ndwt O\nsold O\nto O\nGreek B-MISC\nbuyers O\nfor O\n$ O\n15.5 O\nmillion O\n. O\n\nStainless B-MISC\nFighter I-MISC\n- O\n( O\nbuilt O\n1970 O\n) O\n21,718 O\ndwt O\nsold O\nat O\nauction O\nfor O\n$ O\n6 O\nmillion O\n. O\n\nSome O\nof O\nthese O\nsales O\nmay O\nnot O\nbe O\nfinal O\nas O\nthey O\nmay O\nbe O\nsubject O\nto O\ninspection O\n, O\nsurvey O\nor O\nother O\nconditions O\n. O\n\n-DOCSTART- O\n\nGarlic O\npills O\ndo O\nn't O\nlower O\ncholesterol O\n, O\nstudy O\nfinds O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nGarlic O\npills O\nmay O\nnot O\nlower O\nblood O\ncholesterol O\nand O\nstudies O\nthat O\nshow O\nthey O\ndo O\nmay O\nbe O\nflawed O\n, O\nBritish B-MISC\nresearchers O\nhave O\nreported O\n. O\n\nA O\nstudy O\nby O\na O\nteam O\nof O\ndoctors O\nat O\nOxford B-ORG\nUniversity I-ORG\nhas O\nfound O\npeople O\nwith O\nhigh O\nblood O\ncholesterol O\ndo O\nnot O\nbenefit O\nsignificantly O\nfrom O\ntaking O\ngarlic O\ntablets O\n. O\n\nThe O\nstudy O\ninvolved O\n115 O\npeople O\nwith O\nhigh O\nblood O\ncholesterol O\nlevels O\n. O\n\nThey O\nwere O\ngiven O\n900 O\nmilligrams O\na O\nday O\nof O\ndried O\ngarlic O\npowder O\nor O\nplacebo O\ntablets O\n. O\n\" O\n\nThere O\nwere O\nno O\nsignificant O\ndifferences O\nbetween O\nthe O\ngroups O\nreceiving O\ngarlic O\nand O\nplacebo O\n, O\n\" O\nthey O\nwrote O\nin O\nthe O\nJournal B-ORG\nof I-ORG\nthe I-ORG\nRoyal I-ORG\nCollege I-ORG\nof I-ORG\nPhysicians I-ORG\n. O\n\nThose O\ntaking O\npart O\nwere O\ntold O\nto O\neat O\na O\nlow-fat O\ndiet O\nfor O\nsix O\nweeks O\nbefore O\nthey O\nstarted O\ntaking O\nthe O\npills O\n, O\nand O\ntheir O\nblood O\ncholesterol O\nmeasured O\nbefore O\nand O\nafter O\nthe O\nsix-week O\nperiod O\n. O\n\nThe O\nresearchers O\nsaid O\nthis O\nwould O\nmake O\ntheir O\nfindings O\nmore O\naccurate O\n. O\n\nSeveral O\nstudies O\nhave O\nfound O\ngarlic O\npills O\ncan O\nlower O\nblood O\npressure O\nand O\nblood O\ncholesterol O\n. O\n\nBut O\nthe O\nOxford B-LOC\nteam O\ndisputed O\nthese O\nfindings O\nand O\nsaid O\neither O\nprevious O\ntrials O\nmay O\nhave O\nbeen O\ninterpreted O\nincorrectly O\n, O\nthose O\ntaking O\npart O\nwere O\nnot O\ngiven O\nspecial O\ndiets O\nbeforehand O\nor O\nthe O\nduration O\nof O\nthe O\nstudies O\nmay O\nhave O\nbeen O\ntoo O\nshort O\n. O\n\nThe O\nsix-month O\ntrial O\nwas O\nfunded O\nby O\nthe O\nBritish B-ORG\nHeart I-ORG\nFoundation I-ORG\nand O\nLichtwer B-ORG\nPharma I-ORG\nGmbH I-ORG\n, O\nwhich O\nmakes O\nKwai B-MISC\nbrand O\ngarlic O\ntablets O\n. O\n\nThe O\nstudy O\ndid O\nnot O\naddress O\nwhether O\nwhole O\ngarlic O\ncould O\naffect O\ncholesterol O\n. O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n7950 O\n\n-DOCSTART- O\n\nBritain B-LOC\ngives O\naid O\nto O\nvolcano-hit O\nCaribbean B-LOC\nisland O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nBritain B-LOC\nsaid O\non O\nThursday O\nit O\nwould O\ngive O\n25 O\nmillion O\npounds O\n( O\n$ O\n39 O\nmillion O\n) O\nof O\ndevelopment O\naid O\nto O\nthe O\nCaribbean B-LOC\nisland O\nof O\nMontserrat B-LOC\n, O\nwhere O\nmuch O\nof O\nthe O\npopulation O\nliving O\nin O\nthe O\nsouth O\nhas O\nfled O\nto O\navoid O\na O\nvolcano O\n. O\n\nThe O\nvolcano O\nin O\nthe O\nSoufriere O\nhills O\nhas O\nerupted O\nthree O\ntimes O\nin O\nthe O\npast O\n13 O\nmonths O\nand O\nlast O\nApril O\nsome O\n4,500 O\npeople O\nliving O\nin O\nthe O\ncapital O\n, O\nPlymouth B-ORG\n, O\nand O\nsouthern O\nareas O\nwere O\nevacuated O\nto O\nthe O\nnorth O\n, O\nwhere O\nmany O\nare O\nliving O\nin O\npublic O\nshelters O\nand O\nschools O\n. O\n\n\" O\nThis O\nassistance O\nwill O\nprovide O\na O\nfast O\ntrack O\ndevelopment O\nprogramme O\nfor O\nthe O\ndesignated O\n( O\nnorthern O\n) O\nsafe O\narea O\n, O\n\" O\nBritain B-LOC\n's O\nOverseas B-ORG\nDevelopment I-ORG\nAdministration I-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\nBritain B-LOC\ngave O\n8.5 O\nmillion O\npounds O\n( O\n$ O\n13 O\nmillion O\n) O\nto O\nMontserrat B-LOC\n, O\nwhich O\nis O\none O\nof O\nits O\ndependent O\nterritories O\n, O\nwhen O\nthe O\nvolcano O\nfirst O\nbecame O\nactive O\n. O\n\nOverseas O\nDevelopment O\nMinister O\nLynda B-PER\nChalker I-PER\nsaid O\na O\nrecent O\ncensus O\nhad O\nshown O\nmost O\nMontserratians B-MISC\nwanted O\nto O\nremain O\non O\nthe O\nisland O\n. O\n\" O\n\nThe O\ndevelopment O\nof O\nthe O\nnorth O\nwill O\nhelp O\nthem O\nto O\ndo O\njust O\nthat O\n, O\n\" O\nshe O\nsaid O\n. O\n\n-DOCSTART- O\n\nTennis O\n- O\nPhilippoussis B-PER\nlooms O\nfor O\nSampras B-PER\nin O\nU.S. B-MISC\nOpen I-MISC\n. O\n\nBill B-PER\nBerkrot I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-22 O\n\nWorld O\nnumber O\none O\nPete B-PER\nSampras I-PER\n, O\nseeking O\nhis O\nfirst O\nGrand B-MISC\nSlam I-MISC\ntitle O\nof O\nthe O\nyear O\n, O\nand O\nwomen O\n's O\ntop O\nseed O\nSteffi B-PER\nGraf I-PER\n, O\naiming O\nfor O\nher O\nthird O\n, O\nshould O\nbe O\nable O\nto O\nease O\ninto O\nthe O\nyear O\n's O\nfinal O\nmajor O\n, O\nwhich O\nbegins O\non O\nMonday O\n. O\n\nSampras B-PER\nopens O\nthe O\ndefence O\nof O\nhis O\nU.S. B-MISC\nOpen I-MISC\ncrown O\nagainst O\nDavid B-PER\nRikl I-PER\nof O\nthe O\nCzech B-LOC\nRepublic I-LOC\n, O\nwhile O\ntop-ranked O\nGraf B-PER\nbegins O\nher O\ntitle O\ndefence O\nagainst O\nYayuk B-PER\nBasuki I-PER\nof O\nIndonesia B-LOC\n. O\n\nWednesday O\n's O\nU.S. B-MISC\nOpen I-MISC\ndraw O\nceremony O\nrevealed O\nthat O\nboth O\ntitle O\nholders O\nshould O\nrun O\ninto O\ntheir O\nfirst O\nserious O\nopposition O\nin O\nthe O\nthird O\nround O\n. O\n\nLooming O\nin O\nSampras B-PER\n's O\nfuture O\nis O\na O\nlikely O\nthird-round O\ndate O\nwith O\nrecent O\nnemesis O\nMark B-PER\nPhilippoussis I-PER\n, O\nthe O\nrising O\nAustralian B-MISC\nwho O\ntook O\nout O\nSampras B-PER\nin O\nthe O\nthird O\nround O\nof O\nthe O\nAustralian B-MISC\nOpen I-MISC\nin O\nJanuary O\n. O\n\nSampras B-PER\navenged O\nthat O\ndefeat O\nwith O\na O\nstraight O\nsets O\nwin O\nover O\nthe O\n19-year-old O\npower O\nhitter O\nin O\nthe O\nsecond O\nround O\nat O\nWimbledon B-LOC\nand O\ntheir O\nrubber O\nmatch O\nin O\nNew B-LOC\nYork I-LOC\ncould O\nprovide O\nsome O\nfirst-week O\nfireworks O\n. O\n\nWhile O\nonly O\na O\nstunning O\nupset O\nwill O\nkeep O\nGraf B-PER\nfrom O\nsailing O\nthrough O\nto O\na O\npredictable O\nsemifinal O\nshowdown O\nwith O\nthird O\nseed O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\n, O\nthe O\nGerman B-MISC\nstar O\ncould O\nalso O\nbe O\ntested O\nin O\nthe O\nthird O\nround O\nwhere O\nshe O\nwill O\nprobably O\nface O\n28th-ranked O\nveteran O\nNatasha B-PER\nZvereva I-PER\nof O\nBelarus B-LOC\n. O\n\nThere O\nwill O\nbe O\nno O\nrepeat O\nof O\nlast O\nyear O\n's O\nmen O\n's O\nfinal O\nwith O\neighth-ranked O\nAndre B-PER\nAgassi I-PER\nlanding O\nin O\nSampras B-PER\n's O\nhalf O\nof O\nthe O\ndraw O\n. O\n\nBumping O\nAgassi B-PER\nup O\nto O\nthe O\nsixth O\nseeding O\navoided O\nthe O\npossibility O\nthat O\nhe O\nwould O\nrun O\ninto O\nSampras B-PER\nas O\nearly O\nas O\nthe O\nquarter-finals O\n, O\nbut O\nthey O\ncould O\nlock O\nhorns O\nin O\nthe O\nsemis O\n. O\n\nOlympic B-MISC\nchampion O\nAgassi B-PER\nmeets O\nKarim B-PER\nAlami I-PER\nof O\nMorocco B-LOC\nin O\nthe O\nfirst O\nround O\n. O\n\nSurprise O\nsecond O\nseed O\nMichael B-PER\nChang I-PER\n, O\nranked O\nthird O\nin O\nthe O\nworld O\n, O\nopens O\nagainst O\nCzech B-MISC\nDaniel B-PER\nVacek I-PER\n, O\nwhile O\nwomen O\n's O\nsecond O\nseed O\nMonica B-PER\nSeles I-PER\ndrew O\nAmerican B-MISC\nAnne B-PER\nMiller I-PER\nas O\nher O\nfirst O\nvictim O\n. O\n\nSecond-ranked O\nAustrian B-MISC\nThomas B-PER\nMuster I-PER\n, O\nwho O\nwas O\nseeded O\nthird O\n, O\ndid O\nnot O\nhave O\nthe O\nluck O\nof O\nthe O\ndraw O\nwith O\nhim O\n. O\n\nIn O\nthe O\nfirst O\nround O\nMuster B-PER\nfaces O\nAmerican B-MISC\nRichey B-PER\nReneberg I-PER\n, O\nwho O\nhas O\nbeen O\nplaying O\nsome O\nof O\nthe O\nbest O\ntennis O\nof O\nhis O\ncareer O\nof O\nlate O\n. O\n\nIf O\nhe O\nsurvives O\n, O\nMuster B-PER\nis O\nseeded O\nto O\nrun O\ninto O\neither O\nfifth-seeded O\nWimbledon B-MISC\nchampion O\nRichard B-PER\nKrajicek I-PER\nof O\nthe O\nNetherlands B-LOC\nor O\n12th-seeded O\nAmerican B-MISC\nTodd B-PER\nMartin I-PER\nin O\nthe O\nquarter-finals O\nin O\nChang B-PER\n's O\nhalf O\nof O\nthe O\ndraw O\n. O\n\nPerhaps O\nthe O\nbest O\n, O\nyet O\nmost O\nunfortunate O\n, O\nfirst-round O\nmatchup O\nof O\nthe O\nmen O\n's O\ncompetition O\npits O\neighth O\nseed O\nJim B-PER\nCourier I-PER\nagainst O\nretiring O\nstar O\nStefan B-PER\nEdberg I-PER\n. O\n\nThe O\npopular O\nSwede B-MISC\nis O\nplaying O\nhis O\nfinal O\nmajor O\ntournament O\nnext O\nweek O\nand O\nthe O\ntwo-time O\nchampion O\n's O\nGrand B-MISC\nSlam I-MISC\nfarewell O\ncould O\nwell O\nbe O\na O\none-match O\naffair O\n. O\n\nWith O\nthe O\nexception O\nof O\na O\nPhilippoussis B-PER\nshowdown O\n, O\nSampras B-PER\nlooks O\nto O\nhave O\nlanded O\nin O\na O\ncomfortable O\nquarter O\nof O\nthe O\ndraw O\nwith O\nthe O\nlikes O\nof O\nFrenchman B-MISC\nCedric B-PER\nPioline I-PER\nand O\nailing O\nFrench B-MISC\nOpen I-MISC\nchampion O\nYevgeny B-PER\nKafelnikov I-PER\n, O\nwho O\nis O\nnursing O\na O\nrib O\ninjury O\n, O\nin O\nhis O\npath O\n. O\n\nSeles B-PER\n, O\nrunner-up O\nto O\nGraf B-PER\nlast O\nyear O\n, O\nis O\nseeded O\nto O\nrun O\ninto O\nfifth-ranked O\nGerman B-MISC\nAnke B-PER\nHuber I-PER\nin O\nthe O\nquarter-finals O\nwith O\nfourth O\nseed O\nConchita B-PER\nMartinez I-PER\nor O\neighth-seeded O\nOlympic B-MISC\nchampion O\nLindsay B-PER\nDavenport I-PER\nlooking O\nlike O\nher O\nmost O\nlikely O\nsemifinal O\nopponents O\n. O\n\nBut O\nHuber B-PER\nwill O\nbe O\ntested O\nimmediately O\nwith O\na O\nfirst-round O\nencounter O\nagainst O\ndangerous O\n18th-ranked O\nSouth B-MISC\nAfrican I-MISC\nAmanda B-PER\nCoetzer I-PER\n. O\n\nSanchez B-PER\nVicario I-PER\n, O\nrunner-up O\nto O\nGraf B-PER\nat O\nthe O\nFrench B-MISC\nOpen I-MISC\nand O\nWimbledon B-MISC\n, O\nbegins O\nplay O\nagainst O\na O\nqualifier O\nin O\na O\nquarter O\nof O\nthe O\ndraw O\nthat O\nincludes O\nyoung O\ntalent O\nMartina B-PER\nHingis I-PER\n, O\nthe O\n16th O\nseed O\n, O\nbefore O\na O\nprobable O\nquarter-final O\nclash O\nwith O\nseventh-seeded O\nveteran O\nJana B-PER\nNovotna I-PER\n. O\n\nMartinez B-PER\nbegins O\nplay O\nagainst O\nRuxandra B-PER\nDragomir I-PER\nof O\nRomania B-LOC\n. O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373-1800 O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nTennis O\n- O\nMuster B-PER\nupset O\n, O\nPhilippoussis B-PER\nwins O\n, O\nStoltenberg B-PER\nloses O\n. O\n\nTORONTO B-LOC\n1996-08-21 O\n\nTop-seeded O\nThomas B-PER\nMuster I-PER\nof O\nAustria B-LOC\nwas O\nbeaten O\n6-3 O\n7-5 O\nby O\n123rd-ranked O\nDaniel B-PER\nNestor I-PER\nof O\nCanada B-LOC\non O\nWednesday O\nin O\nhis O\nfirst O\nmatch O\nof O\nthe O\n$ O\n2 O\nmillion O\nCanadian B-MISC\nOpen I-MISC\n. O\n\nA O\nlefthander O\nwith O\na O\nstrong O\nserve O\n, O\nNestor B-PER\nkept O\nthe O\nrallies O\nshort O\nby O\nconstantly O\nattacking O\nthe O\nnet O\nand O\nthe O\ntactic O\nworked O\nin O\nthe O\nsecond-round O\nmatch O\nagainst O\nMuster B-PER\n, O\nplaying O\nhis O\nfirst O\nmatch O\nafter O\nreceiving O\na O\nfirst-round O\nbye O\nalong O\nwith O\nthe O\nother O\ntop O\neight O\nseeds O\n. O\n\nThe O\ntournament O\nalso O\nlost O\nits O\nsecond O\nseed O\non O\nthe O\nthird O\nday O\nof O\nplay O\nwhen O\nsecond-seeded O\nGoran B-PER\nIvanisevic I-PER\nof O\nCroatia B-LOC\nwas O\nbeaten O\n6-7(3-7 O\n) O\n6-4 O\n6-4 O\nby O\nunseeded O\nMikael B-PER\nTillstrom I-PER\nof O\nSweden B-LOC\n. O\n\nOther O\nseeded O\nplayers O\nadvancing O\nwere O\nnumber O\nthree O\nWayne B-PER\nFerreira I-PER\nof O\nSouth B-LOC\nAfrica I-LOC\n, O\nnumber O\nfour O\nMarcelo B-PER\nRios I-PER\nof O\nChile B-LOC\n, O\nnumber O\nsix O\nMaliVai B-PER\nWashington I-PER\nof O\nthe O\nUnited B-LOC\nStates I-LOC\nand O\nAmerican B-MISC\nTodd B-PER\nMartin I-PER\n, O\nthe O\nseventh O\nseeed O\n. O\n\nEighth O\nseed O\nMarc B-PER\nRosset I-PER\nof O\nSwitzerland B-LOC\nwas O\neliminated O\nin O\na O\none O\nhour O\n, O\n55 O\nminute O\nbattle O\nby O\nunseeded O\nMark B-PER\nPhilippoussis I-PER\nof O\nAustralia B-LOC\n. O\n\nPhilippoussis B-PER\nsaved O\na O\nmatch O\npoint O\nat O\n5-6 O\nin O\nthe O\nthird-set O\ntie O\nbreak O\nbefore O\nwinning O\n6-3 O\n3-6 O\n7-6 O\n( O\n8-6 O\n) O\n. O\n\nPhilippoussis B-PER\n's O\ncompatriot O\n, O\n13th O\nseed O\nJason B-PER\nStoltenberg I-PER\n, O\nwas O\nnot O\nas O\nfortunate O\n. O\n\nHe O\nheld O\none O\nmatch O\npoint O\nat O\n9-8 O\nin O\na O\nmarathon O\nthird-set O\ntie O\nbreak O\nbut O\nwas O\nbeaten O\n5-7 O\n7-6 O\n( O\n7-1 O\n) O\n7-6 O\n( O\n13-11 O\n) O\nby O\nunseeded O\nDaniel B-PER\nVacek I-PER\nof O\nthe O\nCzech B-LOC\nRepublic I-LOC\n. O\n\n\" O\nI O\nknew O\nI O\nhad O\nto O\nserve O\nwell O\nand O\nkeep O\nthe O\npoints O\nshort O\nand O\nthat O\n's O\nwhat O\nI O\nwas O\nable O\nto O\ndo O\n, O\n\" O\nsaid O\nNestor B-PER\n, O\nwho O\nranks O\n10th O\nin O\ndoubles O\n. O\n\nThere O\nwere O\nonly O\ntwo O\nservice O\nbreaks O\nin O\nthe O\nmatch O\n. O\n\nThe O\nlanky O\nCanadian B-MISC\nbroke O\nMuster B-PER\nat O\n4-3 O\nin O\nthe O\nfirst O\nset O\nand O\n5-5 O\nin O\nthe O\nsecond O\nbefore O\nending O\nthe O\nmatch O\non O\nhis O\nthird O\nmatch O\npoint O\nwhen O\nthe O\nAustrian B-MISC\nhit O\na O\nservice O\nreturn O\nlong O\n. O\n\n\" O\nI O\nprobably O\ndid O\nn't O\nhit O\nfive O\nground O\nstrokes O\nin O\nthe O\nwhole O\nmatch O\n, O\n\" O\nsaid O\nMuster B-PER\n, O\nonly O\npartly O\njoking O\n. O\n\" O\n\nThe O\nway O\nhe O\nwas O\nchipping O\nand O\ncharging O\nand O\nserving O\nand O\nvolleying O\nI O\ndid O\nn't O\nreally O\nget O\nmy O\ntiming O\nplaying O\nfrom O\nthe O\nbaseline O\n. O\n\" O\n\n\" O\nHe O\nplayed O\na O\ngood O\nmatch O\n, O\ntook O\na O\nfew O\nchances O\n, O\nand O\nevery O\ntime O\nhe O\nwas O\ndown O\nhe O\nwas O\nable O\nto O\ncome O\nup O\nwith O\na O\nbig O\nfirst O\nserve O\n. O\n\" O\n\nPlaying O\nat O\nnight O\nwas O\nnot O\nMuster B-PER\n's O\npreference O\n. O\n\" O\n\nI O\nasked O\nfor O\na O\nday O\nmatch O\nand O\nthey O\ngave O\nme O\na O\nnight O\nmatch O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nI O\ndo O\nn't O\nlike O\nplaying O\nunder O\nthe O\nlights O\nbut O\nmaybe O\nit O\nwould O\nnot O\nhave O\nmade O\nany O\ndifference O\n. O\n\" O\n\nIvanisevic B-PER\nrallied O\nfrom O\na O\n2-5 O\ndeficit O\nin O\nthe O\nfirst O\nset O\nbut O\nthen O\nplayed O\nerratically O\nagainst O\nthe O\n44th-ranked O\nTillstrom B-PER\n, O\nwho O\nwas O\na O\nsurprise O\nwinner O\nover O\nhis O\nfamous O\ncompatriot O\nStefan B-PER\nEdberg I-PER\nin O\nthe O\nsecond O\nround O\nat O\nWimbledon B-LOC\n. O\n\nIvanisevic B-PER\nhit O\n32 O\naces O\nbut O\nwas O\noutplayed O\nfrom O\nthe O\nback O\ncourt O\nby O\nthe O\n24-year-old O\nTillstrom B-PER\n. O\n\nThe O\nsixth-ranked O\nIvanisevic B-PER\n, O\nwho O\nlost O\nin O\nthe O\nfinal O\nat O\nIndianapolis B-LOC\nto O\nworld O\nnumber O\none O\nPete B-PER\nSampras I-PER\nof O\nthe O\nU.S. B-LOC\nlast O\nSunday O\n, O\nmade O\na O\nquick O\ngetaway O\nafter O\nhis O\nloss O\nbut O\ndid O\nsay O\n: O\n\" O\nSomething O\nwas O\nnot O\nthere O\nwhen O\nI O\narrived O\n( O\nin O\nToronto B-LOC\n) O\n. O\n\nI O\ndid O\nn't O\nfeel O\ngood O\n. O\n\nAnd O\nI O\ndid O\nn't O\nhave O\na O\ngood O\nfeeling O\nas O\nsoon O\nas O\nI O\nlost O\nin O\nmy O\ndoubles O\n( O\non O\nTuesday O\n) O\n. O\n\" O\n\n\" O\nI O\nthought O\nhe O\nlooked O\na O\nlittle O\nunfocused O\nat O\ncertain O\ntimes O\non O\nhis O\nground O\nstrokes O\n, O\n\" O\nsaid O\nTillstrom B-PER\n. O\n\nThe O\n19-year-old O\nPhilippoussis B-PER\n, O\nwho O\nbeat O\nSampras B-PER\nin O\nthe O\nthird O\nround O\nof O\nthis O\nyear O\n's O\nAustralian B-MISC\nOpen I-MISC\n, O\nstayed O\ncalm O\nin O\na O\nnervy O\nthird-set O\ntie O\nbreak O\nagainst O\nRosset B-PER\n. O\n\n\" O\nI O\n'm O\npleased O\nbecause O\nI O\ndid O\nn't O\nplay O\nthat O\ngreat O\ntoday O\n, O\nbut O\nI O\nfought O\nreally O\nwell O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nWhen O\nI O\nwas O\ndown O\n2-5 O\nin O\nthe O\ntiebreak O\n( O\nin O\nthe O\nthird O\nset O\n) O\n, O\nI O\njust O\nthought O\nabout O\nwinning O\nmy O\ntwo O\nserves O\nand O\nhoped O\nthat O\nhe O\nmight O\nget O\ntight O\n. O\n\nThen O\nhe O\nshanked O\na O\nforehand O\nat O\nto O\nmake O\nit O\n5-all O\nand O\nthat O\nhelped O\nme O\nback O\n. O\n\" O\n\n-DOCSTART- O\n\nSoccer O\n- O\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\npro-soccer O\ngames O\n. O\n\nSEOUL B-LOC\n1996-08-22 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\npro-soccer O\ngames O\nplayed O\non O\nWednesday O\n. O\n\nAnyang B-ORG\n3 O\nChonnam B-ORG\n3 O\n( O\nhalftime O\n2-0 O\n) O\n\nPuchon B-ORG\n0 O\nSuwon B-ORG\n0 O\n( O\nhalftime O\n0-0 O\n) O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nWednesday O\n( O\ntabulate O\nunder O\n- O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nW O\nD O\nL O\nG O\n/ O\nF O\nG O\n/ O\nA O\nP O\n\nPuchon B-ORG\n1 O\n1 O\n0 O\n1 O\n0 O\n4 O\n\nChonan B-ORG\n1 O\n0 O\n0 O\n5 O\n4 O\n3 O\n\nAnyang B-ORG\n0 O\n2 O\n0 O\n5 O\n5 O\n2 O\n\nSuwon B-ORG\n0 O\n2 O\n0 O\n3 O\n3 O\n2 O\n\nPohang B-ORG\n0 O\n1 O\n0 O\n3 O\n3 O\n1 O\n\nPusan B-ORG\n0 O\n1 O\n0 O\n0 O\n2 O\n1 O\n\nChonnam B-ORG\n0 O\n1 O\n1 O\n5 O\n6 O\n1 O\n\nUlsan B-ORG\n0 O\n0 O\n1 O\n4 O\n5 O\n0 O\n\nChonbuk B-ORG\n0 O\n0 O\n0 O\n0 O\n0 O\n0 O\n\n-DOCSTART- O\n\nSenegal B-LOC\ncholera O\noutbreak O\nkills O\nfive O\n. O\n\nDAKAR B-LOC\n1996-08-22 O\n\nAn O\noutbreak O\nof O\ncholera O\nhas O\nkilled O\nfive O\npeople O\nin O\nthe O\ncentral O\nSenegal B-LOC\ntown O\nof O\nKaolack B-LOC\n, O\nwhere O\nhealth O\nauthorities O\nhave O\nrecorded O\n291 O\ncases O\nsince O\nAugust O\n11 O\n, O\na O\nmedical O\nofficial O\nsaid O\non O\nThursday O\n. O\n\nDoctor O\nMasserigne B-PER\nNdiaye I-PER\nsaid O\nmedical O\nstaff O\nwere O\noverwhelmed O\nwith O\nwork O\n. O\n\" O\n\nPeople O\nare O\nrushing O\nto O\nthe O\nhospital O\nas O\nsoon O\nas O\nthe O\nfirst O\nsymptoms O\nappear O\n, O\nthat O\n's O\nwhy O\nwe O\nhave O\nfewer O\ndeaths O\n, O\n\" O\nhe O\ntold O\nReuters B-ORG\nby O\ntelephone O\nfrom O\nthe O\ntown O\n, O\n160 O\nkm O\n( O\n100 O\nmiles O\n) O\nsoutheast O\nof O\nthe O\nSenegalese B-MISC\ncapital O\nDakar B-LOC\n. O\n\n-DOCSTART- O\n\nNigerian B-MISC\ngeneral O\ntakes O\nover O\nLiberia B-LOC\nECOMOG B-ORG\nforce O\n. O\n\nMONROVIA B-LOC\n1996-08-22 O\n\nNigerian B-MISC\nMajor O\nGeneral O\nSam B-PER\nVictor I-PER\nMalu I-PER\ntook O\nover O\non O\nThursday O\nas O\ncommander O\nof O\nthe O\nECOMOG B-ORG\npeacekeeping O\nforce O\nin O\nLiberia B-LOC\n, O\ntwo O\ndays O\nafter O\nthe O\nstart O\nof O\nthe O\nlatest O\nceasefire O\nin O\nthe O\nsix-year O\ncivil O\nwar O\n. O\n\nMalu B-PER\nreplaced O\nanother O\nNigerian B-MISC\nmajor O\ngeneral O\n, O\nJohn B-PER\nInienger I-PER\n, O\nwho O\ntold O\nofficers O\nat O\nthe O\nhandover O\nceremony O\nthat O\npeace O\nwas O\nnow O\nat O\nhand O\nfor O\nLiberia B-LOC\nafter O\nsix O\nyears O\nof O\nfighting O\nand O\nmore O\nthan O\na O\ndozen O\nfailed O\naccords O\n. O\n\n\" O\nThe O\nsearch O\nfor O\npeace O\nin O\nLiberia B-LOC\nhas O\nbeen O\ndifficult O\n, O\nchallenging O\nand O\nsometimes O\npainful O\n. O\n\nPeacekeepers O\nwere O\nharassed O\n, O\nkilled O\nand O\ntaken O\nhostage O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nIt O\nis O\ndifficult O\nbut O\nI O\nwant O\nto O\nassure O\nyou O\nthat O\npeace O\nis O\nin O\nsight O\n. O\n\" O\n\nUnited B-ORG\nNations I-ORG\nmilitary O\nobservers O\ntravelling O\nto O\nthe O\nwestern O\ntown O\nof O\nTubmanburg B-LOC\non O\nWednesday O\nto O\nmonitor O\nthe O\nceasefire O\nwere O\ndelayed O\nby O\nshooting O\nalong O\nthe O\nhighway O\n, O\nU.N. B-ORG\nspecial O\nrepresentative O\nAnthony B-PER\nNyakyi I-PER\nsaid O\n. O\n\nThey O\nfinally O\nwent O\nahead O\nwith O\nan O\nescort O\nfrom O\nthe O\nULIMO-J B-ORG\nfaction O\n. O\n\nFaction O\nleaders O\nwho O\nagreed O\na O\nnew O\npeace O\ndeal O\nin O\nthe O\nNigerian B-MISC\ncapital O\nAbuja B-LOC\non O\nSaturday O\nhave O\naccused O\neach O\nother O\nof O\nbreaking O\nthe O\nceasefire O\n. O\n\nThe O\nlatest O\npeace O\ndeal O\nforesees O\nthe O\ndisarmament O\nof O\nan O\nestimated O\n60,000 O\ncombatants O\nand O\nsets O\na O\ntarget O\ndate O\nof O\nMay O\n30 O\nnext O\nyear O\nfor O\nelections O\n. O\n\nThe O\nECOMOG B-ORG\nforce O\n, O\ncurrently O\n10,000 O\nstrong O\n, O\nwas O\nsent O\nto O\nLiberia B-LOC\nby O\nthe O\nEconomic B-ORG\nCommunity I-ORG\nof I-ORG\nWest I-ORG\nAfrican I-ORG\nStates I-ORG\nin O\n1990 O\nat O\nthe O\nheight O\nof O\nthe O\nfighting O\n. O\n\n-DOCSTART- O\n\nGuinea B-LOC\ncalls O\ntwo O\ndays O\nof O\nprayer O\n. O\n\nCONAKRY B-LOC\n1996-08-22 O\n\nThe O\nWest B-MISC\nAfrican I-MISC\nstate O\nof O\nGuinea B-LOC\ndeclared O\nThursday O\nand O\nFriday O\ndays O\nof O\nnational O\nprayer O\n. O\n\nA O\ngovernment O\nstatement O\n, O\nbroadcast O\nrepeatedly O\nby O\nstate O\nradio O\n, O\nsaid O\nthe O\ntwo O\ndays O\nof O\nprayer O\nwere O\n\" O\nfor O\nthe O\ndead O\n, O\nfor O\npeace O\nand O\nprosperity O\nin O\nGuinea B-LOC\n, O\nthe O\nvictory O\nof O\nthe O\nnew O\ngovernment O\nand O\nthe O\nhealth O\nof O\nthe O\nhead O\nof O\nstate O\n\" O\n. O\n\nThe O\nprecise O\nreason O\nfor O\nthe O\ncall O\nwas O\nnot O\nimmediately O\nclear O\n. O\n\nGuinea B-LOC\n's O\npresident O\n, O\nLansana B-PER\nConte I-PER\n, O\nvice-president O\nof O\nthe O\nOrganisation B-ORG\nof I-ORG\nthe I-ORG\nIslamic I-ORG\nConference I-ORG\n, O\nleft O\nfor O\nKuwait B-LOC\non O\nAugust O\n16 O\nto O\nprepare O\nthe O\nnext O\nOIC B-ORG\nsummit O\nin O\nPakistan B-LOC\nin O\n1997 O\n. O\n\nKoranic B-MISC\nreading O\nsessions O\nand O\nprayers O\nwere O\nto O\nbe O\nheld O\nin O\nthe O\nfarming O\ntown O\nof O\nBadi-Tondon B-LOC\n, O\nnear O\nhis O\nhome O\nabout O\n60 O\nkm O\n( O\n40 O\nmiles O\n) O\nfrom O\nthe O\ncapital O\nConakry B-LOC\n. O\n\nConte B-PER\n, O\nan O\narmy O\ngeneral O\n, O\nsurvived O\na O\nFebruary O\narmy O\npay O\nrevolt O\nwhich O\nat O\nthe O\ntime O\nhe O\ndescribed O\nas O\na O\nveiled O\nattempt O\nto O\ntopple O\nhim O\n. O\n\nHe O\nhas O\nsince O\nnamed O\na O\nprime O\nminister O\nfor O\nthe O\nfirst O\ntime O\nsince O\nearly O\nin O\nhis O\nrule O\nand O\nordered O\na O\ncrackdown O\non O\ncorruption O\n. O\n\nConte B-PER\nseized O\npower O\nin O\n1984 O\nafter O\nthe O\ndeath O\nof O\nveteran O\nMarxist B-MISC\nleader O\nAhmed B-PER\nSekou I-PER\nToure I-PER\n. O\n\nHe O\nwon O\nelections O\nin O\n1993 O\n. O\n\n-DOCSTART- O\n\nSouth B-MISC\nAfrican I-MISC\nanswers O\nU.S. B-LOC\nmessage O\nin O\na O\nbottle O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-22 O\n\nA O\nSouth B-MISC\nAfrican I-MISC\nboy O\nis O\nwriting O\nback O\nto O\nan O\nAmerican B-MISC\ngirl O\nwhose O\nmessage O\nin O\na O\nbottle O\nhe O\nfound O\nwashed O\nup O\non O\nPresident O\nNelson B-PER\nMandela I-PER\n's O\nold O\nprison O\nisland O\n. O\n\nBut O\nCarlo B-PER\nHoffmann I-PER\n, O\nan O\n11-year-old O\njailer O\n's O\nson O\nwho O\nfound O\nthe O\nbottle O\non O\nthe O\nbeach O\nat O\nRobben B-LOC\nIsland I-LOC\noff O\nCape B-LOC\nTown I-LOC\nafter O\nwinter O\nstorms O\n, O\nwill O\nsend O\nhis O\nletter O\nback O\nby O\nordinary O\nmail O\non O\nThursday O\n, O\nthe O\npost O\noffice O\nsaid O\n. O\n\nIt O\nwill O\nbe O\nsent O\nfor O\nfree O\n. O\n\nDanielle B-PER\nMurray I-PER\nfrom O\nSandusky B-LOC\n, O\nOhio B-LOC\n, O\nthe O\nsame O\nage O\nas O\nher O\nnew O\npenfriend O\n, O\nasked O\nfor O\na O\nreply O\nfrom O\nwhoever O\nreceived O\nthe O\nmessage O\nshe O\nflung O\non O\nits O\njourney O\nmonths O\nago O\non O\nthe O\nother O\nside O\nof O\nthe O\nAtlantic B-LOC\nOcean I-LOC\n. O\n\n-DOCSTART- O\n\nRottweiler B-MISC\nkills O\nSouth B-MISC\nAfrican I-MISC\ntoddler O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-22 O\n\nA O\nrottweiler O\ndog O\nbelonging O\nto O\nan O\nelderly O\nSouth B-MISC\nAfrican I-MISC\ncouple O\nsavaged O\nto O\ndeath O\ntheir O\ntwo-year-old O\ngrandson O\nwho O\nwas O\nvisiting O\n, O\npolice O\nsaid O\non O\nThursday O\n. O\n\nThe O\ndog O\nattacked O\nLouis B-PER\nBooy I-PER\nin O\nthe O\nfront O\ngarden O\nof O\nhis O\ngrandparents O\n' O\nhouse O\nin O\nVanderbijlpark B-LOC\nnear O\nJohannesburg B-LOC\non O\nTuesday O\n. O\n\nHis O\nbloody O\nbody O\nwas O\nlying O\nin O\nthe O\ngarden O\nwhen O\nhis O\nparents O\narrived O\nin O\nthe O\nafternoon O\nto O\npick O\nhim O\nup O\n. O\n\nIt O\nwas O\nunclear O\nwhere O\nthe O\ngrandparents O\nwere O\nat O\nthe O\ntime O\n. O\n\nDogs O\nfierce O\nenough O\nto O\nscare O\noff O\nburglars O\nare O\nbecoming O\nincreasingly O\npopular O\nin O\nthe O\ncrime-infested O\nJohannesburg B-LOC\narea O\n. O\n\n-DOCSTART- O\n\nINDICATORS O\n- O\nHungary B-LOC\n- O\nupdated O\nAug O\n22 O\n. O\n\nBUDAPEST B-LOC\n1996-08-22 O\n\nThe O\nlatest O\nindicators O\n: O\n\nCPI O\n( O\npct O\n) O\nJuly O\n+0.4m O\n/ O\nm O\n; O\n23.0yr O\n/ O\nyr O\n( O\nJune O\n+0.9;+23.6 O\n) O\n\nPPI O\n( O\npct O\n) O\nJune O\n+0.7 O\nm O\n/ O\nm;+21.5yr O\n/ O\nyr O\n( O\nMay O\n+1.7;+22.0 O\n) O\n\nIndustry O\noutput O\n( O\npct O\n) O\nJune O\n- O\n7.8 O\nm O\n/ O\nm;-0.2yr O\n/ O\nyr O\n( O\nMay O\n+7.3;-3.6 O\n) O\n\nCurrent O\naccount O\nJan-May O\n- O\n$ O\n738 O\nmillion O\n( O\nJan-April O\n- O\n$ O\n748 O\nmillion O\n) O\n\nNBH B-ORG\ntrade O\nbalance O\nJan-May O\n- O\n$ O\n934 O\nmillion O\n( O\nJan-April O\n- O\n$ O\n774 O\nmillion O\n) O\n\nMIT B-ORG\ntrade O\nbalance O\nJan-June O\n- O\n$ O\n1.45 O\nbln O\n( O\nJan-May O\n- O\n$ O\n1.24 O\nbln O\n) O\n\nGross O\nforeign O\ndebt O\nMay O\n$ O\n27,246.5 O\nmillion O\n( O\nApril O\n$ O\n28,716.8 O\nmillion O\n) O\n\nNet O\nforeign O\ndebt O\nMay O\n$ O\n14,390.7 O\nmillion O\n( O\nApril O\n$ O\n15,704.3 O\nmillion O\n) O\n\nUnemployment O\n( O\npct O\n) O\nJuly O\n10.8 O\npct O\n( O\nJune O\n10.6 O\npct O\n) O\n\nBudget O\ndeficit O\n( O\nHUF O\n) O\nJan-July O\n102 O\nbln O\n( O\nJan-June O\n122 O\nbln O\n) O\n\nT-bill O\nyields O\n% O\n( O\n1mo O\n) O\n22.95 O\n( O\n3mo O\n) O\n23.02 O\n( O\n6mo O\n) O\n23.53 O\n( O\n1yr O\n) O\n24.40 O\n\nGovernment O\nbond O\nyields O\n: O\n( O\n2-yr O\n1998 O\n/ O\nJ O\n) O\n25.49,(3-yr O\n1999 O\n/ O\nc O\n) O\n24.44 O\n\nThe O\nNBH B-ORG\nis O\nBBB-minus O\nby O\nDuff B-ORG\n& I-ORG\nPhelps I-ORG\n, O\nIBCA B-ORG\nand O\nThomson B-ORG\nBankWatch I-ORG\n, O\nBB-plus O\nby O\nS&P B-ORG\n, O\nBA1 O\nby O\nMoody B-ORG\n's I-ORG\nInvestors I-ORG\nService I-ORG\n, O\nBBB+ O\nby O\nthe O\nJapan B-ORG\nCredit I-ORG\nRating I-ORG\nAgency I-ORG\n. O\n\nThe O\nNBH B-ORG\ntrade O\ndata O\nis O\nbased O\non O\ncash O\nflow O\n, O\nMIT B-ORG\ndata O\non O\ncustoms O\nstatistics O\n. O\n\n-- O\nBudapest B-LOC\nnewsroom O\n( O\n36 O\n1)266 O\n2410 O\n\n-DOCSTART- O\n\nFifty O\nRussians B-MISC\ndie O\nin O\nclash O\nwith O\nrebels-Interfax O\n. O\n\nMOSCOW B-LOC\n1996-08-22 O\n\nAt O\nleast O\n50 O\nRussian B-MISC\nservicemen O\nhave O\nbeen O\nkilled O\nin O\na O\nbattle O\nwith O\nseparatist O\nrebels O\nwhich O\nerupted O\nin O\nthe O\nChechen B-MISC\ncapital O\nGrozny B-LOC\non O\nThursday O\nand O\ncontinued O\nafter O\nRussia B-LOC\nand O\nthe O\nrebels O\nagreed O\na O\ntruce O\n, O\nInterfax B-ORG\nnews O\nagency O\nsaid O\n. O\n\nInterfax B-ORG\nquoted O\nRussian B-MISC\nmilitary O\ncommand O\nin O\nChechnya B-LOC\nas O\nsaying O\nthat O\nabout O\n200 O\ninterior B-ORG\nministry I-ORG\nforces O\n, O\nsent O\non O\nreconaisance O\nmission O\n, O\nclashed O\nwith O\nrebels O\nat O\nMinutka B-LOC\nSquare I-LOC\n. O\n\nThe O\nInterfax B-ORG\nreport O\ncould O\nnot O\nbe O\nindependently O\nconfirmed O\n. O\n\nMoscow B-LOC\npeacemaker O\nAlexander B-PER\nLebed I-PER\nand O\nrebel O\nchief-of-staff O\nAslan B-PER\nMaskhadov I-PER\nsigned O\nan O\nagreement O\nearlier O\non O\nThursday O\nunder O\nwhich O\nthe O\ntwo O\nsides O\nwould O\ncease O\nall O\nhostilities O\nat O\nnoon O\n( O\n0800 O\nGMT B-MISC\n) O\non O\nFriday O\n. O\n\nInterfax B-ORG\nmade O\nclear O\nthat O\nthe O\ninterior B-ORG\nministry I-ORG\ndetachment O\nhad O\nbeen O\nsent O\non O\nthe O\nmission O\nbefore O\nthe O\ntruce O\ndeal O\nhad O\nbeen O\nsigned O\nat O\nthe O\nlocal O\nequivalent O\nof O\n1500 O\nGMT B-MISC\n. O\n\nBut O\nfierce O\nfighting O\nstill O\nraged O\nat O\n1600 O\nGMT B-MISC\n, O\nInterfax B-ORG\nsaid O\n. O\n\nIt O\nquoted O\na O\nsource O\nin O\nthe O\nRussian B-MISC\ncommand O\nin O\nChechnya B-LOC\nas O\nsaying O\nthat O\nthe O\nservicemen O\nwere O\noutnumbered O\nby O\nthe O\nrebels O\n. O\n\n-DOCSTART- O\n\nPolish B-MISC\nschoolgirl O\nblackmailer O\nwanted O\ntextbooks O\n. O\n\nGDANSK B-LOC\n, O\nPoland B-LOC\n1996-08-22 O\n\nA O\nPolish B-MISC\nschoolgirl O\nblackmailed O\ntwo O\nwomen O\nwith O\nanonymous O\nletters O\nthreatening O\ndeath O\nand O\nlater O\nexplained O\nthat O\nshe O\nneeded O\nmoney O\nfor O\ntextbooks O\n, O\npolice O\nsaid O\non O\nThursday O\n. O\n\n\" O\nThe O\n13-year-old O\ngirl O\ntried O\nto O\nextract O\n60 O\nand O\n70 O\nzlotys O\n( O\n$ O\n22 O\nand O\n$ O\n26 O\n) O\nfrom O\ntwo O\nresidents O\nof O\nSierakowice B-LOC\nby O\nthreatening O\nto O\ntake O\ntheir O\nlives O\n, O\n\" O\na O\npolice O\nspokesman O\nsaid O\nin O\nthe O\nnearby O\nnorthern O\ncity O\nof O\nGdansk B-LOC\non O\nThursday O\n. O\n\nHe O\nsaid O\nthe O\nwomen O\nreported O\nthe O\nblackmail O\nletters O\nand O\npolice O\ncaught O\nthe O\ngirl O\non O\nWednesday O\nas O\nshe O\ntried O\nto O\npick O\nup O\nthe O\ncash O\nat O\nthe O\nSierakowice B-LOC\nrailway O\nstation O\n. O\n\n\" O\nInterviewed O\nin O\nthe O\npresence O\nof O\na O\npsychologist O\n, O\nshe O\nsaid O\nshe O\nwanted O\nto O\nuse O\nthe O\nmoney O\nfor O\nschool O\nbooks O\nand O\nclothes O\n, O\n\" O\nspokesman O\nKazimierz B-PER\nSocha I-PER\ntold O\nReuters B-ORG\n. O\n\nHe O\nsaid O\nthe O\ncase O\nof O\nthe O\ngirl O\n, O\nfrom O\na O\npoor O\nfamily O\nthat O\nhad O\nnever O\nbeen O\nin O\ntrouble O\nwith O\nthe O\nlaw O\n, O\nwould O\ngo O\nbefore O\na O\nspecial O\ncourt O\ndealing O\nwith O\nunderage O\noffenders O\n. O\n\n-DOCSTART- O\n\nCzech B-MISC\nCNB-120 B-MISC\nindex O\nrises O\n1.2 O\npts O\nto O\n869.3 O\n. O\n\nPRAGUE B-LOC\n1996-08-22 O\n\nThe O\nCNB-120 B-MISC\nindex O\n, O\na O\nbroad O\ndaily O\nmeasure O\nof O\nCzech B-MISC\nequities O\n, O\nrose O\n1.2 O\npoints O\non O\nThursday O\nto O\n869.3 O\n, O\nthe O\nCzech B-ORG\nNational I-ORG\nBank I-ORG\n( O\nCNB B-ORG\n) O\nsaid O\n. O\n\nEight O\nof O\nthe O\nten O\nsectoral O\nindices O\nrose O\n, O\nwith O\nthe O\nbanking O\nindex O\nrising O\nthe O\nmost O\n, O\nup O\n14.4 O\npoints O\nto O\n1,294.5 O\n. O\n\n-- O\nPrague B-ORG\nNewsroom I-ORG\n, O\n42-2-2423-0003 O\n\n-DOCSTART- O\n\nRussians B-MISC\n, O\nrebels O\nsign O\ndeal O\nin O\nChechnya B-LOC\n. O\n\nNOVYE B-LOC\nATAGI I-LOC\n, O\nRussia B-LOC\n1996-08-22 O\n\nRussian B-MISC\nPresident O\nBoris B-PER\nYeltsin I-PER\n's O\nsecurity O\nsupremo O\nAlexander B-PER\nLebed I-PER\nand O\nChechen B-MISC\nrebel O\nchief-of-staff O\nAslan B-PER\nMaskhadov I-PER\nsigned O\na O\ndeal O\non O\nThursday O\naimed O\nat O\nending O\nthree O\nweeks O\nof O\nrenewed O\nfighting O\nin O\nthe O\nregion O\n. O\n\nThe O\nfinal O\ncontents O\nof O\nthe O\ndocument O\nnegotiated O\nin O\nthis O\nvillage O\nsouth O\nof O\nthe O\nChechen B-MISC\ncapital O\nGrozny B-LOC\nhave O\nnot O\nbeen O\nofficially O\ndisclosed O\n. O\n\nItar-Tass B-ORG\nnews O\nagency O\nsaid O\nit O\nprovided O\nfor O\nthe O\ndisengagement O\nof O\nRussian B-MISC\nand O\nrebel O\nforces O\nin O\nChechnya B-LOC\n. O\n\n-DOCSTART- O\n\nLebed B-PER\naide O\nsays O\nRussian-Chechen B-MISC\ntalks O\ngoing O\nwell O\n. O\n\nNOVYE B-LOC\nATAGI I-LOC\n, O\nRussia B-LOC\n1996-08-22 O\n\nTalks O\nbetween O\nRussia B-LOC\n's O\nAlexander B-PER\nLebed I-PER\nand O\nChechen B-MISC\nseparatist O\nleaders O\nwere O\ngoing O\nwell O\non O\nThursday O\nand O\nthe O\ntwo O\nsides O\nwere O\nworking O\nout O\na O\ndetailed O\nschedule O\non O\nhow O\nto O\nstop O\nthe O\nwar O\n, O\na O\nLebed B-PER\naide O\nsaid O\n. O\n\nPress O\nspokesman O\nAlexander B-PER\nBarkhatov I-PER\ntold O\nreporters O\nthe O\nnegotiations O\n, O\nbeing O\nheld O\nat O\nthis O\nrebel-held O\nvillage O\nsome O\n20 O\nkm O\n( O\n12 O\nmiles O\n) O\nsouth O\nof O\nthe O\nChechen B-MISC\ncapital O\nGrozny B-LOC\n, O\nwere O\nprogressing O\nbriskly O\nand O\nbeing O\nconducted O\nin O\na O\ngood O\nmood O\n. O\n\nHe O\nsaid O\na O\ndocument O\nwould O\nbe O\ncompleted O\nin O\nan O\nhour O\n's O\ntime O\nfor O\nsignature O\nby O\nthe O\ntwo O\nsides O\n, O\nwho O\nwere O\nworking O\non O\na O\n\" O\nday-by-day O\nschedule O\nto O\nstop O\nthe O\nwar O\nin O\nChechnya B-LOC\n. O\n\" O\n\n-DOCSTART- O\n\nYeltsin B-PER\nshown O\non O\nRussian B-MISC\ntelevision O\n. O\n\nMOSCOW B-LOC\n1996-08-22 O\n\nRussian B-MISC\ntelevision O\nshowed O\na O\nbrief O\nclip O\nof O\nBoris B-PER\nYeltsin I-PER\non O\nThursday O\n, O\nwith O\nthe O\npresident O\nlaughing O\nand O\nsmiling O\nas O\nhe O\nspoke O\nto O\nnominee O\nhealth O\nminister O\nTatyana B-PER\nDmitrieva I-PER\n. O\n\nIt O\nwas O\nthe O\nfirst O\ntime O\nthe O\npresident O\nhad O\nbeen O\nshown O\non O\ntelevision O\nsince O\nhe O\nwas O\ninaugurated O\nfor O\na O\nsecond O\nterm O\nin O\noffice O\non O\nAugust O\n9 O\n. O\n\nHe O\nreturned O\nto O\nthe O\nKremlin B-LOC\non O\nThursday O\nafter O\na O\ntwo-day O\nbreak O\nin O\nthe O\nlakelands O\nof O\nnorthwestern O\nRussia B-LOC\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nBosnia B-LOC\n- O\nAug O\n22 O\n. O\n\nSARAJEVO B-LOC\n1996-08-22 O\n\nThese O\nare O\nthe O\nleading O\nstories O\nin O\nthe O\nSarajevo B-LOC\npress O\non O\nThursday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nOSLOBODJENJE B-ORG\n\n- O\nThe O\nBosnian B-MISC\nfederation O\nlaunches O\na O\ncommon O\npayment O\nsystem O\non O\nFriday O\n. O\n\nUnder O\nthe O\nnew O\nsystem O\ntaxes O\nand O\ncustoms O\nmay O\nbe O\npaid O\nin O\nthe O\nBosnian B-MISC\ndinar O\n, O\nthe O\nCroatian B-MISC\nkuna O\nor O\nthe O\nDeutsche O\nmark O\nuntil O\na O\nnew O\nBosnian B-MISC\ncurrency O\nis O\nintroduced O\n. O\n\n- O\nThe O\npresident O\nof O\nthe O\nBosnian B-ORG\nAssociation I-ORG\nfor I-ORG\nRefugees I-ORG\nand I-ORG\nDisplaced I-ORG\nPersons I-ORG\n, O\nMirhunisa B-PER\nKomarica I-PER\nsays O\nmany O\nsurvivors O\nof O\nthe O\n1995 O\nmassacre O\nin O\nthe O\nBosnian B-MISC\ntown O\nof O\nSrebrenica B-LOC\nare O\nlanguishing O\nas O\nforced O\nlaborers O\nin O\nSerbian B-MISC\nmines O\n. O\n\nAccording O\nto O\nKomarica B-PER\n, O\n2,400 O\nmale O\nresidents O\nof O\nSrebrenica B-LOC\nwork O\nin O\nthe O\nTrepca B-LOC\nmine O\nand O\n1,900 O\nwork O\nin O\na O\nmine O\nin O\nAleksandrovac B-LOC\n. O\n\nDNEVNI B-ORG\nAVAZ I-ORG\n\n- O\nSlovenian B-MISC\npolice O\nbriefly O\ndetain O\ntwo O\nBosnian B-MISC\nopposition O\nleaders O\nin O\nLjubljana B-LOC\nand O\ncancel O\nopposition O\npolitical O\nrallies O\nin O\nLjubljana B-LOC\nand O\nMaribor B-LOC\n. O\n\n-- O\nSarajevo B-LOC\nnewsroom O\n, O\n+387-71-663-864 O\n. O\n\n-DOCSTART- O\n\nGrozny B-LOC\nquiet O\novernight O\nafter O\nraids O\n. O\n\nALKHAN-YURT B-LOC\n, O\nRussia B-LOC\n1996-08-22 O\n\nThe O\ncity O\nof O\nGrozny B-LOC\n, O\npounded O\nby O\nRussian B-MISC\nplanes O\nand O\nartillery O\nfor O\nhours O\non O\nWednesday O\n, O\ncalmed O\ndown O\novernight O\n, O\nalthough O\nsporadic O\nexplosions O\nand O\nshooting O\ncould O\nstill O\nbe O\nheard O\n. O\n\nReuters B-ORG\ncorrespondent O\nLawrence B-PER\nSheets I-PER\n, O\nspeaking O\nfrom O\nthe O\nnearby O\nvillage O\nof O\nAlkhan-Yurt B-LOC\n, O\nsaid O\nhe O\nhad O\nheard O\nlittle O\nfrom O\nGrozny B-LOC\nsince O\nWednesday O\nevening O\n's O\narrival O\nof O\nRussian B-MISC\nsecurity O\nchief O\nAlexander B-PER\nLebed I-PER\n, O\nwho O\nsaid O\nhe O\n\" O\ncame O\nwith O\npeace O\n\" O\n. O\n\nA O\ncouple O\nof O\nhelicopters O\nflew O\nover O\nthe O\ncity O\nearly O\non O\nThursday O\nmorning O\n, O\nbut O\ndid O\nnot O\nappear O\nto O\nbe O\nfiring O\nat O\nanything O\n. O\n\nLebed B-PER\nsaid O\non O\nWednesday O\nhe O\nhad O\nclinched O\na O\ntruce O\nwith O\nChechen B-MISC\nseparatists O\nand O\nhe O\npromised O\nto O\nhalt O\na O\nthreatened O\nbombing O\nassault O\non O\nGrozny B-LOC\n, O\nwhich O\nthe O\nrebels O\nhave O\nheld O\nsince O\nAugust O\n6 O\n. O\n\n-DOCSTART- O\n\nBoat O\npassengers O\nrescued O\noff O\nColombian B-MISC\ncoast O\n. O\n\nBOGOTA B-LOC\n, O\nColombia B-LOC\n1996-08-22 O\n\nColombia B-LOC\n's O\nCoast B-ORG\nGuard I-ORG\non O\nThursday O\nrescued O\n12 O\npeople O\nlost O\nfor O\nthree O\ndays O\nin O\nan O\nopen O\nboat O\noff O\nthe O\nPacific B-LOC\ncoast O\n, O\nofficials O\nsaid O\n. O\n\nThe O\nboat O\nhad O\nbeen O\nmissing O\nsince O\nMonday O\nafternoon O\nwhen O\nit O\nleft O\nthe O\ntiny O\nisland O\nof O\nGorgona B-LOC\noff O\nColombia B-LOC\n's O\nsouthwest O\ncoast O\nwith O\nsightseers O\nfor O\na O\nreturn O\ntrip O\nto O\nNarino B-LOC\nprovince O\n, O\nnear O\nthe O\nborder O\nwith O\nEcuador B-LOC\n. O\n\nThe O\nboat O\nran O\nout O\nof O\nfuel O\nand O\ndid O\nnot O\nhave O\na O\nradio O\nto O\ncall O\nfor O\nhelp O\n, O\nNavy B-ORG\nspokesman O\nLt. O\nItalo B-PER\nPineda I-PER\nsaid O\n. O\n\nHe O\nsaid O\n11 O\npassengers O\nand O\none O\nboatman O\nsurvived O\non O\ncoconuts O\nand O\nrainwater O\nduring O\n65 O\nhours O\nlost O\nat O\nsea O\n. O\n\nThe O\nboat O\nwas O\ntowed O\nto O\nthe O\nport O\ncity O\nof O\nBuenaventura B-LOC\n. O\n\n-DOCSTART- O\n\nArgentine B-MISC\nJuly O\nraw O\nsteel O\noutput O\nup O\n14.8 O\npct O\nvs O\n' O\n95 O\n. O\n\nBUENOS B-LOC\nAIRES I-LOC\n1996-08-22 O\n\nArgentine B-MISC\nraw O\nsteel O\noutput O\nwas O\n355,900 O\ntonnes O\nin O\nJuly O\n, O\n14.8 O\npercent O\nhigher O\nthan O\nin O\nJuly O\n1995 O\nand O\nup O\n1.9 O\npercent O\nfrom O\nJune O\n, O\nSteel B-ORG\nIndustry I-ORG\nCenter I-ORG\nsaid O\nThursday O\n. O\n\nPrimary O\niron O\noutput O\nwas O\n297,700 O\ntonnes O\n, O\n14.5 O\npercent O\nmore O\nthan O\nlast O\nJuly O\nand O\n0.1 O\npercent O\nmore O\nthan O\nin O\nJune O\n. O\n\nHot O\nlaminate O\nproduction O\nwas O\n349,000 O\ntonnes O\n, O\n3.2 O\npercent O\nup O\nfrom O\nJuly O\n1995 O\nand O\n0.8 O\npercent O\nup O\nfrom O\nJune O\n. O\n\nProduction O\nof O\ncold O\nlaminates O\nwas O\n120,500 O\ntonnes O\n, O\n4.2 O\npercent O\nhigher O\nthan O\nthe O\nsame O\nmonth O\nlast O\nyear O\nand O\n11 O\npercent O\nhigher O\nthan O\nin O\nJune O\n. O\n\n-- O\nJason B-PER\nWebb I-PER\n, O\nBuenos B-ORG\nAires I-ORG\nNewsroom I-ORG\n+541 O\n318-0655 O\n\n-DOCSTART- O\n\nPeru B-LOC\n's O\nguerrillas O\nkill O\none O\n, O\ntake O\n8 O\nhostage O\nin O\njungle O\n. O\n\nLIMA B-LOC\n, O\nPeru B-LOC\n1996-08-21 O\n\nPeruvian B-MISC\nguerrillas O\nkilled O\none O\nman O\nand O\ntook O\neight O\npeople O\nhostage O\nafter O\ntaking O\nover O\na O\nvillage O\nin O\nthe O\ncountry O\n's O\nnortheastern O\njungle O\nregion O\n, O\nanti- O\nterrorist O\npolice O\nsources O\nsaid O\non O\nWednesday O\n. O\n\nFor O\nthree O\nhours O\non O\nTuesday O\n, O\naround O\n100 O\nmembers O\nof O\nthe O\nMaoist B-MISC\nrebel O\ngroup O\nShining B-ORG\nPath I-ORG\ntook O\ncontrol O\nof O\nAlomella B-LOC\nRobles I-LOC\n, O\na O\nsmall O\nvillage O\nabout O\n345 O\nmiles O\n( O\n550 O\nkm O\n) O\nnortheast O\nof O\nLima B-LOC\n, O\nthe O\nsources O\nsaid O\n. O\n\nSome O\nguerrillas O\nmade O\nvillagers O\nlisten O\nto O\npropaganda O\nspeeches O\nin O\nthe O\nvillage O\ncentre O\n, O\nothers O\nforced O\npassing O\nmotorists O\nout O\nof O\ntheir O\ncars O\nand O\ndaubed O\ntheir O\nvehicles O\nwith O\nslogans O\n. O\n\nBy O\nWednesday O\n, O\nthe O\nwhereabouts O\nof O\nthe O\neight O\nhostages O\nwas O\nstill O\nnot O\nknown O\n, O\nthe O\nsources O\nsaid O\n. O\n\nIn O\nrecent O\nmonths O\nthe O\nShining B-ORG\nPath I-ORG\n, O\nseverely O\nweakened O\nsince O\nthe O\n1992 O\ncapture O\nof O\nits O\nleader O\nAbimael B-PER\nGuzman I-PER\n, O\nhas O\nbeen O\nstepping O\nup O\nboth O\nits O\nmilitary O\nand O\npropaganda O\nactivities O\n. O\n\nPeru B-LOC\n's O\nguerrilla O\nconflicts O\nhave O\ncost O\nat O\nleast O\n30,000 O\nlives O\nand O\n$ O\n25 O\nbillion O\nin O\ndamage O\nto O\ninfrastructure O\nsince O\n1980 O\n. O\n\n-DOCSTART- O\n\nFormer O\nSurinam B-LOC\nrebel O\nleader O\nheld O\nafter O\nshooting O\n. O\n\nPARAMARIBO B-LOC\n, O\nSurinam B-LOC\n1996-08-21 O\n\nFlamboyant O\nformer O\nSurinamese B-MISC\nrebel O\nleader O\nRonny B-PER\nBrunswijk I-PER\nwas O\nin O\ncustody O\non O\nWednesday O\ncharged O\nwith O\nattempted O\nmurder O\n, O\npolice O\nsaid O\n. O\n\nBrunswijk B-PER\nturned O\nhimself O\ninto O\npolice O\nafter O\nFreddy B-PER\nPinas I-PER\n, O\na O\nSurinamese-born B-MISC\nvisitor O\nfrom O\nthe O\nNetherlands B-LOC\n, O\naccused O\nBrunswijk B-PER\nof O\ntrying O\nto O\nkill O\nhim O\non O\nSunday O\nafter O\na O\nbar-room O\nbrawl O\nin O\nthe O\nsmall O\nmining O\ntown O\nof O\nMoengo B-LOC\n, O\nabout O\n56 O\nmiles O\n( O\n90 O\nkm O\n) O\neast O\nof O\nParamaribo B-LOC\n, O\nsaid O\npolice O\nspokesman O\nRo B-PER\nGajadhar I-PER\n. O\n\nPinas B-PER\n, O\nshowing O\ncuts O\nand O\nbruises O\non O\nhis O\nface O\n, O\ntold O\nreporters O\nthe O\nformer O\nhead O\nof O\nthe O\nfeared O\nJungle B-ORG\nCommand I-ORG\nhad O\ntried O\nand O\nfailed O\nto O\nshoot O\nhim O\nafter O\nPinas B-PER\nobjected O\nto O\nBrunswijk B-PER\n's O\nadvances O\ntoward O\nhis O\nwife O\n. O\n\nPinas B-PER\nsaid O\nBrunswijk B-PER\nthen O\nordered O\nhis O\nbodyguards O\nto O\nbeat O\nhim O\nup O\n. O\n\nBrunswijk B-PER\n, O\n35 O\n, O\ndenied O\nthe O\ncharges O\nand O\nsaid O\nhe O\nhad O\nmerely O\ndefended O\nhimself O\nwhen O\nPinas B-PER\nattacked O\nhim O\nwith O\na O\nbottle O\n. O\n\nIt O\nwas O\nthe O\nsecond O\ntime O\nBrunswijk B-PER\nhad O\nbeen O\ncharged O\nwith O\nattempted O\nmurder O\nin O\nless O\nthan O\ntwo O\nyears O\n. O\n\nIn O\n1994 O\nhe O\nserved O\ntwo O\nmonths O\nin O\nprison O\nfor O\nshooting O\na O\nthief O\nin O\nthe O\nbuttocks O\n. O\n\nBrunswijk B-PER\nled O\na O\nrebel O\ngroup O\nof O\nabout O\n1,000 O\nin O\na O\n1986 O\nuprising O\nagainst O\nthe O\nregime O\nof O\nmilitary O\nstrongman O\nDesi B-PER\nBouterse I-PER\n. O\n\nThe O\nconflict O\n, O\nwhich O\nkilled O\nmore O\nthan O\n500 O\nand O\ncaused O\nthousands O\nto O\nflee O\nto O\nneighbouring O\nFrench B-LOC\nGuiana I-LOC\nin O\nthe O\nlate O\n1980s O\n, O\neventually O\npaved O\nthe O\nway O\nto O\ndemocratic O\nelections O\nin O\n1991 O\n. O\n\nDespite O\nnumerous O\nproblems O\nwith O\nauthorities O\n, O\nBrunswijk B-PER\nwent O\non O\nto O\nbecome O\na O\nsuccessful O\nbusinessman O\nwith O\nmining O\nand O\nlogging O\ninterests O\n. O\n\nHe O\nalso O\nmanages O\nand O\noccasionally O\nplays O\nfor O\none O\nof O\nthe O\nleading O\nlocal O\nsoccer O\nteams O\n. O\n\n-DOCSTART- O\n\nNoisy O\nsaw O\nleads O\nThai B-MISC\npolice O\nto O\nheroin O\nhideaway O\n. O\n\nBANGKOK B-LOC\n1996-08-22 O\n\nA O\nHong B-LOC\nKong I-LOC\ncarpenter O\nwas O\narrested O\nin O\nthe O\nThai B-MISC\nseaside O\ntown O\nof O\nPattaya B-LOC\nafter O\npolice O\nseized O\n18 O\nkg O\n( O\n39.7 O\npounds O\n) O\nof O\nheroin O\nfollowing O\ncomplaints O\nby O\nresidents O\nof O\na O\nnoisy O\nsaw O\n, O\npolice O\nsaid O\non O\nThursday O\n. O\n\nCheung B-PER\nSiu I-PER\nMan I-PER\n, O\n40 O\n, O\nwas O\narrested O\nlate O\non O\nWednesday O\nafter O\npolice O\nsearched O\na O\nhouse O\nand O\nfound O\nheroin O\nin O\nbags O\nand O\nhidden O\nin O\nhollow O\nspaces O\nin O\nwooden O\nplanks O\n, O\npolice O\nsaid O\n. O\n\nThe O\nsuspect O\nsaid O\nhe O\nwas O\nhired O\nto O\nmake O\na O\nwooden O\nbox O\nfrom O\nthe O\nplanks O\nin O\norder O\nto O\nhide O\nthe O\nheroin O\n. O\n\nPolice O\nwent O\nto O\nthe O\nhouse O\nafter O\nreceiving O\ncomplaints O\nof O\nsawing O\nduring O\nthe O\nnight O\nover O\nthe O\ncourse O\nof O\nseveral O\ndays O\n. O\n\nWhen O\nthey O\narrived O\nto O\ninvestigate O\n, O\npolice O\nsaw O\npeople O\nescaping O\nfrom O\nthe O\nback O\ndoor O\nso O\nthey O\ndecided O\nto O\nsearch O\nthe O\nhouse O\n. O\n\nThe O\nseized O\nheroin O\nhas O\nan O\nestimated O\nstreet O\nvalue O\nof O\nabout O\n300 O\nmillion O\nbaht O\n( O\n$ O\n12 O\nmillion O\n) O\n, O\npolice O\nsaid O\n. O\n\nOfficials O\nare O\nnow O\nhunting O\nfor O\nthe O\nsuspect O\n's O\ncollaborators O\n, O\npolice O\nsaid O\n. O\n\nCheung B-PER\nwas O\nbeing O\ndetained O\npending O\nformal O\ncharges O\n, O\npolice O\nsaid O\n. O\n\n-DOCSTART- O\n\nAustralia B-LOC\nforeign O\nminister O\narrives O\nin O\nChina B-LOC\n. O\n\nBEIJING B-LOC\n1996-08-22 O\n\nAustralian B-MISC\nForeign O\nMinister O\nAlexander B-PER\nDowner I-PER\narrived O\nin O\nBeijing B-LOC\non O\nThursday O\nfor O\na O\nfour-day O\nvisit O\nthat O\nfollows O\nrising O\nfriction O\nbetween O\nthe O\ntwo O\nnations O\nin O\nrecent O\nweeks O\n. O\n\nDowner B-PER\nwas O\nto O\nmeet O\nChinese B-MISC\nForeign O\nMinister O\nQian B-PER\nQichen I-PER\nand O\nsign O\nan O\nagreement O\non O\nan O\nAustralian B-MISC\nconsulate O\nin O\nHong B-LOC\nKong I-LOC\n, O\nan O\nofficial O\nof O\nthe O\nAustralian B-MISC\nembassy O\nin O\nBeijing B-LOC\nsaid O\n. O\n\nChina B-LOC\nwill O\nresume O\nsovereignty O\nover O\nHong B-LOC\nKong I-LOC\n, O\na O\nBritish B-MISC\ncolony O\n, O\nin O\nmid-1997 O\n. O\n\nRelations O\nbetween O\nChina B-LOC\nand O\nAustralia B-LOC\nhave O\nbeen O\nstrained O\nin O\nrecent O\nweeks O\nbecause O\nof O\nAustralia B-LOC\n's O\nplan O\nto O\nsell O\nuranium O\nto O\nChina B-LOC\n's O\nrival O\nTaiwan B-LOC\n. O\n\nOther O\nissues O\naffecting O\nties O\ninclude O\nplans O\nby O\nan O\nAustralian B-MISC\ncabinet O\nminister O\nto O\nvisit O\nTaiwan B-LOC\n, O\na O\nsecurity O\npact O\nbetween O\nCanberra B-LOC\nand O\nWashington B-LOC\nand O\na O\npossible O\nvisit O\nto O\nAustralia B-LOC\nnext O\nmonth O\nby O\nTibet B-LOC\n's O\nexiled O\nspiritual O\nleader O\nthe O\nDalai B-PER\nLama I-PER\n. O\n\nDowner B-PER\nis O\nthe O\nfirst O\nAustralian B-MISC\nminister O\nto O\nvisit O\nChina B-LOC\nsince O\nthe O\nnew O\nconservative O\ngovernment O\ntook O\noffice O\nin O\nCanberra B-LOC\nin O\nMarch O\n. O\n\n-DOCSTART- O\n\nPalestinians B-MISC\naccuse O\nPA B-ORG\nof O\nbanning O\nbooks O\n. O\n\nNABLUS B-LOC\n, O\nWest B-LOC\nBank I-LOC\n1996-08-22 O\n\nA O\nWest B-LOC\nBank I-LOC\nbookseller O\ncharged O\non O\nThursday O\nthat O\nthe O\nPalestinian B-ORG\nInformation I-ORG\nMinistry I-ORG\nhas O\nforced O\nhim O\nto O\nsign O\nan O\nundertaking O\nnot O\nto O\ndistribute O\nbooks O\nwritten O\nby O\ncritics O\nof O\nIsraeli-PLO B-MISC\nself-rule O\ndeals O\n. O\n\n\" O\nThey O\nmade O\nme O\nsign O\nan O\nundertaking O\nnot O\nto O\nsell O\nthe O\nbooks O\nto O\nanyone O\nat O\nthe O\nrisk O\nof O\nlegal O\naction O\n. O\n\nOne O\nofficial O\ntold O\nme O\n' O\nyou O\nhave O\nto O\neither O\ndestroy O\nthe O\nbooks O\nor O\nreturn O\nthem O\nto O\nAmman B-LOC\n' O\n, O\n\" O\nDaoud B-PER\nMakkawi I-PER\n, O\nowner O\nof O\nthe O\nNablus-based B-MISC\nal-Risala B-LOC\nbookshop O\n, O\ntold O\nReuters B-ORG\n. O\n\nHe O\nsaid O\nministry O\nofficials O\nmade O\nhim O\nsign O\nthis O\na O\nfew O\nweeks O\nago O\nafter O\nhe O\nbrought O\nabout O\na O\ndozen O\ncopies O\nfrom O\nJordan B-LOC\nof O\na O\nbook O\nby O\nEdward B-PER\nSaid I-PER\n, O\na O\nprominent O\nscholar O\nat O\nNew B-LOC\nYork I-LOC\nCity I-LOC\n's O\nColumbia B-ORG\nUniversity I-ORG\n. O\n\nSaid B-PER\n, O\na O\nU.S. B-LOC\ncitizen O\nof O\nPalestinian B-MISC\norigin O\n, O\nhas O\nbeen O\nan O\noutspoken O\ncritic O\nof O\nthe O\n1993 O\nIsraeli-PLO B-MISC\nself-rule O\ndeal O\nand O\nhas O\nwritten O\nat O\nleast O\ntwo O\nbooks O\non O\nthe O\naccord O\n. O\n\nOn O\nWednesday O\na O\nbookseller O\nin O\nthe O\nWest B-LOC\nBank I-LOC\ntown O\nof O\nRamallah B-LOC\nsaid O\npolice O\nabout O\na O\nmonth O\nago O\nconfiscated O\nseveral O\ncopies O\nof O\ntwo O\nof O\nSaid B-PER\n's O\nbooks O\non O\nthe O\nIsrael-PLO B-MISC\nself-rule O\ndeals O\n. O\n\nPalestinian B-ORG\nInformation I-ORG\nMinistry I-ORG\nDirector-General O\nMutawakel B-PER\nTaha I-PER\ndenied O\nthat O\nministry O\nofficials O\nforced O\nanyone O\nto O\nsign O\nany O\nundertaking O\nand O\ninsisted O\nthat O\nthe O\nPalestinian B-ORG\nAuthority I-ORG\nhas O\nno O\nplans O\nto O\ncensor O\nbooks O\n. O\n\n\" O\nThere O\nis O\nno O\nstrategy O\nto O\nban O\nbooks O\nor O\nto O\nsuppress O\nfreedom O\nof O\nexpression O\nin O\nany O\nform O\nwhatsoever O\n, O\n\" O\nTaha B-PER\ntold O\nReuters B-ORG\n. O\n\nBut O\nTaha B-PER\nsaid O\nthat O\nthe O\nabsence O\nof O\nrelevent O\nlegislations O\nmay O\nhave O\nresulted O\nin O\nsome O\nmistakes O\nby O\nsome O\nsecurity O\nofficials O\n. O\n\n\" O\nThis O\nmay O\nexplain O\nsome O\nmistakes O\nagainst O\nsome O\njournalists O\nand O\nwriters O\n, O\n\" O\nhe O\nsaid O\n. O\n\nDaoud B-PER\nsaid O\nbooks O\nby O\nother O\nauthors O\n, O\nincluding O\nBritish B-MISC\nJournalist O\nPatrick B-PER\nSeale I-PER\n, O\nwere O\nalso O\nbanned O\n. O\n\nHe O\nsaid O\nthat O\nsecurity O\nofficials O\noften O\nvisit O\nhis O\nshop O\nto O\nmake O\nsure O\nhe O\nwas O\nnot O\nselling O\nthe O\nbooks O\n. O\n\n\" O\nI O\nthink O\nthis O\nis O\na O\nbad O\nbeginning O\n. O\n\nIf O\nwe O\nhave O\nconfidence O\n, O\nwhy O\nshould O\nwe O\nbe O\nafraid O\nof O\nthe O\nother O\nopinion O\n? O\n\" O\n\nDaoud B-PER\nsaid O\n. O\n\nThousands O\nof O\nbooks O\nwere O\nbanned O\nfrom O\nsale O\nin O\nthe O\nWest B-LOC\nBank I-LOC\nand O\nGaza B-LOC\nStrip I-LOC\nby O\nthe O\nIsraeli B-MISC\nmilitary O\nauthorities O\nbefore O\nthe O\nJewish B-MISC\nstate O\nhanded O\nover O\nparts O\nof O\nthe O\ntwo O\nareas O\nto O\nthe O\nPLO B-ORG\nunder O\na O\nself-rule O\ndeal O\nin O\n1994 O\n. O\n\n-DOCSTART- O\n\nEgypt B-LOC\nblames O\nIstanbul B-LOC\ncontrol O\ntower O\nfor O\naccident O\n. O\n\nCAIRO B-LOC\n1996-08-22 O\n\nThe O\nchairman O\nof O\nnational O\ncarrier O\nEgyptAir B-ORG\non O\nThursday O\nblamed O\nthe O\ncontrol O\ntower O\nat O\nIstanbul B-LOC\nairport O\nfor O\nthe O\nEgyptAir B-ORG\nplane O\naccident O\n. O\n\nTwenty O\npeople O\nwere O\ninjured O\non O\nWednesday O\nwhen O\nthe O\nEgyptAir B-ORG\nBoeing B-MISC\n707 O\novershot O\nthe O\nrunway O\n, O\ncaught O\nfire O\n, O\nhit O\na O\ntaxi O\nand O\nskipped O\nacross O\na O\nroad O\nonto O\na O\nrailway O\nline O\n. O\n\nChairman O\nMohamed B-PER\nFahim I-PER\nRayyan I-PER\ntold O\na O\nnews O\nconference O\nat O\nCairo B-LOC\nairport O\n: O\n\" O\nThe O\ncontrol O\ntower O\nshould O\nhave O\nallocated O\nthe O\nplane O\nanother O\nrunway O\n, O\ninstead O\nof O\nthe O\none O\nthe O\nplane O\nlanded O\non O\n. O\n\" O\n\n\" O\nThe O\none O\nit O\nlanded O\non O\nis O\n2,250 O\nmetres O\n( O\n2,460 O\nyards O\n) O\nlong O\nwhile O\nthe O\nother O\none O\nif O\nmore O\nthan O\n3,000 O\nmetres O\n( O\n3,300 O\nyards O\n) O\nlong O\nand O\nis O\nless O\nsteep O\n, O\n\" O\nhe O\nadded O\n. O\n\nHe O\nsaid O\na O\nTurkish B-MISC\ncivil O\naviation O\nauthority O\nofficial O\nhad O\nmade O\nthe O\nsame O\npoint O\nand O\nhe O\nnoted O\nthat O\na O\nTurkish B-MISC\nplane O\nhad O\na O\nsimilar O\naccident O\nthere O\nin O\n1994 O\n. O\n\nThe O\nEgyptAir B-ORG\npilot O\nblamed O\nTurkish B-MISC\nairport O\nstaff O\nfor O\nmisleading O\nhim O\n. O\n\nThe O\nlanding O\ntook O\nplace O\nafter O\na O\nrainstorm O\n. O\n\n\" O\nIts O\nnot O\nan O\naccident O\n. O\n\nIt O\n's O\nvery O\nwet O\n. O\n\nThe O\nbrake O\naction O\nis O\nvery O\npoor O\nand O\nthe O\ntower O\nsaid O\nit O\n's O\nmedium O\n. O\n\nThat O\n's O\nwrong O\n, O\n\" O\nthe O\npilot O\ntold O\nprivate O\nIhlas B-ORG\nnews O\nagency O\nin O\nEnglish B-MISC\n. O\n\n-DOCSTART- O\n\nEgypt B-LOC\nwants O\nnothing O\nto O\ndo O\nwith O\nSudanese B-MISC\nrulers O\n. O\n\nCAIRO B-LOC\n1996-08-22 O\n\nThe O\nEgyptian B-MISC\ngovernment O\nwill O\nhave O\nnothing O\nmore O\nto O\ndo O\nwith O\nthe O\nSudanese B-MISC\ngovernment O\nbecause O\nit O\ncontinues O\nto O\nshelter O\nand O\nsupport O\nEgyptian B-MISC\nmilitants O\n, O\nPresident O\nHosni B-PER\nMubarak I-PER\nsaid O\nin O\na O\nspeech O\non O\nThursday O\n. O\n\nEgypt B-LOC\nsays O\nthe O\nSudanese B-MISC\ngovernment O\nhelped O\nthe O\nMoslem B-MISC\nmilitants O\nwho O\ntried O\nto O\nkill O\nMubarak B-PER\nin O\nAddis B-LOC\nAbaba I-LOC\nlast O\nyear O\n. O\n\nIt O\nsponsored O\nlast O\nweek O\n's O\nU.N. B-ORG\nSecurity I-ORG\nCouncil I-ORG\nresolution O\nthreatening O\na O\nban O\non O\nSudanese B-MISC\nflights O\nabroad O\nif O\nKhartoum B-LOC\ndoes O\nnot O\nhand O\nover O\nthree O\nmen O\naccused O\nin O\nthe O\nAddis B-LOC\nAbaba I-LOC\nincident O\n. O\n\nThe O\nsanctions O\nwill O\ncome O\ninto O\neffect O\nin O\nNovember O\nif O\nSudan B-LOC\nfails O\nto O\nextradite O\nthe O\nmen O\n, O\nbut O\nSudan B-LOC\nsays O\nit O\ncannot O\nhand O\nthem O\nover O\nto O\nEthiopia B-LOC\nfor O\ntrial O\nbecause O\nthey O\nare O\nnot O\nin O\nSudan B-LOC\n. O\n\n\" O\nWe O\nare O\nstill O\neager O\nthat O\nnothing O\nshould O\naffect O\nthe O\nSudanese B-MISC\npeople O\nbut O\nwe O\nwill O\nnot O\ndeal O\nwith O\nthe O\ncurrent O\nregime O\nor O\nthe O\nTurabi B-PER\nfront O\nor O\nwhatever O\n, O\n\" O\nMubarak B-PER\ntold O\na O\ngroup O\nof O\nacademics O\n. O\n\nHassan B-PER\nal-Turabi I-PER\nis O\nthe O\nleader O\nof O\nthe O\nNational B-ORG\nIslamic I-ORG\nFront I-ORG\n, O\nthe O\npolitical O\nforce O\nbehind O\nthe O\nSudanese B-MISC\ngovernment O\n. O\n\n\" O\nI O\ndo O\nn't O\nwant O\nto O\ngo O\ninto O\nmore O\ndetails O\nthan O\nthat O\nbut O\nthere O\nare O\nmore O\ndetails O\nand O\nthey O\nare O\nbitter O\n. O\n\nThere O\nare O\nterrorists O\nthey O\nare O\nsheltering O\nand O\nthey O\nmake O\nSudanese B-MISC\npassorts O\nfor O\nthem O\nand O\nthey O\nget O\npaid O\nby O\nthem O\n, O\n\" O\nMubarak B-PER\nsaid O\n. O\n\nHe O\ndid O\nnot O\nsay O\nif O\nEgypt B-LOC\nwould O\ngo O\nso O\nfar O\nas O\nto O\nbreak O\nrelations O\n, O\na O\nstep O\nit O\nhas O\nbeen O\nreluctant O\nto O\ntake O\n, O\nostensibly O\nbecause O\nit O\nwould O\naffect O\nordinary O\nSudanese B-MISC\n. O\n\n-DOCSTART- O\n\nTurkish B-MISC\nshares O\nshed O\ngains O\nin O\nprofit-taking O\n. O\n\nISTANBUL B-LOC\n1996-08-22 O\n\nTurkish B-MISC\nshares O\nended O\nlower O\non O\nThursday O\n, O\nshedding O\ngains O\nof O\nearlier O\nin O\nthe O\nweek O\namid O\nprofit-taking O\nsales O\n, O\nbrokers O\nsaid O\n. O\n\nThe O\nIMKB-100 B-MISC\nlost O\n0.19 O\npercent O\nor O\n123.89 O\npoints O\nto O\nend O\nat O\n64,178.78 O\n. O\n\nGains O\nso O\nfar O\nthis O\nweek O\nhave O\ntotalled O\n2.92 O\npercent O\n. O\n\nDaily O\nvolume O\ndropped O\nto O\n7.2 O\ntrillion O\nlira O\nfrom O\nWednesday O\n's O\n7.8 O\ntrillion O\nlira O\n. O\n\n\" O\nProfit-taking O\nsales O\nin O\nthe O\nafternoon O\nshowed O\nthe O\nlatest O\ngains O\nof O\nthe O\nindex O\nwere O\nactually O\na O\nreaction O\nrise O\n. O\n\nI O\nexpect O\nthe O\nmarket O\nto O\ngo O\nas O\nfar O\ndown O\nas O\n63,000 O\ntomorrow O\nif O\nsales O\ncontinue O\n, O\n\" O\nsaid O\nBurcin B-PER\nMavituna I-PER\nfrom O\nInterbank B-ORG\n. O\n\nBrokers O\nsaid O\nprofit O\ntaking O\nsales O\nhad O\ncome O\nespecially O\nas O\nthe O\nindex O\napproached O\nthe O\n65,000 O\nresistance O\nlevel O\n. O\n\nThey O\nsaid O\nthe O\nindex O\ncould O\nalso O\nrise O\ntowards O\n65,000 O\nif O\nthe O\ncheap O\nshare O\nprices O\nattracted O\nbuyers O\n. O\n\nThe O\nmarket O\nhad O\nits O\nfirst O\nresistance O\nat O\n67,000 O\nif O\nit O\npierced O\n65,000 O\n, O\nthey O\nadded O\n. O\n\nThe O\nsession O\n's O\nmost O\nactive O\nshares O\nwere O\nthose O\nof O\nIsbank B-ORG\ngained O\n300 O\nlira O\nto O\n8,600 O\n. O\n\nShares O\nof O\nutility O\nCukurova B-ORG\nlost O\n3,000 O\nlira O\nto O\n67,000 O\n. O\n\nThe O\n85-share O\nindustrial O\nindex O\nlost O\n0.47 O\npercent O\nto O\n70,848.86 O\nand O\nthe O\n15-share O\nfinancial O\nindex O\nrose O\nby O\n0.55 O\npercent O\nto O\n55,929.89 O\n. O\n\nOf O\nthe O\n218 O\nshares O\ntraded O\n, O\ngainers O\noutdid O\nlosers O\nby O\n100 O\nto O\n64 O\nand O\n54 O\nshares O\nwere O\nstable O\n. O\n\n-- O\nIstanbul B-ORG\nNewsroom I-ORG\n, O\n+90-212-275 O\n0875 O\nSA O\n\n-DOCSTART- O\n\nMiss B-MISC\nUniverse I-MISC\nhides O\nbehind O\nveil O\nof O\nsilence O\n. O\n\nKieran B-PER\nMurray I-PER\n\nLAS B-LOC\nCRUCES I-LOC\n, O\nN.M. O\n1996-08-22 O\n\nMiss B-MISC\nUniverse I-MISC\n, O\nVenezuela B-LOC\n's O\nAlicia B-PER\nMachado I-PER\n, O\nleft O\nNew B-LOC\nMexico I-LOC\non O\nThursday O\n, O\nrefusing O\nto O\nanswer O\nquestions O\nabout O\nher O\nweight O\nor O\nclaims O\nshe O\nwas O\ntold O\nto O\neither O\ngo O\non O\na O\ncrash O\ndiet O\nor O\ngive O\nup O\nher O\ntitle O\n. O\n\nMachado B-PER\n, O\n19 O\n, O\nflew O\nto O\nLos B-LOC\nAngeles I-LOC\nafter O\nslipping O\naway O\nfrom O\nthe O\nNew B-LOC\nMexico I-LOC\ndesert O\ntown O\nof O\nLas B-LOC\nCruces I-LOC\n, O\nwhere O\nshe O\nattended O\nthe O\n1996 B-MISC\nMiss I-MISC\nTeen I-MISC\nUSA I-MISC\npageant O\non O\nWednesday O\n. O\n\nWhile O\nMachado B-PER\nwas O\nnot O\na O\ncontestant O\nhere O\n, O\nshe O\ncame O\nunder O\nintense O\nscrutiny O\nfollowing O\nreports O\nshe O\nwas O\ngiven O\nan O\nultimatum O\nby O\nLos B-MISC\nAngeles-based I-MISC\nMiss B-ORG\nUniverse I-ORG\nInc. I-ORG\nto O\ndrop O\n27 O\npounds O\n( O\n12 O\nkg O\n) O\nin O\ntwo O\nweeks O\nor O\nrisk O\nlosing O\nher O\ncrown O\n. O\n\nIn O\nVenezuela B-LOC\n, O\nher O\nmother O\ntold O\nReuters B-ORG\nthat O\nMachado B-PER\nhad O\na O\nswollen O\nface O\nwhen O\nshe O\nleft O\nhome O\ntwo O\nweeks O\nago O\nbecause O\nshe O\nhad O\nher O\nwisdom O\nteeth O\nextracted O\n. O\n\nMarta B-PER\nFajardo I-PER\ninsisted O\nher O\ndaughter O\n, O\nwho O\nweighed O\n112 O\npounds O\n( O\n51 O\nkg O\n) O\nwhen O\nshe O\nwon O\nthe O\nMiss B-MISC\nUniverse I-MISC\ntitle O\nin O\nLas B-LOC\nVegas I-LOC\nin O\nMay O\n, O\nhad O\nperfectly O\nnormal O\neating O\nhabits O\n. O\n\n\" O\nEverybody O\nhas O\ntheir O\nown O\naddiction O\nto O\nsomething O\nor O\nother O\nbut O\nit O\n's O\nnot O\nas O\nif O\nshe O\neats O\ncakes O\nlike O\ncrazy O\n, O\n\" O\nshe O\nsaid O\n. O\n\nOrganisers O\nflatly O\ndenied O\never O\nthreatening O\nMachado B-PER\nbut O\nimmediately O\nput O\nher O\nunder O\nwraps O\nand O\nblocked O\naccess O\nto O\nher O\n. O\n\nDressed O\nin O\na O\nblack O\nstrapless O\nevening O\ngown O\nat O\nWednesday O\n's O\npageant O\n, O\nMachado B-PER\nwas O\nclearly O\nheavier O\nthan O\nthe O\ncontestants O\nbut O\nstill O\nwon O\nrave O\nreviews O\nafter O\nher O\nbrief O\nappearance O\non O\nstage O\n. O\n\n\" O\nAre O\nyou O\nkidding O\n? O\n\nShe O\n's O\nfantastic O\n, O\n\" O\nsaid O\nNikki B-PER\nCampbell I-PER\n, O\n28 O\n, O\nwho O\nwent O\nto O\nthe O\npageant O\n. O\n\" O\n\nShe O\nlooked O\ngreat O\n. O\n\nVery O\nsexy O\n. O\n\" O\n\nMachado B-PER\n's O\npublicists O\nsaid O\non O\nThursday O\nshe O\nwas O\nscheduled O\nto O\nstay O\nin O\nLos B-LOC\nAngeles I-LOC\nfor O\npromotional O\nwork O\nwith O\nsponsors O\nbefore O\nreturning O\nto O\nVenezuela B-LOC\non O\nSept O\n. O\n\n5 O\n. O\n\nBeauty O\nqueens O\nare O\nhigh-profile O\npersonalities O\nin O\nVenezuela B-LOC\nand O\nMachado B-PER\n's O\nalleged O\nweight O\nproblem O\nmade O\nfront O\npage O\nnews O\nthis O\nweek O\n. O\n\nIt O\nwas O\nan O\nofficial O\nof O\nthe O\nMiss B-ORG\nVenezuela I-ORG\nOrganisation I-ORG\nwho O\nfirst O\nsaid O\nMachado B-PER\nhad O\nbeen O\ntold O\nto O\nlose O\nweight O\nfast O\n. O\n\nPeople O\nclose O\nto O\nher O\nsaid O\nshe O\nthen O\neased O\nup O\non O\nher O\ndiet O\nand O\nindulged O\nher O\npassion O\nfor O\npasta O\nand O\ncake O\n, O\nbut O\nit O\nwas O\nnot O\nclear O\nhow O\nmany O\npounds O\nshe O\ngained O\nand O\nmost O\npeople O\nwho O\nsaw O\nher O\nsaid O\nshe O\nwas O\nstill O\na O\nlong O\nway O\nfrom O\nbeing O\nfat O\n. O\n\nMartin B-PER\nBrooks I-PER\n, O\npresident O\nof O\nMiss B-ORG\nUniverse I-ORG\nInc I-ORG\n, O\nsaid O\nhe O\nspoke O\nwith O\nMachado B-PER\nto O\nassure O\nher O\nthat O\norganisers O\nwere O\nnot O\nputting O\npressure O\non O\nher O\n. O\n\n\" O\nShe O\n's O\nfine O\nwith O\nit O\n. O\n\nShe O\nwished O\n, O\nas O\nwe O\nall O\ndid O\n, O\nthat O\nit O\nhad O\nn't O\nhappened O\nbut O\nshe O\n's O\nspiritually O\nand O\nmentally O\nterrific O\n. O\n\nThere O\n's O\nno O\nproblem O\nwhatsoever O\n, O\n\" O\nhe O\ntold O\nReuters B-ORG\n. O\n\nHe O\nsaid O\nthe O\nlifestyle O\nassociated O\nwith O\nbeing O\nMiss B-MISC\nUniverse I-MISC\ncould O\nmake O\nroutine O\nexercise O\ndifficult O\n. O\n\n\" O\nThe O\nproblem O\nis O\nthey O\ntravel O\nso O\nmuch O\nand O\nare O\nso O\nbusy O\nthat O\nthe O\nability O\nto O\nhave O\nany O\ntype O\nof O\nregimented O\nroutine O\nworkout O\ndoes O\nn't O\nexist O\n. O\n\nI O\ndont O\nknow O\nif O\nAlicia B-PER\nis O\nworking O\nout O\n. O\n\nWe O\nhave O\nn't O\ntalked O\nabout O\nit O\nbecause O\nit O\nhas O\nn't O\nbeen O\nan O\nissue O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nKevorkian B-PER\nattends O\nthird O\nsuicide O\nin O\nweek O\n. O\n\nPONTIAC B-LOC\n, O\nMich B-LOC\n. O\n\n1996-08-22 O\n\nDr. O\nJack B-PER\nKevorkian I-PER\nattended O\nhis O\nthird O\nsuicide O\nin O\nless O\nthan O\na O\nweek O\non O\nThursday O\n, O\nbringing O\nthe O\nbody O\nof O\na O\n40-year-old O\nMissouri B-LOC\nwoman O\nsuffering O\nfrom O\nmultiple O\nsclerosis O\nto O\na O\nhospital O\nemergency O\nroom O\n, O\ndoctors O\nsaid O\n. O\n\nDr O\nRobert B-PER\nAranosian I-PER\n, O\nemergency O\nroom O\ndirector O\nat O\nPontiac B-LOC\nOsteopathic I-LOC\nHospital I-LOC\n, O\nsaid O\nKevorkian B-PER\nbrought O\nin O\nthe O\nbody O\nof O\nPatricia B-PER\nSmith I-PER\n, O\nof O\nLees B-LOC\nSummit I-LOC\n, O\nMo B-LOC\n. O\n\n, O\nat O\nmidday O\nand O\ntold O\ndoctors O\nthat O\nshe O\nhad O\nbeen O\nparalysed O\nby O\nthe O\ndisease O\n. O\n\nIt O\nwas O\nhis O\nsecond O\nassisted-suicide O\nin O\n36 O\nhours O\nand O\nthe O\n37th O\nthat O\nhe O\nhas O\nacknowledged O\nattending O\nsince O\nstarting O\nhis O\ncrusade O\nfor O\ndoctor O\nassisted O\nsuicide O\nin O\n1990 O\n. O\n\nKevorkian B-PER\n's O\nlawyer O\n, O\nGeoffrey B-PER\nFieger I-PER\n, O\nsaid O\nthose O\nattending O\nSmith B-PER\n's O\ndeath O\nincluded O\nher O\nhusband O\n, O\nDavid B-PER\n, O\na O\npolice O\nofficer O\n, O\nher O\nfather O\n, O\nJames B-PER\nPoland I-PER\n, O\nand O\nKevorkian B-PER\n. O\n\nIt O\nwas O\nthe O\nfirst O\nknown O\ntime O\nthat O\na O\npolice O\nofficer O\nhas O\nbeen O\npresident O\nat O\nthe O\nsuicide O\nof O\none O\nof O\nKevorkian B-PER\n's O\npatients O\n. O\n\nHe O\noffered O\nno O\ndetails O\nabout O\nthe O\ncause O\nof O\nSmith B-PER\n's O\ndeath O\nor O\nthe O\nlocation O\n. O\n\nShe O\nwas O\na O\nnurse O\nwho O\nhad O\n\" O\nrapidly O\nprogressing O\nmultple O\nsclerosis O\n. O\n\" O\n\nOn O\nTuesday O\nnight O\n, O\nKevorkian B-PER\nattended O\nthe O\ndeath O\nof O\nLouise B-PER\nSiebens I-PER\n, O\na O\n76-year-old O\nTexas B-LOC\nwoman O\nwith O\namyotrophic O\nlateral O\nsclerosis O\n, O\nor O\nLou B-PER\nGehrig I-PER\n's O\ndisease O\n. O\n\nOn O\nAugust O\n15 O\n, O\nKevorkian B-PER\nhelped O\nJudith B-PER\nCurren I-PER\n, O\na O\n42-year-old O\nMassachusetts B-LOC\nnurse O\n, O\nwho O\nsuffered O\nfrom O\nchronic O\nfatigue O\nsyndrome O\n, O\na O\nnon-terminal O\nillness O\n, O\nto O\nend O\nher O\nlife O\n. O\n\n-DOCSTART- O\n\nFairview B-LOC\n, O\nTexas B-LOC\n, O\n$ O\n1.82 O\nmillion O\ndeal O\nBaa1 O\n- O\nMoody B-ORG\n's I-ORG\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-22 O\n\nMoody B-ORG\n's I-ORG\nInvestors I-ORG\nService I-ORG\n- O\n\nRating O\nAnnouncement O\nAs O\nof O\n08/21/96 O\n. O\n\nIssuer O\n: O\nFairview B-LOC\nTown I-LOC\n\nState O\n: O\nTX B-LOC\n\nRating O\n: O\nBaa1 O\n\nSale O\nAmount O\n: O\n1,820,000 O\n\nExpected O\nSale O\nDate O\n: O\n08/27/96 O\n\n-- O\nU.S. B-ORG\nMunicipal I-ORG\nDesk I-ORG\n, O\n212-859-1650 O\n\n-DOCSTART- O\n\nDefiant O\nU.S. B-LOC\nneo-Nazi B-MISC\njailed O\nby O\nGerman B-MISC\ncourt O\n. O\n\nAndrew B-PER\nGray I-PER\n\nHAMBURG B-LOC\n, O\nGermany B-LOC\n1996-08-22 O\n\nA O\nHamburg B-LOC\ncourt O\nsentenced O\nU.S. B-LOC\nneo-Nazi B-MISC\nleader O\nGary B-PER\nLauck I-PER\non O\nThursday O\nto O\nfour O\nyears O\nin O\nprison O\nfor O\npumping O\nbanned O\nextremist O\npropaganda O\ninto O\nGermany B-LOC\nfrom O\nhis O\nbase O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\nLauck B-PER\n, O\nfrom O\nLincoln B-LOC\n, O\nNebraska B-LOC\n, O\nyelled O\na O\ntirade O\nof O\nabuse O\nat O\nthe O\ncourt O\nafter O\nhis O\nconviction O\nfor O\ninciting O\nracial O\nhatred O\n. O\n\n\" O\nThe O\nstruggle O\nwill O\ngo O\non O\n, O\n\" O\nthe O\n43-year-old O\nshouted O\nin O\nGerman B-MISC\nbefore O\nbeing O\nescorted O\nout O\nby O\nsecurity O\nguards O\n. O\n\nLauck B-PER\n's O\nlawyer O\nvowed O\nhe O\nwould O\nappeal O\nagainst O\nthe O\ncourt O\n's O\ndecision O\n, O\narguing O\nthat O\nhis O\nclient O\nshould O\nhave O\nbeen O\nset O\nfree O\nbecause O\nhe O\nhad O\nnot O\ncommitted O\nany O\noffence O\nunder O\nGerman B-MISC\nlaw O\n. O\n\nThe O\nGerman B-MISC\ngovernment O\nhailed O\nthe O\nconviction O\nas O\na O\nmajor O\nvictory O\nin O\nthe O\nfight O\nagainst O\nneo-Nazism B-MISC\n. O\n\nLauck B-PER\n's O\nworldwide O\nnetwork O\nhas O\nbeen O\nthe O\nmain O\nsource O\nof O\nanti-Semitic B-MISC\npropaganda O\nmaterial O\nflowing O\ninto O\nGermany B-LOC\nsince O\nthe O\n1970s O\n. O\n\n\" O\nLauck B-PER\npossessed O\na O\nwell-oiled O\npropaganda O\nmachine O\n, O\nhoned O\nduring O\nmore O\nthan O\n20 O\nyears O\n, O\n\" O\npresiding O\njudge O\nGuenter B-PER\nBertram I-PER\ntold O\nthe O\ncourt O\n. O\n\n\" O\nHe O\nset O\nup O\na O\npropaganda O\ncannon O\nand O\nfired O\nit O\nat O\nGermany B-LOC\n. O\n\" O\n\nsaid O\nBertram B-PER\n, O\nwho O\nalso O\nread O\nout O\nextracts O\nfrom O\nLauck B-PER\n's O\nmaterial O\npraising O\nHitler B-PER\nas O\n\" O\nthe O\ngreatest O\nof O\nall O\nleaders O\n\" O\nand O\ndescribing O\nthe O\nNazi B-MISC\nslaughter O\nof O\nmillions O\nof O\nJews B-MISC\nas O\na O\nmyth O\n. O\n\nEager O\nto O\nput O\nLauck B-PER\nbehind O\nbars O\nquickly O\nand O\navoid O\na O\nlong O\nand O\ncomplex O\ntrial O\n, O\nprosecutor O\nBernd B-PER\nMauruschat I-PER\nlimited O\nhis O\ncharges O\nto O\noffences O\nsince O\n1994 O\n. O\n\nHe O\nhad O\ndemanded O\na O\nfive-year O\njail O\nterm O\nbut O\nsaid O\nhe O\nwas O\nsatisfied O\nwith O\nthe O\ncourt O\n's O\nsentence O\n. O\n\nPublishing O\nand O\ndistributing O\nneo-Nazi B-MISC\nmaterial O\nis O\nillegal O\nin O\nGermany B-LOC\nbut O\nLauck B-PER\n's O\ndefence O\nteam O\nhad O\nargued O\nthat O\nU.S B-LOC\nfreedom O\nof O\nspeech O\nlaws O\nmeant O\nhe O\nwas O\nfree O\nto O\nproduce O\nhis O\nswastika-covered O\nbooks O\n, O\nmagazines O\n, O\nvideos O\nand O\nflags O\nin O\nhis O\nhomeland O\n. O\n\nInterior O\nMinister O\nManfred B-PER\nKanther I-PER\nsaid O\nin O\na O\nstatement O\nhe O\n\" O\nwelcomed O\nthe O\nprosecution O\nand O\nconviction O\nof O\none O\nof O\nthe O\nringleaders O\nof O\ninternational O\nneo-Nazism B-MISC\nand O\nbiggest O\ndistributers O\nof O\nvicious O\nracist O\npublications O\n\" O\n. O\n\n\" O\nIt O\nis O\nhigh O\ntime O\nhe O\nwas O\nbehind O\nbars O\n, O\n\" O\nthe O\nopposition O\nSocial B-MISC\nDemocrats I-MISC\nsaid O\nin O\na O\nstatement O\n. O\n\nLauck B-PER\n, O\ndressed O\nin O\na O\nsober O\nblue O\nsuit O\nand O\nsporting O\nhis O\ntrademark O\nHitleresque B-MISC\nblack O\nmoustache O\n, O\nshowed O\nno O\nsign O\nof O\nemotion O\nas O\nBertram B-PER\nspent O\nmore O\nthan O\nan O\nhour O\nreading O\nout O\nthe O\nverdict O\nand O\nexplaining O\nthe O\ncourt O\n's O\ndecision O\n. O\n\nBut O\nas O\nLauck B-PER\nwas O\nabout O\nto O\nbe O\nled O\naway O\n, O\nhe O\nturned O\nto O\nreporters O\nand O\nblurted O\nout O\na O\nvirtually O\nincomprehensible O\nquick-fire O\ndiatribe O\nagainst O\nthe O\ncourt O\n. O\n\n\" O\nNeither O\nthe O\nNational B-MISC\nSocialists I-MISC\n( O\nNazis B-MISC\n) O\nnor O\nthe O\ncommunists O\ndared O\nto O\nkidnap O\nan O\nAmerican B-MISC\ncitizen O\n, O\n\" O\nhe O\nshouted O\n, O\nin O\nan O\noblique O\nreference O\nto O\nhis O\nextradition O\nto O\nGermany B-LOC\nfrom O\nDenmark B-LOC\n. O\n\" O\n\nThat O\n's O\nthe O\ntruth O\n. O\n\" O\n\nHis O\nattorney O\n, O\nHans-Otto B-PER\nSieg I-PER\n, O\ntold O\nreporters O\noutside O\nthe O\ncourtroom O\nthat O\nthe O\njudges O\nhad O\nnot O\nexplained O\nhow O\na O\nGerman B-MISC\ncourt O\ncould O\njudge O\nsomeone O\nfor O\nactions O\ncarried O\nout O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\nBertram B-PER\nsaid O\nLauck B-PER\nwas O\nobsessed O\nby O\nNazism B-MISC\nand O\ndevoted O\nhis O\nlife O\nto O\nleading O\nhis O\nNational B-ORG\nSocialist I-ORG\nGerman I-ORG\nWorkers I-ORG\n' I-ORG\nParty I-ORG\nForeign I-ORG\nOrganisation I-ORG\n( O\nNSDAP-AO B-ORG\n) O\n, O\nwhich O\nderives O\nits O\nname O\nfrom O\nthe O\nfull O\nGerman B-MISC\ntitle O\nof O\nHitler B-PER\n's O\nNazi B-MISC\nparty O\n. O\n\nDuring O\nthe O\nthree-month O\ntrial O\n, O\nthe O\ncourt O\ndealt O\nmainly O\nwith O\nissues O\nof O\nthe O\nNSDAP-AO B-ORG\n's O\n\" O\nNS B-ORG\nKampfruf I-ORG\n\" O\n( O\n\" O\nNational B-ORG\nSocialist I-ORG\nBattle I-ORG\nCry I-ORG\n\" O\n) O\nmagazine O\n, O\nfilled O\nwith O\nreferences O\nto O\nAryan B-MISC\nsupremacy O\nand O\ndefamatory O\nstatements O\nabout O\nJews B-MISC\n. O\n\nThe O\ncourt O\nrejected O\nSieg B-PER\n's O\nargument O\nthat O\nLauck B-PER\n's O\nextradition O\nfrom O\nDenmark B-LOC\n, O\nwhere O\nhe O\nwas O\narrested O\nin O\nMarch O\nlast O\nyear O\nat O\nthe O\nrequest O\nof O\nGerman B-MISC\nauthorities O\n, O\nwas O\nillegal O\n. O\n\nLauck B-PER\nwas O\nalso O\nconvicted O\nof O\ndisseminating O\nthe O\nsymbols O\nof O\nanti-constitutional O\norganisations O\n. O\n\nHe O\nwill O\nprobably O\nbe O\nfree O\nin O\naround O\ntwo O\nand O\na O\nhalf O\nyears O\n. O\n\nThe O\ncourt O\nruled O\nthat O\nthe O\n15 O\nmonths O\nhe O\nhas O\nspent O\nin O\ncustody O\nsince O\nhis O\narrest O\nshould O\nbe O\nsubtracted O\nfrom O\nhis O\nprison O\nterm O\n. O\n\n-DOCSTART- O\n\nUN B-ORG\nofficial O\nsays O\nIraqi B-MISC\ndeal O\nwill O\noccur O\n\" O\nsoon O\n\" O\n. O\n\nUNITED B-ORG\nNATIONS I-ORG\n1996-08-22 O\n\nA O\nsenior O\nU.N. B-ORG\nofficial O\nsaid O\non O\nThursday O\nhe O\nexpected O\narrangements O\nto O\nimplement O\nthe O\nIraqi B-MISC\noil-for-food O\ndeal O\ncould O\nbe O\ncompleted O\n\" O\nquite O\nsoon O\n. O\n\" O\n\n\" O\nI O\nam O\nreluctant O\nto O\nspeculate O\nbut O\nwe O\nare O\ndoing O\nthe O\npreparations O\nand O\nthe O\nsecretary-general O\nis O\nanxious O\nto O\nstart O\nthe O\nprogram O\n, O\n\" O\nsaid O\nUndersecretary-General O\nYasushi B-PER\nAkashi I-PER\n. O\n\n\" O\nIt O\nmight O\nbe O\nsooner O\nthan O\nyou O\nthink O\n, O\n\" O\nhe O\ntold O\nreporters O\nafter O\nbriefing O\nthe O\nSecurity B-ORG\nCouncil I-ORG\non O\narrangements O\nfor O\nmonitors O\nneeded O\nto O\ncarry O\nout O\nthe O\nagreement O\n. O\n\nAkashi B-PER\nis O\nhead O\nof O\nthe O\nDepartment B-ORG\nof I-ORG\nHumanitarian I-ORG\naffairs I-ORG\n. O\n\nHis O\ndeputy O\nearlier O\nspeculated O\nat O\nleast O\n10 O\ndays O\n. O\n\n-DOCSTART- O\n\nSuspected O\nkillers O\nof O\nbishop O\ndead O\n-- O\nAlgeria B-ORG\nTV I-ORG\n. O\n\nPARIS B-LOC\n1996-08-22 O\n\nAlgerian B-MISC\nsecurity O\nforces O\nhave O\nshot O\ndead O\nthree O\nMoslem B-MISC\nguerrillas O\nsuspected O\nof O\nkilling O\na O\nleading O\nFrench B-MISC\nbishop O\nin O\nwestern O\nAlgeria B-LOC\n, O\nthe O\nAlgerian B-MISC\nstate-run O\ntelevision O\nsaid O\non O\nThursday O\n. O\n\nSecurity O\nforces O\nalso O\narrested O\nfour O\nother O\nmen O\nsought O\nfor O\ngiving O\nsupport O\nto O\nthe O\nslain O\nMoslem B-MISC\nrebels O\n, O\nthe O\ntelevision O\nsaid O\n. O\n\nThe O\ntelevision O\n, O\nwhich O\ndid O\nnot O\nsay O\nwhen O\nthe O\nsecurity O\nforces O\nkilled O\nthe O\nrebels O\n, O\nsaid O\nthe O\nfour O\narrested O\nmen O\nconfessed O\ndetails O\nof O\nthe O\nassassination O\nof O\nthe O\nFrench B-MISC\nRoman B-MISC\nCatholic I-MISC\nBishop O\nPierre B-PER\nClaverie I-PER\n. O\n\nThe O\n58-year-old O\nClaverie B-PER\nwas O\nkilled O\nin O\nAugust O\n1 O\nin O\na O\nbomb O\nblast O\nat O\nhis O\nresidence O\nin O\nthe O\nwestern O\nAlgerian B-MISC\ncity O\nof O\nOran B-LOC\n, O\nhours O\nafter O\nhe O\nmet O\nvisiting O\nFrench B-MISC\nForeign O\nMinister O\nHerve B-PER\nde I-PER\nCharette I-PER\nin O\nAlgiers B-LOC\n. O\n\nAn O\nestimated O\n50,000 O\nAlgerians B-MISC\nand O\nmore O\nthan O\n110 O\nforeigners O\nhave O\nbeen O\nkilled O\nin O\nAlgeria B-LOC\n's O\nviolence O\npitting O\nMoslem B-MISC\nrebels O\nagainst O\nthe O\nAlgerian B-MISC\ngovernment O\nforces O\nsince O\nearly O\n1992 O\n, O\nwhen O\nthe O\nauthorities O\ncancelled O\na O\ngeneral O\nelection O\nin O\nwhich O\nradical O\nIslamists B-MISC\ntook O\na O\ncommanding O\nlead O\n. O\n\n-DOCSTART- O\n\nGerman B-MISC\nflown O\ncargo O\nJanuary-July O\nrise O\n3.8 O\npercent O\n. O\n\nFRANKFURT B-LOC\n1996-08-22 O\n\nThe O\nfollowing O\ntable O\nshows O\ntotal O\nflown O\nair O\ncargo O\nvolumes O\nin O\ntonnes O\nhandled O\nat O\ninternational O\nGerman B-MISC\nairports O\nJanuary-July O\n1996 O\n. O\n\nThe O\nfigures O\nexclude O\ntrucked O\nairfreight O\naccording O\nto O\nthe O\nGerman B-MISC\nairports O\nassociation O\nADV B-ORG\n. O\n\nBerlin B-LOC\n( O\ntotal O\n) O\n17,844 O\nup O\n5.9 O\npct O\n\n- O\nTegel B-LOC\n10,896 O\nup O\n3.1 O\n\n- O\nTempelhof B-LOC\n202 O\ndown O\n60.0 O\n\n- O\nSchoenefeld B-LOC\n6,746 O\nup O\n16.8 O\n\nBremen B-LOC\n1,453 O\nup O\n13.1 O\n\nDresden B-LOC\n792 O\nup O\n11.4 O\n\nDuessseldorf B-LOC\n31,347 O\ndown O\n4.4 O\n\nFrankfurt B-LOC\n768,269 O\nup O\n1.5 O\n\nHamburg B-LOC\n21,240 O\ndown O\n3.5 O\n\nHannover B-LOC\n6,030 O\nup O\n15.3 O\n\nKoeln B-LOC\n( O\nCologne B-LOC\n) O\n182,887 O\nup O\n11.8 O\n\nLeipzig B-LOC\n/ O\nHalle B-LOC\n1,806 O\nup O\n45.6 O\n\nMunich B-LOC\n44,525 O\nup O\n11.8 O\n\nMuenster B-LOC\n/ O\nOsnabrueck B-LOC\n382 O\nup O\n28.2 O\n\nNuremberg B-LOC\n25,929 O\nup O\n17.8 O\n\nSaarbruecken B-LOC\n626 O\nup O\n28.3 O\n\nStuttgart B-LOC\n10,655 O\nup O\n11.7 O\n\nTOTAL O\n1,113,785 O\nup O\n3.8 O\n\n- O\nAir B-ORG\nCargo I-ORG\nNewsroom I-ORG\nTel+44 O\n161 O\n542 O\n7706 O\nFax+44 O\n171 O\n542 O\n5017 O\n\n-DOCSTART- O\n\nParibas B-ORG\nrepeats O\nbuy O\non O\nAegon B-ORG\nafter O\nresults O\n. O\n\nAMSTERDAM B-LOC\n1996-08-22 O\n\nSummary O\nof O\nAug O\n22 O\nresearch O\n. O\n\nCompany-------------Price---Broker---------------- O\n\nAegon B-ORG\n83.40 O\nParibas B-ORG\n\nCOMMENT O\n: O\n\" O\nNot O\nonly O\ndid O\nAegon B-ORG\nsurprise O\nwith O\nearnings O\nof O\n711 O\nmillion O\nguilders O\n, O\nwhich O\nwere O\nabove O\nthe O\ntop O\nof O\nthe O\nexpected O\nrange O\n, O\nit O\nalso O\nforecast O\na O\nsimilar O\nperformance O\nin O\nthe O\nsecond O\nhalf O\n. O\n\" O\n\nReiterates O\nprevious O\n\" O\nbuy O\n\" O\nrecommendation O\nafter O\nresults O\n. O\n\nEstimates O\n( O\nDfl B-MISC\n) O\n: O\nEPS O\nP O\n/ O\nE O\nDividend O\n\n1996 O\n5.83 O\n13.8 O\n2.75 O\n\n1997 O\n6.59 O\n12.2 O\n3.10 O\n\n-- O\nAmsterdam B-LOC\nnewsroom O\n, O\n+31 O\n20 O\n504 O\n5000 O\n( O\nFax O\n+31 O\n20 O\n504 O\n5040 O\n) O\n\n-DOCSTART- O\n\nClinton B-PER\n's O\nBallybunion B-ORG\nfans O\ninvited O\nto O\nChicago B-LOC\n. O\n\nDUBLIN B-LOC\n1996-08-22 O\n\nU.S. B-LOC\nPresident O\nBill B-PER\nClinton I-PER\nhad O\nto O\ndrop O\nthe O\nresort O\nof O\nBallybunion B-ORG\nfrom O\na O\nwhirlwind O\nIrish B-MISC\ntour O\nlast O\nyear O\n. O\n\nSo O\nBallybunion B-ORG\nis O\ngoing O\nto O\nAmerica B-LOC\ninstead O\n. O\n\nTwo O\nresidents O\nof O\nthe O\nAtlantic B-LOC\nresort O\n, O\nwhere O\nClinton B-PER\nwas O\nto O\nhave O\nplayed O\ngolf O\nwith O\nthe O\nIrish B-MISC\nForeign O\nMinister O\nDick B-PER\nSpring I-PER\n, O\nhave O\nbeen O\ninvited O\nto O\nthe O\nDemocratic B-MISC\nparty O\nconvention O\nin O\nChicago B-LOC\non O\nAugust O\n26-29 O\n. O\n\nThey O\nhave O\nbeen O\nasked O\nto O\nbring O\nwith O\nthem O\nthe O\nplacards O\nthey O\nwaved O\nwhen O\nClinton B-PER\naddressed O\nIreland B-LOC\nat O\na O\npacked O\nceremony O\nin O\nDublin B-LOC\ncity O\ncentre O\non O\nDecember O\n1 O\n, O\nlast O\nyear O\n. O\n\nThey O\nread O\n: O\n\" O\nBallybunion B-ORG\nbacks O\nClinton B-PER\n. O\n\" O\n\n\" O\nThe O\nDemocratic B-MISC\nparty O\nhave O\nrequested O\nwe O\nbring O\nour O\nplacards O\nwith O\nus O\n. O\n\nWe O\nwill O\nbe O\nguests O\nof O\nthe O\nKennedys B-PER\n, O\n\" O\nsaid O\nFrank B-PER\nQuilter I-PER\n, O\none O\nof O\nthe O\ntwo O\nwho O\nhave O\nbeen O\ninvited O\nto O\nChicago B-LOC\n. O\n\nClinton B-PER\nmade O\na O\ntriumphant O\nIrish B-MISC\ntour O\nto O\nback O\na O\nNorthern B-LOC\nIreland I-LOC\npeace O\nprocess O\nbut O\nwas O\nforced O\nto O\ndrop O\nBallybunion B-ORG\nfrom O\na O\npacked O\nschedule O\nat O\nthe O\nlast O\nminute O\n. O\n\n-DOCSTART- O\n\nBonn B-LOC\nsays O\nMoscow B-LOC\nhas O\npromised O\nto O\nobserve O\nceasefire O\n. O\n\nBONN B-LOC\n1996-08-22 O\n\nGermany B-LOC\nsaid O\non O\nThursday O\nit O\nhad O\nreceived O\nassurances O\nfrom O\nthe O\nRussian B-MISC\ngovernment O\nthat O\nits O\nforces O\nwould O\nobserve O\nthe O\nlatest O\nceasefire O\nin O\nChechnya B-LOC\n. O\n\nForeign B-ORG\nMinistry I-ORG\nspokesman O\nMartin B-PER\nErdmann I-PER\nsaid O\ntop O\nBonn B-LOC\ndiplomat O\nWolfgang B-PER\nIschinger I-PER\nhad O\nbeen O\nassured O\nby O\nsenior O\nRussian B-MISC\nofficials O\nthat O\nthe O\nultimatum O\nto O\nstorm O\nand O\ntake O\nthe O\nChechen B-MISC\ncapital O\nof O\nGrozny B-LOC\nwas O\nnot O\nvalid O\n. O\n\n\" O\nThe O\nRussian B-MISC\nside O\nconfirmed O\nthat O\nthe O\nceasefire O\nis O\nin O\nplace O\nand O\nthey O\nwill O\nkeep O\nto O\nit O\n, O\n\" O\nErdmann B-PER\ntold O\nReuters B-ORG\nafter O\nspeaking O\nby O\ntelephone O\nto O\nIschinger B-PER\n, O\nwho O\nhad O\nmet O\nthe O\nofficials O\non O\na O\ntwo-day O\nvisit O\nto O\nMoscow B-LOC\n. O\n\nHe O\nreturned O\nto O\nBonn B-LOC\non O\nThursday O\n. O\n\nIschinger B-PER\nis O\nthe O\npolitical O\ndirector O\nof O\nBonn B-LOC\n's O\nforeign O\nministry O\n. O\n\nIschinger B-PER\nsaid O\nhe O\nmet O\nthree O\nRussian B-MISC\ndeputy O\nforeign O\nministers O\nand O\na O\nvice O\ndefence O\nminister O\n, O\nwho O\nconfirmed O\nRussian B-MISC\nForeign O\nMinister O\nYevgeny B-PER\nPrimakov I-PER\n's O\npledge O\nthat O\nMoscow B-LOC\nwould O\nseek O\na O\npolitical O\nsolution O\nunder O\nthe O\naegis O\nof O\nthe O\nOrganisation B-ORG\nfor I-ORG\nSecurity I-ORG\nand I-ORG\nCooperation I-ORG\nin I-ORG\nEurope I-ORG\n( O\nOSCE B-ORG\n) O\n. O\n\n\" O\nThe O\nultimatum O\n( O\nto O\nstorm O\nGrozny B-LOC\n) O\nis O\nno O\nlonger O\nan O\nissue O\n, O\n\" O\nhe O\nsaid O\nquoting O\nIschinger B-PER\n, O\nwho O\nhad O\nbeen O\nsent O\nto O\nMoscow B-LOC\nby O\nGerman B-MISC\nForeign O\nMinister O\nKlaus B-PER\nKinkel I-PER\nas O\nhis O\npersonal O\nenvoy O\nto O\nurge O\nan O\nend O\nto O\nMoscow B-LOC\n's O\nmilitary O\ncampaign O\nin O\nthe O\nbreakaway O\nregion O\n. O\n\nIschinger B-PER\nsaid O\nthe O\nthreat O\nof O\na O\nmajor O\nassault O\nto O\ntake O\nGrozny B-LOC\nhad O\nbeen O\nthe O\nunauthorised O\ninitiative O\nof O\nthe O\ncommanding O\ngeneral O\nand O\nnot O\nMoscow B-LOC\n's O\nintention O\n. O\n\nThe O\nofficials O\nhad O\nbeen O\npositive O\nabout O\nKinkel B-PER\n's O\nrequest O\non O\nWednesday O\nthat O\nPresident O\nBoris B-PER\nYeltsin I-PER\n's O\nsecurity O\nchief O\nAlexander B-PER\nLebed I-PER\nshould O\n, O\non O\nhis O\nreturn O\nto O\nMoscow B-LOC\n, O\nmeet O\nTim B-PER\nGoldiman I-PER\n, O\nthe O\nOSCE B-ORG\nrepresentative O\nresponsible O\nfor O\nChechnya B-LOC\n, O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nIndia B-LOC\nsays O\nsees O\nno O\narms O\nrace O\nwith O\nChina B-LOC\n, O\nPakistan B-LOC\n. O\n\nNEW B-LOC\nDELHI I-LOC\n1996-08-22 O\n\nIndia B-LOC\nsaid O\non O\nThursday O\nthat O\nits O\nopposition O\nto O\na O\nglobal O\nnuclear O\ntest O\nban O\ntreaty O\ndid O\nnot O\nmean O\nNew B-LOC\nDelhi I-LOC\nintended O\nto O\nenter O\ninto O\nan O\narms O\nrace O\nwith O\nneighbouring O\nPakistan B-LOC\nand O\nChina B-LOC\n. O\n\nForeign O\nMinister O\nI.K. B-PER\nGujral I-PER\nwas O\nasked O\nat O\na O\nnews O\nconference O\nif O\nIndia B-LOC\n's O\ndecision O\nto O\nblock O\nadoption O\nof O\nthe O\naccord O\nin O\nGeneva B-LOC\nwould O\nlead O\nto O\nan O\narms O\nrace O\nwith O\nPakistan B-LOC\nand O\nChina B-LOC\n. O\n\n\" O\nI O\ndo O\nn't O\nsee O\nthat O\npossibility O\nbecause O\nIndia B-LOC\nis O\nnot O\nentering O\ninto O\nany O\narms O\nrace O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nOur O\nnot O\nsigning O\na O\nnew O\ntreaty O\ndoes O\nnot O\nmean O\nwe O\nare O\ngoing O\nin O\nfor O\nany O\nnew O\nkind O\nof O\nweapons O\n, O\nparticularly O\nnuclear O\n. O\n\" O\n\nChina B-LOC\n, O\nalong O\nwith O\nBritain B-LOC\n, O\nFrance B-LOC\n, O\nRussia B-LOC\nand O\nthe O\nUnited B-LOC\nStates I-LOC\n, O\nis O\na O\ndeclared O\nnuclear O\npower O\n. O\n\nIndia B-LOC\ncarried O\nout O\na O\nnuclear O\ntest O\nin O\n1974 O\nbut O\nsays O\nit O\nhas O\nnot O\nbuilt O\nthe O\nbomb O\n. O\n\nExperts O\nbelieve O\nboth O\nIndia B-LOC\nand O\nPakistan B-LOC\ncould O\nquickly O\nassemble O\nnuclear O\nweapons O\n. O\n\nGujral B-PER\nsaid O\nhe O\ndid O\nnot O\nexpect O\nIndia B-LOC\n's O\nveto O\nof O\nthe O\nComprehensive B-MISC\nTest I-MISC\nBan I-MISC\nTreaty I-MISC\n( O\nCTBT B-MISC\n) O\nto O\ndamage O\nbilateral O\nties O\nwith O\nother O\nnations O\n. O\n\n\" O\nI O\ndo O\nnot O\nvisualise O\nits O\nstraining O\nour O\nbilateral O\nrelations O\nwith O\nany O\ncountry O\n. O\n\nThe O\ntext O\nhas O\nalready O\nbeen O\nblocked O\n, O\n\" O\nhe O\nsaid O\n. O\n\nGujral B-PER\nsaid O\nIndia B-LOC\nwould O\nre-examine O\nits O\nposition O\nif O\nthe O\ntreaty O\n, O\nparticularly O\na O\nclause O\nproviding O\nfor O\nits O\nentry O\ninto O\nforce O\n, O\nwas O\nmodified O\n. O\n\nAsked O\nwhat O\nIndia B-LOC\nwould O\ndo O\nif O\nthe O\npact O\nwere O\nforwarded O\nto O\nthe O\nUnited B-ORG\nNations I-ORG\nGeneral I-ORG\nAssembly I-ORG\n, O\nGujral B-PER\nsaid O\n: O\n\" O\nThat O\nbridge O\nI O\nwill O\ncross O\nwhen O\nI O\ncome O\nto O\nit O\n. O\n\" O\n\nIn O\na O\nwritten O\nstatement O\nreleased O\nat O\nthe O\nnews O\nconference O\n, O\nGujral B-PER\nreiterated O\nIndia B-LOC\n's O\nobjections O\nto O\nthe O\ntreaty O\n, O\nunder O\nnegotiation O\nat O\nthe O\nConference B-MISC\non I-MISC\nDisarmament I-MISC\nin O\nGeneva B-LOC\n. O\n\n\" O\nIt O\nis O\na O\nsad O\nfact O\nthat O\nthe O\nnuclear O\nweapon O\nstates O\nshow O\nno O\ninterest O\nin O\ngiving O\nup O\ntheir O\nnuclear O\nhegemony O\n, O\n\" O\nthe O\nstatement O\nsaid O\n. O\n\nGujral B-PER\nsaid O\nIndia B-LOC\nhad O\nnational O\nsecurity O\nconcerns O\nthat O\nmade O\nit O\nimpossible O\nfor O\nNew B-LOC\nDelhi I-LOC\nto O\nsign O\nthe O\nCTBT B-MISC\n. O\n\n\" O\nOur O\nsecurity O\nconcerns O\noblige O\nus O\nto O\nmaintain O\nour O\nnuclear O\noption O\n, O\n\" O\nhe O\nsaid O\n, O\nadding O\nthat O\nIndia B-LOC\nhad O\nexercised O\nrestraint O\nin O\nnot O\ncarrying O\nout O\nany O\nnuclear O\ntests O\nsince O\nthe O\ncountry O\n's O\nlone O\ntest O\nblast O\nin O\n1974 O\n. O\n\nHe O\nsaid O\n: O\n\" O\nWe O\ncannot O\naccept O\nconstraints O\non O\nour O\noption O\nas O\nlong O\nas O\nnuclear O\nweapon O\nstates O\ncontinue O\nto O\nrely O\non O\ntheir O\nnuclear O\narsenals O\nfor O\ntheir O\nsecurity O\n\" O\n. O\n\n-DOCSTART- O\n\nBritain B-LOC\nsays O\ndeath O\nof O\nits O\ncitizen O\nwill O\nsour O\nties O\n. O\n\nDHAKA B-LOC\n1996-08-22 O\n\nA O\nBritish B-MISC\nminister O\nexpressed O\nhis O\ngovernment O\n's O\nofficial O\ndisquiet O\non O\nThursday O\nat O\nthe O\nrecent O\ndeath O\nof O\na O\nBritish B-MISC\ncitizen O\nof O\nBangladeshi B-MISC\norigin O\nat O\nDhaka B-LOC\nairport O\n. O\n\n\" O\nI O\nhave O\ntold O\nBangladesh B-LOC\nleaders O\nthat O\nBritish B-MISC\ngoverment O\nhas O\nattached O\nserious O\nimportance O\nto O\nthe O\nresolution O\nof O\nthe O\ntragic O\ndeath O\nof O\nSiraj B-PER\nMia I-PER\n, O\n\" O\nUnder-Secretary O\nof O\nState O\nfor O\nForeign O\nand O\nCommonwealth B-ORG\nAffairs O\nLiam B-PER\nFox I-PER\nFox I-PER\n, O\ntold O\nreporters O\n. O\n\nSiraj B-PER\nMia I-PER\ndied O\nat O\nDhaka B-LOC\nairport O\non O\nMay O\n9 O\nduring O\ninterogation O\nby O\ncustoms O\nofficials O\nafter O\narriving O\nfrom O\nLondon B-LOC\n. O\n\nHis O\nbody O\nbore O\nmultiple O\ninjuries O\n, O\nand O\nhis O\nrelatives O\ncomplained O\nthat O\nhe O\nwas O\nmurdered O\n. O\n\nA O\npost-mortem O\nreport O\nsuggested O\nhe O\nmight O\nhave O\nbeen O\ntortured O\n. O\n\nBut O\ncustoms O\nauthorities O\nsaid O\nthe O\npassenger O\nwas O\ndrunk O\nand O\ndied O\nof O\nloss O\nof O\nblood O\nfrom O\na O\ndeep O\ncut O\nin O\nhis O\nwrist O\nafter O\nhe O\nhit O\na O\nglass O\nsheet O\n. O\n\nFox B-PER\n, O\nwho O\narrived O\nin O\nBangladesh B-LOC\non O\nTuesday O\non O\nfour-day O\nvisit O\n, O\nsaid O\nBritain B-LOC\nwanted O\nDhaka B-LOC\nto O\nact O\nseriously O\non O\nthe O\ncase O\n. O\n\n\" O\nThis O\nis O\none O\nof O\nthe O\nreasons O\nof O\nmy O\nvisit O\nhere O\n... O\n\nthis O\nis O\nan O\nimportant O\nissue O\nin O\nour O\nrelationship O\n\" O\n, O\nsaid O\nFox B-PER\n, O\nwho O\nis O\ndue O\nto O\nleave O\nfor O\nNepal B-LOC\non O\nFriday O\n. O\n\nFox B-PER\nsaid O\nthe O\nincident O\nhad O\nstrained O\nrelations O\nbetween O\nthe O\ntwo O\ngovernments O\n. O\n\nHe O\nsaid O\nthe O\nMia B-PER\n's O\nissue O\nhad O\nbeen O\nraised O\nin O\nthe O\nHouse B-ORG\nof I-ORG\nCommons I-ORG\n. O\n\nFox B-PER\nsaid O\nhe O\nhad O\nbrought O\nup O\nthe O\nissue O\nat O\nevery O\nmeeting O\nhe O\nhad O\nhad O\nwith O\ngovernment O\nleaders O\nin O\nDhaka B-LOC\n. O\n\nHe O\nsaid O\nthe O\nBangladesh B-LOC\ngovernment O\nhad O\nassured O\nhim O\nit O\nwas O\ntaking O\nthe O\nmatter O\nseriously O\n. O\n\n\" O\nThe O\nBritish B-MISC\ngovernment O\nwants O\na O\nthorough O\ninvestigation O\nand O\na O\njust O\noutcome O\n, O\n\" O\nhe O\nsaid O\n. O\n\nFox B-PER\nsaid O\nthe O\nBritish B-MISC\ngovernment O\nwanted O\nan O\nend O\nto O\nthe O\nalleged O\nharassment O\nof O\nits O\nnationals O\nat O\nDhaka B-LOC\nairport O\nby O\ncustoms O\nofficials O\n. O\n\nBangladesh B-LOC\n's O\nCriminal B-ORG\nInvestigation I-ORG\nDepartment I-ORG\nhas O\ncharged O\ntwo O\nimmigration O\nofficials O\nin O\nconnection O\nwith O\nMia B-PER\n's O\nkilling O\n. O\n\nMia B-PER\n, O\na O\nfather O\nof O\nfive O\nchildren O\n, O\nhad O\na O\nrestaurant O\nbusiness O\nin O\na O\nLondon B-LOC\nsuburb O\n. O\n\n-DOCSTART- O\n\nIndia B-LOC\nfears O\nattempts O\nto O\ndisrupt O\nKashmir B-LOC\npolls O\n. O\n\nSRINAGAR B-LOC\n, O\nIndia B-LOC\n1996-08-22 O\n\nIndia B-LOC\n's O\nHome O\n( O\ninterior O\n) O\nMinister O\naccused O\nPakistan B-LOC\non O\non O\nThursday O\nof O\nplanning O\nto O\ndisrupt O\nstate O\nelections O\nin O\ntroubled O\nJammu B-LOC\nand O\nKashmir B-LOC\nstate O\n. O\n\n\" O\nIt O\nseems O\nthat O\nfrom O\nacross O\nthe O\nborder O\nthere O\nis O\ngoing O\nto O\nbe O\na O\nplanned O\nattempt O\nto O\ndisrupt O\nthe O\nelections O\n, O\n\" O\nInderjit B-PER\nGupta I-PER\ntold O\nreporters O\nin O\nthe O\nstate O\ncapital O\nSrinagar B-LOC\n. O\n\nThe O\nlocal O\npolls O\nnext O\nmonth O\nwill O\nbe O\nthe O\nfirst O\nsince O\n1987 O\nin O\nthe O\nstate O\n, O\nclamped O\nunder O\ndirect O\nrule O\nfrom O\nNew B-LOC\nDelhi I-LOC\nsince O\n1990 O\n. O\n\nIndia B-LOC\nhas O\noften O\naccused O\nPakistan B-LOC\nof O\nabetting O\nmilitancy O\nin O\nthe O\nvalley O\n, O\na O\ncharge O\nIslamabad B-LOC\nhas O\nalways O\ndenied O\n. O\n\nGupta B-PER\nsaid O\nthere O\nmight O\nbe O\nan O\nincrease O\nin O\nthe O\nnumber O\nof O\npeople O\ninfiltrating O\nthe O\nKashmir B-LOC\nvalley O\nto O\ncreate O\ndisturbance O\nin O\nthe O\nregion O\n. O\n\n\" O\nWe O\nnoticed O\namong O\nthe O\npeople O\nwho O\ncome O\nfrom O\nacross O\nthe O\nborder O\n, O\nthere O\nis O\na O\ngrowing O\nnumber O\nof O\nforeign O\nmercenaries O\n, O\n\" O\nGupta B-PER\nsaid O\n. O\n\nIndia B-LOC\nand O\nPakistan B-LOC\nhave O\nfought O\ntwo O\nof O\ntheir O\nthree O\nwars O\nover O\nthe O\ntroubled O\nregion O\nof O\nKashmir B-LOC\nsince O\nindependence O\nfrom O\nBritain B-LOC\nin O\n1947 O\n. O\n\nPrime O\nMinister O\nH.D. B-PER\nDeve I-PER\nGowda I-PER\n's O\ncentre-left O\ngovernment O\nhopes O\nthe O\nelections O\nwill O\nhelp O\nrestore O\nnormality O\nand O\ndemocratic O\nrule O\nin O\nJammu B-LOC\nand O\nKashmir B-LOC\n, O\nwhere O\nmore O\nthan O\n20,000 O\npeople O\nhave O\ndied O\nin O\ninsurgency-related O\nviolence O\nsince O\n1990 O\n. O\n\nOver O\na O\ndozen O\nmilitant O\ngroups O\nare O\nfighting O\nNew B-LOC\nDelhi I-LOC\n's O\nrule O\nin O\nthe O\nstate O\n. O\n\n-DOCSTART- O\n\nDhaka B-LOC\nstocks O\nend O\nup O\non O\ngains O\nby O\nengineering O\n, O\nbanks O\n. O\n\nDHAKA B-LOC\n1996-08-22 O\n\nDhaka B-LOC\nstocks O\nedged O\nup O\non O\nsharply O\nhigher O\nvolume O\nas O\nengineering O\nand O\ncash O\nshares O\ngained O\namid O\nbuying O\nby O\nboth O\nsmall O\nand O\ninstitutional O\ninvestors O\n, O\nbrokers O\nsaid O\n. O\n\nThe O\nDhaka B-ORG\nStock I-ORG\nExchange I-ORG\n( O\nDSE B-ORG\n) O\nall-share O\nprice O\nindex O\nrose O\n8.05 O\npoints O\nor O\n0.7 O\npercent O\nto O\n1,156.79 O\non O\na O\nturnover O\nof O\n146.2 O\nmillion O\ntaka O\n. O\n\nOf O\nthe O\ntotal O\n119 O\nissues O\ntraded O\n71 O\nclosed O\nhigher O\n, O\n44 O\nended O\nlower O\nand O\nfour O\nremained O\nunchanged O\n. O\n\n. O\n\nNational B-ORG\nBank I-ORG\nrose O\n12.71 O\ntaka O\nto O\n228.7 O\n, O\nEastern B-ORG\nCables I-ORG\ngained O\n20.37 O\nto O\n677.98 O\nand O\nApex B-ORG\nTannery I-ORG\nlost O\n22.72 O\nto O\n597 O\n. O\n\nBrokers O\nsaid O\nthe O\nstocks O\nrecovered O\nearly O\nlosses O\nto O\nedge O\nup O\nat O\nclose O\nbecause O\nof O\ninstitutional O\nsupport O\nand O\nshort-covering O\nahead O\nof O\nFriday O\nweekend O\n. O\n\n-DOCSTART- O\n\nIndia B-LOC\nRBI B-ORG\nchief O\nsees O\ncut O\nin O\ncash O\nreserve O\nratio O\n. O\n\nNEW B-LOC\nDELHI I-LOC\n1996-08-22 O\n\nThe O\nReserve B-ORG\nbank I-ORG\nof I-ORG\nIndia I-ORG\ngovernor O\nC. B-PER\nRangarajan I-PER\nsaid O\non O\nThursday O\nthat O\nhe O\nexpected O\nthe O\ncash O\nreserve O\nratio O\n( O\nCRR O\n) O\nmaintained O\nby O\nbanks O\nto O\nbe O\nreduced O\nover O\nthe O\nmedium O\nterm O\n. O\n\n\" O\nOver O\nthe O\nmedium O\nterm O\n, O\nyes O\n, O\n\" O\nhe O\ntold O\nReuters B-ORG\nafter O\naddressing O\nindustrialists O\nin O\nthe O\ncapital O\n. O\n\nHe O\ndenied O\nhaving O\nsaid O\nin O\na O\nrecent O\nnewspaper O\ninterview O\nthat O\nthe O\nCRR O\ncould O\nbe O\nraised O\nif O\nnecessary O\n. O\n\nHe O\nsaid O\nhe O\nwas O\nonly O\ntrying O\n( O\nin O\nthat O\nnewspaper O\nreport O\n) O\nto O\nexplain O\nthe O\ntheoretical O\nposition O\non O\nthe O\nuse O\nof O\nthe O\nCRR O\nby O\ncentral O\nbanks O\nto O\nmanage O\nmoney O\nsupply O\n. O\n\nRangarajan B-PER\nexplained O\nthat O\nthe O\ncash O\nreserve O\nratio O\nwas O\nan O\ninstrument O\nthat O\ncentral O\nbanks O\ncould O\nuse O\nto O\nregulate O\nmoney O\nsupply O\nby O\nreducing O\nor O\nincreasing O\nthe O\nratio O\n. O\n\nBut O\nin O\nthe O\ncurrent O\ncontext O\n, O\nthe O\ngovernment O\nstood O\nby O\nan O\nearlier O\ncommitment O\nto O\nreduce O\nit O\nover O\na O\nperiod O\nof O\ntime O\n, O\nhe O\nsaid O\nin O\nresponse O\nto O\na O\nquestion O\n. O\n\n-- O\nNew B-LOC\nDelhi I-LOC\nnewsroom O\n, O\n+91-11-3012024 O\n\n-DOCSTART- O\n\nTwo O\npct O\nIndia B-LOC\ncurrent O\naccount O\ndeficit O\nviable O\n- O\nRBI B-ORG\n. O\n\nBOMBAY B-LOC\n1996-08-22 O\n\nThe O\nReserve B-ORG\nBank I-ORG\nof I-ORG\nIndia I-ORG\nGovernor O\nChakravarty B-PER\nRangarajan I-PER\nsaid O\non O\nThursday O\nthat O\na O\ncurrent O\naccount O\ndeficit O\nof O\ntwo O\npercent O\nof O\ngross O\ndomestic O\nproduct O\n( O\nGDP O\n) O\nwas O\nsustainable O\ngiven O\nthe O\ncurrrent O\nrate O\nof O\ngrowth O\n. O\n\n\" O\nThe O\ncurrent O\naccount O\ndeficit O\nof O\naround O\ntwo O\npercent O\nof O\nGDP O\nis O\na O\nsustainable O\nlevel O\nof O\ndeficit O\ngiven O\nthe O\nexpected O\nreal O\ngrowth O\nrate O\nand O\nthe O\ntrends O\nin O\nimports O\nand O\nexports O\n, O\n\" O\nRangarajan B-PER\nsaid O\nin O\nan O\naddress O\nto O\nbusiness O\nleaders O\nin O\nNew B-LOC\nDelhi I-LOC\n. O\n\nRangarajan B-PER\nsaid O\na O\ncurrent O\naccount O\ndeficit O\nof O\ntwo O\npercent O\nbrought O\nabout O\nby O\na O\n16-17 O\npercent O\nannual O\ngrowth O\nin O\nexports O\nand O\na O\n14-15 O\npercent O\nrise O\nin O\nimports O\nalong O\nwith O\nan O\nincrease O\nin O\nnon-debt O\nflows O\ncould O\nlead O\nto O\na O\nreduction O\nin O\nthe O\ndebt-service O\nratio O\nto O\nbelow O\n20 O\npercent O\nover O\nthe O\nnext O\nfive O\nyears O\n. O\n\n-- O\nBombay B-LOC\nnewsroom O\n+91-22-265 O\n9000 O\n\n-DOCSTART- O\n\nMother B-PER\nTeresa I-PER\ndevoted O\nto O\nworld O\n's O\npoor O\n. O\n\nCALCUTTA B-LOC\n1996-08-22 O\n\nMother B-PER\nTeresa I-PER\n, O\nknown O\nas O\nthe O\nSaint B-PER\nof I-PER\nthe I-PER\nGutters I-PER\n, O\nwon O\nthe O\nNobel B-MISC\nPeace I-MISC\nPrize I-MISC\nin O\n1979 O\nfor O\nbringing O\nhope O\nand O\ndignity O\nto O\nmillions O\nof O\npoor O\n, O\nunwanted O\npeople O\nwith O\nher O\nsimple O\nmessage O\n: O\n\" O\nThe O\npoor O\nmust O\nknow O\nthat O\nwe O\nlove O\nthem O\n. O\n\" O\n\nWhile O\nthe O\nworld O\nheaps O\nhonours O\non O\nher O\nand O\neven O\nregards O\nher O\nas O\na O\nliving O\nsaint O\n, O\nthe O\nnun O\nof O\nAlbanian B-MISC\ndescent O\nmaintains O\nshe O\nis O\nmerely O\ndoing O\nGod B-PER\n's O\nwork O\n. O\n\n\" O\nIt O\ngives O\nme O\ngreat O\njoy O\nand O\nfulfilment O\nto O\nlove O\nand O\ncare O\nfor O\nthe O\npoor O\nand O\nneglected O\n, O\n\" O\nshe O\nsaid O\n. O\n\" O\n\nThe O\npoor O\ndo O\nnot O\nneed O\nour O\nsympathy O\nand O\npity O\n. O\n\nThey O\nneed O\nour O\nlove O\nand O\ncompassion O\n. O\n\" O\n\nThe O\ndiminutive O\nRoman B-MISC\nCatholic I-MISC\nmissionary O\nwas O\non O\nrespiratory O\nsupport O\nin O\nintensive O\ncare O\nin O\nan O\nIndian B-MISC\nnursing O\nhome O\non O\nThursday O\nafter O\nsuffering O\nheart O\nfailure O\n. O\n\nBut O\nan O\nattending O\ndoctor O\nsaid O\nMother B-PER\nTeresa I-PER\n, O\nwho O\nturns O\n86 O\nnext O\nTuesday O\n, O\nwas O\nconscious O\nand O\nin O\nstable O\ncondition O\n. O\n\nThe O\ntask O\nMother B-PER\nTeresa I-PER\nbegan O\nalone O\nin O\n1949 O\nin O\nthe O\nslums O\nof O\ndensely-populated O\nCalcutta B-LOC\n, O\nand O\ngrew O\nto O\ntouch O\nthe O\nhearts O\nof O\npeople O\naround O\nthe O\nworld O\n. O\n\nWhen O\nin O\n1979 O\nshe O\nwas O\ntold O\nshe O\nhad O\nwon O\nthe O\nNobel B-MISC\nPeace I-MISC\nPrize I-MISC\n, O\nshe O\nsaid O\ncharacteristically O\n: O\n\" O\nI O\nam O\nunworthy O\n. O\n\" O\n\nThe O\nworld O\ndisagreed O\n, O\nshowering O\nmore O\nthan O\n80 O\nnational O\nand O\ninternational O\nhonours O\non O\nher O\nincluding O\nthe O\nBharat B-MISC\nRatna I-MISC\n, O\nor O\nJewel B-MISC\nof I-MISC\nIndia I-MISC\n, O\nthe O\ncountry O\n's O\nhighest O\ncivilian O\naward O\n. O\n\nHer O\nhealth O\nbegan O\nto O\ndeteriorate O\nin O\n1989 O\nwhen O\nshe O\nwas O\nfitted O\nwith O\na O\nheart O\npacemaker O\n. O\n\nA O\nyear O\nlater O\n, O\nthe O\nVatican B-LOC\nannounced O\nshe O\nwas O\nstepping O\ndown O\nas O\nSuperior O\nof O\nher O\nMissionaries B-ORG\nof I-ORG\nCharity I-ORG\norder O\n. O\n\nMore O\nthan O\n100 O\ndelegates O\nflew O\nin O\nfrom O\naround O\nthe O\nworld O\nto O\nelect O\na O\nsuccessor O\n. O\n\nThey O\ncould O\nnot O\nagree O\n, O\nso O\nasked O\nher O\nto O\nstay O\non O\n. O\n\nShe O\nagreed O\n. O\n\nIn O\n1991 O\n, O\nMother B-PER\nTeresa I-PER\nwas O\ntreated O\nat O\na O\nCalifornia B-LOC\nhospital O\nfor O\nheart O\ndisease O\nand O\nbacterial O\npneumonia O\n. O\n\nIn O\n1993 O\n, O\nshe O\nfell O\nin O\nRome B-LOC\nand O\nbroke O\nthree O\nribs O\n. O\n\nIn O\nAugust O\nthe O\nsame O\nyear O\n, O\nwhile O\nin O\nNew B-LOC\nDelhi I-LOC\nto O\nreceive O\nyet O\nanother O\naward O\n, O\nshe O\ndeveloped O\nmalaria O\n, O\ncomplicated O\nby O\nher O\nheart O\nand O\nlung O\nproblems O\n. O\n\nLast O\nApril O\nshe O\nfractured O\nher O\nleft O\ncollar O\nbone O\n. O\n\nBut O\nher O\nincreasing O\nfrailty O\n, O\narthritis O\nand O\nfailing O\neyesight O\nhas O\nnot O\nstopped O\nher O\ntravels O\naround O\nthe O\nworld O\nto O\nmingle O\nwith O\nthe O\npoor O\nand O\ndesperate O\n. O\n\nMother B-PER\nTeresa I-PER\nwas O\nborn O\nAgnes B-PER\nGoinxha I-PER\nBejaxhiu I-PER\nto O\nAlbanian B-MISC\nparents O\nin O\nSkopje B-LOC\n, O\nin O\nwhat O\nwas O\nthen O\nSerbia B-LOC\n, O\non O\nAugust O\n27 O\n, O\n1910 O\n. O\n\nShe O\nattended O\na O\ngovernment O\nschool O\nand O\nwas O\nalready O\ndeeply O\nreligious O\nby O\nthe O\ntime O\nshe O\nwas O\n12 O\n. O\n\nAt O\nthe O\nage O\nof O\n18 O\nshe O\nbecame O\na O\nLoretto B-MISC\nnun O\n, O\nhoping O\nto O\nwork O\nat O\nthe O\nOrder O\n's O\nCalcutta B-LOC\nmission O\n. O\n\nShe O\nwas O\nsent O\nto O\nLoretto B-LOC\nAbbey I-LOC\nin O\nDublin B-LOC\nand O\nfrom O\nthere O\nto O\nIndia B-LOC\nto O\nbegin O\nher O\nnovitiate O\nand O\nteach O\ngeography O\nat O\na O\nconvent O\nschool O\nin O\nCalcutta B-LOC\n. O\n\nShe O\nsaid O\nher O\ndivine O\ncall O\nto O\nwork O\namong O\nthe O\npoor O\ncame O\nin O\nSeptember O\n, O\n1946 O\n. O\n\" O\n\nThe O\nmessage O\nwas O\nquite O\nclear O\n, O\n\" O\nshe O\ntold O\none O\ninterviewer O\n. O\n\" O\n\nI O\nwas O\nto O\nleave O\nthe O\nconvent O\nand O\nhelp O\nthe O\npoor O\nwhile O\nliving O\namong O\nthem O\n. O\n\nIt O\nwas O\nan O\norder O\n. O\n\nI O\nknew O\nwhere O\nI O\nbelonged O\n. O\n\" O\n\nThe O\nVatican B-LOC\nand O\nthe O\nmother O\nsuperior O\nin O\nDublin B-LOC\napproved O\nand O\nafter O\nintensive O\ntraining O\nas O\na O\nnurse O\nwith O\nAmerican B-MISC\nmissionaries O\nshe O\nopened O\nher O\nfirst O\nCalcutta B-LOC\nslum O\nschool O\nin O\nDecember O\n1949 O\n. O\n\nShe O\ntook O\nthe O\nname O\nof O\nTeresa B-PER\n, O\nafter O\nFrance B-LOC\n's O\nSaint O\nTherese B-PER\nof O\nthe O\nChild O\nJesus B-PER\n. O\n\nIn O\nIndia B-LOC\nshe O\nwas O\nsimply O\ncalled O\nMother B-PER\n. O\n\nMother B-PER\nTeresa I-PER\nset O\nup O\nher O\nfirst O\nhome O\nfor O\nthe O\ndying O\nin O\na O\nHindu B-MISC\nrest O\nhouse O\nin O\nCalcutta B-LOC\nafter O\nshe O\nsaw O\na O\npenniless O\nwoman O\nturned O\naway O\nby O\na O\ncity O\nhospital O\n. O\n\nNamed O\n\" O\nNirmal B-LOC\nHriday I-LOC\n\" O\n( O\nTender B-LOC\nHeart I-LOC\n) O\n, O\nit O\nwas O\nthe O\nfirst O\nof O\na O\nchain O\nof O\n150 O\nhomes O\nfor O\ndying O\n, O\ndestitute O\npeople O\n, O\nadmitting O\nnearly O\n18,000 O\na O\nyear O\n. O\n\nHer O\nMissionaries B-ORG\nof I-ORG\nCharity I-ORG\n, O\na O\nRoman B-MISC\nCatholic I-MISC\nreligious O\norder O\nshe O\nfounded O\nin O\n1949 O\n, O\nnow O\nruns O\nabout O\n300 O\nhomes O\nfor O\nunwanted O\nchildren O\nand O\nthe O\ndestitute O\nin O\nIndia B-LOC\nand O\nabroad O\n. O\n\nIn O\n1994 O\na O\nBritish B-MISC\ntelevision O\ndocumentary O\ncalled O\nthe O\nmyth O\naround O\nMother B-PER\nTeresa I-PER\na O\nmixture O\nof O\n\" O\nhyperbole O\nand O\ncredulity O\n\" O\n. O\n\nCatholics B-MISC\naround O\nthe O\nworld O\nrose O\nto O\nher O\ndefence O\n. O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nFOCUS-News O\nforecasts O\nalien-led O\nprofit O\nboost O\n. O\n\nBernard B-PER\nHickey I-PER\n\nSYDNEY B-LOC\n1996-08-22 O\n\nMedia O\nbaron O\nRupert B-PER\nMurdoch I-PER\n's O\nNews B-ORG\nCorp I-ORG\nLtd I-ORG\nreported O\nlower O\nthan O\nexpected O\n1995/96 O\nprofits O\non O\nThursday O\n, O\nbut O\nforecast O\nthat O\nthe O\nhit O\nfilm O\n\" O\nIndependence B-MISC\nDay I-MISC\n\" O\nwould O\nhelp O\nincrease O\nprofits O\nby O\nat O\nleast O\n20 O\npercent O\nin O\n1996/97 O\n. O\n\n\" O\nFrom O\nan O\nearnings O\nperspective O\n, O\nthe O\ncurrent O\nfiscal O\nyear O\nhas O\nbegun O\nwith O\ngreat O\npromise O\ndue O\nto O\nthe O\nhit O\nmotion O\npicture O\n' O\nIndependence B-MISC\nDay I-MISC\n, O\n' O\n\" O\nNews B-ORG\nCorp I-ORG\nsaid O\nin O\na O\nstatement O\nannouncing O\nits O\nresults O\nfor O\nthe O\nyear O\nto O\nJune O\n30 O\n, O\n1996 O\n. O\n\nIt O\nsaid O\nmoderating O\npaper O\nprices O\nand O\nsolid O\norders O\nfor O\nadvertising O\nat O\nits O\nFox B-ORG\nBroadcasting I-ORG\ntelevision O\nnetwork O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\nwould O\nalso O\nhelp O\nboost O\nprofits O\nin O\nthe O\n1996/97 O\nyear O\n. O\n\" O\n\nA O\nbudgeted O\nprofit O\nincrease O\nof O\nat O\nleast O\n20 O\npercent O\nfor O\nthe O\nfull O\nyear O\ncurrently O\nappears O\nvery O\nattainable O\n, O\n\" O\nNews B-ORG\nCorp I-ORG\nsaid O\n. O\n\nThe O\nbullish O\ncomments O\nfor O\nthe O\ncoming O\nyear O\nsoothed O\nanalysts O\nand O\nmost O\nshareholders O\n, O\nwho O\nwere O\ndisappointed O\nby O\nthe O\nlower O\nthan O\nexpected O\nprofit O\nfor O\n1995/96 O\n. O\n\nNews B-ORG\nannounced O\npre-abnormals O\nnet O\nprofit O\nfor O\nthe O\nyear O\nfell O\nsix O\npercent O\nto O\nA$ B-MISC\n1.26 O\nbillion O\n( O\nUS$ B-MISC\n995 O\nmillion O\n) O\nand O\nearnings O\nper O\nshare O\ndropped O\nto O\n40 O\ncents O\nfrom O\n46 O\ncents O\n. O\n\nAnalysts O\nhad O\non O\naverage O\nexpected O\na O\npre-abnormals O\nprofit O\nof O\nA$ B-MISC\n1.343 O\nbillion O\n. O\n\n\" O\nThe O\nyear O\njust O\ngone O\nwas O\ndisappointing O\n, O\nbut O\nthe O\noutlook O\nfor O\nthe O\ncurrent O\nyear O\nlooks O\ngood O\n, O\n\" O\nFirst B-ORG\nPacific I-ORG\nmedia O\nanalyst O\nLachlan B-PER\nDrummond I-PER\nsaid O\n. O\n\nNews B-ORG\nCorp I-ORG\nsaid O\nstrong O\nperformances O\nin O\nU.S. B-LOC\ntelevision O\nand O\nBritish B-MISC\nnewspapers O\nwere O\noffset O\nby O\nlower O\nprofits O\nfrom O\nNews B-ORG\nCorp I-ORG\n's O\nmagazine O\nand O\npublishing O\ndivisions O\nand O\nfurther O\nhefty O\nlosses O\nfrom O\nits O\nAsian B-ORG\nStar I-ORG\nTV I-ORG\noperations O\n. O\n\nHigher O\nnewsprint O\nprices O\nhit O\nprofits O\nhard O\n. O\n\" O\n\nThroughout O\nthe O\ngroup O\n, O\nhigher O\npaper O\nprices O\nincreased O\ncosts O\nby O\nover O\nUS$ B-MISC\n300 O\nmillion O\n, O\n\" O\nit O\nsaid O\n. O\n\nNews B-ORG\nCorp I-ORG\nsaid O\nBritish B-MISC\nnewspaper O\noperating O\nprofits O\nrose O\n10 O\npercent O\nfor O\nthe O\nyear O\n, O\nas O\nhigher O\ncover O\nprices O\nat O\nThe B-ORG\nSun I-ORG\nand O\nThe B-ORG\nTimes I-ORG\nand O\nhigher O\nadvertising O\nvolumes O\noffset O\nincreased O\nnewsprint O\ncosts O\n. O\n\nAdvertising O\nrevenues O\nat O\nThe B-ORG\nTimes I-ORG\ngrew O\n20 O\npercent O\n. O\n\nAnalysts O\nsaid O\nsharply O\nlower O\nearnings O\nfrom O\nNews B-ORG\nCorp I-ORG\n's O\nbook O\npublishing O\ndivision O\nand O\nits O\nU.S. B-LOC\nmagazines O\nhad O\nbeen O\nthe O\nmajor O\nsurprises O\nin O\nthe O\nresults O\nfor O\n1995/96 O\n. O\n\nNews B-ORG\nCorp I-ORG\nsaid O\nrevenue O\ngains O\nat O\nits O\nmagazines O\nand O\ninserts O\ndivision O\nwere O\noffset O\nby O\nhigher O\npaper O\nprices O\nand O\nlower O\nsales O\nat O\nthe O\nU.S. B-LOC\nTV B-ORG\nGuide I-ORG\n. O\n\nNews B-ORG\nsaid O\ndramatically O\nlower O\nearnings O\nfrom O\nthe O\nBritish B-MISC\narm O\nof O\nits O\nHarper-Collins B-ORG\npublishing O\ndivision O\nmore O\nthan O\noffset O\nhealthy O\nresults O\nfrom O\nits O\nU.S. B-LOC\noperation O\n. O\n\nIt O\nsaid O\nthe O\ndemise O\nof O\nthe O\nNet B-MISC\nBook I-MISC\nAgreement I-MISC\nhad O\nhurt O\nthe O\nBritish B-MISC\noperations O\n, O\nand O\nweak O\nperformances O\nfrom O\nthe O\nSan B-LOC\nFrancisco I-LOC\nunit O\nof O\nHarper-Collins B-ORG\nhad O\nnot O\nhelped O\n. O\n\nThe O\nminimum O\nprice O\nsetting O\nexpired O\nlast O\nSeptember O\nwhen O\nthree O\npublishers O\npulled O\nout O\n. O\n\nBut O\nit O\nwas O\nthe O\nbullish O\nprofit O\nforecast O\nfor O\n1996/97 O\nthat O\ntook O\nthe O\nspotlight O\nin O\nthe O\nmarket O\n, O\nwith O\nsome O\nanalysts O\nsaying O\n20 O\npercent O\nmay O\neven O\nbe O\nan O\nunderstatement O\n. O\n\n\" O\nIf O\nthey O\n're O\nsaying O\nat O\nleast O\n20 O\npercent O\n, O\nthen O\ntheir O\ninternal O\nforecasts O\nare O\nprobably O\nsaying O\n25 O\nor O\n30 O\npercent O\n, O\n\" O\nsaid O\none O\nSydney B-LOC\nmedia O\nanalyst O\nwho O\ndeclined O\nto O\nbe O\nnamed O\n. O\n\nNews B-ORG\nCorp I-ORG\n's O\nshares O\nwere O\ndown O\neight O\ncents O\nat O\nA$ B-MISC\n6.39 O\nat O\n2.00 O\np.m. O\n( O\n0400 O\nGMT B-MISC\n) O\nin O\na O\nsoft O\nmarket O\n. O\n\n( O\nA$ B-MISC\n1 O\n= O\nUS$ B-MISC\n0.79 O\n) O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n373-1800 O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nBudget O\ncuts O\nto O\nboost O\nAustralia B-LOC\nsavings O\n- O\nRBA B-ORG\n. O\n\nCANBERRA B-LOC\n1996-08-22 O\n\nThe O\nAustralian B-MISC\ngovernment O\n's O\nplans O\nto O\nslash O\nits O\nbudget O\ndeficit O\nshould O\nmake O\na O\nuseful O\ncontribution O\nto O\nnational O\nsavings O\n, O\nthe O\nReserve B-ORG\nBank I-ORG\nof I-ORG\nAustralia I-ORG\n( O\nRBA B-ORG\n) O\nsaid O\nin O\nits O\nannual O\nreport O\n. O\n\n\" O\nThe O\ngovernment O\n's O\nannounced O\nplans O\nto O\nbalance O\nthe O\nbudget O\n, O\nif O\nrealised O\n, O\nwould O\nmake O\na O\nuseful O\ncontribution O\nto O\nraising O\nnational O\nsavings O\n, O\n\" O\nthe O\nRBA B-ORG\nsaid O\n. O\n\nThe O\nbank O\nsaid O\nthere O\nwere O\nconcerns O\nfiscal O\nconsolidation O\nwould O\nunduly O\nrestrict O\ngrowth O\n, O\nbut O\nevidence O\nwas O\nambiguous O\n. O\n\nIn O\nits O\n1996/97 O\nbudget O\nannounced O\non O\nTuesday O\n, O\nthe O\nAustralian B-MISC\nCoalition B-ORG\ngovernment O\nannounced O\nan O\nunderlying O\nbudget O\ndeficit O\nof O\nA$ B-MISC\n5.65 O\nbillion O\n, O\nand O\npledged O\nto O\nreturn O\nthe O\nunderlying O\nbudget O\nbalance O\nto O\nsurplus O\nby O\n1998/99 O\n. O\n\nThe O\nbudget O\ndeficit O\nwas O\nA$ B-MISC\n10.3 O\nbillion O\nin O\n1995/96 O\n. O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373-1800 O\n\n\" O\nDetermined O\nand O\ncredible O\nefforts O\nto O\nrein O\nin O\nunsustainable O\nfiscal O\npositions O\n( O\nare O\n) O\noften O\nrewarded O\nby O\nrising O\nconfidence O\n, O\ngiving O\nfavourable O\neffects O\non O\neconomic O\nactivity O\neven O\nin O\nthe O\nshort O\nterm O\n, O\n\" O\nit O\nsaid O\n. O\n\n\" O\nMore O\ngenerally O\n, O\nthe O\nlong-term O\neffects O\nof O\nfiscal O\nconsolidation O\nare O\nclearly O\npositive O\n, O\nwith O\nhigher O\nsaving O\ntending O\nto O\npromote O\neconomic O\ngrowth O\nby O\nraising O\ninvestment O\nand O\nlowering O\nlong-term O\nreal O\ninterest O\nrates O\n, O\n\" O\nthe O\nRBA B-ORG\nsaid O\n. O\n\n-DOCSTART- O\n\nBNZ B-ORG\ncuts O\nNZ B-LOC\nfixed O\nhome O\nlending O\nrates O\n. O\n\nWELLINGTON B-LOC\n1996-08-22 O\n\nBank B-ORG\nof I-ORG\nNew I-ORG\nZealand I-ORG\nsaid O\non O\nThursday O\nit O\nwas O\ncutting O\nits O\nfixed O\nhome O\nlending O\nrates O\n. O\n\nThe O\nrates O\nare O\n: O\n\nNew O\nrate O\nold O\nrate O\n\nSix O\nmonth O\nrate O\n10.5 O\npct O\n10.75 O\n\nOne O\nyear O\n10.5 O\npct O\n10.95 O\n\nTwo O\nyear O\n10.5 O\npct O\n11.25 O\n\nThree O\nyear O\n10.5 O\npct O\n11.25 O\n\nBNZ B-ORG\nsaid O\nit O\nwas O\nresponding O\nto O\nlower O\nwholesale O\nrates O\n. O\n\nFixed O\nbusiness O\nand O\nfarm O\nlending O\nrates O\nrates O\nwere O\nleft O\nunchanged O\nalthough O\nthey O\nwere O\nunder O\nreview O\n. O\n\n-- O\nWellington B-LOC\nnewsroom O\n64 O\n4 O\n4734 O\n746 O\n\n-DOCSTART- O\n\nPower B-ORG\nNZ I-ORG\nODV I-ORG\nup O\n8 O\npct O\nat O\nNZ$ B-MISC\n524 O\nmillion O\n. O\n\nWELLINGTON B-LOC\n1996-08-22 O\n\nPower B-ORG\nNew I-ORG\nZealand I-ORG\nsaid O\non O\nThursday O\nthat O\nthe O\nOptimised O\nDeprival O\nValue O\n( O\nODV O\n) O\nof O\nits O\nnetwork O\nat O\nMarch O\n31 O\n, O\n1996 O\nhas O\nbeen O\nset O\nat O\n$ O\n524.2 O\nmillion O\n, O\nan O\nincrease O\nof O\neight O\npercent O\non O\nits O\n$ O\n486.5 O\nmillion O\nvaluation O\na O\nyear O\nearlier O\n. O\n\nThe O\ncompany O\nsaid O\nthe O\nincrease O\nreflected O\nthe O\nvalue O\nof O\nextensions O\nto O\nthe O\nnetwork O\nto O\nmeet O\neconomic O\ngrowth O\nin O\nits O\nsupply O\narea O\nand O\nan O\nincrease O\nin O\nthe O\nestimated O\nlifespan O\nof O\nthe O\nnetwork O\n. O\n\nIt O\nsaid O\nthe O\nincrease O\nwas O\nconsistent O\nwith O\nthe O\napproach O\nfollowed O\nby O\nother O\npower O\ncompanies O\nand O\nreflected O\nthe O\ncompany O\n's O\nnew O\nlevels O\nof O\npreventative O\nmaintenance O\nand O\nequipment O\nupgrading O\n. O\n\nThe O\nrevaluation O\nwas O\nundertaken O\nto O\nmeet O\nthe O\ndisclosure O\n\nrequirements O\nof O\nthe O\nMinistry B-ORG\nof I-ORG\nCommerce I-ORG\n. O\n\n-- O\nWellington B-LOC\nnewsroom O\n64 O\n4 O\n4734 O\n746 O\n\n-DOCSTART- O\n\nThais O\nhunt O\nfor O\nAustralian B-MISC\njail O\nbreaker O\n. O\n\nBANGKOK B-LOC\n\nThailand B-LOC\nhas O\nlaunched O\na O\nmanhunt O\nfor O\nan O\nAustralian B-MISC\nwho O\nescaped O\nfrom O\na O\nhigh O\nsecurity O\nprison O\nin O\nBangkok B-LOC\nwhile O\nawaiting O\ntrial O\non O\ndrug O\npossession O\ncharges O\n, O\nofficials O\nsaid O\non O\nThursday O\n. O\n\nDaniel B-PER\nWestlake I-PER\n, O\n46 O\n, O\nfrom O\nVictoria B-LOC\n, O\nmade O\nthe O\nfirst O\nsucessful O\nescape O\nfrom O\nKlongprem B-LOC\nprison O\nin O\nthe O\nnorthern O\noutskirts O\nof O\nthe O\ncapital O\non O\nSunday O\nnight O\n. O\n\nHe O\nwas O\nbelieved O\nby O\nprison O\nofficials O\nto O\nstill O\nbe O\nin O\nThailand B-LOC\n. O\n\n\" O\nWe O\nhave O\nordered O\na O\nmassive O\nhunt O\nfor O\nhim O\nand O\nI O\nam O\nquite O\nconfident O\nwe O\nwill O\nget O\nhim O\nsoon O\n, O\n\" O\nVivit B-PER\nChatuparisut I-PER\n, O\ndeputy O\ndirector O\ngeneral O\nof O\nthe O\nCorrection B-ORG\nDepartment I-ORG\n, O\ntold O\nReuters B-ORG\n. O\n\nWestlake B-PER\n, O\narrested O\nin O\nDecember O\n1993 O\nand O\ncharged O\nwith O\nheroin O\ntrafficking O\n, O\nsawed O\nthe O\niron O\ngrill O\noff O\nhis O\ncell O\nwindow O\nand O\nclimbed O\ndown O\nthe O\nprison O\n's O\nfive-metre O\n( O\n15-foot O\n) O\nwall O\non O\na O\nrope O\nmade O\nfrom O\nbed O\nsheets O\n, O\nVivit O\nsaid O\n. O\n\nThe O\ncorrections O\ndepartment O\nwas O\nprobing O\nthe O\nescape O\nand O\nhad O\nordered O\nall O\nforeign O\ninmates O\nchained O\nto O\nprevent O\nmore O\nbreakouts O\n. O\n\nThere O\nare O\n266 O\nWesterners B-MISC\n, O\nincluding O\nsix O\nAustralians B-MISC\n, O\nin O\nthe O\nprison O\n, O\nmost O\nawaiting O\ntrial O\non O\ndrugs O\ncharges O\n. O\n\nThere O\nalso O\nare O\nabout O\n5,000 O\nThai B-MISC\ninmates O\nin O\nKlongprem B-LOC\n, O\na O\nprison O\nofficial O\nsaid O\n. O\n\n-DOCSTART- O\n\nTokyo B-ORG\nSoir I-ORG\n- O\n1996 O\nparent O\nforecast O\n. O\n\nTOKYO B-LOC\n1996-08-22 O\n\nYear O\nto O\nDecember O\n31 O\n, O\n1996 O\n\n( O\nin O\nbillions O\nof O\nyen O\nunless O\nspecified O\n) O\n\nLATEST O\nACTUAL O\n\n( O\nParent O\n) O\nFORECAST O\nYEAR-AGO O\n\nSales O\n26.00 O\n26.70 O\n\nCurrent O\n400 O\nmillion O\n329 O\nmillion O\n\nNet O\n250 O\nmillion O\n84 O\nmillion O\n\nEPS O\n11.61 O\nyen O\n3.92 O\nyen O\n\nOrd O\ndiv O\n10.00 O\nyen O\n10.00 O\nyen O\n\nNOTE O\n- O\nTokyo B-ORG\nSoir I-ORG\nCo I-ORG\nLtd I-ORG\nis O\na O\nspecialised O\nmanufacturer O\nof O\nwomen O\n\" O\ns O\nformal O\nwear O\n. O\n\n-DOCSTART- O\n\nKa B-ORG\nWah I-ORG\nBank I-ORG\nsets O\nHK$ B-MISC\n43 O\nmln O\nFRCD O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-22 O\n\nKa B-ORG\nWah I-ORG\nBank I-ORG\n's O\nHK$ B-MISC\n43 O\nmillion O\nfloating O\nrate O\ncertificate O\nof O\ndeposit O\nissue O\nhas O\nbeen O\nprivately O\nplaced O\n, O\nsole O\narranger O\nHSBC B-ORG\nMarkets I-ORG\nsaid O\n. O\n\nThe O\nfacility O\nhas O\na O\ntenor O\nof O\nsix O\nmonths O\n. O\n\nIt O\npays O\na O\ncoupon O\nof O\n15 O\nbasis O\npoints O\nover O\nthe O\nsix-month O\nHong B-ORG\nKong I-ORG\nInterbank I-ORG\nOffered O\nRate O\n. O\n\nOther O\ndetails O\nare O\nnot O\navailable O\n. O\n\nThe O\ndeposit O\ndate O\nis O\nSeptember O\n5 O\n, O\n1996 O\n. O\n\nClearing O\nis O\nthrough O\nthe O\nHong B-ORG\nKong I-ORG\nCentral I-ORG\nMoneymarkets I-ORG\nUnit I-ORG\n. O\n\n-- O\nHong B-ORG\nKong I-ORG\nNewsroom I-ORG\n( O\n852 O\n) O\n2847 O\n4039 O\n\n-DOCSTART- O\n\nMalaysia B-LOC\nbans O\nnitrofuran O\nusage O\nin O\nchicken O\nfeed O\n. O\n\nKUALA B-LOC\nLUMPUR I-LOC\n1996-08-22 O\n\nMalaysia B-LOC\nhas O\nbanned O\nthe O\nuse O\nof O\nnitrofuran O\n, O\nan O\nantibiotic O\n, O\nin O\nchicken O\nfeed O\nand O\nveterinary O\napplications O\nbecause O\nit O\nbelieves O\nthe O\ndrug O\ncould O\ncause O\ncancer O\n, O\nthe O\nhealth O\nministry O\nsaid O\non O\nThursday O\n. O\n\n\" O\nIt O\nis O\nhoped O\nthat O\nlivestock O\nbreeders O\nand O\nfeedmillers O\nwill O\nabide O\nby O\nthe O\nlaws O\nand O\nrespect O\nthe O\ncabinet O\ndecision O\nin O\nthe O\ninterest O\nof O\nconsumer O\nsafety O\n, O\n\" O\nHealth O\nMinister O\nChua B-PER\nJui I-PER\nMeng O\nwas O\nquoted O\nas O\nsaying O\nby O\nthe O\nnational O\nBernama B-ORG\nnews O\nagency O\n. O\n\nChua B-PER\nsaid O\noffenders O\ncould O\nface O\na O\ntwo-year O\nprison O\nsentence O\nand O\na O\nmaximum O\nfine O\nof O\n5,000 O\nringgit O\n( O\n$ O\n2000 O\n) O\n. O\n\n\" O\nThe O\nban O\ntakes O\neffect O\nimmediately O\n, O\n\" O\nhe O\nadded O\n. O\n\n-DOCSTART- O\n\nINDONESIAN B-MISC\nSTOCKS O\n- O\nfactors O\nto O\nwatch O\n- O\nAugust O\n22 O\n. O\n\nJAKARTA B-LOC\n1996-08-22 O\n\nFollowing O\nare O\nsome O\nof O\nthe O\nmain O\nfactors O\nlikely O\nto O\naffect O\nIndonesian B-MISC\nstocks O\non O\nThursday O\n: O\n\n** O\nSecurity O\nwas O\ntight O\nin O\nJakarta B-LOC\nahead O\nof O\na O\ntrial O\ninvolving O\nousted O\nIndonesian B-ORG\nDemocratic I-ORG\nParty I-ORG\nleader O\nMegawati B-PER\nSukarnoputri I-PER\n. O\n\nAround O\n200 O\npolice O\nand O\ntroops O\nwere O\nstationed O\noutside O\nthe O\ncourt O\nin O\ncentral O\nJakarta B-LOC\nbut O\nthere O\nwas O\nno O\nsign O\nof O\ndemonstrators O\n. O\n\n** O\nThe O\nDow B-MISC\nJones I-MISC\nindustrial O\naverage O\nclosed O\ndown O\n31.44 O\npoints O\nat O\n5,689.82 O\non O\nWednesday O\n, O\nending O\na O\nthree-session O\nwinning O\nstreak O\nas O\ninvestors O\ntook O\nprofits O\nand O\ntobacco O\nstocks O\ntook O\na O\nbeating O\n. O\n\nMARKETS O\n: O\n\n** O\nThe O\nJakarta B-LOC\ncomposite O\nindex O\nrose O\n2.60 O\npoints O\n, O\nor O\n0.48 O\npercent O\n, O\nto O\n542.20 O\npoints O\non O\nWednesday O\non O\nthe O\nback O\nof O\nbargain-hunting O\nin O\nselected O\nbig-capitalised O\nstocks O\nand O\nsecondliners O\n. O\n\n** O\nOn O\nThursday O\n, O\nthe O\nIndonesian B-MISC\nrupiah O\nwas O\nat O\n2,343.00 O\n/ O\n43.50 O\nin O\nearly O\ntrading O\nagainst O\nan O\nopening O\nof O\n2,342.75 O\n/ O\n43.50 O\n. O\n\nSTOCKS O\nTO O\nWATCH O\n\n** O\nPackaging O\nmanufacturer O\nSuper B-ORG\nIndah I-ORG\nMakmur I-ORG\non O\nannouncement O\nof O\na O\ntender O\noffer O\nby O\nPT B-ORG\nVDH I-ORG\nTeguh I-ORG\nSakti I-ORG\n, O\na O\nwholly-owned O\nsubsidiary O\nof O\nSingapore-listed B-MISC\nVan B-ORG\nDer I-ORG\nHorst I-ORG\n. O\n\n** O\nPrivately-owned O\nBank B-ORG\nDuta I-ORG\non O\nmarket O\ntalk O\nthat O\nit O\nis O\nobtaining O\nfresh O\nsyndicated O\nloans O\n, O\na O\nmanagement O\nreshuffle O\nand O\nfresh O\nequity O\ninjection O\n. O\n\n** O\nCiputra B-ORG\nDevelopment I-ORG\non O\nreports O\nof O\na O\nplan O\nto O\nbuild O\nproperty O\nprojects O\nworth O\n$ O\n2 O\nbillion O\nin O\nJakarta B-LOC\nand O\nSurabaya B-LOC\n. O\n\n-DOCSTART- O\n\nKey O\nstock O\nand O\ncurrency O\nmarket O\nmovements O\nat O\n1600 O\nGMT B-MISC\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nThe O\nfollowing O\ntable O\nshows O\nthe O\nlatest O\nclose O\nof O\nkey O\nindices* O\non O\nmajor O\nworld O\nstock O\nexchanges O\n, O\nthe O\nday O\n's O\nchange O\nin O\npoints O\nand O\nthe O\nindices O\n' O\n1996 O\nclosing O\nhighs O\nand O\nlows O\n( O\nwith O\ndates O\n) O\n. O\n\nAlso O\nshown O\nare O\nthe O\nLondon B-LOC\nclosing O\nvalues O\nof O\nthe O\nGerman B-MISC\nmark O\n, O\nthe O\nJapanese B-MISC\nyen O\n, O\nthe O\nBritish B-MISC\npound O\nand O\ngold O\nbullion O\n( O\nprevious O\nday O\n's O\ncloses O\nin O\nbrackets O\n) O\n: O\n\nAUG O\n23 O\nDAY O\n'S O\nCHANGE O\n1996 O\nHIGH O\n1996 O\nLOW O\n\nCLOSE O\nIN O\nPOINTS O\n\nNEW B-LOC\nYORK I-LOC\n5,710.53 O\n- O\n22.94 O\n5,778.00 O\n5,032.94 O\n\n( O\nmidday O\n) O\n( O\nMay O\n22 O\n) O\n( O\nJan O\n10 O\n) O\n\nLONDON B-LOC\n3,907.5 O\n+16.4 O\n3,907.5 O\n3,632.3 O\n\n( O\nAug O\n23 O\n) O\n( O\nJul O\n16 O\n) O\n\nTOKYO B-LOC\n21,228.80 O\n- O\n134.44 O\n22,666.80 O\n19,734.70 O\n\n( O\nJun O\n26 O\n) O\n( O\nMar O\n13 O\n) O\n\nFRANKFURT B-LOC\n2,555.16 O\n- O\n2.10 O\n2,583.49 O\n) O\n2,284.86 O\n\n( O\nJul O\n5 O\n) O\n( O\nJan O\n2 O\n) O\n\nPARIS B-LOC\n2,020.82 O\n+3.06 O\n2,146.79 O\n1,897.85 O\n\n( O\nApr O\n30 O\n) O\n( O\nJan O\n11 O\n) O\n\nSYDNEY B-LOC\n2,292.9 O\n+18.3 O\n2,326.00 O\n2,096.10 O\n\n( O\nApr O\n26 O\n) O\n( O\nJul O\n17 O\n) O\n\nHONG B-LOC\nKONG I-LOC\n11,424.64 O\n- O\n54.13 O\n11,594.99 O\n10,204.87 O\n\n( O\nFeb O\n16 O\n) O\n( O\nJan O\n2 O\n) O\n\n- O\n- O\n- O\n- O\n\nFOREIGN O\nEXCHANGE O\n/ O\nGOLD O\nBULLION O\nCLOSE O\nIN O\nLONDON B-LOC\n\nDollar O\n/ O\nmark O\n... O\n\n1.4871 O\n( O\n1.4935 O\n) O\n\nDollar O\n/ O\nyen O\n.... O\n\n108.50 O\n( O\n108.43 O\n) O\n\nPound O\n/ O\ndollar O\n.. O\n\n$ O\n1.5520 O\n( O\n$ O\n1.5497 O\n) O\n\nGold O\n( O\nounce O\n) O\n.. O\n\n$ O\n387.50 O\n( O\n$ O\n386.95 O\n) O\n\n- O\n- O\n- O\n- O\n\n*INDICES O\nUSED O\nAND O\nTHEIR O\nALL-TIME O\nCLOSING O\nHIGHS O\n\nNew B-LOC\nYork I-LOC\nDow B-MISC\nJones I-MISC\nindustrial O\naverage O\n-- O\n5,778.00 O\n( O\nMay O\n22/96 O\n) O\n\nLondon B-LOC\nFTSE-100 B-MISC\nindex O\n-- O\n3,907.5 O\n( O\nAug O\n23/96 O\n) O\n\nTokyo B-LOC\nNikkei B-MISC\naverage O\n-- O\n38,915.87 O\n( O\nDec O\n29/89 O\n) O\n\nFrankfurt B-LOC\nDAX-3O B-MISC\nindex O\n-- O\n2,583.49 O\n( O\nJul O\n5/96 O\n) O\n\nParis B-LOC\nCAC-40 B-MISC\nGeneral I-MISC\nindex O\n-- O\n2,355.93 O\n( O\nFeb O\n2/94 O\n) O\n\nSydney B-LOC\nAustralian B-MISC\nAll-Ordinaries I-MISC\nindex O\n-- O\n2,340.6 O\n( O\nFeb O\n3/94 O\n) O\n\nHong B-LOC\nKong I-LOC\nHang B-MISC\nSeng I-MISC\nindex O\n-- O\n12,201.09 O\n( O\nJan O\n4/94 O\n) O\n\n-DOCSTART- O\n\nUkraine B-LOC\nhails O\npeace O\nas O\nmarks O\nfive-year O\nindependence O\n. O\n\nRostislav B-PER\nKhotin I-PER\n\nKIEV B-LOC\n1996-08-23 O\n\nUkraine B-LOC\ncelebrates O\nfive O\nyears O\nof O\nindependence O\nfrom O\nKremlin B-LOC\nrule O\non O\nSaturday O\n, O\nhailing O\ncivil O\nand O\ninter-ethnic O\npeace O\nas O\nits O\nmain O\npost-Soviet B-MISC\nachievement O\n. O\n\nUkraine B-LOC\n's O\ndeclaration O\nof O\nindependence O\nin O\n1991 O\n, O\nbacked O\nnine-to-one O\nby O\na O\nreferendum O\nin O\nDecember O\nof O\nthat O\nyear O\n, O\neffectively O\ndealt O\na O\ndeath O\nblow O\nto O\nthe O\nSoviet B-MISC\nempire O\nand O\nended O\nmore O\nthan O\nthree O\ncenturies O\nof O\nrule O\nfrom O\nMoscow B-LOC\n. O\n\nUkraine B-LOC\n, O\nwith O\na O\nRussian B-MISC\ncommunity O\nof O\n11 O\nmillion O\npeople O\n-- O\nthe O\nworld O\n's O\nlargest O\noutside O\nRussia B-LOC\n-- O\nhas O\navoided O\nconflicts O\nlike O\nthose O\nin O\nRussia B-LOC\n's O\nChechnya B-LOC\n, O\nneighbouring O\nMoldova B-LOC\n, O\nand O\nthe O\nformer O\nSoviet B-MISC\nrepublics O\nof O\nGeorgia B-LOC\n, O\nAzerbaijan B-LOC\nand O\nTajikistan B-LOC\n. O\n\n\" O\nUkraine B-LOC\n's O\nbiggest O\nachievements O\nfor O\nfive O\nyears O\nare O\nthe O\npreservation O\nof O\ncivil O\npeace O\nand O\ninter-ethnic O\nharmony O\n, O\n\" O\nPresident O\nLeonid B-PER\nKuchma I-PER\nsaid O\nin O\ntelevised O\nstatement O\nthis O\nweek O\n. O\n\n\" O\nUnlike O\nmany O\nother O\npost-Soviet B-MISC\ncountries O\nwe O\nwere O\nable O\nto O\ndeal O\nwith O\nconflict O\nsituations O\nin O\na O\npeaceful O\nand O\ncivilised O\nway O\n. O\n\" O\n\nBut O\nindependence O\nwas O\ninitially O\naccompanied O\nby O\nhyper-inflation O\nand O\neconomic O\ncollapse O\n, O\nalthough O\nthere O\nare O\nsigns O\nof O\na O\nturnaround O\n. O\n\nInflation O\n-- O\na O\nhyper-inflationary O\n10,300 O\npercent O\na O\nyear O\nin O\n1993 O\n-- O\nwas O\na O\nrespectable O\n0.1 O\npercent O\na O\nmonth O\nin O\nJune O\nand O\nJuly O\nand O\nthe O\neconomy O\nhas O\njust O\nbegun O\nto O\ngrow O\n. O\n\nKuchma B-PER\ntold O\na O\nsolemn O\nceremony O\nat O\nthe O\nUkraina B-LOC\nPalace I-LOC\non O\nFriday O\nthat O\n\" O\nthere O\nwas O\na O\nturning O\npoint O\n\" O\nin O\nreforms O\nand O\nthat O\nhe O\nexpected O\na O\nrise O\nin O\nthe O\nstandard O\nof O\nliving O\nin O\nthe O\nnear O\nfuture O\n. O\n\n\" O\nThere O\nis O\nno O\ndoubt O\nthat O\neconomic O\ngrowth O\nhas O\nalready O\nstarted O\n, O\n\" O\nsaid O\nAdelbert B-PER\nKnobl I-PER\n, O\nhead O\nof O\nthe O\nInternational B-ORG\nMonetary I-ORG\nFund I-ORG\n's O\nmission O\nin O\nUkraine B-LOC\n. O\n\" O\n\nThe O\nnational O\nbank O\nand O\nthe O\ngovernment O\nhave O\nevery O\nreason O\nto O\nbe O\nproud O\nof O\ntheir O\nefforts O\n. O\n\" O\n\nCentral O\nbank O\nofficials O\nsaid O\non O\nThursday O\nthat O\na O\nmuch-postponed O\nhryvna O\ncurrency O\nwould O\n\" O\ndefinitely O\n\" O\nbe O\nintroduced O\nbefore O\nthe O\nend O\nof O\nthis O\nyear O\n. O\n\nIt O\nwill O\nreplace O\nthe O\ninterim O\nkarbovanets O\ncurrency O\n, O\nwhich O\nwas O\nintroduced O\nat O\npar O\nto O\nthe O\nRussian B-MISC\nrouble O\nin O\n1992 O\nbut O\nnow O\ntrades O\nat O\nalmost O\n33 O\nkarbovanets O\nper O\nrouble O\n. O\n\nUkraine B-LOC\nhas O\nrepeatedly O\npromised O\nto O\nintroduce O\nthe O\nhryvna O\nbut O\nhad O\nto O\npostpone O\nthe O\nplans O\nbecause O\nof O\neconomic O\nproblems O\n. O\n\nProud O\nof O\nits O\nrecord O\nin O\npromptly O\njoining O\nboth O\nthe O\nCouncil B-ORG\nof I-ORG\nEurope I-ORG\nand O\nNATO B-ORG\n's O\nPartnership B-MISC\nfor I-MISC\nPeace I-MISC\n, O\nUkraine B-LOC\ncaused O\na O\nforeign O\npolicy O\nwrangle O\nthis O\nweek O\n, O\noffending O\nChina B-LOC\nby O\nallowing O\na O\nTaiwanese B-MISC\nminister O\nto O\nappear O\non O\na O\npublic O\n, O\nif O\nunofficial O\nvisit O\n. O\n\nChina B-LOC\ncancelled O\na O\nvisit O\nby O\na O\ntop-level O\ndelegation O\nin O\nprotest O\n. O\n\nKiev B-LOC\n's O\nForeign O\nMinister O\nHennady B-PER\nUdovenko I-PER\nsaid O\nBeijing B-LOC\nwas O\noverreacting O\n. O\n\nBut O\nUkraine B-LOC\n, O\nseeing O\nitself O\nas O\na O\nbridge O\nbetween O\nRussia B-LOC\nand O\nthe O\nrapidly O\nWesternising B-MISC\ncountries O\nof O\neastern O\nEurope B-LOC\n, O\nis O\nlooking O\nWest O\nas O\nwell O\nas O\nEast O\n. O\n\n\" O\nThe O\nstrategic O\naim O\nof O\nEuropean B-MISC\nintegration O\nshould O\nnot O\nin O\nany O\nway O\ndamage O\nUkraine B-LOC\n's O\ninterests O\nin O\npost-Soviet B-MISC\nareas O\n. O\n\nRelations O\nwith O\nRussia B-LOC\n, O\nwhich O\nis O\nour O\nmain O\npartner O\n, O\nhave O\ngreat O\nimportance O\n, O\n\" O\nKuchma B-PER\nsaid O\n. O\n\n\" O\nBut O\nUkraine B-LOC\ncannot O\nbe O\neconomically O\noriented O\non O\nRussia B-LOC\n, O\neven O\nthough O\nthose O\nin O\nsome O\ncircles O\npush O\nus O\nto O\ndo O\nthat O\n. O\n\" O\n\nKuchma B-PER\nhas O\nsaid O\nKiev B-LOC\nwants O\nmembership O\nof O\nthe O\nEuropean B-ORG\nUnion I-ORG\n, O\nassociate O\nmembership O\nof O\nthe O\nWestern B-ORG\nEuropean I-ORG\nUnion I-ORG\ndefence O\ngrouping O\nand O\nto O\nmove O\ncloser O\nto O\nNATO B-ORG\n. O\n\nA O\nmessage O\nfrom O\nthe O\nWest O\nthis O\nweek O\nfrom O\nU.S. B-LOC\nPresident O\nBill B-PER\nClinton I-PER\ncongratulated O\nUkraine B-LOC\non O\nthe O\nanniversary O\n, O\npromising O\nto O\nsupport O\nmarket O\nreforms O\nand O\npraising O\nUkraine B-LOC\nas O\na O\n\" O\nstabilising O\nfactor O\n\" O\nin O\na O\nunited O\nEurope B-LOC\n. O\n\n-DOCSTART- O\n\nOldest O\nAlbania B-LOC\nbook O\ndisappears O\nfrom O\nVatican B-LOC\n- O\npaper O\n. O\n\nTIRANA B-LOC\n1996-08-23 O\n\nA O\n16th-century O\ndocument O\n, O\nthe O\nearliest O\ncomplete O\nexample O\nof O\nwritten O\nAlbanian B-MISC\n, O\nhas O\ndisappeared O\nfrom O\nthe O\nVatican B-LOC\narchives O\n, O\nan O\nAlbanian B-MISC\nnewspaper O\nsaid O\non O\nFriday O\n. O\n\nGazeta B-ORG\nShqiptare I-ORG\nsaid O\nthe O\n\" O\nBook B-MISC\nof I-MISC\nMass I-MISC\n' O\n, O\nby O\nGjon B-PER\nBuzuku I-PER\n, O\ndating O\nfrom O\n1555 O\nand O\ndiscovered O\nin O\n1740 O\nin O\na O\nreligious O\nseminary O\nin O\nRome B-LOC\n, O\nwas O\nthe O\nfirst O\nmajor O\ndocument O\npublished O\nin O\nthe O\nAlbanian B-MISC\nlanguage O\n. O\n\n\" O\nWe O\nAlbanians B-MISC\n, O\nsons O\nof O\nBuzuku B-MISC\n, O\nbelieved O\nour O\nlanguage O\nhad O\na O\nwritten O\ndocument O\nbut O\nnow O\nwe O\ndo O\nnot O\nhave O\nit O\nany O\nmore O\n, O\n\" O\nlamented O\nscholar O\nMusa B-PER\nHamiti I-PER\n, O\ntold O\nof O\nthe O\nloss O\nby O\nthe O\nVatican B-LOC\nlibrary O\n. O\n\nTirana B-LOC\n's O\nnational O\nlibrary O\nhas O\nthree O\ncopies O\nof O\nthe O\n\" O\nBook B-MISC\nof I-MISC\nMass I-MISC\n' O\n. O\n\" O\n\nThere O\nis O\nnothing O\nleft O\nfor O\nus O\nbut O\nto O\nbe O\ngrateful O\nto O\ncivilisation O\nfor O\ninventing O\nphotocopies O\n, O\n\" O\nGazeta B-ORG\nShqiptare I-ORG\nsaid O\n. O\n\n-DOCSTART- O\n\nRussia B-LOC\nto O\nclamp O\ndown O\non O\nbarter O\ndeals O\n. O\n\nMOSCOW B-LOC\n1996-08-23 O\n\nRussian B-MISC\nofficials O\n, O\nkeen O\nto O\ncut O\ncapital O\nflight O\n, O\nwill O\nadopt O\ntight O\nmeasures O\nto O\ncut O\nbarter O\ndeals O\nin O\nforeign O\ntrade O\nto O\na O\nminimum O\n, O\na O\ncustoms O\nofficial O\nsaid O\non O\nFriday O\n. O\n\n\" O\nWe O\nhave O\nalways O\nbeen O\nconcerned O\nabout O\nbarter O\ndeals O\nwith O\nother O\ncountries O\n, O\nviewing O\nthem O\nas O\na O\ndisguised O\nkind O\nof O\ncapital O\nflight O\nfrom O\nRussia B-LOC\n, O\n\" O\nMarina B-PER\nVolkova I-PER\n, O\ndeputy O\nhead O\nof O\nthe O\ncurrency O\ndepartment O\nat O\nthe O\nState B-ORG\nCustoms I-ORG\nCommittee I-ORG\n, O\ntold O\nReuters B-ORG\n. O\n\nVolkova B-PER\nsaid O\nlast O\nyear O\ngoods O\nhad O\nbeen O\nexported O\nunder O\nmany O\nRussian B-MISC\nbarter O\ndeals O\n, O\nwith O\nnothing O\nimported O\nin O\nreturn O\n. O\n\nShe O\nsaid O\nthe O\ncost O\nof O\nsuch O\nunimported O\ngoods O\nwas O\n$ O\n1.10 O\nbillion O\nin O\n1995 O\n. O\n\nBarter O\ndeals O\nwere O\nworth O\n$ O\n4.9 O\nbillion O\nlast O\nyear O\n, O\nor O\nabout O\neight O\npercent O\nof O\nall O\nRussian B-MISC\nexports O\nestimated O\nat O\n$ O\n61.5 O\nbillion O\n, O\nshe O\nsaid O\n. O\n\n\" O\nThe O\ncost O\nof O\nexported O\ngoods O\nis O\ntoo O\noften O\nunderstated O\n, O\nso O\nthe O\nactual O\nshare O\nof O\nbarter O\ndeals O\nin O\nRussian B-MISC\nexports O\nand O\nthe O\namount O\nof O\nunimported O\ngoods O\nmay O\nbe O\neven O\nhigher O\n, O\n\" O\nVolkova B-PER\nsaid O\n. O\n\nA O\nfew O\ndays O\nago O\nRussian B-MISC\nPresident O\nBoris B-PER\nYeltsin I-PER\nissued O\na O\ndecree O\non O\nstate O\nregulation O\nof O\nforeign O\nbarter O\ndeals O\n, O\nand O\nVolkova B-PER\nsaid O\nthis O\n\" O\ncould O\nsubstantially O\nimprove O\nthe O\nsituation O\n\" O\n. O\n\nIn O\nline O\nwith O\nthe O\ndecree O\n, O\nwhich O\nwill O\ncome O\ninto O\nforce O\non O\nNovember O\n1 O\n, O\nall O\nRussian B-MISC\nbarter O\ntraders O\nwill O\nbe O\nobliged O\nto O\nimport O\ngoods O\nworth O\nthe O\ncost O\nof O\ntheir O\nexports O\nwithin O\n180 O\ndays O\n. O\n\n\" O\nIf O\ntraders O\nare O\nlate O\n, O\nthey O\nwill O\nhave O\nto O\npay O\nfines O\nworth O\nthe O\ncost O\nof O\ntheir O\nexported O\ngoods O\n, O\n\" O\nVolkova B-PER\nsaid O\n. O\n\nUnderstating O\nthe O\ncost O\nof O\nexported O\ngoods O\ncould O\nstill O\nbe O\na O\nloophole O\nfor O\nbarter O\ndealers O\n, O\nbut O\nVolkova B-PER\nsaid O\nthe O\nauthorities O\nare O\ncurrently O\n\" O\ntackling O\nthe O\ntechnicalities O\nof O\nthe O\nissue O\n\" O\n. O\n\nBarter O\nhas O\nalways O\nbeen O\na O\nfeature O\nof O\nthe O\nSoviet B-LOC\nUnion I-LOC\n's O\nforeign O\ntrade O\n, O\nbut O\nYeltsin B-PER\n's O\ndecrees O\nliberalising O\nforeign O\ntrade O\nin O\n1991-1992 O\nhas O\ngiven O\nbarter O\na O\nnew O\nimpetus O\n. O\n\nA O\nfew O\nyears O\nago O\n, O\nbarter O\ndeals O\naccounted O\nfor O\nup O\nto O\n25-30 O\npercent O\nof O\nRussian B-MISC\nexports O\nbecause O\n\" O\nthousands O\n( O\nof O\n) O\ntrade O\ncompanies O\nwhich O\npopped O\nup O\npreferred O\nbarter O\nin O\nthe O\nabsence O\nof O\nreliable O\nRussian B-MISC\nbanks O\nand O\nmoney O\ntransfer O\nsystems O\n\" O\n, O\nVolkova B-PER\nsaid O\n. O\n\n\" O\nNow O\nmany O\nRussian B-MISC\nbanks O\nare O\nstrong O\nand O\ncan O\nmake O\nvarious O\nsorts O\nof O\nmoney O\ntranfers O\n, O\nwhile O\nincompetent O\ntraders O\nare O\nbeing O\nousted O\nby O\nmore O\nexperienced O\nones O\n. O\n\nBut O\nthe O\ncurrent O\nshare O\nof O\nbarter O\ndeals O\nin O\nRussian B-MISC\nexports O\nis O\nstill O\nhigh O\n, O\n\" O\nshe O\nsaid O\n. O\n\n-- O\nDmitry B-PER\nSolovyov I-PER\n, O\nMoscow B-ORG\nNewsroom I-ORG\n, O\n+7095 O\n941 O\n8520 O\n\n-DOCSTART- O\n\nViacom B-ORG\nplans O\n\" O\nMission B-MISC\n\" O\nsequel O\n- O\nreport O\n. O\n\nLOS B-LOC\nANGELES I-LOC\n1996-08-22 O\n\nParamount B-ORG\nPictures I-ORG\nis O\ngoing O\nahead O\nwith O\na O\nsequel O\nto O\nthe O\nTom B-PER\nCruise I-PER\nblockbuster O\n, O\n\" O\nMission B-MISC\n: I-MISC\nImpossible I-MISC\n\" O\nand O\nhopes O\nto O\nrelease O\nit O\nin O\nthe O\nsummer O\nof O\n1998 O\n, O\nDaily B-ORG\nVariety I-ORG\nreported O\nin O\nits O\nFriday O\nedition O\n. O\n\nThe O\nbig-screen O\nversion O\nof O\nthe O\nspy O\nTV O\nseries O\nhas O\ngrossed O\n$ O\n175 O\nmillion O\ndomestically O\nsince O\nopening O\nMay O\n22 O\n, O\nand O\n$ O\n338 O\nmillion O\noverseas O\nso O\nfar O\n. O\n\nIt O\n's O\nthe O\nbiggest O\nsuccess O\nfor O\nViacom B-MISC\nInc-owned I-MISC\nParamount B-ORG\nsince O\n1994 O\n's O\n\" O\nForrest B-MISC\nGump I-MISC\n\" O\n. O\n\nHowever O\n, O\nmany O\ncritics O\ncomplained O\nits O\nplot O\nwas O\nincomprehensible O\n. O\n\nCruise B-PER\nwill O\nreprise O\nhis O\nroles O\nas O\nstar O\nand O\nco-producer O\n, O\nand O\nwill O\nsoon O\nmeet O\nAcademy B-MISC\nAward-winning I-MISC\nscreenwriter O\nWilliam B-PER\nGoldman I-PER\n, O\nwho O\nwill O\nwrite O\nthe O\nscript O\n, O\nthe O\nreport O\nsaid O\n. O\n\nIt O\nsaid O\n\" O\nMission B-MISC\n: I-MISC\nImpossible I-MISC\n\" O\ndirector O\nBrian B-PER\nDe I-PER\nPalma I-PER\nwould O\nhave O\nfirst O\ncrack O\nat O\nthe O\nsequel O\n, O\nthough O\nno O\ndeals O\nhave O\nbeen O\nmade O\nyet O\n. O\n\nGoldman B-PER\n, O\nwhose O\nOscars B-MISC\nwere O\nfor O\n\" O\nButch B-MISC\nCassidy I-MISC\nand I-MISC\nthe I-MISC\nSundance I-MISC\nKid I-MISC\n\" O\nand O\n\" O\nAll B-MISC\nthe I-MISC\nPresident I-MISC\n's I-MISC\nMen I-MISC\n\" O\n, O\nearlier O\nthis O\nsummer O\ncriticised O\nsome O\nof O\nthe O\nseason O\n's O\nblockbusters O\n. O\n\nHowever O\n, O\nhe O\nsingled O\nout O\n\" O\nMission B-MISC\n: I-MISC\nImpossible I-MISC\n\" O\nas O\nan O\nespecially O\nentertaining O\nmovie O\n, O\nDaily B-ORG\nVariety I-ORG\nsaid O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nCRAWLEY B-PER\nFORCED O\nTO O\nSIT O\nAND O\nWAIT O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nEngland B-LOC\nbatsman O\nJohn B-PER\nCrawley I-PER\nwas O\nforced O\nto O\nendure O\na O\nfrustrating O\ndelay O\nof O\nover O\nthree O\nhours O\nbefore O\nresuming O\nhis O\nquest O\nfor O\na O\nmaiden O\ntest O\ncentury O\nin O\nthe O\nthird O\ntest O\nagainst O\nPakistan B-LOC\non O\nFriday O\n. O\n\nHeavy O\novernight O\nrain O\nand O\nmorning O\ndrizzle O\nruled O\nout O\nany O\nplay O\nbefore O\nlunch O\non O\nthe O\nsecond O\nday O\nbut O\nan O\nimprovement O\nin O\nthe O\nweather O\nprompted O\nthe O\numpires O\nto O\nannounce O\na O\n1415 O\nlocal O\ntime O\n( O\n1315 O\nGMT B-MISC\n) O\nstart O\nin O\nthe O\nevent O\nof O\nno O\nfurther O\nrain O\n. O\n\nCrawley B-PER\n, O\nunbeaten O\non O\n94 O\novernight O\nin O\nan O\nEngland B-LOC\ntotal O\nof O\n278 O\nfor O\nsix O\n, O\nwas O\nspotted O\nstrumming O\na O\nguitar O\nin O\nthe O\ndressing-room O\nas O\nthe O\nOval B-LOC\nground O\nstaff O\ntook O\ncentre O\nstage O\n. O\n\nThere O\nwere O\nseveral O\ndamp O\npatches O\non O\nthe O\nsquare O\nand O\nthe O\noutfield O\nand O\nit O\nwas O\nstill O\nraining O\nwhen O\nthe O\nplayers O\ntook O\nan O\nearly O\nlunch O\nat O\n1230 O\nlocal O\ntime O\n( O\n1130 O\nGMT B-MISC\n) O\n. O\n\nWhen O\nbrighter O\nweather O\nfinally O\narrived O\n, O\nthe O\numpires O\nannounced O\na O\nrevised O\nfigure O\nof O\n67 O\novers O\nto O\nbe O\nbowled O\nwith O\nplay O\nextended O\nto O\nat O\nleast O\n1900 O\nlocal O\ntime O\n( O\n1800 O\nGMT B-MISC\n) O\n. O\n\n-DOCSTART- O\n\nMOTOR O\nRACING O\n- O\nBELGIAN B-MISC\nGRAND B-MISC\nPRIX I-MISC\nPRACTICE O\nTIMES O\n. O\n\nSPA-FRANCORCHAMPS B-LOC\n, O\nBelgium B-LOC\n1996-08-23 O\n\nLeading O\ntimes O\n\nafter O\nFriday O\n's O\nopening O\npractice O\nsessions O\nfor O\nSunday O\n's O\n\nBelgian B-MISC\nGrand B-MISC\nPrix I-MISC\nmotor O\nrace O\n: O\n\n1. O\nGerhard B-PER\nBerger I-PER\n( O\nAustria B-LOC\n) O\nBenetton B-ORG\n1 O\nminute O\n53.706 O\nseconds O\n\n2. O\nDavid B-PER\nCoulthard I-PER\n( O\nBritain B-LOC\n) O\nMcLaren B-ORG\n1:54.342 O\n\n3. O\nJacques B-PER\nVilleneuve I-PER\n( O\nCanada B-LOC\n) O\nWilliams B-ORG\n1:54.443 O\n\n4. O\nMika B-PER\nHakkinen I-PER\n( O\nFinland B-LOC\n) O\nMcLaren B-ORG\n1:54.754 O\n\n5. O\nHeinz-Harald B-PER\nFrentzen I-PER\n( O\nGermany B-LOC\n) O\n1:54.984 O\n\n6. O\nJean B-PER\nAlesi I-PER\n( O\nFrance B-LOC\n) O\nBenetton B-ORG\n1:55.101 O\n\n7. O\nDamon B-PER\nHill I-PER\n( O\nBritain B-LOC\n) O\nWilliams B-ORG\n1:55.281 O\n\n8. O\nMichael B-PER\nSchumacher I-PER\n( O\nGermany B-LOC\n) O\n1:55.333 O\n\n9. O\nMartin B-PER\nBrundle I-PER\n( O\nBritain B-LOC\n) O\nJordan B-ORG\n1:55.385 O\n\n10. O\nRubens B-PER\nBarrichello I-PER\n( O\nBrazil B-LOC\n) O\nJordan B-ORG\n1:55.645 O\n\n11. O\nJohnny B-PER\nHerbert I-PER\n( O\nBritain B-LOC\n) O\nSauber B-ORG\n1:56.318 O\n\n12. O\nOlivier B-PER\nPanis I-PER\n( O\nFrance B-LOC\n) O\nLigier B-ORG\n1:56.417 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nTOSHIBA B-MISC\nCLASSIC I-MISC\n. O\n\n[ O\nCORRECTED O\n05:30 O\nGMT B-MISC\n] O\n\nCARLSBAD B-LOC\n, O\nCalifornia B-LOC\n1996-08-22 O\n\nResults O\nfrom O\nthe O\n\n$ O\n450,000 O\nToshiba B-MISC\nClassic I-MISC\ntennis O\ntournament O\non O\nThursday O\n( O\nprefix O\n\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nQuarter-finals O\n\n2 O\n- O\nConchita B-PER\nMartinez I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nNathalie B-PER\nTauziat I-PER\n( O\nFrance B-LOC\n) O\n\n6-3 O\n6-4 O\n\nSecond O\nround O\n\n5 O\n- O\nGabriela B-PER\nSabatini I-PER\n( O\nArgentina B-LOC\n) O\nbeat O\nAsa B-PER\nCarlsson I-PER\n( O\nSweden B-LOC\n) O\n\n6-1 O\n7-5 O\n\nKatarina B-PER\nStudenikova I-PER\n( O\nSlovakia B-LOC\n) O\nbeat O\n6 O\n- O\nKarina B-PER\nHabsudova I-PER\n\n( O\nSlovakia B-LOC\n) O\n7-6 O\n( O\n7-4 O\n) O\n6-2 O\n\n( O\nCorrects O\nthat O\nHabsudova B-PER\nis O\nsixth O\nseed O\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nResults O\nof O\nEnglish B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatches O\non O\nFriday O\n: O\n\nPortsmouth B-ORG\n1 O\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\n2 O\n\nTranmere B-ORG\n3 O\nGrimsby B-ORG\n2 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSCOTTISH B-MISC\nTHIRD O\nDIVISION O\nRESULT O\n. O\n\nGLASGOW B-LOC\n1996-08-23 O\n\nResult O\nof O\na O\nScottish B-MISC\nthird O\n\ndivision O\nsoccer O\nmatch O\non O\nFriday O\n: O\n\nEast B-ORG\nStirling I-ORG\n0 O\nAlbion B-ORG\n1 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLISH B-MISC\nCOUNTY I-MISC\nCHAMPIONSHIP I-MISC\nSCORES O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nClose O\nof O\nplay O\nscores O\nin O\nfour-day O\n\nEnglish B-MISC\nCounty I-MISC\nChampionship I-MISC\ncricket O\nmatches O\non O\nFriday O\n: O\n\nThird O\nday O\n\nAt O\nWeston-super-Mare B-LOC\n: O\nDurham B-ORG\n326 O\n( O\nD. B-PER\nCox I-PER\n95 O\nnot O\nout O\n, O\n\nS. B-PER\nCampbell I-PER\n69 O\n; O\nG. B-PER\nRose I-PER\n7-73 O\n) O\n. O\n\nSomerset B-ORG\n298-6 O\n( O\nM. B-PER\nLathwell I-PER\n85 O\n, O\n\nR. B-PER\nHarden I-PER\n65 O\n) O\n. O\n\nSecond O\nday O\n\nAt O\nColchester B-LOC\n: O\nGloucestershire B-ORG\n280 O\n( O\nJ. B-PER\nRussell I-PER\n63 O\n, O\nA. B-PER\nSymonds I-PER\n\n52 O\n; O\nA. B-PER\nCowan I-PER\n5-68 O\n) O\n. O\n\nEssex B-ORG\n194-0 O\n( O\nG. B-PER\nGooch I-PER\n105 O\nnot O\nout O\n, O\nD. B-PER\nRobinson I-PER\n\n72 O\nnot O\nout O\n) O\n. O\n\nAt O\nCardiff B-LOC\n: O\nKent B-ORG\n255-3 O\n( O\nD. B-PER\nFulton I-PER\n64 O\n, O\nM. B-PER\nWalker I-PER\n59 O\n, O\nC. B-PER\nHooper I-PER\n\n52 O\nnot O\nout O\n) O\nv O\nGlamorgan B-ORG\n. O\n\nAt O\nLeicester B-LOC\n: O\nLeicestershire B-ORG\n343-8 O\n( O\nP. B-PER\nSimmons I-PER\n108 O\n, O\nP. B-PER\nNixon I-PER\n\n67 O\nnot O\nout O\n) O\nv O\nHampshire B-ORG\n. O\n\nAt O\nNorthampton B-LOC\n: O\nSussex B-ORG\n389 O\n( O\nN. B-PER\nLenham I-PER\n145 O\n, O\nV. B-PER\nDrakes I-PER\n59 O\n, O\n\nA. B-PER\nWells I-PER\n51 O\n; O\nA. B-PER\nPenberthy I-PER\n4-36 O\n) O\n. O\n\nNorthamptonshire B-ORG\n160-4 O\n( O\nK. B-PER\nCurran I-PER\n\n79 O\nnot O\nout O\n) O\n. O\n\nAt O\nTrent B-LOC\nBridge I-LOC\n: O\nNottinghamshire B-ORG\n392-6 O\n( O\nG. B-PER\nArcher I-PER\n143 O\nnot O\n\nout O\n, O\nM. B-PER\nDowman I-PER\n107 O\n) O\nv O\nSurrey B-ORG\n. O\n\nAt O\nWorcester B-LOC\n: O\nWarwickshire B-ORG\n310 O\n( O\nA. B-PER\nGiles I-PER\n83 O\n, O\nT. B-PER\nMunton I-PER\n54 O\nnot O\n\nout O\n, O\nW. B-PER\nKhan I-PER\n52 O\n; O\nR. B-PER\nIllingworth I-PER\n4-54 O\n, O\nS. B-PER\nLampitt I-PER\n4-90 O\n) O\n. O\n\nWorcestershire B-ORG\n10-0 O\n. O\n\nAt O\nHeadingley B-LOC\n: O\nYorkshire B-ORG\n529-8 O\ndeclared O\n( O\nC. B-PER\nWhite I-PER\n181 O\n, O\n\nR. B-PER\nBlakey I-PER\n109 O\nnot O\nout O\n, O\nM. B-PER\nMoxon I-PER\n66 O\n, O\nM. B-PER\nVaughan I-PER\n57 O\n) O\n. O\n\nLancashire B-ORG\n\n162-4 O\n( O\nN. B-PER\nFairbrother I-PER\n53 O\nnot O\nout O\n) O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPOLLOCK B-PER\nHOPES O\nFOR O\nRETURN O\nTO O\nWARWICKSHIRE B-ORG\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nSouth B-MISC\nAfrican I-MISC\nall-rounder O\nShaun B-PER\nPollock I-PER\n, O\nforced O\nto O\ncut O\nshort O\nhis O\nfirst O\nseason O\nwith O\nWarwickshire B-ORG\nto O\nhave O\nankle O\nsurgery O\n, O\nhas O\ntold O\nthe O\nEnglish B-MISC\ncounty O\nhe O\nwould O\nlike O\nto O\nreturn O\nlater O\nin O\nhis O\ncareer O\n. O\n\nPollock B-PER\n, O\nwho O\nreturns O\nhome O\na O\nmonth O\nearly O\nnext O\nweek O\n, O\nsaid O\n: O\n\" O\nI O\nwould O\nlike O\nto O\ncome O\nback O\nand O\nplay O\ncounty O\ncricket O\nin O\nthe O\nfuture O\nand O\nI O\ndo O\nn't O\nthink O\nI O\nwould O\nlike O\nto O\nswap O\ncounties O\n. O\n\" O\n\nExplaining O\nhis O\npremature O\ndeparture O\nwas O\nunavoidable O\n, O\nPollock B-PER\nsaid O\n: O\n\" O\nI O\nhave O\nbeen O\ncarrying O\nthe O\ninjury O\nfor O\na O\nwhile O\nand O\nI O\nhope O\nthat O\nby O\nhaving O\nthe O\nsurgery O\nnow O\nI O\nwill O\nbe O\nable O\nto O\nlast O\nout O\nthe O\nnew O\nseason O\nback O\nhome O\n. O\n\" O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nV O\nPAKISTAN B-LOC\nFINAL O\nTEST O\nSCOREBOARD O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nScoreboard O\non O\nthe O\nsecond O\nday O\nof O\n\nthe O\nthird O\nand O\nfinal O\ntest O\nbetween O\nEngland B-LOC\nand O\nPakistan B-LOC\nat O\nThe B-LOC\n\nOval B-LOC\non O\nFriday O\n: O\n\nEngland B-LOC\nfirst O\ninnings O\n\nM. B-PER\nAtherton I-PER\nb O\nWaqar B-PER\nYounis I-PER\n31 O\n\nA. B-PER\nStewart I-PER\nb O\nMushtaq B-PER\nAhmed I-PER\n44 O\n\nN. B-PER\nHussain I-PER\nc O\nSaeed B-PER\nAnwar I-PER\nb O\nWaqar B-PER\nYounis I-PER\n12 O\n\nG. B-PER\nThorpe I-PER\nlbw O\nb O\nMohammad B-PER\nAkram I-PER\n54 O\n\nJ. B-PER\nCrawley I-PER\nb O\nWaqar B-PER\nYounis I-PER\n106 O\n\nN. B-PER\nKnight I-PER\nb O\nMushtaq B-PER\nAhmed I-PER\n17 O\n\nC. B-PER\nLewis I-PER\nb O\nWasim B-PER\nAkram I-PER\n5 O\n\nI. B-PER\nSalisbury I-PER\nc O\nInzamam-ul-Haq B-PER\nb O\nWasim B-PER\nAkram I-PER\n5 O\n\nD. B-PER\nCork I-PER\nc O\nMoin B-PER\nKhan I-PER\nb O\nWaqar B-PER\nYounis I-PER\n0 O\n\nR. B-PER\nCroft I-PER\nnot O\nout O\n5 O\n\nA. B-PER\nMullally I-PER\nb O\nWasim B-PER\nAkram I-PER\n24 O\n\nExtras O\n( O\nlb-12 O\nw-1 O\nnb-10 O\n) O\n23 O\n\nTotal O\n326 O\n\nFall O\nof O\nwickets O\n: O\n1-64 O\n2-85 O\n3-116 O\n4-205 O\n5-248 O\n6-273 O\n7-283 O\n\n8-284 O\n9-295 O\n\nBowling O\n: O\nWasim B-PER\nAkram I-PER\n29.2-9-83-3 O\n, O\nWaqar B-PER\nYounis I-PER\n25-6-95-4 O\n, O\n\nMohammad B-PER\nAkram I-PER\n12-1-41-1 O\n, O\nMushtaq B-PER\nAhmed I-PER\n27-5-78-2 O\n, O\nAamir B-PER\nSohail I-PER\n\n6-1-17-0 O\n\nPakistan B-LOC\nfirst O\ninnings O\n\nSaeed B-PER\nAnwar I-PER\nnot O\nout O\n116 O\n\nAamir B-PER\nSohail I-PER\nc O\nCork B-PER\nb O\nCroft B-PER\n46 O\n\nIjaz B-PER\nAhmed I-PER\nnot O\nout O\n58 O\n\nExtras O\n( O\nlb-1 O\nnb-8 O\n) O\n9 O\n\nTotal O\n( O\nfor O\none O\nwicket O\n) O\n229 O\n\nFall O\nof O\nwicket O\n- O\n1-106 O\n\nTo O\nbat O\n: O\nInzamam-ul-Haq B-PER\n, O\nSalim B-PER\nMalik I-PER\n, O\nAsif B-PER\nMujtaba I-PER\n, O\nWasim B-PER\n\nAkram B-PER\n, O\nMoin B-PER\nKhan I-PER\n, O\nMushtaq B-PER\nAhmed I-PER\n, O\nWaqar B-PER\nYounis I-PER\n, O\nMohammad B-PER\nAkam I-PER\n\nBowling O\n( O\nto O\ndate O\n) O\n: O\nLewis B-PER\n9-1-49-0 O\n, O\nMullally B-PER\n9-3-28-0 O\n, O\nCroft B-PER\n\n17-3-42-1 O\n, O\nCork B-PER\n7-1-38-0 O\n, O\nSalisbury B-PER\n14-0-71-0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\n326 O\nALL O\nOUT O\nV O\nPAKISTAN B-LOC\nIN O\nTHIRD O\nTEST O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nEngland B-LOC\nwere O\nall O\nout O\nfor O\n326 O\nin O\ntheir O\nfirst O\ninnings O\non O\nthe O\nsecond O\nday O\nof O\nthe O\nthird O\nand O\nfinal O\ntest O\nagainst O\nPakistan B-LOC\nat O\nThe B-LOC\nOval I-LOC\non O\nFriday O\n. O\n\nScore O\n: O\nEngland B-LOC\n326 O\n( O\nJ. B-PER\nCrawley I-PER\n106 O\n, O\nG. B-PER\nThorpe I-PER\n54 O\n. O\n\nWaqar B-PER\nYounis I-PER\n4-95 O\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSPONSORS O\nCASH O\nIN O\nON O\nRAVANELLI B-PER\n'S O\nSHIRT O\nDANCE O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nMiddlesbrough B-ORG\n's O\nItalian B-MISC\nstriker O\nFabrizio B-PER\nRavanelli I-PER\nis O\nto O\nwear O\nhis O\nteam O\nsponsor O\n's O\nname O\non O\nthe O\ninside O\nof O\nhis O\nshirt O\nso O\nit O\ncan O\nbe O\nseen O\nwhen O\nhe O\nscores O\n. O\n\nEvery O\ntime O\nhe O\nfinds O\nthe O\nnet O\n, O\nthe O\ngrey-haired O\nforward O\npulls O\nhis O\nshirtfront O\nover O\nhis O\nhead O\nas O\nhe O\nruns O\nto O\nsalute O\nthe O\nfans O\n, O\nand O\nMiddlesbrough B-ORG\n's O\nsponsors O\nwant O\nto O\ncash O\nin O\non O\nthe O\nspectacle O\n. O\n\n\" O\nHaving O\nseen O\nRavanelli B-PER\ncelebrate O\nhis O\ngoals O\n... O\n\nwe O\nthought O\nit O\nwould O\nbe O\nfun O\nto O\nhave O\n( O\nthe O\nname O\n) O\non O\nthe O\ninside O\nof O\nhis O\nshirt O\n, O\n\" O\na O\nspokesman O\nfor O\nthe O\nsponsors O\nsaid O\n. O\n\n\" O\nIt O\nwill O\ngive O\nthe O\nfans O\nsomething O\nelse O\nto O\nlook O\nat O\nbesides O\nhis O\nchest O\n. O\n\" O\n\nRavanelli B-PER\naggravated O\na O\nfoot O\ninjury O\nin O\nthe O\n1-0 O\ndefeat O\nat O\nChelsea B-ORG\non O\nWednesday O\nand O\nwas O\ngiven O\nonly O\nan O\neven O\nchance O\nof O\nplaying O\nat O\nNottingham B-LOC\nForest I-LOC\non O\nSaturday O\nby O\nhis O\nmanager O\nBryan B-PER\nRobson I-PER\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nAUSTRALIANS B-MISC\nADVANCE O\nAT O\nCANADIAN B-MISC\nOPEN I-MISC\n. O\n\nTORONTO B-LOC\n1996-08-22 O\n\nIt O\nwas O\nAustralia B-MISC\nDay I-MISC\nat O\nthe O\n$ O\n2 O\nmillion O\nCanadian B-MISC\nOpen I-MISC\non O\nThursday O\nas O\nthree O\nAussies B-MISC\nreached O\nthe O\nquarter-finals O\nwith O\nstraight-set O\nvictories O\n. O\n\nUnseeded O\nPatrick B-PER\nRafter I-PER\nrecorded O\nthe O\nmost O\nnoteworthy O\nresult O\nas O\nhe O\nupset O\nsixth-seeded O\nAmerican B-MISC\nMaliVai B-PER\nWashington I-PER\n6-2 O\n6-1 O\nin O\njust O\n50 O\nminutes O\n. O\n\nTodd B-PER\nWoodbridge I-PER\n, O\nwho O\ndefeated O\nCanadian B-MISC\nDaniel B-PER\nNestor I-PER\n7-6 O\n( O\n7-2 O\n) O\n7-6 O\n( O\n7-4 O\n) O\n, O\nand O\nMark B-PER\nPhilippoussis I-PER\n, O\na O\n6-3 O\n6-4 O\nwinner O\nover O\nBohdan B-PER\nUlihrach I-PER\nof O\nthe O\nCzech B-LOC\nRepublic I-LOC\n, O\nalso O\nadvanced O\nand O\nwill O\nmeet O\nin O\nFriday O\n's O\nquarter-finals O\n. O\n\nThird-seeded O\nWayne B-PER\nFerreira I-PER\nof O\nSouth B-LOC\nAfrica I-LOC\ndefeated O\nTim B-PER\nHenman I-PER\nof O\nBritain B-LOC\n6-4 O\n6-4 O\nafter O\na O\nthree-hour O\nevening O\nrain O\ndelay O\nand O\nfifth-seeded O\nThomas B-PER\nEnqvist I-PER\nof O\nSweden B-LOC\nwon O\nhis O\nthird-round O\nmatch O\n, O\neliminating O\nPetr B-PER\nKorda I-PER\nof O\nthe O\nCzech B-LOC\nRepublic I-LOC\n6-3 O\n6-4 O\n. O\n\nFerreira B-PER\nand O\nEnqvist B-PER\nplay O\nin O\na O\nFriday O\nnight O\nquarter-final O\n. O\n\nTwo O\nAmericans B-MISC\n, O\nseventh O\nseed O\nTodd B-PER\nMartin I-PER\nand O\nunseeded O\nAlex B-PER\nO'Brien I-PER\n, O\nwill O\nmeet O\non O\nFriday O\nafter O\nwinning O\nmatches O\non O\nThursday O\n. O\n\nMartin B-PER\novercame O\nCedric B-PER\nPioline I-PER\nof O\nFrance B-LOC\n2-6 O\n6-2 O\n6-4 O\nand O\nO'Brien B-PER\nbeat O\nMikael B-PER\nTillstrom I-PER\nof O\nSweden B-LOC\n6-3 O\n2-6 O\n6-3 O\n. O\n\n\" O\nIf O\nyou O\nreally O\nlook O\nat O\nthe O\nmatch O\n, O\n\" O\nsaid O\nthe O\n12th-ranked O\nWashington B-PER\nafter O\nlosing O\nto O\nthe O\n70th-ranked O\nRafter B-PER\n, O\n\" O\nI O\nnever O\nreally O\ngot O\na O\nchance O\nto O\nplay O\nbecause O\nhe O\nwas O\nserving O\nbig O\nand O\ngetting O\nin O\nclose O\nto O\nthe O\nnet O\n. O\n\n\" O\nHe O\nwas O\nalso O\nable O\nto O\nhandle O\nmy O\nserve O\npretty O\neasily O\nbecause O\nmy O\n( O\nfirst O\n) O\nservice O\npercentage O\nwas O\nonly O\nin O\nthe O\n40s O\n. O\n\nPut O\nthose O\ntwo O\nthings O\ntogether O\nand O\nyou O\nget O\na O\nloss O\n. O\n\" O\n\nRafter B-PER\nmissed O\n10 O\nweeks O\nafter O\nwrist O\nsurgery O\nearlier O\nthis O\nyear O\nand O\nthe O\ntime O\naway O\nfrom O\ntennis O\nhas O\ngiven O\nhim O\na O\nnew O\nperspective O\n. O\n\n\" O\nBefore O\nwhen O\nI O\nwas O\non O\ntour O\n, O\nI O\nalways O\nfelt O\nI O\nhad O\nto O\nbe O\nin O\nbed O\nby O\n9:30 O\nor O\n10 O\no'clock O\nand O\nI O\nhad O\nto O\nbe O\nup O\nat O\na O\ncertain O\ntime O\n, O\n\" O\nRafter B-PER\nsaid O\n. O\n\" O\n\nNow O\nI O\ncan O\ngo O\nto O\nbed O\nat O\nat O\nmidnight O\nor O\nwake O\nup O\nat O\nseven O\nin O\nthe O\nmorning O\n. O\n\nI O\njust O\ndo O\nn't O\nhave O\nas O\nmany O\nset O\nroutines O\nand O\nit O\n's O\nmade O\nme O\na O\nhappier O\nperson O\n. O\n\" O\n\nMartin B-PER\nwas O\npleased O\nwith O\nhis O\nvictory O\nover O\nPioline B-PER\n, O\nhis O\nfirst O\nin O\nfive O\nmeetings O\nwith O\nthe O\n11th-ranked O\nFrenchman B-MISC\n. O\n\" O\n\nIt O\n's O\nalways O\ndifficult O\nto O\nwin O\na O\nmatch O\nwhen O\nyou O\nlose O\nthe O\nfirst O\nset O\n, O\nespecially O\nagainst O\nsomeone O\nyou O\nhave O\nnever O\nbeaten O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nI O\ngot O\nmore O\naggressive O\nin O\nthe O\nsecond O\nand O\nthird O\nsets O\nand O\nthe O\nwind O\npicked O\nup O\nand O\nthat O\nalso O\naffected O\nthings O\nbecause O\nCedric B-PER\ndefinitely O\nwent O\noff O\na O\nlittle O\nbit O\n. O\n\" O\n\nThe O\n26-year-old O\nO'Brien B-PER\n, O\nwho O\nwon O\nthe O\nATP B-MISC\nTour I-MISC\nstop O\nin O\nNew B-LOC\nHaven I-LOC\nlast O\nweek O\n, O\nhas O\nnow O\nwon O\n18 O\nof O\nhis O\nlast O\n20 O\nmatches O\n, O\ndating O\nback O\nto O\nqualifying O\nrounds O\nin O\nLos B-LOC\nAngeles I-LOC\nin O\nlate O\nJuly O\n. O\n\nHe O\nranks O\n76th O\nafter O\nbeing O\n285th O\nfour O\nweeks O\nago O\n. O\n\n\" O\nI O\nfeel O\nI O\n'm O\nhitting O\nthe O\nball O\nwell O\neven O\nthough O\nI O\n'm O\nhaving O\nmore O\nmental O\nletdowns O\nthan O\nI O\ndid O\nlast O\nweek O\n, O\n\" O\nO'Brien B-PER\nsaid O\n. O\n\" O\n\nBut O\nI O\n'm O\nstill O\ncompeting O\nwell O\n. O\n\" O\n\n\" O\nI O\ngot O\na O\nlot O\nof O\nfirst O\nserves O\nin O\n, O\n\" O\nsaid O\nEnqvist B-PER\nabout O\nhis O\nvictory O\nover O\nKorda B-PER\n. O\n\" O\n\nI O\ndid O\nn't O\nmiss O\nthat O\nmany O\nshots O\nand O\nhe O\nwas O\nmaking O\nthe O\nmistakes O\n. O\n\" O\n\nStill O\nmarvelling O\nat O\nan O\nexciting O\n64-stroke O\nrally O\nhe O\nwon O\nin O\nthe O\nlast O\ngame O\nof O\nhis O\nsecond-round O\nmatch O\nagainst O\nJavier B-PER\nSanchez I-PER\nof O\nSpain B-LOC\non O\nTuesday O\n, O\nEnqvist B-PER\njoked O\n, O\n\" O\nToday O\nagainst O\nPetr B-PER\nthere O\nwere O\nabout O\n64 O\nstrokes O\nin O\nthe O\nwhole O\nmatch O\n. O\n\nIt O\nwas O\nmostly O\nshort O\npoints O\n. O\n\" O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nCANADIAN B-MISC\nOPEN I-MISC\n. O\n\nTORONTO B-LOC\n1996-08-22 O\n\nResults O\nfrom O\nthe O\nCanadian B-MISC\nOpen I-MISC\n\ntennis O\ntournament O\non O\nThursday O\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nThird O\nround O\n\n3 O\n- O\nWayne B-PER\nFerreira I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\nTim B-PER\nHenman I-PER\n( O\nBritain B-LOC\n) O\n6-4 O\n\n6-4 O\n\n4 O\n- O\nMarcelo B-PER\nRios I-PER\n( O\nChile B-LOC\n) O\nbeat O\nDaniel B-PER\nVacek I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n6-4 O\n\n6-3 O\n\n5 O\n- O\nThomas B-PER\nEnqvist I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nPetr B-PER\nKorda I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n\n6-3 O\n6-4 O\n\nPatrick B-PER\nRafter I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\n6 O\n- O\nMaliVai B-PER\nWashington I-PER\n( O\nU.S. B-LOC\n) O\n\n6-2 O\n6-1 O\n\n7 O\n- O\nTodd B-PER\nMartin I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\n9 O\n- O\nCedric B-PER\nPioline I-PER\n( O\nFrance B-LOC\n) O\n2-6 O\n6-2 O\n\n6-4 O\n\nMark B-PER\nPhilippoussis I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nBohdan B-PER\nUlihrach I-PER\n( O\nCzech B-LOC\n\nRepublic B-LOC\n) O\n6-3 O\n6-4 O\n\nAlex B-PER\nO'Brien I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nMikael B-PER\nTillstrom I-PER\n( O\nSweden B-LOC\n) O\n6-3 O\n2-6 O\n\n6-3 O\n\nTodd B-PER\nWoodbridge I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nDaniel B-PER\nNestor I-PER\n( O\nCanada B-LOC\n) O\n7-6 O\n\n( O\n7-2 O\n) O\n7-6 O\n( O\n7-4 O\n) O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nMULDER B-PER\nOUT O\nOF O\nSECOND O\nTEST O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-23 O\n\nCentre O\nJapie B-PER\nMulder I-PER\nhas O\nbeen O\nruled O\nout O\nof O\nSouth B-LOC\nAfrica I-LOC\n's O\nteam O\nfor O\nthe O\nsecond O\ntest O\nagainst O\nNew B-LOC\nZealand I-LOC\nin O\nPretoria B-LOC\non O\nSaturday O\n. O\n\nMulder B-PER\nmissed O\nthe O\nfirst O\ntest O\nin O\nDurban B-LOC\nwith O\nback O\nspasms O\nand O\nfailed O\na O\nfitness O\ncheck O\non O\nThursday O\n. O\n\nBut O\nnew O\nSpringbok B-ORG\nskipper O\nGary B-PER\nTeichmann I-PER\nhas O\nrecovered O\nfrom O\na O\nbruised O\nthigh O\nand O\nis O\nready O\nto O\nplay O\n, O\ncoach O\nAndre B-PER\nMarkgraaff I-PER\nsaid O\n. O\n\nMulder B-PER\n's O\nabsence O\nmeans O\nthat O\nNorthern B-ORG\nTransvaal I-ORG\ncentre O\nAndre B-PER\nSnyman I-PER\nshould O\nwin O\nhis O\nsecond O\ncap O\nalongside O\nprovincial O\ncolleague O\nDanie B-PER\nvan I-PER\nSchalkwyk I-PER\n. O\n\nWing O\nPieter B-PER\nHendriks I-PER\nis O\nexpected O\nto O\nretain O\nhis O\nplace O\n, O\nfollowing O\nspeculation O\nthat O\nSnyman B-PER\nwould O\nbe O\npicked O\nout O\nof O\nposition O\non O\nthe O\nwing O\n. O\n\nThe O\nline-up O\nwould O\nnot O\nbe O\nannounced O\nuntil O\nshortly O\nbefore O\nthe O\nstart O\n, O\nMarkgraaff B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nBADMINTON O\n- O\nMALAYSIAN B-MISC\nOPEN I-MISC\nBADMINTON O\nRESULTS O\n. O\n\nKUALA B-LOC\nLUMPUR I-LOC\n1996-08-23 O\n\nResults O\nin O\nthe O\nMalaysian B-MISC\n\nOpen B-MISC\nbadminton O\ntournament O\non O\nFriday O\n( O\nprefix O\nnumbers O\ndenote O\n\nseedings O\n) O\n: O\n\nMen O\n's O\nsingles O\n, O\nquarter-finals O\n\n2 O\n- O\nOng B-PER\nEwe I-PER\nHock I-PER\n( O\nMalaysia B-LOC\n) O\nbeat O\n5/8 O\n- O\nHu B-PER\nZhilan I-PER\n( O\nChina B-LOC\n) O\n15-2 O\n15-10 O\n\n9/16 O\n- O\nLuo B-PER\nYigang I-PER\n( O\nChina B-LOC\n) O\nbeat O\nJason B-PER\nWong I-PER\n( O\nMalaysia B-LOC\n) O\n15-5 O\n15-6 O\n\nIjaya B-PER\nIndra I-PER\n( O\nIndonesia B-LOC\n) O\nbeat O\nP. B-PER\nKantharoopan I-PER\n( O\nMalaysia B-LOC\n) O\n15-6 O\n5-4 O\n\n9/16 O\n- O\nChen B-PER\nGang I-PER\n( O\nChina B-LOC\n) O\nbeat O\n9/16 O\n- O\nHermawan B-PER\nSusanto I-PER\n( O\nIndonesia B-LOC\n) O\n\n15-9 O\n15-7 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nINJURED O\nCHANDA B-PER\nRUBIN I-PER\nOUT O\nOF O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-23 O\n\nPromising O\n10th-ranked O\nAmerican B-MISC\nChanda B-PER\nRubin I-PER\nhas O\npulled O\nout O\nof O\nthe O\nU.S. B-MISC\nOpen I-MISC\nTennis I-MISC\nChampionships I-MISC\nwith O\na O\nwrist O\ninjury O\n, O\ntournament O\nofficials O\nannounced O\n. O\n\nThe O\n20-year-old O\nRubin B-PER\n, O\nwho O\nwas O\nto O\nbe O\nseeded O\n11th O\n, O\nis O\nstill O\nsuffering O\nfrom O\ntendinitis O\nof O\nthe O\nright O\nwrist O\nthat O\nhas O\nkept O\nher O\nsidelined O\nin O\nrecent O\nmonths O\n. O\n\nRubin B-PER\n's O\nmisfortune O\nturned O\ninto O\na O\nvery O\nlucky O\nbreak O\nfor O\neighth-seeded O\nOlympic B-MISC\nchampion O\nLindsay B-PER\nDavenport I-PER\n. O\n\nDavenport B-PER\nhad O\ndrawn O\none O\nof O\nthe O\ntoughest O\nfirst-round O\nassignments O\nof O\nany O\nof O\nthe O\nseeded O\nplayers O\nin O\n17th-ranked O\nKarina B-PER\nHabsudova I-PER\nof O\nSlovakia B-LOC\n. O\n\nBut O\nas O\nthe O\nhighest-ranked O\nnon-seeded O\nplayer O\nin O\nthe O\ntournament O\n, O\nHabsudova B-PER\nwill O\nbe O\nmoved O\ninto O\nRubin B-PER\n's O\nslot O\nin O\nthe O\ndraw O\n, O\nwhile O\nDavenport B-PER\nwill O\nnow O\nget O\na O\nqualifier O\nin O\nthe O\nfirst O\nround O\n, O\naccording O\nto O\nU.S. B-MISC\nTennis I-MISC\nAssociation I-MISC\nofficials O\n. O\n\nRubin B-PER\nis O\nthe O\nthird O\nnotable O\nwithdrawal O\nfrom O\nthe O\nwomen O\n's O\ncompetition O\nafter O\n12th-ranked O\nformer O\nAustralian B-MISC\nOpen I-MISC\nchampion O\nMary B-PER\nPierce I-PER\nand O\n20th-ranked O\nWimbledon B-MISC\nsemifinalist O\nMeredith B-PER\nMcGrath I-PER\npulled O\nout O\nearlier O\nthis O\nweek O\nwith O\ninjuries O\n. O\n\nMen O\n's O\nAustralian B-MISC\nOpen I-MISC\nchampion O\nBoris B-PER\nBecker I-PER\nwill O\nalso O\nmiss O\nthe O\nyear O\n's O\nfinal O\nGrand B-MISC\nSlam I-MISC\nwith O\na O\nwrist O\ninjury O\n. O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nTHURSDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-23 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nThursday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n72 O\n54 O\n.571 O\n- O\n\nBALTIMORE B-ORG\n67 O\n59 O\n.532 O\n5 O\n\nBOSTON B-ORG\n64 O\n64 O\n.500 O\n9 O\n\nTORONTO B-ORG\n59 O\n69 O\n.461 O\n14 O\n\nDETROIT B-ORG\n45 O\n82 O\n.354 O\n27 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n76 O\n51 O\n.598 O\n- O\n\nCHICAGO B-ORG\n69 O\n60 O\n.535 O\n8 O\n\nMINNESOTA B-ORG\n63 O\n64 O\n.496 O\n13 O\n\nMILWAUKEE B-ORG\n60 O\n68 O\n.469 O\n16 O\n1/2 O\n\nKANSAS B-ORG\nCITY I-ORG\n58 O\n71 O\n.450 O\n19 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n74 O\n54 O\n.578 O\n- O\n\nSEATTLE B-ORG\n65 O\n61 O\n.516 O\n8 O\n\nOAKLAND B-ORG\n62 O\n68 O\n.477 O\n13 O\n\nCALIFORNIA B-ORG\n59 O\n68 O\n.465 O\n14 O\n1/2 O\n\nFRIDAY O\n, O\nAUGUST O\n23 O\nSCHEDULE O\n\nSEATTLE B-ORG\nAT O\nBOSTON B-LOC\n\nMILWAUKEE B-ORG\nAT O\nCLEVELAND B-LOC\n\nCALIFORNIA B-ORG\nAT O\nBALTIMORE B-LOC\n\nOAKLAND B-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nTORONTO B-ORG\nAT O\nCHICAGO B-LOC\n\nDETROIT B-ORG\nAT O\nKANSAS B-LOC\nCITY I-LOC\n\nTEXAS B-ORG\nAT O\nMINNESOTA B-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n79 O\n47 O\n.627 O\n- O\n\nMONTREAL B-ORG\n68 O\n58 O\n.540 O\n11 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n69 O\n.461 O\n21 O\n\nFLORIDA B-ORG\n58 O\n69 O\n.457 O\n21 O\n1/2 O\n\nPHILADELPHIA B-ORG\n52 O\n76 O\n.406 O\n28 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nHOUSTON B-ORG\n68 O\n60 O\n.531 O\n- O\n\nST B-ORG\nLOUIS I-ORG\n67 O\n60 O\n.528 O\n1/2 O\n\nCHICAGO B-ORG\n63 O\n62 O\n.504 O\n3 O\n1/2 O\n\nCINCINNATI B-ORG\n63 O\n62 O\n.504 O\n3 O\n1/2 O\n\nPITTSBURGH B-ORG\n54 O\n73 O\n.425 O\n13 O\n1/2 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n70 O\n59 O\n.543 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n67 O\n60 O\n.528 O\n2 O\n\nCOLORADO B-ORG\n66 O\n62 O\n.516 O\n3 O\n1/2 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n54 O\n71 O\n.432 O\n14 O\n\nFRIDAY O\n, O\nAUGUST O\n23 O\nSCHEDULE O\n\nCINCINNATI B-ORG\nAT O\nFLORIDA B-LOC\n( O\ndoubleheader O\n) O\n\nCHICAGO B-ORG\nAT O\nATLANTA B-LOC\n\nST B-ORG\nLOUIS I-ORG\nAT O\nHOUSTON B-LOC\n\nPITTSBURGH B-ORG\nAT O\nCOLORADO B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nLOS B-LOC\nANGELES I-LOC\n\nPHILADELPHIA B-ORG\nAT O\nSAN B-LOC\nDIEGO I-LOC\n\nMONTREAL B-ORG\nAT O\nSAN B-LOC\nFRANCISCO I-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nTHURSDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-23 O\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\n\nBaseball O\ngames O\nplayed O\non O\nThursday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nAmerican B-MISC\nLeague I-MISC\n\nBOSTON B-ORG\n2 O\nOakland B-ORG\n1 O\n\nSeattle B-ORG\n10 O\nBALTIMORE B-ORG\n3 O\n\nCalifornia B-ORG\n12 O\nNEW B-ORG\nYORK I-ORG\n3 O\n\nToronto B-ORG\n1 O\nCHICAGO B-ORG\n0 O\n( O\nin O\n6 O\n1/2 O\n) O\n\nDetroit B-ORG\n10 O\nKANSAS B-ORG\nCITY I-ORG\n3 O\n\nTexas B-ORG\n11 O\nMINNESOTA B-ORG\n2 O\n\nNational B-MISC\nLeague I-MISC\n\nCOLORADO B-ORG\n10 O\nSt B-ORG\nLouis I-ORG\n5 O\n\nCincinnati B-ORG\n3 O\nATLANTA B-ORG\n2 O\n( O\nin O\n13 O\n) O\n\nPittsburgh B-ORG\n8 O\nHOUSTON B-ORG\n6 O\n\nLOS B-ORG\nANGELES I-ORG\n8 O\nPhiladelphia B-ORG\n5 O\n\nMontreal B-ORG\n5 O\nSAN B-ORG\nFRANCISCO I-ORG\n4 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nSORRENTO B-PER\nHITS O\nSLAM O\nAS O\nSEATTLE B-ORG\nROUTS O\nORIOLES B-ORG\n. O\n\nBALTIMORE B-LOC\n1996-08-22 O\n\nFormer O\nOriole B-MISC\nJamie B-PER\nMoyer I-PER\nallowed O\ntwo O\nhits O\nover O\neight O\nscoreless O\ninnings O\nbefore O\ntiring O\nin O\nthe O\nninth O\nand O\nPaul B-PER\nSorrento I-PER\nadded O\nhis O\nthird O\ngrand O\nslam O\nof O\nthe O\nseason O\nas O\nthe O\nSeattle B-ORG\nMariners I-ORG\nrouted O\nBaltimore B-ORG\n10-3 O\nThursday O\n. O\n\nMoyer B-PER\n( O\n10-2 O\n) O\n, O\nwho O\nwas O\ntagged O\nfor O\na O\npair O\nof O\nhomers O\nby O\nMike B-PER\nDevereaux I-PER\nand O\nBrady B-PER\nAnderson I-PER\nand O\nthree O\nruns O\nin O\nthe O\nninth O\n, O\nwalked O\nnone O\nand O\nstruck O\nout O\ntwo O\n. O\n\nNorm B-PER\nCharlton I-PER\nretired O\nthe O\nfinal O\nthree O\nbatters O\nto O\nseal O\nthe O\nvictory O\n. O\n\nWith O\none O\nout O\nin O\nthe O\nfifth O\nKen B-PER\nGriffey I-PER\nJr I-PER\nand O\nEdgar B-PER\nMartinez I-PER\nstroked O\nback-to-back O\nsingles O\noff O\nOrioles B-ORG\nstarter O\nRocky B-PER\nCoppinger I-PER\n( O\n7-5 O\n) O\nand O\nJay B-PER\nBuhner I-PER\nwalked O\n. O\n\nSorrento B-PER\nfollowed O\nby O\nhitting O\na O\n1-2 O\npitch O\njust O\nover O\nthe O\nright-field O\nwall O\nfor O\na O\n7-0 O\nadvantage O\n. O\n\nRight O\nfielder O\nBobby B-PER\nBonilla I-PER\nwas O\nafter O\nthe O\nball O\n, O\nwhich O\nwas O\ntouched O\nby O\nfans O\nat O\nthe O\ntop O\nof O\nthe O\nscoreboard O\nin O\nright O\n. O\n\n\" O\nThings O\nfell O\nin O\nfor O\nus O\n, O\n\" O\nsaid O\nSorrento B-PER\n, O\nwho O\nhas O\nsix O\ncareer O\ngrand O\nslams O\nand O\nhit O\nthe O\nninth O\nof O\nthe O\nseason O\nfor O\nthe O\nMariners B-ORG\n. O\n\n\" O\nWe O\nhave O\nover O\na O\nmonth O\nleft O\n. O\n\nWe O\n've O\ngot O\nto O\nmake O\nup O\nsome O\nground O\n. O\n\" O\n\nIn O\nthe O\nAmerican B-MISC\nLeague I-MISC\nwild-card O\nrace O\n, O\nthe O\nMariners B-ORG\nare O\nthree O\ngames O\nbehind O\nthe O\nWhite B-ORG\nSox I-ORG\n, O\ntwo O\nbehind O\nBaltimore B-ORG\nand O\ntwo O\nahead O\nof O\nthe O\nRed B-ORG\nSox I-ORG\nheading O\ninto O\nBoston B-LOC\nfor O\na O\nweekend O\nseries O\n. O\n\nMoyer B-PER\nretired O\n11 O\nstraight O\nbatters O\nbetween O\nthe O\nthird O\nand O\nseventh O\ninnings O\nand O\nthrew O\ntwo O\nor O\nfewer O\npitches O\nto O\n11 O\nof O\nthe O\n29 O\nbatters O\nhe O\nfaced O\n. O\n\n\" O\nI O\nmade O\nsome O\nbad O\npitches O\nat O\nthe O\nend O\nbut O\nI O\n'm O\nnot O\ngoing O\nto O\ndwell O\non O\nit O\n. O\n\nWe O\nwon O\nthe O\ngame O\n, O\n\" O\nsaid O\nMoyer B-PER\n. O\n\nCoppinger B-PER\n( O\n7-5 O\n) O\nwas O\ntagged O\nfor O\neight O\nruns O\nand O\n10 O\nhits O\nin O\n4 O\n1/3 O\ninnings O\n. O\n\nOrioles B-ORG\nmanager O\nDavey B-PER\nJohnson I-PER\nmissed O\nthe O\ngame O\nafter O\nbeing O\nadmitted O\nto O\na O\nhospital O\nwith O\nan O\nirregular O\nheartbeat O\n. O\n\nBench O\ncoach O\nAndy B-PER\nEtchebarren I-PER\ntook O\nhis O\nplace O\n. O\n\nIn O\nBoston B-LOC\n, O\nTroy B-PER\nO'Leary I-PER\nhomered O\noff O\nthe O\nright-field O\nfoul O\npole O\nwith O\none O\nout O\nin O\nthe O\nbottom O\nof O\nthe O\nninth O\nand O\nthe O\nRed B-ORG\nSox I-ORG\nclimbed O\nto O\nthe O\n.500 O\nmark O\nfor O\nthe O\nfirst O\ntime O\nthis O\nseason O\nwith O\ntheir O\nfourth O\nstraight O\nvictory O\n, O\n2-1 O\nover O\nthe O\nOakland B-ORG\nAthletics I-ORG\n. O\n\nBoston B-ORG\nhas O\nwon O\n15 O\nof O\nits O\nlast O\n19 O\ngames O\n. O\n\nBoston B-ORG\n's O\nRoger B-PER\nClemens I-PER\n( O\n7-11 O\n) O\nwas O\none O\nout O\naway O\nfrom O\nhis O\nsecond O\nstraight O\nshutout O\nwhen O\npinch-hitter O\nMatt B-PER\nStairs I-PER\ntripled O\nover O\nthe O\nhead O\nof O\ncentre O\nfielder O\nLee B-PER\nTinsley I-PER\non O\nan O\n0-2 O\npitch O\nand O\npinch-hitter O\nTerry B-PER\nSteinbach I-PER\ndunked O\na O\nbroken-bat O\nsingle O\ninto O\nright O\nto O\nlift O\nOakland B-ORG\ninto O\na O\n1-1 O\ntie O\n. O\n\nThe O\nrun O\nbroke O\nClemens B-PER\n' O\n28-inning O\nshutout O\nstreak O\n, O\nlongest O\nin O\nthe O\nmajors O\nthis O\nseason O\n. O\n\nHe O\npitched O\nhis O\nfourth O\ncomplete O\ngame O\n, O\nallowing O\neight O\nhits O\nwith O\ntwo O\nwalks O\nand O\n11 O\nstrikeouts O\n. O\n\nReliever O\nMark B-PER\nAcre I-PER\n( O\n0-1 O\n) O\ntook O\nthe O\nloss O\n. O\n\nIn O\nNew B-LOC\nYork I-LOC\n, O\nGarret B-PER\nAnderson I-PER\nand O\nGary B-PER\nDiSarcina I-PER\ndrove O\nin O\ntwo O\nruns O\napiece O\nin O\na O\nfive-run O\nfirst O\ninning O\nand O\nJim B-PER\nEdmonds I-PER\nhighlighted O\na O\nsix-run O\nsixth O\nwith O\na O\nbases-loaded O\ndouble O\nas O\nthe O\nCalifornia B-ORG\nAngels I-ORG\ncoasted O\nto O\na O\n12-3 O\nvictory O\nover O\nthe O\nYankees B-ORG\nin O\nthe O\nrubber O\ngame O\nof O\ntheir O\nthree-game O\nseries O\n. O\n\nThe O\nAngels B-ORG\nbattered O\nKenny B-PER\nRogers I-PER\n( O\n10-7 O\n) O\nfor O\nfive O\nruns O\nin O\nthe O\nfirst O\n. O\n\nThe O\nYankees B-ORG\nhave O\nallowed O\nat O\nleast O\ntwo O\nruns O\nin O\nthe O\nfirst O\ninning O\nin O\nsix O\nstraight O\ngames O\n, O\ngetting O\noutscored O\n21-1 O\nin O\nthe O\nfirst O\ninning O\nin O\nthat O\nspan O\n. O\n\nChuck B-PER\nFinley I-PER\n( O\n12-12 O\n) O\nsnapped O\na O\nfour-game O\nlosing O\nstreak O\n. O\n\nIn O\nKansas B-LOC\nCity I-LOC\n, O\nTravis B-PER\nFryman I-PER\ndoubled O\nin O\nthe O\ngo-ahead O\nrun O\nin O\nthe O\nfifth O\nand O\nMelvin B-PER\nNieves I-PER\nand O\nDamion B-PER\nEasley I-PER\nbelted O\ntwo-run O\nhomers O\nas O\nthe O\nDetroit B-ORG\nTigers I-ORG\nclaimed O\na O\n10-3 O\nwin O\nover O\nthe O\nRoyals B-ORG\n, O\nhanding O\nthem O\ntheir O\nfifth O\nstraight O\nloss O\n. O\n\nThe O\nTigers B-ORG\nwon O\ntheir O\nthird O\nstraight O\nand O\nhalted O\na O\nseven-game O\nroad O\nlosing O\nstreak O\nbehind O\nJustin B-PER\nThompson I-PER\n( O\n1-2 O\n) O\n, O\nwho O\nearned O\nhis O\nfirst O\nmajor-league O\nwin O\n. O\n\nTim B-PER\nBelcher I-PER\n( O\n12-8 O\n) O\nwas O\ntagged O\nfor O\nsix O\nruns O\nand O\nnine O\nhits O\nin O\neight O\ninnings O\n. O\n\nAt O\nMinnesota B-LOC\n, O\nKen B-PER\nHill I-PER\nallowed O\ntwo O\nruns O\nen O\nroute O\nto O\nhis O\nsixth O\ncomplete O\ngame O\nof O\nthe O\nseason O\nand O\nRusty B-PER\nGreer I-PER\nadded O\nthree O\nhits O\n, O\nincluding O\na O\nhomer O\n, O\nand O\ntwo O\nRBI B-MISC\nas O\nthe O\nred-hot O\nTexas B-ORG\nRangers I-ORG\nrouted O\nthe O\nTwins B-ORG\n11-2 O\n. O\n\nThe O\nRangers B-ORG\n, O\nwho O\nwon O\nfor O\nthe O\n11th O\ntime O\nin O\ntheir O\nlast O\n13 O\ngames O\n, O\nhave O\nscored O\n45 O\nruns O\nin O\ntheir O\nlast O\nfive O\ncontests O\n. O\n\nHill B-PER\n( O\n14-7 O\n) O\nallowed O\n10 O\nhits O\n. O\n\nHe O\nhas O\nyielded O\njust O\nseven O\nruns O\nin O\nhis O\nlast O\nfour O\nstarts O\n, O\ncovering O\n33 O\n1/3 O\ninnings O\n. O\n\nIn O\nChicago B-LOC\n, O\nErik B-PER\nHanson I-PER\noutdueled O\nAlex B-PER\nFernandez I-PER\n, O\nand O\nJacob B-PER\nBrumfield I-PER\ndrove O\nin O\nOtis B-PER\nNixon I-PER\nwith O\nthe O\ngame O\n's O\nonly O\nrun O\nin O\nthe O\nsixth O\ninning O\nas O\nthe O\nToronto B-ORG\nBlue I-ORG\nJays I-ORG\nblanked O\nthe O\nWhite B-ORG\nSox I-ORG\n1-0 O\nin O\na O\ngame O\nshortened O\nto O\nsix O\ninnings O\ndue O\nto O\nrain O\n. O\n\nToronto B-ORG\nwon O\nits O\nfifth O\nstraight O\nand O\nhanded O\nthe O\nWhite B-ORG\nSox I-ORG\ntheir O\nseventh O\nloss O\nin O\nnine O\ngames O\n. O\n\nHanson B-PER\n( O\n11-15 O\n) O\nallowed O\nthree O\nhits O\n, O\nwalked O\nthree O\nand O\nstruck O\nout O\nfour O\nto O\nsnap O\na O\npersonal O\nthree-game O\nlosing O\nstreak O\n. O\n\nFernandez B-PER\n( O\n12-8 O\n) O\nscattered O\nsix O\nhits O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSPORTING B-ORG\nSTART O\nNEW O\nSEASON O\nWITH O\nA O\nWIN O\n. O\n\nLISBON B-LOC\n1996-08-23 O\n\nSporting B-ORG\n's O\nLuis B-PER\nMiguel I-PER\nPredrosa I-PER\nscored O\nthe O\nfirst O\ngoal O\nof O\nthe O\nnew O\nleague O\nseason O\nas O\nthe O\nLisbon B-LOC\nside O\ncruised O\nto O\na O\n3-1 O\naway O\nwin O\nover O\nSC B-ORG\nEspinho I-ORG\non O\nFriday O\n. O\n\nPredrosa B-PER\ndrilled O\na O\nright-foot O\nshot O\ninto O\nthe O\nback O\nof O\nthe O\nnet O\nafter O\n24 O\nminutes O\nto O\nset O\nSporting B-ORG\non O\nthe O\nway O\nto O\nvictory O\n. O\n\nAlthough O\nEspinho B-ORG\n's O\nNail B-PER\nBesirovic I-PER\nput O\nthe O\nhome O\nside O\nback O\non O\nterms O\nin O\nthe O\n35th O\nminute O\n, O\nSporting B-ORG\nquickly O\nrestored O\ntheir O\nlead O\n. O\n\nJose B-PER\nLuis I-PER\nVidigal I-PER\nscored O\nin O\nthe O\n38th O\nminute O\nand O\nMustapha B-PER\nHadji I-PER\nadded O\nthe O\nthird O\nin O\nthe O\n57th O\n. O\n\nThe O\ngame O\nwas O\nbrought O\nforward O\nfrom O\nSunday O\nwhen O\nreigning O\nchampions O\nPorto B-ORG\nand O\nLisbon B-ORG\nrivals O\nBenfica B-ORG\nplay O\ntheir O\nfirst O\ngames O\nof O\nthe O\nseason O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPORTUGUESE B-MISC\nFIRST O\nDIVISION O\nRESULT O\n. O\n\nLISBON B-LOC\n1996-08-23 O\n\nResult O\nof O\na O\nPortuguese B-MISC\nfirst O\n\ndivision O\nsoccer O\nmatch O\non O\nFriday O\n: O\n\nEspinho B-ORG\n1 O\nSporting B-ORG\n3 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nST B-ORG\nPAULI I-ORG\nTAKE O\nPOINT O\nWITH O\nLATE O\nFIGHTBACK O\n. O\n\nBONN B-LOC\n1996-08-23 O\n\nHamburg B-LOC\nside O\nSt B-ORG\nPauli I-ORG\n, O\ntipped O\nas O\nprime O\ncandidates O\nfor O\nrelegation O\n, O\nproduced O\na O\nstunning O\nsecond-half O\nfightback O\nto O\ndraw O\n4-4 O\nin O\ntheir O\nBundesliga B-MISC\nclash O\nwith O\nSchalke B-ORG\non O\nFriday O\n. O\n\nSchalke B-ORG\n, O\nwho O\nfinished O\nthird O\nlast O\nseason O\n, O\nraced O\nto O\na O\n3-1 O\nlead O\nat O\nhalftime O\n. O\n\nSt B-ORG\nPauli I-ORG\npulled O\na O\ngoal O\nback O\nthrough O\nAndre B-PER\nTrulsen I-PER\nbut O\nSchalke B-ORG\nstriker O\nMartin B-PER\nMax I-PER\nrestored O\nhis O\nteam O\n's O\ntwo-goal O\ncushion O\nshortly O\nafterwards O\n. O\n\nChristian B-PER\nSpringer I-PER\nput O\nSt B-ORG\nPauli I-ORG\nback O\nin O\ntouch O\nin O\nthe O\n64th O\nminute O\nand O\nthree O\nminutes O\nlater O\nthey O\nwere O\nlevel O\n, O\nthanks O\nto O\na O\npenalty O\nfrom O\nThomas B-PER\nSabotzik I-PER\n. O\n\nIn O\nthe O\nnight O\n's O\nonly O\nother O\nmatch O\n, O\nHamburg B-ORG\nbeat O\nHansa B-ORG\nRostock I-ORG\n1-0 O\n, O\nKarsten B-PER\nBaeron I-PER\nscoring O\nthe O\nwinner O\nafter O\nsome O\ndazzling O\nbuild-up O\nfrom O\nin-form O\nmidfielder O\nHarald B-PER\nSpoerl I-PER\n. O\n\nThe O\nwin O\nput O\nHamburg B-ORG\nin O\nsecond O\nplace O\nin O\nthe O\nGerman B-MISC\nfirst O\ndivision O\nafter O\nthree O\ngames O\n, O\nthough O\nthat O\nmay O\nchange O\nafter O\nthe O\nother O\nsides O\nplay O\non O\nSaturday O\n. O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nSALAH B-PER\nHISSOU I-PER\nBREAKS O\n10,000 O\nMETRES O\nWORLD O\nRECORD O\n. O\n\nBRUSSELS B-LOC\n1996-08-23 O\n\nMorocco B-LOC\n's O\nSalah B-PER\nHissou I-PER\nbroke O\nthe O\nmen O\n's O\n10,000 O\nmetres O\nworld O\nrecord O\non O\nFriday O\nwhen O\nhe O\nclocked O\n26 O\nminutes O\n38.08 O\nseconds O\nat O\nthe O\nBrussels B-LOC\ngrand O\nprix O\non O\nFriday O\n. O\n\nThe O\nprevious O\nmark O\nof O\n26:43.53 O\nwas O\nset O\nby O\nEthiopia B-LOC\n's O\nHaile B-PER\nGebreselassie I-PER\nin O\nthe O\nDutch B-MISC\ntown O\nof O\nHengelo B-LOC\nin O\nJune O\nlast O\nyear O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nSUMMARIES O\n. O\n\nBONN B-LOC\n1996-08-23 O\n\nSummaries O\nof O\nBundesliga B-MISC\nmatches O\non O\nFriday O\n: O\n\nHansa B-ORG\nRostock I-ORG\n0 O\nHamburg B-ORG\n1 O\n( O\nBaeron B-PER\n64th O\nmin O\n) O\n. O\n\nHalftime O\n0-0 O\n. O\n\nAttendance O\n18,500 O\n. O\n\nSt B-ORG\nPauli I-ORG\n4 O\n( O\nDriller B-PER\n15th O\n, O\nTrulsen B-PER\n54th O\n, O\nSpringer B-PER\n64th O\n, O\nSobotzik B-PER\n67th O\npenalty O\n) O\nSchalke B-ORG\n4 O\n( O\nMax B-PER\n11th O\n, O\nThon B-PER\n34th O\n, O\nWilmots B-PER\n38th O\n, O\nSpringer B-PER\n64th O\n) O\n. O\n\n1-3 O\n. O\n\n19,775 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nSUMMARY O\n. O\n\nPARIS B-LOC\n1996-08-23 O\n\nSummary O\nof O\na O\nFrench B-MISC\nfirst O\ndivision O\nmatch O\non O\nFriday O\n. O\n\nNancy B-ORG\n0 O\nParis B-ORG\nSt I-ORG\nGermain I-ORG\n0 O\n. O\n\nAttendance O\n: O\n15,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nRESULT O\n. O\n\nPARIS B-LOC\n1996-08-23 O\n\nResult O\nof O\na O\nFrench B-MISC\nfirst O\ndivision O\nmatch O\non O\nFriday O\n. O\n\nNancy B-ORG\n0 O\nParis B-ORG\nSt I-ORG\nGermain I-ORG\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n. O\n\nBONN B-LOC\n1996-08-23 O\n\nResults O\nof O\nGerman B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatches O\non O\nFriday O\n: O\n\nSt B-ORG\nPauli I-ORG\n4 O\nSchalke B-ORG\n4 O\n\nHansa B-ORG\nRostock I-ORG\n0 O\nHamburg B-ORG\n1 O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nMASTERKOVA B-PER\nBREAKS O\nSECOND O\nWORLD O\nRECORD O\nIN O\n10 O\nDAYS O\n. O\n\nAdrian B-PER\nWarner I-PER\n\nBRUSSELS B-LOC\n1996-08-23 O\n\nRussia B-LOC\n's O\ndouble O\nOlympic B-MISC\nchampion O\nSvetlana B-PER\nMasterkova I-PER\nsmashed O\nher O\nsecond O\nworld O\nrecord O\nin O\njust O\n10 O\ndays O\non O\nFriday O\nwhen O\nshe O\nbettered O\nthe O\nmark O\nfor O\nthe O\nwomen O\n's O\n1,000 O\nmetres O\n. O\n\nAfter O\nbreaking O\nthe O\nworld O\nrecord O\nfor O\nthe O\nwomen O\n's O\nmile O\nin O\nZurich B-LOC\nlast O\nWednesday O\n, O\nthe O\nOlympic B-MISC\n800 O\nand O\n1,500 O\nmetres O\nchampion O\nclocked O\ntwo O\nminutes O\n28.98 O\nseconds O\nover O\n1,000 O\nat O\nthe O\nBrussels B-LOC\ngrand O\nprix O\nmeeting O\n. O\n\nThe O\nRussian B-MISC\nate O\nup O\nthe O\nground O\nin O\na O\nswift O\nlast O\nlap O\nto O\nshave O\n0.36 O\nseconds O\noff O\nthe O\nprevious O\nbest O\nof O\n2:29.34 O\nset O\nby O\nMozambique B-LOC\n's O\nMaria B-PER\nMutola I-PER\nin O\nthe O\nsame O\nstadium O\nin O\nAugust O\nlast O\nyear O\n. O\n\nFormer O\nworld O\n800 O\nchampion O\nMutola B-PER\npushed O\nMasterkova B-PER\nall O\nthe O\nway O\n, O\nfinishing O\nsecond O\nin O\n2:29.66 O\n. O\n\nBut O\nit O\nwas O\nthe O\nRussian B-MISC\nwho O\npicked O\nup O\nthe O\nbonus O\nof O\n$ O\n25,000 O\nfor O\nthe O\nhistoric O\nrun O\nin O\nfront O\nof O\na O\ncapacity O\n40,000 O\ncrowd O\n. O\n\nMasterkova B-PER\ndominated O\nthe O\nmiddle-distance O\nraces O\nat O\nthe O\nrecent O\nAtlanta B-MISC\nGames I-MISC\nfollowing O\nher O\nreturn O\nto O\ncompetition O\nthis O\nseason O\nafter O\na O\nthree-year O\nmaternity O\nbreak O\n. O\n\nIn O\nher O\nfirst O\nmile O\nrace O\nat O\nthe O\nrichest O\nmeeting O\nin O\nZurich B-LOC\nlast O\nWednesday O\n, O\nshe O\nslashed O\n3.05 O\nseconds O\noff O\nthe O\nprevious O\nrecord O\n. O\n\nThe O\nrecord O\nof O\nfour O\nminutes O\n, O\n12.56 O\nseconds O\nin O\nZurich B-LOC\nearned O\nMasterkova B-PER\na O\nbonus O\nof O\n$ O\n50,000 O\nplus O\none O\nkilo O\nof O\ngold O\n. O\n\nAfter O\nFriday O\n's O\nperformance O\nthe O\nRussian B-MISC\nwill O\nhave O\nearned O\nwell O\nover O\n$ O\n100,000 O\nin O\nless O\nthan O\na O\nfortnight O\n, O\ntaking O\nher O\nappearance O\nmoney O\ninto O\naccount O\n. O\n\nBrussels B-LOC\norganisers O\nhad O\nlaid O\na O\nnew O\ntrack O\nfor O\nthe O\nmeeting O\ncomparable O\nto O\nthe O\nsurface O\nat O\nthe O\nAtlanta B-MISC\nGames I-MISC\nbut O\nput O\ndown O\non O\na O\nsofter O\nsurface O\n. O\n\nMasterkova B-PER\nclearly O\nenjoyed O\nit O\n. O\n\nMutola B-PER\nlooked O\nthreatening O\nin O\nthe O\nfinal O\n200 O\nmetres O\nbut O\nthe O\nRussian B-MISC\nfound O\nan O\nextra O\ngear O\nto O\npower O\nhome O\nseveral O\nstrides O\nahead O\n, O\npointing O\nat O\nthe O\ntime O\non O\nthe O\nclock O\nwith O\ndelight O\nas O\nshe O\ncrossed O\nthe O\nline O\n. O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nWOMEN O\n'S O\n1,000 O\nMETRES O\nWORLD O\nRECORD O\nEVOLUTION O\n. O\n\nBRUSSELS B-LOC\n1996-08-23 O\n\nEvolution O\nof O\nthe O\nwomen O\n's O\n1,000 O\n\nmetres O\nworld O\nrecord O\n( O\ntabulated O\nunder O\ntime O\n, O\nname O\n/ O\nnationality O\n, O\n\nvenue O\n, O\ndate O\n) O\n: O\n\n2:30.67 O\nChristine B-PER\nWachtel I-PER\n( O\nGermany B-LOC\n) O\nBerlin B-LOC\n17.8.90 O\n\n2:29.34 O\nMaria B-PER\nMutola I-PER\n( O\nMozambique B-LOC\n) O\nBrussels B-LOC\n25.8.95 O\n\n2:28.98 O\nSvetlana B-PER\nMasterkova I-PER\n( O\nRussia B-LOC\n) O\nBrussels B-LOC\n23.8.96 O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nMASTERKOVA B-PER\nBREAKS O\nWOMEN O\n'S O\nWORLD O\n1,000 O\nRECORD O\n. O\n\nBRUSSELS B-LOC\n1996-08-23 O\n\nRussian B-MISC\nSvetlana B-PER\nMasterkova I-PER\nbroke O\nthe O\nwomen O\n's O\nworld O\n1,000 O\nmetres O\nrecord O\non O\nFriday O\nwhen O\nshe O\nclocked O\nan O\nunofficial O\ntwo O\nminutes O\n28.99 O\nseconds O\nat O\nthe O\nBrussels B-LOC\ngrand O\nprix O\n. O\n\nThe O\nprevious O\nmark O\nof O\n2:29.34 O\nwas O\nset O\nby O\nMozambique B-LOC\n's O\nMaria B-PER\nMutola I-PER\nhere O\non O\nAugust O\n25 O\nlast O\nyear O\n. O\n\nThe O\ntime O\nwas O\nofficially O\nadjusted O\nto O\n2:28.98 O\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nGERMAN B-MISC\nOPEN I-MISC\nSECOND O\nROUND O\nSCORES O\n. O\n\nSTUTTGART B-LOC\n, O\nGermany B-LOC\n1996-08-23 O\n\nLeading O\nsecond O\nround O\n\nscores O\nin O\nthe O\nGerman B-MISC\nOpen I-MISC\ngolf O\nchampionship O\non O\nFriday O\n( O\nBritain B-LOC\n\nunless O\nstated O\n) O\n: O\n\n128 O\nIan B-PER\nWoosnam I-PER\n64 O\n64 O\n\n129 O\nRobert B-PER\nKarlsson I-PER\n( O\nSweden B-LOC\n) O\n67 O\n62 O\n\n130 O\nFernando B-PER\nRoca I-PER\n( O\nSpain B-LOC\n) O\n66 O\n64 O\n, O\nIan B-PER\nPyman I-PER\n66 O\n64 O\n\n131 O\nCarl B-PER\nSuneson I-PER\n65 O\n66 O\n, O\nStephen B-PER\nField I-PER\n66 O\n65 O\n\n132 O\nMiguel B-PER\nAngel I-PER\nMartin I-PER\n( O\nSpain B-LOC\n) O\n66 O\n66 O\n, O\nRaymond B-PER\nRussell I-PER\n63 O\n69 O\n, O\n\nThomas B-PER\nGogele I-PER\n( O\nGermany B-LOC\n) O\n67 O\n65 O\n, O\nPaul B-PER\nBroadhurst I-PER\n62 O\n70 O\n, O\n\nDiego B-PER\nBorrego I-PER\n( O\nSpain B-LOC\n) O\n69 O\n63 O\n\n133 O\nRicky B-PER\nWillison I-PER\n69 O\n64 O\n, O\nStephen B-PER\nAmes I-PER\n( O\nTrinidad B-LOC\nand I-LOC\nTobago I-LOC\n) O\n\n68 O\n65 O\n, O\nEamonn B-PER\nDarcy I-PER\n( O\nIreland B-LOC\n) O\n65 O\n68 O\n\n134 O\nRobert B-PER\nColes I-PER\n68 O\n66 O\n, O\nDavid B-PER\nWilliams I-PER\n67 O\n67 O\n, O\nThomas B-PER\nBjorn I-PER\n\n( O\nDenmark B-LOC\n) O\n66 O\n68 O\n, O\nPedro B-PER\nLinhart I-PER\n( O\nSpain B-LOC\n) O\n67 O\n67 O\n, O\nMichael B-PER\n\nJonzon B-PER\n( O\nSweden B-LOC\n) O\n67 O\n67 O\n, O\nRoger B-PER\nChapman I-PER\n72 O\n62 O\n, O\nJonathan B-PER\nLomas I-PER\n\n67 O\n67 O\n, O\nFrancisco B-PER\nCea I-PER\n( O\nSpain B-LOC\n) O\n68 O\n66 O\n\n135 O\nTerry B-PER\nPrice I-PER\n( O\nAustralia B-LOC\n) O\n67 O\n68 O\n, O\nPaul B-PER\nEales I-PER\n67 O\n68 O\n, O\nWayne B-PER\n\nRiley B-PER\n( O\nAustralia B-LOC\n) O\n64 O\n71 O\n, O\nCarl B-PER\nMason I-PER\n69 O\n66 O\n, O\nBarry B-PER\nLane I-PER\n\n68 O\n67 O\n, O\nBernhard B-PER\nLanger I-PER\n( O\nGermany B-LOC\n) O\n64 O\n71 O\n, O\nGary B-PER\nOrr I-PER\n67 O\n68 O\n, O\n\nMats B-PER\nLanner I-PER\n( O\nSweden B-LOC\n) O\n64 O\n71 O\n, O\nJeff B-PER\nHawksworth I-PER\n67 O\n68 O\n, O\nDes B-PER\n\nSmyth B-PER\n( O\nIreland B-LOC\n) O\n66 O\n69 O\n, O\nDavid B-PER\nCarter I-PER\n66 O\n69 O\n, O\nSteve B-PER\nWebster I-PER\n\n69 O\n66 O\n, O\nJose B-PER\nMaria I-PER\nCanizares I-PER\n( O\nSpain B-LOC\n) O\n67 O\n68 O\n, O\nPaul B-PER\nLawrie I-PER\n\n66 O\n69 O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nMITCHELL B-PER\nUPSTAGES O\nTRIO O\nOF O\nOLYMPIC B-MISC\nSPRINT O\nCHAMPIONS O\n. O\n\nAdrian B-PER\nWarner I-PER\n\nBRUSSELS B-LOC\n1996-08-23 O\n\nAmerican B-MISC\nDennis B-PER\nMitchell I-PER\nupstaged O\na O\ntrio O\nof O\npast O\nand O\npresent O\nOlympic B-MISC\n100 O\nmetres O\nchampions O\non O\nFriday O\nwith O\na O\nstorming O\nvictory O\nat O\nthe O\nBrussels B-LOC\ngrand O\nprix O\n. O\n\nSporting B-ORG\nhis O\ncustomary O\nbright O\ngreen O\noutfit O\n, O\nthe O\nU.S. B-LOC\nchampion O\nclocked O\n10.03 O\nseconds O\ndespite O\ndamp O\nconditions O\nto O\ntake O\nthe O\nscalp O\nof O\nCanada B-LOC\n's O\nreigning O\nOlympic B-MISC\nchampion O\nDonovan B-PER\nBailey I-PER\n, O\n1992 O\nchampion O\nLinford B-PER\nChristie I-PER\nof O\nBritain B-LOC\nand O\nAmerican B-MISC\n1984 O\nand O\n1988 O\nchampion O\nCarl B-PER\nLewis I-PER\n. O\n\nMitchell B-PER\nalso O\nbeat O\nworld O\nand O\nOlympic B-MISC\nchampion O\nBailey B-PER\nat O\nthe O\nmost O\nlucrative O\nmeeting O\nin O\nthe O\nsport O\nin O\nZurich B-LOC\nlast O\nweek O\n. O\n\nThe O\nAmerican B-MISC\n, O\nwho O\nfinished O\nfourth O\nat O\nthe O\nAtlanta B-MISC\nGames I-MISC\n, O\nwas O\nfast O\nout O\nof O\nhis O\nblocks O\nand O\nheld O\noff O\nBailey B-PER\n's O\nlate O\nburst O\nin O\nthe O\nfinal O\n20 O\nmetres O\nbefore O\nheading O\noff O\nfor O\na O\nlap O\nof O\ncelebration O\n. O\n\nThe O\nCanadian B-MISC\nwas O\nsecond O\nin O\n10.09 O\nwith O\nLewis B-PER\nthird O\nin O\n10.10 O\n, O\nahead O\nof O\nAtlanta B-LOC\nbronze O\nmedallist O\nAto B-PER\nBoldon I-PER\nwho O\nclocked O\n10.12 O\nin O\nfourth O\n. O\n\nChristie B-PER\n, O\ncompeting O\nin O\nwhat O\nis O\nexpected O\nto O\nbe O\nhis O\nlast O\nmajor O\ninternational O\nmeeting O\n, O\nfinished O\nfifth O\nin O\n10.14 O\n. O\n\nLewis B-PER\n, O\nmaking O\na O\nrare O\nappearance O\nin O\nEurope B-LOC\nin O\na O\nsprint O\nrace O\n, O\nleft O\nthe O\ntrack O\nwith O\na O\nslight O\nlimp O\n. O\n\nAmerican B-MISC\nOlympic I-MISC\nhigh O\nhurdles O\nchampion O\nAllen B-PER\nJohnson I-PER\ndefied O\nthe O\nwet O\nconditions O\nto O\nproduce O\na O\nbrilliant O\n12.92 O\nseconds O\nin O\nthe O\n110 O\nmetres O\nrace O\n, O\njust O\n0.01 O\noutside O\nthe O\nworld O\nrecord O\nheld O\nby O\nBritain B-LOC\n's O\nColin B-PER\nJackson I-PER\n. O\n\nJohnson B-PER\nran O\nthe O\nsame O\ntime O\nat O\nthe O\nU.S. B-LOC\nOlympic B-MISC\ntrials O\nin O\nAtlanta B-LOC\nin O\nJune O\nto O\nbecome O\nthe O\nsecond O\nequal O\nfastest O\nhurdler O\nof O\nall O\ntime O\nwith O\nAmerican B-MISC\nRoger B-PER\nKingdom I-PER\n. O\n\nHe O\nseemed O\nto O\nrelish O\nthe O\nnew O\ntrack O\nat O\nthe O\nBrussels B-LOC\nmeeting O\n, O\ndominating O\nthe O\nrace O\nfrom O\nstart O\nto O\nfinish O\nwith O\na O\nslight O\nwind O\nat O\nhis O\nback O\n. O\n\nJackson B-PER\n, O\nthe O\nonly O\nman O\nto O\nhave O\nrun O\nfaster O\n, O\ncould O\nnot O\nlive O\nwith O\nhis O\nspeed O\n, O\ntaking O\nsecond O\nin O\n13.24 O\nseconds O\n. O\n\nThe O\nrain O\nwas O\npelting O\ndown O\nwhen O\nthe O\nwomen O\n's O\nhigh O\nhurdlers O\nstepped O\nup O\nfor O\ntheir O\n100 O\nmetres O\nrace O\n. O\n\nBut O\nSweden B-LOC\n's O\nOlympic B-MISC\nhigh O\nhurdles O\nchampion O\nLudmila B-PER\nEngquist I-PER\n, O\nwho O\ncrashed O\nout O\nof O\nlast O\nweek O\n's O\nmeeting O\nin O\nZurich B-LOC\nafter O\nhitting O\na O\nhurdle O\n, O\nalso O\nkept O\nher O\nfooting O\nperfectly O\nto O\nwin O\nin O\na O\nfast O\n12.60 O\nseconds O\n. O\n\nOlympic B-MISC\nsilver O\nmedallist O\nBrigita B-PER\nBukovec I-PER\nof O\nSlovenia B-LOC\ncould O\nfinish O\nonly O\nfifth O\nin O\nthe O\nrace O\nin O\n12.95 O\n. O\n\nJamaican B-MISC\nCommonwealth B-ORG\nchampion O\nMichelle B-PER\nFreeman I-PER\ntook O\nsecond O\nin O\n12.77 O\nahead O\nof O\nCuban B-MISC\nAliuska B-PER\nLopez I-PER\n. O\n\nThe O\nZurich B-LOC\nfall O\ncost O\nEngquist B-PER\na O\nshot O\nat O\na O\njackpot O\nof O\n20 O\none-kg O\ngold O\nbars O\nwhich O\ncan O\nbe O\nwon O\nby O\nathletes O\nwho O\nclinch O\ntheir O\nevents O\nat O\nall O\nof O\nthe O\nGolden B-MISC\nFour I-MISC\nseries O\nin O\nOslo B-LOC\n, O\nZurich B-LOC\n, O\nBrussels B-LOC\nand O\nBerlin B-LOC\n. O\n\nSeven O\nathletes O\nwent O\ninto O\nFriday O\n's O\npenultimate O\nmeeting O\nof O\nthe O\nseries O\nwith O\na O\nchance O\nof O\nwinning O\nthe O\nprize O\nand O\nAmerican B-MISC\nmen O\n's O\n400 O\nmetres O\nhurdles O\nchampion O\nDerrick B-PER\nAdkins I-PER\nkept O\nhis O\nhopes O\nalive O\nin O\nthe O\ncompetition O\nby O\nwinning O\nhis O\nevent O\nin O\n47.93 O\n. O\n\nAmerican B-MISC\nOlympic I-MISC\nchampion O\nGail B-PER\nDevers I-PER\nclocked O\na O\nswift O\n10.84 O\nseconds O\non O\nher O\nway O\nto O\nvictory O\nin O\nthe O\nwomen O\n's O\n100 O\nmetres O\n, O\nthe O\nsecond O\nfastest O\ntime O\nof O\nthe O\nseason O\nand O\n0.10 O\nseconds O\nfaster O\nthan O\nher O\nwinning O\ntime O\nin O\nAtlanta B-LOC\n. O\n\nJamaican B-MISC\nveteran O\nMerlene B-PER\nOttey I-PER\n, O\nwho O\nbeat O\nDevers B-PER\nin O\nZurich B-LOC\nafter O\njust O\nmissing O\nout O\non O\nthe O\ngold O\nmedal O\nin O\nAtlanta B-LOC\nafter O\na O\nphoto O\nfinish O\n, O\nhad O\nto O\nsettle O\nfor O\nthird O\nplace O\nin O\n11.04 O\n. O\n\nAmerican B-MISC\nworld O\nchampion O\nGwen B-PER\nTorrence I-PER\n, O\nthe O\nbronze O\nmedallist O\nin O\nAtlanta B-LOC\n, O\nwas O\nsecond O\nin O\n11.00 O\n. O\n\nIt O\nwas O\na O\ncostly O\ndefeat O\nfor O\nOttey B-PER\nsince O\nit O\nthrew O\nher O\nout O\nof O\nthe O\nrace O\nfor O\nthe O\nGolden B-MISC\nFour I-MISC\njackpot O\n. O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nBRUSSELS B-MISC\nGRAND I-MISC\nPRIX I-MISC\nRESULTS O\n. O\n\nBRUSSELS B-LOC\n1996-08-23 O\n\nLeading O\nresults O\nin O\nthe O\nBrussels B-MISC\n\nGrand B-MISC\nPrix I-MISC\nathletics O\nmeeting O\non O\nFriday O\n: O\n\nWomen O\n's O\ndiscus O\n\n1. O\nIlke B-PER\nWyludda I-PER\n( O\nGermany B-LOC\n) O\n66.60 O\nmetres O\n\n2. O\nEllina B-PER\nZvereva I-PER\n( O\nBelarus B-LOC\n) O\n65.66 O\n\n3. O\nFranka B-PER\nDietzsch I-PER\n( O\nGermany B-LOC\n) O\n61.74 O\n\n4. O\nNatalya B-PER\nSadova I-PER\n( O\nRussia B-LOC\n) O\n61.64 O\n\n5. O\nMette B-PER\nBergmann I-PER\n( O\nNorway B-LOC\n) O\n61.44 O\n\n6. O\nNicoleta B-PER\nGrasu I-PER\n( O\nRomania B-LOC\n) O\n61.36 O\n\n7. O\nOlga B-PER\nChernyavskaya I-PER\n( O\nRussia B-LOC\n) O\n60.46 O\n\n8. O\nIrina B-PER\nYatchenko I-PER\n( O\nBelarus B-LOC\n) O\n58.92 O\n\nWomen O\n's O\n100 O\nmetres O\nhurdles O\n\n1. O\nLudmila B-PER\nEngquist I-PER\n( O\nSweden B-LOC\n) O\n12.60 O\nseconds O\n\n2. O\nMichelle B-PER\nFreeman I-PER\n( O\nJamaica B-LOC\n) O\n12.77 O\n\n3. O\nAliuska B-PER\nLopez I-PER\n( O\nCuba B-LOC\n) O\n12.85 O\n\n4. O\nDionne B-PER\nRose I-PER\n( O\nJamaica B-LOC\n) O\n12.88 O\n\n5. O\nBrigita B-PER\nBukovec I-PER\n( O\nSlovakia B-LOC\n) O\n12.95 O\n\n6. O\nYulia B-PER\nGraudin I-PER\n( O\nRussia B-LOC\n) O\n12.96 O\n\n7. O\nJulie B-PER\nBaumann I-PER\n( O\nSwitzerland B-LOC\n) O\n13.36 O\n\n8. O\nPatricia B-PER\nGirard-Leno I-PER\n( O\nFrance B-LOC\n) O\n13.36 O\n\n9. O\nDawn B-PER\nBowles I-PER\n( O\nU.S. B-LOC\n) O\n13.53 O\n\nMen O\n's O\n110 O\nmetres O\nhurdles O\n\n1. O\nAllen B-PER\nJohnson I-PER\n( O\nU.S. B-LOC\n) O\n12.92 O\nseconds O\n\n2. O\nColin B-PER\nJackson I-PER\n( O\nBritain B-LOC\n) O\n13.24 O\n\n3. O\nEmilio B-PER\nValle I-PER\n( O\nCuba B-LOC\n) O\n13.33 O\n\n4. O\nSven B-PER\nPieters I-PER\n( O\nBelgium B-LOC\n) O\n13.37 O\n\n5. O\nSteve B-PER\nBrown I-PER\n( O\nU.S. B-LOC\n) O\n13.38 O\n\n6. O\nFrank B-PER\nAsselman I-PER\n( O\nBelgium B-LOC\n) O\n13.64 O\n\n7. O\nHubert B-PER\nGrossard I-PER\n( O\nBelgium B-LOC\n) O\n13.65 O\n\n8. O\nJonathan B-PER\nN'Senga I-PER\n( O\nBelgium B-LOC\n) O\n13.66 O\n\n9. O\nJohan B-PER\nLisabeth I-PER\n( O\nBelgium B-LOC\n) O\n13.75 O\n\nWomen O\n's O\n5,000 O\nmetres O\n\n1. O\nRoberta B-PER\nBrunet I-PER\n( O\nItaly B-LOC\n) O\n14 O\nminutes O\n48.96 O\nseconds O\n\n2. O\nFernanda B-PER\nRibeiro I-PER\n( O\nPortugal B-LOC\n) O\n14:49.81 O\n\n3. O\nSally B-PER\nBarsosio I-PER\n( O\nKenya B-LOC\n) O\n14:58.29 O\n\n4. O\nPaula B-PER\nRadcliffe I-PER\n( O\nBritain B-LOC\n) O\n14:59.70 O\n\n5. O\nJulia B-PER\nVaquero I-PER\n( O\nSpain B-LOC\n) O\n15:04.94 O\n\n6. O\nCatherine B-PER\nMcKiernan I-PER\n( O\nIreland B-LOC\n) O\n15:07.57 O\n\n7. O\nAnnette B-PER\nPeters I-PER\n( O\nU.S. B-LOC\n) O\n15:07.85 O\n\n8. O\nPauline B-PER\nKonga I-PER\n( O\nKenya B-LOC\n) O\n15:11.40 O\n\nMen O\n's O\n100 O\nmetres O\n\n1. O\nDennis B-PER\nMitchell I-PER\n( O\nU.S. B-LOC\n) O\n10.03 O\nseconds O\n\n2. O\nDonovan B-PER\nBailey I-PER\n( O\nCanada B-LOC\n) O\n10.09 O\n\n3. O\nCarl B-PER\nLewis I-PER\n( O\nU.S. B-LOC\n) O\n10.10 O\n\n4. O\nAto B-PER\nBoldon I-PER\n( O\nTrinidad B-LOC\n) O\n10.12 O\n\n5. O\nLinford B-PER\nChristie I-PER\n( O\nBritain B-LOC\n) O\n10.14 O\n\n6. O\nDavidson B-PER\nEzinwa I-PER\n( O\nNigeria B-LOC\n) O\n10.15 O\n\n7. O\nJon B-PER\nDrummond I-PER\n( O\nU.S. B-LOC\n) O\n10.16 O\n\n8. O\nBruny B-PER\nSurin I-PER\n( O\nCanada B-LOC\n) O\n10.30 O\n\nMen O\n's O\n400 O\nmetres O\nhurdles O\n\n1. O\nDerrick B-PER\nAdkins I-PER\n( O\nU.S. B-LOC\n) O\n47.93 O\nseconds O\n\n2. O\nSamuel B-PER\nMatete I-PER\n( O\nZambia B-LOC\n) O\n47.99 O\n\n3. O\nRohan B-PER\nRobinson I-PER\n( O\nAustralia B-LOC\n) O\n48.86 O\n\n4. O\nTorrance B-PER\nZellner I-PER\n( O\nU.S. B-LOC\n) O\n49.06 O\n\n5. O\nJean-Paul B-PER\nBruwier I-PER\n( O\nBelgium B-LOC\n) O\n49.24 O\n\n6. O\nDusan B-PER\nKovacs I-PER\n( O\nHungary B-LOC\n) O\n49.31 O\n\n7. O\nCalvin B-PER\nDavis I-PER\n( O\nU.S. B-LOC\n) O\n49.49 O\n\n8. O\nLaurent B-PER\nOttoz I-PER\n( O\nItaly B-LOC\n) O\n49.61 O\n\n9. O\nMarc B-PER\nDollendorf I-PER\n( O\nBelgium B-LOC\n) O\n50.36 O\n\nWomen O\n's O\n100 O\nmetres O\n\n1. O\nGail B-PER\nDevers I-PER\n( O\nU.S. B-LOC\n) O\n10.84 O\nseconds O\n\n2. O\nGwen B-PER\nTorrence I-PER\n( O\nU.S. B-LOC\n) O\n11.00 O\n\n3. O\nMerlene B-PER\nOttey I-PER\n( O\nJamaica B-LOC\n) O\n11.04 O\n\n4. O\nMary B-PER\nOnyali I-PER\n( O\nNigeria B-LOC\n) O\n11.09 O\n\n5. O\nChryste B-PER\nGaines I-PER\n( O\nU.S. B-LOC\n) O\n11.18 O\n\n6. O\nZhanna B-PER\nPintusevich I-PER\n( O\nUkraine B-LOC\n) O\n11.27 O\n\n7. O\nIrina B-PER\nPrivalova I-PER\n( O\nRussia B-LOC\n) O\n11.28 O\n\n8. O\nNatalia B-PER\nVoronova I-PER\n( O\nRussia B-LOC\n) O\n11.28 O\n\n9. O\nJuliet B-PER\nCuthbert I-PER\n( O\nJamaica B-LOC\n) O\n11.31 O\n\nWomen O\n's O\n1,500 O\nmetres O\n\n1. O\nRegina B-PER\nJacobs I-PER\n( O\nU.S. B-LOC\n) O\n4 O\nminutes O\n01.77 O\nseconds O\n\n2. O\nPatricia B-PER\nDjate I-PER\n( O\nFrance B-LOC\n) O\n4:02.26 O\n\n3. O\nCarla B-PER\nSacramento I-PER\n( O\nPortugal B-LOC\n) O\n4:02.67 O\n\n4. O\nYekaterina B-PER\nPodkopayeva I-PER\n( O\nRussia B-LOC\n) O\n4:04.78 O\n\n5. O\nMargret B-PER\nCrowley I-PER\n( O\nAustralia B-LOC\n) O\n4:05.00 O\n\n6. O\nLeah B-PER\nPells I-PER\n( O\nCanada B-LOC\n) O\n4:05.64 O\n\n7. O\nSarah B-PER\nThorsett I-PER\n( O\nU.S. B-LOC\n) O\n4:06.80 O\n\n8. O\nSinead B-PER\nDelahunty I-PER\n( O\nIreland B-LOC\n) O\n4:07.27 O\n\n3,000 O\nmetres O\nsteeplechase O\n\n1. O\nJoseph B-PER\nKeter I-PER\n( O\nKenya B-LOC\n) O\n8 O\nminutes O\n10.02 O\nseconds O\n\n2. O\nPatrick B-PER\nSang I-PER\n( O\nKenya B-LOC\n) O\n8:12.04 O\n\n3. O\nMoses B-PER\nKiptanui I-PER\n( O\nKenya B-LOC\n) O\n8:12.65 O\n\n4. O\nGideon B-PER\nChirchir I-PER\n( O\nKenya B-LOC\n) O\n8:15.69 O\n\n5. O\nRichard B-PER\nKosgei I-PER\n( O\nKenya B-LOC\n) O\n8:16.80 O\n\n6. O\nLarbi B-PER\nEl I-PER\nKhattabi I-PER\n( O\nMorocco B-LOC\n) O\n8:17.29 O\n\n7. O\nEliud B-PER\nBarngetuny I-PER\n( O\nKenya B-LOC\n) O\n8:17.66 O\n\n8. O\nBernard B-PER\nBarmasai I-PER\n( O\nKenya B-LOC\n) O\n8:17.94 O\n\nMen O\n's O\n400 O\nmetres O\n\n1. O\nMichael B-PER\nJohnson I-PER\n( O\nU.S. B-LOC\n) O\n44.29 O\nseconds O\n\n2. O\nDerek B-PER\nMills I-PER\n( O\nU.S. B-LOC\n) O\n44.78 O\n\n3. O\nAnthuan B-PER\nMaybank I-PER\n( O\nU.S. B-LOC\n) O\n44.92 O\n\n4. O\nDavis B-PER\nKamoga I-PER\n( O\nUganda B-LOC\n) O\n44.96 O\n\n5. O\nJamie B-PER\nBaulch I-PER\n( O\nBritain B-LOC\n) O\n45.08 O\n\n6. O\nSunday B-PER\nBada I-PER\n( O\nNigeria B-LOC\n) O\n45.21 O\n\n7. O\nSamson B-PER\nKitur I-PER\n( O\nKenya B-LOC\n) O\n45.34 O\n\n8. O\nMark B-PER\nRichardson I-PER\n( O\nBritain B-LOC\n) O\n45.67 O\n\n9. O\nJason B-PER\nRouser I-PER\n( O\nU.S. B-LOC\n) O\n46.11 O\n\nMen O\n's O\n200 O\nmetres O\n\n1. O\nFrankie B-PER\nFredericks I-PER\n( O\nNamibia B-LOC\n) O\n19.92 O\nseconds O\n\n2. O\nAto B-PER\nBoldon I-PER\n( O\nTrinidad B-LOC\n) O\n19.99 O\n\n3. O\nJeff B-PER\nWilliams I-PER\n( O\nU.S. B-LOC\n) O\n20.21 O\n\n4. O\nJon B-PER\nDrummond I-PER\n( O\nU.S. B-LOC\n) O\n20.42 O\n\n5. O\nPatrick B-PER\nStevens I-PER\n( O\nBelgium B-LOC\n) O\n20.42 O\n\n6. O\nMichael B-PER\nMarsh I-PER\n( O\nU.S. B-LOC\n) O\n20.43 O\n\n7. O\nIvan B-PER\nGarcia I-PER\n( O\nCuba B-LOC\n) O\n20.45 O\n\n8. O\nEric B-PER\nWymeersch I-PER\n( O\nBelgium B-LOC\n) O\n20.84 O\n\n9. O\nLamont B-PER\nSmith I-PER\n( O\nU.S. B-LOC\n) O\n21.08 O\n\nWomen O\n's O\n1,000 O\nmetres O\n\n1. O\nSvetlana B-PER\nMasterkova I-PER\n( O\nRussia B-LOC\n) O\n2 O\nminutes O\n28.98 O\nseconds O\n\n( O\nworld O\nrecord O\n) O\n\n2. O\nMaria B-PER\nMutola I-PER\n( O\nMozambique B-LOC\n) O\n2:29.66 O\n\n3. O\nMalgorzata B-PER\nRydz I-PER\n( O\nPoland B-LOC\n) O\n2:39.00 O\n\n4. O\nAnja B-PER\nSmolders I-PER\n( O\nBelgium B-LOC\n) O\n2:43.06 O\n\n5. O\nVeerle B-PER\nDe I-PER\nJaeghere I-PER\n( O\nBelgium B-LOC\n) O\n2:43.18 O\n\n6. O\nEleonora B-PER\nBerlanda I-PER\n( O\nItaly B-LOC\n) O\n2:43.44 O\n\n7. O\nAnneke B-PER\nMatthijs I-PER\n( O\nBelgium B-LOC\n) O\n2:43.82 O\n\n8. O\nJacqueline B-PER\nMartin I-PER\n( O\nSpain B-LOC\n) O\n2:44.22 O\n\nWomen O\n's O\n200 O\nmetres O\n\n1. O\nMary B-PER\nOnyali I-PER\n( O\nNigeria B-LOC\n) O\n22.42 O\nseconds O\n\n2. O\nInger B-PER\nMiller I-PER\n( O\nU.S. B-LOC\n) O\n22.66 O\n\n3. O\nIrina B-PER\nPrivalova I-PER\n( O\nRussia B-LOC\n) O\n22.68 O\n\n4. O\nNatalia B-PER\nVoronova I-PER\n( O\nRussia B-LOC\n) O\n22.73 O\n\n5. O\nMarina B-PER\nTrandenkova I-PER\n( O\nRussia B-LOC\n) O\n22.84 O\n\n6. O\nChandra B-PER\nSturrup I-PER\n( O\nBahamas B-LOC\n) O\n22.85 O\n\n7. O\nZundra B-PER\nFeagin I-PER\n( O\nU.S. B-LOC\n) O\n23.18 O\n\n8. O\nGalina B-PER\nMalchugina I-PER\n( O\nRussia B-LOC\n) O\n23.25 O\n\nWomen O\n's O\n400 O\nmetres O\n\n1. O\nCathy B-PER\nFreeman I-PER\n( O\nAustralia B-LOC\n) O\n49.48 O\nseconds O\n\n2. O\nMarie-Jose B-PER\nPerec I-PER\n( O\nFrance B-LOC\n) O\n49.72 O\n\n3. O\nFalilat B-PER\nOgunkoya I-PER\n( O\nNigeria B-LOC\n) O\n49.97 O\n\n4. O\nPauline B-PER\nDavis I-PER\n( O\nBahamas B-LOC\n) O\n50.14 O\n\n5. O\nFatima B-PER\nYussuf I-PER\n( O\nNigeria B-LOC\n) O\n50.14 O\n\n6. O\nMaicel B-PER\nMalone I-PER\n( O\nU.S. B-LOC\n) O\n50.51 O\n\n7. O\nHana B-PER\nBenesova I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n51.71 O\n\n8. O\nAnn B-PER\nMercken I-PER\n( O\nBelgium B-LOC\n) O\n53.55 O\n\nMen O\n's O\n3,000 O\nmetres O\n\n1. O\nDaniel B-PER\nKomen I-PER\n( O\nKenya B-LOC\n) O\n7 O\nminutes O\n25.87 O\nseconds O\n\n2. O\nKhalid B-PER\nBoulami I-PER\n( O\nMorocco B-LOC\n) O\n7:31.65 O\n\n3. O\nBob B-PER\nKennedy I-PER\n( O\nU.S. B-LOC\n) O\n7:31.69 O\n\n4. O\nEl B-PER\nHassane I-PER\nLahssini I-PER\n( O\nMorocco B-LOC\n) O\n7:32.44 O\n\n5. O\nThomas B-PER\nNyariki I-PER\n( O\nKenya B-LOC\n) O\n7:35.56 O\n\n6. O\nNoureddine B-PER\nMorceli I-PER\n( O\nAlgeria B-LOC\n) O\n7:36.81 O\n\n7. O\nFita B-PER\nBayesa I-PER\n( O\nEthiopia B-LOC\n) O\n7:38.09 O\n\n8. O\nMartin B-PER\nKeino I-PER\n( O\nKenya B-LOC\n) O\n7:38.88 O\n\nMen O\n's O\ndiscus O\n\n1. O\nLars B-PER\nRiedel I-PER\n( O\nGermany B-LOC\n) O\n66.74 O\nmetres O\n\n2. O\nAnthony B-PER\nWashington I-PER\n( O\nU.S. B-LOC\n) O\n66.72 O\n\n3. O\nVladimir B-PER\nDubrovshchik I-PER\n( O\nBelarus B-LOC\n) O\n64.02 O\n\n4. O\nVirgilius B-PER\nAlekna I-PER\n( O\nLithuania B-LOC\n) O\n63.62 O\n\n5. O\nJuergen B-PER\nSchult I-PER\n( O\nGermany B-LOC\n) O\n63.48 O\n\n6. O\nVassiliy B-PER\nKaptyukh I-PER\n( O\nBelarus B-LOC\n) O\n61.80 O\n\n7. O\nVaclavas B-PER\nKidikas I-PER\n( O\nLithuania B-LOC\n) O\n60.92 O\n\n8. O\nMichael B-PER\nMollenbeck I-PER\n( O\nGermany B-LOC\n) O\n59.24 O\n\nMen O\n's O\ntriple O\njump O\n\n1. O\nJonathan B-PER\nEdwards I-PER\n( O\nBritain B-LOC\n) O\n17.50 O\nmetres O\n\n2. O\nYoelvis B-PER\nQuesada I-PER\n( O\nCuba B-LOC\n) O\n17.29 O\n\n3. O\nBrian B-PER\nWellman I-PER\n( O\nBermuda B-LOC\n) O\n17.05 O\n\n4. O\nKenny B-PER\nHarrison I-PER\n( O\nU.S. B-LOC\n) O\n16.97 O\n\n5. O\nGennadi B-PER\nMarkov I-PER\n( O\nRussia B-LOC\n) O\n16.66 O\n\n6. O\nFrancis B-PER\nAgyepong I-PER\n( O\nBritain B-LOC\n) O\n16.63 O\n\n7. O\nRogel B-PER\nNachum I-PER\n( O\nIsrael B-LOC\n) O\n16.36 O\n\n8. O\nSigurd B-PER\nNjerve I-PER\n( O\nNorway B-LOC\n) O\n16.35 O\n\nMen O\n's O\n1,500 O\nmetres O\n\n1. O\nHicham B-PER\nEl I-PER\nGuerrouj I-PER\n( O\nMorocco B-LOC\n) O\nthree O\nminutes O\n29.05 O\nseconds O\n\n2. O\nIsaac B-PER\nViciosa I-PER\n( O\nSpain B-LOC\n) O\n3:33.00 O\n\n3. O\nWilliam B-PER\nTanui I-PER\n( O\nKenya B-LOC\n) O\n3:33.36 O\n\n4. O\nElijah B-PER\nMaru I-PER\n( O\nKenya B-LOC\n) O\n3:33.64 O\n\n5. O\nMarcus B-PER\nO'Sullivan I-PER\n( O\nIreland B-LOC\n) O\n3:33.77 O\n\n6. O\nJohn B-PER\nMayock I-PER\n( O\nBritain B-LOC\n) O\n3:33.94 O\n\n7. O\nLaban B-PER\nRotich I-PER\n( O\nKenya B-LOC\n) O\n3:34.12 O\n\n8. O\nChristophe B-PER\nImpens I-PER\n( O\nBelgium B-LOC\n) O\n3:34.13 O\n\nWomen O\n's O\nhigh O\njump O\n\n1. O\nStefka B-PER\nKostadinova I-PER\n( O\nBulgaria B-LOC\n) O\n2.03 O\nmetres O\n\n2. O\nInga B-PER\nBabakova I-PER\n( O\nUkraine B-LOC\n) O\n2.03 O\n\n3. O\nAlina B-PER\nAstafei I-PER\n( O\nGermany B-LOC\n) O\n1.97 O\n\n4. O\nTatyana B-PER\nMotkova I-PER\n( O\nRussia B-LOC\n) O\n1.94 O\n\n5. O\nSvetlana B-PER\nZalevskaya I-PER\n( O\nKazakhstan B-LOC\n) O\n1.91 O\n\n6. O\nYelena B-PER\nGulyayeva I-PER\n( O\nRussia B-LOC\n) O\n1.88 O\n\n7. O\nHanna B-PER\nHaugland I-PER\n( O\nNorway B-LOC\n) O\n1.88 O\n\n8 O\nequal O\n. O\n\nOlga B-PER\nBoshova I-PER\n( O\nMoldova B-LOC\n) O\n1.85 O\n\n8 O\nequal O\n. O\n\nNele B-PER\nZilinskiene I-PER\n( O\nLithuania B-LOC\n) O\n1.85 O\n\nMen O\n's O\n10,000 O\nmetres O\n\n1. O\nSalah B-PER\nHissou I-PER\n( O\nMorocco B-LOC\n) O\n26 O\nminutes O\n38.08 O\nseconds O\n( O\nworld O\n\nrecord O\n) O\n\n2. O\nPaul B-PER\nTergat I-PER\n( O\nKenya B-LOC\n) O\n26:54.41 O\n\n3. O\nPaul B-PER\nKoech I-PER\n( O\nKenya B-LOC\n) O\n26:56.78 O\n\n4. O\nWilliam B-PER\nKiptum I-PER\n( O\nKenya B-LOC\n) O\n27:18.84 O\n\n5. O\nAloys B-PER\nNizigama I-PER\n( O\nBurundi B-LOC\n) O\n27:25.13 O\n\n6. O\nMathias B-PER\nNtawulikura I-PER\n( O\nRwanda B-LOC\n) O\n27:25.48 O\n\n7. O\nAbel B-PER\nAnton I-PER\n( O\nSpain B-LOC\n) O\n28:18.44 O\n\n8. O\nKamiel B-PER\nMaase I-PER\n( O\nNetherlands B-LOC\n) O\n28.29.42 O\n\n9. O\nWorku B-PER\nBekila I-PER\n( O\nEthiopia B-LOC\n) O\n28.42.23 O\n\n10. O\nRobert B-PER\nStefko I-PER\n( O\nSlovakia B-LOC\n) O\n28:42.26 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nJORGE B-PER\nCALLS O\nUP O\nSIX O\nPORTO B-ORG\nPLAYERS O\nFOR O\nWORLD B-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nLISBON B-LOC\n1996-08-23 O\n\nPortugal B-LOC\n's O\nnew O\ncoach O\nArtur B-PER\nJorge I-PER\ncalled O\nup O\nsix O\nplayers O\nfrom O\nleague O\nchampions O\nPorto B-ORG\non O\nFriday O\nin O\nan O\n18-man O\nsquad O\nfor O\nthe O\nopening O\nWorld B-MISC\nCup I-MISC\nqualifier O\nagainst O\nArmenia B-LOC\non O\nAugust O\n31 O\n. O\n\nMidfielder O\nPaulo B-PER\nSousa I-PER\n, O\nrecently O\ntransferred O\nto O\nBorussia B-ORG\nDortmund I-ORG\nfrom O\nItaly B-LOC\n's O\nJuventus B-ORG\n, O\nis O\nthe O\nonly O\nleading O\nmember O\nof O\nthe O\nPortuguese B-MISC\nside O\nfrom O\nthis O\nyear O\n's O\nEuropean B-MISC\nchampionships O\nwho O\nwill O\nnot O\nmake O\nthe O\ntrip O\n. O\n\nIt O\nwill O\nbe O\nJorge B-PER\n's O\nfirst O\ngame O\nin O\ncharge O\nof O\nthe O\nnational O\nsquad O\nsince O\ntaking O\nover O\nfrom O\nAntonio B-PER\nOliveira I-PER\n, O\nwho O\nnow O\ncoaches O\nPorto B-ORG\n, O\nat O\nthe O\nend O\nof O\nEuro B-MISC\n96 I-MISC\n. O\n\nSquad O\n: O\n\nGoalkeepers O\n- O\nVitor B-PER\nBaia I-PER\n, O\nRui B-PER\nCorreia I-PER\n. O\n\nDefenders O\n- O\nJorge B-PER\nCosta I-PER\n, O\nPaulinho B-PER\nSantos I-PER\n, O\nHelder B-PER\nCristovao I-PER\n, O\nCarlos B-PER\nSecretario I-PER\n, O\nDimas B-PER\nTeixeira I-PER\n, O\nFernando B-PER\nCouto I-PER\n. O\n\nMidfielders O\n- O\nJose B-PER\nBarroso I-PER\n, O\nLuis B-PER\nFigo I-PER\n, O\nRui B-PER\nBarros I-PER\n, O\nRui B-PER\nCosta I-PER\n, O\nOceano B-PER\nCruz I-PER\n, O\nRicardo B-PER\nSa I-PER\nPinto I-PER\n. O\n\nForwards O\n- O\nDomingos B-PER\nOliveira I-PER\n, O\nJoao B-PER\nVieira I-PER\nPinto I-PER\n, O\nJorge B-PER\nCadete I-PER\n, O\nAntonio B-PER\nFolha I-PER\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nVOGTS B-PER\nKEEPS O\nFAITH O\nWITH O\nEURO B-MISC\n' I-MISC\n96 I-MISC\nCHAMPIONS O\n. O\n\nBONN B-LOC\n1996-08-23 O\n\nTrainer O\nBerti B-PER\nVogts I-PER\nkept O\nfaith O\nwith O\nhis O\nentire O\nEuropean B-MISC\nchampionship O\nwinning O\nsquad O\nfor O\nGermany B-LOC\n's O\nfirst O\nmatch O\nsince O\ntheir O\ntitle O\nvictory O\n, O\na O\nfriendly O\nin O\nPoland B-LOC\n. O\n\nVogts B-PER\npicked O\nno O\nnew O\nplayers O\nfor O\nthe O\nsquad O\nfor O\nthe O\nSeptember O\n4 O\ngame O\nin O\nZabrze B-LOC\n. O\n\nInstead O\non O\nFriday O\nhe O\nnominated O\nall O\n23 O\nEuro B-MISC\n' I-MISC\n96 I-MISC\nveterans O\nincluding O\nBremen B-ORG\n's O\nJens B-PER\nTodt I-PER\n, O\ncalled O\nup O\nbefore O\nthe O\nfinal O\nby O\nspecial O\nUEFA B-ORG\ndispensation O\n. O\n\nHe O\nwill O\n, O\nhowever O\n, O\nhave O\nto O\ndo O\nwithout O\nthe O\nDortmund B-ORG\ntrio O\nof O\nlibero O\nMatthias B-PER\nSammer I-PER\n, O\nmidfielder O\nSteffen B-PER\nFreund I-PER\nand O\ndefender O\nRene B-PER\nSchneider I-PER\n, O\nwho O\nwere O\nall O\nformally O\nnominated O\ndespite O\nbeing O\ninjured O\n. O\n\n\" O\nThis O\nsquad O\nis O\ncurrently O\nthe O\nbasis O\nof O\nmy O\nplanning O\nfor O\nthe O\n1998 O\nWorld B-MISC\nCup I-MISC\n, O\n\" O\nVogts B-PER\nsaid O\n. O\n\" O\n\nWe O\n'll O\nhave O\nto O\nsee O\nwhich O\nother O\nplayers O\nproduce O\ngood O\nleague O\nperformances O\nto O\nplay O\nthemselves O\ninto O\nthe O\nsquad O\n. O\n\" O\n\nSquad O\n: O\n\nGoalkeepers O\n- O\nOliver B-PER\nKahn I-PER\n, O\nAndreas B-PER\nKoepke I-PER\n, O\nOliver B-PER\nReck I-PER\n\nDefenders O\n- O\nMarkus B-PER\nBabbel I-PER\n, O\nThomas B-PER\nHelmer I-PER\n, O\nJuergen B-PER\nKohler I-PER\n, O\nStefan B-PER\nReuter I-PER\n, O\nMatthias B-PER\nSammer I-PER\n, O\nRene B-PER\nSchneider I-PER\n\nMidfielders O\n- O\nMario B-PER\nBasler I-PER\n, O\nMarco B-PER\nBode I-PER\n, O\nDieter B-PER\nEilts I-PER\n, O\nSteffen B-PER\nFreund I-PER\n, O\nThomas B-PER\nHaessler I-PER\n, O\nAndreas B-PER\nMoeller I-PER\n, O\nMehmet B-PER\nScholl I-PER\n, O\nThomas B-PER\nStrunz I-PER\n, O\nJens B-PER\nTodt I-PER\n, O\nChristian B-PER\nZiege I-PER\n\nForwards O\n- O\nOliver B-PER\nBierhoff I-PER\n, O\nFredi B-PER\nBobic I-PER\n, O\nJuergen B-PER\nKlinsmann I-PER\n, O\nStefan B-PER\nKuntz I-PER\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nEUROPEAN B-MISC\nCUP I-MISC\nDRAWS O\nFOR O\nAEK B-ORG\n, O\nOLYMPIAKOS B-ORG\n, O\nPAO B-ORG\n. O\n\nATHENS B-LOC\n1996-08-23 O\n\nFollowing O\nare O\nthe O\nEuropean B-MISC\nsoccer O\n\ndraws O\nfor O\nthe O\nUEFA B-ORG\ncup O\nand O\nthe O\ncup O\n's O\nwinners O\ncup O\ninvolving O\nGreek B-MISC\n\nteams O\nthat O\ntook O\nplace O\ntoday O\nin O\nGeneva B-LOC\n: O\n\nx-AEK B-ORG\nAthens I-ORG\n( O\nGreece B-LOC\n) O\nv O\nChemlon B-ORG\nHumenne I-ORG\n( O\nSlovakia B-LOC\n) O\n\nx-Olympiakos B-ORG\nv O\nFerencvaros B-ORG\n( O\nHungary B-LOC\n) O\n\nx-PAO B-ORG\nv O\nLegia B-ORG\nWarsaw I-ORG\n( O\nPoland B-LOC\n) O\n\nx O\nindicates O\nseeded O\nteams O\n. O\n\n-- O\nDimitris B-PER\nKontogiannis I-PER\n, O\nAthens B-ORG\nNewsroom I-ORG\n+301 O\n3311812-4 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nEURO B-MISC\nCLUB O\nCOMPETITION O\nFIRST O\nROUND O\nDRAWS O\n. O\n\nGENEVA B-LOC\n1996-08-23 O\n\nDraws O\nfor O\nthe O\nfirst O\nround O\nof O\nthe O\nEuropean B-MISC\nclub O\nsoccer O\ncompetitions O\nmade O\non O\nFriday O\n( O\nx O\ndenotes O\nseeded O\nteam O\n) O\n: O\n\nUEFA B-MISC\nCup I-MISC\nLyngby B-ORG\n( O\nDenmark B-LOC\n) O\nv O\nx-Club B-ORG\nBrugge I-ORG\n( O\nBelgium B-LOC\n) O\nCasino B-ORG\nGraz I-ORG\n( O\nAustria B-LOC\n) O\nv O\nEkeren B-ORG\n( O\nBelgium B-LOC\n) O\nBesiktas B-ORG\n( O\nTurkey B-LOC\n) O\nv O\nMolenbeek B-ORG\n( O\nBelgium B-LOC\n) O\nAlania B-ORG\nVladikavkaz I-ORG\n( O\nRussia B-LOC\n) O\nv O\nx-Anderlecht B-ORG\n( O\nBelgium B-LOC\n) O\n\nCup B-MISC\nWinners I-MISC\n' I-MISC\nCup I-MISC\nx-Cercle B-ORG\nBrugge I-ORG\n( O\nBelgium B-LOC\n) O\nv O\nBrann B-ORG\nBergen I-ORG\n( O\nNorway B-LOC\n) O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nSRI B-LOC\nLANKA I-LOC\nAND O\nAUSTRALIA B-LOC\nSAY O\nRELATIONS O\nHAVE O\nHEALED O\n. O\n\nCOLOMBO B-LOC\n1996-08-23 O\n\nSri B-LOC\nLanka I-LOC\nand O\nAustralia B-LOC\nagreed O\non O\nFriday O\nthat O\nrelations O\nbetween O\nthe O\ntwo O\nteams O\nhad O\nhealed O\nsince O\nthe O\nSri B-MISC\nLankans I-MISC\n' O\nacrimonious O\ntour O\nlast O\nyear O\n. O\n\nThe O\nSri B-MISC\nLankans I-MISC\nwere O\nfirst O\nfound O\nguilty O\nthen O\ncleared O\nof O\nball O\ntampering O\nand O\noff-spinner O\nMuttiah B-PER\nMuralitharan I-PER\nwas O\ncalled O\nfor O\nthrowing O\nduring O\na O\ncontroversial O\nthree-test O\nseries O\nin O\nAustralia B-LOC\n. O\n\n\" O\nOur O\nconcern O\nis O\nto O\nget O\nout O\nthere O\nand O\nplay O\nproper O\ncricket O\n, O\n\" O\nSri B-LOC\nLanka I-LOC\ncaptain O\nArjuna B-PER\nRanatunga I-PER\ntold O\na O\nnews O\nconference O\non O\nthe O\neve O\nof O\na O\nwarmup O\nmatch O\nbetween O\nthe O\nWorld B-MISC\nCup I-MISC\nchampions O\nand O\na O\nWorld B-ORG\nXI I-ORG\nteam O\nscheduled O\nfor O\nSaturday O\n. O\n\n\" O\nWhat O\nhappened O\nis O\nhistory O\n. O\n\" O\n\nAustralian B-MISC\nteam O\nmanager O\nCam B-PER\nBattersby I-PER\nsaid O\nhe O\nagreed O\nwith O\nRanatunga B-PER\n. O\n\n\" O\nI O\nbelieve O\nrelations O\nbetween O\nthe O\ntwo O\nteams O\nwill O\nbe O\nexcellent O\n, O\n\" O\nBatterby B-PER\nsaid O\n. O\n\nThe O\nAustralians B-MISC\nare O\nmaking O\ntheir O\nfirst O\nvisit O\nto O\nthe O\nIndian B-LOC\nOcean I-LOC\nisland O\nsince O\nboycotting O\na O\nWorld B-MISC\nCup I-MISC\nfixture O\nin O\nFebruary O\nafter O\na O\nterrorist O\nbomb O\nin O\nColombo B-LOC\n. O\n\nAustralia B-LOC\nhave O\nbeen O\npromised O\nthe O\npresence O\nof O\ncommandos O\n, O\nsniffer O\ndogs O\nand O\nplainclothes O\npolicemen O\nto O\nensure O\na O\nlimited O\novers O\ntournament O\nis O\ntrouble-free O\n. O\n\nThe O\ntournament O\n, O\nstarting O\non O\nAugust O\n26 O\n, O\nalso O\nincludes O\nIndia B-LOC\nand O\nZimbabwe B-LOC\n. O\n\nBattersby B-PER\nsaid O\nhe O\nwas O\nsatisfied O\nwith O\nthe O\nsecurity O\narrangements O\n. O\n\nSri B-MISC\nLankan I-MISC\nofficials O\nsaid O\nthey O\nexpected O\nheavy O\nrain O\nwhich O\nwashed O\nout O\na O\nwarmup O\nmatch O\non O\nFriday O\nshould O\ncease O\nby O\nSaturday O\n. O\n\nAustralia B-LOC\n, O\nled O\nby O\nwicketkeeper O\nIan B-PER\nHealy I-PER\n, O\nopened O\ntheir O\nshort O\ntour O\nof O\nSri B-LOC\nLanka I-LOC\nwith O\na O\nfive-run O\nwin O\nover O\nthe O\ncountry O\n's O\nyouth O\nteam O\non O\nThursday O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nANGOLA B-LOC\n- O\nAUG O\n23 O\n. O\n\nLUANDA B-LOC\n1996-08-23 O\n\nThese O\nare O\nthe O\nleading O\nstories O\nin O\nthe O\nAngolan B-MISC\npress O\non O\nFriday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\n- O\n- O\n- O\n- O\n\nJORNAL B-ORG\nDE I-ORG\nANGOLA I-ORG\n\n- O\nThe O\nAngolan B-MISC\nChief O\nof O\nState O\naddressed O\na O\nletter O\nto O\nUN B-ORG\nSecurity I-ORG\nCouncil I-ORG\nproposing O\ndates O\nfor O\nthe O\nconclusion O\nof O\nthe O\npeace O\nprocess O\nin O\nAngola B-LOC\n. O\n\nHe O\nproposed O\ndefinite O\ndates O\n, O\nAugust O\n25 O\nfor O\nreturn O\nof O\nUnita B-ORG\ngenerals O\nto O\nthe O\njoint O\narmy O\n, O\nSeptember O\n5 O\nfor O\nthe O\nbeginning O\nof O\nthe O\nformation O\nof O\nthe O\nGovernment B-ORG\nof I-ORG\nNational I-ORG\nUnity I-ORG\nand I-ORG\nReconciliation I-ORG\n. O\n\nUntil O\nthis O\ndate O\nthe O\nfree O\ncirculation O\nof O\npeoples O\nand O\ngoods O\nshould O\nbe O\nguaranteed O\n, O\nthe O\ngovernment O\nadministration O\ninstalled O\nin O\nall O\nareas O\nand O\nthe O\nUnita B-ORG\ndeputies O\nshould O\noccupy O\ntheir O\nplaces O\nin O\nthe O\nNational B-ORG\nAssembly I-ORG\n. O\n\nThe O\npresident O\njustified O\nhis O\nproposal O\nby O\nthe O\ndelays O\nverified O\nin O\nthe O\npeace O\nprocess O\n, O\nincluding O\nthe O\nfact O\nthat O\nareas O\nunder O\nUnita B-ORG\ncontrol O\nor O\noccupation O\nhave O\nnot O\nbeen O\neffectively O\ndemilitarised O\n, O\nwhere O\nthe O\nUnita B-ORG\nmilitary O\nforces O\nhave O\nbeen O\nsubstituted O\nby O\ntheir O\nso-called O\npolice O\n. O\n\n- O\nPresident O\nDos B-PER\nSantos I-PER\nproposes O\nthe O\nestablishment O\nby O\nUN B-ORG\nSecurity I-ORG\nCouncil I-ORG\nof O\ndefinitive O\nand O\nfinal O\ntimetable O\nfor O\nthe O\ntasks O\nand O\nobligations O\nunder O\nthe O\nLusaka B-MISC\nAgreement I-MISC\nand O\nthe O\nsending O\nof O\na O\nmission O\nof O\nSC B-ORG\n, O\nas O\nsoon O\nas O\npossible O\n, O\nto O\nsupervise O\nthe O\nexecution O\nof O\nthe O\nagreement O\n. O\n\n-DOCSTART- O\n\nFORECAST O\n- O\nS.AFRICAN B-MISC\nCOMPANY O\nRESULTS O\nCONSENSUS O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-23 O\n\nAnalysts O\nestimates O\nof O\nmajor O\n\nSouth B-MISC\nAfrican I-MISC\ncompany O\nresults O\nexpected O\nnext O\nweek O\ninclude O\nthe O\n\nfollowing O\n( O\nall O\nfigures O\ncents O\nper O\nshare O\n) O\n: O\n\nDAY--COMPANY----PERIOD--CONSENSUS----RANGE-------PVS O\n\nMON O\nGencor B-ORG\nYR O\nEPS O\n93.12 O\n92.0-94.5 O\n73.8 O\n\nMON O\nGencor B-ORG\nYR O\nDIV O\n25.75 O\n25.0-27.0 O\n20.0 O\n\nMON O\nPrimedia B-ORG\nYR O\nEPS O\nN O\n/ O\nA O\n149.1 O\n\nMON O\nPrimedia B-ORG\nYR O\nDIV O\nN O\n/ O\nA O\n123.2 O\n\nMON O\nDistillers B-ORG\nYR O\nEPS O\nN O\n/ O\nA O\n71.8 O\n\nMON O\nDistillers B-ORG\nYR O\nDIV O\nN O\n/ O\nA O\n49.0 O\n\nTUE O\nIscor B-ORG\nYR O\nEPS O\n29.7 O\n26.0-32.0 O\n38.0 O\n\nTUE O\nIscor B-ORG\nYR O\nDIV O\n15.0 O\n14.5-16.5 O\n16.5 O\n\nTUE O\nMcCarthy B-ORG\nYR O\nEPS O\n125.3 O\n112.0-149.0 O\n93.2 O\n\nTUE O\nMcCarthy B-ORG\nYR O\nDIV O\n36.8 O\n32.0-43.0 O\n28.0 O\n\nWED O\nImphold B-ORG\nYR O\nEPS O\n172.7 O\n170.4-175.0 O\n115.1 O\n\nWED O\nImphold B-ORG\nYR O\nDIV O\n67.5 O\n66.6-68.4 O\n45.0 O\n\nTHU O\nM&R B-ORG\nYR O\nEPS O\n113.0 O\n112.1-113.4 O\n126.0 O\n\nTHU O\nM&R B-ORG\nYR O\nDIV O\n31.7 O\n10.5-42.3 O\n47.0 O\n\nTHU O\nJD B-ORG\nGroup I-ORG\nYR O\nEPS O\n143.7 O\n138.0-149.0 O\n111.2 O\n\nTHU O\nJD B-ORG\nGroup I-ORG\nYR O\nDIV O\n41.8 O\n41.0-42.5 O\n33.0 O\n\nooOOoo O\n\n-- O\nJohannesburg B-LOC\nnewsroom O\n, O\n+27 O\n11 O\n482 O\n1003 O\n\n-DOCSTART- O\n\nUlster B-ORG\nPetroleums I-ORG\nLtd I-ORG\nQ2 O\nnet O\nprofit O\nfalls O\n. O\n\nCALGARY B-LOC\n1996-08-23 O\n\n1996 O\n1995 O\n\nShr O\nC$ B-MISC\n0.04 O\nC$ B-MISC\n0.08 O\n\nNet O\n1,196 O\n2,232 O\n\nCash O\nflow O\n/ O\nshr O\n0.39 O\n0.41 O\n\nRevs O\n20,167 O\n18,623 O\n\n6 O\nMONTHS O\n\nShr O\nC$ B-MISC\n0.12 O\nC$ B-MISC\n0.15 O\n\nNet O\n3,674 O\n4,271 O\n\nCash O\nflow O\n/ O\nshr O\n0.86 O\n0.81 O\n\nRevs O\n41,752 O\n35,711 O\n\n( O\nAll O\ndata O\nabove O\n000s O\nexcept O\nper O\nshare O\nnumbers O\n) O\n\n-- O\nReuters B-ORG\nToronto I-ORG\nBureau I-ORG\n416 O\n941-8100 O\n\n-DOCSTART- O\n\nNigerian B-MISC\nterms O\njeopardize O\nCommonwealth B-ORG\ntrip-Canada B-MISC\n. O\n\nOTTAWA B-LOC\n1996-08-23 O\n\nCommonwealth B-ORG\nministers O\nconcerned O\nabout O\nhuman O\nrights O\nin O\nNigeria B-LOC\nmay O\ncancel O\na O\nplanned O\ntrip O\nthere O\nbecause O\nof O\ngovernment O\nrestrictions O\non O\ntheir O\nmission O\n, O\nCanadian B-MISC\nForeign O\nMinister O\nLloyd B-PER\nAxworthy I-PER\nsaid O\non O\nFriday O\n. O\n\n\" O\nThe O\nreaction O\nof O\nthe O\nregime O\nthere O\nis O\nsuch O\nthat O\nmany O\nof O\nus O\nfeel O\nthat O\nthe O\nmission O\nunder O\nthe O\npresent O\ncircumstances O\nshould O\nn't O\ngo O\nahead O\n, O\n\" O\nAxworthy B-PER\nsaid O\n. O\n\nCommonwealth B-ORG\nforeign O\nministers O\nwill O\nmeet O\nin O\nLondon B-LOC\non O\nWednesday O\nto O\ndiscuss O\nwhat O\nto O\ndo O\n, O\nhe O\nadded O\n. O\n\n-DOCSTART- O\n\nMid-tier O\ngolds O\nup O\nin O\nheavy O\ntrading O\n. O\n\nTORONTO B-LOC\n1996-08-23 O\n\nInvestors O\ngave O\ninto O\ngold O\nfever O\nFriday O\nmorning O\n, O\nwith O\nheavy O\ntrading O\nin O\na O\nhandful O\nof O\nToronto-based B-MISC\ngold O\ncompanies O\n. O\n\nTVX B-ORG\nGold I-ORG\nInc I-ORG\nwas O\nup O\nC$ B-MISC\n0.30 O\nto O\nC$ B-MISC\n11.55 O\nin O\ntrading O\nof O\n780,000 O\nshares O\n, O\nwhile O\nKinross B-ORG\nGold I-ORG\nCorp I-ORG\ngained O\nC$ B-MISC\n0.25 O\nto O\nC$ B-MISC\n11 O\nin O\nvolume O\nof O\n720,000 O\nshares O\n. O\n\nAnd O\nScorpion B-ORG\nMinerals I-ORG\nInc I-ORG\n, O\na O\njunior O\ngold O\nexploration O\ncompany O\nwith O\nfive O\nIndonesian B-MISC\nmining O\nproperties O\n, O\nwas O\nup O\nC$ B-MISC\n0.50 O\nto O\nC$ B-MISC\n6 O\n, O\nwith O\nabout O\n120,000 O\nshares O\nchanging O\nhands O\n. O\n\nTVX B-ORG\nand O\nKinross B-ORG\nrose O\nafter O\nrecent O\nbuy O\nrecommendations O\nfrom O\nU.S. B-LOC\nbrokers O\n, O\nanalysts O\nsaid O\n. O\n\nBut O\nScorpion B-ORG\nwas O\nraising O\na O\nlot O\nof O\neyebrows O\nafter O\nit O\nissued O\na O\nrelease O\nFriday O\nmorning O\nsaying O\nit O\nwas O\nnot O\naware O\nof O\nany O\ndevelopments O\nthat O\ncould O\nhave O\naffected O\nthe O\nstock O\n. O\n\nThe O\ncompany O\nwas O\nformed O\nthis O\nyear O\nand O\na O\ncouple O\nof O\nanalysts O\nhave O\nbeen O\non O\ntheir O\nproperties O\n, O\nsaid O\none O\nanalyst O\n. O\n\nExploration O\nresults O\nare O\nexpected O\nsoon O\n. O\n\n-- O\nReuters B-ORG\nToronto I-ORG\nBureau I-ORG\n416 O\n941-8100 O\n\n-DOCSTART- O\n\nRESEARCH O\nALERT O\n- O\nUnitog B-ORG\nCo I-ORG\nupgraded O\n. O\n\n- O\nBarrington B-ORG\nResearch I-ORG\nAssociates I-ORG\nInc I-ORG\nsaid O\nFriday O\nit O\nupgraded O\nUnitog B-ORG\nCo I-ORG\nto O\na O\nnear-term O\noutperform O\nfrom O\na O\nlong-term O\noutperform O\nrating O\n. O\n\n- O\nAnalyst O\nAlexander B-PER\nParis I-PER\nsaid O\nhe O\nexpected O\nconsistent O\n20 O\npercent O\nearnings O\ngrowth O\nafter O\nan O\nestimated O\ngain O\nof O\n18 O\npercent O\nfor O\n1996 O\n. O\n\n- O\nThe O\nstock O\nclosed O\nunchanged O\nat O\n27 O\n, O\ndown O\nfrom O\na O\nrecent O\nhigh O\nof O\n30 O\n. O\n\n-- O\nChicago B-LOC\nnewsdesk O\n, O\n312-408-8787 O\n\n-DOCSTART- O\n\nBuffett B-PER\nraises O\nProperty B-ORG\nCapital I-ORG\nstake O\n. O\n\nWASHINGTON B-LOC\n1996-08-23 O\n\nOmaha B-LOC\nbillionaire O\nWarren B-PER\nBuffett I-PER\nsaid O\nFriday O\nhe O\nraised O\nhis O\nstake O\nin O\nProperty B-ORG\nCapital I-ORG\nTrust I-ORG\nto O\n8.0 O\npercent O\nfrom O\n6.7 O\npercent O\n. O\n\nIn O\na O\nfiling O\nwith O\nthe O\nSecurities B-ORG\nand I-ORG\nExchnage I-ORG\nCommission I-ORG\n, O\nBuffett B-PER\nsaid O\nhe O\nbought O\n62,900 O\nadditional O\ncommon O\nshares O\nof O\nthe O\nBoston-based B-MISC\nreal O\nestate O\ninvestment O\ntrust O\nat O\nprices O\nranging O\nfrom O\n$ O\n7.65 O\nto O\n$ O\n8.02 O\na O\nshare O\n. O\n\nThe O\npurchases O\nincreased O\nhis O\nholding O\nin O\nthe O\ncompany O\nto O\n725,900 O\nshares O\n, O\nwhich O\nwas O\npurchased O\nfor O\na O\ntotal O\nof O\n$ O\n6.2 O\nmillion O\n, O\nhe O\nsaid O\n. O\n\nBuffett B-PER\n, O\nwho O\nis O\nwell-known O\nas O\na O\nlong-term O\ninvestor O\n, O\nis O\nchairman O\nof O\nBerkshire B-ORG\nHathaway I-ORG\nInc I-ORG\n, O\na O\nholding O\ncompany O\nthrough O\nwhich O\nhe O\nholds O\ninvestments O\nin O\nseveral O\nlarge O\nU.S. B-LOC\ncompanies O\n. O\n\n-DOCSTART- O\n\nColombia B-LOC\n, O\nU.S. B-LOC\nreach O\naviation O\nagreement O\n. O\n\nMIAMI B-LOC\n1996-08-23 O\n\nThe O\nU.S. B-LOC\nand O\nColombian B-MISC\ngovernments O\nreached O\nan O\nagreement O\nthat O\nwill O\nallow O\nAMR B-ORG\nCorp I-ORG\n's O\nAmerican B-ORG\nAirlines I-ORG\nto O\noperate O\nthree O\nround-trip O\nflights O\nbetween O\nNew B-LOC\nYork I-LOC\nand O\nBogota B-LOC\n, O\nthe O\nDepartment B-ORG\nof I-ORG\nTransportation I-ORG\nsaid O\nFriday O\n. O\n\nUnder O\nthe O\nagreement O\n, O\nwhich O\nfollowed O\ntalks O\nin O\nMiami B-LOC\nthis O\nweek O\n, O\nAMR B-ORG\nalso O\nwill O\nbe O\nallowed O\nto O\nshift O\nup O\nto O\nfour O\nof O\nthe O\nweekly O\nflights O\nit O\nnow O\noperates O\nbetween O\nMiami B-LOC\nand O\nColombia B-LOC\nto O\nits O\nNew B-LOC\nYork I-LOC\ngateway O\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\nalso O\nwill O\nbe O\nable O\nto O\ndesignate O\none O\nnew O\nall-cargo O\ncarrier O\nfor O\nservice O\nbetween O\nthe O\ntwo O\nnations O\nafter O\ntwo O\nyears O\n. O\n\nColombia B-LOC\nwas O\npermitted O\nto O\nadd O\na O\nsingle O\nadditional O\nround-trip O\nflight O\nto O\nits O\ncurrent O\nNew B-LOC\nYork I-LOC\nservice O\n, O\nalthough O\nit O\nwill O\nnot O\nbe O\nable O\nto O\ndo O\nso O\nwhile O\nunder O\nCategory O\nTwo O\n( O\nConditional O\n) O\nstatus O\nunder O\nthe O\nFederal B-ORG\nAviation I-ORG\nAdministration I-ORG\n's O\nInternational B-MISC\nAviation I-MISC\nSafety I-MISC\nprogram I-MISC\n. O\n\nColombia B-LOC\nwould O\nbe O\nallowed O\nto O\nadd O\nnew O\nservice O\nwhen O\nits O\nsafety O\nassessment O\nhas O\nbeen O\nimproved O\n, O\nthe O\ndepartment O\nsaid O\n. O\n\nWith O\nthe O\nexception O\nof O\nthe O\nnew O\nservices O\njust O\nagreed O\nto O\n, O\nthe O\ngovernments O\nof O\nthe O\ntwo O\nnations O\nhave O\nagreed O\nto O\nmaintain O\ntheir O\ncurrent O\nlevel O\nof O\nroutes O\nand O\nairlines O\nfor O\nthe O\nnext O\n2-1/2 O\nyears O\n, O\nthe O\nagreement O\nsaid O\n. O\n\nThe O\nagreement O\nresolved O\na O\ndispute O\nthat O\narose O\nin O\nJune O\nwhen O\nColombia B-LOC\nturned O\ndown O\nAmerican B-ORG\n's O\nrequest O\nto O\noperate O\nflights O\nbetween O\nNew B-LOC\nYork I-LOC\nand O\nBogota B-LOC\n, O\na O\ndenial O\nthat O\nprompted O\nthe O\nUnited B-LOC\nStates I-LOC\nto O\ncharge O\nthat O\nthe O\nColombians B-MISC\nwere O\nbreaking O\na O\nbilateral O\naviation O\nagreement O\nand O\nto O\npropose O\nsanctions O\nagainst O\none O\nof O\ntwo O\nColombian B-MISC\nairlines O\n, O\nAvianca B-ORG\nand O\nACES B-ORG\n. O\n\n-DOCSTART- O\n\nClean O\ntanker O\nfixtures O\nand O\nenquiries O\n- O\n1754 O\nGMT B-MISC\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nLATEST O\nFIXTURES O\n\n- O\nMIDEAST B-LOC\nGULF I-LOC\n/ O\nRED B-LOC\nSEA I-LOC\n\nKonpolis B-ORG\n75 O\n1/9 O\nMideast B-LOC\n/ O\nIndonesia B-LOC\nW112.5 O\nKPC B-ORG\n. O\n\nTBN B-ORG\n30 O\n6/9 O\nMideast B-LOC\n/ O\nW.C. B-LOC\nIndia I-LOC\nW200 O\n, O\nE.C.India B-LOC\nW195 O\nIOC B-ORG\n. O\n\n- O\nASIA B-LOC\nPACIFIC I-LOC\n\nPetrobulk B-ORG\nRainbow I-ORG\n28 O\n24/8 O\nOkinawa B-LOC\n/ O\nInchon B-LOC\n$ O\n190,000 O\nHonam B-ORG\n. O\n\n- O\nMED B-LOC\n/ O\nBLACK B-LOC\nSEA I-LOC\n\nTBN B-ORG\n30 O\n15/9 O\nConstanza B-LOC\n/ O\nInia B-LOC\n$ O\n700,000 O\nIOC B-ORG\n. O\n\n- O\nUK B-LOC\n/ O\nCONT O\n\nPort B-ORG\nChristine I-ORG\n36,5 O\n3/9 O\nPembroke B-LOC\n/ O\nUS B-LOC\nW145 O\nStentex B-ORG\n. O\n\n- O\nWESTERN B-LOC\nHEMISPHERE I-LOC\n\nKpaitan B-ORG\nStankov I-ORG\n69 O\n31/8 O\nSt B-LOC\nCroix I-LOC\n/ O\nUSAC B-LOC\nW125 O\nHess B-ORG\n. O\n\nAP B-ORG\nMoller I-ORG\n30 O\n31/8 O\nCaribs B-LOC\n/ O\nJapan B-LOC\n$ O\n875,000 O\nBP B-ORG\n. O\n\nTiber B-ORG\n29 O\n2/9 O\nCaribs B-LOC\n/ O\noptions O\nW265 O\nStinnes B-ORG\n. O\n\n------------------------------------------------------------ O\n\n- O\nMIDDAY O\nFIXTURES O\n\n- O\nMIDEAST B-LOC\nGULF I-LOC\n/ O\nRED B-LOC\nSEA I-LOC\n\nTenacity B-ORG\n70 O\n24/08 O\nMideast B-LOC\n/ O\nSouth B-LOC\nKorea I-LOC\nW145 O\nSamsung B-ORG\n. O\n\nSKS B-ORG\nTana I-ORG\n70 O\n03/09 O\nMideast B-LOC\n/ O\nJapan B-LOC\nW145 O\nCNR B-ORG\n. O\n\nNorthsea B-ORG\nChaser I-ORG\n55 O\n12/09 O\nMideast B-LOC\n/ O\nJapan B-LOC\nW167.5 O\nJomo B-ORG\n. O\n\nSibonina B-ORG\n55 O\n13/09 O\nRed B-LOC\nSea I-LOC\n/ O\nJapan B-LOC\nW160 O\nMarubeni B-ORG\n. O\n\n- O\nASIA B-LOC\n/ O\nPACIFIC B-LOC\n\nNeptune B-ORG\nCrux I-ORG\n30 O\n02/09 O\nSingapore B-LOC\n/ O\noptions O\n$ O\n185,000 O\nSietco B-ORG\n. O\n\nWorld B-ORG\nBridge I-ORG\n30 O\n03/09 O\nSouth B-LOC\nKorea I-LOC\n/ O\nJapan B-LOC\nrnr O\nCNR B-ORG\n. O\n\nFulmar B-ORG\n30 O\n28/08 O\nUlsan B-LOC\n/ O\nYosu B-LOC\n$ O\n105,000 O\nLG B-ORG\nCaltex I-ORG\n. O\n\n- O\nMED B-LOC\n/ O\nBLACK B-LOC\nSEA I-LOC\n\nHemina B-ORG\n33 O\n05/09 O\nEleusis B-ORG\n/ O\nUKCM B-ORG\nW155 O\nCNR B-ORG\n. O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n, O\n+44 O\n171 O\n542 O\n8980 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\n229-1 O\nV O\nENGLAND B-LOC\n- O\nclose O\n. O\n\nSaeed B-PER\nAnwar I-PER\nnot O\nout O\n116 O\n\nAamir B-PER\nSohail I-PER\nc O\nCork B-PER\nb O\nCroft B-PER\n46 O\n\nIjaz B-PER\nAhmed I-PER\nnot O\nout O\n58 O\n\nExtras O\n9 O\n\nFall O\nof O\nwicket O\n- O\n1-106 O\n\nTo O\nbat O\n- O\nInzamam-ul-Haq B-PER\n, O\nSalim B-PER\nMalik I-PER\n, O\nAsif B-PER\nMujtaba I-PER\n, O\nWasim B-PER\nAkram I-PER\n, O\nMoin B-PER\nKhan I-PER\n, O\nMushtaq B-PER\nAhmed I-PER\n, O\nWaqar B-PER\nYounis I-PER\n, O\nMohammad B-PER\nAkam I-PER\n\nEngland B-LOC\n326 O\nall O\nout O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nGolf O\n: O\nNorman B-PER\nsacks O\nhis O\ncoach O\nafter O\ndisappointing O\nseason O\n. O\n\nSYDNEY B-LOC\n1996-08-23 O\n\nWorld O\nnumber O\none O\ngolfer O\nGreg B-PER\nNorman I-PER\nhas O\nsacked O\nhis O\ncoach O\nButch B-PER\nHarmon I-PER\nafter O\na O\ndisappointing O\nseason O\n. O\n\n\" O\nButch B-PER\nand O\nI O\nare O\nfinished O\n, O\n\" O\nNorman B-PER\ntold O\nreporters O\non O\nThursday O\nbefore O\nthe O\nstart O\nof O\nthe O\nWorld B-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\nin O\nAkron B-LOC\n, O\nOhio B-LOC\n. O\n\nNorman B-PER\n, O\na O\ntwo-time O\nBritish B-MISC\nOpen I-MISC\nchampion O\n, O\nparted O\nways O\nwith O\nhis O\nlong-time O\nmentor O\nafter O\ndrawing O\na O\nblank O\nin O\nthis O\nyear O\n's O\nfour O\nmajors O\n, O\nwinning O\ntwo O\ntournaments O\nworldwide O\n. O\n\nThe O\nblonde O\nAustralian B-MISC\nopened O\nwith O\na O\nlevel O\npar O\nround O\nof O\n70 O\nin O\nAkron B-LOC\n, O\nleaving O\nhim O\nfour O\nshots O\nadrift O\nof O\nthe O\nleaders O\n, O\nAmericans B-MISC\nBilly B-PER\nMayfair I-PER\nand O\nPaul B-PER\nGoydos I-PER\nand O\nJapan B-LOC\n's O\nHidemichi B-PER\nTanaki I-PER\n. O\n\nOn O\nWednesday O\nNorman B-PER\ndescribed O\nthis O\nyear O\nas O\nhis O\nworst O\non O\nthe O\nprofessional O\ncircuit O\nsince O\n1991 O\n, O\nwhen O\nhe O\nfailed O\nto O\nwin O\na O\ntournament O\n. O\n\n\" O\nMy O\napplication O\nthis O\nyear O\nhas O\nbeen O\nstrange O\n, O\n\" O\nNorman B-PER\nsaid O\n. O\n\" O\n\nMaybe O\nI O\nhave O\nn't O\nbeen O\nas O\nkeyed O\nup O\nas O\nI O\nshould O\nhave O\nbeen O\n. O\n\" O\n\n\" O\nSometimes O\nyou O\ndo O\nn't O\nhave O\nit O\nin O\nyour O\nhead O\nto O\nplay O\n. O\n\nMaybe O\nthis O\nwas O\none O\nof O\nthose O\nyears O\nwhere O\nI O\nwas O\nthere O\n, O\nbut O\nI O\nwas O\nn't O\n100 O\npercent O\nthere O\n, O\nand O\nyou O\nhave O\nto O\nbe O\n100 O\npercent O\nto O\nperform O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373-1800 O\n\n-DOCSTART- O\n\nSoccer O\n- O\nArab B-MISC\nteam O\nbreaks O\nnew O\nground O\nin O\nIsrael B-LOC\n. O\n\nOri B-PER\nLewis I-PER\n\nTAIBE B-LOC\n, O\nIsrael B-LOC\n1996-08-23 O\n\nFor O\nthe O\nfirst O\ntime O\nin O\nIsraeli B-MISC\nhistory O\n, O\nan O\nArab B-MISC\nteam O\nwill O\ntake O\nthe O\nfield O\nwhen O\nthe O\nNational B-MISC\nLeague I-MISC\nsoccer O\nseason O\nstarts O\non O\nSaturday O\n. O\n\nHapoel B-ORG\nTaibe I-ORG\nfields O\nfour O\nJewish B-MISC\nplayers O\nand O\ntwo O\nforeign O\nimports O\n-- O\na O\nPole B-MISC\nand O\na O\nRomanian B-MISC\n. O\n\nThe O\nrest O\nof O\nthe O\nside O\nis O\nmade O\nup O\nmainly O\nof O\nMoslem B-MISC\nArabs I-MISC\n. O\n\nThe O\nclub O\n, O\nfounded O\nin O\n1961 O\n, O\nhas O\na O\nloyal O\nfollowing O\nin O\nTaibe B-LOC\n, O\nan O\nArab B-MISC\ntown O\nof O\n28,000 O\nin O\nthe O\nheart O\nof O\nIsrael B-LOC\n. O\n\nBut O\naway O\nfrom O\ntheir O\nhome O\nground O\n, O\nthey O\nface O\nunfriendly O\ncrowds O\nwho O\ntaunt O\nthe O\nplayers O\nwith O\nracist O\nabuse O\n. O\n\n\" O\nThe O\nvery O\nfirst O\nthing O\nwe O\nthought O\nabout O\nafter O\nwe O\nknew O\nwe O\nwould O\nbe O\npromoted O\nwas O\nthe O\ngame O\nagainst O\nBetar B-ORG\nJerusalem I-ORG\n, O\n\" O\nsaid O\nTaibe B-ORG\nsupporter O\nKarem B-PER\nHaj I-PER\nYihye I-PER\n. O\n\nTwo O\nweeks O\nago O\nTaibe B-ORG\n, O\ncoached O\nby O\nPole B-MISC\nWojtek B-PER\nLazarek I-PER\n, O\nmet O\nBetar B-ORG\n, O\na O\nclub O\nclosely O\nassociated O\nwith O\nthe O\nright-wing O\nLikud B-ORG\nparty O\n, O\nfor O\nthe O\nfirst O\ntime O\nin O\na O\nCup B-MISC\nmatch O\nin O\nJerusalem B-LOC\n. O\n\nChants O\nfrom O\nthe O\ncrowd O\nof O\n\" O\nDeath O\nto O\nthe O\nArabs B-MISC\n\" O\n, O\nand O\nbottle-throwing O\nduring O\nthe O\ngame O\nmarred O\nthe O\nmatch O\nwhich O\nended O\nin O\na O\ngoalless O\ndraw O\n. O\n\nOne O\nTaibe B-ORG\nsupporter O\nrequired O\nhospital O\ntreatment O\nfor O\ncuts O\nand O\nbruises O\nafter O\na O\nstone O\nstruck O\nhis O\nhead O\nas O\nhe O\nwas O\ndriving O\nfrom O\nthe O\nstadium O\n. O\n\n\" O\nWe O\n're O\nused O\nto O\nhearing O\nthe O\ntaunts O\nof O\n\" O\nDeath O\nto O\nthe O\nArabs B-MISC\n' O\n, O\n\" O\nsaid O\nSameh B-PER\nHaj I-PER\nYihye I-PER\n, O\na O\nTaibe B-LOC\nresident O\nwho O\nstudies O\nat O\nJerusalem B-LOC\n's O\nHebrew B-ORG\nUniversity I-ORG\n. O\n\" O\n\nBut O\nwe O\nknow O\nthat O\nthese O\nare O\nonly O\nwords O\n, O\nnobody O\nhas O\ndied O\nfrom O\nhearing O\nthem O\nand O\nit O\nonly O\nmakes O\nus O\nsupport O\nour O\nteam O\nmore O\nvehemently O\n. O\n\" O\n\nThe O\ndusty O\ntown O\nof O\nTaibe B-LOC\nlacks O\nthe O\namenities O\nof O\nJewish B-MISC\ncommunities O\nand O\nmany O\nIsraeli B-MISC\nArabs I-MISC\nhave O\nlong O\ncomplained O\nof O\nstate O\ndiscrimination O\n. O\n\n\" O\nThere O\nare O\nno O\nparks O\nor O\nempty O\nareas O\nof O\nland O\naround O\nhere O\n, O\nso O\nwhen O\nwe O\nwant O\nto O\nplay O\na O\nfriendly O\ngame O\nof O\nsoccer O\nwe O\nall O\nload O\nup O\nin O\nthe O\ncar O\nand O\ntravel O\nto O\nTel B-LOC\nAviv I-LOC\n, O\n\" O\n60 O\nkm O\n( O\n36 O\nmiles O\n) O\naway O\n, O\nSameh B-PER\nHaj I-PER\nYihye I-PER\nsaid O\n. O\n\nThe O\ntown O\n's O\nramshackle O\n2,500-seat O\nground O\nis O\naccessible O\nonly O\nby O\ntwo O\ndirt O\ntracks O\n. O\n\n\" O\nWe O\nplan O\nto O\nbuild O\na O\n10,000-seat O\nstadium O\n, O\nbut O\nit O\nmay O\nwell O\nbe O\nsituated O\nelsewhere O\n, O\n\" O\nsaid O\nclub O\nchairman O\nAbdul B-PER\nRahman I-PER\nHaj I-PER\nYihye I-PER\n. O\n\" O\n\nWe O\nwill O\ndiscuss O\nthis O\nwith O\nthe O\nmayor O\nand O\nhopefully O\na O\nnew O\nor O\nrefurbished O\nground O\nwill O\nbe O\ncompleted O\nby O\nthe O\nstart O\nof O\nthe O\nnew O\nyear O\n. O\n\" O\n\nIn O\nthe O\nmeantime O\n, O\nTaibe B-ORG\nwill O\nplay O\nall O\ntheir O\nheavily O\npoliced O\nhome O\nmatches O\nat O\nthe O\nJewish B-MISC\ncoastal O\ntown O\nof O\nNetanya B-LOC\n. O\n\n\" O\nWe O\nare O\nIsraelis B-MISC\n, O\nthere O\nis O\nno O\nquestion O\nabout O\nthat O\n, O\n\" O\nsaid O\nKarem B-PER\nHaj I-PER\nYihye I-PER\n, O\na O\nhotel O\nwaiter O\n. O\n\n\" O\nWe O\ndo O\nn't O\nhave O\nany O\nconnection O\nwith O\nthe O\nPalestinians B-MISC\n, O\nthey O\nlive O\nover O\nthere O\n, O\n\" O\nhe O\nsaid O\n, O\npointing O\nto O\nthe O\nWest B-LOC\nBank I-LOC\nseven O\nkm O\n( O\nfour O\nmiles O\n) O\nto O\nthe O\neast O\n. O\n\n\" O\nWe O\ndo O\nn't O\nfeel O\nour O\nclub O\nrepresents O\nPalestinian B-MISC\nArabs I-MISC\n, O\n\" O\nsaid O\nclub O\nchairman O\nAbdul B-PER\nRahman I-PER\n. O\n\" O\n\nWe O\nare O\ntrying O\nto O\ndo O\nall O\nwe O\ncan O\nto O\nrun O\na O\nprofessional O\noutfit O\n, O\nwe O\nare O\npleased O\nat O\nany O\nsupport O\nwe O\nget O\n, O\nbut O\ndo O\nnot O\ngo O\nout O\nlooking O\nto O\nrepresent O\nthe O\nwhole O\nArab B-MISC\nworld O\n. O\n\" O\n\n-DOCSTART- O\n\nSoccer O\n- O\nKennedy B-PER\nand O\nPhelan B-PER\nboth O\nout O\nof O\nIrish B-MISC\nsquad O\n. O\n\nDUBLIN B-LOC\n1996-08-23 O\n\nTwo O\nplayers O\nhave O\nwithdrawn O\nfrom O\nthe O\nRepublic B-LOC\nof I-LOC\nIreland I-LOC\nsquad O\nfor O\nthe O\n1998 O\nWorld B-MISC\nCup I-MISC\nqualifying O\nmatch O\nagainst O\nLiechenstein B-LOC\non O\nAugust O\n31 O\n, O\nthe O\nFootball B-ORG\nAssociation I-ORG\nof I-ORG\nIreland I-ORG\nsaid O\nin O\na O\nstatement O\non O\nFriday O\n. O\n\nThe O\nF.A.I. B-ORG\nstatement O\nsaid O\nthat O\nLiverpool B-ORG\nstriker O\nMark B-PER\nKennedy I-PER\nand O\nChelsea B-ORG\ndefender O\nTerry B-PER\nPhelan I-PER\nwere O\nboth O\nreceiving O\ntreatment O\nfor O\ninjuries O\nand O\nwould O\nnot O\nbe O\ntravelling O\nto O\nLiechenstein B-LOC\nfor O\nthe O\ngame O\n. O\n\nNo O\nreplacements O\nhad O\nbeen O\nnamed O\n. O\n\n-- O\nDamien B-PER\nLynch I-PER\n, O\nDublin B-ORG\nNewsroom I-ORG\n+353 O\n1 O\n6603377 O\n\n-DOCSTART- O\n\nSoccer O\n- O\nManchester B-ORG\nUnited I-ORG\nface O\nJuventus B-ORG\nin O\nEurope B-LOC\n. O\n\nGENEVA B-LOC\n1996-08-23 O\n\nEuropean B-MISC\nchampions O\nJuventus B-ORG\nwill O\nface O\nEnglish B-MISC\nleague O\nand O\ncup O\ndouble O\nwinners O\nManchester B-ORG\nUnited I-ORG\nin O\nthis O\nseason O\n's O\nEuropean B-MISC\nChampions I-MISC\n' I-MISC\nLeague I-MISC\n. O\n\nThe O\ndraw O\nmade O\non O\nFriday O\npitted O\nJuventus B-ORG\n, O\nwho O\nbeat O\nDutch B-MISC\nchampions O\nAjax B-ORG\nAmsterdam I-ORG\n4-2 O\non O\npenalties O\nin O\nlast O\nyear O\n's O\nfinal O\n, O\nagainst O\nAlex B-PER\nFerguson I-PER\n's O\nEuropean B-MISC\nhopefuls O\nin O\ngroup O\nC O\n. O\n\nThe O\nother O\ntwo O\nteams O\nin O\nthe O\ngroup O\nare O\nlast O\nseason O\n's O\nCup B-MISC\nWinners I-MISC\n' I-MISC\nCup I-MISC\nrunners-up O\nRapid B-ORG\nVienna I-ORG\nand O\nFenerbahce B-ORG\nof O\nTurkey B-LOC\n. O\n\nJuventus B-ORG\nmeet O\nUnited B-ORG\nin O\nTurin B-LOC\non O\nSeptember O\n11 O\n, O\nwith O\nthe O\nreturn O\nmatch O\nat O\nOld B-LOC\nTrafford I-LOC\non O\nNovember O\n20 O\n. O\n\nUnited B-ORG\nhave O\ndominated O\nthe O\npremier O\nleague O\nin O\nthe O\n1990s O\n, O\nwinning O\nthree O\nEnglish B-MISC\nchampionships O\nin O\nfour O\nyears O\n, O\nbut O\nhave O\nconsistently O\nfailed O\nin O\nEurope B-LOC\n, O\ncrashing O\nout O\nof O\nthe O\nEuropean B-MISC\nCup I-MISC\nto O\nGalatasaray B-ORG\nof O\nTurkey B-LOC\nand O\nSpain B-LOC\n's O\nBarcelona B-ORG\nat O\ntheir O\nlast O\ntwo O\nattempts O\n. O\n\nThey O\nhave O\nnot O\nlifted O\na O\nEuropean B-MISC\nTrophy I-MISC\nsince O\n1991 O\nwhen O\nthey O\nbeat O\nBarcelona B-ORG\nin O\nthe O\nCup B-MISC\nWinners I-MISC\n' I-MISC\nCup I-MISC\nfinal O\n, O\nand O\ntheir O\none O\nand O\nonly O\nEuropean B-MISC\nCup I-MISC\ntriumph O\nwas O\nway O\nback O\nin O\n1968 O\n, O\nwhen O\nthey O\nbeat O\nBenfica B-ORG\nof O\nPortugal B-LOC\n4-1 O\nat O\nWembley B-LOC\n. O\n\nJuventus B-ORG\nhave O\nwon O\nthe O\nEuropean B-MISC\nCup I-MISC\ntwice O\n. O\n\nBefore O\nconquering O\nAjax B-ORG\nlast O\nyear O\nthey O\nbeat O\nUnited B-ORG\n's O\nbig O\nEnglish B-MISC\nrivals O\nLiverpool B-ORG\nin O\nthe O\nill-fated O\n1985 O\nfinal O\nin O\nthe O\nHeysel B-LOC\nstadium O\nin O\nBrussels B-LOC\n. O\n\n-DOCSTART- O\n\nNigeria B-LOC\npolice O\nkill O\nsix O\nrobbery O\nsuspects O\n. O\n\nLAGOS B-LOC\n1996-08-23 O\n\nNigerian B-MISC\npolice O\nshot O\ndead O\nsix O\nrobbery O\nsuspects O\nas O\nthey O\ntried O\nto O\nescape O\nfrom O\ncustody O\nin O\nthe O\nnorthern O\ncity O\nof O\nSokoto B-LOC\n, O\nthe O\nnational O\nnews O\nagency O\nreported O\non O\nFriday O\n. O\n\nThe O\nNews B-ORG\nAgency I-ORG\nof I-ORG\nNigeria I-ORG\n( O\nNAN B-ORG\n) O\nquoted O\npolice O\nspokesman O\nUmar B-PER\nShelling I-PER\nas O\nsaying O\nthe O\nsix O\nwere O\nkilled O\non O\nWednesday O\n. O\n\nThey O\nhad O\nbeen O\narrested O\nlast O\nweek O\nfor O\nstealing O\n800,000 O\nnaira O\n( O\n$ O\n10,000 O\n) O\nfrom O\na O\nsheep O\nmerchant O\n. O\n\n-DOCSTART- O\n\nRwandan B-MISC\ngroup O\nsays O\nexpulsion O\ncould O\nbe O\nimminent O\n. O\n\nNAIROBI B-LOC\n1996-08-23 O\n\nRepatriation O\nof O\n1.1 O\nmillion O\nRwandan B-MISC\nHutu I-MISC\nrefugees O\nannounced O\nby O\nZaire B-LOC\nand O\nRwanda B-LOC\non O\nThursday O\ncould O\nstart O\nwithin O\nthe O\nnext O\nfew O\ndays O\n, O\nan O\nexiled O\nRwandan B-MISC\nHutu I-MISC\nlobby O\ngroup O\nsaid O\non O\nFriday O\n. O\n\nInnocent B-PER\nButare I-PER\n, O\nexecutive O\nsecretary O\nof O\nthe O\nRally B-ORG\nfor I-ORG\nthe I-ORG\nReturn I-ORG\nof I-ORG\nRefugees I-ORG\nand I-ORG\nDemocracy I-ORG\nin I-ORG\nRwanda I-ORG\n( O\nRDR B-ORG\n) O\nwhich O\nsays O\nit O\nhas O\nthe O\nsupport O\nof O\nRwanda B-LOC\n's O\nexiled O\nHutus B-MISC\n, O\nappealed O\nto O\nthe O\ninternational O\ncommunity O\nto O\ndeter O\nthe O\ntwo O\ncountries O\nfrom O\ngoing O\nahead O\nwith O\nwhat O\nit O\ntermed O\na O\n\" O\nforced O\nand O\ninhuman O\naction O\n\" O\n. O\n\n-DOCSTART- O\n\nOrthodox O\nchurch O\nblown O\nup O\nin O\nsouthern O\nCroatia B-LOC\n. O\n\nZAGREB B-LOC\n1996-08-23 O\n\nSaboteurs O\nblew O\nup O\na O\nSerb B-MISC\northodox O\nchurch O\nin O\nsouthern O\nCroatia B-LOC\non O\nFriday O\nwith O\na O\nblast O\nwhich O\nalso O\ndamaged O\nfour O\nnearby O\nhomes O\n, O\nthe O\nstate O\nnews O\nagency O\nHina B-ORG\nreported O\n. O\n\nHINA B-ORG\nsaid O\nthe O\nchurch O\nin O\nthe O\nsmall O\nvillage O\nof O\nKarin B-LOC\nGornji I-LOC\n, O\n30 O\nkm O\n( O\n19 O\nmiles O\n) O\nnorth O\nof O\nZadar B-LOC\n, O\nwas O\ndestroyed O\nby O\nthe O\nmorning O\nattack O\n. O\n\nIt O\ndid O\nnot O\nreport O\nany O\ncasualties O\n. O\n\nZadar B-LOC\npolice O\nsaid O\nin O\na O\nstatement O\nthey O\nhad O\nlaunched O\nan O\ninvestigation O\nand O\nwere O\ndoing O\ntheir O\nbest O\nto O\nfind O\nthe O\nperpetrators O\n. O\n\nHINA B-ORG\nsaid O\nit O\nwas O\nthe O\nfirst O\ntime O\nan O\northodox O\nchurch O\nhad O\nbeen O\nblown O\nup O\nin O\nthe O\nZadar B-LOC\nhinterland O\n, O\nwhere O\na O\nlarge O\nnumber O\nof O\nSerbs B-MISC\nlived O\nbefore O\nthe O\n1991 O\nwar O\nover O\nCroatia B-LOC\n's O\nindependence O\nfrom O\nthe O\nYugoslav B-MISC\nfederation O\n. O\n\nThe O\narea O\nwas O\npart O\nof O\nthe O\nself-styled O\nstate O\nof O\nKrajina B-LOC\nproclaimed O\nby O\nminority O\nSerbs B-MISC\nin O\n1991 O\nand O\nrecaptured O\nby O\nthe O\nCroatian B-MISC\narmy O\nlast O\nyear O\n. O\n\nUp O\nto O\n200,000 O\nSerbs B-MISC\nfled O\nto O\nBosnia B-LOC\nand O\nYugoslavia B-LOC\n, O\nleaving O\nKrajina B-LOC\nvacant O\nand O\ndepopulated O\n. O\n\n-DOCSTART- O\n\nHungary B-LOC\n's O\ngross O\nforeign O\ndebt O\nrises O\nin O\nJune O\n. O\n\nBUDAPEST B-LOC\n1996-08-23 O\n\nHungary B-LOC\n's O\ngross O\nforeign O\ndebt O\nrose O\nto O\n$ O\n27.53 O\nbillion O\nin O\nJune O\nfrom O\n$ O\n27.25 O\nbillion O\nin O\nMay O\n, O\nthe O\n\nNational B-ORG\nBank I-ORG\nof I-ORG\nHungary I-ORG\n( O\nNBH B-ORG\n) O\nsaid O\non O\nFriday O\n. O\n\nFIGURES O\nIN O\n$ O\nMILLION O\nJune O\n1996 O\nMay O\n1996 O\n\nGross O\nforeign O\ndebt O\n27,535.5 O\n27,246.5 O\n\nInternational O\nreserves O\nand O\n\nother O\nforeign O\nassets O\n13,256.5 O\n12,855.7 O\n\nNet O\nforeign O\ndebt O\n14,278.9 O\n14,390.7 O\n\nNet O\nforeign O\ndebt O\nof O\nthe O\n\ngovernment O\nand O\nNBH B-ORG\n9,510.9 O\n10,056.4 O\n\n-- O\nBudapest B-LOC\nnewsroom O\n( O\n36 O\n1 O\n) O\n266 O\n2410 O\n\n-DOCSTART- O\n\nGermany B-LOC\n, O\nPoland B-LOC\ntighten O\ncooperation O\nagainst O\ncrime O\n. O\n\nWARSAW B-LOC\n1996-08-23 O\n\nGermany B-LOC\nand O\nPoland B-LOC\nagreed O\non O\nFriday O\nto O\ntighten O\ncooperation O\nbetween O\ntheir O\nintelligence O\nservices O\nin O\nfighting O\ninternational O\norganised O\ncrime O\n, O\nPAP B-ORG\nnews O\nagency O\nreported O\n. O\n\nInterior B-ORG\nMinister O\nZbigniew B-PER\nSiemiatkowski I-PER\nand O\nBernd B-PER\nSchmidbauer I-PER\n, O\nGerman B-MISC\nintelligence O\nco-ordinator O\nin O\nHelmut B-PER\nKohl I-PER\n's O\nchancellery O\n, O\nsealed O\nthe O\ncloser O\nlinks O\nduring O\ntalks O\nin O\nWarsaw B-LOC\n. O\n\nMinistry O\nspokesman O\nRyszard B-PER\nHincza I-PER\ntold O\nthe O\nPolish B-MISC\nagency O\nthe O\nservices O\nwould O\nwork O\ntogether O\nagainst O\nmafia-style O\ngroups O\n, O\ndrug O\nsmuggling O\nand O\nillegal O\ntrade O\nin O\narms O\nand O\nradioactive O\nmaterials O\n. O\n\n-DOCSTART- O\n\nRussians B-MISC\n, O\nChechens B-MISC\nsay O\nobserving O\nGrozny B-LOC\nceasefire O\n. O\n\nGROZNY B-LOC\n, O\nRussia B-LOC\n1996-08-23 O\n\nRebel O\nfighters O\nand O\nRussian B-MISC\nsoldiers O\nsaid O\na O\nceasefire O\neffective O\nat O\nnoon O\n( O\n0800 O\nGMT B-MISC\n) O\non O\nFriday O\nwas O\nbeing O\ngenerally O\nobserved O\n, O\nalthough O\nscattered O\ngunfire O\nechoed O\nthrough O\nthe O\nChechen B-MISC\ncapital O\nGrozny B-LOC\n. O\n\nThe O\nRussian B-MISC\narmy O\nsaid O\nearlier O\nit O\nwas O\npreparing O\nto O\nwithdraw O\nfrom O\nthe O\nrebel-dominated O\nsouthern O\nmountains O\nof O\nthe O\nregion O\nas O\npart O\nof O\nthe O\npeace O\ndeal O\nreached O\nwith O\nseparatists O\non O\nThursday O\n. O\n\n\" O\nThere O\nhas O\nbeen O\nsome O\nshooting O\nfrom O\ntheir O\nside O\nbut O\nit O\nhas O\nbeen O\nrelatively O\nquiet O\n, O\n\" O\nsaid O\nfighter O\nAslan B-PER\nShabazov I-PER\n, O\na O\nbearded O\nman O\nwearing O\na O\nwhite O\nt-shirt O\nand O\ncamoflage O\ntrousers O\n. O\n\nSoon O\nafter O\nhe O\nspoke O\nanother O\nburst O\nof O\ngunfire O\nrocked O\nthe O\ncourtyard O\nwhere O\nthe O\nrebels O\nhad O\nset O\nup O\ntheir O\nbase O\nand O\na O\ncaptured O\nRussian B-MISC\nT-72 B-MISC\ntank O\nroared O\nout O\nto O\ninvestigate O\n. O\n\nThe O\nseparatists O\n, O\nwho O\nswept O\ninto O\nGrozny B-LOC\non O\nAugust O\n6 O\n, O\nstill O\ncontrol O\nlarge O\nareas O\nof O\nthe O\ncentre O\nof O\ntown O\n, O\nand O\nRussian B-MISC\nsoldiers O\nare O\nbased O\nat O\ncheckpoints O\non O\nthe O\napproach O\nroads O\n. O\n\n\" O\nThe O\nceasefire O\nis O\nbeing O\nobserved O\n, O\n\" O\nsaid O\nwoman O\nsoldier O\nSvetlana B-PER\nGoncharova I-PER\n, O\n35 O\n, O\nshort O\ndark O\nhair O\npoking O\nout O\nfrom O\nunder O\na O\npeaked O\ncamouflage O\ncap O\n. O\n\nA O\nfew O\nhelicopters O\nflew O\noverhead O\n, O\nfiring O\noff O\nflares O\n, O\nbut O\nthere O\nwas O\nno O\nshooting O\nfrom O\nthe O\nair O\n. O\n\nThe O\ntruce O\n, O\nthe O\nlatest O\nof O\nseveral O\n, O\nwas O\nagreed O\nin O\ntalks O\non O\nThursday O\nbetween O\nRussian B-MISC\npeacemaker O\nAlexander B-PER\nLebed I-PER\nand O\nrebel O\nchief-of-staff O\nAslan B-PER\nMaskhadov I-PER\n. O\n\nThe O\ntwo O\nalso O\nagreed O\nto O\nset O\nup O\njoint O\npatrols O\nin O\nGrozny B-LOC\n, O\nbut O\nGoncharova B-PER\nsaid O\nshe O\nwas O\nsceptical O\nabout O\nwhether O\nthis O\ncould O\nwork O\n. O\n\n\" O\nWe O\nhave O\nto O\ntry O\nit O\n, O\nbut O\nI O\ndoubt O\nif O\nthis O\nis O\npossible O\nwith O\nthe O\nseparatists O\n, O\n\" O\nshe O\nsaid O\n. O\n\n-DOCSTART- O\n\nWEATHER O\n- O\nConditions O\nat O\nCIS B-LOC\nairports O\n- O\nAugust O\n23 O\n. O\n\nMOSCOW B-LOC\n1996-08-23 O\n\nNo O\nclosures O\nof O\nairports O\nin O\nthe O\nCommonwealth B-LOC\nof I-LOC\nIndependent I-LOC\nStates I-LOC\nare O\nexpected O\non O\nAugust O\n24 O\nand O\nAugust O\n25 O\n, O\nthe O\nRussian B-ORG\nWeather I-ORG\nService I-ORG\nsaid O\non O\nFriday O\n. O\n\n-- O\nMoscow B-ORG\nNewsroom I-ORG\n+7095 O\n941 O\n8520 O\n\n-DOCSTART- O\n\nGranic B-PER\narrives O\nto O\nsign O\nCroatia-Yugoslavia B-LOC\ntreaty O\n. O\n\nBELGRADE B-LOC\n1996-08-23 O\n\nYugoslavia B-LOC\nand O\nCroatia B-LOC\nwere O\npoised O\non O\nFriday O\nto O\nsign O\na O\nlandmark O\nnormalisation O\ntreaty O\nending O\nfive O\nyears O\nof O\ntensions O\nand O\npaving O\nway O\nfor O\nstabilisation O\nin O\nthe O\nBalkans B-LOC\n. O\n\nCroatian B-MISC\nForeign O\nMinister O\nMate B-PER\nGranic I-PER\nlanded O\nat O\nBelgrade B-LOC\nairport O\naboard O\na O\nCroatian B-MISC\ngovernment O\njet O\non O\nFriday O\nmorning O\nfor O\ntalks O\nwith O\nhis O\nYugoslav B-MISC\ncounterparts O\nand O\na O\nsigning O\nceremony O\nexpected O\naround O\nnoon O\n( O\n1000 O\nGMT B-MISC\n) O\n. O\n\nOn O\nThursday O\nthe O\nYugoslav B-MISC\ngovernment O\nendorsed O\nthe O\ntext O\nof O\nthe O\nagreement O\non O\nnormalising O\nrelations O\nbetween O\nthe O\ntwo O\ncountries O\n, O\nthe O\nYugoslav B-MISC\nnews O\nagency O\nTanjug B-ORG\nsaid O\n. O\n\n\" O\nThe O\ngovernment O\nassessed O\nthe O\nagreement O\nas O\na O\ncrucial O\nstep O\nto O\nresolving O\nthe O\nYugoslav B-MISC\ncrisis O\n, O\nensuring O\nthe O\nrestoration O\nof O\npeace O\nin O\nformer O\nYugoslavia B-LOC\n, O\n\" O\nit O\nsaid O\n. O\n\nLast-minute O\ntalks O\nthis O\nweek O\non O\nthe O\nlegal O\nfine O\nprint O\nfinally O\ncleared O\nthe O\nway O\nfor O\na O\ntreaty O\nbased O\non O\nmutual O\nrecognition O\nwithin O\ninternationally O\nrecognised O\nborders O\nand O\nthe O\nestablishment O\nof O\ndiplomatic O\nrelations O\n, O\ndiplomats O\nsaid O\n. O\n\nThe O\npact O\nends O\nfive O\nyears O\nof O\nhostility O\nafter O\nCroatia B-LOC\n's O\nsecession O\nfrom O\nfederal O\nYugoslavia B-LOC\n. O\n\nWestern B-MISC\npowers O\nregard O\ndiplomatic O\nnormalisation O\nbetween O\nCroatia B-LOC\nand O\nSerbia B-LOC\n, O\ntwin O\npillars O\nof O\nthe O\nold O\nmultinational O\nfederal O\nYugoslavia B-LOC\n, O\nas O\na O\ncrucial O\nstep O\ntowards O\na O\nlasting O\npeace O\nin O\nthe O\nBalkans B-LOC\n. O\n\n-DOCSTART- O\n\nEcuador B-LOC\npresident O\nto O\nlunch O\nwith O\nethnic O\nIndians B-MISC\n. O\n\nQUITO B-LOC\n, O\nEcuador B-LOC\n1996-08-23 O\n\nEcuador B-LOC\n's O\nPresident O\nAbdala B-PER\nBucaram I-PER\nhas O\nannounced O\nhe O\nwill O\nhold O\nregular O\nlunches O\nin O\nhis O\npresidential O\npalace O\nfor O\nmembers O\nof O\nthe O\ncountry O\n's O\ndifferent O\nethnic O\ngroups O\nas O\nof O\nnext O\nweek O\n. O\n\n\" O\nIt O\nwas O\nabout O\ntime O\nfor O\nthe O\nIndians B-MISC\n, O\nthe O\nblacks O\nand O\nthe O\nmixed-bloods O\nto O\nbegin O\neating O\nin O\nthe O\npalace O\nwith O\ntheir O\npresident O\nbecause O\nthis O\nis O\nnot O\na O\npalace O\nexclusively O\nfor O\nthe O\npotentates O\nand O\nambassadors O\nand O\nprotocol O\n, O\n\" O\nBucaram B-PER\nsaid O\nlate O\non O\nThursday O\n. O\n\n\" O\nIn O\nthese O\nweekly O\nlunches O\nwe O\nare O\ngoing O\nto O\nget O\nto O\nknow O\nthe O\nproblems O\nof O\nthe O\nIndian B-MISC\n, O\nmixed-race O\n, O\nblack O\nand O\npeasant O\nsectors O\n, O\n\" O\nhe O\nsaid O\n. O\n\nHe O\nhas O\ninvited O\n35 O\nIndian B-MISC\nleaders O\nto O\nlunch O\nnext O\nTuesday O\n. O\n\nBucaram B-PER\n, O\nwho O\nwas O\nelected O\non O\na O\npopulist O\nplatform O\nlast O\nmonth O\n, O\nalso O\nplans O\nto O\ncreate O\na O\nministry O\nfor O\nethnic O\ncultures O\n. O\n\nThe O\nAndean B-MISC\nnation O\n's O\npopulation O\nof O\n11.4 O\nmillion O\nis O\n47 O\npercent O\nindigenous O\n. O\n\n-DOCSTART- O\n\nBrazil B-LOC\nto O\nuse O\nhovercrafts O\nfor O\nAmazon B-LOC\ntravel O\n. O\n\nBRASILIA B-LOC\n1996-08-22 O\n\nHovercrafts O\nwill O\nsoon O\nbe O\nplying O\nthe O\nwaters O\nof O\nthe O\nAmazon B-LOC\nin O\na O\nbid O\nto O\nreduce O\nthe O\ndifficulties O\nof O\ntransportation O\non O\nthe O\nvast O\nBrazilian B-MISC\nwaterway O\n, O\nthe O\ngovernment O\nsaid O\non O\nThursday O\n. O\n\nTwo O\nRussian-built B-MISC\nhovercrafts O\n, O\ncapable O\nof O\ncarrying O\nup O\nto O\n50 O\ntons O\neach O\n, O\nwill O\nbegin O\nferrying O\npassengers O\nand O\ncargo O\nup O\nand O\ndown O\nthe O\nhuge O\nriver O\nfrom O\nits O\nmouth O\nat O\nBelem B-LOC\nby O\nthe O\nend O\nof O\nthe O\nyear O\n, O\nBrazil B-LOC\n's O\nAmazon B-ORG\nAffairs I-ORG\nDepartment I-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nuse O\nof O\nriverways O\nin O\nthe O\nregion O\nhas O\nbeen O\nmade O\na O\npriority O\nunder O\na O\ngovernment O\nplan O\nfor O\nthe O\nAmazon B-LOC\nand O\nthe O\nhigh-speed O\nhovercraft O\nwill O\nhelp O\nreduce O\nthe O\ntime O\ninvolved O\nin O\ntravelling O\noften O\nmassive O\ndistances O\n, O\nit O\nsaid O\n. O\n\n-DOCSTART- O\n\nHK B-LOC\n's O\nTsang B-PER\nto O\nvisit O\nIndonesia B-LOC\n, O\nNew B-LOC\nZealand I-LOC\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-23 O\n\nHong B-LOC\nKong I-LOC\nFinancial O\nSecretary O\nDonald B-PER\nTsang I-PER\nwill O\nvisit O\nIndonesia B-LOC\nand O\nNew B-LOC\nZealand I-LOC\nfrom O\nAugust O\n25 O\nto O\n31 O\n, O\nthe O\ngovernment O\nsaid O\non O\nFriday O\n. O\n\nIn O\nJakarta B-LOC\n, O\nTsang B-PER\nwill O\nmeet O\nPresident O\nSuharto B-PER\n, O\nMinister O\nof O\nFinance B-ORG\nMar'ie B-PER\nMuhammad I-PER\n, O\nMinister O\nof O\nForeign B-ORG\nAffairs I-ORG\nAli B-PER\nAlatas I-PER\nand O\nMinister O\nof O\nTrade B-ORG\nand I-ORG\nIndustry I-ORG\nTungky B-PER\nAriwibowo I-PER\n. O\n\nOn O\nhis O\nNew B-LOC\nZealand I-LOC\nleg O\nfrom O\nAugust O\n29 O\n, O\nTsang B-PER\nwill O\nmeet O\nPrime O\nMinister O\nJim B-PER\nBolger I-PER\n, O\nDeputy O\nPrime O\nMinister O\nDon B-PER\nMcKinnon I-PER\nand O\nMinister O\nof O\nFinance B-ORG\nBill B-PER\nBirch I-PER\n. O\n\n-DOCSTART- O\n\nJordan B-LOC\nexpels O\nIraqi B-MISC\ndiplomat O\nafter O\nbread O\nriots O\n. O\n\nRana B-PER\nSabbagh I-PER\n\nAMMAN B-LOC\n1996-08-23 O\n\nJordan B-LOC\n, O\nwhich O\nhas O\nblamed O\nIraq B-LOC\nfor O\nbread O\nriots O\nlast O\nweek O\n, O\nhas O\nasked O\nan O\nIraqi B-MISC\ndiplomat O\nto O\nleave O\n, O\nofficial O\nand O\ndiplomatic O\nsources O\nsaid O\non O\nFriday O\n. O\n\nThe O\nmain O\nFriday O\nprayers O\nin O\nsouthern O\nJordan B-LOC\nthat O\nwere O\nthe O\nstarting O\npoint O\nfor O\nthe O\nriots O\na O\nweek O\nago O\npassed O\npeacefully O\nunder O\ntight O\nsecurity O\nimposed O\nby O\nthe O\narmy O\nwith O\nonly O\nbrief O\ndemonstrations O\nreported O\n. O\n\nAdel B-PER\nIbrahim I-PER\n, O\nthe O\nIraqi B-MISC\nembassy O\n's O\npress O\nattache O\n, O\nwas O\nasked O\nto O\nleave O\n\" O\nbecause O\nhe O\nwas O\ncarrying O\nout O\nduties O\nincompatible O\nwith O\ndiplomatic O\nnorms O\n\" O\n, O\none O\nsource O\ntold O\nReuters B-ORG\n, O\nimplying O\nhe O\nwas O\naccused O\nof O\nspying O\n. O\n\nIbrahim B-PER\ntold O\nReuters B-ORG\nby O\ntelephone O\nfrom O\nhis O\nembassy O\noffice O\nin O\nAmman B-LOC\nthat O\nhe O\n\" O\nhad O\nnot O\nbeen O\nnotified O\n\" O\nof O\nany O\nexplusion O\norder O\n. O\n\nThe O\ngovernment O\ndeclined O\nofficial O\ncomment O\n. O\n\nIbrahim B-PER\n's O\nassistant O\n, O\nHussein B-PER\nKhalaf I-PER\n, O\nwas O\nexpelled O\nearlier O\nthis O\nyear O\nfor O\nsimilar O\nreasons O\namid O\nrising O\ntension O\nin O\nbilateral O\nties O\nafter O\nKing O\nHussein B-PER\nbegan O\ncalling O\nfor O\nchange O\nin O\nBaghdad B-LOC\nfollowing O\ntop O\nIraqi B-MISC\ndefections O\nin O\nAugust O\n1995 O\n. O\n\nIraq B-LOC\nretaliated O\nthen O\nby O\nexpelling O\na O\njunior O\nadministrator O\nworking O\nin O\nthe O\nJordanian B-MISC\nembassy O\nin O\nBaghdad B-LOC\nbut O\nhas O\ncontinued O\nits O\npolicy O\nof O\ntrying O\nto O\navoid O\npublic O\nconflicts O\nwith O\nJordan B-LOC\n-- O\nits O\nonly O\nsecure O\nroute O\nto O\nthe O\nrest O\nof O\nthe O\nworld O\n. O\n\nJordan B-LOC\nhas O\naccused O\nIraq B-LOC\nand O\na O\nlocal O\npro-Baghdad B-MISC\nparty O\nfor O\nthe O\ncountry O\n's O\nworst O\nunrest O\nin O\nseven O\nyears O\nwhich O\nerupted O\nafter O\nit O\nalmost O\ndoubled O\nthe O\nprices O\nof O\nbread O\nlast O\nweek O\nunder O\nradical O\neconomic O\nreforms O\nagreed O\nwith O\nthe O\nInternational B-ORG\nMonetary I-ORG\nFund I-ORG\n. O\n\nIn O\nKarak B-LOC\n, O\nwhere O\ntwo O\ndays O\nof O\nriots O\nflared O\nlast O\nFriday O\n, O\na O\nfew O\nhundred O\nyoung O\nmen O\nlingered O\noutside O\nOmari B-LOC\nmosque O\non O\nleaving O\n, O\nshouting O\nslogans O\nfor O\nabout O\n15 O\nminutes O\n. O\n\n\" O\nDisperse O\n, O\nabstain O\nfrom O\nforming O\ngroups O\nand O\nhelp O\nmaintain O\norder O\n, O\n\" O\narmy O\nofficers O\n, O\nwho O\nhas O\nenforced O\na O\nloose O\ncurfew O\nsince O\nthe O\nriots O\n, O\ntold O\nthe O\ncrowd O\nthrough O\nloudspeakers O\n. O\n\nThe O\nmen O\nshouted O\n\" O\nAllahu B-PER\nAkbar O\n\" O\n( O\nGod B-PER\nis O\nGreatest O\n) O\nas O\na O\nformer O\nIslamist B-MISC\ndeputy O\n, O\nAhmed B-PER\nKafawin I-PER\n, O\ntold O\nsoldiers O\nthe O\ncrowd O\nwould O\nnot O\ncause O\ntrouble O\n. O\n\nHe O\nhad O\nearlier O\nmounted O\nthe O\nmosque O\n's O\npulpit O\nto O\ndemand O\nrelease O\nof O\ndetainees O\n, O\nan O\nend O\nto O\nraids O\non O\nhouses O\nand O\nthe O\ncancelling O\nof O\nthe O\nbread O\nprice O\nrises O\n. O\n\nArmoured O\ncars O\nhad O\npatrolled O\nstreets O\nin O\nKarak B-LOC\n, O\ntraditional O\nbastion O\nof O\ncommunist O\nideology O\nand O\nBaath B-MISC\nsocialism O\nthat O\nswept O\nthe O\nregion O\nin O\nthe O\n1950s O\n, O\nand O\nguarded O\nentrances O\nto O\nthe O\nhill-top O\ncity O\nfamed O\nfor O\nits O\nCrusader O\ncastle O\nbefore O\nthe O\nprayers O\n. O\n\nThere O\nwas O\nalso O\nheavy O\nsecurity O\nin O\nthe O\ncrowded O\ncentre O\nof O\nAmman B-LOC\n, O\nwhere O\nsmaller O\nclashes O\nhad O\nerupted O\nlast O\nSaturday O\n, O\nbut O\nFriday O\nprayers O\nat O\nthe O\nmain O\nmosque O\nended O\nquietly O\nas O\npolice O\nin O\nfull O\nriot O\ngear O\nlooked O\non O\n. O\n\nThe O\nJordanian B-ORG\nArab I-ORG\nSocialist I-ORG\nBaath I-ORG\nParty I-ORG\n, O\nwhich O\nhas O\none O\ndeputy O\nin O\nthe O\n80-seat O\nlower O\nhouse O\nof O\nparliament O\n, O\nhas O\ndenied O\ninvolvement O\nin O\nunrest O\nwhich O\nit O\nblamed O\non O\ngovernment O\npolicies O\nand O\nrising O\neconomic O\nhardship O\n. O\n\nGovernment O\nattempts O\nto O\nlink O\nthe O\nrioting O\nto O\nforeign O\ninfluence O\nhas O\nbeen O\ntreated O\nwith O\nderision O\nby O\nthose O\nin O\nthe O\nstreets O\nwho O\nblame O\nthe O\nprotests O\non O\nsevere O\neconomic O\nhardships O\n. O\n\n-DOCSTART- O\n\nTurkey B-LOC\nsays O\nkilled O\n17 O\nKurd B-MISC\nrebels O\nin O\nclashes O\n. O\n\nANKARA B-LOC\n1996-08-23 O\n\nTurkish B-MISC\ntroops O\nhave O\nkilled O\n17 O\nKurdish B-MISC\nrebels O\nin O\nrecent O\nclashes O\nin O\nthe O\nsoutheast O\nof O\nthe O\ncountry O\n, O\nthe O\nstate-run O\nAnatolian B-ORG\nnews O\nagency O\nsaid O\non O\nFriday O\n. O\n\nTwo O\nsecurity O\nofficials O\nand O\ntwo O\nstate-paid O\nvillage O\nguards O\nwere O\nkilled O\nin O\nthe O\nfighting O\nwith O\nKurdistan B-ORG\nWorkers I-ORG\nParty I-ORG\n( O\nPKK B-ORG\n) O\nguerrillas O\n, O\nthe O\nagency O\nquoted O\nthe O\nemergency O\nrule O\ngovernor O\n's O\noffice O\nas O\nsaying O\n. O\n\nEight O\nof O\nthe O\nrebels O\nwere O\nkilled O\nin O\nVan B-LOC\nprovince O\n, O\nfive O\nin O\nSirnak B-LOC\nand O\nfour O\nin O\nHakkari B-LOC\n. O\n\nThe O\nagency O\ndid O\nnot O\nsay O\nwhen O\nthe O\nclashes O\ntook O\nplace O\n. O\n\nMore O\nthan O\n20,000 O\npeople O\nhave O\ndied O\nin O\nthe O\nPKK B-ORG\n's O\n12-year-old O\nfight O\nfor O\nindependence O\nor O\nautonomy O\nin O\nsoutheastern O\nTurkey B-LOC\n. O\n\nThree O\npeople O\n, O\nincluding O\ntwo O\nvillage O\nguards O\n, O\ndied O\nwhen O\na O\nmine O\nplanted O\nby O\nPKK B-ORG\nrebels O\nexploded O\non O\na O\nroad O\nin O\nthe O\nsoutheast O\n, O\nAnatolian B-ORG\nreported O\nearlier O\n. O\n\nIt O\nsaid O\na O\ntaxi O\ncarrying O\nthe O\nguards O\n, O\nmembers O\nof O\na O\nmostly O\nKurdish B-MISC\nmilitia O\nwhich O\nfights O\nthe O\nPKK B-ORG\n, O\nhit O\nthe O\nmine O\nin O\nthe O\nprovince O\nof O\nDiyarbakir B-LOC\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nsays O\nIraqi B-MISC\nKurds I-MISC\nagree O\nceasefire O\n. O\n\nWASHINGTON B-LOC\n1996-08-23 O\n\nLeaders O\nof O\nIraq B-LOC\n's O\ntwo O\nmain O\nKurdish B-MISC\nfactions O\nagreed O\non O\nFriday O\nto O\nend O\nsix O\ndays O\nof O\nfighting O\nand O\nto O\nattend O\nU.S.-mediated B-MISC\npeace O\ntalks O\nnext O\nmonth O\n, O\nthe O\nState B-ORG\nDepartment I-ORG\nsaid O\n. O\n\nSpokesman O\nGlyn B-PER\nDavies I-PER\nsaid O\nin O\na O\nstatement O\nthat O\nthe O\nagreement O\nfollowed O\ndirect O\nU.S. B-LOC\ncontacts O\nwith O\nMassoud B-PER\nBarzani I-PER\n, O\nleader O\nof O\nthe O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nKDP B-ORG\n) O\n, O\nand O\nJalal B-PER\nTalabani I-PER\n, O\nleader O\nof O\nthe O\nPatriotic B-ORG\nUnion I-ORG\nof I-ORG\nKurdistan I-ORG\n( O\nPUK B-ORG\n) O\n. O\n\nDavies B-PER\nsaid O\nthe O\ntwo O\nleaders O\n\" O\nhave O\nagreed O\nto O\ncease O\nthe O\nfighting O\n( O\nand O\n) O\nreturn O\ntheir O\nforces O\nto O\nthe O\npositions O\nheld O\nbefore O\nthe O\ncurrent O\nfighting O\nbegan O\n\" O\non O\nAugust O\n17 O\n. O\n\nHe O\ndid O\nnot O\ngive O\na O\nspecific O\ntime O\nfor O\nthe O\nceasefire O\nbut O\nsaid O\nthe O\nUnited B-LOC\nStates I-LOC\nlooked O\nforward O\nto O\n\" O\nimmediate O\nimplementation O\n\" O\n. O\n\nThe O\ntwo O\nparty O\nleaders O\nhad O\nalso O\nagreed O\nto O\nmeet O\nU.S. B-LOC\nAssistant O\nSecretary O\nfor O\nNear B-MISC\nEastern I-MISC\nAffairs O\nRobert B-PER\nPelletreau I-PER\nin O\nSeptember O\n\" O\nto O\nsolidify O\nthe O\ncease-fire O\nand O\nto O\npursue O\nreconciliation O\n\" O\n, O\nDavies B-PER\nsaid O\n. O\n\nHis O\nstatement O\ngave O\nno O\nvenue O\nor O\nprecise O\ndate O\nfor O\nthe O\nmeeting O\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\nhas O\nalready O\ncalled O\non O\nthe O\nKurdish B-MISC\nfactions O\nto O\nhold O\npeace O\ntalks O\nin O\nLondon B-LOC\n. O\n\nThe O\nKDP B-ORG\nsaid O\nThursday O\nnight O\nit O\nhad O\nrepelled O\nan O\nattack O\nby O\nthousands O\nof O\nPUK B-ORG\nfighters O\n, O\nkilling O\n, O\nwounding O\nor O\ncapturing O\nabout O\n400 O\nopposing O\nguerrillas O\n. O\n\nThe O\nfighting O\nhas O\nthreatened O\na O\nU.S.-led B-MISC\npeace O\nplan O\nto O\nunite O\nthe O\nmountainous O\nKurdish B-MISC\nregion O\nin O\nnorthern O\nIraq B-LOC\nagainst O\nPresident O\nSaddam B-PER\nHussein I-PER\n. O\n\n-DOCSTART- O\n\nOne O\nteen O\nleft O\ndead O\nby O\nattack O\non O\nU.S. B-LOC\nslumber O\nparty O\n. O\n\nCHESAPEAKE B-LOC\n, O\nVa B-LOC\n. O\n\n1996-08-23 O\n\nA O\nknife-wielding O\nneighbour O\napparently O\nintent O\non O\nsexual O\nassault O\ninvaded O\na O\nteenage O\nslumber O\nparty O\non O\nFriday O\n, O\nkilling O\none O\ngirl O\nand O\nwounding O\nthree O\nothers O\n, O\npolice O\nsaid O\n. O\n\nAt O\nabout O\n4 O\na.m. O\nEDT O\n( O\n0800 O\nGMT B-MISC\n) O\n, O\na O\ngroup O\nof O\nteenaged O\ngirls O\nwere O\nhaving O\nthe O\novernight O\nparty O\nin O\nthe O\nCamelot B-LOC\nsubdivision O\nof O\nthis O\neastern O\nVirginia B-LOC\ncity O\n, O\nwhen O\na O\nman O\nentered O\nthe O\nhouse O\n, O\nwielding O\na O\nknife O\n, O\nthreatening O\nto O\nsexually O\nassault O\nthe O\ngirls O\n. O\n\nDetective O\nRichard B-PER\nBlack I-PER\nof O\nthe O\nChesapeake B-ORG\nPolice I-ORG\nDepartment I-ORG\n, O\nsaid O\na O\nneighbour O\n, O\nCurtis B-PER\nLee I-PER\nWhite I-PER\nII I-PER\n, O\n19 O\n, O\nwas O\narrested O\nin O\nthe O\nattack O\n, O\nbut O\nhad O\nnot O\nbeen O\ncharged O\nby O\nlate O\nmorning O\non O\nFriday O\n. O\n\nThere O\nwere O\napparently O\nno O\nadults O\nat O\nthe O\nparty O\nas O\nthe O\nfather O\nof O\nthe O\nfamily O\nwho O\nlived O\nin O\nthe O\nhouse O\nwas O\nout O\nof O\ntown O\nand O\nthe O\nmother O\ndied O\nmore O\nthan O\na O\nyear O\nago O\n, O\nBlack B-PER\nsaid O\n. O\n\nThe O\ndetective O\nsaid O\ndetails O\nwere O\nsketchy O\n, O\nbut O\ntwo O\nof O\nthe O\nteenagers O\nwere O\nreportedly O\ndownstairs O\nwatching O\ntelevision O\nwhen O\nWhite B-PER\nallegedly O\nentered O\nthe O\nhouse O\nand O\ntold O\nthe O\ngirls O\nto O\ntake O\noff O\ntheir O\nclothes O\n. O\n\nHe O\nsaid O\na O\nmale O\nteenager O\nsleeping O\nupstairs O\nreportedly O\nheard O\nthe O\ncommotion O\nand O\ncame O\ndownstairs O\nand O\nconfronted O\nWhite B-PER\n, O\nwho O\nallegedly O\nstabbed O\nhim O\nmore O\nthan O\nonce O\n. O\n\nThe O\nother O\nteenagers O\nalso O\nconfronted O\nthe O\nassailant O\nand O\nthree O\ngirls O\n, O\nall O\nunder O\n18 O\n, O\nwere O\nstabbed O\n, O\none O\nfatally O\n. O\n\n\" O\nAt O\nleast O\ntwo O\nof O\nthem O\nwere O\nsexually O\nmolested O\n, O\n\" O\nBlack B-PER\nsaid O\n. O\n\nHe O\nsaid O\nall O\nof O\nthe O\nwounded O\nteenagers O\nwere O\ntaken O\nto O\na O\nhospital O\nbut O\nnone O\nof O\nthe O\ninjuries O\nwere O\nconsidered O\nlife-threatening O\n. O\n\nPolice O\nsaid O\nthe O\ngirl O\nwho O\ndied O\nwas O\nidentified O\nas O\nMichelle B-PER\nHarper I-PER\n. O\n\nHer O\nage O\nwas O\nnot O\ngiven O\n. O\n\n-DOCSTART- O\n\nGlickman B-PER\nsays O\nUSDA B-ORG\nmonitoring O\naflatoxin O\nin O\nTexas B-LOC\n. O\n\nWASHINGTON B-LOC\n1996-08-23 O\n\nAgriculture O\nSecretary O\nDan B-PER\nGlickman I-PER\nsaid O\nthe O\ndepartment O\nwas O\nmonitoring O\nreports O\nof O\naflatoxin O\nfound O\nin O\ncorn O\nin O\nparts O\nof O\nTexas B-LOC\n. O\n\n\" O\nWe O\n're O\nalways O\nconcerned O\nabout O\naflatoxin O\nbut O\nwe O\n're O\non O\ntop O\nof O\nit O\n, O\n\" O\nGlickman B-PER\ntold O\nreporters O\nafter O\naddressing O\na O\nUSDA-sponsored B-MISC\nfarmers O\n' O\nmarket O\n. O\n\n\" O\nThat O\n's O\na O\nperennial O\nproblem O\n. O\n\nIt O\nmay O\nbe O\na O\nlittle O\nmore O\nproblematic O\nbecause O\nof O\ncold O\n, O\nwet O\nconditions O\nbut O\nwe O\n're O\non O\ntop O\nof O\nit O\n, O\n\" O\nthe O\nsecretary O\nsaid O\n. O\n\nAsked O\nabout O\nreports O\nEgypt B-LOC\nhas O\nset O\nnew O\nlevels O\nfor O\na O\nvomitoxin O\nin O\nits O\npurchase O\nof O\nU.S. B-LOC\nwheat O\n, O\nthe O\nsecretary O\nsaid O\n\" O\nI O\ndo O\nn't O\nknow O\nanything O\nabout O\nit O\n\" O\nbut O\nadded O\nthat O\nUSDA B-ORG\nofficials O\nwere O\n\" O\nlooking O\nat O\nit O\n. O\n\" O\n\n-DOCSTART- O\n\nMass B-LOC\n. O\n\ngovernor O\nhas O\ntrouble O\nwinning O\nhome O\nsupport O\n. O\n\nBOSTON B-LOC\n1996-08-23 O\n\nThe O\n12-year-old O\ndaughter O\nof O\nRepublican B-MISC\nGov O\n. O\n\nWilliam B-PER\nWeld I-PER\nis O\nworking O\nto O\nstop O\nhis O\nbid O\nto O\nwin O\na O\nU.S. B-LOC\nSenate B-ORG\nseat O\nbecause O\nshe O\ndoes O\nn't O\nwant O\nto O\nleave O\nMassachusetts B-LOC\n. O\n\nWeld B-PER\nconceded O\nhis O\n12-year-old O\ndaughter O\n, O\nFranny B-PER\n, O\nis O\n\" O\na O\nfoot O\nsoldier O\n\" O\nfor O\nDemocratic B-MISC\nincumbent O\nSen O\n. O\n\nJohn B-PER\nKerry I-PER\n, O\neven O\nthough O\nshe O\nis O\nn't O\nold O\nenough O\nto O\nvote O\n. O\n\nWeld B-PER\n, O\nspeaking O\non O\nWBUR-FM B-ORG\nradio O\non O\nThursday O\n, O\nsaid O\nhe O\nwas O\nfacing O\na O\nrevolt O\nfrom O\nhis O\ndaughter O\nin O\npart O\nbecause O\nshe O\ndoes O\nnot O\nwant O\nto O\nleave O\nCambridge B-LOC\n, O\nMassachusetts B-LOC\n, O\nand O\nmove O\nto O\nWashington B-LOC\n. O\n\nHe O\nalso O\nsaid O\nFranny B-PER\nWeld I-PER\n's O\nbest O\nfriend O\n, O\nTracy B-PER\nRoosevelt I-PER\n, O\nmight O\nhave O\nsomething O\nto O\ndo O\nwith O\nher O\npolitics O\n. O\n\nTracy B-PER\nis O\nthe O\ngreat-granddaughter O\nof O\nDemocratic B-MISC\nformer O\nPresident O\nFranklin B-LOC\nRoosevelt I-LOC\n, O\nand O\nsupport O\nfor O\nDemocrats B-MISC\nruns O\nin O\nthe O\nfamily O\n. O\n\nThe O\nRoosevelts B-PER\nare O\ngood O\nfriends O\nof O\nWeld B-PER\nand O\nhis O\nwife O\n, O\nSusan B-PER\nRoosevelt I-PER\nWeld I-PER\n, O\na O\ndescendant O\nof O\nformer O\nPresident O\nTheodore B-PER\nRoosevelt I-PER\n, O\nwho O\nwon O\nthe O\npresidency O\nas O\na O\nRepublican B-MISC\n. O\n\n-DOCSTART- O\n\nLufthansa B-ORG\ncargo O\nQ2 O\nload O\nfactor O\nup O\n1.7 O\npct O\n. O\n\nFRANKFURT B-LOC\n1996-08-23 O\n\nThe O\nfollowing O\ntable O\nshows O\nLufthansa B-ORG\nCargo I-ORG\nAG I-ORG\nsecond O\nquarter O\n1996 O\nresults O\n, O\nbased O\non O\nfigures O\npublished O\nby O\nDeutsche B-ORG\nLufthansa I-ORG\nAG I-ORG\nin-house O\nnewspaper O\n\nLufthanseat B-ORG\n. O\n\nAvailable O\nfreight-tonne O\nkilometres O\n( O\nmillion O\n) O\n2,389 O\nup O\n4 O\npct O\n\nRevenue O\nfreight-tonne O\nkilometres O\n( O\nmillion O\n) O\n1,600 O\nup O\n7 O\npct O\n\nFreight O\nload O\nfactor O\n67.0 O\nup O\n1.7 O\npct O\npts O\n\nRevenue O\nfrom O\ntransport O\n( O\nDm B-MISC\nmillion O\n) O\n820 O\nup O\n2 O\npct O\n\nRevenue O\nfrom O\nother O\nservices O\n( O\nDm B-MISC\nmillion O\n) O\n14 O\ndown O\n26 O\npct O\n\nStaff O\ncosts O\n( O\nDm B-MISC\nmillion O\n) O\n116 O\nup O\n8 O\npct O\n\nFuel O\ncosts O\n( O\nDm B-MISC\nmillion O\n) O\n69 O\nup O\n20 O\npct O\n\nFlight-related O\nfees O\n( O\nDm B-MISC\nmillion O\n) O\n125 O\nup O\n17 O\npct O\n\n- O\nAir B-ORG\nCargo I-ORG\nNewsroom I-ORG\nTel+44 O\n171 O\n542 O\n7706 O\nFax+44 O\n171 O\n542 O\n5017 O\n\n-DOCSTART- O\n\nWSC-India B-ORG\nRice O\nWeather O\n, O\nAug O\n23 O\n. O\n\nSUMMARY- O\nShowers O\n0.25-1.30 O\ninch O\n( O\n6-33 O\nmm O\n) O\nand O\nlocally O\nheavier O\nthrough O\nmuch O\nof O\nIndia B-LOC\n, O\n75 O\npercent O\ncoverage O\n. O\n\nIsolated O\nshowers O\n0.20-0.70 O\ninch O\n( O\n5-18 O\nmm O\n) O\nin O\nthe O\nnorth O\n. O\n\nHighs O\n82-96F O\n( O\n28-36C O\n) O\n. O\n\nCROP O\nIMPACT- O\nConditions O\nremain O\nfavorable O\nfor O\nthe O\ndevelopment O\nof O\nrice O\nin O\nthe O\nregion O\n. O\n\nFORECAST- O\n\nTODAY O\n... O\n\nShowers O\nand O\nrain O\n0.25-1.00 O\ninch O\n( O\n6-25 O\nmm O\n) O\nand O\nlocally O\nheavier O\nthrough O\nmost O\nof O\ncentral O\nand O\nsouth O\ncentral O\nIndia B-LOC\n, O\nup O\nto O\n0.75 O\ninch O\n( O\n19 O\nmm O\n) O\nin O\n75 O\npercent O\nof O\nnorth O\ncentral O\nIndia B-LOC\n, O\nand O\nonly O\nisolated O\nup O\nto O\n0.50 O\ninch O\n( O\n13 O\nmm O\n) O\nelsewhere O\nover O\nIndia B-LOC\n. O\n\nHighs O\n82-96F O\n( O\n28-36C O\n) O\n. O\n\nTONIGHT O\n... O\n\nVariable O\nclouds O\nin O\nsouthern O\nIndia B-LOC\nwith O\nshowers O\n. O\n\nPartly O\ncloudy O\nin O\nnorthern O\nIndia B-LOC\nwith O\na O\nfew O\nlight O\nshowers O\n. O\n\nLows O\n68-76F O\n( O\n20-24C O\n) O\n. O\n\nTOMORROW O\n... O\n\nLittle B-PER\nchange O\nfrom O\ntoday O\n's O\nweather O\nexpected O\n. O\n\nOUTLOOK O\n... O\n\nNumerous O\nto O\nscattered O\nshowers O\nand O\nthunderstorms O\nin O\nsouthern O\nand O\ncentral O\nIndia B-LOC\n, O\nand O\nisolated O\nshowers O\nto O\nthe O\nnorth O\nSunday O\nthrough O\nTuesday O\n. O\n\nTemperatures O\nnear O\nnormal O\n. O\n\nSource O\n: O\nWeather B-ORG\nServices I-ORG\nCorporation I-ORG\n\n-DOCSTART- O\n\nWashington B-LOC\nto O\ncurb O\nTamil B-MISC\nsupport O\nin O\nU.S. B-LOC\n- O\nSri B-LOC\nLanka I-LOC\n. O\n\nCOLOMBO B-LOC\n1996-08-23 O\n\nSri B-LOC\nLanka I-LOC\nsaid O\non O\nFriday O\nthe O\nUnited B-LOC\nStates I-LOC\nhad O\npromised O\nto O\nstamp O\nout O\nany O\nillegal O\nactivities O\non O\nU.S. B-LOC\nsoil O\ndirected O\nagainst O\nthe O\nisland O\n's O\ngovernment O\n. O\n\nThe O\nSri B-MISC\nLankan I-MISC\nforeign O\nministry O\nsaid O\nin O\na O\nstatement O\n: O\n\" O\nThe O\nUnited B-LOC\nStates I-LOC\ngovernment O\nsympathised O\nwith O\nthe O\ncurrent O\npredicament O\nSri B-LOC\nLanka I-LOC\nwas O\nfacing O\n. O\n\" O\n\nThe O\nstatement O\nsaid O\nthe O\nU.S. B-LOC\ngovernment O\n\" O\nwould O\ndo O\nall O\nwithin O\nits O\nprevailing O\nlegal O\nframework O\nto O\nprevent O\nthe O\nuse O\nof O\nAmerican B-MISC\nsoil O\nto O\nperpetrate O\nviolence O\nagainst O\nthe O\ndemocratic O\ngovernment O\nof O\nSri B-LOC\nLanka I-LOC\n\" O\n. O\n\nIt O\nsaid O\nthe O\nU.S. B-ORG\nState I-ORG\nDepartment I-ORG\n's O\ncoordinator O\nfor O\ncounter O\nterrorism O\n, O\nPhilip B-PER\nWilcox I-PER\n, O\nhad O\nexpressed O\nWashington B-LOC\n's O\nsupport O\nfor O\nthe O\ngovernment O\nwhen O\nhe O\nvisited O\nColombo B-LOC\nthis O\nweek O\n. O\n\nColombo B-LOC\nhas O\nsaid O\nit O\nbelieves O\nTamil B-MISC\nrebels O\n, O\nfighting O\na O\n13-year O\nwar O\nfor O\nindependence O\nagainst O\nthe O\ngovernment O\n, O\nfinance O\ntheir O\nmilitary O\nactivity O\nthrough O\nfunds O\nextorted O\nfrom O\nexpatriate O\nSri B-MISC\nLankans I-MISC\nin O\nwestern O\ncountries O\nsuch O\nas O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\nU.S. B-LOC\nembassy O\nofficials O\nin O\nColombo B-LOC\nwere O\nnot O\nimmediately O\navailable O\nto O\ncomment O\non O\nthe O\nreport O\n. O\n\nColombo B-LOC\nestimates O\nmore O\nthan O\n50,000 O\npeople O\nhave O\nbeen O\nkilled O\nin O\nthe O\nwar O\nbetween O\ngovernment O\nforces O\nand O\nthe O\nLiberation B-ORG\nTigers I-ORG\nof I-ORG\nTamil I-ORG\nEelam I-ORG\nrebels O\nin O\nthe O\nisland O\n's O\nnorth O\nand O\neast O\n. O\n\n-DOCSTART- O\n\nNepal B-LOC\n's O\nking O\nleaves O\non O\nweek-long O\nvisit O\nto O\nChina B-LOC\n. O\n\nKATHMANDU B-LOC\n1996-08-23 O\n\nKing O\nBirendra B-PER\nleft O\nNepal B-LOC\non O\nFriday O\nfor O\na O\nweek-long O\nvisit O\nto O\nChina B-LOC\n, O\nhis O\neighth O\nsince O\nascending O\nthe O\nthrone O\nin O\n1972 O\n, O\nofficials O\nsaid O\n. O\n\nThe O\nconstitutional O\nmonarch O\n, O\nwho O\nlast O\nvisited O\nChina B-LOC\nin O\n1993 O\n, O\nwas O\nscheduled O\nto O\nmeet O\nChinese B-MISC\nPresident O\nJiang B-PER\nZemin I-PER\nand O\nPremier O\nLi B-PER\nPeng I-PER\nduring O\nhis O\nvisit O\n, O\nthey O\nsaid O\n. O\n\nForeign O\nministry O\nofficials O\ngave O\nno O\ndetails O\nof O\nthe O\nissues O\nthe O\nking O\n, O\nwho O\nwas O\naccompanied O\nby O\nForeign O\nMinister O\nPrakash B-PER\nChandra I-PER\nLohani I-PER\n, O\nwould O\ndiscuss O\nwith O\nChinese B-MISC\nleaders O\n. O\n\nThe O\nHimalayan B-MISC\nkingdom O\n, O\nsandwiched O\nbetween O\nChina B-LOC\nand O\nIndia B-LOC\n, O\nhas O\ntraditionally O\nsought O\nto O\nmaintain O\nclose O\ncooperation O\nwith O\nits O\ngiant O\nneighbours O\n, O\nand O\nan O\nequal O\ndistance O\nfrom O\nthe O\ntwo O\n. O\n\nThe O\n50-year O\nold O\nmonarch O\nwas O\naccompanied O\nby O\nQueen O\nAishwarya B-PER\non O\na O\nflight O\nto O\nthe O\nTibetan B-MISC\ncapital O\nof O\nLhasa B-LOC\n. O\n\nThe O\nking O\nwill O\nvisit O\nChongqing B-LOC\nbefore O\narriving O\nin O\nthe O\nChinese B-MISC\ncapital O\n, O\nBeijing B-LOC\n, O\nearly O\nnext O\nweek O\n, O\nofficials O\nsaid O\n. O\n\n-DOCSTART- O\n\nNepal B-LOC\nman O\nheld O\nfor O\nkeeping O\nchild O\nservant O\nin O\nchains O\n. O\n\nKATHMANDU B-LOC\n1996-08-23 O\n\nNepali B-MISC\npolice O\nsaid O\non O\nFriday O\nthey O\narrested O\na O\nman O\nwho O\nallegedly O\nkept O\na O\nchild O\nservant O\nbound O\nin O\nchains O\nso O\nthat O\nhe O\nwould O\nnot O\nrun O\naway O\nwhen O\nhis O\nemployer O\nwas O\nout O\nto O\nwork O\n. O\n\nMadhusudan B-PER\nMunakarmi I-PER\nwas O\narrested O\non O\nThursday O\nafter O\nhis O\nneighbours O\ninformed O\npolice O\nabout O\nthe O\nplight O\nof O\n12-year O\nold O\nDhiraj B-PER\nK.C. I-PER\n, O\nwho O\ntold O\npolice O\nhis O\nemployer O\nused O\nto O\ntie O\nhim O\nup O\nwith O\niron O\nchains O\nand O\nlocks O\nconcealed O\nunder O\nhis O\nclothes O\n. O\n\nThe O\nneighbours O\nin O\nKathmandu B-LOC\ncalled O\nthe O\npolice O\nwhen O\nthey O\nsaw O\nDheeraj B-PER\n, O\nemployed O\nby O\nthe O\nman O\nfor O\nthe O\npast O\nnine O\nmonths O\n, O\nlimping O\nbecause O\nof O\nthe O\nchains O\n. O\n\n\" O\nI O\nfeared O\nhe O\nwould O\nflee O\nfrom O\nwork O\nor O\nsteal O\nmy O\nbelongings O\n, O\n\" O\nthe O\nKathmandu B-ORG\nPost I-ORG\nnewspaper O\nquoted O\nMunakarmi B-PER\nas O\nsaying O\nafter O\nhis O\narrest O\n. O\n\nIf O\nconvicted O\n, O\nhe O\nfaces O\na O\nmaximum O\nof O\nthree O\nyears O\nin O\njail O\nunder O\nNepal B-LOC\n's O\nchild O\nprotection O\nlaws O\n. O\n\n-DOCSTART- O\n\nOPTIONS O\n- O\nEuro B-MISC\ndebt O\nvols O\nseen O\nregrouping O\nafter O\nfall O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nImplied O\nvolatility O\nof O\nEuropean B-MISC\nbond O\nand O\ninterest O\nrate O\noptions O\nshould O\nstabilise O\naround O\ncurrent O\nlevels O\nuntil O\nearly O\nnext O\nweek O\nafter O\nfalling O\nbefore O\nand O\nafter O\nthis O\nweek O\n's O\nGerman-led B-MISC\ncut O\nin O\ninterest O\nrates O\n, O\ntraders O\nsaid O\n. O\n\n\" O\nVolatility O\nhas O\ncome O\noff O\na O\nlot O\n. O\n\nWe O\n're O\nlooking O\nfor O\nit O\nto O\nstabilise O\nnow O\n, O\n\" O\nsaid O\none O\nEuromark B-MISC\noptions O\ntrader O\nat O\na O\nU.S. B-LOC\nbank O\n. O\n\nA O\ntrader O\nat O\na O\nJapanese B-MISC\nbank O\nsaid O\nEuromark B-MISC\nvolatility O\nnow O\nstood O\nat O\n14.00 O\nfor O\nSeptember O\ncontract O\n, O\n16.75 O\nfor O\nDecember O\n, O\n19.50 O\nfor O\nMarch O\nand O\n21.25 O\nfor O\nJune O\n. O\n\nThis O\ncompared O\nwith O\nmidweek O\nlevels O\n, O\nbefore O\nthe O\nwelter O\nof O\ninterest O\nrate O\ncuts O\n, O\nof O\n18.50 O\nfor O\nSeptember O\n, O\n20.00 O\nfor O\nDecember O\n, O\n22.00 O\nfor O\nMarch O\nand O\n23.5 O\nfor O\nJune O\n, O\nhe O\nsaid O\n. O\n\nAt O\n1347 O\nGMT B-MISC\n, O\nDecember O\nEuromark B-MISC\nfutures O\nwere O\ntrading O\nat O\n96.78 O\n, O\ntwo O\nbasis O\npoints O\ndown O\non O\nthe O\nday O\n. O\n\nHe O\nsaid O\nthe O\nsell-off O\nin O\nJune O\nvols O\nmight O\nhave O\nbeen O\noverdone O\n, O\nwhich O\ncould O\noffer O\nvalue O\nat O\ncurrent O\nlevels O\n. O\n\nHe O\nsaid O\ncaps O\nand O\nfloors O\nwould O\nbe O\nwell O\nbid O\nafter O\nthe O\nround O\nof O\ninterest O\nrate O\ncuts O\ndue O\nto O\nthe O\nfact O\nthese O\nrates O\nshould O\nstay O\nlow O\nat O\nthe O\nshort O\nend O\n. O\n\nThe O\nsize O\nof O\nthe O\nBundesbank B-ORG\n's O\nrepo O\nrate O\ncut O\n, O\nto O\n3.00 O\npercent O\nfrom O\n3.30 O\npercent O\n, O\ntook O\nmarkets O\nby O\nsurprise O\n. O\n\n\" O\nVolatility O\nhas O\na O\nbid O\nto O\nit O\n-- O\nlonger-dated O\nvolatility O\nmore O\nthan O\nshort-dated O\nbecause O\nthe O\nevent O\npeople O\nwere O\nbuying O\nfor O\nhas O\npassed O\nand O\nnow O\nperhaps O\npeople O\nwill O\nsell O\nsome O\nshort O\ndated O\nvol O\nand O\nbuy O\nsome O\nlong O\ndated O\nvol O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nLong O\ndated O\nvolatility O\nhas O\nbeen O\nlow O\nthis O\nyear O\n, O\nso O\nit O\nis O\nstill O\nat O\nlevels O\nwhich O\nare O\nnot O\nhistorically O\nhigh O\n. O\n\n\" O\nIt O\nis O\nnot O\na O\ndangerous O\nlevel O\nto O\nown O\nvol. O\nYou O\nare O\nnot O\ngoing O\nto O\nlose O\na O\nlot O\nand O\nyou O\ncould O\nmake O\nquite O\na O\nbit O\n. O\n\" O\n\nHe O\nsaid O\nvolatility O\nlevels O\nshould O\nbe O\nstable O\nuntil O\nmarkets O\nreassess O\nthe O\nsituation O\nafter O\na O\nlong O\nweekend O\nin O\nBritain B-LOC\n. O\n\nParibas B-ORG\nCapital I-ORG\nMarkets I-ORG\nOTC I-ORG\noptions O\nspecialist O\nRobert B-PER\nCoughlan I-PER\nsaid O\nthat O\nif O\nvolatility O\ncontinued O\nlower O\nfor O\nthe O\nrest O\nof O\nFriday O\nin O\nover-the-counter O\n10-year O\nBunds B-MISC\n, O\nit O\nshould O\nbe O\nhigher O\nnext O\nTuesday O\n. O\n\nHe O\nsaid O\nthe O\nabsence O\non O\nholiday O\nof O\nmany O\nmarket O\nmakers O\nwas O\na O\nmain O\nfactor O\nbehind O\nfalls O\nthis O\nweek O\nin O\nvolatility O\nin O\nhigh-yielding O\nmarkets O\nsuch O\nas O\nItaly B-LOC\n, O\nSpain B-LOC\nand O\nSweden B-LOC\n. O\n\nCoughlan B-PER\nsaid O\nthe O\nmarket O\nhad O\nmore O\ndownside O\nthan O\nupside O\npotential O\n, O\nbut O\na O\nfall O\nwas O\nnot O\nlikely O\nto O\nbe O\nof O\nsignificant O\nsize O\n. O\n\n\" O\nI O\nrecommend O\npeople O\nsell O\nstrangles O\nin O\na O\nnumber O\nof O\nmarkets O\n-- O\nin O\nGermany B-LOC\nand O\nFrance B-LOC\nin O\nparticular O\n. O\n\n\" O\nWith O\nhigh-yielding O\nmarkets O\nItaly B-LOC\nwill O\nbe O\na O\nlot O\nmore O\nvulnerable O\nin O\nSeptember O\non O\neconomic O\nand O\npolitical O\nfronts O\n, O\nso O\nI O\nwould O\nuse O\ncurrent O\nthe O\nlow O\nlevel O\nof O\nvol O\nto O\nbuy O\noptions O\n. O\n\n\" O\nSo O\nsell O\noptions O\non O\nBunds B-MISC\nand O\nFrance B-LOC\nto O\nenhance O\nyield O\nand O\nbuy O\noptions O\non O\nItaly B-LOC\n, O\n\" O\nCoughlan B-PER\nsaid O\n.. O\n\n-- O\nStephen B-PER\nNisbet I-PER\n, O\nInternational B-ORG\nBonds I-ORG\n+44 O\n171 O\n542 O\n6320 O\n\n-DOCSTART- O\n\nGoldman B-ORG\nSachs I-ORG\nsets O\nwarrants O\non O\nContinental B-ORG\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nGoldman B-ORG\nSachs I-ORG\n& I-ORG\nCo I-ORG\nWertpapier I-ORG\nGmbH I-ORG\nhas O\nissued O\na O\ntotal O\nof O\nfive O\nmillion O\nAmerican-style B-MISC\ncall O\nwarrants O\n, O\non O\nContinental B-ORG\nAG I-ORG\n, O\nlead O\nmanager O\nGoldman B-ORG\nSachs I-ORG\n& I-ORG\nCo I-ORG\nsaid O\n. O\n\nOne O\nwarrant O\ncontrols O\none O\nshare O\n. O\n\nSTRIKE O\nPRICE O\n25.00 O\nDEM B-MISC\nPREMIUM O\n10.12 O\nPCT O\n\nISSUE O\nPRICE O\n2.42 O\nDEM B-MISC\nGEARING O\n10.29 O\nX O\n\nEXERCISE O\nPERIOD O\n02.SEP.96-21.NOV.97 O\nPAYDATE O\n30.AUG.96 O\n\nLISTING O\nDDF O\nFFT O\nSTG O\nMIN O\nEXER O\nLOT O\n100 O\n\nSPOT O\nREFERENCE O\n24.90 O\nDEM B-MISC\n\n-- O\nReuter B-ORG\nLondon I-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n7658 O\n\n-DOCSTART- O\n\nLegal O\nchallenge O\nto O\nDiana B-PER\ndelayed O\nby O\njail O\nterm O\n. O\n\nLONDON B-LOC\n1996-08-23 O\n\nA O\nBritish B-MISC\nphotographer O\nbranded O\na O\nstalker O\nby O\nPrincess O\nDiana B-PER\nhas O\nbeen O\nforced O\nto O\npostpone O\na O\nlegal O\nchallenge O\nto O\na O\nban O\non O\napproaching O\nher O\nbecause O\nhe O\n's O\nbeen O\njailed O\nfor O\ncriminal O\ndamage O\n, O\nhis O\nlawyer O\nsaid O\non O\nFriday O\n. O\n\nMartin B-PER\nStenning I-PER\nstarted O\na O\n12-week O\njail O\nsentence O\non O\nThursday O\njust O\nas O\nhe O\nwas O\npreparing O\nto O\ncontest O\nan O\ninjunction O\nobtained O\nby O\nDiana B-PER\nbanning O\nhim O\nfrom O\ncoming O\nwithin O\n300 O\nmetres O\n( O\nyards O\n) O\nof O\nher O\n. O\n\n\" O\nWe O\nwere O\nin O\nthe O\nprocess O\nof O\npreparing O\na O\ndetailed O\naffidavit O\nresponding O\nto O\nthe O\nPrincess O\n's O\naffadavit O\nand O\nexpected O\nto O\ngo O\nto O\ncourt O\nin O\nthe O\nnext O\ncouple O\nof O\nweeks O\n, O\n\" O\nsaid O\nStenning B-PER\n's O\nlawyer O\n, O\nBenedict B-PER\nBirnberg I-PER\n. O\n\" O\n\nBut O\neverything O\nhas O\nbeen O\nput O\non O\nice O\nnow O\n. O\n\" O\n\nBirnberg B-PER\ntold O\nReuters B-ORG\nthat O\nthe O\nchallenge O\nto O\nthe O\ninjunction O\nwould O\nbe O\ndelayed O\nuntil O\nStenning B-PER\nwas O\nreleased O\n. O\n\nStenning B-PER\nthrew O\na O\nbrick O\nthrough O\nthe O\nwindow O\nof O\na O\nvan O\nin O\nFebruary O\nafter O\nan O\nargument O\nwith O\na O\ndriver O\nwhen O\nhe O\nwas O\nworking O\nas O\na O\nmotorcycle O\ndispatch O\nrider O\n. O\n\nStenning B-PER\n, O\nwho O\nhas O\nprevious O\nconvictions O\n, O\nis O\nexpected O\nto O\nappeal O\nagainst O\nthe O\nsentence O\n. O\n\nMagistrates O\nalso O\nordered O\nhim O\nto O\npay O\ncompensation O\nof O\n182 O\npounds O\n( O\n$ O\n282 O\n) O\n. O\n\nThe O\nfreelance O\nphotographer O\nwas O\nbranded O\na O\nstalker O\nby O\nDiana B-PER\n, O\nwhose O\ndivorce O\nfrom O\nheir-to-the-throne O\nPrince O\nCharles B-PER\nis O\ndue O\nto O\nbecome O\nfinal O\nnext O\nweek O\n, O\nafter O\npersistently O\ntrailing O\nher O\non O\nhis O\nmotorcycle O\n. O\n\nIn O\nan O\naffidavit O\n, O\nthe O\nprincess O\nsaid O\nthat O\nin O\nchasing O\nher O\nStenning B-PER\nhad O\ngot O\nso O\nclose O\nthat O\nhe O\ntwice O\nsmashed O\ninto O\nher O\ncar O\nand O\npushed O\nher O\nwhen O\nshe O\ntried O\nto O\nremove O\nthe O\nfilm O\nfrom O\nhis O\ncamera O\n. O\n\nStenning B-PER\nhas O\nrejected O\nDiana B-PER\n's O\nclaims O\nand O\nsaid O\nhe O\nwas O\nbeing O\nmade O\na O\nscapegoat O\nto O\nscare O\noff O\npress O\nphotographers O\n. O\n\n-DOCSTART- O\n\nJordan B-LOC\nexpels O\nIraqi B-MISC\ndiplomat O\n. O\n\nAMMAN B-LOC\n1996-08-23 O\n\nJordan B-LOC\nhas O\nasked O\nan O\nIraqi B-MISC\ndiplomat O\nto O\nleave O\nthe O\nkingdom O\nfor O\ncarrying O\nout O\nduties O\nincompatible O\nwith O\ndiplomatic O\nnorms O\n, O\nan O\nofficial O\nsource O\nsaid O\non O\nFriday O\n. O\n\nThe O\nmove O\ncame O\nafter O\nAmman B-LOC\nblamed O\nIraq B-LOC\nand O\na O\npro-Baghdad B-MISC\nlocal O\npolitical O\nparty O\nfor O\nlast O\nweek O\n's O\nworst O\nunrest O\nin O\nseven O\nyears O\nafter O\na O\ngovernment O\ndecision O\nto O\ndouble O\nprices O\nof O\nbread O\n. O\n\nThe O\ngovernment O\ndeclined O\ncomment O\n. O\n\n\" O\nJordan B-LOC\nhas O\nasked O\nMr. O\nAdel B-PER\nIbrahim I-PER\n, O\nthe O\nIraqi B-MISC\nembassy O\n's O\npress O\nattache O\n, O\nto O\nleave O\nbecause O\nhe O\nwas O\ncarrying O\nout O\nduties O\nincompatible O\nwith O\ndiplomatic O\nnorms O\n, O\n\" O\nthe O\nsource O\ntold O\nReuters B-ORG\n. O\n\nHe O\nsaid O\nIbrahim B-PER\nwas O\nstill O\nin O\nAmman B-LOC\n. O\n\nThe O\nJordanian B-ORG\nArab I-ORG\nSocialist I-ORG\nBaath I-ORG\nParty I-ORG\nhas O\ndenied O\ninvolvement O\nin O\nunrest O\nwhich O\nit O\nblamed O\non O\ngovernment O\npolicies O\nand O\nrising O\neconomic O\nhardship O\n. O\n\nThe O\nriots O\n, O\nwhich O\nshook O\nJordan B-LOC\nfor O\ntwo O\ndays O\n, O\nbroke O\nout O\nafter O\nlast O\nFriday O\n's O\nmain O\nprayers O\nin O\nthe O\nsouthern O\ntown O\nof O\nKarak B-LOC\nand O\nspread O\nto O\nAmman B-LOC\n. O\n\n-DOCSTART- O\n\nKurd B-MISC\nrebels O\nto O\nfree O\nTurkish B-MISC\nsoldier O\nprisoners O\n. O\n\nDOHUK B-LOC\n, O\nIraq B-LOC\n1996-08-23 O\n\nTurkish B-MISC\nKurd I-MISC\nguerrillas O\nsaid O\non O\nFriday O\nthey O\nwould O\nfree O\nseven O\nTurkish B-MISC\nsoldiers O\nthey O\nhold O\nin O\nnorthern O\nIraq B-LOC\nunder O\na O\ntentative O\nIslamist B-MISC\npeace O\nbid O\n. O\n\n\" O\n...For O\nthe O\nsake O\nof O\nsafety O\nwe O\nare O\nasking O\nfor O\ntheir O\nfamily O\nmembers O\nor O\nthe O\nauthorities O\nto O\ncome O\nand O\npick O\nthem O\nup O\n, O\n\" O\nKurdistan B-ORG\nWorkers I-ORG\nParty I-ORG\n( O\nPKK B-ORG\n) O\ncentral O\ncommittee O\nmember O\nRiza B-PER\nAltun I-PER\ntold O\njournalists O\nnear O\nthe O\nIraqi B-MISC\ncity O\nof O\nDohuk B-LOC\n. O\n\nPKK B-ORG\nguerrillas O\nwould O\naccompany O\nthe O\nsoldiers O\n, O\ncaptured O\nlast O\nspring O\nin O\none O\nof O\nTurkey B-LOC\n's O\nfrequent O\ncross-border O\ndrives O\n, O\nuntil O\nthey O\ncould O\nbe O\nhanded O\nover O\n, O\nhe O\nsaid O\n. O\n\nTheir O\nrelease O\nhas O\nbeen O\nnegotiated O\nby O\nIslamist B-MISC\nwriter O\nIsmail B-PER\nNacar I-PER\nas O\npart O\nof O\na O\nwider O\neffort O\n, O\npartly O\nbacked O\nby O\nPrime O\nMinister O\nNecmettin B-PER\nErbakan I-PER\n, O\nto O\nfind O\na O\npolitical O\nsolution O\nto O\nTurkey B-LOC\n's O\nKurdish B-MISC\nproblem O\n. O\n\nErbakan B-PER\nhas O\nencouraged O\nNacar B-PER\n's O\nbid O\nbut O\nhas O\nruled O\nout O\ndirect O\ntalks O\nwith O\nthe O\nrebels O\n. O\n\nThe O\nPKK B-ORG\noften O\nuses O\nbases O\nin O\nnorthern O\nIraq B-LOC\nin O\nits O\nfight O\nfor O\nautonomy O\nor O\nindependence O\nin O\nsoutheast O\nTurkey B-LOC\n. O\n\nMore O\nthan O\n20,000 O\npeople O\nhave O\ndied O\nin O\n12 O\nyears O\nof O\nfighting O\nbetween O\nthe O\nguerrillas O\nand O\nTurkish B-MISC\nforces O\n. O\n\n-DOCSTART- O\n\nSOLIDERE B-ORG\nshares O\nmixed O\non O\nmarket O\n. O\n\nBEIRUT B-LOC\n1996-08-23 O\n\nSOLIDERE B-ORG\nshares O\nwere O\nmixed O\non O\nFriday O\non O\nthe O\nprivately-operated O\nBeirut B-ORG\nSecondary I-ORG\nMarket I-ORG\n( O\nBSM B-ORG\n) O\n. O\n\nA O\nshares O\n-- O\ndistributed O\nto O\nformer O\nholders O\nof O\nproperty O\nrights O\nin O\nthe O\nBeirut B-LOC\ncentral O\ndistrict O\nSOLIDERE B-ORG\nis O\nrebuilding O\n-- O\nclosed O\nat O\n$ O\n104.625 O\nunchanged O\nfrom O\nThursday O\n. O\n\nB O\nshares O\n-- O\nissued O\nin O\na O\n$ O\n650-million O\nsubscription O\nin O\nJanuary O\n1994 O\n-- O\nrose O\nto O\n$ O\n106.5 O\nfrom O\n$ O\n106.375 O\na O\nday O\nearlier O\n. O\n\nTurnover O\non O\nBSM B-ORG\n, O\nwhich O\ntrades O\nonly O\nSOLIDERE B-ORG\nshares O\n, O\nwas O\n8,049 O\nshares O\nfrom O\nThursday O\n's O\n8,757 O\nand O\nvalue O\nwas O\n$ O\n850,968 O\nfrom O\n$ O\n918,288 O\n. O\n\nOn O\nthe O\nofficial O\nBeirut B-ORG\nStock I-ORG\nExchange I-ORG\n, O\nonly O\n1,185 O\nCiments B-ORG\nLibanais I-ORG\nshares O\nwere O\ntraded O\nat O\n$ O\n1.1875 O\ncompared O\nwith O\n2,036 O\nshares O\ntraded O\non O\nThursday O\nat O\nthe O\nsame O\nprice O\n. O\n\nThere O\nwas O\nno O\ntrade O\nin O\nany O\nof O\nthe O\nthree O\nother O\nlisted O\ncompanies O\n: O\nCiments B-ORG\nBlancs I-ORG\n, O\nEternit B-ORG\nand O\nUniceramic B-ORG\n. O\n\nThe O\nBLOM B-MISC\nStock I-MISC\nIndex I-MISC\nwhich O\ncovers O\nboth O\nmarkets O\nrose O\n0.04 O\npercent O\nto O\n903.09 O\nand O\nthe O\nLISPI B-MISC\nindex O\nrose O\n0.02 O\npercent O\nto O\n81.58 O\n. O\n\n- O\nBeirut B-LOC\neditorial O\n( O\n961 O\n1 O\n) O\n864148 O\n353078 O\n861723 O\n\n-DOCSTART- O\n\nZenith B-ORG\nlands O\n$ O\n1 O\nbillion O\ncontract O\n, O\nplans O\n$ O\n100 O\nmillion O\nplant O\n. O\n\nSusan B-PER\nNadeau I-PER\n\nCHICAGO B-LOC\n1996-08-22 O\n\nA O\nconsortium O\nof O\ntelephone O\ncompanies O\nand O\nThe B-ORG\nWalt I-ORG\nDisney I-ORG\nCo I-ORG\n. O\n\nsaid O\nThursday O\nit O\nhad O\nsigned O\na O\n$ O\n1 O\nbillion O\ncontract O\nwith O\nZenith B-ORG\nto O\nmake O\ndigital O\ntelevison O\nset-top O\nboxes O\nfor O\nits O\nhome O\nentertainment O\nservice O\n. O\n\nThe O\nannouncement O\nof O\nthe O\ncontract O\nfor O\n3 O\nmillion O\nset-top O\nboxes O\ngave O\nnew O\nhope O\nto O\nZenith B-ORG\n, O\nwhich O\nhas O\nstruggled O\nwith O\nyears O\nof O\nlosses O\n. O\n\n\" O\nThis O\nreally O\nindicates O\nwe O\n're O\nback O\nin O\nthe O\nbusiness O\n, O\n\" O\nWilliam B-PER\nLuehrs I-PER\n, O\npresident O\nof O\nthe O\nGlenview B-LOC\n, O\nIll.-based B-MISC\ncompany O\n's O\nNetworks B-ORG\nServices I-ORG\nDivision I-ORG\n, O\nsaid O\nin O\na O\ntelephone O\ninterview O\n. O\n\" O\n\nAnytime O\nsomebody O\ngets O\nthe O\nopportunity O\nto O\nenter O\nthe O\nnext O\nera O\nwith O\nsuch O\na O\nbig O\nbang O\nhas O\ngot O\nto O\nbe O\nseen O\nas O\na O\nstrong O\nmessage O\nto O\nthe O\nindustry O\n. O\n\" O\n\nFollowing O\nthe O\nannouncement O\n, O\nZenith B-ORG\n's O\nstock O\nsoared O\n$ O\n5.50 O\nto O\n$ O\n16.875 O\non O\nthe O\nNew B-ORG\nYork I-ORG\nStock I-ORG\nExchange I-ORG\n. O\n\nThe O\nconsortium O\n, O\ncalled O\nAmericast B-ORG\n, O\nsaid O\nthe O\ncontract O\nwas O\npart O\nof O\nits O\nstrategy O\nto O\ndevelop O\nand O\nmarket O\nthe O\nnext O\ngeneration O\nin O\nhome O\nentertainment O\n. O\n\nIn O\naddition O\nto O\nDisney B-ORG\n, O\nAmericast B-ORG\n's O\npartners O\nare O\nphone O\ncompanies O\nAmeritech B-ORG\nCorp. I-ORG\n, O\nBellSouth B-ORG\nCorp. I-ORG\n, O\nGTE B-ORG\nCorp. I-ORG\nand O\nSBC B-ORG\nCommunications I-ORG\n. O\n\nAmericast B-ORG\nsaid O\nSouthern B-ORG\nNew I-ORG\nEngland I-ORG\nTelecommunications I-ORG\nCorp. I-ORG\nhas O\nsigned O\na O\nletter O\nof O\nintent O\nto O\njoin O\nthe O\ngroup O\n, O\nwhich O\nplans O\nto O\nprovide O\na O\nhome O\nentertainment O\nservice O\nsimilar O\nto O\ncable O\ntelevision O\n. O\n\nZenith B-ORG\nalso O\nsaid O\nit O\nplanned O\nto O\nbuild O\na O\nnew O\n$ O\n100 O\nmillion O\nplant O\nin O\nWoodridge B-LOC\n, O\nIll B-LOC\n. O\n\n, O\nto O\nmake O\npicture O\ntubes O\nfor O\n32- O\nand O\n35-inch O\nscreen O\nTV O\nsets O\n. O\n\nThe O\ncompany O\ncurrently O\nbuys O\nthe O\ntubes O\nfrom O\ncompetitors O\n. O\n\nThe O\nnew O\nplant O\n, O\nwhich O\nis O\ndependent O\non O\nobtaining O\nfinancing O\n, O\nwill O\ncreate O\nabout O\n280 O\nnew O\njobs O\n, O\nZenith B-ORG\nsaid O\n. O\n\nThe O\ncontract O\ncalls O\nfor O\nproduction O\nof O\nthe O\nset-top O\nboxes O\nover O\nfive O\nyears O\n. O\n\nLuehrs B-PER\nsaid O\nmanufacturing O\nwill O\nbegin O\nand O\nrevenue O\nwill O\nstart O\nto O\nroll O\nin O\nduring O\nthe O\nfirst O\nhalf O\nof O\nnext O\nyear O\n. O\n\nThe O\nboxes O\nwill O\nbe O\nmade O\non O\na O\nbuild-to-order O\nbasis O\n. O\n\nZenith B-ORG\nwill O\nconvert O\nits O\nChihuahua B-LOC\n, O\nMexico B-LOC\n, O\nanalogue O\nset-top O\nbox O\nplant O\nto O\nmanufacture O\nthe O\ndigital O\nboxes O\n. O\n\nLuehrs B-PER\ndeclined O\nto O\nsay O\nwhen O\nthe O\noperation O\nwas O\nexpected O\nto O\nbe O\nprofitable O\n. O\n\nAmericast B-ORG\nwill O\nprovide O\nthe O\nboxes O\nto O\nsubscribers O\nas O\npart O\nof O\nthe O\nservice O\n. O\n\nIts O\nservice O\nis O\nbeing O\nintroduced O\nin O\nselected O\nmarkets O\nacross O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\nLuehrs B-PER\nsaid O\ndigital O\ntechnology O\nin O\nset-top O\nboxes O\nis O\nonly O\nthe O\nbeginning O\nand O\nsaid O\nthe O\ntechnology O\nwill O\neventually O\nshow O\nup O\nin O\nretail O\nconsumer O\nelectronics O\n. O\n\n\" O\nWe O\n'll O\nbuild O\na O\nlot O\nof O\nthese O\ndevices O\ninto O\ntelevision O\nsets O\n, O\nfor O\ndigital O\ntelevision O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nAlthough O\nthat O\nis O\nnot O\nwhere O\nthis O\nparticular O\ncontract O\nis O\nheaded O\n, O\nthe O\nfact O\nthat O\nthere O\nis O\na O\nstrong O\nZenith B-ORG\npresence O\nwill O\npay O\nus O\ndividends O\nin O\nthe O\nfuture O\n. O\n\" O\n\nZenith B-ORG\nhas O\nbeen O\nplagued O\nby O\ngenerally O\nsoft O\nconditions O\nin O\nthe O\ncolour O\ntelevision O\nindustry O\n, O\nreporting O\nfull-year O\nlosses O\nsince O\n1989 O\n. O\n\nLast O\nmonth O\n, O\nit O\nreported O\na O\nsecond-quarter O\nloss O\nof O\n$ O\n33.2 O\nmillion O\n, O\nor O\n51 O\ncents O\na O\nshare O\n, O\nvs. O\na O\nloss O\nof O\n$ O\n45.3 O\nmillion O\n, O\nor O\n97 O\ncents O\na O\nshare O\n, O\na O\nyear O\nearlier O\n. O\n\nLast O\nNovember O\n, O\nSouth B-MISC\nKorea-based I-MISC\nLG B-ORG\nElectronics I-ORG\nInc. I-ORG\nbought O\na O\nmajority O\nstake O\nin O\nZenith B-ORG\n. O\n\nRobert B-PER\nGutenstein I-PER\n, O\nan O\nanalyst O\nfor O\nKalf B-ORG\n, I-ORG\nVoorhis I-ORG\n& I-ORG\nCo I-ORG\n. O\n\n, O\nsaid O\nthe O\ncontract O\nwas O\n\" O\nnot O\nunique O\n, O\nbut O\nit O\n's O\nbig O\n. O\n\" O\n\n\" O\nDigital O\nis O\ncoming O\n, O\nit O\n's O\neconomic O\nand O\nthe O\nquestion O\nis O\nwhat O\nwill O\nmake O\nthe O\nconsumer O\nhappy O\nand O\nat O\nwhat O\nprice O\n. O\n\" O\n\n-DOCSTART- O\n\nNatural B-ORG\nLaw I-ORG\nParty I-ORG\nsays O\nit O\ncan O\nmeditate O\nproblems O\naway O\n. O\n\nWASHINGTON B-LOC\n1996-08-22 O\n\nFrom O\nthe O\npeople O\nwho O\nbrought O\nyou O\nhundreds O\nof O\n\" O\nyogic O\nfliers O\n\" O\nwho O\nclaimed O\nto O\ndefy O\nnature O\nby O\nlevitating O\ncomes O\nThe B-ORG\nNatural I-ORG\nLaw I-ORG\nParty I-ORG\n, O\na O\nminor O\npolitical O\nparty O\nthat O\nnominated O\na O\npresidential O\ncandidate O\non O\nThursday O\n. O\n\nAt O\na O\nhotel O\nconvention O\nhere O\n, O\nthe O\nparty O\nassociated O\nwith O\nthe O\nTranscendental B-MISC\nMeditation I-MISC\n( O\nTM B-MISC\n) O\nmovement O\nnamed O\nphysicist O\nJohn B-PER\nHagelin I-PER\nas O\nits O\npresidential O\nnominee O\nfor O\nthe O\nNov. O\n5 O\nelection O\n. O\n\nThe O\nparty O\nis O\nrunning O\non O\na O\nplatform O\nclaiming O\nit O\ncan O\nward O\noff O\nproblems O\nbefore O\nthey O\noccur O\nthrough O\ntechniques O\nsuch O\nas O\nmass O\nmeditation O\nthat O\nwould O\nreduce O\nstress O\n, O\ncrime O\n, O\nterrorism O\nand O\neven O\nwars O\n. O\n\n\" O\nSocial O\nstress O\ncan O\nbe O\nreduced O\nand O\nproblems O\nsuch O\nas O\ncrime O\nand O\nviolence O\nwill O\nautomatically O\ndecrease O\n, O\n\" O\nsaid O\na O\nparty O\npaper O\n. O\n\nMany O\nparty O\nmembers O\nare O\npractitioners O\nof O\nTM B-MISC\n, O\nwhich O\ninvolves O\nmeditating O\nto O\na O\nrepeated O\nword O\nor O\nphrase O\n, O\ncalled O\na O\nmantra O\n. O\n\nSome O\nadvanced O\nTM B-MISC\nfollowers O\ncontend O\nthey O\ncan O\nactually O\nmediate O\nto O\nsuch O\na O\npoint O\nthat O\nthey O\nfly O\n. O\n\nBut O\nin O\na O\ndemonstration O\nof O\n\" O\nyogic O\nflying O\n\" O\nseveral O\nyears O\nago O\n, O\ncritics O\nsaid O\nthe O\npeople O\nwere O\nmerely O\nbouncing O\noff O\nthe O\nground O\nfrom O\na O\nsitting O\nposition O\n. O\n\n-DOCSTART- O\n\nHuge O\nWindows B-MISC\n95 I-MISC\nsales O\nfail O\nto O\nmeet O\nexpectations O\n. O\n\nMartin B-PER\nWolk I-PER\n\nSEATTLE B-LOC\n1996-08-22 O\n\nA O\nyear O\nafter O\nits O\nmassively O\npublicized O\nintroduction O\n, O\nMicrosoft B-ORG\nCorp. I-ORG\n's O\nWindows B-MISC\n95 I-MISC\ncomputer O\noperating O\nsystem O\nhas O\nfallen O\nshort O\nof O\nthe O\nmost O\noptimistic O\nexpectations O\nfor O\nthe O\nsoftware O\ngiant O\nand O\nthe O\nindustry O\n. O\n\nEven O\nthough O\nmore O\nthan O\n40 O\nmillion O\ncopies O\nof O\nWindows B-MISC\n95 I-MISC\nhave O\nbeen O\nsold O\n, O\nmaking O\nit O\nthe O\nfastest-selling O\nnew O\nsoftware O\never O\n, O\nit O\nwould O\nhave O\nbeen O\nimpossible O\nfor O\nany O\nproduct O\nto O\nlive O\nup O\nto O\nthe O\nunprecedented O\nhype O\nof O\nthe O\nAug. O\n24 O\n, O\n1995 O\nlaunch O\n, O\nwhen O\nstores O\naround O\nthe O\nworld O\nopened O\nat O\nmidnight O\nto O\ngreet O\nlong O\nlines O\nof O\ncustomers O\n. O\n\nThe O\nRedmond B-PER\n, O\nWash.-based B-MISC\ncompany O\nspent O\ntens O\nof O\nmillions O\nof O\ndollars O\npromoting O\nthe O\nproduct O\nwith O\nstunts O\nthat O\nincluded O\nbuying O\nthe O\nentire O\nprint O\nrun O\nof O\nthe O\nTimes B-ORG\nof I-ORG\nLondon I-ORG\nand O\nlighting O\nNew B-LOC\nYork I-LOC\n's O\nEmpire B-LOC\nState I-LOC\nbuilding O\nin O\na O\nWindows B-MISC\ncolor O\nscheme O\n. O\n\nBut O\nthe O\nproduct O\n, O\ndelivered O\neight O\nmonths O\nlate O\n, O\nhas O\nfallen O\nshort O\nof O\nits O\nsales O\npotential O\nin O\npart O\nbecause O\nMicrosoft B-ORG\ndelivered O\na O\nmixed O\nmessage O\nto O\nbusiness O\ncustomers O\n, O\nanalysts O\nsaid O\n. O\n\n\" O\nIt O\ndid O\nn't O\ndo O\nas O\nwell O\nas O\nit O\ncould O\nhave O\n, O\n\" O\nsaid O\nRob B-PER\nEnderle I-PER\n, O\nan O\nanalyst O\nwith O\nGiga B-ORG\nInformation I-ORG\nGroup I-ORG\n. O\n\nScores O\nof O\nsoftware O\nand O\nhardware O\ncompanies O\nthat O\nhad O\nhoped O\nfor O\na O\nbig O\nboost O\nin O\nsales O\nwere O\ndisappointed O\nwhen O\nonly O\na O\nbrief O\nspike O\nmaterialized O\n. O\n\n\" O\nPeople O\nwho O\nwere O\nexpecting O\nmajor O\ncoat-tails O\nwere O\nsomewhat O\ndisappointed O\n, O\n\" O\nsaid O\nScott B-PER\nWinkler I-PER\n, O\nan O\nanalyst O\nwith O\nGartner B-ORG\nGroup I-ORG\n. O\n\n\" O\nIt O\n's O\nnot O\nas O\nthough O\nit O\nhas O\nn't O\nhad O\nan O\nimpact O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nIt O\njust O\nhas O\nn't O\nhad O\nthe O\nhuge O\nearth-shattering O\nimpact O\nsome O\npeople O\nwere O\nlooking O\nfor O\n. O\n\" O\n\nSymantec B-ORG\nCorp. I-ORG\n, O\nwhich O\nhad O\nbeen O\namong O\nthe O\nmost O\nbullish O\nof O\nsoftware O\ncompanies O\nat O\nthe O\ntime O\nof O\nthe O\nWindows B-MISC\n95 I-MISC\nlaunch O\n, O\nended O\nup O\nposting O\ndisappointing O\nfinancial O\nresults O\nwhen O\nretail O\nsales O\nof O\nthe O\noperating O\nsystem O\nfell O\nshort O\nof O\nits O\nprojections O\n. O\n\nTouchstone B-ORG\nSoftware I-ORG\nCorp. I-ORG\nhad O\nto O\npay O\n$ O\n1.3 O\nmillion O\nin O\ncash O\nand O\nstock O\nto O\nsettle O\na O\nshareholders O\nlawsuit O\nbrought O\nafter O\nthe O\ncompany O\n's O\nsales O\nfailed O\nto O\nmeet O\nexpectations O\ntied O\nto O\nthe O\nWindows B-MISC\n95 I-MISC\nlaunch O\n. O\n\nMany O\nsoftware O\ndevelopers O\napparently O\nsaw O\ntheir O\ncrucial O\nholiday O\nseason O\nsales O\nsuffer O\nlast O\nyear O\nbecause O\nstore O\nshelves O\nwere O\njammed O\nwith O\nblue-and-white O\nboxes O\nof O\nWindows B-MISC\n95 I-MISC\n, O\nresulting O\nin O\na O\nshortage O\nof O\nspace O\nfor O\nseasonal O\nproducts O\n, O\nsaid O\nAnn B-PER\nStephens I-PER\n, O\npresident O\nof O\nPC B-ORG\nData I-ORG\nInc I-ORG\n. O\n\nTo O\nbe O\nsure O\n, O\nsales O\nof O\nWindows B-MISC\n95 I-MISC\nand O\nthe O\naccompanying O\nOffice B-MISC\n95 I-MISC\nupgrade O\ndrove O\nMicrosoft B-ORG\nsales O\nup O\n46 O\npercent O\nlast O\nyear O\nto O\na O\nrecord O\n$ O\n8.67 O\nbillion O\nand O\ncemented O\nthe O\ncompany O\n's O\nstatus O\nas O\nthe O\nindustry O\n's O\ndominant O\ncompany O\n. O\n\nMicrosoft B-ORG\nexecutives O\nsay O\nthey O\nare O\nthrilled O\nwith O\nthe O\nsales O\nfigures O\n, O\nand O\nindustry O\nanalysts O\nestimate O\nthat O\nby O\nsometime O\nnext O\nyear O\n, O\nthe O\ninstalled O\nbase O\nof O\nWindows B-MISC\n95 I-MISC\nwill O\nsurpass O\nthat O\nof O\nthe O\nolder O\nversion O\nof O\nWindows B-MISC\n, O\nnow O\nused O\non O\nabout O\n100 O\nmillion O\ncomputers O\nworldwide O\n. O\n\nBut O\nEnderle B-PER\nsaid O\nthe O\nfigure O\ncould O\nhave O\nbeen O\neven O\nhigher O\nif O\nMicrosoft B-ORG\nhad O\ndone O\na O\nbetter O\njob O\nof O\nhandling O\nthe O\nhuge O\ndemand O\nfor O\ntechnical O\nsupport O\nfrom O\ncustomers O\nwho O\nwere O\nfrustrated O\ntrying O\nto O\ninstall O\nthe O\nsystem O\n. O\n\nHe O\nand O\nother O\nanalysts O\nsaid O\ncorporate O\nAmerica B-LOC\nadopted O\na O\ngo-slow O\napproach O\nbecause O\nMicrosoft B-ORG\nalready O\nwas O\npromoting O\nthe O\nnew O\nversion O\nof O\nits O\nhigh-end O\nWindows B-MISC\nNT I-MISC\noperating O\nsystem O\n, O\nexpected O\nto O\nbe O\navailable O\nin O\nstores O\nin O\nthe O\nnext O\nseveral O\nweeks O\n. O\n\n\" O\nMicrosoft B-ORG\nsent O\na O\nlot O\nof O\nsignals O\nthat O\nNT B-MISC\nwas O\ngoing O\nto O\nbe O\nthe O\nanswer O\n, O\n\" O\nWinkler B-PER\nsaid O\n. O\n\" O\n\nMany O\npeople O\nbegan O\nto O\nbelieve O\nthat O\nWindows B-MISC\n95 I-MISC\nwas O\nbeing O\ndownplayed O\n. O\n\" O\n\nBut O\nnow O\nthat O\nWindows B-MISC\nNT I-MISC\n4.0 I-MISC\nhas O\nbeen O\nlaunched O\n, O\nWinkler B-PER\nand O\nothers O\nbelieve O\nonly O\na O\nrelatively O\nsmall O\nproportion O\nof O\ncorporate O\nusers O\nwill O\nelect O\nto O\npay O\nthe O\nadded O\nsoftware O\nand O\nhardware O\ncosts O\nneeded O\nto O\nuse O\nit O\ninstead O\nof O\nWindows B-MISC\n95 I-MISC\n. O\n\n\" O\nWindows B-MISC\n95 I-MISC\nis O\ngoing O\nto O\ndo O\ngreat O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nThe O\nmistake O\npeople O\nmade O\nwas O\nin O\nthinking O\nit O\nwas O\ngoing O\nto O\nbe O\na O\nfast O\n, O\nsweeping O\nchange O\nrather O\nthan O\na O\nslow O\n, O\nbuilding O\nchange O\n. O\n\" O\n\n-DOCSTART- O\n\nU.S. B-LOC\nsays O\nstill O\ncommitted O\nto O\nCuba B-LOC\nmigration O\npacts O\n. O\n\nWASHINGTON B-LOC\n1996-08-22 O\n\nThe O\nUnited B-LOC\nStates I-LOC\nsaid O\non O\nThursday O\nit O\nremained O\ncommitted O\nto O\nmigration O\naccords O\nwith O\nCuba B-LOC\nand O\nwould O\ncontinue O\nto O\nrepatriate O\nintercepted O\nCuban B-MISC\nmigrants O\nwho O\nattempted O\nto O\nenter O\nU.S. B-LOC\nterritory O\nillegally O\n. O\n\nA O\nState B-ORG\nDepartment I-ORG\nstatement O\nappeared O\nin O\npart O\na O\nresponse O\nto O\nCuban B-MISC\ncomplaints O\nthat O\nWashington B-LOC\nwas O\njeopardising O\nthe O\naccords O\nby O\nfailing O\nto O\nreturn O\nsome O\nof O\nthe O\nCubans B-MISC\ninvolved O\nin O\nrecent O\nillegal O\nmigration O\nincidents O\n. O\n\n\" O\nThe O\nUnited B-LOC\nStates I-LOC\nreiterates O\nits O\nfull O\ncommitment O\nto O\nthe O\nimplementation O\n\" O\nof O\nthe O\naccords O\nsigned O\nby O\nthe O\ntwo O\ncountries O\nin O\n1994 O\nand O\n1995 O\n, O\nsaid O\nthe O\nstatement O\nby O\nspokesman O\nGlyn B-PER\nDavies I-PER\n. O\n\n\" O\nThe O\nUnited B-LOC\nStates I-LOC\nwill O\ncontinue O\nto O\nreturn O\nCuban B-MISC\nmigrants O\nintercepted O\nat O\nsea O\nwho O\nseek O\nto O\nenter O\nthe O\nUnited B-LOC\nStates I-LOC\nor O\nthe O\nGuantanamo B-LOC\nNaval I-LOC\nBase I-LOC\nillegally O\n, O\n\" O\nit O\nsaid O\n. O\n\nWashington B-LOC\nwould O\nalso O\ntake O\n\" O\nprompt O\nand O\neffective O\nlaw O\nenforcement O\naction O\n\" O\nagainst O\nalien O\nsmuggling O\nand O\nhijackings O\nfrom O\nCuba B-LOC\n, O\nit O\nadded O\n. O\n\nDavies B-PER\ntold O\nreporters O\nthe O\nstatement O\nwould O\nbe O\ndistributed O\nin O\nthe O\nCuban B-MISC\nexile O\ncommunity O\nin O\nMiami B-LOC\n\" O\nto O\nremind O\neveryone O\nof O\nthe O\nimportance O\nof O\nabiding O\nby O\nthe O\naccords O\nand O\navoiding O\ndangerous O\nattempts O\nto O\ncross O\nthe O\nstraits O\n\" O\nfrom O\nCuba B-LOC\nto O\nFlorida B-LOC\n. O\n\nHavana B-LOC\n's O\ncomplaints O\ncentred O\non O\nan O\nincident O\nin O\nwhich O\na O\nboatload O\nof O\nemigrants O\ncapsized O\nin O\nthe O\nFlorida B-LOC\nStraits I-LOC\nlast O\nweek O\nand O\ntwo O\nrecent O\naircraft O\nhijackings O\nfrom O\nCuba B-LOC\n. O\n\nSixteen O\nof O\nthose O\npicked O\nup O\nfrom O\nthe O\nboat O\nwere O\nreturned O\nto O\nCuba B-LOC\nbut O\neight O\nwere O\ntaken O\nto O\nthe O\nUnited B-LOC\nStates I-LOC\nand O\nthree O\nto O\nGuantanamo B-LOC\nBay I-LOC\n, O\na O\nU.S. B-LOC\nbase O\non O\nCuba B-LOC\n, O\nuntil O\nthey O\nemigrated O\nto O\nanother O\nnation O\n. O\n\nThe O\nmost O\nrecent O\nhijacking O\n, O\nlast O\nFriday O\n, O\ninvolved O\nthree O\nhijackers O\nand O\nthe O\npilot O\nof O\na O\nsmall O\naircraft O\n. O\n\nDavies B-PER\nsaid O\non O\nTuesday O\nthe O\npilot O\ncould O\nsoon O\nreturn O\nto O\nCuba B-LOC\nbut O\nU.S. B-LOC\nauthorities O\nplanned O\nto O\ntry O\nthe O\nhijackers O\n. O\n\nIn O\nan O\nincident O\non O\nJuly O\n7 O\n, O\na O\nCuban B-MISC\ninterior B-ORG\nministry I-ORG\nofficial O\nhijacked O\na O\ncommercial O\nplane O\nand O\nsought O\naylum O\nat O\nGuantanamo B-LOC\nBay I-LOC\n. O\n\nDavies B-PER\nsaid O\nhe O\nknew O\nof O\nno O\nplans O\nto O\nreturn O\nthe O\nman O\nto O\nCuba B-LOC\n. O\n\n-DOCSTART- O\n\nWis B-LOC\n. O\n\nsays O\nis O\nfirst O\nstate O\nto O\napply O\nfor O\nnew O\nwelfare O\n. O\n\nCHICAGO B-LOC\n1996-08-22 O\n\nIn O\nkeeping O\nwith O\nits O\npioneering O\nimage O\nin O\nthe O\narea O\nof O\nwelfare O\n, O\nWisconsin B-LOC\nwas O\nthe O\nfirst O\nstate O\nto O\nsubmit O\nan O\nadministrative O\nplan O\nunder O\nthe O\nnation O\n's O\nnew O\nwelfare O\nlaw O\n, O\nGov O\n. O\n\nTommy B-PER\nThompson I-PER\nsaid O\nThursday O\n. O\n\nAccording O\nto O\na O\nnew O\nrelease O\nfrom O\nthe O\ngovernor O\n, O\nWisconsin B-LOC\nsubmitted O\na O\nplan O\nto O\nthe O\nU.S. B-ORG\nDepartment I-ORG\nof I-ORG\nHealth I-ORG\nand I-ORG\nHuman I-ORG\nServices I-ORG\nfor O\nadministration O\nof O\nthe O\nnew O\nblock O\ngrant O\nsystem O\nfor O\nwelfare O\njust O\nminutes O\nafter O\nPresident O\nBill B-PER\nClinton I-PER\nsigned O\nthe O\nmeasure O\ninto O\nlaw O\nThursday O\n. O\n\n\" O\nAs O\nthe O\nnation O\n's O\nleader O\nin O\nwelfare O\nreform O\n, O\nWisconsin B-LOC\nis O\nfar O\nahead O\nof O\nthe O\ncurve O\nand O\nready O\nto O\ngo O\nunder O\nthis O\nnew O\nsystem O\n, O\n\" O\nThompson B-PER\nsaid O\n. O\n\nStill O\n, O\nthe O\ngovernor O\nsaid O\nthe O\nnew O\nlaw O\ndoes O\nnot O\ngo O\nas O\nfar O\nas O\nthe O\nstate O\n's O\nown O\nwelfare O\nreform O\nprogram O\n, O\ndubbed O\nW-2 B-MISC\n. O\n\nHe O\nsaid O\nthat O\ndespite O\nthe O\nnew O\nlaw O\n, O\nWisconsin B-LOC\nwill O\nstill O\nrequire O\nfederal O\nwaivers O\nallowing O\nthe O\nworking O\npoor O\nto O\nacquire O\nhealth O\ncare O\ncoverage O\nfrom O\nthe O\nstate O\n, O\na O\n60-day O\nresidency O\nrequirement O\nfor O\nparticipation O\nin O\nthe O\nwelfare O\nprogram O\n, O\nand O\nchild O\nsupport O\ncollections O\nto O\ngo O\ndirectly O\nto O\ncustodial O\nparents O\n. O\n\nThe O\nnation O\n's O\nnew O\nwelfare O\nreform O\nlaw O\nlimits O\neligibility O\n, O\ngives O\nstates O\nmore O\npower O\nand O\nends O\ndirect O\nfederal O\naid O\nfor O\npoor O\nchildren O\n. O\n\n-- O\nKaren B-PER\nPierog I-PER\n, O\n312-408-8647 O\n\n-DOCSTART- O\n\nSnoozing O\nVietnamese B-MISC\nman O\ntakes O\nslow O\ntrain O\nto O\nAlaska B-LOC\n. O\n\nANCHORAGE B-LOC\n, O\nAlaska B-LOC\n1996-08-22 O\n\nA O\nVietnamese B-MISC\nman O\nwho O\ntried O\nto O\ntake O\na O\nsnooze O\nin O\na O\nrailway O\nboxcar O\nin O\nCanada B-LOC\nfound O\nhimself O\nlocked O\nin O\nand O\nbound O\nfor O\nAlaska B-LOC\nwith O\nno O\nfood O\nor O\nwater O\n. O\n\nOfficials O\nin O\nthe O\nport O\nof O\nWhittier B-LOC\nsaid O\non O\nThursday O\nthat O\nthey O\nfound O\nTuan B-PER\nQuac I-PER\nPhan I-PER\n, O\n29 O\n, O\ndehydrated O\n, O\nfamished O\nand O\nterrified O\nafter O\nsailing O\nto O\nAlaska B-LOC\nfrom O\nCanada B-LOC\nin O\nthe O\nboxcar O\nloaded O\non O\na O\nbarge O\n, O\na O\ntrip O\nthat O\ntakes O\nabout O\nfive O\ndays O\n. O\n\nSgt O\n. O\n\nDan B-PER\nJewell I-PER\nof O\nthe O\nWhittier B-LOC\n, O\nAlaska B-LOC\npolice O\ndepartment O\ndescribed O\nPhan B-PER\nas O\n\" O\nextremely O\ncooperative O\n\" O\n. O\n\" O\n\nSeeing O\nme O\nin O\nmy O\nuniform O\n, O\nhe O\nkept O\nsaying O\n, O\nJail O\nbetter O\n. O\n\nJail O\nbetter O\n. O\n' O\n\n\" O\n\nPhan B-PER\n's O\naccidental O\njourney O\nstarted O\nlast O\nweek O\nin O\nPrince B-LOC\nRupert I-LOC\n, O\nBritish B-LOC\nColumbia I-LOC\n, O\nwhere O\nhe O\nwas O\nsearching O\nfor O\na O\nfishing O\njob O\n, O\nJewell B-PER\nsaid O\n. O\n\n\" O\nHe O\nhad O\nclimbed O\nup O\nin O\nthis O\nboxcar O\nto O\nget O\nout O\nof O\nthe O\nweather O\nand O\nto O\nget O\nsome O\nsleep O\n, O\n\" O\nJewell B-PER\nsaid O\n. O\n\" O\n\nThe O\nnext O\nthing O\nyou O\nknow O\n, O\nthe O\nboxcar O\nis O\ncoupled O\nup O\nand O\nloaded O\nup O\nto O\na O\nbarge O\nand O\nheaded O\nnorth O\n. O\n\" O\n\nPolice O\nfound O\nPhan B-PER\nlate O\non O\nMonday O\nwhen O\nthe O\nboxcar O\n, O\nwhich O\nwas O\ntransporting O\nlumber O\n, O\nwas O\nopened O\nat O\nWhittier B-LOC\n, O\na O\nport O\nin O\nwestern O\nPrince B-LOC\nWilliam I-LOC\nSound I-LOC\n. O\n\nOfficials O\nfed O\nPhan B-PER\nsome O\nsoup O\n, O\ngave O\nhim O\nmedical O\ncare O\n, O\nkept O\nhim O\novernight O\nand O\nthen O\nfed O\nhim O\na O\nlarge O\nbreakfast O\n. O\n\n-DOCSTART- O\n\nState O\n, O\nfederal O\nagents O\nprobe O\nArkansas B-LOC\nchurch O\nfires O\n. O\n\nSteve B-PER\nBarnes I-PER\n\nLITTLE B-LOC\nROCK I-LOC\n, O\nArk B-LOC\n. O\n\n1996-08-22 O\n\nState O\nand O\nfederal O\nagents O\non O\nThursday O\nsifted O\nthrough O\nthe O\nrubble O\nof O\ntwo O\npredominantly O\nblack O\nArkansas B-LOC\nchurches O\nthat O\nburned O\nwithin O\nminutes O\nof O\none O\nanother O\nlate O\nTuesday O\nand O\nearly O\nWednesday O\n. O\n\nBoth O\nchurches O\nwere O\nin O\nthe O\nMississippi B-LOC\ndelta O\nregion O\nof O\nArkansas B-LOC\n, O\nabout O\n90 O\nmiles O\n( O\n145 O\nkms O\n) O\nsoutheast O\nof O\nLittle B-LOC\nRock I-LOC\n, O\nand O\nwere O\nlocated O\nwithin O\nthree O\nmiles O\nof O\none O\nanother O\n. O\n\n\" O\nWe O\n're O\ninvestigating O\nwith O\nthe O\nidea O\nthat O\nboth O\nfires O\nmay O\nbe O\narson O\n, O\nbut O\nthat O\nhas O\nn't O\nbeen O\nconclusively O\nestablished O\n, O\n\" O\nsaid O\nWayne B-PER\nJordan I-PER\n, O\na O\nspokesman O\nfor O\nthe O\nArkansas B-ORG\nState I-ORG\nPolice I-ORG\n. O\n\nAgents O\nof O\nthe O\nF.B.I. B-ORG\nand O\nthe O\nBureau B-ORG\nof I-ORG\nAlcohol I-ORG\n, I-ORG\nTobacco I-ORG\nand I-ORG\nFirearms I-ORG\nwere O\nalso O\nat O\nthe O\nscene O\n, O\nJordan B-PER\nsaid O\n. O\n\nMount B-LOC\nZion I-LOC\nMissionary I-LOC\nBaptist I-LOC\nChurch I-LOC\nand O\nSt. B-LOC\nMatthews I-LOC\nMissionary I-LOC\nBaptist I-LOC\nChurch I-LOC\nwere O\nboth O\nframe O\nstructures O\n, O\neach O\nnear O\nTurner B-LOC\n, O\nArkansas B-LOC\n, O\na O\nsmall O\ncommunity O\nsurrounded O\nby O\ncotton O\nand O\nsoybean O\nfields O\n. O\n\n\" O\nThis O\nis O\nrural O\nArkansas B-LOC\n. O\n\nI O\n'm O\nsurprised O\nanyone O\ncould O\neven O\nfind O\nus O\nout O\nhere O\n, O\n\" O\nsaid O\nFannie B-PER\nJohnson I-PER\n, O\na O\nmember O\nof O\nSt. B-LOC\nMatthew I-LOC\n's I-LOC\n, O\nwho O\nsaid O\nshe O\nbelieved O\narson O\nwas O\nto O\nblame O\n. O\n\nOthers O\nconnected O\nwith O\nthe O\ntwo O\nchurches O\nsaid O\nthey O\nshared O\nthat O\nsuspicion O\n, O\nalthough O\nall O\nsaid O\nthey O\nknew O\nof O\nno O\nmotive O\nand O\nno O\nracial O\ntension O\nin O\nthe O\narea O\n. O\n\n\" O\nIt O\n's O\nsad O\nsomeone O\nwould O\nhave O\nthat O\nkind O\nof O\nspite O\nin O\ntheir O\nheart O\n, O\n\" O\nsaid O\nRev. O\nJerome B-PER\nTurner I-PER\n, O\npastor O\nof O\nMount B-LOC\nZion I-LOC\nMissionary I-LOC\nBaptist I-LOC\nChurch I-LOC\n. O\n\nArkansas B-LOC\nhas O\nbeen O\nspared O\nthe O\nloss O\nof O\npredominantly O\nblack O\nchurches O\nto O\narson O\n, O\na O\nwave O\nthat O\nhas O\nclaimed O\nan O\nestimated O\n30 O\nhouses O\nof O\nworship O\nacross O\nthe O\nsouth O\nin O\nthe O\npast O\nseveral O\nmonths O\n. O\n\nA O\nblack O\nchurch O\nnear O\nCamden B-LOC\n, O\nArkansas B-LOC\n, O\nabout O\n100 O\nmiles O\n( O\n161 O\nkms O\n) O\nsouth O\nof O\nLittle B-LOC\nRock I-LOC\n, O\nburned O\nin O\nJuly O\n, O\nbut O\nfederal O\nagents O\nhave O\nnot O\ndetermined O\nthe O\ncause O\n. O\n\n-DOCSTART- O\n\nRESEARCH O\nALERT O\n- O\nRoyal B-ORG\nOak I-ORG\ninitiated O\n. O\n\n-- O\nEVEREN B-ORG\nSecurities I-ORG\nInc I-ORG\nsaid O\nFriday O\nit O\ninitiated O\ncoverage O\nof O\nRoyal B-ORG\nOak I-ORG\nMines I-ORG\nInc I-ORG\nwith O\nan O\noutperform O\nrating O\n. O\n\n-- O\nIt O\nset O\nearnings O\nestimates O\nof O\n$ O\n0.08 O\na O\nshare O\nfor O\nfiscal O\n1996 O\n, O\n$ O\n0.13 O\nfor O\n1997 O\n, O\n$ O\n0.40 O\nfor O\n1998 O\nand O\n$ O\n0.43 O\nfor O\n1999 O\n. O\n\n-- O\n\" O\nBased O\non O\nour O\nsimulated O\nproduction O\n, O\nincome O\nand O\ncash O\nflow O\nmodels O\n, O\ncommon O\nshares O\nof O\nRoyal B-ORG\nOak I-ORG\nare O\nat O\na O\nsignificant O\ndiscount O\nto O\nthe O\nindustry O\naverages O\n, O\n\" O\nEVEREN B-ORG\nsaid O\n. O\n\n-- O\nThe O\nshort-term O\nprice O\nobjective O\nis O\n$ O\n5 O\na O\nshare O\nand O\nthe O\nlong-term O\nobjective O\nis O\n$ O\n9 O\n. O\n\n-- O\nRoyal B-ORG\nOak I-ORG\nshares O\nwere O\ndown O\n1/16 O\nat O\n3-11/16 O\n. O\n\nReuters B-ORG\nChicago I-ORG\nNewsdesk I-ORG\n- O\n312-408-8787 O\n\n-DOCSTART- O\n\nSunGard B-ORG\nto O\nbuy O\nCheckFree B-ORG\nunit O\n. O\n\nSAN B-LOC\nMATEO I-LOC\n, O\nCalif. B-LOC\n1996-08-23 O\n\nSunGard B-ORG\nShareholder I-ORG\nSystems I-ORG\nInc I-ORG\n, O\na O\nsubsidiary O\nof O\nSunGard B-ORG\nData I-ORG\nSystems I-ORG\nInc I-ORG\n, O\nsaid O\nit O\nhad O\nentered O\ninto O\na O\ndefinitive O\nagreement O\nto O\nbuy O\nthe O\nSecurities B-ORG\nProducts I-ORG\nBusiness I-ORG\nunit O\nof O\nCheckFree B-ORG\nCorp I-ORG\n. O\n\nThe O\ncompany O\nsaid O\nin O\na O\nstatement O\non O\nFriday O\nthe O\ndeal O\nwas O\nexpected O\nto O\nbe O\nfinalized O\nin O\nSeptember O\n. O\n\nTerms O\nwere O\nnot O\ndisclosed O\n. O\n\nThe O\npurchase O\nis O\nnot O\nexpected O\nto O\nhave O\na O\nmaterial O\neffect O\no O\nSunGard B-ORG\n's O\nfinancial O\ncondition O\nor O\nresults O\nof O\noperations O\n. O\n\n-- O\nNew B-LOC\nYork I-LOC\nnewsroom O\n, O\n( O\n212 O\n) O\n859-1610 O\n\n-DOCSTART- O\n\nAlpha B-ORG\nTechs I-ORG\ncloses O\nLockhart B-ORG\npurchase O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-23 O\n\nAlpha B-ORG\nTechnologies I-ORG\nGroup I-ORG\nInc I-ORG\nsaid O\nit O\nhad O\nclosed O\non O\nits O\nagreement O\nto O\nacquire O\nLockhart B-ORG\nIndustries I-ORG\nInc I-ORG\n. O\n\nThe O\ncompany O\nsaid O\nin O\na O\nstatement O\nlate O\non O\nThursday O\nthat O\nit O\nissued O\n280,556 O\nshares O\nof O\ncommon O\nstock O\nfor O\nthe O\nstock O\nof O\nLockhart B-ORG\n. O\n\nThese O\nshares O\nare O\nsubject O\nto O\npost-closing O\nadjustments O\n. O\n\nLockhart B-ORG\n, O\nbased O\nin O\nParamount B-LOC\n, O\nCalif. B-LOC\n, O\nis O\na O\ndesigner O\nand O\nmanufacturer O\nof O\nsophisticated O\nthermal O\nmanagement O\nproducts O\n. O\n\n-- O\nNew B-LOC\nYork I-LOC\nnewsroom O\n, O\n( O\n212 O\n) O\n859-1610 O\n\n-DOCSTART- O\n\nAnalysts O\nhold O\nDutch B-ORG\nPTT I-ORG\nestimates O\n. O\n\nAMSTERDAM B-LOC\n1996-08-23 O\n\nDutch B-MISC\npost O\nand O\ntelecoms O\ngroup O\nKoninklijke B-ORG\nPTT I-ORG\nNederland I-ORG\nNV I-ORG\n's O\n( O\nDutch B-ORG\nPTT I-ORG\n) O\nfirst O\nhalf O\nresults O\ncame O\nmarginally O\nbelow O\nmost O\nanalysts O\n' O\nforecasts O\n, O\ngiving O\nscant O\ngrounds O\nto O\nadjust O\nfull O\nyear O\nestimates O\n, O\nanalysts O\nsaid O\non O\nFriday O\n. O\n\nPTT B-ORG\nearlier O\nannounced O\nan O\n8.5 O\npercent O\nrise O\nin O\nnet O\nprofit O\nfor O\nthe O\nfirst O\nsix O\nmonths O\nof O\n1996 O\nto O\n1.209 O\nbillion O\nguilders O\n, O\na O\nhair O\n's O\nbreadth O\nbelow O\nthe O\n1.210-1.236 O\nbillion O\nforecast O\nrange O\n. O\n\n\" O\nThey O\nwere O\npretty O\nmuch O\nin O\nline O\nwith O\nour O\nestimate O\nof O\n1.210 O\nbillion O\n, O\n\" O\nsaid O\nPeter B-PER\nRoe I-PER\n, O\nat O\nParibas B-ORG\nin O\nLondon B-LOC\n. O\n\" O\n\nAs O\nwe O\nexpected O\nvolume O\ngrowth O\nwas O\nquite O\ngood O\n... O\n\nthere O\n's O\nreally O\nno O\nreason O\nto O\nchange O\nour O\nforecast O\nand O\nour O\nlargely O\npositive O\nview O\non O\nthe O\nstock O\n. O\n\" O\n\n\" O\nComing O\njust O\na O\nmillion O\nguilders O\nunder O\nthe O\nforecast O\nrange O\nis O\nn't O\noverwhelmingly O\nsurprising O\n, O\n\" O\nsaid O\nING B-ORG\nanalyst O\nSteven B-PER\nVrolijk I-PER\n, O\nwho O\nis O\ncontinuing O\nto O\nlook O\nfor O\na O\nnine O\nto O\n10 O\npercent O\nrise O\nin O\n1996 O\nearnings O\n. O\n\n\" O\nThey O\n've O\ngot O\na O\nvery O\nsound O\ndomestic O\nbusiness O\nwhich O\nis O\ndoing O\nvery O\nwell O\n, O\nwe O\nremain O\npositive O\non O\nthe O\nstock O\n, O\n\" O\nsaid O\nRoe B-PER\n. O\n\" O\n\nWe O\nthink O\nit O\n's O\na O\nsolid O\nperformer O\nin O\nthe O\nDutch B-MISC\nmarket O\n. O\n\" O\n\nRoe B-PER\nsaid O\nhe O\nwas O\nsticking O\nby O\nhis O\nforecast O\nof O\na O\n2.45 O\nbillion O\nguilder O\nnet O\nfor O\n1996 O\n. O\n\nDutch B-ORG\nPTT I-ORG\nearlier O\non O\nFriday O\nrepeated O\na O\nforecast O\nit O\nwould O\nimprove O\non O\n1995 O\n's O\n2.26 O\nbillion O\nguilder O\nnet O\nprofit O\nfor O\nthe O\nwhole O\nyear O\nof O\n1996 O\n. O\n\nBy O\n1403 O\nGMT B-MISC\nthe O\nshares O\nwere O\ndown O\n1.70 O\nguilders O\nto O\n61.00 O\nguilders O\n, O\nfalling O\nin O\na O\nweaker O\nAmsterdam B-LOC\nbourse O\n. O\n\n-- O\nKeiron B-PER\nHenderson I-PER\n, O\nAmsterdam B-ORG\nNewsroom I-ORG\n+31 O\n20 O\n504 O\n5000 O\n\n-DOCSTART- O\n\nBoskalis B-ORG\nupgrades O\n1996 O\noutlook O\n. O\n\n[ O\nCORRECTED O\n13:12 O\nGMT B-MISC\n] O\n\nPAPENDRECHT B-LOC\n, O\nNetherlands B-LOC\n1996-08-23 O\n\nDredging O\ngroup O\nKoninklijke B-ORG\nBoskalis I-ORG\nWestminster I-ORG\nNV I-ORG\nsaid O\non O\nFriday O\nit O\nexpected O\nhigher O\nturnover O\nand O\nprofits O\nfor O\nthe O\nsecond O\nhalf O\nof O\n1996 O\n( O\ncorrects O\nfrom O\nthe O\nfull O\nyear O\n1996 O\n) O\n. O\n\n\" O\nAn O\nimprovement O\nis O\nexpected O\nin O\ncapacity O\nutilisation O\n, O\nturnover O\nand O\nprofits O\n, O\n\" O\nthe O\ncompany O\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nworld O\n's O\nlargest O\ndredger O\nsaid O\nin O\nMarch O\nthat O\nit O\nwas O\nuncertain O\nwhether O\nit O\ncould O\nhold O\n1996 O\nfull-year O\nprofit O\nsteady O\nat O\nthe O\nprevious O\nyear O\n's O\n70.9 O\nmillion O\nguilders O\n, O\nbut O\nadded O\nlong-term O\nprospects O\nwere O\ngood O\n. O\n\nBoskalis B-ORG\nreported O\n1996 O\nfirst-half O\nnet O\nprofit O\nfell O\nto O\n27.5 O\nmillion O\nguilders O\nfrom O\na O\nyear-earlier O\n41.4 O\nmillion O\n. O\n\n-DOCSTART- O\n\nGreek B-MISC\npresident O\ndissolves O\nparliament O\nfor O\nsnap O\nvote O\n. O\n\nATHENS B-LOC\n1996-08-23 O\n\nGreek B-MISC\nPresident O\nCostis B-PER\nStephnopoulos I-PER\nsigned O\na O\ndecree O\non O\nThursday O\nordering O\nthe O\ndissolution O\nof O\nthe O\n300-seat O\nparliament O\nahead O\nof O\nsnap O\nelections O\non O\nSeptember O\n22 O\n. O\n\n\" O\nThe O\nPresident O\nof O\nthe O\nRepublic B-MISC\nCostis B-PER\nStephanopoulos I-PER\nsigned O\nthe O\ndecree O\nfor O\nthe O\ndissolution O\nof O\nparliament O\n, O\n\" O\na O\npresidency O\nstatement O\nsaid O\n. O\n\nSocialist O\nPrime O\nMinister O\nCostas B-PER\nSimitis I-PER\nannounced O\nthe O\nsnap O\npoll O\non O\nThursday O\nciting O\nproblems O\nwith O\nthe O\neconomy O\n, O\nthe O\ncountry O\n's O\nconvergence O\nwith O\nthe O\nEuropean B-ORG\nUnion I-ORG\nand O\ntense O\nrelations O\nwith O\nneighbouring O\nTurkey B-LOC\n. O\n\nElections O\nwere O\noriginally O\nscheduled O\nto O\nbe O\nheld O\nin O\nOctober O\nnext O\nyear O\n. O\n\n-DOCSTART- O\n\nLibyan B-MISC\nman O\nmurdered O\nin O\nMalta B-LOC\n. O\n\nVALLETTA B-LOC\n1996-08-23 O\n\nA O\nLibyan B-MISC\nman O\nhas O\nbeen O\nfound O\nstabbed O\nto O\ndeath O\nin O\nMalta B-LOC\n, O\npolice O\nsaid O\non O\nFriday O\n. O\n\nThey O\nsaid O\nthe O\nbody O\nof O\nAmer B-PER\nHishem I-PER\nAli I-PER\nMohammed I-PER\n, O\n23 O\n, O\nwas O\nfound O\nin O\na O\npool O\nof O\nblood O\nin O\nSliema B-LOC\n, O\nseven O\nkm O\n( O\nfour O\nmiles O\n) O\nfrom O\nValletta B-LOC\n, O\non O\nWednesday O\nmorning O\n. O\n\nHe O\nappeared O\nto O\nhave O\nbeen O\nkilled O\non O\nTuesday O\nnight O\n, O\nsuffering O\nat O\nleast O\neight O\nstab O\nwounds O\n. O\n\nPolice O\nCommissioner O\nGeorge B-PER\nGrech I-PER\nsaid O\npolice O\nwere O\ninvestigating O\nthe O\npossibility O\nthat O\nMohammed B-PER\nhad O\nlinks O\nto O\nan O\nIslamic B-MISC\nmilitant O\ngroup O\nas O\nreported O\nby O\nthe O\nlocal O\npress O\n. O\n\n\" O\nWhat O\nwe O\nknow O\nis O\nthat O\nhe O\nwas O\na O\nfervant O\nreligious O\nman O\n, O\nwe O\ncannot O\nexclude O\nanything O\nin O\ninvestigations O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nDeutsche B-ORG\nBahn I-ORG\nH1 O\npre-tax O\nprofit O\nup O\n17.5 O\npct O\n. O\n\nFRANKFURT B-LOC\n1996-08-23 O\n\nSix O\nmonths O\nto O\nJune O\n30 O\n\n( O\nin O\nmillions O\nof O\nmarks O\nunless O\nstated O\n) O\n\nGroup O\npre-tax O\nprofit O\n188 O\nvs O\n160 O\n\nGroup O\nsales O\n14,600 O\nup O\n3.3 O\npct O\n\nNOTE O\n- O\nFull O\nname O\nof O\nthe O\nstate-owned O\nGerman B-MISC\nrailway O\ncompany O\nis O\nDeutsche B-ORG\nBahn I-ORG\nAG I-ORG\n. O\n\nThe O\ncompany O\nis O\nearmarked O\nfor O\neventual O\nprivatisatio O\n\nalso O\ncovers O\nsnap O\nFAT8222 O\n\nRevenue O\nfrom O\nlong-distance O\npassenger O\n\ntraffic O\n2,500 O\nup O\n6.4 O\npct O\n\nRevenue O\nfrom O\ncommuter O\ntraffic O\n5,400 O\nup O\n4.6 O\npct O\n\nRevenue O\nfrom O\nfreight O\ntraffic O\n3,200 O\ndown O\n5.1 O\npct O\n\nGroup O\nworkforce O\non O\nJune O\n30 O\n300,962 O\ndown O\n3.7 O\noct O\n\nNOTE O\n- O\nSales O\n, O\nprofit O\ncompare O\nwith O\nfirst O\nhalf O\nof O\n1995 O\n, O\nworkforce O\ncompares O\nwith O\nDec O\n31 O\n. O\n\n-- O\nFrankfurt B-ORG\nNewsroom I-ORG\n, O\n+49 O\n69 O\n756525 O\n\n-DOCSTART- O\n\nSea O\nlion O\npaparazzi O\nto O\nkeep O\ntabs O\non O\nwhales O\n. O\n\nLONDON B-LOC\n1996-08-22 O\n\nU.S. B-LOC\nmarine O\nbiologists O\nhave O\ntrained O\na O\npair O\nof O\nsea O\nlions O\nto O\ntag O\nand O\nphotograph O\nelusive O\nwhales O\nas O\nthey O\ncruise O\nthrough O\nthe O\nPacific B-LOC\ndepths O\n, O\nNew B-ORG\nScientist I-ORG\nmagazine O\nreported O\non O\nThursday O\n. O\n\nJames B-PER\nHarvey I-PER\nand O\nJennifer B-PER\nHurley I-PER\nof O\nthe O\nMoss B-ORG\nLanding I-ORG\nMarine I-ORG\nLaboratories I-ORG\nin O\nCalifornia B-LOC\nsay O\ntheir O\nsea O\nlions O\n, O\nnatural O\ncompanions O\nof O\nmany O\nspecies O\nof O\nwhale O\n, O\ncan O\ngo O\nwhere O\nno O\nman O\nor O\nwoman O\nhas O\never O\ngone O\nbefore O\n. O\n\n\" O\nAny O\ndiver O\nknows O\nthat O\nwhen O\na O\nwhale O\ngets O\ngoing O\nyou O\nca O\nn't O\nkeep O\nup O\n, O\n\" O\nHarvey B-PER\ntold O\nthe O\nmagazine O\n. O\n\" O\n\nThat O\nis O\nwhy O\nwe O\nknow O\nonly O\nabout O\nfive O\npercent O\nof O\nwhat O\nwhales O\ndo O\n. O\n\" O\n\nThe O\nsea O\nlions O\n-- O\n17-year-old O\nBeaver B-PER\nand O\nnine-year-old O\nSake B-PER\n-- O\nhave O\nundergone O\nsix O\nyears O\nof O\ntraining O\nfor O\ntheir O\nmission O\n. O\n\nBeaver B-PER\nonce O\nworked O\nfor O\nthe O\nU.S. B-ORG\nNavy I-ORG\nand O\nSake B-PER\nis O\nan O\namusement O\npark O\nveteran O\n. O\n\nHarvey B-PER\nsaid O\nthey O\ncould O\naccurately O\ntag O\nwhales O\nwith O\na O\nradio O\ntransmitter O\n, O\nand O\ncould O\nalso O\nswim O\nall O\nthe O\nway O\naround O\none O\nof O\nthe O\ngiant O\nmammals O\n, O\nfilming O\nit O\nwith O\na O\nvideo O\ncamera O\n. O\n\nTheir O\nfirst O\nassignment O\n, O\nlater O\nthis O\nyear O\n, O\nwill O\nbe O\ndocumenting O\nhumpback O\nwhale O\nmigration O\noff O\nMonterey B-LOC\n, O\nCalifornia B-LOC\n. O\n\nThe O\narticle O\ndid O\nnot O\nspell O\nout O\nexactly O\nhow O\nthe O\nsea O\nlions O\nmanage O\nto O\ntag O\nthe O\nwhales O\nbut O\nsaid O\nin O\ntraining O\nthey O\nwere O\ntaught O\nto O\nstick O\na O\nradio O\ntransmitter O\non O\nto O\na O\nplastic O\nmodel O\nof O\na O\nwhale O\nusing O\nsuction O\ncups O\n. O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nAustralia B-ORG\nSenate I-ORG\njeopardises O\nrate O\ncut O\n- O\nHoward B-PER\n. O\n\nCANBERRA B-LOC\n1996-08-23 O\n\nAustralian B-MISC\nPrime O\nMinister O\nJohn B-PER\nHoward I-PER\nsaid O\nthe O\npossibility O\nof O\nlower O\ninterest O\nrates O\nwas O\nbeing O\njeopardised O\nby O\nParliament O\n's O\nupper O\nhouse O\nwhere O\nopposition O\nparties O\nplanned O\nto O\nscrutinise O\nthe O\n1996/97 O\nbudget O\n. O\n\n\" O\nEvery O\ntime O\nthe O\nSenate B-ORG\nhacks O\naway O\nat O\nthe O\nbudget O\n, O\nthey O\nhack O\naway O\nat O\nthe O\nlower O\ninterest O\nrate O\nenvironment O\n, O\n\" O\nHoward B-PER\ntold O\nreporters O\non O\nThursday O\nnight O\nafter O\nattending O\na O\nLiberal B-ORG\nParty I-ORG\nfunction O\n. O\n\nSenior O\nministers O\nhave O\nrepeatedly O\nwarned O\nsince O\nthe O\nfiscally-tight O\nbudget O\nwas O\nhanded O\ndown O\non O\nTuesday O\nnight O\nthat O\nthe O\nchance O\nof O\nlower O\nofficial O\nrates O\ncould O\nbe O\nhampered O\nin O\nthe O\nSenate B-ORG\n. O\n\nThe O\nbudget O\ncontained O\nsharp O\nspending O\ncuts O\nin O\nareas O\nsuch O\nas O\nthe O\nlabour O\nmarket O\nto O\nreduce O\nthe O\ndeficit O\nto O\nabout O\nA$ B-MISC\n5.6 O\nbillion O\n. O\n\nThe O\nconservative O\ngovernment O\n's O\nplan O\nfor O\nreform O\nof O\nthe O\nindustrial O\nrelations O\nenvironment O\nand O\nto O\npartially O\nsell O\nTelstra B-ORG\nhas O\nalso O\nbeen O\nopposed O\nby O\nparties O\nin O\nthe O\nSenate B-ORG\nsuch O\nas O\nthe O\nGreens B-ORG\nand O\nAustralian B-ORG\nDemocrats I-ORG\nas O\nwell O\nas O\nthe O\nofficial O\nopposition O\n, O\nthe O\nLabor B-ORG\nParty I-ORG\n. O\n\nOfficial O\ncash O\nrates O\nwere O\nlast O\ncut O\non O\nJuly O\n31 O\nto O\n7.0 O\npercent O\n. O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n373-1800 O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nToyota B-ORG\nAustralia I-ORG\nworkers O\nto O\nreturn O\nto O\nwork O\n. O\n\nMELBOURNE B-LOC\n1996-08-23 O\n\nOver O\n2,000 O\nstriking O\nworkers O\nvoted O\non O\nFriday O\nto O\nreturn O\nto O\nwork O\non O\nMonday O\nat O\nToyota B-ORG\nAustralia I-ORG\n's O\nMelbourne B-LOC\nassembly O\nline O\n, O\nending O\na O\ntwo-week O\nstoppage O\n. O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nNiugini B-ORG\nshares O\nsurge O\non O\nbid O\ntalk O\n. O\n\nSYDNEY B-LOC\n1996-08-23 O\n\nShares O\nin O\ngold O\nminer O\nNiugini B-ORG\nMining I-ORG\nLtd I-ORG\nsurged O\n38 O\ncents O\nto O\nA$ B-MISC\n3.75 O\nearly O\non O\nFriday O\nfollowing O\nconfirmation O\non O\nThursday O\nfrom O\nBattle B-ORG\nMountain I-ORG\nGold I-ORG\nthat O\nit O\nwas O\nconsidering O\nacquiring O\nthe O\n49.6 O\npercent O\nof O\nNiugini B-ORG\nit O\ndid O\nnot O\nalready O\nown O\n. O\n\nNiugini B-ORG\nMining I-ORG\nLtd I-ORG\nsaid O\non O\nThursday O\nthat O\nBattle B-ORG\nMountain I-ORG\nhad O\ninitiated O\ntalks O\nabout O\nacquiring O\nthe O\nshares O\nin O\nNiugini B-ORG\nit O\ndoes O\nnot O\nalready O\nown O\n. O\n\" O\n\nBattle B-ORG\nMountain I-ORG\nare O\nset O\nto O\ntake O\nout O\nthe O\nminorities O\nthere O\nsoon O\n, O\n\" O\nsaid O\na O\nSydney B-LOC\nbroker O\n. O\n\nNiugini B-ORG\nholds O\ncopper O\nand O\ngold O\nmining O\ninterests O\nin O\nAustralia B-LOC\n, O\nChile B-LOC\nand O\nPapua B-LOC\nNew I-LOC\nGuinea I-LOC\n, O\nwhere O\nit O\nhas O\na O\n17.2 O\npercent O\nstake O\nin O\nthe O\nLihir B-ORG\ngold O\nproject O\n. O\n\nBy O\n11.25 O\na.m. O\n( O\n0025 O\nGMT B-MISC\n) O\n, O\nNiugini B-ORG\nMining I-ORG\nshares O\nwere O\nat O\nA$ B-MISC\n3.65 O\n, O\nup O\n28 O\ncents O\non O\nturnover O\nof O\n108,288 O\nshares O\n. O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373 O\n1800 O\n\n-DOCSTART- O\n\nSouth B-MISC\nKorean I-MISC\nstudents O\nthrow O\n\" O\nirreplaceable O\n\" O\nrocks O\n. O\n\nSEOUL B-LOC\n1996-08-23 O\n\nStudents O\nat O\nSouth B-LOC\nKorea I-LOC\n's O\nYonsei B-ORG\nUniversity I-ORG\nthrew O\nmore O\nthan O\njust O\nordinary O\nrocks O\nat O\nriot O\npolice O\n-- O\nsome O\nwere O\nsamples O\nthat O\nthe O\ngeology O\ndepartment O\nhad O\ntaken O\n30 O\nyears O\nto O\ncollect O\n, O\nnewspapers O\nreported O\non O\nFriday O\n. O\n\nGeology O\nprefessors O\nwere O\nquoted O\nas O\nsaying O\nthat O\ntheir O\ncollection O\nof O\n10,000 O\nrocks O\n, O\ngathered O\nfrom O\nacross O\nthe O\nnation O\nand O\nabroad O\n, O\nwere O\nirreplaceable O\n. O\n\n\" O\nThese O\nare O\nnot O\nlike O\nmissing O\nwindow O\npanes O\nor O\nbroken O\ndesks O\n. O\n\nThey O\nare O\nlost O\nforever O\n, O\n\" O\nsaid O\none O\nprofessor O\n. O\n\nThe O\nstudents O\nstaged O\na O\nviolent O\nnine-day O\ndemonstration O\nat O\nthe O\nuniversity O\nto O\ndemand O\nunification O\nwith O\nNorth B-LOC\nKorea I-LOC\n. O\n\nPolice O\nended O\nthe O\nprotest O\non O\nTuesday O\nafter O\nstorming O\nthe O\ncampus O\n. O\n\n-DOCSTART- O\n\nS. B-MISC\nKorean I-MISC\nwon O\nends O\nup O\non O\ndollar O\nposition O\nunwinding O\n. O\n\nSEOUL B-LOC\n1996-08-23 O\n\nThe O\nwon O\nrose O\nagainst O\nthe O\ndollar O\non O\nFriday O\nas O\nbanks O\nunwound O\ndollar O\npositions O\non O\nthe O\nbelief O\nthat O\nthe O\nwon O\nwould O\ncontinue O\nto O\nstrengthen O\n, O\ndealers O\nsaid O\n. O\n\nThe O\nwon O\nclosed O\nat O\n818.10 O\n, O\nafter O\nopening O\nat O\n819.10 O\n. O\n\nIt O\nranged O\nfrom O\n817.60 O\nto O\n819.30 O\n. O\n\n\" O\nThe O\ndollar O\nis O\noverbought O\nat O\nthe O\nmoment O\n, O\n\" O\nsaid O\na O\nwestern O\nbank O\ndealer O\n. O\n\" O\n\nThe O\ncentral O\nbank O\n's O\ninsistent O\nintervention O\njust O\nabove O\nthe O\n820 O\nlevel O\nconvinced O\nplayers O\nthat O\nit O\nis O\nserious O\nabout O\nsupporting O\nthe O\nwon O\n. O\n\nSo O\nsome O\nforeign O\nbanks O\nbegan O\nunwinding O\ntheir O\ndollar O\npositions O\n. O\n\" O\n\n-DOCSTART- O\n\nOrii B-ORG\n- O\n96/97 O\ngroup O\nforecast O\n. O\n\nTOKYO B-LOC\n1996-08-23 O\n\nYear O\nto O\nMay O\n31 O\n, O\n1997 O\n\n( O\nin O\nbillions O\nof O\nyen O\nunless O\nspecified O\n) O\n\nLATEST O\nACTUAL O\n\n( O\nGroup O\n) O\nFORECAST O\nYEAR-AGO O\n\nSales O\n8.70 O\n8.67 O\n\nCurrent O\nprft O\n7 O\nmln O\nloss O\n371 O\nmln O\n\nNet O\nnil O\nloss O\n447 O\nmln O\n\nEPS O\nnil O\nyen O\nloss O\n48.61 O\nyen O\n\nNOTE O\n- O\nOrii B-ORG\nCorp I-ORG\nmakes O\nautomation O\nequipment O\n. O\n\n-DOCSTART- O\n\nOrii B-ORG\n- O\n95/96 O\ngroup O\nresults O\n. O\n\nTOKYO B-LOC\n1996-08-23 O\n\nYear O\nto O\nMay O\n31 O\n, O\n1996 O\n\n( O\nGroup O\n) O\n( O\nin O\nbillions O\nof O\nyen O\nunless O\nspecified O\n) O\n\nSales O\n8.67 O\nvs O\n9.33 O\n\nOperating O\nloss O\n286 O\nmillion O\nvs O\nloss O\n48 O\nmillion O\n\nCurrent O\nloss O\n371 O\nmillion O\nvs O\nloss O\n278 O\nmillion O\n\nNet O\nloss O\n447 O\nmillion O\nvs O\nloss O\n350 O\nmillion O\n\nEPS O\nloss O\n48.61 O\nyen O\nvs O\nloss O\n38.11 O\nyen O\n\nDiluted O\nEPS O\n- O\nvs O\n- O\n\nNOTE O\n- O\nOrii B-ORG\nCorp I-ORG\nmakes O\nautomation O\nequipment O\n. O\n\n-DOCSTART- O\n\nChina B-LOC\ncopper O\nstocks O\nowned O\nby O\nstate O\nreserve O\n- O\ntrade O\n. O\n\nLynne B-PER\nO'Donnell I-PER\n\nHONG B-LOC\nKONG I-LOC\n1996-08-23 O\n\nUp O\nto O\n100,000 O\ntonnes O\nof O\ncopper O\nheld O\nin O\nShanghai B-LOC\nbonded O\nwarehouses O\n, O\nconfounding O\nthe O\nworld O\nmarket O\nas O\nto O\nits O\nsource O\nand O\nultimate O\nfate O\n, O\nprobably O\nbelongs O\nto O\nChina B-LOC\n's O\nstrategic O\nstate O\nreserve O\n, O\nindustry O\nsources O\nsaid O\non O\nFriday O\n. O\n\nAround O\n40,000 O\ntonnes O\nof O\nthe O\ncopper O\nhave O\nalready O\nbeen O\nmoved O\nto O\nwarehouses O\nnear O\nthe O\nnorthern O\nport O\nof O\nYingkou B-LOC\n, O\nwhere O\nsome O\nof O\nthe O\nstrategic O\nstockpile O\nwas O\nstored O\n, O\nthey O\nsaid O\n. O\n\nJust O\nwho O\nowns O\nthe O\ncopper O\nis O\na O\nquestion O\nthat O\nhas O\nkept O\ntraders O\nand O\nindustry O\nanalysts O\nguessing O\nsince O\nthe O\nmetal O\nwas O\nchannelled O\ninto O\nShanghai B-LOC\nby O\nthe O\nChina B-ORG\nNational I-ORG\nNonferrous I-ORG\nMetals I-ORG\nImport I-ORG\nand I-ORG\nExport I-ORG\nCorp I-ORG\n( O\nCNIEC B-ORG\n) O\nin O\nJune O\nand O\nJuly O\n. O\n\nIt O\nwas O\nunclear O\nwhether O\nor O\nnot O\nthe O\n40,000 O\ntonnes O\nhad O\ncleared O\ncustoms O\n-- O\nwhich O\nwould O\nprovide O\nsome O\nconcrete O\nindication O\nthat O\nthe O\nstrategic O\nreserve O\n, O\nadministered O\ndirectly O\nby O\nthe O\ncentral O\ngovernment O\n's O\nState B-ORG\nPlanning I-ORG\nCommission I-ORG\n, O\nowned O\nthe O\ncopper O\n. O\n\nTraders O\nhave O\nsaid O\nthe O\nreserve O\ncould O\nnegotiate O\nconcessions O\non O\nduties O\n-- O\nthree O\npercent O\nimport O\ntax O\nand O\n17 O\npercent O\nvalue-added O\ntax O\n-- O\nthat O\nmade O\nthe O\ncopper O\nprohibitively O\nexpensive O\notherwise O\n. O\n\nBut O\none O\nsource O\n, O\nthe O\nhead O\nof O\na O\nHong B-LOC\nKong I-LOC\ntrading O\nhouse O\n, O\nsaid O\nit O\nmade O\nno O\ndifference O\nif O\nthe O\ncopper O\nwas O\ncustoms O\ncleared O\nor O\nnot O\n. O\n\n\" O\nIf O\nthey O\nspend O\nall O\nthis O\nmoney O\nmoving O\nthe O\ncopper O\nto O\nYingkou B-LOC\n, O\nit O\nwill O\nbe O\nsitting O\nthere O\nfor O\nyears O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nOnce O\nit O\narrives O\nin O\nYingkou B-LOC\n, O\nit O\nis O\nsubject O\nto O\nmonitoring O\nby O\nthe O\nState B-ORG\nPlanning I-ORG\nCommission I-ORG\n, O\nwhich O\nhas O\nto O\ngive O\npermission O\nfor O\nany O\nmore O\nmovement O\n; O\nit O\nis O\nout O\nof O\nthe O\nhands O\nof O\ntraders O\n, O\n\" O\nhe O\nsaid O\n. O\n\nMystery O\nhas O\nsurrounded O\nthe O\nShanghai B-LOC\nstockpile O\nin O\nrecent O\nmonths O\n, O\nwith O\ntraders O\nunsure O\nnot O\nonly O\nof O\nwho O\nowns O\nit O\n, O\nbut O\nof O\nits O\nexact O\nsize O\nand O\nwhat O\nits O\nowner O\nplanned O\nto O\ndo O\nwith O\nit O\n. O\n\nTrading O\nsources O\ngenerally O\nagreed O\nit O\nwould O\nbe O\ncost-effective O\nto O\ntake O\nthe O\ncopper O\nback O\ninto O\na O\ndepleted O\ncentral O\nreserve O\nas O\nit O\nhad O\nalready O\nserved O\nits O\npurpose O\nin O\ntaking O\nadvantage O\nof O\nlong-term O\nbackwardation O\non O\nthe O\nLondon B-ORG\nMetal I-ORG\nExchange I-ORG\n( O\nLME B-ORG\n) O\n. O\n\nA O\nbackwardation O\noccurs O\nwhen O\nthe O\nspot O\nprice O\nof O\na O\nmetal O\nis O\nhigher O\nthan O\nthe O\nforward O\nprice O\n. O\n\nCNIEC B-ORG\nlent O\naround O\n85,000 O\ntonnes O\nof O\ncopper O\nonto O\nthe O\nLME B-ORG\nbetween O\nApril O\nand O\nJune O\n1995 O\non O\nbehalf O\nof O\nthe O\nstate O\nreserve O\n, O\nrunning O\nthe O\nstate O\nstockpile O\ndown O\nto O\n115,000 O\ntonnes O\nfrom O\n200,000 O\ntonnes O\npreviously O\n. O\n\nTraders O\nin O\nAsia B-LOC\nsaid O\nCNIEC B-ORG\ncould O\nwell O\nhave O\nlent O\nit O\nto O\nthe O\nmarket O\nat O\naround O\nUS$ B-MISC\n2,700 O\na O\ntonne O\n, O\nand O\nthen O\npaid O\nsomewhere O\nbetween O\n$ O\n2,200 O\nand O\n$ O\n2,400 O\na O\ntonne O\nwhen O\nit O\nstarted O\ntaking O\nthe O\nmetal O\nback O\nearlier O\nthis O\nyear O\n. O\n\nThis O\nwould O\nhave O\ncleared O\nCNIEC B-ORG\na O\nhealthy O\nprofit O\n, O\nwhich O\ncould O\nthen O\nhave O\nbeen O\nused O\nto O\nfinance O\nstorage O\nand O\nother O\ncosts O\n. O\n\nWord O\nthat O\nCNIEC B-ORG\nhad O\noffered O\nthe O\ncopper O\nto O\nEuropean B-MISC\ntrading O\nhouses O\nin O\na O\nseries O\nof O\nsecret O\nmeetings O\nunnerved O\nan O\nalready O\njittery O\nmarket O\n. O\n\nIndustry O\nanalysts O\nBloomsbury B-ORG\nMinerals I-ORG\nEconomics I-ORG\n( O\nBME B-ORG\n) O\nsaid O\non O\nWednesday O\nthe O\nmotivation O\nof O\nthe O\nowners O\nof O\nthe O\n85,000 O\ntonnes O\n, O\n\" O\nwhoever O\nthey O\nare O\n, O\nis O\nthe O\nmost O\nimportant O\nshort-term O\nfundamental O\n\" O\nin O\nan O\nalready O\ntight O\nworld O\nmarket O\n. O\n\nBME B-ORG\nrepeated O\nin O\nits O\nlatest O\nreview O\nrumours O\nof O\ninvolvement O\nby O\nSumitomo B-ORG\nCorp I-ORG\n, O\nwith O\nCNIEC B-ORG\nsaid O\nto O\nbe O\nhelping O\nthe O\nJapanese B-MISC\ntrader O\nunload O\nits O\ncopper O\npositions O\nafter O\nit O\nrevealed O\nin O\nJune O\nlosses O\nof O\n$ O\n1.8 O\nbillion O\nin O\na O\ndecade O\nof O\nunauthorised O\ndeals O\n. O\n\nSumitomo B-ORG\nand O\nCNIEC B-ORG\nhave O\nmade O\nno O\ncomments O\non O\nthe O\ntalk O\nand O\nChinese B-MISC\ntraders O\nsaid O\nthey O\nknow O\nnothing O\nof O\nsuch O\nan O\narrangement O\n. O\n\nTraders O\nin O\nShanghai B-LOC\nsaid O\non O\nThursday O\nthey O\nwere O\nunaware O\nof O\nmovements O\nout O\nof O\nthe O\nShanghai B-LOC\nbonded O\nwarehouses O\n. O\n\nThey O\nreported O\nmore O\narrivals O\nthat O\nwere O\nprobably O\nspot O\npurchases O\n. O\n\nThey O\nalso O\nexpressed O\nconcern O\nthat O\nthe O\ntonnage O\nin O\nbonded O\nwarehouses O\nwould O\nmove O\nonto O\nthe O\ndomestic O\nmarket O\n. O\n\nBut O\nthese O\nconcerns O\nwere O\nirrelevant O\n, O\na O\nSingapore B-LOC\ntrader O\nsaid O\n, O\ndespite O\na O\nforecast O\nthat O\ndomestic O\nChinese B-MISC\ncopper O\ndemand O\ncould O\nhit O\none O\nmillion O\ntonnes O\nthis O\nyear O\n. O\n\nAs O\nwith O\nmany O\ncommodities O\n, O\n\" O\nthere O\nis O\na O\ndesire O\n( O\nby O\nthe O\nChinese B-MISC\ngovernment O\n) O\nto O\nkeep O\na O\nstockpile O\nof O\nthe O\nmetal O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nYou O\ndo O\nn't O\nkeep O\nit O\nto O\nhelp O\nindustry O\n, O\nyou O\nkeep O\nit O\nin O\ncase O\nof O\nemergency O\n. O\n\" O\n\n-- O\nHong B-LOC\nKong I-LOC\nnewsroom O\n( O\n852 O\n) O\n2843-6470 O\n\n-DOCSTART- O\n\nCompanion B-ORG\nMarble I-ORG\nposts O\n1st O\nfinal O\nresult O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-23 O\n\nYear O\nended O\nMarch O\n31 O\n\n( O\nin O\nmillion O\nHK$ B-MISC\nunless O\nstated O\n) O\n\nShr O\n( O\nH.K. B-LOC\ncents O\n) O\n14.0 O\n\nDividend O\n( O\nH.K. B-LOC\ncents O\n) O\nnil O\n\nExceptional O\nitems O\nnil O\n\nNet O\n56.06 O\n\nTurnover O\n531.52 O\n\nCompany O\nname O\nCompanion B-ORG\nMarble I-ORG\n( O\nHoldings B-ORG\n) O\nLtd B-ORG\n\nBooks O\nclose O\nN O\n/ O\nA O\n\nDividend O\npayable O\nN O\n/ O\nA O\n\nNOTE O\n- O\nMarble O\nand O\ngranite O\nproducts O\ndistributor O\nCompanion B-ORG\nMarble I-ORG\n, O\na O\nspinoff O\nof O\nconstruction O\nmaterials O\nconcern O\nCompanion B-ORG\nBuilding I-ORG\nMaterial I-ORG\n( O\nHoldings B-ORG\n) O\nLtd B-ORG\n, O\nwas O\nlisted O\non O\nthe O\nStock B-ORG\nExchange I-ORG\non O\nApril O\n25 O\n, O\n1996 O\n. O\n\n-- O\nHong B-ORG\nKong I-ORG\nNews I-ORG\nRoom I-ORG\n( O\n852 O\n) O\n2843 O\n6368 O\n\n-DOCSTART- O\n\nSoftbank B-ORG\nto O\nprocure O\n$ O\n900 O\nmln O\nvia O\nforex O\nby O\nSept O\n5 O\n. O\n\nTOKYO B-LOC\n1996-08-23 O\n\nSoftbank B-ORG\nCorp I-ORG\nsaid O\non O\nFriday O\nthat O\nit O\nwould O\nprocure O\n$ O\n900 O\nmillion O\nthrough O\nthe O\nforeign O\nexchange O\nmarket O\nby O\nSeptember O\n5 O\nas O\npart O\nof O\nits O\nacquisition O\nof O\nU.S. B-LOC\nfirm O\n, O\nKingston B-ORG\nTechnology I-ORG\nCo I-ORG\n. O\n\n\" O\nIt O\nis O\nin O\nthe O\ncontract O\nthat O\nwe O\npay O\n( O\nKingston B-ORG\n) O\n$ O\n900 O\nmillion O\nby O\nSeptember O\n5 O\n, O\n\" O\nhe O\nsaid O\n, O\nadding O\nthat O\nSoftbank B-ORG\nhad O\nalready O\nstarted O\nmaking O\nforward O\ntransactions O\nto O\nbuy O\ndollars O\n. O\n\nOn O\nAugust O\n15 O\n, O\ncomputer O\nsoftware O\nretailer O\nSoftbank B-ORG\nsaid O\nit O\nwould O\nbuy O\n80 O\npercent O\nof O\nKingston B-ORG\n, O\nthe O\nworld O\n's O\nlargest O\nmaker O\nof O\nmemory O\nboards O\n, O\nfor O\nabout O\n$ O\n1.5 O\nbillion O\nin O\nthe O\nlatest O\nin O\na O\nseries O\nof O\nhigh-profile O\nacquisitions O\nit O\nhas O\nmade O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\n-DOCSTART- O\n\nShanghai B-ORG\nPost I-ORG\nand I-ORG\nTelecomm I-ORG\nnet O\ndown O\n. O\n\nSHANGHAI B-LOC\n1996-08-23 O\n\nHalf-year O\nended O\nJune O\n30 O\n, O\n1996 O\n\n( O\nin O\nmillions O\nof O\nyuan O\nunless O\nstated O\n) O\n\nTurnover O\n115.259 O\nvs O\n123.157 O\n\nNet O\nprofit O\n20.318 O\nvs O\n22.828 O\n\nNet O\nasset O\nper O\nshare O\n3.02 O\nyuan O\n( O\nno O\ncomparative O\nfigure O\n) O\n\nEarnings O\nper O\nshare O\n0.14 O\nyuan O\n( O\nno O\ncomparative O\nfigure O\n) O\n\nCompany O\nname O\n: O\nShanghai B-ORG\nPosts I-ORG\nand I-ORG\nTelecommunications I-ORG\nEquipment I-ORG\nCo I-ORG\n\nNote O\n: O\nthe O\nfigures O\nwere O\nunaudited O\n. O\n\n-DOCSTART- O\n\nPromodes B-ORG\nset O\nto O\nsell O\nGerman B-MISC\nassets O\n- O\npaper O\n. O\n\nPARIS B-LOC\n1996-08-23 O\n\nGerman B-MISC\nretailer O\nPromodes B-ORG\nis O\nin O\nadvanced O\ntalks O\nabout O\nselling O\nits O\nGerman B-MISC\nassets O\nand O\nthe O\nretailer O\n's O\nboard O\nmight O\ndecide O\nas O\nsoon O\nas O\nTuesday O\nto O\nsell O\nthe O\nassets O\nto O\nSpar B-ORG\nAG I-ORG\n, O\nLes B-ORG\nEchos I-ORG\nnewspaper O\nsaid O\non O\nFriday O\n. O\n\nIt O\nsaid O\ninvestment O\nbank O\nRothschild B-ORG\n& I-ORG\nCie I-ORG\nwas O\nan O\nintermediary O\nin O\nthe O\ntalks O\nand O\nadded O\nthat O\nunlisted O\nGerman B-MISC\nretailers O\nMetro B-ORG\n, O\nRewe B-ORG\nand O\nLidl B-ORG\nwere O\nalso O\nstill O\nin O\ndiscussions O\n. O\n\nPromodes B-ORG\nhas O\nin O\nGermany B-LOC\nits O\nPromo O\nhypermarket O\nunit O\nwith O\n36 O\nContinent O\nsuperstores O\n, O\nwhich O\nis O\n1995 O\ngenerated O\n4.7 O\npercent O\nof O\ntotal O\nPromodes B-ORG\nsales O\n. O\n\nThe O\nFrench B-MISC\ngroup O\nentered O\nthe O\nGerman B-MISC\nmarket O\nin O\n1990 O\n, O\nbuying O\n\nIn O\nJune O\n, O\nPromodes B-ORG\nsigned O\nan O\noutline O\nagreement O\nto O\nsell O\nits O\nSpecia B-ORG\nunit O\n-- O\nwhich O\nruns O\n100 O\nDia B-ORG\nstores O\nin O\nFrance B-LOC\n-- O\nto O\nGermany B-LOC\n's O\nAldi B-ORG\n. O\n\nPromodes B-ORG\nwas O\nnot O\nimmediately O\navailable O\nfor O\ncomment O\n. O\n\n-- O\nParis B-LOC\nnewsroom O\n+33 O\n1 O\n4221 O\n5452 O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nIreland B-LOC\n- O\nAugust O\n23 O\n. O\n\nDUBLIN B-LOC\n1996-08-23 O\n\nFollowing O\nare O\nhighlights O\nof O\nstories O\nin O\nthe O\nIrish B-MISC\npress O\non O\nFriday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nIRISH B-ORG\nINDEPENDENT I-ORG\n\n- O\nIreland B-LOC\n's O\nbiggest O\nmortgage O\nlender O\nIrish B-ORG\nPermanent I-ORG\nended O\nweeks O\nof O\nstalemate O\nwhen O\nit O\nannounced O\nit O\nwas O\nincreasing O\nits O\nmortgage O\nlending O\nrate O\nby O\na O\nquarter O\nof O\na O\npercentage O\npoint O\n. O\n\n- O\nTwo O\ninvestors O\nwho O\nclaim O\nto O\nbe O\nowed O\nnearly O\none O\nmillion O\nIrish B-MISC\npounds O\nby O\nfund O\nmanager O\nTony B-PER\nTaylor I-PER\nbelieve O\nthey O\nmay O\nhave O\nlost O\ntheir O\nmoney O\n. O\n\n- O\nA O\nsecond O\nJapanese B-MISC\ntrawler O\nwas O\nunder O\narrest O\non O\nThursday O\nnight O\nas O\nthe O\nIrish B-ORG\nNavy I-ORG\nand O\nAir B-ORG\nCorps I-ORG\ncontinued O\na O\ncat O\nand O\nmouse O\ngame O\nwith O\nup O\nto O\n40 O\nvessels O\noff O\nthe O\nIrish B-MISC\ncoast O\n. O\n\n- O\nThe O\nIrish B-ORG\nDepartment I-ORG\nof I-ORG\nEnterprise I-ORG\nand I-ORG\nEmployment I-ORG\nhas O\nwidened O\nits O\nprobe O\ninto O\nTaylor B-ORG\nAsset I-ORG\nManagers I-ORG\nto O\ninclude O\nthe O\ninvestigation O\nof O\ninvestments O\nof O\n10 O\nmore O\ninvestors O\n. O\n\n- O\nIrish B-MISC\nexploration O\ncompany O\nIvernia B-ORG\nand O\nits O\nSouth B-MISC\nAfrican I-MISC\npartner O\nMinorco B-ORG\nhave O\nreceived O\nplanning O\npermission O\nfrom O\nthe O\nlocal O\ncounty O\ncouncil O\nfor O\na O\nmajor O\nlead O\nand O\nzinc O\nmine O\nat O\nLisheen B-LOC\n, O\nCounty B-LOC\nTipperary I-LOC\n. O\n\n- O\nBuilding O\nmaterials O\nfirm O\nCRH B-ORG\nrefused O\nto O\ncomment O\non O\nreports O\nthat O\nit O\nis O\nabout O\nto O\npay O\n180 O\nmillion O\npounds O\nstering O\nfor O\nU.S. B-LOC\nstone O\nand O\nconcrete O\nbusiness O\nTilcon B-ORG\nInc I-ORG\n. O\n\nIRISH B-ORG\nTIMES I-ORG\n\n- O\nMortgage O\nlending O\nrates O\nare O\non O\nthe O\nway O\nup O\nwith O\nbanks O\nand O\nbuilding O\nsocieties O\npoised O\nto O\nadd O\naround O\na O\nquarter O\nof O\na O\npercentage O\npoint O\nto O\ntheir O\nmain O\nvariable O\nrates O\nof O\ninterest O\n. O\n\n- O\nMembers O\nof O\na O\nCounty B-LOC\nAntrim I-LOC\nProtestant O\nfamily O\nwho O\nwere O\ndriven O\ninto O\nexile O\nby O\nby O\nloyalist O\nparamilitaries O\ntwo O\nyears O\nago O\nreturned O\nyesterday O\nto O\nlive O\nin O\nNorthern B-LOC\nIreland I-LOC\nin O\ndefiance O\nof O\nthe O\nthreat O\nhanging O\nover O\nthem O\n. O\n\n- O\nTalks O\nwill O\nresume O\nnext O\nTuesday O\nin O\nan O\nattempt O\nto O\navoid O\na O\nmajor O\nstrike O\nin O\nIrish B-MISC\nretail O\nchain O\nDunnes B-ORG\nStores I-ORG\n. O\n\n- O\nTop O\ndealers O\nin O\nthe O\nLondon B-LOC\noffice O\nof O\nU.S. B-LOC\nbankers O\nMerrill B-ORG\nLynch I-ORG\nare O\ntransferring O\nto O\nDublin B-LOC\n. O\n\n- O\nThe O\nIrish B-MISC\nplastics O\nindustry O\ncalled O\non O\nthe O\ngovernment O\nto O\nsupport O\nincineration O\nto O\ndeal O\nwith O\nplastics O\nnot O\nsuitable O\nfor O\nrecycling O\n. O\n\n-DOCSTART- O\n\nFord B-ORG\nChina I-ORG\nJV O\nposts O\n77 O\npercent O\nnet O\ndrop O\nin O\nH1 O\n96 O\n. O\n\nSHANGHAI B-LOC\n1996-08-24 O\n\nA O\nChinese B-MISC\ntruck O\nmaker O\nin O\nwhich O\nFord B-ORG\nMotor I-ORG\nCo I-ORG\nhas O\na O\n20 O\npercent O\nstake O\nsaid O\nit O\nposted O\na O\n77 O\npercent O\ndrop O\nin O\npost-tax O\nprofits O\nin O\nthe O\nfirst O\nhalf O\nof O\n1996 O\n. O\n\nJiangling B-ORG\nMotors I-ORG\nCorp I-ORG\n, O\nin O\na O\nstatement O\nin O\nSaturday O\n's O\nedition O\nof O\nthe O\nChina B-ORG\nSecurities I-ORG\nnewspaper O\n, O\nsaid O\nnet O\nprofit O\nin O\nthe O\nperiod O\nwas O\n3.385 O\nmillion O\nyuan O\n, O\ndown O\nfrom O\n14.956 O\nmillion O\nin O\nthe O\nsame O\n1995 O\nperiod O\n. O\n\nTurnover O\nfell O\nto O\n937.891 O\nmillion O\nyuan O\nfrom O\n1.215 O\nbillion O\n, O\nwhile O\nnet O\nassets O\nper O\nshare O\nwere O\n1.88 O\nyuan O\n, O\nunchanged O\n, O\nand O\nearnings O\nper O\nshare O\nfell O\nto O\n0.005 O\nyuan O\nfrom O\n0.02 O\nyuan O\n, O\nthe O\nstatement O\nsaid O\n. O\n\nIn O\nthe O\nfirst O\nhalf O\n, O\nthe O\ncompany O\nsaid O\nit O\nproduced O\n8,333 O\nvehicles O\nand O\nsold O\n9,018 O\n, O\nbut O\nit O\ndid O\nnot O\nexplain O\nthe O\ndifference O\n. O\n\nIt O\nblamed O\nthe O\ndrop O\nin O\nprofits O\non O\na O\nweak O\nvehicle O\nmarket O\nand O\nsaid O\nas O\nits O\nengine O\nplant O\nhad O\nonly O\njust O\nstarted O\ntrial O\nproduction O\n, O\nthe O\ncompany O\n's O\nresults O\nwould O\nnot O\nimprove O\nin O\nthe O\nshort-term O\n. O\n\nFord B-ORG\nowns O\n138.643 O\nmillion O\nshares O\nin O\nthe O\nfirm O\n. O\n\nThe O\nmajority O\nshareholder O\n, O\nwith O\n51 O\npercent O\n, O\nor O\n353.24 O\nmillion O\nshares O\n, O\nis O\nJiangling B-ORG\nMotors I-ORG\nGroup I-ORG\n. O\n\nThe O\ncompany O\n, O\nin O\nthe O\nsouthern O\nprovince O\nof O\nJiangxi B-LOC\n, O\nhad O\nabout O\neight O\npercent O\nof O\nChina B-LOC\n's O\nlight O\ntruck O\nmarket O\nin O\n1994 O\n. O\n\n( O\n$ O\n1 O\n= O\n8.3 O\nyuan O\n) O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nHAMLET B-MISC\nCUP I-MISC\n. O\n\nCOMMACK B-LOC\n, O\nNew B-LOC\nYork I-LOC\n1996-08-24 O\n\nResults O\nfrom O\nthe O\n\nWaldbaum B-MISC\nHamlet I-MISC\nCup I-MISC\ntennis O\ntournament O\non O\nSaturday O\n( O\nprefix O\n\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nSemifinals O\n: O\n\nMartin B-PER\nDamm I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nAdrian B-PER\nVoinea I-PER\n( O\nRomania B-LOC\n) O\n5-7 O\n\n7-5 O\n7-5 O\n\n5 O\n- O\nAndrei B-PER\nMedvedev I-PER\n( O\nUkraine B-LOC\n) O\nbeat O\nKarol B-PER\nKucera I-PER\n( O\nSlovakia B-LOC\n) O\n7-6 O\n\n( O\n7-0 O\n) O\n6-3 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nTOSHIBA B-MISC\nCLASSIC I-MISC\n. O\n\nCARLSBAD B-LOC\n, O\nCalif. B-LOC\n1996-08-24 O\n\nResults O\nfrom O\nthe O\n$ O\n450,000 O\nToshiba B-MISC\nClassic I-MISC\ntennis O\ntournament O\non O\nSaturday O\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nSemifinals O\n: O\n\n1 O\n- O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\n( O\nSpain B-LOC\n) O\nbeat O\n3 O\n- O\nJana B-PER\nNovotna I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n1-6 O\n, O\n6-2 O\n6-3 O\n\n4 O\n- O\nKimiko B-PER\nDate I-PER\n( O\nJapan B-LOC\n) O\nbeat O\n2 O\n- O\nConchita B-PER\nMartinez I-PER\n( O\nSpain B-LOC\n) O\n6-2 O\n7-5 O\n. O\n\n-DOCSTART- O\n\nRALLYING O\n- O\nKANKKUNEN B-PER\nIN O\nCOMMAND O\nAS O\nMCRAE B-PER\nROLLS O\nOUT O\n. O\n\nJYVASKYLA B-LOC\n, O\nFinland B-LOC\n1996-08-24 O\n\nFinland B-LOC\n's O\nJuha B-PER\nKankkunen I-PER\nproduced O\nan O\nimpressive O\nperformance O\nin O\nhis O\nToyota B-ORG\non O\nSaturday O\nto O\nopen O\nup O\na O\n37 O\nseconds O\nlead O\nafter O\nsix O\nstages O\nof O\nthe O\n1,000 B-MISC\nLakes I-MISC\nRally I-MISC\n, O\nsixth O\nround O\nof O\nthe O\nworld O\nchampionship O\n. O\n\nOn O\na O\nweekend O\novershadowed O\nby O\nFriday O\n's O\nfatal O\naccident O\n, O\nfour O\ntimes O\nworld O\nchampion O\nKankunnen B-PER\nemerged O\nfrom O\nthe O\nfirst O\nfive O\nof O\nSaturday O\n's O\n10 O\nstages O\nwith O\na O\ncommanding O\nadvantage O\nover O\nhis O\ncountry O\n's O\nlatest O\nprospect O\n, O\nMarcus B-PER\nGronholm I-PER\n, O\nalso O\nin O\na O\nToyota B-ORG\n. O\n\nWorld O\nchampionship O\nleader O\nTommi B-PER\nMakinen I-PER\nin O\nhis O\nMitsubishi B-ORG\nwas O\nthird O\nbut O\ncurrent O\nworld O\nchampion O\nColin B-PER\nMcRae I-PER\nended O\na O\nbad O\nweek O\nby O\ncrashing O\nout O\n. O\n\nAfter O\nbeing O\nfined O\n$ O\n250,000 O\nby O\nthe O\nsports O\ngoverning O\nbody O\non O\nTuesday O\n, O\nthe O\nBritish B-MISC\ndriver O\nrolled O\nhis O\nSubaru B-ORG\n6.5 O\nkm O\ninto O\nstage O\nsix O\n. O\n\nHe O\nand O\nco-driver O\nDerek B-PER\nRinger I-PER\nwere O\nunhurt O\nbut O\nteam O\nboss O\nDavid B-PER\nRichards I-PER\nwas O\nfurious O\nwith O\nthem O\n. O\n\n\" O\nIt O\n's O\nnot O\nunfortunate O\n, O\nit O\n's O\nincompetent O\n, O\n\" O\nhe O\ndeclared O\n. O\n\nKankkunen B-PER\nhas O\nset O\nan O\nastonishing O\npace O\nfor O\na O\ndriver O\nwho O\nhas O\nnot O\nrallied O\nfor O\nthree O\nmonths O\n. O\n\n\" O\nIf O\nyou O\ndo O\na O\nlot O\nof O\nsomething O\n, O\nsometimes O\nit O\n's O\ngood O\nto O\nhave O\na O\nbreak O\n. O\n\nIt O\n's O\nnot O\nbad O\nfor O\nan O\nold O\nman O\n! O\n\" O\n\nsaid O\nthe O\n37-year-old O\nveteran O\n. O\n\nFord B-ORG\nhad O\na O\npoor O\nmorning O\nwith O\nSpaniard B-MISC\nCarlos B-PER\nSainz I-PER\nlosing O\n90 O\nseconds O\nthrough O\nturbo O\ntrouble O\nwhile O\nBelgian B-MISC\nBruno B-PER\nThiry I-PER\ndropped O\nfour O\nminutes O\nwhen O\na O\ntransmission O\nshaft O\nsnapped O\n. O\n\n-DOCSTART- O\n\nMOTOR O\nRACING O\n- O\nBELGIAN B-MISC\nGRAND I-MISC\nPRIX I-MISC\nGRID O\nPOSITIONS O\n. O\n\nSPA-FRANCORCHAMPS B-LOC\n, O\nBelgium B-LOC\n1996-08-24 O\n\nGrid O\npositions O\n\nfor O\nSunday O\n's O\nBelgian B-MISC\nGrand I-MISC\nPrix I-MISC\nmotor O\nrace O\nafter O\nfinal O\n\nqualifying O\non O\nSaturday O\n: O\n\n1. O\nJacques B-PER\nVilleneuve I-PER\n( O\nCanada B-LOC\n) O\nWilliams B-ORG\n1 O\nminute O\n50.574 O\n\nseconds O\n( O\naverage O\nspeed O\n226.859 O\nkph O\n) O\n\n2. O\nDamon B-PER\nHill I-PER\n( O\nBritain B-LOC\n) O\nWilliams B-ORG\n1:50.980 O\n\n3. O\nMichael B-PER\nSchumacher I-PER\n( O\nGermany B-LOC\n) O\nFerrari B-ORG\n1:51.778 O\n\n4. O\nDavid B-PER\nCoulthard I-PER\n( O\nBritain B-LOC\n) O\nMcLaren B-ORG\n1:51.884 O\n\n5. O\nGerhard B-PER\nBerger I-PER\n( O\nAustria B-LOC\n) O\nBenetton B-ORG\n1:51.960 O\n\n6. O\nMika B-PER\nHakkinen I-PER\n( O\nFinland B-LOC\n) O\nMcLaren B-ORG\n1:52.318 O\n\n7. O\nJean B-PER\nAlesi I-PER\n( O\nFrance B-LOC\n) O\nBenetton B-ORG\n1:52.354 O\n\n8. O\nMartin B-PER\nBrundle I-PER\n( O\nBritain B-LOC\n) O\nJordan B-ORG\n1:52.977 O\n\n9. O\nEddie B-PER\nIrvine I-PER\n( O\nBritain B-LOC\n) O\nFerrari B-ORG\n1:53.043 O\n\n10. O\nRubens B-PER\nBarrichello I-PER\n( O\nBrazil B-LOC\n) O\nJordan B-ORG\n1:53.152 O\n\nAdd O\ngrid O\n: O\n\n11. O\nHeinz-Harald B-PER\nFrentzen I-PER\n( O\nGermany B-LOC\n) O\nSauber B-ORG\n1:53.199 O\n\n12. O\nJohnny B-PER\nHerbert I-PER\n( O\nBritain B-LOC\n) O\nSauber B-ORG\n1:53.993 O\n\n13. O\nMika B-PER\nSalo I-PER\n( O\nFinland B-LOC\n) O\nTyrrell B-ORG\n1:54.095 O\n\n14. O\nOlivier B-PER\nPanis I-PER\n( O\nFrance B-LOC\n) O\nLigier B-ORG\n1:54.220 O\n\n15. O\nPedro B-PER\nDiniz I-PER\n( O\nBrazil B-LOC\n) O\nLigier B-ORG\n1:54.700 O\n\n16. O\nJos B-PER\nVerstappen I-PER\n( O\nNetherlands B-LOC\n) O\nArrows B-ORG\n1:55.150 O\n\n17. O\nUkyo B-PER\nKatayama I-PER\n( O\nJapan B-LOC\n) O\nTyrrell B-ORG\n1:55.371 O\n\n18. O\nRicardo B-PER\nRosset I-PER\n( O\nBrazil B-LOC\n) O\nArrows B-ORG\n1:56.286 O\n\n19. O\nPedro B-PER\nLamy I-PER\n( O\nPortugal B-LOC\n) O\nMinardi B-ORG\n1:56.830 O\n\nDid O\nnot O\nqualify O\n( O\ntimes O\ndid O\nnot O\nmeet O\nqualifying O\nstandard O\n) O\n: O\n\n20. O\nGiovanni B-PER\nLavaggi I-PER\n( O\nItaly B-LOC\n) O\nMinardi B-ORG\n1:58.579 O\n\n-DOCSTART- O\n\nRALLYING O\n- O\nBELGIAN B-MISC\nSPECTATOR O\nDIES O\nIN O\nFINNISH B-MISC\nRALLY O\n. O\n\nJYVASKYLA B-LOC\n, O\nFinland B-LOC\n1996-08-24 O\n\nA O\nBelgian B-MISC\nman O\ndied O\nand O\n31 O\npeople O\nwere O\ninjured O\nafter O\nan O\naccident O\nin O\nFriday O\n's O\nopening O\nphase O\nof O\nthe O\nworld O\nchampionship O\n1,000 B-MISC\nLakes I-MISC\nRally I-MISC\n. O\n\nThe O\nunnamed O\nvictim O\ndied O\nduring O\nthe O\nnight O\n, O\na O\nhospital O\nspokesman O\nsaid O\non O\nSaturday O\n. O\n\nDanish B-MISC\ndriver O\nKarsten B-PER\nRichardt I-PER\nhad O\nploughed O\ninto O\nthe O\ncrowd O\nduring O\nthe O\ntwo-kilometre O\nfirst O\nstage O\nheld O\nin O\nthe O\nhost O\ncity O\nof O\nJyvaskyla B-LOC\n. O\n\nRichardt B-PER\n's O\nMitsubishi B-ORG\nskidded O\ndown O\nan O\nescape O\nroad O\nand O\nploughed O\ninto O\na O\ncordoned-off O\narea O\nfor O\nspectators O\n. O\n\nA O\nsecond O\nBelgian B-MISC\nwas O\nalso O\nseriously O\ninjured O\nbut O\nthe O\nhospital O\nspokesman O\nsaid O\nhis O\nlife O\nwas O\nnot O\nin O\ndanger O\n. O\n\nThe O\nstage O\nwas O\nsuspended O\nbut O\nthe O\nfour-day O\nrally O\nresumed O\non O\nSaturday O\n. O\n\nA O\nwoman O\nwas O\nkilled O\nbefore O\nlast O\nyear O\n's O\nevent O\nwhen O\nshe O\nwalked O\nin O\nfront O\nof O\na O\ncar O\npractising O\non O\nthe O\ncourse O\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nTOSHIBA B-MISC\nCLASSIC I-MISC\n. O\n\nCARLSBAD B-LOC\n, O\nCalifornia B-LOC\n1996-08-24 O\n\nResults O\nfrom O\nthe O\n\n$ O\n450,000 O\nToshiba B-MISC\nClassic I-MISC\ntennis O\ntournament O\non O\nFriday O\n( O\nprefix O\n\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nQuarterfinals O\n: O\n\n1 O\n- O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nKatarina B-PER\nStudenikova I-PER\n\n( O\nSlovakia B-LOC\n) O\n6-3 O\n6-3 O\n\n3 O\n- O\nJana B-PER\nNovotna I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nSandrine B-PER\nTestud I-PER\n( O\nFrance B-LOC\n) O\n\n2-6 O\n7-6 O\n( O\n7-4 O\n) O\n6-3 O\n. O\n\n4 O\n- O\nKimiko B-PER\nDate I-PER\n( O\nJapan B-LOC\n) O\nbeat O\n5 O\n- O\nGabriela B-PER\nSabatini I-PER\n( O\nArgentina B-LOC\n) O\n\n6-4 O\n6-1 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nHAMLET B-MISC\nCUP I-MISC\n. O\n\nCOMMACK B-LOC\n, O\nNew B-LOC\nYork I-LOC\n1996-08-23 O\n\nResults O\nfrom O\nthe O\n\nWaldbaum B-MISC\nHamlet I-MISC\nCup I-MISC\ntennis O\ntournament O\non O\nFriday O\n( O\nprefix O\nnumber O\n\ndenotes O\nseeding O\n) O\n: O\n\nQuarterfinals O\n: O\n\nAdrian B-PER\nVoinea I-PER\n( O\nRomania B-LOC\n) O\nbeat O\nThomas B-PER\nJohansson I-PER\n( O\nSweden B-LOC\n) O\n7-6 O\n\n( O\n7-4 O\n) O\n6-2 O\n\n5 O\n- O\nAndrei B-PER\nMedvedev I-PER\n( O\nUkraine B-LOC\n) O\nbeat O\nJonathan B-PER\nStark I-PER\n( O\nU.S. B-LOC\n) O\n7-6 O\n\n( O\n7-4 O\n) O\n4-6 O\n6-3 O\n\nMartin B-PER\nDamm I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nMichael B-PER\nJoyce I-PER\n( O\nU.S. B-LOC\n) O\n5-7 O\n\n6-2 O\n6-3 O\n\nKarol B-PER\nKucera I-PER\n( O\nSlovakia B-LOC\n) O\nbeat O\n1 O\n- O\nMichael B-PER\nChang I-PER\n( O\nU.S. B-LOC\n) O\n6-4 O\n6-4 O\n\n-DOCSTART- O\n\nGOLF B-LOC\n- O\nTHUNDERSTORMS O\nFORCE O\nSUSPENSION O\nOF O\nSECOND O\nROUND O\nIN O\nAKRON B-LOC\n. O\n\nAKRON B-LOC\n, O\nOhio B-LOC\n1996-08-23 O\n\nThunderstorms O\nforced O\nthe O\nsuspension O\nof O\nthe O\nWorld B-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\nafter O\njust O\nfive O\nplayers O\nin O\nthe O\n43-man O\nfield O\nhad O\ncompleted O\nthe O\nsecond O\nround O\non O\nFriday O\n. O\n\nPlay O\ninitially O\nwas O\ninterrupted O\nfor O\nmore O\nthan O\n3-1/2 O\nhours O\nbefore O\nresuming O\nfor O\ntwo O\nhours O\n. O\n\nBut O\nplay O\nwas O\nfinally O\nsuspended O\nfor O\nthe O\nday O\nwhen O\nthe O\nstorm O\ncontinued O\n. O\n\nThe O\n38 O\nplayers O\nare O\nschedeled O\nto O\nresume O\ntheir O\nrounds O\non O\nSaturday O\nmorning O\nbefore O\nthe O\nthird O\nround O\nbegins O\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nSCORES O\nAT O\nWORLD B-MISC\nSERIES I-MISC\nOF I-MISC\nGOLF I-MISC\n. O\n\nAKRON B-LOC\n, O\nOhio B-LOC\n1996-08-23 O\n\nScores O\nfrom O\nthe O\n$ O\n2.1 O\n\nmillion O\nNEC B-MISC\nWorld I-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\nafter O\nthe O\nsecond O\nround O\nwas O\n\nsuspended O\ndue O\nto O\nrain O\non O\nFriday O\nwith O\n38 O\nof O\nthe O\n43 O\nplayers O\nyet O\n\nto O\nfinish O\ntheir O\nrounds O\non O\nthe O\n7,149 O\nyard O\n, O\npar O\n70 O\nFirestone B-LOC\nC.C I-LOC\n\ncourse O\n( O\nplayers O\nU.S. B-LOC\nunless O\nnoted O\n) O\n: O\n\n- O\n5 O\nPaul B-PER\nGoydos I-PER\nthrough O\n2 O\nholes O\n\n- O\n5 O\nBilly B-PER\nMayfair I-PER\nthrough O\n2 O\n\n- O\n4 O\nGreg B-PER\nNorman I-PER\n( O\nAustralia B-LOC\n) O\nthrough O\n8 O\n\n- O\n4 O\nHidemichi B-PER\nTanaka I-PER\n( O\nJapan B-LOC\n) O\nthrough O\n3 O\n\n- O\n3 O\nSteve B-PER\nStricker I-PER\nthrough O\n3 O\n\n- O\n2 O\nPhil B-PER\nMickelson I-PER\nthrough O\n7 O\n\n- O\n2 O\nMark B-PER\nBrooks I-PER\nthrough O\n3 O\n\n- O\n1 O\nHal B-PER\nSutton I-PER\nthrough O\n11 O\n\n- O\n1 O\nJohn B-PER\nCook I-PER\nthrough O\n5 O\n\n- O\n1 O\nTim B-PER\nHerron I-PER\nthrough O\n4 O\n\n- O\n1 O\nJustin B-PER\nLeonard I-PER\nthrough O\n3 O\n\n0 O\nSteve B-PER\nJones I-PER\nthrough O\n7 O\n\n0 O\nNick B-PER\nFaldo I-PER\n( O\nBritain B-LOC\n) O\nthrough O\n5 O\n\n0 O\nDavis B-PER\nLove I-PER\nthrough O\n5 O\n\n+1 O\nFred B-PER\nCouples I-PER\nthrough O\n15 O\n\n+1 O\nFred B-PER\nFunk I-PER\nthrough O\n9 O\n\n+1 O\nScott B-PER\nHoch I-PER\nthrough O\n9 O\n\n+1 O\nErnie B-PER\nEls I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nthrough O\n8 O\n\n+2 O\nD.A. B-PER\nWeibring I-PER\nthrough O\n12 O\n\n+2 O\nClarence B-PER\nRose I-PER\nthrough O\n9 O\n\n+2 O\nDuffy B-PER\nWaldorf I-PER\nthrough O\n4 O\n\n+3 O\nJim B-PER\nFuryk I-PER\nthrough O\n16 O\n\n+3 O\nCorey B-PER\nPavin I-PER\nthrough O\n14 O\n\n+3 O\nCraig B-PER\nStadler I-PER\nthrough O\n14 O\n\n+3 O\nBrad B-PER\nBryant I-PER\nthrough O\n12 O\n\n+3 O\nTom B-PER\nLehman I-PER\nthrough O\n11 O\n\n+3 O\nSven B-PER\nStruver I-PER\n( O\nGermany B-LOC\n) O\nthrough O\n10 O\n\n+3 O\nAlexander B-PER\nCejka I-PER\n( O\nGermany B-LOC\n) O\nthrough O\n10 O\n\n+3 O\nAnders B-PER\nForsbrand I-PER\n( O\nSweden B-LOC\n) O\nthrough O\n5 O\n\n+4 O\nWillie B-PER\nWood I-PER\nthrough O\n17 O\n\n+4 O\nCostantino B-PER\nRocca I-PER\n( O\nItaly B-LOC\n) O\nthrough O\n15 O\n\n+4 O\nStewart B-PER\nGinn I-PER\n( O\nAustralia B-LOC\n) O\nthrough O\n13 O\n\n+5 O\nWayne B-PER\nWestner I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n77 O\n68 O\n\n+5 O\nSigeki B-PER\nMaruyama I-PER\n( O\nJapan B-LOC\n) O\nthrough O\n17 O\n\n+5 O\nMark B-PER\nO'Meara I-PER\nthrough O\n15 O\n\n+5 O\nLoren B-PER\nRoberts I-PER\nthrough O\n9 O\n\n+6 O\nScott B-PER\nMcCarron I-PER\n76 O\n70 O\n\n+7 O\nSatoshi B-PER\nHigashi I-PER\n( O\nJapan B-LOC\n) O\nthrough O\n16 O\n\n+7 O\nPaul B-PER\nStankowski I-PER\nthrough O\n15 O\n\n+8 O\nCraig B-PER\nParry I-PER\n( O\nAustralia B-LOC\n) O\nthrough O\n13 O\n\n+9 O\nTom B-PER\nWatson I-PER\n79 O\n70 O\n\n+11 O\nSeiki B-PER\nOkuda I-PER\n( O\nJapan B-LOC\n) O\n81 O\n70 O\n( O\nthrough O\n18 O\n) O\n\n+11 O\nSteve B-PER\nSchneiter I-PER\n77 O\n74 O\n) O\nthrough O\n18 O\n) O\n\n-DOCSTART- O\n\nRUGBY B-MISC\nLEAGUE I-MISC\n- O\nEUROPEAN B-MISC\nSUPER I-MISC\nLEAGUE I-MISC\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-24 O\n\nResults O\nof O\nEuropean B-MISC\nSuper I-MISC\nLeague I-MISC\n\nrugby O\nleague O\nmatches O\non O\nSaturday O\n: O\n\nParis B-ORG\n14 O\nBradford B-ORG\n27 O\n\nWigan B-ORG\n78 O\nWorkington B-ORG\n4 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\npoints O\n\nfor O\n, O\nagainst O\n, O\ntotal O\npoints O\n) O\n: O\n\nWigan B-ORG\n22 O\n19 O\n1 O\n2 O\n902 O\n326 O\n39 O\n\nSt B-ORG\nHelens I-ORG\n21 O\n19 O\n0 O\n2 O\n884 O\n441 O\n38 O\n\nBradford B-ORG\n22 O\n17 O\n0 O\n5 O\n767 O\n409 O\n34 O\n\nWarrington B-ORG\n21 O\n12 O\n0 O\n9 O\n555 O\n499 O\n24 O\n\nLondon B-ORG\n21 O\n11 O\n1 O\n9 O\n555 O\n462 O\n23 O\n\nSheffield B-ORG\n21 O\n10 O\n0 O\n11 O\n574 O\n696 O\n20 O\n\nHalifax B-ORG\n21 O\n9 O\n1 O\n11 O\n603 O\n552 O\n19 O\n\nCastleford B-ORG\n21 O\n9 O\n0 O\n12 O\n548 O\n543 O\n18 O\n\nOldham B-ORG\n21 O\n8 O\n1 O\n12 O\n439 O\n656 O\n17 O\n\nLeeds B-ORG\n21 O\n6 O\n0 O\n15 O\n531 O\n681 O\n12 O\n\nParis B-ORG\n22 O\n3 O\n1 O\n18 O\n398 O\n795 O\n7 O\n\nWorkington B-ORG\n22 O\n2 O\n1 O\n19 O\n325 O\n1021 O\n5 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nESSEX B-ORG\nPOISED O\nTO O\nSTEP O\nUP O\nTITLE O\nCHALLENGE O\n. O\n\nLONDON B-LOC\n1996-08-24 O\n\nEssex B-ORG\nare O\nset O\nto O\nstep O\nup O\ntheir O\nEnglish B-MISC\ncounty O\nchampionship O\nchallenge O\nwith O\na O\nfifth O\nconsecutive O\nvictory O\nafter O\nnew-ball O\npair O\nNeil B-PER\nWilliams I-PER\nand O\nMark B-PER\nIlott I-PER\nsent O\nGloucestershire B-ORG\nreeling O\non O\nSaturday O\n. O\n\nWilliams B-PER\nseized O\ntwo O\nwickets O\nin O\ntwo O\ndeliveries O\nand O\nleft-armer O\nIlott B-PER\nalso O\ncaptured O\ntwo O\nas O\nGloucestershire B-ORG\n, O\n252 O\nbehind O\non O\nfirst O\ninnings O\n, O\nslumped O\nto O\n27 O\nfor O\nfour O\nat O\nthe O\nclose O\non O\nthe O\nthird O\nday O\nof O\nthe O\nfour-day O\ngame O\nat O\nColchester B-LOC\n. O\n\nEssex B-ORG\n, O\nwho O\nstarted O\nthe O\ncurrent O\nround O\nof O\nmatches O\nin O\nfifth O\nplace O\n20 O\npoints O\nbehind O\nleaders O\nDerbyshire B-ORG\nwith O\na O\ngame O\nin O\nhand O\n, O\ncould O\ngo O\ntop O\nif O\nthey O\ncomplete O\nvictory O\non O\nMonday O\n's O\nlast O\nday O\nand O\nother O\nresults O\nfavour O\nthem O\n. O\n\nWilliams B-PER\nthrust O\nEssex B-ORG\non O\ncourse O\nfor O\nsuccess O\nby O\ndispatching O\nMatt B-PER\nWindows I-PER\nand O\nAndrew B-PER\nSymonds I-PER\nin O\nhis O\nsecond O\nover O\n, O\nbefore O\nIlott B-PER\nremoved O\nDominic B-PER\nHewson I-PER\nand O\nTim B-PER\nHancock I-PER\nto O\nreduce O\nGloucestershire B-ORG\nto O\n17 O\nfor O\nfour O\nat O\none O\nstage O\n. O\n\nThe O\nvisitors O\nhad O\nstarted O\nthe O\nday O\noptimistically O\nby O\nsending O\nback O\nformer O\nEngland B-LOC\ncaptain O\nGraham B-PER\nGooch I-PER\nwhen O\nhe O\nadded O\njust O\nsix O\nto O\nhis O\novernight O\n105 O\n, O\nbut O\nEssex B-ORG\nwent O\non O\nto O\nmake O\n532 O\nfor O\neight O\nbefore O\ndeclaring O\n. O\n\nCaptain O\nPaul B-PER\nPrichard I-PER\nplundered O\n88 O\nfrom O\n73 O\ndeliveries O\n, O\nhitting O\n15 O\nfours O\nand O\none O\nsix O\n. O\n\nSecond-placed O\nKent B-ORG\nwere O\nfrustrated O\nby O\nrain O\nwhich O\nprevented O\nany O\nplay O\nat O\nCardiff B-LOC\n, O\nwhere O\nthey O\nhave O\nreached O\n255 O\nfor O\nthree O\nin O\ntheir O\nfirst O\ninnings O\nagainst O\nGlamorgan B-ORG\n, O\nwhile O\nthird-placed O\nSurrey B-ORG\nare O\nfacing O\nan O\nuphill O\ntask O\nagainst O\nNottinghamshire B-ORG\n. O\n\nSurrey B-ORG\nslipped O\nto O\n88 O\nfor O\nfour O\nin O\nreply O\nto O\nNotts B-ORG\n' O\ncommanding O\nfirst O\ninnings O\nof O\n446 O\nfor O\nnine O\ndeclared O\nat O\nTrent B-LOC\nBridge I-LOC\n, O\nbefore O\nAlistair B-PER\nBrown I-PER\nstruck O\na O\n55-ball O\nhalf-century O\n. O\n\nBrown B-PER\n's O\n56 O\nnot O\nout O\n, O\ncontaining O\neight O\nfours O\nand O\nthree O\nsixes O\n, O\nlifted O\nSurrey B-ORG\nto O\n128 O\nfor O\nfour O\non O\na O\nrain-curtailed O\nday O\n. O\n\nFourth-placed O\nLeicestershire B-ORG\nhad O\nHampshire B-ORG\non O\nthe O\nropes O\nat O\nLeicester B-LOC\nbefore O\nrain O\nintervened O\n. O\n\nPace O\ntrio O\nDavid B-PER\nMillns I-PER\n( O\n2-24 O\n) O\n, O\nGordon B-PER\nParsons I-PER\n( O\n3-20 O\n) O\nand O\nVince B-PER\nWells I-PER\n( O\n2-19 O\n) O\nhad O\nHampshire B-ORG\nreeling O\nat O\n81 O\nfor O\nseven O\nin O\nreply O\nto O\nthe O\nhome O\ncounty O\n's O\nfirst O\ninnings O\nof O\n353 O\n. O\n\nYorkshire B-ORG\nrekindled O\ntheir O\ntitle O\nhopes O\nafter O\nthree O\nsuccessive O\ndefeats O\nby O\ntaking O\nthe O\nupper O\nhand O\nagainst O\narch-rivals O\nLancashire B-ORG\nat O\nOld B-LOC\nTrafford I-LOC\n. O\n\nFacing O\nYorkshire B-ORG\n's O\n529 O\nfor O\neight O\ndeclared O\n, O\nLancashire B-ORG\nwere O\nforced O\nto O\nfollow O\non O\n206 O\nbehind O\nafter O\nbeing O\nbowled O\nout O\nfor O\n323 O\n, O\npaceman O\nDarren B-PER\nGough I-PER\npolishing O\noff O\nthe O\ninnings O\nwith O\na O\nburst O\nof O\nthree O\nwickets O\nfor O\none O\nrun O\nin O\n17 O\ndeliveries O\n. O\n\nLancashire B-ORG\nthen O\nreached O\n210 O\nfor O\nfive O\nat O\nthe O\nclose O\n-- O\njust O\nfour O\nahead O\n-- O\nafter O\nNeil B-PER\nFairbrother I-PER\nhit O\n55 O\nin O\n60 O\nballs O\nto O\nadd O\nto O\nhis O\nfirst O\ninnings O\nof O\n86 O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nV O\nPAKISTAN B-LOC\nFINAL O\nTEST O\nSCOREBOARD O\n. O\n\nLONDON B-LOC\n1996-08-24 O\n\nScoreboard O\non O\nthe O\nthird O\nday O\nof O\nthe O\n\nthird O\nand O\nfinal O\ntest O\nbetween O\nEngland B-LOC\nand O\nPakistan B-LOC\nat O\nThe B-LOC\nOval I-LOC\non O\n\nSaturday O\n: O\n\nEngland B-LOC\nfirst O\ninnings O\n326 O\n( O\nJ. B-PER\nCrawley I-PER\n106 O\n, O\nG. B-PER\nThorpe I-PER\n54 O\n; O\nWaqar B-PER\n\nYounis B-PER\n4-95 O\n) O\n\nPakistan B-LOC\nfirst O\ninnings O\n( O\novernight O\n229-1 O\n) O\n\nSaeed B-PER\nAnwar I-PER\nc O\nCroft B-PER\nb O\nCork B-PER\n176 O\n\nAamir B-PER\nSohail I-PER\nc O\nCork B-PER\nb O\nCroft B-PER\n46 O\n\nIjaz B-PER\nAhmed I-PER\nc O\nStewart B-PER\nb O\nMullally B-PER\n61 O\n\nInzamam-ul-Haq B-PER\nc O\nHussain B-PER\nb O\nMullally B-PER\n35 O\n\nSalim B-PER\nMalik I-PER\nnot O\nout O\n2 O\n\nAsif B-PER\nMujtaba I-PER\nnot O\nout O\n1 O\n\nExtras O\n( O\nb-4 O\nlb-3 O\nnb-11 O\n) O\n18 O\n\nTotal O\n( O\nfor O\nfour O\nwickets O\n) O\n339 O\n\nFall O\nof O\nwickets O\n: O\n1-106 O\n2-239 O\n3-334 O\n4-334 O\n\nTo O\nbat O\n: O\nWasim B-PER\nAkram I-PER\n, O\nMoin B-PER\nKhan I-PER\n, O\nMushtaq B-PER\nAhmed I-PER\n, O\nWaqar B-PER\nYounis I-PER\n, O\n\nMohammad B-PER\nAkam I-PER\n\nBowling O\n( O\nto O\ndate O\n) O\n: O\nLewis B-PER\n12-1-76-0 O\n, O\nMullally B-PER\n22-6-56-2 O\n, O\n\nCroft B-PER\n29-6-64-1 O\n, O\nCork B-PER\n14.3-4-45-1 O\n, O\nSalisbury B-PER\n17-0-91-0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLISH B-MISC\nCOUNTY I-MISC\nCHAMPIONSHIP I-MISC\nSCORES O\n. O\n\nLONDON B-LOC\n1996-08-24 O\n\nClose O\nof O\nplay O\nscores O\nin O\nfour-day O\n\nEnglish B-MISC\nCounty I-MISC\nChampionship I-MISC\ncricket O\nmatches O\non O\nSaturday O\n: O\n\nFinal O\nday O\n\nAt O\nWeston-super-Mare B-LOC\n: O\nMatch O\nabandoned O\nas O\na O\ndraw O\n- O\nrain O\n. O\n\nDurham B-ORG\n326 O\n( O\nD. B-PER\nCox I-PER\n95 O\nnot O\nout O\n, O\nS. B-PER\nCampbell I-PER\n69 O\n; O\nG. B-PER\nRose I-PER\n7-73 O\n) O\n. O\n\nSomerset B-ORG\n298-6 O\n( O\nM. B-PER\nLathwell I-PER\n85 O\n, O\nR. B-PER\nHarden I-PER\n65 O\n) O\n. O\n\nSomerset B-ORG\n9 O\npoints O\n, O\n\nDurham B-ORG\n8 O\n. O\n\nThird O\nday O\n\nAt O\nColchester B-LOC\n: O\nGloucestershire B-ORG\n280 O\nand O\n27-4 O\n. O\n\nEssex B-ORG\n532-8 O\n\ndeclared O\n( O\nG. B-PER\nGooch I-PER\n111 O\n, O\nR. B-PER\nIrani I-PER\n91 O\n, O\nP. B-PER\nPrichard I-PER\n88 O\n, O\nD. B-PER\nRobinson I-PER\n72 O\n; O\n\nM. B-PER\nAlleyne I-PER\n4-80 O\n) O\n. O\n\nAt O\nCardiff B-LOC\n: O\nKent B-ORG\n255-3 O\n( O\nD. B-PER\nFulton I-PER\n64 O\n, O\nM. B-PER\nWalker I-PER\n59 O\n, O\nC. B-PER\nHooper I-PER\n\n52 O\nnot O\nout O\n) O\nv O\nGlamorgan B-ORG\n. O\n\nNo O\nplay O\n- O\nrain O\n. O\n\nAt O\nLeicester B-LOC\n: O\nLeicestershire B-ORG\n353 O\n( O\nP. B-PER\nSimmons I-PER\n108 O\n, O\nP. B-PER\nNixon I-PER\n67 O\n; O\n\nS. B-PER\nRenshaw I-PER\n4-56 O\n, O\nJ. B-PER\nBovill I-PER\n4-102 O\n) O\n. O\n\nHampshire B-ORG\n81-7 O\n. O\n\nAt O\nNorthampton B-LOC\n: O\nSussex B-ORG\n389 O\nand O\n112 O\n( O\nC. B-PER\nAmbrose I-PER\n6-26 O\n) O\n. O\n\nNorthamptonshire B-ORG\n361 O\n( O\nK. B-PER\nCurran I-PER\n117 O\n, O\nD. B-PER\nRipley I-PER\n66 O\nnot O\nout O\n) O\nand O\n\n42-3 O\n. O\n\nAt O\nTrent B-LOC\nBridge I-LOC\n: O\nNottinghamshire B-ORG\n446-9 O\ndeclared O\n( O\nG. B-PER\nArcher I-PER\n\n143 O\n, O\nM. B-PER\nDowman I-PER\n107 O\n, O\nW. B-PER\nNoon I-PER\n57 O\n; O\nB. B-PER\nJulian I-PER\n4-104 O\n) O\n. O\n\nSurrey B-ORG\n128-4 O\n\n( O\nA. B-PER\nBrown I-PER\n56 O\nnot O\nout O\n) O\n. O\n\nAt O\nWorcester B-LOC\n: O\nWarwickshire B-ORG\n310 O\n( O\nA. B-PER\nGiles I-PER\n83 O\n, O\nT. B-PER\nMunton I-PER\n54 O\nnot O\n\nout O\n, O\nW. B-PER\nKhan I-PER\n52 O\n; O\nR. B-PER\nIllingworth I-PER\n4-54 O\n, O\nS. B-PER\nLampitt I-PER\n4-90 O\n) O\n. O\n\nWorcestershire B-ORG\n205-9 O\n( O\nK. B-PER\nSpiring I-PER\n52 O\n) O\n. O\n\nAt O\nHeadingley B-LOC\n: O\nYorkshire B-ORG\n529-8 O\ndeclared O\n( O\nC. B-PER\nWhite I-PER\n181 O\n, O\n\nR. B-PER\nBlakey I-PER\n109 O\nnot O\nout O\n, O\nM. B-PER\nMoxon I-PER\n66 O\n, O\nM. B-PER\nVaughan I-PER\n57 O\n) O\n. O\n\nLancashire B-ORG\n323 O\n\n( O\nN. B-PER\nFairbrother I-PER\n86 O\n, O\nM. B-PER\nWatkinson I-PER\n64 O\n; O\nD. B-PER\nGough I-PER\n4-53 O\n) O\nand O\n210-5 O\n\n( O\nN. B-PER\nSpeak I-PER\n65 O\nnot O\nout O\n, O\nN. B-PER\nFairbrother I-PER\n55 O\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSCOTTISH B-MISC\nLEAGUE O\nRESULTS O\n. O\n\nGLASGOW B-LOC\n1996-08-24 O\n\nResults O\nof O\nScottish B-MISC\nleague O\nsoccer O\n\nmatches O\non O\nSaturday O\n: O\n\nPremier O\ndivision O\n\nHibernian B-ORG\n0 O\nDunfermline B-ORG\n0 O\n\nKilmarnock B-ORG\n1 O\nCeltic B-ORG\n3 O\n\nRaith B-ORG\n0 O\nMotherwell B-ORG\n3 O\n\nRangers B-ORG\n1 O\nDundee B-ORG\nUnited I-ORG\n0 O\n\nPlaying O\nSunday O\n: O\n\nAberdeen B-ORG\nv O\nHearts B-ORG\n\nDivision O\none O\n\nAirdrieonians B-ORG\n0 O\nEast B-ORG\nFife I-ORG\n0 O\n\nClydebank B-ORG\n1 O\nStirling B-ORG\n0 O\n\nDundee B-ORG\n2 O\nGreenock B-ORG\nMorton I-ORG\n1 O\n\nFalkirk B-ORG\n1 O\nPartick B-ORG\n0 O\n\nSt B-ORG\nMirren I-ORG\n0 O\nSt B-ORG\nJohnstone I-ORG\n3 O\n\nDivision O\ntwo O\n\nBerwick B-ORG\n0 O\nStenhousemuir B-ORG\n6 O\n\nBrechin B-ORG\n1 O\nAyr B-ORG\n1 O\n\nHamilton B-ORG\n2 O\nClyde B-ORG\n0 O\n\nQueen B-ORG\nof I-ORG\nthe I-ORG\nSouth I-ORG\n2 O\nDumbarton B-ORG\n1 O\n\nStranraer B-ORG\n1 O\nLivingston B-ORG\n2 O\n\nDivision O\nthree O\n\nAlloa B-ORG\n1 O\nArbroath B-ORG\n1 O\n\nCowdenbeath B-ORG\n1 O\nMonstrose B-ORG\n0 O\n\nForfar B-ORG\n3 O\nInverness B-ORG\n1 O\n\nRoss B-ORG\nCounty I-ORG\n1 O\nQueen B-ORG\n's I-ORG\nPark I-ORG\n2 O\n\nPlayed O\nFriday O\n: O\n\nEast B-ORG\nStirling I-ORG\n0 O\nAlbion B-ORG\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nOUT-OF-SORTS O\nNEWCASTLE B-ORG\nCRASH O\n2-1 O\nAT O\nHOME O\n. O\n\nLONDON B-LOC\n1996-08-24 O\n\nNewcastle B-ORG\n's O\nearly O\nseason O\nteething O\nproblems O\ncontinued O\non O\nSaturday O\nwhen O\nthey O\nlost O\n2-1 O\nat O\nhome O\nto O\npremier O\nleague O\npacesetters O\nSheffield B-ORG\nWednesday I-ORG\n. O\n\nEngland B-LOC\nstriker O\nAlan B-PER\nShearer I-PER\ngave O\nKevin B-PER\nKeegan I-PER\n's O\ntalent-laden O\nside O\nthe O\nlead O\nfrom O\nthe O\npenalty O\nspot O\nafter O\n13 O\nminutes O\nafter O\nWednesday O\n's O\nYugoslav B-MISC\nDejan B-PER\nStefanovic I-PER\npulled O\ndown O\nColombian B-MISC\nforward O\nFaustino B-PER\nAsprilla I-PER\n. O\n\nBut O\ntwo O\nminutes O\nlater O\nWednesday B-ORG\nequalised O\nthrough O\nPeter B-PER\nAtherton I-PER\n, O\nwho O\nfound O\nspace O\nin O\nthe O\npenalty O\narea O\nto O\nmeet O\nMark B-PER\nPembridge I-PER\n's O\nfree O\nkick O\nwith O\na O\nprecise O\nglancing O\nheader O\n. O\n\nGuy B-PER\nWhittingham I-PER\nstole O\nthree O\npoints O\nfor O\nthe O\nYorkshire B-ORG\nside O\nwith O\na O\ngoal O\n10 O\nminutes O\nfrom O\ntime O\n. O\n\nTo O\nadd O\nto O\nNewcastle B-ORG\n's O\nmisery O\n, O\nEngland B-LOC\nstriker O\nLes B-PER\nFerdinand I-PER\nwas O\nstretchered O\noff O\nin O\nthe O\nsecond O\nhalf O\n. O\n\nWednesday B-ORG\n, O\nwho O\nescaped O\nrelegation O\non O\nthe O\nfinal O\nday O\nof O\nlast O\nseason O\n, O\nhave O\nnow O\nwon O\ntheir O\nfirst O\nthree O\ngames O\nof O\nthe O\nseason O\n. O\n\nElsewhere O\n, O\ntitle O\nhopefuls O\nLiverpool B-ORG\nwere O\nheld O\n0-0 O\nat O\nhome O\nby O\nnewly-promoted O\nSunderland B-ORG\n, O\nand O\nin O\nLondon B-LOC\n, O\nthe O\ntie O\nbetween O\nTottenham B-ORG\nHotspur I-ORG\nand O\nEverton B-ORG\nalso O\nended O\ngoaless O\n. O\n\nFrenchman B-MISC\nFrank B-PER\nLeBoeuf I-PER\nand O\nItalian B-MISC\nGianluca B-PER\nVialli I-PER\nscored O\ntheir O\nfirst O\npremier O\nleague O\ngoals O\nas O\nChelsea B-ORG\nbeat O\nCoventry B-ORG\n2-0 O\n, O\nand O\nmanagerless O\nArsenal B-ORG\nwon O\nby O\nthe O\nsame O\nscoreline O\nat O\nLeicester B-LOC\n. O\n\nLast O\nseason O\n's O\nleague O\nand O\nCup B-MISC\nwinners O\nManchester B-ORG\nUnited I-ORG\nhost O\n1995 O\nchampions O\nBlackburn B-ORG\non O\nSunday O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nLEAGUE O\nRESULTS O\n. O\n\nLONDON B-LOC\n1996-08-24 O\n\nResults O\nof O\nEnglish B-MISC\nleague O\nsoccer O\n\nmatches O\non O\nSaturday O\n: O\n\nPremier O\nleague O\n\nAston B-ORG\nVilla I-ORG\n2 O\nDerby B-ORG\n0 O\n\nChelsea B-ORG\n2 O\nCoventry B-ORG\n0 O\n\nLeicester B-ORG\n0 O\nArsenal B-ORG\n2 O\n\nLiverpool B-ORG\n0 O\nSunderland B-ORG\n0 O\n\nNewcastle B-ORG\n1 O\nSheffield B-ORG\nWednesday I-ORG\n2 O\n\nNottingham B-ORG\nForest I-ORG\n1 O\nMiddlesbrough B-ORG\n1 O\n\nTottenham B-ORG\n0 O\nEverton B-ORG\n0 O\n\nWest B-ORG\nHam I-ORG\n2 O\nSouthampton B-ORG\n1 O\n\nPlaying O\nSunday O\n: O\n\nManchester B-ORG\nUnited I-ORG\nv O\nBlackburn B-ORG\n\nPlaying O\nMonday O\n: O\n\nLeeds B-ORG\nv O\nWimbledon B-ORG\n\nDivision O\none O\n\nBolton B-ORG\n3 O\nNorwich B-ORG\n1 O\n\nCharlton B-ORG\n1 O\nWest B-ORG\nBromwich I-ORG\n1 O\n\nCrystal B-ORG\nPalace I-ORG\n3 O\nOldham B-ORG\n1 O\n\nIpswich B-ORG\n5 O\nReading B-ORG\n2 O\n\nOxford B-ORG\n5 O\nSouthend B-ORG\n0 O\n\nSheffield B-ORG\nUnited I-ORG\n4 O\nBirmingham B-ORG\n4 O\n\nStoke B-ORG\n2 O\nManchester B-ORG\nCity I-ORG\n1 O\n\nSwindon B-ORG\n1 O\nPort B-ORG\nVale I-ORG\n1 O\n\nWolverhampton B-ORG\n1 O\nBradford B-ORG\n0 O\n\nPlayed O\nFriday O\n: O\n\nPortsmouth B-ORG\n1 O\nQueen B-ORG\n's I-ORG\nPark I-ORG\nRangers I-ORG\n2 O\n\nTranmere B-ORG\n3 O\nGrimsby B-ORG\n2 O\n\nPlaying O\nSunday O\n: O\n\nBarnsley B-ORG\nv O\nHuddersfield B-ORG\n\nDivision O\ntwo O\n\nBrentford B-ORG\n3 O\nLuton B-ORG\n2 O\n\nBristol B-ORG\nCity I-ORG\nv O\nBlackpool B-ORG\nlate O\nkickoff O\n\nBurnley B-ORG\n2 O\nWalsall B-ORG\n1 O\n\nChesterfield B-ORG\n1 O\nBury B-ORG\n2 O\n\nPeterborough B-ORG\n2 O\nCrewe B-ORG\n2 O\n\nPreston B-ORG\n0 O\nBristol B-ORG\nRovers I-ORG\n0 O\n\nRotherham B-ORG\n1 O\nShrewsbury B-ORG\n2 O\n\nStockport B-ORG\n0 O\nNotts B-ORG\nCounty I-ORG\n0 O\n\nWatford B-ORG\n0 O\nMillwall B-ORG\n2 O\n\nWrexham B-ORG\n4 O\nPlymouth B-ORG\n4 O\n\nWycombe B-ORG\n1 O\nGillingham B-ORG\n1 O\n\nYork B-ORG\n1 O\nBournemouth B-ORG\n2 O\n\nDivision O\nthree O\n\nBarnet B-ORG\n1 O\nWigan B-ORG\n1 O\n\nCardiff B-ORG\n1 O\nBrighton B-ORG\n0 O\n\nCarlisle B-ORG\n0 O\nHull B-ORG\n0 O\n\nChester B-ORG\n1 O\nCambridge B-ORG\n1 O\n\nDarlington B-ORG\n4 O\nSwansea B-ORG\n1 O\n\nExeter B-ORG\n2 O\nScarborough B-ORG\n2 O\n\nHartlepool B-ORG\n2 O\nFulham B-ORG\n1 O\n\nHereford B-ORG\n1 O\nDoncaster B-ORG\n0 O\n\nLincoln B-ORG\n1 O\nLeyton B-ORG\nOrient I-ORG\n1 O\n\nNorthampton B-ORG\n3 O\nMansfield B-ORG\n0 O\n\nRochdale B-ORG\n0 O\nColchester B-ORG\n0 O\n\nScunthorpe B-ORG\n1 O\nTorquay B-ORG\n0 O\n\nAdd O\nDivision O\ntwo O\n\nBristol B-ORG\nCity I-ORG\n0 O\nBlackpool B-ORG\n1 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\n318-2 O\nV O\nENGLAND B-LOC\n-- O\nLUNCH O\n. O\n\nLONDON B-LOC\n1996-08-24 O\n\nPakistan B-LOC\nwere O\n318 O\nfor O\ntwo O\nat O\nlunch O\non O\nthe O\nthird O\nday O\nof O\nthe O\nthird O\nand O\nfinal O\ntest O\nat O\nThe B-LOC\nOval I-LOC\non O\nSaturday O\nin O\nreply O\nto O\nEngland B-LOC\n's O\n326 O\nall O\nout O\n. O\n\nScore O\n: O\nEngland B-LOC\n326 O\n( O\nJ. B-PER\nCrawley I-PER\n106 O\n, O\nG. B-PER\nThorpe I-PER\n54 O\n. O\n\nWaqar B-PER\nYounis I-PER\n4-95 O\n) O\n. O\n\nPakistan B-LOC\n318-2 O\n( O\nSaeed B-PER\nAnwar I-PER\n169 O\nnot O\nout O\n, O\nIjaz B-PER\nAhmed I-PER\n61 O\n) O\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nCANADIAN B-MISC\nOPEN I-MISC\n. O\n\nTORONTO B-LOC\n1996-08-23 O\n\nResults O\nfrom O\nthe O\nCanadian B-MISC\nOpen I-MISC\n\ntennis O\ntournament O\non O\nFriday O\n( O\nprefix O\nnumbers O\ndenotes O\nseedings O\n) O\n: O\n\nQuarterfinals O\n\n3 O\n- O\nWayne B-PER\nFerreira I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\n5 O\n- O\nThomas B-PER\nEnqvist I-PER\n\n( O\nSweden B-LOC\n) O\n7-5 O\n6-2 O\n\n4 O\n- O\nMarcelo B-PER\nRios I-PER\n( O\nChile B-LOC\n) O\nbeat O\nPatrick B-PER\nRafter I-PER\n( O\nAustralia B-LOC\n) O\n0-6 O\n\n7-6 O\n( O\n7-4 O\n) O\n6-1 O\n\n7 O\n- O\nTodd B-PER\nMartin I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAlex B-PER\nO'Brien I-PER\n( O\nU.S. B-LOC\n) O\n6-4 O\n6-4 O\n\nTodd B-PER\nWoodbridge I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nMark B-PER\nPhilippoussis I-PER\n\n( O\nAustralia B-LOC\n) O\n7-5 O\n6-4 O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nNEW B-LOC\nZEALAND I-LOC\nWIN O\nFIRST O\nSERIES O\nIN O\nSOUTH B-LOC\nAFRICA I-LOC\n. O\n\nPRETORIA B-LOC\n, O\nSouth B-LOC\nAfrica I-LOC\n1996-08-24 O\n\nNew B-LOC\nZealand I-LOC\nmade O\nhistory O\non O\nSaturday O\nwhen O\nthey O\ncompleted O\ntheir O\nfirst O\nseries O\nvictory O\nin O\nSouth B-LOC\nAfrica I-LOC\nwith O\na O\n33-26 O\nvictory O\nin O\nthe O\nsecond O\ntest O\n. O\n\nThe O\nwin O\ngave O\nthe O\nAll B-ORG\nBlacks I-ORG\nan O\nunbeatable O\n2-0 O\nlead O\nin O\nthe O\nthree-test O\nseries O\n. O\n\nEach O\nside O\nscored O\nthree O\ntries O\nand O\nthe O\nSpringboks B-ORG\noutscored O\nthe O\nAll B-ORG\nBlacks I-ORG\n15-12 O\nin O\nthe O\nsecond O\nhalf O\nbut O\nstill O\nsuffered O\na O\nfourth O\nsuccessive O\ndefeat O\nagainst O\ntheir O\nold O\nenemies O\n. O\n\nTwo O\ntries O\nfrom O\nwing O\nJeff B-PER\nWilson I-PER\nin O\nthe O\nfirst O\nquarter O\ngave O\nNew B-LOC\nZealand I-LOC\na O\n24-11 O\nlead O\nbefore O\ntries O\nfrom O\nflanker O\nRuben B-PER\nKruger I-PER\nand O\nscrum-half O\nJoost B-PER\nvan I-PER\nder I-PER\nWesthuizen I-PER\nin O\nthe O\nspace O\nof O\ntwo O\nminutes O\nnarrowed O\nthe O\ngap O\nto O\na O\nsingle O\npoint O\nat O\n23-24 O\n. O\n\nThe O\nSpringboks B-ORG\nwould O\nhave O\ngone O\nahead O\nhad O\nnot O\nfly-half O\nJoel B-PER\nStransky I-PER\n's O\nconversion O\nhit O\nan O\nupright O\nand O\nNew B-LOC\nZealand I-LOC\nonly O\nscrambled O\nto O\nsafety O\nthrough O\na O\nfine O\npenalty O\nfrom O\nreplacement O\nfly-half O\nJon B-PER\nPreston I-PER\nand O\na O\ndrop O\ngoal O\nby O\nnumber O\neight O\nZinzan B-PER\nBrooke I-PER\n. O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nNEW B-LOC\nZEALAND I-LOC\nDEFEAT O\nSOUTH B-LOC\nAFRICA I-LOC\n33-26 O\n. O\n\nPRETORIA B-LOC\n, O\nSouth B-LOC\nAfrica I-LOC\n1996-08-24 O\n\nNew B-LOC\nZealand I-LOC\nbeat O\nSouth B-LOC\nAfrica I-LOC\n33-26 O\n( O\nhalftime O\n21-11 O\n) O\nin O\nthe O\nsecond O\ntest O\non O\nSaturday O\n. O\n\nScorers O\n: O\n\nSouth B-LOC\nAfrica I-LOC\n- O\nTries O\n: O\nHannes B-PER\nStrydom I-PER\n, O\nRuben B-PER\nKruger I-PER\n, O\nJoost B-PER\nvan I-PER\nder I-PER\nWesthuizen I-PER\n. O\n\nPenalties O\n: O\nJoel B-PER\nStranksy I-PER\n( O\n3 O\n) O\n. O\n\nConversion O\n: O\nStranksy B-PER\n. O\n\nNew B-LOC\nZealand I-LOC\n- O\nTries O\n: O\nJeff B-PER\nWilson I-PER\n( O\n2 O\n) O\n, O\nZinzan B-PER\nBrooke I-PER\n. O\n\nPenalties O\n: O\nSimon B-PER\nCulhane I-PER\n, O\nJon B-PER\nPreston I-PER\n( O\n2 O\n) O\n. O\n\nConversions O\n: O\nCulhane B-PER\n( O\n3 O\n) O\n. O\n\nDrop O\ngoal O\n: O\nZinzan B-PER\nBrooke I-PER\n. O\n\nNew B-LOC\nZealand I-LOC\nlead O\nthe O\nthree-test O\nseries O\n2-0 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nYUGOSLAV B-MISC\nLEAGUE O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nBELGRADE B-LOC\n1996-08-24 O\n\nResults O\nof O\nYugoslav B-MISC\nleague O\n\nsoccer O\nmatches O\nplayed O\non O\nSaturday O\n: O\n\nDivision O\nA O\n\nCukaricki B-ORG\n0 O\nHajduk B-ORG\n2 O\n\nBecej B-ORG\n2 O\nBorac B-ORG\n0 O\n\nMladost B-ORG\n( I-ORG\nL I-ORG\n) I-ORG\n0 O\nZemun B-ORG\n0 O\n\nRad B-ORG\n1 O\nBuducnost B-ORG\n( I-ORG\nP I-ORG\n) I-ORG\n0 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nBecej B-ORG\n3 O\n2 O\n1 O\n0 O\n5 O\n1 O\n7 O\n\nPartizan B-ORG\n2 O\n2 O\n0 O\n0 O\n6 O\n2 O\n6 O\n\nVojvodina B-ORG\n2 O\n2 O\n0 O\n0 O\n4 O\n1 O\n6 O\n\nRed B-ORG\nStar I-ORG\n2 O\n2 O\n0 O\n0 O\n3 O\n1 O\n6 O\n\nMladost B-ORG\n( I-ORG\nL I-ORG\n) I-ORG\n3 O\n1 O\n1 O\n1 O\n6 O\n4 O\n4 O\n\nRad B-ORG\n3 O\n1 O\n1 O\n1 O\n2 O\n2 O\n4 O\n\nHajduk B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n3 O\n3 O\n\nCukaricki B-ORG\n3 O\n1 O\n0 O\n2 O\n5 O\n6 O\n3 O\n\nBuducnost B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n5 O\n3 O\n\nZemun B-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n3 O\n2 O\n\nProleter B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n4 O\n1 O\n\nBorac B-ORG\n3 O\n0 O\n0 O\n3 O\n0 O\n8 O\n0 O\n\nDivision O\nB O\n\nSutjeska B-ORG\n3 O\nSloboda B-ORG\n2 O\n\nLoznica B-ORG\n0 O\nObilic B-ORG\n1 O\n\nOFK B-ORG\nKikinda I-ORG\n1 O\nRadnicki B-ORG\n( I-ORG\nN I-ORG\n) I-ORG\n0 O\n\nSpartak B-ORG\n1 O\nBuducnost B-ORG\n( I-ORG\nV I-ORG\n) I-ORG\n2 O\n\nOFK B-ORG\nBeograd I-ORG\n2 O\nMladost B-ORG\n( I-ORG\nBJ I-ORG\n) I-ORG\n2 O\n\nStandings O\n: O\n\nObilic B-ORG\n3 O\n3 O\n0 O\n0 O\n8 O\n1 O\n9 O\n\nLoznica B-ORG\n3 O\n2 O\n0 O\n1 O\n7 O\n3 O\n6 O\n\nSutjeska B-ORG\n3 O\n2 O\n0 O\n1 O\n6 O\n3 O\n6 O\n\nOFK B-ORG\nKikinda I-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n1 O\n6 O\n\nBuducnost B-ORG\n( I-ORG\nV I-ORG\n) I-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n3 O\n6 O\n\nSpartak B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n3 O\n4 O\n\nZeleznik B-ORG\n2 O\n1 O\n0 O\n1 O\n4 O\n4 O\n3 O\n\nOFK B-ORG\nBeograd I-ORG\n3 O\n0 O\n3 O\n1 O\n4 O\n4 O\n3 O\n\nRadnicki B-ORG\n3 O\n1 O\n0 O\n2 O\n5 O\n6 O\n3 O\n\nSloboda B-ORG\n3 O\n0 O\n1 O\n2 O\n4 O\n8 O\n1 O\n\nMladost B-ORG\n( I-ORG\nBJ I-ORG\n) I-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n6 O\n1 O\n\nRudar B-ORG\n2 O\n0 O\n0 O\n2 O\n0 O\n6 O\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPOLISH B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n. O\n\nWARSAW B-LOC\n1996-08-24 O\n\nResults O\nof O\nPolish B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatches O\non O\nSaturday O\n: O\n\nAmica B-ORG\nWronki I-ORG\n3 O\nHutnik B-ORG\nKrakow I-ORG\n0 O\n\nSokol B-ORG\nTychy I-ORG\n5 O\nLech B-ORG\nPoznan I-ORG\n3 O\n\nRakow B-ORG\nCzestochowa I-ORG\n1 O\nStomil B-ORG\nOlsztyn I-ORG\n4 O\n\nWisla B-ORG\nKrakow I-ORG\n1 O\nGornik B-ORG\nZabrze I-ORG\n0 O\n\nSlask B-ORG\nWroclaw I-ORG\n3 O\nOdra B-ORG\nWodzislaw I-ORG\n1 O\n\nGKS B-ORG\nKatowice I-ORG\n1 O\nPolonia B-ORG\nWarsaw I-ORG\n0 O\n\nZaglebie B-ORG\nLubin I-ORG\n2 O\nLKS B-ORG\nLodz I-ORG\n1 O\n\nLegia B-ORG\nWarsaw I-ORG\n3 O\nGKS B-ORG\nBelchatow I-ORG\n2 O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nPHILIPPINE B-MISC\nPRO-LEAGUE O\nRESULTS O\n. O\n\nMANILA B-LOC\n1996-08-24 O\n\nResults O\nof O\nsemi-final O\nround O\ngames O\non O\nFriday O\nin O\nthe O\nPhilippine B-ORG\nBasketball I-ORG\nAssociation I-ORG\nsecond O\nconference O\n, O\nwhich O\nincludes O\nAmerican B-MISC\nplayers O\n: O\n\nAlaska B-ORG\nMilk I-ORG\nbeat O\nPurefoods B-ORG\nHotdogs I-ORG\n103-95 O\n( O\n34-48 O\nhalf-time O\n) O\n\nGinebra B-ORG\nSan I-ORG\nMiguel I-ORG\nbeat O\nShell B-ORG\n120-103 O\n( O\n65-56 O\n) O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nRESULTS O\nOF O\nS. B-MISC\nKOREAN I-MISC\nPRO-BASEBALL O\nGAMES O\n. O\n\nSEOUL B-LOC\n1996-08-24 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\n\npro-baseball O\ngames O\nplayed O\non O\nFriday O\n. O\n\nSamsung B-ORG\n13 O\nHyundai B-ORG\n3 O\n\nHaitai B-ORG\n5 O\nHanwha B-ORG\n4 O\n\nOB B-ORG\n4 O\nLotte B-ORG\n2 O\n\nSsangbangwool B-ORG\n1 O\nLG B-ORG\n0 O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nFriday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\ndrawn O\n, O\nlost O\n, O\nwinning O\npercentage O\n, O\ngames O\nbehind O\nfirst O\nplace O\n) O\n\nW O\nD O\nL O\nPCT O\nGB O\n\nHaitai B-ORG\n62 O\n2 O\n40 O\n.606 O\n- O\n\nSsangbangwool B-ORG\n56 O\n2 O\n47 O\n.543 O\n6 O\n1/2 O\n\nHanwha B-ORG\n55 O\n1 O\n47 O\n.539 O\n7 O\n\nHyundai B-ORG\n54 O\n5 O\n47 O\n.533 O\n7 O\n1/2 O\n\nSamsung B-ORG\n47 O\n5 O\n53 O\n.471 O\n14 O\n\nLotte B-ORG\n43 O\n5 O\n52 O\n.455 O\n15 O\n1/2 O\n\nLG B-ORG\n44 O\n5 O\n56 O\n.443 O\n17 O\n\nOB B-ORG\n40 O\n5 O\n59 O\n.407 O\n20 O\n1/2 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nFRIDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-24 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nFriday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n73 O\n54 O\n.575 O\n- O\n\nBALTIMORE B-ORG\n67 O\n60 O\n.528 O\n6 O\n\nBOSTON B-ORG\n64 O\n65 O\n.496 O\n10 O\n\nTORONTO B-ORG\n60 O\n69 O\n.465 O\n14 O\n\nDETROIT B-ORG\n46 O\n82 O\n.359 O\n27 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n76 O\n52 O\n.594 O\n- O\n\nCHICAGO B-ORG\n69 O\n61 O\n.531 O\n8 O\n\nMINNESOTA B-ORG\n64 O\n64 O\n.500 O\n12 O\n\nMILWAUKEE B-ORG\n61 O\n68 O\n.473 O\n15 O\n1/2 O\n\nKANSAS B-ORG\nCITY I-ORG\n58 O\n72 O\n.446 O\n19 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n74 O\n55 O\n.574 O\n- O\n\nSEATTLE B-ORG\n66 O\n61 O\n.520 O\n7 O\n\nOAKLAND B-ORG\n62 O\n69 O\n.473 O\n13 O\n\nCALIFORNIA B-ORG\n60 O\n68 O\n.469 O\n13 O\n1/2 O\n\nSATURDAY O\n, O\nAUGUST O\n24TH O\nSCHEDULE O\n\nSEATTLE B-ORG\nAT O\nBOSTON B-LOC\n\nMILWAUKEE B-ORG\nAT O\nCLEVELAND B-LOC\n\nCALIFORNIA B-ORG\nAT O\nBALTIMORE B-LOC\n\nTORONTO B-ORG\nAT O\nCHICAGO B-LOC\n\nOAKLAND B-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nDETROIT B-ORG\nAT O\nKANSAS B-LOC\nCITY I-LOC\n\nTEXAS B-ORG\nAT O\nMINNESOTA B-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n80 O\n47 O\n.630 O\n- O\n\nMONTREAL B-ORG\n69 O\n58 O\n.543 O\n11 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n70 O\n.457 O\n22 O\n\nFLORIDA B-ORG\n59 O\n70 O\n.457 O\n22 O\n\nPHILADELPHIA B-ORG\n53 O\n76 O\n.411 O\n28 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nST B-ORG\nLOUIS I-ORG\n68 O\n60 O\n.531 O\n- O\n\nHOUSTON B-ORG\n68 O\n61 O\n.527 O\n1/2 O\n\nCINCINNATI B-ORG\n64 O\n63 O\n.504 O\n3 O\n1/2 O\n\nCHICAGO B-ORG\n63 O\n63 O\n.500 O\n4 O\n\nPITTSBURGH B-ORG\n55 O\n73 O\n.430 O\n13 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n70 O\n60 O\n.538 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n68 O\n60 O\n.531 O\n1 O\n\nCOLORADO B-ORG\n66 O\n63 O\n.512 O\n3 O\n1/2 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n54 O\n72 O\n.429 O\n14 O\n\nSATURDAY O\n, O\nAUGUST O\n24TH O\nSCHEDULE O\n\nCHICAGO B-ORG\nAT O\nATLANTA B-LOC\n\nST B-ORG\nLOUIS I-ORG\nAT O\nHOUSTON B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nLOS B-LOC\nANGELES I-LOC\n\nMONTREAL B-ORG\nAT O\nSAN B-LOC\nFRANCISCO I-LOC\n\nCINCINNATI B-ORG\nAT O\nFLORIDA B-LOC\n\nPITTSBURGH B-ORG\nAT O\nCOLORADO B-LOC\n\nPHILADELPHIA B-ORG\nAT O\nSAN B-LOC\nDIEGO I-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nFRIDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-24 O\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\n\nBaseball O\ngames O\nplayed O\non O\nFriday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nAmerican B-MISC\nLeague I-MISC\n\nBOSTON B-ORG\n6 O\nSeattle B-ORG\n4 O\n\nMilwaukee B-ORG\n6 O\nCLEVELAND B-ORG\n5 O\n( O\n11 O\ninnings O\n) O\n\nCalifornia B-ORG\n2 O\nBALTIMORE B-ORG\n0 O\n\nNEW B-ORG\nYORK I-ORG\n5 O\nOakland B-ORG\n3 O\n\nToronto B-ORG\n4 O\nCHICAGO B-ORG\n2 O\n\nDetroit B-ORG\n3 O\nKANSAS B-ORG\nCITY I-ORG\n2 O\n\nMINNESOTA B-ORG\n9 O\nTexas B-ORG\n2 O\n\nNational B-MISC\nLeague I-MISC\n\nCincinnati B-ORG\n6 O\nFLORIDA B-ORG\n5 O\n( O\n1ST O\nGM O\n) O\n\nFLORIDA B-ORG\n8 O\nCincinnati B-ORG\n3 O\n( O\n2ND O\nGM O\n) O\n\nATLANTA B-ORG\n4 O\nChicago B-ORG\n3 O\n\nSt B-ORG\nLouis I-ORG\n1 O\nHOUSTON B-ORG\n0 O\n\nPittsburgh B-ORG\n5 O\nCOLORADO B-ORG\n3 O\n\nLOS B-ORG\nANGELES I-ORG\n7 O\nNew B-ORG\nYork I-ORG\n5 O\n\nPhiladelphia B-ORG\n7 O\nSAN B-ORG\nDIEGO I-ORG\n4 O\n\nMontreal B-ORG\n10 O\nSAN B-ORG\nFRANCISCO I-ORG\n8 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPORTUGUESE B-MISC\nFIRST O\nDIVISION O\nRESULT O\n. O\n\nLISBON B-LOC\n1996-08-24 O\n\nResult O\nof O\na O\nPortuguese B-MISC\nfirst O\n\ndivision O\nsoccer O\nmatch O\non O\nSaturday O\n: O\n\nBelenenses B-ORG\n2 O\nBoavista B-ORG\n4 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDISAPPOINTING O\nAJAX B-ORG\nSLUMP O\n2-0 O\nAT O\nHEERENVEEN B-LOC\n. O\n\nAMSTERDAM B-LOC\n1996-08-24 O\n\nDutch B-MISC\nchampions O\nAjax B-ORG\nAmsterdam I-ORG\nfaltered O\nin O\ntheir O\nsecond O\nleague O\nmatch O\nof O\nthe O\nseason O\non O\nSaturday O\nlosing O\n2-0 O\naway O\nat O\nHeerenveen B-ORG\n. O\n\nAjax B-ORG\n, O\nwho O\nhad O\na O\ndismal O\nseries O\nof O\npre-season O\nresults O\nbefore O\nbeating O\nNAC B-ORG\nof O\nBreda B-LOC\nin O\ntheir O\nopening O\ngame O\n, O\nhad O\nthe O\nbest O\nof O\nan O\nentertaining O\nfirst O\nhalf O\nbut O\nfailed O\nto O\nbreak O\nthe O\ndeadlock O\n. O\n\nEight O\nminutes O\nafter O\nthe O\ninterval O\n, O\nHeerenveen B-ORG\n's O\nRomeo B-PER\nWouden I-PER\nbroke O\nthrough O\nthe O\nAmsterdam B-LOC\ndefence O\n, O\nleft O\ndefender O\nJohn B-PER\nVeldman I-PER\nstanding O\nand O\ncurled O\nthe O\nball O\nbeyond O\ngoalkeeper O\nEdwin B-PER\nvan I-PER\nder I-PER\nSar I-PER\ninto O\nthe O\nAjax B-ORG\nnet O\n. O\n\nAjax B-ORG\n, O\nwithout O\ninjured O\ndefenders O\nMarcio B-PER\nSantos I-PER\nand O\nWinston B-PER\nBogarde I-PER\nand O\nstrikers O\nJari B-PER\nLitmanen I-PER\nand O\nMarc B-PER\nOvermars I-PER\n, O\nthen O\nstepped O\nup O\nthe O\npace O\nand O\nlooked O\ncertain O\nto O\nequalise O\n. O\n\nBut O\nthey O\nleft O\ngaps O\nat O\nthe O\nback O\nand O\non O\n73 O\nminutes O\nDanish B-MISC\nstriker O\nJon B-PER\nDahl I-PER\nTomasson I-PER\nrushed O\nout O\nof O\nhis O\nown O\nhalf O\n, O\nbeat O\nthe O\nAjax B-ORG\ndefence O\nand O\nlobbed O\nvan B-PER\nder I-PER\nSar I-PER\n. O\n\nThe O\ndefeat O\nmeans O\nAjax B-ORG\n's O\nmain O\ntitle O\ncontenders O\nPSV B-ORG\nEindhoven I-ORG\n, O\nwho O\nbeat O\nthe O\nchampions O\n3-0 O\nin O\nthe O\ntraditional O\nleague O\ncurtain-raiser O\n, O\ncan O\ngo O\nthree O\npoints O\nclear O\nof O\ntheir O\nrivals O\nif O\nthey O\nbeat O\nGroningen B-ORG\non O\nSunday O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBELGIAN B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n. O\n\nBRUSSELS B-LOC\n1996-08-24 O\n\nResults O\nof O\nBelgian B-MISC\nfirst O\n\ndivision O\nmatches O\non O\nSaturday O\n: O\n\nStandard B-ORG\nLiege I-ORG\n3 O\nMolenbeek B-ORG\n0 O\n\nAnderlecht B-ORG\n2 O\nLokeren B-ORG\n2 O\n\nCercle B-ORG\nBrugge I-ORG\n2 O\nMouscron B-ORG\n2 O\n\nAntwerp B-ORG\n1 O\nLommel B-ORG\n4 O\n\nGhent B-ORG\n3 O\nAalst B-ORG\n2 O\n\nLierse B-ORG\n4 O\nCharleroi B-ORG\n0 O\n\nSint B-ORG\nTruiden I-ORG\n3 O\nEkeren B-ORG\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nLEADING O\nFRENCH B-MISC\nLEAGUE O\nSCORERS O\n. O\n\nPARIS B-LOC\n1996-08-24 O\n\nLeading O\ngoalscorers O\nin O\nthe O\nFrench B-MISC\n\nfirst O\ndivision O\nafter O\nSaturday O\n's O\nmatches O\n: O\n\n3 O\n- O\nAnto B-PER\nDrobnjak I-PER\n( O\nBastia B-ORG\n) O\n, O\nXavier B-PER\nGravelaine I-PER\n( O\nMarseille B-ORG\n) O\n. O\n\n2 O\n- O\nMiladin B-PER\nBecanovic I-PER\n( O\nLille B-ORG\n) O\n, O\nEnzo B-PER\nScifo I-PER\n( O\nMonaco B-ORG\n) O\n, O\n\nVladimir B-PER\nSmicer I-PER\n( O\nLens B-ORG\n) O\n, O\nChristopher B-PER\nWreh I-PER\n( O\nGuingamp B-ORG\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nSUMMARIES O\n. O\n\nPARIS B-LOC\n1996-08-24 O\n\nSummaries O\nof O\nFrench B-MISC\nfirst O\ndivision O\n\nmatches O\non O\nSaturday O\n: O\n\nNantes B-ORG\n0 O\nLens B-ORG\n1 O\n( O\nSmicer B-PER\n52nd O\n) O\n. O\n\nHalftime O\n0-0 O\n. O\n\nAttendance O\n16,000 O\n. O\n\nNice B-ORG\n1 O\n( O\nDebbah B-PER\n39th O\n) O\nBastia B-ORG\n1 O\n( O\nDrobnjak B-PER\n82nd O\n) O\n. O\n\n1-0 O\n. O\n\n6,000 O\n. O\n\nLille B-ORG\n3 O\n( O\nBoutoille B-PER\n47th O\n, O\nBecanovic B-PER\n79th O\npen O\n, O\n82nd O\n) O\n) O\nRennes B-ORG\n1 O\n\n( O\nGuivarc'h B-PER\n60th O\npen O\n. O\n\n) O\n0-0 O\n. O\n\n6,000 O\n. O\n\nBordeaux B-ORG\n0 O\nAuxerre B-ORG\n0 O\n. O\n\n30,000 O\n. O\n\nMarseille B-ORG\n1 O\n( O\nGravelaine B-PER\n24th O\n) O\nMetz B-ORG\n2 O\n( O\nTraore B-PER\n65th O\n, O\nBombarda B-PER\n\n69th O\n) O\n. O\n\n1-0 O\n. O\n\n20,000 O\n. O\n\nStrasbourg B-ORG\n1 O\n( O\nZitelli B-PER\n80th O\n) O\nLe B-ORG\nHavre I-ORG\n0 O\n. O\n\n0-0 O\n. O\n\n15,000 O\n\nCaen B-ORG\n1 O\n( O\nBancarel B-PER\n70th O\n) O\nLyon B-ORG\n1 O\n( O\nCaveglia B-PER\n89th O\n) O\n. O\n\n0-0 O\n. O\n\n9,000 O\n. O\n\nGuingamp B-ORG\n2 O\n( O\nWreh B-PER\n15th O\n, O\n42nd O\n) O\nMonaco B-ORG\n1 O\n( O\nScifo B-PER\n35th O\n) O\n. O\n\n2-1 O\n. O\n\n7,000 O\n. O\n\nMontpellier B-ORG\n0 O\nCannes B-ORG\n1 O\n( O\nCharvet B-PER\n8th O\n) O\n. O\n\n0-1 O\n. O\n\n10,000 O\n. O\n\nPlayed O\non O\nFriday O\n: O\n\nNancy B-ORG\n0 O\nParis B-ORG\nSt I-ORG\nGermain I-ORG\n0 O\n. O\n\n15,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nSTANDINGS O\n. O\n\nPARIS B-LOC\n1996-08-24 O\n\nStandings O\nin O\nthe O\nFrench B-MISC\nsoccer O\n\nleague O\nafter O\nSaturday O\n's O\nmatches O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\n\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nLens B-ORG\n3 O\n3 O\n0 O\n0 O\n6 O\n1 O\n9 O\n\nBastia B-ORG\n3 O\n2 O\n1 O\n0 O\n4 O\n1 O\n7 O\n\nParis B-ORG\nSaint-Germain I-ORG\n3 O\n2 O\n1 O\n0 O\n3 O\n0 O\n7 O\n\nAuxerre B-ORG\n3 O\n2 O\n1 O\n0 O\n3 O\n0 O\n7 O\n\nCannes B-ORG\n3 O\n2 O\n1 O\n0 O\n4 O\n2 O\n7 O\n\nLille B-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n3 O\n6 O\n\nBordeaux B-ORG\n3 O\n1 O\n2 O\n0 O\n2 O\n1 O\n5 O\n\nMonaco B-ORG\n3 O\n1 O\n1 O\n1 O\n5 O\n3 O\n4 O\n\nMarseille B-ORG\n3 O\n1 O\n1 O\n1 O\n5 O\n4 O\n4 O\n\nMetz B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n3 O\n4 O\n\nLyon B-ORG\n3 O\n1 O\n1 O\n1 O\n4 O\n4 O\n4 O\n\nGuingamp B-ORG\n3 O\n1 O\n1 O\n1 O\n2 O\n2 O\n4 O\n\nRennes B-ORG\n3 O\n1 O\n0 O\n2 O\n4 O\n6 O\n3 O\n\nStrasbourg B-ORG\n3 O\n1 O\n0 O\n2 O\n1 O\n3 O\n3 O\n\nMontpellier B-ORG\n3 O\n0 O\n2 O\n1 O\n1 O\n2 O\n2 O\n\nNantes B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n5 O\n1 O\n\nNancy B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n5 O\n1 O\n\nNice B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n5 O\n1 O\n\nLe B-ORG\nHavre I-ORG\n3 O\n0 O\n1 O\n1 O\n1 O\n3 O\n1 O\n\nCaen B-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n5 O\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nRESULTS O\n. O\n\nPARIS B-LOC\n1996-08-24 O\n\nResults O\nof O\nFrench B-MISC\nfirst O\ndivision O\n\nmatches O\non O\nSaturday O\n: O\n\nNantes B-ORG\n0 O\nLens B-ORG\n1 O\n\nNice B-ORG\n1 O\nBastia B-ORG\n1 O\n\nLille B-ORG\n3 O\nRennes B-ORG\n1 O\n\nBordeaux B-ORG\n0 O\nAuxerre B-ORG\n0 O\n\nMarseille B-ORG\n1 O\nMetz B-ORG\n2 O\n\nStrasbourg B-ORG\n1 O\nLe B-ORG\nHavre I-ORG\n0 O\n\nCaen B-ORG\n1 O\nLyon B-ORG\n1 O\n\nGuingamp B-ORG\n2 O\nMonaco B-ORG\n1 O\n\nMontpellier B-ORG\n0 O\nCannes B-ORG\n1 O\n\nPlayed O\non O\nFriday O\n: O\n\nNancy B-ORG\n0 O\nParis B-ORG\nSt I-ORG\nGermain I-ORG\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nAMSTERDAM B-LOC\n1996-08-24 O\n\nResult O\nof O\nDutch B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatch O\nplayed O\non O\nSaturday O\n: O\n\nGraafschap B-ORG\nDoetinchem I-ORG\n3 O\nRKC B-ORG\nWaalwijk I-ORG\n2 O\n\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n0 O\nFortuna B-ORG\nSittard I-ORG\n1 O\n\nNAC B-ORG\nBreda I-ORG\n1 O\nSparta B-ORG\nRotterdam I-ORG\n0 O\n\nHeerenveen B-ORG\n2 O\nAjax B-ORG\nAmsterdam I-ORG\n0 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nGraafschap B-ORG\nDoetinchem I-ORG\n2 O\n1 O\n1 O\n0 O\n4 O\n3 O\n4 O\n\nFortuna B-ORG\nSittard I-ORG\n2 O\n1 O\n1 O\n0 O\n1 O\n0 O\n4 O\n\nPSV B-ORG\nEindhoven I-ORG\n1 O\n1 O\n0 O\n0 O\n4 O\n1 O\n3 O\n\nTwente B-ORG\nEnschede I-ORG\n1 O\n1 O\n0 O\n0 O\n3 O\n1 O\n3 O\n\nVitesse B-ORG\nArnhem I-ORG\n1 O\n1 O\n0 O\n0 O\n2 O\n0 O\n3 O\n\nHeerenveen B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n3 O\n3 O\n\nNAC B-ORG\nBreda I-ORG\n2 O\n1 O\n0 O\n1 O\n1 O\n1 O\n3 O\n\nAjax B-ORG\nAmsterdam I-ORG\n2 O\n1 O\n0 O\n1 O\n1 O\n2 O\n3 O\n\nUtrecht B-ORG\n1 O\n0 O\n1 O\n0 O\n2 O\n2 O\n1 O\n\nFeyenoord B-ORG\nRotterdam I-ORG\n1 O\n0 O\n1 O\n0 O\n1 O\n1 O\n1 O\n\nRoda B-ORG\nJC I-ORG\nKerkrade I-ORG\n1 O\n0 O\n1 O\n0 O\n1 O\n1 O\n1 O\n\nVolendam B-ORG\n1 O\n0 O\n1 O\n0 O\n1 O\n1 O\n1 O\n\nGroningen B-ORG\n1 O\n0 O\n1 O\n0 O\n0 O\n0 O\n1 O\n\nRKC B-ORG\nWaalwijk I-ORG\n2 O\n0 O\n1 O\n1 O\n4 O\n5 O\n1 O\n\nSparta B-ORG\nRotterdam I-ORG\n2 O\n0 O\n1 O\n1 O\n0 O\n1 O\n1 O\n\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n2 O\n0 O\n1 O\n1 O\n0 O\n1 O\n1 O\n\nAZ B-ORG\nAlkmaar I-ORG\n1 O\n0 O\n0 O\n1 O\n0 O\n2 O\n0 O\n\nNEC B-ORG\nNijmegen I-ORG\n1 O\n0 O\n0 O\n1 O\n1 O\n4 O\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSUMMARIES O\nOF O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nMATCHES O\n. O\n\nBONN B-LOC\n1996-08-24 O\n\nSummaries O\nof O\nGerman B-MISC\nfirst O\ndivision O\n\nmatches O\nplayed O\non O\nSaturday O\n: O\n\nBochum B-ORG\n1 O\n( O\nJack B-PER\n66th O\nminute O\n) O\nArminia B-ORG\nBielefeld I-ORG\n1 O\n( O\nMolata B-PER\n59th O\n) O\n. O\n\nHalftime O\n0-0 O\n. O\n\nAttendance O\n25,000 O\n\nBorussia B-ORG\nMoenchengladbach I-ORG\n1 O\n( O\nAndersson B-PER\n22nd O\n) O\nKarlsruhe B-ORG\n3 O\n\n( O\nHaessler B-PER\n33rd O\n, O\nDundee B-PER\n45th O\n, O\nKeller B-PER\n90th O\n) O\n. O\n\n1-2 O\n. O\n\n20,000 O\n\nStuttgart B-ORG\n2 O\n( O\nBalakow B-PER\n50th O\n, O\nBobic B-PER\n61st O\n) O\nWerder B-ORG\nBremen I-ORG\n1 O\n( O\nVotava B-PER\n\n68th O\n) O\n. O\n\n0-0 O\n. O\n\n32,000 O\n\n1860 B-ORG\nMunich I-ORG\n1 O\n( O\nSchwabl B-PER\n38th O\n) O\nBorussia B-ORG\nDortmund I-ORG\n3 O\n( O\nZorc B-PER\n\n59th-pen O\n, O\nMoeller B-PER\n73rd O\n, O\nHeinrich B-PER\n90th O\n) O\n. O\n\n1-0 O\n. O\n\n50,000 O\n\nBayer B-ORG\nLeverkusen I-ORG\n0 O\nFortuna B-ORG\nDuesseldorf I-ORG\n1 O\n( O\nSeeliger B-PER\n47th O\n) O\n. O\n\n0-0 O\n. O\n\n18,000 O\n\nFreiburg B-ORG\n1 O\n( O\nZeyer B-PER\n52nd O\n) O\nCologne B-ORG\n3 O\n( O\nGaissmayer B-PER\n9th O\n, O\nPolster B-PER\n\n86th O\n, O\n90th O\n) O\n. O\n\n0-1 O\n. O\n\n22,500 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nRESULTS O\nOF O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nMATCHES O\n. O\n\nBONN B-LOC\n1996-08-24 O\n\nResults O\nof O\nGerman B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatches O\nplayed O\non O\nSaturday O\n: O\n\nBochum B-ORG\n1 O\nArminia B-ORG\nBielefeld I-ORG\n1 O\n\nBorussia B-ORG\nMoenchengladbach I-ORG\n1 O\nKarlsruhe B-ORG\n3 O\n\nStuttgart B-ORG\n2 O\nWerder B-ORG\nBremen I-ORG\n1 O\n\n1860 B-ORG\nMunich I-ORG\n1 O\nBorussia B-ORG\nDortmund I-ORG\n3 O\n\nBayer B-ORG\nLeverkusen I-ORG\n0 O\nFortuna B-ORG\nDuesseldorf I-ORG\n1 O\n\nFreiburg B-ORG\n1 O\nCologne B-ORG\n3 O\n\nPlayed O\non O\nSaturday O\n: O\n\nSt B-ORG\nPauli I-ORG\n4 O\nSchalke B-ORG\n4 O\n\nHansa B-ORG\nRostock I-ORG\n0 O\nHamburg B-ORG\n1 O\n\nBundesliga B-MISC\nstandings O\nafter O\nSaturday O\n's O\ngames O\n( O\ntabulate O\nunder O\n\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nCologne B-ORG\n3 O\n3 O\n0 O\n0 O\n7 O\n1 O\n9 O\n\nVfB B-ORG\nStuttgart I-ORG\n2 O\n2 O\n0 O\n0 O\n6 O\n1 O\n6 O\n\nBorussia B-ORG\nDortmund I-ORG\n3 O\n2 O\n0 O\n1 O\n9 O\n5 O\n6 O\n\nHamburg B-ORG\n3 O\n2 O\n0 O\n1 O\n7 O\n3 O\n6 O\n\nBayer B-ORG\nLeverkusen I-ORG\n3 O\n2 O\n0 O\n1 O\n7 O\n4 O\n6 O\n\nVfL B-ORG\nBochum I-ORG\n3 O\n1 O\n2 O\n0 O\n3 O\n2 O\n5 O\n\nKarlsruhe B-ORG\n2 O\n1 O\n1 O\n0 O\n5 O\n3 O\n4 O\n\nBayern B-ORG\nMunich I-ORG\n2 O\n1 O\n1 O\n0 O\n3 O\n2 O\n4 O\n\nSt B-ORG\nPauli I-ORG\n3 O\n1 O\n1 O\n1 O\n7 O\n7 O\n4 O\n\n1860 B-ORG\nMunich I-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n5 O\n3 O\n\nFreiburg B-ORG\n3 O\n1 O\n0 O\n2 O\n5 O\n10 O\n3 O\n\nFortuna B-ORG\nDuesseldorf I-ORG\n3 O\n1 O\n0 O\n2 O\n1 O\n7 O\n3 O\n\nHansa B-ORG\nRostock I-ORG\n3 O\n0 O\n2 O\n1 O\n3 O\n4 O\n2 O\n\nArminia B-ORG\nBielefeld I-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n3 O\n2 O\n\nBorussia B-ORG\nMoenchengladbach I-ORG\n3 O\n0 O\n2 O\n1 O\n1 O\n3 O\n2 O\n\nSchalke B-ORG\n3 O\n0 O\n2 O\n1 O\n4 O\n8 O\n2 O\n\nWerder B-ORG\nBremen I-ORG\n3 O\n0 O\n1 O\n2 O\n4 O\n6 O\n1 O\n\nMSV B-ORG\nDuisburg I-ORG\n2 O\n0 O\n0 O\n2 O\n1 O\n4 O\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nAUSTRIA B-LOC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nVIENNA B-LOC\n1996-08-24 O\n\nResults O\nof O\nAustria B-LOC\nfirst O\ndivision O\n\nsoccer O\nmatches O\nplayed O\non O\nSaturday O\n: O\n\nRapid B-ORG\nVienna I-ORG\n0 O\nFC B-ORG\nLinz I-ORG\n0 O\n\nGAK B-ORG\n2 O\nAustria B-ORG\nVienna I-ORG\n2 O\n\nAdmira B-ORG\n/ I-ORG\nWacker I-ORG\n0 O\nSturm B-ORG\nGraz I-ORG\n3 O\n\nLinzer B-ORG\nASK I-ORG\n1 O\nFC B-ORG\nTirol I-ORG\nInnsbruck I-ORG\n3 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nFC B-ORG\nTirol I-ORG\nInnsbruck I-ORG\n6 O\n4 O\n2 O\n0 O\n13 O\n5 O\n14 O\n\nAustria B-ORG\nVienna I-ORG\n6 O\n4 O\n2 O\n0 O\n9 O\n5 O\n14 O\n\nSV B-ORG\nSalzburg I-ORG\n5 O\n3 O\n2 O\n0 O\n4 O\n1 O\n11 O\n\nSturm B-ORG\nGraz I-ORG\n6 O\n2 O\n3 O\n1 O\n8 O\n5 O\n9 O\n\nGAK B-ORG\n6 O\n1 O\n3 O\n2 O\n8 O\n10 O\n6 O\n\nRapid B-ORG\nWien I-ORG\n5 O\n0 O\n5 O\n0 O\n3 O\n3 O\n5 O\n\nSV B-ORG\nRied I-ORG\n5 O\n1 O\n1 O\n3 O\n6 O\n5 O\n4 O\n\nLinzer B-ORG\nASK I-ORG\n5 O\n0 O\n3 O\n2 O\n4 O\n8 O\n3 O\n\nAdmira B-ORG\n/ I-ORG\nWacker I-ORG\n6 O\n0 O\n3 O\n3 O\n5 O\n10 O\n3 O\n\nFC B-ORG\nLinz I-ORG\n6 O\n0 O\n2 O\n4 O\n1 O\n9 O\n2 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nRAIN O\nBRINGS O\nPREMATURE O\nEND O\nTO O\nSRI B-LOC\nLANKA I-LOC\nMATCH O\n. O\n\nCOLOMBO B-LOC\n1996-08-24 O\n\nThe O\none-day O\nmatch O\nbetween O\nSri B-LOC\nLanka I-LOC\nand O\na O\nWorld B-ORG\nXI I-ORG\nwas O\nabandoned O\non O\nSaturday O\nbecause O\nof O\nrain O\n. O\n\nScores O\n: O\nWorld B-ORG\nXI I-ORG\n102-0 O\n( O\nM. B-PER\nWaugh I-PER\n39 O\nnot O\nout O\n, O\nS. B-PER\nTendulkar I-PER\n56 O\nnot O\nout O\n) O\noff O\n21.4 O\novers O\nv O\nSri B-LOC\nLanka I-LOC\n. O\n\n-DOCSTART- O\n\nBritish B-MISC\nhostage O\nin O\nChechnya B-LOC\ndescribes O\nordeal O\n. O\n\nLONDON B-LOC\n1996-08-24 O\n\nA O\nBritish B-MISC\naid O\nworker O\n, O\nheld O\nhostage O\nin O\nChechnya B-LOC\nfor O\nnearly O\nfour O\nweeks O\n, O\nsaid O\non O\nSaturday O\na O\ncocked O\nKalashnikov B-MISC\nhad O\nbeen O\nthrust O\ninto O\nhis O\nmouth O\nat O\none O\npoint O\nduring O\nhis O\nordeal O\n. O\n\nMichael B-PER\nPenrose I-PER\n, O\na O\n23-year-old O\nworker O\nwith O\nthe O\ngroup O\nAction B-ORG\nAgainst I-ORG\nHunger I-ORG\n, O\ndescribed O\nhis O\nordeal O\nto O\na O\nnews O\nconference O\nwhen O\nhe O\narrived O\nback O\nin O\nBritain B-LOC\nfrom O\nMoscow B-LOC\n. O\n\n\" O\nThe O\nworst O\nperiod O\nof O\nphysical O\nmanhandling O\nwas O\nduring O\nthat O\ntime O\nwhen O\nwe O\nwere O\nbeaten O\nwith O\nKalashnikovs B-MISC\nand O\nat O\none O\npoint O\nI O\nhad O\na O\nKalashnikov B-MISC\nheld O\nto O\nthe O\nback O\nof O\nmy O\nthroat O\n-- O\ncocked O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nFor O\nthe O\nfirst O\nperiod O\nwe O\nwere O\nheld O\nin O\na O\nsmall O\nroom O\nwith O\nno O\nbed O\nor O\nanything O\n. O\n\nWe O\nhad O\nvery O\nlittle O\nfood O\nand O\nsometimes O\nwent O\ntwo O\nor O\nthree O\ndays O\nwithout O\neating O\n. O\n\" O\n\nGunmen O\nseized O\nPenrose B-PER\n, O\nwho O\ncomes O\nfrom O\nSwerford B-LOC\nin O\nsouthern O\nEngland B-LOC\n, O\nFrenchman B-MISC\nFrederic B-PER\nMalardeau I-PER\nand O\nsix O\nother O\nhostages O\nfrom O\ntheir O\ncar O\nin O\nGrozny B-LOC\n, O\nthe O\ncapital O\nof O\nChechnya B-LOC\n, O\non O\nJuly O\n27 O\n. O\n\nThe O\nassailants O\nhad O\ndemanded O\na O\nransom O\nof O\n300,000 O\npounds O\n( O\n$ O\n465,000 O\n) O\nbut O\nno O\nmoney O\nwas O\npaid O\nby O\nthe O\ncharity O\nwhen O\nthey O\nwere O\nreleased O\non O\nWednesday O\n. O\n\nThe O\nhostages O\nwere O\nheld O\nin O\na O\nhouse O\nin O\nor O\nnear O\nGrozny B-LOC\nwhich O\nwas O\nbombarded O\nregularly O\n. O\n\n\" O\nDuring O\nthe O\nlast O\n15 O\ndays O\nof O\nbeing O\nheld O\n, O\nthe O\nfighting O\nin O\nGrozny B-LOC\nwas O\nvery O\nclose O\n. O\n\nAt O\nfirst O\nit O\nwas O\nstreet O\nfighting O\noutside O\nthe O\nhouse O\nand O\nthen O\nwe O\ncame O\nunder O\nvery O\nheavy O\nshelling O\nand O\nbombardment O\nfrom O\nconventional O\nweapons O\nlike O\ntanks O\n, O\nartillery O\nand O\ngrenade O\nlaunchers O\n, O\n\" O\nhe O\nsaid O\n. O\n\nPenrose B-PER\nhad O\nbeen O\nworking O\nfor O\nthe O\ncharity O\nwhich O\nprovides O\nfood O\nto O\ncivilians O\nfor O\nonly O\na O\nfew O\nweeks O\nbefore O\nhe O\nwas O\ncaptured O\n. O\n\nWhen O\nasked O\nif O\nhe O\nwould O\nreturn O\nto O\nthe O\nmountainous O\nregion O\nwhere O\nrebels O\nhave O\nbeen O\nfighting O\nRussian B-MISC\ntroops O\nfor O\nfull O\nindependence O\n, O\nPenrose B-PER\nsaid O\n: O\n\" O\nNot O\nfor O\nthe O\ntime O\nbeing O\n. O\n\nI O\ndo O\nn't O\nthink O\nit O\n's O\nsafe O\nfor O\nme O\n. O\n\nBut O\nmaybe O\nin O\nthe O\nfuture O\n, O\ndepending O\non O\nthe O\ncircumstances O\n. O\n\" O\n\n-DOCSTART- O\n\nPrincess O\nDiana B-PER\nsend O\nmessage O\nto O\nMother B-PER\nTeresa I-PER\n. O\n\nLONDON B-LOC\n1996-08-24 O\n\nBritain B-LOC\n's O\nPrincess O\nDiana B-PER\nhas O\nsent O\na O\nmessage O\nto O\nseriously O\nill O\nMother B-PER\nTeresa I-PER\n, O\nthe O\nnun O\nto O\nwhom O\nshe O\nhas O\nturned O\nseveral O\ntimes O\nfor O\nspiritual O\nguidance O\n. O\n\nDiana B-PER\n's O\noffice O\nsaid O\non O\nSaturday O\nthe O\nprincess O\nhad O\nsent O\na O\nmessage O\nto O\nthe O\nNobel B-MISC\nPeace I-MISC\nPrize-winning I-MISC\nmissionary O\nas O\nnews O\nbroke O\nthis O\nweek O\nof O\nher O\nbattle O\nagainst O\nheart O\nproblems O\nand O\nmalaria O\n. O\n\nA O\nspokeswoman O\ndeclined O\nto O\nrelease O\ndetails O\nof O\nthe O\nmessage O\n. O\n\nDiana B-PER\nfirst O\nmet O\nthe O\nAlbanian-born B-MISC\nmissionary O\nin O\nRome B-LOC\nin O\n1992 O\n. O\n\nShe O\nsaid O\nafterwards O\nthat O\nthe O\nmeeting O\nhad O\nfulfilled O\nher O\n\" O\ndearest O\nwish O\n\" O\nand O\nthe O\ntwo O\nwomen O\nhave O\nmet O\nseveral O\ntimes O\nsince O\n. O\n\nThe O\nprincess O\n, O\nwho O\nhas O\ncarved O\nout O\na O\nmajor O\nrole O\nfor O\nherself O\nas O\na O\nhelper O\nof O\nthe O\nsick O\nand O\nneedy O\n, O\nis O\nsaid O\nto O\nhave O\nturned O\nto O\nMother B-PER\nTeresa I-PER\nfor O\nguidance O\nas O\nher O\nmarriage O\ncrumbled O\nto O\nheir O\nto O\nthe O\nBritish B-MISC\nthrone O\nPrince B-PER\nCharles I-PER\n. O\n\nThe O\n85-year-old O\nnun O\nsaid O\nin O\nthe O\npast O\nthat O\nshe O\nwas O\npraying O\nfor O\nthe O\ncouple O\n, O\nwhose O\ndivorce O\nis O\nexpected O\nto O\nbecome O\nfinal O\nnext O\nweek O\n. O\n\nDoctors O\ncaring O\nfor O\nMother B-PER\nTeresa I-PER\nin O\na O\nCalcutta B-LOC\nhospital O\nsaid O\non O\nSaturday O\nthat O\nher O\nfever O\nhad O\nfallen O\nand O\nher O\nmalaria O\nwas O\nunder O\ncontrol O\nbut O\nshe O\nremained O\non O\na O\nrespirator O\nin O\nintensive O\ncare O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\n339-4 O\nV O\nENGLAND B-LOC\n- O\nclose O\n. O\n\nSaeed B-PER\nAnwar I-PER\nc O\nCroft B-PER\nb O\nCork B-PER\n176 O\n\nAamir B-PER\nSohail I-PER\nc O\nCork B-PER\nb O\nCroft B-PER\n46 O\n\nIjaz B-PER\nAhmed I-PER\nc O\nStewart B-PER\nb O\nMullally B-PER\n61 O\n\nInzamam-ul-Haq B-PER\nc O\nHussain B-PER\nb O\nMullally B-PER\n35 O\n\nSalim B-PER\nMalik I-PER\nnot O\nout O\n2 O\n\nAsif B-PER\nMujtaba I-PER\nnot O\nout O\n1 O\n\nExtras O\n18 O\n\nFall O\nof O\nwicket O\n- O\n1-106 O\n2-239 O\n3-334 O\n4-334 O\n\nTo O\nbat O\n- O\nWasim B-PER\nAkram I-PER\n, O\nMoin B-PER\nKhan I-PER\n, O\nMushtaq B-PER\nAhmed I-PER\n, O\nWaqar B-PER\nYounis I-PER\n, O\nMohammad B-PER\nAkam I-PER\n\nEngland B-LOC\n326 O\nall O\nout O\n\n-DOCSTART- O\n\nSoccer O\n- O\nNijmeh B-ORG\nbeat O\nNasr B-ORG\n1-0 O\n. O\n\nTRIPOLI B-LOC\n, O\nLebanon B-LOC\n1996-08-24 O\n\nNijmeh B-ORG\nof O\nLebanon B-LOC\nbeat O\nNasr B-ORG\nof O\nSaudi B-LOC\nArabia I-LOC\n1-0 O\n( O\nhalftime O\n1-0 O\n) O\nin O\ntheir O\nAsian B-MISC\nclub O\nchampionship O\nsecond O\nround O\nfirst O\nleg O\ntie O\non O\nSaturday O\n. O\n\nScorer O\n: O\nIssa B-PER\nAlloush I-PER\n( O\n45th O\nminute O\n) O\n. O\n\nAttendance O\n: O\n10,000 O\n. O\n\n-DOCSTART- O\n\nAdventurers O\nstart O\nCanadian B-MISC\nwilderness O\nrace O\n. O\n\nPEMBERTON B-LOC\n, O\nBritish B-LOC\nColumbia I-LOC\n1996-08-24 O\n\nAbout O\n350 O\nadventurers O\nfrom O\nnine O\ncountries O\nset O\nout O\non O\nSaturday O\nto O\nclimb O\n, O\nraft O\n, O\nbike O\nand O\nrun O\nin O\na O\n323-mile O\n( O\n517-km O\n) O\nendurance O\nrace O\nthrough O\nthe O\nCanadian B-MISC\nwilderness O\n. O\n\nThe O\nevent O\n, O\ncalled O\nthe O\nEco-Challenge B-MISC\n, O\nis O\npart O\nof O\na O\ngrowing O\nsport O\nknown O\nas O\nadventure O\nracing O\nin O\nwhich O\ncompetitors O\ntest O\ntheir O\nlimits O\nfor O\ndays O\nover O\na O\nperilous O\nwilderness O\ncourse O\n. O\n\n\" O\nI O\n'm O\nlooking O\nforward O\nto O\nthis O\nrace O\n. O\n\nI O\nthink O\nit O\nwill O\nbe O\nmore O\nphysically O\nchallenging O\nand O\nwe O\n'll O\nhave O\nto O\ngo O\nup O\nagainst O\nmore O\ndiverse O\nsituations O\ndue O\nto O\nthe O\nterrain O\n, O\n\" O\nsaid O\nDr. O\nMichael B-PER\nStroud I-PER\n, O\na O\nveteran O\nEco-Challenge B-MISC\nparticipant O\n. O\n\nThe O\nEco-Challenge B-MISC\nhas O\nbeen O\nstaged O\ntwice O\nbefore O\n-- O\nin O\nUtah B-LOC\nand O\nMaine B-LOC\nlast O\nyear O\n-- O\nand O\nis O\nmodelled O\non O\nsimilar O\nraces O\noverseas O\n. O\n\nThe O\n70 O\nteams O\nin O\nthis O\nyear O\n's O\nrace O\nwill O\nwill O\ntrek O\nglaciers O\n, O\nclimb O\nmountains O\n, O\nwhitewater O\nraft O\n, O\nhorseback O\nride O\n, O\ncanoe O\nand O\nmountain O\nbike O\nalong O\nthe O\ngrueling O\ncourse O\n. O\n\nThis O\nyear O\n's O\nrace O\n, O\nthe O\nroute O\nof O\nwhich O\nwas O\nkeep O\na O\nsecret O\nuntil O\nFriday O\nevening O\n, O\nis O\nbeing O\nheld O\nnear O\nPemberton B-LOC\n, O\nBritish B-LOC\nColumbia I-LOC\n, O\nabout O\n100 O\nmiles O\n( O\n160 O\nkm O\n) O\nnortheast O\nof O\nVancouver B-LOC\n. O\n\nThe O\narea O\nis O\nfilled O\nwith O\ntreacherous O\nmountain O\npeaks O\n, O\nice O\nfields O\nand O\nfrigid O\nwaters O\n. O\n\nOrganisers O\nexpect O\nabout O\ntwo-thirds O\nof O\nthe O\nparticipants O\nto O\ndrop O\nout O\nor O\nbe O\ndisqualified O\nbefore O\nthe O\nfinish O\n. O\n\nThe O\nhardy O\nones O\nare O\nexpected O\nto O\ncomplete O\nthe O\ncourse O\nin O\nabout O\nsix O\ndays O\n, O\nwith O\nfirst-place O\nfinishers O\nreceiving O\n$ O\n10,000 O\nin O\nprize O\nmoney O\n. O\n\nIn O\nthe O\nEco-Challenge B-MISC\n, O\ncompetitors O\nrace O\nin O\nteams O\nof O\nfive O\nwhich O\nmust O\ninclude O\nboth O\nmen O\nand O\nwomen O\n. O\n\nTeam O\nmembers O\nmust O\nremain O\nwithin O\n100 O\nyards O\n( O\nmetres O\n) O\nof O\neach O\nother O\nat O\nall O\ntimes O\nand O\nfinish O\ntogether O\n. O\n\nWith O\nracers O\ncarrying O\nabout O\n40 O\npounds O\n( O\n18 O\nkg O\n) O\nof O\ngear O\non O\ntheir O\nbacks O\n, O\nbroken O\nbones O\n, O\nsunstroke O\n, O\ndehydration O\nand O\nexhaustion O\nare O\ncommon O\n. O\n\n-DOCSTART- O\n\nCholera O\nkills O\n21 O\nin O\nsouthern O\nNigeria B-LOC\n. O\n\nLAGOS B-LOC\n1996-05-28 O\n\nAn O\noutbreak O\nof O\ncholera O\nhas O\nkilled O\n21 O\npeople O\nin O\na O\nweek O\nat O\nUbimini B-LOC\nin O\noil-rich O\nsouthern O\nNigeria B-LOC\n, O\nthe O\nNews B-ORG\nAgency I-ORG\nof I-ORG\nNigeria I-ORG\nreported O\non O\nSaturday O\n. O\n\nThe O\nchairman O\nof O\nthe O\nlocal O\ncouncil O\n, O\nDamian B-PER\nEjiohuo I-PER\n, O\nsaid O\ndrugs O\nhad O\nbeen O\nrushed O\nto O\nthe O\narea O\nto O\nquell O\nthe O\ndisease O\nand O\nthe O\ncommunity O\nneeded O\na O\nsafer O\nsource O\nof O\ndrinking O\nwater O\nto O\nprevent O\nfuture O\noutbreaks O\n. O\n\nEpidemics O\nare O\ncommon O\nin O\nrural O\nareas O\nof O\nNigeria B-LOC\nwhere O\npiped O\nwater O\nis O\nnot O\nusually O\navailable O\n. O\n\n-DOCSTART- O\n\nMalawi B-LOC\n's O\nex-president O\nBanda B-PER\nsays O\nhe O\n's O\nfeeling O\nwell O\n. O\n\nBLANTYRE B-LOC\n1996-08-24 O\n\nMalawi B-LOC\n's O\nfrail O\nformer O\npresident O\n, O\nKamuzu B-PER\nBanda I-PER\n, O\nsaid O\non O\nSaturday O\nin O\na O\nrare O\npublic O\ninterview O\nthat O\nhe O\nwas O\nfeeling O\nwell O\ndespite O\nhis O\nadvanced O\nyears O\n. O\n\n\" O\nI O\nfeel O\nall O\nright O\nand O\nI O\neat O\neverything O\nthat O\nis O\nput O\non O\nthe O\ntable O\n. O\n\nAnd O\nthat O\nmeans O\nI O\nam O\nall O\nright O\n, O\n\" O\nhe O\ntold O\nreporters O\ninvited O\nto O\nhis O\nhome O\n. O\n\nBanda B-PER\n, O\na O\nvegetarian O\nteetotaller O\nbelieved O\nto O\nbe O\n97 O\n, O\nwalked O\nunaided O\nbut O\nsupporting O\nhimself O\non O\na O\nwalking O\nstick O\n. O\n\nHe O\nclutched O\na O\nfly O\nwhisk O\nwhich O\nfor O\na O\nlong O\ntime O\nsymbolised O\nhis O\nobsession O\nwith O\npower O\n. O\n\nHis O\nhealth O\nwas O\nthe O\nsubject O\nof O\nmuch O\nrecent O\nspeculation O\n. O\n\nMalawi B-LOC\n's O\nundisputed O\nruler O\nfor O\nthree O\ndecades O\n, O\nhe O\nlost O\npower O\nin O\nthe O\nfirst O\nall-party O\nelections O\nin O\n1994 O\n. O\n\nHe O\nspent O\na O\nyear O\nunder O\nhouse O\narrest O\nand O\nwas O\ntried O\nbut O\nacquitted O\nlast O\nyear O\non O\ncharges O\nof O\nordering O\nthe O\nmurder O\nof O\nfour O\nopponents O\nin O\n1983 O\n. O\n\n-DOCSTART- O\n\nZimbabwe B-LOC\nfires O\nstriking O\ncivil O\nservants O\n. O\n\nEmelia B-PER\nSithole I-PER\n\nHARARE B-LOC\n1996-08-24 O\n\nThe O\nZimbabwean B-MISC\ngovernment O\nfired O\nthousands O\nof O\nworkers O\non O\nSaturday O\nfor O\ndefying O\nan O\norder O\nto O\nend O\na O\nstrike O\nwhich O\nhas O\ncrippled O\nessential O\nservices O\nand O\ndisrupted O\ninternational O\nand O\ndomestic O\nflights O\n. O\n\nThe O\nPublic B-ORG\nService I-ORG\nCommission I-ORG\n( O\nPSC B-ORG\n) O\nsaid O\nin O\na O\nstatement O\nthat O\nthe O\nworkers O\n-- O\nincluding O\nnurses O\n, O\njunior O\ndoctors O\n, O\nmortuary O\nattendants O\n, O\ncustoms O\nofficers O\nand O\nfirefighters O\n-- O\nwould O\nbe O\nbarred O\nfrom O\nentering O\ntheir O\nworkplaces O\non O\nMonday O\n. O\n\n\" O\nAll O\ncivil O\nservants O\nwho O\ndid O\nnot O\nreturn O\nto O\nwork O\nat O\ntheir O\nnormal O\nworking O\nhours O\n, O\nand O\nremained O\nworking O\nfor O\nthe O\nfull O\nworking O\nday O\non O\n23 O\nAugust O\n1996 O\n, O\nhave O\nbeen O\nsummarily O\ndismissed O\n... O\n\nwith O\nimmediate O\neffect O\n, O\n\" O\nit O\nsaid O\nin O\na O\nstatement O\n. O\n\nUnion O\nofficials O\nfrom O\nthe O\nPublic B-ORG\nService I-ORG\nAssociation I-ORG\n( O\nPSA B-ORG\n) O\nwere O\nunavailable O\nfor O\ncomment O\n. O\n\nPublic B-ORG\nService I-ORG\n, I-ORG\nLabour I-ORG\nand I-ORG\nSocial I-ORG\nWelfare I-ORG\nMinister O\nFlorence B-LOC\nChitauro O\ntold O\nstate O\nradio O\nher O\nministry O\nhad O\nalready O\nbegun O\nrecruiting O\nother O\npeople O\nto O\nreplace O\nthe O\nstrikers O\n, O\nsub-contracting O\nsome O\nof O\nthe O\nwork O\nto O\nprivate O\nfirms O\n. O\n\nThe O\ngovernment O\nhad O\nbeen O\nthreatening O\nto O\nfire O\nthe O\nworkers O\nsince O\nthe O\nstrike O\nbegan O\non O\nTuesday O\n, O\nsaying O\nit O\nwas O\nillegal O\n. O\n\nBut O\nthe O\nstrikers O\nignored O\nthe O\nthreat O\nand O\nvowed O\nto O\nstay O\non O\nthe O\nstreets O\nuntil O\ntheir O\ndemands O\nfor O\nwage O\nrises O\nof O\n30 O\nto O\n60 O\npercent O\nwere O\nmet O\n. O\n\nThe O\nstoppage O\nhas O\nleft O\nessential O\nservices O\nstretched O\nwith O\nmany O\nhospitals O\nhandling O\nonly O\nemergency O\ncases O\nunder O\nsenior O\ndoctors O\nwith O\nthe O\nhelp O\nof O\narmy O\nmedical O\npersonnel O\nand O\nthe O\nRed B-ORG\nCross I-ORG\n. O\n\nIt O\nhas O\nalso O\ndisrupted O\nflights O\n. O\n\nSome O\ninternal O\nservices O\nwere O\ncancelled O\n, O\nleaving O\ntourists O\nat O\nthe O\nVictoria B-LOC\nFalls I-LOC\nresort O\nstranded O\n, O\nand O\nflights O\nabroad O\nwere O\ndelayed O\n. O\n\nThe O\nPSA B-ORG\nsaid O\n80 O\npercent O\nof O\nthe O\ncountry O\n's O\n180,000 O\ncivil O\nservants O\ntook O\npart O\nin O\nthe O\nstrike O\nwhich O\nis O\na O\nrare O\nchallenge O\nto O\nPresident O\nRobert B-PER\nMugabe I-PER\n, O\nwho O\nhas O\nbeen O\nin O\npower O\nsince O\nindependence O\nfrom O\nBritain B-LOC\nin O\n1980 O\n. O\n\nOpposition O\nparties O\n, O\ncivic O\norganisations O\nand O\nprivate-sector O\nunions O\nhave O\nexpressed O\nsupport O\nfor O\nthe O\naction O\nand O\ndenounced O\nthe O\ngovernment O\n's O\npay O\nrises O\nof O\nup O\nto O\neight O\npercent O\nfor O\nits O\nworkers O\n. O\n\nCivil O\nservants O\nearn O\non O\naverage O\nZ$ B-MISC\n1,000 O\n( O\n$ O\n100 O\n) O\na O\nmonth O\n. O\n\nThey O\nsay O\ntheir O\npay O\nhas O\nnot O\nkept O\nup O\nat O\nall O\nwith O\ninflation O\n, O\ncurrently O\nrunning O\nat O\n22 O\npercent O\n. O\n\n-DOCSTART- O\n\nRwanda B-LOC\nsays O\nZaire B-LOC\nexpels O\n28 O\nRwandan B-MISC\nrefugees O\n. O\n\nKIGALI B-LOC\n1996-08-24 O\n\nRwanda B-LOC\nsaid O\non O\nSaturday O\nthat O\nZaire B-LOC\nhad O\nexpelled O\n28 O\nRwandan B-MISC\nHutu B-MISC\nrefugees O\naccused O\nof O\nbeing O\n\" O\ntrouble-makers O\n\" O\nin O\ncamps O\nin O\neastern O\nZaire B-LOC\n. O\n\nCaptain O\nFirmin B-PER\nGatera I-PER\n, O\nspokesman O\nfor O\nthe O\nTutsi-dominated B-MISC\nRwandan B-MISC\narmy O\n, O\ntold O\nReuters B-ORG\nin O\nKigali B-LOC\nthat O\n17 O\nof O\nthe O\n28 O\nrefugees O\nhanded O\nover O\non O\nFriday O\nfrom O\nthe O\nZairean B-MISC\ntown O\nof O\nGoma B-LOC\nhad O\nbeen O\nsoldiers O\nin O\nthe O\nformer O\nHutu B-MISC\narmy O\nwhich O\nfled O\nto O\nZaire B-LOC\nin O\n1994 O\nafter O\nbeing O\ndefeated O\nby O\nTutsi B-MISC\nforces O\nin O\nRwanda B-LOC\n's O\ncivil O\nwar O\n. O\n\nZairean B-MISC\nPrime O\nMinister O\nKengo B-PER\nwa I-PER\nDondo I-PER\nsaid O\non O\nThursday O\nin O\na O\nvisit O\nto O\nRwanda B-LOC\nthat O\nhis O\ncountry O\nwould O\nexpell O\nall O\nthe O\nrefugees O\nback O\nto O\nRwanda B-LOC\nbut O\nhe O\ngave O\nno O\ntimeframe O\n. O\n\nZaire B-LOC\nis O\nhome O\nto O\n1.1 O\nmillion O\nRwandan B-MISC\nHutu B-MISC\nrefugees O\nwho O\nfled O\nthree O\nmonths O\nof O\ncivil O\nwar O\nin O\n1994 O\n. O\n\nMany O\nhad O\ntaken O\npart O\nin O\nthe O\ngenocide O\nthat O\nyear O\nof O\none O\nmillion O\npeople O\n, O\nmostly O\nTutsis B-MISC\n, O\nand O\nrefuse O\nto O\ngo O\nhome O\nfor O\nfear O\nof O\nreprisal O\nat O\nthe O\nhands O\nof O\nthe O\nnew O\nTutsi-dominated B-MISC\ngovernment O\nin O\nKigali B-LOC\n. O\n\nGatera B-PER\nsaid O\nthe O\nrefugees O\nwere O\nhanded O\nover O\nfollowing O\na O\ndeal O\nmade O\nat O\na O\nmeeting O\nbetween O\nthe O\ngovernor O\nof O\nZaire B-LOC\n's O\nnorth O\nKivu B-LOC\nregion O\nand O\nhis O\ncounterpart O\nin O\nthe O\nRwandan B-MISC\nborder O\ntown O\nof O\nGisenyi B-LOC\n. O\n\n\" O\nAfter O\na O\nmeeting O\nbetween O\nthe O\ngovernor O\nof O\nnorth O\nKivu B-LOC\nand O\nthe O\nprefect O\nof O\nGisenyi B-LOC\n, O\n28 O\nprisoners O\n( O\nrefugees O\n) O\nwere O\nhanded O\nover O\nto O\nRwandan B-MISC\nauthorities O\non O\nFriday O\n, O\n\" O\nGatera B-PER\nsaid O\n. O\n\" O\n\nOut O\nof O\nthese O\n17 O\nwere O\nformer O\nsoldiers O\n. O\n\nThese O\npeople O\nare O\nnow O\nin O\nGisenyi B-LOC\nprison O\n, O\n\" O\nGatera B-PER\nadded O\n. O\n\n-DOCSTART- O\n\nRevered O\nskull O\nof O\nS. B-LOC\nAfrica I-LOC\nking O\nis O\nScottish B-MISC\nwoman O\n's O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-24 O\n\nA O\nlimelight-loving O\nSouth B-MISC\nAfrican I-MISC\nchief O\nwas O\nin O\ndisgrace O\non O\nSaturday O\nafter O\na O\nprized O\nskull O\nhe O\nbrought O\nhome O\nfrom O\nScotland B-LOC\nwas O\nidentified O\nas O\nbelonging O\nnot O\nto O\nhis O\nsacred O\ntribal O\nancestor O\n, O\nbut O\nto O\na O\nmiddle-aged O\nwhite O\nwoman O\n. O\n\nA O\nforensic O\nscientist O\nwho O\nexamined O\nthe O\nsupposed O\nskull O\nof O\n19th O\ncentury O\nKing O\nHintsa B-PER\n, O\na O\nchief O\nof O\nPresident O\nNelson B-PER\nMandela I-PER\n's O\nXhosa B-MISC\ntribe O\nkilled O\nin O\nbattle O\nby O\nthe O\nBritish B-MISC\n, O\nsaid O\nit O\nwas O\nin O\nfact O\nthe O\ncranium O\nof O\na O\nEuropean B-MISC\nwoman O\n. O\n\nChief O\nNicholas B-PER\nGcaleka I-PER\n, O\ndressed O\nin O\nanimal O\nskins O\nand O\nfull O\ntribal O\nregalia O\n, O\njourneyed O\nto O\na O\nwintry O\nScotland B-LOC\nin O\nFebruary O\non O\na O\nhugely O\npublicised O\nquest O\nto O\nfind O\nHintsa B-PER\n's O\nskull O\n. O\n\nThe O\nwitchdoctor O\nsaid O\nancestors O\nhad O\nappeared O\nto O\nhim O\nin O\na O\ndream O\nand O\nordered O\nhim O\nto O\nreturn O\nthe O\nhead O\n, O\nsaid O\nto O\nhave O\nbeen O\ncarried O\noff O\nas O\na O\ncolonial O\ntrophy O\nby O\nthe O\nofficer O\nwho O\nshot O\nand O\nallegedly O\nbeheaded O\nHintsa B-PER\nafter O\na O\nbattle O\nin O\n1835 O\n. O\n\nBut O\nGcaleka B-PER\nran O\ninto O\ntrouble O\nas O\nsoon O\nas O\nhe O\nreturned O\nto O\nSouth B-LOC\nAfrica I-LOC\nwith O\na O\nskull O\nhe O\nfound O\nin O\na O\ncottage O\nin O\na O\nlonely O\nHighland B-LOC\nforest O\nnear O\nInverness B-LOC\n. O\n\nHe O\nsaid O\nthe O\nspirit O\nof O\na O\nhurricane O\nhad O\nguided O\nhim O\nthere O\n. O\n\nMembers O\nof O\nthe O\nXhosa B-MISC\nroyal O\nfamily O\n, O\nbranding O\nGcaleka B-PER\na O\ncharlatan O\n, O\nconfiscated O\nthe O\nhead O\nand O\nsent O\nit O\nfor O\ntests O\nto O\na O\nforensic O\nscientist O\n, O\nwho O\nexamined O\nthe O\nshape O\nof O\nthe O\nskull O\nand O\nthe O\nhole O\nthat O\nhe O\ndetermined O\nhad O\nnot O\ncome O\n, O\nas O\nsupposed O\n, O\nfrom O\na O\nbullet O\n. O\n\n\" O\nIt O\ncan O\nbe O\nstated O\nbeyond O\nreasonable O\ndoubt O\nthat O\nthis O\nskull O\nis O\nnot O\nthat O\nof O\nthe O\nlate O\nking O\n, O\n\" O\nthe O\nscientist O\nsaid O\nin O\na O\nstatement O\n. O\n\n-DOCSTART- O\n\nSudan B-LOC\narrests O\nopposition O\nsewing O\nmachine O\nsmugglers O\n. O\n\nKHARTOUM B-LOC\n1996-08-24 O\n\nSudanese B-MISC\npolice O\nhave O\narrested O\nthree O\npeople O\ntrying O\nto O\nsmuggle O\nsewing O\nmachines O\nand O\narmy O\nclothing O\nto O\nSudanese B-MISC\nopposition O\ngroups O\nin O\nEritrea B-LOC\n, O\nan O\nofficial O\nnewspaper O\nreported O\non O\nSaturday O\n. O\n\nThe O\ngovernment-owned O\nal-Ingaz B-ORG\nal-Watani I-ORG\nsaid O\nthe O\nsmugglers O\nwere O\ncaught O\nin O\nBanat B-LOC\nin O\nthe O\neastern O\nstate O\nof O\nKassala B-LOC\n, O\non O\nthe O\nborder O\nwith O\nEritrea B-LOC\n, O\nand O\nhad O\nconfessed O\nthey O\nwere O\non O\ntheir O\nway O\nto O\n\" O\nthe O\nso-called O\nalliance O\nforces O\nwhich O\nhave O\nbeen O\nundertaking O\nsubversive O\noperations O\non O\nthe O\neastern O\nborder O\n\" O\n. O\n\nAuthorities O\nin O\nKassala B-LOC\nsaid O\nopposition O\nforces O\nbased O\nin O\nEritrea B-LOC\nhave O\nbeen O\nlaying O\nlandmines O\nand O\nstealing O\nvehicles O\nand O\nother O\ngoods O\nto O\nsmuggle O\nthem O\nacross O\nthe O\nborder O\ninto O\nEritrea B-LOC\n. O\n\nSudan B-LOC\naccuses O\nthe O\nEritrean B-MISC\nauthorities O\nof O\nproviding O\nsupport O\nto O\nSudanese B-MISC\nopposition O\nelements O\nbased O\nin O\nEritrea B-LOC\n. O\n\nEritrea B-LOC\ncut O\ndiplomatic O\nties O\nwith O\nSudan B-LOC\nin O\n1994 O\n, O\naccusing O\nit O\nof O\ntraining O\nrebels O\nto O\nmake O\nraids O\ninto O\nEritrea B-LOC\n. O\n\nThe O\nexiled O\nNational B-ORG\nDemocratic I-ORG\nAlliance I-ORG\n, O\na O\nSudanese B-MISC\numbrella O\nopposition O\ngroup O\n, O\nhas O\nits O\nheadquarters O\nin O\nthe O\nEritrean B-MISC\ncapital O\nAsmara B-LOC\n. O\n\nIt O\nuses O\nthe O\nformer O\nSudanese B-MISC\nembassy O\n. O\n\n-DOCSTART- O\n\nAlbanian B-MISC\nSocialists O\nstart O\nlandmark O\nreform O\ncongress O\n. O\n\nTIRANA B-LOC\n1996-08-24 O\n\nAlbania B-LOC\n's O\nopposition O\nSocialist B-ORG\nParty I-ORG\nbegan O\na O\ntwo-day O\ncongress O\non O\nSaturday O\nto O\ndiscuss O\nmajor O\njettisoning O\nits O\nlinks O\nwith O\nalmost O\nhalf O\na O\ncentury O\nof O\nStalinist B-MISC\ndictatorship O\nin O\nthe O\nBalkan B-LOC\ncountry O\n. O\n\n\" O\nThe O\ncongress O\nwill O\napprove O\nnew O\nconcepts O\nthat O\nwill O\nturn O\nthe O\nparty O\ninto O\na O\nSocial-Democratic O\nand O\nelectoral O\nparty O\n, O\nnot O\na O\nclass O\nand O\nideological O\none O\n, O\n\" O\nthe O\nSocialist O\nZeri B-ORG\ni I-ORG\nPopullit I-ORG\ndaily O\nsaid O\nin O\nan O\neditorial O\n. O\n\nJailed O\nSocialist O\nleader O\nFatos B-PER\nNano I-PER\nmade O\nthe O\nfirst O\ncall O\nfor O\nchange O\nin O\nJuly O\n, O\na O\nmonth O\nafter O\nthe O\nparty O\n's O\nchief O\nopponents O\n, O\nthe O\nconservative O\nDemocrats B-MISC\nof O\nPresident O\nSali B-PER\nBerisha I-PER\n, O\nalmost O\nswept O\nthe O\nboard O\nin O\na O\ndisputed O\ngeneral O\nelection O\n. O\n\nThe O\nSocialists O\n, O\nreformed O\nheirs O\nto O\nthe O\ncommunists O\n, O\npulled O\nout O\nof O\nthe O\npoll O\nsaying O\nit O\nwas O\na O\nsham O\n. O\n\nActing O\nSocialist O\nleader O\nServet B-PER\nPellumbi I-PER\nhas O\nsaid O\nhe O\ntoo O\nwill O\nurge O\nthe O\nparty O\nto O\nscrap O\nthe O\nideas O\nof O\nKarl B-PER\nMarx I-PER\nat O\nthe O\ncongress O\n. O\n\nThe O\npro-reform O\nstance O\nof O\nsome O\nof O\nthe O\nparty O\nleadership O\ninitially O\ncaused O\na O\nstorm O\nand O\ntriggered O\nthe O\nresignation O\nlast O\nmonth O\nof O\nthe O\nparty O\n's O\nSecretary-General O\nGramoz B-PER\nRuci I-PER\n. O\n\nMore O\nrecently O\npolitical O\ncommentators O\nhave O\nreported O\na O\ngrowing O\nconsensus O\n, O\nhowever O\n, O\nand O\na O\nrift O\nat O\nthe O\nmeeting O\nlooks O\nincreasingly O\nunlikely O\n. O\n\n-DOCSTART- O\n\nNicaraguan B-MISC\npresident O\nto O\ngo O\nto O\nU.S. B-LOC\nfor O\nmedical O\ncare O\n. O\n\nMANAGUA B-LOC\n, O\nNicaragua B-LOC\n1996-08-23 O\n\nNicaraguan B-MISC\nPresident O\nVioleta B-PER\nChamorro I-PER\nwas O\ndue O\nto O\nfly O\nto O\nthe O\nUnited B-LOC\nStates I-LOC\non O\nSaturday O\nfor O\na O\nmedical O\ncheck-up O\nto O\ndetermine O\nif O\nsurgery O\nwas O\nneeded O\non O\nthe O\nlower O\npart O\nof O\nher O\nspinal O\ncolumn O\n, O\nthe O\ngovernment O\nsaid O\non O\nFriday O\n. O\n\nChamorro B-PER\nhas O\ncomplained O\nof O\nlower O\nback O\npain O\nsince O\nher O\ntrip O\nto O\nTaiwan B-LOC\nin O\nMay O\n, O\nwhen O\nthe O\npain O\nforced O\nher O\nto O\ngo O\nto O\nTaipei B-LOC\nUniversity I-LOC\nHospital I-LOC\nfor O\nan O\nexamination O\n. O\n\nChamorro B-PER\n, O\n66 O\n, O\nsuffers O\nfrom O\nosteoporosis O\n, O\na O\ndisease O\nthat O\nweakens O\nthe O\nbones O\n, O\nand O\nhas O\nrepeatedly O\nflown O\nto O\nWashington B-LOC\nfor O\ntreatment O\nby O\nher O\nlongtime O\ndoctor O\n, O\nSam B-PER\nWilson I-PER\n. O\n\n-DOCSTART- O\n\nNepal B-LOC\nwo O\nn't O\nhelp O\nsplit O\nTibet B-LOC\n, O\nking O\ntells O\nChina B-LOC\n. O\n\nBEIJING B-LOC\n1996-08-24 O\n\nKing O\nBirendra B-PER\nof O\nNepal B-LOC\nhas O\ntold O\nChina B-LOC\nhis O\nnation O\nwill O\nnot O\nbecome O\nthe O\ntool O\nof O\npeople O\nwho O\nwant O\nTibetan B-MISC\nindependence O\nfrom O\nBeijing B-LOC\n, O\nthe O\nofficial O\nChina B-ORG\nDaily I-ORG\nnewspaper O\nsaid O\non O\nSaturday O\n. O\n\nKing O\nBirendra B-PER\n, O\nin O\nTibet B-LOC\nat O\nthe O\nstart O\nof O\na O\none-week O\nunofficial O\nvisit O\nto O\nChina B-LOC\n, O\nsaid O\nthe O\nNepalese B-MISC\ngovernment O\nhad O\n\" O\nmaintained O\na O\nsharp O\nvigilance O\nagainst O\nsuch O\nintentions O\n\" O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nNepal B-LOC\nshares O\na O\nlong O\nmountain O\nborder O\nwith O\nthe O\nrestive O\nHimalayan B-MISC\nregion O\n, O\nwhere O\nopposition O\nto O\nBeijing B-LOC\n's O\nfour-decade O\nrule O\nis O\nwidespread O\n. O\n\nChinese B-MISC\nofficial O\nmedia O\nhas O\noften O\naccused O\nforeign O\nforces O\n, O\nnotably O\nthe O\nUnited B-LOC\nStates I-LOC\n, O\nof O\nseeking O\nto O\nsupport O\nTibetan B-MISC\nindependence O\nactivists O\n. O\n\nKing O\nBirenda B-PER\ntold O\nGyaicain B-PER\nNorbu I-PER\n, O\nchairman O\nof O\nthe O\nTibetan B-MISC\ngovernment O\n, O\nthat O\nNepal B-LOC\nwould O\nnot O\n\" O\nbecome O\na O\ntool O\nfor O\nothers O\nto O\nsplit O\nTibet B-LOC\n\" O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nGyaicain B-PER\ntold O\nthe O\nroyal O\nvisitor O\nincreased O\ncooperation O\nbetween O\nNepal B-LOC\nand O\nTibet B-LOC\nwas O\npossible O\nin O\nthe O\nfields O\nof O\ntrade O\n, O\ntourism O\n, O\ncommunications O\nand O\nsports O\n, O\nit O\nsaid O\n. O\n\nIt O\ngave O\nno O\ndetails O\n. O\n\n-DOCSTART- O\n\nIran B-LOC\nhangs O\ntwo O\nmen O\nfor O\ndrug O\ntrafficking O\n. O\n\nTEHRAN B-LOC\n1996-08-24 O\n\nIran B-LOC\nhas O\nhanged O\ntwo O\ndrug O\ntraffickers O\nin O\nthe O\nsouthern O\ncity O\nof O\nShiraz B-LOC\n, O\nthe O\nevening O\nnewspaper O\nResalat B-ORG\nreported O\non O\nSaturday O\n. O\n\nThe O\ntwo O\nIranian B-MISC\nmen O\nwere O\narrested O\nin O\nJuly O\nwith O\n419 O\nkilograms O\n( O\n924 O\nlbs O\n) O\nof O\nopium O\nafter O\nthey O\nopened O\nfire O\non O\npolice O\nand O\nkilled O\na O\npedestrain O\nand O\nwounded O\nfour O\n, O\nthe O\nnewspaper O\nquoted O\na O\npolice O\ncommander O\nas O\nsaying O\n. O\n\nResalat B-ORG\nsaid O\nthe O\nexecutions O\nwere O\nordered O\nby O\nthe O\nIslamic B-ORG\nRevolutionary I-ORG\nCourt I-ORG\n. O\n\nIt O\ndid O\nnot O\nsay O\nwhen O\nthey O\ntook O\nplace O\n. O\n\nOne O\nof O\nthe O\nmen O\n, O\nwho O\nkilled O\nthe O\npedestrian O\n, O\nwas O\nhanged O\nat O\nthe O\nsite O\nof O\nthe O\ncrime O\nand O\nthe O\nother O\nwas O\nexecuted O\nin O\nAdel B-LOC\nprison O\nin O\nShiraz B-LOC\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nPossession O\nof O\n30 O\ngrammes O\n( O\njust O\nover O\nan O\nounce O\n) O\nof O\nheroin O\nor O\nfive O\nkg O\n( O\n11 O\nlb O\n) O\nof O\nopium O\nis O\npunishable O\nby O\ndeath O\nin O\nIran B-LOC\n. O\n\nMore O\nthan O\n1,000 O\npeople O\nhave O\nbeen O\nexecuted O\nin O\ndrug-related O\ncases O\nsince O\nthe O\nlaw O\ntook O\neffect O\nin O\n1989 O\n. O\n\nIran B-LOC\nhas O\nan O\nestimated O\none O\nmillion O\ndrug O\naddicts O\nand O\nis O\na O\nkey O\ntransit O\nroute O\nfor O\ndrugs O\n, O\nmostly O\nopium O\n, O\nsmuggled O\nto O\nEurope B-LOC\nthrough O\nAfghanistan B-LOC\nand O\nPakistan B-LOC\n-- O\nthe O\nso O\ncalled O\n\" O\nGolden B-ORG\nCrescent I-ORG\n. O\n\" O\n\n-DOCSTART- O\n\nMain O\nTunisian B-MISC\nopposition O\nparty O\nousted O\nfrom O\nHQ O\n. O\n\nTUNIS B-LOC\n1996-08-24 O\n\nTunisia B-LOC\n's O\nmain O\nopposition O\nparty O\non O\nSaturday O\nannounced O\nthat O\nit O\nhad O\nbeen O\nousted O\nfrom O\nits O\nheadquarters O\nbuilding O\nby O\na O\ncourt O\ndecision O\nfor O\nfailing O\nto O\npay O\nthe O\nrent O\n. O\n\nMohamed B-PER\nAli I-PER\nKhalfallah I-PER\n, O\nspokesman O\nfor O\nthe O\nMovement B-ORG\nof I-ORG\nSocialist I-ORG\nDemocrats I-ORG\n( O\nMDS B-ORG\n) O\nsaid O\nthat O\na O\nbailiff O\nwho O\nwas O\naccompagnied O\nby O\npolicemen O\n, O\non O\nSaturday O\nordered O\nthe O\nparty O\nto O\nleave O\nthe O\nbuilding O\n. O\n\n\" O\nWe O\nwere O\nnot O\nallowed O\na O\ndelay O\nto O\nenable O\nus O\nto O\ntransfer O\nthe O\nmovement O\n's O\ngoods O\nand O\ndocuments O\n, O\n\" O\nKhalfallah B-PER\nadded O\nin O\na O\nstatement O\n. O\n\nThe O\nbuilding O\nis O\nstate O\nproperty O\n. O\n\nThe O\nMDS B-ORG\nwas O\nrepresented O\nin O\ncourt O\nand O\nadmitted O\nowing O\nmoney O\nfor O\nrent O\nbut O\ndid O\nnot O\ngive O\ndetails O\n. O\n\nMDS B-ORG\nthis O\nyear O\nlost O\nits O\npresident O\nand O\nvice-president O\n, O\nboth O\nof O\nwhom O\nwere O\ntried O\nand O\ngiven O\njail O\nsentences O\n. O\n\nMDS B-ORG\npresident O\nMohamed B-PER\nMoada I-PER\nwas O\nsentenced O\nlast O\nFebruary O\nto O\n11 O\nyears O\nin O\njail O\non O\ncharges O\nof O\nhaving O\nsecret O\ncontacts O\nwith O\nLibyan B-MISC\nagents O\nand O\nreceiving O\nmoney O\nfrom O\nTripoli B-LOC\n. O\n\nVice-president O\nKhemais B-PER\nChammari I-PER\nlast O\nJuly O\nwas O\nsentenced O\nto O\nfive O\nyears O\nin O\nprison O\non O\na O\ncharge O\nof O\ndisclosing O\nsecrets O\nof O\njudicial O\nproceedings O\nin O\nMoada B-PER\n's O\naffair O\n. O\n\nTo O\nreplace O\nMoada B-PER\n, O\nthe O\nMDS B-ORG\nafter O\nthe O\ntrial O\nnamed O\nKhalfallah B-PER\nas O\n\" O\ncoordinator O\n\" O\nbut O\nIsmail B-PER\nBoulahya I-PER\n, O\nthe O\nlast O\nof O\nthe O\nMDS B-ORG\nfounding O\nmembers O\nstill O\npolitically O\nactive O\n, O\nclaimed O\nthe O\ntitle O\nof O\npresident O\n, O\ncausing O\na O\nnew O\nsplit O\nwithin O\nthe O\nmovement O\n. O\n\nMDS B-ORG\nwas O\nfounded O\nin O\n1978 O\nby O\na O\ngroup O\nled O\nby O\nAhmed B-PER\nMestiri I-PER\n, O\nwho O\nwithdrew O\nfrom O\npolitics O\nin O\n1992 O\n. O\n\nSucceeding O\nhim O\nas O\nhead O\nof O\nthe O\nmovement O\n, O\nMoada B-PER\n, O\nan O\nArab B-MISC\nnationalist O\n, O\nousted O\nliberals O\nled O\nby O\nMDS B-ORG\nsecretary-general O\nMustapha B-PER\nBen I-PER\nJaafar I-PER\nin O\n1993 O\n. O\n\n-DOCSTART- O\n\nKurdish B-MISC\ngroup O\nsays O\ntwo O\nkilled O\nin O\nIraqi B-MISC\nshelling O\n. O\n\nNICOSIA B-LOC\n1996-08-24 O\n\nAn O\nIraqi B-MISC\nKurdish I-MISC\nguerrilla O\ngroup O\non O\nSaturday O\naccused O\nIraqi B-MISC\ngovernment O\nforces O\nof O\nkilling O\ntwo O\ncivilians O\nin O\nshelling O\nin O\nnorthern O\nIraq B-LOC\n, O\nthe O\nIranian B-MISC\nnews O\nagency O\nIRNA B-ORG\nreported O\n. O\n\nIRNA B-ORG\nsaid O\nit O\nwas O\nmonitoring O\na O\nreport O\nfrom O\na O\nradio O\nstation O\naffiliated O\nto O\nthe O\nPatriotic B-ORG\nUnion I-ORG\nof I-ORG\nKurdistan I-ORG\n( O\nPUK B-ORG\n) O\n. O\n\n\" O\nIraqi B-MISC\narmy O\nheavily O\nshelled O\nthe O\nKanie B-LOC\nKarzhala I-LOC\ncamp O\n, O\nwest O\nof O\nArbil B-LOC\n, O\non O\nFriday O\n... O\n\nTwo O\ncivilians O\nwere O\nkilled O\nin O\nthe O\nIraqi B-MISC\nbombing O\n, O\n\" O\nIRNA B-ORG\nquoted O\nthe O\nradio O\nreport O\nas O\nsaying O\n. O\n\nThe O\nPUK-run B-MISC\nradio O\non O\nFriday O\nsaid O\nIraqi B-MISC\nheavy O\nartillery O\nwas O\npounding O\nits O\npositions O\nin O\nKurdish-controlled B-MISC\nnorthern O\nIraq B-LOC\nbut O\nit O\ngave O\nno O\ndetails O\nof O\ncasualties O\n. O\n\nThere O\nwas O\nno O\nindependent O\nconfirmation O\nof O\nthe O\nreports O\n. O\n\nThe O\nrival O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nKDP B-ORG\n) O\n, O\nwhich O\naccuses O\nIran B-LOC\nof O\nsupporting O\nthe O\nPUK B-ORG\n, O\nsaid O\non O\nThursday O\nthat O\nits O\nforces O\nhad O\nhalted O\nan O\nIranian-backed O\nattack O\nby O\nthousands O\nof O\nPUK B-ORG\nfighters O\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\nsaid O\nin O\nWashington B-LOC\non O\nFriday O\nthat O\nit O\nhad O\nbrokered O\na O\nceasefire O\nto O\nend O\nsix O\ndays O\nof O\nfighting O\nbetween O\nthe O\ntwo O\nmain O\nKurdish B-MISC\nfactions O\nand O\npersuaded O\nthem O\nto O\nattend O\nU.S.-mediated B-MISC\npeace O\ntalks O\nnext O\nmonth O\n. O\n\nThe O\nclashes O\n, O\nshattering O\na O\nceasefire O\nnegotiated O\nlast O\nyear O\nby O\nWashington B-LOC\n, O\nhad O\nthreatened O\na O\nU.S.-led B-MISC\npeace O\nplan O\nto O\nunite O\nthe O\nKurdish B-MISC\nregion O\nagainst O\nIraqi B-MISC\nPresident O\nSaddam B-PER\nHussein I-PER\n. O\n\nU.S. B-LOC\n, O\nBritish B-MISC\nand O\nFrench B-MISC\nplanes O\nhave O\nbeen O\npatrolling O\nthe O\nskies O\nof O\nnorthern O\nIraq B-LOC\nsince O\nshortly O\nafter O\nthe O\n1991 O\nGulf B-MISC\nWar I-MISC\nto O\nshield O\nIraq B-LOC\n's O\nKurds B-MISC\nfrom O\nany O\nattack O\nby O\nIraqi B-MISC\ntroops O\n. O\n\n-DOCSTART- O\n\nIran B-LOC\naccuses O\nIraq B-LOC\nof O\nceasefire O\nviolations O\n. O\n\nNICOSIA B-LOC\n1996-08-24 O\n\nIran B-LOC\nhas O\naccused O\nIraq B-LOC\nof O\nviolating O\nthe O\nceasefire O\nending O\ntheir O\n1980-88 O\nwar O\nsome O\n32 O\ntimes O\nbetween O\nthe O\nend O\nof O\nMarch O\nand O\nMay O\n31 O\nthis O\nyear O\n, O\nthe O\nIranian B-MISC\nnews O\nagency O\nIRNA B-ORG\nreported O\non O\nSaturday O\n. O\n\nIran B-LOC\n's O\ndeputy O\nrepresentative O\nto O\nthe O\nUnited B-ORG\nNations I-ORG\n, O\nMajid B-PER\nTakht I-PER\nRavanchi I-PER\n, O\nmade O\nthe O\nallegations O\nin O\na O\nletter O\nto O\nU.N. B-ORG\nSecretary-General O\nBoutros B-PER\nBoutros-Ghali I-PER\non O\nFriday O\n, O\nthe O\nagency O\nsaid O\n. O\n\n\" O\nThe O\nIslamic B-LOC\nRepublic I-LOC\nof I-LOC\nIran I-LOC\nhas O\nreported O\nsome O\n32 O\nnew O\ncases O\nof O\nceasefire O\nviolations O\nby O\nthe O\nIraqi B-MISC\nregime O\nbetween O\nMarch O\n31 O\nand O\nMay O\n31 O\n, O\n1996 O\n, O\n\" O\nit O\nreported O\nfrom O\nNew B-LOC\nYork I-LOC\n. O\n\nIt O\nsaid O\nviolations O\nincluded O\nconstructing O\nobservation O\nposts O\n, O\ninstalling O\nmortars O\nand O\nanti-aircraft O\ncannons O\n, O\nsetting O\nup O\ntents O\n, O\npenetrating O\nIranian B-MISC\nterritory O\n, O\nand O\nfiring O\nrifle O\ngrenades O\ntowards O\nIranian B-MISC\nterritory O\n. O\n\nThe O\neight-year O\nwar O\nbetween O\nthe O\ntwo O\ncountries O\nended O\nwith O\na O\nU.N.-sponsored B-MISC\nceasefire O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nIraq B-LOC\n- O\nAug O\n24 O\n. O\n\nBAGHDAD B-LOC\n1996-08-24 O\n\nThese O\nare O\nsome O\nof O\nthe O\nleading O\nstories O\nin O\nthe O\nofficial O\nIraqi B-MISC\npress O\non O\nSaturday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nJUMHOURIYA B-ORG\n\n- O\nIstanbul B-LOC\nchamber O\nof O\ncommerce O\nurges O\nAnkara B-LOC\nto O\nresume O\ntrade O\nwith O\nIraq B-LOC\n. O\n\n- O\nOffers O\nfrom O\nArab B-MISC\nand O\nforeign O\ncompanies O\nto O\nsupply O\nIraq B-LOC\nwith O\ngoods O\n. O\n\n- O\nFour O\nships O\nunload O\ntonnes O\nof O\nIraq-bound B-MISC\nsugar O\nat O\nJordan B-LOC\n's O\nAqaba B-LOC\n. O\n\n- O\nEditorial O\nblames O\nU.S. B-LOC\nfor O\nlatest O\nflare-up O\nof O\nfighting O\nbetween O\nKurdish B-MISC\nrebels O\nin O\nnorthern O\nIraq B-LOC\n. O\n\n- O\nBlack O\nmarket O\nbooms O\nin O\nthe O\nshadow O\nof O\nstate-run O\nsupermarkets O\n. O\n\n- O\nParliament O\ncompletes O\ndraft O\nlaw O\non O\nprotection O\nof O\nriver O\nwaters O\nin O\nIraq B-LOC\n. O\n\nQADISSIYA B-ORG\n\n- O\nIraq B-LOC\ndenounces O\nviolation O\nof O\nairspace O\nby O\nU.S. B-LOC\nwarplanes O\n. O\n\nIRAQ B-LOC\n\n- O\nEditorial O\nlambasts O\nJalal B-PER\nTalabani I-PER\n, O\nleader O\nof O\na O\nKurdish B-MISC\nrebel O\nfaction O\nin O\nthe O\nnorth O\n, O\nfor O\nliaising O\nwith O\nIran B-LOC\nin O\nits O\nfight O\nagainst O\nrivals O\n. O\n\nBABEL B-ORG\n\n- O\nBlaming O\nIraq B-LOC\nfor O\nriots O\nin O\nJordan B-LOC\nis O\na O\ndirty O\ngame O\n. O\n\n-DOCSTART- O\n\nClinton B-PER\ncampaign O\nbusy O\nmaking O\n\" O\nnews O\n\" O\n. O\n\nLaurence B-PER\nMcQuillan I-PER\n\nWASHINGTON B-LOC\n1996-08-24 O\n\nPresident O\nBill B-PER\nClinton I-PER\nhas O\nserved O\nnotice O\nhe O\nintends O\nto O\nbe O\nbusy O\n\" O\nmaking O\nnews O\n\" O\n-- O\nor O\nat O\nleast O\ndoing O\nthings O\nthat O\nlook O\nand O\nsound O\nlike O\nit O\nin O\na O\ncampaign O\nyear O\n. O\n\nWith O\nDemocrats B-MISC\ngathering O\nin O\nChicago B-LOC\nto O\nstart O\na O\nconvention O\non O\nMonday O\nto O\nnominate O\nhim O\nfor O\na O\nsecond O\nterm O\nas O\npresident O\n, O\nClinton B-PER\nplans O\na O\nsteady O\nparade O\nof O\nevents O\ndesigned O\nto O\nhighlight O\nhis O\nleadership O\nand O\ndim O\nthe O\nglow O\nof O\nthe O\njust-concluded O\nRepublican B-MISC\nconclave O\nthat O\ngave O\na O\nboost O\nto O\nrival O\nBob B-PER\nDole I-PER\n. O\n\nAfter O\na O\nweek O\nof O\ncarefully O\norchestrated O\nevents O\nsigning O\ninto O\nlaw O\nbills O\npassed O\nby O\nthe O\nRepublican-controlled B-MISC\nCongress B-ORG\n, O\nClinton B-PER\nused O\nhis O\nSaturday O\nradio O\naddress O\nto O\nthe O\nnation O\nto O\nproudly O\n\" O\nannounce O\n\" O\na O\ndevelopment O\nin O\nthe O\nwar O\non O\ncrime O\n. O\n\n\" O\nSixty O\ndays O\nago O\nI O\ndirected O\nthe O\nattorney O\ngeneral O\nto O\ndraw O\nup O\na O\nplan O\nfor O\na O\nnational O\nregistry O\nof O\nsex O\noffenders O\n, O\n\" O\nClinton B-PER\nsaid O\n. O\n\" O\n\nThat O\nplan O\nhas O\nnow O\nreached O\nmy O\ndesk O\n. O\n\" O\n\n\" O\nToday O\nI O\nam O\npleased O\nto O\nannounce O\nthat O\nwe O\nare O\nfollowing O\nthrough O\non O\nour O\ncommitment O\nto O\nkeep O\ntrack O\nof O\nthese O\ncriminals O\n, O\nnot O\njust O\nin O\na O\nsingle O\nstate O\nbut O\nwherever O\nthey O\ngo O\n, O\n\" O\nhe O\nsaid O\n. O\n\nActually O\n, O\ncreation O\nof O\nsuch O\na O\nregistry O\nwas O\nunderway O\nwithout O\nClinton B-PER\nlifting O\na O\nfinger O\n. O\n\nAttorney O\nGeneral O\nJanet B-PER\nReno I-PER\n's O\nreport O\n-- O\nall O\nnine O\npages O\nof O\nit O\n, O\nincluding O\nfootnotes O\n-- O\noffers O\nonly O\nthe O\ninterim O\nservices O\nof O\nthe O\nFBI B-ORG\nuntil O\na O\nformal O\nregistry O\non O\nsex O\noffenders O\nhas O\nbeen O\nestablished O\n. O\n\nTwo O\nmonths O\nago O\n, O\nClinton B-PER\nannounced O\nhe O\nwanted O\nan O\ninterim O\neffort O\nestablished O\n. O\n\nNow O\n, O\n60 O\ndays O\nlater O\n, O\nhe O\nhad O\na O\nchance O\nto O\ntalk O\nabout O\nit O\nagain O\n. O\n\nIt O\nis O\nan O\nexample O\nof O\nClinton B-PER\n's O\nstrategic O\nplanning O\nas O\nhe O\nheads O\ninto O\nthe O\nstretch O\ndrive O\nfor O\nthe O\nNov. O\n5 O\npresidential O\nelection O\n. O\n\nSuch O\nthings O\ndo O\nnot O\nhappen O\nby O\nchance O\nin O\nthe O\nClinton B-PER\nWhite B-LOC\nHouse I-LOC\n, O\nthey O\nare O\npart O\nof O\nhis O\npolitical O\nchess O\ngame O\n. O\n\nIn O\nthe O\npast O\nweek O\nClinton B-PER\nsigned O\ninto O\nlaw O\nan O\nincrease O\nin O\nthe O\nminimium O\nwage O\n, O\na O\nbill O\nthat O\nmakes O\nit O\neasier O\nfor O\nsomeone O\nwith O\na O\npre-existing O\nhealth O\nproblem O\nto O\nchange O\njobs O\n, O\nand O\nsweeping O\nchanges O\noverhauling O\nthe O\nnation O\n's O\nwelfare O\nsystem O\n. O\n\n\" O\nAmerica B-LOC\ncan O\nlook O\nback O\non O\na O\nweek O\nof O\nremarkable O\nachievement O\n, O\n\" O\nClinton B-PER\nsaid O\n, O\nwithout O\neven O\na O\npassing O\nreference O\nto O\nthe O\nRepublican B-MISC\nmajority O\nin O\nthe O\nHouse B-ORG\nand O\nSenate B-ORG\n. O\n\n\" O\nAmerica B-LOC\nis O\non O\nthe O\nright O\ntrack O\noffering O\nmore O\nopportunity O\n, O\ndemanding O\nmore O\nresponsibility O\n, O\nbuilding O\na O\nstronger O\ncommunity O\n, O\nthe O\nsense O\nof O\nshared O\nvalues O\nand O\nstronger O\nfamilies O\n, O\n\" O\nhe O\nsaid O\nin O\nstriking O\nthe O\ntheme O\nof O\nhis O\ncoming O\nweek O\n. O\n\nAccording O\nto O\na O\nsenior O\ncampaign O\nofficial O\n, O\nClinton B-PER\n\" O\nwill O\nbe O\nmaking O\na O\nlot O\nof O\nnews O\nin O\nthe O\ncoming O\nweek O\n-- O\nsomething O\ndifferent O\neach O\nday O\n. O\n\" O\n\nClinton B-PER\ndeparts O\non O\nSunday O\non O\na O\nfour-day O\ntrain O\ntrip O\nthrough O\nWest B-LOC\nVirginia I-LOC\n, O\nKentucky B-LOC\n, O\nOhio B-LOC\n, O\nMichigan B-LOC\nand O\nIndiana B-LOC\nwhile O\nfellow O\nDemocrats B-MISC\nare O\ngathered O\nin O\nChicago B-LOC\n. O\n\n\" O\nHe O\n'll O\nmake O\nnews O\nduring O\nthe O\nday O\n... O\nand O\nthen O\nat O\nnight O\nthe O\nattention O\nwill O\ngo O\nto O\nthe O\nconvention O\n, O\n\" O\nsaid O\nthe O\ncampaign O\nofficial O\n. O\n\" O\n\nWe O\nthink O\nit O\n'll O\nwork O\nreally O\nwell O\n. O\n\" O\n\nAlthough O\nofficials O\ndecline O\nto O\nsay O\njust O\nwhat O\neach O\nday O\n's O\n\" O\nnews O\n\" O\nwill O\nbe O\n, O\nthe O\nintent O\nis O\nto O\nput O\na O\nfocus O\non O\nClinton B-PER\nhimself O\nand O\nnot O\njust O\nthose O\nattending O\nthe O\nparty O\n's O\nconvention O\n. O\n\nEach O\nday O\nof O\nthe O\ntrip O\nwill O\nhave O\na O\nlate O\nstart O\n, O\nso O\nthat O\nnetwork O\ntelevision O\ncorrespondents O\nwill O\nbe O\nable O\nto O\ndo O\nlive O\nreports O\nfor O\nmorning O\nprogrammes O\n. O\n\nCampaign O\nofficials O\nthen O\nhope O\nthe O\nday O\n's O\n\" O\nnews O\n\" O\nevent O\nwill O\nbe O\nshowcased O\non O\nevening O\ntelevision O\nnews O\nshows O\nas O\na O\nlead-in O\nfor O\nthat O\nnight O\n's O\nconvention O\nprogramme O\n. O\n\n\" O\nWe O\n'll O\nbe O\nconcentrating O\n... O\non O\nsupporting O\nthe O\npresident O\nas O\nhe O\nis O\non O\nthe O\ntrip O\nand O\nmaking O\nsignificant O\npublic O\npolicy O\nstatements O\nrelated O\nto O\nsome O\nof O\nhis O\nplans O\nfor O\nthe O\nfuture O\n, O\n\" O\nsaid O\nWhite B-LOC\nHouse I-LOC\nPress O\nSecretary O\nMike B-PER\nMcCurry I-PER\n. O\n\nMcCurry B-PER\nsaid O\nthat O\nwhen O\nClinton B-PER\ndelivers O\nhis O\nacceptance O\naddress O\non O\nThursday O\nnight O\nto O\nfellow O\nDemocrats B-MISC\nand O\na O\nnational O\ntelevision O\naudience O\n, O\nhe O\nwill O\n\" O\nset O\nout O\na O\nroad O\nmap O\n\" O\nfor O\nthe O\nnation O\n's O\nfuture O\n-- O\none O\nthe O\npresident O\nhopes O\nguides O\nhim O\nback O\nto O\nthe O\nWhite B-LOC\nHouse I-LOC\nfor O\nfour O\nmore O\nyears O\n. O\n\n-DOCSTART- O\n\nHurricane O\nexpected O\nto O\nveer O\nnorth O\nof O\nCaribbean B-LOC\n. O\n\nMIAMI B-LOC\n1996-08-24 O\n\nHurricane O\nEdouard B-MISC\ngrew O\nstronger O\non O\nSaturday O\nas O\nit O\nswirled O\nacross O\nthe O\nAtlantic B-LOC\nOcean I-LOC\n, O\nbut O\nforecasters O\nat O\nthe O\nNational B-ORG\nHurricane I-ORG\nCenter I-ORG\nsaid O\nthe O\nstorm O\nwould O\nlikely O\nswing O\nnorth O\nand O\nmiss O\nthe O\nCaribbean B-LOC\n. O\n\n\" O\nEdouard B-MISC\nis O\ngetting O\nstronger O\nand O\nstronger O\n, O\nand O\nit O\nalready O\nhas O\nwinds O\nof O\n105 O\nmph O\n( O\n185 O\nkph O\n) O\n, O\n\" O\nsaid O\nhurricane O\nforecaster O\nLixion B-PER\nAvila I-PER\n. O\n\n\" O\nBut O\nthe O\ngood O\nnews O\nis O\nthat O\nall O\nour O\ncomputer O\nmodels O\nindicate O\nEdouard B-MISC\nis O\ngoing O\nto O\nturn O\nto O\nthe O\nwest-northwest O\non O\nSunday O\nand O\nmiss O\nthe O\nislands O\n, O\n\" O\nhe O\nadded O\n. O\n\nAt O\n11 O\na.m. O\nEDT O\n( O\n1500 O\nGMT B-MISC\n) O\n, O\nEdouard B-MISC\nwas O\n1,130 O\nmiles O\neast O\nof O\nthe O\nLesser B-LOC\nAntilles I-LOC\nand O\nmoving O\nwest O\nat O\n14 O\nmph O\n( O\n25 O\nkph O\n) O\n. O\n\nIts O\nexact O\nposition O\nwas O\nlatitude O\n14.5 O\nnorth O\n, O\nlongitude O\n44.2 O\nwest O\n. O\n\n-DOCSTART- O\n\nFrance B-LOC\nhands O\nsuspected O\nETA B-ORG\nmember O\nto O\nSpain B-LOC\n. O\n\nPARIS B-LOC\n1996-08-24 O\n\nFrance B-LOC\non O\nSaturday O\nhanded O\na O\nsuspected O\nmember O\nof O\nthe O\nBasque B-MISC\nseparatist O\ngroup O\nETA B-ORG\nto O\nSpanish B-MISC\nauthorities O\n, O\nFrench B-MISC\nInterior B-ORG\nMinistry I-ORG\nofficials O\nsaid O\n. O\n\nIgnacio B-PER\nOlascoaga I-PER\nMugica I-PER\n, O\nwho O\nhad O\njust O\nended O\na O\nprison O\nsentence O\nin O\nFrance B-LOC\n, O\nis O\nsuspected O\nof O\nhaving O\ntaken O\npart O\nin O\nseveral O\nguerrilla O\nattacks O\nin O\nSpain B-LOC\n. O\n\nETA B-ORG\n( O\nBasque B-ORG\nHomeland I-ORG\nand I-ORG\nFreedom I-ORG\n) O\nhas O\nkilled O\nabout O\n800 O\npeople O\nin O\nits O\ncampaign O\nfor O\nan O\nindependent O\nBasque B-MISC\nstate O\nsince O\nthe O\n1960s O\n. O\n\n-DOCSTART- O\n\nGerman B-MISC\ntroops O\nto O\nremain O\nin O\nBosnia B-LOC\nfor O\n1997--Ruehe B-MISC\n. O\n\nBONN B-LOC\n1996-08-24 O\n\nDefence O\nMinister O\nVolker B-PER\nRuehe I-PER\nsaid O\nthat O\nGerman B-MISC\ntroops O\nwould O\nstay O\non O\nin O\nBosnia B-LOC\nnext O\nyear O\nas O\npart O\nof O\nan O\ninternational O\nforce O\nto O\nensure O\nthe O\nestablishment O\nof O\npeace O\n, O\na O\nnewspaper O\nreported O\non O\nSaturday O\n. O\n\nThe O\ncurrent O\nNATO-led B-MISC\npeace O\nforce O\n( O\nIFOR B-ORG\n) O\nin O\nBosnia B-LOC\nis O\ndue O\nto O\nreturn O\nhome O\nat O\nthe O\nend O\nof O\nthe O\nyear O\n. O\n\nBut O\nRuehe B-PER\ntold O\nBild B-ORG\nam I-ORG\nSonntag I-ORG\nin O\nan O\ninterview O\nthat O\na O\n\" O\nnew O\nand O\ndifferent O\nmandate O\n\" O\nfor O\nthe O\ntroops O\nwould O\nbe O\nagreed O\non O\nfor O\nnext O\nyear O\nafter O\nthe O\ncurrent O\nmandate O\nexpires O\nin O\nDecember O\n. O\n\n\" O\nAfter O\nthe O\n( O\nBosnian B-MISC\n) O\nelections O\n( O\non O\nSeptember O\n14 O\n) O\nthe O\ntroops O\nwill O\nstart O\nbeing O\nreduced O\nfrom O\nthe O\nbeginning O\nof O\nOctober O\nfrom O\n60,000 O\nto O\nabout O\n20,000 O\n. O\n\nA O\ncompletely O\nnew O\nand O\ndifferent O\nmandate O\nwill O\nbe O\nagreed O\nfor O\nnext O\nyear O\n, O\n\" O\nRuehe B-PER\nsaid O\n. O\n\n\" O\nThe O\ndefence O\nministers O\nwill O\nbegin O\nnegotiations O\nfor O\nthis O\nat O\nthe O\nbeginning O\nof O\nSeptember O\nat O\na O\nNATO B-ORG\nmeeting O\n, O\n\" O\nhe O\ntold O\nthe O\nnewspaper O\nin O\nan O\ninterview O\n, O\nexcerpts O\nof O\nwhich O\nwere O\nreleased O\nahead O\nof O\npublication O\non O\nSunday O\n. O\n\n\" O\nBut O\nwe O\nmust O\navoid O\ngiving O\nthe O\nimpression O\nthis O\npeace O\ndeployment O\nin O\nformer O\nYugoslavia B-LOC\nis O\nbeing O\nperceived O\nin O\nthe O\nlong O\nrun O\nas O\nan O\noccupation O\n. O\n\nOn O\nthe O\nother O\nhand O\nwe O\nmust O\nprevent O\nany O\nreturn O\nof O\nwar O\nand O\nmassacres O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nItalian B-MISC\ncomics O\nhope O\nindependence-joke O\n's O\non O\nBossi B-PER\n. O\n\nORVIETO B-LOC\n, O\nItaly B-LOC\n1996-08-24 O\n\nA O\ngroup O\nof O\nItalian B-MISC\ncomics O\nhope O\nthe O\njoke O\nwill O\nbe O\non O\nseparatist O\nleader O\nUmberto B-PER\nBossi I-PER\nnext O\nmonth O\nwhen O\nthey O\nlead O\nthe O\nancient O\nEtruscan B-MISC\ntown O\nof O\nOrvieto B-LOC\nin O\na O\nmock O\nsplit O\nfrom O\nRome B-LOC\n. O\n\nOrvieto B-LOC\nmayor O\nStefano B-PER\nCimicchi I-PER\nsaid O\nthe O\ncomics O\n, O\nincluding O\npopular O\nactor O\nRoberto B-PER\nBenigni I-PER\n, O\nwould O\ndeclare O\nOrvieto B-LOC\n\" O\ncapital O\nof O\nEtruria B-LOC\n\" O\non O\nSeptember O\n15 O\n-- O\nthe O\nday O\nBossi B-PER\nplans O\na O\nmarch O\nacross O\nthe O\nnorth O\nin O\nfavour O\nof O\nindependence O\nfrom O\nRome B-LOC\n. O\n\n\" O\nWe O\nwill O\nthen O\nproceed O\nwith O\nthe O\nannexation O\nof O\nSardinia B-LOC\n, O\nCorsica B-LOC\nand O\nCyprus B-LOC\n, O\n\" O\nCimicchi B-PER\ntold O\nreporters O\non O\nSaturday O\n. O\n\nHe O\nsaid O\nthe O\ncity O\ncouncil O\nwould O\nbe O\n\" O\nironically O\npresent O\n\" O\nwhen O\nthe O\ncomics O\nmade O\ntheir O\nproclamation O\non O\nthe O\nsame O\nday O\nBossi B-PER\nhas O\nthreatened O\nto O\ndeclare O\nthe O\nbirth O\nof O\nPadania B-LOC\n, O\nthe O\nname O\nhe O\nhas O\ngiven O\nto O\nnorthern O\nItaly B-LOC\n. O\n\nOrvieto B-LOC\n, O\nlocated O\nin O\nUmbria B-LOC\nbetween O\nRome B-LOC\nand O\nFlorence B-LOC\n, O\nwas O\nonce O\nthe O\ncapital O\nof O\nEtruria B-LOC\n, O\nan O\nancient O\nfederation O\nof O\n12 O\nEtruscan B-MISC\ntowns O\n. O\n\n\" O\nWe O\nwant O\nto O\npop O\nsome O\nair O\nout O\nof O\nthis O\nballoon O\nof O\ntension O\nthat O\nhas O\nbeen O\nblown O\nup O\naround O\nSeptember O\n15 O\n, O\n\" O\nCimicchi B-PER\nsaid O\n. O\n\n\" O\nWe O\nwant O\nto O\nhelp O\nturn O\ndown O\nthe O\nrhetoric O\nin O\na O\ncountry O\nthat O\nborders O\nformer O\nYugoslavia B-LOC\nyet O\nin O\nwhich O\npeople O\nare O\nstill O\ntalking O\nabout O\nsecession O\n, O\n\" O\nhe O\nadded O\n. O\n\nBossi B-PER\nhas O\nintensified O\nhis O\nseparatist O\nrhetoric O\nsince O\nhis O\nNorthern B-ORG\nLeague I-ORG\nparty O\n's O\ngood O\nshowing O\nin O\nlast O\nApril O\n's O\ngeneral O\nelection O\n, O\nwhen O\nit O\ntook O\n10 O\npercent O\nof O\nthe O\nvote O\nnationally O\n. O\n\nHe O\nhas O\nrecently O\ndropped O\na O\ndrive O\nfor O\nfederalism O\n, O\nsaying O\nsecession O\nfrom O\nRome B-LOC\n's O\nwasteful O\nand O\ncentralised O\nbureaucracy O\nis O\nthe O\nonly O\nsolution O\nfor O\nnortherners O\n. O\n\n-DOCSTART- O\n\nItalian B-MISC\nfarmer O\nsays O\nhe O\nmutilated O\nfour O\nwomen O\n. O\n\nVERONA B-LOC\n, O\nItaly B-LOC\n1996-08-24 O\n\nAn O\nItalian B-MISC\nfarmer O\naccused O\nof O\nmultiple O\nhomocide O\nhas O\nconfessed O\nto O\nmutilating O\nthe O\nbodies O\nof O\nfour O\nwomen O\nafter O\nhaving O\nsex O\nwith O\nthem O\n, O\nthe O\nItalian B-MISC\nnews O\nagency O\nANSA B-ORG\nreported O\non O\nSaturday O\n. O\n\nIt O\nquoted O\nthe O\nlawyer O\nof O\nGianfranco B-PER\nStevanin I-PER\nas O\nsaying O\nthe O\n35-year-old O\nfarmer O\nconfessed O\non O\nFriday O\nto O\na O\nVerona B-LOC\nmagistrate O\nthat O\nhe O\nhad O\nkilled O\nand O\nmutilated O\nthe O\nwomen O\n. O\n\nANSA B-ORG\nsaid O\nStevanin B-PER\nwas O\nunable O\nto O\nrecall O\nhow O\nhe O\nhad O\nkilled O\nthe O\nwomen O\n, O\nremembering O\nonly O\nthat O\nhe O\nhad O\nfound O\nthem O\n\" O\nlifeless O\nin O\nhis O\narms O\n\" O\nafter O\nhaving O\nsadmasochistic O\nsex O\nwith O\nthem O\n. O\n\nStevanin B-PER\n, O\narrested O\nin O\n1994 O\nand O\njailed O\nfor O\nthree O\nyears O\nfor O\nassaulting O\nan O\nAustrian B-MISC\nprostitute O\n, O\nis O\naccused O\nof O\nmurdering O\nfive O\nwomen O\n, O\nthree O\nof O\nwhose O\nbodies O\nwere O\nfound O\nnear O\nhis O\nvilla O\noutside O\nVerona B-PER\nbetween O\nJuly O\nand O\nDecember O\n1995 O\n. O\n\nTwo O\nof O\nthe O\ncorpses O\nwere O\nidentified O\nbut O\nnot O\nthe O\nthird O\n, O\nfound O\nheadless O\nand O\ndecomposed O\nin O\na O\nsack O\nin O\na O\nnearby O\ncanal O\n. O\n\nLawyer O\nCesare B-PER\ndal I-PER\nMaso I-PER\ntold O\nANSA B-ORG\nthat O\nStevanin B-PER\nconfessed O\nto O\nbeheading O\nand O\ndumping O\nthe O\nbody O\nof O\na O\nfourth O\nwoman O\nin O\nthe O\nnearby O\nAdige B-LOC\nriver O\n. O\n\nDal B-PER\nMaso I-PER\ndeclined O\nto O\ncomment O\non O\nthe O\nalleged O\nfifth O\nmurder O\n, O\nsaying O\nonly O\nthat O\n\" O\nthe O\ninterrogations O\nare O\nnot O\nover O\nyet O\n\" O\nwith O\ninvestigators O\n. O\n\nIt O\nsaid O\ninvestigators O\nbelieved O\nStevanin B-PER\nhad O\nsuffocated O\nthem O\nby O\nputting O\nplastic O\nbags O\non O\ntheir O\nheads O\n. O\n\nStevanin B-PER\nwas O\nfirst O\nsentenced O\nfor O\nassault O\nbut O\ninvestigators O\nbegan O\ndigging O\nin O\nthe O\ngarden O\nof O\nhis O\nvilla O\nafter O\nthe O\nfirst O\nbody O\nwas O\nfound O\nby O\na O\npasser-by O\n. O\n\n-DOCSTART- O\n\nBelgium B-LOC\nasks O\nhow O\npaedophile O\nsuspect O\neluded O\npolice O\n. O\n\nJeremy B-PER\nLovell I-PER\n\nBRUSSELS B-LOC\n1996-08-24 O\n\nBelgian B-MISC\npolice O\nsearched O\ntwo O\nmore O\nhouses O\non O\nSaturday O\nfor O\nbodies O\nin O\na O\nchild-sex O\nscandal O\nof O\nmurder O\n, O\nkidnapping O\nand O\npornography O\nthat O\nhas O\nsent O\na O\nshockwave O\nof O\nrevulsion O\nthroughout O\nEurope B-LOC\n. O\n\nRecriminations O\nbuilt O\nup O\nover O\nhow O\nthe O\nscandal O\n's O\ncentral O\nfigure O\n, O\nconvicted O\nchild O\nrapist O\nMarc B-PER\nDutroux I-PER\n, O\nmanaged O\nto O\nprey O\non O\nchildren O\nunhindered O\nfor O\nso O\nlong O\n. O\n\nIn O\njust O\nover O\na O\nweek O\ntwo O\nyoung O\ngirls O\nhave O\nbeen O\nfound O\ndead O\n, O\nfrom O\nstarvation O\n, O\ntwo O\nhave O\nbeen O\nfreed O\nfrom O\na O\ndungeon-like O\nsecret O\ncompartment O\nand O\nan O\ninternational O\nhunt O\nhas O\nstarted O\nfor O\nat O\nleast O\ntwo O\nothers O\n. O\n\nOn O\nSaturday O\ninvestigators O\nwith O\ndogs O\ntrained O\nto O\nfind O\nbodies O\nsearched O\none O\nhouse O\nat O\nRansart B-LOC\nand O\none O\nat O\nMont-sur-Marchienne B-LOC\n-- O\nboth O\nsuburbs O\nof O\nthe O\nsouthern O\ncity O\nof O\nCharleroi B-LOC\n. O\n\nBoth O\nhouses O\nare O\nowned O\nby O\nDutroux B-PER\n. O\n\nBelgian B-MISC\nmedia O\nspeculated O\nthat O\nDutroux B-PER\n, O\ncharged O\nwith O\nabduction O\nand O\nillegal O\nimprisonment O\nof O\nchildren O\n, O\nmust O\nhave O\nhad O\nhigh O\nlevel O\nprotection O\nto O\nmolest O\nyoungsters O\n. O\n\nThey O\nput O\nforward O\nno O\nproof O\nto O\nsupport O\nthe O\nspeculation O\n, O\nbut O\nseized O\non O\na O\ncomment O\nby O\nchief O\nprosecutor O\nMichel B-PER\nBourlet I-PER\non O\nBelgian B-MISC\ntelevision O\non O\nFriday O\nnight O\nthat O\nhe O\nwould O\nchase O\ndown O\neveryone O\ninvolved O\nin O\nthe O\ncase O\n\" O\nif O\nI O\nam O\nallowed O\nto O\n\" O\n. O\n\nBourlet B-PER\nsaid O\nbetween O\n300 O\nand O\n400 O\npaedophile O\nporn O\nvideo O\ntapes O\nhad O\nbeen O\nseized O\n, O\nsome O\nof O\nwhich O\nfeatured O\nDutroux B-PER\n. O\n\nDutroux B-PER\nwas O\ncharged O\na O\nweek O\nago O\nafter O\npolice O\nrescued O\ntwo O\nyoung O\ngirls O\nfrom O\na O\nconcrete O\ndungeon O\nin O\nthe O\nbasement O\nof O\none O\nof O\nthe O\nsix O\nhouses O\nhe O\nowns O\nin O\nand O\naround O\nCharleroi B-LOC\n. O\n\nJust O\na O\nday O\nlater O\nthe O\nnational O\neuphoria O\nat O\nthe O\nrescue O\nturned O\nto O\ndisgust O\nas O\nDutroux B-PER\nled O\npolice O\nto O\nthe O\nbodies O\nof O\ntwo O\neight-year-old O\ngirls O\nin O\nanother O\nof O\nhis O\nhouses O\n. O\n\nJulie B-PER\nLejeune I-PER\nand O\nMelissa B-PER\nRusso I-PER\n, O\nhad O\nbeen O\nkidnapped O\nin O\nJune O\nlast O\nyear O\n. O\n\nDutroux B-PER\nsaid O\nthey O\nstarved O\nto O\ndeath O\nnine O\nmonths O\nlater O\n. O\n\nHe O\nalso O\nadmitted O\nkidnapping O\ntwo O\nother O\ngirls O\n, O\nAn B-PER\nMarchal I-PER\nand O\nEefje B-PER\nLambrecks I-PER\n, O\na O\nyear O\nago O\n. O\n\nThe O\nfate O\nof O\nthe O\ngirls O\nis O\nunknown O\n, O\nbut O\nthere O\nhas O\nbeen O\nspeculation O\nthey O\nwere O\nsold O\ninto O\nprostitution O\nin O\nSlovakia B-LOC\nor O\nthe O\nCzech B-LOC\nRepublic I-LOC\nwhere O\nDutroux B-PER\nwas O\na O\nfrequent O\nvisitor O\n. O\n\nBelgian B-MISC\npolice O\nhave O\nvisited O\nBratislava B-LOC\nand O\nwill O\nvisit O\nPrague B-LOC\n. O\n\nFive O\nother O\npeople O\nhave O\nbeen O\narrested O\nincluding O\nDutroux B-PER\n's O\nsecond O\nwife O\nMichelle B-PER\nMartin I-PER\n, O\ncharged O\nas O\nan O\naccomplice O\n. O\n\nThe O\nothers O\nhave O\nbeen O\ncharged O\nwith O\nabduction O\nand O\nillegal O\nimprisonment O\nof O\nchildren O\nor O\nare O\nsuspected O\nof O\ncriminal O\nassociation O\n. O\n\nDutch B-MISC\npolice O\nare O\nalso O\nholding O\na O\n74-year O\nold O\nDutchman B-MISC\nin O\nconnection O\nwith O\nthe O\ndisappearance O\nof O\nAn B-PER\nand O\nEefje B-PER\n, O\nalthough O\na O\nspokesman O\nsaid O\nno O\ndirect O\nlink O\nhad O\nyet O\nbeen O\nestablished O\n. O\n\nAt O\nleast O\npart O\nof O\nthe O\nspeculation O\nin O\nthe O\nBelgian B-MISC\nmedia O\nof O\nhigh-level O\nprotection O\nfor O\nDutroux B-PER\nand O\nhis O\naccomplices O\nis O\nbased O\non O\nleaked O\ndocuments O\ncataloguing O\na O\nhigh O\ndegree O\nof O\npolice O\nbungling O\n, O\nincompetence O\nand O\nindifference O\n. O\n\nAmong O\nthe O\nrevelations O\nare O\nthe O\nfact O\nthat O\nthe O\ngendarmerie O\nwas O\nrunning O\na O\nsurveillance O\noperation O\ncodenamed O\n\" O\nOthello B-MISC\n\" O\nagainst O\nDutroux B-PER\nin O\n1995 O\n-- O\nwhen O\nboth O\nJulie B-PER\nand O\nMelissa B-PER\nand O\nAn B-PER\nand O\nEefje B-PER\nwere O\nkidnapped O\n. O\n\nThey O\nshow O\nthat O\nthe O\ngendarmes O\nwere O\naware O\nthat O\nDutroux B-PER\nwas O\nbuilding O\ncells O\nin O\nsome O\nof O\nhis O\nhouses O\nfor O\nholding O\nchildren O\n, O\nyet O\nthis O\ninformation O\nwas O\neither O\nnot O\npassed O\non O\nto O\nother O\npolice O\nforces O\nsearching O\nfor O\nthe O\nmissing O\ngirls O\nor O\nwas O\noverlooked O\nwhen O\nit O\nwas O\n. O\n\nThey O\nalso O\nshow O\nthat O\npolice O\ninvestigating O\na O\ntheft O\nvisited O\nDutroux B-PER\nlate O\nlast O\nyear O\nat O\nthe O\nhouse O\nwhere O\nJulie B-PER\nand O\nMelissa B-PER\nwere O\nbeing O\nheld O\nbut O\naccepted O\nhis O\nword O\nthat O\nthe O\nchildren O\n's O\ncries O\nthey O\ncould O\nhear O\ncame O\nfrom O\nneighbours O\n. O\n\nJustice B-ORG\nMinister O\nStefaan B-PER\nDe I-PER\nClerck I-PER\nhas O\nadmitted O\nthat O\nmistakes O\nwere O\nmade O\nand O\nordered O\nan O\ninquiry O\nat O\nthe O\nsame O\ntime O\nas O\nstressing O\nthere O\nwere O\nno O\nindications O\nof O\na O\ncover-up O\n. O\n\nThere O\nis O\nalso O\nwidespread O\ndisbelief O\nthat O\nno O\none O\nappeared O\nto O\nquestion O\nhow O\nDutroux B-PER\n, O\nan O\nunemployed O\nfather O\nof O\nthree O\nwith O\nno O\nvisible O\nmeans O\nof O\nsupport O\n, O\nmanaged O\nto O\nown O\nsix O\nhouses O\n. O\n\n-DOCSTART- O\n\nDeath O\ntoll O\nof O\nAlgeria B-LOC\nbomb O\nput O\nat O\nseven-newspaper O\n. O\n\nPARIS B-LOC\n1996-08-24 O\n\nAn O\nAlgerian B-MISC\nnewspaper O\non O\nSaturday O\nput O\nat O\nseven O\n-- O\ntwo O\nwomen O\nand O\nfive O\nchildren O\n-- O\nthe O\ndeath O\ntoll O\nof O\na O\nbomb O\nblast O\nin O\na O\nmarket O\nwest O\nof O\nAlgiers B-LOC\non O\nFriday O\n. O\n\nAlgerian B-MISC\nsecurity O\nforces O\nsaid O\non O\nFriday O\nthree O\nwomen O\nand O\ntwo O\nchildren O\nwere O\nkilled O\nand O\nfive O\npeople O\nwounded O\nwhen O\na O\nhome-made O\nbomb O\nexploded O\nat O\na O\nmarket O\nin O\nthe O\ncoastal O\ntown O\nof O\nBou B-LOC\nHaroun I-LOC\n, O\n65 O\nkm O\n( O\n40 O\nmiles O\n) O\nwest O\nof O\nAlgiers B-LOC\n. O\n\nThe O\nsecurity O\nforces O\nalso O\nsaid O\na O\nman O\ncarrying O\nan O\nexplosive O\ndevice O\nalso O\ndied O\nafter O\nit O\nwent O\noff O\nprematurely O\n. O\n\nEl-Watan B-ORG\npaper O\nsaid O\nthe O\nblast O\nkilled O\nseven O\n-- O\na O\nmother O\nand O\nher O\n25-year-old O\ndaughter O\n, O\nfour O\nyoung O\nboys O\nand O\na O\nfive-year-old O\ngirl O\n. O\n\nSeveral O\npeople O\nwere O\nalso O\nwounded O\n, O\nit O\nsaid O\n. O\n\nThe O\nexplosion O\nwas O\nthe O\nlatest O\nin O\nseries O\nof O\nbomb O\nattacks O\nin O\nAlgeria B-LOC\n's O\nfour-year-old O\ncivil O\nstrife O\n. O\n\nThe O\ngovernment-appointed O\nwatchdog O\n, O\nHuman B-ORG\nRights I-ORG\nNational I-ORG\nObservatory I-ORG\n, O\nwas O\nquoted O\nthis O\nmonth O\nby O\nlocal O\nnewspapers O\nas O\nsaying O\nabout O\n1,400 O\ncivilians O\nhave O\ndied O\nin O\nbomb O\nattacks O\nblamed O\non O\nMoslem B-MISC\nrebels O\nin O\nthe O\npast O\ntwo O\nyears O\n. O\n\nAn O\nestimated O\n50,000 O\nAlgerians B-MISC\nand O\nmore O\nthan O\n110 O\nforeigners O\nhave O\nbeen O\nkilled O\nin O\nviolence O\npitting O\nMoslem B-MISC\nrebels O\nagainst O\ngovernment O\nforces O\nsince O\nearly O\n1992 O\n, O\nwhen O\nthe O\nauthorities O\ncancelled O\na O\ngeneral O\nelection O\nin O\nwhich O\nradical O\nIslamists B-MISC\nhad O\ntaken O\na O\ncommanding O\nlead O\n. O\n\n-DOCSTART- O\n\nMalta B-LOC\npolice O\nseize O\ncannabis O\namong O\nchilli O\nsauce O\n. O\n\nVALLETTA B-LOC\n1996-08-24 O\n\nPolice O\nin O\nMalta B-LOC\nsaid O\non O\nSaturday O\nthey O\nhad O\nseized O\n7.5 O\ntonnes O\nof O\ncannabis O\nconcealed O\nin O\na O\nshipment O\nof O\nchilli O\nsauce O\non O\nits O\nway O\nfrom O\nSingapore B-LOC\nto O\nRomania B-LOC\n. O\n\nPolice O\ncommissioner O\nGeorge B-PER\nGrech I-PER\nsaid O\nthe O\ncannabis O\nwas O\nfound O\non O\nFriday O\npacked O\nin O\n500 O\nboxes O\nhidden O\nbehind O\nchilli O\nsauce O\nin O\na O\ncontainer O\nthat O\narrived O\nat O\nMalta B-LOC\nFreeport I-LOC\na O\nweek O\nago O\n. O\n\nThe O\ncontainer O\nwas O\non O\nits O\nway O\nto O\nRomania B-LOC\nvia O\nthe O\nformer O\nYugoslavia B-LOC\nfrom O\nSingapore B-LOC\nand O\nwas O\nthe O\nbiggest O\ndrugs O\nhaul O\nin O\nMalta B-LOC\n, O\npolice O\nsaid O\n. O\n\nNo O\nstreet O\nvalue O\nwas O\ngiven O\nfor O\nthe O\ncannabis O\n. O\n\n-DOCSTART- O\n\nCzech B-MISC\ncoach O\nin O\nfatal O\ncrash O\nin O\nAustria B-LOC\n. O\n\nVIENNA B-LOC\n1996-08-24 O\n\nA O\nCzech B-MISC\ncoach O\ncrashed O\nand O\nburst O\ninto O\nflames O\non O\na O\nsouthern O\nAustrian B-MISC\nmotorway O\nearly O\non O\nSaturday O\n, O\nkilling O\none O\nperson O\nand O\ninjuring O\n15 O\n, O\npolice O\nsaid O\n. O\n\nAustrian B-MISC\ntelevision O\nsaid O\nthe O\ncoach O\n, O\nwhich O\nwas O\ncarrying O\n45 O\n, O\nwas O\nen O\nroute O\nfrom O\nthe O\nCzech B-LOC\nRepublic I-LOC\nto O\nItaly B-LOC\nwhen O\nthe O\naccident O\noccurred O\nnear O\nSteinberg B-LOC\n, O\n200 O\nkm O\nsouthwest O\nof O\nVienna B-LOC\n. O\n\n-DOCSTART- O\n\nMost O\nSpaniards O\nback O\ntalks O\nwith O\nBasque B-MISC\nrebels--poll O\n. O\n\nMADRID B-LOC\n1996-08-24 O\n\nMost O\nSpaniards O\nwould O\nsupport O\ngovernment O\ntalks O\nwith O\nthe O\nillegal O\nBasque B-MISC\nseparatist O\ngroup O\nETA B-ORG\nif O\nthe O\nrebels O\nrenounced O\nviolence O\npermanently O\n, O\na O\nsurvey O\npublished O\nin O\ndaily O\nEl B-ORG\nMundo I-ORG\non O\nSaturday O\nsaid O\n. O\n\nWhile O\n57 O\npercent O\nof O\nthe O\npopulation O\nsupported O\nnegotiations O\nwith O\nETA B-ORG\n( O\nBasque B-ORG\nHomeland I-ORG\nand I-ORG\nFreedom I-ORG\n) O\n, O\n30 O\npercent O\nopposed O\nit O\n, O\nthe O\nsurvey O\nby O\nthe O\nstate-controlled O\nCentre B-ORG\nfor I-ORG\nSociological I-ORG\nStudies I-ORG\n( O\nCIS B-ORG\n) O\nfound O\n. O\n\nBut O\n80 O\npercent O\nsaid O\nETA B-ORG\nhad O\nshown O\nlittle O\ninterest O\nin O\nachieving O\npeace O\nin O\nthe O\nBasque B-MISC\ncountry O\nwhen O\nit O\noffered O\na O\none-week O\ntruce O\nin O\nJuly O\nwhile O\ncontinuing O\nto O\nhold O\nprison O\nofficer O\nJose B-PER\nAntonio I-PER\nOrtega I-PER\nLara I-PER\n, O\nkidnapped O\nin O\nJanuary O\n. O\n\nThe O\nproblem O\nof O\nterrorism O\nhad O\nneither O\nworsened O\nnor O\nimproved O\nsince O\nthe O\nconservative O\nPopular B-ORG\nParty I-ORG\n( O\nPP B-ORG\n) O\ncame O\nto O\npower O\nin O\nMay O\n, O\naccording O\nto O\n56 O\npercent O\nof O\nthose O\nquestioned O\n, O\nwhile O\n22 O\npercent O\nsaid O\nit O\nhad O\nworsened O\n. O\n\nThe O\nsurvey O\nquestioned O\n2,496 O\npeople O\nbetween O\nJuly O\n17 O\nand O\n21 O\nand O\nhas O\na O\nmargin O\nof O\nerror O\nof O\nplus O\nor O\nminus O\ntwo O\npercent O\n. O\n\n-DOCSTART- O\n\nThirty O\nkilled O\nas O\nfloods O\nplunge O\nLahore B-LOC\ninto O\nchaos O\n. O\n\nISLAMABAD B-LOC\n1996-08-24 O\n\nAt O\nleast O\n30 O\npeople O\nhave O\nbeen O\nkilled O\nand O\nabout O\n100 O\ninjured O\nin O\nthe O\nflood-hit O\nPakistani B-MISC\ncity O\nof O\nLahore B-LOC\n, O\nnewspapers O\nreported O\non O\nSaturday O\n. O\n\nThey O\nsaid O\n461 O\nmm O\n( O\n18 O\ninches O\n) O\nof O\nrain O\nhad O\ndrenched O\nthe O\nPunjab B-LOC\nprovincial O\ncapital O\nin O\n36 O\nhours O\n, O\nturning O\nstreets O\ninto O\nrivers O\n, O\nknocking O\nout O\npower O\n, O\nwater O\nand O\ntelephone O\nservices O\n, O\ndisrupting O\nair O\nand O\nrail O\ntraffic O\n, O\nand O\nsweeping O\naway O\nhouses O\nand O\ncars O\n. O\n\nNewspapers O\nquoted O\nwitnesses O\nas O\nsaying O\nthey O\nhad O\nseen O\nbodies O\nfloating O\nin O\nthe O\nstreets O\n. O\n\nAmong O\nthe O\ndead O\nwere O\nfive O\nmembers O\nof O\nthe O\nreligious O\nJamaat-i-Islami B-ORG\nparty O\nwho O\ndrowned O\nwhile O\ntrying O\nto O\nremove O\nbooks O\nfrom O\na O\nbasement O\nlibrary O\n. O\n\nThey O\nsaid O\nthousands O\nof O\npeople O\nhad O\nbeen O\nmade O\nhomeless O\nafter O\na O\nbreach O\nopened O\nin O\nthe O\ncity O\ncanal O\n, O\ninundating O\nresidential O\nareas O\n. O\n\nArmy O\ntroops O\nwere O\ncalled O\nin O\nto O\nevacuate O\nresidents O\nof O\nlow-lying O\nareas O\nto O\nhigher O\nground O\n. O\n\nOfficials O\nsaid O\nthe O\nRavi B-LOC\nand O\nChenab B-LOC\nrivers O\n, O\nwhich O\nboth O\nflow O\nthrough O\nPunjab B-LOC\n, O\nwere O\nin O\nhigh O\nflood O\nand O\nemergency O\nservices O\nbacked O\nby O\ntroops O\nwere O\non O\nfull O\nalert O\n. O\n\n-DOCSTART- O\n\nInternet B-ORG\nStartup I-ORG\nfunded O\nto O\ndevelop O\nJava B-MISC\nsoftware O\n. O\n\nMOUNTAIN B-LOC\nVIEW I-LOC\n, O\nCalif. B-LOC\n1996-08-25 O\n\nA O\nsmall O\nteam O\nof O\nengineers O\nfrom O\nSun B-ORG\nMicrosystems I-ORG\nInc. I-ORG\n's O\nJavaSoft B-ORG\nunit O\nsaid O\nSunday O\nthey O\nhave O\nformed O\na O\nnew O\ncompany O\n, O\ndubbed O\nInternet B-ORG\nStartup I-ORG\n, O\nto O\nbuild O\nJava B-MISC\ninfrastructure O\nsoftware O\n. O\n\nThe O\nfledgling O\ncompany O\n, O\nestablished O\nin O\na O\nground-floor O\noffice O\nhere O\nover O\nthe O\nlast O\ntwo O\nweeks O\n, O\nhas O\nreceived O\nventure O\nfinancing O\nfrom O\nBessemer B-ORG\nVenture I-ORG\nPartners I-ORG\nof O\nMenlo B-LOC\nPark I-LOC\n, O\nCalif B-LOC\n.. O\n\nDavid B-PER\nCowan I-PER\n, O\nInternet B-ORG\nStartup I-ORG\nfounder O\nand O\nacting O\nchief O\nexecutive O\n, O\nis O\na O\ngeneral O\npartner O\nof O\nBessemer B-ORG\n. O\n\nThe O\nstartup O\ncompany O\n's O\nacting O\nchairman O\nis O\nJim B-PER\nBidzos I-PER\n, O\nthe O\npresident O\nof O\nRSA B-ORG\nData I-ORG\nSecurity I-ORG\n, O\na O\nunit O\nof O\nSecurity B-ORG\nDynamics I-ORG\nTechnologies I-ORG\nInc. I-ORG\nas O\nwell O\nas O\nchairman O\nof O\nVeriSign B-ORG\n. O\n\nInternet B-ORG\nStartup I-ORG\n, O\nwhich O\nopened O\nits O\ndoors O\nwith O\nabout O\nhalf O\na O\ndozen O\ninitial O\nemployees O\n, O\ncombines O\nexperience O\nat O\nJavaSoft B-ORG\n, O\nApple B-ORG\nComputer I-ORG\nInc. I-ORG\n, O\nand O\nOracle B-ORG\nSystems I-ORG\n. O\n\n\" O\nJava B-MISC\nportends O\ndramatic O\nchanges O\nin O\nthe O\nway O\nwe O\nuse O\nthe O\nInternet B-MISC\n, O\n\" O\nsaid O\nHong B-PER\nBui I-PER\n, O\nvice O\npresident O\nof O\nengineering O\nof O\nthe O\nnew O\ncompany O\nafter O\nserving O\nas O\na O\nsenior O\nengineer O\nat O\nJavaSoft B-ORG\n. O\n\nJava B-MISC\nis O\na O\ncomputer O\nprogramming O\nlanguage O\nintroduced O\nby O\nSun B-ORG\nMicrosystems I-ORG\nin O\nmid-1995 O\nwhich O\nhas O\nimmediately O\ncaptured O\nthe O\nattention O\nof O\nthe O\nindustry O\nfor O\nits O\nability O\nto O\noperate O\nacross O\nvirtually O\nall O\ncomputer O\nsystem O\nin O\na O\nrelatively O\nsecure O\nmanner O\n. O\n\nJust O\nlast O\nweek O\n, O\nSun B-ORG\nMicrosystems I-ORG\nand O\nthe O\nSilicon B-LOC\nValley I-LOC\nventure O\ncapital O\ngiant O\nKleiner B-ORG\nPerkins I-ORG\nCaufield I-ORG\n& I-ORG\nByers I-ORG\nsaid O\nthey O\nhad O\ncompleted O\nfinancing O\nof O\na O\n$ O\n100 O\nmillion O\nfund O\nmanaged O\nby O\nKleiner B-ORG\nPerkins I-ORG\nto O\nfund O\nstartups O\ndeveloping O\nJava B-MISC\ntechnologies O\n. O\n\nJava B-MISC\nhas O\nbeen O\nlicensed O\nby O\nnearly O\n50 O\norganisations O\n, O\nranging O\nfrom O\nMicrosoft B-ORG\nCorp. I-ORG\nand O\nInternational B-ORG\nBusiness I-ORG\nMachines I-ORG\nCorp. I-ORG\nto O\nthe O\nTaiwan B-LOC\ngovernment O\n. O\n\nPrasad B-PER\nWagle I-PER\n, O\nanother O\nformer O\nsenior O\nJavaSoft B-ORG\nengineer O\nwho O\nis O\namong O\nthe O\nfounding O\nengineers O\nat O\nInternet B-ORG\nStartup I-ORG\n, O\nsaid O\nthe O\nnew O\ncompany O\naims O\nto O\nbuild O\nsoftware O\ninfrastructure O\nusing O\nJava B-MISC\nto O\nmake O\nnetworked O\napplications O\nubiquitious O\n. O\n\nOne O\nfeature O\nof O\nthe O\nJava B-MISC\nlanguage O\nis O\nthat O\nsmall O\nsoftware O\nprogrammes O\n, O\nknown O\nas O\n\" O\napplets O\n\" O\nbecause O\nthey O\nare O\nsmall O\napplications O\n, O\ncan O\nbe O\ndownloaded O\nfrom O\nthe O\nserver O\ncomputers O\nat O\nthe O\ncentre O\nof O\nnetworks O\nonto O\nindividual O\ncomputers O\nfor O\nuse O\n. O\n\nIn O\nthis O\nmodel O\n, O\nindividual O\ncomputer O\nusers O\ncan O\nalways O\ngain O\naccess O\nto O\nthe O\nlatest O\nprogrammes O\nand O\ndo O\nnot O\nneed O\nto O\nstore O\nmore O\nsoftware O\nthan O\nthey O\nare O\ncurrently O\nusing O\non O\ntheir O\ncomputers O\nat O\nany O\none O\ntime O\n, O\nalso O\nsaving O\ncosts O\nof O\nmemory O\nand O\nstorage O\n. O\n\nChris B-PER\nZuleeg I-PER\n, O\na O\nveteran O\nof O\nApple B-ORG\nand O\na O\nformer O\nJavaSoft B-ORG\nmarketing O\nmanager O\n, O\nis O\nvice O\npresident O\nof O\nmarketing O\nat O\nInternet B-ORG\nStartup I-ORG\n, O\nwhose O\nWeb O\nsite O\nis O\nwww.internetstartup.com O\n. O\n\nBessemer B-ORG\nhas O\nfunded O\nnumerous O\nInternet B-MISC\npioneers O\n, O\nincluding O\nPSI B-ORG\nNet I-ORG\n, O\nVeriSign B-ORG\nand O\nIndividual B-ORG\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nMICKELSON B-PER\nWINS O\nFOURTH O\nTITLE O\nOF O\nYEAR O\nIN O\nAKRON B-LOC\n. O\n\nAKRON B-LOC\n, O\nOhio B-LOC\n1996-08-25 O\n\nPhil B-PER\nMickelson I-PER\nbirdied O\ntwo O\nof O\nthe O\nlast O\nthree O\nholes O\nto O\nwin O\nWorld B-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\nby O\nthree O\nstrokes O\nover O\nBilly B-PER\nMayfair I-PER\non O\nSunday O\n. O\n\nIt O\nwas O\nthe O\nfourth O\ntournament O\ntitle O\nthis O\nyear O\nfor O\nMickelson B-PER\n, O\nwho O\nshot O\nan O\neven-par O\n70 O\n, O\nafter O\nbeing O\ntied O\nfor O\nthe O\nlead O\nwith O\nBilly B-PER\nMayfair I-PER\nwith O\nthree O\nholes O\nto O\nplay O\n. O\n\nAlong O\nwith O\nMayfiar B-PER\nat O\n277 O\nfor O\nthe O\ntournament O\nwere O\nSteve B-PER\nStricker I-PER\n, O\nwho O\nhad O\na O\n68 O\n, O\nand O\nDuffy B-PER\nWaldorf I-PER\n, O\nwith O\na O\n66 O\n. O\n\n\" O\nIt O\nwas O\nvery O\nhard O\nto O\nsleep O\nlast O\nnight O\nbecause O\nthere O\nwas O\nso O\nmuch O\nI O\ncould O\naccomplish O\nwith O\nthis O\nwin O\n, O\n\" O\nsaid O\nMickelson B-PER\n, O\nwho O\nhad O\na O\nthree-stroke O\nlead O\nentering O\nthe O\nthird O\nround O\n. O\n\" O\n\nThis O\nwas O\na O\nwin O\nI O\nwanted O\nvery O\n, O\nvery O\nmuch O\n. O\n\" O\n\nMickelson B-PER\n's O\nvictory O\ngave O\nhim O\na O\n10 O\nyear O\nexemption O\nto O\nthe O\nPGA B-MISC\nTour I-MISC\n. O\n\nThe O\n$ O\n378,000 O\nfirst O\nplace O\ncheck O\nbrings O\nMickelson B-PER\nback O\nto O\nthe O\ntop O\nof O\nthe O\nmoney O\nlist O\nwith O\n$ O\n1,574,799 O\nwon O\nthis O\nyear O\n. O\n\n\" O\nThis O\nis O\na O\nmajor O\nchampionship O\ngolf O\ncourse O\n, O\nand O\nfor O\nme O\nto O\nperform O\nwell O\non O\nthis O\nstyle O\nof O\ncourse O\nis O\na O\nbig O\nstep O\nup O\nfor O\nme O\nin O\nmy O\ncareer O\nand O\nmy O\nperformance O\nin O\nfuture O\nmajors O\n, O\n\" O\nhe O\nsaid O\n. O\n\nMickelson B-PER\nthree-stroke O\nlead O\nwas O\ncut O\nto O\ntwo O\nwhen O\nMayfair B-PER\nbirdied O\nthe O\ncourse O\n's O\nonly O\neasy O\nhole O\n, O\nthe O\npar O\nfive O\nsecond O\nhole O\n, O\nwhile O\nMickelson B-PER\nthree-putted O\nfor O\npar O\nfrom O\n25 O\nfeet O\n. O\n\nOn O\nthe O\nback O\nnine O\nMickelson B-PER\nbegan O\ndriving O\nerratically O\n, O\nand O\npoor O\ntee O\nshots O\nresulted O\nin O\nbogeys O\non O\nthe O\n, O\neighth O\n, O\n12th O\nand O\n13th O\nholes O\n, O\nbringing O\nMickelson B-PER\nback O\nto O\nfour O\nunder O\npar O\n, O\ntied O\nwith O\nMayfair B-PER\n, O\nwho O\nhad O\nparred O\n14 O\nstraight O\nholes O\nafter O\nthe O\nbirdie O\non O\nno.2 O\n. O\n\nMickelson B-PER\nthen O\nset O\nup O\na O\ntap O\nin O\nbirdie O\non O\nthe O\n16th O\n, O\nsending O\na O\nwedge O\nshot O\nto O\n18 O\ninches O\n. O\n\nHe O\nhad O\nanother O\nbirdie O\non O\nthe O\n17th O\n, O\nwhere O\nhe O\nhis O\na O\n6-iron O\nto O\nsix O\nfeet O\n. O\n\nMayfair B-PER\nbogeyed O\nthe O\n17th O\n, O\nmissing O\na O\nfive O\nfoot O\npar O\nputt O\n, O\nand O\ndropped O\nfrom O\nsolo O\nsecond O\nplace O\nto O\na O\nthree O\nway O\ntie O\nfor O\nsecond O\n. O\n\nIt O\nwas O\nthe O\nsecond O\nsuccessive O\nyear O\nin O\nwhich O\nMayfair B-PER\nhas O\nfinished O\nrunner O\nup O\nin O\nthis O\ntournament O\n. O\n\nHe O\nlost O\nto O\nGreg B-PER\nNorman I-PER\nin O\nsudden O\ndeath O\nlast O\nyear O\n. O\n\nThe O\ndefending O\nchampion O\nwas O\nin O\ncontention O\n, O\ntwo O\nbehind O\nMickelson B-PER\nfor O\nmuch O\nof O\nthe O\nday O\n, O\nuntil O\nhe O\nbogeyed O\nthe O\n13th O\nand O\n14th O\nholes O\n. O\n\n-DOCSTART- O\n\nGOLF O\n- O\nSCORES O\nAT O\nTHE O\nWORLD B-MISC\nSERIES I-MISC\nOF I-MISC\nGOLF I-MISC\n. O\n\nAKRON B-LOC\n, O\nOhio B-LOC\n1996-08-24 O\n\nScores O\nafter O\nthe O\nfinal O\n\nround O\nof O\nthe O\n$ O\n2.1 O\nmillion O\nNEC B-MISC\nWorld I-MISC\nSeries I-MISC\nof I-MISC\nGolf I-MISC\nat O\n\nFirestone B-LOC\nC.C I-LOC\n, O\n7149 O\nyards O\n, O\npar O\n70 O\n( O\nplayers O\nU.S. B-LOC\nunless O\nnoted O\n) O\n: O\n\n274 O\nPhil B-PER\nMickelson I-PER\n70 O\n66 O\n68 O\n70 O\n\n277 O\nDuffy B-PER\nWaldorf I-PER\n70 O\n70 O\n71 O\n66 O\n, O\nSteve B-PER\nStricker I-PER\n68 O\n72 O\n69 O\n68 O\n, O\n\nBilly B-PER\nMayfair I-PER\n66 O\n71 O\n70 O\n70 O\n\n278 O\nGreg B-PER\nNorman I-PER\n( O\nAustralia B-LOC\n) O\n70 O\n68 O\n69 O\n71 O\n\n280 O\nAlexander B-PER\nCejka I-PER\n( O\nGermany B-LOC\n) O\n72 O\n71 O\n71 O\n66 O\n, O\nDavis B-PER\nLove I-PER\n70 O\n74 O\n\n67 O\n69 O\n\n281 O\nJohn B-PER\nCook I-PER\n70 O\n69 O\n71 O\n71 O\n\n282 O\nCorey B-PER\nPavin I-PER\n73 O\n70 O\n70 O\n69 O\n\n283 O\nTom B-PER\nLehman I-PER\n72 O\n69 O\n74 O\n68 O\n, O\nFred B-PER\nFunk I-PER\n72 O\n70 O\n73 O\n68 O\n, O\nMark B-PER\n\nBrooks B-PER\n69 O\n69 O\n74 O\n71 O\n, O\nNick B-PER\nFaldo I-PER\n( O\nBritain B-LOC\n) O\n70 O\n71 O\n68 O\n74 O\n\n284 O\nD.A. B-PER\nWeibring I-PER\n73 O\n69 O\n74 O\n68 O\n, O\nTim B-PER\nHerron I-PER\n70 O\n67 O\n75 O\n72 O\n, O\nMark B-PER\n\nO'Meara B-PER\n73 O\n71 O\n69 O\n71 O\n, O\nJim B-PER\nFuryk I-PER\n75 O\n69 O\n67 O\n73 O\n, O\nJustin B-PER\nLeonard I-PER\n69 O\n\n70 O\n71 O\n74 O\n\n285 O\nLoren B-PER\nRoberts I-PER\n72 O\n73 O\n71 O\n69 O\n, O\nHal B-PER\nSutton I-PER\n72 O\n69 O\n74 O\n70 O\n, O\nFred B-PER\n\nCouples B-PER\n73 O\n68 O\n72 O\n72 O\n, O\nCraig B-PER\nStadler I-PER\n73 O\n72 O\n67 O\n73 O\n\n286 O\nHidemichi B-PER\nTanaka I-PER\n( O\nJapan B-LOC\n) O\n66 O\n75 O\n75 O\n70 O\n, O\nSteve B-PER\nJones I-PER\n70 O\n69 O\n\n76 O\n71 O\n, O\nPaul B-PER\nGoydos I-PER\n66 O\n75 O\n74 O\n71 O\n, O\nErnie B-PER\nEls I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n71 O\n71 O\n\n71 O\n73 O\n\n287 O\nCostantino B-PER\nRocca I-PER\n( O\nItaly B-LOC\n) O\n74 O\n71 O\n75 O\n67 O\n, O\nClarence B-PER\nRose I-PER\n72 O\n71 O\n\n72 O\n72 O\n, O\nCraig B-PER\nParry I-PER\n( O\nAustralia B-LOC\n) O\n73 O\n75 O\n67 O\n72 O\n, O\nWillie B-PER\nWood I-PER\n75 O\n69 O\n\n69 O\n74 O\n\n288 O\nShigeki B-PER\nMaruyama I-PER\n( O\nJapan B-LOC\n) O\n75 O\n71 O\n70 O\n72 O\n, O\nAnders B-PER\nForsbrand I-PER\n( O\n\nSweden B-LOC\n) O\n70 O\n75 O\n71 O\n72 O\n\n289 O\nScott B-PER\nHoch I-PER\n71 O\n68 O\n77 O\n73 O\n\n290 O\nTom B-PER\nWatson I-PER\n79 O\n70 O\n68 O\n73 O\n\n292 O\nWayne B-PER\nWestner I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n77 O\n68 O\n73 O\n74 O\n, O\nSven B-PER\nStruver I-PER\n( O\n\nGermany B-LOC\n) O\n72 O\n72 O\n72 O\n76 O\n\n294 O\nSatoshi B-PER\nHigashi I-PER\n( O\nJapan B-LOC\n) O\n75 O\n72 O\n74 O\n73 O\n, O\nScott B-PER\nMcCarron I-PER\n76 O\n70 O\n\n74 O\n74 O\n\n295 O\nStewart B-PER\nGinn I-PER\n( O\nAustralia B-LOC\n) O\n73 O\n72 O\n77 O\n73 O\n\n298 O\nSteve B-PER\nSchneiter I-PER\n77 O\n74 O\n76 O\n71 O\n, O\nPaul B-PER\nStankowski I-PER\n74 O\n75 O\n74 O\n75 O\n, O\n\nSeiki B-PER\nOkuda I-PER\n( O\nJapan B-LOC\n) O\n81 O\n70 O\n72 O\n75 O\n\n301 O\nBrad B-PER\nBryant I-PER\n73 O\n72 O\n77 O\n79 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nHAMLET B-MISC\nCUP I-MISC\n. O\n\nCOMMACK B-LOC\n, O\nNew B-LOC\nYork I-LOC\n1996-08-24 O\n\nResults O\nat O\nthe O\nHamlet O\n\nCup B-MISC\ntennis O\ntournament O\non O\nSunday O\n( O\nprefix O\nnumber O\ndenotes O\n\nseedings O\n: O\n\nFinals O\n, O\nsingles O\n\n5 O\n- O\nAndrei B-PER\nMedvedev I-PER\n( O\nUkraine B-LOC\n) O\nbeat O\nMartin B-PER\nDamm I-PER\n( O\nCzech B-LOC\n\nRepublic B-LOC\n) O\n7-5 O\n6-3 O\n\nFinals O\n, O\ndoubles O\n\nLuke B-PER\nJensen I-PER\nand O\nMurphy B-PER\nJensen I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAlexander B-PER\nVolkov I-PER\n\n( O\nRussia B-LOC\n) O\nand O\nHandrik B-PER\nDreekmann I-PER\n( O\nGermany B-LOC\n) O\n6-3 O\n7-6 O\n( O\n7-5 O\n) O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nTOSHIBA B-MISC\nCLASSIC I-MISC\n. O\n\nCARLSBAD B-LOC\n, O\nCalifornia B-LOC\n1996-08-25 O\n\nResults O\nfrom O\nthe O\n\n$ O\n450,000 O\nToshiba B-MISC\nClassic I-MISC\ntennis O\ntournament O\non O\nSunday O\n( O\nprefix O\n\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nFinals O\n: O\n\n4 O\n- O\nKimiko B-PER\nDate I-PER\n( O\nJapan B-LOC\n) O\nbeat O\n1 O\n- O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\n( O\nSpain B-LOC\n) O\n\n3-6 O\n6-3 O\n6-0 O\n. O\n\n-DOCSTART- O\n\nRALLYING O\n- O\nLEADING O\nPOSITIONS O\nIN O\n1,000 B-MISC\nLAKES I-MISC\nRALLY I-MISC\n. O\n\nJYVASKLYA B-LOC\n, O\nFinland B-LOC\n1996-08-25 O\n\nLeading O\npositions O\non O\n\nSunday O\nafter O\n23 O\nspecial O\nstages O\nin O\nthe O\n1,000 B-MISC\nLakes I-MISC\nRally I-MISC\n, O\nsixth O\n\nround O\nof O\nthe O\nworld O\nchampionship O\n: O\n\n1. O\nTommi B-PER\nMakinen I-PER\n( O\nFinland B-LOC\n) O\nMitsubishi B-MISC\nLancer I-MISC\nthree O\nhours O\n\neight O\nminutes O\none O\nsecond O\n\n2. O\nJuha B-PER\nKankkunen I-PER\n( O\nFinland B-LOC\n) O\nToyota B-MISC\nCelica I-MISC\n12 O\nseconds O\n\nbehind O\n\n3. O\nMarcus B-PER\nGronholm I-PER\n( O\nFinland B-LOC\n) O\nToyota B-MISC\nCelica I-MISC\n2:09 O\n\n4. O\nJarmo B-PER\nKytolehto I-PER\n( O\nFinland B-LOC\n) O\nFord B-MISC\nEscort I-MISC\n2:23 O\n\n5. O\nKenneth B-PER\nEriksson I-PER\n( O\nSweden B-LOC\n) O\nSubaru B-MISC\nImpreza I-MISC\n2:39 O\n\n6. O\nCarlos B-PER\nSainz I-PER\n( O\nSpain B-LOC\n) O\nFord B-MISC\nEscort I-MISC\n3:03 O\n\n-DOCSTART- O\n\nMOTOCROSS O\n- O\nSWEDISH B-MISC\n500CC O\nGRAND B-MISC\nPRIX I-MISC\nRESULTS O\n. O\n\nLANDSKRONA B-LOC\n, O\nSweden B-LOC\n1996-08-25 O\n\nLeading O\nresults O\nin O\nthe O\n\nSwedish B-MISC\n500cc O\nmotocross O\nGrand B-MISC\nPrix I-MISC\non O\nSunday O\n: O\n\nFirst O\nrace O\n\n1. O\nJoel B-PER\nSmets I-PER\n( O\nBelgium B-LOC\n) O\nHusaberg B-ORG\n\n2. O\nPeter B-PER\nJohansson I-PER\n( O\nSweden B-LOC\n) O\nHusqvarna B-ORG\n\n3. O\nGert B-PER\nJan I-PER\nVan I-PER\nDoorn I-PER\n( O\nNetherlands B-LOC\n) O\nHonda B-ORG\n\n4. O\nJacky B-PER\nMartens I-PER\n( O\nBelgium B-LOC\n) O\nHusqvarna B-ORG\n\n5. O\nPeter B-PER\nDirkx I-PER\n( O\nBelgium B-LOC\n) O\nKTM B-ORG\n\n6. O\nDanny B-PER\nTheybers I-PER\n( O\nBelgium B-LOC\n) O\nHonda B-ORG\n\nSecond O\nrace O\n\n1. O\nShayne B-PER\nKing I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\nKTM B-ORG\n\n2. O\nMartens B-PER\n\n3. O\nTheybers B-PER\n\n4. O\nJohan B-PER\nBoonen I-PER\n( O\nBelgium B-LOC\n) O\nHusqvarna B-ORG\n\n5. O\nDietmar B-PER\nLalcher I-PER\n( O\nGermany B-LOC\n) O\nHonda B-ORG\n\n6. O\nClaus B-PER\nManne I-PER\nNielsen I-PER\n( O\nDenmark B-LOC\n) O\nKTM B-ORG\n\nOverall O\non O\nday O\n: O\n\n1. O\nMartens B-PER\n30 O\npoints O\n\n2. O\nShayne B-PER\nKing I-PER\n28 O\n\n3. O\nSmets B-PER\n27 O\n\n4. O\nTheybers B-PER\n25 O\n\n5. O\nVan B-PER\nDoorn I-PER\n24 O\n\n6. O\nJohansson B-PER\n17 O\n\nWorld O\nchampionship O\nstandings O\n( O\nafter O\n11 O\nof O\n12 O\nrounds O\n) O\n: O\n\n1. O\nShayne B-PER\nKing I-PER\n323 O\npoints O\n\n2. O\nSmets B-PER\n290 O\n\n3. O\nJohansson B-PER\n236 O\n\n4. O\nLacher B-PER\n219 O\n\n5. O\nDarryll B-PER\nKing I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\nHonda B-ORG\n178 O\n\n6. O\nVan B-PER\nDoorn I-PER\n176 O\n\n-DOCSTART- O\n\nMOTOCROSS O\n- O\nGERMAN B-MISC\n125CC O\nGRAND B-MISC\nPRIX I-MISC\nRESULTS O\n. O\n\nHOLZGERLINGEN B-LOC\n, O\nGermany B-LOC\n1996-08-25 O\n\nLeading O\nresults O\nin O\n\nthe O\nGerman B-MISC\n125cc O\nmotocross O\nGrand B-MISC\nPrix I-MISC\non O\nSunday O\n: O\n\nFirst O\nrace O\n\n1. O\nSebastien B-PER\nTortelli I-PER\n( O\nFrance B-LOC\n) O\nKawasaki B-ORG\n\n2. O\nBob B-PER\nMoore I-PER\n( O\nU.S. B-LOC\n) O\nYamaha B-ORG\n\n3. O\nLuigi B-PER\nSeguy I-PER\n( O\nFrance B-LOC\n) O\nTM B-ORG\n\n4. O\nAndi B-PER\nKanstinger I-PER\n( O\nGermany B-LOC\n) O\nHonda B-ORG\n\n5. O\nNicolas B-PER\nCharlier I-PER\n( O\nFrance B-LOC\n) O\nKawasaki B-ORG\n\n6. O\nErik B-PER\nCamerlengo I-PER\n( O\nItaly B-LOC\n) O\nYamaha B-ORG\n\nSecond O\nrace O\n\n1. O\nTortelli B-PER\n\n2. O\nMoore B-PER\n\n3. O\nAlex B-PER\nBelometti I-PER\n( O\nItaly B-LOC\n) O\nHonda B-ORG\n\n4. O\nFrederic B-PER\nVialle I-PER\n( O\nFrance B-LOC\n) O\nYamaha B-ORG\n\n5. O\nCollin B-PER\nDugmore I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nHonda B-ORG\n\n6. O\nCamerlengo B-PER\n\nOverall O\non O\nday O\n: O\n\n1. O\nTortelli B-PER\n40 O\npoints O\n\n2. O\nMoore B-PER\n34 O\n\n3. O\nSeguy B-PER\n24 O\n\n4. O\nVialle B-PER\n22 O\n\n5. O\nCamerlengo B-PER\n20 O\n\n6. O\nBelometti B-PER\n19 O\n\nFinal O\nworld O\nchampionship O\nstandings O\n: O\n\n1. O\nTortelli B-PER\n432 O\npoints O\n\n2. O\nPaul B-PER\nMalin I-PER\n( O\nBritain B-LOC\n) O\nYamaha B-ORG\n317 O\n\n3. O\nVialle B-PER\n293 O\n\n4. O\nSeguy B-PER\n192 O\n\n5. O\nMichele B-PER\nFanton I-PER\n( O\nItaly B-LOC\n) O\nKawasaki B-ORG\n160 O\n\n6. O\nDugmore B-PER\n152 O\n\n-DOCSTART- O\n\nMOTOR O\nRACING O\n- O\nLEADING O\nPLACINGS O\nIN O\nPOKKA B-MISC\n1,000 O\nKM O\nRACE O\n. O\n\nSUZUKA B-LOC\n, O\nJapan B-LOC\n1996-08-25 O\n\nLeading O\nplacings O\nin O\n\nSunday O\n's O\nPokka B-MISC\n1,000 O\nkm O\nmotor O\nrace O\n, O\nseventh O\nround O\nof O\nthe O\n\nInternational B-MISC\nEndurance I-MISC\nGT I-MISC\nchampionship I-MISC\n: O\n\n1. O\nRay B-PER\nBelim I-PER\n( O\nBritain B-LOC\n) O\n/ O\nJames B-PER\nWeaver I-PER\n( O\nBritain B-LOC\n) O\n/ O\nJ.J.Lehto O\n\n( O\nFinland B-LOC\n) O\nGulf B-MISC\nMcLaren I-MISC\nFI I-MISC\nGTR I-MISC\n171 O\nlaps O\n- O\n6 O\nhours O\n18 O\nminutes O\n\n48.637 O\nseconds O\n( O\naverage O\nspeed O\n158.82 O\nkph O\n) O\n\n2. O\nAnders B-PER\nOlofsson I-PER\n( O\nSweden B-LOC\n) O\n/ O\nLuciano B-PER\ndella I-PER\nNoce I-PER\n( O\nItaly B-LOC\n) O\nEnnea B-MISC\n\nFerrari B-MISC\nF40 I-MISC\n170 O\nlaps O\n\n3. O\nAndy B-PER\nBallace I-PER\n( O\nBritain B-LOC\n) O\n/ O\nOlivier B-PER\nGrouillard I-PER\n( O\nFrance B-LOC\n) O\nHarrods B-MISC\n\nMcLaren B-MISC\nFI I-MISC\nGTR I-MISC\n169 O\n\n4. O\nThomas B-PER\nBscher I-PER\n( O\nGermany B-LOC\n) O\n/ O\nPeter B-PER\nKox I-PER\n( O\nNetherlands B-LOC\n) O\nWest B-MISC\nMcLaren I-MISC\n\nF1 B-MISC\nGTR I-MISC\n168 O\n\n5. O\nFabien B-PER\nGiroix I-PER\n( O\nFrance B-LOC\n) O\n/ O\nJean-Denis B-PER\nDeletraz I-PER\n( O\nSwitzerland B-LOC\n) O\n\nMuller B-MISC\nMcLaren I-MISC\nF1 I-MISC\nGTR I-MISC\n167 O\n\n6. O\nLindsay B-PER\nOwen-Jones I-PER\n( O\nBritain B-LOC\n) O\n/ O\nPierre-Henri B-PER\nRaphanel I-PER\n\n( O\nFrance B-LOC\n) O\n/ O\nDavid B-PER\nBrabham I-PER\n( O\nAustralia B-LOC\n) O\nGulf B-MISC\nMcLaren I-MISC\nF I-MISC\n! I-MISC\n\nGTR B-MISC\n\n167 O\n\n7. O\nJean-Marc B-PER\nGounon I-PER\n( O\nFrance B-LOC\n) O\n/ O\nEric B-PER\nBernard I-PER\n( O\nFrance B-LOC\n) O\n/ O\nPaul B-PER\n\nBelmondo B-PER\n( O\nFrance B-LOC\n) O\nEnnea B-MISC\nFerrari I-MISC\nF40 I-MISC\n167 O\n\n8. O\nBruno B-PER\nEichmann I-PER\n( O\nGermany B-LOC\n) O\n/ O\nGerd B-PER\nRuch I-PER\n( O\nGermany B-LOC\n) O\n/ O\nRalf B-PER\nKelleners I-PER\n\n( O\nGermany B-LOC\n) O\nGT2 B-MISC\nRoock I-MISC\nPorsche I-MISC\n911 I-MISC\n164 O\n\n9. O\nStephane B-PER\nOrtelli I-PER\n( O\nFrance B-LOC\n) O\n/ O\nBob B-PER\nWollek I-PER\n( O\nFrance B-LOC\n) O\n/ O\nFranz B-PER\nKonrad I-PER\n\n( O\nAustria B-LOC\n) O\nGT2 B-MISC\nKonrad I-MISC\nPorsche I-MISC\n911 I-MISC\n164 O\n\n10. O\nCor B-PER\nEuser I-PER\n( O\nNetherlands B-LOC\n) O\n/ O\nH. B-PER\nWada I-PER\n( O\nJapan B-LOC\n) O\n/ O\nN. B-PER\nFuruya I-PER\n( O\nJapan B-LOC\n) O\nGT2 B-MISC\n\nMarcos B-MISC\nLM600 I-MISC\n162 I-MISC\n\nFastest O\nlap O\n: O\nGounon B-PER\n, O\n2 O\nminutes O\n03.684 O\nseconds O\n( O\n170.680 O\nkph O\n) O\n\nChampionship O\nstandings O\nafter O\nseven O\nrounds O\n: O\n\n1. O\nBelim B-PER\n, O\nWeaver B-PER\n156 O\npoints O\n\n2. O\nEichmann B-PER\n, O\nRuch B-PER\n116 O\n\n3. O\nBscher B-PER\n112 O\n\n4. O\nGounon B-PER\n, O\nBernard B-PER\n, O\nBelmondo B-PER\n98 O\n\n5. O\nOlofsson B-PER\n, O\ndella B-PER\nNoce I-PER\n93 O\n\n6. O\nOwen-Jones B-PER\n, O\nRaphanel B-PER\n82 O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nLEADING O\nRESULTS O\nAT O\nSHEFFIELD B-LOC\nINTERNATIONAL O\nMEETING O\n. O\n\nSHEFFIELD B-LOC\n, O\nEngland B-LOC\n1996-08-25 O\n\nLeading O\nresults O\nat O\nan O\n\ninternational O\nmeeting O\non O\nSunday O\n: O\n\nWomen O\n's O\ntriple O\njump O\n\n1. O\nSarka B-PER\nKasparkova I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n14.84 O\nmetres O\n\n2. O\nAshia B-PER\nHansen I-PER\n( O\nBritain B-LOC\n) O\n14.78 O\n\n3. O\nRodica B-PER\nMatescu I-PER\n( O\nRomania B-LOC\n) O\n14.18 O\n\nWomen O\n's O\n400 O\nmetres O\nhurdles O\n\n1. O\nDeon B-PER\nHemmings I-PER\n( O\nJamaica B-LOC\n) O\n55.13 O\nseconds O\n\n2. O\nAnne B-PER\nMarken I-PER\n( O\nBelgium B-LOC\n) O\n55.90 O\n\n3. O\nSusan B-PER\nSmith I-PER\n( O\nIreland B-LOC\n) O\n56.00 O\n\nWomen O\n's O\njavelin O\n\n1. O\nIsel B-PER\nLopez I-PER\n( O\nCuba B-LOC\n) O\n61.36 O\n\n2. O\nLouise B-PER\nMcPaul I-PER\n( O\nAustralia B-LOC\n) O\n60.66 O\n\n3. O\nSilke B-PER\nRenk I-PER\n( O\nGermany B-LOC\n) O\n60.66 O\n\nWomen O\n's O\n200 O\nmetres O\n\n1. O\nCathy B-PER\nFreeman I-PER\n( O\nAustralia B-LOC\n) O\n22.53 O\n\n2. O\nFalilat B-PER\nOgunkoya I-PER\n( O\nNigeria B-LOC\n) O\n22.58 O\n\n3. O\nJuliet B-PER\nCuthbert I-PER\n( O\nJamaica B-LOC\n) O\n22.77 O\n\n100 O\nmetres O\nhurdles O\n\n1. O\nDionne B-PER\nRose I-PER\n( O\nJamaica B-LOC\n) O\n12.83 O\n\n2. O\nMichelle B-PER\nFreeman I-PER\n( O\nJamaica B-LOC\n) O\n12.91 O\n\n3. O\nGillian B-PER\nRussell I-PER\n( O\nJamaica B-LOC\n) O\n12.95 O\n\nWomen O\n's O\n800 O\nmetres O\n\n1. O\nCharmaine B-PER\nCrooks I-PER\n( O\nCanada B-LOC\n) O\ntwo O\nminutes O\n00.42 O\nseconds O\n\n2. O\nInez B-PER\nTurner I-PER\n( O\nJamaica B-LOC\n) O\n2:01.98 O\n\n3. O\nMargaret B-PER\nCrowley I-PER\n( O\nAustralia B-LOC\n) O\n2:02.40 O\n\nMen O\n's O\npole O\nvault O\n\n1. O\nTrond B-PER\nBathel I-PER\n( O\nNorway B-LOC\n) O\n5.60 O\n\n2. O\nPat B-PER\nManson I-PER\n( O\nU.S. B-LOC\n) O\n5.60 O\n\n3. O\nTim B-PER\nLobinger I-PER\n( O\nGermany B-LOC\n) O\n5.50 O\n\nMen O\n's O\njavelin O\n\n1. O\nTom B-PER\nPukstys I-PER\n( O\nU.S. B-LOC\n) O\n86.82 O\n\n2. O\nSteve B-PER\nBackley I-PER\n( O\nBritain B-LOC\n) O\n82.20 O\n\n3. O\nNick B-PER\nNieland I-PER\n( O\nBritain B-LOC\n) O\n81.12 O\n\nWomen O\n's O\n400 O\nmetres O\n\n1. O\nMarcel B-PER\nMalone I-PER\n( O\nU.S. B-LOC\n) O\n51.50 O\n\n2. O\nKim B-PER\nGraham I-PER\n( O\nU.S. B-LOC\n) O\n52.17 O\n\n3. O\nPhylis B-PER\nSmith I-PER\n( O\nBritain B-LOC\n) O\n52.53 O\n\nMen O\n's O\n200 O\nmetres O\n\n1. O\nJeff B-PER\nWilliams I-PER\n( O\nU.S. B-LOC\n) O\n20.45 O\n\n2. O\nDoug B-PER\nTurner I-PER\n( O\nBritain B-LOC\n) O\n20.48 O\n\n3. O\nJohn B-PER\nRegis I-PER\n( O\nBritain B-LOC\n) O\n20.63 O\n\nMen O\n's O\nhigh O\njump O\n\n1. O\nCharles B-PER\nAustin I-PER\n( O\nU.S. B-LOC\n) O\n2.30 O\n\n2. O\nTim B-PER\nForsyth I-PER\n( O\nAustralia B-LOC\n) O\n2.30 O\n\n3. O\nPatrik B-PER\nSjoberg I-PER\n( O\nSweden B-LOC\n) O\n2.25 O\n\nMen O\n's O\n800 O\nmetres O\n\n1. O\nVerbjorn B-PER\nRodal I-PER\n( O\nNorway B-LOC\n) O\n1:44.93 O\n\n2. O\nBenson B-PER\nKoech I-PER\n( O\nKenya B-LOC\n) O\n1:45.96 O\n\n3. O\nVincent B-PER\nMalakwen I-PER\n( O\nKenya B-LOC\n) O\n1:46.18 O\n\nMen O\n's O\nmile O\n\n1. O\nWilliam B-PER\nTanui I-PER\n( O\nKenya B-LOC\n) O\n3:54.57 O\n\n2. O\nJohn B-PER\nMayock I-PER\n( O\nBritain B-LOC\n) O\n3:54.60 O\n\n3. O\nTony B-PER\nWhiteman I-PER\n( O\nBritain B-LOC\n) O\n3:54.87 O\n\nMen O\n's O\n400 O\nmetres O\n\n1. O\nRoger B-PER\nBlack I-PER\n( O\nBritain B-LOC\n) O\n45.05 O\n\n2. O\nMark B-PER\nRichardson I-PER\n( O\nBritain B-LOC\n) O\n45.38 O\n\n3. O\nDerek B-PER\nMills I-PER\n( O\nU.S. B-LOC\n) O\n45.48 O\n\nMen O\n's O\n100 O\nmetres O\n\n1. O\nOsmond B-PER\nEzinwa I-PER\n( O\nNigeria B-LOC\n) O\n10.06 O\n\n2. O\nIan B-PER\nMackie I-PER\n( O\nBritain B-LOC\n) O\n10.17 O\n\n3. O\nLinford B-PER\nChristie I-PER\n( O\nBritain B-LOC\n) O\n10.19 O\n\n-DOCSTART- O\n\nMOTOR O\nRACING O\n- O\nBELGIAN B-MISC\nGRAND I-MISC\nPRIX I-MISC\nRESULT O\n. O\n\nSPA-FRANCORCHAMPS B-LOC\n, O\nBelgium B-LOC\n1996-08-25 O\n\nResult O\nof O\n\nSunday O\n's O\nBelgian B-MISC\nGrand I-MISC\nPrix I-MISC\nmotor O\nrace O\n: O\n\n1. O\nMichael B-PER\nSchumacher I-PER\n( O\nGermany B-LOC\n) O\nFerrari B-ORG\n1 O\nhour O\n28 O\nminutes O\n\n15.125 O\nseconds O\n( O\naverage O\nspeed O\n208.442 O\nkph O\n) O\n\n2. O\nJacques B-PER\nVilleneuve I-PER\n( O\nCanada B-LOC\n) O\nWilliams B-ORG\n5.602 O\nseconds O\n\nbehind O\n\n3. O\nMika B-PER\nHakkinen I-PER\n( O\nFinland B-LOC\n) O\nMcLaren B-ORG\n15.710 O\n\n4. O\nJean B-PER\nAlesi I-PER\n( O\nFrance B-LOC\n) O\nBenetton B-ORG\n19.125 O\n\n5. O\nDamon B-PER\nHill I-PER\n( O\nBritain B-LOC\n) O\nWilliams B-PER\n29.179 O\n\n6. O\nGerhard B-PER\nBerger I-PER\n( O\nAustria B-LOC\n) O\nBenetton B-ORG\n29.896 O\n\n7. O\nMika B-PER\nSalo I-PER\n( O\nFinland B-LOC\n) O\nTyrrell B-ORG\n1:00.754 O\n\n8. O\nUkyo B-PER\nKatayama I-PER\n( O\nJapan B-LOC\n) O\nTyrrell B-ORG\n1:40.227 O\n\n9. O\nRicardo B-PER\nRosset I-PER\n( O\nBrazil B-LOC\n) O\nArrows B-ORG\none O\nlap O\n\n10. O\nPedro B-PER\nLamy I-PER\n( O\nPortugal B-LOC\n) O\nMinardi B-ORG\none O\nlap O\n\nDid O\nnot O\nfinish O\n: O\n\n11. O\nDavid B-PER\nCoulthard I-PER\n( O\nBritain B-LOC\n) O\nMcLaren B-ORG\n37 O\nlaps O\ncompleted O\n\n12. O\nMartin B-PER\nBrundle I-PER\n( O\nBritain B-LOC\n) O\nJordan B-ORG\n34 O\n\n13. O\nEddie B-PER\nIrvine I-PER\n( O\nBritain B-LOC\n) O\nFerrari B-ORG\n29 O\n\n14. O\nRubens B-PER\nBarrichello I-PER\n( O\nBrazil B-LOC\n) O\nJordan B-ORG\n29 O\n\n15. O\nPedro B-PER\nDiniz I-PER\n( O\nBrazil B-LOC\n) O\nLigier B-ORG\n22 O\n\n16. O\nJos B-PER\nVerstappen I-PER\n( O\nNetherland B-LOC\n) O\nArrows B-ORG\n11 O\n\nDid O\nnot O\nstart O\n( O\nfailed O\nto O\ncomplete O\none O\nlap O\n) O\n: O\n\nOlivier B-PER\nPanis I-PER\n( O\nFrance B-LOC\n) O\nLigier B-ORG\n\nJohnny B-PER\nHerbert I-PER\n( O\nBritain B-LOC\n) O\nSauber B-ORG\n\nHeinz-Harald B-PER\nFrentzen I-PER\n( O\nGermany B-LOC\n) O\nSauber B-ORG\n\nFastest O\nlap O\n: O\nBerger B-PER\n1:53.067 O\n( O\n221.857 O\nkph O\n) O\n\n-DOCSTART- O\n\nMOTOR O\nRACING O\n- O\nSCHUMACHER B-PER\nWINS O\nBELGIAN B-MISC\nGRAND I-MISC\nPRIX I-MISC\n. O\n\nSPA-FRANCOCHAMPS B-LOC\n1996-08-25 O\n\nMichael B-PER\nSchumacher I-PER\nof O\n\nGermany B-LOC\n, O\ndriving O\na O\nFerrari B-ORG\n, O\nwon O\nthe O\nBelgian B-MISC\nGrand I-MISC\nPrix I-MISC\nmotor O\n\nrace O\non O\nSunday O\n. O\n\nCanada B-LOC\n's O\nJacques B-PER\nVilleneuve I-PER\nfinished O\nsecond O\nin O\nhis O\nWilliams B-ORG\n\nand O\nMika B-PER\nHakkinen I-PER\nof O\nFinland B-LOC\nwas O\nthird O\nin O\na O\nMcLaren B-ORG\n. O\n\nFrenchman B-MISC\nJean B-PER\nAlesi I-PER\ncame O\nfourth O\nin O\nhis O\nBenetton B-ORG\nwith O\n\nBritain B-LOC\n's O\nDamon B-PER\nHill I-PER\nfifth O\nin O\na O\nWilliams B-ORG\nand O\nGerhard B-PER\nBerger I-PER\nof O\n\nAustria B-LOC\nsixth O\nin O\nthe O\nother O\nBenetton B-ORG\n. O\n\nWorld O\ndrivers O\n' O\nchampionship O\nstandings O\n( O\nafter O\n13 O\nrounds O\n) O\n: O\n\n1. O\nDamon B-PER\nHill I-PER\n( O\nBritain B-LOC\n) O\n81 O\npoints O\n\n2. O\nJacques B-PER\nVilleneuve I-PER\n( O\nCanada B-LOC\n) O\n68 O\n\n3. O\nMichael B-PER\nSchumacher I-PER\n( O\nGermany B-LOC\n) O\n39 O\n\n4. O\nJean B-PER\nAlesi I-PER\n( O\nFrance B-LOC\n) O\n38 O\n\n5. O\nMika B-PER\nHakkinen I-PER\n( O\nFinland B-LOC\n) O\n23 O\n\n6. O\nDavid B-PER\nCoulthard I-PER\n( O\nBritain B-LOC\n) O\n18 O\n\n7. O\nGerhard B-PER\nBerger I-PER\n( O\nAustria B-LOC\n) O\n17 O\n\n8. O\nOlivier B-PER\nPanis I-PER\n( O\nFrance B-LOC\n) O\n13 O\n\n9. O\nRubens B-PER\nBarrichello I-PER\n( O\nBrazil B-LOC\n) O\n12 O\n\n10. O\nEddie B-PER\nIrvine I-PER\n( O\nBritain B-LOC\n) O\n9 O\n\n11. O\nHeinz-Harald B-PER\nFrentzen I-PER\n( O\nGermany B-LOC\n) O\n6 O\n\n12. O\nMika B-PER\nSalo I-PER\n( O\nFinland B-LOC\n) O\n5 O\n\n13. O\nJohnny B-PER\nHerbert I-PER\n( O\nBritain B-LOC\n) O\n4 O\n\n14. O\nMartin B-PER\nBrundle I-PER\n( O\nBritain B-LOC\n) O\n3 O\n\n15 O\nequal O\n. O\n\nJos B-PER\nVerstappen I-PER\n( O\nNetherlands B-LOC\n) O\n1 O\n\n15 O\nequal O\n. O\n\nPedro B-PER\nDiniz I-PER\n( O\nBrazil B-LOC\n) O\n1 O\n\nConstructors O\n' O\nchampionship O\n: O\n\n1. O\nWilliams B-ORG\n149 O\npoints O\n\n2. O\nBenetton B-ORG\n55 O\n\n3. O\nFerrari B-ORG\n48 O\n\n4. O\nMcLaren B-ORG\n41 O\n\n5. O\nJordan B-ORG\n15 O\n\n6. O\nLigier B-ORG\n14 O\n\n7. O\nSauber B-ORG\n10 O\n\n8. O\nTyrrell B-ORG\n5 O\n\n9. O\nFootwork O\n1 O\n\n-DOCSTART- O\n\nRALLYING O\n- O\nLEADING O\nPOSITIONS O\nIN O\n1,000 B-MISC\nLAKES I-MISC\nRALLY I-MISC\n. O\n\nJYVASKYLA B-LOC\n, O\nFinland B-LOC\n1996-08-25 O\n\nLeading O\npositions O\n\nafter O\nsix O\nof O\nSunday O\n's O\n12 O\nspecial O\nstages O\nin O\nthe O\n1,000 B-MISC\nLakes I-MISC\n\nRally B-MISC\n, O\nsixth O\nround O\nof O\nthe O\nworld O\nchampionship O\n: O\n\n1. O\nJuha B-PER\nKankkunen I-PER\n( O\nFinland B-LOC\n) O\nToyota B-MISC\nCelica I-MISC\n2 O\nhours O\n30 O\nminutes O\n\n52 O\nseconds O\n\n3. O\nTommi B-PER\nMakinen I-PER\n( O\nFinland B-LOC\n) O\nMitsubishi B-MISC\nLancer I-MISC\n8 O\nseconds O\n\nbehind O\n\n2. O\nMarcus B-PER\nGronholm I-PER\n( O\nFinland B-LOC\n) O\nToyota B-MISC\nCelica I-MISC\n1:46 O\n\n4. O\nJarmo B-PER\nKytolehto I-PER\n( O\nFinland B-LOC\n) O\nFord B-MISC\nEscort I-MISC\n1:56 O\n\n5. O\nKenneth B-PER\nEriksson I-PER\n( O\nSweden B-LOC\n) O\nSubaru B-MISC\nImpreza I-MISC\n2:05 O\n\n6. O\nThomas B-PER\nRadstrom I-PER\n( O\nSweden B-LOC\n) O\nToyota B-MISC\nCelica I-MISC\n2:23 O\n\n-DOCSTART- O\n\nMOTORCYCLING O\n- O\nWORLD O\nSUPERBIKE O\nCHAMPIONSHIP O\nRESULTS O\n. O\n\nSUGO B-LOC\n, O\nJapan B-LOC\n1996-08-25 O\n\nLeading O\nresults O\nfrom O\nround O\n\nnine O\nof O\nthe O\nsuperbike O\nworld O\nchampionship O\non O\nSunday O\n: O\n\nFirst O\nrace O\n\n1. O\nYuuchi B-PER\nTakeda I-PER\n( O\nJapan B-LOC\n) O\nHonda B-ORG\n38 O\nminutes O\n30.054 O\nseconds O\n\n2. O\nNoriyuki B-PER\nHaga I-PER\n( O\nJapan B-LOC\n) O\nYamaha B-ORG\n38:30.140 O\n\n3. O\nWataru B-PER\nYoshikawa I-PER\n( O\nJapan B-LOC\n) O\nYamaha B-ORG\n38:32.353 O\n\n4. O\nTroy B-PER\nCorser I-PER\n( O\nAustralia B-LOC\n) O\nDucati B-ORG\n38:34.436 O\n\n5. O\nJohn B-PER\nKocinski I-PER\n( O\nU.S. B-LOC\n) O\nDucati B-ORG\n38:36.306 O\n\n6. O\nAaron B-PER\nSlight I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\nHonda B-ORG\n38:41.756 O\n\n7. O\nNorihiko B-PER\nFujiwara I-PER\n( O\nJapan B-LOC\n) O\nYamaha B-ORG\n38:43.253 O\n\n8. O\nCarl B-PER\nFogarty I-PER\n( O\nBritain B-LOC\n) O\nHonda B-ORG\n38:49.595 O\n\n9. O\nAkira B-PER\nRyo I-PER\n( O\nJapan B-LOC\n) O\nKawasaki B-ORG\n38:50.269 O\n\n10. O\nShiya B-PER\nTakeishi I-PER\n( O\nJapan B-LOC\n) O\nKawasaki B-ORG\n38:52.271 O\n\nFastest O\nlap O\n: O\nHaga B-PER\n147.159 O\nkph O\n. O\n\nSecond O\nrace O\n\n1. O\nTakuma B-PER\nAoki I-PER\n( O\nJapan B-LOC\n) O\nHonda B-ORG\n38:18.759 O\n\n2. O\nKocinski B-PER\n38:19.313 O\n\n3. O\nHaga B-PER\n38:32.040 O\n\n4. O\nSlight B-PER\n38:32.149 O\n\n5. O\nFogarty B-PER\n38:32.719 O\n\n6. O\nFujiwara B-PER\n38:33.595 O\n\n7. O\nRyo B-PER\n38:34.682 O\n\n8. O\nTakeishi B-PER\n38:34.999 O\n\n9. O\nYoshikawa B-PER\n38:35.297 O\n\n10. O\nCorser B-PER\n38:42.015 O\n\nFastest O\nlap O\n: O\nAoki B-PER\n147.786 O\nkph O\n\nWorld O\nchampionship O\nstandings O\n( O\nafter O\nnine O\nrounds O\n) O\n: O\n\n1. O\nSlight B-PER\n280 O\npoints O\n\n2. O\nCorser B-PER\n269 O\n\n3. O\nKocinski B-PER\n254 O\n\n4. O\nFogarty B-PER\n236 O\n\n5. O\nColin B-PER\nEdwards I-PER\n( O\nU.S. B-LOC\n) O\nYamaha B-ORG\n176 O\n\n6. O\nPier B-PER\nFrancesco I-PER\nChili I-PER\n( O\nItaly B-LOC\n) O\nDucati B-ORG\n175 O\n\n7. O\nSimon B-PER\nCrafar I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\nKawasaki B-ORG\n132 O\n\n8. O\nAnthony B-PER\nGobert I-PER\n( O\nAustralia B-LOC\n) O\nKawasaki B-ORG\n117 O\n\n9. O\nYoshikawa B-PER\n107 O\n\n10. O\nNeil B-PER\nHodgson I-PER\n( O\nBritain B-LOC\n) O\nDucati B-ORG\n82 O\n\nRevised O\nplacings O\nfor O\nsecond O\nrace O\nafter O\nthe O\ndisqualification O\n\nof O\nJapanese B-MISC\nrider O\nNoriyuki B-PER\nHaga I-PER\nfor O\nusing O\nan O\nillegal O\ncarburettor O\n\npart O\n: O\n\n1. O\nTakuma B-PER\nAoki I-PER\n( O\nJapan B-LOC\n) O\nHonda B-ORG\n38:18.759 O\n\n2. O\nKocinski B-PER\n38:19.313 O\n\n3. O\nSlight B-PER\n38:32.149 O\n\n4. O\nFogarty B-PER\n38:32.719 O\n\n5. O\nFujiwara B-PER\n38:33.595 O\n\n6. O\nRyo B-PER\n38:34.682 O\n\n7. O\nTakeishi B-PER\n38:34.999 O\n\n8. O\nYoshikawa B-PER\n38:35.297 O\n\n9. O\nCorser B-PER\n38:42.015 O\n\n10. O\nKeiichi B-PER\nKitigawa I-PER\n( O\nJapan B-LOC\n) O\nSuzuki B-ORG\n38:42.333 O\n\nFastest O\nlap O\n: O\nAoki B-PER\n147.786 O\nkph O\n\nRevised O\nworld O\nchampionship O\nstandings O\n( O\nafter O\nnine O\nrounds O\n) O\n: O\n\n1. O\nSlight B-PER\n283 O\npoints O\n\n2. O\nCorser B-PER\n270 O\n\n3. O\nKocinski B-PER\n254 O\n\n4. O\nFogarty B-PER\n238 O\n\n5. O\nColin B-PER\nEdwards I-PER\n( O\nU.S. B-LOC\n) O\nYamaha B-ORG\n176 O\n\n6. O\nPier B-PER\nFrancesco I-PER\nChili I-PER\n( O\nItaly B-LOC\n) O\nDucati B-ORG\n175 O\n\n7. O\nSimon B-PER\nCrafar I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\nKawasaki B-ORG\n133 O\n\n8. O\nAnthony B-PER\nGobert I-PER\n( O\nAustralia B-LOC\n) O\nKawasaki B-ORG\n117 O\n\n9. O\nYoshikawa B-PER\n108 O\n\n10. O\nNeil B-PER\nHodgson I-PER\n( O\nBritain B-LOC\n) O\nDucati B-ORG\n82 O\n\n-DOCSTART- O\n\nMOTORCYCLING O\n- O\nJAPANESE B-MISC\nWIN O\nBOTH O\nROUND O\nNINE B-PER\nSUPERBIKE O\nRACES O\n. O\n\nSUGO B-LOC\n, O\nJapan B-LOC\n1996-08-25 O\n\nTeenager O\nYuuichi B-PER\nTakeda I-PER\n, O\nracing O\nin O\nonly O\nhis O\nfirst O\nseason O\n, O\noutclassed O\nthe O\nbig O\nnames O\nto O\nwin O\nthe O\nfirst O\nrace O\nin O\nround O\nnine O\nof O\nthe O\nworld O\nsuperbike O\nchampionship O\non O\nSunday O\n. O\n\nTakeda B-PER\n, O\n18 O\n, O\nshowed O\npoise O\nfar O\nbeyond O\nhis O\nyears O\nto O\novertake O\nAustralian B-MISC\nDucati B-ORG\nrider O\nTroy B-PER\nCorser I-PER\n, O\nlast O\nyear O\n's O\nchampionship O\nrunner-up O\n, O\nwith O\nfour O\nof O\nthe O\n25 O\nlaps O\nleft O\n. O\n\nHonda B-ORG\n's O\nTakeda B-PER\nwas O\npursued O\npast O\nCorser B-PER\nby O\nthe O\nYamaha B-ORG\nduo O\nof O\nNoriyuki B-PER\nHaga I-PER\nand O\nWataru B-PER\nYoshikawa I-PER\nwith O\nHaga B-PER\nbriefly O\ntaking O\nthe O\nlead O\nin O\nthe O\nfinal O\nchicane O\non O\nthe O\nlast O\nlap O\n. O\n\nBut O\nTakeda B-PER\nfound O\none O\nmore O\nspurt O\nof O\npower O\nto O\njust O\ntake O\nthe O\nflag O\nfirst O\nwith O\nHaga B-PER\nsecond O\nand O\nYoshikawa B-PER\nthird O\n. O\n\nHaga B-PER\nhad O\nthe O\nconsolation O\nof O\nrecording O\nthe O\nfastest O\nlap O\nat O\n147.159 O\nkph O\n. O\n\nCorser B-PER\n, O\nwho O\ncrashed O\nduring O\npractice O\non O\nFriday O\n, O\nlimped O\nin O\nfourth O\n, O\nfour O\nseconds O\nbehind O\nTakeda B-PER\nwith O\nchampionship O\nleader O\nAaron B-PER\nSlight I-PER\nof O\nNew B-LOC\nZealand I-LOC\n11 O\nseconds O\nbehind O\nthe O\nwinner O\n. O\n\nIn O\nthe O\nsecond O\nrace O\n, O\nTakeda B-PER\nagain O\nchallenged O\nstrongly O\nuntil O\nthe O\nfifth O\nlap O\nfrom O\nthe O\nend O\nwhen O\nhe O\ncrashed O\nwhile O\nrunning O\nsecond O\nto O\neventual O\nrace O\nwinner O\nTakuma B-PER\nAoki I-PER\n. O\n\nAoki B-PER\n, O\nthe O\nelder O\nbrother O\nof O\nreigning O\n125cc O\nworld O\nchampion O\nHaruchika B-PER\n, O\nhad O\na O\nrace-long O\nduel O\nwith O\nJohn B-PER\nKocinski I-PER\nof O\nthe O\nUnited B-LOC\nStates I-LOC\non O\na O\nDucati B-ORG\nbefore O\ntaking O\nthe O\nchequered O\nflag O\n. O\n\nKocinski B-PER\nled O\nfor O\nthe O\nearly O\nlaps O\nbefore O\nhe O\nwas O\npassed O\nfirst O\nby O\nAoki B-PER\n, O\nwho O\nrecorded O\nthe O\nfastest O\nlap O\nof O\n147.786 O\nkph O\n, O\nand O\nthen O\nby O\nTakeda B-PER\n. O\n\nWith O\nTakeda B-PER\nout O\nof O\nthe O\nrace O\n, O\nKocinski B-PER\nregained O\nsecond O\nplace O\nbut O\nhe O\ncould O\nnot O\novertake O\nAoki B-PER\n. O\n\nHaga B-PER\nagain O\nwas O\nthe O\nunlucky O\nrider O\nfinishing O\nthird O\nahead O\nof O\nSlight B-PER\nwith O\nCorser B-PER\nin O\n10th O\nplace O\n. O\n\nBut O\nthe O\nstrong O\nshowing O\nby O\nthe O\nJapanese B-MISC\nriders O\ndid O\nnot O\nalter O\nthe O\nchampionship O\ntable O\nwith O\nSlight B-PER\nstill O\nleading O\non O\n280 O\npoints O\n, O\nfollowed O\nby O\nCorser B-PER\nwith O\n269 O\nand O\nKocinski B-PER\nwith O\n254 O\n. O\n\n-DOCSTART- O\n\nRUGBY B-MISC\nLEAGUE I-MISC\n- O\nEUROPEAN B-MISC\nSUPER I-MISC\nLEAGUE I-MISC\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nResults O\nof O\nEuropean B-MISC\nSuper I-MISC\nLeague I-MISC\n\nrugby O\nleague O\nmatches O\non O\nSunday O\n: O\n\nHalifax B-ORG\n64 O\nLeeds B-ORG\n24 O\n\nLondon B-ORG\n56 O\nCastleford B-ORG\n0 O\n\nStandings O\n: O\n\nWigan B-ORG\n22 O\n19 O\n1 O\n2 O\n902 O\n326 O\n39 O\n\nSt B-ORG\nHelens I-ORG\n21 O\n19 O\n0 O\n2 O\n884 O\n441 O\n38 O\n\nBradford B-ORG\n22 O\n17 O\n0 O\n5 O\n767 O\n409 O\n34 O\n\nLondon B-ORG\n22 O\n12 O\n1 O\n9 O\n611 O\n462 O\n25 O\n\nWarrington B-ORG\n21 O\n12 O\n0 O\n9 O\n555 O\n499 O\n24 O\n\nHalifax B-ORG\n22 O\n10 O\n1 O\n11 O\n667 O\n576 O\n21 O\n\nSheffield B-ORG\n22 O\n10 O\n0 O\n12 O\n599 O\n730 O\n20 O\n\nOldham B-ORG\n22 O\n9 O\n1 O\n12 O\n473 O\n681 O\n19 O\n\nCastleford B-ORG\n22 O\n9 O\n0 O\n13 O\n548 O\n599 O\n18 O\n\nLeeds B-ORG\n22 O\n6 O\n0 O\n16 O\n555 O\n745 O\n12 O\n\nParis B-ORG\n22 O\n3 O\n1 O\n18 O\n398 O\n795 O\n7 O\n\nWorkington B-ORG\n22 O\n2 O\n1 O\n19 O\n325 O\n1021 O\n5 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPOLLOCK B-PER\nCONCLUDES O\nWARWICKSHIRE B-ORG\nCAREER O\nWITH O\nFLOURISH O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nSouth B-MISC\nAfrican I-MISC\nfast O\nbowler O\nShaun B-PER\nPollock I-PER\nconcluded O\nhis O\nWarwickshire B-ORG\ncareer O\nwith O\na O\nflourish O\non O\nSunday O\nby O\ntaking O\nthe O\nfinal O\nthree O\nwickets O\nduring O\nthe O\ncounty O\n's O\nSunday O\nleague O\nvictory O\nover O\nWorcestershire B-ORG\n. O\n\nPollock B-PER\n, O\nwho O\nreturns O\nhome O\non O\nTuesday O\nfor O\nan O\nankle O\noperation O\n, O\ntook O\nthe O\nlast O\nthree O\nwickets O\nin O\nnine O\nballs O\nas O\nWorcestershire B-ORG\nwere O\ndismissed O\nfor O\n154 O\n. O\n\nAfter O\nan O\nhour O\n's O\ninterruption O\nfor O\nrain O\n, O\nWarwickshire B-ORG\nthen O\nreached O\nan O\nadjusted O\ntarget O\nof O\n109 O\nwith O\n13 O\nballs O\nto O\nspare O\nand O\nrecord O\ntheir O\nfifth O\nwin O\nin O\nthe O\nlast O\nsix O\ngames O\n. O\n\nWarwickshire B-ORG\nare O\ncurrently O\nin O\nfourth O\nposition O\nbehind O\nYorkshire B-ORG\n, O\nNottinghamshire B-ORG\nand O\nSurrey B-ORG\n. O\n\nYorkshire B-ORG\ncaptain O\nDavid B-PER\nByas I-PER\ncompleted O\nhis O\nthird O\nSunday O\nleague O\ncentury O\nas O\nhis O\nside O\nswept O\nclear O\nat O\nthe O\ntop O\nof O\nthe O\ntable O\n, O\nreaching O\na O\ncareer O\nbest O\n111 O\nnot O\nout O\nagainst O\nLancashire B-ORG\n. O\n\nLancashire B-ORG\n's O\ntotal O\nof O\n205 O\nfor O\neight O\nfrom O\n40 O\novers O\nlooked O\nreasonable O\nbefore O\nByas B-PER\nput O\ntheir O\nattack O\nto O\nthe O\nsword O\n, O\ncollecting O\nhis O\nruns O\nfrom O\njust O\n100 O\nballs O\nwith O\nthree O\nsixes O\nand O\nnine O\nfours O\n. O\n\nYorkshire B-ORG\neventually O\nreached O\ntheir O\ntarget O\nwith O\nonly O\nfour O\nwickets O\ndown O\nand O\n7.5 O\novers O\nto O\nspare O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nHINCHCLIFFE B-PER\nCALLED O\nINTO O\nENGLAND B-LOC\nSQUAD O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nEngland B-LOC\nmanager O\nGlenn B-PER\nHoddle I-PER\ncalled O\nup O\nuncapped O\nEverton B-ORG\ndefender O\nAndy B-PER\nHinchcliffe I-PER\non O\nSunday O\nto O\nthe O\nnational O\nsquad O\nfor O\nthe O\nopening O\nWorld B-MISC\nCup I-MISC\nqualifier O\nagainst O\nMoldova B-LOC\nnext O\nweekend O\n. O\n\nLeft-back O\nHinchcliffe B-PER\n, O\n27 O\n, O\nreplaces O\nTottenham B-ORG\n's O\nDarren B-PER\nAnderton I-PER\nwho O\nhas O\na O\nrecurring O\ngroin O\nproblem O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\n326 O\nAND O\n74-0 O\n; O\nPAKISTAN B-LOC\n521-8 O\nDECLARED O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nEngland B-LOC\nwere O\n74 O\nfor O\nno O\nwicket O\nin O\n\ntheir O\nsecond O\ninnings O\nat O\nthe O\nclose O\nof O\nthe O\nfourth O\nday O\nof O\nthe O\nthird O\n\nand O\nfinal O\ntest O\nat O\nThe B-LOC\nOval I-LOC\non O\nSunday O\n. O\n\nScores O\n: O\nEngland B-LOC\n326 O\nand O\n74-0 O\n; O\nPakistan B-LOC\n521-8 O\ndeclared O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nPREMIER O\nLEAGUE O\nSUMMARY O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nSummary O\nof O\nan O\nEnglish B-MISC\npremier O\n\nleague O\nsoccer O\nmatch O\non O\nSunday O\n: O\n\nManchester B-ORG\nUnited I-ORG\n2 O\n( O\nCruyff B-PER\n39th O\nminute O\n, O\nSolskjaer B-PER\n70th O\n) O\n\nBlackburn B-ORG\n2 O\n( O\nWarhurst B-PER\n34th O\n, O\nBohinen B-PER\n51st O\n) O\n. O\n\nHalftime O\n1-1 O\n. O\n\nAttendance O\n54,178 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nLEAGUE O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nResults O\nof O\nEnglish B-MISC\nleague O\nsoccer O\n\nmatches O\non O\nSunday O\n: O\n\nPremier O\nleague O\n\nManchester B-ORG\nUnited I-ORG\n2 O\nBlackburn B-ORG\n2 O\n\nStandings O\n( O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nSheffield B-ORG\nWednesday I-ORG\n3 O\n3 O\n0 O\n0 O\n6 O\n2 O\n9 O\n\nChelsea B-ORG\n3 O\n2 O\n1 O\n0 O\n3 O\n0 O\n7 O\n\nArsenal B-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n2 O\n6 O\n\nAston B-ORG\nVilla I-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n2 O\n6 O\n\nManchester B-ORG\nUnited I-ORG\n3 O\n1 O\n2 O\n0 O\n7 O\n4 O\n5 O\n\nSunderland B-ORG\n3 O\n1 O\n2 O\n0 O\n4 O\n1 O\n5 O\n\nLiverpool B-ORG\n3 O\n1 O\n2 O\n0 O\n5 O\n3 O\n5 O\n\nEverton B-ORG\n3 O\n1 O\n2 O\n0 O\n4 O\n2 O\n5 O\n\nTottenham B-ORG\n3 O\n1 O\n2 O\n0 O\n3 O\n1 O\n5 O\n\nNottingham B-ORG\nForest I-ORG\n3 O\n1 O\n1 O\n1 O\n5 O\n5 O\n4 O\n\nWest B-ORG\nHam I-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n4 O\n4 O\n\nLeicester B-ORG\n3 O\n1 O\n1 O\n1 O\n2 O\n3 O\n4 O\n\nNewcastle B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n4 O\n3 O\n\nMiddlesbrough B-ORG\n3 O\n0 O\n2 O\n1 O\n4 O\n5 O\n2 O\n\nDerby B-ORG\n3 O\n0 O\n2 O\n1 O\n4 O\n6 O\n2 O\n\nLeeds B-ORG\n2 O\n0 O\n1 O\n1 O\n3 O\n5 O\n1 O\n\nSouthampton B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n4 O\n1 O\n\nBlackburn B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n5 O\n1 O\n\nCoventry B-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n6 O\n1 O\n\nWimbledon B-ORG\n2 O\n0 O\n0 O\n2 O\n0 O\n5 O\n0 O\n\nDivision O\none O\n\nBarnsley B-ORG\n3 O\nHuddersfield B-ORG\n1 O\n\nStandings O\n: O\n\nBolton B-ORG\n3 O\n2 O\n1 O\n0 O\n5 O\n2 O\n7 O\n\nBarnsley B-ORG\n2 O\n2 O\n0 O\n0 O\n5 O\n2 O\n6 O\n\nWolverhampton B-ORG\n2 O\n2 O\n0 O\n0 O\n4 O\n1 O\n6 O\n\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\n2 O\n2 O\n0 O\n0 O\n4 O\n2 O\n6 O\n\nStoke B-ORG\n2 O\n2 O\n0 O\n0 O\n4 O\n2 O\n6 O\n\nBirmingham B-ORG\n2 O\n1 O\n1 O\n0 O\n5 O\n4 O\n4 O\n\nTranmere B-ORG\n2 O\n1 O\n1 O\n0 O\n4 O\n3 O\n4 O\n\nOxford B-ORG\n2 O\n1 O\n0 O\n1 O\n6 O\n2 O\n3 O\n\nIpswich B-ORG\n2 O\n1 O\n0 O\n1 O\n5 O\n3 O\n3 O\n\nBradford B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n2 O\n3 O\n\nCrystal B-ORG\nPalace I-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n2 O\n3 O\n\nHuddersfield B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n3 O\n3 O\n\nNorwich B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n3 O\n3 O\n\nReading B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n5 O\n3 O\n\nManchester B-ORG\nCity I-ORG\n3 O\n1 O\n0 O\n2 O\n2 O\n3 O\n3 O\n\nPort B-ORG\nVale I-ORG\n2 O\n0 O\n2 O\n0 O\n2 O\n2 O\n2 O\n\nSheffield B-ORG\nUnited I-ORG\n2 O\n0 O\n1 O\n1 O\n4 O\n5 O\n1 O\n\nWest B-ORG\nBromwich I-ORG\n2 O\n0 O\n1 O\n1 O\n2 O\n3 O\n1 O\n\nCharlton B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n3 O\n1 O\n\nSwindon B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n3 O\n1 O\n\nSouthend B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n6 O\n1 O\n\nGrimsby B-ORG\n2 O\n0 O\n0 O\n2 O\n3 O\n6 O\n0 O\n\nOldham B-ORG\n2 O\n0 O\n0 O\n2 O\n2 O\n5 O\n0 O\n\nPortsmouth B-ORG\n2 O\n0 O\n0 O\n2 O\n2 O\n5 O\n0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nV O\nPAKISTAN B-LOC\nFINAL O\nTEST O\nSCOREBOARD O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nScoreboard O\non O\nthe O\nfourth O\nday O\nof O\n\nthe O\nthird O\nand O\nfinal O\ntest O\nbetween O\nEngland B-LOC\nand O\nPakistan B-LOC\nat O\nThe O\n\nOval B-LOC\non O\nSunday O\n: O\n\nEngland B-LOC\nfirst O\ninnings O\n326 O\n( O\nJ. B-PER\nCrawley I-PER\n106 O\n, O\nG. B-PER\nThorpe I-PER\n54 O\n; O\nWaqar B-PER\n\nYounis B-PER\n4-95 O\n) O\n\nPakistan B-LOC\nfirst O\ninnings O\n( O\novernight O\n339-4 O\n) O\n\nSaeed B-PER\nAnwar I-PER\nc O\nCroft B-PER\nb O\nCork B-PER\n176 O\n\nAamir B-PER\nSohail I-PER\nc O\nCork B-PER\nb O\nCroft B-PER\n46 O\n\nIjaz B-PER\nAhmed I-PER\nc O\nStewart B-PER\nb O\nMullally B-PER\n61 O\n\nInzamam-ul-Haq B-PER\nc O\nHussain B-PER\nb O\nMullally B-PER\n35 O\n\nSalim B-PER\nMalik I-PER\nnot O\nout O\n100 O\n\nAsif B-PER\nMujtaba I-PER\nrun O\nout O\n13 O\n\nWasim B-PER\nAkram I-PER\nst O\nStewart B-PER\nb O\nCroft B-PER\n40 O\n\nMoin B-PER\nKhan I-PER\nb O\nSalisbury B-PER\n23 O\n\nMushtaq B-PER\nAhmed I-PER\nc O\nCrawley B-PER\nb O\nMullally B-PER\n2 O\n\nWaqar B-PER\nYounis I-PER\nnot O\nout O\n0 O\n\nExtras O\n( O\nb-4 O\nlb-5 O\nnb-16 O\n) O\n25 O\n\nTotal O\n( O\nfor O\neight O\nwickets O\n, O\ndeclared O\n) O\n521 O\n\nFall O\nof O\nwickets O\n: O\n1-106 O\n2-239 O\n3-334 O\n4-334 O\n5-365 O\n6-440 O\n7-502 O\n\n8-519 O\n\nDid O\nnot O\nbat O\n: O\nMohammad B-PER\nAkam I-PER\n\nBowling O\n: O\nLewis B-PER\n23-3-112-0 O\n, O\nMullally B-PER\n37.1-7-97-3 O\n, O\nCroft B-PER\n\n47-10-116-2 O\n, O\nCork B-PER\n23-5-71-1 O\n, O\nSalisbury B-PER\n29-3-116-1 O\n\nEngland B-LOC\nsecond O\ninnings O\n\nM. B-PER\nAtherton I-PER\nnot O\nout O\n26 O\n\nA. B-PER\nStewart I-PER\nnot O\nout O\n40 O\n\nExtras O\n( O\nnb-8 O\n) O\n8 O\n\nTotal O\n( O\nfor O\nno O\nwicket O\n) O\n74 O\n\nBowling O\n( O\nto O\ndate O\n) O\n: O\nWasim B-PER\nAkram I-PER\n7-0-35-0 O\n, O\nWaqar B-PER\nYounis I-PER\n\n7-1-24-0 O\n, O\nMushtaq B-PER\nAhmed I-PER\n7-2-11-0 O\n, O\nAamir B-PER\nSohail I-PER\n2-1-4-0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\nDECLARE O\nFIRST O\nINNINGS O\nAT O\n521-8 O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nPakistan B-LOC\ndeclared O\ntheir O\nfirst O\n\ninnings O\nat O\n521-8 O\non O\nthe O\nfourth O\nday O\nof O\nthe O\nthird O\nand O\nfinal O\ntest O\n\nagainst O\nEngland B-LOC\nat O\nThe B-LOC\nOval I-LOC\non O\nSunday O\n. O\n\nScores O\n: O\nEngland B-LOC\n326 O\n; O\nPakistan B-LOC\n521-8 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSCOTTISH B-MISC\nPREMIER O\nDIVISION O\nRESULT O\n/ O\nSTANDINGS O\n. O\n\nGLASGOW B-LOC\n1996-08-25 O\n\nResult O\nof O\na O\nScottish B-MISC\npremier O\n\ndivision O\nsoccer O\nmatch O\non O\nSunday O\n: O\n\nAberdeen B-ORG\n4 O\nHearts B-ORG\n0 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nRangers B-ORG\n3 O\n3 O\n0 O\n0 O\n7 O\n2 O\n9 O\n\nCeltic B-ORG\n3 O\n2 O\n1 O\n0 O\n9 O\n4 O\n7 O\n\nAberdeen B-ORG\n3 O\n1 O\n2 O\n0 O\n8 O\n4 O\n5 O\n\nMotherwell B-ORG\n3 O\n1 O\n2 O\n0 O\n6 O\n3 O\n5 O\n\nHibernian B-ORG\n3 O\n1 O\n1 O\n1 O\n2 O\n2 O\n4 O\n\nHearts B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n6 O\n3 O\n\nKilmarnock B-ORG\n3 O\n1 O\n0 O\n2 O\n5 O\n7 O\n3 O\n\nDundee B-ORG\nUnited I-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n3 O\n1 O\n\nDunfermline B-ORG\n2 O\n0 O\n1 O\n1 O\n2 O\n5 O\n1 O\n\nRaith B-ORG\n3 O\n0 O\n0 O\n3 O\n1 O\n8 O\n0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\n473-6 O\nAT O\nTEA O\nON O\nFOURTH O\nDAY O\nTHIRD O\nTEST O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nPakistan B-LOC\nwere O\n473-6 O\nat O\ntea O\non O\nthe O\nfourth O\nday O\nof O\nthe O\nthird O\nand O\nfinal O\ntest O\nat O\nThe B-LOC\nOval I-LOC\non O\nSunday O\nin O\nreply O\nto O\nEngland B-LOC\n's O\n326 O\n. O\n\nScores O\n: O\nEngland B-LOC\n326 O\n; O\nPakistan B-LOC\n473-6 O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nRUN-OUT O\nGIVES O\nLEWIS B-PER\nAND O\nENGLAND B-LOC\nSLIM O\nSATISFACTION O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nChris B-PER\nLewis I-PER\ndid O\nhis O\nbest O\nto O\nforget O\nhis O\ncontroversial O\nomission O\nfrom O\nthe O\nEngland B-LOC\none-day O\nsquad O\non O\nSunday O\nbut O\ncould O\nnot O\nprevent O\nPakistan B-LOC\nreasserting O\ntheir O\ndominance O\nin O\nthe O\nfinal O\ntest O\nat O\nThe B-LOC\nOval I-LOC\n. O\n\nA O\nsuper O\npiece O\nof O\nfielding O\nby O\nLewis B-PER\n, O\ndropped O\nas O\na O\ndisciplinary O\nmeasure O\nafter O\narriving O\nonly O\n35 O\nminutes O\nbefore O\nthe O\nstart O\non O\nthe O\nfourth O\nmorning O\n, O\nprovided O\nthe O\nonly O\nbright O\nspot O\nfor O\nEngland B-LOC\nas O\nthe O\ntouring O\nteam O\nbatted O\non O\nto O\nreach O\n413 O\nfor O\nfive O\nat O\nthe O\ninterval O\n, O\na O\nlead O\nof O\n87 O\n. O\n\nThe O\nsolitary O\nwicket O\nto O\nfall O\nwas O\nAsif B-PER\nMujtaba I-PER\n, O\nrun O\nout O\nfor O\n13 O\nattempting O\na O\nsecond O\nrun O\nto O\nthird O\nman O\nwhere O\nLewis B-PER\nwas O\nlurking O\nwith O\na O\npoint O\nto O\nprove O\n. O\n\nThere O\nseemed O\nscant O\ndanger O\nuntil O\nthe O\nSurrey B-ORG\nplayer O\nswooped O\non O\nto O\nthe O\nball O\nand O\nreturned O\noff O\nbalance O\nto O\ncounty O\nteam O\nmate O\nAlec B-PER\nStewart I-PER\nwho O\nwhipped O\noff O\nthe O\nbails O\n. O\n\nLewis B-PER\n, O\nthough O\n, O\ncould O\nnot O\nmake O\nsimilar O\nwaves O\nwith O\nthe O\nball O\nas O\nSalim B-PER\nMalik I-PER\nand O\nWasim B-PER\nAkram I-PER\nbatted O\nthrough O\nthe O\nrest O\nof O\nthe O\nsession O\nwith O\nfew O\nalarms O\n. O\n\nWasim B-PER\nrattled O\nalong O\nto O\n30 O\nnot O\nout O\n, O\noutscoring O\nhis O\npartner O\nwho O\nwas O\nunbeaten O\non O\n24 O\nat O\nthe O\nbreak O\n, O\nalthough O\nthe O\nweather O\nwas O\nagain O\nthreatening O\nto O\nplay O\nthe O\ndominant O\nrole O\n. O\n\nRain O\narrived O\njust O\nas O\nthe O\nplayers O\nleft O\nthe O\nfield O\nfor O\nlunch O\n, O\nforcing O\nthe O\nground-staff O\ninto O\naction O\nyet O\nagain O\n. O\n\nThe O\nweather O\ndelayed O\nthe O\nresumption O\nfor O\nover O\nan O\nhour O\n, O\nthe O\numpires O\nfinally O\nannouncing O\nplay O\nwould O\nstart O\nagain O\nat O\n1445 O\nlocal O\ntime O\n( O\n1345 O\nGMT B-MISC\n) O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nNAME O\nSQUAD O\nFOR O\nONE-DAY O\nINTERNATIONALS O\n. O\n\nLONDON B-LOC\n1996-08-25 O\n\nThe O\nEngland B-LOC\ncricket O\nsquad O\nwas O\nannounced O\non O\nSunday O\nfor O\nthe O\none-day O\ninternational O\nseries O\nagainst O\nPakistan B-LOC\nstarting O\non O\nThursday O\n. O\n\nSquad O\n: O\nMichael B-PER\nAtherton I-PER\n( O\ncaptain O\n) O\n, O\nAlec B-PER\nStewart I-PER\n, O\nGraham B-PER\nThorpe I-PER\n, O\nNick B-PER\nKnight I-PER\n, O\nGraham B-PER\nLloyd I-PER\n, O\nMatthew B-PER\nMaynard I-PER\n, O\nRonnie B-PER\nIrani I-PER\n, O\nAdam B-PER\nHollioake I-PER\n, O\nRobert B-PER\nCroft I-PER\n, O\nDarren B-PER\nGough I-PER\n, O\nPeter B-PER\nMartin I-PER\n, O\nDean B-PER\nHeadley I-PER\n, O\nAlan B-PER\nMullally I-PER\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nCANADIAN B-MISC\nOPEN I-MISC\n. O\n\nTORONTO B-LOC\n1996-08-25 O\n\nResults O\nfrom O\nthe O\nCanadian B-MISC\nOpen I-MISC\n\ntennis O\ntournament O\non O\nSunday O\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nFinal O\n\n3 O\n- O\nWayne B-PER\nFerreira I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\nTodd B-PER\nWoodbridge I-PER\n\n( O\nAustralia B-LOC\n) O\n6-2 O\n6-4 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nRESULTS O\nAT O\nCANADIAN B-MISC\nOPEN I-MISC\n. O\n\nTORONTO B-LOC\n1996-08-24 O\n\nResults O\nfrom O\nthe O\nCanadian B-MISC\nOpen I-MISC\n\ntennis O\ntournament O\non O\nSaturday O\n( O\nprefix O\nnumbers O\ndenotes O\n\nseedings O\n) O\n: O\n\nSemifinals O\n\n3 O\n- O\nWayne B-PER\nFerreira I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\n7 O\n- O\nTodd B-PER\nMartin I-PER\n( O\nU.S. B-LOC\n) O\n\n4-6 O\n6-3 O\n7-5 O\n\nTodd B-PER\nWoodbridge I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\n4 O\n- O\nMarcelo B-PER\nRios I-PER\n( O\nChile B-LOC\n) O\n6-0 O\n\n6-3 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nTOGO B-LOC\nBEAT O\nCONGO B-LOC\n1-0 O\nIN O\nAFRICA B-MISC\nNATIONS I-MISC\nCUP I-MISC\nQUALIFIER O\n. O\n\nLOME B-LOC\n1996-08-25 O\n\nTogo B-LOC\nbeat O\nCongo B-LOC\n1-0 O\n( O\nhalftime O\n0-0 O\n) O\n\nin O\ntheir O\nAfrican B-MISC\nNations I-MISC\nCup I-MISC\npreliminary O\nround O\n, O\nsecond O\nleg O\n\nqualifying O\nmatch O\non O\nSunday O\n. O\n\nScorer O\n: O\nSalou B-PER\nBachirou I-PER\n( O\n53rd O\nminute O\n) O\n\nAttendance O\n: O\n18,000 O\n\nTogo B-LOC\nwin O\n1-0 O\non O\naggregate O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nETHIOPIA B-LOC\nBEAT O\nUGANDA B-LOC\nON O\nPENALTIES O\nIN O\nAFRICAN B-MISC\nNATIONS I-MISC\nCUP I-MISC\n. O\n\nADDIS B-LOC\nABABA I-LOC\n1996-08-25 O\n\nEthiopia B-LOC\nand O\nUganda B-LOC\ndrew O\n1-1 O\n\n( O\nhalftime O\n1-0 O\n) O\nin O\ntheir O\nAfrican B-MISC\nNations I-MISC\nCup I-MISC\npreliminary O\nround O\n, O\n\nsecond O\nleg O\nmatch O\non O\nSunday O\n. O\n\nAttendance O\n: O\n25,000 O\n\nAggregate O\n2-2 O\n. O\n\nEthiopia B-LOC\nwon O\n4-2 O\npenalties O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nYUGOSLAV B-MISC\nLEAGUE O\nRESULTS O\n. O\n\nBELGRADE B-LOC\n1996-08-25 O\n\nResults O\nof O\nYugoslav B-MISC\nleague O\n\nsoccer O\nmatches O\nplayed O\non O\nSunday O\n: O\n\nDivision O\nA O\n\nVojvodina B-ORG\n1 O\nPartizan B-ORG\n1 O\n\nCrvena B-ORG\nzvezda I-ORG\n3 O\nProleter B-ORG\n1 O\n\nDivision O\nB O\n\nZelesnik B-ORG\n0 O\nRudar B-ORG\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nLEADING O\nGOALSCORERS O\nIN O\nPOLISH B-MISC\nFIRST O\nDIVISION O\n. O\n\nWARSAW B-LOC\n1996-08-25 O\n\nLeading O\ngoalscorers O\nin O\nthe O\nPolish B-MISC\n\nfirst O\ndivision O\nafter O\nthe O\nweekend O\n's O\nmatches O\n: O\n\n7 O\n- O\nBogdan B-PER\nPrusek I-PER\n( O\nSokol B-ORG\nTychy I-ORG\n) O\n\n5 O\n- O\nSlawomir B-PER\nWojciechowski I-PER\n( O\nGKS B-ORG\nKatowice I-ORG\n) O\n\n4 O\n- O\nJacek B-PER\nDembinski I-PER\n( O\nWidzew B-ORG\nLodz I-ORG\n) O\n, O\nMarcin B-PER\nMieciel I-PER\n\n( O\nLegia B-ORG\nWarsaw I-ORG\n) O\n, O\nRyszard B-PER\nWieczorek I-PER\n( O\nOdra B-ORG\nWodzislaw I-ORG\n) O\n\n3 O\n- O\nJacek B-PER\nBerensztain I-PER\n( O\nGKS B-ORG\nBelchatow I-ORG\n) O\n, O\nMarek B-PER\nCitko I-PER\n( O\nWidzew B-ORG\n) O\n, O\n\nAdam B-PER\nFedoruk I-PER\n, O\nDariusz B-PER\nJackiewicz I-PER\n( O\nboth O\nAmica B-ORG\nWronki I-ORG\n) O\n, O\n\nBartlomiej B-PER\nJamroz I-PER\n( O\nHutnik B-ORG\nKrakow I-ORG\n) O\n, O\nTomasz B-PER\nMoskal I-PER\n\n( O\nSlask B-ORG\nWroclaw I-ORG\n) O\n, O\nKrzysztof B-PER\nPiskula I-PER\n( O\nLech B-ORG\nPoznan I-ORG\n) O\n, O\nMariusz B-PER\n\nSrutwa B-PER\n( O\nRuch B-ORG\nChorzow I-ORG\n) O\n, O\nEmmanuel B-PER\nTetteh I-PER\n( O\nPolonia B-ORG\nWarszawa I-ORG\n) O\n, O\n\nKrzysztof B-PER\nZagorski I-PER\n( O\nOdra B-ORG\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nROMANIAN B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nBUCHAREST B-LOC\n1996-08-25 O\n\nResults O\nof O\nfirst O\ndivision O\n\nsoccer O\nmatches O\nplayed O\nover O\nthe O\nweekend O\n: O\n\nA.S. B-ORG\nBacau I-ORG\n1 O\nCeahlaul B-ORG\nPiatra I-ORG\nNeamt I-ORG\n1 O\n\nOtelul B-ORG\nGalati I-ORG\n1 O\nF.C. B-ORG\nArges I-ORG\nDacia I-ORG\nPitesti I-ORG\n0 O\n\nF.C. B-ORG\nFarul I-ORG\nConstanta I-ORG\n3 O\nChindia B-ORG\nTirgoviste I-ORG\n1 O\n\nSportul B-ORG\nStudentesc I-ORG\n4 O\nUniversitatea B-ORG\nCraiova I-ORG\n2 O\n\nF.C. B-ORG\nPetrolul I-ORG\nPloiesti I-ORG\n4 O\nPolitehnica B-ORG\nTimisoara I-ORG\n5 O\n\nF.C. B-ORG\nBrasov I-ORG\n1 O\nF.C. B-ORG\nNational I-ORG\nBucharest I-ORG\n1 O\n\nJiul B-ORG\nPetrosani I-ORG\n1 O\nDinamo B-ORG\nBucharest I-ORG\n0 O\n\nGloria B-ORG\nBistrita I-ORG\n0 O\nUniversitatea B-ORG\nCluj I-ORG\n1 O\n\nRapid B-ORG\nBucharest I-ORG\n0 O\nSteaua B-ORG\nBucharest I-ORG\n2 O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nDinamo B-ORG\nBucharest I-ORG\n4 O\n3 O\n0 O\n1 O\n6 O\n2 O\n9 O\n\nJiul B-ORG\nPetrosani I-ORG\n4 O\n3 O\n0 O\n1 O\n6 O\n4 O\n9 O\n\nF.C. B-ORG\nFarul I-ORG\nConstanta I-ORG\n4 O\n2 O\n2 O\n0 O\n6 O\n2 O\n8 O\n\nUniversitatea B-ORG\nCluj I-ORG\n4 O\n2 O\n2 O\n0 O\n6 O\n4 O\n8 O\n\nA.S. B-ORG\nBacau I-ORG\n4 O\n2 O\n1 O\n1 O\n7 O\n3 O\n7 O\n\nPolitehnica B-ORG\nTimisoara I-ORG\n4 O\n2 O\n1 O\n1 O\n11 O\n9 O\n7 O\n\nF.C. B-ORG\nNational I-ORG\nBucharest I-ORG\n4 O\n2 O\n1 O\n1 O\n7 O\n6 O\n7 O\n\nOtelul B-ORG\nGalati I-ORG\n4 O\n2 O\n0 O\n2 O\n4 O\n3 O\n6 O\n\nF.C. B-ORG\nChindia I-ORG\nTirgoviste I-ORG\n4 O\n2 O\n0 O\n2 O\n3 O\n4 O\n6 O\n\nSteaua B-ORG\nBucharest I-ORG\n4 O\n2 O\n0 O\n2 O\n5 O\n7 O\n6 O\n\nF.C. B-ORG\nArges I-ORG\nDacia I-ORG\nPitesti I-ORG\n4 O\n1 O\n2 O\n1 O\n4 O\n2 O\n5 O\n\nUniversitatea B-ORG\nCraiova I-ORG\n4 O\n1 O\n1 O\n2 O\n8 O\n6 O\n4 O\n\nSportul B-ORG\nStudentesc I-ORG\n4 O\n1 O\n1 O\n2 O\n7 O\n9 O\n4 O\n\nCeahlaul B-ORG\nPiatra I-ORG\nNeamt I-ORG\n4 O\n1 O\n1 O\n2 O\n2 O\n4 O\n4 O\n\nF.C. B-ORG\nBrasov I-ORG\n4 O\n1 O\n1 O\n2 O\n6 O\n10 O\n4 O\n\nGloria B-ORG\nBistrita I-ORG\n4 O\n1 O\n0 O\n3 O\n3 O\n9 O\n3 O\n\nF.C. B-ORG\nPetrolul I-ORG\nPloiesti I-ORG\n4 O\n0 O\n2 O\n2 O\n5 O\n7 O\n2 O\n\nRapid B-ORG\nBucharest I-ORG\n4 O\n0 O\n1 O\n3 O\n4 O\n9 O\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPOLISH B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nWARSAW B-LOC\n1996-08-25 O\n\nResults O\nof O\nPolish B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatches O\nplayed O\nover O\nthe O\nweekend O\n: O\n\nAmica B-ORG\nWronki I-ORG\n3 O\nHutnik B-ORG\nKrakow I-ORG\n0 O\n\nSokol B-ORG\nTychy I-ORG\n5 O\nLech B-ORG\nPoznan I-ORG\n3 O\n\nRakow B-ORG\nCzestochowa I-ORG\n1 O\nStomil B-ORG\nOlsztyn I-ORG\n4 O\n\nWisla B-ORG\nKrakow I-ORG\n1 O\nGornik B-ORG\nZabrze I-ORG\n0 O\n\nSlask B-ORG\nWroclaw I-ORG\n3 O\nOdra B-ORG\nWodzislaw I-ORG\n1 O\n\nGKS B-ORG\nKatowice I-ORG\n1 O\nPolonia B-ORG\nWarsaw I-ORG\n0 O\n\nZaglebie B-ORG\nLubin I-ORG\n2 O\nLKS B-ORG\nLodz I-ORG\n1 O\n\nLegia B-ORG\nWarsaw I-ORG\n3 O\nGKS B-ORG\nBelchatow I-ORG\n2 O\n\nWidzew B-ORG\nLodz I-ORG\n3 O\nRuch B-ORG\nChorzow I-ORG\n0 O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nAmica B-ORG\nWronki I-ORG\n7 O\n5 O\n1 O\n1 O\n13 O\n8 O\n16 O\n\nLegia B-ORG\nWarsaw I-ORG\n7 O\n5 O\n1 O\n1 O\n13 O\n7 O\n16 O\n\nLech B-ORG\nPoznan I-ORG\n7 O\n5 O\n0 O\n2 O\n12 O\n9 O\n15 O\n\nWidzew B-ORG\nLodz I-ORG\n7 O\n4 O\n2 O\n1 O\n13 O\n3 O\n14 O\n\nGKS B-ORG\nKatowice I-ORG\n7 O\n4 O\n2 O\n1 O\n12 O\n9 O\n14 O\n\nSokol B-ORG\nTychy I-ORG\n7 O\n4 O\n0 O\n3 O\n14 O\n15 O\n12 O\n\nOdra B-ORG\nWodzislaw I-ORG\n7 O\n3 O\n1 O\n3 O\n13 O\n10 O\n10 O\n\nSlask B-ORG\nWroclaw I-ORG\n7 O\n3 O\n1 O\n3 O\n8 O\n7 O\n10 O\n\nPolonia B-ORG\nWarsaw I-ORG\n7 O\n3 O\n1 O\n3 O\n7 O\n9 O\n10 O\n\nGKS B-ORG\nBelchatow I-ORG\n7 O\n3 O\n0 O\n4 O\n9 O\n9 O\n9 O\n\nStomil B-ORG\nOlsztyn I-ORG\n7 O\n2 O\n3 O\n2 O\n9 O\n9 O\n9 O\n\nWisla B-ORG\nKrakow I-ORG\n7 O\n2 O\n3 O\n2 O\n3 O\n4 O\n9 O\n\nHutnik B-ORG\nKrakow I-ORG\n7 O\n3 O\n0 O\n4 O\n8 O\n10 O\n9 O\n\nRakow B-ORG\nCzestochowa I-ORG\n7 O\n2 O\n1 O\n4 O\n6 O\n10 O\n7 O\n\nZaglebie B-ORG\nLubin I-ORG\n7 O\n1 O\n3 O\n3 O\n10 O\n12 O\n6 O\n\nRuch B-ORG\nChorzow I-ORG\n7 O\n1 O\n2 O\n4 O\n7 O\n13 O\n5 O\n\nGornik B-ORG\nZabrze I-ORG\n7 O\n1 O\n1 O\n5 O\n6 O\n10 O\n4 O\n\nLKS B-ORG\nLodz I-ORG\n7 O\n0 O\n2 O\n5 O\n4 O\n13 O\n2 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nRUSSIAN B-MISC\nPREMIER O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nMOSCOW B-LOC\n1996-08-25 O\n\nResults O\nof O\nRussian B-MISC\npremier O\nleague O\n\nmatches O\nplayed O\non O\nSaturday O\n: O\n\nAlaniya B-ORG\nVladikavkaz I-ORG\n3 O\nZhemchuzhina B-ORG\nSochi I-ORG\n1 O\n\nBaltika B-ORG\nKaliningrad I-ORG\n2 O\nZenit B-ORG\nSt I-ORG\nPetersburg I-ORG\n0 O\n\nChernomorets B-ORG\nNovorossiisk I-ORG\n2 O\nRostselmash B-ORG\nRostov I-ORG\n1 O\n\nLokomotiv B-ORG\nMoscow I-ORG\n2 O\nTorpedo B-ORG\nMoscow I-ORG\n1 O\n\nRotor B-ORG\nVolgograd I-ORG\n0 O\nDynamo B-ORG\nMoscow I-ORG\n1 O\n\nCSKA B-ORG\nMoscow I-ORG\n4 O\nKamaz B-ORG\nNaberezhnye I-ORG\nChelny I-ORG\n2 O\n\nLada B-ORG\nTogliatti I-ORG\n1 O\nSpartak B-ORG\nMoscow I-ORG\n1 O\n\nTekstilshik B-ORG\nKamyshin I-ORG\n2 O\nKrylya B-ORG\nSovetov I-ORG\nSamara I-ORG\n1 O\n\nLokomotiv B-ORG\nNizhny I-ORG\nNovgorod I-ORG\n2 O\nUralmash B-ORG\nYekaterinburg I-ORG\n2 O\n\nStandings O\n( O\ntabulate O\nunder O\ngames O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\n\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n. O\n\nNote O\n- O\nif O\nmore O\nthan O\none O\nteam O\nhas O\nthe O\nsame O\nnumber O\nof O\npoints O\n, O\n\nprecedence O\nis O\ngiven O\nto O\nthe O\none O\nwith O\nmost O\nwins O\n. O\n\nIf O\nmore O\nthan O\none O\n\nteam O\nhas O\nthe O\nsame O\nnumber O\nof O\nwins O\nand O\npoints O\n, O\nprecedence O\ngoes O\nto O\n\nthe O\nside O\nwith O\nthe O\nmost O\nsuccessful O\nrecord O\nagainst O\nthe O\nothers O\n) O\n. O\n\nAlaniya B-ORG\nVladikavkaz I-ORG\n24 O\n16 O\n5 O\n3 O\n48 O\n25 O\n53 O\n\nDynamo B-ORG\nMoscow I-ORG\n25 O\n15 O\n7 O\n3 O\n43 O\n21 O\n52 O\n\nRotor B-ORG\nVolgograd I-ORG\n23 O\n15 O\n5 O\n3 O\n42 O\n17 O\n50 O\n\nSpartak B-ORG\nMoscow I-ORG\n25 O\n14 O\n7 O\n4 O\n48 O\n24 O\n49 O\n\nCSKA B-ORG\nMoscow I-ORG\n25 O\n13 O\n6 O\n6 O\n40 O\n27 O\n45 O\n\nLokomotiv B-ORG\nNizhny I-ORG\nNovgorod I-ORG\n25 O\n11 O\n4 O\n10 O\n27 O\n35 O\n37 O\n\nLokomotiv B-ORG\nMoscow I-ORG\n25 O\n9 O\n9 O\n7 O\n30 O\n24 O\n36 O\n\nBaltika B-ORG\nKaliningrad I-ORG\n25 O\n8 O\n10 O\n7 O\n29 O\n26 O\n34 O\n\nTorpedo B-ORG\nMoscow I-ORG\n25 O\n8 O\n9 O\n8 O\n31 O\n33 O\n33 O\n\nZenit B-ORG\nSt I-ORG\nPetersburg I-ORG\n24 O\n9 O\n4 O\n11 O\n24 O\n26 O\n31 O\n\nKrylya B-ORG\nSovetov I-ORG\nSamara I-ORG\n25 O\n8 O\n7 O\n10 O\n19 O\n29 O\n31 O\n\nZhemchuzhina B-ORG\nSochi I-ORG\n25 O\n8 O\n4 O\n13 O\n26 O\n38 O\n28 O\n\nRostselmash B-ORG\nRostov I-ORG\n24 O\n7 O\n7 O\n10 O\n42 O\n38 O\n28 O\n\nChernomorets B-ORG\nNovorossiisk I-ORG\n25 O\n7 O\n5 O\n13 O\n25 O\n38 O\n26 O\n\nKamaz B-ORG\nNaberezhnye I-ORG\nChelny I-ORG\n24 O\n5 O\n4 O\n15 O\n25 O\n42 O\n19 O\n\nLada B-ORG\nTogliatti I-ORG\n24 O\n4 O\n6 O\n14 O\n15 O\n37 O\n18 O\n\nTekstilshchik B-ORG\nKamyshin I-ORG\n25 O\n3 O\n9 O\n13 O\n15 O\n30 O\n18 O\n\nUralmash B-ORG\nYekaterinburg I-ORG\n24 O\n3 O\n8 O\n13 O\n24 O\n43 O\n16 O\n\n-DOCSTART- O\n\nAUSTRALIAN B-MISC\nRULES-AFL I-MISC\nRESULTS O\nAND O\nSTANDINGS O\n. O\n\nMELBOURNE B-LOC\n1996-08-25 O\n\nResults O\nof O\nAustralian B-MISC\nRules I-MISC\n\nmatches O\nplayed O\nat O\nthe O\nweekend O\n. O\n\nPlayed O\nSunday O\n: O\n\nAdelaide B-ORG\n14.12 O\n( O\n96 O\n) O\nCollingwood B-ORG\n24 O\n. O\n\n9 O\n( O\n153 O\n) O\n\nWest B-ORG\nCoast I-ORG\n24 O\n. O\n\n7 O\n( O\n151 O\n) O\nMelbourne B-ORG\n11.12 O\n( O\n78 O\n) O\n\nRichmond B-ORG\n28.19 O\n( O\n187 O\n) O\nFitzroy B-ORG\n5 O\n. O\n\n6 O\n( O\n36 O\n) O\n\nPlayed O\nSaturday O\n: O\n\nCarlton B-ORG\n13.18 O\n( O\n96 O\n) O\nFootscray B-ORG\n9.12 O\n( O\n66 O\n) O\n\nEssendon B-ORG\n14.16 O\n( O\n100 O\n) O\nSydney B-ORG\n12.10 O\n( O\n82 O\n) O\n\nSt B-ORG\nKilda I-ORG\n9 O\n. O\n\n9 O\n( O\n63 O\n) O\nHawthorn B-ORG\n12 O\n. O\n\n8 O\n( O\n80 O\n) O\n\nBrisbane B-ORG\n10.11 O\n( O\n71 O\n) O\nFremantle B-ORG\n10.10 O\n( O\n70 O\n) O\n\nPlayed O\nFriday O\n: O\n\nNorth B-ORG\nMelbourne I-ORG\n14.12 O\n( O\n96 O\n) O\nGeelong B-ORG\n16.13 O\n( O\n109 O\n) O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\npoints O\n\nfor O\n, O\nagainst O\n, O\npercentage O\n, O\ntotal O\npoints O\n) O\n: O\n\nBrisbane B-ORG\n21 O\n15 O\n1 O\n5 O\n2123 O\n1631 O\n130.2 O\n62 O\n\nSydney B-ORG\n21 O\n15 O\n1 O\n5 O\n2067 O\n1687 O\n122.5 O\n62 O\n\nWest B-ORG\nCoast I-ORG\n21 O\n15 O\n0 O\n6 O\n2151 O\n1673 O\n128.6 O\n60 O\n\nNorth B-ORG\nMelbourne I-ORG\n21 O\n15 O\n0 O\n6 O\n2385 O\n1873 O\n127.3 O\n60 O\n\nCarlton B-ORG\n21 O\n14 O\n0 O\n7 O\n2009 O\n1844 O\n108.9 O\n56 O\n\nGeelong B-ORG\n21 O\n13 O\n1 O\n7 O\n2288 O\n1940 O\n117.9 O\n54 O\n\nEssendon B-ORG\n21 O\n13 O\n1 O\n7 O\n2130 O\n1947 O\n109.4 O\n54 O\n\nRichmond B-ORG\n21 O\n11 O\n0 O\n10 O\n2173 O\n1803 O\n120.5 O\n44 O\n\nHawthorn B-ORG\n21 O\n10 O\n1 O\n10 O\n1791 O\n1820 O\n98.4 O\n42 O\n\nSt B-ORG\nKilda I-ORG\n21 O\n9 O\n0 O\n12 O\n1909 O\n1958 O\n97.5 O\n36 O\n\nCollingwood B-ORG\n21 O\n8 O\n0 O\n13 O\n2103 O\n2091 O\n100.6 O\n32 O\n\nAdelaide B-ORG\n21 O\n8 O\n0 O\n13 O\n2158 O\n2183 O\n98.9 O\n32 O\n\nMelbourne B-ORG\n21 O\n7 O\n0 O\n14 O\n1642 O\n2361 O\n69.5 O\n28 O\n\nFremantle B-ORG\n21 O\n6 O\n0 O\n15 O\n1673 O\n1912 O\n87.5 O\n24 O\n\nFootscray B-ORG\n21 O\n5 O\n1 O\n15 O\n1578 O\n2060 O\n76.6 O\n22 O\n\nFitzroy B-ORG\n21 O\n1 O\n0 O\n20 O\n1381 O\n2778 O\n49.7 O\n4 O\n\n-DOCSTART- O\n\nRUGBY B-MISC\nLEAGUE I-MISC\n- O\nAUSTRALIAN B-MISC\nRUGBY O\nLEAGUE O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nSYDNEY B-LOC\n1996-08-25 O\n\nResults O\nof O\nAustralian B-MISC\nrugby O\nleague O\nmatches O\nplayed O\nat O\nthe O\nweekend O\n. O\n\nPlayed O\nSunday O\n: O\n\nSydney B-ORG\nBulldogs I-ORG\n17 O\nSouth B-ORG\nQueensland I-ORG\n16 O\nBrisbane B-ORG\n38 O\nGold B-ORG\nCoast I-ORG\n10 O\n\nNorth B-ORG\nSydney I-ORG\n46 O\nSouth B-ORG\nSydney I-ORG\n4 O\n\nIllawarra B-ORG\n42 O\nPenrith B-ORG\n2 O\n\nSt B-ORG\nGeorge I-ORG\n20 O\nNorth B-ORG\nQueensland I-ORG\n24 O\n\nManly B-ORG\n42 O\nWestern B-ORG\nSuburbs I-ORG\n12 O\n\nPlayed O\nSaturday O\n: O\n\nParramatta B-ORG\n14 O\nSydney B-ORG\nTigers I-ORG\n26 O\n\nNewcastle B-ORG\n24 O\nWestern B-ORG\nReds I-ORG\n20 O\n\nPlayed O\nFriday O\n: O\n\nCanberra B-ORG\n30 O\nAuckland B-ORG\n6 O\n\nPremiership O\nstandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\n\nlost O\n, O\npoints O\nfor O\n, O\nagainst O\n, O\ntotal O\npoints O\n) O\n: O\n\nManly B-ORG\n21 O\n17 O\n0 O\n4 O\n501 O\n181 O\n34 O\n\nBrisbane B-ORG\n21 O\n16 O\n0 O\n5 O\n569 O\n257 O\n32 O\n\nNorth B-ORG\nSydney I-ORG\n21 O\n14 O\n2 O\n5 O\n560 O\n317 O\n30 O\n\nSydney B-ORG\nCity I-ORG\n20 O\n14 O\n1 O\n5 O\n487 O\n293 O\n29 O\n\nCronulla B-ORG\n20 O\n12 O\n2 O\n6 O\n359 O\n258 O\n26 O\n\nCanberra B-ORG\n21 O\n12 O\n1 O\n8 O\n502 O\n374 O\n25 O\n\nSt B-ORG\nGeorge I-ORG\n21 O\n12 O\n1 O\n8 O\n421 O\n344 O\n25 O\n\nNewcastle B-ORG\n21 O\n11 O\n1 O\n9 O\n416 O\n366 O\n23 O\n\nWestern B-ORG\nSuburbs I-ORG\n21 O\n11 O\n1 O\n9 O\n382 O\n426 O\n23 O\n\nAuckland B-ORG\n21 O\n11 O\n0 O\n10 O\n406 O\n389 O\n22 O\n\nSydney B-ORG\nTigers I-ORG\n21 O\n11 O\n0 O\n10 O\n309 O\n435 O\n22 O\n\nParramatta B-ORG\n21 O\n10 O\n1 O\n10 O\n388 O\n391 O\n21 O\n\nSydney B-ORG\nBulldogs I-ORG\n21 O\n10 O\n0 O\n11 O\n325 O\n356 O\n20 O\n\nIllawarra B-ORG\n21 O\n8 O\n0 O\n13 O\n395 O\n432 O\n16 O\n\nWestern B-ORG\nReds I-ORG\n21 O\n6 O\n1 O\n14 O\n297 O\n398 O\n13 O\n\nPenrith B-ORG\n21 O\n6 O\n1 O\n14 O\n339 O\n448 O\n13 O\n\nNorth B-ORG\nQueensland I-ORG\n21 O\n6 O\n0 O\n15 O\n266 O\n593 O\n12 O\n\nGold B-ORG\nCoast I-ORG\n21 O\n5 O\n1 O\n15 O\n351 O\n483 O\n11 O\n\nSouth B-ORG\nSydney I-ORG\n21 O\n5 O\n1 O\n15 O\n304 O\n586 O\n11 O\n\nSouth B-ORG\nQueensland I-ORG\n21 O\n4 O\n0 O\n17 O\n210 O\n460 O\n8 O\n\n-DOCSTART- O\n\nBADMINTON O\n- O\nMALAYSIAN B-MISC\nOPEN I-MISC\nRESULTS O\n. O\n\nKUALA B-LOC\nLUMPUR I-LOC\n1996-08-25 O\n\nResults O\nof O\nfinals O\nin O\nthe O\n\nMalaysian B-MISC\nOpen I-MISC\nbadminton O\ntournament O\non O\nSunday O\n( O\nprefix O\nnumbers O\n\ndenote O\nseedings O\n) O\n: O\n\nMen O\n's O\nsingles O\n\n2 O\n- O\nOng B-PER\nEwe I-PER\nHock I-PER\n( O\nMalaysia B-LOC\n) O\nbeat O\nIndra B-PER\nWijaya I-PER\n( O\nIndonesia B-LOC\n) O\n1-15 O\n\n15-1 O\n15-7 O\n\nWomen O\n's O\nsingles O\n\n2 O\n- O\nZhang B-PER\nNing I-PER\n( O\nChina B-LOC\n) O\nbeat O\n1 O\n- O\nWang B-PER\nChen I-PER\n( O\nChina B-LOC\n) O\n11-7 O\n11-8 O\n\nWomen O\n's O\ndoubles O\n\n3/4 O\n- O\nMarlene B-PER\nThomsen I-PER\n/ O\nLisbet B-PER\nStuer-Lauridsen I-PER\n( O\nDenmark B-LOC\n) O\nbeat O\n\n3/4 O\n- O\nQiang B-PER\nHong I-PER\n/ O\nLiu B-PER\nLu I-PER\n( O\nChina B-LOC\n) O\n10-15 O\n17-14 O\n17-16 O\n\nMen O\n's O\ndoubles O\n\n1 O\n- O\nYap B-PER\nKim I-PER\nHock I-PER\n/ O\nCheah B-PER\nSoon I-PER\nKit I-PER\n( O\nMalaysia B-LOC\n) O\nbeat O\nLee B-PER\nWan I-PER\nWah I-PER\n/ O\nChong B-PER\n\nTan B-PER\nFook I-PER\n( O\nMalaysia B-LOC\n) O\n15-5 O\n15-3 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nRESULTS O\nOF O\nS. B-MISC\nKOREAN I-MISC\nPRO-BASEBALL O\nGAMES O\n. O\n\nSEOUL B-LOC\n1996-08-25 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\n\npro-baseball O\ngames O\nplayed O\non O\nSaturday O\n. O\n\nHaitai B-ORG\n10 O\nHanwha B-ORG\n4 O\n\nHyundai B-ORG\n5 O\nSamsung B-ORG\n4 O\n\nSsangbangwool B-ORG\n4 O\nLG B-ORG\n1 O\n\nOB B-ORG\n1 O\nLotte B-PER\n1 O\n\nLotte B-PER\n1 O\nOB B-ORG\n0* O\n\n*Note O\n- O\nOB B-ORG\nand O\nLotte B-PER\nplayed O\ntwo O\ngames O\n. O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nSaturday O\n( O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\n\nwinning O\npercentage O\n, O\ngames O\nbehind O\nfirst O\nplace O\n) O\n\nW O\nD O\nL O\nPCT O\nGB O\n\nHaitai B-ORG\n63 O\n2 O\n40 O\n.610 O\n- O\n\nSsangbangwool B-ORG\n57 O\n2 O\n47 O\n.547 O\n6 O\n1/2 O\n\nHyundai B-ORG\n55 O\n5 O\n47 O\n.537 O\n7 O\n1/2 O\n\nHanwha B-ORG\n55 O\n1 O\n48 O\n.534 O\n8 O\n\nSamsung B-ORG\n47 O\n5 O\n54 O\n.467 O\n15 O\n\nLotte B-ORG\n44 O\n6 O\n52 O\n.461 O\n15 O\n1/2 O\n\nLG B-ORG\n44 O\n5 O\n57 O\n.439 O\n18 O\n\nOB B-ORG\n40 O\n6 O\n60 O\n.406 O\n21 O\n1/2 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nSUNDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-25 O\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\n\nBaseball O\ngames O\nplayed O\non O\nSunday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nAmerican B-MISC\nLeague I-MISC\n\nBOSTON B-ORG\n8 O\nSeattle B-ORG\n5 O\n\nCLEVELAND B-ORG\n8 O\nMilwaukee B-ORG\n5 O\n\nCalifornia B-ORG\n13 O\nBALTIMORE B-ORG\n0 O\n\nOakland B-ORG\n6 O\nNEW B-ORG\nYORK I-ORG\n4 O\n\nCHICAGO B-ORG\n10 O\nToronto B-ORG\n9 O\n( O\n10 O\n) O\n\nTexas B-ORG\n13 O\nMINNESOTA B-ORG\n2 O\n\nDetroit B-ORG\n7 O\nKANSAS B-ORG\nCITY I-ORG\n4 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nSATURDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-25 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nSaturday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n74 O\n54 O\n.578 O\n- O\n\nBALTIMORE B-ORG\n68 O\n60 O\n.531 O\n6 O\n\nBOSTON B-ORG\n65 O\n65 O\n.500 O\n10 O\n\nTORONTO B-ORG\n61 O\n69 O\n.469 O\n14 O\n\nDETROIT B-ORG\n46 O\n83 O\n.357 O\n28 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n76 O\n53 O\n.589 O\n- O\n\nCHICAGO B-ORG\n69 O\n62 O\n.527 O\n8 O\n\nMINNESOTA B-ORG\n65 O\n64 O\n.504 O\n11 O\n\nMILWAUKEE B-ORG\n62 O\n68 O\n.477 O\n14 O\n1/2 O\n\nKANSAS B-ORG\nCITY I-ORG\n59 O\n72 O\n.450 O\n18 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n74 O\n56 O\n.569 O\n- O\n\nSEATTLE B-ORG\n66 O\n62 O\n.516 O\n7 O\n\nOAKLAND B-ORG\n62 O\n70 O\n.470 O\n13 O\n\nCALIFORNIA B-ORG\n60 O\n69 O\n.465 O\n13 O\n1/2 O\n\nSUNDAY O\n, O\nAUGUST O\n25TH O\nSCHEDULE O\n\nSEATTLE B-ORG\nAT O\nBOSTON B-LOC\n\nMILWAUKEE B-ORG\nAT O\nCLEVELAND B-LOC\n\nCALIFORNIA B-ORG\nAT O\nBALTIMORE B-LOC\n\nOAKLAND B-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nTORONTO B-ORG\nAT O\nCHICAGO B-LOC\n\nTEXAS B-ORG\nAT O\nMINNESOTA B-LOC\n\nDETROIT B-ORG\nAT O\nKANSAS B-LOC\nCITY I-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n81 O\n47 O\n.633 O\n- O\n\nMONTREAL B-ORG\n70 O\n58 O\n.547 O\n11 O\n\nFLORIDA B-ORG\n60 O\n70 O\n.462 O\n22 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n71 O\n.454 O\n23 O\n\nPHILADELPHIA B-ORG\n53 O\n77 O\n.408 O\n29 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nHOUSTON B-ORG\n69 O\n61 O\n.531 O\n- O\n\nST B-ORG\nLOUIS I-ORG\n68 O\n61 O\n.527 O\n1/2 O\n\nCINCINNATI B-ORG\n64 O\n64 O\n.500 O\n4 O\n\nCHICAGO B-ORG\n63 O\n64 O\n.496 O\n4 O\n1/2 O\n\nPITTSBURGH B-ORG\n55 O\n74 O\n.426 O\n13 O\n1/2 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n71 O\n60 O\n.542 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n69 O\n60 O\n.535 O\n1 O\n\nCOLORADO B-ORG\n67 O\n63 O\n.515 O\n3 O\n1/2 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n54 O\n73 O\n.425 O\n15 O\n\nSUNDAY O\n, O\nAUGUST O\n25TH O\nSCHEDULE O\n\nCHICAGO B-ORG\nAT O\nATLANTA B-LOC\n\nPITTSBURGH B-ORG\nAT O\nCOLORADO B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nLOS B-LOC\nANGELES I-LOC\n\nPHILADELPHIA B-ORG\nAT O\nSAN B-LOC\nDIEGO I-LOC\n\nMONTREAL B-ORG\nAT O\nSAN B-LOC\nFRANCISCO I-LOC\n\nCINCINNATI B-ORG\nAT O\nFLORIDA B-LOC\n\nST B-ORG\nLOUIS I-ORG\nAT O\nHOUSTON B-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nORIOLES B-ORG\nSNEAK O\nPAST O\nANGELS B-ORG\n. O\n\nBALTIMORE B-LOC\n1996-08-25 O\n\nRafael B-PER\nPalmeiro I-PER\n's O\ntwo-out O\nsingle O\nin O\nthe O\nsixth O\ninning O\nscored O\nRoberto B-PER\nAlomar I-PER\nwith O\nthe O\ngo-ahead O\nrun O\nas O\nthe O\nBaltimore B-ORG\nOrioles I-ORG\nrallied O\npast O\nthe O\nCalifornia B-ORG\nAngels I-ORG\n5-4 O\nand O\ntook O\nover O\nthe O\nAmerican B-MISC\nLeague I-MISC\n's O\nwild-card O\nberth O\non O\nSaturday O\n. O\n\nThe O\nOrioles B-ORG\ntrailed O\n4-3 O\nwhen O\npinch-hitter O\nMike B-PER\nDevereaux I-PER\nled O\noff O\nthe O\nsixth O\nwith O\na O\ntriple O\nagainst O\nreliever O\nKyle B-PER\nAbbott I-PER\n( O\n0-1 O\n) O\nand O\nscored O\nthe O\ntying O\nrun O\non O\nAlomar B-PER\n's O\nsingle O\n. O\n\nAfter O\nBrady B-PER\nAnderson I-PER\nsacrificed O\n, O\nPalmeiro B-PER\nhit O\nthe O\nfirst O\npitch O\ninto O\nright O\nfield O\nfor O\na O\nsingle O\n, O\nscoring O\nAlomar B-PER\n. O\n\nIn O\nBoston B-LOC\n, O\nformer O\nMariner B-PER\nDarren I-PER\nBragg I-PER\n's O\nfirst O\ncareer O\ngrand O\nslam O\nin O\nthe O\nsixth O\ninning O\noff O\nreliever O\nRandy B-PER\nJohnson I-PER\nlifted O\nthe O\nBoston B-ORG\nRed I-ORG\nSox I-ORG\nto O\ntheir O\nfifth O\nwin O\nin O\nsix O\ngames O\n, O\na O\n9-5 O\nvictory O\nover O\nSeattle B-LOC\n. O\n\n\" O\nJust O\none O\nof O\nthose O\nthings O\n, O\nI O\nwas O\njust O\ntrying O\nto O\nmake O\ncontact O\n, O\n\" O\nsaid O\nBragg B-PER\n. O\n\" O\n\nThe O\nbases O\nwere O\nloaded O\nand O\nI O\nhad O\ntwo O\nstrikes O\n. O\n\nI O\nwas O\njust O\ntrying O\nto O\nput O\nthe O\nball O\nin O\nplay O\n. O\n\nI O\ngot O\nthe O\ngood O\npart O\nof O\nthe O\nbat O\non O\nit O\nand O\nit O\ncarried O\nout O\n. O\n\" O\n\nIn O\nCleveland B-ORG\n, O\nKevin B-PER\nSeitzer I-PER\n's O\ntwo-out O\nsingle O\nin O\nthe O\ntop O\nof O\nthe O\n10th O\nbrought O\nhome O\nDavid B-PER\nHulse I-PER\nwith O\nthe O\nwinning O\nrun O\nas O\nthe O\nMilwaukee B-ORG\nBrewers I-ORG\nsent O\nthe O\nCleveland B-ORG\nIndians I-ORG\nto O\ntheir O\nthird O\nstraight O\nextra-inning O\ndefeat O\n4-3 O\n. O\n\nBob B-PER\nWickman I-PER\n( O\n5-1 O\n) O\n, O\nacquired O\nfrom O\nthe O\nNew B-ORG\nYork I-ORG\nYankees I-ORG\non O\nFriday O\n, O\nearned O\nthe O\nwin O\nin O\nhis O\nMilwaukee B-ORG\ndebut O\ndespite O\nallowing O\nthe O\ntying O\nrun O\nin O\nthe O\neighth O\ninning O\n. O\n\nAt O\nMinnesota B-LOC\n, O\nMarty B-PER\nCordova I-PER\nand O\nMatt B-PER\nLawton I-PER\nhit O\nsolo O\nhomers O\nand O\nFrankie B-PER\nRodriguez I-PER\nallowed O\nsix O\nhits O\nover O\nseven O\ninnings O\nto O\nearn O\nhis O\nfirst O\nwin O\nas O\na O\nstarter O\nin O\na O\nmonth O\nas O\nthe O\nMinnesota B-ORG\nTwins I-ORG\nheld O\non O\nto O\nbeat O\nthe O\nTexas B-ORG\nRangers I-ORG\n6-5 O\n. O\n\n\" O\nYeah O\n, O\nyou O\nknow O\nit O\n's O\nfun O\n, O\nit O\n's O\nalways O\nfun O\nwhen O\nyou O\n've O\ngot O\na O\nchance O\nto O\ngo O\nto O\nthe O\nballpark O\nand O\nwin O\na O\ngame O\nthat O\n's O\nimportant O\n, O\n\" O\nsaid O\nRodriguez B-PER\n. O\n\" O\n\nEvery O\ngame O\nshould O\nbe O\nimportant O\n, O\nbut O\nit O\n's O\na O\nlittle O\nmore O\nimportant O\nnow O\n. O\n\" O\n\nIn O\nNew B-LOC\nYork I-LOC\n, O\nWally B-PER\nWhitehurst I-PER\nallowed O\ntwo O\nruns O\nover O\nseven O\ninnings O\nfor O\nhis O\nfirst O\nwin O\nin O\nmore O\nthan O\ntwo O\nyears O\nand O\nPaul B-PER\nO'Neill I-PER\n's O\nthree-run O\ndouble O\nsnapped O\na O\nsixth-inning O\ntie O\nas O\nthe O\nNew B-ORG\nYork I-ORG\nYankees I-ORG\nheld O\non O\nfor O\na O\n5-4 O\nvictory O\nover O\nthe O\nOakland B-ORG\nAthletics I-ORG\n. O\n\nWhitehurst B-PER\n, O\npromoted O\nfrom O\nTriple-A B-ORG\nColumbus I-ORG\non O\nWednesday O\n, O\nallowed O\nseven O\nhits O\nand O\nstruck O\nout O\none O\nwithout O\na O\nwalk O\n. O\n\nIt O\nwas O\nhis O\nfirst O\nwin O\nsince O\ndefeating O\nthe O\nSt. B-ORG\nLouis I-ORG\nCardinals I-ORG\non O\nMay O\n28th O\n, O\n1994 O\nwhen O\nhe O\nwas O\nwith O\nthe O\nSan B-ORG\nDiego I-ORG\nPadres I-ORG\n. O\n\nIn O\nKansas B-LOC\nCity I-LOC\n, O\nJose B-PER\nRosado I-PER\ncame O\nwithin O\none O\nout O\nof O\nhis O\nthird O\ncomplete O\ngame O\nand O\nMichael B-PER\nTucker I-PER\nhomered O\nand O\ndrove O\nin O\nthree O\nruns O\nas O\nthe O\nKansas B-ORG\nCity I-ORG\nRoyals I-ORG\nbroke O\na O\nsix-game O\nlosing O\nstreak O\nwith O\na O\n9-2 O\nvictory O\nover O\nthe O\nDetroit B-ORG\nTigers I-ORG\nin O\na O\nbattle O\nof O\ncellar-dwellers O\n. O\n\nRosado B-PER\n( O\n5-3 O\n) O\nallowed O\ntwo O\nruns O\n-- O\none O\nearned O\n-- O\nand O\nseven O\nhits O\nover O\n8-2/3 O\ninnings O\nwith O\nthree O\nwalks O\nand O\nsix O\nstrikeouts O\n. O\n\nIn O\nhis O\nlast O\nfour O\nstarts O\n, O\nthe O\n21-year-old O\nleft-hander O\nhas O\ngiven O\nup O\nonly O\nfour O\nearned O\nruns O\nin O\n29-2/3 O\ninnings O\n. O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nBRAVES B-ORG\nRALLY O\nTO O\nBEAT O\nCUBS B-ORG\n. O\n\nATLANTA B-LOC\n1996-08-25 O\n\nFred B-PER\nMcGriff I-PER\nwent O\n5-for-5 O\nand O\nhomered O\ntwice O\n, O\nincluding O\na O\nthree-run O\nblast O\nwith O\ntwo O\nout O\nin O\nthe O\nbottom O\nof O\nthe O\nninth O\ninning O\nthat O\nlifted O\nthe O\nAtlanta B-ORG\nBraves I-ORG\nto O\na O\n6-5 O\nvictory O\nover O\nthe O\nChicago B-ORG\nCubs I-ORG\non O\nSaturday O\n. O\n\n\" O\nI O\nwas O\njust O\ntrying O\nto O\nhang O\nin O\nthere O\nand O\nhit O\nit O\nup O\nthe O\nmiddle O\n, O\n\" O\nsaid O\nMcGriff B-PER\nabout O\nhis O\nhomer O\nin O\nthe O\nninth O\n. O\n\" O\n\nI O\nwas O\njust O\nlooking O\nfor O\nthe O\nball O\n, O\ntrying O\nto O\nstay O\non O\nit O\n. O\n\nBrad B-PER\nClontz I-PER\n( O\n6-2 O\n) O\npicked O\nup O\nthe O\nwin O\nin O\nrelief O\nfor O\nAtlanta B-LOC\n, O\nwhich O\nhas O\nwon O\n11 O\nof O\nits O\nlast O\n13 O\ngames O\n. O\n\nIn O\nColorado B-LOC\n, O\nMark B-PER\nThompson I-PER\nthrew O\nan O\neight-hitter O\nfor O\nhis O\nthird O\ncomplete O\ngame O\nand O\nEllis B-PER\nBurks I-PER\nhomered O\nand O\ndrove O\nin O\nthree O\nruns O\nas O\nthe O\nColorado B-ORG\nRockies I-ORG\nbeat O\nthe O\nPittsburgh B-ORG\nPirates I-ORG\n9-3 O\n. O\n\nVinny B-PER\nCastilla I-PER\nand O\nDante B-PER\nBichette I-PER\neach O\nadded O\ntwo O\nRBI B-MISC\nfor O\nColorado B-LOC\n, O\nwhich O\nimproved O\nthe O\nmajor O\nleague O\n's O\nbest O\nhome O\nmark O\nto O\n44-20 O\n. O\n\nAt O\nFlorida B-LOC\n, O\nKevin B-PER\nBrown I-PER\nscattered O\nseven O\nhits O\nover O\neight O\ninnings O\nand O\nKurt B-PER\nAbbott I-PER\nsnapped O\na O\nsixth-inning O\ntie O\nwith O\na O\ntwo-run O\ndouble O\nas O\nthe O\nFlorida B-ORG\nMarlins I-ORG\ndefeated O\nthe O\ntired O\nCincinnati B-ORG\nReds I-ORG\n5-3 O\n. O\n\nThe O\nMarlins B-ORG\nwon O\nfor O\njust O\nthe O\nthird O\ntime O\nin O\nnine O\ngames O\n, O\ntaking O\nadvantage O\nof O\na O\nReds B-ORG\n' O\nteam O\nthat O\nhas O\nnot O\nhad O\na O\nday O\noff O\nsince O\nAugust O\n8th O\nand O\nwas O\nplaying O\nits O\nfourth O\ngame O\nin O\n43 O\nhours O\n. O\n\nIn O\nLos B-LOC\nAngeles I-LOC\n, O\nTom B-PER\nCandiotti I-PER\nallowed O\ntwo O\nruns O\nin O\nseven O\ninnings O\nand O\nsingled O\nhome O\nthe O\ngo-ahead O\nrun O\nand O\nMike B-PER\nPiazza I-PER\nand O\nTodd B-PER\nHollandsworth I-PER\ndrove O\nin O\ntwo O\nruns O\napiece O\nas O\nthe O\nLos B-ORG\nAngeles I-ORG\nDodgers I-ORG\ndefeated O\nthe O\nNew B-ORG\nYork I-ORG\nMets I-ORG\n7-5 O\n. O\n\nCandiotti B-PER\n( O\n8-9 O\n) O\nwalked O\none O\n, O\nallowed O\nfive O\nhits O\nand O\nstruck O\nout O\na O\nseason-high O\neight O\nbatters O\nfor O\nLos B-LOC\nAngeles I-LOC\n, O\nwhich O\nhas O\nwon O\n10 O\nof O\nits O\nlast O\n14 O\ngames O\n. O\n\nIn O\nSan B-LOC\nDiego I-LOC\n, O\nJoey B-PER\nHamilton I-PER\nallowed O\ntwo O\nhits O\nover O\nseven O\ninnings O\nand O\nRickey B-PER\nHenderson I-PER\nhit O\nhis O\nmajor O\nleague-record O\n69th O\nleadoff O\nhomer O\nas O\nthe O\nSan B-ORG\nDiego I-ORG\nPadres I-ORG\ndefeated O\nthe O\nPhiladelphia B-ORG\nPhillies I-ORG\n7-1 O\nfor O\ntheir O\nfifth O\nwin O\nin O\nsix O\ngames O\n. O\n\nHamilton B-PER\n( O\n12-7 O\n) O\nwon O\nhis O\nsecond O\nstraight O\nstart O\n, O\nallowing O\njust O\na O\nsixth-inning O\nrun O\nand O\na O\npair O\nof O\nsingles O\n. O\n\nIn O\nSan B-LOC\nFrancisco I-LOC\n, O\nPedro B-PER\nMartinez I-PER\nallowed O\ntwo O\nhits O\nin O\neight O\ninnings O\nand O\nDavid B-PER\nSegui I-PER\ndrove O\nin O\ntwo O\nruns O\nas O\nthe O\nMontreal B-ORG\nExpos I-ORG\nshut O\nout O\nthe O\nSan B-ORG\nFrancisco I-ORG\nGiants I-ORG\n3-0 O\nfor O\ntheir O\nthird O\nstraight O\nwin O\n. O\n\nMartinez B-PER\n( O\n11-7 O\n) O\n, O\nwho O\nlasted O\njust O\n1-1/3 O\ninnings O\nin O\nhis O\nlast O\nstart O\nagainst O\nSan B-LOC\nDiego I-LOC\nfive O\ndays O\nago O\n, O\npitched O\neight-plus O\ninnings O\n, O\nwalking O\nfour O\nand O\nstriking O\nout O\n10 O\n. O\n\nIn O\nHouston B-LOC\n, O\nOrlando B-PER\nMiller I-PER\n's O\ntwo-run O\nhomer O\nwith O\none O\nout O\nin O\nthe O\nbottom O\nof O\nthe O\nninth O\noff O\nTodd B-PER\nStottlemyre I-PER\ngave O\nthe O\nHouston B-ORG\nAstros I-ORG\na O\n3-1 O\nwin O\nover O\nthe O\nSt. B-ORG\nLouis I-ORG\nCardinals I-ORG\nand O\nleft O\nthe O\nteams O\nin O\na O\nvirtual O\ntie O\nfor O\nthe O\nlead O\nin O\nthe O\nNL B-MISC\nCentral I-MISC\ndivision I-MISC\n. O\n\nShane B-PER\nReynolds I-PER\n( O\n16-6 O\n) O\nfired O\na O\nfive-hitter O\n, O\nwalking O\none O\nand O\nstriking O\nout O\nsix O\n. O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nSATURDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-25 O\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\n\nBaseball O\ngames O\nplayed O\non O\nSaturday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nNational B-MISC\nLeague I-MISC\n\nATLANTA B-ORG\n6 O\nChicago B-ORG\n5 O\n\nHOUSTON B-ORG\n3 O\nSt B-ORG\nLouis I-ORG\n1 O\n\nLOS B-ORG\nANGELES I-ORG\n7 O\nNew B-ORG\nYork I-ORG\n5 O\n\nMontreal B-ORG\n3 O\nSAN B-ORG\nFRANCISCO I-ORG\n0 O\n\nFLORIDA B-ORG\n5 O\nCincinnati B-ORG\n3 O\n\nCOLORADO B-ORG\n9 O\nPittsburgh B-ORG\n3 O\n\nSAN B-ORG\nDIEGO I-ORG\n7 O\nPhiladelphia B-ORG\n1 O\n\nAmerican B-MISC\nLeague I-MISC\n\nBOSTON B-ORG\n9 O\nSeattle B-ORG\n5 O\n\nMilwaukee B-ORG\n4 O\nCLEVELAND B-ORG\n3 O\n( O\n10 O\ninnings O\n) O\n\nBALTIMORE B-ORG\n5 O\nCalifornia B-ORG\n4 O\n\nToronto B-ORG\n9 O\nCHICAGO B-ORG\n2 O\n\nNEW B-ORG\nYORK I-ORG\n5 O\nOakland B-ORG\n4 O\n\nKANSAS B-ORG\nCITY I-ORG\n9 O\nDetroit B-ORG\n2 O\n\nMINNESOTA B-ORG\n6 O\nTexas B-ORG\n5 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nCHAMPIONS O\nPORTO B-LOC\nKICK O\nOFF O\nSEASON O\nWITH O\nA O\nDRAW O\n. O\n\nLISBON B-LOC\n1996-08-25 O\n\nPortuguese B-MISC\nchampions O\nPorto B-ORG\nkicked O\noff O\nthe O\nseason O\nwith O\na O\ndisappointing O\n2-2 O\nhome O\ndraw O\nagainst O\nSetubal B-ORG\nand O\nwere O\nlucky O\nto O\nsqueeze O\nin O\nan O\nequaliser O\nin O\nextra O\ntime O\n. O\n\nPorto B-ORG\n, O\nwho O\nare O\nfighting O\nto O\ntake O\ntheir O\nthird O\nconsecutive O\ntitle O\nthis O\nseason O\n, O\nwere O\n2-0 O\ndown O\nuntil O\nthe O\n86th O\nminute O\nwhen O\na O\nheader O\nby O\nMario B-PER\nJardel I-PER\nfound O\nthe O\nnet O\nafter O\na O\nstring O\nof O\nmissed O\nopportunities O\n, O\nincluding O\na O\npenalty O\ntaken O\nby O\ntop O\nleague O\nscorer O\nDomingos B-PER\nOliveira I-PER\nin O\nthe O\n60th O\nminute O\n. O\n\nDomingos B-PER\nredeemed O\nhimself O\nby O\nnetting O\nthe O\nequaliser O\njust O\ninto O\nextra O\ntime O\n. O\n\nSetubal B-ORG\n, O\nwho O\nput O\non O\na O\nskilful O\ncounter-attack O\nthroughout O\nthe O\ngame O\n, O\nopened O\nthe O\nscoring O\n16 O\nminutes O\ninto O\nthe O\nmatch O\nwhen O\nan O\nunmarked O\nChiquinho B-PER\nConde I-PER\nshot O\naround O\nPorto B-ORG\n's O\nnew O\nPolish B-MISC\nkeeper O\nAndrejez B-PER\nWozniak I-PER\n. O\n\nConde B-PER\nscored O\nhis O\nsecond O\nin O\nthe O\n70th O\nminute O\n. O\n\nBenfica B-ORG\n, O\nalso O\nplaying O\ntheir O\nfirst O\ngame O\nof O\nthe O\nseason O\nat O\nhome O\n, O\nwere O\nheld O\nto O\na O\n1-1 O\ndraw O\nby O\nnorthern O\nside O\nBraga B-ORG\ndespite O\nthe O\nfact O\nthat O\nthe O\nvisitors O\nwere O\nreduced O\nto O\n10 O\nmen O\nin O\nthe O\n54th O\nminute O\nafter O\nRodrigo B-PER\nCarneiro I-PER\nwas O\nsent O\noff O\nfor O\na O\nsecond O\nbookable O\noffence O\n. O\n\nBenfica B-ORG\ndominated O\nthe O\ngame O\nbut O\ntheir O\nlack O\nof O\na O\nfirst-class O\nstriker O\nwas O\napparent O\nthroughout O\nand O\nin O\nthe O\n30th O\nminute O\nthey O\nlost O\nkey O\nBrazilian B-MISC\nmidfielder O\nValdo B-PER\nwho O\nsuffered O\na O\nlight O\nknee O\ninjury O\n. O\n\nHe O\nwas O\nsubstituted O\nby O\nPaulao B-PER\n. O\n\nBenfica B-ORG\nfinally O\nopened O\nthe O\nscoring O\nin O\nthe O\n81st O\nminute O\nwith O\na O\npenalty O\ntaken O\nby O\nHelder B-PER\nafter O\nLuis B-PER\nBaltasar I-PER\ntripped O\nup O\ncaptain O\nJoao B-PER\nPinto I-PER\nunder O\nthe O\nreferee O\n's O\nnose O\n. O\n\nBraga B-ORG\ndefender O\nIdalecio B-PER\ngave O\nhis O\nteam O\ntheir O\nequaliser O\nseven O\nminutes O\nfrom O\nthe O\nfinal O\nwhistle O\nwith O\na O\nheader O\ninto O\nthe O\nback O\nof O\nthe O\nnet O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPORTUGUESE B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n. O\n\nLISBON B-LOC\n1996-08-25 O\n\nResults O\nof O\nPortuguese B-MISC\nfirst O\n\ndivision O\nsoccer O\nmatches O\non O\nSunday O\n: O\n\nFC B-ORG\nPorto I-ORG\n2 O\nSetubal B-ORG\n2 O\n\nBenfica B-ORG\n1 O\nBraga B-ORG\n1 O\n\nGuimaraes B-ORG\n4 O\nGil B-ORG\nVicente I-ORG\n2 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFIORENTINA B-ORG\nWIN O\nWITH O\nBATISTUTA B-PER\nDOUBLE O\n. O\n\nMILAN B-LOC\n1996-08-25 O\n\nArgentine B-MISC\nstriker O\nGabriel B-PER\nBatistuta I-PER\ngave O\nFiorentina B-ORG\nthe O\nperfect O\n70th O\nbirthday O\npresent O\non O\nSunday O\nwith O\ntwo O\ngoals O\nthat O\ngave O\nthe O\nItalian B-MISC\nCup I-MISC\nwinners O\na O\n2-1 O\nSupercup B-MISC\nvictory O\nover O\nserie B-MISC\nA I-MISC\nchampions O\nMilan B-ORG\n. O\n\nThe O\nvictory O\n, O\ncoming O\non O\nthe O\neve O\nof O\nthe O\nfounding O\nof O\nthe O\nFlorence B-LOC\nclub O\nin O\n1926 O\n, O\nalso O\nmarked O\nthe O\nfirst O\ntime O\nsince O\nthe O\npre-season O\ntrophy O\nbetween O\nthe O\nCup B-MISC\nwinners O\nand O\nleague O\nchampions O\nwas O\nstarted O\nin O\n1988 O\nthat O\nthe O\nCup B-MISC\nwinners O\nhad O\nwon O\n. O\n\nBatistuta B-PER\ngave O\nFiorentina B-ORG\nthe O\nlead O\nin O\nthe O\n11th O\nminute O\n. O\n\nSweden B-LOC\n's O\nStefan B-PER\nSchwarz I-PER\npicked O\nhim O\nout O\nwith O\na O\nlob O\nto O\nthe O\nedge O\nof O\nthe O\nbox O\nand O\nBatistuta B-PER\ndid O\nthe O\nrest O\n, O\nchipping O\nveteran O\ndefender O\nFranco B-PER\nBaresi I-PER\nand O\nscoring O\nat O\nthe O\nnear O\npost O\n. O\n\nMontenegrin B-MISC\nmidfielder O\nDejan B-PER\nSavicevic I-PER\nequalised O\nfor O\nthe O\nhome O\nteam O\n, O\nweaving O\npast O\na O\ndefender O\n, O\nchecking O\nand O\nfiring O\nin O\na O\nleft-footed O\nshot O\nin O\nthe O\n21st O\nminute O\nthat O\ngave O\nyoung O\nFiorentina B-ORG\ngoalkeeper O\nFrancesco B-PER\nToldo I-PER\nlittle O\nchance O\n. O\n\nThe O\nscored O\nstayed O\nlevel O\nto O\nthe O\nfinal O\nminutes O\nbut O\nwith O\na O\npenalty O\nshoot O\nout O\nlooming O\n, O\nBatistuta B-PER\ntook O\ncharge O\n. O\n\nFrench B-MISC\ninternational O\nmidfielder O\nMarcel B-PER\nDesailly I-PER\nfouled O\nthe O\nArgentine B-MISC\n, O\nwhose O\ncoach O\nat O\nBoca B-ORG\nJuniors I-ORG\nbefore O\nhe O\njoined O\nFiorentina B-ORG\nin O\n1991 O\nwas O\nnew O\nMilan B-ORG\ncoach O\nOscar B-PER\nTabarez I-PER\n, O\nand O\nBatistuta B-PER\nrammed O\nhome O\nthe O\nfree O\nkick O\nfrom O\n30 O\nmetres O\nout O\n. O\n\nThe O\n83rd O\nminute O\nshot O\n, O\ncurling O\nover O\nthe O\ndefence O\nand O\ndipping O\nin O\nunder O\nthe O\nbar O\nfrom O\nthe O\nstriker O\ndubbed O\nBatigol B-PER\nby O\nadoring O\nFiorentina B-ORG\nfans O\n, O\nwas O\njust O\nreward O\nfor O\nFiorentina B-ORG\nwho O\nlooked O\na O\nfar O\nmore O\nimpressive O\nteam O\n. O\n\nMilan B-ORG\n's O\nplayer O\nof O\nthe O\nyear O\nGeorge B-PER\nWeah I-PER\nmissed O\na O\ngood O\nfirst O\nhalf O\nopportunity O\nbut O\notherwise O\nlooked O\na O\nlittle O\nrusty O\nwhile O\nItalian B-MISC\nteam O\nmate O\nRoberto B-PER\nBaggio I-PER\ndid O\nnot O\nplay O\ndue O\nto O\ninjury O\n. O\n\nNew O\nDutch B-MISC\nsigning O\nEdgar B-PER\nDavids I-PER\ncame O\non O\nlate O\nin O\nthe O\nsecond O\nhalf O\nas O\na O\nMilan B-ORG\nsubstitute O\nbut O\nmade O\nlittle O\nimpact O\n. O\n\nThe O\nleague O\nseason O\nstarts O\non O\nSeptember O\n8 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFIORENTINA B-ORG\nBEAT O\nMILAN B-ORG\nIN O\nITALIAN B-MISC\nSUPERCUP I-MISC\n. O\n\nMILAN B-LOC\n1996-08-25 O\n\nItalian B-MISC\nCup B-MISC\nwinners O\nFiorentina B-ORG\nbeat O\n\nleague O\nchampions O\nMilan B-ORG\n2-1 O\n( O\nhalftime O\n1-1 O\n) O\nin O\nthe O\npre-season O\n\nSupercoppa O\n( O\nSuperCup B-MISC\n) O\nin O\nMilan B-LOC\non O\nSunday O\n: O\n\nScorers O\n: O\n\nFiorentina B-ORG\n- O\nGabriel B-PER\nBatistuta I-PER\n( O\n11th O\n, O\n83rd O\n) O\n\nMilan B-ORG\n- O\nDejan B-PER\nSavicevic I-PER\n( O\n21st O\n) O\n\nAttendance O\n: O\n29,582 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nNORWAY B-LOC\nELITE O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nOSLO B-LOC\n1996-08-25 O\n\nResults O\nof O\nNorwegian B-MISC\nelite O\ndivision O\n\nsoccer O\nmatches O\nat O\nthe O\nweekend O\n: O\n\nTromso B-ORG\n2 O\nKongsvinger B-ORG\n1 O\n\nValerenga B-ORG\n3 O\nSkeid B-ORG\n0 O\n\nStabaek B-ORG\n4 O\nStromsgodset B-ORG\n0 O\n\nMolde B-ORG\n1 O\nBodo B-ORG\n/ I-ORG\nGlimt I-ORG\n2 O\n\nViking B-ORG\n1 O\nMoss B-ORG\n0 O\n\nBrann B-ORG\n7 O\nStart B-ORG\n1 O\n\nRosenborg B-ORG\n7 O\nLillestrom B-ORG\n2 O\n\nStandings O\nafter O\nweekend O\nmatches O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\n\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nRosenborg B-ORG\n20 O\n14 O\n4 O\n2 O\n68 O\n21 O\n46 O\n\nLillestrom B-ORG\n19 O\n9 O\n5 O\n5 O\n38 O\n29 O\n32 O\n\nSkeid B-ORG\n19 O\n10 O\n2 O\n7 O\n29 O\n30 O\n32 O\n\nStabaek B-ORG\n20 O\n7 O\n8 O\n5 O\n41 O\n34 O\n29 O\n\nBrann B-ORG\n19 O\n8 O\n5 O\n6 O\n40 O\n37 O\n29 O\n\nTromso B-ORG\n20 O\n8 O\n5 O\n7 O\n34 O\n33 O\n29 O\n\nViking B-ORG\n20 O\n7 O\n7 O\n6 O\n33 O\n24 O\n28 O\n\nMolde B-ORG\n19 O\n8 O\n3 O\n8 O\n36 O\n25 O\n27 O\n\nBodo B-ORG\n/ I-ORG\nGlimt I-ORG\n20 O\n7 O\n4 O\n9 O\n33 O\n41 O\n25 O\n\nKongsvinger B-ORG\n20 O\n7 O\n4 O\n9 O\n26 O\n38 O\n25 O\n\nStromsgodset B-ORG\n20 O\n7 O\n4 O\n9 O\n27 O\n40 O\n25 O\n\nValerenga B-ORG\n20 O\n6 O\n6 O\n8 O\n26 O\n32 O\n24 O\n\nMoss B-ORG\n20 O\n4 O\n6 O\n10 O\n23 O\n40 O\n18 O\n\nStart B-ORG\n20 O\n3 O\n3 O\n14 O\n26 O\n56 O\n12 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSUMMARY O\nOF O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nMATCH O\n. O\n\nBONN B-LOC\n1996-08-25 O\n\nSummary O\nof O\nGerman B-MISC\nfirst O\ndivision O\n\nmatch O\nplayed O\non O\nSunday O\n: O\n\nMSV B-ORG\nDuisberg I-ORG\n0 O\nBayern B-ORG\nMunich I-ORG\n4 O\n( O\nKlinsmann B-PER\n15th O\n, O\nZieger B-PER\n24th O\nand O\n\n90th O\n, O\nWitechek B-PER\n59th O\n) O\n. O\n\nHalftime O\n0-2 O\n. O\n\nAttendance O\n: O\n30,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nRESULT O\nOF O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nMATCH O\n. O\n\nBONN B-LOC\n1996-08-25 O\n\nResult O\nof O\nGerman B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatch O\non O\nSunday O\n: O\n\nMSV B-ORG\nDuisberg I-ORG\n0 O\nBayern B-ORG\nMunich I-ORG\n4 O\n\nBundesliga B-MISC\nstandings O\nafter O\nSunday O\n's O\ngame O\n( O\ntabulate O\nunder O\n\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nCologne B-ORG\n3 O\n3 O\n0 O\n0 O\n7 O\n1 O\n9 O\n\nBayern B-ORG\nMunich I-ORG\n3 O\n2 O\n1 O\n0 O\n7 O\n2 O\n7 O\n\nVfB B-ORG\nStuttgart I-ORG\n2 O\n2 O\n0 O\n0 O\n6 O\n1 O\n6 O\n\nBorussia B-ORG\nDortmund I-ORG\n3 O\n2 O\n0 O\n1 O\n9 O\n5 O\n6 O\n\nHamburg B-ORG\n3 O\n2 O\n0 O\n1 O\n7 O\n3 O\n6 O\n\nBayer B-ORG\nLeverkusen I-ORG\n3 O\n2 O\n0 O\n1 O\n7 O\n4 O\n6 O\n\nVfL B-ORG\nBochum I-ORG\n3 O\n1 O\n2 O\n0 O\n3 O\n2 O\n5 O\n\nKarlsruhe B-ORG\n2 O\n1 O\n1 O\n0 O\n5 O\n3 O\n4 O\n\nSt B-ORG\nPauli I-ORG\n3 O\n1 O\n1 O\n1 O\n7 O\n7 O\n4 O\n\n1860 B-ORG\nMunich I-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n5 O\n3 O\n\nFreiburg B-ORG\n3 O\n1 O\n0 O\n2 O\n5 O\n10 O\n3 O\n\nFortuna B-ORG\nDuesseldorf I-ORG\n3 O\n1 O\n0 O\n2 O\n1 O\n7 O\n3 O\n\nHansa B-ORG\nRostock I-ORG\n3 O\n0 O\n2 O\n1 O\n3 O\n4 O\n2 O\n\nArminia B-ORG\nBielefeld I-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n3 O\n2 O\n\nBorussia B-ORG\nMoenchengladbach I-ORG\n3 O\n0 O\n2 O\n1 O\n1 O\n3 O\n2 O\n\nSchalke B-ORG\n3 O\n0 O\n2 O\n1 O\n4 O\n8 O\n2 O\n\nWerder B-ORG\nBremen I-ORG\n3 O\n0 O\n1 O\n2 O\n4 O\n6 O\n1 O\n\nMSV B-ORG\nDuisburg I-ORG\n3 O\n0 O\n0 O\n3 O\n1 O\n8 O\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSWISS B-MISC\nPREMIER O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nGENEVA B-LOC\n1996-08-25 O\n\nResults O\nof O\nSwiss B-MISC\npremier O\ndivision O\n\nmatches O\nplayed O\nat O\nthe O\nweekend O\n: O\n\nAarau B-ORG\n1 O\nYoung B-ORG\nBoys I-ORG\n0 O\n\nGrasshopper B-ORG\n2 O\nLucerne B-ORG\n2 O\n\nLugano B-ORG\n1 O\nBasle B-ORG\n1 O\n\nNeuchatel B-ORG\n3 O\nSt B-ORG\nGallen I-ORG\n0 O\n\nSion B-ORG\n3 O\nServette B-ORG\n1 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nNeuchatel B-ORG\n8 O\n6 O\n1 O\n1 O\n12 O\n7 O\n19 O\n\nGrasshopper B-ORG\n9 O\n4 O\n4 O\n1 O\n17 O\n11 O\n16 O\n\nSt. B-ORG\nGallen O\n9 O\n4 O\n4 O\n1 O\n6 O\n5 O\n16 O\n\nLausanne B-ORG\n9 O\n4 O\n2 O\n3 O\n18 O\n13 O\n14 O\n\nAarau B-ORG\n8 O\n4 O\n1 O\n3 O\n9 O\n4 O\n13 O\n\nSion B-ORG\n9 O\n3 O\n4 O\n2 O\n13 O\n11 O\n13 O\n\nZurich B-ORG\n9 O\n2 O\n5 O\n2 O\n9 O\n9 O\n11 O\n\nBasle B-ORG\n8 O\n2 O\n3 O\n3 O\n12 O\n11 O\n9 O\n\nServette B-ORG\n9 O\n2 O\n3 O\n4 O\n10 O\n12 O\n9 O\n\nLucerne B-ORG\n8 O\n1 O\n5 O\n2 O\n10 O\n11 O\n8 O\n\nLugano B-ORG\n9 O\n1 O\n4 O\n4 O\n6 O\n15 O\n7 O\n\nYoung B-ORG\nBoys I-ORG\n9 O\n1 O\n0 O\n8 O\n6 O\n19 O\n3 O\n\n-DOCSTART- O\n\nGOLF O\n- O\nLEADING O\nPRIZE O\nMONEY O\nWINNERS O\nON O\nEUROPEAN B-MISC\nTOUR I-MISC\n. O\n\nSTUTTGART B-LOC\n, O\nGermany B-LOC\n1996-08-25 O\n\nLeading O\nprize O\nmoney O\n\nwinners O\non O\nthe O\nEuropean B-MISC\nTour I-MISC\nafter O\nSunday O\n's O\nGerman B-MISC\nOpen I-MISC\n( O\nBritain B-LOC\n\nunless O\nstated O\n) O\n: O\n\n1. O\nIan B-PER\nWoosnam I-PER\n480,618 O\npounds O\nsterling O\n\n2. O\nColin B-PER\nMontgomerie I-PER\n429,449 O\n\n3. O\nLee B-PER\nWestwood I-PER\n301,972 O\n\n4. O\nRobert B-PER\nAllenby I-PER\n( O\nAustralia B-LOC\n) O\n291,088 O\n\n5. O\nMark B-PER\nMcNulty I-PER\n( O\nZimbabwe B-LOC\n) O\n254,247 O\n\n6. O\nCostantino B-PER\nRocca I-PER\n( O\nItaly B-LOC\n) O\n253,337 O\n\n7. O\nAndrew B-PER\nColtart I-PER\n246,077 O\n\n8. O\nWayne B-PER\nRiley I-PER\n( O\nAustralia B-LOC\n) O\n233,713 O\n\n9. O\nRaymond B-PER\nRussell I-PER\n229,360 O\n\n10. O\nStephen B-PER\nAmes I-PER\n( O\nTrinidad B-LOC\n) O\n211,175 O\n\n11. O\nFrank B-PER\nNobilo I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n209,412 O\n\n12. O\nPaul B-PER\nMcGinley I-PER\n( O\nIreland B-LOC\n) O\n208,978 O\n\n13. O\nPaul B-PER\nLawrie I-PER\n207,990 O\n\n14. O\nPadraig B-PER\nHarrington I-PER\n( O\nIreland B-LOC\n) O\n202,593 O\n\n15. O\nRetief B-PER\nGoosen I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n188,143 O\n\n16. O\nJonathan B-PER\nLomas I-PER\n181,005 O\n\n17. O\nPaul B-PER\nBroadhurst I-PER\n172,580 O\n\n18. O\nPeter B-PER\nMitchell I-PER\n170,952 O\n\n19. O\nJim B-PER\nPayne I-PER\n165,150 O\n\n20. O\nRussell B-PER\nClaydon I-PER\n156,996 O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nSWISS B-MISC\nGRAND B-MISC\nPRIX I-MISC\nRESULT O\n. O\n\nZURICH B-LOC\n1996-08-25 O\n\nLeading O\nresults O\nin O\nthe O\n232-km O\n\nSwiss B-MISC\nGrand B-MISC\nPrix I-MISC\nWorld B-MISC\nCup I-MISC\ncycling O\nrace O\non O\nSunday O\n: O\n\n1. O\nAndrea B-PER\nFerrigato I-PER\n( O\nItaly B-LOC\n) O\n5 O\nhours O\n51 O\nminutes O\n52 O\nseconds O\n\n2. O\nMichele B-PER\nBartoli I-PER\n( O\nItaly B-LOC\n) O\n\n3. O\nJohan B-PER\nMuseeuw I-PER\n( O\nBelgium B-LOC\n) O\n\n4. O\nLance B-PER\nArmstrong I-PER\n( O\nU.S. B-LOC\n) O\n\n5. O\nFrancesco B-PER\nCasagrande I-PER\n( O\nItaly B-LOC\n) O\n\n6. O\nAlessandro B-PER\nBaronti I-PER\n( O\nItaly B-LOC\n) O\n\n7. O\nFrank B-PER\nVandenbroucke I-PER\n( O\nBelgium B-LOC\n) O\nall O\nsame O\ntime O\n\n8. O\nFabio B-PER\nBaldato I-PER\n( O\nItaly B-LOC\n) O\n11 O\nseconds O\nbehind O\n\n9. O\nMaurizio B-PER\nFondriest I-PER\n( O\nItaly B-LOC\n) O\n\n10. O\nLaurent B-PER\nJalabert I-PER\n( O\nFrance B-LOC\n) O\nboth O\nsame O\ntime O\n\nLeading O\nWorld B-MISC\nCup I-MISC\nstandings O\n( O\nafter O\n8 O\nof O\n11 O\nrounds O\n) O\n: O\n\n1. O\nMuseeuw B-PER\n162 O\npoints O\n\n2. O\nFerrigato B-PER\n112 O\n\n3. O\nBartoli B-PER\n108 O\n\n4. O\nStefano B-PER\nZanini I-PER\n( O\nItaly B-LOC\n) O\n88 O\n\n5. O\nArmstrong B-PER\n81 O\n\n6. O\nBaldato B-PER\n77 O\n\n7. O\nAlexandre B-PER\nGontchenkov I-PER\n( O\nUkraine B-LOC\n) O\n67 O\n\n8. O\nGabriele B-PER\nColombo I-PER\n( O\nItaly B-LOC\n) O\n58 O\n\n9. O\nAndrei B-PER\nTchmil I-PER\n( O\nUkraine B-LOC\n) O\n56 O\n\n10. O\nMax B-PER\nSciandri I-PER\n( O\nBritain B-LOC\n) O\n55 O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nFERRIGATO B-PER\nSPRINTS O\nTO O\nSECOND O\nSTRAIGHT O\nWORLD B-MISC\nCUP I-MISC\nWIN O\n. O\n\nZURICH B-LOC\n1996-08-25 O\n\nAndrea B-PER\nFerrigato I-PER\nof O\nItaly B-LOC\nsprinted O\nto O\nhis O\nsecond O\ncycling O\nWorld B-MISC\nCup I-MISC\nwin O\nin O\nsuccessive O\nweekends O\nwith O\nvictory O\nin O\nthe O\nSwiss B-MISC\nGrand B-MISC\nPrix I-MISC\non O\nSunday O\n. O\n\nFerrigato B-PER\n, O\nwinner O\nof O\nthe O\nLeeds B-MISC\nClassic I-MISC\nlast O\nSunday O\nwith O\na O\none O\nsecond O\nwin O\nover O\nBritain B-LOC\n's O\nMax B-PER\nSciandri I-PER\n, O\nposted O\na O\nsimilarly O\nnarrow O\nmargin O\nof O\nvictory O\nagain O\n. O\n\nThe O\n26-year-old O\nItalian B-MISC\nsurged O\npast O\ncompatriot O\nMichele B-PER\nBartoli I-PER\nand O\nlast O\nyear O\n's O\nwinner O\nand O\ndefending O\nWorld B-MISC\nCup I-MISC\nchampion O\nJohan B-PER\nMuseeuw I-PER\nof O\nBelgium B-LOC\nin O\nthe O\nfinal O\nfew O\nmetres O\nof O\nthe O\n237km O\nrace O\n. O\n\nAll O\nthree O\nclocked O\nthe O\nsame O\ntime O\nof O\nfive O\nhours O\n51 O\nminutes O\n, O\n52 O\nseconds O\n. O\n\nFormer O\nworld O\nchampion O\nLance B-PER\nArmstrong I-PER\nof O\nthe O\nUnited B-LOC\nStates I-LOC\nwas O\nin O\nfront O\nas O\nthe O\nleading O\npack O\nof O\nseven O\nriders O\nturned O\ninto O\nthe O\nOerlikon B-LOC\nvelodrome O\nfor O\nthe O\nfinal O\none O\nlap O\nsprint O\nbut O\nquickly O\nfaded O\nand O\nsettled O\nfor O\nfourth O\n. O\n\nThe O\nback-to-back O\nwins O\nvault O\nFerrigato B-PER\nfrom O\nsixth O\nto O\nsecond O\nin O\nthe O\noverall O\nWorld B-MISC\nCup I-MISC\nrankings O\nwith O\n112 O\npoints O\nbut O\nMuseeuw B-PER\ncontinues O\nto O\nhold O\na O\ncommanding O\nlead O\nwith O\n162 O\npoints O\nafter O\neight O\nof O\nthe O\n11 O\nrounds O\n. O\n\n-DOCSTART- O\n\nGOLF B-LOC\n- O\nGERMAN B-MISC\nOPEN I-MISC\nSCORES O\n. O\n\nSTUTTGART B-LOC\n, O\nGermany B-LOC\n1996-08-25 O\n\nBriton B-MISC\nIan B-PER\nWoosnam I-PER\nwon O\n\nthe O\nGerman B-MISC\nOpen I-MISC\ngolf O\nchampionship O\non O\nSunday O\nafter O\nthe O\nfinal O\n\nround O\nwas O\nabandoned O\nbecause O\nof O\ntorrential O\nrain O\n. O\n\nScores O\nafter O\nthree O\nrounds O\n( O\nBritain B-LOC\nunless O\nstated O\n) O\n: O\n\n193 O\nIan B-PER\nWoosnam I-PER\n64 O\n64 O\n65 O\n. O\n\n199 O\nThomas B-PER\nGogele I-PER\n( O\nGermany B-LOC\n) O\n67 O\n65 O\n67 O\n, O\nRobert B-PER\nKarlsson I-PER\n\n( O\nSweden B-LOC\n) O\n67 O\n62 O\n70 O\n, O\nIan B-PER\nPyman I-PER\n66 O\n64 O\n69 O\n, O\nFernando B-PER\nRoca I-PER\n\n( O\nSpain B-LOC\n) O\n66 O\n64 O\n69 O\n. O\n\n200 O\nDiego B-PER\nBorrego I-PER\n( O\nSpain B-LOC\n) O\n69 O\n63 O\n68 O\n, O\nMiguel B-PER\nAngel I-PER\nMartin I-PER\n\n( O\nSpain B-LOC\n) O\n66 O\n66 O\n68 O\n. O\n\n201 O\nStephen B-PER\nAmes I-PER\n( O\nTrinidad B-LOC\n) O\n68 O\n65 O\n68 O\n, O\nRoger B-PER\nChapman I-PER\n72 O\n62 O\n67 O\n, O\n\nPaul B-PER\nBroadhurst I-PER\n62 O\n70 O\n69 O\n, O\nStephen B-PER\nField I-PER\n66 O\n65 O\n70 O\n, O\n\nCarl B-PER\nSuneson I-PER\n( O\nSpain B-LOC\n) O\n65 O\n66 O\n70 O\n\n202 O\nGreg B-PER\nTurner I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n70 O\n67 O\n65 O\n, O\nHeinz-Peter B-PER\nThul I-PER\n\n( O\nGermany B-LOC\n) O\n70 O\n67 O\n65 O\n, O\nRonan B-PER\nRafferty I-PER\n64 O\n72 O\n66 O\n, O\nBarry B-PER\nLane I-PER\n\n68 O\n67 O\n67 O\n, O\nDavid B-PER\nCarter I-PER\n66 O\n69 O\n67 O\n, O\nMichael B-PER\nJonzon I-PER\n( O\nSweden B-LOC\n) O\n\n67 O\n67 O\n68 O\n, O\nDavid B-PER\nWilliams I-PER\n67 O\n67 O\n68 O\n\n203 O\nLee B-PER\nWestwood I-PER\n66 O\n71 O\n66 O\n, O\nGary B-PER\nEmerson I-PER\n68 O\n69 O\n66 O\n, O\nPeter B-PER\nBaker I-PER\n\n70 O\n66 O\n67 O\n, O\nDes B-PER\nSmyth I-PER\n( O\nIreland B-LOC\n) O\n66 O\n69 O\n68 O\n, O\nPaul B-PER\nLawrie I-PER\n\n66 O\n69 O\n68 O\n, O\nFrancisco B-PER\nCea I-PER\n( O\nSpain B-LOC\n) O\n68 O\n66 O\n69 O\n, O\nPedro B-PER\nLinhart I-PER\n\n( O\nSpain B-LOC\n) O\n67 O\n67 O\n69 O\n, O\nJonathan B-PER\nLomas I-PER\n67 O\n67 O\n69 O\n, O\nPaul B-PER\nEales I-PER\n\n67 O\n68 O\n68 O\n, O\nRaymond B-PER\nRussell I-PER\n63 O\n69 O\n71 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPSV B-ORG\nBEAT O\nGRONINGEN B-ORG\n4-1 O\nTO O\nPULL O\nAWAY O\nFROM O\nAJAX B-ORG\n. O\n\nAMSTERDAM B-LOC\n1996-08-25 O\n\nBelgian B-MISC\ninternational O\nLuc B-PER\nNilis I-PER\nscored O\ntwice O\non O\nSunday O\nas O\nPSV B-ORG\nEindhoven I-ORG\ncame O\nfrom O\nbehind O\nto O\nbeat O\nGroningen B-ORG\n4-1 O\nin O\nEindhoven B-LOC\n. O\n\nPSV B-ORG\nand O\nVitesse B-ORG\nArnhem I-ORG\nare O\nthe O\nonly O\nunbeaten O\nteams O\nafter O\ntwo O\nrounds O\nof O\nthe O\nDutch B-MISC\nleague O\n. O\n\nDefending O\nchampions O\nAjax B-ORG\nAmsterdam I-ORG\nwere O\ndefeated O\n2-0 O\nloss O\naway O\nto O\nHeerenveen B-ORG\non O\nSaturday O\n. O\n\nGroningen B-ORG\ntook O\nthe O\nlead O\nin O\nthe O\nseventh O\nminute O\nwhen O\nDean B-PER\nGorre I-PER\nintercepted O\na O\nback O\npass O\nfrom O\nErnest B-PER\nFaber I-PER\nto O\ngoalkeeper O\nRonald B-PER\nWaterreus I-PER\nand O\nshot O\nhome O\n. O\n\nFaber B-PER\nmade O\namends O\nin O\nthe O\n32nd O\nminute O\nwhen O\nhe O\nheaded O\nin O\na O\ncorner O\nto O\nscore O\nthe O\nequaliser O\n. O\n\nPSV B-ORG\ntook O\ncontrol O\nin O\nthe O\nsecond O\nhalf O\nbut O\ncould O\nnot O\nscore O\nuntil O\nGroningen B-ORG\nstriker O\nRomano B-PER\nSion I-PER\nwas O\nsent O\noff O\nin O\nthe O\n58th O\nminute O\n. O\n\nFive O\nminutes O\nafter O\nhis O\ndimissal O\n, O\nNilis B-PER\ngave O\nPSV B-ORG\nthe O\nlead O\nand O\nin O\nthe O\nfinal O\n15 O\nminutes O\nhe O\nadded O\nanother O\nas O\ndid O\nZeljko B-PER\nPetrovic I-PER\n. O\n\nVitesse B-ORG\nArnhem I-ORG\nupstaged O\nUtrecht B-ORG\n1-0 O\ndespite O\nending O\nthe O\nmatch O\nwith O\nonly O\nnine O\nmen O\nfollowing O\nthe O\ndismissal O\nof O\ndefenders O\nRaymond B-PER\nAtteveld I-PER\nand O\nErwin B-PER\nvan I-PER\nder I-PER\nLooi I-PER\n. O\n\nGaston B-PER\nTaument I-PER\nscored O\ntwice O\nand O\nnewly O\nsigned O\nArgentine B-MISC\nPablo B-PER\nSanchez I-PER\nonce O\nin O\nFeyenoord B-ORG\nRotterdam I-ORG\n's O\n3-0 O\nvictory O\nover O\nVolendam B-ORG\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBELGIAN B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nBRUSSELS B-LOC\n1996-08-25 O\n\nResults O\nof O\nBelgian B-MISC\nfirst O\n\ndivision O\nsoccer O\nmatches O\nat O\nthe O\nweekend O\n: O\n\nGenk B-ORG\n1 O\nClub B-ORG\nBrugge I-ORG\n1 O\n\nHarelbeke B-ORG\n3 O\nMechelen B-ORG\n3 O\n\nStandard B-ORG\nLiege I-ORG\n3 O\nMolenbeek B-ORG\n0 O\n\nAnderlecht B-ORG\n2 O\nLokeren B-ORG\n2 O\n\nCercle B-ORG\nBrugge I-ORG\n2 O\nMouscron B-ORG\n2 O\n\nAntwerp B-ORG\n1 O\nLommel B-ORG\n4 O\n\nGhent B-ORG\n3 O\nAalst B-ORG\n2 O\n\nLierse B-ORG\n4 O\nCharleroi B-ORG\n0 O\n\nSint B-ORG\nTruiden I-ORG\n3 O\nEkeren B-ORG\n1 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nGhent B-ORG\n4 O\n3 O\n1 O\n0 O\n9 O\n5 O\n10 O\n\nStandard B-ORG\nLiege I-ORG\n4 O\n3 O\n0 O\n1 O\n7 O\n3 O\n9 O\n\nClub B-ORG\nBrugge I-ORG\n4 O\n2 O\n2 O\n0 O\n10 O\n4 O\n8 O\n\nMouscron B-ORG\n4 O\n2 O\n2 O\n0 O\n7 O\n4 O\n8 O\n\nAnderlecht B-ORG\n4 O\n1 O\n3 O\n0 O\n9 O\n3 O\n6 O\n\nLierse B-ORG\n4 O\n1 O\n3 O\n0 O\n7 O\n3 O\n6 O\n\nAntwerp B-ORG\n4 O\n2 O\n0 O\n2 O\n6 O\n10 O\n6 O\n\nGenk B-ORG\n4 O\n1 O\n2 O\n1 O\n6 O\n5 O\n5 O\n\nMolenbeek B-ORG\n4 O\n1 O\n2 O\n1 O\n4 O\n5 O\n5 O\n\nHarelbeke B-ORG\n4 O\n1 O\n1 O\n2 O\n6 O\n7 O\n4 O\n\nAalst B-ORG\n4 O\n1 O\n1 O\n2 O\n5 O\n6 O\n4 O\n\nLokeren B-ORG\n4 O\n1 O\n1 O\n2 O\n4 O\n5 O\n4 O\n\nEkeren B-ORG\n4 O\n1 O\n1 O\n2 O\n6 O\n8 O\n4 O\n\nLommel B-ORG\n4 O\n1 O\n1 O\n2 O\n5 O\n10 O\n4 O\n\nMechelen B-ORG\n4 O\n0 O\n3 O\n1 O\n6 O\n7 O\n3 O\n\nCercle B-ORG\nBrugge I-ORG\n4 O\n0 O\n3 O\n1 O\n4 O\n5 O\n3 O\n\nCharleroi B-ORG\n4 O\n1 O\n0 O\n3 O\n4 O\n8 O\n3 O\n\nSint B-ORG\nTruiden I-ORG\n4 O\n1 O\n0 O\n3 O\n4 O\n11 O\n3 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nSUMMARIES O\n. O\n\nAMSTERDAM B-LOC\n1996-08-25 O\n\nSummary O\nof O\nDutch B-MISC\nfirst O\ndivision O\n\nsoccer O\nplayed O\non O\nSunday O\n: O\n\nFeyenoord B-ORG\nRotterdam I-ORG\n3 O\n( O\nSanchez B-PER\n27th O\n, O\nTaument B-PER\n44th O\n, O\n57th O\n) O\n\nVolendam B-ORG\n0 O\n. O\n\nHalftime O\n2-0 O\n. O\n\nAttendance O\nnot O\ngiven O\n. O\n\nNEC B-ORG\nNijmegen I-ORG\n0 O\nAZ B-ORG\nAlkmaar I-ORG\n0 O\n. O\n\nAttendance O\nnot O\ngiven O\n. O\n\nVitesse B-ORG\nArnhem I-ORG\n1 O\n( O\nVan B-PER\nWanrooy I-PER\n58th O\n) O\nUtrecht B-ORG\n0 O\n. O\n\nHalftime O\n0-0 O\n. O\n\nAttendance O\n7,032 O\n. O\n\nTwente B-ORG\nEnschede I-ORG\n1 O\n( O\nHoogma B-PER\n30th O\n) O\nRoda B-ORG\nJC I-ORG\nKerkrade I-ORG\n1 O\n( O\nRoelofsen B-PER\n\n28th O\n) O\n. O\n\nHalftime O\n1-1 O\n. O\n\nAttendance O\nnot O\ngiven O\n. O\n\nPSV B-ORG\nEindhoven I-ORG\n4 O\n( O\nFaber B-PER\n32nd O\n, O\nNilis B-PER\n63rd O\n79th O\n, O\nPetrovic B-PER\n78th O\n) O\n\nGroningen B-ORG\n1 O\n( O\nGorre B-PER\n7th O\n) O\n. O\n\nHalftime O\n1-1 O\n. O\n\nAttendance O\n27,500 O\n\nPlayed O\non O\nSaturday O\n: O\n\nGraafschap B-ORG\nDoetinchem I-ORG\n3 O\n( O\nIbrahim B-PER\n20th O\n63rd O\n, O\nGodee B-PER\n54th O\n) O\nRKC B-ORG\n\nWaalwijk B-ORG\n2 O\n( O\nDos B-PER\nSantos I-PER\n38th O\n, O\nVan B-PER\nArum I-PER\n73th O\npenalty O\n) O\n. O\n\nHalftime O\n\n1-1 O\n. O\n\nAttendance O\n7,000 O\n\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n0 O\nFortuna B-ORG\nSittard I-ORG\n1 O\n( O\nHamming B-PER\n65th O\n) O\n. O\n\nHalftime O\n\n0-0 O\n. O\n\nAttendance O\n7,250 O\n. O\n\nNAC B-ORG\nBreda I-ORG\n1 O\n( O\nArnold B-PER\n70th O\n) O\nSparta B-ORG\nRotterdam I-ORG\n0 O\n. O\n\nHaldtime O\n0-0 O\n. O\n\nAttendance O\n11,500 O\n. O\n\nHeerenveen B-ORG\n2 O\n( O\nWouden B-PER\n53rd O\n, O\nDahl B-PER\nTomasson I-PER\n74th O\n) O\nAjax B-ORG\nAmsterdam I-ORG\n\n0. O\nHalftime O\n0-0 O\n. O\n\nAttendance O\n13,500 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nTABLE O\n. O\n\nAMSTERDAM B-LOC\n1996-08-25 O\n\nResult O\nof O\nDutch B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatch O\nplayed O\non O\nSunday O\n: O\n\nFeyenoord B-ORG\nRotterdam I-ORG\n3 O\nVolendam B-ORG\n0 O\n\nNEC B-ORG\nNijmegen I-ORG\n0 O\nAZ B-ORG\nAlkmaar I-ORG\n0 O\n\nVitesse B-ORG\nArnhem I-ORG\n1 O\nUtrecht B-ORG\n0 O\n\nTwente B-ORG\nEnschede I-ORG\n1 O\nRoda B-ORG\nJC I-ORG\n1 O\n\nPSV B-ORG\nEindhoven I-ORG\n4 O\nGroningen B-ORG\n1 O\n\nPlayed O\non O\nSaturday O\n: O\n\nGraafschap B-ORG\nDoetinchem I-ORG\n3 O\nRKC B-ORG\nWaalwijk I-ORG\n2 O\n\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n0 O\nFortuna B-ORG\nSittard I-ORG\n1 O\n\nNAC B-ORG\nBreda I-ORG\n1 O\nSparta B-ORG\nRotterdam I-ORG\n0 O\n\nHeerenveen B-ORG\n2 O\nAjax B-ORG\nAmsterdam I-ORG\n0 O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nPSV B-ORG\nEindhoven I-ORG\n2 O\n2 O\n0 O\n0 O\n8 O\n2 O\n6 O\n\nVitesse B-ORG\nArnhem I-ORG\n2 O\n2 O\n0 O\n0 O\n3 O\n0 O\n6 O\n\nFeyenoord B-ORG\nRotterdam I-ORG\n2 O\n1 O\n1 O\n0 O\n4 O\n1 O\n4 O\n\nGraafschap B-ORG\nDoetinchem I-ORG\n2 O\n1 O\n1 O\n0 O\n4 O\n3 O\n4 O\n\nTwente B-ORG\nEnschede I-ORG\n2 O\n1 O\n1 O\n0 O\n4 O\n2 O\n4 O\n\nFortuna B-ORG\nSittard I-ORG\n2 O\n1 O\n1 O\n0 O\n1 O\n0 O\n4 O\n\nHeerenveen B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n3 O\n3 O\n\nNAC B-ORG\nBreda I-ORG\n2 O\n1 O\n0 O\n1 O\n1 O\n1 O\n3 O\n\nAjax B-ORG\nAmsterdam I-ORG\n2 O\n1 O\n0 O\n1 O\n1 O\n2 O\n3 O\n\nRoda B-ORG\nJC I-ORG\nKerkrade I-ORG\n2 O\n0 O\n2 O\n0 O\n2 O\n2 O\n2 O\n\nUtrecht B-ORG\n2 O\n0 O\n1 O\n1 O\n2 O\n3 O\n1 O\n\nRKC B-ORG\nWaalwijk I-ORG\n2 O\n0 O\n1 O\n1 O\n4 O\n5 O\n1 O\n\nSparta B-ORG\nRotterdam I-ORG\n2 O\n0 O\n1 O\n1 O\n0 O\n1 O\n1 O\n\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n2 O\n0 O\n1 O\n1 O\n0 O\n1 O\n1 O\n\nAZ B-ORG\nAlkmaar I-ORG\n2 O\n0 O\n1 O\n1 O\n0 O\n2 O\n1 O\n\nVolendam B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n4 O\n1 O\n\nGroningen B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n4 O\n1 O\n\nNEC B-ORG\nNijmegen I-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n4 O\n1 O\n\n-DOCSTART- O\n\nDUTCH B-MISC\nCAPTAIN O\nBLIND B-PER\nENDS O\nINTERNATIONAL O\nCAREER O\n. O\n\nAMSTERDAM B-LOC\n1996-08-25 O\n\nDutch B-MISC\nsoccer O\ncaptain O\nDanny B-PER\nBlind I-PER\nhas O\ndecided O\nto O\nend O\nhis O\ninternational O\ncareer O\n, O\nAjax B-ORG\nspokesman O\nDavid B-PER\nEndt I-PER\nsaid O\non O\nSunday O\n. O\n\nEndt B-PER\ntold O\nDutch B-MISC\nnews O\nagency O\nANP B-ORG\nthat O\nBlind B-PER\n, O\n35 O\n, O\nwould O\nno O\nlonger O\nbe O\navailable O\nfor O\nselection O\nfor O\nthe O\nnational O\nsquad O\n. O\n\nThe O\nAjax B-ORG\ndefender O\n, O\nwho O\nled O\nthe O\nNetherlands B-LOC\ninto O\nthe O\nquarter-finals O\nat O\nJune O\n's O\nEuropean B-MISC\nchampionship O\nfinals O\nin O\nEngland B-LOC\n, O\nhad O\ndecided O\nto O\ndevote O\nhis O\nattention O\nto O\nplaying O\nfor O\nhis O\nAmsterdam B-LOC\nclub O\n, O\nEndt B-PER\nsaid O\n. O\n\nBlind B-PER\n, O\nwho O\nplayed O\nin O\nthe O\n1990 B-MISC\nWorld I-MISC\nCup I-MISC\nand O\nthe O\n1992 B-MISC\nEuropean I-MISC\nchampionship I-MISC\n, O\nwas O\ncapped O\n42 O\ntimes O\nfor O\nthe O\nNetherlands B-LOC\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nINDIA B-LOC\nBANS O\nSIDHU B-PER\nFOR O\n50 O\nDAYS O\n. O\n\nNEW B-LOC\nDELHI I-LOC\n1996-08-25 O\n\nIndian B-MISC\nopener O\nNavjot B-PER\nSingh I-PER\nSidhu I-PER\nwas O\non O\nSunday O\ngiven O\na O\n50-day O\nban O\nfrom O\ninternational O\ncricket O\nfor O\nquitting O\nthis O\nyear O\n's O\ntour O\nof O\nEngland B-LOC\n, O\nthe O\nPress B-ORG\nTrust I-ORG\nof I-ORG\nIndia I-ORG\nsaid O\n. O\n\nThe O\nright-handed O\nbatsman O\nwill O\nhave O\nto O\nforfeit O\nhalf O\nthe O\nmoney O\nhe O\nwas O\ndue O\nto O\nearn O\nfrom O\nthe O\ntour O\n, O\nthe O\nnews O\nagency O\nsaid O\nafter O\na O\ndisciplinary O\ncommittee O\nset O\nup O\nby O\nthe O\nBoard B-ORG\nof I-ORG\nControl I-ORG\nfor I-ORG\nCricket I-ORG\nin I-ORG\nIndia I-ORG\nmet O\nat O\nMohali B-LOC\n, O\nnear O\nthe O\nnorthern O\ncity O\nof O\nChandigarh B-LOC\n. O\n\nSidhu B-PER\nabandoned O\nthe O\nIndian B-MISC\nteam O\nafter O\nthe O\nthird O\none-day O\ninternational O\nagainst O\nEngland B-LOC\nat O\nOld B-LOC\nTrafford I-LOC\nin O\nManchester B-LOC\non O\nMay O\n26 O\n, O\nbefore O\nIndia B-LOC\nbegan O\na O\nthree-test O\nseries O\n, O\nciting O\nserious O\ndifferences O\nwith O\ncaptain O\nMohammed B-PER\nAzharuddin I-PER\n. O\n\nAzharuddin B-PER\nwas O\nsacked O\nafter O\nthe O\ntour O\nand O\nreplaced O\nby O\nSachin B-PER\nTendulkar I-PER\n. O\n\nSidhu B-PER\nwas O\nnot O\nconsidered O\nfor O\nthe O\nfour-nation O\nSinger B-MISC\nCup I-MISC\nbeginning O\nin O\nSri B-LOC\nLanka I-LOC\nthis O\nmonth O\nand O\nthe O\nSahara B-MISC\nCup I-MISC\nagainst O\nPakistan B-LOC\nscheduled O\nto O\nbe O\nplayed O\nin O\nCanada B-LOC\nnext O\nmonth O\n. O\n\nSidhu B-PER\n, O\nwhose O\nban O\nends O\non O\nOctober O\n14 O\n, O\nwill O\nbe O\nfree O\nto O\nplay O\ndomestic O\ncricket O\n. O\n\nHe O\nwill O\nnot O\nbe O\nconsidered O\nfor O\na O\ntest O\nmatch O\nagainst O\nAustralia B-LOC\nstarting O\non O\nOctober O\n10 O\nin O\nNew B-LOC\nDelhi I-LOC\n, O\nthe O\nUnited B-ORG\nNews I-ORG\nof I-ORG\nIndia I-ORG\nsaid O\n. O\n\n-DOCSTART- O\n\nRUGBY B-MISC\nLEAGUE I-MISC\n- O\nAustralian B-MISC\nrugby O\nleague O\nstandings O\n. O\n\nSYDNEY B-LOC\n1996-08-26 O\n\nAustralian B-MISC\nrugby O\nleague O\npremiership O\nstandings O\nafter O\nmatches O\nplayed O\nat O\nthe O\nweekend O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\npoints O\nfor O\n, O\nagainst O\n, O\ntotal O\npoints O\n) O\n: O\n\nManly B-ORG\n21 O\n17 O\n0 O\n4 O\n501 O\n181 O\n34 O\n\nBrisbane B-ORG\n21 O\n16 O\n0 O\n5 O\n569 O\n257 O\n32 O\n\nNorth B-ORG\nSydney I-ORG\n21 O\n14 O\n2 O\n5 O\n560 O\n317 O\n30 O\n\nSydney B-ORG\nCity I-ORG\n20 O\n14 O\n1 O\n5 O\n487 O\n293 O\n29 O\n\nCronulla B-ORG\n20 O\n12 O\n2 O\n6 O\n359 O\n258 O\n26 O\n\nCanberra B-ORG\n21 O\n12 O\n1 O\n8 O\n502 O\n374 O\n25 O\n\nSt B-ORG\nGeorge I-ORG\n21 O\n12 O\n1 O\n8 O\n421 O\n344 O\n25 O\n\nNewcastle B-ORG\n21 O\n11 O\n1 O\n9 O\n416 O\n366 O\n23 O\n\nWestern B-ORG\nSuburbs I-ORG\n21 O\n11 O\n1 O\n9 O\n382 O\n426 O\n23 O\n\nAuckland B-ORG\n21 O\n11 O\n0 O\n10 O\n406 O\n389 O\n22 O\n\nSydney B-ORG\nTigers I-ORG\n21 O\n11 O\n0 O\n10 O\n309 O\n435 O\n22 O\n\nParramatta B-ORG\n21 O\n10 O\n1 O\n10 O\n388 O\n391 O\n21 O\n\nSydney B-ORG\nBulldogs I-ORG\n21 O\n10 O\n0 O\n11 O\n325 O\n356 O\n20 O\n\nIllawarra B-ORG\n21 O\n8 O\n0 O\n13 O\n395 O\n432 O\n16 O\n\nWestern B-ORG\nReds I-ORG\n21 O\n6 O\n1 O\n14 O\n297 O\n398 O\n13 O\n\nPenrith B-ORG\n21 O\n6 O\n1 O\n14 O\n339 O\n448 O\n13 O\n\nNorth B-ORG\nQueensland I-ORG\n21 O\n6 O\n0 O\n15 O\n266 O\n593 O\n12 O\n\nGold B-ORG\nCoast I-ORG\n21 O\n5 O\n1 O\n15 O\n351 O\n483 O\n11 O\n\nSouth B-ORG\nSydney I-ORG\n21 O\n5 O\n1 O\n15 O\n304 O\n586 O\n11 O\n\nSouth B-ORG\nQueensland I-ORG\n21 O\n4 O\n0 O\n17 O\n210 O\n460 O\n8 O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373-1800 O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nAll B-ORG\nBlacks I-ORG\nrelive O\ntriumph O\n. O\n\nPRETORIA B-LOC\n, O\nAug O\n25 O\n- O\nCaptain O\nSean B-PER\nFitzpatrick I-PER\nand O\nhis O\nAll B-ORG\nBlacks I-ORG\nrevisited O\nthe O\ntest O\nvenue O\ntoday O\nto O\nrelive O\nsome O\nof O\nthe O\nmagic O\nmoments O\nof O\nyesterday O\n's O\nmomentous O\nrugby O\nvictory O\nover O\nSouth B-LOC\nAfrica I-LOC\n, O\nNZPA B-ORG\nreported O\n. O\n\nMost O\nof O\nthe O\ntest O\n15 O\nwho O\nbeat O\nthe O\nSpringboks B-ORG\n33-26 O\nto O\nsecure O\nNew B-LOC\nZealand I-LOC\n's O\nfirst-ever O\nrugby O\nseries O\nin O\nSouth B-LOC\nAfrica I-LOC\nstood O\nin O\nthe O\nmiddle O\nof O\nthe O\nempty O\n50,000-seat O\nLoftus B-LOC\nVersfeld I-LOC\n. O\n\nMagnificent O\n, O\n' O\n' O\nsaid O\nFitzpatrick B-PER\n, O\nNew B-LOC\nZealand I-LOC\n's O\nmost O\ncapped O\nplayer O\nand O\nthe O\nworld O\n's O\nmost O\ncapped O\nforward O\n. O\n\nThe O\nplayers O\nrelived O\nthe O\nmoves O\nand O\ntries O\n, O\nthe O\ntackles O\nand O\nwhat O\nmight O\nhave O\nbeen O\nas O\nthe O\nemotions O\nof O\nvictory O\ncontinued O\n. O\n\nZinzan B-PER\nBrooke I-PER\n, O\nthe O\nonly O\nNo O\n8 O\nin O\ntest O\nrugby O\nto O\nhave O\nscored O\na O\ndropped O\ngoal O\nwhen O\nhe O\nkicked O\na O\nthree-pointer O\nagainst O\nEngland B-LOC\nduring O\nlast O\nyear O\n's O\nWorld B-MISC\nCup I-MISC\n, O\nadded O\na O\nsecond O\nto O\nhis O\nname O\nyesterday O\n. O\n\nI O\nwas O\nright O\nhere O\n, O\n' O\n' O\nhe O\nsaid O\nstanding O\nat O\nthe O\nspot O\nwhere O\nhe O\nhad O\nreceived O\nthe O\nball O\nfor O\nthe O\nkick O\n. O\n\nThe O\nmaul O\nwas O\nthere O\nand O\nI O\nwas O\ngoing O\nto O\ngo O\nin O\nbut O\nI O\nthought O\nI O\nshould O\nhold O\noff O\nbecause O\nwe O\nhad O\nthe O\nball O\n. O\n\nWhen O\n( O\nhalfback O\n) O\nJustin B-PER\nMarshall I-PER\ngot O\nthe O\nball O\nhe O\nwas O\ngoing O\nto O\ngo O\non O\nthe O\nopenside O\nwhere O\nJon B-PER\nPreston I-PER\nwas O\nso O\nI O\nemptied O\nmy O\nlung O\nat O\nhim O\nto O\nget O\nthe O\nball O\nthis O\nway O\n. O\n\nI O\njust O\nhit O\nthrough O\nand O\nI O\nwas O\npunching O\nthe O\nair O\nbefore O\nthe O\nball O\ngot O\nthere O\n. O\n\nIt O\ncost O\nme O\na O\nfew O\nbucks O\nat O\nthe O\nbar O\n. O\n' O\n\n' O\n\nThe O\ndecision O\nto O\nattempt O\na O\ndropped O\ngoal O\nwas O\na O\nspontaneous O\none O\n, O\nBrooke B-PER\nsaid O\n. O\n\nIt O\nwas O\njust O\nlike O\nthe O\nWorld B-MISC\nCup I-MISC\n, O\nthe O\nball O\ncame O\nand O\nthe O\nchance O\nwas O\nthere O\n. O\n' O\n\n' O\n\nCentre O\nFrank B-PER\nBunce I-PER\nsaid O\nhe O\nhad O\nnever O\nfelt O\nso O\nexhausted O\nduring O\na O\nmatch O\n. O\n\nWe O\nwere O\ngutted O\nand O\nthere O\nwas O\nnowhere O\nto O\nhide O\n, O\nthey O\njust O\nkept O\ncoming O\nat O\nyou O\n, O\n' O\n' O\nhe O\nsaid O\n. O\n\nI O\nwas O\ngone O\nin O\nthe O\nfirst O\n20 O\nminutes O\n, O\ncompletely O\nexhausted O\n, O\nbut O\nyou O\nhad O\nno O\nchoice O\n. O\n\nThere O\nwas O\njust O\nso O\nmuch O\nriding O\non O\nit O\n. O\n\nIt O\n's O\namazing O\njust O\nhow O\nbig O\nthis O\nground O\nwas O\nyesterday O\n. O\n' O\n\n' O\n\nTwo-try O\nwinger O\nJeff B-PER\nWilson I-PER\nsaid O\nhe O\nwas O\nso O\ntired O\nthat O\nhe O\nkept O\nasking O\nBunce B-PER\nwhere O\nhe O\nshould O\nbe O\nwhile O\ndefending O\n. O\n\nHe O\ntold O\nme O\nI O\n'm O\nbuggered O\ntoo O\nso O\njust O\nhang O\nin O\nthere O\n' O\n, O\n' O\n' O\nWilson B-PER\nrecalled O\n. O\n\nAbout O\n4000 O\nNew B-MISC\nZealander I-MISC\nsupporters O\nwere O\npartying O\ninto O\nthe O\nearly O\nhours O\nof O\ntoday O\nin O\nthe O\nSouth B-MISC\nAfrican I-MISC\ncapital O\n. O\n\nMessages O\nof O\ngoodwill O\ncontinued O\nto O\nroll O\ninto O\nthe O\nteam O\nhotel O\n. O\n\nAll B-ORG\nBlacks I-ORG\ncoach O\nJohn B-PER\nHart I-PER\nsaid O\nPrime O\nMinister O\nJim B-PER\nBolger I-PER\nrang O\nhim O\ntoday O\nto O\noffer O\nhis O\ncongratulations O\n. O\n\nHe O\nthanked O\nus O\non O\nbehalf O\nof O\nthe O\ncountry O\n, O\nwhich O\nis O\nreally O\nnice O\nfor O\nthe O\nteam O\n, O\nand O\nI O\nunderstand O\nwe O\nhad O\ntremendous O\nsupport O\nat O\nhome O\n. O\n' O\n\n' O\n\n-DOCSTART- O\n\nAustralian B-MISC\nRules I-MISC\n- O\nAFL B-ORG\nresults O\nand O\nstandings O\n. O\n\nMELBOURNE B-LOC\n1996-08-26 O\n\nResults O\nof O\nAustralian B-MISC\nRules I-MISC\nmatches O\nplayed O\nat O\nthe O\nweekend O\n. O\n\nPlayed O\nSunday O\n: O\n\nAdelaide B-ORG\n14.12 O\n( O\n96 O\n) O\nCollingwood B-ORG\n24 O\n. O\n\n9 O\n( O\n153 O\n) O\n\nWest B-ORG\nCoast I-ORG\n24 O\n. O\n\n7 O\n( O\n151 O\n) O\nMelbourne B-ORG\n11.12 O\n( O\n78 O\n) O\n\nRichmond B-ORG\n28.19 O\n( O\n187 O\n) O\nFitzroy B-ORG\n5 O\n. O\n\n6 O\n( O\n36 O\n) O\n\nPlayed O\nSaturday O\n: O\n\nCarlton B-ORG\n13.18 O\n( O\n96 O\n) O\nFootscray B-ORG\n9.12 O\n( O\n66 O\n) O\n\nEssendon B-ORG\n14.16 O\n( O\n100 O\n) O\nSydney B-ORG\n12.10 O\n( O\n82 O\n) O\n\nSt B-ORG\nKilda I-ORG\n9 O\n. O\n\n9 O\n( O\n63 O\n) O\nHawthorn B-ORG\n12 O\n. O\n\n8 O\n( O\n80 O\n) O\n\nBrisbane B-ORG\n10.11 O\n( O\n71 O\n) O\nFremantle B-ORG\n10.10 O\n( O\n70 O\n) O\n\nPlayed O\nFriday O\n: O\n\nNorth B-ORG\nMelbourne I-ORG\n14.12 O\n( O\n96 O\n) O\nGeelong B-ORG\n16.13 O\n( O\n109 O\n) O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\npoints O\nfor O\n, O\nagainst O\n, O\npercentage O\n, O\ntotal O\npoints O\n) O\n: O\n\nBrisbane B-ORG\n21 O\n15 O\n1 O\n5 O\n2123 O\n1631 O\n130.2 O\n62 O\n\nSydney B-ORG\n21 O\n15 O\n1 O\n5 O\n2067 O\n1687 O\n122.5 O\n62 O\n\nWest B-ORG\nCoast I-ORG\n21 O\n15 O\n0 O\n6 O\n2151 O\n1673 O\n128.6 O\n60 O\n\nNorth B-ORG\nMelbourne I-ORG\n21 O\n15 O\n0 O\n6 O\n2385 O\n1873 O\n127.3 O\n60 O\n\nCarlton B-ORG\n21 O\n14 O\n0 O\n7 O\n2009 O\n1844 O\n108.9 O\n56 O\n\nGeelong B-ORG\n21 O\n13 O\n1 O\n7 O\n2288 O\n1940 O\n117.9 O\n54 O\n\nEssendon B-ORG\n21 O\n13 O\n1 O\n7 O\n2130 O\n1947 O\n109.4 O\n54 O\n\nRichmond B-ORG\n21 O\n11 O\n0 O\n10 O\n2173 O\n1803 O\n120.5 O\n44 O\n\nHawthorn B-ORG\n21 O\n10 O\n1 O\n10 O\n1791 O\n1820 O\n98.4 O\n42 O\n\nSt B-ORG\nKilda I-ORG\n21 O\n9 O\n0 O\n12 O\n1909 O\n1958 O\n97.5 O\n36 O\n\nCollingwood B-ORG\n21 O\n8 O\n0 O\n13 O\n2103 O\n2091 O\n100.6 O\n32 O\n\nAdelaide B-ORG\n21 O\n8 O\n0 O\n13 O\n2158 O\n2183 O\n98.9 O\n32 O\n\nMelbourne B-ORG\n21 O\n7 O\n0 O\n14 O\n1642 O\n2361 O\n69.5 O\n28 O\n\nFremantle B-ORG\n21 O\n6 O\n0 O\n15 O\n1673 O\n1912 O\n87.5 O\n24 O\n\nFootscray B-ORG\n21 O\n5 O\n1 O\n15 O\n1578 O\n2060 O\n76.6 O\n22 O\n\nFitzroy B-ORG\n21 O\n1 O\n0 O\n20 O\n1381 O\n2778 O\n49.7 O\n4 O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373-1800 O\n\n-DOCSTART- O\n\nRugby O\nleague-Australian B-MISC\nrugby O\nleague O\nresults O\n. O\n\nSYDNEY B-LOC\n1996-08-26 O\n\nResults O\nof O\nAustralian B-MISC\nrugby O\nleague O\nmatches O\nplayed O\nat O\nthe O\nweekend O\n. O\n\nPlayed O\nSunday O\n: O\n\nSydney B-ORG\nBulldogs I-ORG\n17 O\nSouth B-ORG\nQueensland I-ORG\n16 O\nBrisbane B-ORG\n38 O\nGold B-ORG\nCoast I-ORG\n10 O\n\nNorth B-ORG\nSydney I-ORG\n46 O\nSouth B-ORG\nSydney I-ORG\n4 O\n\nIllawarra B-ORG\n42 O\nPenrith B-ORG\n2 O\n\nSt B-ORG\nGeorge I-ORG\n20 O\nNorth B-ORG\nQueensland I-ORG\n24 O\n\nManly B-ORG\n42 O\nWestern B-ORG\nSuburbs I-ORG\n12 O\n\nPlayed O\nSaturday O\n: O\n\nParramatta B-ORG\n14 O\nSydney B-ORG\nTigers I-ORG\n26 O\n\nNewcastle B-ORG\n24 O\nWestern B-ORG\nReds I-ORG\n20 O\n\nPlayed O\nFriday O\n: O\n\nCanberra B-ORG\n30 O\nAuckland B-ORG\n6 O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373-1800 O\n\n-DOCSTART- O\n\nSouth B-LOC\nAfrica I-LOC\nyet O\nto O\nhear O\nfrom O\napartheid O\nenforcers O\n. O\n\nAnton B-PER\nFerreira I-PER\n\nCAPE B-LOC\nTOWN I-LOC\n1996-08-25 O\n\nSouth B-LOC\nAfrica I-LOC\n's O\ntruth O\ncommission O\nbegins O\nissuing O\nsubpoenas O\nthis O\nweek O\nin O\na O\nbid O\nto O\ndig O\nbeneath O\nthe O\npolitical O\nrationales O\nand O\nfind O\nthe O\nsinister O\nfigures O\nwho O\nhave O\nthe O\nblood O\nof O\nthe O\ncountry O\n's O\nrace O\nwar O\non O\ntheir O\nhands O\n. O\n\nLeaders O\nof O\nthe O\nmajor O\nparties O\ninvolved O\n, O\nfrom O\nright-wing O\nwhites O\nto O\nradical O\nblacks O\n, O\nappeared O\nbefore O\nArchbishop O\nDesmond B-PER\nTutu I-PER\n's O\nTruth B-ORG\nand I-ORG\nReconciliation I-ORG\nCommission I-ORG\nlast O\nweek O\nto O\npaint O\nthe O\nbroad O\npicture O\nof O\ntheir O\nactions O\nfor O\nor O\nagainst O\napartheid O\n. O\n\nMost O\n, O\nincluding O\nformer O\npresident O\nF.W. B-PER\nde I-PER\nKlerk I-PER\nand O\nAfrican B-ORG\nNational I-ORG\nCongress I-ORG\nDeputy O\nPresident O\nThabo B-PER\nMbeki I-PER\n, O\noffered O\napologies O\nfor O\nany O\nmistakes O\nthey O\nhad O\nmade O\nand O\naccepted O\nbroad O\nresponsibility O\nfor O\nthe O\nactions O\nof O\ntheir O\nfoot O\nsoldiers O\n. O\n\nBut O\nnone O\nnamed O\nthose O\nguilty O\nof O\nordering O\nor O\ncarrying O\nout O\nany O\nof O\nthe O\ngross O\nviolations O\nof O\nhuman O\nrights O\nwhich O\nTutu B-PER\nis O\ninvestigating O\n. O\n\nHuman O\nrights O\nlawyer O\nBrian B-PER\nCurrin I-PER\nsaid O\nthe O\nhearings O\nlast O\nweek O\nwere O\nnot O\nintended O\nas O\na O\nform O\nof O\nconfessional O\nand O\nthat O\nthose O\nwho O\npersonally O\ncommitted O\ncrimes O\nduring O\napartheid O\nwould O\ntestify O\nonly O\nbefore O\na O\nseparate O\narm O\nof O\nthe O\ncommission O\n, O\nthe O\namnesty O\ncommittee O\n. O\n\n\" O\nI O\ndo O\nn't O\nthink O\none O\nshould O\nhave O\nexpected O\nmore O\nthan O\nwhat O\none O\ngot O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nThat O\nwas O\nnot O\nthe O\namnesty O\ncommittee O\nwhere O\nperpetrators O\nare O\nexpected O\nto O\nopen O\ntheir O\nhearts O\nand O\nsouls O\nand O\nto O\ntell O\nit O\nall O\n. O\n\" O\n\nThe O\ncommission O\n, O\nwhich O\nhas O\nthe O\npower O\nto O\ngrant O\namnesty O\nto O\nthose O\nwho O\nconfess O\nto O\nabuses O\n, O\nhas O\nbegun O\nhearing O\nthe O\ntestimony O\nfrom O\npeople O\nalready O\nin O\njail O\nfor O\ntheir O\ndeeds O\n. O\n\nBut O\nothers O\n, O\nsuch O\nas O\nself-confessed O\nsecret O\npolice O\nhit-squad O\nleader O\nDirk B-PER\nCoetzee I-PER\n, O\nhave O\nyet O\nto O\ntestify O\n. O\n\nTutu B-PER\n's O\ndeputy O\nchairman O\n, O\nAlex B-PER\nBoraine I-PER\n, O\ntold O\nreporters O\nthe O\ncommission O\nwould O\nbegin O\nissuing O\nsubpoenas O\nto O\nsuspects O\nwho O\nrefused O\nto O\nappear O\nvoluntarily O\nsome O\ntime O\nthis O\nweek O\n. O\n\nHe O\nadded O\nthat O\nformer O\nhardline O\napartheid O\npresident O\nP.W. B-PER\nBotha I-PER\ncould O\nbe O\namong O\nthose O\ncalled O\n. O\n\nBut O\nCurrin B-PER\n, O\nwho O\nis O\nadvising O\nseveral O\npeople O\nregarded O\nas O\nperpetrators O\n, O\nsaid O\nthis O\nwas O\nnot O\nthe O\nbest O\nway O\nto O\nachieve O\nthe O\ncommission O\n's O\naims O\n. O\n\n\" O\nA O\nperson O\ncan O\nbe O\nforced O\nto O\nappear O\n, O\nbut O\nthe O\nonly O\nway O\none O\nis O\ngoing O\nto O\nget O\nto O\nthe O\ntruth O\nin O\nits O\ntotality O\nis O\nif O\npeople O\nfeel O\nit O\nis O\na O\ngood O\nidea O\nto O\ngo O\nto O\nthe O\namnesty O\ncommittee O\n. O\n\nAt O\nthe O\nmoment O\nthis O\nis O\nnot O\nthe O\ncase O\n. O\n\" O\n\nHe O\ncited O\nCoetzee B-PER\n, O\nwho O\nwas O\ncharged O\nwith O\nmurder O\nafter O\nconfessing O\nin O\nmedia O\ninterviews O\nto O\ndirty O\ntricks O\n. O\n\nHis O\ntrial O\nis O\ndue O\nto O\nstart O\nin O\nDecember O\nbut O\nthe O\ntruth O\ncommission O\nintends O\nto O\ndecide O\non O\nhis O\namnesty O\napplication O\nbefore O\nthat O\n. O\n\nCurrin B-PER\nsaid O\nthe O\nlaw O\nhad O\nto O\nbe O\nchanged O\nso O\nall O\njudicial O\nprosecutions O\nwere O\nautomatically O\nsuspended O\nfor O\nthose O\nwho O\napproached O\nthe O\ntruth O\ncommission O\n. O\n\nLast O\nweek O\n's O\nsubmissions O\nto O\nthe O\ncommission O\nby O\nthe O\nANC B-ORG\n, O\nde B-PER\nKlerk I-PER\n's O\nNational B-ORG\nParty I-ORG\nand O\nthe O\nright-wing O\nFreedom B-ORG\nFront I-ORG\nof O\nGeneral O\nConstand B-PER\nViljoen I-PER\nleft O\nmany O\nSouth B-MISC\nAfricans I-MISC\nunsatisfied O\n. O\n\nBoraine B-PER\nsaid O\nthe O\npicture O\nwas O\nincomplete O\nbecause O\nofficers O\nof O\nthe O\napartheid-era O\nsecurity O\nforces O\nhad O\nyet O\nto O\nmake O\ntheir O\nscheduled O\n, O\nseparate O\nsubmission O\n, O\nbut O\none O\nblack O\ncaller O\nto O\na O\nradio O\ntalk O\nshow O\ndeclared O\n: O\n\n\" O\nThis O\nwhole O\nthing O\nis O\nutterly O\nuseless O\n, O\nit O\ndoes O\nn't O\nhelp O\nus O\nat O\nall O\n. O\n\nWhat O\nthe O\npeople O\nexpect O\nis O\nto O\nhave O\nhouses O\n, O\nto O\nhave O\njobs O\n. O\n\" O\n\nPolitical O\nscientist O\nJannie B-PER\nGagiano I-PER\nsaid O\nhe O\ndoubted O\nthat O\nthe O\nNational B-ORG\nParty I-ORG\n, O\nwhich O\nimplemented O\napartheid O\nin O\n1948 O\nand O\nbegan O\ndismantling O\nit O\nin O\n1990 O\n, O\nfelt O\nit O\ncarried O\na O\nburden O\nof O\nguilt O\nand O\nneeded O\nto O\nbe O\nexculpated O\nthrough O\nthe O\ncommission O\n. O\n\n\" O\nTherefore O\nI O\nhave O\nsome O\ndoubts O\nabout O\nachieving O\nsome O\nform O\nof O\nreconciliation O\n. O\n\nOne O\nhas O\nto O\nfeel O\na O\nbit O\nguilty O\nto O\nfeel O\nthe O\nneed O\nfor O\nreconciling O\nyourself O\nto O\na O\nhistorical O\nadversary O\n, O\n\" O\nhe O\nsaid O\n. O\n\nProfessor O\nTom B-PER\nLodge I-PER\nof O\nthe O\nUniversity B-ORG\nof I-ORG\nthe I-ORG\nWitwatersrand I-ORG\ndemurred O\n, O\nsaying O\n: O\n\n\" O\nIn O\nthe O\nirritation O\n, O\nin O\nthe O\njokes O\n, O\nin O\nthe O\nanger O\nthat O\nwhite O\nSouth B-MISC\nAfricans I-MISC\nexpress O\nabout O\nthe O\ncommission O\n, O\nI O\nthink O\nthere O\n's O\na O\nmoral O\nuneasiness O\n, O\nand O\nI O\nthink O\nthat O\n's O\nhealthy O\n. O\n\nResponsibility O\nis O\npercolating O\ndownwards O\n. O\n\" O\n\n-DOCSTART- O\n\nMoslem B-MISC\nrefugees O\nseek O\nto O\nvote O\nin O\nSerb-held B-MISC\ntown O\n. O\n\nSamir B-PER\nArnaut I-PER\n\nMATUZICI B-LOC\n, O\nBosnia B-LOC\n1996-08-25 O\n\nThousands O\nof O\nMoslem B-MISC\nrefugees O\ndenounced O\nBosnia B-LOC\n's O\nelections O\nas O\na O\nfarce O\non O\nSunday O\nbecause O\nSerb B-MISC\nincomers O\nwould O\nbe O\nable O\nto O\nvote O\nin O\ntheir O\nold O\nhome O\ntown O\n, O\ncementing O\npartition O\nof O\nthe O\ncountry O\n. O\n\nThey O\nsaid O\nthey O\nwere O\nready O\nto O\nforce O\ntheir O\nway O\nback O\nacross O\npost-war O\nethnic O\nlines O\nto O\nSerb-held B-MISC\nDoboj B-LOC\n, O\none O\nof O\nseveral O\ntowns O\nwhere O\nNATO B-ORG\ntroops O\nfear O\nviolence O\ninvolving O\nrefugees O\ndetermined O\nto O\nvote O\nwhere O\nthey O\nonce O\nlived O\n. O\n\nThe O\nrefugees O\n, O\nrallying O\nin O\nMatuzici B-LOC\non O\ngovernment O\nterritory O\ntwo O\nkm O\nfrom O\nDoboj B-LOC\nin O\nnortheast O\nBosnia B-LOC\n, O\nwaved O\nbanners O\ncalling O\nthe O\npolls O\na O\nfarce O\nstaged O\nby O\nthe O\nUnited B-ORG\nNations I-ORG\nand O\nthe O\nEuropean B-ORG\nUnion I-ORG\n. O\n\" O\n\nWe O\ndemand O\nto O\nvote O\nin O\nDoboj B-LOC\n, O\n\" O\nother O\nbanners O\nsaid O\n. O\n\nBosnia B-LOC\n's O\nMoslem-led B-MISC\ncentral O\ngovernment O\nand O\nmany O\ndisplaced O\nMoslems B-MISC\nare O\nangered O\nby O\na O\nkey O\nprovision O\nof O\nthe O\nWestern-organised B-MISC\nSeptember O\n14 O\nelections O\nallowing O\npeople O\nto O\nvote O\nin O\npost-war O\n\" O\nnew O\nplaces O\nof O\nresidence O\n. O\n\" O\n\nAs O\na O\nresult O\n, O\nseparatist O\nSerb B-MISC\nauthorities O\nhave O\npacked O\nformer O\nMoslem B-MISC\nmajority O\ntowns O\nwith O\nrefugees O\nof O\ntheir O\nown O\nor O\nregistered O\nother O\nSerbs B-MISC\nto O\nvote O\nthere O\n. O\n\nCritics O\nsay O\nthat O\nwhat O\nwas O\nbilled O\nas O\nan O\nelectoral O\nprocess O\nto O\nreintegrate O\nBosnia B-LOC\nas O\na O\nsingle O\n, O\nmulti-ethnic O\nstate O\nis O\nshaping O\nup O\nas O\na O\nreferendum O\non O\npartition O\n, O\nde O\nfacto O\nor O\nde O\njure O\n. O\n\n\" O\nOnly O\nour O\nphysical O\npresence O\nin O\nDoboj B-LOC\nwill O\nmean O\nthat O\nthe O\nDayton B-LOC\npeace O\ntreaty O\nhas O\ntruly O\nbeen O\nimplemented O\n, O\n\" O\nEdhem B-PER\nEfendija I-PER\nCamdzic I-PER\n, O\nDoboj B-LOC\n's O\nIslamic B-MISC\nimam-in-exile O\n, O\ntold O\nthe O\nrefugees O\n. O\n\n\" O\nThe O\nmain O\npoint O\nof O\nthis O\nrally O\nis O\nto O\nhighlight O\nto O\nthe O\nworld O\npowers O\nwhat O\nmisfortune O\nthey O\nbrought O\nupon O\nus O\n, O\n\" O\nsaid O\nReuf B-PER\nMehemdagic I-PER\n, O\nhead O\nof O\nDoboj B-LOC\nmunicipality-in-exile O\n. O\n\n\" O\nEleven O\nthousand O\nSerbs B-MISC\nwho O\ncame O\nfrom O\nelsewhere O\nto O\nDoboj B-LOC\nwill O\nvote O\nthere O\n. O\n\nHow O\ncan O\nwe O\nthen O\nexpect O\nthe O\nreintegration O\nof O\nBosnia B-LOC\n? O\n\nBut O\nno O\none O\nwill O\nstop O\nus O\nfrom O\nreturning O\nto O\nour O\nhomes O\n. O\n\" O\n\nMirhunisa B-PER\nKomarica I-PER\n, O\na O\ngovernment O\nrefugee O\nofficial O\n, O\nsaid O\n: O\n\" O\nWe O\nwant O\nto O\nvote O\nwhere O\nwe O\nwere O\nthrown O\nout O\nfrom O\n. O\n\nThis O\nis O\na O\nprotest O\nof O\nwarning O\nand O\nthe O\nnext O\nstep O\nis O\nentering O\nour O\ntown O\nusing O\nall O\nmeans O\npossible O\n, O\nso O\nlet O\nthem O\nshoot O\n. O\n\" O\n\nBosnian B-MISC\nVice O\nPresident O\nEjup B-PER\nGanic I-PER\n, O\na O\nMoslem B-MISC\n, O\ntold O\nthe O\nrefugees O\n: O\n\" O\nWe O\nhave O\na O\nmessage O\nfor O\nthe O\nSerbs B-MISC\nwho O\nare O\nnow O\nin O\nour O\nhomes O\nnot O\nto O\nplan O\nthe O\nfuture O\nof O\ntheir O\nchildren O\nthere O\nbecause O\nthere O\nwill O\nbe O\nno O\ngood O\nfortune O\nin O\nthat O\n. O\n\" O\n\nTo O\nloud O\napplause O\n, O\nhe O\nadded O\n: O\n\" O\nWe O\nwill O\nenter O\nDoboj B-LOC\n, O\nuntie O\nthe O\nDoboj B-LOC\nknot O\nand O\nensure O\nfree O\nmovement O\nfor O\nall O\n. O\n\nWe O\nhave O\nto O\nenter O\nDoboj B-LOC\nto O\nfree O\nthe O\nSerbs B-MISC\nfrom O\ntheir O\nown O\n( O\nseparatist O\n) O\npolitics O\n. O\n\" O\n\nThe O\nDayton B-LOC\npeace O\naccords O\nguaranteed O\nrefugees O\nthe O\nright O\nto O\nreturn O\nto O\ntheir O\nhomes O\nand O\nensured O\nfreedom O\nof O\nmovement O\nacross O\nethnic O\nlines O\n. O\n\nBut O\nlocal O\npolice O\n, O\ncontrolled O\nby O\nnationalist O\nparties O\nin O\nMoslem B-MISC\n, O\nSerb B-MISC\nand O\nCroat B-MISC\nsectors O\nof O\nBosnia B-LOC\n, O\nand O\ncivilian O\nmobs O\nhave O\nturned O\nceasefire O\nlines O\ninto O\nvirtually O\nimpassable O\nborders O\n. O\n\nThe O\nmajority O\nof O\nrefugees O\nfrom O\nBosnia B-LOC\n's O\n1992-95 O\nwar O\nare O\nMoslems B-MISC\nfrom O\nthe O\nSerb-controlled B-MISC\nnorth O\nand O\neast O\n. O\n\nNATO-led B-MISC\npeace O\ntroops O\nbeefed O\nup O\ntheir O\npresence O\nin O\nthe O\nDoboj B-LOC\narea O\non O\nSunday O\nto O\ndeter O\nany O\nsudden O\nemotional O\nattempt O\nby O\nthe O\nrefugees O\nto O\ncross O\nthe O\nInter-Entity B-LOC\nBoundary I-LOC\nLine I-LOC\ninto O\nDoboj B-LOC\n. O\n\nBut O\nthe O\ncrowd O\ndispersed O\nwithout O\nincident O\n. O\n\nMoslems B-MISC\nand O\nSerbs B-MISC\nhave O\nscuffled O\nseveral O\ntimes O\nalong O\nthe O\nline O\nin O\nthe O\npast O\nwhen O\nMoslem B-MISC\nrefugees O\ntried O\nto O\nsurge O\ninto O\nthe O\ntown O\n. O\n\n-DOCSTART- O\n\nEight O\nkilled O\nin O\nMoscow B-LOC\ncasino O\nblaze O\n. O\n\nMOSCOW B-LOC\n1996-08-25 O\n\nEight O\npeople O\ndied O\non O\nSunday O\nin O\na O\nblaze O\nat O\na O\nMoscow B-LOC\ncasino O\nwhich O\nthe O\nfire O\nservice O\nsaid O\nmight O\nhave O\nbeen O\nstarted O\ndeliberately O\n, O\nInterfax B-ORG\nnews O\nagency O\nsaid O\n. O\n\nThe O\nnumber O\nof O\ncasinos O\nhas O\nsoared O\nin O\nMoscow B-LOC\nsince O\nthe O\ncollapse O\nof O\ncommunism O\n. O\n\nThe O\nmayor O\nhas O\nsaid O\nhe O\nwants O\nto O\ncut O\ntheir O\nnumber O\nto O\nfive O\nas O\npart O\nof O\na O\nwar O\nagainst O\norganised O\ncrime O\n. O\n\nPresident O\nBoris B-PER\nYeltsin I-PER\nsigned O\na O\ndecree O\non O\nfighting O\ncrime O\nin O\nJuly O\nand O\nhanded O\nwide-ranging O\npowers O\nto O\nsecurity O\nchief O\nAlexander B-PER\nLebed I-PER\n, O\ncurrently O\nengaged O\nin O\nmaking O\npeace O\nin O\nbreakaway O\nChechnya B-LOC\n. O\n\n-DOCSTART- O\n\nRussian B-MISC\ntroops O\nstart O\npullout O\n, O\nbut O\nnot O\nin O\nGrozny B-LOC\n. O\n\nSHATOI B-LOC\n, O\nRussia B-LOC\n1996-08-25 O\n\nRussian B-MISC\ntroops O\nbegan O\nto O\npull O\nout O\nfrom O\nsouthern O\nChechnya B-LOC\non O\nSunday O\nunder O\na O\nceasefire O\nagreement O\nbetween O\nRussian B-MISC\nsecurity O\nchief O\nAlexander B-PER\nLebed I-PER\nand O\nrebel O\nleaders O\n. O\n\nBut O\nin O\nthe O\ncapital O\nGrozny B-LOC\n, O\nthe O\ncommander O\nof O\nRussian B-MISC\nInterior O\nMinistry O\nforces O\nin O\nChechnya B-LOC\n, O\nGeneral O\nAnatoly B-PER\nShkirko I-PER\n, O\ntold O\nInterfax B-ORG\nnews O\nagency O\nhe O\nwas O\ndelaying O\na O\npullout O\nof O\ntroops O\nthere O\nafter O\na O\ngroup O\nof O\nChechens B-MISC\ndisarmed O\nan O\narmoured O\ncolumn O\n. O\n\nReuters B-ORG\ncameraman O\nLiutauras B-PER\nStremaitis I-PER\nsaid O\na O\ncolumn O\nof O\naround O\n40 O\nvehicles O\n, O\nincluding O\ntanks O\n, O\narmoured O\npersonnel O\ncarriers O\n, O\nartillery O\ncannons O\nand O\nlorries O\n, O\nescorted O\nby O\nChechen B-MISC\nrebels O\n, O\npulled O\nout O\nof O\nthe O\nvillage O\nof O\nShatoi B-LOC\ntowards O\nthe O\nborder O\n, O\naround O\n50 O\nkm O\n( O\n31 O\nmiles O\n) O\nto O\nthe O\nnorth O\n. O\n\nIn O\nGrozny B-LOC\n, O\nShkirko B-PER\ntold O\nInterfax B-ORG\nhe O\nwas O\nsuspending O\nthe O\npullout O\nof O\ntroops O\nfrom O\nthe O\ncapital O\nuntil O\nweapons O\nseized O\nby O\nthe O\nChechens B-MISC\nwere O\nreturned O\n. O\n\nChechen B-MISC\nrebel O\nspokesman O\nMovladi B-PER\nUdugov I-PER\nconfirmed O\nthe O\nweapons O\nhad O\nbeen O\nseized O\nbut O\nthat O\nit O\nwas O\na O\nmaverick O\ngroup O\nof O\nChechens B-MISC\n. O\n\nHe O\nsaid O\nlater O\nthat O\nthe O\nrebels O\nhad O\nhanded O\nthem O\nover O\n. O\n\nThe O\npullout O\nof O\nthe O\nRussian B-MISC\ntroops O\nis O\na O\nkey O\nelement O\nof O\nthe O\npeace O\nplan O\nbrokered O\nby O\nLebed B-PER\n, O\nwhich O\naims O\nto O\nend O\nthe O\n20-month O\nChechnya B-LOC\nconflict O\n. O\n\n-DOCSTART- O\n\nLeftist O\nMexican B-MISC\narmed O\ngroup O\nsays O\ntroops O\nin O\ncapital O\n. O\n\nMEXICO B-LOC\nCITY I-LOC\n1996-08-25 O\n\nThe O\nleftist O\nPopular B-ORG\nRevolutionary I-ORG\nArmy I-ORG\n( O\nEPR B-ORG\n) O\nin O\na O\npublished O\nreport O\non O\nSunday O\nsaid O\nit O\noperated O\nthroughout O\nMexico B-LOC\n, O\nincluding O\nthe O\ncapital O\n, O\nand O\ndenied O\ngovernment O\nassertions O\nit O\nwas O\nisolated O\nto O\none O\nstate O\n. O\n\nCommanders O\n\" O\nVicente B-PER\n\" O\nand O\n\" O\nOscar B-PER\n\" O\n, O\nguarded O\nby O\na O\ndozen O\nEPR B-ORG\ngunmen O\n, O\nsaid O\nin O\nan O\ninterview O\nwith O\nLa B-ORG\nJornada I-ORG\noutside O\nMexico B-LOC\nCity I-LOC\nthat O\nthe O\narmed O\ngroup O\nwas O\ncommitted O\nto O\noverthrowing O\nthe O\ngovernment O\n. O\n\n\" O\nThey O\n( O\ngovernment O\nofficials O\n) O\nwant O\nto O\npresent O\nus O\nbefore O\npublic O\nopinion O\nas O\na O\nlocal O\nproblem O\n, O\nas O\njust O\nbeing O\nfrom O\nGuerrero B-LOC\nand O\nas O\nirrational O\nradicals O\n, O\n\" O\nCommander O\nOscar B-PER\ntold O\nLa B-ORG\nJornada I-ORG\n. O\n\nThey O\nsaid O\nthe O\nERP B-ORG\n, O\nwhose O\nfighters O\nfirst O\nappeared O\nwearing O\nmilitary O\nfatigues O\nand O\nbrandishing O\nassault O\nrifles O\nin O\nthe O\nsouthwestern O\nstate O\nof O\nGuerrero B-LOC\non O\nJune O\n28 O\n, O\nhad O\na O\n23,000-strong O\nmembership O\n, O\nbut O\nthis O\ncould O\nnot O\nbe O\nconfirmed O\nindependently O\n. O\n\nLa B-ORG\nJornada I-ORG\nalso O\nreported O\non O\nSunday O\nthat O\nthe O\nMexican B-ORG\nArmy I-ORG\nhas O\ndiscovered O\na O\n37-page O\n, O\nEPR B-ORG\nmanual O\ndetailing O\nguerrilla O\ntactics O\nand O\nstrategies O\n. O\n\nIt O\nquoted O\nthe O\nmanual O\nas O\nsaying O\n: O\n\" O\nThe O\nobjective O\nof O\nthe O\nBasic O\nCourse O\non O\nWar O\nis O\nto O\nprovide O\nfor O\ncombatants O\nof O\nthe O\nEPR B-ORG\nbasic O\nmilitary O\nknowledge O\nfor O\nthe O\narmed O\nconflict O\nagainst O\nthe O\npolice O\nand O\nmilitary O\napparatus O\nof O\nthe O\nbourgeoisie O\n. O\n\" O\n\nIt O\nwas O\nthe O\nsecond O\ntime O\narmed O\n\" O\ncommanders O\n\" O\nof O\nthe O\nEPR B-ORG\nhave O\ngranted O\ninterviews O\noutside O\nGuerrero B-LOC\nstate O\n, O\nan O\nextremely O\npoor O\nand O\nvolatile O\nregion O\nwhere O\nleftist O\nprotesters O\noften O\nhave O\nclashed O\nviolently O\nwith O\nauthorities O\n. O\n\nUnlike O\nthe O\nbetter O\nknown O\nand O\nunrelated O\nZapatista B-ORG\nrebels O\nin O\nsoutheastern O\nChiapas B-LOC\nstate O\n, O\nthe O\nEPR B-ORG\nhas O\nnever O\ntaken O\non O\nthe O\narmy O\nin O\ndirect O\ncombat O\n, O\naccording O\nto O\nofficial O\nreports O\n. O\n\nThere O\nhave O\nonly O\nbeen O\na O\nfew O\nskirmishes O\nin O\nGuerrero B-LOC\nin O\nwhich O\na O\nhandful O\nof O\npolice O\n, O\nsoldiers O\nand O\ncivilians O\nhave O\nbeen O\nkilled O\nor O\ninjured O\n. O\n\n-DOCSTART- O\n\nTen O\npeople O\ngunned O\ndown O\nin O\nnorthwest O\nColombia B-LOC\n. O\n\nBOGOTA B-LOC\n, O\nColombia B-LOC\n1996-08-25 O\n\nUnidentified O\ngunmen O\ndragged O\n10 O\nmen O\nout O\not O\ntheir O\nhomes O\nin O\na O\nrural O\narea O\nof O\nColombia B-LOC\n's O\nnorthwest O\nprovince O\nof O\nAntioquia B-LOC\nand O\nshot O\nthem O\nto O\ndeath O\n, O\nauthorities O\nsaid O\non O\nSunday O\n. O\n\nPolice O\nsaid O\nthe O\nkillings O\noccurred O\non O\nSaturday O\nmorning O\nin O\nthe O\nmunicipality O\nof O\nAnza B-LOC\nbut O\nnews O\nof O\nthe O\nmassacre O\nonly O\nreached O\nthe O\nprovincial O\ncapital O\nof O\nMedellin B-LOC\nearly O\non O\nSunday O\n. O\n\nAnza B-LOC\nis O\nonly O\n20 O\nmiles O\n( O\n30 O\nkm O\n) O\nwest O\nof O\nMedellin B-LOC\n, O\nbut O\nthere O\nare O\nno O\nroads O\nlinking O\nit O\ndirectly O\nto O\nthe O\ncity O\n. O\n\nPolice O\ninitially O\nsaid O\nleftist O\nRevolutionary B-ORG\nArmed I-ORG\nForces I-ORG\nof I-ORG\nColombia I-ORG\n( O\nFARC B-ORG\n) O\nrebels O\nwere O\nprime O\nsuspects O\nin O\nthe O\nkillings O\n. O\n\nBut O\ngunmen O\nof O\nthe O\nleft O\nand O\nright O\nhave O\nkilled O\nwith O\nimpunity O\nacross O\nAntioquia B-LOC\nfor O\nyears O\n, O\nand O\nthere O\nwere O\nunconfirmed O\nreports O\nthat O\nthe O\nlatest O\nbloodshed O\nwas O\nthe O\nwork O\nof O\na O\nright-wing O\nparamilitary O\ngroup O\n. O\n\n-DOCSTART- O\n\nPort O\nof O\nTauranaga B-LOC\nyear O\nprofit O\nclimbs O\n. O\n\nWELLINGTON B-LOC\n1996-08-26 O\n\nYear O\nto O\nJune O\n30 O\n. O\n\n( O\nmillion O\nNZ$ B-MISC\nunless O\nstated O\n) O\n\nNet O\nprofit O\n9.050 O\nvs O\n6.03 O\n\n-DOCSTART- O\n\nTwo O\nThai B-MISC\nborder O\npolice O\nwounded O\nby O\nBurma B-LOC\ngunmen O\n. O\n\nMAE B-LOC\nSOT I-LOC\n, O\nThailand B-LOC\n1996-08-25 O\n\nTwo O\nThai B-MISC\nborder O\npolicemen O\nwere O\nseriously O\nwounded O\non O\nSunday O\nwhen O\nmembers O\nof O\na O\nBurmese B-MISC\nrebel O\nsplinter O\nfaction O\nambushed O\ntheir O\npatrol O\nin O\nnorthwest O\nThailand B-LOC\n, O\nsecurity O\nofficers O\nsaid O\n. O\n\nThe O\ntwo O\nwere O\nwounded O\nin O\nthe O\nearly O\nhours O\nof O\nSunday O\nwhen O\nsome O\n30 O\nmembers O\nof O\nthe O\nDemocratic B-ORG\nKaren I-ORG\nBuddhist I-ORG\nArmy I-ORG\n( O\nDKBA B-ORG\n) O\nambushed O\ntheir O\npatrol O\non O\nthe O\nThai B-MISC\nside O\nof O\nthe O\nborder O\nwith O\nBurma B-LOC\n, O\nto O\nthe O\nnorth O\nof O\nthe O\ntown O\nof O\nMae B-LOC\nSot I-LOC\n. O\n\nThe O\nThai B-MISC\narmy O\ncommander O\nin O\nthe O\narea O\n, O\nCol O\nSuvit B-PER\nMaenmuan I-PER\n, O\ntold O\nreporters O\nthe O\nDKBA B-ORG\n, O\nwhich O\nis O\nallied O\nwith O\nthe O\nRangoon B-LOC\nmilitary O\ngovernment O\nand O\nbased O\nin O\nsoutheast O\nBurma B-LOC\n, O\nhad O\nrecently O\nstepped O\nup O\ncross-border O\ninfiltration O\n. O\n\nSuvit B-PER\nsaid O\nthe O\nmotive O\nfor O\ntheir O\nintrusions O\nwas O\nnot O\nclear O\nbut O\nhe O\nhad O\nordered O\nreinforcements O\nto O\nbeef O\nup O\nsecurity O\nalong O\nthe O\nporous O\nfrontier O\n. O\n\nThe O\nDKBA B-ORG\nwas O\nformed O\nin O\nlate O\n1994 O\nby O\nhundreds O\nof O\nguerrillas O\nwho O\nsplit O\nfrom O\nthe O\nanti-Rangoon B-MISC\nKaren B-ORG\nNational I-ORG\nUnion I-ORG\n( O\nKNU B-ORG\n) O\nand O\nallied O\nthemselves O\nwith O\nBurmese B-MISC\ngovernment O\narmy O\n, O\ntheir O\nformer O\nenemies O\n. O\n\nDKBA B-ORG\nmembers O\nhave O\nsince O\nlaunched O\nintermittent O\ncross-border O\nattacks O\non O\nKaren B-MISC\nrefugee O\ncamps O\nin O\nThailand B-LOC\n, O\nwhere O\nthe O\nmajority O\nof O\ninhabitants O\nare O\nKNU B-ORG\nsupporters O\n, O\nand O\non O\nThai B-MISC\nvillages O\nand O\npolice O\nposts O\nnear O\nthe O\nborder O\n. O\n\nBangkok B-LOC\nhas O\ncomplained O\nto O\nRangoon B-LOC\nabout O\nthe O\nraids O\nbut O\nBurmese B-MISC\nmilitary O\nauthorities O\nsay O\nthey O\nhave O\nno O\ncontol O\nover O\nthe O\nfaction O\n. O\n\nThai B-MISC\narmy O\ncommanders O\nreject O\nthe O\nexplanation O\n, O\nsaying O\nthey O\nhave O\nevidence O\nthe O\nBurmese B-MISC\narmy O\nsupplies O\nand O\ndirects O\nthe O\nrenegade O\nethnic O\nminority O\nsplinter O\nfaction O\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nF-14 B-MISC\ncatches O\nfire O\nwhile O\nlanding O\nin O\nIsrael B-LOC\n. O\n\nJERUSALEM B-LOC\n1996-08-25 O\n\nA O\nU.S. B-LOC\nfighter O\nplane O\nblew O\na O\ntyre O\nand O\ncaught O\nfire O\nwhile O\nlanding O\non O\nSunday O\nat O\nIsrael B-LOC\n's O\nBen B-LOC\nGurion I-LOC\nairport O\n, O\nan O\nairport O\nspokesman O\nsaid O\n. O\n\n\" O\nA O\nU.S. B-LOC\nF-14 B-MISC\nmilitary O\nplane O\nwhile O\nlanding O\nat O\nBen B-LOC\nGurion I-LOC\nairport O\nblew O\na O\nwheel O\nand O\na O\nfire O\nbroke O\nout O\n, O\n\" O\nsaid O\nspokesman O\nYehiel B-PER\nAmitai I-PER\n, O\nadding O\nthat O\nthe O\ntwo O\npilots O\non O\nboard O\nwere O\nnot O\ninjured O\n. O\n\n\" O\nAirport O\nofficials O\ndeclared O\nan O\nemergency O\nsituation O\nat O\nthe O\nhighest O\nlevel O\nand O\nthe O\nfire O\nbrigade O\nput O\nout O\nthe O\nflames O\nwhile O\nthe O\nplane O\nwas O\nlanding O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nEgypt B-LOC\nhopes O\njars O\nwill O\nreveal O\nsecrets O\nof O\nmummies O\n. O\n\nCAIRO B-LOC\n1996-08-25 O\n\nArchaeologists O\nin O\nEgypt B-LOC\nhave O\nfound O\npots O\nused O\nby O\nancient O\nEgyptians B-MISC\nin O\nburial O\nrites O\nthat O\nthey O\nsay O\nmay O\nreveal O\nthe O\nsecrets O\nof O\nmummification O\n. O\n\nMohammed B-PER\nSaleh I-PER\n, O\ndirector O\nof O\nthe O\nEgyptian B-MISC\nMuseum O\n, O\ntold O\nReuters B-ORG\ntelevision O\na O\nU.S. B-LOC\nteam O\nfound O\nthe O\npots O\n, O\nsome O\nof O\nwhich O\ncontain O\nhuman O\nintestines O\n, O\nin O\na O\ntomb O\nbuilt O\ninto O\nthe O\nrocks O\nwhile O\ndigging O\nin O\nDahshour B-LOC\n, O\na O\nvillage O\n40 O\nkm O\n( O\n25 O\nmiles O\n) O\nsouth O\nof O\nCairo B-LOC\n. O\n\nDahshour B-LOC\nis O\nthe O\nsite O\nof O\nEgypt B-LOC\n's O\nsecond O\nlargest O\npyramid O\n, O\nbuilt O\nfor O\nthe O\npharaoh O\nSeneferu B-PER\nmore O\nthan O\n4,500 O\nyears O\nago O\n. O\n\nSaleh B-PER\nsaid O\nthe O\nteam O\n-- O\nfrom O\nNew B-LOC\nYork I-LOC\n's O\nMetropolitan B-LOC\nMuseum I-LOC\n-- O\nfound O\nfour O\nCanopic B-MISC\njars O\nand O\ntwo O\nunguent O\njars O\nin O\nthe O\ntomb O\n, O\nwhich O\nbelongs O\nto O\nan O\nunidentifed O\nperson O\nwho O\nlived O\nduring O\nthe O\n12th B-MISC\nDynasty I-MISC\n( O\n1991-1786 O\nBC B-MISC\n) O\nin O\nthe O\nMiddle B-LOC\nKingdom I-LOC\n. O\n\n\" O\nThis O\nfinding O\nis O\nimportant O\nbecause O\none O\nof O\nthe O\njars O\nstill O\ncontains O\nsubstances O\nand O\nmaterials O\nused O\nin O\nthe O\nconservation O\nof O\nmummies O\nand O\nthe O\nconservation O\nof O\nthe O\nintestines O\nand O\nall O\nthe O\nthings O\nwhich O\nwere O\nin O\nthe O\ncavity O\nof O\na O\nperson O\nwe O\nhave O\nnot O\nidentified O\nyet O\n, O\n\" O\nSaleh B-PER\nsaid O\n. O\n\n\" O\nWe O\nhope O\nthat O\nthe O\nanalysis O\nof O\nsuch O\nsubstances O\nand O\nliquids O\nwill O\nreveal O\nsome O\nsecrets O\nof O\nthe O\nmummification O\nprocess O\nand O\nmaterials O\nused O\nin O\nthis O\nprocess O\n, O\n\" O\nhe O\nadded O\n. O\n\n-DOCSTART- O\n\nSaudi B-LOC\nArabia I-LOC\nexecutes O\nPakistani B-MISC\nman O\n. O\n\nDUBAI B-LOC\n1996-08-25 O\n\nSaudi B-LOC\nArabia I-LOC\nexecuted O\non O\nSunday O\na O\nPakistani B-MISC\nman O\naccused O\nof O\nbelonging O\nto O\nan O\narmed O\ngang O\nof O\nrobbers O\n, O\nSaudi B-MISC\ntelevision O\nreported O\n. O\n\nIt O\nquoted O\nan O\nInterior B-ORG\nMinistry I-ORG\nstatement O\nas O\nsaying O\nShabir B-PER\nAhmad I-PER\nMuhammad I-PER\nJalil I-PER\nwas O\nexecuted O\nin O\nMecca B-LOC\n. O\n\nHe O\nwas O\nthe O\n26th O\nperson O\nexecuted O\nthis O\nyear O\nin O\nthe O\nkingdom O\n. O\n\nSaudi B-LOC\nArabia I-LOC\nbeheads O\nconvicted O\ndrug O\nsmugglers O\n, O\nrapists O\n, O\nmurderers O\nand O\nother O\ncriminals O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nJordan B-LOC\n- O\nAug O\n25 O\n. O\n\nAMMAN B-LOC\n1996-08-25 O\n\nThese O\nare O\nsome O\nof O\nthe O\nleading O\nstories O\nin O\nthe O\nJordanian B-MISC\npress O\non O\nSunday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nJORDAN B-ORG\nTIMES I-ORG\n\n- O\nKing O\n: O\nJordan B-LOC\nis O\nentering O\na O\nnew O\nera O\n. O\n\nNo O\ngoing O\nback O\non O\ndemocracy O\n; O\nattempts O\nto O\ntamper O\nwith O\nsecurity O\nand O\nstability O\nwill O\nnot O\nbe O\ntolerated O\n. O\n\nInformation O\nMinister O\nMarwan B-PER\nMuasher I-PER\nsays O\nthere O\nis O\nevidence O\nthat O\n\" O\nsome O\nofficial O\nparties O\nin O\nIraq B-LOC\n\" O\nwere O\nbehind O\nthe O\ndisturbances O\nin O\nthe O\nsouth O\n. O\n\n- O\nKing O\nto O\nvisit O\nBahrain B-LOC\nsoon O\n. O\n\n- O\nGovernment O\nasks O\nsenior O\nIraqi B-MISC\n\" O\ndiplomat O\n\" O\nto O\nleave O\n, O\nreviews O\nstatus O\nof O\nothers O\n. O\n\n- O\nJapanese B-MISC\nforeign O\nminister O\narrives O\nfor O\ntalks O\non O\npeace O\nprocess O\n, O\nbilateral O\nties O\n. O\n\nAL B-ORG\nRAI I-ORG\n\n- O\nPrime O\nMinister O\nAbdul-Karim B-PER\nal-Kabariti I-PER\nsays O\ngovernment O\ncommited O\nto O\nlifting O\nceiling O\nof O\ndemocracy O\n. O\n\n- O\nSaudi B-MISC\nPrince O\nSultan O\ntelephones O\nprime O\nminister O\n. O\n\n- O\nJordan B-LOC\nreleases O\n32 O\nfrom O\nsouthern O\ntown O\nof O\nKarak B-LOC\n. O\n\n- O\nJordan B-LOC\nexpresses O\nanger O\nat O\nconduct O\nof O\nsome O\nIraqi B-MISC\ndiplomats O\nin O\nAmman B-LOC\nwhich O\nare O\nincompatible O\nwith O\ndiplomatic O\ntraditions O\n. O\n\nAD B-ORG\nDUSTOUR I-ORG\n\n- O\nKabariti B-PER\nand O\nparliament O\nspeaker O\nmeet O\nto O\ndiscuss O\nways O\nto O\nreactivate O\nparliament O\n's O\nlegislative O\nrole O\n. O\n\nAL B-ORG\nASWAQ I-ORG\n\n- O\nState O\nsecurity O\ncourt O\nstarts O\ninvestigating O\nsuspects O\nin O\nunrest O\n. O\n\n-DOCSTART- O\n\nNetanyahu B-PER\n, O\nWeizman B-PER\nconsult O\non O\nArafat B-PER\ninvitation O\n. O\n\nJERUSALEM B-LOC\n1996-08-25 O\n\nIsraeli B-MISC\nPresident O\nEzer B-PER\nWeizman I-PER\n, O\nweighing O\na O\npossible O\nmeeting O\nwith O\nYasser B-PER\nArafat I-PER\n, O\nconsulted O\non O\nSunday O\nwith O\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\n, O\na O\nspokesman O\nsaid O\n. O\n\nWeizman B-PER\nand O\nNetanyahu B-PER\nmet O\nat O\nthe O\npresident O\n's O\nofficial O\nJerusalem B-LOC\nresidence O\nand O\nplanned O\nto O\nspeak O\nto O\nthe O\nmedia O\nat O\nthe O\nend O\nof O\ntheir O\ntalks O\n, O\nthe O\nprime O\nminister O\n's O\nspokesman O\nsaid O\n. O\n\nEarlier O\n, O\nthe O\ndirector O\nof O\nthe O\npresident O\n's O\noffice O\ndenied O\na O\nreport O\nin O\nIsrael B-LOC\n's O\nYedioth B-ORG\nAhronoth I-ORG\nnewspaper O\nthat O\nWeizman B-PER\nhad O\nalready O\ninvited O\nArafat B-PER\nto O\nhis O\nprivate O\nhome O\nfor O\ntalks O\nin O\nthe O\ncoming O\nweek O\non O\nthe O\nfuture O\nof O\nthe O\nIsrael-PLO B-MISC\npeace O\nprocess O\n. O\n\nBut O\nthe O\nofficial O\n, O\nAryeh B-PER\nShumer I-PER\n, O\nsaid O\nit O\nwas O\nonly O\nfitting O\nthat O\nWeizman B-PER\nand O\nArafat B-PER\nshould O\ntalk O\nafter O\nthe O\nPalestinian B-MISC\nleader O\nsent O\nthe O\nIsraeli B-MISC\npresident O\na O\nletter O\nwhich O\nYedioth B-ORG\nAhronoth I-ORG\nreported O\ncontained O\nan O\nemotional O\nappeal O\nto O\nsave O\nthe O\npeace O\nproces O\n. O\n\nThe O\nnewspaper O\nsaid O\nNetanyahu B-PER\n, O\nwho O\nis O\ncool O\nto O\nmeeting O\nArafat B-PER\nhimself O\n, O\nopposed O\ntalks O\nbetween O\nWeizman B-PER\nand O\nthe O\nPalestinian B-MISC\npresident O\n. O\n\nAfter O\nMoslem B-MISC\nsuicide O\nbombers O\nkilled O\n59 O\npeople O\nin O\nIsrael B-LOC\nin O\nFebruary O\nand O\nMarch O\n, O\nWeizman B-PER\ncalled O\nfor O\npeace O\nefforts O\nwith O\nthe O\nPLO B-ORG\nto O\nbe O\nsuspended O\n. O\n\nShumer B-PER\nsaid O\nhis O\ncurrent O\nposition O\nwas O\nthat O\nthe O\npeace O\nprocess O\nmust O\ncontinue O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nIsrael B-LOC\n- O\nAug O\n25 O\n. O\n\nJERUSALEM B-LOC\n1996-08-25 O\n\nThese O\nare O\nsome O\nof O\nthe O\nleading O\nstories O\nin O\nIsraeli B-MISC\nnewspapers O\non O\nSunday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nHAARETZ B-ORG\n\n- O\nPalestinian B-MISC\nPresident O\nArafat B-PER\nopens O\ncivilian O\nstruggle O\nagainst O\nIsrael B-LOC\n, O\ncalls O\non O\nPalestinians B-MISC\nto O\nbuild O\nin O\nself-rule O\nareas O\n. O\n\n- O\nSeven O\nministers O\nand O\ngovernor O\nof O\nBank B-ORG\nof I-ORG\nIsrael I-ORG\nwill O\nvisit O\nthe O\nUnited B-LOC\nStates I-LOC\nat O\nthe O\nend O\nof O\nSeptember O\nand O\nin O\nOctober O\n. O\n\n- O\nIsrael B-LOC\nbans O\nplane O\ndonated O\nby O\nthe O\nNetherlands B-LOC\nto O\nArafat B-PER\nto O\nland O\nat O\nGaza B-LOC\nairport O\n. O\n\n- O\nFormer O\nprime O\nminister O\nPeres B-PER\nto O\nMorocco B-LOC\ntoday O\n. O\n\nYEDIOTH B-ORG\nAHRONOTH I-ORG\n\n- O\nIsraeli B-MISC\nPresident O\nWeizman B-PER\ninvited O\nPalestinian B-MISC\nPresident O\nArafat B-PER\nto O\nmeet O\nhim O\nat O\nhis O\nprivate O\nresidence O\n. O\n\n- O\nNetanyahu B-PER\nopposes O\ntransit O\ncamps O\nfor O\nforeign O\nworkers O\nfacing O\nexpulsion O\n. O\n\n- O\nForeign O\nMinister O\nLevy B-PER\nto O\nvisit O\nEgypt B-LOC\nsoon O\n. O\n\nMAARIV B-ORG\n\n- O\nPalestinian B-ORG\nAuthority I-ORG\nhas O\ntaken O\nover O\neducation O\nin O\nEast B-LOC\nJerusalem I-LOC\n. O\n\n- O\nSyrian B-MISC\narmoured O\ncolumns O\non O\nthe O\nmove O\nin O\nLebanon B-LOC\n. O\n\n- O\nShimon B-PER\nPeres I-PER\nto O\nMorocco B-LOC\n, O\nwill O\nstay O\nat O\nking O\n's O\nprivate O\nresidence O\n. O\n\nJERUSALEM B-ORG\nPOST I-ORG\n\n- O\nPalestinian B-MISC\nMinister O\nErekat B-PER\nsays O\nIsrael-PLO B-MISC\ntalks O\nwill O\nbegin O\nby O\nSeptember O\n2 O\n. O\n\n- O\nPrime O\nminister O\nnames O\nformer O\ngeneral O\nAvraham B-PER\nTamir I-PER\nto O\nstaff O\nafter O\nfailing O\nto O\nestablish O\nnational O\nsecurity O\ncouncil O\n. O\n\n- O\nCabinet O\nputs O\noff O\ndecision O\non O\nforeign O\nworkers O\n. O\n\n- O\nInternal O\nSecurity O\nMinister O\nKahalani B-PER\nwarns O\ncabinet O\nof O\nincrease O\nin O\norganised O\ncrime O\n. O\n\n-DOCSTART- O\n\nVoting O\nbegins O\nin O\nsecond O\nround O\nof O\nLebanese B-MISC\nelection O\n. O\n\nTRIPOLI B-LOC\n, O\nLebanon B-LOC\n1996-08-25 O\n\nVoting O\nbegan O\non O\nSunday O\nin O\nnorth O\nLebanon B-LOC\nin O\nthe O\nsecond O\nround O\nof O\nparliamentary O\nelections O\nwith O\n580,000 O\nvoters O\neligible O\nto O\nchoose O\n28 O\nmembers O\nof O\nthe O\n128-member O\nparliament O\n. O\n\nA O\nthin O\ntrickle O\nof O\nvoters O\nbegan O\ncasting O\ntheir O\nballots O\nin O\nthis O\nnorthern O\nport O\ncity O\nfor O\nthe O\nfive O\nrival O\nlists O\nof O\ncandidates O\nas O\npolling O\nstations O\nopened O\nat O\n7 O\na.m. O\n( O\n0400 O\ngmt O\n) O\n. O\n\n-DOCSTART- O\n\nIsraeli B-MISC\npresident O\ninvites O\nArafat B-PER\nto O\nhome O\n- O\npaper O\n. O\n\nJERUSALEM B-LOC\n1996-08-25 O\n\nIsraeli B-MISC\nPresident O\nEzer B-PER\nWeizman I-PER\nhas O\ninvited O\nYasser B-PER\nArafat I-PER\nto O\nmeet O\nhim O\nat O\nhis O\nprivate O\nhome O\n, O\nIsrael B-LOC\n's O\nbiggest O\nnewspaper O\nsaid O\non O\nSunday O\n. O\n\nThe O\nYedioth B-ORG\nAhronoth I-ORG\ndaily O\nreported O\nthat O\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\n, O\nwho O\nhas O\nsaid O\nhe O\nhas O\nno O\ndesire O\nto O\nhold O\ntalks O\nwith O\nthe O\nPalestinian B-MISC\npresident O\n, O\nopposes O\nthe O\nmeeting O\ndue O\nto O\nbe O\nheld O\nthis O\ncoming O\nweek O\n. O\n\nThe O\nnewspaper O\nsaid O\nWeizman B-PER\nscheduled O\nthe O\nmeeting O\nat O\nhis O\nprivate O\nresidence O\nin O\nthe O\ncentral O\nIsraeli B-MISC\nvillage O\nof O\nCaesarea B-LOC\nafter O\nArafat B-PER\nsent O\nhim O\nan O\nemotional O\nappeal O\n\" O\nto O\nsave O\nthe O\npeace O\nprocess O\n\" O\n. O\n\nNetanyahu B-PER\nmet O\nWeizman B-PER\nlast O\nTuesday O\nand O\nvoiced O\nhis O\nopposition O\n, O\nYedioth B-ORG\nsaid O\n. O\n\n\" O\nI O\nam O\nprepared O\nto O\npostpone O\nthe O\nmeeting O\nunder O\none O\ncondition O\n-- O\nthat O\nyou O\ngive O\nme O\na O\ncommitment O\nright O\nnow O\nto O\nmeet O\nArafat B-PER\nyourself O\nwithin O\n10 O\ndays O\n, O\n\" O\nthe O\npaper O\nquoted O\nWeizman B-PER\nas O\ntelling O\nNetanyahu B-PER\n. O\n\nIt O\nsaid O\nNetanyahu B-PER\nhad O\nyet O\nto O\ngive O\nWeizman B-PER\nan O\nanswer O\n. O\n\nThe O\noffice O\nof O\nIsraeli B-MISC\npresident O\nis O\nlargely O\nceremonial O\n. O\n\nBut O\nWeizman B-PER\n, O\na O\nformer O\ndefence O\nminister O\nand O\nan O\narchitect O\nof O\nIsrael B-LOC\n's O\npeace O\ntreaty O\nwith O\nEgypt B-LOC\n, O\nhas O\nspoken O\nout O\nfrequently O\non O\nthe O\npeace O\nprocess O\nwith O\nthe O\nPalestinians B-MISC\n-- O\nat O\ntimes O\nurging O\nthe O\nformer O\nLabour B-ORG\ngovernment O\nto O\nslow O\nit O\ndown O\n. O\n\n-DOCSTART- O\n\nCorporate O\nAmerica B-LOC\ntaking O\nnew O\nview O\non O\ncompensation O\n. O\n\nAnne B-PER\nMurray I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-23 O\n\nCorporate O\nAmerica B-LOC\nis O\nplanning O\nmajor O\nchanges O\nin O\nemployee O\ncompensation O\nin O\nthe O\nnext O\nfew O\nyears O\n, O\naccording O\nto O\na O\nrecent O\nstudy O\n. O\n\nWhat O\nit O\ncomes O\ndown O\nto O\nis O\nthis O\n: O\nIf O\nyou O\n're O\nhighly O\nskilled O\n, O\nyou O\n'll O\nbenefit O\nnicely O\n. O\n\nBut O\nif O\nyou O\n're O\nnot O\nand O\ncannot O\ncontribute O\nto O\nyour O\nemployer O\n's O\ngoals O\n, O\nyou O\n'll O\nbe O\npaid O\nless O\n. O\n\nThe O\nsurvey O\n, O\nconducted O\nin O\nlate O\n1995 O\nand O\nthe O\nearly O\npart O\nof O\nthis O\nyear O\nby O\nmanagement O\nconsulting O\nfirm O\nTowers B-ORG\nPerrin I-ORG\n, O\nshowed O\nthat O\nthe O\nfocus O\nwill O\nbe O\non O\nan O\nemployee O\n's O\noverall O\nvalue O\nto O\nthe O\ncompany O\n's O\nbottom O\nline O\n-- O\nrather O\nthan O\nhow O\nwell O\nan O\nemployee O\nperforms O\na O\nspecific O\ntask O\n. O\n\nPresently O\n, O\nfor O\nexample O\n, O\nif O\nan O\naccountant O\n's O\njob O\ninvolves O\ndoing O\nfive O\nspecific O\ntasks O\n, O\nhe O\nor O\nshe O\ncan O\nexpect O\na O\ncertain O\nsalary O\n, O\nsaid O\nSandra B-PER\nO'Neal I-PER\n, O\na O\nTowers B-ORG\nPerrin I-ORG\nprincipal O\n. O\n\nIn O\nthe O\nfuture O\n, O\nthe O\naccountant O\nwill O\nbe O\nevaluated O\nsolely O\non O\n\" O\nknowledge O\n, O\nskill O\nand O\nabilities O\n, O\n\" O\nshe O\nsaid O\n. O\n\nIn O\naddition O\nto O\nusing O\naccounting O\nskills O\n, O\nthe O\naccountant O\nwill O\nalso O\nhave O\nto O\nbe O\ncreative O\n, O\nwork O\nwell O\nin O\na O\nteam O\n, O\nbe O\nsensitive O\nto O\ncustomer O\nneeds O\nand O\nset O\nproductivity O\ngoals O\n. O\n\n\" O\nThe O\ngood O\nnews O\nis O\n, O\nif O\nyou O\n're O\nhighly O\nskilled O\nand O\nhave O\nmany O\nabilities O\n, O\nyou O\n'll O\nbe O\npaid O\nmore O\n, O\n\" O\nsaid O\nO'Neal B-PER\n. O\n\n\" O\nThe O\nbad O\nnews O\nis O\n, O\nif O\nyou O\n're O\nnot O\nskilled O\nand O\nca O\nn't O\ncontribute O\nto O\na O\nteam O\n, O\nto O\ncustomer O\nservice O\nand O\nthe O\norganisation O\n's O\ngoals O\n, O\nyou O\n'll O\nbe O\npaid O\nless O\n. O\n\" O\n\nOf O\nthe O\n750 O\nmid-to-large O\nsize O\ncorporations O\nsurveyed O\n, O\n81 O\npercent O\nhad O\nundergone O\na O\nmajor O\nrestructuring O\nin O\nthe O\nlast O\nthree O\nyears O\n, O\nand O\nmore O\nthan O\ntwo-thirds O\nreported O\nthat O\nproductivity O\nand O\nprofits O\nwere O\nup O\nas O\nresult O\n. O\n\nNext O\non O\nthe O\nagenda O\nfor O\nthese O\nfirms O\nis O\ndeveloping O\na O\nnew O\ncompensation O\nstructure O\n, O\nand O\n78 O\npercent O\nreport O\nthat O\nthey O\nare O\nconsidering O\na O\nnew O\n, O\nskills-based O\nplan O\nfor O\nboth O\nmanagement O\nand O\nnon-management O\nemployees O\n. O\n\nThis O\ncoming O\nshift O\n, O\nO'Neal B-PER\nsaid O\n, O\n\" O\nis O\nnot O\njust O\nisolated O\nor O\na O\nfad O\n. O\n\nIt O\n's O\nan O\ninexorable O\nchange O\n. O\n\" O\n\nAfter O\nWorld B-MISC\nWar I-MISC\nII I-MISC\n, O\ncorporations O\nadopted O\na O\n\" O\nmilitary O\nmodel O\n\" O\ncreating O\nhierarchical O\norganisations O\nwhere O\n\" O\nthe O\nconcept O\nof O\ndefined O\ntasks O\nworked O\ngreat O\n, O\n\" O\nshe O\nsaid O\n. O\n\nBut O\nas O\nthe O\neconomy O\nbecame O\nglobal O\n, O\ncustomers O\nwere O\nmore O\ndemanding O\nand O\nproblems O\nbecame O\nmore O\ncomplex O\n. O\n\n\" O\nMulti-layers O\nkept O\nmanagement O\nat O\na O\ndistance O\nfrom O\nits O\ncustomers O\n, O\n\" O\nO'Neal B-PER\nsaid O\n. O\n\nNow O\norganisations O\nmust O\nchange O\nto O\nstay O\ncompetitive O\n. O\n\nO'Neal B-PER\nsays O\nfirms O\nwill O\nplace O\na O\ngreater O\nemphasis O\non O\nteams O\nand O\nteam O\nperformance O\nin O\ngiving O\nraises O\n. O\n\nIf O\nyour O\nteam O\ndoes O\nwell O\n, O\nyou O\n'll O\ndo O\nwell O\n. O\n\nIf O\nit O\ndoes O\nn't O\ndo O\nwell O\n, O\ndo O\nn't O\nexpect O\na O\nraise O\n. O\n\nIs O\nthis O\nfair O\nto O\nan O\nemployee O\nwho O\ncan O\ngo O\nthe O\ndistance O\nbut O\nis O\non O\na O\nteam O\nthat O\nca O\nn't O\nkeep O\nup O\n? O\n\n\" O\nThat O\n's O\nan O\nimportant O\nquestion O\nwe O\nused O\nto O\nask O\na O\nlot O\n, O\n\" O\nsaid O\nO'Neal B-PER\n. O\n\" O\n\nIt O\n's O\nnot O\na O\nquestion O\nwe O\nask O\nany O\nmore O\n. O\n\nThe O\nmore O\nimportant O\nquestion O\nis O\n-- O\n' O\nDo O\nwe O\nhave O\nresults O\n? O\n' O\n\n\" O\n\nTo O\nget O\nthose O\nresults O\n, O\n27 O\npercent O\nof O\nthe O\ncompanies O\nsurveyed O\nplan O\nto O\neliminate O\nbase O\npay O\nincreases O\nin O\nfavour O\nof O\ncash O\nbonuses O\nand O\nincentives O\n, O\nsuch O\nas O\nemployee O\nand O\nteam O\naward O\nprogrammes O\nand O\neducation O\n. O\n\nCompanies O\nthat O\ncan O\nchange O\ntheir O\nculture O\nand O\nview O\nemployees O\nas O\nbusiness O\npartners O\nwill O\ndo O\nwell O\n, O\nO'Neal B-PER\nsaid O\n. O\n\nFor O\nexample O\n, O\nthe O\nsurvey O\nrated O\nsome O\nparticipants O\nin O\nthe O\nsurvey O\nas O\n\" O\nhigh-performing O\n\" O\ncompanies O\n, O\nbased O\non O\ntheir O\nreturn O\non O\nequity O\nabove O\n16 O\npercent O\n. O\n\nThose O\ncompanies O\nalso O\nsaid O\nthey O\nalready O\noffer O\nemployees O\nvariable O\npay O\nand O\nbusiness O\neducation O\n, O\ngive O\ntheir O\nmanagers O\nmore O\ncontrol O\nover O\npay O\ndecisions O\nand O\ncelebrate O\nemployee O\nand O\nteam O\nsuccess O\n. O\n\n\" O\nThey O\nrespect O\nemployees O\nmore O\n, O\nthey O\ntrust O\nemployees O\nmore O\nand O\nthey O\nvalue O\ntheir O\nemployees O\nmore O\n, O\n\" O\nO'Neal B-PER\nsaid O\n. O\n\n\" O\nThe O\nkey O\nto O\nsuccess O\nat O\nhigh-performance O\ncompanies O\nis O\nengaging O\nemployees O\nin O\na O\nbusiness O\npartnership O\n. O\n\nIt O\nwill O\nimprove O\na O\ncompany O\n's O\nbottom O\nline O\n. O\n\" O\n\n-DOCSTART- O\n\nBelgian B-MISC\npolice O\narrest O\ndetective O\nin O\nDutroux B-PER\naffair O\n. O\n\nGeert B-PER\nde I-PER\nClercq I-PER\n\nNEUFCHATEAU B-LOC\n, O\nBelgium B-LOC\n1996-08-25 O\n\nInvestigators O\narrested O\na O\nsenior O\npolice O\ndetective O\non O\nSunday O\nin O\nconnection O\nwith O\ntheir O\ninquiries O\ninto O\nBelgium B-LOC\n's O\nchild O\nsex O\nscandal O\n, O\nPublic O\nProsecutor O\nMichel B-PER\nBourlet I-PER\nsaid O\n. O\n\n\" O\nGeorges B-PER\nZicot I-PER\nwas O\narrested O\nand O\nwill O\nbe O\ncharged O\nwith O\ntruck O\ntheft O\n, O\ninsurance O\nfraud O\nand O\ndocument O\nforgery O\n, O\n\" O\nBourlet B-PER\ntold O\na O\nnews O\nconference O\n. O\n\nHe O\nsaid O\nthere O\nhad O\nbeen O\nsearches O\nat O\nthree O\nsites O\non O\nSunday O\n, O\nincluding O\none O\nat O\nthe O\nCharleroi B-LOC\njudicial O\npolice O\nheadquarters O\nwhere O\nZicot B-PER\nworked O\n. O\n\nZicot B-PER\n, O\n45 O\n, O\nis O\na O\nspecialist O\nin O\ntackling O\nvehicle O\ntheft O\n. O\n\nBelgian B-MISC\nmedia O\nreported O\nthat O\nhe O\nhad O\nbeen O\nquestioned O\ntwice O\nin O\nthe O\npast O\ntwo O\nyears O\nabout O\nthefts O\nbut O\nreleased O\nboth O\ntimes O\n. O\n\nHe O\nwas O\npromoted O\nto O\nchief O\ndetective O\nearlier O\nthis O\nyear O\n. O\n\nBourlet B-PER\nsaid O\ntwo O\nother O\npeople O\nhad O\nalso O\nbeen O\narrested O\n. O\n\nOne O\nwas O\nGerard B-PER\nPignon I-PER\n, O\nthe O\nowner O\nof O\na O\nwarehouse O\nwhere O\nstolen O\nvehicles O\nwere O\nallegedly O\nstored O\n. O\n\nThe O\nother O\nwas O\ninsurer O\nThierry B-PER\nDehaan I-PER\n. O\n\nBourlet B-PER\nsaid O\nthe O\ninvestigation O\ninto O\nthe O\nvehicle O\ntheft O\nring O\nwould O\nbe O\nadded O\nto O\nthe O\ninquiry O\ninto O\nthe O\npaedophile O\nsex O\nscandal O\nin O\nwhich O\nfive O\nother O\npeople O\nhave O\nalready O\nbeen O\narrested O\n. O\n\nHe O\nsaid O\nthe O\nconnection O\nwas O\nthrough O\nBernard B-PER\nWeinstein I-PER\n, O\nan O\naccomplice O\nof O\nconvicted O\nchild O\nrapist O\nMarc B-PER\nDutroux I-PER\n-- O\nthe O\ncentral O\nfigure O\nin O\nthe O\npaedophile O\nscandal O\nthat O\nhas O\nsent O\nshockwaves O\nacross O\nEurope B-LOC\n. O\n\nWeinstein B-PER\nwas O\nfound O\ndead O\nlast O\nweekend O\nalongside O\nthe O\nbodies O\nof O\neight-year-olds O\nJulie B-PER\nLejeune I-PER\nand O\nMelissa B-PER\nRusso I-PER\nin O\na O\nhouse O\nbelonging O\nto O\nDetroux B-PER\n, O\nwho O\nsaid O\nthey O\nstarved O\nto O\ndeath O\nearlier O\nthis O\nyear O\n, O\nnine O\nmonths O\nafter O\nbeing O\nabducted O\nin O\nJune O\n1995 O\n. O\n\nTwo O\nother O\ngirls O\nhave O\nbeen O\nrescued O\nand O\npolice O\nare O\nhunting O\nfor O\nat O\nleast O\ntwo O\nmore O\nwho O\nDutroux B-PER\nhas O\nadmitted O\nkidnapping O\na O\nyear O\nago O\n. O\n\n\" O\nDutroux B-PER\nhas O\nadmitted O\nkilling O\nWeinstein B-PER\nafter O\na O\ndisagreement O\nbetween O\nthe O\naccomplices O\nin O\nan O\naffair O\nof O\ntruck O\ntheft O\n, O\n\" O\nBourlet B-PER\nsaid O\n. O\n\nAnother O\nfour O\npeople O\nwere O\nalso O\nquestioned O\nat O\nthe O\nweekend O\nbut O\nhad O\nnot O\nbeen O\ndetained O\n, O\nBourlet B-PER\nadded O\n. O\n\nAnne B-PER\nThily I-PER\n, O\npublic O\nprosecutor O\nin O\nthe O\neastern O\ncity O\nof O\nLiege B-LOC\nwhere O\nJulie B-PER\nand O\nMelissa B-PER\nlived O\n, O\nsaid O\nthis O\nwas O\na O\nmajor O\ncase O\ninvolving O\nsome O\n50 O\ninvestigators O\n-- O\nincluding O\ntwo O\nfrom O\nthe O\nU.S. B-LOC\nFederal B-ORG\nBureau I-ORG\nof I-ORG\nInvestigation I-ORG\n. O\n\n-DOCSTART- O\n\nFrench B-MISC\n1997 O\nbudget O\ndue O\naround O\nSeptember O\n10 O\n- O\nJuppe B-PER\n. O\n\nBREGANCON B-LOC\n, O\nFrance B-LOC\n1996-08-25 O\n\nPrime O\nMinister O\nAlain B-PER\nJuppe I-PER\nsaid O\non O\nSunday O\nthe O\ndraft O\n1997 O\nbudget O\nand O\nplans O\nfor O\nfunding O\nthe O\nsocial O\nsecurity O\nsystem O\nwould O\nbe O\npubished O\naround O\nSeptember O\n10 O\n. O\n\n\" O\nThe O\ntexts O\nare O\npractically O\nready O\n, O\n\" O\nhe O\ntold O\nreporters O\nafter O\na O\nweekend O\nof O\ntalks O\nwith O\nPresident O\nJacques B-PER\nChirac I-PER\nin O\na O\nRiviera B-LOC\nfortress O\n. O\n\nThe O\nbudget O\nhad O\nbeen O\nwidely O\nexpected O\na O\nweek O\nor O\nso O\nlater O\n. O\n\n-- O\nParis B-LOC\nnewsroom O\n+331 O\n4221 O\n5452 O\n\n-DOCSTART- O\n\n19 O\ndie O\nas O\nbus O\nfalls O\nin O\nriver O\nin O\nPakistani B-LOC\nKashmir I-LOC\n. O\n\nMUZAFFARABAD B-LOC\n, O\nPakistan B-LOC\n1996-08-25 O\n\nA O\nbus O\nfell O\nfrom O\na O\nmountain O\nroad O\ninto O\na O\nriver O\nin O\nPakistan-ruled B-MISC\nAzad B-LOC\n( I-LOC\nfree I-LOC\n) I-LOC\nKashmir I-LOC\non O\nSunday O\n, O\nkilling O\nat O\nleast O\n19 O\npeople O\nand O\ninjuring O\n11 O\n, O\npolice O\nsaid O\n. O\n\nThey O\nsaid O\ndead O\nincluded O\nfive O\nrefugees O\nfrom O\nthe O\nIndian-ruled B-MISC\npart O\nof O\nKashmir B-LOC\n, O\nwhere O\nMoslem B-MISC\nmilitants O\nhave O\nwaged O\na O\nseparatist O\nrevolt O\nsince O\nearly O\n1990 O\n. O\n\nThe O\npolice O\nsaid O\n14 O\nof O\nthe O\n45 O\npassengers O\non O\nthe O\nbus O\ndied O\ninstantly O\nwhen O\nthe O\nvehicle O\nfell O\ninto O\nKunar B-LOC\nriver O\nfrom O\na O\nnarrow O\nroad O\nleading O\nfrom O\nthe O\nstate O\ncapital O\nMuzaffarabad B-LOC\nto O\nthe O\nnearby O\nPakistani B-MISC\ntown O\nof O\nGarhi B-LOC\nHabibullah I-LOC\nnorthwest O\n. O\n\nFive O\npeople O\ndied O\nlater O\nin O\nhospital O\n. O\n\n-DOCSTART- O\n\nNorth B-MISC\nAfghan I-MISC\nhighway O\nopening O\nput O\noff O\n, O\nradio O\nsays O\n. O\n\nISLAMABAD B-LOC\n1996-08-25 O\n\nThe O\nplanned O\nreopening O\nof O\nAfghanistan B-LOC\n's O\nmain O\nnorthern O\nSalang B-LOC\nhighway O\nas O\na O\nresult O\nof O\npeace O\ntalks O\nwith O\nan O\nopposition O\nalliance O\nhas O\nbeen O\nput O\noff O\nuntil O\nWednesday O\n, O\nofficial O\nKabul B-ORG\nRadio I-ORG\nsaid O\non O\nSunday O\n. O\n\nThe O\nembattled O\nAfghan B-MISC\ngovernment O\nsaid O\nlast O\nweek O\nthat O\nthe O\nKabul-Salang B-LOC\nhighway O\nwould O\nbe O\nopened O\non O\nMonday O\nor O\nTuesday O\nfollowing O\ntalks O\nwith O\nthe O\nSupreme B-ORG\nCoordination I-ORG\nCouncil I-ORG\nalliance I-ORG\nled O\nby O\nJumbish-i-Milli B-ORG\nmovement O\nof O\npowerful O\nopposition O\nwarlord O\nGeneral O\nAbdul B-PER\nRashid I-PER\nDostum I-PER\n. O\n\nThe O\nradio O\nsaid O\non O\nSunday O\nthe O\npostponement O\nof O\nthe O\nopening O\nhad O\nbeen O\nmade O\ndue O\nto O\n\" O\nprecautions O\n\" O\n. O\n\nIt O\ndid O\nnot O\nelaborate O\n. O\n\nThe O\nSalang B-LOC\nhighway O\n, O\nAfghanistan B-LOC\n's O\nmain O\nroute O\nto O\nCentral B-LOC\nAsia I-LOC\n, O\nhas O\nbeen O\ncontrolled O\nby O\nDostum B-PER\nsince O\nhe O\nbegan O\nfighting O\nPresident O\nBurhanuddin B-PER\nRabbani I-PER\n's O\ngovernment O\nin O\nKabul B-LOC\nin O\nJanuary O\n1994 O\nin O\nalliance O\nwith O\nHezb-i-Islami B-ORG\nparty O\nleader O\nGulbuddin B-PER\nHekmatyar I-PER\n, O\nthen O\nprime O\nminister O\nbut O\nrival O\nto O\nthe O\npresident O\n. O\n\nHekmatyar B-PER\nrejoined O\nthe O\ngovernment O\nas O\nprime O\nminister O\nlast O\nJune O\nunder O\na O\npeace O\npact O\nwith O\nRabbani B-PER\nand O\nhas O\nsince O\nbeen O\ntrying O\nto O\npersuade O\nother O\nopposition O\nfactions O\nto O\nfollow O\nsuit O\n. O\n\nEarlier O\nthis O\nmonth O\n, O\nJumbish B-PER\ndenied O\na O\nKabul B-LOC\ngovernment O\nstatement O\nthat O\nthe O\ntwo O\nsides O\nhad O\nagreed O\nto O\na O\nceasefire O\nin O\nthe O\nnorth O\n. O\n\n-DOCSTART- O\n\nStudents O\nburn O\nHasina B-PER\neffigy O\n, O\nbattle O\npolice O\n. O\n\nAnis B-PER\nAhmed I-PER\n\nDHAKA B-LOC\n1996-08-25 O\n\nStudents O\nbacked O\nby O\nopposition O\nparties O\nbattled O\npolice O\nand O\nburned O\nan O\neffigy O\nof O\nPrime O\nMinister O\nSheikh O\nHasina B-PER\nduring O\na O\nstrike O\nin O\nthe O\nnorth O\nBangladeshi B-MISC\ntown O\nof O\nBogra B-LOC\non O\nSunday O\n. O\n\nThe O\nstrikers O\nbarricaded O\nstreets O\n, O\nattacked O\nthe O\nlocal O\noffice O\nof O\nthe O\nruling O\nAwami B-ORG\nLeague I-ORG\n, O\nfought O\nrunning O\nbattles O\nwith O\npolice O\nand O\nset O\nalight O\nhundreds O\nof O\ncopies O\nof O\nthe O\npopular O\n\" O\nJanakantha B-ORG\n\" O\nnewspaper O\n, O\nalleging O\nit O\nwas O\npro-government O\n. O\n\nPolice O\nused O\nbatons O\nand O\nteargas O\nto O\ntry O\nto O\ndisperse O\nstudents O\nwho O\nwere O\nthrowing O\nstones O\nand O\nhome-made O\nbombs O\n, O\nwitnesses O\nsaid O\n. O\n\nThe O\nstrike O\n, O\ncalled O\nby O\nthe O\nmain O\nopposition O\nBangladesh B-ORG\nNationalist I-ORG\nParty I-ORG\n( O\nBNP B-ORG\n) O\n, O\nto O\ndenounce O\nthe O\ndeaths O\nof O\nfour O\nstudents O\nkilled O\nby O\npolice O\nover O\nthe O\nlast O\nfew O\ndays O\n, O\ncoincided O\nwith O\na O\nvisit O\nto O\nthe O\narea O\nby O\nHasina B-PER\n. O\n\nLocal O\nofficials O\nsaid O\none O\npoliceman O\nwas O\nkilled O\nby O\ngunshots O\nduring O\nclashes O\nwith O\npro-opposition O\nstudents O\non O\nThursday O\n. O\n\nHasina B-PER\ntold O\na O\ncross O\nsection O\nof O\npeople O\nat O\nthe O\nBogra B-LOC\npolice O\nheadquarters O\non O\nSunday O\nthat O\nthe O\ngovernment O\nhad O\nalready O\nsuspended O\nthree O\npolice O\nofficers O\nand O\nordered O\na O\njudicial O\nprobe O\ninto O\nthe O\nviolent O\nincidents O\n. O\n\nThe O\nprime O\nminister O\noffered O\nfinancial O\ngrants O\nto O\nthe O\nfamilies O\nof O\nthose O\nkilled O\n, O\nordered O\nthe O\nbest O\npossible O\nmedical O\ncare O\nfor O\nthe O\ninjured O\nand O\nurged O\nBogra B-LOC\nresidents O\nto O\ncall O\noff O\nthe O\nstrike O\n. O\n\nOpposition O\nlegislators O\nwalked O\nout O\nof O\nparliament O\nin O\nDhaka B-LOC\non O\nSunday O\ndenouncing O\n\" O\nunprecedented O\npolice O\nbarbarity O\n\" O\nagainst O\nopposition O\nstudents O\nand O\nsupporters O\n. O\n\nThey O\nrenewed O\ntheir O\ncall O\nfor O\nthe O\nresignation O\nof O\nHome O\n( O\nInterior O\n) O\nMinister O\nRafiqul B-PER\nIslam I-PER\n. O\n\nHundreds O\nof O\npolice O\nraided O\nthe O\nDhaka B-LOC\nuniversity O\non O\nSunday O\n, O\narresting O\nnearly O\n30 O\noutsiders O\nwho O\nhad O\nbeen O\nliving O\nin O\nstudent O\ndormitories O\nand O\nseizing O\nweapons O\n, O\nuniversity O\nofficials O\nsaid O\n. O\n\nPolice O\nstormed O\nten O\nresidence O\nhalls O\non O\nthe O\ncampus O\n, O\nflushed O\nout O\npeople O\nat O\ngunpoint O\nand O\nsearched O\ntheir O\nbaggage O\n. O\n\nThey O\nseized O\nrevolvers O\n, O\nsawn-off O\nrifles O\n, O\nshotguns O\nand O\nknives O\n. O\n\nThe O\nstudents O\nwere O\nlater O\nallowed O\nto O\nreturn O\n. O\n\nThe O\nswoop O\nfollowed O\nthe O\nresignation O\nof O\nthe O\nuniversity O\n's O\nVice-Chancellor O\nDr. O\nEmajuddin B-PER\nAhmed I-PER\non O\nSaturday O\nover O\nthe O\ndeteriorating O\nlaw O\nand O\norder O\nsituation O\non O\nthe O\ncampus O\n. O\n\nAuthorities O\nclosed O\ndown O\nthe O\n28,000-student O\nuniversity O\non O\nWednedsay O\nfollowing O\ngunbattles O\nbetween O\nstudents O\nand O\npolice O\n. O\n\nPolice O\nsaid O\nthey O\nfought O\narmed O\nactivists O\nfrom O\nthe O\nBNP B-ORG\n, O\nheaded O\nby O\nformer O\nprime O\nminister O\nBegum B-PER\nKhaleda I-PER\nZia I-PER\n. O\n\nHasina B-PER\ntold O\npolice O\nthe O\nhome O\nministry O\nhad O\nalready O\ngiven O\na O\n\" O\nblanket O\norder O\n\" O\nto O\narrest O\nterrorists O\nand O\npossessors O\nof O\nillegal O\nfirearms O\nirrespective O\nof O\ntheir O\npolitical O\nidentities O\n. O\n\nNearly O\n100 O\nstudents O\nhave O\nbeen O\ninjured O\nin O\nthe O\nclashes O\nin O\nDhaka B-LOC\nand O\nBogra B-LOC\n, O\npolice O\ntold O\nreporters O\n. O\n\n-DOCSTART- O\n\n16 O\ndie O\nas O\nbus O\ncrashes O\nin O\nPakistani B-LOC\nKashmir I-LOC\n. O\n\nMUZAFFARABAD B-LOC\n, O\nPakistan B-LOC\n1996-08-25 O\n\nAt O\nleast O\n16 O\npeople O\nwere O\nkilled O\nand O\nseveral O\ninjured O\non O\nSunday O\nwhen O\na O\nbus O\nfell O\nfrom O\na O\nmountain O\nroad O\ninto O\na O\nravine O\non O\na O\nriver O\nbank O\nin O\nPakistan-ruled B-MISC\nAzad B-LOC\n( I-LOC\nfree I-LOC\n) I-LOC\nKashmir I-LOC\n, O\npolice O\nsaid O\n. O\n\nThey O\nsaid O\n14 O\nout O\nof O\n45 O\npassengers O\non O\nthe O\nbus O\ndied O\ninstantly O\nwhen O\nthe O\nvehicle O\nfell O\nfrom O\nthe O\nnarrow O\nroad O\nwhile O\non O\nits O\nway O\nfrom O\nthe O\nstate O\ncapital O\nMuzaffarabad B-LOC\nto O\nthe O\nnearby O\nPakistani B-MISC\ntown O\nof O\nGarhi B-LOC\nHabibullah I-LOC\nin O\nthe O\nnorthwest O\n. O\n\nTwo O\ndied O\nlater O\nin O\nhospital O\n. O\n\n-DOCSTART- O\n\nFEATURE O\n- O\nFertile O\nUkraine B-LOC\nfaces O\ndrought O\nof O\ncash O\nand O\nrain O\n. O\n\nIrene B-PER\nMarushko I-PER\n\nBATKIVSHCHYNA B-LOC\nCOLLECTIVE I-LOC\nFARM I-LOC\n, O\nUkraine B-LOC\n1996-08-26 O\n\nFour O\nshiny O\nnew O\ngreen-and-yellow O\nJohn B-PER\nDeere I-PER\ncombines O\nparked O\nat O\nthis O\n1,750-hectare O\n( O\n4,325-acre O\n) O\nfarm O\nin O\nthe O\ngrain-growing O\nregions O\nsouth O\nof O\nKiev B-LOC\ndo O\nn't O\nfill O\nits O\nchief O\nagronomist O\nwith O\nenthusiasm O\n. O\n\n\" O\nThey O\ndid O\na O\ngood O\njob O\nthis O\nyear O\n, O\nbut O\nthey O\nneed O\ngood O\ndiesel O\nand O\ngood O\nengine O\noil O\n, O\n\" O\nsaid O\nIvan B-PER\nOdnosum I-PER\n. O\n\" O\n\nGod B-PER\nhelp O\nus O\nif O\nthere O\nis O\na O\nbreakdown O\n, O\n\" O\nhe O\nsaid O\nof O\nthe O\nmachinery O\n, O\nloaned O\nto O\nthe O\nfarm O\nafter O\nthe O\nUkrainian B-MISC\ngovernment O\nbought O\nit O\nearlier O\nthis O\nyear O\n. O\n\nThe O\ncountry O\n's O\ngrain O\nharvest O\nthis O\nyear O\nis O\nforecast O\nto O\nfall O\nby O\nmore O\nthan O\n23 O\npercent O\nto O\nonly O\n28 O\nmillion O\ntonnes O\nand O\ntwo O\nharsh O\nfactors O\nare O\nto O\nblame O\n. O\n\nA O\ndrought O\nscoured O\nthe O\nsteppes O\nin O\nMay O\nand O\nJune O\n, O\nstunting O\nthe O\ngrowing O\nwheat O\n. O\n\nAnd O\nthe O\nfarming O\nsector O\n, O\nmaking O\nthe O\npainful O\ntransition O\nfrom O\nSoviet B-MISC\ncentral O\nplanning O\nto O\na O\nmarket O\neconomy O\nsimply O\nhas O\nno O\nmoney O\n. O\n\nUkraine B-LOC\n's O\nblack O\nsoil O\nis O\nso O\nfertile O\nthat O\na O\ndiplomat O\ndescribed O\nit O\nas O\n\" O\nrich O\nenough O\nto O\ngrow O\nrubber O\nboots O\n\" O\n. O\n\nBut O\nrecently O\nUkraine B-LOC\nhas O\nbeen O\nlosing O\nits O\nreputation O\nas O\na O\nbreadbasket O\nof O\nEurope B-LOC\n, O\nearned O\nin O\nthe O\nyears O\nbefore O\nbrutal O\nforced O\ncollectivisation O\nunder O\nSoviet B-MISC\ndictator O\nJosef B-PER\nStalin I-PER\n. O\n\n\" O\nThe O\nwheat O\nwill O\nnot O\nbe O\nof O\na O\ngood O\nquality O\nthis O\nyear O\n, O\n\" O\nsaid O\nHryhory B-PER\nBorsuk I-PER\n, O\na O\nscientist O\nat O\nthe O\nMironivka B-ORG\nWheat I-ORG\nInstitute I-ORG\n, O\nrun O\nby O\nthe O\nUkrainian B-ORG\nAcademy I-ORG\nof I-ORG\nAgrarian I-ORG\nSciences I-ORG\n. O\n\n\" O\nThe O\ntemperature O\non O\nthe O\nground O\nreached O\n62 O\ndecrees O\nCelsius B-MISC\n( O\n143.60 O\nFahrenheit O\n) O\nthis O\nsummer O\n. O\n\nWe O\n've O\nnever O\nseen O\nanything O\nso O\nbad O\n, O\n\" O\nhe O\nsaid O\nin O\nan O\ninterview O\nin O\nhis O\noffice O\n, O\nunlit O\nsince O\nthe O\ngovernment O\ncut O\noff O\nelectricity O\nbecause O\nof O\nunpaid O\npower O\nbills O\n. O\n\nThe O\nharvest O\nis O\ngathered O\nin O\nthe O\ndry O\nareas O\n, O\nbut O\nrainfall O\nin O\nWestern B-LOC\nUkraine I-LOC\nhas O\ndelayed O\nharvesting O\nthere O\n. O\n\nWhile O\nMironivka B-ORG\n's O\nscientists O\n, O\nsome O\nunpaid O\nfor O\nmonths O\n, O\ncarry O\non O\ndeveloping O\nnew O\nstrains O\nof O\nwheat O\nresistant O\nto O\nUkraine B-LOC\n's O\nextreme O\ncontinental O\nclimate O\n, O\nBorsuk B-PER\nsaid O\nthe O\nlack O\nof O\ncash O\nin O\nUkraine B-LOC\n's O\nagricultural O\nsector O\nis O\nas O\nbad O\nas O\nthe O\ndrought O\n. O\n\nCollective O\nfarms O\nand O\nUkraine B-LOC\n's O\nnascent O\nprivate O\nfarming O\nsector O\nhave O\nno O\nmoney O\nfor O\nfertiliser O\n, O\nno O\nmoney O\nfor O\nherbicides O\nand O\npesticides O\n, O\nno O\nmoney O\nto O\nrepair O\nold O\nor O\nbuy O\nnew O\nmachinery O\n, O\nno O\nmoney O\nfor O\nfuel O\n, O\nand O\nnone O\nto O\nbuy O\ngood O\nseed O\n. O\n\nThis O\nyear O\n's O\nharvest O\nis O\ndown O\nfrom O\nlast O\nyear O\n's O\n36.5 O\nmillion O\ntonne O\nharvest O\n, O\nwhich O\nin O\nturn O\ncompares O\nwith O\n50 O\nmillion O\ntonnes O\nin O\n1990 O\n, O\nthe O\nyear O\nbefore O\nindependence O\n. O\n\nThe O\ndecline O\nis O\nall O\nthe O\nworse O\nfor O\npeople O\nwho O\nrecall O\nwasteful O\nSoviet B-MISC\ntimes O\n, O\nwhen O\nthe O\nKremlin B-LOC\nimported O\ngrain O\nbut O\npriced O\nbread O\nso O\ncheaply O\nthat O\npeople O\nbought O\nit O\nto O\nfeed O\ntheir O\npigs O\n. O\n\n\" O\nAgriculture O\nis O\nvery O\nexpensive O\n, O\nand O\nthere O\nare O\nno O\nsolutions O\nto O\nour O\nproblems O\non O\nthe O\nhorizon O\n, O\n\" O\nsaid O\nOdnosum B-PER\n. O\n\nHe O\nsaid O\nhis O\nfarm O\n, O\nits O\n260 O\nworkers O\nnow O\nreadying O\nthe O\nfields O\nfor O\nwinter O\nwheat O\nsowing O\n, O\nexpected O\nthe O\nland O\nto O\nyield O\n5.2 O\ntonnes O\nper O\nhectare O\n( O\n2.5 O\nacres O\n) O\nbut O\nended O\nup O\nwith O\n3.9 O\ntonnes O\n-- O\nstill O\nbetter O\nthan O\nthe O\nnational O\naverage O\nof O\n2.11 O\ntonnes O\nper O\nhectare O\nthis O\nyear O\n. O\n\n\" O\nWe O\ndid O\nnot O\nhave O\nmoney O\nfor O\nfertiliser O\n, O\nwe O\n're O\nin O\ndebt O\nfor O\nfuel O\n, O\nand O\nwe O\n're O\nborrowing O\ndiesel O\n, O\n\" O\nOdnosum B-PER\nsaid O\n. O\n\nA O\nfew O\nkilometres O\n( O\nmiles O\n) O\ndown O\nthe O\ntwo-lane O\nroad O\nwhich O\npasses O\nOdnosum B-PER\n's O\nfarm O\n, O\nwhere O\nthe O\noccasional O\nhorse-drawn O\nbuggy O\npasses O\nby O\n, O\nis O\nthe O\n1,700-hectare O\n( O\n4,200-acre O\n) O\nShevchenko B-PER\ncollective O\nfarm O\n, O\nbuilt O\nnext O\nto O\na O\nvillage O\nstill O\nneat O\nand O\ntidy O\ndespite O\npost-Soviet B-MISC\ndecay O\n. O\n\nChief O\nAccountant O\nNatalya B-PER\nSypron I-PER\nsaid O\nthe O\ncollective O\nis O\nstrapped O\nfor O\ncash O\n, O\nearlier O\nthis O\nyear O\nbartering O\n220 O\ntonnes O\nof O\ngrain O\nfor O\ndiesel O\nto O\nfuel O\nsix O\nrickety O\ngrain O\ncombines O\nand O\ntractors O\nbadly O\nin O\nneed O\nof O\nrepairs O\nand O\nbasic O\nmaintenance O\n. O\n\nThe O\naverage O\nfamily O\nearns O\n160-200 O\nmillion O\nkarbovanets O\na O\nyear O\n( O\n$ O\n800 O\n- O\n$ O\n1,000 O\n) O\n-- O\nbut O\nmany O\nhave O\nnot O\nbeen O\npaid O\nin O\nmonths O\n, O\nSoprun B-PER\nsaid O\n. O\n\" O\n\nPeople O\nare O\nworking O\nout O\nof O\ntheir O\nown O\ndedication O\n. O\n\" O\n\nBorsuk B-PER\nsaid O\nthe O\nfarm O\nsector O\nhas O\ntwo O\noptions O\n: O\n\" O\nWe O\ncan O\nsit O\ndown O\nand O\ncry O\n, O\nor O\nwe O\ncan O\ndo O\nsomething O\n. O\n\" O\n\nHe O\nsaid O\nthe O\ngovernment O\nplans O\nto O\nincrease O\nthe O\nsowing O\nof O\nthe O\nwinter O\nwheat O\nwhich O\nwill O\nbe O\nharvested O\nnext O\nyear O\n. O\n\nPlanted O\nin O\nlate O\nsummer O\nand O\nearly O\nautumn O\n, O\nthe O\ngrain O\nis O\nUkraine B-LOC\n's O\nlargest O\nexport O\nitem O\nand O\ntraditionally O\ngrows O\nbetter O\nthan O\nsummer O\nwheat O\nin O\nUkraine B-LOC\n's O\nsoil O\n. O\n\nFurther O\nplans O\n, O\nhe O\nsaid O\n, O\ncalled O\nfor O\nfull O\nprovision O\nof O\nresources O\nlike O\nfertiliser O\nand O\nherbicides O\nfor O\n25 O\npercent O\nof O\nUkraine B-LOC\n's O\narable O\nland O\nnext O\nyear O\n, O\nfor O\n50 O\npercent O\nin O\n1998 O\nand O\n100 O\npercent O\nof O\nthe O\nland O\nin O\n1999 O\n. O\n\n\" O\nIf O\nwe O\nfollow O\nthis O\nwe O\n'll O\nbe O\nable O\nto O\nsell O\n10 O\nmillion O\ntonnes O\nof O\ngrain O\nby O\nthe O\nyear O\n2000 O\n, O\n\" O\nBorkus B-PER\nsaid O\n. O\n\nThe O\ngovernment O\nhas O\nbeen O\ntrying O\nto O\nphase O\nout O\nhuge O\nsubsidies O\nto O\nthe O\nfarm O\nsector O\n, O\nand O\nin O\na O\nmove O\nback O\nto O\npre-Soviet B-MISC\ndays O\nhas O\ngiven O\nup O\nto O\n50 O\nhectares O\n( O\n124 O\nacres O\n) O\nof O\nland O\nto O\nsome O\n36,000 O\nprivate O\nfarmers O\nwilling O\nto O\ngo O\nit O\nalone O\n. O\n\nCollective O\nfarms O\nwill O\nlast O\nfor O\nthe O\nnext O\nfew O\nyears O\n, O\nbecause O\nmost O\nprivate O\nfarms O\nnow O\nonly O\nproduce O\nenough O\nto O\nfeed O\nthemselves O\nwith O\nmaybe O\na O\nlittle O\nextra O\nto O\nsell O\n, O\nsaid O\none O\nprivate O\nfarmer O\n: O\n\" O\nIn O\nthe O\nfuture O\n, O\nmaybe O\n, O\nbut O\nit O\n's O\nbetter O\nnot O\nto O\nhurry O\n. O\n\n\" O\nCollectivisation O\nbrought O\nus O\na O\nlot O\nof O\npain O\n. O\n\nAnd O\nit O\nwent O\ntoo O\nfast O\n. O\n\nPrivatising O\ntoo O\nquickly O\ncan O\nalso O\nhave O\na O\nnegative O\noutcome O\n. O\n\" O\n\n-DOCSTART- O\n\nGencor B-ORG\nswells O\nprofit O\ndespite O\nsetbacks O\n. O\n\nMelanie B-PER\nCheary I-PER\n\nJOHANNESBURG B-LOC\n1996-08-26 O\n\nGencor B-ORG\nLtd I-ORG\non O\nMonday O\nsaid O\nit O\nhad O\nswelled O\nits O\nyear O\nattributable O\nprofit O\nand O\nstreamlined O\noperations O\nto O\nstrengthen O\nit O\nfor O\nthe O\ncurrent O\nfinancial O\nyear O\ndespite O\na O\nvariety O\nof O\ndivisional O\nsetbacks O\n. O\n\nAnnouncing O\nthe O\ngroup O\n's O\nresults O\nfor O\nthe O\nyear O\nended O\nJune O\n30 O\n, O\nchairman O\nBrian B-PER\nGilbertson I-PER\nsaid O\n: O\n\" O\nHappily O\nthe O\nstrong O\nimprovement O\nin O\nfinancial O\nperformance O\nis O\nnot O\nan O\nillusion O\narising O\nfrom O\nthe O\nrecent O\nweakness O\nof O\nthe O\nrand O\nrelative O\nto O\nthe O\ndollar O\n. O\n\" O\n\nGencor B-ORG\nraised O\nattributable O\nearnings O\nto O\n1,803 O\nmillion O\nrand O\nfrom O\n1,003 O\nmillion O\nrand O\npreviously O\n- O\nin O\ndollar O\nterms O\nan O\nincrease O\nto O\n$ O\n469 O\nmillion O\nfrom O\n$ O\n279 O\nmillion O\n- O\nand O\nwon O\ndespite O\nthe O\ngroup O\n's O\nImpala B-ORG\nPlatinum I-ORG\nHoldings I-ORG\nLtd I-ORG\nposting O\ndismal O\nresults O\n. O\n\n\" O\nNot O\neverything O\nhas O\ngone O\nwell O\n. O\n\nWe O\n've O\nhad O\nsubstantial O\nproduction O\ndifficulties O\nat O\na O\nnumber O\nof O\nour O\noperations O\n. O\n\nThe O\nmost O\nobvious O\none O\nwith O\nthe O\ngreatest O\neffect O\non O\nthe O\ncorporation O\nwas O\nat O\nImpala B-ORG\nwhere O\nwe O\nhad O\nthe O\nfurnace O\nfailure O\n, O\n\" O\nGilbertson B-PER\nsaid O\n. O\n\nImplats B-ORG\nposted O\nyear O\nattributable O\nprofit O\nof O\n176 O\nmillion O\nrand O\nfrom O\n281 O\nmillion O\npreviously O\n. O\n\nNot O\nonly O\ndid O\nthe O\ncompany O\nlock O\nin O\n3.92 O\nrand O\nper O\ndollar O\nin O\nFebruary O\n/ O\nMarch O\n, O\nbut O\nit O\nsuffered O\noutput O\nlosses O\ndue O\nto O\na O\nfurnace O\nshutdown O\nlast O\nAugust O\n. O\n\nThe O\nrand O\nwas O\nlast O\nbid O\nat O\n4.5350 O\nagainst O\nthe O\ndollar O\n. O\n\nNor O\nwas O\nImplats B-ORG\nthe O\nonly O\noperation O\nto O\nfail O\noutput O\ntargets O\n. O\n\nIngwe B-ORG\nCoal I-ORG\nCorporation I-ORG\nLtd I-ORG\nwas O\nhit O\nhard O\nby O\nheavy O\nrains O\n. O\n\nIt O\nforfeited O\nnearly O\none O\nmillion O\ntonnes O\nof O\nproduction O\nto O\nflooding O\nat O\nits O\nmines O\nin O\nMpumulanga B-LOC\nprovince O\n. O\n\nBut O\nGilbertson B-PER\nsaid O\nthe O\ngreatest O\ngloom O\nin O\nthe O\nyear O\ncame O\nfrom O\nthe O\nEuropean B-ORG\nCommission I-ORG\n's O\nblocking O\nof O\nImplats B-ORG\n' O\nproposed O\nmerger O\nwith O\nLonrho B-ORG\nPlc I-ORG\n's O\nplatinum O\ninterests O\n. O\n\n\" O\nThe O\nbig O\ndisappointment O\nfor O\nthe O\nyear O\nwas O\nthe O\nfailure O\nof O\nthe O\nplatinum O\nmerger O\n. O\n\nFrom O\nGencor B-ORG\n's O\nperspective O\nwe O\nare O\ntaking O\nthe O\nposition O\nthat O\nit O\nis O\nnot O\non O\n, O\n\" O\nGilbertson B-PER\nsaid O\n. O\n\nLooking O\nahead O\nto O\nthe O\ncurrent O\nfinancial O\nyear O\n, O\nhe O\nsaid O\nthat O\nGencor B-ORG\nwould O\nboost O\nearnings O\nfurther O\n. O\n\n\" O\nGencor B-ORG\nis O\nwell O\nplaced O\nto O\ntake O\nup O\nthe O\nchallenges O\nof O\nthe O\nfuture O\n. O\n\nThe O\ngroup O\nis O\nsoundly O\nstructured O\nand O\nprudently O\nfinanced O\nand O\nis O\nblessed O\nwith O\nan O\nexcellent O\nportfolio O\nof O\nworld-class O\nbusinesses O\n. O\n\nI O\nthink O\nwe O\ncan O\nlook O\nforward O\nto O\nfurther O\ngrowth O\n\" O\n. O\n\nCiting O\nthe O\ndisposal O\nof O\nGencor B-ORG\n's O\nstake O\nin O\nindustrial O\nholdings O\ngroup O\nMalbak B-ORG\nLtd I-ORG\nfor O\none O\nbillion O\nrand O\namong O\nother O\nsmaller O\ndisposals O\n, O\nGilbertson B-PER\nsaid O\nGencor B-ORG\nhad O\npruned O\nits O\nportfolio O\nto O\nconcentrate O\non O\ncore O\nassets O\n. O\n\n\" O\nWe O\n've O\ntried O\nto O\nclean O\nup O\nour O\noverall O\nportfolio O\nby O\ndisposing O\nof O\nnon-core O\nassets O\n. O\n\nThe O\nbiggest O\nof O\nthose O\nwas O\nMalbak B-ORG\n. O\n\nOverall O\na O\nvery O\nsubstantial O\npruning O\n... O\n\nleaving O\nGencor B-ORG\nclearly O\nstructured O\nalong O\ncommodity O\nlines O\n, O\n\" O\nGilbertson B-PER\nsaid O\n. O\n\nHe O\nadded O\nthat O\nthe O\ngroup O\nstill O\nhad O\nabout O\n85 O\nmillion O\nrand O\nafter O\ntax O\ninvested O\nin O\nvarious O\nshares O\n, O\nwhich O\nwere O\nmarket O\nfor O\ndisposal O\nwhen O\nrequired O\n. O\n\nReferring O\nto O\nGencor B-ORG\n's O\nincreased O\n41.5 O\npercent O\nstake O\nin O\nIngwe B-ORG\n, O\nGilbertson B-PER\nsaid O\nthe O\ngroup O\nwould O\nwait O\nfor O\ncoal O\nshares O\nto O\nbe O\ncheaper O\nbefore O\nconsidering O\nsnapping O\nup O\nmore O\n. O\n\n\" O\nI O\nthink O\nwe O\nwould O\nhave O\nliked O\nto O\nhave O\nmore O\nof O\nIngwe B-ORG\nbut O\nit O\n's O\nthe O\nquestion O\nof O\nadding O\nvalue O\n. O\n\nWhen O\nwe O\nbought O\nthe O\nshares O\nwe O\nbought O\n... O\n\nat O\nquite O\na O\nbit O\nlower O\nthan O\nthe O\nprice O\nis O\nnow O\n... O\n\nmaybe O\nif O\nwe O\njust O\nwait O\nanother O\nfew O\nyears O\nfor O\nthe O\nnext O\ndownturn O\nin O\ncoal O\n. O\n\" O\n\nFinally O\n, O\nGilbertson B-PER\nsaid O\na O\ngrowing O\nproportion O\nof O\nGencor B-ORG\n's O\nincome O\nwas O\ncoming O\nfrom O\noffshore O\nand O\nunlisted O\ninvestments O\n. O\n\n-- O\nJohannesburg B-LOC\nnewsroom O\n+27 O\n11 O\n482-1003 O\n\n-DOCSTART- O\n\nAdvanced B-ORG\nMedical I-ORG\nbuying O\nIVAC B-ORG\nMedical I-ORG\n. O\n\nSAN B-LOC\nDIEGO I-LOC\n1996-08-26 O\n\nAdvanced B-ORG\nMedical I-ORG\nInc. I-ORG\nsaid O\nMonday O\nit O\nwill O\nbuy O\nIVAC B-ORG\nMedical I-ORG\nSystems I-ORG\nInc. I-ORG\n, O\na O\nformer O\nEli B-ORG\nLilly I-ORG\n& I-ORG\nCo I-ORG\n. O\n\nunit O\n, O\nfor O\nabout O\n$ O\n400 O\nmillion O\nin O\ncash O\n, O\ncreating O\none O\nof O\nthe O\nworld O\n's O\nlargest O\nmakers O\nof O\nintravenous O\ninfusion O\ntherapy O\nproducts O\n. O\n\nUnder O\nthe O\nagreement O\n, O\nIVAC B-ORG\nand O\nAdvanced B-ORG\nMedical I-ORG\n's O\nwholly O\nowned O\nsubsidiary O\n, O\nIMED B-ORG\nCorp. I-ORG\n, O\nwill O\nmerge O\nto O\nform O\na O\nnew O\ncompany O\nthat O\nwill O\ndevelop O\nand O\nmanufacture O\ninfusion O\npumps O\nthat O\nregulate O\nthe O\namount O\nof O\nintravenous O\nfluid O\nbeing O\nadministered O\nto O\na O\npatient O\n, O\nas O\nwell O\nas O\nproprietary O\ndisposable O\nproducts O\n. O\n\nThe O\ncombined O\ncompany O\nwill O\nhave O\nestimated O\nrevenues O\nof O\n$ O\n353 O\nmillion O\n. O\n\nAdvanced B-ORG\nMedical I-ORG\n, O\nthrough O\nIMED B-ORG\n, O\nis O\nalready O\none O\nof O\nthe O\nnation O\n's O\nlargest O\ndevelopers O\nand O\nmanufacturers O\nof O\nintravenous O\ninfusion O\npumps O\nand O\nproprietary O\ndisposable O\nproducts O\n. O\n\nIt O\nhas O\nsales O\nin O\n38 O\nforeign O\ncountries O\n. O\n\nSan B-MISC\nDiego-based I-MISC\nIVAC B-ORG\nis O\na O\nmajor O\nprovider O\nof O\ninfusion O\nsystems O\nand O\nrelated O\ntechnologies O\nto O\nthe O\nhealth-care O\nindustry O\n. O\n\nIt O\nhas O\nmanufacturing O\nplants O\nin O\nSan B-LOC\nDiego I-LOC\n; O\nCreedmoor B-LOC\n, O\nN.C. B-LOC\n; O\nHampshire B-LOC\n, O\nEngland B-LOC\n; O\nand O\nTijuana B-LOC\n, O\nMexico B-LOC\n, O\nand O\ndistributes O\nits O\nprodcuts O\nin O\nmore O\nthan O\n120 O\ncountries O\n. O\n\nEli B-ORG\nLilly I-ORG\nsold O\nIVAC B-ORG\non O\nDec. O\n31 O\n, O\n1994 O\nto O\nDLJ B-ORG\nMerchant I-ORG\nBanking I-ORG\nPartners I-ORG\nLP I-ORG\n, O\nRiver B-ORG\nMedical I-ORG\nInc. I-ORG\nand O\nother O\ninvestors O\n. O\n\nAdvanced B-ORG\nMedical I-ORG\nsaid O\nit O\nexpects O\nto O\ntake O\nan O\nunspecified O\none-time O\ncharge O\nto O\npay O\nfor O\nthe O\nmerger O\n. O\n\nIt O\ndid O\nnot O\nsay O\nwhen O\nthe O\ncharge O\nwould O\nbe O\ntaken O\n. O\n\n\" O\nThe O\naddition O\nof O\nIVAC B-ORG\nis O\nexpected O\nto O\ncontribute O\nto O\nfinancial O\nresults O\nin O\nthe O\nfull O\nsecond O\nquarter O\nof O\n1997 O\n, O\n\" O\nthe O\ncompanies O\nsaid O\n. O\n\nThe O\nmerger O\nwill O\nadd O\nto O\nboth O\ncompanies O\n' O\nhistorical O\nleadership O\nin O\ninfusion O\ntherapy O\nand O\ntechnology-based O\ndrug O\ndelivery O\ndevices O\n, O\nthey O\nsaid O\n. O\n\nIn O\n1968 O\n, O\nIVAC B-ORG\nintroduced O\nthe O\nworld O\n's O\nfirst O\ninfusion O\ntherapy O\nmonitoring O\ndevice O\n. O\n\nA O\nyear O\nlater O\nIVAC B-ORG\nimproved O\nits O\nsystem O\nwith O\nthe O\naddition O\nof O\nan O\nIV O\npump O\nthat O\nregulated O\nthe O\nflow O\nof O\nliquids O\nthrough O\npositive O\npressure O\n. O\n\nIMED B-ORG\nintroduced O\nthe O\nworld O\n's O\nfirst O\nvolumetric O\ninfusion O\npump O\nin O\n1974 O\n. O\n\nIMED B-ORG\nhad O\nprofits O\nof O\n$ O\n1.7 O\nmillion O\n, O\nor O\n6 O\ncents O\nper O\nfully O\ndiluted O\ncommon O\nshare O\n, O\non O\n$ O\n53.9 O\nmillion O\nin O\nrevenues O\nin O\nthe O\nfirst O\nhalf O\nof O\n1996 O\n. O\n\nExcluding O\nthe O\neffect O\nof O\na O\none-time O\nrestructuring O\ncharge O\nof O\n$ O\n17.4 O\nmillion O\n, O\nIVAC B-ORG\nhad O\nnet O\nincome O\nof O\n$ O\n4.2 O\nmillion O\non O\nnet O\nsales O\nof O\n$ O\n112.8 O\nmillion O\nfor O\nthe O\n1996 O\nfirst O\nhalf O\n. O\n\nAdvanced B-ORG\nMedical I-ORG\nreported O\nprofits O\nof O\n$ O\n8.4 O\nmillion O\non O\nsales O\nof O\n$ O\n29.2 O\nmillion O\nin O\nthe O\nquarter O\nended O\nJune O\n30 O\n. O\n\nWilliam B-PER\nJ. I-PER\nMercer I-PER\n, O\nIVAC B-ORG\npresident O\nand O\nchief O\nexecutive O\nofficer O\n, O\nwill O\nbecome O\nthe O\npresident O\nand O\nCEO O\nof O\nAdvanced B-ORG\nMedical I-ORG\n. O\n\nHe O\nled O\nthe O\ntransition O\nof O\nIVAC B-ORG\nto O\na O\nprivately O\nheld O\ncompany O\nand O\nwas O\npreviously O\nsenior O\nvice O\npresident O\nat O\nMallinckrodt B-ORG\nGroup I-ORG\nInc I-ORG\n. O\n\nJoseph B-PER\nKuhn I-PER\n, O\nAdvanced B-ORG\nMedical I-ORG\nand O\nIMED B-ORG\npresident O\n, O\nwill O\nbecome O\nthe O\nnew O\ncompany O\n's O\nexecutive O\nvice O\npresident O\nand O\nchief O\nfinancial O\nofficer O\n. O\n\nThe O\ndeal O\nis O\nexpected O\nto O\nclose O\nby O\nthe O\nfirst O\nquarter O\nof O\n1997 O\n, O\nsubject O\nto O\nregulatory O\napproval O\n. O\n\nIt O\nhas O\nalready O\nbeen O\napproved O\nby O\nboth O\ncompanies O\n' O\nboards O\n. O\n\n-DOCSTART- O\n\nDow B-MISC\nrises O\non O\nPhilip B-ORG\nMorris I-ORG\n, O\nother O\nstocks O\nlower O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-26 O\n\nThe O\nDow B-MISC\nJones I-MISC\nindustrial O\naverage O\nopened O\nslightly O\nhigher O\non O\nMonday O\n, O\nboosted O\nby O\nPhilip B-ORG\nMorris I-ORG\n, O\nwhich O\ngained O\nfour O\nto O\n92 O\n. O\n\nOther O\nshares O\nwere O\nslightly O\nlower O\n, O\nmirroring O\nbonds O\n. O\n\nThe O\nDow B-MISC\nwas O\nup O\neight O\nto O\n5,731 O\n, O\nwhile O\nthe O\nNASDAQ B-MISC\nIndex I-MISC\nwas O\noff O\nfractionally O\nto O\n1,143 O\nand O\nthe O\nS&P B-MISC\nIndex I-MISC\ndown O\none O\nto O\n666 O\n. O\n\nNew B-ORG\nYork I-ORG\nStock I-ORG\nExchange I-ORG\nadvances O\nlagged O\ndeclines O\nby O\n476/698 O\nwhile O\nNASDAQ B-MISC\nadvances O\nled O\ndeclines O\n837/763 O\n. O\n\nThe O\n30-year O\nU.S. B-ORG\nTreasury I-ORG\nbond O\nwas O\noff O\n2/32 O\nto O\nyield O\n6.96 O\npercent O\n. O\n\n-DOCSTART- O\n\nRUGBY B-MISC\nLEAGUE I-MISC\n- O\nST B-ORG\nHELENS I-ORG\nCLINCH O\nSUPER O\nLEAGUE O\nTITLE O\n. O\n\nST B-LOC\nHELENS I-LOC\n, O\nEngland B-LOC\n1996-08-26 O\n\nSt B-ORG\nHelens I-ORG\ncompleted O\ntheir O\nfirst O\nleague O\nand O\nChallenge B-MISC\nCup I-MISC\ndouble O\nin O\n30 O\nyears O\non O\nMonday O\nwhen O\nthey O\nthrashed O\nWarrington B-ORG\n66-14 O\nto O\nclinch O\nthe O\ninaugural O\nSuper B-MISC\nLeague I-MISC\ntitle O\n. O\n\nSt B-ORG\nHelens I-ORG\nsecured O\nthe O\ntwo O\npoints O\nthey O\nneeded O\nin O\nthe O\nlast O\ngame O\nof O\nthe O\nseason O\nat O\nKnowsley B-LOC\nRoad I-LOC\nto O\nwin O\ntheir O\nfirst O\nchampionship O\nsince O\n1975 O\nand O\ntheir O\nfirst O\ndouble O\nsince O\n1966 O\n. O\n\nIn O\nrain-soaked O\nconditions O\n, O\ncentre O\nAlan B-PER\nHunte I-PER\ngrabbed O\na O\nhat-trick O\nof O\ntries O\n, O\nwhile O\nTommy B-PER\nMartyn I-PER\n, O\nAnthony B-PER\nSullivan I-PER\nand O\nPaul B-PER\nNewlove I-PER\neach O\nscored O\ntwo O\n. O\n\nCaptain O\nand O\ngoalkicker O\nBobbie B-PER\nGoulding I-PER\nscored O\n18 O\npoints O\n. O\n\nSt B-ORG\nHelens I-ORG\n's O\ntriumph O\nmarked O\nthe O\nend O\nof O\nWigan B-ORG\n's O\nseven-year O\nreign O\nas O\nBritish B-MISC\nchampions O\n. O\n\nSt B-ORG\nHelens I-ORG\nneeded O\nto O\nwin O\non O\nMonday O\nto O\ntake O\nthe O\ntitle O\n-- O\na O\ndefeat O\nor O\ndraw O\nwould O\nhave O\nallowed O\nWigan B-ORG\ntheir O\neighth O\nconsecutive O\nchampionship O\n. O\n\nThey O\nwere O\nalso O\nthe O\ntoast O\nof O\nLondon B-ORG\nBroncos I-ORG\n, O\nwho O\nmanaged O\nto O\nscrape O\ninto O\nthe O\ntop O\nfour O\nahead O\nof O\nWarrington B-ORG\nand O\nqualify O\nfor O\nthe O\nend-of-season O\nplay-offs O\n. O\n\nBradford B-ORG\nfinished O\nthird O\n. O\n\nSt B-ORG\nHelens I-ORG\nhave O\nnow O\nset O\ntheir O\nsights O\non O\ntaking O\nthe O\ntreble O\nby O\nwinning O\nthe O\nend-of-season O\npremiership O\nwhich O\nbegins O\nwith O\nnext O\nSunday O\n's O\nsemifinal O\nagainst O\nLondon B-ORG\n. O\n\n-DOCSTART- O\n\nRALLYING O\n- O\n1,000 B-MISC\nLAKES I-MISC\nRALLY I-MISC\nRESULT O\n/ O\nWORLD O\nCHAMPIONSHIP O\nSTANDINGS O\n. O\n\nJYVASKLYA B-LOC\n, O\nFinland B-LOC\n1996-08-26 O\n\nResult O\nof O\nthe O\n1,000 B-MISC\n\nLakes B-MISC\nRally I-MISC\nwhich O\nended O\non O\nMonday O\n: O\n\n1. O\nTommi B-PER\nMakinen I-PER\n( O\nFinland B-LOC\n) O\nMitsubishi B-MISC\nLancer I-MISC\n4 O\nhours O\n4 O\nminutes O\n\n13 O\nseconds O\n\n2. O\nJuha B-PER\nKankkunen I-PER\n( O\nFinland B-LOC\n) O\nToyota B-MISC\nCelica I-MISC\n46 O\nseconds O\nbehind O\n\n3. O\nJarmo B-PER\nKytolehto I-PER\n( O\nFinland B-LOC\n) O\nFord B-MISC\nEscort I-MISC\n2:37 O\n\n4. O\nMarcus B-PER\nGronholm I-PER\n( O\nFinland B-LOC\n) O\nToyota B-MISC\nCelica I-MISC\n2:42 O\n\n5. O\nKenneth B-PER\nEriksson I-PER\n( O\nSweden B-LOC\n) O\nSubaru B-MISC\nImpreza I-MISC\n3:22 O\n\n6. O\nThomas B-PER\nRadstrom I-PER\n( O\nSweden B-LOC\n) O\nToyota B-MISC\nCelica I-MISC\n4.09 O\n\n7. O\nSebastian B-PER\nLindholm I-PER\n( O\nFinland B-LOC\n) O\nFord B-MISC\nEscort I-MISC\n5:17 O\n\n8. O\nLasse B-PER\nLampi I-PER\n( O\nFinland B-LOC\n) O\nMitsubishi B-MISC\nLancer I-MISC\n12:01 O\n\n9. O\nRui B-PER\nMadeira I-PER\n( O\nPortugal B-LOC\n) O\nToyota B-MISC\nCelica I-MISC\n16:34 O\n\n10. O\nAngelo B-PER\nMedeghini I-PER\n( O\nItaly B-LOC\n) O\nSubaru B-MISC\nImpreza I-MISC\n18:28 O\n\n-DOCSTART- O\n\nRALLYING O\n- O\nMAKINEN B-PER\nSTEPS O\nUP O\nTITLE O\nBID O\nWITH O\nLAKES B-MISC\nWIN O\n. O\n\nJYVASKYLA B-LOC\n, O\nFinland B-LOC\n1996-08-26 O\n\nTommi B-PER\nMakinen I-PER\ntook O\na O\nsignificant O\nstep O\ntowards O\nbecoming O\nworld O\nrally O\nchampion O\nwith O\na O\nbrilliant O\nvictory O\nin O\nthe O\n1000 B-MISC\nLakes I-MISC\nRally I-MISC\non O\nMonday O\n. O\n\nMitsubishi B-ORG\ndriver O\nMakinen B-PER\nstopped O\nexperienced O\nfellow O\nFinn B-MISC\nJuha B-PER\nKankkunen I-PER\nin O\nhis O\ntracks O\non O\nthe O\nfinal O\nday O\nof O\nthe O\n1,452-km O\nrally O\n, O\ndoubling O\nhis O\nlead O\non O\nthe O\nfirst O\ntwo O\ndecisive O\nstages O\n. O\n\n\" O\nThis O\nwas O\nthe O\nmost O\ndifficult O\nwin O\n- O\nthree O\ndays O\nat O\n125 O\npercent O\neffort O\n, O\n\" O\nsaid O\nMakinen B-PER\n, O\nwhose O\nsuccess O\ncompleted O\nhis O\n1,000 B-MISC\nLakes I-MISC\nhat-trick O\n. O\n\nKankkunen B-PER\nwas O\nrunner-up O\nin O\nhis O\nToyota B-ORG\nas O\nFinland B-LOC\n's O\nJarmo B-PER\nKytolehto I-PER\nproduced O\na O\nremarkable O\ndrive O\nto O\nfinish O\nthird O\nin O\nhis O\nFord B-ORG\n. O\n\nSwede B-MISC\nKenneth B-PER\nEriksson I-PER\nkept O\nSubaru B-ORG\nin O\nthe O\nhunt O\nfor O\nthe O\nmanufacturers O\n' O\ntitle O\nwith O\nfifth O\nplace O\nin O\nspite O\nof O\na O\ngearbox O\nproblem O\nthat O\nnearly O\nforced O\nhim O\noff O\nthe O\nroad O\nclose O\nto O\nthe O\nend O\nof O\nthe O\nevent O\n. O\n\nMaakinen B-PER\n's O\nand O\nMitsubishi B-ORG\n's O\npositions O\nwere O\nstrengthened O\nby O\nthe O\nlate O\nretirement O\nof O\nSpain B-LOC\n's O\nCarlos B-PER\nSainz I-PER\nwhen O\nhis O\nFord B-ORG\ngearbox O\nfailed O\n. O\n\nMakinen B-PER\n, O\nwith O\n95 O\npoints O\n, O\nnow O\nleads O\nhis O\nnearest O\nchampionship O\nrival O\n, O\nSainz B-PER\n, O\nby O\n32 O\npoints O\n. O\n\n-DOCSTART- O\n\nRALLYING O\n- O\nMAKINEN B-PER\nWINS O\n1,000 B-MISC\nLAKES I-MISC\nRALLY I-MISC\n. O\n\nJYVASKYLA B-LOC\n, O\nFinland B-LOC\n1996-08-26 O\n\nTommi B-PER\nMakinen I-PER\nof O\nFinland B-LOC\n, O\ndriving O\na O\nMitsubishi B-ORG\n, O\non O\nMonday O\nwon O\nthe O\n1,000 B-MISC\nLakes I-MISC\nRally I-MISC\n, O\nsixth O\nround O\nof O\nthe O\nworld O\nchampionship O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSHARPE B-PER\nHITS O\nWINNER O\nTO O\nEASE O\nPRESSURE O\nON O\nLEEDS B-ORG\n. O\n\nLEEDS B-LOC\n, O\nEngland B-LOC\n1996-08-26 O\n\nWinger O\nLee B-PER\nSharpe I-PER\nhit O\na O\nsuperb O\nstrike O\nfrom O\nthe O\nedge O\nof O\nthe O\npenalty O\narea O\nto O\ngive O\nLeeds B-ORG\ntheir O\nfirst O\nwin O\nof O\nthe O\nseason O\non O\nMonday O\nand O\nleave O\nhapless O\nWimbledon B-ORG\nanchored O\nat O\nthe O\nbottom O\nof O\nthe O\nEngland B-LOC\npremier O\nleague O\n. O\n\nSharpe B-PER\nrepaid O\na O\nhuge O\nslice O\nof O\nthe O\n4.5 O\nmillion O\npound O\n( O\n$ O\n6.98 O\nmillion O\n) O\nfee O\nLeeds B-ORG\nhanded O\nManchester B-ORG\nUnited I-ORG\nfor O\nhis O\nservices O\nwith O\na O\ntop-draw O\nsecond-half O\ngoal O\nto O\nhand O\nWimbledon B-ORG\ntheir O\nthird O\nsuccessive O\ndefeat O\n. O\n\nIan B-PER\nRush I-PER\n, O\nthe O\nWelsh B-MISC\nstriker O\nsigned O\nfrom O\nLiverpool B-ORG\nin O\nthe O\nclose O\nseason O\n, O\nset O\nup O\nthe O\ngoal O\n, O\nfeeding O\nSharpe B-PER\nas O\nhe O\ngalloped O\nforward O\nand O\nthe O\nformer O\nEngland B-LOC\nwinger O\ncut O\ninside O\nonto O\nhis O\nunfavoured O\nright O\nfoot O\nto O\narc O\na O\nshot O\ninto O\nthe O\nright-hand O\ncorner O\nof O\nthe O\nnet O\n. O\n\nThe O\nonly O\ngoal O\nof O\nthe O\nmatch O\nalso O\nbrought O\nsome O\nrelief O\nfor O\nunder-fire O\nLeeds B-ORG\nmanager O\nHoward B-PER\nWilkinson I-PER\nfollowing O\nthe O\nteam O\n's O\npoor O\nstart O\nto O\nthe O\nseason O\n. O\n\nHome O\nfans O\nfrequently O\nbooed O\ntheir O\nown O\nside O\nuntil O\nSharpe B-PER\nturned O\nthe O\njeers O\nto O\ncheers O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nPREMIER O\nLEAGUE O\nSUMMARY O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nSummary O\nof O\nMonday O\n's O\nEnglish B-MISC\n\npremier O\nleague O\nsoccer O\nmatch O\n: O\n\nLeeds B-ORG\n1 O\n( O\nSharpe B-PER\n58th O\nminute O\n) O\nWimbledon B-ORG\n0 O\n. O\n\nHalftime O\n0-0 O\n. O\n\nAttendance O\n25,860 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nPREMIER O\nLEAGUE O\nRESULT O\n/ O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nResult O\nof O\nan O\nEnglish B-MISC\npremier O\n\nleague O\nsoccer O\nmatch O\non O\nMonday O\n: O\n\nLeeds B-ORG\n1 O\nWimbledon B-ORG\n0 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nSheffield B-ORG\nWednesday I-ORG\n3 O\n3 O\n0 O\n0 O\n6 O\n2 O\n9 O\n\nChelsea B-ORG\n3 O\n2 O\n1 O\n0 O\n3 O\n0 O\n7 O\n\nArsenal B-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n2 O\n6 O\n\nAston B-ORG\nVilla I-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n2 O\n6 O\n\nManchester B-ORG\nUnited I-ORG\n3 O\n1 O\n2 O\n0 O\n7 O\n4 O\n5 O\n\nSunderland B-ORG\n3 O\n1 O\n2 O\n0 O\n4 O\n1 O\n5 O\n\nLiverpool B-ORG\n3 O\n1 O\n2 O\n0 O\n5 O\n3 O\n5 O\n\nEverton B-ORG\n3 O\n1 O\n2 O\n0 O\n4 O\n2 O\n5 O\n\nTottenham B-ORG\n3 O\n1 O\n2 O\n0 O\n3 O\n1 O\n5 O\n\nNottingham B-ORG\nForest I-ORG\n3 O\n1 O\n1 O\n1 O\n5 O\n5 O\n4 O\n\nLeeds B-ORG\n3 O\n1 O\n1 O\n1 O\n4 O\n5 O\n4 O\n\nWest B-ORG\nHam I-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n4 O\n4 O\n\nLeicester B-ORG\n3 O\n1 O\n1 O\n1 O\n2 O\n3 O\n4 O\n\nNewcastle B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n4 O\n3 O\n\nMiddlesbrough B-ORG\n3 O\n0 O\n2 O\n1 O\n4 O\n5 O\n2 O\n\nDerby B-ORG\n3 O\n0 O\n2 O\n1 O\n4 O\n6 O\n2 O\n\nSouthampton B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n4 O\n1 O\n\nBlackburn B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n5 O\n1 O\n\nCoventry B-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n6 O\n1 O\n\nWimbledon B-ORG\n3 O\n0 O\n0 O\n3 O\n0 O\n6 O\n0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\n'S O\nWASIM B-PER\nAKRAM I-PER\nJOINS O\n300 O\nCLUB O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nWasim B-PER\nAkram I-PER\n's O\nthree-wicket O\nhaul O\n\nfor O\nPakistan B-LOC\nin O\nEngland B-LOC\n's O\nsecond O\ninnings O\nat O\nThe B-LOC\nOval I-LOC\non O\nMonday O\n\ngave O\nhim O\nhis O\n300th O\ntest O\nmatch O\nwicket O\n. O\n\nWasim B-PER\nbecomes O\nthe O\n11th O\nplayer O\nto O\njoin O\nthe O\n300-club O\nof O\n\nbowlers O\nand O\nthe O\nsecond O\nPakistani B-MISC\n, O\nafter O\nImran B-PER\nKhan I-PER\n, O\nto O\nachieve O\n\nthe O\nfeat O\n. O\n\nOther O\ncricketers O\nwho O\nhave O\ntaken O\nover O\n300 O\nTest O\nwickets O\n: O\n\nKapil B-PER\nDev I-PER\n( O\nIndia B-LOC\n) O\n434 O\nwickets O\n, O\n131 O\nTests O\n\nRichard B-PER\nHadlee I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n431 O\n, O\n86 O\n\nIan B-PER\nBotham I-PER\n( O\nEngland B-LOC\n) O\n383 O\n, O\n102 O\n\nMalcolm B-PER\nMarshall I-PER\n( O\nWest B-LOC\nIndies I-LOC\n) O\n376 O\n, O\n81 O\n\nImran B-PER\nKhan I-PER\n( O\nPakistan B-LOC\n) O\n362 O\n, O\n88 O\n\nDennis B-PER\nLillee I-PER\n( O\nAustralia B-LOC\n) O\n355 O\n, O\n70 O\n\nBob B-PER\nWillis I-PER\n( O\nEngland B-LOC\n) O\n325 O\n, O\n90 O\n\nLance B-PER\nGibbs I-PER\n( O\nWest B-LOC\nIndies I-LOC\n) O\n309 O\n, O\n79 O\n\nFred B-PER\nTrueman I-PER\n( O\nEngland B-LOC\n) O\n307 O\n, O\n67 O\n\nCourtney B-PER\nWalsh I-PER\n( O\nWest B-LOC\nIndies I-LOC\n) O\n309 O\n, O\n82 O\n\nWasim B-PER\nAkram I-PER\n( O\nPakistan B-LOC\n) O\n300 O\n, O\n70 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLISH B-MISC\nCOUNTY I-MISC\nCHAMPIONSHIP I-MISC\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nEnglish B-MISC\nCounty I-MISC\nChampionship I-MISC\n\ncricket O\nstandings O\nafter O\nMonday O\n's O\nmatches O\n( O\ntabulated O\nunder O\n\nplayed O\n, O\nwon O\n, O\nlost O\n, O\ndrawn O\n, O\nbatting O\nbonus O\npoints O\n, O\nbowling O\nbonus O\n\npoints O\n, O\ntotal O\npoints O\n) O\n: O\n\nEssex B-ORG\n13 O\n7 O\n2 O\n4 O\n45 O\n43 O\n212 O\n\nKent B-ORG\n14 O\n7 O\n1 O\n6 O\n42 O\n40 O\n212 O\n\nDerbyshire B-ORG\n13 O\n7 O\n2 O\n4 O\n41 O\n43 O\n208 O\n\nLeicestershire B-ORG\n13 O\n6 O\n1 O\n6 O\n43 O\n45 O\n202 O\n\nSurrey B-ORG\n13 O\n6 O\n1 O\n6 O\n37 O\n48 O\n199 O\n\nYorkshire B-ORG\n14 O\n6 O\n5 O\n3 O\n41 O\n46 O\n192 O\n\nWarwickshire B-ORG\n13 O\n6 O\n4 O\n3 O\n32 O\n43 O\n180 O\n\nMiddlesex B-ORG\n13 O\n5 O\n5 O\n3 O\n26 O\n45 O\n160 O\n\nSussex B-ORG\n13 O\n5 O\n6 O\n2 O\n27 O\n43 O\n156 O\n\nSomerset B-ORG\n13 O\n4 O\n5 O\n4 O\n27 O\n49 O\n152 O\n\nWorcestershire B-ORG\n13 O\n3 O\n3 O\n7 O\n33 O\n48 O\n150 O\n\nGlamorgan B-ORG\n13 O\n4 O\n5 O\n4 O\n36 O\n32 O\n144 O\n\nHampshire B-ORG\n13 O\n3 O\n5 O\n5 O\n28 O\n46 O\n137 O\n\nGloucestershire B-ORG\n14 O\n3 O\n6 O\n5 O\n19 O\n47 O\n129 O\n\nNorthamptonshire B-ORG\n13 O\n2 O\n6 O\n5 O\n30 O\n43 O\n120 O\n\nLancashire B-ORG\n13 O\n1 O\n4 O\n8 O\n38 O\n37 O\n115 O\n\nNottinghamshire B-ORG\n13 O\n1 O\n6 O\n6 O\n34 O\n40 O\n108 O\n\nDurham B-ORG\n14 O\n0 O\n9 O\n5 O\n22 O\n50 O\n87 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLISH B-MISC\nCOUNTY I-MISC\nCHAMPIONSHIP I-MISC\nRESULTS O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nResults O\non O\nthe O\nfinal O\nday O\nof O\n\nfour-day O\nEnglish B-MISC\nCounty I-MISC\nChampionship I-MISC\ncricket O\nmatches O\non O\nMonday O\n: O\n\nAt O\nColchester B-LOC\n: O\nEssex B-ORG\nbeat O\nGloucestershire B-ORG\nby O\nan O\ninnings O\nand O\n\n64 O\nruns O\n. O\n\nGloucestershire B-ORG\n280 O\nand O\n188 O\n( O\nJ. B-PER\nRussell I-PER\n57 O\n, O\nM. B-PER\nLynch I-PER\n50 O\n; O\n\nN. B-PER\nWilliams I-PER\n5-43 O\n) O\n. O\n\nEssex B-ORG\n532-8 O\ndeclared O\n( O\nG. B-PER\nGooch I-PER\n111 O\n, O\nR. B-PER\nIrani I-PER\n91 O\n, O\n\nP. B-PER\nPrichard I-PER\n88 O\n, O\nD. B-PER\nRobinson I-PER\n72 O\n; O\nM. B-PER\nAlleyne I-PER\n4-80 O\n) O\n. O\n\nEssex B-ORG\n24 O\npoints O\n, O\n\nGloucestershire B-ORG\n3 O\n. O\n\nAt O\nCardiff B-LOC\n: O\nMatch O\ndrawn O\n. O\n\nKent B-ORG\n323-5 O\ndeclared O\n( O\nC. B-PER\nHooper I-PER\n77 O\n, O\n\nD. B-PER\nFulton I-PER\n64 O\n, O\nN. B-PER\nLlong I-PER\n63 O\n, O\nM. B-PER\nWalker I-PER\n59 O\n) O\nand O\nsecond O\ninnings O\n\nforfeited O\n. O\n\nGlamorgan B-ORG\nfirst O\ninnings O\nforfeited O\nand O\n273-5 O\n( O\nH. B-PER\nMorris I-PER\n\n118 O\n, O\nA. B-PER\nCottey I-PER\n70 O\n) O\n. O\n\nGlamorgan B-ORG\n5 O\npoints O\n, O\nKent B-ORG\n6 O\n. O\n\nAt O\nNorthampton B-LOC\n: O\nNorthamptonshire B-ORG\nbeat O\nSussex B-ORG\nby O\n6 O\nwickets O\n. O\n\nSussex B-ORG\n389 O\nand O\n112 O\n. O\n\nNorthamptonshire B-ORG\n361 O\nand O\n142-4 O\n. O\n\nNorthamptonshire B-ORG\n24 O\npoints O\n, O\nSussex B-ORG\n8 O\n. O\n\nAt O\nTrent B-LOC\nBridge I-LOC\n: O\nMatch O\nabandoned O\nas O\na O\ndraw O\n- O\nrain O\n. O\n\nNottinghamshire B-ORG\n446-9 O\ndeclared O\nand O\n53-0 O\n. O\n\nSurrey B-ORG\n128-4 O\ndeclared O\n\n( O\nA. B-PER\nBrown I-PER\n56 O\nnot O\nout O\n) O\n. O\n\nNottinghamshire B-ORG\n8 O\npoints O\n, O\nSurrey B-ORG\n7 O\n. O\n\nAt O\nWorcester B-LOC\n: O\nMatch O\ndrawn O\n. O\n\nWarwickshire B-ORG\n310 O\nand O\n162-4 O\n\ndeclared O\n. O\n\nWorcestershire B-ORG\n205-9 O\ndeclared O\n( O\nK. B-PER\nSpiring I-PER\n52 O\n; O\nA. B-PER\nGiles I-PER\n\n3-12 O\n) O\nand O\n164-4 O\n( O\nP. B-PER\nWeston I-PER\n52 O\n) O\n. O\n\nWorcestershire B-ORG\n8 O\npoints O\n, O\n\nWarwickshire B-ORG\n10 O\n. O\n\nAt O\nHeadingley B-LOC\n: O\nMatch O\ndrawn O\n. O\n\nYorkshire B-ORG\n529-8 O\ndeclared O\n\n( O\nC. B-PER\nWhite I-PER\n181 O\n, O\nR. B-PER\nBlakey I-PER\n109 O\nnot O\nout O\n, O\nM. B-PER\nMoxon I-PER\n66 O\n, O\nM. B-PER\nVaughan I-PER\n57 O\n) O\n. O\n\nLancashire B-ORG\n323 O\n( O\nN. B-PER\nFairbrother I-PER\n86 O\n, O\nM. B-PER\nWatkinson I-PER\n64 O\n; O\nD. B-PER\nGough I-PER\n4-53 O\n) O\n\nand O\n231-7 O\n( O\nN. B-PER\nSpeak I-PER\n77 O\n, O\nN. B-PER\nFairbrother I-PER\n55 O\n; O\nD. B-PER\nGough I-PER\n4-48 O\n) O\n. O\n\nYorkshire B-ORG\n11 O\npoints O\n, O\nLancashire B-ORG\n8 O\n. O\n\nAt O\nLeicester B-LOC\n: O\nMatch O\ndrawn O\n. O\n\nLeicestershire B-ORG\n353 O\n. O\n\nHampshire B-ORG\n137 O\n\n( O\nG. B-PER\nParsons I-PER\n4-36 O\n) O\nand O\n135-9 O\n. O\n\nLeicestershire B-ORG\n11 O\npoints O\n, O\nHampshire B-ORG\n\n7. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\nBEAT O\nENGLAND B-LOC\nBY O\nNINE O\nWICKETS O\nIN O\nTHIRD O\nTEST O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nPakistan B-LOC\nbeat O\nEngland B-LOC\nby O\nnine O\nwickets O\non O\nthe O\nfifth O\nday O\nof O\nthe O\nthird O\nand O\nfinal O\ntest O\nat O\nThe B-LOC\nOval I-LOC\non O\nMonday O\nto O\nwin O\nthe O\nseries O\n2-0 O\n. O\n\nScores O\n: O\nEngland B-LOC\n326 O\nand O\n242 O\n; O\nPakistan B-LOC\n521-8 O\ndeclared O\nand O\n48-1 O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nV O\nPAKISTAN B-LOC\nFINAL O\nTEST O\nSCOREBOARD O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nScoreboard O\non O\nthe O\nlast O\nday O\nof O\nthe O\n\nthird O\nand O\nfinal O\ntest O\nbetween O\nEngland B-LOC\nand O\nPakistan B-LOC\nat O\nthe O\nOval B-LOC\non O\n\nMonday O\n: O\n\nEngland B-LOC\nfirst O\ninnings O\n326 O\n( O\nJ. B-PER\nCrawley I-PER\n106 O\n, O\nG. B-PER\nThorpe I-PER\n54 O\n; O\nWaqar B-PER\n\nYounis B-PER\n4-95 O\n) O\n\nPakistan B-LOC\nfirst O\ninnings O\n521-8 O\ndeclared O\n( O\nSaeed B-PER\nAnwar I-PER\n176 O\n, O\n\nSalim B-PER\nMalik I-PER\n100 O\nnot O\nout O\n, O\nIjaz B-PER\nAhmed I-PER\n61 O\n) O\n\nEngland B-LOC\nsecond O\ninnings O\n( O\novernight O\n74-0 O\n) O\n\nM. B-PER\nAtherton I-PER\nc O\nInzamam-ul-Haq B-PER\nb O\nMushtaq B-PER\nAhmed I-PER\n43 O\n\nA. B-PER\nStewart I-PER\nc O\nAsif B-PER\nMujtaba I-PER\nb O\nMushtaq B-PER\nAhmed I-PER\n54 O\n\nN. B-PER\nHussain I-PER\nlbw O\nb O\nMushtaq B-PER\nAhmed I-PER\n51 O\n\nG. B-PER\nThorpe I-PER\nc O\nWasim B-PER\nAkram I-PER\nb O\nMushtaq B-PER\nAhmed I-PER\n9 O\n\nJ. B-PER\nCrawley I-PER\nc O\nAamir B-PER\nSohail I-PER\nb O\nWasim B-PER\nAkram I-PER\n19 O\n\nN. B-PER\nKnight I-PER\nc O\nand O\nb O\nMushtaq B-PER\nAhmed I-PER\n8 O\n\nC. B-PER\nLewis I-PER\nlbw O\nb O\nWaqar B-PER\nYounis I-PER\n4 O\n\nD. B-PER\nCork I-PER\nb O\nMushtaq B-PER\nAhmed I-PER\n26 O\n\nR. B-PER\nCroft I-PER\nc O\nIjaz B-PER\nAhmed I-PER\nb O\nWasim B-PER\nAkram I-PER\n6 O\n\nI. B-PER\nSalisbury I-PER\nnot O\nout O\n0 O\n\nA. B-PER\nMullally I-PER\nb O\nWasim B-PER\nAkram I-PER\n0 O\n\nExtras O\n( O\nb-6 O\nlb-2 O\nw-1 O\nnb-13 O\n) O\n22 O\n\nTotal O\n242 O\n\nFall O\nof O\nwickets O\n: O\n1-96 O\n2-136 O\n3-166 O\n4-179 O\n5-187 O\n6-205 O\n7-220 O\n\n8-238 O\n9-242 O\n\nBowling O\n: O\nWasim B-PER\nAkram I-PER\n15.4-1-67-3 O\n, O\nWaqar B-PER\nYounis I-PER\n18-3-55-1 O\n, O\n\nMushtaq B-PER\nAhmed I-PER\n37-10-78-6 O\n, O\nAamir B-PER\nSohail I-PER\n2-1-4-0 O\n, O\nMohammad B-PER\nAkram I-PER\n\n10-3-30-0 O\n\nPakistan B-LOC\nsecond O\ninnings O\n\nSaeed B-PER\nAnwar I-PER\nc O\nKnight B-PER\nb O\nMullally B-PER\n1 O\n\nAamir B-PER\nSohail I-PER\nnot O\nout O\n29 O\n\nIjaz B-PER\nAhmed I-PER\nnot O\nout O\n13 O\n\nExtras O\n( O\nnb-5 O\n) O\n5 O\n\nTotal O\n( O\nfor O\none O\nwicket O\n) O\n48 O\n\nFall O\nof O\nwicket O\n: O\n1-7 O\n\nBowling O\n: O\nCork B-PER\n3-0-15-0 O\n, O\nMullally B-PER\n3-0-24-1 O\n, O\nCroft B-PER\n0.4-0-9-0 O\n\nResult O\n: O\nPakistan B-LOC\nwon O\nby O\n9 O\nwickets O\n\nFirst O\ntest O\n: O\nLord B-LOC\n's I-LOC\n- O\nPakistan B-LOC\nwon O\nby O\n164 O\nruns O\n\nSecond O\ntest O\n: O\nHeadingley B-LOC\n- O\nDrawn O\n\nPakistan B-LOC\nwin O\nseries O\n2-0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nPAKISTAN B-LOC\nNEED O\n48 O\nRUNS O\nTO O\nWIN O\nTHIRD O\nAND O\nFINAL O\nTEST O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nEngland B-LOC\nwere O\ndismissed O\nfor O\n242 O\nin O\ntheir O\nsecond O\ninnings O\non O\nthe O\nfifth O\nday O\nof O\nthe O\nthird O\nand O\nfinal O\ntest O\nat O\nThe B-LOC\nOval I-LOC\non O\nMonday O\nleaving O\nPakistan B-LOC\nrequiring O\n48 O\nruns O\nto O\nwin O\n. O\n\nPakistan B-LOC\nlead O\nthe O\nseries O\n1-0 O\n. O\n\n-DOCSTART- O\n\nRUGBY B-MISC\nLEAGUE I-MISC\n- O\nEUROPEAN B-MISC\nSUPER I-MISC\nLEAGUE I-MISC\nRESULT O\n/ O\nFINALS O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nResult O\nof O\na O\nEuropean B-MISC\nSuper I-MISC\nLeague I-MISC\n\nrugby O\nleague O\nmatch O\non O\nMonday O\n: O\n\nSt B-ORG\nHelens I-ORG\n66 O\nWarrington B-ORG\n14 O\n\nFinal O\nstandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\n\npoints O\nfor O\n, O\nagainst O\n, O\ntotal O\npoints O\n) O\n: O\n\nSt B-ORG\nHelens I-ORG\n22 O\n20 O\n0 O\n2 O\n950 O\n455 O\n40 O\n- O\nchampions O\n\nWigan B-ORG\n22 O\n19 O\n1 O\n2 O\n902 O\n326 O\n39 O\n\nBradford B-ORG\n22 O\n17 O\n0 O\n5 O\n767 O\n409 O\n34 O\n\nLondon B-ORG\n22 O\n12 O\n1 O\n9 O\n611 O\n462 O\n25 O\n\nWarrington B-ORG\n22 O\n12 O\n0 O\n10 O\n569 O\n565 O\n24 O\n\nHalifax B-ORG\n22 O\n10 O\n1 O\n11 O\n667 O\n576 O\n21 O\n\nSheffield B-ORG\n22 O\n10 O\n0 O\n12 O\n599 O\n730 O\n20 O\n\nOldham B-ORG\n22 O\n9 O\n1 O\n12 O\n473 O\n681 O\n19 O\n\nCastleford B-ORG\n22 O\n9 O\n0 O\n13 O\n548 O\n599 O\n18 O\n\nLeeds B-ORG\n22 O\n6 O\n0 O\n16 O\n555 O\n745 O\n12 O\n\nParis B-ORG\n22 O\n3 O\n1 O\n18 O\n398 O\n795 O\n7 O\n\nWorkington B-ORG\n22 O\n2 O\n1 O\n19 O\n325 O\n1021 O\n5 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nAND O\nSCOTTISH B-MISC\nLEAGUE O\nFIXTURES O\n- O\nAUG O\n30-SEPT O\n1 O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nEnglish B-MISC\nand O\nScottish B-MISC\nleague O\nsoccer O\n\nfixtures O\nfor O\nAugust O\n30 O\nto O\nSeptember O\n1 O\n: O\n\nFriday O\n, O\nAugust O\n30 O\n: O\n\nEnglish B-MISC\ndivision O\none O\n- O\nWest B-ORG\nBromwich I-ORG\nv O\nSheffield B-ORG\nUnited I-ORG\n. O\n\nEnglish B-MISC\ndivision O\nthree O\n- O\nSwansea B-ORG\nv O\nLincoln B-ORG\n. O\n\nSaturday O\n, O\nAugust O\n31 O\n: O\n\nEnglish B-MISC\ndivision O\none O\n- O\nBirmingham B-ORG\nv O\nBarnsley B-ORG\n, O\nBradford B-ORG\nv O\n\nTranmere B-ORG\n, O\nGrimsby B-ORG\nv O\nPortsmouth B-ORG\n, O\nHuddersfield B-ORG\nv O\nCrystal B-ORG\nPalace I-ORG\n, O\n\nManchester B-ORG\nCity I-ORG\nv O\nCharlton B-ORG\n, O\nNorwich B-ORG\nv O\nWolverhampton B-ORG\n, O\nOldham B-ORG\nv O\n\nIpswich B-ORG\n, O\nPort B-ORG\nVale I-ORG\nv O\nOxford B-ORG\n, O\nReading B-ORG\nv O\nStoke B-ORG\n, O\nSouthend B-ORG\nv O\n\nSwindon B-ORG\n. O\n\nEnglish B-MISC\ndivision O\ntwo O\n- O\nBlackpool B-ORG\nv O\nWycombe B-ORG\n, O\nBournemouth B-ORG\nv O\n\nPeterborough B-ORG\n, O\nBristol B-ORG\nRovers I-ORG\nv O\nStockport B-ORG\n, O\nBury B-ORG\nv O\nBristol B-ORG\nCity I-ORG\n, O\n\nCrewe B-ORG\nv O\nWatford B-ORG\n, O\nGillingham B-ORG\nv O\nChesterfield B-ORG\n, O\nLuton B-ORG\nv O\nRotherham B-ORG\n, O\n\nMillwall B-ORG\nv O\nBurnley B-ORG\n, O\nNotts B-ORG\nCounty I-ORG\nv O\nYork B-ORG\n, O\nPlymouth B-ORG\nv O\nPreston B-ORG\n, O\n\nShrewsbury B-ORG\nv O\nBrentford B-ORG\n, O\nWalsall B-ORG\nv O\nWrexham B-ORG\n. O\n\nEnglish B-MISC\ndivision O\nthree O\n- O\nBrighton B-ORG\nv O\nScunthorpe B-ORG\n, O\nCambridge B-ORG\nv O\n\nCardiff B-ORG\n, O\nColchester B-ORG\nv O\nHereford B-ORG\n, O\nDoncaster B-ORG\nv O\nDarlington B-ORG\n, O\nFulham B-ORG\nv O\n\nCarlisle B-ORG\n, O\nHull B-ORG\nv O\nBarnet B-ORG\n, O\nLeyton B-ORG\nOrient I-ORG\nv O\nHartlepool B-ORG\n, O\nMansfield B-ORG\nv O\n\nRochdale B-ORG\n, O\nScarborough B-ORG\nv O\nNorthampton B-ORG\n, O\nTorquay B-ORG\nv O\nExeter B-ORG\n, O\nWigan B-ORG\nv O\n\nChester B-ORG\n. O\n\nScottish B-MISC\ndivision O\none O\n- O\nEast B-ORG\nFife I-ORG\nv O\nClydebank B-ORG\n, O\nGreenock B-ORG\n\nMorton B-ORG\nv O\nFalkir B-ORG\n, O\nPartick B-ORG\nv O\nSt B-ORG\nMirren I-ORG\n, O\nSt B-ORG\nJohnstone I-ORG\nv O\n\nAirdrieonians B-ORG\n, O\nStirling B-ORG\nv O\nDundee B-ORG\n. O\n\nScottish B-MISC\ndivision O\ntwo O\n- O\nAyr B-ORG\nv O\nBerwick B-ORG\n, O\nClyde B-ORG\nv O\nQueen B-ORG\nof I-ORG\nthe I-ORG\n\nSouth B-ORG\n, O\nDumbarton B-ORG\nv O\nBrechin B-ORG\n, O\nLivingston B-ORG\nv O\nHamilton B-ORG\n, O\nStenhousemuir B-ORG\n\nv O\nStranraer B-ORG\n. O\n\nScottish B-MISC\ndivision O\nthree O\n- O\nAlbion B-ORG\nv O\nCowdenbeath B-ORG\n, O\nArbroath B-ORG\nv O\n\nEast B-ORG\nStirling I-ORG\n, O\nInverness B-ORG\nv O\nAlloa B-ORG\n, O\nMontrose B-ORG\nv O\nRoss B-ORG\nCounty I-ORG\n, O\n\nQueen B-ORG\n's I-ORG\nPark I-ORG\nv O\nForfar B-ORG\n. O\n\nSunday O\n, O\nSeptember O\n1 O\n: O\n\nEnglish B-MISC\ndivision O\none O\n- O\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\nv O\nBolton B-ORG\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nCOSTA B-LOC\nRICA I-LOC\nAND O\nCHILE B-LOC\nDRAW O\n1-1 O\nIN O\nFRIENDLY O\n. O\n\nLIBERIA B-LOC\n, O\nCosta B-LOC\nRica I-LOC\n1996-08-26 O\n\nCosta B-LOC\nRica I-LOC\nand O\nChile B-LOC\n\ndrew O\n1-1 O\n( O\nhalftime O\n1-0 O\n) O\nin O\na O\nfriendly O\nsoccer O\ninternational O\non O\n\nSunday O\n. O\n\nScorers O\n: O\n\nCosta B-LOC\nRica I-LOC\n- O\nRonaldo B-PER\nGonzalez I-PER\n( O\n10th O\nminute O\n, O\npenalty O\n\nChile B-LOC\n- O\nMarcelo B-PER\nSalas I-PER\n( O\n80th O\n) O\n\nAttendance O\n: O\n8,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSEYCHELLES B-LOC\nFAIL O\nIN O\nBID O\nFOR O\nHISTORIC O\nVICTORY O\n. O\n\nMark B-PER\nGleeson I-PER\n\nJOHANNESBURG B-LOC\n1996-08-26 O\n\nThe O\ntiny O\nislands O\nof O\nthe O\nSeychelles B-LOC\nfailed O\nto O\nmake O\nsoccer O\nhistory O\nat O\nthe O\nweekend O\nwhen O\nthey O\nbowed O\nout O\nof O\nthe O\npreliminary O\nrounds O\nof O\nthe O\nAfrican B-MISC\nNations I-MISC\nCup I-MISC\n. O\n\nTrailing O\nfellow O\nIndian B-LOC\nOcean I-LOC\nislanders O\nMauritius B-LOC\n1-0 O\nfrom O\nthe O\nfirst O\nleg O\n, O\nthey O\nwere O\nheld O\nto O\na O\n1-1 O\ndraw O\nat O\nhome O\non O\nSaturday O\ndespite O\nplaying O\nagainst O\n10 O\nmen O\nfor O\nmost O\nof O\nthe O\nmatch O\n. O\n\nThe O\n2-1 O\naggregate O\ntook O\nMauritius B-LOC\ninto O\nthe O\ngroup O\nphase O\nof O\nthe O\nqualifiers O\nfor O\nthe O\n1998 O\nfinals O\n, O\nand O\nkept O\nup O\nthe O\nSeychelles B-LOC\n' O\nrecord O\nof O\nnever O\nhaving O\nwon O\nan O\nofficial O\nmatch O\nin O\ntheir O\n10 O\nyears O\nof O\nFIFA B-ORG\nmembership O\n. O\n\nThe O\nSeychelles B-LOC\nmust O\nhave O\nthought O\nthey O\nwere O\non O\ncourse O\nfor O\na O\nhistoric O\nbreakthrough O\nwhen O\nMauritian B-MISC\nmidfielder O\nAndre B-PER\nCaboche I-PER\nwas O\nsent O\noff O\nfor O\na O\ncrude O\ntackle O\nin O\nthe O\n19th O\nminute O\n. O\n\nBut O\nthe O\nvisitors O\nresponded O\nto O\nthe O\nsetback O\nimmediately O\n-- O\nveteran O\nstriker O\nAshley B-PER\nMocude I-PER\nscoring O\na O\nminute O\nlater O\nto O\ngive O\nthem O\na O\ntwo-goal O\naggregate O\nlead O\n. O\n\nAlthough O\nDanny B-PER\nRose I-PER\n's O\n50th-minute O\nequaliser O\ngave O\nthe O\nSeychellois B-MISC\nrenewed O\nhope O\nthey O\ncould O\nnot O\nfind O\nthe O\nnet O\nagain O\nand O\nwere O\neliminated O\n. O\n\nMauritius B-LOC\nnow O\nplay O\nin O\ngroup O\nseven O\nof O\nthe O\nqualifiers O\nagainst O\nMalawi B-LOC\n, O\nMozambique B-LOC\nand O\nfavourites O\nZambia B-LOC\n. O\n\nNamibia B-LOC\n, O\nwho O\ndrew O\n0-0 O\nwith O\nBotswana B-LOC\nin O\ntheir O\nfirst O\nleg O\n, O\nwon O\nthe O\nsecond O\nleg O\nin O\nWindhoek B-LOC\n6-0 O\nto O\nstretch O\ntheir O\nunbeaten O\nrun O\nto O\neight O\nmatches O\nand O\ncontinue O\ntheir O\nremarkable O\nprogress O\non O\nthe O\nAfrican B-MISC\nsoccer O\nstage O\n. O\n\nThey O\nnow O\nplay O\nin O\ngroup O\nfive O\nwith O\nCameroon B-LOC\n, O\nGabon B-LOC\nand O\nKenya B-LOC\n. O\n\nGerman-based O\nstriker O\nBachirou B-PER\nSalou I-PER\nreturned O\nhome O\nto O\nTogo B-LOC\nto O\nscore O\nthe O\ndecisive O\nonly O\ngoal O\nof O\ntheir O\ntie O\nagainst O\nCongo B-LOC\n. O\n\nSalou B-PER\n, O\nwho O\nplays O\nfor O\nMSV B-ORG\nDuisburg I-ORG\nin O\nthe O\nBundesliga B-MISC\n, O\nscored O\nin O\nthe O\n53rd O\nminute O\nof O\nSunday O\n's O\nmatch O\nin O\nLome B-LOC\nfor O\na O\n1-0 O\naggregate O\nwin O\nwhich O\ntakes O\nhis O\nside O\ninto O\ngroup O\nsix O\n, O\nwhere O\nthey O\nwill O\nmeet O\nLiberia B-LOC\n, O\nTanzania B-LOC\nand O\nZaire B-LOC\n. O\n\nEthiopia B-LOC\nneeded O\na O\npenalty O\nshoot-out O\nin O\nAddis B-LOC\nAbaba I-LOC\nto O\novercome O\nUganda B-LOC\nafter O\na O\n2-2 O\naggregate O\nscoreline O\n. O\n\nBoth O\nlegs O\nended O\n1-1 O\nbefore O\nEthiopia B-LOC\nwon O\nthe O\nspot O\nkick O\ndecider O\n4-2 O\n. O\n\nUganda B-LOC\n's O\nelimination O\nfollows O\ntheir O\nhumiliating O\n5-1 O\naggregate O\ndefeat O\nby O\nAngola B-LOC\nin O\nJune O\n's O\nWorld B-MISC\nCup I-MISC\nqualifying O\npreliminaries O\n. O\n\nThe O\nother O\npreliminary O\nround O\nsecond O\nleg O\nmatch O\n, O\nbetween O\nMauritania B-LOC\nand O\nBenin B-LOC\nin O\nNouakchott B-LOC\n, O\nwas O\npostponed O\nuntil O\nFriday O\n. O\n\nBenin B-LOC\nwon O\nthe O\nfirst O\nleg O\n4-1 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nAFRICAN B-MISC\nNATIONS I-MISC\nCUP I-MISC\nCOLLATED O\nRESULTS O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-26 O\n\nCollated O\nresults O\nof O\nAfrican B-MISC\nNations I-MISC\nCup I-MISC\npreliminary O\nround O\n, O\nsecond O\nleg O\nmatches O\nplayed O\nat O\nthe O\nweekend O\n: O\n\nEthiopia B-LOC\n1 O\nUganda B-LOC\n1 O\n\n2-2 O\non O\naggregate O\n. O\n\nEthiopia B-LOC\nwin O\n4-2 O\non O\npenalties O\n\nMauritania B-LOC\nv O\nBenin B-LOC\npostponed O\nto O\nFriday O\n\nBenin B-LOC\nlead O\n4-1 O\nfrom O\nthe O\nfirst O\nleg O\n\nNamibia B-LOC\n6 O\nBotswana B-LOC\n0 O\n\nNamibia B-LOC\nwin O\n6-0 O\non O\naggregate O\n\nSeychelles B-LOC\n1 O\nMauritius B-LOC\n1 O\n\nMauritius B-LOC\nwin O\n2-1 O\non O\naggregate O\n\nTogo B-LOC\n1 O\nCongo B-LOC\n0 O\n\nTogo B-LOC\nwin O\n1-0 O\non O\naggregaete O\n\nCentral B-LOC\nAfrican I-LOC\nRepublic I-LOC\nwalkover O\nv O\nBurundi B-LOC\n\nWinners O\nprogress O\nto O\nqualifying O\ngroups O\nto O\nstart O\nin O\nOctober O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nUKRAINIAN B-MISC\nPREMIER O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nKIEV B-LOC\n1996-08-26 O\n\nResults O\nof O\nUkraine B-LOC\npremier O\ndivision O\n\nmatches O\nplayed O\nat O\nthe O\nweekend O\n: O\n\nDynamo B-ORG\nKiev I-ORG\n5 O\nKremin B-ORG\nKremenchuk I-ORG\n0 O\n\nVorskla B-ORG\nPoltava I-ORG\n2 O\nNyva B-ORG\nTernopil I-ORG\n1 O\n\nTorpedo B-ORG\nZaporizhya I-ORG\n2 O\nShakhtar B-ORG\nDonetsk I-ORG\n1 O\n\nKryvbas B-ORG\nKryvy I-ORG\nRig I-ORG\n1 O\nKarpaty B-ORG\nLviv I-ORG\n2 O\n\nPrykarpattya B-ORG\nIvano-Frankivsk I-ORG\n0 O\nZirka-Nibas B-ORG\nKirovohrad I-ORG\n0 O\n\nChornomorets B-ORG\nOdessa I-ORG\n2 O\nMetalurg B-ORG\nZaporizhya I-ORG\n1 O\n\nDnipro B-ORG\nDnipropetrovsk I-ORG\n2 O\nCSKA B-ORG\nKiev I-ORG\n1 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nDynamo B-ORG\n6 O\n5 O\n0 O\n1 O\n16 O\n2 O\n15 O\n\nVorskla B-ORG\n6 O\n4 O\n2 O\n0 O\n11 O\n3 O\n14 O\n\nDnipro B-ORG\n6 O\n4 O\n1 O\n1 O\n13 O\n6 O\n13 O\n\nChornomorets B-ORG\n6 O\n4 O\n1 O\n1 O\n11 O\n7 O\n13 O\n\nShakhtar B-ORG\n6 O\n3 O\n2 O\n1 O\n10 O\n3 O\n11 O\n\nMetalurg B-ORG\n6 O\n3 O\n2 O\n1 O\n9 O\n6 O\n11 O\n\nKarpaty B-ORG\n6 O\n3 O\n1 O\n2 O\n9 O\n5 O\n10 O\n\nZirka-Nibas B-ORG\n6 O\n3 O\n1 O\n2 O\n6 O\n8 O\n10 O\n\nTorpedo B-ORG\n6 O\n3 O\n1 O\n2 O\n8 O\n7 O\n10 O\n\nTavria B-ORG\n5 O\n2 O\n0 O\n3 O\n3 O\n7 O\n6 O\n\nNyva B-ORG\nTernopil I-ORG\n6 O\n2 O\n0 O\n4 O\n4 O\n11 O\n6 O\n\nCSKA B-ORG\n6 O\n1 O\n1 O\n4 O\n4 O\n7 O\n4 O\n\nKryvbas B-ORG\n6 O\n1 O\n1 O\n4 O\n5 O\n9 O\n4 O\n\nNyva B-ORG\nVinnytsya I-ORG\n5 O\n0 O\n2 O\n3 O\n1 O\n7 O\n2 O\n\nPrykarpattya B-ORG\n6 O\n0 O\n2 O\n4 O\n4 O\n13 O\n2 O\n\nKremin B-ORG\n6 O\n0 O\n1 O\n5 O\n1 O\n14 O\n1 O\n\n-DOCSTART- O\n\nSWIMMING O\n- O\nPOPOV B-PER\nIN O\n`SERIOUS O\nCONDITION O\n' O\nAFTER O\nSTABBING O\n. O\n\nMOSCOW B-LOC\n1996-08-26 O\n\nRussian B-MISC\ndouble O\nOlympic B-MISC\nswimming O\nchampion O\nAlexander B-PER\nPopov I-PER\nwas O\nin O\na O\nserious O\ncondition O\non O\nMonday O\nafter O\nbeing O\nstabbed O\non O\na O\nMoscow B-LOC\nstreet O\n. O\n\nA O\ndoctor O\nsaid O\nit O\nwas O\ntoo O\nearly O\nto O\nsay O\nwhether O\nPopov B-PER\n, O\nthe O\nonly O\nman O\nto O\nretain O\nthe O\nOlympic B-MISC\n50 O\nand O\n100 O\nmetres O\nfreestyle O\ntitles O\n, O\nwould O\nreturn O\nto O\ntop-level O\nsport O\n. O\n\n\" O\nHis O\ncondition O\nis O\nserious O\n, O\n\" O\nsaid O\nRimma B-PER\nMaslova I-PER\n, O\ndeputy O\nchief O\ndoctor O\nof O\nHospital B-LOC\nNo I-LOC\n31 I-LOC\nin O\nthe O\nRussian B-MISC\ncapital O\n. O\n\" O\n\nBut O\nhe O\nis O\nconscious O\nand O\nis O\ntalking O\nand O\nsmiling O\n. O\n\" O\n\nMaslova B-PER\ntold O\nReuters B-ORG\nshe O\nwas O\nnot O\nan O\nexpert O\nin O\nsports O\nmedicine O\n, O\nbut O\nsaid O\nit O\nwas O\ntoo O\nearly O\nto O\njudge O\nPopov B-PER\n's O\nchances O\nof O\nreturning O\nto O\ncompetitive O\nswimming O\n. O\n\nPopov B-PER\n, O\nwho O\nwon O\ngold O\nin O\nthe O\n50 O\nand O\n100 O\nmetres O\nfreestyle O\nat O\nthe O\nrecent O\nAtlanta B-MISC\nOlympics I-MISC\n, O\nwas O\nstabbed O\nin O\nthe O\nabdomen O\nlate O\non O\nSaturday O\nafter O\nan O\nargument O\nwith O\na O\ngroup O\nof O\nroadside O\nwatermelon O\nsellers O\nin O\nsouth-west O\nMoscow B-LOC\n. O\n\nMaslova B-PER\nsaid O\nthe O\nwound O\nhad O\naffected O\na O\nlung O\nand O\na O\nkidney O\n. O\n\nDoctors O\noperated O\non O\nPopov B-PER\n, O\n24 O\n, O\nfor O\nthree O\nhours O\n. O\n\nPopov B-PER\ntold O\nNTV B-ORG\ntelevision O\non O\nSunday O\nhe O\nwas O\nin O\nno O\ndanger O\nand O\npromised O\nhe O\nwould O\nbe O\nback O\nin O\nthe O\npool O\nshortly O\n. O\n\" O\n\nThere O\n's O\nno O\nneed O\nto O\nworry O\n. O\n\nWe O\n're O\ngoing O\nto O\nbe O\nwalking O\nsoon O\n-- O\nand O\nswimming O\n, O\n\" O\nhe O\ninsisted O\ncheerfully O\nfrom O\nhis O\nbed O\nin O\nthe O\nintensive O\ncare O\nunit O\n. O\n\nInterfax B-ORG\nnews O\nagency O\nsaid O\npolice O\nhad O\ndetained O\none O\nof O\nthe O\nattackers O\n. O\n\nIt O\nsaid O\nthe O\nrow O\nstarted O\nwhen O\nPopov B-PER\nand O\na O\ngroup O\nof O\nhis O\nfriends O\nwere O\nreturning O\nfrom O\na O\nparty O\n. O\n\nVitaly B-PER\nSmirnov I-PER\n, O\npresident O\nof O\nthe O\nRussian B-MISC\nNational I-MISC\nOlympic I-MISC\nCommittee I-MISC\n, O\nsaid O\nPresident O\nBoris B-PER\nYeltsin I-PER\nhad O\ngiven O\nthe O\nswimmer O\nRussia B-LOC\n's O\ntop O\naward O\nfor O\nhis O\nOlympic B-MISC\nperformance O\n. O\n\" O\n\nI O\nam O\nnot O\na O\ndoctor O\nbut O\nI O\nthink O\nhe O\nis O\ndoing O\nall O\nright O\n, O\n\" O\nsaid O\nSmirnov B-PER\n. O\n\nSmirnov B-PER\nsaid O\nthe O\nOlympic B-MISC\nCommittee I-MISC\nmight O\nask O\nthe O\ngovernment O\nto O\ntake O\nmeasures O\nto O\nprotect O\nthe O\ncountry O\n's O\nbest O\nathletes O\n, O\nsome O\nof O\nwhom O\nhave O\nalready O\nchosen O\nto O\nlive O\nabroad O\nfor O\nfear O\nof O\na O\nsurge O\nin O\ncrime O\nin O\npost-Soviet B-MISC\nRussia B-LOC\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSLOVAK B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nBRATISLAVA B-LOC\n1996-08-26 O\n\nResults O\nof O\nSlovak B-MISC\nfirst O\n\ndivision O\nsoccer O\nmatches O\nat O\nthe O\nweekend O\n: O\n\nInter B-ORG\nBratislava I-ORG\n0 O\nSlovan B-ORG\nBratislava I-ORG\n2 O\n\nChemlon B-ORG\nHumenne I-ORG\n0 O\nTatran B-ORG\nPresov I-ORG\n1 O\n\nArtmedia B-ORG\nPetrzalka I-ORG\n0 O\nJAS B-ORG\nBardejov I-ORG\n0 O\n\nDAC B-ORG\nDunajska I-ORG\nStreda I-ORG\n1 O\nSpartak B-ORG\nTrnava I-ORG\n3 O\n\nDukla B-ORG\nBanska I-ORG\nBystrica I-ORG\n3 O\nFC B-ORG\nNitra I-ORG\n0 O\n\nMSK B-ORG\nZilina I-ORG\n0 O\nFC B-ORG\nKosice I-ORG\n2 O\n\nPetrimex B-ORG\nPrievidza I-ORG\n2 O\nFC B-ORG\nRimavska I-ORG\nSobota I-ORG\n0 O\n\nLokomotiva B-ORG\nKosice I-ORG\n2 O\nKerametal B-ORG\nDubnica I-ORG\n0 O\n\nStandings O\n( O\ntabulate O\nunder O\ngames O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\n\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nTatran B-ORG\nPresov I-ORG\n4 O\n3 O\n1 O\n0 O\n5 O\n0 O\n10 O\n\nDukla B-ORG\nBanska I-ORG\nBystrica I-ORG\n4 O\n3 O\n0 O\n1 O\n7 O\n2 O\n9 O\n\nSlovan B-ORG\nBratislava I-ORG\n4 O\n3 O\n0 O\n1 O\n7 O\n2 O\n9 O\n\nPetrimex B-ORG\nPrievidza I-ORG\n4 O\n3 O\n0 O\n1 O\n4 O\n2 O\n9 O\n\nSpartak B-ORG\nTrnava I-ORG\n4 O\n2 O\n2 O\n0 O\n10 O\n5 O\n8 O\n\nFC B-ORG\nKosice I-ORG\n4 O\n2 O\n2 O\n0 O\n6 O\n3 O\n8 O\n\nArtmedia B-ORG\nPetrzalka I-ORG\n4 O\n1 O\n3 O\n0 O\n1 O\n0 O\n6 O\n\nDAC B-ORG\nDunajska I-ORG\nStreda I-ORG\n4 O\n2 O\n0 O\n2 O\n5 O\n6 O\n6 O\n\nFC B-ORG\nRimavska I-ORG\nSobota I-ORG\n4 O\n2 O\n0 O\n2 O\n4 O\n5 O\n6 O\n\nJAS B-ORG\nBardejov I-ORG\n4 O\n1 O\n2 O\n1 O\n2 O\n2 O\n5 O\n\nChemlon B-ORG\nHumenne I-ORG\n4 O\n1 O\n1 O\n2 O\n1 O\n2 O\n4 O\n\nInter B-ORG\nBratislava I-ORG\n4 O\n1 O\n1 O\n2 O\n4 O\n6 O\n4 O\n\nLokomotiva B-ORG\nKosice I-ORG\n4 O\n1 O\n1 O\n2 O\n3 O\n5 O\n4 O\n\nKerametal B-ORG\nDubnica I-ORG\n4 O\n0 O\n1 O\n3 O\n3 O\n9 O\n1 O\n\nFC B-ORG\nNitra I-ORG\n4 O\n0 O\n0 O\n4 O\n1 O\n8 O\n0 O\n\nMSK B-ORG\nZilina I-ORG\n4 O\n0 O\n0 O\n4 O\n0 O\n6 O\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nHUNGARY B-LOC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nBUDAPEST B-LOC\n1996-08-26 O\n\nHungarian B-MISC\nfirst O\ndivision O\n\nsoccer O\nresults O\nand O\nstandings O\nfrom O\nweekend O\nand O\nbank O\nholiday O\n: O\n\nStadler B-ORG\n0 O\nHaladas B-ORG\n0 O\n\nMTK B-ORG\n3 O\nFerencvaros B-ORG\n0 O\n\nBekescsaba B-ORG\n0 O\nBVSC B-ORG\n1 O\n\nCsepel B-ORG\n1 O\nVideoton(* B-ORG\n) O\n1 O\n\nZTE B-ORG\n1 O\nDebrecen B-ORG\n5 O\n\nSiofok B-ORG\n0 O\nUjpest B-ORG\n2 O\n\nVac B-ORG\n0 O\nVasas B-ORG\n1 O\n\nKispest B-ORG\n3 O\nPecs B-ORG\n1 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\n1. O\nUjpest B-ORG\nTE I-ORG\n3 O\n3 O\n- O\n- O\n10 O\n2 O\n9 O\n\n2. O\nMTK B-ORG\n3 O\n3 O\n- O\n- O\n7 O\n1 O\n9 O\n\n3. O\nBVSC B-ORG\n3 O\n2 O\n1 O\n- O\n6 O\n2 O\n7 O\n\n4. O\nDebrecen B-ORG\n3 O\n2 O\n- O\n1 O\n10 O\n4 O\n6 O\n\n5. O\nBekescsaba B-ORG\n3 O\n2 O\n- O\n1 O\n6 O\n2 O\n6 O\n\n6. O\nFTC B-ORG\n3 O\n2 O\n- O\n1 O\n8 O\n7 O\n6 O\n\n7. O\nHaladas B-ORG\n3 O\n1 O\n2 O\n- O\n2 O\n1 O\n5 O\n\n8. O\nVideoton B-ORG\n3 O\n1 O\n1 O\n1 O\n7 O\n5 O\n4 O\n\n9. O\nVasas B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n3 O\n4 O\n\n10. O\nKispest B-ORG\n3 O\n1 O\n1 O\n1 O\n6 O\n7 O\n4 O\n\n11. O\nGyor B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n5 O\n4 O\n\n12. O\nCsepel B-ORG\n3 O\n- O\n3 O\n- O\n3 O\n3 O\n3 O\n\n13. O\nPecs B-ORG\n3 O\n1 O\n- O\n2 O\n3 O\n5 O\n3 O\n\n14. O\nZTE B-ORG\n3 O\n1 O\n- O\n2 O\n3 O\n10 O\n3 O\n\n15. O\nStadler B-ORG\nFC O\n3 O\n- O\n1 O\n2 O\n2 O\n6 O\n1 O\n\n16. O\nIII.ker.TVE B-ORG\n3 O\n- O\n1 O\n2 O\n2 O\n7 O\n1 O\n\n17. O\nSiofok B-ORG\n3 O\n- O\n- O\n3 O\n2 O\n7 O\n0 O\n\n18. O\nVac B-ORG\n3 O\n- O\n- O\n3 O\n2 O\n8 O\n0 O\n\n*Name O\nof O\nParmalat B-ORG\n/ I-ORG\nFehervar I-ORG\nFC I-ORG\nhas O\nbeen O\nchanged O\nto O\nVideoton B-ORG\n. O\n\n-- O\nBudapest B-LOC\nnewsroom O\n, O\n+361 O\n266 O\n2410 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nCZECH B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nPRAGUE B-LOC\n1996-08-26 O\n\nResults O\nof O\nthe O\nCzech B-LOC\nRepublic I-LOC\n's O\n\nfirst O\ndivision O\nsoccer O\nmatches O\nat O\nthe O\nweekend O\n: O\n\nPetra B-ORG\nDrnovice I-ORG\n1 O\nSlovan B-ORG\nLiberec I-ORG\n3 O\n\nSK B-ORG\nSlavia I-ORG\nPraha I-ORG\n3 O\nSK B-ORG\nCeske I-ORG\nBudejovice I-ORG\n0 O\n\nFK B-ORG\nJablonec I-ORG\n3 O\nViktoria B-ORG\nZizkov I-ORG\n1 O\n\nBanik B-ORG\nOstrava I-ORG\n3 O\nFK B-ORG\nTeplice I-ORG\n1 O\n\nBoby B-ORG\nBrno I-ORG\n1 O\nSigma B-ORG\nOlomouc I-ORG\n0 O\n\nFC B-ORG\nBohemians I-ORG\n0 O\nFC B-ORG\nKarvina I-ORG\n2 O\n\nSK B-ORG\nHradec I-ORG\nKralove I-ORG\n0 O\nKaucuk B-ORG\nOpava I-ORG\n0 O\n\nPlaying O\nMonday O\n: O\nViktoria B-ORG\nPlzen I-ORG\nv O\nAC B-ORG\nSparta I-ORG\nPraha I-ORG\n\nStandings O\n( O\ntabulate O\nunder O\ngames O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\n\ngoals O\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nBoby B-ORG\nBrno I-ORG\n3 O\n3 O\n0 O\n0 O\n5 O\n2 O\n9 O\n\nBanik B-ORG\nOstrava I-ORG\n3 O\n2 O\n0 O\n1 O\n7 O\n3 O\n6 O\n\nFK B-ORG\nJablonec I-ORG\n3 O\n2 O\n0 O\n1 O\n5 O\n2 O\n6 O\n\nSK B-ORG\nSlavia I-ORG\nPraha I-ORG\n3 O\n1 O\n2 O\n0 O\n6 O\n3 O\n5 O\n\nKaucuk B-ORG\nOpava I-ORG\n3 O\n1 O\n2 O\n0 O\n2 O\n1 O\n5 O\n\nSigma B-ORG\nOlomouc I-ORG\n3 O\n1 O\n1 O\n1 O\n6 O\n3 O\n4 O\n\nPetra B-ORG\nDrnovice I-ORG\n3 O\n1 O\n1 O\n1 O\n7 O\n5 O\n4 O\n\nSlovan B-ORG\nLiberec I-ORG\n3 O\n1 O\n1 O\n1 O\n5 O\n4 O\n4 O\n\nFK B-ORG\nTeplice I-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n4 O\n4 O\n\nFC B-ORG\nKarvina I-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n5 O\n4 O\n\nSK B-ORG\nCeske I-ORG\nBudejovice I-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n5 O\n4 O\n\nViktoria B-ORG\nPlzen I-ORG\n2 O\n0 O\n2 O\n0 O\n2 O\n2 O\n2 O\n\nAC B-ORG\nSparta I-ORG\nPraha I-ORG\n2 O\n0 O\n1 O\n1 O\n3 O\n4 O\n1 O\n\nFC B-ORG\nBohemians I-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n4 O\n1 O\n\nViktoria B-ORG\nZizkov I-ORG\n3 O\n0 O\n1 O\n2 O\n3 O\n8 O\n1 O\n\nSK B-ORG\nHradec I-ORG\nKralove I-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n7 O\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nMEXICAN B-MISC\nCHAMPIONSHIP O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nMEXICO B-LOC\nCITY I-LOC\n1996-08-26 O\n\nResults O\nof O\nweekend O\nmatches O\n\nin O\nthe O\nMexican B-MISC\nsoccer O\nchampionship O\n: O\n\nAtlante B-ORG\n1 O\nAtlas B-ORG\n1 O\n\nCruz B-ORG\nAzul I-ORG\n2 O\nLeon B-ORG\n2 O\n\nGuadalajara B-ORG\n5 O\nAmerica B-ORG\n0 O\n\nMonterrey B-ORG\n2 O\nVeracruz B-ORG\n1 O\n\nPachuca B-ORG\n3 O\nToluca B-ORG\n0 O\n\nPuebla B-ORG\n2 O\nUNAM B-ORG\n1 O\n\nSantos B-ORG\n2 O\nMorelia B-ORG\n1 O\n\nUAG B-ORG\n1 O\nNeza B-ORG\n2 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n\nGroup O\n1 O\n\nPuebla B-ORG\n3 O\n3 O\n0 O\n0 O\n7 O\n2 O\n9 O\n\nCruz B-ORG\nAzul I-ORG\n3 O\n2 O\n1 O\n0 O\n7 O\n3 O\n7 O\n\nAtlante B-ORG\n3 O\n2 O\n1 O\n0 O\n6 O\n2 O\n7 O\n\nNeza B-ORG\n3 O\n1 O\n0 O\n2 O\n2 O\n7 O\n3 O\n\nVeracruz B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n6 O\n1 O\n\nGroup O\n2 O\n\nNecaxa B-ORG\n3 O\n1 O\n1 O\n1 O\n6 O\n4 O\n4 O\n\nPachuca B-ORG\n3 O\n1 O\n1 O\n1 O\n6 O\n7 O\n4 O\n\nLeon B-ORG\n3 O\n0 O\n3 O\n0 O\n3 O\n3 O\n3 O\n\nAmerica B-ORG\n3 O\n1 O\n0 O\n2 O\n5 O\n7 O\n3 O\n\nMorelia B-ORG\n3 O\n0 O\n1 O\n2 O\n3 O\n8 O\n1 O\n\nGroup O\n3 O\n\nAtlas B-ORG\n3 O\n2 O\n1 O\n0 O\n7 O\n2 O\n7 O\n\nGuadalajara B-ORG\n3 O\n2 O\n1 O\n0 O\n7 O\n0 O\n7 O\n\nToluca B-ORG\n3 O\n1 O\n0 O\n2 O\n6 O\n5 O\n3 O\n\nUNAM B-ORG\n3 O\n0 O\n0 O\n3 O\n2 O\n6 O\n0 O\n\nGroup O\n4 O\n\nSantos B-ORG\n3 O\n3 O\n0 O\n0 O\n4 O\n1 O\n9 O\n\nMonterrey B-ORG\n4 O\n1 O\n1 O\n2 O\n2 O\n5 O\n4 O\n\nCelaya B-ORG\n2 O\n0 O\n2 O\n0 O\n1 O\n1 O\n2 O\n\nUAG B-ORG\n3 O\n0 O\n0 O\n3 O\n1 O\n8 O\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPLAYERS O\nLEAVE O\nMATCH O\nEARLY O\nTO O\nCATCH O\nPLANE O\n. O\n\nBrian B-PER\nHomewood I-PER\n\nRIO B-LOC\nDE I-LOC\nJANEIRO I-LOC\n1996-08-26 O\n\nTwo O\nkey O\nplayers O\nleft O\na O\nBrazilian B-MISC\nchampionship O\nmatch O\nearly O\non O\nSunday O\nbecause O\nthey O\nhad O\nto O\ncatch O\na O\nplane O\nto O\nRussia B-LOC\nto O\nplay O\nwith O\nthe O\nnational O\nteam O\n. O\n\nSao B-ORG\nPaulo I-ORG\nmidfielder O\nAndre B-PER\nand O\nSantos B-ORG\ndefender O\nNarciso B-PER\nwere O\nboth O\nsubstituted O\nduring O\ntheir O\nteams O\n' O\ngame O\n, O\ntaken O\nto O\nSao B-LOC\nPaulo I-LOC\nairport O\nand O\nflown O\nto O\nRio B-LOC\nde I-LOC\nJaneiro I-LOC\nin O\na O\nprivate O\njet O\nchartered O\nby O\nthe O\nBrazilian B-MISC\nFootball I-MISC\nConfederation I-MISC\n( O\nCBF B-MISC\n) O\n. O\n\nAt O\nRio B-LOC\n, O\nthey O\njoined O\nup O\nwith O\nthe O\nnational O\nteam O\nsquad O\nfor O\nthe O\njourney O\nto O\nMoscow B-LOC\n, O\nwhere O\nBrazil B-LOC\nwill O\nface O\nRussia B-LOC\nin O\na O\nfriendly O\ninternational O\non O\nWednesday O\n. O\n\nThe O\nproblem O\narose O\nbecause O\nthe O\nSao B-ORG\nPaulo-Santos I-ORG\nclash O\nwas O\nselected O\nas O\nthe O\nday O\n's O\ntelevised O\nlive O\nmatch O\n, O\nforcing O\nit O\nto O\nbe O\nput O\nback O\nthree O\nhours O\nfrom O\nthe O\nusual O\nkickoff O\ntime O\n. O\n\nSantos B-ORG\nsuffered O\nmore O\nfrom O\ntheir O\nloss O\nas O\nNarciso B-PER\n's O\nreplacement O\nJean B-PER\ngave O\naway O\na O\npenalty O\nfrom O\nwhich O\nSao B-ORG\nPaulo I-ORG\nscored O\nthe O\ndecisive O\ngoal O\nin O\na O\n2-1 O\nwin O\n. O\n\nSao B-ORG\nPaulo I-ORG\nlead O\nthe O\nfirst O\nstage O\nof O\nthe O\nchampionship O\non O\ngoal O\ndifference O\nfrom O\nsurprise O\npackage O\nJuventude B-ORG\n, O\nwho O\nbeat O\nInternacional B-ORG\n2-1 O\n. O\n\nCorinthians B-ORG\n, O\nwho O\nplayed O\nin O\na O\ntournament O\nin O\nSpain B-LOC\nlast O\nweek O\n, O\nalso O\nfaced O\na O\nplane O\nmarathon O\nas O\nthey O\nattempted O\nto O\nkeep O\nup O\nwith O\na O\nhectic O\nfixture O\nlist O\n. O\n\nThey O\nwere O\ndue O\nto O\nleave O\nSpain B-LOC\nMonday O\nnight O\n, O\narrive O\nin O\nSao B-LOC\nPaulo I-LOC\non O\nTuesday O\nmorning O\n, O\ncatch O\nanother O\nplane O\nto O\nthe O\nsouthern O\ncity O\nof O\nCuritiba B-LOC\none O\nhour O\nlater O\nand O\nthen O\nplay O\naway O\nto O\nAtletico B-ORG\nParanaense I-ORG\nin O\nthe O\nBrazilian B-MISC\nchampionship O\nthe O\nsame O\nevening O\n. O\n\nBotafogo B-ORG\nstriker O\nTulio B-PER\n, O\nwho O\nwas O\noverlooked O\nby O\nZagalo B-PER\nfor O\nthe O\ntour O\nwhich O\nalso O\nfeatures O\na O\ngame O\naway O\nto O\nthe O\nNetherlands B-LOC\non O\nSunday O\n, O\nscored O\nhis O\nthird O\ngoal O\nin O\nthree O\ngames O\nas O\nthe O\ndefending O\nchampions O\nbeat O\nBahia B-ORG\n2-1 O\naway O\n. O\n\nTulio B-PER\n, O\nwho O\nhas O\nbeen O\ntop-scorer O\nin O\nthe O\ncompetition O\nfor O\nthe O\nlast O\ntwo O\nseasons O\n, O\nhas O\nbeen O\nstruggling O\nagainst O\ninjury O\nfor O\nmost O\nof O\nthis O\nyear O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nARGENTINE B-MISC\nCHAMPIONSHIP O\nRESULTS O\n. O\n\nBUENOS B-LOC\nAIRES I-LOC\n1996-08-26 O\n\nResults O\nof O\nmatches O\non O\nthe O\n\nopening O\nweekend O\nof O\nthe O\nArgentine B-MISC\nApertura I-MISC\nchampionship O\n: O\n\nEstudiantes B-ORG\n2 O\nBoca B-ORG\nJuniors I-ORG\n3 O\n\nFerro B-ORG\nCarril I-ORG\nOeste I-ORG\n0 O\nIndependiente B-ORG\n3 O\n\nGimnasia-Jujuy B-ORG\n1 O\nPlatense B-ORG\n0 O\n\nHuracan B-ORG\n0 O\nLanus B-ORG\n0 O\n\nHuracan-Corrientes B-ORG\n3 O\nUnion B-ORG\n6 O\n\nNewell B-ORG\n's I-ORG\nOld I-ORG\nBoys I-ORG\n0 O\nVelez B-ORG\nSarsfield I-ORG\n2 O\n\nRacing B-ORG\nClub I-ORG\n0 O\nRosario B-ORG\nCentral I-ORG\n2 O\n\nRiver B-ORG\nPlate I-ORG\n0 O\nGimnasia-La B-ORG\nPlata I-ORG\n0 O\n\nSan B-ORG\nLorenzo I-ORG\n0 O\nBanfield B-ORG\n1 O\n\nPlaying O\nMonday O\n: O\nDeportivo B-ORG\nEspanol I-ORG\nv O\nColon B-ORG\n\nNote O\n: O\nthe O\nApertura B-MISC\nis O\nthe O\nfirst O\nof O\ntwo O\nchampionships O\nplayed O\n\nin O\nthe O\nArgentine B-MISC\nseason O\n. O\n\nThe O\nteams O\nmeet O\neach O\nother O\nonce O\nin O\neach O\n\ntournament O\n. O\n\nThere O\nis O\nno O\noverall O\nchampion O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nHONDURAS B-LOC\nBEAT O\nCUBA B-LOC\n4-0 O\nIN O\nFRIENDLY O\n. O\n\nTEGUCIGALPA B-LOC\n1996-08-26 O\n\nHonduras B-LOC\nbeat O\nCuba B-LOC\n4-0 O\n\n( O\nhalftime O\n3-0 O\n) O\nin O\na O\nfriendly O\nsoccer O\ninternational O\non O\nSunday O\n. O\n\nScorers O\n: O\nJuan B-PER\nCastro I-PER\n( O\n3rd O\nminute O\n) O\n, O\nEnrique B-PER\nCenteno I-PER\n( O\n33rd O\nand O\n\n84th O\n) O\n, O\nCarlos B-PER\nPavon I-PER\n( O\n37th O\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBRAZILIAN B-MISC\nCHAMPIONSHIP O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nRIO B-LOC\nDE I-LOC\nJANEIRO I-LOC\n1996-08-26 O\n\nResults O\nof O\nBrazilian B-MISC\n\nsoccer O\nchampionship O\nmatches O\nplayed O\nat O\nthe O\nweekend O\n. O\n\nBahia B-ORG\n1 O\nBotafogo B-ORG\n2 O\n\nBragantino B-ORG\n1 O\nVasco B-ORG\nda I-ORG\nGama I-ORG\n2 O\n\nCricuma B-ORG\n4 O\nFluminense B-ORG\n1 O\n\nCruzeiro B-ORG\n2 O\nFlamengo B-ORG\n1 O\n\nGoias B-ORG\n0 O\nPalmeiras B-ORG\n0 O\n\nGremio B-ORG\n2 O\nVitoria B-ORG\n2 O\n\nJuventude B-ORG\n2 O\nInternacional B-ORG\n1 O\n\nParana B-ORG\n3 O\nGuarani B-ORG\n0 O\n\nPortuguesa B-ORG\n3 O\nAtletico B-ORG\nMineiro I-ORG\n1 O\n\nSao B-ORG\nPaulo I-ORG\n2 O\nSantos B-ORG\n1 O\n\nSport B-ORG\nRecife I-ORG\n3 O\nCoritiba B-ORG\n0 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nSao B-ORG\nPaulo I-ORG\n4 O\n3 O\n1 O\n0 O\n10 O\n5 O\n10 O\n\nJuventude B-ORG\n5 O\n3 O\n1 O\n1 O\n5 O\n4 O\n10 O\n\nPortuguesa B-ORG\n4 O\n3 O\n0 O\n1 O\n8 O\n3 O\n9 O\n\nPalmeiras B-ORG\n5 O\n2 O\n3 O\n0 O\n8 O\n1 O\n9 O\n\nGoias B-ORG\n5 O\n2 O\n2 O\n1 O\n7 O\n4 O\n8 O\n\nGremio B-ORG\n3 O\n2 O\n1 O\n0 O\n11 O\n4 O\n7 O\n\nCruzeiro B-ORG\n3 O\n2 O\n1 O\n0 O\n4 O\n2 O\n7 O\n\nSport B-ORG\nRecife I-ORG\n5 O\n2 O\n1 O\n2 O\n7 O\n6 O\n7 O\n\nParana B-ORG\n4 O\n2 O\n1 O\n2 O\n5 O\n5 O\n7 O\n\nFlamengo B-ORG\n4 O\n2 O\n0 O\n2 O\n4 O\n4 O\n6 O\n\nAtletico B-ORG\nMineiro I-ORG\n5 O\n2 O\n0 O\n3 O\n6 O\n7 O\n6 O\n\nVasco B-ORG\nda I-ORG\nGama I-ORG\n4 O\n2 O\n0 O\n2 O\n6 O\n7 O\n6 O\n\nCoritiba B-ORG\n5 O\n2 O\n0 O\n3 O\n3 O\n9 O\n6 O\n\nBotafogo B-ORG\n3 O\n1 O\n2 O\n0 O\n4 O\n3 O\n5 O\n\nInternacional B-ORG\n4 O\n1 O\n2 O\n1 O\n4 O\n3 O\n5 O\n\nCriciuma B-ORG\n5 O\n1 O\n2 O\n2 O\n7 O\n8 O\n5 O\n\nVitoria B-ORG\n5 O\n1 O\n2 O\n2 O\n5 O\n6 O\n5 O\n\nSantos B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n3 O\n4 O\n\nCorinthians B-ORG\n4 O\n1 O\n1 O\n2 O\n1 O\n3 O\n4 O\n\nBahia B-ORG\n5 O\n1 O\n1 O\n3 O\n5 O\n8 O\n4 O\n\nFluminense B-ORG\n4 O\n1 O\n1 O\n2 O\n3 O\n6 O\n4 O\n\nAtletico B-ORG\nParanaense I-ORG\n3 O\n1 O\n0 O\n2 O\n4 O\n6 O\n3 O\n\nGuarani B-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n5 O\n1 O\n\nBragantino B-ORG\n4 O\n0 O\n0 O\n4 O\n3 O\n12 O\n0 O\n\nNote O\n: O\nTop O\neight O\nteams O\nqualify O\nfor O\nthe O\nquarter-finals O\n. O\n\nIf O\n\nteams O\nare O\nlevel O\non O\npoints O\n, O\npositions O\nare O\ndetermined O\nby O\nthe O\n\nnumber O\nof O\ngames O\nwon O\n. O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nPHILIPPINE B-MISC\nPRO-LEAGUE O\nRESULTS O\n. O\n\nMANILA B-LOC\n1996-08-26 O\n\nResults O\nof O\nsemi-final O\nround O\ngames O\nplayed O\non O\nlate O\nSunday O\nin O\nthe O\nPhilippine B-ORG\nBasketball I-ORG\nAssociation I-ORG\nsecond O\nconference O\n, O\nwhich O\nincludes O\nAmerican B-MISC\nplayers O\n: O\n\nFormula B-ORG\nShell I-ORG\nbeat O\nGinebra B-ORG\nSan I-ORG\nMiguel I-ORG\n89-86 O\n( O\n45-46 O\nhalf-time O\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nRESULTS O\nOF O\nSOUTH B-MISC\nKOREAN I-MISC\nPRO-SOCCER O\nGAMES O\n. O\n\nSEOUL B-LOC\n1996-08-26 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\npro-soccer O\n\ngames O\nplayed O\non O\nSunday O\n. O\n\nPuchon B-ORG\n3 O\nChonan B-ORG\n0 O\n( O\nhalftime O\n1-0 O\n) O\n\nPohang B-ORG\n3 O\nChonbuk B-ORG\n2 O\n( O\nhalftime O\n0-0 O\n) O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nSunday O\n( O\ntabulate O\nunder O\n- O\n\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nW O\nD O\nL O\nG O\n/ O\nF O\nG O\n/ O\nA O\nP O\n\nPuchon B-ORG\n2 O\n1 O\n0 O\n4 O\n0 O\n7 O\n\nChonan B-ORG\n2 O\n0 O\n1 O\n9 O\n9 O\n6 O\n\nPohang B-ORG\n1 O\n1 O\n1 O\n8 O\n8 O\n4 O\n\nUlsan B-ORG\n1 O\n0 O\n1 O\n6 O\n6 O\n3 O\n\nAnyang B-ORG\n0 O\n3 O\n0 O\n5 O\n5 O\n3 O\n\nSuwon B-ORG\n0 O\n3 O\n0 O\n3 O\n3 O\n3 O\n\nPusan B-ORG\n0 O\n2 O\n0 O\n3 O\n3 O\n2 O\n\nChonnam B-ORG\n0 O\n2 O\n1 O\n4 O\n5 O\n2 O\n\nChonbuk B-ORG\n0 O\n0 O\n2 O\n2 O\n5 O\n0 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nRESULTS O\nOF O\nS. B-MISC\nKOREAN I-MISC\nPRO-BASEBALL O\nGAMES O\n. O\n\nSEOUL B-LOC\n1996-08-26 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\n\npro-baseball O\ngames O\nplayed O\non O\nSunday O\n. O\n\nOB B-ORG\n2 O\nLotte B-ORG\n1 O\n\nHanwha B-ORG\n3 O\nHaitai B-ORG\n2 O\n\nHyundai B-ORG\n8 O\nSamsung B-ORG\n1 O\n\nSsangbangwool B-ORG\n3 O\nLG B-ORG\n1 O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nSunday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\ndrawn O\n, O\nlost O\n, O\nwinning O\npercentage O\n, O\ngames O\nbehind O\nfirst O\nplace O\n) O\n\nW O\nD O\nL O\nPCT O\nGB O\n\nHaitai B-ORG\n63 O\n2 O\n41 O\n.604 O\n- O\n\nSsangbangwool B-ORG\n58 O\n2 O\n47 O\n.551 O\n5 O\n1/2 O\n\nHyundai B-ORG\n56 O\n5 O\n47 O\n.542 O\n6 O\n1/2 O\n\nHanwha B-ORG\n56 O\n1 O\n48 O\n.538 O\n7 O\n\nSamsung B-ORG\n47 O\n5 O\n55 O\n.463 O\n15 O\n\nLotte B-ORG\n44 O\n6 O\n53 O\n.456 O\n15 O\n1/2 O\n\nLG B-ORG\n44 O\n5 O\n58 O\n.435 O\n18 O\n\nOB B-ORG\n41 O\n6 O\n60 O\n.411 O\n20 O\n1/2 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nMOROCCAN B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n. O\n\nRABAT B-LOC\n1996-08-26 O\n\nResults O\nof O\nMoroccan B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatches O\nplayed O\non O\nSunday O\n: O\n\nWidad B-ORG\nFes I-ORG\n3 O\nOujda B-ORG\n1 O\n\nRaja B-ORG\nCasablanca I-ORG\n4 O\nTetouan B-ORG\n0 O\n\nJeunesse B-ORG\nMassira I-ORG\n0 O\nWidad B-ORG\nCasablanca I-ORG\n2 O\n\nSporting B-ORG\nSale I-ORG\n0 O\nMeknes B-ORG\n1 O\n\nSettat B-ORG\n1 O\nMarrakesh B-ORG\n0 O\n\nKhouribga B-ORG\n3 O\nMohammedia B-ORG\n0 O\n\nSidi B-ORG\nKacem I-ORG\n0 O\nRoyal B-ORG\nArmed I-ORG\nForces I-ORG\n0 O\n\nEl B-ORG\nJadida I-ORG\n1 O\nHassania B-ORG\nAgadir I-ORG\n0 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nQUENCH O\nYOUR O\nTHIRST O\n- O\nIF O\nYOU O\nCAN O\nAFFORD O\nIT O\nAT O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nBill B-PER\nBerkrot I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-26 O\n\nA O\nmessage O\non O\ntelevision O\nmonitors O\nall O\naround O\nthe O\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\nreads O\n: O\n\" O\nDue O\nto O\nhot O\nweather O\nplease O\nseek O\nshade O\nand O\ndrink O\nplenty O\nof O\nfluids O\n\" O\n-- O\nsound O\nadvice O\nuntil O\nyou O\ncheck O\nout O\nthe O\nprice O\nof O\nfluids O\n. O\n\nPerhaps O\nthe O\nadvisory O\nwas O\ncut O\noff O\nbefore O\nconcluding O\n: O\n\" O\n...and O\nbring O\nplenty O\nof O\nmoney O\n. O\n\" O\n\nA O\nsmall O\nbottle O\nof O\na O\ngarishly-coloured O\nsports O\ndrink O\nat O\nthe O\nsun-drenched O\nU.S. B-MISC\nOpen I-MISC\nis O\ngoing O\nfor O\n$ O\n3.75 O\n, O\nwhile O\na O\nlitre O\nof O\nbasic O\n, O\nlife-sustaining O\nwater O\nwill O\nset O\nyou O\nback O\n$ O\n4.00 O\n-- O\nfor O\nwater O\n? O\n\n\" O\nAt O\nthe O\nOlympics B-MISC\nwater O\nwas O\nonly O\na O\ndollar O\n, O\nand O\nthat O\nwas O\nthe O\nOlympics B-MISC\n, O\n\" O\nsaid O\none O\nincredulous O\nfan O\n, O\nnoting O\nthat O\nthe O\nAtlanta B-MISC\nGames I-MISC\nhad O\nbeen O\nnotorious O\nfor O\nprice O\ngouging O\n. O\n\nU.S. B-MISC\nOpen I-MISC\nofficials O\nmanaged O\nto O\ninsult O\nmost O\nof O\nthe O\nmale O\ntennis O\nplayers O\nlast O\nweek O\nwith O\ntheir O\ncontroversial O\nhandling O\nof O\nthe O\nseeding O\nand O\ndraw O\n. O\n\nWhen O\nthe O\ntournament O\nbegan O\non O\nMonday O\nit O\nwas O\nthe O\nfans O\n' O\nturn O\nto O\nbe O\noffended O\n. O\n\n\" O\nThat O\nbaked O\nlasagna O\nbetter O\nbe O\ngood O\nfor O\n$ O\n8.50 O\n, O\n\" O\nsaid O\nNew B-MISC\nYorker I-MISC\nRebecca B-PER\nWeinstein I-PER\n, O\na O\nU.S. B-MISC\nOpen I-MISC\nregular O\nwho O\nwas O\neating O\na O\nsandwich O\nshe O\nhad O\nbrought O\nfrom O\nhome O\n. O\n\nA O\ntrio O\nof O\nhungry O\nfans O\nat O\nthe O\nfood O\ncourt O\nwho O\nhad O\nalready O\nforked O\nover O\nthe O\nlasagna O\nmoney O\npronounced O\nit O\ngood O\n, O\nbut O\nCarol B-PER\nPerry I-PER\nchimed O\nin O\n, O\n\" O\nThe O\nwater O\nis O\nridiculous O\n, O\nthey O\nwant O\nfour O\ndollars O\nfor O\nthe O\nwater O\n, O\nyou O\nmight O\nas O\nwell O\nget O\na O\nglass O\nof O\nwine O\n. O\n\" O\n\nIndeed O\n, O\na O\nnice O\nglass O\nof O\nchardonnay O\nor O\nwhite O\nzinfandel O\nwas O\ngoing O\nfor O\n$ O\n4.75 O\n, O\nwhile O\nan O\nimported O\nbeer O\nwas O\njust O\na O\nbit O\nmore O\nthan O\nthe O\nwater O\nat O\n$ O\n4.50 O\n. O\n\nWhat O\n's O\nthe O\nmessage O\nhere O\n? O\n\" O\n\nMaybe O\nthey O\nwant O\nus O\nto O\nbe O\nalcoholics O\n, O\n\" O\nPerry B-PER\njoked O\nbefore O\nlifting O\nher O\nglass O\nof O\nwine O\n. O\n\nFans O\nwill O\nbe O\nshelling O\nout O\n$ O\n12.50 O\nfor O\na O\nhamburger O\nand O\na O\nlarge O\nfrench O\nfries O\n. O\n\nAnd O\nthat O\nlittle O\nsnack O\nis O\nguaranteed O\nto O\nmake O\nyou O\nthirsty O\n. O\n\nMake O\nthat O\n$ O\n16.50 O\n. O\n\nEven O\na O\nsandwich O\nas O\npedestrian O\nas O\na O\nham O\nand O\nswiss O\ncheese O\nis O\ngoing O\nfor O\na O\nwhopping O\n$ O\n8.00 O\n. O\n\nOf O\ncourse O\n, O\nit O\nis O\nserved O\non O\na O\ntuscan O\nroll O\n. O\n\nIt O\nmust O\nbe O\nthe O\ncost O\nof O\nflying O\nthose O\nrolls O\nover O\nfrom O\nTuscany B-LOC\nevery O\nday O\nthat O\ndrives O\nup O\nthe O\nprice O\nof O\nthe O\nsandwich O\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nHUBER B-PER\nAND O\nMALEEVA B-PER\nFALL O\n, O\nUP-AND-COMERS O\nADVANCE O\nAT O\nOPEN B-MISC\n. O\n\nLarry B-PER\nFine I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-26 O\n\nMartina B-PER\nHingis I-PER\nled O\na O\nyouthful O\ncharge O\nand O\nAustralian B-MISC\nOpen I-MISC\nfinalist O\nAnke B-PER\nHuber I-PER\nand O\nMagdalena B-PER\nMaleeva I-PER\nwere O\nfallen O\nseeds O\non O\nMonday O\nin O\na O\nhot O\n, O\nsunny O\nopening O\nto O\nthe O\nU.S. B-MISC\nOpen I-MISC\ntennis O\nchampionships O\n. O\n\nThe O\n15-year-old O\nHingis B-PER\n, O\nseeded O\n16th O\n, O\nwas O\nhonoured O\nto O\nplay O\nthe O\nfirst O\nmatch O\nof O\nthe O\nseason O\n's O\nlast O\nGrand B-MISC\nSlam I-MISC\non O\nStadium B-LOC\nCourt I-LOC\nbut O\nhappy O\nto O\nhurry O\noff O\nwith O\na O\nstraight-sets O\nvictory O\nover O\nthe O\n112th-ranked O\nAngeles B-PER\nMontolio I-PER\nof O\nSpain B-LOC\n. O\n\n\" O\nIt O\nwas O\nvery O\nhot O\nand O\nI O\ndid O\nn't O\nwant O\nto O\nstay O\nlong O\non O\nthe O\ncourt O\n, O\n\" O\nsaid O\na O\ncheery O\nHingis B-PER\n, O\nwho O\nhad O\nno O\nworries O\nin O\nracing O\nto O\na O\n6-1 O\n6-0 O\nvictory O\nagainst O\nthe O\novermatched O\nSpaniard B-MISC\n. O\n\nHoping O\nfor O\na O\nlonger O\nengagement O\non O\nthe O\ncement O\nat O\nFlushing B-LOC\nMeadows I-LOC\nwere O\nthe O\nsixth-seeded O\nHuber B-PER\nof O\nGermany B-LOC\nand O\n12th O\nseed O\nMaleeva B-PER\nof O\nBulgaria B-LOC\n. O\n\nHuber B-PER\n, O\nwho O\nlost O\nto O\nMonica B-PER\nSeles I-PER\nin O\nthe O\nAustralian B-MISC\nOpen I-MISC\nfinal O\n, O\nfell O\nvictim O\nto O\nan O\nunfortunate O\ndraw O\nin O\nbowing O\nto O\ndangerous O\nfloater O\nAmanda B-PER\nCoetzer I-PER\nof O\nSouth B-LOC\nAfrica I-LOC\n. O\n\nCoetzer B-PER\n, O\nranked O\n17th O\n, O\navenged O\nher O\ndefeat O\nto O\nHuber B-PER\nin O\nthe O\nAustralian B-MISC\nOpen I-MISC\nsemifinals O\nby O\nwinning O\n6-1 O\n2-6 O\n6-2 O\n. O\n\n\" O\nI O\nlooked O\nat O\nit O\nas O\nnot O\na O\nfirst O\nround O\nmatch O\n, O\njust O\na O\ngreat O\nchallenge O\nfor O\nme O\n, O\n\" O\nsaid O\nCoetzer B-PER\n, O\n24 O\n. O\n\" O\n\nI O\nwas O\nreally O\nconcentrating O\non O\nkeeping O\nmy O\nown O\nmomentum O\nand O\nmy O\nown O\nrhythm O\n. O\n\n\" O\nShe O\nis O\ntough O\nto O\nplay O\nin O\nthat O\nway O\nbecause O\nshe O\nplays O\nvery O\nup O\nand O\ndown O\n. O\n\nShe O\nplayed O\none O\ngreat O\ngame O\nand O\nthan O\na O\nfew O\nerrors O\n. O\n\nThe O\nchallenge O\nwas O\njust O\nfor O\nme O\nto O\nkeep O\nplaying O\nmy O\nown O\ngame O\n. O\n\" O\n\nHuber B-PER\n, O\nwho O\nreached O\nthe O\nfinal O\na O\nweek O\nago O\nat O\nManhattan B-LOC\nBeach I-LOC\n, O\ncould O\nonly O\nmourn O\nher O\nluck O\nof O\nthe O\ndraw O\n. O\n\n\" O\nI O\nwas O\nn't O\nhappy O\nwhen O\nI O\nsaw O\nthe O\ndraw O\n. O\n\nShe O\nwas O\nthe O\nfirst O\nnon- O\nseeded O\nplayer O\n, O\n\" O\nsaid O\nthe O\n21-year-old O\nGerman B-MISC\n. O\n\" O\n\nIt O\n's O\nalways O\ntough O\nto O\nplay O\nsomebody O\nlike O\nthat O\nin O\nthe O\nfirst O\nround O\nin O\na O\nGrand B-MISC\nSlam I-MISC\n. O\n\n\" O\nI O\nthink O\nI O\ndid O\nn't O\nplay O\nthat O\nbad O\ntoday O\n. O\n\nIt O\nwas O\nmaybe O\nmy O\nbest O\nfirst O\nround O\nmatch O\nin O\na O\nGrand B-MISC\nSlam I-MISC\nI O\never O\nplayed O\n. O\n\" O\n\nMonday O\nbrought O\nthe O\nbest O\nout O\nin O\nU.S. B-MISC\nOpen I-MISC\nrookie O\nAleksandra B-PER\nOlsza I-PER\nof O\nPoland B-LOC\n, O\nranked O\n110th O\n. O\n\nThe O\n18-year-old O\nOlsza B-PER\n, O\nlast O\nyear O\n's O\nWimbledon B-MISC\njunior O\nchampion O\n, O\ncelebrated O\nher O\ndebut O\nin O\nthe O\nmain O\ndraw O\nof O\nthe O\nOpen B-MISC\nby O\nremoving O\nMaleeva B-PER\n6-4 O\n6-2 O\n. O\n\nThe O\ncurtain-raising O\nvictories O\nby O\nHingis B-PER\nand O\nOlsza B-PER\nprovided O\na O\nringing O\nendorsement O\nfor O\nthe O\nnewest O\nwave O\nof O\nwomen O\n's O\nplayers O\ncoming O\nup O\nfrom O\nthe O\njunior O\nranks O\n. O\n\nThe O\nSwiss B-MISC\nteenager O\n, O\na O\ntwice O\nFrench B-MISC\nOpen I-MISC\njunior O\nchampion O\nand O\na O\nWimbledon B-MISC\njuniors O\nwinner O\n, O\nhad O\nalready O\nproven O\nher O\nmain O\nstage O\nmettle O\nby O\nreaching O\nthe O\nquarters O\nat O\nthis O\nyear O\n's O\nAustralian B-MISC\nOpen I-MISC\n. O\n\n\" O\nI O\nhope O\nI O\ncan O\nget O\ninto O\nthe O\nlast O\n16 O\n, O\n\" O\nsaid O\nHingis B-PER\n, O\nseeded O\nto O\nface O\nthird O\nseed O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\nin O\nthe O\nfourth O\nround O\n. O\n\nHingis B-PER\nhas O\nbeen O\nworking O\nhard O\non O\nconditioning O\nand O\nhas O\nlost O\neight O\npounds O\n( O\n3.5 O\nkilos O\n) O\nin O\nadvance O\nof O\nthe O\nchampionships O\n. O\n\n\" O\nThere O\nwill O\nbe O\ntough O\nmatches O\nbut O\nI O\nhope O\nI O\ncan O\nget O\nthere O\n, O\n\" O\nshe O\nsaid O\n. O\n\" O\n\nThen O\nwe O\n'll O\nsee O\nif O\nArantxa B-PER\nwill O\nbe O\nthere O\n, O\ntoo O\n. O\n\" O\n\nThe O\nfast-moving O\nOlsza B-PER\n, O\n18 O\n, O\nwas O\ncool O\nin O\nher O\nopening O\nmatch O\n. O\n\n\" O\nI O\nwas O\nn't O\nscared O\nwhen O\nI O\nheard O\nthat O\nI O\nwas O\nplaying O\nMaleeva B-PER\n, O\n\" O\nsaid O\nOlsza B-PER\n. O\n\" O\n\nI O\nknow O\nthat O\nif O\nI O\nwant O\nto O\nplay O\nprofessional O\ntennis O\nI O\nhave O\nto O\ndo O\nmy O\nbest O\nto O\ntry O\nto O\nbeat O\nher O\nand O\nI O\nca O\nn't O\nbe O\nscared O\n. O\n\" O\n\nOlsza B-PER\nis O\nundaunted O\nby O\nthe O\nlevel O\nof O\ncompetition O\nin O\nthe O\npros O\n. O\n\n\" O\nIn O\nterms O\nof O\ntennis O\n, O\nI O\nthink O\nthe O\njunior O\nplayers O\nare O\nreally O\ngood O\nnow O\n. O\n\nIn O\na O\nfew O\nyears O\n, O\nit O\ncould O\nchange O\na O\nlot O\namong O\nthe O\ntop O\nplayers O\n. O\n\" O\n\nTwo O\nbig-serving O\nwomen O\n's O\nplayers O\nmade O\nquick O\nwork O\nof O\nJapanese B-MISC\nopponents O\n. O\n\nBrenda B-PER\nSchultz-McCarthy I-PER\nof O\nthe O\nNetherlands B-LOC\n, O\nthe O\n13th O\nseed O\n, O\nwas O\na O\n6-1 O\n6-4 O\nwinner O\nover O\nJapan B-LOC\n's O\nNana B-PER\nMiyaga I-PER\n, O\nwhile O\nCzech B-MISC\nveteran O\nHelena B-PER\nSukova I-PER\nprevailed O\nover O\nYone B-PER\nKamio I-PER\n6-2 O\n6-3 O\n. O\n\nAustrian B-MISC\nBarbara B-PER\nPaulus I-PER\n, O\nseeded O\n14th O\n, O\nalso O\nreached O\nthe O\nsecond O\nround O\nwith O\na O\n6-2 O\n6-1 O\nvictory O\nover O\nYi B-PER\nJing-Qian I-PER\nof O\nChina B-LOC\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nSTICH B-PER\nGLAD O\nHE O\nSTAYED O\nAFTER O\nOPEN B-MISC\nVICTORY O\n. O\n\nRichard B-PER\nFinn I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-26 O\n\nMichael B-PER\nStich I-PER\nnearly O\npulled O\nout O\nof O\nthe O\nU.S. B-MISC\nOpen I-MISC\nin O\nprotest O\nover O\nthe O\nmen O\n's O\nseeding O\nfiasco O\nbut O\nthe O\nformer O\nWimbledon B-MISC\nchampion O\nwas O\nglad O\nhe O\nstayed O\nafter O\nsweating O\nout O\na O\nfour-set O\nwin O\non O\nMonday O\nover O\nqualifier O\nTommy B-PER\nHaas I-PER\n. O\n\n\" O\nI O\nstill O\nfeel O\nit O\n's O\nembarrassing O\nwhat O\nhappened O\nand O\nI O\nwas O\nabout O\nto O\npull O\nout O\nyesterday O\nand O\nsay O\n, O\n' O\nThat O\n's O\nit O\n, O\n' O\n\" O\nsaid O\nStich B-PER\n, O\none O\nof O\na O\nhost O\nof O\nmen O\nwho O\ncried O\nfoul O\nover O\nseeding O\nprocedures O\nthat O\nforced O\nan O\nunprecedented O\nremaking O\nof O\nthe O\nmen O\n's O\ndraw O\nlast O\nweek O\n. O\n\n\" O\nBut O\nthere O\nare O\nso O\nmany O\nreasons O\nto O\nplay O\n, O\nespecially O\nspectators O\nand O\nthe O\nkids O\nwho O\ncome O\nout O\nhere O\nand O\nwant O\nto O\nenjoy O\nwatching O\ntennis O\n, O\nthat O\nI O\ndecided O\nto O\nstay O\n. O\n\" O\n\nIn O\na O\nbreak O\nfrom O\ntradition O\n, O\nthe O\nOpen B-MISC\ndid O\nnot O\nseed O\nin O\nstrict O\naccordance O\nwith O\nATP B-ORG\nrankings O\n, O\ninstead O\ntaking O\ninto O\naccount O\nother O\nfactors O\nthat O\nraised O\nobjections O\nof O\nfavourtism O\ntoward O\nU.S. B-LOC\nplayers O\n. O\n\nOne O\nprominent O\nplayer O\nthat O\ndid O\nnot O\nstay O\nfor O\nthe O\nOpen B-MISC\nwas O\nFrench B-MISC\nOpen I-MISC\nchampion O\nYvegeny B-PER\nKafelnikov I-PER\n, O\nwho O\nafter O\nbeing O\ndropped O\nthree O\nspots O\nfrom O\nhis O\nATP B-ORG\nranking O\nto O\na O\nseventh O\nseeding O\n, O\nwithdrew O\nand O\nreturned O\nhome O\nto O\nRussia B-LOC\n. O\n\nKafelnikov B-PER\nhad O\npulled O\nout O\nof O\nlast O\nweek O\n's O\ntournament O\nwith O\na O\nrib O\ninjury O\n. O\n\nAt O\na O\nnews O\nconference O\nattended O\nby O\napproximately O\n50 O\nplayers O\non O\nSunday O\n, O\nU.S. B-LOC\nDavis B-MISC\nCup I-MISC\nplayer O\nTodd B-PER\nMartin I-PER\nexpressed O\nthe O\nplayers O\n' O\noutrage O\nat O\nthe O\nseedings O\n. O\n\n\" O\nThe O\nway O\nthe O\nU.S. B-MISC\nOpen I-MISC\nhas O\nseeded O\nhere O\n, O\ntampering O\nwith O\nthe O\nranking O\nsystem O\n, O\nhas O\ntarnished O\nthe O\nimage O\nand O\nreputation O\nof O\nthis O\nU.S. B-MISC\nOpen I-MISC\nin O\nthe O\nplayers O\n' O\nmind O\n, O\nand O\nwe O\nthink O\nthat O\nis O\ndamaging O\nto O\nour O\nsport O\n, O\n\" O\nMartin B-PER\nsaid O\n. O\n\nStich B-PER\nsaid O\nhe O\nfelt O\nthe O\nplayers O\nought O\nto O\nhave O\norganised O\nan O\nactive O\nprotest O\n. O\n\n\" O\nI O\nfeel O\nthat O\nwe O\nmade O\nit O\na O\nlittle O\neasy O\nfor O\nthe O\nUSTA B-ORG\n. O\n\nThey O\ndid O\nn't O\nreally O\nget O\nhurt O\nas O\nmuch O\nas O\nI O\nthink O\nthey O\nshould O\nhave O\n, O\n\" O\nsaid O\nStich B-PER\n. O\n\" O\n\nI O\nfeel O\nthat O\nwe O\nshould O\nhave O\nmaybe O\njust O\ncancelled O\nout O\nthe O\nMonday O\n, O\nnot O\nshow O\nup O\ntoday O\nand O\nstart O\nthe O\ntournament O\ntomorrow O\n. O\n\" O\n\nBut O\nonce O\nthe O\n27-year-old O\nStich B-PER\ngot O\non O\nthe O\ncourt O\n, O\nhe O\nfocused O\nhis O\nenergies O\non O\ntrying O\nto O\nwin O\nthe O\nyear O\n's O\nlast O\nGrand B-MISC\nSlam I-MISC\n. O\n\nHe O\ntook O\na O\npositive O\nfirst O\nstep O\nwith O\nhis O\n6-3 O\n1-6 O\n6-1 O\n7-5 O\nwin O\nover O\ncompatriot O\nHaas B-PER\non O\na O\nsun-baked O\nGrandstand B-MISC\ncourt O\n. O\n\nOthers O\nadvancing O\nearly O\non O\nMonday O\nincluded O\n11th-seeded O\nAmerican B-MISC\nMalivai B-PER\nWashington I-PER\n, O\nthe O\nWimbledon B-MISC\nrunner-up O\n, O\nSweden B-LOC\n's O\nMagnus B-PER\nGustafsson I-PER\n, O\nand O\ntwo-time O\nformer O\nFrench B-MISC\nOpen I-MISC\nchampion O\nSergi B-PER\nBruguera I-PER\nof O\nSpain B-LOC\n, O\nwho O\nwill O\nbe O\nStich B-PER\n's O\nnext O\nopponent O\n. O\n\nThe O\nsuspicion O\n, O\nhowever O\n, O\nlingers O\nin O\nStich B-PER\n's O\nmind O\nthat O\nU.S. B-MISC\nOpen I-MISC\nofficials O\ndid O\ntamper O\nwith O\nthe O\nseeding O\nprocess O\nin O\norder O\nto O\nbenefit O\nhomegrown O\nplayers O\n. O\n\n\" O\nI O\nget O\nthe O\nfeeling O\nthat O\neverything O\nis O\ndone O\nhere O\nfor O\nthe O\nAmerican B-MISC\nplayers O\nand O\nthey O\nforget O\nabout O\nall O\nthe O\nother O\nplayers O\n, O\n\" O\nsaid O\nStich B-PER\n, O\nwho O\nlost O\nthe O\n1994 O\nOpen B-MISC\nfinal O\nto O\nAndre B-PER\nAgassi I-PER\n. O\n\nIt O\nwas O\nAgassi B-PER\nwho O\nwas O\nat O\nthe O\ncentre O\nof O\nthe O\ncontroversy O\nthat O\nengulfed O\nthe O\ntournament O\nsince O\nthe O\noriginal O\ndraw O\nwas O\ncompleted O\non O\nWednesday O\n. O\n\nThe O\nflamboyant O\nAmerican B-MISC\nstar O\nwas O\nbumped O\nup O\ntwo O\nspots O\nfrom O\nhis O\nATP B-ORG\nranking O\nof O\neight O\nto O\na O\nseeding O\nof O\nsix O\n. O\n\n\" O\nHe O\n( O\nAgassi B-PER\n) O\nshould O\nbe O\nseeded O\nthe O\nway O\nhe O\nis O\nplaying O\ntennis O\nright O\nnow O\n, O\n\" O\nsaid O\nStich B-PER\nabout O\nthe O\nunfairness O\nof O\nmoving O\nup O\nAgassi B-PER\n, O\nwho O\nmade O\nearly O\nexits O\nfrom O\nthe O\nFrench B-MISC\nOpen I-MISC\nand O\nWimbledon B-MISC\n. O\n\nStich B-PER\n, O\nnot O\nseeded O\nhere O\nfor O\nthe O\nfirst O\ntime O\nsince O\n1990 O\n, O\nmight O\nhave O\nbenefitted O\nfrom O\nsome O\nfiddling O\nwith O\nthe O\nseedings O\nhimself O\nafter O\nKafelnikov B-PER\nwithdrew O\n. O\n\nRanked O\n18th O\nin O\nthe O\nworld O\n, O\nStich B-PER\nmight O\nhave O\nbeen O\nslipped O\ninto O\nthat O\nspot O\nahead O\nof O\nSpain B-LOC\n's O\nFelix B-PER\nMantilla I-PER\n, O\nwho O\nis O\n16th O\nbut O\nhad O\nnever O\nbeen O\nplayed O\nin O\nthe O\nOpen B-MISC\nand O\nhad O\nbeen O\nleft O\nout O\nof O\nthe O\nseedings O\noriginally O\n. O\n\nBut O\nStich B-PER\ndid O\nn't O\nwant O\nto O\nplay O\nthat O\ngame O\n. O\n\n\" O\nI O\nthink O\nhe O\ndeserves O\nto O\nbe O\nseeded O\nas O\neverybody O\nelse O\nwho O\nis O\nin O\nthe O\ntop O\n16 O\ndeserves O\nto O\nbe O\nseeded O\n, O\n\" O\nStich B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nMONDAY O\n'S O\nRESULTS O\nFROM O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-26 O\n\nResults O\nof O\nfirst O\nround O\nmatches O\non O\nMonday O\nin O\nthe O\nU.S. B-MISC\nOpen I-MISC\ntennis O\nchampionships O\nat O\nthe O\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\n( O\nprefix O\ndenotes O\nseeding O\n) O\n: O\n\nWomen O\n's O\nsingles O\n\n16 O\n- O\nMartina B-PER\nHingis I-PER\n( O\nSwitzerland B-LOC\n) O\nbeat O\nAngeles B-PER\nMontolio I-PER\n( O\nSpain B-LOC\n) O\n6-1 O\n6-0 O\n\nAnne-Gaelle B-PER\nSidot I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nJanette B-PER\nHusarova I-PER\n( O\nSlovakia B-LOC\n) O\n6-4 O\n6-4 O\n\n13 O\n- O\nBrenda B-PER\nSchultz-McCarthy I-PER\n( O\nNetherlands B-LOC\n) O\nbeat O\nNana B-PER\nMiyagi I-PER\n( O\nJapan B-LOC\n) O\n6-1 O\n6-4 O\n\nAleksandra B-PER\nOlsza I-PER\n( O\nPoland B-LOC\n) O\nbeat O\n12 O\n- O\nMagdalena B-PER\nMaleeva I-PER\n( O\nBulgaria B-LOC\n) O\n6-4 O\n6-2 O\n\nMen O\n's O\nsingles O\n\nMichael B-PER\nStich I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nTommy B-PER\nHaas I-PER\n( O\nGermany B-LOC\n) O\n6-3 O\n1-6 O\n6-1 O\n7-5 O\n\nSergi B-PER\nBruguera I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nKris B-PER\nGoossens I-PER\n( O\nBelgium B-LOC\n) O\n6-2 O\n6-0 O\n7-6 O\n( O\n7-1 O\n) O\n\nFrederic B-PER\nVitoux I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nRamon B-PER\nDelgado I-PER\n( O\nParaguay B-LOC\n) O\n6-4 O\n6-4 O\n7-6 O\n( O\n7-3 O\n) O\n\nWomen O\n's O\nsingles O\n\nHenrietta B-PER\nNagyova I-PER\n( O\nSlovakia B-LOC\n) O\nbeat O\nGala B-PER\nLeon I-PER\nGarcia I-PER\n( O\nSpain B-LOC\n) O\n6-1 O\n4-6 O\n6-3 O\n\nAsa B-PER\nCarlsson I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nGloria B-PER\nPizzichini I-PER\n( O\nItaly B-LOC\n) O\n3-6 O\n6-1 O\n7-5 O\n\nBarbara B-PER\nSchett I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nSabine B-PER\nAppelmans I-PER\n( O\nBelgium B-LOC\n) O\n1-6 O\n6-4 O\n6-4 O\n\nCristina B-PER\nTorrens-Valero I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nSabine B-PER\nHack I-PER\n( O\nGermany B-LOC\n) O\n2-6 O\n6-4 O\n6-2 O\n\nWomen O\n's O\nsingles O\n\nHelena B-PER\nSukova I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nYone B-PER\nKamio I-PER\n( O\nJapan B-LOC\n) O\n6-2 O\n6-3 O\n\nIrina B-PER\nSpirlea I-PER\n( O\nRomania B-LOC\n) O\nbeat O\nPetra B-PER\nBegerow I-PER\n( O\nGermany B-LOC\n) O\n6-3 O\n6-2 O\n\nMaria B-PER\nJose I-PER\nGaidano I-PER\n( O\nArgentina B-LOC\n) O\nbeat O\nMelanie B-PER\nSchnell I-PER\n( O\nAustria B-LOC\n) O\n6-4 O\n6-0 O\n\nMen O\n's O\nsingles O\n\nCarlos B-PER\nMoya I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nScott B-PER\nHumphries I-PER\n( O\nU.S. B-LOC\n) O\n6-1 O\n6-7 O\n( O\n3-7 O\n) O\n6-7 O\n( O\n1-7 O\n) O\n6-0 O\n6-4 O\n\nKenneth B-PER\nCarlsen I-PER\n( O\nDenmark B-LOC\n) O\nbeat O\nPatrick B-PER\nRafter I-PER\n( O\nAustralia B-LOC\n) O\n7-6 O\n( O\n9-7 O\n) O\n6-3 O\n7-6 O\n( O\n8-6 O\n) O\n\nMagnus B-PER\nGustafsson I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nCarlos B-PER\nCosta I-PER\n( O\nSpain B-LOC\n) O\n7-5 O\n4-6 O\n7-6 O\n( O\n7-4 O\n) O\n6-3 O\n\nJeff B-PER\nTarango I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAlex B-PER\nRadulescu I-PER\n( O\nRomania B-LOC\n) O\n6-7 O\n( O\n5-7 O\n) O\n6-4 O\n6-1 O\nretired O\n, O\nheat O\nexhaustion O\n\nMen O\n's O\nsingles O\n\n11 O\n- O\nMaliVai B-PER\nWashington I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nKarim B-PER\nAlami I-PER\n( O\nMorocco B-LOC\n) O\n6-4 O\n2-6 O\n7-6 O\n( O\n7-5 O\n) O\n6-1 O\n\nDirk B-PER\nDier I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nChuck B-PER\nAdams I-PER\n( O\nU.S. B-LOC\n) O\n6-4 O\n2-6 O\n6-4 O\n6-4 O\n\nJason B-PER\nStoltenberg I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nStefano B-PER\nPescosolido I-PER\n( O\nItaly B-LOC\n) O\n7-5 O\n6-4 O\n6-1 O\n\nArnaud B-PER\nBoetsch I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nNicolas B-PER\nPereira I-PER\n( O\nVenezuela B-LOC\n) O\n7-6 O\n( O\n7-4 O\n) O\n6-4 O\n7-5 O\n\nDavid B-PER\nPrinosil I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nPeter B-PER\nTramacchi I-PER\n( O\nAustralia B-LOC\n) O\n6-3 O\n6-2 O\n3-6 O\n6-7 O\n( O\n5-7 O\n) O\n6-1 O\n\nWomen O\n's O\nsingles O\n\nAmanda B-PER\nCoetzer I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\n6 O\n- O\nAnke B-PER\nHuber I-PER\n( O\nGermany B-LOC\n) O\n6-1 O\n2-6 O\n6-2 O\n\nAnna B-PER\nKournikova I-PER\n( O\nRussia B-LOC\n) O\nbeat O\nLudmila B-PER\nRichterova I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n7-6 O\n( O\n7-4 O\n) O\n6-3 O\n\nDebbie B-PER\nGraham I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nStephanie B-PER\nDeville I-PER\n( O\nBelarus B-LOC\n) O\n6-4 O\n6-2 O\n\nBarbara B-PER\nRittner I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nKatarina B-PER\nStudenikova I-PER\n( O\nSlovakia B-LOC\n) O\n7-5 O\n7-5 O\n\nKristina B-PER\nBrandi I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAndrea B-PER\nGlass I-PER\n( O\nGermany B-LOC\n) O\n6-2 O\n6-3 O\n\nInes B-PER\nGorrochategui I-PER\n( O\nArgentina B-LOC\n) O\nbeat O\nMagdalena B-PER\nGrzybowska I-PER\n( O\nPoland B-LOC\n) O\n4-6 O\n6-4 O\n6-1 O\n\nMen O\n's O\nsingles O\n\nAlberto B-PER\nBerasategui I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nCecil B-PER\nMamiit I-PER\n( O\nU.S. B-LOC\n) O\n6-1 O\n6-4 O\n6-0 O\n\nGuillaume B-PER\nRaoux I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nFilip B-PER\nDewulf I-PER\n( O\nBelgium B-LOC\n) O\n7-6 O\n( O\n7-5 O\n) O\n3-6 O\n1-6 O\n6-4 O\n7-5 O\n\nAlex B-PER\nO'Brien I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nNicolas B-PER\nLapentti I-PER\n( O\nEcuador B-LOC\n) O\n6-4 O\n1-6 O\n6-4 O\n6-3 O\n\n2 O\n- O\nMichael B-PER\nChang I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nJaime B-PER\nOncins I-PER\n( O\nBrazil B-LOC\n) O\n3-6 O\n6-1 O\n6-0 O\n7 O\n- O\n6 O\n( O\n8-6 O\n) O\n\nWomen O\n's O\nsingles O\n\n14 O\n- O\nBarbara B-PER\nPaulus I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nYi B-PER\nJing-Qian I-PER\n( O\nChina B-LOC\n) O\n6-2 O\n6-1 O\n\nWang B-PER\nShi-Ting I-PER\n( O\nTaiwan B-LOC\n) O\nbeat O\nCorina B-PER\nMorariu I-PER\n( O\nU.S. B-LOC\n) O\n6-4 O\n6-7 O\n( O\n5-7 O\n) O\n6-2 O\n\nLinda B-PER\nWild I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nSung-Hee B-PER\nPark I-PER\n( O\nSouth B-LOC\nKorea I-LOC\n) O\n6-2 O\n6-3 O\n\nSarah B-PER\nPitkowski I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nMeghann B-PER\nShaughnessy I-PER\n( O\nU.S. B-LOC\n) O\n6-3 O\n6- O\n3 O\n\nDally B-PER\nRandriantefy I-PER\n( O\nMadagascar B-LOC\n) O\nbeat O\nElena B-PER\nMakarova I-PER\n( O\nRussia B-LOC\n) O\n6- O\n3 O\n1-6 O\n7-5 O\n\nLaurence B-PER\nCourtois I-PER\n( O\nBelgium B-LOC\n) O\nbeat O\nFlora B-LOC\nPerfetti B-PER\n( O\nItaly B-LOC\n) O\n6-4 O\n3-6 O\n6-2 O\n\nMen O\n's O\nsingles O\n\nLeander B-PER\nPaes I-PER\n( O\nIndia B-LOC\n) O\nbeat O\nMarcos B-PER\nOndruska I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n7-6 O\n( O\n7-3 O\n) O\n6-2 O\n7-5 O\n\nJan B-PER\nSiemerink I-PER\n( O\nNetherlands B-LOC\n) O\nbeat O\nCarl-Uwe B-PER\nSteeb I-PER\n( O\nGermany B-LOC\n) O\n4-6 O\n6 O\n- O\n1 O\n7-6 O\n( O\n7-4 O\n) O\n6-4 O\n\nNeville B-PER\nGodwin I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\nTomas B-PER\nCarbonell I-PER\n( O\nSpain B-LOC\n) O\n6-4 O\n6-2 O\n3-6 O\n6-1 O\n\nJim B-PER\nGrabb I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nSandon B-PER\nStolle I-PER\n( O\nAustralia B-LOC\n) O\n6-3 O\n7-5 O\n7-6 O\n( O\n7-4 O\n) O\n\nWomen O\n's O\nsingles O\n\nAlexandra B-PER\nFusai I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nJill B-PER\nCraybas I-PER\n( O\nU.S. B-LOC\n) O\n6-1 O\n2-6 O\n7-5 O\n\nNaoko B-PER\nKijimuta I-PER\n( O\nJapan B-LOC\n) O\nbeat O\nTatyana B-PER\nJecmenica I-PER\n( O\nYugoslavia B-LOC\n) O\n6-3 O\n6-2 O\n\nNathalie B-PER\nDechy I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nChristina B-PER\nSinger I-PER\n( O\nGermany B-LOC\n) O\n6-4 O\n6-0 O\n\nJane B-PER\nChi I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nMaria B-PER\nAntonio I-PER\nSanchez I-PER\nLorenzo I-PER\n( O\nSpain B-LOC\n) O\n6-4 O\n1-6 O\n6-3 O\n\nEls B-PER\nCallens I-PER\n( O\nBelgium B-LOC\n) O\nbeat O\nNicole B-PER\nBradtke I-PER\n( O\nAustralia B-LOC\n) O\n7-6 O\n( O\n7-1 O\n) O\n7-6 O\n( O\n9-7 O\n) O\n\nNatalia B-PER\nBaudone I-PER\n( O\nItaly B-LOC\n) O\nbeat O\nJolene B-PER\nWatanabe I-PER\n( O\nU.S. B-LOC\n) O\n6-4 O\n4-6 O\n7-6 O\n( O\n8-6 O\n) O\n\nAi B-PER\nSugiyama I-PER\n( O\nJapan B-LOC\n) O\nbeat O\nJana B-PER\nKandarr I-PER\n( O\nGermany B-LOC\n) O\n6-2 O\n6-1 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nCUBS B-ORG\nEDGE O\nBRAVES B-ORG\nWITH O\nRUN O\nIN O\nTOP O\nOF O\nNINTH O\n. O\n\nATLANTA B-LOC\n1996-08-25 O\n\nBrian B-PER\nMcRae I-PER\nsingled O\nin O\nTyler B-PER\nHouston I-PER\nin O\nthe O\ntop O\nof O\nthe O\nninth O\ninning O\nto O\nsnap O\na O\ntie O\nas O\nthe O\nChicago B-ORG\nCubs I-ORG\navoided O\na O\nthree-game O\nsweep O\nwith O\n3-2 O\nvictory O\nover O\nthe O\nAtlanta B-ORG\nBraves I-ORG\non O\nSunday O\n. O\n\nThe O\nBraves B-ORG\nscored O\nfour O\nruns O\nin O\nthe O\nninth O\nfor O\na O\n6-5 O\nvictory O\non O\nSaturday O\n. O\n\nKevin B-PER\nFoster I-PER\n( O\n5-2 O\n) O\nwon O\nhis O\nsecond O\nstraight O\nstart O\n, O\nallowing O\ntwo O\nruns O\nand O\nsix O\nhits O\nwith O\ntwo O\nwalks O\nand O\nthree O\nstrikeouts O\nover O\neight O\ninnings O\n. O\n\n\" O\nThe O\nbiggest O\nthing O\nwas O\nmy O\nfastball O\n, O\nI O\nwas O\nable O\nto O\nrotate O\nit O\npretty O\ngood O\n, O\n\" O\nFoster B-PER\nsaid O\n. O\n\" O\n\nAlso O\n, O\nI O\nwas O\nable O\nto O\nkeep O\nmy O\nchangeup O\ndown O\n. O\n\" O\n\nAt O\nColorado B-LOC\n, O\nVinny B-PER\nCastilla I-PER\nhomered O\ntwice O\nand O\ndrove O\nin O\nfour O\nruns O\nand O\nLarry B-PER\nWalker I-PER\nwent O\n3-for-4 O\nwith O\na O\nhomer O\nand O\nthree O\nRBI B-MISC\nas O\nthe O\nColorado B-ORG\nRockies I-ORG\noutslugged O\nthe O\nPittsburgh B-ORG\nPirates I-ORG\n13-9 O\nin O\nthe O\nrubber O\ngame O\nof O\na O\nthree-game O\nseries O\n. O\n\nCastilla B-ORG\n's O\nfirst O\nhomer O\nof O\nthe O\ngame O\n, O\na O\nsolo O\nshot O\nin O\nthe O\nseventh O\noff O\nreliever O\nMarc B-PER\nWilkins I-PER\n( O\n3-1 O\n) O\nextended O\nColorado B-ORG\n's O\nlead O\nto O\n9-7 O\n. O\n\nHe O\nadded O\na O\nthree-run O\nhomer O\nin O\nthe O\neighth O\noff O\nJohn B-PER\nEricks I-PER\nto O\nmake O\nit O\n13-8 O\n. O\n\nAt O\nFlorida B-LOC\n, O\nEdgar B-PER\nRenteria I-PER\n's O\ntwo-out O\nsingle O\nin O\nthe O\nbottom O\nof O\nthe O\nninth O\ninning O\nscored O\nJesus B-PER\nTavarez I-PER\nwith O\nthe O\nwinning O\nrun O\nas O\nthe O\nFlorida B-ORG\nMarlins I-ORG\nedged O\nthe O\nCincinnati B-ORG\nReds I-ORG\n6-5 O\n. O\n\n\" O\nRight O\nafter O\nEdgar B-PER\nmade O\ncontact O\n, O\nI O\nknew O\nI O\nhad O\nto O\nscore O\n, O\n\" O\nsaid O\nTavarez B-PER\n. O\n\" O\n\nI O\nknew O\nI O\nwould O\nscore O\neven O\nif O\nhe O\nfielded O\nit O\ncleanly O\n, O\nhe O\ncould O\nn't O\nthrow O\nme O\nout O\n. O\n\" O\n\n\" O\nEdgar B-PER\nis O\na O\ntremendous O\nplayer O\nright O\nnow O\n, O\n\" O\nsaid O\nFlorida B-ORG\nmanager O\nJohn B-PER\nBoles I-PER\n. O\n\" O\n\nBut O\nI O\nca O\nn't O\nwait O\nto O\nsee O\nhow O\ngood O\nhe O\n'll O\nbe O\nwhen O\nhe O\ngrows O\nup O\n. O\n\" O\n\nIn O\nSan B-LOC\nFrancisco I-LOC\n, O\nOsvaldo B-PER\nFenandez I-PER\nfired O\na O\nseven-hitter O\nand O\nTrenidad B-PER\nHubbard I-PER\nbelted O\na O\ntwo-run O\nhomer O\nas O\nthe O\nSan B-ORG\nFrancisco I-ORG\nGiants I-ORG\nended O\na O\nthree-game O\nlosing O\nstreak O\nby O\ndefeating O\nthe O\nMontreal B-ORG\nExpos I-ORG\n, O\n7-2 O\n. O\n\nFernandez B-PER\n( O\n6-13 O\n) O\nallowed O\ntwo O\nruns O\n, O\nwalked O\none O\nand O\nstruck O\nout O\neight O\nfor O\nhis O\nsecond O\ncareer O\ncomplete O\ngame O\n, O\nboth O\nagainst O\nMontreal B-ORG\n. O\n\nIn O\nLos B-LOC\nAngeles I-LOC\n, O\nGreg B-PER\nGagne I-PER\nhad O\na O\nrun-scoring O\nsingle O\nand O\nChad B-PER\nCurtis I-PER\ndrew O\na O\nbases-loaded O\nwalk O\nin O\nthe O\nbottom O\nof O\nthe O\neighth O\ninning O\nas O\nthe O\nLos B-ORG\nAngeles I-ORG\nDodgers I-ORG\nrallied O\nfor O\na O\n6-5 O\nvictory O\nand O\na O\nthree-game O\nsweep O\nof O\nthe O\nNew B-ORG\nYork I-ORG\nMets I-ORG\n. O\n\n\" O\nIt O\nwas O\none O\nof O\nthese O\ngames O\nwhere O\nyou O\nget O\nthree O\nstraight O\npinch-hits O\nand O\na O\nwalk O\nof O\na O\npinch-hitter O\n, O\nthat O\n's O\nhow O\nyou O\nwin O\npennants O\n, O\n\" O\nDodgers B-ORG\nmanager O\nBill B-PER\nRussell I-PER\nsaid O\n. O\n\" O\n\nMike B-PER\nPiazza I-PER\n\nIn O\nSan B-LOC\nDiego I-LOC\n, O\nSteve B-PER\nFinley I-PER\nand O\nJody B-PER\nReed I-PER\ndrove O\nin O\nthree O\nruns O\napiece O\nas O\nthe O\nSan B-ORG\nDiego I-ORG\nPadres I-ORG\nbuilt O\na O\nsix-run O\nlead O\nafter O\nthree O\ninnings O\nand O\ncruised O\nto O\nan O\n11-2 O\nvictory O\nover O\nthe O\nPhiladelphia B-ORG\nPhillies I-ORG\n. O\n\nKen B-PER\nCaminiti I-PER\nadded O\ntwo O\nRBI B-MISC\nfor O\nthe O\nPadres B-ORG\n, O\nwho O\nhave O\nwon O\nsix O\nof O\ntheir O\nlast O\nseven O\ngames O\nand O\nremained O\none O\ngame O\nahead O\nof O\nthe O\nLos B-ORG\nAngeles I-ORG\nDodgers I-ORG\nin O\nthe O\nNational B-MISC\nLeague I-MISC\nWest I-MISC\n. O\n\nIn O\nHouston B-LOC\n, O\nJeff B-PER\nBagwell I-PER\nhomered O\nand O\nDonne B-PER\nWall I-PER\nallowed O\none O\nrun O\nover O\nseven O\ninnings O\nas O\nthe O\nHouston B-ORG\nAstros I-ORG\ndefeated O\nthe O\nSt. B-ORG\nLouis I-ORG\nCardinals I-ORG\n4-1 O\n. O\n\nWall B-PER\n( O\n8-4 O\n) O\nallowed O\nthree O\nhits O\n, O\nwalked O\ntwo O\nand O\nstruck O\nout O\nseven O\nas O\nthe O\nAstros B-ORG\nmoved O\n1-1/2 O\ngames O\nahead O\nof O\nthe O\nCardinals B-ORG\nfor O\nthe O\nlead O\nin O\nthe O\nNational B-MISC\nLeague I-MISC\nCentral I-MISC\n. O\n\nHe O\nleft O\nthe O\ngame O\nwith O\na O\nknot O\nin O\nhis O\nright O\nshoulder O\n. O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nSUNDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-25 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nSunday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n74 O\n55 O\n.574 O\n- O\n\nBALTIMORE B-ORG\n68 O\n61 O\n.527 O\n6 O\n\nBOSTON B-ORG\n66 O\n65 O\n.504 O\n9 O\n\nTORONTO B-ORG\n61 O\n70 O\n.466 O\n14 O\n\nDETROIT B-ORG\n47 O\n83 O\n.362 O\n27 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n77 O\n53 O\n.592 O\n- O\n\nCHICAGO B-ORG\n70 O\n62 O\n.530 O\n8 O\n\nMINNESOTA B-ORG\n65 O\n65 O\n.500 O\n12 O\n\nMILWAUKEE B-ORG\n62 O\n69 O\n.473 O\n15 O\n1/2 O\n\nKANSAS B-ORG\nCITY I-ORG\n59 O\n73 O\n.447 O\n19 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n75 O\n56 O\n.573 O\n- O\n\nSEATTLE B-ORG\n66 O\n63 O\n.512 O\n8 O\n\nOAKLAND B-ORG\n63 O\n70 O\n.474 O\n13 O\n\nCALIFORNIA B-ORG\n61 O\n69 O\n.469 O\n13 O\n1/2 O\n\nMONDAY O\n, O\nAUGUST O\n26TH O\nSCHEDULE O\n\nCLEVELAND B-ORG\nAT O\nDETROIT B-LOC\n\nOAKLAND B-ORG\nAT O\nBALTIMORE B-LOC\n\nMINNESOTA B-ORG\nAT O\nTORONTO B-LOC\n\nMILWAUKEE B-ORG\nAT O\nCHICAGO B-LOC\n\nBOSTON B-ORG\nAT O\nCALIFORNIA B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nSEATTLE B-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n81 O\n48 O\n.628 O\n- O\n\nMONTREAL B-ORG\n70 O\n59 O\n.543 O\n11 O\n\nFLORIDA B-ORG\n61 O\n70 O\n.466 O\n21 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n72 O\n.450 O\n23 O\n\nPHILADELPHIA B-ORG\n53 O\n78 O\n.405 O\n29 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nHOUSTON B-ORG\n70 O\n61 O\n.534 O\n- O\n\nST B-ORG\nLOUIS I-ORG\n68 O\n62 O\n.523 O\n1 O\n1/2 O\n\nCHICAGO B-ORG\n64 O\n64 O\n.500 O\n4 O\n1/2 O\n\nCINCINNATI B-ORG\n64 O\n65 O\n.496 O\n5 O\n\nPITTSBURGH B-ORG\n55 O\n75 O\n.423 O\n14 O\n1/2 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n72 O\n60 O\n.545 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n70 O\n60 O\n.538 O\n1 O\n\nCOLORADO B-ORG\n68 O\n63 O\n.519 O\n3 O\n1/2 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n55 O\n73 O\n.430 O\n15 O\n\nMONDAY O\n, O\nAUGUST O\n26TH O\nSCHEDULE O\n\nPHILADELPHIA B-ORG\nAT O\nSAN B-LOC\nFRANCISCO I-LOC\n\nST B-ORG\nLOUIS I-ORG\nAT O\nHOUSTON B-LOC\n\nCINCINNATI B-ORG\nAT O\nCOLORADO B-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nBONDS B-PER\n' O\nCONSECUTIVE O\nGAME O\nSTREAK O\nENDS O\n. O\n\nSAN B-LOC\nFRANCISCO I-LOC\n1996-08-25 O\n\nSan B-ORG\nFrancisco I-ORG\nGiants I-ORG\nAll-Star B-MISC\nleft O\nfielder O\nBarry B-PER\nBonds I-PER\ndid O\nnot O\nappear O\nin O\nSunday O\n's O\n7-2 O\nvictory O\nover O\nthe O\nMontreal B-ORG\nExpos I-ORG\n, O\nending O\nhis O\nconsecutive O\ngames O\nstreak O\n. O\n\nAfter O\nappearing O\nas O\na O\npinch-hitter O\nin O\nthe O\nprevious O\ntwo O\ngames O\n, O\nBonds B-PER\n, O\nwho O\nhas O\nbeen O\nbattling O\na O\nhamstring O\ninjury O\n, O\ndid O\nnot O\nsee O\nany O\naction O\ntoday O\n, O\nending O\nhis O\nstreak O\nat O\n357 O\nconsecutive O\ngames O\n. O\n\nIt O\nwas O\nthe O\nsecond-longest O\nstreak O\nby O\nan O\nactive O\nplayer O\nin O\nthe O\nthe O\nmajors O\nbehind O\nBaltimore B-ORG\n's O\nCal B-PER\nRipken I-PER\n, O\nwho O\nappeared O\nin O\nhis O\nmajor-league O\nrecord O\n2,282nd O\nstraight O\ngame O\ntoday O\n, O\na O\n13-0 O\nloss O\nto O\nthe O\nCalifornia B-ORG\nAngels I-ORG\n. O\n\nBonds B-PER\nhas O\nbeen O\nlimited O\nto O\na O\npinch-hitting O\nrole O\nsince O\nan O\nMRI B-MISC\nFriday O\nshowed O\na O\nmild O\nstrain O\nof O\nhis O\nleft O\nhamstring O\n. O\n\nBonds B-PER\ncame O\nout O\nof O\nWednesday O\n's O\ngame O\nagainst O\nNew B-ORG\nYork I-ORG\nin O\nthe O\nninth O\ninning O\nafter O\nsuffering O\na O\nmild O\nhamstring O\nstrain O\n. O\n\nHe O\nwas O\nback O\nin O\nthe O\nstarting O\nlineup O\nThursday O\nnight O\nand O\nwent O\n1-for-2 O\nbefore O\nexiting O\nin O\nthe O\nthird O\ninning O\n. O\n\nThe O\n32-year-old O\nBonds B-PER\nis O\nhitting O\n.307 O\nwith O\n35 O\nhomers O\nand O\n107 O\nRBI B-MISC\nand O\nhas O\nbeen O\none O\nof O\nthe O\nfew O\nbright O\nspots O\nfor O\nthe O\nlast-place O\nGiants B-ORG\n. O\n\nChicago B-ORG\nCubs I-ORG\noutfielder O\nSammy B-PER\nSosa I-PER\nhad O\nthe O\nthird-longest O\nstreak O\nat O\n304 O\ngames O\n, O\nbut O\nthat O\nended O\nearlier O\nthis O\nweek O\nwhen O\nhe O\nsuffered O\na O\nbroken O\nbone O\nin O\nhis O\nright O\nhand O\n. O\n\nAtlanta B-ORG\nBraves I-ORG\nfirst O\nbaseman O\nFred B-PER\nMcGriff I-PER\nowns O\nthe O\nsecond-longest O\nstreak O\nat O\n295 O\ngames O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nJONK B-PER\nRETURNS O\nTO O\nDUTCH B-MISC\nSQUAD O\nFOR O\nBRAZIL B-LOC\nFRIENDLY O\n. O\n\nROTTERDAM B-LOC\n1996-08-26 O\n\nDutch B-MISC\ncoach O\nGuus B-PER\nHiddink I-PER\non O\nMonday O\nrecalled O\nmidfielder O\nWim B-PER\nJonk I-PER\nafter O\na O\n14-month O\nabsence O\nfor O\na O\nfriendly O\nagainst O\nWorld B-MISC\nCup I-MISC\nholders O\nBrazil B-LOC\nin O\nAmsterdam B-LOC\non O\nSunday O\n. O\n\nFeyenoord B-ORG\nmidfielder O\nJean-Paul B-PER\nvan I-PER\nGastel I-PER\nwas O\nalso O\nnamed O\nto O\nmake O\nhis O\ndebut O\nin O\nthe O\n18-man O\nsquad O\n. O\n\nHiddink B-PER\ndid O\nnot O\nname O\na O\nreplacement O\ncaptain O\nfor O\nDanny B-PER\nBlind I-PER\n, O\nwho O\nannounced O\nhis O\nretirement O\nfrom O\ninternational O\nsoccer O\non O\nSunday O\n. O\n\nRonald B-PER\nde I-PER\nBoer I-PER\nand O\nDennis B-PER\nBergkamp I-PER\nare O\nthe O\nlikely O\ncontenders O\nto O\nlead O\nthe O\nteam O\n. O\n\nThe O\n35-year-old O\nBlind B-PER\n, O\nwho O\nwon O\n42 O\ncaps O\nfor O\nthe O\nNetherlands B-LOC\n, O\nsaid O\nhe O\nwanted O\nto O\nconcentrate O\non O\nplaying O\nfor O\nhis O\nDutch B-MISC\nclub O\nAjax B-ORG\nAmsterdam I-ORG\n. O\n\nAC B-ORG\nMilan I-ORG\nmidfielder O\nEdgar B-PER\nDavids I-PER\n, O\nwho O\nwas O\nsent O\nhome O\nearly O\nfrom O\nthe O\nEuropean B-MISC\nchampionship O\nin O\nEngland B-LOC\nafter O\na O\nclash O\nwith O\nthe O\ncoach O\n, O\nwas O\nleft O\nout O\nof O\nthe O\nsquad O\n. O\n\nSquad O\n: O\n\nGoalkeepers O\n- O\nEdwin B-PER\nvan I-PER\nder I-PER\nSar I-PER\n( O\nAjax B-ORG\n) O\n, O\nEd B-PER\nde I-PER\nGoey I-PER\n( O\nFeyenoord B-ORG\n) O\n. O\n\nDefenders O\n- O\nFrank B-PER\nde I-PER\nBoer I-PER\n( O\nAjax B-ORG\n) O\n, O\nJohn B-PER\nVeldman I-PER\n( O\nAjax B-ORG\n) O\n, O\nJaap B-PER\nStam I-PER\n( O\nPSV B-ORG\n) O\n, O\nArthur B-PER\nNuman I-PER\n( O\nPSV B-ORG\n) O\n, O\nMichael B-PER\nReiziger I-PER\n( O\nAC B-ORG\nMilan I-ORG\n) O\n, O\nJohan B-PER\nde I-PER\nKock I-PER\n( O\nSchalke B-ORG\n' O\n04 O\n) O\n. O\n\nMidfielders O\n- O\nRichard B-PER\nWitschge I-PER\n( O\nAjax B-ORG\n) O\n, O\nPhilip B-PER\nCocu I-PER\n( O\nPSV B-ORG\n) O\n, O\nWim B-PER\nJonk I-PER\n( O\nPSV B-ORG\n) O\n, O\nAron B-PER\nWinter I-PER\n( O\nInternazionale B-ORG\n) O\n, O\nJean-Paul B-PER\nvan I-PER\nGastel I-PER\n( O\nFeyenoord B-ORG\n) O\n, O\nClarence B-PER\nSeedorf I-PER\n( O\nReal B-ORG\nMadrid I-ORG\n) O\n. O\n\nStrikers O\n- O\nRonald B-PER\nde I-PER\nBoer I-PER\n( O\nAjax B-ORG\n) O\n, O\nGaston B-PER\nTaument I-PER\n( O\nFeyenoord B-ORG\n) O\n, O\nJordi B-PER\nCruyff I-PER\n( O\nManchester B-ORG\nUnited I-ORG\n) O\n, O\nDennis B-PER\nBergkamp I-PER\n( O\nArsenal B-ORG\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBARCELONA B-ORG\nBEAT O\nATLETICO B-ORG\n5-2 O\nIN O\nSUPERCUP B-MISC\n. O\n\nBARCELONA B-LOC\n1996-08-26 O\n\nBarcelona B-ORG\nbeat O\nAtletico B-ORG\nMadrid I-ORG\n5-2 O\n( O\nhalftime O\n2-1 O\n) O\nin O\nthe O\nSpanish B-MISC\nSupercup I-MISC\non O\nSunday O\n: O\n\nScorers O\n: O\n\nBarcelona B-ORG\n- O\nRonaldo B-PER\n( O\n5th O\nand O\n89th O\nminutes O\n) O\n, O\nGiovanni B-PER\n( O\n31st O\n) O\n, O\nPizzi B-PER\n( O\n73rd O\n) O\n, O\nDe B-PER\nla I-PER\nPena I-PER\n( O\n75th O\n) O\n\nAtletico B-ORG\nMadrid I-ORG\n- O\nEsnaider B-PER\n( O\n37th O\n) O\n, O\nPantic B-PER\n( O\n57th O\n, O\npenalty O\n) O\n\nAttendance O\n30,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nAUSTRIA B-LOC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nVIENNA B-LOC\n1996-08-26 O\n\nResult O\nof O\nan O\nAustrian B-MISC\nfirst O\n\ndivision O\nsoccer O\nmatch O\nplayed O\non O\nSunday O\n: O\n\nSV B-ORG\nRied I-ORG\n0 O\nSV B-ORG\nSalzburg I-ORG\n4 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nFC B-ORG\nTirol I-ORG\nInnsbruck I-ORG\n6 O\n4 O\n2 O\n0 O\n13 O\n5 O\n14 O\n\nSV B-ORG\nSalzburg I-ORG\n6 O\n4 O\n2 O\n0 O\n8 O\n1 O\n14 O\n\nAustria B-ORG\nVienna I-ORG\n6 O\n4 O\n2 O\n0 O\n9 O\n5 O\n14 O\n\nSturm B-ORG\nGraz I-ORG\n6 O\n2 O\n3 O\n1 O\n8 O\n5 O\n9 O\n\nGAK B-ORG\n6 O\n1 O\n3 O\n2 O\n8 O\n10 O\n6 O\n\nRapid B-ORG\nWien I-ORG\n5 O\n0 O\n5 O\n0 O\n3 O\n3 O\n5 O\n\nSV B-ORG\nRied I-ORG\n6 O\n1 O\n1 O\n4 O\n6 O\n9 O\n4 O\n\nLinzer B-ORG\nASK I-ORG\n5 O\n0 O\n3 O\n2 O\n4 O\n8 O\n3 O\n\nAdmira B-ORG\n/ I-ORG\nWacker I-ORG\n6 O\n0 O\n3 O\n3 O\n5 O\n10 O\n3 O\n\nFC B-ORG\nLinz I-ORG\n6 O\n0 O\n2 O\n4 O\n1 O\n9 O\n2 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nAUSTRALIA B-LOC\nBEAT O\nZIMBABWE B-LOC\nBY O\n125 O\nRUNS O\nIN O\nONE-DAY O\nMATCH O\n. O\n\nCOLOMBO B-LOC\n1996-08-26 O\n\nAustralia B-LOC\nbeat O\nZimbabwe B-LOC\nby O\n125 O\nruns O\nin O\nthe O\nfirst O\nmatch O\nof O\nthe O\nSinger B-MISC\nWorld I-MISC\nSeries I-MISC\none-day O\n( O\n50 O\novers O\n) O\ncricket O\ntournament O\non O\nMonday O\n. O\n\nScores O\n: O\nAustralia B-LOC\n263-7 O\nin O\n50 O\novers O\n, O\nZimbabwe B-LOC\n138 O\nall O\nout O\nin O\n41 O\novers O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nSCOREBOARD-AUSTRALIA B-MISC\nV O\nZIMBABWE B-LOC\nONE-DAY O\nSCOREBOARD O\n. O\n\nCOLOMBO B-LOC\n1996-08-26 O\n\nScoreboard O\nin O\nthe O\nSinger B-MISC\nWorld I-MISC\n\nSeries B-MISC\none-day O\n( O\n50 O\novers O\n) O\ncricket O\nmatch O\nbetween O\nAustralia B-LOC\nand O\n\nZimbabwe B-LOC\non O\nMonday O\n: O\n\nAustralia B-LOC\n\nM. B-PER\nSlater I-PER\nc O\nP. B-PER\nStrang I-PER\nb O\nWhittall B-PER\n50 O\n\nM. B-PER\nWaugh I-PER\nb O\nP. B-PER\nStrang I-PER\n18 O\n\nR. B-PER\nPonting I-PER\nc O\nand O\nb O\nWhittall B-PER\n53 O\n\nS. B-PER\nWaugh I-PER\nc O\nCampbell B-PER\nb O\nWhittall B-PER\n82 O\n\nS. B-PER\nLaw I-PER\nb O\nStreak B-PER\n20 O\n\nM. B-PER\nBevan I-PER\nc O\nCampbell B-PER\nb O\nBrandes B-PER\n9 O\n\nI. B-PER\nHealy I-PER\nb O\nBrandes B-PER\n5 O\n\nB. B-PER\nHogg I-PER\nnot O\nout O\n11 O\n\nExtras O\n( O\nb-1 O\nlb-8 O\nw-3 O\nnb-3 O\n) O\n15 O\n\nTotal O\n( O\nfor O\nseven O\nwickets O\n- O\n50 O\novers O\n) O\n263 O\n\nFall O\nof O\nwickets O\n: O\n1-48 O\n2-92 O\n3-167 O\n4-230 O\n5-240 O\n6-242 O\n7-263 O\n\nDid O\nnot O\nbat O\n: O\nP. B-PER\nReiffel I-PER\n, O\nD. B-PER\nFlemming I-PER\n, O\nG. B-PER\nMcGrath I-PER\n\nBowling O\n: O\nStreak B-PER\n10-1-50-1 O\n( O\n2w O\n, O\n2nb O\n) O\n, O\nBrandes B-PER\n10-1-47-2 O\n( O\n1w O\n) O\n, O\n\nP. B-PER\nStrang I-PER\n9-0-41-1 O\n, O\nFlower B-PER\n6-0-28-0 O\n, O\nWhittall B-PER\n10-0-53-3 O\n( O\n1nb O\n) O\n, O\n\nDecker B-PER\n3-0-17-0 O\n, O\nShah B-PER\n2-0-18-0 O\n\nZimbabwe B-LOC\n\nA. B-PER\nShah I-PER\nc O\nM. B-PER\nWaugh I-PER\nb O\nHogg B-PER\n41 O\n\nG. B-PER\nFlower I-PER\nc O\nPonting B-PER\nb O\nFlemming B-PER\n7 O\n\nA. B-PER\nFlower I-PER\nlbw O\nb O\nFlemming B-PER\n0 O\n\nA. B-PER\nCampbell I-PER\nlbw O\nb O\nMcGrath B-PER\n9 O\n\nC. B-PER\nWishart I-PER\nc O\nHealy B-PER\nb O\nReiffel B-PER\n0 O\n\nG. B-PER\nWhittall I-PER\nb O\nReiffel B-PER\n11 O\n\nC. B-PER\nEvans I-PER\nc O\nHealy B-PER\nb O\nS. B-PER\nWaugh I-PER\n15 O\n\nM. B-PER\nDekker I-PER\nnot O\nout O\n8 O\n\nP. B-PER\nStrang I-PER\nb O\nM. B-PER\nWaugh I-PER\n9 O\n\nH. B-PER\nStreak I-PER\nb O\nM. B-PER\nWaugh I-PER\n0 O\n\nE. B-PER\nBrandes I-PER\nc O\nHogg B-PER\nb O\nM. B-PER\nWaugh I-PER\n17 O\n\nExtras O\n( O\nlb-4 O\nw-10 O\nnb-7 O\n) O\n21 O\n\nTotal O\n( O\nall O\nout O\n- O\n41 O\novers O\n) O\n138 O\n\nFall O\nof O\nwickets O\n: O\n1-16 O\n2-16 O\n3-33 O\n4-35 O\n5-56 O\n6-98 O\n7-100 O\n8-120 O\n\n9-120 O\n\nBowling O\n: O\nMcGrath B-PER\n7-2-13-1 O\n( O\n2w O\n) O\n, O\nFlemming B-PER\n7-0-24-2 O\n( O\n3w O\n, O\n3nb O\n) O\n, O\n\nReiffel B-PER\n6-1-23-2 O\n( O\n2nb O\n) O\n, O\nS. B-PER\nWaugh I-PER\n7-2-24-1 O\n( O\n1nb O\n, O\n2w O\n) O\n, O\nHogg B-PER\n\n9-2-26-1 O\n( O\n1nb O\n, O\n3w O\n) O\n, O\nM. B-PER\nWaugh I-PER\n5-1-24-3 O\n\nResult O\n: O\nAustralia B-LOC\nwon O\nby O\n125 O\nruns O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nAUSTRALIA B-LOC\n263-7 O\nIN O\n50 O\nOVERS O\nV O\nZIMBABWE B-LOC\n. O\n\nCOLOMBO B-LOC\n1996-08-26 O\n\nAustralia B-LOC\nscored O\n263-7 O\nin O\ntheir O\n50 O\novers O\nagainst O\nZimbabwe B-LOC\nin O\nthe O\nfirst O\nday-night O\nlimited O\novers O\nmatch O\nof O\nthe O\nSinger B-MISC\nWorld I-MISC\nSeries I-MISC\ntournament O\non O\nMonday O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nAUSTRALIA B-LOC\nWIN O\nTOSS O\n, O\nOPT O\nTO O\nBAT O\nAGAINST O\nZIMBABWE B-LOC\n. O\n\nCOLOMBO B-LOC\n1996-08-26 O\n\nAustralia B-LOC\nwon O\nthe O\ntoss O\nand O\ndecided O\nto O\nbat O\nagainst O\nZimbabwe B-LOC\nin O\nthe O\nfirst O\nday-night O\nlimited O\novers O\nmatch O\nof O\nthe O\nSinger B-MISC\nWorld I-MISC\nSeries I-MISC\ntournament O\non O\nMonday O\n. O\n\nTeams O\n: O\n\nAustralia B-LOC\n- O\nMark B-PER\nWaugh I-PER\n, O\nMichael B-PER\nSlater I-PER\n, O\nRicky B-PER\nPonting I-PER\n, O\nSteve B-PER\nWaugh I-PER\n, O\nStuart B-PER\nLaw I-PER\n, O\nMichael B-PER\nBevan I-PER\n, O\nIan B-PER\nHealy I-PER\n( O\ncaptain O\n) O\n, O\nBrad B-PER\nHogg I-PER\n, O\nPaul B-PER\nReiffel I-PER\n, O\nDamein B-PER\nFleming I-PER\n, O\nGlenn B-PER\nMcGrath I-PER\n. O\n\nZimbabwe B-LOC\n- O\nAlistair B-PER\nCampbell I-PER\n( O\ncaptain O\n) O\n, O\nAndy B-PER\nFlower I-PER\n, O\nGrant B-PER\nFlower I-PER\n, O\nGuy B-PER\nWhittall I-PER\n, O\nCraig B-PER\nEvans I-PER\n, O\nEddo B-PER\nBrandes I-PER\n, O\nHeath B-PER\nStreak I-PER\n, O\nPaul B-PER\nStrang I-PER\n, O\nCraig B-PER\nWishart I-PER\n, O\nAli B-PER\nShah I-PER\n, O\nMark B-PER\nDekker I-PER\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nMOZAMBIQUE B-LOC\n- O\nAUGUST O\n26 O\n. O\n\nMAPUTO B-LOC\n1996-08-26 O\n\nThis O\nis O\nthe O\nleading O\nstory O\nin O\nthe O\nMozambican B-MISC\npress O\non O\nMonday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthis O\nstory O\nand O\ndoes O\nnot O\nvouch O\nfor O\nits O\naccuracy O\n. O\n\nNOTICIAS B-ORG\n\n- O\nAt O\nleast O\n20 O\npeople O\nwere O\nkilled O\nwhen O\nthe O\ntwo O\ntrucks O\nin O\nwhich O\nthey O\nwere O\ntravelling O\ncollided O\nat O\nNhamavila B-LOC\nabout O\n160 O\nkm O\nnorth O\nof O\nMaputo B-LOC\non O\nSaturday O\n, O\nthe O\nMaputo B-LOC\ndaily O\nNoticias B-ORG\nsaid O\n. O\n\n-DOCSTART- O\n\nLamonts B-ORG\nApparel I-ORG\nfiles O\nreorganization O\nplan O\n. O\n\n[ O\nCORRECTED O\n18:00 O\nGMT B-MISC\n] O\n\nKIRKLAND B-LOC\n, O\nWash B-LOC\n. O\n\n1996-08-26 O\n\nLamonts B-ORG\nApparel I-ORG\nInc I-ORG\n, O\nan O\noperator O\nof O\n42 O\nfamily O\napparel O\nstores O\nin O\nsix O\nnorthwestern O\nstates O\n, O\nsaid O\nit O\nhas O\nfiled O\na O\nreorganization O\nplan O\nin O\nbankruptcy O\ncourt O\nin O\nSeattle B-LOC\n. O\n\n( O\nCorrects O\nto O\nmake O\nclear O\na O\nreorganization O\nplan O\nhas O\nbeen O\nfiled O\n) O\n. O\n\nThe O\nreorganization O\nplan O\ncalls O\nfor O\nall O\nsecured O\nclaims O\nto O\nbe O\npaid O\nin O\nfull O\n. O\n\nUnsecured O\nclaims O\n, O\nincluding O\nthose O\nof O\ncompany O\nbondholders O\n, O\nwill O\nbe O\nsatisfied O\nby O\nissuing O\nnew O\ncommon O\nstock O\nand O\nwarrants O\n. O\n\nUnsecured O\nclaims O\nare O\nestimated O\nat O\nabout O\n$ O\n90 O\nmillion O\n. O\n\nLamonts B-ORG\nsaid O\nit O\nplans O\nto O\nissue O\n9 O\nmillion O\nshares O\nof O\nnew O\ncommon O\nstock O\n. O\n\nOf O\nthat O\namount O\n, O\n4.05 O\nmillion O\nand O\n5.67 O\nmillion O\nshares O\nwill O\nbe O\nallocated O\nto O\nthe O\ncompany O\n's O\ntrade O\ncreditors O\n. O\n\nBetween O\n4.75 O\nand O\n3.13 O\nmillion O\nshares O\nwill O\nbe O\nallocated O\nto O\nbondholders O\nand O\nother O\nunsecured O\nnon-trade O\ncreditors O\nand O\n200,000 O\nwill O\nbe O\nallocated O\nto O\nexisting O\nshareholders O\nin O\nexchange O\nfor O\nall O\nexisting O\nstock O\nof O\nthe O\ncompany O\n. O\n\nBondholders O\nand O\nother O\nunsecured O\nnon-trade O\ncreditors O\nwill O\nreceive O\nwarrants O\nfour O\nabout O\n2.2 O\nmillion O\nshares O\nwhen O\nthe O\ncompany O\n's O\nmarket O\ncapitalization O\nreaches O\n$ O\n20 O\nmillion O\n. O\n\nBondholders O\n, O\nother O\nunsecured O\nnon-trade O\ncreditors O\n, O\nand O\nexisting O\nshareholders O\nalso O\nwill O\nreceive O\nwarrants O\nentitling O\nthem O\nto O\nroughly O\n800,000 O\nshares O\nwhen O\nthe O\ncompany O\n's O\nmarket O\ncapitalization O\nreaches O\n$ O\n25 O\nmillion O\n. O\n\nManagement O\nwill O\nreceive O\noptions O\nto O\npurchase O\n10 O\npercent O\nof O\nthe O\ncompany O\n's O\noutstanding O\ncommon O\nstock O\nwith O\nprotection O\nagainst O\ndilution O\nat O\nan O\noption O\nexercise O\nprice O\nof O\n$ O\n1 O\nmillion O\n. O\n\n-DOCSTART- O\n\nPassengers O\nrescued O\nfrom O\nblazing O\nferry O\noff O\nFrance B-LOC\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nMore O\nthan O\n100 O\npeople O\nwere O\nsafely O\nevacuated O\non O\nMonday O\nfrom O\na O\nferry O\nthat O\ncaught O\nfire O\nsoon O\nafter O\nleaving O\nGuernsey B-LOC\nin O\nBritain B-LOC\n's O\nChannel B-LOC\nIslands I-LOC\n, O\npolice O\nsaid O\n. O\n\nPolice O\nsaid O\nthe O\n111 O\npassengers O\nand O\nsix O\ncrew O\non O\nboard O\nthe O\nferry O\nTrident B-MISC\nSeven I-MISC\n, O\nowned O\nby O\nFrance B-LOC\n's O\nEmeraud B-ORG\nline O\n, O\nwere O\nrescued O\nby O\na O\nvariety O\nof O\nprivate O\nand O\ncommercial O\nboats O\nafter O\nfire O\nbroke O\nout O\nin O\nthe O\nengine O\nroom O\nsoon O\nafter O\nit O\nleft O\nport O\n. O\n\nAn O\n88-year-old O\nwoman O\nwas O\ntaken O\nto O\nhospital O\nwith O\nleg O\ninjuries O\n, O\naccording O\nto O\na O\nspokesman O\nfor O\nGuernsey B-LOC\npolice O\n. O\n\nThe O\nferry O\n, O\nwhich O\nwas O\ntowed O\ninto O\nport O\n, O\nhad O\nbeen O\nbound O\nfor O\nJersey B-LOC\n, O\nanother O\nin O\na O\ncluster O\nof O\nsmall O\nBritish-ruled B-MISC\nislands O\noff O\nnorth-west O\nFrance B-LOC\n. O\n\n-DOCSTART- O\n\nOSCE B-ORG\ndelays O\ndecision O\non O\nrefugee O\nvoting O\n. O\n\nKurt B-PER\nSchork I-PER\n\nSARAJEVO B-LOC\n1996-08-26 O\n\nBosnia B-LOC\n's O\nelection O\norganisers O\nwill O\ndecide O\non O\nTuesday O\nwhether O\nor O\nnot O\nto O\npostpone O\nmunicipal O\nelections O\nscheduled O\nas O\npart O\nof O\nnationwide O\nballoting O\n, O\nan O\nOSCE B-ORG\nspokeswoman O\nsaid O\non O\nMonday O\n. O\n\nOfficials O\nfrom O\nthe O\nOrganisation B-ORG\nfor I-ORG\nSecurity I-ORG\nand I-ORG\nCooperation I-ORG\nin I-ORG\nEurope I-ORG\n( O\nOSCE B-ORG\n) O\nare O\nconsidering O\nthe O\npostponement O\nfollowing O\nallegations O\nof O\nserious O\nirregularities O\nin O\nthe O\nregistration O\nof O\nSerb B-MISC\nrefugees O\n. O\n\nInternational O\nobservers O\nsay O\nthe O\nalleged O\nirregularities O\ncould O\naffect O\nthe O\noutcome O\nof O\nvoting O\nfor O\nmunicipal O\nassemblies O\n. O\n\n\" O\nTomorrow O\n... O\n\nthe O\nProvisional B-ORG\nElection I-ORG\nCommission I-ORG\nwill O\nconsider O\nthe O\npossible O\npostponement O\nof O\nmunicipal O\nelections O\nonly O\n... O\n\nthe O\nother O\nelections O\nwill O\nbe O\nheld O\non O\nSeptember O\n14 O\n, O\n\" O\nOSCE B-ORG\nspokeswoman O\nAgota B-PER\nKuperman I-PER\ntold O\nreporters O\nin O\nSarajevo B-LOC\n. O\n\n\" O\nI O\nthink O\nthat O\nit O\nwould O\nbe O\nvery O\ndifficult O\nto O\nselect O\nwhich O\nmunicipal O\nelections O\nwould O\nhave O\nto O\nbe O\ncancelled O\n. O\n\nI O\nthink O\nprobably O\nif O\nthe O\ndecision O\n( O\nto O\ncancell O\n) O\nwere O\nto O\nbe O\ntaken O\nit O\nwould O\nprobably O\nbe O\nall O\nmunicipal O\nelections O\n.. O\n\n. O\n\" O\n\nKuperman B-PER\nadded O\nthat O\noptions O\nother O\nthan O\npostponement O\nwere O\nalso O\non O\nthe O\ntable O\n, O\nbut O\nshe O\nrefused O\nto O\nspecify O\nwhat O\nthey O\nwere O\n. O\n\nThe O\nDayton B-LOC\npeace O\nagreement O\ngave O\nthe O\nOSCE B-ORG\na O\nmandate O\nto O\norganise O\nBosnian B-MISC\nelections O\n. O\n\nThe O\nProvisional B-ORG\nElection I-ORG\nCommission I-ORG\nis O\nOSCE B-ORG\n's O\ntop O\nrule-making O\nbody O\nfor O\nthe O\npoll O\n. O\n\nMore O\nthan O\n600,000 O\nrefugees O\nhave O\nregistered O\nto O\nvote O\nin O\n55 O\ncountries O\naround O\nthe O\nworld O\n, O\nrepresenting O\nabout O\n20 O\nper O\ncent O\nof O\nBosnia B-LOC\n's O\ntotal O\nelectorate O\n. O\n\nThey O\nare O\ndue O\nto O\nbegin O\nvoting O\non O\nWednesday O\n, O\nAugust O\n28 O\n, O\njust O\none O\nday O\nafter O\nthe O\nPEC B-ORG\nis O\nsupposed O\nto O\nmake O\nits O\ndecision O\n. O\n\nBalloting O\ninside O\nBosnia B-LOC\nis O\nscheduled O\nfor O\nSeptember O\n14 O\n, O\nwhen O\ncitizens O\nare O\nslated O\nto O\nelect O\nmunicipal O\nand O\ncantonal O\nassemblies O\n, O\nseparate O\nMoslem-Croat B-MISC\nand O\nSerb B-MISC\nparliaments O\n, O\na O\nnational O\nHouse B-ORG\nof I-ORG\nRepresentatives I-ORG\nand O\na O\nthree-man O\nPresidency O\n. O\n\nA O\nSarajevo B-LOC\ndaily O\nnewspaper O\n, O\nDnevi B-ORG\nAvaz I-ORG\n, O\nwhich O\nis O\nclose O\nto O\nBosnia B-LOC\n's O\nMoslem B-MISC\nnationalist O\nSDA B-ORG\nparty O\n, O\non O\nMonday O\nsaid O\nthe O\nOSCE B-ORG\nwould O\npostpone O\nthe O\nmunicipal-level O\nelections O\nuntil O\nthe O\nSpring O\nof O\n1997 O\nbecause O\nof O\nthe O\nrefugee O\nregistration O\nproblems O\n. O\n\nSDA B-ORG\nhas O\na O\nrepresentative O\non O\nthe O\nProvisional B-ORG\nElection I-ORG\nCommission I-ORG\n. O\n\n\" O\nI O\ndo O\nn't O\nknow O\nwhat O\nthe O\nsource O\nof O\nthe O\nDnevi B-ORG\nAvaz I-ORG\nreport O\nis O\n, O\nbut O\nit O\nis O\nconsistent O\nwith O\nwhat O\nI O\nhave O\nheard O\nfrom O\nwestern O\ndiplomats O\nand O\nfrom O\ninside O\nthe O\nOSCE B-ORG\n, O\n\" O\nsaid O\nan O\nOSCE B-ORG\nstaff O\nmember O\nin O\nSarajevo B-LOC\nwho O\nasked O\nnot O\nto O\nbe O\nnamed O\n. O\n\n\" O\nThe O\nword O\nis O\nthat O\nFrowick B-PER\nhas O\ndecided O\nto O\npostpone O\nmunicipal O\nelections O\nbut O\nthat O\nhe O\nwill O\nwait O\nfor O\none O\nmore O\nsession O\nof O\nthe O\nPEC B-ORG\non O\nTuesday O\nto O\ntake O\neveryone O\n's O\ntemperature O\non O\nthe O\nissue O\n. O\n\" O\n\nAmbassador O\nRobert B-PER\nFrowick I-PER\n, O\nan O\nAmerican B-MISC\n, O\nheads O\nthe O\nOSCE B-ORG\nmission O\nin O\nBosnia B-LOC\n. O\n\nOSCE B-ORG\nand O\nindependent O\nmonitors O\nallege O\nthat O\nSerb B-MISC\nauthorities O\nhave O\nsystematically O\ndiscouraged O\nrefugees O\nfrom O\nregistering O\nto O\ncast O\na O\nballot O\nin O\nthe O\nplaces O\nthey O\nlived O\nbefore O\nthe O\nwar O\n. O\n\nInstead O\n, O\nthe O\nrefugees O\nwere O\nsaid O\nto O\nhave O\nbeen O\ndirected O\nby O\ntheir O\nauthorities O\nto O\nvote O\nfrom O\nstrategic O\ntowns O\nwhich O\nhad O\nMoslem B-MISC\nmajorities O\nbefore O\nthe O\n43-month O\nBosnian B-MISC\nwar O\n, O\nbut O\nwhich O\nare O\nnow O\nunderpopulated O\nas O\na O\nresult O\nof O\n\" O\nethnic O\ncleansing O\n\" O\n. O\n\nDiplomats O\nexplain O\nthe O\npurpose O\nof O\nthis O\nelectoral O\nengineering O\nis O\nto O\nsecure O\nSerb B-MISC\ncontrol O\nover O\npivotal O\ntowns O\ninside O\nthe O\n49 O\nper O\ncent O\nof O\nBosnia B-LOC\nknown O\nas O\nthe O\nSerb B-MISC\nrepublic O\n, O\nconsolidating O\nthrough O\nthe O\nballot O\nbox O\nwhat O\nwas O\ninitially O\ntaken O\nin O\nwar O\n. O\n\nThe O\ntop O\nU.N. B-ORG\nrefugee O\nofficial O\nin O\nthe O\nBalkans B-LOC\nhighlighted O\nthe O\nvoter O\nregistration O\nproblem O\non O\nMonday O\n. O\n\n\" O\nResults O\nof O\nthe O\nregistration O\nfor O\nSeptember O\nelections O\nherald O\na O\ndismal O\nfuture O\nfor O\nmulti-ethnicity O\nin O\nBosia-Hercegovina B-LOC\n, O\n\" O\nwarned O\nSoren B-PER\nJessen-Petersen I-PER\n, O\nSpecial O\nEnvoy O\nfor O\nthe O\nU.N. B-ORG\nHigh O\nCommissioner O\nfor O\nRefugees O\nin O\nFormer B-LOC\nYugoslavia I-LOC\n. O\n\n\" O\nIn O\nthe O\nrun-up O\nto O\nelections O\n, O\nnationalistic O\npolitical O\nleaders O\nare O\nplaying O\nthe O\nethnic O\n/ O\nsectarian O\ncard O\n, O\ndrumming O\nup O\nsupport O\nwithin O\ntheir O\nconstituencies O\nby O\nplaying O\non O\nbitter O\nmemories O\nor O\nfear O\n. O\n\" O\n\n-DOCSTART- O\n\nAfter O\ntruce O\n, O\nLebed B-PER\nfaces O\ntougher O\nChechen B-MISC\nproblem O\n. O\n\nAlastair B-PER\nMacdonald I-PER\n\nMOSCOW B-LOC\n1996-08-26 O\n\nAlexander B-PER\nLebed I-PER\nmay O\nfinally O\nget O\nto O\ndiscuss O\nhis O\nChechen B-MISC\npeace O\nproposals O\nwith O\nBoris B-PER\nYeltsin I-PER\non O\nTuesday O\nafter O\na O\nlost O\nweekend O\nin O\nthe O\nregion O\nwhen O\nhe O\nwas O\nforced O\nto O\nabandon O\nplans O\nto O\nsign O\na O\nnew O\npolitical O\ntreaty O\nwith O\nthe O\nseparatist O\nrebels O\n. O\n\nIt O\ncould O\nbe O\na O\nsobering O\nexperience O\nfor O\nthe O\nKremlin B-LOC\nsecurity O\nchief O\nwho O\n, O\njust O\ntwo O\nmonths O\nafter O\nbeing O\nappointed O\nby O\nthe O\npresident O\nand O\ntwo O\nheady O\nweeks O\nafter O\ntaking O\ncharge O\nof O\nthe O\nChechen B-MISC\ncrisis O\n, O\nhad O\npromised O\nto O\nwrap O\nup O\nthe O\n20-month O\nwar O\nby O\nthe O\nweekend O\n. O\n\nDespite O\na O\nmood O\nof O\ncompromise O\nin O\nthe O\nregion O\nafter O\nsome O\nof O\nthe O\nworst O\nfighting O\nof O\nthe O\nwar O\n, O\nLebed B-PER\nmay O\nbe O\njust O\nfinding O\nout O\nthat O\nconcluding O\na O\nlong-term O\nsettlement O\n, O\nsomewhere O\nbetween O\nrebel O\ndemands O\nfor O\nindependence O\nand O\nMoscow B-LOC\n's O\ninsistence O\nthat O\nChechnya B-LOC\nremain O\npart O\nof O\nRussia B-LOC\n, O\nwill O\nbe O\nno O\neasy O\nmatter O\n. O\n\nA O\nchain-smoking O\nformer O\nparatroop O\ngeneral O\nwith O\na O\nsharp O\nline O\nin O\ndeadpan O\nputdowns O\nand O\na O\nsoldier O\n's O\nknack O\nfor O\nmaking O\nlife O\nsound O\nsimple O\n, O\nLebed B-PER\nmanaged O\nto O\narrange O\nan O\nambitious O\nceasefire O\nin O\nthe O\nregion O\nlast O\nweek O\n, O\ndays O\nafter O\nthe O\nRussian B-MISC\narmy O\nthreatened O\nto O\nbomb O\nits O\nway O\nback O\ninto O\nthe O\nrebel-held O\nChechen B-MISC\ncapital O\nGrozny B-LOC\n. O\n\nHe O\nreturned O\nat O\nthe O\nweekend O\n, O\npledging O\nto O\nconclude O\na O\npolitical O\nsettlement O\nthat O\nwould O\nmake O\nthis O\ntruce O\nwork O\nwhere O\nall O\nothers O\nhave O\nfailed O\n. O\n\nBut O\nthen O\nhe O\napparently O\nthought O\nbetter O\nof O\nit O\n. O\n\nSaying O\nhe O\nneeded O\nto O\ntidy O\nup O\nlegal O\nloose O\nends O\non O\nthe O\ndeal O\n-- O\nand O\nalso O\ncover O\nhis O\nback O\nagainst O\nunnamed O\npro-war O\nschemers O\nin O\nMoscow B-LOC\n-- O\nhe O\nflew O\nback O\nto O\nthe O\ncapital O\nempty-handed O\non O\nSunday O\n. O\n\nHe O\nmet O\nRussian B-MISC\nPrime O\nMinister O\nViktor B-PER\nChernomyrdin I-PER\non O\nMonday O\nand O\n, O\naccording O\nto O\nthe O\npress O\nservice O\nof O\nLebed B-PER\n's O\nSecurity B-ORG\nCouncil I-ORG\n, O\ncould O\nmeet O\nYeltsin B-PER\non O\nTuesday O\n. O\n\nIt O\nwas O\nnot O\nclear O\nif O\nthe O\nstart O\nof O\nYeltsin B-PER\n's O\nholiday O\n, O\nannounced O\nlater O\n, O\nwould O\naffect O\nplans O\nto O\ntalk O\n. O\n\nMoscow B-LOC\n's O\nas O\nyet O\nundisclosed O\nproposals O\non O\nChechnya B-LOC\n's O\npolitical O\nfuture O\nhave O\n, O\nmeanwhile O\n, O\nbeen O\nsent O\nback O\nto O\ndo O\nthe O\nrounds O\nof O\nvarious O\ngovernment O\ndepartments O\n. O\n\nIt O\nis O\nnot O\nknown O\nwhat O\ncaused O\nthe O\ndelay O\nin O\nthe O\npeace O\nplan O\n. O\n\nSpeculation O\nmounted O\nlast O\nweek O\nthat O\nLebed B-PER\nwas O\noperating O\nout O\non O\na O\nlimb O\nin O\nChechnya B-LOC\nas O\nYeltsin B-PER\n, O\nhardly O\nseen O\nsince O\nhis O\nreelection O\nlast O\nmonth O\n, O\nkept O\nout O\nof O\nsight O\nand O\nthen O\ngave O\nan O\ninterview O\ncriticising O\nhis O\nenvoy O\njust O\nas O\nhe O\nclinched O\na O\ntruce O\n. O\n\nBut O\nChernomyrdin B-PER\ntook O\npains O\nat O\nthe O\nweekend O\nto O\ninsist O\nLebed B-PER\nwas O\nplaying O\nfor O\na O\nunited O\nteam O\nand O\nthat O\nthe O\nproposals O\nhe O\ntook O\nto O\nrebel O\nchief-of-staff O\nAslan B-PER\nMaskhadov I-PER\nhad O\nbeen O\nagreed O\nby O\nYeltsin B-PER\n. O\n\nIf O\nthat O\nwere O\nthe O\ncase O\n, O\nit O\nwas O\nunclear O\nwhy O\nLebed B-PER\nsuddenly O\nfound O\nit O\nnecessary O\nto O\nhave O\nthe O\ndeal O\nverified O\nin O\nMoscow B-LOC\n. O\n\nLebed B-PER\nhimself O\nsaid O\nhe O\nwas O\nconcerned O\nthat O\npowerful O\ninterests O\nin O\nMoscow B-LOC\n, O\nwho O\nhave O\nprofited O\nfrom O\nthe O\nwar O\nand O\nwant O\nit O\nto O\ngo O\non O\n, O\nwould O\nseize O\non O\nany O\ninadequacy O\nin O\nthe O\ndeal O\nto O\nremove O\nhim O\n. O\n\nMaskhadov B-PER\nwarned O\nthat O\nLebed B-PER\nrisked O\nthe O\nsame O\nfate O\nas O\na O\nformer O\nRussian B-MISC\narmy O\ncommander O\nin O\nthe O\nregion O\nwho O\nsought O\na O\ncompromise O\nand O\nwas O\nblown O\nup O\nlast O\nyear O\nby O\n-- O\nso O\nthe O\nChechens B-MISC\nsay O\n-- O\nRussian B-MISC\nforces O\n. O\n\nMaskhadov B-PER\nmay O\nalso O\nhave O\nmade O\nnew O\ndemands O\non O\nLebed B-PER\n, O\nforcing O\nhim O\nto O\ncheck O\nback O\nwith O\nthe O\nKremlin B-LOC\non O\nwhat O\nhe O\ncould O\noffer O\n. O\n\nA O\nrebel O\nspokesman O\nsaid O\nthe O\ntwo O\nmilitary O\nmen O\nhad O\ncome O\nclose O\nto O\nagreement O\non O\na O\nface-saving O\nformula O\nacceptable O\nto O\nboth O\nsides O\nand O\ninvolving O\na O\nreferendum O\non O\nindependence O\nat O\nsome O\nfuture O\ndate O\n. O\n\nChernomyrdin B-PER\nsaid O\nvoters O\nshould O\ndecide O\nChechnya B-LOC\n's O\nfuture O\nbut O\nstressed O\nthere O\nwas O\nno O\nquestion O\nof O\nthe O\ngovernment O\nletting O\nthe O\nregion O\nquit O\nthe O\nRussian B-LOC\nFederation I-LOC\n-- O\nsomething O\nMoscow B-LOC\nfears O\ncould O\nencourage O\nseparatist O\ntendencies O\nin O\nother O\nethnic O\nregions O\n, O\nparticularly O\nin O\nthe O\nstrategic O\nNorth B-LOC\nCaucasus I-LOC\n. O\n\nLebed B-PER\nmay O\nbe O\nbe O\nfinding O\nthat O\nclosing O\nthat O\npolitical O\ngap O\nbetween O\nthe O\ntwo O\nsides O\nis O\nmore O\ndifficult O\nthan O\njust O\nending O\na O\nwar O\n. O\n\n-DOCSTART- O\n\nYeltsin B-PER\non O\nholiday O\nfrom O\nMonday O\n- O\nInterfax B-ORG\n. O\n\nMOSCOW B-LOC\n1996-08-26 O\n\nRussian B-MISC\nPresident O\nBoris B-PER\nYeltsin I-PER\nbegan O\na O\nnew O\nsummer O\nholiday O\non O\nMonday O\nbut O\nwould O\nremain O\nin O\ncontrol O\nof O\naffairs O\nof O\nstate O\n, O\nInterfax B-ORG\nnews O\nagency O\nsaid O\n. O\n\n\" O\nThe O\nhead O\nof O\nstate O\n's O\nholiday O\nhas O\nonly O\njust O\nbegun O\n, O\n\" O\nthe O\nagency O\nquoted O\nSergei B-PER\nYastrzhembsky I-PER\nas O\nsaying O\n, O\nadding O\nthat O\nthe O\npresident O\nwas O\ncurrently O\nin O\na O\nKremlin B-LOC\nresidence O\nnear O\nMoscow B-LOC\n. O\n\nInterfax B-ORG\nsaid O\nYastrezhembsky B-PER\ndid O\nnot O\nexclude O\nthat O\nYeltsin B-PER\ncould O\nspend O\nsome O\ntime O\nin O\nother O\nplaces O\n. O\n\nHe O\nwould O\ncontinue O\nworking O\non O\nvarious O\ndocuments O\nand O\nmight O\nmeet O\n\" O\none O\nstate O\noffical O\nor O\nanother O\n\" O\n. O\n\n\" O\nOne O\nmust O\ngive O\nB. B-PER\nYeltsin I-PER\na O\nchance O\nto O\nrest O\nand O\nrecover O\nhis O\nhealth O\nafter O\nthe O\nelections O\n, O\n\" O\nInterfax B-ORG\nquoted O\nYastrezhembsky B-PER\nas O\nsaying O\n. O\n\n\" O\n( O\nYeltsin B-PER\n) O\ncontrols O\ninternal O\nand O\ninternational O\npolicies O\n, O\ndaily O\nreceives O\na O\nbig O\npacket O\nof O\ndocuments O\nfrom O\nMoscow B-LOC\n, O\nwhich O\ndemand O\nhis O\nintervention O\n... O\n\nMany O\nof O\nthose O\ndocuments O\nreturn O\nto O\nthe O\npresident O\n's O\nadministration O\nthe O\nsame O\nday O\n, O\n\" O\nhe O\nsaid O\n. O\n\nYeltsin B-PER\nwent O\non O\na O\ntwo-day O\ntrip O\noutside O\nMoscow B-LOC\nlast O\nweek O\nto O\ncheck O\nout O\na O\nholiday O\nhome O\n. O\n\n-DOCSTART- O\n\nYugo B-ORG\nZastava I-ORG\nworkers O\n' O\nprotest O\nenters O\n2nd O\nweek O\n. O\n\nBELGRADE B-LOC\n1996-08-26 O\n\nThousands O\nof O\nworkers O\nof O\nSerbia B-LOC\n's O\nZastava B-ORG\narms O\nfactory O\nentered O\nthe O\nsecond O\nweek O\nof O\nprotests O\non O\nMonday O\nover O\nunpaid O\nwages O\nand O\nthe O\nlack O\nof O\na O\nprogramme O\nto O\nrevive O\nthe O\nplant O\n's O\nproduction O\n. O\n\n\" O\nWe O\nare O\nstubborn O\n, O\nhave O\nstrength O\nand O\ntime O\nto O\npersist O\nuntil O\nour O\ndemands O\nare O\nmet O\n, O\n\" O\nsaid O\nthe O\nfactory O\n's O\ntrade O\nunion O\nsecretary O\nDragutin B-PER\nStanojlovic I-PER\n. O\n\n\" O\nWe O\nare O\nunited O\nand O\nwe O\nare O\nwaiting O\nfor O\nthe O\ngovernment O\nto O\ndecide O\nwhat O\nto O\ndo O\nwith O\nus O\n. O\n\" O\n\nTrade O\nunions O\ndemanded O\npayment O\nof O\nJune O\nand O\nJuly O\nwages O\nand O\nlast O\nyear O\n's O\nholiday O\npay O\n, O\nand O\ncalled O\non O\ngovernment O\nto O\ndevelop O\na O\nrevival O\nprogramme O\nfor O\nthe O\nplant O\n. O\n\nThe O\nformer O\nYugoslav B-MISC\nnational O\narmy O\nconsumed O\n90 O\npercent O\nof O\nZastava B-ORG\n's O\npre-war O\noutput O\n, O\nbut O\nlike O\nthe O\nrest O\nof O\nYugoslavia B-LOC\n's O\neconomy O\n, O\nthe O\nnew O\narmy O\nof O\nSerbia B-LOC\nand O\nMontenegro B-LOC\nis O\ncrippled O\nby O\nlack O\nof O\nfunds O\n. O\n\nIn O\nKragujevac B-LOC\nwhere O\nthe O\nplant O\nis O\nbased O\n, O\n9,000 O\nto O\n10,000 O\npeople O\ngathered O\nin O\nthe O\ncentral O\nsquare O\nto O\nexpress O\ntheir O\nbitterness O\nat O\nwhat O\nStanojlovic B-PER\ncalled O\ngovernment O\nindifference O\n. O\n\nThe O\nruling O\nSocialist B-ORG\nParty I-ORG\nlast O\nweek O\naccused O\nSerbia B-LOC\n's O\nopposition O\nof O\nstirring O\nup O\nsocial O\nunrest O\nand O\nusing O\nworkers O\n' O\nalready O\ndifficult O\nsocial O\nposition O\nfor O\ntheir O\nown O\ninterests O\n. O\n\n\" O\nLate O\nwages O\n, O\nno O\nwork O\nand O\n( O\nthe O\nlack O\nof O\na O\n) O\nproduction O\nprogramme O\nare O\nthe O\nmain O\nreasons O\nfor O\ntheir O\nprotests O\n, O\n\" O\na O\nsenior O\nmember O\nof O\nthe O\nlocal O\nSocialist B-ORG\nParty I-ORG\nbranch O\ntold O\nReuters B-ORG\n. O\n\n\" O\nBut O\nthere O\nis O\na O\nsignificant O\ninfluence O\nof O\nopposition O\nparties O\nthat O\nare O\ncollecting O\npoints O\nahead O\nof O\ncoming O\nelections O\n. O\n\" O\n\nFederal O\nYugoslav B-MISC\nelections O\nare O\ndue O\non O\nNovember O\n3 O\n. O\n\nThe O\nparty O\nofficial O\nsaid O\nthe O\nunion O\n's O\nfigure O\non O\nthe O\nnumber O\nof O\nprotesters O\nwas O\nexaggerated O\n. O\n\" O\n\nThere O\nwere O\nabout O\n1,400 O\nto O\n1,600 O\npeople O\nat O\nthe O\nprotest O\ntoday O\n-- O\nmuch O\nless O\nthen O\nlast O\nweek O\n. O\n\n\" O\nBut O\nthere O\nwere O\nmore O\nobservers O\nand O\npassers O\nby O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-- O\nGordana B-PER\nKukic I-PER\n, O\nBelgrade B-ORG\nNewsroom I-ORG\n+381 O\n11 O\n222 O\n4254 O\n\n-DOCSTART- O\n\nCroatian B-MISC\nlending O\nrate O\nfalls O\nto O\n8.0 O\nvs O\n9.1 O\npct O\n. O\n\nZAGREB B-LOC\n1996-08-26 O\n\nThe O\nCroatian B-MISC\nlending O\nrate O\nfell O\nto O\n8.0 O\npercent O\non O\nMonday O\nfrom O\nlast O\nFriday O\n's O\n9.1 O\npercent O\nafter O\nthin O\ndemand O\nfor O\nkuna O\nforced O\nbank O\nlenders O\nto O\ntrim O\ntheir O\nrates O\nfurther O\n. O\n\nInterbank B-ORG\ncall O\nmoney O\nwas O\ndown O\nto O\n8.0 O\nfrom O\n10.0 O\npercent O\n. O\n\nInsurers O\n' O\nfive-10 O\nand O\n10-15 O\nday O\nloans O\nwere O\nmade O\nat O\na O\nsteady O\n8.0 O\npercent O\nafter O\nlast O\nweek O\n's O\ndrop O\nfrom O\nan O\nearlier O\n15 O\npercent O\n. O\n\nTotal O\nZagreb B-ORG\nMoney I-ORG\nMarket I-ORG\nsettlements O\nshrank O\nto O\n17.4 O\nmillion O\nkuna O\n, O\nof O\nwhich O\ndealers O\nput O\nnew O\nborrowing O\nat O\na O\nmeagre O\n5.5 O\nmillion O\n. O\n\nSupply O\nstood O\nat O\na O\nhigh O\n180 O\nmillion O\nkuna O\n. O\n\nOvernight O\ntrade O\nat O\nthe O\nweekend O\nleft O\na O\nsurplus O\nof O\n1.2 O\nbillion O\nkuna O\non O\nthe O\nsupply O\nside O\nafter O\n40 O\nmillion O\nwere O\nsettled O\n. O\n\nCroatia B-LOC\n's O\ncentral O\nbank O\nagain O\nstayed O\nout O\nof O\nthe O\nforeign O\nexchange O\nmarket O\n. O\n\nIt O\ncalculated O\nthe O\nkuna O\nmidrates O\nfor O\nTuesday O\n's O\ntrade O\nstronger O\nat O\n5.2420 O\nagainst O\nthe O\ndollar O\nand O\nslightly O\nweaker O\nat O\n3.5486 O\nagainst O\nthe O\nGerman B-MISC\nmark O\n. O\n\n-- O\nKolumbina B-PER\nBencevic I-PER\n, O\nZagreb B-ORG\nNewsroom I-ORG\n, O\n385-1-4557075 O\n\n-DOCSTART- O\n\nSVCD B-ORG\nBulgaria I-ORG\nair O\ntraffic O\ncontrollers O\nto O\nstrike O\nSeptember O\n3 O\n. O\n\nSOFIA B-LOC\n1996-08-26 O\n\nBulgarian B-MISC\nair O\ntraffic O\ncontrollers O\nwill O\ngo O\non O\nstrike O\non O\nSeptember O\n3 O\ndemanding O\nhigher O\npay O\n, O\nthe O\nchief O\nof O\nthe O\nBulgarian B-MISC\nassociation O\nof O\nair O\ntraffic O\ncontrollers O\n( O\nBulatka B-ORG\n) O\nsaid O\non O\nMonday O\n. O\n\nStefan B-PER\nRaichev I-PER\ntold O\na O\nnews O\nconference O\nthe O\nstrike O\nby O\nmore O\nthan O\nhalf O\nof O\nthe O\n1,380 O\ntraffic O\ncontrollers O\nand O\ntechnicians O\nwould O\nparalyse O\ntraffic O\nwhich O\nhas O\nincreased O\nby O\n10 O\npercent O\nsince O\nlast O\nyear O\n. O\n\nMore O\nthan O\n1,500 O\nplanes O\nper O\nday O\nfly O\nover O\nBulgaria B-LOC\n, O\nin O\na O\nstrategic O\nlocation O\nbetween O\nEurope B-LOC\nand O\nthe O\nMiddle B-LOC\nand O\nthe O\nFar B-LOC\nEast I-LOC\n, O\nRaichev B-PER\nsaid O\n. O\n\nThe O\ndirector O\ngeneral O\nof O\nthe O\nair O\ntraffic O\nservice O\nValentin B-PER\nValkov I-PER\nsaid O\nlast O\nFriday O\nthat O\na O\ncontrollers O\n' O\nstrike O\nwould O\nbe O\nillegal O\n. O\n\nValkov B-PER\nsaid O\nhe O\ncould O\nnot O\ncurb O\nthe O\nsummer O\ncharter O\nflights O\nof O\nnational O\ncarrier O\nBalkan B-ORG\nAirlines I-ORG\n, O\nwhich O\ncarries O\nthousands O\nof O\nforeign O\ntourists O\nto O\nthe O\nBulgarian B-MISC\nBlack B-LOC\nSea I-LOC\nresorts O\n. O\n\nBut O\nRaichev B-PER\nsaid O\nit O\nwould O\nbe O\n\" O\ndiscrimination O\n\" O\nagainst O\nthe O\nother O\nairlines O\nif O\nonly O\nBalkan B-LOC\nplanes O\nwere O\nguided O\nin O\n. O\n\n\" O\nUnder O\nthe O\nlaw O\nbefore O\nlaunching O\nthe O\nstrike O\nwe O\nhave O\nto O\nsign O\nan O\nagreement O\nwith O\nour O\nemployer O\nfor O\na O\nminimal O\ntransport O\nservicing O\nof O\nemergency O\nflights O\n, O\n\" O\nRaichev B-PER\nsaid O\n. O\n\nRaichev B-PER\nsaid O\na O\nlock-out O\nwith O\nmilitary O\nair O\ncontrollers O\nwas O\nimpossible O\nas O\nthey O\ndid O\nnot O\nspeak O\nEnglish B-MISC\n. O\n\nThe O\ncontrollers O\nare O\ndemanding O\nthe O\nmonthly O\nwage O\nbe O\nincreased O\nto O\n$ O\n1,000 O\nper O\nmonth O\nfrom O\nthe O\ncurrent O\n$ O\n230 O\n, O\nas O\nwell O\nas O\nthe O\nresignation O\nof O\nthe O\nair O\ntraffic O\nservice O\n's O\nmanagement O\n. O\n\nThey O\nalso O\ndemand O\nthe O\nfinancial O\nseparation O\nof O\nthe O\n350 O\nair O\ncontrollers O\nfrom O\nthe O\ntechnical O\nstaff O\n. O\n\n-- O\nLiliana B-PER\nSemerdjieva I-PER\n, O\nSofia B-ORG\nNewsroom I-ORG\n, O\n359-2-84561 O\n\n-DOCSTART- O\n\nYeltsin B-PER\n's O\nwife O\nhas O\nkidney O\noperation O\n. O\n\nMOSCOW B-LOC\n1996-08-26 O\n\nNaina B-PER\nYeltsin I-PER\n, O\nwife O\nof O\nthe O\nRussian B-MISC\npresident O\n, O\nhas O\nundergone O\n\" O\na O\nplanned O\noperation O\n\" O\non O\nher O\nleft O\nkidney O\nand O\nis O\nin O\na O\nsatisfactory O\ncondition O\n, O\nItar-Tass B-ORG\nnews O\nagency O\nsaid O\non O\nMonday O\n. O\n\nTass B-ORG\nquoted O\nthe O\nKremlin B-LOC\npress O\nservice O\nas O\nsaying O\nthe O\noperation O\ntook O\nplace O\non O\nSaturday O\nin O\nthe O\nCentral B-LOC\nClinical I-LOC\nHospital I-LOC\nwhich O\ntreats O\ntop O\nofficials O\n. O\n\nMrs O\nYeltsin B-PER\nwould O\nbe O\nreleased O\nfrom O\nhospital O\nin O\na O\nfew O\ndays O\n. O\n\nDoctor O\nSergei B-PER\nMironov I-PER\ntold O\nTass B-ORG\nNaina B-PER\nwas O\n\" O\nin O\npermanent O\ncontact O\n\" O\nwith O\nher O\nhusband O\nand O\ntwo O\ndaughters O\n, O\nYelena B-PER\nand O\nTatyana B-PER\n. O\n\nThe O\nstate O\nof O\nhealth O\nof O\nBoris B-PER\nYeltsin I-PER\n, O\nwho O\nhad O\ntwo O\nheart O\nattacks O\nlast O\nyear O\n, O\nhas O\nbeen O\nthe O\ncentre O\nof O\nmedia O\nand O\nmarket O\nspeculation O\nafter O\nhe O\nwon O\na O\nsecond O\nterm O\nin O\noffice O\nin O\nthe O\nJuly O\n3 O\nelection O\nrun-off O\nand O\nall O\nbut O\ndisappeared O\nfrom O\nthe O\npublic O\neye O\n. O\n\nA O\npresidential O\nspokesman O\nsaid O\non O\nMonday O\nYeltsin B-PER\nwas O\nin O\nMoscow B-LOC\nbut O\ncould O\ngive O\nno O\ndetails O\nabout O\nhis O\nagenda O\nor O\nwhether O\nmeetings O\nwere O\nplanned O\n. O\n\nYeltsin B-PER\nis O\nexpected O\nto O\ngo O\non O\nholiday O\nin O\nthe O\nnear O\nfuture O\n, O\nbut O\nofficials O\nhave O\nnot O\nyet O\nsaid O\nwhere O\nhe O\nwill O\ngo O\nor O\nwhen O\n. O\n\n-DOCSTART- O\n\nMostostal B-ORG\nZ I-ORG\nshareholders O\napprove O\nbonds O\n. O\n\nWARSAW B-LOC\n1996-08-26 O\n\nShareholders O\nof O\nthe O\nPolish B-MISC\nconstruction O\nfirm O\nMostostal B-ORG\nZabrze I-ORG\nHolding I-ORG\nSA I-ORG\napproved O\na O\n25- O\nmillion-zloty O\n, O\nfive-year O\nconvertible O\nissue O\nwith O\na O\npar O\nvalue O\nof O\n100 O\nzlotys O\neach O\n, O\nthe O\ncompany O\n's O\nspokesman O\nsaid O\non O\nMonday O\n. O\n\nPiotr B-PER\nGrabowski I-PER\ntold O\nReuters B-ORG\nthat O\na O\nMostostal B-ORG\nextraordinary O\nshareholders O\nmeeting O\non O\nSaturday O\nhad O\ndecided O\nthat O\nthe O\nprice O\nof O\nthe O\n250,000 O\nbonds O\nwould O\nbe O\nset O\nas O\na O\n10-session O\naverage O\nprice O\nof O\nMostostal B-ORG\nshares O\nplus O\na O\npremium O\n. O\n\n\" O\nThe O\npremium O\nwill O\nbe O\nno O\nlower O\nthan O\n15 O\npercent O\nand O\nwill O\nbe O\nset O\nby O\nmanagement O\nbefore O\nthe O\nissue O\n... O\n\nwhich O\nwe O\nexpect O\nat O\nthe O\nbeginning O\nof O\nnext O\nyear O\n, O\n\" O\nGrabowksi B-PER\nsaid O\n. O\n\nMostostal B-ORG\n, O\nbased O\nin O\nsouthern O\nPoland B-LOC\n, O\nwants O\nto O\noffer O\nthe O\nbonds O\nto O\nlarge O\ninvestors O\nin O\na O\npublic O\noffering O\n, O\npaying O\nan O\nannual O\ncoupon O\nof O\nno O\nmore O\nthan O\n80 O\npercent O\nof O\nthe O\nyield O\nof O\nthe O\nbenchmark O\n52-week O\nT-bill O\n. O\n\nThe O\nfirm O\nhas O\nsigned O\nan O\nagreement O\nwith O\nthe O\nPolish B-ORG\nDevelopment I-ORG\nBank I-ORG\n( O\nPBR B-ORG\n) O\nto O\nmanage O\nthe O\nissue O\nand O\nplans O\nthem O\nto O\nbe O\nlisted O\non O\nthe O\nWarsaw B-LOC\nbourse O\n's O\nbond O\nmarket O\n. O\n\nGrabowski B-PER\nalso O\nsaid O\nshareholders O\napproved O\nthe O\nissue O\nof O\n1.6 O\nmillion O\nshares O\nfor O\nwhich O\nthe O\nbonds O\ncould O\nbe O\nexchanged O\n, O\na O\nratio O\nof O\n6.4 O\nshares O\nper O\nbond O\n. O\n\nHe O\nalso O\nsaid O\nshareholders O\napproved O\nthe O\nissue O\nof O\n2.6 O\nmillion O\nnew O\nshares O\n, O\ntwo O\nmillion O\nof O\nwhich O\nare O\nearmarked O\nfor O\nlarge O\ninvestors O\nand O\n600,000 O\nfor O\nretail O\ndomestic O\ninvestors O\n. O\n\nThe O\nprice O\nwill O\nbe O\ndetermined O\nthrough O\nbook-building O\n. O\n\nMostostal B-ORG\nplans O\nto O\nuse O\nthe O\nproceeds O\nfrom O\nthe O\nissues O\nto O\nadd O\ncompanies O\nto O\nits O\nholding O\nand O\nmodernise O\nits O\nplant O\n. O\n\n-- O\nWarsaw B-ORG\nNewsroom I-ORG\n+48 O\n22 O\n653 O\n9700 O\n\n-DOCSTART- O\n\nUnknown O\ngroup O\nkidnaps O\nDutch B-MISC\ncouple O\nin O\nCosta B-LOC\nRica I-LOC\n. O\n\nSAN B-LOC\nJOSE I-LOC\n, O\nCosta B-LOC\nRica I-LOC\n1996-08-26 O\n\nKidnappers O\nhave O\nseized O\na O\nDutch B-MISC\ncouple O\nwho O\nmanage O\na O\nfarm O\nin O\nnorthern O\nCosta B-LOC\nRica I-LOC\nand O\nhave O\ndemanded O\na O\n$ O\n1.5 O\nmillion O\nransom O\n, O\nauthorities O\nsaid O\non O\nMonday O\n. O\n\nOfficials O\nsaid O\nHumberto B-PER\nHueite I-PER\nZyrecha I-PER\nand O\nhis O\nwife O\nJetty B-PER\nKors I-PER\n, O\nboth O\n50 O\n, O\nwere O\nkidnapped O\nlate O\non O\nSaturday O\nor O\nearly O\nSunday O\n. O\n\nCol B-LOC\n. O\n\nMisael B-PER\nValerio I-PER\n, O\nhead O\nof O\nborder O\npolice O\nat O\nthe O\nSecurity B-ORG\nMinistry I-ORG\n, O\ntold O\nreporters O\nsurveillance O\nof O\nthe O\nnorthern O\nborder O\nwith O\nNicaragua B-LOC\nhas O\nbeen O\nstepped O\nup O\nto O\nkeep O\nthe O\nkidnappers O\nfrom O\nfleeing O\nCosta B-LOC\nRica I-LOC\n. O\n\nPreliminary O\nreports O\nsaid O\nthe O\ncouple O\nwere O\nkidnapped O\non O\nthe O\n\" O\nAltamira B-LOC\n\" O\nfarm O\n, O\nowned O\nby O\nDutchman B-MISC\nRichard B-PER\nWisinga I-PER\n, O\nat O\nAguas B-LOC\nZarcas I-LOC\nde I-LOC\nSan I-LOC\nCarlos I-LOC\nnear O\nthe O\nCosta B-LOC\nRica-Nicaragua I-LOC\nborder O\n. O\n\nUnconfirmed O\nnews O\nreports O\nsaid O\na O\nvehicle O\nbelonging O\nto O\nthem O\nwas O\nfound O\nabandoned O\nat O\nSanta B-LOC\nMaria I-LOC\nde I-LOC\nPocosol I-LOC\n, O\nabout O\n12 O\nmiles O\n( O\n20 O\nkm O\n) O\nnorth O\nof O\nthe O\nsite O\nof O\nthe O\nabduction O\n. O\n\nThe O\nreports O\nsaid O\nauthorities O\nfound O\na O\nstatement O\n, O\nsupposedly O\nfrom O\nthe O\nkidnappers O\n, O\nin O\nthe O\nvehicle O\n, O\naddressed O\nto O\nWisinga B-PER\nand O\ndemanding O\na O\n$ O\n1.5 O\nmillion O\nransom O\n. O\n\nWisinga B-PER\nwas O\nbelieved O\nto O\nbe O\ntravelling O\nin O\nEurope B-LOC\n, O\nthey O\nsaid O\n. O\n\nA O\nSwiss B-MISC\ntourist O\nguide O\nand O\na O\nGerman B-MISC\ntourist O\nwere O\nkidnapped O\nin O\nthe O\nsame O\narea O\non O\nNew B-MISC\nYear I-MISC\n's I-MISC\nDay I-MISC\nby O\na O\ngroup O\nof O\nformer O\nNicaraguan B-MISC\nguerrillas O\n. O\n\nRegula B-PER\nSusana I-PER\nSiegfried I-PER\n, O\n50 O\n, O\nand O\nNicola B-MISC\nFleuchaus B-PER\n, O\n25 O\n, O\nwere O\nreleased O\nafter O\n71 O\ndays O\nafter O\na O\n$ O\n200,000 O\nransom O\nwas O\npaid O\n. O\n\nIn O\na O\nbizarre O\ntwist O\n, O\nFleuchaus B-PER\nand O\nthe O\nleader O\nof O\nthe O\nkidnappers O\n, O\nJulio B-PER\nCesar I-PER\nVega I-PER\nRojas I-PER\n, O\ndeveloped O\na O\nsentimental O\nattachment O\nduring O\nher O\ncaptivity O\n, O\naccording O\nto O\nphotographs O\nprinted O\nin O\nCosta B-MISC\nRican I-MISC\nnewspapers O\nand O\ncourt O\ndocuments O\nincluding O\na O\nlove O\nletter O\nwritten O\nby O\nVega B-PER\n. O\n\n-DOCSTART- O\n\nInteracciones B-ORG\nups O\nMexico B-LOC\nGDP O\nforecast O\n, O\nlowers O\npeso O\n. O\n\nMEXICO B-LOC\nCITY I-LOC\n1996-08-26 O\n\nInteracciones B-ORG\nbrokerage O\non O\nMonday O\nraised O\nits O\nforecasts O\nfor O\n1996 O\ngross O\ndomestic O\nproduct O\ngrowth O\nto O\n4.3 O\npercent O\nfrom O\n3.8 O\npercent O\n, O\nbut O\nit O\nkept O\nits O\n1997 O\nprojection O\nunchanged O\nat O\n4.5 O\npercent O\n, O\na O\nstatement O\nsaid O\n. O\n\nEconomist O\nAlonso B-PER\nCervera I-PER\nsaid O\nthe O\nrevisions O\nwere O\nchiefly O\nfueled O\nby O\nstronger O\nthan O\nexpected O\ngrowth O\nof O\n7.2 O\npercent O\nin O\nthe O\nsecond O\nquarter O\nand O\nhe O\nforecast O\nan O\nannual O\nGDP O\nrise O\nof O\n6.1 O\npercent O\nin O\nthe O\nthird O\nquarter O\nand O\n4.9 O\npercent O\nin O\nQ4 O\n. O\n\nThe O\nfirm O\nalso O\nrevised O\ndown O\nits O\nyear-end O\npeso O\nforecast O\nto O\n7.85-8.15 O\nper O\ndollar O\nfrom O\n8.20-8.50 O\n. O\n\nIt O\nforecast O\nan O\nend O\n1997 O\npeso O\nin O\nthe O\nrange O\nof O\n9.20-9.40 O\n. O\n\nInteracciones B-ORG\nkept O\nits O\n1996 O\nand O\n1997 O\ninflation O\nforecast O\nunchanged O\nat O\n26 O\npercent O\nand O\n20 O\npercent O\n, O\nexpecting O\nthe O\ngovernment O\n's O\n1997 O\ninflation O\ntarget O\nto O\nbe O\naround O\n15 O\npercent O\n. O\n\nIt O\nbumped O\nup O\nits O\naverage O\ninterest O\nrate O\nprojection O\nin O\n1997 O\nto O\n25.8 O\npercent O\nfrom O\n23 O\npercent O\n. O\n\nFiscal O\npolicy O\nwas O\nexpected O\nto O\nbe O\nloosened O\na O\nbit O\nin O\nthe O\nsecond O\nhalf O\nof O\nthis O\nyear O\n, O\nboosting O\ngrowth O\nwithout O\nrunning O\ninto O\na O\ndeficit O\n. O\n\n\" O\nNext O\nyear O\n, O\nthe O\nfiscal O\npolicy O\nwill O\nhave O\nless O\nmargin O\nof O\nfreedom O\nbecause O\nthe O\ngovernment O\nwill O\nhave O\nto O\nface O\ncommitments O\nthat O\nit O\nhas O\ntaken O\non O\nunder O\ndifferent O\nsupport O\nschemes O\nfor O\nthe O\nbanks O\n, O\ndebtors O\nand O\nfirms O\n, O\n\" O\nthe O\nbrokerage O\nsaid O\n. O\n\n-- O\nHenry B-PER\nTricks I-PER\n, O\nMexico B-LOC\nCity I-LOC\nnewsroom O\n+525 O\n728-9560 O\n\n-DOCSTART- O\n\nBancomext B-ORG\nofficial O\nsays O\nMexico B-LOC\npeso O\nlevel O\nsuitable O\n. O\n\nMEXICO B-LOC\nCITY I-LOC\n1996-08-26 O\n\nA O\ntop O\nofficial O\nof O\nexport O\ndevelopment O\nbank O\nBancomext B-ORG\nsaid O\nthe O\npeso O\n's O\nappreciation O\nagainst O\nthe O\ndollar O\nthis O\nyear O\nhas O\nnot O\nhurt O\ndemand O\nfor O\nMexican B-MISC\nexports O\n. O\n\n\" O\nWe O\nhave O\na O\nsuitable O\nexchange O\nrate O\n. O\n\nWe O\nhave O\nn't O\nfelt O\na O\ndrop-off O\nin O\ndemand O\n.... O\n\nWe O\nhave O\nno O\nbasis O\nfor O\nsaying O\nthat O\nthe O\nexchange O\nrate O\nis O\naffecting O\nexports O\n, O\n\" O\nRafael B-PER\nMoreno I-PER\nTurrent I-PER\n, O\ndeputy O\ndirector O\ngeneral O\nfor O\nforeign O\ntrade O\npromotion O\nat O\nthe O\nbank O\n, O\nsaid O\nat O\na O\nnews O\nconference O\n. O\n\n-DOCSTART- O\n\nColombian B-MISC\npeso O\ncloses O\nlower O\n, O\nimporters O\nbuy O\ndlrs O\n. O\n\nBOGOTA B-LOC\n1996-08-26 O\n\nColombia B-LOC\n's O\npeso O\nclosed O\nlower O\nat O\n1,044 O\nafter O\ncoming O\nunder O\npressure O\nfrom O\ndollar-buying O\nby O\nimporters O\nseeking O\nto O\nmeet O\ntheir O\ncommitments O\nabroad O\n, O\ninterbank O\ndealers O\nsaid O\n. O\n\nIt O\nwas O\nthe O\nsecond O\nconsecutive O\nsession O\nthat O\nsaw O\nthe O\npeso O\n, O\nwhich O\nended O\nat O\n1,041 O\nFriday O\n, O\nclose O\nlower O\n. O\n\n\" O\nThe O\n( O\ndollar O\n's O\n) O\nrise O\nwas O\ndue O\nto O\ndemand O\nfrom O\nimporters O\nwho O\nhave O\na O\nlot O\nof O\nwire O\ntransfers O\naccumulated O\n, O\n\" O\none O\ndealer O\nsaid O\n. O\n\nContributing O\nto O\nthe O\npeso O\n's O\nweakness O\n, O\nanother O\ndealer O\nsaid O\nbanks O\nwho O\nmight O\nhave O\nsold O\ngreenbacks O\nin O\nMonday O\n's O\ntrading O\nappeared O\nto O\nshy O\naway O\nfrom O\nthe O\nmarket O\n. O\n\nThis O\n, O\naccording O\nto O\nthe O\ntrader O\n, O\nwas O\ntypical O\nof O\nmonth-end O\nposition-squaring O\n-- O\nand O\nthe O\nfact O\nthat O\na O\nstronger O\nU.S. B-LOC\ncurrency O\nhelps O\nlimit O\nsome O\nforeign O\nexchange O\nlosses O\n. O\n\nDealers O\nreported O\n355 O\ntrades O\nfor O\na O\ntotal O\nof O\n$ O\n142 O\nmillion O\nand O\nsaid O\nthe O\npeso O\nhit O\nan O\nintra-day O\nhigh O\nof O\n1,037 O\nbefore O\nheading O\nlower O\ninto O\nthe O\nclose O\n. O\n\n-- O\nJuan B-PER\nGuillermo I-PER\nLondono I-PER\n, O\nBogota B-LOC\nnewsroom O\n, O\n571 O\n610 O\n7944 O\n\n-DOCSTART- O\n\nJapan B-LOC\n's O\nHashimoto B-PER\nleaves O\nBrazil B-LOC\nfor O\nPeru B-LOC\n. O\n\nBRASILIA B-LOC\n1996-08-26 O\n\nJapanese B-MISC\nPrime O\nMinister O\nRyutaro B-PER\nHashimoto I-PER\nleft O\nBrasilia B-LOC\non O\nMonday O\nfor O\nLima B-LOC\n, O\nthe O\npenultimate O\nstop O\non O\na O\n10-day O\nLatin B-MISC\nAmerican I-MISC\ntour O\n, O\na O\nBrazilian B-MISC\nForeign B-ORG\nMinistry I-ORG\nspokeswoman O\nsaid O\n. O\n\nHashimoto B-PER\n, O\nwho O\nhas O\nalready O\nvisited O\nMexico B-LOC\nand O\nChile B-LOC\n, O\nspent O\nthree O\ndays O\nin O\nBrazil B-LOC\n. O\n\nAfter O\nPeru B-LOC\n, O\nhe O\nwas O\ndue O\nto O\ngo O\nto O\nCosta B-LOC\nRica I-LOC\n. O\n\n-DOCSTART- O\n\nNicaraguan B-MISC\npresident O\nhas O\noperation O\nin O\nU.S B-LOC\n. O\n\nMANAGUA B-LOC\n, O\nNicaragua B-LOC\n1996-08-26 O\n\nNicaraguan B-MISC\nPresident O\nVioleta B-PER\nChamorro I-PER\nunderwent O\nsuccessful O\nsurgery O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\non O\nMonday O\nto O\ncorrect O\na O\ncompression O\nin O\nher O\nlower O\nspinal O\ncolumn O\n, O\nthe O\ngovernment O\nsaid O\n. O\n\nDoctors O\nat O\nJohns B-LOC\nHopkins I-LOC\nHospital I-LOC\nin O\nBaltimore B-LOC\nfound O\nan O\ninflamation O\nin O\nher O\nspinal O\ncolumn O\nthat O\n, O\nonce O\ntreated O\n, O\nwill O\nfree O\nher O\nof O\nchronic O\npain O\nin O\nher O\nback O\nand O\none O\nleg O\nthat O\nhas O\nlimited O\nher O\nmovement O\n, O\na O\ngovernment O\nstatement O\nsaid O\n. O\n\n\" O\n( O\nChamorro B-PER\n) O\nis O\nin O\ngood O\nhealth O\nand O\n, O\naccording O\nto O\nher O\ndoctors O\n, O\nwill O\nbe O\nable O\nto O\nreturn O\nto O\nNicaragua B-LOC\nnext O\nweek O\n, O\n\" O\nit O\nsaid O\n. O\n\nChamorro B-PER\n, O\n66 O\n, O\nhad O\ncomplained O\nof O\nlower O\nback O\npain O\nsince O\na O\ntrip O\nto O\nTaiwan B-LOC\nin O\nMay O\n, O\nwhen O\npain O\nforced O\nher O\nto O\ngo O\nto O\nTaipei B-LOC\nUniversity I-LOC\nHospital I-LOC\nfor O\nan O\nexamination O\n. O\n\nShe O\nsuffers O\nfrom O\nosteoporosis O\n, O\na O\ndisease O\nthat O\nweakens O\nthe O\nbones O\n, O\nand O\nhas O\nrepeatedly O\nflown O\nto O\nWashington B-LOC\nfor O\ntreatment O\n. O\n\nShe O\nis O\nscheduled O\nto O\nstep O\ndown O\nin O\nJanuary O\nafter O\na O\nterm O\nof O\nnearly O\nseven O\nyears O\n. O\n\n-DOCSTART- O\n\nEight O\ndrown O\nin O\nVenezuelan B-MISC\nboating O\naccident O\n. O\n\nMARACAIBO B-LOC\n, O\nVenezuela B-LOC\n1996-08-26 O\n\nEight O\nmembers O\nof O\na O\nfamily O\n, O\nfive O\nof O\nthem O\nchildren O\naged O\nbetween O\ntwo O\nand O\nseven O\n, O\ndrowned O\nwhen O\ntheir O\nsmall O\nboat O\nsank O\non O\nLake B-LOC\nMaracaibo I-LOC\nin O\nwestern O\nVenezuela B-LOC\nearly O\non O\nMonday O\n, O\nauthorities O\nsaid O\n. O\n\nThe O\naccident O\nhappened O\nwhen O\nthe O\nSanchez B-PER\nZarraga I-PER\nfamily O\ntook O\ntheir O\nboat O\nout O\nfor O\na O\nnighttime O\nspin O\n, O\nCivil B-ORG\nDefence I-ORG\nand I-ORG\nCoast I-ORG\nGuard I-ORG\nofficials O\nsaid O\n. O\n\nThe O\ncause O\nof O\nthe O\nsinking O\nwas O\nnot O\nknown O\nbut O\nofficials O\nsaid O\nthe O\nboat O\nhad O\na O\nhole O\nin O\nthe O\nstern O\nand O\nno O\nlifejackets O\n. O\n\nThree O\nmembers O\nof O\nthe O\nparty O\nwere O\nrescued O\nunhurt O\n. O\n\n-DOCSTART- O\n\nBanco B-ORG\nde I-ORG\nMexico I-ORG\nto O\ninject O\n3.412 O\nbln O\npesos O\n. O\n\nMEXICO B-LOC\nCITY I-LOC\n1996-08-26 O\n\nBanco B-ORG\nde I-ORG\nMexico I-ORG\nsought O\nto O\ninject O\n3.412 O\nbillion O\npesos O\nin O\nthe O\nsecondary O\nmarket O\non O\nMonday O\nthrough O\nthree O\ncredit O\nauctions O\n, O\ndealers O\nsaid O\n. O\n\nThe O\nauctions O\nwere O\noffered O\nas O\nfollows O\n: O\n\nAMOUNT O\nTERM O\n\n1.206 O\nbln O\n9 O\ndays O\n\n1.206 O\nbln O\n3 O\ndays O\n\n1.000 O\nbln O\n1 O\nday O\n\n- O\nMexico B-LOC\nCity I-LOC\nnewsroom O\n525 O\n728-9559 O\n\n-DOCSTART- O\n\nDutch B-MISC\ncouple O\nkidnapped O\nin O\nCosta B-LOC\nRica I-LOC\n. O\n\nSAN B-LOC\nJOSE I-LOC\n, O\nCosta B-LOC\nRica I-LOC\n1996-08-26 O\n\nA O\nDutch B-MISC\ncouple O\nwho O\nmanage O\na O\nfarm O\nin O\nnorthern O\nCosta B-LOC\nRica I-LOC\nhave O\nbeen O\nkidnapped O\nby O\nan O\nunidentified O\ngroup O\ndemanding O\n$ O\n1.5 O\nmillion O\nin O\nransom O\n, O\nauthorities O\nsaid O\non O\nMonday O\n. O\n\nOfficials O\nsaid O\nHumberto B-PER\nHueite I-PER\nZyrecha I-PER\nand O\nhis O\nwife O\nJetty B-PER\nKors I-PER\n, O\nboth O\n50 O\n, O\nwere O\nkidnapped O\nlate O\nSaturday O\nor O\nearly O\nSunday O\n. O\n\nCol B-LOC\n. O\n\nMisael B-PER\nValerio I-PER\n, O\nhead O\nof O\nborder O\npolice O\nat O\nthe O\nSecurity B-ORG\nMinistry I-ORG\n, O\ntold O\nreporters O\nthat O\nsurveillance O\nof O\nthe O\ncountry O\n's O\nnorthern O\nborder O\nwith O\nNicaragua B-LOC\nhas O\nbeen O\nstepped O\nup O\nto O\nstop O\nthe O\nkidnappers O\nfrom O\nfleeing O\nCosta B-LOC\nRica I-LOC\n. O\n\nNo O\nother O\ndetails O\nwere O\nimmediately O\navailable O\n. O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nMelbourne B-LOC\ntrain O\ncollides O\nwith O\ntruck O\n, O\n15 O\ninjured O\n. O\n\nMELBOURNE B-LOC\n1996-08-26 O\n\nFifteen O\npeople O\nwere O\ninjured O\nwhen O\na O\nsuburban O\npassenger O\ntrain O\nand O\na O\ntruck O\ncollided O\nat O\na O\nstreet-level O\nrail O\ncrossing O\nin O\nthe O\nAustralian B-MISC\ncity O\nof O\nMelbourne B-LOC\non O\nMonday O\n, O\nsaid O\nrail O\nand O\nambulance O\nofficials O\n. O\n\nThe O\ninjured O\n, O\nwhich O\nincluded O\na O\npregnant O\nwoman O\n, O\nwere O\ntaken O\nto O\nhospital O\n, O\nbut O\nwere O\nnot O\nin O\na O\nserious O\ncondition O\n, O\nan O\nambulance O\nspokesman O\ntold O\nReuters B-ORG\n. O\n\nA O\nPublic B-ORG\nTransport I-ORG\nCorporation I-ORG\nspokesman O\nsaid O\nthe O\ntrain O\n, O\ncollided O\nwith O\nthe O\ntruck O\nloaded O\nwith O\nconcrete O\npylons O\nin O\nthe O\nnorth O\nMelbourne B-LOC\nsuburb O\nof O\nPreston B-LOC\njust O\nbefore O\n8.30 O\na.m O\n.. O\n\nThe O\ntrain O\nwas O\nderailed O\nwhen O\na O\ncorner O\nof O\nthe O\ndriver O\n's O\ncompartment O\ncaught O\nthe O\nrear O\nof O\nthe O\ntruck O\n, O\nthe O\nspokesman O\nsaid O\n. O\n\nThe O\ntruck O\nwas O\noverturned O\n, O\nspilling O\nits O\nload O\nonto O\nthe O\ncrossing O\n, O\nand O\ncareered O\ninto O\nthe O\nnearby O\nBell B-LOC\nSt I-LOC\nStation I-LOC\n. O\n\n\" O\nRemarkably O\nboth O\nthe O\ntrain O\ndriver O\nand O\nthe O\ntruck O\ndriver O\nwere O\nnot O\ninjured O\n, O\n\" O\nthe O\nrail O\nspokesman O\nsaid O\n. O\n\n\" O\nIt O\nhad O\nthe O\npotential O\nto O\nbe O\nquite O\na O\nnasty O\naccident O\n. O\n\" O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n373-1800 O\n\n-DOCSTART- O\n\nPolice O\ncapture O\nAuckland B-LOC\ngunman O\n. O\n\nAUCKLAND B-LOC\n1996-08-27 O\n\nA O\ngunman O\nbeing O\nhunted O\non O\nAuckland B-LOC\n's O\nNorth B-LOC\nShore I-LOC\nwas O\ncaptured O\nby O\npolice O\njust O\nafter O\n9 O\na.m. O\non O\nTuesday O\n, O\nNew B-ORG\nZealand I-ORG\nPress I-ORG\nAssociation I-ORG\nreported O\n. O\n\nSenior O\nSergeant O\nDave B-PER\nPearson I-PER\nof O\nAuckland B-LOC\npolice O\nsaid O\nJohn B-PER\nGrant I-PER\nFagan I-PER\nwas O\nin O\npolice O\ncustody O\n, O\nbut O\nfurther O\ndetails O\nof O\nhis O\ncapture O\nwould O\nnot O\nbe O\nreleased O\nuntil O\na O\npress O\nconference O\nlater O\nin O\nthe O\nday O\n. O\n\nFagan B-PER\nhad O\nearlier O\ntelephoned O\nan O\nAuckland B-LOC\nradio O\nstation O\nin O\na O\ndistraught O\nstate O\n, O\nsaying O\nhe O\nfeared O\nfor O\nhis O\nlife O\n. O\n\nPolice O\nsaid O\nhe O\ndid O\nnot O\nhave O\na O\nweapon O\nwhen O\ntaken O\ninto O\ncustody O\nand O\nwas O\nnow O\ncooperating O\nwith O\nthem O\n. O\n\nRadio B-ORG\nNew I-ORG\nZealand I-ORG\nreported O\nearlier O\nthat O\nan O\narmed O\nman O\non O\nMonday O\nentered O\nthe O\nNorthcote B-ORG\nCollege I-ORG\nswimming O\npool O\nchanging O\nsheds O\nand O\nconfronted O\na O\n16-year-old O\nschoolgirl O\n. O\n\nA O\nshot O\nwas O\nfired O\n, O\nbut O\nonlookers O\nmanaged O\nto O\ndisarm O\nthe O\nman O\n. O\n\n-- O\nWellington B-LOC\nnewsroom O\n64 O\n4 O\n473-4746 O\n\n-DOCSTART- O\n\nPolice O\nseek O\nfugitive O\nafter O\nAuckland B-LOC\ngun O\nincident O\n. O\n\nWELLINGTON B-LOC\n1996-08-27 O\n\nAuckland B-LOC\npolice O\nwere O\nseeking O\nan O\nescaped O\ngunman O\non O\nTuesday O\nafter O\nan O\nincident O\nin O\nwhich O\nhe O\nfired O\nat O\na O\n16-year-old O\nschoolgirl O\n, O\nRadio B-ORG\nNew I-ORG\nZealand I-ORG\nsaid O\n. O\n\nThe O\nman O\nentered O\nthe O\nNorthcote B-ORG\nCollege I-ORG\nswimming O\npool O\nchanging O\nsheds O\non O\nMonday O\nand O\ntold O\nthe O\ngirl O\nand O\na O\nfriend O\n: O\n\" O\nYou O\n're O\nfor O\nit O\nnow O\n. O\n\" O\n\nA O\nshot O\nwas O\nfired O\n, O\nbut O\nonlookers O\nmanaged O\nto O\nseize O\nthe O\ngun O\n, O\nthe O\nradio O\nsaid O\n. O\n\nPolice O\n, O\nwho O\nwere O\nunsuccessful O\nin O\nfinding O\nthe O\nman O\novernight O\n, O\ndescribed O\nhim O\nas O\ndisturbed O\nand O\ndangerous O\n. O\n\n-- O\nWellington B-LOC\nnewsroom O\n64 O\n4 O\n473-4746 O\n\n-DOCSTART- O\n\nSIMEX B-ORG\nBrent I-ORG\nclosed O\non O\nMonday O\nowing O\nto O\nIPE B-ORG\nholiday O\n. O\n\nSINGAPORE B-LOC\n1996-08-26 O\n\nThe O\nBrent B-ORG\ncrude O\nfutures O\nmarket O\non O\nthe O\nSingapore B-ORG\nInternational I-ORG\nMonetary I-ORG\nExchange I-ORG\n( O\nSIMEX B-ORG\n) O\nwas O\nclosed O\non O\nMonday O\nin O\nrespect O\nfor O\na O\nU.K. B-LOC\nnational O\nholiday O\n. O\n\nTHE O\nSIMEX B-ORG\nBrent I-ORG\nmarket O\nkeeps O\nto O\nthe O\ntrading O\nschedule O\nof O\nthe O\nInternational B-ORG\nPetroleum I-ORG\nExchange I-ORG\n( O\nIPE B-ORG\n) O\nin O\nLondon B-LOC\n, O\nwhich O\nis O\nclosed O\nfor O\na O\nBritish B-MISC\nbank O\nholiday O\n. O\n\nContracts O\ntraded O\nin O\nSingapore B-LOC\nare O\nmutually O\noffset O\nagainst O\ncontracts O\ntraded O\nin O\nLondon B-LOC\n. O\n\n-- O\nSingapore B-ORG\nNewsroom I-ORG\n( O\n+65 O\n870 O\n3081 O\n) O\n\n-DOCSTART- O\n\nMetro B-ORG\nslides O\n3.3 O\npct O\nafter O\nmarket O\nopens O\n. O\n\nSINGAPORE B-LOC\n1996-08-26 O\n\nShares O\nin O\nretailer O\nMetro B-ORG\nHoldings I-ORG\ndropped O\n3.31 O\npercent O\n, O\nor O\nSingapore B-LOC\n$ O\n0.20 O\n, O\nto O\nS$ B-MISC\n5.85 O\nminutes O\nafter O\nthe O\nmarket O\nopened O\non O\nMonday O\n. O\n\nBy O\n0120 O\nGMT B-MISC\n, O\n357,000 O\nMetro B-ORG\nshares O\nhad O\nbeen O\ntraded O\n. O\n\nOn O\nFriday O\n, O\nMetro B-ORG\nHoldings I-ORG\ntopped O\ngainers O\n, O\nsoaring O\nby O\nS$ B-MISC\n1.55 O\nto O\nclose O\nat O\nS$ B-MISC\n6.05 O\non O\nmarket O\nrumours O\nof O\na O\ntakeover O\nbid O\nby O\nFirst B-ORG\nCapital I-ORG\nCorp I-ORG\n. O\n\nThe O\ncompany O\nsaid O\nit O\nwas O\nnot O\naware O\nof O\nany O\nreason O\nfor O\nthe O\nsurge O\n. O\n\n-- O\nSingapore B-LOC\nnewsroom O\n( O\n65 O\n8703080 O\n) O\n\n-DOCSTART- O\n\nIndonesian B-MISC\nrupiah O\nstable O\nin O\nquiet O\nlate O\ntrading O\n. O\n\nJAKARTA B-LOC\n1996-08-26 O\n\nThe O\nIndonesian B-MISC\nrupiah O\nwas O\nstable O\nagainst O\nthe O\ndollar O\nin O\nquiet O\ntrading O\non O\nMonday O\n, O\ndealers O\nsaid O\n. O\n\nThey O\nsaid O\nvolume O\nwas O\nthin O\nfollowing O\na O\npublic O\nholiday O\nin O\nHong B-LOC\nKong I-LOC\nand O\nthe O\nUnited B-LOC\nKingdom I-LOC\n. O\n\n\" O\nWe O\ndid O\nn't O\nsee O\nanything O\nfrom O\nSingapore B-LOC\noperators O\neither O\n. O\n\nIt O\n's O\na O\npretty O\nquiet O\nday O\n, O\n\" O\none O\nforeign O\nbank O\ndealer O\nsaid O\n. O\n\nSpot O\nrupiah O\nwas O\nquoted O\nat O\n2,342.0 O\n/ O\n42.5 O\nat O\n0915 O\nGMT B-MISC\n, O\nunchanged O\nfrom O\nthe O\nopening O\nlevel O\n. O\n\nIt O\nwas O\nsofter O\nin O\nthe O\nmorning O\ndue O\nto O\nrelatively O\nample O\nrupiah O\nliquidity O\nbut O\nrecovered O\nlater O\n. O\n\nTomorrow O\nand O\ntoday O\nrupiah O\nclosed O\nat O\n2,342.00 O\n/ O\n42.45 O\nand O\n2,341.5 O\n/ O\n42.0 O\n, O\nrespectively O\n. O\n\nAnother O\ndealer O\nsaid O\noperators O\nwere O\nreluctant O\nto O\nunload O\nrupiah O\ndespite O\nample O\nconditions O\ndue O\nto O\nthe O\nmonth-end O\nfactor O\n. O\n\n\" O\nThere O\nare O\ntwo O\nfactors O\nwhich O\ndetermine O\nthe O\nmarket O\nat O\npresent O\n. O\n\nThe O\nliquidity O\nat O\nmonth-end O\nand O\nthe O\nnext O\ncourt O\nhearing O\nscheduled O\nfor O\nThursday O\n, O\n\" O\nthe O\ndealer O\nsaid O\n. O\n\nMegawati B-PER\nSukarnoputri I-PER\n, O\ndeposed O\nleader O\nof O\nthe O\nIndonesian B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nPDI B-ORG\n) O\nhas O\nsued O\nthe O\ngovernment O\nfor O\nousting O\nher O\nas O\nPDI B-ORG\nleader O\n. O\n\nThe O\ncentral O\nJakarta B-LOC\ncourt O\nadjourned O\nthe O\ncase O\nlast O\nThursday O\nfor O\npossible O\nout-of-court O\nsettlement O\n. O\n\nThe O\nhearing O\nis O\ndue O\nto O\nresume O\non O\nThursday O\n. O\n\nMegawati B-PER\n's O\nlawyers O\nsaid O\nthey O\nwere O\nstill O\ndiscussing O\na O\npossible O\nout O\nof O\ncourt O\nsettlement O\nbut O\nthey O\nwas O\nnot O\noptimistic O\nan O\nagreement O\ncould O\nbe O\nreached O\n. O\n\nThe O\ndealer O\nsaid O\nthis O\nissue O\nremained O\na O\nfactor O\nbut O\nits O\nimportance O\nto O\nthe O\nmarket O\nseemed O\nto O\ndiminish O\n. O\n\nHe O\nsaid O\nliquidity O\nwould O\nbe O\nthe O\nmain O\nconcern O\nfor O\nthe O\nnext O\nfew O\ndays O\n. O\n\nOvernight O\nswap O\nwas O\nat O\n0.45 O\n/ O\n0.48 O\nand O\ntom O\n/ O\nnext O\nat O\n0.50 O\n/ O\n0.55 O\n. O\n\nOne-month O\nswap O\nwas O\nat O\n18.0 O\n/ O\n18.5 O\n, O\ntwo O\nat O\n34.0 O\n/ O\n35.0 O\n, O\nthree O\nat O\n52.75 O\n/ O\n53.50 O\nand O\nsix O\nat O\n106.5 O\n/ O\n107.0 O\npoints O\n. O\n\nThe O\ncentral O\nbank O\nkept O\nits O\nintervention O\nrate O\nat O\n2,337 O\n/ O\n2,455 O\nand O\nthe O\nconversion O\nrate O\nat O\n2,337 O\n/ O\n2,383 O\non O\nMonday O\n. O\n\n-DOCSTART- O\n\nSenate B-ORG\nintelligence O\nchairman O\nin O\nSaudi B-MISC\nbomb O\nprobe O\n. O\n\nDUBAI B-LOC\n1996-08-26 O\n\nU.S. B-ORG\nSenate I-ORG\nIntelligence I-ORG\nCommittee I-ORG\nchairman O\nArlen B-PER\nSpecter I-PER\n, O\nwho O\nhas O\nquestioned O\nwhether O\nDefence B-ORG\nSecretary O\nWilliam B-PER\nPerry I-PER\nshould O\nresign O\nover O\nthe O\nlatest O\nbombing O\nin O\nSaudi B-LOC\nArabia I-LOC\n, O\nmet O\nSaudi B-MISC\nofficials O\non O\nMonday O\nduring O\na O\nbrief O\nvisit O\nto O\nthe O\nkingdom O\n. O\n\nA O\nU.S. B-LOC\nembassy O\nspokesman O\nin O\nRiyadh B-LOC\nsaid O\nSpecter B-PER\n, O\nwho O\narrived O\nfrom O\nneighbouring O\nOman B-LOC\non O\nSunday O\nand O\nleft O\non O\nMonday O\n, O\nhad O\ntalks O\nwith O\nSaudi B-MISC\nand O\nAmerican B-MISC\nofficials O\nin O\nDhahran B-LOC\n, O\nwhere O\n19 O\nU.S. B-LOC\nairmen O\nwere O\nkilled O\nby O\na O\nfuel O\ntruck O\nbomb O\non O\nJune O\n25 O\n, O\nand O\nRiyadh B-LOC\n. O\n\nSpecter B-PER\nmet O\nCrown O\nPrince B-PER\nAbdullah I-PER\nand O\nMinister O\nof O\nDefence B-ORG\nand I-ORG\nAviation I-ORG\nPrince O\nSultan B-PER\nin O\nJeddah B-LOC\n, O\nSaudi B-MISC\nstate O\ntelevision O\nand O\nthe O\nofficial O\nSaudi B-ORG\nPress I-ORG\nAgency I-ORG\nreported O\n. O\n\nHe O\nhad O\nearlier O\nvisited O\nJapan B-LOC\n, O\nSouth B-LOC\nKorea I-LOC\nand O\nChina B-LOC\n. O\n\nSpecter B-PER\nsaid O\nafter O\nthe O\nbombing O\nthere O\nshould O\nbe O\na O\nshake-up O\nat O\nthe O\nPentagon B-ORG\nand O\nquestioned O\nwhether O\nPerry B-PER\nshould O\nresign O\n. O\n\nHe O\nsaid O\nhe O\nwas O\nnot O\nsatisfied O\nwith O\nsome O\nof O\nPerry B-PER\n's O\nanswers O\nto O\nthe O\ncommittee O\n's O\nquestions O\nin O\nclosed O\ntestimony O\nlast O\nmonth O\n. O\n\nThe O\nquestion O\nof O\nwhether O\nPerry B-PER\nshould O\nresign O\nremained O\nopen O\n, O\nthe O\nPennsylvania B-LOC\nRepublican B-MISC\nsaid O\n. O\n\nFBI B-ORG\nDirector O\nLouis B-PER\nFreeh I-PER\n, O\nwho O\nhas O\ntwice O\nvisited O\nSaudi B-LOC\nArabia I-LOC\nto O\nseek O\nimproved O\ncooperation O\nwith O\nSaudi B-MISC\ninvestigators O\n, O\ntold O\nthe O\ncommittee O\nhe O\nwas O\nnot O\nentirely O\nsatisfied O\nwith O\nSaudi B-MISC\ncooperation O\non O\nthe O\nDhahran B-LOC\nbomb O\nand O\na O\nprevious O\nbomb O\nattack O\nin O\nRiyadh B-LOC\n. O\n\n\" O\nIf O\nwe O\n're O\nto O\nstay O\nin O\nSaudi B-LOC\nArabia I-LOC\n, O\nwe O\nneed O\nto O\nhave O\ntotal O\ncooperation O\n, O\n\" O\nSpecter B-PER\nsaid O\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\nhas O\n5,000 O\nU.S. B-LOC\nair O\nforce O\nand O\nother O\nmilitary O\npersonnel O\nin O\nSaudi B-LOC\nArabia I-LOC\n. O\n\n-DOCSTART- O\n\nHijacked O\nSudanese B-MISC\nplane O\nleaves O\nCyprus B-LOC\nfor O\nBritain B-LOC\n. O\n\nLARNACA B-LOC\n, O\nCyprus B-LOC\n1996-08-27 O\n\nA O\nSudan B-ORG\nAirways I-ORG\nplane O\nwith O\n199 O\npassengers O\nand O\ncrew O\nwhich O\nwas O\nhijacked O\nto O\nCyprus B-LOC\ntook O\noff O\nfrom O\nLarnaca B-LOC\nairport O\nafter O\nrefuelling O\nand O\nheaded O\nto O\nBritain B-LOC\nearly O\non O\nTuesday O\n, O\nwitnesses O\nsaid O\n. O\n\nPolice O\nsaid O\nan O\nunknown O\nnumber O\nof O\nhijackers O\nwere O\non O\nboard O\nthe O\nAirbus B-MISC\n310 I-MISC\nwhich O\nwas O\nhijacked O\non O\nits O\nway O\nfrom O\nKhartoum B-LOC\nto O\nAmman B-LOC\nin O\nJordan B-LOC\n. O\n\nOne O\nhad O\nthreatened O\nto O\nblow O\nit O\nup O\nunless O\nit O\nwas O\nrefuelled O\nand O\nthey O\nwere O\ntaken O\nto O\nLondon B-LOC\nwhere O\nthey O\nintended O\nto O\nsurrender O\nand O\nseek O\npolitical O\nasylum O\n. O\n\n-DOCSTART- O\n\nKurds B-MISC\nclash O\nagain O\nin O\nIraq B-LOC\n, O\ndozens O\nreported O\ndead O\n. O\n\nANKARA B-LOC\n1996-08-26 O\n\nHeavy O\nfighting O\nbroke O\nout O\nbetween O\ntwo O\nrival O\nKurdish B-MISC\nfactions O\nin O\nnorthern O\nIraq B-LOC\nat O\nmidnight O\nSunday O\nand O\nat O\nleast O\n29 O\npeople O\nwere O\nkilled O\n, O\none O\nof O\nthe O\ngroups O\nsaid O\non O\nMonday O\n. O\n\nThe O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nKDP B-ORG\n) O\nsaid O\nthe O\nPatriotic B-ORG\nUnion I-ORG\nof I-ORG\nKurdistan I-ORG\n( O\nPUK B-ORG\n) O\nhad O\nbroken O\nthe O\nU.S.-brokered B-MISC\nceasefire O\nagreed O\nbetween O\nthe O\ntwo O\nparties O\nlast O\nweek O\n. O\n\nThe O\nfactions O\nreached O\na O\nceasefire O\non O\nFriday O\nafter O\na O\nweek O\nof O\nfierce O\nfighting O\nwhich O\nhad O\nput O\nan O\nend O\nto O\na O\ntruce O\nagreed O\na O\nyear O\nearlier O\n. O\n\n\" O\nThe O\nPUK B-ORG\nleadership O\nwho O\npledged O\nto O\nend O\nfighting O\nand O\ncooperate O\nwith O\nthe O\nlatest O\nU.S. B-LOC\ninitiative O\nstarted O\na O\nmajor O\nmilitary O\noffensive O\nagainst O\nKDP B-ORG\npositions O\n, O\n\" O\nthe O\nKDP B-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\nIt O\nsaid O\nheavy O\nfighting O\nstarted O\nat O\nmidnight O\nin O\nthe O\nregion O\ndividing O\nthe O\ntwo O\nwarring O\nfactions O\n, O\nwith O\nthe O\nPUK B-ORG\naiming O\nto O\nbreak O\nthrough O\nto O\nKDP B-ORG\n's O\nheadquarters O\nin O\nSalahuddin B-LOC\n. O\n\nThe O\nKDP B-ORG\nsaid O\n29 O\nPUK B-ORG\nfighters O\nwere O\nkilled O\nin O\nthe O\nattack O\n. O\n\nIt O\ndid O\nnot O\nprovide O\ndetails O\nof O\nKDP B-ORG\ncasualties O\nand O\na O\nPUK B-ORG\nspokesman O\nwas O\nnot O\nimmediately O\navailable O\nfor O\ncomment O\n. O\n\nThe O\nstatement O\nsaid O\nthe O\nPUK B-ORG\nresumed O\nits O\nattack O\non O\nMonday O\nmorning O\non O\nKDP B-ORG\npositions O\nnear O\nRawandouz B-LOC\nand O\nindiscriminately O\nshelled O\nthe O\ntown O\nof O\nDayana B-LOC\n, O\nkilling O\na O\npriest O\nand O\ninjuring O\nsome O\ncivilians O\n. O\n\nThe O\nfighting O\nhas O\nthreatened O\na O\nU.S.-led B-MISC\npeace O\nplan O\nto O\nunite O\nthe O\nmountainous O\nKurdish B-MISC\nregion O\nin O\nnorthern O\nIraq B-LOC\nagainst O\nPresident O\nSaddam B-PER\nHussein I-PER\n. O\n\nA O\nU.S.-led B-MISC\nair O\nforce O\nhas O\nprotected O\nIraqi B-MISC\nKurds I-MISC\nagainst O\nattack O\nfrom O\nBaghdad B-LOC\nsince O\nshortly O\nafter O\nthe O\nGulf B-MISC\nWar I-MISC\nin O\n1991 O\n. O\n\n-DOCSTART- O\n\nEgypt B-LOC\nto O\npress O\nBritain B-LOC\nover O\nIslamist B-MISC\nconference O\n. O\n\nCAIRO B-LOC\n1996-08-26 O\n\nEgypt B-LOC\nwill O\ntell O\nBritain B-LOC\nit O\nis O\nconcerned O\nabout O\na O\nmeeting O\nof O\nIslamists B-MISC\nto O\nbe O\nheld O\nin O\nLondon B-LOC\nsoon O\n, O\nForeign O\nMinister O\nAmr B-PER\nMoussa I-PER\nsaid O\non O\nMonday O\n. O\n\n\" O\nThere O\nis O\na O\nquestion O\nmark O\nover O\nthis O\nissue O\n. O\n\nWe O\n, O\nand O\nmany O\nother O\ncountries O\n, O\ndo O\nn't O\nunderstand O\nthis O\n( O\nBritain B-LOC\n's O\n) O\nposition O\n, O\n\" O\nMoussa B-PER\ntold O\nreporters O\n. O\n\n\" O\nEgypt B-LOC\nwill O\ncontact O\nthe O\nBritish B-MISC\ngovernment O\nto O\nfind O\nout O\nthe O\ntruth O\nof O\nthe O\nmatter O\nand O\nto O\ndiscuss O\nthe O\npossible O\nconsequences O\nof O\nsuch O\nan O\nunfortunate O\nstep O\n, O\n\" O\nhe O\nadded O\n. O\n\nEgyptian B-MISC\ngovernment O\nnewspapers O\nhave O\ncriticised O\nBritain B-LOC\nfor O\nallowing O\nIslamists B-MISC\n, O\nwhom O\nthey O\nbrand O\nas O\n\" O\nterrorists O\n\" O\n, O\nto O\nhold O\ntheir O\nconference O\n, O\nsaying O\nthe O\nmeeting O\nwill O\nbe O\na O\nchance O\nfor O\ndangerous O\nMoslem B-MISC\nmilitants O\nto O\nplot O\nagainst O\ntheir O\ncountries O\nof O\norigin O\n. O\n\nIt O\nis O\nnot O\nclear O\nwhen O\nthe O\nconference O\nwill O\nbe O\nheld O\n. O\n\nAbout O\n1,000 O\npeople O\nhave O\nbeen O\nkilled O\nin O\nEgypt B-LOC\nsince O\nIslamic B-MISC\nmilitants O\ntook O\nup O\narms O\nin O\n1992 O\nin O\nan O\nattempt O\nto O\noverthrow O\nthe O\ngovernment O\nand O\nset O\nup O\na O\nstrict O\nIslamic B-MISC\nstate O\n. O\n\nCairo B-LOC\nsays O\nseveral O\nEgyptian B-MISC\nmilitants O\non O\nthe O\nrun O\nfrom O\ndeath O\nsentences O\nor O\nconvictions O\nfor O\nviolent O\nattacks O\nat O\nhome O\nhave O\ntaken O\nshelter O\nin O\nBritain B-LOC\n. O\n\n-DOCSTART- O\n\nIsraeli B-MISC\narmy O\nransacks O\nBedouin B-MISC\nPalestinian I-MISC\ncamp O\n. O\n\nAL-MUNTAR B-LOC\n, O\nWest B-LOC\nBank I-LOC\n1996-08-26 O\n\nIsraeli B-MISC\nsecurity O\nforces O\nransacked O\na O\nBedouin B-MISC\nencampment O\nin O\nthe O\nWest B-LOC\nBank I-LOC\non O\nMonday O\nto O\nexpel O\nthem O\nfrom O\nan O\narea O\nwhich O\nPalestinians B-MISC\nsay O\nhad O\nbeen O\nearmarked O\nfor O\nJewish B-MISC\nsettlement O\nexpansion O\n, O\nresidents O\nsaid O\n. O\n\nThey O\nsaid O\nsoldiers O\nstole O\na O\ngold O\nnecklace O\nand O\nabout O\n$ O\n2,000 O\nin O\nIsraeli B-MISC\ncurrency O\nfrom O\nan O\nelderly O\nwoman O\nand O\nher O\ndaughter-in-law O\nwhile O\nrummaging O\nthrough O\ntheir O\nluggage O\nbefore O\ndestroying O\nfamily O\nshacks O\nand O\nanimal O\nbarns O\n. O\n\n\" O\nThey O\nrammed O\nour O\nshacks O\nwith O\njeeps O\nand O\ndestroyed O\nthe O\nshack O\nover O\nmy O\nbaby O\n, O\n\" O\nsaid O\n25-year-old O\nAmina B-PER\nMuhammad I-PER\n. O\n\" O\n\nHe O\nwas O\nsaved O\nonly O\nby O\na O\nmiracle O\n. O\n\" O\n\nA O\nspokesman O\nfor O\nIsrael B-LOC\n's O\ncivil O\nadministration O\nin O\nthe O\nWest B-LOC\nBank I-LOC\nsaid O\nthe O\nBedouins B-MISC\nwere O\nmoved O\nbecause O\nthey O\nwere O\nencamped O\non O\nan O\nIsraeli B-MISC\narmy O\nfiring O\nzone O\n. O\n\nThe O\nspokesman O\nPeter B-PER\nLerner I-PER\nsaid O\nhe O\nknew O\nnothing O\nabout O\nsoldiers O\nhaving O\nstolen O\nanything O\nfrom O\nthe O\nPalestinians B-MISC\n. O\n\nIsraeli B-MISC\nsecurity O\nforces O\nhave O\nbeen O\npursuing O\nBedouin B-MISC\nPalestinians I-MISC\nliving O\nin O\nthe O\ndesolate O\nwilderness O\nbetween O\nEast B-LOC\nJerusalem I-LOC\nand O\nthe O\nDead B-LOC\nSea I-LOC\n, O\nwhere O\nseveral O\nJewish B-MISC\nsettlements O\nhave O\nbeen O\nestablished O\n. O\n\nThe O\nIsraeli B-MISC\narmy O\nalso O\nuses O\nthe O\narea O\nfor O\nmilitary O\ntraining O\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nbase O\nmetals O\nand O\nscrap O\nprices O\n- O\nAugust O\n26 O\n. O\n\nU.S. B-LOC\npremiums O\nadded O\nto O\nLME B-ORG\nofficial O\ncash O\nsettlement O\nprice O\n, O\nexcept O\nfor O\ncopper O\n, O\nwhich O\nis O\nadded O\nto O\nthe O\nCOMEX B-MISC\nspot O\nmonth O\n. O\n\nPremium O\nincludes O\nprice O\nfor O\ndelivery O\nto O\nconsumer O\n's O\nworks O\n. O\n\n-- O\n\nAluminum O\n: O\nWestern B-MISC\ngrade O\n3.25-3.75 O\ncents O\n/ O\npound O\n\nRussian B-MISC\ngrade O\nA7E O\n3.25-3.75 O\ncents O\n/ O\npound O\n\nRussian B-MISC\ngrade O\nA0 O\nnominal O\n2.00-2.25 O\ncents O\n/ O\npound O\n\nZinc O\n: O\nSpecial O\nhigh O\ngrade O\nSHG O\n5.50-6.00 O\ncents O\n/ O\npound O\n\nLead O\n3.50-4.00 O\ncents O\n/ O\npound O\n\nTin O\n( O\nGrade O\nA O\n) O\n6.5-8.5 O\ncents O\n/ O\npound O\n\n( O\nlow O\nlead O\n, O\n50 O\nppm O\n) O\n9.0-10.5 O\ncents O\n/ O\npound O\n\nNickel O\n( O\nmelting O\ngrade O\n) O\n9.0-12.0 O\ncents O\n/ O\npound O\n\nCopper O\n( O\nhigh O\ngrade O\ncathode O\n) O\n2.50-3.0 O\ncents O\n/ O\npound O\n\n-- O\n\nAluminum O\nalloy O\n( O\nA380 O\ngrade O\n) O\n, O\nMidwest B-LOC\n\nand O\nEast B-LOC\ncoast I-LOC\n, O\ndelivered O\nto O\nconsumer O\n65-66 O\ncents O\n/ O\npound O\n\n-- O\n\nAluminum O\nscrap O\n, O\nMidwest B-LOC\nand O\nEast B-LOC\ncoast I-LOC\naverage O\nprice O\n, O\n\ndelivered O\nto O\nconsumer O\n\nOld O\nSheet O\nand O\nCast O\nmetal O\n42 O\nto O\n44 O\ncents O\n/ O\npound O\n\nTurnings O\n, O\nclean O\nand O\ndry O\n43 O\nto O\n44 O\ncents O\n/ O\npound O\n\nMixed O\nlow-copper O\nclips O\n48 O\nto O\n49 O\ncents O\n/ O\npound O\n\n-- O\n\nCopper O\nscrap O\n, O\nMidwest B-LOC\nand O\nEast B-LOC\ncoast I-LOC\naverage O\nprice O\n, O\n\ndelivered O\nto O\nconsumer O\n\nNo2 O\nRefined O\n75 O\nto O\n77 O\ncents O\n/ O\npound O\n\nNo1 O\nBare O\nBright O\n91 O\nto O\n92 O\ncents O\n/ O\npound O\n\nNo1 O\nBurnt O\n87 O\nto O\n90 O\ncents O\n/ O\npound O\n\n-- O\n\nLead O\nbatteries O\n, O\ndelivered O\nconsumer O\n4.5 O\nto O\n6.0 O\ncents O\n/ O\npound O\n\nU.S. B-LOC\nProducer O\nlist O\n/ O\ntransaction O\nprices O\n\n-- O\n\nAlcan B-ORG\naluminum O\n, O\nU.S. B-LOC\nMidwest I-LOC\n( O\neffective O\ndate O\n: O\nAugust O\n1 O\n, O\n1996 O\n) O\n\nP1020 O\ningot O\n75 O\ncents O\n/ O\npound O\n\nextrusion O\nbillet O\n85 O\ncents O\n/ O\npound O\n\nNoranda B-ORG\naluminum O\n, O\nU.S. B-LOC\nMidwest I-LOC\n( O\neffective O\ndate:August O\n1 O\n, O\n1996 O\n) O\n\ningot O\n75 O\ncents O\n/ O\npound O\n\nextrusion O\nbillet O\n85 O\ncents O\n/ O\npound O\n\nRSR B-ORG\npure O\nlead O\nprice O\n( O\neffective O\ndate O\n: O\nMarch O\n20 O\n, O\n1996 O\n) O\n\n52 O\ncents O\n/ O\npound O\n\nDoe B-ORG\nRun I-ORG\npure O\nlead O\nprice O\n( O\neffective O\ndate O\n: O\nAugust O\n14 O\n, O\n1996 O\n) O\n\n50 O\ncents O\n/ O\npound O\n\nASARCO B-ORG\npure O\nlead O\n( O\neffective O\ndate O\n: O\nAugust O\n1 O\n, O\n1996 O\n) O\n\npremium O\nover O\nLME B-ORG\ncash O\n7.5 O\ncents O\n/ O\npound O\n\n-- O\n( O\nNew B-LOC\nYork I-LOC\ncommodities O\ndesk O\n212 O\n859 O\n1646 O\n) O\n\n-DOCSTART- O\n\nFlorida B-LOC\nboy O\nkills O\nhimself O\nbefore O\nstarting O\nnew O\nschool O\n. O\n\nFORT B-LOC\nLAUDERDALE I-LOC\n, O\nFla. B-LOC\n1996-08-26 O\n\nA O\n12-year-old O\nFlorida B-LOC\nboy O\nhanged O\nhimself O\nin O\nhis O\nbackyard O\njust O\nhours O\nbefore O\nhe O\nwas O\ndue O\nto O\nstart O\nat O\na O\nnew O\nschool O\non O\nMonday O\n, O\npolice O\nsaid O\n. O\n\nSamuel B-PER\nGraham I-PER\n, O\nwho O\ntold O\nhis O\nfamily O\nearlier O\nthat O\nhe O\nwas O\nnervous O\nabout O\nstarting O\nat O\na O\nnew O\nschool O\nbecause O\nhe O\nfeared O\nteasing O\nabout O\nhis O\nweight O\nproblem O\n, O\nhad O\nbeen O\ndue O\nto O\nspend O\nhis O\nfirst O\nday O\nat O\nParkway B-ORG\nMiddle I-ORG\nSchool I-ORG\nMonday O\n, O\npolice O\nsaid O\n. O\n\nThe O\nboy O\nwas O\nlast O\nseen O\nalive O\nSunday O\nnight O\nwhen O\nhe O\njoined O\nhis O\ntwo O\nyounger O\nbrothers O\nand O\nfather O\nin O\na O\nbedtime O\nprayer O\n. O\n\nTwo O\nyounger O\nbrothers O\nfound O\nhim O\nhanging O\nfrom O\na O\ntree O\nearly O\nMonday O\nmorning O\n. O\n\nHis O\nfather O\ncut O\nhim O\ndown O\nand O\ntried O\nto O\nrevive O\nhim O\nbut O\nparamedics O\npronounced O\nhim O\ndead O\nwhen O\nthey O\narrived O\n. O\n\nThe O\nBroward B-ORG\nCounty I-ORG\nSheriff I-ORG\n's I-ORG\nOffice I-ORG\nfound O\na O\nstep O\nstool O\nand O\na O\nflashlight O\nunder O\nthe O\ntree O\nwhere O\nthe O\nboy O\nwas O\nhanged O\n. O\n\nThey O\nsaid O\nthere O\nwas O\nno O\nsign O\nof O\nfoul O\nplay O\nand O\nthat O\ninvestigators O\nbelieved O\nthe O\ndeath O\nwas O\na O\nsuicide O\n. O\n\n-DOCSTART- O\n\nCBOT O\nrice O\ncloses O\nhigher O\non O\ntechnical O\nbounce O\n. O\n\nCHICAGO B-LOC\n1996-08-26 O\n\nCBOT O\nrice O\nfutures O\nclosed O\nhigher O\non O\na O\ntechnical O\nbounce O\ntied O\nto O\nsigns O\nthe O\nmarket O\nwas O\noversold O\n, O\ntraders O\nsaid O\n. O\n\n\" O\nIt O\nrallied O\non O\nideas O\nthe O\nmarket O\nwas O\noversold O\n, O\n\" O\na O\ntrader O\nsaid O\n. O\n\nTraders O\nsaid O\nthe O\nU.S. B-LOC\ncash O\nmarket O\nremains O\nwell O\nabove O\nthe O\nbenchmark O\nThai B-MISC\nprice O\nwhich O\nlimited O\ngains O\n. O\n\nRice O\nfutures O\nvolume O\nwas O\nestimated O\nat O\n450 O\ncontracts O\n, O\nup O\nfrom O\n202 O\nFriday O\n. O\n\nRice O\noptions O\nvolume O\nwas O\nestimated O\nat O\n50 O\ncontracts O\n, O\ndown O\nfrom O\n56 O\nFriday O\n. O\n\nRice O\nfutures O\nclosed O\n13 O\nto O\n16 O\ncents O\nper O\ncwt O\nhigher O\n, O\nwith O\nSeptember O\nup O\n16 O\nat O\n$ O\n10.28 O\na O\ncwt O\n. O\n\nSam B-PER\nNelson I-PER\n312-408-8721 O\n\n-DOCSTART- O\n\nTalbott B-PER\nto O\nmeet O\nRussian B-MISC\n, O\nCanadian B-MISC\ncounterparts O\n. O\n\nWASHINGTON B-LOC\n1996-08-26 O\n\nDeputy O\nSecretary O\nof O\nState O\nStrobe B-PER\nTalbott I-PER\nflew O\nto O\nOttawa B-LOC\non O\nMonday O\nto O\nmeet O\nhis O\nRussian B-MISC\ncounterpart O\nand O\ndiscuss O\na O\nrange O\nof O\nbilateral O\nand O\nEuropean B-MISC\nsecurity O\nissues O\n, O\nthe O\nState B-ORG\nDepartment I-ORG\nsaid O\n. O\n\nTalbott B-PER\n, O\nthe O\nsecond-ranking O\nState B-ORG\nDepartment I-ORG\nofficial O\n, O\nwas O\nto O\nmeet O\nRussian B-MISC\nDeputy O\nForeign O\nMinister O\nGeorgy B-PER\nMamedov I-PER\nas O\npart O\nof O\na O\nregular O\npattern O\nof O\nconsultations O\n, O\nthe O\ndepartment O\nsaid O\n. O\n\n\" O\nThere O\nis O\nmuch O\nto O\ndiscuss O\non O\nthe O\nfall O\ncalendar O\n, O\n\" O\nacting O\nchief O\nspokesman O\nGlyn B-PER\nDavies I-PER\nsaid O\n. O\n\" O\n\nThere O\n's O\na O\nfairly O\nintensive O\ndiplomatic O\ncalendar O\ncoming O\nup O\nin O\nthe O\nfall O\n. O\n\" O\n\nHe O\nsaid O\nTalbott B-PER\n, O\nwho O\nwas O\nscheduled O\nto O\nreturn O\non O\nTuesday O\n, O\nwould O\nalso O\nto O\nmeet O\nhis O\nCanadian B-MISC\ncounterpart O\n, O\nGordon B-PER\nSmith I-PER\n, O\nin O\nOttawa B-LOC\nfor O\ntalks O\nthat O\nwould O\ninclude O\nthe O\nsituation O\nin O\nHaiti B-LOC\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nMidwest I-LOC\nhog O\nmarket O\nseen O\nsteady O\nTuesday O\n- O\ntrade O\n. O\n\nCHICAGO B-LOC\n1996-08-26 O\n\nMidwest B-LOC\ndirect O\ncash O\nhog O\nprices O\nTuesday O\nwere O\nseen O\nsteady O\nfollowing O\nstrong O\ndemand O\nMonday O\nthat O\nlifted O\nprices O\nas O\nmuch O\nas O\n$ O\n1.50 O\nper O\ncwt O\nin O\nsome O\nareas O\n, O\nlivestock O\ndealers O\nsaid O\n. O\n\nThe O\ndemand O\nwas O\nsparked O\nby O\nSaturday O\n's O\nactive O\nslaughter O\n, O\nwhich O\nleft O\nsome O\npackers O\nshort O\non O\nsupplies O\nto O\nget O\nMonday O\noperations O\nstarted O\n, O\nthey O\nsaid O\n. O\n\nTop O\nprices O\nin O\nIowa B-LOC\n/ O\nsouthern O\nMinnesota B-LOC\nTuesday O\nwere O\nexpected O\nto O\nrange O\nfrom O\nmostly O\n$ O\n59.50 O\nto O\n$ O\n60.00 O\n, O\nsteady O\nfollowing O\na O\n$ O\n0.50 O\n- O\n$ O\n1.50 O\njump O\nMonday O\n. O\n\nIllinois B-LOC\ntops O\nwere O\nseen O\nmatching O\nMonday O\n's O\nat O\n$ O\n59.00 O\nwith O\ntops O\nin O\nIndiana B-LOC\nat O\n$ O\n57.50 O\n. O\n\nHowever O\n, O\nUSDA B-ORG\nreported O\ntops O\nof O\n$ O\n58.00 O\nin O\nIllinois B-LOC\nand O\nin O\nIowa B-LOC\n/ O\nsouthern O\nMinnesota B-LOC\n, O\n$ O\n60.00 O\non O\nsome O\nhogs O\nMonday O\n. O\n\nAttempts O\nto O\nmove O\nprices O\nhigher O\nagain O\nTuesday O\ncould O\nbe O\noffset O\nby O\nexpected O\nincreased O\nhog O\nmarketings O\nthis O\nweek O\n, O\nsources O\nsaid O\n. O\n\nProducers O\nwere O\nexpected O\nto O\nship O\nas O\nmany O\nhogs O\nas O\nthey O\ncan O\nahead O\nof O\nthe O\nLabor B-MISC\nDay I-MISC\nholiday O\nweekend O\n, O\nthey O\nsaid O\n. O\n\nDemand O\nfor O\nhogs O\nis O\nexpected O\nto O\nbe O\nlight O\nby O\nthe O\nend O\nof O\nthe O\nweek O\n, O\nas O\nthe O\nindustry O\nprepares O\nfor O\nLabor B-MISC\nDay I-MISC\n, O\nMonday O\n, O\nSeptember O\n1 O\nwhen O\nmost O\nU.S. B-LOC\npackers O\nwill O\nbe O\nclosed O\n. O\n\n-- O\nBob B-PER\nJanis I-PER\n312-983-7347-- O\n\n-DOCSTART- O\n\nGore B-PER\npresents O\nnew O\nimage O\nof O\nlead O\nattack O\ndog O\n. O\n\nMichael B-PER\nPosner I-PER\n\nCHICAGO B-LOC\n1996-08-26 O\n\nNo O\nmore O\nmild-mannered O\nand O\nmeek O\nAl B-PER\nGore I-PER\n, O\nthe O\nvice O\npresident O\nand O\nlikely O\nheir O\napparent O\nto O\nPresident O\nBill B-PER\nClinton I-PER\n, O\nemerged O\non O\nMonday O\nas O\nthe O\nnew O\nDemocratic B-MISC\nattack O\ndog O\nleading O\na O\nfront-line O\nassault O\non O\nBob B-PER\nDole I-PER\nand O\nHouse B-ORG\nSpeaker O\nNewt B-PER\nGingrich I-PER\n. O\n\nWhile O\nClinton B-PER\ntakes O\na O\ntrain O\ntrip O\nto O\nthe O\nDemocratic B-MISC\nConvention I-MISC\nthat O\nwill O\nrenominate O\nhim O\non O\nWednesday O\nfor O\na O\nsecond O\nterm O\n, O\nGore B-PER\nis O\nthe O\nbright O\nstar O\nin O\nthe O\nconvention O\ncity O\nnow O\n. O\n\nCrowds O\nanxiously O\nwait O\nfor O\nhis O\nappearances O\n, O\nthrusting O\nout O\nhands O\nfor O\nhim O\nto O\ngrip O\nas O\nthey O\nscream O\n\" O\n12 O\nmore O\nyears O\n\" O\n-- O\na O\nwishful O\nhope O\nto O\neight O\nyears O\nof O\nGore B-PER\nafter O\na O\nClinton B-PER\nre-election O\n. O\n\nOver O\na O\n15-hour O\nspan O\nfrom O\nSunday O\nevening O\nto O\nMonday O\nmorning O\n, O\nso O\nmany O\npeople O\njammed O\nGore B-PER\nevents O\nthat O\nthe O\nfire O\nmarshal O\nstopped O\nmembers O\nof O\nCongress B-ORG\n, O\nreporters O\nand O\nothers O\nfrom O\nentering O\na O\npro-Israel B-MISC\nrally O\nand O\na O\nmeeting O\nof O\nthe O\nNew B-LOC\nYork I-LOC\ndelegation O\n. O\n\nIn O\nhis O\nappearances O\n, O\nthe O\noften O\nstiff O\nand O\nwooden O\nGore B-PER\nseemed O\ntransformed O\ninto O\na O\nnew O\nenergetic O\n, O\ngesturing O\n\" O\npol O\n\" O\nas O\nhe O\nripped O\ninto O\nRepublican B-MISC\npresidential O\nnominee O\nDole B-PER\nand O\nGingrich B-PER\n, O\nwho O\nhas O\nemerged O\nas O\nthe O\nfavorite O\nright-wing O\nfoil O\nof O\nDemocrats B-MISC\n. O\n\nGore B-PER\ntold O\na O\nroaring O\nlabor O\nrally O\nof O\nabout O\n1,000 O\nunion O\nworkers O\nthat O\nDole B-PER\nand O\nGingrich B-PER\nwere O\nthe O\nvirtual O\npersonifaction O\nof O\nevil O\n, O\nwithout O\neven O\nmentioning O\nthat O\nformer O\nHousing O\nSecretary O\nJack B-PER\nKemp I-PER\nis O\nDole B-PER\n's O\nrunning O\nmate O\n. O\n\n\" O\nWith O\nequal O\nmeasures O\nof O\nignorance O\nand O\naudacity O\nthis O\ntwo-headed O\nmonster O\nof O\nDole B-PER\nand O\nGingrich B-PER\nhas O\nbeen O\nlaunching O\nan O\nall O\nout O\nassault O\non O\ndecades O\nof O\nprogress O\nof O\nbehalf O\nof O\nworking O\nmen O\nand O\nwomen O\n, O\n\" O\nGore B-PER\nsaid O\nto O\nwhoops O\nof O\n\" O\n12 O\nmore O\nyears O\n. O\n\" O\n\n\" O\nThey O\nwant O\nto O\ndrive O\nyou O\nout O\nof O\npolitics O\nand O\nthey O\nca O\nn't O\n, O\n\" O\nhe O\nadded O\n. O\n\" O\n\nThey O\nwant O\nto O\nsilence O\nyour O\nvoices O\nin O\nelections O\n. O\n\" O\n\nAt O\na O\ndowntown O\nhotel O\nMonday O\n, O\nthe O\n48-year-old O\nGore B-PER\ngave O\nWisconsin B-LOC\ndelegates O\na O\ntaste O\nagain O\nof O\nthe O\nnew O\nGore B-PER\n. O\n\n\" O\nI O\nwant O\nyou O\nto O\nask O\nthis O\nquestion O\n. O\n\nWhat O\nwould O\nWisconsin B-LOC\nface O\nif O\nthe O\nsame O\nextremist O\ncoalition O\n, O\nthe O\nGingrich B-ORG\n/ I-ORG\nDole I-ORG\nCongress I-ORG\n, O\nalso O\ncontrolled O\nthe O\nexecutive O\nbranch O\n? O\n\" O\n\nGore B-PER\nsaid O\n. O\n\nNoting O\nthe O\nnext O\npresidential O\nterm O\nwill O\nprobably O\nsee O\ntwo O\nor O\nthree O\nSupreme B-ORG\nCourt I-ORG\njustice O\nnominations O\n, O\nhe O\nwarned O\n, O\n\" O\nTheir O\nextremist O\nagenda O\nwould O\ncome O\nout O\nof O\nthe O\nGingrich B-ORG\nCongress I-ORG\n, O\ninto O\nand O\nthrough O\nthe O\nDole B-ORG\nWhite I-ORG\nHouse I-ORG\n, O\ndown O\nthrough O\nthe O\nSupreme B-ORG\nCourt I-ORG\n. O\n\" O\n\nHe O\npainted O\na O\nscene O\nof O\nhorrors O\nhe O\nsaw O\nif O\nRepublicans B-MISC\ncontrolled O\nthe O\nWhite B-LOC\nHouse I-LOC\nand O\nthe O\nCongress B-ORG\nthey O\nhold O\nnow O\n. O\n\" O\n\nOur O\npersonal O\nand O\nreligious O\nliberties O\nwould O\nbe O\nat O\nrisk O\n. O\n\nMedicare B-MISC\nwould O\nbe O\nat O\nrisk O\nof O\nwithering O\non O\nthe O\nvine O\n. O\n\nMedicaid B-MISC\nwould O\nbe O\nat O\nrisk O\nof O\nbeing O\ntaken O\naway O\nfrom O\npoor O\nchildren O\n. O\n\nEducation O\nwould O\nbe O\nat O\nrisk O\n. O\n\nThe O\nenvironment O\nwould O\nbe O\nat O\nrisk O\nfrom O\nthe O\npolluters O\nthat O\ncontrol O\nthat O\ncoalition O\n, O\n\" O\nhe O\nsaid O\n. O\n\nHis O\nnew O\nstyle O\nmixed O\nan O\nassault O\non O\nRepublicans B-MISC\nwith O\nwhat O\nhe O\nsees O\nas O\n\" O\nproductive O\nopportunity O\n, O\na O\nvision O\nfor O\nthe O\nfuture O\nthat O\nlifts O\nup O\nworking O\nfamilies O\n, O\nthat O\nbuilds O\nWisconsin B-LOC\nstronger O\n, O\nthat O\nbuilds O\nAmerica B-LOC\nstronger O\n. O\n\nWith O\nyour O\nhelp O\nwe O\ncan O\nre-elect O\nBill B-PER\nClinton I-PER\n. O\n\" O\n\nDole B-PER\n's O\ntax O\ncut O\nplans O\nwere O\ncalled O\n\" O\ndeja-voodoo O\neconomics O\n.... O\nIt O\n's O\na O\nwarmed-over O\nplan O\nthat O\nfailed O\nand O\ndrove O\nour O\neconomy O\ninto O\na O\nditch O\n. O\n\nWe O\ngot O\nburned O\nonce O\nand O\nwe O\nwo O\nn't O\nlet O\nthat O\nhappen O\nto O\nour O\nnation O\nagain O\n. O\n\" O\n\nGore B-PER\nridiculed O\nDole B-PER\n's O\ndefense O\nof O\nthe O\ntobacco O\nindustry O\n, O\npraised O\nClinton B-PER\nfor O\n\" O\ncourage O\n\" O\nin O\nadvancing O\nregulations O\nof O\nit O\n. O\n\nTo O\nthe O\ndelegates O\nof O\nWisconsin B-LOC\n, O\na O\nleading O\ndairy O\nstate O\n, O\nGore B-PER\nhad O\nthe O\nright O\naudience O\nin O\npoking O\nfun O\nat O\nDole B-PER\n's O\ncomparison O\nto O\naddiction O\nto O\ntobacco O\nto O\nthose O\nwho O\nca O\nn't O\ntolerate O\nmilk O\n. O\n\n\" O\nSome O\npeople O\nsay O\nmilk O\nis O\nbad O\nfor O\nyou O\n, O\n\" O\nGore B-PER\nsaid O\nas O\nWisconsin B-LOC\ndelegates O\nheld O\naloft O\na O\nplastic O\ninflated O\ncow O\n. O\n\nHe O\npraised O\nClinton B-PER\nfor O\nvetoing O\nthe O\nRepublican B-MISC\nCongress B-ORG\n' O\nattempt O\nto O\nrepeal O\nparts O\nof O\nthe O\nClean B-MISC\nAir I-MISC\nAct I-MISC\n, O\nand O\ncriticized O\nRepublicans B-MISC\nfor O\n\" O\nslashing O\nmoney O\nto O\ncombat O\ndrugs O\nin O\nschools O\n. O\n\" O\n\n\" O\nThe O\nchoice O\nhas O\nnever O\nbeen O\nstarker O\n, O\nthe O\nstakes O\ntoday O\nhave O\nnever O\nbeen O\nhigher O\n, O\n\" O\nGore B-PER\nsaid O\n. O\n\" O\n\nWe O\n're O\nnot O\ngoing O\nto O\nlet O\nthem O\nget O\naway O\nwith O\nthat O\n. O\n\" O\n\n-DOCSTART- O\n\nActor O\nReeve B-PER\nhighlights O\nDemocrats B-MISC\n' O\nfirst O\nnight O\n. O\n\nCHICAGO B-LOC\n1996-08-26 O\n\nThe O\nhighlights O\nof O\nthe O\nfirst O\nday O\nof O\nthe O\nDemocratic B-MISC\nconvention O\non O\nMonday O\nwere O\nexpected O\nto O\nfeature O\na O\nmix O\nof O\nparty O\nleaders O\nand O\npeople O\nwho O\nhave O\novercome O\nadversity O\n. O\n\nAmong O\nthe O\nlatter O\nwere O\ngun O\ncontrol O\nadvocate O\nSarah B-PER\nBrady I-PER\nand O\nactor O\nChristopher B-PER\nReeve I-PER\nand O\nthe O\npoliticians O\nincluded O\nRep B-MISC\n. I-MISC\n\nRichard B-PER\nGephardt I-PER\nand O\nSen O\n. O\n\nThomas B-PER\nDaschle I-PER\n. O\n\nHere O\nare O\nthumbnail O\nprofiles O\nof O\nthe O\nconvention O\n's O\nkey O\nMonday O\nspeakers O\n. O\n\nSarah B-PER\nBrady I-PER\n-- O\nThe O\nnation O\n's O\ntoughest O\ngun O\ncontrol O\nlaw O\nis O\nnamed O\nafter O\nRonald B-PER\nReagan I-PER\n's O\npress O\nsecretary O\nJames B-PER\nBrady I-PER\nbut O\nit O\nwas O\nhis O\nwife O\nwho O\nwas O\nthe O\nmajor O\nforce O\nbehind O\nits O\npassage O\n. O\n\nAs O\nhead O\nof O\nHandgun B-ORG\nControl I-ORG\nInc. I-ORG\n, O\nSarah B-PER\nBrady I-PER\n, O\n54 O\n, O\ncampaigned O\nnonstop O\nfor O\ntough O\ngun O\ncontrol O\nin O\nthe O\nyears O\nfollowing O\nthe O\nshooting O\nof O\nher O\nhusband O\nand O\nthen O\nPresident O\nReagan B-PER\nin O\n1981 O\n. O\n\nHer O\nreward O\nwas O\nthe O\npassage O\nin O\n1993 O\nof O\nthe O\n\" O\nBrady B-MISC\nBill I-MISC\n\" O\nwhich O\nrequires O\na O\nmandatory O\nfive-day O\nwaiting O\nperiod O\nfor O\npurchase O\nof O\nhandguns O\nand O\nalso O\nmandates O\nbackground O\nchecks O\nfor O\nwould-be O\ngun O\npurchasers O\n. O\n\nReagan B-PER\nrecovered O\nfully O\nfrom O\nhis O\nwounds O\nbut O\nBrady B-PER\n, O\nwho O\nwas O\nclose O\nto O\ndeath O\nafter O\nbeing O\nshot O\nby O\nJohn B-PER\nHinckley I-PER\nJr I-PER\n. O\n\n, O\nsuffered O\nserious O\nbrain O\ndamage O\n. O\n\nSarah B-PER\nwas O\nBrady B-PER\n's O\nsecond O\nwife O\nand O\nthey O\nhave O\na O\nson O\n, O\nJames B-PER\nScott I-PER\nBrady I-PER\nJr I-PER\n. O\n\nBefore O\nthe O\nassassination O\nattempt O\n, O\nshe O\nhad O\nworked O\nfor O\nRepublican B-MISC\ncongressmen O\nand O\nfor O\nthe O\nRepublican B-ORG\nParty I-ORG\n. O\n\nChristopher B-PER\nReeve I-PER\n-- O\nReeve B-PER\nwas O\nbest O\nknown O\nfor O\nplaying O\nthe O\ncomic O\nbook O\nhero O\nSuperman B-PER\nin O\nfour O\nmovies O\nbut O\nhis O\ngreatest O\nheroics O\ncame O\nin O\nreal O\nlife O\n. O\n\nReeve B-PER\n, O\nan O\naccomplished O\nrider O\nwho O\nowned O\nseveral O\nhorses O\n, O\nsuffered O\nmultiple O\ninjuries O\nincluding O\ntwo O\nshattered O\nneck O\nvertebrae O\nwhen O\nhe O\nwas O\nthrown O\nfrom O\nhis O\nhorse O\nat O\nan O\nequestrian O\nevent O\nin O\nCulpepper B-LOC\n, O\nVirginia B-LOC\n, O\non O\nMay O\n27 O\n, O\n1995 O\n. O\n\nAlmost O\nentirely O\nparalyzed O\n, O\nReeve B-PER\nunderwent O\nextensive O\nsurgery O\nto O\nfuse O\nthe O\nvertebrae O\nto O\nthe O\nbase O\nof O\nthe O\nskull O\nand O\nprevent O\nany O\nfurther O\ndamage O\nto O\nhis O\nspine O\n. O\n\nThat O\nallowed O\nhim O\nto O\nbe O\nmoved O\nto O\na O\nsemi-upright O\nposition O\n. O\n\nOver O\ntime O\nhe O\nregained O\nthe O\npower O\nof O\nspeech O\n, O\nso O\nmuch O\nso O\nthat O\nhe O\nwas O\nasked O\nto O\naddress O\nthe O\nopening O\nnight O\nof O\nthe O\nDemocratic B-MISC\nNational I-MISC\nConvention I-MISC\n. O\n\nReeve B-PER\n, O\n43 O\n, O\nwas O\nclassically O\ntrained O\nas O\nan O\nactor O\nbut O\nbecame O\nthe O\nprototypical O\nhandsome O\nleading O\nman O\n. O\n\nHe O\nperformed O\nin O\nsummer O\nstock O\nand O\nsoap O\noperas O\nbefore O\nbeing O\nplucked O\nas O\nan O\nalmost O\nunknown O\nto O\nplay O\nthe O\nlead O\nin O\n\" O\nSuperman B-PER\n\" O\nand O\nthree O\nsequels O\n. O\n\nRichard B-PER\nGephardt I-PER\n-- O\nGephardt B-PER\n, O\nHouse B-ORG\nDemocratic B-MISC\nleader O\n, O\nis O\na O\npolitician O\nwith O\na O\n\" O\nMr B-PER\nClean I-PER\n\" O\nreputation O\nwho O\nsought O\nthe O\npresidency O\neight O\nyears O\nago O\nand O\nis O\nwidely O\nbelieved O\nto O\nstill O\nhave O\nambitions O\nfor O\nthe O\njob O\n. O\n\nGephardt B-PER\n, O\n55 O\n, O\nthe O\nson O\nof O\na O\nmilkman O\nfrom O\na O\nworking O\nclass O\ndistrict O\nof O\nSt. B-LOC\nLouis I-LOC\n, O\nis O\na O\nconsummate O\ncongressional O\ninsider O\n, O\nsufficiently O\nskilled O\nin O\ncompromise O\nand O\nthe O\nways O\nof O\nthe O\nlegislature O\nto O\nmanage O\nthe O\noften-unruly O\nHouse B-ORG\nDemocrats B-MISC\n. O\n\nA O\nformer O\nlawyer O\n, O\nhe O\nwas O\nin O\nthe O\nfront O\nline O\nof O\nPresident O\nBill B-PER\nClinton I-PER\n's O\nbattle O\nwith O\nthe O\nRepublican-led B-MISC\nCongress B-ORG\nover O\nthe O\nbudget O\nbut O\nhas O\nopposed O\nthe O\npresident O\n's O\ndecision O\nto O\nsign O\nthe O\nRepublican-written B-MISC\nwelfare O\nreform O\nbill O\n. O\n\nHe O\nadvocated O\ntough O\naction O\nagainst O\nforeign O\ncountries O\nto O\ncut O\nU.S. B-LOC\ntrade O\ndeficits O\nbut O\nsometimes O\nbeen O\nout O\nof O\nstep O\nwith O\nthe O\nparty O\n's O\nliberal O\nwing O\n. O\n\nHe O\nwas O\nan O\nopponent O\nof O\nabortion O\nuntil O\n1986 O\nand O\nvoted O\nfor O\nPresident O\nRonald B-PER\nReagan I-PER\n's O\nbig O\ntax O\ncut O\nbill O\n. O\n\nGephardt B-PER\n, O\na O\nred-haired O\nsquare-jawed O\nman O\n, O\nis O\na O\nless O\nthan O\nfiery O\norator O\n. O\n\nHis O\n1988 O\nbid O\nfor O\nthe O\nDemocratic B-MISC\nnomination O\nonly O\ntook O\noff O\nafter O\nhe O\nrecreated O\nhimself O\nas O\na O\nfirebreathing O\nreformer O\nof O\nthe O\nestablishment O\n, O\nstanding O\nup O\nfor O\nblue O\ncollar O\nworkers O\nand O\nfarmers O\n. O\n\nTom B-PER\nDaschle I-PER\n-- O\nDaschle B-PER\n, O\n48 O\n, O\nwas O\nlargely O\nunknown O\noutside O\nWashington B-LOC\nand O\nhis O\nstate O\nof O\nSouth B-LOC\nDakota I-LOC\nwhen O\nhe O\nsurprisingly O\nbeat O\nmore O\nprominent O\nrivals O\nto O\nbecome O\nSenate B-ORG\nDemocratic B-MISC\nleader O\nafter O\nthe O\nparty O\nlost O\nits O\nmajority O\nto O\nthe O\nRepublicans B-MISC\nin O\n1994 O\n. O\n\nA O\nmild-mannered O\nand O\nyouthful O\nman O\nwho O\nrose O\nrapidly O\nafter O\nentering O\nthe O\nSenate B-ORG\nin O\n1987 O\n, O\nhe O\npresented O\nhimself O\nas O\na O\nMidwest B-LOC\nmoderate O\n, O\nas O\na O\nDemocratic B-MISC\nwinner O\nin O\na O\nRepublican B-MISC\nstate O\nable O\nto O\nunite O\nSenate B-ORG\nfactions O\n. O\n\nConcern O\nthat O\nhe O\nmight O\nbe O\nsteamrollered O\nby O\nthe O\nvastly O\nmore O\nexperienced O\nRepublican B-MISC\nleader O\nBob B-PER\nDole I-PER\nwas O\ndispelled O\nwhen O\nhe O\nshowed O\na O\ntough O\nedge O\n, O\noutmaneuvering O\nDole B-PER\nin O\na O\nwrangle O\nover O\nscrapping O\na O\ngas O\ntax O\nand O\nraising O\nthe O\nfederal O\nminimum O\nwage O\n. O\n\nIn O\nhis O\nearly O\nSenate B-ORG\nyears O\nhe O\nwas O\nseen O\nas O\na O\n\" O\nprairie O\npopulist O\n\" O\n, O\nworking O\non O\nlegislation O\nprotecting O\nfarmers O\n' O\nprices O\nand O\nalso O\non O\ncompensating O\nveterans O\nsickened O\nby O\nAgent B-MISC\nOrange I-MISC\ndefoliant O\nspraying O\nin O\nthe O\nVietnam B-MISC\nWar I-MISC\n. O\n\nDaschle B-PER\nwas O\na O\nkey O\nplayer O\nin O\nPresident O\nBill B-PER\nClinton I-PER\n's O\nfailed O\nattempt O\nat O\nsweeping O\nhealthcare O\nchanges O\nbut O\nwhen O\nhe O\nbecame O\nminority O\nleader O\nhe O\ndeclared O\nhe O\nwould O\nbe O\nno O\nwater-carrier O\nfor O\nthe O\nWhite B-LOC\nHouse I-LOC\n. O\n\nHe O\nhas O\nmade O\nclear O\nhe O\nopposed O\nClinton B-PER\n's O\nsigning O\nof O\nthe O\nRepublican-initiated B-MISC\nwelfare O\nreform O\nbill O\n. O\n\nHe O\nhas O\nspent O\nhis O\nadult O\nlife O\nin O\npolitics O\n, O\ncoming O\nto O\nCongress B-ORG\nas O\nan O\naide O\nin O\n1972 O\nafter O\nthree O\nyears O\nin O\nthe O\nAir B-ORG\nForce I-ORG\nand O\nthen O\nbeing O\nelected O\nto O\nthe O\nHouse B-ORG\nof I-ORG\nRepresentatives I-ORG\nhimself O\nin O\n1978 O\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nboy O\n, O\n13 O\n, O\naccused O\nof O\nmurdering O\nadoptive O\nmother O\n. O\n\nDALLAS B-LOC\n1996-08-26 O\n\nA O\n13-year-old O\nDallas B-LOC\nboy O\nhas O\nbeen O\ncharged O\nwith O\nmurdering O\nhis O\nadoptive O\nmother O\nover O\nthe O\nweekend O\n, O\npolice O\nsaid O\non O\nMonday O\n. O\n\nMargaret B-PER\nMcCullough I-PER\n, O\n55 O\n, O\nwas O\nfound O\ndead O\nin O\nher O\nhome O\non O\nSaturday O\nwith O\ngunshot O\nwounds O\nto O\nthe O\nhead O\n. O\n\nPolice O\n, O\nwho O\nat O\nfirst O\nthought O\nher O\nson O\nhad O\nbeen O\nkidnapped O\n, O\nfound O\nhim O\non O\nSunday O\nwith O\na O\nfriend O\nin O\nhis O\nmother O\n's O\ncar O\nin O\nOklahoma B-LOC\nand O\narrested O\nhim O\n. O\n\nA O\nshotgun O\nand O\na O\n.357 O\nhandgun O\nwere O\nfound O\nin O\nthe O\ncar O\n. O\n\nA O\npolice O\nspokesman O\nsaid O\nthe O\nboy O\nwas O\nbeing O\nquestioned O\n. O\n\" O\n\nThey O\nare O\ntalking O\nto O\nhim O\nnow O\nabout O\nthe O\nmotive O\nand O\neverything O\nelse O\n. O\n\" O\n\nMcCullough B-PER\nhad O\nadopted O\nthe O\nboy O\n, O\nwho O\nwas O\nthe O\ngrandson O\nof O\nher O\nlate O\nhusband O\n, O\nshortly O\nafter O\nhis O\nbirth O\nbut O\nneighbours O\nsaid O\nthey O\noften O\nhad O\nloud O\narguments O\n. O\n\n-DOCSTART- O\n\nPakistani B-MISC\nbourse O\nto O\nuse O\nnew O\nrecomposed O\nindex O\n. O\n\nKARACHI B-LOC\n, O\nPakistan B-LOC\n1996-08-26 O\n\nThe O\nKarachi B-ORG\nStock I-ORG\nExchange I-ORG\n( O\nKSE B-ORG\n) O\nsaid O\non O\nMonday O\nit O\nwould O\nintroduce O\na O\nnew O\nrecomposed O\nKSE-100 B-MISC\nindex O\non O\nSeptember O\n10 O\n. O\n\nA O\nKSE B-ORG\nstatement O\nsaid O\nthe O\nrecomposed O\nindex O\nwould O\nbe O\nmore O\nrepresentative O\n, O\ncapturing O\nmarket O\ncapitalisation O\nof O\n82.3 O\npercent O\n, O\nup O\nfrom O\n79.9 O\npercent O\npreviously O\n. O\n\n-- O\nKarachi B-LOC\nnewsroom O\n9221-5685192 O\n\n-DOCSTART- O\n\nNWE O\noil O\nproducts O\nmixed O\n, O\nholiday O\ndulls O\ntrade O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nNWE O\noil O\nproducts O\nwere O\nmixed O\non O\nMonday O\nbut O\nmarkets O\nwere O\nbecalmed O\nbecause O\nof O\na O\npublic O\nholiday O\nin O\nthe O\nUnited B-LOC\nKingdom I-LOC\n, O\ntraders O\nsaid O\n. O\n\nAn O\nexplosion O\nat O\nRepsol B-ORG\n's O\nPuertollano B-LOC\nrefinery O\n, O\nwhich O\nkilled O\nfour O\nworkers O\n, O\nhad O\nnot O\naffected O\noutput O\nof O\noil O\nproducts O\n, O\nan O\nofficial O\nsaid O\n. O\n\n\" O\nThe O\nplant O\nis O\nfunctioning O\nas O\nusual O\n, O\n\" O\nJose B-PER\nManuel I-PER\nPrieto I-PER\n, O\ndirector O\nof O\npersonnel O\n, O\ntold O\nSpanish B-MISC\nstate O\ntelevision O\n. O\n\nGasoline O\nprices O\nwere O\nnotionally O\nunchanged O\nfrom O\nFriday O\ndespite O\nsagging O\nNYMEX O\nnumbers O\n, O\nwith O\nthe O\narbitrage O\nwindow O\nto O\nthe O\nU.S. B-LOC\nconsidered O\nclosed O\nfor O\nthe O\nmoment O\n. O\n\nEurograde O\nbarges O\nwere O\noffered O\nat O\n$ O\n207 O\nfob O\nARA O\nfor O\nAmsterdam-Rotterdam B-LOC\nbarrels O\n, O\nand O\nat O\n$ O\n206 O\nfor O\nfull O\nARA O\nmaterial O\n. O\n\n\" O\nThere O\nis O\nno O\nmarket O\nat O\nthe O\nmoment O\n, O\n\" O\none O\nRotterdam B-LOC\ntrader O\nsaid O\n. O\n\" O\n\nMaybe O\nsentiment O\nis O\na O\nlittle O\nbit O\nweaker O\nbut O\nprices O\nhave O\nnot O\nchanged O\n. O\n\" O\n\nOutright O\ngas O\noil O\nprices O\nwere O\nnotionally O\nsofter O\nas O\nthe O\nNYMEX O\nheating O\noil O\ncontract O\nheaded O\nlower O\n, O\nand O\nfollowing O\nnews O\nthat O\nthe O\nIndian B-ORG\nOil I-ORG\nCorp I-ORG\n( O\nIOC B-ORG\n) O\nhad O\nissued O\na O\ntender O\nto O\nbuy O\nonly O\n120,000 O\ntonnes O\nof O\nhigh O\nspeed O\ndiesel O\nfor O\nOctober O\n. O\n\nAsian B-MISC\ntraders O\nhad O\nearlier O\nexpected O\nan O\nIOC B-ORG\ntender O\nfor O\naround O\n400,000 O\ntonnes O\n. O\n\nARA O\ngas O\noil O\nbarges O\nwere O\nquiet O\nalthough O\none O\ntrader O\nsaid O\nhe O\nhad O\nseen O\noffers O\nat O\n$ O\n1 O\na O\ntonne O\nover O\nSeptember O\nIPE O\nfor O\nprompt O\nbarrels O\n, O\nwhile O\nAntwerp B-LOC\nmaterial O\nwas O\navailable O\nfor O\n0-50 O\ncents O\nover O\nSeptember O\n. O\n\nThe O\nIOC B-ORG\ntender O\nhad O\n\" O\na O\nbearish O\nimpact O\n, O\nbut O\nnot O\na O\ngreat O\nimpact O\n, O\n\" O\none O\nGerman B-MISC\nplayer O\nsaid O\n. O\n\nFuel O\noil O\nmarkets O\nwere O\nalso O\nlistless O\n. O\n\nOffers O\nwere O\naround O\na O\ndollar O\na O\ntonne O\nhigher O\nat O\n$ O\n102 O\nfob O\nARA O\nbut O\nbids O\nwere O\nscarce O\n. O\n\n-- O\nNicholas B-PER\nShaxson I-PER\n, O\nLondon B-LOC\nnewsroom O\n+44 O\n171 O\n542 O\n8167 O\n\n-DOCSTART- O\n\nPrairies B-LOC\nsaw O\nno O\nfrost O\nMonday O\n, O\nnone O\nrest O\nof O\nweek O\n. O\n\nWINNIPEG B-LOC\n1996-08-26 O\n\nCanada B-LOC\n's O\nPrairies B-LOC\nsaw O\nno O\nfrost O\non O\nMonday O\nmorning O\nand O\nnone O\nwas O\nexpected O\nanywhere O\non O\nthe O\ngrainbelt O\nuntil O\nlate O\nin O\nthe O\nLabour B-MISC\nDay I-MISC\nlong O\nweekend O\n, O\nEnvironment B-ORG\nCanada I-ORG\nsaid O\n. O\n\n\" O\nApparently O\n, O\nwe O\n're O\nhome O\nfree O\nfor O\nthe O\nrest O\nof O\nthe O\nweek O\n. O\n\nWe O\n're O\nnot O\ncalling O\nfor O\nany O\nfrost O\nuntil O\nafter O\nthe O\nweekend O\nwhen O\nit O\nstarts O\nto O\ncool O\noff O\nin O\nnorthwestern O\nAlberta B-LOC\nafter O\nthe O\nweekend O\nprobably O\nMonday O\nor O\nTuesday O\n, O\n\" O\nmeteorologist O\nGerald B-PER\nMachnee I-PER\ntold O\nReuters B-ORG\n. O\n\nSprague B-LOC\n, O\nManitoba B-LOC\n, O\non O\nthe O\nMinnesota B-LOC\nborder O\nwas O\nthe O\ncold O\nspot O\nof O\nthe O\nPrairies B-LOC\nMonday O\nmorning O\nat O\n4.0 O\nCelsius B-MISC\n( O\n39.2 O\nF B-MISC\n) O\n. O\n\nTemperatures O\nat O\nground O\nlevel O\ncan O\nbe O\n2.0 O\nto O\n5.0 O\nCelsius B-MISC\nlower O\nthan O\nat O\nchest O\nlevel O\ndepending O\non O\nwindspeed O\n, O\nsky O\nconditions O\nand O\nground O\nsurface O\nmoisture O\n. O\n\nFreezing O\noccurs O\nat O\n0 O\nCelsius B-MISC\n( O\n32.0 O\nF B-MISC\n) O\n. O\n\nNorth B-LOC\nBattleford I-LOC\n, O\nSask B-LOC\n. O\n\n, O\nreported O\na O\nlow O\nof O\n5.0 O\nCelsius B-MISC\n( O\n41.0 O\nF B-MISC\n) O\nand O\nGrande B-LOC\nPrairie I-LOC\n, O\nAlta B-LOC\n. O\n\n, O\nin O\nthe O\nPeace B-LOC\nRiver I-LOC\nValley I-LOC\nreported O\n7.0 O\nCelsius B-MISC\n( O\n44.6 O\nF B-MISC\n) O\n. O\n\nMachnee B-PER\ndismissed O\ntalk O\nof O\nfrost O\nWednesday O\nby O\nproponents O\nof O\nthe O\n\" O\nfull O\nmoon O\n, O\nfrost O\nsoon O\n\" O\nschool O\nof O\nthought O\n. O\n\nLows O\non O\nAugust O\n28 O\nacross O\nthe O\nPrairies B-LOC\nshould O\nrange O\nfrom O\n8.0 O\nto O\n12.0 O\nCelsius B-MISC\nwith O\nhighs O\naround O\n30.0 O\nCelsius B-MISC\n. O\n\n-- O\nGilbert B-PER\nLe I-PER\nGras I-PER\n204 O\n947 O\n3548 O\n\n-DOCSTART- O\n\nBrush B-ORG\nWellman I-ORG\ncomments O\non O\nberyllium O\nlawsuits O\n. O\n\nCLEVELAND B-LOC\n1996-08-26 O\n\nBrush B-ORG\nWellman I-ORG\nInc I-ORG\nsaid O\nMonday O\nthat O\n10 O\nof O\n24 O\nlawsuits O\ninvolving O\nchronic O\nberyllium O\ndisease O\nhave O\nbeen O\ndismissed O\nsince O\nJuly O\n1 O\n. O\n\nThe O\nleading O\nU.S. B-LOC\nberyllium O\nproducer O\nsaid O\nin O\na O\nconference O\ncall O\nit O\nhas O\ntraditionally O\nbeen O\npro-active O\nregarding O\nthe O\nworkplace O\ndisease O\n, O\na O\nlung O\nailment O\nwhich O\ncan O\naffects O\na O\nsmall O\npercent O\nof O\npeople O\nwhose O\nimmune O\nsystems O\nare O\nsusceptible O\n. O\n\nOf O\nthe O\n14 O\nremaining O\nsuits O\n, O\n10 O\nwere O\nfiled O\nby O\nemployees O\nof O\nindustrial O\nBrush B-ORG\nWellman I-ORG\ncustomers O\nand O\nBrush B-ORG\nWellman I-ORG\nliability O\nin O\nsuch O\nsuits O\nis O\ntypically O\ncovered O\nby O\ninsurance O\n, O\nTimothy B-PER\nReid I-PER\n, O\nvice O\npresident O\nof O\ncorporate O\ncommunications O\n, O\nsaid O\non O\nthe O\ncall O\n. O\n\nThe O\ncompany O\nwas O\nresponding O\nto O\nan O\narticle O\nin O\nSunday O\n's O\nNew B-ORG\nYork I-ORG\nTimes I-ORG\n. O\n\nHe O\nsaid O\nthe O\narticle O\nlargely O\nreiterated O\ninformation O\nabout O\nthe O\nsuits O\nand O\nthe O\ndisease O\nwhich O\nhad O\npreviously O\nbeen O\nmade O\npublic O\nvia O\nSecurities B-ORG\nand I-ORG\nExchange I-ORG\nCommission I-ORG\nfilings O\nand O\nannual O\nreports O\n. O\n\n\" O\nBrush B-ORG\nWellman I-ORG\nhas O\nbeen O\na O\nleader O\nin O\ndealing O\nwith O\nhealth O\nand O\nsafety O\nissues O\n( O\nrelated O\nto O\nchronic O\nBeryllium O\ndisease O\n) O\nfor O\nnearly O\n50 O\nyears O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nWe O\nhave O\na O\nrecord O\nof O\ngoing O\nbeyond O\nregulatory O\nrequirements O\n... O\nand O\nwe O\nconsistently O\nshare O\nthe O\nmost O\ncurrent O\ninformation O\navailable O\n... O\nwith O\ncustomers O\nand O\nemployees O\n. O\n\" O\n\nThe O\ncustomer O\nemployee O\nsuits O\nwere O\nfiled O\nin O\n1990-95 O\n, O\nhe O\nsaid O\n. O\n\nA O\nclass O\naction O\nfiled O\nby O\na O\nformer O\nBrush B-ORG\nWellman I-ORG\nemployee O\nin O\nApril O\n1996 O\nwas O\ndismissed O\nin O\nJuly O\n, O\nhe O\nsaid O\n. O\n\nThe O\ncompany O\nis O\n\" O\nvigorously O\ndefending O\n\" O\nthe O\nremaining O\nfour O\nsuits O\nfiled O\nby O\nformer O\nand O\ncurrent O\nBrush B-ORG\nWellman I-ORG\nemployees O\n, O\nhe O\nsaid O\n. O\n\nAfter O\na O\ndelayed O\nopening O\n, O\nthe O\nstock O\nwas O\noff O\n1-1/2 O\nto O\n18-7/8 O\n. O\n\n-- O\nCleveland B-ORG\nNewsdesk I-ORG\n216-579-0077 O\n\n-DOCSTART- O\n\nSalomon B-ORG\ncuts O\nrefiner O\nQ3 O\nEPS O\nview O\non O\nmargin O\nconcern O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-26 O\n\nSalomon B-ORG\nBrothers I-ORG\nanalyst O\nPaul B-PER\nTing I-PER\nsaid O\nhe O\ncut O\nhis O\nshare O\nearnings O\nestimates O\non O\nrefiners O\nfor O\nthe O\nthird O\nquarter O\non O\nthe O\nbelief O\nthe O\ncompanies O\nwill O\nface O\nsharp O\nrevisions O\nin O\nrefining O\nand O\nmarketing O\nmargins O\n. O\n\nHe O\ncut O\nhis O\nthird-quarter O\nshare O\nearnings O\nestimate O\non O\n: O\n\n-- O\nDiamond B-ORG\nShamrock I-ORG\nInc I-ORG\nto O\n$ O\n0.38 O\nfrom O\n$ O\n0.73 O\nversus O\nthe O\nStreet O\n's O\nconsensus O\n$ O\n0.63 O\n\n-- O\nSun B-ORG\nCo I-ORG\nto O\n$ O\n0.15 O\nfrom O\n$ O\n0.85 O\nversus O\nthe O\nconsensus O\n$ O\n0.63 O\n\n-- O\nTosco B-ORG\nCorp I-ORG\nto O\n$ O\n0.95 O\nfrom O\n$ O\n1.03 O\nversus O\nthe O\nconsensus O\n$ O\n0.94 O\n\n-- O\nTotal B-ORG\nPetroleum I-ORG\n( I-ORG\nNorth I-ORG\nAmerica I-ORG\n) I-ORG\nLtd I-ORG\nto O\n$ O\n0.15 O\nfrom O\n$ O\n0.46 O\nversus O\nthe O\nconsensus O\n$ O\n0.33 O\n\n-- O\nAnd O\n, O\nValero B-ORG\nEnergy I-ORG\nCorp I-ORG\nto O\n$ O\n0.27 O\nfrom O\n$ O\n0.55 O\ncompared O\nwith O\nthe O\nconsensus O\n$ O\n0.40 O\n. O\n\n-DOCSTART- O\n\nPRESALE O\n- O\nMarion B-ORG\nCounty I-ORG\nBoard I-ORG\nof I-ORG\nEducation I-ORG\n, O\nW. B-LOC\nVa I-LOC\n. O\n\nAMT O\n: O\n3,250,000 O\nDATE O\n: O\n09/04/96 O\nNYC B-MISC\nTime I-MISC\n: O\n1200 O\nCUSIP O\n: O\n569399 O\n\nISSUER O\n: O\nMarion B-ORG\nCounty I-ORG\nBoard I-ORG\nof I-ORG\nEducation I-ORG\nST O\n: O\nWV O\n\nISSUE O\n: O\nPublic O\nSchool O\n, O\nSeries O\n1996 O\nTAX O\nSTAT:Exempt-ULT O\n\nM O\n/ O\nSP O\n/ O\nF O\n: O\nNA O\n/ O\nNA O\n/ O\nNA O\nBOOK O\nENTRY O\n: O\nY O\n\nENHANCEMENTS O\n: O\nNone O\nBANK O\nQUAL O\n: O\nY O\n\nDTD O\n: O\n09/01/96 O\nSURE O\nBID O\n: O\nN O\n\nDUE O\n: O\n5/1/98-02 O\nSR O\nMGR O\n: O\n\n1ST O\nCPN O\n: O\n05/01/97 O\n\nCALL O\n: O\nNon-Callable O\nNIC O\n\nDELIVERY O\n: O\n9/17/96 O\napprox O\nORDERS O\n: O\n\nPAYING O\nAGENT O\n: O\nWesBanco B-ORG\nBank I-ORG\nFairmont B-LOC\n, O\nFairmont B-LOC\n\nL.O. O\n: O\nSteptoe B-ORG\n& I-ORG\nJohnson I-ORG\n, O\nClarksburg B-LOC\n\nF.A. O\n: O\nFerris B-ORG\n, I-ORG\nBaker I-ORG\nWatts I-ORG\n, I-ORG\nInc. I-ORG\n, O\nCharleston B-LOC\n\nLAST O\nSALE O\n: O\n$ O\n7,330,000 O\n( O\nMBIA O\n) O\n3/1/90 O\n@ O\n6.14900 O\n% O\nNIC O\n; O\n4yrs O\n4mos O\nAvg O\n; O\nBBI-7.27 O\n% O\n\nYear O\nAmount O\nCoupon O\nYield O\nPrice O\nConc O\n. O\n\n1998 O\n575,000 O\n\n1999 O\n610,000 O\n\n2000 O\n650,000 O\n\n2001 O\n685,000 O\n\n2002 O\n730,000 O\n\nCOMPETITIVE O\nPRE-SALE O\nCONTRIBUTED O\nBY O\nJ.J. B-ORG\nKENNY I-ORG\nK-SHEETS O\n: O\n\n-DOCSTART- O\n\nBALANCE O\n- O\nOhio B-LOC\nrefunding O\nbonds O\nat O\n$ O\n290,000 O\n. O\n\nSTATE B-LOC\nOF I-LOC\nOHIO I-LOC\n\nRE O\n: O\n$ O\n70,375,000 O\n\n( O\nOHIO B-ORG\nBUILDING I-ORG\nAUTHORITY I-ORG\n) O\n\nSTATE O\nFACILITIES O\nREFUNDING O\nBONDS O\n\n1996 O\nSERIES O\nA O\n\nREPRICING O\nOF O\nTHE O\nBALANCE O\nOF O\nTHE O\nBONDS O\nIN O\nTHE O\nACCOUNT O\n. O\n\n9,215,000.00 O\n\nOCASEK O\nGOVERNMENT O\nOFFICE O\nBUILDING O\n\n( O\nC O\n) O\n\nMOODY B-ORG\n'S I-ORG\n: O\nA1 O\nS&P B-ORG\n: O\nAA- O\nFITCH O\n: O\nAA- O\n\nCONFIRMED O\nCONFIRMED O\n\nDelivery O\nDate O\n: O\n08/29/1996 O\n\nMaturity O\nBalance O\nCoupon O\nList O\n\n10/01 O\n/ O\n1998C O\n125M O\n4.50 O\n4.20 O\n\n6,045,000.00 O\n\nVERN O\nRIFFE O\nCENTER O\n\n( O\nD O\n) O\n\nMOODY B-ORG\n'S I-ORG\n: O\nA1 O\nS&P B-ORG\n: O\nAA- O\nFITCH O\n: O\nAA- O\n\nCONFIRMED O\nCONFIRMED O\n\nDelivery O\nDate O\n: O\n08/29/1996 O\n\nMaturity O\nBalance O\nCoupon O\nList O\n\n10/01 O\n/ O\n1998D O\n165M O\n4.50 O\n4.20 O\n\nGrand O\nTotal O\n: O\n290M O\n\nGoldman B-ORG\n, I-ORG\nSachs I-ORG\n& I-ORG\nCo I-ORG\n. O\n\nA.G. B-ORG\nEdwards I-ORG\n& I-ORG\nSons I-ORG\n, I-ORG\nInc I-ORG\n. O\n\nBanc B-ORG\nOne I-ORG\nCapital I-ORG\nCorporation I-ORG\n\nS.B.K- B-ORG\nBrooks I-ORG\nInvestment I-ORG\nCorp I-ORG\n. O\n\nSeasongood B-ORG\n& I-ORG\nMayer I-ORG\n\n-- O\nU.S. B-ORG\nMunicipal I-ORG\nDesk I-ORG\n, O\n212-859-1650 O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nWashington B-ORG\nPost I-ORG\nbusiness O\n- O\nAug O\n26 O\n. O\n\nWASHINGTON B-LOC\n1996-08-26 O\n\nThe B-ORG\nWashington I-ORG\nPost I-ORG\ncarried O\nonly O\nlocal O\nbusiness O\nstories O\non O\nAugust O\n26 O\n, O\n1996 O\n. O\n\n-DOCSTART- O\n\nChelsea B-PER\nmakes O\npolitical O\ndebut O\non O\nClinton B-PER\ntrain O\ntrip O\n. O\n\nCHILLICOTHE B-LOC\n, O\nOhio B-LOC\n1996-08-25 O\n\n- O\nChelsea B-PER\nClinton I-PER\n, O\nuntil O\nnow O\ncarefully O\nshielded O\nfrom O\nthe O\nexposure O\nof O\npublic O\nlife O\n, O\nmade O\nher O\npolitical O\ndebut O\non O\nSunday O\non O\nher O\nfather O\n's O\nwhistlestop O\ntrain O\ntrip O\n. O\n\nChelsea B-PER\n, O\n16 O\n, O\nwas O\nat O\nPresident O\nBill B-PER\nClinton I-PER\n's O\nside O\nas O\nhe O\nrode O\nthe O\nrails O\nthrough O\nparts O\nof O\nWest B-LOC\nVirginia I-LOC\n, O\nKentucky B-LOC\nand O\nOhio B-LOC\n, O\nand O\nwas O\nintroduced O\nat O\nevery O\nstop O\n. O\n\nShe O\neven O\nworked O\nropelines O\n, O\nshaking O\nhands O\nwith O\nexcited O\nfans O\n. O\n\nHillary B-PER\nRodham I-PER\nClinton I-PER\nsaw O\nher O\nhusband O\nand O\ndaughter O\noff O\non O\nthe O\ntrip O\nin O\nHuntington B-LOC\n, O\nWest B-LOC\nVirginia I-LOC\nand O\nthen O\nwent O\non O\nto O\nChicago B-LOC\nto O\nbegin O\na O\nrigorous O\nDemocratic B-MISC\nConvention I-MISC\nschedule O\n. O\n\nAsked O\nif O\nChelsea B-PER\nwould O\nhave O\na O\nprominent O\nrole O\nin O\nthe O\ncampaign O\n, O\nWhite B-LOC\nHouse I-LOC\nspokesman O\nMike B-PER\nMcCurry I-PER\nsaid O\n: O\n\" O\nShe O\n'll O\ndo O\nwhat O\nshe O\ndid O\ntoday O\nwhen O\nshe O\ncan O\n. O\n\nShe O\nhas O\nto O\ngo O\nback O\nto O\nschool O\n. O\n\" O\n\nThe O\npresident O\n's O\ndaughter O\nis O\ngoing O\ninto O\nher O\nsenior O\nyear O\nof O\nhigh O\nschool O\nat O\nSidwell B-ORG\nFriends I-ORG\nSchool I-ORG\n, O\na O\nprivate O\nschool O\nin O\nWashington B-LOC\n. O\n\nMcCurry B-PER\nsaid O\nChelsea B-PER\nhas O\nasked O\nto O\ngo O\non O\nthe O\ntrain O\ntrip O\nand O\nattend O\nthe O\nconvention O\nwhere O\nher O\nfather O\nwill O\nbe O\nrenominated O\n, O\nbut O\nsaid O\nher O\nexposure O\ndid O\nnot O\nsignal O\nthe O\nstart O\nof O\na O\nnew O\npolitical O\ncareer O\n. O\n\nChelsea B-PER\n\" O\nis O\na O\nvery O\npoised O\nyoung O\nlady O\n, O\nbut O\nshe O\n's O\nnot O\nthat O\nmuch O\ninterested O\nin O\npolitics O\n, O\n\" O\nthe O\nspokesman O\nsaid O\n. O\n\n-DOCSTART- O\n\nDutch B-MISC\nclosing O\nshare O\nmarket O\nreport O\n. O\n\nAMSTERDAM B-LOC\n1996-08-26 O\n\nDutch B-MISC\nshares O\ndrifted O\nto O\na O\nlower O\nclose O\non O\nMonday O\n, O\ndragged O\ndown O\nby O\nweakness O\nin O\nthe O\ndomestic O\nbond O\nmarket O\nand O\nturnover O\ndepressed O\nby O\nthe O\nUK B-LOC\nbank O\nholiday O\nand O\nlack O\nof O\nany O\nsignificant O\nU.S. B-LOC\neconomic O\ndata O\n. O\n\nThe O\nAEX B-MISC\nindex O\nof O\nleading O\nshares O\nclosed O\n4.54 O\npoints O\neasier O\nat O\n556.19 O\n, O\nthe O\nday O\n's O\nlow O\n. O\n\nThe O\nDutch B-MISC\nmarket O\nhad O\nbeen O\non O\nthe O\ndefensive O\nall O\nday O\nbut O\na O\nsofter O\nstart O\nto O\nWall B-LOC\nStreet I-LOC\ndid O\nlittle O\nto O\nboost O\nsentiment O\nin O\nlate O\ntrade O\n, O\ndealers O\nsaid O\n. O\n\n\" O\nIt O\nwas O\nalways O\ngoing O\nto O\nbe O\na O\ntough O\nday O\nwith O\nparticipation O\nso O\nlow O\n. O\n\nBut O\nthe O\nonly O\nthing O\nreally O\nworrying O\nthe O\nmarket O\nwas O\nthe O\nbonds O\n, O\nand O\nthat O\ndragged O\nus O\nlower O\n, O\n\" O\none O\ndealer O\nsaid O\n. O\n\nStocks O\nwere O\ndown O\nacross O\nthe O\nboard O\n, O\nwith O\nDutch B-ORG\nPTT I-ORG\ntopping O\nthe O\nvolume O\nlist O\nand O\nclosing O\ndown O\n1.90 O\nguilders O\nat O\n58.70 O\n. O\n\nThe O\npost O\nand O\ntelecoms O\nfirm O\nposted O\nan O\n8.5 O\npercent O\nrise O\nin O\nfirst O\nhalf O\nearnings O\non O\nFriday O\n, O\njust O\nbelow O\nanalysts O\n' O\nexpectations O\n. O\n\nIHC B-ORG\nCaland I-ORG\nreported O\nfirst O\nhalf O\nresults O\nwell O\nunder O\nforecasts O\non O\nMonday O\nand O\nthe O\nshares O\nsuffered O\nas O\na O\nresult O\n. O\n\nThey O\nwere O\ntrading O\nunchanged O\njust O\nbefore O\nthe O\nrelease O\nof O\nfigures O\nbut O\nclosed O\n2.40 O\nguilders O\ndown O\nat O\n80.70 O\nafter O\nit O\nreported O\nnet O\nprofits O\nof O\n34.9 O\nmillion O\nguilders O\nagainst O\n36.6 O\nmillion O\nlast O\nyear O\nand O\nestimates O\nranging O\nfrom O\n37.5 O\nto O\n47.2 O\nmillion O\n. O\n\nIHC B-ORG\nalso O\nforecast O\npost O\ntax O\nearnings O\nrising O\n21 O\npercent O\nfor O\nthe O\nfull O\nyear O\n. O\n\nBanking O\ngroup O\nING B-ORG\ntraded O\nex-dividend O\ntoday O\nand O\nfinished O\n0.60 O\nguilders O\nweaker O\nat O\n52.90 O\nas O\na O\nresult O\n. O\n\nBut O\nNutricia B-ORG\nshrugged O\noff O\nits O\nex-div O\ntag O\nto O\nsoar O\na O\nfurther O\n4.10 O\nguilders O\nto O\n214.40 O\ncontinuing O\nits O\nexplosive O\nrally O\nsparked O\nby O\nthe O\n51 O\npercent O\njump O\nin O\nfirst O\nhalf O\nnet O\nprofits O\nlast O\nweek O\n, O\nwhich O\nset O\nthe O\nmarket O\nalight O\non O\nFriday O\n, O\nsending O\nthe O\nshares O\nup O\n18.40 O\nat O\n210.00 O\nby O\nthe O\nclose O\n. O\n\nEngineering O\nconcern O\nStork B-ORG\nstarted O\nthe O\nday O\nwell O\nas O\nthe O\nshares O\nattracted O\nsome O\nfollow-through O\ninterest O\nto O\nthe O\nannouncement O\nlate O\non O\nFriday O\nthat O\nits O\nFokker B-ORG\nAviation I-ORG\nunit O\nhad O\nwon O\na O\nmajor O\norder O\n. O\n\nBut O\nthe O\nrally O\nwas O\nshort-lived O\nand O\nStork B-ORG\nended O\njust O\n0.20 O\nup O\nat O\n51.00 O\nguilders O\n. O\n\n-- O\nAmsterdam B-ORG\nNewsroom I-ORG\n+31 O\n20 O\n504 O\n5000 O\n\n-DOCSTART- O\n\nTapie B-PER\nto O\nquit O\nFrench B-MISC\nassembly O\nseat O\nas O\nfilm O\nopens O\n. O\n\nPARIS B-LOC\n1996-08-26 O\n\nFormer O\nbusinessman O\nand O\nsoccer O\nboss O\nBernard B-PER\nTapie I-PER\nsaid O\nthat O\nhe O\nwould O\ngive O\nup O\nhis O\nseat O\nin O\nthe O\nNational B-ORG\nAssembly I-ORG\nby O\nWednesday O\n, O\nthe O\nday O\na O\nfilm O\nby O\nClaude B-PER\nLelouche I-PER\nin O\nwhich O\nhe O\nstars O\nopens O\nin O\nFrance B-LOC\n. O\n\n\" O\nI O\nwill O\nno O\nlonger O\nbe O\ndeputy O\nby O\nthe O\ntime O\nthe O\nfilm O\nopens O\n, O\n\" O\nhe O\nsaid O\nin O\na O\nbroadcast O\ninterview O\n. O\n\n\" O\nJust O\nabout O\n, O\n\" O\nhe O\ntold O\nEurope B-ORG\n1 I-ORG\nradio O\nwhen O\nasked O\nwhether O\nhe O\nhad O\nsent O\nhis O\nletter O\nof O\nresignation O\nto O\nAssembly B-ORG\nspeaker O\nPhilippe B-PER\nSeguin I-PER\n. O\n\nA O\nSeguin B-PER\nspokeswoman O\nconfirmed O\nthat O\nno O\nletter O\nor O\ncall O\nhad O\nyet O\nbeen O\nreceived O\n. O\n\nTapie B-PER\n, O\n53 O\n, O\nwas O\nresigning O\njust O\nahead O\nof O\nexpected O\ngovernment O\naction O\nto O\neject O\nhim O\nfrom O\nthe O\nAssembly B-ORG\nfollowing O\na O\nfinding O\nby O\nthe O\nSupreme B-ORG\nCourt I-ORG\nthat O\nhe O\nwas O\nbankrupt O\nand O\nthus O\nineligible O\nfor O\npublic O\noffice O\nfor O\na O\nfive-year O\nperiod O\n. O\n\nTapie B-PER\n, O\nthe O\ntarget O\nof O\na O\nblizzard O\nof O\nlegal O\nactions O\nover O\nhis O\nnow-destroyed O\nbusiness O\nempire O\nand O\nthe O\nMarseille B-ORG\nsoccer O\nteam O\nhe O\nonce O\nran O\n, O\nhas O\na O\nstarring O\nrole O\nin O\nLelouche B-PER\n's O\n\" O\nHomme O\n, O\nfemmes O\n: O\nmode O\nd'emploi O\n\" O\n( O\nMen O\n, O\nwomen O\n: O\ninstructions O\nfor O\nuse O\n) O\n. O\n\nHe O\nplays O\na O\npower-hungry O\nlawyer O\nin O\nthe O\nmovie O\ndescribed O\nas O\n\" O\na O\ntender O\nand O\ncruel O\ncomedy O\n\" O\nby O\nLelouche B-PER\n, O\nwho O\nis O\nmaking O\nhis O\n35th O\nfilm O\n. O\n\n\" O\nI O\nhave O\npaid O\ntoo O\ndearly O\nfor O\nmixing O\ntwo O\ncareers O\n, O\n\" O\nTapie B-PER\nsaid O\n. O\n\" O\n\nIn O\nFrance B-LOC\n, O\nyou O\ncannot O\nbe O\na O\nfilm O\nartist O\nand O\na O\nnational O\npolitician O\nat O\nthe O\nsame O\ntime O\n. O\n\nThat O\nis O\nwhy O\nI O\nwill O\nno O\nlonger O\nbe O\ndeputy O\nby O\nthe O\ntime O\nthe O\nfilm O\nopens O\n. O\n\" O\n\nJustice O\nMinister O\nJacques B-PER\nToubon I-PER\nbegan O\nlast O\nmonth O\nthe O\nformal O\nprocess O\nof O\nejecting O\nTapie B-PER\nfrom O\nthe O\nFrench B-MISC\nparliament O\nas O\nwell O\nas O\nstripping O\nhim O\nof O\nhis O\nseat O\nin O\nthe O\nEuropean B-MISC\nparliament O\n. O\n\nThe O\nFrench B-MISC\nprocedure O\nwas O\nexpected O\nto O\nbe O\ncompleted O\nbefore O\nOctober O\n2 O\n, O\nwhen O\nthe O\nNational B-ORG\nAssembly I-ORG\nis O\nto O\nreconvene O\nafter O\na O\nsummer O\nbreak O\n, O\nbut O\nthe O\nEuropean B-MISC\nprocedure O\nwas O\nexpected O\nto O\ntake O\nlonger O\n. O\n\nTapie B-PER\n's O\nlawyer O\nhas O\nsaid O\nhe O\nintends O\nto O\nappeal O\nto O\nthe O\nEuropean B-ORG\nCourt I-ORG\nof I-ORG\nHuman I-ORG\nRights I-ORG\nin O\nan O\neffort O\nto O\nprevent O\nor O\ndelay O\nthe O\nloss O\nof O\nhis O\nEuropean B-MISC\nseat O\n. O\n\nBut O\nsuch O\nan O\nappeal O\n, O\neven O\nif O\nthe O\ncourt O\nwere O\nto O\naccept O\nthe O\ncase O\n, O\nwhich O\nit O\nis O\nnot O\nobliged O\nto O\ndo O\n, O\nwould O\nnot O\nsuspend O\nenforcement O\nof O\nthe O\nFrench B-MISC\njudgement O\nagainst O\nhim O\n. O\n\nTapie B-PER\nfaces O\na O\nprobable O\nspell O\nin O\nprison O\nafter O\nhe O\nloses O\nhis O\nparliamentary O\nimmunity O\n, O\nsince O\ntwo O\nappeal O\ncourts O\nhave O\nconfirmed O\njail O\nsentences O\nof O\neight O\nand O\nsix O\nmonths O\nagainst O\nhim O\nfor O\ntax O\nfraud O\nand O\nrigging O\na O\nsoccer O\nmatch O\n. O\n\nHe O\nis O\nappealing O\nin O\nboth O\ncases O\nto O\nthe O\nSupreme B-ORG\nCourt I-ORG\n. O\n\n-DOCSTART- O\n\nBank B-ORG\nof I-ORG\nFrance I-ORG\ndrains O\n3.9 O\nbln O\nFfr B-MISC\nat O\ntender O\n. O\n\nPARIS B-LOC\n1996-08-26 O\n\nThe O\nBank B-ORG\nof I-ORG\nFrance I-ORG\ndrained O\n3.9 O\nbillion O\nfrancs O\nat O\na O\nsecurities O\nrepurchase O\ntender O\nheld O\non O\nMonday O\nto O\nallocate O\nfunds O\nfor O\ninjection O\ninto O\nthe O\nmoney O\nmarket O\non O\nTuesday O\n. O\n\nIt O\naccepted O\nbids O\nfor O\n44.3 O\nbillion O\nfrancs O\nin O\nnew O\nliquidity O\n, O\n3.9 O\nbillion O\nless O\nthan O\nthe O\n48.2 O\nbillion O\nleaving O\nthe O\nmarket O\non O\nTuesday O\nwhen O\na O\nprevious O\npact O\nexpires O\n. O\n\nThe O\nnew O\npact O\nexpires O\non O\nSeptember O\n3 O\n. O\n\nThe O\nBank B-ORG\nof I-ORG\nFrance I-ORG\nsaid O\nit O\nallocated O\n13.4 O\nbillion O\nfrancs O\nto O\nbidders O\noffering O\nTreasury B-ORG\nbills O\nas O\ncollateral O\n, O\nsatisfying O\n3.4 O\npercent O\nof O\nsuch O\ndemand O\n. O\n\nIt O\nallotted O\na O\nfurther O\n30.9 O\nbillion O\nto O\nbidders O\nputting O\nup O\nprivate O\npaper O\n, O\nsatisfying O\n12.5 O\npercent O\nof O\nthis O\ndemand O\n. O\n\n-- O\nParis B-ORG\nNewsroom I-ORG\n+33 O\n1 O\n4221 O\n5452 O\n\n-DOCSTART- O\n\nRABOBANK B-ORG\n[ O\nRABN.CN O\n] O\nSEES O\nH2 O\nNET O\nGROWTH O\nUNDER O\n10 O\nPCT O\n. O\n\nAMSTERDAM B-LOC\n1996-08-26 O\n\nDutch B-MISC\nco-operative O\nbank O\nRabobank B-ORG\nNederland I-ORG\nBA I-ORG\n's O\nnet O\nprofit O\ngrowth O\nmight O\nslow O\nto O\nless O\nthan O\nthan O\n10 O\nyear O\npercent O\nin O\nthe O\nsecond O\nhalf O\nof O\n1996 O\n, O\nexecutive O\nboard O\nchairman O\nHerman B-PER\nWijffels I-PER\nsaid O\non O\nMonday O\n. O\n\nThe O\nunlisted O\nbank O\nearlier O\nannounced O\na O\n1996 O\ninterim O\nnet O\nprofit O\nof O\n853 O\nmillion O\nguilders O\n, O\nup O\n21.5 O\npercent O\non O\nthe O\n702 O\nmillion O\nguilders O\nreported O\nin O\nthe O\nfirst O\nhalf O\nof O\n1995 O\n. O\n\nHe O\nsaid O\nsecond-half O\nprofit O\ngrowth O\nwould O\ndepend O\non O\ncustomer O\ndemand O\nfor O\nloans O\n, O\nwhich O\nwas O\nalready O\neasing O\n, O\nand O\nthe O\nperformance O\nof O\nfinancial O\nmarkets O\n, O\nwhich O\nwere O\nstrong O\nin O\nthe O\nfirst O\nhalf O\nand O\nboosted O\nsecurities O\n, O\ntrading O\nand O\nunderwriting O\nincome O\n. O\n\n\" O\nWe O\nexpect O\nreasonable O\ngrowth O\nin O\nthe O\nsecond O\nhalf O\n. O\n\nMaybe O\nit O\nwill O\nbe O\nin O\nsingle-digits O\n, O\n\" O\nWijffels B-PER\ntold O\nReuters B-ORG\n. O\n\nHe O\nsaid O\ngrowth O\nin O\ncustomer O\ndemand O\nin O\nthe O\nfirst O\nhalf O\nwas O\n50 O\npercent O\nabove O\nnormal O\nbut O\nit O\nwas O\nhard O\nto O\nmaintain O\nthis O\npace O\n. O\n\nRabobank B-ORG\n's O\nnet O\nprofit O\nwas O\n1.43 O\nbillion O\nguilders O\nin O\n1995 O\n. O\n\nThe O\nbank O\nearlier O\nwarned O\nthat O\nprofit O\ngrowth O\nwould O\nslow O\nin O\nthe O\nsecond O\nhalf O\n, O\nciting O\nthe O\nincreasing O\nmomentum O\nin O\nprofit O\ngrowth O\nin O\nthe O\ncomparative O\nperiod O\nof O\n1995 O\nand O\nincreased O\ninvestment O\n. O\n\nBut O\nWijffels B-PER\nwas O\nunable O\nto O\nquantify O\nsecond O\nhalf O\ninvestment O\nto O\nimprove O\nand O\nextend O\ndomestic O\nand O\noffshore O\nservices O\n. O\n\n-- O\nGarry B-PER\nWest I-PER\n, O\nAmsterdam B-LOC\nnewsroom O\n+31 O\n20 O\n504 O\n5000 O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nFRANCE B-LOC\n- O\nLE B-ORG\nMONDE I-ORG\nAUG O\n26 O\n. O\n\nPARIS B-LOC\n1996-08-26 O\n\nThese O\nare O\nleading O\nstories O\nin O\nMonday O\n's O\nafternoon O\ndaily O\nLe B-ORG\nMonde I-ORG\n, O\ndated O\nAug O\n27 O\n. O\n\nFRONT O\nPAGE O\n\n-- O\nIpsos B-ORG\npoll O\nreports O\nmajority O\nof O\nFrench B-MISC\npublic O\nopinion O\nsympathises O\nwith O\nplight O\nof O\nAfricans B-MISC\nseeking O\nto O\nrenew O\nor O\nobtain O\nwork O\nand O\nresidence O\npermits O\n, O\ncalling O\ngovernment O\n\" O\nstubborn O\n, O\n\" O\n\" O\nconfused O\n\" O\nand O\n\" O\ncold-hearted O\n. O\n\" O\n\nBUSINESS O\nPAGES O\n\n-- O\nSNCF B-ORG\nrailway O\ntrade O\nunions O\nwant O\nrenegotiation O\nof O\ngovernment O\nbailout O\npackage O\n, O\nas O\nEuropean B-ORG\nUnion I-ORG\nprepares O\nmore O\nproposals O\nto O\nincrease O\ncompetition O\n. O\n\n-- O\nWorld O\nsteel O\nmarket O\nshows O\nsigns O\nof O\nupturn O\n. O\n\n-- O\nParis B-ORG\nNewsroom I-ORG\n+33 O\n1 O\n42 O\n21 O\n53 O\n81 O\n\n-DOCSTART- O\n\nATRIA B-ORG\nSEES O\nH2 O\nRESULT O\nUP O\nON O\nH1 O\n. O\n\nHELSINKI B-LOC\n1996-08-26 O\n\nFinnish B-MISC\nfoodstuffs O\ngroup O\nAtria B-ORG\nOy I-ORG\nsaid O\nin O\na O\nstatement O\non O\nMonday O\nit O\nexpects O\nits O\nresult O\nto O\nimprove O\nin O\nthe O\nsecond O\nhalf O\nof O\n1996 O\ncompared O\nto O\nthe O\nfirst O\nhalf O\n. O\n\n\" O\nThe O\nresult O\nof O\nthe O\nsecond O\nyear-half O\nis O\nexpected O\nto O\nimprove O\non O\nthe O\nearly O\npart O\nof O\nthe O\nyear O\n, O\n\" O\nAtria B-ORG\nsaid O\n. O\n\nAtria B-ORG\nsaid O\nearlier O\nits O\nJanuary-June O\nprofit O\nbefore O\nextraordinary O\nitems O\n, O\nappropriations O\nand O\ntaxes O\nfell O\nto O\n15 O\nmillion O\nmarkka O\nfrom O\n39 O\nin O\nthe O\nfirst-half O\nof O\n1995 O\n. O\n\n-DOCSTART- O\n\nBRIGHT-BELGIANS B-MISC\nSPEED O\nAFTER O\nSCHUMACHER B-PER\n'S O\nWIN O\n. O\n\nBRUSSELS B-LOC\n\nMichael B-PER\nSchumacher I-PER\n's O\nvictory O\nin O\nthe O\nBelgian B-MISC\nFormula B-MISC\nOne I-MISC\nGrand I-MISC\nPrix I-MISC\nat O\nSpa-Francorchamps B-LOC\nsparked O\na O\nspeeding O\nepidemic O\non O\nBelgian B-MISC\nroads O\nafter O\nthe O\nrace O\nwas O\nover O\n. O\n\nBelga B-ORG\nnews O\nagency O\nreported O\nthat O\npolice O\nchecked O\nmore O\nthan O\n3,000 O\ndrivers O\namd O\nbooked O\n222 O\nfor O\nspeeding O\non O\ntheir O\nway O\nhome O\nafter O\nthe O\nrace O\n. O\n\nSome O\nwere O\nclocked O\ndoing O\n180 O\nkilometres O\nan O\nhour O\n( O\n112 O\nmiles O\nper O\nhour O\n) O\n, O\nBelga B-ORG\nsaid O\n. O\n\nSchumacher B-PER\nwon O\nthe O\nrace O\nin O\n1 O\nhour O\n28 O\nminutes O\n15.125 O\nseconds O\nat O\nan O\naverage O\nspeed O\nof O\n208.442 O\nkm O\n/ O\nhour O\n( O\n130 O\nm.p.h. O\n) O\n. O\n\n-DOCSTART- O\n\nThai B-MISC\nPM O\nproposes O\nSept O\n18 O\nfor O\nno-confidence O\ndebate O\n. O\n\nBANGKOK B-LOC\n1996-08-26 O\n\nThai B-MISC\nPrime O\nMinister O\nBanharn B-PER\nSilpa-archa I-PER\non O\nMonday O\nproposed O\nSeptember O\n18 O\nas O\nthe O\ndate O\nfor O\nparliamentary O\ndebate O\non O\nan O\nopposition O\nno-confidence O\nmotion O\naccusing O\nhim O\nof O\nincompetence O\n. O\n\nThe O\npresident O\nof O\nparliament O\nhad O\nearlier O\nsaid O\nSeptember O\n11 O\ncould O\nbe O\nset O\nfor O\nthe O\ndebate O\n. O\n\nThe O\nopposition O\nmotion O\nagainst O\nBanharn B-PER\naccuses O\nhim O\nof O\nbeing O\nincompetent O\n, O\nlacking O\nethical O\nleadership O\nand O\nalleges O\nhis O\nadministration O\nis O\ncorrupt O\n. O\n\nHis O\ncritics O\nallege O\nhe O\nmay O\nbe O\nattempting O\nto O\ndelay O\nthe O\ndebate O\n. O\n\nBanharn B-PER\nhas O\ndenied O\nthe O\naccusations O\nand O\nsaid O\nhe O\nis O\nready O\nto O\nclear O\nhimself O\nin O\nparliament O\n. O\n\n\" O\nIn O\nmy O\nopinion O\nSeptember O\n18 O\nwould O\nbe O\na O\nconvenient O\ndate O\nfor O\nthe O\ngovernment O\nto O\nanswer O\nquestions O\n. O\n\nThis O\nhas O\nnothing O\nto O\ndo O\nwith O\nthe O\naccusation O\nthat O\nI O\nam O\ntrying O\nto O\nescape O\nthe O\ndebate O\n, O\n\" O\nBanharn B-PER\ntold O\nreporters O\nafter O\nmeeting O\ncoalition O\npartners O\n. O\n\nBanharn B-PER\n's O\n13-month-old O\n, O\nsix-party O\ncoalition O\ngovernment O\ncontrols O\n209 O\nseats O\nin O\nthe O\n391-seat O\nlower O\nhouse O\nof O\nparliament O\n. O\n\nPolitical O\ninfighting O\nwithin O\nBanharn B-PER\n's O\nChart B-ORG\nThai I-ORG\nparty O\nhas O\nraised O\ndoubts O\nwhether O\nhe O\ncan O\nhold O\nhis O\nsupporters O\ntogether O\nand O\ndefeat O\nthe O\nopposition O\nmotion O\n, O\npolitical O\nanalysts O\nsaid O\n. O\n\n\" O\nWe O\nare O\nstill O\nwaiting O\nto O\nfix O\na O\ndate O\n. O\n\nSeptember O\n18 O\nis O\nregarded O\nas O\ntentative O\nbecause O\nwe O\nstill O\nhave O\nnot O\nreceived O\nthe O\norder O\nto O\nfix O\nit O\non O\nthe O\nagenda O\n, O\n\" O\nsaid O\nan O\nofficial O\nat O\nparliament O\n's O\nagenda O\nsection O\n. O\n\nThe O\nlast O\nno-confidence O\ndebate O\nagainst O\nBanharn B-PER\n's O\ncoalition O\nin O\nMay O\nwas O\nwon O\nby O\nthe O\ngovernment O\n. O\n\n-DOCSTART- O\n\nFontaine B-ORG\n- O\n6mth O\nparent O\nforecast O\n. O\n\nTOKYO B-LOC\n1996-08-26 O\n\nSix O\nmonths O\nto O\nAugust O\n31 O\n, O\n1996 O\n\n( O\nin O\nbillions O\nof O\nyen O\nunless O\nspecified O\n) O\n\nLATEST O\nPREVIOUS O\nACTUAL O\n\n( O\nParent O\n) O\nFORECAST O\nFORECAST O\nYEAR-AGO O\n\nSales O\n3.30 O\n3.17 O\n2.75 O\n\nCurrent O\n400 O\nmillion O\n260 O\nmillion O\n231 O\nmillion O\n\nNet O\n170 O\nmillion O\n170 O\nmillion O\n142 O\nmillion O\n\nNOTE O\n- O\nFontaine B-ORG\nCo I-ORG\nLtd I-ORG\nsells O\nwomen O\n\" O\ns O\nfashion O\nwigs O\n. O\n\n-DOCSTART- O\n\nManila B-LOC\ninternational O\ncoconut O\noil O\nprices O\n. O\n\nMANILA B-LOC\n1996-08-26 O\n\nInternational B-ORG\nPhilippine I-ORG\ncoconut O\noil O\nprices O\nas O\nreported O\nby O\nthe O\nUnited B-ORG\nCoconut I-ORG\nAssociations I-ORG\nof I-ORG\nthe I-ORG\nPhilippines I-ORG\n( O\ndollars O\nper O\ntonne O\ncif O\nEurope B-LOC\n) O\n. O\n\nBuyers O\nSellers O\nLast O\nPrev O\n\nJulAug O\n775 O\n787.50 O\nunq O\nunq O\n\nAugSep O\n752.50 O\n758.75 O\nunq O\nunq O\n\nSepOct O\n733.75 O\n743.50 O\nunq O\nunq O\n\nOctNov O\nunq O\n740 O\nunq O\nunq O\n\nNovDec O\nunq O\n732.50 O\nunq O\nunq O\n\n-DOCSTART- O\n\nRESEARCH O\nALERT O\n- O\nAronkasei B-ORG\ncut O\n. O\n\nTOKYO B-LOC\n1996-08-26 O\n\nNomura B-ORG\nResearch I-ORG\nInstitute I-ORG\nLtd I-ORG\ndowngraded O\nAronkasei B-ORG\nCo I-ORG\nLtd I-ORG\nto O\na O\n\" O\n2 O\n\" O\nrating O\nfrom O\nits O\nprevious O\n\" O\n1 O\n\" O\n, O\nmarket O\nsources O\nsaid O\non O\nMonday O\n. O\n\nIn O\nits O\nthree-grade O\nrating O\nsystem O\n, O\nthe O\nresearch O\ninstitute O\nassigns O\na O\n\" O\n2 O\n\" O\nrating O\nto O\nissues O\nwhose O\nvalues O\nit O\nsees O\nmoving O\nwithin O\n10 O\npercentage O\npoints O\nin O\neither O\ndirection O\nof O\nthe O\nkey O\n225-share O\nNikkei B-MISC\naverage O\nover O\nthe O\nnext O\nsix O\nmonths O\n. O\n\nNomura B-ORG\nofficials O\nwere O\nnot O\nimmediately O\navailable O\nfor O\ncomment O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nTunisia B-LOC\n- O\nAug O\n26 O\n. O\n\nTUNIS B-LOC\n1996-08-26 O\n\nThese O\nare O\nthe O\nleading O\nstories O\nin O\nthe O\nTunisian B-MISC\npress O\non O\nMonday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nLA B-ORG\nPRESSE I-ORG\n\n- O\nEnglish B-MISC\nlangage O\nto O\nbe O\ntaught O\nas O\nof O\nthe O\neighth O\nyear O\nof O\nthe O\nprimary O\nschool O\ninstead O\nof O\nthe O\nthird O\nyear O\nof O\nthe O\nsecondary O\nschool O\n. O\n\nLE B-ORG\nTEMPS I-ORG\n\n- O\nInternational B-MISC\nFair I-MISC\nopens O\nin O\nthe O\nnorthern O\ncity O\nof O\nBeja B-LOC\nwith O\nthe O\nparticipation O\nof O\n16 O\nforeign O\ncountries O\n. O\n\n-DOCSTART- O\n\nU.N. B-ORG\nofficial O\nEkeus B-PER\nheads O\nfor O\nBaghdad B-LOC\n. O\n\nMANAMA B-LOC\n1996-08-26 O\n\nSenior O\nUnited B-ORG\nNations I-ORG\narms O\nofficial O\nRolf B-PER\nEkeus I-PER\nleft O\nBahrain B-LOC\nfor O\nBaghdad B-LOC\non O\nMonday O\nfor O\ntalks O\nwith O\nIraqi B-MISC\nofficials O\n, O\na O\nU.N. B-ORG\nspokesman O\nsaid O\n. O\n\nThe O\nspokesman O\nsaid O\nEkeus B-PER\n, O\nchairman O\nof O\nthe O\nUnited B-ORG\nNations I-ORG\nSpecial I-ORG\nCommission I-ORG\n( O\nUNSCOM B-ORG\n) O\n, O\nwould O\nspend O\ntwo O\nor O\nthree O\ndays O\nin O\nIraq B-LOC\nbut O\ndeclined O\nto O\ngive O\nfurther O\ndetails O\n. O\n\nU.N. B-ORG\noficials O\nhave O\nsaid O\nEkeus B-PER\nwould O\nhold O\ntalks O\nwith O\nIraqi B-MISC\nDeputy O\nPrime O\nMinister O\nTareq B-PER\nAziz I-PER\nand O\nother O\nofficials O\nas O\npart O\nof O\nan O\nagreement O\nIraq B-LOC\nreached O\nwith O\nthe O\nUnited B-ORG\nNations I-ORG\nin O\nJune O\nto O\nhold O\nhigher O\nlevel O\npolitical O\ntalks O\nwith O\nEkeus B-PER\n. O\n\nThe O\nSecurity B-ORG\nCouncil I-ORG\non O\nFriday O\nasked O\nIraq B-LOC\nto O\nstop O\nblocking O\narms O\ninspectors O\nsearch O\nfor O\nconcealed O\nweapons O\nor O\nmaterials O\nthey O\nbelieve O\nwere O\nbeing O\nshuttled O\naround O\nto O\navoid O\ndetection O\n. O\n\nDisarming O\nIraq B-LOC\nof O\nweapons O\nof O\nmass O\ndestruction O\nunder O\n1991 O\nGulf B-MISC\nWar I-MISC\nceasefire O\nterms O\nis O\na O\nprerequisite O\nbefore O\nthe O\nlifting O\nof O\ncrippling O\nsanctions O\nimposed O\non O\nIraq B-LOC\nin O\n1990 O\nfor O\ninvading O\nKuwait B-LOC\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nLebanon B-LOC\n- O\nAug O\n26 O\n. O\n\nBEIRUT B-LOC\n1996-08-26 O\n\nThese O\nare O\nthe O\nleading O\nstories O\nin O\nthe O\nBeirut B-LOC\npress O\non O\nMonday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nAN-NAHAR B-ORG\n\n- O\nThe O\nnorth O\nLebanon B-LOC\nelections O\n... O\n\nAlmost O\nno O\nchance O\nat O\nall O\nfor O\nany O\ncomplete O\nticket O\nto O\nwin O\naltogether O\nand O\nthe O\nresults O\nwill O\nweaken O\nsome O\nleaders O\n. O\n\n- O\nThe O\nsurprise O\n... O\n\nOpposition O\nBoutros B-PER\nHarb I-PER\nscoring O\nhigh O\nin O\npreliminary O\nresults O\nand O\nformer O\nprime O\nminister O\nOmar B-PER\nKarame I-PER\nmoves O\nbackwards O\n. O\n\n- O\nFears O\nof O\nan O\nIsraeli B-MISC\noperation O\ncauses O\nthe O\nredistribution O\nof O\nSyrian B-MISC\ntroops O\nlocations O\nin O\nLebanon B-LOC\n. O\n\nAS-SAFIR B-ORG\n\n- O\nParliament O\nSpeaker O\nBerri B-PER\n: O\nThe O\noccupied O\nsouth O\nshould O\nnot O\nbe O\nused O\nas O\na O\nwinning O\ncard O\nin O\nelections O\n. O\n\n- O\nPrices O\nof O\nalimentary O\ngoods O\nup O\n13.4 O\npercent O\nin O\n1996 O\n. O\n\nAL-ANWAR B-ORG\n\n- O\nChristian B-MISC\nMaronite I-MISC\nPatriarch O\nSfeir B-PER\n: O\nWe O\nfear O\na O\nmovement O\nfrom O\ndemocracy O\nto O\ndictatorship O\n. O\n\nAD-DIYAR B-ORG\n\n- O\nA O\ncabinet O\nminister O\n: O\n\" O\nLebanon B-ORG\nFirst I-ORG\n\" O\naims O\nat O\nsplitting O\nthe O\nSyrian-Lebanese B-MISC\npeace O\ntracks O\nwith O\nIsrael B-LOC\n. O\n\nNIDA'A B-ORG\nAL-WATAN I-ORG\n\n- O\nPrime O\nMinister O\nHariri B-PER\n: O\nElections O\nare O\nthe O\nbeginning O\nof O\na O\nlong O\npolitical O\nlife O\nwhich O\nwe O\nbegin O\nwith O\nan O\nincomplete O\nticket O\nof O\n17 O\ncandidates O\n. O\n\n- O\nThe O\nLebanese B-ORG\nAssociation I-ORG\nfor I-ORG\nthe I-ORG\nDemocracy I-ORG\nof I-ORG\nElections I-ORG\ncited O\n51 O\nincidents O\nof O\nviolation O\nin O\nthe O\nnorth O\nLebanon B-LOC\nround O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nMalta B-LOC\n- O\nAug O\n26 O\n. O\n\nVALLETTA B-LOC\n1996-08-26 O\n\nThese O\nare O\nthe O\nleading O\nstories O\nin O\nthe O\nMaltese B-MISC\npress O\non O\nMonday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nTHE B-ORG\nTIMES I-ORG\n\n- O\nVisitors O\nslam O\nbus O\nand O\ntaxi O\ndrivers O\nfor O\ncheating O\n. O\n\nTourists O\ninterviewed O\nin O\nMalta B-LOC\ncomplain O\nabout O\nover-charging O\n. O\n\nIN-NAZZJON B-LOC\n\n- O\nGovernment O\nconsidering O\nmeasures O\nfor O\nbetter O\nroad O\ndiscipline O\n. O\n\nMalta B-LOC\n, O\nwith O\na O\npopulation O\nof O\n365,000 O\n, O\nhas O\n195,000 O\nregistered O\nvehicles O\n, O\nwith O\n80,000 O\nnew O\ncars O\nhaving O\nbeen O\nintroduced O\non O\nthe O\ncongested O\nroads O\nin O\n10 O\nyears O\n. O\n\n- O\nFive O\npeople O\narrested O\nin O\nRomania B-LOC\nafter O\ndrugs O\ncontainer O\nfound O\nin O\nMalta B-LOC\n. O\n\nThe O\ncontainer O\n, O\nwith O\n7.5 O\ntonnes O\nof O\ncannabis O\n, O\nwas O\nfound O\nin O\nMalta B-LOC\nFreeport I-LOC\nin O\ntransit O\nfrom O\nSingapore B-LOC\nto O\nRomania B-LOC\n. O\n\nL-ORIZZONT B-LOC\n\n- O\nOpposition O\nleader O\nAlfred B-PER\nSant I-PER\non O\nsteep O\nrise O\nin O\ntaxes O\nover O\n10 O\nyears O\n. O\n\nHe O\nreiterates O\npromise O\nthat O\na O\nfuture O\nLabour B-ORG\ngovernment O\nwill O\nremove O\nVAT O\n. O\n\n-DOCSTART- O\n\nTamils B-MISC\ndemonstrate O\noutside O\nU.N. B-ORG\nheadquarters O\n. O\n\nGENEVA B-LOC\n1996-08-26 O\n\nThousands O\nof O\nTamils B-MISC\ndemonstrated O\noutside O\nthe O\nUnited B-ORG\nNations I-ORG\n' O\nEuropean B-MISC\nheadquarters O\nin O\nGeneva B-LOC\non O\nMonday O\nto O\nappeal O\nfor O\nU.N. B-ORG\nrecognition O\nof O\ntheir O\nfight O\nfor O\nindependence O\nfrom O\nSri B-LOC\nLanka I-LOC\n. O\n\nThe O\ndemonstrators O\n, O\nsaid O\nby O\npolice O\nto O\nnumber O\n6,000 O\n, O\nalso O\nurged O\nthe O\nrelease O\nof O\nNadarajah B-PER\nMuralidaran I-PER\n, O\nSwiss-based B-MISC\nleader O\nof O\nthe O\nthe O\nTamil B-ORG\nTiger I-ORG\nguerrillas O\n, O\nwho O\nhas O\nbeen O\nheld O\nin O\na O\nZurich B-LOC\njail O\nsince O\nApril O\non O\ncharges O\nof O\nextortion O\n. O\n\nThe O\ndemonstrators O\ndelivered O\nan O\nappeal O\nto O\nthe O\nU.N. B-ORG\nhuman O\nrights O\ncentre O\ndemanding O\nan O\nimmediate O\nend O\nto O\n\" O\nstate O\nterrorism O\n\" O\nagainst O\nTamils B-MISC\nand O\nthe O\nLiberation B-ORG\nTigers I-ORG\nof I-ORG\nTamil I-ORG\nEelam I-ORG\n( O\nLTTE B-ORG\n) O\n. O\n\n-DOCSTART- O\n\nFOCUS O\n- O\nEurobourses B-ORG\nend O\nmixed O\nbut O\nLondon B-LOC\nrecovers O\n. O\n\nLeonard B-PER\nSantorelli I-PER\n\nLONDON B-LOC\n1996-08-27 O\n\nEuropean B-MISC\nbourses O\nclosed O\nmixed O\non O\nTuesday O\nwith O\nLondon B-LOC\nclawing O\nback O\nmost O\nof O\nthe O\nday O\n's O\nlosses O\ndespite O\nan O\nunsteady O\nstart O\non O\nwall B-ORG\nStreet I-ORG\n, O\nhit O\nby O\ninflation O\nworries O\n. O\n\nThe O\ndollar O\nweakened O\nduring O\nthe O\nday O\nwith O\nmany O\ndealers O\nsidelined O\nbecause O\nof O\nuncertainty O\nover O\nTokyo B-LOC\n's O\nmonetary O\ndirection O\nahead O\nof O\nthe O\nimportant O\nJapanese B-MISC\nTankan B-ORG\neconomic O\nsurvey O\nout O\non O\nWednesday O\n. O\n\nBut O\nit O\nrecovered O\nat O\nthe O\nclose O\nof O\ntrade O\n. O\n\nStocks O\nin O\nLondon B-LOC\nstarted O\nthe O\nweek O\nbadly O\nafter O\na O\nthree-day O\nweekend O\n, O\nslipping O\n0.3 O\npercent O\n, O\nbut O\nbargain-hunters O\nlater O\nmoved O\nin O\nand O\nthe O\nFTSE B-MISC\nindex O\nrecovered O\nmost O\nof O\nthe O\nlost O\nground O\nto O\nend O\nonly O\njust O\nin O\nnegative O\nground O\n. O\n\nTuesday O\n's O\npatchy O\nshowing O\nin O\nLondon B-LOC\nfollowed O\na O\nstring O\nof O\nrecords O\nlast O\nweek O\n, O\nculminating O\nin O\nFriday O\n's O\ntrading O\nhigh O\nof O\n3,911 O\n, O\nfuelled O\nby O\na O\nwave O\nof O\nEuropean B-MISC\ninterest O\nrate O\ncuts O\n. O\n\nThe O\nLondon B-LOC\nbourse O\ndrew O\nlittle O\nhelp O\nfrom O\nthe O\nunsettled O\nmorning O\non O\nWall B-LOC\nStreet I-LOC\n, O\nwhich O\nslipped O\nin O\nand O\nout O\nof O\npositive O\nground O\nafter O\na O\nstronger-than-expected O\nAugust O\nconsumer O\nconfidence O\nreport O\nrefuelled O\ninflation O\nfears O\n, O\npulling O\nU.S. B-ORG\nTreasuries I-ORG\nback O\nfrom O\ntheir O\nearly O\npeaks O\n. O\n\nShortly O\nafter O\nthe O\nreport O\nappeared O\nshowing O\nthe O\nconfidence O\nindex O\nrising O\nto O\n109.4 O\nin O\nAugust O\nfrom O\na O\nrevised O\n107.0 O\nin O\nJuly O\n, O\nWall B-LOC\nStreet I-LOC\nrelinquished O\nvirtually O\nall O\nits O\nmorning O\ngains O\n. O\n\n\" O\nTreasuries B-ORG\nremain O\nvery O\nsensitive O\nto O\nany O\nindication O\nof O\na O\nstrong O\neconomy O\nand O\nwe O\n're O\nstill O\nin O\nthat O\nsummer O\ndoldrum O\nperiod O\nof O\nlight O\ntrading O\n, O\n\" O\nsaid O\nAlan B-PER\nAckerman I-PER\n, O\nmarket O\nstrategist O\nat O\nFahnestock B-ORG\n& I-ORG\nCo I-ORG\n. O\n\" O\n\nConsequently O\n, O\nstocks O\nand O\nbonds O\nare O\nboth O\nsubject O\nto O\nrapid O\nswings O\n. O\n\" O\n\nFrankfurt B-LOC\nwas O\nthe O\none O\nbright O\nspot O\nin O\nEurope B-LOC\n. O\n\nFloor O\ntrading O\nended O\nup O\n0.25 O\npercent O\nand O\nthe O\ncomputerised O\nIBIS B-MISC\nindex O\nclimbed O\nnearly O\n0.4 O\npercent O\n, O\ngiven O\na O\npush O\nby O\nthe O\nperformance O\nof O\nchemical O\nshares O\n. O\n\" O\n\nThe O\nmarket O\nis O\ntrading O\n100 O\npercent O\non O\nfundamentals O\nat O\nthe O\nmoment O\nas O\ninterest O\nrate O\nfantasy O\ndisappears O\n-- O\nit O\n's O\nall O\ncompany O\nnews O\n, O\n\" O\nsaid O\none O\ntrader O\n. O\n\nFrench B-MISC\nshares O\nended O\nslightly O\ndown O\namid O\ngrowing O\nunease O\nabout O\na O\ndifficult O\nautumn O\nfor O\nthe O\ngovernment O\nwhich O\nalso O\nweighed O\non O\nthe O\nfranc O\n, O\ndealers O\nsaid O\n. O\n\nBond O\nprices O\nwere O\nweaker O\nand O\nthe O\nfranc O\nwas O\nquoted O\nat O\n3.4210 O\nper O\nmark O\nfor O\nthe O\nfirst O\ntime O\nsince O\nAugust O\n13 O\nas O\nworries O\nabout O\nthe O\ngovernment O\n's O\nautumn O\nbudget O\nand O\na O\nweak O\nU.S. B-LOC\ncurrency O\nlifted O\nthe O\nmark O\nand O\nsqueezed O\nFrench B-MISC\ninvestments O\n. O\n\nThe O\ndollar O\n, O\nwhich O\ndropped O\nsharply O\non O\nMonday O\nbecause O\nof O\njitters O\nover O\nthe O\nJapanese B-MISC\nTankan B-ORG\nsurvey O\n, O\nweakened O\nfurther O\nin O\nquiet O\ntrading O\nbut O\nregained O\nlosses O\nto O\nend O\nthe O\nday O\nclose O\nto O\nMonday O\n's O\nlevels O\n. O\n\n\" O\nBesides O\nthe O\nTankan B-ORG\n, O\nthere O\n's O\nnothing O\nreally O\nuntil O\nthe O\nU.S. B-LOC\njobs O\nnumbers O\nnext O\nweek O\n, O\n\" O\nsaid O\na O\nUK B-LOC\nbank O\ncorporate O\ndealer O\n. O\n\" O\n\nThere O\nis O\nstill O\nthe O\nsummer O\nmalaise O\nhanging O\nover O\nthe O\nmarket O\n. O\n\" O\n\nForeign O\nexchange O\nmarkets O\nregard O\nthe O\nTankan B-ORG\nreport O\nas O\nan O\nimportant O\nindication O\nof O\nthe O\ncountry O\n's O\nfuture O\nmonetary O\npolicy O\ndirection O\n. O\n\nIf O\nit O\npoints O\nto O\nweakness O\nin O\nthe O\neconomy O\n, O\nthe O\nreport O\nwill O\nhelp O\nthe O\ndollar O\nregain O\nsome O\nlost O\nground O\nas O\nspeculation O\nof O\na O\nnear-term O\nrise O\nin O\nJapanese B-MISC\ninterest O\nrates O\nwill O\nevaporate O\n. O\n\nThe O\nJapanese B-MISC\ndiscount O\nrate O\nis O\ncurrently O\nat O\na O\nrecord O\nlow O\nof O\n0.5 O\npercent O\n. O\n\nThe O\ndollar O\nwas O\nalso O\npressured O\nby O\nthe O\nmark O\n's O\nstrength O\nagainst O\nEuropean B-MISC\ncurrencies O\namid O\nrenewed O\nconcerns O\nover O\nEurope B-LOC\n's O\neconomic O\nand O\nmonetary O\nunion O\n( O\nEMU B-MISC\n) O\ntimetable O\n. O\n\nCURRENCIES O\n\nThe O\ndollar O\nwas O\nat O\n1.4788 O\nmarks O\nand O\n107.74 O\nyen O\nat O\nthe O\nclose O\nof O\nEuropean B-MISC\ntrading O\ncompared O\nwith O\n1.4789 O\nmarks O\nand O\n107.55 O\nyen O\non O\nMonday O\n. O\n\nSTOCK O\nMARKETS O\n\nThe O\nFinancial B-MISC\nTimes-Stock I-MISC\nExchange I-MISC\nindex O\nof O\n100 O\nleading O\nBritish B-MISC\nshares O\nended O\n1.8 O\npoints O\nlower O\nat O\n3,905.7 O\n. O\n\nIn O\nParis B-LOC\n, O\nthe O\nCAC-40 B-MISC\nshare O\nindex O\nfinished O\ndown O\n2.43 O\nat O\n2,017.99 O\n. O\n\nThe O\n30-share O\nDAX B-MISC\nindex O\nin O\nFrankfurt B-LOC\nclosed O\nup O\n6.48 O\nat O\n2,558.84 O\n. O\n\nPRECIOUS O\nMETALS O\n\nGold O\nclosed O\nat O\n$ O\n388.55 O\nan O\nounce O\n, O\ncompared O\nwith O\nMonday O\n's O\nclose O\nof O\n$ O\n388.75 O\non O\ninternational O\nmarkets O\n. O\n\nSilver O\nended O\nup O\none O\ncent O\n$ O\n5.24 O\n. O\n\n-DOCSTART- O\n\nMore O\nhostages O\nfreed O\nfrom O\nhijacked O\nSudanese B-MISC\nplane O\n. O\n\nSTANSTED B-LOC\n, O\nEngland B-LOC\n1996-08-27 O\n\nArmed O\nhijackers O\nbelieved O\nto O\nbe O\nIraqis B-MISC\nreleased O\nbetween O\n60 O\nand O\n70 O\npeople O\non O\nTuesday O\nfrom O\na O\nSudan B-ORG\nAirways I-ORG\nplane O\ncarrying O\n199 O\npassengers O\nand O\ncrew O\nthat O\nlanded O\nin O\nLondon B-LOC\nafter O\nbeing O\ndiverted O\non O\na O\nflight O\nfrom O\nKhartoum B-LOC\nto O\nAmman B-LOC\n, O\nauthorities O\nsaid O\n. O\n\nA O\nspokesman O\nfor O\nStansted B-LOC\nairport O\nsaid O\nthat O\nthe O\nunidentified O\nhijackers O\nwere O\ndemanding O\nto O\nsee O\na O\nBritish-based B-MISC\nmember O\nof O\nthe O\nIraqi B-ORG\nCommunity I-ORG\nAssociation I-ORG\n, O\ncalled O\nMr O\nSadiki B-PER\n, O\nand O\nthat O\npolice O\nwere O\ntrying O\nto O\ntrace O\nhim O\n. O\n\nPolice O\nspokeswoman O\nKim B-PER\nWhite I-PER\nsaid O\npolice O\nhad O\nalready O\ncontacted O\nSadiki B-PER\nand O\nwere O\ntrying O\nto O\narrange O\nto O\nbring O\nhim O\nto O\nStansted B-LOC\n, O\n30 O\nmiles O\n( O\n48 O\nkm O\n) O\nnorth-east O\nof O\nLondon B-LOC\n, O\nto O\ntalk O\nto O\nthe O\nhijackers O\n. O\n\nThe O\nairport O\nspokesman O\nsaid O\nthe O\nsix O\nhijackers O\n, O\nwho O\npolice O\nsaid O\nwere O\narmed O\nwith O\ngrenades O\nand O\npossibly O\nother O\nexplosives O\n, O\nwere O\nbelieved O\nto O\nbe O\nIraqi B-MISC\nnationals O\n. O\n\nThe O\nhijackers O\nstarted O\nto O\nrelease O\npeople O\nfor O\nthe O\nAirbus B-MISC\nplane O\nin O\nbatches O\nof O\n10 O\n, O\nstarting O\nwith O\nwomen O\nand O\nchildren O\n, O\nin O\nwhat O\npolice O\ndescribed O\nas O\na O\n\" O\ncontrolled O\nrelease O\n\" O\n. O\n\nPolice O\nsaid O\nmost O\nof O\nthe O\npassengers O\nwere O\nSudanese B-MISC\nbut O\nthat O\nthere O\nwere O\nalso O\nan O\nunknown O\nnumber O\nof O\nIraqis B-MISC\n, O\nJordanians B-MISC\n, O\nPalestinians B-MISC\n, O\nSyrians B-MISC\nand O\nSaudis B-MISC\n. O\n\nLater O\nthey O\nsaid O\nthe O\nnumber O\nof O\npassengers O\nreleased O\nfrom O\nthe O\nplane O\nhad O\nreached O\n80 O\n. O\n\n-DOCSTART- O\n\nFEATURE O\n- O\n\" O\nEco O\nterrorists O\n\" O\ntarget O\nUK B-LOC\nbuilders O\n. O\n\nEdna B-PER\nFernandes I-PER\n\nLONDON B-LOC\n1996-08-27 O\n\nEcological O\nwarfare O\nhas O\nbroken O\nout O\nacross O\nthe O\nBritish B-MISC\nconstruction O\nindustry O\n, O\nstriking O\nsome O\nof O\nthe O\nbiggest O\ncorporates O\nas O\nactivists O\ngive O\nup O\npeaceful O\nprotests O\nand O\nseek O\nto O\nhit O\nbuilders O\nwhere O\nit O\nhurts O\n-- O\ntheir O\nprofit O\nmargins O\n. O\n\nDescribed O\nby O\none O\nBritish B-MISC\ncompany O\nas O\n\" O\neco-terrorism O\n\" O\n, O\nit O\nis O\nseen O\nas O\nthe O\nnew O\nbusiness O\nrisk O\nof O\nthe O\n1990s O\n. O\n\nFamous O\nnames O\nlike O\nTarmac B-ORG\nPlc I-ORG\n, O\nCostain B-ORG\nGroup I-ORG\nPlc I-ORG\nand O\nARC B-ORG\n, O\na O\nunit O\nof O\nconglomerate O\nHanson B-ORG\nPlc I-ORG\n, O\nhave O\nall O\nbeen O\ntargeted O\n. O\n\nActivist O\ngroups O\nare O\nno O\nlonger O\nseen O\nby O\nBritish B-MISC\nfirms O\nas O\na O\nharmless O\n, O\nbadly O\norganised O\nragbag O\nof O\nstudents O\nand O\nhippies O\n. O\n\n\" O\nYou O\nonly O\nhave O\nto O\nsee O\nthem O\nin O\naction O\nat O\nprotests O\n, O\n\" O\nsaid O\nDavid B-PER\nHarding I-PER\n, O\nspokesman O\nat O\nARC B-ORG\n, O\nHanson B-ORG\n's O\naggregates O\ncompany O\n. O\n\" O\n\nThey O\nwalk O\naround O\nwith O\nmobile O\nphones O\nand O\ncamera O\nequipment O\n, O\nthey O\ncommunicate O\nand O\ngather O\nsupport O\nfor O\ndemos O\nvia O\nthe O\nInternet B-MISC\n-- O\nwe O\n're O\ntalking O\nabout O\na O\nhighly O\nsophisticated O\norganisation O\n. O\n\" O\n\nOne O\nroad O\nprotestor O\nunder O\nthe O\ncodename O\nSteady B-PER\nEddie I-PER\ntold O\nconstruction O\njournal O\n\" O\nBuilding B-ORG\n\" O\nearlier O\nthis O\nyear O\n, O\n\" O\nIf O\nit O\ncomes O\ndown O\nto O\nfull-scale O\neconomic O\nwarfare O\n, O\nwe O\nwill O\naim O\nto O\ndrive O\nthem O\nout O\nof O\nbusiness O\n. O\n\" O\n\nAs O\nwell O\nas O\nfinancial O\nthreats O\n, O\ncompanies O\nalso O\nemphasise O\nthe O\n\" O\nterror O\n\" O\ntactics O\nused O\n. O\n\nCostain B-ORG\n's O\ncontract O\nto O\nbuild O\nthe O\ncontroversial O\nNewbury B-LOC\nbypass O\n, O\nwhich O\nruns O\nthrough O\na O\nconservation O\narea O\n, O\nhas O\nled O\nto O\nviolent O\nprotests O\ndelaying O\nbuilding O\n, O\nbomb O\nthreats O\n, O\nstaff O\nintimidation O\nand O\npicketing O\nof O\nchief O\nexecutive O\nAlan B-PER\nLovell I-PER\n's O\nhome O\n. O\n\nA O\nCostain B-ORG\nspokesman O\ntold O\nReuters B-ORG\n: O\n\" O\nWe O\n've O\nhad O\nall O\nsorts O\nof O\nprotests O\nat O\nthe O\nhead O\noffice O\nand O\nthe O\nchief O\nexecutive O\n's O\nhouse O\n. O\n\nBut O\nit O\n's O\nwhen O\nit O\ngets O\nto O\nthe O\n( O\nemployee O\n) O\nfamilies O\n-- O\nthat O\nit O\ngoes O\nacross O\nthe O\nline O\n. O\n\" O\n\nTactics O\nused O\nby O\nsome O\nunderground O\ngroups O\nincluding O\nthe O\ncryptic O\nBerkshire B-ORG\nWood I-ORG\nElves I-ORG\n, O\nwhich O\ndistribute O\nleaflets O\nwith O\ninstructions O\non O\nhome-made O\nexplosives O\n, O\nare O\nnow O\nthe O\nsubject O\nof O\na O\npolice O\ninvestigation O\n. O\n\nOther O\nlarger O\nactivist O\ngroups O\ninclude O\nEarth B-ORG\nFirst I-ORG\n, O\nThe B-ORG\nLand I-ORG\nis I-ORG\nOurs I-ORG\n, O\nAlarm B-ORG\nUK I-ORG\nand O\nRoad B-ORG\nAlert I-ORG\n. O\n\nThe O\ngroups O\nhave O\ntargeted O\nspecific O\nprojects O\nlike O\nthe O\nNewbury B-LOC\nbypass O\nand O\nthe O\nM3 B-LOC\nmotorway O\nthrough O\nTwyford B-LOC\nDown I-LOC\nin O\nthe O\nsouthern O\ncounty O\nof O\nHampshire B-LOC\n. O\n\nBut O\nthey O\nare O\nalso O\ncampaigning O\non O\nbroader O\nissue O\nsuch O\nas O\nstopping O\nthe O\ngovernment O\nroad O\nbuilding O\nprogramme O\nand O\nout-of-town O\nsuperstores O\nwhich O\nthey O\nsay O\ncreate O\nmore O\ntraffic O\n, O\npollution O\nand O\ndamage O\nlocal O\ncommunities O\n. O\n\nThe O\ngovernment O\nhas O\nslashed O\nits O\nroad-building O\nspending O\n. O\n\nAlthough O\nprotests O\nmay O\nhave O\ncontributed O\nto O\nthe O\ndecision O\nit O\nhas O\nbeen O\nseen O\nprimarily O\nas O\neconomic O\nrather O\nthan O\necological O\n. O\n\nGraham B-PER\nWatts I-PER\n, O\nchief O\nexecutive O\nof O\nthe O\nConstruction B-ORG\nIndustry I-ORG\nCouncil I-ORG\n, O\nsaid O\n: O\n\" O\nI O\ndo O\nn't O\nthink O\nmany O\nfirms O\ninvolved O\nin O\ntendering O\nfor O\nsensitive O\nprojects O\nrealise O\nthe O\nimpact O\nenvironmental O\nactivity O\nhas O\non O\nthe O\ncost O\nof O\nrunning O\na O\nproject O\n. O\n\n\" O\nBut O\nthey O\nare O\nmore O\nalert O\nthan O\nthey O\nwere O\n3-4 O\nyears O\nago O\n. O\n\nThere O\n's O\nno O\ndoubt O\nit O\n's O\na O\nbig O\nissue O\nnow O\n. O\n\" O\n\nHe O\nsays O\nthe O\ndamage O\ncomes O\nin O\ntwo O\nforms O\n: O\n\" O\nTangible O\n-- O\nin O\nthe O\nform O\nof O\nextra O\ncosts O\n, O\nadditional O\nsecurity O\n, O\nthreats O\nto O\nstaff O\nand O\nthe O\nmore O\nintangible O\ndamage O\ncaused O\nby O\nnegative O\npublicity O\n. O\n\" O\n\nWatts B-PER\nsaid O\nthe O\ncost O\nof O\nprotesting O\ncan O\nbe O\nheavy O\nonce O\nthe O\ncompany O\nis O\nlocked O\ninto O\na O\ncontract O\n. O\n\n\" O\nI O\ndo O\noften O\nhear O\non O\nthe O\nindustry O\ncircuit O\nof O\ntales O\nwhere O\nthe O\ncompany O\ntenders O\nat O\nlow O\nmargins O\nand O\nthe O\ndemonstrations O\nwhich O\nfollow O\nmeans O\nthey O\nare O\nrunning O\nthe O\nproject O\nat O\na O\nloss O\n. O\n\" O\n\nARC B-ORG\nsays O\nit O\n's O\nnot O\njust O\ncontractors O\nin O\nthe O\nfront O\nline O\nbut O\nalso O\nsuppliers O\nlike O\nitself O\n. O\n\nIts O\nown O\nquarries O\ncame O\nunder O\nattack O\nafter O\nit O\nemerged O\nthat O\nit O\nmay O\nbe O\na O\nsupplier O\nfor O\nthe O\nNewbury B-LOC\nbypass O\n. O\n\n\" O\nIt O\nwas O\ncalled O\nthe O\n\" O\nFirst B-MISC\nBattle I-MISC\nof I-MISC\nthe I-MISC\nNewbury I-MISC\nbypass I-MISC\n' O\n, O\n\" O\nsaid O\nARC B-ORG\n's O\nHarding B-PER\n. O\n\n\" O\nWe O\nhad O\n300 O\nEarth B-ORG\nFirst I-ORG\nprotestors O\ninvade O\nand O\noccupy O\nour O\nsite O\n. O\n\nHundreds O\nof O\nthousands O\nof O\npounds O\n( O\ndollars O\n) O\nof O\ndamage O\nwas O\ndone O\nin O\none O\nday O\n. O\n\nPlus O\nthere O\nwas O\nthe O\nknock-on O\ncost O\nof O\nlost O\nproduction O\nand O\nextra O\nsecurity O\nin O\nfuture O\n. O\n\" O\n\nSimon B-PER\nBrown I-PER\n, O\nanalyst O\nat O\ninvestement O\nbank O\nUBS B-ORG\n, O\nsaid O\nthis O\nnew O\nphenomenon O\nhas O\nled O\nto O\na O\nchange O\nin O\nthe O\nway O\nthe O\nindustry O\nevaluates O\nproject O\nrisk O\n. O\n\n\" O\nWhen O\ntalking O\nto O\nTarmac B-ORG\nabout O\nthe O\nM3 B-LOC\nlink O\n( O\nthrough O\nTwyford B-LOC\nDown I-LOC\n) O\nthey O\nmade O\nit O\nfairly O\nclear O\nthat O\ntheir O\nrisk O\nassessment O\nmethods O\nhave O\nbeen O\nchanged O\nand O\nnow O\ninvolve O\na O\nvery O\nclear O\nenvironmental O\nrisk O\nanalysis O\n. O\n\" O\n\nHarding B-PER\nsays O\nothers O\nhave O\ndone O\nthe O\nsame O\n. O\n\" O\n\nAs O\na O\nresult O\nof O\neco-terrorism O\nwe O\nare O\nlooking O\nat O\ncontroversial O\njobs O\nmore O\nclosely O\nto O\nsee O\nif O\nthe O\nprofit O\nmargins O\nare O\nwide O\nenough O\nto O\ncover O\nthings O\nlike O\nextra O\nsecurity O\n. O\n\" O\n\nFor O\nan O\nindustry O\nalready O\nsuffering O\nfrom O\nrazor-thin O\nmargins O\n, O\novercapacity O\nand O\nstagnant O\ndemand O\n, O\neco-terrorism O\nis O\nthe O\nlatest O\nbizarre O\ntwist O\nin O\nthe O\nconstruction O\nsector O\n's O\ntale O\nof O\nwoe O\n. O\n\n-DOCSTART- O\n\nLondon B-MISC\nCarnival I-MISC\nends O\nin O\nhigh O\nspirits O\n. O\n\nLONDON B-LOC\n1996-08-26 O\n\nLondon B-LOC\n's O\nannual O\nNotting B-MISC\nHill I-MISC\nCarnival I-MISC\n, O\nthe O\nlargest O\nin O\nEurope B-LOC\nand O\nsecond O\nin O\nthe O\nworld O\nonly O\nto O\nRio B-LOC\n, O\nended O\npeacefully O\non O\nMonday O\nwith O\nan O\nestimated O\n800,000 O\nrevellers O\nsinging O\nand O\ndancing O\nthe O\nday O\naway O\nin O\nhigh O\nspirits O\n. O\n\nPolice O\nsaid O\nthey O\nmade O\n30 O\narrests O\nand O\nthere O\nwere O\ntwo O\nstabbings O\n. O\n\nBut O\nthere O\nwas O\nno O\nrepeat O\nof O\nthe O\nugly O\nscenes O\nthat O\nused O\nto O\nscar O\nthe O\nstreet O\nfestival O\n, O\nand O\npolice O\npraised O\nthe O\ncrowds O\nover O\nthe O\ntwo O\ndays O\nof O\nfestivities O\nas O\ngood-natured O\n. O\n\nAround O\n400 O\npolice O\nwere O\nwounded O\nin O\nriots O\nin O\n1976 O\nwhen O\nthe O\ncarnival O\n, O\nnow O\nin O\nits O\n31st O\nyear O\n, O\nacquired O\nits O\ndarker O\nreputation O\nfrom O\nwhich O\nit O\nis O\nnow O\nonly O\nslowly O\nrecovering O\n. O\n\nShopkeepers O\nstill O\nboard O\nup O\ntheir O\nwindows O\nand O\nmany O\nresidents O\nleave O\ntown O\nfor O\nthe O\nweekend O\n, O\nbut O\nfor O\nfour O\nor O\nfive O\nyears O\nthere O\nhas O\nbeen O\nno O\ndisorder O\nand O\nrelatively O\nlittle O\ncrime O\n. O\n\n-DOCSTART- O\n\nOFFICIAL B-ORG\nJOURNAL I-ORG\nCONTENTS O\n- O\nOJ B-ORG\nC O\n248 O\nOF O\nAUGUST O\n26 O\n, O\n1996 O\n. O\n\n* O\n\n( O\nNote O\n- O\ncontents O\nare O\ndisplayed O\nin O\nreverse O\norder O\nto O\nthat O\nin O\nthe O\nprinted O\nJournal B-ORG\n) O\n\n* O\n\nANNEX O\n\nSTATEMENT O\nOF O\nTHE O\nCOUNCIL O\n'S O\nREASONS O\n\nANNEX O\nI O\n\nANNEX O\nA O\n\nSTATEMENT O\nOF O\nTHE O\nCOUNCIL O\n'S O\nREASONS O\nEND O\nOF O\nDOCUMENT O\n. O\n\n-DOCSTART- O\n\nIndonesia B-LOC\nnewspaper O\nreports O\ncentral O\nbank O\nscandal O\n. O\n\nJAKARTA B-LOC\n1996-08-27 O\n\nIndonesia B-LOC\n's O\ncentral O\nbank O\nsuffered O\nseven O\nbillion O\nrupiah O\n( O\n$ O\n2.9 O\nmillion O\n) O\nin O\nlosses O\nresulting O\nfrom O\nfake O\ntransactions O\n, O\nthe O\nJakarta B-ORG\nPost I-ORG\nreported O\non O\nTuesday O\n. O\n\nA O\nBank B-ORG\nIndonesia I-ORG\nspokeswoman O\nconfirmed O\nthe O\nnewspaper O\nreport O\nbut O\ndeclined O\nto O\ngive O\nfurther O\ndetails O\n. O\n\nThe O\nbank O\n's O\ngovernor O\nSudradjat B-PER\nDjiwandono I-PER\nwas O\nquoted O\nas O\nsaying O\non O\nMonday O\nabout O\n5.4 O\nbillion O\nrupiah O\nof O\nthe O\nseven O\nbillion O\nrupiah O\nhad O\nbeen O\nrecovered O\n. O\n\nThe O\nnewspaper O\nsaid O\nit O\nwas O\nthe O\ncentral O\nbank O\n's O\nfirst O\npublic O\nscandal O\nin O\nits O\n43-year O\nhistory O\n. O\n\nThe O\npaper O\nsaid O\nfive O\npeople O\nhad O\nbeen O\narrested O\nand O\npolice O\nwere O\nlooking O\nfor O\ntwo O\nmore O\nsuspects O\n. O\n\n( O\n$ O\n1 O\n= O\n2,341 O\nrupiah O\n) O\n\n-DOCSTART- O\n\nGOLF O\n- O\nPLAYERS O\nDIVIDED O\nON O\nCART O\nREQUEST O\nFOR O\nOLAZABAL B-PER\n. O\n\nNORTHAMPTON B-LOC\n, O\nEngland B-LOC\n1996-08-27 O\n\nSeve B-PER\nBallesteros I-PER\nand O\nColin B-PER\nMontgomerie I-PER\nare O\ndivided O\non O\nwhether O\nJose B-PER\nMaria I-PER\nOlazabal I-PER\nshould O\nbe O\nallowed O\nto O\nreturn O\nto O\nthe O\nEuropean B-MISC\nPGA I-MISC\nTour I-MISC\nusing O\na O\nmotorised O\ncart O\nto O\ntransport O\nhim O\naround O\nthe O\ncourse O\n. O\n\nThe O\nSpaniard B-MISC\nhas O\nnot O\nplayed O\nfor O\nnearly O\na O\nyear O\nbecause O\nof O\nrheumatoid O\narthritis O\nin O\nboth O\nhis O\nfeet O\n, O\nand O\norganisers O\nof O\na O\npairs O\nevent O\nto O\nbe O\nstaged O\nin O\nBordeaux B-LOC\n, O\nFrance B-LOC\nfrom O\nOctober O\n17 O\nto O\n20 O\nhave O\nbeen O\nasked O\nto O\nprovide O\nhim O\nwith O\na O\nbuggy O\n. O\n\n\" O\nIf O\nthe O\n( O\nTour B-MISC\n's O\ntournament O\n) O\ncommittee O\ndecides O\nto O\nchange O\nthe O\nrule O\nI O\nwould O\nnot O\nbe O\nagainst O\nit O\n, O\n\" O\nsaid O\nBallesteros B-PER\n, O\nOlazabal B-PER\n's O\ncompatriot O\nand O\nRyder B-MISC\nCup I-MISC\ncaptain O\n. O\n\nBut O\ncommitee O\nmember O\nMontgomerie B-PER\nsaid O\nit O\ncould O\nset O\nan O\nunhelpful O\nprecedent O\n. O\n\" O\n\nI O\nknow O\nOlly B-PER\n's O\nsituation O\nis O\nvery O\nunfortunate O\n, O\nbut O\nI O\ndo O\nn't O\nthink O\nwe O\ncan O\nstart O\ngiving O\ndispensations O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nYou O\n've O\ngot O\nto O\nhave O\na O\nrule O\nfor O\neverybody O\nand O\nI O\ndo O\nn't O\nthink O\nit O\n's O\nfeasible O\n. O\n\" O\n\nThe O\nuse O\nof O\ncarts O\nis O\ngenerally O\nprohibited O\nin O\nthe O\nprofessional O\ngame O\n, O\nand O\nif O\nOlazabal B-PER\nis O\nallowed O\nto O\nuse O\none O\nin O\nBordeaux B-LOC\n, O\nhe O\nmight O\nthen O\nrequest O\none O\nfor O\nthe O\nqualifying O\ntournaments O\nfor O\nnext O\nyear O\n's O\nRyder B-MISC\nCup I-MISC\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPOLAND B-LOC\nTIES O\nCYPRUS B-LOC\n2-2 O\nIN O\nFRIENDLY O\nMATCH O\n. O\n\nBELCHATOW B-LOC\n, O\nPoland B-LOC\n1996-08-27 O\n\nPoland B-LOC\nand O\nCyprus B-LOC\ndrew O\n\n2-2 O\n( O\nhalftime O\n0-0 O\n) O\nin O\na O\nfriendly O\nsoccer O\ninternational O\non O\n\nTuesday O\n. O\n\nScorers O\n: O\n\nPoland B-LOC\n- O\nKrzysztof B-PER\nWarzycha I-PER\n( O\n46th O\nminute O\n) O\n, O\nMarcin B-PER\nMieciel I-PER\n\n( O\n57th O\n) O\n\nCyprus B-LOC\n- O\nKlimis B-PER\nAlexandrou I-PER\n( O\n75th O\n) O\n, O\nKostas B-PER\nMalekos I-PER\n( O\n80th O\n) O\n\nAttendance O\n3,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nTHOMSON B-PER\nRESIGNS O\nAS O\nMANAGER O\nOF O\nRAITH B-ORG\nROVERS I-ORG\n. O\n\nKIRKCALDY B-LOC\n, O\nScotland B-LOC\n1996-08-27 O\n\nJimmy B-PER\nThomson I-PER\nbecame O\nScotland B-LOC\n's O\nfirst O\nmanagerial O\ncasualty O\nof O\nthe O\nseason O\non O\nTuesday O\nwhen O\nhe O\nquit O\nRaith B-ORG\nRovers I-ORG\n, O\nbottom O\nof O\nthe O\npremier O\ndivision O\n. O\n\nThomson B-PER\nresigned O\nafter O\nthe O\nclub O\n's O\ndirectors O\nasked O\nhim O\nto O\nreturn O\nto O\nhis O\nprevious O\nposition O\nas O\nyouth O\nteam O\ncoach O\n. O\n\nHe O\nhad O\nbeen O\nin O\ncharge O\nfor O\nsix O\nmonths O\n. O\n\nRaith B-ORG\nlost O\ntheir O\nfirst O\ntwo O\ngames O\nof O\nthe O\nseason O\naway O\nto O\nRangers B-ORG\nand O\nCeltic B-ORG\n, O\nthen O\ncrashed O\n3-0 O\nat O\nhome O\nto O\nMotherwell B-ORG\non O\nSaturday O\n. O\n\nA O\nclub O\nstatement O\nsaid O\n: O\n\" O\nThe O\ndirectors O\nof O\nRaith B-ORG\nRovers I-ORG\nFC I-ORG\ninvited O\nJimmy B-PER\nThomson I-PER\nto O\nrelinquish O\nthe O\npost O\nof O\nmanager O\nand O\nto O\nresume O\nhis O\nformer O\nposition O\nas O\nyouth O\nteam O\ncoach O\n. O\n\n\" O\nRegrettably O\nJimmy B-PER\nhas O\nfelt O\nunable O\nto O\naccept O\nthat O\noffer O\n, O\nand O\nhas O\naccordingly O\nleft O\nthe O\nclub O\n. O\n\" O\n\nThomson B-PER\nsaid O\n: O\n\" O\nI O\nam O\nleaving O\nwith O\nmy O\ndignity O\nand O\nmy O\npride O\nintact O\n, O\nand O\nthat O\nis O\nvery O\nimportant O\nto O\nme O\n. O\n\n\" O\nWhile O\nnot O\nagreeing O\nwith O\nthe O\ndirectors O\n' O\ndecision O\n, O\nI O\nrespect O\ntheir O\nreasons O\nfor O\nmaking O\nit O\n. O\n\" O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nGRIQUALAND B-LOC\nWEST I-LOC\nAND O\nNEW B-LOC\nZEALAND I-LOC\nDRAW O\nIN O\nTOUR B-MISC\nMATCH O\n. O\n\nKIMBERLEY B-LOC\n, O\nSouth B-LOC\nAfrica I-LOC\n1996-08-27 O\n\nGriqualand B-LOC\nWest I-LOC\n\nand O\nNew B-LOC\nZealand I-LOC\ndrew O\n18-18 O\n( O\nhalftime O\n6-10 O\n) O\nin O\ntheir O\nrugby O\nunion O\n\ntour O\nmaltch O\non O\nTuesday O\n. O\n\nScorers O\n: O\n\nGriqualand B-LOC\nWest I-LOC\n- O\nTries O\n: O\nAndre B-PER\nCloete I-PER\n, O\nLeon B-PER\nvan I-PER\nder I-PER\nWath I-PER\n. O\n\nConversion O\n: O\nBoeta B-PER\nWessels I-PER\n. O\n\nPenalties O\n: O\nWessels B-PER\n2 O\n. O\n\nNew B-LOC\nZealand I-LOC\n- O\nTries O\n: O\nScott B-PER\nMcLeod I-PER\n, O\nGlen B-PER\nOsborne I-PER\n. O\n\nConversion O\n: O\n\nJon B-PER\nPreston I-PER\n. O\n\nPenalties O\n: O\nPreston B-PER\n2 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBALL B-PER\nRESIGNS O\nAS O\nMANCHESTER B-ORG\nCITY I-ORG\nMANAGER O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-27 O\n\nFormer O\nEngland B-LOC\nmidfielder O\nAlan B-PER\nBall I-PER\nresigned O\nas O\nmanager O\nof O\nfirst O\ndivision O\nside O\nManchester B-ORG\nCity I-ORG\non O\nMonday O\nnight O\n, O\nthe O\nclub O\nsaid O\n. O\n\nBall B-PER\n, O\nappointed O\nin O\nJuly O\n1995 O\n, O\nwas O\nunable O\nto O\nprevent O\nCity B-ORG\nbeing O\nrelegated O\nfrom O\nthe O\npremier O\nleague O\nlast O\nseason O\nand O\nhis O\nrecord O\nread O\n13 O\nwins O\n, O\n14 O\ndraws O\nand O\n22 O\nlosses O\nin O\n49 O\ngames O\n. O\n\nThey O\nhave O\nlost O\ntwo O\nof O\ntheir O\nthree O\nmatches O\nso O\nfar O\nthis O\nseason O\n. O\n\nClub O\nsecretary O\nBernard B-PER\nHalford I-PER\nsaid O\nin O\na O\nstatement O\n: O\n\" O\nThe O\nchairman O\nand O\nBoard B-ORG\nwould O\nlike O\nto O\nplace O\non O\nrecord O\ntheir O\nappreciation O\nof O\nhis O\nendeavours O\nand O\nefforts O\nwhilst O\nin O\nhis O\nperiod O\nof O\noffice O\nand O\nwish O\nhim O\nwell O\nin O\nthe O\nfuture O\n. O\n\" O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nLEAGUE O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-27 O\n\nEnglish B-MISC\nleague O\nsoccer O\nstandings O\n\nafter O\nTuesday O\n's O\nmatches O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\n\nlost O\n, O\ngoals O\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nDivision O\none O\n\nTranmere B-ORG\n3 O\n2 O\n1 O\n0 O\n6 O\n3 O\n7 O\n\nBolton B-ORG\n3 O\n2 O\n1 O\n0 O\n5 O\n2 O\n7 O\n\nBarnsley B-ORG\n2 O\n2 O\n0 O\n0 O\n5 O\n2 O\n6 O\n\nWolverhampton B-ORG\n2 O\n2 O\n0 O\n0 O\n4 O\n1 O\n6 O\n\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\n2 O\n2 O\n0 O\n0 O\n4 O\n2 O\n6 O\n\nStoke B-ORG\n2 O\n2 O\n0 O\n0 O\n4 O\n2 O\n6 O\n\nNorwich B-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n3 O\n6 O\n\nIpswich B-ORG\n3 O\n1 O\n1 O\n1 O\n6 O\n4 O\n4 O\n\nBirmingham B-ORG\n2 O\n1 O\n1 O\n0 O\n5 O\n4 O\n4 O\n\nCrystal B-ORG\nPalace I-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n2 O\n4 O\n\nOxford B-ORG\n3 O\n1 O\n0 O\n2 O\n6 O\n3 O\n3 O\n\nBradford B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n2 O\n3 O\n\nHuddersfield B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n3 O\n3 O\n\nPortsmouth B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n5 O\n3 O\n\nReading B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n5 O\n3 O\n\nManchester B-ORG\nCity I-ORG\n3 O\n1 O\n0 O\n2 O\n2 O\n3 O\n3 O\n\nWest B-ORG\nBromwich I-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n3 O\n2 O\n\nPort B-ORG\nVale I-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n4 O\n2 O\n\nSheffield B-ORG\nUnited I-ORG\n2 O\n0 O\n1 O\n1 O\n4 O\n5 O\n1 O\n\nGrimsby B-ORG\n3 O\n0 O\n1 O\n2 O\n4 O\n7 O\n1 O\n\nCharlton B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n3 O\n1 O\n\nSwindon B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n3 O\n1 O\n\nSouthend B-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n7 O\n1 O\n\nOldham B-ORG\n2 O\n0 O\n0 O\n2 O\n2 O\n5 O\n0 O\n\nDivisionn O\ntwo O\n\nPlymouth B-ORG\n3 O\n2 O\n1 O\n0 O\n8 O\n5 O\n7 O\n\nBrentford B-ORG\n3 O\n2 O\n1 O\n0 O\n6 O\n3 O\n7 O\n\nShrewsbury B-ORG\n3 O\n2 O\n1 O\n0 O\n6 O\n3 O\n7 O\n\nBury B-ORG\n3 O\n2 O\n1 O\n0 O\n4 O\n2 O\n7 O\n\nBurnley B-ORG\n3 O\n2 O\n0 O\n1 O\n5 O\n5 O\n6 O\n\nBournemouth B-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n3 O\n6 O\n\nBlackpool B-ORG\n3 O\n2 O\n0 O\n1 O\n3 O\n2 O\n6 O\n\nChesterfield B-ORG\n3 O\n2 O\n0 O\n1 O\n3 O\n2 O\n6 O\n\nMillwall B-ORG\n3 O\n1 O\n1 O\n1 O\n5 O\n4 O\n4 O\n\nCrewe B-ORG\n3 O\n1 O\n1 O\n1 O\n4 O\n4 O\n4 O\n\nGillingham B-ORG\n3 O\n1 O\n1 O\n1 O\n4 O\n5 O\n4 O\n\nPreston B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n3 O\n4 O\n\nNotts B-ORG\nCounty I-ORG\n2 O\n1 O\n1 O\n0 O\n2 O\n1 O\n4 O\n\nBristol B-ORG\nRovers I-ORG\n2 O\n1 O\n1 O\n0 O\n1 O\n0 O\n4 O\n\nBristol B-ORG\nCity I-ORG\n3 O\n1 O\n0 O\n2 O\n7 O\n4 O\n3 O\n\nYork B-ORG\n3 O\n1 O\n0 O\n2 O\n5 O\n6 O\n3 O\n\nWatford B-ORG\n3 O\n1 O\n0 O\n2 O\n2 O\n5 O\n3 O\n\nWrexham B-ORG\n2 O\n0 O\n2 O\n0 O\n5 O\n5 O\n2 O\n\nWycombe B-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n3 O\n2 O\n\nRotherham B-ORG\n3 O\n0 O\n1 O\n2 O\n3 O\n5 O\n1 O\n\nPeterborough B-ORG\n2 O\n0 O\n1 O\n1 O\n2 O\n3 O\n1 O\n\nWalsall B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n4 O\n1 O\n\nStockport B-ORG\n3 O\n0 O\n1 O\n2 O\n0 O\n2 O\n1 O\n\nLuton B-ORG\n3 O\n0 O\n0 O\n3 O\n3 O\n10 O\n0 O\n\nDivision O\nthree O\n\nHartlepool B-ORG\n3 O\n2 O\n1 O\n0 O\n6 O\n3 O\n7 O\n\nWigan B-ORG\n3 O\n2 O\n1 O\n0 O\n5 O\n2 O\n7 O\n\nHull B-ORG\n3 O\n2 O\n1 O\n0 O\n4 O\n2 O\n7 O\n\nCarlisle B-ORG\n3 O\n2 O\n1 O\n0 O\n2 O\n0 O\n7 O\n\nFulham B-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n3 O\n6 O\n\nScunthorpe B-ORG\n3 O\n2 O\n0 O\n1 O\n2 O\n2 O\n6 O\n\nScarborough B-ORG\n3 O\n1 O\n2 O\n0 O\n4 O\n2 O\n5 O\n\nExeter B-ORG\n3 O\n1 O\n2 O\n0 O\n4 O\n3 O\n5 O\n\nCambridge B-ORG\n3 O\n1 O\n2 O\n0 O\n3 O\n2 O\n5 O\n\nDarlington B-ORG\n3 O\n1 O\n1 O\n1 O\n7 O\n5 O\n4 O\n\nNorthampton B-ORG\n3 O\n1 O\n1 O\n1 O\n5 O\n3 O\n4 O\n\nBarnet B-ORG\n3 O\n1 O\n1 O\n1 O\n4 O\n2 O\n4 O\n\nChester B-ORG\n3 O\n1 O\n1 O\n1 O\n4 O\n3 O\n4 O\n\nTorquay B-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n3 O\n4 O\n\nCardiff B-ORG\n3 O\n1 O\n1 O\n1 O\n1 O\n2 O\n4 O\n\nSwansea B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n7 O\n3 O\n\nBrighton B-ORG\n3 O\n1 O\n0 O\n2 O\n2 O\n5 O\n3 O\n\nHereford B-ORG\n3 O\n1 O\n0 O\n2 O\n1 O\n2 O\n3 O\n\nLincoln B-ORG\n3 O\n0 O\n2 O\n1 O\n3 O\n4 O\n2 O\n\nColchester B-ORG\n3 O\n0 O\n2 O\n1 O\n1 O\n3 O\n2 O\n\nRochdale B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n4 O\n1 O\n\nMansfield B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n6 O\n1 O\n\nDoncaster B-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n3 O\n1 O\n\nLeyton B-ORG\nOrient I-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n3 O\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nLEAGUE O\nRESULTS O\n. O\n\nLONDON B-LOC\n1996-08-27 O\n\nResults O\nof O\nEnglish B-MISC\nleague O\nsoccer O\n\nmatches O\non O\nTuesday O\n: O\n\nDivision O\none O\n\nCrystal B-ORG\nPalace I-ORG\n0 O\nWest B-ORG\nBromwich I-ORG\n0 O\n\nIpswich B-ORG\n1 O\nGrimsby B-ORG\n1 O\n\nOxford B-ORG\n0 O\nNorwich B-ORG\n1 O\n\nPortsmouth B-ORG\n1 O\nSouthend B-ORG\n0 O\n\nTranmere B-ORG\n2 O\nPort B-ORG\nVale I-ORG\n0 O\n\nPostponed O\n: O\nCharlton B-ORG\nv O\nBirmingham B-ORG\n, O\nSheffield B-ORG\nUnited I-ORG\nv O\n\nHuddersfield B-ORG\n\nDivision O\ntwo O\n\nBrentford B-ORG\n2 O\nGillingham B-ORG\n0 O\n\nBristol B-ORG\nCity I-ORG\n5 O\nLuton B-ORG\n0 O\n\nBurnley B-ORG\n1 O\nShrewsbury B-ORG\n3 O\n\nChesterfield B-ORG\n1 O\nWalsall B-ORG\n0 O\n\nPreston B-ORG\n2 O\nCrewe B-ORG\n1 O\n\nRotherham B-ORG\n1 O\nBlackpool B-ORG\n2 O\n\nStockport B-ORG\n0 O\nBournemouth B-ORG\n1 O\n\nWatford B-ORG\n0 O\nPlymouth B-ORG\n2 O\n\nWycombe B-ORG\n0 O\nBury B-ORG\n1 O\n\nYork B-ORG\n3 O\nMillwall B-ORG\n2 O\n\nPostponed O\n: O\nPeterborough B-ORG\nv O\nNotts B-ORG\nCounty I-ORG\n, O\nWrexham B-ORG\nv O\nBristol B-ORG\n\nRovers B-ORG\n\nDivision O\nthree O\n\nBarnet B-ORG\n3 O\nBrighton B-ORG\n0 O\n\nCardiff B-ORG\n0 O\nWigan B-ORG\n2 O\n\nCarlisle B-ORG\n1 O\nLeyton B-ORG\nOrient I-ORG\n0 O\n\nChester B-ORG\n2 O\nSwansea B-ORG\n0 O\n\nDarlington B-ORG\n1 O\nColchester B-ORG\n1 O\n\nExeter B-ORG\n1 O\nDoncaster B-ORG\n1 O\n\nHartlepool B-ORG\n2 O\nMansfield B-ORG\n2 O\n\nHereford B-ORG\n0 O\nHull B-ORG\n1 O\n\nLincoln B-ORG\n1 O\nCambridge B-ORG\n1 O\n\nNorthampton B-ORG\n1 O\nTorquay B-ORG\n1 O\n\nRochdale B-ORG\n1 O\nFulham B-ORG\n2 O\n\nScunthorpe B-ORG\n0 O\nScarborough B-ORG\n2 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nAND O\nPAKISTAN B-LOC\nTEST O\nAVERAGES O\n. O\n\nLONDON B-LOC\n1996-08-27 O\n\nEngland B-LOC\nand O\nPakistan B-LOC\nTest O\naverages O\n\nafter O\ntheir O\nthree-match O\nseries O\nwhich O\nended O\non O\nMonday O\n: O\n\nEngland B-LOC\n\nBatting O\n( O\ntabulated O\nunder O\nmatches O\n, O\ninnings O\n, O\nnot O\nouts O\n, O\nruns O\n, O\n\nhighest O\nscore O\n, O\naverage O\n) O\n: O\n\nAlec B-PER\nStewart I-PER\n3 O\n5 O\n0 O\n396 O\n170 O\n79.20 O\n\nJohn B-PER\nCrawley I-PER\n2 O\n3 O\n0 O\n178 O\n106 O\n59.33 O\n\nNick B-PER\nKnight I-PER\n3 O\n5 O\n0 O\n190 O\n113 O\n38.00 O\n\nNasser B-PER\nHussain I-PER\n2 O\n3 O\n0 O\n111 O\n51 O\n37.00 O\n\nMike B-PER\nAtherton I-PER\n3 O\n5 O\n0 O\n162 O\n64 O\n32.40 O\n\nGraham B-PER\nThorpe I-PER\n3 O\n5 O\n0 O\n159 O\n77 O\n31.80 O\n\nJack B-PER\nRussell I-PER\n2 O\n3 O\n1 O\n51 O\n41no O\n25.50 O\n\nIan B-PER\nSalisbury I-PER\n2 O\n4 O\n1 O\n50 O\n40 O\n16.66 O\n\nMark B-PER\nEalham I-PER\n1 O\n2 O\n0 O\n30 O\n25 O\n15.00 O\n\nDominic B-PER\nCork I-PER\n3 O\n5 O\n0 O\n58 O\n26 O\n11.60 O\n\nRobert B-PER\nCroft I-PER\n1 O\n2 O\n1 O\n11 O\n6 O\n11.00 O\n\nSimon B-PER\nBrown I-PER\n1 O\n2 O\n1 O\n11 O\n10no O\n11.00 O\n\nAlan B-PER\nMullally I-PER\n3 O\n5 O\n1 O\n39 O\n24 O\n9.75 O\n\nChris B-PER\nLewis I-PER\n2 O\n3 O\n0 O\n18 O\n9 O\n6.00 O\n\nAndy B-PER\nCaddick I-PER\n1 O\n1 O\n0 O\n4 O\n4 O\n4.00 O\n\nGraeme B-PER\nHick I-PER\n1 O\n2 O\n0 O\n8 O\n4 O\n4.00 O\n\nBowling O\n( O\ntabulated O\nunder O\novers O\n, O\nmaidens O\n, O\nruns O\n, O\nwickets O\n, O\n\naverage O\n) O\n: O\n\nAtherton B-PER\n7 O\n1 O\n20 O\n1 O\n20.00 O\n\nCaddick B-PER\n57.2 O\n10 O\n165 O\n6 O\n27.50 O\n\nCork B-PER\n131 O\n23 O\n434 O\n12 O\n36.16 O\n\nMullally B-PER\n150.3 O\n36 O\n377 O\n10 O\n37.70 O\n\nHick B-PER\n13 O\n2 O\n42 O\n1 O\n42.00 O\n\nCroft B-PER\n47.4 O\n10 O\n125 O\n2 O\n62.50 O\n\nBrown B-PER\n33 O\n4 O\n138 O\n2 O\n69.00 O\n\nEalham B-PER\n37 O\n8 O\n81 O\n1 O\n81.00 O\n\nSalisbury B-PER\n61.2 O\n8 O\n221 O\n2 O\n110.50 O\n\nLewis B-PER\n71 O\n10 O\n264 O\n1 O\n264.00 O\n\nThorpe B-PER\n13 O\n4 O\n19 O\n0 O\n- O\n\nPakistan B-LOC\n\nBatting O\n: O\n\nMoin B-PER\nKhan I-PER\n2 O\n3 O\n1 O\n158 O\n105 O\n79.00 O\n\nIjaz B-PER\nAhmed I-PER\n3 O\n6 O\n1 O\n344 O\n141 O\n68.80 O\n\nSalim B-PER\nMalik I-PER\n3 O\n5 O\n2 O\n195 O\n100no O\n65.00 O\n\nInzamam-ul-Haq B-PER\n3 O\n5 O\n0 O\n320 O\n148 O\n64.00 O\n\nSaeed B-PER\nAnwar I-PER\n3 O\n6 O\n0 O\n362 O\n176 O\n60.33 O\n\nRashid B-PER\nLatif I-PER\n1 O\n1 O\n0 O\n45 O\n45 O\n45.00 O\n\nAamir B-PER\nSohail I-PER\n2 O\n3 O\n1 O\n77 O\n46 O\n38.50 O\n\nAsif B-PER\nMujtaba I-PER\n2 O\n3 O\n0 O\n90 O\n51 O\n30.00 O\n\nWasim B-PER\nAkram I-PER\n3 O\n5 O\n1 O\n98 O\n40 O\n24.50 O\n\nShadab B-PER\nKabir I-PER\n2 O\n4 O\n0 O\n87 O\n35 O\n21.75 O\n\nMushtaq B-PER\nAhmed I-PER\n3 O\n5 O\n1 O\n44 O\n20 O\n11.00 O\n\nWaqar B-PER\nYounis I-PER\n3 O\n3 O\n1 O\n11 O\n7 O\n5.50 O\n\nAta-ur-Rehman B-PER\n2 O\n2 O\n2 O\n10 O\n10no O\n- O\n\nMohammad B-PER\nAkram I-PER\n1 O\n0 O\n0 O\n0 O\n0 O\n- O\n\nBowling O\n: O\n\nMushtaq B-PER\nAhmed I-PER\n195 O\n52 O\n447 O\n17 O\n26.29 O\n\nWaqar B-PER\nYounis I-PER\n125 O\n25 O\n431 O\n16 O\n26.93 O\n\nWasim B-PER\nAkram I-PER\n128 O\n29 O\n350 O\n11 O\n31.81 O\n\nAta-ur-Rehman B-PER\n48.4 O\n6 O\n173 O\n5 O\n34.60 O\n\nMohammad B-PER\nAkram I-PER\n22 O\n4 O\n71 O\n1 O\n71.00 O\n\nAamir B-PER\nSohail I-PER\n11 O\n3 O\n24 O\n0 O\n- O\n\nAsif B-PER\nMujtaba I-PER\n7 O\n5 O\n6 O\n0 O\n- O\n\nSalim B-PER\nMalik I-PER\n1 O\n0 O\n1 O\n0 O\n- O\n\nShadab B-PER\nKabir I-PER\n1 O\n0 O\n9 O\n0 O\n- O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nGOOCH B-PER\nTO O\nPLAY O\nANOTHER O\nSEASON O\nFOR O\nESSEX B-LOC\n. O\n\nLONDON B-LOC\n1996-08-27 O\n\nGraham B-PER\nGooch I-PER\n, O\nthe O\n43-year-old O\nformer O\nEngland B-LOC\ncaptain O\n, O\nis O\nto O\ncontinue O\nplaying O\ncounty O\ncricket O\nfor O\nat O\nleast O\nanother O\nseason O\n, O\nhis O\nclub O\nEssex B-ORG\nannounced O\non O\nTuesday O\n. O\n\nOpener O\nGooch B-PER\n's O\ndecision O\ncomes O\ntowards O\nthe O\nend O\nof O\na O\nseason O\nin O\nwhich O\nhe O\nhas O\nunderlined O\nhis O\nconsistency O\nby O\nbecoming O\nthe O\nleading O\nscorer O\nin O\nEssex B-ORG\n's O\nhistory O\n, O\nbeating O\nKeith B-PER\nFletcher I-PER\n's O\naggregate O\nof O\n29,434 O\n. O\n\nGooch B-PER\n, O\nwho O\nretired O\nfrom O\ntest O\ncricket O\nafter O\nthe O\n1994-95 O\ntour O\nof O\nAustralia B-LOC\nbut O\nis O\nnow O\nan O\nEngland B-LOC\nselector O\n, O\nis O\nseventh O\nin O\nthis O\nseason O\n's O\nfirst-class O\naverages O\nwith O\n1,429 O\nruns O\nat O\n64.95 O\n, O\nhaving O\nhit O\nfive O\ncenturies O\nand O\none O\ndouble O\ncentury O\n. O\n\nEssex B-ORG\nsecretary-general O\nmanager O\nPeter B-PER\nEdwards I-PER\nsaid O\n: O\n\" O\nHe O\nis O\na O\nremarkable O\nbatsman O\nand O\nstill O\nthe O\nbest O\nin O\nthis O\ncountry O\n. O\n\nNo-one O\nwill O\nargue O\nwith O\nthat O\n. O\n\nYou O\njust O\nhave O\nto O\nlook O\nat O\nhis O\nrecord O\nto O\nappreciate O\nthat O\nfact O\n. O\n\" O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nROMANIA B-LOC\nCLUB O\nBOSS O\nBANNED O\nFOR O\nHEADBUTT O\n. O\n\nBUCHAREST B-LOC\n1996-08-27 O\n\nThe O\nRomanian B-ORG\nSoccer I-ORG\nFederation I-ORG\nhas O\nbanned O\nfirst O\ndivision O\nclub O\nJiul B-ORG\nPetrosani I-ORG\n's O\npresident O\nMiron B-PER\nCozma I-PER\nfor O\ntwo O\nyears O\nfor O\nheadbutting O\na O\nvisiting O\nteam O\nplayer O\n, O\na O\nfederation O\nstatement O\nsaid O\n. O\n\nRomania B-LOC\n's O\nsoccer O\nbosses O\nalso O\nfined O\nCozma B-PER\n, O\na O\nwell-known O\nminers O\n' O\nunion O\nleader O\n, O\n10 O\nmillion O\nlei O\n( O\n$ O\n3000 O\n) O\nfor O\nthe O\nhalf-time O\nattack O\non O\nDinamo B-ORG\nBucharest I-ORG\n's O\nDanut B-PER\nLupu I-PER\nlast O\nSunday O\n. O\n\nMiners O\nled O\nby O\nCozma B-PER\nrioted O\nin O\nBucharest B-LOC\nin O\n1990 O\nand O\n1991 O\n, O\nbringing O\ndown O\nthe O\nreformist O\ngovernment O\nof O\npremier O\nPetre B-PER\nRoman I-PER\n. O\n\nCozma B-PER\nis O\nawaiting O\ntrial O\nfor O\nassault O\nand O\ncriminal O\ndamage O\nin O\na O\nbar O\nin O\nhis O\nhome O\ntown O\nof O\nPetrosan B-LOC\n, O\n300 O\nkms O\nwest O\nof O\nBucharest B-LOC\n. O\n\nThe O\nattack O\non O\nLupu B-PER\ncame O\nduring O\na O\ntunnel O\nskirmish O\nbetween O\nopposing O\nplayers O\nas O\nthey O\nleft O\nthe O\nfield O\n. O\n\n\" O\nCozma B-PER\n's O\nblow O\nwas O\nnot O\ntoo O\npainful O\nbecause O\nI O\n'm O\na O\ntall O\nman O\n, O\n\" O\nLupu B-PER\ntold O\nReuters B-ORG\non O\nTuesday O\n. O\n\nLupu B-PER\nis O\none O\nof O\nthe O\ntallest O\nplayers O\nin O\nRomania B-LOC\n's O\nfirst O\ndivision O\n, O\ntowering O\nover O\nCozma B-PER\nby O\nsome O\n17 O\ncms O\n, O\n\nJiul B-ORG\nPetrosani I-ORG\n, O\npromoted O\nto O\nthe O\nfirst O\ndivision O\nthis O\nyear O\n, O\nwon O\nthe O\nleague O\ngame O\n1-0 O\n. O\n\nCozma B-PER\nis O\nbarred O\nfrom O\ntaking O\npart O\nin O\nany O\nofficial O\nsoccer O\nactivity O\nduring O\nthe O\nban O\n. O\n\n-DOCSTART- O\n\nSQUASH O\n- O\nHONG B-MISC\nKONG I-MISC\nOPEN I-MISC\nFIRST O\nROUND O\nRESULTS O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-27 O\n\nFirst O\nround O\nresults O\nin O\nthe O\nHong B-MISC\n\nKong B-MISC\nOpen I-MISC\nsquash O\ntournament O\non O\nTuesday O\n( O\nprefix O\ndenotes O\nseeding O\n) O\n: O\n\n1 O\n- O\nJansher B-PER\nKhan I-PER\n( O\nPakistnn O\n) O\nbeat O\nJackie B-PER\nLee I-PER\n( O\nHong B-LOC\nKong I-LOC\n) O\n15-8 O\n15-8 O\n\n15-6 O\n\n3 O\n- O\nBrett B-PER\nMartin I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nDavid B-PER\nEvans I-PER\n( O\nWales B-LOC\n) O\n14-17 O\n15-1 O\n\n13-15 O\n17-14 O\n15-12 O\n\nMark B-PER\nCairns I-PER\n( O\nEngland B-LOC\n) O\nbeat O\n6 O\n- O\nDel B-PER\nHarris I-PER\n( O\nEngland B-LOC\n) O\n15-12 O\n7-15 O\n\n15-6 O\n15-12 O\n\nAnthony B-PER\nHill I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\n8 O\n- O\nMark B-PER\nChaloner I-PER\n( O\nEngland B-LOC\n) O\n15-11 O\n\n17-16 O\n17-16 O\n\nSimon B-PER\nFrenz I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nMartin B-PER\nHeath I-PER\n( O\nScotland B-LOC\n) O\n12-15 O\n15-6 O\n\n15-4 O\n12-15 O\n15-14 O\n\nJoseph B-PER\nKneipp I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nAhmed B-PER\nFaizy I-PER\n( O\nEgypt B-LOC\n) O\n15-8 O\n12-15 O\n\n15-14 O\n15-9 O\n\nMir B-PER\nZaman I-PER\nGul I-PER\n( O\nPakistan B-LOC\n) O\nbeat O\nStephen B-PER\nMeads I-PER\n( O\nEngland B-LOC\n) O\n10-15 O\n\n15-12 O\n15-10 O\n15-3 O\n\nDan B-PER\nJensen I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nAnders B-PER\nThoren I-PER\n( O\nSweden B-LOC\n) O\n8-15 O\n15-12 O\n\n10-15 O\n15-5 O\n15-11 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nEDBERG B-PER\nEXTENDS O\nGRAND O\nSLAM O\nRUN O\n, O\nTOPPLES O\nWIMBLEDON B-LOC\nCHAMP O\n. O\n\nLarry B-PER\nFine I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-27 O\n\nStefan B-PER\nEdberg I-PER\nproduced O\nsome O\nof O\nhis O\nvintage O\nbest O\non O\nTuesday O\nto O\nextend O\nhis O\ngrand O\nrun O\nat O\nthe O\nGrand B-MISC\nSlams I-MISC\nby O\ntoppling O\nWimbledon B-MISC\nchampion O\nRichard B-PER\nKrajicek I-PER\nin O\nstraight O\nsets O\nat O\nthe O\nU.S. B-MISC\nOpen I-MISC\n. O\n\nEdberg B-PER\n, O\ncompeting O\nin O\nthe O\n54th O\nconsecutive O\nand O\nfinal O\nGrand B-MISC\nSlam I-MISC\nevent O\nof O\nhis O\nillustrious O\ncareer O\n, O\nturned O\nback O\nthe O\nclock O\nat O\nStadium B-LOC\nCourt I-LOC\nwith O\na O\nflowing O\n6-3 O\n6-3 O\n6-3 O\nserve-and-volley O\nvictory O\nover O\nthe O\nfifth-seeded O\nDutchman B-MISC\n. O\n\n\" O\nIt O\n's O\na O\nwin O\nthat O\nI O\ncan O\nbe O\nproud O\nof O\n, O\n\" O\nsaid O\nthe O\n30-year-old O\nSwede B-MISC\n, O\nwinner O\nof O\ntwo O\nU.S. B-LOC\nOpens O\nand O\nsix O\nGrand B-MISC\nSlam I-MISC\ntitles O\nin O\nall O\n. O\n\" O\n\nIt O\n's O\nnever O\neasy O\nto O\nbeat O\nthe O\nWimbledon B-MISC\nchampion O\n. O\n\" O\n\nEdberg B-PER\n, O\nwho O\nhas O\nsaid O\nhe O\nwill O\nretire O\nat O\nseason O\n's O\nend O\n, O\nmade O\nit O\nlook O\neasy O\nunder O\ngray O\nskies O\nat O\nthe O\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\n. O\n\nThe O\nunseeded O\nSwede B-MISC\nstruck O\nquickly O\n, O\nbreaking O\nKrajicek B-PER\nin O\nthe O\nfirst O\ngame O\nand O\nnever O\nlet O\nloose O\nhis O\ngrip O\non O\nthe O\none O\nhour O\n44 O\nminute O\nmatch O\nas O\nhe O\nserved O\nand O\nvolleyed O\nwith O\nthe O\ngrace O\nthat O\nmade O\nhim O\none O\nof O\nthe O\ndominant O\nplayers O\nof O\nhis O\ntime O\n. O\n\n\" O\nThere O\n's O\nnot O\ndoubt O\nabout O\nit O\n, O\nRichard B-PER\nwas O\ndefinitely O\noff O\nhis O\ngame O\nand O\nI O\ntook O\nadvantage O\n, O\n\" O\nsaid O\nEdberg B-PER\n. O\n\n\" O\nI O\nstill O\nhave O\nmy O\ndays O\nwhere O\nI O\nfeel O\ngreat O\nout O\nthere O\n. O\n\" O\n\nAlso O\nreaching O\nthe O\nsecond O\nround O\nwere O\ntop-seeded O\ndefending O\nchampion O\nPete B-PER\nSampras I-PER\n, O\na O\n6-2 O\n6-2 O\n6-1 O\nwinner O\nover O\nlast O\nminute O\nreplacement O\nJimy B-PER\nSzymanski I-PER\nof O\nVenezuela B-LOC\n, O\ncalled O\non O\nafter O\nAdrian B-PER\nVoinea I-PER\nof O\nRomania B-LOC\nwithdrew O\nbecause O\nof O\na O\nsprained O\nankle O\n. O\n\nThird O\nseed O\nThomas B-PER\nMuster I-PER\nof O\nAustria B-LOC\nalso O\ncharged O\ninto O\nthe O\nsecond O\nround O\nwith O\na O\n6-1 O\n7-6 O\n( O\n7-2 O\n) O\n6-2 O\nromp O\nover O\nJavier B-PER\nFrana I-PER\nof O\nArgentina B-LOC\n. O\n\nMarcelo B-PER\nRios I-PER\nof O\nChile B-LOC\n, O\nthe O\n10th O\nseed O\n, O\nalso O\nadvanced O\n. O\n\nRios B-PER\nclaimed O\na O\n4-6 O\n6-1 O\n6-4 O\n6-2 O\nvictory O\nover O\nRomania B-LOC\n's O\nAndrei B-PER\nPavel I-PER\n. O\n\nOn O\nthe O\nwomen O\n's O\nside O\n, O\nsecond O\nseed O\nMonica B-PER\nSeles I-PER\ngot O\noff O\nto O\na O\nstrong O\nstart O\nby O\nbeating O\nfellow-American O\nAnne B-PER\nMiller I-PER\n6-0 O\n6-1 O\nand O\nwas O\njoined O\nin O\nthe O\nsecond O\nround O\nby O\nSpain B-LOC\n's O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\n( O\nseeded O\nthird O\n) O\n, O\nOlympic B-MISC\nchampion O\nLindsay B-PER\nDavenport I-PER\n( O\n8 O\n) O\nand O\nKarina B-PER\nHabsudova I-PER\nof O\nSlovakia B-LOC\n( O\n17 O\n) O\n. O\n\nThe O\nwomen O\n's O\ndraw O\nlost O\nanother O\nseed O\nwhen O\nAustrian B-MISC\nJudith B-PER\nWiesner I-PER\novercame O\nIva B-PER\nMajoli I-PER\nof O\nCroatia B-LOC\n2-6 O\n6-3 O\n6-1 O\n. O\n\nThe O\nfifth- O\nseeded O\nMajoli B-PER\njoined O\nAnke B-PER\nHuber I-PER\n( O\n5 O\n) O\nand O\nMagdalena B-PER\nMaleeva I-PER\n( O\n12 O\n) O\non O\nthe O\nsidelines O\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nTUESDAY O\n'S O\nRESULTS O\nFROM O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-27 O\n\nResults O\nof O\nfirst O\nround O\nmatches O\non O\nTuesday O\nin O\nthe O\nU.S. B-MISC\nOpen I-MISC\ntennis O\nchampionships O\nat O\nthe O\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\n( O\nprefix O\ndenotes O\nseeding O\n) O\n: O\n\nWomen O\n's O\nsingles O\n\n2 O\n- O\nMonica B-PER\nSeles I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAnne B-PER\nMiller I-PER\n( O\nU.S. B-LOC\n) O\n6-0 O\n6-1 O\n\nRita B-PER\nGrande I-PER\n( O\nItaly B-LOC\n) O\nbeat O\nAlexia B-PER\nDechaume-Balleret I-PER\n( O\nFrance B-LOC\n) O\n6-3 O\n6-0 O\n\nJudith B-PER\nWiesner I-PER\n( O\nAustria B-LOC\n) O\nbeat O\n5 O\n- O\nIva B-PER\nMajoli I-PER\n( O\nCroatia B-LOC\n) O\n2-6 O\n6-3 O\n6- O\n1 O\n\nMen O\n's O\nsingles O\n\n3 O\n- O\nThomas B-PER\nMuster I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nJavier B-PER\nFrana I-PER\n( O\nArgentina B-LOC\n) O\n6-1 O\n7-6 O\n( O\n7-2 O\n) O\n6-2 O\n\nMen O\n's O\nsingles O\n\n1 O\n- O\nPete B-PER\nSampras I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nJimy B-PER\nSzymanski I-PER\n( O\nVenezuela B-LOC\n) O\n6-2 O\n6-2 O\n6 O\n- O\n1 O\n\nJiri B-PER\nNovak I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nBen B-PER\nEllwood I-PER\n( O\nAustralia B-LOC\n) O\n6-2 O\n6- O\n4 O\n6-3 O\n\nWomen O\n's O\nsingles O\n\nMariaan B-PER\nde I-PER\nSwardt I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\nDominique B-PER\nVan I-PER\nRoost I-PER\n( O\nBelgium B-LOC\n) O\n1-6 O\n6-2 O\n7-6 O\n( O\n7-4 O\n) O\n\nFlorencia B-PER\nLabat I-PER\n( O\nArgentina B-LOC\n) O\nbeat O\nKathy B-PER\nRinaldi I-PER\nStunkel I-PER\n( O\nU.S. B-LOC\n) O\n6 O\n- O\n2 O\n6-2 O\n\nNathalie B-PER\nTauziat I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nAngelica B-PER\nGavaldon I-PER\n( O\nMexico B-LOC\n) O\n7-6 O\n( O\n7-4 O\n) O\n6-2 O\n\nPaola B-PER\nSuarez I-PER\n( O\nArgentina B-LOC\n) O\nbeat O\nMarianne B-PER\nWerdel I-PER\nWitmeyer I-PER\n( O\nU.S. B-LOC\n) O\n6 O\n- O\n4 O\n6-3 O\n\nAnn B-PER\nGrossman I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nSilvia B-PER\nFarina I-PER\n( O\nItaly B-LOC\n) O\n6-4 O\n6-3 O\n\nMen O\n's O\nsingles O\n\nAlex B-PER\nCorretja I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nByron B-PER\nBlack I-PER\n( O\nZimbabwe B-LOC\n) O\n7-6 O\n( O\n8-6 O\n) O\n3-6 O\n6-2 O\n6-2 O\n\nScott B-PER\nDraper I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nGalo B-PER\nBlanco I-PER\n( O\nSpain B-LOC\n) O\n6-3 O\n7-5 O\n6-3 O\n\nPetr B-PER\nKorda I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nDavid B-PER\nCaldwell I-PER\n( O\nU.S. B-LOC\n) O\n6-3 O\n3-6 O\n6-3 O\n7-5 O\n\nBohdan B-PER\nUlihrach I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\n14 O\n- O\nAlberto B-PER\nCosta I-PER\n( O\nSpain B-LOC\n) O\n2-6 O\n6-4 O\n7-6 O\n( O\n7-2 O\n) O\n3-6 O\n6-1 O\n\nBernd B-PER\nKarbacher I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nJonathan B-PER\nStark I-PER\n( O\nU.S. B-LOC\n) O\n7-5 O\n6-3 O\n5- O\n7 O\n7-5 O\n\nWomen O\n's O\nsingles O\n\n8 O\n- O\nLindsay B-PER\nDavenport I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAdriana B-PER\nSerra-Zanetti I-PER\n( O\nItaly B-LOC\n) O\n6 O\n- O\n2 O\n6-1 O\n\nElena B-PER\nWagner I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nGigi B-PER\nFernandez I-PER\n( O\nU.S. B-LOC\n) O\n6-1 O\n6-4 O\n\nKristie B-PER\nBoogert I-PER\n( O\nNetherlands B-LOC\n) O\nbeat O\nJoannette B-PER\nKruger I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n6-1 O\n6-0 O\n\nMen O\n's O\nsingles O\n\nStefan B-PER\nEdberg I-PER\n( O\nSweden B-LOC\n) O\nbeat O\n5 O\n- O\nRichard B-PER\nKrajicek I-PER\n( O\nNetherlands B-LOC\n) O\n6- O\n3 O\n6-3 O\n6-3 O\n\n10 O\n- O\nMarcelo B-PER\nRios I-PER\n( O\nChile B-LOC\n) O\nbeat O\nAndrei B-PER\nPavel I-PER\n( O\nRomania B-LOC\n) O\n4-6 O\n6-1 O\n6-4 O\n6-2 O\n\nWomen O\n's O\nsingles O\n\n3 O\n- O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nLaxmi B-PER\nPoruri I-PER\n( O\nU.S. B-LOC\n) O\n6-2 O\n6-1 O\n\nMen O\n's O\nsingles O\n\nAndrei B-PER\nOlhovskiy I-PER\n( O\nRussia B-LOC\n) O\nbeat O\nPat B-PER\nCash I-PER\n( O\nAustralia B-LOC\n) O\n6-4 O\n6-3 O\n6-2 O\n\nFilippo B-PER\nVeglio I-PER\n( O\nSwitzerland B-LOC\n) O\nbeat O\nChristian B-PER\nRuud I-PER\n( O\nNorway B-LOC\n) O\n1-6 O\n6 O\n\n- O\n2 O\n6-4 O\n6-4 O\n\nTim B-PER\nHenman I-PER\n( O\nBritain B-LOC\n) O\nbeat O\nRoberto B-PER\nJabali I-PER\n( O\nBrazil B-LOC\n) O\n6-2 O\n6-3 O\n6-4 O\n\nPablo B-PER\nCampana I-PER\n( O\nEcuador B-LOC\n) O\nbeat O\nTodd B-PER\nWoodbridge I-PER\n( O\nAustralia B-LOC\n) O\n6-2 O\n4- O\n\n6 O\n6-2 O\n6-4 O\n\nHerman B-PER\nGumy I-PER\n( O\nArgentina B-LOC\n) O\nbeat O\nMartin B-PER\nDamm I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n7-5 O\n6 O\n\n- O\n4 O\n7-5 O\n\nJacob B-PER\nHlasek I-PER\n( O\nSwitzerland B-LOC\n) O\nbeat O\nNicklas B-PER\nKulti I-PER\n( O\nSweden B-LOC\n) O\n6-3 O\n6-4 O\n\n4-6 O\n6-4 O\n\nWomen O\n's O\nsingles O\n\n17- O\nKarina B-PER\nHabsudova I-PER\n( O\nSlovakia B-LOC\n) O\nbeat O\nRadka B-PER\nBobkova I-PER\n( O\nCzech B-LOC\n\nRepublic B-LOC\n) O\n6-4 O\n6-1 O\n\nKarin B-PER\nKschwendt I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nSandra B-PER\n\nKleinova B-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n6-3 O\n6-4 O\n\nAnnabel B-PER\nEllwood I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nJennifer B-PER\nCapriati I-PER\n( O\nU.S. B-LOC\n) O\n6-4 O\n6 O\n\n- O\n4 O\n\nNicole B-PER\nArendt I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nSandra B-PER\nCacic I-PER\n( O\nU.S. B-LOC\n) O\n6-2 O\n7-6 O\n( O\n8-6 O\n) O\n\nElena B-PER\nLikhovtseva I-PER\n( O\nRussia B-LOC\n) O\nbeat O\nKyoko B-PER\nNagatsuka I-PER\n( O\nJapan B-LOC\n) O\n7-6 O\n( O\n7- O\n\n5 O\n) O\n6-1 O\n\nSandrine B-PER\nTestud I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nPam B-PER\nShriver I-PER\n( O\nU.S. B-LOC\n) O\n7-5 O\n6-2 O\n\nWomen O\n's O\nsingles O\n\nKimberly B-PER\nPo I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\n10 O\n- O\nKimiko B-PER\nDate I-PER\n( O\nJapan B-LOC\n) O\n6-2 O\n7-5 O\n\nNatasha B-PER\nZvereva I-PER\n( O\nBelarus B-LOC\n) O\nbeat O\nVirginia B-PER\nRuano-Pascual I-PER\n( O\nSpain B-LOC\n) O\n6 O\n\n- O\n2 O\n6-7 O\n( O\n5-7 O\n) O\n6-2 O\nTina B-PER\nKirzan I-PER\n( O\nSlovakia B-LOC\n) O\nbeat O\nRika B-PER\nHiraki I-PER\n( O\nJapan B-LOC\n) O\n\n7-6 O\n( O\n7-4 O\n) O\n7-5 O\n\nPetra B-PER\nLangrova I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nKarina B-PER\nAdams I-PER\n( O\nU.S. B-LOC\n) O\n6-4 O\n6-2 O\n\nTami B-PER\nWhitlinger I-PER\nJones I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nSandra B-PER\nCecchini I-PER\n( O\nItaly B-LOC\n) O\n6-2 O\n6-0 O\n\n7 O\n- O\nJana B-PER\nNovotna I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nFrancesca B-PER\nLubiani I-PER\n( O\nItaly B-LOC\n) O\n\n6-1 O\n7-5 O\n\nMen O\n's O\nsingles O\n\n13 O\n- O\nThomas B-PER\nEnqvist I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nStephane B-PER\nSimian I-PER\n( O\nFrance B-LOC\n) O\n6-3 O\n6-1 O\n6-4 O\n\nMen O\n's O\nsingles O\n\nMikael B-PER\nTillstrom I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nTamer B-PER\nEl I-PER\nSawy I-PER\n( O\nEgypt B-LOC\n) O\n1-6 O\n7-6 O\n( O\n9 O\n\n- O\n7 O\n) O\n6-1 O\n3-6 O\n6-4 O\n\nRoberto B-PER\nCarretero I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nJordi B-PER\nBurillo I-PER\n( O\nSpain B-LOC\n) O\n6-3 O\n4-6 O\n6- O\n\n0 O\n1-0 O\nRetired O\n( O\nankle O\ninjury O\n) O\n\nThomas B-PER\nJohansson I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nRenzo B-PER\nFurlan I-PER\n( O\nItaly B-LOC\n) O\n4-6 O\n2-6 O\n7-5 O\n\n6-1 O\n7-5 O\n\nMark B-PER\nKnowles I-PER\n( O\nBahamas B-LOC\n) O\nbeat O\nMarcelo B-PER\nFilippini I-PER\n( O\nUruguay B-LOC\n) O\n6-3 O\n7-5 O\n\n6-1 O\n\nJared B-PER\nPalmer I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\n15 O\n- O\nMarc B-PER\nRosset I-PER\n( O\nSwitzerland B-LOC\n) O\n6-7 O\n( O\n7-9 O\n) O\n\n6-4 O\n6-4 O\n6-3 O\n\nWomen O\n's O\nsingles O\n\nAmy B-PER\nFrazier I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nLarisa B-PER\nNeiland I-PER\n( O\nLatvia B-LOC\n) O\n6-1 O\n6-3 O\n\nWomen O\n's O\nsingles O\n\nLisa B-PER\nRaymond I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nLori B-PER\nMcNeil I-PER\n( O\nU.S. B-LOC\n) O\n7-6 O\n( O\n8-6 O\n) O\n6-3 O\n\nSandra B-PER\nDopfer I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nZina B-PER\nGarrison I-PER\nJackson I-PER\n( O\nU.S. B-LOC\n) O\n2-6 O\n6-3 O\n7-5 O\n\n4 O\n- O\nConchita B-PER\nMartinez I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nRuxandra B-PER\nDragomir I-PER\n( O\nRomania B-LOC\n) O\n6-2 O\n6-0 O\n\nNaoko B-PER\nSawamatsu I-PER\n( O\nJapan B-LOC\n) O\nbeat O\nRennae B-PER\nStubbs I-PER\n( O\nAustralia B-LOC\n) O\n6-4 O\n6-3 O\n\nMiriam B-PER\nOremans I-PER\n( O\nNetherlands B-LOC\n) O\nbeat O\nRadka B-PER\nZrubakova I-PER\n( O\nSlovakia B-LOC\n) O\n6-2 O\n4-6 O\n6-1 O\n\nMen O\n's O\nsingles O\n\nDoug B-PER\nFlach I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nGianluca B-PER\nPozzi I-PER\n( O\nItaly B-LOC\n) O\n7-5 O\n7-6 O\n( O\n7-5 O\n) O\n2-6 O\n7-6 O\n( O\n8-6 O\n) O\n\n16 O\n- O\nCedric B-PER\nPioline I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nFrancisco B-PER\nClavet I-PER\n( O\nSpain B-LOC\n) O\n6-4 O\n7-6 O\n( O\n7-3 O\n) O\n6-4 O\n\nJavier B-PER\nSanchez I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nDavid B-PER\nSkoch I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n6-2 O\n7-6 O\n( O\n7-0 O\n) O\n6-3 O\n\nWomen O\n's O\nsingles O\n, O\nfirst O\nround O\n1 O\n- O\nSteffi B-PER\nGraf I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nYayuk B-PER\nBasuki I-PER\n( O\nIndonesia B-LOC\n) O\n6-3 O\n7-6 O\n( O\n7-4 O\n) O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nMONDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-27 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nMonday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n74 O\n56 O\n.569 O\n- O\n\nBALTIMORE B-ORG\n69 O\n61 O\n.531 O\n5 O\n\nBOSTON B-ORG\n67 O\n65 O\n.508 O\n8 O\n\nTORONTO B-ORG\n62 O\n70 O\n.470 O\n13 O\n\nDETROIT B-ORG\n47 O\n84 O\n.359 O\n27 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n78 O\n53 O\n.595 O\n- O\n\nCHICAGO B-ORG\n70 O\n63 O\n.526 O\n9 O\n\nMINNESOTA B-ORG\n65 O\n66 O\n.496 O\n13 O\n\nMILWAUKEE B-ORG\n63 O\n69 O\n.477 O\n15 O\n1/2 O\n\nKANSAS B-ORG\nCITY I-ORG\n59 O\n73 O\n.447 O\n19 O\n1/2 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n75 O\n56 O\n.573 O\n- O\n\nSEATTLE B-ORG\n67 O\n63 O\n.515 O\n7 O\n1/2 O\n\nOAKLAND B-ORG\n63 O\n71 O\n.470 O\n13 O\n1/2 O\n\nCALIFORNIA B-ORG\n61 O\n70 O\n.466 O\n14 O\n\nTUESDAY O\n, O\nAUGUST O\n27TH O\nSCHEDULE O\n\nCLEVELAND B-ORG\nAT O\nDETROIT B-LOC\n\nOAKLAND B-ORG\nAT O\nBALTIMORE B-LOC\n\nMINNESOTA B-ORG\nAT O\nTORONTO B-LOC\n\nMILWAUKEE B-ORG\nAT O\nCHICAGO B-LOC\n\nTEXAS B-ORG\nAT O\nKANSAS B-LOC\nCITY I-LOC\n\nBOSTON B-ORG\nAT O\nCALIFORNIA B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nSEATTLE B-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n81 O\n48 O\n.628 O\n- O\n\nMONTREAL B-ORG\n70 O\n59 O\n.543 O\n11 O\n\nFLORIDA B-ORG\n61 O\n70 O\n.466 O\n21 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n72 O\n.450 O\n23 O\n\nPHILADELPHIA B-ORG\n53 O\n79 O\n.402 O\n29 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nHOUSTON B-ORG\n70 O\n62 O\n.530 O\n- O\n\nST B-ORG\nLOUIS I-ORG\n69 O\n62 O\n.527 O\n1/2 O\n\nCHICAGO B-ORG\n64 O\n64 O\n.500 O\n4 O\n\nCINCINNATI B-ORG\n64 O\n66 O\n.492 O\n5 O\n\nPITTSBURGH B-ORG\n55 O\n75 O\n.423 O\n14 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n72 O\n60 O\n.545 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n70 O\n60 O\n.538 O\n1 O\n\nCOLORADO B-ORG\n69 O\n63 O\n.523 O\n3 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n56 O\n73 O\n.434 O\n14 O\n1/2 O\n\nTUESDAY O\n, O\nAUGUST O\n27TH O\nSCHEDULE O\n\nPHILADELPHIA B-ORG\nAT O\nSAN B-LOC\nFRANCISCO I-LOC\n\nLOS B-ORG\nANGELES I-ORG\nAT O\nMONTREAL B-LOC\n\nATLANTA B-ORG\nAT O\nPITTSBURGH B-LOC\n\nSAN B-ORG\nDIEGO I-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nCHICAGO B-ORG\nAT O\nHOUSTON B-LOC\n\nFLORIDA B-ORG\nAT O\nST B-LOC\nLOUIS I-LOC\n\nCINCINNATI B-ORG\nAT O\nCOLORADO B-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nGIANTS B-ORG\nEDGE O\nPHILLIES B-ORG\n1-0 O\n. O\n\nSAN B-LOC\nFRANCISCO I-LOC\n1996-08-27 O\n\nWilliam B-PER\nVanLandingham I-PER\npitched O\neight O\nscoreless O\ninnings O\nand O\nGlenallen B-PER\nHill I-PER\ndrove O\nin O\nthe O\ngame O\n's O\nonly O\nrun O\nwith O\na O\nfirst-inning O\nsingle O\nas O\nthe O\nSan B-ORG\nFrancisco I-ORG\nGiants I-ORG\nclaimed O\na O\n1-0 O\nvictory O\nover O\nthe O\nPhiladelphia B-ORG\nPhillies I-ORG\non O\nMonday O\n. O\n\nVanLandingham B-PER\n( O\n8-13 O\n) O\n, O\nwho O\nentered O\nthe O\ngame O\nwith O\none O\ncomplete O\ngame O\nin O\nthe O\nfirst O\n56 O\nstarts O\nof O\nhis O\ncareer O\n, O\nlimited O\nthe O\nPhillies B-ORG\nto O\ntwo O\nhits O\nand O\ntwo O\nwalks O\nwith O\nfour O\nstrikeouts O\n. O\n\n\" O\nWe O\n've O\nbeen O\nworking O\nall O\nyear O\non O\nmy O\nfollow-through O\n, O\nand O\nI O\nreally O\nconcentrated O\non O\nthat O\n, O\n\" O\nVanLandingham B-PER\nsaid O\n. O\n\" O\n\nIt O\ngave O\nme O\nmore O\nlife O\nin O\nall O\nof O\nmy O\npitches O\n, O\nso O\nthe O\nball O\nmoved O\nmore O\n. O\n\" O\n\nAt O\nColorado B-LOC\n, O\nAndres B-PER\nGalarraga I-PER\nhomered O\nand O\ndrove O\nin O\nthree O\nruns O\nas O\nthe O\nColorado B-ORG\nRockies I-ORG\nhad O\n10 O\nextra-base O\nhits O\nand O\nBilly B-PER\nSwift I-PER\nwon O\nhis O\nfirst O\ngame O\nin O\nalmost O\na O\nyear O\nin O\na O\n9-5 O\nrain-shortened O\nseven-inning O\nvictory O\nover O\nthe O\nCincinnati B-ORG\nReds I-ORG\n. O\n\nSwift B-PER\n( O\n1-0 O\n) O\n, O\nwho O\nmade O\nhis O\nfirst O\nstart O\nsince O\nJune O\n3rd O\nand O\nunderwent O\narthroscopic O\nsurgery O\non O\nhis O\nright O\nshoulder O\nearlier O\nin O\nthe O\nseason O\n, O\nallowed O\nfive O\nruns O\nand O\nsix O\nhits O\nin O\nfive O\ninnings O\n. O\n\nIn O\nHouston B-LOC\n, O\nAndy B-PER\nBenes I-PER\nallowed O\ntwo O\nruns O\nover O\nseven O\ninnings O\nand O\nRoyce B-PER\nClayton I-PER\nhad O\na O\nrun-scoring O\nsingle O\nin O\nthe O\nseventh O\nto O\nlift O\nthe O\nSt. B-ORG\nLouis I-ORG\nCardinals I-ORG\nto O\na O\n3-2 O\nvictory O\nover O\nthe O\nHouston B-ORG\nAstros I-ORG\n. O\n\nBenes B-PER\n( O\n14-9 O\n) O\nallowed O\nfive O\nhits O\n, O\nwalked O\nfive O\nand O\nstruck O\nout O\n10 O\nfor O\nhis O\n11th O\nwin O\nin O\n12 O\ndecisions O\n. O\n\nThe O\nCardinals B-ORG\nmoved O\nwithin O\none-half O\ngame O\nof O\nfirst-place O\nHouston B-ORG\nin O\nthe O\nNational B-MISC\nLeague I-MISC\nCentral I-MISC\nDivision I-MISC\n. O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nORIOLES B-ORG\nWIN O\n, O\nYANKEES B-ORG\nLOSE O\n. O\n\nBALTIMORE B-LOC\n1996-08-27 O\n\nCal B-PER\nRipken I-PER\n's O\nbases-loaded O\nwalk O\nscored O\nBrady B-PER\nAnderson I-PER\nwith O\nthe O\nwinning O\nrun O\nin O\nthe O\nbottom O\nof O\nthe O\n10th O\nas O\nthe O\nBaltimore B-ORG\nOrioles I-ORG\nregained O\ncontrol O\nof O\nthe O\ntop O\nspot O\nin O\nthe O\nwild-card O\nrace O\nwith O\na O\nwild O\n12-11 O\nvictory O\nover O\nthe O\nOakland B-ORG\nAthletics I-ORG\n. O\n\nTrailing O\nby O\na O\nrun O\nentering O\nthe O\n11th O\n, O\nthe O\nOrioles B-ORG\nrallied O\nagainst O\nOakland B-ORG\nreliever O\nMark B-PER\nAcre I-PER\n( O\n0-2 O\n) O\nwith O\na O\nwalk O\nand O\na O\ntriple O\nby O\nBrady B-PER\nAnderson I-PER\nto O\ntie O\nthe O\ngame O\n. O\n\nThen O\nOakland B-ORG\nmanager O\nArt B-PER\nHowe I-PER\ndecided O\nto O\nintentionally O\nwalk O\nRafael B-PER\nPalmeiro I-PER\nand O\nBobby B-PER\nBonilla I-PER\nto O\nload O\nthe O\nbases O\nbut O\nAcre B-PER\nwas O\nnowhere O\nnear O\nthe O\nplate O\nto O\nRipken B-PER\n. O\n\nThe O\ndecisive O\npitch O\nnearly O\nhit O\nRipken B-PER\nand O\ngave O\nthe O\nOrioles B-ORG\na O\none-half O\ngame O\nlead O\nover O\nthe O\nChicago B-ORG\nWhite I-ORG\nSox I-ORG\nin O\nthe O\nwild-card O\nrace O\n. O\n\nIn O\nSeattle B-LOC\n, O\nJay B-PER\nBuhner I-PER\n's O\neighth-inning O\nsingle O\nsnapped O\na O\ntie O\nas O\nthe O\nSeattle B-ORG\nMariners I-ORG\nedged O\nthe O\nNew B-ORG\nYork I-ORG\nYankees I-ORG\n2-1 O\nin O\nthe O\nopener O\nof O\na O\nthree-game O\nseries O\n. O\n\nNew B-ORG\nYork I-ORG\nstarter O\nJimmy B-PER\nKey I-PER\nleft O\nthe O\ngame O\nin O\nthe O\nfirst O\ninning O\nafter O\nSeattle B-ORG\nshortstop O\nAlex B-PER\nRodriguez I-PER\nlined O\na O\nshot O\noff O\nhis O\nleft O\nelbow O\n. O\n\nThe O\nYankees B-ORG\nhave O\nlost O\n12 O\nof O\ntheir O\nlast O\n19 O\ngames O\nand O\ntheir O\nlead O\nin O\nthe O\nAL B-MISC\nEast B-MISC\nover O\nBaltimore B-ORG\nfell O\nto O\nfive O\ngames O\n. O\n\nAt O\nCalifornia B-LOC\n, O\nTim B-PER\nWakefield I-PER\npitched O\na O\nsix-hitter O\nfor O\nhis O\nthird O\ncomplete O\ngame O\nof O\nthe O\nseason O\nand O\nMo B-PER\nVaughn I-PER\nand O\nTroy B-PER\nO'Leary I-PER\nhit O\nsolo O\nhome O\nruns O\nin O\nthe O\nsecond O\ninning O\nas O\nthe O\nsurging O\nBoston B-ORG\nRed I-ORG\nSox I-ORG\nwon O\ntheir O\nthird O\nstraight O\n4-1 O\nover O\nthe O\nCalifornia B-ORG\nAngels I-ORG\n. O\n\nBoston B-ORG\nhas O\nwon O\nseven O\nof O\neight O\nand O\nis O\n20-6 O\nsince O\nAugust O\n2nd O\n. O\n\nThe O\nRed B-ORG\nSox I-ORG\nare O\ntwo O\ngames O\nover O\n.500 O\nfor O\nthe O\nfirst O\ntime O\nthis O\nseason O\n. O\n\nIn O\nChicago B-LOC\n, O\nCal B-PER\nEldred I-PER\npitched O\n5-1/3 O\nscoreless O\ninnings O\nand O\nJohn B-PER\nJaha I-PER\nscored O\none O\nrun O\nand O\ndoubled O\nin O\nanother O\nas O\nthe O\nMilwaukee B-ORG\nBrewers I-ORG\nheld O\noff O\nthe O\nslumping O\nChicago B-ORG\nWhite I-ORG\nSox I-ORG\n, O\n3-2 O\n. O\n\nEldred O\n( O\n6-5 O\n) O\nwalked O\none O\nand O\nstruck O\nout O\nthree O\n. O\n\nAngel B-PER\nMiranda I-PER\nretired O\none O\nbatter O\nand O\nBob B-PER\nWickman I-PER\nretired O\nthe O\nnext O\nfour O\nbut O\nloaded O\nthe O\nbases O\nin O\nthe O\neighth O\n. O\n\nIn O\nDetroit B-LOC\n, O\nJim B-PER\nThome I-PER\n's O\nsolo O\nhomer O\nin O\nthe O\nninth O\ninning O\nsnapped O\na O\ntie O\nand O\nCharles B-PER\nNagy I-PER\npitched O\na O\nthree-hitter O\nfor O\nhis O\nfirst O\nwin O\nin O\nover O\na O\nmonth O\n, O\nleading O\nthe O\nCleveland B-ORG\nIndians I-ORG\nto O\ntheir O\n11th O\nstraight O\nvictory O\nover O\nthe O\nDetroit B-ORG\nTigers I-ORG\n, O\n2-1 O\n. O\n\nWith O\nthe O\nscore O\ntied O\n1-1 O\nin O\nthe O\nninth O\n, O\nThome O\nhit O\na O\n2-2 O\npitch O\nfrom O\nstarter O\nFelipe B-PER\nLira I-PER\n( O\n6-11 O\n) O\nover O\nthe O\nleft-field O\nfence O\nfor O\nhis O\n29th O\nhomer O\n. O\n\nIn O\nToronto B-LOC\n, O\nJuan B-PER\nGuzman I-PER\nallowed O\nthree O\nruns O\nover O\nseven O\ninnings O\nto O\nmake O\nhomers O\nby O\nJoe B-PER\nCarter I-PER\nand O\nCarlos B-PER\nDelgado I-PER\nstand O\nup O\nas O\nthe O\nsurging O\nToronto B-ORG\nBlue I-ORG\nJays I-ORG\nheld O\noff O\nthe O\nMinnesota B-ORG\nTwins I-ORG\n, O\n5-3 O\n. O\n\nToronto B-LOC\nreturned O\nhome O\nfrom O\na O\n10-game O\nroad O\ntrip O\nand O\nwon O\nfor O\nthe O\neighth O\ntime O\nin O\nnine O\ngames O\nas O\nGuzman B-PER\n( O\n11-8 O\n) O\nallowed O\nnine O\nhits O\nand O\nstruck O\nout O\neight O\nwithout O\na O\nwalk O\n. O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nMONDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\ngames O\n\nplayed O\non O\nMonday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nAmerican B-MISC\nLeague I-MISC\n\nCleveland B-ORG\n2 O\nDETROIT B-ORG\n1 O\n\nBALTIMORE B-ORG\n12 O\nOakland B-ORG\n11 O\n( O\n10 O\ninnings O\n) O\n\nTORONTO B-ORG\n5 O\nMinnesota B-ORG\n3 O\n\nMilwaukee B-ORG\n3 O\nCHICAGO B-ORG\n2 O\n\nBoston B-ORG\n4 O\nCALIFORNIA B-ORG\n1 O\n\nSEATTLE B-ORG\n2 O\nNew B-ORG\nYork I-ORG\n1 O\n\nNational B-MISC\nLeague I-MISC\n\nSAN B-ORG\nFRANCISCO I-ORG\n1 O\nPhiladelphia B-ORG\n0 O\n\nSt B-ORG\nLouis I-ORG\n3 O\nHOUSTON B-ORG\n2 O\n\nCOLORADO B-ORG\n9 O\nCincinnati B-ORG\n5 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nCHANG B-PER\n, O\nWASHINGTON B-LOC\nADVANCE O\n, O\nTWO O\nWOMEN O\n'S O\nSEEDS O\nFALL O\n. O\n\nLarry B-PER\nFine I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-26 O\n\nMichael B-PER\nChang I-PER\nis O\nplaying O\nin O\nhis O\n10th O\nU.S. B-MISC\nOpen I-MISC\nand O\nenjoying O\nhis O\nhighest O\nseeding O\never O\n, O\nbut O\nthe O\n24-year-old O\nAmerican B-MISC\nhad O\nto O\novercome O\na O\ncase O\nof O\nthe O\njitters O\nMonday O\nbefore O\nwinning O\nhis O\nfirst-round O\nmatch O\non O\nopening O\nday O\n. O\n\nChang B-PER\n, O\nseeded O\nsecond O\nbehind O\ndefending O\nchampion O\nPete B-PER\nSampras I-PER\n, O\ntook O\ntwo O\nhours O\n40 O\nminutes O\nto O\ndefeat O\n186th-ranked O\nJaime B-PER\nOncins I-PER\nof O\nBrazil B-LOC\n3-6 O\n6-1 O\n6-0 O\n7-6 O\n, O\n8-6 O\nin O\nthe O\ntiebreaker O\n. O\n\n\" O\nI O\nwas O\npretty O\ntight O\nthe O\nwhole O\nmatch O\n, O\n\" O\nconceded O\nChang B-PER\n, O\none O\nof O\nthe O\nhottest O\nplayers O\non O\ntour O\nthis O\nsummer O\nwith O\na O\n16-2 O\nrecord O\non O\nhardcourts O\nthat O\nincluded O\ntwo O\ntitles O\nand O\na O\nrunner-up O\nfinish O\n. O\n\n\" O\nEveryone O\nhas O\nmoments O\nwhen O\nthey O\nget O\ntight O\n. O\n\nHopefully O\n, O\nthis O\nwill O\nhave O\nbeen O\nmy O\nnerves O\nfor O\nthe O\nwhole O\ntournament O\n. O\n\" O\n\nJoining O\nChang B-PER\ninto O\nthe O\nsecond O\nround O\nwas O\nWimbledon B-MISC\nrunner-up O\nMaliVai B-PER\nWashington I-PER\n, O\nthe O\n11th O\nseed O\n, O\nwho O\nalso O\nneeded O\nfour O\nsets O\nto O\nget O\npast O\ntalented O\nMoroccan B-MISC\nKarim B-PER\nAlami I-PER\n6-4 O\n2-6 O\n7-6 O\n( O\n7-5 O\n) O\n6-1 O\n. O\n\nWashington B-PER\n's O\nwin O\nwas O\nnot O\ncomfortable O\n, O\neither O\n. O\n\nThe O\n27-year-old O\nAmerican B-MISC\nhurried O\noff O\nthe O\nStadium B-LOC\nCourt I-LOC\nfor O\ntreatment O\nof O\nan O\nupset O\nstomach O\nafter O\nhis O\ntwo O\nand O\na O\nhalf O\nhour O\nstruggle O\nagainst O\nAlami B-PER\n. O\n\n\" O\nTowards O\nthe O\nend O\nof O\nmy O\nmatch O\nmy O\nstomach O\nfelt O\nlike O\nweek-old O\nsushi O\n, O\n\" O\nsaid O\nWashington B-LOC\n. O\n\" O\n\nMaybe O\nit O\nwas O\na O\ncombination O\nof O\nthe O\nheat O\nand O\nsomething O\nI O\nate O\n. O\n\" O\n\nChang B-PER\nand O\nWashington B-PER\nwere O\nthe O\nonly O\nmen O\n's O\nseeds O\nin O\naction O\non O\na O\nday O\nthat O\nsaw O\ntwo O\nseeded O\nwomen O\n's O\nplayers O\nfall O\n. O\n\nAustralian B-MISC\nOpen I-MISC\nrunner-up O\nAnke B-PER\nHuber I-PER\nof O\nGermany B-LOC\n, O\nthe O\nsixth O\nseed O\n, O\nwas O\nundone O\nby O\nan O\nunlucky O\ndraw O\nthat O\nput O\nher O\nagainst O\n17th O\nranked O\nSouth B-MISC\nAfrican I-MISC\nAmanda B-PER\nCoetzer I-PER\nin O\nher O\nopening O\nmatch O\n. O\n\nCoetzer B-PER\nclaimed O\nrevenge O\nfor O\nthe O\nsemifinal O\ndefeat O\nshe O\nsuffered O\nto O\nHuber B-PER\nin O\nMelbourne B-LOC\nby O\ntaking O\na O\n6-1 O\n2-6 O\n6-2 O\nvictory O\n. O\n\nLast O\nyear O\n's O\nWimbledon B-MISC\njunior O\nchampion O\n, O\nAleksandra B-PER\nOlsza I-PER\nof O\nPoland B-LOC\n, O\nremoved O\nanother O\nseed O\nfrom O\nthe O\ndraw O\nby O\neliminating O\nnumber O\n12 O\nMagdalena B-PER\nMaleeva I-PER\nof O\nBulgaria B-LOC\n6-4 O\n6-2 O\n. O\n\nOther O\nmen O\n's O\nwinners O\nincluded O\na O\npair O\nof O\nformer O\nGrand B-MISC\nSlam I-MISC\ntournament O\nchampions O\nwhose O\nvictories O\nset O\nup O\na O\nshowdown O\nin O\nthe O\nsecond O\nround O\n. O\n\nGermany B-LOC\n's O\nMichael B-PER\nStich I-PER\n, O\nthe O\n1991 O\nWimbledon B-MISC\nchampion O\n, O\nand O\ntwo-time O\nFrench B-MISC\nOpen I-MISC\nwinner O\nSergi B-PER\nBruguera I-PER\nof O\nSpain B-LOC\nwill O\nface O\neach O\nother O\nnext O\nafter O\nbeating O\nGerman B-MISC\nTommy B-PER\nHaas I-PER\n6-3 O\n1-6 O\n6-1 O\n7-5 O\n, O\nand O\nBelgian B-MISC\nKris B-PER\nGoossens I-PER\n6-2 O\n6-0 O\n7-6 O\n( O\n7-1 O\n) O\n, O\nrespectively O\n. O\n\nAlex B-PER\nO'Brien I-PER\n, O\nwho O\nscored O\nhis O\nfirst O\nprofessional O\ntitle O\neight O\ndays O\nago O\nin O\nNew B-LOC\nHaven I-LOC\n, O\nadvanced O\nto O\nthe O\nsecond O\nround O\nwith O\na O\n6-4 O\n1-6 O\n6-4 O\n6-3 O\nwin O\nover O\nEcuador B-LOC\n's O\nNicolas B-PER\nLapentti I-PER\n. O\n\nWimbledon B-MISC\nbad O\nboy O\nJeff B-PER\nTarango I-PER\ncaught O\na O\nbreak O\nMonday O\nwhen O\nhe O\nadvanced O\nafter O\nthe O\nretirement O\nof O\nGerman B-MISC\nAlex B-PER\nRadulescu I-PER\ndue O\nto O\nheat O\nexhaustion O\n. O\n\nTarango B-PER\nwas O\nleading O\n6-7 O\n( O\n5-7 O\n) O\n6-4 O\n6-1 O\n3-1 O\n. O\n\nChang B-PER\nblamed O\nbreezy O\nconditions O\nfor O\nsome O\nof O\nthe O\nerratic O\nplay O\nin O\nhis O\nmatch O\nwith O\nOncins B-PER\n, O\nwho O\nhad O\nbeaten O\nhim O\nin O\nthe O\nround O\nof O\n32 O\nat O\nthe O\n1992 O\nBarcelona B-LOC\nOlympics B-MISC\n. O\n\nChang B-PER\ncommitted O\nan O\nuntidy O\n53 O\nunforced O\nerrors O\n, O\nthough O\nhe O\nmade O\nseven O\nfewer O\nthan O\nthe O\nBrazilian B-MISC\n, O\nwho O\nalso O\nwalloped O\na O\nwoeful O\n24 O\ndouble O\nfaults O\n. O\n\nThe O\nmost O\ndeflating O\ndouble O\nfault O\ncame O\nwhen O\nOncins B-PER\nwas O\nserving O\nto O\nforce O\na O\nfifth O\nset O\n, O\nleading O\n6-4 O\nin O\nthe O\ntiebreaker O\n. O\n\nThe O\nset O\npoint O\ncame O\nafter O\nconfusion O\nat O\nthe O\nnet O\non O\nthe O\npoint O\nprevious O\n, O\nwhich O\nwas O\nawarded O\nto O\nOncins B-PER\nafter O\nthe O\ntwo O\nexchanged O\nshots O\nat O\nclose O\nquarters O\nat O\nthe O\nnet O\n. O\n\nFirst O\nChang B-PER\napproached O\nthe O\numpire O\n, O\nthen O\nOncins B-PER\n, O\nthen O\nChang B-PER\nagain O\nbefore O\nplay O\nfinally O\nresumed O\n. O\n\n\" O\nThose O\nlittle O\nseconds O\nwere O\nlike O\nan O\nhour O\nto O\nme O\n, O\n\" O\nsaid O\nOncins B-PER\n, O\nwho O\npromptly O\nfired O\ntwo O\nserves O\nbarely O\ncontained O\nby O\nthe O\nbaseline O\nas O\nhe O\nfrittered O\naway O\nhis O\nbest O\nchance O\n. O\n\nChang B-PER\nran O\noff O\nthe O\nnext O\nthree O\npoints O\nto O\nclose O\nout O\nthe O\nmatch O\nbut O\nfor O\nOncins B-PER\n, O\nthe O\ncontest O\nwas O\na O\npersonal O\nvictory O\n. O\n\nThe O\n26-year-old O\nBrazilian B-MISC\nhad O\nrisen O\ninto O\nthe O\ntop O\n30 O\nin O\n1992 O\n. O\n\nThe O\nnext O\nyear O\na O\nclose O\nfriend O\nwas O\nstruck O\nby O\na O\nstray O\nbullet O\nwhile O\nriding O\nhome O\nin O\na O\ncar O\nfrom O\na O\nsoccer O\ngame O\nin O\nSao B-LOC\nPaulo I-LOC\n. O\n\nHe O\ndied O\nslumped O\nagainst O\nOncins B-PER\n, O\nwho O\nsubsequently O\nlost O\ninterest O\nin O\ntennis O\n. O\n\n\" O\nTwo O\nmonths O\nago O\nI O\nstarted O\ntalking O\nabout O\nquitting O\n, O\n\" O\nsaid O\nOncins B-PER\n, O\nwho O\ndecided O\nto O\ngive O\nit O\none O\nlast O\ntry O\nand O\nmade O\nit O\nthrough O\nthe O\nOpen B-MISC\nqualifying O\ntournament O\nlast O\nweekend O\n. O\n\n\" O\nI O\nbelieve O\nin O\nmy O\ngame O\nagain O\n, O\n\" O\nhe O\nsaid O\n. O\n\nAt O\nthe O\nend O\nof O\nthe O\nday O\n, O\na O\nspate O\nof O\nwithdrawals O\nfrom O\nthe O\ntournament O\nwere O\nannounced O\n. O\n\nEighth O\nseed O\nJim B-PER\nCourier I-PER\nwithdrew O\nbecause O\nof O\na O\nbruised O\nright O\nknee O\n, O\nand O\n1988 O\nOpen B-MISC\nchampion O\nMats B-PER\nWilander I-PER\nbowed O\nout O\ndue O\nto O\na O\ngroin O\npull O\n, O\norganisers O\nsaid O\n. O\n\nWomen O\n's O\nninth O\nseed O\nMary B-PER\nJoe I-PER\nFernandez I-PER\npulled O\nout O\nbecause O\nof O\ntendinitis O\nin O\nher O\nright O\nwrist O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nFIRST O\nDIVISION O\nSUMMARY O\n. O\n\nPARIS B-LOC\n1996-08-27 O\n\nSummary O\nof O\na O\nFrench B-MISC\nfirst O\ndivision O\nsoccer O\nmatch O\non O\nTuesday O\n: O\n\nAuxerre B-ORG\n0 O\nMarseille B-ORG\n0 O\n. O\n\nAttendance O\n: O\n20,000 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nMARSEILLE B-ORG\nHOLD O\nAUXERRE B-ORG\nTO O\nGOALLESS O\nDRAW O\n. O\n\nPARIS B-LOC\n1996-08-27 O\n\nFormer O\nEuropean B-MISC\nchampions O\nMarseille B-ORG\nheld O\nFrench B-MISC\nchampions O\nAuxerre B-ORG\nto O\na O\ngoalless O\ndraw O\nin O\na O\nlacklustre O\nleague O\nmatch O\non O\nTuesday O\n. O\n\nThe O\nbill O\nlooked O\npromising O\nbut O\nboth O\nsides O\n, O\nstruggling O\nto O\nfind O\ntheir O\nform O\nearly O\nin O\nthe O\nseason O\n, O\nwere O\ndisappointing O\n. O\n\nAuxerre B-ORG\n, O\nwho O\nstart O\ntheir O\nEuropean B-MISC\nCup I-MISC\ncampaign O\nnext O\nweek O\nagainst O\nAjax B-ORG\nAmsterdam I-ORG\n, O\ndominated O\nthe O\nmatch O\nbut O\nwere O\nunable O\nto O\nscore O\n. O\n\nUnbeaten O\nin O\nfour O\nmatches O\n, O\nthey O\nstill O\ntrail O\nleaders O\nLens B-ORG\nby O\none O\npoint O\n. O\n\nLens B-ORG\n, O\nwho O\nhave O\nwon O\nall O\ntheir O\nthree O\nleague O\nmatches O\nso O\nfar O\n, O\nhost O\nMontpellier B-ORG\non O\nWednesday O\nnight O\n. O\n\nDespite O\nanother O\ndismal O\nperformance O\n, O\nespecially O\nin O\ndefence O\n, O\nMarseille B-ORG\nrestored O\nsome O\npride O\nby O\nkeeping O\nthe O\nreigning O\nchampions O\nat O\nbay O\nafter O\nlosing O\n2-1 O\nat O\nhome O\nto O\nMetz B-ORG\nlast O\nSaturday O\n. O\n\nAfter O\ntwo O\nseasons O\nin O\nthe O\nsecond O\ndivision O\nand O\nafter O\ntaking O\non O\nhalf O\na O\ndozen O\nnew O\nrecruits O\nthis O\nseason O\n, O\nsome O\nof O\nwhom O\ndo O\nnot O\nspeak O\na O\nword O\nof O\nFrench B-MISC\n, O\nMarseille B-ORG\nare O\nnot O\nplaying O\nwith O\nany O\nfluidity O\n. O\n\nBut O\nGerman B-MISC\ninternational O\ngoalkeeper O\nAndreas B-PER\nKoepke I-PER\nagain O\nproved O\na O\nsound O\ninvestment O\nwhen O\nunder O\npressure O\nfrom O\nthe O\nAuxerre B-ORG\nstrikers O\n, O\nsaving O\nhis O\nteam O\nwith O\na O\nnumber O\nof O\nfine O\nparries O\n. O\n\nMarseille B-ORG\nnow O\nlie O\nseventh O\nin O\nthe O\nleague O\non O\nfive O\npoints O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nFIRST O\nDIVISION O\nRESULT O\n. O\n\nPARIS B-LOC\n1996-08-27 O\n\nResult O\nof O\na O\nFrench B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatch O\nplayed O\non O\nTuesday O\n: O\n\nAuxerre B-ORG\n0 O\nMarseille B-ORG\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nSUMMARIES O\n. O\n\nBONN B-LOC\n1996-08-27 O\n\nSummaries O\nof O\nBundesliga B-MISC\nmatches O\n\nplayed O\non O\nTuesday O\n: O\n\nBorussia B-ORG\nDortmund I-ORG\n3 O\n( O\nRiedle B-PER\n8th O\nminute O\n, O\nHeinrich B-PER\n29th O\n, O\n\nTretschok B-PER\n77th O\n) O\nFreiburg B-ORG\n1 O\n( O\nDecheiver B-PER\n51st O\npenalty O\n) O\n. O\n\nHalftime O\n\n2-0 O\n. O\n\nAttendance O\n48,800 O\n. O\n\nHamburg B-ORG\n0 O\nVfB B-ORG\nStuttgart I-ORG\n4 O\n( O\nBalakov B-PER\n29th O\n, O\nBobic B-PER\n47th O\nand O\n60th O\n, O\n\nHagner B-PER\n85th O\n) O\n. O\n\n0-1 O\n. O\n\n31,139 O\n. O\n\nWerder B-ORG\nBremen I-ORG\n1 O\n( O\nSchulz B-PER\n31st O\n) O\nBorussia B-ORG\nMoenchengladbach I-ORG\n0 O\n. O\n\n1-0 O\n. O\n\n24,800 O\n. O\n\nSchalke B-ORG\n1 O\n( O\nThon B-PER\n2nd O\n) O\nBochum B-ORG\n1 O\n( O\nDonkow B-PER\n86th O\n) O\n. O\n\n1-0 O\n. O\n\n33,230 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n. O\n\nBONN B-LOC\n1996-08-27 O\n\nResults O\nof O\nBundesliga B-MISC\nmatches O\n\nplayed O\non O\nTuesday O\n: O\n\nBorussia B-ORG\nDortmund I-ORG\n3 O\nFreiburg B-ORG\n1 O\n\nHamburg B-ORG\n0 O\nVfB B-ORG\nStuttgart I-ORG\n4 O\n\nWerder B-ORG\nBremen I-ORG\n1 O\nBorussia B-ORG\nMoenchengladbach I-ORG\n0 O\n\nSchalke B-ORG\n1 O\nBochum B-ORG\n1 O\n\nBundesliga B-MISC\nstandings O\nafter O\nTuesday O\n's O\ngames O\n( O\ntabulate O\nunder O\n\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nVfB B-ORG\nStuttgart I-ORG\n3 O\n3 O\n0 O\n0 O\n10 O\n1 O\n9 O\n\nBorussia B-ORG\nDortmund I-ORG\n4 O\n3 O\n0 O\n1 O\n12 O\n6 O\n9 O\n\nCologne B-ORG\n3 O\n3 O\n0 O\n0 O\n7 O\n1 O\n9 O\n\nBayern B-ORG\nMunich I-ORG\n3 O\n2 O\n1 O\n0 O\n7 O\n2 O\n7 O\n\nBayer B-ORG\nLeverkusen I-ORG\n3 O\n2 O\n0 O\n1 O\n7 O\n4 O\n6 O\n\nVfL B-ORG\nBochum I-ORG\n4 O\n1 O\n3 O\n0 O\n4 O\n3 O\n6 O\n\nHamburg B-ORG\n4 O\n2 O\n0 O\n2 O\n7 O\n7 O\n6 O\n\nKarlsruhe B-ORG\n2 O\n1 O\n1 O\n0 O\n5 O\n3 O\n4 O\n\nSt B-ORG\nPauli I-ORG\n3 O\n1 O\n1 O\n1 O\n7 O\n7 O\n4 O\n\nWerder B-ORG\nBremen I-ORG\n4 O\n1 O\n1 O\n2 O\n5 O\n6 O\n4 O\n\n1860 B-ORG\nMunich I-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n5 O\n3 O\n\nSchalke B-ORG\n4 O\n0 O\n3 O\n1 O\n5 O\n9 O\n3 O\n\nFortuna B-ORG\nDuesseldorf I-ORG\n3 O\n1 O\n0 O\n2 O\n1 O\n7 O\n3 O\n\nFreiburg B-ORG\n4 O\n1 O\n0 O\n3 O\n6 O\n13 O\n3 O\n\nHansa B-ORG\nRostock I-ORG\n3 O\n0 O\n2 O\n1 O\n3 O\n4 O\n2 O\n\nArminia B-ORG\nBielefeld I-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n3 O\n2 O\n\nBorussia B-ORG\nMoenchengladbach I-ORG\n4 O\n0 O\n2 O\n2 O\n1 O\n4 O\n2 O\n\nMSV B-ORG\nDuisburg I-ORG\n3 O\n0 O\n0 O\n3 O\n1 O\n8 O\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nSUMMARY O\n. O\n\nAMSTERDAM B-LOC\n1996-08-27 O\n\nDutch B-MISC\nfirst O\ndivision O\nsummary O\non O\n\nTuesday O\n: O\n\nFortuna B-ORG\nSittard I-ORG\n2 O\n( O\nJeffrey B-PER\n7 O\n, O\nRoest B-PER\n33 O\n) O\nHeerenveen B-ORG\n4 O\n( O\nKorneev B-PER\n\n15 O\n, O\nHansma B-PER\n24 O\n, O\nWouden B-PER\n70 O\n, O\n90 O\n) O\n. O\n\nHalftime O\n2-2 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nRESULT O\n. O\n\nAMSTERDAM B-LOC\n1996-08-27 O\n\nResult O\nof O\na O\nDutch B-MISC\nfirst O\n\ndivision O\nsoccer O\nmatch O\nplayed O\non O\nTuesday O\n: O\n\nFortuna B-ORG\nSittard I-ORG\n2 O\nHeerenveen B-ORG\n4 O\n\n-DOCSTART- O\n\nICE O\nHOCKEY O\n- O\nFINLAND B-LOC\nBEAT O\nCZECH B-LOC\nREPUBLIC I-LOC\nIN O\nWORLD B-MISC\nCUP I-MISC\nMATCH O\n. O\n\nHELSINKI B-LOC\n1996-08-27 O\n\nFinland B-LOC\nbeat O\nthe O\nCzech B-LOC\nRepublic I-LOC\n\n7-3 O\n( O\nperiod O\nscores O\n4-1 O\n1-1 O\n2-1 O\n) O\nin O\ntheir O\nice O\nhockey O\nWorld B-MISC\nCup I-MISC\n, O\n\nEuropean B-MISC\ngroup O\nmatch O\non O\nTuesday O\n. O\n\nScorers O\n: O\n\nFinland B-LOC\n- O\nVille B-PER\nPeltonen I-PER\n( O\n10th O\nminute O\n) O\n, O\nJuha B-PER\nYlonen I-PER\n( O\n10th O\n) O\n, O\n\nTeemu B-PER\nSelanne I-PER\n( O\n11th O\n) O\n, O\nJyrki B-PER\nLumme I-PER\n( O\n13th O\nand O\n51st O\n) O\n, O\nJanne B-PER\nOjanen I-PER\n\n( O\n23rd O\n) O\n, O\nChristian B-PER\nRuuttu I-PER\n( O\n45th O\n) O\n\nCzech B-LOC\nRepublic I-LOC\n- O\nRadek B-PER\nBonk I-PER\n( O\n7th O\n) O\n, O\nRobert B-PER\nReichel I-PER\n( O\n33rd O\n, O\n\npenalty O\n) O\n, O\nJiri B-PER\nDopita I-PER\n( O\n57th O\n) O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nSweden B-LOC\n1 O\n1 O\n0 O\n0 O\n6 O\n1 O\n2 O\n\nFinland B-LOC\n1 O\n1 O\n0 O\n0 O\n7 O\n3 O\n2 O\n\nCzech B-LOC\nRepublic I-LOC\n1 O\n0 O\n0 O\n1 O\n3 O\n7 O\n0 O\n\nGermany B-LOC\n1 O\n0 O\n0 O\n1 O\n1 O\n6 O\n0 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nNEUCHATEL B-ORG\nTO O\nAPPEAL O\nAGAINST O\nCYPRIEN B-PER\n'S O\nNINE-MONTH O\nBAN O\n. O\n\nGENEVA B-LOC\n1996-08-27 O\n\nSwiss B-MISC\nleague O\nleaders O\nNeuchatel B-ORG\nXamax I-ORG\nsaid O\non O\nTuesday O\nthey O\nwould O\nappeal O\nagainst O\na O\nnine-month O\nban O\nimposed O\non O\nFrench B-MISC\ninternational O\ndefender O\nJean-Pierre B-PER\nCyprien I-PER\nfor O\nhis O\npart O\nin O\na O\npost-match O\nbrawl O\n. O\n\nCyprien B-PER\n, O\nalso O\nfined O\n10,000 O\nSwiss B-MISC\nfrancs O\n( O\n$ O\n8,400 O\n) O\n, O\ntraded O\npunches O\nwith O\nSt B-ORG\nGallen I-ORG\n's O\nBrazilian B-MISC\nplayer O\nClaudio B-PER\nMoura I-PER\nafter O\na O\nmatch O\non O\nSaturday O\n. O\n\nWhen O\nofficials O\nand O\ncoaching O\nstaff O\ntried O\nto O\nintervene O\n, O\nCyprien B-PER\nlaunched O\na O\nflying O\nkick O\nat O\nMoura B-PER\n, O\nbut O\nonly O\nsucceeded O\nin O\nkneeing O\nSt B-ORG\nGallen I-ORG\ncoach O\nRoger B-PER\nHegi I-PER\nin O\nthe O\nstomach O\n. O\n\nMoura B-PER\n, O\nwho O\nappeared O\nto O\nhave O\nelbowed O\nCyprien B-PER\nin O\nthe O\nfinal O\nminutes O\nof O\nthe O\n3-0 O\nwin O\nby O\nNeuchatel B-ORG\n, O\nwas O\nsuspended O\nfor O\nseven O\nmatches O\nand O\nfined O\n1,000 O\nfrancs O\n( O\n$ O\n840 O\n) O\nby O\nthe O\nSwiss B-MISC\nleague O\ndisciplinary O\ncommittee O\n. O\n\nClub O\npresident O\nGilbert B-PER\nFacchinetti I-PER\nsaid O\nhe O\nwas O\nastonished O\nthe O\ncommittee O\nhad O\narrived O\nat O\nits O\ndecision O\nso O\nquickly O\nand O\nvowed O\nthe O\nclub O\nwould O\nappeal O\n. O\n\nNeuchatel B-ORG\ncoach O\nGilbert B-PER\nGress I-PER\ndescribed O\nthe O\nincident O\nas O\n\" O\nshocking O\n\" O\n, O\nbut O\nsaid O\nMoura B-PER\nwas O\nalso O\nto O\nblame O\n. O\n\n\" O\nMoura B-PER\nphysically O\nand O\nverbally O\nprovoked O\nCyprien B-PER\nduring O\nthe O\nmatch O\n. O\n\nThe O\nreferee O\ncould O\nnot O\nhave O\nseen O\nit O\nor O\nhe O\nwould O\nhave O\npunished O\nhim O\n, O\n\" O\nGress B-PER\nsaid O\n. O\n\n\" O\nDuring O\nthe O\nscuffle O\n, O\nMoura B-PER\nthrew O\nthe O\nfirst O\npunch O\n. O\n\nTomorrow O\n, O\nif O\nsomeone O\npunches O\nme O\n, O\nI O\nwould O\nnot O\nknow O\nhow O\nto O\nreact O\n. O\n\" O\n\nCyprien B-PER\n, O\nwho O\nwon O\nhis O\none O\nFrench B-MISC\ncap O\nagainst O\nItaly B-LOC\nin O\nFebruary O\n1994 O\n, O\ncannot O\nplay O\nin O\nSwitzerland B-LOC\nor O\nelsewhere O\nuntil O\nMay O\nnext O\nyear O\n. O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nBUGNO B-PER\nCLEARED O\nOF O\nDOPING O\n. O\n\nMILAN B-LOC\n1996-08-27 O\n\nVeteran O\nItalian B-MISC\nGianni B-PER\nBugno I-PER\nhas O\nbeen O\ncleared O\nof O\ndoping O\nafter O\ntesting O\npositive O\nfor O\nhigh O\nlevels O\nof O\ntestosterone O\nduring O\nthe O\nTour B-MISC\nof I-MISC\nSwitzerland I-MISC\nin O\nJune O\n, O\nthe O\nItalian B-MISC\ncycling O\nfederation O\nsaid O\non O\nTuesday O\n. O\n\n\" O\nHe O\nhas O\nbeen O\ncleared O\n. O\n\nThe O\ncase O\nis O\nclosed O\n, O\n\" O\na O\nspokesman O\nsaid O\n. O\n\nBugno B-PER\ntested O\npositive O\nfor O\nthe O\nbanned O\nhormone O\nafter O\nthe O\nfifth O\nstage O\nof O\nthe O\nTour B-MISC\n, O\nin O\nwhich O\nhe O\nfinished O\nthird O\noverall O\n. O\n\nBut O\nthe O\nspokesman O\nsaid O\nsubsequent O\ntests O\nin O\nCologne B-LOC\nproved O\nhis O\nbody O\nproduced O\nhigher-than-average O\ntestosterone O\nlevels O\nnaturally O\n. O\n\nBugno B-PER\n, O\nwho O\nwon O\nthe O\nGiro B-MISC\nd'Italia I-MISC\nin O\n1990 O\nand O\ntwo O\nsuccessive O\nworld O\ntitles O\n, O\nwas O\nbanned O\nfor O\nthree O\nmonths O\nin O\n1994 O\nafter O\ntesting O\npositive O\nfor O\nthe O\nstimulant O\ncaffeine O\n. O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nCOLONNA B-PER\nWINS O\nFIRST O\nSTAGE O\nOF O\nTOUR B-MISC\nOF I-MISC\nNETHERLANDS I-MISC\n. O\n\nHAARLEM B-LOC\n, O\nNetherlands B-LOC\n1996-08-27 O\n\nLeading O\nresults O\nand O\noverall O\nstandings O\nafter O\nthe O\n161 O\nkilometre O\nfirst O\nstage O\nof O\nthe O\nTour B-MISC\nof I-MISC\nthe I-MISC\nNetherlands I-MISC\nbetween O\nGouda B-LOC\nand O\nHaarlem B-LOC\non O\nTuesday O\n. O\n\n1. O\nFederico B-PER\nColonna I-PER\n( O\nItaly B-LOC\n) O\nMapei B-ORG\nthree O\nhours O\n43 O\nmins O\nfive O\nsecs O\n\n2. O\nRobbie B-PER\nMcEwen I-PER\n( O\nAustralia B-LOC\n) O\nRabobank B-ORG\n\n3. O\nJans B-PER\nKoerts I-PER\n( O\nNetherlands B-LOC\n) O\nPalmans B-ORG\n\n4. O\nSven B-PER\nTeutenberg I-PER\n( O\nGermany B-LOC\n) O\nUS B-ORG\nPostal I-ORG\n\n5. O\nTom B-PER\nSteels I-PER\n( O\nBelgium B-LOC\n) O\nMapei B-ORG\n\n6. O\nEndrio B-PER\nLeoni I-PER\n( O\nItaly B-LOC\n) O\nAki B-PER\n\n7. O\nJohan B-PER\nCapiot I-PER\n( O\nBelgium B-LOC\n) O\nCollstrop B-ORG\n\n8. O\nJohn B-PER\nden I-PER\nBraber I-PER\n( O\nNeths B-LOC\n) O\nCollstrop B-ORG\n\n9. O\nJeroen B-PER\nBlijlevens I-PER\n( O\nNeths B-LOC\n) O\nTVM B-ORG\n\n10. O\nMichael B-PER\nvan I-PER\nder I-PER\nWolf I-PER\n( O\nNeths B-LOC\n) O\nForeldorado B-ORG\nall O\nsame O\ntime O\n. O\n\nLeading O\noverall O\nstandings O\nafter O\nfirst O\nstage O\n. O\n\n1. O\nColonna B-PER\nthree O\nhours O\n42 O\nmins O\n55 O\nseconds O\n\n2. O\nMcEwen B-PER\n0:04 O\nseconds O\nbehind O\n\n3. O\nKoerts B-PER\n0:06 O\n\n4. O\nGianluca B-PER\nCorini I-PER\n( O\nItaly B-LOC\n) O\nAki B-ORG\n0:07 O\n\n5. O\nWim B-PER\nOmloop I-PER\n( O\nBelgium B-LOC\n) O\nCollstrop B-ORG\nsame O\ntime O\n\n6. O\nLance B-PER\nArmstrong I-PER\n( O\nUSA B-LOC\n) O\nMotorola B-ORG\n0:08 O\n\n7. O\nTristan B-PER\nHoffman I-PER\n( O\nNeths B-LOC\n) O\nTVM B-ORG\nsame O\ntime O\n\n8. O\nGeorge B-PER\nHincapie I-PER\n( O\nUSA B-LOC\n) O\nMotorola B-ORG\n0:09 O\n\n9. O\nJohn B-PER\nTalen I-PER\n( O\nNeths B-LOC\n) O\nForeldorado B-ORG\nsame O\ntime O\n\n10. O\nTeutenberg B-PER\n0:10 O\n\n-DOCSTART- O\n\nCOFINEC B-ORG\nSLIPS O\nON O\nBUDAPEST B-LOC\nBOURSE O\nBUT O\nFUTURE O\nSTRONG O\n. O\n\nEmese B-PER\nBartha I-PER\n\nBUDAPEST B-LOC\n1996-08-27 O\n\nExpectations O\nthat O\nCofinec B-ORG\nS.A. I-ORG\n, O\nthe O\nHungarian B-MISC\nbourse O\n's O\nfirst O\nforeign O\nlisting O\n, O\nwill O\nreport O\na O\ndisappointing O\nfirst O\nhalf O\nhave O\ndepressed O\nthe O\nstock O\nbelow O\nits O\nissue O\nprice O\n, O\nbut O\nanalysts O\nexpect O\na O\nrebound O\nin O\nthe O\nlong O\nterm O\n. O\n\n\" O\nThe O\nfirst O\nhalf O\nof O\nthe O\nyear O\nis O\nunlikely O\nto O\nbe O\nas O\nstrong O\nas O\nexpected O\nso O\nthe O\ncompany O\nwill O\nprobably O\nbe O\nunable O\nto O\nreach O\nits O\nannual O\nplan O\nin O\n1996 O\n, O\n\" O\nsaid O\nGabor B-PER\nSitanyi I-PER\n, O\na O\nLondon-based O\nanalyst O\nfor O\nING B-ORG\nBarings I-ORG\n. O\n\nThe O\nFrench-registered B-MISC\npackaging O\nmaterials O\ncompany O\n, O\nwhich O\nfloated O\nits O\nshares O\nin O\nHungary B-LOC\nin O\nJuly O\n, O\nfor O\nmost O\nof O\nthe O\npast O\ntwo O\nweeks O\nhovered O\nbelow O\nthe O\n6,425 O\nforints O\n/ O\nGlobal O\nDepositary O\nReceipts O\nprice O\nof O\nits O\ninitial O\noffering O\n, O\nwhich O\nwas O\noversubscribed O\n. O\n\nThe O\ncompany O\n, O\nwhich O\nasked O\nfor O\na O\ntwo-week O\ndelay O\nfrom O\nthe O\nusual O\nAugust O\n15 O\ndeadline O\nfor O\nreporting O\nfirst-half O\nresults O\n, O\nclosed O\non O\nTuesday O\nat O\n5,800 O\nforints O\n, O\ndown O\n300 O\n. O\n\n\" O\nCofinec B-ORG\n's O\nfirst-half O\nfigures O\nwill O\nbe O\n... O\n\nbetween O\none-third O\nof O\ntwo-fifths O\nof O\nits O\nannual O\nplan O\n, O\n\" O\nsaid O\nTamas B-PER\nErdei I-PER\n, O\na O\nBudapest-based B-MISC\nanalyst O\nfor O\nABN-AMRO B-ORG\nHoare I-ORG\nGovett I-ORG\n. O\n\nAnalysts O\nblame O\n, O\nat O\nleast O\npartly O\n, O\nHungary B-LOC\n's O\nmacroeconomic O\nenvironment O\nfor O\nthe O\nweaker O\nfigures O\nfor O\nCofinec B-ORG\nwhich O\n, O\noperating O\nin O\nHungary B-LOC\n, O\nPoland B-LOC\nand O\nthe O\nCzech B-LOC\nRepublic I-LOC\n, O\nnow O\ngenerates O\nabout O\n55 O\nto O\n60 O\npercent O\nof O\nits O\nannual O\nsales O\nfrom O\nHungary B-LOC\n. O\n\nHungary B-LOC\n's O\nGross O\nDomestic O\nProduct O\nfell O\none O\npercentage O\npoint O\nin O\nthe O\nfirst O\nquarter O\nwhile O\nreal O\nwages O\nplunged O\n7.2 O\npercentage O\npoints O\nin O\nthe O\nfirst O\nhalf O\nof O\n1996 O\n. O\n\nBoth O\nwill O\nhave O\ntheir O\nimpact O\non O\nCofinec B-ORG\n's O\nfigures O\n, O\nthe O\nanalysts O\nsaid O\n. O\n\nDespite O\nthe O\ncurrent O\ndifficulties O\n, O\nhowever O\n, O\nanalysts O\nwere O\nconvinced O\nthat O\nCofinec B-ORG\n's O\noutlook O\nwas O\nstrong O\n. O\n\n\" O\nThe O\neastern O\nEuropean B-MISC\nmarket O\noffers O\ngood O\nchances O\n, O\n\" O\nsaid O\nErdei B-PER\n. O\n\" O\n\nJust O\nlike O\nmany O\nother O\ncompanies O\non O\nthe O\nbourse O\n, O\nCofinec B-ORG\nhas O\nbig O\ngrowth O\nopportunities O\n. O\n\" O\n\n\" O\nAt O\nthe O\nsame O\ntime O\n, O\nit O\n's O\nan O\nadvantage O\nfor O\nCofinec B-ORG\nthat O\nit O\nhas O\na O\nforeign O\nmanagement O\nwhich O\nperhaps O\nunderstands O\nthe O\nmarket O\nbetter O\n, O\n\" O\nErdei B-PER\nadded O\n. O\n\n\" O\nCofinec B-ORG\nis O\na O\nvery O\ngood O\nstory O\nin O\nthe O\nlong-term O\nas O\nthe O\nper O\ncapita O\npackaging O\nconsumption O\nis O\nstill O\nso O\nlow O\nin O\neast O\nEurope B-LOC\nthat O\na O\nvery O\nstrong O\nincrease O\ncan O\nbe O\nexpected O\n( O\nlong-term O\n) O\n, O\n\" O\nSitanyi B-PER\nsaid O\n, O\nsaying O\nthat O\nseveral O\nrecent O\nmoves O\nby O\nCofinec B-ORG\nboosted O\nits O\nposition O\n. O\n\nAmong O\nthem O\n, O\nhe O\nnoted O\nthat O\nCofinec B-ORG\nhad O\nacquired O\nthe O\noutstanding O\nstake O\nin O\nits O\nCzech B-MISC\nfolding O\ncompany O\nKrpaco B-ORG\na.s. I-ORG\n, O\nincreasing O\nits O\nownership O\nto O\n100 O\npercent O\n, O\nso O\nin O\nthe O\nsecond O\nhalf O\nthe O\nwhole O\nof O\nKrpaco B-ORG\n's O\nfigures O\nwill O\nbe O\nconsolidated O\n. O\n\nThe O\ncompany O\nalso O\nrepaid O\nsome O\n$ O\n21 O\nmillion O\nof O\ndebt O\n, O\nwell O\nabove O\nthe O\noriginally O\nplanned O\n$ O\n8 O\nmillion O\nto O\n$ O\n9 O\nmillion O\n. O\n\nIn O\naddition O\n, O\nits O\nPolish B-MISC\noperation O\nbegan O\nwith O\nsome O\nsix O\nweeks O\nof O\ndelay O\ndue O\nto O\ncold O\nwinter O\nweather O\nand O\nthe O\ntest O\nrun O\nwas O\nalso O\nlonger O\nthan O\nplanned O\n. O\n\n-- O\nBudapest B-LOC\nnewsroom O\n( O\n36 O\n1 O\n) O\n266 O\n2410 O\n\n-DOCSTART- O\n\nDIRECT O\nEQUITY O\nTRADES O\nON O\nTHE O\nCZECH B-MISC\nPSE B-ORG\n- O\nAUG O\n27 O\n. O\n\nPRAGUE B-LOC\n1996-08-27 O\n\nThe O\nfollowing O\nis O\na O\nlist O\nof O\n\ndirect O\nequity O\ntrades O\nmade O\non O\nthe O\nPrague B-ORG\nStock I-ORG\nExchange I-ORG\n: O\n\nISSUE O\nMin O\n. O\n\nPrice O\nMax O\n. O\n\nPrice O\nVolume O\nTurnover O\n\n( O\nCZK O\n) O\n( O\nCZK O\n) O\n( O\nshares O\n) O\n( O\nCZK O\n000 O\n's O\n) O\n\nAGROTONZ B-ORG\nTLUMACOV I-ORG\n336.47 O\n336.47 O\n59440 O\n19999.777 O\n\nAVIA B-ORG\n290.00 O\n290.00 O\n700 O\n203.000 O\n\nBARUM B-ORG\nHOLDING I-ORG\n171.00 O\n171.00 O\n14432 O\n2467.872 O\n\nCESKA B-ORG\nSPORITELNA I-ORG\n335.00 O\n375.00 O\n533153 O\n198354.941 O\n\nCKD B-ORG\nPRAHA I-ORG\nHOLDING I-ORG\n369.66 O\n384.00 O\n5565 O\n2065.260 O\n\nEMKAM B-ORG\n25.00 O\n25.00 O\n34684 O\n867.100 O\n\nKABLO B-ORG\nKLADNO I-ORG\n960.00 O\n960.00 O\n2230 O\n2140.800 O\n\nKOMERCNI B-ORG\nBANKA I-ORG\n2320.00 O\n2370.00 O\n7000 O\n16408.700 O\n\nLECIVA B-ORG\nPRAHA I-ORG\n2470.00 O\n2470.00 O\n1360 O\n3359.200 O\n\nMETROSTAV B-ORG\n3024.95 O\n3024.95 O\n3000 O\n9074.850 O\n\nMORAV.CHEMIC. B-ORG\nZAV I-ORG\n. O\n\n637.50 O\n637.50 O\n1626 O\n1036.575 O\n\nOKD B-ORG\n111.50 O\n112.56 O\n95975 O\n10752.092 O\n\nPF B-ORG\nIKS I-ORG\nKB I-ORG\nPLUS I-ORG\n156.00 O\n156.00 O\n6000 O\n936.000 O\n\nRIF B-ORG\n900.00 O\n900.00 O\n5500 O\n4950.000 O\n\nSELIKO B-ORG\n4000.00 O\n20000.00 O\n3565 O\n32607.500 O\n\nSOKOLOVSKA B-ORG\nUHELNA I-ORG\n785.00 O\n785.00 O\n6000 O\n4710.000 O\n\nSPIF B-ORG\nCESKY I-ORG\n339.00 O\n340.00 O\n7546 O\n2562.094 O\n\nSPT B-ORG\nTELECOM I-ORG\n3355.00 O\n3404.71 O\n10700 O\n36337.137 O\n\nSKODA B-ORG\nPLZEN I-ORG\n1045.56 O\n1060.00 O\n10772 O\n11361.330 O\n\nTABAK B-ORG\n6700.00 O\n6700.00 O\n1000 O\n6700.000 O\n\nTRINECKE B-ORG\nZELEZARNY I-ORG\n210.00 O\n210.00 O\n3000 O\n630.000 O\n\nVODNI B-ORG\nSTAVBY I-ORG\nPRAHA I-ORG\n1915.00 O\n1915.00 O\n2000 O\n3830.000 O\n\n-- O\nPrague B-ORG\nNewsroom I-ORG\n, O\n42-2-2423-0003 O\n\n-DOCSTART- O\n\nAFTER O\nTHE O\nBELL O\n- O\nAfter O\nhours O\nslows O\nin O\nlight O\nvolume O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-27 O\n\nTraders O\nsaid O\non O\nTuesday O\nafter-hours O\nactivity O\nwas O\nlight O\n. O\n\nBoth O\nWorldCom B-ORG\nInc I-ORG\nand O\nMFS B-ORG\nCommunications I-ORG\nCo I-ORG\nInc I-ORG\nwere O\ntrading O\nbut O\nthey O\nmoved O\nin O\nline O\nwith O\ntheir O\nclose O\n. O\n\nWorldCom B-ORG\n, O\nwhich O\nsaid O\nit O\nwill O\nbuy O\nMFS B-ORG\n, O\nshed O\n1-3/4 O\nto O\nclose O\nat O\n21 O\nwhile O\nMFS B-ORG\nlost O\n3-8/16 O\nto O\nclose O\nat O\n41-5/16 O\n. O\n\nThe O\nNew B-ORG\nYork I-ORG\nStock I-ORG\nExchange I-ORG\nsaid O\nits O\nsession O\none O\nvolume O\nwas O\n5,700 O\nshares O\ncompared O\nto O\n53,400 O\nshares O\nMonday O\n. O\n\nSession O\ntwo O\nvolume O\nwas O\n4,153,800 O\nshares O\ncompared O\nto O\nno O\nvolume O\nMonday O\n. O\n\nThe O\nAmerican B-ORG\nStock I-ORG\nExchange I-ORG\nsaid O\nthere O\nwas O\nno O\nafter-hours O\nactivity O\n. O\n\n-DOCSTART- O\n\nCBOE B-ORG\nin O\nroutine O\nreview O\nof O\nMFS B-ORG\noptions O\n. O\n\nCHICAGO B-LOC\n1996-08-27 O\n\nThe O\nChicago B-ORG\nBoard I-ORG\nOptions I-ORG\nExchange I-ORG\n( O\nCBOE B-ORG\n) O\nsaid O\non O\nTuesday O\nit O\nwas O\ndoing O\na O\nroutine O\ninvestigation O\ninto O\ntrading O\nin O\noptions O\non O\nMFS B-ORG\nCommunications I-ORG\nCo I-ORG\nInc I-ORG\nshares O\n. O\n\nOn O\nMonday O\n, O\nthe O\ncompany O\nsaid O\nit O\nhad O\nagreed O\nto O\nbe O\nacquired O\nby O\nWorldCom B-ORG\nInc I-ORG\nin O\na O\ndeal O\nvalued O\nat O\n$ O\n14 O\nbillion O\n. O\n\nMFS B-ORG\nshares O\nsurged O\non O\nthe O\nnews O\nwhile O\nWorldCom B-ORG\nfell O\non O\nfears O\nof O\ndilution O\n. O\n\nThe B-ORG\nNew I-ORG\nYork I-ORG\nTimes I-ORG\nsaid O\non O\nTuesday O\nsome O\nof O\nthe O\noptions O\ntrading O\nin O\nMFS B-ORG\nlast O\nFriday O\nmay O\nsuggest O\ninsider O\ntrading O\n. O\n\nMFS B-ORG\noptions O\nalso O\ntrade O\non O\nthe O\nAmerican B-ORG\nStock I-ORG\nExchange I-ORG\nand O\nthe O\nPacific B-ORG\nStock I-ORG\nExchange I-ORG\n. O\n\nA O\nspokesman O\nfor O\nthe O\nAmerican B-ORG\nStock I-ORG\nExchange I-ORG\nwould O\nneither O\nconfirm O\nor O\ndeny O\nwhether O\nthe O\nexchange O\nwas O\nlooking O\ninto O\ntrading O\n. O\n\n\" O\nIf O\nthere O\nis O\nunusual O\nactivity O\n, O\ncertainly O\nwe O\nlook O\nat O\nit O\n, O\nbut O\nthat O\n's O\nnot O\nto O\nsay O\nwe O\n're O\ndoing O\nanything O\nofficial O\n, O\n\" O\nhe O\nsaid O\n. O\n\nPacific B-ORG\nStock I-ORG\nExchange I-ORG\nofficials O\nwere O\nnot O\navailable O\n. O\n\nOne O\ntrader O\nsaid O\ntrading O\nin O\nMFS B-ORG\noptions O\nhad O\nincreased O\nsteadily O\nfrom O\nabout O\nmid-August O\n, O\nand O\ndoubted O\nwhether O\nany O\nof O\nlast O\nFriday O\n's O\nactivity O\nwas O\ninsider O\ntrading O\n. O\n\n- O\nDerivatives O\ndesk O\n, O\n312 O\n408-8750 O\n/ O\nE-mail O\n: O\nderivatives@reuters.com O\n\n-DOCSTART- O\n\nFaulding B-ORG\ntarget O\nof O\npatent O\nlawsuit O\n. O\n\nELIZABETH B-LOC\n, O\nN.J. B-LOC\n1996-08-27 O\n\nFaulding B-ORG\nInc I-ORG\nsaid O\non O\nTuesday O\nPurdue B-ORG\nFrederick I-ORG\nCo I-ORG\nfiled O\na O\npatent O\ninfringement O\nlawsuit O\nagainst O\nFaulding B-ORG\nand O\nits O\nPurepac B-ORG\nPharamceutical I-ORG\nunit O\n. O\n\nThe O\nsuit O\nwas O\nfiled O\nbecause O\nof O\nPurepac B-ORG\n's O\nmanufacture O\nof O\nKadian B-MISC\n, O\na O\nsustained O\nrelease O\nmorphine O\nproduct O\n, O\nFaulding B-ORG\nsaid O\n. O\n\nFaulding B-ORG\nsaid O\nthe O\nclaims O\nin O\nthe O\nlawsuit O\nare O\nwithout O\nmerit O\nand O\nwill O\nnot O\nimpact O\nupon O\nthe O\nlaunch O\nof O\nKadian B-MISC\nin O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\nKadian B-MISC\nwas O\napproved O\nfor O\nsale O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\nlast O\nmonth O\n, O\nFaulding B-ORG\nsaid O\n. O\n\nZeneca B-ORG\nGroup I-ORG\nPlc I-ORG\n, O\nwhich O\nwill O\nmarket O\nKadian B-MISC\n, O\nwas O\nnamed O\nin O\nthe O\nlawsuit O\nwith O\nF.H. B-ORG\nFaulding I-ORG\n& I-ORG\nCo I-ORG\n, O\nthe O\nmajority O\nshareholder O\nof O\nFaulding B-ORG\nInc I-ORG\n, O\nthe O\ncompany O\nsaid O\n. O\n\n-DOCSTART- O\n\nMcGrath B-PER\nleft O\nout O\nof O\nIreland B-LOC\nWorld B-MISC\nCup I-MISC\nsquad O\n. O\n\nDUBLIN B-LOC\n1996-08-27 O\n\nIreland B-LOC\n's O\nmost O\nexperienced O\nplayer O\n, O\ndefender O\nPaul B-PER\nMcGrath I-PER\n, O\nwas O\nleft O\nout O\nof O\nthe O\nnational O\nsquad O\nfor O\nthe O\nfirst O\ntime O\nin O\n11 O\nyears O\non O\nTuesday O\nwhen O\nnew O\nmanager O\nMick B-PER\nMcCarthy I-PER\nnamed O\nhis O\nside O\nto O\nface O\nLiechtenstein B-LOC\nin O\na O\nWorld B-MISC\nCup I-MISC\nqualifier O\n. O\n\nThe O\n36-year-old O\nAston B-ORG\nVilla I-ORG\nplayer O\nwon O\nthe O\nlast O\nof O\nhis O\nIrish B-MISC\nrecord O\nof O\n82 O\ninternational O\ncaps O\nagainst O\nthe O\nCzech B-LOC\nRepublic I-LOC\nin O\nPrague B-LOC\nin O\nApril O\n. O\n\n\" O\nPaul B-PER\naccepted O\nthe O\nsituation O\n. O\n\nHe O\nhas O\nn't O\nplayed O\nany O\nfirst-team O\ngames O\nfor O\nVilla B-PER\nthis O\nseason O\nand O\nhe O\n's O\nnot O\nthe O\ntype O\nof O\nplayer O\nI O\nwould O\nhave O\nbrought O\non O\nas O\na O\nsubstitute O\n, O\n\" O\nMcCarthy B-PER\nsaid O\n. O\n\" O\n\nBut O\nhe O\nsurprised O\nme O\nin O\ntraining O\nover O\nthe O\nlast O\ntwo O\ndays O\nbecause O\nof O\nhis O\ninvolvement O\n. O\n\nHe O\n's O\ncertainly O\nis O\nstill O\nvery O\nmuch O\npart O\nof O\nmy O\nplans O\nfor O\nthe O\nfuture O\n. O\n\n\" O\nAt O\n24 O\n, O\n25 O\nor O\n26 O\nyou O\ncould O\nget O\naway O\nwith O\nit O\n, O\nnot O\nhaving O\nplayed O\nfirst-team O\ngames O\n. O\n\nBut O\nat O\n36 O\nit O\nwould O\nbe O\nasking O\ntoo O\nmuch O\nof O\nPaul B-PER\n, O\n\" O\nhe O\nsaid O\n. O\n\nAlso O\nomitted O\nfrom O\nthe O\n20-man O\nsquad O\nwhich O\nwill O\ntravel O\nto O\nVaduz B-LOC\nfor O\nSaturday O\n's O\ngroup O\neight O\nmatch O\nare O\ncentral O\ndefenders O\nAlan B-PER\nKernaghan I-PER\nand O\nLiam B-PER\nDaish I-PER\n. O\n\nLeeds B-ORG\nUnited I-ORG\ndefender O\nGary B-PER\nKelly I-PER\nis O\nunable O\nto O\ntravel O\nbecause O\nof O\na O\nknee O\ninjury O\npicked O\nup O\nin O\nMonday O\n's O\n1-0 O\nvictory O\nover O\nWimbledon B-ORG\nat O\nElland B-LOC\nRoad I-LOC\n. O\n\nSince O\ntaking O\nover O\nfrom O\nJack B-PER\nCharlton I-PER\nin O\nFebruary O\n, O\nMcCarthy B-PER\nhas O\nplayed O\nlargely O\nexperimental O\nsides O\nand O\nseen O\nthem O\nlose O\nfive O\ntimes O\n, O\ndraw O\ntwice O\nand O\nwin O\njust O\nonce O\n. O\n\nSquad O\n: O\nAlan B-PER\nKelly I-PER\n, O\nShay B-PER\nGiven I-PER\n, O\nDenis B-PER\nIrwin I-PER\n, O\nPhil B-PER\nBabb I-PER\n, O\nJeff B-PER\nKenna I-PER\n, O\nCurtis B-PER\nFleming I-PER\n, O\nGary B-PER\nBreen I-PER\n, O\nIan B-PER\nHarte I-PER\n, O\nKenny B-PER\nCunningham I-PER\n, O\nSteve B-PER\nStaunton I-PER\n, O\nAndy B-PER\nTownsend I-PER\n, O\nRay B-PER\nHoughton I-PER\n, O\nGareth B-PER\nFarrelly I-PER\n, O\nAlan B-PER\nMcLoughlin I-PER\n, O\nJason B-PER\nMcAteer I-PER\n, O\nAlan B-PER\nMoore I-PER\n, O\nKeith B-PER\nO'Neill I-PER\n, O\nTony B-PER\nCascarino I-PER\n, O\nNiall B-PER\nQuinn I-PER\n, O\nDavid B-PER\nKelly I-PER\n. O\n\n-- O\nDublin B-ORG\nNewsroom I-ORG\n+6613377 O\n\n-DOCSTART- O\n\nS. B-MISC\nAfrican I-MISC\napartheid O\nkiller O\nconvicted O\nof O\nsix O\nmurders O\n. O\n\nPRETORIA B-LOC\n1996-08-27 O\n\nSouth B-MISC\nAfrican I-MISC\napartheid O\nkiller O\nEugene B-PER\nde I-PER\nKock I-PER\nwas O\nfound O\nguilty O\nof O\nmurder O\nand O\nattempted O\nmurder O\non O\nTuesday O\n, O\na O\nday O\nafter O\nhe O\nwas O\nconvicted O\nof O\nfive O\nother O\nmurders O\n. O\n\nDe B-PER\nKock I-PER\n, O\n48 O\n, O\na O\nformer O\npolice O\ncolonel O\nwho O\ncommanded O\na O\nhit-squad O\nthat O\nwiped O\nout O\nopponents O\nof O\napartheid O\n, O\nis O\nthe O\nmost O\nsenior O\nservant O\nof O\nwhite O\nrule O\nyet O\nto O\nface O\njustice O\n. O\n\n-DOCSTART- O\n\nSudanese B-MISC\nrebels O\nsay O\nmissionaries O\nshould O\nbe O\nfreed O\n. O\n\nPeter B-PER\nSmerdon I-PER\n\nNAIROBI B-LOC\n1996-08-27 O\n\nThe O\nmain O\nrebel O\ngroup O\nin O\nsouth O\nSudan B-LOC\nsaid O\non O\nTuesday O\nit O\nwas O\ntrying O\nto O\narrange O\nthe O\nrelease O\nof O\nsix O\nRoman B-MISC\nCatholic I-MISC\nmissionaries O\n, O\nincluding O\nthree O\nAustralian B-MISC\nnuns O\n, O\nheld O\nfor O\nnearly O\ntwo O\nweeks O\n. O\n\nGeorge B-PER\nGarang I-PER\n, O\nNairobi B-LOC\nspokesman O\nfor O\nthe O\nSudan B-ORG\nPeople I-ORG\n's I-ORG\nLiberation I-ORG\nArmy I-ORG\n( O\nSPLA B-ORG\n) O\n, O\nsaid O\nit O\nwas O\nurgently O\ntrying O\nto O\ncontact O\nSPLA B-ORG\ncommander O\nNuour B-PER\nMarial I-PER\nat O\nMapourdit B-LOC\nin O\nthe O\nsouth O\nto O\nfree O\nthe O\nsix O\n. O\n\n\" O\nThe O\nmovement O\nis O\nmaking O\narrangements O\nfor O\nthem O\nto O\nbe O\nset O\nfree O\n. O\n\nThis O\nis O\na O\ndecision O\nof O\nthe O\nleadership O\n, O\n\" O\nGarang B-PER\nsaid O\n. O\n\n\" O\nCommander O\nNuour B-PER\nMarial I-PER\nis O\na O\nsoldier O\nso O\nhe O\nmust O\naccept O\nthe O\nleadership O\n's O\ndecision O\n. O\n\nBut O\ncommunications O\nat O\nthis O\ntime O\nof O\nyear O\nare O\nvery O\ndifficult O\nbecause O\nof O\nrains O\nand O\na O\nlack O\nof O\npower O\n, O\n\" O\nhe O\nadded O\n. O\n\nThe O\nCatholic B-ORG\nInformation I-ORG\nOffice I-ORG\nin O\nNairobi B-LOC\nsaid O\non O\nMonday O\nthat O\nfour O\nof O\nthe O\nsix O\nhad O\nbeen O\ncharged O\nby O\nthe O\nSPLA B-ORG\nwith O\nspying O\n, O\nspreading O\nIslam B-MISC\nand O\nhindering O\nrecruitment O\ninto O\nthe O\nrebel O\ngroup O\n. O\n\n\" O\nThese O\ncharges O\nare O\nthe O\ninterpretation O\nof O\nthe O\nchurch O\n, O\n\" O\nGarang B-PER\nsaid O\non O\nTuesday O\n. O\n\" O\n\nWe O\nhave O\nno O\nidea O\nwhy O\nthey O\nare O\nbeing O\nheld O\n. O\n\nWe O\nare O\nstill O\ntrying O\nto O\nestablish O\ncontact O\nwith O\nthe O\nlocal O\ncommander O\n. O\n\" O\n\nAsked O\nwhether O\nthis O\nmeant O\nthe O\ncommander O\nwas O\nout O\nof O\ncontrol O\n, O\nGarang B-PER\nsaid O\nthe O\nrebel O\nmovement O\nwas O\nworking O\non O\nthe O\nproblem O\n. O\n\nHe O\nsaid O\nhe O\nbelieved O\nall O\nsix O\nwere O\nbeing O\nheld O\nin O\nthe O\nmission O\ncompound O\nat O\nMapourdit B-LOC\nand O\nwere O\nreported O\nto O\nbe O\nin O\ngood O\nhealth O\n. O\n\nThe O\nCatholic B-ORG\nInformation I-ORG\noffice I-ORG\nin O\nNairobi B-LOC\nsaid O\non O\nMonday O\nthat O\nAustralian B-MISC\nSisters O\nMoira B-PER\nLynch I-PER\n, O\n73 O\n, O\nand O\nMary B-PER\nBatchelor I-PER\n, O\n68 O\n, O\nAmerican B-MISC\nFather O\nMichael B-PER\nBarton I-PER\n, O\n48 O\n, O\nand O\nSudanese B-MISC\nFather O\nRaphael B-PER\nRiel I-PER\n, O\n48 O\n, O\nwere O\nheld O\nin O\na O\nprison O\nin O\nsouth O\nSudan B-LOC\nby O\nthe O\nSPLA B-ORG\n. O\n\nIt O\nsaid O\nAustralian B-MISC\nSister O\nMaureen B-PER\nCarey I-PER\n, O\n52 O\n, O\nand O\nItalian B-MISC\nBrother O\nRaniero B-PER\nIacomella I-PER\n, O\n28 O\n, O\nwere O\nheld O\ninside O\nthe O\ncompound O\n. O\n\nThe O\nchurch O\nin O\nAustralia B-LOC\nsaid O\non O\nMonday O\nLynch B-PER\n, O\nBatchelor B-PER\n, O\nBarton B-PER\nand O\nRiel B-LOC\nwere O\nheld O\nin O\na O\nprison O\nuntil O\nthe O\nweekend O\n, O\nwhen O\nthey O\nwere O\nmoved O\nto O\njoin O\nthe O\nother O\ncaptives O\nat O\nthe O\ncompound O\n. O\n\nThe O\nCatholic B-ORG\nInformation I-ORG\nOffice I-ORG\nsaid O\nthe O\nSPLA B-ORG\nin O\nthe O\nKenyan B-MISC\ncapital O\nhad O\nattributed O\nthe O\ndetentions O\nof O\nthe O\nsix O\nto O\na O\nlocal O\ncommander O\nand O\nhad O\npromised O\nthey O\nwould O\nbe O\nfreed O\nby O\nAugust O\n23 O\n. O\n\nBut O\nthe O\nchurch O\nlearned O\nin O\na O\nrecent O\nmeeting O\nwith O\nthe O\nlocal O\ncommander O\nthat O\nno O\ninstructions O\nto O\nrelease O\nthe O\nprisoners O\nwere O\nreceived O\nand O\nthey O\nwould O\nbe O\nheld O\nuntil O\ninvestigations O\nwere O\ncompleted O\n. O\n\nIt O\nsaid O\nlast O\nFriday O\nthey O\nwere O\nvisited O\nby O\nMonsignor O\nCaesar B-PER\nMazzolari I-PER\n, O\napostolic O\nadministrator O\nof O\nthe O\ndiocese O\nof O\nRumbek B-LOC\nin O\nsouthern O\nSudan B-LOC\n, O\nand O\nan O\nSPLA B-ORG\nadministrator O\nand O\nappeared O\nin O\ngood O\ncondition O\n. O\n\n\" O\nOn O\nAugust O\n17 O\nthe O\nmission O\nwas O\nsurrounded O\n( O\nby O\nthe O\nSPLA B-ORG\n) O\nand O\nsealed O\noff O\n. O\n\nThe O\nevening O\nof O\nthe O\nsame O\nday O\nthe O\nmissionaries O\nwere O\nput O\nin O\nprison O\nor O\nisolation O\n. O\n\nLater O\nthe O\nmission O\nwas O\nlooted O\n, O\n\" O\nit O\nadded O\n. O\n\nAn O\nAustralian B-MISC\nforeign O\nministry O\nofficial O\nsaid O\nthe O\ncharges O\nagainst O\nthem O\nwere O\n\" O\nfairly O\nbizarre O\n\" O\nand O\na O\nmatter O\nfor O\nconcern O\n. O\n\nHe O\nsaid O\nAustralian B-MISC\ndiplomats O\nin O\nNairobi B-LOC\nwere O\nworking O\nwith O\nthe O\nRoman B-MISC\nCatholic I-MISC\nchurch O\nin O\nsouthern O\nSudan B-LOC\nand O\nwith O\nU.S. B-LOC\nand O\nItalian B-MISC\ndiplomats O\nin O\nthe O\nregion O\nto O\nhelp O\nfree O\nthe O\nmissionaries O\n. O\n\nThe O\nSPLA B-ORG\nhas O\nfought O\nKhartoum B-LOC\n's O\ngovernment O\nforces O\nin O\nthe O\nsouth O\nsince O\n1983 O\nfor O\ngreater O\nautonomy O\nor O\nindependence O\nof O\nthe O\nmainly O\nChristian B-MISC\nand O\nanimist O\nregion O\nfrom O\nthe O\nMoslem B-MISC\n, O\nArabised B-LOC\nnorth I-LOC\n. O\n\n-DOCSTART- O\n\nOSCE B-ORG\npostpones O\nBosnian B-MISC\nmunicipal O\nelections O\n. O\n\nSARAJEVO B-LOC\n1996-08-27 O\n\nThe O\nU.S. B-LOC\ndiplomat O\nin O\ncharge O\nof O\nelections O\nin O\nBosnia B-LOC\nannounced O\non O\nTuesday O\nthat O\nvoting O\nfor O\nmunicipal O\nassemblies O\nwould O\nbe O\npostponed O\nbecause O\nof O\nirregularities O\nby O\nthe O\nSerbs B-MISC\nin O\nregistering O\nvoters O\n. O\n\nAmbassador O\nRobert B-PER\nFrowick I-PER\n, O\nrepresenting O\nthe O\nOrganisation B-ORG\nfor I-ORG\nSecurity I-ORG\nand I-ORG\nCooperation I-ORG\nin I-ORG\nEurope I-ORG\n( O\nOSCE B-ORG\n) O\n, O\ntold O\nreporters O\nthat O\nmunicipal O\npolls O\ndue O\non O\nSeptember O\n14 O\nwith O\nother O\nBosnian B-MISC\nelections O\nwould O\nbe O\nput O\noff O\n. O\n\n\" O\nI O\nhave O\nmade O\na O\nchairman O\n's O\ndecision O\nthat O\nit O\nis O\nnot O\nfeasible O\nto O\nhold O\nmunicipal O\nelections O\non O\nSeptember O\n14 O\n, O\n\" O\nsaid O\nFrowick B-PER\n. O\n\nHe O\nsaid O\nno O\nexact O\ndate O\nhad O\nbeen O\nset O\nbut O\nit O\nwas O\npossible O\nthe O\nlocal O\nelections O\nwould O\ntake O\nplace O\nin O\nthe O\nspring O\nof O\n1997 O\n. O\n\nAccording O\nto O\nOSCE B-ORG\nofficials O\n, O\nSerb B-MISC\nauthorities O\nhave O\npressed O\ntheir O\nrefugees O\nto O\nregister O\nto O\nvote O\nin O\ntowns O\nnow O\nunder O\nSerb B-MISC\ncontrol O\n, O\nbut O\nwhich O\nused O\nto O\nhave O\nMoslem B-MISC\nmajorities O\n. O\n\nHuman O\nrights O\nworkers O\nsay O\nauthorities O\nin O\nSerbia B-LOC\nand O\nBosnian B-MISC\nSerb I-MISC\nterritory O\nhave O\nconducted O\na O\nwell-organised O\ncampaign O\nto O\ncoerce O\nrefugees O\ninto O\nregistering O\nonly O\non O\nSerb B-MISC\nterritory O\nand O\nfailed O\nto O\ninform O\nthem O\nof O\ntheir O\nrights O\nunder O\nthe O\nDayton B-LOC\npeace O\nagreement O\n. O\n\nDiplomats O\nsay O\nthe O\neffect O\nof O\nthe O\nelectoral O\nengineering O\nwould O\nbe O\nto O\nestablish O\npolitical O\ncontrol O\nover O\ndistricts O\nthey O\nconquered O\nand O\nethnically O\ncleansed O\nin O\nwar O\n. O\n\nThe O\nresponse O\nof O\nthe O\nBosnian B-MISC\nSerbs I-MISC\nto O\nthe O\nOSCE B-ORG\n's O\nannouncement O\nwas O\nnot O\nimmediately O\nclear O\n. O\n\nBut O\nBosnian B-MISC\nSerb I-MISC\nleaders O\nhave O\nhinted O\nthey O\nwould O\nboycott O\nthe O\npoll O\nif O\nthe O\nmunicipal O\nelections O\nwere O\npostponed O\n, O\nor O\ngo O\nahead O\nwith O\ntheir O\nown O\n. O\n\nThe O\nBosnian B-MISC\nSerb I-MISC\ncabinet O\n, O\nin O\na O\nletter O\nto O\nthe O\nOSCE B-ORG\n, O\nsaid O\non O\nMonday O\nthat O\nany O\ndelay O\nof O\nlocal O\nelections O\nwould O\nbe O\n\" O\na O\ndirect O\nand O\nflagrant O\nviolation O\nfo O\nthe O\nDayton B-LOC\nagreement O\n\" O\n. O\n\nThe O\nSerbs B-MISC\n, O\nwho O\nadminister O\nhalf O\nof O\nBosnia B-LOC\nin O\na O\nSerb B-MISC\nrepublic O\n, O\nsaid O\nthey O\nhad O\nmet O\nall O\nconditions O\nfor O\nholding O\nthe O\nSeptember O\nelections O\n. O\n\nDiplomats O\nfear O\nthat O\nthe O\ncrisis O\ncould O\ncast O\ndoubt O\nover O\nthe O\nentire O\nelection O\nprocess O\n, O\nwhich O\nalready O\nappears O\nset O\nto O\nconfirm O\nBosnia B-LOC\n's O\nethnic O\npartition O\nrather O\nthan O\nits O\nreintegration O\nas O\nthe O\nDayton B-LOC\npeace O\nagreement O\nhad O\nplanned O\n. O\n\n-DOCSTART- O\n\nNew O\ntalks O\nin O\nChechnya B-LOC\nas O\nLebed B-PER\nwaits O\nfor O\nYeltsin B-PER\n. O\n\nDmitry B-PER\nKuznets I-PER\n\nNOVYE B-LOC\nATAGI I-LOC\n, O\nRussia B-LOC\n1996-08-27 O\n\nRussian B-MISC\nand O\nrebel O\nmilitary O\ncommanders O\nfinally O\nmet O\nin O\nChechnya B-LOC\non O\nTuesday O\nfor O\ndelayed O\ntalks O\naimed O\nat O\nfinalising O\na O\nceasefire O\narranged O\nlast O\nweek O\nby O\nPresident O\nBoris B-PER\nYeltsin I-PER\n's O\nenvoy O\nAlexander B-PER\nLebed I-PER\n. O\n\nThe O\nRussian B-MISC\narmy O\ncommander O\nin O\nthe O\nregion O\n, O\nGeneral O\nVyacheslav B-PER\nTikhomirov I-PER\n, O\narrived O\nat O\nthe O\nrebel-held O\nvillage O\nof O\nNovye B-LOC\nAtagi I-LOC\n, O\nsome O\n20 O\nkm O\n( O\n12 O\nmiles O\n) O\nsouth O\nof O\nthe O\nChechen B-MISC\ncapital O\nGrozny B-LOC\nfor O\ndiscussions O\nwith O\nrebel O\nchief-of-staff O\nAslan B-PER\nMaskhadov I-PER\n. O\n\nBut O\nLebed B-PER\nhimself O\n, O\nthe O\nKremlin B-LOC\nsecurity O\nchief O\n, O\nis O\nstill O\nwaiting O\nback O\nin O\nMoscow B-LOC\nto O\nmeet O\nYeltsin B-PER\nover O\nhis O\nplans O\nfor O\na O\nlasting O\npolitical O\nsettlement O\nin O\nChechnya B-LOC\n. O\n\nItar-Tass B-ORG\nnews O\nagency O\nquoted O\nthe O\nKremlin B-LOC\npress O\nservice O\nas O\nsaying O\nYeltsin B-PER\n, O\nwho O\nleft O\nfor O\na O\nstate O\nholiday O\nhome O\nnear O\nMoscow B-LOC\non O\nMonday O\n, O\nwould O\nhold O\nno O\nworking O\nmeetings O\non O\nTuesday O\n. O\n\nLebed B-PER\ninterrupted O\ntalks O\nwith O\nChechnya B-LOC\n's O\nseparatists O\non O\na O\npolitical O\ndeal O\non O\nSunday O\n, O\nsaying O\nhe O\nhad O\nto O\nconsult O\nwith O\nYeltsin B-PER\n. O\n\nAfter O\na O\nmeeting O\nfailed O\nto O\nmaterialise O\non O\nMonday O\n, O\nLebed B-PER\n's O\nspokesman O\nsaid O\nhe O\nmight O\nmeet O\nthe O\npresident O\non O\nTuesday O\n. O\n\nBut O\nYeltsin B-PER\n's O\nspokesman O\nrebuffed O\nthe O\nsuggestion O\n, O\nsaying O\nthe O\npresident O\nhad O\nleft O\nMoscow B-LOC\nfor O\na O\nholiday O\nnear O\nthe O\ncapital O\n. O\n\nThe O\nRussians B-MISC\npostponed O\nthe O\ntalks O\nafter O\na O\nChechen B-MISC\nband O\ndisarmed O\na O\ncolumn O\nof O\ninterior B-ORG\nministry I-ORG\ntroops O\non O\nSunday O\n. O\n\nThe O\nChechens B-MISC\nsaid O\na O\nrenegade O\ngroup O\nseized O\nthe O\nweapons O\nand O\nsaid O\non O\nMonday O\nthey O\nhad O\nall O\nbeen O\nreturned O\n. O\n\nThe O\nRussian B-MISC\ncommand O\ninsisted O\nthat O\nnot O\nall O\nthe O\nweapons O\nwere O\nthe O\nsame O\nas O\nthose O\ntaken O\n. O\n\nTass B-ORG\nsaid O\nthe O\nweapons O\nand O\nthe O\npractical O\nimplementation O\nof O\nthe O\nceasefire O\nsigned O\nby O\nLebed B-PER\nand O\nMaskhadov B-PER\nlast O\nThursday O\nwould O\nbe O\non O\nthe O\nagenda O\nof O\ntoday O\n's O\ntalks O\n. O\n\nNeither O\nspoke O\nto O\nreporters O\nbefore O\nthe O\nmeeting O\n, O\nwhich O\nstarted O\naround O\n10.45 O\na.m. O\n( O\n0645 O\nGMT B-MISC\n) O\n. O\n\nAlso O\nin O\nNovye B-LOC\nAtagi I-LOC\non O\nTuesday O\nmorning O\n, O\nwas O\nTim B-PER\nGuldimann I-PER\n, O\nthe O\nSwiss B-MISC\ndiplomat O\nwho O\nheads O\nthe O\nChechnya B-LOC\nmission O\nof O\nthe O\nOrganisation B-ORG\nfor I-ORG\nSecurity I-ORG\nand I-ORG\nCooperation I-ORG\nin I-ORG\nEurope I-ORG\n( O\nOSCE B-ORG\n) O\n. O\n\nGuldimann B-PER\n, O\nwho O\nhelped O\nbroker O\nan O\nearlier O\ntruce O\nin O\nMay O\n, O\nwas O\nnot O\ntaking O\npart O\nin O\nthe O\nTikhomirov-Maskhadov B-MISC\ntalks O\n. O\n\nLebed B-PER\n's O\npeace O\nmission O\nthis O\nmonth O\nhas O\nstopped O\nsome O\nof O\nthe O\nworst O\nfighting O\nof O\nthe O\n20-month-old O\nconflict O\n. O\n\nHowever O\n, O\ntension O\non O\nthe O\nground O\nindicates O\nthat O\nit O\ncould O\nfalter O\nif O\nthe O\nmomentum O\nfor O\na O\nsettlement O\nis O\nnot O\nmaintained O\n. O\n\nThree O\nRussian B-MISC\nservicemen O\nwere O\nwounded O\nin O\na O\ntotal O\nof O\nsix O\nshooting O\nincidents O\novernight O\n, O\nItar-Tass B-ORG\nnews O\nagency O\nquoted O\nthe O\nRussian B-MISC\nmilitary O\nas O\nsaying O\non O\nTuesday O\nmorning O\n. O\n\nRIA B-ORG\nnews O\nagency O\nquoted O\nan O\narmy O\nsource O\naccusing O\nrebel O\nfighters O\nof O\nfailing O\nto O\nturn O\nup O\nfor O\njoint O\nRussian-Chechen B-MISC\npolice O\npatrols O\nin O\nsome O\ndistricts O\nof O\nthe O\ncapital O\nGrozny B-LOC\non O\nTuesday O\n. O\n\nBut O\nthe O\nseparatist O\ncommand O\ntold O\nInterfax B-ORG\nnews O\nagency O\nthe O\npatrols O\n, O\npart O\nof O\nthe O\ntruce O\nbrokered O\nby O\nLebed B-PER\nlast O\nweek O\n, O\nwould O\nbegin O\non O\nTuesday O\nafter O\ndelays O\nfor O\n\" O\ntechnical O\nreasons O\n\" O\n. O\n\nYeltsin B-PER\n's O\nspokesman O\nsaid O\nhe O\nmight O\nmeet O\nofficials O\nduring O\nhis O\nbreak O\n, O\nbut O\nindicated O\nLebed B-PER\nwas O\nlow O\non O\nthe O\nlist O\nby O\nsaying O\nYeltsin B-PER\nwould O\nneed O\ntime O\nto O\nstudy O\nthe O\nproposals O\nbefore O\ntalking O\nto O\nhim O\n. O\n\nRussian B-MISC\nnews O\nagencies O\nalso O\nquoted O\nthe O\nKremlin B-LOC\nspokesman O\nas O\nsaying O\nthat O\nLebed B-PER\n's O\nrepresentatives O\nhad O\nnot O\nsought O\na O\nmeeting O\n, O\nhinting O\nat O\nan O\nattempt O\nby O\nthe O\npresident O\nto O\nput O\nhis O\npopular O\nand O\noutspoken O\nprotege O\nin O\nhis O\nplace O\nwith O\na O\nlesson O\non O\nprotocol O\n. O\n\nYeltsin B-PER\n, O\n65 O\n, O\nhas O\nkept O\na O\nlow O\nprofile O\nsince O\nhe O\nwas O\nreelected O\nin O\nJuly O\n, O\nprompting O\nnew O\nspeculation O\nthat O\nthe O\ntwo O\nheart O\nattacks O\nhe O\nsuffered O\nlast O\nyear O\nand O\na O\nrumoured O\ndrinking O\nproblem O\ncould O\nbe O\ntaking O\ntheir O\ntoll O\n, O\nweakening O\nhis O\ngrip O\non O\naffairs O\nof O\nstate O\n. O\n\nAides O\nhave O\ndismissed O\nsuch O\nspeculation O\n, O\ninsisting O\nthat O\nhe O\nsimply O\nneeds O\na O\nrest O\nafter O\nhis O\nenergetic O\nelection O\ncampaign O\n. O\n\nSome O\nanalysts O\nsay O\nthe O\nKremlin B-LOC\nleader O\n, O\nwhose O\norder O\nsending O\ntroops O\nand O\ntanks O\ninto O\nChechnya B-LOC\nin O\n1994 O\nstarted O\nRussia B-LOC\n's O\nill-fated O\nmilitary O\ncampaign O\n, O\ncould O\nmerely O\nbe O\nreluctant O\nto O\nput O\nhis O\nname O\nto O\na O\npeace O\nprocess O\nwhich O\nmight O\nfall O\napart O\n. O\n\nBut O\nLebed B-PER\n, O\nwho O\nhas O\nno O\nreal O\npower O\nwithout O\nhis O\nboss O\nand O\nhas O\nhinted O\nat O\ndark O\nforces O\nin O\nMoscow B-LOC\nworking O\nagainst O\nhim O\n, O\nappears O\nto O\nthink O\na O\ndeal O\nwill O\nnot O\nstick O\nwithout O\nstrong O\nbacking O\nfrom O\nYeltsin B-PER\n. O\n\nHis O\nproposals O\nhave O\nnot O\nbeen O\nspelled O\nout O\nbut O\nare O\nexpected O\nto O\ninvolve O\na O\ncompromise O\nbetween O\nthe O\nseparatists O\n' O\ndemand O\nfor O\nindependence O\nand O\nMoscow B-LOC\n's O\ninsistence O\nthat O\nChechnya B-LOC\nremain O\npart O\nof O\nthe O\nRussian B-LOC\nFederation I-LOC\n. O\n\n-DOCSTART- O\n\nSlovenia B-LOC\nand O\nPoland B-LOC\ntarget O\nEU B-ORG\n, O\nNATO B-ORG\nmembership O\n. O\n\nLJUBLJANA B-LOC\n1996-08-27 O\n\nSlovenia B-LOC\nand O\nPoland B-LOC\npledged O\nto O\nintensify O\ncooperation O\non O\nTuesday O\nand O\nreinforced O\ntheir O\ndetermination O\nto O\njoin O\nthe O\nEuropean B-ORG\nUnion I-ORG\nand O\nNATO B-ORG\nat O\nthe O\nearliest O\npossible O\ndate O\n. O\n\nPolish B-MISC\nPresident O\nAleksander B-PER\nKwasniewski I-PER\nand O\nhis O\nSlovenian B-MISC\ncounterpart O\n, O\nMilan B-PER\nKucan I-PER\n, O\nmet O\nfor O\ntalks O\nat O\nthe O\nstart O\nof O\na O\ntwo-day O\nvisit O\nto O\nSlovenia B-LOC\nby O\nKwasniewski B-PER\n. O\n\nIt O\nwas O\ntheir O\nfourth O\nmeeting O\nthis O\nyear O\n. O\n\nThey O\nsaid O\nin O\na O\nstatement O\nthey O\nagreed O\nto O\nhave O\nregular O\ntelephone O\ncontact O\nto O\ndiscuss O\nprogress O\nin O\nstrengthening O\nties O\nwith O\nthe O\nWest B-LOC\n. O\n\n\" O\nWe O\nexpect O\nour O\ncooperation O\nwill O\nhelp O\nboth O\ncountries O\ntowards O\nentering O\nthe O\nEuropean B-ORG\nUnion I-ORG\nand O\nNATO B-ORG\n, O\n\" O\nKwasniewski B-PER\nsaid O\n. O\n\n\" O\nWe O\nhave O\nsimilar O\nambitions O\nas O\nfar O\nas O\nour O\ninternal O\ndevelopment O\nand O\ninternational O\nlife O\nis O\nconcerned O\n, O\n\" O\nKucan B-PER\nsaid O\n. O\n\nPoland B-LOC\nand O\nSlovenia B-LOC\nare O\nhoping O\nto O\nbe O\namong O\nthe O\nfirst O\ngroup O\nof O\nformer O\neastern O\nbloc O\ncountries O\nto O\njoin O\nthe O\nEuropean B-ORG\nUnion I-ORG\nand O\nNATO B-ORG\n. O\n\nThey O\nhave O\nalready O\nsigned O\nan O\nassociation O\nagreement O\nwith O\nthe O\nEuropean B-ORG\nUnion I-ORG\nand O\nare O\nboth O\npart O\nof O\nthe O\nCentral B-ORG\nEuropean I-ORG\nFree I-ORG\nTrade I-ORG\nArea I-ORG\n, O\nwhich O\nalso O\ncomprises O\nHungary B-LOC\n, O\nSlovakia B-LOC\nand O\nthe O\nCzech B-LOC\nRepublic I-LOC\n. O\n\nSlovenia B-LOC\n's O\ntrade O\nwith O\nPoland B-LOC\nrose O\nto O\n$ O\n142.3 O\nmillion O\nin O\n1995 O\nfrom O\n$ O\n118.8 O\nmillion O\nin O\n1994 O\n. O\n\nDuring O\nhis O\nvisit O\nto O\nSlovenia B-LOC\n, O\nKwasniewski B-PER\nis O\nalso O\nscheduled O\nto O\nmeet O\nPrime O\nMinister O\nJanez B-PER\nDrnovsek I-PER\n, O\nrepresentatives O\nof O\nSlovenian B-MISC\npolitical O\nparties O\nand O\nrepresentatives O\nof O\nthe O\nChamber B-ORG\nof I-ORG\nEconomy I-ORG\n. O\n\n-DOCSTART- O\n\nNationalists O\nwant O\nIliescu B-PER\nousted O\nfor O\nHungary B-LOC\npact O\n. O\n\nBUCHAREST B-LOC\n1996-08-27 O\n\nJunior O\nNationalist O\nmembers O\nof O\nRomania B-LOC\n's O\nruling O\ncoalition O\ncalled O\non O\nTuesday O\nfor O\nthe O\nimpeachment O\nof O\nPresident O\nIon B-PER\nIliescu I-PER\nfor O\nbacking O\na O\nfriendship O\ntreaty O\nwith O\nneighbouring O\nHungary B-LOC\n. O\n\nIliescu B-PER\n's O\nParty B-ORG\nof I-ORG\nSocial I-ORG\nDemocracy I-ORG\n, O\nthe O\nsenior O\ncoalition O\npartner O\n, O\nimmediately O\ndismissed O\nthe O\nNational B-ORG\nUnity I-ORG\nParty I-ORG\n( O\nPUNR B-ORG\n) O\ndemand O\nas O\ncrude O\nelectioneering O\n. O\n\n\" O\nIt O\nis O\na O\ndesperate O\nmove O\nby O\nthe O\nPUNR B-ORG\n, O\nwhich O\nis O\nlosing O\nits O\nonly O\nreason O\nfor O\nexisting O\nahead O\nof O\nthe O\nelectoral O\ncampaign O\n, O\n\" O\nsaid O\nPDSR B-ORG\nexecutive O\npresident O\nAdrian B-PER\nNastase I-PER\n. O\n\n\" O\nThis O\ntreaty O\nis O\nboth O\nnecessary O\nand O\ngood O\n, O\n\" O\nNastase B-PER\nsaid O\n, O\nadding O\nthat O\nthe O\nPUNR B-ORG\n's O\nstance O\nwas O\nthreatening O\nits O\nposition O\nin O\nthe O\ngovernment O\n. O\n\nThe O\ntreaty O\nagreed O\nunexpectedly O\ntwo O\nweeks O\nago O\nwill O\nend O\nyears O\nof O\ndisputes O\nover O\nthe O\nstatus O\nof O\nRomania B-LOC\n's O\nlarge O\nethnic O\nHungarian B-MISC\nminority O\n. O\n\nIt O\nwill O\nalso O\nboost O\nboth O\ncountries O\n' O\nchances O\nof O\nadmission O\nto O\nNATO B-ORG\nand O\nthe O\nEuropean B-ORG\nUnion I-ORG\n. O\n\n\" O\nIf O\nthey O\n( O\nthe O\nPUNR B-ORG\n) O\nare O\nso O\nvexed O\n, O\nthey O\ncould O\nleave O\nthe O\ngovernment O\n... O\n\nWe O\nmight O\nalso O\nhelp O\nthem O\nto O\ndo O\nit O\n, O\nif O\nthey O\ngo O\non O\nlike O\nthis O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\nPUNR B-ORG\nholds O\nfour O\nkey O\nministries O\n-- O\njustice O\n, O\ntransport O\n, O\nagriculture O\nand O\ncommunications O\n. O\n\nPUNR B-ORG\nleader O\nGheorghe B-PER\nFunar I-PER\nsaid O\nin O\na O\nstatement O\nIliescu B-PER\n, O\nin O\npower O\nsince O\nthe O\nfall O\nof O\ncommunism O\nin O\n1989 O\n, O\nshould O\nbe O\nimpeached O\nfor O\ntreason O\nfor O\ncompromising O\non O\nthe O\nissue O\nof O\nethnic O\nHungarian B-MISC\nminority O\nrights O\nin O\nthe O\ntreaty O\ndue O\nto O\nbe O\nsigned O\nnext O\nmonth O\n. O\n\nFunar B-PER\n's O\ncall O\ncame O\non O\nthe O\neve O\nof O\nthe O\nofficial O\nlaunch O\nof O\nIliescu B-PER\n's O\ncampaign O\nfor O\na O\nnew O\nterm O\nat O\nNovember O\n3 O\npolls O\n. O\n\nHis O\nappeal O\nto O\nthe O\nopposition O\nto O\nback O\nhis O\nattempt O\nto O\noust O\nIliescu B-PER\nwas O\nunlikely O\nto O\nsucceed O\n, O\nanalysts O\nsaid O\n. O\n\nIliescu B-PER\nhas O\ninvited O\npolitical O\nleaders O\nto O\na O\nmeeting O\non O\nThursday O\nto O\ndiscuss O\nthe O\nfinal O\nform O\nof O\nthe O\npact O\nwhich O\nboth O\nRomanian B-MISC\nand O\nHungarian B-MISC\nnationalists O\noppose O\nfor O\ndifferent O\nreasons O\n. O\n\nPresidential O\nofficials O\nwere O\nnot O\navailable O\nto O\ncomment O\non O\nthe O\ncall O\nfor O\nIliescu B-PER\n's O\nimpeachment O\n. O\n\n-DOCSTART- O\n\nEstonian B-MISC\nMPS O\nsee O\nlittle O\nhope O\nof O\nelecting O\npresident O\n. O\n\nBelinda B-PER\nGoldsmith I-PER\n\nTALLINN B-LOC\n1996-08-27 O\n\nEstonia B-LOC\n's O\nparliament O\nfailed O\nfor O\na O\nsecond O\ntime O\nto O\nelect O\na O\npresident O\non O\nTuesday O\n, O\ndealing O\na O\nblow O\nto O\nincumbent O\nLennart B-PER\nMeri I-PER\nand O\npushing O\nthe O\ncountry O\ntowards O\nstalemate O\nin O\nits O\nchoice O\nof O\na O\nnew O\nhead O\nof O\nstate O\n. O\n\nNeither O\nMeri B-PER\n, O\nwho O\noversaw O\nEstonia B-LOC\n's O\nfirst O\nsteps O\ninto O\nstatehood O\nafter O\nthe O\ncollapse O\nof O\nthe O\nSoviet B-LOC\nUnion I-LOC\n, O\nnor O\nhis O\narch-rival O\n, O\nformer O\ncommunist O\nArnold B-PER\nRuutel I-PER\n, O\nhave O\nsecured O\nthe O\n68 O\nvotes O\nnecessary O\nfrom O\nthe O\n101-member O\nparliament O\n. O\n\nMeri B-PER\ngarnered O\n49 O\nvotes O\nand O\nMeri B-PER\n34 O\nin O\nTuesday O\n's O\nballot O\nfor O\nthe O\nfive-year O\npresidency O\nof O\nEstonia B-LOC\n. O\n\nA O\nthird O\nand O\nfinal O\nvote O\nwas O\ndue O\nto O\nbe O\nheld O\nwhen O\nparliament O\nreconvened O\non O\nTuesday O\nbut O\nlegislators O\nwere O\nnot O\nexpecting O\na O\nclear O\nresult O\n. O\n\nIf O\nthere O\nis O\nno O\nresult O\nthe O\ndecision O\nwill O\nbe O\nceded O\nto O\nan O\nelectoral O\ncollege O\n. O\n\n\" O\nThe O\nvotes O\nare O\na O\nstrong O\nmessage O\nto O\nMeri B-PER\nthat O\nhe O\nis O\nnot O\nfavoured O\nby O\nsome O\npoliticians O\nany O\nmore O\n, O\n\" O\nReform B-ORG\nParty I-ORG\nhead O\nHeiki B-PER\nKranich I-PER\ntold O\nReuters B-ORG\n. O\n\nUnder O\na O\nconstitution O\nagreed O\nin O\n1992 O\n, O\na O\nyear O\nafter O\nindependence O\n, O\nthe O\npresident O\nhas O\nno O\nexecutive O\npowers O\n. O\n\nHis O\nonly O\npolitical O\nrole O\nis O\nto O\nsmoothe O\nthe O\nfunctioning O\nof O\ngovernment O\nin O\nperiods O\nof O\ncrisis O\n. O\n\nBut O\nMeri B-PER\n, O\n67 O\n, O\nhas O\nbeen O\naccused O\nin O\nparliament O\nof O\ntaking O\ntoo O\nmuch O\npower O\nand O\nnot O\nalways O\nconsulting O\nparliamentarians O\nbefore O\nmaking O\ndecisions O\n. O\n\nHis O\nrelations O\nwith O\na O\nleftist-led O\ngovernment O\nhave O\nsometimes O\nbeen O\ntense O\n. O\n\nHis O\nsupport O\nin O\nthe O\nfirst O\nround O\nof O\nvoting O\non O\nMonday O\nwas O\nmuch O\nlower O\nthan O\nexpected O\n, O\nscoring O\nonly O\n45 O\nvotes O\n, O\nwhich O\npolitical O\nanalysts O\nput O\ndown O\nas O\na O\nvote O\nof O\nno O\nconfidence O\nin O\nhis O\nperformance O\n. O\n\nThis O\nsupport O\nonly O\ninched O\nup O\nto O\n49 O\nin O\nthe O\nsecond O\nvote O\n. O\n\nSupport O\nfor O\nRuutel B-PER\n, O\n68 O\n, O\nremained O\nconstant O\nat O\n34 O\nvotes O\n. O\n\nIf O\nthe O\nthird O\nvote O\nfails O\nto O\ngive O\neither O\nMeri B-PER\nor O\nRuutel B-PER\n68 O\nvotes O\n, O\nthe O\nparliamentary O\nspeaker O\nwill O\nconvene O\nan O\nelectoral O\ncollege O\nof O\n101 O\nMPs O\nand O\n273 O\nlocal O\ngoverment O\nrepresentatives O\nto O\nhold O\na O\nnew O\npoll O\nthat O\ncould O\ninclude O\nnew O\nnominations O\n. O\n\nThis O\nwould O\nbe O\nthe O\nfirst O\ntime O\nthat O\nthe O\nformer O\nSoviet B-MISC\nrepublic O\nhas O\nhad O\nto O\ncall O\ntogether O\nan O\nelectoral O\ncollege O\n. O\n\nIn O\nits O\nfirst O\npresidential O\nelection O\nin O\n1992 O\nMeri B-PER\nwon O\nthe O\nnecessary O\nvotes O\nin O\nin O\na O\nparliamentary O\nelection O\nagainst O\nRuutel B-PER\n. O\n\nParliamentary O\norganisers O\nsaid O\nthe O\nexact O\ntimetable O\nremained O\nunclear O\nbut O\nit O\nwould O\nprobably O\ntake O\nabout O\na O\nmonth O\nto O\norganise O\nan O\nelectoral O\ncollege O\nwhich O\ncould O\nalso O\nhold O\nseveral O\nrounds O\nof O\nvoting O\nbefore O\na O\nclear O\nwinner O\nemerges O\n. O\n\n-DOCSTART- O\n\nEstonia B-LOC\nassembly O\nfails O\nto O\nelect O\nstate O\npresident O\n. O\n\nTALLINN B-LOC\n1996-08-27 O\n\nThe O\nEstonian B-MISC\nparliament O\nfailed O\nfor O\na O\nthird O\nand O\nfinal O\ntime O\nto O\nelect O\na O\nnew O\nstate O\npresident O\non O\nTuesday O\n, O\nrefusing O\na O\nsecond O\nmandate O\nfor O\nincumbent O\nLennart B-PER\nMeri I-PER\n. O\n\nNeither O\nMeri B-PER\nnor O\nhis O\nrival O\nArnold B-PER\nRuutel I-PER\ncould O\ngarner O\nthe O\n68 O\nvotes O\nneeded O\nfrom O\nthe O\n101 O\nmembers O\nof O\nparliament O\nto O\nbecome O\npresident O\n. O\n\nIn O\nthe O\nthird O\nvote O\nMeri B-PER\nwon O\n52 O\nand O\nRuutel B-PER\nwon O\n32 O\nvotes O\n. O\n\nThe O\nfinal O\ndecision O\nwill O\nnow O\nbe O\nmade O\nby O\na O\nlarger O\nassembly O\n. O\n\nMeri B-PER\nwon O\n49 O\nin O\na O\nsecond O\nvote O\nearlier O\non O\nTuesday O\nand O\n45 O\nin O\nthe O\nfirst O\non O\nMonday O\n. O\n\nRuutel B-PER\nwon O\n34 O\nvotes O\nin O\nthe O\nfirst O\ntwo O\nsecret O\nballots O\n. O\n\nEnn B-PER\nMarkvart I-PER\n, O\nchairman O\nof O\nthe O\nNational B-ORG\nElection I-ORG\nCommission I-ORG\nsaid O\n96 O\nmembers O\nof O\nparliament O\ncast O\nvotes O\n, O\nwith O\none O\nballot O\npaper O\ninvalid O\nand O\n11 O\nabstentions O\n. O\n\nThe O\nelection O\nwill O\nnow O\ngo O\nbefore O\nan O\nelectoral O\ncollege O\ninvolving O\nMPs O\nand O\nlocal O\ngovernment O\nrepresentatives O\nthat O\nwill O\nbe O\nconvened O\nby O\nthe O\nparliamentary O\nSpeaker O\nin O\nthe O\nnext O\nday O\nor O\nso O\n. O\n\nIt O\ncould O\ntake O\nup O\nto O\na O\nmonth O\nbefore O\na O\nnew O\nvote O\nbut O\nthe O\ntimetable O\nis O\nnot O\nyet O\nclear O\n. O\n\nThis O\nis O\nthe O\nfirst O\ntime O\nthe O\nformer O\nSoviet B-MISC\nrepublic O\nhas O\nhad O\nto O\nconvene O\nsuch O\na O\ngroup O\n. O\n\n-DOCSTART- O\n\nAlbania B-LOC\ncharges O\nBriton B-MISC\nwith O\nchild O\nsex O\nabuse O\n. O\n\nTIRANA B-LOC\n1996-08-27 O\n\nAlbanian B-MISC\nauthorities O\nhave O\narrested O\nand O\ncharged O\na O\nBritish B-MISC\nman O\nfor O\nsexually O\nabusing O\ntwo O\nyoung O\nboys O\n, O\na O\nTirana B-LOC\nprosecutor O\nsaid O\non O\nTuesday O\n. O\n\n\" O\nWe O\nhave O\narrested O\nhim O\nand O\ncharged O\nhim O\nwith O\nthese O\nshameful O\nacts O\nof O\nsex O\nabuse O\nof O\nlittle O\nchildren O\n, O\n\" O\nprosecutor O\nAdnan B-PER\nXhelili I-PER\ntold O\nReuters B-ORG\n. O\n\nXhelili B-PER\nsaid O\nPaul B-PER\nThompson I-PER\n, O\n34 O\n, O\nfrom O\nWiltshire B-LOC\n, O\nwas O\narrested O\non O\nSunday O\nin O\na O\nhotel O\nin O\nthe O\nAdriatic B-MISC\nresort O\nof O\nDurres B-LOC\n, O\n45 O\nkm O\n( O\n30 O\nmiles O\n) O\nwest O\nof O\nTirana B-LOC\n. O\n\nThompson B-PER\nhas O\ndenied O\nthe O\ncharges O\n. O\n\nHe O\ncould O\nface O\nup O\nto O\nfive O\nyears O\nin O\njail O\nif O\nconvicted O\n. O\n\nXhelili B-PER\nsaid O\nThompson B-PER\n, O\nwho O\nis O\ndivorced O\n, O\nsaid O\nhe O\nbefriended O\nthe O\nboys O\n, O\nboth O\naged O\nunder O\n10 O\n, O\nbecause O\nthey O\nreminded O\nhim O\nof O\nhis O\nown O\nchildren O\nwho O\nlive O\nwith O\nhis O\nformer O\nwife O\nin O\nLondon B-LOC\n. O\n\nThe O\nprosecutor O\n's O\noffice O\nsaid O\nno O\ndate O\nhad O\nyet O\nbeen O\nset O\nfor O\na O\ntrial O\nto O\nbegin O\nas O\ninvestigations O\nhad O\nfirst O\nto O\nbe O\ncompleted O\n. O\n\nThe O\nBritish B-MISC\nembassy O\nin O\nTirana B-LOC\nsaid O\nit O\nhad O\nsent O\nan O\nembassy O\nofficial O\nto O\ntalk O\nto O\nThompson B-PER\nwho O\nis O\nbeing O\nheld O\nin O\njail O\n. O\n\nThe O\nage O\nof O\nconsent O\nfor O\nheterosexual O\nand O\nhomosexual O\nsex O\nin O\nAlbania B-LOC\nis O\n14 O\n. O\n\nA O\nlarge O\nnumber O\nof O\ndestitute O\nchildren O\ncan O\nbe O\nseen O\nbegging O\nin O\nthe O\nstreets O\nof O\nimpoverished O\nAlbania B-LOC\n, O\nespecially O\nin O\ntowns O\nand O\nresorts O\nvisited O\nby O\nforeigners O\n. O\n\n-DOCSTART- O\n\nEstonia B-LOC\nassembly O\nagain O\nfails O\nto O\nelect O\npresident O\n. O\n\nTALLINN B-LOC\n1996-08-27 O\n\nEstonia B-LOC\n's O\nparliament O\nagain O\nfailed O\nto O\nelect O\na O\nnew O\nstate O\npresident O\non O\nTuesday O\nwhen O\nneither O\nof O\ntwo O\ncandidates O\nsecured O\na O\nmajority O\nin O\nsecond-round O\nvoting O\n. O\n\nIncumbent O\npresident O\nLennart B-PER\nMeri I-PER\nwon O\n49 O\nvotes O\ncompared O\nto O\n34 O\nwon O\nby O\nhis O\nrival O\n, O\ndeputy O\nParliamentary O\nSpeaker O\nArnold B-PER\nRuutel I-PER\n. O\n\nBut O\nMeri B-PER\n's O\nsupport O\nwas O\nnot O\nenough O\nfor O\nthe O\n68 O\nneeded O\nfor O\nelection O\nand O\na O\nthird O\nsecret O\nballot O\nwill O\ntake O\nplace O\nlater O\nin O\nthe O\nday O\n( O\n1300 O\nGMT B-MISC\n) O\n, O\nparliamentary O\nofficials O\nsaid O\n. O\n\nTo O\nwin O\na O\nclear O\nmandate O\nfor O\nthe O\nfive-year O\npresidential O\nterm O\n, O\na O\ncandidate O\nmust O\nsecure O\n68 O\nvotes O\nfrom O\nthe O\n101-member O\nparliament O\n. O\n\nEnn B-PER\nMarkvart I-PER\n, O\nChairman O\nof O\nthe O\nNational B-ORG\nElection I-ORG\nCommission I-ORG\n, O\nsaid O\n96 O\nmembers O\nof O\nparliament O\nvoted O\nin O\nthe O\nsecond O\nround O\n, O\nwith O\n12 O\nabstentions O\nand O\none O\nballot O\npaper O\ninvalid O\n. O\n\nOn O\nMonday O\n, O\nin O\nthe O\nfirst O\nround O\nof O\nvoting O\n, O\nMeri B-PER\nsecured O\n45 O\nvotes O\nand O\nRuutel B-PER\n34 O\n. O\n\nMeri B-PER\n's O\npopularity O\nhas O\nsuffered O\nin O\nrecent O\nyears O\n, O\nwith O\npoliticians O\ncriticising O\nhim O\nfor O\ntaking O\ntoo O\nmuch O\npower O\nand O\nacting O\nwithout O\nconsulting O\nparliament O\n. O\n\nIf O\na O\nthird O\nround O\nof O\nvoting O\nfails O\nto O\ngive O\neither O\ncandidate O\n68 O\nvotes O\n, O\nthe O\nparliamentary O\nspeaker O\nhas O\nto O\nconvene O\nan O\nelectoral O\ncollege O\nof O\nall O\n101 O\nMPs O\nand O\n273 O\nlocal O\ngovernment O\nrepresentatives O\nfor O\na O\nnew O\nvote O\nthat O\ncould O\ntake O\nup O\nto O\na O\nmonth O\n. O\n\n-DOCSTART- O\n\nSlovak B-MISC\nwomen O\nvisited O\nDutroux B-PER\n, O\npolice O\nsay O\n. O\n\nPeter B-PER\nLaca I-PER\n\nBRATISLAVA B-LOC\n1996-08-27 O\n\nMarc B-PER\nDutroux I-PER\n, O\nthe O\nchief O\naccused O\nin O\nBelgium B-LOC\n's O\nsensational O\nchild O\nmurder O\nand O\nsex O\nabuse O\ncase O\n, O\nvisited O\nSlovakia B-LOC\na O\nnumber O\nof O\ntimes O\nand O\nabout O\n10 O\nyoung O\nSlovak B-MISC\nwomen O\nwent O\nto O\nBelgium B-LOC\nat O\nhis O\ninvitation O\n, O\npolice O\nsaid O\non O\nTuesday O\n. O\n\nBut O\nthey O\nhave O\ndifficulty O\nremembering O\nwhat O\nhappened O\nthere O\n, O\nperhaps O\nbecause O\nof O\ndrugs O\n, O\nand O\nare O\nunsure O\nwhether O\nthey O\nwere O\nfilmed O\nfor O\npornography O\n, O\nRudolf B-PER\nGajdos I-PER\n, O\nhead O\nof O\nthe O\nSlovak B-MISC\noffice O\nof O\nInterpol B-ORG\n, O\ntold O\nReuters B-ORG\n. O\n\nAlthough O\nGajdos B-PER\nspoke O\nof O\n\" O\ngirls O\n\" O\nhis O\ndeputy O\n, O\nEva B-PER\nBoudova I-PER\n, O\nsaid O\nthe O\ncase O\ninvolved O\nabout O\n10 O\nyoung O\nwomen O\nin O\ntheir O\nearly O\n20s O\n. O\n\n\" O\nThe O\npolice O\ninterrogated O\nseveral O\nSlovak B-MISC\ngirls O\nwho O\nsaid O\nthat O\nthey O\nhad O\nbeen O\ninvited O\nby O\nMark B-PER\nDutroux I-PER\nto O\nvisit O\nBelgium B-LOC\n, O\n\" O\nGajdos B-PER\nsaid O\n. O\n\n\" O\nThe O\ngirls O\nsaid O\nthey O\nwent O\nto O\nBelgium B-LOC\nvoluntarily O\nand O\nthe O\npolice O\nsuspect O\nthat O\nthey O\nwere O\nused O\nto O\nact O\nin O\npornographic O\nfilms O\n. O\n\" O\n\n\" O\nThe O\npolice O\nsuspect O\n( O\nthe O\ngirls O\n) O\nwere O\nunder O\nthe O\ninfluence O\nof O\ndrugs O\nas O\nsome O\ngirls O\nadmitted O\nthey O\ntook O\nunspecified O\npills O\n. O\n\" O\n\n\" O\nWe O\nhave O\nsuspicions O\nof O\na O\nrape O\n, O\nbut O\nthe O\npolice O\nstill O\nhave O\nto O\nfind O\nthe O\nvictim O\n, O\n\" O\nGajdos B-PER\nadded O\n. O\n\nDutroux B-PER\n's O\nlast O\nvisit O\nto O\nSlovakia B-LOC\nwas O\nreported O\nto O\nhave O\nbeen O\nas O\nrecent O\nas O\nJuly O\n. O\n\nSlovak B-MISC\npolice O\nare O\nalso O\ncooperating O\nwith O\nBelgium B-LOC\nin O\nthe O\nsearch O\nfor O\nAn B-PER\nMarchal I-PER\nand O\nEefje B-PER\nLambrecks I-PER\n, O\nwho O\nwent O\nmissing O\nlast O\nAugust O\n. O\n\nDutroux B-PER\n, O\n39 O\n, O\nwho O\nwas O\ncharged O\nlast O\nweek O\nwith O\nthe O\nabduction O\nand O\nillegal O\nimprisonment O\nof O\ntwo O\nother O\ngirls O\naged O\n14 O\nand O\n12 O\n, O\nis O\none O\nof O\nseveral O\nsuspects O\nin O\nthe O\nMarchal B-PER\nand O\nLambrecks B-PER\ncase O\n. O\n\nLast O\nSaturday O\nhe O\nled O\npolice O\nto O\nthe O\nbodies O\nof O\ntwo O\nother O\ngirls O\n, O\naged O\neight O\n, O\nwho O\ndied O\nof O\nstarvation O\nthis O\nyear O\nafter O\ntheir O\nabduction O\nin O\nJune O\n, O\n1995 O\n. O\n\nThe O\nCzech B-MISC\noffice O\nof O\nInterpol B-ORG\nsaid O\non O\nFriday O\nit O\nwould O\nneither O\nconfirm O\nnor O\ndeny O\nthat O\nDutroux B-PER\nhad O\nbeen O\nin O\nthe O\nCzech B-LOC\nRepublic I-LOC\n, O\nSlovakia B-LOC\n's O\nwestern O\nneighbour O\nand O\nformer O\nfederation O\npartner O\n. O\n\nBelgian B-MISC\npolice O\nsaid O\nan O\nofficer O\nhad O\nvisited O\nBratislava B-LOC\nto O\ntalk O\nwith O\nSlovak B-MISC\ndetectives O\nabout O\nAn B-PER\nand O\nEefje B-PER\nand O\nother O\ndisappearances O\n, O\nand O\nhe O\nplanned O\nto O\ngo O\nalso O\nto O\nPrague B-LOC\n. O\n\n-DOCSTART- O\n\nWEATHER O\n- O\nConditions O\nat O\nCIS B-LOC\nairports O\n- O\nAugust O\n27 O\n. O\n\nMOSCOW B-LOC\n1996-08-27 O\n\nNo O\nclosures O\nof O\nairports O\ndue O\nto O\nbad O\nweather O\nare O\nexpected O\nin O\nthe O\nCommonwealth B-LOC\nof I-LOC\nIndependent I-LOC\nStates I-LOC\non O\nAugust O\n28 O\nand O\nAugust O\n29 O\n, O\nthe O\nRussian B-ORG\nWeather I-ORG\nService I-ORG\nsaid O\non O\nTuesday O\n. O\n\n-- O\nMoscow B-ORG\nNewsroom I-ORG\n+7095 O\n941 O\n8520 O\n\n-DOCSTART- O\n\nRussian B-MISC\nserial O\nkiller O\nstrikes O\nagain O\n. O\n\nMOSCOW B-LOC\n1996-08-27 O\n\nRussian B-MISC\npolice O\nin O\nthe O\nUrals B-MISC\ncity O\nof O\nPerm B-LOC\nare O\non O\nthe O\ntrail O\nof O\na O\nserial O\nkiller O\nwho O\nhas O\nclaimed O\nhis O\nseventh O\nvictim O\nin O\njust O\na O\nfew O\nmonths O\n, O\nItar-Tass B-ORG\nnews O\nagency O\nsaid O\non O\nTuesday O\n. O\n\nIn O\nthe O\nlatest O\nattack O\n, O\nthe O\nkiller O\nraped O\nand O\nstabbed O\na O\nyoung O\nwoman O\nin O\na O\nlift O\n, O\nleaving O\nher O\nbody O\non O\na O\nlanding O\n. O\n\nTass B-ORG\ndid O\nnot O\nsay O\nexactly O\nwhen O\nit O\ntook O\nplace O\n. O\n\nPolice O\nearlier O\nreleased O\na O\nsuspect O\nafter O\nwomen O\nwho O\nhad O\nsurvived O\nan O\nattack O\nfailed O\nto O\nidentify O\nhim O\n. O\n\n-DOCSTART- O\n\nRussian B-MISC\narmy O\n, O\nChechens B-MISC\nopen O\nnew O\nround O\nof O\ntalks O\n. O\n\nMOSCOW B-LOC\n1996-08-27 O\n\nRussia B-LOC\n's O\nmilitary O\ncommander O\nin O\nChechnya B-LOC\nbegan O\nnew O\ntalks O\nwith O\nseparatist O\nchief-of-staff O\nAslan B-PER\nMaskhadov I-PER\non O\nTuesday O\n, O\nItar-Tass B-ORG\nnews O\nagency O\nsaid O\n. O\n\nTass B-ORG\nsaid O\nthe O\ntalks O\nwere O\ntaking O\nplace O\nin O\nthe O\nsettlement O\nof O\nNovye B-LOC\nAtagi I-LOC\n, O\nsome O\n20 O\nkm O\n( O\n12 O\nmiles O\n) O\nsouth O\nof O\nthe O\nChechen B-MISC\ncapital O\nGrozny B-LOC\n. O\n\nThe O\ntalks O\nhad O\nbeen O\npostponed O\nwhile O\nthe O\nRussians B-MISC\nwaited O\nfor O\nthe O\nrebels O\nto O\nreturn O\narms O\nand O\nammunition O\nseized O\nfrom O\nRussian B-MISC\nsoldiers O\nat O\nthe O\nweekend O\n. O\n\nThe O\nChechens B-MISC\nsaid O\non O\nMonday O\nthey O\nhad O\nreturned O\nall O\nthe O\nweapons O\n, O\nwhich O\nthey O\nsaid O\nwere O\nseized O\nby O\na O\nrenegade O\ngroup O\n. O\n\nThe O\ntalks O\nbetween O\nMaskhadov B-PER\nand O\nRussia B-LOC\n's O\nVyacheslav B-PER\nTikhomirov I-PER\nare O\naimed O\nat O\nputting O\nthe O\nfinishing O\ntouches O\nto O\na O\nceasefire O\nsealed O\nlast O\nweek O\nin O\ntalks O\nwith O\nRussian B-MISC\nsecurity O\nchief O\nAlexander B-PER\nLebed I-PER\n. O\n\nLebed B-PER\n, O\nwho O\nmet O\nRussian B-MISC\nPrime O\nMinister O\nViktor B-PER\nChernomyrdin I-PER\non O\nMonday O\nto O\ndiscuss O\nthe O\nprogress O\nhe O\nmade O\non O\na O\npolitical O\nsettlement O\nfor O\nthe O\nbreakaway O\nregion O\n, O\nhas O\nbeen O\nseeking O\na O\nmeeting O\nwith O\nPresident O\nBoris B-PER\nYeltsin I-PER\n, O\nwho O\nstarted O\na O\nholiday O\nnear O\nMoscow B-LOC\non O\nMonday O\n. O\n\n-DOCSTART- O\n\nArgentine B-MISC\nbishop O\nreminds O\ncabinet O\nof O\nCommandments O\n. O\n\nBUENOS B-LOC\nAIRES I-LOC\n, O\nArgentina B-LOC\n1996-08-27 O\n\nThe O\nArchbishop O\nof O\nBuenos B-LOC\nAires I-LOC\nsaid O\non O\nTuesday O\nthe O\nfirst O\nthing O\nhe O\nwould O\ndo O\nif O\nelected O\npresident O\nof O\nArgentina B-LOC\nwould O\nbe O\nto O\nput O\nup O\nposters O\nof O\nthe O\nTen B-MISC\nCommandments I-MISC\nin O\ngovernment O\noffices O\n. O\n\n\" O\nThey O\nasked O\nme O\nwhat O\nwould O\nbe O\nthe O\nfirst O\nthing O\nI O\nwould O\ndo O\nif O\nI O\nwere O\npresident O\n, O\nand O\nI O\nsaid O\nthe O\nfirst O\nthing O\nI O\nwould O\ndo O\nwould O\nbe O\nto O\nresign O\nstraight O\naway O\n, O\n\" O\nArchbishop O\nAntonio B-PER\nQuarracino I-PER\nsaid O\nat O\na O\nsermon O\nattended O\nby O\nseveral O\ncabinet O\nministers O\n. O\n\n\" O\nBut O\nbefore O\ngoing O\n, O\nI O\nwould O\nhave O\nbig O\nsigns O\nput O\nup O\nin O\nall O\ngovernment O\noffices O\n, O\nthose O\nto O\ndo O\nwith O\njustice O\n, O\nin O\nall O\nsectors O\n, O\nwith O\nthe O\nTen B-MISC\nCommandments I-MISC\n, O\n\" O\nhe O\nadded O\n. O\n\nArgentina B-LOC\n's O\ntop O\nRoman B-MISC\nCatholic I-MISC\ncleric O\nsaid O\nthe O\nBiblical B-MISC\ncommandment O\n\" O\nThou O\nshalt O\nnot O\nsteal O\n\" O\nwould O\nget O\nspecial O\nemphasis O\n\" O\nbecause O\nit O\nhas O\nto O\nbe O\nabout O\nthe O\nmost O\ncommon O\nthing O\nthese O\ndays O\n. O\n\" O\n\nQuarracino B-PER\nand O\nother O\nChurch O\nleaders O\nare O\nregular O\ncritics O\nof O\nthe O\ngovernment O\n's O\nfree-market O\neconomic O\npolicy O\n. O\n\n-DOCSTART- O\n\nBrazil B-LOC\n's O\nEletropaulo B-ORG\nnames O\nnew O\npresident O\n. O\n\nSAO B-PER\nPAULO I-PER\n1996-08-27 O\n\nSao B-LOC\nPaulo I-LOC\nstate O\npower O\nfirm O\nEletropaulo B-ORG\nsaid O\nit O\nhas O\nnamed O\nEduardo B-PER\nBernini I-PER\nas O\nnew O\npresident O\n, O\nreplacing O\nEmmanuel B-PER\nSobral I-PER\n, O\nwho O\nwill O\nhead O\na O\nsecretariat O\nat O\nthe O\nTransportation B-ORG\nMinistry I-ORG\n. O\n\nBernini B-PER\nis O\nexpected O\nto O\ntake O\noffice O\nThursday O\n, O\na O\nEletropaulo B-ORG\nspokeswoman O\nsaid O\n. O\n\n-- O\nRomina B-PER\nNicaretta I-PER\n, O\nSao B-LOC\nPaulo I-LOC\nnewsroom O\n, O\n5511 O\n232 O\n4411 O\n. O\n\n-DOCSTART- O\n\nDutch B-MISC\ngovernment O\nwo O\nn't O\npay O\nransom O\nfor O\nkidnap O\nvictims O\n. O\n\nSAN B-LOC\nJOSE I-LOC\n, O\nCosta B-LOC\nRica I-LOC\n1996-08-27 O\n\nThe B-LOC\nNetherlands I-LOC\ngovernment O\nhas O\nruled O\nout O\npaying O\nransom O\nmoney O\nfor O\na O\nDutch B-MISC\ncouple O\nkidnapped O\nfrom O\ntheir O\nfarm O\n, O\nwhile O\nCosta B-MISC\nRican I-MISC\nauthorities O\nsaid O\non O\nTuesday O\nthey O\nhad O\nno O\nleads O\nin O\nthe O\ncase O\n. O\n\n\" O\nWe O\nhave O\nnot O\nhad O\ncontact O\nwith O\nthe O\nkidnappers O\nnor O\ndo O\nwe O\nhave O\nany O\nleads O\nto O\ntake O\nus O\nto O\nwhere O\nthey O\nmight O\nbe O\nheld O\n, O\n\" O\nChief O\nof O\nJudicial B-ORG\nPolice I-ORG\nManuel B-PER\nAlvarado I-PER\ntold O\nReuters B-ORG\n. O\n\nHurte B-PER\nSierd I-PER\nZylstra I-PER\nand O\nhis O\nwife O\n, O\nJetsi B-PER\nHendrika I-PER\nCoers I-PER\n, O\nboth O\n50 O\n, O\nwere O\nabducted O\nfrom O\nthe O\nteak O\nplantation O\nthey O\nmanaged O\nlate O\nSaturday O\nor O\nearly O\nSunday O\nby O\nat O\nleast O\ntwo O\nmen O\ndemanding O\n$ O\n1.5 O\nmillion O\nransom O\n, O\nauthorities O\nsaid O\n. O\n\nCosta B-MISC\nRican I-MISC\nofficials O\non O\nMonday O\nhad O\ngiven O\ndifferent O\nnames O\nfor O\nthe O\ncouple O\n. O\n\nAnton B-PER\nSchutte I-PER\n, O\nan O\nofficial O\nwith O\nthe O\nembassy O\nfor O\nBelgium B-LOC\n, O\nthe O\nNetherlands B-LOC\nand O\nLuxembourg B-LOC\n, O\nsaid O\nthe O\nDutch B-MISC\ngovernment O\nhad O\nruled O\nout O\npaying O\nany O\nmoney O\nin O\nransom O\n. O\n\" O\n\nWe O\n're O\nlooking O\nat O\na O\ncriminal O\nact O\nthat O\nhas O\nno O\npolitical O\naspect O\nas O\nfar O\nas O\nwhat O\nwe O\ncan O\ntell O\n, O\n\" O\nSchutte B-PER\nadded O\n. O\n\nA O\nnote O\nwith O\nthe O\nransom O\ndemand O\nwas O\nleft O\nin O\nthe O\ncouple O\n's O\ncar O\n, O\nwhich O\nwas O\nused O\nin O\nthe O\nkidnapping O\n, O\nSchutte B-PER\ntold O\na O\nnews O\nconference O\non O\nMonday O\n. O\n\nHe O\nsaid O\nthe O\nnote O\n, O\nbelieved O\nto O\nhave O\nbeen O\nhand-written O\nin O\nSpanish B-MISC\nand O\nsigned O\nby O\nthe O\nvictims O\n, O\nwas O\naddressed O\nto O\nEbe B-PER\nHuizinga I-PER\n, O\nanother O\nDutch B-MISC\ncitizen O\nwho O\nowns O\nthe O\ntree O\nplantation O\n. O\n\" O\n\nDepending O\non O\nyou O\n, O\nwe O\nwill O\neither O\nlive O\nor O\ndie O\n, O\n\" O\nit O\nsaid O\n. O\n\nAlvarado B-PER\nsaid O\nthe O\ncar O\nwas O\nabandoned O\nabout O\n40 O\nmiles O\n( O\n60 O\nkm O\n) O\nnorth O\nof O\nthe O\ncouple O\n's O\nhouse O\nbut O\nsaid O\nthat O\ndid O\nnot O\nindicate O\nthe O\nkidnappers O\nintended O\nto O\ntake O\ntheir O\nvictims O\ninto O\nneighbouring O\nNicaragua B-LOC\n. O\n\nThe O\nfarm O\nis O\nin O\nthe O\nborder O\nregion O\nwhere O\na O\nGerman B-MISC\ntourist O\nand O\na O\nSwiss B-MISC\ntour O\nguide O\nwere O\nkidnapped O\nlast O\nNew O\nYear O\n's O\nEve O\nby O\na O\nheavily O\narmed O\nband O\nled O\nby O\na O\nformer O\nNicaraguan B-MISC\nguerrilla O\n. O\n\nThe O\ntwo O\nwere O\nheld O\nfor O\n71 O\ndays O\nuntil O\nrelatives O\npaid O\na O\nransom O\n. O\n\nTwo O\nof O\nthe O\nsuspected O\nabductors O\nhave O\nsince O\nbeen O\narrested O\n. O\n\n-DOCSTART- O\n\nVenezuela B-LOC\nunions O\nharden O\ntowards O\nCVG B-ORG\nprivatization O\n. O\n\nCARACAS B-LOC\n1996-08-27 O\n\nA O\nswell O\nof O\nprotest O\nis O\ngrowing O\nwithin O\nVenezuela B-LOC\n's O\ntrade O\nunions O\nat O\nthe O\nproposed O\nyear-end O\nprivatization O\nof O\nthe O\nstate-owned O\nholding O\ncompany O\nCorporacion B-ORG\nVenezolana I-ORG\nde I-ORG\nGuayana I-ORG\n( O\nCVG B-ORG\n) O\n, O\nCVG B-ORG\nunion O\nleaders O\nsaid O\nTuesday O\n. O\n\n\" O\nWe O\noppose O\nthe O\nway O\nthe O\ngovernment O\nis O\nproceeding O\nwith O\nthe O\nsale O\n, O\n\" O\nRamon B-PER\nMachuca I-PER\n, O\nSidor B-ORG\ntrade O\nunion O\nSecretary O\nGeneral O\nand O\nmember O\nof O\nunion-based O\nopposition O\nparty O\nRadical B-ORG\nCause I-ORG\n, O\ntold O\nreporters O\n. O\n\n\" O\nWe O\ndo O\nn't O\nbelieve O\nthe O\ngovernment O\nwill O\nmake O\nits O\ntimetable O\n, O\n\" O\nhe O\nadded O\n. O\n\nSidor B-ORG\nis O\nthe O\nCVG B-ORG\n's O\nsteel-producing O\narm O\n, O\nslated O\nfor O\na O\nDecember O\nsale O\nworth O\nan O\nestimated O\n$ O\n1.5 O\nbillion O\n. O\n\nThe O\nCVG B-ORG\n's O\naluminum O\ncompanies O\nVenalum B-ORG\nand O\nAlucasa B-ORG\nare O\nalso O\nscheduled O\nto O\nbe O\nsold O\nearly O\n1997 O\n. O\n\nArguing O\nthat O\nCVG B-ORG\n's O\nprivatization O\nwould O\nresult O\nin O\nsome O\n13,000 O\nlayoffs O\n, O\ncompared O\nto O\nthe O\ngovernment O\n's O\nestimated O\n1,500 O\n, O\nCVG B-ORG\n's O\nunion O\nleaders O\ntold O\nreporters O\nthey O\nwould O\nstrike O\nand O\nstage O\nprotests O\nif O\ntheir O\nconcerns O\nwere O\nnot O\naddressed O\n. O\n\n\" O\nWe O\noppose O\nany O\nprivatization O\nthat O\nhurts O\nworkers O\n' O\nwelfare O\nand O\ndoes O\nnot O\ntake O\ninto O\naccount O\nits O\nsocial O\nimpact O\n, O\n\" O\nthey O\nsaid O\n. O\n\nThe O\nopposition O\nparty O\nRadical B-ORG\nCause I-ORG\ncontrols O\nall O\nof O\nthe O\nunionized O\nworkers O\nat O\nthe O\nCVG B-ORG\nheavy O\nindustry O\ncomplex O\nand O\nhas O\nsystematically O\nopposed O\nall O\ngovernment O\nlegislation O\nin O\ncongress O\n. O\n\n-- O\nOmar B-PER\nLugo I-PER\n, O\nCaracas B-LOC\nnewsroom O\n, O\n582 O\n834405 O\n\n-DOCSTART- O\n\nNicaraguan B-MISC\ndrunks O\nfear O\n\" O\nlovebite O\n\" O\nbandit O\n. O\n\nMANAGUA B-LOC\n, O\nNicaragua B-LOC\n1996-08-27 O\n\nHeavy O\ndrinkers O\nin O\na O\nNicaraguan B-MISC\ncity O\nwere O\nsearching O\nfor O\nsomeone O\nwho O\nhas O\ncovered O\nthem O\nin O\n\" O\nlovebites O\n\" O\nwhile O\nthey O\nwere O\npassed O\nout O\nin O\na O\ndrunken O\nstupor O\n, O\na O\nlocal O\nnewspaper O\nreported O\non O\nTuesday O\n. O\n\nThe O\ndreaded O\n\" O\nchupabolos O\n\" O\n-- O\n\" O\ndrunksucker O\n\" O\n-- O\npreys O\non O\nmen O\nwho O\nhave O\npassed O\nout O\nin O\nthe O\nstreets O\nof O\nMatagalpa B-LOC\n, O\n80 O\nmiles O\n( O\n130 O\nkms O\n) O\nnorth O\nof O\nManagua B-LOC\n, O\nplacing O\nhickey-like O\n\" O\nlovebites O\n\" O\non O\nvarious O\nparts O\nof O\ntheir O\nbodies O\n, O\nEl B-ORG\nNuevo I-ORG\nDiario I-ORG\nreported O\n. O\n\nEnraged O\ndrunks O\nand O\nstreet O\npeople O\nin O\nthis O\ntown O\nknown O\nfor O\nits O\nmachismo O\nhave O\norganised O\na O\nso-far O\nunsuccessful O\nsearch O\nfor O\nthe O\nculprit O\nwho O\nfinds O\nvictims O\nin O\nthe O\ndark O\nstreets O\nsurrounding O\na O\nlocal O\nmarket O\n. O\n\nThe O\ntotal O\nnumber O\nof O\nvictims O\nwas O\nstill O\nunknown O\n. O\n\nThe O\nfirst O\nof O\nthe O\nvictims O\nwere O\ntwo O\nvagrants O\nwho O\nslept O\nin O\nan O\nabandoned O\ncar O\nin O\nfront O\nof O\na O\nlocal O\nbank O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nIn O\nspite O\nof O\nthe O\ncollective O\nfear O\ngripping O\nMatagalpa B-LOC\n's O\ndrinkers O\n, O\nlocal O\nwomen O\nexpressed O\nlittle O\nsympathy O\n. O\n\n\" O\nIts O\njust O\ndesserts O\nfor O\nall O\nthe O\n' O\nbolos O\n' O\n( O\ndrunkards O\n) O\nwho O\nsleep O\nin O\nthe O\nstreets O\nof O\nour O\nbeautiful O\ntown O\n, O\n\" O\nsaid O\na O\nwoman O\nwho O\nworked O\nin O\nthe O\nlocal O\nmarket O\n. O\n\n-DOCSTART- O\n\nBrazil B-LOC\nlikely O\nto O\nturn O\nBanespa B-ORG\nfederal O\nbank O\n- O\npaper O\n. O\n\nSAO B-PER\nPAULO I-PER\n1996-08-27 O\n\nBrazil B-LOC\nis O\nlikely O\nto O\nturn O\nSao B-LOC\nPaulo I-LOC\nstate O\nbank O\nBanespa B-ORG\ninto O\na O\nfederal O\nbank O\nin O\na O\nprior O\nstep O\nto O\nprivatization O\n, O\naccording O\nto O\nunnamed O\ngovernment O\nsources O\n, O\nO B-ORG\nGlobo I-ORG\ndaily O\nsaid O\n. O\n\nThe O\nnewspaper O\nsaid O\nthe O\nCentral B-ORG\nBank I-ORG\nspecial O\nadministration O\nof O\nBanespa B-ORG\nends O\nin O\nDecember O\n30 O\nand O\nafter O\nthat O\nthe O\nbank O\nhas O\nto O\nbe O\nliquidated O\nor O\nturned O\ninto O\na O\nfederal O\nbank O\nsince O\nthere O\nare O\nno O\nconditions O\nto O\nreturn O\nBanespa B-ORG\nto O\nSao B-LOC\nPaulo I-LOC\nstate O\ngovernment O\n. O\n\nA O\nCentral B-ORG\nBank I-ORG\nspokesman O\nsaid O\nhe O\ncould O\nnot O\nconfirm O\nor O\ndeny O\nthe O\nreport O\n. O\n\nBanespa B-ORG\nhas O\nbeen O\nunder O\ncentral O\nbank O\nspecial O\ntemporary O\nadministration O\nsince O\nDecember O\n1994 O\n. O\n\nThe O\ncentral O\nbank O\nmanagement O\ncould O\nbe O\nlifted O\nif O\nSao B-LOC\nPaulo I-LOC\nstate O\ndecided O\nto O\ntake O\npart O\nin O\nthe O\nrecent O\nfederal O\ngovernment O\n's O\nplan O\nto O\nrestructure O\nstate O\nbanks O\n. O\n\nUnder O\nthe O\nplan O\n, O\nthe O\nfederal O\ngovernment O\nwould O\nprovide O\n100 O\npercent O\nof O\nthe O\nfinancing O\nneeded O\nto O\nrestructure O\ndebt O\nof O\nstate O\nbanks O\nbeing O\nprivatized O\n, O\nliquidated O\nor O\nturned O\ninto O\ndevelopment O\nbanks O\n. O\n\nIt O\nalso O\noffers O\nto O\nrefinance O\nup O\nto O\n50 O\npercent O\nof O\nthe O\ndebt O\nheld O\nby O\nstate O\nbanks O\nwhose O\ngovernments O\ndecide O\nto O\nkeep O\ncontrol O\nof O\ntheir O\nbanks O\n. O\n\nAlthough O\nthe O\nplan O\nwas O\ndesigned O\nunder O\nterms O\nproposed O\nby O\nSao B-LOC\nPaulo I-LOC\nstate O\ngovernor O\nMario B-PER\nCovas I-PER\n, O\nhe O\nhas O\nshowed O\nno O\ninterest O\nin O\ntaking O\npart O\nin O\nthe O\nplan O\nbecause O\nSao B-LOC\nPaulo I-LOC\n's O\ndebt O\nwith O\nBanespa B-ORG\nhas O\nincreased O\nsharply O\n, O\nO B-ORG\nGlobo I-ORG\nsaid O\n. O\n\nSao B-LOC\nPaulo I-LOC\nstate O\n's O\ndebt O\nis O\nnow O\nestimated O\nat O\n19 O\nbillion O\nreais O\n. O\n\nO B-ORG\nGlobo I-ORG\nalso O\nsaid O\nanother O\ndelicate O\ncase O\nto O\nbe O\nsolved O\ninvolves O\nprivate O\nbank O\nBamerindus B-ORG\n. O\n\nThe O\nnewspaper O\nsaid O\nBamerindus B-ORG\nhas O\nsent O\nto O\nthe O\nCentral B-ORG\nBank I-ORG\na O\nproposal O\nfor O\nrestructuring O\ncombined O\nwith O\na O\nrequest O\nfor O\na O\n90-day O\ncredit O\nline O\n, O\npaying O\nfour O\npercent O\na O\nyear O\nplus O\nthe O\nBasic O\nInterest O\nRate O\nof O\nthe O\nCentral B-ORG\nBank I-ORG\n( O\nTBC B-ORG\n) O\n. O\n\nO B-ORG\nGlobo I-ORG\nalso O\nsaid O\nthe O\nloan O\nwould O\ngive O\nBamerindus B-ORG\ntime O\nto O\nsell O\nassets O\n. O\n\nBamerindus B-ORG\n, O\nBrazil B-LOC\n's O\nfourth-largest O\nprivate O\nbank O\n, O\nhas O\nbeen O\nfacing O\nliquidity O\ntroubles O\n. O\n\nBamerindus B-ORG\ndeclined O\nto O\ncomment O\non O\nnegotiations O\nbeing O\nheld O\nwith O\nthe O\nCentral B-ORG\nBank I-ORG\n. O\n\n-- O\nFatima B-PER\nCristina I-PER\n, O\nSao B-LOC\nPaulo I-LOC\nnewsroom O\n, O\n55-11-2324411 O\n\n-DOCSTART- O\n\nCzech B-LOC\nRepublic I-LOC\n's O\nHavel B-PER\nto O\ntour O\nBrazil B-LOC\nin O\nSeptember O\n. O\n\nBRASILIA B-LOC\n1996-08-27 O\n\nCzech B-LOC\nRepublic I-LOC\nPresident O\nVaclav B-PER\nHavel I-PER\nis O\nscheduled O\nto O\nmake O\nan O\nofficial O\nvisit O\nto O\nBrazil B-LOC\nSept O\n. O\n\n15-21 O\n, O\nBrazil B-LOC\n's O\nForeign O\nRelations O\nMinistry O\nsaid O\non O\nTuesday O\n. O\n\nHavel B-PER\nis O\ndue O\nto O\nmeet O\nwith O\nhis O\nBrazilian B-MISC\ncounterpart O\nFernando B-PER\nHenrique I-PER\nCardoso I-PER\nin O\nthe O\ncapital O\nBrasilia B-LOC\nand O\nwill O\nvisit O\nthe O\ncities O\nof O\nManaus O\n, O\nSao B-LOC\nPaulo I-LOC\nand O\nRio B-LOC\nde I-LOC\nJaneiro I-LOC\n. O\n\nAlso O\ndue O\nto O\nvisit O\nBrazil B-LOC\nin O\nSeptember O\nare O\nSouth B-MISC\nKorean I-MISC\nPresident O\nKim B-PER\nYoung I-PER\nSam I-PER\nand O\nGerman B-MISC\nChancellor O\nHelmut B-PER\nKohl I-PER\n. O\n\n-DOCSTART- O\n\nFormer O\nArgentine B-MISC\nbenevolent O\ndictator O\nAlejandro B-PER\nLanusse I-PER\ndies O\n. O\n\nBUENOS B-LOC\nAIRES I-LOC\n1996-08-26 O\n\nAlejandro B-PER\nLanusse I-PER\n, O\nthe O\nformer O\ndictator O\nwho O\nruled O\nArgentina B-LOC\nfor O\ntwo O\nyears O\n, O\ndied O\nat O\nage O\n78 O\non O\nMonday O\n. O\n\nLanusse B-PER\ndied O\nafter O\nbeing O\nbrought O\nto O\na O\nhospital O\na O\nweek O\nago O\nfollowing O\na O\nfall O\nat O\nhome O\nthat O\nresulted O\nin O\na O\nblood O\nclot O\nin O\nthe O\nbrain O\n. O\n\nHe O\nwas O\noperated O\non O\nearlier O\nin O\nthe O\nweek O\nbut O\nfailed O\nto O\nrecover O\nfrom O\nsurgery O\n. O\n\nThe O\nformer O\ndictator O\n, O\nwho O\nruled O\nfrom O\n1971 O\nto O\n1973 O\n, O\nwas O\nbest O\nknown O\nfor O\nallowing O\nJuan B-PER\nDomingo I-PER\nPeron I-PER\n, O\nArgentina B-LOC\n's O\nfamed O\npopulist O\nleader O\n, O\nto O\nreturn O\nto O\nArgentina B-LOC\nafter O\n17 O\nyears O\nof O\nforced O\nexile O\n. O\n\nLanusse B-PER\ntook O\nover O\nthe O\nleadership O\nof O\nthe O\ncountry O\nafter O\nfive O\nyears O\nof O\ndictatorship O\n. O\n\nBut O\nunlike O\nhis O\ntwo O\npredecessors O\n, O\nJuan B-PER\nCarlos I-PER\nOngania O\nand O\nMarcelo B-PER\nLevingston I-PER\n, O\nwho O\nruled O\nArgentina B-LOC\nwith O\nan O\niron O\nhand O\n, O\nLanusse B-PER\nsteered O\nthe O\ncountry O\ntoward O\ndemocracy O\n. O\n\nThat O\nresulted O\nin O\ngeneral O\nelections O\nin O\nMarch O\n1973 O\nwhen O\nthe O\nPeronists B-ORG\nled O\nby O\nHector B-PER\nCampora I-PER\nand O\nVicente B-PER\nSolano I-PER\nLima I-PER\nreturned O\nto O\npower O\n. O\n\nLanusse B-PER\nwas O\na O\ncandidate O\nin O\nthe O\nelection O\nbut O\nfailed O\nto O\ndefeat O\nhis O\nold O\nadversories O\nand O\nnever O\nreturned O\nto O\npublic O\noffice O\n. O\n\nHe O\nwas O\nimprisoned O\nfor O\nfour O\nyears O\nin O\n1951 O\nfor O\ntaking O\npart O\nin O\na O\ncoup O\nattempt O\nto O\noverthrow O\nPeron B-PER\nled O\nby O\nGeneral O\nBenjamin B-PER\nMenendez I-PER\n. O\n\nLanusse B-PER\n's O\nrule O\nsaw O\nthe O\ngradual O\nrise O\nof O\nleft-wing O\nactivism O\nwhich O\nculminated O\nin O\nanother O\nperiod O\nof O\nbrutal O\nArgentine B-MISC\ndictatorship O\nfrom O\n1976 O\nto O\n1983 O\n, O\nduring O\nwhich O\nthe O\nmilitary O\nlaunched O\nits O\n\" O\ndirty O\nwar O\n\" O\nthat O\nresulted O\nin O\n10,000 O\nmissing O\npeople O\n. O\n\nIn O\nhis O\nautobiography O\npublished O\nin O\n1990 O\n, O\nLanusse B-PER\ndescribed O\nhimself O\nas O\na O\nmilitary O\nman O\nwith O\n\" O\ndemocratic O\nideas O\n. O\n\" O\n\nHe O\nwas O\nborn O\nin O\nBuenos B-LOC\nAires I-LOC\nin O\n1918 O\nand O\nmarried O\nIleana B-PER\nBell I-PER\nwith O\nwhom O\nhe O\nhad O\nnine O\nchildren O\n. O\n\nHe O\nentered O\nthe O\nMilitary B-ORG\nCollege I-ORG\nin O\n1935 O\n. O\n\n-DOCSTART- O\n\nTen O\nmissing O\nin O\nnorth O\nChina B-LOC\nship O\ncollision O\n. O\n\nBEIJING B-LOC\n1996-08-27 O\n\nTen O\npeople O\nwere O\nmissing O\nafter O\na O\nfishing O\nboat O\ncollided O\nwith O\na O\npassenger O\nliner O\nand O\nsank O\noff O\nChina B-LOC\n's O\nnortheastern O\nprovince O\nof O\nLiaoning B-LOC\n, O\nstate O\nradio O\nsaid O\non O\nTuesday O\n. O\n\nThe O\nfishing O\nboat O\nsank O\nand O\nits O\nentire O\ncrew O\nwas O\nmissing O\nafter O\na O\ncollision O\nwith O\nthe O\n\" O\nTiantan B-MISC\n\" O\nliner O\noff O\nthe O\nport O\nof O\nDalian B-LOC\nearly O\non O\nMonday O\n, O\nthe O\nreport O\nsaid O\n. O\n\nIt O\nsaid O\nthe O\nliner O\nwas O\nheading O\nto O\nDalian B-LOC\nfrom O\nthe O\nnorthern O\nport O\nof O\nTianjin B-LOC\n, O\nit O\nsaid O\n. O\n\nDalian B-LOC\nport O\nofficials O\n, O\ncontacted O\nby O\ntelephone O\n, O\nconfirmed O\nthe O\ncollision O\nbut O\ngave O\nno O\nfurther O\ndetails O\n. O\n\n-DOCSTART- O\n\nMatahari B-ORG\nrevises O\ndown O\n1996 O\nnet O\ntarget O\n. O\n\nJAKARTA B-LOC\n1996-08-27 O\n\nIndonesian B-MISC\ndepartment O\nstore O\noperator O\nPT B-ORG\nMatahari I-ORG\nPutra I-ORG\nPrima I-ORG\nsaid O\non O\nTuesday O\nthat O\nit O\nhad O\nrevised O\ndown O\nits O\n1996 O\nnet O\nprofit O\ntarget O\n. O\n\nMatahari B-ORG\n's O\nfinance O\ndirector O\n, O\nHanifah B-PER\nKomala I-PER\n, O\nsaid O\nthey O\nrevised O\ndown O\nnet O\nprofit O\nfor O\n1996 O\nto O\n46 O\nbillion O\nfrom O\nits O\noriginal O\ntarget O\nof O\n50 O\nbillion O\nrupiah O\n. O\n\n\" O\nWe O\nhave O\nto O\nrevised O\ndown O\nour O\ntarget O\ndue O\nto O\nweak O\nsales O\nperformance O\nin O\nthe O\nthird O\nquarter O\n, O\n\" O\nsaid O\nKomala B-PER\n. O\n\nHe O\nalso O\nsaid O\nthe O\ncompany O\nexpect O\nto O\nrecord O\na O\n83 O\nbillion O\nrupiah O\nof O\nnet O\nprofit O\nin O\n1997 O\n. O\n\n-- O\nJakarta B-LOC\nnewsroom O\n+6221 O\n384-6364 O\n\n-DOCSTART- O\n\nS. B-LOC\nKorea I-LOC\nasked O\nto O\nstop O\nChina-bound B-MISC\nmissionaries O\n. O\n\nBEIJING B-LOC\n1996-08-27 O\n\nBeijing B-LOC\nhas O\ncalled O\non O\nSeoul B-LOC\nto O\nstop O\nSouth B-MISC\nKorean I-MISC\nmissionaries O\nfrom O\ntravelling O\nto O\nChina B-LOC\n, O\na O\nSouth B-MISC\nKorean I-MISC\nembassy O\nspokesman O\nsaid O\non O\nTuesday O\n. O\n\nThe O\nappeal O\nwas O\nmade O\non O\nSunday O\nduring O\ntalks O\nbetween O\nSouth B-MISC\nKorean I-MISC\ndeputy O\nForeign O\nMinister O\nLee B-PER\nKi-choo I-PER\nand O\nhis O\nChinese B-MISC\ncounterpart O\nTang B-PER\nJiaxuan I-PER\n, O\nthe O\nspokesman O\nsaid O\n. O\n\nIt O\nis O\nnot O\nknown O\nwhy O\nChina B-LOC\nraised O\nthe O\nissue O\n. O\n\nAtheist O\nChina B-LOC\nofficially O\nbans O\nmissionary O\nactivities O\nbut O\noften O\nturns O\na O\nblind O\neye O\nto O\nreligious O\nactivities O\nof O\npeople O\nnominally O\nemployed O\nas O\nforeign O\nlanguage O\nteachers O\n, O\nparticularly O\nin O\nremote O\nareas O\nthat O\nare O\nunable O\nto O\nattract O\nother O\ncandidates O\n. O\n\n-DOCSTART- O\n\nHong B-LOC\nKong I-LOC\nnabs O\nblind O\n10-year-old O\nillegal O\nimmigrant O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-27 O\n\nA O\nblind O\n10-year-old O\nboy O\nfrom O\nChina B-LOC\nsneaked O\nover O\nthe O\nborder O\ninto O\nHong B-LOC\nKong I-LOC\nand O\nwas O\narrested O\nas O\nan O\nillegal O\nimmigrant O\n, O\nHong B-LOC\nKong I-LOC\npolice O\nsaid O\non O\nTuesday O\n. O\n\nHe O\nwas O\ncaught O\nby O\npolice O\ntrying O\nto O\nforce O\nhis O\nway O\ninto O\na O\nhome O\nin O\nthe O\nrural O\nNew B-LOC\nTerritories I-LOC\n, O\na O\npolice O\nspokesman O\nsaid O\n. O\n\n\" O\nThe O\nboy O\ncame O\nfrom O\nChina B-LOC\n's O\neastern O\nprovince O\nof O\nJiangsu B-LOC\n. O\n\nHe O\nwas O\nspotted O\nby O\na O\npasserby O\ntrying O\nto O\nclimb O\ninto O\nan O\napartment O\nin O\nthe O\nearly O\nhours O\nof O\nMonday O\nmorning O\n, O\n\" O\nthe O\nspokesman O\nsaid O\n. O\n\nNo O\ndecision O\nhas O\nyet O\nbeen O\nmade O\non O\nhow O\nto O\ndeal O\nwith O\nthe O\nboy O\n. O\n\nHong B-LOC\nKong I-LOC\npolice O\nregularly O\ncatch O\nhundreds O\nof O\nillegal O\nimmigrants O\nand O\npeople O\nwho O\nhave O\noverstayed O\ntheir O\nvisas O\nfrom O\nmainland O\nChina B-LOC\nand O\nsend O\nthem O\nback O\n. O\n\nHong B-LOC\nKong I-LOC\n, O\na O\nBritish B-MISC\ncolony O\n, O\nreverts O\nto O\nChinese B-MISC\ncontrol O\nnext O\nyear O\nbut O\nwill O\nremain O\nsealed O\noff O\nfrom O\nthe O\nmainland O\nexcept O\nto O\na O\ntiny O\ntrickle O\nof O\nlegal O\nimmigrants O\nand O\npeople O\nwith O\nspecial O\nvisit O\npermits O\n. O\n\n-DOCSTART- O\n\nBosnian B-MISC\npremier O\nin O\nTurkey B-LOC\nfor O\none O\nday O\nvisit O\n. O\n\nANKARA B-LOC\n1996-08-27 O\n\nBosnian B-MISC\nPrime O\nMinister O\nHasan B-PER\nMuratovic I-PER\narrived O\nin O\nAnkara B-LOC\non O\nTuesday O\nfor O\nan O\nofficial O\nvisit O\nwhere O\nhe O\nis O\ndue O\nto O\ndiscuss O\nTurkey B-LOC\n's O\naid O\nto O\nthe O\nformer O\nYugoslav B-MISC\nrepublic O\n. O\n\nThe O\npremier O\n, O\nwho O\nis O\ndue O\nto O\nmeet O\nhis O\nTurkish B-MISC\ncounterpart O\nNecmettin B-PER\nErbakan I-PER\non O\nTuesday O\n, O\nwill O\nalso O\nbe O\ndiscussing O\nthe O\npostponed O\nBosnian B-MISC\nelections O\n, O\na O\nforeign O\nministry O\nofficial O\nsaid O\n. O\n\nA O\nsmall O\nnumber O\nof O\nBosnians B-MISC\nhad O\nalso O\nbegun O\nto O\nvote O\nin O\nTurkey B-LOC\n. O\n\nMuratovic B-PER\nis O\nalso O\ndue O\nto O\nmeet O\nwith O\nPresident O\nSuleyman B-PER\nDemirel I-PER\n, O\nForeign O\nMinister O\nTansu B-PER\nCiller I-PER\nand O\nTurkish B-MISC\nbusinessman O\n, O\nthe O\nministry O\nofficial O\nsaid O\n. O\n\nHe O\nwill O\nleave O\non O\nThursday O\n. O\n\nA O\nU.S. B-LOC\ndiplomat O\nin O\ncharge O\nof O\nelections O\nin O\nBosnia B-LOC\nannounced O\nearlier O\nthat O\nmunicipal O\npolls O\ndue O\non O\nSeptember O\n14 O\nwith O\nother O\nBosnian B-MISC\nelections O\nwould O\nbe O\nput O\noff O\nbecause O\nof O\nirregularities O\nby O\nthe O\nSerbs B-MISC\nin O\nregistering O\nvoters O\n. O\n\nHe O\nsaid O\nno O\nnew O\ndate O\nhad O\nbeen O\nset O\nyet O\n. O\n\n\" O\nTurkish B-MISC\npeople O\nare O\nwatching O\nclosely O\nthe O\ndevelopments O\nin O\nBosnia B-LOC\n. O\n\nWe O\nhave O\nseen O\nelections O\nas O\na O\nstep O\nin O\nthe O\nnormalisation O\nprocess O\n, O\n\" O\nthe O\nforeign O\nministry O\nofficial O\nsaid O\n. O\n\n-DOCSTART- O\n\nNew O\nU.N. B-ORG\nrelief O\ncoordinator O\narrives O\nin O\nIraq B-LOC\n. O\n\nLeon B-PER\nBarkho I-PER\n\nBAGHDAD B-LOC\n1996-08-27 O\n\nA O\nnew O\nU.N. B-ORG\nrelief O\ncoordinator O\nhas O\narrived O\nin O\nBaghdad B-LOC\nto O\ntake O\nup O\nthe O\ntask O\nof O\norganising O\nhumanitarian O\ngoods O\ndistribution O\nand O\nto O\nface O\nIraq B-LOC\n's O\ncontinuing O\nopposition O\nover O\nthe O\nnumber O\nof O\ninternational O\nmonitors O\nto O\nbe O\ninvolved O\n. O\n\nU.N. B-ORG\nand O\ndiplomatic O\nsources O\nsaid O\non O\nTuesday O\nthat O\nSecretary- O\nGeneral O\nBoutros B-PER\nBoutros-Ghali I-PER\nhad O\nappointed O\nItalian B-MISC\nGualtiero B-PER\nFulcheri I-PER\nand O\nsent O\nhim O\nto O\nIraq B-LOC\nlast O\nweek O\nto O\nreplace O\nMoroccan B-MISC\nMohamed B-PER\nZejjari I-PER\n. O\n\nOne O\ndiplomat O\nsaid O\nIraq B-LOC\nand O\nU.N. B-ORG\nwere O\nstill O\nin O\ndisagreement O\non O\nhow O\nmany O\ninternational O\nobservers O\nwould O\nbe O\nrequired O\nto O\nascertain O\nthe O\nequitable O\ndistribution O\nof O\nhumanitarian O\nsupplies O\nthat O\nwill O\nbe O\nprocured O\nunder O\nBaghdad B-LOC\n's O\noil O\ndeal O\nwith O\nU.N O\n. O\n\n\" O\nThe O\nUnited B-ORG\nNations I-ORG\nwould O\nlike O\nto O\nemploy O\nhundreds O\nof O\nforeign O\nmonitors O\n. O\n\nBaghdad B-LOC\nsays O\nit O\ncan O\nonly O\naccept O\na O\nfew O\ndozens O\n, O\n\" O\nsaid O\nthe O\ndiplomat O\n. O\n\nBaghdad B-LOC\nholds O\nthat O\nthe O\nIraq-U.N. B-MISC\nmemorandum O\nof O\nunderstanding O\non O\npartial O\noil O\nsales O\nsigned O\nlast O\nJune O\ndoes O\nnot O\nspecify O\nhow O\nmany O\nforeign O\nobservers O\nshould O\nbe O\nstationed O\nin O\nIraq B-LOC\n. O\n\n\" O\nObservation O\nof O\nfood O\nsupplies O\nand O\ntheir O\ndistribution O\nare O\nstill O\na O\nmajor O\nissue O\nand O\nseems O\nthe O\ntwo O\nsides O\nhave O\nnot O\nyet O\nfilled O\nthe O\ngap O\nseparating O\nthem O\n, O\n\" O\nsaid O\nanother O\ndiplomat O\n. O\n\nIraq B-LOC\n's O\npartial O\noil O\nsales O\npact O\nwith O\nU.N. B-ORG\n, O\nallowing O\ncrude O\nexports O\nworth O\n$ O\n2 O\nbillion O\nevery O\nsix O\nmonths O\n, O\ngives O\nU.N. B-ORG\nthe O\nright O\nto O\nsupervise O\nthe O\npurchase O\nand O\ndistribution O\nof O\nfood O\nsupplies O\nin O\nthe O\ncountry O\n. O\n\nThe O\ndeal O\nis O\na O\nhumanitarian O\nexception O\nto O\nthe O\nU.N. B-ORG\nsanctions O\nimposed O\non O\nIraq B-LOC\nfor O\ninvading O\nKuwait B-LOC\nin O\n1990 O\nwhich O\ninclude O\na O\nban O\non O\nits O\noil O\nexports O\n. O\n\nFulcheri B-PER\ndeclined O\ncomment O\non O\nthe O\ndifferences O\nbetween O\nthe O\nU.N. B-ORG\nand O\nIraq B-LOC\n, O\nsaying O\nonly O\n: O\n\" O\nThere O\nare O\nseveral O\ndifferent O\nthings O\nwhich O\nstill O\nneed O\nto O\nbe O\ndone O\n. O\n\" O\n\nFulcheri B-PER\nstarted O\nhis O\nU.N. B-ORG\ncareer O\nin O\n1960 O\nand O\nhas O\nlong O\nexperience O\nin O\nU.N. B-ORG\nemergency O\nrelief O\nin O\nCongo B-LOC\n, O\nAngola B-LOC\n, O\nSudan B-LOC\nand O\nSomalia B-LOC\n. O\n\n-DOCSTART- O\n\nKansas B-LOC\nfeedlot O\ncattle O\nmarket O\nquiet O\n, O\nno O\nsales O\n- O\nUSDA B-ORG\n. O\n\nDODGE B-LOC\nCITY I-LOC\n1996-08-27 O\n\nTrade O\nwas O\nquiet O\n, O\nwith O\nno O\nsales O\nslaughter O\nsteers O\nor O\nheifers O\nconfirmed O\n. O\n\nInquiry O\nand O\ndemand O\nvery O\nlight O\n. O\n\nSales O\nconfirmed O\nweek O\nto O\ndate O\non O\n4,200 O\nhead O\n, O\nmostly O\npreviously O\ncontracted O\nor O\nformulated O\ncattle O\n. O\n\nConfirmed O\n- O\nnone O\n. O\n\n-- O\nChicago B-LOC\nnewsdesk O\n312 O\n408 O\n8720-- O\n\n-DOCSTART- O\n\nAnti-abortion O\nspeaker O\npraises O\nDemocrat B-MISC\ntolerance O\n. O\n\nAlan B-PER\nElsner I-PER\n\nCHICAGO B-LOC\n1996-08-27 O\n\nAn O\nanti-abortion O\npolitician O\naddressed O\nthe O\nDemocratic B-MISC\nconvention O\non O\nTuesday O\n, O\nbut O\npraised O\nthe O\noverwhelmingly O\npro-abortion O\nrights O\nparty O\nfor O\nits O\ntolerance O\nof O\nhis O\nminority O\nviews O\n. O\n\nRep B-MISC\n. O\n\nTony B-PER\nHall I-PER\nof O\nOhio B-LOC\nsaid O\nhe O\nand O\nother O\nDemocrats B-MISC\nwho O\nopposed O\nabortion O\nhad O\nalways O\nfelt O\nleft O\nout O\nin O\ntheir O\nown O\nparty O\n. O\n\n\" O\nBut O\nthis O\nyear O\nis O\ndifferent O\n. O\n\nFor O\nthe O\nfirst O\ntime O\n, O\nthe O\nDemocratic B-ORG\nParty I-ORG\nhas O\nincluded O\nin O\nour O\nplatform O\na O\nconscience O\nclause O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\nclause O\nrecognizes O\nand O\nwelcomes O\nDemocrats B-MISC\nwith O\ndivergent O\nviews O\non O\nabortion O\nand O\nstates O\nthey O\nhave O\na O\nfull O\npart O\nto O\nplay O\nat O\nall O\nlevels O\nof O\nthe O\nparty O\n. O\n\n\" O\nThe O\nDemocratic B-ORG\nParty I-ORG\nis O\nindeed O\nthe O\nparty O\nof O\ntrue O\ninclusiveness O\n, O\n\" O\nHall B-PER\nsaid O\n. O\n\nAt O\nits O\nconvention O\nfour O\nyears O\nago O\n, O\norganizers O\nprevented O\nthen O\nPennsylvania B-LOC\nGov O\n. O\n\nRobert B-PER\nCasey I-PER\n, O\na O\nvehement O\nopponent O\nof O\nabortion O\n, O\nfrom O\nspeaking O\n. O\n\nRepublicans B-MISC\nhave O\nused O\ntheir O\ndecision O\nas O\nan O\nexample O\nof O\nDemocrat B-MISC\nintolerance O\never O\nsince O\n. O\n\nCasey B-PER\ntold O\na O\nnews O\nconference O\nin O\nChicago B-LOC\non O\nTuesday O\nhe O\nhad O\nasked O\nto O\nspeak O\nagain O\nthis O\nyear O\nbut O\nwas O\nturned O\ndown O\n. O\n\nDemocratic B-MISC\nleaders O\nsaid O\nthere O\nwas O\nnot O\nroom O\non O\nthe O\nprogram O\nfor O\nevery O\nretired O\ngovernor O\nto O\nspeak O\n. O\n\n\" O\nI O\nbelieve O\nthe O\nDemocratic B-MISC\nparty O\nought O\nto O\nbe O\npro-woman O\n, O\npro-child O\nand O\npro-life O\n, O\n\" O\nCasey B-PER\nsaid O\n. O\n\n\" O\nI O\nasked O\nfor O\nthe O\nopportunity O\nto O\ndeliver O\nthis O\nmessage O\nfrom O\nthe O\npodium O\nof O\nthe O\nDemocrat B-ORG\nNational I-ORG\nConvention I-ORG\n. O\n\nFor O\nthe O\nsecond O\ntime O\nin O\nfour O\nyears O\n, O\nmy O\nrequest O\nfell O\non O\ndeaf O\nears O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\nRepublican B-ORG\nParty I-ORG\n, O\nwhose O\nplatform O\ncalls O\nfor O\nmaking O\nall O\nabortions O\nillegal O\n, O\nfaced O\na O\nsimilar O\ndilemma O\nthis O\nyear O\nwhen O\nMassachusetts B-LOC\nGov O\n. O\n\nWilliam B-PER\nWeld I-PER\nasked O\nto O\ndeliver O\na O\nspeech O\ndefending O\nabortion O\nrights O\nand O\nwas O\nturned O\ndown O\n. O\n\nBob B-PER\nDole I-PER\n, O\nthe O\nRepublican B-MISC\npresidential O\nnominee O\n, O\ntried O\nand O\nfailed O\nto O\ninsert O\na O\ntolerance O\nclause O\nin O\nhis O\nparty O\n's O\nplatform O\nrecognizing O\nthe O\nvalidity O\nof O\nthose O\nwithin O\nthe O\nparty O\nwho O\nsupported O\nabortion O\nrights O\n. O\n\nDemocrats B-MISC\nalso O\nheard O\nTuesday O\ntwo O\npassionate O\nspeeches O\ndefending O\nabortion O\nrights O\n. O\n\nKate B-PER\nMichelman I-PER\n, O\npresident O\nof O\nthe O\nNational B-ORG\nAbortion I-ORG\nRights I-ORG\nAction I-ORG\nLeague I-ORG\n, O\ndescribed O\nhow O\nshe O\nhad O\nan O\nabortion O\nat O\na O\ntime O\nwhen O\nthe O\nprocedure O\nwas O\nillegal O\nafter O\nher O\nhusband O\nabandoned O\nher O\nwith O\nthree O\nyoung O\nchildren O\n. O\n\n\" O\nI O\n'm O\nhere O\nto O\nspeak O\nup O\nfor O\nchoice O\nand O\nto O\nspeak O\nfor O\ntruth O\n. O\n\nThe O\nmessage O\nfrom O\nthe O\nRepublican B-ORG\nParty I-ORG\nis O\none O\nof O\ndisdain O\n. O\n\nTheir O\nanswer O\nto O\nchoice O\nis O\ncontrol O\nand O\npunishment O\n. O\n\nOur O\nanswer O\nis O\ntrust O\n, O\ncompassion O\nand O\nrespect O\n, O\n\" O\nshe O\nsaid O\n. O\n\nGeorgia B-LOC\nRep B-MISC\n. O\n\nCynthia B-PER\nMcKinney I-PER\nsaid O\n: O\n\" O\nYou O\nmake O\nyour O\nmoral O\ndecisions O\n. O\n\nI O\n'll O\nmake O\nmine O\nand O\nlet O\n's O\nleave O\n( O\nRepublican B-ORG\nHouse I-ORG\nSpeaker O\n) O\nNewt B-PER\nGingrich I-PER\nout O\nof O\nit O\n. O\n\" O\n\n-DOCSTART- O\n\nU.S. B-LOC\nSpring O\n/ O\nWhite O\nWheat O\n- O\nBids O\nmostly O\nsteady O\n. O\n\nCHICAGO B-LOC\n1996-08-27 O\n\nDark O\nnorthern O\nspring O\nand O\nwhite O\nwheat O\nbids O\nwere O\nmostly O\nsteady O\non O\nTuesday O\nbut O\na O\nfew O\nlocations O\nquoted O\nweaker O\nvalues O\nas O\nnewly O\nharvested O\nspring O\nwheat O\nflooded O\nthe O\nmarket O\n, O\nseveral O\ncash O\ngrain O\ndealers O\nsaid O\n. O\n\n\" O\nThere O\n's O\ntoo O\nmuch O\nnearby O\nwheat O\ncoming O\ninto O\nthe O\nmarket O\nso O\nwe O\n're O\nbacking O\noff O\nthe O\nbasis O\nto O\nslow O\nit O\ndown O\n, O\n\" O\na O\nMontana B-LOC\ndealer O\nsaid O\n. O\n\nBids O\nthere O\ndropped O\n10 O\ncents O\nper O\nbushel O\n. O\n\nHarvest O\nwas O\nalso O\nprogressing O\nwell O\nin O\nparts O\nof O\nNorth B-LOC\nDakota I-LOC\n, O\nbut O\none O\ndealer O\nthere O\nsaid O\nnew O\ncrop O\nmovement O\nremained O\nlimited O\nto O\na O\nsteady O\ntrickle O\n. O\n\" O\n\nWe O\n're O\nseeing O\nsome O\nnew O\ncrop O\ncoming O\nin O\nnow O\nbut O\nit O\n's O\nslow O\ngoing O\n, O\n\" O\nthe O\ndealer O\nsaid O\n. O\n\nElsewhere O\n, O\nbasis O\nvalues O\nwere O\nmostly O\nsteady O\nin O\nquiet O\nconditions O\nwith O\nlittle O\nnoteworty O\ndomestic O\nor O\nexport O\nbusiness O\n, O\ndealers O\nsaid O\n. O\n\nDurum O\nbids O\nwere O\nsteady O\nafter O\njumping O\n50 O\ncents O\nper O\nbushel O\nin O\nsome O\nareas O\non O\nMonday O\n. O\n\nPrice O\nper O\nbushel O\nfor O\n14-pct O\nprotein O\ndark O\nnorthern O\nspring O\n, O\ndurum O\nand O\nwhite O\nwheats O\n, O\nin O\ndollars O\nper O\nbushel O\n: O\n\nSpring O\nChg O\nDurum O\n( O\nm O\n) O\nChg O\nWhite O\nChg O\n\nMINNESOTA B-LOC\n\nMinneapolis B-LOC\n5.06 O\nup O\n.02 O\n5.75 O\nunc O\n-- O\n-- O\n\nDuluth B-LOC\n5.06 O\nup O\n.02 O\n--- O\n--- O\n-- O\n-- O\n\nNORTH B-LOC\nDAKOTA I-LOC\n\nHunter B-LOC\n\n( O\nRed B-LOC\nRiver I-LOC\n) O\n4.46 O\ndn O\n.02 O\n5.00 O\nunc O\n-- O\n-- O\n\nSpring B-LOC\nChg O\nHRW O\n12pct O\nChg O\nWhite O\nChg O\n\nBillings B-LOC\nMT B-LOC\n4.62 O\nup O\n.01 O\n4.50 O\ndn O\n.01 O\n--- O\n--- O\n\nHavre B-LOC\nMT B-LOC\n4.54 O\ndn O\n.10 O\n--- O\n--- O\n--- O\n--- O\n\nRudyard B-LOC\nMT B-LOC\n4.54 O\ndn O\n.10 O\n--- O\n--- O\n--- O\n--- O\n\nWolf B-LOC\nPoint I-LOC\nMT B-LOC\n4.41 O\ndn O\n.10 O\n--- O\n--- O\n--- O\n--- O\n\nPortland B-LOC\nOR B-LOC\n5.60 O\nup O\n.02 O\n5.1700 O\ndn O\n.01 O\n\nPendleton B-LOC\nOR B-LOC\n--- O\n--- O\n--- O\n--- O\n4.7300 O\nup O\n.01 O\n\nCoolee B-LOC\nCity I-LOC\nWA B-LOC\n5.13 O\nup O\n.02 O\n--- O\n--- O\n4.7000 O\nunc O\n\nWaterville B-LOC\nWA B-LOC\n5.05 O\nup O\n.02 O\n--- O\n--- O\n4.6200 O\nunc O\n\nWenatchee B-LOC\nWA B-LOC\n5.15 O\nup O\n.02 O\n--- O\n--- O\n4.7200 O\nunc O\n\nnote O\n: O\nnc=acomparison O\n, O\nna=not O\navailable O\n\n( O\nChicago B-LOC\nbureau O\n312-408-8720 O\n) O\n\n-DOCSTART- O\n\nBirmingham B-LOC\nPublic I-LOC\nPark I-LOC\n, O\nAla B-LOC\n. O\n\n, O\nAa3 O\n/ O\nVMIG-1 O\n- O\nMoody B-ORG\n's I-ORG\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-27 O\n\nMoody B-ORG\n's I-ORG\nInvestors I-ORG\nService I-ORG\n- O\n\nRating O\nAnnouncement O\nAs O\nof O\n08/23/96 O\n. O\n\nIssuer O\n: O\nBirmingham B-LOC\nPublic I-LOC\nPark I-LOC\n& I-LOC\nRec I-LOC\n. O\n\nBd O\n. O\n\nRevenue O\n\nref O\n. O\n\n( O\nYMCA B-ORG\nProj O\n. O\n\n) O\nser O\n. O\n' O\n\n96 O\n\nState O\n: O\nAL B-LOC\n\nRating O\n: O\nAa3 O\n/ O\nVMIG O\n1 O\n\nSale O\nAmount O\n: O\n3,390,000 O\n\nExpected O\nSale O\nDate O\n: O\n08/28/96 O\n\n-- O\nU.S. B-ORG\nMunicipal I-ORG\nDesk I-ORG\n, O\n212-859-1650 O\n\n-DOCSTART- O\n\nU.S. B-LOC\nlauds O\nRussian-Chechen B-MISC\ndeal O\n. O\n\nWASHINGTON B-LOC\n1996-08-27 O\n\nThe O\nUnited B-LOC\nStates I-LOC\non O\nTuesday O\nwelcomed O\na O\ndeal O\naimed O\nat O\nresuming O\na O\ntroop O\nwithdrawal O\nfrom O\nthe O\nembattled O\nChechen B-MISC\ncapital O\n, O\nGrozny B-LOC\n. O\n\n\" O\nThat O\nis O\na O\nwelcome O\ndevelopment O\n. O\n\nWe O\nurge O\nboth O\nsides O\nto O\ncontinue O\ntheir O\ndialogue O\naimed O\nat O\nreaching O\na O\npolitical O\nsettlement O\n\" O\nof O\nthe O\n20-month O\nconflict O\nbetween O\nRussian B-MISC\ntroops O\nand O\nChechen B-MISC\nrebels O\n, O\nState B-ORG\nDepartment I-ORG\nspokesman O\nGlyn B-PER\nDavies I-PER\nsaid O\n. O\n\nThe O\ncommander O\nof O\nRussian B-MISC\ntroops O\nin O\nChechnya B-LOC\n, O\nVyacheslav B-PER\nTikhomirov I-PER\n, O\nand O\nChechen B-MISC\nrebel O\nchief-of-staff O\nAslan B-PER\nMashadov I-PER\nsigned O\nthe O\ndeal O\nunder O\nwhich O\nthe O\ntroop O\nwithdrawal O\nis O\nto O\nresume O\non O\nWednesday O\n. O\n\n-DOCSTART- O\n\nAkron B-LOC\n, O\nOhio B-LOC\n, O\n$ O\n6 O\nmln O\nbonds O\nrated O\nsingle-A O\n- O\nMoody B-ORG\n's I-ORG\n. O\n\nNEW B-LOC\nYORK I-LOC\n, O\nAug O\n27 O\n- O\nMoody B-ORG\n's I-ORG\nInvestors I-ORG\nService I-ORG\n- O\nRating O\n\nAnnouncement O\nAs O\nof O\n08/26/96 O\n. O\n\nIssuer O\n: O\nAkron B-ORG\n\nState O\n: O\nOH B-LOC\n\nRating O\n: O\nA O\n\nSale O\nAmount O\n: O\n6,310,000 O\n\nExpected O\nSale O\nDate O\n: O\n08/28/96 O\n\n-DOCSTART- O\n\nStallone B-PER\n, O\nfiancee O\nhave O\nbaby O\ngirl O\n. O\n\nMIAMI B-LOC\n1996-08-27 O\n\nActor O\nSylvester B-PER\nStallone I-PER\nand O\nhis O\nfiancee O\n, O\nmodel O\nJennifer B-PER\nFlavin I-PER\n, O\nhad O\na O\nbaby O\ngirl O\non O\nTuesday O\n, O\nStallone B-PER\n's O\npublicist O\nsaid O\n. O\n\nThe O\n7-pound O\n, O\n4-ounce O\n( O\n3.3 O\nkg O\n) O\ngirl O\n, O\nnamed O\nSophia B-PER\nRose I-PER\n, O\nwas O\nborn O\nshortly O\nafter O\nmidnight O\nat O\nSouth B-LOC\nMiami I-LOC\nHospital I-LOC\n, O\npublicist O\nPaul B-PER\nBloch I-PER\nsaid O\n. O\n\n\" O\nBoth O\nmother O\nand O\nbaby O\nare O\ndoing O\nfine O\nand O\nare O\nin O\nwonderful O\nhealth O\n, O\n\" O\nhe O\nsaid O\n, O\nadding O\nthat O\nit O\nwas O\nthe O\ncouple O\n's O\nfirst O\nchild O\n. O\n\nHe O\nsaid O\nStallone B-PER\n, O\nbest O\nknown O\nfor O\nthe O\n\" O\nRocky B-MISC\n\" O\nand O\n\" O\nRambo B-MISC\n\" O\nmovies O\n, O\nleft O\nthe O\nset O\nof O\n\" O\nCopland B-MISC\n, O\n\" O\nwhich O\nis O\nfilming O\nin O\nNew B-LOC\nYork I-LOC\nand O\nNew B-LOC\nJersey I-LOC\n, O\nto O\nbe O\nwith O\nFlavin B-PER\nfor O\nthe O\nbirth O\n. O\n\n-DOCSTART- O\n\nPoll O\nshows O\nClinton B-PER\nlead O\nover O\nDole B-PER\njumps O\nto O\n15 O\npts O\n. O\n\nCHICAGO B-LOC\n1996-08-27 O\n\nAn O\nABC B-ORG\nNews I-ORG\npoll O\nreleased O\non O\nTuesday O\nshowed O\nPresident O\nBill B-PER\nClinton I-PER\n's O\nlead O\nover O\nRepublican B-MISC\nchallenger O\nBob B-PER\nDole I-PER\nstretching O\nto O\n15 O\npoints O\nin O\nadvance O\nof O\nthe O\nNov. O\n5 O\nelection O\n. O\n\nThe O\npoll O\n, O\ntaken O\non O\nSunday O\nand O\nMonday O\nas O\nthe O\npresident O\nengaged O\nin O\na O\nwhistle-stop O\ntrain O\ntrip O\nto O\nthe O\nDemocratic B-MISC\nConvention I-MISC\nin O\nChicago B-LOC\n, O\nput O\nClinton B-PER\nat O\n51 O\npercent O\n, O\nDole B-PER\nat O\n36 O\npercent O\nand O\nRoss B-PER\nPerot I-PER\nof O\nthe O\nReform B-ORG\nParty I-ORG\nat O\n8 O\npercent O\n. O\n\nA O\nsimilar O\npoll O\nconducted O\non O\nSaturday O\nand O\nSunday O\nhad O\nshowed O\na O\nnine O\npoint O\nlead O\nfor O\nClinton B-PER\n, O\nahead O\nby O\n47-38 O\npercent O\n. O\n\nDole B-PER\n, O\ndown O\nby O\naround O\n20 O\npoints O\nin O\nearly O\nAugust O\nin O\nABC B-ORG\npolls O\n, O\nhad O\nclosed O\nto O\nwithin O\nfour O\npercentage O\npoints O\nimmediately O\nafter O\nthe O\nRepublican B-MISC\nconvention O\nin O\nSan B-LOC\nDiego I-LOC\nearlier O\nin O\nAugust O\n. O\n\nOther O\npolls O\nalso O\nshowed O\na O\nstrong O\nDole B-PER\nbounce O\nafter O\nSan B-LOC\nDiego I-LOC\nbut O\nClinton B-PER\nthen O\nrebuilding O\nhis O\nlead O\n. O\n\nTuesday O\n's O\npoll O\ninvolved O\n1,002 O\nregistered O\nvoters O\nand O\nhad O\na O\nmargin O\nof O\nerror O\nof O\n3.5 O\npercentage O\npoints O\n. O\n\nABC B-ORG\nsaid O\na O\nparallel O\npoll O\nof O\n824 O\nlikely O\nvoters O\nshowed O\nthe O\npresident O\nahead O\nby O\n11 O\npoints O\n, O\nwith O\nClinton B-PER\nat O\n50 O\npercent O\n, O\nDole B-PER\nat O\n39 O\npercent O\nand O\nPerot B-PER\nat O\n6 O\npercent O\n. O\n\nThe O\npoll O\nof O\nregistered O\nvoters O\nshowed O\na O\nshift O\nin O\nfavor O\nof O\nthe O\nDemocrats B-MISC\nin O\nthe O\nelections O\nfor O\nHouse B-ORG\nof I-ORG\nRepresentatives I-ORG\n, O\nwith O\n51 O\npercent O\nsaying O\nthat O\nif O\nthe O\nvote O\nwere O\ntoday O\nthey O\nwould O\ngo O\nfor O\na O\nDemocrat B-MISC\nand O\n41 O\npercent O\nopting O\nfor O\na O\nRepublican B-MISC\n. O\n\nThat O\ncompared O\nwith O\nthe O\nprevious O\npoll O\n's O\n48-43 O\nlead O\nfor O\nthe O\nDemocrats B-MISC\n. O\n\nThe O\npoll O\ngave O\nClinton B-PER\na O\n53 O\npercent O\nto O\n39 O\npercent O\nlead O\nover O\nDole B-PER\nif O\nPerot B-PER\nwere O\nnot O\nin O\nthe O\nrace O\n. O\n\nThe O\npoll O\nindicated O\na O\nfall O\nin O\nthe O\nnumber O\nof O\npeople O\nwho O\nbelieved O\nDole B-PER\nwould O\nbe O\nable O\nto O\nfulfil O\nhis O\npromise O\nto O\ncut O\nthe O\nfederal O\nbudget O\ndeficit O\nand O\ncut O\nincome O\ntaxes O\nby O\n15 O\npercent O\nat O\nthe O\nsame O\ntime O\n. O\n\nIt O\nshowed O\n23 O\npercent O\nbelieved O\nit O\npossible O\ncompared O\nto O\n70 O\nwho O\nbelieved O\nit O\nwas O\nn't O\n. O\n\nThat O\ncompared O\nto O\n26-57 O\nin O\nthe O\nprevious O\npoll O\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nbulk O\nmillfeeds O\n- O\nImmediate O\nsupply O\ntight O\n. O\n\nCHICAGO B-LOC\n1996-08-27 O\n\nMillfeed O\nsupplies O\nfor O\nprompt O\nshipment O\nremained O\ntight O\nand O\nprices O\ncontinued O\nto O\nmove O\nhigher O\n, O\nmillfeed O\ndealers O\nsaid O\n. O\n\nHigh-priced O\ncorn O\nand O\nincreased O\ndemand O\nfor O\nlivestock O\nfeed O\ncontinued O\nto O\nsupport O\nmillfeed O\nprices O\nin O\nnearly O\nall O\nsectors O\n. O\n\nFlour O\nmills O\nsold O\nmuch O\nof O\ntheir O\nproduction O\nthrough O\nSeptember O\nleaving O\nlittle O\navailable O\nfor O\nprompt O\nshipment O\n. O\n\nPortland B-LOC\nsources O\nsaid O\nfeed O\nmixer O\ndemand O\nwas O\nkeeping O\npace O\nwith O\nmillfeed O\nproduction O\nand O\ndriving O\nprices O\nhigher O\n. O\n\nPortland B-LOC\nsources O\nsaid O\nwith O\ncorn O\npriced O\nthere O\nat O\n$ O\n200 O\nper O\nton O\nand O\nbarley O\nat O\n$ O\n140 O\n, O\nthe O\nmillfeeds O\nat O\n$ O\n125 O\nrepresent O\na O\ngood O\nvalue O\n. O\n\nIn O\nthe O\nsoutheast O\nU.S. B-LOC\n, O\ndealers O\nsaid O\nfeed O\nmixers O\ncontinued O\nto O\nbe O\nsteady O\nbuyers O\nwith O\ndemand O\nincreasing O\nfor O\nOctober O\nto O\nMarch O\npositions O\n. O\n\nThe O\nclosely-watched O\nKansas B-LOC\nCity I-LOC\nrail O\nmarket O\nwas O\nsteady O\nat O\n$ O\n115 O\nper O\nton O\nbid O\nand O\n$ O\n118 O\noffered O\n. O\n\n-- O\nChicago B-LOC\nnewsdesk O\n312-408-8720-- O\n\n-DOCSTART- O\n\nPuerto B-LOC\nRico I-LOC\ngirl O\nhas O\nsurgery O\nfor O\nhairy O\nface O\n. O\n\nPHILADELPHIA B-LOC\n1996-08-27 O\n\nA O\ntwo-year O\nold O\nPuerto B-MISC\nRican I-MISC\ngirl O\nbegan O\nsurgical O\ntreatment O\non O\nTuesday O\nfor O\na O\nrare O\ncondition O\nthat O\nhas O\nleft O\nhalf O\nof O\nher O\nface O\ncovered O\nwith O\na O\nhairy O\n, O\ndark-brown O\npatch O\nof O\nskin O\n. O\n\nThe O\ngirl O\n, O\nAbyss B-PER\nDeJesus I-PER\n, O\nsuffers O\nfrom O\na O\n\" O\nhairy O\nnevus O\n\" O\non O\nthe O\nright O\nside O\nof O\nher O\nface O\n, O\na O\ncondition O\nthat O\nhas O\nonly O\nbeen O\nreported O\na O\nfew O\ntimes O\nin O\nmedical O\njournals O\n, O\nthe O\nSt. B-LOC\nChristopher I-LOC\nChildren I-LOC\n's I-LOC\nHospital I-LOC\nsaid O\n. O\n\nIn O\naddition O\nto O\nsocial O\nostracism O\n, O\nthe O\ncondition O\nalso O\ncarries O\na O\nhigh O\nrisk O\nof O\ncancer O\n. O\n\nIt O\nwill O\nbe O\ncorrected O\nby O\ngradually O\nexpanding O\nhealthy O\nskin O\nwith O\na O\nsurgical O\nballoon O\n, O\nthen O\ntransplanting O\nthat O\nskin O\nto O\nthe O\nafflicted O\nside O\nof O\nher O\nface O\n. O\n\n\" O\nShe O\nis O\ndoing O\nwell O\n, O\n\" O\nhospital O\nspokeswoman O\nCarol B-PER\nNorris I-PER\nsaid O\n. O\n\" O\n\nThe O\nsurgery O\nis O\nunder O\nway O\n. O\n\" O\n\nNorris B-PER\nsaid O\nTuesday O\n's O\nsurgery O\ninvolved O\nplacing O\nfive O\nballoons O\nin O\nDeJesus B-PER\n's O\nforehead O\n, O\nshoulders O\nand O\nthe O\nback O\nof O\nher O\nneck O\nand O\npartially O\nfilling O\nthem O\nwith O\na O\nsaline O\nsolution O\n. O\n\nMore O\nsaline O\nsolution O\nwill O\nbe O\ninserted O\nin O\n16 O\nweekly O\ntreatments O\n. O\n\nThe O\ngirl O\n, O\nwho O\nwas O\naccompanied O\nto O\nPhiladelphia B-LOC\nby O\nher O\nparents O\n, O\nwill O\nneed O\nmore O\nsurgery O\nlater O\nto O\ncorrect O\nthe O\ncondition O\non O\nher O\nchest O\n, O\nback O\nand O\nlegs O\n, O\nthe O\nhospital O\nsaid O\n. O\n\n-DOCSTART- O\n\nEau B-ORG\nClaire I-ORG\n, O\nWisc B-LOC\n. I-LOC\n\nrevs O\nwon O\nby O\nRobert B-ORG\nW. I-ORG\nBaird I-ORG\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-27 O\n\nRobert B-ORG\nW. I-ORG\nBaird I-ORG\n& I-ORG\nCo I-ORG\n. I-ORG\n\n, B-ORG\nInc. I-ORG\n, O\nsaid O\nit O\nwon O\n$ O\n1 O\nmillion O\nof O\nEau B-ORG\nClaire I-ORG\n, O\nWisc B-LOC\n. I-LOC\n\n, O\nwaterworks O\nsystem O\nmortgage O\nrevenue O\nbonds O\n, O\nSeries O\n1996 O\n, O\nwith O\na O\ntrue O\ninterest O\ncost O\nof O\n5.2893 O\npercent O\n. O\n\n-DOCSTART- O\n\nMassachusetts B-LOC\nhome O\nsales O\ndip O\nin O\nJuly O\n- O\nreport O\n. O\n\nBOSTON B-LOC\n1996-08-27 O\n\nHome O\nsales O\nacross O\nMassachusetts B-LOC\nwere O\ndown O\n2.3 O\npercent O\nin O\nJuly O\n, O\ncompared O\nto O\na O\nmonth O\nearlier O\n, O\nbut O\nup O\n21 O\npercent O\nfor O\nthe O\nyear O\n, O\naccording O\nto O\nthe O\nMassachusetts B-ORG\nAssociation I-ORG\nof I-ORG\nRealtors I-ORG\n. O\n\nThe O\nassociation O\nsaid O\na O\ntotal O\nof O\n4,464 O\nsingle-family O\nhomes O\nwere O\nsold O\nin O\nJuly O\n, O\ncompared O\nto O\n4,570 O\nin O\nJune O\n. O\n\nThe O\naverage O\nselling O\nprice O\n, O\n$ O\n206,464 O\n, O\nwas O\nup O\n10.6 O\npercent O\nover O\nJuly O\n1995 O\n. O\n\nCondominium O\nsales O\nedged O\nup O\n6.0 O\npercent O\nfor O\nJuly O\nand O\n24.8 O\npercent O\nfor O\nthe O\nyear O\n, O\nthe O\ngroup O\nsaid O\n, O\nwhile O\nprices O\nfor O\ncondos O\nnudged O\nup O\nless O\nthan O\n1.0 O\npercent O\nto O\nan O\naverage O\nof O\n$ O\n123,394 O\n. O\n\nIn O\nJuly O\n, O\nthe O\naverage O\nrate O\non O\na O\n30-year O\nfixed O\nrate O\nmortgage O\nwas O\n8.25 O\npercent O\n, O\nbelow O\nJune O\n's O\n8.32 O\npercent O\nbut O\nstill O\nhigher O\nthan O\nFebruary O\n's O\n7.03 O\npercent O\n, O\nthe O\nreport O\nnoted O\n. O\n\n-- O\nBoston B-LOC\nbureau O\n, O\n617-367-4106 O\n\n-DOCSTART- O\n\nAmtrak B-ORG\ntrain O\nderails O\n, O\nthree O\ninjured O\n- O\nofficials O\n. O\n\nMONTPELIER B-LOC\n, O\nVt B-LOC\n. O\n\n1996-08-27 O\n\nAt O\nleast O\nthree O\npeople O\nwere O\ninjured O\nwhen O\nan O\nAmtrak B-ORG\npassenger O\ntrain O\nslammed O\ninto O\nan O\nempty O\nlogging O\ntruck O\nand O\nderailed O\nTuesday O\n, O\nofficials O\nsaid O\n. O\n\nThe B-MISC\nVermonter I-MISC\n, O\nwhich O\nruns O\nbetween O\nSt. B-LOC\nAlbans I-LOC\n, O\nVermont B-LOC\n, O\nnear O\nthe O\nCanadian B-MISC\nborder O\nand O\nWashington B-LOC\n, I-LOC\nD.C. I-LOC\n, O\ncollided O\nwith O\nthe O\ntruck O\nat O\n7:51 O\na.m. O\nEDT O\nnear O\nthe O\nrural O\ntown O\nof O\nRoxbury B-LOC\nsome O\n15 O\nmiles O\nsoutheast O\nof O\nthe O\nstate O\ncapital O\nMontpelier B-LOC\n, O\nAmtrak B-ORG\nspokeswoman O\nMaureen B-PER\nGarrity I-PER\nsaid O\n. O\n\nVermont B-LOC\nCentral I-LOC\nHospital I-LOC\nspokesman O\nDan B-PER\nPudvah I-PER\nsaid O\ntwo O\nof O\nthe O\ninjured O\nwere O\ntreated O\nthere O\n-- O\nthe O\ntruck O\ndriver O\n, O\nwho O\nwas O\nsuffering O\nfrom O\nmultiple O\ntrauma O\ninjuries O\n, O\nand O\na O\npassenger O\n. O\n\nPudvah B-PER\nsaid O\nhe O\nunderstood O\nother O\npeople O\nwith O\nminor O\ninjuries O\nwere O\nbeing O\ntreated O\nat O\nthe O\nscene O\n. O\n\nGarrity B-PER\nsaid O\na O\ntrain O\nconductor O\nwas O\nalso O\ninjured O\n. O\n\nThe O\ntrain O\n's O\nengine O\nand O\nits O\nsix O\ncars O\nderailed O\nbut O\nwere O\nstill O\nstanding O\n, O\nstate O\npolice O\nsaid O\n. O\n\nThe O\nexact O\nnumber O\nof O\npassangers O\non O\nthe O\ntrain O\nwas O\nnot O\nknown O\n. O\n\" O\n\nWe O\nhad O\n70 O\nreservations O\nfor O\nthe O\ntrain O\n, O\nbut O\nthat O\ndoes O\nn't O\nmean O\nthere O\nwere O\n70 O\npassengers O\naboard O\n, O\n\" O\nGarrity B-PER\nsaid O\n. O\n\nUninjured O\npassengers O\nwere O\nto O\nbe O\ntaken O\nby O\nbus O\nto O\nSpringfield B-LOC\n, O\nMassachusetts B-LOC\n, O\nwhere O\nthey O\nwill O\nbe O\nput O\naboard O\nanother O\ntrain O\nto O\ncontinue O\ntheir O\njourney O\nto O\nNew B-LOC\nYork I-LOC\nCity I-LOC\nand O\nWashington B-LOC\n, O\nGarrity B-PER\nsaid O\n. O\n\nShe O\nsaid O\nthe O\ntrain O\nwas O\ntravelling O\nat O\n54 O\nmph O\nwhen O\nit O\ncrashed O\ninto O\nthe O\ntruck O\n, O\nwhich O\nwas O\ncrossing O\nthe O\ntracks O\nonto O\na O\ndirt O\nroad O\nin O\nthe O\nrural O\narea O\nbordering O\nthe O\nNorthfield B-LOC\nMountains I-LOC\n. O\n\n-DOCSTART- O\n\nParalympics B-MISC\nan O\nexample O\nfor O\ngloomy O\nFrance-Juppe B-MISC\n. O\n\nPARIS B-LOC\n1996-08-27 O\n\nPrime O\nMinister O\nAlain B-PER\nJuppe I-PER\non O\nTuesday O\nhailed O\nhandicapped O\nathletes O\nwho O\ntook O\npart O\nin O\nAtlanta B-LOC\n's O\nParalympic B-MISC\nGames I-MISC\nas O\nan O\nexample O\nfor O\ngloom-stricken O\nFrance B-LOC\n. O\n\n\" O\nWhat O\nwe O\nhear O\nevery O\nmorning O\nis O\ngloom O\n, O\nresignation O\nand O\nscepticism O\n... O\n\nYou O\nare O\nthe O\nopposite O\n, O\n\" O\nJuppe B-PER\ntold O\na O\nsuccessful O\nFrench B-MISC\nteam O\nat O\nParis B-LOC\nairport O\nas O\nhe O\nwelcomed O\nthem O\nback O\nfrom O\nthe O\ngames O\nwhich O\nfollowed O\nthe O\nJuly-August O\nOlympics B-MISC\n. O\n\n\" O\nIf O\nyou O\nhad O\nbeen O\nstruck O\n... O\n\nby O\nthe O\ndisease O\nof O\nscepticism O\n, O\ngloom O\nand O\nresignation O\n, O\nyou O\nwould O\nnot O\nbe O\nhere O\n. O\n\nYou O\nare O\na O\ntrue O\nexample O\nfor O\nthe O\nnation O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\nFrench B-MISC\nteam O\nwon O\n95 O\nmedals O\nin O\nAtlanta B-LOC\n, O\n35 O\nof O\nthem O\ngold O\n. O\n\nOpinion O\npolls O\nconsistently O\nshow O\nFrench B-MISC\nvoters O\npessimistic O\nand O\nfed O\nup O\nas O\nthe O\neconomy O\nstagnates O\nand O\nunemployement O\nlingers O\nat O\nnear-record O\nlevels O\n. O\n\n-DOCSTART- O\n\nFrench B-MISC\nshares O\nend O\nfractionally O\nweaker O\n. O\n\nPARIS B-LOC\n1996-08-27 O\n\nFrench B-MISC\nshares O\nended O\nfractionally O\nweaker O\nas O\nunease O\nabout O\nunion O\nunrest O\nslated O\nfor O\nthe O\nautumn O\nand O\na O\nweaker O\nfranc O\ngot O\nthe O\nbetter O\nof O\na O\nslight O\nrise O\non O\nWall B-LOC\nStreet I-LOC\n. O\n\nThe O\nblue-chip O\nCAC-40 B-MISC\nindex O\nended O\n2.43 O\npoints O\nor O\n0.12 O\npercent O\nlower O\nat O\n2,017.99 O\npoints O\nafter O\na O\nbrief O\nforay O\ninto O\npositive O\nterritory O\nwhen O\nthe O\nNew B-LOC\nYork I-LOC\nstock O\nmarket O\nopened O\nhigher O\n. O\n\nThe O\nbroader O\nSBF-120 B-MISC\nindex O\nclosed O\n1.19 O\npoints O\nor O\n0.08 O\npercent O\nlower O\nat O\n1,421.90 O\npoints O\n. O\n\nMarket O\nturnover O\nwas O\n3.8 O\nbillion O\nfrancs O\n, O\nabout O\naverage O\nfor O\nthe O\nquiet O\nAugust O\nperiod O\n, O\nincluding O\n2.6 O\nbillion O\non O\nthe O\nmost O\nactively O\ntraded O\nCAC-40 B-MISC\nshares O\n. O\n\nThe O\nSocialist O\nCFDT B-ORG\nunion O\nwarned O\nof O\n\" O\ntension O\nand O\nconflict O\n\" O\nwhen O\nFrance B-LOC\nreturns O\nto O\nwork O\nafter O\nthe O\nsummer O\nbreak O\nand O\ncalled O\nfor O\na O\ndrive O\nto O\ncreate O\nup O\nto O\n500,000 O\njobs O\nin O\nnine O\nmonths O\n. O\n\nA O\nteachers O\n' O\nunion O\n, O\nthe O\nFederation B-ORG\nSyndicale I-ORG\nUnitaire I-ORG\n( O\nFSU B-ORG\n) O\n, O\ncalled O\nfor O\nmembers O\nto O\nprotest O\nagainst O\njob O\ncuts O\nexpected O\nin O\nthe O\ngovernment O\n's O\nausterity O\nbudget O\ndue O\nto O\nbe O\nunveiled O\nin O\nSeptember O\n. O\n\nAnxieties O\nover O\nthe O\nbudget O\nniggled O\nthe O\ncurrency O\nmarkets O\nwhere O\nthe O\nfranc O\nlost O\naround O\nhalf O\na O\ncentime O\nfrom O\nMonday O\n's O\nlate O\nEuropean B-MISC\nlevels O\nto O\n3.4211 O\nper O\nmark O\n. O\n\nIndex O\nheavyweights O\nElf B-ORG\nand O\nRhone B-ORG\nPoulenc I-ORG\nboth O\nended O\nslightly O\nweaker O\nwhile O\nactive O\nEurotunnel B-LOC\nwas O\nunchanged O\non O\nnearly O\na O\nmillion O\nshares O\ntraded O\n. O\n\n\" O\nPeople O\nare O\nmorose O\nand O\nit O\n's O\nnot O\nthe O\npost-holiday O\nperiod O\nor O\nthe O\nbudget O\nor O\ncompany O\nresults O\nthat O\nare O\ngoing O\nto O\nlift O\nanyone O\n's O\nspirits O\n, O\n\" O\na O\nbroker O\nsaid O\n. O\n\n* O\nUIC B-ORG\n, O\npart O\nof O\ninsurer O\nGAN B-ORG\n, O\nslid O\n12.19 O\npercent O\nto O\n55.1 O\nfrancs O\nafter O\nreporting O\na O\nnet O\nattributable O\nfirst-half O\nloss O\nof O\n758 O\nmillion O\nfrancs O\nafter O\nthe O\nclose O\non O\nMonday O\n. O\n\nMarkets O\nwere O\ndisappointed O\nby O\na O\nrecapitalisation O\nof O\n800 O\nmillion O\nfrancs O\nwhich O\ncommentators O\nsaid O\nwas O\nlarger O\nthan O\nexpected O\n. O\n\n* O\nSupermarkets O\ngroup O\nCarrefour B-ORG\ngained O\n2.19 O\npercent O\nto O\n2,616 O\nfrancs O\nafter O\nbrokers O\nCheuvreux B-ORG\nde I-ORG\nVirieu I-ORG\nconfirmed O\nthe O\nstock O\non O\ntheir O\nbuy O\nlist O\n, O\na O\nfund O\nmanager O\nsaid O\n. O\n\n* O\nReinsurance O\ngroup O\nScor B-ORG\ngained O\n2.1 O\npercent O\nto O\n202 O\nfrancs O\non O\nnews O\nthat O\nBritish B-MISC\ninsurer O\nPrudential B-ORG\nhad O\nsold O\nits O\nMercantile B-ORG\n& I-ORG\nGeneral I-ORG\nreinsurance O\nbusiness O\nto O\nSwiss B-MISC\nRe B-ORG\n. O\n\n* O\nConglomerate O\nBollore B-ORG\nlost O\n2.4 O\npercent O\nto O\n521 O\nfrancs O\nafter O\na O\nmorning O\ntrading O\nsuspension O\nduring O\nwhich O\nit O\nsaid O\nit O\nhad O\napproved O\nplans O\nto O\nbuy O\nout O\nits O\n73.83 O\npercent O\nowned O\ntransport O\nunit O\nScac B-ORG\nDelmas I-ORG\nVileujeux I-ORG\n( O\nSDV B-ORG\n) O\nand O\ninvited O\nshareholders O\nto O\ntender O\ntheir O\nshares O\n. O\n\n* O\nAlcatel B-ORG\nAlsthom I-ORG\nfell O\n1.7 O\npercent O\nto O\n395.0 O\n. O\n\n* O\nOpthalmic B-MISC\nproducts O\nmanufacturer O\nEssilor B-ORG\ngained O\n2.6 O\npercent O\nto O\n1,328 O\nfrancs O\nafter O\nOakley B-ORG\nInc I-ORG\nof O\nthe O\nUnited B-LOC\nStates I-LOC\nsaid O\nit O\nhad O\nbeen O\ngranted O\nan O\noption O\nto O\nbuy O\nthe O\nnon-prescription O\nlens O\nproduction O\nunit O\nof O\nGentext B-ORG\nOptics I-ORG\nInc I-ORG\n, O\nan O\nEssilor B-ORG\nInternational I-ORG\nsubsidiary O\n. O\n\n-- O\nParis B-LOC\nnewsroom O\n+331 O\n4221 O\n5452 O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nSri B-MISC\nLankan I-MISC\nNewspapers O\n- O\nAugust O\n27 O\n. O\n\nFollowing O\nare O\nsome O\nof O\nthe O\nmain O\nstories O\nin O\nTuesday O\n's O\nSri B-MISC\nLankan I-MISC\nnewspapers O\n: O\n\n--- O\n\nVEERAKESARI B-ORG\n\nBomb O\nblast O\nin O\nTELO B-ORG\noffice O\nin O\nTrincomalee B-LOC\nkills O\none O\n, O\nwounds O\nsix O\n. O\n\nOne O\nofficer O\nand O\na O\nsoldier O\nkilled O\nin O\naccidental O\nclash O\nbetween O\ntwo O\ngroups O\nof O\nsoldiers O\nnear O\nChavakachcheri B-LOC\nin O\nJaffna B-LOC\n. O\n\nArmy O\nsentries O\nthought O\na O\ngroup O\nof O\nsoldiers O\napproaching O\nthem O\nwere O\nTamil B-MISC\nrebels O\nand O\nopened O\nfire O\n. O\n\n--- O\n\nTHINAKARAN B-ORG\n\nTULF O\nleader O\nM. B-PER\nSivasiththamparam I-PER\nsays O\nit O\nis O\nmeaningless O\nto O\ntalk O\nto O\nUNP B-ORG\nabout O\npeace O\npackage O\nand O\nthat O\nthe O\ngovernment O\nshould O\nsubmit O\npeace O\nplan O\nto O\nparliament O\nvery O\nsoon O\n. O\n\n--- O\n\nDAILY B-ORG\nNEWS I-ORG\n\nBread O\nand O\nflour O\nprices O\nhave O\nbeen O\nraised O\nwith O\nimmediate O\neffect O\nbut O\ngovernment O\nwill O\nprovide O\nrelief O\nto O\nunderpriviledged O\nsections O\nof O\nsociety O\n. O\n\n--- O\n\nTHE B-ORG\nISLAND I-ORG\n\nExcise O\nCommissioner O\nW.N.F. B-PER\nChandraratne I-PER\ndenies O\nallegations O\nthat O\nnew O\nguidelines O\nin O\nissue O\nof O\nliquor O\nlicences O\nare O\naimed O\nat O\nforcing O\nlarge O\nnumber O\nof O\nliquor O\nlicence O\nholders O\nout O\nof O\nbusiness O\nfor O\npolitical O\nreasons O\n. O\n\n--- O\n\nLANKADEEPA B-ORG\n\nTamil B-ORG\nTiger I-ORG\nrebels O\nhave O\nsent O\n12 O\nfemale O\nsuicide O\nbombers O\nto O\nstage O\nsimultaneous O\nattacks O\non O\nPresident O\nChandrika B-PER\nKumaratunga I-PER\n's O\nmotorcade O\nin O\nColombo B-LOC\n. O\n\n--- O\n\nDIVAINA B-ORG\n\nCultural O\nMinistry O\nplanning O\nto O\nspend O\nlarge O\nsum O\nof O\nmoney O\nto O\nbuy O\nsilver O\ncrown O\nbelieved O\nto O\nhave O\nbeen O\nworn O\nby O\nancient O\nking O\nand O\nnow O\nin O\nAustralia B-LOC\n. O\n\n--- O\n\nDINAMINA B-ORG\n\nGovernment O\ncloses O\nRuhunu B-ORG\nUniversity I-ORG\nindefinitely O\nafter O\nbig O\nclash O\nbetween O\ntwo O\ngroups O\nof O\nstudents O\nin O\nwhich O\neight O\nwere O\nwounded O\nand O\nhospitalised O\n. O\n\n-- O\nColombo B-LOC\nnewsroom O\ntel O\n941-434319 O\n\n-DOCSTART- O\n\nMother B-PER\nTeresa I-PER\nturns O\n86 O\nbut O\nstill O\nin O\ndanger O\n. O\n\nRupam B-PER\nBanerjee I-PER\n\nCALCUTTA B-LOC\n1996-08-27 O\n\nMother B-PER\nTeresa I-PER\nspent O\nher O\n86th O\nbirthday O\nin O\na O\nCalcutta B-LOC\nhospital O\nbed O\non O\nTuesday O\nas O\ntributes O\nto O\nthe O\nlegendary O\nmissionary O\npoured O\nin O\nfrom O\naround O\nthe O\nworld O\n. O\n\nDoctors O\nsaid O\nthat O\nlater O\nin O\nthe O\nday O\nthey O\nwould O\ntry O\nto O\nwean O\nthe O\nNobel B-MISC\nPeace I-MISC\nPrize I-MISC\nlaureate O\nfrom O\nthe O\nrespirator O\nthat O\nhas O\naided O\nher O\nbreathing O\nfor O\nthe O\npast O\nsix O\ndays O\n. O\n\n\" O\nHer O\ncondition O\nseems O\nto O\nbe O\nbetter O\n, O\nbut O\nthe O\ndanger O\nremains O\nas O\nlong O\nas O\nshe O\nis O\non O\nrespirator O\n, O\n\" O\nan O\nofficial O\nat O\nWoodlands B-LOC\nNursing I-LOC\nHome I-LOC\nsaid O\n. O\n\" O\n\nShe O\nis O\nconscious O\nbut O\nher O\nbreathing O\nis O\nirregular O\n. O\n\" O\n\nThe O\nrevered O\nRoman B-MISC\nCatholic I-MISC\nnun O\nwas O\nadmitted O\nto O\nthe O\nCalcutta B-LOC\nhospital I-LOC\na O\nweek O\nago O\nwith O\nhigh O\nfever O\nand O\nsevere O\nvomiting O\n. O\n\nShe O\nlater O\nsuffered O\nheart O\nfailure O\nand O\nwas O\ndiagnosed O\nwith O\nmalaria O\n. O\n\nHer O\nfever O\nhas O\nsince O\nabated O\nand O\nthe O\nheart O\nfailure O\nhas O\nbeen O\nbrought O\nunder O\ncontrol O\n, O\nbut O\nher O\nheart O\ncontinues O\nto O\nbeat O\nirregularly O\n, O\ndoctors O\nsaid O\n. O\n\n\" O\nUnless O\nshe O\nbreathes O\non O\nher O\nown O\n, O\nI O\nwould O\nadvise O\nyou O\nto O\nkeep O\nyour O\nfingers O\ncrossed O\n, O\n\" O\nsaid O\na O\ndoctor O\nwho O\nwas O\nfamiliar O\nwith O\nher O\ncase O\nbut O\nnot O\npart O\nof O\nthe O\nsix-member O\nteam O\ntreating O\nMother B-PER\nTeresa I-PER\n. O\n\nThe O\nnun O\n's O\nbirthday O\nprompted O\ngreetings O\n, O\nbouquets O\nand O\nprayers O\nfrom O\naround O\nthe O\nworld O\n. O\n\nPope B-PER\nJohn I-PER\nPaul I-PER\nII O\nand O\nIsraeli B-MISC\nForeign O\nMinister O\nDavid B-PER\nLevy I-PER\nsent O\nher O\nget-well O\nmessages O\n, O\nthe O\nPress B-ORG\nTrust I-ORG\nof I-ORG\nIndia I-ORG\nsaid O\n. O\n\n\" O\nAsk O\nfor O\na O\nmiracle O\n. O\n\nHappy O\nBirthday O\nto O\nour O\nDearest O\nMother O\n, O\n\" O\nread O\na O\nplacard O\nat O\nthe O\nShishu B-ORG\nBhavan I-ORG\nchildren O\n's O\nhome O\nin O\ncentral O\nCalcutta B-LOC\nrun O\nby O\nMother B-PER\nTeresa I-PER\n's O\nMissionaries B-ORG\nof I-ORG\nCharity I-ORG\n. O\n\nOn O\nMonday O\n, O\nboth O\nhouses O\nof O\nIndia B-LOC\n's O\nparliament O\nwished O\nthe O\nnation O\n's O\nadopted O\nsister O\na O\nhappy O\nbirthday O\nand O\nspeedy O\nrecovery O\nfrom O\nher O\nillness O\n. O\n\nPrayers O\ncontinued O\nin O\nCalcutta B-LOC\n, O\none O\nof O\nthe O\nworld O\n's O\npoorest O\ncities O\n, O\nwhere O\nMother B-PER\nTeresa I-PER\n's O\nMissionaries B-ORG\nof I-ORG\nCharity I-ORG\nruns O\nseveral O\nhomes O\nfor O\nthe O\npoor O\nand O\ndestitute O\n. O\n\nStreet O\nchildren O\n, O\nsome O\nof O\nthem O\nborn O\nto O\nprostitutes O\n, O\nheld O\nprayers O\non O\nthe O\nstreet O\n. O\n\" O\n\nAll O\nof O\nus O\nknow O\nabout O\nher O\n. O\n\nShe O\nis O\nlike O\na O\ngoddess O\n, O\n\" O\nsaid O\nRaju O\n, O\n8 O\n, O\nwho O\nhas O\na O\nmother O\nbut O\nno O\nfather O\n. O\n\nThe B-ORG\nStatesman I-ORG\nnewspaper O\nquoted O\n40-year-old O\nMangala B-PER\nDas I-PER\n, O\nparalysed O\nfrom O\nher O\nwaist O\ndown O\nand O\na O\nresident O\nof O\nthe O\nPrem B-ORG\nDan I-ORG\n( O\nGift B-ORG\nof I-ORG\nLove I-ORG\n) O\nhome O\nfor O\nthe O\ndestitute O\n, O\nas O\nsaying O\nshe O\nand O\nher O\nfriends O\nhad O\nbeen O\npraying O\nincessantly O\nfor O\nMother B-PER\nTeresa I-PER\n's O\nrecovery O\n. O\n\nTarak B-PER\nDas I-PER\n, O\n70 O\n, O\nwas O\npicked O\nup O\nfrom O\na O\nCalcutta B-LOC\nfootpath O\na O\nweek O\nago O\nby O\npassers-by O\nwho O\ntook O\npity O\non O\nhim O\nand O\nbrought O\nhim O\nto O\nNirmal B-LOC\nHriday I-LOC\n( O\nImmaculate O\nHome O\n) O\n. O\n\n\" O\nI O\ndo O\nnot O\nknow O\nwho O\nshe O\nis O\n. O\n\nI O\nhave O\nnever O\nseen O\nher O\n, O\nbut O\nI O\ncan O\nonly O\nbless O\nher O\nfor O\nwhat O\nshe O\nhas O\ndone O\nfor O\npeople O\nlike O\nme O\n, O\n\" O\nDas B-PER\ntold O\nThe B-ORG\nStatesman I-ORG\n. O\n\nMother B-PER\nTeresa I-PER\n's O\ncondition O\nimproved O\non O\nSunday O\nas O\nher O\nfever O\nabated O\n, O\nand O\non O\nMonday O\nshe O\nwas O\nable O\nto O\nscribble O\nnotes O\nto O\ndoctors O\nand O\nnuns O\n. O\n\nThousands O\nin O\nCalcutta B-LOC\n, O\nwhere O\nshe O\nfounded O\nher O\nMissionaries B-ORG\nof I-ORG\nCharity I-ORG\nreligious O\norder O\nin O\n1949 O\n, O\nprayed O\nfor O\nher O\nrecovery O\n. O\n\nMinisters O\nof O\nthe O\ncommunist O\ngovernment O\nof O\nWest B-LOC\nBengal I-LOC\nstate O\nand O\npeople O\nof O\ndifferent O\nreligions O\njoined O\nCatholics B-MISC\nto O\npray O\nfor O\nMother B-PER\nTeresa I-PER\n's O\nrecovery O\nat O\nMother B-LOC\nHouse I-LOC\n. O\n\n\" O\nWe O\njoined O\nthe O\nprayer O\nto O\nexpress O\nour O\nsolidarity O\nwith O\nher O\nwork O\nfor O\nthe O\ncause O\nof O\nthe O\npoor O\nand O\ndowntrodden O\n, O\n\" O\nsaid O\nNanda B-PER\nGopal I-PER\nBhattacharya I-PER\n, O\na O\ncommunist O\nminister O\nin O\nWest B-LOC\nBengal I-LOC\n. O\n\n-DOCSTART- O\n\nIslamists B-MISC\ncan O\nmeet O\nin O\nLondon B-LOC\n, O\nminister O\n. O\n\nISLAMABAD B-LOC\n1996-08-27 O\n\nBritish B-MISC\nForeign O\nSecretary O\nMalcolm B-PER\nRifkind I-PER\nsaid O\non O\nTuesday O\nthat O\nhis O\ngovernment O\nwould O\nonly O\ntake O\naction O\nagainst O\na O\nplanned O\nconference O\nof O\nIslamist B-MISC\ngroups O\nin O\nLondon B-LOC\nif O\nBritish B-MISC\nlaw O\nwas O\nbroken O\n. O\n\n\" O\nPeople O\nwho O\nwish O\nto O\nhold O\nconferences O\nof O\ncourse O\ndo O\nn't O\nneed O\nto O\nseek O\npermission O\nfrom O\nthe O\ngovernment O\nin O\nBritain B-LOC\n, O\n\" O\nRifkind B-PER\n, O\nin O\nPakistan B-LOC\nfor O\na O\nvisit O\n, O\ntold O\nReuters B-ORG\n. O\n\" O\n\nAs O\nlong O\nas O\nthey O\nobey O\nour O\nlaws O\nthen O\nthat O\nis O\nnot O\nsomething O\nthe O\ngovernment O\nwould O\nnormally O\ninterfere O\nwith O\n. O\n\" O\n\nThe O\nIslamist B-MISC\nconference O\n, O\ndue O\nto O\nbe O\nheld O\nin O\nLondon B-LOC\non O\nSeptember O\n8 O\n, O\nhas O\ncaused O\nconcern O\nin O\ncountries O\nsuch O\nas O\nAlgeria B-LOC\nand O\nEgypt B-LOC\n, O\nwhich O\nare O\nfighting O\narmed O\nIslamic B-MISC\nmilitants O\n. O\n\nBritish B-MISC\nJewish B-MISC\ngroups O\nhave O\nalso O\nprotested O\nbecause O\nthey O\nsay O\nmembers O\nof O\nAlgeria B-LOC\n's O\nIslamic B-ORG\nSalvation I-ORG\nFront I-ORG\n( O\nFIS B-ORG\n) O\nand O\nthe O\nPalestinian B-MISC\nIslamic B-MISC\ngroup O\nHamas B-ORG\nare O\non O\nthe O\nguest O\nlist O\n. O\n\nRifkind B-PER\nsaid O\nit O\nwas O\nfor O\nthe O\nhome O\nsecretary O\n( O\ninterior O\nminister O\n) O\nto O\nact O\nby O\ndenying O\nvisas O\nto O\nparticipants O\nif O\nhe O\nfelt O\nthere O\nwas O\nreason O\nto O\nbelieve O\nthat O\nthey O\nmight O\nbreak O\nthe O\nlaw O\n. O\n\n\" O\nOur O\npolicy O\nhas O\nto O\nbe O\nfundamentally O\nbased O\non O\nrespect O\nfor O\nthe O\nrule O\nof O\nlaw O\nand O\ninsistence O\nthat O\nit O\nbe O\nobserved O\n, O\n\" O\nhe O\nsaid O\n. O\n\nRifkind B-PER\nwas O\nin O\nPakistan B-LOC\nat O\nthe O\nstart O\nof O\nan O\nAsian B-MISC\ntour O\nthat O\nwill O\nalso O\ntake O\nhim O\nto O\nIndia B-LOC\n, O\nSri B-LOC\nLanka I-LOC\n, O\nJapan B-LOC\nand O\nMongolia B-LOC\n. O\n\n-DOCSTART- O\n\nAfghan B-MISC\nleader O\ntells O\nU.S. B-LOC\nCongressman O\nof O\npeace O\nplan O\n. O\n\nSayed B-PER\nSalahuddin I-PER\n\nKABUL B-LOC\n1996-08-27 O\n\nAfghan B-MISC\ngovernment O\nmilitary O\nchief O\nAhmad B-PER\nShah I-PER\nMasood I-PER\nbriefed O\nvisiting O\nU.S. B-LOC\nCongressman O\nDana B-PER\nRohrabacher I-PER\non O\nTuesday O\non O\na O\npeace O\nplan O\nfor O\nhis O\nwartorn O\ncountry O\n. O\n\nA O\nspokesman O\nfor O\nMasood B-PER\nsaid O\nhe O\nhad O\ntold O\nthe O\nCalifornia B-LOC\nRepublican B-MISC\nat O\na O\nmeeting O\nin O\nnorthern O\nKabul B-LOC\nthat O\nPresident O\nBurhanuddin B-PER\nRabbani I-PER\n's O\ngovernment O\nfavoured O\ntalks O\nwith O\nall O\nAfghan B-MISC\nfactions O\nto O\nset O\nup O\nan O\ninterim O\ngovernment O\n. O\n\nThe O\nfactions O\nshould O\nagree O\nto O\nappoint O\na O\ntransitional O\nleader O\n, O\ndraft O\na O\nnew O\nconstitution O\n, O\ncollect O\nheavy O\nweapons O\n, O\ncreate O\na O\nnational O\narmy O\nand O\nhold O\nfree O\nelections O\nin O\nwhich O\nthe O\ntransitional O\nleader O\nwould O\nbe O\nbarred O\nfrom O\nstanding O\n, O\nhe O\nadded O\n. O\n\nRohrabacher B-PER\nflew O\ninto O\nBagram B-LOC\nmilitary O\nairbase O\nnorth O\nof O\nKabul B-LOC\nin O\na O\nRed B-ORG\nCross I-ORG\nplane O\non O\nTuesday O\nafter O\nmeeting O\nnorthern O\nopposition O\nmilitia O\nleader O\nGeneral O\nAbdul B-PER\nRashid I-PER\nDostum I-PER\n. O\n\nMasood B-PER\n's O\nspokesman O\nAmrollah B-PER\n( O\none O\nname O\n) O\nsaid O\nRohrabacher B-PER\nhad O\nrecently O\nvisited O\nItaly B-LOC\n, O\nSaudi B-LOC\nArabia I-LOC\nand O\nPakistan B-LOC\nas O\npart O\nof O\na O\nmission O\nto O\npromote O\npeace O\nin O\nAfghanistan B-LOC\n. O\n\n\" O\nWe O\nare O\ncertainly O\nserious O\nmore O\nthan O\nbefore O\nto O\nfind O\na O\nsolution O\nto O\nthe O\nAfghan B-MISC\nproblem O\nand O\nsupport O\nevery O\nU.N. B-ORG\nplan O\n, O\n\" O\nAmrollah B-PER\nquoted O\nRohrabacher B-PER\nas O\nsaying O\n. O\n\nHowever O\n, O\na O\nspokesman O\nfor O\nPrime O\nMinister O\nGulbuddin B-PER\nHekmatyar I-PER\n, O\na O\nlong-time O\nrival O\nof O\nMasood B-PER\n, O\nexpressed O\nconcern O\nat O\nsigns O\nof O\nrenewed O\nU.S. B-LOC\ninterest O\nin O\nAfghanistan B-LOC\n. O\n\n\" O\nAmerica B-LOC\nwants O\nto O\nblock O\nthe O\nestablishment O\nof O\na O\nstrong O\nIslamic B-MISC\ngovernment O\nin O\nAfghanistan B-LOC\nand O\nthe O\nU.S. B-LOC\nintends O\nto O\nneutralise O\nthe O\nAfghan B-MISC\npeace O\nprocess O\ninitiated O\nby O\nthe O\nAfghans B-MISC\nthemselves O\n, O\n\" O\nsaid O\nthe O\nspokesman O\n, O\nHamid B-PER\nIbrahimi I-PER\n. O\n\n\" O\nA O\ngreat O\ngame O\nhas O\nbeen O\nstarted O\nin O\nAfghanistan B-LOC\nas O\nAmerica B-LOC\nfeels O\nthat O\nTehran B-LOC\nand O\nMoscow B-LOC\nhave O\ngot O\nstronger O\nin O\nthe O\nAfghan B-MISC\npicture O\n-- O\nsomething O\nWashington B-LOC\nwants O\nto O\nchange O\n, O\n\" O\nhe O\nsaid O\n. O\n\nRohrabacher B-PER\nwas O\nexpected O\nto O\nvisit O\nneutral O\nfaction O\nleaders O\nin O\nthe O\neastern O\ncity O\nof O\nJalalabad B-LOC\nand O\nmeet O\nleaders O\nof O\nthe O\nrebel O\nIslamic B-MISC\nTaleban I-MISC\nmilitia O\nin O\nthe O\nsouthern O\ncity O\nof O\nKandahar B-LOC\n. O\n\nAfghan B-MISC\nguerrilla O\nfactions O\nhave O\nbeen O\nlocked O\nin O\na O\nbloody O\npower O\nstruggle O\nsince O\nthe O\nfall O\nof O\nthe O\ncommunist O\ngovernment O\nin O\nApril O\n1992 O\n. O\n\nHekmatyar B-PER\n, O\nonce O\nRabbani B-PER\n's O\nmain O\nrival O\n, O\nmade O\na O\npeace O\npact O\nwith O\nhim O\nand O\nrejoined O\nthe O\ngovernment O\nas O\nprime O\nminister O\nin O\nJune O\n. O\n\n-DOCSTART- O\n\nPakistan B-LOC\nstate O\nbank O\nsells O\n1.38 O\nbln O\nrupees O\nof O\nbonds O\n. O\n\nKARACHI B-LOC\n, O\nPakistan B-LOC\n1996-08-27 O\n\nThe O\nState B-ORG\n( I-ORG\ncentral I-ORG\n) I-ORG\nBank I-ORG\nof O\nPakistan B-LOC\nauctioned O\nthree- O\n, O\nfive- O\nand O\n10-year O\nfederal O\ninvestment O\nbonds O\nworth O\n1.38 O\nbillion O\nrupees O\non O\nTuesday O\n. O\n\nThe O\nbank O\nsaid O\nit O\nhad O\naccepted O\nbids O\nof O\n250 O\nmillion O\nrupees O\nat O\npar O\nfor O\nthree-year O\nbonds O\n, O\n3.5 O\nmillion O\nrupees O\nat O\npar O\nfor O\nfive-year O\nbonds O\nand O\n1.126 O\nbillion O\nat O\npar O\nfor O\n10-year O\nbonds O\n. O\n\nThe O\nauction O\nis O\nset O\nfor O\nsettlement O\non O\nThursday O\n. O\n\nIn O\nthe O\nprevious O\nauction O\non O\nJuly O\n11 O\n, O\nit O\naccepted O\nbids O\nworth O\n300 O\nmillion O\nrupees O\nat O\npar O\nfor O\nthree-year O\nbonds O\n, O\n44.5 O\nmillion O\nrupees O\nat O\npar O\nfor O\nfive-year O\nbonds O\nand O\n782.6 O\nmillion O\nrupees O\nat O\npar O\nfor O\n10-year O\nbonds O\n. O\n\n-- O\nKarachi B-LOC\nnewsroom O\n9221-5685192 O\n\n-DOCSTART- O\n\nNepal B-LOC\noffers O\nto O\ntalk O\nto O\nMaoist B-MISC\ninsurgents O\n. O\n\nGopal B-PER\nSharma I-PER\n\nKATHMANDU B-LOC\n1996-08-27 O\n\nNepal B-LOC\n's O\ncentre-right O\ncoalition O\ngovernment O\nhas O\noffered O\nto O\nmeet O\nthe O\ncountry O\n's O\nhardline O\nMaoist B-MISC\ncommunists O\nfor O\ntalks O\nin O\na O\nbid O\nto O\nend O\nan O\ninsurgency O\nin O\nNepal B-LOC\n's O\nwestern O\ndistricts O\n, O\nofficials O\nsaid O\non O\nTuesday O\n. O\n\nThe O\nMaoists B-MISC\noppose O\nmulti-party O\ndemocracy O\nand O\nwant O\nto O\nestablish O\na O\ncommunist O\nstate O\n. O\n\nBut O\nthe O\nNepali B-MISC\ngovernment O\nsaid O\nthe O\ninsurgents O\nmust O\ngive O\nup O\nviolence O\nbefore O\nit O\nnegotiates O\nwith O\nthem O\n. O\n\n\" O\nThey O\n( O\nthe O\ninsurgents O\n) O\nshould O\nfirst O\ngive O\nup O\ntheir O\nviolent O\nactivities O\n, O\n\" O\nHome O\n( O\nInterior O\n) O\nMinister O\nKhum B-PER\nBahadur I-PER\nKhadga I-PER\nsaid O\n. O\n\nAbout O\n54 O\npeople O\nhave O\ndied O\nin O\nMaoist B-MISC\ninsurgent O\nactivity O\nand O\nin O\npolice O\naction O\nagainst O\nthem O\nsince O\nFebruary O\n, O\nofficials O\nsaid O\n. O\n\nNepali B-MISC\nopposition O\nparties O\nhave O\naccused O\nthe O\npolice O\nof O\nhaving O\nkilled O\nmore O\npeople O\nthan O\nthe O\ninsurgents O\n. O\n\nSome O\nhuman O\nrights O\ngroups O\nhave O\ncriticised O\nthe O\ngovernment O\n's O\nhandling O\nof O\nthe O\nsituation O\n. O\n\nIn O\na O\nspeech O\nin O\nparliament O\non O\nTuesday O\n, O\nKhadga B-PER\nchallenged O\nthe O\nMaoist B-MISC\ncommunists O\nto O\n\" O\nwin O\nthe O\npeople O\n's O\nconfidence O\n\" O\nand O\nwin O\nelection O\nto O\nparliament O\n. O\n\nOn O\nMonday O\n, O\nhe O\nhad O\noffered O\nto O\ntalk O\nto O\nleaders O\nof O\nthe O\nUnited B-ORG\nPeople I-ORG\n's I-ORG\nFront I-ORG\nNepal I-ORG\n( O\nBhattarai B-ORG\n) O\n, O\nthe O\nMaoist B-MISC\nfaction O\nwhich O\nleads O\nthe O\ninsurgency O\n. O\n\n\" O\nThe O\ngovernment O\nis O\nready O\nto O\nguarantee O\nsecurity O\nof O\nthe O\nMaoist B-MISC\nrepresentatives O\nwho O\nwant O\nto O\ntake O\npart O\nin O\npeaceful O\ndialogue O\n, O\n\" O\nKhadga B-PER\nsaid O\n. O\n\nA O\nmulti-party O\ndemocracy O\nwas O\nset O\nup O\nin O\nNepal B-LOC\nsix O\nyears O\nago O\n, O\nafter O\na O\npopular O\nmovement O\nby O\nthe O\ncentrist O\nNepali B-ORG\nCongress I-ORG\nparty O\njointly O\nwith O\nthe O\nCommunist B-ORG\nUnited I-ORG\nMarxist-Leninist I-ORG\n( O\nUML B-ORG\n) O\nparty O\n. O\n\nThe O\nNepali B-ORG\nCongress I-ORG\nleads O\nthe O\nthree-party O\ncoalition O\ngovernment O\nwhile O\nthe O\nUML B-ORG\nis O\nthe O\nmain O\nopposition O\nparty O\n. O\n\n-DOCSTART- O\n\nIndian B-MISC\nsoy O\nprices O\nend O\nsteady O\nahead O\nof O\nholiday O\n. O\n\nINDORE B-LOC\n, O\nIndia B-LOC\n1996-08-27 O\n\nIndian B-MISC\nsoybean O\nprices O\non O\nTuesday O\nremained O\nsteady O\nat O\n12,900-13,100 O\nrupees O\nper O\ntonne O\nin O\nplant O\ndelivery O\ncondition O\n, O\ndealers O\nsaid O\n\nThey O\nsaid O\narrivals O\nwere O\npoor O\ndue O\nto O\nthe O\nfestival O\nseason O\n. O\n\nMarkets O\nin O\ncentral O\nIndia B-LOC\nwould O\nbe O\nclosed O\nfor O\na O\nlocal O\nreligious O\nholiday O\non O\nWednesday O\n. O\n\nSoyoil O\nprices O\nfell O\non O\nincreased O\nselling O\nagainst O\npoor O\ndemand O\n. O\n\nSoyoil O\nsolvent O\nwas O\ndown O\nby O\n400 O\nrupees O\nper O\ntonne O\nand O\nsoyoil O\nrefined O\nwas O\ndown O\nby O\n400 O\nrupees O\n. O\n\nSoyoil O\nrefined O\nfell O\nby O\n200 O\nrupees O\non O\nweak O\nundertone O\n. O\n\nSoymeal O\nyellow O\nwas O\n$ O\n276-277 O\nand O\nsoymeal O\nblack O\nwas O\n$ O\n246-248 O\nper O\ntonne O\nin O\nexport O\n. O\n\nRapeseed O\nextraction O\nwas O\n$ O\n115 O\nper O\ntonne O\nin O\nexport O\n. O\n\nExport O\ndemand O\nwas O\ngood O\nbut O\navailability O\nwas O\nlimited O\n. O\n\nRapeseed O\nextraction O\nwas O\n3,850 O\nrupees O\nFOR O\nBedibunder B-ORG\nand O\nwas O\n3,800-3,825 O\nrupees O\nFOR O\nBhavnagar B-ORG\n. O\n\n--------------------- O\n\n( O\nPrices O\nin O\nrupees O\nper O\ntonne O\n) O\n\nMarket O\nArrivals O\nAuction O\nTraders O\nPlant O\n\n( O\nin O\ntonnes O\n) O\n\nDewas B-LOC\n45 O\nYellow O\n12,700-12,950 O\n12,900-13,150 O\n12,900-13,100 O\n\nBlack B-LOC\n11,900-12,100 O\n\nMandsaur B-LOC\n10 O\nYellow O\n12,600-12,750 O\n12,700-12,850 O\n\nNeemuch B-LOC\nn.a O\nYellow O\n- O\n- O\n\nMhow B-LOC\n2 O\nYellow O\n12,700-12,800 O\n12,750-12,850 O\n\nRatlam B-LOC\n10 O\nYellow O\n12,600-12,750 O\n12,700-12,800 O\n\nAshta B-LOC\n10 O\nYellow O\n12,700-12,900 O\n12,800-13,000 O\n\nIndore B-LOC\n25 O\nYellow O\n12,750-12,950 O\n12,900-13,100 O\n\nDhar B-LOC\n5 O\nYellow O\n12,700-12,800 O\n12,750-12,900 O\n\nUjjain B-LOC\n8 O\nYellow O\n12,750-12,900 O\n12,850-13,050 O\n\nJaora B-LOC\nn.a O\nYellow O\n- O\n- O\n\nBarnagar B-LOC\nn.a O\nYellow O\n- O\n- O\n\nKhandwa B-LOC\nn.a O\nYellow O\n- O\n- O\n\nAshoknagar B-LOC\nn.a O\nYellow O\n- O\n- O\n\nNalkhera B-LOC\nn.a O\nYellow O\n- O\n- O\n\n---------------------------------- O\n\nSoyoil O\n( O\nin O\nrupees O\nper O\ntonne O\n) O\n\nSoyoil O\nsolvent O\nplant O\ndelivery O\n30,300-30,400 O\n\nSoyoil O\nsolvent O\nmarket O\ndelivery O\n30,700-30,800 O\n\nSoyoil O\nrefined O\nplant O\ndelivery O\n32,700-32,800 O\n\nSoyoil O\nrefined O\nmarket O\ndelivery O\n32,900-33,000 O\n\n-------------------------------- O\n\nSoymeal O\n( O\nin O\nrupees O\nper O\ntonne O\n, O\nfree O\non O\nrail-FOR O\n) O\n\nYellow B-MISC\nBlack I-MISC\n\nFOR O\nBombay B-MISC\n9,800 O\n8,800 O\n\nFOR O\nBedi B-MISC\nBunder I-MISC\n9,800 O\n8,800 O\n\n( O\n$ O\n1=35.73 O\nrupees O\n) O\n\n-DOCSTART- O\n\nBangladesh B-LOC\nSpeaker O\nsays O\nhe O\nreceived O\ndeath O\nthreats O\n. O\n\nDHAKA B-LOC\n1996-08-27 O\n\nThe O\nSpeaker O\nof O\nBangladesh B-LOC\n's O\nparliament O\n, O\nHumayun B-PER\nRasheed I-PER\nChoudhury I-PER\n, O\nsaid O\nhe O\nhad O\nreceived O\ndeath O\nthreats O\nfrom O\nanonymous O\ncallers O\nafter O\nopposition O\nparties O\nthreatened O\nto O\nboycott O\nproceedings O\nchaired O\nby O\nhim O\n. O\n\nHe O\ntold O\nthe O\nBengali B-MISC\nnewspaper O\nBanglabazar B-ORG\nPatrika I-ORG\non O\nTuesday O\nthat O\nsuch O\nthreats O\nwere O\npossibly O\ncoming O\nfrom O\n\" O\nthose O\nwho O\nwant O\nto O\npush O\nthe O\ncountry O\ninto O\nchaos O\nand O\nunrest O\n. O\n\" O\n\nThe O\ncallers O\nsaid O\nhis O\nlife O\ncould O\nbe O\ncut O\nshort O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nThe O\nspeaker O\nwas O\nnot O\nimmediately O\navailable O\nfor O\ncomment O\n. O\n\nChoudhury B-PER\n, O\na O\nformer O\nforeign O\nminister O\nand O\nveteran O\ndiplomat O\n, O\nwas O\nappointed O\nspeaker O\nof O\nthe O\n330-member O\nparliament O\non O\nJuly O\n13 O\n, O\na O\nmonth O\nafter O\ngeneral O\nelections O\nreturned O\nthe O\nAwami B-ORG\nLeague I-ORG\nof O\nPrime O\nMinister O\nSheikh O\nHasina B-PER\nto O\npower O\nafter O\n21 O\nyears O\n. O\n\nChoudhury B-PER\nalso O\nwas O\npresident O\nof O\nthe O\n41st O\nsession O\nof O\nthe O\nU.N. B-ORG\nGeneral I-ORG\nAssembly I-ORG\nin O\n1986-87 O\n. O\n\nFormer O\nprime O\nminister O\nBegum B-PER\nKhaleda I-PER\nZia I-PER\n, O\nnow O\nthe O\nopposition O\nleader O\nin O\nparliament O\nand O\nhead O\nof O\nthe O\nBangladesh B-ORG\nNationalist I-ORG\nParty I-ORG\n( O\nBNP B-ORG\n) O\n, O\nsaid O\nher O\nfollowers O\nmight O\nboycott O\nassemby O\nsessions O\nchaired O\nby O\nthe O\n\" O\npartisan O\n\" O\nspeaker O\n. O\n\n\" O\nThe O\nruling O\nAwami O\nleague O\nis O\nmaking O\nparliament O\nineffective O\nand O\nthe O\nspeaker O\nis O\ncontributing O\nto O\nthat O\nby O\nnot O\nallowing O\nthe O\nopposition O\nMPs O\nenough O\ntime O\nto O\nspeak O\n, O\n\" O\nshe O\ntold O\na O\nrally O\nin O\nnorthern O\ndistrict O\nof O\nBogra B-LOC\non O\nMonday O\n. O\n\nHasina B-PER\n, O\nspeaking O\nto O\na O\ngroup O\nof O\nengineers O\nin O\nDhaka B-LOC\non O\nMonday O\n, O\naccused O\nthe O\nBNP B-ORG\nof O\nresorting O\nto O\n\" O\nterrorism O\n\" O\nas O\npart O\nof O\nits O\nplan O\nto O\ncreate O\ninstability O\nand O\nchaos O\nin O\nthe O\ncountry O\n. O\n\n\" O\nThis O\nis O\nnot O\ndesireable O\n... O\n\nand O\nwe O\nwill O\ndeal O\nwith O\nsuch O\ndesigns O\nsternly O\n, O\n\" O\nthe O\nprime O\nminister O\nsaid O\n. O\n\n-DOCSTART- O\n\nBangladesh B-LOC\nJune O\nM2 O\nup O\n3.8 O\npct O\nm O\n/ O\nm O\n, O\nup O\n8.2 O\npct O\ny O\n/ O\ny O\n. O\n\nDHAKA B-LOC\n1996-08-27 O\n\nBangladesh B-LOC\n's O\nM2 O\nmoney O\nsupply O\nrose O\n3.8 O\npercent O\nin O\nJune O\nto O\n456.8 O\nbillion O\ntaka O\nafter O\na O\n0.27 O\npercent O\nrise O\nto O\n439.9 O\nbillion O\nin O\nMay O\n, O\ncentral O\nbank O\nofficials O\nsaid O\n. O\n\nThe O\nyear-on-year O\nrise O\nwas O\n8.2 O\npercent O\nto O\nJune O\n, O\n1996 O\n. O\n\nBANGLADESH B-LOC\n'S O\nMONEY O\nSUPPLY O\n\nJUNE O\nMAY O\nJUNE O\n1995 O\n\nM2 O\nmoney O\nsupply O\n( O\nbln O\ntaka O\n) O\n456.8 O\n439.9 O\n422.1 O\n\nM1 O\nmoney O\nsupply O\n( O\nbln O\ntaka O\n) O\n144.5 O\n139.3 O\n131.7 O\n\n-DOCSTART- O\n\nHELIBOR B-MISC\nINTEREST O\nRATES O\nLARGELY O\nUNCHANGED O\n. O\n\nHELSINKI B-LOC\n1996-08-27 O\n\nHelibor B-MISC\nmarket O\ninterest O\nrates O\n\nwere O\nlargely O\nunchanged O\nat O\nthe O\nBank B-ORG\nof I-ORG\nFinland I-ORG\n's O\ndaily O\nfixing O\non O\n\nTuesday O\n. O\n\nThe O\nkey O\nthree-month O\nrate O\nwas O\nsteady O\nat O\n3.40 O\npercent O\n. O\n\nAugust O\n27 O\nfix O\nAugust O\n26 O\nfix O\n\n1-mth O\nHelibor B-MISC\n3.27 O\npct O\n3.29 O\npct O\n\n2-mth O\nHelibor B-MISC\n3.34 O\npct O\n3.34 O\npct O\n\n3-mth O\nHelibor B-MISC\n3.40 O\npct O\n3.40 O\npct O\n\n6-mth O\nHelibor B-MISC\n3.56 O\npct O\n3.55 O\npct O\n\n9-mth O\nHelibor B-MISC\n3.73 O\npct O\n3.70 O\npct O\n\n12-mth O\nHelibor B-MISC\n3.89 O\npct O\n3.87 O\npct O\n\n-- O\nHelsinki B-LOC\nnewsroom O\n+358 O\n- O\n0 O\n- O\n680 O\n50 O\n248 O\n\n-DOCSTART- O\n\nBarrick B-ORG\ngets O\n93 O\npct O\nof O\nArequipa B-ORG\n. O\n\nTORONTO B-LOC\n1996-08-27 O\n\nBarrick B-ORG\nGold I-ORG\nCorp I-ORG\nsaid O\non O\nTuesday O\nits O\ntakeover O\noffer O\nfor O\nArequipa B-ORG\nResources I-ORG\nLtd I-ORG\nwas O\nsuccessful O\n, O\nwith O\n93 O\npercent O\nof O\nthe O\n36.3 O\nmillion O\nshares O\nnot O\nalready O\nowned O\ntendered O\nunder O\nthe O\nbid O\n, O\nwhich O\nexpired O\novernight O\n. O\n\n\" O\nWe O\nare O\npleased O\nthat O\nArequipa B-ORG\nshareholders O\nahave O\nchosen O\nso O\noverwhelmingly O\nto O\naccept O\nthis O\noffer O\n. O\n\nWe O\nnow O\nhave O\nthe O\nopportunity O\nto O\nrealize O\nthe O\npotential O\nof O\nArequipa B-ORG\n's O\nexcellent O\nassets O\n, O\n\" O\nBarrick B-ORG\nchairman O\nand O\nchief O\nexecutive O\nPeter B-PER\nMunk I-PER\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nC$ B-MISC\n30-a-share O\ndeal O\nmeans O\nBarrick B-ORG\nwill O\nown O\nArequipa B-ORG\n's O\nattractive O\nPierina B-LOC\ngold O\ndeposit O\nin O\nPeru B-LOC\n. O\n\nBarrick B-ORG\nsaid O\ndetails O\ninvolving O\nthe O\nallocation O\nbetween O\nBarrick B-ORG\nshares O\nand O\ncash O\nwill O\nbe O\navailable O\nshortly O\n. O\n\nBarrick B-ORG\n's O\noffer O\nof O\nC$ B-MISC\n30 O\na O\nshare O\nor O\npart O\ncash O\n, O\npart O\nshare O\noffer O\nwas O\nBarrick B-ORG\n's O\nsecond O\nattempt O\nto O\nswallow O\nthe O\nsmall O\nVancouver-based B-MISC\ngold O\nprospector O\n. O\n\nToronto-based B-MISC\nBarrick B-ORG\n, O\nthe O\nworld O\n's O\nthird O\nlargest O\ngold O\nproducer O\n, O\nsweetened O\nits O\nJuly O\n11 O\nbid O\nto O\nC$ B-MISC\n30 O\na O\nshare O\nfrom O\nC$ B-MISC\n27 O\non O\nAugust O\n16 O\nafter O\na O\nfresh O\nbatch O\nof O\ndrill O\nresults O\nfrom O\nthe O\nPierina B-LOC\ndeposit O\n. O\n\nExperts O\nhave O\nspeculated O\nthe O\ndeposit O\nhas O\npotential O\nreserves O\nof O\nup O\nto O\n12 O\nmillion O\nounces O\n. O\n\nMore O\ndrilling O\nresults O\nare O\nexpected O\nsoon O\n. O\n\nThe O\nBarrick B-ORG\nbid O\ntook O\nobservers O\nby O\nsurprise O\n, O\nsince O\nArequipa B-ORG\n's O\nexploration O\nwas O\nstill O\nin O\nits O\nearly O\nstages O\n. O\n\nArequipa B-ORG\nshareholders O\nhad O\nthe O\noption O\nto O\nchoose O\nC$ B-MISC\n30 O\ncash O\nor O\n0.79 O\nBarrick B-ORG\nshares O\nplus O\n50 O\ncents O\nfor O\neach O\nArequipa B-ORG\nshare O\n. O\n\nShares O\nwere O\nto O\nbe O\npro-rated O\nif O\nmore O\nthan O\n14.4 O\nmillion O\nwere O\nrequested O\n. O\n\n-- O\nReuters B-ORG\nToronto I-ORG\nBureau I-ORG\n416 O\n941-8100 O\n\n-DOCSTART- O\n\nPenn B-ORG\nTreaty I-ORG\nterminates O\nacquisition O\npact O\n. O\n\nALLENTOWN B-LOC\n, O\nPa B-LOC\n. O\n\n1996-08-27 O\n\nPenn B-ORG\nTreaty I-ORG\nAmerican I-ORG\nCorp I-ORG\nsaid O\nTuesday O\nit O\nterminated O\na O\npreviously O\nannounced O\nnon-binding O\nletter O\nof O\nintent O\nto O\npurchase O\nMerrion B-ORG\nInsurance I-ORG\nCompany I-ORG\nInc I-ORG\n, O\na O\nNew B-LOC\nYork I-LOC\nlicensed O\ncompany O\n. O\n\nIn O\nannouncing O\nits O\ndecision O\n, O\nPenn B-ORG\nTreaty I-ORG\nsaid O\nit O\n\" O\nwill O\ncontinue O\nto O\nactively O\npursue O\nentering O\ninto O\nthe O\nNew B-LOC\nYork I-LOC\nlong-term O\ncare O\nmarket O\nthrough O\nlicensing O\nor O\nby O\nacquisition O\n. O\n\" O\n\nIt O\nexplained O\nthe O\n\" O\naddition O\nof O\na O\nNew B-LOC\nYork I-LOC\nlicense O\nwill O\nenable O\nPenn B-ORG\nTreaty I-ORG\nAmerican I-ORG\nCorp I-ORG\nto O\nconduct O\nbusiness O\nin O\nall O\n50 O\nstates O\n, O\nfollowing O\nthe O\ncompany O\n's O\nacquisition O\nof O\nHealth B-ORG\nInsurance I-ORG\nof I-ORG\nVermont I-ORG\n, O\na O\nVermont B-LOC\ndomiciled O\ninsurer O\n, O\nscheduled O\nto O\nclose O\non O\nAugust O\n30 O\n, O\n1996 O\n. O\n\" O\n\n-- O\nNew B-ORG\nYork I-ORG\nNewsdesk I-ORG\n212-859-1610 O\n. O\n\n-DOCSTART- O\n\nVNU B-ORG\ndetails O\nfirst-half O\noperating O\nprofits O\n. O\n\nHAARLEM B-LOC\n, O\nNetherlands B-LOC\n1996-08-27 O\n\nPublisher O\nVNU B-ORG\ngave O\nthe O\nfollowing O\nbreakdown O\nof O\nits O\nfirst-half O\nresults O\n: O\n\nH1 O\n1996 O\nH1 O\n1995 O\n\nSales O\nOp O\nprofit O\nSales O\nOp O\nprofit O\n\nConsumer O\nmagazines O\n618 O\n90 O\n568 O\n80 O\n\nNewspapers O\n363 O\n49 O\n295 O\n46 O\n\nCommercial O\nTV O\n127 O\n6 O\nloss O\n174 O\n33 O\nprofit O\n\nBusiness O\ninfo O\nEurope B-LOC\n231 O\n24 O\n178 O\n18 O\n\nBusiness O\ninfo O\nUSA B-LOC\n382 O\n61 O\n362 O\n41 O\n\nEducation O\n42 O\n6 O\n36 O\n3 O\n\nMiscellaneous O\ncharges O\n--- O\n16 O\n--- O\n30 O\n\nNOTES O\n- O\nSales O\nand O\noperating O\nprofit O\nare O\ngiven O\nin O\nmillions O\nof O\nguilders O\n. O\n\nCommercial O\nTV O\nincludes O\npro O\nrata O\nshare O\nof O\nsales O\nand O\noperating O\nprofits O\nin O\nDutch B-MISC\ngroup O\nHMG B-ORG\nand O\nBelgium B-LOC\n's O\nVTM B-ORG\n. O\n\n-- O\nAmsterdam B-LOC\nnewsroom O\n+31 O\n20 O\n504 O\n5000 O\n, O\nFax O\n+31 O\n20 O\n504 O\n5040 O\n\n-DOCSTART- O\n\nAOL B-ORG\nEurope I-ORG\nforms O\nonline O\nadvertising O\nagency O\n. O\n\nHANOVER B-LOC\n, O\nGermany B-LOC\n1996-08-27 O\n\nThe O\njoint O\nventure O\nbetween O\nAmerica B-ORG\nOnline I-ORG\n( O\nAOL B-ORG\n) O\nand O\nBertelsmann B-ORG\nAG I-ORG\nhas O\nformed O\na O\nnew O\ncompany O\nto O\nsell O\nadvertising O\nspace O\non O\nAOL B-ORG\nin O\nEurope B-LOC\n, O\na O\nBertelsmann B-ORG\nofficial O\nsaid O\non O\nTuesday O\n. O\n\nThe O\nnew O\ncompany O\nis O\ncalled O\nAdOn B-ORG\nGmbH I-ORG\nand O\nis O\nlocated O\nin O\nHamburg B-LOC\n, O\nBernd B-PER\nSchiphorst I-PER\n, O\npresident O\nand O\nchief O\noperating O\nofficer O\nof O\nBertelsmann B-ORG\n's O\nNew B-ORG\nMedia I-ORG\nbusiness O\ndivision O\nsaid O\non O\nthe O\nsidelines O\nof O\nan O\nAOL B-ORG\nnews O\nconference O\nat O\nthe O\nCeBIT B-MISC\nHome O\nconsumer O\nelectronics O\nfair O\nin O\nHanover O\n. O\n\nJan B-PER\nBuettner I-PER\n, O\nmanaging O\ndirector O\nof O\nAOL B-ORG\nGermany I-ORG\n, O\nsaid O\nAdOn B-ORG\nwas O\nin O\nthe O\nformation O\nphase O\nand O\nwould O\n\" O\nget O\noff O\nthe O\nground O\nnext O\nyear O\n, O\nbringing O\nin O\nadvertising O\nfrom O\naround O\nEurope B-LOC\n. O\n\" O\n\nHe O\nwould O\ngive O\nno O\nforecasts O\non O\nadvertising O\nrevenue O\n. O\n\nAOL B-ORG\nis O\nthe O\nleading O\nglobal O\ncommercial O\nonline O\nservice O\nwith O\nsome O\nsix O\nmillion O\nsubscribers O\nworldwide O\n. O\n\nIt O\nhas O\naround O\n200,000 O\nsubscribers O\nin O\nEurope B-LOC\n, O\nwith O\ntwo O\nthirds O\nof O\nthat O\nnumber O\nin O\nGermany B-LOC\nalone O\n. O\n\nIn O\nEurope B-LOC\n, O\nthe O\nservice O\nis O\navailable O\nin O\nGermany B-LOC\n, O\nFrance B-LOC\nand O\nBritain B-LOC\n. O\n\nIt O\nwill O\nbe O\navailable O\nin O\nAustria B-LOC\nand O\nSwitzerland B-LOC\nlater O\nthis O\nyear O\nand O\nin O\nScandanavia O\nand O\nthe O\nBenelux B-LOC\ncountries O\nnext O\nyear O\n. O\n\n-- O\nWilliam B-PER\nBoston I-PER\n, O\nCeBIT B-MISC\nnewsroom O\n, O\n0172 O\n6736510 O\n\n-DOCSTART- O\n\nAll O\npassengers O\nfreed O\nfrom O\nSudanese B-MISC\nhijack O\nplane O\n. O\n\nSTANSTED B-LOC\n, O\nEngland B-LOC\n1996-08-27 O\n\nAll O\npassengers O\nheld O\nhostage O\naboard O\na O\nhijacked O\nSudanese B-MISC\nAirways O\nplane O\ndiverted O\nto O\nLondon B-LOC\n's O\nStansted B-LOC\nairport O\ncarrying O\n199 O\npassengers O\nand O\ncrew O\nhave O\nbeen O\nfreed O\n, O\nan O\nairport O\nspokeswoman O\nsaid O\non O\nTuesday O\n. O\n\nEyewitnesses O\nsaid O\nsix O\ncrew O\nmembers O\nhad O\nalso O\nbeen O\nallowed O\nto O\nleave O\nthe O\naircraft O\n. O\n\nAirport O\nspokeswoman O\nRona B-PER\nYoung I-PER\nconfirmed O\nthat O\nall O\nthe O\npassengers O\nhad O\nleft O\nthe O\naircraft O\n. O\n\nPolice O\nsaid O\na O\nnumber O\nof O\ncrew O\nmembers O\nhad O\nleft O\nthe O\naircraft O\nand O\nsaid O\ndetails O\nwould O\nbe O\ngiven O\nat O\na O\nnews O\nconference O\nexpected O\nto O\nbe O\nheld O\nin O\nthe O\nnext O\nfew O\nminutes O\nby O\nthe O\nlocal O\npolice O\nchief O\n. O\n\nThe O\npassengers O\nwere O\nreleased O\nin O\nbatches O\nduring O\nthe O\ncourse O\nof O\nthe O\nmorning O\nafter O\nthe O\nAirbus B-MISC\nA310 I-MISC\nlanded O\nat O\nStansted B-LOC\n, O\nhaving O\nbeen O\ndiverted O\nfrom O\nCyprus B-LOC\n. O\n\nThe O\naircraft O\nwas O\nhijacked O\non O\na O\nflight O\nfrom O\nKhartoum B-LOC\nto O\nAmman B-LOC\nby O\nsix O\nor O\nseven O\nmen O\n, O\nwho O\npolice O\nsay O\nmay O\nbe O\nIraqis B-MISC\n. O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+ O\n00--44-171-542-7947 O\n\n-DOCSTART- O\n\nSwiss B-ORG\nBank I-ORG\nCorp I-ORG\nsets O\nwarrants O\non O\nDTB-Bund-Future B-MISC\n. O\n\nLONDON B-LOC\n1996-08-27 O\n\nSwiss B-ORG\nBank I-ORG\nCorp I-ORG\nsays O\nit O\nhas O\nissued O\n60 O\nmillion O\nAmerican-style B-MISC\ncall O\nand O\nput O\nwarrants O\n, O\nin O\nsix O\nequal O\ntranches O\n, O\non O\nthe O\nDTB-Bund-Future B-MISC\nMarch O\n1997 O\n. O\n\nEXERCISE O\nPERIOD O\n02.SEP.96-06.MAR.97 O\nPAYDATE O\n30.AUG.96 O\n\nLISTING O\nFFT O\nDDF O\nMIN O\nEXER O\nLOT O\n100 O\n\nSPOT O\nREFERENCE O\n95.35 O\nPCT O\n\nWARRANTS O\nSTRIKE O\nISS O\nPRICE O\nPREMIUM O\nGEARING O\n\nCALL O\nA O\n96.00 O\nPCT O\n1.16 O\nDEM B-MISC\n1.90 O\nPCT O\n82.20 O\nX O\n\nCALL O\nB O\n97.00 O\nPCT O\n0.75 O\nDEM B-MISC\n2.50 O\nPCT O\n127.10 O\nX O\n\nCALL O\nC O\n98.00 O\nPCT O\n0.47 O\nDEM B-MISC\n3.30 O\nPCT O\n202.90 O\nX O\n\nPUT O\nD O\n94.00 O\nPCT O\n0.94 O\nDEM B-MISC\n2.40 O\nPCT O\n101.40 O\nX O\n\nPUT O\nE O\n95.0 O\nPCT O\n1.33 O\nDEM B-MISC\n1.80 O\nPCT O\n71.70 O\nX O\n\nPUT O\nF O\n96.0 O\nPCT O\n1.84 O\nDEM B-MISC\n1.20 O\nPCT O\n51.80 O\nX O\n\n-- O\nReuter B-ORG\nLondon I-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n7658 O\n\n-DOCSTART- O\n\nDBRS B-ORG\nconfirms O\nPower B-ORG\nCorp I-ORG\n, O\nPower B-ORG\nFinancial O\nratings O\n. O\n\nTORONTO B-LOC\n1996-08-27 O\n\nDominion B-ORG\nBond I-ORG\nRating I-ORG\nService I-ORG\nsaid O\non O\nTuesday O\nit O\nconfirmed O\nthe O\nratings O\non O\nPower B-ORG\nCorp I-ORG\nof I-ORG\nCanada I-ORG\n's O\nsenior O\ndebt O\nand O\npreferred O\nshares O\nat O\nA O\n( O\nhigh O\n) O\nand O\nPfd-2 O\n, O\nrespectively O\n, O\nwith O\nstable O\ntrends O\n. O\n\nDBRS B-ORG\nsaid O\nit O\nalso O\nconfirmed O\nPower B-ORG\nFinancial I-ORG\nCorp I-ORG\n's O\nsenior O\ndebentures O\n, O\ncumulative O\npreferred O\nshares O\nand O\nnon-cumulative O\nfirst O\npreferred O\nshares O\n, O\nseries O\nB O\n, O\nat O\nAA O\n( O\nlow O\n) O\n, O\nPfd-1 O\nand O\nPfd-1 O\n( O\nlow O\n) O\n, O\nall O\nwith O\nstable O\ntrends O\n. O\n\n-DOCSTART- O\n\nTurkey B-LOC\n's O\nKurd B-MISC\nrebels O\nkill O\ntwo O\n, O\ntake O\nthree O\nhostage O\n. O\n\nANKARA B-LOC\n1996-08-27 O\n\nKurdish B-MISC\nguerrillas O\nkilled O\ntwo O\npeople O\nand O\ntook O\nthree O\nhostage O\nafter O\nstopping O\ntwo O\nintercity O\nbuses O\nat O\na O\nroadblock O\nin O\neastern O\nTurkey B-LOC\n, O\nsecurity O\nofficials O\nsaid O\non O\nTuesday O\n. O\n\nThey O\ntold O\nreporters O\na O\ngroup O\nof O\nKurdistan B-ORG\nWorkers I-ORG\nParty I-ORG\n( O\nPKK B-ORG\n) O\nguerrillas O\nstopped O\nthe O\nbuses O\nat O\na O\nroadblock O\non O\nthe O\nroad O\nlinking O\nthe O\neastern O\nprovinces O\nof O\nErzincan B-LOC\nand O\nSivas B-LOC\non O\nMonday O\nnight O\nand O\nforced O\nthe O\npassengers O\nto O\nget O\nout O\n. O\n\nThe O\nrebels O\nkilled O\none O\nof O\nthe O\ndrivers O\nand O\na O\npassenger O\nafter O\nchecking O\nthe O\nidentities O\nof O\nthe O\npassengers O\n, O\nthey O\nsaid O\n. O\n\nThe O\nofficials O\nsaid O\nthe O\nrebels O\nset O\nablaze O\ntwo O\nbuses O\nand O\nreleased O\nall O\nbut O\nthree O\npassengers O\n. O\n\nMore O\nthan O\n20,000 O\npeople O\nhave O\nbeen O\nkilled O\nin O\nthe O\n12-year-old O\nconflict O\nbetween O\nTurkish B-MISC\ntroops O\nand O\nPKK B-ORG\nguerrillas O\nfighting O\nfor O\nautonomy O\nor O\nindependence O\nfrom O\nTurkey B-LOC\n. O\n\n-DOCSTART- O\n\nEgypt B-LOC\nconfiscates O\npaper O\nfor O\n\" O\nmad O\nrulers O\n\" O\narticle O\n. O\n\nCAIRO B-LOC\n1996-08-27 O\n\nEgypt B-LOC\nhas O\nbanned O\nand O\nconfiscated O\n10,000 O\ncopies O\nof O\nthe O\nCyprus-based B-MISC\nArabic B-MISC\nmonthly O\nnewspaper O\nal-Tadamun B-ORG\nbecause O\nof O\nan O\neditorial O\nsuggesting O\nmental O\nhealth O\ntests O\nfor O\nArab B-MISC\nleaders O\n, O\nthe O\neditor-in-chief O\nsaid O\non O\nTuesday O\n. O\n\nMohamed B-PER\nAbu I-PER\nLiwaya I-PER\n, O\nsaid O\nInformation B-ORG\nMinistry I-ORG\ncensors O\nhad O\ntold O\nhim O\nto O\nsend O\nall O\nthe O\ncopies O\nof O\nthe O\nAugust O\nedition O\nback O\nto O\nCyprus B-LOC\nat O\nhis O\nown O\nexpense O\n. O\n\nHe O\ntold O\nReuters B-ORG\nthe O\nreason O\nwas O\nhis O\nown O\nfront-page O\neditorial O\n, O\nentitled O\n\" O\nA O\nChronic O\nMental O\nIllness O\n\" O\nin O\nwhich O\nhe O\nattacks O\ncompliant O\nArab B-MISC\nleaders O\nfor O\nserving O\nU.S. B-LOC\nand O\nIsraeli B-MISC\ninterests O\n. O\n\n\" O\nThe O\nArabs B-MISC\ndemand O\nthat O\nour O\nArab B-MISC\nleaders O\nundergo O\na O\ncompulsory O\nexamination O\nby O\na O\nteam O\nof O\npsychiatrists O\nto O\nsee O\nhow O\nsound O\ntheir O\nmental O\ncapacities O\nare O\n, O\n\" O\nthe O\neditorial O\nsaid O\n. O\n\n\" O\nBecause O\nour O\nleaders O\nhave O\nstarted O\nto O\nbehave O\nwith O\nextreme O\nhostility O\ntowards O\nthe O\ninterests O\nof O\ntheir O\npeoples O\nto O\ncourt O\nthe O\ngoodwill O\nof O\nthe O\nAmericans B-MISC\nand O\nthe O\nZionists B-MISC\n, O\n\" O\nhe O\nadded O\n. O\n\nThe O\ncensorship O\noffice O\ndenied O\nthey O\nhad O\nconfiscated O\nthe O\nnewspapers O\nbut O\ndeclined O\nto O\nsay O\nwhen O\nthey O\ncould O\ngo O\non O\nsale O\n. O\n\n-DOCSTART- O\n\nIPO B-ORG\nFILING O\n- O\nTranskaryotic B-ORG\nTherapies I-ORG\nInc I-ORG\n. O\n\nWASHINGTON B-LOC\n1996-08-27 O\n\nCompany O\nName O\nTranskaryotic B-ORG\nTherapies I-ORG\nInc I-ORG\n\nNasdaq B-MISC\nStock O\nsymbol O\nTKTX O\n\nEstimated O\nprice O\nrange O\n$ O\n13 O\n- O\n$ O\n15 O\n/ O\nshr O\n\nTotal O\nshares O\nto O\nbe O\noffered O\n2.5 O\nmillion O\n\nShrs O\noffered O\nby O\ncompany O\n2.5 O\nmillion O\n\nShrs O\noutstanding O\nafter O\nipo O\n16,668,560 O\n\nLead O\nUnderwriter O\nMorgan B-ORG\nStanley I-ORG\nand I-ORG\nCo I-ORG\nInc I-ORG\n\nUnderwriters O\nover-allotment O\n375,000 O\nshrs O\nShares O\nto O\nbe O\npurchased O\nby O\nHoechst B-ORG\nMarion I-ORG\nRoussel I-ORG\nInc I-ORG\n357,143 O\nBusiness O\n: O\ndeveloped O\ntwo O\nproprietary O\ntechnology O\nplatforms O\n, O\ngene O\nactivation O\nand O\ngene O\ntherapy O\n. O\n\nUse O\nof O\nProceeds O\n: O\nResearch O\n, O\npreclinical O\nand O\nclinical O\nproduct O\ndevelopment O\n, O\nand O\ngeneral O\ncorporate O\npurposes O\n. O\n\nFinancial O\nData O\nin O\n000s O\n: O\n1995 O\n1994 O\n\n- O\nRevenue O\n$ O\n15,400 O\n$ O\n10,000 O\n\n- O\nNet O\nIncome O\n( O\nloss O\n) O\n$ O\n2,074 O\n( O\n$ O\n3,422 O\n) O\n\n-DOCSTART- O\n\nAMTRAK B-ORG\ntrain O\nhits O\ntruck O\n, O\nderails O\nin O\nVermont B-LOC\n. O\n\nMONTPELIER B-LOC\n, O\nVt B-LOC\n. O\n\n1996-08-27 O\n\nAn O\nAmtrak B-ORG\ntrain O\nstruck O\na O\nlogging O\ntruck O\nearly O\non O\nTuesday O\nand O\nderailed O\n, O\nVermont B-LOC\nstate O\npolice O\nsaid O\n. O\n\nA O\nstate O\npolice O\nspokeswoman O\nsaid O\nthere O\nwere O\nreports O\nof O\nminor O\ninjuries O\nas O\na O\nresult O\nof O\nthe O\nderailment O\nnear O\nRoxbury B-LOC\n, O\na O\nsmall O\ntown O\non O\nthe O\nedge O\nof O\nthe O\nNorthfield B-LOC\nMountains I-LOC\nsome O\n15 O\nmiles O\nsouthwest O\nof O\nMontpelier B-LOC\n, O\nthe O\nstate O\ncapital O\n. O\n\nFurther O\ndetails O\nwere O\nnot O\nimmediately O\navailable O\n. O\n\n-DOCSTART- O\n\nWife O\nof O\ngun O\nvictim O\nBrady B-PER\npraises O\nClinton B-PER\n. O\n\nCHICAGO B-LOC\n1996-08-26 O\n\nSarah B-PER\nBrady I-PER\n, O\nwhose O\nRepublican B-MISC\nhusband O\nwas O\nseverely O\ndisabled O\nin O\nan O\nassassination O\nattempt O\non O\nPresident O\nRonald B-PER\nReagan I-PER\n, O\ntook O\ncentre O\nstage O\nat O\nthe O\nDemocratic B-MISC\nNational I-MISC\nconvention I-MISC\non O\nMonday O\nnight O\nto O\npraise O\nPresident O\nBill B-PER\nClinton I-PER\n's O\ngun O\ncontrol O\nefforts O\n. O\n\nWith O\nher O\nhusband O\nJames B-PER\nsitting O\nin O\na O\nwheelchair O\nto O\nthe O\nside O\nof O\nthe O\npodium O\n, O\nMrs. O\nBrady B-PER\ncalled O\nthe O\nhandgun O\ncontrol O\nbill O\nthat O\na O\nDemocratic B-MISC\nCongress B-ORG\npassed O\nand O\nClinton B-PER\nsigned O\nin O\n1994 O\na O\nmajor O\nstep O\nin O\ncontrolling O\nfirearm O\nviolence O\nin O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\nBut O\nshe O\nsaid O\nmore O\nhad O\nto O\nbe O\ndone O\n. O\n\nThe O\nBradys B-PER\nwalked O\non O\nto O\nthe O\nstage O\n, O\nhe O\non O\nher O\narm O\nand O\nwith O\nthe O\naid O\nof O\na O\ncane O\n, O\nto O\na O\nrousing O\nreception O\nfrom O\nthe O\nconvention O\n. O\n\nTheir O\nteenaged O\nson O\nsat O\nin O\na O\nVIP O\nbox O\nwith O\nfirst O\nlady O\nHillary B-PER\nRodham I-PER\nClinton I-PER\nand O\nwatched O\nas O\nhis O\nfather O\nreturned O\nto O\nhis O\nwheelchair O\n. O\n\n\" O\nJim B-PER\n, O\nwe O\nmust O\nhave O\nmade O\na O\nwrong O\nturn O\n. O\n\nThis O\nis O\nn't O\nSan B-LOC\nDiego I-LOC\n( O\nsite O\nof O\nthe O\nRepublican B-MISC\nconvention O\n) O\n, O\n\" O\nMrs. O\nBrady B-PER\njoked O\nto O\nher O\nhusband O\n, O\nwho O\nwas O\nserving O\nas O\nReagan B-PER\n's O\npress O\nsecretary O\nwhen O\nhe O\nwas O\nshot O\n. O\n\n\" O\nSarah B-PER\n, O\nI O\ntold O\nyou O\nthis O\nis O\nthe O\nDemocratic B-MISC\nconvention O\n, O\n\" O\nhe O\nresponded O\nto O\nhis O\nwife O\n, O\nwho O\nbefore O\nthe O\nshooting O\nhad O\nworked O\nfor O\ntwo O\nRepublican B-MISC\ncongressmen O\nand O\nthe O\nRepublican B-MISC\nnational O\nparty O\n. O\n\n\" O\nSince O\nthe O\nBrady B-MISC\nLaw I-MISC\nwent O\ninto O\neffect O\non O\nFebruary O\n28 O\n, O\n1994 O\n( O\nit O\n) O\nhas O\nstopped O\nmore O\nthan O\n100,000 O\nconvicted O\nfelons O\nand O\nother O\nprohibited O\npurchasers O\nfrom O\nbuying O\na O\nhandgun O\n. O\n\nToday O\n, O\nand O\nevery O\nday O\n, O\nthe O\nBrady B-MISC\nLaw I-MISC\nis O\nstopping O\nan O\nestimated O\n85 O\nfelons O\nfrom O\nbuying O\na O\nhandgun O\n, O\n\" O\nMrs. O\nBrady B-PER\nsaid O\n. O\n\nShe O\nadded O\n, O\n\" O\nBut O\nwe O\nneed O\nto O\ndo O\nmore O\n. O\n\nWe O\nshould O\n, O\nas O\nPresident O\nClinton B-PER\nproposed O\ntoday O\n, O\nstop O\npeople O\nconvicted O\nof O\ndomestic O\nviolence O\nfrom O\nbuying O\na O\nhandgun O\n. O\n\nJim B-PER\nand O\nI O\njoin O\nwith O\nyou O\ntonight O\nin O\nsaluting O\nthe O\ngreat O\njob O\nthat O\nPresident O\nClinton B-PER\nhas O\ndone O\nin O\nfighting O\ncrime O\nand O\ngun O\nviolence O\n. O\n\" O\n\n\" O\nHe O\n's O\na O\nhunter O\nand O\na O\nsportsman O\n, O\nbut O\nhe O\nunderstands O\nthe O\ndifference O\nbetween O\na O\nRemington B-MISC\nrifle O\nand O\nan O\nAK47 B-MISC\n. O\n\nAnd O\nhe O\nknows O\nthat O\nyou O\ndo O\nn't O\ngo O\nhunting O\nwith O\nan O\nUzi B-MISC\n. O\n\nMr. O\nPresident O\nyou O\ndeserve O\nour O\nthanks O\n. O\n\" O\n\nJim B-PER\nBrady I-PER\nthen O\ngave O\na O\nbig O\nthumbs O\nto O\nthe O\naudience O\n. O\n\nBrady B-PER\n\nwas O\nshot O\nin O\nthe O\nhead O\nin O\n1981 O\nby O\ngunman O\nJohn B-PER\nHinckley I-PER\n, O\nwho O\ntried O\nto O\nkill O\nReagan B-PER\nin O\na O\nderanged O\nbid O\nto O\nimpress O\nJodie B-PER\nFoster I-PER\n, O\nan O\nactress O\nhe O\nnever O\nmet O\nbut O\nwith O\nwhom O\nhe O\nwas O\nobsessed O\n. O\n\nThe O\nBrady B-PER\nbill O\n, O\ncalling O\nfor O\na O\nwaiting O\nperiod O\nbefore O\nsomeone O\ncould O\nbuy O\na O\ngun O\nso O\na O\nbackground O\ncheck O\ncould O\nbe O\nmade O\n, O\nwas O\nfirst O\nintroduced O\nin O\nCongress B-ORG\nin O\n1987 O\nbut O\nit O\ntook O\nseven O\nyears O\nto O\npass O\nbecause O\nof O\nopposition O\nfrom O\nthe O\nNational B-ORG\nRifle I-ORG\nAssociation I-ORG\ngun O\nlobby O\n. O\n\n-DOCSTART- O\n\nLatest O\nopinion O\npolls O\non O\nGerman B-MISC\npolitical O\nparties O\n. O\n\nBONN B-LOC\n1996-08-27 O\n\nHere O\nare O\nthe O\nlatest O\nopinion O\npolls O\ntracking O\nnational O\nsupport O\nfor O\nGermany B-LOC\n's O\nmain O\npolitical O\nparties O\n: O\n\nAUGUST O\n1996 O\nCDU B-ORG\n/ I-ORG\nCSU I-ORG\nSPD B-ORG\nFDP B-ORG\nGreens B-ORG\nPDS B-ORG\n\nEmnid B-ORG\nAug O\n25 O\n41.0 O\n34.0 O\n7.0 O\n10.0 O\n6.0 O\n\nElect B-ORG\nRes I-ORG\nAug O\n23 O\n41.0 O\n35.0 O\n5.0 O\n11.0 O\n4.0 O\n\nAllensbach B-ORG\nAug O\n21 O\n37.2 O\n32.8 O\n8.0 O\n13.0 O\n5.6 O\n\nEmnid B-ORG\nAug O\n18 O\n41.0 O\n34.0 O\n6.0 O\n10.0 O\n5.0 O\n\nJULY O\n1996 O\nCDU B-ORG\n/ I-ORG\nCSU I-ORG\nSPD B-ORG\nFDP B-ORG\nGreens B-ORG\nPDS B-ORG\n\nEmnid B-ORG\nJuly O\n7 O\n39.0 O\n32.0 O\n7.0 O\n11.0 O\n5.0 O\n\nElect B-ORG\nRes I-ORG\nJuly O\n40.0 O\n33.0 O\n6.0 O\n12.0 O\n4.0 O\n\nJUNE O\n1996 O\nCDU B-ORG\n/ I-ORG\nCSU I-ORG\nSPD B-ORG\nFDP B-ORG\nGreens B-ORG\nPDS B-ORG\n\nEmnid B-ORG\nJune O\n30 O\n39.0 O\n33.0 O\n6.0 O\n12.0 O\n5.0 O\n\nElect B-ORG\nRes I-ORG\nJune O\n21 O\n42.0 O\n33.0 O\n6.0 O\n12.0 O\n4.0 O\n\nAllensbach B-ORG\nJune O\n12 O\n37.4 O\n32.8 O\n7.3 O\n12.3 O\n5.4 O\n\nForsa B-ORG\nJune O\n6 O\n39.0 O\n36.0 O\n6.0 O\n12.0 O\n5.0 O\n\nMAY O\n1996 O\nCDU B-ORG\n/ I-ORG\nCSU I-ORG\nSPD B-ORG\nFDP B-ORG\nGreens B-ORG\nPDS B-ORG\n\nEmnid B-ORG\nMay O\n26 O\n40.0 O\n31.0 O\n6.0 O\n13.0 O\n6.0 O\n\nElect B-ORG\nRes I-ORG\nMay O\n25 O\n43.0 O\n32.0 O\n6.0 O\n12.0 O\n4.0 O\n\nForsa B-ORG\nMay O\n23 O\n38.0 O\n37.0 O\n7.0 O\n11.0 O\n5.0 O\n\nAllensbach B-ORG\nMay O\n15 O\n38.5 O\n32.5 O\n8.1 O\n12.0 O\n4.4 O\n\nAPRIL O\n1996 O\nCDU B-ORG\n/ I-ORG\nCSU I-ORG\nSPD B-ORG\nFDP B-ORG\nGreens B-ORG\nPDS B-ORG\n\nEmnid B-ORG\nApril O\n28 O\n40.0 O\n32.0 O\n5.0 O\n11.0 O\n5.0 O\n\nElect B-ORG\nRes I-ORG\nApril O\n20 O\n43.0 O\n32.0 O\n6.0 O\n12.0 O\n4.0 O\n\nAllensbach B-ORG\nApril O\n17 O\n38.1 O\n32.3 O\n6.5 O\n12.9 O\n6.3 O\n\nOFFICIAL O\nRESULTS O\nOF O\nTHE O\nOCTOBER O\n16 O\n, O\n1994 O\nGENERAL O\nELECTION O\n: O\n\nCDU B-ORG\n/ I-ORG\nCSU I-ORG\nSPD B-ORG\nFDP B-ORG\nGreens B-ORG\nPDS B-ORG\n\n41.5 O\n36.4 O\n6.9 O\n7.3 O\n4.4 O\n\nNOTE O\n: O\nElect B-ORG\nRes I-ORG\n= O\nElectoral B-ORG\nResearch I-ORG\nGroup I-ORG\n( O\nForschungsgruppe B-ORG\nWahlen I-ORG\n) O\n\n-- O\nBonn B-LOC\nnewsroom O\n, O\n+49 O\n228 O\n2609760 O\n\n-DOCSTART- O\n\nMost O\nhostages O\nfreed O\nfrom O\nhijacked O\nSudanese B-MISC\nplane O\n. O\n\nSTANSTED B-LOC\n, O\nEngland B-LOC\n1996-08-27 O\n\nArmed O\nhijackers O\nbelieved O\nto O\nbe O\nIraqis B-MISC\nreleased O\n140 O\npeople O\non O\nTuesday O\nfrom O\na O\nSudan B-ORG\nAirways I-ORG\nplane O\ncarrying O\n199 O\npassengers O\nand O\ncrew O\nthat O\nlanded O\nin O\nLondon B-LOC\nafter O\nbeing O\ndiverted O\non O\na O\nflight O\nfrom O\nKhartoum B-LOC\nto O\nAmman B-LOC\n, O\npolice O\nsaid O\n. O\n\nPolice O\nspokesman O\nRoger B-PER\nGrimwade I-PER\nsaid O\nthe O\nsix O\nor O\nseven O\nhijackers O\nremained O\non O\nboard O\nthe O\naircraft O\n, O\nwhich O\narrived O\nfrom O\nCyprus B-LOC\nat O\n4.30 O\na.m. O\n( O\n0330 O\nGMT B-MISC\n) O\n. O\n\nHe O\nsaid O\nthey O\nhad O\nmade O\nvarious O\nrequests O\nto O\npolice O\nnegotiators O\nbut O\nstepped O\nback O\nfrom O\nearlier O\nsuggestions O\nthat O\nthe O\nhijackers O\nhad O\nasked O\nto O\nspeak O\nto O\na O\nBritish-based B-MISC\nIraqi B-MISC\npolice O\nnamed O\nas O\nMr O\nSadiki B-PER\n. O\n\nThe O\nhijackers O\n, O\nwho O\nhave O\nsaid O\nthey O\nwant O\nto O\nseek O\nasylum O\nin O\nBritain B-LOC\n, O\nare O\nbelieved O\nto O\nbe O\narmed O\nwith O\ngrenades O\nand O\npossibly O\nother O\nexplosives O\n, O\naccording O\nto O\npolice O\n. O\n\nThey O\nearlier O\nthreatened O\nto O\nblow O\nup O\nthe O\naircraft O\n. O\n\nThe O\nAirbus B-MISC\nA310 I-MISC\nwas O\ndiverted O\nfirst O\nto O\nCyprus B-LOC\n, O\nthen O\nto O\nBritain B-LOC\n. O\n\n-DOCSTART- O\n\nBritish B-ORG\nData I-ORG\nin O\nmerger O\ntalks O\nwith O\nMentmore B-ORG\n. O\n\nLONDON B-LOC\n1996-08-27 O\n\nMentmore B-ORG\nAbbey I-ORG\nsaid O\non O\nTuesday O\nthat O\nmerger O\ndiscussions O\nwere O\ntaking O\nplace O\nwith O\nthe O\nboard O\nof O\nBritish B-ORG\nData I-ORG\nManagement I-ORG\n, O\nan O\ninformation O\nresource O\nmanagement O\nand O\narchive O\nstorage O\ncompany O\n. O\n\nBut O\nit O\nnoted O\nin O\na O\nbrief O\nstatement O\n: O\n\" O\nHowever O\n, O\nit O\nis O\ntoo O\nearly O\nto O\nsay O\nat O\nthis O\nstage O\nwhether O\nor O\nnot O\nterms O\ncan O\nbe O\nagreed O\n. O\n\" O\n\nMentmore B-ORG\nAbbey I-ORG\n, O\nthe O\nUK B-LOC\nstationery O\nand O\nhousewares O\nbusiness O\nformerly O\nknown O\nas O\nPlatignum B-ORG\n, O\nsaid O\nit O\nwas O\nmaking O\nthe O\nstatement O\nin O\nresponse O\nto O\nrecent O\nnewspaper O\narticles O\nlinking O\nthe O\ntwo O\ngroups O\n. O\n\nShares O\nin O\nMentmore B-ORG\nAbbey I-ORG\nedged O\ntwo O\npence O\nhigher O\nto O\n81.5 O\npence O\n, O\nvaluing O\nthe O\ngroup O\nat O\njust O\nunder O\n30 O\nmillion O\nstg O\n. O\n\nBritish B-ORG\nData I-ORG\nManagement I-ORG\n's O\nshares O\nslipped O\n0.5 O\npence O\nto O\n179.5p O\n, O\nvaluing O\nthat O\ncompany O\nat O\naround O\n45 O\nmillion O\nstg O\n. O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n4017 O\n\n-DOCSTART- O\n\nHijacked O\nSudan B-LOC\nplane O\nlands O\nat O\na O\nLondon B-LOC\nairport O\n. O\n\nSTANSTED B-LOC\n, O\nEngland B-LOC\n1996-08-27 O\n\nA O\nhijacked O\nSudan B-ORG\nAirways I-ORG\nplane O\ncarrying O\n199 O\npassengers O\nand O\ncrew O\nlanded O\nat O\nStansted B-LOC\nairport O\njust O\noutside O\nLondon B-LOC\nearly O\non O\nTuesday O\nmorning O\nafter O\nflying O\nfrom O\nCyprus B-LOC\n, O\neyewitnesses O\nsaid O\n. O\n\nThe O\nAirbus B-MISC\n310 I-MISC\nFlight B-MISC\n150 I-MISC\n, O\nwhich O\nwas O\nhijacked O\non O\nMonday O\nevening O\non O\nits O\nway O\nfrom O\nKhartoum B-LOC\nto O\nthe O\nJordanian B-MISC\ncapital O\nAmman B-LOC\n, O\nlanded O\nat O\n4.30 O\na.m. O\n( O\n0330 O\nGMT B-MISC\n) O\nafter O\na O\nflight O\nof O\nmore O\nthan O\nfour O\nhours O\n. O\n\nAt O\nleast O\none O\nof O\nthe O\nunidentified O\nhijackers O\nwas O\napparently O\narmed O\nwith O\ngrenades O\nand O\nTNT O\nand O\nthreatened O\nto O\nblow O\nthe O\nplane O\nup O\nin O\nCyprus B-LOC\nunless O\nit O\nwas O\nrefuelled O\nso O\nthey O\ncould O\nfly O\nto O\nBritain B-LOC\nto O\nclaim O\npolitical O\nasylum O\n. O\n\n\" O\nThey O\nwill O\nsurrender O\nthe O\npassengers O\nthere O\nand O\nsurrender O\nthemselves O\n, O\n\" O\npolice O\nspokesman O\nGlafcos B-PER\nXenos I-PER\ntold O\nreporters O\nat O\nCyprus B-LOC\n's O\nLarnaca B-LOC\nairport O\n. O\n\nSecurity O\nwas O\ntight O\nat O\nStansted B-LOC\nairport O\n, O\nwhich O\nis O\nabout O\n30 O\nmiles O\n( O\n50 O\nkm O\n) O\nnortheast O\nof O\nthe O\ncapital O\n. O\n\nStansted B-LOC\nhas O\nbeen O\ndesignated O\nas O\nthe O\npreferred O\noption O\nfor O\nhandling O\nhijackings O\nin O\nsouthern O\nEngland B-LOC\nbecause O\nit O\nis O\nmore O\nremote O\nthan O\nHeathrow B-LOC\nand O\nGatwick B-LOC\n, O\nLondon B-LOC\n's O\ntwo O\nmajor O\nairports O\n, O\nand O\nhandles O\nless O\nair O\ntraffic O\n. O\n\n-DOCSTART- O\n\nHijacked O\nSudan B-LOC\nplane O\nexpected O\nat O\nLondon B-LOC\n's O\nStansted B-LOC\n. O\n\nLONDON B-LOC\n1996-08-27 O\n\nA O\nhijacked O\nSudan B-ORG\nAirways I-ORG\nplane O\nwith O\n199 O\npassengers O\nand O\ncrew O\non O\nboard O\nwas O\nexpected O\nto O\nland O\nat O\nLondon B-LOC\n's O\nStansted B-LOC\nairport O\nlater O\non O\nTuesday O\nmorning O\n, O\na O\npolice O\nspokeswoman O\nsaid O\n. O\n\n\" O\nThat O\nis O\nthe O\nplan O\nat O\nthe O\nmoment O\n. O\n\nThat O\nis O\nwhere O\nthe O\nplane O\nis O\nbeing O\ndirected O\nto O\n, O\n\" O\nRuth B-PER\nCollin I-PER\nof O\nEssex B-LOC\npolice O\n, O\nthe O\nforce O\nresponsible O\nfor O\nStansted B-LOC\n, O\nsaid O\n. O\n\nStansted B-LOC\n, O\nLondon B-LOC\n's O\nthird-busiest O\nairport O\nafter O\nHeathrow B-LOC\nand O\nGatwick B-LOC\n, O\nis O\nlocated O\nabout O\n30 O\nmiles O\n( O\n48 O\nkm O\n) O\nnortheast O\nof O\nthe O\ncapital O\n. O\n\nBritish B-MISC\nofficials O\nsaid O\nthey O\nwould O\nmuch O\nprefer O\nto O\ndeal O\nwith O\na O\nhijacking O\nat O\nStansted B-LOC\nbecause O\nof O\nits O\nrelatively O\nremote O\nlocation O\nand O\nbecause O\nair O\ntraffic O\nwould O\nbe O\nless O\nbadly O\ndisrupted O\nthere O\nthan O\nat O\nHeathrow B-LOC\nor O\nGatwick B-LOC\n. O\n\nThey O\nsaid O\npolice O\nand O\nthe O\nemergency O\nservices O\nwere O\nimplementing O\na O\nwell-rehearsed O\ncontingency O\nplan O\nto O\nhandle O\nthe O\nhijacking O\n. O\n\nThe O\narmed O\nhijackers O\nof O\nthe O\nAirbus B-MISC\n310 I-MISC\nFlight B-MISC\n150 I-MISC\n, O\nwhich O\nis O\nexpected O\nto O\narrive O\nabout O\n4 O\na.m. O\n( O\n0300 O\nGMT B-MISC\n) O\n, O\nhave O\nsaid O\nthey O\nintend O\nto O\nsurrender O\nand O\nseek O\npolitical O\nasylum O\nin O\nBritain B-LOC\n. O\n\nThe O\nplane O\nwas O\nhijacked O\non O\nits O\nway O\nfrom O\nKhartoum B-LOC\nto O\nthe O\nJordanian B-MISC\ncapital O\nAmman B-LOC\non O\nMonday O\nevening O\nand O\nlanded O\nat O\nLarnaca B-LOC\nairport O\nin O\nCyprus B-LOC\nto O\nrefuel O\n. O\n\nThe O\nidentity O\nand O\nnumber O\nof O\nthe O\nhijackers O\nwas O\nnot O\nknown O\n. O\n\nOne O\nof O\nthem O\nnegotiated O\nthrough O\nthe O\npilot O\nin O\nEnglish B-MISC\n. O\n\nThe O\npilot O\nsaid O\nseveral O\nhijackers O\nappeared O\nto O\nbe O\nplaced O\naround O\nthe O\nplane O\n. O\n\n-DOCSTART- O\n\nPainted O\nparrot O\nscam O\nlands O\nAustralian B-MISC\nin O\njail O\n. O\n\nPERTH B-LOC\n, O\nAustralia B-LOC\n1996-08-27 O\n\nA O\nconman O\nwho O\npainted O\ncommon O\nAustralian B-MISC\nparrots O\nwith O\ndye O\nto O\nmake O\nthem O\nlook O\nlike O\nrare O\nbirds O\nworth O\nthousands O\nof O\ndollars O\nwas O\njailed O\nfor O\nfraud O\non O\nTuesday O\n. O\n\nDenham B-PER\nPeiris I-PER\npainted O\nsix O\ngreen O\nparrots O\n, O\nworth O\nabout O\nA$ B-MISC\n100 O\n( O\nUS$ B-MISC\n79 O\n) O\na O\npair O\n, O\nwith O\na O\ncinnamon O\nhair O\ndye O\nand O\ntraded O\nthem O\nas O\nIndian B-MISC\nRingneck I-MISC\nParrots I-MISC\n, O\nvalued O\nat O\nA$ B-MISC\n14,000 O\na O\npair O\n. O\n\nPeiris B-PER\n, O\n32 O\n, O\nof O\nPerth B-LOC\n, O\nwas O\nsentenced O\nin O\nthe O\nWestern B-MISC\nAustralian I-MISC\nDistrict O\nCourt O\nto O\ntwo O\nyears O\nin O\njail O\nfor O\nfraud O\nafter O\ntrading O\nthree O\npairs O\nof O\nimpostor O\nbirds O\nfor O\n21 O\nparrots O\nworth O\na O\ntotal O\nof O\nA$ B-MISC\n28,000 O\n. O\n\n\" O\nEveryone O\nwas O\nfooled O\n, O\n\" O\nsaid O\npet O\nshop O\nowner O\nShane B-PER\nDrew I-PER\n, O\nwho O\nunknowingly O\ntraded O\nthe O\ndisguised O\nbirds O\n. O\n\n\" O\nI O\n'd O\nalready O\nhad O\nthree O\nlocal O\nbreeders O\nhave O\na O\nlook O\nat O\nthem O\nand O\nsent O\nphotos O\nand O\nvideos O\nof O\nthe O\nbirds O\nto O\nthe O\neastern O\nstates O\nfor O\nauthentication O\n-- O\nthey O\nsaid O\nthey O\n're O\nnice O\nbirds O\n, O\n\" O\nDrew B-PER\ntold O\nreporters O\noutside O\ncourt O\n. O\n\n\" O\nAfter O\nI O\nwas O\ntold O\nthey O\nwere O\ndyed O\n, O\nI O\nchecked O\nthem O\nover O\nagain O\n. O\n\nIt O\nwas O\na O\nperfect O\npaint O\njob O\nexcept O\nfor O\none O\nfeather O\nunder O\na O\nwing O\nof O\none O\nbird O\nthat O\nwas O\nonly O\nhalf O\ndyed O\n, O\n\" O\nDrew B-PER\nsaid O\n. O\n\nDrew B-PER\nsaid O\nPeiris B-PER\n, O\na O\nbird O\nenthusiast O\n, O\nwould O\nhave O\nsucceeded O\nwith O\nthe O\nfraud O\nif O\nhe O\nhad O\nnot O\ntried O\nto O\ntrade O\na O\nfourth O\npair O\nof O\nbogus O\nbirds O\nafter O\nan O\nassociate O\nhad O\ntold O\npolice O\nof O\nthe O\nscam O\n. O\n\nIf O\nnot O\nfor O\nthe O\ninformant O\n, O\nthe O\npainted O\nparrots O\n' O\ntrue O\ncolours O\nwould O\nnot O\nhave O\nbeen O\nknown O\nfor O\nsix O\nmonths O\n, O\nhe O\nsaid O\n. O\n\n\" O\nThey O\nmoult O\nin O\nthe O\nsummer O\n, O\nso O\nfive O\nor O\nsix O\nmonths O\ndown O\nthe O\ntrack O\n, O\nI O\nwould O\nhave O\nlooked O\nlike O\nthe O\nguilty O\nparty O\n, O\n\" O\nDrew B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nNZ B-LOC\nmotorist O\n's O\narrest O\nbrings O\nfree O\nflight O\nto O\nTonga B-LOC\n. O\n\nWELLINGTON B-LOC\n1996-08-27 O\n\nA O\nNew B-LOC\nZealand I-LOC\nmotorist O\ngot O\nan O\nunexpected O\nfree O\nflight O\nto O\nTonga B-LOC\non O\nTuesday O\nafter O\nbeing O\ncaught O\ndrinking O\nand O\ndriving O\n. O\n\nThe O\nman O\ndrew O\nattention O\nto O\nhimself O\nin O\nthe O\nNorth B-PER\nIsland I-PER\ntown O\nof O\nTauranga B-LOC\nwhile O\ntrying O\nto O\nreverse O\nhis O\ncar O\nout O\nof O\na O\npothole O\non O\nSaturday O\nnight O\n. O\n\nHe O\nspun O\nthe O\nwheels O\nso O\nmuch O\nthat O\nthe O\ntyres O\ncaught O\nalight O\nand O\nsmoke O\nbegan O\npouring O\nfrom O\nunder O\nthe O\nbonnet O\n, O\nthe O\nNew B-ORG\nZealand I-ORG\nPress I-ORG\nAssociation I-ORG\nreported O\n. O\n\nPolice O\narrested O\nthe O\nman O\nand O\ncharged O\nhim O\nwith O\ndrink-driving O\n, O\nbut O\nthen O\niscovered O\nhe O\nwas O\nwanted O\nby O\nthe O\nImmigration B-ORG\nService I-ORG\nas O\nan O\noverstayer O\n. O\n\nThe O\nman O\nwas O\ndue O\nto O\ncatch O\na O\nflight O\nto O\nNuku'alofa B-LOC\nin O\nTonga B-LOC\nlater O\non O\nTuesday O\n. O\n\n-DOCSTART- O\n\nIndonesia B-LOC\n's O\nSBPUs O\nauction O\nresults O\n. O\n\nJAKARTA B-LOC\n1996-08-27 O\n\nThe O\nfollowing O\nis O\nthe O\nresult O\nof O\ncentral O\nbank O\nsecurities O\n( O\nSBPUs O\n) O\nauction O\non O\nTuesday O\nat O\n0800 O\nGMT B-MISC\n: O\n\nSBPUs O\nseven-day O\n14-day O\n\nCut-off-rate O\n( O\npercent O\n) O\n15.75 O\n16.00 O\n\nTotal O\n( O\nin O\nbillion O\nrupiah O\n) O\n38.43 O\n218.50 O\n\n-- O\nJakarta B-LOC\nnewsroom O\n+6221 O\n384-6364 O\n\n-DOCSTART- O\n\nSeoul B-LOC\nembassies O\nwarned O\nof O\nterrorist O\nattacks O\n. O\n\nSEOUL B-LOC\n1996-08-27 O\n\nSouth B-LOC\nKorea I-LOC\nhas O\ntold O\nits O\noverseas O\nmissions O\nto O\nstep O\nup O\nsecurity O\nsince O\nits O\nembassy O\nin O\nthe O\nformer O\nYugoslavia B-LOC\nreceived O\na O\nthreat O\nover O\nSeoul B-LOC\n's O\ncrackdown O\non O\nradical O\nstudents O\n, O\nthe O\nforeign O\nministry O\nsaid O\non O\nTuesday O\n. O\n\nA O\nletter O\nto O\nthe O\nBelgrade B-LOC\nembassy O\non O\nMonday O\nunder O\nthe O\nname O\nof O\nthe O\nMacedonian B-ORG\nCommunist I-ORG\nParty I-ORG\ndemanded O\nSouth B-LOC\nKorea I-LOC\nrelease O\ndetained O\nstudent O\nleaders O\n, O\na O\nministry O\nspokesman O\nsaid O\n. O\n\n\" O\nThe O\nletter O\nsaid O\nthe O\nparty O\nwould O\nassault O\nthe O\nembassy O\n, O\nother O\nSouth B-MISC\nKorean-related I-MISC\nfacilities O\nand O\nKorean B-MISC\nnationals O\nunless O\nour O\nauthorities O\nreleased O\narrested O\nstudents O\n, O\n\" O\nhe O\nsaid O\n. O\n\nNearly O\n400 O\nmembers O\nof O\nan O\noutlawed O\nstudent O\ngroup O\nwere O\narrested O\nafter O\nviolent O\nprotests O\ndemanding O\nreunification O\nwith O\ncommunist O\nNorth B-LOC\nKorea I-LOC\nwere O\ncrushed O\nby O\nriot O\npolice O\nat O\na O\nSeoul B-LOC\nuniversity O\nthis O\nmonth O\n. O\n\nAuthorities O\nbranded O\nthe O\nviolence O\n, O\nin O\nwhich O\na O\npolice O\nofficer O\nwas O\nkilled O\n, O\nas O\nan O\nact O\nof O\nterror O\n. O\n\n\" O\nThe O\nministry O\nhas O\nordered O\nthe O\nembassy O\nto O\ntake O\nurgent O\nsecurity O\nmeasures O\nagainst O\npossible O\nterrorist O\nattacks O\n, O\n\" O\nthe O\nofficial O\nsaid O\n, O\nasking O\nnot O\nto O\nbe O\nnamed O\n. O\n\nIt O\nhad O\ncalled O\nfor O\nsimilar O\nprecautions O\nat O\nother O\noverseas O\nmissions O\n, O\nincluding O\nthose O\nin O\nCanada B-LOC\nand O\nBangladesh B-LOC\nwhere O\nleftist O\ngroups O\nhave O\nstaged O\nprotests O\nover O\nthe O\ncrackdown O\n. O\n\n-DOCSTART- O\n\nNuclear O\npact O\nwill O\nbe O\na O\nstep O\nto O\ndisarmament-China B-MISC\n. O\n\nBEIJING B-LOC\n1996-08-27 O\n\nChina B-LOC\non O\nTuesday O\nreaffirmed O\nits O\nsupport O\nfor O\na O\nglobal O\nnuclear O\ntest O\nban O\ntreaty O\nblocked O\nby O\nIndia B-LOC\nlast O\nweek O\n, O\nsaying O\nthe O\npact O\nwould O\nbe O\nan O\nimportant O\nstep O\nin O\nachieving O\ntotal O\nnuclear O\ndisarmament O\n. O\n\n\" O\nAlthough O\nthe O\nfinal O\ndraft O\nof O\nthe O\ntreaty O\nprobably O\ndid O\nn't O\ntotally O\nsatisfy O\nany O\ncountry O\n, O\nit O\nwas O\nin O\ngeneral O\nbalanced O\n, O\n\" O\nthe O\nofficial O\nPeople B-ORG\n's I-ORG\nDaily I-ORG\nnewspaper O\nsaid O\nin O\na O\ncommentary O\n. O\n\nIndia B-LOC\nblocked O\nthe O\nComprehensive B-MISC\nTest I-MISC\nBan I-MISC\nTreaty I-MISC\n( O\nCTBT B-MISC\n) O\nat O\nthe O\nConference B-MISC\non I-MISC\nDisarmament I-MISC\nin O\nGeneva B-LOC\n, O\nsaying O\nthe O\npact O\ndid O\nnot O\ncontain O\na O\nclause O\ncommitting O\nthe O\nfive O\ndeclared O\nnuclear O\npowers O\nto O\na O\ntimetable O\nfor O\nnuclear O\ndisarmament O\n. O\n\nNew B-LOC\nDelhi I-LOC\n's O\nstance O\n, O\nwhich O\nwas O\nseen O\nas O\neffectively O\nthwarting O\n2-1/2 O\nyears O\nof O\nnegotiations O\nat O\nthe O\nConference B-MISC\non I-MISC\nDisarmament I-MISC\n, O\ndrew O\nwidespread O\nbut O\ngenerally O\nmuted O\nforeign O\ncriticism O\n. O\n\nIndia B-LOC\nhas O\nalso O\npledged O\nto O\noppose O\nany O\nforwarding O\nof O\nthe O\ndraft O\ntreaty O\nto O\nthe O\nUnited B-ORG\nNations I-ORG\nGeneral I-ORG\nAssembly I-ORG\n. O\n\nChina B-LOC\nsaid O\nmany O\ncountries O\nhad O\ncompromised O\nto O\ncomplete O\nthe O\ntreaty O\nand O\nthat O\nthe O\nissue O\nof O\na O\ndisarmament O\nschedule O\ncould O\nbe O\ndiscussed O\nin O\nfuture O\nnegotiations O\n. O\n\n\" O\nThe O\ncompletion O\nof O\nthe O\ntest O\nban O\ntreaty O\nwould O\nbe O\nan O\nimportant O\nand O\npractical O\nstep O\nin O\nthe O\ngradual O\nprocess O\nof O\nachieving O\ntotal O\nnuclear O\ndisarmament O\n, O\n\" O\nit O\nsaid O\n. O\n\nChina B-LOC\nhas O\npledged O\nsupport O\nfor O\nthe O\npact O\nsince O\nreaching O\na O\ndeal O\nwith O\nthe O\nUnited B-LOC\nStates I-LOC\nthat O\nmade O\ninternational O\ninspections O\nof O\nnuclear O\nsites O\nmore O\ndifficult O\nthan O\nin O\nearlier O\ndrafts O\nof O\nthe O\naccord O\n. O\n\nThe O\nnewspaper O\nsaid O\nChina B-LOC\nadvocated O\nthe O\ncomplete O\nban O\nand O\ndestruction O\nof O\nnuclear O\nweapons O\nbut O\nthat O\nthere O\nwas O\nlittle O\nhope O\nother O\nnuclear O\npowers O\nwould O\nsoon O\nadopt O\nthe O\nsame O\nstance O\n. O\n\n\" O\nSome O\nnuclear O\npowers O\nstubbornly O\nuphold O\npolicies O\nof O\nnuclear O\ndeterrence O\nbased O\non O\nfirst O\nuse O\nof O\nnuclear O\nweapons O\n, O\n\" O\nit O\nsaid O\n. O\n\nChina B-LOC\nheld O\non O\nJuly O\n29 O\nwhat O\nit O\nsaid O\nwould O\nbe O\nits O\nlast O\nnuclear O\ntest O\nbefore O\na O\nself-imposed O\nmoratorium O\nthat O\ntook O\neffect O\nthe O\nfollowing O\nday O\n. O\n\nChina B-LOC\nwas O\nthe O\nlast O\ndeclared O\nnuclear O\npower O\nto O\nannounce O\na O\nhalt O\nto O\ntesting O\n. O\n\n-DOCSTART- O\n\nJapan B-LOC\ndeclares O\nfood O\npoisoning O\nthreat O\nreceding O\n. O\n\nTOKYO B-LOC\n1996-08-27 O\n\nThe O\ngovernment O\nsaid O\non O\nTuesday O\nthat O\nthe O\nthreat O\nfrom O\na O\nmysterious O\nkiller O\ngerm O\n, O\nwhile O\nstill O\nrequiring O\nvigilance O\n, O\nappears O\nto O\nbe O\nreceding O\nin O\nthe O\nwestern O\nJapan B-LOC\ncity O\nof O\nSakai B-LOC\n, O\nwhere O\nthe O\nepidemic O\nhit O\nthe O\nhardest O\n. O\n\nThe O\nfood O\npoisoning O\nepidemic O\ncaused O\nby O\nthe O\nO-157 B-MISC\ncolon O\nbacillus O\nin O\nSakai B-LOC\nappears O\nto O\nbe O\n\" O\nsettling O\ndown O\n\" O\n, O\nHealth O\nMinister O\nNaoto B-PER\nKan I-PER\nwas O\nquoted O\nby O\na O\ngovernment O\nspokesman O\nas O\ntelling O\nthe O\ncabinet O\n. O\n\nThe O\nO-157 B-MISC\ncolon O\nbacillus O\nhas O\nbeen O\nfound O\nresponsible O\nfor O\na O\nwidespread O\nfood O\npoisoning O\nepidemic O\nthat O\nhas O\nkilled O\n11 O\npeople O\nand O\nmade O\nover O\n9,500 O\nill O\nthis O\nyear O\n. O\n\nSakai B-LOC\n, O\nnear O\nthe O\nregional O\ncommercial O\ncentre O\nof O\nOsaka B-LOC\n, O\nhas O\nbeen O\nhit O\nhardest O\nby O\nthe O\ndeadly O\nbacteria O\n, O\nwith O\nnearly O\n6,500 O\n, O\nmostly O\nschoolchildren O\n, O\naffected O\nby O\nthe O\ndisease O\n. O\n\nTwo O\nchildren O\nin O\nSakai B-LOC\nhave O\ndied O\nfrom O\ncomplications O\nassociated O\nwith O\nthe O\nbacteria O\n. O\n\nKan B-PER\ntold O\na O\ncabinet O\nmeeting O\non O\nTuesday O\nthat O\nno O\nnew O\nvictims O\nhave O\nbeen O\nreported O\nsince O\nAugust O\n8 O\n, O\nindicating O\nthat O\nthe O\npeak O\nhas O\npassed O\n, O\nat O\nleast O\nfor O\nSakai B-LOC\n. O\n\nSakai B-LOC\nofficials O\nagreed O\nwith O\nthe O\nassessment O\n, O\nbut O\nsaid O\nit O\nwas O\ntoo O\nearly O\nto O\nfeel O\nrelieved O\n. O\n\n\" O\nThere O\nare O\nstill O\npatients O\nhospitalised O\nand O\nproblems O\nwhich O\nmust O\nbe O\ndealt O\nwith O\n, O\n\" O\na O\ncity O\nspokesman O\nsaid O\n, O\nciting O\nthe O\nissue O\nof O\nwhether O\nto O\nallow O\nchildren O\ninfected O\nwith O\nthe O\nbacteria O\nbut O\nnot O\nshowing O\nsymptoms O\nto O\nattend O\nschool O\nfrom O\nSeptember O\n. O\n\nHealth O\nauthorities O\nbelieve O\nschool O\nlunches O\nwere O\nthe O\nsource O\nof O\nthe O\nfood O\npoisoning O\nin O\nSakai B-LOC\n, O\nbut O\nresearchers O\nhave O\nbeen O\nunable O\nto O\npinpoint O\nthe O\nexact O\nsource O\nof O\nthe O\ninfection O\n. O\n\nThe O\noutbreak O\nhas O\nprompted O\nauthorities O\nto O\ntighten O\nsanitary O\nstandards O\nat O\nslaughterhouses O\nand O\nmeatpacking O\nplants O\nand O\nsparked O\ncalls O\nfor O\nan O\noverhaul O\nof O\nthe O\nnation O\n's O\nschool O\nlunch O\nprogramme O\n. O\n\nThe O\nministers O\nagreed O\nat O\nTuesday O\n's O\ncabinet O\nmeeting O\nto O\nstep O\nup O\ninspection O\nmeasures O\nfor O\nschool O\nlunches O\nin O\nSeptember O\nand O\nOctober O\n, O\nwhen O\nschools O\naround O\nthe O\ncountry O\nresume O\n. O\n\nJapan B-LOC\n's O\nAgriculture B-ORG\nMinistry I-ORG\nalso O\nannounced O\nthat O\nit O\nwill O\ncompile O\nhygiene O\nguidelines O\nbased O\non O\nU.S. B-LOC\ngovernment O\nmethods O\nof O\nchecking O\nthe O\nsafety O\nof O\nfarm O\nproduce O\nto O\nprevent O\nanother O\noutbreak O\nof O\nthe O\nepidemic O\n. O\n\nAs O\nof O\nMonday O\n, O\n31 O\nchildren O\nwere O\nstill O\nhospitalised O\nin O\nSakai B-LOC\ncity O\n, O\nof O\nwhom O\nsix O\nwere O\nin O\nserious O\ncondition O\n. O\n\n-DOCSTART- O\n\nJapan B-LOC\naluminium O\nshipments O\nsurge O\n8.9 O\npct O\nin O\nJuly O\n. O\n\nTOKYO B-LOC\n1996-08-27 O\n\nJapanese B-MISC\nshipments O\nof O\naluminium O\nmill O\nproducts O\nin O\nJuly O\nsurged O\n8.9 O\npercent O\nover O\nthe O\nsame O\nmonth O\nlast O\nyear O\nto O\n224,609 O\ntonnes O\n, O\nwhile O\nproduction O\nrose O\n6.4 O\npercent O\nto O\n222,457 O\ntonnes O\n, O\naccording O\nto O\npreliminary O\ndata O\nreleased O\non O\nTuesday O\nby O\nthe O\nJapan B-ORG\nAluminium I-ORG\nFederation I-ORG\n. O\n\nThe O\nsurge O\nreflected O\nstrong O\ndemand O\nfrom O\nthe O\nbeverage O\ncan O\nand O\nhousing O\nconstruction O\nsectors O\n, O\nfederation O\nofficials O\nsaid O\n. O\n\nFigures O\nreleased O\ntwo O\nweeks O\nago O\nfrom O\nJapan B-LOC\n's O\nseven O\nlargest O\nmills O\nalready O\nshowed O\nthat O\nJapan B-LOC\n's O\ncan O\nsheet O\noutput O\nreached O\nits O\nhighest O\nmonthly O\nlevel O\never O\nin O\nJuly O\n, O\nreflecting O\nabove-average O\ntemperatures O\nthat O\nsparked O\na O\njump O\nin O\nbeer O\nconsumption O\n. O\n\nA O\nfederation O\nofficial O\nadded O\nthat O\nthe O\nhalf-year O\nthrough O\nSeptember O\n1996 O\nalso O\nappeared O\nlikely O\nto O\nset O\na O\nnew O\nrecord O\nfor O\ncan O\nproduction O\n, O\ndespite O\ncooler O\ntemperatures O\nin O\nAugust O\n. O\n\nJuly O\ninventories O\nstood O\nat O\n75,632 O\ntonnes O\n, O\ndown O\n2.6 O\npercent O\nfrom O\nthe O\nprior O\nmonth O\n. O\n\nJuly O\nfoil O\noutput O\nwas O\noff O\n0.2 O\npercent O\nyear-on-year O\nat O\n11,525 O\ntonnes O\n, O\nwhile O\nfoil O\nshipments O\nfell O\n0.8 O\npercent O\nto O\n11,244 O\ntonnes O\n. O\n\nJune O\nmill O\noutput O\ndata O\nwere O\nrevised O\nslightly O\ndownward O\nto O\n210,622 O\ntonnes O\nfrom O\nthe O\npreliminary O\n210,683 O\n, O\nwhile O\nshipments O\nwere O\nrevised O\nmarginally O\nupward O\nto O\n213,989 O\ntonnes O\nfrom O\n213,845 O\n. O\n\nFinal O\nfigures O\nfor O\nJune O\npegged O\ncan O\nstock O\nshipments O\nat O\n40,144 O\ntonnes O\n, O\nup O\n2.4 O\npercent O\nyear-on-year O\n. O\n\nShipments O\nto O\nthe O\nauto O\nsector O\nfell O\n5.5 O\npercent O\nto O\n15,286 O\ntonnes O\n, O\nwhile O\nthe O\nconstruction O\nsector O\nrose O\n2.4 O\npercent O\nto O\n79,390 O\ntonnes O\n. O\n\nExports O\ndipped O\n3.7 O\npercent O\nto O\n18,867 O\ntonnes O\n. O\n\n-- O\nTokyo B-ORG\nCommodities I-ORG\nDesk I-ORG\n( O\n81-3 O\n3432 O\n6179 O\n) O\n\n-DOCSTART- O\n\nChina B-LOC\nthanks O\nGabon B-LOC\nfor O\nsupport O\non O\nhuman O\nrights O\n. O\n\nBEIJING B-LOC\n1996-08-27 O\n\nChina B-LOC\nhas O\npublicly O\nthanked O\nGabon B-LOC\nfor O\nits O\nstrong O\nsupport O\nat O\nthe O\nUnited B-ORG\nNations I-ORG\nHuman I-ORG\nRights I-ORG\nCommission I-ORG\n, O\nwhere O\nBeijing B-LOC\nhas O\ncome O\nunder O\nattack O\nfrom O\nWestern B-MISC\nnations O\nfor O\nits O\nhuman O\nrights O\nrecord O\n. O\n\nChina B-LOC\n's O\nPresident O\nJiang B-PER\nZemin I-PER\noffered O\nhis O\ngratitude O\nin O\na O\nmeeting O\non O\nMonday O\nwith O\nvisiting O\nGabon B-LOC\nPresident O\nOmar B-PER\nBongo I-PER\n, O\nthe O\nofficial O\nXinhua B-ORG\nnews O\nagency O\nsaid O\n. O\n\nJiang B-PER\nalso O\nacknowledged O\nthe O\nCentral B-MISC\nAfrican I-MISC\nnation O\n's O\nsupport O\nfor O\nChina B-LOC\n's O\nstance O\non O\nTaiwan B-LOC\n, O\nwhich O\nBeijing B-LOC\nviews O\nas O\na O\nrenegade O\nprovince O\n, O\nwhile O\nBongo B-PER\nwas O\nquoted O\nas O\nthanking O\nChina B-LOC\nfor O\neconomic O\nand O\ntechnological O\naid O\n, O\nthe O\nagency O\nsaid O\nlate O\non O\nMonday O\n. O\n\nIn O\nApril O\n, O\nChina B-LOC\nquashed O\na O\ndraft O\nresolution O\nby O\nthe O\nU.N. B-ORG\nHuman I-ORG\nRights I-ORG\nCommission I-ORG\nexpressing O\nconcern O\nover O\ncontinuing O\nreports O\nof O\nBeijing B-LOC\n's O\nviolations O\nof O\nfundamental O\nfreedoms O\n. O\n\nAfter O\nthe O\ndefeat O\nof O\nthe O\nresolution O\n, O\ndrafted O\nby O\nthe O\nEuropean B-ORG\nUnion I-ORG\nand O\nthe O\nUnited B-LOC\nStates I-LOC\n, O\nChina B-LOC\n's O\nForeign B-ORG\nMinistry I-ORG\nthanked O\n26 O\ncountries O\nfor O\nbacking O\nits O\nmotion O\nfor O\n\" O\nno O\naction O\n\" O\non O\nthe O\ndocument O\n. O\n\nIt O\nwas O\nthe O\nsixth O\nyear O\nin O\na O\nrow O\nthat O\nChina B-LOC\navoided O\ncensure O\nat O\nthe O\nU.N. B-ORG\n's O\nmain O\nhuman O\nrights O\nforum O\n. O\n\nChina B-LOC\nhas O\nbeen O\naccused O\nof O\na O\nwide O\nrange O\nof O\nhuman O\nrights O\nabuses O\n, O\noften O\nin O\nviolation O\nof O\nits O\nown O\nlegal O\ncode O\n, O\nin O\nan O\neffort O\nto O\nsilence O\ndissent O\n. O\n\nA O\nXinhua B-ORG\ncommentary O\nearlier O\nthis O\nyear O\nsaid O\na O\nplot O\nby O\nthe O\nWest B-MISC\nto O\nforce O\nits O\nhuman O\nrights O\nstandards O\nand O\nvalues O\non O\nother O\ncountries O\nwas O\ndoomed O\nto O\nfailure O\n. O\n\n-DOCSTART- O\n\nTaiwan B-LOC\n's O\nCooperative B-ORG\nBank I-ORG\ncuts O\nprime O\nlending O\nrate O\n. O\n\nTAIPEI B-LOC\n1996-08-27 O\n\nCooperative B-ORG\nBank I-ORG\nof I-ORG\nTaiwan I-ORG\n, O\none O\nof O\nthe O\nisland O\n's O\nleading O\nstate-run O\nbanks O\n, O\nsaid O\nit O\nwas O\ncutting O\nits O\nprime O\nlending O\nrate O\nby O\n0.05 O\npercentage O\npoint O\n, O\neffective O\non O\nTuesday O\n. O\n\nThe O\nbank O\nsaid O\nin O\na O\nstatement O\nit O\nwas O\ncutting O\nits O\nprime O\nlending O\nrate O\nto O\n7.35 O\npercent O\nfrom O\n7.40 O\npercent O\n. O\n\nIt O\nalso O\nwould O\ncut O\nits O\nthree-month-to-three-year O\ntime O\ndeposit O\nrates O\nby O\nbetween O\n0.05 O\nand O\n0.10 O\npercentage O\npoints O\n. O\n\nThe O\nmoves O\nmade O\nCooperative B-ORG\nthe O\nfirst O\nmajor O\nbank O\nto O\ncut O\nrates O\nin O\nresponse O\nto O\na O\ncall O\non O\nFriday O\nfrom O\ncentral O\nbank O\ngovernor O\nSheu B-PER\nYuan-dong I-PER\n. O\n\nIn O\nthe O\ncentral O\nbank O\n's O\nlatest O\nbid O\nto O\njumpstart O\nTaiwan B-LOC\n's O\nsluggish O\neconomy O\n, O\nSheu B-PER\nordered O\na O\nreduction O\nof O\nup O\nto O\na O\nhalf-percentage O\npoint O\nin O\nbanks O\n' O\nreserve O\nrequirements O\nand O\ncalled O\non O\ncommercial O\nbanks O\nto O\npass O\non O\nthe O\nsavings O\nin O\nthe O\nform O\nof O\ninterest O\nrate O\nreductions O\n. O\n\n-- O\nTaipei B-ORG\nNewsroom I-ORG\n( O\n5080815 O\n) O\n\n-DOCSTART- O\n\nPalestinians B-MISC\nto O\nstrike O\nover O\nJerusalem B-LOC\ndemolition O\n. O\n\nJERUSALEM B-LOC\n1996-08-27 O\n\nPalestinian B-MISC\nleaders O\nin O\nJerusalem B-LOC\ncalled O\non O\nTuesday O\nfor O\na O\ntwo-hour O\nstrike O\nto O\nprotest O\nwhat O\nthey O\ncalled O\nIsrael B-LOC\n's O\nwar O\non O\nArab B-LOC\nEast I-LOC\nJerusalem I-LOC\nafter O\npolice O\ndemolished O\na O\nbuilding O\nthere O\n. O\n\nIsraeli B-MISC\npolice O\ndemolished O\na O\n10 O\nmetre O\n( O\nyard O\n) O\nby O\n20 O\nmetre O\nstructure O\nin O\nJerusalem B-LOC\n's O\nOld B-LOC\nCity I-LOC\nthey O\nsaid O\nhad O\nbeen O\nbuilt O\nwith O\nfunding O\nfrom O\nthe O\nPalestinian B-ORG\nself-rule I-ORG\nAuthority I-ORG\nfor O\nuse O\nas O\na O\nsocial O\nclub O\n. O\n\nPolice O\nused O\na O\nhuge O\ncrane O\nto O\nlift O\na O\nbulldozer O\nover O\nthe O\nOld B-LOC\nCity I-LOC\n's O\nwalls O\nto O\nreach O\nthe O\nbuilding O\namidst O\nnarrow O\nalleys O\n, O\nwitnesses O\nsaid O\n. O\n\nBystanders O\nat O\nthe O\nscene O\nsaid O\nwork O\nhad O\nbegun O\non O\nthe O\nbuilding O\nin O\n1991 O\nand O\nit O\nhad O\nyet O\nto O\nbe O\ncompleted O\nwhen O\nthe O\nIsraeli B-MISC\npolice O\nbulldozed O\nit O\n. O\n\nThe O\nPalestinian B-ORG\nAuthority I-ORG\nwas O\nset O\nup O\nunder O\nthe O\n1993 O\nPLO-Israel B-MISC\ninterim O\npeace O\ndeal O\n. O\n\n\" O\nThere O\nhas O\nbeen O\na O\ncall O\nfor O\na O\ngeneral O\nstrike O\nbetween O\none O\n( O\n1000 O\nGMT B-MISC\n) O\nand O\nthree O\no'clock O\n, O\n\" O\nPalestinian B-MISC\nlawmaker O\nAhmed B-PER\nHashem I-PER\nZighayer I-PER\ntold O\nReuters B-ORG\n. O\n\n\" O\nThis O\nis O\na O\nwar O\nthat O\nhas O\nbeen O\ndeclared O\non O\nus O\nand O\nwe O\nwant O\nour O\npeople O\nto O\ncome O\nand O\nsee O\nthe O\nsite O\nwhere O\nthey O\ndeclared O\nthe O\nwar O\n. O\n\" O\n\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\n's O\ngovernment O\n, O\nwhich O\ntook O\noffice O\nin O\nJune O\n, O\nhas O\nsaid O\nit O\nwill O\nnot O\nallow O\nthe O\nAuthority B-ORG\n, O\nset O\nup O\nunder O\na O\n1993 O\ninterim O\npeace O\ndeal O\nto O\ncontrol O\nparts O\nof O\nthe O\nGaza B-LOC\nStrip I-LOC\nand O\nWest B-LOC\nBank I-LOC\n, O\nto O\noperate O\nin O\nJerusalem B-LOC\n. O\n\nIsrael B-LOC\n's O\nprevious O\ngovernment O\nheld O\nthe O\nsame O\nposition O\nbut O\nin O\ngeneral O\nturned O\na O\nblind O\neye O\nto O\nPalestinian B-ORG\nAuthority I-ORG\nactivity O\nin O\nthe O\ncity O\n. O\n\nTuesday O\n's O\ndemolition O\ncame O\na O\nday O\nafter O\nPLO B-ORG\nofficials O\nsaid O\nthey O\nhad O\nbowed O\nto O\nNetanyahu B-PER\n's O\ndemand O\nthey O\nclose O\noffices O\nin O\nJerusalem B-LOC\n. O\n\nThey O\nsaid O\ntwo O\nof O\nthe O\nthree O\noffices O\nIsrael B-LOC\nwanted O\nclosed O\nhad O\nbeen O\nshut O\n. O\n\nNetanyahu B-PER\nhas O\nmade O\nclosure O\nof O\nthe O\nthree O\noffices O\na O\ncondition O\nfor O\nresuming O\npeace O\nnegotiations O\nwith O\nthe O\nPalestine B-ORG\nLiberation I-ORG\nOrganisation I-ORG\n( O\nPLO B-ORG\n) O\n. O\n\nIsrael B-LOC\ncaptured O\nArab B-LOC\nEast I-LOC\nJerusalem I-LOC\nin O\nthe O\n1967 O\nMiddle B-LOC\nEast I-LOC\nwar O\nand O\nannexed O\nit O\n. O\n\nIt O\nsays O\nit O\nwill O\nnever O\ncede O\nany O\npart O\nof O\nthe O\ncity O\n. O\n\nPalestinians B-MISC\nwant O\nEast B-LOC\nJerusalem I-LOC\nas O\ncapital O\nof O\na O\nfuture O\nstate O\n. O\n\nThe O\ncity O\nis O\nup O\nfor O\nnegotiation O\nat O\nfinal O\npeace O\ntalks O\nwhich O\nhave O\nyet O\nto O\nresume O\nunder O\nNetanyahu B-PER\n. O\n\n-DOCSTART- O\n\nSEC B-ORG\nadopts O\nrules O\nto O\nimprove O\ninvestor O\naccess O\nto O\nbest O\nstock O\nprices O\n. O\n\nWASHINGTON B-LOC\n1996-08-28 O\n\nThe O\nSecurities B-ORG\nand I-ORG\nExchange I-ORG\nCommission I-ORG\nWednesday O\napproved O\nrules O\ndesigned O\nto O\ngive O\nstock O\nmarket O\ninvestors O\na O\nbetter O\nchance O\nat O\ngetting O\nthe O\nbest O\nprice O\navailable O\nfor O\ntheir O\norders O\n. O\n\nThe O\nso-called O\norder O\nhandling O\nrules O\n, O\nwhich O\nwere O\nproposed O\nlast O\nSeptember O\n, O\nwere O\napproved O\nin O\na O\n4-0 O\nvote O\n. O\n\nThe O\nnew O\nrules O\nwill O\nrequire O\nspecialists O\nat O\nstock O\nexchanges O\nand O\nmarket O\nmakers O\non O\nNasdaq B-MISC\nto O\nallow O\ncustomers O\nto O\nview O\nprice O\nquotes O\nfrom O\nother O\nelectronic O\ntrading O\nsystems O\nthat O\nmay O\nnot O\nbe O\nreadily O\navailable O\nto O\nthem O\n. O\n\nThe O\nrules O\nwill O\nalso O\nrequire O\nthat O\ncustomer O\nlimit O\norders O\nbe O\ndisplayed O\nwith O\nprices O\nbetter O\nthan O\nthose O\navailable O\nin O\nquotes O\npublicly O\navailable O\nat O\nthe O\ntime O\n. O\n\nSpecialists O\nand O\nmarket O\nmakers O\nare O\ncompanies O\nor O\nindividuals O\nrecognised O\nas O\nqualified O\nto O\nmaintain O\nan O\norderly O\nmarket O\nin O\na O\nstock O\n. O\n\nIn O\na O\nlimit O\norder O\n, O\ninvestors O\nspecify O\nthe O\nprice O\nat O\nwhich O\nthey O\nare O\nwilling O\nto O\nbuy O\nor O\nsell O\n, O\nas O\nopposed O\nto O\na O\nmarket O\norder O\nexecuted O\nat O\nprevailing O\nprices O\n. O\n\n\" O\nThese O\nrules O\nare O\nintended O\nto O\nempower O\nall O\ninvestors O\n, O\nby O\nallowing O\ntheir O\norders O\nto O\ncompete O\non O\na O\nlevel O\nplaying O\nfield O\n, O\nand O\nby O\nproviding O\nthe O\ndisclosure O\nthey O\nneed O\nto O\nmake O\ninformed O\ndecisions O\n, O\n\" O\nsaid O\nSEC B-ORG\nChairman O\nArthur B-PER\nLevitt I-PER\n. O\n\nThe O\nSEC B-ORG\n's O\ngoal O\n, O\nhe O\nadded O\n, O\nwas O\nto O\ncreate O\n\" O\none O\nsystem O\nwhere O\none O\nprice O\ncould O\nbe O\navailable O\nto O\neverybody O\n. O\n\" O\n\nThe O\ndirector O\nof O\nthe O\nSEC B-ORG\n's O\ndivision O\nof O\nmarket O\nregulation O\n, O\nRichard B-PER\nLindsey I-PER\n, O\nsaid O\nWall B-LOC\nStreet I-LOC\nfirms O\nwill O\nprobably O\nneed O\nto O\nspend O\nabout O\n$ O\n7 O\nmillion O\nto O\ncarry O\nout O\nthe O\nimprovements O\ncalled O\nfor O\nby O\nthe O\nnew O\nrules O\n. O\n\nIn O\nproposing O\nthe O\nrules O\nlast O\nyear O\n, O\nthe O\nSEC B-ORG\nnoted O\nthat O\nwhile O\ntechnology O\nhas O\nimproved O\n, O\ncommonplace O\npractices O\nstill O\nexisted O\nthat O\nworked O\nagainst O\ninvestors O\n' O\nbest O\ninterests O\n. O\n\nIt O\nnoted O\nthat O\ncustomers O\nwhose O\norders O\nwere O\nnot O\ndisplayed O\nlost O\nthe O\nchance O\nof O\ngetting O\nthe O\nbest O\npossible O\nprice O\navailable O\nin O\nthe O\nmarket O\n. O\n\nIt O\nalso O\ncited O\nthe O\npotential O\nproblem O\nof O\na O\ntwo-tiered O\nmarket O\nin O\nwhich O\nmarket O\nmakers O\nquote O\none O\nprice O\nto O\npublic O\ninvestors O\nwhile O\nquoting O\nbetter O\nprices O\nin O\nprivate O\nsystems O\n, O\nthus O\nrobbing O\ninvestors O\nwithout O\naccess O\nto O\n\" O\nhidden O\n\" O\nquotes O\nthe O\nbenefit O\nof O\nthe O\nbest O\navailable O\nprices O\n. O\n\nEarlier O\nthis O\nmonth O\n, O\nthe O\nSEC B-ORG\nsettled O\ncharges O\nof O\nalleged O\nmalpractices O\non O\nNasdaq B-MISC\nwhen O\nthe O\nparent O\nof O\nthe O\nNasdaq B-MISC\nmarket O\n, O\nthe O\nNational B-ORG\nAssociation I-ORG\nof I-ORG\nSecurities I-ORG\nDealers I-ORG\n, O\nagreed O\nto O\nspend O\n$ O\n100 O\nmillion O\nover O\nfive O\nyears O\nto O\nupgrade O\nits O\noversight O\nof O\nbrokers O\n' O\ntrading O\npractices O\n. O\n\nThe O\nSEC B-ORG\ndropped O\na O\nthird O\nproposal O\nthat O\nwould O\nhave O\nallowed O\ninvestors O\nwith O\nmarket O\norders O\nto O\ntrade O\nat O\na O\nbetter O\nprice O\nif O\nthere O\nwere O\nshifts O\nin O\nprices O\nbefore O\ntheir O\norders O\nwere O\nexecuted O\n. O\n\nThe O\nagency O\nsaid O\nit O\nwould O\nmonitor O\neffects O\nof O\nthe O\ntwo O\nnew O\nrules O\nbefore O\nconsidering O\nthe O\n\" O\nprice O\nimprovement O\n\" O\nproposal O\nagain O\n. O\n\nThe O\nagency O\nalso O\nproposed O\nrule O\nchanges O\nthat O\nwould O\nrequire O\ncontinuous O\n\" O\nbid O\n\" O\nand O\n\" O\nask O\n\" O\nquotations O\nfrom O\nexchange O\nspecialists O\nand O\nmarket O\nmakers O\nwho O\ntrade O\nmore O\nthan O\n1 O\npercent O\nof O\na O\nstock O\nduring O\nany O\nquarter O\non O\nNasdaq B-MISC\n. O\n\nThe O\nSEC B-ORG\n's O\nlimit O\norder O\ndisplay O\nrule O\nwill O\nmean O\na O\nmajor O\nchange O\nfor O\nNasdaq B-MISC\n, O\nwhere O\nsuch O\norders O\nhave O\nnever O\nbeen O\ndisplayed O\n. O\n\nThe O\npresident O\nof O\nthe O\nNasdaq B-MISC\n, O\nAlfred B-PER\nBerkeley I-PER\n, O\nwas O\nto O\nhold O\na O\nnews O\nconference O\nWednesday O\nafternoon O\nto O\nelaborate O\non O\nthe O\nnew O\nrules O\n' O\neffects O\non O\nthe O\nmarket O\n, O\nthe O\nsecond O\nlargest O\nin O\nthe O\nworld O\n. O\n\n-DOCSTART- O\n\nITALIAN B-MISC\nCABINET O\nAPPROVES O\nTELEVISION O\nDECREE O\n. O\n\nROME B-LOC\n1996-08-28 O\n\nThe O\nItalian B-MISC\ncabinet O\non O\nWednesday O\ngranted O\na O\nreprieve O\nfor O\nmedia O\nmogul O\nSilvio B-PER\nBerlusconi I-PER\n's O\nMediaset B-ORG\ntelevision O\nempire O\nwith O\na O\ndecree O\nextending O\nthe O\ncurrent O\nlegal O\nframework O\nfor O\ntelevision O\nstations O\nuntil O\nJanuary O\n31 O\n, O\n1997 O\n. O\n\nThe O\ndecree O\nplugs O\na O\nlegal O\nvoid O\nin O\nwhich O\nmagistrates O\ncould O\nhave O\nforced O\nthe O\nformer O\nprime O\nminister O\nto O\ntake O\none O\nof O\nthe O\nthree O\nstations O\nhe O\ncontrols O\noff O\nthe O\nair O\nbecause O\nof O\na O\ncourt O\nruling O\nthat O\nno O\nsingle O\nproprietor O\nshould O\nbe O\nallowed O\nto O\nkeep O\nthree O\nchannels O\n. O\n\n-DOCSTART- O\n\nPassengers O\ninjured O\nin O\ntrain O\ncollision O\nin O\nLinz B-LOC\n. O\n\nLINZ B-LOC\n, O\nAustria B-LOC\n1996-08-28 O\n\nA O\npassenger O\ntrain O\ncollided O\nwith O\na O\nlocomotive O\nat O\na O\nmain O\nrailway O\nstation O\nin O\nLinz B-LOC\non O\nWednesday O\nand O\npolice O\nsaid O\naround O\n10 O\npeople O\nwere O\ninjured O\n. O\n\nAustrian B-MISC\ntelevision O\nreported O\nearlier O\nthat O\nmore O\nthan O\n20 O\nhad O\nbeen O\nhurt O\nin O\nthe O\naccident O\nat O\nthe O\nstation O\nin O\nLinz B-LOC\n, O\n300 O\nkm O\n( O\n180 O\nmiles O\n) O\nwest O\nof O\nVienna B-LOC\n. O\n\n\" O\nOne O\nlocomotive O\nwas O\nstationary O\nand O\nthe O\npassenger O\ntrain O\ncollided O\ninto O\nthe O\nback O\nof O\nit O\n, O\n\" O\na O\npolice O\nspokesman O\nin O\nLinz B-LOC\ntold O\nReuters B-ORG\nby O\ntelephone O\n. O\n\nThe O\nexpress O\npassenger O\ntrain O\ntravelling O\nfrom O\nSteyr B-LOC\n, O\nsoutheast O\nof O\nLinz B-LOC\n, O\nwith O\naround O\n80 O\npeople O\non O\nboard O\n, O\nhit O\nthe O\nback O\nof O\na O\nservice O\nlocomotive O\nused O\nto O\nshunt O\nwagons O\ninto O\nsidings O\n. O\n\nThe O\npolice O\nspokesman O\nsaid O\nhe O\nwas O\nnot O\nsure O\nwhether O\nany O\nmore O\npassengers O\nwere O\nstill O\ntrapped O\nin O\nthe O\nwreckage O\n. O\n\nDoctors O\nand O\nmedical O\nstaff O\nfrom O\na O\nhospital O\nacross O\nthe O\nroad O\nfrom O\nthe O\nstation O\nwere O\nat O\nthe O\nscene O\nof O\nthe O\naccident O\nwithin O\nminutes O\nand O\nwere O\nable O\nto O\ntreat O\nthe O\ninjured O\nquickly O\n, O\nhe O\nadded O\n. O\n\nGreater O\ndamage O\nwas O\naverted O\nas O\nthe O\ndriver O\nof O\nthe O\npassenger O\ntrain O\nhad O\ntime O\nto O\napply O\nhis O\nemergency O\nbrakes O\nbefore O\nthe O\ncollision O\noccurred O\n, O\na O\nstate O\nrailways O\nspokesman O\ntold O\nAustrian B-MISC\nnews O\nagency O\nAPA B-ORG\n. O\n\n-DOCSTART- O\n\nSaskatchewan B-ORG\nWheat I-ORG\nPool I-ORG\neyes O\nhog O\nmarket O\n. O\n\nWINNIPEG B-LOC\n1996-08-28 O\n\nCanada B-LOC\n's O\nlargest O\ngrain O\nhandling O\nfirm O\nsaid O\nWednesday O\nit O\nexpects O\nto O\nforge O\na O\npartnership O\nwith O\nhog O\nfarmers O\nby O\n1997 O\nwith O\na O\nview O\nto O\nexpanding O\nthe O\ncompany O\n's O\nscope O\ninto O\npork O\nproduction O\n. O\n\n\" O\nSaskatchewan B-LOC\nis O\nwell O\npositioned O\nto O\ntake O\nadvantage O\nof O\ngrowing O\nworld O\nmarkets O\nfor O\npork O\n, O\n\" O\nSaskatchewan B-ORG\nWheat I-ORG\nPool I-ORG\nchief O\nexecutive O\nDon B-PER\nLoewen I-PER\nsaid O\nin O\na O\ncompany O\nstatement O\n. O\n\nSWP B-ORG\nsaid O\nit O\nwas O\nanalyzing O\npotential O\npartnerships O\nwith O\nhog O\nfarmers O\nand O\nexpected O\nthe O\nfirst O\ndeal O\nto O\nbe O\nin O\nplace O\nin O\n1997 O\n. O\n\nThe O\nend O\nof O\nCanada B-LOC\n's O\nrail O\nfreight O\nsubsidy O\nlast O\nyear O\ncaused O\na O\nshift O\nin O\nfeed O\ngrain O\nproduction O\nto O\nthe O\neastern O\nPrairie O\n. O\n\nAnalysts O\nsaid O\nlivestock O\nproduction O\nwould O\nlikely O\nshift O\nto O\nthe O\neastern O\nPrairie O\nrather O\nthan O\nfeed O\ngrains O\nbeing O\nshipped O\nto O\nthe O\nwestern O\nPrairie O\n. O\n\nSWP B-ORG\nsaid O\nit O\nmay O\ndevelop O\npork O\nproduction O\nsystems O\nthat O\nprovide O\nfarmers O\nwith O\nlarge O\nintegrated O\nunits O\n, O\nand O\nit O\nmay O\nconsider O\ncontracting O\nprograms O\nbetween O\nproducers O\nand O\npackers O\nwhich O\nwould O\noperate O\nwithin O\nthe O\nexisting O\nhog O\nmarket O\nframework O\n. O\n\nSaskatchewan B-ORG\nPork I-ORG\nInternational I-ORG\nMarketing I-ORG\nGroup I-ORG\nhas O\nan O\nexport O\nmonopoly O\nbut O\nsome O\nSaskatchewan B-LOC\nfarmers O\nearlier O\nthis O\nmonth O\ncalled O\nfor O\nan O\nopen O\nmarket O\nin O\nhogs O\n. O\n\n-- O\nGilbert B-PER\nLe I-PER\nGras I-PER\n204 O\n947 O\n3548 O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nROVERETO B-MISC\nINTERNATIONAL I-MISC\nMEETING O\nRESULTS O\n. O\n\nROVERETO B-LOC\n, O\nItaly B-LOC\n1996-08-28 O\n\nLeading O\nresults O\nfrom O\nan O\n\ninternational O\nathletics O\nmeeting O\non O\nWednesday O\n: O\n\nWomen O\n's O\nlong O\njump O\n: O\n\n1. O\nLudmila B-PER\nNinova I-PER\n( O\nAustria B-LOC\n) O\n6.72 O\nmetres O\n\n2. O\nHeike B-PER\nDrechsler I-PER\n( O\nGermany B-LOC\n) O\n6.65 O\n\n3. O\nFiona B-PER\nMay I-PER\n( O\nItaly B-LOC\n) O\n6.64 O\n\nMen O\n's O\n110 O\nmetres O\nhurdles O\n: O\n\n1. O\nEmilio B-PER\nValle I-PER\n( O\nCuba B-LOC\n) O\n13.42 O\nseconds O\n\n2. O\nSteve B-PER\nBrown I-PER\n( O\nU.S. B-LOC\n) O\n13.45 O\n\n3. O\nAndrea B-PER\nGiaconi I-PER\n( O\nItaly B-LOC\n) O\n13.80 O\n\nWomen O\n's O\n100 O\nmetres O\n: O\n\n1. O\nChandra B-PER\nSturrup I-PER\n( O\nBahamas B-LOC\n) O\n11.34 O\nseconds O\n\n2. O\nNatalya B-PER\nVoronova I-PER\n( O\nRussia B-LOC\n) O\n11.53 O\n\n3. O\nGabi B-PER\nRokmeier I-PER\n( O\nGermany B-LOC\n) O\n11.61 O\n\nMen O\n's O\njavelin O\n: O\n\n1. O\nSergey B-PER\nMakarov I-PER\n( O\nRussia B-LOC\n) O\n85.26 O\nmetres O\n\n2. O\nTom B-PER\nPukstys I-PER\n( O\nU.S. B-LOC\n) O\n84.20 O\n\n3. O\nPeter B-PER\nBlank I-PER\n( O\nGermany B-LOC\n) O\n81.64 O\n\nMen O\n's O\n100 O\nmetres O\n: O\n\n1. O\nOsmond B-PER\nEzinwa I-PER\n( O\nNigeria B-LOC\n) O\n10.13 O\nseconds O\n\n2. O\nDavidson B-PER\nEzinwa I-PER\n( O\nNigeria B-LOC\n) O\n10.18 O\n\n3. O\nStefano B-PER\nTilli I-PER\n( O\nItaly B-LOC\n) O\n10.43 O\n\nMen O\n's O\n400 O\nmetres O\n: O\n\n1. O\nDavis B-PER\nKamoga I-PER\n( O\nUganda B-LOC\n) O\n45.15 O\nseconds O\n\n2. O\nMarco B-PER\nVaccari I-PER\n( O\nItaly B-LOC\n) O\n46.16 O\n\n3. O\nKennedy B-PER\nOchieng I-PER\n( O\nKenya B-LOC\n) O\n46.21 O\n\nWomen O\n's O\npole O\nvault O\n: O\n\n1. O\nMariacarla B-PER\nBresciani I-PER\n( O\nItaly B-LOC\n) O\n3.85 O\nmetres O\n\n2. O\nAndrea B-PER\nMuller I-PER\n( O\nGermany B-LOC\n) O\n3.75 O\n\n3. O\nNastja B-PER\nRysich I-PER\n( O\ngermany B-LOC\n) O\n3.75 O\n\nWomen O\n's O\n800 O\nmetres O\n: O\n\n1. O\nAna B-PER\nFidelia I-PER\nQuirot I-PER\n( O\nCuba B-LOC\n) O\n1 O\nminute O\n58.98 O\nseconds O\n\n2. O\nLetitia B-PER\nVriesde I-PER\n( O\nSurinam B-LOC\n) O\n2:00.39 O\n\n3. O\nInez B-PER\nTurner I-PER\n( O\nJamaica B-LOC\n) O\n2:00.91 O\n\nMen O\n's O\nhigh O\njump O\n: O\n\n1. O\nWolfgang B-PER\nKreissig I-PER\n( O\nGermany B-LOC\n) O\n2.20 O\nmetres O\n\n2. O\nKostantin B-PER\nMatusevitch I-PER\n( O\nIsrael B-LOC\n) O\n2.20 O\n\n3. O\nMichele B-PER\nBuiatti I-PER\n( O\nItaly B-LOC\n) O\n2.15 O\n\nMen O\n's O\n800 O\nmetres O\n: O\n\n1. O\nRobert B-PER\nKibet I-PER\n( O\nKenya B-LOC\n) O\n1:45.24 O\n\n2. O\nVincent B-PER\nMalakwen I-PER\n( O\nKenya B-LOC\n) O\n1:45.62 O\n\n3. O\nPhilip B-PER\nKibitok I-PER\n( O\nKenya B-LOC\n) O\n1:46.09 O\n\nWomen O\n's O\njavelin O\n: O\n\n1. O\nOksana B-PER\nOvchinnikova I-PER\n( O\nRussia B-LOC\n) O\n58.94 O\nmetres O\n\n2. O\nNatalya B-PER\nShikolenko I-PER\n( O\nBelarus B-LOC\n) O\n57.44 O\n\n3. O\nSilke B-PER\nRenk I-PER\n( O\nGermany B-LOC\n) O\n56.70 O\n\nWomen O\n's O\n400 O\nmetres O\nhurdles O\n: O\n\n1. O\nVirna B-PER\nDe I-PER\nAngeli I-PER\n( O\nItaly B-LOC\n) O\n55.66 O\n\n2. O\nNatalya B-PER\nTorshina I-PER\n( O\nKazakhstan B-LOC\n) O\n55.99 O\n\n3. O\nAnna B-PER\nKnoroz I-PER\n( O\nRussia B-LOC\n) O\n57.02 O\n\nMen O\n's O\n400 O\nmetres O\nhurdles O\n: O\n\n1. O\nLauren B-PER\nOttoz I-PER\n( O\nItaly B-LOC\n) O\n49.16 O\n\n2. O\nBrian B-PER\nBronson I-PER\n( O\nU.S. B-LOC\n) O\n49.67 O\n\n3. O\nJohn B-PER\nRidgeon I-PER\n( O\nBritain B-LOC\n) O\n49.83 O\n\nMen O\n's O\n3,000 O\nmetres O\n: O\n\n1. O\nLuke B-PER\nKipkosgei I-PER\n( O\nKenya B-LOC\n) O\n7:46.91 O\n\n2. O\nAlessandro B-PER\nLambruschini I-PER\n( O\nItaly B-LOC\n) O\n7:47.78 O\n\n3. O\nRichard B-PER\nKosgei I-PER\n( O\nKenya B-LOC\n) O\n7:48.38 O\n\n-DOCSTART- O\n\nGOLF B-LOC\n- O\nBRITISH B-MISC\nMASTERS I-MISC\nFIRST O\nROUND O\nSCORES O\n. O\n\nNORTHAMPTON B-LOC\n, O\nEngland B-LOC\n1996-08-28 O\n\nLeading O\ncompleted O\n\nfirst-round O\nscores O\nin O\nthe O\nrain-affected O\nBritish B-MISC\nMasters I-MISC\ngolf O\n\nchampionship O\nat O\nCollingtree B-LOC\nPark I-LOC\non O\nWednesday O\n( O\nBritain B-LOC\nunless O\n\nstated O\n) O\n: O\n\n66 O\nGavin B-PER\nLevenson I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n\n68 O\nColin B-PER\nMontgomerie I-PER\n\n69 O\nJose B-PER\nCoceres I-PER\n( O\nArgentina B-LOC\n) O\n, O\nRaymond B-PER\nRussell I-PER\n, O\nRobert B-PER\nAllenby I-PER\n\n( O\nAustralia B-LOC\n) O\n, O\nDavid B-PER\nGilford I-PER\n, O\nStuart B-PER\nCage I-PER\n, O\nMike B-PER\nClayton I-PER\n\n( O\nAustralia B-LOC\n) O\n, O\nMark B-PER\nRoe I-PER\n, O\nEmanuele B-PER\nCanonica I-PER\n( O\nItaly B-LOC\n) O\n\n70 O\nFrancisco B-PER\nCea I-PER\n( O\nSpain B-LOC\n) O\n, O\nDavid B-PER\nHowell I-PER\n, O\nPeter B-PER\nHedblom I-PER\n\n( O\nSweden B-LOC\n) O\n\n71 O\nSteven B-PER\nBottomley I-PER\n, O\nOve B-PER\nSellberg I-PER\n( O\nSweden B-LOC\n) O\n, O\nJoakim B-PER\nHaeggman I-PER\n\n( O\nSweden B-LOC\n) O\n, O\nStephen B-PER\nAmes I-PER\n( O\nTrinidad B-LOC\nand I-LOC\nTobago I-LOC\n) O\n, O\nKlas B-PER\nEriksson I-PER\n\n( O\nSweden B-LOC\n) O\n, O\nRoger B-PER\nChapman I-PER\n, O\nMark B-PER\nDavis I-PER\n, O\nPierre B-PER\nFulke I-PER\n( O\nSweden B-LOC\n) O\n, O\n\nMartin B-PER\nGates I-PER\n, O\nAnders B-PER\nHaglund I-PER\n( O\nSweden B-LOC\n) O\n\n72 O\nNiclas B-PER\nFasth I-PER\n( O\nSweden B-LOC\n) O\n, O\nMichael B-PER\nJonzon I-PER\n( O\nSweden B-LOC\n) O\n, O\nChistian B-PER\n\nCevaer B-PER\n( O\nFrance B-LOC\n) O\n, O\nThomas B-PER\nBjorn I-PER\n( O\nDenmark B-LOC\n) O\n, O\nTony B-PER\nJohnstone I-PER\n\n( O\nZimbabwe B-LOC\n) O\n, O\nPadraig B-PER\nHarrington I-PER\n( O\nIreland B-LOC\n) O\n, O\nPedro B-PER\nLinhart I-PER\n\n( O\nSpain B-LOC\n) O\n, O\nDavid B-PER\nCarter I-PER\n\n73 O\nRoss B-PER\nMcFarlane I-PER\n, O\nDomingo B-PER\nHospital I-PER\n( O\nSpain B-LOC\n) O\n, O\nSeve B-PER\nBallesteros I-PER\n\n( O\nSpain B-LOC\n) O\n, O\nPaul B-PER\nBroadhurst I-PER\n, O\nGreg B-PER\nTurner I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n, O\nMike B-PER\n\nHarwood B-PER\n( O\nAustralia B-LOC\n) O\n, O\nBrenden B-PER\nPappas I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n, O\nPeter B-PER\n\nTeravainen B-PER\n( O\nU.S. B-LOC\n) O\n, O\nJean B-PER\nVan I-PER\nde I-PER\nVelde I-PER\n( O\nFrance B-LOC\n) O\n, O\nOyvind B-PER\nRojahn I-PER\n\n( O\nNorway B-LOC\n) O\n, O\nStephen B-PER\nMcAllister I-PER\n, O\nNeal B-PER\nBriggs I-PER\n\nNote O\n: O\n77 O\nplayers O\nto O\ncomplete O\ntheir O\nfirst O\nrounds O\non O\nThursday O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nKELLY B-PER\nWINS O\nWORLD O\nTIME O\nTRIAL O\nTITLE O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-28 O\n\nShane B-PER\nKelly I-PER\nof O\nAustralia B-LOC\nretained O\nthe O\nworld O\none-kilometre O\ntime O\ntrial O\ntitle O\nat O\nthe O\nworld O\ntrack O\nchampionships O\non O\nWednesday O\n, O\nwith O\na O\ntrack O\nrecord O\ntime O\nof O\none O\nminute O\n2.777 O\nseconds O\n. O\n\nKelly B-PER\naveraged O\n57.345 O\nkph O\nto O\nbeat O\nSoren B-PER\nLausgberg I-PER\nof O\nGermany B-LOC\nby O\neighteen O\nhundredths O\nof O\na O\nsecond O\n. O\n\nThe O\nbronze O\nmedal O\nwent O\nto O\nanother O\nGerman B-MISC\n, O\nJan B-PER\nVan I-PER\nEijden I-PER\n, O\nin O\n1:04.541 O\n. O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nVAN B-PER\nHEESWIJK I-PER\nWINS O\nSECOND O\nSTAGE O\nOF O\nTOUR B-MISC\nOF I-MISC\nNETHERLANDS I-MISC\n. O\n\nALMERE B-LOC\n, O\nNetherlands B-LOC\n1996-08-28 O\n\nLeading O\nplacings O\nin O\n\nthe O\n195-km O\nsecond O\nstage O\nof O\nthe O\nTour B-MISC\nof I-MISC\nthe I-MISC\nNetherlands I-MISC\nbetween O\n\nHaarlem B-LOC\nand O\nAlmere B-LOC\non O\nWednesday O\n: O\n\n1. O\nMax B-PER\nvan I-PER\nHeeswijk I-PER\n( O\nNetherlands B-LOC\n) O\nMotorola B-ORG\n4 O\nhours O\n39 O\nminutes O\n\nsix O\nseconds O\n. O\n\n2. O\nJohan B-PER\nCapiot I-PER\n( O\nBelgium B-LOC\n) O\nCollstrop B-ORG\n\n3. O\nSven B-PER\nTeutenberg I-PER\n( O\nGermany B-LOC\n) O\nU.S. B-ORG\nPostal I-ORG\n\n4. O\nErik B-PER\nZabel I-PER\n( O\nGermany B-LOC\n) O\nTelekom B-ORG\n\n5. O\nFederico B-PER\nColonna I-PER\n( O\nItaly B-LOC\n) O\nMapei B-ORG\n\n6. O\nJans B-PER\nKoerts I-PER\n( O\nNetherlands B-LOC\n) O\nPalmans B-ORG\n\n7. O\nMichel B-PER\nZanoli I-PER\n( O\nNetherlands B-LOC\n) O\nMX B-ORG\nOnda I-ORG\n\n8 O\n.Giuseppe B-PER\nCitterio I-PER\n( O\nItaly B-LOC\n) O\nAki B-PER\n\n9 O\n.Robbie B-PER\nMcEwen I-PER\n( O\nAustralia B-LOC\n) O\nRabobank B-ORG\n\n10. O\nKaspars B-PER\nOzers I-PER\n( O\nLatvia B-LOC\n) O\nMotorola B-ORG\nall O\nsame O\ntime O\n\nLeading O\noverall O\nplacings O\nafter O\ntwo O\nstages O\n: O\n\n1. O\nColonna B-PER\n8:22:00 O\n\n2. O\nVan B-PER\nHeeswijk I-PER\n1 O\nsecond O\nbehind O\n\n3. O\nMcEwen B-PER\nsame O\ntime O\n\n4. O\nTeutenberg B-PER\n4 O\nseconds O\n\n5. O\nCapiot B-PER\n5 O\n\n6. O\nKoerts B-PER\n7 O\n\n7. O\nOzers B-PER\n8 O\n\n8. O\nGianluca B-PER\nCorini I-PER\n( O\nItaly B-LOC\n) O\nAki B-PER\nsame O\ntime O\n\n9. O\nLance B-PER\nArmstrong I-PER\n( O\nU.S. B-LOC\n) O\nMotorola B-ORG\n9 O\n\n10. O\nGeorge B-PER\nHincapie I-PER\n( O\nU.S. B-LOC\n) O\nMotorola B-ORG\nsame O\ntime O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nVAN B-PER\nHEESWIJK I-PER\nWINS O\nTOUR B-MISC\nOF I-MISC\nNETHERLANDS I-MISC\nSECOND O\nSTAGE O\n. O\n\nALMERE B-LOC\n, O\nNetherlands B-LOC\n1996-08-28 O\n\nLeading O\nresults O\nand O\noverall O\nstandings O\nafter O\nthe O\n195 O\nkilometre O\nsecond O\nstage O\nof O\nthe O\nTour B-MISC\nof I-MISC\nthe I-MISC\nNetherlands I-MISC\nbetween O\nHaarlem B-LOC\nand O\nAlmere B-LOC\non O\nWednesday O\n. O\n\n1. O\nMax B-PER\nvan I-PER\nHeeswijk I-PER\n( O\nNetherlands B-LOC\n) O\nMotorola B-ORG\n4 O\nhours O\n39 O\nminutes O\nsix O\nseconds O\n. O\n\n2. O\nJohan B-PER\nCapiot I-PER\n( O\nBelgium B-LOC\n) O\nCollstrop B-ORG\n\n3. O\nSven B-PER\nTeutenberg I-PER\n( O\nGermany B-LOC\n) O\nU.S. B-ORG\nPostal I-ORG\n\n4. O\nErik B-PER\nZabel I-PER\n( O\nGermany B-LOC\n) O\nTelekom B-ORG\n\n5. O\nFederico B-PER\nColonna I-PER\n( O\nItaly B-LOC\n) O\nMapei B-ORG\n\n6. O\nJans B-PER\nKoerts I-PER\n( O\nNetherlands B-LOC\n) O\nPalmans B-ORG\n\n7. O\nMichel B-PER\nZanoli I-PER\n( O\nNetherlands B-LOC\n) O\nMX B-ORG\nOnda I-ORG\n\n8. O\nGiuseppe B-PER\nCitterio I-PER\n( O\nItaly B-LOC\n) O\nAki B-PER\n\n9. O\nRobbie B-PER\nMcEwen I-PER\n( O\nAustralia B-LOC\n) O\nRabobank B-ORG\n\n10. O\nKaspars B-PER\nOzers I-PER\n( O\nLatvia B-LOC\n) O\nMotorola B-ORG\nall O\nsame O\ntime O\n. O\n\nLeading O\noverall O\nstandings O\nafter O\nsecond O\nstage O\n. O\n\n1. O\nColonna B-PER\n8:22:00 O\n\n2. O\nVan B-PER\nHeeswijk I-PER\n1 O\nsecond O\nbehind O\n\n3. O\nMcEwen B-PER\nsame O\ntime O\n\n4. O\nTeutenberg B-PER\n4 O\nseconds O\n\n5. O\nCapiot B-PER\n5 O\n\n6. O\nKoerts B-PER\n7 O\n\n7. O\nOzers B-PER\n8 O\n\n8. O\nGianluca B-PER\nCorini I-PER\n( O\nItaly B-LOC\n) O\nAki B-PER\nsame O\ntime O\n\n9. O\nLance B-PER\nArmstrong I-PER\n( O\nU.S. B-LOC\n) O\nMotorola B-ORG\n9 O\n\n10. O\nGeorge B-PER\nHincapie I-PER\n( O\nU.S. B-LOC\n) O\nMotorola B-ORG\nsame O\ntime O\n. O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nWORLD O\nCHAMPIONSHIPS O\nRESULTS O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-28 O\n\nResults O\nfrom O\nthe O\n\nworld O\ntrack O\ncycling O\nchampionships O\non O\nWednesday O\n: O\n\nMen O\n's O\nindividual O\npursuit O\n: O\n\nSelected O\nresult O\nfrom O\nfirst O\nround O\n\nChris B-PER\nBoardman I-PER\n( O\nBritain B-LOC\n) O\n4:13.353 O\nseconds O\n( O\nworld O\nrecord O\n) O\ncaught O\n\nJens B-PER\nLehman I-PER\n( O\nGermany B-LOC\n) O\n\nQuarter-finals O\n\nBoardman B-PER\n4:14.784 O\ncaught O\nEdouard B-PER\nGritson I-PER\n( O\nRussia B-LOC\n) O\n\nFrancis B-PER\nMoreau I-PER\n( O\nFrance B-LOC\n) O\n4:16.274 O\nbeat O\nHeiko B-PER\nSzonn I-PER\n( O\nGermany B-LOC\n) O\n\n4:21.715 O\n\nAndrea B-PER\nCollinelli I-PER\n( O\nItaly B-LOC\n) O\n4:17.551 O\nbeat O\nMichael B-PER\nSandstod I-PER\n\n( O\nDenmark B-LOC\n) O\n4:24.660 O\n\nAlexei B-PER\nMarkov I-PER\n( O\nRussia B-LOC\n) O\n4:19.762 O\nbeat O\nMariano B-PER\nFriedick I-PER\n( O\nU.S. B-LOC\n) O\n\n4:20.241 O\n\none O\nkilometre O\ntime-trial O\nfinal O\n\n1. O\nShane B-PER\nKelly I-PER\n( O\nAustralia B-LOC\n) O\n1 O\nminute O\n02.777 O\nseconds O\n\n2. O\nSoren B-PER\nLausberg I-PER\n( O\nGermany B-LOC\n) O\n1:02.795 O\n\n3. O\nJan B-PER\nVan I-PER\nEiden I-PER\n( O\nGermany B-LOC\n) O\n1:04.541 O\n\n4. O\nHerve B-PER\nThuet I-PER\n( O\nFrance B-LOC\n) O\n1:04.732 O\n\n5. O\nGrzegorz B-PER\nKrejner I-PER\n( O\nPoland B-LOC\n) O\n1:04.834 O\n\n6. O\nAinars B-PER\nKiksis I-PER\n( O\nLatvia B-LOC\n) O\n1:04.896 O\n\n7. O\nDimitrios B-PER\nGeorgalis I-PER\n( O\nGreece B-LOC\n) O\n1:05.022 O\n\n8. O\nJose B-PER\nMoreno I-PER\n( O\nSpain B-LOC\n) O\n1:05.219 O\n\n9. O\nKeiji B-PER\nKojima I-PER\n( O\nJapan B-LOC\n) O\n1:05.300 O\n\n10. O\nGraham B-PER\nSharman I-PER\n( O\nAustralia B-LOC\n) O\n1:05.406 O\n\n11. O\nJose B-PER\nEscuredo I-PER\n( O\nSpain B-LOC\n) O\n1:05.731 O\n\n12. O\nCraig B-PER\nMacLean I-PER\n( O\nBritain B-LOC\n) O\n1:05.735 O\n\n13. O\nChristian B-PER\nMeidlinger I-PER\n( O\nAustria B-LOC\n) O\n1:05.850 O\n\n14. O\nDarren B-PER\nMcKenzie-Potter I-PER\n( O\nNew B-LOC\nZealand I-LOC\n) O\n1:06.289 O\n\n15. O\nMasanaga B-PER\nShiohara I-PER\n( O\nJapan B-LOC\n) O\n1:06.615 O\n\n16. O\nJean-Pierre B-PER\nVan I-PER\nZyl I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n1:07.258 O\n\nKeirin B-LOC\nfinal O\n\n1. O\nMarty B-PER\nNothstein I-PER\n( O\nU.S. B-LOC\n) O\n, O\nlast O\n200 O\nmetres O\nin O\n10.982 O\nseconds O\n. O\n\n2. O\nGary B-PER\nNeiwand I-PER\n( O\nAustralia B-LOC\n) O\n\n3. O\nFrederic B-PER\nMagne I-PER\n( O\nFrance B-LOC\n) O\n\n4. O\nPavel B-PER\nBuran I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\n\n5. O\nMichael B-PER\nHubner I-PER\n( O\nGermany B-LOC\n) O\n\n6. O\nLaurent B-PER\nGane I-PER\n( O\nFrance B-LOC\n) O\n\nMadison B-LOC\nfinal O\n( O\n50 O\nkms O\n) O\n\n1. O\nSilvio B-PER\nMartinelli I-PER\n- O\nMarco B-PER\nVilla I-PER\n( O\nItaly B-LOC\n) O\n34 O\npoints O\n, O\nin O\na O\n\ntime O\nof O\n55 O\nminutes O\n47.4 O\nseconds O\n\n2. O\nScott B-PER\nMcGrory I-PER\n- O\nStephen B-PER\nPate I-PER\n( O\nAustralia B-LOC\n) O\n25 O\n\n3. O\nAndreas B-PER\nKappes I-PER\n- O\nCarsten B-PER\nWolf I-PER\n( O\nGermany B-LOC\n) O\n23 O\n\n4. O\nKurt B-PER\nBetschart I-PER\n- O\nBruno B-PER\nRisi I-PER\n( O\nSwitzerland B-LOC\n) O\n22 O\n\n5. O\nGabriel B-PER\nCuruchet I-PER\n- O\nJuan B-PER\nCuruchet I-PER\n( O\nArgentine B-MISC\n) O\n15 O\n\n6. O\nPeter B-PER\nPieters I-PER\n- O\nTomas B-PER\nPost I-PER\n( O\nNetherlands B-LOC\n) O\n14 O\n\n7. O\nJ B-PER\nimmi I-PER\nMadsen I-PER\n- O\nJens B-PER\nVeggerby I-PER\n( O\nDenmark B-LOC\n) O\n14 O\n\n8. O\nIsaac B-PER\nGalvez-Lopez I-PER\n- O\nJuan B-PER\nLlaneras I-PER\n( O\nSpain B-LOC\n) O\n11 O\n\n9. O\nWolfgang B-PER\nKotzmann I-PER\n- O\nFranz B-PER\nStocher I-PER\n( O\nAustria B-LOC\n) O\n5 O\n\n10. O\nChristophe B-PER\nCapelle I-PER\n- O\nJean-Michel B-PER\nMonin I-PER\n( O\nFrance B-LOC\n) O\n2 O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nBOARDMAN B-PER\nFULFILS O\nWORLD O\nRECORD O\nPREDICTION O\n. O\n\nMartin B-PER\nAyres I-PER\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-28 O\n\nBritain B-LOC\n's O\nChris B-PER\nBoardman I-PER\nfulfilled O\nhis O\nprediction O\nthat O\nhe O\nwould O\nbreak O\nthe O\nworld O\n4,000 O\nmetres O\nworld O\nrecord O\nin O\nthe O\nworld O\ntrack O\ncycling O\nchampionships O\non O\nWednesday O\n. O\n\nBoardman B-PER\nclocked O\nfour O\nminutes O\n13.353 O\nseconds O\nto O\nslice O\nmore O\nthan O\nsix O\nseconds O\nfrom O\nthe O\nprevious O\nworld O\nmark O\nof O\n4:19.699 O\nset O\nby O\nOlympic B-MISC\nchampion O\nAndrea B-PER\nCollinelli I-PER\nof O\nItaly B-LOC\nin O\nAtlanta B-LOC\nin O\nJuly O\n. O\n\nCollinelli B-PER\nqualified O\nin O\nsecond O\nplace O\n, O\nalso O\nbeating O\nhis O\nold O\nrecord O\nin O\n4:17.696 O\n. O\n\n\" O\nI O\nwas O\nvery O\nnervous O\nbefore O\nthe O\nstart O\nbut O\nthen O\nI O\nwas O\namazed O\nby O\nthe O\nspeed O\nof O\nmy O\nride O\n, O\n\" O\nBoardman B-PER\nsaid O\n. O\n\" O\n\nI O\ndo O\nn't O\nknow O\nif O\nI O\ncan O\ngo O\nany O\nfaster O\n. O\n\nWho O\nknows O\nwhat O\nwill O\nhappen O\nin O\nthe O\nlater O\nstages O\n? O\n\" O\n\nBoardman B-PER\n, O\n28 O\n, O\ndid O\nnot O\ncontest O\nthe O\nOlympic B-MISC\npursuit O\nbecause O\nof O\nits O\nproximity O\nto O\nthe O\nTour B-MISC\nde I-MISC\nFrance I-MISC\nin O\nwhich O\nhe O\nled O\nthe O\nFrench B-MISC\nGAN B-ORG\nteam O\n. O\n\nHowever O\n, O\nhe O\ntook O\na O\nbronze O\nmedal O\nin O\nthe O\nOlympic B-MISC\nroad O\ntime-trial O\nand O\nthen O\nreturned O\nhome O\nto O\nprepare O\nfor O\nthe O\nworld O\ntrack O\nseries O\nin O\nthe O\nManchester B-LOC\nindoor O\nvelodrome O\n. O\n\nHe O\nadopted O\nthe O\n\" O\nsuperman O\n\" O\nriding O\nposition O\nwith O\narms O\nat O\nfull O\nstretch O\nperfected O\nby O\nfellow O\nBriton B-MISC\nGraeme B-PER\nObree I-PER\n, O\nthe O\n1995 O\nworld O\nchampion O\n, O\nand O\ntaken O\nup O\nin O\nAtlanta B-LOC\nby O\nCollinelli B-PER\n. O\n\nObree B-PER\nwas O\nforced O\nto O\npull O\nout O\nof O\nhis O\ntitle O\ndefence O\nbecause O\nof O\na O\nviral O\ninfection O\n. O\n\nQualifiers O\nfor O\nWednesday O\nevening O\n's O\nquarter-finals O\n: O\n\n1. O\nChris B-PER\nBoardman I-PER\n( O\nBritain B-LOC\n) O\n4:13.353 O\n\n2. O\nAndrea B-PER\nCollinelli I-PER\n( O\nItaly B-LOC\n) O\n4:17.696 O\n\n3. O\nMariano B-PER\nFriedick I-PER\n( O\nU.S. B-LOC\n) O\n4:19.808 O\n\n4. O\nHeiko B-PER\nSzonn I-PER\n( O\nGermany B-LOC\n) O\n4:21.009 O\n\n5. O\nFrancis B-PER\nMoreau I-PER\n( O\nFrance B-LOC\n) O\n4:21.454 O\n\n6. O\nAlexei B-PER\nMarkov I-PER\n( O\nRussia B-LOC\n) O\n4:22.738 O\n\n7. O\nMichael B-PER\nSandstod I-PER\n( O\nDenmark B-LOC\n) O\n4:24.427 O\n\n8. O\nEdouard B-PER\nGritsoun I-PER\n( O\nRussia B-LOC\n) O\n4:26.467 O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nBOARDMAN B-PER\nBREAKS O\nWORLD O\n4,000 O\nMETRES O\nRECORD O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-28 O\n\nBritain B-LOC\n's O\nChris B-PER\nBoardman I-PER\nbroke O\nthe O\nworld O\n4,000 O\nmetres O\ncycling O\nrecord O\nby O\nmore O\nthan O\nsix O\nseconds O\nat O\nthe O\nworld O\nchampionships O\non O\nWednesday O\n. O\n\nBoardman B-PER\nclocked O\nfour O\nminutes O\n13.353 O\nseconds O\nin O\nthe O\nqualifying O\nround O\nof O\nthe O\nindividual O\npursuit O\nevent O\nto O\nbeat O\nthe O\nprevious O\nmark O\nof O\n4:19.699 O\nset O\nby O\nAndrea B-PER\nCollinelli I-PER\nof O\nItaly B-LOC\nat O\nthe O\nAtlanta B-LOC\nOlympics B-MISC\non O\nJuly O\n24 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nResults O\nof O\nEnglish B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatches O\non O\nWednesday O\n: O\n\nBarnsley B-ORG\n3 O\nReading B-ORG\n0 O\n\nStoke B-ORG\n1 O\nBradford B-ORG\n0 O\n\nSwindon B-ORG\n1 O\nOldham B-ORG\n0 O\n\nWolverhampton B-ORG\n1 O\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\n1 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nBarnsley B-ORG\n3 O\n3 O\n0 O\n0 O\n8 O\n2 O\n9 O\n\nStoke B-ORG\n3 O\n3 O\n0 O\n0 O\n5 O\n2 O\n9 O\n\nTranmere B-ORG\n3 O\n2 O\n1 O\n0 O\n6 O\n3 O\n7 O\n\nBolton B-ORG\n3 O\n2 O\n1 O\n0 O\n5 O\n2 O\n7 O\n\nWolverhampton B-ORG\n3 O\n2 O\n1 O\n0 O\n5 O\n2 O\n7 O\n\nQueens B-ORG\nPark I-ORG\nRangers I-ORG\n3 O\n2 O\n1 O\n0 O\n5 O\n3 O\n7 O\n\nNorwich B-ORG\n3 O\n2 O\n0 O\n1 O\n4 O\n3 O\n6 O\n\nIpswich B-ORG\n3 O\n1 O\n1 O\n1 O\n6 O\n4 O\n4 O\n\nBirmingham B-ORG\n2 O\n1 O\n1 O\n0 O\n5 O\n4 O\n4 O\n\nCrystal B-ORG\nPalace I-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n2 O\n4 O\n\nSwindon B-ORG\n3 O\n1 O\n1 O\n1 O\n2 O\n3 O\n4 O\n\nOxford B-ORG\n3 O\n1 O\n0 O\n2 O\n6 O\n3 O\n3 O\n\nBradford B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n3 O\n3 O\n\nHuddersfield B-ORG\n2 O\n1 O\n0 O\n1 O\n3 O\n3 O\n3 O\n\nPortsmouth B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n5 O\n3 O\n\nReading B-ORG\n3 O\n1 O\n0 O\n2 O\n3 O\n8 O\n3 O\n\nMan B-ORG\nCity I-ORG\n3 O\n1 O\n0 O\n2 O\n2 O\n3 O\n3 O\n\nWest B-ORG\nBromwich I-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n3 O\n2 O\n\nPort B-ORG\nVale I-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n4 O\n2 O\n\nSheffield B-ORG\nUnited I-ORG\n2 O\n0 O\n1 O\n1 O\n4 O\n5 O\n1 O\n\nGrimsby B-ORG\n3 O\n0 O\n1 O\n2 O\n4 O\n7 O\n1 O\n\nCharlton B-ORG\n2 O\n0 O\n1 O\n1 O\n1 O\n3 O\n1 O\n\nSouthend B-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n7 O\n1 O\n\nOldham B-ORG\n3 O\n0 O\n0 O\n3 O\n2 O\n6 O\n0 O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLISH B-MISC\nCOUNTY B-MISC\nCHAMPIONSHIP I-MISC\nSCORES O\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nClose O\nof O\nplay O\nscores O\non O\nthe O\nfirst O\n\nday O\nof O\nfour-day O\nEnglish B-MISC\nCounty B-MISC\nChampionship I-MISC\ncricket O\nmatches O\non O\n\nWednesday O\n: O\n\nAt O\nPortsmouth B-LOC\n: O\nMiddlesex B-ORG\n199 O\nin O\n60 O\novers O\n( O\nK. B-PER\nBrown I-PER\n57 O\n; O\n\nL. B-PER\nBotham I-PER\n5-67 O\n) O\n. O\n\nHampshire B-ORG\n105-4 O\n. O\n\nAt O\nChester-le-Street B-LOC\n: O\nGlamorgan B-ORG\n73-3 O\nv O\nDurham B-ORG\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFOWLER B-PER\nAND O\nMCMANAMAN B-PER\nOUT O\nOF O\nENGLAND B-LOC\nSQUAD O\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nEngland B-LOC\nsoccer O\nmanager O\nGlen B-PER\nHoddle I-PER\nconfirmed O\non O\nWednesday O\nthat O\nthe O\nLiverpool B-ORG\npair O\nof O\nSteve B-PER\nMcManaman I-PER\nand O\nRobbie B-PER\nFowler I-PER\nwould O\nmiss O\nEngland B-LOC\n's O\nWorld B-MISC\nCup I-MISC\nqualifying O\nmatch O\nagainst O\nMoldova B-LOC\non O\nSunday O\n. O\n\nThe O\ntwo O\nmen O\n, O\nboth O\nsuffering O\nfrom O\nback O\ninjuries O\n, O\njoined O\nthe O\nEngland B-LOC\nsquad O\nat O\ntraining O\nbut O\nit O\nwas O\nsoon O\nclear O\nthey O\nhad O\nno O\nchance O\nof O\nmaking O\nthe O\nflight O\nto O\nKishinev B-LOC\non O\nFriday O\n. O\n\n\" O\nThey O\nhad O\nsome O\nscans O\nand O\nX-rays O\nyesterday O\nand O\nthey O\n're O\nout O\n, O\n\" O\nsaid O\nHoddle B-PER\n. O\n\n\" O\nThe O\nmore O\nimportant O\nthing O\nfor O\nme O\nwas O\nto O\nget O\nthem O\ndown O\nhere O\nand O\nhave O\na O\nchat O\n. O\n\nTo O\ngo O\nanother O\nfive O\nweeks O\nwithout O\nthat O\nchance O\nwould O\nhave O\nbeen O\nfoolish O\n, O\n\" O\nhe O\nadded O\n. O\n\nHoddle B-PER\n, O\nwho O\nhas O\nalready O\nlost O\nthe O\nservices O\nof O\nmidfielder O\nDarren B-PER\nAnderton I-PER\nand O\ndefender O\nSteve B-PER\nHowey I-PER\n, O\ndelayed O\nnaming O\nany O\nreplacements O\n. O\n\nThere O\nwas O\nalso O\nconcern O\nover O\ninjuries O\nto O\nPaul B-PER\nGascoigne I-PER\n, O\nLes B-PER\nFerdinand I-PER\nand O\nDavid B-PER\nBatty I-PER\n. O\n\n-DOCSTART- O\n\nHORSE O\nRACING O\n- O\nJOCKEY O\nWEAVER B-PER\nRECEIVES O\n21-DAY O\nBAN B-PER\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nLeading O\nrider O\nJason B-PER\nWeaver I-PER\nreceived O\na O\n21-day O\nban O\nfrom O\nthe O\ndisciplinary O\ncommittee O\nof O\nthe O\nJockey B-ORG\nClub I-ORG\non O\nWednesday O\n. O\n\nWeaver B-PER\nhad O\nbeen O\nreported O\nafter O\nbeing O\nfound O\nguilty O\nof O\nirresponsible O\nriding O\nat O\nthe O\nprovincial O\ntrack O\nof O\nPontefract B-LOC\n10 O\ndays O\nago O\n. O\n\nIt O\nwas O\nhis O\nfourth O\nriding O\noffence O\nthis O\nseason O\n. O\n\nAlthough O\nfive O\ndays O\nof O\nthe O\nban O\nwere O\nsuspended O\nuntil O\nJanuary O\n1 O\n, O\nWeaver B-PER\nwill O\nmiss O\nnext O\nmonth O\n's O\nbig O\nSt B-ORG\nLeger I-ORG\nmeeting O\n, O\nincluding O\nthe O\nride O\non O\ntop O\nstayer O\nDouble B-PER\nTrigger I-PER\nin O\nthe O\nDoncaster B-MISC\nCup I-MISC\n. O\n\nWeaver B-PER\nshot O\nto O\nprominence O\nin O\n1994 O\nwhen O\nhe O\nwon O\nthe O\nEnglish B-MISC\n2,000 B-MISC\nGuineas I-MISC\non O\nMister B-LOC\nBaileys I-LOC\nin O\nhis O\nfirst O\nride O\nin O\na O\nclassic O\n. O\n\n-DOCSTART- O\n\nROWING O\n- O\nREDGRAVE B-PER\nMAY O\nSEEK O\nFIFTH O\nOLYMPIC B-MISC\nGOLD O\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nBritain B-LOC\n's O\nSteven B-PER\nRedgrave I-PER\nsaid O\non O\nWednesday O\nhe O\nmight O\nchange O\nhis O\nmind O\nand O\ngo O\nfor O\na O\nfifth O\nconsecutive O\nOlympic B-MISC\ngold O\nmedal O\nat O\nthe O\n2000 B-ORG\nGames I-ORG\nin O\nSydney B-LOC\n. O\n\nRedgrave B-PER\nis O\none O\nof O\nonly O\nfive O\nathletes O\nwho O\nhave O\nwon O\ngold O\nmedals O\nat O\nfour O\nsuccessive O\nOlympics B-MISC\n. O\n\nHe O\nshared O\nvictory O\nwith O\nMatthew B-PER\nPinsent I-PER\nin O\nthe O\ncoxless O\npairs O\nat O\nthe O\nAtlanta B-MISC\nGames I-MISC\nand O\nsaid O\nat O\nthe O\ntime O\nthat O\nwould O\nbe O\nhis O\nlast O\nshot O\n. O\n\nBut O\nhe O\nhas O\nhad O\nsecond O\nthoughts O\nsince O\nthen O\n. O\n\" O\n\nI O\n'm O\nonly O\n34 O\n. O\n\nSome O\nsay O\nthat O\n's O\ntoo O\nold O\nfor O\nan O\nathlete O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nBut O\nI O\n'll O\nbe O\n38 O\nby O\nSydney B-LOC\nand O\nthat O\n's O\nnot O\ntoo O\nold O\n. O\n\nIt O\n's O\nwhether O\nI O\nhave O\ngot O\nthe O\nenthusiasm O\nfor O\nthe O\ntraining O\nover O\nthe O\nnext O\nfour O\nyears O\n. O\n\nRowing O\nis O\nan O\nendurance O\nsport O\n. O\n\" O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nBOTHAM B-PER\nDISMISSES O\nGATTING B-PER\nIN O\nFIRST O\nCLASS O\nDEBUT O\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nLiam B-PER\nBotham I-PER\ndemonstrated O\nhis O\nfather O\nIan B-PER\n's O\ngolden O\ntouch O\non O\nWednesday O\nshortly O\nafter O\nmaking O\nhis O\ncounty O\ndebut O\nfor O\nHampshire B-ORG\n. O\n\nBotham B-PER\ndismissed O\nMike B-PER\nGatting I-PER\nwith O\nhis O\nseventh O\nball O\nwhen O\nthe O\nformer O\nEngland B-LOC\ncaptain O\npushed O\na O\nhalf-volley O\nto O\nsquare-leg O\non O\nthe O\nfirst O\nday O\nof O\nthe O\nfour-day O\nmatch O\nagainst O\nMiddlesex B-ORG\nat O\nPortsmouth B-LOC\n. O\n\nEarlier O\nBotham B-PER\narrived O\nin O\nPortsmouth B-LOC\nfrom O\nSouthampton B-LOC\nonly O\nto O\nbe O\ntold O\nhis O\nservices O\nwould O\nnot O\nbe O\nrequired O\n. O\n\nHe O\nthen O\ndrove O\n40 O\nkms O\nback O\nto O\nplay O\nfor O\nthe O\nsecond O\nXI O\nto O\nlearn O\nthat O\nJohn B-PER\nStephenson I-PER\nhad O\ndropped O\nout O\nof O\nthe O\nMiddlesex B-ORG\nmatch O\nin O\nthe O\nmeantime O\nwith O\na O\nshoulder O\ninjury O\n. O\n\nBotham B-PER\ndashed O\nback O\nto O\nPortsmouth B-LOC\nand O\ntook O\nthe O\nfield O\nas O\nthe O\nthrid O\nover O\nbegan O\n. O\n\nIan B-PER\nBotham I-PER\nbegan O\nhis O\ntest O\ncareer O\nin O\n1977 O\nby O\ndismissing O\nAustralian B-MISC\ncaptain O\nGreg B-PER\nChappell I-PER\nwith O\na O\nlong O\nhop O\nand O\nwent O\non O\nto O\nbecome O\nhis O\ncountry O\n's O\nmost O\nsuccessful O\nall-rounder O\never O\nwith O\n5,200 O\nruns O\n, O\n383 O\nwickets O\nplus O\n120 O\ncatches O\nin O\n102 O\ntests O\n. O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nCARLING B-PER\nLEFT O\nOUT O\nOF O\nENGLAND B-LOC\nTRAINING O\nSQUAD O\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nFormer O\nEngland B-LOC\ncaptain O\nWill B-PER\nCarling I-PER\nalong O\nwith O\nJeremy B-PER\nGuscott I-PER\n, O\nRory B-PER\nUnderwood I-PER\nand O\nDean B-PER\nRichards I-PER\nhave O\nbeen O\nleft O\nout O\nof O\nEngland B-LOC\n's O\nfirst O\ntraining O\nsquad O\nof O\nthe O\nseason O\n. O\n\nThe O\nquartet O\n, O\nwho O\npossess O\n244 O\ninternational O\ncaps O\nbetween O\nthem O\n, O\nwere O\nalso O\nomitted O\nfrom O\na O\nsummer O\ntraining O\ncamp O\nbut O\nwill O\nstill O\nbe O\nin O\ncontention O\nwhen O\nthe O\nnorthern O\ninternational O\nseason O\nstarts O\nlater O\nthis O\nyear O\n. O\n\n\" O\nTheir O\nqualities O\nare O\nwell O\nknown O\nto O\nthe O\nselectors O\nand O\nthey O\nwill O\n, O\nof O\ncourse O\n, O\nbe O\nconsidered O\nwhen O\nthe O\nseason O\ngets O\nunderway O\n, O\n\" O\nthe O\nRugby B-ORG\nFootball I-ORG\nUnion I-ORG\nsaid O\nin O\na O\nstatement O\non O\nWednesday O\n. O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nDODGERS B-ORG\nWIN O\nFIFTH O\nSTRAIGHT O\n. O\n\nMONTREAL B-LOC\n1996-08-28 O\n\nHideo B-PER\nNomo I-PER\nallowed O\na O\nrun O\nin O\nseven O\ninnings O\nfor O\nhis O\nfifth O\nwin O\nin O\nseven O\nroad O\nstarts O\nand O\nGreg B-PER\nGagne I-PER\ncapped O\na O\nthree-run O\nfourth O\nwith O\na O\ntwo-run O\nhomer O\nas O\nthe O\nLos B-ORG\nAngeles I-ORG\nDodgers I-ORG\nclaimed O\na O\n5-1 O\nvictory O\nthe O\nMontreal B-ORG\nExpos I-ORG\non O\nTuesday O\n. O\n\nWith O\ntheir O\nfifth O\nstraight O\nwin O\n, O\nthe O\nDodgers B-ORG\nmoved O\na O\nhalf-game O\nahead O\nof O\nthe O\nExpos B-ORG\nat O\nthe O\ntop O\nof O\nthe O\nwild O\ncard O\nhunt O\nbehind O\nNomo B-PER\n( O\n13-10 O\n) O\n, O\nwho O\nallowed O\nsix O\nhits O\nand O\nwalked O\nfour O\nwith O\nsix O\nstrikeouts O\n. O\n\nIn O\nSan B-LOC\nFrancisco I-LOC\n, O\nMike B-PER\nWilliams I-PER\nallowed O\ntwo O\nruns O\nin O\n7-1/3 O\ninnings O\nand O\nBenito B-PER\nSantiago I-PER\nand O\nRuben B-PER\nAmaro I-PER\nhad O\nRBI B-MISC\nhits O\nin O\nthe O\nfirst O\ninning O\nas O\nthe O\nPhiladelphia B-ORG\nPhillies I-ORG\nedged O\nthe O\nSan B-ORG\nFrancisco I-ORG\nGiants I-ORG\n3-2 O\n. O\n\nWilliams B-PER\n( O\n5-12 O\n) O\n, O\nwho O\nsnapped O\na O\npersonal O\nthree-game O\nlosing O\nstreak O\n, O\nallowed O\nfive O\nhits O\n, O\nwalked O\ntwo O\nand O\nstruck O\nout O\nfive O\n. O\n\nIt O\nwas O\nalso O\nWilliams B-PER\n' O\nfirst O\nwin O\nin O\nthree O\ncareer O\ndecisions O\nagainst O\nSan B-LOC\nFrancisco I-LOC\n. O\n\nIn O\nPittsburgh B-LOC\n, O\nAl B-PER\nMartin I-PER\n's O\nrun-scoring O\nsingle O\nsnapped O\na O\nfifth-inning O\ntie O\nand O\nDenny B-PER\nNeagle I-PER\noutdueled O\nJohn B-PER\nSmoltz I-PER\nas O\nthe O\nPittsburgh B-ORG\nPirates I-ORG\nedged O\nthe O\nAtlanta B-ORG\nBraves I-ORG\n3-2 O\n. O\n\nThe O\nBraves B-ORG\nled O\n2-1 O\nentering O\nthe O\nfifth O\n, O\nbut O\nthe O\nPirates B-ORG\npushed O\nacross O\ntwo O\nruns O\nagainst O\nSmoltz B-PER\n( O\n20-7 O\n) O\n. O\n\nNeagle B-PER\n( O\n14-6 O\n) O\nbeat O\nthe O\nBraves B-ORG\nfor O\nthe O\nthird O\ntime O\nthis O\nseason O\n, O\nallowing O\ntwo O\nruns O\nand O\nsix O\nhits O\nin O\neight O\ninnings O\n. O\n\nIn O\nSt B-LOC\nLouis I-LOC\n, O\nGary B-PER\nSheffield I-PER\nand O\nDevon B-PER\nWhite I-PER\neach O\ndrove O\nin O\ntwo O\nruns O\nand O\nMark B-PER\nHutton I-PER\nscattered O\nfour O\nhits O\nover O\nsix O\ninnings O\nto O\nlead O\nthe O\nFlorida B-ORG\nMarlins I-ORG\npast O\nthe O\nSt. B-ORG\nLouis I-ORG\nCardinals I-ORG\n6-3 O\n. O\n\nWhite B-PER\nadded O\na O\nsolo O\nhomer O\n, O\nhis O\n11th O\n, O\noff O\nreliever O\nMark B-PER\nPetkovsek I-PER\nwith O\none O\nout O\nin O\nthe O\nfifth O\n, O\ngiving O\nthe O\nMarlins B-ORG\na O\n6-0 O\nlead O\n. O\n\nIn O\nNew B-LOC\nYork I-LOC\n, O\nSteve B-PER\nFinley I-PER\n's O\nthree-run O\nhomer O\ncapped O\na O\nfour-run O\neighth O\ninning O\nand O\ngave O\nthe O\nSan B-ORG\nDiego I-ORG\nPadres I-ORG\na O\n4-3 O\nvictory O\nover O\nNew B-LOC\nYork I-LOC\n, O\nspoiling O\nBobby B-PER\nValentine I-PER\n's O\ndebut O\nas O\nMets B-ORG\n' O\nmanager O\n. O\n\nThe O\nrally O\nmade O\na O\nwinner O\nout O\nof O\nreliever O\nWillie B-PER\nBlair I-PER\n\nTony B-PER\nGwynn I-PER\nand O\nWally B-PER\nJoyner I-PER\nhad O\ntwo O\nhits O\napiece O\n, O\nhelping O\nthe O\nPadres B-ORG\nto O\ntheir O\nthird O\nstraight O\nwin O\n. O\n\nFirst-place O\nSan B-ORG\nDiego I-ORG\nhas O\nwon O\nseven O\nof O\nits O\nlast O\neight O\ngames O\nand O\nimproved O\nto O\n34-20 O\nagainst O\nNL B-MISC\nEast I-MISC\nopponents O\n. O\n\nIn O\nHouston B-LOC\n, O\nTony B-PER\nEusebio I-PER\n's O\neighth-inning O\nsacrifice O\nfly O\ncapped O\na O\ncomeback O\nfrom O\na O\nfive-run O\ndeficit O\nthat O\ngave O\nthe O\nHouston B-ORG\nAstros I-ORG\na O\n6-5 O\nvictory O\nover O\nthe O\nChicago B-ORG\nCubs I-ORG\n. O\n\nThe O\nAstros B-ORG\ntrailed O\n5-0 O\nafter O\nthree O\ninnings O\n, O\nbut O\nscored O\nthree O\nruns O\nin O\nthe O\nfourth O\nand O\none O\nin O\nthe O\nsixth O\nbefore O\ntaking O\nthe O\nlead O\nin O\nthe O\neighth O\n. O\n\nIn O\nSt B-LOC\nLouis I-LOC\n, O\nGary B-PER\nSheffield I-PER\nand O\nDevon B-PER\nWhite I-PER\neach O\ndrove O\nin O\ntwo O\nruns O\nand O\nMark B-PER\nHutton I-PER\nscattered O\nfour O\nhits O\nover O\nsix O\ninnings O\nto O\nlead O\nthe O\nFlorida B-ORG\nMarlins I-ORG\npast O\nthe O\nSt. B-ORG\nLouis I-ORG\nCardinals I-ORG\n, O\n6-3 O\n, O\n\nSheffield B-PER\n, O\nwho O\nwas O\nbenched O\nMonday O\n, O\ndelivered O\na O\ndouble O\ndown O\nthe O\nleft-field O\nline O\nin O\nthe O\nfirst O\n, O\nscoring O\nLuis B-PER\nCastilla I-PER\nand O\nAlex B-PER\nArias I-PER\nto O\nput O\nthe O\nMarlins B-ORG\nahead O\nto O\nstay O\n. O\n\nAt O\nColorado B-LOC\n, O\nHal B-PER\nMorris I-PER\nand O\nEric B-PER\nDavis I-PER\neach O\nhomered O\nand O\nJohn B-PER\nSmiley I-PER\nscattered O\nsix O\nhits O\nover O\n6 O\n2/3 O\ninnings O\nas O\nthe O\nCincinnati B-ORG\nReds I-ORG\ndefeated O\nthe O\nColorado B-ORG\nRockies I-ORG\n4-3 O\n, O\nsnapping O\na O\nfour-game O\nlosing O\nstreak O\n. O\n\nThe O\nReds B-ORG\ntook O\na O\none-run O\nlead O\nin O\nthe O\nsecond O\ninning O\nwhen O\nMorris B-PER\nled O\noff O\nwith O\nhis O\n10th O\nhomer O\noff O\nstarter O\nArmando B-PER\nReynoso I-PER\n( O\n8-9 O\n) O\n. O\n\nThey O\nincreased O\ntheir O\nbulge O\nto O\n4-0 O\nin O\nthe O\nthird O\nwhen O\nBarry B-PER\nLarkin I-PER\ndrew O\na O\none-out O\nwalk O\n, O\nKevin B-PER\nMitchell I-PER\nsingled O\nand O\nDavis B-PER\nlaunched O\nhis O\n22nd O\nhomer O\nover O\nthe O\nright-field O\nwall O\n. O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nNEW B-LOC\nZEALAND I-LOC\nRECALL O\nMEHRTENS B-PER\nFOR O\nFINAL O\nTEST O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-28 O\n\nThe O\nNew B-LOC\nZealand I-LOC\nrugby O\nselectors O\nrecalled O\nfly-half O\nAndrew B-PER\nMehrtens I-PER\non O\nWednesday O\nwhen O\nthey O\nannounced O\ntheir O\nteam O\nfor O\nthe O\nthird O\nand O\nfinal O\ntest O\nin O\nJohannesburg B-LOC\non O\nSaturday O\n. O\n\nHe O\nreturns O\nin O\nplace O\nof O\nSimon B-PER\nCulhane I-PER\nwho O\nbroke O\na O\nwrist O\nin O\nthe O\nAll B-ORG\nBlacks I-ORG\n' O\nseries-clinching O\nvictory O\nin O\nPretoria B-LOC\non O\nSaturday O\n. O\n\nMehrtens B-PER\nplayed O\nin O\nthe O\nlast O\nTriNations B-MISC\ntest O\nin O\nCape B-LOC\nTown I-LOC\nbut O\nmissed O\nthe O\nfirst O\ntwo O\ntests O\nin O\nthe O\ncurrent O\nseries O\nafter O\ntearing O\na O\ncartilage O\nin O\nhis O\nknee O\nwhile O\ntraining O\n, O\nan O\ninjury O\nwhich O\nneeded O\na O\nsmall O\noperation O\n. O\n\nLock O\nIan B-PER\nJones I-PER\nand O\nwing O\nJeff B-PER\nWilson I-PER\nhave O\nalso O\nbeen O\nnamed O\nin O\nthe O\nteam O\ndespite O\ndoubts O\nover O\ntheir O\nfitness O\n. O\n\nJones B-PER\nhas O\na O\nknee O\ninjury O\nwhile O\nWilson B-PER\nis O\nsuffering O\nfrom O\na O\nviral O\ninfection O\n. O\n\nBlair B-PER\nLarsen I-PER\nor O\nthe O\nuncapped O\nGlenn B-PER\nTaylor I-PER\nare O\non O\nstandby O\nto O\nreplace O\nJones B-PER\nand O\n, O\nwith O\nJonah B-PER\nLomu I-PER\nout O\nof O\naction O\nwith O\na O\nshoulder O\ninjury O\npicked O\nup O\nin O\nTuesday O\n's O\ndrawn O\nmatch O\nagainst O\nGriqualand B-ORG\nWest I-ORG\n, O\nEric B-PER\nRush I-PER\nis O\nfavourite O\nto O\nplay O\nshould O\nWilson B-PER\nfail O\nto O\nrecover O\n. O\n\nTeam O\n: O\n\n15 O\n- O\nChristian B-PER\nCullen I-PER\n, O\n14 O\n- O\nJeff B-PER\nWilson I-PER\n, O\n13 O\n- O\nWalter B-PER\nLittle I-PER\n, O\n12 O\n- O\nFrank B-PER\nBunce I-PER\n, O\n11 O\n- O\nGlen B-PER\nOsborne I-PER\n; O\n10 O\n- O\nAndrew B-PER\nMehrtens I-PER\n, O\n9 O\n- O\nJustin B-PER\nMarshall I-PER\n; O\n8 O\n- O\nZinzan B-PER\nBrooke I-PER\n, O\n7 O\n- O\nJosh B-PER\nKronfeld I-PER\n, O\n6 O\n- O\nMichael B-PER\nJones I-PER\n, O\n5 O\n- O\nIan B-PER\nJones I-PER\n, O\n4 O\n- O\nRobin B-PER\nBrooke I-PER\n, O\n3 O\n- O\nOlo B-PER\nBrown I-PER\n, O\n2 O\n- O\nSean B-PER\nFitzpatrick I-PER\n( O\ncaptain O\n) O\n, O\n1 O\n- O\nCraig B-PER\nDowd I-PER\n. O\n\n-DOCSTART- O\n\nHOCKEY O\n- O\nBONNET B-PER\nTAKES O\nOVER O\nAS O\nSOUTH O\nAFRICAN O\nCOACH O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-28 O\n\nFormer O\nSouth B-MISC\nAfrican I-MISC\ncaptain O\nGiles B-PER\nBonnet I-PER\nwas O\nnamed O\nby O\nthe O\nSouth B-ORG\nAfrican I-ORG\nHockey I-ORG\nAssociation I-ORG\non O\nWednesday O\nas O\nthe O\nnew O\ncoach O\nof O\nthe O\nmen O\n's O\nnational O\nside O\n. O\n\nBonnet B-PER\n, O\nwho O\nhas O\nbeen O\ncoaching O\nthe O\nKwazulu-Natal B-LOC\nprovincial O\nteam O\n, O\ntakes O\nover O\nfrom O\nEnglishman B-MISC\nGavin B-PER\nFeatherstone I-PER\nwho O\ntook O\nSouth B-LOC\nAfrica I-LOC\nto O\n10th O\nplace O\nin O\nthe O\nOlympic B-MISC\nGames I-MISC\nin O\nAtlanta B-LOC\n. O\n\nFeatherstone B-PER\n, O\na O\nformer O\nBritain B-LOC\ncaptain O\n, O\nhas O\naccepted O\na O\ncoaching O\nposition O\nwith O\na O\nwomen O\n's O\nteam O\nin O\nIreland B-LOC\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nGIBBS B-PER\nGETS O\nINTERNATIONAL O\nCALL O\nUP O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-28 O\n\nWestern B-ORG\nProvince I-ORG\nbatsman O\nHerschelle B-PER\nGibbs I-PER\nwas O\nthe O\nonly O\nuncapped O\nplayer O\nin O\nSouth B-LOC\nAfrica I-LOC\n's O\n14-man O\nsquad O\nnamed O\non O\nWednesday O\nfor O\na O\nquadrangular O\none-day O\nseries O\nin O\nKenya B-LOC\nnext O\nmonth O\n. O\n\nKenya B-LOC\n, O\nSouth B-LOC\nAfrica I-LOC\n, O\nPakistan B-LOC\nand O\nSri B-LOC\nLanka I-LOC\nwill O\ntake O\npart O\nin O\nthe O\nseries O\n. O\n\nNational O\ncoach O\nBob B-PER\nWoolmer I-PER\nsaid O\nGibbs B-PER\n, O\n22 O\n, O\nhad O\nbeen O\nrewarded O\nfor O\na O\ntremendous O\ntour O\nof O\nEngland B-LOC\nwith O\nthe O\nSouth B-MISC\nAfrican I-MISC\nA O\nteam O\nearlier O\nthis O\nyear O\n. O\n\n\" O\nI O\n've O\nknown O\nHerschelle B-PER\nsince O\nhe O\nwas O\n11 O\nyears O\nold O\nand O\nhe O\nshowed O\nin O\nEngland B-LOC\nhow O\nhe O\nhas O\nmatured O\n. O\n\nHis O\n170 O\nagainst O\nthe O\nMCC B-ORG\nwas O\nan O\ninnings O\nof O\nsupreme O\nclass O\nagainst O\nthe O\nbest O\nbowling O\nattack O\nwe O\nfaced O\nall O\ntour O\n, O\n\" O\nWoolmer B-PER\ntold O\na O\nnews O\nconference O\n. O\n\n. O\n\n\" O\nWe O\nwere O\nnot O\nable O\nto O\nconsider O\nJacques B-PER\nKallis I-PER\n, O\nPaul B-PER\nAdams I-PER\nand O\nShaun B-PER\nPollock I-PER\ndue O\nto O\ninjury O\nand O\nthe O\nreplacements O\nhave O\nall O\ncome O\nfrom O\nthe O\nA O\ntour O\nand O\nit O\n's O\ngreat O\nthat O\nthey O\nare O\nall O\nin O\nform O\n. O\n\" O\n\nSpin-bowling O\nall-rounders O\nNicky B-PER\nBoje I-PER\nand O\nDerek B-PER\nCrookes I-PER\nreplace O\nPollock B-PER\nand O\nAdams B-PER\n, O\nwhile O\nGibbs B-PER\ncomes O\nin O\nfor O\nhis O\nWestern B-ORG\nProvince I-ORG\ncolleague O\nKallis B-PER\n. O\n\nSquad O\n: O\nHansie B-PER\nCronje I-PER\n( O\ncaptain O\n) O\n, O\nCraig B-PER\nMatthews I-PER\n( O\nvice-captain O\n) O\n, O\nDave B-PER\nRichardson I-PER\n, O\nBrian B-PER\nMcMillan I-PER\n, O\nGary B-PER\nKirsten I-PER\n, O\nAndrew B-PER\nHudson I-PER\n, O\nPat B-PER\nSymcox I-PER\n, O\nJonty B-PER\nRhodes I-PER\n, O\nAllan B-PER\nDonald I-PER\n, O\nFanie B-PER\nde I-PER\nVilliers I-PER\n, O\nDaryll B-PER\nCullinan I-PER\n, O\nDerek B-PER\nCrookes I-PER\n, O\nHerschelle B-PER\nGibs I-PER\n, O\nNicky B-PER\nBoje I-PER\n. O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nOLYMPIAKOS B-ORG\nBEAT O\nRED B-ORG\nSTAR I-ORG\n71-57 O\n. O\n\nBELGRADE B-LOC\n1996-08-28 O\n\nOlympiakos B-ORG\nof O\nGreece B-LOC\nbeat O\nYugoslavia B-LOC\n's O\nRed B-ORG\nStar I-ORG\n71-57 O\n( O\nhalftime O\n40-34 O\n) O\nin O\nthe O\nfirst O\nmatch O\nof O\nan O\ninternational O\nclub O\nbasketball O\ntournament O\non O\nWednesday O\n. O\n\nPartizan B-ORG\n( O\nYugoslavia B-LOC\n) O\n, O\nAlba B-ORG\n( O\nGermany B-LOC\n) O\n, O\nDinamo B-ORG\n( O\nRussia B-LOC\n) O\nand O\nBenetton B-ORG\n( O\nItaly B-LOC\n) O\nare O\nalso O\ntaking O\npart O\nin O\nthe O\nevent O\nwhich O\ncontinues O\nuntil O\nSaturday O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nRUSSIA B-LOC\nAND O\nBRAZIL B-LOC\nDRAW O\n2-2 O\nIN O\nFRIENDLY O\n. O\n\nMOSCOW B-LOC\n1996-08-28 O\n\nRussia B-LOC\nand O\nBrazil B-LOC\ndrew O\n2-2 O\n\n( O\nhalftime O\n1-0 O\n) O\nin O\na O\nfriendly O\nsoccer O\ninternational O\non O\nWednesday O\n. O\n\nScorers O\n: O\n\nRussia B-LOC\n- O\nYuri B-PER\nNikiforov I-PER\n( O\n18th O\nminute O\n) O\n, O\nVladislav B-PER\nRodimov I-PER\n\n( O\n80th O\n) O\n\nBrazil B-LOC\n- O\nDonizetti B-PER\n( O\n47th O\n) O\n, O\nRonaldo B-PER\n( O\n85th O\n) O\n\nAttendence O\n: O\n20,000 O\n\n-DOCSTART- O\n\nSQUASH O\n- O\nHONG B-MISC\nOPEN I-MISC\nFIRST O\nROUND O\nRESULTS O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-28 O\n\nFirst O\nround O\nresults O\nin O\nthe O\nHong B-MISC\n\nKong B-MISC\nOpen I-MISC\non O\nWednesday O\n( O\nprefix O\ndenotes O\nseeding O\n) O\n: O\n\n2 O\n- O\nRodney B-PER\nEyles I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nZarak B-PER\nJahan I-PER\nKhan I-PER\n( O\nPakistan B-LOC\n) O\n\n15-6 O\n8-15 O\n15-10 O\n7-15 O\n15-12 O\n\n4 O\n- O\nPeter B-PER\nNicol I-PER\n( O\nScotland B-LOC\n) O\nbeat O\nJulian B-PER\nWellings I-PER\n( O\nEngland B-LOC\n) O\n15-8 O\n\n15-7 O\n15-6 O\n\nDerek B-PER\nRyan I-PER\n( O\nIreland B-LOC\n) O\nbeat O\n5 O\n- O\nSimon B-PER\nParke I-PER\n( O\nEngland B-LOC\n) O\n15-11 O\n15-11 O\n\n2-15 O\n15-11 O\n\n7 O\n- O\nChris B-PER\nWalker I-PER\n( O\nEngland B-LOC\n) O\nbeat O\nJulien B-PER\nBonetat I-PER\n( O\nFrance B-LOC\n) O\n15-12 O\n\n15-6 O\n15-2 O\n\nJonathon B-PER\nPower I-PER\n( O\nCanada B-LOC\n) O\nbeat O\nAhmed B-PER\nBarada I-PER\n( O\nEgypt B-LOC\n) O\n11-15 O\n8-15 O\n\n15-13 O\n15-11 O\n15-2 O\n\nAmr B-PER\nShabana I-PER\n( O\nEgypt B-LOC\n) O\nbeat O\nJohn B-PER\nWhite I-PER\n( O\nAustralia B-LOC\n) O\n10-15 O\n15-9 O\n\n15-10 O\n16-17 O\n15-1 O\n\nPaul B-PER\nJohnson I-PER\n( O\nEngland B-LOC\n) O\nbeat O\nTony B-PER\nHands I-PER\n( O\nEngland B-LOC\n) O\n12-15 O\n15-11 O\n\n7-15 O\n15-6 O\n15-11 O\n\nZubair B-PER\nJahan I-PER\nKhan I-PER\n( O\nPakistan B-LOC\n) O\nbeat O\nFaheem B-PER\nKhan I-PER\n( O\nHong B-LOC\nKong I-LOC\n) O\n12-15 O\n\n15-10 O\n15-10 O\n15-10 O\n\nR O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nFORMULA B-ORG\nSHELL I-ORG\nWIN O\nGAME O\nONE O\nIN O\nPHILIPPINES O\n. O\n\nMANILA B-LOC\n1996-08-28 O\n\nResult O\nof O\ngame O\none O\nof O\nthe O\nPhilippine B-ORG\nBasketball I-ORG\nAssociation I-ORG\nsecond O\nconference O\nfinals O\non O\nTuesday O\n: O\n\nFormula B-ORG\nShell I-ORG\nbeat O\nAlaska B-ORG\nMilk I-ORG\n85-82 O\n( O\n36-46 O\n) O\n\n( O\nFormula B-ORG\nShell I-ORG\nleads O\nbest-of-seven O\nseries O\n1-0 O\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nISRAELI B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n. O\n\nJERUSALEM B-LOC\n1996-08-28 O\n\nResults O\nof O\nfirst O\ndivision O\n\nsoccer O\nmatches O\nplayed O\nover O\nthe O\nweekend O\nand O\nTuesday O\n: O\n\nHapoel B-ORG\nKfar I-ORG\nSava I-ORG\n0 O\nHapoel B-ORG\nZafririm I-ORG\nHolon I-ORG\n1 O\n\nHapoel B-ORG\nTel I-ORG\nAviv I-ORG\n1 O\nMaccabi B-ORG\nHaifa I-ORG\n3 O\n\nHapoel B-ORG\nJerusalem I-ORG\n0 O\nHapoel B-ORG\nPetah I-ORG\nTikva I-ORG\n3 O\n\nHapoel B-ORG\nIroni I-ORG\nRishon I-ORG\nLezion O\n3 O\nHapoel B-ORG\nTaibe I-ORG\n1 O\n\nHapoel B-ORG\nBeit I-ORG\nShe'an I-ORG\n0 O\nHapoel B-ORG\nBeit I-ORG\nShe'an I-ORG\n1 O\n\nMaccabi B-ORG\nPetah I-ORG\nTikva I-ORG\n0 O\nBetar B-ORG\nJerusalem I-ORG\n3 O\n\nHapoel B-ORG\nHaifa I-ORG\n3 O\nMaccabi O\nTel B-ORG\nAviv I-ORG\n1 O\n\nHapoel B-ORG\nBeersheva I-ORG\n2 O\nMaccabi B-ORG\nHerzliya I-ORG\n0 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nSELES B-PER\nHAS I-PER\nWALKOVER O\nTO O\nU.S. B-MISC\nOPEN I-MISC\nTHIRD O\nROUND O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nSecond O\nseed O\nand O\nco-world O\nnumber O\none O\nMonica B-PER\nSeles I-PER\nadvanced O\nto O\nthe O\nthird O\nround O\nof O\nthe O\nU.S. B-MISC\nOpen I-MISC\nTennis I-MISC\nChampionships I-MISC\nwithout O\nhitting O\na O\nball O\non O\nWednesday O\n. O\n\nSeles B-PER\n, O\nthe O\n1991 O\nand O\n1992 O\nchampion O\nwho O\ndropped O\njust O\none O\ngame O\nin O\nher O\nopening O\nmatch O\n, O\nwas O\nscheduled O\nto O\nplay O\nLaurence B-PER\nCourtois I-PER\nof O\nBelgium B-LOC\nWednesay O\nnight O\n. O\n\nBut O\ntournament O\nofficials O\nannounced O\nabout O\nfour-and-a-half O\nhours O\nbefore O\nthe O\nmatch O\nthat O\nCourtois B-PER\nhad O\npulled O\nout O\ndue O\nto O\na O\nleft O\nknee O\nbone O\ninflammation O\n, O\nmoving O\nSeles B-PER\ninto O\nthe O\nnext O\nround O\non O\na O\nwalkover O\n. O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nSERIOUS O\nMEDVEDEV B-PER\nIS O\nHAVING O\nFUN O\nAGAIN O\n. O\n\nRichard B-PER\nFinn I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nOutspoken O\nAndrei B-PER\nMedvedev I-PER\nexchanged O\nhis O\nreputation O\nas O\nthe O\nclown O\nprince O\nof O\ntennis O\non O\nWednesday O\nfor O\na O\nnew O\nno-nonsense O\nattitude O\nthat O\nhas O\nmade O\nlife O\non O\nthe O\ncourts O\nfun O\nagain O\n. O\n\n\" O\nI O\nthink O\nI O\n'm O\nmuch O\nmore O\nfocused O\non O\nwhat O\nI O\nhave O\nto O\ndo O\n, O\nand O\nthat O\n's O\nplaying O\ntennis O\n, O\n\" O\nMedvedev B-PER\nsaid O\nafter O\nrouting O\nFrenchman B-MISC\nJean-Philippe B-PER\nFleurian I-PER\n6-2 O\n6-0 O\n6-1 O\nin O\nthe O\nopening O\nround O\nof O\nthe O\nU.S. B-MISC\nOpen I-MISC\n. O\n\nIt O\nwas O\nMedvedev B-PER\n's O\nsixth O\nvictory O\nin O\na O\nrow O\nafter O\nwinning O\nhis O\nfirst O\ntournament O\nof O\nthe O\nyear O\nlast O\nweek O\nat O\nthe O\nHamlet B-MISC\nCup I-MISC\n. O\n\n\" O\nI O\nrealised O\nthis O\nyear O\n, O\nthat O\nwithout O\nputting O\n99.9 O\npercent O\nof O\nyour O\nmind O\ninto O\ntennis O\n, O\nI O\ndo O\nn't O\nthink O\nyou O\ncan O\nsuccessful O\n, O\n\" O\nsaid O\nthe O\n22-year-old O\nMedvedev B-PER\n. O\n\n\" O\nThe O\nwhole O\nday O\nI O\n'm O\nthinking O\nabnout O\ntennis O\n. O\n\nI O\nfelt O\nthat O\nall O\nthe O\nother O\nthings O\nI O\nwas O\ndoing O\nthe O\nyears O\nbefore O\n, O\nthey O\nwere O\ndistracting O\nme O\n, O\nthey O\nwere O\nnot O\nhelping O\nme O\nat O\nall O\n. O\n\" O\n\nFor O\nMedvedev B-PER\nthat O\nmeant O\nconfining O\nhis O\npost-match O\ncomments O\nto O\ntennis O\nand O\nnot O\ngoing O\noff O\non O\ntirades O\nabout O\nabout O\nperipheral O\nissues O\nsuch O\nas O\nthe O\npoor O\nquality O\nof O\nfood O\nin O\nthe O\nplayers O\nlounge O\n, O\nan O\nentertaining O\nrant O\nthat O\ntook O\nhis O\nmind O\noff O\nthe O\ntask O\nat O\nhand O\n. O\n\n\" O\nI O\nknow O\nwhat O\nI O\n'm O\nhere O\nfor O\n, O\n\" O\nsaid O\nMedvedev B-PER\n, O\nwho O\nlost O\nin O\nthe O\nsecond O\nround O\nof O\nthe O\nOpen B-MISC\nthe O\nlast O\ntwo O\nyears O\nafter O\nreaching O\nthe O\nquarters O\nin O\n1993 O\n, O\nthe O\nsame O\nyear O\nhe O\ntried O\nhis O\nhand O\nas O\na O\nrestaurant O\ncritic O\n. O\n\n\" O\nI O\n'm O\nnot O\nhere O\nto O\nfight O\nthe O\npress O\nor O\ntalk O\nabout O\nthe O\nfood O\nor O\nentertain O\nthe O\npeople O\noff O\nthe O\ncourt O\n. O\n\nI O\n'm O\nhere O\nto O\nplay O\ntennis O\nand O\nto O\nwin O\n. O\n\nI O\nhave O\nmuch O\nless O\nfun O\noff O\nthe O\ncourt O\n. O\n\nI O\nhave O\nmuch O\nmore O\nfun O\non O\nthe O\ncourt O\n, O\n\" O\nhe O\nsaid O\n. O\n\nJust O\nthree O\nyears O\nago O\nMedvedev B-PER\nwas O\none O\nof O\nthe O\nworld O\n's O\nbest O\n, O\nwith O\na O\nranking O\nof O\nsix O\nafter O\nreaching O\nthe O\nFrench B-MISC\nOpen I-MISC\nsemifinal O\nand O\nwinning O\nthree O\ntournaments O\n. O\n\nBut O\nMedvedev B-PER\n's O\nranking O\nslowly O\nbegan O\nto O\ndrop O\nlast O\nyear O\nas O\nhe O\nstruggled O\nwith O\na O\nwrist O\ninjury O\n. O\n\nThe O\nUkrainian B-MISC\nfinally O\nhit O\na O\nlow O\nof O\n44th O\ntwo O\nmonths O\nago O\n. O\n\n\" O\nIt O\n's O\nsomewhere O\nwhere O\nI O\nwould O\nn't O\nlike O\nto O\nstay O\nvery O\nlong O\n, O\n\" O\nMedvedev B-PER\nsaid O\nof O\nhis O\ncurrent O\nranking O\nof O\n36 O\n. O\n\" O\n\nIt O\n's O\na O\npart O\nof O\nthe O\npenalty O\nthat O\nI O\nhave O\nto O\naccept O\n. O\n\" O\n\nAs O\npart O\nof O\nhis O\nnew O\nbusinesslike O\napproach O\n, O\nMedvedev B-PER\nhired O\nAustralian B-MISC\ncoach O\nBob B-PER\nBrett I-PER\nat O\nthe O\nstart O\nof O\nthis O\nyear O\nand O\nthe O\npartnership O\nis O\nbeginning O\nto O\npay O\noff O\n. O\n\n\" O\nAt O\nthe O\nbeginning O\nof O\nthe O\nyear O\nwe O\nstarted O\nfrom O\nzero O\n, O\n\" O\nsaid O\nMedvedev B-PER\n. O\n\" O\n\nWinning O\nin O\nLong B-LOC\nIsland I-LOC\n( O\nlast O\nweek O\n) O\nwas O\nlike O\nwinning O\nfor O\nthe O\nfirst O\ntime O\n. O\n\" O\n\nWhile O\nMedvedev B-PER\n's O\n77-minute O\nromp O\npast O\nFleurian B-PER\nwas O\nrather O\nordinary O\n, O\nthe O\nfact O\nthat O\nthe O\ntwo O\nwere O\nplaying O\neach O\nother O\nwas O\nrather O\nremarkable O\n. O\n\nIn O\nthe O\noriginal O\ndraw O\n, O\nMedvedev B-PER\nand O\nFleurian B-PER\nwere O\nslotted O\nto O\nplay O\neach O\nother O\n. O\n\nWhen O\ncontroversy O\nforced O\nthe O\ndraw O\nto O\nbe O\ndone O\nover O\n-- O\nagainst O\nodds O\nof O\n151-to-1 O\n-- O\nMedvedev B-PER\nand O\nFleurian B-PER\ndrew O\neach O\nother O\na O\nsecond O\ntime O\n. O\n\n\" O\nWhen O\nI O\nsaw O\nthe O\nnew O\ndraw O\nI O\ndid O\nn't O\nhave O\nto O\nchange O\nmy O\npreparation O\n, O\n\" O\nMedvedev B-PER\nsaid O\n. O\n\" O\n\nI O\nthink O\nit O\n's O\ndestined O\nthat O\nit O\nturned O\nout O\nfor O\nme O\n. O\n\" O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nWEDNESDAY O\n'S O\nRESULTS O\nFROM O\nTHE O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nResults O\nof O\nWednesday O\n's O\nmatches O\nin O\nthe O\nU.S. B-MISC\nOpen I-MISC\nTennis I-MISC\nChampionships I-MISC\nat O\nthe O\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nWomen O\n's O\nsingles O\n, O\nsecond O\nround O\n\n15 O\n- O\nGabriela B-PER\nSabatini I-PER\n( O\nArgentina B-LOC\n) O\nbeat O\nAnn B-PER\nGrossman I-PER\n( O\nU.S. B-LOC\n) O\n6-2 O\n6 O\n- O\n3 O\n\nIrina B-PER\nSpirlea I-PER\n( O\nRomania B-LOC\n) O\nbeat O\nMaria B-PER\nJose I-PER\nGaidano I-PER\n( O\nArgentina B-LOC\n) O\n6-1 O\n6-2 O\n\n8 O\n- O\nLindsay B-PER\nDavenport I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nHenrietta B-PER\nNagyova I-PER\n( O\nSlovakia B-LOC\n) O\n6- O\n0 O\n6-4 O\n\nAnne-Gaelle B-PER\nSidot I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nWang B-PER\nShi-Ting I-PER\n( O\nTaiwan B-LOC\n) O\n6-4 O\n3-6 O\n6-3 O\n\nSandrine B-PER\nTestud I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nCristina B-PER\nTorrens-Valero I-PER\n( O\nSpain B-LOC\n) O\n6 O\n- O\n2 O\n6-1 O\n\nMen O\n's O\nsingles O\n, O\nfirst O\nround O\n\nAndrei B-PER\nMedvedev I-PER\n( O\nUkraine B-LOC\n) O\nbeat O\nJean-Philippe B-PER\nFleurian I-PER\n( O\nFrance B-LOC\n) O\n6-2 O\n6-0 O\n6-1 O\n\nDavid B-PER\nNainkin I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\n9 O\n- O\nWayne B-PER\nFerreira I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n6-4 O\n6-4 O\n2-6 O\n7-5 O\n\nDavid B-PER\nRikl I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nHicham B-PER\nArazi I-PER\n( O\nMorocco B-LOC\n) O\n6-4 O\n7-5 O\n6-2 O\n\nAndrea B-PER\nGaudenzi I-PER\n( O\nItaly B-LOC\n) O\nbeat O\nShuzo B-PER\nMatsuoka I-PER\n( O\nJapan B-LOC\n) O\n7-6 O\n( O\n7-4 O\n) O\n6 O\n- O\n2 O\n6-3 O\n\nMen O\n's O\nsingles O\n, O\nfirst O\nround O\n\n17 O\n- O\nFelix B-PER\nMantilla I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nFernando B-PER\nMeligeni I-PER\n( O\nBrazil B-LOC\n) O\n6-1 O\n6 O\n- O\n7 O\n( O\n2-7 O\n) O\n7-6 O\n( O\n7-5 O\n) O\n6-3 O\n\nJonas B-PER\nBjorkman I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nKarol B-PER\nKucera I-PER\n( O\nSlovakia B-LOC\n) O\n6-2 O\n5-7 O\n7- O\n6 O\n( O\n7-3 O\n) O\n7-5 O\n\nJan B-PER\nKroslak I-PER\n( O\nSlovakia B-LOC\n) O\nbeat O\nChris B-PER\nWoodruff I-PER\n( O\nU.S. B-LOC\n) O\n2-6 O\n6-4 O\n3-6 O\n6 O\n- O\n2 O\n7-6 O\n( O\n7-1 O\n) O\n\nWomen O\n's O\nsingles O\n, O\nsecond O\nround O\n\nAmanda B-PER\nCoetzer I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\nbeat O\nMariaan B-PER\nde I-PER\nSwardt I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n6-2 O\n7-5 O\n\nLinda B-PER\nWild I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nKristie B-PER\nBoogert I-PER\n( O\nNetherlands B-LOC\n) O\n5-7 O\n6-3 O\n6-3 O\n\nKimberly B-PER\nPo I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nKristina B-PER\nBrandi I-PER\n( O\nU.S. B-LOC\n) O\n6-1 O\n6-4 O\n\nHelena B-PER\nSukova I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nPaola B-PER\nSuarez I-PER\n( O\nArgentina B-LOC\n) O\n6- O\n4 O\n7-6 O\n( O\n7-2 O\n) O\n\nWomen O\n's O\nsingles O\n, O\nsecond O\nround O\n\n2 O\n- O\nMonica B-PER\nSeles I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nLaurence B-PER\nCourtois I-PER\n( O\nBelgium B-LOC\n) O\nby O\nwalkover O\n( O\nknee O\ninjury O\n) O\n\nDally B-PER\nRandriantefy I-PER\n( O\nMadagascar B-LOC\n) O\nbeat O\nJane B-PER\nChi I-PER\n( O\nU.S. B-LOC\n) O\n6-3 O\n6-1 O\n\nInes B-PER\nGorrochategui I-PER\n( O\nArgentina B-LOC\n) O\nbeat O\nAleksandra B-PER\nOlsza I-PER\n( O\nPoland B-LOC\n) O\n6 O\n- O\n1 O\n6-1 O\n\nMen O\n's O\nsingles O\n, O\nfirst O\nround O\n\n12 O\n- O\nTodd B-PER\nMartin I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nYounes B-PER\nEl I-PER\nAynaoui I-PER\n( O\nMorocco B-LOC\n) O\n6-3 O\n6-2 O\n4-6 O\n6-4 O\n\nSjeng B-PER\nSchalken I-PER\n( O\nNetherlands B-LOC\n) O\nbeat O\nGilbert B-PER\nSchaller I-PER\n( O\nAustria B-LOC\n) O\n6- O\n3 O\n6-4 O\n6-7 O\n( O\n6-8 O\n) O\n6-3 O\n\nMen O\n's O\nsingles O\n, O\nfirst O\nround O\n\nMichael B-PER\nTebbutt I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nRichey B-PER\nReneberg I-PER\n( O\nU.S. B-LOC\n) O\n3-6 O\n\n6-1 O\n3-6 O\n7-5 O\n6-3 O\n\nPaul B-PER\nHaarhuis I-PER\n( O\nNetherlands B-LOC\n) O\nbeat O\nMichael B-PER\nJoyce I-PER\n( O\nU.S B-LOC\n) O\n6-7 O\n\n( O\n5-7 O\n) O\n7-6 O\n( O\n8-6 O\n) O\n1-6 O\n6-2 O\n6-2 O\n\nWomen O\n's O\nsingles O\n, O\nsecond O\nround O\n\nBarbara B-PER\nRittner I-PER\n( O\nGermany B-LOC\n) O\nbeat O\n13 O\n- O\nBrenda B-PER\nSchultz-McCarthy I-PER\n( O\n\nNetherlands B-LOC\n) O\n6-2 O\n6-1 O\n\nMen O\n's O\nsingles O\n, O\nfirst O\nround O\n\nGuy B-PER\nForget I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nGrant B-PER\nStafford I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n3-6 O\n2-6 O\n6-4 O\n7-6 O\n( O\n7-2 O\n) O\n6-3 O\n\n( O\nEnd O\nfirst O\nround O\n) O\n\nWomen O\n's O\nsingles O\n, O\nsecond O\nround O\n\nLisa B-PER\nRaymond I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nSarah B-PER\nPitkowski I-PER\n( O\nFrance B-LOC\n) O\n6-2 O\n6-0 O\n\nAsa B-PER\nCarlsson I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nBarbara B-PER\nSchett I-PER\n( O\nAustria B-LOC\n) O\n6-2 O\n3-1 O\nretired O\n( O\nThigh O\ninjury O\n) O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nTUESDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nTuesday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n74 O\n57 O\n.565 O\n- O\n\nBALTIMORE B-ORG\n70 O\n61 O\n.534 O\n4 O\n\nBOSTON B-ORG\n68 O\n65 O\n.511 O\n7 O\n\nTORONTO B-ORG\n62 O\n71 O\n.466 O\n13 O\n\nDETROIT B-ORG\n47 O\n85 O\n.356 O\n27 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n79 O\n53 O\n.598 O\n- O\n\nCHICAGO B-ORG\n70 O\n64 O\n.522 O\n10 O\n\nMINNESOTA B-ORG\n66 O\n66 O\n.500 O\n13 O\n\nMILWAUKEE B-ORG\n64 O\n69 O\n.481 O\n15 O\n1/2 O\n\nKANSAS B-ORG\nCITY I-ORG\n60 O\n73 O\n.451 O\n19 O\n1/2 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n75 O\n57 O\n.568 O\n- O\n\nSEATTLE B-ORG\n68 O\n63 O\n.519 O\n6 O\n1/2 O\n\nOAKLAND B-ORG\n63 O\n72 O\n.467 O\n13 O\n1/2 O\n\nCALIFORNIA B-ORG\n61 O\n71 O\n.462 O\n14 O\n\nWEDNESDAY O\n, O\nAUGUST O\n28TH O\nSCHEDULE O\n\nCLEVELAND B-ORG\nAT O\nDETROIT B-LOC\n\nMILWAUKEE B-ORG\nAT O\nCHICAGO B-LOC\n\nOAKLAND B-ORG\nAT O\nBALTIMORE B-LOC\n\nMINNESOTA B-ORG\nAT O\nTORONTO B-LOC\n\nTEXAS B-ORG\nAT O\nKANSAS B-LOC\nCITY I-LOC\n\nBOSTON B-ORG\nAT O\nCALIFORNIA B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nSEATTLE B-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n81 O\n49 O\n.623 O\n- O\n\nMONTREAL B-ORG\n70 O\n60 O\n.538 O\n11 O\n\nFLORIDA B-ORG\n62 O\n70 O\n.470 O\n20 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n73 O\n.447 O\n23 O\n\nPHILADELPHIA B-ORG\n54 O\n79 O\n.406 O\n28 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nHOUSTON B-ORG\n71 O\n62 O\n.534 O\n- O\n\nST B-ORG\nLOUIS I-ORG\n69 O\n63 O\n.523 O\n1 O\n1/2 O\n\nCINCINNATI B-ORG\n65 O\n66 O\n.496 O\n5 O\n\nCHICAGO B-ORG\n64 O\n65 O\n.496 O\n5 O\n\nPITTSBURGH B-ORG\n56 O\n75 O\n.427 O\n14 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n73 O\n60 O\n.549 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n71 O\n60 O\n.542 O\n1 O\n\nCOLORADO B-ORG\n69 O\n64 O\n.519 O\n4 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n56 O\n74 O\n.431 O\n15 O\n1/2 O\n\nWEDNESDAY O\n, O\nAUGUST O\n28TH O\nSCHEDULE O\n\nCINCINNATI B-ORG\nAT O\nCOLORADO B-LOC\n\nLOS B-ORG\nANGELES I-ORG\nAT O\nMONTREAL B-LOC\n\nATLANTA B-ORG\nAT O\nPITTSBURGH B-LOC\n\nSAN B-ORG\nDIEGO I-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nCHICAGO B-ORG\nAT O\nHOUSTON B-LOC\n\nFLORIDA B-ORG\nAT O\nST B-LOC\nLOUIS I-LOC\n\nPHILADELPHIA B-ORG\nAT O\nSAN B-LOC\nFRANCISCO I-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nTUESDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\n\nBaseball O\ngames O\nplayed O\non O\nTuesday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nNational B-MISC\nLeague I-MISC\n\nPhiladelphia B-ORG\n3 O\nSAN B-ORG\nFRANCISCO I-ORG\n2 O\n\nLos B-ORG\nAngeles I-ORG\n5 O\nMONTREAL B-ORG\n1 O\n\nPITTSBURGH B-ORG\n3 O\nAtlanta B-ORG\n2 O\n\nSan B-ORG\nDiego I-ORG\n4 O\nNEW B-ORG\nYORK I-ORG\n3 O\n\nHOUSTON B-ORG\n6 O\nChicago B-ORG\n5 O\n\nFlorida B-ORG\n6 O\nST B-ORG\nLOUIS I-ORG\n3 O\n\nCincinnati B-ORG\n4 O\nCOLORADO B-ORG\n3 O\n\nAmerican B-MISC\nLeague I-MISC\n\nCleveland B-ORG\n12 O\nDETROIT B-ORG\n2 O\n\nBALTIMORE B-ORG\n3 O\nOakland B-ORG\n1 O\n\nMinnesota B-ORG\n6 O\nTORONTO B-ORG\n4 O\n\nMilwaukee B-ORG\n4 O\nCHICAGO B-ORG\n2 O\n\nKANSAS B-ORG\nCITY I-ORG\n4 O\nTexas B-ORG\n3 O\n( O\n10 O\ninnings O\n) O\n\nBoston B-ORG\n2 O\nCALIFORNIA B-ORG\n1 O\n\nSEATTLE B-ORG\n7 O\nNew B-ORG\nYork I-ORG\n4 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nGRAF B-PER\nWORKS O\nHARD O\nFOR O\nFIRST-ROUND O\nWIN O\n. O\n\nBill B-PER\nBerkrot I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-27 O\n\nIt O\nwas O\nn't O\nsupposed O\nto O\nbe O\nthis O\nhard O\nfor O\ndefending O\nchampion O\nSteffi B-PER\nGraf I-PER\nto O\nwin O\nher O\nopening O\nmatch O\nat O\nthe O\nU.S. B-MISC\nOpen I-MISC\non O\nTuesday O\nnight O\n. O\n\nBut O\nthe O\nscript O\nthat O\ncalled O\nfor O\nthe O\nusual O\nfirst-round O\ndemolition O\nby O\nthe O\ntop-ranked O\ntop O\nseed O\nwas O\nrewritten O\nby O\n29th-ranked O\nIndonesian B-MISC\nYayuk B-PER\nBasuki I-PER\nplaying O\nwith O\nnothing O\nto O\nlose O\nabandon O\n. O\n\nGraf B-PER\n, O\nof O\ncourse O\n, O\nprevailed O\n6-3 O\n7-6 O\n, O\nbut O\nnot O\nbefore O\nsome O\ntense O\nmoments O\nthat O\neven O\nhad O\nthe O\nGerman B-MISC\nsuperstar O\nthinking O\nthe O\nmatch O\nwas O\ngoing O\nthree O\nsets O\n. O\n\n\" O\nI O\nwon O\nthe O\nsecond O\nset O\n, O\nwhich O\nI O\ndid O\nn't O\nthink O\nI O\nwould O\ndo O\n, O\nbeing O\ndown O\n5-2 O\nand O\nthe O\nchances O\nshe O\nhad O\nat O\n6-5 O\n, O\n\" O\nGraf B-PER\nrecalled O\n. O\n\nSeveral O\nof O\nthe O\nother O\nwomen O\n's O\nseeds O\neased O\ninto O\nthe O\nsecond O\nround O\nwith O\nmore O\ntypical O\nGraf-like B-MISC\nefficiency O\nTuesday O\n. O\n\nAs O\nafternoon O\nturned O\nto O\nevening O\n, O\nfourth-seeded O\nSpaniard B-MISC\nConchita B-PER\nMartinez I-PER\ntook O\napart O\nRomanian B-MISC\nRuxandra B-PER\nDragomir I-PER\nin O\n58 O\nminutes O\nwith O\nthe O\nloss O\nof O\njust O\ntwo O\ngames O\n, O\none O\nmore O\nthan O\nsecond O\nseed O\nMonica B-PER\nSeles I-PER\n, O\nwho O\nopened O\nthe O\nsecond-day O\nprogramme O\nby O\ncrushing O\nAmerican B-MISC\nAnne B-PER\nMiller I-PER\n6-0 O\n6-1 O\n. O\n\nThird O\nseed O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\n, O\nthe O\n1994 O\nchampion O\n, O\nand O\neighth-seeded O\nOlympic B-MISC\ngold O\nmedalist O\nLindsay B-PER\nDavenport I-PER\ndropped O\nthree O\ngame O\neach O\nen O\nroute O\nto O\nthe O\nsecond O\nround O\n. O\n\nBut O\nthe O\nday O\nwas O\nnot O\nwithout O\nits O\nseeded O\ncasualties O\non O\nthe O\nwomen O\n's O\nside O\n. O\n\nFifth-seed O\nIva B-PER\nMajoli I-PER\nof O\nCroatia B-LOC\nwas O\npicked O\noff O\nby O\nAustrian B-MISC\nJudith B-PER\nWiesner I-PER\nand O\nWimbledon B-MISC\nsemifinalist O\nKimiko B-PER\nDate I-PER\nof O\nJapan B-LOC\n, O\nthe O\n10th O\nseed O\n, O\nfell O\n6-2 O\n7-5 O\nto O\n53rd-ranked O\nAmerican B-MISC\nKimberly B-PER\nPo I-PER\n. O\n\nDate B-PER\n's O\ndefeat O\nleft O\nno O\nother O\nseeded O\nplayers O\nin O\nSeles B-PER\n's O\nquarter O\nof O\nthe O\ndraw O\n, O\nwhich O\nlost O\nAnke B-PER\nHuber I-PER\n( O\n6 O\n) O\nand O\nMaggie B-PER\nMaleeva I-PER\n( O\n12 O\n) O\non O\nMonday O\n. O\n\nBut O\nGraf B-PER\n, O\nwinner O\nof O\n20 O\nGrand B-MISC\nSlam I-MISC\ntitles O\n, O\nwas O\nnot O\nabout O\nto O\njoin O\nthat O\nlist O\n. O\n\n\" O\nAt O\nsome O\npoints O\nI O\nfelt O\na O\nlittle O\nnervous O\n, O\n\" O\nshe O\nadmitted O\n. O\n\" O\n\nWhen O\nit O\ncame O\ndown O\nto O\nthe O\nimportant O\npoints O\n, O\nI O\nfelt O\nmore O\nconfident O\n. O\n\" O\n\nBasuki B-PER\n, O\na O\nfirst-round O\nloser O\nhere O\nfor O\nthe O\nfifth O\nconsecutive O\nyear O\n, O\nwas O\nclearly O\ngoing O\nfor O\nwinners O\n, O\nhitting O\nthe O\nlines O\nand O\nrunning O\nGraf B-PER\naround O\nthe O\ncourt O\nas O\nshe O\nbroke O\nthe O\ntop O\nseed O\ntwice O\nin O\nthe O\nsecond O\nset O\nto O\ngrab O\nthat O\nshocking O\n5-2 O\nlead O\n. O\n\nGraf B-PER\nran O\noff O\nthe O\nnext O\nthree O\ngames O\nto O\nrestore O\nsome O\nsemblance O\nof O\norder O\n. O\n\nBut O\nBasuki B-PER\n, O\nher O\nlong O\nblack O\nponytail O\nflying O\nas O\nshe O\nraced O\nfor O\nshots O\n, O\nheld O\nher O\nserve O\nand O\ntwice O\nhad O\nset O\npoint O\non O\nGraf B-PER\n's O\nserve O\nat O\n6-5 O\nbefore O\nthe O\nGerman B-MISC\nunleashed O\na O\nforehand O\npass O\nto O\nforce O\nthe O\ntie-break O\n. O\n\n\" O\nI O\nlost O\nthe O\nmoment O\n, O\n\" O\nlamented O\nBasuki B-PER\n, O\nwho O\nhas O\nreached O\nthe O\nfourth O\nround O\nat O\nWimbledon B-LOC\nfour O\ntimes O\nand O\nwas O\na O\nsemifinalist O\nin O\nMontreal B-LOC\nearlier O\nthis O\nmonth O\n. O\n\nStill O\n, O\nthe O\nfeisty O\nIndonesian B-MISC\ngot O\noff O\nto O\na O\n3-0 O\nlead O\nin O\nthe O\ntie-breaker O\nbefore O\na O\npair O\nof O\ncostly O\ndouble O\nfaults O\ngave O\nGraf B-PER\nher O\nchance O\nto O\navoid O\na O\nthird O\nset O\n. O\n\n\" O\nUsually O\nin O\nthe O\nfirst O\none O\nor O\ntwo O\nmatches O\n, O\nyou O\nwant O\nto O\nfind O\nyour O\nrhythm O\nand O\nwant O\nto O\nget O\ninto O\nit O\n, O\n\" O\nsaid O\nGraf B-PER\n, O\nwho O\nwon O\nseven O\nof O\nthe O\nlast O\neight O\npoints O\nin O\nthe O\nbreaker O\n. O\n\n\" O\nTo O\nbe O\nin O\nthat O\nsituation O\ntoday O\n, O\na O\ncouple O\nof O\ntimes O\nhaving O\nto O\nplay O\nwell O\n, O\nget O\ndown O\nand O\nplay O\npoint-by-point O\n, O\ndefinitely O\nis O\na O\ngood O\nstart O\n. O\n\" O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nSOSA B-PER\nHAS O\nSURGERY O\n, O\nOUT O\nUP O\nTO O\nSIX O\nWEEKS O\n. O\n\nCHICAGO B-LOC\n1996-08-27 O\n\nChicago B-ORG\nCubs I-ORG\nright O\nfielder O\nSammy B-PER\nSosa I-PER\nunderwent O\nsurgery O\non O\nMonday O\nto O\nremove O\na O\nfractured O\nbone O\nfrom O\nhis O\nright O\nhand O\nand O\nwill O\nmiss O\nfour O\nto O\nsix O\nweeks O\n, O\nthe O\nclub O\nannounced O\nTuesday O\n. O\n\nSosa B-PER\n, O\na O\nleading O\ncandidate O\nfor O\nNational B-MISC\nLeague I-MISC\nMost B-MISC\nValuable I-MISC\nPlayer I-MISC\nhonours O\n, O\nwas O\ninjured O\nAugust O\n20th O\nwhen O\nhe O\nwas O\nhit O\nby O\na O\nMark B-PER\nHutton I-PER\npitch O\nin O\nthe O\nfirst O\ninning O\nof O\nan O\n8-1 O\nvictory O\nover O\nthe O\nFlorida B-ORG\nMarlins I-ORG\n. O\n\nThe O\n27-year-old O\nSosa B-PER\nleads O\nthe O\nleague O\nwith O\n40 O\nhomers O\nand O\nis O\ntied O\nfor O\n10th O\nwith O\n100 O\nRBI B-MISC\n. O\n\nThe O\nloss O\nof O\nSosa B-PER\n, O\nwho O\nappeared O\nin O\nall O\n124 O\ngames O\nthis O\nseason O\n, O\nis O\na O\nhuge O\nblow O\nto O\nthe O\nCubs B-ORG\n' O\nplayoff O\nhopes O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nMARCELO B-PER\nHAT-TRICK O\nKEEPS O\nPSV B-ORG\nAT O\nTOP O\nOF O\nDUTCH B-MISC\nLEAGUE O\n. O\n\nAMSTERDAM B-LOC\n1996-08-28 O\n\nBrazilian B-MISC\nstriker O\nMarcelo B-PER\nscored O\na O\nhat-trick O\nas O\nPSV B-ORG\nEindhoven I-ORG\nmaintained O\ntheir O\n100 O\npercent O\nrecord O\nand O\nstayed O\non O\ntop O\nof O\nthe O\nDutch B-MISC\nfirst O\ndivision O\nwith O\na O\n3-1 O\nwin O\nat O\nVolendam B-LOC\non O\nWednesday O\n. O\n\nPSV B-ORG\n's O\nmain O\nrivals O\nfor O\nthe O\ntitle O\n, O\ndefending O\nchampions O\nAjax B-ORG\nAmsterdam I-ORG\n, O\ncelebrated O\nthe O\nnovelty O\nof O\nhaving O\nthe O\nroof O\nof O\ntheir O\nnew O\n51,000 O\nseat O\nstadium O\nclosed O\nagainst O\nthe O\nrain O\n, O\nwith O\na O\n1-0 O\nwin O\nover O\nAZ B-ORG\nAlkmaar I-ORG\n. O\n\nAjax B-ORG\nwere O\nmissing O\nsix O\nfirst-team O\nplayers O\nbut O\nFrank B-PER\nde I-PER\nBoer I-PER\nshot O\nhome O\nthe O\nwinner O\nfrom O\na O\n20-metre O\nfree O\nkick O\nin O\nthe O\n30th O\nminute O\nof O\na O\ndull O\ngame O\n. O\n\nMarcelo B-PER\n, O\nsigned O\nin O\nclose O\nseason O\nto O\nreplace O\ncompatriot O\nRonaldo B-PER\nwho O\nleft O\nto O\nplay O\nfor O\nBarcelona B-ORG\n, O\nopened O\nthe O\nPSV B-ORG\nscoring O\nin O\nthe O\n19th O\nminute O\nwhen O\nhe O\nfired O\nhome O\nafter O\ngood O\nwork O\nfrom O\nRene B-PER\nEijkelkamp I-PER\n. O\n\nThe O\nBrazilian B-MISC\nfound O\nthe O\nmark O\nagain O\ntwo O\nminutes O\nafter O\nhalftime O\nand O\nagain O\nin O\nthe O\n56th O\nminute O\nbefore O\nmidfielder O\nPascal B-PER\nJongsma I-PER\nscored O\na O\nconsolation O\ngoal O\nfor O\nVolendam B-ORG\nfive O\nminutes O\nfrom O\ntime O\n. O\n\nFeyenoord B-ORG\nRotterdam I-ORG\nsuffered O\nan O\nearly O\nshock O\nwhen O\nthey O\nwent O\n1-0 O\ndown O\nafter O\nfour O\nminutes O\nagainst O\nde O\nGraafschap B-ORG\nDoetinchem I-ORG\n. O\n\nThe O\nequaliser O\ncame O\nin O\nthe O\n73rd O\nminute O\nwhen O\nSwedish B-MISC\ninternational O\nHenke B-PER\nLarsson I-PER\nscored O\nfrom O\nclose O\nrange O\nand O\n10 O\nminutes O\nlater O\nJean-Paul B-PER\nvan I-PER\nGastel I-PER\ngave O\nFeyenoord B-ORG\na O\n2-1 O\nvictory O\nfrom O\nthe O\npenalty O\nspot O\n. O\n\nAfter O\nthree O\nmatches O\nPSV B-ORG\nlead O\nthe O\nfirst O\ndivision O\nwith O\nnine O\npoints O\n, O\nthree O\npoints O\nclear O\nof O\nfifth-placed O\nAjax B-ORG\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nROBSON B-PER\nWINS O\nFIRST O\nTROPHY O\nWITH O\nBARCELONA B-ORG\n. O\n\nMADRID B-LOC\n1996-08-28 O\n\nFormer O\nEngland B-LOC\nmanager O\nBobby B-PER\nRobson I-PER\nenjoyed O\nhis O\nfirst O\nsuccess O\nin O\ncharge O\nof O\nBarcelona B-ORG\nas O\nhis O\nteam O\nweathered O\n90 O\nminutes O\nof O\nnon-stop O\nAtletico B-ORG\nMadrid I-ORG\npressure O\nto O\nwin O\nthe O\nSpanish B-MISC\nSuper B-MISC\nCup I-MISC\n6-5 O\non O\naggregate O\non O\nWednesday O\n. O\n\nBarcelona B-ORG\nhad O\nwon O\nthe O\nfirst O\nleg O\n5-2 O\nbut O\nthe O\nsecond O\nleg O\nwas O\na O\ndifferent O\nstory O\n. O\n\nAtletico B-ORG\ncame O\nwithin O\na O\nwhisker O\nof O\ntaking O\nthe O\nCup B-MISC\non O\nthe O\naway-goal O\nrule O\nbut O\nsquandered O\nseveral O\nchances O\nafter O\ngoing O\n3-1 O\nahead O\n15 O\nminutes O\nfrom O\nthe O\nend O\n. O\n\nJuan B-PER\nLopez I-PER\ngave O\nAtletico B-ORG\nthe O\nlead O\nmidway O\nthrough O\nthe O\nfirst O\nhalf O\nafter O\nBarcelona B-ORG\nfullback O\nAlbert B-PER\nFerrer I-PER\nand O\nsubstitute O\ngoalkeeper O\nJulen B-PER\nLopetegui I-PER\nfailed O\nto O\nclear O\na O\nMilinko B-PER\nPantic I-PER\ncross O\n. O\n\nBarcelona B-ORG\n's O\nHristo B-PER\nStoichkov I-PER\nmade O\nhis O\nonly O\nsignificant O\ncontribution O\nof O\nthe O\nevening O\n10 O\nminutes O\nafter O\nhalftime O\nwhen O\nSergi B-PER\nBarjuan I-PER\nbroke O\ndown O\nthe O\nright O\nto O\nset O\nup O\nthe O\nfiery O\nBulgarian B-MISC\nwith O\na O\nsimple O\nequaliser O\n. O\n\nBut O\nAtletico B-ORG\nstruck O\nback O\nalmost O\nimmediately O\nthrough O\nnew O\nsigning O\nJuan B-PER\nEduardo I-PER\nEsnaider I-PER\nand O\nthen O\nSerbian B-MISC\nset-piece O\nspecialist O\nPantic B-PER\nmade O\nit O\n3-1 O\nwith O\na O\nsuperb O\nfree-kick O\nin O\nthe O\n75th O\nminute O\n. O\n\nRobson B-PER\npraised O\nAtletico B-ORG\nafter O\nthe O\ngame O\n, O\nwhich O\nwas O\nplayed O\nin O\nthe O\nCommunity B-LOC\nof I-LOC\nMadrid I-LOC\nathletic O\nstadium O\nbecause O\nof O\npitch O\nproblems O\nat O\nthe O\nVicente B-PER\nCalderon B-LOC\nground O\n. O\n\nThe O\nvenue O\nof O\nAtletico B-ORG\n's O\nfirst O\nleague O\ngame O\n, O\nscheduled O\nfor O\nSunday O\n, O\nis O\nstill O\nin O\ndoubt O\nwith O\nthe O\nReal B-ORG\nMadrid I-ORG\n's O\nSantiago B-LOC\nBernabeu I-LOC\na O\ndistinct O\npossibility O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSUMMARY O\nOF O\nSPANISH B-MISC\nSUPER B-MISC\nCUP I-MISC\n. O\n\nMADRID B-LOC\n1996-08-28 O\n\nSummary O\nof O\nthe O\nSpanish B-MISC\nSuper B-MISC\nCup I-MISC\n, O\nsecond O\nleg O\n, O\nplayed O\non O\nWednesday O\n: O\n\nAtletico B-ORG\nMadrid I-ORG\n3 O\n( O\nJuan B-PER\nLopez I-PER\n28th O\nminute O\n, O\nJuan B-PER\nEsnaider I-PER\n58th O\n, O\nMilinko B-PER\nPantic I-PER\n75th O\n) O\nBarcelona B-ORG\n1 O\n( O\nHristo B-PER\nStoichkov I-PER\n55th O\n) O\n. O\n\nHalftime O\n1-0 O\n. O\n\nAttendance O\n11,000 O\n. O\n\n( O\nBarcelona B-ORG\nwin O\n6-5 O\non O\naggregate O\n) O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBARCELONA B-ORG\nWIN O\nSPANISH B-MISC\nSUPER B-MISC\nCUP I-MISC\n. O\n\nMADRID B-LOC\n1996-08-28 O\n\nResult O\nof O\nthe O\nSpanish B-MISC\nSuper B-MISC\nCup I-MISC\n, O\nsecond O\nleg O\n, O\nplayed O\non O\nWednesday O\n: O\n\nAtletico B-ORG\nMadrid I-ORG\n3 O\nBarcelona B-ORG\n1 O\n\n( O\nBarcelona B-ORG\nwin O\n6-5 O\non O\naggregate O\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nAJAX B-ORG\nSIGN O\nARGENTINE B-MISC\nSTRIKER O\nGABRICH B-PER\n. O\n\nAMSTERDAM B-LOC\n1996-08-28 O\n\nArgentine B-MISC\nstriker O\nIwan B-PER\nCesar I-PER\nGabrich I-PER\nsigned O\na O\nfive O\nyear O\ncontract O\nwith O\nDutch B-MISC\nchampions O\nAjax B-ORG\nAmsterdam I-ORG\non O\nWednesday O\n. O\n\nThe O\n24-year-old O\nGabrich B-PER\n, O\nwho O\nsigned O\nfor O\nan O\nundisclosed O\nfee O\nfrom O\nthe O\nArgentine B-MISC\nside O\nNewell B-ORG\nOld I-ORG\nBoys I-ORG\n, O\nis O\nset O\nto O\njoin O\nDutch B-MISC\ninternational O\nPatrick B-PER\nKluivert I-PER\nin O\nthe O\nAjax B-ORG\nforward O\nline O\n. O\n\nHe O\nis O\nAjax B-ORG\n's O\nsixth O\nnew O\nsigning O\nthis O\nyear O\n, O\njoining O\nmidfielder O\nRichard B-PER\nWitschge I-PER\n, O\ndefenders O\nJohn B-PER\nVeldman I-PER\nand O\nMariano B-PER\nJuan I-PER\nand O\nstrikers O\nTijjani B-PER\nBabangida I-PER\nand O\nDani B-PER\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nPARMA B-ORG\n, O\nROMA B-ORG\nAND O\nUDINESE B-ORG\nOUT O\nOF O\nITALIAN B-MISC\nCUP I-MISC\n. O\n\nROME B-LOC\n1996-08-28 O\n\nUEFA B-MISC\nCup I-MISC\nhopefuls O\nParma B-ORG\nand O\nRoma B-ORG\n, O\nunder O\nnew O\ncoaches O\nthis O\nseason O\n, O\ncrashed O\nout O\nof O\nthe O\nItalian B-MISC\nCup I-MISC\nto O\nsecond O\ndivision O\nopponents O\non O\nWednesday O\nwhile O\nleague O\nchampions O\nMilan B-ORG\ncould O\nonly O\ndraw O\n1-1 O\nat O\nhumble O\nEmpoli B-ORG\n. O\n\nWealthy O\nParma B-ORG\n, O\nnow O\ncoached O\nby O\nthe O\nformer O\nItalian B-MISC\ninternational O\nCarlo B-PER\nAncelotti I-PER\n, O\nwere O\nwithout O\nnew O\nstriker O\nEnrico B-PER\nChiesa I-PER\nand O\nwent O\ndown O\n3-1 O\nat O\nserie O\nB O\nclub O\nPescara B-ORG\nin O\ntheir O\nsecond O\nround O\nclash O\n. O\n\nPescara B-ORG\n's O\nOttavio B-PER\nPalladini I-PER\nshattered O\nParma B-ORG\nwith O\ngoals O\nin O\nthe O\nsecond O\nand O\nfourth O\nminutes O\n. O\n\nMidfielder O\nMarco B-PER\nGiampaolo I-PER\nmade O\nit O\n3-0 O\nin O\nthe O\n38th O\nminute O\nand O\nParma B-ORG\n's O\nAlessandro B-PER\nMelli I-PER\npulled O\nback O\na O\nlate O\ngoal O\nsix O\nminutes O\nfrom O\ntime O\n. O\n\nThe O\nsecond O\nround O\nwas O\nthe O\nentry O\npoint O\nfor O\nthe O\nbulk O\nof O\nthe O\nserie B-MISC\nA I-MISC\nsides O\nwith O\nthe O\nwinners O\ngoing O\nthrough O\n. O\n\nThe O\nlater O\nstages O\nof O\nthe O\ncup O\nare O\nplayed O\nover O\ntwo O\nlegs O\n. O\n\nParma B-ORG\n's O\ndefeat O\nwas O\na O\nrepeat O\nof O\nlast O\nseason O\n's O\nfiasco O\nwhen O\nthey O\nlost O\ntheir O\nopening O\ncup O\nmatch O\n3-0 O\nto O\nPalermo B-ORG\n. O\n\nRoma B-ORG\n, O\nnow O\ncoached O\nby O\nArgentine B-MISC\nCarlos B-PER\nBianchi I-PER\nand O\nwatched O\nby O\nItalian B-MISC\nnational O\ncoach O\nArrigo B-PER\nSacchi I-PER\n, O\nlost O\n3-1 O\nto O\nCesena B-ORG\n-- O\nanother O\nrepeat O\nof O\nlast O\nseason O\nwhen O\nthe O\nRome B-LOC\nclub O\nalso O\nwent O\nout O\nat O\nthe O\nfirst O\nhurdle O\n. O\n\nUdinese B-ORG\n, O\nwith O\nGermany B-LOC\n's O\nEuro B-MISC\n' I-MISC\n96 I-MISC\nhero O\nOliver B-PER\nBierhoff I-PER\nin O\ntheir O\nlineup O\n, O\ncompleted O\nthe O\nhat-trick O\nof O\nbeaten O\nserie B-MISC\nA I-MISC\nsides O\nwhen O\nthey O\nwent O\nunder O\n2-1 O\nto O\nnewly O\nrelegated O\nCremonese B-ORG\n. O\n\nMilan B-ORG\n's O\nnew O\nUruguayan B-MISC\ncoach O\nOscar B-PER\nTabarez I-PER\navoided O\nthe O\nnightmare O\nof O\ndefeat O\nbut O\nfaces O\na O\nreplay O\nat O\nhome O\nnext O\nSunday O\n. O\n\nCup B-MISC\nholders O\nFiorentina B-ORG\neasily O\nbeat O\nCosenza B-ORG\n3-1 O\nwhile O\nEuropean B-MISC\nCup I-MISC\nholders O\nJuventus B-ORG\nalso O\ncruised O\nthrough O\nwith O\na O\n2-0 O\nwin O\nat O\nsmall O\nsouthern O\nclub O\nFidelis B-ORG\nAndria I-ORG\n. O\n\nTwo O\nother O\nserie B-MISC\nA I-MISC\nsides O\nlost O\nat O\nthe O\nweekend O\n-- O\nPiacenza B-ORG\nand O\nlast O\nyear O\n's O\nlosing O\nfinalists O\nAtalanta B-ORG\n. O\n\nTwo O\ncup O\nmatches O\ncould O\nnot O\nbe O\nplayed O\non O\nWednesday O\ndue O\nto O\nargument O\nover O\nfirst O\nround O\nresults O\n. O\n\nLecce B-ORG\n's O\n3-0 O\nweekend O\ndefeat O\nof O\nGenoa B-ORG\nwas O\nexpected O\nto O\nbe O\noverturned O\nby O\na O\nsporting O\njudge O\non O\nThursday O\nafter O\nthe O\nhome O\nclub O\nfielded O\nan O\nineligible O\nplayer O\n. O\n\nThat O\nwould O\nset O\nGenoa B-ORG\nup O\nfor O\na O\nsecond O\nround O\nmatch O\nagainst O\nlocal O\nrivals O\nSampdoria B-ORG\n. O\n\nNocerina B-ORG\n's O\n4-3 O\ndefeat O\nof O\nPiacenza B-ORG\nwas O\nalso O\nsubject O\nto O\na O\ncomplaint O\n, O\nlater O\nremoved O\n, O\nthat O\nforced O\ntheir O\nsecond O\nround O\nmatch O\nagainst O\nserie B-MISC\nA I-MISC\nnewcomers O\nPerugia B-ORG\nto O\nbe O\ndelayed O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nBAYERN B-ORG\nHIT O\nFOUR O\nTO O\nTAKE O\nBUNDESLIGA B-MISC\nTOP O\nSPOT O\n. O\n\nBONN B-LOC\n1996-08-28 O\n\nGoals O\nfrom O\nThomas B-PER\nHelmer I-PER\nand O\nJuergen B-PER\nKlinsmann I-PER\nhelped O\nBayern B-ORG\nMunich I-ORG\nto O\na O\n4-2 O\nhome O\nwin O\nover O\nBayer B-ORG\nLeverkusen I-ORG\non O\nWednesday O\nand O\npowered O\nthem O\nto O\nthe O\ntop O\nof O\nthe O\nBundesliga B-MISC\n. O\n\nThe O\ncomfortable O\nvictory O\ngave O\nBayern B-ORG\n10 O\npoints O\nfrom O\ntheir O\nfirst O\nfour O\ngames O\n, O\na O\npoint O\nahead O\nof O\nsecond-placed O\nStuttgart B-ORG\n, O\nwho O\nhave O\na O\ngame O\nin O\nhand O\n. O\n\nBrazilian B-MISC\nmidfielder O\nPaulo B-PER\nSergio I-PER\nput O\nLeverkusen B-ORG\nahead O\nin O\nthe O\n25th O\nminute O\nbut O\nAlexander B-PER\nZickler I-PER\nequalised O\njust O\na O\nminute O\nlater O\n. O\n\nA O\nheader O\nfrom O\nHelmer B-PER\nand O\nan O\nacrobatic O\nstrike O\nfrom O\nKlinsmann B-PER\ngave O\nBayern B-ORG\na O\ntwo-goal O\ncushion O\nat O\nhalftime O\n. O\n\nBut O\nthe O\npick O\nof O\nthe O\n13-times O\nchampions O\n' O\ngoals O\ncame O\nfrom O\nRuggiero B-PER\nRizzitelli I-PER\n, O\nwho O\nbeat O\nthree O\ndefenders O\nto O\nput O\nBayern B-ORG\n4-1 O\nup O\n. O\n\nMarkus B-PER\nFeldhoff I-PER\nhit O\na O\nconsolation O\ngoal O\nfor O\nLeverkusen B-ORG\n. O\n\nHansa B-ORG\nRostock I-ORG\nbrought O\nCologne B-ORG\n's O\n100 O\npercent O\nrecord O\nto O\nan O\nend O\nwith O\na O\n2-0 O\nwin O\nover O\nthe O\nRhineside B-MISC\nclub O\nwhile O\na O\nSean B-PER\nDundee I-PER\nhat-trick O\ninside O\nseven O\nminutes O\nstood O\nout O\nin O\nKarlsruhe B-ORG\n's O\n4-0 O\ndemolition O\nof O\nSt B-ORG\nPauli I-ORG\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nITALIAN B-MISC\nCUP I-MISC\nSECOND O\nROUND O\nRESULTS O\n. O\n\nROME B-LOC\n1996-08-28 O\n\nResults O\nof O\nItalian B-MISC\nCup I-MISC\nsecond O\nround O\n\nmatches O\nplayed O\non O\nWednesday O\n: O\n\nEmpoli B-ORG\n1 O\nMilan B-ORG\n1 O\n\nSpal B-ORG\n2 O\nReggiana B-ORG\n4 O\n\nLucchese B-ORG\n1 O\nVicenza B-ORG\n2 O\n\nCremonese B-ORG\n2 O\nUdinese B-ORG\n1 O\n\nCesena B-ORG\n3 O\nRoma B-ORG\n1 O\n\nBologna B-ORG\n2 O\nTorino B-ORG\n1 O\n\nCosenza B-ORG\n1 O\nFiorentina B-ORG\n3 O\n\nAvellino B-ORG\n0 O\nLazio B-ORG\n1 O\n\nBari B-ORG\n1 O\nVerona B-ORG\n1 O\n\nPescara B-ORG\n3 O\nParma B-ORG\n1 O\n\nMonza B-ORG\n0 O\nNapoli B-ORG\n1 O\n\nChievo B-ORG\n2 O\nCagliari B-ORG\n3 O\n\nRavenna B-ORG\n0 O\nInter B-ORG\n1 O\n\nFidelis B-ORG\nAndria I-ORG\n0 O\nJuventus B-ORG\n2 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nSUMMARIES O\n. O\n\nBONN B-LOC\n1996-08-28 O\n\nSummaries O\nof O\nWednesday O\n's O\nGerman B-MISC\n\nfirst O\ndivision O\nsoccer O\nmatches O\n: O\n\nKarlsruhe B-ORG\n4 O\n( O\nKeller B-PER\n18th O\nminute O\n, O\nDundee B-ORG\n56th O\n59th O\nand O\n64th O\n) O\n\nSt B-ORG\nPauli I-ORG\n0 O\n. O\n\nHalftime O\n1-0 O\n. O\n\nAttendance O\n27,600 O\n. O\n\nBayern B-ORG\nMunich I-ORG\n4 O\n( O\nZickler B-PER\n26th O\n, O\nHelmer B-PER\n37th O\n, O\nKlinsmann B-PER\n44th O\n, O\n\nRizzitelli B-PER\n48th O\n) O\nBayer B-ORG\nLeverkusen I-ORG\n2 O\n( O\nSergio B-PER\n25th O\n, O\nFeldhoff B-PER\n\n54th O\n) O\n. O\n\n3-1 O\n. O\n\n48,000 O\n. O\n\nCologne B-ORG\n0 O\nHansa B-ORG\nRostock I-ORG\n2 O\n( O\nAkpoborie B-PER\n5th O\nand O\n59th O\n) O\n. O\n\n0-1 O\n. O\n\n27,000 O\n. O\n\nFortuna B-ORG\nDuesseldorf I-ORG\n0 O\n1860 B-ORG\nMunich I-ORG\n0 O\n. O\n\n11,500 O\n. O\n\nArminia B-ORG\nBielefeld I-ORG\n1 O\n( O\nVon B-PER\nHeesen I-PER\n56th O\n) O\nDuisburg B-ORG\n1 O\n( O\nHirsch B-PER\n65th O\n) O\n. O\n\n0-0 O\n. O\n\n15,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nLEADING O\nFRENCH B-MISC\nLEAGUE O\nSCORERS O\n. O\n\nPARIS B-LOC\n1996-08-28 O\n\nLeading O\nscorers O\nin O\nthe O\nFrench B-MISC\n\nfirst O\ndivision O\nafter O\nWednesday O\n's O\nmatches O\n: O\n\n3 O\n- O\nAnton B-PER\nDrobnjak I-PER\n( O\nBastia B-ORG\n) O\n, O\nVladimir B-PER\nSmicer I-PER\n( O\nLens B-ORG\n) O\n, O\nMiladin B-PER\n\nBecanovic B-PER\n( O\nLille B-ORG\n) O\n, O\nAlain B-PER\nCaveglia I-PER\n( O\nLyon B-ORG\n) O\n, O\nXavier B-PER\nGravelaine I-PER\n\n( O\nMarseille B-ORG\n) O\n, O\nRobert B-PER\nPires I-PER\n( O\nMetz B-ORG\n) O\n, O\nThierry B-PER\nHenry I-PER\n( O\nMonaco B-ORG\n) O\n\n2 O\n- O\nChristopher B-PER\nWreh I-PER\n( O\nGuingamp B-ORG\n) O\n, O\nMarc-Vivien B-PER\nFoe I-PER\n( O\nLens B-ORG\n) O\n, O\nEnzo B-PER\n\nScifo B-PER\n( O\nMonaco B-ORG\n) O\n, O\nJames B-PER\nDebbah I-PER\n( O\nNice B-ORG\n) O\n, O\nPatrice B-PER\nLoko I-PER\n( O\nPSG B-ORG\n) O\n, O\n\nStephane B-PER\nGuivarch I-PER\n( O\nRennes B-ORG\n) O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nSMICER B-PER\n'S O\nLAST-GASP O\nGOAL O\nKEEPS O\nLENS B-ORG\nIN O\nTHE O\nLEAD O\n. O\n\nPARIS B-LOC\n1996-08-28 O\n\nEuro B-MISC\n96 I-MISC\nstar O\nVladimir B-PER\nSmicer I-PER\nof O\nthe O\nCzech B-LOC\nRepublic I-LOC\nscored O\nat O\nthe O\nlast O\nsecond O\nfor O\nLens B-ORG\n, O\nallowing O\nthem O\nto O\nretain O\nthe O\nlead O\nin O\nthe O\nFrench B-MISC\nsoccer O\nleague O\non O\nWednesday O\n. O\n\nSmicer B-PER\npushed O\nthe O\nball O\nhome O\nin O\ninjury O\ntime O\nto O\nlead O\nhis O\nteam O\nto O\na O\n3-2 O\nvictory O\nover O\nMontpellier B-ORG\n, O\nwho O\nwere O\nleading O\n2-1 O\nuntil O\nCameroon B-LOC\n's O\nMarc-Vivien B-PER\nFoe I-PER\nequalised O\non O\na O\nheader O\nin O\nthe O\n85th O\nminute O\n. O\n\nThe O\nwin O\nwas O\nthe O\nfourth O\nin O\nas O\nmany O\nmatches O\nthis O\nseason O\nfor O\nLens B-ORG\n, O\nwho O\nlead O\nthe O\ntable O\non O\n12 O\npoints O\n. O\n\nIn-form O\nParis B-ORG\nSt I-ORG\nGermain I-ORG\n, O\nwho O\ndismissed O\nNantes B-ORG\n1-0 O\n, O\nare O\nsecond O\nwith O\n10 O\npoints O\n. O\n\nAlong O\nwith O\nSmicer B-PER\n, O\nRobert B-PER\nPires I-PER\nwas O\nthe O\nstar O\nof O\nthe O\nnight O\nin O\nFrance B-LOC\n, O\nscoring O\nthe O\nfirst O\nhat-trick O\nof O\nthe O\nleague O\nseason O\nin O\nMetz B-ORG\n's O\n3-1 O\nhome O\nvictory O\nover O\nneighbouring O\nStrasbourg B-ORG\n. O\n\nPires B-PER\n, O\none O\nof O\nthe O\nmost O\npromising O\nstrikers O\nin O\nthe O\ncountry O\n, O\nwas O\ncalled O\nup O\nfor O\nthe O\nfirst O\ntime O\nthis O\nweek O\nby O\nFrench B-MISC\nmanager O\nAime B-PER\nJacquet I-PER\nfor O\na O\nfriendly O\nagainst O\nMexico B-LOC\non O\nSaturday O\nat O\nthe O\nParc B-LOC\ndes I-LOC\nPrinces I-LOC\n. O\n\nPires B-PER\nscored O\nfirst O\nwith O\na O\npowerful O\nshot O\nin O\nthe O\n35th O\nminute O\nbefore O\nstriking O\nagain O\nfrom O\nclose O\nrange O\njust O\nbefore O\nthe O\nbreak O\n. O\n\nA O\nsolitary O\nraid O\nallowed O\nhim O\nto O\nscore O\nhis O\nthird O\nin O\nthe O\n74th O\n. O\n\nSmicer B-PER\n's O\ngoal O\nwas O\nas O\nhard-won O\nas O\nhis O\nteam O\n's O\nvictory O\n. O\n\nSpurred O\nby O\nFoe B-PER\n's O\nleveller O\nfive O\nminutes O\nbefore O\n, O\nLens B-ORG\npressed O\nhard O\nand O\nFoe B-PER\nhit O\nthe O\ncrossbar O\nin O\nthe O\ndying O\nseconds O\non O\nanother O\nheader O\n. O\n\nThe O\nball O\nbounced O\nback O\nto O\nSmicer B-PER\n's O\nfeet O\nand O\nhe O\nscored O\n. O\n\nMontpellier B-ORG\nseized O\nan O\nunexpected O\nlead O\nthanks O\nto O\nKader B-PER\nFerhaoui I-PER\nin O\nthe O\nfourth O\nminute O\nafter O\na O\nblunder O\nfrom O\nLens B-ORG\ngoalkeeper O\nJean-Claude B-PER\nNadon I-PER\n. O\n\nThe O\nside O\nfrom O\nnorthern O\nFrance B-LOC\n, O\nforced O\nto O\nfight O\nan O\nuphill O\nbattle O\nfrom O\nthen O\non O\n, O\npulled O\nlevel O\nthanks O\nto O\nTony B-PER\nVairelles I-PER\nin O\nthe O\neighth O\nminute O\nbut O\nyoung O\nstriker O\nFabien B-PER\nLefevre I-PER\nmade O\nit O\ntwo O\nfor O\nMontpellier B-ORG\nfive O\nminutes O\nlater O\n. O\n\nLeague O\nfavourites O\nPSG B-ORG\nscored O\na O\nconvincing O\n1-0 O\nwin O\nover O\nNantes B-ORG\nand O\nconfirmed O\nthey O\nwould O\nagain O\nbe O\nthe O\nteam O\nto O\nbeat O\nthis O\nseason O\n. O\n\nIronically O\n, O\nPSG B-ORG\n's O\nvictory O\nowed O\na O\nlot O\nto O\ntwo O\nformer O\nNantes B-ORG\nplayers O\n, O\nstriker O\nPatrice B-PER\nLoko I-PER\n, O\nwho O\nscored O\non O\na O\nbrilliant O\nshot O\nin O\nthe O\n33rd O\nminute O\n, O\nand O\ndefender O\nBenoit B-PER\nCauet I-PER\n, O\nwho O\nstarted O\nthe O\none-two O\nwhich O\nallowed O\nLoko B-PER\nto O\nscore O\n. O\n\nThe O\nParisians B-MISC\n, O\nwho O\nhave O\nyet O\nto O\nconcede O\na O\ngoal O\n, O\nwere O\nwithout O\nBrazil B-LOC\n's O\nLeonardo B-PER\nand O\nPanama B-LOC\n's O\nJulio B-PER\nCesar I-PER\nDely I-PER\nValdes I-PER\n, O\nboth O\ncalled O\nup O\nby O\ntheir O\nnational O\nsides O\n. O\n\nFor O\nNantes B-ORG\n, O\nwho O\nshocked O\nPSG B-ORG\nto O\nwin O\nthe O\nleague O\ncrown O\ntwo O\nyears O\nago O\n, O\nthe O\nfall O\nis O\nvery O\npainful O\n. O\n\nThe B-ORG\nCanaries I-ORG\n, O\nwho O\nlost O\nmost O\nof O\ntheir O\nkey O\nplayers O\nwithin O\ntwo O\nyears O\n, O\nhave O\nyet O\nto O\nwin O\na O\nmatch O\nthis O\nseason O\n. O\n\nReigning O\nchampions O\nAuxerre B-ORG\nhad O\nto O\nsettle O\nfor O\na O\ngoalless O\ndraw O\nagainst O\nMarseille B-ORG\non O\nTuesday O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nSUMMARIES O\n. O\n\nAMSTERDAM B-LOC\n1996-08-28 O\n\nSummary O\nof O\nDutch B-MISC\nfirst O\ndivision O\n\nsoccer O\nplayed O\non O\nWednesday O\n: O\n\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n1 O\n( O\nVan B-PER\nHintum I-PER\n69th O\npenalty O\n) O\nRKC B-ORG\nWaalijk I-ORG\n2 O\n\n( O\nSchreuder B-PER\n39th O\n, O\nVan B-PER\nArum I-PER\n76th O\n, O\n83rd O\n) O\n. O\n\nHalftime O\n0-1 O\n. O\n\nAttendance O\n\n6,150 O\n. O\n\nVitesse B-ORG\nArnhem I-ORG\n1 O\n( O\nVierklau B-PER\n85th O\n) O\nSparta B-ORG\nRotterdam I-ORG\n1 O\n( O\nGerard B-PER\n\nde B-PER\nNooijer I-PER\n80th O\n) O\n. O\n\nHalftime O\n0-0 O\n. O\n\nAttendance O\n5,696 O\n. O\n\nUtrecht B-ORG\n0 O\nTwente B-ORG\nEnschede I-ORG\n0 O\n. O\n\nAttendance O\n9,000 O\n. O\n\nGroningen B-ORG\n1 O\n( O\nGorre B-PER\n66th O\n) O\nRoda B-ORG\nJC I-ORG\nKerkrade I-ORG\n1 O\n( O\nVurens B-PER\n3rd O\n) O\n\nHalftime O\n0-1 O\n. O\n\nAttendance O\n10,000 O\n. O\n\nFeyenoord B-ORG\n2 O\n( O\nLarsson B-PER\n73rd O\n, O\nVan B-PER\nGastel I-PER\n83rd O\npenalty O\n) O\nGraafschap B-ORG\n\nDoetinchem B-ORG\n1 O\n( O\nSchultz B-PER\n4th O\n) O\n. O\n\nHalftime O\n0-1 O\n. O\n\nAttendance O\n22,434 O\n. O\n\nVolendam B-ORG\n1 O\n( O\nJongsma B-PER\n85th O\n) O\nPSV B-ORG\nEindhoven I-ORG\n3 O\n( O\nMarcelo B-PER\n19th O\n, O\n47th O\n, O\n\n56rd O\n) O\n. O\n\nHalftime O\n0-1 O\n. O\n\nAttendance O\n6,000 O\n. O\n\nAjax B-ORG\nAmsterdam I-ORG\n1 O\n( O\nFrank B-PER\nde I-PER\nBoer I-PER\n30th O\n) O\nAZ B-ORG\nAlkmaar I-ORG\n0 O\n. O\n\nHalftime O\n\n1-0 O\n. O\n\nAttendance O\n48,123 O\n. O\n\nPlayed O\non O\nTuesday O\n. O\n\nFortuna B-ORG\nSittard I-ORG\n2 O\n( O\nJeffrey B-PER\n7th O\n, O\nRoest B-PER\n33rd O\n) O\nHeerenveen B-ORG\n4 O\n\n( O\nKorneev B-PER\n15th O\n, O\nHansma B-PER\n24th O\n, O\nWouden B-PER\n70th O\n, O\n90th O\n) O\n. O\n\nHalftime O\n2-2 O\n. O\n\nAttendance O\n4,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGERMAN B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nBONN B-LOC\n1996-08-28 O\n\nResults O\nof O\nGerman B-MISC\nfirst O\ndivision O\n\nsoccer O\nmatches O\non O\nWednesday O\n: O\n\nKarlsruhe B-ORG\n4 O\nSt B-ORG\nPauli I-ORG\n0 O\n\nBayern B-ORG\nMunich I-ORG\n4 O\nBayer B-ORG\nLeverkusen I-ORG\n2 O\n\nCologne B-ORG\n0 O\nHansa B-ORG\nRostock I-ORG\n2 O\n\nFortuna B-ORG\nDuesseldorf I-ORG\n0 O\n1860 B-ORG\nMunich I-ORG\n0 O\n\nArminia B-ORG\nBielefeld I-ORG\n1 O\nDuisburg B-ORG\n1 O\n\nStandings O\n( O\ntabulated O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nBayern B-ORG\nMunich I-ORG\n4 O\n3 O\n1 O\n0 O\n11 O\n4 O\n10 O\n\nVfB B-ORG\nStuttgart I-ORG\n3 O\n3 O\n0 O\n0 O\n10 O\n1 O\n9 O\n\nBorussia B-ORG\nDortmund I-ORG\n4 O\n3 O\n0 O\n1 O\n12 O\n6 O\n9 O\n\nCologne B-ORG\n4 O\n3 O\n0 O\n1 O\n7 O\n3 O\n9 O\n\nKarlsruhe B-ORG\n3 O\n2 O\n1 O\n0 O\n9 O\n3 O\n7 O\n\nBayer B-ORG\nLeverkusen I-ORG\n4 O\n2 O\n0 O\n2 O\n9 O\n8 O\n6 O\n\nVfL B-ORG\nBochum I-ORG\n4 O\n1 O\n3 O\n0 O\n4 O\n3 O\n6 O\n\nSV B-ORG\nHamburg I-ORG\n4 O\n2 O\n0 O\n2 O\n7 O\n7 O\n6 O\n\nHansa B-ORG\nRostock I-ORG\n4 O\n1 O\n2 O\n1 O\n5 O\n4 O\n5 O\n\nWerder B-ORG\nBremen I-ORG\n4 O\n1 O\n1 O\n2 O\n5 O\n6 O\n4 O\n\nMunich B-ORG\n1860 I-ORG\n4 O\n1 O\n1 O\n2 O\n3 O\n5 O\n4 O\n\nSt B-ORG\nPauli I-ORG\n4 O\n1 O\n1 O\n2 O\n7 O\n11 O\n4 O\n\nFortuna B-ORG\nDuesseldorf I-ORG\n4 O\n1 O\n1 O\n2 O\n1 O\n7 O\n4 O\n\nArminia B-ORG\nBielefeld I-ORG\n4 O\n0 O\n3 O\n1 O\n3 O\n4 O\n3 O\n\nSchalke B-ORG\n04 I-ORG\n4 O\n0 O\n3 O\n1 O\n5 O\n9 O\n3 O\n\nFreiburg B-ORG\n4 O\n1 O\n0 O\n3 O\n6 O\n13 O\n3 O\n\nBorussia B-ORG\nMoenchengladbach I-ORG\n4 O\n0 O\n2 O\n2 O\n1 O\n4 O\n2 O\n\nDuisburg B-ORG\n4 O\n0 O\n1 O\n3 O\n2 O\n9 O\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nSUMMARIES O\n. O\n\nPARIS B-LOC\n1996-08-28 O\n\nSummaries O\nof O\nFrench B-MISC\nfirst O\ndivision O\n\nmatches O\non O\nWednesday O\n: O\n\nBastia B-ORG\n0 O\nLille B-ORG\n0 O\n. O\n\n0-0 O\n. O\n\n5,000 O\n. O\n\nCannes B-ORG\n0 O\nMonaco B-ORG\n2 O\n( O\nHenry B-PER\n26th O\n, O\n71st O\n) O\n. O\n\n0-1 O\n. O\n\n7,000 O\n. O\n\nLe B-ORG\nHavre I-ORG\n1 O\n( O\nSamson B-PER\n24th O\n) O\nCaen B-ORG\n1 O\n( O\nEtienne B-PER\nMendy I-PER\n4th O\n) O\n. O\n\n1-1 O\n. O\n\n12,000 O\n. O\n\nLens B-ORG\n3 O\n( O\nVairelles B-PER\n8th O\n, O\nFoe B-PER\n85th O\n, O\nSmicer B-PER\n90th O\n) O\nMontpellier B-ORG\n2 O\n\n( O\nFerhaoui B-PER\n4th O\n, O\nLefevre B-PER\n13th O\n) O\n. O\n\n1-2 O\n. O\n\n30,000 O\n. O\n\nLyon B-ORG\n2 O\n( O\nCaveglia B-PER\n23rd O\n, O\nGiuly B-PER\n30th O\n) O\nNancy B-ORG\n0 O\n. O\n\n2-0 O\n. O\n\n15,000 O\n. O\n\nMetz B-ORG\n3 O\n( O\nPires B-PER\n35th O\n, O\n48th O\n, O\n74th O\n) O\nStrasbourg B-ORG\n1 O\n( O\nRodriguez B-PER\n56th O\n) O\n. O\n\n1-0 O\n. O\n\n14,000 O\n. O\n\nNice B-ORG\n1 O\n( O\nChaouch B-PER\n64th O\n) O\nGuingamp B-ORG\n2 O\n( O\nRouxel B-PER\n10th O\n, O\nBaret B-PER\n89th O\n) O\n. O\n\n0-1 O\n. O\n\n4,000 O\n. O\n\nParis B-ORG\nSt I-ORG\nGermain I-ORG\n1 O\n( O\nLoko B-PER\n33rd O\n) O\nNantes B-ORG\n0 O\n. O\n\n1-0 O\n. O\n\n30,000 O\n. O\n\nRennes B-ORG\n1 O\n( O\nGuivarch B-PER\n27th O\n) O\nBordeaux B-ORG\n1 O\n( O\nColleter B-PER\n86th O\n) O\n. O\n\n1-0 O\n. O\n\n16,000 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nSTANDINGS O\n. O\n\nPARIS B-LOC\n1996-08-28 O\n\nStandings O\nin O\nthe O\nFrench B-MISC\nfirst O\n\ndivision O\nafter O\nWednesday O\n's O\nmatches O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\n\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\nagainst O\n, O\npoints O\n) O\n: O\n\nLens B-ORG\n4 O\n4 O\n0 O\n0 O\n9 O\n3 O\n12 O\n\nParis B-ORG\nSaint-Germain I-ORG\n4 O\n3 O\n1 O\n0 O\n4 O\n0 O\n10 O\n\nBastia B-ORG\n4 O\n2 O\n2 O\n0 O\n4 O\n1 O\n8 O\n\nAuxerre B-ORG\n4 O\n2 O\n2 O\n0 O\n3 O\n0 O\n8 O\n\nMonaco B-ORG\n4 O\n2 O\n1 O\n1 O\n7 O\n4 O\n7 O\n\nLyon B-ORG\n4 O\n2 O\n1 O\n1 O\n6 O\n4 O\n7 O\n\nMetz B-ORG\n4 O\n2 O\n1 O\n1 O\n6 O\n4 O\n7 O\n\nLille B-ORG\n4 O\n2 O\n1 O\n1 O\n4 O\n3 O\n7 O\n\nGuingamp B-ORG\n4 O\n2 O\n1 O\n1 O\n4 O\n3 O\n7 O\n\nCannes B-ORG\n4 O\n2 O\n1 O\n1 O\n4 O\n4 O\n7 O\n\nBordeaux B-ORG\n4 O\n1 O\n3 O\n0 O\n3 O\n2 O\n6 O\n\nMarseille B-ORG\n4 O\n1 O\n2 O\n1 O\n5 O\n4 O\n5 O\n\nRennes B-ORG\n4 O\n1 O\n1 O\n2 O\n5 O\n7 O\n4 O\n\nStrasbourg B-ORG\n4 O\n1 O\n0 O\n3 O\n2 O\n7 O\n3 O\n\nMontpellier B-ORG\n4 O\n0 O\n2 O\n2 O\n3 O\n5 O\n2 O\n\nLe B-ORG\nHavre I-ORG\n4 O\n0 O\n2 O\n2 O\n2 O\n4 O\n2 O\n\nCaen B-ORG\n4 O\n0 O\n2 O\n2 O\n2 O\n6 O\n2 O\n\nNice B-ORG\n4 O\n0 O\n1 O\n3 O\n3 O\n7 O\n1 O\n\nNantes B-ORG\n4 O\n0 O\n1 O\n3 O\n2 O\n6 O\n1 O\n\nNancy B-ORG\n4 O\n0 O\n1 O\n3 O\n2 O\n7 O\n1 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nLEAGUE O\nRESULTS O\n. O\n\nPARIS B-LOC\n1996-08-28 O\n\nFrench B-MISC\nfirst O\ndivision O\nsoccer O\n\nmatches O\non O\nWednesday O\n: O\n\nParis B-ORG\nSG I-ORG\n1 O\nNantes B-ORG\n0 O\n\nLens B-ORG\n3 O\nMontpellier B-ORG\n2 O\n\nBastia B-ORG\n0 O\nLille B-ORG\n0 O\n\nCannes B-ORG\n0 O\nMonaco B-ORG\n2 O\n\nRennes B-ORG\n1 O\nBordeaux B-ORG\n1 O\n\nLyon B-ORG\n2 O\nNancy B-ORG\n0 O\n\nNice B-ORG\n1 O\nGuingamp B-ORG\n2 O\n\nMetz B-ORG\n3 O\nStrasbourg B-ORG\n1 O\n\nLe B-ORG\nHavre I-ORG\n1 O\nCaen B-ORG\n1 O\n\nPlayed O\nTuesday O\n: O\n\nAuxerre B-ORG\n0 O\nMarseille B-ORG\n0 O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nCHRISTIE B-PER\nAND O\nJOHNSON B-PER\nASKED O\nTO O\nJOIN O\nOWENS B-PER\n' O\nTRIBUTE O\n. O\n\nAdrian B-PER\nWarner I-PER\n\nBONN B-LOC\n1996-08-28 O\n\nOrganisers O\nhope O\nto O\npersuade O\nBritain B-LOC\n's O\nformer O\nOlympic B-MISC\n100 O\nmetres O\nchampion O\nLinford B-PER\nChristie I-PER\nto O\njoin O\na O\n\" O\nDream B-ORG\nTeam I-ORG\n\" O\nsprint O\nrelay O\nin O\na O\nspecial O\ntribute O\nto O\nJesse B-PER\nOwens I-PER\nat O\nFriday O\n's O\nBerlin B-LOC\ngrand O\nprix O\n. O\n\nChristie B-PER\n, O\nwho O\nis O\nretiring O\nfrom O\ninternational O\ncompetition O\nat O\nthe O\nend O\nof O\nthe O\nseason O\n, O\nwas O\nnot O\ndue O\nto O\ncompete O\nin O\nthe O\nGerman B-MISC\ncapital O\nbut O\nBerlin B-LOC\npromoter O\nRudi B-PER\nThiel I-PER\nsaid O\n: O\n\" O\nWe O\nare O\nstill O\nhopeful O\nof O\ngetting O\nhim O\nto O\ncome O\n. O\n\" O\n\nThiel B-PER\nhas O\nmanaged O\nto O\nget O\nmost O\nof O\nthe O\nOlympic B-MISC\n100 O\nmetres O\nchampions O\nsince O\n1948 O\nto O\nattend O\nthe O\nmeeting O\n, O\nwhich O\nis O\nbeing O\nheld O\nin O\nthe O\nstadium O\nwhere O\nOwens B-PER\nwon O\nfour O\ngold O\nmedals O\n60 O\nyears O\nago O\nat O\nthe O\nBerlin B-LOC\nOlympics B-MISC\n. O\n\nCanada B-LOC\n's O\nDonovan B-PER\nBailey I-PER\n, O\nthe O\nOlympic B-MISC\n100 O\nmetres O\nchampion O\nand O\nworld O\nrecord O\nholder O\n, O\nand O\nNamibian O\nFrankie B-PER\nFredericks I-PER\n, O\nthe O\nsilver O\nmedallist O\nat O\nthe O\nrecent O\nAtlanta B-LOC\nGames B-MISC\n, O\nhave O\nalready O\nagreed O\nto O\nrun O\nin O\nthe O\n4X100 O\nmetres O\nteam O\n. O\n\nThiel B-PER\nsaid O\non O\nWednesday O\nthat O\nhe O\nhad O\nalso O\nasked O\nOlympic B-MISC\n200 O\nand O\n400 O\nchampion O\nMichael B-PER\nJohnson I-PER\nto O\nrun O\nas O\nwell O\nas O\nChristie B-PER\n. O\n\n\" O\nMost O\nof O\nthe O\nOlympic B-MISC\nchampions O\nof O\nthe O\npast O\nare O\ncoming O\nincluding O\nBritain B-LOC\n's O\n( O\n1980 O\nchampion O\n) O\nAllan B-PER\nWells I-PER\n. O\n\nChristie B-PER\nbelongs O\nto O\nthem O\n. O\n\nIt O\nwould O\nbe O\ngreat O\nto O\nhave O\nhim O\nhere O\n. O\n\n\" O\nThere O\nis O\na O\ngood O\noffer O\n.... O\n\nMy O\nminimum O\nwould O\nbe O\nthat O\nhe O\njust O\nran O\nthe O\nrelay O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\n36-year-old O\nBriton B-MISC\nis O\nstill O\nconsidering O\nthe O\noffer O\nand O\nis O\nexpected O\nto O\nannounce O\nhis O\ndecision O\nlater O\non O\nWednesday O\n. O\n\nOwens B-PER\n's O\nwidow O\nRuth B-PER\nis O\nnot O\nwell O\nenough O\nto O\nattend O\nbut O\na O\nmessage O\nfrom O\nher O\nwill O\nbe O\nread O\nout O\nduring O\nthe O\nmeeting O\nand O\none O\nof O\nthe O\nsprinter O\n's O\nrelatives O\nis O\nexpected O\nto O\nattend O\n. O\n\nThe O\nrelay O\nrace O\n, O\nwhich O\nwill O\ninclude O\nsquads O\nfrom O\nAfrica B-LOC\n, O\nthe O\nUnited B-LOC\nStates I-LOC\nand O\nEurope B-LOC\nas O\nwell O\nas O\nthe O\nOwens B-PER\n' O\nquartet O\n, O\nwill O\nbe O\nheld O\nat O\nthe O\nend O\nof O\nthe O\nmeeting O\n. O\n\nOrganisers O\nhad O\nhoped O\nto O\ninclude O\n1984 O\nand O\n1988 O\nchampion O\nCarl B-PER\nLewis I-PER\nin O\nthe O\nsquad O\nbut O\nhe O\ninjured O\nhimself O\nin O\nBrussels B-LOC\nlast O\nFriday O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nNEW O\nCAPTAIN O\nTENDULKAR B-PER\nUPSTAGED O\nBY O\n120 O\nFROM O\nJAYASURIYA B-PER\n. O\n\nCOLOMBO B-LOC\n1996-08-28 O\n\nSachin B-PER\nTendulkar I-PER\nmarked O\nhis O\ndebut O\nas O\nIndian B-MISC\ncaptain O\nwith O\na O\npatient O\n110 O\non O\nWednesday O\n, O\nbut O\nwas O\nupstaged O\nby O\ndashing O\nSri B-MISC\nLankan I-MISC\nopener O\nSanath B-PER\nJayasuriya I-PER\nwhose O\n120 O\nsteered O\nthe O\nworld O\nchampions O\nto O\na O\nnine-wicket O\nSinger B-MISC\nCup I-MISC\nwin O\n. O\n\nSri B-LOC\nLanka I-LOC\n, O\nplaying O\nin O\nfront O\nof O\ntheir O\nhome O\ncrowd O\nfor O\nthe O\nfirst O\ntime O\nsince O\nwinning O\nthe O\nWorld B-MISC\nCup I-MISC\nlast O\nMarch O\n, O\ncomfortably O\npassed O\nIndia B-LOC\n's O\nmodest O\n226-5 O\nfrom O\n50 O\novers O\nin O\n44.2 O\novers O\n. O\n\nThe O\ndevastating O\nopening O\npair O\nof O\nJayasuriya B-PER\nand O\nRomesh B-PER\nKaluwitharana I-PER\nshared O\na O\nfine O\nfirst O\nwicket O\nstand O\nof O\n129 O\nto O\nthe O\ndelight O\nof O\nthe O\n25,000 O\nfans O\n. O\n\nJayasuriya B-PER\n, O\nwhose O\nfirst O\n50 O\nincluded O\nthree O\nsixes O\nand O\nthree O\nfours O\n, O\nwent O\non O\nto O\nan O\nunbeaten O\n120 O\nand O\nthe O\nman-of-the-match O\naward O\n. O\n\nKaluwitharana B-PER\n, O\nslow O\nin O\ncomparison O\n, O\nwas O\nbowled O\nby O\nTendulkar B-PER\nfor O\n53 O\n, O\nbut O\nAravinda B-PER\nde I-PER\nSilva I-PER\nwith O\n49 O\nnot O\nout O\nhelped O\nsee O\nSri B-LOC\nLanka I-LOC\nhome O\n. O\n\nEarlier O\n, O\nTendulkar B-PER\ncompleted O\nhis O\nninth O\ncentury O\nin O\none-day O\ncricket O\n, O\ntaking O\n138 O\nballs O\nto O\ndo O\nit O\nbefore O\nbeing O\nrun O\nout O\n. O\n\nThe O\nrest O\nof O\nthe O\nIndian B-MISC\nbatting O\nwas O\ngenerally O\ntied O\ndown O\nby O\nbrilliant O\nfielding O\nand O\nsome O\nfairly O\ntight O\nbowling O\n, O\nalthough O\nex-captain O\nMohamed B-PER\nAzharuddin I-PER\nchipped O\nin O\nwith O\n58 O\n, O\nadding O\n129 O\nwith O\nTendulkar B-PER\noff O\n28 O\novers O\n, O\nbefore O\nbeing O\nstumped O\n. O\n\nThe O\nnext O\nmatch O\nin O\nthe O\nfour-nation O\ntournament O\nis O\non O\nFriday O\nwhen O\nSri B-LOC\nLanka I-LOC\nplay O\nAustralia B-LOC\nin O\na O\nrepeat O\nof O\nthe O\nWorld B-MISC\nCup I-MISC\nfinal O\nin O\nLahore B-LOC\nwhere O\nSri B-LOC\nLanka I-LOC\nwon O\nby O\nseven O\nwickets O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nSRI B-LOC\nLANKA I-LOC\nBEAT O\nINDIA B-LOC\nBY O\n9 O\nWICKETS O\nIN O\nONE-DAY O\nMATCH O\n. O\n\nCOLOMBO B-LOC\n1996-08-28 O\n\nSri B-LOC\nLanka I-LOC\nbeat O\nIndia B-LOC\nby O\nnine O\nwickets O\nin O\nthe O\nsecond O\nmatch O\nof O\nthe O\nSinger B-MISC\nWorld I-MISC\nSeries I-MISC\none-day O\n( O\n50 O\novers O\n) O\ncricket O\ntournament O\non O\nMonday O\n. O\n\nScores O\n: O\nIndia B-LOC\n226-5 O\nin O\n50 O\novers O\n, O\nSri B-LOC\nLanka I-LOC\n230-1 O\nin O\n44.2 O\novers O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nINDIA B-LOC\nV O\nSRI B-LOC\nLANKA I-LOC\nSCOREBOARD O\n. O\n\nCOLOMBO B-LOC\n1996-08-28 O\n\nScoreboard O\nof O\nthe O\nsecond O\nSinger B-MISC\n\nWorld B-MISC\nSeries I-MISC\ncricket O\nmatch O\nbetween O\nIndia B-LOC\nand O\nSri B-LOC\nLanka I-LOC\non O\n\nWednesday O\n: O\n\nIndia B-LOC\n\nA. B-PER\nJadeja I-PER\nrun O\nout O\n0 O\n\nS. B-PER\nTendulkar I-PER\nrun O\nout O\n110 O\n\nS. B-PER\nGanguly I-PER\nc O\nde B-PER\nSilva I-PER\nb O\nDharmasena B-PER\n16 O\n\nM. B-PER\nAzharuddin I-PER\nst O\nKaluwitharana B-PER\nb O\nJayasuriya B-PER\n58 O\n\nV. B-PER\nKambli I-PER\nrun O\nout O\n18 O\n\nR. B-PER\nDravid I-PER\nnot O\nout O\n7 O\n\nJ. B-PER\nSrinath I-PER\nnot O\nout O\n1 O\n\nExtras O\n( O\nb-1 O\nlb-3 O\nw-9 O\nnb-3 O\n) O\n16 O\n\nTotal O\n( O\n5 O\nwickets O\n, O\n50 O\novers O\n) O\n226 O\n\nFall O\nof O\nwickets O\n: O\n1-4 O\n2-57 O\n3-186 O\n4-217 O\n5-217 O\n. O\n\nDid O\nnot O\nbat O\n: O\nA. B-PER\nKumble I-PER\n, O\nN. B-PER\nMongia I-PER\n, O\nV. B-PER\nPrasad I-PER\n, O\nA. B-PER\nKapoor I-PER\n. O\n\nBowling O\n: O\nVass B-PER\n9-2-35-0 O\n, O\nPushpakumara B-PER\n6-0-23-0 O\n, O\nDharmasena B-PER\n\n10-0-59-1 O\nMuralitharan B-PER\n10-0-42-0 O\n, O\nJayasuriya B-PER\n10-1-39-1 O\n, O\nde B-PER\nSilva I-PER\n\n5-0-24-0 O\n. O\n\nSri B-LOC\nLanka I-LOC\n\nS. B-PER\nJayasuriya I-PER\nnot O\nout O\n120 O\n\nR. B-PER\nKaluwitharana I-PER\nb O\nTendulkar B-PER\n53 O\n\nA.de B-PER\nSilva I-PER\nnot O\nout O\n49 O\n\nExtras O\n( O\nlb-3 O\nnb-3 O\nw-2 O\n) O\n8 O\n\nTotal O\n( O\nfor O\none O\nwicket O\n- O\n44.2 O\novers O\n) O\n230 O\n\nFall O\nof O\nwicket O\n: O\n1-129 O\n\nDid O\nnot O\nbat O\n: O\nArjuna B-PER\nRanatunga I-PER\n, O\nAsanka B-PER\nGurusinha I-PER\n, O\nHashan B-PER\n\nTillekeratne B-PER\n, O\nRoshan B-PER\nMahanama I-PER\n, O\nKumara B-PER\nDharmasena I-PER\n, O\nChaminda B-PER\nVaas I-PER\n, O\n\nMuthiah B-PER\nMuralitharan I-PER\n, O\nRavindra B-PER\nPushpakumara I-PER\n\nBowling O\n: O\nKumble B-PER\n10-1-40-0 O\n, O\nPrasad B-PER\n6-0-47-0 O\n, O\nSrinath B-PER\n\n8-0-33-0 O\n, O\nTendulkar B-PER\n6-0-29-1 O\n, O\nKapoor B-PER\n10-2-51-0 O\n, O\nJadeja B-PER\n\n2.2-0-13-0 O\n, O\nGanguly B-PER\n2-0-14-0 O\n\nResult O\n: O\nSri B-LOC\nLanka I-LOC\nwon O\nby O\n9 O\nwickets O\n\nMan-of-the-Match O\n: O\nSanath B-PER\nJayasuriya I-PER\n\n-DOCSTART- O\n\nCRICKET O\n- O\nINDIA B-LOC\nWIN O\nTOSS O\nAND O\nBAT O\nAGAINST O\nSRI B-LOC\nLANKA I-LOC\n. O\n\nCOLOMBO B-LOC\n1996-08-28 O\n\nIndia B-LOC\nwon O\nthe O\ntoss O\nand O\nelected O\nto O\nbat O\nagainst O\nSri B-LOC\nLanka I-LOC\nin O\nthe O\nsecond O\nday-night O\nlimited O\novers O\ncricket O\nmatch O\nof O\nthe O\nSinger B-MISC\nWorld I-MISC\nSeries I-MISC\ntournament O\non O\nWednesday O\n. O\n\nTeams O\n: O\n\nIndia B-LOC\n- O\nSachin B-PER\nTendulkar I-PER\n( O\ncaptain O\n) O\n, O\nAnil B-PER\nKumble I-PER\n, O\nAjay B-PER\nJadeja I-PER\n, O\nSourav B-PER\nGanguly I-PER\n, O\nMohamed B-PER\nAzharuddin I-PER\n, O\nVinod B-PER\nKambli I-PER\n, O\nRahul B-PER\nDravid I-PER\n, O\nNayan B-PER\nMongia I-PER\n, O\nJavagal B-PER\nSrinath I-PER\n, O\nVenkatesh B-PER\nPrasad I-PER\n, O\nAshish B-PER\nKapoor I-PER\n. O\n\nSri B-LOC\nLanka I-LOC\n- O\nArjuna B-PER\nRanatunga I-PER\n( O\ncaptain O\n) O\n, O\nSanath B-PER\nJayasuriya I-PER\n, O\nRomesh B-PER\nKaluwitharana I-PER\n, O\nAsanka B-PER\nGurusinha I-PER\n, O\nAravinda B-PER\nde I-PER\nSilva I-PER\n, O\nHashan B-PER\nTillekeratne I-PER\n, O\nRoshan B-PER\nMahanama I-PER\n, O\nKumara B-PER\nDharmasena I-PER\n, O\nChaminda B-PER\nVaas I-PER\n, O\nMuthiah B-PER\nMuralitharan I-PER\n, O\nRavindra B-PER\nPushpakumara I-PER\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nANGOLA B-LOC\n- O\nAUG O\n28 O\n. O\n\nLUANDA B-LOC\n1996-08-28 O\n\nThese O\nare O\nthe O\nleading O\nstories O\nin O\nthe O\nAngolan B-MISC\npress O\non O\nWednesday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nJORNAL B-ORG\nDE I-ORG\nANGOLA I-ORG\n\n- O\nPrinceton B-PER\nLyman I-PER\n, O\nthe O\nU.S. B-LOC\nUnder-Secretary O\nof O\nState O\nfor O\nInternational O\nOrganisations O\n, O\nwill O\non O\nWednesday O\ncontinue O\nhis O\nwork O\nin O\nAngola B-LOC\nvisiting O\nBailundo B-LOC\n, O\nwhere O\nhe O\nshould O\nbe O\nreceived O\nby O\nJonas B-PER\nSavimbi I-PER\n, O\nleader O\nof O\nUnita B-ORG\n. O\n\nOn O\nTuesday O\nLyman B-PER\nparticipated O\nin O\na O\nmeeting O\nof O\na O\njoint-commission O\nwhere O\nhe O\nconsidered O\nthat O\nthe O\nAngolan B-MISC\npoliticians O\nshould O\nadvance O\nfaster O\nand O\nfind O\na O\nway O\nto O\ncooperate O\n. O\n\nIn O\nhis O\nopinion O\nthe O\nquartering O\nof O\nUnita B-ORG\nforces O\nmust O\nbe O\nconcluded O\nin O\nall O\nthe O\nAngolan B-MISC\nterritory O\nand O\nthe O\ntroops O\nmust O\nbe O\nselected O\nand O\nintegrated O\nin O\nthe O\narmed O\nforces O\n, O\nthe O\ngovernment O\nforces O\nmust O\nbe O\nconcentrated O\nin O\nthe O\nprincipal O\nunits O\nand O\nthe O\nfree O\ncirculation O\nof O\npeople O\nand O\ngoods O\nmust O\nbe O\nreality O\nin O\nall O\nthe O\ncountry O\n. O\n\n-DOCSTART- O\n\nS.AFRICAN B-MISC\nTRUTH O\nBODY O\nTO O\nSUMMON O\nAPARTHEID O\nPOLICE O\n. O\n\nCAPE B-LOC\nTOWN I-LOC\n1996-08-28 O\n\nSouth B-LOC\nAfrica I-LOC\n's O\nTruth B-ORG\nand I-ORG\nReconciliation I-ORG\nCommission I-ORG\nsaid O\non O\nWednesday O\nit O\nwould O\nsubpoena O\npersons O\naccused O\nof O\nhuman O\nrights O\nviolations O\nto O\nappear O\nbefore O\nit O\n. O\n\n\" O\nWe O\ncan O\nsubpoena O\nanyone O\nwe O\nwant O\nto O\n, O\neven O\nthe O\npresident O\nof O\nthe O\ncountry O\n, O\n\" O\nspokesman O\nJohn B-PER\nAllen I-PER\ntold O\nReuters B-ORG\n. O\n\" O\n\nSubpoenas O\nare O\ndue O\nto O\nbe O\nserved O\non O\na O\nnumber O\nof O\npeople O\nthis O\nweek O\n. O\n\" O\n\nMedia O\nreports O\nhave O\nspeculated O\nthat O\nthe O\ncommission O\n, O\nwhich O\nis O\ntrying O\nto O\nheal O\nthe O\nwounds O\nof O\napartheid O\nby O\nconfronting O\nthe O\npast O\n, O\ncould O\nsubpoena O\napartheid-era O\nPresident O\nP.W. B-PER\nBotha I-PER\nand O\nformer O\npolice O\ngenerals O\nBasie B-PER\nSmit I-PER\nand O\nJohan B-PER\nVan I-PER\nDer I-PER\nMerwe I-PER\n. O\n\nIn O\nsubmissions O\nlast O\nweek O\nto O\nthe O\ncommission O\nNational B-ORG\nParty I-ORG\nleader O\nand O\nformer O\npresident O\nF.W. B-PER\nDe I-PER\nKlerk I-PER\nsaid O\nhe O\nhad O\nreceived O\nno O\nco-operation O\nfrom O\nBotha B-PER\nin O\ncompiling O\nhis O\nparty O\n's O\nreport O\n. O\n\nSince O\nit O\nbegan O\nwork O\nin O\nApril O\nthe O\ncommission O\nhas O\nbeen O\nhearing O\nharrowing O\ntales O\nfrom O\nthe O\nvictims O\nof O\napartheid-era O\nabuses O\n, O\nby O\nboth O\nthe O\nwhite O\nminority O\nregime O\nand O\nits O\nopponents O\n. O\n\nIt O\nalso O\nwants O\nto O\nhear O\nfrom O\nthose O\nwho O\ncommitted O\nthe O\nabuses O\n, O\nto O\nwhom O\nit O\ncan O\noffer O\namnesty O\nin O\nreturn O\nfor O\nfrankness O\n. O\n\nHopes O\nthat O\nreformed O\nperpetrators O\nwould O\ncome O\nforward O\nvoluntarily O\nhave O\nfaded O\nbut O\nthe O\ncommission O\nhas O\nthe O\nlegal O\npower O\nto O\nforce O\nthem O\nto O\nappear O\n. O\n\nAllen B-PER\ndeclined O\nto O\ngive O\nsay O\nwho O\nwould O\nbe O\nsubpoenaed O\n. O\n\n\" O\nAt O\nthe O\nmoment O\nwe O\nhave O\na O\npreliminary O\nlist O\nof O\nless O\nthan O\n10 O\npeople O\n, O\nbut O\nthis O\nis O\njust O\nthe O\nbeginning O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\ncommission O\nwas O\nset O\nup O\nlast O\nyear O\nto O\nprobe O\n30 O\nyears O\nof O\nhuman-rights O\nviolations O\nduring O\nthe O\napartheid O\nera O\n. O\n\nIt O\nis O\nchaired O\nby O\nNobel B-MISC\nPeace I-MISC\nwinner O\n, O\nretired O\nArchbishop O\nDesmond B-PER\nTutu I-PER\n. O\n\nAllen B-PER\nsaid O\nthe O\ncommission O\ncould O\nannounce O\nthe O\nnames O\nof O\nsubpoenaed O\npersons O\non O\nMonday O\nnext O\nweek O\n. O\n\n-DOCSTART- O\n\nTURKISH B-MISC\nAIRPLANE O\nLANDS O\nIN O\nSOFIA B-LOC\nON O\nBOMB O\nTHREAT O\n. O\n\nSOFIA B-LOC\n1996-08-28 O\n\nA O\nTurkish B-MISC\nairliner O\non O\nflight O\nfrom O\nIstanbul B-LOC\nto O\nVienna B-LOC\non O\nWednesday O\nlanded O\nin O\nemergency O\nat O\nSofia B-LOC\nairport O\nafter O\nreceiving O\na O\nbomb O\nthreat O\n, O\nsaid O\nan O\nairport O\nofficial O\n. O\n\n\" O\nThe O\nplane O\nlanded O\nat O\nSofia B-LOC\nairport O\nat O\n1503 O\n( O\n1203 O\nGMT B-MISC\n) O\nafter O\nreceiving O\na O\nsignal O\nthat O\nthere O\nis O\nan O\nexplosive O\non O\nboard O\n, O\n\" O\nthe O\nofficial O\n, O\nwho O\ndeclined O\nto O\nbe O\nnamed O\ntold O\nReuters B-ORG\n. O\n\nThe O\nplane O\n, O\nsurrounded O\nby O\n11 O\nfire-engines O\n, O\nis O\nbeing O\nchecked O\nfor O\nexplosives O\nat O\nthe O\nmoment O\n. O\n\nNothing O\nhas O\nbeen O\nfound O\nso O\nfar O\n, O\nadded O\nthe O\nofficial O\n. O\n\nIn O\nMarch O\na O\nTurkish B-MISC\nCypriot I-MISC\nairliner O\nhijacked O\nwhile O\non O\na O\nflight O\nfrom O\nnorthern O\nCyprus B-LOC\nto O\nIstanbul B-LOC\nlanded O\nin O\nSofia B-LOC\nairport O\nto O\nrefuel O\nbefore O\nlanding O\nin O\nMunich B-LOC\n, O\nwhere O\nthe O\nhijacker O\nwas O\narrested O\n. O\n\n-DOCSTART- O\n\nArch B-ORG\nAlberta B-LOC\nwell O\ntests O\n1,100 O\nbbl O\n/ O\nday O\n. O\n\nFORT B-LOC\nWORTH I-LOC\n, O\nTexas B-LOC\n1996-08-28 O\n\nArch B-ORG\nPetroleum I-ORG\nInc I-ORG\nsaid O\nWednesday O\nan O\nexploratory O\nwell O\nin O\nAlberta B-LOC\n's O\nMorinville B-LOC\narea O\ntested O\nin O\nexcess O\nof O\n1,100 O\nbarrels O\ndaily O\nand O\nwill O\nbegin O\nproduction O\nimmediately O\n. O\n\nThe O\ncompany O\nsaid O\nthe O\n90 O\npercent O\nowned O\nTrax B-MISC\net I-MISC\nal I-MISC\nMorinville I-MISC\n10-23 I-MISC\nlogged O\n28 O\nfeet O\nof O\nproductive O\nLeduc B-LOC\nReef I-LOC\nat O\n5,350 O\nfeet O\n. O\n\nReserve O\nestimates O\nfrom O\nthis O\nwell O\nare O\nat O\n250,000 O\ngross O\nbarrels O\nof O\noil O\n. O\n\nThe O\nTrax B-LOC\nwell O\nis O\none O\nof O\nthe O\nprospects O\ndeveloped O\nby O\nArch B-ORG\nthrough O\nits O\nearly O\n1996 O\npurchase O\nof O\nTrax B-ORG\nPetroleums I-ORG\nLtd I-ORG\n, O\nthe O\ncompany O\nsaid O\n. O\n\nIt O\nsaid O\nanother O\n, O\nthe O\nCometra B-MISC\net I-MISC\nal I-MISC\nMorinville I-MISC\n11-13 I-MISC\n, O\nhas O\nlogged O\n128 O\nfeet O\nof O\nproductive O\nLeduc B-LOC\nReef I-LOC\nat O\n5,400 O\nfeet O\nand O\nis O\nflowing O\nwater O\nfree O\nat O\nthe O\nrate O\nof O\n590 O\nbarrels O\nof O\noil O\nper O\nday O\non O\na O\n15 O\n/ O\n64ths-inch O\nchoke O\n. O\n\nArch B-ORG\nowns O\na O\n16 O\npercent O\nworking O\ninterest O\nin O\nthis O\nwell O\nwith O\nmost O\nof O\nthe O\nrest O\nheld O\nby O\nthe O\nprivately O\nowned O\noperator O\n. O\n\nArch B-ORG\nsaid O\nfull O\nproduction O\nhas O\nbegun O\nand O\ninitial O\nestimates O\nof O\ngross O\nreserves O\nattributable O\nto O\nthis O\nwell O\nrange O\nup O\nto O\none O\nmillion O\nbarrels O\nof O\noil O\n. O\n\nA O\nthird O\nwell O\ndrilled O\nin O\nthis O\narea O\n, O\nthe O\nTrax B-MISC\net I-MISC\nal I-MISC\nMorinville I-MISC\n2-25 I-MISC\n, O\nencountered O\nthe O\nLeduc B-LOC\nReef I-LOC\nbut O\ntested O\nwet O\n. O\n\nAt O\nthe O\ncompany O\n's O\nNordegg B-MISC\nprospect O\n, O\nthe O\nApache B-MISC\net I-MISC\nal I-MISC\nSaunders I-MISC\n14-28 I-MISC\n, O\nhas O\nreached O\ntotal O\ndepth O\nin O\nthe O\nLeduc B-LOC\nReef I-LOC\nat O\napproximately O\n3,800 O\nfeet O\nand O\nhas O\nbeen O\nabandoned O\n, O\nArch B-ORG\nsaid O\n. O\n\nIt O\nsaid O\nthis O\nacreage O\nearning O\nwell O\nbrought O\nan O\ninterest O\nin O\nan O\nadditional O\n5,120 O\nacres O\n, O\nbuilding O\nthe O\ncompany O\n's O\ngross O\nland O\nposition O\nin O\nthis O\narea O\nto O\n8,320 O\nacres O\n. O\n\nAt O\nthe O\nButte B-MISC\nprospect O\n, O\nthe O\nGarrington B-MISC\n4-8 I-MISC\nhas O\nreached O\ntotal O\ndepth O\nof O\n11,500 O\nand O\nhas O\nlogged O\n278 O\nfeet O\nof O\nLeduc B-LOC\nReef I-LOC\n. O\n\nTesting O\nhas O\nbegun O\nand O\nresults O\nwill O\nbe O\nannounced O\nwithin O\nthe O\nnext O\nseveral O\ndays O\n, O\nArch B-ORG\nsaid O\n. O\n\nIncluding O\nthe O\ncosts O\nof O\nthe O\ntwo O\nabandoned O\nwells O\n, O\nthe O\ncompany O\nsaid O\n, O\nthese O\nfirst O\nprospects O\nhave O\nadded O\nto O\nreserves O\nat O\na O\nfinding O\ncost O\nof O\nabout O\nU.S. B-LOC\n$ O\n2 O\nper O\nbarrel O\nof O\noil O\nequivalent O\n. O\n\n-- O\nJim B-PER\nBrumm I-PER\n212-859-1710 O\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\njudge O\norders O\nBiogen B-ORG\n, O\nBerlex B-ORG\nofficials O\ndeposed O\n. O\n\nLeslie B-PER\nGevirtz I-PER\n\nBOSTON B-LOC\n1996-08-28 O\n\nIn O\norder O\nto O\nhelp O\nhim O\ndecide O\nwhether O\nhe O\nshould O\nhear O\nthe O\ncase O\n, O\na O\nU.S. B-ORG\nDistrict I-ORG\nCourt I-ORG\njudge O\nWednesday O\nordered O\nthe O\nlegal O\ncounsels O\nof O\nBiogen B-ORG\nInc I-ORG\nand O\nBerlex B-ORG\nLaboratories I-ORG\n, O\na O\nsubsidiary O\nof O\nSchering B-ORG\nAG I-ORG\n, O\ndeposed O\n. O\n\nThe O\ntempest O\nbeyond O\nthe O\ntest O\ntube O\ninvolves O\nallegations O\nthat O\nthe O\nU.S. B-ORG\nFood I-ORG\nand I-ORG\nDrug I-ORG\nAdministration I-ORG\nviolated O\nthe O\nOrphan B-MISC\nDrug I-MISC\nlaw I-MISC\nby O\nallowing O\nBiogen B-ORG\nthe O\nright O\nto O\nsell O\nits O\nmultiple O\nsclerosis O\ndrug O\nAvonex B-MISC\n. O\n\nBerlex B-ORG\nalso O\ncharges O\nthat O\nAvonex B-MISC\nis O\nso O\nsimilar O\nto O\nits O\nMS O\ndrug O\n, O\nBetaseron B-MISC\n, O\nthat O\nit O\nis O\na O\npatent O\ninfringement O\n. O\n\nBoth O\ndrugs O\nare O\ntypes O\nof O\ninterferon O\n. O\n\nOne O\nanalyst O\nsaid O\nsales O\nof O\nAvonex B-MISC\nhad O\nalready O\ncut O\ninto O\nBetaseron B-MISC\nmarket O\nshare O\n. O\n\nBioVest B-ORG\nResearch I-ORG\n, I-ORG\nInc I-ORG\n's O\nanalyst O\nEddie B-PER\nHedaya I-PER\nsaid O\n, O\n\" O\nBerlex B-ORG\nsales O\nare O\nlosing O\nshare O\nlike O\nmad O\n... O\n\nmy O\nunderstanding O\nof O\nthe O\nmarketplace O\nis O\nthat O\nthey O\n're O\nbelow O\nexpectations O\n. O\n\" O\n\nHe O\nadded O\nChiron B-ORG\nCorp I-ORG\nreported O\nits O\nsales O\nof O\ninventory O\nto O\nBerlex B-ORG\nwas O\ndown O\n. O\n\nChiron B-ORG\nmakes O\nBetaseron B-MISC\n; O\nBerlex B-ORG\nmarkets O\nit O\n, O\nhe O\nsaid O\n. O\n\nBiogen B-ORG\n, O\nin O\nits O\nSecurities B-ORG\nand I-ORG\nExchange I-ORG\nCommission I-ORG\nquarterly O\nreport O\nfor O\nthe O\nperiod O\nending O\nJune O\n30 O\n, O\nsaid O\nit O\nhad O\nearned O\n$ O\n6.1 O\nmillion O\nfrom O\nAvonex B-MISC\nsales O\nduring O\nthe O\ndrugs O\nfirst O\nsix O\nweeks O\non O\nthe O\nmarket O\n. O\n\nWhen O\nit O\napproved O\nAvonex B-MISC\nin O\nMay O\n, O\nthe O\nFDA B-ORG\nsaid O\nboth O\nBiogen B-ORG\n's O\nproduct O\nand O\nBetaseron B-MISC\nwere O\ndeveloped O\nunder O\nthe O\nincentives O\nof O\nthe O\nOphran B-MISC\nDrug I-MISC\nAct I-MISC\nwhich O\nprovides O\nseven O\nyears O\nof O\nmarketing O\nexclusivity O\nfor O\nproducts O\nthat O\ntreat O\nrare O\ndiseases O\n. O\n\nAvonex B-MISC\n\" O\nhas O\nbeen O\nallowed O\nto O\nenter O\nthe O\nmarket O\nbecause O\nit O\ndiffers O\nfrom O\ninterferon O\nbeta-1b O\n( O\nBetaseron B-MISC\n) O\n.. O\n\n. O\n\" O\n\nthe O\nFDA B-ORG\nsaid O\n. O\n\nNow O\n, O\nU.S. B-LOC\nDistrict O\nJudge O\nMark B-PER\nWolf I-PER\nhas O\nordered O\nthe O\nchief O\ncounsel O\nfor O\nBiogen B-ORG\n, O\nMichael B-PER\nAstrue I-PER\n, O\nand O\nRobert B-PER\nChabora I-PER\n, O\nhis O\ncounterpart O\nat O\nBerlex B-ORG\nbe O\ndeposed O\nabout O\na O\nMay O\n21 O\nmeeting O\nthe O\ntwo O\nmen O\nattended O\nto O\nhelp O\nhim O\ndetermine O\nwhether O\nthe O\nlawsuit O\nfiled O\nby O\nBiogen B-ORG\nagainst O\nBerlex B-ORG\nshould O\nbe O\nheard O\nin O\nMassachusetts B-LOC\n. O\n\nBerlex B-ORG\nfiled O\na O\nlawsuit O\nagainst O\nBiogen B-ORG\nin O\nU.S. B-ORG\nDistrict I-ORG\nCourt I-ORG\nin O\nNewark B-LOC\n, O\nN.J. B-LOC\nin O\nJuly O\n, O\nbut O\nBiogen B-ORG\nhad O\nalready O\nfiled O\na O\nsuit O\nagainst O\nBerlex B-ORG\nin O\nMassachusetts B-LOC\nin O\nMay O\n. O\n\nWolf B-PER\nordered O\nthe O\ndepositions O\nto O\ndetermine O\nif O\nhe O\nor O\nU.S. B-LOC\nDistrict O\nJudge O\nJohn B-PER\nBissell I-PER\nof O\nNewark B-LOC\nshould O\npreside O\nover O\nthe O\ncase O\n. O\n\n-DOCSTART- O\n\nU.S. B-ORG\nTreasury I-ORG\nbalances O\nat O\nFed B-ORG\nrose O\non O\nAug O\n27 O\n. O\n\nWASHINGTON B-LOC\n1996-08-28 O\n\nU.S. B-ORG\nTreasury I-ORG\nbalances O\nat O\nFederal B-ORG\nReserve I-ORG\nbased O\non O\nTreasury B-ORG\nDepartment I-ORG\n's O\nlatest O\nbudget O\nstatement O\n. O\n\n( O\nBILLIONS O\nOF O\nDLRS O\n) O\n\nAug O\n27 O\nAug O\n26 O\n\nFed B-ORG\nacct O\n5.208 O\n4.425 O\n\nTax O\n/ O\nloan O\nnote O\nacct O\n14.828 O\n15.687 O\n\nCash O\nbalance O\n20.036 O\n20.112 O\n\n--- O\n\nTotal O\npublic O\ndebt O\n, O\n\nsubject O\nto O\nlimit O\n5,124.053 O\n5,122.084 O\n\n-DOCSTART- O\n\nCOMEX B-ORG\ncopper O\nends O\nhigher O\nafter O\nlate O\nrecovery O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nCOMEX B-ORG\ncopper O\nended O\nhigher O\nafter O\na O\nlate O\n, O\nmodest O\nrecovery O\ndragged O\nthe O\nmarket O\nfrom O\nthe O\nlows O\n, O\nbut O\ntraders O\nshrugged-off O\nan O\nimminent O\nstrike O\nat O\nCodelco B-ORG\n's O\nSalvador B-LOC\nmine O\nin O\nChile B-LOC\n. O\n\nThe O\nmarket O\nwas O\nalso O\nwaiting O\nfor O\nFriday O\n's O\nLME B-ORG\nstock O\nreport O\nwhich O\nwill O\ninclude O\nfigures O\ndelayed O\nfrom O\nTuesday O\nbecause O\nof O\nthe O\nU.K. B-LOC\npublic O\nholiday O\non O\nMonday O\nwhen O\nthe O\nLME B-ORG\nwas O\nclosed O\n. O\n\n\" O\nWe O\nare O\nin O\nthe O\nlate O\nstages O\nof O\nthe O\nweaker O\nperiod O\nof O\nthe O\nmarket O\n, O\nand O\nas O\nwe O\nget O\nto O\nthe O\npost O\nLabor B-MISC\nDay I-MISC\nmarket O\nwe O\nwill O\nstart O\nto O\nsee O\nmore O\nconsumer O\ninterest O\nand O\nthe O\ndemand O\nside O\nof O\nthe O\nmarket O\nwill O\nstart O\nto O\nfirm O\nprices O\nup O\n, O\n\" O\nsaid O\nWilliam B-PER\nO'Neill I-PER\nof O\nMerrill B-ORG\nLynch I-ORG\n. O\n\nDecember O\nCOMEX B-ORG\nsettled O\n0.35 O\ncent O\nhigher O\nat O\n90.20 O\ncents O\n, O\ntraded O\n90.50 O\nto O\n89.40 O\ncents O\n. O\n\nSeptember O\nwent O\nout O\n0.05 O\ncent O\nlower O\nat O\n91.05 O\n. O\n\nThe O\nAugust O\ncontract O\nexpired O\nat O\n0.85 O\ncent O\ndown O\nat O\n90.85 O\ncents O\n. O\n\nVolume O\nwas O\nestimated O\nat O\n8,000 O\nlots O\n. O\n\nWorkers O\nat O\nSalvador B-LOC\nvoted O\nto O\nstrike O\nfrom O\nSaturday O\n, O\nand O\nit O\nwas O\nnot O\nclear O\nwhen O\nfurther O\ntalks O\nbetween O\nthe O\nunions O\nand O\nmanagement O\nwould O\ntake O\nplace O\n. O\n\n\" O\nSalvador B-LOC\nis O\na O\nsmall O\nfacility O\n, O\nand O\nthe O\nprospects O\nare O\nthat O\nif O\nthere O\nwill O\nbe O\na O\nstrike O\n, O\nit O\nwill O\nnot O\nbe O\na O\nlong O\nstrike O\n, O\n\" O\nO'Neill B-PER\nsaid O\n. O\n\n-- O\nHuw B-PER\nJones I-PER\n, O\nNew B-ORG\nYork I-ORG\nCommodities I-ORG\n212-859-1646 O\n\n-DOCSTART- O\n\nU.S. B-LOC\ncopper O\nservice O\ncenter O\nshipments O\nstable O\n- O\nCBSA B-ORG\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nAverage O\ndaily O\nshipments O\nfrom O\nU.S. B-LOC\ncopper O\nservice O\ncenters O\nin O\nJuly O\nfell O\nthree O\npercent O\nfrom O\nthe O\nprevious O\nmonth O\n, O\nbut O\nwere O\nhigher O\nthan O\nin O\nJuly O\n1995 O\n, O\nthe O\nCopper B-ORG\nand I-ORG\nBrass I-ORG\nServicenter I-ORG\nAssociation I-ORG\nreported O\n. O\n\n\" O\nJuly O\nwas O\nstill O\nabove O\nthe O\nhistoric O\naverage O\nfor O\nthat O\nmonth O\n, O\n\" O\nthe O\nCBSA B-ORG\nsaid O\n. O\n\nIn O\nthe O\nfirst O\nseven O\nmonths O\nof O\n1996 O\n, O\nshipments O\nof O\ncopper O\nsheet O\n, O\ncoil O\nand O\nstrip O\nwere O\n2.2 O\npercent O\nahead O\nof O\nthe O\nsame O\nperiod O\nlast O\nyear O\n. O\n\nAlloy O\nshipments O\n, O\nhowever O\n, O\nwere O\n7.5 O\npercent O\ndown O\n. O\n\n\" O\nSeveral O\nservice O\ncenters O\nindicated O\nthat O\nwhile O\ntheir O\nvolume O\nof O\norders O\nremains O\nconstant O\n, O\nthe O\nsize-per-order O\ncontinues O\nto O\nbe O\nsmaller O\nthan O\nwhat O\nwas O\nrealised O\nduring O\nthe O\nfirst O\nfive O\nmonths O\nof O\nthe O\nyear O\n, O\n\" O\nthe O\nCBSA B-ORG\nsaid O\n. O\n\nService O\ncenters O\ncontinued O\nto O\nlower O\ntheir O\ninventories O\nin O\nJuly O\nwhen O\ntotal O\ncopper O\nstocks O\nwere O\noff O\ntwo O\npercent O\nand O\nalloy O\nproducts O\ndown O\n1.9 O\npercent O\n. O\n\n-- O\nNew B-ORG\nYork I-ORG\nCommodities I-ORG\n212-859-1646 O\n\n-DOCSTART- O\n\nHarleysville B-ORG\nGroup I-ORG\nups O\nqrtly O\ndividenD O\n. O\n\nHARLEYSVILLE B-LOC\n, O\nPa B-LOC\n. O\n\n1996-08-28 O\n\nQuarterly O\n\nLatest O\nPrior O\n\nAmount O\n$ O\n0.21 O\n$ O\n0.19 O\n\nPay O\nSept O\n30 O\n\nRecord O\nSept O\n16 O\n\n-DOCSTART- O\n\nChile B-LOC\n's O\nENAP B-ORG\nbuys O\nOriente B-ORG\n, O\nEscravos B-ORG\ncrude O\nfor O\nOct O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nChile B-LOC\n's O\nstate O\noil O\ncompany O\nEmpresa B-ORG\nNacional I-ORG\ndel I-ORG\nPetroleo I-ORG\n( O\nENAP B-ORG\n) O\nbought O\na O\nsecond O\nspot O\ncargo O\nof O\nOriente B-ORG\nand O\nnearly O\none O\nmillion O\nbarrels O\nof O\nEscravos B-ORG\nin O\na O\nrecent O\ntender O\n, O\ntraders O\nsaid O\nWednesday O\n. O\n\nA O\n400,000 O\nbarrel O\ncargo O\nof O\nEcuadorian B-ORG\nOriente I-ORG\nand O\n960,000 O\nbarrels O\nof O\nNigerian B-MISC\nEscravos B-ORG\nwas O\nawarded O\nin O\na O\ntender O\nfor O\nOct O\n15-18 O\nlate O\nlast O\nweek O\n, O\nbut O\nprice O\ninformation O\nremains O\nvague O\n. O\n\n\" O\nThe O\nOriente B-ORG\nwill O\nbe O\nsupplied O\nby O\nthe O\nsame O\nseller O\nat O\na O\nsmall O\npremium O\nto O\nformula O\n, O\n\" O\na O\ntrade O\nsource O\nsaid O\n, O\nreferring O\nto O\nthe O\nfirst O\nOctober O\ncargo O\nsold O\ntwo O\nweeks O\nago O\nat O\nPetroecuador B-ORG\n's O\nsale O\nformula O\nplus O\nfive O\ncents O\nfob O\n. O\n\nEscravos B-ORG\nwas O\nsold O\non O\na O\nDated B-MISC\nBrent I-MISC\nrelated O\nbasis O\n, O\nwith O\npremiums O\nfor O\nthe O\nlight O\ngrade O\nseen O\nin O\nthe O\nlow O\n50-cent O\nrange O\n. O\n\nThe O\nnext O\npurchase O\ntender O\nfrom O\nENAP B-ORG\nis O\nexpected O\nfor O\nlate O\nOctober O\nor O\nearly O\nNovember O\ncrude O\n, O\ntraders O\nsaid O\n. O\n\n-- O\nJacqueline B-PER\nWong I-PER\n, O\nNew B-ORG\nYork I-ORG\nEnergy I-ORG\nDesk I-ORG\n+1 O\n212 O\n859 O\n1620 O\n\n-DOCSTART- O\n\nReuters B-ORG\nhistorical O\ncalendar O\n- O\nSeptember O\n4 O\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nFollowing O\nare O\nsome O\nof O\nthe O\nmajor O\nevents O\nto O\nhave O\noccurred O\non O\nSeptember O\n4 O\nin O\nhistory O\n. O\n\n1241 O\n- O\nAlexander B-PER\nIII I-PER\n, O\nKing O\nof O\nScotland B-LOC\n, O\nborn O\n. O\n\nKing O\nfrom O\n1249-1286 O\n, O\nhe O\nconsolidated O\nroyal O\npower O\n, O\nleaving O\nScotland B-LOC\nunited O\nand O\nindependent O\n. O\n\n1260 O\n- O\nThe O\nGhibellines B-MISC\nretook O\nthe O\ncity O\nof O\nFlorence B-LOC\nfrom O\nthe O\nFlorentine B-LOC\nGuelfs I-LOC\nat O\nthe O\nbattle O\nof O\nMonte B-LOC\nAperto I-LOC\n. O\n\n1768 O\n- O\nFrancois-Rene B-PER\n( I-PER\nVicomte I-PER\nde I-PER\n) I-PER\nChateaubriand I-PER\nborn O\n. O\n\nHe O\nwas O\na O\npolitician O\n, O\none O\nof O\nthe O\nfirst O\nFrench B-MISC\nromantic O\nwriters O\nand O\nambassador O\nto O\nthe O\nBritish B-MISC\ncourt O\n. O\n\nHe O\nwrote O\n\" O\nRene B-MISC\n\" O\n, O\na O\nseminal O\nwork O\nin O\nthe O\nFrench B-MISC\nromantic O\nmovement O\nand O\na O\nfamous O\nautobiography O\n\" O\nMemoires B-MISC\nd'Outre I-MISC\nTombe I-MISC\n\" O\n. O\n\n1781 O\n- O\nLos B-LOC\nAngeles I-LOC\nwas O\nfounded O\nby O\nSpanish B-MISC\nsettlers O\nand O\nnamed O\n\" O\nEl B-LOC\nPueblo I-LOC\nde I-LOC\nNuestra I-LOC\nSenora I-LOC\nLa I-LOC\nReina I-LOC\nde I-LOC\nLos I-LOC\nAngeles I-LOC\n\" O\n( O\nThe B-LOC\nTown I-LOC\nof I-LOC\nOur I-LOC\nLady I-LOC\nthe I-LOC\nQueen I-LOC\nof I-LOC\nthe I-LOC\nAngels I-LOC\n) O\n. O\n\n1824 O\n- O\nAnton B-PER\nBruckner I-PER\nborn O\n. O\n\nAustrian B-MISC\ncomposer O\nand O\norganist O\n, O\nhe O\nwrote O\nnine O\nsymphonies O\non O\na O\nhuge O\nscale O\nand O\nthree O\ngrand O\nmasses O\nin O\nthe O\nromantic O\ntradition O\n. O\n\n1870 O\n- O\nIn O\nFrance B-LOC\n, O\nthe O\nSecond B-MISC\nEmpire I-MISC\nwas O\nended O\nand O\nNapoleon B-PER\nIII I-PER\nwas O\ndeposed O\nafter O\nhis O\nsurrender O\ntwo O\ndays O\nearlier O\nin O\nthe O\nFranco-Prussian B-MISC\nwar O\n. O\n\n1886 O\n- O\nAt O\nSkeleton B-LOC\nCanyon I-LOC\nin O\nArizona B-LOC\n, O\nGeronimo B-PER\n, O\nApache O\nchief O\nand O\nleader O\nof O\nthe O\nlast O\ngreat O\nRed B-MISC\nIndian I-MISC\nrebellion O\nfinally O\nsurrendered O\nto O\nGeneral O\nNelson B-PER\nMiles I-PER\n. O\n\n1892 O\n- O\nProlific O\nFrench B-MISC\nmodernist O\ncomposer O\nDarius B-PER\nMilhaud I-PER\nborn O\n. O\n\nHe O\nwrote O\na O\njazz O\nballet O\n\" O\nLa B-MISC\nCreation I-MISC\ndu I-MISC\nMonde I-MISC\n\" O\nand O\nscores O\nfor O\nmany O\nfilms O\nincluding O\nan O\nearly O\nversion O\nof O\n\" O\nMadame B-MISC\nBovary I-MISC\n\" O\n. O\n\n1906 O\n- O\nGerman-born O\nU.S. B-LOC\nbiologist O\nMax B-PER\nDelbruck I-PER\nborn O\n. O\n\nWinner O\nof O\nthe O\n1969 O\nNobel B-MISC\nPrize I-MISC\nfor O\nphysiology O\nor O\nmedicine O\nfor O\nwork O\non O\nthe O\ngenetic O\nstructure O\nof O\nviruses O\nthat O\ninfect O\nbacteria O\n. O\n\n1907 O\n- O\nEdvard B-PER\nGrieg I-PER\n, O\nNorwegian B-MISC\ncomposer O\nbest O\nknown O\nfor O\nhis O\n\" O\nPeer B-MISC\nGynt I-MISC\nSuite I-MISC\n\" O\nand O\nhis O\nPiano O\nConcerto O\n, O\ndied O\nin O\nBergen B-LOC\n. O\n\n1908 O\n- O\nU.S. B-LOC\nfilm O\ndirector O\nEdward B-PER\nDmytryk I-PER\nborn O\n. O\n\nBest O\nknown O\nfor O\nhis O\nfilms O\n\" O\nCrossfire B-MISC\n\" O\n- O\none O\nof O\nHollywood B-LOC\n's O\nfirst O\nattempts O\nto O\ndeal O\nwith O\nracial O\ndiscrimination O\nand O\n\" O\nFarewell B-MISC\nMy I-MISC\nlovely I-MISC\n\" O\n. O\n\n1909 O\n- O\nThe O\nworld O\n's O\nfirst O\nBoy B-MISC\nScout I-MISC\nRally I-MISC\nwas O\nheld O\nat O\nCrystal B-ORG\nPalace I-ORG\nnear O\nLondon B-LOC\n. O\n\n1944 O\n- O\nBrussels B-LOC\nand O\nAntwerp B-LOC\nin O\nBelgium B-LOC\nwere O\nliberated O\nby O\nBritish B-MISC\nand O\nCanadian B-MISC\ntroops O\nin O\nWorld B-MISC\nWar I-MISC\nTwo I-MISC\n. O\n\n1948 O\n- O\nWilhelmina B-PER\n, O\nQueen O\nof O\nthe O\nNetherlands B-LOC\nfrom O\n1890 O\nand O\nthroughout O\nWorld B-MISC\nWars I-MISC\nOne I-MISC\nand O\nTwo B-MISC\nabdicated O\nin O\nfavour O\nof O\nher O\ndaughter O\nJuliana B-PER\n. O\n\n1963 O\n- O\nRobert B-PER\nSchuman I-PER\n, O\nFrench B-MISC\nstatesman O\n, O\nPrime O\nMinister O\n1947-48 O\nand O\nForeign O\nMinister O\n1948-52 O\n, O\ndied O\n. O\n\nHe O\nwas O\nresponsible O\nfor O\nthe O\nestablishment O\nof O\nthe O\nEuropean B-ORG\nCoal I-ORG\nand I-ORG\nSteel I-ORG\nCommunity I-ORG\n. O\n\n1964 O\n- O\nThe O\nForth B-LOC\nRoad I-LOC\nBridge I-LOC\nin O\nScotland B-LOC\n, O\nmeasuring O\n6156 O\nft O\n, O\nand O\nwith O\na O\ncentre O\nspan O\nof O\n3300 O\nft O\n, O\nwas O\nopened O\nby O\nHer O\nMajesty O\nthe O\nQueen O\n. O\n\n1965 O\n- O\nAlbert B-PER\nSchweitzer I-PER\n, O\ntheologian O\n, O\nphilosopher O\nand O\norganist O\ndied O\nin O\nGabon B-LOC\nwhere O\nhe O\nhad O\nset O\nup O\na O\nhospital O\nin O\n1913 O\n. O\n\nAcclaimed O\nfor O\nhis O\ninterpretations O\nof O\nJ.S. B-PER\nBach I-PER\n's O\nworks O\n, O\nhe O\nalso O\nwon O\nthe O\nNobel B-MISC\nPeace I-MISC\nPrize I-MISC\nfor O\nhis O\nefforts O\non O\nbehalf O\nof O\nthe O\n\" O\nBrotherhood B-ORG\nof I-ORG\nNations I-ORG\n\" O\nin O\n1952 O\n. O\n\n1972 O\n- O\nAt O\nthe O\nOlympic B-MISC\nGames I-MISC\n, O\nU.S. B-LOC\nswimmer O\nMark B-PER\nSpitz I-PER\nwon O\nhis O\nseventh O\ngold O\nmedal O\n, O\na O\nrecord O\nfor O\na O\nsingle O\nOlympiad B-MISC\n. O\n\n1974 O\n- O\nEast B-LOC\nGermany I-LOC\nand O\nthe O\nUnited B-LOC\nStates I-LOC\nestablished O\nformal O\ndiplomatic O\nrelations O\nfor O\nthe O\nfirst O\ntime O\n. O\n\n1977 O\n- O\nE.F. B-PER\n( I-PER\nFritz I-PER\n) I-PER\nSchumacher I-PER\n, O\neconomic O\nguru O\nand O\nauthor O\nof O\nthe O\nbest O\nseller O\n\" O\nSmall B-MISC\nis I-MISC\nBeautiful I-MISC\n\" O\n, O\ndied O\non O\nhis O\nway O\nto O\na O\nconference O\nin O\nSwitzerland B-LOC\n. O\n\n1989 O\n- O\nGeorges B-PER\nSimenon I-PER\n, O\nwriter O\nof O\n84 O\nbooks O\nbased O\non O\nthe O\ndetective O\ncharacter O\nInspector B-PER\nMaigret I-PER\n, O\ndied O\n. O\n\n1992 O\n- O\nBulgaria B-LOC\n's O\nformer O\nCommunist B-MISC\nleader O\nTodor B-PER\nZhivkov I-PER\n, O\ndeposed O\nin O\n1989 O\n, O\nwas O\nsentenced O\nto O\nseven O\nyears O\nin O\nprison O\nafter O\nbeing O\nfound O\nguilty O\nof O\nembezzling O\nstate O\nfunds O\n. O\n\n1995 O\n- O\nDeclaring O\n\" O\nunited O\nJerusalem B-LOC\nis O\nours O\n\" O\n, O\nIsrael B-LOC\nlaunched O\na O\n15-month O\ncelebration O\nof O\nthe O\n3,000th O\nanniversary O\nof O\nKing O\nDavid B-PER\n's O\nproclamation O\nof O\nthe O\ncity O\nas O\nthe O\ncapital O\nof O\nthe O\nJewish B-MISC\npeople O\n. O\n\n1995 O\n- O\nThe O\nFourth B-MISC\nWorld I-MISC\nConference I-MISC\non I-MISC\nWomen I-MISC\n, O\nthe O\nbiggest O\nU.N. B-ORG\ngathering O\nin O\nhistory O\n, O\nbegan O\nin O\nChina B-LOC\n's O\nGreat B-LOC\nHall I-LOC\nof I-LOC\nthe I-LOC\nPeople I-LOC\nwith O\na O\nU.N. B-ORG\ndeclaration O\nthat O\nsexual O\nequality O\nwas O\nthe O\nlast O\ngreat O\nproject O\nof O\nthe O\n20th O\ncentury O\n. O\n\n-DOCSTART- O\n\nUK B-LOC\nlowers O\nnoise O\nlimits O\nfor O\nthree O\nLondon B-LOC\nairports O\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nThe O\nBritish B-MISC\ngovernment O\non O\nWednesday O\nlowered O\nthe O\nnoise O\nlimits O\nfor O\nLondon B-LOC\n's O\nHeathrow B-LOC\n, O\nGatwick B-LOC\nand O\nStansted B-LOC\nairports O\nand O\nannounced O\nit O\nwould O\nmake O\na O\nbigger O\neffort O\nin O\ndetecting O\nand O\nfining O\nviolators O\n. O\n\nThe O\nlimits O\n, O\neffective O\nfrom O\nJanuary O\n1 O\n, O\n1997 O\n, O\nare O\nreduced O\nas O\nmuch O\nas O\npossible O\nwhile O\nstill O\ncomplying O\nwith O\ninternational O\nobligations O\n, O\na O\nspokesman O\nfor O\nthe O\nDepartment B-ORG\nof I-ORG\nTransport I-ORG\nsaid O\n. O\n\nThe O\nmaximum O\nnoise O\nlevel O\nduring O\nthe O\nday O\nis O\ntrimmed O\nby O\nthree O\ndecibels O\nto O\n94 O\n, O\nwhile O\nthe O\nnight O\ntime O\nlevel O\nis O\nreduced O\nby O\ntwo O\ndecibels O\nto O\n87 O\n. O\n\n\" O\nIt O\nis O\na O\nsmaller O\nreduction O\nin O\nterms O\nof O\nloudness O\nthan O\nwas O\nsought O\nby O\nlocal O\npeople O\n. O\n\nNevertheless O\nI O\nam O\nsatisfied O\nthat O\nthe O\noverall O\nbenefits O\nwill O\nbe O\nworthwile O\n, O\n\" O\nLord O\nGoschen B-PER\n, O\nminister O\nfor O\naviation O\n, O\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nministry O\nsaid O\nit O\nbelieved O\nthe O\nnew O\nlimits O\ncould O\nbe O\nmet O\nwith O\nexisting O\naircraft O\n. O\n\" O\n\nThey O\ncan O\nbe O\nflown O\nin O\nquieter O\nways O\n, O\n\" O\na O\nspokesman O\nsaid O\n. O\n\nThe O\nreduction O\nin O\nnoise O\nlevels O\nis O\nthe O\nsame O\nas O\nproposed O\nin O\na O\nconsultation O\npaper O\nwhich O\nwas O\npublished O\nin O\nOctober O\n1995 O\n. O\n\nThe O\npresent O\nnoise O\nlevels O\nhave O\napplied O\nat O\nHeathrow B-LOC\n, O\none O\nof O\nthe O\nworld O\n's O\nbusiest O\nairports O\n, O\nsince O\n1959 O\nand O\nat O\nGatwick B-LOC\nsince O\n1968 O\n. O\n\nThe O\nnumber O\nof O\nmonitors O\nwill O\nbe O\nincreased O\nand O\nsome O\nwill O\nbe O\nrepositioned O\nto O\ndetect O\nnoisy O\nplanes O\n. O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n7717 O\n\n-DOCSTART- O\n\nTennis O\n- O\nPhilippoussis B-PER\nbeats O\nWoodforde B-PER\nin O\nU.S. B-MISC\nOpen I-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-27 O\n\nMark B-PER\nPhilippoussis I-PER\nbeat O\nfellow O\nAustralian B-MISC\nMark B-PER\nWoodforde I-PER\n6-7 O\n( O\n6-8 O\n) O\n6-3 O\n6-3 O\n6-3 O\nin O\na O\nmen O\n's O\nsingles O\nfirst O\nround O\nmatch O\nat O\nthe O\nU.S. B-MISC\nOpen I-MISC\non O\nTuesday O\n. O\n\nThe O\ntwo O\nDavis B-MISC\nCup I-MISC\nteam-mates O\nwere O\npitted O\nagainst O\neach O\nother O\nafter O\nlast O\nweek O\n's O\ncontroversial O\nredraw O\nof O\nthe O\nmen O\n's O\nsingles O\ncompetition O\n. O\n\nPhilippoussis B-PER\nis O\non O\ncourse O\nfor O\na O\nthird O\nround O\nmeeting O\nwith O\nworld O\nnumber O\none O\nPete B-PER\nSampras I-PER\nof O\nthe O\nUnited B-LOC\nStates I-LOC\n, O\nwhom O\nhe O\nbeat O\nat O\nthe O\nAustralian B-MISC\nOpen I-MISC\nlast O\nJanuary O\n. O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373-1800 O\n\n-DOCSTART- O\n\nRugby O\nunion-England B-MISC\ngiven O\nfinal O\nchance O\nto O\nstay O\nin O\nFive B-MISC\nNations I-MISC\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nEngland B-LOC\nhave O\nbeen O\ngiven O\na O\nfinal O\nchance O\nto O\nremain O\nin O\nthe O\nFive B-MISC\nNations I-MISC\n' O\nchampionship O\ndespite O\nstriking O\nan O\nexclusive O\ntelevision O\ndeal O\nwith O\nRupert B-PER\nMurdoch I-PER\n's O\nSky B-ORG\ntelevision O\n. O\n\nIn O\na O\nstatement O\non O\nWednesday O\n, O\nthe O\nFour B-ORG\nNations I-ORG\nTV I-ORG\nCommittee I-ORG\nsaid O\ndates O\nhad O\nbeen O\nset O\nfor O\na O\ncompetition O\ninvolving O\nScotland B-LOC\n, O\nWales B-LOC\n, O\nIreland B-LOC\nand O\nFrance B-LOC\nnext O\nyear O\n. O\n\n\" O\nBetween O\nnow O\nand O\nthen O\n, O\ndiscussions O\nwill O\ntake O\nplace O\nin O\none O\nfinal O\nattempt O\nto O\npersuade O\nthe O\nRugby B-ORG\nFootball I-ORG\nUnion I-ORG\nto O\nsave O\nthe O\nFive B-MISC\nNations I-MISC\n' O\nchampionship O\nin O\nits O\ncurrent O\nform O\n, O\n\" O\nthe O\nstatement O\nsaid O\n. O\n\nNo O\nfurther O\ndetails O\nwere O\nimmediately O\navailable O\n. O\n\nEngland B-LOC\ninfuriated O\ntheir O\nchampionship O\ncolleagues O\nwhen O\nthey O\ndecided O\nto O\nsign O\na O\n87.5 O\nmillion O\npounds O\nsterling O\n( O\n$ O\n135.8 O\nmillion O\n) O\ndeal O\ngiving O\nSky B-ORG\ntelevision O\nexclusive O\nrights O\nto O\nrugby O\nunion O\nmatches O\nin O\nEngland B-LOC\n. O\n\nThe O\npresent O\ncontract O\nwith O\nthe O\nBritish B-ORG\nBroadcasting I-ORG\nCorporation I-ORG\nwas O\nshared O\nbetween O\nthe O\nfour O\nhome O\nnations O\nwhile O\nFrance B-LOC\nhave O\ntheir O\nown O\ntelevision O\ndeal O\n. O\n\nLast O\nmonth O\nFive B-MISC\nNations I-MISC\n' O\ncommittee O\nchairman O\nTom B-PER\nKiernan I-PER\nsaid O\nEngland B-LOC\nwould O\nbe O\nthrown O\nout O\nof O\nthe O\ncompetition O\n\" O\nunless O\ncircumstances O\nchange O\nin O\nthe O\nnear O\nfuture O\n\" O\n. O\n\n-DOCSTART- O\n\nCricket O\n- O\nNZ B-LOC\nface O\ntough O\nschedule O\nat O\nhome O\nand O\nabroad O\n. O\n\nWELLINGTON B-LOC\n1996-08-28 O\n\nWorld B-MISC\nCup I-MISC\ncricket O\nchampions O\nSri B-LOC\nLanka I-LOC\nwill O\nplay O\ntwo O\ntests O\nand O\nthree O\none-day O\ninternationals O\nin O\na O\ntour O\nof O\nNew B-LOC\nZealand I-LOC\nnext O\nMarch O\n, O\nofficials O\nsaid O\non O\nWednesday O\n. O\n\nNew B-LOC\nZealand I-LOC\nCricket O\nsaid O\nthe O\nSri B-MISC\nLankans I-MISC\nwould O\nplay O\ntests O\nin O\nHamilton B-LOC\nand O\nWellington B-LOC\nand O\none-dayers O\nin O\nAuckland B-LOC\n, O\nChristchurch B-LOC\nand O\nDunedin B-LOC\n, O\nfollowing O\nhard O\non O\nthe O\nheels O\nof O\na O\ntour O\nby O\nEngland B-LOC\n. O\n\nNew B-LOC\nZealand I-LOC\nwill O\nalso O\nline O\nup O\nagainst O\nSri B-LOC\nLanka I-LOC\nand O\nPakistan B-LOC\nthis O\nNovember O\nin O\na O\none-day O\nchampions O\ntrophy O\ncompetition O\nin O\nSharjah B-LOC\n. O\n\nThe O\nteam O\nwill O\ngo O\none O\nto O\ntour O\nPakistan B-LOC\n, O\nplaying O\ntwo O\ntests O\nand O\nthree O\none-day O\ninternationals O\n. O\n\n-DOCSTART- O\n\nSoccer O\n- O\nBurundi B-LOC\ndisqualification O\nfrom O\nAfrican B-MISC\nCup I-MISC\nconfirmed O\n. O\n\nCAIRO B-LOC\n1996-08-28 O\n\nThe O\nAfrican B-LOC\nFootball I-LOC\nConfederation I-LOC\n( O\nCAF B-ORG\n) O\non O\nWednesday O\nformally O\nconfirmed O\nBurundi B-LOC\n's O\ndisqualification O\nfrom O\nthe O\nAfrican B-MISC\nNations I-MISC\nCup I-MISC\nfollowing O\nthe O\nteam O\n's O\ninability O\nto O\ntravel O\nfor O\na O\nqualifier O\nagainst O\nCentral B-LOC\nAfrican I-LOC\nRepublic I-LOC\n. O\n\nThe O\nBurundi B-LOC\nteam O\nwere O\nunable O\nto O\nleave O\ntheir O\ntroubled O\ncountry O\nfor O\na O\npreliminary O\nround O\nfirst O\nleg O\nmatch O\nin O\nBangui B-LOC\nearlier O\nthis O\nmonth O\nbecause O\nof O\nan O\nair O\nban O\nimposed O\nin O\na O\nrecent O\nset O\nof O\ninternationally-sponsored O\nsanctions O\n. O\n\nThe O\nCentral B-LOC\nAfrican I-LOC\nRepublic I-LOC\nqualified O\non O\na O\nwalkover O\nto O\nplay O\nin O\ngroup O\nfour O\nwith O\nGuinea B-LOC\n, O\nSierra B-LOC\nLeone I-LOC\nand O\nTunisia B-LOC\n. O\n\n\" O\nAfter O\nexamining O\nthe O\ndossier O\nof O\nthe O\nBurundi-Central B-MISC\nAfrica I-MISC\nmatch O\n, O\nwe O\ndecided O\n... O\n\nto O\ndisqualify O\nthe O\nnational O\nteam O\nof O\nBurundi B-LOC\nfrom O\nthe O\n21st B-MISC\nAfrican I-MISC\nCup I-MISC\nof I-MISC\nNations I-MISC\n... O\n\nas O\na O\nresult O\nof O\nthe O\nabsence O\nof O\nthis O\nteam O\nfrom O\nthe O\nmatch O\n, O\n\" O\nCAF B-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\n-DOCSTART- O\n\nCricket O\n- O\nIndia B-LOC\n226-5 O\nin O\n50 O\novers O\nv O\nSri B-LOC\nLanka I-LOC\n. O\n\nCOLOMBO B-LOC\n1996-08-28 O\n\nIndia B-LOC\nscored O\n226 O\nfor O\nfive O\nwickets O\nin O\ntheir O\n50 O\novers O\nagainst O\nSri B-LOC\nLanka I-LOC\nin O\nthe O\nsecond O\nday-night O\nlimited O\novers O\nmatch O\nof O\nthe O\nSinger B-MISC\nWorld I-MISC\nSeries I-MISC\ntournament O\non O\nWednesday O\n. O\n\n-DOCSTART- O\n\nCanada B-LOC\nfast-tracks O\nChinese B-MISC\nasylum-seekers O\n- O\nreport O\n. O\n\nVANCOUVER B-LOC\n, O\nBritish B-LOC\nColumbia I-LOC\n1996-08-28 O\n\nCanada B-LOC\nis O\nfast-tracking O\nimmigration O\napplications O\nfrom O\nChinese B-MISC\ndissidents O\nin O\nHong B-LOC\nKong I-LOC\nbefore O\nthe O\nBritish B-MISC\ncolony O\nreverts O\nto O\nChina B-LOC\n's O\ncontrol O\nnext O\nyear O\n, O\nthe O\nVancouver B-ORG\nSun I-ORG\nreported O\non O\nWednesday O\n. O\n\nThe O\napplications O\nare O\nbeing O\n\" O\nfast-tracked O\nin O\nthe O\nsense O\nthat O\nwe O\nare O\nprocessing O\nthem O\nand O\nthe O\nones O\nwho O\nhave O\nbeen O\nreferred O\nto O\nus O\nhave O\nbeen O\ninterviewed O\n, O\n\" O\nthe O\nnewspaper O\nquoted O\nGarrett B-PER\nLambert I-PER\n, O\nCanada B-LOC\n's O\nhigh O\ncommissioner O\nin O\nHong B-LOC\nKong I-LOC\n, O\nas O\nsaying O\n. O\n\n\" O\nA O\nsmall O\nnumber O\nalready O\nhave O\npreliminary O\nindications O\nas O\nto O\nwhat O\nthe O\ndisposition O\nof O\ntheir O\ncases O\nare O\nand O\nso O\nI O\nsuppose O\nin O\nthat O\nsense O\n, O\nI O\nguess O\nwe O\nhave O\ngiven O\nthem O\nsome O\npreferential O\ntreatment O\n, O\n\" O\nLambert B-PER\nsaid O\n. O\n\nHe O\ndeclined O\nto O\nsay O\nhow O\nmany O\npeople O\nwere O\nbeing O\nconsidered O\nfor O\nasylum O\n. O\n\nCanada B-LOC\n's O\nministry O\nof O\nforeign O\naffairs O\nin O\nOttawa B-LOC\nhad O\nno O\nimmediate O\ncomment O\non O\nthe O\nreport O\n. O\n\nAbout O\n80 O\nChinese B-MISC\ndissidents O\nare O\nbelieved O\nto O\nbe O\nliving O\nin O\nexile O\nin O\nHong B-LOC\nKong I-LOC\n. O\n\nTheir O\nfate O\nafter O\nthe O\nterritory O\nreverts O\nto O\nChinese B-MISC\nrule O\nis O\nunclear O\n. O\n\nBritain B-LOC\nhands O\nHong B-LOC\nKong I-LOC\nback O\nto O\nChina B-LOC\nat O\nmidnight O\non O\nJune O\n30 O\n, O\n1997 O\n, O\nafter O\n150 O\nyears O\nof O\ncolonial O\nrule O\n. O\n\nCanada B-LOC\n's O\nMinister O\nof O\nForeign O\nAffairs O\nLloyd B-PER\nAxworthy I-PER\nsaid O\nafter O\nmeeting O\nHong B-LOC\nKong I-LOC\nGov O\n. O\n\nChris B-PER\nPatten I-PER\nlast O\nmonth O\nthat O\nCanada B-LOC\nmay O\ngrant O\nasylum O\nto O\ndissidents O\nwho O\nhave O\nfled O\nto O\nHong B-LOC\nKong I-LOC\nfrom O\nChina B-LOC\n. O\n\nChinese B-MISC\nofficials O\nhave O\nsaid O\nsuch O\ndissidents O\nmay O\nnot O\nbecome O\nHong B-LOC\nKong I-LOC\npermanent O\nresidents O\nsince O\nthey O\nentered O\nthe O\nterritory O\nillegally O\nbut O\nhave O\nalso O\nsaid O\ntheir O\nstatus O\nwould O\nbe O\ndecided O\nby O\nthe O\npost-1997 O\nlocal O\nHong B-LOC\nKong I-LOC\nadministration O\n. O\n\n-DOCSTART- O\n\nIvorian B-MISC\njournalist O\nheld O\n, O\nasked O\nto O\nreveal O\nsource O\n. O\n\nABIDJAN B-LOC\n1996-08-28 O\n\nAn O\nIvorian B-MISC\njournalist O\nspent O\na O\nthird O\nday O\nin O\ncustody O\non O\nWednesday O\nand O\ninvestigators O\nwere O\ndemanding O\nthat O\nhe O\nreveal O\nthe O\nsource O\nof O\nan O\nofficial O\ndocument O\npublished O\nin O\nhis O\nnewspaper O\n, O\ncolleagues O\nsaid O\n. O\n\nRaphael B-PER\nLapke I-PER\n, O\npublication O\ndirector O\nof O\nIvorian B-MISC\nnewspaper O\nLe B-ORG\nPopulaire I-ORG\n, O\nwas O\ntaken O\nin O\nfor O\nquestioning O\non O\nMonday O\nover O\nan O\narticle O\nabout O\nthe O\npublic O\nprosecutor O\nand O\nhas O\nbeen O\ndetained O\nsince O\nthen O\n. O\n\nColleagues O\nsaid O\nhe O\nhad O\nbeen O\ncharged O\nwith O\ntheft O\nof O\nadministrative O\ndocuments O\n. O\n\" O\n\nHe O\nis O\nbeing O\nasked O\nfor O\nthe O\nsource O\nof O\nhis O\ninformation O\nand O\nwho O\ngave O\nhim O\nthis O\nconfidential O\ndocument O\n, O\n\" O\none O\ncolleague O\ntold O\nReuters B-ORG\n. O\n\nThree O\njournalists O\nfrom O\nthe O\nIvorian B-MISC\nopposition O\ndaily O\nLa B-ORG\nVoie I-ORG\nare O\nserving O\ntwo-year O\nprison O\nterms O\nfor O\ninsulting O\nPresident O\nHenri B-PER\nKonan I-PER\nBedie I-PER\n. O\n\nA O\ncourt O\nsentenced O\ntwo O\nin O\nDecember O\nand O\nthe O\nthird O\nin O\nJanuary O\n. O\n\nLa B-ORG\nVoie I-ORG\npublished O\nan O\narticle O\nsuggesting O\nthe O\npresence O\nof O\nBedie B-PER\nhad O\nbrought O\nlocal O\nteam O\nASEC B-ORG\nbad O\nluck O\nduring O\ntheir O\ndefeat O\nby O\nOrlando B-PER\nPirates I-PER\nof O\nSouth B-LOC\nAfrica I-LOC\nin O\nthe O\nfinal O\nof O\nthe O\nAfrican B-MISC\nChampions I-MISC\nCup I-MISC\nin O\nDecember O\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\nembassy O\nin O\nAbidjan B-LOC\nand O\ninternational O\npress O\norganisations O\ndenounced O\nthe O\nsentences O\nas O\nexcessive O\n. O\n\nLast O\nyear O\n, O\nBedie B-PER\npardoned O\nfour O\njournalists O\njailed O\nfor O\nthe O\nsame O\nor O\nsimilar O\noffences O\n. O\n\nThey O\nincluded O\none O\nof O\nthe O\nthree O\nLa B-ORG\nVoie I-ORG\njournalists O\n. O\n\nBedie B-PER\npardoned O\ntwo O\nother O\njournalists O\njailed O\nfor O\nincitement O\nto O\ndisturb O\npublic O\norder O\n. O\n\n-DOCSTART- O\n\nVillage O\nattack O\nkills O\n38 O\nin O\neastern O\nSierra B-LOC\nLeone I-LOC\n. O\n\nFREETOWN B-LOC\n1996-08-28 O\n\nSierra B-MISC\nLeonean I-MISC\nrebels O\nkilled O\n31 O\nvillagers O\nand O\nseven O\nsoldiers O\nin O\nan O\nattack O\non O\nthe O\neastern O\nvillage O\nof O\nFoindu B-LOC\n, O\nEastern B-ORG\nRegion I-ORG\nBrigade I-ORG\nCommander O\nMajor O\nFallah B-PER\nSewa I-PER\nsaid O\non O\nWednesday O\n. O\n\nSewa B-PER\nsaid O\nthe O\nrebels O\noverran O\nFoindu B-LOC\ndespite O\nthe O\npresence O\nof O\ngovernment O\ntroops O\nin O\nthe O\nvillage O\non O\nthe O\nhighway O\nbetween O\nMano B-LOC\nJunction I-LOC\nand O\nthe O\ndiamond O\ntown O\nof O\nTongo B-LOC\nField I-LOC\n. O\n\nAn O\narmy O\nspokesman O\nin O\nFreetown B-LOC\nsaid O\nMonday O\nnight O\n's O\nattack O\nwas O\nthe O\nthird O\non O\na O\nmilitary O\npost O\nin O\nthe O\npast O\nweek O\n. O\n\nRebels O\nof O\nthe O\nRevolutionary B-ORG\nUnited I-ORG\nFront I-ORG\nagreed O\na O\nceasefire O\nin O\nApril O\n. O\n\nContinuing O\nattacks O\nare O\ngenerally O\nascribed O\nto O\nrenegade O\nsoldiers O\nor O\nuncontrolled O\nbands O\nof O\nrebels O\nand O\nrefugees O\ndisplaced O\nby O\nthe O\nfighting O\nstarting O\nto O\nreturn O\nto O\ntheir O\nhomes O\n. O\n\nPeace O\ntalks O\nin O\nIvory B-LOC\nCoast I-LOC\nbegan O\nin O\nFebruary O\n. O\n\nDiplomats O\nsay O\nthey O\nare O\ndeadlocked O\nover O\nthe O\nRUF B-ORG\n's O\ninsistence O\nthat O\nforeign O\ntroops O\nhelping O\nthe O\ngovernment O\narmy O\nshould O\nleave O\n, O\nand O\nthat O\nthey O\nshould O\nhave O\nsome O\nsay O\nin O\nthe O\nallocation O\nof O\nbudget O\nspending O\n. O\n\n-DOCSTART- O\n\nAid O\nagency O\nsays O\nSudan B-LOC\nmissionaries O\nreleased O\n. O\n\nNAIROBI B-LOC\n1996-08-28 O\n\nAn O\naid O\nagency O\nsaid O\nsix O\nRoman B-MISC\nCatholic I-MISC\nmissionaries O\n, O\nincluding O\nthree O\nAustralian B-MISC\nnuns O\n, O\nwere O\nfreed O\nby O\nrebels O\nin O\nsouthern O\nSudan B-LOC\non O\nWednesday O\nafter O\nbeing O\nheld O\nfor O\nnearly O\ntwo O\nweeks O\n. O\n\nBut O\nCatholic B-MISC\nchurch O\nofficials O\nsaid O\nthey O\nhad O\nno O\nconfirmation O\nof O\nthe O\nreport O\nand O\nwould O\nhave O\nto O\nwait O\nuntil O\nThursday O\nto O\nbe O\nsure O\n. O\n\n-DOCSTART- O\n\nZambia B-LOC\n's O\nChiluba B-PER\nshuffles O\ncabinet O\nto O\nfill O\nvacancy O\n. O\n\nLUSAKA B-LOC\n1996-08-28 O\n\nZambian O\nPresident O\nFrederick B-PER\nChiluba I-PER\nshuffled O\nhis O\ncabinet O\non O\nWednesday O\nto O\nfill O\na O\nvacancy O\nleft O\nafter O\nthe O\nsacking O\nof O\nLegal O\nAffairs O\nMinister O\nRemmy B-PER\nMushota I-PER\n. O\n\nMushota B-PER\nwas O\nfired O\na O\nmonth O\nago O\nafter O\na O\ngovernment O\ntribunal O\nfound O\nhe O\ntried O\nto O\nwithdraw O\ncash O\nfrom O\nstate O\ncoffers O\nwithout O\nauthority O\n. O\n\nThe O\npresident O\n's O\noffice O\nsaid O\nin O\na O\nstatement O\nthat O\nLands O\nMinister O\nLuminzu B-PER\nShimaponda I-PER\nhad O\nbeen O\nappointed O\nLegal O\nAffairs O\nMinister O\n, O\nwhile O\nDeputy O\nForeign O\nMinister O\nPeter B-PER\nMachungwa I-PER\nwould O\ntake O\nover O\nfrom O\nShimaponda B-PER\n. O\n\n-DOCSTART- O\n\nGuinea B-LOC\nlaunches O\nwar O\non O\nfictitious O\ncivil O\nservants O\n. O\n\nCONAKRY B-LOC\n1996-08-28 O\n\nGuinea B-LOC\nlaunched O\na O\ndrive O\non O\nWednesday O\nto O\nrid O\nthe O\ncivil O\nservice O\npayroll O\nof O\nfictitious O\nworkers O\nas O\npart O\nof O\nnew O\nprime O\nminister O\nSidia B-PER\nToure I-PER\n's O\ncampaign O\nto O\ncut O\ngovernment O\nspending O\n. O\n\nDeputy O\nMinister O\nfor O\nFinance O\nOusmane B-PER\nKaba I-PER\nsaid O\nteams O\nof O\ninspectors O\nwould O\ncheck O\ngovernment O\noffices O\nin O\nthe O\ncapital O\nand O\nthe O\nprovinces O\nto O\nroot O\nout O\ncivil O\nservants O\nwho O\ndrew O\nsalaries O\nbut O\nhad O\nleft O\ntheir O\njobs O\n, O\nwere O\ndead O\n, O\nor O\nhad O\nnever O\nexisted O\n. O\n\nSome O\n50 O\nmillion O\nGuinean B-MISC\nfrancs O\n( O\n$ O\n50,000 O\n) O\nhas O\nbeen O\npumped O\ninto O\nthe O\nexercise O\nto O\ndeter O\nthe O\ninspectors O\nfrom O\ntaking O\nbribes O\n. O\n\nKaba B-PER\ntold O\nreporters O\nthe O\nannual O\nwage O\nbill O\nof O\n171 O\nbillion O\nGuinean B-MISC\nfrancs O\nrepresented O\n50 O\npercent O\nof O\ncurrent O\nstate O\nexpenditure O\n, O\n\" O\nwhereas O\nthe O\nacceptable O\nproportion O\nin O\ncountries O\nsimilar O\nto O\nours O\nis O\none O\nthird O\n\" O\n. O\n\nToure B-PER\n, O\nwho O\ntook O\noffice O\nlast O\nmonth O\n, O\nhas O\nsaid O\nhe O\nplans O\nto O\ncut O\npublic O\nservice O\nspending O\nby O\n30 O\npercent O\nby O\nthe O\nend O\nof O\nthe O\nyear O\nas O\npart O\nof O\nmeasures O\nto O\nrevive O\nthe O\neconomy O\n. O\n\nGuinea B-LOC\nis O\nrich O\nin O\nminerals O\nand O\nhas O\na O\nvast O\npotential O\nfor O\nhydroelectric O\npower O\ngeneration O\nbut O\nit O\nfaces O\nstiff O\ncompetition O\nfrom O\nits O\nWest B-MISC\nAfrican I-MISC\nneighbours O\nfor O\nforeign O\ninvestment O\n. O\n\nPresident O\nLansana B-PER\nConte I-PER\nappointed O\nToure B-PER\n, O\na O\nformer O\nsenior O\ncivil O\nservant O\nin O\nIvory B-LOC\nCoast I-LOC\n, O\nlast O\nmonth O\nto O\nclean O\nup O\nthe O\nadministration O\nand O\nreform O\nthe O\neconomy O\nfollowing O\nFebruary O\n's O\nbloody O\narmy O\nrevolt O\n. O\n\n( O\n$ O\n=1,000 O\nGuinean B-MISC\nfrancs O\n) O\n\n-DOCSTART- O\n\nNew O\nLiberia B-ORG\nCouncil I-ORG\nchief O\nto O\nbe O\ninstalled O\nTuesday O\n. O\n\nMONROVIA B-LOC\n1996-08-28 O\n\nRuth B-PER\nPerry I-PER\n, O\nthe O\nwoman O\nwith O\nthe O\ntask O\nof O\nuniting O\nLiberia B-LOC\n's O\nsquabbling O\nfactions O\naround O\nthe O\nlatest O\npeace O\nplan O\n, O\nwill O\nbe O\nformally O\ninstalled O\nas O\nhead O\nof O\nthe O\nruling O\nState B-ORG\nCouncil I-ORG\nnext O\nTuesday O\n, O\na O\nCouncil B-ORG\nstatement O\nsaid O\n. O\n\nPerry B-PER\n, O\na O\nLiberian B-MISC\nSenate B-ORG\nmember O\nduring O\nthe O\n1980s O\n, O\nreturned O\nto O\nMonrovia B-LOC\non O\nAugust O\n22 O\nafter O\nWest B-MISC\nAfrican I-MISC\nleaders O\nnominated O\nher O\nfor O\nthe O\njob O\nunder O\na O\npeace O\ndeal O\nsigned O\nin O\nNigeria B-LOC\n's O\ncapital O\nAbuja B-LOC\nfive O\ndays O\nearlier O\n. O\n\nThe O\nformal O\ninauguration O\nhad O\nbeen O\ndue O\nto O\ntake O\nplace O\nthis O\nweek O\nbut O\nwas O\nput O\nback O\n. O\n\nThere O\nwas O\nno O\nofficial O\nexplanation O\nbut O\npoliticians O\nsaid O\nfaction O\nleaders O\nand O\nState B-ORG\nCouncil I-ORG\nvice-chairmen O\nCharles B-PER\nTaylor I-PER\nand O\nAlhadji B-PER\nKromah I-PER\nwere O\nunable O\nto O\nattend O\nbecause O\nthey O\nwere O\ntravelling O\n. O\n\nLiberia B-LOC\n's O\ncivil O\nwar O\n, O\nlaunched O\nby O\nTaylor B-PER\nin O\n1989 O\n, O\nhas O\nkilled O\nwell O\nover O\n150,000 O\npeople O\n. O\n\nFaction O\nfighting O\nand O\nan O\norgy O\nof O\nlooting O\nin O\nthe O\ncapital O\nMonrovia B-LOC\nin O\nApril O\nand O\nMay O\nkilled O\nhundreds O\nof O\npeople O\n. O\n\nOver O\na O\ndozen O\npeace O\ndeals O\nhave O\ncollapsed O\n. O\n\nThe O\nlatest O\nsets O\na O\ntimetable O\nfor O\ndisarmament O\nby O\nthe O\nend O\nof O\nJanuary O\nand O\nelections O\nby O\nMay O\n30 O\n. O\n\nWest B-MISC\nAfrican I-MISC\nleaders O\nhave O\nthreatened O\nindividual O\nsanctions O\nagainst O\nfaction O\nleaders O\nto O\nensure O\ncompliance O\n. O\n\nFreed O\nAmerican B-MISC\nslaves O\nfounded O\nLiberia B-LOC\nin O\n1847 O\n. O\n\n-DOCSTART- O\n\nNigeria B-LOC\nrights O\ngroup O\nsays O\nfour O\nacademics O\narrested O\n. O\n\nLAGOS B-LOC\n1996-08-28 O\n\nA O\nNigerian B-MISC\nhuman O\nrights O\ngroup O\nsaid O\non O\nWednesday O\nthat O\nfour O\nmembers O\nof O\na O\nrecently O\nbanned O\nuniversity O\nunion O\nhad O\nbeen O\narrested O\n. O\n\n\" O\nThe O\nConstitutional B-ORG\nRights I-ORG\nProject I-ORG\n( O\nCRP B-ORG\n) O\nbelieves O\nthat O\nWilliam B-PER\nIstafanus I-PER\n, O\nElisha B-PER\nShamay I-PER\n, O\nO.K. B-PER\nLikkason I-PER\nand O\nJerome B-PER\nEgurugbe I-PER\nwere O\narrested O\nbecause O\nof O\ntheir O\nrole O\nin O\nthe O\nongoing O\nASUU B-ORG\n( O\nAcademic B-ORG\nStaff I-ORG\nUnion I-ORG\nof I-ORG\nUniversities I-ORG\n) O\nstrike O\n, O\n\" O\nthe O\ngroup O\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nCRP B-ORG\nsaid O\nthe O\nfour O\nwere O\narrested O\non O\nMonday O\nnight O\nat O\nthe O\nnortheastern O\nTafawa B-ORG\nBalewa I-ORG\nUniversity I-ORG\n. O\n\nThe O\nmain O\nacademic O\nunion O\n, O\nASUU B-ORG\n, O\nalong O\nwith O\ntwo O\nsmaller O\nuniversity O\nunions O\n, O\nwas O\nbanned O\nby O\nNigeria B-LOC\n's O\nmilitary O\ngovernment O\nlast O\nweek O\n, O\nbecause O\nof O\na O\nfour-month O\nstrike O\nby O\nteachers O\nfor O\nbetter O\nworking O\nconditions O\n. O\n\nNigeria B-LOC\nis O\nunder O\nfire O\nfrom O\nmany O\nWestern B-MISC\ncountries O\nfor O\nhuman O\nrights O\nabuses O\nand O\nlack O\nof O\ndemocracy O\n. O\n\nDozens O\nof O\npeople O\nopposed O\nto O\nthe O\ngovernment O\nare O\nin O\ndetention O\n. O\n\nCommonwealth B-ORG\nforeign O\nministers O\nare O\nto O\nmeet O\nin O\nLondon B-LOC\non O\nWednesday O\nto O\ndiscuss O\nwhat O\naction O\nto O\ntake O\n, O\nafter O\na O\nvisit O\nto O\nNigeria B-LOC\nwas O\ncalled O\noff O\nwhen O\nthe O\ngovernment O\nimposed O\nstrict O\nrules O\non O\nwhom O\nthe O\nmission O\nwould O\nbe O\nallowed O\nto O\nsee O\n. O\n\nNigeria B-LOC\nwas O\nsuspended O\nfrom O\nthe O\nclub O\nof O\nBritain B-LOC\nand O\nits O\nformer O\ncolonies O\nin O\nNovember O\nafter O\nthe O\nhanging O\nof O\nnine O\nminority O\nrights O\nactivists O\nfor O\nmurder O\nin O\nspite O\nof O\ninternational O\npleas O\nfor O\nclemency O\n. O\n\n-DOCSTART- O\n\nDutroux B-PER\nsuspected O\nin O\nmurder O\nof O\nSlovak B-MISC\nwoman O\n. O\n\nPeter B-PER\nLaca I-PER\n\nBRATISLAVA B-LOC\n1996-08-28 O\n\nMarc B-PER\nDutroux I-PER\n, O\nthe O\nchief O\naccused O\nin O\na O\nBelgian B-MISC\nchild O\nmurder O\nand O\nsex O\nabuse O\nscandal O\n, O\nis O\nsuspected O\nof O\nmurdering O\na O\nyoung O\nSlovak B-MISC\nwoman O\n, O\nthe O\nSlovak B-MISC\noffice O\nof O\nInterpol B-ORG\nsaid O\non O\nWednesday O\n. O\n\nRudolf B-PER\nGajdos I-PER\n, O\nhead O\nof O\nSlovak B-MISC\nInterpol B-ORG\n, O\ntold O\na O\nnews O\nconference O\nDutroux B-PER\nwas O\nalso O\nbelieved O\nto O\nhave O\nplanned O\nthe O\nkidnapping O\nof O\nat O\nleast O\none O\nSlovak B-MISC\nwoman O\n. O\n\n\" O\nOne O\nof O\nthe O\npolice O\nversions O\nin O\nthe O\ncase O\nof O\nthe O\nmurder O\nof O\nyoung O\ngypsy O\nwoman O\nin O\nTopolcany B-LOC\n, O\nwestern O\nSlovakia B-LOC\n, O\nthis O\nJuly O\n, O\nis O\na O\nsuspicion O\nthat O\nMark B-PER\nDutroux I-PER\ncould O\nhave O\nbeen O\ninvolved O\nin O\nthe O\nmurder O\n, O\n\" O\nGajdos B-PER\nsaid O\nwithout O\nelaborating O\non O\nthe O\nage O\nof O\nthe O\nvictim O\nand O\non O\nthe O\nother O\nversions O\n. O\n\nSlovak B-MISC\npolice O\n, O\nInterpol B-ORG\n, O\nand O\nBelgian B-MISC\npolice O\nhave O\nbeen O\nfollowing O\nleads O\non O\nDutroux B-PER\n's O\nactivities O\nin O\nSlovakia B-LOC\nand O\nthe O\nneighbouring O\nCzech B-LOC\nRepublic I-LOC\nwhere O\nhe O\nis O\nknown O\nto O\nhave O\nmade O\nfrequent O\nvisits O\n. O\n\nGajdos B-PER\nsaid O\nthe O\npolice O\nsketch O\nof O\nthe O\nsuspected O\nmurderer O\nwas O\n\" O\n60 O\npercent O\nidentical O\nwith O\nDutroux B-PER\n's O\nportrait O\n\" O\n, O\nand O\nthat O\nDutroux B-PER\nwas O\nknown O\nto O\nhave O\nbeen O\nin O\nTopolcany B-LOC\naround O\nthe O\ntime O\nof O\nthe O\nwoman O\n's O\nmurder O\n. O\n\n\" O\nTopolcany B-LOC\nand O\nthe O\narea O\naround O\nthis O\ntown O\nwere O\nreported O\nto O\nhave O\nbeen O\nthe O\nmost O\nvisited O\nplaces O\nby O\nDutroux B-PER\nand O\nhis O\naccomplices O\nin O\nSlovakia B-LOC\n, O\n\" O\nGajdos B-PER\nsaid O\n. O\n\nDutroux B-PER\n, O\na O\nconvicted O\nchild O\nrapist O\nand O\nunemployed O\nfather-of-three O\n, O\nled O\npolice O\n11 O\ndays O\nago O\nto O\nthe O\nbodies O\nof O\neight-year-olds O\nJulie B-PER\nLejeune I-PER\nand O\nMelissa B-PER\nRusso I-PER\nin O\nthe O\ngarden O\nof O\nanother O\nof O\nthe O\nsix O\nhouses O\nhe O\nowns O\naround O\nthe O\nsouthern O\nBelgian B-MISC\ncity O\nof O\nCharleroi B-LOC\n. O\n\n\" O\nThe O\nBelgian B-MISC\npolice O\nalso O\ninformed O\nus O\nthat O\nDutroux B-PER\n, O\ntogether O\nwith O\none O\nother O\nman O\n, O\nhad O\n( O\nalso O\n) O\nplanned O\nthe O\nkidnapping O\nof O\nat O\nleast O\none O\nSlovak B-MISC\nwoman O\n, O\n\" O\nGajdos B-PER\nsaid O\n. O\n\n\" O\nThe O\nplan O\napparently O\nfailed O\ndue O\nto O\ndifficulties O\nin O\ncrossing O\nthe O\nborder O\n, O\n\" O\nhe O\nadded O\n, O\nbut O\ndid O\nnot O\nelaborate O\n. O\n\nThe O\nSlovak B-MISC\npolice O\nare O\nalso O\ninvestigating O\nvisits O\nby O\nabout O\n10 O\nSlovak B-MISC\nwomen O\n, O\naged O\n17 O\nto O\n22 O\n, O\nto O\nBelgium B-LOC\n, O\nat O\nthe O\ninvitation O\nof O\nDutroux B-PER\n. O\n\nThe O\nwomen O\nsaid O\nthey O\nwent O\nto O\nBelgium B-LOC\nvoluntarily O\nand O\npolice O\nsuspect O\nthey O\nwere O\nused O\nto O\nact O\nin O\npornographic O\nfilms O\n, O\nGajdos B-PER\nsaid O\nearlier O\nthis O\nweek O\n. O\n\nBut O\nhe O\nadded O\nthey O\nhad O\ndifficulty O\nremembering O\nwhat O\nhappened O\nduring O\ntheir O\nvisits O\nto O\nBelgium B-LOC\n, O\nperhaps O\nbecause O\nof O\ndrugs O\n, O\nand O\nwere O\nunsure O\nwhether O\nthey O\nwere O\nfilmed O\nfor O\npornography O\n. O\n\nDutroux B-PER\n, O\n39 O\n, O\nwho O\nwas O\ncharged O\nlast O\nweek O\nwith O\nthe O\nabduction O\nand O\nillegal O\nimprisonment O\nof O\ntwo O\ngirls O\naged O\n14 O\nand O\n12 O\n, O\nis O\nalso O\nsuspected O\nin O\nthe O\ndisappearance O\nof O\nBelgians O\nAn B-PER\nMarchal I-PER\n, O\n19 O\n, O\nand O\nEefje B-PER\nLambrecks I-PER\n, O\n17 O\n, O\nwho O\nwent O\nmissing O\na O\nyear O\nago O\n. O\n\n-DOCSTART- O\n\nKnifeman O\nkills O\nPolish B-MISC\nbeauty O\nqueen O\n, O\nwounds O\nhusband O\n. O\n\nWARSAW B-LOC\n1996-08-28 O\n\nA O\nman O\nknifed O\nto O\ndeath O\ninternational O\nmodel O\nAgnieszka B-PER\nKotlarska I-PER\noutside O\nher O\nhome O\nin O\nWroclaw B-LOC\n, O\nwestern O\nPoland B-LOC\n, O\nPolish B-MISC\ntelevision O\nsaid O\non O\nWednesday O\n. O\n\nThe O\nman O\n, O\nwho O\nsaid O\nhe O\nhad O\nonce O\nbeen O\nengaged O\nto O\nher O\n, O\nfirst O\nknifed O\nKotlarska B-PER\n's O\nhusband O\nin O\nthe O\nleg O\n, O\nthen O\nstabbed O\nher O\nthree O\ntimes O\nin O\nthe O\nchest O\nwhen O\nshe O\ntried O\nto O\nintervene O\nduring O\nthe O\nincident O\non O\nTuesday O\n. O\n\nShe O\ndied O\nin O\nhospital O\n. O\n\nKotlarska B-PER\n, O\nwho O\nwas O\n24 O\nand O\nhad O\na O\nthree-year-old O\nchild O\n, O\nwas O\nMiss B-MISC\nPoland I-MISC\nin O\n1991 O\nand O\nwent O\non O\nto O\na O\nU.S.-based B-MISC\nmodelling O\ncareer O\nthat O\nincluded O\nworking O\nwith O\nItalian B-MISC\ndesigner O\nGianni B-PER\nVersace I-PER\nand O\nVogue B-ORG\nmagazine O\n, O\nthe O\nGazeta B-ORG\nWyborcza I-ORG\nnewspaper O\nsaid O\n. O\n\nShe O\nhad O\nbeen O\ndue O\nto O\nfly O\non O\na O\nTWA B-ORG\nairliner O\nwhich O\nexploded O\nnear O\nNew B-LOC\nYork I-LOC\nlast O\nmonth O\n, O\nbut O\nhad O\ncancelled O\nher O\nbooking O\n, O\nthe O\nnewspaper O\nsaid O\n. O\n\nHer O\nattacker O\n, O\nidentified O\nonly O\nas O\nJerzy B-PER\nL. I-PER\n, O\n36 O\n, O\nwas O\narrested O\nby O\npolice O\nand O\nwill O\nappear O\nin O\ncourt O\non O\nThursday O\nmorning O\n, O\ntelevision O\nreported O\n. O\n\nIt O\nsaid O\nhe O\nhad O\nadmitted O\nthe O\nattack O\nbut O\nhad O\ndenied O\nintending O\nto O\nkill O\nKotlarska B-PER\n. O\n\n-DOCSTART- O\n\nRussian B-MISC\nshares O\nslip O\nin O\nthin O\nvolume O\n. O\n\nMOSCOW B-LOC\n1996-08-28 O\n\nLeading O\nRussian B-MISC\nshares O\nedged O\ndown O\non O\nWednesday O\nin O\nthin O\nvolume O\nin O\nthe O\nabsence O\nof O\nWestern B-MISC\norders O\n, O\ntraders O\nsaid O\n. O\n\nThe O\nRussian B-MISC\nTrading I-MISC\nSystem I-MISC\nindex O\nof O\n21 O\nissues O\nfell O\n1.64 O\npercent O\nto O\n180.38 O\non O\nvolume O\nof O\n$ O\n4.38 O\nmillion O\n. O\n\n\" O\nThe O\nmarket O\nwas O\nextremely O\nquiet O\ntoday O\n, O\nsome O\nprofit-taking O\nlocally O\n, O\nno O\nWestern B-MISC\norders O\n, O\n\" O\nsaid O\nNick B-PER\nMokhoff I-PER\n, O\ndirector O\nof O\nsales O\nand O\ntrade O\nat O\nAlliance-Menatep B-ORG\n. O\n\" O\n\nWe O\nare O\njust O\na O\nbit O\nlower O\nwith O\na O\nlot O\nof O\ninactivity O\nduring O\nthe O\nwhole O\nday O\n. O\n\" O\n\nAlexander B-PER\nBabayan I-PER\n, O\nmanaging O\ndirector O\nat O\nCentrInvest B-ORG\nSecurities I-ORG\n, O\nsaid O\nthe O\nvolume O\nof O\norders O\nwas O\nfour O\nto O\nfive O\ntimes O\nlower O\nthan O\na O\nweek O\nago O\n. O\n\nAs O\noften O\n, O\nthe O\nmost O\nvolume O\nwas O\nin O\nUES B-ORG\n. O\n\n\" O\nUnified O\nis O\none O\nof O\nthe O\nblue O\nchips O\n, O\nwhich O\nhas O\nmore O\nprospects O\nthan O\nanybody O\nelse O\ndoes O\n, O\nbecause O\nthey O\nhave O\nADRs B-MISC\nsupposedly O\ncoming O\nup O\n, O\n\" O\nMokhoff B-PER\nsaid O\n. O\n\nUES B-ORG\nofficials O\nsaid O\nlast O\nweek O\nthe O\nboard O\nhad O\nnot O\nyet O\napproved O\nthe O\nfinal O\nversion O\nof O\nits O\napplication O\nto O\nthe O\nU.S. B-ORG\nSecurities I-ORG\nand I-ORG\nExchange I-ORG\nCommission I-ORG\nto O\nissue O\nADRs B-MISC\n. O\n\nUES B-ORG\nfell O\nto O\n$ O\n0.0817 O\nfrom O\n$ O\n0.0822 O\nat O\nTuesday O\n's O\nclose O\nwith O\n8.90 O\nmillion O\nshares O\nchanging O\nhands O\n. O\n\nGazprom B-ORG\nwas O\nthe O\nloser O\nof O\nthe O\nday O\nwith O\nprices O\nclosing O\nat O\n$ O\n0.300 O\n, O\ndown O\nfrom O\n$ O\n0.355 O\non O\nTuesday O\nand O\n$ O\n0.445 O\non O\nMonday O\n. O\n\nMokhoff B-PER\nsaid O\nuncertainty O\nabout O\nwhen O\nGazprom B-ORG\nwould O\nissue O\nADRs B-MISC\nand O\nabout O\nwhether O\nshares O\nfrom O\nthe O\nRussian B-MISC\nmarket O\ncould O\nbe O\nconverted O\ninto O\nADRs B-MISC\nhad O\nhurt O\nprices O\n. O\n\n\" O\nWestern B-MISC\ninvestors O\n... O\nwill O\nbe O\ninvesting O\nin O\nADRs B-MISC\nand O\nI O\ndo O\nnot O\nthink O\npeople O\nin O\nRussia B-LOC\nwill O\nbe O\nable O\nto O\ncome O\nup O\nwith O\nthe O\nmoney O\nfor O\nthe O\nunderlying O\nshares O\nto O\ndrive O\nthe O\nRussian B-MISC\nshares O\nto O\nthose O\nlevels O\n, O\n\" O\nMokhoff B-PER\nsaid O\n. O\n\nGazprom B-ORG\nhas O\nalso O\ntightened O\nthe O\nrules O\nrestricting O\nshareholers O\n' O\nrights O\nto O\ntrade O\nits O\nshares O\n. O\n\nMosenergo B-ORG\nclosed O\nat O\nat O\n$ O\n0.958 O\nafter O\n$ O\n0.966 O\n, O\nRostelekom B-ORG\nfell O\nto O\n$ O\n2.56 O\nfrom O\n$ O\n2.58 O\nand O\nLUKoil B-ORG\nwas O\n$ O\n9.82 O\nafter O\n$ O\n9.85 O\n. O\n\n-- O\nJulie B-PER\nTolkacheva I-PER\n, O\nMoscow B-ORG\nNewsroom I-ORG\n, O\n+7095 O\n941 O\n8520 O\n\n-DOCSTART- O\n\nAlbania B-LOC\nasks O\nGreece B-LOC\nto O\nexplain O\ndeportations O\n. O\n\nTIRANA B-LOC\n1996-08-28 O\n\nAlbania B-LOC\nasked O\nGreece B-LOC\non O\nWednesday O\nto O\nexplain O\nwhy O\nit O\nwas O\ndeporting O\nmore O\nAlbanian B-MISC\nimmigrants O\n, O\nForeign O\nMinister O\nTritan B-PER\nShehu I-PER\nsaid O\n. O\n\nThe O\nAlbanian B-MISC\ndaily O\nKoha B-ORG\nJone I-ORG\nreported O\nearlier O\nthat O\nGreece B-LOC\nhad O\ndeported O\nabout O\n5,000 O\nAlbanians B-MISC\nin O\nthe O\nlast O\nfive O\ndays O\n. O\n\n\" O\nThe O\nForeign B-ORG\nMinistry I-ORG\nis O\ntrying O\nto O\nfind O\nout O\nfrom O\nthe O\nGreek B-MISC\nembassy O\nwhy O\nAlbanian B-MISC\nrefugees O\nhave O\nbeen O\ndeported O\nfrom O\nGreece B-LOC\n, O\n\" O\nShehu B-PER\ntold O\nReuters B-ORG\n. O\n\nAthens B-LOC\nand O\nTirana B-LOC\nsigned O\nan O\naccord O\nin O\nMay O\nto O\nlegalise O\nthe O\nstatus O\nof O\nAlbanian B-MISC\nimmigrant O\nworkers O\n, O\nestimated O\nat O\n350,000 O\n, O\nand O\nremove O\na O\nlong-standing O\nstumbling O\nblock O\nin O\nrelations O\nbetween O\nthe O\ntwo O\nBalkan B-LOC\nneighbours O\n. O\n\n-DOCSTART- O\n\nBulgarians B-MISC\nrecover O\n75 O\npct O\nof O\nconfiscated O\nland O\n. O\n\nSOFIA B-LOC\n1996-08-28 O\n\nBulgaria B-LOC\nhas O\nrestored O\nownership O\nrights O\nto O\npre-communist O\nprivate O\nowners O\nof O\n75 O\npercent O\nof O\nthe O\narable O\nland O\nor O\naround O\nfour O\nmillion O\nhectares O\n, O\nan O\nAgriculture B-ORG\nMinistry I-ORG\nofficial O\nsaid O\non O\nWednesday O\n. O\n\n\" O\nSo O\nfar O\n75 O\npercent O\nhas O\nbeen O\nreturned O\nwith O\nthe O\nland O\nrestitution O\nalmost O\ncompleted O\nin O\nsome O\nregions O\nlike O\nSoutheastern B-LOC\nBulgaria I-LOC\nbut O\nlagging O\nbehind O\nin O\nother O\nareas O\n, O\npredominantly O\nin O\nthe O\nmountains O\n, O\n\" O\nthe O\nofficial O\ntold O\na O\nnews O\nconference O\n. O\n\nThe O\nministry O\nhas O\nsaid O\nthat O\nit O\nplanned O\nto O\nreturn O\n96.6 O\npercent O\nof O\nthe O\narable O\nland O\nor O\n5.2 O\nmillion O\nhectares O\nto O\nits O\noriginal O\nowners O\nby O\nthe O\nend O\nof O\nthis O\nyear O\n. O\n\nA O\nland O\nreform O\nact O\npassed O\nfour O\nyears O\nago O\nabolished O\nSoviet-style B-MISC\ncollective O\nfarms O\n, O\nallowing O\nthe O\nreturn O\nof O\n5.4 O\nmillion O\nhectares O\nto O\noriginal O\nowners O\nor O\ntheir O\nheirs O\n. O\n\n-- O\nSofia B-ORG\nNewsroom I-ORG\n, O\n( O\n++359-2 O\n) O\n981 O\n8569 O\n\n-DOCSTART- O\n\nGerman B-MISC\nchancellor O\nto O\nmeet O\nYeltsin B-PER\nSept O\n7 O\n- O\nInterfax B-ORG\n. O\n\nMOSCOW B-LOC\n1996-08-28 O\n\nGerman B-MISC\nChancellor O\nHelmut B-PER\nKohl I-PER\n, O\nwho O\nspoke O\nto O\nPresident O\nBoris B-PER\nYeltsin I-PER\nby O\ntelephone O\non O\nWednesday O\n, O\nplans O\na O\ntrip O\nto O\nMoscow B-LOC\non O\nSeptember O\n7 O\nand O\nwill O\nvisit O\nYeltsin B-PER\nat O\nhis O\nvacation O\nhome O\nnear O\nMoscow B-LOC\n, O\nInterfax B-ORG\nnews O\nagency O\nsaid O\n. O\n\nInterfax B-ORG\n, O\nquoting O\nYeltsin B-PER\npress O\nsecretary O\nSergei B-PER\nYastrzhembsky I-PER\n, O\nsaid O\nYeltsin B-PER\nand O\nKohl B-PER\nhad O\ndiscussed O\nbilateral O\nrelations O\nand O\ninternational O\nissues O\non O\nthe O\ntelephone O\n. O\n\nYeltsin B-PER\nhad O\ntold O\nKohl B-PER\nabout O\nefforts O\nto O\nfind O\na O\npolitical O\nsolution O\nto O\nthe O\nconflict O\nin O\nRussia B-LOC\n's O\nbreakaway O\nChechnya B-LOC\nregion O\n, O\nInterfax B-ORG\nadded O\n. O\n\nYeltsin B-PER\n, O\nwho O\nleft O\non O\nvacation O\non O\nMonday O\n, O\nis O\nstaying O\nat O\nan O\nexclusive O\nprivate O\nhunting O\nlodge O\nsome O\n100 O\nkm O\n( O\n60 O\nmiles O\n) O\nfrom O\nMoscow B-LOC\n. O\n\nGermany B-LOC\nhas O\nbeen O\none O\nof O\nthe O\nloudest O\ncritics O\nof O\nRussia B-LOC\n's O\nmilitary O\nintervention O\nin O\nChechnya B-LOC\n, O\na O\n20-month-old O\nconflict O\nin O\nwhich O\ntens O\nof O\nthousands O\nof O\npeople O\nhave O\nbeen O\nkilled O\n. O\n\n-DOCSTART- O\n\nExiled O\nBosnians B-MISC\nprotest O\nconfusing O\nvoting O\nrules O\n. O\n\nDuncan B-PER\nShiels I-PER\n\nNAGYATAD B-LOC\n, O\nHungary B-LOC\n1996-08-28 O\n\nBosnian B-MISC\nrefugees O\nin O\nHungary B-LOC\n, O\nthe O\nfirst O\nto O\nvote O\nlast O\nweekend O\nin O\ntheir O\ncountry O\n's O\nfirst O\npost-war O\nelection O\n, O\nfound O\nthe O\nrules O\nconfusing O\nand O\nsome O\nhad O\nno O\nidea O\nwho O\nthey O\nvoted O\nfor O\n, O\nrefugees O\nand O\nofficials O\nsaid O\non O\nWednesday O\n. O\n\n\" O\nFor O\nthe O\nmost O\npart O\nthey O\nreally O\ndid O\nn't O\nunderstand O\nwhat O\nwas O\ngoing O\non O\n, O\n\" O\nthe O\ndirector O\nof O\nthe O\nNagyatad B-LOC\ncamp O\nLajos B-PER\nHorvath I-PER\ntold O\nReuters B-ORG\non O\nWednesday O\n. O\n\n\" O\nIt O\nwas O\nconfusing O\n, O\nthey O\nhad O\nno O\nexperience O\nof O\nvoting O\n, O\nmany O\nof O\nthe O\nrefugees O\nare O\nonly O\nsemi-literate O\nand O\nnone O\nof O\nthem O\nknew O\nanything O\nabout O\nthe O\ncandidates O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nThey O\njust O\nvoted O\nalong O\nethnic O\nlines O\nwhere O\nthey O\ncould O\n. O\n\" O\n\nThe O\nBosnian B-MISC\nelection O\nis O\nset O\nfor O\nSeptember O\n14 O\nand O\nvoting O\nbegan O\non O\nWednesday O\nfor O\nmost O\nof O\nthe O\n600,000 O\nBosnians B-MISC\nliving O\nabroad O\n. O\n\nThe O\nOrganisation B-ORG\nfor I-ORG\nSecurity I-ORG\nand I-ORG\nCooperation I-ORG\nin I-ORG\nEurope I-ORG\n, O\nwhich O\nis O\nrunning O\nthe O\nelection O\n, O\nallowed O\nthe O\nballot O\nto O\nbe O\nheld O\non O\nSunday O\nin O\nfour O\nHungarian B-MISC\nrefugee O\ncamps O\n. O\n\nSome O\nMoslem B-MISC\nrefugees O\namong O\nthe O\n385 O\nregistered O\nvoters O\nHungary B-LOC\n's O\nlargest O\ncamp O\nNagyatad B-LOC\nhave O\nwritten O\nto O\nthe O\nOSCE B-ORG\ncomplaining O\nthat O\nthey O\nwere O\nunable O\nto O\nvote O\nin O\ncontests O\nfor O\nthe O\npresident O\nor O\nassembly O\nof O\nthe O\nBosnian-Croat B-LOC\nFederation I-LOC\n, O\nwhere O\nmost O\nMoslems B-MISC\nlive O\n. O\n\nThis O\nwas O\nbecause O\ntheir O\npre-war O\nhomes O\nare O\nnow O\nin O\nthe O\nSerb-controlled B-MISC\nterritory O\n, O\nso O\nthey O\nwere O\nvoting O\nfor O\nthe O\nnational O\nassembly O\nof O\nthe O\nRepublika B-LOC\nSrbska I-LOC\n, O\nmost O\nof O\nthe O\ncandidates O\nfor O\nwhich O\nare O\nSerbs B-MISC\n. O\n\nFor O\nthe O\nforeign O\npowers O\nwhich O\nback O\nlast O\nyear O\n's O\nDayton B-LOC\npeace O\nagreement O\n, O\nthe O\nmain O\npoint O\nof O\nthe O\nelection O\nrules O\nis O\nthat O\nby O\nvoting O\nas O\nthough O\nthey O\nwere O\nstill O\nin O\ntheir O\npre-war O\nhomes O\n, O\nBosnians B-MISC\nshould O\noverride O\nthe O\neffects O\nof O\nethnic O\ncleansing O\nand O\nreassert O\nthe O\nconcept O\nof O\na O\nsingle O\nmulti-ethnic O\nstate O\n. O\n\nBut O\nAdem B-PER\nHodzic I-PER\n, O\none O\nof O\nthe O\nrefugees O\nwho O\nsigned O\nthe O\nletter O\nof O\ncomplaint O\n, O\ntold O\nReuters B-ORG\n: O\n\n\" O\nWe O\nonly O\nrealised O\nafter O\nvoting O\nthat O\nwe O\nwere O\nbeing O\ndenied O\nthe O\nrights O\nof O\nother O\nBosnian B-MISC\nMoslems I-MISC\nto O\nchoose O\nour O\npresident O\n. O\n\nThis O\nvote O\nseals O\nthe O\ndivision O\nof O\nmy O\ncountry O\n. O\n\" O\n\nUnder O\nthe O\nelection O\nrules O\ncitizens O\nvote O\nfor O\na O\nthree-man O\npresidency O\nand O\nHouse B-ORG\nof I-ORG\nRepresentatives I-ORG\nfor O\nall O\nBosnia-Hercegovina B-LOC\nand O\nfor O\nassemblies O\nand O\ncantonal O\nseats O\nin O\neither O\nthe O\nMoslem-Croat B-LOC\nFederation I-LOC\nor O\nthe O\nRepublika B-LOC\nSrbska I-LOC\n. O\n\nOn O\nSunday O\nvoters O\nin O\nHungary B-LOC\nalso O\ncast O\nballots O\nfor O\nmunicipal O\ncouncils O\nbut O\nthese O\nwill O\nbe O\ninvalidated O\nfollowing O\nthe O\ncancellation O\nof O\nlocal O\nelections O\nby O\nthe O\nOSCE B-ORG\non O\nTuesday O\n. O\n\nHusein B-PER\nMicijevic I-PER\n, O\nwho O\nalso O\nsigned O\nthe O\nletter O\n, O\nalleged O\nthat O\nelderly O\nvoters O\nwere O\ndirected O\nwho O\nto O\nvote O\nfor O\nby O\nHungarian B-MISC\ntranslators O\nwho O\nstood O\nin O\nthe O\npolling O\nbooth O\nto O\nhelp O\nthem O\n. O\n\n\" O\nProbably O\n100 O\nrefugees O\nwere O\nshown O\nwhere O\nto O\nput O\ntheir O\ncross O\n, O\n\" O\nhe O\nsaid O\n. O\n\nSeventy O\neight-year-old O\nMandolina B-PER\nZelic I-PER\n, O\na O\nBosnian B-MISC\nCroat I-MISC\nwho O\nhas O\nspent O\nthe O\nlast O\nfive O\nyears O\nin O\nNagyatad B-LOC\n, O\ntold O\nReuters B-ORG\nshe O\nhad O\ncast O\nher O\nballot O\nbecause O\nshe O\n'd O\nbeen O\ntold O\nto O\nby O\nthe O\ncamp O\nauthorities O\nbut O\nhad O\nno O\nidea O\nwho O\nshe O\nvoted O\nfor O\n. O\n\n\" O\nAt O\nfirst O\nthe O\norganisers O\nwould O\nn't O\nlet O\nanyone O\nhelp O\nme O\nbut O\nwhen O\nthey O\nsaw O\nI O\ndid O\nn't O\nunderstand O\na O\nyoung O\ntranslator O\nringed O\nthe O\nnames O\nI O\nhad O\nto O\nmark O\n, O\n\" O\nshe O\nsaid O\n. O\n\" O\n\nI O\ndo O\nn't O\nknow O\nwho O\nI O\nvoted O\nfor O\n. O\n\" O\n\nMaria B-PER\nSzabo I-PER\nof O\nthe O\nHungarian B-MISC\noffice O\norganising O\nthe O\nelections O\non O\nbehalf O\nof O\nthe O\nOSCE B-ORG\ntold O\nReuters B-ORG\non O\nWednesday O\nher O\noffice O\nwas O\nstudying O\nthe O\nletter O\nbut O\nsaid O\nthey O\nhad O\nfollowed O\nOSCE B-ORG\ninstructions O\nvery O\ncarefully O\n. O\n\n\" O\nThe O\nenvelopes O\n, O\neach O\nwith O\nthe O\nfive O\ndifferent O\nvoting O\nslips O\n, O\nwere O\nsealed O\nuntil O\nvoting O\nand O\nhad O\nwritten O\ninstructions O\non O\nhow O\nto O\nvote O\n, O\n\" O\nshe O\nsaid O\n. O\n\" O\n\nBut O\nof O\ncourse O\nthose O\nwho O\ncould O\nnot O\nread O\nhad O\nto O\nbe O\nshown O\n. O\n\" O\n\n-DOCSTART- O\n\nEstonia B-LOC\npresidential O\nrace O\nnext O\nround O\non O\nSept O\n20 O\n. O\n\nTALLINN B-LOC\n1996-08-28 O\n\nEstonia B-LOC\nwill O\nhold O\nthe O\nnext O\nround O\nof O\nan O\ninconclusive O\nstate O\npresidential O\nrace O\non O\nSeptember O\n20 O\n, O\nparliamentary O\nofficers O\nof O\nthe O\nBaltic B-MISC\nstate O\nruled O\non O\nWednesday O\n. O\n\nThis O\ncomes O\nafter O\nthree O\nvotes O\nin O\nthe O\n101-strong O\nparliament O\non O\nMonday O\nand O\nTuesday O\nfailed O\nto O\ngive O\neither O\nincumbent O\nLennart B-PER\nMeri I-PER\nor O\nrival O\ncandidate O\nArnold B-PER\nRuutel I-PER\nthe O\nnecessary O\n68 O\nvotes O\nfor O\na O\nclear O\nmandate O\n. O\n\nThe O\noutcome O\nwas O\na O\nrebuff O\nfor O\nMeri B-PER\n, O\nfailing O\nthree O\ntimes O\nto O\nwin O\nbacking O\nin O\nhis O\nbid O\nfor O\na O\nsecond O\nterm O\nas O\nhead O\nof O\nstate O\nof O\nthe O\nformer O\nSoviet B-MISC\nrepublic O\n. O\n\nParliament O\n's O\npress O\nofficer O\ntold O\nReuters B-ORG\nthat O\nSpeaker O\nToomas B-PER\nSavi I-PER\nwill O\nconvene O\nan O\nelectoral O\ncollege O\ninvolving O\n101 O\nMPs O\nand O\nand O\n273 O\nlocal O\ngovernment O\nrepresentatives O\non O\nSeptember O\n20 O\n. O\n\nBoth O\nMeri B-PER\n, O\n67 O\n, O\nand O\nRuutel B-PER\n, O\n68 O\nwill O\nautomatically O\nbe O\nlisted O\nas O\ncandidates O\nbut O\nthe O\nelection O\nwill O\nalso O\nbe O\nopen O\nto O\nnew O\nnominations O\nwith O\nthe O\nbacking O\nof O\nany O\n21 O\nmembers O\nof O\nthe O\ncollege O\n. O\n\nThe O\nwinner O\nhas O\nto O\nsecure O\na O\nmajority O\nfrom O\nthe O\ncollege O\nwithin O\ntwo O\nrounds O\nof O\nvoting O\notherwise O\nthe O\nelection O\nwill O\ngo O\nback O\nbefore O\nthe O\nparliament O\n. O\n\n-DOCSTART- O\n\nLebed B-PER\nlikely O\nto O\nfail O\non O\nChechnya B-LOC\n- O\nPolish B-MISC\nminister O\n. O\n\nWARSAW B-LOC\n1996-08-28 O\n\nRussian B-MISC\nsecurity O\nchief O\nAleksander B-PER\nLebed I-PER\nfaces O\nan O\nalmost O\nimpossible O\ntask O\nin O\nChechnya B-LOC\nand O\nis O\nlikely O\nto O\nbe O\nsidelined O\n, O\nPolish B-MISC\nForeign O\nMinister O\nDariusz B-PER\nRosati I-PER\nwas O\nreported O\nas O\nsaying O\non O\nWednesday O\n. O\n\nAccording O\nto O\nbest-selling O\ndaily O\nGazeta B-ORG\nWyborcza I-ORG\n, O\nRosati B-PER\ntold O\nthe O\nPolish B-MISC\nparliament O\n's O\nforeign O\naffairs O\ncommittee O\non O\nTuesday O\nthat O\nthe O\nfact O\nLebed B-PER\nhad O\nbeen O\ncharged O\nwith O\nresolving O\nthe O\nconflict O\nin O\nChechnya B-LOC\nshowed O\nhe O\nwould O\nbe O\nmarginalised O\n. O\n\n\" O\nIt O\nis O\nalmost O\nimpossible O\nto O\ngain O\nsuccess O\nin O\nthis O\n, O\n\" O\nit O\nquoted O\nRosati B-PER\nas O\nsaying O\nduring O\na O\ncommittee O\ndebate O\n. O\n\n\" O\nLebed B-PER\nhas O\nno O\ndiplomatic O\nexperience O\n. O\n\nYeltsin B-PER\nsent O\nhim O\nthere O\nto O\ncompromise O\nhim O\n. O\n\nThis O\ntactical O\nmanoeuvre O\nalso O\nshows O\nthat O\nin O\nthe O\nruling O\ncircle O\nthere O\nis O\nno O\nunity O\nof O\naction O\n, O\n\" O\nhe O\nsaid O\n. O\n\nLebed B-PER\n, O\nwho O\nhas O\narranged O\na O\nmilitary O\ntruce O\nwith O\nseparatist O\nrebels O\nin O\nthe O\nsouthern O\nRussia B-LOC\nregion O\n, O\nwas O\nin O\nMoscow B-LOC\nthis O\nweek O\nseeking O\nsupport O\nfor O\na O\ndeal O\non O\nChechnya B-LOC\n's O\npolitical O\nstatus O\n. O\n\nBut O\nRussian B-MISC\nPresident O\nBoris B-PER\nYeltsin I-PER\nhas O\nseemed O\nunwilling O\nto O\nmeet O\nhis O\nenvoy O\nand O\nwent O\non O\nholiday O\non O\nMonday O\n. O\n\nGazeta B-ORG\nWyborcza I-ORG\nquoted O\nRosati B-PER\nas O\nsaying O\nYeltsin B-PER\nwas O\nvery O\nill O\nand O\neffectively O\non O\nleave O\n, O\nbut O\nfor O\nnow O\nretained O\ncontrol O\nin O\nRussia B-LOC\nalthough O\nmatters O\nwere O\npassing O\ninto O\nthe O\nhands O\nof O\nhis O\nclose O\ncollaborators O\n. O\n\nRosati B-PER\nsaid O\nRussia B-LOC\n's O\nJuly O\npolls O\n, O\nin O\nwhich O\nYeltsin B-PER\nwon O\nre-election O\n, O\nshowed O\ndemocracy O\nhad O\npassed O\nan O\nimportant O\ntest O\nand O\nthe O\nRussian B-MISC\npeople O\nhad O\nchosed O\nthe O\npath O\nof O\nfurther O\nreforms O\n. O\n\nBut O\nhe O\nsaid O\na O\npower O\nstruggle O\nin O\nRussia B-LOC\n's O\nruling O\ncircles O\ncould O\nnot O\nbe O\nruled O\nout O\n, O\nwhich O\ncould O\nharm O\nfurther O\nreforms O\n. O\n\nHe O\nexpressed O\nconcern O\nover O\nproblems O\nin O\nthe O\nRussian B-MISC\neconomy O\n, O\nsaying O\nthis O\ncould O\nlead O\nto O\nsocial O\nunrest O\n, O\nthe O\ndaily O\nreported O\n. O\n\nOn O\nMoscow B-LOC\n's O\nforeign O\npolicy O\n, O\nRosati B-PER\nsaid O\nit O\nhad O\nchanged O\nits O\nstance O\non O\nNATO B-ORG\n's O\neastward O\nexpansion O\nand O\nwas O\npreparing O\nitself O\nfor O\nPoland B-LOC\n's O\ninevitable O\nentry O\ninto O\nthe O\nWestern B-MISC\nalliance O\n. O\n\nHe O\nalso O\nreportedly O\ncriticised O\nRussian B-MISC\nForeign O\nMinister O\nYevgeny B-PER\nPrimakov I-PER\n, O\nsaying O\nhis O\nstyle O\nof O\nwork O\nresembled O\nthat O\nof O\nthe O\nSoviet-era B-MISC\n1970s O\nand O\n1980s O\n. O\n\n-DOCSTART- O\n\nRomania B-LOC\nstate O\nbudget O\nsoars O\nin O\nJune O\n. O\n\nBUCHAREST B-LOC\n1996-08-28 O\n\nRomania B-LOC\n's O\nstate O\nbudget O\ndeficit O\njumped O\nsharply O\nin O\nJune O\nto O\n1,242.9 O\nbillion O\nlei O\nfor O\nthe O\nJanuary-June O\nperiod O\nfrom O\n596.5 O\nbillion O\nlei O\nin O\nJanuary-May O\n, O\nofficial O\ndata O\nshowed O\non O\nWednesday O\n. O\n\nSix-month O\nexpenditures O\nstood O\nat O\n9.50 O\ntrillion O\nlei O\n, O\nup O\nfrom O\n7.56 O\ntrillion O\nlei O\nat O\nend-May O\n, O\nwith O\neducation O\nand O\nhealth O\nspending O\naccounting O\nfor O\n31.6 O\npercent O\nof O\nstate O\nexpenses O\nand O\neconomic O\nsubsidies O\nand O\nsupport O\ntaking O\nsome O\n26 O\npercent O\n. O\n\nJanuary-June O\nrevenues O\nwent O\nup O\nto O\n8.26 O\ntrillion O\nlei O\nfrom O\n6.96 O\ntrillion O\nlei O\nin O\nthe O\nfirst O\nfive O\nmonths O\nthis O\nyear O\n. O\n\nRomania B-LOC\n's O\ngovernment O\nis O\nexpected O\nto O\nrevise O\nthe O\n1996 O\nbudget O\non O\nWednesday O\nto O\nbring O\nit O\ninto O\nline O\nwith O\nhigher O\ninflation O\n, O\nnew O\nwage O\nand O\npension O\nindexations O\nand O\ncosts O\nof O\nenergy O\nimports O\nthat O\nhave O\npushed O\nup O\nthe O\nstate O\ndeficit O\n. O\n\nUnder O\nthe O\nrevised O\nversion O\nstate O\nspending O\nis O\nexpected O\nto O\nrise O\nby O\nsome O\n566 O\nbillion O\nlei O\n. O\n\nNo O\nnew O\ndeficit O\nforecast O\nhas O\nbeen O\nissued O\nso O\nfar O\n. O\n\nIn O\nJuly O\nthe O\ngovernment O\ngave O\na O\n6.0-percent O\nwage O\nand O\npension O\nindexation O\nto O\ncover O\nenergy O\n, O\nfuel O\nand O\nbread O\nprice O\nincreases O\n, O\nwhich O\nquickened O\ninflation O\nto O\n7.5 O\npercent O\nlast O\nmonth O\n. O\n\nIn O\nthe O\noriginal O\nstate O\nbudget O\n, O\napproved O\nin O\nMarch O\n, O\nrevenues O\nwere O\nenvisaged O\nat O\naround O\n16.98 O\ntrillion O\nlei O\nand O\nexpenditures O\n20.17 O\ntrillion O\nlei O\nfor O\n1996 O\n. O\n\nThe O\nstate O\nbudget O\ndeficit O\nwas O\noriginally O\nforecast O\nto O\nbe O\n3.19 O\ntrillion O\nlei O\nfor O\nthe O\nwhole O\nyear O\n. O\n\nOn O\nWednesday O\n, O\nthe O\nleu O\n's O\nofficial O\nrate O\nwas O\n3,161 O\nto O\nthe O\ndollar O\n. O\n\n-- O\nBucharest B-ORG\nNewsroom I-ORG\n40-1 O\n3120264 O\n\n-DOCSTART- O\n\nCosta B-LOC\nRica I-LOC\nsays O\nDutch B-MISC\npair O\nkidnapped O\nby O\nNicaraguans B-MISC\n. O\n\nSAN B-LOC\nJOSE I-LOC\n, O\nCosta B-LOC\nRica I-LOC\n1996-08-28 O\n\nThe O\nCosta B-MISC\nRican I-MISC\ngovernment O\nsaid O\non O\nWednesday O\nthat O\na O\nDutch B-MISC\ncouple O\nabducted O\nover O\nthe O\nweekend O\nfrom O\na O\ntree O\nfarm O\nin O\nnorthern O\nCosta B-LOC\nRica I-LOC\nwas O\nkidnapped O\nby O\nformer O\nNicaraguan B-MISC\nguerrillas O\n. O\n\n\" O\nEven O\nthough O\nit O\n's O\nan O\nact O\nof O\ncommon O\ndelinquency O\n, O\nthe O\ncase O\ncould O\ntake O\na O\ndifficult O\nturn O\nbecause O\nformer O\nNicaraguan B-MISC\nguerrillas O\nare O\ninvolved O\n, O\n\" O\nSecurity O\nMinister O\nBernardo B-PER\nArce I-PER\ntold O\nreporters O\n. O\n\nEarlier O\nthis O\nyear O\n, O\na O\nGerman B-MISC\ntourist O\nand O\na O\nSwiss B-MISC\ntour O\nguide O\nwere O\nkidnapped O\nfrom O\nthe O\nsame O\ngeneral O\narea O\nin O\nnorthern O\nCosta B-LOC\nRica I-LOC\nnear O\nthe O\nNicaraguan B-MISC\nborder O\n. O\n\nThey O\nwere O\nheld O\nfor O\n71 O\ndays O\nbefore O\nrelatives O\npaid O\na O\nransom O\nto O\nfree O\nthem O\n. O\n\nTwo O\nNicaraguan B-MISC\nformer O\nguerrillas O\nhave O\nbeen O\narrested O\nin O\nthe O\ncase O\n. O\n\nBecause O\nof O\nthe O\napparent O\nthreat O\nto O\nforeigners O\nin O\nCosta B-LOC\nRica I-LOC\nnear O\nthe O\nNicaraguan B-MISC\nborder O\n, O\nArce B-PER\nsaid O\nthe O\ngovernment O\nhas O\nadvised O\nmany O\nto O\ntake O\nadditional O\nsecurity O\nmeasures O\non O\ntheir O\nown O\n. O\n\nHurte B-PER\nSierd I-PER\nZylstra I-PER\nand O\nhis O\nwife O\n, O\nJetsi B-PER\nHendrika I-PER\nCoers I-PER\n, O\nboth O\n50 O\nyears O\nold O\n, O\nwere O\nseized O\nlate O\non O\nSaturday O\nor O\nearly O\non O\nSunday O\nfrom O\na O\nteak O\ntree O\nplantation O\nthey O\nmanage O\nby O\nat O\nleast O\ntwo O\nheavily O\narmed O\nmen O\nwho O\ntook O\nthe O\ntwo O\noff O\nin O\ntheir O\nown O\ncar O\n, O\nleaving O\nbehind O\na O\nransom O\nnote O\ndemanding O\n$ O\n1.5 O\nmillion O\n. O\n\nThe O\nplantation O\nis O\nowned O\nby O\nDutch B-MISC\ncitizen O\nEbe B-PER\nHuizinga I-PER\n, O\nwho O\nhas O\nsince O\narrived O\nin O\nCosta B-LOC\nRica I-LOC\nto O\ndeal O\nwith O\nthe O\nmatter O\n. O\n\n-DOCSTART- O\n\nGov't O\ndodging O\nextradition O\n, O\nColombian B-MISC\nofficial O\nsays O\n. O\n\nBOGOTA B-LOC\n, O\nColombia B-LOC\n1996-08-28 O\n\nA O\ntop O\njudicial O\nofficial O\nand O\ncritic O\nof O\nPresident O\nErnesto B-PER\nSamper I-PER\naccused O\nthe O\ngovernment O\nof O\nindifference O\non O\nWednesday O\nover O\nefforts O\nto O\nlift O\nColombia B-LOC\n's O\nfive-year-old O\nban O\non O\nextradition O\n. O\n\n\" O\nIt O\nwould O\nseem O\nthat O\nthe O\nsubject O\nof O\nextradition O\nis O\nunworthy O\nof O\nan O\nopinion O\nfrom O\nthe O\ngovernment O\n, O\n\" O\nDeputy O\nProsecutor-General O\nAdolfo B-PER\nSalamanca B-LOC\nsaid O\n. O\n\nConstitutional O\nreforms O\nwere O\nproposed O\non O\nTuesday O\nby O\ntwo O\nsenators O\n, O\none O\nof O\nthem O\na O\nmember O\nof O\nSamper B-PER\n's O\nown O\nLiberal B-ORG\nParty I-ORG\n, O\naimed O\nat O\nlifting O\nthe O\nban O\non O\nextradition O\nintroduced O\nin O\n1991 O\n. O\n\nU.S. B-LOC\nAmbassador O\nMyles B-PER\nFrechette I-PER\napplauded O\nthe O\nmove O\n, O\nsaying O\nit O\ncould O\nprompt O\nthe O\nClinton B-PER\nadministration O\nto O\nremove O\nColombia B-LOC\nfrom O\na O\nlist O\nof O\noutcast O\nnations O\nthat O\nhave O\nfailed O\nto O\ncooperate O\nin O\nU.S. B-LOC\ncounternarcotics O\nefforts O\n. O\n\nSamper B-PER\n-- O\nwho O\nweathered O\na O\nyear-old O\ncrisis O\nstemming O\nfrom O\ncharges O\nhe O\nfinanced O\nhis O\n1994 O\nelection O\ncampaign O\nwith O\ndrug O\nmoney O\n-- O\nappeared O\nless O\nthan O\nenthusiastic O\n, O\nhowever O\n. O\n\n\" O\nExtradition O\nis O\nnot O\non O\nthe O\ngovernment O\n's O\nlegislative O\nagenda O\n, O\n\" O\nhe O\ntold O\nreporters O\non O\nTuesday O\n. O\n\nHe O\nadded O\nthat O\nhe O\ndid O\nnot O\noppose O\nthe O\nidea O\nof O\nopening O\na O\npublic O\ndebate O\nover O\nthe O\nissue O\n. O\n\nBut O\nhe O\nfell O\nfar O\nshort O\nof O\nendorsing O\nthe O\nidea O\nof O\nputting O\nColombian B-MISC\ndrug O\nlords O\nonto O\nU.S.-bound O\nflights O\nto O\nserve O\nstiff O\npenalities O\nin O\nAmerican B-MISC\nprisons O\n. O\n\nSalamanca B-LOC\n, O\nwho O\nspoke O\nat O\na O\nmeeting O\non O\nkidnapping O\nin O\nColombia B-LOC\n, O\nhas O\nsaid O\nin O\nthe O\npast O\nthat O\nthere O\nwas O\nample O\nevidence O\nto O\nprove O\nthat O\nSamper B-PER\n's O\ncampaign O\nreceived O\nmillions O\nof O\ndollars O\nin O\ncontributions O\nfrom O\nthe O\ncountry O\n's O\ntop O\ndrug O\nlords O\n. O\n\n-DOCSTART- O\n\nQuake O\nshakes O\nCosta B-LOC\nRica I-LOC\nduring O\nHashimoto B-PER\nvisit O\n. O\n\nSAN B-LOC\nJOSE I-LOC\n, O\nCosta B-LOC\nRica I-LOC\n1996-08-28 O\n\nA O\nmoderate O\nearthquake O\nmeasuring O\n5.0 O\non O\nthe O\nRichter B-PER\nscale O\nshook O\nCosta B-LOC\nRica I-LOC\non O\nWednesday O\nduring O\na O\nvisit O\nby O\nJapanese B-MISC\nPrime O\nMinister O\nRyutaro B-PER\nHashimoto I-PER\n, O\nbut O\nthere O\nwere O\nno O\nreports O\nof O\ncasualties O\nor O\ndamage O\n, O\nofficials O\nsaid O\n. O\n\nThe O\nquake O\nstruck O\nat O\n11.16 O\na.m. O\n( O\n1716 O\nGMT B-MISC\n) O\nand O\nwas O\ncentred O\n10 O\nmiles O\n( O\n16 O\nkm O\n) O\nsouth O\nof O\nthe O\nport O\nof O\nQuepos B-LOC\n, O\nwhich O\nis O\n90 O\nmiles O\n( O\n140 O\nkm O\n) O\nsouth O\nof O\nthe O\ncapital O\nSan B-LOC\nJose I-LOC\n, O\nthe O\nCosta B-ORG\nRican I-ORG\nVolcanic I-ORG\nand I-ORG\nSeismologicial I-ORG\nObservatory I-ORG\nsaid O\n. O\n\nThe O\nquake O\nwas O\nfelt O\nfor O\nabout O\nseven O\nseconds O\nin O\nmost O\nof O\nthe O\ncountry O\nbut O\npreliminary O\nreports O\nsaid O\nno O\none O\nwas O\nhurt O\n, O\nit O\nadded O\n. O\n\nThe O\nquake O\ntook O\nplace O\na O\nfew O\nminutes O\nbefore O\nthe O\nend O\nof O\na O\nwelcoming O\nceremony O\nat O\nJuan B-LOC\nSantamaria I-LOC\nairport O\nfor O\nHashimoto B-PER\n, O\nwho O\nwas O\nstarting O\na O\nthree-hour O\nvisit O\nas O\npart O\nof O\na O\nLatin B-MISC\nAmerican I-MISC\ntour O\n. O\n\nHashimoto B-PER\n, O\nwho O\narrived O\nat O\n11 O\na.m. O\n( O\n1700 O\nGMT B-MISC\n) O\n, O\nshowed O\nno O\nsign O\nof O\nhaving O\nfelt O\nthe O\nquake O\n, O\nwitnesses O\nsaid O\n. O\n\n-DOCSTART- O\n\nBarrier O\nremoved O\nto O\nBrazil B-LOC\nCVRD B-ORG\nsell-off O\n. O\n\nBRASILIA B-LOC\n1996-08-28 O\n\nThe O\nBrazilian B-MISC\nSenate B-ORG\nWednesday O\nagreed O\nto O\nshelve O\na O\nbill O\nlinking O\nthe O\nprivatization O\nof O\nmining O\nconglomerate O\nVale B-ORG\ndo I-ORG\nRio I-ORG\nDoce I-ORG\nto O\ncongressional O\napproval O\n, O\nofficials O\nsaid O\n. O\n\nOfficials O\nsaid O\nthe O\nSenate B-ORG\nvote O\nremoved O\nall O\nexisting O\nlegislative O\nhurdles O\nin O\nthe O\nway O\nof O\nCVRD B-ORG\n's O\nsell-off O\n. O\n\nThe O\nmotion O\nwas O\nput O\nforward O\nby O\nSen B-LOC\n. O\n\nJose B-PER\nEduardo I-PER\nDutra I-PER\n, O\nwho O\nhad O\ndrawn O\nup O\nthe O\nbill O\n. O\n\nThe O\nSenate B-ORG\nvote O\nalso O\nannulled O\na O\nsubstitute O\nversion O\nof O\nDutra B-PER\n's O\nbill O\nwhich O\nhad O\nsought O\nto O\ndedicate O\nrevenue O\nfrom O\nVale B-ORG\n's O\nprivatization O\nto O\nregional O\ninfrastructure O\nprojects O\n. O\n\n-- O\nWilliam B-PER\nSchomberg I-PER\n, O\nBrasilia B-LOC\nnewsroom O\n55-61-2230358 O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nArthur B-ORG\nYates I-ORG\nyear O\nnet O\nA$ B-MISC\n6.1 O\nmln O\n. O\n\nSYDNEY B-LOC\n1996-08-29 O\n\nYear O\nto O\nJune O\n30 O\n\n( O\nmillion O\nA$ B-MISC\nunless O\nstated O\n) O\n\nOperating O\nprofit O\n9.75 O\nvs O\n5.79 O\n\nNet O\nprofit O\n6.08 O\nvs O\n3.98 O\n\nFinal O\ndividend O\n( O\ncents O\n) O\n4.0 O\nvs O\n4.0 O\n\nTotal O\ndividend O\n( O\ncents O\n) O\n6.0 O\nvs O\n6.0 O\n\nNOTE O\n: O\nArthur B-ORG\nYates I-ORG\nand I-ORG\nCo I-ORG\nltd O\nis O\na O\ngarden O\nproducts O\ngroup O\n. O\n\nSales O\n148.29 O\nvs O\n133.82 O\n\nOther O\nincome O\n1.90 O\nvs O\n2.07 O\n\nShr O\n( O\ncents O\n) O\n8.63 O\nvs O\n7.23 O\n\nDividend O\nis O\n100 O\npercent O\nfranked O\n\nPay O\ndate O\nNov O\n25 O\n\nReg O\ndate O\nNov O\n11 O\n\nTax O\n3.67 O\nvs O\n1.82 O\n\nInterest O\n2.78 O\nvs O\n2.69 O\n\nDepreciation O\n3.25 O\nvs O\n2.79 O\n\n-- O\nSydney B-LOC\nnewsroom O\n61-2 O\n9373-1800 O\n\n-DOCSTART- O\n\nBriton B-MISC\nheld O\nin O\nThailand B-LOC\nover O\n4.4 O\nkg O\nheroin O\nfind O\n. O\n\nBANGKOK B-LOC\n1996-08-28 O\n\nThai B-MISC\nairport O\npolice O\narrested O\na O\nBritish B-MISC\nbartender O\nfor O\nallegedly O\nattempting O\nto O\nboard O\na O\nflight O\nfor O\nAmsterdam B-LOC\nwith O\nnearly O\n4.4 O\nkg O\n( O\n9.68 O\nlb O\n) O\nof O\nheroin O\nin O\nhis O\nluggage O\n, O\npolice O\nsaid O\non O\nWednesday O\n. O\n\nPolice O\nsaid O\nJames B-PER\nLee I-PER\nWilliams I-PER\n, O\n28 O\n, O\nwas O\nstopped O\nat O\na O\nBangkok B-LOC\nairport O\ndeparture O\nlounge O\non O\nMonday O\nafter O\nofficials O\nfound O\nthe O\ndrug O\nin O\na O\nbag O\nthat O\nWilliams B-PER\nplanned O\nto O\ncarry O\nonto O\nthe O\nplane O\n. O\n\nWilliams B-PER\n' O\nhometown O\nwas O\nnot O\nimmediately O\navailable O\n. O\n\nThe O\nmaximum O\nsentence O\nfor O\nheroin O\ntrafficking O\nis O\nthe O\ndeath O\npenalty O\n, O\nalthough O\nit O\nis O\nnormally O\ncommuted O\nto O\nlife O\nimprisonment O\n. O\n\n-DOCSTART- O\n\nPLO B-ORG\nCouncil I-ORG\ncalls O\nfor O\nhalt O\nto O\ncontacts O\nwith O\nIsrael B-LOC\n. O\n\nRAMALLAH B-LOC\n, O\nWest B-LOC\nBank I-LOC\n1996-08-28 O\n\nThe O\nPalestinian B-ORG\nLegislative I-ORG\nCouncil I-ORG\non O\nWednesday O\ncalled O\nfor O\na O\nhalt O\nto O\ncontacts O\nwith O\nIsrael B-LOC\n, O\njust O\nhours O\nafter O\nPresident O\nYasser B-PER\nArafat I-PER\nsaid O\nthe O\nJewish B-MISC\nstate O\nhad O\neffectively O\ndeclared O\nwar O\non O\nthe O\nPalestinians B-MISC\nby O\npursuing O\nits O\nhardline O\npolicies O\n. O\n\nA O\nresolution O\nreleased O\nby O\nthe O\ncouncil O\ncalled O\nfor O\n\" O\nhalting O\ncontacts O\nwith O\nthe O\nIsraeli B-MISC\nside O\nand O\nleaving O\nthe O\nmechanism O\nto O\ncarry O\nout O\nthis O\nto O\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\n\" O\n. O\n\nThe O\ncouncil O\nwas O\nmeeting O\nin O\nRamallah B-LOC\nto O\ndiscuss O\nIsrael B-LOC\n's O\nnew O\npolicy O\nof O\nJewish B-MISC\nsettlement O\nexpansion O\nand O\nits O\nuncompromising O\nline O\non O\nJerusalem B-LOC\nsince O\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\ntook O\noffice O\nin O\nJune O\n. O\n\nCouncil O\nresolutions O\nare O\nnot O\nnecessarily O\nbinding O\n. O\n\nArafat B-PER\nhad O\nearlier O\nblasted O\nIsrael B-LOC\nsaying O\nits O\npolicies O\namounted O\nto O\na O\ndeclaration O\nof O\nwar O\nagainst O\nthe O\nPalestinian B-MISC\npeople O\n. O\n\nHe O\nalso O\ncalled O\nfor O\nthe O\nfirst O\ngeneral O\nstrike O\nin O\ntwo O\nyears O\nin O\nthe O\nWest B-LOC\nBank I-LOC\nand O\nGaza B-LOC\non O\nThursday O\n. O\n\n\" O\nWhat O\nhappened O\nconcerning O\ncontinuous O\nviolations O\nand O\ncrimes O\nfrom O\nthis O\nnew O\nIsraeli B-MISC\nleadership O\nmeans O\nthey O\nare O\ndeclaring O\na O\nstate O\nof O\nwar O\nagainst O\nthe O\nPalestinian B-MISC\npeople O\n, O\n\" O\nArafat B-PER\ntold O\nthe O\ncouncil O\n. O\n\nCouncil O\nspeaker O\nAhmed B-PER\nKorei I-PER\nsaid O\nthe O\ndecision O\nwas O\npart O\nof O\na O\ncomprehensive O\nplan O\nto O\nconfront O\nIsraeli B-MISC\nsettlement O\npolicy O\n, O\nland O\nconfiscation O\nand O\nwhat O\nhe O\ntermed O\nother O\nviolations O\nof O\nthe O\nIsraeli-PLO B-MISC\npeace O\ndeals O\n. O\n\n-DOCSTART- O\n\nIraqi B-MISC\nKurd I-MISC\ngroup O\nsays O\nagrees O\nnew O\nceasefire O\n. O\n\nANKARA B-LOC\n1996-08-28 O\n\nAn O\nIraqi B-MISC\nKurdish I-MISC\ngroup O\non O\nWednesday O\nsaid O\nit O\nhad O\nagreed O\na O\nnew O\nU.S.-brokered B-MISC\nceasefire O\nwith O\na O\nrival O\nfaction O\nafter O\na O\nprevious O\naccord O\nwas O\nshattered O\nby O\nsporadic O\nfighting O\nbetween O\nthe O\ngroups O\nin O\nrecent O\ndays O\n. O\n\n\" O\nThe O\nPatriotic B-ORG\nUnion I-ORG\nof I-ORG\nKurdistan I-ORG\n( O\nPUK B-ORG\n) O\nleadership O\ndeclares O\nits O\nendorsement O\nfor O\na O\nceasefire O\narrangement O\nwith O\nthe O\nKDP B-ORG\n( O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n) O\nto O\ntake O\neffect O\nas O\nof O\n8:00 O\na.m. O\non O\nAugust O\n28 O\n, O\n\" O\nthe O\nPUK B-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nPUK B-ORG\nsaid O\nthe O\nceasefire O\nwas O\nagreed O\nafter O\ntalks O\nbetween O\nU.S. B-LOC\nAssistant O\nSecretary O\nfor O\nNear B-LOC\nEast I-LOC\nAffairs O\nRobert B-PER\nPelletreau I-PER\nand O\nPUK B-ORG\nleader O\nJalal B-PER\nTalabani I-PER\n. O\n\nThe O\nKDP B-ORG\n, O\nled O\nby O\nMassoud B-PER\nBarzani I-PER\n, O\nhad O\nsaid O\na O\nprevious O\nceasefire O\nnegotiated O\nby O\nPelletreau B-PER\nlast O\nFriday O\nwas O\nbroken O\nby O\nthe O\nPUK B-ORG\n. O\n\nTalabani B-PER\nhas O\nagreed O\nto O\ntake O\npart O\nin O\ntalks O\nin O\nLondon B-LOC\non O\nreaching O\na O\ncomprehensive O\nsettlement O\nfor O\nthe O\nPUK-KDP B-MISC\nconflict O\n, O\nthe O\nPUK B-ORG\nstatement O\nsaid O\n. O\n\nIt O\nsaid O\nthe O\nKDP B-ORG\nwas O\nresponsible O\nfor O\nbreaking O\nthe O\nprevious O\nceasefire O\nby O\nrefusing O\nto O\nendorse O\nit O\npublicly O\n. O\n\n-DOCSTART- O\n\nKurd B-MISC\ngroup O\nsays O\nIraqi B-MISC\ntroops O\nmassing O\nnear O\nnorth O\n. O\n\nANKARA B-LOC\n1996-08-28 O\n\nAn O\nIraqi B-MISC\nKurdish I-MISC\ngroup O\non O\nWednesday O\nsaid O\nIraq B-LOC\nwas O\nmassing O\ntroops O\nnear O\nKurdish B-MISC\nregions O\nin O\nthe O\nnorth O\n, O\nwhere O\na O\nU.S.-led B-MISC\nallied O\nair O\nforce O\nprotects O\nthe O\nlocal O\npopulation O\nagainst O\nattacks O\nfrom O\nBaghdad B-LOC\n. O\n\n\" O\nThe O\nIraqi B-MISC\nregime O\nhas O\nstarted O\nthreatening O\nthe O\nKurdish B-MISC\npopulation O\nby O\nmassing O\ntroops O\nin O\npreparation O\nto O\nattack O\nKurdish B-MISC\ntowns O\nand O\npopulation O\ncentres O\n, O\n\" O\nthe O\nPatriotic B-ORG\nUnion I-ORG\nof I-ORG\nKurdistan I-ORG\n( O\nPUK B-ORG\n) O\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nPUK B-ORG\nsaid O\nit O\nhad O\nreceived O\nconfirmed O\nreports O\nthat O\nIraqi B-MISC\ntroops O\n, O\nsupported O\nby O\ntanks O\n, O\nartillery O\nand O\narmoured O\nvehicles O\n, O\nhave O\nalready O\npenetrated O\nsome O\nKurdish B-MISC\nareas O\n. O\n\nIt O\nsaid O\nthe O\nmilitary O\npresence O\nreflects O\ncooperation O\nbetween O\nPresident O\nSaddam B-PER\nHussein I-PER\nand O\nthe O\nPUK B-ORG\n's O\nrival O\n, O\nthe O\nKurdistan B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nKDP B-ORG\n) O\n. O\n\nThe O\nPUK B-ORG\nstatement O\nfollows O\nKDP B-ORG\nassertions O\nthat O\nthe O\nPUK B-ORG\nis O\nreceiving O\nmilitary O\nsupport O\nfrom O\nIran B-LOC\n. O\n\nHostilities O\nbetween O\nthe O\ntwo O\nwarring O\nIraqi B-MISC\nKurdish I-MISC\nfactions O\nhave O\ncontinued O\nin O\nthe O\nlast O\nfew O\ndays O\ndespite O\na O\nU.S.-brokered B-MISC\nceasefire O\nlast O\nFriday O\n. O\n\nThe O\nPUK B-ORG\ncalled O\non O\nthe O\nUnited B-ORG\nNations I-ORG\nand O\nallied O\nforces O\nto O\nhalt O\nthe O\nIraqi B-MISC\naggression O\n. O\n\nU.S. B-LOC\n, O\nFrench B-MISC\nand O\nBritish B-MISC\naircraft O\nhave O\nsafeguarded O\nthe O\nIraqi B-MISC\nKurdish I-MISC\npopulation O\nagainst O\naggression O\nfrom O\nBaghdad B-LOC\nsince O\nshortly O\nafter O\nthe O\nGulf B-MISC\nWar I-MISC\nin O\n1991 O\n. O\n\nThe O\nallied O\nforce O\n, O\nknown O\nas O\nOperation B-MISC\nProvide I-MISC\nComfort I-MISC\n, O\nis O\nbased O\nin O\nsouthern O\nTurkey B-LOC\n. O\n\n-DOCSTART- O\n\nIraq B-LOC\nsays O\nhijackers O\nwere O\nnot O\ndiplomats O\n. O\n\nBAGHDAD B-LOC\n1996-08-28 O\n\nIraq B-LOC\non O\nWednesday O\nsaid O\nthe O\nhijackers O\nof O\na O\nSudanese B-MISC\nairliner O\nwere O\nnot O\nIraqi B-MISC\ndiplomats O\nand O\nadded O\nthat O\n\" O\nnoble O\nIraqis B-MISC\n\" O\nwould O\nnever O\ncontemplate O\nsuch O\nan O\naction O\n. O\n\nThe O\nofficial O\nIraqi B-ORG\nNews I-ORG\nAgency I-ORG\n( O\nINA B-ORG\n) O\nquoted O\nIraq B-LOC\n's O\nambassador O\nin O\nKhartoum B-LOC\nas O\nsaying O\nthat O\nIraq B-LOC\n's O\nembassy O\nin O\nthe O\nSudanese B-MISC\ncapital O\nhad O\nnothing O\nto O\ndo O\nwith O\nthe O\nMonday O\nnight O\nhijacking O\n. O\n\nIraq B-LOC\n's O\nambassador O\nin O\nKhartoum B-LOC\ndenounced O\nthe O\nhijacking O\nand O\ndescribed O\nit O\nas O\na O\nterrorist O\nact O\nwhich O\nhad O\nnothing O\nto O\ndo O\n\" O\nwith O\nthe O\nmorals O\nand O\nvalues O\nof O\nnoble O\nIraqis B-MISC\n, O\n\" O\nINA B-ORG\nsaid O\n. O\n\nAmbassador O\nAbdulsamad B-PER\nHameed I-PER\nAli I-PER\ntold O\nINA B-ORG\nthere O\nwas O\nonly O\none O\ndiplomat O\namong O\nthe O\n199 O\npassengers O\nand O\ncrew O\non O\nthe O\nSudan B-ORG\nAirways I-ORG\nAirbus B-MISC\n. O\n\n\" O\nHe O\nwas O\nnot O\ninvolved O\n... O\n\non O\nthe O\ncontrary O\nhe O\nwas O\nharassed O\nby O\nthe O\nelements O\nwhich O\ncarried O\nout O\nthe O\nhijacking O\n, O\n\" O\nhe O\nsaid O\n. O\n\nINA B-ORG\ndid O\nnot O\nsay O\nthe O\nhijackers O\nwere O\nIraqis B-MISC\n. O\n\nThe O\nhijack O\nstarted O\nwhen O\nthe O\nflight O\nleft O\nKhartoum B-LOC\nfor O\nAmman B-LOC\non O\nMonday O\nnight O\n. O\n\nThe O\nhijackers O\ntold O\nthe O\ncrew O\nthey O\nhad O\ngrenades O\nand O\nother O\nexplosives O\nand O\nthreatened O\nto O\nblow O\nup O\nthe O\nplane O\nif O\nthey O\nwere O\nnot O\ntaken O\nto O\nLondon B-LOC\n. O\n\nThe O\nairliner O\nrefuelled O\nat O\nLarnaca B-LOC\n, O\nCyprus B-LOC\nand O\nlanded O\nat O\nLondon B-LOC\n's O\nStansted B-LOC\nairport O\nin O\nthe O\nearly O\nhours O\nof O\nTuesday O\n. O\n\nSeven O\nIraqi B-MISC\nsuspected O\nhijackers O\nsurrendered O\nand O\nBritish B-MISC\npolice O\nsaid O\nthey O\nhad O\napparently O\nasked O\nfor O\npolitical O\nasylum O\n. O\n\nSeveral O\nhad O\nbrought O\ntheir O\nfamilies O\nalong O\n, O\nincluding O\nchildren O\n. O\n\n-DOCSTART- O\n\nDole B-PER\nblasts O\nClinton B-PER\nfor O\nignoring O\nteen O\ndrug O\nuse O\n. O\n\nJudith B-PER\nCrosson I-PER\n\nVENTURA B-LOC\n, O\nCalif. B-LOC\n1996-08-28 O\n\nRepublican B-MISC\npresidential O\ncandidate O\nBob B-PER\nDole I-PER\nWednesday O\naccused O\nthe O\nClinton B-PER\nadministration O\nof O\nignoring O\ndrug O\nuse O\namong O\nteenagers O\nand O\nsaid O\nif O\nelected O\nhe O\nwould O\nuse O\nthe O\nNational B-ORG\nGuard I-ORG\nto O\nstop O\ndrugs O\nfrom O\nentering O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\n\" O\nHe O\n'll O\nprobably O\nmention O\nhis O\nwar O\non O\ndrugs O\n, O\nwhich O\nhe O\n's O\ngoing O\nto O\nstart O\nlike O\neverything O\nelse O\n-- O\nnext O\nyear O\n. O\n\nIt O\n's O\ntoo O\nlate O\n, O\nMr. O\nPresident O\n, O\n\" O\nDole B-PER\ntold O\nan O\noutdoor O\ncrowd O\nof O\nseveral O\nhundred O\nat O\na O\nprivate O\nreligious O\nschool O\n. O\n\nHe O\nalso O\ncommented O\nbriefly O\non O\npublished O\nreports O\nthat O\nthe O\nadministration O\nwas O\nplanning O\nto O\nannounce O\na O\nplan O\nto O\nlower O\ncapital O\ngains O\ntaxes O\nfor O\nhome O\nsales O\n. O\n\" O\n\nWelcome O\nto O\nthe O\nclub O\n. O\n\nWe O\n've O\nhad O\nit O\nout O\nthere O\nfor O\nweeks O\nand O\nweeks O\nand O\nweeks O\n, O\n\" O\nDole B-PER\nsaid O\n. O\n\nDole B-PER\nsaid O\nformer O\nfirst O\nlady O\nNancy B-PER\nReagan I-PER\nwas O\nlaughed O\nat O\nwith O\nher O\n\" O\njust O\nsay O\nno O\n\" O\nanti-drug O\nmessage O\n. O\n\" O\n\nBut O\nit O\nworked O\n, O\n\" O\nDole B-PER\nsaid O\n. O\n\nMeanwhile O\n, O\nin O\nLos B-LOC\nAngeles I-LOC\n, O\nDole B-PER\n's O\nrunning O\nmate O\n, O\nJack B-PER\nKemp I-PER\n, O\ncampaigned O\naggressively O\nfor O\nthe O\nblack O\nvote O\nin O\nan O\narea O\nthat O\nwas O\nthe O\nflashpoint O\nof O\nthe O\n1992 O\nLos B-LOC\nAngeles I-LOC\nriots O\n. O\n\nKemp B-PER\ntold O\na O\ncrowd O\nof O\nabout O\n300 O\nAfrican B-MISC\nAmericans I-MISC\nin O\nsouth O\ncentral O\nLos B-LOC\nAngeles I-LOC\n, O\n\" O\nKeep O\nyour O\neyes O\nopen O\n, O\nkeep O\nyour O\nears O\nopen O\n, O\nkeep O\nyour O\nheart O\nopen O\n. O\n\nI O\nwant O\nto O\ntell O\nyou O\nwith O\nall O\nmy O\nheart O\nthat O\nwe O\nwant O\nto O\nwin O\nyour O\nvote O\n. O\n\" O\n\nIn O\nDole B-PER\n's O\naddress O\nto O\na O\ngroup O\nthat O\nwas O\nlargely O\nwhite O\n, O\nthe O\npresidential O\nnominee O\nlikened O\nthe O\nstream O\nof O\nillegal O\ndrugs O\ninto O\nthe O\nUnited B-LOC\nStates I-LOC\nto O\nmissiles O\naimed O\nat O\nAmerican B-MISC\nchildren O\nand O\npromised O\nto O\nappoint O\nfederal O\njudges O\nwho O\nwould O\nbe O\ntough O\non O\nillegal O\ndrug O\nuse O\n. O\n\n\" O\nThey O\n're O\naiming O\nmillions O\nand O\nmillions O\nof O\nmissiles O\nright O\nat O\nthese O\nyoung O\npeople O\n, O\nwhether O\nit O\n's O\na O\nneedle O\n, O\nwhether O\nit O\n's O\na O\ncigarette O\n, O\nwhatever O\nthe O\ndelivery O\nsystem O\nis O\n-- O\nit O\n's O\npoison O\nand O\nit O\n's O\ngot O\nto O\nstop O\nin O\nAmerica B-LOC\n. O\n\" O\n\nhe O\nsaid O\n. O\n\nDole B-PER\nsaid O\n70 O\npercent O\nof O\nthe O\ncocaine O\nthat O\nentered O\nthe O\nUnited B-LOC\nStates I-LOC\nand O\n40 O\npercent O\nof O\nthe O\nmarijuana O\ncame O\nfrom O\nMexico B-LOC\n. O\n\" O\n\nWe O\n've O\ngot O\nan O\ninternational O\nproblem O\nand O\nI O\n'm O\nprepared O\nto O\nuse O\nour O\nmilitary O\nmight O\n. O\n\nWe O\nwant O\nto O\nstop O\ndrugs O\nat O\nthe O\nborder O\n, O\n\" O\nhe O\nsaid O\n. O\n\nDole B-PER\n's O\nremarks O\nprompted O\nquestions O\nabout O\nwhether O\nhe O\nwas O\nseeking O\na O\nban O\non O\ncigarettes O\n. O\n\" O\n\nI O\ndid O\nn't O\nsay O\nanything O\nabout O\ncigarettes O\n. O\n\nI O\nwas O\ntalking O\nabout O\ndrugs O\n. O\n\nI O\nsaid O\nyou O\nshould O\nn't O\nsmoke O\neither O\n. O\n\nThat O\n's O\nall O\nI O\nsaid O\n, O\n\" O\nhe O\nreplied O\nas O\nhe O\nwas O\nshaking O\nhands O\nwith O\nwell-wishers O\n. O\n\nWhen O\nasked O\nspecifically O\nif O\nhe O\nwas O\nsuggesting O\na O\nban O\non O\ncigarettes O\n, O\nDole B-PER\nreplied O\n: O\n\" O\nOh O\nno O\n. O\n\nCome O\non O\n, O\nyou O\nknow O\nbetter O\nthan O\nthat O\n. O\n\" O\n\nDole B-PER\ncampaign O\naides O\nsaid O\nthe O\ncandidate O\nwas O\ntelling O\nyoung O\npeople O\nnot O\nto O\nsmoke O\n. O\n\nDole B-PER\nalso O\nsaid O\nhe O\nopposed O\nCalifornia B-MISC\nProposition I-MISC\n215 I-MISC\nwhich O\n, O\nif O\napproved O\nby O\nvoters O\n, O\nwould O\nallow O\nthe O\ncultivation O\nof O\nmarijuana O\nplants O\nfor O\nmedicinal O\nuses O\n. O\n\nDole B-PER\nsaid O\nthe O\ninitiative O\nwould O\nallow O\nmarijuana O\nto O\nbe O\nused O\nfor O\nanything O\nfrom O\na O\nheadache O\nto O\nan O\ningrown O\ntoenail O\n. O\n\nIn O\nan O\neffort O\nto O\npaint O\nthe O\ndrug O\nissue O\nin O\nnon-political O\nterms O\n, O\nDole B-PER\nsaid O\nthree O\ntimes O\nduring O\nhis O\n20-minute O\naddress O\nthat O\nillegal O\ndrug O\nuse O\nwas O\nneither O\na O\nDemocratic B-MISC\nnor O\na O\nRepublican B-MISC\nissue O\nbut O\none O\nthat O\ninvolves O\nall O\npeople O\n. O\n\nThe O\nanti-drug O\nmessage O\nis O\na O\ntheme O\nDole B-PER\nfeels O\nhas O\nstrong O\nvoter O\nappeal O\n. O\n\nOn O\nSunday O\nnear O\nChicago B-LOC\nhe O\naccused O\nPresident O\nBill B-PER\nClinton I-PER\nof O\n\" O\nraising O\nthe O\nwhite O\nflag O\n\" O\nin O\nthe O\nwar O\non O\ndrugs O\n. O\n\nA O\nrecent O\nsurvey O\nshowed O\nthat O\nillegal O\ndrug O\nuse O\namong O\n12-17 O\nyear-olds O\nhad O\ndoubled O\nin O\nthe O\npast O\nfour O\nyears O\n. O\n\nDole B-PER\nwas O\nflanked O\nby O\nseveral O\nCalifornia B-LOC\nRepublican B-MISC\npoliticians O\nincluding O\nGov O\n. O\n\nPete B-PER\nWilson I-PER\n, O\nwho O\nsaid O\nlocal O\nand O\nstate O\ngovernments O\ncannot O\nfight O\nillegal O\ndrugs O\nalone O\n. O\n\n\" O\nWe O\nneed O\nall O\nthe O\nhelp O\nwe O\ncan O\nget O\n. O\n\nWe O\nneed O\nto O\nget O\nthe O\nkind O\nof O\nhelp O\nwe O\nused O\nto O\nget O\nwhen O\nRonald B-PER\nReagan I-PER\nand O\nGeorge B-PER\nBush I-PER\nwere O\nin O\nthe O\nWhite B-LOC\nHouse I-LOC\n, O\n\" O\nWilson B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nBALANCE-Water B-MISC\nDist I-MISC\n1 I-MISC\nJohnson B-LOC\nCty I-LOC\n, O\nKan B-LOC\n. O\n\n, O\nat O\n$ O\n11 O\nmln O\n. O\n\nWATER B-MISC\nDISTRICT I-MISC\n1 I-MISC\nOF O\nJOHNSON B-ORG\nCO I-ORG\n. O\n\n, O\nKS B-LOC\n\nRE O\n: O\n$ O\n45,020,000 O\n\nWATER O\nREVENUE O\nBONDS O\n\n$ O\n22,040,000 O\nSER O\n. O\n\n1996A O\n\n$ O\n22,980,000 O\nRFDG O\n, O\nSER O\n. O\n\n1996B O\n\nMOODY B-ORG\n'S I-ORG\n: O\nAa O\nS&P B-ORG\n: O\nAA+ O\n\nDelivery O\nDate O\n: O\n09/05/1996 O\n( O\nFIRM O\n) O\n\n06/01 O\n12/01 O\n\nMATURITY O\nSER O\nA O\nSER O\nB O\nSER O\nA O\nSER O\nB O\n\n------------------------------------------------------------- O\n\n1998 O\n665M O\n840M O\n570M O\n\n2000 O\n- O\n- O\n605M O\n\n2001 O\n- O\n70M O\n- O\n\n2002 O\n- O\n895M O\n600M O\n\n2003 O\n705M O\n- O\n795M O\n\n2004 O\n655M O\n90M O\n965M O\n\n2009 O\n65M O\n- O\n- O\n\n2010 O\n60M O\n- O\n100M O\n\n2011 O\n30M O\n- O\n90M O\n\n2012 O\n20M O\n- O\n35M O\n\nTOTAL O\n: O\n11,450 O\n\nA.G. B-ORG\nEdwards I-ORG\n& I-ORG\nSons I-ORG\n, I-ORG\nInc I-ORG\n. O\n\n-- O\nU.S. B-ORG\nMunicipal I-ORG\nDesk I-ORG\n, O\n212-859-1650 O\n\n-DOCSTART- O\n\nCME B-ORG\nlumber O\nfutures O\nclose O\nlower O\non O\nprofit O\ntaking O\n. O\n\nCHICAGO B-LOC\n1996-08-28 O\n\nProfit O\ntaking O\ncontinued O\nto O\nweigh O\non O\nCME B-ORG\nlumber O\nfutures O\nbut O\nprices O\nended O\nonly O\nslightly O\nlower O\nas O\nstrong O\ncash O\nmarkets O\nunderpinned O\nfutures O\n, O\ntraders O\nsaid O\n. O\n\nThe O\nsame O\npattern O\nof O\nthe O\npast O\nfew O\ndays O\npersisted O\nwith O\nfutures O\ndeclining O\nearly O\non O\nthe O\nprofit O\ntaking O\nbefore O\nfirming O\nlate O\n. O\n\nThere O\nwas O\ncash-related O\nbuying O\nlate O\nfrom O\npeople O\nwho O\nwant O\nto O\ntake O\ndelivery O\nof O\nthe O\nSeptember O\ncontract O\n, O\nthey O\nsaid O\n. O\n\nCash O\nsources O\nnoted O\nthat O\nalthough O\nthe O\ncash O\nmarket O\nis O\ngenerally O\nquiet O\n, O\nprices O\nremain O\nfirm O\non O\ndemand O\nfor O\nprompt O\ndelivery O\nwood O\n, O\nthey O\nadded O\n. O\n\nRandom O\nLengths O\nquoted O\ncash O\nspruce O\nat O\n$ O\n419 O\nper O\ntbf O\n, O\nup O\n$ O\n5 O\nfrom O\nlast O\nFriday O\nand O\n$ O\n7 O\nover O\nthe O\nlast O\nmidweek O\nquote O\n. O\n\nReduced O\nconcern O\nover O\nHurricane O\nEdouard B-MISC\nprompted O\nsome O\nof O\nthe O\nearly O\nprofit O\ntaking O\n. O\n\nExpectations O\nthe O\nstorm O\nwould O\nturn O\nmore O\nto O\nthe O\nnorth O\npartly O\neased O\nconcerns O\n, O\nthey O\nsaid O\n. O\n\nLumber O\nclosed O\n$ O\n2.20 O\nto O\n$ O\n0.20 O\nper O\ntbf O\nlower O\nwith O\nSeptember O\noff O\n$ O\n0.70 O\nat O\n$ O\n413.20 O\nand O\nNovember O\noff O\nmost O\nat O\n$ O\n369.00 O\nper O\ntbf O\n. O\n\n-- O\nJerry B-PER\nBieszk I-PER\n312-408-8725 O\n\n-DOCSTART- O\n\nWHEAT--Rains O\nboost O\nU.S. B-LOC\nHRW O\nplanting O\nprospects O\n. O\n\nGreg B-PER\nFrost I-PER\n\nKANSAS B-LOC\nCITY I-LOC\n, O\nMo B-LOC\n. O\n\n1996-08-28 O\n\nAbove-normal O\nsummer O\nrainfall O\nin O\nthe O\nU.S. B-LOC\nHigh B-LOC\nPlains I-LOC\nhas O\nproduced O\nnear-ideal O\nconditions O\nfor O\nplanting O\nthe O\n1997 O\nhard O\nred O\nwinter O\nwheat O\ncrop O\n, O\nanalysts O\nsaid O\nWednesday O\n. O\n\nFrom O\ncentral O\nTexas B-LOC\nnorth O\nto O\nKansas B-LOC\n, O\nrains O\nthroughout O\nJuly O\nand O\nAugust O\nhave O\nrelieved O\nmost O\nof O\nthe O\ndrought O\nconditions O\nthat O\nplagued O\nthe O\nregion O\nearlier O\nthis O\nyear O\n. O\n\n\" O\nOur O\nmoisture O\nsituation O\nis O\nexcellent O\n, O\nespecially O\nfor O\nfall O\nplanting O\nof O\nwinter O\nwheat O\n, O\n\" O\nsaid O\nKim B-PER\nAnderson I-PER\n, O\nextension O\nwheat O\nmarketing O\neconomist O\nat O\nOklahoma B-ORG\nState I-ORG\nUniversity I-ORG\n. O\n\nThe O\nirony O\nof O\nthe O\nabove-average O\nsummer O\nrainfall O\nwas O\nnot O\nlost O\non O\nHigh B-LOC\nPlains I-LOC\nwheat O\nproducers O\n, O\nwho O\nonly O\nthree O\nmonths O\nago O\nwere O\ncaught O\nin O\na O\ndrought O\nso O\nsevere O\nthat O\nold-timers O\nlikened O\nconditions O\nto O\nthe O\n\" O\nDust B-MISC\nBowl I-MISC\n\" O\ndays O\nof O\nthe O\n1930s O\n. O\n\n\" O\nIt O\n's O\ndefinitely O\na O\nturnabout O\nfrom O\nthis O\npast O\nyear O\n, O\nbut O\nyou O\nknow O\nlast O\nyear O\nwe O\nhad O\npretty O\ngood O\nmoisture O\nabout O\nthis O\ntime O\nof O\nyear O\n, O\nand O\nthen O\nabout O\nOctober O\n1 O\nit O\nquit O\n, O\n\" O\nsaid O\nMark B-PER\nHodges I-PER\n, O\nexecutive O\ndirector O\nof O\nthe O\nOklahoma B-ORG\nWheat I-ORG\nCommission I-ORG\n. O\n\" O\n\nHopefully O\nthat O\n's O\nnot O\ngoing O\nto O\nhappen O\nthis O\nyear O\n. O\n\" O\n\nAccording O\nto O\nfigures O\nreleased O\nby O\nthe O\nOklahoma B-MISC\nClimatological I-MISC\nSurvey I-MISC\n, O\nan O\naverage O\nof O\n20.19 O\ninches O\nfell O\nacross O\nthe O\nstate O\nbetween O\nMarch O\n1 O\nand O\nAugust O\n26 O\n, O\n1996 O\n. O\n\nThat O\n's O\nabout O\n1/2 O\ninch O\nabove O\nthe O\naverage O\nfor O\nthe O\nsame O\ntime O\nperiod O\n, O\naccording O\nto O\nHoward B-PER\nJohnson I-PER\n, O\nassociate O\nstate O\nclimatologist O\nat O\nthe O\nUniversity B-ORG\nof I-ORG\nOklahoma I-ORG\n. O\n\nHe O\nnoted O\nthat O\nthe O\nmajority O\nof O\nthat O\n20.19 O\ninches O\nhad O\nfallen O\nsince O\nJuly O\n. O\n\nAs O\nan O\nexample O\nof O\njust O\nhow O\ndry O\nit O\nwas O\n, O\ndata O\nshowed O\nthat O\nbetween O\nOctober O\n1 O\n, O\n1995 O\nand O\nMarch O\n1 O\n, O\n1996 O\n, O\nthe O\nstate O\nreceived O\nan O\naverage O\nof O\nonly O\n4.6 O\ninches O\nof O\nrainfall O\n. O\n\nIn O\nnorthern O\nTexas B-LOC\n, O\nthe O\ncurrent O\nrainfall O\nsituation O\nwas O\nsimilar O\nto O\nmost O\nof O\nOklahoma B-LOC\n, O\nsaid O\nRodney B-PER\nMosier I-PER\n, O\nexecutive O\nassistant O\nfor O\nthe O\nTexas B-ORG\nWheat I-ORG\nProducers I-ORG\n. O\n\n\" O\nUp O\nhere O\nin O\nthe O\nTexas B-LOC\nPanhandle I-LOC\n, O\nwe O\n've O\nhad O\nsome O\nextremely O\nbeneficial O\nrains O\nthat O\ncame O\nthrough O\nwithin O\nthe O\nlast O\nseveral O\ndays O\nand O\nare O\nreally O\nsetting O\nus O\nup O\nfor O\nideal O\nconditions O\nfor O\nplanting O\nwheat O\n, O\n\" O\nMosier B-PER\nsaid O\n. O\n\nBut O\nhe O\nwarned O\nthat O\nthe O\nsituation O\nwas O\nnot O\nas O\nideal O\nin O\ncentral O\nand O\nsouthern O\nTexas B-LOC\n, O\nwhere O\nmositure O\nlevels O\nwere O\nstill O\nshort O\ndespite O\nthe O\nrains O\nbrought O\nby O\nHurricane O\nDolly B-MISC\nlast O\nweek O\n. O\n\nIn O\nKansas B-LOC\n, O\ntypically O\nthe O\nnumber O\none O\nU.S. B-LOC\nhard O\nred O\nwinter O\nwheat O\nproducer O\n, O\ntopsoil O\nmoisture O\nlevels O\nwere O\nrated O\nmostly O\nadequate O\nduring O\nthe O\nweek O\nended O\nSunday O\n, O\naccording O\nto O\nthe O\nstate O\n's O\nagricultural O\nstatistics O\nservice O\n. O\n\nIn O\nits O\nweekly O\nreport O\nreleased O\nMonday O\n, O\nthe O\nservice O\nsaid O\nKansas B-LOC\ntopsoil O\nmoisture O\nwas O\nrated O\neight O\npercent O\nsurplus O\n, O\n77 O\npercent O\nadequate O\nand O\n15 O\npercent O\nshort O\nto O\nvery O\nshort O\n. O\n\nOklahoma B-LOC\n's O\nAgricultural B-ORG\nStatistics I-ORG\nService I-ORG\nshowed O\nsimilar O\nconditions O\n, O\nrating O\ntopsoil O\nmoisture O\nlevels O\nas O\nseven O\npercent O\nsurplus O\n, O\n81 O\npercent O\nadequate O\nand O\n12 O\npercent O\nshort O\nto O\nvery O\nshort O\n. O\n\nData O\non O\ntopsoil O\nmoisture O\nratings O\nwere O\nnot O\nreleased O\nby O\nthe O\nTexas B-ORG\nAgricultural I-ORG\nStatistics I-ORG\nService I-ORG\n. O\n\n-- O\nGreg B-PER\nFrost I-PER\n, O\n816 O\n561-8671 O\n\n-DOCSTART- O\n\nFirst B-ORG\nUnion I-ORG\nNational I-ORG\nBank I-ORG\nof I-ORG\nFla. I-ORG\nsettles O\nsuit O\n. O\n\nJACKSONVILLE B-LOC\n, O\nFla. B-LOC\n1996-08-28 O\n\nFirst B-ORG\nUnion I-ORG\nNational I-ORG\nBank I-ORG\nof I-ORG\nFlorida I-ORG\nsaid O\non O\nWednesday O\nit O\nagreed O\nto O\nsettle O\na O\nclass O\naction O\nlaw O\nsuit O\ninvolving O\nits O\ncollateral O\nprotection O\ninsurance O\n( O\nCPI B-MISC\n) O\nprogram O\n. O\n\nTo O\nprovide O\nfor O\nthe O\nsettlements O\n, O\nFirst B-ORG\nUnion I-ORG\nhas O\nestablished O\na O\ncommon O\nfund O\nof O\n$ O\n4.7 O\nmillion O\nfor O\ncash O\nrefunds O\nand O\n$ O\n19.4 O\nmillion O\nin O\ncredit O\nrefunds O\nfor O\noutstanding O\nCPI B-MISC\nbalances O\n. O\n\nThe O\nbank O\nis O\na O\ndivision O\nof O\nFirst B-ORG\nUnion I-ORG\nCorp I-ORG\n. O\n\nThe O\nbank O\nsaid O\nmost O\nof O\nthe O\ncharges O\nresulted O\nfrom O\nloan O\nportfolios O\nfrom O\nbanks O\nand O\nthrifts O\nthat O\nwere O\nacquired O\nin O\nthe O\n1980s O\n. O\n\nFirst B-ORG\nUnion I-ORG\nsaid O\nit O\nhas O\ndiscontinued O\nCPI B-MISC\nas O\nan O\nelement O\nof O\nits O\nmotor O\nvehicle O\nor O\nboat O\ninstallment O\nloan O\ncontracts O\n. O\n\nAs O\npart O\nof O\nthe O\nsettlement O\nagreement O\n, O\ncustomers O\nwho O\nhad O\nCPI B-MISC\nplaced O\non O\nloans O\nfrom O\nJanuary O\n1 O\n, O\n1986 O\nto O\nSeptember O\n31 O\n, O\n1996 O\n, O\nwill O\nreceive O\ncash O\nor O\ncredit O\nrefunds O\n, O\nthe O\nbank O\nsaid O\n. O\n\nCash O\nrefunds O\nwill O\ngo O\nto O\nthose O\nwho O\npaid O\ntheir O\nloans O\nto O\nFirst B-ORG\nUnion I-ORG\nwhile O\ncredit O\nrefunds O\nwill O\ngo O\nto O\nthose O\nwho O\nhave O\nexisting O\nloan O\nbalances O\n, O\nthe O\nbank O\nsaid O\n. O\n\n-DOCSTART- O\n\nAmoco B-ORG\nsays O\nin O\ntalks O\nover O\nYemen B-LOC\noil O\nacreage O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nAmoco B-ORG\nCorp I-ORG\nofficials O\nsaid O\nthe O\ncompany O\nis O\nin O\ntalks O\nover O\ncrude O\noil O\nproduction O\nsharing O\nin O\nYemen B-LOC\n, O\nbut O\ndeclined O\nto O\ncomment O\non O\na O\npublished O\nreport O\nAmoco B-ORG\nhad O\nreached O\npreliminary O\nagreement O\non O\na O\nblock O\nin O\nthe O\nShabwa B-LOC\narea O\n. O\n\n\" O\nWe O\n've O\nbeen O\nasked O\n( O\nby O\nYemen B-LOC\n) O\nnot O\nto O\ncomment O\n( O\non O\nthe O\ntalks O\n) O\n, O\n\" O\nsaid O\nAmoco B-ORG\nspokesman O\nDan B-PER\nDietsch I-PER\n. O\n\" O\n\nWe O\ncan O\nneither O\nconfirm O\nnor O\ndeny O\nthat O\nreport O\n, O\n\" O\nhe O\nsaid O\n. O\n\nAccording O\nto O\nMiddle B-MISC\nEast I-MISC\nEconomic I-MISC\nSurvey I-MISC\n( O\nMEES B-MISC\n) O\n, O\nYemen B-LOC\nand O\nAmoco B-ORG\nsigned O\na O\n\" O\nmemorandum O\nof O\nunderstanding O\n\" O\nfor O\na O\nproduction-sharing O\nagreement O\nin O\nShabwa B-MISC\nBlock I-MISC\nNo I-MISC\n. I-MISC\n\nS-1 B-MISC\nin O\nthe O\nformer O\nSouth B-LOC\nYemen I-LOC\n, O\nwhich O\nunited O\nwith O\nNorth B-LOC\nYemen I-LOC\nin O\n1990 O\n. O\n\nAccording O\nto O\nanother O\nAmoco B-ORG\nofficial O\n, O\nthe O\ncompany O\nis O\nnot O\nexploring O\nnow O\nfor O\noil O\nanywhere O\nin O\nYemen B-LOC\n. O\n\nThe O\nofficials O\nsaid O\nAmoco B-ORG\nwas O\ndeferring O\nto O\nthe O\nYemeni B-MISC\nMinistry B-ORG\nof I-ORG\nPetroleum I-ORG\nand I-ORG\nMinerals I-ORG\nfor O\nany O\nspecific O\ncomments O\non O\nthe O\nAmoco-Yemen B-MISC\ntalks O\n. O\n\nThe O\nformer O\nSoviet B-LOC\nUnion I-LOC\nwas O\ndisplaced O\nas O\ncontractor O\nof O\nthe O\npotentially O\nrich O\nShabwa B-LOC\noilfields O\nonce O\nit O\ncollapsed O\nin O\nDecember O\n1991 O\n, O\naccording O\nto O\nthe O\nInternational B-MISC\nPetroleum I-MISC\nEncyclopedia I-MISC\n. O\n\n-- O\nOliver B-PER\nLudwig I-PER\n, O\nNew B-ORG\nYork I-ORG\nEnergy I-ORG\nDesk I-ORG\n+1 O\n212 O\n859 O\n1633 O\n\n-DOCSTART- O\n\nBurundi B-LOC\ndefends O\nmilitary O\nregime O\nto O\nhostile O\nUN B-ORG\n. O\n\nEvelyn B-PER\nLeopold I-PER\n\nUNITED B-ORG\nNATIONS I-ORG\n1996-08-28 O\n\nBurundi B-LOC\n's O\nambassador O\non O\nWednesday O\nlashed O\nout O\nat O\neconomic O\nsanctions O\nimposed O\nby O\nAfrican B-MISC\nstates O\nand O\nsaid O\nany O\nthought O\nof O\nan O\narms O\nembargo O\nwould O\nbe O\na O\nwindfall O\nfor O\nguerrillas O\nfighting O\nhis O\narmy-run O\ngovernment O\n. O\n\nIn O\na O\nlengthy O\ndebate O\non O\nBurundi B-LOC\nbefore O\nthe O\nU.N. B-ORG\nSecurity I-ORG\nCouncil I-ORG\n, O\nAmbassador O\nNsanze B-PER\nTerence I-PER\nsaid O\nthe O\nnew O\nmilitary O\ngovernment O\ntook O\nover O\nto O\nstabilise O\nthe O\ncountry O\nand O\nwanted O\nnegotiations O\nunder O\nformer O\nTanzanian B-MISC\nPresident O\nJulius B-PER\nNyrere I-PER\n. O\n\nNearly O\nevery O\nAfrican B-MISC\nmember O\nwho O\nspoke O\n, O\nas O\nwell O\nas O\nmost O\nSecurity B-ORG\nCouncil I-ORG\nmembers O\n, O\nhowever O\n, O\nwere O\nunsympathetic O\ntowards O\nthe O\ngovernment O\nof O\nPresident O\nPierre B-PER\nBuyoya I-PER\n, O\nan O\narmy O\nmajor O\nput O\nin O\npower O\nin O\na O\nJuly O\ncoup O\nby O\nthe O\nTutsi-run B-MISC\nmilitary O\n, O\nwhich O\nis O\nlocked O\nin O\na O\nguerrilla O\nwar O\nwith O\nthe O\nmajority O\nHutus B-MISC\n. O\n\n\" O\nThese O\n( O\nAfrican B-MISC\n) O\nbrothers O\nshould O\nhave O\nbeen O\nthe O\nfirst O\nto O\nbind O\nthe O\nwounds O\nof O\nBurundi B-LOC\n, O\n\" O\nTerence B-PER\nsaid O\nof O\nthe O\neconomic O\nembargo O\n. O\n\" O\n\nQuite O\nthe O\ncontrary O\n, O\nBurundi B-LOC\nhas O\nseen O\neconomic O\nwar O\ndeclared O\nagainst O\nit O\nby O\nfellow O\nAfrican B-MISC\npeople O\n... O\na O\ngratuitous O\nimmolation O\nof O\nthe O\npeople O\nof O\nBurundi B-LOC\n. O\n\" O\n\nHe O\nsaid O\nhis O\ngovernment O\nhad O\njust O\nasked O\nU.N. B-ORG\nhuman O\nrights O\nmonitors O\nto O\nincrease O\ntheir O\nnumbers O\nin O\nBurundi B-LOC\nin O\nan O\neffort O\n\" O\nto O\nput O\nan O\nend O\nto O\nthis O\nvicious O\ncircle O\nof O\nviolence O\n. O\n\" O\n\nMore O\nthan O\n150,000 O\npeople O\nhave O\nbeen O\nkilled O\nin O\nviolence O\nbetween O\nthe O\nminority O\nTutsis B-MISC\nand O\nthe O\nmajority O\nHutus B-MISC\nsince O\n1993 O\n. O\n\nBotswana B-LOC\n's O\nenvoy O\n, O\nMothusi B-PER\nNkgowe I-PER\n, O\nsaid O\ncoups O\nshould O\nbe O\nrelegated O\n\" O\nto O\nthe O\ndump O\nheap O\nof O\nhistory O\n\" O\nas O\nthere O\ncould O\nbe O\nno O\njustification O\nfor O\nthe O\noverthrow O\nof O\na O\nlegitimate O\ngovernment O\n. O\n\nChile B-LOC\nhas O\nproposed O\na O\nresolution O\n, O\nstill O\nunder O\ndiscussion O\n, O\nthat O\nwould O\nimpose O\nan O\nimmediate O\narms O\nembargo O\non O\nBurundi B-LOC\nand O\ncall O\nfor O\nnegotiations O\n. O\n\nThe O\ndraft O\nsuggests O\nfurther O\nsanctions O\nagainst O\nthose O\nwho O\nimpede O\na O\npolitical O\nsolution O\n. O\n\nAmong O\nthe O\ncouncil O\n's O\nfive O\npermanent O\nmembers O\n, O\nRussia B-LOC\nand O\nthe O\nUnited B-LOC\nStates I-LOC\nappeared O\nto O\nsupport O\nmost O\nelements O\nof O\nthe O\nChilean B-MISC\nproposal O\n, O\nwhile O\nBritain B-LOC\n, O\nFrance B-LOC\nand O\nChina B-LOC\nwere O\ncautious O\n. O\n\nTerence B-PER\n, O\na O\nTutsi B-MISC\n, O\nsaid O\nany O\narms O\nembargo O\nwould O\nleave O\nthe O\narmy O\nunable O\nto O\ndefend O\nitself O\nagainst O\nHutu B-MISC\nguerrillas O\nand O\nleave O\nthe O\npopulation O\nexposed O\nto O\n\" O\narmed O\nterroritsts O\n. O\n\" O\n\nBut O\nChilean B-MISC\nAmbassador O\nJuan B-PER\nSomavia I-PER\nsaid O\n: O\n\" O\nEvery O\nweapon O\nthat O\nreached O\nBurundi B-LOC\nis O\na O\nweapon O\naimed O\nmainly O\nat O\nkilling O\nan O\nunarmed O\ncivilian O\n. O\n\nWe O\nmust O\nnot O\nsend O\na O\nsignal O\ndifferent O\nfrom O\nthe O\nAfrican B-MISC\nleaders O\nthemselves O\n. O\n\nInaction O\nis O\nbecoming O\nthe O\nworst O\npossible O\ncourse O\nof O\naction O\n. O\n\" O\n\nBurundi B-LOC\n's O\nparliament O\nhas O\nbeen O\nsuspended O\nand O\npolitical O\nparties O\nare O\nbanned O\nbut O\nTerence B-PER\ntold O\nreporters O\nBuyoya B-PER\nwould O\nreconvene O\na O\nnew O\ntype O\nof O\nnational O\nassembly O\nin O\nOctober O\n. O\n\nThe O\nUnited B-LOC\nStates I-LOC\nsaid O\nthe O\ncoup O\nleaders O\nhad O\ntaken O\nno O\nsteps O\nto O\nrestore O\ndemocracy O\nand O\nindiscriminate O\nkillings O\ncontinued O\n. O\n\nAmbassador O\nKarl B-PER\nInderfurth I-PER\nsaid O\nthe O\nnew O\ngovernment O\nshould O\nhave O\n\" O\nunconditional O\n\" O\nnegotiations O\nwith O\nall O\nparties O\ninside O\nand O\noutside O\nof O\nthe O\ncountry O\n. O\n\nHe O\nsaid O\nWashington B-LOC\nstrongly O\nsupported O\nthe O\neconomic O\nsanctions O\nimposed O\nalready O\nand O\nif O\nthese O\ndid O\nnot O\nwork O\nthe O\ncouncil O\nwould O\nconsider O\n\" O\nan O\narms O\nembargo O\nor O\ntargeted O\nsanctions O\nagainst O\nfaction O\nleaders O\n. O\n\" O\n\nBut O\nhe O\nsaid O\nthe O\ninternational O\ncommunity O\nhad O\nto O\nbe O\nprepared O\nfor O\nthe O\nworst O\nand O\navoid O\na O\nreplay O\nof O\nthe O\nhorrors O\nin O\nneighbouring O\nRwanda B-LOC\n, O\nwhere O\nwidespread O\ngenocide O\nbroke O\nout O\nagainst O\nthe O\nTutsis B-MISC\ntwo O\nyears O\nago O\n. O\n\nHe O\nagain O\nsaid O\nthe O\nUnited B-ORG\nNations I-ORG\nshould O\ndraw O\nup O\ncontingency O\nplans O\nfor O\na O\nrapid O\nhumanitarian O\nintervention O\n. O\n\n-DOCSTART- O\n\nSwiss B-MISC\narrest O\nRwandan B-MISC\non O\ngenocide O\nsuspicion O\n. O\n\nBERNE B-LOC\n1996-08-28 O\n\nSwiss B-MISC\nauthorities O\nsaid O\non O\nWednesday O\nthey O\nhad O\narrested O\na O\nformer O\nRwandan B-MISC\nmayor O\n, O\nnow O\nliving O\nin O\nSwitzerland B-LOC\n, O\non O\nsuspicion O\nof O\nviolating O\nhuman O\nrights O\nduring O\nthe O\ngenocide O\nin O\nhis O\ncountry O\nin O\n1994 O\n. O\n\nThe O\nDefence B-ORG\nMinistry I-ORG\nsaid O\nin O\na O\nstatement O\nthat O\ninvestigations O\nwere O\nstill O\nin O\nthe O\npreliminary O\nstage O\nbut O\nit O\nwas O\ncooperating O\nclosely O\nwith O\npolice O\nin O\nthe O\ncantons O\nof O\nGeneva B-LOC\nand O\nFreiburg B-LOC\n. O\n\nIt O\ndid O\nnot O\nidentify O\nthe O\nman O\n. O\n\n-DOCSTART- O\n\nOPTIONS O\n-- O\nEOE B-ORG\noptions O\nvolumes O\n- O\nclose O\n. O\n\nAMSTERDAM B-LOC\n1996-08-28 O\n\n1605 O\nGMT B-MISC\n\nCALLS O\nPUTS O\nPCT O\nOF O\nTOTAL O\n\nTOTAL O\nVOLUME O\n-- O\n83,008 O\n60,131 O\n22,877 O\n-- O\n\nFEATURES O\n- O\nAEX B-MISC\nINDEX O\n7,391 O\n5,658 O\n15.72 O\n\n- O\nAHOLD B-ORG\n7,190 O\n1,123 O\n10.01 O\n\n- O\nBOLSWESSANEN B-ORG\n4,420 O\n705 O\n6.17 O\n\n- O\nABN B-ORG\nAMRO I-ORG\n3,003 O\n1,940 O\n5.95 O\n\n- O\nING B-ORG\n3,853 O\n673 O\n5.45 O\n\n- O\nVNU B-ORG\n3,060 O\n843 O\n4.70 O\n\n-- O\nAmsterdam B-LOC\nnewsdesk O\n+31 O\n20 O\n504 O\n5000 O\n( O\nFax O\n020-504-5040 O\n) O\n\n-DOCSTART- O\n\nFrench B-MISC\ntax O\noffice O\nsucks O\nin O\nmoney O\n. O\n\nPARIS B-LOC\n1996-08-28 O\n\nWorkers O\nfixing O\nthe O\nceiling O\nof O\na O\ntax O\noffice O\nin O\nParis B-LOC\nfound O\na O\ndozen O\nseven-year-old O\ncheques O\nfor O\na O\ntotal O\nof O\nsix O\nmillion O\nfrancs O\n( O\n$ O\n1.2 O\nmillion O\n) O\nin O\na O\nventilation O\npipe O\n, O\nthe O\nweekly O\nLe B-ORG\nCanard I-ORG\nEnchaine I-ORG\nsaid O\non O\nWednesday O\n. O\n\nA O\nFinance B-ORG\nMinistry I-ORG\nofficial O\nexplained O\nthat O\nthe O\ncheques O\nfor O\ncorporate O\ntax O\npayments O\nhad O\nbeen O\nsucked O\ninto O\nthe O\nventilation O\nsystem O\n, O\nthe O\nweekly O\nreported O\n. O\n\nThe O\ncompanies O\nhad O\nbeen O\ncontacted O\nat O\nthe O\ntime O\nand O\nhad O\nnot O\nbeen O\nfined O\nfor O\nfailing O\nto O\npay O\n, O\nthe O\nofficial O\nsaid O\n. O\n\n-DOCSTART- O\n\nSwiss B-MISC\nbond O\nmarket O\nclosing O\nreport O\n. O\n\nZURICH B-LOC\n1996-08-28 O\n\nSwiss B-MISC\nbonds O\nended O\nmostly O\nhigher O\nin O\ngenerally O\nquiet O\nactivity O\n, O\nwith O\nthe O\nSeptember O\nconfederate O\nbond O\nfutures O\ncontract O\nholding O\njust O\nabove O\n113.00 O\n. O\n\n\" O\nToday O\nwas O\nvery O\nquiet O\nafter O\na O\nlot O\nof O\nactivity O\non O\nTuesday O\n, O\n\" O\nsaid O\none O\nSwiss B-MISC\nbond O\nfutures O\ntrader O\n. O\n\nHe O\nsaid O\nthe O\nmarket O\nbegan O\nstrong O\n, O\ngave O\nup O\nsome O\ngains O\nat O\nmidday O\nand O\nthen O\nwas O\nable O\nto O\nrecover O\nback O\nat O\nthe O\nclose O\n, O\nbut O\nall O\non O\nlight O\nvolume O\n. O\n\nIn O\nthe O\nprimary O\nmarket O\n, O\nEksportfinans B-ORG\nand O\nSuedwest B-ORG\nLB I-ORG\nlaunched O\nissues O\nfor O\n100 O\nmillion O\nand O\n300 O\nmillion O\nSwiss B-MISC\nfrancs O\n, O\nrespectively O\n. O\n\nEksportfinans B-ORG\n' O\nseven-year O\nissue O\nwas O\nquoted O\nat O\na O\nyield O\nof O\n3.98 O\npercent O\n, O\nand O\nSuedwest B-ORG\nLB I-ORG\n's O\nfive-year O\nissue O\nwas O\nquoted O\nat O\n3.60 O\npercent O\n. O\n\nSwiss B-MISC\nmoney O\nmarket O\nrates O\nremained O\nlower O\nat O\naround O\n1.75 O\npercent O\noffered O\n. O\n\nAs O\nto O\nfundamentals O\n, O\neconomists O\nat O\nCredit B-ORG\nSuisse I-ORG\nsaid O\nthey O\nexpect O\nthe O\ncountry O\n's O\ngross O\ndomestic O\nproduct O\nto O\nbe O\nflat O\nto O\nnegative O\nin O\n1996 O\n, O\nand O\nto O\ngrow O\nonly O\n0.6 O\npercent O\nin O\n1997 O\n. O\n\nThe O\nSwiss B-MISC\ngovernment O\nalso O\nsaid O\nWednesday O\nit O\nhad O\nmade O\nprogress O\nin O\ncutting O\nSwitzerland B-LOC\n's O\nprojected O\nspending O\nfor O\n1997 O\n. O\n\nSwitzerland B-LOC\nreports O\nJuly O\nconsumer O\nprices O\nlater O\nthis O\nweek O\n. O\n\nClosing O\nprices O\nas O\nfollows O\n: O\n\nSept O\nconf O\nbond O\nup O\n12 O\nat O\n113.02 O\n. O\n\nSept O\ncomi O\nmedium-term O\nbond O\nup O\nthree O\nat O\n109.45 O\n. O\n\nSept O\nEuro B-MISC\nSwiss I-MISC\nfrancs O\nup O\nthree O\nat O\n97.82 O\n. O\n\n-- O\nCash O\n: O\n\n4-1/2 O\nApr O\n2006 O\nbond O\n101.80 O\n/ O\n90 O\nyield O\n4.252 O\npct O\n\n-- O\nZurich B-ORG\nEditorial I-ORG\n, O\n+41 O\n1 O\n631 O\n7340 O\n\n-DOCSTART- O\n\nAnti-Bhutto B-MISC\nrally O\ndraws O\nabout O\n8,000 O\nin O\nKarachi B-LOC\n. O\n\nKARACHI B-LOC\n, O\nPakistan B-LOC\n1996-08-28 O\n\nAbout O\n8,000 O\nprotesters O\nmarched O\nthrough O\nKarachi B-LOC\non O\nWednesday O\ndemanding O\nthe O\nremoval O\nof O\nPakistani B-MISC\nPrime O\nMinister O\nBenazir B-PER\nBhutto I-PER\n, O\nwitnesses O\nsaid O\n. O\n\n\" O\nFrom O\nhere O\nwe O\nwill O\nmarch O\nto O\nIslamabad B-LOC\nand O\nby O\nGod B-PER\nwe O\nwill O\nnot O\nlet O\nBenazir B-PER\nand O\n( O\nBhutto B-PER\n's O\nhusband O\nAsif B-PER\nAli I-PER\n) O\nZardari B-PER\nescape O\njustice O\n, O\n\" O\nNawaz B-PER\nSharif I-PER\n, O\nleader O\nof O\nthe O\nmain O\nopposition O\nPakistan B-ORG\nMuslim I-ORG\nLeague I-ORG\ntold O\na O\nrally O\norganised O\nby O\na O\n16-party O\nalliance O\n. O\n\nSharif B-PER\naccused O\nBhutto B-PER\nof O\ncorruption O\nand O\nnepotism O\n, O\ncharges O\nshe O\nhas O\ndenied O\nin O\nthe O\npast O\n. O\n\nWitnesses O\nsaid O\nprotesters O\ncarrying O\ncolourful O\nparty O\nflags O\nwalked O\nfor O\nseveral O\nmiles O\n, O\nchanting O\nanti-government O\nslogans O\n. O\n\nThe O\nevent O\nwas O\npart O\nof O\nan O\nopposition O\ncampaign O\nlaunched O\non O\nAugust O\n14 O\n, O\nPakistan B-LOC\n's O\nindependence O\nday O\n. O\n\nSharif B-PER\nsaid O\nsimilar O\nrallies O\nwould O\nbe O\nheld O\nin O\nthe O\nBalochistan B-LOC\nprovincial O\ncapital O\nQuetta B-LOC\nand O\nthe O\nPunjab B-LOC\nprovincial O\ncapital O\nLahore B-LOC\nbefore O\nan O\nopposition O\nmarch O\non O\nthe O\ncapital O\nIslamabad B-LOC\n. O\n\n\" O\nI O\npromise O\nthe O\npeople O\nof O\nKarachi B-LOC\nthat O\nthose O\nresponsible O\nfor O\nthe O\nextra-judicial O\nkilling O\nof O\ninnocent O\nyouths O\nwould O\nnot O\nbe O\nspared O\n, O\n\" O\nSharif B-PER\nsaid O\n. O\n\nKarachi B-LOC\n's O\nethnic O\nMohajir B-ORG\nNational I-ORG\nMovement I-ORG\n( O\nMQM B-ORG\n) O\naccuses O\nthe O\ngovernment O\nof O\nkilling O\nmany O\nof O\nits O\nmilitants O\nin O\ncold O\nblood O\n. O\n\nThe O\ngovernment O\nhas O\ndenied O\nthe O\ncharge O\nand O\nblames O\nthe O\nMQM B-ORG\nfor O\nmuch O\nof O\nthe O\nviolence O\nthat O\nkilled O\n2,000 O\npeople O\nin O\nthe O\ncity O\nlast O\nyear O\n. O\n\nPolitical O\nobservers O\nsaid O\nthe O\nturn-out O\nwas O\ndisappointing O\nfor O\na O\ncity O\nof O\nabout O\n12 O\nmillion O\npeople O\n, O\npossibly O\nindicating O\nthat O\nthe O\nMQM B-ORG\n, O\nalthough O\na O\nmember O\nof O\nthe O\nopposition O\nalliance O\n, O\nhad O\nnot O\nmobilised O\nits O\nsupporters O\nfor O\nthe O\nevent O\n. O\n\nThe O\nturbulent O\nsouthern O\nport O\nhas O\nbeen O\ncalmer O\nthis O\nyear O\n, O\nbut O\npolice O\nsay O\nmore O\nthan O\n300 O\npeople O\nhave O\ndied O\nin O\npolitical O\nunrest O\n. O\n\nThe O\nMQM B-ORG\nspeaks O\nfor O\nUrdu-speaking B-MISC\nMoslems I-MISC\nwho O\nmigrated O\nfrom O\nIndia B-LOC\nat O\nPartition B-LOC\nin O\n1947 O\nand O\ntheir O\ndescendants O\n. O\n\nSharif B-PER\n, O\na O\nformer O\nprime O\nminister O\n, O\nis O\nthe O\nmain O\npolitical O\nrival O\nof O\nBhutto B-PER\n, O\nwho O\ndefeated O\nhim O\nin O\nthe O\nOctober O\n1993 O\nelection O\n. O\n\nHe O\nsaid O\nonly O\nthe O\nremoval O\nof O\nthe O\ngovernment O\nand O\nan O\nearly O\nelection O\ncould O\nsave O\nPakistan B-LOC\nfrom O\ndisaster O\n. O\n\" O\n\nWe O\nwill O\ndislodge O\nthe O\nBhutto B-PER\ngovernment O\n. O\n\nIt O\nis O\na O\nholy O\nwar O\nfor O\nus O\n, O\n\" O\nhe O\nsaid O\n. O\n\nBhutto B-PER\nhas O\nvowed O\nto O\ncomplete O\nher O\nfive-year O\nterm O\n. O\n\n-DOCSTART- O\n\nIndia B-LOC\nACC B-ORG\nApr-Jul O\n' O\n96 O\nsales O\n, O\noutput O\nup O\n. O\n\nBOMBAY B-LOC\n1996-08-28 O\n\nIndia B-LOC\n's O\nleading O\ncement O\nfirm O\nAssociated B-ORG\nCement I-ORG\nCompanies I-ORG\n( O\nACC B-ORG\n) O\nsaid O\non O\nWednesday O\nits O\ncement O\nsales O\nrose O\nto O\n3.1 O\nmillion O\ntonnes O\nin O\nApril-July O\n1996 O\nfrom O\n2.93 O\nmillion O\na O\nyear O\nago O\n. O\n\nACC B-ORG\nChairman O\nNani B-PER\nPalkhivala I-PER\ntold O\nshareholders O\nat O\nthe O\nfirm O\n's O\nannual O\nmeeting O\ncement O\noutput O\nrose O\nto O\n3.14 O\nmillion O\ntonnes O\nin O\nthe O\nfirst O\nquarter O\nof O\n1996/97 O\n( O\nApril-March O\n) O\n, O\nfrom O\n3.01 O\nmillion O\na O\nyear O\nago O\n. O\n\nPalkhivala B-PER\nsaid O\nACC B-ORG\nhad O\nsecured O\ngovernment O\napproval O\nto O\ntake O\nover O\na O\nsick O\ncement O\nfirm O\nwith O\na O\ngrinding O\ncapacity O\nof O\n275,000 O\ntonnes O\nper O\nyear O\n. O\n\" O\n\nWe O\nwill O\ntake O\nit O\nover O\nearly O\nnext O\nmonth O\n, O\n\" O\nhe O\nsaid O\n. O\n\nTalking O\nabout O\nthe O\ncement O\nindustry O\nin O\ngeneral O\n, O\nPalkhivala B-PER\nsaid O\nIndian B-MISC\nproduction O\nrose O\nby O\nabout O\n10 O\npercent O\nin O\n1995/96 O\n. O\n\n\" O\nThe O\nindustry O\nsaw O\ncapacity O\nexpansion O\nof O\nabout O\n13 O\npercent O\nover O\n1994/95 O\nfrom O\n77.79 O\nmillion O\ntonnes O\nto O\n87.45 O\nmillion O\ntonnes O\n, O\n\" O\nPalkhivala B-PER\ntold O\nshareholders O\n. O\n\nHe O\nsaid O\nIndian B-MISC\ncement O\nexports O\ndropped O\nabout O\neight O\npercent O\nfrom O\nthe O\nprevious O\nyear O\nbecause O\nof O\nstiff O\ninternational O\ncompetition O\nand O\ninadequate O\ninfrastructural O\nfacilities O\n. O\n\nACC B-ORG\n's O\nown O\nexport O\nperformance O\nwas O\nmarginally O\nbetter O\nthan O\nin O\n1994/95 O\non O\naccount O\nof O\na O\n36 O\npercent O\nrise O\nin O\nexports O\nto O\nNepal B-LOC\nand O\nthe O\nopening O\nof O\na O\nnew O\nmarket O\n- O\nSri B-LOC\nLanka I-LOC\n, O\nhe O\nsaid O\n. O\n\nDespite O\npower O\nshortages O\n, O\nACC B-ORG\nachieved O\na O\nsatisfactory O\ngrowth O\nin O\nproduction O\nduring O\nthe O\nyear O\nwith O\nthe O\nhelp O\nof O\nits O\npower O\nplants O\n. O\n\nACC B-ORG\nsold O\n9.4 O\nmillion O\ntonnes O\nin O\n1995/96 O\n, O\nretaining O\nits O\ntop O\nposition O\nin O\nthe O\nIndian B-MISC\ncement O\nindustry O\n, O\nPalkhivala B-PER\nsaid O\n. O\n\n-- O\nBombay B-LOC\nnewsroom O\n+91-22-265 O\n9000 O\n\n-DOCSTART- O\n\nBelgium B-LOC\nbank O\nsanctions O\n$ O\n6.5 O\nmln O\nloan O\nto O\nIndia B-LOC\nWSRL B-ORG\n. O\n\nBOMBAY B-LOC\n1996-08-28 O\n\nBelgium B-LOC\n's O\nKredietbank B-ORG\nhas O\napproved O\na O\n$ O\n6.5 O\nmillion O\nloan O\nto O\nIndia B-LOC\n's O\nWelspun B-ORG\nStahl I-ORG\nRohren I-ORG\nLtd I-ORG\n( O\nWSRL B-ORG\n) O\nto O\npart-finance O\nits O\nsubmerged O\narc O\nwelded O\npipes O\nplant O\n, O\nthe O\nIndian B-MISC\ncompany O\nsaid O\nin O\na O\nstatement O\non O\nWednesday O\n. O\n\nThe O\nloan O\nis O\nat O\nLIBOR B-MISC\nplus O\none O\npercent O\n, O\nit O\nsaid O\n. O\n\nThe O\nloan O\n, O\nmaturing O\nin O\nsix O\nyears O\n, O\nis O\nguaranteed O\nby O\nIndusind B-ORG\nBank I-ORG\nfor O\n$ O\n3.5 O\nmillion O\nand O\nby O\nUTI B-ORG\nBank I-ORG\nfor O\n$ O\n3 O\nmillion O\n, O\nit O\nsaid O\n. O\n\nThe O\nWSRL B-ORG\nplant O\n, O\nlocated O\nin O\nthe O\nwestern O\nIndian B-MISC\nstate O\nof O\nGujarat B-LOC\n, O\nwill O\nhave O\na O\ncapacity O\nto O\nmanufacture O\n175,000 O\ntonnes O\nper O\nannum O\nof O\nlongitudinal O\npipes O\nand O\n25,000 O\ntonnes O\nper O\nannum O\nof O\nspiral O\nwelded O\npipes O\n, O\nthe O\nstatement O\nsaid O\n. O\n\nThe O\nlongitudinal O\npipes O\nplant O\nis O\nexpected O\nto O\nbe O\ncomplete O\nby O\nthe O\nsecond O\nquarter O\nof O\nSeptember O\n1997 O\nand O\nthe O\nsaw O\narc O\nwelded O\npipes O\nplant O\nby O\nSeptember O\n1996 O\n, O\nit O\nsaid O\n. O\n\nWSRL B-ORG\nis O\npart O\nof O\nthe O\nWelspun B-ORG\ngroup O\nwhich O\nhas O\na O\npresence O\nin O\nthe O\ncotton O\nyarn O\n, O\nterry O\ntowels O\nand O\npolyester O\nyarn O\nindustry O\n, O\nthe O\nstatement O\nsaid O\n. O\n\n-- O\nBombay B-LOC\nnewsroom O\n+91-22-265 O\n9000 O\n\n-DOCSTART- O\n\nIndia B-LOC\nfishermen O\nsay O\nforced O\nto O\ncarry O\nTamil B-MISC\nrefugees O\n. O\n\nP.V. B-PER\nKrishnamoorthy I-PER\n\nRAMESWARAM B-LOC\n, O\nIndia B-LOC\n1996-08-28 O\n\nIndian B-MISC\nfishermen O\nsaid O\non O\nWednesday O\nthey O\nhad O\nbeen O\nforced O\nat O\ngunpoint O\nto O\nferry O\nrefugees O\nfleeing O\nthe O\nethnic O\nwar O\nin O\nSri B-LOC\nLanka I-LOC\nto O\nIndia B-LOC\n, O\nas O\na O\nprotest O\nstrike O\nby O\nmore O\nthan O\n30,000 O\nfishermen O\nentered O\nits O\nninth O\nday O\n. O\n\n\" O\nThere O\nis O\nlittle O\nwe O\ncan O\ndo O\nwhen O\nat O\nmid-sea O\n. O\n\nThe O\nLTTE B-ORG\n( O\nLiberation B-ORG\nTigers I-ORG\nof I-ORG\nTamil I-ORG\nEelam I-ORG\n) O\naccosts O\nus O\nand O\n, O\nat O\nthe O\npoint O\nof O\na O\ngun O\n, O\nforces O\nus O\nto O\ntake O\nrefugees O\n, O\n\" O\nsaid O\nsenior O\nfishermen O\nleader O\nP. B-PER\nArulanandam I-PER\n. O\n\nSome O\n850 O\nrefugees O\nhave O\nlanded O\nin O\nrecent O\nweeks O\nat O\nthe O\nport O\nof O\nRameswaram B-LOC\nin O\nthe O\nsouthern O\nIndian B-MISC\nstate O\nof O\nTamil B-LOC\nNadu I-LOC\n, O\nhome O\nto O\n50 O\nmillion O\nTamil-speaking B-MISC\npeople O\n, O\nport O\nofficials O\nsay O\n. O\n\nRameswaram B-LOC\nis O\n15 O\nkm O\n( O\n10 O\nmiles O\n) O\noff O\nthe O\ncoast O\nof O\nSri B-LOC\nLanka I-LOC\n. O\n\nState O\nchief O\nminister O\nM. B-PER\nKarunanidhi I-PER\nhas O\npublicly O\nwelcomed O\nthe O\nrefugees O\n, O\nwho O\nare O\nfleeing O\nthe O\n13-year O\nwar O\nbetween O\nTamil B-MISC\nseparatists O\nand O\ngovernment O\ntroops O\nthat O\nColombo B-LOC\nsays O\nhas O\ncost O\n50,000 O\nlives O\n. O\n\nBut O\nthe O\ninflux O\nhas O\ntriggered O\nfears O\nof O\na O\nrepeat O\nof O\nthe O\n1980s O\nwhen O\nsome O\n200,000 O\nrefugees O\nlanded O\nin O\nTamil B-LOC\nNadu I-LOC\n. O\n\nIntelligence O\nofficals O\nsaid O\nmore O\nthan O\n5,000 O\nTamils B-MISC\nwere O\nwaiting O\non O\nthe O\nwestern O\ncoast O\nof O\nSri B-LOC\nLanka I-LOC\nto O\ncross O\ninto O\nIndia B-LOC\n. O\n\nThe O\nIndian B-MISC\ngovernment O\nhas O\nwarned O\nits O\nfishermen O\nthat O\ntheir O\nboats O\nwould O\nbe O\nimpounded O\nif O\nthey O\nwere O\ncaught O\nferrying O\nrefugees O\n. O\n\nThe O\nfishermen O\nwent O\non O\nstrike O\nlast O\nweek O\nto O\nprotest O\nthe O\ngovernment O\n's O\ncancellation O\nof O\nthree O\ntrawlers O\n' O\nfishing O\nlicenses O\nafter O\nthe O\nboats O\nwere O\ncaught O\ncarrying O\nTamil B-MISC\nrefugees O\n. O\n\nAll B-ORG\nFishermen I-ORG\n's I-ORG\nAssociation I-ORG\nsecretary O\nN.J. B-PER\nBose I-PER\nsaid O\nthe O\nstrike O\nwould O\ncontinue O\nindefinitely O\nand O\nthe O\nfishermen O\nwould O\nblock O\nroad O\nand O\nrail O\ntraffic O\nif O\ntheir O\ndemands O\nwere O\nnot O\nmet O\n. O\n\n\" O\nUntil O\nthe O\ngovernment O\nreleases O\nour O\nboats O\nfrom O\nnaval O\ncustody O\nand O\nSri B-MISC\nLankan I-MISC\nnaval O\ncustody O\n, O\nand O\ngives O\nus O\nassurance O\n( O\nit O\nwill O\nnot O\nrevoke O\nlicences O\nof O\nboats O\nferrying O\nrefugees O\n) O\n, O\nwe O\nwill O\nnot O\ncall O\noff O\nour O\nstrike O\n, O\n\" O\nBose B-PER\nsaid O\n. O\n\nLTTE B-ORG\nspokesmen O\ncould O\nnot O\nimmediately O\nbe O\nreached O\nfor O\ncomment O\n, O\nbut O\nSri B-MISC\nLankan I-MISC\nfishermen O\ndenied O\nthat O\nIndians B-MISC\nwere O\nbeing O\ncoerced O\ninto O\ncarrying O\nrefugees O\nacross O\nthe O\nPalk B-LOC\nStrait I-LOC\n. O\n\n\" O\nIndian B-MISC\nfishermen O\ncome O\nright O\nup O\nto O\nPesalai B-LOC\nto O\nfish O\n, O\nand O\nwhen O\nrefugees O\nrequest O\nthem O\nto O\nferry O\nthem O\nacross O\n, O\nthey O\nreadily O\noblige O\n. O\n\nOnly O\nsome O\ntake O\nmoney O\n, O\n\" O\nSri B-MISC\nLankan I-MISC\nboatman O\nChinnathambi B-PER\nsaid O\n. O\n\nArulanandam B-PER\ndenied O\nthe O\nfishermen O\ncharged O\nthe O\nrefugees O\nfor O\npassage O\nto O\nIndia B-LOC\nand O\nsaid O\nit O\nwas O\nunfair O\nto O\npenalise O\nthem O\nfor O\nthe O\nrefugees O\n' O\narrival O\n. O\n\n\" O\nWe O\nhave O\nnot O\ngone O\nto O\nsea O\nsince O\nAugust O\n19 O\n, O\nbut O\nrefugees O\nare O\narriving O\ndaily O\nnevertheless O\n. O\n\nHow O\ncould O\nwe O\nalone O\nbe O\nheld O\nresponsible O\nfor O\nthe O\ninflux O\n? O\n\" O\n\nhe O\nsaid O\n. O\n\nAn O\nIndian B-ORG\nFisheries I-ORG\nDepartment I-ORG\nofficial O\nsaid O\nthe O\ngovernment O\nplanned O\nto O\nurge O\nfishermen O\nnot O\nto O\ncross O\nthe O\ninternational O\nboundary O\nbetween O\nIndia B-LOC\nand O\nSri B-LOC\nLanka I-LOC\n, O\nbut O\nadmitted O\nthis O\nwould O\nbe O\nhard O\nto O\nenforce O\nbecause O\nof O\nSri B-LOC\nLanka I-LOC\n's O\npomfret-rich O\nwaters O\n. O\n\n-DOCSTART- O\n\nIndian B-MISC\ncotton O\ntrade O\nshut O\nfor O\nlocal O\nfestival O\n. O\n\nBOMBAY B-LOC\n1996-08-28 O\n\nIndia B-LOC\n's O\ncotton O\ntrade O\nwas O\nshut O\non O\nWednesday O\nfor O\na O\nlocal O\nreligious O\nfestival O\n, O\ndealers O\nsaid O\n. O\n\nTrading O\nwill O\nresume O\non O\nThursday O\n. O\n\nOn O\nTuesday O\n, O\ncotton O\nprices O\nfell O\non O\nprofit-taking O\nprompted O\nby O\nincreased O\nofferings O\nfrom O\nstate O\nagencies O\n. O\n\n\" O\nExport O\ndeals O\nremained O\nthin O\nand O\nhardly O\na O\nfew O\nthousand O\nbales O\nwere O\ntraded O\nat O\nthe O\nrate O\nof O\n57.50 O\n/ O\n60 O\ncents O\nper O\npound O\n, O\n\" O\none O\nbroker O\nsaid O\n. O\n\n-- O\nBombay B-ORG\nCommodities I-ORG\n+91-22-265 O\n9000 O\n\n-DOCSTART- O\n\nVW B-ORG\nsees O\ngroup O\nnet O\nprofit O\ndoubling O\nin O\nQ3 O\n. O\n\nDRESDEN B-LOC\n, O\nGermany B-LOC\n1996-08-28 O\n\nGerman B-MISC\ncarmaker O\nVolkswagen B-ORG\nAG I-ORG\nsaid O\non O\nWednesday O\nthat O\nit O\nexpected O\ngroup O\nnet O\nprofit O\nto O\ndouble O\nin O\nthe O\nthird O\nquarter O\n. O\n\n\" O\nWe O\nhave O\nbeen O\nseeking O\nto O\ndouble O\nour O\nprofits O\n( O\nduring O\nthe O\nperiod O\n) O\nand O\nwe O\nare O\nconfident O\nof O\ndoing O\nso O\n, O\n\" O\nVW B-ORG\nchief O\nfinancial O\nofficer O\nBruno B-PER\nAdelt I-PER\ntold O\na O\nbriefing O\nas O\npart O\nof O\nthe O\nformal O\nintroduction O\nof O\nthe O\nnew O\nVW B-MISC\nPassat I-MISC\nsedan O\n. O\n\nAdelt B-PER\ndid O\nnot O\ngive O\na O\nconcrete O\nforecast O\n. O\n\nVW B-ORG\nhad O\na O\n1995 O\nthird O\nquarter O\ngroup O\nnet O\nprofit O\nof O\n72 O\nmillion O\nmarks O\n. O\n\nThe O\ngroup O\nreported O\na O\n1996 O\nfirst-half O\ngroup O\nnet O\nprofit O\nof O\n282 O\nmillion O\nmarks O\n. O\n\n-- O\nJohn B-PER\nGilardi I-PER\n, O\nFrankfurt B-ORG\nNewsroom I-ORG\n, O\n+49 O\n69 O\n756525 O\n\n-DOCSTART- O\n\nMILTIADIS B-PER\nEVERT I-PER\nHEADS O\nTO O\nALEXANDROUPOLIS B-LOC\nTHIS O\nWEEKEND O\n. O\n\nATHENS B-LOC\n1996-08-28 O\n\nConservative B-ORG\nNew I-ORG\nDemocracy I-ORG\n( O\nND B-ORG\n) O\nparty O\nleader O\nMiltiadis B-PER\nEvert I-PER\nwill O\nbe O\nhitting O\nthe O\ncampaign O\ntrail O\nand O\nhead O\nto O\nAlexandroupolis B-LOC\nthis O\nweekend O\nto O\nspeak O\nto O\nthe O\ncity O\n's O\nbusinessmen O\non O\nSunday O\nmorning O\n, O\nND B-ORG\nsaid O\n. O\n\nEvert B-PER\nwill O\ndepart O\nfor O\nAlexandroupolis B-LOC\non O\nSaturday O\nafternoon O\n. O\n\nPrime O\nMinister O\nCostas B-PER\nSimitis I-PER\ncriticized O\nEvert B-PER\ntoday O\nfor O\nunleashing O\na O\nseven-point O\neconomic O\npackage O\nthat O\noffers O\ntax O\nrelief O\nto O\nmerchants O\nand O\nother O\nprofessionals O\n, O\nhigher O\npensions O\nto O\nfarmers O\nand O\nsupport O\nfor O\nsmall O\nbusiness O\n. O\n\nThe O\nfinance O\nministry O\nestimated O\nthe O\ncost O\nof O\nND B-ORG\n's O\neconomic O\nmeasures O\nto O\nover O\n600 O\nbillion O\ndrachmas O\nbut O\nND B-ORG\nofficials O\nput O\nthe O\nfigure O\nmuch O\nlower O\nto O\nabout O\n300 O\nbillion O\ndrachmas O\n. O\n\nSimitis B-PER\nblamed O\nND B-ORG\nfor O\nthe O\nlow O\nabsorption O\nrate O\nof O\nEU B-ORG\nfunds O\nand O\nsaid O\nthe O\nsocialists O\nwill O\nincrease O\nfarmers O\n' O\npensions O\n, O\ncombat O\ntax O\nevasion O\nand O\naccelerate O\nGDP O\ngrowth O\nrates O\nto O\n4.0 O\npercent O\nin O\na O\nfew O\nyears O\n. O\n\nFaster O\neconomic O\ngrowth O\nis O\na O\nmajor O\ncomponent O\nof O\nND B-ORG\n's O\neconomic O\nprogramme O\nand O\nEvert B-PER\nhas O\nrepeatedly O\nblamed O\nthe O\nsocialists O\nfor O\nthe O\nslow O\neconomic O\ngrowth O\n. O\n\n-- O\nDimitris B-PER\nKontogiannis I-PER\n, O\nAthens B-ORG\nNewsroom I-ORG\n+301 O\n3311812-4 O\n\n-DOCSTART- O\n\nDow B-MISC\npushes O\nLondon B-LOC\nstocks O\nto O\nnew O\nrecord O\n. O\n\nPeter B-PER\nGriffiths I-PER\n\nLONDON B-LOC\n1996-08-28 O\n\nA O\nfirm O\nstart O\non O\nWall B-LOC\nStreet I-LOC\nhelped O\npush O\nleading O\nLondon B-LOC\nshares O\nto O\na O\nnew O\nrecord O\nhigh O\non O\nWednesday O\nand O\nGerman B-MISC\nstocks O\nclosed O\nfloor O\ntrading O\nup O\nbut O\nthe O\nParis B-LOC\nbourse O\nslipped O\nsharply O\n, O\nhit O\nby O\na O\nweakening O\nfranc O\nand O\nfears O\nof O\nindustrial O\nunrest O\n. O\n\nOn O\nthe O\nforeign O\nexchange O\nmarkets O\n, O\na O\nsurvey O\nindicating O\nweaker O\nthan O\nexpected O\nJapanese B-MISC\nbusiness O\nsentiment O\nboosted O\nthe O\ndollar O\nin O\nearly O\ntrading O\nbut O\nit O\nfailed O\nto O\nbuild O\non O\nits O\ngains O\nagainst O\nthe O\nyen O\nand O\nslipped O\nlower O\nagainst O\nthe O\nmark O\nin O\nquiet O\nafternoon O\ntrade O\n. O\n\nLondon B-LOC\nshares O\n, O\nboosted O\nby O\nWall B-LOC\nStreet I-LOC\n, O\nadded O\nto O\nearly O\ngains O\nwith O\nthe O\nblue O\nchip O\nFTSE B-MISC\n100 I-MISC\nindex O\nhitting O\na O\nnew O\npeak O\nof O\n3921.8 O\nbefore O\ndropping O\nback O\nslightly O\n. O\n\nOne O\nfocus O\nwas O\nBritish B-ORG\nAirways I-ORG\n, O\nwhich O\nrebounded O\nafter O\nfears O\nfaded O\nthat O\nthe O\ncancellation O\nof O\n\" O\nopen O\nskies O\n\" O\ntalks O\nbetween O\nthe O\nU.S. B-ORG\nTransportation I-ORG\nDepartment I-ORG\nand O\nthe O\nBritish B-MISC\ngovernment O\nmay O\njeopardise O\nits O\ntie-up O\nwith O\nAmerican B-ORG\nAirlines I-ORG\n. O\n\nThe O\nconclusion O\nof O\nan O\nopen O\nskies O\nagreement O\nhad O\nbeen O\nmade O\na O\nprerequisite O\nof O\nthe O\nproposed O\nlink-up O\nby O\nthe O\nU.S B-LOC\n. O\n\nBetter-than-expected O\nBritish B-MISC\ntrade O\nfigures O\nhad O\nlittle O\nimpact O\non O\nequities O\n. O\n\nThe O\nnon-EU B-MISC\nJuly O\ntrade O\ndeficit O\ntotalled O\n506 O\nmillion O\nsterling O\n( O\n$ O\n788 O\nmillion O\n) O\nwhile O\nJune O\n's O\nworld O\ndeficit O\nwas O\n1.12 O\nbillion O\npounds O\n. O\n\nForecasts O\nwere O\nfor O\ndeficits O\nof O\n900 O\nmillion O\nsterling O\nand O\n1.4 O\nbillion O\nsterling O\n. O\n\nGerman B-MISC\nshares O\nshed O\nsome O\ngains O\non O\nprofit-taking O\nbut O\nnonetheless O\nended O\nthe O\nfloor O\nsession O\nhigher O\nbuoyed O\nby O\ndemand O\nfor O\nchemical O\nstocks O\nand O\na O\nstable O\ndollar O\n. O\n\nThe O\n30-share O\nDAX B-MISC\nindex O\nclosed O\nat O\n2,563.16 O\npoints O\n, O\nup O\n4.32 O\n. O\n\nHowever O\n, O\nFrench B-MISC\nstocks O\nextended O\nopening O\nlosses O\nto O\nmore O\nthan O\none O\npercent O\nin O\nmorning O\ntrading O\n, O\nfalling O\nthrough O\nthe O\n2000 O\npoint O\nresistance O\nlevel O\non O\nthe O\nmain O\nCAC-40 B-MISC\nindex O\n. O\n\nDealers O\nblamed O\na O\nweakening O\nfranc O\nand O\nworries O\nabout O\nthe O\n1997 O\nbudget O\nand O\npossible O\nautumn O\nstrikes O\n\nLouis B-PER\nViannet I-PER\n, O\nleader O\nof O\nFrance B-LOC\n's O\nCommunist-led B-MISC\nCGT B-ORG\nunion O\n, O\ncriticised O\ngovernment O\nplans O\nfor O\nspending O\ncuts O\nin O\nthe O\n1997 O\nbudget O\non O\nWednesday O\nand O\nwarned O\nof O\nlabour O\nunrest O\nas O\nFrance B-LOC\ngets O\nback O\nto O\nwork O\nafter O\nthe O\nholidays O\n. O\n\nLater O\nin O\nthe O\nday O\n, O\nhelped O\nby O\nthe O\nfirmer O\nWall B-LOC\nStreet I-LOC\nopening O\n, O\nParis B-LOC\nclimbed O\nback O\nto O\nthe O\n2000 O\nlevel O\nbut O\nstill O\nremained O\nwell O\ninto O\nnegative O\nterritory O\n. O\n\nIn O\nforeign O\nexchange O\nthe O\ndollar O\nwas O\ntrading O\nat O\naround O\n108.40 O\nyen O\nin O\nthe O\nEuropean B-MISC\nafternoon O\n, O\nup O\nfrom O\nits O\nEuropean B-MISC\nclose O\non O\nTuesday O\nof O\n107.55 O\nbut O\noff O\nthe O\nday O\n's O\nhighs O\n. O\n\nIt O\nhad O\nbeen O\nboosted O\novernight O\nby O\nthe O\nBank B-ORG\nof I-ORG\nJapan I-ORG\n's O\nquarterly O\ncorporate O\nsurvey O\n, O\nor O\n\" O\ntankan O\n\" O\n, O\nof O\nmajor O\nmanufacturers O\n-- O\nan O\nimportant O\ngauge O\nof O\nbusiness O\nsentiment O\n. O\n\nThe O\nunexpectedly O\nweak O\nfigures O\nconvinced O\nmarkets O\nthat O\nJapanese B-MISC\ninterest O\nrates O\nwould O\nstay O\nat O\nrock-bottom O\nlevels O\n-- O\nweakening O\nthe O\nyen O\n. O\n\nThe O\nJapanese B-MISC\ndiscount O\nrate O\nis O\ncurrently O\nat O\na O\nrecord O\nlow O\nof O\n0.5 O\npercent O\n. O\n\nThe O\nBOJ B-ORG\nsought O\nto O\nput O\nthe O\nbest O\nface O\non O\nthe O\ndata O\nwhich O\ndefied O\neconomists O\n' O\npredictions O\nof O\nimproving O\nsentiment O\nand O\nwas O\nthe O\nfirst O\ndecline O\nin O\nbusiness O\nsentiment O\nin O\na O\nyear O\n. O\n\nA O\nBOJ B-ORG\nspokesman O\nsaid O\n\" O\nthe O\ndoors O\nto O\nthe O\nrecovery O\nhave O\nnot O\nbeen O\nshut O\n... O\n\nthe O\nrecovery O\nis O\nstill O\ncontinuing O\n. O\n\" O\n\nThese O\nremarks O\ngave O\nthe O\nyen O\nsome O\nbackbone O\nand O\nthe O\ndollar O\nfailed O\nto O\nprogress O\nfurther O\n. O\n\n\" O\nThe O\ndollar O\n's O\ngains O\nwere O\nless O\nthan O\nspectacular O\n, O\nsuggesting O\nthat O\nwhile O\nit O\n's O\nlikely O\nto O\nbenefit O\nfrom O\nrevised O\nJapanese B-MISC\nrate O\nexpectations O\n, O\na O\nbreakout O\nfrom O\nthe O\nestablished O\ntrading O\nrange O\ndoes O\nn't O\nappear O\nlikely O\n, O\n\" O\nsaid O\ncurrency O\neconomist O\nKlaus B-PER\nBaader I-PER\n. O\n\nDealers O\nsaid O\nshares O\nwere O\nalso O\naffected O\nby O\na O\nslippage O\nin O\nbond O\nprices O\ndue O\nto O\nlower O\nthan O\nexpected O\nJune O\nindustrial O\nproduction O\n, O\nshowing O\nthe O\neconomy O\nwas O\nstill O\nfaltering O\n. O\n\nCURRENCIES O\nAT O\n1500 O\nGMT B-MISC\n\nThe O\ndollar O\nwas O\nat O\n108.40 O\nyen O\nand O\n1.4765 O\nmarks O\ncompared O\nwith O\nTuesday O\n's O\nEuropean B-MISC\nclose O\nof O\n107.78 O\nyen O\nand O\n1.4779 O\nmarks O\n\nSTOCK O\nMARKETS O\nAT O\n1500 O\nGMT B-MISC\n\nThe O\nFinancial B-MISC\nTimes-Stock I-MISC\nExchange I-MISC\nindex O\nof O\n100 O\nleading O\nBritish B-MISC\nshares O\nhad O\nrisen O\n15 O\npoints O\nto O\n3,920.7 O\n. O\n\nIn O\nParis B-LOC\n, O\nthe O\nCAC-40 B-MISC\nshare O\nindex O\ndropped O\n15.09 O\nto O\n2,002.9 O\n. O\n\nThe O\n30-share O\nDAX B-MISC\nindex O\nin O\nFrankfurt B-LOC\nclosed O\nup O\n4.32 O\nat O\n2,563.16 O\n. O\n\nPRECIOUS O\nMETALS O\n\nGold O\nfixed O\nat O\n$ O\n388.50 O\nversus O\nTuesday O\n's O\nLondon B-LOC\nclose O\nof O\n$ O\n388.55 O\n. O\n\nSilver O\nwas O\nat O\n521.15 O\ncents O\n. O\n\n( O\n$ O\n1=.6421 O\nSterling O\n) O\n\n-DOCSTART- O\n\nAEI B-ORG\n's O\nSpanish B-MISC\noperation O\nwins O\nISO B-MISC\n9002 I-MISC\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nAir B-ORG\nExpress I-ORG\nInternational I-ORG\nsaid O\nin O\na O\nstatement O\nthat O\nSpain B-LOC\nhas O\nbecome O\nthe O\ntwenty-second O\ncountry O\nin O\nits O\nnetwork O\nto O\nachieve O\nISO B-MISC\n9002 I-MISC\nquality O\naccreditation O\n. O\n\nIt O\nadded O\nBureau B-ORG\nVeritas I-ORG\nhas O\naccredited O\nAEI B-ORG\nIberfreight I-ORG\n's O\noffices O\nat O\nAlicante B-LOC\n, O\nBarcelona B-LOC\n, O\nBilbao B-LOC\n, O\nMadrid B-LOC\n, O\nSeville B-LOC\nand O\nValencia B-LOC\nas O\nmeeting O\nthe O\nnecessary O\nstandards O\n. O\n\n-- O\nAir B-ORG\nCargo I-ORG\nNewsroom I-ORG\nTel+44 O\n171 O\n542 O\n7706 O\nFax+44 O\n171 O\n542 O\n5017 O\n\n-DOCSTART- O\n\nArafat B-PER\nsays O\nIsrael B-LOC\ndeclares O\nwar O\non O\nPalestinians B-MISC\n. O\n\nWafa B-PER\nAmr I-PER\n\nRAMALLAH B-LOC\n, O\nWest B-LOC\nBank I-LOC\n1996-08-28 O\n\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\nsaid O\non O\nWednesday O\nthat O\nIsrael B-LOC\nhad O\ndeclared O\nwar O\non O\nthe O\nPalestinians B-MISC\nand O\ncalled O\nfor O\nthe O\nfirst O\ngeneral O\nstrike O\nin O\nthe O\nWest B-LOC\nBank I-LOC\nand O\nGaza B-LOC\nin O\ntwo O\nyears O\n. O\n\n\" O\nWhat O\nhappened O\nconcerning O\ncontinuous O\nviolations O\nand O\ncrimes O\nfrom O\nthis O\nnew O\nIsraeli B-MISC\nleadership O\nmeans O\nthey O\nare O\ndeclaring O\na O\nstate O\nof O\nwar O\nagainst O\nthe O\nPalestinian B-MISC\npeople O\n, O\n\" O\nArafat B-PER\ntold O\nthe O\nPalestinian B-MISC\nlegislature O\n. O\n\nAccusing O\nIsraeli B-MISC\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\nof O\nstupidity O\n, O\nArafat B-PER\nlaunched O\nhis O\nstrongest O\nattack O\non O\nthe O\nright-wing O\ngovernment O\nsince O\nits O\nelection O\nin O\nMay O\n. O\n\nThe O\ntirade O\nwas O\nsparked O\nby O\nIsrael B-LOC\n's O\nannouncement O\non O\nTuesday O\nof O\nplans O\nto O\nexpand O\nthe O\nJewish B-MISC\nsettlement O\nof O\nKiryat B-LOC\nSefer I-LOC\nand O\nits O\ndemolishing O\nof O\na O\ncommunity O\ncentre O\nin O\nArab B-LOC\nEast I-LOC\nJerusalem I-LOC\n. O\n\n\" O\nIsrael B-LOC\nhas O\nstarted O\nthe O\nwar O\non O\nJerusalem B-LOC\n. O\n\nThey O\nare O\nidiots O\nto O\nhave O\nstarted O\nthe O\nJerusalem B-LOC\nbattle O\n, O\n\" O\nArafat B-PER\nsaid O\nin O\nArabic B-MISC\n. O\n\" O\n\nThere O\nwill O\nbe O\nno O\nPalestinian B-MISC\nstate O\nwithout O\nJerusalem B-LOC\n. O\n\nNetanyahu B-PER\nshould O\nknow O\nhe O\nis O\nstupid O\nto O\nhave O\nstarted O\nthis O\nbattle O\n. O\n\" O\n\nArafat B-PER\ncalled O\nfor O\na O\ngeneral O\nstrike O\n\" O\nfor O\nJerusalem B-LOC\n\" O\non O\nThursday O\nin O\nall O\nof O\nthe O\nWest B-LOC\nBank I-LOC\nand O\nGaza B-LOC\nStrip I-LOC\n. O\n\nThere O\nhas O\nnot O\nbeen O\na O\njoint O\nshutdown O\nthere O\nsince O\nMay O\n1994 O\nwhen O\nIsraeli B-MISC\ntroops O\nbegan O\nwithdrawing O\nunder O\nan O\ninterim O\nself-rule O\nagreement O\nsigned O\nin O\n1993 O\n. O\n\nThe O\nstrike O\nwill O\nhave O\nlittle O\neffect O\non O\nthe O\nIsraeli B-MISC\neconomy O\nwhile O\nhurting O\nPalestinian B-MISC\nmerchants O\nin O\nEast B-LOC\nJerusalem I-LOC\nand O\nBethlehem B-LOC\nwho O\ncater O\nto O\nthe O\ntourist O\ntrade O\n. O\n\nSome O\n25,000 O\nPalestinian B-MISC\nlabourers O\nare O\nlikely O\nto O\nstay O\naway O\nfrom O\ntheir O\njobs O\n, O\nmainly O\nin O\nconstruction O\n, O\nin O\nIsrael B-LOC\n. O\n\nBut O\nPalestinians B-MISC\n, O\nonce O\nthe O\nbackbone O\nof O\nthe O\nbuilding O\nindustry O\n, O\nhave O\nbeen O\nlargely O\nreplaced O\nby O\nlabourers O\nfrom O\nRomania B-LOC\nand O\nChina B-LOC\n. O\n\n\" O\nOn O\nFriday O\n, O\nall O\nMoslems B-MISC\n, O\nincluding O\nPalestinians B-MISC\nin O\nIsrael B-LOC\n... O\n\nwill O\ngo O\nto O\n( O\nJerusalem B-LOC\n's O\n) O\nAl-Aqsa B-LOC\nmosque O\nand O\npray O\n. O\n\nJews B-MISC\nand O\nChristians B-MISC\nwho O\ndo O\nnot O\npray O\nshould O\naccompany O\nthem O\nand O\nstand O\nbehind O\nthem O\n, O\n\" O\nArafat B-PER\nsaid O\n. O\n\nOfficials O\nin O\nNetanyahu B-PER\n's O\noffice O\nwere O\nnot O\nimmediately O\navailable O\nfor O\ncomment O\non O\nArafat B-PER\n's O\nremarks O\n. O\n\nIsraeli B-MISC\ntravel O\nrestrictions O\n, O\nimposed O\nafter O\nbombings O\nby O\nMoslem B-MISC\nmilitants O\nin O\nFebruary O\nand O\nMarch O\n, O\nban O\nmost O\nof O\nthe O\ntwo O\nmillion O\nArabs B-MISC\nin O\nthe O\nWest B-LOC\nBank I-LOC\nand O\nGaza B-LOC\nfrom O\nentering O\nJerusalem B-LOC\n. O\n\nNetanyahu B-PER\n, O\nwho O\nopposes O\ntrading O\noccupied O\nland O\nfor O\npeace O\n, O\nmade O\nJerusalem B-LOC\na O\ncentral O\nissue O\nin O\nhis O\nelection O\ncampaign O\n, O\naccusing O\nLabour B-ORG\nPrime O\nMinister O\nShimon B-PER\nPeres I-PER\nof O\nplanning O\nto O\nhand O\ncontrol O\nof O\nthe O\nArab B-MISC\neastern O\npart O\nof O\nthe O\ncity O\nto O\nthe O\nPalestinians B-MISC\n. O\n\nIsrael B-LOC\ncaptured O\nEast B-LOC\nJerusalem I-LOC\nin O\nthe O\n1967 O\nMiddle B-LOC\nEast I-LOC\nwar O\nand O\nclaims O\nboth O\nhalves O\nof O\nthe O\ncity O\nas O\nits O\ncapital O\n. O\n\nThe O\nPLO B-ORG\nwants O\nEast B-LOC\nJerusalem I-LOC\nas O\nthe O\ncapital O\nof O\na O\nfuture O\nPalestinian B-MISC\nstate O\n. O\n\nIn O\nhis O\nspeech O\nto O\nthe O\ncrowded O\nlegislature O\n, O\nArafat B-PER\nsignalled O\nhe O\nwas O\nnot O\nabandoning O\ndiplomacy O\nalthough O\n\" O\nalarm O\nbells O\nare O\nringing O\n\" O\n. O\n\nHe O\nunexpectedly O\nbroke O\noff O\nhis O\naddress O\nto O\ntake O\na O\ntelephone O\ncall O\nfrom O\nU.S. B-LOC\nMiddle I-LOC\nEast I-LOC\nenvoy O\nDennis B-PER\nRoss I-PER\n, O\nwho O\nheld O\ntalks O\nin O\nParis B-LOC\non O\nTuesday O\nwith O\nIsraeli B-MISC\nand O\nEgyptian B-MISC\nofficials O\n. O\n\nWhen O\nArafat B-PER\nreturned O\nto O\nthe O\npodium O\n, O\nhe O\nsaid O\nsenior O\nPLO B-ORG\nnegotiator O\nMahmoud B-PER\nAbbas I-PER\n, O\nbetter O\nknown O\nas O\nAbu B-PER\nMazen I-PER\n, O\nand O\nNetanyahu B-PER\naide O\nDore B-PER\nGold I-PER\ncould O\nmeet O\non O\nThursday O\n. O\n\nHe O\nquoted O\nRoss B-PER\nas O\ntelling O\nhim O\n: O\n\" O\nThe O\nimportant O\nthing O\nis O\nthe O\nIsraelis B-MISC\nare O\nprepared O\nto O\nmove O\n. O\n\" O\n\nArafat B-PER\nsaid O\nhe O\nreplied O\n: O\n\" O\nis O\nthis O\nlike O\ntheir O\nprevious O\npromises O\n? O\n\" O\n\n\" O\nNo O\n, O\nthey O\nhave O\ngood O\nintentions O\n, O\n\" O\nArafat B-PER\nquoted O\nRoss B-PER\nas O\nsaying O\n. O\n\nPalestinians B-MISC\nhave O\nbeen O\npressing O\nIsrael B-LOC\nto O\ncarry O\nout O\na O\nlong-delayed O\npartial O\ntroop O\npullout O\nfrom O\nthe O\nflashpoint O\nWest B-LOC\nBank I-LOC\ncity O\nof O\nHebron B-LOC\nagreed O\nby O\nthe O\nprevious O\nLabour B-ORG\ngovernment O\n. O\n\nThe O\nIsraeli B-MISC\ngovernment O\nis O\nstudying O\nredeployment O\nplans O\nsubmitted O\nby O\nDefence O\nMinister O\nYitzhak B-PER\nMordechai I-PER\nwhich O\nare O\nlikely O\nto O\ndemand O\na O\nwider O\nthan O\nagreed O\narmy O\npresence O\nin O\nHebron B-LOC\n. O\n\n-DOCSTART- O\n\nTurkey B-LOC\n's O\nCiller B-PER\nto O\nhold O\ntalks O\nin O\nJordan B-LOC\n. O\n\nANKARA B-LOC\n1996-08-28 O\n\nTurkish B-MISC\nForeign O\nMinister O\nTansu B-PER\nCiller I-PER\nwill O\nvisit O\nJordan B-LOC\non O\nSeptember O\n3 O\non O\nher O\nfirst O\ntrip O\nabroad O\nsince O\nshe O\ntook O\noffice O\nin O\nJune O\n, O\nForeign B-ORG\nMinistry I-ORG\nspokesman O\nOmer B-PER\nAkbel I-PER\nsaid O\non O\nWednesday O\n. O\n\n\" O\nThe O\ntwo-day O\nvisit O\nwill O\ntake O\nplace O\nat O\nthe O\ninvitation O\nof O\nJordanian B-MISC\nPrime O\nMinister O\nAbdul-Karim B-PER\nal-Kabariti I-PER\n, O\n\" O\nhe O\ntold O\nreporters O\n. O\n\nHe O\nsaid O\nTurkey B-LOC\nconsidered O\nJordan B-LOC\na O\nsuitable O\ncountry O\nwith O\nwhich O\nto O\ncooperate O\non O\nMiddle B-LOC\nEast I-LOC\nmatters O\n. O\n\nBilateral O\nrelations O\nand O\nthe O\nMiddle B-LOC\nEast I-LOC\npeace O\nprocess O\nwould O\nbe O\non O\nthe O\ntable O\nduring O\nthe O\nvisit O\n, O\nAkbel B-PER\nsaid O\n. O\n\nTurkish B-MISC\nPrime O\nMinister O\nNecmettin B-PER\nErbakan I-PER\nvisited O\nmainly O\nMoslem B-MISC\ncountries O\n, O\nincluding O\nIran B-LOC\n, O\nduring O\na O\n10-day O\ntour O\nearlier O\nin O\nAugust O\n. O\n\n-DOCSTART- O\n\nItalian B-MISC\nprime O\nminister O\nto O\nvisit O\nTurkey B-LOC\n. O\n\nANKARA B-LOC\n1996-08-28 O\n\nItalian B-MISC\nPrime O\nMinister O\nRomano B-PER\nProdi I-PER\nwill O\npay O\na O\none-day O\nworking O\nvisit O\nto O\nTurkey B-LOC\non O\nSeptember O\n3 O\n, O\nthe O\nTurkish B-MISC\nForeign B-ORG\nMinistry I-ORG\nsaid O\non O\nWednesday O\n. O\n\n\" O\nBoth O\ncountries O\n' O\ngovernments O\nwere O\nformed O\nrecently O\n. O\n\nThis O\nvisit O\nwill O\ncreate O\na O\ndirect O\ncontact O\nopportunity O\nfor O\nthe O\ntwo O\nparties O\nto O\nexpress O\ntheir O\nviews O\n, O\n\" O\nspokesman O\nOmer B-PER\nAkbel I-PER\ntold O\na O\nnews O\nbriefing O\n. O\n\nThe O\nItalian B-MISC\nprime O\nminister O\n, O\nin O\noffice O\nsince O\nMay O\n18 O\n, O\nwill O\nbe O\nthe O\nfirst O\nWestern B-MISC\nleader O\nto O\nmeet O\nIslamist B-MISC\nPrime O\nMinister O\nNecmettin B-PER\nErbakan I-PER\nsince O\nhe O\ncame O\nto O\npower O\non O\nJune O\n28 O\n. O\n\nProdi B-PER\nwill O\nalso O\nmeet O\nPresident O\nSuleyman B-PER\nDemirel I-PER\nand O\nForeign O\nMinister O\nTansu B-PER\nCiller I-PER\n, O\nAkbel B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nTurkey B-LOC\nsays O\n25 O\nKurd B-MISC\nrebels O\nkilled O\nin O\nclashes O\n. O\n\nDIYARBAKIR B-LOC\n, O\nTurkey B-LOC\n1996-08-28 O\n\nTurkish B-MISC\ntroops O\nkilled O\n25 O\nKurdish B-MISC\nrebels O\nin O\nrecent O\nclashes O\nin O\nthe O\neast O\nof O\nthe O\ncountry O\n, O\nsecurity O\nofficials O\nsaid O\non O\nWednesday O\n. O\n\nThe O\nemergency O\nrule O\ngovernor O\n's O\noffice O\nsaid O\nin O\na O\nstatement O\nthat O\n10 O\nrebels O\nfrom O\nthe O\nKurdistan B-ORG\nWorkers I-ORG\nParty I-ORG\n( O\nPKK B-ORG\n) O\nwere O\nkilled O\nin O\nfighting O\nin O\nTunceli B-LOC\nprovince O\n. O\n\nSoldiers O\nkilled O\nnine O\nmore O\nPKK B-ORG\nguerrillas O\nin O\nSirnak B-LOC\nprovince O\nand O\nsix O\nin O\nHakkari B-LOC\n. O\n\nThe O\nstatement O\ndid O\nnot O\nreport O\nany O\nmilitary O\ncasualties O\nand O\ndid O\nnot O\nsay O\nexactly O\nwhen O\nthe O\nclashes O\ntook O\nplace O\n. O\n\nOver O\n20,000 O\npeople O\nhave O\nbeen O\nkilled O\nin O\nthe O\nPKK B-ORG\n's O\nfight O\nfor O\nindependence O\nor O\nautonomy O\nin O\nsoutheastern O\nTurkey B-LOC\n. O\n\n-DOCSTART- O\n\nIsrael B-LOC\n's O\nLevy B-PER\nto O\nmeet O\nMubarak B-PER\nin O\nEgypt B-LOC\n. O\n\nJERUSALEM B-LOC\n1996-08-28 O\n\nIsraeli B-MISC\nForeign O\nMinister O\nDavid B-PER\nLevy I-PER\nwill O\nvisit O\nEgypt B-LOC\nthis O\nSunday O\nfor O\ntalks O\nwith O\nPresident O\nHosni B-PER\nMubarak I-PER\n, O\nthe O\nForeign B-ORG\nMinistry I-ORG\nsaid O\non O\nWednesday O\n. O\n\nThe O\ntrip O\nwill O\nbe O\nLevy B-PER\n's O\nfirst O\nto O\nan O\nArab B-MISC\nstate O\nas O\na O\nminister O\nin O\nPrime O\nMinister O\nBenjamin B-PER\nNetanyahu I-PER\n's O\ngovernment O\n. O\n\n-DOCSTART- O\n\nFSA B-ORG\nqualifies O\nfive O\nmuni O\nbond O\nissues O\nfor O\ninsurance O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nFinancial B-ORG\nSecurity I-ORG\nAssurance I-ORG\nsaid O\nWednesday O\nit O\nqualified O\nfor O\nbond O\ninsurance O\nthe O\nfollowing O\nfive O\nmunicipal O\nissues O\nscheduled O\nfor O\ncompetitive O\nsale O\ntoday O\n: O\n\n-- O\nParis B-LOC\nSchool O\nDistrict O\nNo O\n7 O\n, O\nArk B-LOC\n. O\n\n, O\n$ O\n2.44 O\nmillion O\nrefunding O\nbonds O\n. O\n\n-- O\nSt B-LOC\nAnsgar I-LOC\nCommunity O\nSchool O\nDistrict O\n, O\nIowa B-LOC\n, O\n$ O\n3.334 O\nmillion O\ngeneral O\nobligation O\nschool O\nbonds O\n. O\n\n-- O\nAvalon B-LOC\nBorough I-LOC\n, O\nN.J. B-LOC\n, O\n$ O\n11.4 O\nmillion O\nGOs O\n. O\n\n-- O\nSeaford B-LOC\nUnion I-LOC\nFree O\nSchool O\nDistrict O\n, O\nN.Y. B-LOC\n, O\n$ O\n5 O\nmillion O\nschool O\nbonds O\n. O\n\n-- O\nAkron B-LOC\n, O\nOhio B-LOC\n, O\n$ O\n6.31 O\nmillion O\nimprovement O\nbonds O\n. O\n\n-- O\nU.S. B-ORG\nMunicipal I-ORG\nDesk I-ORG\n, O\n212-859-1650 O\n\n-DOCSTART- O\n\nColo B-LOC\n. I-LOC\n\ntaxable O\nhealth O\ndeal O\nrated O\nAa2 O\n/ O\nVMIG-1 O\n- O\nMoody B-ORG\n's I-ORG\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nMoody B-ORG\n's I-ORG\nInvestors I-ORG\nService I-ORG\n- O\n\nRating O\nAnnouncement O\nAs O\nof O\n08/26/96 O\n. O\n\nIssuer O\n: O\nColorado B-ORG\nHealth I-ORG\nFac I-ORG\n. I-ORG\n\nAuth B-ORG\n. I-ORG\n\nNational B-ORG\n\nBenevolent B-ORG\nAssoc I-ORG\n. I-ORG\n\n- O\nColorado B-ORG\nChristian I-ORG\nHome I-ORG\n\nProj O\n. O\n\nSeries O\n1996 O\nB O\nTaxable O\n\nState O\n: O\nCO B-LOC\n\nRating O\n: O\nAa2 O\n/ O\nVMIG O\n1 O\n\nSale O\nAmount O\n: O\n4,300,000 O\n\nExpected O\nSale O\nDate O\n: O\n08/26/96 O\n\n-DOCSTART- O\n\nLamm B-PER\nwill O\nnot O\nendorse O\nPerot B-PER\nfor O\nReform B-MISC\nticket-CNN I-MISC\n. O\n\nWASHINGTON B-LOC\n1996-08-27 O\n\nFormer O\nColorado B-LOC\nDemocratic B-MISC\nGov O\n. O\n\nRichard B-PER\nLamm I-PER\nhas O\ndecided O\nnot O\nto O\nendorse O\nRoss B-PER\nPerot I-PER\nas O\nthe O\npresidential O\ncandidate O\nof O\nthe O\nReform B-ORG\nParty I-ORG\n, O\nCNN B-ORG\nreported O\nlate O\nTuesday O\n. O\n\nCNN B-ORG\nquoted O\naides O\nand O\nfamily O\nmembers O\nas O\nsaying O\nLamm B-PER\n, O\nwho O\ncompeted O\nwith O\nPerot B-PER\nto O\nhead O\nthe O\nticket O\nfor O\nPerot B-PER\n's O\nparty O\n, O\nhad O\ntold O\nthem O\nhe O\nwould O\ndefinitely O\nnot O\nendorse O\nPerot B-PER\n, O\nbut O\nthey O\ndid O\nnot O\nknow O\nwhether O\nhe O\nwould O\nendorse O\nanother O\ncandidate O\n. O\n\nAn O\nannouncement O\nwas O\nplanned O\nin O\nChicago B-LOC\nWednesday O\n. O\n\nLamm B-PER\n, O\n60 O\n, O\nis O\na O\nthree-term O\nColorado B-LOC\ngovernor O\nwho O\nleft O\noffice O\nin O\n1987 O\nand O\nvied O\nfor O\nthe O\nReform B-ORG\nParty I-ORG\nnomination O\nafter O\nbecoming O\ndisillusioned O\nwith O\nboth O\nthe O\nDemocratic B-MISC\nand O\nRepublican B-MISC\nparties O\n. O\n\nLamm B-PER\nis O\na O\nfriend O\nof O\nPresident O\nClinton B-PER\nand O\nsupported O\nhim O\nin O\nthe O\n1992 O\nelection O\n. O\n\nPerot B-PER\nwon O\nhis O\nparty O\n's O\nofficial O\nnomination O\nas O\nits O\npresidential O\ncandidate O\nin O\na O\nsecret O\nballot O\nearlier O\nthis O\nmonth O\n. O\n\n-DOCSTART- O\n\nRESEARCH O\nALERT O\n- O\nCareer B-ORG\nHorizons I-ORG\nsaid O\ncut O\n. O\n\n-- O\nDonaldson B-ORG\nLufkin I-ORG\n& I-ORG\nJenrette I-ORG\ncut O\nits O\nrating O\non O\nCareer B-ORG\nHorizons I-ORG\nInc I-ORG\nto O\nmarket O\nperform O\nfrom O\noutperform O\n, O\naccording O\nto O\nmarket O\nsources O\n. O\n\n-- O\nFurther O\ndetails O\nwere O\nnot O\nimmediately O\navailable O\n. O\n\n-- O\nThe O\nstock O\nwas O\nup O\n3/4 O\nat O\n35-7/8 O\n. O\n\n-DOCSTART- O\n\nNorthern B-ORG\nStates I-ORG\nPower I-ORG\nCo I-ORG\nsets O\npayout O\n. O\n\nMINNEAPOLIS B-LOC\n1996-08-28 O\n\nQuarterly O\n\nLatest O\nPrior O\n\nAmount O\n$ O\n0.69 O\n$ O\n0.69 O\n\nPay O\nOct O\n20 O\n\nRecord O\nOct O\n1 O\n\n-- O\nChicago B-LOC\nnewsdesk O\n312 O\n408-8787 O\n\n-DOCSTART- O\n\nUS B-LOC\ninvestors O\nmull O\nappeal O\nof O\nLloyd B-ORG\n's I-ORG\ndecision O\n. O\n\nPatricia B-PER\nVowinkel I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-27 O\n\nU.S. B-LOC\ninvestors O\nin O\ntroubled O\nLloyd B-ORG\n's I-ORG\nof I-ORG\nLondon I-ORG\nwere O\nconsidering O\nlate O\non O\nTuesday O\nwhether O\nto O\nappeal O\na O\nU.S. B-LOC\ncourt O\ndecision O\nin O\nfavour O\nof O\nLloyd B-ORG\n's I-ORG\nand O\npledged O\nto O\ncontinue O\npursuing O\nother O\nlegal O\nactions O\n. O\n\nA O\nU.S. B-LOC\nappeals O\ncourt O\non O\nTuesday O\ngave O\nLloyd B-ORG\n's I-ORG\na O\nreprieve O\n, O\nthrowing O\nout O\nan O\ninjunction O\nthat O\nthe O\ninsurance O\ngiant O\nsaid O\ncould O\nhave O\nled O\nto O\nits O\ncollapse O\n. O\n\nA O\nlower O\ncourt O\nissued O\nthe O\ninjunction O\non O\nFriday O\nand O\nordered O\nLloyd B-ORG\n's I-ORG\nto O\ngive O\ninvestors O\n, O\nknown O\nas O\nNames B-MISC\n, O\nmore O\ninformation O\nbefore O\nrequiring O\nthem O\nto O\ndecide O\nwhether O\nto O\naccept O\na O\nsettlement O\noffer O\nas O\npart O\nof O\na O\nreorganisation O\nplan O\n. O\n\n\" O\nMy O\nprediction O\nis O\nthat O\nthe O\nNames B-MISC\nwill O\nappeal O\n, O\n\" O\nsaid O\nKenneth B-PER\nChiate I-PER\n, O\na O\nU.S. B-LOC\nName B-MISC\nand O\na O\nchief O\nnegotiator O\nfor O\nthe O\nAmerican B-ORG\nNames I-ORG\nAssociation I-ORG\n. O\n\n\" O\nAt O\nthis O\npoint O\n, O\nit O\nis O\na O\nsufficiently O\nimportant O\ndecision O\nthat O\nI O\n'm O\nconfident O\nthat O\nthey O\nwill O\nappeal O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nBut O\nto O\nsay O\nthat O\nthey O\ndefinitely O\nwill O\nwould O\nbe O\npremature O\nuntil O\nwe O\ndetermine O\nwhat O\nthe O\nexact O\nbasis O\nfor O\nthe O\ncourt O\n's O\nruling O\nis O\n. O\n\" O\n\nUnder O\nthe O\nreorganisation O\nplan O\n, O\nLloyd B-ORG\n's I-ORG\nplans O\nto O\nreinsure O\nits O\nmassive O\nliabilities O\ninto O\na O\nnew O\ncompany O\ncalled O\nEquitas B-ORG\n. O\n\nThe O\narrangement O\ncalls O\nfor O\ninvestors O\nto O\nmake O\nadditional O\npayments O\nto O\nfund O\nEquitas B-ORG\nbut O\nalso O\nprovides O\nthem O\nwith O\n3.2 O\nbillion O\nstg O\nin O\ncompensation O\nto O\nhelp O\nreduce O\ntheir O\nprior O\noutstanding O\nliabilities O\n. O\n\nThe O\nNames B-MISC\nhad O\nbeen O\nscheduled O\nto O\ndecide O\nwhether O\nto O\naccept O\nor O\nreject O\nthe O\noffer O\nby O\n1100 O\nGMT B-MISC\nWednesday O\n, O\nbut O\nLloyd B-ORG\n's I-ORG\nchairman O\nDavid B-PER\nRowland I-PER\nsaid O\non O\nTuesday O\nthe O\noffer O\nwould O\nbe O\nextended O\n. O\n\nAt O\nleast O\neight O\nU.S. B-LOC\nstates O\nhave O\nstill O\nsome O\nform O\nof O\nlitigation O\npending O\n, O\nsaid O\nJohn B-PER\nHead I-PER\n, O\nspokesman O\nfor O\nthe O\nAssociation B-ORG\nof I-ORG\nLloyd I-ORG\n's I-ORG\nState O\nChairmen O\n, O\na O\ngroup O\nrepresenting O\nU.S. B-LOC\nNames B-MISC\n. O\n\n\" O\nIt O\ngoes O\nwithout O\nsaying O\nthat O\nwe O\n're O\nrather O\ndisappointed O\n, O\n\" O\nHead B-PER\nsaid O\nof O\nthe O\ndecision O\nby O\nthe O\nU.S. B-ORG\nCourt I-ORG\nof I-ORG\nAppeals I-ORG\nfor O\nthe O\nFourth B-ORG\nCircuit I-ORG\n, O\nsitting O\nin O\nBaltimore B-LOC\n. O\n\nBut O\n, O\nhe O\nsaid O\n, O\n\" O\nwe O\nstill O\nhave O\nhope O\nthat O\nsomebody O\nis O\ngoing O\nto O\nsee O\nour O\npoint O\nof O\nview O\nin O\nthis O\n. O\n\" O\n\nThe O\nColorado B-LOC\nattorney O\ngeneral O\ntold O\nLloyd B-ORG\n's I-ORG\nlast O\nweek O\nit O\nwas O\nconsidering O\na O\nnew O\nlegal O\naction O\nagainst O\nthe O\nBritish B-MISC\ninsurance O\nmarket O\n, O\nbased O\non O\nallegations O\nof O\nconsumer O\nfraud O\n. O\n\n\" O\nWe O\nhave O\nnotified O\nthem O\nof O\nour O\nconcerns O\nand O\nasked O\nthem O\nto O\ngive O\nus O\na O\nresponse O\n, O\n\" O\nsaid O\nColorado B-LOC\nattorney O\ngeneral O\nGale B-PER\nNorton I-PER\n. O\n\nNorton B-PER\nsaid O\nshe O\nwas O\nconcerned O\nthat O\nthe O\nLloyd B-ORG\n's I-ORG\nagreement O\nimmunizes O\nit O\nfrom O\nfuture O\nlitigation O\nregarding O\nEquitas B-ORG\nand O\nrequires O\nthat O\nall O\nlegal O\nactions O\nbe O\nheard O\noutside O\nof O\nColorado B-LOC\n. O\n\nIn O\naddition O\n, O\nshe O\nsaid O\nshe O\nwas O\nconcerned O\nthe O\nplan O\nmay O\nnot O\noffer O\ninvestors O\nenough O\nprotection O\nfrom O\nadditional O\n, O\nfuture O\nliabilities O\n. O\n\nMeanwhile O\n, O\nan O\nappeal O\nof O\na O\nlawsuit O\nfiled O\nby O\nsome O\n600 O\nNames B-MISC\nin O\nCalifornia B-LOC\nis O\nstill O\npending O\nbefore O\nthe O\nU.S. B-ORG\nCourt I-ORG\nof I-ORG\nAppeals I-ORG\nfor O\nthe O\nNinth B-ORG\nCircuit I-ORG\n, O\nChiate B-PER\nof O\nthe O\nAmerican B-ORG\nNames I-ORG\nAssociation I-ORG\nsaid O\n. O\n\nThat O\nlawsuit O\n, O\nwhich O\nseeks O\nrescision O\nand O\nrestitution O\n, O\nwas O\ndismissed O\nin O\na O\nU.S. B-LOC\ndistrict O\ncourt O\n. O\n\nThat O\ncase O\n\" O\nis O\nwhat O\nI O\ncall O\nthe O\nmost O\nsignificant O\nalternate O\nremedy O\nfor O\nus O\n, O\n\" O\nChiate B-PER\nsaid O\n. O\n\nThe O\nindividual O\nNames B-MISC\n, O\nhowever O\n, O\nnow O\nmust O\ndecide O\nwhether O\nto O\naccept O\nLloyd B-ORG\n's I-ORG\nsettlement O\noffer O\nor O\nreject O\nthe O\noffer O\nand O\npursue O\nlitigation O\n. O\n\nChiate B-PER\nsaid O\nhe O\nhas O\nadvised O\nNames B-MISC\nthat O\n\" O\nthey O\nmust O\nmake O\n, O\nindividually O\n, O\na O\nrisk O\nbenefit O\nanalysis O\n. O\n\" O\n\nRejection O\ninvolved O\nforfeiting O\nthe O\ncompensation O\noffer O\nand O\nrisking O\nthe O\npossibility O\nof O\nowing O\nLloyd B-ORG\n's I-ORG\ntwo O\nto O\nthree O\ntimes O\nmore O\nthan O\nLloyd B-ORG\n's I-ORG\nis O\nnow O\nwilling O\nto O\naccept O\n, O\nhe O\nsaid O\n. O\n\nBut O\n, O\nin O\nrejecting O\nthe O\noffer O\n, O\nthe O\nNames B-MISC\nwould O\nretain O\ntheir O\nrights O\nto O\npursue O\nlitigation O\n, O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nGerman B-MISC\npolice O\nmade O\nNazi B-MISC\ngestures O\n, O\nofficials O\nsay O\n. O\n\nNUREMBERG B-LOC\n, O\nGermany B-LOC\n1996-08-28 O\n\nGerman B-MISC\nriot O\npolice O\nmade O\nNazi B-MISC\ngestures O\nat O\na O\nprivate O\nfunction O\nearlier O\nthis O\nmonth O\nand O\nmay O\nface O\ndismissal O\nfor O\ntheir O\nactions O\n, O\nthe O\nBavarian B-MISC\nInterior B-ORG\nMinistry I-ORG\nsaid O\non O\nWednesday O\n. O\n\nThe O\nministry O\ndeclined O\nto O\ndetail O\ngestures O\nthe O\nNuremberg-based B-MISC\npolicemen O\nhad O\nmade O\nat O\nthe O\nAugust O\n13 O\nfunction O\nbut O\nadded O\nseven O\nhad O\nbeen O\nsuspended O\nfrom O\nduty O\npending O\nan O\ninternal O\ninquiry O\n. O\n\nA O\nspokesman O\nfor O\npublic O\nprosecutors O\nin O\nthe O\nsouthern O\ncity O\n, O\nwhere O\ndictator O\nAdolf B-PER\nHitler I-PER\nheld O\nsome O\nof O\nhis O\nmost O\ninfamous O\nNazi B-MISC\nparty O\nrallies O\nin O\nthe O\n1930s O\n, O\nsaid O\nthere O\nwere O\nno O\nplans O\nto O\nprosecute O\nthe O\nofficers O\nas O\nthe O\ngestures O\nhad O\nnot O\nbeen O\nmade O\nin O\npublic O\n. O\n\n-DOCSTART- O\n\nGun-wielding O\nmotorist O\nsnapped O\nby O\ncool O\npassenger O\n. O\n\nBERLIN B-LOC\n1996-08-28 O\n\nA O\nmotorist O\nthreatened O\na O\nfellow O\ndriver O\nwith O\na O\nstarting O\npistol O\nas O\nhe O\novertook O\nhim O\nillegally O\nin O\nthe O\ninside O\nlane O\non O\na O\nmotorway O\nnear O\nBerlin B-LOC\nand O\nwas O\nphotographed O\nin O\nthe O\nact O\nby O\nthe O\ndriver O\n's O\nwife O\n, O\nprosecutors O\nsaid O\non O\nWednesday O\n. O\n\nProsecutors O\nin O\nthe O\ncity O\nof O\nPotsdam B-LOC\nsaid O\nthe O\n32-year-old O\nman O\ndrew O\nalongside O\nthe O\nother O\ncar O\nat O\nabout O\n110 O\nkph O\n( O\n70 O\nmph O\n) O\nand O\naimed O\nhis O\npistol O\nat O\nthe O\ndriver O\n. O\n\nBut O\nthe O\ndriver O\n's O\nwife O\nkept O\nher O\nnerve O\n, O\ngot O\nout O\nher O\ncamera O\nand O\nphotographed O\nhim O\n. O\n\nThe O\nman O\nhas O\nbeen O\ncharged O\nwith O\ndangerous O\ndriving O\n, O\ncoercion O\nand O\nthreatening O\nbehaviour O\n. O\n\n-DOCSTART- O\n\nGerman B-MISC\nprosecutors O\nfile O\nsex O\ntourism O\ncharges O\n. O\n\nBERLIN B-LOC\n1996-08-28 O\n\nBerlin B-LOC\nprosecutors O\nsaid O\non O\nWednesday O\nthey O\nhad O\nfiled O\ncharges O\nagainst O\ntwo O\nGerman B-MISC\nmen O\nfor O\nsexually O\nabusing O\nchildren O\nin O\nThailand B-LOC\nand O\ndistributing O\npornographic O\nfilms O\nand O\npictures O\nof O\ntheir O\ndegrading O\nacts O\n. O\n\nThe O\ncase O\nis O\none O\nof O\nonly O\na O\nhandful O\nin O\nwhich O\nauthorities O\nhave O\nmanaged O\nto O\ntrack O\ndown O\nsuspects O\nunder O\na O\nlaw O\nwhich O\nlets O\nthem O\npursue O\nGermans B-MISC\nwho O\ncommit O\nsex O\noffences O\nabroad O\n. O\n\nThe O\npair O\n, O\nidentified O\nonly O\nas O\n43-year-old O\nclerk O\nDieter B-PER\nU I-PER\nand O\nbusinessman O\nThomas B-PER\nS I-PER\n, O\n33 O\n, O\nare O\nalleged O\nto O\nhave O\ncarried O\nout O\nacts O\nof O\nsexual O\nindecency O\nwith O\nchildren O\nas O\nyoung O\nas O\n10 O\nyears O\nold O\nbetween O\n1994 O\nand O\n1995 O\n. O\n\nTheir O\nvideos O\nincluded O\npictures O\nof O\none O\nof O\nthe O\naccused O\ntying O\nup O\na O\nThai B-MISC\nboy O\nand O\nperforming O\nacts O\nof O\nsadistic O\ntorture O\non O\nhim O\n, O\nprosecutors O\nsaid O\nin O\na O\nstatement O\n. O\n\nIn O\nanother O\nscene O\n, O\na O\nyoung O\ngirl O\nperformed O\noral O\nsex O\nwith O\nan O\nunidentified O\nadult O\nman O\n. O\n\nThe O\nnew O\nlaw O\nwas O\nintroduced O\nwith O\nmuch O\nfanfare O\nin O\n1993 O\n. O\n\nBut O\nprosecutors O\nface O\nhuge O\ndifficulties O\nin O\ngathering O\nevidence O\nand O\nbringing O\nwitnesses O\nto O\ntestify O\nin O\na O\nGerman B-MISC\ncourt O\n, O\nand O\nonly O\none O\nperson O\nhas O\nso O\nfar O\nbeen O\nconvicted O\nunder O\nthe O\nlaw O\n. O\n\nInvestigators O\nare O\nprobing O\nseveral O\nother O\ncases O\n. O\n\nThe O\nBerlin B-LOC\nprosecutors O\nsaid O\nthey O\nhad O\nbeen O\nalerted O\nto O\nthe O\ntwo O\nmen O\nby O\ncustoms O\nofficials O\nwho O\nintercepted O\npackages O\ncontaining O\npornographic O\nphotographs O\nand O\norder O\nforms O\n. O\n\n-DOCSTART- O\n\nFrance B-LOC\n's O\nJuppe B-PER\non O\nofficial O\nvisit O\nto O\nGreece B-LOC\nSep O\n15 O\n. O\n\nATHENS B-LOC\n1996-08-28 O\n\nFrench B-MISC\nPremier O\nAlain B-PER\nJuppe I-PER\nwill O\npay O\nan O\nofficial O\nvisit O\nto O\nGreece B-LOC\non O\nSeptember O\n15 O\nto O\ncelebrate O\n150 O\nyears O\nof O\nthe O\nFrench B-ORG\nArchaeological I-ORG\nSociety I-ORG\n, O\ngovernment O\nspokesman O\nDimitris B-PER\nReppas I-PER\nsaid O\non O\nWednesday O\n. O\n\nJuppe B-PER\nwill O\nmeet O\nGreek B-MISC\nPrime O\nMinister O\nCostas B-PER\nSimitis I-PER\nand O\nForeign O\nMinister O\nTheodoros B-PER\nPangalos I-PER\n, O\nReppas B-PER\ntold O\nreporters O\n. O\n\n\" O\nThe O\nFrench B-MISC\npremier O\n's O\nvisit O\nwas O\nplanned O\nto O\ncoincide O\nwith O\nthe O\nArchaeological B-ORG\nSociety I-ORG\n's O\ncelebrations O\n. O\n\nThe O\nGreek B-MISC\ngovernment O\nwas O\nasked O\nfor O\nan O\nofficial O\nmeeting O\nwith O\nthe O\nprime O\nminister O\nand O\nthe O\nforeign O\nminister O\nand O\nit O\nsaid O\nyes O\n, O\n\" O\nReppas B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nStork B-ORG\nH1 O\nresults O\nbreakdown O\nper O\nsector O\n. O\n\nAMSTERDAM B-LOC\n1996-08-28 O\n\nFirst O\n24 O\nweeks O\n1996 O\n\n( O\nmillions O\nof O\nguilders O\nunless O\notherwise O\nstated O\n) O\n\nIndustrial O\nsystems O\nand O\ncomponents O\n\n- O\nTurnover O\n756 O\nvs O\n829 O\n\n- O\nOperating O\nprofit O\n46 O\nvs O\n48 O\n\n- O\nNew O\norders O\nreceived O\n876 O\nvs O\n933 O\n\n- O\nOrder O\nbook O\n( O\nbillions O\n) O\n1.07 O\nvs O\n0.98 O\n\nIndustrial O\nservices O\n\n- O\nTurnover O\n657 O\nvs O\n700 O\n\n- O\nOperating O\nprofit O\n9 O\nvs O\n3 O\n\n- O\nNew O\norders O\nreceived O\n( O\nbillions O\n) O\n1.00 O\nvs O\n1.09 O\n\n- O\nOrder O\nbook O\n( O\nbillions O\n) O\n2.37 O\nvs O\n2.01 O\n\nNOTE O\n- O\nOrder O\nbook O\nfigures O\nrefer O\nto O\nvalue O\nof O\norders O\non O\nbooks O\nat O\nend O\nof O\nperiod O\n. O\n\n-- O\nAmsterdam B-LOC\nnewsroom O\n+31 O\n20 O\n504 O\n5000 O\n, O\nFax O\n+31 O\n20 O\n504 O\n5040 O\n\n-DOCSTART- O\n\nStephanie B-PER\nof O\nMonaco B-LOC\n's O\nhusband O\nsnapped O\ncavorting O\n. O\n\nROME B-LOC\n1996-08-28 O\n\nTwo O\nItalian B-MISC\nmagazines O\npublished O\npictures O\non O\nWednesday O\nof O\nDaniel B-PER\nDucruet I-PER\n, O\nPrincess O\nStephanie B-PER\nof O\nMonaco B-LOC\n's O\nhusband O\nand O\nformer O\nbodyguard O\n, O\ncavorting O\nnaked O\nwith O\nanother O\nwoman O\nby O\na O\npoolside O\nin O\nFrance B-LOC\n. O\n\nThe O\nmagazines O\n, O\nEva B-ORG\nTremila I-ORG\nand O\nits O\nsister O\npublication O\nGente B-ORG\n, O\nprinted O\nup O\nto O\n26 O\npages O\nof O\nphotos O\nof O\nthe O\nwoman O\nundressing O\nDucruet B-PER\n, O\nthe O\npair O\nembracing O\non O\na O\nsunbed O\nand O\nfinally O\nboth O\nnaked O\n. O\n\nEva B-ORG\nTremila I-ORG\nsaid O\nother O\neven O\nmore O\nexplicit O\nphotos O\nwere O\ntaken O\nbut O\nit O\ndid O\nnot O\nprint O\nthem O\n. O\n\nThe O\nmagazines O\nnamed O\nthe O\nwoman O\nas O\nFili B-PER\nHouteman I-PER\n, O\na O\n26-year-old O\nFrench B-MISC\nsinger O\nand O\ndancer O\nin O\na O\nBelgian B-MISC\ncabaret O\nclub O\n. O\n\nThe O\nphotographs O\n, O\nan O\nItalian B-MISC\nexclusive O\n, O\nraised O\neyebrows O\nin O\nthe O\ntiny O\nprincipality O\n, O\nwhere O\nStephanie B-PER\n's O\nfather O\nPrince B-PER\nRainier I-PER\n, O\nhad O\nlong O\ndisapproved O\nof O\nhis O\ndaughter O\n's O\nchoice O\nof O\nhusband O\n. O\n\nStephanie B-PER\nhad O\ntwo O\nchildren O\nwith O\nDucruet B-PER\nbefore O\ntheir O\nmarriage O\nin O\nJuly O\nlast O\nyear O\n. O\n\nStephanie B-PER\n, O\nCaroline B-PER\nand O\nAlbert B-PER\nare O\nthe O\nchildren O\nof O\nRainier B-PER\nand O\nformer O\nHollywood B-LOC\nscreen O\ngoddess O\nGrace B-PER\nKelly I-PER\n, O\nwho O\nwas O\nkilled O\nin O\na O\ncar O\ncrash O\nin O\n1982 O\n. O\n\n\" O\nWe O\nhave O\nseen O\nthe O\nphotos O\nbut O\nfor O\nthe O\nmoment O\nthe O\npalace O\nhas O\nno O\ncomment O\n, O\n\" O\na O\nspokeswoman O\nfor O\nPrince B-PER\nRainier I-PER\ntold O\nReuters B-ORG\n. O\n\nThe O\nmagazines O\nsaid O\nthe O\nphotographs O\nwere O\ntaken O\nin O\nCap B-LOC\nde I-LOC\nVillefranche I-LOC\n, O\nsome O\n15 O\nkm O\n( O\nnine O\nmiles O\n) O\nfrom O\nMonte B-LOC\nCarlo I-LOC\n. O\n\nGente B-ORG\nsaid O\nDucruet B-PER\n, O\na O\nkeen O\nracing O\ndriver O\n, O\nmet O\nHouteman B-PER\nduring O\na O\nrace O\nin O\nBelgium B-LOC\nand O\nphotographers O\nhad O\nbeen O\non O\ntheir O\ntrail O\never O\nsince O\n. O\n\nThe O\nmagazine O\nsaid O\nvideo O\ncameras O\nhad O\nalso O\nbeen O\nused O\nto O\nfilm O\nthe O\ncouple O\nand O\nthat O\na O\nsound-track O\nexisted O\n. O\n\n-DOCSTART- O\n\nHighlights O\nof O\nWednesday O\n's O\nCommission B-ORG\nbriefing O\n. O\n\nBRUSSELS B-LOC\n1996-08-28 O\n\nFollowing O\nare O\nhighlights O\nof O\nthe O\nmidday O\nbriefing O\nby O\nthe O\nEuropean B-ORG\nCommission I-ORG\non O\nWednesday O\n: O\n\nIn O\nresponse O\nto O\na O\nquestion O\n, O\nCommission B-ORG\nspokesman O\nJoao B-PER\nVale I-PER\nde I-PER\nAlmeida I-PER\nsaid O\nthere O\nhad O\nbeen O\nno O\ndevelopments O\nregarding O\nthe O\nCommission B-ORG\n's O\nposition O\nconcerning O\nthe O\ndispute O\nwith O\nGermany B-LOC\nand O\nSaxony B-LOC\nover O\nstate O\naid O\nto O\nVolkswagen B-ORG\n. O\n\nHe O\nsaid O\nthere O\nwas O\nsome O\npossibility O\nof O\nfurther O\ntalks O\nwith O\nGermany B-LOC\nbefore O\nthe O\nnext O\nCommission B-ORG\nmeeting O\nof O\nSeptember O\n4 O\n. O\n\n- O\n- O\n- O\n- O\n\nThe O\nCommission B-ORG\nreleased O\nthe O\nfollowing O\ndocuments O\n: O\n\n- O\nIP O\n/ O\n96 O\n/ O\n804 O\n: O\nCommission B-ORG\napproves O\nacquisition O\nof O\nPao B-ORG\nde I-ORG\nAcucar I-ORG\nby O\nAuchan B-ORG\n. O\n\n- O\nIP O\n/ O\n96 O\n/ O\n805 O\n: O\nCommission B-ORG\nfinds O\nacquisition O\nof O\nCAMAT B-ORG\nby O\nAGF-IART B-ORG\ndoes O\nnot O\nfall O\nunder O\nthe O\nmerger O\nregulation O\n. O\n\n- O\nIP O\n/ O\n96 O\n/ O\n806 O\n: O\nCommission B-ORG\nclears O\nacquisition O\nof O\nAustrian B-MISC\nfood O\nretail O\nchain O\nBilla B-ORG\nby O\nGerman B-MISC\ngroup O\nRewe-Handelsgruppe B-ORG\n. O\n\n- O\nSPEECH O\n/ O\n96 O\n/ O\n202 O\n: O\nSpeech O\nby O\nEuropean B-MISC\nCommissioner O\nAnita B-PER\nGradin I-PER\nat O\nthe O\nWorld B-MISC\nCongress I-MISC\nagainst I-MISC\nSexual I-MISC\nExploitation I-MISC\nof I-MISC\nChildren I-MISC\nin O\nStockholm B-LOC\n. O\n\n- O\nEurostat B-ORG\nnews O\nrelease O\n51/96 O\n: O\nMarch-May O\n1996 O\nEU B-ORG\nindustrial O\nproduction O\nfigures O\n. O\n\n-DOCSTART- O\n\nSpanish B-MISC\ntomato O\nwarriors O\npaint O\nthe O\ntown O\nred O\n. O\n\nBUNOL B-LOC\n, O\nSpain B-LOC\n1996-08-28 O\n\nRevellers O\npainted O\nthe O\ntown O\nred O\non O\nWednesday O\nas O\nthe O\n1996 O\nedition O\nof O\nthe O\nworld O\n's O\nbiggest O\ntomato O\nfight O\nbegan O\nin O\nthe O\neastern O\nSpanish B-MISC\nvillage O\nof O\nBunol B-LOC\n. O\n\nThousands O\nof O\npeople O\npelted O\neach O\nother O\nwith O\narmfuls O\nof O\nripe O\ntomatoes O\nas O\nstreets O\n, O\nwalls O\nand O\nwindows O\nwere O\ncoated O\nin O\na O\nblood-red O\nwash O\n. O\n\nA O\nsingle O\nfirework O\nafter O\nmidday O\nsignalled O\nthe O\nstart O\nof O\nthe O\nfruit-throwing O\nfrenzy O\n, O\nduring O\nwhich O\nparticipants O\nhurl O\nsome O\n100 O\ntonnes O\nof O\ntomatoes O\ntrucked O\nin O\nfor O\nthe O\noccasion O\n. O\n\nLocal O\nhistorians O\nsay O\nthe O\ntradition O\nbegan O\nin O\n1945 O\nwhen O\ndisgruntled O\nlocals O\nbegan O\nspontaneously O\nto O\nbombard O\nthe O\npriest O\nand O\nmayor O\nat O\nthe O\nannual O\nfiesta O\nin O\nBunol B-LOC\n( O\npronounced O\nBoo-nee-OL B-LOC\n) O\n. O\n\nThe O\nfestival O\n's O\nfame O\nhas O\ngrown O\nand O\nnow O\nattracts O\nbetween O\n15,000 O\nand O\n20,000 O\npeople O\n, O\nmany O\nof O\nthem O\nforeigners O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nGREECE B-LOC\n- O\nAUG O\n28 O\n. O\n\nATHENS B-LOC\n1996-08-28 O\n\nLeading O\nstories O\nin O\nthe O\nGreek B-MISC\nfinancial O\npress O\n: O\n\nIMERISIA B-ORG\n\n-- O\nPre-election O\ndebate O\nheats O\nup O\non O\neconomic O\nissues O\nas O\nconservative O\nNew B-ORG\nDemocracy I-ORG\nparty O\npromises O\nseven O\nmeasures O\nincludind O\ntax O\nrelief O\nfor O\nfarmers O\nand O\nsocialist O\nPasok B-ORG\ndefends O\nprogress O\non O\neconomic O\nconvergence O\nwith O\nthe O\nEU B-ORG\n\n-- O\nFinance O\nministry O\nscrambles O\nto O\nfind O\ntemporary O\nsolution O\nto O\nregulation O\nwhich O\nslaps O\na O\n15 O\npercent O\ntax O\nrate O\non O\ngains O\nfrom O\ntrading O\nof O\nbonds O\nand O\ncoupons O\nby O\nmutual O\nfunds O\n\n-- O\nFinance O\nministry O\nwill O\ncut O\n12-month O\nT-bill O\nrate O\nby O\n10 O\nbasis O\npoints O\nto O\n12.70 O\npercent O\nin O\nthe O\nupcoming O\nend O\nAugust O\nissue O\n\nFINANCIAL B-ORG\nKATHIMERINI I-ORG\n\n-- O\nInflows O\nof O\nmore O\nthan O\n$ O\n500 O\nmillion O\nare O\nseen O\nin O\nthe O\ninterbank O\nmarket O\nand O\nthe O\nbourse O\nin O\nthe O\nlast O\nthree O\ndays O\nreflecting O\nconfidence O\nin O\nthe O\npost-election O\neconomic O\npolicy O\n\n-- O\nAthens B-ORG\nMetro I-ORG\nsubway O\nproject O\nhits O\nsnags O\nwhich O\ncould O\ndelay O\ndelivery O\nto O\nthe O\nyear O\n2000 O\nand O\novershoot O\nthe O\noriginal O\nbudgeted O\ncost O\nof O\n520 O\nbillion O\ndrachmas O\n\n-- O\nState B-ORG\nNational I-ORG\nBank I-ORG\nof I-ORG\nGreece I-ORG\nwill O\nstart O\nreal O\nauction O\nprogramme O\nSeptember O\n9 O\nto O\nlighten O\nup O\non O\nits O\nreal O\nestate O\nholdings O\n\nKERDOS B-ORG\n\n-- O\nNew B-ORG\nDemocracy I-ORG\nleader O\nMiltiadis B-PER\nEvert I-PER\nvows O\nsupport O\nmesures O\nfor O\nfarmers O\nand O\nsmall O\nbusiness O\nas O\nhe O\nkicks O\noff O\nthe O\nconservative O\nparty O\n's O\ncampaign O\n\n-- O\nNational O\nEconomy O\nMinister O\nYannos B-PER\nPapandoniou I-PER\ndefends O\n\" O\nhard O\ndrachma O\n\" O\nforeign O\nexchange O\npolicy O\n, O\nsays O\nit O\nwo O\nn't O\nchange O\n\nEXPRESS B-ORG\n\n-- O\nMessage O\nof O\nunity O\nfrom O\nthe O\nconservative O\nNew B-ORG\nDemocracy I-ORG\nparty O\nas O\nformer O\nprime O\nminister O\nConstantine B-PER\nMitsotakis I-PER\nand O\nMiltiadis B-PER\nEvert I-PER\nshake O\nhands O\n\nNAFTEMBORIKI O\n\n-- O\nGovernment O\ndefends O\n\" O\nhard O\ndrachma O\n\" O\npolicy O\n, O\nsays O\nit O\nwill O\ncontinue O\nunchanged O\nafter O\nthe O\nelections O\n\n-- O\nConservative O\nopposition O\nNew B-ORG\nDemocracy I-ORG\npromises O\nseries O\nof O\nmeasures O\non O\nthe O\neconomy O\n30 O\ndays O\nafter O\nthe O\nelections O\naiming O\nat O\n4.0 O\npercent O\nGDP O\ngrowth O\nrate O\nannually O\n-- O\nGeorge B-PER\nGeorgiopoulos I-PER\n, O\nAthens B-ORG\nNewsroom I-ORG\n+301 O\n3311812-4 O\n\n-DOCSTART- O\n\nHOEK B-ORG\nLOOS I-ORG\nH1 O\nNET O\nPROFIT O\n28.9 O\nMLN O\nGUILDERS O\n. O\n\nAMSTERDAM B-LOC\n1996-08-28 O\n\nFirst O\nhalf O\n1996 O\n\n( O\nin O\nmillions O\nof O\nguilders O\nunless O\notherwise O\nstated O\n) O\n\nNet O\nper O\nshr O\n( O\nguilders O\n) O\n4.38 O\nvs O\n3.70 O\n\nNet O\nprofit O\n28.9 O\nvs O\n24.5 O\n\nTurnover O\n273.6 O\nvs O\n290.3 O\n\nOperating O\nprofit O\n44.4 O\nvs O\n40.7 O\n\nNote O\n- O\nIndustrial O\ngases O\nmaker O\nHoek B-ORG\nLoos I-ORG\nNV I-ORG\n. O\n\nInterest O\ncharges O\n2.20 O\nvs O\n5.05 O\n\nTax O\n13.26 O\nvs O\n11.16 O\n\n-- O\nAmsterdam B-LOC\nnewsroom O\n+31 O\n20 O\n504 O\n5000 O\n, O\nFax O\n+31 O\n20 O\n504 O\n5040 O\n\n-DOCSTART- O\n\nStagecoach B-ORG\nsees O\nSwebus B-ORG\ndeal O\nagreed O\nnext O\nweek O\n. O\n\nLONDON B-LOC\n1996-08-28 O\n\nBritish B-MISC\nbus O\nand O\npassenger O\nrail O\noperator O\nStagecoach B-ORG\nHoldings I-ORG\nPlc I-ORG\nsaid O\non O\nWednesday O\nthat O\nits O\nnegotiations O\nto O\nacquire O\nSwedish B-MISC\nlong O\ndistance O\nbus O\noperator O\nSwebus B-ORG\nAB I-ORG\nwere O\nset O\nto O\nlead O\nto O\na O\nsigned O\nagreement O\nnext O\nweek O\n. O\n\nFour O\nweeks O\nago O\nStagecoach B-ORG\nsaid O\nit O\nhad O\nagreed O\nthe O\ndeal O\nin O\nprinciple O\n, O\nand O\nit O\nexpected O\nto O\npay O\n110 O\nmillion O\nstg-plus O\nfor O\nthe O\nfirm O\n, O\nwith O\nSwebus B-ORG\n' O\ncurrent O\nowner O\n, O\nthe O\nstate O\nrailway O\ncompany O\n. O\n\n\" O\nThe O\ndirectors O\nreport O\nthat O\nnegotiations O\nwith O\nthe O\nvendors O\nof O\nSwebus B-ORG\nAB I-ORG\nare O\nproceeding O\nand O\nthey O\nexpect O\nan O\nagreement O\n( O\nconditional O\non O\nshareholder O\napproval O\n) O\nwill O\nbe O\nsigned O\nnext O\nweek O\n, O\n\" O\nStagecoach B-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\n-- O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n7717 O\n\n-DOCSTART- O\n\nNZ B-LOC\nbills O\ngain O\nground O\nafter O\nsee-saw O\nsession O\n. O\n\nWELLINGTON B-LOC\n1996-08-28 O\n\n0515 O\nGMT B-MISC\n\nThe O\nNew B-LOC\nZealand I-LOC\nmoney O\nmarket O\ngained O\nslightly O\nat O\nWednesday O\n's O\nclose O\nafter O\nwhat O\ndealers O\ndescribed O\nas O\na O\nsee-saw O\ntrading O\nsession O\n. O\n\nNinety-day O\nbank O\nbill O\nrates O\nshed O\nfive O\npoints O\nto O\n9.93 O\npercent O\nand O\nSeptember O\nbank O\nbill O\nfutures O\nrose O\nfour O\nto O\n90.18 O\n. O\n\nHowever O\n, O\nbonds O\nfinished O\nlargely O\nflat O\n. O\n\n\" O\nOur O\nbonds O\nwere O\nbetter O\nbid O\ninitially O\nbut O\nthey O\nsold O\noff O\non O\na O\nlack O\nof O\ndemand O\n, O\nand O\nthe O\nshort O\nend O\nwent O\nwith O\nit O\ntoo O\non O\na O\nlower O\ncurrency O\n. O\n\n\" O\nThere O\nwere O\nbig O\nbuyers O\nat O\nthe O\nbase O\nof O\nwhere O\nthe O\nmarket O\nsold O\nto O\n, O\nand O\nwhen O\nthe O\ncurrency O\ngot O\nbought O\nback O\non O\ntalk O\nof O\na O\nsamurai O\nthe O\nmarket O\ngot O\nbought O\nback O\nagain O\n, O\n\" O\na O\ndealer O\nsaid O\n. O\n\nVolumes O\nwere O\nreasonable O\nin O\nthe O\nmoney O\nmarket O\nbut O\nthin O\nin O\nbonds O\n. O\n\nDealers O\nsaid O\nthe O\nmarket O\nseemed O\nto O\nbe O\ntrading O\na O\nrange O\nand O\nwould O\nwait O\nfor O\nmore O\npolitical O\npolls O\nto O\nprovide O\ndirection O\n. O\n\nThey O\nwere O\nconfident O\nof O\nfurther O\neurokiwi O\nissuance O\nbut O\nsaid O\nthe O\ntiming O\nwas O\nless O\nof O\na O\ncertainty O\n. O\n\n-- O\nWellington B-LOC\nnewsroom O\n( O\n64 O\n4 O\n) O\n473 O\n4746 O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nGuinness B-ORG\nPeat I-ORG\nexpects O\nstrong O\nfull O\nyr O\n. O\n\nSYDNEY B-LOC\n1996-08-28 O\n\nBritish-based B-MISC\ninvestment O\ncompany O\nGuinness B-ORG\nPeat I-ORG\nGroup I-ORG\nPlc I-ORG\n( O\nGPG B-ORG\n) O\nsaid O\non O\nWednesday O\nit O\nexpected O\na O\nstrong O\nfull O\nyear O\nresult O\n. O\n\n\" O\nWe O\nthink O\nwe O\n're O\nin O\na O\nposition O\nto O\nproduce O\na O\nstrong O\nresult O\n, O\nhowever O\na O\nlot O\nof O\nour O\nprofitability O\nmust O\ninevitably O\ndepend O\non O\na O\nnumber O\nof O\n( O\ncompany O\n) O\nresults O\n, O\n\" O\nsaid O\nGPG B-ORG\ndirector O\nGarry B-PER\nWeiss I-PER\n. O\n\nGPG B-ORG\nearlier O\nsaid O\nits O\nnet O\nprofit O\nfor O\nthe O\nsix O\nmonths O\nto O\nJune O\n30 O\nrose O\nto O\n9.77 O\nmillion O\npounds O\nfrom O\n6.93 O\nmillion O\nin O\nthe O\nprevious O\nfirst O\nhalf O\n. O\n\nThe O\ncompany O\ndid O\nnot O\ndeclare O\nan O\ninterim O\ndividend O\nas O\nin O\nthe O\nprevious O\nyear O\n. O\n\nWeiss B-PER\nsaid O\nthe O\nAustralian B-MISC\nshare O\nmarket O\nhad O\nbeen O\nsomewhat O\nnegative O\nfor O\nmuch O\nof O\n1996 O\nand O\nthis O\nhad O\nsome O\neffect O\non O\nthe O\ncompany O\n's O\nfirst O\nhalf O\nresults O\n. O\n\n\" O\nHowever O\n, O\nit O\ncertainly O\nis O\na O\nvery O\npleasing O\nresult O\nfor O\nthe O\nfirst O\nsix O\nmonths O\n, O\n\" O\nhe O\nsaid O\n. O\n\nWeiss B-PER\nsaid O\nmost O\nof O\nthe O\ncompany O\n's O\nhalf O\nyear O\nearning O\nstemmed O\nfrom O\nthe O\nsale O\nof O\nits O\n50 O\npercent O\nstake O\nin O\nPhysicians B-ORG\nInsurance I-ORG\nCo I-ORG\nof O\nOhio B-LOC\n. O\n\nHe O\nsaid O\nthe O\ncompany O\ndecided O\nto O\nsell O\nits O\nU.S. B-LOC\ninvestment O\nin O\norder O\nto O\nconsolidate O\ninvestments O\ncloser O\nto O\nits O\nadministrative O\nbase O\n. O\n\nGPG B-ORG\nsaid O\nits O\nstakes O\nin O\nTyndall B-ORG\nAustralia I-ORG\nLtd I-ORG\nand O\nMid-East B-ORG\nMinerals I-ORG\nLtd I-ORG\nboth O\ncontributed O\nstrongly O\nto O\nGPG B-ORG\n's O\nfirst O\nhalf O\nearnings O\n. O\n\n-- O\nSydney B-ORG\nNewsroom I-ORG\n61-2 O\n9373-1800 O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nNewcrest B-ORG\nQ4 I-ORG\nnet O\nprofit O\nA$ B-MISC\n4.3 O\nmln O\n. O\n\nSYDNEY B-LOC\n1996-08-28 O\n\nGold O\nminer O\nNewcrest B-ORG\nMining I-ORG\nLtd I-ORG\nsaid O\non O\nWednesday O\nit O\nposted O\na O\nA$ B-MISC\n4.3 O\nmillion O\nprofit O\nafter O\ntax O\nin O\nthe O\nfinal O\nquarter O\nof O\nthe O\nyear O\nto O\nJune O\n30 O\n, O\n1996 O\n. O\n\nEarlier O\n, O\nNewcrest B-ORG\nreported O\na O\ndrop O\nin O\nnet O\nprofit O\nafter O\nabnormals O\nto O\nA$ B-MISC\n20.81 O\nmillion O\nfor O\nthe O\nyear O\nfrom O\nA$ B-MISC\n42.4 O\nmillion O\nthe O\nprevious O\nyear O\n. O\n\nNewcrest B-ORG\nsaid O\nearnings O\nfrom O\nthe O\nTelfer B-LOC\nand O\nBoddington B-LOC\nmines O\nwere O\nlower O\nthan O\nthe O\nprevious O\nyear O\ndue O\nto O\nlower O\nhead O\ngrades O\nat O\nthe O\nmines O\n, O\nforcing O\ngold O\nproduction O\nlower O\n. O\n\nProduction O\ncosts O\nalso O\nrose O\neight O\npercent O\nduring O\nthe O\nyear O\nto O\nA$ B-MISC\n406 O\nper O\nounce O\n. O\n\n-DOCSTART- O\n\nRTRS B-ORG\n- O\nQueensland B-LOC\ngunman O\nevades O\npolice O\nin O\nbush O\nhunt O\n. O\n\nBRISBANE B-ORG\n1996-08-28 O\n\nAustralian B-MISC\npolice O\non O\nWednesday O\ncontinued O\nto O\nhunt O\na O\ngunman O\nin O\ndense O\nbushland O\nafter O\nhe O\nkilled O\nhis O\nwife O\nand O\nwounded O\nthree O\nother O\npeople O\n, O\nwarning O\nthe O\nman O\nis O\nextremely O\ndangerous O\nand O\nmay O\ntake O\na O\nhostage O\nto O\nescape O\n. O\n\nThe O\nshooting O\noccured O\naround O\n6.30 O\na.m. O\n( O\n2030 O\nGMT B-MISC\n) O\non O\nTuesday O\nat O\nGlenwood B-LOC\n, O\nsouth O\nof O\nMaryborough B-PER\n, O\nabout O\n150 O\nkm O\n( O\n93 O\nmiles O\n) O\nnorth O\nof O\nBrisbane B-LOC\non O\nthe O\nQueensland B-LOC\nstate O\ncoast O\n. O\n\nPolice O\nhave O\ndeclared O\nan O\n\" O\nemergent O\nsituation O\n\" O\nin O\nthe O\narea O\n, O\ngiving O\nthem O\npowers O\nto O\nraid O\nhouses O\n, O\nsearch O\ncars O\n, O\nclose O\nschools O\n, O\nquarantine O\nthe O\narea O\nand O\nevacuate O\npeople O\n. O\n\n\" O\nIt O\nis O\none O\nstep O\nshort O\nof O\nan O\nemergency O\nsituation O\n, O\n\" O\na O\npolice O\nspokesman O\nsaid O\nvia O\ntelephone O\nfrom O\na O\ncommand O\npost O\nin O\nthe O\nbush O\n. O\n\n\" O\nWe O\nhave O\nnot O\nhad O\nany O\nsightings O\n, O\nbut O\nwe O\nsuspect O\nhe O\nis O\narmed O\n, O\npossibly O\nwith O\na O\n.22 O\nrifle O\nand O\n/ O\nor O\na O\nself-loading O\nshotgun O\n. O\n\nHe O\nis O\nconsidered O\nextremely O\ndangerous O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nIt O\n's O\na O\npossibility O\n, O\nnot O\na O\nprobability O\n, O\nhe O\nmay O\ntake O\na O\nhostage O\n, O\nbut O\nwe O\nhave O\nmeasures O\nin O\nplace O\nif O\nthat O\nis O\nthe O\ncase O\n. O\n\" O\n\nWilliam B-PER\nFox I-PER\nbroke O\ninto O\nhis O\nwife O\n's O\nhome O\non O\nTuesday O\nmorning O\n, O\nshooting O\nher O\ndead O\nand O\nwounding O\nhis O\n16-year-old O\nson O\n, O\nhis O\nson O\n's O\ngirlfriend O\nand O\na O\nneighbour O\n, O\npolice O\nsaid O\n. O\n\nAll O\nthree O\nwounded O\nare O\nin O\na O\nsatisfactory O\ncondition O\nin O\nhospital O\n. O\n\nFox B-PER\ninitially O\nfled O\nfrom O\nthe O\nshooting O\nin O\na O\ncar O\n, O\nbut O\nthen O\nabandoned O\nthe O\ncar O\nand O\nentered O\ndense O\nbushland O\n. O\n\nFox B-PER\nis O\na O\nskilled O\nbushman O\nwho O\nknows O\nthe O\narea O\nvery O\nwell O\n, O\npolice O\nsaid O\n. O\n\nAbout O\n60 O\npolice O\n, O\nhelicopters O\nand O\nfixed-wing O\naircraft O\nhave O\nmaintained O\nan O\novernight O\ncordon O\naround O\n15 O\nsq O\nkm O\n( O\nsix O\nsq O\nmiles O\n) O\nof O\nbush O\nnear O\nGlenwood B-LOC\n. O\n\nThe O\narea O\nis O\nlittered O\nwith O\ncaves O\nand O\npolice O\nbelieved O\nFox B-PER\nhas O\na O\nhideout O\nwhich O\nhas O\nenabled O\nhim O\nto O\nevade O\ncapture O\n. O\n\nAustralia B-LOC\n's O\nsix O\nstates O\nand O\ntwo O\nterritories O\nare O\ninvolved O\nin O\nheated O\ndebate O\nover O\nthe O\nintroduction O\nof O\ntough O\nnew O\nfirearm O\nlaws O\n, O\nincluding O\nthe O\nbanning O\nrapid O\nfire O\nweapons O\n, O\nafter O\na O\nshooting O\nmassacre O\nin O\nthe O\nisland O\nstate O\nof O\nTasmania B-LOC\n. O\n\nOn O\nApril O\n28 O\n, O\na O\nlone O\ngunman O\nwent O\non O\na O\nshooting O\nrampage O\nat O\nthe O\nsite O\nof O\nthe O\nhistoric O\nPort B-LOC\nArthur I-LOC\npenal O\nsettlement O\n, O\nkilling O\n35 O\npeople O\n. O\n\n-DOCSTART- O\n\nShanghai B-ORG\nEk I-ORG\nChor I-ORG\nopens O\nnew O\nmotorcyle O\nplant O\n. O\n\nSHANGHAI B-LOC\n1996-08-28 O\n\nShanghai-Ek B-ORG\nChor I-ORG\nMotorcycle I-ORG\nCo I-ORG\n, O\na O\nSino-Thai B-ORG\njoint O\nventure O\n, O\nopened O\na O\nnew O\nplant O\nto O\nproduce O\ngasoline O\nengines O\nin O\nthe O\nPudong B-LOC\nNew I-LOC\nArea I-LOC\nof O\nShanghai B-LOC\n, O\nthe O\nXinhua B-ORG\nnews O\nagency O\nreported O\non O\nWednesday O\n. O\n\nThe O\nplant O\n, O\nrequiring O\nan O\ninvestment O\nof O\nthree O\nbillion O\nbaht O\n, O\nhas O\na O\nfloor O\nspace O\nof O\n50,000 O\nsquare O\nmetres O\nand O\nis O\ndesigned O\nto O\nproduce O\n600,000 O\ngasoline O\nengines O\na O\nyear O\n, O\nto O\nbe O\nsold O\nin O\nChina B-LOC\n, O\nSouth B-LOC\nAmerica I-LOC\n, O\nthe O\nMiddle B-LOC\nEast I-LOC\nand O\nAfrica B-LOC\n, O\nit O\nsaid O\n. O\n\nCapacity O\nis O\nexpected O\nto O\nreach O\none O\nmillion O\nengines O\nby O\nthe O\nyear O\n2000 O\n, O\nit O\nsaid O\n. O\n\nShanghai-Ek B-ORG\nChor I-ORG\nis O\njointly O\nowned O\nby O\nthe O\nShanghai B-ORG\nAutomobile I-ORG\nCorporation I-ORG\nand O\nEk B-ORG\nChor I-ORG\nChina I-ORG\nMotorcycle I-ORG\n. O\n\nIt O\nstarted O\noperations O\nin O\nJanuary O\n1985 O\nand O\nhas O\nregistered O\ncapital O\nof O\n1.56 O\nbillion O\nbaht O\n, O\nit O\nsaid O\nbut O\ngave O\nno O\nfurther O\ndetails O\n. O\n\nThe O\njoint O\nventure O\nhas O\ntwo O\nmotorcycle O\nplants O\nmaking O\nXingfu B-MISC\nmotorcycles O\nand O\naims O\nto O\nbe O\nChina B-LOC\n's O\nbiggest O\nproducer O\nby O\nthe O\nyear O\n2000 O\n, O\nwith O\noutput O\nof O\ntwo O\nmillion O\nunits O\n. O\n\n-DOCSTART- O\n\nKhmer B-ORG\nRouge I-ORG\n's O\nIeng B-PER\nSary I-PER\nconfirms O\nbreak O\nwith O\nPol B-PER\nPot I-PER\n. O\n\nARANYAPRATHET O\n, O\nThailand B-LOC\n1996-08-28 O\n\nDissident O\nKhmer B-ORG\nRouge I-ORG\nleader O\nIeng B-PER\nSary I-PER\nconfirmed O\non O\nWednesday O\nthat O\nhe O\nhad O\nbroken O\nwith O\nPol B-PER\nPot I-PER\nand O\nother O\nhardliners O\nof O\nthe O\nguerrilla O\ngroup O\nand O\nhad O\nformed O\na O\nrival O\nmovement O\n. O\n\nIeng B-PER\nSary I-PER\nsaid O\nin O\na O\nwritten O\nstatement O\n, O\nthe O\nfirst O\nsince O\nhis O\nsplit O\nwith O\nPol B-PER\nPot I-PER\nearlier O\nthis O\nmonth O\n, O\nthat O\nthe O\nnew O\nmovement O\nto O\nbe O\ncalled O\nthe O\nDemocratic B-ORG\nNational I-ORG\nUnited I-ORG\nMovement I-ORG\n( O\nDNUM B-ORG\n) O\nwould O\nseek O\nan O\nend O\nto O\ncivil O\nwar O\nand O\nwork O\ntowards O\nreconciliation O\nwith O\nthe O\nCambodian B-MISC\ngovernment O\n. O\n\n\" O\nI O\nwould O\nlike O\nto O\ninform O\nyou O\nabout O\nmy O\ndecision O\nto O\nbreak O\naway O\nfrom O\nPol B-PER\nPot I-PER\n, O\nTa B-PER\nMok I-PER\n, O\nSon B-LOC\nSen I-LOC\n's O\ndictatorial O\ngroup O\n, O\n\" O\nhe O\nsaid O\nin O\na O\ncopy O\nof O\nthe O\nstatement O\nobtained O\nby O\nReuters B-ORG\n. O\n\n\" O\nWe O\nbelieve O\nthat O\nour O\ncountry O\nwill O\nbe O\nreduced O\nto O\nnothing O\nif O\nthe O\nKhmer B-ORG\npeople O\ncontinue O\nto O\nfight O\nagainst O\neach O\nother O\nindefinitely O\n.... O\n\nFor O\nthis O\nreason O\nwe O\ndecided O\nto O\nbreak O\naway O\nfrom O\nthat O\ndictatorial O\ngroup O\nand O\nfound O\na O\nmovement O\nnamed O\n' O\nDemocratic B-ORG\nNational I-ORG\nUnited I-ORG\nMovement I-ORG\n' O\n, O\n\" O\nhe O\nsaid O\n. O\n\nIeng B-PER\nSary I-PER\nwas O\nsentenced O\nto O\ndeath O\nin O\nabsentia O\nfor O\nhis O\nrole O\nin O\nthe O\nmass O\ngenocide O\nin O\nCambodia B-LOC\nduring O\nthe O\nKhmer B-ORG\nRouge I-ORG\nrule O\nof O\nterror O\nbetween O\n1975-1979 O\nwhen O\nover O\na O\nmillion O\npeople O\nwere O\nexecuted O\nor O\ndied O\nof O\nstarvation O\n, O\ndisease O\nor O\noverwork O\nin O\nmass O\nlabour O\ncamps O\n. O\n\nThe O\nFrench-educated B-MISC\n, O\nformer O\nbrother-in-law O\nof O\nPol B-PER\nPot I-PER\nwas O\nforeign O\nminister O\nin O\nthe O\nKhmer B-ORG\nRouge I-ORG\ngovernment O\nthat O\nruled O\nCambodia B-LOC\nand O\nwas O\nseen O\nas O\nthe O\ngroup O\n's O\nsecond O\nin O\ncommand O\n. O\n\n-DOCSTART- O\n\nTwo O\ndead O\nin O\nCambodia B-LOC\nhelicopter O\ncrash O\n. O\n\nPHNOM B-LOC\nPENH I-LOC\n1996-08-28 O\n\nTwo O\npeople O\nwere O\nkilled O\nand O\nsix O\nwere O\ninjured O\nafter O\na O\nhelicopter O\ncrashed O\nin O\nbad O\nweather O\nin O\nnorthern O\nCambodia B-LOC\n, O\na O\ngovernment O\nminister O\nsaid O\non O\nWednesday O\n. O\n\nThe O\n15 O\nsurvivors O\nwho O\nhad O\nbeen O\non O\nboard O\nthe O\nRussian-made B-MISC\nMI-17 B-MISC\nhelicopter O\nwere O\ntaken O\nto O\nhospital O\nfrom O\nthe O\nremote O\njungle O\ncrash O\nsite O\nabout O\n150 O\nkm O\n( O\n90 O\nmiles O\n) O\nnorth O\nof O\nPhnom B-LOC\nPenh I-LOC\n, O\nInformation O\nMinister O\nIeng B-PER\nMouly I-PER\nsaid O\n. O\n\nThe O\ncause O\nof O\nthe O\ncrash O\nof O\nthe O\nhelicopter O\n, O\nwhich O\nwent O\ndown O\non O\nSunday O\nwhile O\non O\na O\nroutine O\nresupply O\nflight O\nbetween O\nPhnom B-LOC\nPenh I-LOC\nand O\nStung B-LOC\nTreng I-LOC\n, O\nwas O\nnot O\nknown O\n. O\n\nIeng B-PER\nMouly I-PER\nsaid O\nthe O\naircraft O\nwent O\ndown O\nduring O\na O\nrain O\nstorm O\n. O\n\n-DOCSTART- O\n\nMOF B-ORG\n's O\nKubo B-PER\nsays O\nbelieves O\nBOJ B-ORG\nrate O\npolicy O\nunchanged O\n. O\n\nTOKYO B-LOC\n1996-08-28 O\n\nJapan B-LOC\n's O\nFinance O\nMinister O\nWataru B-PER\nKubo I-PER\ntold O\na O\nnews O\nconference O\non O\nWednesday O\nthat O\nhe O\nbelieves O\nthat O\nthe O\nBank B-ORG\nof I-ORG\nJapan I-ORG\n's O\n( O\nBOJ B-ORG\n) O\ninterest O\nrate O\npolicy O\nwhich O\nis O\ngeared O\ntowards O\nensuring O\neconomic O\ngrowth O\nhas O\nnot O\nchanged O\nafter O\nthe O\nrelease O\nof O\nthe O\ncentral O\nbank O\n's O\n\" O\ntankan O\n\" O\nsurvey O\n. O\n\nThe O\nBOJ B-ORG\nreleased O\nthe O\nAugust O\ntankan O\n, O\nits O\nquarterly O\nshort-term O\ncorporate O\nsurvey O\n, O\nin O\nthe O\nmorning O\nand O\nit O\nshowed O\nbusiness O\noutlook O\nhad O\nworsened O\n. O\n\nHowever O\n, O\nKubo B-PER\nsaid O\nit O\ndid O\nnot O\nnecessarily O\nshow O\na O\nsubstantial O\nworsening O\nof O\nthe O\neconomy O\n. O\n\n\" O\nThe O\nquestion O\nis O\nwhat O\nthe O\nBOJ B-ORG\nis O\ngoing O\nto O\ndo O\nwith O\nits O\ninterest O\nrate O\npolicy O\n. O\n\nThe O\nBOJ B-ORG\ngovernor O\nhas O\nmade O\nit O\nclear O\nthat O\nthe O\nBOJ B-ORG\n's O\npolicy O\nis O\naimed O\nat O\nensuring O\nbasis O\nfor O\neconomic O\nrecovery O\n. O\n\nI O\nbelieve O\nthis O\npolicy O\nhas O\nnot O\nchanged O\n, O\n\" O\nhe O\nsaid O\n. O\n\nAsked O\nif O\na O\nsupplementary O\nbudget O\nfor O\n1996/97 O\nwas O\nneeded O\nto O\nsupport O\nthe O\neconomy O\n, O\nKubo B-PER\nsaid O\nthe O\ntankan O\nresults O\nwould O\nnot O\nlead O\nto O\nany O\nimmediate O\ndecision O\non O\nthe O\nneed O\nfor O\nan O\nextra O\nbudget O\n. O\n\n\" O\nI O\ndo O\nn't O\nthink O\nwe O\nshould O\nimmediately O\ndraw O\na O\nconclusion O\nthat O\nthe O\neconomic O\nrecovery O\nhas O\ncome O\nto O\na O\nhalt O\nor O\nthat O\nsigns O\nof O\na O\neconomic O\ncontraction O\nhave O\nemerged O\n, O\n\" O\nKubo B-PER\nsaid O\n. O\n\" O\n\nThe O\neconomy O\nis O\nnot O\nrecovering O\nsmoothly O\nor O\nat O\na O\nfast O\npace O\n. O\n\" O\n\nKubo B-PER\nsaid O\nhe O\nwould O\nmake O\na O\ndecision O\non O\nthe O\nneed O\nfor O\na O\nsupplementary O\nbudget O\nafter O\nan O\nannouncement O\nin O\nmid-September O\nof O\nJapan B-LOC\n's O\ngross O\ndomestic O\nproduct O\nfor O\nthe O\nApril-June O\nquarter O\n. O\n\n\" O\nI O\nwould O\nlike O\nto O\nsee O\nhow O\nthe O\neconomy O\nmoved O\nin O\nthe O\nfirst O\nhalf O\nof O\n1996 O\n, O\n\" O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nChina B-LOC\nsays O\nmilitant O\nJapan B-LOC\nmust O\nface O\nwar O\npast O\n. O\n\nBEIJING B-LOC\n1996-08-28 O\n\nChina B-LOC\non O\nWednesday O\ncalled O\non O\nJapan B-LOC\nto O\nacknowledge O\nits O\nwartime O\npast O\nand O\nput O\na O\nstop O\nto O\na O\ntide O\nof O\nresurgent O\nmilitarism O\nto O\nprevent O\nsimilar O\natrocities O\nin O\nfuture O\n. O\n\n\" O\nSome O\nJapanese B-MISC\nare O\nstill O\nunrepentant O\nabout O\nthe O\natrocities O\ncommitted O\nby O\nthe O\nJapanese B-MISC\nmilitarists O\nduring O\nthe O\nwar O\n, O\n\" O\nsaid O\na O\ncommentary O\nin O\nthe O\nofficial O\nChina B-ORG\nDaily I-ORG\n. O\n\n\" O\nIf O\nthey O\nare O\nstill O\nundecided O\nwhether O\nthe O\nwar O\nJapan B-LOC\nlaunched O\nwas O\naggressive O\nin O\nnature O\n, O\nit O\nwill O\nbe O\ndifficult O\nto O\ntell O\nwhether O\nthey O\nwill O\ndo O\nthe O\nsame O\nagain O\n, O\n\" O\nthe O\nnewspaper O\nsaid O\n. O\n\nChina B-LOC\nraised O\nindignant O\nprotests O\nafter O\nseveral O\nJapanese B-MISC\ncabinet O\nministers O\nvisited O\na O\nshrine O\ndedicated O\nto O\ntheir O\ncountry O\n's O\nwar O\ndead O\non O\nAugust O\n15 O\n, O\nthe O\n51st O\nanniversary O\nof O\nJapan B-LOC\n's O\nWorld B-MISC\nWar I-MISC\nTwo I-MISC\nsurrender O\n. O\n\n\" O\nNumerous O\nJapanese B-MISC\npoliticians O\nhave O\ntried O\nto O\nwhitewash O\ntheir O\ncountry O\n's O\nwar O\natrocities O\nin O\nrecent O\nyears O\n, O\n\" O\nthe O\ncommentary O\nsaid O\n. O\n\nChina B-LOC\nestimates O\n35 O\nmillion O\nChinese B-MISC\nwere O\nkilled O\nor O\nwounded O\nby O\ninvading O\nJapanese B-MISC\ntroops O\nfrom O\n1931 O\nto O\n1945 O\n. O\n\n\" O\nThe O\nJapanese B-MISC\nhave O\nnever O\ngenuinely O\napologised O\nfor O\ntheir O\nwartime O\ncrimes O\n, O\n\" O\nthe O\ncommentary O\nsaid O\n. O\n\nJapanese B-MISC\nPrime O\nMinister O\nRyutaro B-PER\nHashimoto I-PER\nmarked O\nthe O\nAugust O\n15 O\nanniversary O\nby O\nexpressing O\n\" O\nremorse O\n\" O\nfor O\nforeign O\nvictims O\nof O\nJapan B-LOC\n's O\nWorld B-MISC\nWar I-MISC\nTwo I-MISC\natrocities O\n. O\n\n-DOCSTART- O\n\nJapan B-LOC\ncoalition O\nparty O\nleader O\nplans O\nto O\nresign O\n. O\n\nTOKYO B-LOC\n1996-08-28 O\n\nThe O\nleader O\nof O\na O\njunior O\npartner O\nin O\nJapan B-LOC\n's O\nthree-party O\nruling O\ncoalition O\nplans O\nto O\nresign O\nto O\nquell O\na O\npolitical O\nrebellion O\n, O\nparty O\nofficials O\nsaid O\non O\nWednesday O\n. O\n\nThe O\nofficials O\nsaid O\nNew B-ORG\nParty I-ORG\nSakigake I-ORG\nPresident O\nMasayoshi B-PER\nTakemura I-PER\n, O\nfinance O\nminister O\nuntil O\nthe O\nbeginning O\nof O\nthis O\nyear O\n, O\npromised O\nhis O\nresignation O\nin O\na O\nmeeting O\nwith O\nthe O\npolitician O\nwho O\nset O\noff O\nthe O\nrebellion O\nin O\nthe O\nsmallest O\ncoalition O\nmember O\n. O\n\nThey O\nsaid O\nthe O\ndate O\nof O\nTakemura B-PER\n's O\nresignation O\nwould O\nbe O\ndetermined O\nby O\nparty O\nofficials O\n. O\n\nThe O\nSakigake B-ORG\nrow O\nhas O\ncaused O\njitters O\nin O\nits O\ncoalition O\npartners O\n, O\nPrime O\nMinister O\nRyutaro B-PER\nHashimoto I-PER\n's O\nLiberal B-ORG\nDemocratic I-ORG\nParty I-ORG\n( O\nLDP B-ORG\n) O\n, O\nthe O\nbiggest O\ngrouping O\n, O\nand O\nthe O\nSocial B-ORG\nDemocratic I-ORG\nParty I-ORG\n. O\n\nBut O\nanalysts O\nsaid O\nthe O\nrow O\nwas O\nnot O\nexpected O\nto O\nimmediately O\ndestabilise O\nthe O\ngovernment O\nas O\neven O\nif O\nSakigake B-ORG\nsplits O\napart O\nit O\nhas O\nso O\nfew O\nseats O\na O\nloss O\nof O\nsupport O\nwould O\nnot O\nlead O\nto O\na O\ngeneral O\nelection O\n. O\n\nThe O\ndispute O\npits O\nTakemura B-PER\n, O\nwho O\nfounded O\nSakigake B-ORG\nin O\n1993 O\nas O\na O\nreform-oriented O\nLDP B-ORG\nsplinter O\ngroup O\n, O\nagainst O\nparty O\nofficial O\nYukio B-PER\nHatoyama I-PER\n, O\nwho O\nsays O\nhe O\nwill O\nleave O\nSakigake B-ORG\nto O\nform O\na O\nreformist O\npolitical O\ngroup O\nnext O\nmonth O\n. O\n\nHatoyama B-PER\n, O\nthe O\n49-year-old O\ngrandson O\nof O\na O\n1950s O\nprime O\nminister O\n, O\non O\nTuesday O\nquit O\nas O\nSakigake B-ORG\nsecretary O\ngeneral O\nand O\nhas O\npublicly O\nsnubbed O\nthe O\n62-year-old O\nTakemura B-PER\n, O\npointedly O\nruling O\nhis O\nmentor O\nout O\nas O\na O\npossible O\nmember O\nof O\nthe O\nnew O\npolitical O\nforce O\n. O\n\nMarathon O\ntalks O\nbetween O\nthe O\ntwo O\nformer O\nallies O\non O\nTuesday O\nnight O\nand O\nWednesday O\nmorning O\nfailed O\nto O\nresolve O\nthe O\ndispute O\nover O\nthe O\nrole O\nof O\nTakemura B-PER\n, O\nseen O\nby O\nHatoyama B-PER\nbackers O\nas O\ntainted O\nby O\nhis O\nsenior O\nrole O\nin O\nthe O\nLDP-dominated B-MISC\ncoalition O\n. O\n\nThe O\npresence O\nof O\nTakemura B-PER\n, O\nwhose O\nrole O\nas O\nfinance O\nminister O\nin O\npassing O\nan O\nunpopular O\nplan O\nto O\nuse O\ntaxpayer O\nfunds O\nto O\nwind O\nup O\nfailed O\nhousing O\nloan O\nfirms O\nruined O\nhis O\nreputation O\nas O\na O\nreformer O\n, O\nhas O\nstalled O\nHatoyama B-PER\n's O\nefforts O\nto O\nattract O\nto O\nhis O\nnew O\ngroup O\ndefectors O\nfrom O\nthe O\nopposition O\ncamp O\n, O\nanalysts O\nsaid O\n. O\n\nMedia O\nreports O\nsay O\nthat O\nat O\nmost O\n10 O\nof O\n23 O\nSakigake B-ORG\nmembers O\n, O\njoined O\nby O\na O\nhandful O\nof O\nSocial B-MISC\nDemocrats I-MISC\n, O\nwill O\nfollow O\nHatoyama B-PER\nwhen O\nhe O\nbolts O\n-- O\nfar O\nshort O\nof O\nthe O\n50 O\nlawmakers O\nneeded O\nto O\ntopple O\nHashimoto B-PER\n's O\neight-month-old O\ngovernment O\n. O\n\nHashimoto B-PER\n-- O\nwho O\nreturns O\nfrom O\na O\n10-day O\nLatin B-MISC\nAmerican I-MISC\ntour O\non O\nSaturday O\n-- O\nmust O\ncall O\npolls O\nby O\nmid-1997 O\n, O\nand O\nhas O\nrepeatedly O\nsaid O\nhe O\nwould O\nnot O\ncall O\nan O\nearly O\ngeneral O\nelection O\n. O\n\nBut O\nmany O\nanalysts O\nand O\npoliticians O\nbelieve O\nhe O\nmay O\ndissolve O\nparliament O\nsoon O\nafter O\nit O\nreconvenes O\nin O\nearly O\nOctober O\n. O\n\n-DOCSTART- O\n\nLiu B-ORG\nChong I-ORG\nHing I-ORG\ninterim O\nnet O\nup O\n2.7 O\npct O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-28 O\n\nSix O\nmonths O\nended O\nJune O\n30 O\n\n( O\nin O\nmillion O\nHK$ B-MISC\nunless O\nstated O\n) O\n\nShr O\n( O\nH.K. B-LOC\ncents O\n) O\n65.61 O\nvs O\n63.87 O\n\nDividend O\n( O\nH.K. B-LOC\ncents O\n) O\n18.0 O\nvs O\n18.0 O\n\nExceptional O\nitems O\nnil O\nvs O\nnil O\n\nNet O\n249.53 O\nvs O\n242.94 O\n\nTurnover O\n119.49 O\nvs O\n134.40 O\n\nCompany O\nname O\nLiu B-ORG\nChong I-ORG\nHing I-ORG\nInvestment I-ORG\nLtd I-ORG\n\nBooks O\nclose O\nSeptember O\n23-27 O\n\nDividend O\npayable O\nOctober O\n8 O\n\nNOTE O\n- O\nLiu B-ORG\nChong I-ORG\nHing I-ORG\nengages O\nin O\nproperty O\ndevelopment O\nand O\ninvestment O\n, O\nwarehousing O\n, O\nbanking O\nand O\ninsurance O\nservices O\n. O\n\n-- O\nHong B-ORG\nKong I-ORG\nNewsroom I-ORG\n( O\n852 O\n) O\n2843 O\n6368 O\n\n-DOCSTART- O\n\nFire O\nbomb O\nhurled O\nat O\nU.S. B-LOC\nconsulate O\nin O\nIndonesia B-LOC\n. O\n\nJAKARTA B-LOC\n1996-08-28 O\n\nA O\nfire O\nbomb O\nwas O\nthrown O\nover O\nthe O\nfence O\ninto O\nthe O\ngrounds O\nof O\nthe O\nU.S. B-LOC\nConsulate-General O\nin O\nIndonesia B-LOC\n's O\nsecond O\nlargest O\ncity O\nof O\nSurabaya B-LOC\nbut O\nno O\none O\nwas O\nhurt O\n, O\na O\nmission O\nofficial O\nsaid O\non O\nWednesday O\n. O\n\nCraig B-PER\nStromme I-PER\n, O\nU.S. B-LOC\nembassy O\nspokesman O\nin O\nJakarta B-LOC\n, O\n700 O\nkm O\n( O\n430 O\nmiles O\n) O\nwest O\nof O\nSurabaya B-LOC\n, O\nconfirmed O\nthe O\nTuesday O\nmorning O\nattack O\n. O\n\n\" O\nSomebody O\nthrew O\na O\nmolotov O\ncocktail O\nover O\nthe O\nfence O\nand O\nit O\nwent O\ninto O\nthe O\nparking O\nlot O\n. O\n\nIt O\ndid O\nn't O\nhit O\nanybody O\nor O\nanything O\n, O\n\" O\nStromme B-PER\nsaid O\n. O\n\nHe O\nsaid O\nthere O\nwas O\nno O\nimmediate O\nexplanation O\nfor O\nthe O\nattack O\nor O\nany O\ninformation O\non O\nthose O\nresponsible O\n. O\n\n-DOCSTART- O\n\nShanghai B-LOC\nnovelist O\nmurdered O\nat O\nhome O\n. O\n\nSHANGHAI B-LOC\n1996-08-28 O\n\nA O\nShanghai B-LOC\nnovelist O\nwas O\nmurdered O\nat O\nher O\nhome O\non O\nSunday O\n, O\nan O\nofficial O\nof O\nthe O\ncity O\n's O\nWriters B-ORG\nAssociation I-ORG\nsaid O\non O\nWednesday O\n. O\n\nThe O\nvictim O\nwas O\nDai B-PER\nHouying I-PER\n, O\nwho O\nwrote O\nabout O\nChina B-LOC\n's O\n1966-76 O\nleftist O\nCultural B-MISC\nRevolution I-MISC\nand O\nthe O\nlives O\nof O\nChinese B-MISC\nintellectuals O\n, O\nthe O\nofficial O\nsaid O\n. O\n\nThe O\nkilling O\nwas O\nunder O\ninvestigation O\n, O\nshe O\nsaid O\n. O\n\nShe O\ngave O\nno O\nfurther O\ndetails O\n. O\n\nBorn B-LOC\nin O\n1937 O\nin O\nthe O\ncentral O\nprovince O\nof O\nAnhui B-LOC\n, O\nDai B-PER\ncame O\nto O\nShanghai B-LOC\nas O\na O\nstudent O\nand O\nremained O\nin O\nthe O\ncity O\nas O\na O\nprolific O\nauthor O\nand O\nteacher O\nof O\nChinese B-MISC\n. O\n\nShe O\nwas O\ndivorced O\nand O\nlived O\nalone O\n, O\nleaving O\none O\ndaughter O\nwho O\nreceived O\nuniversity O\neducation O\nin O\nHawaii B-LOC\nand O\nlives O\nin O\nChicago B-LOC\n, O\na O\nfriend O\nsaid O\n. O\n\nDai B-PER\n's O\nmost O\nfamous O\nbook O\n, O\n\" O\nRen B-MISC\nA I-MISC\nRen I-MISC\n\" O\n( O\nPeople B-MISC\n, I-MISC\nPeople I-MISC\n) O\n, O\nwas O\ntranslated O\ninto O\nGerman B-MISC\nand O\nEnglish B-MISC\n, O\nhe O\nsaid O\n. O\n\n-DOCSTART- O\n\nHwa B-PER\nKay I-PER\nplunges O\non O\nrights O\nissue O\n, O\nearnings O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-28 O\n\nShares O\nof O\nHwa B-ORG\nKay I-ORG\nThai I-ORG\nHoldings I-ORG\nLtd I-ORG\nplunged O\nto O\nan O\nall-time O\nlow O\nafter O\nthe O\ncompany O\nannounced O\na O\nrights O\nissue O\nplan O\nand O\nalso O\nreported O\na O\nsharp O\nfall O\nin O\nearnings O\n, O\nbrokers O\nsaid O\n. O\n\nThe O\nstock O\nfell O\nHK$ B-MISC\n0.23 O\n, O\nor O\n30.26 O\npercent O\n, O\nto O\nan O\nall-time O\nlow O\nof O\nHK$ B-MISC\n0.53 O\n. O\n\n\" O\nInvestors O\nunloaded O\ntheir O\nshares O\ndue O\nto O\nthe O\npoor O\nearnings O\noutlook O\nfollowing O\na O\nsharp O\nprofit O\ndecline O\n. O\n\nThe O\nrights O\nissue O\nalso O\nprompted O\ndilution O\nfears O\n, O\n\" O\nsaid O\na O\ndealing O\ndirector O\nat O\na O\nlocal O\nbrokerage O\n. O\n\n-DOCSTART- O\n\nJapan B-LOC\nJuly O\nrefined O\nzinc O\nimports O\noff O\n47.5 O\npct O\nyr O\n/ O\nyr O\n. O\n\nTOKYO B-LOC\n1996-08-28 O\n\nJapan B-LOC\n's O\nrefined O\nzinc O\nimports O\nin O\nJuly O\ntotalled O\n3,684 O\ntonnes O\n, O\noff O\n47.5 O\npercent O\nfrom O\n7,011 O\ntonnes O\nin O\nthe O\nsame O\nmonth O\na O\nyear O\nearlier O\n, O\naccording O\nto O\nMinistry B-ORG\nof I-ORG\nFinance I-ORG\ndata O\nreleased O\non O\nWednesday O\n. O\n\nFigures O\nwere O\nas O\nfollows O\n( O\nin O\ntonnes O\n) O\n: O\n\nJuly O\n96 O\nJune O\n96 O\nJuly O\n95 O\n\nTotal O\n3,684 O\n3,292 O\n7,011 O\n\nMajor O\nsuppliers O\n: O\n\nChina B-LOC\n961 O\n1,683 O\n5,539 O\n\nRefined O\nzinc O\nimports O\nin O\nthe O\nfirst O\nseven O\nmonths O\nof O\n1996 O\ntotalled O\n115,941 O\ntonnes O\n, O\nup O\n38.4 O\npercent O\nfrom O\n83,801 O\ntonnes O\nin O\nthe O\nyear-ago O\nperiod O\n. O\n\n-- O\nTokyo B-ORG\nCommodities I-ORG\nDesk I-ORG\n( O\n813 O\n3432 O\n6179 O\n) O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nHK B-LOC\nnewspaper O\neditorials O\n- O\nAug O\n28 O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-28 O\n\nWith O\n307 O\ndays O\nto O\ngo O\nbefore O\nthe O\nBritish B-MISC\ncolony O\nreverts O\nto O\nChina B-LOC\n, O\nthe O\nHong B-LOC\nKong I-LOC\nmedia O\nfocused O\nmainly O\non O\ndomestic O\nissues O\nconcerning O\nalleged O\npressure O\non O\na O\njudge O\n, O\ncross O\nstraights O\nrelations O\nand O\nthe O\ndemocratic O\nlobby O\n's O\nrelationship O\nwith O\nBeijing B-LOC\n. O\n\nThe O\nBeijing-funded B-MISC\nWEN B-ORG\nWEI I-ORG\nPO I-ORG\nsaid O\nTaiwan B-LOC\n's O\ngovernment O\ncould O\nnot O\nhope O\nto O\nstem O\nthe O\nisland O\n's O\neconomic O\nand O\ntrade O\nexchanges O\nwith O\nChina B-LOC\n. O\n\nThe O\npaper O\nsaid O\nthat O\nusing O\nadministrative O\npower O\nto O\nlimit O\neconomic O\nactivities O\nacross O\nthe O\nTaiwan B-LOC\nstrait O\nwould O\nnot O\nwork O\n. O\n\nMING B-ORG\nPAO I-ORG\nDAILY I-ORG\nNEWS I-ORG\nsaid O\nit O\nhoped O\nChinese B-MISC\nofficials O\nwould O\nsoon O\nopen O\ndialogue O\nwith O\nHong B-LOC\nKong I-LOC\n's O\nDemocratic B-ORG\nParty I-ORG\nand O\nthe O\nnewly-established O\ndemocracy O\nlobby O\n, O\nFrontier B-ORG\n, O\nin O\norder O\nto O\nease O\nanxieties O\nin O\nthe O\nlead-up O\nto O\nthe O\nhandover O\n. O\n\nThe O\nEnglish B-MISC\nlanguage O\nSOUTH B-ORG\nCHINA I-ORG\nMORNING I-ORG\nPOST I-ORG\nsaid O\nthe O\njudiciary O\nneeded O\nto O\ntake O\nswift O\nand O\ndecisive O\naction O\nin O\ninvestigating O\nthe O\nallegations O\nthat O\na O\njudge O\nhad O\nbeen O\nsubjected O\nto O\npressure O\nin O\na O\nNew B-LOC\nZealand I-LOC\nimmigration O\ncase O\ninvolving O\nallegations O\nof O\nfraud O\n. O\n\nThe O\nindependence O\nof O\nthe O\njudiciary O\nand O\nthe O\nrule O\nof O\nlaw O\nwere O\nof O\nparamount O\nimportance O\nto O\nHong B-LOC\nKong I-LOC\n's O\nsurvival O\nas O\na O\nbusiness O\ncentre O\n. O\n\nThe O\nChinese B-MISC\nlanguage O\ndaily O\nHONG B-ORG\nKONG I-ORG\nECONOMIC I-ORG\nTIMES I-ORG\nsaid O\nthe O\nLegal B-ORG\nDepartment I-ORG\nhad O\nbeen O\nindecisive O\nin O\nits O\nhandling O\nof O\nthe O\njudge O\n's O\ncase O\n. O\n\nSuch O\nhesitancy O\non O\nthe O\npart O\nof O\nthe O\ngovernment O\nhad O\ndamaged O\npublic O\nconfidence O\nin O\nthe O\nrule O\nof O\nlaw O\n, O\nthe O\npaper O\nsaid O\n. O\n\n-- O\nHong B-LOC\nKong I-LOC\nnewsroom O\n( O\n852 O\n) O\n2843 O\n6441 O\n\n-DOCSTART- O\n\nPalestinian B-ORG\nAuthority I-ORG\nfrees O\nrights O\nactivist O\n. O\n\nGAZA B-LOC\n1996-08-28 O\n\nA O\nhuman O\nrights O\nactivist O\nsaid O\non O\nWednesday O\nhe O\nhad O\nbeen O\nreleased O\nafter O\nmore O\nthan O\ntwo O\nweeks O\nin O\ndetention O\nthat O\nfollowed O\nhis O\ncall O\nfor O\nan O\ninquiry O\ninto O\nthe O\ndeath O\nof O\na O\nGaza B-LOC\nman O\ninterrogated O\nby O\nPalestinian B-MISC\npolice O\n. O\n\nMohammad B-PER\nDahman I-PER\n, O\ndirector O\nof O\nthe O\nGaza-based B-MISC\nAddameer B-ORG\nPrisoners I-ORG\nSupport I-ORG\nAssociation I-ORG\n, O\nsaid O\nhe O\nwas O\nfreed O\non O\nTuesday O\nwithout O\nbeing O\ncharged O\n. O\n\nPalestinian B-MISC\nAttorney-General O\nKhaled B-PER\nal-Qidra I-PER\nwas O\nnot O\nimmediately O\navailable O\nto O\ncomment O\n. O\n\nQidra B-PER\nhad O\nsaid O\nDahman B-PER\nwas O\narrested O\non O\nsuspicion O\nof O\nmaking O\na O\nfalse O\nstatement O\n. O\n\nThe O\nactivist O\nwas O\ndetained O\nby O\nPalestinian B-MISC\nintelligence O\nservice O\nagents O\non O\nAugust O\n12 O\nafter O\npublishing O\na O\nstatement O\ndemanding O\nan O\ninvestigation O\ninto O\nthe O\ndeath O\nof O\na O\nGaza B-LOC\nman O\nwho O\nhad O\nbeen O\nquestioned O\nby O\nPalestinian B-MISC\nauthorities O\n. O\n\nThe O\nPalestinian B-ORG\nAuthority I-ORG\nsaid O\nthe O\ndead O\nman O\n, O\nNahed B-PER\nDahlan I-PER\n, O\nhad O\ncommitted O\nsuicide O\n. O\n\nHuman O\nrights O\ngroups O\nhad O\nprotested O\nabout O\nDahman B-PER\n's O\narrest O\nin O\nletters O\nto O\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\nand O\nto O\nQidra B-PER\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nSpain B-LOC\n- O\nAug O\n28 O\n. O\n\nHeadlines O\nfrom O\nmajor O\nnational O\nnewspapers O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nEL B-ORG\nPAIS I-ORG\n\n- O\nWork O\ngroups O\nand O\nweekend O\narrest O\nto O\nquell O\njuvenile O\nviolence O\nin O\nBasque B-LOC\nCountry I-LOC\n\nEL B-ORG\nMUNDO I-ORG\n\n- O\nAleix B-PER\nVidal-Quadras I-PER\n- O\nCatalan B-MISC\nnationalists O\nare O\ndemanding O\nmy O\ndefenestration O\n\nDIARIO B-ORG\n16 I-ORG\n\n- O\nCatalan B-MISC\nnationalists O\nsay O\nthe O\n1997 O\nbudget O\nwill O\nmake O\nSpaniards O\nsweat O\n\nABC B-ORG\n\n- O\nWorldwide O\nalarm O\nover O\nchild O\nprostitution O\n\nCINCO B-ORG\nDIAS I-ORG\n\n- O\nBanco B-ORG\nSantander I-ORG\nstarts O\nconquest O\nof O\nthe O\neast O\n. O\n\nEXPANSION B-ORG\n\n- O\nGovernment O\nwill O\nfinish O\npension O\nreform O\nbefore O\nthe O\nyear O\n2000 O\n\nGACETA B-ORG\nDE I-ORG\nLOS I-ORG\nNEGOCIOS I-ORG\n\n- O\nCaja B-ORG\nde I-ORG\nMadrid I-ORG\nstagnates O\nduring O\nstruggle O\nfor O\npresidency O\n\n-DOCSTART- O\n\nIran B-LOC\nasks O\nBonn B-LOC\nto O\nextradite O\nex-president O\nBanisadr B-PER\n. O\n\nBONN B-LOC\n1996-08-28 O\n\nIran B-LOC\nhas O\nasked O\nGermany B-LOC\nto O\nextradite O\nits O\nformer O\npresident O\nAbolhassan B-PER\nBanisadr I-PER\nfor O\nalleged O\nhijacking O\n, O\nan O\nIranian B-MISC\nembassy O\nspokesman O\nsaid O\non O\nWednesday O\n. O\n\nBanisadr B-PER\nangered O\nTehran B-LOC\nlast O\nweek O\nby O\naccusing O\ntop O\nIranian B-MISC\nleaders O\nof O\nordering O\nthe O\nassassination O\nof O\nIranian B-MISC\nKurdish I-MISC\nleaders O\nin O\na O\nBerlin B-LOC\nrestaurant O\nin O\n1992 O\n. O\n\nHe O\nmade O\nthe O\nallegations O\nat O\nthe O\ntrial O\nof O\nan O\nIranian B-MISC\nand O\nfour O\nLebanese B-MISC\naccused O\nof O\ncarrying O\nout O\nthe O\nattack O\n. O\n\nAn O\nIranian B-MISC\nembassy O\nspokesman O\nsaid O\nin O\nresponse O\nto O\nan O\ninquiry O\nthat O\nIran B-LOC\nhad O\nformally O\nrequested O\nBanisadr B-PER\n's O\nextradition O\nfor O\nhijacking O\nthe O\nmilitary O\naircraft O\nwhich O\nhe O\ncommandeered O\nto O\nflee O\nIran B-LOC\nin O\nJuly O\n1981 O\n. O\n\n\" O\nWe O\nsubmitted O\nthe O\nrequest O\nthree O\nor O\nfour O\ndays O\nago O\n, O\n\" O\nhe O\nsaid O\n. O\n\nGerman B-MISC\nauthorities O\ncould O\nnot O\nimmediately O\nbe O\nreached O\nfor O\ncomment O\n. O\n\nBanisadr B-PER\nlives O\nunder O\nround-the-clock O\nsecurity O\nin O\nFrance B-LOC\n, O\nfearing O\nTehran B-LOC\ncould O\nmake O\nan O\nattempt O\non O\nhis O\nlife O\n. O\n\nHe O\nis O\ndue O\nback O\nin O\nBerlin B-LOC\non O\nSeptember O\n5 O\nto O\ncontinue O\nhis O\ntestimony O\n, O\nwhich O\nhas O\nbacked O\nup O\nGerman B-MISC\nprosecutors O\n' O\nallegations O\nthat O\nTehran B-LOC\nordered O\nthe O\nattack O\non O\nthe O\nexiled O\nleaders O\n. O\n\nThree O\ndissidents O\nand O\ntheir O\ntranslator O\nwere O\nkilled O\nin O\nthe O\ngangland-style O\nmachinegun O\nattack O\n. O\n\nIran B-LOC\nhas O\nwarned O\nGermany B-LOC\nthat O\nbilateral O\nrelations O\ncould O\nsuffer O\nif O\nit O\npays O\nheed O\nto O\nthe O\ntestimony O\nof O\nBanisadr B-PER\n, O\nan O\narchitect O\nof O\nIran B-LOC\n's O\nIslamic B-MISC\nrevolution O\nwho O\nhas O\nbeen O\na O\nsworn O\nenemy O\nof O\nTehran B-LOC\nsince O\nhe O\nfell O\nfrom O\nfavour O\nafter O\na O\nyear O\nas O\npresident O\n. O\n\n-DOCSTART- O\n\nNATO B-ORG\nmilitary O\nchiefs O\nto O\nvisit O\nIberia B-ORG\n. O\n\nBRUSSELS B-LOC\n1996-08-28 O\n\nTop O\nmilitary O\nofficials O\nfrom O\nNorth B-ORG\nAtlantic I-ORG\nTreaty I-ORG\nOrganisation I-ORG\ncountries O\nwill O\ntour O\nSpain B-LOC\nand O\nPortugal B-LOC\nnext O\nmonth O\nfor O\ntheir O\nannual O\ninspection O\nof O\nalliance O\ncountry O\ninstallations O\nand O\nforces O\n. O\n\nNATO B-ORG\nsaid O\nin O\na O\nstatement O\nreceived O\non O\nWednesday O\nthat O\nits O\nmilitary O\ncommittee O\nwould O\nvisit O\nthe O\ntwo O\ncountries O\nbetween O\nSeptember O\n8 O\nand O\n13 O\n. O\n\nThe O\ncommittee O\nconsists O\nof O\nthe O\nchiefs O\nof O\ndefence O\nstaff O\nof O\neach O\nalliance O\ncountry O\nexcept O\nIceland B-LOC\n, O\nwhich O\nhas O\nno O\narmed O\nforces O\n. O\n\nNATO B-ORG\n's O\ntop O\nmilitary O\nmen O\n-- O\nGeneral O\nGeorge B-PER\nJoulwan I-PER\n, O\nSupreme O\nAllied O\nCommander O\nEurope B-LOC\n, O\nand O\nGeneral O\nJohn B-PER\nSheehan I-PER\n, O\nSupreme O\nAllied O\nCommander O\nAtlantic B-LOC\n-- O\nwill O\nalso O\nattend O\n. O\n\nThe O\ncommittee O\n's O\nlast O\ntour O\nwas O\nin O\nSeptember O\n1995 O\nin O\nBelgium B-LOC\n, O\nLuxembourg B-LOC\nand O\nthe O\nNetherlands B-LOC\n. O\n\nREUTER B-PER\n\n-DOCSTART- O\n\nISS B-ORG\nsays O\nagreed O\nsale O\nof O\nU.S. B-LOC\nunit O\n. O\n\nCOPENHAGEN B-LOC\n1996-08-28 O\n\nDanish B-MISC\ncleaning O\ngroup O\nISS B-ORG\non O\nWednesday O\nsaid O\nit O\nhad O\nsigned O\na O\nletter O\nof O\nintent O\nto O\nsell O\nits O\ntroubled O\nU.S B-LOC\nunit O\nISS B-ORG\nInc I-ORG\nto O\nCanadian B-MISC\nfirm O\nAaxis B-ORG\nLimited I-ORG\n. O\n\nAn O\nISS B-ORG\nstatement O\nsaid O\nthat O\nAaxis B-ORG\n, O\nwith O\nyear-end O\n1996 O\nassets O\nof O\nUS$ B-MISC\n10.9 O\nmillion O\nand O\nequity O\nof O\n$ O\n10.5 O\nmillion O\n, O\nwould O\nbe O\nlisted O\non O\nthe O\nMontreal B-LOC\nstock O\nexchange O\n, O\nbut O\ndid O\nnot O\nsay O\nwhen O\n. O\n\nIt O\nsaid O\nthat O\nunder O\nthe O\nsale O\nagreement O\n, O\nfull O\nfinancial O\ndetails O\nof O\nwhich O\nwere O\nnot O\nrevealed O\n, O\nISS B-ORG\nwould O\nacquire O\na O\n25 O\npercent O\nstake O\nin O\nAaxis B-ORG\nwhich O\nwould O\nbecome O\nan O\nassociated O\ncompany O\nwithin O\nthe O\nISS B-ORG\ngroup O\ntrading O\nunder O\nthe O\nISS B-ORG\nname O\nand O\nlogo O\n. O\n\nISS B-ORG\nInc I-ORG\nsenior O\nmanagement O\nwould O\ncontinue O\nto O\nrun O\nthe O\nbusiness O\nunder O\nthe O\nnew O\nowners O\n, O\nit O\nsaid O\n. O\n\nDanish B-MISC\nanalysts O\nrecently O\nestimated O\nISS B-ORG\nInc I-ORG\n's O\nsale O\nvalue O\nat O\nup O\nto O\n$ O\n118 O\nmillion O\n. O\n\nISS B-ORG\nsaid O\nthat O\nthe O\ndeal O\nincluded O\nISS B-ORG\nInc I-ORG\noperations O\nin O\nMexico B-LOC\nand O\nthe O\nsale O\nof O\nISS B-ORG\nInc I-ORG\ninterests O\nin O\nBrazil B-LOC\nwould O\nbe O\ndiscussed O\n. O\n\nOn O\nAugust O\n15 O\n, O\nISS B-ORG\npublished O\nfirst O\nhalf O\n1996 O\nresults O\nshowing O\na O\ntwo O\nbillion O\ncrown O\nloss O\ncaused O\nby O\nfalsified O\naccounts O\nin O\nISS B-ORG\nInc I-ORG\nand O\nsaid O\nthat O\ncharges O\nand O\nprovisions O\nearlier O\nestimated O\nat O\n$ O\n100 O\nmillion O\nwould O\nhave O\nto O\nbe O\nincreased O\nto O\n$ O\n146 O\nmillion O\n. O\n\nIt O\nalso O\nwrote O\ndown O\nall O\nISS B-ORG\nInc I-ORG\ngoodwill O\nand O\nWednesday O\n's O\nstatement O\nsaid O\nthat O\nthe O\nAaxis B-ORG\npurchase O\nwould O\nnot O\nnecessitate O\nfurther O\nwrite O\ndown O\nif O\nthe O\nsale O\nwere O\ncompleted O\naccording O\nto O\nthe O\nterms O\nof O\nthe O\nletter O\nof O\nintent O\n. O\n\n-- O\nSteve B-PER\nWeizman I-PER\n, O\nCopenhagen B-LOC\nnewsroom O\n+45 O\n33969650 O\n\n-DOCSTART- O\n\nIraq B-LOC\nbalks O\nat O\nU.N. B-ORG\nstaff O\nfor O\noil-for-food O\ndeal O\n. O\n\nEvelyn B-PER\nLeopold I-PER\n\nUNITED B-ORG\nNATIONS I-ORG\n1996-08-28 O\n\nIraq B-LOC\nhas O\nbalked O\nat O\nthe O\nnumber O\nof O\nU.N. B-ORG\nstaff O\nneeded O\nto O\nimplement O\nthe O\noil-for-food O\ndeal O\n, O\nblaming O\nthe O\nUnited B-LOC\nStates I-LOC\nfor O\ninsisting O\non O\nstringent O\nmonitoring O\n. O\n\nIn O\ncomments O\nto O\nreporters O\nand O\na O\nstatement O\non O\nTuesday O\n, O\nIraqi B-MISC\ndiplomats O\nsaid O\nthe O\ncost O\nof O\nthe O\nmonitors O\nand O\nother O\nstaff O\n, O\nwhich O\nBaghdad B-LOC\nhas O\nto O\nfinance O\n, O\nsurpasses O\nfunds O\nallocated O\nfor O\nelectricity O\n, O\nwater O\n, O\nsewers O\n, O\neducation O\nand O\nagriculture O\n. O\n\nAt O\nissue O\nwas O\na O\nMay O\n20 O\nagreement O\nallowing O\nIraq B-LOC\nto O\nsell O\n$ O\n2 O\nbillion O\nworth O\nof O\noil O\nto O\npurchase O\nbadly O\nneeded O\nfood O\n, O\nmedicine O\nand O\nother O\nsupplies O\nto O\nease O\nthe O\nimpact O\nof O\nsanctions O\nin O\nforce O\nsince O\nits O\ntroops O\ninvaded O\nKuwait B-LOC\nin O\nAugust O\n1990 O\n. O\n\nThe O\nIraqi B-MISC\nstatement O\nsaid O\nthe O\nUnited B-LOC\nStates I-LOC\nwas O\n\" O\ninterfering O\nand O\npressing O\nto O\naugment O\nthe O\nnumber O\nof O\ninternational O\nstaff O\nand O\nthis O\nis O\nnot O\nlegal O\nand O\nnot O\njustified O\n. O\n\" O\n\nIraq B-LOC\n's O\ndeputy O\nambassador O\n, O\nSaeed B-PER\nHasan I-PER\n, O\nnoted O\nthat O\nthe O\nMay O\n20 O\naccord O\nsaid O\nthat O\nthe O\nnumber O\nof O\npersonnel O\nwould O\nbe O\ndetermined O\nby O\nthe O\nUnited B-ORG\nNations I-ORG\nand O\nthat O\nthe O\ngovernment O\nof O\nIraq B-LOC\nwould O\nbe O\nconsulted O\n. O\n\nSaeed B-PER\nin O\nhis O\ncomments O\ndid O\nnot O\nthreaten O\nto O\ncall O\noff O\nthe O\ndeal O\nand O\nthe O\nU.N. B-ORG\nofficials O\nsaid O\nthey O\nexpected O\nit O\nto O\ngo O\ninto O\nforce O\nnext O\nmonth O\nafter O\nSecretary-General O\nBoutros B-PER\nBoutros-Ghali I-PER\nreports O\nthat O\narrangements O\nare O\nin O\nplace O\n. O\n\nThe O\nU.N. B-ORG\nDepartment I-ORG\nof I-ORG\nHumanitarian I-ORG\nAffairs I-ORG\n( O\nDHA B-ORG\n) O\n, O\nwhich O\nhas O\nto O\ncoordinate O\nthe O\ndistribution O\nof O\nfood O\n, O\nmedicine O\nand O\nother O\ngoods O\n, O\nincreased O\nthe O\nnumber O\nof O\nmonitors O\nearlier O\nthis O\nmonth O\nat O\nthe O\ninsistence O\nof O\nthe O\nUnited B-LOC\nStates I-LOC\n. O\n\nAccording O\nto O\nU.N. B-ORG\nofficials O\nand O\ndiplomats O\n, O\nIraq B-LOC\nwould O\nhave O\nabout O\n$ O\n1.13 O\nbillion O\nto O\nspend O\nfor O\nfood O\n, O\nmedicine O\nand O\nother O\ngoods O\nafter O\nmonies O\nfor O\na O\nreparations O\nfund O\nfor O\nGulf B-MISC\nWar I-MISC\nvictims O\nand O\ncosts O\nfor O\nU.N. B-ORG\nweapons O\ninspections O\nwere O\ndeducted O\n. O\n\nThe O\ncost O\nof O\nthe O\nU.N. B-ORG\nstaff O\noverseeing O\nthe O\ndistribution O\nof O\nfood O\nand O\nother O\nsupplies O\nwas O\nestimated O\nto O\ncost O\n$ O\n31 O\nmillion O\n. O\n\nIn O\naddition O\nanother O\n$ O\n12 O\nmillion O\nwas O\nanticipated O\nto O\ncover O\nother O\nexpenses O\n, O\nsuch O\nas O\noil O\nexperts O\nand O\nadministrative O\ncosts O\n. O\n\nFor O\nthe O\ndistribution O\nand O\nsupervision O\nof O\nhumanitarian O\nsupplies O\nthe O\nUnited B-ORG\nNations I-ORG\nestimated O\nit O\nneeded O\n1,190 O\npeople O\n, O\nincluding O\n267 O\ninternational O\nstaff O\nand O\n923 O\nIraqi B-MISC\nsupport O\nstaff O\n. O\n\nOf O\nthis O\nnumber O\n64 O\nforeign O\nand O\n598 O\nlocal O\nstaff O\nwould O\nbe O\nin O\nthe O\nnorthern O\nKurdish B-MISC\nprovinces O\n, O\nno O\nlonger O\nthe O\ndirect O\ncontrol O\nof O\nthe O\nBaghdad B-LOC\ngovernment O\n. O\n\nAnother O\n203 O\ninternational O\nstaff O\nand O\n325 O\nIraqis B-MISC\nwould O\nrun O\nthe O\nprogramme O\nin O\nthe O\ncentral O\nand O\nsouthern O\nparts O\nof O\nthe O\ncountry O\n. O\n\nThere O\nare O\nalso O\n14 O\nmonitors O\nto O\nwatch O\noil O\nflows O\n, O\n32 O\ncustoms O\nexperts O\nand O\nfour O\nNew B-MISC\nYork-based I-MISC\noil O\nexperts O\nor O\noverseers O\nto O\napprove O\ncontracts O\n. O\n\nYasushi B-PER\nAkashi I-PER\n, O\nthe O\nDHA B-ORG\nundersecretary-general O\n, O\ntold O\nthe O\nSecurity B-ORG\nCouncil I-ORG\nlast O\nweek O\nthat O\nthe O\n\" O\nfinancial O\nrequirements O\nto O\nsupport O\nthe O\n( O\nhumanitarian O\n) O\nprogramme O\nrepresent O\na O\nvery O\nmodest O\npercentile O\nof O\nthe O\ntotal O\n... O\n\nroughly O\n3 O\npercent O\n. O\n\" O\n\n-DOCSTART- O\n\nOFFICIAL B-ORG\nJOURNAL I-ORG\nCONTENTS O\n- O\nOJ B-ORG\nC O\n251 O\nOF O\nAUGUST O\n29 O\n, O\n1996 O\n. O\n\n* O\n\n( O\nNote O\n- O\ncontents O\nare O\ndisplayed O\nin O\nreverse O\norder O\nto O\nthat O\nin O\nthe O\nprinted O\nJournal B-ORG\n) O\n\n* O\n\nAircraft O\nnoise O\nand O\nemissions O\nEconomic O\nassessment O\nof O\nproposals O\nfor O\na O\ncommon O\nEuropean B-ORG\nUnion I-ORG\nposition O\nfor O\nCAEP O\n4 O\nConsultancy O\nservices O\nCall O\nfor O\ntender O\n( O\n96 O\n/ O\nC O\n251/09 O\n) O\n\nProvision O\nof O\noverland O\ntransport O\nservices O\nfor O\nmaterial O\nand O\nequipment O\nfor O\nEuropean B-ORG\nCommission I-ORG\ndelegations O\nin O\nEuropean B-MISC\nThird I-MISC\nCountries I-MISC\nand O\nin O\nthe O\nNew B-MISC\nIndependent I-MISC\nStates I-MISC\n( O\nNIS B-MISC\n) O\nContract O\nnotice O\nNo O\nTRA O\n/ O\n96 O\n/ O\n003 O\n/ O\nIAE-3 O\n- O\nOpen O\nprocedure O\n( O\n96 O\n/ O\nC O\n251/08 O\n) O\n\nMicrofiche O\nproduction O\nsystem O\nOpen O\nprocedure O\nInvitation O\nto O\ntender O\nDI O\n96/04 O\nMicromation O\n( O\n96 O\n/ O\nC O\n251/07 O\n) O\n\nAircraft O\nnoise O\nand O\nemissions O\nGaseous O\nemissions O\nfrom O\naircraft O\nin O\nthe O\natmosphere O\nConsultancy O\nservices O\nCall O\nfor O\ntender O\n( O\n96 O\n/ O\nC O\n251/06 O\n) O\n\nTacis B-MISC\n- O\nsupport O\nframework O\nfor O\nthe O\ncoordination O\nand O\ndevelopment O\nof O\nthe O\nTacis B-MISC\ninformation O\nand O\ncommunications O\nprogramme O\nNotice O\nof O\nopen O\ninvitation O\nto O\ntender O\nfor O\na O\npublic O\nservice O\ncontract O\n( O\n96 O\n/ O\nC O\n251/05 O\n) O\n\nCOUNCIL O\nREGULATION O\n( O\nEEC B-ORG\n) O\nNo O\n4064/89 O\n( O\n96 O\n/ O\nC O\n251/04 O\n) O\n\nFINANCIAL O\nSTATEMENTS O\nOF O\nTHE O\nEUROPEAN B-MISC\nCOAL O\nAND O\nSTEEL O\nCOMMUNITY O\nAT O\n31 O\nDECEMBER O\n1995 O\n( O\n96 O\n/ O\nC O\n251/03 O\n) O\n\nAverage O\nprices O\nand O\nrepresentative O\nprices O\nfor O\ntable O\nwines O\nat O\nthe O\nvarious O\nmarketing O\ncentres O\n( O\n96 O\n/ O\nC O\n251/02 O\n) O\n\nEcu B-MISC\n( O\n1 O\n) O\n28 O\nAugust O\n1996 O\n( O\n96 O\n/ O\nC O\n251/01 O\n) O\nEND O\nOF O\nDOCUMENT O\n. O\n\n-DOCSTART- O\n\nEU B-ORG\nCommission I-ORG\ncool O\non O\nchanging O\nbeef O\ncull O\nplan O\n. O\n\nBRUSSELS B-LOC\n1996-08-29 O\n\nThe O\nEuropean B-ORG\nCommission I-ORG\nsaid O\non O\nThursday O\nit O\nwould O\nstudy O\nscientific O\nreports O\nsaying O\nBritain B-LOC\n's O\nmad O\ncow O\nepidemic O\nwould O\ndie O\nout O\nby O\n2001 O\nbut O\noffered O\nlittle O\nprospect O\nthe O\nfindings O\nwould O\nchange O\nan O\nagreed O\nslaughter O\ncampaign O\n. O\n\n\" O\nObviously O\nwe O\nare O\ninterested O\nin O\nthis O\nresearch O\n. O\n\nWe O\nwill O\nask O\nthe O\n( O\nEU B-ORG\n) O\nscientific O\nand O\nveterinary O\ncommittee O\nto O\nexamine O\nit O\n, O\n\" O\nCommission B-ORG\nspokesman O\nGerard B-PER\nKiely I-PER\ntold O\nReuters B-ORG\n. O\n\nBut O\nhe O\nadded O\nthat O\nnew O\nresearch O\ninto O\nthe O\ndynamics O\nof O\nthe O\nbovine O\nspongiform O\nencephalopathy O\n( O\nBSE B-MISC\n) O\n, O\na O\nfatal O\nbrain-wasting O\ndisease O\nsuffered O\nby O\ncattle O\n, O\nwas O\nunlikely O\nto O\nalter O\na O\nslaughter O\nplan O\nagreed O\nby O\nBritain B-LOC\nand O\nits O\n14 O\nEU B-ORG\npartners O\n. O\n\n\" O\nWe O\nagreed O\nthat O\nfollowing O\ndetailed O\nscientific O\nanalysis O\nusing O\na O\nmethodology O\nwhich O\nwould O\ntake O\nout O\nthe O\nmaximum O\nnumber O\nof O\nBSE B-MISC\ncases O\npossible O\n. O\n\nI O\nthink O\nit O\nwould O\nbe O\nvery O\ndifficult O\nto O\nsell O\nto O\nthe O\nEuropean B-ORG\nCommission I-ORG\na O\nprogramme O\nwhich O\nwould O\ninvolve O\nthe O\nelimination O\nof O\nfewer O\nBSE B-MISC\ncases O\n, O\n\" O\nKiely B-PER\nsaid O\n. O\n\n\" O\nWe O\nwill O\nlook O\nat O\nour O\napproach O\n( O\nto O\nthe O\nplan O\n) O\nbut O\nwe O\nwo O\nn't O\nget O\ninvolved O\nwith O\nthe O\nnumber O\nof O\nanimals O\nto O\nbe O\nslaughtered O\n, O\n\" O\nhe O\nsaid O\n. O\n\n\" O\nWe O\nhave O\nalways O\navoided O\nthe O\nquestion O\nof O\nnumbers O\nof O\nanimals O\nto O\nbe O\nslaughtered O\n, O\nthat O\n's O\nnot O\nthe O\nissue O\n. O\n\nThe O\nissue O\nis O\nthe O\nprotection O\nof O\nconsumers O\n' O\nhealth O\nand O\nthe O\nrapid O\neradication O\nof O\nBSE B-MISC\n, O\n\" O\nhe O\nadded O\n. O\n\nThe O\nreaction O\nis O\nlikely O\nto O\ndisappoint O\nBritish B-MISC\nfarmers O\n, O\nwho O\nseized O\non O\nresearch O\nby O\nOxford B-ORG\nscientists O\nin O\nthe O\nscientific O\njournal O\nNature B-ORG\nsaying O\nit O\nwould O\nbe O\nhard O\nto O\nget O\nrid O\nof O\nthe O\ndisease O\nany O\nfaster O\nthan O\n2001 O\nwithout O\nkilling O\nvast O\nnumbers O\nof O\ncattle O\n. O\n\nThe O\nresearchers O\npredicted O\nthere O\nwould O\nbe O\n340 O\nnew O\ninfections O\nand O\n14,000 O\nnew O\ncases O\nof O\nBSE B-MISC\nbefore O\n2001 O\n. O\n\nBritish B-MISC\nfarmers O\n' O\nleader O\ncalled O\non O\nWednesday O\nfor O\nan O\nurgent O\nmeeting O\nwith O\nministers O\nto O\ndiscuss O\nthe O\nreport O\n. O\n\n\" O\nI O\nhope O\nthe O\ngovernment O\nwill O\nnow O\nmake O\nit O\nclear O\nthey O\nbelieve O\nthere O\nis O\na O\nbetter O\nway O\nof O\ndealing O\nwith O\nthis O\nissue O\n, O\n\" O\nNational B-ORG\nFarmers I-ORG\nUnion I-ORG\npresident O\nSir O\nDavid B-PER\nNaish I-PER\ntold O\nBBC B-ORG\nradio I-ORG\n. O\n\nNaish B-PER\nsaid O\nthere O\nwas O\nno O\nneed O\nfor O\nBritain B-LOC\nto O\ncarry O\nout O\na O\nplanned O\ncull O\nof O\nsome O\n147,000 O\ncattle O\nto O\nwhich O\nit O\nhad O\nreluctantly O\nagreed O\nto O\nplacate O\nits O\nEuropean B-MISC\npartners O\n. O\n\n\" O\nThe O\nnew O\nevidence O\nto O\nme O\nmeans O\nsome O\nof O\nthat O\nproposal O\nshould O\nbe O\nre-examined O\nbecause O\nwe O\ncould O\nget O\naway O\nwith O\nconsiderably O\nless O\nanimals O\nbeing O\nculled O\nif O\nin O\nfact O\nscientists O\nthroughout O\nEurope B-LOC\naccepted O\nthis O\nevidence O\n, O\n\" O\nNaish B-PER\nsaid O\n. O\n\nThe O\nreport O\ncould O\nwell O\nreopen O\na O\ndamaging O\nrow O\nbetween O\nBritain B-LOC\nand O\nthe O\nEU B-ORG\n, O\nwhich O\nslapped O\na O\nworldwide O\nban O\non O\nBritish B-MISC\nbeef O\nafter O\nthe O\ngovernment O\nsaid O\nthere O\ncould O\nbe O\na O\nlink O\nbetween O\nBSE B-MISC\nand O\nthe O\nhuman O\nform O\nof O\nthe O\ndisease O\n. O\n\nThe O\nissue O\nflared O\nin O\nin O\nMarch O\nwhen O\ngovernment O\nscientists O\nadmitted O\nthat O\npeople O\ncould O\nbecome O\ninfected O\nwith O\nCreutzfeldt-Jakob B-MISC\nDisease I-MISC\n( O\nCJD B-MISC\n) O\nfrom O\neating O\nBSE-infected B-MISC\nbeef O\n. O\n\n-DOCSTART- O\n\nFrench B-MISC\nfarmers O\nset O\nup O\nblockades O\nin O\nmad O\ncow O\nprotest O\n. O\n\nPARIS B-LOC\n1996-08-29 O\n\nThousands O\nof O\nfarmers O\nthrew O\nup O\nroadblocks O\nacross O\nFrance B-LOC\novernight O\n, O\nstopping O\nand O\nchecking O\nlorries O\nsuspected O\nof O\nimporting O\nmeat O\nfrom O\noutside O\nthe O\nEuropean B-ORG\nUnion I-ORG\n, O\nFrench B-MISC\nradios O\nreported O\non O\nThursday O\n. O\n\nRadio O\nstations O\nsaid O\naround O\n15,000 O\nfarmers O\n, O\nangered O\nby O\na O\nfall O\nin O\nbeef O\nprices O\nfollowing O\nthe O\nmad O\ncow O\ndisease O\ncrisis O\n, O\nstaged O\nprotests O\nin O\nmany O\nareas O\nand O\nblockaded O\nseveral O\nmain O\nroads O\nand O\nmotorways O\n. O\n\nBy O\n3 O\na.m. O\n( O\n0100 O\nGMT B-MISC\n) O\nmore O\nthan O\n2,000 O\nlorries O\nhad O\nbeen O\nstopped O\nand O\nsearched O\n. O\n\nEuropean B-MISC\nbeef O\nsales O\nplunged O\nafter O\nBritain B-LOC\nannounced O\nthe O\ndiscovery O\nof O\na O\nlikely O\nlink O\nbetween O\nbovine O\nspongiform O\nencephalopathy O\n( O\nBSE B-MISC\n) O\n, O\nor O\nmad O\ncow O\ndisease O\n, O\nand O\nits O\nfatal O\nhuman O\nequivalent O\nCreutzfeldt-Jakob B-MISC\nDisease I-MISC\n( O\nCJD B-MISC\n) O\n. O\n\n-DOCSTART- O\n\nGOLF B-LOC\n- O\nBRITISH B-MISC\nMASTERS I-MISC\nSECOND O\nROUND O\nSCORES O\n. O\n\nNORTHAMPTON B-LOC\n, O\nEngland B-LOC\n1996-08-29 O\n\nLeading O\nscores O\nafter O\n\nthe O\nsecond O\nround O\nof O\nthe O\nBritish B-MISC\nMasters I-MISC\non O\nThursday O\n( O\nBritish B-MISC\n\nunless O\nstated O\n) O\n: O\n\n140 O\nRobert B-PER\nAllenby I-PER\n( O\nAustralia B-LOC\n) O\n69 O\n71 O\n, O\nMark B-PER\nRoe I-PER\n69 O\n71 O\n\n141 O\nFrancisco B-PER\nCea I-PER\n( O\nSpain B-LOC\n) O\n70 O\n71 O\n, O\nGavin B-PER\nLevenson I-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n\n66 O\n75 O\n\n142 O\nDaniel B-PER\nChopra I-PER\n( O\nSweden B-LOC\n) O\n74 O\n68 O\n\n143 O\nDavid B-PER\nGilford I-PER\n69 O\n74 O\n\n144 O\nPeter B-PER\nO'Malley I-PER\n( O\nAustralia B-LOC\n) O\n71 O\n73 O\n, O\nCostantino B-PER\nRocca I-PER\n( O\nItaly B-LOC\n) O\n\n71 O\n73 O\n, O\nColin B-PER\nMontgomerie I-PER\n68 O\n76 O\n, O\nDavid B-PER\nHowell I-PER\n70 O\n74 O\n, O\nMark B-PER\n\nDavis B-PER\n71 O\n73 O\n\n145 O\nPeter B-PER\nMitchell I-PER\n74 O\n71 O\n, O\nPhilip B-PER\nWalton I-PER\n( O\nIreland B-LOC\n) O\n71 O\n74 O\n, O\nRetief B-PER\n\nGoosen B-PER\n( O\nSouth B-LOC\nAfrica I-LOC\n) O\n71 O\n74 O\n, O\nOve B-PER\nSellberg I-PER\n( O\nSweden B-LOC\n) O\n71 O\n74 O\n, O\n\nPeter B-PER\nHedblom I-PER\n( O\nSweden B-LOC\n) O\n70 O\n75 O\n, O\nPedro B-PER\nLinhart I-PER\n( O\nSpain B-LOC\n) O\n72 O\n73 O\n, O\n\nMike B-PER\nClayton I-PER\n( O\nAustralia B-LOC\n) O\n69 O\n76 O\n, O\nEmanuele B-PER\nCanonica I-PER\n( O\nItaly B-LOC\n) O\n\n69 O\n76 O\n, O\nMiguel B-PER\nAngel I-PER\nMartin I-PER\n( O\nSpain B-LOC\n) O\n75 O\n70 O\n\n146 O\nIain B-PER\nPyman I-PER\n71 O\n75 O\n, O\nEduardo B-PER\nRomero I-PER\n( O\nArgentina B-LOC\n) O\n70 O\n76 O\n, O\nIan B-PER\n\nWoosnam B-PER\n70 O\n76 O\n, O\nMiguel B-PER\nAngel I-PER\nJimenez I-PER\n( O\nSpain B-LOC\n) O\n74 O\n72 O\n, O\nKlas B-PER\n\nEriksson B-PER\n( O\nSweden B-LOC\n) O\n71 O\n75 O\n, O\nPaul B-PER\nEales I-PER\n75 O\n71 O\n\n147 O\nAntoine B-PER\nLebouc I-PER\n( O\nFrance B-LOC\n) O\n74 O\n73 O\n, O\nPaul B-PER\nCurry I-PER\n76 O\n71 O\n, O\nAndrew B-PER\n\nColtart B-PER\n72 O\n75 O\n, O\nPaul B-PER\nLawrie I-PER\n72 O\n75 O\n, O\nJose B-PER\nCoceres I-PER\n( O\nArgentina B-LOC\n) O\n\n69 O\n78 O\n, O\nRaymond B-PER\nRussell I-PER\n69 O\n78 O\n, O\nRoger B-PER\nChapman I-PER\n71 O\n76 O\n, O\nPaul B-PER\n\nAffleck B-PER\n74 O\n73 O\n. O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nSORENSEN B-PER\nWINS O\nFOURTH O\nSTAGE O\nOF O\nTOUR B-MISC\nOF I-MISC\nNETHERLANDS I-MISC\n. O\n\nDOETINCHEM B-LOC\n, O\nNetherlands B-LOC\n1996-08-29 O\n\nLeading O\nresults O\nand O\noverall O\nstandings O\nafter O\nthe O\n19.6 O\nkilometre O\nfourth O\nstage O\nof O\nthe O\nTour B-MISC\nof I-MISC\nthe I-MISC\nNetherlands I-MISC\non O\nThursday O\n, O\na O\ntime O\ntrial O\nstarting O\nand O\nfinishing O\nin O\nDoetinchem B-LOC\n. O\n\n1. O\nRolf B-PER\nSorensen I-PER\n( O\nDenmark B-LOC\n) O\nRabobank B-ORG\n22 O\nminutes O\n40 O\nseconds O\n\n2. O\nLance B-PER\nArmstrong I-PER\n( O\nU.S. B-LOC\n) O\nMotorola B-ORG\n1 O\nsecond O\nbehind O\n\n3. O\nVyacheslav B-PER\nEkimov I-PER\n( O\nRussia B-LOC\n) O\nRabobank B-ORG\n29 O\nseconds O\nbehind O\n\n4. O\nErik B-PER\nDekker I-PER\n( O\nNetherlands B-LOC\n) O\nRabobank B-ORG\n43 O\n\n5. O\nGiunluca B-PER\nGorini I-PER\n( O\nItaly B-LOC\n) O\nAki B-ORG\n45 O\n\n6. O\nErik B-PER\nBreukink I-PER\n( O\nNetherlands B-LOC\n) O\nRabobank B-ORG\n48 O\n\n7. O\nWilfried B-PER\nPeeters I-PER\n( O\nBelgium B-LOC\n) O\nMapei B-ORG\n51 O\n\n8. O\nBart B-PER\nVoskamp I-PER\n( O\nNetherlands B-LOC\n) O\nTVM B-ORG\n53 O\n\n9. O\nMichael B-PER\nAndersson I-PER\n( O\nSweden B-LOC\n) O\nTelekom B-ORG\n54 O\n\n10. O\nGregory B-PER\nRandolph I-PER\n( O\nUSA B-LOC\n) O\nMotorola B-ORG\n1 O\nminute O\n3 O\nseconds O\n\nLeading O\noverall O\nplacings O\nafter O\nthree O\nstages O\n: O\n\n1. O\nSorensen B-PER\n11.20:33 O\n\n2. O\nArmstrong B-PER\n3 O\nseconds O\nbehind O\n\n3. O\nEkimov B-PER\n1 O\nminute O\n7 O\nseconds O\n\n4. O\nMarco B-PER\nLietti I-PER\n( O\nItaly B-LOC\n) O\nMG-Technogym B-ORG\n1 O\nminute O\n14 O\nseconds O\n\n5. O\nDekker B-PER\n1 O\nminute O\n21 O\nseconds O\n\n6. O\nBreukink B-PER\n1 O\nminute O\n26 O\nseconds O\n\n7. O\nMaarten B-PER\nden I-PER\nBakker I-PER\n( O\nNetherlands B-LOC\n) O\nTVM B-ORG\n1 O\nminute O\n31 O\nseconds O\n\n8. O\nVoskamp B-PER\nsame O\ntime O\n\n9. O\nAndersson B-PER\n1 O\nminute O\n32 O\nseconds O\n\n10. O\nOlaf B-PER\nLudwig I-PER\n( O\nGermany B-LOC\n) O\nTelekom B-ORG\n1 O\nminute O\n44 O\nseconds O\n\nThe O\nrace O\ncontinues O\non O\nFriday O\nwith O\nthe O\n178 O\nkilometre O\nfifth-stage O\nfrom O\nZevenaar B-LOC\nto O\nVenray B-LOC\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nBEAT O\nPAKISTAN B-LOC\nIN O\nFIRST O\nONE-DAYER O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-29 O\n\nEngland B-LOC\nbeat O\nPakistan B-LOC\nby O\nfive O\nwickets O\nto O\nwin O\nthe O\nfirst O\none-day O\n( O\n50 O\novers-a-side O\n) O\ninternational O\nat O\nOld B-LOC\nTrafford I-LOC\non O\nThursday O\n. O\n\nScores O\n: O\nPakistan B-LOC\n225-5 O\ninnings O\nclosed O\n( O\nSaeed B-PER\nAnwar I-PER\n57 O\n) O\n, O\nEngland B-LOC\n226-5 O\nin O\n46.4 O\novers O\n( O\nM. B-PER\nAtherton I-PER\n65 O\n) O\n. O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nWORLD O\nCHAMPIONSHIP O\nRESULTS O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-29 O\n\nResults O\nat O\nthe O\nworld O\ntrack O\ncycling O\nchampionships O\non O\nThursday O\n: O\n\nIndividual O\npursuit O\nsemifinals O\n( O\nover O\n4,000 O\nmetres O\n) O\n: O\n\nChris B-PER\nBoardman I-PER\n( O\nBritain B-LOC\n) O\n4:15.006 O\nbeat O\nAlexei B-PER\nMarkov I-PER\n( O\nRussia B-LOC\n) O\n4:23.029 O\n\nAndrea B-PER\nCollinelli I-PER\n( O\nItaly B-LOC\n) O\n4:16.141 O\nbeat O\nFrancis B-PER\nMoreau I-PER\n( O\nFrance B-LOC\n) O\n4:19.665 O\n\nMoreau B-PER\ntakes O\nbronze O\nmedal O\nas O\nfaster O\nlosing O\nsemifinalist O\n. O\n\nFinal O\n: O\n\nChris B-PER\nBoardman I-PER\n( O\nBritain B-LOC\n) O\n4:11.114 O\n( O\nworld O\nrecord O\n) O\nbeat O\nAndrea B-PER\nCollinelli I-PER\n( O\nItaly B-LOC\n) O\n4:20.341 O\n\nOlympic B-MISC\nsprint O\nchampionship O\n( O\nthree-man O\nteams O\n) O\n: O\n\n1. O\nAustralia B-LOC\n( O\nDarryn B-PER\nHill I-PER\n, O\nShane B-PER\nKelly I-PER\n, O\nGary B-PER\nNeiwand I-PER\n) O\n44.804 O\n\nseconds O\n\n2. O\nGermany B-LOC\n( O\nJens B-PER\nFiedler I-PER\n, O\nMichael B-PER\nHubner I-PER\n, O\nSoren B-PER\nLausberg I-PER\n) O\n\n45.455 O\n\n3. O\nFrance B-LOC\n( O\nLaurent B-PER\nGane I-PER\n, O\nFlorian B-PER\nRousseau I-PER\n, O\nHerve B-PER\nThuet I-PER\n) O\n\n45.810 O\n\n4. O\nGreece B-LOC\n( O\nDimitrios B-PER\nGeorgalis I-PER\n, O\nGeorgios B-PER\nChimonetos I-PER\n, O\nLampros B-PER\n\nVasilopoulos B-PER\n) O\n46.538 O\n\nWomen O\n's O\nworld O\nsprint O\nchampionship O\nquarter-finals O\n( O\nbest O\nof O\n\nthree O\nmatches O\n) O\n: O\n\nMagali B-PER\nFaure I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nKathrin B-PER\nFreitag I-PER\n( O\nGermany B-LOC\n) O\ntwo O\n\nmatches O\nto O\nnil O\n( O\nwith O\ntimes O\nfor O\nthe O\nlast O\n200 O\nmetres O\nof O\n11.833 O\n\nseconds O\nand O\n12.033 O\nseconds O\n) O\n\nFelicia B-PER\nBallanger I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nOksana B-PER\nGrichina I-PER\n( O\nRussia B-LOC\n) O\n2-0 O\n, O\n\n( O\n11.776 O\n/ O\n12.442 O\n) O\n\nTanya B-PER\nDubnicoff I-PER\n( O\nCanada B-LOC\n) O\nbeat O\nMichelle B-PER\nFerris I-PER\n( O\nAustralia B-LOC\n) O\n2-0 O\n, O\n\n( O\n12.211 O\n/ O\n12.208 O\n) O\n\nAnnett B-PER\nNeumann I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nGalina B-PER\nEnioukhina I-PER\n( O\nRussia B-LOC\n) O\n2-0 O\n, O\n\n( O\n12.434 O\n/ O\n12.177). O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nCROFT B-PER\nRESTRICTS O\nPAKISTAN B-LOC\nTO O\n225-5 O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-29 O\n\nTight O\nbowling O\nfrom O\nGlamorgan B-ORG\noff-spinner O\nRobert B-PER\nCroft I-PER\nhelped O\nEngland B-LOC\nto O\nrestrict O\nPakistan B-LOC\nto O\n225 O\nfor O\nfive O\nin O\ntheir O\n50 O\novers O\nin O\nthe O\nfirst O\none-day O\ninternational O\nat O\nOld B-LOC\nTrafford I-LOC\non O\nThursday O\n. O\n\nCroft B-PER\n, O\nwho O\nwas O\none O\nof O\nthe O\nfew O\nEnglishmen B-MISC\nto O\nmake O\na O\ngood O\nimpression O\nin O\nhis O\ntest O\ndebut O\nat O\nThe B-LOC\nOval I-LOC\nlast O\nweek O\n, O\nshowed O\ngreat O\ncontrol O\nas O\nhe O\nfirst O\ndried O\nup O\nthe O\nearly O\nflow O\nof O\nPakistan B-LOC\nruns O\nand O\nthen O\ncollected O\nthe O\nwickets O\nof O\nAamir B-PER\nSohail I-PER\nand O\nWasim B-PER\nAkram I-PER\nin O\na O\nspell O\nof O\n10-1-36-2 O\n. O\n\nThere O\nwas O\nalso O\na O\nwicket O\neach O\nfor O\nRonnie B-PER\nIrani I-PER\n, O\nAllan B-PER\nMullally I-PER\nand O\nDarren B-PER\nGough I-PER\nalthough O\nthere O\nwas O\nno O\njoy O\nfor O\nDean B-PER\nHeadley I-PER\nwho O\n, O\nalong O\nwith O\nLancashire B-ORG\nbatsman O\nGraham B-PER\nLloyd I-PER\n, O\nwas O\nmaking O\nhis O\ninternational O\ndebut O\n. O\n\nAfter O\nWasim B-PER\nhad O\nwon O\nthe O\ntoss O\nand O\nchosen O\nto O\nbat O\nfirst O\n, O\nPakistani B-MISC\nmade O\nan O\nexcellent O\nstart O\nas O\nSohail B-PER\nand O\nSaeed B-PER\nAnwar I-PER\ncontinued O\ntheir O\ngood O\nform O\nwith O\nan O\nopening O\npartnership O\nof O\n82 O\n. O\n\nAnwar B-PER\n, O\nwho O\nstruck O\na O\nsuperb O\n176 O\nat O\nThe B-LOC\nOval I-LOC\n, O\nwas O\nthe O\nmore O\naggressive O\nas O\nhe O\nmade O\n57 O\nfrom O\n75 O\nballs O\nbefore O\nskying O\na O\ncatch O\noff O\nIrani B-PER\nto O\nMullally B-PER\nat O\nlong-on O\n. O\n\nSohail B-PER\nand O\nIjaz B-PER\nAhmed I-PER\nthen O\nadded O\n59 O\nfor O\nthe O\nsecond O\nwicket O\nbefore O\nEngland B-LOC\nstruck O\nback O\nwith O\nthree O\nwickets O\nfor O\n19 O\nin O\nthe O\nspace O\nof O\nfive O\novers O\n. O\n\nFirst O\n, O\nSohail B-PER\n, O\nafter O\nmaking O\n48 O\n, O\nwas O\nbowled O\nby O\nCroft B-PER\nas O\nhe O\nstepped O\nback O\nto O\ntry O\nand O\nhit O\nthrough O\nthe O\noff-side O\n. O\n\nWasim B-PER\n, O\nwho O\npromoted O\nhimself O\nto O\nnumber O\nfour O\nin O\nthe O\norder O\n, O\nfollowed O\nfor O\nsix O\nwhen O\nCroft B-PER\ndrifted O\nanother O\nwell-flighted O\ndelivery O\nbehind O\nhis O\nlegs O\n. O\n\nShortly O\nafter O\nIjaz B-PER\nwas O\nalso O\nback O\nin O\nthe O\npavilion O\nfor O\n48 O\nafter O\nIrani B-PER\nhad O\nrepaid O\nMullally B-PER\nwith O\nanother O\ngood O\ncatch O\nat O\nlong-on O\n. O\n\nGough B-PER\nlater O\nbowled O\nMoin B-PER\nKhan I-PER\nwith O\nan O\ninswinging O\nyorker O\nbut O\nInzamam-ul-Haq B-PER\n, O\n37 O\nnot O\nout O\n, O\nand O\nSalim B-PER\nMalik I-PER\ntook O\nPakistan B-LOC\nto O\n225 O\nfor O\nfive O\nwhen O\nthe O\novers O\nran O\nout O\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nV O\nPAKISTAN B-LOC\nONE-DAY O\nSCOREBOARD O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-29 O\n\nScoreboard O\nof O\nthe O\n\nfirst O\none-day O\n( O\n50 O\novers-a-side O\n) O\nmatch O\nbetween O\nEngland B-LOC\nand O\n\nPakistan B-LOC\nat O\nOld B-LOC\nTrafford I-LOC\non O\nThursday O\n: O\n\nPakistan B-LOC\n\nSaeed B-PER\nAnwar I-PER\nc O\nMullally B-PER\nb O\nIrani B-PER\n57 O\n\nAamir B-PER\nSohail I-PER\nb O\nCroft B-PER\n48 O\n\nIjaz B-PER\nAhmed I-PER\nc O\nIrani B-PER\nb O\nMullally B-PER\n48 O\n\nWasim B-PER\nAkram I-PER\nb O\nCroft B-PER\n6 O\n\nInzamam-ul-Haq B-PER\nnot O\nout O\n37 O\n\nMoin B-PER\nKhan I-PER\nb O\nGough B-PER\n10 O\n\nSalim B-PER\nMalik I-PER\nnot O\nout O\n6 O\n\nExtras O\n( O\nb-2 O\nlb-4 O\nw-7 O\n) O\n13 O\n\nTotal O\n( O\nfor O\n5 O\nwickets O\n, O\ninnings O\nclosed O\n) O\n225 O\n\nFall O\n: O\n1-82 O\n2-141 O\n3-160 O\n4-174 O\n5-203 O\n. O\n\nDid O\nNot O\nBat O\n: O\nMushtaq B-PER\nAhmed I-PER\n, O\nWaqar B-PER\nYounis I-PER\n, O\nAta-ur-Rehman B-PER\n, O\n\nSaqlain B-PER\nMushtaq I-PER\n. O\n\nBowling O\n: O\nGough B-PER\n10-0-44-1 O\n, O\nMullally B-PER\n10-3-31-1 O\n, O\nHeadley B-PER\n\n10-0-52-0 O\n, O\nIrani B-PER\n10-0-56-1 O\n, O\nCroft B-PER\n10-1-36-2 O\n. O\n\nEngland B-LOC\n\nN. B-PER\nKnight I-PER\nc O\nMoin B-PER\nKhan I-PER\nb O\nWasim B-PER\nAkram I-PER\n26 O\n\nA. B-PER\nStewart I-PER\nlbw O\nb O\nWaqar B-PER\nYounis I-PER\n48 O\n\nM. B-PER\nAtherton I-PER\nb O\nWasim B-PER\nAkram I-PER\n65 O\n\nG. B-PER\nThorpe I-PER\nst O\nMoin B-PER\nKhan I-PER\nb O\nAamir B-PER\nSohail I-PER\n23 O\n\nM. B-PER\nMaynard I-PER\nb O\nWasim B-PER\nAkram I-PER\n41 O\n\nG. B-PER\nLloyd I-PER\nnot O\nout O\n2 O\n\nR. B-PER\nIrani I-PER\nnot O\nout O\n6 O\n\nExtras O\n( O\nlb-4 O\nw-7 O\nnb-4 O\n) O\n15 O\n\nTotal O\n( O\nfor O\n5 O\nwickets O\n, O\n46.4 O\novers O\n) O\n226 O\n\nFall O\nof O\nwickets O\n: O\n1-57 O\n2-98 O\n3-146 O\n4-200 O\n5-220 O\n. O\n\nDid O\nnot O\nbat O\n: O\nR. B-PER\nCroft I-PER\n, O\nD. B-PER\nGough I-PER\n, O\nD. B-PER\nHeadley I-PER\n, O\nA. B-PER\nMullally I-PER\n. O\n\nBowling O\n: O\nWasim B-PER\nAkram I-PER\n9.4-1-45-3 O\n, O\nWaqar B-PER\nYounis I-PER\n7-0-28-1 O\n, O\n\nSaqlain B-PER\nMushtaq I-PER\n10-1-54-0 O\n, O\nAta-ur-Rehman B-PER\n3-0-14-0 O\n, O\nMushtaq B-PER\nAhmed I-PER\n\n10-0-52-0 O\n, O\nAamir B-PER\nSohail I-PER\n7-1-29-1 O\n. O\n\nResult O\n: O\nEngland B-LOC\nwon O\nby O\nfive O\nwickets O\n. O\n\nSecond O\nmatch O\n: O\nAugust O\n31 O\n, O\nEdgbaston B-LOC\n( O\nBirmingham B-LOC\n) O\n\nThird O\n: O\nSeptember O\n1 O\n, O\nTrent B-LOC\nBridge I-LOC\n( O\nNottingham B-LOC\n) O\n\n-DOCSTART- O\n\nLOMBARDI B-PER\nWINS O\nTHIRD O\nSTAGE O\nOF O\nTOUR B-MISC\nOF I-MISC\nNETHERLANDS I-MISC\n. O\n\nDOETINCHEM B-LOC\n, O\nNetherlands B-LOC\n1996-08-29 O\n\nLeading O\nresults O\nand O\noverall O\nstandings O\nafter O\nthe O\n122 O\nkilometre O\nthird O\nstage O\nof O\nthe O\nTour B-MISC\nof I-MISC\nthe I-MISC\nNetherlands I-MISC\non O\nThursday O\nbetween O\nAlmere B-LOC\nand O\nDoetinchem B-LOC\n. O\n\n1. O\nGiovanni B-PER\nLombardi I-PER\n( O\nItaly B-LOC\n) O\nPolti B-ORG\n2 O\nhours O\n35 O\nminutes O\n\n29 O\nseconds O\n\n2. O\nRolf B-PER\nSorensen I-PER\n( O\nDenmark B-LOC\n) O\nRabobank B-ORG\n\n3. O\nLance B-PER\nArmstrong I-PER\n( O\nU.S. B-LOC\n) O\nMotorola B-ORG\n\n4. O\nMaarten B-PER\nden I-PER\nBakker I-PER\n( O\nNetherlands B-LOC\n) O\nTVM B-ORG\nall O\nsame O\ntime O\n\n5. O\nMarco B-PER\nLietti I-PER\n( O\nItaly B-LOC\n) O\nMG-Technogym B-ORG\n1 O\nsecond O\nbehind O\n\n6. O\nHans B-PER\nde I-PER\nClerq I-PER\n( O\nBelgium B-LOC\n) O\nPalmans B-ORG\n27 O\nseconds O\n\n7. O\nMarty B-PER\nJemison I-PER\n( O\nU.S. B-LOC\n) O\nU.S. B-ORG\nPostal I-ORG\n\n8. O\nServais B-PER\nKnaven I-PER\n( O\nNetherlands B-LOC\n) O\nTVM B-ORG\n\n9. O\nOlaf B-PER\nLudwig I-PER\n( O\nGermany B-LOC\n) O\nTelekom B-ORG\nall O\nsame O\ntime O\n\n10. O\nJeroen B-PER\nBlijlevens I-PER\n( O\nNetherlands B-LOC\n) O\nTVM B-ORG\n31 O\n\nLeading O\noverall O\nplacings O\nafter O\nthree O\nstages O\n: O\n\n1. O\nSorensen B-PER\n10.57:33 O\n\n2. O\nLombardi B-PER\n1 O\nsecond O\nbehind O\n\n3. O\nArmstrong B-PER\n2 O\nseconds O\n\n4. O\nDen B-PER\nBakker I-PER\n7 O\n\n5. O\nLietti B-PER\n8 O\n\n6. O\nFederico B-PER\nColonna I-PER\n( O\nItaly B-LOC\n) O\nMapei B-ORG\n27 O\n\n7. O\nMax B-PER\nvan I-PER\nHeeswijk I-PER\n( O\nNetherlands B-LOC\n) O\nMotorola B-ORG\n28 O\n\n8. O\nSven B-PER\nTeutenberg I-PER\n( O\nGermany B-LOC\n) O\nU.S. B-ORG\nPostal I-ORG\n31 O\n\n9. O\nJohan B-PER\nCapiot I-PER\n( O\nBelgium B-LOC\n) O\nCollstrop B-ORG\n32 O\n\n10. O\nJans B-PER\nKoerts I-PER\n( O\nNetherlands B-LOC\n) O\nPalmans B-ORG\n34 O\n\nThe O\nrace O\ncontinues O\non O\nThursday O\nafternoon O\nwith O\na O\n19.6 O\nfourth-stage O\nDoetinchem-Doetinchem B-MISC\ntime O\ntrial O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLAND B-LOC\nV O\nPAKISTAN B-LOC\nTOSS O\nAND O\nTEAMS O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-29 O\n\nPakistan B-LOC\nwon O\nthe O\ntoss O\nand O\nelected O\nto O\nbat O\nin O\nthe O\nfirst O\none-day O\ncricket O\ninternational O\nbetween O\nEngland B-LOC\nand O\nPakistan B-LOC\nat O\nOld B-LOC\nTrafford I-LOC\non O\nThursday O\n. O\n\nTeams O\n: O\n\nEngland B-LOC\n- O\nMike B-PER\nAtherton I-PER\n( O\ncaptain O\n) O\n, O\nNick B-PER\nKnight I-PER\n, O\nAlec B-PER\nStewart I-PER\n, O\nGraham B-PER\nThorpe I-PER\n, O\nMatthew B-PER\nMaynard I-PER\n, O\nGraham B-PER\nLloyd I-PER\n, O\nRonnie B-PER\nIrani I-PER\n, O\nRobert B-PER\nCroft I-PER\n, O\nDarren B-PER\nGough I-PER\n, O\nDean B-PER\nHeadley I-PER\n, O\nAlan B-PER\nMullally I-PER\n. O\n\nPakistan B-LOC\n: O\nAamir B-PER\nSohail I-PER\n, O\nSaeed B-PER\nAnwar I-PER\n, O\nIjaz B-PER\nAhmed I-PER\n, O\nInzamam-ul-Haq B-PER\n, O\nSalim B-PER\nMalik I-PER\n, O\nWasim B-PER\nAkram I-PER\n( O\ncaptain O\n) O\n, O\nMoin B-PER\nKhan I-PER\n, O\nMushtaq B-PER\nAhmed I-PER\n, O\nWaqar B-PER\nYounis I-PER\n, O\nAta-ur-Rehman B-PER\n, O\nSaqlain B-PER\nMushtaq I-PER\n. O\n\n-DOCSTART- O\n\nCRICKET O\n- O\nENGLISH B-MISC\nCOUNTY I-MISC\nCHAMPIONSHIP I-MISC\nSCORES O\n. O\n\nLONDON B-LOC\n1996-08-29 O\n\nClose O\nof O\nplay O\nscores O\nin O\nEnglish B-MISC\ncounty O\nchampionship O\nmatches O\non O\nThursday O\n: O\n\nTunbridge B-LOC\nWells I-LOC\n: O\nNottinghamshire B-ORG\n40-3 O\nv O\nKent B-ORG\n\nLondon B-LOC\n( O\nThe B-LOC\nOval I-LOC\n) O\n: O\nWarwickshire B-ORG\n195 O\n( O\nA. B-PER\nGiles I-PER\n50 O\n; O\nB. B-PER\nJulian I-PER\n4-66 O\n, O\nC. B-PER\nLewis I-PER\n4-45 O\n) O\n, O\nSurrey B-ORG\n82-0 O\n. O\n\nHove B-LOC\n: O\nSussex B-ORG\n285-6 O\n( O\nW. B-PER\nAthey I-PER\n111 O\n) O\nv O\nLancashire B-ORG\n\nLeeds B-ORG\n( O\nHeadingley B-LOC\n) O\n: O\nYorkshire B-ORG\n290 O\n( O\nC. B-PER\nWhite I-PER\n76 O\n, O\nM. B-PER\nMoxon I-PER\n59 O\n, O\nR. B-PER\nBlakey I-PER\n57 O\n) O\n, O\nEssex B-ORG\n79-2 O\n. O\n\nChester-le-Street B-LOC\n: O\nGlamorgan B-ORG\n259 O\n( O\nP. B-PER\nCottey I-PER\n81 O\n; O\nM. B-PER\nSaggers I-PER\n6-65 O\n) O\nand O\n8-0 O\n, O\nDurham B-ORG\n114 O\n( O\nS. B-PER\nWatkin I-PER\n4-28 O\n) O\n\nChesterfield B-LOC\n: O\nWorcestershire B-ORG\n238 O\n( O\nW. B-PER\nWeston I-PER\n100 O\nnot O\nout O\n, O\nV. B-PER\nSolanki I-PER\n58 O\n; O\nA. B-PER\nHarris I-PER\n4-31 O\n) O\n, O\nDerbyshire B-ORG\n166-1 O\n( O\nK. B-PER\nBarnett I-PER\n83 O\nnot O\nout O\n) O\n\nPortsmouth B-LOC\n: O\nMiddlesex B-ORG\n199 O\nand O\n226-1 O\n( O\nJ. B-PER\nPooley I-PER\n106 O\nnot O\nout O\n, O\nM. B-PER\nRamprakash I-PER\n81 O\nnot O\nout O\n) O\n, O\nHampshire B-ORG\n232 O\n( O\nA. B-PER\nFraser I-PER\n5-55 O\n, O\nR. B-PER\nFay I-PER\n4-77 O\n) O\n\nLeicester B-LOC\n: O\nSomerset B-ORG\n83 O\n( O\nD. B-PER\nMillns I-PER\n4-35 O\n) O\n, O\nLeicestershire B-ORG\n202-5 O\n\nBristol B-LOC\n: O\nGloucestershire B-ORG\n183 O\n( O\nJ. B-PER\nRussell I-PER\n50 O\n) O\n, O\nNorthamptonshire B-ORG\n123-4 O\n( O\nK. B-PER\nCurran I-PER\n51 O\nnot O\nout O\n) O\n. O\n\n-DOCSTART- O\n\nRUGBY B-ORG\nUNION I-ORG\n- O\nTELFER B-PER\nCONFIRMED O\nFOR O\nLIONS B-ORG\nCOACHING O\nROLE O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nScotland B-LOC\n's O\nJim B-PER\nTelfer I-PER\nwas O\nofficially O\nconfirmed O\non O\nThursday O\nas O\nassistant O\ncoach O\nfor O\nthe O\nBritish B-ORG\nLions I-ORG\ntour O\nto O\nSouth B-LOC\nAfrica I-LOC\nnext O\nyear O\n. O\n\nTelfer B-PER\n, O\nwho O\nhas O\nput O\non O\nhold O\nhis O\nrole O\nas O\nScotland B-LOC\nteam O\nmanager O\nfor O\na O\nyear O\n, O\nwill O\nact O\nas O\nassistant O\nto O\nIan B-PER\nMcGeechan I-PER\n. O\n\nThe O\npair O\nlast O\nworked O\ntogether O\nwhen O\nScotland B-LOC\nwon O\nthe O\nFive B-MISC\nNations I-MISC\ngrand O\nslam O\nin O\n1990 O\n. O\n\nThe O\ntour O\nparty O\nwill O\nbe O\nannounced O\ntowards O\nthe O\nend O\nof O\nMarch O\n. O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nCHRISTIE B-PER\nTO O\nRUN O\nIN O\nBERLIN B-LOC\n. O\n\nLONDON B-LOC\n1996-08-29 O\n\nLinford B-PER\nChristie I-PER\nhas O\nconfirmed O\nhe O\nwill O\nrun O\nin O\na O\n\" O\nDream B-ORG\nTeam I-ORG\n\" O\nsprint O\nrelay O\nat O\nthe O\nBerlin B-LOC\ngrand O\nprix O\nathletics O\nmeeting O\non O\nFriday O\n. O\n\nA O\nspokeswoman O\nfor O\nChristie B-PER\nsaid O\nthe O\nformer O\nOlympic B-MISC\n100 O\nmetres O\nchampion O\nhad O\nagreed O\nto O\ncaptain O\na O\nquality O\nquartet O\nwhich O\nalso O\nincludes O\nCanada B-LOC\n's O\nDonovan B-PER\nBailey I-PER\n, O\nthe O\ncurrent O\nOlympic B-MISC\nchampion O\nand O\nworld O\nrecord O\nholder O\n, O\nand O\nNamibian O\nFrankie B-PER\nFredericks I-PER\n. O\n\nChristie B-PER\nis O\nretiring O\nfrom O\ninternational O\ncompetition O\nat O\nthe O\nend O\nof O\nthe O\nseason O\n, O\nbut O\nBerlin B-LOC\npromoter O\nRudi B-PER\nThiel I-PER\nhas O\npersuaded O\nhim O\nto O\njoin O\nwhat O\nis O\nintended O\nto O\nbe O\na O\nspecial O\ntribute O\nto O\nJesse B-PER\nOwens I-PER\n, O\nwho O\nwon O\nfour O\ngold O\nmedals O\n60 O\nyears O\nago O\nat O\nthe O\nBerlin B-LOC\nOlympics B-MISC\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGROBBELAAR B-PER\nNAMED O\nTEMPORARY O\nZIMBABWE B-LOC\nCOACH O\n. O\n\nHARARE B-LOC\n1996-08-29 O\n\nEngland-based B-MISC\ngoalkeeper O\nBruce B-PER\nGrobbelaar I-PER\nhas O\nbeen O\nappointed O\ntemporary O\nhead O\ncoach O\nof O\nthe O\nZimbabwe B-LOC\nnational O\nsoccer O\nteam O\nfor O\ntwo O\ninternational O\nmatches O\n, O\nthe O\nZimbabwe B-ORG\nFootball I-ORG\nAssociation I-ORG\n( O\nZIFA B-ORG\n) O\nsaid O\non O\nThursday O\n. O\n\nZIFA B-ORG\nvice-chairman O\nVincent B-PER\nPamire I-PER\nsaid O\nGrobbelaar B-PER\nwould O\ntake O\ncharge O\nfor O\na O\nmatch O\nagainst O\nTanzania B-LOC\nin O\nHarare B-LOC\non O\nSeptember O\n29 O\nin O\nthe O\nfive-nation O\nCastle B-MISC\nCup I-MISC\nof I-MISC\nAfrica I-MISC\ntournament O\nand O\nan O\nAfrican B-MISC\nNations I-MISC\n' I-MISC\nCup I-MISC\nfirst O\nround O\nqualifier O\nagainst O\nSudan B-LOC\nin O\nKhartoum B-LOC\non O\nOctober O\n5 O\n. O\n\nGrobbelaar B-PER\ntakes O\nover O\nuntil O\na O\npermanent O\nreplacement O\nis O\nappointed O\nfor O\nZimbabwe B-LOC\n's O\nprevious O\ncoach O\n, O\nSwitzerland B-LOC\n's O\nMarc B-PER\nDuvillard I-PER\n. O\n\nGrobbelaar B-PER\nnow O\nplays O\nfor O\nEnglish B-MISC\nsecond O\ndivision O\nleaders O\nPlymouth B-ORG\nArgyle I-ORG\nafter O\nyears O\nin O\nthe O\ntop O\nflight O\nwith O\nLiverpool B-ORG\nand O\nSouthampton B-ORG\n. O\n\nGrobbelaar B-PER\n, O\nfellow O\ngoalkeeper O\nHans B-PER\nSegers I-PER\n, O\nretired O\nstriker O\nJohn B-PER\nFashanu I-PER\nand O\nMalaysian B-MISC\nbusinessman O\nHeng B-PER\nSuan I-PER\nLim I-PER\npleaded O\nnot O\nguilty O\nin O\nMay O\nto O\ncharges O\nof O\ngiving O\nor O\naccepting O\nbribes O\nto O\nfix O\nEnglish B-MISC\npremier O\nleague O\nmatches O\n. O\n\nThey O\nare O\ndue O\nto O\nstand O\ntrial O\nnext O\nJanuary O\n. O\n\n-DOCSTART- O\n\nBASKETBALL O\n- O\nOLYMPIAKOS B-ORG\nBEAT O\nDINAMO B-ORG\n69-60 O\n. O\n\nBELGRADE B-LOC\n1996-08-29 O\n\nOlympiakos B-ORG\nof O\nGreece B-LOC\nbeat O\nRussia B-LOC\n's O\nDinamo B-ORG\n69-60 O\n( O\nhalftime O\n35-23 O\n) O\nin O\nthe O\nthird O\nmatch O\nof O\nan O\ninternational O\nbasketball O\ntournament O\non O\nThursday O\n, O\nqualifying O\nfor O\nthe O\nfinals O\n. O\n\nPartizan B-ORG\nand O\nRed B-ORG\nStar I-ORG\nof O\nYugoslavia B-LOC\n, O\nAlba B-ORG\nof O\nGermany B-LOC\n, O\nand O\nBenetton B-ORG\nof O\nItaly B-LOC\nare O\nalso O\ntaking O\npart O\nin O\nthe O\nevent O\nwhich O\ncontinues O\nuntil O\nSaturday O\n. O\n\nAdd O\nresults O\n\nPartizan B-ORG\nbeat O\nBenetton B-ORG\n97-94 O\n( O\nhalftime O\n39-32 O\n) O\n. O\n\nFinal O\nPartizan B-ORG\nv O\nOlympiakos B-ORG\n. O\n\n-DOCSTART- O\n\nSQUASH O\n- O\nHONG B-MISC\nKONG I-MISC\nOPEN I-MISC\nSECOND O\nROUND O\nRESULTS O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-29 O\n\nSecond O\nround O\nresults O\nin O\nthe O\nHong B-MISC\nKong I-MISC\nOpen I-MISC\non O\nThursday O\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\n1 O\n- O\nJansher B-PER\nKhan I-PER\n( O\nPakistan B-LOC\n) O\nbeat O\nSimon B-PER\nFrenz I-PER\n( O\nGermany B-LOC\n) O\n15-12 O\n15-7 O\n12-15 O\n15-10 O\n\nMark B-PER\nCairns I-PER\n( O\nEngland B-LOC\n) O\nbeat O\nJoseph B-PER\nKneipp I-PER\n( O\nAustralia B-LOC\n) O\n8-15 O\n15-12 O\n15-8 O\n15-8 O\n\nAnthony B-PER\nHill I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nMir B-PER\nZaman I-PER\nGul I-PER\n( O\nPakistan B-LOC\n) O\n15-12 O\n15-11 O\n15-13 O\n\nDan B-PER\nJenson I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\n3 O\n- O\nBrett B-PER\nMartin I-PER\n( O\nAustralia B-LOC\n) O\n15-9 O\n17-14 O\n7-15 O\n9-15 O\n15-14 O\n\n4 O\n- O\nPeter B-PER\nNicol I-PER\n( O\nScotland B-LOC\n) O\nbeat O\nJonathon B-PER\nPower I-PER\n( O\nCanada B-LOC\n) O\n15-10 O\n15-9 O\n15-9 O\n\n7 O\n- O\nChris B-PER\nWalker I-PER\n( O\nEngland B-LOC\n) O\nbeat O\nAmr B-PER\nShabana I-PER\n( O\nEgypt B-LOC\n) O\n15-13 O\n15-10 O\n15-6 O\n\nDerek B-PER\nRyan I-PER\n( O\nIreland B-LOC\n) O\nbeat O\nPaul B-PER\nJohnson I-PER\n( O\nEngland B-LOC\n) O\n10-15 O\n15-5 O\n12-15 O\n15-12 O\n15-11 O\n\n2 O\n- O\nRodney B-PER\nEyles I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nZubair B-PER\nJahan I-PER\nKhan I-PER\n( O\nPakistan B-LOC\n) O\n15-10 O\n15-8 O\n9-15 O\n13-15 O\n15-4 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nRESULTS O\nOF O\nSOUTH B-MISC\nKOREAN I-MISC\nPRO-SOCCER O\nGAMES O\n. O\n\nSEOUL B-LOC\n1996-08-29 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\npro-soccer O\n\ngames O\nplayed O\non O\nWednesday O\n. O\n\nChonan B-ORG\n4 O\nAnyang B-ORG\n1 O\n( O\nhalftime O\n1-0 O\n) O\n\nSuwon B-ORG\n4 O\nPusan B-ORG\n0 O\n( O\nhalftime O\n2-0 O\n) O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nWednesday O\n( O\ntabulate O\nunder O\n- O\n\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nW O\nD O\nL O\nG O\n/ O\nF O\nG O\n/ O\nA O\nP O\n\nChonan B-ORG\n3 O\n0 O\n1 O\n13 O\n10 O\n9 O\n\nPuchon B-ORG\n2 O\n1 O\n0 O\n4 O\n0 O\n7 O\n\nSuwon B-ORG\n1 O\n3 O\n0 O\n7 O\n3 O\n6 O\n\nPohang B-ORG\n1 O\n1 O\n1 O\n8 O\n8 O\n4 O\n\nUlsan B-ORG\n1 O\n0 O\n1 O\n6 O\n6 O\n3 O\n\nAnyang B-ORG\n0 O\n3 O\n1 O\n6 O\n9 O\n3 O\n\nChonnam B-ORG\n0 O\n2 O\n1 O\n4 O\n5 O\n2 O\n\nPusan B-ORG\n0 O\n2 O\n1 O\n3 O\n7 O\n2 O\n\nChonbuk B-ORG\n0 O\n0 O\n2 O\n2 O\n5 O\n0 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nRESULTS O\nOF O\nS. B-MISC\nKOREAN I-MISC\nPRO-BASEBALL O\nGAMES O\n. O\n\nSEOUL B-LOC\n1996-08-29 O\n\nResults O\nof O\nSouth B-MISC\nKorean I-MISC\n\npro-baseball O\ngames O\nplayed O\non O\nWednesday O\n. O\n\nLG B-ORG\n5 O\nOB B-ORG\n1 O\n\nOB B-ORG\n4 O\nLG B-ORG\n3 O\n\nSsangbangwool B-ORG\n12 O\nHanwha B-ORG\n0 O\n\nHanwha B-ORG\n12 O\nSsangbangwool B-ORG\n5 O\n\nLotte B-ORG\n4 O\nHyundai B-ORG\n0 O\n\nSamsung B-ORG\n7 O\nHaitai B-ORG\n1 O\n\nNote O\n- O\nLG B-ORG\nand O\nOB B-ORG\n, O\nSsangbangwool B-ORG\nand O\nHanwha B-ORG\nplayed O\ntwo O\ngames O\n. O\n\nStandings O\nafter O\ngames O\nplayed O\non O\nWednesday O\n( O\ntabulate O\nunder O\n\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\nwinning O\npercentage O\n, O\ngames O\nbehind O\nfirst O\nplace O\n) O\n\nW O\nD O\nL O\nPCT O\nGB O\n\nHaitai B-ORG\n63 O\n2 O\n42 O\n.598 O\n- O\n\nSsangbangwool B-ORG\n59 O\n2 O\n48 O\n.500 O\n5 O\n\nHanwha B-ORG\n57 O\n1 O\n49 O\n.537 O\n6 O\n1/2 O\n\nHyundai B-ORG\n56 O\n5 O\n48 O\n.536 O\n6 O\n1/2 O\n\nSamsung B-ORG\n48 O\n5 O\n55 O\n.468 O\n14 O\n\nLotte B-ORG\n45 O\n6 O\n53 O\n.462 O\n14 O\n1/2 O\n\nLG B-ORG\n45 O\n5 O\n59 O\n.436 O\n17 O\n1/2 O\n\nOB B-ORG\n42 O\n6 O\n61 O\n.413 O\n20 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nTHURSDAY O\n'S O\nRESULTS O\nFROM O\nTHE O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nResults O\nof O\nsecond O\nround O\nmatches O\non O\nThursday O\nin O\nthe O\nU.S. B-MISC\nOpen I-MISC\nTennis I-MISC\nChampionships I-MISC\nat O\nthe O\nNational B-LOC\nTennis I-LOC\nCentre I-LOC\n( O\nprefix O\nnumber O\ndenotes O\nseeding O\n) O\n: O\n\nWomen O\n's O\nsingles O\n\nAnna B-PER\nKournikova I-PER\n( O\nRussia B-LOC\n) O\nbeat O\nNatalia B-PER\nBaudone I-PER\n( O\nItaly B-LOC\n) O\n6-3 O\n6-3 O\n\nRita B-PER\nGrande I-PER\n( O\nItaly B-LOC\n) O\nbeat O\nTina B-PER\nKrizan I-PER\n( O\nSlovenia B-LOC\n) O\n6-2 O\n6-0 O\n\nEls B-PER\nCallens I-PER\n( O\nBelgium B-LOC\n) O\nbeat O\nAnnabel B-PER\nEllwood I-PER\n( O\nAustralia B-LOC\n) O\n6-4 O\n\n1-6 O\n6-1 O\n\nElena B-PER\nLikhovtseva I-PER\n( O\nRussia B-LOC\n) O\nbeat O\nLila B-PER\nOsterloh I-PER\n( O\nU.S. B-LOC\n) O\n6-4 O\n6-2 O\n\nSandra B-PER\nDopfer I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nNanne B-PER\nDahlman I-PER\n( O\nFinland B-LOC\n) O\n2-6 O\n6-2 O\n\n6- O\n3 O\n\nMen O\n's O\nsingles O\n\n13 O\n- O\nThomas B-PER\nEnqvist I-PER\n( O\nSweden B-LOC\n) O\nbeat O\nGuillaume B-PER\nRaoux I-PER\n( O\nFrance B-LOC\n) O\n6-3 O\n\n6- O\n2 O\n6-3 O\n\nSergi B-PER\nBruguera I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nMichael B-PER\nStich I-PER\n( O\nGermany B-LOC\n) O\n6-3 O\n6-2 O\n\n6-4 O\n\nJakob B-PER\nHlasek I-PER\n( O\nSwitzerland B-LOC\n) O\nbeat O\nAlberto B-PER\nBerasategui I-PER\n( O\nSpain B-LOC\n) O\n7-6 O\n( O\n7-5 O\n) O\n7-6 O\n( O\n9-7 O\n) O\n6-0 O\n\nWomen O\n's O\nsingles O\n, O\nsecond O\nround O\n\n1 O\n- O\nSteffi B-PER\nGraf I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nKarin B-PER\nKschwendt I-PER\n( O\nAustria B-LOC\n) O\n6-2 O\n6-1 O\n\nNaoko B-PER\nKijimuta I-PER\n( O\nJapan B-LOC\n) O\nbeat O\nAlexandra B-PER\nFusai I-PER\n( O\nFrance B-LOC\n) O\n6-4 O\n7-5 O\n\nNatasha B-PER\nZvereva I-PER\n( O\nBelarus B-LOC\n) O\nbeat O\nAi B-PER\nSugiyama I-PER\n( O\nJapan B-LOC\n) O\n4-6 O\n6-4 O\n6-3 O\n\n14 O\n- O\nBarbara B-PER\nPaulus I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nElena B-PER\nWagner I-PER\n( O\nGermany B-LOC\n) O\n7-5 O\n7-6 O\n( O\n7-5 O\n) O\n\nPetra B-PER\nLangrova I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nNaoko B-PER\nSawamatsu I-PER\n( O\nJapan B-LOC\n) O\n6- O\n4 O\n3-6 O\n7-5 O\n\n17 O\n- O\nKarina B-PER\nHabsudova I-PER\n( O\nSlovakia B-LOC\n) O\nbeat O\nNathalie B-PER\nDechy I-PER\n( O\nFrance B-LOC\n) O\n6-4 O\n6-2 O\n\nWomen O\n's O\nsingles O\n, O\nsecond O\nround O\n\n7 O\n- O\nJana B-PER\nNovotna I-PER\n( O\nCzech B-LOC\nRepublic I-LOC\n) O\nbeat O\nFlorencia B-PER\nLabat I-PER\n( O\nArgentina B-LOC\n) O\n6-2 O\n4-6 O\n6-2 O\n\nMen O\n's O\nsingles O\n, O\nsecond O\nround O\n\n3 O\n- O\nThomas B-PER\nMuster I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nDirk B-PER\nDier I-PER\n( O\nGermany B-LOC\n) O\n6-3 O\n6-2 O\n6-4 O\n\nPablo B-PER\nCampana I-PER\n( O\nEcuador B-LOC\n) O\nbeat O\nMark B-PER\nKnowles I-PER\n( O\nBahamas B-LOC\n) O\n7-6 O\n( O\n7-3 O\n) O\n3 O\n- O\n6 O\n6-3 O\n6-7 O\n( O\n3-7 O\n) O\n6-3 O\n\nJason B-PER\nStoltenberg I-PER\n( O\nAustralia B-LOC\n) O\nbeat O\nKenneth B-PER\nCarlsen I-PER\n( O\nDenmark B-LOC\n) O\n6- O\n3 O\n7-6 O\n( O\n7-1 O\n) O\n6-3 O\n\nArnaud B-PER\nBoetsch I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nMagnus B-PER\nGustafsson I-PER\n( O\nSweden B-LOC\n) O\n7-6 O\n( O\n8- O\n6 O\n) O\n6-3 O\n6-1 O\n\nAdd O\nWomen O\n's O\nsingles O\n, O\nsecond O\nround O\n\n16 O\n- O\nMartina B-PER\nHingis I-PER\n( O\nSwitzerland B-LOC\n) O\nbeat O\nMiriam B-PER\nOremans I-PER\n( O\nNetherlands B-LOC\n) O\n6-4 O\n6-4 O\n\nTami B-PER\nWhitlinger I-PER\nJones I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nAmy B-PER\nFrazier I-PER\n( O\nU.S. B-LOC\n) O\n7-6 O\n( O\n7-3 O\n) O\n6-2 O\n\nJudith B-PER\nWiesner I-PER\n( O\nAustria B-LOC\n) O\nbeat O\nDebbie B-PER\nGraham I-PER\n( O\nU.S. B-LOC\n) O\n6-2 O\n7-5 O\n\nAdd O\nMen O\n's O\nsingles O\n, O\nsecond O\nround O\n\n6 O\n- O\nAndre B-PER\nAgassi I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nLeander B-PER\nPaes I-PER\n( O\nIndia B-LOC\n) O\n3-6 O\n6-4 O\n6-1 O\n6-0 O\n\nJavier B-PER\nSanchez I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nJim B-PER\nGrabb I-PER\n( O\nU.S. B-LOC\n) O\n6-2 O\n7-6 O\n( O\n7-3 O\n) O\n2-6 O\n6-3 O\n\nHernan B-PER\nGumy I-PER\n( O\nArgentina B-LOC\n) O\nbeat O\nJared B-PER\nPalmer I-PER\n( O\nU.S. B-LOC\n) O\n6-7 O\n( O\n5-7 O\n) O\n6-3 O\n7-6 O\n( O\n7-4 O\n) O\n0-6 O\n7-6 O\n( O\n7-1 O\n) O\n\n: O\n\nWomen O\n's O\nsingles O\n, O\nsecond O\nround O\n\n3 O\n- O\nArantxa B-PER\nSanchez I-PER\nVicario I-PER\n( O\nSpain B-LOC\n) O\nbeat O\nNicole B-PER\nArendt I-PER\n( O\nU.S. B-LOC\n) O\n\n6-2 O\n6-2 O\n\nMen O\n's O\nsingles O\n, O\nsecond O\nround O\n\nDavid B-PER\nWheaton I-PER\n( O\nU.S. B-LOC\n) O\nbeat O\nFrederic B-PER\nVitoux I-PER\n( O\nFrance B-LOC\n) O\n6-4 O\n6-4 O\n\n4-6 O\n7-6 O\n( O\n7-4 O\n) O\n\nJan B-PER\nSiemerink I-PER\n( O\nNetherlands B-LOC\n) O\nbeat O\nCarlos B-PER\nMoya I-PER\n( O\nSpain B-LOC\n) O\n7-6 O\n\n( O\n7-2 O\n) O\n6-4 O\n6-4 O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nSTANDINGS O\nAFTER O\nWEDNESDAY O\n'S O\nGAMES O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nMajor B-MISC\nLeague I-MISC\nBaseball I-MISC\n\nstandings O\nafter O\ngames O\nplayed O\non O\nWednesday O\n( O\ntabulate O\nunder O\nwon O\n, O\n\nlost O\n, O\nwinning O\npercentage O\nand O\ngames O\nbehind O\n) O\n: O\n\nAMERICAN B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nNEW B-ORG\nYORK I-ORG\n74 O\n58 O\n.561 O\n- O\n\nBALTIMORE B-ORG\n70 O\n62 O\n.530 O\n4 O\n\nBOSTON B-ORG\n69 O\n65 O\n.515 O\n6 O\n\nTORONTO B-ORG\n63 O\n71 O\n.470 O\n12 O\n\nDETROIT B-ORG\n47 O\n86 O\n.353 O\n27 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nCLEVELAND B-ORG\n80 O\n53 O\n.602 O\n- O\n\nCHICAGO B-ORG\n71 O\n64 O\n.526 O\n10 O\n\nMINNESOTA B-ORG\n66 O\n67 O\n.496 O\n14 O\n\nMILWAUKEE B-ORG\n64 O\n70 O\n.478 O\n16 O\n1/2 O\n\nKANSAS B-ORG\nCITY I-ORG\n61 O\n73 O\n.455 O\n19 O\n1/2 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nTEXAS B-ORG\n75 O\n58 O\n.564 O\n- O\n\nSEATTLE B-ORG\n69 O\n63 O\n.523 O\n5 O\n1/2 O\n\nOAKLAND B-ORG\n64 O\n72 O\n.471 O\n12 O\n1/2 O\n\nCALIFORNIA B-ORG\n61 O\n72 O\n.459 O\n14 O\n\nTHURSDAY O\n, O\nAUGUST O\n29TH O\nSCHEDULE O\n\nKANSAS B-ORG\nCITY I-ORG\nAT O\nDETROIT B-LOC\n\nMINNESOTA B-ORG\nAT O\nMILWAUKEE B-LOC\n\nNEW B-ORG\nYORK I-ORG\nAT O\nCALIFORNIA B-LOC\n\nBALTIMORE B-ORG\nAT O\nSEATTLE B-LOC\n\nNATIONAL B-MISC\nLEAGUE I-MISC\n\nEASTERN B-MISC\nDIVISION I-MISC\n\nW O\nL O\nPCT O\nGB O\n\nATLANTA B-ORG\n82 O\n49 O\n.626 O\n- O\n\nMONTREAL B-ORG\n71 O\n60 O\n.542 O\n11 O\n\nFLORIDA B-ORG\n63 O\n70 O\n.474 O\n20 O\n\nNEW B-ORG\nYORK I-ORG\n59 O\n74 O\n.444 O\n24 O\n\nPHILADELPHIA B-ORG\n54 O\n80 O\n.403 O\n29 O\n1/2 O\n\nCENTRAL B-MISC\nDIVISION I-MISC\n\nHOUSTON B-ORG\n72 O\n62 O\n.537 O\n- O\n\nST B-ORG\nLOUIS I-ORG\n69 O\n64 O\n.519 O\n2 O\n1/2 O\n\nCINCINNATI B-ORG\n65 O\n67 O\n.492 O\n6 O\n\nCHICAGO B-ORG\n64 O\n66 O\n.492 O\n6 O\n\nPITTSBURGH B-ORG\n56 O\n76 O\n.424 O\n15 O\n\nWESTERN B-MISC\nDIVISION I-MISC\n\nSAN B-ORG\nDIEGO I-ORG\n74 O\n60 O\n.552 O\n- O\n\nLOS B-ORG\nANGELES I-ORG\n71 O\n61 O\n.538 O\n2 O\n\nCOLORADO B-ORG\n70 O\n64 O\n.522 O\n4 O\n\nSAN B-ORG\nFRANCISCO I-ORG\n57 O\n74 O\n.435 O\n15 O\n1/2 O\n\nTHURSDAY O\n, O\nAUGUST O\n29TH O\nSCHEDULE O\n\nSAN B-ORG\nDIEGO I-ORG\nAT O\nNEW B-LOC\nYORK I-LOC\n\nCHICAGO B-ORG\nAT O\nHOUSTON B-LOC\n\nCINCINNATI B-ORG\nAT O\nCOLORADO B-LOC\n\nATLANTA B-ORG\nAT O\nPITTSBURGH B-LOC\n\nLOS B-ORG\nANGELES I-ORG\nAT O\nMONTREAL B-LOC\n\nFLORIDA B-ORG\nAT O\nST B-LOC\nLOUIS I-LOC\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nYANKEES B-ORG\nBRAWL O\nAND O\nCONTINUE O\nTO O\nSLIDE O\n. O\n\nSEATTLE B-LOC\n1996-08-29 O\n\nJay B-PER\nBuhner I-PER\nhit O\na O\nthree-run O\nhomer O\nand O\nformer O\nYankee B-MISC\nTerry B-PER\nMulholland I-PER\nallowed O\none O\nrun O\nover O\nseven O\ninnings O\nas O\nthe O\nSeattle B-ORG\nMariners I-ORG\ncompleted O\na O\nsweep O\nof O\nNew B-ORG\nYork I-ORG\nwith O\na O\n10-2 O\nvictory O\nin O\na O\ngame O\nmarred O\nby O\na O\nbench-clearing O\nbrawl O\n. O\n\nIncluding O\nthe O\nlast O\nthree O\ngames O\nof O\nlast O\nOctober O\n's O\nDivisional O\nPlayoff O\nSeries O\n, O\nthe O\nMariners B-ORG\nhave O\nbeaten O\nthe O\nYankees B-ORG\n12 O\nof O\nthe O\npast O\n15 O\nmeetings O\noverall O\nand O\n14 O\nof O\nthe O\nlast O\n16 O\nin O\nthe O\nKingdome B-LOC\n. O\n\nFive O\nplayers O\nwere O\nejected O\nafter O\nYankees B-ORG\n' O\noutfielder O\nPaul B-PER\nO'Neill I-PER\nand O\nSeattle B-ORG\ncatcher O\nJohn B-PER\nMarzano I-PER\ngot O\ninto O\na O\nfight O\nafter O\nO'Neill B-PER\nhad O\nbeen O\nbrushed O\nback O\n. O\n\nIn O\nBaltimore B-LOC\n, O\nDon B-PER\nWengert I-PER\nthrew O\na O\nnine-hitter O\nfor O\nhis O\nfirst O\nshutout O\nand O\nJose B-PER\nHerrera I-PER\nhad O\na O\ntwo-run O\ndouble O\nin O\na O\nthree-run O\nfifth O\ninning O\nas O\nthe O\nOakland B-ORG\nAthletics I-ORG\nblanked O\nthe O\nBaltimore B-ORG\nOrioles I-ORG\n3-0 O\n. O\n\nWengert B-PER\n( O\n7-9 O\n) O\n, O\nwho O\nfailed O\nto O\nrecord O\na O\nshutout O\nin O\nhis O\nprevious O\n86 O\nstarts O\nin O\neither O\nthe O\nminors O\nor O\nmajors O\n, O\ndid O\nnot O\nwalk O\na O\nbatter O\nand O\nstruck O\nout O\nthree O\nfor O\nOakland B-ORG\n. O\n\nIn O\nChicago B-LOC\n, O\nJames B-PER\nBaldwin I-PER\nscattered O\nfive O\nhits O\nover O\nseven O\nscoreless O\ninnings O\nand O\nRay B-PER\nDurham I-PER\nand O\nOzzie B-PER\nGuillen I-PER\nhad O\nRBI B-MISC\nhits O\nin O\nthe O\nsecond O\ninning O\nas O\nthe O\nChicago B-ORG\nWhite I-ORG\nSox I-ORG\nblanked O\nthe O\nMilwaukee B-ORG\nBrewers I-ORG\n2-0 O\n. O\n\nBaldwin B-PER\n( O\n10-4 O\n) O\nstruck O\nout O\nfour O\nand O\ndid O\nnot O\nwalk O\na O\nbatter O\nfor O\nChicago B-LOC\n, O\nwhich O\nwon O\nfor O\nonly O\nthe O\nfourth O\ntime O\nin O\n15 O\ngames O\n. O\n\nDave B-PER\nNilsson I-PER\nhad O\nthree O\nhits O\nfor O\nthe O\nBrewers B-ORG\n. O\n\nIn O\nKansas B-LOC\nCity I-LOC\n, O\nJose B-PER\nOfferman I-PER\n's O\nsingle O\nwith O\ntwo O\nout O\nin O\nthe O\n12th O\ninning O\nscored O\nJohnny B-PER\nDamon I-PER\nwith O\nthe O\nwinning O\nrun O\nand O\nlifted O\nthe O\nKansas B-ORG\nCity I-ORG\nRoyals I-ORG\nto O\na O\n4-3 O\nvictory O\nover O\nthe O\nTexas B-ORG\nRangers I-ORG\n. O\n\nRick B-PER\nHuisman I-PER\n( O\n1-1 O\n) O\nallowed O\none O\nhit O\nand O\na O\nwalk O\nin O\nthe O\n12th O\nto O\npost O\nhis O\nfirst O\nmajor-league O\nwin O\n. O\n\nIn O\nToronto B-LOC\n, O\nPat B-PER\nHentgen I-PER\ntossed O\na O\nfive-hitter O\nfor O\nhis O\nfifth O\nconsecutive O\ncomplete O\ngame O\nand O\nthree O\nplayers O\ndrove O\nin O\ntwo O\nruns O\napiece O\nas O\nthe O\nToronto B-ORG\nBlue I-ORG\nJays I-ORG\ndefeated O\nthe O\nMinnesota B-ORG\nTwins I-ORG\n6-1 O\nfor O\ntheir O\nninth O\nwin O\nin O\n11 O\ngames O\n. O\n\nHentgen B-PER\n( O\n17-7 O\n) O\nsurrendered O\njust O\nthree O\ndoubles O\nand O\na O\npair O\nof O\nsingles O\nin O\ntossing O\nhis O\nmajor-league O\nleading O\nninth O\ncomplete O\ngame O\n. O\n\nHe O\nwalked O\nthree O\nand O\nstruck O\nout O\nthree O\nin O\nwinning O\nfor O\nthe O\n10th O\ntime O\nin O\nhis O\nlast O\n11 O\ndecisions O\n. O\n\nIn O\nDetroit B-LOC\n, O\nOrel B-PER\nHershiser I-PER\nrecorded O\nhis O\nfourth O\nstraight O\nwin O\nand O\nAlbert B-PER\nBelle I-PER\nsnapped O\na O\nsixth-inning O\ntie O\nwith O\na O\ngrand O\nslam O\nas O\nthe O\nCleveland B-ORG\nIndians I-ORG\ncompleted O\na O\nseason O\nsweep O\nof O\nthe O\nDetroit B-ORG\nTigers I-ORG\nwith O\na O\n9-3 O\nvictory O\n. O\n\nHershiser B-PER\n( O\n14-7 O\n) O\n, O\nwho O\nallowed O\nthree O\nruns O\n, O\neight O\nhits O\nand O\none O\nwalk O\nwith O\nfive O\nstrikeouts O\nover O\nseven O\ninnings O\n, O\nimproved O\nto O\n4-0 O\nin O\nhis O\nlast O\nsix O\nstarts O\n, O\nincluding O\na O\npair O\nof O\nwins O\nover O\nDetroit B-ORG\nin O\nthe O\nlast O\n11 O\ndays O\n. O\n\nAt O\nCalifornia B-LOC\n, O\n\nIn O\nSeattle B-LOC\n, O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nMAJOR B-MISC\nLEAGUE I-MISC\nRESULTS O\nWEDNESDAY O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nResults O\nof O\nMajor B-MISC\nLeague I-MISC\n\nBaseball O\ngames O\nplayed O\non O\nWednesday O\n( O\nhome O\nteam O\nin O\nCAPS O\n) O\n: O\n\nNational B-MISC\nLeague I-MISC\n\nCOLORADO B-ORG\n10 O\nCincinnati B-ORG\n9 O\n\nMONTREAL B-ORG\n6 O\nLos B-ORG\nAngeles I-ORG\n5 O\n\nAtlanta B-ORG\n9 O\nPITTSBURGH B-ORG\n4 O\n\nSan B-ORG\nDiego I-ORG\n3 O\nNEW B-ORG\nYORK I-ORG\n2 O\n( O\n10 O\ninnings O\n) O\n\nHOUSTON B-ORG\n5 O\nChicago B-ORG\n4 O\n( O\n11 O\ninnings O\n) O\n\nFlorida B-ORG\n3 O\nST B-ORG\nLOUIS I-ORG\n2 O\n( O\n10 O\ninnings O\n) O\n\nSAN B-ORG\nFRANCISCO I-ORG\n7 O\nPhiladelphia B-ORG\n6 O\n\nAmerican B-MISC\nLeague I-MISC\n\nCleveland B-ORG\n9 O\nDETROIT B-ORG\n3 O\n\nCHICAGO B-ORG\n2 O\nMilwaukee B-ORG\n0 O\n\nOakland B-ORG\n3 O\nBALTIMORE B-ORG\n0 O\n\nTORONTO B-ORG\n6 O\nMinnesota B-ORG\n1 O\n\nKANSAS B-ORG\nCITY I-ORG\n4 O\nTexas B-ORG\n3 O\n( O\n12 O\ninnings O\n) O\n\nBoston B-ORG\n7 O\nCALIFORNIA B-ORG\n4 O\n\nSEATTLE B-ORG\n10 O\nNew B-ORG\nYork I-ORG\n2 O\n\n-DOCSTART- O\n\nTENNIS O\n- O\nMARTINEZ B-PER\nGETS O\nAGGRESSIVE O\nAT O\nU.S. B-MISC\nOPEN I-MISC\n. O\n\nLarry B-PER\nFine I-PER\n\nNEW B-LOC\nYORK I-LOC\n1996-08-28 O\n\nConchita B-PER\nMartinez I-PER\ndecided O\nthat O\nwhen O\nin O\nNew B-LOC\nYork I-LOC\n, O\ndo O\nas O\nthe O\nNew B-MISC\nYorkers I-MISC\ndo O\n-- O\nand O\nthe O\nSpaniard B-MISC\n's O\nnew-found O\naggressiveness O\nseems O\nto O\nhave O\nput O\nher O\nin O\nthe O\nright O\nframe O\nof O\nmind O\nfor O\nthe O\nU.S. B-MISC\nOpen I-MISC\n. O\n\nThe O\nfourth-seeded O\nSpaniard B-MISC\n, O\nwho O\nis O\ntackling O\nthe O\nworld O\nclass O\ntraffic O\nof O\nNew B-LOC\nYork I-LOC\nCity I-LOC\nas O\na O\nwarm-up O\nby O\ndriving O\nto O\nthe O\ntennis O\ncentre O\nfor O\nher O\nmatches O\n, O\nran O\nover O\nFrance B-LOC\n's O\nNathalie B-PER\nTauziat I-PER\n6-1 O\n6-3 O\non O\nWednesday O\nto O\ntake O\nher O\nplace O\nin O\nthe O\nthird O\nround O\n. O\n\n\" O\nI O\n've O\nbeen O\ntrying O\nmy O\nwhole O\ncareer O\nto O\nbe O\naggressive O\n, O\n\" O\nsaid O\nthe O\n24-year-old O\nMartinez B-PER\nafter O\ncrushing O\nTauziat B-PER\nin O\njust O\nover O\nan O\nhour O\n. O\n\n\" O\nWhat O\nI O\n'm O\ntrying O\nto O\ndo O\nis O\nbe O\naggressive O\nall O\nthe O\ntime O\n, O\nmaybe O\ngo O\nup O\nto O\nthe O\nnet O\na O\nfew O\ntimes O\nlike O\nI O\ndid O\ntonight O\n. O\n\nThat O\nwould O\nreally O\nhelp O\n. O\n\" O\n\nMartinez B-PER\n, O\nthe O\n1994 O\nWimbledon B-MISC\nchampion O\n, O\nused O\nto O\nstruggle O\nat O\nthe O\nOpen B-MISC\n, O\nbut O\nhas O\ncome O\nto O\nterms O\nwith O\nthe O\nnoise O\n, O\ncrowds O\nand O\nchaos O\n. O\n\n\" O\nThere O\nis O\na O\nlot O\nof O\nthings O\nthat O\ncan O\nhappen O\n, O\n\" O\nMartinez B-PER\nsaid O\nabout O\nher O\nearly O\ndifficulties O\nadjusting O\nto O\ntennis O\non O\nthe O\ncement O\nat O\nFlushing B-LOC\nMeadows I-LOC\n. O\n\n\" O\nLike O\ntraffic O\n. O\n\nWe O\nstay O\nin O\nManhattan B-LOC\nand O\nit O\n's O\na O\nlong O\nway O\nto O\ncome O\n. O\n\nThe O\ncrowds O\n, O\nthey O\nspeak O\nlouder O\nor O\nthey O\nmove O\n. O\n\nThat O\ndoes O\nn't O\nhappen O\nin O\nother O\nGrand B-MISC\nSlams I-MISC\n. O\n\nThat O\n's O\nwhere O\nthe O\nreal O\nchampion O\nwins O\n. O\n\nYou O\nhave O\nto O\nconcentrate O\nfor O\nthese O\ntwo O\nweeks O\n. O\n\" O\n\nIt O\ntook O\nMartinez B-PER\nfour O\nOpens O\nto O\nget O\nas O\nfar O\nas O\nthe O\nquarters O\n, O\nand O\nanother O\nfour O\nto O\nmatch O\nthat O\n. O\n\nLast O\nyear O\n, O\nMartinez B-PER\n, O\nwho O\nfinished O\n1995 O\nranked O\nsecond O\nin O\nthe O\nworld O\n, O\nreached O\nthe O\nsemifinals O\nbefore O\nbowing O\nout O\nto O\nMonica B-PER\nSeles I-PER\n. O\n\nNow O\nshe O\nfeels O\nshe O\nis O\nin O\nthe O\nswing O\nof O\nthings O\n. O\n\n\" O\nI O\nhave O\nmy O\nown O\ncar O\nnow O\nand O\nthat O\nhelps O\n, O\n\" O\nsaid O\nMartinez B-PER\n. O\n\n\" O\nSometimes O\nthe O\ntransportation O\nthey O\n( O\nthe O\ntournament O\n) O\nprovide O\ngets O\na O\nlittle O\nmessed O\nup O\n. O\n\nThis O\ntime O\nit O\ndid O\nn't O\nhappen O\n. O\n\nI O\ndo O\nthe O\ndriving O\nand O\nI O\nlove O\nit O\n. O\n\nIt O\ngets O\nmy O\nadrenalin O\ngoing O\n, O\nthose O\ntaxi O\ndrivers O\n. O\n\n\" O\nWe O\nchange O\nlanes O\nall O\nthe O\ntime O\nin O\nBarcelona B-LOC\n. O\n\nI O\n'm O\nused O\nto O\nit O\nand O\nI O\nlike O\nto O\ndrive O\nfast O\n. O\n\" O\n\n-DOCSTART- O\n\nBASEBALL O\n- O\nBRAVES B-ORG\nSIGN O\nNEAGLE B-PER\n. O\n\nATLANTA B-LOC\n1996-08-28 O\n\nThe O\ndefending O\nworld O\nchampion O\nAtlanta B-ORG\nBraves I-ORG\n, O\nwith O\nthe O\nbest O\nrecord O\nand O\nbest O\npitching O\nin O\nbaseball O\n, O\nadded O\nanother O\nweapon O\nWednesday O\n, O\nacquiring O\nDenny B-PER\nNeagle I-PER\n, O\nthe O\nwinningest O\nleft-hander O\nin O\nthe O\nNational B-MISC\nLeague I-MISC\n, O\nfrom O\nthe O\nPittsburgh B-ORG\nPirates I-ORG\n. O\n\nThe O\nPirates B-ORG\n, O\nwho O\nconceded O\nearlier O\nthis O\nweek O\nthey O\nwould O\nbe O\nforced O\nto O\ntrim O\nsalary O\nfrom O\nnext O\nseason O\n's O\npayroll O\n, O\nreceived O\nRon B-PER\nWright I-PER\n, O\na O\nfirst O\nbaseman O\nat O\nDouble-A O\nGreenville B-ORG\n; O\nCorey B-PER\nPointer I-PER\n, O\na O\npitcher O\nat O\nClass-A O\nEugene B-ORG\n, O\nand O\na O\nplayer O\nto O\nbe O\nnamed O\n. O\n\nIt O\nwas O\nanother O\nstunning O\nmid-season O\nacquisition O\nfor O\nthe O\nBraves B-ORG\n, O\nwho O\nalready O\nhave O\nan O\n11-game O\nlead O\nin O\nthe O\nNational B-MISC\nLeague I-MISC\nEastern I-MISC\nDivision I-MISC\n. O\n\nIn O\nthe O\nlast O\n15 O\ndays O\n, O\nAtlanta B-LOC\nhas O\ntraded O\nfor O\nthird O\nbaseman O\nTerry B-PER\nPendleton I-PER\n, O\nclaimed O\noutfielder O\nLuis B-PER\nPolonia I-PER\non O\nwaivers O\nand O\ncalled O\nup O\nminor-league O\nphenom O\nAndruw B-PER\nJones I-PER\n, O\nall O\nin O\npreparation O\nfor O\ntheir O\nfifth O\npost-season O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nSUMMARY O\n. O\n\nAMSTERDAM B-LOC\n1996-08-28 O\n\nSummary O\nof O\nDutch B-MISC\nfirst O\ndivision O\nsoccer O\nmatch O\nplayed O\non O\nThursday O\n: O\n\nNAC B-ORG\nBreda I-ORG\n1 O\n( O\nAbdellaoui B-PER\n20th O\npenalty O\n) O\nNEC B-ORG\nNijmegen I-ORG\n1 O\n( O\nGraef B-PER\n36th O\n) O\n. O\n\nHalftime O\n1-1 O\n. O\n\nAttendance O\n10,760 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nDUTCH B-MISC\nFIRST O\nDIVISION O\nRESULTS O\n/ O\nSTANDINGS O\n. O\n\nAMSTERDAM B-LOC\n1996-08-29 O\n\nResult O\nof O\na O\nDutch B-MISC\nfirst O\n\ndivision O\nsoccer O\nmatch O\nplayed O\non O\nThursday O\n: O\n\nNAC B-ORG\nBreda I-ORG\n1 O\nNEC B-ORG\nNijmegen I-ORG\n1 O\n\nPlayed O\non O\nWednesday O\n: O\n\nVitesse B-ORG\nArnhem I-ORG\n1 O\nSparta B-ORG\nRotterdam I-ORG\n1 O\n\nUtrecht B-ORG\n0 O\nTwente B-ORG\nEnschede I-ORG\n0 O\n\nGroningen B-ORG\n1 O\nRoda B-ORG\nJC I-ORG\nKerkrade I-ORG\n1 O\n\nFeyenoord B-ORG\n2 O\nGraafschap B-ORG\nDoetinchem I-ORG\n1 O\n\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n1 O\nRKC B-ORG\nWaalwijk I-ORG\n3 O\n\nVolendam B-ORG\n1 O\nPSV B-ORG\nEindhoven I-ORG\n3 O\n\nAjax B-ORG\nAmsterdam I-ORG\n1 O\nAZ B-ORG\nAlkmaar I-ORG\n0 O\n\nPlayed O\non O\nTuesday O\n: O\n\nFortuna B-ORG\nSittard I-ORG\n2 O\nHeerenveen B-ORG\n4 O\n\nStandings O\n( O\ntabulate O\nunder O\nplayed O\n, O\nwon O\n, O\ndrawn O\n, O\nlost O\n, O\ngoals O\n\nfor O\n, O\ngoals O\nagainst O\n, O\npoints O\n) O\n: O\n\nPSV B-ORG\nEindhoven I-ORG\n3 O\n3 O\n0 O\n0 O\n11 O\n3 O\n9 O\n\nFeyenoord B-ORG\nRotterdam I-ORG\n3 O\n2 O\n1 O\n0 O\n6 O\n2 O\n7 O\n\nVitesse B-ORG\nArnhem I-ORG\n3 O\n2 O\n1 O\n0 O\n4 O\n1 O\n7 O\n\nHeerenveen B-ORG\n3 O\n2 O\n0 O\n1 O\n7 O\n5 O\n6 O\n\nAjax B-ORG\nAmsterdam I-ORG\n3 O\n2 O\n0 O\n1 O\n2 O\n2 O\n6 O\n\nTwente B-ORG\nEnschede I-ORG\n3 O\n1 O\n2 O\n0 O\n4 O\n2 O\n5 O\n\nRKC B-ORG\nWaalwijk I-ORG\n3 O\n1 O\n1 O\n1 O\n7 O\n6 O\n4 O\n\nGraafschap B-ORG\nDoetinchem I-ORG\n3 O\n1 O\n1 O\n1 O\n5 O\n5 O\n4 O\n\nNAC B-ORG\nBreda I-ORG\n3 O\n1 O\n1 O\n1 O\n2 O\n2 O\n4 O\n\nFortuna B-ORG\nSittard I-ORG\n3 O\n1 O\n1 O\n1 O\n3 O\n4 O\n4 O\n\nRoda B-ORG\nJC I-ORG\nKerkrade I-ORG\n3 O\n0 O\n3 O\n0 O\n3 O\n3 O\n3 O\n\nUtrecht B-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n3 O\n2 O\n\nSparta B-ORG\nRotterdam I-ORG\n3 O\n0 O\n2 O\n1 O\n1 O\n2 O\n2 O\n\nGroningen B-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n5 O\n2 O\n\nNEC B-ORG\nNijmegen I-ORG\n3 O\n0 O\n2 O\n1 O\n2 O\n5 O\n2 O\n\nWillem B-ORG\nII I-ORG\nTilburg I-ORG\n3 O\n0 O\n1 O\n2 O\n1 O\n4 O\n1 O\n\nAZ B-ORG\nAlkmaar I-ORG\n3 O\n0 O\n1 O\n1 O\n0 O\n3 O\n1 O\n\nVolendam B-ORG\n3 O\n0 O\n1 O\n2 O\n2 O\n7 O\n1 O\n\n-DOCSTART- O\n\nATHLETICS O\n- O\nJOHNSON B-PER\n, O\nCHRISTIE B-PER\n, O\nBAILEY B-PER\nTO O\nRUN O\nOWENS B-PER\nRELAY O\n. O\n\nAdrian B-PER\nWarner I-PER\n\nBERLIN B-LOC\n1996-08-29 O\n\nOlympic B-MISC\nchampions O\nMichael B-PER\nJohnson I-PER\nand O\nDonovan B-PER\nBailey I-PER\nand O\nformer O\nchampion O\nLinford B-PER\nChristie I-PER\nwill O\nrun O\nin O\na O\n\" O\nDream B-ORG\nTeam I-ORG\n\" O\nsprint O\nrelay O\nsquad O\nin O\nhonour O\nof O\nJesse B-PER\nOwens I-PER\non O\nFriday O\n. O\n\nJohnson B-PER\n, O\nthe O\n200 O\nmetres O\nworld O\nrecord O\nholder O\n, O\nand O\nBritain B-LOC\n's O\n1992 O\nOlympic B-MISC\n100 O\nchampion O\nChristie B-PER\nconfirmed O\non O\nThursday O\nthat O\nthey O\nwould O\njoin O\n100 O\nrecord O\nholder O\nBailey B-PER\nand O\nNamibia B-LOC\n's O\nFrankie B-PER\nFredericks I-PER\nin O\none O\nof O\nthe O\ngreatest O\n4x100 O\nsquads O\never O\nassembled O\n. O\n\nThey O\nwill O\nrun O\nagainst O\nquartets O\nfrom O\nthe O\nUnited B-LOC\nStates I-LOC\n, O\nEurope B-LOC\nand O\nAfrica B-LOC\nin O\na O\nspecial O\nrace O\nat O\nthe O\nBerlin B-LOC\nGrand B-MISC\nPrix I-MISC\nmeeting O\nto O\nmark O\nthe O\n60th O\nanniversary O\nof O\nOwens B-PER\n's O\nfour O\ngold O\nmedals O\nat O\nthe O\n1936 O\nOlympics B-MISC\nin O\nthe O\nGerman B-MISC\ncapital O\n. O\n\nChristie B-PER\nwill O\nrun O\nthe O\nanchor O\nleg O\nafter O\nCanada B-LOC\n's O\nBailey B-PER\n, O\nAmerican B-MISC\nJohnson B-PER\nand O\nOlympic B-MISC\nsilver O\nmedallist O\nFredericks B-PER\nhave O\nrun O\nthe O\nfirst O\nthree O\nstages O\nof O\nthe O\nrelay O\n. O\n\nThe O\nparticipation O\nof O\nBailey B-PER\nand O\nFredericks B-PER\nhad O\nbeen O\nknown O\nbefore O\nThursday O\n. O\n\nBut O\nChristie B-PER\ndid O\nnot O\nannounce O\nhis O\ndecision O\nto O\nrun O\nuntil O\nthe O\neve O\nof O\nthe O\nmeeting O\nwhen O\norganisers O\nalso O\nconfirmed O\nJohnson B-PER\nwould O\ntake O\npart O\n. O\n\nChristie B-PER\nis O\ndue O\nto O\nretire O\nfrom O\ninternational O\ncompetition O\nat O\nthe O\nend O\nof O\nthe O\nseason O\nalthough O\nhe O\nmay O\ncompete O\nfor O\nBritain B-LOC\nin O\nnext O\nseason O\n's O\nEuropean B-MISC\nCup I-MISC\n. O\n\nAlthough O\nChristie B-PER\n, O\nwho O\nis O\nnot O\nracing O\nthe O\nindividual O\n100 O\nmetres O\nin O\nBerlin B-LOC\n, O\ntook O\nhis O\ntime O\nto O\nagree O\nto O\nrun O\n, O\nthe O\nveteran O\nwas O\nclearly O\ndelighted O\nto O\nbe O\npart O\nof O\nthe O\ntribute O\nto O\nthe O\nblack O\nAmerican B-MISC\n. O\n\nWhen O\nfive O\nformer O\nOlympic B-MISC\n100 O\nchampions O\nfrom O\n1948 O\nto O\n1980 O\n, O\nwho O\nhave O\nbeen O\ninvited O\nto O\nwatch O\nthe O\nrace O\n, O\nturned O\nup O\nat O\na O\nnews O\nconference O\non O\nThursday O\n, O\nChristie B-PER\nwas O\nquick O\nto O\nput O\nhis O\nautograph O\nbook O\nin O\nfront O\nof O\nthe O\nthem O\n. O\n\n\" O\nI O\ndo O\nn't O\nnormally O\ndo O\nthis O\nbut O\ncan O\nyou O\nplease O\nsign O\n, O\n\" O\nhe O\nsaid O\nthrusting O\nan O\nornate O\nwhite O\nbook O\nin O\nfront O\nof O\nAmericans B-MISC\nHarrison B-PER\nDillard I-PER\n( O\n1948 O\n) O\n, O\nLindy B-PER\nRemigino I-PER\n( O\n1952 O\n) O\n, O\nJim B-PER\nHines I-PER\n( O\n1968 O\n) O\n, O\nTrinidad B-LOC\n's O\nHasely B-PER\nCrawford I-PER\n( O\n1976 O\n) O\nand O\nBritain B-LOC\n's O\nAllan B-PER\nWells I-PER\n( O\n1980 O\n) O\n. O\n\n\" O\nJesse B-PER\nOwens I-PER\ninspired O\neveryone O\nhere O\nand O\nit O\nis O\ngreat O\nto O\nhave O\na O\ntribute O\nto O\nhim O\n. O\n\" O\n\nOwens B-PER\n's O\nwidow O\nRuth B-PER\nis O\nnot O\nwell O\nenough O\nto O\nattend O\nbut O\na O\nmessage O\nfrom O\nher O\nwill O\nbe O\nread O\nout O\nby O\nthe O\nsprinter O\n's O\ngrand-daughter O\nGina B-PER\nTillman I-PER\nduring O\nthe O\nmeeting O\n\nBerlin B-LOC\norganisers O\nhoped O\nto O\nhave O\nAmerican B-MISC\n1984 O\nand O\n1988 O\nchampion O\nCarl B-PER\nLewis I-PER\nin O\nthe O\nsquad O\nbut O\nhe O\ninjured O\nhimself O\nin O\nlast O\nFriday O\n's O\nBrussels B-LOC\nmeeting O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nGENOA B-ORG\nAWARDED O\nITALIAN B-MISC\nCUP I-MISC\nWIN O\n. O\n\nMILAN B-LOC\n1996-08-29 O\n\nItalian B-MISC\nsoccer O\n's O\nsports O\njudge O\non O\nThursday O\nruled O\nthat O\nGenoa B-ORG\n, O\nbeaten O\n3-0 O\nby O\nLecce B-ORG\nin O\nthe O\nfirst O\nround O\nof O\nthe O\nItalian B-MISC\nCup I-MISC\n, O\nshould O\nbe O\nawarded O\na O\n2-0 O\nvictory O\nbecause O\ntheir O\nopponents O\nfielded O\na O\nbanned O\nplayer O\n. O\n\nThe O\nruling O\nmeant O\nthat O\nserie O\nB O\nclub O\nGenoa B-ORG\nnow O\nmeet O\nlocal O\nserie B-MISC\nA I-MISC\narch-rivals O\nSampdoria B-ORG\nin O\nthe O\nsecond O\nround O\n. O\n\nGenoa B-ORG\nappealed O\nafter O\ntheir O\ndefeat O\nlast O\nSaturday O\non O\nthe O\ngrounds O\nthat O\nLecce B-ORG\nstriker O\nJonathan B-PER\nBachini I-PER\n, O\nwho O\ncame O\non O\nin O\nthe O\n71st O\nminute O\nwith O\nhis O\nteam O\nleading O\n2-0 O\n, O\nstill O\nhad O\na O\none-match O\nsuspension O\nto O\nserve O\nfrom O\nlast O\nseason O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nNICE B-ORG\nSACK O\nCOACH O\nEMON B-PER\n. O\n\nNICE B-LOC\n, O\nFrance B-LOC\n1996-08-29 O\n\nStruggling O\nFrench B-MISC\nfirst O\ndivision O\nside O\nNice B-ORG\non O\nThursday O\nannounced O\nthey O\nwere O\nparting O\nwith O\ncoach O\nAlbert B-PER\nEmon I-PER\nafter O\na O\nstring O\nof O\npoor O\nresults O\n. O\n\nClub O\npresident O\nAndre B-PER\nBois I-PER\nsaid O\na O\nsuccessor O\nwould O\nbe O\nnamed O\non O\nFriday O\n. O\n\nA O\nformer O\nplayer O\nfor O\nMarseille B-ORG\nand O\nMonaco B-ORG\n, O\nEmon B-PER\n, O\n43 O\n, O\nhas O\ncoached O\nNice B-ORG\nsince O\n1992 O\n. O\n\nThe O\nannouncement O\ncame O\n24 O\nhours O\nafter O\nthe O\nteam O\nfrom O\nthe O\nFrench B-LOC\nRiviera I-LOC\nlost O\nat O\nhome O\nto O\nGuingamp B-ORG\n2-1 O\nin O\na O\nleague O\nmatch O\n. O\n\nNice B-ORG\nare O\n18th O\nin O\nthe O\ntable O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nTHREE O\nPULL O\nOUT O\nOF O\nDUTCH B-MISC\nSQUAD O\nFOR O\nBRAZIL B-LOC\n. O\n\nAMSTERDAM B-LOC\n1996-08-29 O\n\nThree O\nDutch B-MISC\nplayers O\nhave O\npulled O\nout O\nof O\nthe O\nsquad O\nfor O\nSaturday O\n's O\nfriendly O\ninternational O\nsoccer O\nmatch O\nagainst O\nBrazil B-LOC\nin O\nAmsterdam B-LOC\n. O\n\nAjax B-ORG\ndefender O\nJohn B-PER\nVeldman I-PER\nand O\nhis O\nteam O\nmate O\nRichard B-PER\nWitschge I-PER\nare O\ninjured O\n, O\nwhile O\nPSV B-ORG\nmidfielder O\nPhilip B-PER\nCocu I-PER\nhas O\na O\nfever O\n. O\n\nDutch B-MISC\ncoach O\nGuus B-PER\nHiddink I-PER\ncalled O\nin O\nFeyenoord B-ORG\nmidfielder O\nGiovanni B-PER\nvan I-PER\nBronckhorst I-PER\nand O\nVitesse B-ORG\ndefender O\nFerdy B-PER\nVierklau I-PER\nfor O\nCocu B-PER\nand O\nVeldman B-PER\n, O\nbut O\ndid O\nnot O\nname O\na O\nreplacement O\nfor O\nmidfielder O\nWitschge B-PER\n. O\n\n-DOCSTART- O\n\nBRITAIN B-LOC\nWELCOMES O\nROMANIA-HUNGARY B-MISC\nTREATY O\nACCORD O\n. O\n\nBUCHAREST B-LOC\n1996-08-29 O\n\nBritain B-LOC\njoined O\nthe O\nUnited B-LOC\nStates I-LOC\non O\nThursday O\nin O\nwelcoming O\nRomania B-LOC\nand O\nHungary B-LOC\n's O\nagreement O\non O\nthe O\ntext O\nof O\na O\nmuch-delayed O\nfriendship O\ntreaty O\n, O\nwhich O\nit O\nsaid O\nwould O\ncontribute O\nto O\nstability O\nin O\nthe O\narea O\n. O\n\n\" O\nThe O\nUnited B-LOC\nKingdom I-LOC\nbelieves O\nthat O\nsuch O\na O\ntreaty O\nwill O\ncontribute O\npositively O\nto O\nthe O\nfurther O\ndevelopment O\nof O\ngood O\nneighbourly O\nrelations O\nbetween O\nthe O\ntwo O\ncountries O\nand O\nenhance O\nthe O\nstability O\nof O\nthe O\nregion O\n, O\n\" O\nsaid O\nthe O\nBritish B-MISC\nForeign O\noffice O\nstatement O\n. O\n\nThe O\naccord O\n, O\nagreed O\ntwo O\nweeks O\nago O\n, O\nis O\nexpected O\nto O\nend O\nyears O\nof O\ndisputes O\nover O\nthe O\nstatus O\nof O\nRomania B-LOC\n's O\nlarge O\nethnic O\nHungarian B-MISC\nminority O\n. O\n\nIt O\nwill O\nalso O\nboost O\nboth O\ncountries O\n' O\nambitions O\nto O\njoin O\nNATO B-ORG\nand O\nthe O\nEuropean B-ORG\nUnion I-ORG\n. O\n\nBucharest B-LOC\nand O\nBudapest B-LOC\nsay O\nthe O\ntreaty O\nshould O\nbe O\nsigned O\nin O\nthe O\nfirst O\nhalf O\nof O\nSeptember O\n. O\n\n\" O\nThe O\nUnited B-LOC\nKingdom I-LOC\nlooks O\nforward O\nto O\nthe O\nearly O\nsignature O\nof O\nthe O\ntreaty O\n, O\n\" O\nthe O\nstatement O\nsaid O\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nEMBASSY B-MISC\nIN O\nATHENS B-LOC\nCLOSED O\nON O\nLABOUR B-MISC\nDAY I-MISC\n, O\nSEP O\n2 O\n. O\n\nATHENS B-LOC\n1996-08-29 O\n\nThe O\nU.S. B-LOC\nembassy O\nin O\nAthens B-LOC\n, O\nthe O\nconsulates O\ngeneral O\nin O\nAthens B-LOC\nand O\nThessaloniki B-LOC\nand O\nall O\nU.S. B-LOC\ngovernment O\noffices O\nin O\nGreece B-LOC\nwill O\nbe O\nclosed O\non O\nMonday O\n, O\nSeptember O\n2 O\nin O\nobservance O\nof O\nLabour B-MISC\nDay I-MISC\n, O\na O\nU.S. B-LOC\nnational O\nholiday O\n, O\nthe O\nembassy O\nsaid O\n. O\n\n-- O\nGeorge B-PER\nGeorgiopoulos I-PER\n, O\nAthens B-ORG\nNewsroom I-ORG\n+301 O\n3311812-4 O\n\n-DOCSTART- O\n\nND B-ORG\nPARTY O\nPICKS O\nSPOT B-PER\nTHOMSON I-PER\n, O\nBOLD B-ORG\n/ I-ORG\nOGILVY I-ORG\n, I-ORG\nMATHER I-ORG\nFOR O\nAD B-ORG\nCAMPAIGN O\n. O\n\nATHENS B-LOC\n1996-08-29 O\n\nGreek B-MISC\nconservative O\nNew B-ORG\ndemocracy I-ORG\nparty O\npicked O\nBold B-ORG\n/ I-ORG\nOgilvy I-ORG\nand I-ORG\nMather I-ORG\nadvertising O\ncompanies O\nfor O\nits O\npre-election O\ncampaign O\nand O\nSpot B-PER\nThomson I-PER\nto O\nhelp O\nparty O\npresident O\nMiltiadis B-PER\nEvert I-PER\non O\ncommunication O\nstrategy O\n, O\nit O\nsaid O\nin O\na O\nstatement O\n. O\n\nSpot B-PER\nThomson I-PER\nwill O\nalso O\nbe O\nresponsible O\nfor O\nthe O\ncampaign O\nTV O\nand O\nradio O\nspots O\n, O\nit O\nsaid O\n. O\n\n-- O\nDimitris B-PER\nKontogiannis I-PER\n, O\nAthens B-ORG\nNewsroom I-ORG\n+301 O\n3311812-4 O\n\n-DOCSTART- O\n\nRugby O\nstar O\nonce O\nlinked O\nto O\nPrincess O\nDiana B-PER\ndivorces O\n. O\n\nLONDON B-LOC\n1996-08-29 O\n\nFormer O\nEngland B-LOC\nrugby O\ncaptain O\nWill B-PER\nCarling I-PER\n, O\nwhose O\nmarriage O\nbroke O\ndown O\nafter O\nhe O\nwas O\nromantically O\nlinked O\nto O\nPrincess O\nDiana B-PER\n, O\nwas O\ndivorced O\nby O\nhis O\nwife O\non O\nThursday O\n, O\njust O\n24 O\nhours O\nafter O\nDiana B-PER\nand O\nPrince B-PER\nCharles I-PER\ndivorced O\n. O\n\nThe B-ORG\nTimes I-ORG\nnewspaper O\nsaid O\nDiana B-PER\nwas O\nnot O\nnamed O\nin O\nthe O\ndivorce O\npetition O\nheard O\nby O\na O\ncourt O\nin O\nSurrey B-LOC\n, O\nsouthern O\nEngland B-LOC\n. O\n\nBut O\nJulia B-PER\nCarling I-PER\n, O\na O\ntelevision O\npresenter O\n, O\nis O\nsaid O\nto O\nhave O\nblamed O\nDiana B-PER\nfor O\nthe O\nproblems O\nin O\nher O\nmarriage O\nand O\nshe O\nhas O\nrepeatedly O\nmocked O\nthe O\nprincess O\non O\nher O\nbreakfast O\ntelevision O\nprogramme O\n. O\n\nDiana B-PER\nmet O\nWill B-PER\nCarling I-PER\nat O\nan O\nexclusive O\ngymnasium O\nin O\nLondon B-LOC\n. O\n\nHe O\nhas O\nalways O\ninsisted O\nthat O\nthey O\nwere O\njust O\nfriends O\n. O\n\n-DOCSTART- O\n\nLondon B-LOC\nLIFFE B-ORG\nfutures O\nAPT O\nclosing O\nprices O\n. O\n\nLONDON B-LOC\n1996-08-29 O\n\nLondon B-ORG\nInternational I-ORG\nFinancial I-ORG\nFutures I-ORG\nExchange I-ORG\nautomated O\npit O\ntrading O\n( O\nAPT O\n) O\ntabular O\ndetails O\n: O\n\nCONTRACT O\n( O\nMONTH O\n) O\nAPT O\nCLOSE O\nSETTLEMENT O\nPREVIOUS O\nSETTLE O\n\nLONG O\nGILT O\n( O\nSEP O\n) O\n( O\n1/32 O\n) O\n107-12 O\n107-10 O\n107-06 O\n\nSHORT O\nSTERLING O\n( O\nSEP O\n) O\n94.26 O\n94.26 O\n94.26 O\n\nGERMAN B-MISC\nGOVT O\nBOND O\n( O\nSEP O\n) O\n97.42 O\n97.38 O\n97.34 O\n\nEUROMARK B-MISC\n( O\nSEP O\n) O\n96.84 O\n96.83 O\n96.83 O\n\nITALIAN B-MISC\nGOVT O\nBOND O\n( O\nSEP O\n) O\n115.62 O\n115.58 O\n115.32 O\n\nEUROLIRA B-ORG\n( O\nSEP O\n) O\n91.37 O\n91.36 O\n91.33 O\n\nEUROSWISS B-ORG\n( O\nSEP O\n) O\n97.79 O\n97.80 O\n97.82 O\n\nFTSE B-MISC\n100 I-MISC\n( O\nSEP O\n) O\n3,894.00 O\n3,894.00 O\n3,941.50 O\n\n-DOCSTART- O\n\nZaire B-LOC\ninstalls O\nfirst O\nelection O\ndelegates O\n. O\n\nKINSHASA B-LOC\n1996-08-29 O\n\nA O\ntotal O\nof O\n116 O\ndelegates O\nto O\nZaire B-LOC\n's O\nNational B-ORG\nElection I-ORG\nCommission I-ORG\n( O\nCNE B-ORG\n) O\nwere O\nformally O\ninstalled O\non O\nThursday O\n, O\nlaunching O\nanother O\nphase O\nof O\nthe O\nCentral B-MISC\nAfrican I-MISC\nnation O\n's O\nmuch-delayed O\ndemocratic O\ntransition O\n. O\n\nThe O\n116 O\n, O\nrepresenting O\npolitical O\nparties O\nin O\nthe O\ncapital O\nKinshasa B-LOC\n, O\nwill O\nhelp O\norganise O\na O\nvoter O\ncensus O\n, O\na O\nconstitutional O\nreferendum O\nplanned O\nfor O\nJanuary O\nand O\nefforts O\nto O\nbrief O\npotential O\nvoters O\non O\nwhat O\nballoting O\ninvolves O\n. O\n\nA O\ntotal O\nof O\n9,446 O\ndelegates O\nwill O\nbe O\ndeployed O\nthroughout O\nZaire B-LOC\n's O\n11 O\nprovinces O\nfor O\nthe O\nelections O\n, O\nwhich O\nmust O\nbe O\nheld O\nby O\nJuly O\n1997 O\nunder O\nthe O\ntransitional O\nconstitution O\n. O\n\nPresidential O\n, O\nparliamentary O\nand O\nmunicipal O\nelections O\nare O\nplanned O\nfor O\nMay O\n. O\n\n\" O\nWe O\ncan O\nmeet O\nthe O\nrequired O\ndeadlines O\nfor O\norganising O\nthe O\nelections O\n. O\n\nAll O\nthat O\nis O\nneeded O\nis O\nfor O\neveryone O\nto O\nshow O\ngoodwill O\n, O\n\" O\nCommission B-ORG\nspokesman O\nYoka B-PER\nLye I-PER\nMudaba I-PER\ntold O\nreporters O\n. O\n\nDelegates O\nto O\nthe O\ncommission O\nfrom O\nthe O\nother O\n10 O\nprovinces O\nwill O\nbe O\ninstalled O\nprogressively O\nfrom O\nnext O\nweek O\nwith O\nthe O\nprovinces O\nof O\nNorth B-LOC\nand O\nSouth B-LOC\nKivu I-LOC\n, O\nManiema B-LOC\n, O\nShaba B-LOC\nand O\nBandundu B-LOC\nhaving O\npriority O\n, O\nhe O\nsaid O\n. O\n\nThe O\ninstallation O\nof O\ndelegates O\nwas O\ninitially O\nscheduled O\nfor O\nJuly O\n. O\n\nOfficials O\nsaid O\nlack O\nof O\nfunding O\nhad O\ndelayed O\nthe O\nprocess O\n. O\n\nPresident O\nMobutu B-PER\nSese I-PER\nSeko I-PER\n, O\nwho O\nseized O\npower O\nin O\na O\n1965 O\ncoup O\n, O\nintroduced O\na O\nmulti-party O\nsystem O\nin O\n1990 O\nbut O\nZaire B-LOC\n's O\ntransition O\nhas O\nlagged O\nwell O\nbehind O\nthat O\nof O\nother O\nstates O\nin O\nthe O\nregion O\n. O\n\nIn O\nthe O\npast O\n, O\nMobutu B-PER\nhas O\nbeen O\nelected O\nwithout O\nopposition O\n. O\n\n-DOCSTART- O\n\nNigeria B-LOC\nwould O\nnot O\nrefuse O\nCommonwealth B-ORG\nofficials O\n. O\n\nLAGOS B-LOC\n1996-08-29 O\n\nNigeria B-LOC\nwould O\nnot O\nobject O\nto O\na O\nvisit O\nby O\nCommonwealth B-ORG\nofficials O\nbut O\ninsists O\nits O\nsuspension O\nfrom O\nthe O\norganisation O\nbe O\nresolved O\nbefore O\nany O\nother O\nquestions O\nare O\naddressed O\n, O\nForeign O\nMinister O\nTom B-PER\nIkimi I-PER\nsaid O\non O\nThursday O\n. O\n\nIkimi B-PER\nreiterated O\nhis O\nposition O\nthat O\nthe O\nCommonwealth B-ORG\nhad O\nno O\nmandate O\nto O\nsend O\na O\nfact-finding O\nmission O\n. O\n\n\" O\nThe O\nrequest O\nI O\nhave O\nreceived O\nis O\nfor O\ntheir O\nofficials O\nto O\ncome O\nand O\ntalk O\nto O\nmy O\nofficials O\n. O\n\nWe O\ncannot O\nobject O\nto O\npeople O\nwanting O\nto O\nvisit O\nNigeria B-LOC\n, O\n\" O\nIkimi B-PER\ntold O\nReuters B-ORG\nby O\ntelephone O\nfrom O\nthe O\ncapital O\nAbuja B-LOC\n. O\n\n\" O\nThe O\nfundamental O\nproblem O\nwe O\nhave O\nwith O\nthe O\nCommonwealth B-ORG\nis O\nour O\nunfair O\nsuspension O\n. O\n\nAny O\ndiscussions O\nwe O\nhave O\nat O\nministerial O\nlevel O\nwill O\nbe O\na O\ncontinuation O\nof O\nwhat O\nwe O\nbegan O\nin O\nLondon B-LOC\non O\nthat O\n. O\n\nBefore O\nthat O\nis O\naccomplished O\nwe O\ncannot O\naddress O\nanything O\nelse O\n. O\n\" O\n\nNigeria B-LOC\nwas O\nsuspended O\nfrom O\nthe O\nCommonwealth B-ORG\nin O\nNovember O\nafter O\nthe O\nexecution O\nof O\nKen B-PER\nSaro-Wiwa I-PER\nand O\neight O\nother O\nminority O\nrights O\nactivists O\nin O\ndefiance O\nof O\ninternational O\npleas O\nfor O\nclemency O\n. O\n\nA O\nmeeting O\nof O\nCommonwealth B-ORG\nministers O\nin O\nLondon B-LOC\non O\nWednesday O\nsaid O\nit O\nplanned O\nto O\nsend O\na O\nteam O\nof O\nsenior O\nofficials O\nto O\nNigeria B-LOC\nas O\nsoon O\nas O\npossible O\nto O\npersuade O\nAbuja B-LOC\nto O\naccept O\na O\nfact-finding O\nmission O\n. O\n\nThe O\ntiming O\nof O\nthat O\nmission O\nhas O\nyet O\nto O\nbe O\ndetermined O\n. O\n\nThe O\nlatest O\ndiplomatic O\nrow O\nbetween O\nNigeria B-LOC\n's O\nmilitary O\ngovernment O\nand O\nthe O\nclub O\nof O\nBritain B-LOC\nand O\nits O\nformer O\ncolonies O\nerupted O\nover O\nthe O\nterms O\nof O\na O\nvisit O\nby O\nCommonwealth B-ORG\nministers O\nto O\ndiscuss O\nNigeria B-LOC\n's O\nsuspension O\n. O\n\nNigeria B-LOC\nsaid O\nthey O\nwould O\nbe O\nrestricted O\nto O\na O\ntwo-day O\nmeeting O\nwith O\ngovernment O\nofficials O\n, O\nbut O\nthe O\nCommonwealth B-ORG\nsaid O\nit O\nwanted O\nto O\nhold O\nmeetings O\nwith O\npeople O\noutside O\nthe O\ngovernment O\nand O\ncalled O\noff O\nthe O\nvisit O\n. O\n\n-DOCSTART- O\n\nDutch B-MISC\nQueen O\nBeatrix B-PER\nto O\nvisit O\nS. B-LOC\nAfrica I-LOC\nin O\nOctober O\n. O\n\nJOHANNESBURG B-LOC\n1996-08-29 O\n\nQueen O\nBeatrix B-PER\nof O\nThe B-LOC\nNetherlands I-LOC\nwill O\npay O\na O\nfour-day O\nstate O\nvisit O\nto O\nSouth B-LOC\nAfrica I-LOC\nin O\nOctober O\n, O\nthe O\nfirst O\nby O\na O\nruling O\nDutch B-MISC\nmonarch O\n, O\nthe O\nSouth B-MISC\nAfrican I-MISC\nforeign O\nministry O\nsaid O\non O\nThursday O\n. O\n\nShe O\nwill O\nbe O\naccompanied O\nby O\nseveral O\nofficials O\nwho O\nwill O\nsign O\na O\ncultural O\nagreement O\nwith O\nSouth B-LOC\nAfrica I-LOC\n, O\nwhere O\nthe O\nDutch B-MISC\nwere O\nthe O\nfirst O\nEuropean B-MISC\nsettlers O\nin O\n1652 O\n. O\n\nThe O\nqueen O\nwill O\nbe O\naccompanied O\nby O\nher O\nhusband O\nPrince O\nClaus B-PER\non O\nthe O\nSeptember O\n30 O\nto O\nOctober O\n3 O\nvisit O\n. O\n\n-DOCSTART- O\n\nSenegal B-LOC\nbans O\nguns O\nahead O\nof O\nlocal O\nelections O\n. O\n\nDAKAR B-LOC\n1996-08-29 O\n\nWith O\ntension O\nrising O\namong O\nSenegal B-LOC\n's O\npolitical O\nparties O\nahead O\nof O\nlocal O\nelections O\non O\nNovember O\n24 O\n, O\nthe O\ninterior B-ORG\nministry I-ORG\non O\nThursday O\nbanned O\nthe O\ncarrying O\nof O\nguns O\nand O\nammunition O\nuntil O\nthe O\nend O\nof O\nthe O\nyear O\n. O\n\n\" O\nIt O\nis O\nforbidden O\nfor O\nholders O\nof O\npermits O\nfor O\nweapons O\nof O\nall O\ncategories O\nto O\ntransport O\nthe O\nsaid O\narms O\nand O\ntheir O\nammunition O\noutside O\ntheir O\nhomes O\n, O\n\" O\nthe O\nstatement O\nsaid O\n. O\n\nIt O\nsaid O\nthe O\nban O\napplied O\nto O\nSenegalese B-MISC\nnationals O\nand O\nforeign O\nresidents O\n. O\n\n-DOCSTART- O\n\nChad B-LOC\nparliamentary O\nelection O\nset O\nfor O\nNovember O\n24 O\n. O\n\nN'DJAMENA B-LOC\n1996-08-29 O\n\nChad B-LOC\n's O\nPresident O\nIdriss B-PER\nDeby I-PER\nhas O\nsigned O\na O\ndecree O\nfixing O\nNovember O\n24 O\nas O\nthe O\ndate O\nfor O\nparliamentary O\nelections O\n, O\nstate O\nradio O\nsaid O\non O\nThursday O\n. O\n\nNomads O\nwill O\nvote O\nat O\nmobile O\npolling O\nstations O\naround O\nthe O\nvast O\nCentral B-MISC\nAfrican I-MISC\ncountry O\nbetween O\nNovember O\n20 O\nand O\n24 O\n. O\n\nThe O\nelectoral O\ncommission O\nsaid O\nthe O\nnew O\n125-member O\nnational O\nassembly O\nwould O\nbe O\ninstalled O\non O\nFebruary O\n10 O\n. O\n\nDeby B-PER\ntook O\npower O\nin O\nan O\narmed O\nuprising O\nin O\n1990 O\n. O\n\nHe O\nwon O\n69 O\npercent O\nof O\nvotes O\nin O\nthe O\nsecond O\nround O\nof O\npresidential O\nelections O\non O\nJuly O\n3 O\n, O\n1996 O\n.. O\n\nHis O\nsupporters O\nwill O\ncontest O\nthe O\nparliamentary O\nelection O\nin O\na O\ncoalition O\nof O\n30 O\nmainly O\nsmall O\nparties O\n, O\nthe O\nRepublican B-ORG\nFront I-ORG\n, O\nled O\nby O\nDeby B-PER\n's O\nPatriotic B-ORG\nSalvation I-ORG\nMovement I-ORG\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nIvory B-LOC\nCoast I-LOC\n- O\nAug O\n29 O\n. O\n\nABIDJAN B-LOC\n1996-08-29 O\n\nThese O\nare O\nsignificant O\nstories O\nin O\nthe O\nIvorian B-MISC\npress O\non O\nThursday O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nFRATERNITE B-ORG\nMATIN I-ORG\n\n- O\nCabinet O\nmeeting O\nestablishes O\nfive O\nnew O\nadministrative O\nregions O\nand O\nfour O\nnew O\ndepartments O\nas O\npart O\nof O\ngovernment O\ndecentralisation O\npolicy O\n. O\n\nLA B-ORG\nVOIE I-ORG\n\n- O\nMembers O\nof O\nparliament O\nseek O\nhigher O\npay O\nand O\nmore O\nbenefits O\n. O\n\nThe O\nspeaker O\nof O\nparliament O\n, O\nCharles B-PER\nBauza I-PER\nDonwahi I-PER\n, O\nwill O\nmeet O\nPresident O\nHenri B-PER\nKonan I-PER\nBedie I-PER\non O\nSeptember O\n3 O\nto O\ndiscuss O\ntheir O\nrequest O\n. O\n\n- O\nDeputy O\ndirector O\nof O\nanimal O\nhealth O\ndepartment O\nDouati B-PER\nAlphonse I-PER\nsays O\nhis O\nagents O\nhave O\nseized O\n46 O\ntonnes O\nof O\nillicit O\npork O\nin O\na O\ntwo-week O\noperation O\nto O\nensure O\ncompliance O\nwith O\na O\nban O\nimposed O\nafter O\nan O\noutbreak O\nof O\nswine O\nfever O\n. O\n\nLE B-ORG\nJOUR I-ORG\n\n- O\nRaphael B-PER\nLakpe I-PER\n, O\npublisher O\nof O\nthe O\ndaily O\nLe B-ORG\nPopulaire I-ORG\n, O\nwas O\nreleased O\non O\nWednesday O\nevening O\nafter O\nthree O\ndays O\nin O\ncustody O\nand O\nwill O\nappear O\nin O\ncourt O\non O\nThursday O\nmorning O\n. O\n\n- O\nCabinet O\nmeeting O\nappoints O\nColonel O\nSeverin B-PER\nKonan I-PER\nKouame I-PER\nas O\ngendarmerie O\ncommander O\n, O\nreplacing O\nGeneral O\nJoseph B-PER\nTanny I-PER\n, O\nwho O\nhas O\nbeen O\nappointed O\nsecretary-general O\nof O\nthe O\nNational B-ORG\nSecurity I-ORG\nCouncil I-ORG\n. O\n\n-- O\nAbidjan B-LOC\nnewsroom O\n+225 O\n21 O\n90 O\n90 O\n\n-DOCSTART- O\n\nNATO B-ORG\nreleases O\nSerb B-MISC\npolice O\n, O\ncrisis O\neasing O\n- O\nNATO B-ORG\n. O\n\nSARAJEVO B-LOC\n1996-08-29 O\n\nNATO B-ORG\nforces O\nreleased O\na O\ngroup O\nof O\nBosnian B-MISC\nSerb I-MISC\npolicemen O\nlate O\non O\nThursday O\nand O\na O\ntense O\nconfrontation O\nappeared O\nto O\nbe O\neasing O\n, O\nan O\nalliance O\nspokesman O\nsaid O\n. O\n\n\" O\nThe O\nsituation O\nin O\nMahala B-LOC\nseems O\nto O\nbe O\nvery O\nmuch O\non O\nits O\nway O\ntoward O\nresolution O\n. O\n\nMy O\nunderstanding O\nis O\nthe O\n( O\nSerb B-MISC\n) O\npolice O\nhave O\nbeen O\nreleased O\n... O\n\nIn O\nZvornik B-LOC\n, O\nwe O\nthink O\nthe O\nsituation O\nis O\nwinding O\ndown O\nas O\nwell O\n, O\n\" O\nNATO B-ORG\nspokesman O\nLieutenant O\nColonel O\nMax B-PER\nMarriner I-PER\ntold O\nReuters B-ORG\n. O\n\nNATO B-ORG\ntroops O\ndetained O\n65 O\nBosnian B-MISC\nSerb I-MISC\npolicemen O\nearly O\non O\nThursday O\nafter O\nthey O\nattacked O\nMoslem B-MISC\nrefugees O\nreturning O\nto O\nhomes O\nin O\nMahala B-LOC\n, O\na O\nSerb-controlled B-MISC\nvillage O\non O\nBosnia B-LOC\n's O\ninternal O\nboundary O\nline O\n. O\n\nIn O\napparent O\nretaliation O\nfor O\nNATO B-ORG\n's O\ndetention O\nof O\nthe O\nSerbs B-MISC\n, O\nan O\nangry O\nSerb B-MISC\nmob O\nincluding O\npolicemen O\ntrapped O\nsix O\nunarmed O\nU.N. B-ORG\npolice O\nmonitors O\nand O\nthree O\nlocal O\naides O\nin O\ntheir O\noffice O\nin O\nthe O\ntown O\nof O\nZvornik B-LOC\n, O\neast O\nof O\nMahala B-LOC\n. O\n\nMarriner B-PER\nsaid O\nNATO B-ORG\nforces O\nconfiscated O\n25 O\nlong-barreled O\nAK-47 B-MISC\nautomatic O\nassault O\nrifles O\nfrom O\nthe O\ndetained O\nSerbs B-MISC\nbefore O\nsetting O\nthem O\nfree O\n. O\n\n\" O\nLocal O\nradio O\nand O\ntelevision O\nthere O\n( O\nin O\nZvornik B-LOC\n) O\nare O\nadvising O\npeople O\nto O\nstep O\nback O\nand O\ntake O\nit O\neasy O\n. O\n\nWe O\nthink O\nthat O\nwhen O\nthe O\nword O\nabout O\nhow O\nthings O\nare O\ngoing O\nin O\nMahala B-LOC\nwhich O\nis O\nabout O\n35 O\nminutes O\naway O\nby O\nroad O\nreaches O\nZvornik B-LOC\nthat O\nshould O\nhelp O\n, O\n\" O\nMarriner B-PER\nsaid O\n. O\n\n-DOCSTART- O\n\nStorm O\nkills O\n11 O\nat O\nMacedonian B-MISC\nreligious O\nfestival O\n. O\n\nSKOPJE B-LOC\n1996-08-29 O\n\nAt O\nleast O\n11 O\npeople O\nwere O\nkilled O\nand O\n60 O\nothers O\ninjured O\non O\nThursday O\nwhen O\nlightning O\nstruck O\na O\ngroup O\nof O\npeople O\nattending O\na O\nreligious O\nfestival O\nin O\nMacedonia B-LOC\n, O\npolice O\nand O\nmunicipal O\nofficials O\nsaid O\n. O\n\nPolice O\nin O\nBerovo B-LOC\n, O\n150 O\nkm O\n( O\n90 O\nmiles O\n) O\nwest O\nof O\nthe O\ncapital O\nSkopje B-LOC\n, O\nsaid O\nthere O\nwere O\naround O\n15,000 O\npeople O\ngathered O\naround O\nthe O\ntown O\n's O\ncathedral O\nwhen O\nthe O\nlightning O\nstruck O\nthe O\ngroup O\nduring O\na O\nthunderstorm O\n. O\n\n-DOCSTART- O\n\nKornblum B-PER\n, O\nMilosevic B-PER\ndiscuss O\nelection O\ncrisis O\n. O\n\nPeter B-PER\nGreste I-PER\n\nBELGRADE B-LOC\n1996-08-29 O\n\nU.S. B-LOC\nenvoy O\nJohn B-PER\nKornblum I-PER\nmet O\nSerbian B-MISC\nPresident O\nSlobodan B-PER\nMilosevic I-PER\non O\nThursday O\nin O\nan O\neffort O\nto O\ndefuse O\na O\ngrowing O\ncrisis O\nsurrounding O\nBosnia B-LOC\n's O\npost-war O\nelections O\n. O\n\nThe O\nAmerican B-MISC\ndiplomat O\narrived O\nin O\nBelgrade B-LOC\ntwo O\ndays O\nafter O\ninternational O\norganisers O\npostponed O\nmunicipal O\nelections O\nin O\nBosnia B-LOC\ndue O\nto O\nirregularities O\nin O\nthe O\nregistration O\nof O\nSerb B-MISC\nrefugee O\nvoters O\n. O\n\n\" O\nWe O\ndiscussed O\nthe O\ndecision O\nto O\npostpone O\nthe O\nmunicipal O\nelections O\nand O\nI O\nmade O\nclear O\nit O\nwas O\nprimarily O\nthe O\nmanipulation O\nof O\nvoter O\nregistration O\nby O\nthe O\nRepublika B-LOC\nSrpska I-LOC\n( O\nBosnian B-MISC\nSerb I-MISC\nrepublic O\n) O\nwhich O\nled O\nto O\nthis O\ndevelopment O\n, O\n\" O\nKornblum B-PER\nsaid O\nafter O\nthree O\nhours O\nof O\ntalks O\n. O\n\nBut O\nhe O\nsaid O\nthe O\nUnited B-LOC\nStates I-LOC\nstill O\nbelieved O\nit O\nwas O\nimportant O\nto O\ngo O\nahead O\nwith O\nnational O\nelections O\nin O\nBosnia B-LOC\nas O\nscheduled O\non O\nSeptember O\n14 O\nto O\nbolster O\nthe O\npeace O\nprocess O\n. O\n\nKornblum B-PER\ngave O\nno O\nindication O\nthat O\nhe O\nhad O\nwon O\nany O\nspecific O\ncommitment O\nfrom O\nMilosevic B-PER\n, O\nthe O\npatron O\nof O\nthe O\nBosnian B-MISC\nSerbs I-MISC\n, O\nto O\nrectify O\nany O\nabuses O\nin O\nthe O\nregistration O\nprocess O\n. O\n\nBosnia B-LOC\n's O\nMoslem B-MISC\npolitical O\nparties O\nhave O\nurged O\ntheir O\nrefugees O\nto O\nboycott O\nthe O\nelections O\nuntil O\nirregularities O\nwith O\nvoter O\nregistration O\nare O\nresolved O\n. O\n\nHuman O\nrights O\nworkers O\nsay O\nSerbian B-MISC\nand O\nBosnian B-MISC\nSerb I-MISC\nauthorities O\ncoerced O\nrefugees O\nto O\nregister O\nonly O\nin O\nSerb-held B-MISC\nterritory O\nin O\nBosnia B-LOC\nto O\nsolidify O\nthe O\nresults O\nof O\nwartime O\nexpulsions O\nand O\nmilitary O\nconquest O\n. O\n\nSerbian B-MISC\nofficials O\nhave O\ndenied O\nany O\nabuses O\noccurred O\nduring O\na O\n10-day O\nregistration O\nperiod O\nand O\nthe O\nBosnian B-MISC\nSerbs I-MISC\n, O\nangry O\nat O\nthe O\npostponement O\nof O\nmunicipal O\nelections O\n, O\nhave O\nthreatened O\nto O\nhold O\nlocal O\npolls O\non O\ntheir O\nterritory O\nwithout O\nthe O\ninternational O\ncommunity O\n's O\nblessing O\n. O\n\nKornblum B-PER\nsaid O\nonly O\nelections O\nendorsed O\nby O\nthe O\nOrganisation B-ORG\nfor I-ORG\nSecurity I-ORG\nand I-ORG\nCooperation I-ORG\nin I-ORG\nEurope I-ORG\n( O\nOSCE B-ORG\n) O\nwould O\nbe O\nlegitimate O\n. O\n\n\" O\nAs O\nwe O\nhave O\nsaid O\npublicly O\nbefore O\n, O\nif O\nthere O\nis O\nany O\neffort O\nto O\ndo O\nso O\n( O\nhold O\nlocal O\nelections O\n) O\nthese O\nelections O\nwill O\nnot O\nbe O\nvalid O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nThe O\nelections O\nwhich O\nare O\nvalid O\nare O\nthose O\nconducted O\nby O\nthe O\ninternational O\ncommunity O\nunder O\nthe O\nmanagement O\nof O\nthe O\nOSCE B-ORG\n. O\n\" O\n\nAfter O\nmeeting O\nMilosevic B-PER\n, O\nKornblum B-PER\nflew O\nto O\nthe O\nCroatian B-MISC\ncapital O\nZagreb B-LOC\n. O\n\nHe O\nwas O\ndue O\nto O\nhead O\nto O\nthe O\nBosnian B-MISC\ntown O\nof O\nBanja B-LOC\nLuka I-LOC\non O\nFriday O\nto O\nmeet O\nBosnian B-MISC\nSerb I-MISC\nacting O\npresident O\nBiljana B-PER\nPlavsic I-PER\nand O\nBosnian B-MISC\nSerb I-MISC\nopposition O\nleaders O\n. O\n\nHe O\nalso O\nplanned O\nto O\ntravel O\nto O\nSarajevo B-LOC\nto O\noversee O\nthe O\nformal O\ndissolution O\nof O\nthe O\nseparatist O\nCroat B-MISC\nmini-state O\nin O\nwestern O\nBosnia B-LOC\n. O\n\nU.N. B-ORG\npolice O\n, O\nrelief O\nworkers O\nand O\nNATO B-ORG\nofficers O\nhave O\nreported O\na O\nrise O\nin O\npolitical O\nviolence O\nacross O\nBosnia B-LOC\nin O\nthe O\nrun-up O\nto O\nthe O\nSeptember O\n14 O\nelections O\n. O\n\nVoters O\nwill O\nbe O\nchoosing O\na O\nthree-member O\npresidency O\nand O\na O\nparliament O\nto O\nrule O\nover O\na O\nloose O\nunion O\nof O\nBosnia B-LOC\n, O\ncomprised O\nof O\na O\nSerb B-MISC\nrepublic O\nand O\na O\nMoslem-Croat B-MISC\nfederation O\n. O\n\n-DOCSTART- O\n\nGazprom B-ORG\nrises O\nto O\n2,901.48 O\nrbls O\nat O\nauction O\n. O\n\nMOSCOW B-LOC\n1996-08-29 O\n\nA O\nstake O\nof O\n10 O\nmillion O\nshares O\nin O\nRussian B-MISC\ngas O\nmonopoly O\nRAO B-ORG\nGazprom I-ORG\nwas O\nsold O\nat O\nauction O\non O\nThursday O\nat O\nan O\naverage O\n2,901.48 O\nroubles O\na O\nshare O\n, O\nup O\nfrom O\n2,891.00 O\nroubles O\na O\nweek O\nago O\n, O\nthe O\nFederal B-ORG\nSecurities I-ORG\nCorporation I-ORG\n( O\nFFK B-ORG\n) O\nsaid O\n. O\n\nStarting O\nprice O\nat O\nthe O\nauction O\nwas O\n2,746 O\nroubles O\na O\nshare O\nand O\nthe O\n40 O\nlots O\nsold O\nfor O\nbetween O\n2,840 O\nand O\n2,998 O\nroubles O\na O\nshare O\n, O\nthe O\nFFK B-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nstake O\nrepresented O\n0.042 O\npercent O\nof O\nGazprom B-ORG\n's O\ncapital O\n. O\n\nThe O\nFFK B-ORG\nsaid O\nthat O\nsince O\nauctions O\nbegan O\n, O\n139.75 O\nmillion O\nshares O\n, O\nequivalent O\nto O\n0.59 O\npercent O\nof O\nGazprom B-ORG\n, O\nhave O\nchanged O\nhands O\n. O\n\nGazprom B-ORG\n, O\nRussia B-LOC\n's O\nbiggest O\ncompany O\nby O\nmarket O\ncapitalisation O\n, O\nhas O\nmassive O\nreserves O\nand O\npotentially O\nhuge O\nearnings O\n. O\n\nHowever O\n, O\nits O\n23.6 O\nbillion O\nshares O\nare O\nhighly O\nilliquid O\nand O\nmanagement O\npermission O\nis O\nrequired O\nto O\nsell O\nthem O\n. O\n\nGazprom B-ORG\nhas O\nrecently O\ntightened O\nthese O\nrules O\n, O\nmaking O\nit O\nharder O\nfor O\nshareholders O\nto O\nsell O\nto O\nwhoever O\nthey O\nwant O\n, O\nwhen O\nthey O\nwant O\n. O\n\nThe O\ncompany O\nhas O\norganised O\nregular O\nauctions O\nof O\nits O\nshares O\nto O\ncreate O\nan O\norderly O\nmarket O\nin O\nthe O\npaper O\n. O\n\nAt O\nthe O\nfirst O\nauction O\non O\nMarch O\n6 O\n, O\nshares O\nsold O\nfor O\nan O\naverage O\n406.6 O\nroubles O\neach O\n, O\nand O\nprices O\nhave O\nbeen O\nrising O\nsteadily O\nsince O\nthen O\n, O\nbut O\nthe O\nrise O\nin O\nprice O\nthis O\nweek O\nand O\nlast O\nwas O\nmuch O\nless O\nthan O\nin O\nprevious O\nauctions O\n. O\n\nOn O\nthe O\nRussian B-MISC\nTrading I-MISC\nSystem I-MISC\n, O\nGazprom B-ORG\nshares O\nrose O\n25 O\npercent O\non O\nThursday O\nto O\n$ O\n0.375 O\nfrom O\n$ O\n0.300 O\n, O\nafter O\nfalling O\nby O\nover O\na O\nthird O\nearlier O\nthis O\nweek O\n. O\n\n-- O\nArtyom B-PER\nDanielyan I-PER\n, O\nMoscow B-ORG\nNewsroom I-ORG\n, O\n+7095 O\n941 O\n8520 O\n\n-DOCSTART- O\n\nSerbian B-MISC\npoliceman O\nshot O\ndead O\nin O\nKosovo B-LOC\nprovince O\n. O\n\nBELGRADE B-LOC\n1996-08-29 O\n\nA O\npoliceman O\nhas O\nbeen O\nshot O\ndead O\nin O\nSerbia B-LOC\n's O\ntroubled O\nKosovo B-LOC\nprovince O\n, O\nSerbian B-MISC\npolice O\nsaid O\non O\nThursday O\n. O\n\nIt O\nwas O\nthe O\nfifth O\nattack O\non O\npolice O\nthis O\nmonth O\nin O\nthe O\nsouthern O\nprovince O\n, O\na O\nhot O\nspot O\nof O\nethnic O\ntension O\nwhere O\nthe O\nAlbanian B-MISC\nmajority O\nhave O\nboycotted O\nSerbian B-MISC\ninstitutions O\nand O\nset O\nup O\ntheir O\nown O\n, O\nwhich O\nare O\nconsidered O\nillegal O\nby O\nBelgrade B-LOC\n. O\n\nThe O\nslain O\npoliceman O\nEjup B-PER\nBajgora I-PER\n, O\n42 O\n, O\nwas O\nan O\nAlbanian B-MISC\nwho O\nhad O\nserved O\nin O\nthe O\nSerbian B-MISC\npolice O\nand O\nstate O\nsecurity O\nsince O\n1987 O\n, O\npolice O\ntold O\nthe O\nYugoslav B-MISC\nnews O\nagency O\nTanjug B-ORG\n. O\n\nHe O\nwas O\nshot O\non O\nWednesday O\nafternoon O\nas O\nhe O\nstepped O\noff O\na O\nbus O\nnear O\nhis O\nfamily O\nhome O\nin O\nthe O\nvillage O\nof O\nDonje B-LOC\nLjupce I-LOC\nin O\nthe O\nmunicipality O\nof O\nPodujevo B-LOC\n. O\n\nJust O\nhours O\nbefore O\nWednesday O\n's O\nshooting O\n, O\nthree O\nhand O\ngrenades O\nwere O\nthrown O\nat O\na O\npolice O\nstation O\nin O\nCelopek B-LOC\n. O\n\nThey O\ncaused O\ndamage O\nbut O\nno O\ncasualties O\n, O\npolice O\nsaid O\n. O\n\nThe O\nSerbian B-MISC\nauthorities O\nblame O\nAlbanian B-MISC\ndissidents O\nfor O\nthe O\nrecent O\nspate O\nof O\nattacks O\n. O\n\nNone O\nof O\nthe O\nattackers O\nhas O\nbeen O\ncaught O\n. O\n\nKosovo B-LOC\n's O\nautonomy O\nwas O\nrevoked O\nin O\n1987 O\nand O\nSerb B-MISC\npolice O\nforces O\ncracked O\ndown O\non O\nAlbanian B-MISC\nprotests O\n. O\n\nAlbanian B-MISC\nmoderates O\nwant O\nautonomy O\nrestored O\nbut O\nhardliners O\nwant O\nto O\njoin O\nup O\nwith O\nneighbouring O\nAlbania B-LOC\n. O\n\nThe O\nSerbs B-MISC\n, O\nwho O\nmake O\nup O\n10 O\npercent O\nof O\nthe O\nprovince O\n's O\n1.8 O\nmillion O\npeople O\n, O\nclaim O\nKosovo B-LOC\nas O\nthe O\ncradle O\nof O\ntheir O\nculture O\n. O\n\n-DOCSTART- O\n\nViral O\nmeningitis O\nepidemic O\nkills O\n10 O\nin O\nRomania B-LOC\n. O\n\nBUCHAREST B-LOC\n1996-08-29 O\n\nViral O\nmeningitis O\nhas O\nkilled O\n10 O\npeople O\nin O\nRomania B-LOC\n's O\ncapital O\nBucharest B-LOC\nthis O\nmonth O\nin O\nwhat O\ndoctors O\nsaid O\non O\nThursday O\nwas O\nthe O\nworst O\nepidemic O\nof O\nits O\ntype O\nin O\nthe O\ncountry O\nfor O\na O\ndecade O\n. O\n\nSome O\n170 O\nmiddle-aged O\nand O\nelderly O\npeople O\nwith O\nthe O\ndisease O\nwere O\nbeing O\ntreated O\nin O\nhospital O\n, O\ndoctors O\nsaid O\n. O\n\nDoctor O\nEmanuil B-PER\nCeausu I-PER\n, O\nhead O\nof O\nBucharest B-LOC\n's O\nVictor B-LOC\nBabes I-LOC\nhospital O\nfor O\ninfectious O\ndiseases O\n, O\nsaid O\nthe O\nepidemic O\nhad O\nbeen O\ncaused O\nby O\na O\nvirus O\nyet O\nto O\nbe O\nidentified O\n. O\n\nIllness O\nfrom O\nviral O\nmeningitis O\nlasts O\naround O\na O\nweek O\n. O\n\nIt O\naffects O\nthe O\ngastro-intestinal O\ntract O\n, O\ncausing O\nhigh O\nfever O\n, O\nheadache O\nand O\nvomiting O\n. O\n\nIn O\n1986 O\nRomania B-LOC\nsuffered O\nan O\nepidemic O\nof O\nthe O\nmore O\ndangerous O\nbacterial O\nmeningitis O\nwhich O\nhas O\nkilled O\nsome O\n15,000 O\npeople O\nin O\ncentral O\nAfrica B-LOC\nthis O\nyear O\n. O\n\n-DOCSTART- O\n\nSerbia B-LOC\n's O\nZastava B-ORG\nworkers O\nprotest O\nenters O\n9th O\nday O\n. O\n\nBELGRADE B-LOC\n1996-08-29 O\n\nWorkers O\nat O\nSerbia B-LOC\n's O\nZastava B-ORG\narms O\nfactory O\nentered O\nthe O\nninth O\nday O\nof O\ntheir O\nprotest O\nover O\nunpaid O\nwages O\non O\nThursday O\nwith O\nmanagement O\naccused O\nthem O\nof O\nrejecting O\ntalks O\n. O\n\n\" O\nThe O\nworkers O\nkeep O\non O\ngathering O\nin O\nthe O\ncentre O\nof O\nthe O\ntown O\n, O\n\" O\nthe O\nfactory O\n's O\ngeneral O\nmanager O\nVukasin B-PER\nFilipovic I-PER\ntold O\nReuters B-ORG\n. O\n\" O\n\nBut O\nthey O\ndo O\nnot O\nwant O\nto O\ntalk O\nto O\nanyone O\n. O\n\" O\n\n\" O\nThey O\nwant O\nto O\ndiscuss O\nin O\npublic O\n, O\nat O\ntheir O\nprotest O\nmeetings O\n, O\n\" O\nFilipovic B-PER\nsaid O\n. O\n\" O\n\nAnd O\nthat O\nis O\nimpossible O\n. O\n\" O\n\nThe O\nZastava B-ORG\nworks O\nin O\nthe O\ncentral O\ntown O\nof O\nKragujevac B-LOC\nis O\nthe O\nbackbone O\nof O\nSerbia B-LOC\n's O\ndefence O\nindustry O\n, O\nsupplying O\nthe O\narmy O\nwith O\na O\nwhole O\nrange O\nof O\nweapons O\n. O\n\nIts O\nworkers O\nare O\nstaging O\nprotests O\nin O\nthe O\ntown O\n's O\nmain O\nsquare O\ndemanding O\nJune O\nand O\nJuly O\nwages O\nand O\nlast O\nyear O\n's O\nholiday O\npay O\n. O\n\nOn O\nWednesday O\n, O\nthe O\nunion O\ndemanded O\nthe O\nresignation O\nof O\nthe O\nfactory O\nmanager O\n. O\n\nBut O\nFilipovic B-PER\nsaid O\nhe O\nwould O\nnot O\nquit O\nunder O\npressure O\n. O\n\" O\n\nWe O\ncan O\ntalk O\nabout O\nit O\nand O\nI O\nam O\nprepared O\nto O\ntake O\nall O\nthe O\nconsequences O\nof O\nmismanagement O\nif O\nany O\n. O\n\" O\n\n-DOCSTART- O\n\nVenezuela B-LOC\nFinMin O\nto O\nmake O\nstatement O\nmidday O\nThursday O\n. O\n\nCARACAS B-LOC\n1996-08-28 O\n\nVenezuelan B-MISC\nFinance O\nMinister O\nLuis B-PER\nRaul I-PER\nMatos I-PER\nAzocar I-PER\nwill O\nmake O\nan O\n\" O\nimportant O\nannouncement O\n\" O\non O\nThursday O\nat O\n1230 O\nlocal O\n/ O\n1630 O\nGMT B-MISC\nat O\na O\nCentral B-ORG\nBank I-ORG\npress O\nconference O\n, O\nthe O\nFinance B-ORG\nMinistry I-ORG\nsaid O\n. O\n\nThe O\npress O\nconference O\nreplaces O\nMatos B-PER\n's O\nscheduled O\nappearance O\nat O\nan O\nIMF-hosted B-MISC\nseminar O\nThursday O\non O\nVenezuela B-LOC\n's O\neconomic O\nreform O\nprogram O\n, O\nVenezuelan B-MISC\nAgenda I-MISC\n. O\n\n-- O\nCaracas B-LOC\nnewsroom O\n, O\n582 O\n834405 O\n\n-DOCSTART- O\n\nColombia B-LOC\npolice O\nfind O\nmarijuana O\non O\nship O\n. O\n\nBOGOTA B-LOC\n, O\nColombia B-LOC\n1996-08-29 O\n\nPolice O\nsaid O\nthey O\nfound O\n35 O\nmetric O\ntons O\nof O\nmarijuana O\non O\nThursday O\non O\na O\nship O\npreparing O\nto O\nset O\nsail O\nfor O\nthe O\nNetherlands B-LOC\nfrom O\nColombia B-LOC\n's O\nCaribbean B-LOC\nport O\nof O\nCartagena B-LOC\n. O\n\nThey O\nsaid O\nthe O\ndrug O\nhad O\nbeen O\npacked O\ninto O\na O\nshipping O\ncontainer O\nand O\nwas O\nsurrounded O\nby O\nground O\ncoffee O\n. O\n\nNo O\narrests O\nhad O\nbeen O\nmade O\n, O\na O\npolice O\nspokesman O\nsaid O\n. O\n\n-DOCSTART- O\n\nVenezuela B-LOC\nnon-oil O\nexports O\nrise O\n10.6 O\npct O\nin O\nJuly O\n. O\n\nCARACAS B-LOC\n1996-08-29 O\n\nVenezuela B-LOC\n's O\nnon-traditional O\nexports O\n, O\nwhich O\nexclude O\noil O\nand O\niron O\n, O\nrose O\n10.6 O\npercent O\nin O\nJuly O\nto O\nreach O\n$ O\n334 O\nmillion O\ncompared O\nto O\n$ O\n302 O\nmillion O\nin O\nJune O\n, O\naccording O\nto O\nthe O\nCentral B-ORG\nOffice I-ORG\nof I-ORG\nStatistics I-ORG\nand I-ORG\nInformation I-ORG\n( O\nOCEI B-ORG\n) O\n. O\n\n\" O\nThe O\nrise O\nwas O\ndue O\nto O\nthe O\nend O\nof O\nexchange O\ncontrols O\n, O\n\" O\nOCEI B-ORG\nsaid O\n. O\n\nForeign O\nexchange O\ncontrols O\nwere O\nremoved O\nApril O\n22 O\nas O\npart O\nof O\na O\nwider O\nIMF-sponsored B-MISC\nprogram O\n. O\n\nNevertheless O\n, O\nexports O\nover O\nthe O\nfirst O\nseven O\nmonths O\nof O\nthe O\nyear O\nwere O\n16.8 O\npercent O\nlower O\nthan O\nduring O\nthe O\nsame O\nperiod O\nlast O\nyear O\n, O\nat O\n$ O\n2.240 O\nbillion O\ncompared O\nto O\n$ O\n2.693 O\nbillion O\n. O\n\nOver O\nthe O\nseven O\nmonths O\n, O\nthe O\nprivate O\nsector O\naccounted O\nfor O\n76 O\npercent O\nof O\ntotal O\nexports O\n, O\nwith O\n\" O\ncommon O\nmetals O\n\" O\nthe O\nstrongest O\nexport O\nsector O\naccounting O\nfor O\n$ O\n951 O\nmillion O\n, O\nor O\n42.5 O\npercent O\nof O\ntotal O\nexports O\n. O\n\n\" O\nChemical O\nproducts O\n\" O\ncame O\nnext O\nwith O\na O\n13 O\npercent O\nshare O\n, O\nthen O\n\" O\ntransport O\nmaterials O\n\" O\nwith O\nnine O\npercent O\n, O\nand O\nfinally O\nfoods O\n, O\ndrinks O\nand O\ntobacco O\nwith O\n6.3 O\npercent O\n. O\n\nColombia B-LOC\nwas O\nthe O\nchief O\nmarket O\nfor O\nVenezuela B-LOC\n's O\nnon-traditional O\nexports O\nwith O\n27.4 O\npercent O\n. O\n\nThe O\nU.S. B-LOC\nfollowed O\nwith O\na O\n24.6 O\npercent O\nshare O\n. O\n\n-- O\nCaracas B-LOC\nnewsroom O\n, O\n582 O\n834405 O\nREUTER B-PER\nJPR O\n\n-DOCSTART- O\n\nBuenos B-LOC\nAires I-LOC\nfraud O\ncops O\nheld O\nin O\nextortion O\nracket O\n. O\n\nBUENOS B-LOC\nAIRES I-LOC\n, O\nArgentina B-LOC\n1996-08-29 O\n\nThirteen O\nsenior O\npolice O\nofficers O\nfrom O\nthe O\nfraud O\nsquad O\nof O\nBuenos B-LOC\nAires I-LOC\nprovince O\nhave O\nbeen O\narrested O\non O\ncharges O\nof O\nrunning O\nan O\nextortion O\nracket O\n, O\nsecurity O\nofficials O\nsaid O\non O\nThursday O\n. O\n\nThey O\nincluded O\nall O\nthe O\ntop O\nofficers O\nfrom O\nthe O\nfraud O\ndivision O\nof O\nthe O\nnorth O\nof O\nBuenos B-LOC\nAires I-LOC\nprovince O\n, O\nincluding O\nCommissioner O\nJuan B-PER\nCarlos I-PER\nLago I-PER\n. O\n\nPolice O\nwere O\nseeking O\na O\n14th O\nofficer O\n. O\n\nLa B-ORG\nNacion I-ORG\nnewspaper O\nsaid O\nthe O\nofficers O\nwere O\nsuspected O\nof O\ndemanding O\nbribes O\nof O\n$ O\n50,000 O\nto O\n$ O\n500,000 O\nfrom O\ncompanies O\nbeing O\ninvestigated O\nfor O\ntax O\nevasion O\nin O\norder O\nto O\n\" O\nlose O\n\" O\ntheir O\nfiles O\n. O\n\nThe O\ncredibility O\nof O\nthe O\nBuenos B-LOC\nAires I-LOC\nprovincial O\npolice O\n, O\nthe O\nlargest O\nforce O\nin O\nArgentina B-LOC\n, O\nhas O\nbeen O\nundermined O\nthis O\nyear O\nby O\nscandals O\nthat O\nincluded O\nthe O\nindictment O\nof O\nthree O\nofficers O\nfor O\nlinks O\nto O\nthe O\n1994 O\nbombing O\nof O\na O\nJewish B-MISC\ncommunity O\ncentre O\nand O\nthe O\narrest O\nof O\nan O\nentire O\ndrugs O\nsquad O\nfor O\ndrug O\ntrafficking O\n. O\n\nAlberto B-PER\nPiotti I-PER\n, O\nsecurity O\nchief O\nof O\nBuenos B-LOC\nAires I-LOC\nprovince O\n, O\ntold O\nlocal O\ntelevision O\nthat O\n3,600 O\ndishonest O\nofficers O\nhad O\nbeen O\npurged O\nfrom O\nthe O\nforce O\n's O\nranks O\nin O\nthe O\npast O\nfive O\nyears O\n. O\n\n\" O\nIt O\nis O\nan O\nongoing O\ntask O\n. O\n\nAnd O\nthese O\ninvestigations O\ninto O\npolice O\ncorruption O\nare O\nonly O\npossible O\nbecause O\nthere O\nare O\npeople O\nbrave O\nenough O\nto O\ndenounce O\nthem O\n, O\n\" O\nPiotti B-PER\nsaid O\n, O\npromising O\na O\nmajor O\noverhaul O\nof O\nthe O\nprovincial O\npolice O\nnext O\nmonth O\n. O\n\n-DOCSTART- O\n\nBrazil B-LOC\ngov't O\nset O\nto O\nsend O\n1997 O\nbudget O\nto O\nCongress B-ORG\n. O\n\nBRASILIA B-LOC\n1996-08-29 O\n\nBrazilian B-MISC\nPlanning O\nMinister O\nAntonio B-PER\nKandir I-PER\nwill O\nsubmit O\nto O\na O\ndraft O\ncopy O\nof O\nthe O\n1997 O\nfederal O\nbudget O\nto O\nCongress B-ORG\non O\nThursday O\n, O\na O\nministry O\nspokeswoman O\nsaid O\n. O\n\nCongress B-ORG\nis O\nconstitutionally O\nobliged O\nto O\napprove O\nthe O\nbudget O\nby O\nthe O\nend O\nof O\nyear O\nbut O\nregularly O\nfails O\nto O\nmeet O\nthat O\nrequirement O\n. O\n\n-DOCSTART- O\n\nMexico B-LOC\nsame-day O\nCetes B-MISC\nrates O\nrise O\non O\nnervousness O\n. O\n\nMEXICO B-LOC\nCITY I-LOC\n1996-08-29 O\n\nMexico B-LOC\n's O\nsame-day O\nCetes B-MISC\nrates O\nrose O\n50 O\nbasis O\npoints O\nto O\n24.25 O\npercent O\non O\nnervousness O\nover O\na O\nnew O\nround O\nof O\nattacks O\nby O\nguerrillas O\nin O\ntwo O\nsouthern O\nstates O\n, O\ndealers O\nsaid O\n. O\n\n\" O\nThere O\nare O\npeople O\nwho O\nare O\ntaking O\nadvantage O\nof O\nthe O\nnews O\nto O\nput O\npressure O\non O\nrates O\n, O\nhowever O\n, O\nthere O\nare O\nenough O\nplayers O\nwho O\nwill O\nbuy O\nand O\nthat O\nwill O\nkeep O\nrates O\nfrom O\nrising O\ntoo O\nmuch O\n, O\n\" O\nsaid O\none O\ndealer O\n. O\n\nCo-ordinated O\nguerrilla O\nattacks O\nin O\ntwo O\nsouthern O\nstates O\novernight O\nthat O\nleft O\nat O\nleast O\n13 O\npeople O\ndead O\nhave O\ncaused O\nnervousness O\nin O\nMexico B-LOC\n's O\nfinancial O\nmarkets O\n. O\n\nBank O\nnotes O\nand O\nacceptances O\n, O\nincluding O\npagares O\n, O\nrose O\n46 O\nbasis O\npoints O\nto O\n25.10 O\npercent O\n. O\n\nDealers O\nsaid O\nthat O\nthe O\nvolume O\nof O\nlonger-term O\ngovernment O\npaper O\ndeclined O\ndue O\nto O\nmarket O\nnervousness O\n. O\n\nAt O\nleast O\n13 O\npeople O\nwere O\nkilled O\nwhen O\nscores O\nof O\nmasked O\nrebels O\nstruck O\nat O\npolice O\nand O\nmilitary O\nposts O\nin O\nOaxaca B-LOC\nand O\nGuerrero B-LOC\nstates O\novernight O\nin O\nthe O\nbiggest O\nassaults O\nin O\nmore O\nthan O\ntwo O\nyears O\n, O\nofficials O\nsaid O\non O\nThursday O\n. O\n\nMaturing O\ncredits O\nare O\nseen O\nat O\n2.209 O\nbillion O\npesos O\n, O\nand O\nthere O\nis O\nan O\noversupply O\nof O\n684 O\nbillion O\npesos O\nfrom O\nthe O\nprimary O\nauction O\n. O\n\nDealers O\nestimate O\nthat O\nthe O\nshortfall O\nwill O\nincrease O\ndue O\nto O\nthe O\ninflow O\nof O\nfunds O\nbefore O\nthe O\nend O\nof O\nthe O\nmonth O\n. O\n\n--- O\nPatricia B-PER\nLezama I-PER\n, O\nMexico B-LOC\nCity I-LOC\nnewroom O\n( O\n525 O\n) O\n728 O\n9554 O\n\n-DOCSTART- O\n\nTension O\nbuilds O\nin O\nMexican B-MISC\nstate O\nahead O\nof O\nelections O\n. O\n\n[ O\nCORRECTED O\n05:53 O\nGMT B-MISC\n] O\n\nCHILPANCINGO B-LOC\n, O\nMexico B-LOC\n1996-08-28 O\n\nPre-electoral O\nbickering O\nflared O\non O\nWednesday O\nin O\nthe O\ntroubled O\nwestern O\nMexican B-MISC\nstate O\nof O\nGuerrero B-LOC\nas O\nsome O\nopposition O\npoliticians O\ndemanded O\nthe O\narmy O\npull O\nout O\nof O\nthe O\narea O\nahead O\nof O\nan O\nupcoming O\nstate O\npoll O\n. O\n\nThe O\nmayor O\nof O\nAcatepec B-LOC\n, O\na O\nsmall O\ntown O\nsome O\n310 O\nmiles O\n( O\n500 O\nkm O\n) O\nsouth O\nof O\nMexico B-LOC\nCity I-LOC\n, O\nsent O\na O\nletter O\nto O\nMexico B-LOC\n's O\nNational B-ORG\nHuman I-ORG\nRights I-ORG\nCommission I-ORG\ncomplaining O\nthe O\narmy O\n's O\nheavy O\npresence O\nin O\nthe O\ntown O\nwould O\ninterfere O\nwith O\nthe O\nOct. O\n6 O\nelection O\n. O\n\nMayor B-PER\nAntonio I-PER\nGonzalez I-PER\nGarcia I-PER\n, O\nof O\nthe O\nopposition O\nRevolutionary B-ORG\nWorkers I-ORG\n' I-ORG\nParty I-ORG\n, O\nsaid O\nin O\nWednesday O\n's O\nletter O\nthat O\narmy O\ntroops O\nrecently O\nraided O\nseveral O\nlocal O\nfarms O\n, O\nstole O\ncattle O\nand O\nraped O\nwomen O\n. O\n\nThe O\nletter O\nwas O\nsigned O\nby O\nsome O\n200 O\narea O\nresidents O\nand O\nindigenous O\nleaders O\n. O\n\nSome O\nelectoral O\nwatchdog O\ngroups O\nalso O\nsaid O\nthe O\npresence O\nof O\nthe O\narmy O\n, O\nwhich O\nhas O\nfanned O\nout O\nacross O\nthe O\nstate O\nin O\nthe O\npast O\nmonth O\nin O\nsearch O\nof O\na O\nnew O\nguerrilla O\ngroup O\n, O\nwas O\nlikely O\nto O\nintimidate O\nvoters O\nand O\nhad O\nstirred O\nup O\ntension O\nin O\nthe O\nstate O\n. O\n\nA O\nFrench B-MISC\ngroup O\nof O\nelectoral O\nobservers O\n, O\nAgir B-ORG\nEnsemble I-ORG\npour I-ORG\nles I-ORG\nDroits I-ORG\nde I-ORG\nl'Homme I-ORG\n, O\nconcluded O\nthe O\narmy O\npresence O\nexerted O\na O\nheavy O\npsychological O\npressure O\non O\nlocal O\nfarmers O\nand O\nwould O\nprevent O\na O\nfair O\nvote O\n. O\n\nUp O\nfor O\ngrabs O\nin O\nthe O\nelection O\nare O\nthe O\nstate O\nlegislature O\nand O\n75 O\ntown O\nhalls O\n. O\n\n( O\nCorrects O\nto O\nshow O\nelections O\nare O\nnot O\nfor O\ngovernor O\n) O\n. O\n\nDespite O\nthe O\ncriticism O\n, O\nacting O\nstate O\nGov O\n. O\n\nAngel B-PER\nAguirre I-PER\npledged O\nthe O\nelections O\nwill O\nbe O\nfree O\nand O\nfair O\nand O\nsaid O\nhe O\ndid O\nnot O\nexpect O\nany O\ntrouble O\nfrom O\nthe O\nelusive O\nnew O\nguerrilla O\ngroup O\n, O\nthe O\nPopular B-ORG\nRevolutionary I-ORG\nArmy I-ORG\n. O\n\n\" O\nThe O\nelectoral O\nprocess O\nhas O\nbeen O\nproceeding O\nin O\naccordance O\nwith O\nthe O\nnew O\nstate O\nelectoral O\nlaw O\n, O\n\" O\nAguirre B-PER\nsaid O\n, O\nadding O\nthat O\nthe O\npoll O\nwould O\nbe O\n\" O\nan O\nexercise O\nin O\ntrue O\ndemocracy O\n. O\n\" O\n\n-DOCSTART- O\n\nBrazil B-LOC\npolice O\narrest O\nwanted O\nItalian B-MISC\nman O\n- O\nreport O\n. O\n\nSAO B-PER\nPAULO I-PER\n, O\nBrazil B-LOC\n1996-08-28 O\n\nBrazilian B-MISC\nauthorities O\non O\nWednesday O\narrested O\na O\n47-year-old O\nItalian B-MISC\nman O\nwanted O\nin O\nItaly B-LOC\nfor O\nties O\nto O\nthe O\nleftist O\nRed B-ORG\nBrigade I-ORG\nguerrilla O\ngroup O\nof O\nthe O\n1970s O\n, O\nlocal O\ntelevision O\nsaid O\n. O\n\nTV B-ORG\nGlobo I-ORG\nsaid O\nthe O\nSupreme B-ORG\nFederal I-ORG\nTribunal I-ORG\nordered O\nthe O\narrest O\nof O\nLuciano B-PER\nPessina I-PER\n, O\na O\npolitical O\nscientist O\nwho O\nowns O\ntwo O\nRio B-LOC\nde I-LOC\nJaneiro I-LOC\nrestaurants O\n, O\nbased O\non O\nan O\nextradition O\nrequest O\nfrom O\nthe O\nItalian B-MISC\ngovernment O\n. O\n\nThe O\nreport O\n, O\nwhich O\ncould O\nnot O\nbe O\nindependently O\nverified O\non O\nWednesday O\nnight O\n, O\nsaid O\nPessina B-PER\nwas O\nsentenced O\nin O\nItaly B-LOC\nto O\neight O\nyears O\nand O\n11 O\nmonths O\nin O\nprison O\nfor O\nrobbery O\nand O\nillegal O\nweapons O\nand O\nexplosives O\npossession O\n. O\n\nGlobo B-ORG\nquoted O\nPessina B-PER\n's O\nlawyer O\nas O\nsaying O\nhe O\nhad O\nalready O\nbeen O\nimprisoned O\nin O\nItaly B-LOC\nand O\n, O\nwhen O\nfreed O\n, O\ntravelled O\nto O\nBrazil B-LOC\n. O\n\n-DOCSTART- O\n\nSeven O\nchurches O\nslam O\nBrazil B-LOC\nrural O\nviolence O\n, O\nimpunity O\n. O\n\nBRASILIA B-LOC\n1996-08-28 O\n\nSeven O\nchurches O\njoined O\nvoices O\non O\nWednesday O\nto O\ncondemn O\nthe O\n\" O\nday-to-day O\nviolence O\n\" O\nof O\nBrazil B-LOC\n's O\nrural O\nhinterland O\nand O\nthe O\ngovernment O\n's O\nfailure O\nto O\npunish O\nthose O\nresponsible O\nfor O\nmassacres O\nof O\nlandless O\npeasants O\n. O\n\n\" O\nIn O\nthe O\nname O\nof O\nJesus B-PER\n, O\nwe O\nwant O\nto O\nbring O\nyour O\nattention O\nto O\nwhat O\nis O\ngoing O\non O\nin O\nthe O\nBrazilian B-MISC\ncountryside O\n, O\n\" O\ntwo O\nchurch O\numbrella O\ngroups O\nsaid O\nin O\na O\nLetter O\nto O\nthe O\nBrazilian B-MISC\nPeople O\n. O\n\nThe O\nletter O\nfrom O\nNational B-ORG\nCouncil I-ORG\nof I-ORG\nChristian I-ORG\nChurches I-ORG\nof I-ORG\nBrazil I-ORG\nand O\nthe O\nCoordinate B-ORG\nof I-ORG\nEcumenical I-ORG\nService I-ORG\nwas O\nsent O\nto O\nPresident O\nFernando B-PER\nHenrique I-PER\nCardoso I-PER\nafter O\na O\nseminar O\non O\nendemic O\nviolence O\ngripping O\nrural O\nBrazil B-LOC\n. O\n\nThirty-six O\npeople O\nhave O\ndied O\nso O\nfar O\nthis O\nyear O\nin O\nconflicts O\nover O\nland O\nin O\nthe O\nBrazilian B-MISC\ncountryside O\n, O\nincluding O\n19 O\nlandless O\npeasants O\nmassacred O\nby O\npolice O\nin O\nApril O\nin O\nthe O\nnorthern O\nstate O\nof O\nPara B-LOC\n. O\n\n\" O\nThe O\nproblem O\nof O\nland O\nis O\none O\nof O\nthe O\nmost O\nserious O\nfacing O\nBrazil B-LOC\n, O\n\" O\nsaid O\nLucas B-PER\nMoreira I-PER\nNeves I-PER\n, O\npresident O\nof O\nthe O\nCatholic B-MISC\nchurch O\n's O\nNational B-ORG\nConference I-ORG\nof I-ORG\nBishops I-ORG\nof I-ORG\nBrazil I-ORG\n. O\n\nThe O\nletter O\nmade O\nreference O\nto O\nmassacres O\nof O\nlandless O\npeasants O\nin O\nAugust O\n1995 O\nand O\nApril O\n1996 O\n, O\nwhich O\nclaimed O\nthe O\nlives O\nof O\n27 O\nlandless O\npeasants O\n. O\n\n-DOCSTART- O\n\nThai B-MISC\nofficial O\nflees O\nHong B-LOC\nKong I-LOC\nafter O\npassport O\nscam O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-29 O\n\nA O\nThai B-MISC\nconsular O\nofficial O\nhas O\nfled O\nHong B-LOC\nKong I-LOC\nafter O\nbeing O\nquestioned O\nby O\nanti-corruption O\npolice O\nin O\nconnection O\nwith O\nsoliciting O\nbribes O\nto O\nissue O\na O\npassport O\n, O\nHong B-LOC\nKong I-LOC\ngovernment O\nradio O\nsaid O\non O\nThursday O\n. O\n\nThe O\nunnamed O\nsuspect O\nleft O\nthe O\nBritish B-MISC\ncolony O\nafter O\nbeing O\ndetained O\nand O\nthen O\nfreed O\nby O\nthe O\nIndependent B-ORG\nCommission I-ORG\nAgainst I-ORG\nCorruption I-ORG\n( O\nICAC B-ORG\n) O\n, O\nthe O\nradio O\nsaid O\n. O\n\nThe O\nman O\nwas O\nreleased O\nafter O\nhis O\narrest O\non O\nTuesday O\n, O\npending O\nfurther O\ninquiries O\n, O\nthe O\nICAC B-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nanti-graft O\nbody O\nwas O\ndiscussing O\nthe O\ncase O\nwith O\nthe O\nThai B-MISC\ngovernment O\n, O\nespecially O\nthe O\nsuspect O\n's O\nstatus O\n, O\nit O\nsaid O\n. O\n\nIt O\nis O\nnot O\nclear O\nif O\nthe O\nfugitive O\nhad O\ndiplomatic O\nstatus O\nin O\nHong B-LOC\nKong I-LOC\n, O\nand O\nofficials O\nfrom O\nthe O\nThai B-MISC\nConsulate O\nwere O\nnot O\navailable O\nfor O\ncomment O\n. O\n\nThe O\narrest O\ncame O\nafter O\nthe O\nICAC B-ORG\nreceived O\na O\ncomplaint O\nthat O\nthe O\nman O\nhad O\ndemanded O\na O\nbribe O\nof O\nHK$ B-MISC\n100,000 O\n( O\nUS$ B-MISC\n12,940 O\n) O\nto O\nissue O\na O\nThai B-MISC\npassport O\n, O\nthe O\nICAC B-ORG\nsaid O\n. O\n\nAt O\nthe O\ntime O\nof O\nhis O\narrest O\n, O\nICAC B-ORG\nofficers O\nseized O\nHK$ B-MISC\n100,000 O\n, O\nit O\nadded O\n. O\n\nThe O\nICAC B-ORG\nhas O\nkept O\na O\nclose O\neye O\non O\npassport O\nscams O\nafter O\na O\nU.S. B-LOC\nofficial O\nwas O\njailed O\nfor O\ntrafficking O\nfake O\nHonduran B-MISC\npassports O\nas O\npart O\nof O\nan O\nimmigration O\nracket O\naimed O\nat O\nChinese B-MISC\n. O\n\n-DOCSTART- O\n\nThai B-MISC\npoll O\nshows O\nmilitary O\nwants O\nPM O\nBanharn B-PER\nout O\n. O\n\nBANGKOK B-LOC\n1996-08-29 O\n\nThailand B-LOC\n's O\npowerful O\nmilitary O\nthinks O\nthe O\ngovernment O\nis O\ndishonest O\nand O\nPrime O\nMinister O\nBanharn B-PER\nSilpa-archa I-PER\n's O\nresignation O\nmight O\nsolve O\nthe O\nnation O\n's O\npolitical O\nand O\neconomic O\nwoes O\n, O\nan O\nopinion O\npoll O\nshowed O\non O\nThursday O\n. O\n\nNearly O\nhalf O\nthe O\n1,617 O\nmilitary O\npersonnel O\nsurveyed O\nin O\nthe O\nRajapat B-ORG\nInstitute I-ORG\npoll O\nsuggested O\nthat O\nBanharn B-PER\nresign O\n, O\nwhile O\nabout O\n28 O\npercent O\nthought O\nhe O\nshould O\ndissolve O\nparliament O\nand O\n24 O\npercent O\nthought O\na O\ncabinet O\nreshuffle O\ncould O\nresolve O\nthe O\ngovernment O\n's O\nproblems O\n. O\n\nBanharn B-PER\n, O\nwho O\nleads O\na O\nsix-party O\n, O\n13-month-old O\ncoalition O\ngovernment O\n, O\nfaces O\na O\nno-confidence O\ndebate O\nin O\nparliament O\nnext O\nmonth O\n. O\n\nThe O\nprime O\nminister O\n, O\nwho O\nhas O\nalready O\nlost O\none O\ncoalition O\npartner O\nthis O\nmonth O\n, O\nis O\nexpected O\nto O\nhave O\na O\ntough O\nbattle O\nin O\nthe O\ndebate O\nbecause O\nof O\ninfighting O\nin O\nhis O\nown O\nparty O\nand O\nwarnings O\nof O\nmore O\npullouts O\nby O\nother O\ncoalition O\npartners O\n. O\n\nThe O\npoll O\n, O\nconducted O\nearlier O\nthis O\nmonth O\nafter O\nBanharn B-PER\n's O\ncoalition O\ncompleted O\none O\nyear O\nin O\noffice O\n, O\nshowed O\nthe O\nmilitary O\nwould O\nprefer O\nGeneral O\nChatichai B-PER\nChoonhavan I-PER\n-- O\na O\nformer O\nprime O\nminister O\nwho O\nwas O\nousted O\nin O\na O\nmilitary O\ncoup O\nin O\nFebruary O\n1991 O\n-- O\nas O\nprime O\nminister O\n. O\n\nDefence O\nMinister O\nChavalit B-PER\nYongchaiyudh I-PER\n, O\nhead O\nof O\ncoalition O\nmember O\nthe O\nNew B-ORG\nAspiration I-ORG\nParty I-ORG\n, O\nwas O\nthe O\nsecond O\nchoice O\nfor O\nprime O\nminister O\n, O\nthe O\npoll O\nshowed O\n. O\n\nBanharn B-PER\ncame O\nin O\nlast O\non O\nthe O\nlist O\nof O\nproposed O\nleaders O\nwith O\nless O\nthan O\none O\npercent O\nof O\nthe O\nvotes O\n. O\n\nNearly O\ntwo-thirds O\nof O\nthe O\npeople O\nsurveyed O\nthought O\nthe O\ngovernment O\nwas O\ndishonest O\nand O\ninsincere O\n, O\nand O\n65 O\npercent O\nblamed O\nthe O\ngovernment O\n's O\npoor O\nperformance O\nfor O\nthe O\ncountry O\n's O\neconomic O\nslowdown O\n. O\n\nThe O\nopinion O\nof O\nthe O\nmilitary O\nin O\nThailand B-LOC\n, O\nwhich O\nhas O\nseen O\n17 O\ncoups O\nor O\nattempted O\ncoups O\nsince O\nthe O\ncountry O\nswitched O\nto O\nparliamentary O\ndemocracy O\nfrom O\nabsolute O\nmonarchy O\nin O\n1932 O\n, O\nalways O\ncarries O\nweight O\nin O\nthe O\npolitical O\nscene O\n, O\ndespite O\nofficials O\n' O\nvows O\nto O\ndistance O\nthe O\nmilitary O\nfrom O\npolitics O\n. O\n\n-DOCSTART- O\n\nHamas B-ORG\ncleric O\njailed O\nin O\nIsrael B-LOC\nhospitalised O\nbriefly O\n. O\n\nJERUSALEM B-LOC\n1996-08-29 O\n\nIsraeli B-MISC\nprison O\nofficials O\ntook O\njailed O\nIslamic B-MISC\nmilitant O\nHamas B-ORG\nfounder O\nSheikh O\nAhmed B-PER\nYassin I-PER\nto O\nhospital O\nbriefly O\non O\nThursday O\nfor O\nmedical O\ntests O\n, O\nofficials O\nsaid O\n. O\n\n\" O\nThis O\nevening O\nSheikh O\nYassin B-PER\ncompleted O\nmedical O\nchecks O\nand O\nreturned O\nto O\nRamle B-LOC\nprisons O\nauthority O\nmedical O\ncentre O\n, O\n\" O\nsaid O\na O\nspokesman O\nfor O\nIsrael B-LOC\n's O\ninternal O\nsecurity O\nministry O\n. O\n\nA O\nprison O\nofficial O\nsaid O\nYassin B-PER\nhad O\na O\nmild O\ncase O\nof O\npneumonia O\n. O\n\nThe O\n60-year-old O\nMoslem B-MISC\ncleric O\n, O\njailed O\nby O\nIsrael B-LOC\nsince O\n1989 O\n, O\nis O\nserving O\na O\nlife O\nsentence O\nfor O\nordering O\nattacks O\nby O\nHamas B-ORG\nguerrillas O\nagainst O\nIsraeli B-MISC\ntargets O\n. O\n\nThe O\nailing O\nYassin B-PER\nis O\nthe O\nspiritual O\nleader O\nof O\nthe O\nfundamentalist O\nHamas B-ORG\ngroup O\nwhich O\nhas O\nkilled O\nscores O\nof O\nIsraelis B-MISC\nin O\nsuicide O\nattacks O\naimed O\nat O\nwrecking O\nIsrael-PLO B-MISC\npeace O\ndeals O\n. O\n\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\nhas O\ndemanded O\nthat O\nIsrael B-LOC\nrelease O\nYassin B-PER\n-- O\nwho O\nis O\nconfined O\nto O\na O\nwheelchair O\n-- O\non O\nhumanitarian O\ngrounds O\n. O\n\nIsrael B-LOC\nsaid O\nlast O\nmonth O\nafter O\nit O\nrecovered O\nthe O\nbody O\nof O\na O\nsoldier O\nabducted O\nby O\nHamas B-ORG\nseven O\nyears O\nago O\nthat O\nit O\nwould O\nconsider O\nfreeing O\nYassin B-PER\n. O\n\n-DOCSTART- O\n\nMoroccan B-MISC\nKing O\nmeets O\nformer O\nIsrael B-LOC\nPM O\nPeres B-PER\n. O\n\nSKHIRAT B-LOC\n, O\nMorocco B-LOC\n1996-08-29 O\n\nKing B-PER\nHassan I-PER\nof O\nMorocco B-LOC\nmet O\nformer O\nIsraeli B-MISC\nprime O\nminister O\nShimon B-PER\nPeres I-PER\non O\nThursday O\nat O\nthe O\ncoastal O\nresort O\nof O\nSkhirat B-LOC\n, O\n20 O\nkm O\n( O\n12 O\nmiles O\n) O\nsouth O\nof O\nRabat B-LOC\n, O\nan O\nofficial O\nsource O\nsaid O\n. O\n\n\" O\nMr O\nShimon B-PER\nPeres I-PER\n, O\nwho O\nis O\non O\na O\npurely O\nprivate O\nand O\nfamily O\nvisit O\nto O\nMorocco B-LOC\n, O\nwas O\nreceived O\non O\nThursday O\nby O\nhis O\nMajesty O\nKing B-PER\nHassan I-PER\nat O\nthe O\nroyal O\npalace O\nof O\nSkhirat B-LOC\n, O\n\" O\nthe O\nsource O\nsaid O\n. O\n\nAccompanied O\nby O\nhis O\nwife O\nand O\ngrandson O\n, O\nPeres B-PER\narrived O\nin O\nMorocco B-LOC\non O\nAugust O\n25 O\n. O\n\nPeres B-PER\nis O\nexpected O\nto O\nfly O\nhome O\non O\nFriday O\n, O\nofficials O\nsaid O\n. O\n\n-DOCSTART- O\n\nScandal O\nhits O\nClinton B-PER\ncampaign O\nat O\nvital O\nmoment O\n. O\n\nMichael B-PER\nConlon I-PER\n\nCHICAGO B-LOC\n1996-08-29 O\n\nPresident O\nBill B-PER\nClinton I-PER\n's O\ntriumphal O\nappearance O\nat O\nthe O\nDemocratic B-MISC\nconvention O\n, O\na O\nvital O\nmoment O\nin O\nhis O\nbid O\nfor O\na O\nsecond O\nterm O\n, O\nwas O\nmarred O\non O\nThursday O\nby O\nthe O\nresignation O\nof O\na O\ntop O\nadviser O\nin O\na O\nreported O\nsex O\nscandal O\n. O\n\nClinton B-PER\nwas O\nat O\nwork O\non O\nthe O\nnomination O\nacceptance O\nspeech O\nthat O\nwill O\nlaunch O\nhis O\n10-week O\nre-election O\ncampaign O\nwhen O\npolitical O\nstrategist O\nDick B-PER\nMorris I-PER\nabruptly O\nannounced O\nhis O\nresignation O\non O\nThursday O\n. O\n\nThe O\ntabloid O\nStar B-ORG\nmagazine I-ORG\nreported O\nthe O\nmarried O\nMorris B-PER\nhad O\na O\nlengthy O\naffair O\nwith O\na O\n$ O\n200-an-hour O\nprostitute O\nwho O\nhe O\nallowed O\nto O\neavesdrop O\non O\ntelephone O\nconversations O\nwith O\nClinton B-PER\n, O\nand O\nwith O\nwhom O\nhe O\nshared O\nWhite B-LOC\nHouse I-LOC\nspeeches O\nbefore O\nthey O\nwere O\nmade O\n. O\n\n\" O\nDick B-PER\nMorris I-PER\nis O\nmy O\nfriend O\n, O\nand O\nhe O\nis O\na O\nsuperb O\npolitical O\nstrategist O\n, O\n\" O\nClinton B-PER\nsaid O\nin O\na O\nwritten O\nstatement O\n. O\n\" O\n\nI O\nam O\nand O\nalways O\nwill O\nbe O\ngrateful O\nfor O\nthe O\ngreat O\ncontributions O\nhe O\nhas O\nmade O\nto O\nmy O\ncampaigns O\nand O\nfor O\nthe O\ninvaluable O\nwork O\nhe O\nhas O\ndone O\nfor O\nme O\nover O\nthe O\nlast O\ntwo O\nyears O\n. O\n\" O\n\nMorris B-PER\ndeclined O\nto O\naddress O\nthe O\nallegations O\ndirectly O\nin O\nhis O\nresignation O\nstatement O\nbut O\nsaid O\nhe O\nwas O\nquitting O\nto O\navoid O\nbecoming O\na O\ncampaign O\nissue O\n. O\n\nThe O\nsurprise O\ndevelopment O\ncaptivated O\nthe O\nthousands O\nof O\nreporters O\nat O\nthe O\nconvention O\nand O\nclearly O\nworried O\nsome O\nDemocrats B-MISC\n, O\nwho O\nhad O\nplanned O\na O\ntriumphal O\ncelebration O\nof O\nClinton B-PER\n's O\nlead O\nover O\nDole B-PER\nin O\nthe O\nopinion O\npolls O\n. O\n\nSenator O\nDianne B-PER\nFeinstein I-PER\n, O\na O\nCalifornia B-LOC\nDemocrat B-MISC\n, O\ncalled O\nit O\na O\n\" O\nbig O\nbump O\n\" O\nin O\nthe O\nway O\nof O\nthe O\nClinton B-PER\ncampaign O\n. O\n\n\" O\nIt O\ncomes O\nat O\nthe O\nworst O\npossible O\ntime O\non O\none O\nof O\nthe O\nbiggest O\ndays O\nfor O\nthe O\npresident O\n, O\n\" O\nFeinstein B-PER\nsaid O\n. O\n\nClinton B-PER\nwas O\nto O\ndeliver O\nhis O\nacceptance O\nspeech O\nat O\nthe O\nfinal O\nsession O\nof O\nthe O\nDemocratic B-MISC\nConvention I-MISC\nopening O\nat O\n8 O\np.m. O\nEDT O\n( O\nmidnight O\nGMT B-MISC\n) O\n. O\n\nThe O\n50-year-old O\npresident O\nhas O\nbeen O\ndogged O\nfor O\nyears O\nby O\nallegations O\nof O\nfinancial O\nwrongdoing O\n, O\nsexual O\nmisconduct O\nand O\nquestionable O\njudgment O\nin O\nselecting O\nhis O\nadvisers O\n. O\n\nRepublicans B-MISC\nhope O\nto O\nseize O\non O\nthe O\n\" O\ncharacter O\n\" O\nissue O\nto O\nbolster O\nClinton B-PER\n's O\nchallenger O\nBob B-PER\nDole I-PER\nin O\nthe O\nfinal O\nweeks O\nof O\nthe O\ncampaign O\n. O\n\nSpeaking O\nin O\nSanta B-LOC\nBarbara I-LOC\n, O\nCalifornia B-LOC\n, O\nDole B-PER\ndid O\nnot O\ndirectly O\nrefer O\nto O\nthe O\nsexual O\nscandal O\nbut O\nsaid O\nthe O\ndeparture O\nof O\nMorris B-PER\n, O\nwho O\nhad O\nadvised O\nClinton B-PER\nto O\nchart O\na O\nmore O\ncentrist O\npolitical O\ncourse O\n, O\nwould O\nmake O\nClinton B-PER\ndrift O\nback O\nto O\nthe O\nleft O\n. O\n\n\" O\nMorris B-PER\nhas O\nbeen O\ntrying O\nto O\nmake O\nPresident O\nClinton B-PER\na O\nRepublican B-MISC\n, O\nnow O\nmaybe O\nhe O\n'll O\nrevert O\nto O\nthe O\nliberal O\nDemocrat B-MISC\nthat O\nhe O\nreally O\nis O\n, O\n\" O\nDole B-PER\ntold O\nreporters O\n. O\n\nClinton B-PER\nwill O\nhit O\nthe O\nroad O\non O\nFriday O\nfor O\na O\nbus O\ntour O\nacross O\nseveral O\nstates O\nin O\nhis O\nfight O\nto O\nbecome O\nthe O\nfirst O\nDemocratic B-MISC\nincumbent O\nre-elected O\nto O\na O\nsecond O\nterm O\nsince O\nthe O\ndays O\nof O\nFranklin B-PER\nD. I-PER\nRoosevelt I-PER\n. O\n\nAides O\nsaid O\nClinton B-PER\nplanned O\nto O\nspend O\nmost O\nof O\nThursday O\nin O\nhis O\nhotel O\nroom O\nseveral O\nmiles O\n( O\nkm O\n) O\nfrom O\nthe O\nconvention O\nhall O\nworking O\non O\nhis O\nspeech O\n. O\n\nIt O\nwas O\napparently O\nneglected O\non O\nhis O\nlong O\n\" O\nwhistle-stop O\n\" O\ntrain O\ntrip O\nto O\nthe O\nconvention O\n, O\nduring O\nwhich O\nhe O\nrevelled O\nin O\ncontact O\nwith O\nfriendly O\ncrowds O\nacross O\nthe O\ncountry O\n's O\nheartland O\n. O\n\nHe O\nwas O\nalso O\nhoarse O\nand O\nwas O\ngiving O\nhis O\nvoice O\na O\nrest O\n. O\n\nBut O\nfirst O\nlady O\nHillary B-PER\nRodham I-PER\nClinton I-PER\ntold O\nABC B-ORG\ntelevision O\n, O\n\" O\nHe O\n's O\nreally O\nfired O\nup O\n. O\n\" O\n\n\" O\nHe O\nwants O\nto O\noutline O\nto O\nthe O\nAmerican B-MISC\npeople O\nwhat O\nhe O\nthinks O\nhas O\nbeen O\naccomplished O\nin O\nthe O\nlast O\nfour O\nyears O\n, O\nand O\nwhat O\nhe O\nwould O\nlike O\nto O\nsee O\ndone O\nin O\nthe O\nnext O\nfour O\nyears O\n, O\n\" O\nshe O\nsaid O\n. O\n\n\" O\nHe O\n's O\nvery O\nexcited O\nabout O\nthis O\nconvention O\n... O\n\nHe O\n's O\nexcited O\nabout O\nthe O\ncampaign O\n. O\n\nBut O\nmore O\nthan O\nthat O\n, O\nhe O\n's O\nvery O\nresolute O\nabout O\nwhat O\nhe O\nwants O\nto O\ndo O\n. O\n\" O\n\n\" O\nI O\ndo O\nn't O\ntake O\nanything O\nfor O\ngranted O\n. O\n\nI O\nalways O\nexpect O\nelections O\nto O\nget O\nclose O\n. O\n\nI O\nexpect O\nto O\nhave O\na O\ngreat O\ndeal O\nof O\nup O\nand O\ndown O\ndays O\nbetween O\nnow O\nand O\nthen O\n, O\n\" O\nshe O\nsaid O\nof O\nthe O\nNovember O\n5 O\nelection O\ndate O\n. O\n\nClinton B-PER\nis O\nleading O\nDole B-PER\nby O\nas O\nmuch O\nas O\n15 O\npoints O\naccording O\nto O\nsome O\npolls O\n. O\n\nThe O\ncampaign O\npits O\nDole B-PER\n, O\na O\nman O\nof O\nquick O\nand O\nwithering O\nwit O\nand O\nlong-time O\npublic O\nservice O\n, O\nbut O\nstilted O\nspeaking O\nstyle O\n, O\nagainst O\nthe O\nglib O\nand O\nconfident O\nClinton B-PER\n, O\nwho O\nhas O\nperfected O\na O\nstyle O\nthat O\nmakes O\ndirect O\neye O\ncontact O\nwith O\nhis O\naudience O\n. O\n\n-DOCSTART- O\n\nMontana B-LOC\nweekly O\nmuni O\nbond O\nindices O\n- O\nPiper B-ORG\nJaffray I-ORG\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nThe O\nfollowing O\nMontana B-LOC\ntax-exempt O\nmunicipal O\nbond O\nindices O\nwere O\ncompiled O\nby O\nPiper B-ORG\nJaffray I-ORG\nInc I-ORG\nfor O\nthe O\nweek O\nending O\nAugust O\n30 O\n. O\n\nPrevious O\n\n8/30 O\nWeek O\nChange O\n\n------------------------- O\n\nYear O\nA-rated O\nGen'l O\nObligation O\n4.45 O\n% O\n4.40 O\n% O\n+0.05 O\n\n10 O\nYear O\nA-rated O\nGen'l O\nObligation O\n4.90 O\n% O\n4.90 O\n% O\n----- O\n\n15 O\nYear O\nA-rated O\nGen'l O\nObligation O\n5.40 O\n% O\n5.35 O\n% O\n+0.05 O\n\n20 O\nYear O\nA-rated O\nGen'l O\nObligation O\n5.55 O\n% O\n5.50 O\n% O\n+0.05 O\n\n30 O\nYear O\nA-rated O\nHousing O\nRev O\n6.05 O\n% O\n6.00 O\n% O\n+0.05 O\n\n-- O\nU.S. B-ORG\nMunicipal I-ORG\nDesk I-ORG\n, O\n212-859-1650 O\n\n-DOCSTART- O\n\nResearchers O\nreport O\nprogress O\nin O\nmuscular O\ndystrophy O\n. O\n\nPHILADELPHIA B-LOC\n1996-08-29 O\n\nUniversity B-ORG\nof I-ORG\nPennsylvania I-ORG\nresearchers O\non O\nThursday O\nsaid O\na O\nnew O\ngene-therapy O\ntechnique O\nfor O\ntreating O\nmuscular O\ndystrophy O\ndisease O\nhad O\nshown O\nprogress O\nin O\nlaboratory O\nanimals O\n. O\n\nWord O\nof O\nthe O\nfindings O\n, O\nto O\nbe O\npublished O\nin O\nthe O\nOct. O\n1 O\nissue O\nof O\nthe O\njournal O\n\" O\nHuman B-ORG\nGene I-ORG\nTherapy I-ORG\n, O\n\" O\ncame O\nin O\nadvance O\nof O\nthe O\nannual O\nJerry B-MISC\nLewis I-MISC\nLabour I-MISC\nDay I-MISC\nweekend O\ntelethon O\nto O\nraise O\nmoney O\nfor O\nmuscular O\ndystrophy O\nresearch O\n. O\n\nSeveral O\nhurdles O\nmust O\nbe O\novercome O\nbefore O\nthe O\nmethod O\nis O\nused O\nin O\nhuman O\ntrials O\n. O\n\nNevertheless O\n, O\n\" O\na O\ntreatment O\nbased O\non O\nthe O\nnew O\nstrategy O\n.... O\nmay O\nhave O\nthe O\npotential O\nto O\nbenefit O\nmany O\npatients O\n, O\n\" O\nthe O\nUniversity B-ORG\nof I-ORG\nPennsylvania I-ORG\nMedical O\nCentre O\nsaid O\nin O\na O\nrelease O\n. O\n\nMuscular O\ndystrophy O\nis O\na O\nfatal O\nillness O\nin O\nwhich O\nthe O\nbody O\n's O\nmuscle O\ntissue O\ndegenerates O\nand O\nis O\nreplaced O\nby O\nfat O\n. O\n\nDeath O\nstrikes O\nin O\nearly O\nadulthood O\n. O\n\nIndividuals O\nwith O\nthe O\ndisease O\nhave O\na O\nnon-working O\nversion O\nof O\na O\ngene O\nresponsible O\nfor O\nproducing O\na O\ncrucial O\nmuscle O\nprotein O\ncalled O\ndystrophin O\n. O\n\nIn O\nthe O\nstudy O\nat O\nthe O\nUniversity O\n's O\nInstitute B-ORG\nfor I-ORG\nHuman I-ORG\nGene I-ORG\nTherapy I-ORG\n, O\nresearchers O\naltered O\na O\ncommon-cold O\nvirus O\nto O\ncarry O\na O\nversion O\nof O\nthe O\nworking O\ndystrophin O\ngene O\n. O\n\nThe O\nvirus O\n, O\nwhich O\nalso O\nwas O\naltered O\nto O\nminimise O\nits O\nsusceptibility O\nto O\nthe O\nimmune O\nsystem O\n, O\nwas O\nthen O\ninjected O\ninto O\nthe O\nmuscle O\ncells O\nof O\nmice O\nbred O\nto O\nlack O\ndystrophin O\ngenes O\n. O\n\nIn O\nthe O\nexperiment O\n, O\nbetween O\n30 O\nto O\n40 O\npercent O\nof O\nthe O\nmuscle O\nfibers O\nin O\none O\ngroup O\nof O\nmice O\nproduced O\ndystrophin O\nfor O\ntwo O\nweeks O\nbefore O\ndiminishing O\n. O\n\nSimilar O\nresults O\nhad O\nbeen O\nobtained O\npreviously O\nin O\ntest-tube O\ncell O\ncultures O\n, O\nbut O\nnot O\nin O\nlive O\nanimals O\n, O\nthe O\nuniversity O\nsaid O\n. O\n\nThe O\nuniversity O\nsaid O\nmethods O\nare O\nstill O\nneeded O\nto O\nmake O\nenough O\nof O\nthe O\naltered O\nvirus O\nto O\ntreat O\nhumans O\n, O\nto O\nfurther O\ndecrease O\nthe O\nimmune-system O\nresponse O\nto O\nthe O\nvirus O\n, O\nand O\nto O\ndeliver O\nthe O\nvirus O\nto O\nhuman O\nmuscle O\ntissue O\n. O\n\n-DOCSTART- O\n\nExport O\nBusiness O\n- O\nGrain O\n/ O\noilseeds O\ncomplex O\n. O\n\nCHICAGO B-LOC\n1996-08-29 O\n\nGrain O\nand O\noilseed O\nexports O\nreported O\nby O\nUSDA B-ORG\nand O\nprivate O\nexport O\nsources O\n. O\n\nWHEAT O\nSALES O\n- O\nTaiwan B-ORG\nFlour I-ORG\nMills I-ORG\nAssn I-ORG\nbought O\n98,000 O\ntonnes O\nof O\nU.S. B-LOC\nNo.1 O\nor O\nNo.2 O\nwheat O\nfrom O\nCargill B-ORG\n, O\nMitsui B-ORG\n, O\nContinental B-ORG\nand O\nLouis B-ORG\nDreyfus I-ORG\nCorp I-ORG\nfor O\nshipment O\nfrom O\nthe O\nPacific B-LOC\nNorthwest I-LOC\n. O\n\nFor O\nSept O\n10-30 O\n: O\n16,300 O\ntonnes O\nof O\ndark O\nnorthern O\nspring O\n( O\nDNS O\n) O\nat O\n$ O\n212.00 O\n; O\n7,000 O\nof O\nhard O\nred O\nwinter O\n( O\nHRW O\n) O\nat O\n$ O\n205.10 O\n; O\n2,700 O\nof O\nwestern O\nwhite O\n( O\nWW O\n) O\nat O\n$ O\n202.65 O\n. O\n\nFor O\nSept O\n20 O\n- O\nOct O\n10 O\n: O\n19,500 O\nof O\nDNS O\nat O\n$ O\n212.25 O\n, O\n10,000 O\nof O\nHRW O\nat O\n$ O\n204.74 O\n, O\n4,500 O\nof O\nWW O\nat O\n$ O\n199.71 O\n. O\n\nFor O\nSept O\n25 O\n- O\nOct O\n20 O\n: O\n23,500 O\nof O\nDNS O\nat O\n$ O\n212.25 O\n, O\n9,600 O\nHRW O\nat O\n$ O\n204.74 O\n, O\n4,900 O\nWW O\nat O\n$ O\n199.56 O\n. O\n\nWHEAT O\nSALES O\n- O\nThe O\nCommodity B-ORG\nCredit I-ORG\nCorp I-ORG\nof I-ORG\nUSDA I-ORG\nbought O\n18,278 O\ntonnes O\nof O\ndark O\nnorthern O\nspring O\n( O\nDNS O\n) O\nwheat O\nfrom O\nCargill B-ORG\nInc I-ORG\nat O\n$ O\n195.79 O\nper O\ntonne O\n, O\nFOB O\n, O\nfor O\ndonation O\nto O\nNicaragua B-LOC\n. O\n\nShipment O\nis O\nfor O\nNov O\n15 O\n- O\nDec O\n10 O\n. O\n\nWHEAT O\n/ O\nBARLEY O\nSALE O\n- O\nThe O\nJapanese B-ORG\nFood I-ORG\nAgency I-ORG\nsaid O\nit O\nbought O\n20,000 O\ntonnes O\nof O\nU.S. B-LOC\ndark O\nnorthern O\nspring O\nwheat O\n, O\n20,000 O\nof O\nCanadian B-MISC\nwestern O\nred O\nspring O\nwheat O\n, O\n20,000 O\nof O\nAustralian B-MISC\nstandard O\nwhite O\nwheat O\nand O\n20,000 O\nof O\nAustralian B-MISC\nfeed O\nbarley O\nat O\nits O\nweekly O\ntender O\n, O\nall O\nfor O\nOctober O\nshipment O\n. O\n\nSOYBEAN O\nSALES O\n- O\nThe O\nTaichung B-ORG\ndivision I-ORG\nof O\nTaiwan B-LOC\n's O\nBreakfast B-ORG\nSoybean I-ORG\nProcurement I-ORG\nAssn I-ORG\nbought O\n108,000 O\ntonnes O\nof O\nU.S. B-LOC\nsoybeans O\n. O\n\nBunge B-ORG\nsold O\nthe O\nfirst O\nshipment O\nand O\nCargill B-ORG\nthe O\nsecond O\n, O\ntraders O\nsaid O\n. O\n\nFor O\nNov O\n11-25 O\nfrom O\nthe O\nU.S. B-LOC\nGulf I-LOC\nor O\nNov O\n26 O\n- O\nDec O\n10 O\nfrom O\nPNW B-ORG\nit O\npaid O\n$ O\n0.8584 O\nper O\nbushel O\nover O\nCBOT O\nJanuary O\nsoybeans O\nand O\nfor O\nDec O\n6-20 O\nor O\nDec O\n21 O\n- O\nJan O\nit O\npaid O\n$ O\n.8787 O\nover O\nCBOT O\nJanuary O\n. O\n\n- O\nPakistan B-LOC\nbought O\n31,412 O\ntonnes O\nof O\nPL-480 O\nNo.2 O\nyellow O\nsoybeans O\nfrom O\nCargill B-ORG\nInc I-ORG\nfor O\n$ O\n303.19 O\nper O\ntonne O\n, O\nFOB O\nU.S. B-LOC\nGulf I-LOC\n, O\nagents O\nfor O\nthe O\nbuyer O\nsaid O\n. O\n\nThe O\nsoybeans O\nwere O\nfor O\nOct O\n15-30 O\nshipment O\n. O\n\nBARLEY O\nTENDER O\n- O\nThe O\nCyprus B-ORG\nGrain I-ORG\nCommission I-ORG\nsaid O\nit O\ninvited O\noffers O\nSeptember O\n3 O\nto O\nsupply O\n25,000 O\ntonnes O\nof O\nfeed O\nbarley O\n, O\nwith O\nshipment O\nfor O\nSept O\n25 O\n- O\nOct O\n10 O\nfrom O\nEurope B-LOC\nor O\nSept O\n15-30 O\nfrom O\nNorth B-LOC\nAmerica I-LOC\n. O\n\nMARKET O\nTALK O\n- O\nSri B-LOC\nLanka I-LOC\nplans O\nto O\nimport O\nup O\nto O\n400,000 O\ntonnes O\nof O\nrice O\nby O\nthe O\nend O\nof O\nthis O\nyear O\nto O\nmeet O\na O\ncrop O\nshortfall O\ncaused O\nby O\ndrought O\nand O\nrising O\ndemand O\n, O\ngovernment O\nofficials O\nsaid O\non O\nThursday O\n. O\n\nMARKET O\nTALK O\n- O\nUSDA B-ORG\nnet O\nchange O\nin O\nweekly O\nexport O\ncommitments O\nfor O\nthe O\nweek O\nended O\nAugust O\n22 O\n, O\nincludes O\nold O\ncrop O\nand O\nnew O\ncrop O\n, O\nwere O\n: O\nwheat O\nup O\n595,400 O\ntonnes O\nold O\n, O\nnil O\nnew O\n; O\ncorn O\nup O\n1,900 O\nold O\n, O\nup O\n319,600 O\nnew O\n; O\nsoybeans O\ndown O\n12,300 O\nold O\n, O\nup O\n300,800 O\nnew O\n; O\nupland O\ncotton O\nup O\n50,400 O\nbales O\nnew O\n, O\nnil O\nold O\n; O\nsoymeal O\n54,800 O\nold O\n, O\nup O\n100,600 O\nnew O\n, O\nsoyoil O\nnil O\nold O\n, O\nup O\n75,000 O\nnew O\n; O\nbarley O\nup O\n1,700 O\nold O\n, O\nnil O\nnew O\n; O\nsorghum O\n6,200 O\nold O\n, O\nup O\n156,700 O\nnew O\n; O\npima O\ncotton O\nup O\n4,000 O\nbales O\nold O\n, O\nnil O\nnew O\n; O\nrice O\nup O\n49,900 O\nold O\n, O\nnil O\nnew O\n... O\n\nUSDA B-ORG\nThursday O\nforecast O\nU.S. B-LOC\nagricultural O\nexports O\nin O\nfiscal O\nyear O\n1997 O\nwould O\ndecline O\nto O\n$ O\n58 O\nbillion O\n, O\ndown O\n$ O\n2 O\nbillion O\nfrom O\nthe O\nrecord O\n$ O\n60 O\nbillion O\nseen O\nfor O\nfiscal O\n1996 O\n. O\n\nOilseed O\nexports O\nare O\nexpected O\nto O\nrise O\nby O\n$ O\n800 O\nmillion O\nand O\nlivestock O\n, O\npoultry O\nand O\nfruits O\nand O\nvegetables O\nare O\nseen O\ngaining O\nmore O\nthan O\n$ O\n1 O\nbillion O\n. O\n\nUSDA B-ORG\npegged O\nU.S. B-LOC\nwheat O\nexports O\nat O\n25.0 O\nmillion O\ntonnes O\nin O\nfiscal O\n1997 O\nversus O\n32.0 O\nmillion O\ntonnes O\nthe O\nprior O\nyear O\n... O\n\nThe O\nEuropean B-ORG\nUnion I-ORG\nagreed O\non O\nThursday O\nto O\nincrease O\nby O\n300,000 O\ntonnes O\nthe O\nquota O\nof O\nGerman B-MISC\nintervention O\nbarley O\navailable O\nfor O\nexport O\n, O\nFrance B-LOC\nONIC B-ORG\nsaid O\n. O\n\nThe O\nEU B-ORG\n's O\ngrain O\npanel O\nwill O\nadd O\ntwo O\ntranches O\nof O\n150,000 O\ntonnes O\neach O\nto O\nthe O\nexisting O\nallocation O\n, O\nit O\nsaid O\n. O\n\n-- O\nChicago B-LOC\nnewsdesk O\n312-408-8720-- O\n\n-DOCSTART- O\n\nUSDA B-ORG\ngross O\ncutout O\nhide O\nand O\noffal O\nvalue O\n. O\n\nDES B-LOC\nMOINES I-LOC\n1996-08-29 O\n\nThe O\nhide O\nand O\noffal O\nvalue O\nfrom O\na O\ntypical O\nslaughter O\nsteer O\nfor O\nThursday O\nwas O\nestimated O\nat O\n$ O\n9.76 O\nper O\ncwt O\nlive O\n, O\nup O\n$ O\n0.03 O\nwhen O\ncompared O\nwith O\nWednesday O\n's O\nvalue O\n. O\n\n- O\nUSDA B-ORG\n\n-DOCSTART- O\n\nHelp-wanted O\nad O\nindex O\nfell O\nin O\nJuly O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nThe O\nhelp-wanted O\nadvertising O\nindex O\nfell O\nin O\nJuly O\n, O\nthe O\nConference B-ORG\nBoard I-ORG\nsaid O\nThursday O\n, O\nreflecting O\nthe O\nuneven O\nnature O\nof O\nthe O\nnation O\n's O\nlabour O\nmarkets O\n. O\n\nThe O\nmonthly O\nindex O\nfell O\nto O\n83.0 O\nin O\nJuly O\nagainst O\na O\nreading O\nof O\n85.0 O\nin O\nJune O\n, O\nthe O\nprivate O\nbusiness O\nresearch O\ngroup O\nsaid O\n. O\n\nIn O\nJuly O\n, O\nthe O\nvolume O\nof O\nhelp-wanted O\nadvertising O\nfell O\nin O\nfive O\nof O\nthe O\nnine O\nU.S. B-LOC\nregions O\n. O\n\n\" O\nThe O\nlabour O\nmarket O\nhas O\nbeen O\nexpanding O\nthroughout O\n1996 O\n, O\nbut O\nin O\na O\nvery O\nuneven O\npattern O\n, O\n\" O\nConference B-ORG\nBoard I-ORG\neconomist O\nKen B-PER\nGoldstein I-PER\nsaid O\n. O\n\" O\n\nRecent O\nwant-ad O\nfigures O\nindicate O\nthat O\nconservative O\nhiring O\nplans O\nare O\nkeeping O\njob O\ngrowth O\nbelow O\nthe O\nrate O\nof O\noverall O\neconomic O\nactivity O\n. O\n\" O\n\nWith O\n2.5 O\npercent O\ngross O\ndomestic O\nproduct O\ngrowth O\nexpected O\nfor O\n1996 O\n, O\nnew O\njob O\ngrowth O\nshould O\nslowly O\nlower O\nthe O\nunemployment O\nrate O\nover O\nthe O\nrest O\nof O\nthe O\nyear O\n. O\n\n\" O\nWith O\nthe O\nunemployment O\nrate O\nstaying O\nclose O\nto O\nabout O\n5.5 O\npercent O\nover O\nthe O\nlast O\ntwo O\nyears O\n, O\nthere O\nis O\na O\ngood O\nchance O\nthe O\nrate O\nwill O\nslowly O\ndrop O\nto O\nabout O\n5.0 O\npercent O\nby O\nthe O\nend O\nof O\nthe O\nyear O\n, O\n\" O\nGoldstein B-PER\nsaid O\n. O\n\nThe O\nJuly O\nindex O\nmatched O\nthe O\nreading O\nfor O\nJuly O\n, O\n1995 O\n. O\n\nThe O\ngreatest O\ndeclines O\nin O\nthe O\nvolume O\nof O\nhelp-wanted O\nadvertising O\nwere O\nin O\nthe O\nNew B-LOC\nEngland I-LOC\n, O\nMountain B-LOC\nand O\nWest B-LOC\nSouth I-LOC\nCentral I-LOC\nregions O\n. O\n\nThe O\ngreatest O\nincrease O\nwas O\nin O\nthe O\nEast B-LOC\nNorth I-LOC\nCentral I-LOC\nregion O\n. O\n\n-DOCSTART- O\n\nPolice O\nseek O\nsuspects O\nin O\nAtlantic B-LOC\nCity I-LOC\njewel O\nheist O\n. O\n\nATLANTIC B-LOC\nCITY I-LOC\n, O\nN.J. B-LOC\n1996-08-29 O\n\nAtlantic B-LOC\nCity I-LOC\npolice O\nsaid O\nThursday O\nthey O\nwere O\nseeking O\ntwo O\nmen O\nand O\ntwo O\nwomen O\nin O\nconnection O\nwith O\na O\n$ O\n690,000 O\ntheft O\nof O\njewelry O\nand O\ncash O\nfrom O\na O\nguest O\nof O\nthe O\nShowboat O\nHotel O\nand O\nCasino O\n. O\n\nCapt O\n. O\n\nRichard B-PER\nAndrews I-PER\nsaid O\npolice O\nwere O\nseeking O\na O\nman O\nshown O\non O\na O\nhotel O\nvideotape O\ncarrying O\na O\nsuitcase O\nresembling O\nthe O\nvictim O\n's O\n. O\n\" O\n\nWe O\nwant O\nto O\ntalk O\nto O\nhim O\n, O\n\" O\nAndrews B-PER\nsaid O\nof O\nthe O\nman O\n. O\n\nA O\nsecond O\nman O\nand O\ntwo O\nwomen O\nalso O\nwere O\nbeing O\nsought O\n. O\n\nThe O\nthefts O\noccurred O\nSunday O\nwhen O\nthe O\nvictim O\n, O\nNew B-LOC\nYork I-LOC\njewelry O\nwholesaler O\nJerry B-PER\nSchein I-PER\n, O\nleft O\nthree O\nsuitcases O\nin O\na O\ncloset O\nat O\nSomerset B-ORG\nJewellers I-ORG\nin O\nthe O\nhotel O\nwhile O\nhe O\nchecked O\nout O\n. O\n\nWhile O\nhe O\nwas O\ngone O\n, O\ntwo O\nwomen O\nin O\ntheir O\nmid-twenties O\nand O\nan O\nolder O\nman O\nentered O\nthe O\njewelry O\nstore O\nand O\ntried O\nto O\ndistract O\nstore O\nowner O\nCharles B-PER\nMcGilley I-PER\n. O\n\nWhen O\nSchein B-PER\nreturned O\ntwo O\nof O\nthe O\nsuitcases O\nwere O\nmissing O\n. O\n\nThey O\ncontained O\n$ O\n650,000 O\nin O\njewelry O\nand O\n$ O\n40,000 O\nin O\ncash O\n, O\nAndrews B-PER\nsaid O\n. O\n\nHe O\nsaid O\nthe O\nman O\non O\nthe O\nvideotape O\ndid O\nnot O\nmatch O\nthe O\ndescription O\ngiven O\nby O\nthe O\njewelry O\nstore O\nowner O\n. O\n\n-DOCSTART- O\n\nO.J. B-PER\nSimpson I-PER\nhints O\nat O\nmore O\nsupporting O\nevidence O\n. O\n\nJackie B-PER\nFrank I-PER\n\nWASHINGTON B-LOC\n1996-08-29 O\n\nO.J. B-PER\nSimpson I-PER\nsaid O\non O\nThursday O\nhe O\nwas O\nfinancially O\nbroken O\nby O\nhis O\ndefence O\nagainst O\nmurder O\ncharges O\nbut O\nhe O\nwas O\nhopeful O\nnew O\nevidence O\nto O\nsupport O\nhim O\nwould O\nbe O\navailable O\nfor O\na O\ncivil O\ntrial O\nnext O\nmonth O\n. O\n\nThe O\nformer O\nfootball O\nstar O\nwas O\nfound O\nnot O\nguilty O\nby O\na O\ncriminal O\ntrial O\njury O\nlast O\nOctober O\nof O\nthe O\nmurders O\nof O\nhis O\nformer O\nwife O\n, O\nNicole B-PER\nBrown I-PER\nSimpson I-PER\n, O\nand O\nher O\nfriend O\n, O\nRonald B-PER\nGoldman I-PER\n, O\nin O\nJune O\n1994 O\n. O\n\nHe O\nnow O\nfaces O\na O\ncivil O\nsuit O\nbrought O\nby O\nfamilies O\nof O\nthe O\nvictims O\nwho O\nhold O\nhim O\nresponsible O\nfor O\nthe O\ndeaths O\n. O\n\nHe O\ntold O\nreporters O\na O\ncourt O\norder O\nnot O\nto O\ntalk O\nabout O\nhis O\ncase O\nkept O\nhim O\nfrom O\ndetailing O\nhow O\nhe O\nhas O\nfulfilled O\nhis O\npledge O\nto O\nfind O\nthe O\nkillers O\n. O\n\nBut O\nhe O\nadded O\nwithout O\nelaborating O\n, O\n\" O\nhopefully O\nwe O\nwill O\nsee O\nsome O\nthings O\ncome O\nout O\nin O\nthis O\nnext O\ntrial O\n. O\n\" O\n\nThe O\njudge O\nin O\nthe O\ncivil O\ntrial O\nhas O\nimposed O\na O\nsweeping O\ngag O\norder O\nthat O\nprohibits O\nlawyers O\n, O\nwitnesses O\nand O\nparties O\nto O\nthe O\ncase O\nfrom O\ndiscussing O\nit O\nwith O\nthe O\nmedia O\nor O\nelsewhere O\nin O\npublic O\n. O\n\n\" O\nI O\nwould O\nlove O\nto O\nspeak O\nabout O\neverything O\n, O\n\" O\nsaid O\nSimpson B-PER\n, O\nwho O\nvowed O\nafter O\nhis O\nacquittal O\nto O\nfind O\nthe O\nkillers O\nand O\noffered O\na O\nsubstantial O\nreward O\n. O\n\nHis O\nlawyers O\nhave O\nsaid O\nhis O\ndefence O\nin O\nthe O\ncivil O\ntrial O\nthat O\nstarts O\nSept O\n. O\n\n17 O\nwill O\nbe O\nthat O\nhe O\ndid O\nnot O\nkill O\nthe O\nvictims O\n. O\n\nSimpson B-PER\nsaid O\nat O\nthe O\nhotel O\nnews O\nconference O\nhis O\nplans O\ninclude O\neventually O\nwriting O\nanother O\nbook O\n. O\n\nHe O\nadded O\nthat O\nhe O\nhas O\nhad O\njob O\noffers O\nbut O\nmore O\nhave O\ncome O\nfrom O\nabroad O\nthan O\nat O\nhome O\n. O\n\n\" O\nI O\n'm O\nbroke O\n. O\n\nI O\nam O\nnot O\ncrying O\nthe O\nblues O\n. O\n\nI O\ncan O\nget O\nalong O\njust O\nfine O\n, O\n\" O\nhe O\nsaid O\n. O\n\" O\n\nWhatever O\nyou O\nwant O\nto O\nsend O\nme O\n, O\nI O\nneed O\n. O\n\" O\n\nHe O\nagain O\naccused O\nthe O\nnews O\nmedia O\nof O\nerroneous O\nreporting O\non O\nhis O\ncase O\nbut O\ndid O\nnot O\nsignal O\nany O\nplans O\nfor O\nlawsuits O\nas O\nhe O\ndid O\non O\nWednesday O\nin O\nan O\naddress O\nat O\na O\njam-packed O\nWashington B-LOC\nchurch O\n. O\n\nContrary O\nto O\nnews O\nreports O\n, O\nSimpson B-PER\nsaid O\n, O\nhe O\nhas O\nreceived O\nsupport O\nfrom O\nboth O\nblacks O\nand O\nwhites O\n. O\n\nHe O\nagain O\ndismissed O\ncharges O\nthat O\nhe O\nhad O\ndistanced O\nhimself O\nfrom O\nthe O\nblack O\ncommunity O\nduring O\nhis O\nsuccessful O\nfootball O\nand O\ncommercial O\ncareer O\n, O\nonly O\nto O\nseek O\ntheir O\nsupport O\nafter O\nhe O\nfaced O\nmurder O\ncharges O\n. O\n\nA O\ncrowd O\nof O\n2,000 O\npaid O\n$ O\n10 O\na O\nhead O\nto O\nhear O\nthe O\nformer O\nstar O\nrunning O\nback O\nfor O\nthe O\nBuffalo B-ORG\nBills I-ORG\nprofessional O\nfootball O\nclub O\nand O\na O\nFootball B-MISC\nHall I-MISC\nof I-MISC\nFame I-MISC\nmember O\non O\nWednesday O\nnight O\n. O\n\nThe O\ncrowd O\nin O\nthe O\nchurch O\nwas O\nwildly O\nsupportive O\n, O\nshowering O\nSimpson B-PER\nwith O\ngifts O\nand O\npraise O\n. O\n\nBut O\noutside O\n, O\ndozens O\nof O\nprotesters O\nfrom O\nthe O\nD.C. B-ORG\nCoalition I-ORG\nAgainst I-ORG\nDomestic I-ORG\nViolence I-ORG\ncalled O\nfor O\nthe O\nchurch O\nto O\nsupport O\nvictims O\nof O\nviolence O\ninstead O\n. O\n\n-DOCSTART- O\n\nClinton B-PER\nadviser O\nMorris B-PER\nannounces O\nresignation O\n. O\n\nCHICAGO B-LOC\n1996-08-29 O\n\nPresident O\nBill B-PER\nClinton I-PER\n's O\ntop O\npolitical O\nstrategist O\nDick B-PER\nMorris I-PER\nresigned O\non O\nThursday O\n, O\nsaying O\nhe O\ndid O\nnot O\nwant O\nto O\nbecome O\nan O\nissue O\nin O\nClinton B-PER\n's O\nre-election O\ncampaign O\n. O\n\nIn O\na O\nwritten O\nstatement O\n, O\ndistributed O\nby O\nthe O\nClinton B-PER\ncampaign O\n, O\nMorris B-PER\navoided O\ncomment O\non O\npublished O\nallegations O\nthat O\nhe O\nhad O\nengaged O\nin O\na O\nyear-long O\naffair O\nwith O\na O\n$ O\n200-an-hour O\nprostitute O\n. O\n\nThe O\nstatement O\nfrom O\nMorris B-PER\nsaid O\nthat O\nhe O\nhad O\nsubmitted O\nhis O\nresignation O\non O\nWednesday O\nnight O\n. O\n\" O\n\nWhile O\nI O\nserved O\nI O\nsought O\nto O\navoid O\nthe O\nlimelight O\nbecause O\nI O\ndid O\nnot O\nwant O\nto O\nbecome O\nthe O\nmessage O\n. O\n\nNow O\n, O\nI O\nresign O\nso O\nI O\nwill O\nnot O\nbecome O\nthe O\nissue O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\nannouncement O\nfollowed O\na O\nreport O\nin O\nthe O\nweekly O\nsupermarket O\ntabloid O\nStar B-ORG\nmagazine I-ORG\n, O\nreprinted O\nin O\nThursday O\n's O\neditions O\nof O\nthe O\nNew B-ORG\nYork I-ORG\nPost I-ORG\n, O\nthat O\nthe O\nmarried O\nadviser O\nhad O\nhired O\na O\n37-year-old O\nprostitute O\non O\na O\nweekly O\nbasis O\nwhile O\nvisiting O\nWashington B-LOC\nto O\nadvise O\nClinton B-PER\non O\nhis O\nre-election O\ncampaign O\n. O\n\n\" O\nI O\nwill O\nnot O\nsubject O\nmy O\nwife O\n, O\nfamily O\nor O\nfriends O\nto O\nthe O\nsadistic O\n, O\nvitriol O\nof O\nyellow O\njournalism O\n. O\n\nI O\nwill O\nnot O\ndignify O\nsuch O\njournalism O\nwith O\na O\nreply O\nor O\nan O\nanswer O\n. O\n\nI O\nnever O\nwill O\n, O\n\" O\nhis O\nstatement O\nsaid O\n. O\n\nIt O\nwas O\ndistributed O\nto O\nreporters O\nat O\nthe O\npress O\ncentre O\nof O\nClinton B-PER\n's O\nDemocratic B-MISC\nconvention O\nheadquarters O\njust O\nhours O\nbefore O\nthe O\npresident O\nwas O\nto O\naddress O\nthe O\ndelegates O\naccepting O\nthe O\nparty O\n's O\nnomination O\nfor O\na O\nsecond O\nfour-year O\nterm O\nin O\nthe O\nWhite B-LOC\nHouse I-LOC\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nsurgeon O\ninvestigated O\nfor O\ndiscarding O\nfoot O\n. O\n\nCHARLESTON B-LOC\n, O\nS.C. B-LOC\n1996-08-29 O\n\nHealth O\nofficials O\nsaid O\non O\nThursday O\nthey O\nwere O\ninvestigating O\nthe O\ndiscovery O\nof O\nan O\namputated O\nfoot O\non O\na O\nbeach O\nnear O\nCharleston B-LOC\nto O\ndetermine O\nwhether O\na O\nlocal O\nsurgeon O\nhad O\nimproperly O\ndisposed O\nof O\ninfectious O\nwaste O\n. O\n\nThe O\nfoot O\n, O\nwhich O\nwashed O\nup O\non O\nSullivan B-LOC\n's I-LOC\nIsland I-LOC\nbeach O\nthis O\nmonth O\n, O\nwas O\namputated O\nthree O\nyears O\nago O\nfrom O\na O\nchild O\nwhose O\nlegs O\nwere O\ndeformed O\n. O\n\nThe O\nfoot O\nhad O\nto O\nbe O\nremoved O\nso O\nthe O\ninfant O\ncould O\nbe O\nfitted O\nwith O\na O\nprosthesis O\n. O\n\nAn O\northopedic O\nsurgeon O\nwas O\ngiven O\npermission O\nby O\nthe O\nchild O\n's O\nparents O\nand O\nthe O\nhospital O\nto O\nkeep O\nthe O\nfoot O\nfor O\nresearch O\nand O\neducational O\npurposes O\n. O\n\nHealth O\nofficials O\nsaid O\nthe O\nsurgeon O\ntold O\nauthorities O\nhe O\nstored O\nthe O\nfoot O\nin O\nhis O\nfreezer O\nat O\nhome O\n, O\nbut O\nthe O\nfreezer O\nrecently O\nbroke O\ndown O\nand O\nthe O\ncontents O\nspoiled O\n. O\n\nThe O\nsurgeon O\n, O\nwho O\napologised O\nfor O\nthe O\nincident O\n, O\nsaid O\nhe O\ndecided O\nto O\nput O\nthe O\nfoot O\nin O\na O\ncrab O\ntrap O\nto O\nremove O\nthe O\nflesh O\n. O\n\nThe O\nfoot O\nlater O\nwashed O\nup O\non O\nthe O\nbeach O\n. O\n\n-DOCSTART- O\n\nFlorida B-LOC\ncop O\ndisguised O\nas O\nshrub O\nnabs O\nbad O\nguys O\n. O\n\nMIAMI B-LOC\n1996-08-29 O\n\nIt O\nwas O\na O\nbush O\nthat O\nbagged O\nthe O\nbad O\nguys O\n. O\n\nWhen O\nfour O\nwould-be O\nrobbers O\n, O\narmed O\nand O\nmasked O\n, O\nshowed O\nup O\nto O\nrob O\na O\nChecker B-ORG\n's I-ORG\nrestaurant O\nin O\nthe O\nFort B-LOC\nLauderdale I-LOC\nsuburb O\nof O\nPembroke B-LOC\nPines I-LOC\non O\nTuesday O\n, O\nthey O\nhad O\nno O\nidea O\nthe O\nshrub O\nnear O\nthe O\ndrive-through O\nwindow O\nwas O\ntoting O\na O\nshotgun O\n. O\n\nDetective O\nEarl B-PER\nFeugill I-PER\n, O\ncamouflaged O\nas O\na O\nshaggy O\ngreen O\nbush O\n, O\nordered O\nthem O\nto O\nfreeze O\n. O\n\" O\n\nThey O\nwere O\nquite O\nsurprised O\n, O\n\" O\nhe O\ntold O\nthe O\nMiami B-ORG\nHerald I-ORG\n. O\n\nFeugill B-PER\nsaid O\nhe O\nmade O\nthe O\nhot O\n, O\nheavy O\nsuit O\n, O\nwhich O\nhe O\nfirst O\nused O\nin O\nthe O\nMarines B-ORG\n, O\nby O\nattaching O\nstrips O\nof O\nburlap O\nto O\na O\ncamouflage O\noutfit O\n. O\n\nGreen B-PER\nand O\nblack O\nface O\npaint O\ncompleted O\nhis O\ndisguise O\n. O\n\nHe O\nwas O\nstaking O\nout O\nthe O\nrestaurant O\nafter O\na O\nseries O\nof O\nrobberies O\nat O\nlocal O\nfast-food O\nplaces O\n. O\n\nPembroke B-LOC\nPines I-LOC\npolice O\nsaid O\nfive O\npeople O\nwere O\narrested O\nas O\na O\nresult O\nof O\nthe O\n90-minute O\nstakeout O\n, O\nincluding O\nthe O\nfour O\nrobbers O\nand O\na O\nrestaurant O\nemployee O\nwho O\nwas O\nallegedly O\nprepared O\nto O\nlet O\nthem O\nin O\na O\nback O\ndoor O\n. O\n\n-DOCSTART- O\n\nU.S. B-ORG\nDLA I-ORG\nsets O\ntin O\nprice O\nat O\n$ O\n2.7975 O\nper O\nlb O\n. O\n\nWASHINGTON B-LOC\n1996-08-29 O\n\nThe O\nU.S. B-ORG\nDefense I-ORG\nLogistics I-ORG\nAgency I-ORG\nset O\nThursday O\n's O\noffering O\nprice O\nfor O\nstockpile O\ntin O\nat O\n$ O\n2.7975 O\nper O\nlb O\n, O\nversus O\n$ O\n2.7775 O\nper O\nlb O\nyesterday O\n. O\n\n-DOCSTART- O\n\nKey O\nClinton B-PER\naide O\nresigns O\n, O\nNBC B-ORG\nsays O\n. O\n\nCHICAGO B-LOC\n1996-08-29 O\n\nDick B-PER\nMorris I-PER\n, O\nthe O\nRepublican B-MISC\npolitical O\nconsultant O\nwho O\nreshaped O\nU.S. B-LOC\nPresident O\nBill B-PER\nClinton I-PER\n's O\nreelection O\ncampaign O\n, O\nhas O\nresigned O\n, O\nMS-NBC B-MISC\nNews I-MISC\nreported O\nThursday O\n. O\n\nMorris B-PER\ndrew O\nthe O\nire O\nof O\nliberal O\nClinton B-PER\naides O\nfor O\nrepositioning O\nthe O\npresident O\nin O\nthe O\npolitical O\ncentre O\n. O\n\nThere O\nwas O\nno O\nimmediate O\ncomment O\non O\nthe O\nreport O\nfrom O\nthe O\nWhite B-LOC\nHouse I-LOC\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\ncorn O\ngluten O\nmeal O\nsteady-higher O\n, O\nfeed O\nflat O\n. O\n\nCHICAGO B-LOC\n1996-08-29 O\n\nU.S. B-LOC\ncorn O\ngluten O\nfeed O\nprices O\nwere O\nflat O\nwhile O\nmeal O\nvalues O\nwere O\nsteady O\nto O\nfirmer O\non O\nThursday O\n. O\n\nDealers O\nnoted O\na O\nseasonal O\npickup O\nin O\nmeal O\ndemand O\n. O\n\n-- O\n\nCHICAGO B-MISC\nAREA I-MISC\nMILLS I-MISC\n( O\ndollars O\nper O\nshort O\nton O\n) O\n\nGluten O\nfeed O\n21 O\npct O\nbulk O\nSpot O\n- O\n117.00 O\nunc O\n\nGluten O\nfeed O\npellets O\nSpot O\n- O\nunq O\n\nGluten O\nmeal O\n60 O\npct O\nbulk O\nrail O\nSpot O\n- O\n320.00 O\nup O\n5 O\n\nDECATUR B-ORG\n, O\nIL B-LOC\n/ O\nCLINTON B-ORG\nAND I-ORG\nCEDAR I-ORG\nRAPIDS I-ORG\n, O\nIA B-LOC\n\nGluten O\nfeed O\n18 O\npct O\npellets O\nSpot O\n- O\n117.00 O\nunc O\n\nGluten O\nmeal O\n60 O\npct O\nbulk O\nSpot O\n- O\n310.00 O\nunc O\n\n( O\nChicago B-LOC\nnewsdesk O\n312-408-8720 O\n) O\n\n-DOCSTART- O\n\nEU B-ORG\nbarley O\nsale O\nworth O\n$ O\n145 O\n/ O\nT O\n, O\nfor O\nSaudi B-MISC\n- O\nsources O\n. O\n\nPARIS B-LOC\n1996-08-29 O\n\nA O\nEuropean B-ORG\nUnion I-ORG\nsale O\nof O\n234,324 O\ntonnes O\nof O\nGerman B-MISC\nintervention O\nbarley O\nis O\nworth O\nsome O\n$ O\n145 O\nper O\ntonne O\nfob O\nGermany B-LOC\nand O\nis O\nmostly O\ndestined O\nfor O\nSaudi B-LOC\nArabia I-LOC\n, O\nEuropean B-MISC\ngrain O\nsources O\nsaid O\non O\nThursday O\n. O\n\nThe O\nEU B-ORG\n's O\ncereals O\nmanagement O\ncommittee O\nsold O\n234,324 O\ntonnes O\nof O\nGerman B-MISC\nintervention O\nbarley O\nat O\na O\nminimum O\nprice O\nof O\n105.07 O\nEcus B-MISC\nper O\ntonne O\n. O\n\nSaudi B-LOC\nArabia I-LOC\nprovisionally O\nbought O\n800,000 O\ntonnes O\nof O\noptional-origin O\nbarley O\nat O\nan O\nAugust O\n21 O\ntender O\nat O\nprices O\nbetween O\n$ O\n160 O\nand O\n$ O\n162 O\nincluding O\ncost O\n, O\ninsurance O\nand O\nfreight O\n, O\ntraders O\nsaid O\nlast O\nweek O\n. O\n\nBut O\nEuropean B-MISC\ngrain O\ntraders O\nand O\nofficials O\nsaid O\nthe O\nSaudis B-MISC\nmight O\nreduce O\nthe O\npurchase O\nto O\n600,000 O\ntonnes O\n. O\n\nTraders O\nhave O\nsaid O\na O\nsubstantial O\npart O\nof O\nthe O\ndeal O\nwas O\nlikely O\nto O\ncome O\nfrom O\nthe O\nEuropean B-ORG\nUnion I-ORG\n, O\nwhich O\nenjoys O\na O\nsupply O\nand O\nfreight O\nadvantage O\nover O\nother O\nproducers O\n. O\n\nBut O\nsubtracting O\nfreight O\ncosts O\n, O\nthe O\nequivalent O\nfob O\nprice O\nof O\nthe O\ndeal O\nis O\naround O\n$ O\n142 O\n, O\nwell O\nbelow O\nthe O\n$ O\n149 O\nper O\ntonne O\nfloor O\nprice O\nwhich O\nthe O\nEU B-ORG\nput O\non O\nits O\nbarley O\nas O\nnews O\nof O\nthe O\ndeal O\nemerged O\nlast O\nweek O\n. O\n\nLast O\nThursday O\nthe O\nEU B-ORG\nsold O\n34,277 O\ntonnes O\nof O\nGerman B-MISC\nintervention O\nbarley O\nat O\na O\nminimum O\nprice O\nof O\n109.36 O\nEcus B-MISC\nper O\ntonne O\n, O\nwhich O\nwas O\nseen O\nas O\nworth O\n$ O\n149 O\nper O\ntonne O\nfob O\n. O\n\n-- O\nParis B-LOC\nnewsroom O\n+331 O\n4221 O\n5432 O\n\n-DOCSTART- O\n\nFrench B-MISC\nshipyard O\nworkers O\nmarch O\nagainst O\njob O\ncuts O\n. O\n\nRENNES B-ORG\n1996-08-29 O\n\nAbout O\n3,500 O\nnaval O\nshipyard O\nworkers O\nmarched O\nin O\nthe O\ncentre O\nof O\nthe O\nnorthern O\nport O\ntown O\nof O\nCherbourg B-LOC\non O\nThursday O\nto O\nprotest O\nagainst O\ndefence O\nrestructuring O\n, O\na O\nunion O\nofficial O\nsaid O\n. O\n\nThe O\nlocal O\npolice O\nheadquarters O\ndid O\nnot O\ngive O\na O\nfigure O\nbut O\nsaid O\n1,800 O\nworkers O\nat O\nthe O\nCherbourg B-LOC\nyeard O\nhad O\nstopped O\nwork O\n. O\n\nA O\ncutback O\nplan O\ncould O\nslim O\ntheir O\nnumbers O\nto O\n1,700 O\nfrom O\n4,200 O\n. O\n\nSeveral O\nhundred O\nworkers O\nalso O\nmarched O\nin O\nthe O\nwestern O\ntown O\nof O\nIndre B-LOC\nwhere O\n500 O\nor O\n1,600 O\njobs O\nare O\nat O\nrisk O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nPakistan B-LOC\n- O\nAugust O\n29 O\n. O\n\nFollowing O\nare O\nsome O\nof O\nthe O\nmain O\nstories O\nin O\nThursday O\n's O\nPakistani B-MISC\nnewspapers O\n: O\n\nDAWN B-ORG\n\n- O\nThe O\ngovernment O\nhas O\ndecided O\nto O\ntransfer O\nthe O\nentire O\ndistribution O\nnetwork O\nof O\nelectricity O\nto O\nforeign O\nmanagements O\nto O\ncurtail O\nlosses O\nof O\nbillions O\nof O\nrupees O\n. O\n\n- O\nThe O\ngovernment O\nhas O\nsuffered O\na O\nloss O\nof O\n11 O\nbillion O\nrupees O\ndue O\nto O\ntax O\nholidays O\nat O\nindustrial O\nestates O\nin O\nHub B-LOC\nand O\nGadoon B-LOC\n. O\n\n- O\nHigh O\nCourt O\nofficials O\nhave O\nunearthed O\npolice-run O\nhuman O\ncages O\nat O\nTando B-LOC\nAllahyar I-LOC\nnear O\nHyderabad B-LOC\n. O\n\nSome O\n27 O\npeople O\nwere O\nrescued O\nfrom O\nthe O\nprivate O\njail O\nset O\nup O\nby O\nthe O\npolice O\n. O\n\n- O\nOpposition O\nleader O\nNawaz B-PER\nSharif I-PER\nrenewed O\na O\npledge O\nto O\noust O\nthe O\nPakistan B-ORG\nPeople I-ORG\n's I-ORG\nParty I-ORG\ngovernment O\nheaded O\nby O\nPrime O\nMinister O\nBenazir B-PER\nBhutto I-PER\n. O\n\nBUSINESS B-ORG\nRECORDER I-ORG\n\n- O\nGas O\nprices O\nmay O\ngo O\nup O\nby O\nfive O\npercent O\nto O\nincrease O\nthe O\nrate O\nof O\nreturn O\nof O\nSui B-ORG\nSouthern I-ORG\nGas I-ORG\nand O\nSui B-ORG\nNorthern I-ORG\nGas I-ORG\ncompanies O\n. O\n\n- O\nJapan B-LOC\nis O\nimporting O\n80 O\npercent O\nof O\ncotton O\nyarn O\nfrom O\nPakistan B-LOC\nevery O\nyear O\n. O\n\n- O\nThe O\ngovernment O\nhas O\nblamed O\nsugar O\ntechnologists O\nfor O\nnot O\nsupporting O\na O\nlong-term O\nprogramme O\nof O\nresearch O\nand O\ndevelopment O\nto O\nincrease O\nproduction O\nof O\nsugarcane O\n. O\n\nFINANCIAL B-ORG\nPOST I-ORG\n\n- O\nArmed O\nrobbers O\npillaged O\n70 O\nbarrels O\nof O\ncrude O\noil O\nfrom O\na O\nwell O\nnear O\nGujar B-LOC\nKhan I-LOC\non O\nWednesday O\n. O\n\n- O\nPakistan B-LOC\nwill O\npay O\nan O\nadditional O\nbill O\nof O\n$ O\n244 O\nmillion O\nas O\nprivate O\npower O\nprojects O\nwith O\ncapacity O\nof O\n3,225 O\nmegawatt O\ngo O\non-line O\nby O\n1998/99 O\n. O\n\nTHE B-ORG\nNATION I-ORG\n\n- O\nThe O\ngovernment O\nis O\nfacing O\nextreme O\ndifficulties O\nin O\nmeeting O\nits O\nrevenue O\ncollections O\ntargets O\nfor O\n1996/97 O\n. O\n\n- O\nMohib B-ORG\nTextile I-ORG\nMills I-ORG\nhas O\ndefaulted O\nto O\nnearly O\n23 O\ndevelopment O\nfinance O\ninstitutions O\n, O\nforeign O\nand O\nlocal O\nbanks O\n, O\nleasing O\ncompanies O\nand O\nmodarabas O\n( O\nIslamic B-MISC\nmutual O\nfunds O\n) O\n. O\n\n- O\nInvestment O\nMinister O\nAsif B-PER\nAli I-PER\nZardari I-PER\nexpressed O\nkeenness O\nfor O\na O\nclose O\nworking O\nrelationship O\nwith O\nJapanese B-MISC\ncompanies O\nso O\nthat O\ninvestment O\nfrom O\nJapan B-LOC\ncan O\nmultiply.q O\n\n- O\nKarachi B-ORG\nStock I-ORG\nExchange I-ORG\nindex O\nfalls O\nby O\n7.84 O\npoints O\n. O\n\nTHE B-ORG\nNEWS I-ORG\n\n- O\nThe O\nprime O\nminister O\n's O\nspecial O\neconomic O\nassistant O\nShahid B-PER\nHasan I-PER\nKhan I-PER\nsaid O\nprivatisation O\nof O\nthermal O\npower O\nplants O\n, O\npower O\ngeneration O\nfrom O\nprivate O\nplants O\nand O\nmanagement O\ncontracts O\nof O\nArea B-MISC\nElectricity I-MISC\nBoards I-MISC\nwould O\nhelp O\nachieve O\n6.5 O\npercent O\nGDP O\ngrowth O\n. O\n\n- O\nPakistan B-LOC\n's O\nMuslim B-ORG\nCommercial I-ORG\nBank I-ORG\n, O\nVital B-ORG\nInformation I-ORG\nSystem I-ORG\n, O\nand O\nDuff B-ORG\nand I-ORG\nPhelps I-ORG\nof O\nthe O\nU.S. B-LOC\nare O\nlikely O\nto O\nannounce O\na O\nstrategic O\nalliance O\nwith O\nBangladesh B-LOC\n's O\nonly O\ncredit O\nrating O\ncompany O\n-- O\nCredit B-ORG\nRating I-ORG\nand I-ORG\nInformation I-ORG\nSystems I-ORG\nLtd I-ORG\n-- O\nnext O\nmonth O\n. O\n\n- O\nThe O\nSindh B-ORG\nHigh I-ORG\nCourt I-ORG\nissued O\nan O\nad-interim O\norder O\nrestraining O\nthe O\nPrivatisation B-ORG\nCommission I-ORG\nfrom O\nhanding O\nover O\nJavedan B-ORG\nCement I-ORG\nto O\nDadabhoy B-ORG\nInvestment I-ORG\n( I-ORG\npvt I-ORG\n) I-ORG\nLtd I-ORG\nuntil O\nit O\ncan O\nconsider O\na O\nlegal O\nchallenge O\nmounted O\nby O\nunions O\nto O\nthe O\ndeal O\n. O\n\nTHE B-ORG\nMUSLIM I-ORG\n\n- O\nPakistan B-LOC\nand O\nIran B-LOC\nhave O\nagreed O\nto O\nexpand O\nand O\nstrengthen O\npolitical O\n, O\ntrade O\nand O\neconomic O\nrelations O\n. O\n\n-- O\nIslamabad B-LOC\nnewsroom O\n9251-274757 O\n\n-DOCSTART- O\n\nSalang B-LOC\ntunnel O\nreopened O\nlinking O\nKabul B-LOC\nwith O\nnorth O\n. O\n\nSALANG B-LOC\nTUNNEL O\n, O\nAfghanistan B-LOC\n1996-08-29 O\n\nThe O\nSalang B-LOC\ntunnel O\nlinking O\nKabul B-LOC\nwith O\nnorthern O\nAfghanistan B-LOC\nwas O\nformally O\nreopened O\nto O\ntraffic O\non O\nThursday O\nunder O\nan O\nagreement O\nbetween O\nthe O\ngovernment O\nand O\nan O\nopposition O\nmilitia O\n, O\nwitnesses O\nsaid O\n. O\n\nThey O\nsaid O\ndozens O\nof O\ntrucks O\nbegan O\nmoving O\nthrough O\nthe O\ntunnel O\nfrom O\nboth O\ndirections O\nafter O\nthe O\nroad O\nreopened O\n. O\n\nThe O\nSalang B-LOC\ntunnel O\n, O\nthe O\nmain O\nsupply O\nroute O\nfor O\nSoviet B-MISC\ntroops O\nwhen O\nthey O\nwere O\noccupying O\nAfghanistan B-LOC\nin O\nthe O\n1980s O\n, O\nhad O\nbeen O\nclosed O\nsince O\n1994 O\nwhen O\nnorthern O\nmilitia O\nleader O\nGeneral O\nAbdul B-PER\nRashid I-PER\nDostum I-PER\nrebelled O\nagainst O\nthe O\nKabul B-LOC\ngovernment O\n. O\n\nWitnesses O\nsaid O\nwrecked O\ntanks O\nand O\nvehicles O\nlittered O\nboth O\nsides O\nof O\nthe O\nheavily-mined O\nroad O\n. O\n\nMines O\nhad O\nbeen O\nremoved O\nfrom O\nthe O\nroad O\nitself O\n, O\nbut O\nexperts O\nof O\nthe O\nHalo B-LOC\nTrust I-LOC\nmine O\nclearance O\nagency O\nsaid O\nit O\nwould O\ntake O\na O\nweek O\nto O\nclear O\nthe O\nroadsides O\n. O\n\nAfghan B-MISC\nDeputy O\nPrime O\nMinister O\nQotbuddin B-PER\nHilal I-PER\nofficiated O\nat O\nthe O\nreopening O\nceremony O\n, O\nwhich O\nwas O\ndelayed O\nby O\nseveral O\nhours O\nwhile O\nthe O\ntwo O\nsides O\nargued O\nabout O\na O\nmutual O\nrelease O\nof O\nprisoners O\n. O\n\n-DOCSTART- O\n\nTwo O\nIndians B-MISC\nto O\ndie O\nfor O\nkilling O\n23 O\nbus O\npassengers O\n. O\n\nNEW B-LOC\nDELHI I-LOC\n1996-08-29 O\n\nIndia B-LOC\n's O\nSupreme B-ORG\nCourt I-ORG\non O\nThursday O\nsentenced O\ntwo O\nmen O\nto O\ndeath O\nafter O\nfinding O\nthem O\nguilty O\nof O\nkilling O\n23 O\nbus O\npassengers O\n, O\nincluding O\nchildren O\n. O\n\nIt O\nsaid O\nthe O\ntwo O\n, O\nafter O\nrobbing O\nthe O\npassengers O\n, O\nburnt O\nthem O\nalive O\nby O\nsprinkling O\nthe O\nbus O\nwith O\npetrol O\nand O\nsetting O\nit O\non O\nfire O\nin O\nthe O\nsouthern O\nstate O\nof O\nAndhra B-LOC\nPradesh I-LOC\nin O\n1993 O\n. O\n\n\" O\nWe O\nhave O\nno O\ndoubt O\nthat O\nthis O\nis O\none O\nof O\nthe O\nrarest O\nof O\nthe O\nrare O\ncases O\n, O\nnot O\nmerely O\ndue O\nto O\nthe O\nnumber O\nof O\ninnocent O\nhuman O\nbeings O\nroasted O\nalive O\nby O\nthe O\nappellants O\n, O\nbut O\nthe O\ninhuman O\nmanner O\nin O\nwhich O\nthey O\nplotted O\nthe O\nscheme O\nand O\nexecuted O\nit O\n, O\n\" O\nJustice B-PER\nK.T. I-PER\nThomas I-PER\nsaid O\nin O\nthe O\nverdict O\nby O\na O\npanel O\nof O\nthree O\njudges O\n. O\n\n-DOCSTART- O\n\nElephant O\ntramples O\nwoman O\nto O\ndeath O\nin O\nNepal B-LOC\n. O\n\nKATHMANDU B-LOC\n1996-08-29 O\n\nA O\nrampaging O\nelephant O\ndragged O\na O\nsleeping O\n72-year-old O\nwoman O\nfrom O\nher O\nbed O\nand O\ntrampled O\nher O\nto O\ndeath O\nin O\nthe O\nthird O\nsuch O\nkilling O\nin O\ntwo O\nmonths O\n, O\nNepal B-LOC\npolice O\nsaid O\non O\nThursday O\n. O\n\nThe O\nelephant O\ncrashed O\ninto O\nHari B-PER\nMaya I-PER\nPoudels I-PER\nhouse O\nin O\nMadhumalla B-LOC\nvillage O\nearlier O\nthis O\nweek O\nwhile O\nshe O\nwas O\nasleep O\n, O\nthey O\nsaid O\n. O\n\nThe O\nbeast O\ndragged O\nthe O\nwoman O\n30 O\nfeet O\n( O\nnine O\nmetres O\n) O\naway O\nfrom O\nher O\nbed O\nand O\ntrampled O\nher O\nto O\ndeath O\n, O\na O\npolice O\nofficial O\ntold O\nReuters B-ORG\nin O\nthe O\nHimalayan B-MISC\nkingdoms O\ncapital O\nKathmandu B-LOC\n. O\n\nIn O\nthe O\npast O\ntwo O\nmonths O\nelephants O\nhave O\nkilled O\nthree O\npeople O\nin O\nremote O\nareas O\nof O\neast O\nand O\ncentral O\nNepal B-LOC\n. O\n\nElephants O\nare O\nprotected O\nunder O\nNepali B-MISC\nlaw O\n, O\nwhich O\nprovides O\nfor O\njail O\nsentences O\nof O\nup O\nto O\n15 O\nyears O\nfor O\nconvicted O\nelephant O\nkillers O\n. O\n\n-DOCSTART- O\n\nSri B-MISC\nLankan I-MISC\nrebels O\noverrun O\npolice O\npost O\n, O\nkill O\n24 O\n. O\n\nCOLOMBO B-LOC\n1996-08-29 O\n\nTamil B-ORG\nTiger I-ORG\nrebels O\noverran O\nan O\nisolated O\npolice O\npost O\nin O\nSri B-LOC\nLanka I-LOC\n's O\nnortheast O\nearly O\non O\nThursday O\nkilling O\n24 O\npolicemen O\n, O\ndefence O\nofficials O\nsaid O\n. O\n\nA O\nlarge O\ngroup O\nof O\nLiberation B-ORG\nTigers I-ORG\nof I-ORG\nTamil I-ORG\nEelam I-ORG\n( O\nLTTE B-ORG\n) O\nrebels O\nstormed O\nthe O\nKudapokuna B-LOC\npolice O\npost O\n, O\njust O\nnorth O\nof O\nWelikanda B-LOC\n, O\n200 O\nkm O\n( O\n125 O\nmiles O\n) O\nfrom O\nColombo B-LOC\n, O\nbefore O\ndawn O\n, O\nthey O\nsaid O\n. O\n\n\" O\nThe O\nentire O\npost O\nwas O\noverrun O\n, O\n\" O\nsaid O\na O\ndefence O\nofficial O\n. O\n\nIt O\nwas O\nnot O\nimmediately O\nclear O\nif O\nthere O\nwere O\nany O\ncasualties O\namong O\nthe O\nrebels O\n, O\nwho O\nare O\nfighting O\nfor O\nindependence O\nfor O\nminority O\nTamils B-MISC\nin O\nthe O\nIndian B-LOC\nOcean I-LOC\nisland O\n's O\nnorth O\nand O\neast O\n. O\n\nIt O\nis O\nthe O\nsecond O\ntime O\nin O\nthree O\ndays O\nthat O\nthe O\nrebels O\nattacked O\npolice O\n. O\n\nSuspected O\nTamil B-MISC\nTigers B-ORG\non O\nTuesday O\nhurled O\nhand O\ngrenades O\nat O\na O\npolice O\nvehicle O\nin O\na O\ncrowded O\nmarket O\nin O\nthe O\narmy-controlled O\nnorthern O\ntown O\nof O\nVavuniya B-LOC\n, O\nkilling O\nat O\nleast O\ntwo O\npolicemen O\n. O\n\nMore O\nthan O\na O\ndozen O\npeople O\n, O\nincluding O\nseveral O\npolice O\nwho O\nwere O\nworking O\nundercover O\n, O\nwere O\nwounded O\nin O\nthe O\nattack O\n. O\n\nVavuniya B-LOC\nis O\njust O\nsouth O\nof O\nthe O\nnorthern O\nmainland O\narea O\ncontrolled O\nby O\nthe O\nLTTE B-ORG\n. O\n\nThe O\ngovernment O\nsays O\nmore O\nthan O\n50,000 O\npeople O\nhave O\ndied O\nin O\nthe O\nethnic O\nwar O\n, O\nnow O\nin O\nits O\n14th O\nyear O\n. O\n\n-DOCSTART- O\n\nVicorp B-ORG\nRestaurants I-ORG\nnames O\nSabourin B-LOC\nCFO O\n. O\n\nDENVER B-PER\n1996-08-29 O\n\nVicorp B-ORG\nRestaurants I-ORG\nInc I-ORG\nsaid O\nit O\nhas O\nnamed O\nRichard B-PER\nSabourin I-PER\nas O\nexecutive O\nvice O\npresident O\nand O\nchief O\nfinancial O\nofficer O\n. O\n\nThe O\ncompany O\nsaid O\nSabourin B-PER\nis O\nthe O\nformer O\npresident O\nand O\nchief O\nexecutive O\nat O\nBestop B-ORG\nInc I-ORG\nof O\nBoulder B-LOC\n, O\nColo B-LOC\n. I-LOC\n\nIt O\nsaid O\nCraig B-PER\nHeld I-PER\nhas O\nalso O\njoined O\nthe O\ncompany O\nas O\nexecutive O\nvice O\npresident O\nand O\nchief O\nmarketing O\nofficer O\n. O\n\n-- O\nNew B-ORG\nYork I-ORG\nNewsdesk I-ORG\n212 O\n859 O\n1610 O\n\n-DOCSTART- O\n\nSoCal B-ORG\nEdison I-ORG\nsees O\n2 O\npower O\nlines O\nback O\ntoday O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nSouthern B-ORG\nCalifornia I-ORG\nEdison I-ORG\nCo I-ORG\nsaid O\nit O\nexpected O\ntwo O\n220 O\nkilovolt O\n( O\nKV O\n) O\npower O\nlines O\nin O\nsouthern O\nCalifornia B-LOC\nto O\nresume O\nservice O\nlater O\ntoday O\nafter O\nbeing O\nshut O\nlate O\nWednesday O\nbecause O\nof O\na O\nwildfire O\nraging O\nnorth O\nof O\nLos B-LOC\nAngeles I-LOC\n. O\n\n\" O\nThey O\nare O\nexpected O\nto O\nbe O\nplaced O\nin O\nservice O\nlater O\ntoday O\n, O\n\" O\nsaid O\ncompany O\nspokesman O\nSteve B-PER\nConroy I-PER\n, O\nadding O\nrepair O\ncrews O\nhave O\nbeen O\nremoving O\nsmoke O\nand O\nother O\nfire-related O\nresidues O\n, O\nwhich O\nhad O\nsettled O\non O\nthe O\ntwo O\nlines O\n. O\n\nThe O\nshutdown O\nof O\nthe O\n220 O\nKV O\nlines O\nreduced O\nby O\n500 O\nmegawatts O\n( O\nMW O\n) O\nthe O\namount O\nof O\npower O\nwhich O\nthe O\narea O\nreceived O\nfrom O\nSoCal B-ORG\nEdison I-ORG\n's O\n1,200 O\nMW O\nSierra B-LOC\nhydroelectric O\nfacility O\n, O\nhe O\nsaid O\n. O\n\nConroy B-PER\nnoted O\ntwo O\n500 O\nKV O\nand O\nanother O\n220 O\nKV O\nline O\nrunning O\nfrom O\nthe O\nSierra B-LOC\nplant O\nto O\nLos B-LOC\nAngeles I-LOC\nremained O\nin O\noperation O\n, O\nand O\ncontinued O\nto O\ncarry O\nsome O\nof O\nthe O\nproduction O\nfrom O\nSierra B-LOC\nto O\nthe O\nregion O\n. O\n\nOn O\nMonday O\n, O\nthe O\ntwo O\n500 O\nKV O\ntransmission O\ncables O\nwere O\ntaken O\nout O\nof O\nservice O\n, O\nalso O\nfor O\ncleaning O\n, O\nfor O\nabout O\na O\nday O\n. O\n\nContainment O\nof O\nthe O\nfire O\nhas O\nbeen O\ndifficult O\nbecause O\nof O\nthe O\nhot O\n, O\narid O\n, O\nwindy O\nweather O\nin O\nthe O\nregion O\n, O\nConroy B-PER\nsaid O\n. O\n\n\" O\nThe O\nfires O\nkeep O\nmoving O\nback O\nbecause O\nof O\nthe O\nwinds O\n, O\n\" O\nhe O\nsaid O\n, O\nforcing O\nthe O\nutility O\nto O\nshut O\nthose O\ntransmission O\nlines O\nfor O\na O\nsecond O\ntime O\nthis O\nweek O\n. O\n\nLocal O\nauthorities O\ncharged O\na O\nteenager O\nfor O\nstarting O\nthe O\nblaze O\n. O\n\nIn O\nfour O\ndays O\n, O\nthe O\nfire O\ndestroyed O\n20,000 O\nacres O\nof O\nforest O\nland O\n. O\n\n-- O\nR B-PER\nLeong I-PER\n, O\nNew B-ORG\nYork I-ORG\nPower I-ORG\nDesk I-ORG\n+1 O\n212 O\n859 O\n1622 O\n\n-DOCSTART- O\n\nDreyfus B-ORG\nStrategic I-ORG\nMunis I-ORG\nmonthly O\n$ O\n0.056 O\n/ O\nshr O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nMonthly O\n\nLatest O\nPrior O\n\nAmount O\n$ O\n0.056 O\n$ O\n0.056 O\n\nPay O\nSept O\n27 O\n\nRecord O\nSept O\n13 O\n\nNOTE O\n: O\nFull O\nname O\nof O\ncompany O\nis O\nDreyfus B-ORG\nStrategic I-ORG\nMunicipals I-ORG\nInc I-ORG\n. O\n\n-DOCSTART- O\n\nSierra B-ORG\nSemiconductor I-ORG\njumps O\non O\nexit O\nplan O\n. O\n\nMartin B-PER\nWolk I-PER\n\nSEATTLE B-LOC\n1996-08-29 O\n\nSierra B-ORG\nSemiconductor I-ORG\nCorp I-ORG\njumped O\n23 O\npercent O\nThursday O\non O\nthe O\nexpectation O\nthe O\ncompany O\nwould O\nemerge O\nas O\na O\nsmaller O\nbut O\nmore O\nprofitable O\noperation O\nafter O\nits O\nplanned O\nexit O\nfrom O\nthe O\ncomputer O\nmodem O\nbusiness O\n. O\n\nThe O\nSan B-LOC\nJose I-LOC\n, O\nCalif. B-LOC\n, O\ncompany O\nwas O\nup O\n2-1/8 O\nat O\n11-3/8 O\nafter O\nits O\nannouncement O\nWednesday O\nthat O\nit O\nplanned O\nto O\npull O\nout O\nof O\nthe O\nhighly O\ncompetitive O\nmodem-chip O\nbusiness O\nand O\nfocus O\ninstead O\non O\nthe O\nfast-growing O\nmarket O\nfor O\ncomputer O\nnetworking O\nequipment O\n. O\n\n\" O\nCertainly O\nthe O\ncompany O\nwill O\nbe O\na O\nmuch O\nsmaller O\ncompany O\nnow O\n, O\nbut O\nit O\nwill O\nbe O\na O\nmore O\nprofitable O\nbusiness O\n, O\n\" O\nsaid O\nanalyst O\nElias B-PER\nMoosa I-PER\nof O\nRoberston B-ORG\nStephens I-ORG\n& I-ORG\nCo I-ORG\n. O\n\nBut O\nanalysts O\nnoted O\nthat O\nSierra B-ORG\nstill O\nhas O\nmuch O\npainful O\nwork O\nahead O\nof O\nit O\n, O\nincluding O\ncutting O\nas O\nmany O\nas O\n150 O\njobs O\nfrom O\nits O\nworkforce O\n, O\nwhich O\ncurrently O\nhas O\n500 O\npeople O\n, O\nand O\nbuilding O\nup O\nthe O\nbusiness O\nof O\nits O\nPMC-Sierra B-ORG\nunit O\n, O\nwhich O\nmakes O\nrouting O\ndevices O\nand O\nchipsets O\nfor O\nhigh-speed O\ncomputer O\nnetworks O\n. O\n\nThe O\ncompany O\nhas O\nannounced O\nplans O\nto O\ntake O\na O\ncharge O\nagainst O\nearnings O\nof O\n$ O\n50 O\nmillion O\nto O\n$ O\n80 O\nmillion O\nto O\nwrite O\ndown O\nthe O\nvalue O\nof O\nassets O\nand O\ninventories O\nand O\ncover O\nseverance O\npayments O\n. O\n\nScott B-PER\nRandall I-PER\nof O\nSoundview B-ORG\nFinancial I-ORG\nGroup I-ORG\nsaid O\nthe O\ncompany O\nlikely O\nwould O\nhave O\ndifficulty O\nselling O\nits O\nmodem-chip O\nbusiness O\n. O\n\n\" O\nOnce O\nyou O\nannounce O\nyour O\nintention O\nto O\nexit O\na O\nbusiness O\n, O\nit O\nbecomes O\na O\ncomplete O\nbuyer O\n's O\nmarket O\n, O\n\" O\nhe O\nsaid O\n. O\n\nAnd O\nhe O\nsaid O\nthat O\nwhile O\nthe O\ncompany O\nis O\nfocusing O\non O\nthe O\nfastest-growing O\npart O\nof O\nits O\nbusiness O\n, O\nthe O\nmarket O\nfor O\nnetworking O\nchips O\nhas O\nbegun O\nto O\nattract O\nthe O\nattention O\nof O\nmuch-larger O\nplayers O\nsuch O\nas O\nInternational B-ORG\nBusiness I-ORG\nMachines I-ORG\nCorp I-ORG\n. O\n\n\" O\nAs O\nthe O\nmarket O\ndevelops O\nthe O\nquestion O\nis O\n, O\nare O\nthey O\nable O\nto O\nmake O\nthat O\ntransition O\nto O\nbe O\na O\nmuch O\nlarger O\ncompany O\n? O\n\" O\n\nRandall B-PER\nsaid O\n. O\n\nOther O\nanalysts O\nwere O\nmore O\nbullish O\n, O\neven O\nthough O\nthe O\ncompany O\nis O\nexpected O\nto O\nshrink O\nto O\nslightly O\nmore O\nthan O\nhalf O\nits O\ncurrent O\nsize O\nin O\nsales O\n. O\n\n\" O\nIt O\n's O\na O\npositive O\nstrategic O\nmove O\n, O\n\" O\nsaid O\nMiles B-PER\nKan I-PER\nof O\nHambrecht B-ORG\n& I-ORG\nQuist I-ORG\n. O\n\n\" O\nThe O\nmodem O\nbusiness O\nis O\na O\nlow-margin O\n, O\ncommodity O\nbusiness O\n, O\n\" O\nhe O\nsaid O\n. O\n\nThe O\ncompany O\n's O\nPMC-Sierra B-ORG\nunit O\ngenerated O\n$ O\n33 O\nmillion O\nof O\nthe O\ncompany O\n's O\n$ O\n117 O\nmillion O\nin O\nsales O\nin O\nthe O\nfirst O\nhalf O\nof O\nthe O\nyear O\n, O\ncompared O\nwith O\n$ O\n45 O\nmillion O\nin O\nsales O\nof O\nmodem O\nchips O\n, O\nKan B-PER\nsaid O\n. O\n\nBut O\nthe O\nPMC B-ORG\nunit O\nis O\nfar O\nmore O\nprofitable O\n, O\nhe O\nsaid O\n. O\n\nSierra B-ORG\n's O\nstock O\nhas O\nfallen O\nfrom O\na O\nhigh O\nof O\nnearly O\n$ O\n25 O\nthis O\nyear O\nas O\nthe O\ncomputer O\nchip O\nsector O\nhas O\nbeen O\nbattered O\nby O\nfalling O\nprices O\nand O\nconcern O\nabout O\nslowing O\ndemand O\n. O\n\n-- O\nSeattle B-LOC\nbureau O\n206-386-4848 O\n\n-DOCSTART- O\n\nHousecall B-ORG\nshares O\nsink O\nafter O\nprofit O\nwarning O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nShares O\nin O\nhome O\nhealthcare O\nservices O\ncompany O\nHousecall B-ORG\nMedical I-ORG\nResources I-ORG\nInc I-ORG\nfell O\nmore O\nthan O\n50 O\npercent O\non O\nThursday O\nafter O\nthe O\ncompany O\nsaid O\nit O\nexpected O\na O\nnet O\nloss O\nfor O\nthe O\nfiscal O\nfourth O\nquarter O\n. O\n\nMorgan B-ORG\nStanley I-ORG\nsaid O\nit O\ndowngraded O\nthe O\nstock O\nto O\nunderperform O\nfrom O\noutperform O\n. O\n\nHousecall B-ORG\nwas O\noff O\n7-3/8 O\nto O\n7-1/8 O\nin O\nmorning O\ntrading O\n. O\n\nThe O\nAtlanta-based B-MISC\ncompany O\nwent O\npublic O\nin O\nApril O\nat O\n$ O\n16 O\na O\nshare O\n. O\n\nWall B-LOC\nStreet I-LOC\nhad O\nexpected O\nthe O\ncompany O\nto O\nearn O\n$ O\n0.17 O\na O\nshare O\nin O\nits O\nfourth O\nquarter O\n, O\nended O\nJune O\n30 O\n, O\naccording O\nto O\nFirst O\nCall O\n. O\n\nHousecall B-ORG\nsaid O\nfourth O\nquarter O\nearnings O\nand O\nrevenues O\nwere O\nexpected O\nto O\nfall O\nshort O\nof O\nexpectations O\n. O\n\nIt O\nsaid O\nits O\nnon-Medicare B-MISC\ninfusion O\ntherapy O\n, O\nhospice O\nand O\nnursing O\nservices O\nbusinesses O\nfailed O\nto O\nmeet O\nbudgeted O\nrevenues O\n. O\n\nIt O\nalso O\ncited O\na O\nlimitation O\non O\nMedicare B-MISC\nreimbursement O\nfor O\nsome O\nservices O\nprovided O\nduring O\nthe O\nquarter O\n. O\n\n-DOCSTART- O\n\nFirst B-ORG\nAlliance I-ORG\nnet O\nincome O\nslips O\n. O\n\nIRVINE B-LOC\n, O\nCalif. B-LOC\n1996-08-29 O\n\nFirst B-ORG\nAlliance I-ORG\nCorporation I-ORG\nand I-ORG\nSubsidiaries I-ORG\n\nQuarter O\nended O\nJune O\n30 O\nSix O\nMonths O\nended O\nJune O\n30 O\n\n1996 O\n1995 O\n1996 O\n1995 O\n\nUnaudited O\n\nTotal O\nrevenue O\n\n17,024,000 O\n18,174,000 O\n31,834,000 O\n24,137,000 O\n\nTotal O\nexpense O\n\n7,718,000 O\n6,828,000 O\n14,668,000 O\n13,091,000 O\n\nNet O\nIncome O\n9,167,000 O\n11,175,000 O\n16,909,000 O\n10,880,000 O\n\nNet O\nIncome O\nPer O\n\nShare O\n0.86 O\n1.05 O\n1.59 O\n1.02 O\n\nWeighted O\naverage O\nnumber O\nof O\n\nshares O\noutstanding O\n\n10,650,407 O\n10,650,407 O\n10,650,407 O\n10,650,407 O\n\nPro O\nForma O\n: O\n\nHistorical O\nincome O\nbefore O\nincome O\n\ntax O\nprovision O\n\n9,306,000 O\n11,346,000 O\n17,166,000 O\n11,046,000 O\n\nPro O\nforma O\nincome O\ntax O\n\nprovision O\n3,820,000 O\n4,658,000 O\n7,047,000 O\n4,534,000 O\n\nPro O\nforma O\nnet O\n\nincome O\n5,486,000 O\n6,688,000 O\n10,119,000 O\n6,512,000 O\n\nPro O\nforma O\nnet O\nincome O\n\nper O\nshare O\n0.37 O\n0.45 O\n0.68 O\n0.44 O\n\nPro O\nforma O\nweighted O\naverage O\n\nnumber O\nof O\nshares O\n\noutstanding O\n14,775,000 O\n14,775,000 O\n14,775,000 O\n14,775,000 O\n\n-DOCSTART- O\n\nOasis B-ORG\nsinger O\nheads O\nfor O\nU.S. B-LOC\nafter O\nillness O\n. O\n\nLONDON B-LOC\n1996-08-29 O\n\nLiam B-PER\nGallagher I-PER\n, O\nsinger O\nof O\nBritain B-LOC\n's O\ntop O\nrock O\ngroup O\nOasis B-ORG\n, O\nflew O\nout O\non O\nThursday O\nto O\njoin O\nthe O\nband O\nthree O\ndays O\nafter O\nthe O\nstart O\nof O\nits O\nU.S. B-LOC\ntour O\n. O\n\nGallagher B-PER\nmade O\nhis O\nusual O\nobscene O\ngestures O\nand O\nswore O\nat O\njournalists O\nas O\nhe O\nprepared O\nto O\nfly O\nfrom O\nLondon B-LOC\n's O\nHeathrow B-LOC\nairport O\nto O\nChicago B-LOC\n. O\n\n\" O\nI O\nhate O\nyou O\nf... O\ning O\nlot O\n, O\nyet O\nyou O\n're O\nalways O\nasking O\nme O\ntoo O\nmany O\nthings O\n. O\n\nI O\n'm O\nnot O\na O\nsupermodel O\nyou O\nknow O\n, O\n\" O\nhe O\nsaid O\n. O\n\nOn O\nMonday O\n, O\njust O\n15 O\nminutes O\nbefore O\nhis O\nflight O\nwas O\ndue O\nto O\ndepart O\n, O\nLiam B-PER\ndecided O\nnot O\nto O\ntravel O\nwith O\nthe O\nrest O\nof O\nthe O\ngroup O\n, O\nwhich O\nincludes O\nhis O\nbrother O\nNoel B-PER\n. O\n\nLiam B-PER\ncaught O\na O\ntaxi O\nback O\nto O\nLondon B-LOC\nsaying O\nhe O\nhad O\n\" O\nproblems O\nat O\nhome O\n\" O\n. O\n\nHe O\nwas O\nbelieved O\nto O\nbe O\nsuffering O\nfrom O\nlaryngitis O\nand O\nsaid O\nhe O\nhad O\nto O\ngo O\nhouse-hunting O\nwith O\nactress O\ngirlfriend O\nPatsy B-PER\nKensit I-PER\n. O\n\nWhen O\nthey O\nfirst O\nheard O\nthat O\nLiam B-PER\nhad O\nnot O\nflown O\nout O\nwith O\nthe O\nband O\nat O\nthe O\nstart O\nof O\nthe O\ntour O\n, O\nmany O\nU.S. B-LOC\nfans O\nasked O\nfor O\nrefunds O\non O\ntheir O\nconcert O\ntickets O\n. O\n\nThe O\ngroup O\nbegan O\nthe O\nU.S. B-LOC\ntour O\n, O\nwhich O\nis O\nscheduled O\nto O\nlast O\nuntil O\nSeptember O\n18 O\n, O\nwith O\na O\nconcert O\nin O\nChicago B-LOC\non O\nTuesday O\nat O\nwhich O\nNoel B-PER\nGallagher I-PER\nfilled O\nin O\nfor O\nhis O\nbrother O\nas O\nlead O\nsinger O\n. O\n\n-DOCSTART- O\n\nSlough B-ORG\nEstates I-ORG\nhelps O\nlift O\nproperty O\nsector O\n. O\n\nLONDON B-LOC\n1996-08-29 O\n\nA O\nstrong O\nset O\nof O\ninterim O\nresults O\nand O\nan O\nupbeat O\noutlook O\nfrom O\nSlough B-ORG\nEstates I-ORG\nPlc I-ORG\nhelped O\nto O\nboost O\nthe O\nproperty O\nsector O\non O\nThursday O\n. O\n\nShares O\nin O\nSlough B-ORG\n, O\nwhich O\nearlier O\nannounced O\na O\n14 O\npercent O\nrise O\nin O\nfirst-half O\npretax O\nprofit O\nto O\n37.4 O\nmillion O\nstg O\n, O\nclimbed O\nnearly O\nsix O\npercent O\n, O\nor O\n14p O\nto O\n250 O\npence O\nat O\n1009 O\nGMT B-MISC\n, O\nwhile O\nBritish B-ORG\nLand I-ORG\nadded O\n12-1 O\n/ O\n2p O\nto O\n468p O\n, O\nLand B-ORG\nSecurities I-ORG\nrose O\n5-1 O\n/ O\n2p O\nto O\n691p O\nand O\nHammerson B-ORG\nwas O\n8p O\nhigher O\nat O\n390 O\n. O\n\nTraders O\nsaid O\npositive O\ncomment O\nfrom O\ninvestment O\nbanks O\nMerrill B-ORG\nLynch I-ORG\nand O\nSBC B-ORG\nWarburg I-ORG\nalso O\nfueled O\nthe O\ngains O\n. O\n\nOne O\ndealer O\nsaid O\npositive O\nstances O\nfrom O\nMerrill B-ORG\nLynch I-ORG\nand O\nSBC B-ORG\nWarburg I-ORG\nwere O\nthe O\nkey O\nfactors O\nbehind O\nthe O\ngains O\n. O\n\nA O\nspokesman O\nfor O\nMerrill B-ORG\nLynch I-ORG\nsaid O\nthe O\nbank O\nwas O\npreparing O\nto O\nissue O\na O\nnote O\non O\nthe O\nsector O\n. O\n\" O\n\nWe O\nhave O\nbeen O\nvery O\npositive O\n( O\non O\nproperty O\n) O\n, O\n\" O\nhe O\nsaid O\n, O\nadding O\n: O\n\" O\nOn O\na O\ntechnical O\nbasis O\nit O\nis O\nour O\nmost O\nfavoured O\nsector O\n. O\n\" O\n\nSBC B-ORG\nWarburg I-ORG\nissued O\nan O\nupdate O\non O\nthe O\nproperty O\nsector O\non O\nThursday O\n, O\nsaying O\nthat O\nmost O\nof O\nthe O\npredictions O\nit O\nmade O\nat O\nthe O\nstart O\nof O\nthe O\nyear O\nwere O\nbeing O\nrealised O\n. O\n\n\" O\nIn O\nthe O\nproperty O\nmarket O\nit O\nis O\na O\ncase O\nof O\nso O\nfar O\n, O\nso O\ngood O\n, O\n\" O\na O\nmember O\nof O\nSBC B-ORG\nWarburg I-ORG\n's O\nproperty O\nteam O\nsaid O\n. O\n\nSBC B-ORG\nWarburg I-ORG\nsaid O\nit O\nis O\nmaintaining O\nits O\nforecast O\nfor O\nfive O\npercent O\ngrowth O\nin O\nrental O\nincomes O\nduring O\n1996 O\n, O\nbut O\nit O\nhas O\nshaved O\nits O\nforecast O\nfor O\ncapital O\ngrowth O\nto O\nfive O\npercent O\nfrom O\nsix O\n. O\n\nThe O\nspokesman O\nsaid O\nSBC B-ORG\nWarburg I-ORG\nhas O\nalso O\nput O\nan O\n\" O\nadd O\n\" O\nrecommendation O\non O\nSlough B-ORG\nEstates I-ORG\n' O\nshares O\n, O\nbut O\nadded O\nthat O\nthis O\n\" O\nis O\na O\ngeneral O\nmove O\n, O\nnot O\nbecause O\nof O\nthe O\nresults O\n. O\n\" O\n\nSlough B-ORG\n's O\nchairman O\nSir O\nNigel B-PER\nMobbs I-PER\nadded O\nto O\nthe O\nbullish O\nmood O\nin O\nthe O\nsector O\n, O\nsaying O\nin O\na O\nstatement O\nthat O\n\" O\nwith O\nthe O\nprospect O\nof O\na O\nperiod O\nof O\nsteady O\neconomic O\ngrowth O\nand O\nlow O\ninflation O\nahead O\n, O\nthere O\nis O\ngood O\nreason O\nto O\nbelieve O\nthat O\nthe O\nproperty O\nsector O\nshould O\ncontinue O\nits O\nimprovement O\n. O\n\" O\n\n-- O\nJonathan B-PER\nBirt I-PER\n, O\nLondon B-ORG\nNewsroom I-ORG\n+44 O\n171 O\n542 O\n7717 O\n\n-DOCSTART- O\n\nCanada B-LOC\n's O\ninternational O\ntravel O\naccount O\ngap O\nshrinks O\n. O\n\nOTTAWA B-LOC\n1996-08-29 O\n\nHigher O\nspending O\nby O\nforeign O\nvisitors O\nand O\nless O\nCanadian B-MISC\ntourist O\nspending O\nabroad O\ncut O\nthe O\ndeficit O\nin O\nCanada B-LOC\n's O\ninternational O\ntravel O\naccount O\nby O\n26.5 O\npercent O\nin O\nthe O\nsecond O\nquarter O\n, O\nStatistics B-ORG\nCanada I-ORG\nsaid O\non O\nThursday O\n. O\n\nThe O\ndeficit O\nfell O\nto O\na O\nseasonally O\nadjusted O\nC$ B-MISC\n715 O\nmillion O\nin O\nthe O\nsecond O\nquarter O\nfrom O\nC$ B-MISC\n973 O\nmillion O\nin O\nthe O\nfirst O\n, O\nas O\nforeigners O\nspent O\na O\nrecord O\nC$ B-MISC\n3.00 O\nbillion O\nseasonally O\nadjusted O\nwhile O\nCanadians B-MISC\nreduced O\ntheir O\nspending O\nabroad O\nby O\n5.1 O\npercent O\nto O\nC$ B-MISC\n3.72 O\nbillion O\n. O\n\n-- O\nReuters B-ORG\nOttawa I-ORG\nBurea I-ORG\n( O\n613 O\n) O\n235-6745 O\n\n-DOCSTART- O\n\nJordanian B-MISC\nPM O\nKabariti B-PER\nmeets O\nArafat B-PER\nin O\nWest B-LOC\nBank I-LOC\n. O\n\nRAMALLAH B-LOC\n, O\nWest B-LOC\nBank I-LOC\n1996-08-29 O\n\nJordanian B-MISC\nPrime O\nMinister O\nAbdul-Karim B-PER\nal-Kabariti I-PER\nbegan O\ntalks O\nwith O\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\nin O\nthe O\nWest B-LOC\nBank I-LOC\non O\nThursday O\non O\nthe O\nstalled O\nMiddle B-LOC\nEast I-LOC\npeace O\nprocess O\n, O\nofficials O\nsaid O\n. O\n\nKabariti B-PER\nflew O\nby O\nhelicopter O\nto O\nPalestinian-ruled B-MISC\nRamallah B-LOC\nand O\nafter O\na O\nbrief O\narrival O\nceremony O\nwent O\ninto O\ntalks O\nwith O\nArafat B-PER\n. O\n\nThe O\nprime O\nminister O\n's O\nvisit O\n, O\nhis O\nfirst O\ntrip O\noutside O\nthe O\ncountry O\nsince O\nJordan B-LOC\nwas O\nshaken O\nby O\nfood O\nriots O\nearlier O\nthis O\nmonth O\n, O\ncame O\nagainst O\nthe O\nbackdrop O\nof O\na O\nPalestinian B-MISC\ngeneral O\nstrike O\nin O\nthe O\nWest B-LOC\nBank I-LOC\nand O\nGaza B-LOC\n. O\n\nArafat B-PER\ncalled O\nthe O\nfour-hour O\nstrike O\n, O\nwhich O\nended O\nat O\nnoon O\n( O\n0900 O\nGMT B-MISC\n) O\nto O\nprotest O\nagainst O\nIsraeli B-MISC\npolicy O\non O\nsettlements O\nand O\nJerusalem B-LOC\n. O\n\nJordan B-LOC\n's O\nofficial O\nstate O\nnews O\nagency O\nPetra B-ORG\nsaid O\nKabariti B-PER\nwould O\nhold O\ndiscussions O\n\" O\non O\nthe O\nlatest O\ndevelopments O\nin O\nthe O\npeace O\nprocess O\nand O\nbilateral O\ncooperation O\n\" O\n. O\n\n-DOCSTART- O\n\nIran B-LOC\nsays O\nfive O\nspy O\nnetworks O\ndestroyed O\n, O\n41 O\nheld O\n. O\n\nTEHRAN B-LOC\n1996-08-29 O\n\nIranian B-MISC\nsecurity O\nforces O\nhave O\nbroken O\nup O\nfive O\nespionage O\nrings O\nin O\nnorthwestern O\nIran B-LOC\nand O\narrested O\n41 O\npeople O\non O\ncharges O\nof O\nspying O\nfor O\nunnamed O\ncountries O\n, O\na O\ndaily O\nnewspaper O\nsaid O\non O\nThursday O\n. O\n\nJomhuri B-ORG\nEslami I-ORG\nquoted O\nthe O\nWest B-LOC\nAzerbaijan I-LOC\nprovince O\nsecurity O\nchief O\nas O\nsaying O\nthose O\nheld O\nconfessed O\nto O\ngathering O\nconfidential O\ninformation O\n, O\nphotographing O\nstrategic O\nsites O\n, O\ndoing O\npropaganda O\nagainst O\nstate O\nofficials O\nand O\n\" O\nspreading O\npan-Turkism B-MISC\n\" O\n. O\n\nIt O\nwas O\nnot O\nclear O\nif O\nthey O\nwere O\nthe O\nsame O\nfive O\nspy O\nrings O\n, O\nallegedly O\nled O\nby O\nTurkish B-MISC\ndiplomats O\n, O\nthat O\nIran B-LOC\nsaid O\nin O\nApril O\nit O\nhad O\nbroken O\nup O\nin O\nthe O\nsame O\narea O\n, O\nwhich O\nborders O\nTurkey B-LOC\n. O\n\nThe O\nApril O\narrests O\nwere O\nannounced O\nshortly O\nafter O\na O\nrow O\nin O\nwhich O\nTehran B-LOC\nasked O\nAnkara B-LOC\nto O\nwithdraw O\nfour O\nTurkish B-MISC\ndiplomats O\naccused O\nof O\nspying O\n, O\nand O\nTurkey B-LOC\nexpelled O\nfour O\nIranian B-MISC\ndiplomats O\nfor O\ntheir O\nalleged O\nlinks O\nto O\nkillings O\nof O\nIranian B-MISC\nexiles O\n. O\n\nTies O\nbetween O\nthe O\ntwo O\nneighbours O\n, O\nstrained O\nalso O\nover O\na O\nmilitary O\naccord O\nbetween O\nTurkey B-LOC\nand O\nIsrael B-LOC\nwhich O\ndrew O\nstrong O\nIranian B-MISC\nobjections O\n, O\nhave O\nimproved O\nsince O\nIslamist B-MISC\nNecmettin B-PER\nErbakan I-PER\ntook O\nover O\nas O\nTurkish B-MISC\nprime O\nminister O\nin O\nJune O\n. O\n\nThe O\ndaily O\nIran B-LOC\non O\nThursday O\nquoted O\nIntelligence O\nMinister O\nAli B-PER\nFallahiyan I-PER\nas O\nsaying O\nagents O\narrested O\n137 O\npeople O\nfor O\nallegedly O\nspying O\nfor O\nIraq B-LOC\n, O\nthe O\nUnited B-LOC\nStates I-LOC\nand O\nother O\nunnamed O\ncountries O\nin O\nthe O\nIranian B-MISC\nyear O\nwhich O\nended O\non O\nMarch O\n19 O\n. O\n\n-DOCSTART- O\n\nMideast B-LOC\nGulf I-LOC\noil O\noutlook O\n- O\nIndia B-LOC\nholds O\nthe O\nkey O\n. O\n\nDUBAI B-LOC\n1996-08-29 O\n\nIndia B-LOC\nwill O\ncontinue O\nto O\nhold O\nthe O\nkey O\nto O\nthe O\nmiddle O\ndistillates O\nproduct O\nmarket O\nin O\nthe O\nMiddle B-LOC\nEast I-LOC\nGulf I-LOC\nin O\nthe O\nshort O\nterm O\n, O\ntraders O\nin O\nthe O\nregion O\nsaid O\non O\nThursday O\n. O\n\nThey O\nsaid O\npremiums O\non O\nhigh O\nquality O\njet O\nkerosene O\nhave O\nwidened O\nto O\naround O\n$ O\n1 O\n, O\nand O\nare O\nlikely O\nto O\nremain O\nstrong O\nin O\nthe O\nnear O\nterm O\n. O\n\n\" O\nOn O\nthe O\njet O\nkerosene O\nside O\nwe O\nmust O\nbe O\ncautious O\nabout O\nquality O\n. O\n\nSome O\nare O\ncommanding O\na O\nvery O\ngood O\npremium O\nof O\n95 O\ncents O\nto O\none O\ndollar O\n. O\n\nIt O\n's O\nbeen O\n99 O\ncents O\nto O\nKorea B-LOC\n. O\n\nThis O\nwill O\nstay O\nat O\nthis O\nsort O\nof O\nprice O\npremium O\nfor O\na O\nwhile O\n, O\n\" O\none O\nsaid O\n. O\n\n\" O\nBut O\nfor O\nnormal O\njet O\nthe O\nweakened O\ndemand O\nis O\nquite O\nnoticeable O\n, O\nthe O\npremium O\nis O\naround O\n45-50 O\ncents O\n. O\n\nThe O\ndifferential O\nis O\nnot O\nnormally O\nas O\nwide O\nas O\nthis O\n, O\n\" O\nhe O\nadded O\n. O\n\nAnother O\nput O\nthe O\npremium O\nfor O\njet O\nkerosene O\nat O\nbetween O\n65 O\nand O\n75 O\ncents O\n. O\n\nOne O\ntrader O\nsaid O\ndespite O\nthe O\nfact O\nthat O\nsome O\nkerosene O\nwas O\nin O\nstorage O\nat O\nDubai B-LOC\nports O\n, O\ndemand O\nlooked O\nto O\nexceed O\nsupply O\nin O\nthe O\nnear O\nterm O\n. O\n\nJet O\nkerosene O\nwas O\nassessed O\nat O\n$ O\n27.40 O\n- O\n$ O\n27.70 O\na O\nbarrel O\nfob O\nGulf B-LOC\non O\nThursday O\n, O\nup O\nfrom O\n$ O\n27.22 O\nlast O\nweek O\n. O\n\nDealers O\nexpected O\npremiums O\nto O\nstick O\naround O\ncurrent O\nlevels O\nfor O\nthe O\nnext O\ntwo O\nor O\nthree O\nweeks O\n, O\nbefore O\nthey O\nget O\na O\nboost O\nin O\nthe O\nsecond O\nhalf O\nof O\nSeptember O\nfrom O\ndemand O\nfor O\nOctober O\ncargoes O\n. O\n\nGas O\noil O\n, O\nassessed O\nat O\n$ O\n24.00 O\n- O\n$ O\n24.20 O\na O\nbarrel O\nfob O\nGulf B-LOC\n, O\nwas O\nlittle O\nchanged O\non O\nThursday O\nfrom O\nlast O\nweek O\n's O\n$ O\n24.10 O\n- O\n$ O\n24.24 O\n. O\n\n\" O\nOn O\ngas O\noil O\n, O\nin O\nthe O\nnear O\nterm O\ndemand O\nand O\nsupply O\nare O\nbalanced O\nto O\na O\nbit O\nshort O\n, O\nthere O\nare O\nsome O\nenquiries O\ninto O\neast O\nAfrica B-LOC\nand O\nshort O\ncovering O\nin O\nIndia B-LOC\n, O\n\" O\nsaid O\none O\ntrader O\n. O\n\n\" O\nThe O\nIndians B-MISC\nhave O\nawarded O\nthree O\ncargoes O\n, O\nbut O\nthe O\nquestion O\nis O\nwhether O\nthey O\nwill O\ncome O\nout O\nfor O\nmore O\n, O\n\" O\nhe O\nadded O\n. O\n\nIndia B-LOC\nhas O\nacquired O\n120,000 O\ntonnes O\nof O\ndiesel O\nin O\nthree O\ncargoes O\n, O\nbound O\nfor O\nthe O\nwest O\ncoast O\n, O\nin O\nits O\nOctober O\ntender O\n. O\n\nTraders O\nsaid O\nthe O\naward O\ncould O\nbe O\nIndia B-LOC\n's O\nlowest O\nin O\nrecent O\nyears O\n. O\n\n\" O\nAfter O\nIOC B-ORG\n's O\nvery O\nsmall O\npurchase O\nof O\n120,000 O\ntonnes O\n, O\nI O\n'm O\nstill O\nsuspicious O\nthat O\nthey O\nwill O\nbuy O\nmore O\nin O\nthe O\nsecond O\nhalf O\nof O\nOctober O\n, O\n\" O\nanother O\nsaid O\n. O\n\nBut O\ntraders O\nsee O\nthe O\nmarket O\nremaining O\ntight O\nin O\nthe O\nshort-term O\n, O\nwith O\nsome O\nsurplus O\narising O\ncloser O\nto O\nOctober O\n. O\n\n\" O\nI O\nsee O\nan O\noverhang O\nof O\ngas O\noil O\nfurther O\nout O\n, O\n\" O\none O\nsaid O\n. O\n\n\" O\nGas O\noil O\nwill O\nremain O\ntight O\nin O\nthe O\nshort O\nterm O\nup O\nto O\nmid-September O\nwith O\nthe O\npremium O\nof O\naround O\n$ O\n1 O\nfor O\n0.5 O\npercent O\n( O\nsulphur O\nmaterial O\n) O\n. O\n\nIn O\nthe O\nsecond O\nhalf O\nof O\nSeptember O\nand O\nOctober O\nwe O\nsee O\nthe O\npremium O\ncoming O\noff O\nto O\n70-75 O\ncents O\n. O\n\" O\n\nTraders O\nsaid O\nthere O\nwas O\nnot O\nmuch O\ndemand O\nfor O\none O\npercent O\nsulphur O\nmaterial O\ngas O\noil O\n, O\nwith O\nthe O\npremium O\nat O\n40 O\nto O\n45 O\ncents O\n. O\n\n-DOCSTART- O\n\nEgypt B-LOC\npolice O\ncatch O\nancient O\nmanuscript O\nthieves O\n. O\n\nCAIRO B-LOC\n1996-08-29 O\n\nEgyptian B-MISC\npolice O\nhave O\narrested O\neight O\npeople O\nwho O\nwere O\ntrying O\nto O\nsell O\nan O\nancient O\ncopy O\nof O\nthe O\nOld B-MISC\nTestament I-MISC\n, O\nthe O\nofficial O\nal-Akhbar B-ORG\nnewspaper O\nsaid O\non O\nThursday O\n. O\n\nThe O\ndaily O\nsaid O\nthe O\nmen O\nhad O\nwanted O\nto O\nsell O\nthe O\nundated O\nmanuscript O\nto O\na O\nJewish B-MISC\ngroup O\nfor O\nfive O\nmillion O\npounds O\n( O\n$ O\n1.5 O\nmillion O\n) O\n. O\n\nInstead O\nan O\nundercover O\npolice O\nofficer O\npretended O\nto O\nbe O\ninterested O\nin O\nbuying O\nit O\nand O\narrested O\nthem O\n. O\n\nThe O\nnewspaper O\ndid O\nnot O\ngive O\nany O\ndetails O\nabout O\nthe O\nmanuscript O\nbut O\nsaid O\nit O\nhad O\nbeen O\nrelinquished O\nto O\nthe O\nIslamic B-LOC\nMuseum I-LOC\nin O\nCairo B-LOC\n. O\n\n-DOCSTART- O\n\nNew O\nU.S. B-LOC\nambassador O\narrives O\nin O\nSaudi B-LOC\nArabia I-LOC\n. O\n\nDUBAI B-LOC\n1996-08-29 O\n\nWashington B-LOC\n's O\nnew O\nambassador O\nto O\nSaudi B-LOC\nArabia I-LOC\n, O\nWyche O\nFowler B-PER\n, O\narrived O\nin O\nthe O\nkingdom O\nto O\ntake O\nup O\nhis O\npost O\n, O\nthe O\nU.S. B-LOC\nembassy O\nin O\nRiyadh B-LOC\nsaid O\non O\nThursday O\n. O\n\nFowler B-PER\n, O\na O\nlawyer O\nand O\nformer O\nsenator O\n, O\narrived O\nlate O\non O\nWednesday O\n, O\nthe O\nembassy O\nsaid O\nin O\na O\nstatement O\n. O\n\nPresident O\nBill B-PER\nClinton I-PER\nearlier O\nthis O\nmonth O\ninvoked O\nspecial O\npowers O\nto O\nappoint O\nFowler B-PER\nduring O\nthe O\ncongressional O\nrecess O\nbecause O\nthe O\nSenate B-ORG\ndelayed O\nconfirming O\nhis O\nnomination O\n. O\n\nFowler B-PER\n's O\npredecessor O\nRaymond B-PER\nMabus I-PER\nreturned O\nto O\nthe O\nUnited B-LOC\nStates I-LOC\nin O\nMay O\n. O\n\n-DOCSTART- O\n\nJordanian B-MISC\nPM O\nKabariti B-PER\nleaves O\nfor O\nWest B-LOC\nBank I-LOC\n. O\n\nAMMAN B-LOC\n1996-08-29 O\n\nJordanian B-MISC\nPrime O\nMinister O\nAbdul-Karim B-PER\nal-Kabariti I-PER\nleft O\nAmman B-LOC\non O\nThursday O\nfor O\nthe O\nWest B-LOC\nBank I-LOC\ntown O\nof O\nRamallah B-LOC\nto O\nhold O\ntalks O\nwith O\nPalestinian B-MISC\nPresident O\nYasser B-PER\nArafat I-PER\non O\nthe O\nstalled O\nMiddle B-LOC\nEast I-LOC\npeace O\nprocess O\n, O\nofficials O\nsaid O\n. O\n\nThe O\nofficial O\nstate O\nnews O\nagency O\nPetra B-ORG\nsaid O\nKabariti B-PER\nwould O\nhold O\ndiscussions O\n\" O\non O\nthe O\nlatest O\ndevelopments O\nin O\nthe O\npeace O\nprocess O\nand O\nbilateral O\ncooperation O\n\" O\n. O\n\nThe O\nvisit O\nwas O\nKabariti B-PER\n's O\nfirst O\ntrip O\noutside O\nthe O\ncountry O\nsince O\nJordan B-LOC\nwas O\nshaken O\nby O\nfood O\nriots O\nearlier O\nthis O\nmonth O\n. O\n\n-DOCSTART- O\n\nPalestinians B-MISC\nend O\nfour-hour O\nstrike O\n. O\n\nJERUSALEM B-LOC\n1996-08-29 O\n\nPalestinians B-MISC\nreopened O\ntheir O\nshops O\non O\nThursday O\nat O\nthe O\nend O\nof O\na O\nfour-hour O\nstrike O\ncalled O\nby O\nPresident O\nYasser B-PER\nArafat I-PER\nto O\nprotest O\nagainst O\nIsrael B-LOC\n's O\npolicy O\non O\nJewish B-MISC\nsettlements O\nand O\nJerusalem B-LOC\n, O\nwitnesses O\nsaid O\n. O\n\nShopkeepers O\nin O\nArab B-LOC\nEast I-LOC\nJerusalem I-LOC\nrolled O\nup O\ntheir O\nshutters O\nsome O\n10 O\nminutes O\nbefore O\nthe O\nscheduled O\nnoon O\n( O\n0900 O\nGMT B-MISC\n) O\nend O\nof O\nthe O\nstoppage O\n. O\n\nPalestinian B-MISC\nleaders O\ncalled O\nthe O\nstrike O\n, O\nthe O\nfirst O\nin O\nthe O\nWest B-LOC\nBank I-LOC\nand O\nGaza B-LOC\nsince O\n1994 O\n, O\na O\nwarning O\nsignal O\nthat O\nthe O\npeace O\nprocess O\nwith O\nIsrael B-LOC\nwas O\nin O\ndanger O\n. O\n\nWitnesses O\nsaid O\nmost O\nshops O\nwere O\nclosed O\nin O\ntowns O\nand O\nvillages O\nin O\nthe O\nareas O\n, O\nwith O\nthe O\nexception O\nof O\nHebron B-LOC\n, O\na O\nWest B-LOC\nBank I-LOC\ncity O\nstill O\nunder O\nIsraeli B-MISC\noccupation O\n. O\n\n-DOCSTART- O\n\nU.S. B-LOC\nwheat O\nweekly O\nexport O\nsales O\nhighlights O\n- O\nUSDA B-ORG\n. O\n\nWASHINGTON B-LOC\n1996-08-29 O\n\nU.S. B-LOC\nwheat O\nmajor O\nnet O\nsales O\nactivity O\nin O\nthe O\nweek O\nended O\nAug O\n22 O\nreported O\nby O\nexporters O\nfor O\nthe O\nfollowing O\npurchasing O\ncountries O\n, O\nin O\ntonnes O\n: O\n\nNet O\nSales O\n: O\n1996/97 O\n1997/98 O\n\nEgypt B-LOC\n199,900 O\nNil O\n\nS. B-LOC\nKorea I-LOC\n149,100-A O\n\nJapan B-LOC\n74,600 O\n\nChina B-LOC\n55,000-B O\n\nIndonesia B-LOC\n55,000-B O\n\nUnknown O\n- O\n161,600 O\n\nA- O\nincludes O\n54,600 O\ntonnes O\nchanged O\nfrom O\nunknown O\n. O\n\nB- O\nreflects O\n55,000 O\ntonnes O\nchanged O\nfrom O\nunknown O\n. O\n\nPrimary O\nExport O\nDestinations O\n: O\nEgypt B-LOC\n, O\nMorocco B-LOC\n, O\nS. B-LOC\nKorea I-LOC\n, O\nYemen B-LOC\n, O\nPakistan B-LOC\n, O\nMexico B-LOC\nand O\nChina B-LOC\n. O\n\n-DOCSTART- O\n\nKeane B-ORG\nwins O\ncontract O\nfrom O\nING B-ORG\nunits O\n. O\n\nBOSTON B-LOC\n1996-08-29 O\n\nSoftware O\nservices O\ncompany O\nKeane B-ORG\nInc I-ORG\nsaid O\nit O\nhad O\nwon O\na O\nyear O\n2000 O\ncompliance O\ncontract O\nfrom O\nLife B-ORG\nInsurance I-ORG\nCo I-ORG\nof I-ORG\nGeorgia I-ORG\nand O\nSouthland B-ORG\nLife I-ORG\nInsurance I-ORG\nCo I-ORG\n, O\nboth O\npart O\nof O\nThe B-LOC\nNetherlands I-LOC\n' O\nING B-ORG\nGroup I-ORG\n. O\n\nThe O\ncompany O\nsaid O\nin O\na O\nstatement O\nlate O\non O\nWednesday O\nit O\nwould O\nconduct O\nan O\nenterprise O\nassessment O\nand O\nstrategic O\ncompliance O\nplan O\nfor O\npreparing O\nall O\nthe O\nmainframe O\nsystems O\nof O\nLife B-ORG\nof I-ORG\nGeorgia I-ORG\nand O\nSouthland B-ORG\nLife I-ORG\nto O\noperate O\nin O\nthe O\nnew O\ncentury O\n. O\n\nThe O\nproject O\nwill O\nbe O\nmanaged O\nby O\nKeane B-ORG\n's O\nAtlanta B-LOC\noffice O\n. O\n\n\" O\nThe O\nclient O\n's O\ngoal O\nis O\nto O\ncomplete O\nits O\nyear O\n2000 O\nconversion O\nactivities O\nby O\nthe O\nend O\nof O\n1997 O\n, O\n\" O\nthe O\nstatement O\nsaid O\n. O\n\n-- O\nNew B-LOC\nYork I-LOC\nnewsroom O\n, O\n( O\n212 O\n) O\n859-1610 O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nWall B-ORG\nStreet I-ORG\nJournal I-ORG\n- O\nAug O\n29 O\n. O\n\nNEW B-LOC\nYORK I-LOC\n1996-08-29 O\n\nThe O\nNational B-ORG\nBasketball I-ORG\nAssociation I-ORG\nhas O\nsued O\nAmerica B-ORG\nOnline I-ORG\nInc I-ORG\n, O\nalleging O\nthat O\nthe O\nUnited B-LOC\nStates I-LOC\n' O\nNo O\n1 O\non-line O\nservice O\nis O\ndelivering O\nreal-time O\ninformation O\nabout O\nleague O\ngames O\nwithout O\nits O\npermission O\n, O\nThe B-ORG\nWall I-ORG\nStreet I-ORG\nJournal I-ORG\nreported O\non O\nThursday O\n. O\n\nThe O\nsuit O\nwas O\nfiled O\non O\nWednesday O\nin O\nfederal O\ncourt O\nin O\nManhattan B-LOC\nand O\nis O\nanother O\nlegal O\nskirmish O\nover O\nwhat O\nconstitutes O\na O\n\" O\nbroadcast O\n\" O\nin O\nthe O\ncomputer O\nage O\n. O\n\nThe O\nsuit O\ncontends O\nAmerica B-ORG\nOnline I-ORG\nwas O\nmisappropriating O\nNBA B-ORG\nproperty O\nby O\nproviding O\na O\nsite O\ncontaining O\ncontinually O\nupdated O\nscores O\nand O\nstatistics O\nof O\nNBA B-ORG\ngames O\nin O\nprogress O\n. O\n\nThe O\nnewspaper O\nalso O\nreported O\n: O\n\n* O\nBaxter B-ORG\nInternational I-ORG\nInc I-ORG\nhas O\nreached O\nan O\nagreement O\nto O\nacquire O\nAustria B-LOC\n's O\nImmuno B-ORG\nInternational I-ORG\nAG I-ORG\nin O\na O\ncomplex O\ndeal O\nvalued O\nat O\n$ O\n715 O\nmiilion O\n. O\n\n* O\nBoeing B-ORG\nCo I-ORG\nsecures O\n$ O\n5.5 O\nbillion O\nin O\norders O\nfor O\nnew O\n, O\nlarger O\n747s O\n. O\n\n* O\nPresident O\nBill B-PER\nClinton I-PER\nis O\nexpected O\nto O\npropose O\na O\ntax O\nbreak O\non O\nhome O\nsales O\n. O\n\n* O\nPhilip B-ORG\nMorris I-ORG\nCos I-ORG\nInc I-ORG\nraises O\ndividend O\n20 O\npercent O\n. O\n\n* O\nSalomon B-ORG\nBrothers I-ORG\nInc I-ORG\nanalyst O\nis O\nbullish O\non O\nInternational B-ORG\nBusiness I-ORG\nMachines I-ORG\nCorp I-ORG\n. O\n\n* O\nSierra B-ORG\nSemiconductor I-ORG\nCorp I-ORG\nputs O\nmodem O\nchipset O\nline O\nup O\nfor O\nsale O\nand O\nsets O\nlayoffs O\n. O\n\n* O\nRed B-ORG\nLion I-ORG\nHotels I-ORG\nInc I-ORG\nsays O\nit O\n's O\nholding O\nmerger O\ntalks O\nwith O\nDoubletree B-ORG\nCorp I-ORG\n. O\n\n* O\nGTE B-ORG\nCorp I-ORG\n, O\nBaby B-ORG\nBells I-ORG\nand O\ntheir O\nallies O\nready O\nto O\nlaunch O\nchallenge O\nto O\ntelecommunications O\nreform O\nlaw O\n. O\n\n* O\nEconomists O\nsee O\nsecond-quarter O\ngross O\ndomestic O\nproduct O\nrevised O\ndown O\n0.1 O\npercentage O\npoint O\n. O\n\n* O\nPresident O\nClinton B-PER\nproposes O\nfive-point O\nplan O\nto O\nclean O\nup O\ntoxic O\nwaste O\nsites O\n. O\n\n* O\nSecurities B-ORG\nand I-ORG\nExchange I-ORG\nCommission I-ORG\nacts O\nto O\nimprove O\nstock-trade O\nprices O\nfor O\ninvestors O\n. O\n\n* O\nH&R B-ORG\nBlock I-ORG\nInc I-ORG\ndelays O\nspinoff O\nof O\nits O\nstake O\nin O\nCompuServe B-ORG\nCorp I-ORG\n. O\n\n* O\nStock O\nfunds O\nsee O\ncash O\npour O\nin O\nagain O\nin O\nJuly O\n. O\n\n* O\nThe O\nFederal B-ORG\nTrade I-ORG\nCommission I-ORG\nand I-ORG\nJustice I-ORG\nDepartment I-ORG\nissue O\nnew O\nguidelines O\nfor O\nformation O\nof O\ndoctors O\n' O\nnetworks O\n. O\n\n-- O\nNew B-LOC\nYork I-LOC\nnewsroom O\n, O\n( O\n212 O\n) O\n859-1610 O\n\n-DOCSTART- O\n\nBaker B-PER\nmade O\nsecret O\ntrip O\nto O\nSyria B-LOC\nin O\nMarch O\n1995 O\n. O\n\nWASHINGTON B-LOC\n1996-08-29 O\n\nFormer O\nSecretary O\nof O\nState O\nJames B-PER\nBaker I-PER\nmade O\na O\nsecret O\ntrip O\nto O\nSyria B-LOC\nin O\nMarch O\n1995 O\nin O\nan O\nunsuccessful O\nbid O\nto O\nbreak O\nan O\nimpasse O\nin O\nnegotiations O\nbetween O\nSyria B-LOC\nand O\nIsrael B-LOC\n, O\nthe O\nWashington B-ORG\nPost I-ORG\nreported O\non O\nThursday O\n. O\n\nThe O\npaper O\nsaid O\nBaker B-PER\ndeclined O\nto O\ndiscuss O\nthe O\ntrip O\n, O\nbut O\nauthorised O\nan O\nassociate O\nto O\nconfirm O\nit O\ntook O\nplace O\nand O\ngive O\nan O\naccount O\nof O\nit O\n. O\n\nNews O\nof O\nthe O\nsecret O\ntrip O\ncame O\nafter O\nBaker B-PER\ntrashed O\nthe O\nClinton B-PER\nadministration O\nat O\nthe O\nRepublican B-MISC\nNational I-MISC\nConvention I-MISC\ntwo O\nweeks O\nago O\nfor O\nits O\nefforts O\nto O\nnudge O\nSyria B-LOC\ninto O\npeace O\nwith O\nIsrael B-LOC\n. O\n\nBaker B-PER\nmade O\nthe O\nMarch O\n1995 O\ntrip O\non O\nthe O\nexplicit O\nunderstanding O\nthat O\nit O\nremain O\na O\nsecret O\n, O\nbut O\nafter O\nhis O\nspeech O\nat O\nthe O\nGOP B-MISC\nconvention O\n, O\nIsrael B-LOC\n's O\noutgoing O\nambassador O\nItamar B-PER\nRabinovich I-PER\ntold O\na O\nreporter O\nabout O\nit O\n, O\nthe O\nPost B-ORG\nsaid O\n. O\n\nBaker B-PER\nwas O\nsecretary O\nof O\nstate O\nin O\nthe O\nRepublican B-MISC\nadministration O\nof O\nPresident O\nGeorge B-PER\nBush I-PER\n. O\n\n-DOCSTART- O\n\nClinton B-PER\nwins O\nDemocratic B-MISC\nre-nomination O\n. O\n\nCHICAGO B-LOC\n1996-08-28 O\n\nPresident O\nBill B-PER\nClinton I-PER\nwas O\nformally O\nnominated O\non O\nWednesday O\nas O\nthe O\nDemocratic B-MISC\nparty O\ncandidate O\nfor O\na O\nsecond O\nfour-year O\nterm O\nin O\nthe O\nWhite B-LOC\nHouse I-LOC\n. O\n\nClinton B-PER\nwon O\nthe O\nnomination O\nin O\na O\ntraditional O\nstate-by-state O\nroll O\ncall O\nof O\nvotes O\nat O\nthe O\nparty O\nconvention O\nand O\nwill O\naccept O\nin O\na O\nspeech O\non O\nThursday O\n. O\n\nHe O\nfaces O\nRepublican B-MISC\nchallenger O\nBob B-PER\nDole I-PER\nin O\nthe O\nNovember O\n5 O\npresidential O\nelection O\n. O\n\n-DOCSTART- O\n\nBeachcomber O\nfinds O\npiece O\nthat O\ncould O\nbe O\nTWA B-ORG\npart O\n. O\n\nATLANTIC B-LOC\nHIGHLANDS I-LOC\n, O\nN.J. B-LOC\n1996-08-28 O\n\nA O\nfoot-long O\npiece O\nof O\ndebris O\nbearing O\nmarkings O\nfrom O\na O\ncommercial O\naircraft O\nwas O\nfound O\non O\nthe O\nNew B-LOC\nJersey I-LOC\nshore O\nand O\nforwarded O\nto O\nTWA B-ORG\ncrash O\ninvestigators O\nin O\nLong B-LOC\nIsland I-LOC\n, O\nofficials O\nsaid O\non O\nWednesday O\n. O\n\nA O\nperson O\nwalking O\non O\nthe O\nshore O\nat O\nIsland B-LOC\nBeach I-LOC\nState I-LOC\nPark I-LOC\nfound O\nthe O\ndebris O\nand O\nalerted O\npolice O\nwho O\nforwarded O\nit O\nto O\nLong B-LOC\nIsland I-LOC\n, O\nNew B-LOC\nYork I-LOC\n, O\nwhere O\nthe O\nNational B-ORG\nTransportation I-ORG\nSafety I-ORG\nBoard I-ORG\nand O\nthe O\nFBI B-ORG\nare O\nconducting O\nan O\ninvestigation O\n. O\n\nThe O\nTWA B-ORG\njet O\nexploded O\nin O\na O\ndeadly O\nfireball O\nlast O\nmonth O\n, O\nkilling O\n230 O\npeople O\n, O\ncrashing O\nin O\nthe O\nAtlantic B-LOC\nOcean I-LOC\nat O\nleast O\n80 O\nmiles O\nfrom O\nwhere O\nthe O\ndebris O\nwas O\nfound O\nWednesday O\n. O\n\nSeveral O\nother O\nitems O\nhave O\nbeen O\nreported O\nfound O\nalong O\nthe O\nNew B-LOC\nJersey I-LOC\nshore O\n, O\nmost O\nof O\nit O\nsuch O\npersonal O\nitems O\nas O\nwallets O\n, O\nshoes O\nand O\njewelry O\n. O\n\nInvestigators O\nsaid O\nthey O\nstill O\ndo O\nnot O\nhave O\nenough O\nevidence O\nto O\ndetermine O\nwhether O\na O\nbomb O\n, O\na O\nmissile O\nor O\nmechanical O\nfailure O\ncaused O\nthe O\ncrash O\n. O\n\n-DOCSTART- O\n\nFEATURE O\n- O\nRich O\nnew O\ndetail O\non O\nU.S. B-MISC\nCivil I-MISC\nWar I-MISC\nunearthed O\n. O\n\nLeila B-PER\nCorcoran I-PER\n\nWASHINGTON B-LOC\n1996-08-29 O\n\nA O\nfreed O\nblack O\nman O\nwrites O\nto O\nhis O\nstill-enslaved O\nwife O\n, O\na O\nmother O\npleads O\nwith O\nAbraham B-PER\nLincoln I-PER\non O\nbehalf O\nof O\nher O\nson O\nand O\na O\nmaimed O\nsoldier O\nposes O\nfor O\nan O\nofficial O\nphotograph O\nin O\nnewly O\nreopened O\nrecords O\nthat O\nbring O\nthe O\nU.S. B-MISC\nCivil I-MISC\nWar I-MISC\nback O\nto O\nlife O\n. O\n\nWorking O\nin O\nthe O\nbasement O\nof O\nthe O\nNational B-ORG\nArchives I-ORG\n, O\nmembers O\nof O\nthe O\nCivil B-ORG\nWar I-ORG\nConservation I-ORG\nCorps I-ORG\nare O\norganising O\nthe O\nmilitary O\nrecords O\nof O\nvolunteers O\nwho O\nfought O\nfor O\nthe O\nNorth B-LOC\nso O\nthat O\nthey O\ncan O\nbe O\npreserved O\non O\nmicrofilm O\n. O\n\nThe O\nfaded O\ndocuments O\nhave O\nbeen O\nstowed O\naway O\nin O\nthe O\nArchives B-ORG\nsince O\nit O\nopened O\nin O\n1935 O\nand O\nhave O\nrarely O\nseen O\nthe O\nlight O\nof O\nday O\n. O\n\nEach O\nsoldier O\n's O\nfile O\nis O\na O\ngold O\nmine O\nof O\ninformation O\n: O\nenlistment O\npapers O\n, O\nmuster O\nrolls O\n, O\nmedical O\nrecords O\n, O\ndischarge O\ncertificates O\n, O\nletters O\nand O\nphotographs O\n. O\n\nSince O\nthe O\nproject O\nbegan O\nalmost O\ntwo O\nyears O\nago O\n, O\ncorps O\nvolunteers O\nhave O\nfocused O\non O\nAfrican B-MISC\nAmerican I-MISC\ntroops O\n, O\npreparing O\nrecords O\nin O\ntime O\nfor O\nthe O\nunveiling O\nin O\nWashington B-LOC\nthis O\nyear O\nof O\na O\nspecial O\nmemorial O\nto O\nblack O\nsoldiers O\nwho O\nfought O\nin O\nthe O\nwar O\n. O\n\nMore O\nthan O\n185,000 O\nblack O\nsoldiers O\nfought O\nand O\n37,000 O\ndied O\n. O\n\nIn O\none O\nletter O\n, O\na O\nblack O\nsoldier O\nheading O\nSouth B-LOC\nwrote O\nhis O\nwife O\n, O\n\" O\nthough O\ngreat O\nis O\nthe O\npresent O\nnational O\ndifficulties O\nyet O\nI O\nlook O\nforward O\nto O\na O\nbrighter O\nday O\nwhen O\nI O\nshall O\nhave O\nthe O\noportunity O\nof O\nseeing O\nyou O\nin O\nthe O\nfull O\nenjoyment O\nof O\nfreedom O\n. O\n\n\" O\nI O\nwould O\nlike O\nto O\nno O\n( O\nsic O\n) O\nif O\nyou O\nare O\nstill O\nin O\nslavery O\nif O\nyou O\nare O\n, O\nit O\nwill O\nnot O\nbe O\nlong O\nbefore O\nwe O\nshall O\nhave O\ncrushed O\nthe O\nsystem O\nthat O\nnow O\noppreses O\nyou O\nfor O\nin O\nthe O\ncourse O\nof O\nthree O\nmonths O\nyou O\nshall O\nhave O\nyour O\nliberty O\n. O\n\nGreat O\nis O\nthe O\noutpouring O\nof O\nthe O\ncoloured O\npeople O\nthat O\nis O\nnow O\nrallying O\nwith O\nthe O\nheart O\nof O\nlions O\nagainst O\nthe O\nvery O\ncurse O\nthat O\nhas O\nseparated O\nyou O\nand O\nme O\n. O\n\" O\n\nIn O\nanother O\nletter O\ndated O\nJanuary O\n1865 O\n, O\na O\nwell-to-do O\nWashington B-LOC\nmatron O\nwrote O\nto O\nLincoln B-PER\nto O\nplead O\nfor O\nher O\nson O\n, O\nwho O\nfaced O\na O\ndishonourable O\ndischarge O\nfrom O\nthe O\nArmy B-ORG\n. O\n\" O\n\nJames B-PER\nis O\na O\nprisoner O\nfor O\na O\nthoughtless O\nact O\nof O\nfolly O\n, O\nwhile O\nthose O\nwho O\nhave O\ndone O\nnothing O\nfor O\nthe O\ncause O\nare O\nfree O\n, O\n\" O\nshe O\nwrote O\n. O\n\nLincoln B-PER\n's O\nnotation O\non O\nthe O\nletter O\nread O\n: O\n\" O\nIf O\nhis O\ncolonel O\nwill O\nsay O\nin O\nwriting O\non O\nthis O\nsheet O\nhe O\nis O\nwilling O\nto O\nreceive O\nthis O\nman O\nback O\nto O\nthe O\nregiment O\n, O\nI O\nwill O\npardon O\nand O\nsend O\nhim O\n. O\n\" O\n\nThe O\nsoldier O\nwas O\nsubsequently O\npardoned O\n. O\n\nWhile O\nthe O\nletters O\nspeak O\nto O\nthe O\nanguish O\nof O\nseparation O\n, O\na O\nphotograph O\nof O\na O\nblack O\namputee O\nspeaks O\nto O\nthe O\nterrible O\nphysical O\ncost O\nof O\nthe O\nwar O\n. O\n\nIn O\na O\npicture O\nrequired O\nfor O\nhis O\nmilitary O\ndischarge O\n, O\nPvt O\n. O\n\nLewis B-PER\nMartin I-PER\n, O\nwith O\nhaunted O\neyes O\n, O\nposed O\nbare-chested O\nto O\nreveal O\nhis O\nmissing O\narm O\nand O\nleg O\n, O\nblown O\noff O\nduring O\na O\nbattle O\nat O\nPetersburg B-LOC\n, O\nVirginia B-LOC\n, O\nin O\nJuly O\n1864 O\n. O\n\nThe O\nwork O\non O\nblack O\ntroops O\nhas O\nprovided O\nnew O\ninsight O\ninto O\nthe O\nrhythms O\nof O\nplantation O\ntalk O\nand O\nculture O\n, O\nsaid O\nJohn B-PER\nSimon I-PER\n, O\nprofessor O\nof O\nhistory O\nat O\nSouthern B-ORG\nIllinois I-ORG\nUniversity I-ORG\nat I-ORG\nCarbondale I-ORG\nand O\neditor O\nof O\nGen O\n. O\n\nUlysses B-PER\nGrant I-PER\n's O\npapers O\n. O\n\n\" O\nThese O\n( O\nwritings O\n) O\nare O\nnot O\nonly O\npoetic O\nbut O\na O\nlinguistic O\ntreasure O\ntrove O\n. O\n\nThis O\nis O\nthe O\nfirst O\ngeneration O\nof O\nAfrican B-MISC\nAmericans I-MISC\nthat O\nreally O\ncan O\nexpress O\nitself O\nwithout O\nfear O\nand O\npunishment O\n, O\n\" O\nSimon B-PER\nsaid O\n. O\n\n\" O\nI O\nthink O\nthere O\n's O\nprobably O\na O\nwhole O\nlot O\nof O\nmaterial O\nthat O\nwould O\nexpand O\nour O\nunderstanding O\nof O\nthe O\nsociology O\nof O\nthe O\nwar O\n, O\n\" O\nsaid O\nEdward B-PER\nSmith I-PER\n, O\ndirector O\nof O\nAmerican B-ORG\nStudies I-ORG\nat O\nAmerican B-ORG\nUniversity I-ORG\nin O\nWashington B-LOC\n. O\n\nThe O\nwar O\nbetween O\nthe O\nNorth B-LOC\nand O\nSouth B-LOC\nraged O\nfor O\nnearly O\nfour O\nyears O\n, O\nclaimed O\nthe O\nlives O\nof O\nhalf O\na O\nmillion O\nAmericans B-MISC\nand O\nforever O\nseared O\nthe O\nnation O\n's O\nconsciousness O\n. O\n\nSouthern B-MISC\nrecords O\nhave O\nalready O\nbeen O\npreserved O\n. O\n\nThey O\nwere O\nput O\non O\nmicrofilm O\nabout O\n30 O\nyears O\nago O\nthrough O\na O\ngrant O\nfrom O\nthe O\nUnited B-ORG\nDaughters I-ORG\nof I-ORG\nthe I-ORG\nConfederacy I-ORG\n. O\n\nThe O\nCivil B-ORG\nWar I-ORG\nConservation I-ORG\nCorps I-ORG\nis O\nmostly O\nretirees O\njoined O\nby O\nstudents O\nduring O\nthe O\nschool O\nyear O\n. O\n\nDirector O\nBudge B-PER\nWeidman I-PER\n, O\nwho O\nhas O\nshepherded O\nthe O\nproject O\nfrom O\nthe O\nbeginning O\n, O\npredicts O\nit O\nwill O\ntake O\nup O\nto O\na O\ndecade O\nto O\ncomplete O\n. O\n\nThe O\nwork O\nwas O\ninspired O\nby O\na O\nNational B-ORG\nPark I-ORG\nService I-ORG\nplan O\nto O\nput O\ncomputer O\ndatabases O\nat O\nCivil B-MISC\nWar I-MISC\nbattlefields O\nacross O\nthe O\ncountry O\nso O\nthat O\nAmericans B-MISC\nmight O\nresearch O\ntheir O\nancestors O\n. O\n\nThe O\nrecords O\nalso O\nprovide O\ninsight O\ninto O\nmedical O\nthinking O\nof O\nthe O\nday O\n. O\n\nOne O\nsoldier O\nwas O\ndischarged O\nbecause O\nof O\n\" O\nmental O\nincapacity O\nand O\ninebetude O\n( O\nsic O\n) O\nof O\nthe O\nbrain O\n, O\nalleged O\nby O\nthe O\nPatient O\nto O\nbe O\nconnected O\nwith O\na O\nfall O\non O\nthe O\nhead O\nbut O\nbelieved O\nto O\narise O\nfrom O\nlong O\ncontinued O\nand O\nexcessive O\nmasturbation O\n. O\n\" O\n\n-DOCSTART- O\n\nClinton B-PER\narrives O\nin O\nChicago B-LOC\non O\nday O\nof O\nre-nomination O\n. O\n\nCHICAGO B-LOC\n1996-08-28 O\n\nPresident O\nBill B-PER\nClinton I-PER\narrived O\nin O\nChicago B-LOC\non O\nWednesday O\nas O\nthe O\nDemocratic B-MISC\nconvention O\nprepared O\nto O\nre-nominate O\nhim O\nfor O\na O\nsecond O\nfour-year O\nterm O\n. O\n\nClinton B-PER\nflew O\nin O\nby O\nhelicopter O\nfrom O\nMichigan B-LOC\nCity I-LOC\n, O\nIndiana B-LOC\n, O\nafter O\nending O\na O\nfour-day O\n, O\n559-mile O\ntrip O\naboard O\na O\ncampaign O\ntrain O\nfrom O\nWashington B-LOC\n. O\n\n-DOCSTART- O\n\nNew O\nbomb O\nattacks O\non O\nCorsica B-LOC\ndespite O\ncrackdown O\nvow O\n. O\n\nSylvie B-PER\nFlorence I-PER\n\nAJACCIO B-LOC\n, O\nCorsica B-LOC\n1996-08-29 O\n\nSeparatist O\nguerrillas O\nplanted O\ntwo O\nbombs O\novernight O\nat O\ngovernment O\noffices O\non O\nthe O\nFrench B-MISC\nMediterranean B-MISC\nisland O\nof O\nCorsica B-LOC\ndespite O\nfresh O\nwarnings O\nof O\na O\ncrackdown O\nby O\nParis B-LOC\n, O\npolice O\nsaid O\non O\nThursday O\n. O\n\nIn O\nthe O\nlatest O\nin O\na O\nwave O\nof O\nattacks O\n, O\na O\ntwo O\nkg O\n( O\nfour O\nlb O\n) O\nbomb O\nseriously O\ndamaged O\ntwo O\nfloors O\nof O\nAgriculture B-ORG\nMinistry I-ORG\noffices O\nlocated O\njust O\n50 O\nmetres O\n( O\nyards O\n) O\nfrom O\na O\npolice O\nstation O\nin O\nthe O\ncentre O\nof O\nthe O\nisland O\ncapital O\nAjaccio B-ORG\n. O\n\nNo O\none O\nwas O\nhurt O\n. O\n\nA O\nsecond O\ndevice O\n, O\npacked O\nwith O\nfive O\nkg O\n( O\n10 O\nlbs O\n) O\nof O\nexplosive O\n, O\nwas O\ndefused O\nbefore O\nit O\ncould O\ngo O\noff O\n, O\npolice O\nsaid O\n. O\n\nThe O\nnew O\nattacks O\nfollowed O\nby O\na O\nday O\na O\nwarning O\nof O\na O\nnew O\n\" O\nget-tough O\n\" O\npolicy O\nby O\nParis B-LOC\ntoward O\nthe O\nseparatists O\n, O\nwho O\nseek O\ngreater O\nautonomy O\n. O\n\nInterior O\nMinister O\nJean-Louis B-PER\nDebre I-PER\n, O\nunder O\nfire O\nfor O\nstaging O\nsecret O\ntalks O\nwith O\none O\nof O\nthe O\nlargest O\nof O\nseveral O\nrival O\nunderground O\nnationalist O\ngroups O\n, O\ntold O\nthe O\ndaily O\nLa B-ORG\nCorse I-ORG\nin O\na O\nstatement O\nhe O\nhad O\ngiven O\n\" O\nfirm O\norders O\n\" O\nto O\npolice O\nto O\nround O\nup O\nthose O\nresponsible O\nfor O\nthe O\nbombings O\nand O\nbring O\nthem O\nto O\njustice O\n. O\n\nJudges O\non O\nthe O\nisland O\nhad O\naccused O\nParis B-LOC\nof O\ntaking O\na O\nlax O\nstance O\non O\nguerrilla O\nviolence O\nwhile O\nconducting O\nsecret O\nbut O\nwidely-reported O\ntalks O\nwith O\nseparatists O\nwhich O\nhave O\nnow O\nfailed O\n. O\n\nThe O\nlatest O\nbombing O\n, O\nclose O\non O\nthe O\nheels O\nof O\nthe O\nnew O\norders O\n, O\nbrought O\ncharges O\nthat O\npolice O\nwere O\npowerless O\n. O\n\n\" O\nNo O\nsearches O\n, O\nno O\narrests O\n, O\nno O\npolice O\nreinforcements O\nvisible O\non O\nthe O\nisland O\n, O\ndespite O\nthe O\nministry O\n's O\npromises O\n, O\n\" O\nthe O\ndaily O\nFrance-Soir B-ORG\nlamented O\n. O\n\n\" O\nOn O\nthe O\nisland O\n, O\nas O\nat O\nthe O\nPlace B-LOC\nBeauvau I-LOC\n( O\nthe O\nInterior B-ORG\nMinistry I-ORG\n's O\nParis B-LOC\naddress O\n) O\n, O\npeople O\nare O\nwell O\naware O\nwho O\nis O\nwho O\nand O\nwho O\nis O\ndoing O\nwhat O\n. O\n\nIt O\nis O\ntime O\nto O\nend O\nthis O\nnightly O\nfarce O\n, O\n\" O\nsaid O\nthe O\npro-government O\ndaily O\nLe B-ORG\nFigaro I-ORG\nin O\nan O\neditorial O\n. O\n\nNo O\none O\nimmediately O\nclaimed O\nresponsibility O\nfor O\nThursday O\n's O\nincidents O\n, O\nwhich O\nbrought O\nto O\n23 O\nthe O\nnumber O\nof O\nguerrilla O\nattacks O\non O\nthe O\nresort O\nisland O\nsince O\nmid-August O\n, O\nwhen O\nseparatist O\nguerrillas O\nended O\na O\nshaky O\nseven-month O\ntruce O\n. O\n\nCorsica B-LOC\nhas O\nbeen O\nracked O\nby O\nlow-level O\nseparatist-inspired O\nviolence O\n, O\nprincipally O\ndirected O\nagainst O\ngovernment O\ntargets O\n, O\nfor O\ntwo O\ndecades O\n. O\n\nThe O\ndaily O\nLe B-ORG\nMonde I-ORG\nreported O\non O\nWednesday O\nsome O\nseparatist O\nmovements O\nwere O\nconsidering O\ntaking O\ntheir O\nattacks O\nto O\nthe O\nFrench B-MISC\nmainland O\non O\nthe O\nprinciple O\nthat O\n\" O\n300 O\ngrammes O\nof O\nexplosives O\non O\nthe O\ncontinent O\nhave O\nmore O\nimpact O\nthan O\n300 O\nkilos O\nin O\nCorsica B-LOC\n\" O\n. O\n\nThe O\nnewspaper O\nsaid O\nseparatists O\nmay O\ntake O\nadvantage O\nof O\nsocial O\nunrest O\nwidely O\nexpected O\non O\nthe O\nmainland O\nin O\ncoming O\nweeks O\nover O\ngovernment O\nausterity O\nplans O\nto O\nstoke O\na O\npopular O\nbacklash O\nagainst O\nthe O\ngovernment O\n. O\n\n-DOCSTART- O\n\nSweden B-LOC\n's O\nOM B-ORG\nto O\nopen O\nLondon B-LOC\nforest O\nproducts O\nbourse O\n. O\n\nSTOCKHOLM B-LOC\n1996-08-29 O\n\nSwedish B-MISC\noptions O\nand O\nderivatives O\nexchange O\nOM B-ORG\nGruppen I-ORG\nAB I-ORG\nsaid O\non O\nThursday O\nit O\nwould O\nopen O\nan O\nelectronic O\nbourse O\nfor O\nforest O\nindustry O\nproducts O\nin O\nLondon B-LOC\nin O\nthe O\nfirst O\nhalf O\nof O\n1997 O\n. O\n\n\" O\nTogether O\nwith O\nsubsidiaries O\nOMLX B-ORG\n, O\nthe O\nLondon B-ORG\nSecurities I-ORG\n& I-ORG\nDerivatives I-ORG\nExchange I-ORG\nand O\nOM B-ORG\nStockholm I-ORG\n, O\nOM B-ORG\nGruppen I-ORG\nwill O\nopen O\nan O\ninternational O\nelectronic O\nbourse O\nfor O\nforest O\nproducts O\nin O\nthe O\nfirst O\nhalf O\nof O\n1997 O\n, O\n\" O\nOM B-ORG\nGruppen I-ORG\nsaid O\nin O\na O\nstatement O\n. O\n\nThe O\nfirst O\ncommodity O\nto O\nbe O\ntraded O\non O\nthe O\nPULPEX B-ORG\nbourse O\nwill O\nbe O\npulp O\n, O\nbut O\nOM B-ORG\nsaid O\ntrade O\nwould O\nbe O\nextended O\nto O\ninclude O\nproducts O\nsuch O\nas O\ntimber O\n, O\nrecycled O\npaper O\nand O\nother O\npaper O\nqualities O\n. O\n\n\" O\nThrough O\nthe O\nestablishment O\nof O\nPULPEX B-ORG\n, O\nLondon B-LOC\nwill O\nhave O\na O\ncommodities O\nbourse O\nfor O\nforest O\nproducts O\nwhich O\ncomplements O\nexisting O\nbourses O\nfor O\noil O\n, O\nmetals O\nand O\n' O\nsofts O\n' O\n( O\ncoffee O\n, O\nsugar O\nand O\ncocoa O\n) O\n, O\n\" O\nOM B-ORG\nsaid O\n. O\n\nPULPEX B-ORG\nwas O\nthe O\nresult O\nof O\na O\nthree-year O\nproject O\nrun O\nin O\ncooperation O\nbetween O\nOM B-ORG\nand O\nrepresentatives O\nof O\nthe O\nforest O\nindustry O\n, O\nthe O\ncompany O\nsaid O\n. O\n\nHuge O\nswings O\nin O\nthe O\nprice O\nof O\npulp O\nover O\nthe O\npast O\nfew O\nyears O\nhave O\nmade O\npulp O\nproducers O\n' O\nprofitability O\nunpredictable O\n, O\nand O\nmade O\ninvesting O\nin O\nnew O\nproduction O\ncapacity O\na O\nrisky O\nbusiness O\n. O\n\n\" O\nWithout O\nthe O\nability O\nto O\nhedge O\nprices O\n, O\nchanges O\nin O\nthe O\nworld O\nmarket O\nprice O\nfor O\npulp O\nhas O\nhad O\nan O\nimmediate O\nimpact O\non O\nplayers O\n' O\nprofitability O\n, O\n\" O\nOM B-ORG\nsaid O\n. O\n\nIt O\nsaid O\nglobal O\nproduction O\nof O\npulp O\namounted O\nto O\naround O\n200 O\nmillion O\ntonnes O\nper O\nyear O\n, O\nof O\nwhich O\naround O\n20 O\npercent O\nor O\n40 O\nmillion O\ntonnes O\nwas O\nsold O\non O\nthe O\nspot O\nmarket O\n. O\n\nAt O\ncurrent O\nprices O\n, O\nthe O\nvalue O\nof O\nthis O\nproduction O\nwas O\naround O\n$ O\n25 O\nbillion O\n. O\n\nPULPEX B-ORG\nwill O\nbe O\nboth O\na O\nmarketplace O\nand O\na O\nclearing O\nhouse O\n, O\nOM B-ORG\nsaid O\n, O\nadding O\nthat O\nthe O\nBritish B-ORG\nSecurities I-ORG\nand I-ORG\nInvestments I-ORG\nBoard I-ORG\nhad O\nbeen O\ninformed O\nof O\nOM B-ORG\n's O\nplans O\n. O\n\nPULPEX B-ORG\n's O\nclearing O\noperation O\nwill O\nbe O\ncovered O\nby O\nthe O\nparent O\ncompany O\nguarantee O\nissued O\nby O\nOM B-ORG\nGruppen I-ORG\nto O\nits O\nwholly-owned O\nbourses O\nand O\nclearing O\norganisations O\n. O\n\n-- O\nStockholm B-LOC\nnewsroom O\n, O\n+46-8-700 O\n1006 O\n\n-DOCSTART- O\n\nAmsterdam-Rotterdam-Antwerp B-LOC\noil O\nstock O\nlevels O\nfall O\n. O\n\nAMSTERDAM B-LOC\n1996-08-29 O\n\nOil O\nproduct O\ninventories O\nheld O\nin O\nindependent O\ntankage O\nin O\nthe O\nAmsterdam-Rotterdam-Antwerp B-LOC\narea O\nwere O\nat O\nthe O\nfollowing O\nlevels O\n, O\nwith O\nweek-ago O\nand O\nyear-ago O\nlevels O\n, O\nindustry O\nsources O\nsaid O\n. O\n\nAll O\nfigures O\nin O\nthousands O\nof O\ntonnes O\n: O\n\n29/8/96 O\n22/8/96 O\n1/9/95 O\n\nGasoline O\n400 O\n400-425 O\n425 O\n\nNaphtha O\n50-75 O\n75-100 O\n50-75 O\n\nGas O\noil O\n1,600 O\n1,650 O\n1,850-1,900 O\n\nFuel O\noil O\n325 O\n325-350 O\n425 O\n\nJet O\nkero O\n15 O\n15-20 O\n25 O\n\nMotor O\ngasoline O\nstocks O\ndipped O\nslightly O\nas O\nbarges O\nleft O\nfor O\nGermany B-LOC\n, O\nbut O\nthere O\nwere O\nfew O\ninflows O\nof O\ncargoes O\n. O\n\nNaphtha O\ninventories O\nalso O\ndropped O\nas O\nGermany B-LOC\nagain O\ntook O\nbarges O\nand O\nno O\ncargoes O\nentered O\nARA O\n. O\n\nGas O\noil O\nstocks O\nfell O\nwith O\nsome O\ncargoes O\narriving O\nfrom O\nthe O\nformer O\nSoviet B-LOC\nUnion I-LOC\n, O\nbut O\nvery O\nfast O\nthroughput O\nto O\nmarkets O\nin O\nBenelux B-LOC\n, O\nGermany B-LOC\nand O\nSwitzerland B-LOC\n. O\n\nFuel O\noil O\ninventories O\ndipped O\nslightly O\nwith O\nsome O\nstraight-run O\narrivals O\n, O\nbut O\nfair O\nbunkering O\ndemand O\nremoving O\nmore O\nmaterial O\n. O\n\nJet O\nfuel O\nstocks O\nlowered O\nas O\nthe O\naviation O\nsector O\nbought O\n. O\n\n-- O\nPhilip B-PER\nBlenkinsop I-PER\n, O\nAmsterdam B-LOC\nnewsroom O\n31 O\n20 O\n504 O\n5000 O\n\n-DOCSTART- O\n\nGerman B-MISC\nanti-nuclear O\nactivists O\nin O\npantomime O\nprotest O\n. O\n\nBONN B-LOC\n1996-08-29 O\n\nAbout O\n200 O\nGerman B-MISC\nanti-nuclear O\nactivists O\nprotested O\non O\nThursday O\nagainst O\nnuclear O\nwaste O\ntransportation O\nby O\nre-enacting O\nscenes O\nfrom O\na O\ndemonstration O\nthey O\nstaged O\nin O\nMay O\nthat O\nturned O\ninto O\na O\nviolent O\nclash O\nwith O\npolice O\n. O\n\nActivists O\ndressed O\nas O\npolice O\nbrandished O\nbatons O\nand O\nfiring O\na O\ntheatre-prop O\nwater O\ncannon O\nat O\n\" O\ndemonstrators O\n\" O\n. O\n\nPolice O\nwho O\nhad O\nturned O\nout O\nin O\nforce O\nall O\naround O\nthe O\ngovernment O\nquarter O\nfearing O\nviolence O\nlooked O\non O\nin O\namusement O\n. O\n\nLast O\nMay O\ndozens O\nof O\ndemonstrators O\nand O\npolice O\nwere O\ninjured O\nin O\nviolent O\nclashes O\naround O\nthe O\nGorleben B-LOC\nnuclear O\nwaste O\ndepot O\nas O\nhundreds O\nof O\nprotesters O\ntried O\nto O\nblock O\na O\ndelivery O\nof O\nwaste O\nby O\ntrain O\nand O\ntruck O\n. O\n\n-DOCSTART- O\n\nItaly B-LOC\npolice O\narrest O\nfive O\nover O\ndouble O\nMafia O\nkilling O\n. O\n\nCATANIA B-LOC\n, O\nSicily B-LOC\n1996-08-29 O\n\nItalian B-MISC\nPolice O\nsaid O\non O\nThursday O\nthey O\nhad O\narrested O\nfive O\npeople O\nin O\nconnection O\nwith O\nthe O\nslaying O\nof O\nthe O\ndaughter O\nand O\n14-year-old O\nnephew O\nof O\na O\nMafia O\nboss O\nearlier O\nthis O\nweek O\n. O\n\nSanta B-PER\nPuglisi I-PER\n, O\n22 O\n, O\nand O\nSalvatore B-PER\nBotta I-PER\nwere O\ngunned O\ndown O\nin O\na O\ncemetery O\nin O\nthis O\neastern O\nSicilian B-MISC\ncity O\non O\nTuesday O\nin O\na O\ncrime O\nwhich O\nshocked O\neven O\nhardened O\nanti-Mafia O\ninvestigators O\n. O\n\nThe O\narrests O\nfollowed O\na O\ntip-off O\nfrom O\na O\nmarried O\ncouple O\nwho O\nunexpectedly O\nshowed O\nup O\nat O\ninvestigators O\n' O\noffices O\non O\nWednesday O\n. O\n\" O\n\nThey O\nwanted O\nto O\nget O\na O\nweight O\noff O\ntheir O\nconsciences O\n, O\n\" O\na O\npolice O\nspokesman O\nsaid O\n. O\n\nHe O\nadded O\nthe O\ncouple O\nhad O\nalso O\nshed O\nlight O\non O\nthe O\nmurder O\nlast O\nyear O\nof O\nthe O\nwife O\nof O\nMafia O\nboss O\nNitto B-PER\nSantapaola I-PER\n. O\n\nPuglisi B-PER\nwas O\nshot O\nas O\nshe O\nknelt O\npraying O\nby O\nthe O\ntomb O\nof O\nher O\nyoung O\nhusband O\n, O\nwho O\nwas O\nhimself O\nkilled O\nlast O\nyear O\nin O\na O\nMafia O\nambush O\n. O\n\nBotta B-PER\n, O\nwho O\nhad O\naccompanied O\nPuglisi B-PER\nto O\nthe O\ncemetary O\n, O\ntried O\nto O\nflee O\nthe O\nlone O\ngunman O\nbut O\nwas O\ncaught O\nand O\nkilled O\n. O\n\n-DOCSTART- O\n\nThieves O\nmake O\noff O\nwith O\ncash O\nfrom O\nprison O\ncanteen O\n. O\n\nLIMERICK B-LOC\n, O\nIreland B-LOC\n1996-08-29 O\n\nThieves O\nstole O\nalmost O\n2,000 O\nIrish B-MISC\npounds O\n( O\n$ O\n3,000 O\n) O\nfrom O\nthe O\nofficers O\n' O\ncanteen O\nof O\na O\nLimerick B-LOC\njail O\non O\nThursday O\nwhile O\nwarders O\nslept O\nin O\na O\nroom O\nupstairs O\n. O\n\nPolice O\nsaid O\nthe O\nthieves O\nintercepted O\na O\nwoman O\narriving O\nto O\nwork O\nat O\nthe O\ncanteen O\n, O\nforced O\nher O\nto O\nopen O\nthe O\nsafe O\nwhere O\ntakings O\nwere O\nkept O\nand O\nmade O\noff O\nwith O\nthe O\ncash O\n. O\n\nWhile O\nthe O\nrobbery O\nwas O\ngoing O\non O\n, O\nseveral O\nofficers O\nwere O\nasleep O\nin O\na O\nroom O\nover O\nthe O\ncanteen O\n, O\nwhich O\nis O\nin O\nthe O\ngrounds O\nof O\nthe O\nprison O\non O\nIreland B-LOC\n's O\nsouthwest O\ncoast O\n. O\n\n-DOCSTART- O\n\nItalians B-MISC\nhold O\nHIV-pensioner B-MISC\nfor O\nharassing O\nhookers O\n. O\n\nGENOA B-LOC\n, O\nItaly B-LOC\n1996-08-29 O\n\nItalian B-MISC\npolice O\nsaid O\non O\nThursday O\nthey O\nhad O\narrested O\na O\n61-year-old O\nman O\nafter O\nhe O\nfired O\nblank O\nshots O\nat O\nprostitutes O\nhe O\nblamed O\nfor O\nspreading O\nAIDS B-MISC\n. O\n\nThe O\npensioner O\n, O\nnamed O\nonly O\nas O\nPietro B-PER\nT. I-PER\n, O\ntold O\ninvestigators O\nhe O\nwas O\ninfected O\nwith O\nHIV B-MISC\n, O\nthe O\nAIDS B-MISC\nvirus O\n, O\nand O\nhis O\nwife O\nhad O\ndied O\nof O\nthe O\ndisease O\n. O\n\nHe O\ndid O\nnot O\nsay O\nhow O\nthey O\nhad O\ncontracted O\nthe O\nillness O\n. O\n\nPolice O\nsaid O\nthe O\nman O\nhad O\nrecently O\nbeen O\nspotted O\ncruising O\nred-light O\nareas O\nin O\nthis O\nnorthern O\nItalian B-MISC\ncity O\n, O\nhurling O\nabuse O\nat O\nprostitutes O\nand O\nfiring O\nblank O\nshots O\nat O\nthem O\n. O\n\nPolice O\nsaid O\nthey O\nfound O\nin O\nhis O\napartment O\ntwo O\nfake O\nguns O\nand O\na O\npistol O\nthat O\nwould O\nonly O\nfire O\nblanks O\n. O\n\" O\n\nAlthough O\nfake O\nguns O\nare O\nlegal O\n, O\nthe O\nuse O\nhe O\nmade O\nof O\nthem O\nmeans O\nhe O\ncould O\nbe O\ntried O\n, O\n\" O\na O\npolice O\nofficial O\nsaid O\n. O\n\n-DOCSTART- O\n\nBodies O\nfound O\nat O\nsite O\nof O\nRussian B-MISC\njet O\ncrash O\n- O\nofficials O\n. O\n\nOSLO B-LOC\n1996-08-29 O\n\nBodies O\nhave O\nbeen O\nsighted O\nbut O\nno O\nsurvivors O\nhave O\nyet O\nbeen O\nfound O\nat O\nthe O\nsite O\nof O\nThursday O\n's O\ncrash O\nof O\na O\nRussian B-MISC\nairliner O\non O\nNorway B-LOC\n's O\nremote O\nArctic B-MISC\nisland O\nof O\nSpitzbergen B-LOC\n, O\nNorwegian B-MISC\nofficials O\nsaid O\n. O\n\n\" O\nWe O\nhave O\nfound O\ndead O\npeople O\n, O\n\" O\nsaid O\nRune B-PER\nHansen I-PER\n, O\nthe O\nisland O\n's O\ndeputy O\ngovernor O\n, O\ntold O\nNorwegian B-MISC\ntelevision O\n. O\n\nThe O\nNorwegian B-MISC\nnews O\nagency O\nNTB B-ORG\nquoted O\nanother O\nofficial O\non O\nthe O\nisland O\nas O\nsaying O\nno O\nsurvivors O\nhad O\nbeen O\nfound O\n. O\n\nThe O\nVnukovo B-ORG\nAirlines I-ORG\nTupolev B-MISC\n154 I-MISC\nflight O\nfrom O\nMoscow B-LOC\n, O\ncarrying O\n129 O\npassengers O\nand O\na O\ncrew O\nof O\n12 O\n, O\ncrashed O\nin O\nbad O\nweather O\n10 O\nkm O\n( O\nsix O\nmiles O\n) O\neast O\nof O\nLongyearbyen B-LOC\n, O\nthe O\nisland O\n's O\nonly O\nairstrip O\n, O\nofficials O\nsaid O\n. O\n\nFirst O\nrescuers O\narrived O\nshortly O\nafter O\n1 O\np.m. O\n( O\n1100 O\nGMT B-MISC\n) O\nand O\nreported O\nsoon O\nafterwards O\nthat O\nmost O\nof O\nthe O\nthree-engine O\njet O\n's O\nwreckage O\nwas O\nscattered O\naround O\nthe O\ntop O\nof O\nthe O\nsmall O\nOpera B-LOC\nmountain O\nwhile O\nthe O\nrest O\nhad O\nslid O\ndown O\nthe O\nmountainside O\n. O\n\nAir O\ntraffic O\nofficials O\nsaid O\nthey O\nhad O\nlost O\ncontact O\nwith O\nthe O\nflight O\n, O\nscheduled O\nto O\narrive O\nat O\naround O\n10.15 O\na.m. O\n( O\n0815 O\nGMT B-MISC\n) O\n, O\nshortly O\nbefore O\nit O\nwas O\ndue O\nto O\nland O\n. O\n\nSpitzbergen B-LOC\nis O\na O\nNorwegian B-MISC\ncoal-mining O\nsettlement O\n. O\n\nThe O\nonly O\nother O\ncommunity O\nis O\nin O\nthe O\nRussian B-MISC\nvillage O\nof O\nBarentsburg B-LOC\n. O\n\nRussia B-LOC\nand O\nNorway B-LOC\nshare O\nthe O\nisland O\n's O\nresources O\nunder O\na O\ntreaty O\ndating O\nback O\nto O\nthe O\n1920s O\n. O\n\n-DOCSTART- O\n\nGaleforce O\nwinds O\nand O\nheavy O\nrains O\nbatter O\nBelgium B-LOC\n. O\n\nBRUSSELS B-LOC\n1996-08-29 O\n\nTorrential O\nrains O\nand O\ngaleforce O\nwinds O\nbattered O\nBelgium B-LOC\non O\nThursday O\ncausing O\nwidespread O\ndamage O\nas O\nsome O\nareas O\nhad O\nmore O\nrainfall O\nin O\n24 O\nhours O\nthan O\nthey O\nnormally O\nget O\nin O\na O\nmonth O\n, O\nthe O\nmeteorological O\noffice O\nsaid O\n. O\n\nCellars O\nwere O\nflooded O\n, O\ntrees O\nuprooted O\nand O\nroofs O\ndamaged O\n, O\nbut O\nthere O\nwere O\nno O\nreports O\nof O\nany O\ninjuries O\n, O\nan O\ninterior O\naffairs O\nministry O\nspokesman O\nsaid O\n. O\n\nSome O\ntrains O\nwere O\ndelayed O\nas O\nfallen O\ntrees O\nblocked O\nlines O\n. O\n\nBrussels B-LOC\nreceived O\n5.6 O\ncm O\n( O\n2.24 O\ninches O\n) O\nof O\nwater O\nin O\nthe O\npast O\n24 O\nhours O\n-- O\ncompared O\nto O\nan O\naverage O\n7.4 O\ncm O\n( O\n2.96 O\ninches O\n) O\nper O\nmonth O\n-- O\nbut O\nin O\nseveral O\ncommunes O\nin O\nthe O\nsouth O\nof O\nthe O\ncountry O\nup O\nto O\n8 O\ncm O\n( O\n3.2 O\ninches O\n) O\nfell O\n, O\nthe O\nRoyal B-ORG\nMeteorological I-ORG\nInstitute I-ORG\n( O\nRMT B-ORG\n) O\nsaid O\n. O\n\nThe O\nRMT B-ORG\nspokesman O\nsaid O\nthat O\nnear O\nthe O\neastern O\ncity O\nof O\nTurnhout B-LOC\n, O\na O\ngroup O\nof O\nboy O\nscouts O\ncamping O\nin O\na O\nlow-lying O\nmeadow O\nhad O\nto O\nbe O\nevacuated O\nas O\nwater O\nflooded O\ntheir O\ntents O\n. O\n\nThe O\nrain O\nalso O\nseverely O\nhindered O\nBelgian B-MISC\ninvestigators O\n' O\nexcavations O\nin O\nthe O\nsouthern O\nvillage O\nof O\nJumet B-LOC\n, O\nwhere O\nthey O\nare O\nlooking O\nfor O\nbodies O\nin O\none O\nof O\nthe O\nhouses O\nof O\nthe O\nmain O\ncharacter O\nin O\na O\npaedophile O\nsex-and-murder O\nscandal O\n. O\n\nBut O\nthe O\ncoastal O\ntowns O\ngot O\noff O\nlightly O\nas O\nthe O\nflooding O\nthat O\nhad O\nbeen O\nexpected O\ndue O\nto O\na O\ncombination O\nof O\nspring O\ntides O\nand O\nhigh O\nwinds O\nfailed O\nto O\nmaterialise O\n. O\n\n-DOCSTART- O\n\nRepsol B-ORG\nshares O\nup O\n65 O\npesetas O\non O\nH1 O\nresults O\n. O\n\nMADRID B-LOC\n1996-08-29 O\n\nShares O\nin O\nSpanish B-MISC\noil O\nand O\nchemicals O\ngroup O\nRepsol B-ORG\nwere O\nup O\n65 O\npesetas O\nto O\n4,150 O\nafter O\nthe O\ncompany O\nannounced O\nnet O\nfirst O\nhalf O\nprofits O\nfell O\n1.1 O\npercent O\nto O\n61.45 O\nbillion O\npesetas O\non O\nthe O\nprevious O\nyear O\n. O\n\nThis O\nwas O\nclose O\nto O\nthe O\nmarket O\n's O\nforecast O\nof O\nnet O\nprofits O\nof O\n61.94 O\nbillion O\n. O\n\nShares O\nin O\nRepsol B-ORG\nshot O\nup O\n100 O\npesetas O\nto O\n4,175 O\nshortly O\nafter O\nthe O\nfigures O\n, O\nhaving O\ntraded O\ndown O\n10 O\npesetas O\nbefore O\nthe O\nfigures O\nwere O\nreleased O\n. O\n\n\" O\nIt O\n's O\nmadness O\n, O\n\" O\nsaid O\nan O\nanalyst O\nat O\na O\nMadrid B-LOC\nbrokerage O\n, O\nadding O\nthat O\nthe O\nmarket O\nhad O\noverreacted O\nto O\nthe O\nnews O\n. O\n\" O\n\nPeople O\nwere O\nwaiting O\nfor O\nthe O\nresults O\nto O\ncome O\nout O\nbefore O\nbuying O\n. O\n\nThe O\nrise O\nhas O\nbeen O\nvery O\nquick O\nand O\nvery O\ncrazy O\n. O\n\" O\n\nHe O\npredicted O\na O\ncorrection O\n, O\nperhaps O\nas O\nearly O\nas O\nthis O\nsession O\n. O\n\n-- O\nMadrid B-ORG\nNewsroom I-ORG\n+34 O\n1 O\n585 O\n2161 O\n\n-DOCSTART- O\n\nAlgeria B-LOC\nforces O\nkill O\nguerrillas O\n- O\npapers O\n. O\n\nPARIS B-LOC\n1996-08-29 O\n\nAlgerian B-MISC\nsecurity O\nforces O\nkilled O\nfour O\nMoslem B-MISC\nguerrillas O\non O\nTuesday O\nin O\na O\nvillage O\nsouth O\nof O\nthe O\ncapital O\nAlgiers B-LOC\n, O\nan O\nAlgerian B-MISC\nnewspaper O\nsaid O\non O\nThursday O\n. O\n\nThe O\narmed O\nmilitants O\nwere O\nshot O\ndead O\nin O\nNahar B-LOC\nvillage O\n90 O\nkm O\n( O\n56 O\nmiles O\n) O\nsouth O\nof O\nAlgiers B-LOC\n, O\nLiberte B-ORG\nnewspaper O\nsaid O\n. O\n\nSecurity O\nforces O\nalso O\nkilled O\nan O\nunspecified O\nnumber O\nof O\nmembers O\nof O\na O\nrebel O\ngang O\non O\nWednesday O\nin O\nthe O\nLeveilly B-LOC\nsuburb O\nof O\nAlgiers B-LOC\n, O\nLe B-ORG\nMatin I-ORG\nnewspaper O\nreported O\n. O\n\nAn O\nestimated O\n50,000 O\npeople O\n, O\nmostly O\nMoslem B-MISC\nmilitants O\nand O\nsecurity O\nforces O\nmembers O\n, O\nhave O\nbeen O\nkilled O\nin O\nviolence O\npitting O\nMoslem B-MISC\nguerrillas O\nagainst O\ngovernment O\nforces O\nsince O\nearly O\n1992 O\n, O\nwhen O\nauthorities O\ncancelled O\na O\ngeneral O\nelection O\nin O\nwhich O\nIslamists B-MISC\nhad O\ntaken O\na O\ncommanding O\nlead O\n. O\n\n-DOCSTART- O\n\nFinns B-MISC\nhold O\ntwo O\nmen O\non O\nchild O\nsex-abuse O\ncharges O\n. O\n\nHELSINKI B-LOC\n1996-08-29 O\n\nFinnish B-MISC\npolice O\nsaid O\non O\nThursday O\nthey O\nhad O\narrested O\ntwo O\nmen O\nsuspected O\nof O\nsexually O\nabusing O\na O\ncaptive O\n13-year-old O\ngirl O\n, O\nbut O\ndid O\nnot O\nbelieve O\nthe O\ncase O\nwas O\nlinked O\nto O\nothers O\nin O\nEurope B-LOC\n. O\n\nThe O\nmen O\n, O\nboth O\nFinns B-MISC\naged O\nabout O\n40 O\n, O\nwere O\narrested O\nlast O\nSaturday O\nin O\nthe O\nwestern O\ntown O\nof O\nTampere B-LOC\nin O\na O\nraid O\non O\na O\nluxury O\nboat O\nowned O\nby O\none O\nof O\nthem O\n. O\n\nThe O\ngirl O\nwas O\nbeing O\nheld O\non O\nthe O\nboat O\nand O\nhad O\nsought O\nhelp O\nfrom O\na O\npasser-by O\n, O\npolice O\nchief O\ninspector O\nIlkka B-PER\nLaasonen I-PER\nsaid O\n. O\n\n\" O\nThis O\nis O\nan O\nindividual O\ncase O\nand O\nI O\ndo O\nn't O\nhave O\nany O\nevidence O\nlinking O\nthe O\nsuspects O\nto O\nany O\nother O\ncases O\n, O\n\" O\nLaasonen B-PER\nsaid O\n. O\n\nThe O\ngirl O\nwas O\ntaken O\nto O\nhospital O\n. O\n\nThe O\nmen O\ncould O\nface O\ncharges O\ncarrying O\nup O\nto O\nsix O\nto O\n10 O\nyears O\nin O\nprison O\n, O\nhe O\nsaid O\n. O\n\nWitnesses O\nhad O\nreported O\nseeing O\nmany O\nyoung O\nwomen O\nand O\nsome O\ngirls O\nwho O\nlooked O\nclearly O\nunderage O\nat O\nparties O\naround O\nthe O\nboat O\nin O\nrecent O\nweeks O\n, O\nthe O\ndaily O\nnewspaper O\nIltalehti B-ORG\nsaid O\n. O\n\n-DOCSTART- O\n\nAudi B-ORG\nCEO O\nsays O\nexpects O\nno O\n96 O\ncurrency O\nimpact O\n. O\n\nINGOLSTADT B-LOC\n1996-08-29 O\n\nAudi B-ORG\nAG I-ORG\nmanagement O\nboard O\nchairman O\nHerbert B-PER\nDemel I-PER\nsaid O\non O\nThursday O\nthat O\nthe O\nGerman B-MISC\nluxury O\ncarmaker O\n, O\na O\nunit O\nof O\nVolkswagen B-ORG\nAG I-ORG\n, O\ndid O\nnot O\nexpect O\nany O\nburden O\non O\nits O\n1996 O\nresults O\nfrom O\ncurrency O\nmarket O\nvolatility O\n. O\n\n\" O\nWe O\ndo O\nnot O\nexpect O\nany O\nburden O\non O\nour O\n1996 O\nresults O\nfrom O\ncurrency O\nmarkets O\n, O\n\" O\nDemel B-PER\ntold O\nReuters B-ORG\nin O\nan O\ninterview O\n. O\n\nAudi B-ORG\nwould O\nhave O\nbeen O\nable O\nto O\nreport O\na O\nprofit O\n300 O\nmillion O\nmarks O\nhigher O\nin O\n1995 O\nif O\nexchange O\nrates O\nhad O\nstayed O\nthe O\nsame O\nas O\nin O\n1994 O\n, O\nDemel B-PER\nhad O\ntold O\na O\nshareholder O\nmeeting O\nlast O\nApril O\n. O\n\nDemel B-PER\nsaid O\nthe O\ncarmaker O\nhad O\nhedged O\nabout O\nhalf O\nof O\nits O\ncurrency O\nrisk O\nfor O\n1996 O\n. O\n\n-- O\nJohn B-PER\nGilardi I-PER\n, O\nFrankfurt B-ORG\nNewsroom I-ORG\n, O\n+49 O\n69 O\n756525 O\n\n-DOCSTART- O\n\nKEKKILA B-ORG\nSEES O\nFULL-YR O\n1996 O\nPROFIT O\nVS O\nLOSS O\n. O\n\nHELSINKI B-LOC\n1996-08-29 O\n\nFertilisers O\nand O\nsaplings O\nmaker O\nKekkila B-ORG\nOy I-ORG\nsaid O\non O\nThursday O\nin O\na O\nstatement O\nit O\nexpected O\na O\nfalling O\nresult O\ntrend O\nin O\nthe O\nlatter O\nhalf O\nof O\nthe O\nyear O\n, O\nbut O\na O\nfull-year O\nprofit O\nwas O\nnevertheless O\nlikely O\n. O\n\n\" O\nDue O\nto O\nnatural O\nseasonal O\nfluctuations O\nin O\noperations O\n, O\nthe O\nend-year O\nresult O\ntrend O\nwill O\nbe O\nfalling O\n, O\nbut O\nbased O\non O\nthe O\nearly O\nyear O\nresult O\ntrend O\na O\nprofitable O\nresult O\nis O\nlikely O\nto O\nbe O\nachieved O\n, O\n\" O\nKekkila B-ORG\nsaid O\nin O\nits O\nJanuary-June O\ninterim O\nreport O\n. O\n\nIn O\n1995 O\n, O\nKekkila B-ORG\nreported O\na O\n5.6 O\nmillion O\nmarkka O\nloss O\nbefore O\nextraordinary O\nitems O\nand O\ntax O\n. O\n\nIn O\nthe O\nfirst O\nhalf O\n, O\nKekkila B-ORG\nposted O\na O\n6.1 O\nmillion O\nmarkka O\nprofit O\n, O\nup O\nfrom O\n0.7 O\nmillion O\n. O\n\n-- O\nHelsinki B-ORG\nNewsroom I-ORG\n+358 O\n- O\n0 O\n- O\n680 O\n50 O\n245 O\n\n-DOCSTART- O\n\nINTERVIEW-T&N B-MISC\nuntroubled O\nby O\nmargin O\npressure O\n. O\n\nLONDON B-LOC\n1996-08-29 O\n\nThe O\nchairman O\nof O\nBritish-based B-MISC\ncomponents O\nand O\nengineering O\ngroup O\nT&N B-ORG\nPlc I-ORG\nsaid O\non O\nThursday O\nthe O\nfirm O\nremained O\nconfident O\nabout O\nthe O\ngeneral O\nprospects O\nfor O\nits O\noperating O\nmargins O\ndespite O\npressure O\nfrom O\nunsettled O\nmarkets O\n. O\n\nIn O\nan O\ninterview O\nfollowing O\nits O\nfirst-half O\nresults O\n, O\nwhich O\nincluded O\na O\nless O\noptimistic O\nforecast O\nfor O\nthe O\nsecond O\nhalf O\nof O\nthis O\nyear O\nthan O\nit O\nhad O\nmade O\nin O\nthe O\npast O\n, O\nSir O\nColin B-PER\nHope I-PER\nsaid O\nT&N B-ORG\nhad O\ntaken O\ndefensive O\naction O\nto O\nprotect O\nit O\nfrom O\npatchy O\nmarkets O\n. O\n\nLooking O\nat O\nmarket O\nprospects O\n, O\nhe O\nsaid O\n: O\n\" O\nI O\nthink O\nour O\nbest O\njudgment O\nat O\nthis O\nstage O\nis O\nthat O\nit O\nwill O\nprobably O\nbumble O\nalong O\nin O\nthe O\nrather O\nmixed O\nway O\nit O\n's O\nbeen O\nin O\nthe O\nfirst O\nhalf O\n. O\n\" O\n\n\" O\nIt O\n's O\nvery O\ndifficult O\nto O\npredict O\nthe O\nmarket O\n( O\ntrend O\n) O\nthis O\nyear O\n. O\n\nIt O\ncould O\nbe O\nbetter O\n, O\nor O\nit O\ncould O\nbe O\nworse O\n, O\n\" O\nHope B-PER\nadded O\n, O\nechoing O\nthe O\ndemand O\nuncertainty O\nacross O\nautomotive O\nindustries O\n. O\n\n\" O\nYou O\ncan O\nsee O\nanxieties O\nin O\nGermany B-LOC\nand O\nFrance B-LOC\n, O\nin O\nparticular O\n, O\nbeginning O\nto O\ngrow O\nand O\ndevelop O\n. O\n\nAmerica B-LOC\n, O\nhowever O\n, O\nis O\nlooking O\na O\nlittle O\nbetter O\n, O\n\" O\nhe O\nsaid O\n. O\n\nCompared O\nwith O\nthe O\nend O\nof O\nlast O\nyear O\n, O\nwhen O\nT&N B-ORG\npredicted O\na O\nsluggish O\nfirst O\nhalf O\nand O\na O\nrebound O\nlater O\nin O\n1996 O\n, O\nHope B-PER\nsaid O\n: O\n\" O\nI O\nthink O\nthe O\ndifference O\n( O\nnow O\n) O\nis O\nthe O\nfirst O\nhalf O\nhas O\nnot O\nactually O\nbeen O\nas O\nbad O\nas O\nsome O\nfelt O\nit O\nwas O\ngoing O\nto O\nbe O\n, O\nbut O\nequally O\nwe O\n're O\ncertainly O\nnot O\npredicting O\na O\nrecovery O\nin O\nthe O\nsecond O\nhalf O\n. O\n\" O\n\nAgainst O\nthis O\nbackground O\n, O\nHope B-PER\nsaid O\nthe O\ngroup O\nwas O\nglad O\nit O\nhad O\nrationalised O\nand O\ndestocked O\neven O\nthough O\nthis O\nhad O\npressed O\nmargins O\n, O\nwhich O\nhad O\nslipped O\nto O\n9.5 O\npercent O\nfrom O\n11.3 O\npercent O\na O\nyear O\nago O\n. O\n\n\" O\nI O\nthink O\nthe O\nfigure O\nof O\n9.5 O\npercent O\non O\nthe O\nfirst O\nhalf O\n, O\nwhen O\nyou O\nconsider O\nthe O\nfact O\nthat O\nwe O\n've O\nbeen O\ndestocking O\n, O\nthe O\nfairly O\nmixed O\ncustomer O\ndemand O\n, O\nand O\nthe O\nfact O\nthat O\nwe O\nsold O\nthe O\n( O\nsouthern O\nAfrican B-MISC\n) O\nmines O\nactually O\nis O\nnot O\nbad O\n. O\n\n\" O\nIt O\ndoes O\nshow O\nhow O\neasily O\nwe O\nshould O\nbe O\nable O\nto O\nbounce O\nback O\nover O\n10 O\npercent O\nagain O\n, O\n\" O\nhe O\nadded O\n, O\nsaying O\n: O\n\" O\nWe O\ncontinue O\nto O\nfeel O\nvery O\nrelaxed O\nabout O\nour O\ngeneral O\nview O\nthat O\nwe O\nwould O\naverage O\n10 O\npercent O\nprofit O\nmargins O\nover O\nthe O\ncycle O\n. O\n\" O\n\n\" O\nWe O\n've O\nalways O\ntaken O\nthe O\nview O\nthat O\nwe O\nare O\nthe O\nsort O\nof O\ncompany O\nthat O\n's O\nquite O\ncapable O\nof O\nworking O\nin O\ndifficult O\ncircumstances O\n-- O\nwe O\n're O\nrather O\nused O\nto O\nit O\n. O\n\nAnd O\nwe O\nfeel O\nvery O\nconfident O\nthat O\nwe O\n're O\ndoing O\nall O\nthe O\nright O\nthings O\n, O\n\" O\nHope B-PER\nsaid O\n. O\n\n\" O\nWhen O\nthe O\n( O\nprofit O\n) O\nfigures O\nwill O\nbounce O\nback O\nup O\nagain O\nis O\njust O\na O\nfunction O\nof O\nmarkets O\nrecovering O\njust O\na O\nfraction O\n, O\n\" O\nhe O\nadded O\n. O\n\nCommenting O\non O\nthe O\ncontinued O\nstruggle O\nto O\nget O\ncontrol O\nof O\nGerman B-MISC\npiston O\nmaker O\nKolbenschmidt B-ORG\n, O\nwhich O\nhas O\nbeen O\nhampered O\nby O\nregulatory O\nobstacles O\n, O\nHope B-PER\nsaid O\nT&N B-ORG\n's O\nconfidence O\n\" O\ncontinues O\nto O\nimprove O\n\" O\nthat O\nit O\nmay O\neventually O\nbe O\nable O\nto O\nproceed O\n. O\n\n-- O\nAndrew B-PER\nHuddart I-PER\n, O\nLondon B-ORG\nNewsroom I-ORG\n, O\n+44 O\n171 O\n542 O\n8716 O\n\n-DOCSTART- O\n\nEarthquake O\njolts O\nNew B-MISC\nZealands I-MISC\nSouth B-LOC\nIsland I-LOC\n. O\n\nWELLINGTON B-LOC\n1996-08-29 O\n\nAn O\nearthquake O\nmeasuring O\n5.5 O\non O\nthe O\nRichter B-PER\nscale O\nshook O\nNew B-MISC\nZealands I-MISC\nupper O\nSouth B-LOC\nIsland I-LOC\non O\nThursday O\nbut O\nthere O\nwere O\nno O\nreports O\nof O\ninjuries O\n, O\nTelevision B-ORG\nNew I-ORG\nZealand I-ORG\nsaid O\n. O\n\nIt O\nsaid O\nthe O\nquake O\n, O\ncentred O\nnear O\nthe O\nsmall O\ntown O\nof O\nWaiau B-LOC\n, O\nwas O\nstrongly O\nfelt O\nin O\nthe O\ncities O\nof O\nNelson B-LOC\nand O\nChristchurch B-LOC\n. O\n\nSome O\nminor O\ndamage O\nhad O\nbeen O\nreported O\nin O\nthe O\nspa O\ntown O\nof O\nHanmer B-LOC\n. O\n\nNew B-LOC\nZealand I-LOC\nis O\nprone O\nto O\nfrequent O\nearthquakes O\nbut O\nthey O\nrarely O\ncause O\nmajor O\ndamage O\n. O\n\nThe O\ncountry O\nhas O\nonly O\n3.5 O\nmillion O\npeople O\nin O\nan O\narea O\nabout O\nthe O\nsize O\nof O\nBritain B-LOC\nor O\nJapan B-LOC\n. O\n\n-DOCSTART- O\n\nHong B-LOC\nKong I-LOC\n's O\nTsang B-PER\nsees O\ngrowth O\n, O\nsmooth O\ntransition O\n. O\n\nMark B-PER\nTrevelyan I-PER\n\nWELLINGTON B-LOC\n1996-08-29 O\n\nHong B-LOC\nKong I-LOC\nFinancial O\nSecretary O\nDonald B-PER\nTsang I-PER\nsaid O\non O\nThursday O\nhe O\nexpected O\nthe O\nterritory O\n's O\neconomy O\nto O\nkeep O\ngrowing O\nat O\naround O\nfive O\npercent O\nbut O\nwith O\nsome O\nfluctuations O\nfrom O\nyear O\nto O\nyear O\n. O\n\nTsang B-PER\n, O\nwho O\nmade O\nthe O\nremarks O\nduring O\na O\nvisit O\nto O\nNew B-LOC\nZealand I-LOC\n, O\nalso O\nspoke O\nstrongly O\nin O\nfavour O\nof O\nkeeping O\nthe O\nHong B-LOC\nKong I-LOC\ndollar O\npegged O\nto O\nits O\nU.S. B-LOC\ncounterpart O\n, O\nand O\nsaid O\nnegotiations O\nwith O\nChina B-LOC\non O\nnext O\nyear O\n's O\nbudget O\nwere O\ngoing O\nsmoothly O\n. O\n\nHong B-LOC\nKong I-LOC\n's O\neconomy O\ngrew O\nby O\nonly O\n3.1 O\npercent O\nin O\nthe O\nfirst O\nquarter O\n, O\ndown O\nfrom O\n5.9 O\npercent O\na O\nyear O\nearlier O\n, O\nand O\nsome O\nprivate O\nsector O\neconomists O\nhave O\nrevised O\ndownwards O\ntheir O\npredictions O\nfor O\nthe O\n1996 O\nyear O\n. O\n\nSecond O\nquarter O\ngrowth O\nestimates O\nwill O\nbe O\nreleased O\nwhen O\nthe O\nHong B-LOC\nKong I-LOC\ngovernment O\nissues O\nits O\nhalf-yearly O\neconomic O\nreport O\non O\nFriday O\n. O\n\n\" O\nOur O\ntrend O\ngrowth O\nrate O\nof O\nfive O\npercent O\nin O\nreal O\nterms O\nis O\npretty O\nsolid O\n, O\n\" O\nTsang B-PER\ntold O\na O\nnews O\nconference O\nafter O\nmeeting O\nNew B-LOC\nZealand I-LOC\nFinance O\nMinister O\nBill B-PER\nBirch I-PER\n. O\n\n\" O\nThere O\nwill O\nbe O\nfluctuations O\nin O\nindividual O\nyears O\n, O\nbut O\nit O\nwo O\nn't O\nbe O\na O\nbig O\nmargin O\n, O\n\" O\nhe O\nsaid O\n. O\n\nHe O\nsaid O\ninflation O\nwas O\nunder O\ncontrol O\nand O\nthe O\nHong B-LOC\nKong I-LOC\ndollar O\nwas O\n\" O\nrock O\nsolid O\n\" O\n. O\n\nIts O\nlink O\nto O\nthe O\nU.S. B-LOC\ndollar O\nhad O\nproved O\nan O\nengine O\nof O\ngrowth O\nfor O\nthe O\npast O\n12 O\nyears O\n. O\n\n\" O\nThere O\n's O\nabsolutely O\nno O\neconomic O\nor O\nfinancial O\nor O\npolitical O\nreason O\nfor O\nus O\nto O\nchange O\n. O\n\nA O\nlot O\nof O\ninvestment O\nin O\nHong B-LOC\nKong I-LOC\n, O\nsome O\nof O\nwhich O\n( O\nis O\n) O\nby O\nChina B-LOC\n, O\nis O\npredicated O\non O\nthe O\nlink O\ncontinuing O\n. O\n\" O\n\nBritain B-LOC\nwill O\nhand O\nover O\nHong B-LOC\nKong I-LOC\nto O\nChinese B-MISC\nsovereignty O\nat O\nmidnight O\non O\nJune O\n30 O\n, O\n1997 O\n. O\n\nTsang B-PER\nsaid O\nthree O\nsets O\nof O\nmeetings O\nwith O\nChinese B-MISC\nauthorities O\non O\nHong B-LOC\nKong I-LOC\n's O\n1997-98 O\nbudget O\n, O\nwhich O\nwill O\nspan O\nthe O\ntransition O\nperiod O\n, O\nhad O\ngone O\nsmoothly O\n. O\n\" O\n\nNone O\nof O\nour O\nbasic O\nprecepts O\nhave O\nbeen O\nchallenged O\n. O\n\" O\n\nHong B-LOC\nKong I-LOC\nwill O\nretain O\nits O\nown O\ncurrency O\nafter O\nthe O\nhandover O\n, O\nrun O\nits O\nown O\nfinancial O\nand O\nmonetary O\npolicy O\nand O\nhave O\ncontrol O\nover O\nits O\nown O\nforeign O\nexchange O\nreserves O\n. O\n\nIt O\nwill O\nhave O\nno O\nduty O\nto O\ncontribute O\nany O\ntaxes O\nto O\nBeijing B-LOC\n, O\nTsang B-PER\nsaid O\n. O\n\nHe O\ndescribed O\nthe O\ncondition O\nof O\nthe O\nproperty O\nmarket O\nas O\n\" O\nvery O\ngood O\nindeed O\n\" O\n. O\n\n\" O\nYou O\nknow O\n, O\nwe O\nwent O\nthrough O\na O\nlittle O\nclimb O\nand O\na O\nlittle O\ntrough O\nover O\nthe O\nlast O\nfew O\nyears O\n. O\n\nBecause O\nof O\nspeculation O\nin O\nthe O\nmarket O\nwe O\nintroduced O\ncertain O\nmeasures O\n, O\nbut O\nthey O\nare O\nnot O\ndraconian O\nmeasures O\n, O\nand O\nwe O\nbrought O\nit O\ndown O\nto O\nearth O\n. O\n\" O\n\nTsang B-PER\nsaid O\nthe O\nmarket O\nwould O\ncontinue O\nto O\nappreciate O\nbecause O\nproperty O\nand O\nland O\nwere O\nscarce O\n. O\n\nThe O\ngovernment O\nwould O\nput O\nland O\non O\nthe O\nmarket O\nto O\nstop O\nrentals O\n\" O\ngoing O\nthrough O\nthe O\nroof O\n\" O\n, O\nbut O\nthis O\nwould O\nmean O\nreclamation O\n, O\nwith O\npossible O\nenvironmental O\nproblems O\n. O\n\n\" O\nThere O\nwill O\nbe O\non O\nthe O\nwhole O\na O\nslightly O\nupward O\nclimb O\n, O\nconsistent O\nwith O\nour O\neconomic O\ngrowth O\nrate O\n, O\n\" O\nhe O\nsaid O\nin O\nreference O\nto O\nthe O\nproperty O\nmarket O\n. O\n\nTsang B-PER\n, O\nthe O\nthird O\nsenior O\nfigure O\nin O\nthe O\ngovernment O\nafter O\nthe O\ngovernor O\nand O\nchief O\nsecretary O\n, O\nsaid O\nhis O\nstated O\naim O\nwas O\nto O\nserve O\nas O\nfinancial O\nsecretary O\nfor O\ntwo O\nyears O\nunder O\nBritish B-MISC\nrule O\nand O\nthree O\nyears O\nunder O\nChina B-LOC\n. O\n\n-DOCSTART- O\n\nTaiwan B-LOC\ndollar O\nends O\nhigher O\n, O\nnarrow O\ntrade O\nseen O\n. O\n\nTAIPEI B-LOC\n1996-08-29 O\n\nThe O\nTaiwan B-LOC\ndollar O\nclosed O\nslightly O\nfirmer O\non O\nThursday O\namid O\ntight O\nTaiwan B-LOC\ndollar O\nliquidity O\nin O\nthe O\nbanking O\nsystem O\n, O\nand O\ndealers O\nsaid O\nthe O\nrate O\nwas O\nlikely O\nto O\nmove O\nnarrowly O\nin O\nthe O\nnear O\nterm O\n. O\n\nThe O\nTaiwan B-LOC\ndollar O\nfell O\nin O\nearly O\ntrade O\non O\nmonth-end O\nU.S. B-LOC\ndollar O\ndemand O\n, O\nbut O\nthe O\ndowntrend O\nwas O\nlater O\nreversed O\nas O\nTaiwan B-LOC\ndollar O\nliquidity O\ntightened O\n. O\n\" O\n\nBanks O\ndo O\nnot O\nwant O\nto O\nhold O\nbig O\nU.S. B-LOC\ndollar O\npositions O\nat O\nthis O\nmoment O\n, O\n\" O\nsaid O\none O\ndealer O\n, O\nadding O\nthat O\nthe O\nrate O\nwas O\nlikely O\nto O\nhover O\naround O\ncurrent O\nlevels O\n. O\n\nThe O\nrate O\nclosed O\nat O\nT$ B-MISC\n27.482 O\nagainst O\nWednesday O\n's O\nT$ B-MISC\n27.495 O\n. O\n\nTurnover O\nwas O\nUS$ B-MISC\n275 O\nmillion O\n. O\n\n-- O\nJoyce B-PER\nLiu I-PER\n( O\n2-5080815 O\n) O\n\n-DOCSTART- O\n\nSIMEX B-MISC\nNikkei I-MISC\nends O\ndown O\nbut O\noff O\nlows O\n. O\n\nSINGAPORE B-LOC\n1996-08-29 O\n\nSimex B-MISC\nNikkei I-MISC\nfutures O\nended O\neasier O\nbut O\noff O\nthe O\nday O\n's O\nlows O\non O\nThursday O\n. O\n\nDealers O\nsaid O\nselling O\nin O\nthe O\nsession O\nwas O\na O\nfollow-through O\nfrom O\nWednesday O\n's O\ngloomy O\nTankan B-ORG\ncorporate O\nreport O\nby O\nthe O\nBank B-ORG\nof I-ORG\nJapan I-ORG\n. O\n\n\" O\nThe O\nNikkei B-MISC\nis O\ntesting O\nsupport O\nat O\nthe O\n20,500 O\nlevel O\n. O\n\nSentiment O\nis O\na O\nbit O\ngloomy O\nbecause O\npeople O\nare O\nfocusing O\non O\nthe O\nweak O\nrecovery O\nin O\nthe O\neconomy O\nat O\nthe O\nmoment O\n, O\n\" O\nsaid O\na O\ndealer O\nwith O\na O\nEuropean B-MISC\nbank O\n. O\n\nSeptember O\nNikkei B-MISC\nsettled O\nat O\n20,605 O\nafter O\ntouching O\nan O\nintraday O\nlow O\nof O\n20,530 O\nagainst O\nits O\nprevious O\nclose O\nof O\n20,725 O\n. O\n\nVolume O\nwas O\n19,560 O\ncontracts O\n. O\n\nDealers O\nsaid O\ntechnically O\n, O\nthe O\nindex O\nshould O\nsee O\ngood O\nsupport O\nat O\n20,300 O\nand O\nthe O\nupside O\nshould O\nbe O\ncapped O\nat O\n21,000 O\n. O\n\n-- O\nDoreen B-PER\nSiow I-PER\n65-8703092 O\n\n-DOCSTART- O\n\nSiam B-ORG\nCommercial I-ORG\nwins O\nagency O\nbond O\nauctions O\n. O\n\nBANGKOK B-LOC\n1996-08-29 O\n\nA O\nconsortium O\nled O\nby O\nThailand B-LOC\n's O\nSiam B-ORG\nCommercial I-ORG\nBank I-ORG\nPlc I-ORG\nhas O\nsecured O\nat O\nauction O\nthe O\nright O\nto O\nsell O\ntwo O\nstate O\nagency O\nbond O\nissues O\nworth O\na O\ncombined O\n3.73 O\nbillion O\nbaht O\n, O\nan O\nofficial O\nat O\nthe O\nbank O\nsaid O\non O\nThursday O\n. O\n\nThe O\nGovernment B-ORG\nHousing I-ORG\nBank I-ORG\nwill O\nissue O\nbonds O\nworth O\nthree O\nbillion O\nbaht O\nand O\nthe O\nmetropolitan O\nWaterworks B-ORG\nAuthority I-ORG\nwill O\nissue O\nbonds O\nworth O\n730 O\nmillion O\n, O\nan O\ninvestment O\nbanker O\nat O\nSiam B-ORG\nCommercial I-ORG\nBank I-ORG\ntold O\nReuters B-ORG\n. O\n\nThe O\nconsortium O\n, O\nmade O\nup O\nof O\neight O\nfinancial O\ninstitutions O\n, O\noffered O\nan O\nannual O\ninterest O\nrate O\nof O\n8.46 O\npercent O\nfor O\nboth O\nissues O\n, O\nhe O\nsaid O\n. O\n\nBoth O\nstate O\nagency O\nbonds O\nwill O\nhave O\nseven-year O\nmaturity O\nand O\nwill O\nbe O\nissued O\non O\nSeptember O\n5 O\n, O\nhe O\nsaid O\n. O\n\n-- O\nBangkok B-LOC\nnewsroom O\n( O\n662 O\n) O\n652-0642 O\n\n-DOCSTART- O\n\nM'bishi B-ORG\nGas I-ORG\nsets O\nterms O\non O\n7-year O\nstraight O\n. O\n\nTOKYO B-LOC\n1996-08-29 O\n\nBORROWER O\n- O\nMitsubishi B-ORG\nGas I-ORG\nChemical I-ORG\nCo I-ORG\nLtd I-ORG\n\nLEAD O\nMGR O\n- O\nNomura B-ORG\nSecurities I-ORG\nCo I-ORG\nLtd I-ORG\n\nFISCAL O\nAGENT O\n- O\nTokyo-Mitsubishi B-ORG\nBank I-ORG\n\nTYPE O\nstraight O\nbond O\nISSUE O\nNO O\n13 O\nAMT O\n10 O\nbln O\nyen O\n\nCOUPON O\n2.95 O\n% O\nISS O\nPRICE O\nMATURITY O\n5 O\n. O\n\nSep.03 O\n\nLAST O\nMOODY B-ORG\n'S I-ORG\nPAY O\nDATE O\n5 O\n. O\n\nSep.96 O\n\nFIRST O\nINT O\nPAY O\n5 O\n. O\n\nMar.97 O\nINT O\nPAY O\n5 O\n. O\n\nMar O\n/ O\nSep O\n\nLAST O\nS&P B-ORG\nSIGN O\nDATE O\nSUB O\nDATE O\n5 O\n. O\n\nJul-18.Jul O\n\nLAST O\nJCR O\nLAST O\nJBRI O\nA O\nLAST O\nNIS O\n\n-DOCSTART- O\n\nS. B-LOC\nKorea I-LOC\nDaewoo B-ORG\n, O\nDacom B-ORG\nunits O\nin O\nPolish B-MISC\ntelecom O\nJV O\n. O\n\nSEOUL B-LOC\n1996-08-29 O\n\nSouth B-LOC\nKorea I-LOC\n's O\nDaewoo B-ORG\nCorp I-ORG\n, O\nunlisted O\nDaewoo B-ORG\nInformation I-ORG\nSystems I-ORG\nCo I-ORG\nLtd I-ORG\n, O\nDacom B-ORG\nCorp I-ORG\nand O\nDacom B-ORG\nInternational I-ORG\nhave O\nset O\nup O\na O\njoint O\nventure O\nto O\noffer O\ntelecommunications O\nservices O\nin O\nPoland B-LOC\n. O\n\nDaewoo B-ORG\nDacom I-ORG\nCommunications I-ORG\n( O\nPoland B-LOC\n) O\nLtd B-ORG\n, O\nwhich O\nwas O\nset O\nup O\nwith O\nan O\ninitial O\ninvestment O\nof O\n$ O\n1.0 O\nmillion O\n, O\nis O\nexpected O\nto O\nhave O\nsales O\nof O\n$ O\n60 O\nmillion O\nby O\nthe O\nyear O\n2000 O\n, O\na O\nDaewoo B-ORG\nstatement O\nsaid O\non O\nThursday O\n.. O\n\nDaewoo B-ORG\nCorp I-ORG\nwill O\ntake O\na O\n31 O\npercent O\nstake O\nin O\nthe O\nventure O\n, O\nDacom B-ORG\nInternational I-ORG\n25 O\npercent O\n, O\nDacom B-ORG\n24 O\npercent O\n, O\nand O\nDaewoo B-ORG\nInformation I-ORG\n20 O\npercent O\n, O\nthe O\nstatement O\nsaid O\n. O\n\nDaewoo B-ORG\nCorp I-ORG\nand O\nDaewoo B-ORG\nInformation I-ORG\nare O\nunits O\nof O\nDaewoo B-ORG\nGroup I-ORG\n. O\n\n-- O\nSeoul B-ORG\nNewsroom I-ORG\n( O\n822 O\n) O\n727 O\n5644 O\n\n-DOCSTART- O\n\nSalomon B-ORG\n& I-ORG\nTaylor I-ORG\n- O\n96/97 O\ndiv O\nforecast O\n. O\n\nTOKYO B-LOC\n1996-08-29 O\n\nYear O\nto O\nMarch O\n31 O\n, O\n1997 O\n\n( O\nin O\nbillions O\nof O\nyen O\nunless O\nspecified O\n) O\n\nLATEST O\nACTUAL O\n\n( O\nParent O\n) O\nFORECAST O\nYEAR-AGO O\n\nOrd O\ndiv O\n10.00 O\nyen O\n8.00 O\nyen O\n\n- O\nCommem O\ndiv O\n- O\n2.00 O\nyen O\n\nNOTE O\n- O\nSalomon B-ORG\n& I-ORG\nTaylor I-ORG\nMade I-ORG\nCo I-ORG\nLtd I-ORG\nmanufactures O\ngolf O\nclubs O\nand O\nsells O\nski O\nequipment O\n. O\n\n-DOCSTART- O\n\nIndonesia B-LOC\nplays O\ndown O\nU.S. B-LOC\nconsulate O\nattack O\n. O\n\nJAKARTA B-LOC\n1996-08-29 O\n\nIndonesia B-LOC\nsought O\non O\nThursday O\nto O\nplay O\ndown O\na O\nfire O\nbomb O\nattack O\non O\na O\nU.S. B-LOC\nconsulate O\nearlier O\nthis O\nweek O\n, O\nsaying O\nit O\nwas O\nbeing O\ntreated O\nas O\na O\ncriminal O\nrather O\nthan O\na O\npolitical O\nact O\n, O\nthe O\nofficial O\nAntara B-LOC\nnews O\nagency O\nsaid O\n. O\n\nThe O\npolice O\nare O\nstill O\ninvestigating O\nthe O\nincident O\n. O\n\nIt O\nis O\nevident O\nthe O\nhappening O\nis O\nnot O\npolitically O\nmotivated O\nbut O\njust O\nan O\nordinary O\ncriminal O\nact O\n, O\nthe O\nnews O\nagency O\nquoted O\nEast B-MISC\nJava I-MISC\nmilitary O\ncommander O\nMajor-General O\nUtomo B-PER\nas O\nsaying O\n. O\n\nThe O\nTuesday O\nmorning O\nattack O\non O\nthe O\nconsulate O\nin O\nIndonesias B-MISC\nsecond O\nlargest O\ncity O\nof O\nSurabaya B-LOC\n, O\ncaused O\nslight O\ndamage O\nto O\na O\nguard O\nhouse O\nbefore O\nbeing O\nquickly O\nextinguished O\n, O\na O\nspokesman O\nat O\nthe O\nU.S. B-LOC\nembassy O\nin O\nJakarta B-LOC\n, O\n700 O\nkm O\n( O\n430 O\nmiles O\n) O\nwest O\nof O\nSurabaya B-LOC\n, O\nsaid O\non O\nWednesday O\n. O\n\nNo O\none O\nwas O\ninjures O\n, O\nhe O\nsaid O\n. O\n\nNobody O\nshould O\ntry O\nand O\nexaggerate O\nit O\nby O\ncalling O\nit O\na O\nbomb O\nbecause O\nit O\nwas O\njust O\na O\nmolotov O\ncocktail O\n, O\nUtomo B-PER\nsaid O\n. O\n\nHe O\nsaid O\npolice O\nwere O\ninvestigating O\nthe O\nincident O\nand O\npatrols O\naround O\ndiplomatic O\noffices O\nin O\nSurabaya B-LOC\nwould O\nbe O\nstepped O\nup O\n. O\n\n-DOCSTART- O\n\nAirport B-ORG\nFacilities I-ORG\n- O\n6mth O\nparent O\nforecast O\n. O\n\nTOKYO B-LOC\n1996-08-29 O\n\nSix O\nmonths O\nto O\nSeptember O\n30 O\n, O\n1996 O\n\n( O\nin O\nbillions O\nof O\nyen O\nunless O\nspecified O\n) O\n\nLATEST O\nPREVIOUS O\nACTUAL O\n\n( O\nParent O\n) O\nFORECAST O\nFORECAST O\nYEAR-AGO O\n\nSales O\n11.38 O\n11.38 O\n11.45 O\n\nCurrent O\n1.09 O\n1.09 O\n918 O\nmillion O\n\nNet O\n934 O\nmillion O\n490 O\nmillion O\n538 O\nmillion O\n\nNOTE O\n- O\nAirport B-ORG\nFacilities I-ORG\nCo I-ORG\nLtd I-ORG\nmanages O\nand O\nrents O\nfacilities O\nat O\nHaneda B-LOC\n( O\nTokyo B-LOC\n) O\nand O\nItami B-LOC\n( O\nOsaka B-LOC\n) O\nairports O\n. O\n\n-DOCSTART- O\n\nHK B-LOC\ncivil O\nservants O\ncontest O\nban O\non O\nChina B-LOC\npanel O\n. O\n\nHONG B-LOC\nKONG I-LOC\n1996-08-29 O\n\nSenior O\nHong B-LOC\nKong I-LOC\ncivil O\nservants O\nwere O\ngiven O\nthe O\ngo-ahead O\non O\nThursday O\nto O\nchallenge O\na O\ngovernment O\nban O\non O\nthem O\nstanding O\nfor O\nthe O\nBeijing-backed B-MISC\npanel O\nto O\nchoose O\nthe O\nterritory O\n's O\nfirst O\npost-handover O\nleader O\nand O\nlawmakers O\n. O\n\nThe O\nSupreme B-ORG\nCourt I-ORG\nruled O\nthat O\na O\njudicial O\nhearing O\ncontesting O\nthe O\nban O\nwould O\nbe O\nheard O\non O\nSeptember O\n11 O\n, O\nthree O\ndays O\nbefore O\nthe O\nnomination O\nperiod O\nfor O\nthe O\nSelection B-ORG\nCommittee I-ORG\ncloses O\n. O\n\nThe O\ngovernment O\nmaintains O\nthe O\nban O\n, O\nannounced O\nearlier O\nthis O\nmonth O\n, O\nis O\nnecessary O\nto O\navoid O\na O\npossible O\nconflict O\nof O\ninterest O\nbecause O\ncivil O\nservants O\nare O\ninvolved O\nin O\ndetermining O\ngovernment O\npolicy O\n. O\n\nCivil O\nservants O\nargue O\nthe O\nban O\nstymies O\ntheir O\npolitical O\nrights O\n. O\n\nThe O\n400-strong O\nSelection B-ORG\nCommittee I-ORG\nwill O\nselect O\nHong B-LOC\nKong I-LOC\n's O\nfuture O\nchief O\nexecutive O\nto O\nreplace O\nthe O\nBritish B-MISC\ngovernor O\nand O\na O\nprovisional O\nlegislature O\nto O\ntake O\nover O\nfrom O\nthe O\nelected O\nchamber O\nwhich O\nBeijing B-LOC\nplans O\nto O\ndissolve O\n. O\n\nHong B-LOC\nKong I-LOC\n, O\na O\nBritish B-MISC\ncolony O\nfor O\nmore O\nthan O\n150 O\nyears O\n, O\nwill O\nbe O\nhanded O\nback O\nto O\nChina B-LOC\nat O\nmidnight O\non O\nJune O\n30 O\nnext O\nyear O\n. O\n\nChina B-LOC\nintends O\nto O\ndismantle O\nthe O\nterritory O\n's O\nfirst O\nfully-elected O\nlegislature O\nbecause O\nit O\nopposes O\nBritain B-LOC\n's O\nrecent O\nelectoral O\nreforms O\nand O\ninstall O\nan O\ninterim O\nappointed O\nchamber O\n, O\na O\ndecision O\nthat O\nhas O\ngenerated O\nconsiderable O\ncontroversy O\n. O\n\nThe O\njudicial O\nreview O\nsought O\nby O\ndirectorate-grade O\nbureaucrats O\nwill O\napply O\nto O\nonly O\nabout O\n1,000 O\nof O\nthe O\napproximately O\n33,000 O\ncivil O\nservants O\naffected O\n. O\n\nPolice O\nunions O\nare O\nnot O\ncontesting O\nthe O\nban O\n, O\nwhich O\naffects O\nall O\n27,000 O\nofficers O\n, O\nand O\nnor O\nare O\nthe O\nvery O\ntop O\ntier O\nof O\nHong B-LOC\nKong I-LOC\n's O\nmandarin O\nclass O\n, O\nthe O\npolicy O\nsecretaries O\n. O\n\nMore O\nthan O\n16,000 O\napplication O\nforms O\nfor O\nplaces O\non O\nthe O\nSelection B-ORG\nCommittee I-ORG\nhave O\nbeen O\nhanded O\nout O\nsince O\nthe O\nnomination O\nperiod O\nopened O\n. O\n\nIt O\ncloses O\non O\nSeptember O\n14 O\n. O\n\n-DOCSTART- O\n\nSingapore B-ORG\nRefining I-ORG\nCompany I-ORG\nexpected O\nto O\nshut O\nCDU B-ORG\n3 I-ORG\n. O\n\nSINGAPORE B-LOC\n1996-08-29 O\n\nSingapore B-ORG\nRefining I-ORG\nCompany I-ORG\n( O\nSRC B-ORG\n) O\nis O\nexpected O\nto O\nshutdown O\nits O\n60,000 O\nbarrel-per-day O\n( O\nbpd O\n) O\ncrude O\ndistillation O\nunit O\n( O\nCDU B-ORG\n) O\nin O\nSeptember O\n, O\nan O\nindustry O\nsource O\nsaid O\non O\nThursday O\n. O\n\n\" O\nThey O\nthink O\nsomething O\nis O\nstuck O\n, O\n\" O\nthe O\nsource O\nsaid O\n. O\n\" O\n\nBut O\nnothing O\nhas O\nbeen O\ndecided O\nas O\nthey O\nare O\nstill O\nwaiting O\nfor O\nan O\nX-ray O\nmachine O\nto O\ndetermine O\nthe O\nproblem O\n. O\n\" O\n\nThe O\nsource O\nsaid O\nthe O\nproblem O\nwas O\ndiscovered O\nduring O\nthe O\npast O\nmonth O\nduring O\nwhich O\ntime O\nCDU B-ORG\nNo.3 I-ORG\n's O\nproduction O\nhas O\nvaried O\nfrom O\nmaximum O\ncapacity O\nof O\n60,000 O\nbpd O\nto O\nas O\nlow O\nas O\n40,000 O\nbpd O\n, O\ndepending O\non O\nthe O\ncrude O\nbeing O\nrun O\n. O\n\n\" O\nWe O\nare O\nhaving O\na O\nlot O\nof O\nproblems O\n, O\n\" O\nsaid O\na O\nsource O\n. O\n\nAn O\nearlier O\nproblem O\nwith O\nCDU B-ORG\nNo I-ORG\n. I-ORG\n\n3 B-ORG\narose O\non O\nJuly O\n24 O\nwhen O\nan O\nindustry O\nsource O\nsaid O\nthe O\nCDU B-ORG\nwould O\nbe O\nclosed O\ndown O\nbriefly O\nin O\nAugust O\nfor O\nrepairs O\nto O\na O\nheat O\nexchanger O\n. O\n\nBut O\nby O\nmid-August O\n, O\na O\ncompany O\nspokesman O\nsaid O\nrepairs O\nhad O\nbeen O\ncarried O\nout O\nwithout O\nany O\nshutdown O\n. O\n\nThe O\n285,000 O\nbpd O\nSRC B-ORG\nrefinery O\nis O\nco-owned O\nby O\nthe O\nSingapore B-ORG\nPetroleum I-ORG\nCompany I-ORG\n, O\nBritish B-ORG\nPetrolem I-ORG\nand O\nCaltex B-ORG\n, O\nthe O\njoint-venture O\nof O\nU.S. B-LOC\nmajors O\nChevron B-ORG\nCorp I-ORG\nand O\nTexaco B-ORG\nInc I-ORG\n. O\n\n-- O\nSingapore B-ORG\nNewsroom I-ORG\n( O\n+65-8703086 O\n) O\n\n-DOCSTART- O\n\nLoxley B-ORG\nH1 O\nnet O\nrises O\nto O\n332.66 O\nmln O\nbaht O\n. O\n\nBANGKOK B-LOC\n1996-08-29 O\n\nReviewed O\nfinancial O\nresults O\nfor O\nthe O\nfirst O\nsix O\nmonths O\nended O\nJune O\n30 O\n, O\n1996 O\n. O\n\n( O\nin O\nmillions O\nof O\nbaht O\nunless O\nstated O\n) O\n\nSix O\nmonths O\n\n1996 O\n1995 O\n\nShr O\n( O\nbaht O\n) O\n8.32 O\nvs O\n6.66 O\n\nNet O\n332.66 O\nvs O\n266.37 O\n\nNOTES O\n: O\nSecond O\nquarter O\nfigures O\nnot O\navailable O\n. O\n\nFull O\nname O\nof O\ncompany O\nis O\nLoxley B-ORG\nPublications I-ORG\nPlc I-ORG\n. O\n\n-- O\nBangkok B-LOC\nnewsroom O\n662-252-9950 O\n\n-DOCSTART- O\n\nINDICATORS O\n- O\nSpain B-LOC\n- O\nupdated O\nAugust O\n29 O\n. O\n\nINDICATORS O\n- O\nmonthly O\nMTH O\n/ O\nMTH O\nPVS O\nYR-AGO O\nINDEX O\nTOTAL O\n\nCPI O\n( O\n% O\n) O\nJul O\n+0.1 O\n- O\n0.1 O\n+0.0 O\n119.3** O\n- O\n\nYr O\n/ O\nyr O\nInflation O\n( O\n% O\n) O\n+3.7 O\n+3.6 O\n+4.7 O\n119.3 O\n- O\n\nCore O\nInflation O\n+0.1 O\n+0,2 O\n+0,2 O\n- O\n- O\n\nYr O\n/ O\nyr O\nrise O\n+3.5 O\n+3.6 O\n+5.2 O\n- O\n- O\n\nJOBLESS O\n( O\nINEM O\n) O\nJul O\n- O\n63,913 O\n- O\n33,149 O\n- O\n65,345 O\n- O\n2.17M O\n\nRate O\n( O\n% O\n) O\n13.67 O\n14.15 O\n15.19 O\n- O\n- O\n\nBALANCE O\nOF O\nPAYMENTS O\n\nTrade O\n( O\nbln O\npts O\n) O\nMay O\n- O\n196.8 O\n- O\n180.6 O\n- O\n279.9 O\n- O\n- O\n\nCur O\nAcc O\n( O\nbln O\npts O\n) O\nMay O\n- O\n9.5 O\n- O\n42.0 O\n- O\n110.4 O\n- O\n- O\n\nRESERVES O\n( O\n$ O\nMLN O\n) O\nJul O\n+1,161 O\n+400.9 O\n+310.4 O\n- O\n54,703.0 O\n\nPRODUCER O\nPRICES O\n( O\n% O\n) O\nJun O\n- O\n0.2 O\n+0.1 O\n+0.2 O\n119.6** O\n- O\n\nYr O\n/ O\nyr O\nrise O\n( O\n% O\n) O\n+1.2 O\n+1.5 O\n+7.1 O\n119.6 O\n- O\n\nINDUSTRIAL O\nPROD O\n. O\n\nMay O\n- O\n- O\n- O\n- O\n- O\n\nYr O\n/ O\nyr O\nfigures O\n( O\n% O\n) O\n- O\n3.2 O\n+1.0 O\n+9.8 O\n108.4** O\n- O\n\nM4 O\nMONEY O\nSUPPLY O\n( O\n% O\n) O\nJul O\n+2.6 O\n+4.2R O\n+10.8 O\n- O\n- O\n\nTotal O\nM4 O\nadj O\n. O\n\n( O\ntrln O\npts O\n) O\n- O\n- O\n- O\n- O\n75.912 O\n\nTRADE O\nBALANCE O\n\nExports O\n( O\nbln O\npts O\n) O\nJun O\n1,100.7 O\n1,164.1 O\n988.2 O\n- O\n- O\n\nImports O\n( O\nbln O\npts O\n) O\nMay O\n1,315.7 O\n1,433.4 O\n1,236.5 O\n- O\n- O\n\nDeficit O\n/ O\nsurplus O\nMay O\n- O\n215.0 O\n- O\n269.3 O\n- O\n248.3 O\n- O\n- O\n\nDeficit O\nyr O\nto O\ndate O\n- O\n1,334.0 O\n- O\n1,119.0 O\n- O\n1,420.9 O\n- O\n- O\n\nGOVT.BUDGET O\n( O\nbln O\npts O\n) O\nGovt.Fcast O\n96 O\n\nDeficit O\n/ O\nsurplus O\nJul O\n+282.1 O\n- O\n380.6 O\n+230.4 O\n- O\n\nDef O\n. O\n\n/ O\nsurplus O\nto O\ndate O\n- O\n1,184.0 O\n- O\n1,466.1 O\n- O\n1,456.7 O\n- O\n2.6 O\ntrln O\n\nINDICATORS O\n- O\nquarterly O\nQUARTER O\nPVS O\nQTR O\nYR-AGO O\n- O\n- O\n\nEPA O\nQ2 O\n+168,130 O\n+31,230 O\n+167,330 O\n12.3 O\nmillion O\n\nGDP O\n\nYr-yr O\n( O\n% O\n) O\nQ1 O\n+1.9 O\n+2.3R O\n+3.4 O\n- O\n- O\n\nAbsolute O\namount O\n( O\ntrln O\npts O\n) O\n18.1 O\n17.8 O\n16.9 O\n- O\n69.7 O\n\nINTEREST O\nRATES O\nLatest O\nrate O\nPvs O\nrate O\nDate O\nchanged O\n\nKey O\nrate O\n( O\n% O\n) O\n7.25 O\n7.50 O\n04/06/96 O\n\nNOTES O\n- O\nBank B-ORG\nof I-ORG\nSpain I-ORG\nannounces O\nbalance O\nof O\npayments O\n. O\n\nJobless O\nfigures O\nare O\nregistered O\nunemployed O\nat O\nlabour O\nministry O\n. O\n\nTrade O\ndata O\nare O\ncustoms-cleared O\n, O\npublished O\nby O\neconomy O\nministry O\n. O\n\nLatest O\nM4 O\n, O\ncurrency O\nreserves O\n, O\nindustrial O\nproduction O\ndata O\nare O\nprovisional O\n. O\n\nGDP O\nfigures O\nare O\nquarterly O\non O\nannualised O\nbasis O\n. O\n\nEPA B-ORG\n- O\nQuarterly O\nsurvey O\nof O\nemployment O\nlevels O\n( O\nINE O\n) O\n. O\n\nData O\ngive O\nvariation O\nin O\nemployed O\npersons O\n, O\nin O\nthousands O\n. O\n\nLast O\ncolumn O\n- O\nTOTAL- O\nis O\nlatest O\nfor O\njobless O\nand O\naccumulated O\nfor O\nthe O\nrest O\n( O\nGDP O\ntotal O\namount O\ncorresponds O\nto O\n1995 O\n) O\n. O\n\nGovernment O\nbudget O\nfigures O\nrelate O\nto O\ncentral O\ngovernment O\nfinances O\nonly O\n. O\n\n**General B-MISC\nConsumer I-MISC\nPrice I-MISC\nIndex I-MISC\n( O\n100=1992 O\n) O\n, O\nProducer B-MISC\nPrices I-MISC\nIndex I-MISC\nand O\nIndustrial B-MISC\nProduction I-MISC\nIndex I-MISC\n( O\n100=1990 O\n) O\n. O\n\n-DOCSTART- O\n\nPRESS O\nDIGEST O\n- O\nSpain B-LOC\n- O\nAug O\n29 O\n. O\n\nHeadlines O\nfrom O\nmajor O\nnational O\nnewspapers O\n. O\n\nReuters B-ORG\nhas O\nnot O\nverified O\nthese O\nstories O\nand O\ndoes O\nnot O\nvouch O\nfor O\ntheir O\naccuracy O\n. O\n\nEL B-ORG\nPAIS I-ORG\n\n- O\nJudge O\naccuses O\ngovernment O\nof O\nobstructing O\ninvestigation O\ninto O\nLasa-Zabala B-PER\n( O\ntwo O\nof O\nGAL B-ORG\nvictims O\n) O\ncase O\n\nEL B-ORG\nMUNDO I-ORG\n\n- O\nGovernment O\nwants O\nto O\ncharge O\nfor O\nprescriptions O\nand O\nsome O\nmedical O\nservices O\n\nDIARIO B-ORG\n16 I-ORG\n\n- O\nJudge O\nJavier B-PER\nGomez I-PER\nde I-PER\nLiano I-PER\nsays O\ngovernment O\nis O\nobstructing O\njustice O\n\nABC B-ORG\n\n- O\nPrime O\nMinister O\nJose B-PER\nMaria I-PER\nAznar I-PER\n, O\npositive O\nassessment O\n\nCINCO B-ORG\nDIAS I-ORG\n\n- O\nBCH B-ORG\nin O\nthe O\nhive O\nof O\nChilean B-MISC\npensions O\n\nEXPANSION B-ORG\n\n- O\nCoopers B-ORG\nand I-ORG\nLybrand I-ORG\nemigrates O\nto O\nBasque B-LOC\nCountry I-LOC\nfor O\nfiscal O\nreasons O\n\nGACETA B-ORG\nDE I-ORG\nLOS I-ORG\nNEGOCIOS I-ORG\n\n- O\nGovernment O\nand O\nCatalan B-MISC\nnationalists O\nset O\nthe O\nscene O\nfor O\nbudget O\nnegotiations O\n\n-DOCSTART- O\n\nLenzing B-ORG\nexpects O\nnegative O\nresults O\nin O\nH2 O\n. O\n\nVIENNA B-LOC\n1996-08-29 O\n\nAustrian B-MISC\nviscose O\nfibre O\nmaker O\nLenzing B-ORG\nAG I-ORG\nsaid O\non O\nThursday O\nit O\nexpected O\nto O\npost O\nnegative O\ngroup O\nresults O\nin O\nthe O\nsecond O\nhalf O\nof O\nthe O\nyear O\nafter O\nposting O\nlosses O\nin O\nthe O\nfirst O\nsix O\nmonths O\n. O\n\n\" O\nA O\npreview O\nof O\nthe O\nsecond O\nhalf O\nof O\n1996 O\ndoes O\nnot O\nreveal O\nany O\nsigns O\nof O\na O\nsignificant O\nimprovement O\nin O\nmarket O\nconditions O\n, O\n\" O\nLenzing B-ORG\nsaid O\nin O\na O\nstatement O\nreleased O\nahead O\nof O\nits O\nearnings O\nconference O\n. O\n\nFor O\nthe O\nfirst O\nsix O\nmonths O\nof O\nthe O\nyear O\n, O\nLenzing B-ORG\nsaid O\nit O\nposted O\na O\ngroup O\npre-tax O\nloss O\nof O\n84.5 O\nmillion O\nschillings O\nfrom O\na O\nprofit O\nof O\n160 O\nmillion O\nin O\nthe O\nyear-ago O\nperiod O\n. O\n\nThe O\ngroup O\nattributed O\nthe O\nfirst-half O\nlosses O\nto O\nweak O\ndemand O\nand O\nfalling O\nprices O\nof O\nviscose O\nfibres O\n, O\nas O\nwell O\nas O\nsluggish O\neconomies O\nin O\nthe O\nWest B-LOC\n. O\n\n-- O\nJulia B-PER\nFerguson I-PER\n, O\nVienna B-LOC\nnewsroom O\n, O\n+431 O\n53112 O\n274 O\n\n-DOCSTART- O\n\nAlgeria B-LOC\nfaults O\nBritain B-LOC\nover O\nIslamists B-MISC\ngathering O\n. O\n\nPARIS B-LOC\n1996-08-28 O\n\nAlgeria B-LOC\n, O\nfighting O\na O\nvicious O\nwar O\nagainst O\nMoslem B-MISC\nfundamentalist O\nguerrillas O\n, O\nattacked O\nBritain B-LOC\non O\nWednesday O\nfor O\nallowing O\nIslamist B-MISC\ngroups O\nto O\nmeet O\nin O\nLondon B-LOC\n. O\n\nThe O\nIslamist B-MISC\ngathering O\n, O\ndue O\nto O\nbe O\nheld O\nin O\nLondon B-LOC\non O\nSeptember O\n8 O\n, O\nhas O\ntriggered O\nconcern O\nand O\nanger O\nin O\nseveral O\nother O\nArab B-MISC\ncountries O\nlike O\nEgypt B-LOC\nwhich O\nis O\nalso O\nfighting O\narmed O\nMoslem B-MISC\nfundamentalists O\n. O\n\nBritish B-MISC\nJewish I-MISC\ngroups O\nhave O\nalso O\nvoiced O\nprotest O\nbecause O\nthey O\nsaid O\nPalestinian B-MISC\nIslamist I-MISC\nHamas B-ORG\nas O\nwell O\nas O\nthe O\nbanned O\nAlgerian B-MISC\nIslamic B-ORG\nSalvation I-ORG\nFront I-ORG\n( O\nFIS B-ORG\n) O\nare O\namong O\nthose O\nradical O\nIslamists B-MISC\nattending O\nthe O\nconference O\n. O\n\nA O\nforeign O\nministry O\nspokesman O\nsaid O\nin O\na O\nstatement O\nread O\non O\nAlgerian B-MISC\ntelevision O\nthat O\nAlgeria B-LOC\n\" O\nhas O\nreceived O\nwith O\nconcern O\nthe O\ninformation O\nover O\na O\nmeeting O\nof O\nterrorist O\ngroups O\nworking O\nagainst O\nthe O\ninterests O\nof O\nthe O\nArab B-MISC\nand O\nIslamic B-MISC\nworld O\n. O\n\" O\n\n\" O\nAlgeria B-LOC\nexpresses O\nits O\nsharp O\nrejection O\nof O\na O\nmeeting O\nputting O\ntogether O\nmasterminds O\nand O\nideologists O\nand O\nfinancers O\nof O\nterrorism O\n, O\n\" O\nthe O\nspokesman O\nsaid O\n, O\nadding O\nthe O\nAlgerian B-MISC\ngovernment O\nhas O\nasked O\nthe O\nBritish B-MISC\nembassy O\nin O\nAlgiers B-LOC\nfor O\nclarifications O\n. O\n\nThe O\nAlgerian B-MISC\nambassador O\nin O\nLondon B-LOC\nhas O\nalso O\nasked O\nfor O\nclarification O\nfrom O\nthe O\nForeign B-ORG\nOffice I-ORG\nover O\nthe O\nmeeting O\nof O\nIslamist B-MISC\ngroups O\n. O\n\nAlgeria B-LOC\nsaid O\n\" O\nthey O\nare O\nclearly O\nworking O\nto O\nundermine O\nthe O\nstability O\n\" O\nof O\nArab B-MISC\ncountries O\n. O\n\nBritish B-MISC\nForeign O\nSecretary O\nMalcolm B-PER\nRifkind I-PER\nsaid O\non O\nTuesday O\nfrom O\nPakistan B-LOC\nhis O\ngovernment O\nwould O\nonly O\ntake O\naction O\nagainst O\nthe O\nplanned O\nIslamists B-MISC\ngathering O\nin O\nLondon B-LOC\nif O\nBritish B-MISC\nlaw O\nwas O\nbroken O\n. O\n\n\" O\nPeople O\nwho O\nwish O\nto O\nhold O\nconferences O\nof O\ncourse O\ndo O\nn't O\nneed O\nto O\nseek O\npermission O\nfrom O\nthe O\ngovernment O\nin O\nBritain B-LOC\n, O\n\" O\nhe O\nsaid O\n. O\n\nAn O\nestimated O\n50,000 O\npeople O\n, O\nincluding O\nmore O\nthan O\n110 O\nforeigners O\n, O\nhave O\nbeen O\nkilled O\nin O\nAlgeria B-LOC\n's O\nviolence O\npitting O\nMoslem B-MISC\nrebels O\nagainst O\ngovernment O\nforces O\nsince O\nearly O\n1992 O\nwhen O\nauthorities O\nin O\nAlgeria B-LOC\ncancelled O\na O\ngeneral O\nelection O\nin O\nwhich O\nFIS B-ORG\nhad O\ntaken O\na O\ncommanding O\nlead O\n. O\n\n-DOCSTART- O\n\nOFFICIAL B-ORG\nJOURNAL I-ORG\nCONTENTS O\n- O\nOJ B-ORG\nL O\n218 O\nOF O\nAUGUST O\n28 O\n, O\n1996 O\n. O\n\n* O\n\nCommission B-MISC\nRegulation I-MISC\n( O\nEC B-ORG\n) O\nNo B-MISC\n1676/96 I-MISC\nof O\n30 O\nJuly O\n1996 O\namending O\nRegulation B-MISC\n( O\nEEC B-ORG\n) O\nNo B-MISC\n2454/93 I-MISC\nlaying O\ndown O\nprovisions O\nfor O\nthe O\nimplementation O\nof O\nCouncil B-MISC\nRegulation I-MISC\n( O\nEEC B-ORG\n) O\nNo B-MISC\n2913/92 I-MISC\nestablishing O\nthe O\nCommunity B-MISC\nCustoms I-MISC\nCode I-MISC\nEND O\nOF O\nDOCUMENT O\n. O\n\n-DOCSTART- O\n\nWall B-LOC\nStreet I-LOC\nponders O\nRubin B-PER\n's O\nrole O\nif O\nClinton B-PER\nwins O\n. O\n\nDonna B-PER\nSells I-PER\n\nNEW B-LOC\nYORK I-LOC\n\nThe O\noutcome O\nof O\nthe O\nNovember O\nelections O\nemerged O\nas O\na O\nhot O\ntopic O\non O\nWall B-LOC\nStreet I-LOC\nthis O\nweek O\nas O\nfinancial O\npundits O\ndebated O\nwhether O\nRobert B-PER\nRubin I-PER\nmight O\nforgo O\na O\nsecond O\nterm O\nas O\nTreasury B-ORG\nsecretary O\nif O\nPresident O\nClinton B-PER\nis O\nre-elected O\n. O\n\nConcern O\ncentred O\non O\nthe O\ncurrency O\nmarkets O\nsince O\nRubin B-PER\n's O\ntour O\nde O\nforce O\nhas O\nbeen O\nhis O\nunflagging O\nsupport O\nof O\nthe O\ndollar O\n. O\n\nSpeculation O\nthat O\nRubin B-PER\nmight O\nnot O\nstay O\nin O\nhis O\npost O\ngrew O\nafter O\nhe O\nsidestepped O\nquestions O\nabout O\nany O\nfuture O\nCabinet B-ORG\npost O\nduring O\ntelevision O\ninterviews O\nat O\nthe O\nDemocratic B-MISC\nconvention O\nin O\nChicago B-LOC\nthis O\nweek O\n. O\n\nShould O\nRubin B-PER\nleave O\n, O\nWall B-LOC\nStreet I-LOC\nwould O\nworry O\nthat O\nhe O\nmight O\ntake O\nhis O\nstrong-dollar O\npolicy O\nwith O\nhim O\n. O\n\nRubin B-PER\n's O\npredecessor O\nat O\nthe O\nTreasury B-ORG\n, O\nLloyd B-PER\nBentsen I-PER\n, O\nwas O\nviewed O\nwith O\nsuspicion O\nby O\nsome O\nin O\nthe O\nfinancial O\nmarkets O\nwho O\nthought O\nhe O\nhad O\ntried O\nto O\npush O\ndown O\nthe O\ndollar O\nto O\ngain O\nan O\nedge O\nin O\ntrade O\nnegotiations O\nwith O\nJapan B-LOC\n. O\n\n\" O\nObviously O\n, O\nunder O\nthe O\nClinton B-PER\nadministration O\n, O\nwe O\n've O\nseen O\ntwo O\ndistinctively O\ndifferent O\ndollar O\npolicies O\n, O\n\" O\nsaid O\nChris B-PER\nWidness I-PER\n, O\nan O\ninternational O\neconomist O\nat O\nChase B-ORG\nSecurities I-ORG\nInc. I-ORG\n\" O\nUnder O\nRubin B-PER\n, O\nthe O\nU.S. B-LOC\nhas O\ncertainly O\nlooked O\nfor O\na O\nstrong O\ndollar O\n. O\n\" O\n\nThat O\nstrategy O\n, O\nbacked O\nup O\nby O\ntimely O\ninstances O\nof O\njoint O\ncentral O\nbank O\nintervention O\n, O\nhelped O\nthe O\ndollar O\nbattle O\nback O\nfrom O\npost-Second B-MISC\nWorld I-MISC\nWar I-MISC\nlows O\nof O\n1.3438 O\nGerman B-MISC\nmarks O\non O\nMarch O\n8 O\n, O\n1995 O\n, O\nand O\n79.75 O\nJapanese B-MISC\nyen O\non O\nApril O\n19 O\n, O\n1995 O\n. O\n\nCurrently O\n, O\nthe O\ndollar O\nstands O\nat O\nabout O\n1.48 O\nmarks O\nand O\n109 O\nyen O\n. O\n\nRubin B-PER\nwas O\nwidely O\nhailed O\nas O\nthe O\narchitect O\nof O\nthe O\ndollar O\n's O\ncomeback O\n, O\nusing O\nskills O\nand O\nexpertise O\ngained O\nin O\n26 O\nyears O\non O\nWall B-LOC\nStreet I-LOC\n, O\npart O\nof O\nwhich O\nwere O\nspent O\nas O\nco-chairman O\nof O\nGoldman B-ORG\n, I-ORG\nSachs I-ORG\nand I-ORG\nCo I-ORG\n. I-ORG\n\nInc B-ORG\n. O\n\n\" O\nRubin B-PER\nhas O\ndone O\na O\nfine O\njob O\nin O\nthat O\nposition O\n, O\n\" O\nsaid O\nMichael B-PER\nFaust I-PER\n, O\na O\nportfolio O\nmanager O\nat O\nBailard B-ORG\n, I-ORG\nBiehl I-ORG\nand I-ORG\nKaiser I-ORG\n, O\nwhich O\nmanages O\njust O\nunder O\n$ O\n1 O\nbillion O\nin O\nglobal O\nstocks O\nand O\nbonds O\n. O\n\n\" O\nAnyone O\nwho O\nwould O\ncome O\nin O\nthere O\nto O\nreplace O\nhim O\nwould O\nhave O\nawfully O\nbig O\nshoes O\nto O\nfill O\n. O\n\" O\n\nFear O\nthat O\na O\nnew O\nTreasury B-ORG\nsecretary O\nmight O\nfavour O\na O\nreturn O\nto O\nBentsen-era B-MISC\npolicy O\ncould O\nspell O\ntrouble O\nfor O\nfinancial O\nmarkets O\n. O\n\nSome O\noverseas O\ninvestors O\nmight O\nshy O\naway O\nfrom O\nbuying O\nU.S. B-LOC\nstocks O\nand O\nbonds O\nor O\neven O\nsell O\nthem O\nwhen O\nthe O\ndollar O\nis O\nweakening O\n. O\n\nAs O\nfor O\nU.S. B-ORG\nTreasury I-ORG\nsecurities O\n, O\nWidness B-PER\nexplained O\nthat O\nAlan B-PER\nGreenspan I-PER\n's O\nreappointment O\nas O\nchairman O\nof O\nthe O\nFederal B-ORG\nReserve I-ORG\nand O\nthe O\noutlook O\nfor O\nthe O\nfederal O\nbudget O\nwere O\nmore O\nimportant O\nthan O\nwhether O\nRubin B-PER\ncontinues O\nat O\nthe O\nTreasury B-ORG\n. O\n\n\" O\nAlthough O\n, O\nif O\nwe O\ndid O\nget O\nsomeone O\nthat O\nwas O\nseen O\nas O\nlooking O\nfor O\na O\ndollar O\ndepreciation O\n, O\nit O\nwould O\nprobably O\nhurt O\ncapital O\nflows O\nto O\nthe O\nUnited B-LOC\nStates I-LOC\n, O\n\" O\nsaid O\nWidness B-PER\n, O\nadding O\nthat O\ncould O\nhurt O\nU.S. B-LOC\nstocks O\nand O\n, O\nto O\na O\nlesser O\ndegree O\n, O\nbonds O\n. O\n\nStill O\n, O\nmarkets O\nmay O\nhave O\nlittle O\nto O\nfear O\nfrom O\nany O\nRubin B-PER\nsuccessor O\nbecause O\nthe O\nfirm O\ndollar O\npolicy O\nhas O\nyielded O\npositive O\nresults O\n. O\n\nIf O\nthat O\nis O\ntrue O\n, O\nthen O\nany O\nnew O\nTreasury B-ORG\nchief O\nwould O\nneed O\nto O\nbe O\nas O\neffective O\nas O\nRubin B-PER\nin O\nconvincing O\nmarkets O\nthat O\nthe O\nWhite B-LOC\nHouse I-LOC\ndoes O\nindeed O\nwant O\na O\nstrong O\ncurrency O\n. O\n\n\" O\nIf O\nhe O\nleft O\n, O\nthe O\nfirst O\nquestion O\npeople O\nwould O\nask O\nthe O\nnext O\nguy O\nis O\n, O\n' O\nWhat O\n's O\nyour O\nview O\non O\nthe O\ndollar O\n? O\n' O\n\n\" O\nsaid O\nMichael B-PER\nPerelstein I-PER\n, O\nportfolio O\nmanager O\nof O\nMainStay B-ORG\nInternational I-ORG\nFunds I-ORG\n. O\n\n\" O\nAnd O\nall O\nI O\ncan O\nsay O\nas O\na O\npiece O\nof O\nadvice O\nis O\nthat O\nthey O\n'd O\nbetter O\nsay O\nexactly O\nthe O\nsame O\nthing O\n( O\nas O\nRubin B-PER\n) O\n, O\nif O\nnot O\nstronger O\n, O\n\" O\nPerelstein B-PER\nsaid O\n. O\n\" O\n\nOtherwise O\n, O\nyou O\nget O\nselling O\nout O\nof O\nTokyo B-LOC\nand O\nFrankfurt B-LOC\nagain O\n. O\n\" O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nAUSTRIA B-LOC\nBEAT O\nSCOTLAND B-LOC\n4-0 O\nIN O\nEUROPEAN B-MISC\nUNDER-21 O\nMATCH O\n. O\n\nAMSTETTEN B-LOC\n, O\nAustria B-LOC\n1996-08-30 O\n\nAustria B-LOC\nbeat O\nScotland B-LOC\n4-0 O\n( O\nhalftime O\n3-0 O\n) O\nin O\na O\nEuropean B-MISC\nunder-21 O\nchampionship O\nmatch O\non O\nFriday O\n. O\n\nScorers O\n: O\nEwald B-PER\nBrenner I-PER\n( O\n5th O\nminute O\n) O\n, O\nMario B-PER\nStieglmair I-PER\n( O\n42nd O\n) O\n, O\nRonald B-PER\nBrunmayr I-PER\n( O\n43rd O\nand O\n56th O\n) O\n. O\n\nAttendance O\n: O\n800 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nWALES B-LOC\nBEAT O\nSAN B-LOC\nMARINO I-LOC\n4-0 O\nIN O\nUNDER-21 O\nMATCH O\n. O\n\nBARRY B-LOC\n, O\nWales B-LOC\n1996-08-30 O\n\nWales B-LOC\nbeat O\nSan B-LOC\nMarino I-LOC\n4-0 O\n( O\nhalftime O\n2-0 O\n) O\nin O\na O\nEuropean B-MISC\nunder-21 O\nsoccer O\nmatch O\non O\nFriday O\n. O\n\nScorers O\n: O\n\nWales B-LOC\n- O\nJohn B-PER\nHartson I-PER\n( O\n12th O\n, O\n56th O\nand O\n83rd O\nminutes O\n) O\n, O\nScott B-PER\nYoung I-PER\n( O\n24th O\n) O\n\nAttendance O\n: O\n1,800 O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nBALLANGER B-PER\nKEEPS O\nSPRINT O\nTITLE O\nIN O\nSTYLE O\n. O\n\nMartin B-PER\nAyres I-PER\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-30 O\n\nFelicia B-PER\nBallanger I-PER\nof O\nFrance B-LOC\nconfirmed O\nher O\nstatus O\nas O\nthe O\nworld O\n's O\nnumber O\none O\nwoman O\nsprinter O\nwhen O\nshe O\nretained O\nher O\ntitle O\nat O\nthe O\nworld O\ncycling O\nchampionships O\non O\nFriday O\n. O\n\nBallanger B-PER\nbeat O\nGermany B-LOC\n's O\nAnnett B-PER\nNeumann I-PER\n2-0 O\nin O\nthe O\nbest-of-three O\nmatches O\nfinal O\nto O\nadd O\nthe O\nworld O\ntitle O\nto O\nthe O\nOlympic B-MISC\ngold O\nmedal O\nshe O\nwon O\nin O\nJuly O\n. O\n\nFrance B-LOC\nalso O\ntook O\nthird O\nplace O\nin O\nthe O\nsprint O\n, O\nMagali B-PER\nFaure I-PER\ndefeating O\nex-world O\nchampion O\nTanya B-PER\nDubnicoff I-PER\nof O\nCanada B-LOC\n2-0 O\n. O\n\nBallanger B-PER\n, O\n25 O\n, O\nwill O\nbe O\naiming O\nto O\ncomplete O\na O\ntrack O\ndouble O\nwhen O\nshe O\ndefends O\nher O\n500 O\nmetres O\ntime O\ntrial O\ntitle O\non O\nSaturday O\n. O\n\nThe O\nother O\nfinal O\nof O\nthe O\nnight O\n, O\nthe O\nwomen O\n's O\n24-kms O\npoints O\nrace O\n, O\nalso O\nended O\nin O\nsuccess O\nfor O\nthe O\nreigning O\nchampion O\n. O\n\nRussia B-LOC\n's O\nSvetlana B-PER\nSamokhalova I-PER\nfought O\noff O\na O\nspirited O\nchallenge O\nfrom O\nAmerican B-MISC\nJane B-PER\nQuigley I-PER\nto O\ntake O\nthe O\ntitle O\nfor O\na O\nsecond O\nyear O\n. O\n\nRussia B-LOC\n, O\nthe O\nonly O\nnation O\nto O\nhave O\ntwo O\nriders O\nin O\nthe O\nfield O\n, O\nmade O\nfull O\nuse O\nof O\ntheir O\nnumerical O\nsuperiority O\n. O\n\nGoulnara B-PER\nFatkoullina I-PER\nhelped O\nSamokhalova B-PER\nto O\nbuild O\nan O\nunbeatable O\npoints O\nlead O\nbefore O\nsnatching O\nthe O\nbronze O\nmedal O\n. O\n\nQuigley B-PER\n, O\na O\nformer O\nmedallist O\nin O\nthe O\npoints O\nevent O\n, O\nled O\nthe O\nrace O\nat O\nhalf O\ndistance O\n. O\n\" O\n\nI O\nwent O\nso O\nclose O\nthis O\ntime O\n, O\nbut O\nhaving O\ntwo O\nriders O\ncertainly O\ngave O\nthe O\nRussians B-MISC\nan O\nadvantage O\n, O\n\" O\nshe O\nsaid O\n. O\n\nThe O\nfirst O\nsix O\nriders O\nlapped O\nthe O\nfield O\n, O\nwhich O\nleft O\nformer O\nworld O\nchampion O\nIngrid B-PER\nHaringa I-PER\nof O\nthe O\nNetherlands B-LOC\ndown O\nin O\nseventh O\nplace O\ndespite O\nhaving O\nthe O\nsecond O\nhighest O\npoints O\nscore O\n. O\n\nOlympic B-MISC\nchampion O\nNathalie B-PER\nLancien I-PER\nof O\nFrance B-LOC\nalso O\nmissed O\nthe O\nwinning O\nattack O\nand O\nfinished O\na O\ndisappointing O\n10th O\n. O\n\n-DOCSTART- O\n\nCYCLING O\n- O\nWORLD O\nTRACK O\nCHAMPIONSHIP O\nRESULTS O\n. O\n\nMANCHESTER B-LOC\n, O\nEngland B-LOC\n1996-08-30 O\n\nResults O\nat O\nthe O\nworld O\ntrack O\ncycling O\nchampionships O\non O\nFriday O\n: O\n\nWomen O\n's O\nsprint O\nsemifinals O\n( O\nbest O\nof O\nthree O\n) O\n: O\n\nAnnett B-PER\nNeumann I-PER\n( O\nGermany B-LOC\n) O\nbeat O\nMagali B-PER\nFaure I-PER\n( O\nFrance B-LOC\n) O\n2-0 O\n( O\n12.341 O\nand O\n12.348 O\nseconds O\nfor O\nthe O\nlast O\n200 O\nmetres O\n) O\n\nFelicia B-PER\nBallanger I-PER\n( O\nFrance B-LOC\n) O\nbeat O\nTanya B-PER\nDubnicoff I-PER\n( O\nCanada B-LOC\n) O\n2-0 O\n, O\n( O\n12.130 O\n/ O\n12.124 O\n) O\n\nRide O\nfor O\nthird O\nplace O\n: O\n\nFaure B-PER\nbeat O\nDubnicoff B-PER\n2-0 O\n( O\n12.112 O\n/ O\n12.246 O\n) O\n\nFinal O\n: O\n\nBallanger B-PER\nbeat O\nNeumann B-PER\n2-0 O\n( O\n11.959 O\n/ O\n12.225 O\n) O\n\nWomen O\n's O\nworld O\npoints O\nrace O\nchampionship O\n( O\n24-km O\n) O\n: O\n\n1. O\nSvetlana B-PER\nSamokhalova I-PER\n( O\nRussia B-LOC\n) O\n28 O\npoints O\n( O\nin O\n32 O\n\nminutes O\n31.081 O\nseconds O\n) O\n\n2. O\nJane B-PER\nQuigley I-PER\n( O\nU.S. B-LOC\n) O\n18 O\npoints O\n\n3. O\nGoulnara B-PER\nFatkoullina I-PER\n( O\nRussia B-LOC\n) O\n16 O\n\n4. O\nTatiana B-PER\nStiajkina I-PER\n( O\nUkraine B-LOC\n) O\n11 O\n\n5. O\nJudith B-PER\nArndt I-PER\n( O\nGermany B-LOC\n) O\n11 O\n\n6. O\nTea B-PER\nVikstedt-Nyman I-PER\n( O\nFinland B-LOC\n) O\n5 O\n\nOne O\nlap O\nbehind O\n: O\n\n7. O\nIngrid B-PER\nHaringa I-PER\n( O\nNetherlands B-LOC\n) O\n20 O\n\n8. O\nSally B-PER\nBoyden I-PER\n( O\nBritain B-LOC\n) O\n9 O\n\n9. O\nAgnieszka B-PER\nGodras I-PER\n( O\nPoland B-LOC\n) O\n8 O\n\n10. O\nNathalie B-PER\nLancien I-PER\n( O\nFrance B-LOC\n) O\n8 O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nFRENCH B-MISC\nDEFENDER O\nKOMBOUARE B-PER\nJOINS O\nABERDEEN B-ORG\n. O\n\nABDERDEEN B-LOC\n, O\nScotland B-LOC\n1996-08-30 O\n\nFrench B-MISC\ncentral O\ndefender O\nAntoine B-PER\nKombouare I-PER\nhas O\ncompleted O\na O\n300,000 O\npounds O\nsterling O\n( O\n$ O\n467,000 O\n) O\nmove O\nto O\nAberdeen B-ORG\nfrom O\nSwiss B-MISC\nclub O\nSion B-ORG\n, O\nthe O\nScottish B-MISC\npremier O\ndivision O\nclub O\nsaid O\non O\nFriday O\n. O\n\nKombouare B-PER\nhas O\nsigned O\na O\ntwo-year O\ncontract O\nand O\nwill O\nmake O\nhis O\ndebut O\nagainst O\nMorton B-PER\nin O\nthe O\nScottish B-MISC\nLeague I-MISC\nCup I-MISC\non O\nTuesday O\n. O\n\nBut O\nhe O\nwill O\nbe O\nineligible O\nfor O\nthe O\nrest O\nof O\nAberdeen B-ORG\n's O\nUEFA B-MISC\nCup I-MISC\ncampaign O\nas O\nhe O\nhas O\nalready O\nplayed O\nfor O\nSion B-ORG\nin O\nthis O\nseason O\n's O\nCup B-MISC\nWinners I-MISC\n' I-MISC\nCup I-MISC\n. O\n\nAberdeen B-ORG\nmanager O\nRoy B-PER\nAitken I-PER\nsaid O\n: O\n\" O\nIt O\n's O\nunfortunate O\nfor O\nus O\nthat O\nAntoine B-PER\ncannot O\nplay O\nin O\nEurope B-LOC\nbut O\nhe O\nwill O\nhelp O\nus O\nachieve O\nthings O\nin O\ndomestic O\ncompetition O\n. O\n\n\" O\nI O\nhave O\nbeen O\nwatching O\nhim O\nfor O\nseveral O\nweeks O\nnow O\nand O\nhave O\nno O\ndoubts O\nhe O\nbrings O\nreal O\nquality O\nto O\nthe O\nside O\n. O\n\nHe O\nhas O\na O\ngreat O\ndeal O\nof O\nexperience O\nand O\nI O\n'm O\nsure O\nhe O\nwill O\nquickly O\nestablish O\nhimself O\nin O\nboth O\nthe O\nteam O\nand O\nthe O\naffection O\nof O\nour O\nfans O\n. O\n\" O\n\nThe O\n32-year-old O\ndefender O\nplayed O\nseven O\nseasons O\nwith O\nNantes B-ORG\nand O\nwas O\nwith O\nParis B-ORG\nSt I-ORG\nGermain I-ORG\nfor O\nfive O\nseasons O\n. O\n\nHe O\nsaid O\nformer O\nPSG B-ORG\nteam O\nmate O\nDavid B-PER\nGinola I-PER\n, O\nwho O\nnow O\nplays O\nfor O\nEnglish B-MISC\npremier O\nleague O\nNewcastle B-ORG\n, O\nwas O\ninfluential O\nin O\nhis O\nmove O\nto O\nScotland B-LOC\n. O\n\n\" O\nI O\n'm O\na O\nvery O\ngood O\nfriend O\nof O\nDavid B-PER\nand O\nspoke O\nto O\nhim O\nrecently O\nabout O\ncoming O\nto O\nAberdeen B-ORG\nand O\nhe O\nwas O\nvery O\npositive O\nabout O\nit O\n, O\n\" O\nKombouare B-PER\nsaid O\n. O\n\n\" O\nHe O\nsaid O\nI O\nwould O\nreally O\nenjoy O\nlife O\nthere O\nand O\nthat O\nI O\nwould O\nsettle O\nin O\nin O\nterms O\nof O\nfootball O\nas O\nwell O\n. O\n\nThat O\n, O\nand O\nthe O\nfact O\nhe O\nis O\nonly O\na O\nfew O\nhours O\ndrive O\naway O\n, O\ninfluenced O\nmy O\ndecision O\nto O\ncome O\nto O\nAberdeen B-ORG\n. O\n\" O\n\n-DOCSTART- O\n\nMOTORCYCLING O\n- O\nSAN B-LOC\nMARINO I-LOC\nGRAND B-MISC\nPRIX I-MISC\nPRACTICE O\nTIMES O\n. O\n\nIMOLA B-LOC\n, O\nItaly B-LOC\n1996-08-30 O\n\nPractice O\ntimes O\nset O\non O\nFriday O\n\nfor O\nSunday O\n's O\nSan B-LOC\nMarino I-LOC\n500cc O\nmotorcycling O\nGrand B-MISC\nPrix I-MISC\n: O\n\n1. O\nMichael B-PER\nDoohan I-PER\n( O\nAustralia B-LOC\n) O\nHonda B-ORG\none O\nminute O\n50.250 O\n\n2. O\nJean-Michel B-PER\nBayle I-PER\n( O\nFrance B-LOC\n) O\nYamaha B-ORG\n1:50.727 O\n\n3. O\nNorifumi B-PER\nAbe I-PER\n( O\nJapan B-LOC\n) O\nYamaha B-ORG\n1:50.858 O\n\n4. O\nLuca B-PER\nCadalora I-PER\n( O\nItaly B-LOC\n) O\nHonda B-ORG\n1:51.006 O\n\n5. O\nAlex B-PER\nCriville I-PER\n( O\nSpain B-LOC\n) O\nHonda B-ORG\n1:51.075 O\n\n6. O\nScott B-PER\nRussell I-PER\n( O\nUnited B-LOC\nStates I-LOC\n) O\nSuzuki B-ORG\n1:51.287 O\n\n7. O\nTadayuki B-PER\nOkada I-PER\n( O\nJapan B-LOC\n) O\nHonda B-ORG\n1:51.528 O\n\n8. O\nCarlos B-PER\nCheca I-PER\n( O\nSpain B-LOC\n) O\nHonda B-ORG\n1:51.588 O\n\n9. O\nAlexandre B-PER\nBarros I-PER\n( O\nBrazil B-LOC\n) O\nHonda B-ORG\n1:51.784 O\n\n10. O\nShinichi B-PER\nItoh I-PER\n( O\nJapan B-LOC\n) O\nHonda B-ORG\n1:51.857 O\n\n-DOCSTART- O\n\nGOLF O\n- O\nBRITISH B-MISC\nMASTERS I-MISC\nTHIRD O\nROUND O\nSCORES O\n. O\n\nNORTHAMPTON B-LOC\n, O\nEngland B-LOC\n1996-08-30 O\n\nLeading O\nscores O\nafter O\n\nthe O\nthird O\nround O\nof O\nthe O\nBritish B-MISC\nMasters I-MISC\non O\nFriday O\n: O\n\n211 O\nRobert B-PER\nAllenby I-PER\n( O\nAustralia B-LOC\n) O\n69 O\n71 O\n71 O\n\n212 O\nPedro B-PER\nLinhart I-PER\n( O\nSpain B-LOC\n) O\n72 O\n73 O\n67 O\n\n216 O\nMiguel B-PER\nAngel I-PER\nMartin I-PER\n( O\nSpain B-LOC\n) O\n75 O\n70 O\n71 O\n, O\nCostantino B-PER\nRocca I-PER\n\n( O\nItaly B-LOC\n) O\n71 O\n73 O\n72 O\n\n217 O\nAntoine B-PER\nLebouc I-PER\n( O\nFrance B-LOC\n) O\n74 O\n73 O\n70 O\n, O\nIan B-PER\nWoosnam I-PER\n70 O\n76 O\n71 O\n, O\n\nFrancisco B-PER\nCea I-PER\n( O\nSpain B-LOC\n) O\n70 O\n71 O\n76 O\n, O\nGavin B-PER\nLevenson I-PER\n( O\nSouth B-LOC\n\nAfrica B-LOC\n) O\n66 O\n75 O\n76 O\n\n218 O\nStephen B-PER\nMcAllister I-PER\n73 O\n76 O\n69 O\n, O\nJoakim B-PER\nHaeggman I-PER\n( O\nSwe B-LOC\n) O\n71 O\n77 O\n\n70 O\n, O\nJose B-PER\nCoceres I-PER\n( O\nArgentina B-LOC\n) O\n69 O\n78 O\n71 O\n, O\nPaul B-PER\nEales I-PER\n75 O\n71 O\n72 O\n, O\n\nKlas B-PER\nEriksson I-PER\n( O\nSweden B-LOC\n) O\n71 O\n75 O\n72 O\n, O\nMike B-PER\nClayton I-PER\n( O\nAustralia B-LOC\n) O\n\n69 O\n76 O\n73 O\n, O\nMark B-PER\nRoe I-PER\n69 O\n71 O\n78 O\n\n219 O\nEamonn B-PER\nDarcy I-PER\n( O\nIreland B-LOC\n) O\n74 O\n76 O\n69 O\n, O\nBob B-PER\nMay I-PER\n( O\nU.S. B-LOC\n) O\n74 O\n75 O\n70 O\n, O\n\nPaul B-PER\nLawrie I-PER\n72 O\n75 O\n72 O\n, O\nMiguel B-PER\nAngel I-PER\nJimenez I-PER\n( O\nSpain B-LOC\n) O\n74 O\n72 O\n\n73 O\n, O\nPeter B-PER\nMitchell I-PER\n74 O\n71 O\n75 O\n, O\nPhilip B-PER\nWalton I-PER\n( O\nIreland B-LOC\n) O\n71 O\n74 O\n\n74 O\n, O\nPeter B-PER\nO'Malley I-PER\n( O\nAustralia B-LOC\n) O\n71 O\n73 O\n75 O\n\n220 O\nBarry B-PER\nLane I-PER\n73 O\n77 O\n70 O\n, O\nWayne B-PER\nRiley I-PER\n( O\nAustralia B-LOC\n) O\n71 O\n78 O\n71 O\n, O\n\nMartin B-PER\nGates I-PER\n71 O\n77 O\n72 O\n, O\nBradley B-PER\nHughes I-PER\n( O\nAustralia B-LOC\n) O\n73 O\n75 O\n72 O\n, O\n\nPeter B-PER\nHedblom I-PER\n( O\nSweden B-LOC\n) O\n70 O\n75 O\n75 O\n, O\nRetief B-PER\nGoosen I-PER\n( O\nSouth B-LOC\n\nAfrica B-LOC\n) O\n71 O\n74 O\n75 O\n, O\nDavid B-PER\nGilford I-PER\n69 O\n74 O\n77 O\n. O\n\n-DOCSTART- O\n\nSOCCER O\n- O\nENGLISH B-MISC\nSOCCER O\nRESULTS O\n. O\n\nLONDON B-LOC\n1996-08-30 O\n\nResults O\nof O\nEnglish B-MISC\nleague O\nmatches O\n\non O\nFriday O\n: O\n\nDivision O\ntwo O\n\nPlymouth B-ORG\n2 O\nPreston B-ORG\n1 O\n\nDivision O\nthree O\n\nSwansea B-ORG\n1 O\nLincoln B-ORG\n2 O\n\n"
  },
  {
    "path": "dataset/CONLL/train_20.txt",
    "content": "EU\tB-ORG\nrejects\tO\nGerman\tB-MISC\ncall\tO\nto\tO\nboycott\tO\nBritish\tB-MISC\nlamb\tO\n.\tO\n\nThe\tO\nEuropean\tB-ORG\nCommission\tI-ORG\nsaid\tO\non\tO\nThursday\tO\nit\tO\ndisagreed\tO\nwith\tO\nGerman\tB-MISC\nadvice\tO\nto\tO\nconsumers\tO\nto\tO\nshun\tO\nBritish\tB-MISC\nlamb\tO\nuntil\tO\nscientists\tO\ndetermine\tO\nwhether\tO\nmad\tO\ncow\tO\ndisease\tO\ncan\tO\nbe\tO\ntransmitted\tO\nto\tO\nsheep\tO\n.\tO\n\nGermany\tB-LOC\n's\tO\nrepresentative\tO\nto\tO\nthe\tO\nEuropean\tB-ORG\nUnion\tI-ORG\n's\tO\nveterinary\tO\ncommittee\tO\nWerner\tB-PER\nZwingmann\tI-PER\nsaid\tO\non\tO\nWednesday\tO\nconsumers\tO\nshould\tO\nbuy\tO\nsheepmeat\tO\nfrom\tO\ncountries\tO\nother\tO\nthan\tO\nBritain\tB-LOC\nuntil\tO\nthe\tO\nscientific\tO\nadvice\tO\nwas\tO\nclearer\tO\n.\tO\n\n\"\tO\nWe\tO\ndo\tO\nn't\tO\nsupport\tO\nany\tO\nsuch\tO\nrecommendation\tO\nbecause\tO\nwe\tO\ndo\tO\nn't\tO\nsee\tO\nany\tO\ngrounds\tO\nfor\tO\nit\tO\n,\tO\n\"\tO\nthe\tO\nCommission\tB-ORG\n's\tO\nchief\tO\nspokesman\tO\nNikolaus\tB-PER\nvan\tI-PER\nder\tI-PER\nPas\tI-PER\ntold\tO\na\tO\nnews\tO\nbriefing\tO\n.\tO\n\nHe\tO\nsaid\tO\nfurther\tO\nscientific\tO\nstudy\tO\nwas\tO\nrequired\tO\nand\tO\nif\tO\nit\tO\nwas\tO\nfound\tO\nthat\tO\naction\tO\nwas\tO\nneeded\tO\nit\tO\nshould\tO\nbe\tO\ntaken\tO\nby\tO\nthe\tO\nEuropean\tB-ORG\nUnion\tI-ORG\n.\tO\n\nHe\tO\nsaid\tO\na\tO\nproposal\tO\nlast\tO\nmonth\tO\nby\tO\nEU\tB-ORG\nFarm\tO\nCommissioner\tO\nFranz\tB-PER\nFischler\tI-PER\nto\tO\nban\tO\nsheep\tO\nbrains\tO\n,\tO\nspleens\tO\nand\tO\nspinal\tO\ncords\tO\nfrom\tO\nthe\tO\nhuman\tO\nand\tO\nanimal\tO\nfood\tO\nchains\tO\nwas\tO\na\tO\nhighly\tO\nspecific\tO\nand\tO\nprecautionary\tO\nmove\tO\nto\tO\nprotect\tO\nhuman\tO\nhealth\tO\n.\tO\n\nFischler\tB-PER\nproposed\tO\nEU-wide\tB-MISC\nmeasures\tO\nafter\tO\nreports\tO\nfrom\tO\nBritain\tB-LOC\nand\tO\nFrance\tB-LOC\nthat\tO\nunder\tO\nlaboratory\tO\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tB-MISC\nSpongiform\tI-MISC\nEncephalopathy\tI-MISC\n(\tO\nBSE\tB-MISC\n)\tO\n--\tO\nmad\tO\ncow\tO\ndisease\tO\n.\tO\n\nBut\tO\nFischler\tB-PER\nagreed\tO\nto\tO\nreview\tO\nhis\tO\nproposal\tO\nafter\tO\nthe\tO\nEU\tB-ORG\n's\tO\nstanding\tO\nveterinary\tO\ncommittee\tO\n,\tO\nmational\tO\nanimal\tO\nhealth\tO\nofficials\tO\n,\tO\nquestioned\tO\nif\tO\nsuch\tO\naction\tO\nwas\tO\njustified\tO\nas\tO\nthere\tO\nwas\tO\nonly\tO\na\tO\nslight\tO\nrisk\tO\nto\tO\nhuman\tO\nhealth\tO\n.\tO\n\nSpanish\tB-MISC\nFarm\tO\nMinister\tO\nLoyola\tB-PER\nde\tI-PER\nPalacio\tI-PER\nhad\tO\nearlier\tO\naccused\tO\nFischler\tB-PER\nat\tO\nan\tO\nEU\tB-ORG\nfarm\tO\nministers\tO\n'\tO\nmeeting\tO\nof\tO\ncausing\tO\nunjustified\tO\nalarm\tO\nthrough\tO\n\"\tO\ndangerous\tO\ngeneralisation\tO\n.\tO\n\"\tO\n\nOnly\tO\nFrance\tB-LOC\nand\tO\nBritain\tB-LOC\nbacked\tO\nFischler\tB-PER\n's\tO\nproposal\tO\n.\tO\n\nThe\tO\nEU\tB-ORG\n's\tO\nscientific\tO\nveterinary\tO\nand\tO\nmultidisciplinary\tO\ncommittees\tO\nare\tO\ndue\tO\nto\tO\nre-examine\tO\nthe\tO\nissue\tO\nearly\tO\nnext\tO\nmonth\tO\nand\tO\nmake\tO\nrecommendations\tO\nto\tO\nthe\tO\nsenior\tO\nveterinary\tO\nofficials\tO\n.\tO\n\nSheep\tO\nhave\tO\nlong\tO\nbeen\tO\nknown\tO\nto\tO\ncontract\tO\nscrapie\tO\n,\tO\na\tO\nbrain-wasting\tO\ndisease\tO\nsimilar\tO\nto\tO\nBSE\tB-MISC\nwhich\tO\nis\tO\nbelieved\tO\nto\tO\nhave\tO\nbeen\tO\ntransferred\tO\nto\tO\ncattle\tO\nthrough\tO\nfeed\tO\ncontaining\tO\nanimal\tO\nwaste\tO\n.\tO\n\nBritish\tB-MISC\nfarmers\tO\ndenied\tO\non\tO\nThursday\tO\nthere\tO\nwas\tO\nany\tO\ndanger\tO\nto\tO\nhuman\tO\nhealth\tO\nfrom\tO\ntheir\tO\nsheep\tO\n,\tO\nbut\tO\nexpressed\tO\nconcern\tO\nthat\tO\nGerman\tB-MISC\ngovernment\tO\nadvice\tO\nto\tO\nconsumers\tO\nto\tO\navoid\tO\nBritish\tB-MISC\nlamb\tO\nmight\tO\ninfluence\tO\nconsumers\tO\nacross\tO\nEurope\tB-LOC\n.\tO\n\n\"\tO\nWhat\tO\nwe\tO\nhave\tO\nto\tO\nbe\tO\nextremely\tO\ncareful\tO\nof\tO\nis\tO\nhow\tO\nother\tO\ncountries\tO\nare\tO\ngoing\tO\nto\tO\ntake\tO\nGermany\tB-LOC\n's\tO\nlead\tO\n,\tO\n\"\tO\nWelsh\tB-ORG\nNational\tI-ORG\nFarmers\tI-ORG\n'\tI-ORG\nUnion\tI-ORG\n(\tO\nNFU\tB-ORG\n)\tO\nchairman\tO\nJohn\tB-PER\nLloyd\tI-PER\nJones\tI-PER\nsaid\tO\non\tO\nBBC\tB-ORG\nradio\tI-ORG\n.\tO\n\nBonn\tB-LOC\nhas\tO\nled\tO\nefforts\tO\nto\tO\nprotect\tO\npublic\tO\nhealth\tO\nafter\tO\nconsumer\tO\nconfidence\tO\ncollapsed\tO\nin\tO\nMarch\tO\nafter\tO\na\tO\nBritish\tB-MISC\nreport\tO\nsuggested\tO\nhumans\tO\ncould\tO\ncontract\tO\nan\tO\nillness\tO\nsimilar\tO\nto\tO\nmad\tO\ncow\tO\ndisease\tO\nby\tO\neating\tO\ncontaminated\tO\nbeef\tO\n.\tO\n\nGermany\tB-LOC\nimported\tO\n47,600\tO\nsheep\tO\nfrom\tO\nBritain\tB-LOC\nlast\tO\nyear\tO\n,\tO\nnearly\tO\nhalf\tO\nof\tO\ntotal\tO\nimports\tO\n.\tO\n\nIt\tO\nbrought\tO\nin\tO\n4,275\tO\ntonnes\tO\nof\tO\nBritish\tB-MISC\nmutton\tO\n,\tO\nsome\tO\n10\tO\npercent\tO\nof\tO\noverall\tO\nimports\tO\n.\tO\n\nRare\tO\nHendrix\tB-PER\nsong\tO\ndraft\tO\nsells\tO\nfor\tO\nalmost\tO\n$\tO\n17,000\tO\n.\tO\n\nA\tO\nrare\tO\nearly\tO\nhandwritten\tO\ndraft\tO\nof\tO\na\tO\nsong\tO\nby\tO\nU.S.\tB-LOC\nguitar\tO\nlegend\tO\nJimi\tB-PER\nHendrix\tI-PER\nwas\tO\nsold\tO\nfor\tO\nalmost\tO\n$\tO\n17,000\tO\non\tO\nThursday\tO\nat\tO\nan\tO\nauction\tO\nof\tO\nsome\tO\nof\tO\nthe\tO\nlate\tO\nmusician\tO\n's\tO\nfavourite\tO\npossessions\tO\n.\tO\n\nA\tO\nFlorida\tB-LOC\nrestaurant\tO\npaid\tO\n10,925\tO\npounds\tO\n(\tO\n$\tO\n16,935\tO\n)\tO\nfor\tO\nthe\tO\ndraft\tO\nof\tO\n\"\tO\nAi\tB-MISC\nn't\tI-MISC\nno\tI-MISC\ntelling\tI-MISC\n\"\tO\n,\tO\nwhich\tO\nHendrix\tB-PER\npenned\tO\non\tO\na\tO\npiece\tO\nof\tO\nLondon\tB-LOC\nhotel\tO\nstationery\tO\nin\tO\nlate\tO\n1966\tO\n.\tO\n\nAt\tO\nthe\tO\nend\tO\nof\tO\na\tO\nJanuary\tO\n1967\tO\nconcert\tO\nin\tO\nthe\tO\nEnglish\tB-MISC\ncity\tO\nof\tO\nNottingham\tB-LOC\nhe\tO\nthrew\tO\nthe\tO\nsheet\tO\nof\tO\npaper\tO\ninto\tO\nthe\tO\naudience\tO\n,\tO\nwhere\tO\nit\tO\nwas\tO\nretrieved\tO\nby\tO\na\tO\nfan\tO\n.\tO\n\nBuyers\tO\nalso\tO\nsnapped\tO\nup\tO\n16\tO\nother\tO\nitems\tO\nthat\tO\nwere\tO\nput\tO\nup\tO\nfor\tO\nauction\tO\nby\tO\nHendrix\tB-PER\n's\tO\nformer\tO\ngirlfriend\tO\nKathy\tB-PER\nEtchingham\tI-PER\n,\tO\nwho\tO\nlived\tO\nwith\tO\nhim\tO\nfrom\tO\n1966\tO\nto\tO\n1969\tO\n.\tO\n\nThey\tO\nincluded\tO\na\tO\nblack\tO\nlacquer\tO\nand\tO\nmother\tO\nof\tO\npearl\tO\ninlaid\tO\nbox\tO\nused\tO\nby\tO\nHendrix\tB-PER\nto\tO\nstore\tO\nhis\tO\ndrugs\tO\n,\tO\nwhich\tO\nan\tO\nanonymous\tO\nAustralian\tB-MISC\npurchaser\tO\nbought\tO\nfor\tO\n5,060\tO\npounds\tO\n(\tO\n$\tO\n7,845\tO\n)\tO\n.\tO\n\nChina\tB-LOC\nsays\tO\nTaiwan\tB-LOC\nspoils\tO\natmosphere\tO\nfor\tO\ntalks\tO\n.\tO\n\nChina\tB-LOC\non\tO\nThursday\tO\naccused\tO\nTaipei\tB-LOC\nof\tO\nspoiling\tO\nthe\tO\natmosphere\tO\nfor\tO\na\tO\nresumption\tO\nof\tO\ntalks\tO\nacross\tO\nthe\tO\nTaiwan\tB-LOC\nStrait\tI-LOC\nwith\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tB-LOC\nby\tO\nTaiwanese\tB-MISC\nVice\tO\nPresident\tO\nLien\tB-PER\nChan\tI-PER\nthis\tO\nweek\tO\nthat\tO\ninfuriated\tO\nBeijing\tB-LOC\n.\tO\n\nSpeaking\tO\nonly\tO\nhours\tO\nafter\tO\nChinese\tB-MISC\nstate\tO\nmedia\tO\nsaid\tO\nthe\tO\ntime\tO\nwas\tO\nright\tO\nto\tO\nengage\tO\nin\tO\npolitical\tO\ntalks\tO\nwith\tO\nTaiwan\tB-LOC\n,\tO\nForeign\tB-ORG\nMinistry\tI-ORG\nspokesman\tO\nShen\tB-PER\nGuofang\tI-PER\ntold\tO\nReuters\tB-ORG\n:\tO\n\"\tO\nThe\tO\nnecessary\tO\natmosphere\tO\nfor\tO\nthe\tO\nopening\tO\nof\tO\nthe\tO\ntalks\tO\nhas\tO\nbeen\tO\ndisrupted\tO\nby\tO\nthe\tO\nTaiwan\tB-LOC\nauthorities\tO\n.\tO\n\"\tO\n\nState\tO\nmedia\tO\nquoted\tO\nChina\tB-LOC\n's\tO\ntop\tO\nnegotiator\tO\nwith\tO\nTaipei\tB-LOC\n,\tO\nTang\tB-PER\nShubei\tI-PER\n,\tO\nas\tO\ntelling\tO\na\tO\nvisiting\tO\ngroup\tO\nfrom\tO\nTaiwan\tB-LOC\non\tO\nWednesday\tO\nthat\tO\nit\tO\nwas\tO\ntime\tO\nfor\tO\nthe\tO\nrivals\tO\nto\tO\nhold\tO\npolitical\tO\ntalks\tO\n.\tO\n\nthat\tO\nis\tO\nto\tO\nend\tO\nthe\tO\nstate\tO\nof\tO\nhostility\tO\n,\tO\n\"\tO\nThursday\tO\n's\tO\noverseas\tO\nedition\tO\nof\tO\nthe\tO\nPeople\tB-ORG\n's\tI-ORG\nDaily\tI-ORG\nquoted\tO\nTang\tB-PER\nas\tO\nsaying\tO\n.\tO\n\nThe\tO\nforeign\tO\nministry\tO\n's\tO\nShen\tB-ORG\ntold\tO\nReuters\tB-ORG\nTelevision\tI-ORG\nin\tO\nan\tO\ninterview\tO\nhe\tO\nhad\tO\nread\tO\nreports\tO\nof\tO\nTang\tB-PER\n's\tO\ncomments\tO\nbut\tO\ngave\tO\nno\tO\ndetails\tO\nof\tO\nwhy\tO\nthe\tO\nnegotiator\tO\nhad\tO\nconsidered\tO\nthe\tO\ntime\tO\nright\tO\nfor\tO\ntalks\tO\nwith\tO\nTaiwan\tB-LOC\n,\tO\nwhich\tO\nBeijing\tB-LOC\nconsiders\tO\na\tO\nrenegade\tO\nprovince\tO\n.\tO\n\nChina\tB-LOC\n,\tO\nwhich\tO\nhas\tO\nlong\tO\nopposed\tO\nall\tO\nTaipei\tB-LOC\nefforts\tO\nto\tO\ngain\tO\ngreater\tO\ninternational\tO\nrecognition\tO\n,\tO\nwas\tO\ninfuriated\tO\nby\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tB-LOC\nthis\tO\nweek\tO\nby\tO\nTaiwanese\tB-MISC\nVice\tO\nPresident\tO\nLien\tB-PER\n.\tO\n\nChina\tB-LOC\nsays\tO\ntime\tO\nright\tO\nfor\tO\nTaiwan\tB-LOC\ntalks\tO\n.\tO\n\nChina\tB-LOC\nhas\tO\nsaid\tO\nit\tO\nwas\tO\ntime\tO\nfor\tO\npolitical\tO\ntalks\tO\nwith\tO\nTaiwan\tB-LOC\nand\tO\nthat\tO\nthe\tO\nrival\tO\nisland\tO\nshould\tO\ntake\tO\npractical\tO\nsteps\tO\ntowards\tO\nthat\tO\ngoal\tO\n.\tO\n\nConsultations\tO\nshould\tO\nbe\tO\nheld\tO\nto\tO\nset\tO\nthe\tO\ntime\tO\nand\tO\nformat\tO\nof\tO\nthe\tO\ntalks\tO\n,\tO\nthe\tO\nofficial\tO\nXinhua\tB-ORG\nnews\tO\nagency\tO\nquoted\tO\nTang\tB-PER\nShubei\tI-PER\n,\tO\nexecutive\tO\nvice\tO\nchairman\tO\nof\tO\nthe\tO\nAssociation\tB-ORG\nfor\tI-ORG\nRelations\tI-ORG\nAcross\tI-ORG\nthe\tI-ORG\nTaiwan\tI-ORG\nStraits\tI-ORG\n,\tO\nas\tO\nsaying\tO\nlate\tO\non\tO\nWednesday\tO\n.\tO\n\nGerman\tB-MISC\nfirst-time\tO\nregistrations\tO\nof\tO\nmotor\tO\nvehicles\tO\njumped\tO\n14.2\tO\npercent\tO\nin\tO\nJuly\tO\nthis\tO\nyear\tO\nfrom\tO\nthe\tO\nyear-earlier\tO\nperiod\tO\n,\tO\nthe\tO\nFederal\tB-ORG\noffice\tI-ORG\nfor\tI-ORG\nmotor\tI-ORG\nvehicles\tI-ORG\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\ngrowth\tO\nwas\tO\npartly\tO\ndue\tO\nto\tO\nan\tO\nincreased\tO\nnumber\tO\nof\tO\nGermans\tB-MISC\nbuying\tO\nGerman\tB-MISC\ncars\tO\nabroad\tO\n,\tO\nwhile\tO\nmanufacturers\tO\nsaid\tO\nthat\tO\ndomestic\tO\ndemand\tO\nwas\tO\nweak\tO\n,\tO\nthe\tO\nfederal\tO\noffice\tO\nsaid\tO\n.\tO\n\nAlmost\tO\nall\tO\nGerman\tB-MISC\ncar\tO\nmanufacturers\tO\nposted\tO\ngains\tO\nin\tO\nregistration\tO\nnumbers\tO\nin\tO\nthe\tO\nperiod\tO\n.\tO\n\nVolkswagen\tB-ORG\nAG\tI-ORG\nwon\tO\n77,719\tO\nregistrations\tO\n,\tO\nslightly\tO\nmore\tO\nthan\tO\na\tO\nquarter\tO\nof\tO\nthe\tO\ntotal\tO\n.\tO\n\nOpel\tB-ORG\nAG\tI-ORG\ntogether\tO\nwith\tO\nGeneral\tB-ORG\nMotors\tI-ORG\ncame\tO\nin\tO\nsecond\tO\nplace\tO\nwith\tO\n49,269\tO\nregistrations\tO\n,\tO\n16.4\tO\npercent\tO\nof\tO\nthe\tO\noverall\tO\nfigure\tO\n.\tO\n\nThird\tO\nwas\tO\nFord\tB-ORG\nwith\tO\n35,563\tO\nregistrations\tO\n,\tO\nor\tO\n11.7\tO\npercent\tO\n.\tO\n\nOnly\tO\nSeat\tB-ORG\nand\tO\nPorsche\tB-ORG\nhad\tO\nfewer\tO\nregistrations\tO\nin\tO\nJuly\tO\n1996\tO\ncompared\tO\nto\tO\nlast\tO\nyear\tO\n's\tO\nJuly\tO\n.\tO\n\nSeat\tB-ORG\nposted\tO\n3,420\tO\nregistrations\tO\ncompared\tO\nwith\tO\n5522\tO\nregistrations\tO\nin\tO\nJuly\tO\na\tO\nyear\tO\nearlier\tO\n.\tO\n\nGREEK\tB-MISC\nSOCIALISTS\tO\nGIVE\tO\nGREEN\tO\nLIGHT\tO\nTO\tO\nPM\tO\nFOR\tO\nELECTIONS\tO\n.\tO\n\nThe\tO\nGreek\tB-MISC\nsocialist\tO\nparty\tO\n's\tO\nexecutive\tO\nbureau\tO\ngave\tO\nthe\tO\ngreen\tO\nlight\tO\nto\tO\nPrime\tO\nMinister\tO\nCostas\tB-PER\nSimitis\tI-PER\nto\tO\ncall\tO\nsnap\tO\nelections\tO\n,\tO\nits\tO\ngeneral\tO\nsecretary\tO\nCostas\tB-PER\nSkandalidis\tI-PER\ntold\tO\nreporters\tO\n.\tO\n\nPrime\tO\nMinister\tO\nCostas\tB-PER\nSimitis\tI-PER\nis\tO\ngoing\tO\nto\tO\nmake\tO\nan\tO\nofficial\tO\nannouncement\tO\nafter\tO\na\tO\ncabinet\tO\nmeeting\tO\nlater\tO\non\tO\nThursday\tO\n,\tO\nsaid\tO\nSkandalidis\tB-PER\n.\tO\n\n--\tO\nDimitris\tB-PER\nKontogiannis\tI-PER\n,\tO\nAthens\tB-ORG\nNewsroom\tI-ORG\n+301\tO\n3311812-4\tO\n\nBayerVB\tB-ORG\nsets\tO\nC$\tB-MISC\n100\tO\nmillion\tO\nsix-year\tO\nbond\tO\n.\tO\n\nThe\tO\nfollowing\tO\nbond\tO\nwas\tO\nannounced\tO\nby\tO\nlead\tO\nmanager\tO\nToronto\tB-PER\nDominion\tI-PER\n.\tO\n\nBORROWER\tO\nBAYERISCHE\tB-ORG\nVEREINSBANK\tI-ORG\n\nAMT\tO\nC$\tB-MISC\n100\tO\nMLN\tO\nCOUPON\tO\n6.625\tO\nMATURITY\tO\n24.SEP.02\tO\n\nS&P\tB-ORG\n=\tO\nDENOMS\tO\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tO\nLIMITS\tO\nUS\tB-LOC\n/\tO\nUK\tB-LOC\n/\tO\nCA\tB-LOC\n\nGOV\tO\nLAW\tO\nGERMAN\tB-MISC\nHOME\tO\nCTRY\tO\n=\tO\nTAX\tO\nPROVS\tO\nSTANDARD\tO\n\nNOTES\tO\nBAYERISCHE\tB-ORG\nVEREINSBANK\tI-ORG\nIS\tO\nJOINT\tO\nLEAD\tO\nMANAGER\tO\n\nVenantius\tB-ORG\nsets\tO\n$\tO\n300\tO\nmillion\tO\nJanuary\tO\n1999\tO\nFRN\tO\n.\tO\n\nThe\tO\nfollowing\tO\nfloating-rate\tO\nissue\tO\nwas\tO\nannounced\tO\nby\tO\nlead\tO\nmanager\tO\nLehman\tB-ORG\nBrothers\tI-ORG\nInternational\tI-ORG\n.\tO\n\nBORROWER\tO\nVENANTIUS\tB-ORG\nAB\tI-ORG\n(\tO\nSWEDISH\tB-MISC\nNATIONAL\tO\nMORTGAGE\tO\nAGENCY\tO\n)\tO\n\nTYPE\tO\nFRN\tO\nBASE\tO\n3M\tB-ORG\nLIBOR\tO\nPAY\tO\nDATE\tO\nS23.SEP.96\tO\n\nLAST\tO\nS&P\tB-ORG\nAA+\tO\nREOFFER\tO\n=\tO\n\nLISTING\tO\nLONDON\tB-LOC\nDENOMS\tO\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tO\nLIMITS\tO\nUS\tB-LOC\n/\tO\nUK\tB-LOC\n/\tO\nJP\tB-LOC\n/\tO\nFR\tB-LOC\n\nGOV\tO\nLAW\tO\nENGLISH\tB-MISC\nHOME\tO\nCTRY\tO\nSWEDEN\tB-LOC\nTAX\tO\nPROVS\tO\nSTANDARD\tO\n\n--\tO\nLondon\tB-ORG\nNewsroom\tI-ORG\n+44\tO\n171\tO\n542\tO\n8863\tO\n\nPort\tO\nconditions\tO\nupdate\tO\n-\tO\nSyria\tB-LOC\n-\tO\nLloyds\tB-ORG\nShipping\tI-ORG\n.\tO\n\nPort\tO\nconditions\tO\nfrom\tO\nLloyds\tB-ORG\nShipping\tI-ORG\nIntelligence\tI-ORG\nService\tI-ORG\n--\tO\n\nLATTAKIA\tB-LOC\n,\tO\nAug\tO\n10\tO\n-\tO\nwaiting\tO\ntime\tO\nat\tO\nLattakia\tB-LOC\nand\tO\nTartous\tB-LOC\npresently\tO\n24\tO\nhours\tO\n.\tO\n\nIsrael\tB-LOC\nplays\tO\ndown\tO\nfears\tO\nof\tO\nwar\tO\nwith\tO\nSyria\tB-LOC\n.\tO\n\nIsrael\tB-LOC\n's\tO\noutgoing\tO\npeace\tO\nnegotiator\tO\nwith\tO\nSyria\tB-LOC\nsaid\tO\non\tO\nThursday\tO\ncurrent\tO\ntensions\tO\nbetween\tO\nthe\tO\ntwo\tO\ncountries\tO\nappeared\tO\nto\tO\nbe\tO\na\tO\nstorm\tO\nin\tO\na\tO\nteacup\tO\n.\tO\n\nItamar\tB-PER\nRabinovich\tI-PER\n,\tO\nwho\tO\nas\tO\nIsrael\tB-LOC\n's\tO\nambassador\tO\nto\tO\nWashington\tB-LOC\nconducted\tO\nunfruitful\tO\nnegotiations\tO\nwith\tO\nSyria\tB-LOC\n,\tO\ntold\tO\nIsrael\tB-ORG\nRadio\tI-ORG\nit\tO\nlooked\tO\nlike\tO\nDamascus\tO\nwanted\tO\nto\tO\ntalk\tO\nrather\tO\nthan\tO\nfight\tO\n.\tO\n\n\"\tO\nIt\tO\nappears\tO\nto\tO\nme\tO\nthe\tO\nSyrian\tB-MISC\npriority\tO\nis\tO\nstill\tO\nto\tO\nnegotiate\tO\n.\tO\n\nThe\tO\nSyrians\tB-MISC\nare\tO\nconfused\tO\n,\tO\nthey\tO\nare\tO\ndefinitely\tO\ntense\tO\n,\tO\nbut\tO\nthe\tO\ngeneral\tO\nassessment\tO\nhere\tO\nin\tO\nWashington\tB-LOC\nis\tO\nthat\tO\nthis\tO\nis\tO\nessentially\tO\na\tO\nstorm\tO\nin\tO\na\tO\nteacup\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\nRabinovich\tB-PER\nis\tO\nwinding\tO\nup\tO\nhis\tO\nterm\tO\nas\tO\nambassador\tO\n.\tO\n\nHe\tO\nwill\tO\nbe\tO\nreplaced\tO\nby\tO\nEliahu\tB-PER\nBen-Elissar\tI-PER\n,\tO\na\tO\nformer\tO\nIsraeli\tB-MISC\nenvoy\tO\nto\tO\nEgypt\tB-LOC\nand\tO\nright-wing\tO\nLikud\tB-ORG\nparty\tO\npolitician\tO\n.\tO\n\nIsrael\tB-LOC\non\tO\nWednesday\tO\nsent\tO\nSyria\tB-LOC\na\tO\nmessage\tO\n,\tO\nvia\tO\nWashington\tB-LOC\n,\tO\nsaying\tO\nit\tO\nwas\tO\ncommitted\tO\nto\tO\npeace\tO\nand\tO\nwanted\tO\nto\tO\nopen\tO\nnegotiations\tO\nwithout\tO\npreconditions\tO\n.\tO\n\nBut\tO\nit\tO\nslammed\tO\nDamascus\tB-LOC\nfor\tO\ncreating\tO\nwhat\tO\nit\tO\ncalled\tO\na\tO\ndangerous\tO\natmosphere\tO\n.\tO\n\nSyria\tB-LOC\naccused\tO\nIsrael\tB-LOC\non\tO\nWednesday\tO\nof\tO\nlaunching\tO\na\tO\nhysterical\tO\ncampaign\tO\nagainst\tO\nit\tO\nafter\tO\nIsraeli\tB-MISC\ntelevision\tO\nreported\tO\nthat\tO\nDamascus\tB-LOC\nhad\tO\nrecently\tO\ntest\tO\nfired\tO\na\tO\nmissile\tO\n.\tO\n\n\"\tO\nThe\tO\nmessage\tO\nthat\tO\nwe\tO\nsent\tO\nto\tO\n(\tO\nSyrian\tB-MISC\nPresident\tO\nHafez\tB-PER\nal-\tI-PER\n)\tO\nAssad\tB-PER\nis\tO\nthat\tO\nIsrael\tB-LOC\nis\tO\nready\tO\nat\tO\nany\tO\ntime\tO\nwithout\tO\npreconditions\tO\nto\tO\nenter\tO\npeace\tO\nnegotiations\tO\n,\tO\n\"\tO\nIsraeli\tB-MISC\nForeign\tO\nMinister\tO\nDavid\tB-PER\nLevy\tI-PER\ntold\tO\nIsrael\tB-ORG\nRadio\tI-ORG\nin\tO\nan\tO\ninterview\tO\n.\tO\n\nTension\tO\nhas\tO\nmounted\tO\nsince\tO\nIsraeli\tB-MISC\nPrime\tO\nMinister\tO\nBenjamin\tB-PER\nNetanyahu\tI-PER\ntook\tO\noffice\tO\nin\tO\nJune\tO\nvowing\tO\nto\tO\nretain\tO\nthe\tO\nGolan\tB-LOC\nHeights\tI-LOC\nIsrael\tB-LOC\ncaptured\tO\nfrom\tO\nSyria\tB-LOC\nin\tO\nthe\tO\n1967\tO\nMiddle\tB-LOC\nEast\tI-LOC\nwar\tO\n.\tO\n\nIsraeli-Syrian\tB-MISC\npeace\tO\ntalks\tO\nhave\tO\nbeen\tO\ndeadlocked\tO\nover\tO\nthe\tO\nGolan\tB-LOC\nsince\tO\n1991\tO\ndespite\tO\nthe\tO\nprevious\tO\ngovernment\tO\n's\tO\nwillingness\tO\nto\tO\nmake\tO\nGolan\tB-LOC\nconcessions\tO\n.\tO\n\n\"\tO\nThe\tO\nvoices\tO\ncoming\tO\nout\tO\nof\tO\nDamascus\tB-LOC\nare\tO\nbad\tO\n,\tO\nnot\tO\ngood\tO\n.\tO\n\n\"\tO\nWe\tO\nexpect\tO\nfrom\tO\nSyria\tB-LOC\n,\tO\nif\tO\nits\tO\nface\tO\nis\tO\nto\tO\npeace\tO\n,\tO\nthat\tO\nit\tO\nwill\tO\nanswer\tO\nIsrael\tB-LOC\n's\tO\nmessage\tO\nto\tO\nenter\tO\npeace\tO\nnegotiations\tO\nbecause\tO\nthat\tO\nis\tO\nour\tO\ngoal\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\"\tO\n\nWe\tO\ndo\tO\nnot\tO\nwant\tO\na\tO\nwar\tO\n,\tO\nGod\tB-PER\nforbid\tO\n.\tO\n\nIsrael\tB-LOC\n's\tO\nChannel\tB-ORG\nTwo\tI-ORG\ntelevision\tO\nsaid\tO\nDamascus\tB-LOC\nhad\tO\nsent\tO\na\tO\n\"\tO\ncalming\tO\nsignal\tO\n\"\tO\nto\tO\nIsrael\tB-LOC\n.\tO\n\nNetanyahu\tB-PER\nand\tO\nLevy\tB-PER\n's\tO\nspokesmen\tO\nsaid\tO\nthey\tO\ncould\tO\nnot\tO\nconfirm\tO\nit\tO\n.\tO\n\nThe\tO\ntelevision\tO\nalso\tO\nsaid\tO\nthat\tO\nNetanyahu\tB-PER\nhad\tO\nsent\tO\nmessages\tO\nto\tO\nreassure\tO\nSyria\tB-LOC\nvia\tO\nCairo\tB-LOC\n,\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\nand\tO\nMoscow\tB-LOC\n.\tO\n\nPolish\tB-MISC\ndiplomat\tO\ndenies\tO\nnurses\tO\nstranded\tO\nin\tO\nLibya\tB-LOC\n.\tO\n\nA\tO\nPolish\tB-MISC\ndiplomat\tO\non\tO\nThursday\tO\ndenied\tO\na\tO\nPolish\tB-MISC\ntabloid\tO\nreport\tO\nthis\tO\nweek\tO\nthat\tO\nLibya\tB-LOC\nwas\tO\nrefusing\tO\nexit\tO\nvisas\tO\nto\tO\n100\tO\nPolish\tB-MISC\nnurses\tO\ntrying\tO\nto\tO\nreturn\tO\nhome\tO\nafter\tO\nworking\tO\nin\tO\nthe\tO\nNorth\tB-MISC\nAfrican\tI-MISC\ncountry\tO\n.\tO\n\nUp\tO\nto\tO\ntoday\tO\n,\tO\nwe\tO\nhave\tO\nno\tO\nknowledge\tO\nof\tO\nany\tO\nnurse\tO\nstranded\tO\nor\tO\nkept\tO\nin\tO\nLibya\tB-LOC\nwithout\tO\nher\tO\nwill\tO\n,\tO\nand\tO\nwe\tO\nhave\tO\nnot\tO\nreceived\tO\nany\tO\ncomplaint\tO\n,\tO\n\"\tO\nthe\tO\nPolish\tB-MISC\nembassy\tO\n's\tO\ncharge\tO\nd'affaires\tO\nin\tO\nTripoli\tB-LOC\n,\tO\nTadeusz\tB-PER\nAwdankiewicz\tI-PER\n,\tO\ntold\tO\nReuters\tB-ORG\nby\tO\ntelephone\tO\n.\tO\n\nPoland\tB-LOC\n's\tO\nlabour\tO\nministry\tO\nsaid\tO\nthis\tO\nweek\tO\nit\tO\nwould\tO\nsend\tO\na\tO\nteam\tO\nto\tO\nLibya\tB-LOC\nto\tO\ninvestigate\tO\n,\tO\nbut\tO\nAwdankiewicz\tB-PER\nsaid\tO\nthe\tO\nprobe\tO\nwas\tO\nprompted\tO\nby\tO\nsome\tO\nnurses\tO\ncomplaining\tO\nabout\tO\ntheir\tO\nwork\tO\nconditions\tO\nsuch\tO\nas\tO\nnon-payment\tO\nof\tO\ntheir\tO\nsalaries\tO\n.\tO\n\nHe\tO\nsaid\tO\nthat\tO\nthere\tO\nare\tO\nan\tO\nestimated\tO\n800\tO\nPolish\tO\nnurses\tO\nworking\tO\nin\tO\nLibya\tB-LOC\n.\tO\n\nTwo\tO\nIranian\tB-MISC\nopposition\tO\nleaders\tO\nmeet\tO\nin\tO\nBaghdad\tB-LOC\n.\tO\n\nAn\tO\nIranian\tB-MISC\nexile\tO\ngroup\tO\nbased\tO\nin\tO\nIraq\tB-LOC\nvowed\tO\non\tO\nThursday\tO\nto\tO\nextend\tO\nsupport\tO\nto\tO\nIran\tB-LOC\n's\tO\nKurdish\tB-MISC\nrebels\tO\nafter\tO\nthey\tO\nwere\tO\nattacked\tO\nby\tO\nIranian\tB-MISC\ntroops\tO\ndeep\tO\ninside\tO\nIraq\tB-LOC\nlast\tO\nmonth\tO\n.\tO\n\nA\tO\nMujahideen\tO\nKhalq\tO\nstatement\tO\nsaid\tO\nits\tO\nleader\tO\nMassoud\tB-PER\nRajavi\tI-PER\nmet\tO\nin\tO\nBaghdad\tB-LOC\nthe\tO\nSecretary-General\tO\nof\tO\nthe\tO\nKurdistan\tB-ORG\nDemocratic\tI-ORG\nParty\tI-ORG\nof\tI-ORG\nIran\tI-ORG\n(\tO\nKDPI\tB-ORG\n)\tO\nHassan\tB-PER\nRastegar\tI-PER\non\tO\nWednesday\tO\nand\tO\nvoiced\tO\nhis\tO\nsupport\tO\nto\tO\nIran\tB-LOC\n's\tO\nrebel\tO\nKurds\tB-MISC\n.\tO\n\n\"\tO\nRajavi\tB-MISC\nemphasised\tO\nthat\tO\nthe\tO\nIranian\tB-MISC\nResistance\tB-ORG\nwould\tO\ncontinue\tO\nto\tO\nstand\tO\nside\tO\nby\tO\nside\tO\nwith\tO\ntheir\tO\nKurdish\tB-MISC\ncompatriots\tO\nand\tO\nthe\tO\nresistance\tO\nmovement\tO\nin\tO\nIranian\tB-LOC\nKurdistan\tI-LOC\n,\tO\n\"\tO\nit\tO\nsaid\tO\n.\tO\n\nA\tO\nspokesman\tO\nfor\tO\nthe\tO\ngroup\tO\nsaid\tO\nthe\tO\nmeeting\tO\n\"\tO\nsignals\tO\na\tO\nnew\tO\nlevel\tO\nof\tO\ncooperation\tO\nbetween\tO\nMujahideen\tB-ORG\nKhalq\tI-ORG\nand\tO\nthe\tO\nIranian\tB-MISC\nKurdish\tI-MISC\noppositions\tO\n\"\tO\n.\tO\n\nIran\tB-LOC\nheavily\tO\nbombarded\tO\ntargets\tO\nin\tO\nnorthern\tO\nIraq\tB-LOC\nin\tO\nJuly\tO\nin\tO\npursuit\tO\nof\tO\nKDPI\tB-ORG\nguerrillas\tO\nbased\tO\nin\tO\nIraqi\tB-MISC\nKurdish\tI-MISC\nareas\tO\noutside\tO\nthe\tO\ncontrol\tO\nof\tO\nthe\tO\ngovernment\tO\nin\tO\nBaghdad\tB-LOC\n.\tO\n\nIraqi\tB-MISC\nKurdish\tI-MISC\nareas\tO\nbordering\tO\nIran\tB-LOC\nare\tO\nunder\tO\nthe\tO\ncontrol\tO\nof\tO\nguerrillas\tO\nof\tO\nthe\tO\nIraqi\tB-ORG\nKurdish\tI-ORG\nPatriotic\tI-ORG\nUnion\tI-ORG\nof\tI-ORG\nKurdistan\tI-ORG\n(\tO\nPUK\tB-ORG\n)\tO\ngroup\tO\n.\tO\n\nPUK\tB-ORG\nand\tO\nIraq\tB-LOC\n's\tO\nKurdistan\tB-ORG\nDemocratic\tI-ORG\nParty\tI-ORG\n(\tO\nKDP\tB-ORG\n)\tO\nthe\tO\ntwo\tO\nmain\tO\nIraqi\tB-MISC\nKurdish\tI-MISC\nfactions\tO\n,\tO\nhave\tO\nhad\tO\nnorthern\tO\nIraq\tB-LOC\nunder\tO\ntheir\tO\ncontrol\tO\nsince\tO\nIraqi\tB-MISC\nforces\tO\nwere\tO\nousted\tO\nfrom\tO\nKuwait\tB-LOC\nin\tO\nthe\tO\n1991\tO\nGulf\tB-MISC\nWar\tI-MISC\n.\tO\n\nClashes\tO\nbetween\tO\nthe\tO\ntwo\tO\nparties\tO\nbroke\tO\nout\tO\nat\tO\nthe\tO\nweekend\tO\nin\tO\nthe\tO\nmost\tO\nserious\tO\nfighting\tO\nsince\tO\na\tO\nU.S.-sponsored\tB-MISC\nceasefire\tO\nlast\tO\nyear\tO\n.\tO\n\nMujahideen\tB-ORG\nKhalq\tI-ORG\nsaid\tO\nIranian\tB-MISC\ntroops\tO\nhad\tO\nalso\tO\nbeen\tO\nshelling\tO\nKDP\tB-ORG\npositions\tO\nin\tO\nQasri\tB-LOC\nregion\tO\nin\tO\nSuleimaniya\tB-LOC\nprovince\tO\nnear\tO\nthe\tO\nIranian\tB-MISC\nborder\tO\nover\tO\nthe\tO\nlast\tO\ntwo\tO\ndays\tO\n.\tO\n\nIt\tO\nsaid\tO\nabout\tO\n100\tO\nIraqi\tB-MISC\nKurds\tI-MISC\nwere\tO\nkilled\tO\nor\tO\nwounded\tO\nin\tO\nthe\tO\nattack\tO\n.\tO\n\nBoth\tO\nIran\tB-LOC\nand\tO\nTurkey\tB-LOC\nmount\tO\nair\tO\nand\tO\nland\tO\nstrikes\tO\nat\tO\ntargets\tO\nin\tO\nnorthern\tO\nIraq\tB-LOC\nin\tO\npursuit\tO\nof\tO\ntheir\tO\nown\tO\nKurdish\tB-MISC\nrebels\tO\n.\tO\n\nA\tO\nU.S.-led\tB-MISC\nair\tO\nforce\tO\nin\tO\nsouthern\tO\nTurkey\tB-LOC\nprotects\tO\nIraqi\tB-MISC\nKurds\tI-MISC\nfrom\tO\npossible\tO\nattacks\tO\nby\tO\nBaghdad\tB-LOC\ntroops\tO\n.\tO\n\nSaudi\tB-MISC\nriyal\tO\nrates\tO\nsteady\tO\nin\tO\nquiet\tO\nsummer\tO\ntrade\tO\n.\tO\n\nThe\tO\nspot\tO\nSaudi\tB-MISC\nriyal\tO\nagainst\tO\nthe\tO\ndollar\tO\nand\tO\nriyal\tO\ninterbank\tO\ndeposit\tO\nrates\tO\nwere\tO\nmainly\tO\nsteady\tO\nthis\tO\nweek\tO\nin\tO\nquiet\tO\nsummer\tO\ntrade\tO\n,\tO\ndealers\tO\nin\tO\nthe\tO\nkingdom\tO\nsaid\tO\n.\tO\n\n\"\tO\nThere\tO\nwere\tO\nno\tO\nchanges\tO\nin\tO\nSaudi\tB-MISC\nriyal\tO\nrates\tO\n.\tO\n\nOne-month\tB-MISC\ninterbank\tO\ndeposits\tO\nwere\tO\nat\tO\n5-1/2\tO\n,\tO\n3/8\tO\npercent\tO\n,\tO\nthree\tO\nmonths\tO\nwere\tO\n5-5/8\tO\n,\tO\n1/2\tO\npercent\tO\nand\tO\nsix\tO\nmonths\tO\nwere\tO\n5-3/4\tO\n,\tO\n5/8\tO\npercent\tO\n.\tO\n\nOne-year\tB-MISC\nfunds\tO\nwere\tO\nat\tO\nsix\tO\n,\tO\n5-7/8\tO\npercent\tO\n.\tO\n\nIsrael\tB-LOC\napproves\tO\nArafat\tB-PER\n's\tO\nflight\tO\nto\tO\nWest\tB-LOC\nBank\tI-LOC\n.\tO\n\nIsrael\tB-LOC\ngave\tO\nPalestinian\tB-MISC\nPresident\tO\nYasser\tB-PER\nArafat\tI-PER\npermission\tO\non\tO\nThursday\tO\nto\tO\nfly\tO\nover\tO\nits\tO\nterritory\tO\nto\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\n,\tO\nending\tO\na\tO\nbrief\tO\nIsraeli-PLO\tB-MISC\ncrisis\tO\n,\tO\nan\tO\nArafat\tB-PER\nadviser\tO\nsaid\tO\n.\tO\n\nThe\tO\npresident\tO\n's\tO\naircraft\tO\nhas\tO\nreceived\tO\npermission\tO\nto\tO\npass\tO\nthrough\tO\nIsraeli\tB-MISC\nairspace\tO\nbut\tO\nthe\tO\npresident\tO\nis\tO\nnot\tO\nexpected\tO\nto\tO\ntravel\tO\nto\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\nbefore\tO\nMonday\tO\n,\tO\n\"\tO\nNabil\tB-PER\nAbu\tI-PER\nRdainah\tI-PER\ntold\tO\nReuters\tB-ORG\n.\tO\n\nArafat\tB-PER\nhad\tO\nbeen\tO\nscheduled\tO\nto\tO\nmeet\tO\nformer\tO\nIsraeli\tB-MISC\nprime\tO\nminister\tO\nShimon\tB-PER\nPeres\tI-PER\nin\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\ntown\tO\nof\tO\nRamallah\tB-LOC\non\tO\nThursday\tO\nbut\tO\nthe\tO\nvenue\tO\nwas\tO\nchanged\tO\nto\tO\nGaza\tB-LOC\nafter\tO\nIsrael\tB-LOC\ndenied\tO\nflight\tO\nclearance\tO\nto\tO\nthe\tO\nPalestinian\tB-MISC\nleader\tO\n's\tO\nhelicopters\tO\n.\tO\n\nPalestinian\tB-MISC\nofficials\tO\naccused\tO\nright-wing\tO\nPrime\tO\nMinister\tO\nBenjamin\tB-PER\nNetanyahu\tI-PER\nof\tO\ntrying\tO\nto\tO\nstop\tO\nthe\tO\nRamallah\tB-LOC\nmeeting\tO\nby\tO\nkeeping\tO\nArafat\tB-PER\ngrounded\tO\n.\tO\n\nArafat\tB-PER\nsubsequently\tO\ncancelled\tO\na\tO\nmeeting\tO\nbetween\tO\nIsraeli\tB-MISC\nand\tO\nPLO\tB-ORG\nofficials\tO\n,\tO\non\tO\ncivilian\tO\naffairs\tO\n,\tO\nat\tO\nthe\tO\nAllenby\tB-LOC\nBridge\tI-LOC\ncrossing\tO\nbetween\tO\nJordan\tB-LOC\nand\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\n.\tO\n\nAbu\tB-PER\nRdainah\tI-PER\nsaid\tO\nArafat\tB-PER\nhad\tO\ndecided\tO\nagainst\tO\nflying\tO\nto\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\non\tO\nThursday\tO\n,\tO\nafter\tO\nIsrael\tB-LOC\nlifted\tO\nthe\tO\nban\tO\n,\tO\nbecause\tO\nhe\tO\nhad\tO\na\tO\nbusy\tO\nschedule\tO\nin\tO\nGaza\tB-LOC\nand\tO\nwould\tO\nnot\tO\nbe\tO\nfree\tO\nuntil\tO\nMonday\tO\n.\tO\n\nArafat\tB-PER\nto\tO\nmeet\tO\nPeres\tB-PER\nin\tO\nGaza\tB-LOC\nafter\tO\nflight\tO\nban\tO\n.\tO\n\nYasser\tB-PER\nArafat\tI-PER\nwill\tO\nmeet\tO\nShimon\tB-PER\nPeres\tI-PER\nin\tO\nGaza\tB-LOC\non\tO\nThursday\tO\nafter\tO\nPalestinians\tB-MISC\nsaid\tO\nthe\tO\nright-wing\tO\nIsraeli\tB-MISC\ngovernment\tO\nhad\tO\nbarred\tO\nthe\tO\nPalestinian\tB-MISC\nleader\tO\nfrom\tO\nflying\tO\nto\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\nfor\tO\ntalks\tO\nwith\tO\nthe\tO\nformer\tO\nprime\tO\nminister\tO\n.\tO\n\n\"\tO\nThe\tO\nmeeting\tO\nbetween\tO\nPeres\tB-PER\nand\tO\nArafat\tB-PER\nwill\tO\ntake\tO\nplace\tO\nat\tO\nErez\tB-LOC\ncheckpoint\tO\nin\tO\nGaza\tB-LOC\nand\tO\nnot\tO\nin\tO\nRamallah\tB-LOC\nas\tO\nplanned\tO\n,\tO\n\"\tO\nPeres\tB-PER\n'\tO\noffice\tO\nsaid\tO\n.\tO\n\nPalestinian\tB-MISC\nofficials\tO\nsaid\tO\nthe\tO\nIsraeli\tB-MISC\ngovernment\tO\nhad\tO\nbarred\tO\nArafat\tB-PER\nfrom\tO\noverflying\tO\nIsrael\tB-LOC\nin\tO\na\tO\nPalestinian\tB-MISC\nhelicopter\tO\nto\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\nin\tO\nan\tO\nattempt\tO\nto\tO\nbar\tO\nthe\tO\nmeeting\tO\nwith\tO\nPeres\tB-PER\n.\tO\n\nIsraeli\tB-MISC\nPrime\tO\nMinister\tO\nBenjamin\tB-PER\nNetanyahu\tI-PER\nhas\tO\naccused\tO\nopposition\tO\nleader\tO\nPeres\tB-PER\n,\tO\nwho\tO\nhe\tO\ndefeated\tO\nin\tO\nMay\tO\nelections\tO\n,\tO\nof\tO\ntrying\tO\nto\tO\nundermine\tO\nhis\tO\nLikud\tB-ORG\ngovernment\tO\n's\tO\nauthority\tO\nto\tO\nconduct\tO\npeace\tO\ntalks\tO\n.\tO\n\nAfghan\tB-MISC\nUAE\tB-LOC\nembassy\tO\nsays\tO\nTaleban\tB-MISC\nguards\tO\ngoing\tO\nhome\tO\n.\tO\n\nThree\tO\nAfghan\tB-MISC\nguards\tO\nbrought\tO\nto\tO\nthe\tO\nUnited\tB-LOC\nArab\tI-LOC\nEmirates\tI-LOC\nlast\tO\nweek\tO\nby\tO\nRussian\tB-MISC\nhostages\tO\nwho\tO\nescaped\tO\nfrom\tO\nthe\tO\nTaleban\tB-MISC\nmilitia\tO\nwill\tO\nreturn\tO\nto\tO\nAfghanistan\tB-LOC\nin\tO\na\tO\nfew\tO\ndays\tO\n,\tO\nthe\tO\nAfghan\tB-MISC\nembassy\tO\nin\tO\nAbu\tB-LOC\nDhabi\tI-LOC\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nOur\tO\nambassador\tO\nis\tO\nin\tO\ntouch\tO\nwith\tO\nthe\tO\nUAE\tB-LOC\nforeign\tO\nministry\tO\n.\tO\n\nTheir\tO\nreturn\tO\nto\tO\nAfghanistan\tB-LOC\nwill\tO\ntake\tO\nplace\tO\nin\tO\ntwo\tO\nor\tO\nthree\tO\ndays\tO\n,\tO\n\"\tO\nan\tO\nembassy\tO\nofficial\tO\nsaid\tO\n.\tO\n\nThe\tO\nthree\tO\nIslamic\tB-MISC\nTaleban\tI-MISC\nguards\tO\nwere\tO\noverpowered\tO\nby\tO\nseven\tO\nRussian\tB-MISC\naircrew\tO\nwho\tO\nescaped\tO\nto\tO\nUAE\tB-LOC\nstate\tO\nSharjah\tB-LOC\nlast\tO\nFriday\tO\non\tO\nboard\tO\ntheir\tO\nown\tO\naircraft\tO\nafter\tO\na\tO\nyear\tO\nin\tO\nthe\tO\ncaptivity\tO\nof\tO\nTaleban\tB-MISC\nmilitia\tO\nin\tO\nKandahar\tB-LOC\nin\tO\nsouthern\tO\nAfghanistan\tB-LOC\n.\tO\n\nThe\tO\nUAE\tB-LOC\nsaid\tO\non\tO\nMonday\tO\nit\tO\nwould\tO\nhand\tO\nover\tO\nthe\tO\nthree\tO\nto\tO\nthe\tO\nInternational\tB-ORG\nRed\tI-ORG\nCrescent\tI-ORG\n,\tO\npossibly\tO\nlast\tO\nTuesday\tO\n.\tO\n\nWhen\tO\nasked\tO\nwhether\tO\nthe\tO\nthree\tO\nguards\tO\nwould\tO\ntravel\tO\nback\tO\nto\tO\nKandahar\tB-LOC\nor\tO\nthe\tO\nAfghan\tB-MISC\ncapital\tO\nKabul\tO\n,\tO\nthe\tO\nembassy\tO\nofficial\tO\nsaid\tO\n:\tO\n\"\tO\nThat\tO\nhas\tO\nnot\tO\nbeen\tO\ndecided\tO\n,\tO\nbut\tO\npossibly\tO\nKandahar\tB-LOC\n.\tO\n\"\tO\n\nKandahar\tB-LOC\nis\tO\nthe\tO\nheadquarters\tO\nof\tO\nthe\tO\nopposition\tO\nTaleban\tB-MISC\nmilitia\tO\n.\tO\n\nKabul\tB-LOC\nis\tO\ncontrolled\tO\nby\tO\nPresident\tO\nBurhanuddin\tB-PER\nRabbani\tI-PER\n's\tO\ngovernment\tO\n,\tO\nwhich\tO\nTaleban\tB-MISC\nis\tO\nfighting\tO\nto\tO\noverthrow\tO\n.\tO\n\nThe\tO\nembassy\tO\nofficial\tO\nsaid\tO\nthe\tO\nthree\tO\nmen\tO\n,\tO\nbelieved\tO\nto\tO\nbe\tO\nin\tO\ntheir\tO\n20s\tO\n,\tO\nwere\tO\ncurrently\tO\nin\tO\nAbu\tB-LOC\nDhabi\tI-LOC\n.\tO\n\nThe\tO\nRussians\tB-MISC\n,\tO\nworking\tO\nfor\tO\nthe\tO\nAerostan\tB-ORG\nfirm\tO\nin\tO\nthe\tO\nRussian\tB-MISC\nrepublic\tO\nof\tO\nTatarstan\tB-LOC\n,\tO\nwere\tO\ntaken\tO\nhostage\tO\nafter\tO\na\tO\nTaleban\tB-MISC\nMiG-19\tB-MISC\nfighter\tO\nforced\tO\ntheir\tO\ncargo\tO\nplane\tO\nto\tO\nland\tO\nin\tO\nAugust\tO\n1995\tO\n.\tO\n\nTaleban\tB-MISC\nsaid\tO\nits\tO\nshipment\tO\nof\tO\nammunition\tO\nfrom\tO\nAlbania\tB-LOC\nwas\tO\nevidence\tO\nof\tO\nRussian\tB-MISC\nmilitary\tO\nsupport\tO\nfor\tO\nRabbani\tB-PER\n's\tO\ngovernment\tO\n.\tO\n\nThe\tO\nRussians\tB-MISC\n,\tO\nwho\tO\nsaid\tO\nthey\tO\noverpowered\tO\nthe\tO\nguards\tO\n--\tO\ntwo\tO\narmed\tO\nwith\tO\nKalashnikov\tB-MISC\nautomatic\tO\nrifles\tO\n--\tO\nwhile\tO\ndoing\tO\nregular\tO\nmaintenance\tO\nwork\tO\non\tO\ntheir\tO\nIlyushin\tB-MISC\n76\tI-MISC\ncargo\tO\nplane\tO\nlast\tO\nFriday\tO\n,\tO\nleft\tO\nthe\tO\nUAE\tB-LOC\ncapital\tO\nAbu\tB-LOC\nDhabi\tI-LOC\nfor\tO\nhome\tO\non\tO\nSunday\tO\n.\tO\n\nIraq\tB-LOC\n's\tO\nSaddam\tB-PER\nmeets\tO\nRussia\tB-LOC\n's\tO\nZhirinovsky\tB-PER\n.\tO\n\nIraqi\tB-MISC\nPresident\tO\nSaddam\tB-PER\nHussein\tI-PER\nhas\tO\ntold\tO\nvisiting\tO\nRussian\tB-MISC\nultra-nationalist\tO\nVladimir\tB-PER\nZhirinovsky\tI-PER\nthat\tO\nBaghdad\tB-LOC\nwanted\tO\nto\tO\nmaintain\tO\n\"\tO\nfriendship\tO\nand\tO\ncooperation\tO\n\"\tO\nwith\tO\nMoscow\tB-LOC\n,\tO\nofficial\tO\nIraqi\tB-MISC\nnewspapers\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nPresident\tO\nSaddam\tB-PER\nHussein\tI-PER\nstressed\tO\nduring\tO\nthe\tO\nmeeting\tO\nIraq\tB-LOC\n's\tO\nkeenness\tO\nto\tO\nmaintain\tO\nfriendship\tO\nand\tO\ncooperation\tO\nwith\tO\nRussia\tB-LOC\n,\tO\n\"\tO\nthe\tO\npapers\tO\nsaid\tO\n.\tO\n\nThey\tO\nsaid\tO\nZhirinovsky\tB-PER\ntold\tO\nSaddam\tB-PER\nbefore\tO\nhe\tO\nleft\tO\nBaghdad\tB-LOC\non\tO\nWednesday\tO\nthat\tO\nhis\tO\nLiberal\tB-ORG\nDemocratic\tI-ORG\nparty\tI-ORG\nand\tO\nthe\tO\nRussian\tB-MISC\nDuma\tB-ORG\n(\tO\nparliament\tO\n)\tO\n\"\tO\nare\tO\ncalling\tO\nfor\tO\nan\tO\nimmediate\tO\nlifting\tO\nof\tO\nthe\tO\nembargo\tO\n\"\tO\nimposed\tO\non\tO\nIraq\tB-LOC\nafter\tO\nits\tO\n1990\tO\ninvasion\tO\nof\tO\nKuwait\tB-LOC\n.\tO\n\nZhirinovsky\tB-PER\nsaid\tO\non\tO\nTuesday\tO\nhe\tO\nwould\tO\npress\tO\nthe\tO\nRussian\tB-MISC\ngovernment\tO\nto\tO\nhelp\tO\nend\tO\nU.N.\tB-ORG\ntrade\tO\nsanctions\tO\non\tO\nIraq\tB-LOC\nand\tO\nblamed\tO\nMoscow\tB-LOC\nfor\tO\ndelaying\tO\nestablishment\tO\nof\tO\ngood\tO\nties\tO\nwith\tO\nBaghdad\tB-LOC\n.\tO\n\n\"\tO\nOur\tO\nstand\tO\nis\tO\nfirm\tO\n,\tO\nnamely\tO\nwe\tO\nare\tO\ncalling\tO\non\tO\n(\tO\nthe\tO\nRussian\tB-MISC\n)\tO\ngovernment\tO\nto\tO\nend\tO\nthe\tO\neconomic\tO\nembargo\tO\non\tO\nIraq\tB-LOC\nand\tO\nresume\tO\ntrade\tO\nties\tO\nbetween\tO\nRussia\tB-LOC\nand\tO\nIraq\tB-LOC\n,\tO\n\"\tO\nhe\tO\ntold\tO\nreporters\tO\n.\tO\n\nZhirinovsky\tO\nvisited\tO\nIraq\tB-LOC\ntwice\tO\nin\tO\n1995\tO\n.\tO\n\nLast\tO\nOctober\tO\nhe\tO\nwas\tO\ninvited\tO\nto\tO\nattend\tO\nthe\tO\nreferendum\tO\nheld\tO\non\tO\nIraq\tB-LOC\n's\tO\npresidency\tO\n,\tO\nwhich\tO\nextended\tO\nSaddam\tB-PER\n's\tO\nterm\tO\nfor\tO\nseven\tO\nmore\tO\nyears\tO\n.\tO\n\nPRESS\tO\nDIGEST\tO\n-\tO\nIraq\tB-LOC\n-\tO\nAug\tO\n22\tO\n.\tO\n\nThese\tO\nare\tO\nsome\tO\nof\tO\nthe\tO\nleading\tO\nstories\tO\nin\tO\nthe\tO\nofficial\tO\nIraqi\tB-MISC\npress\tO\non\tO\nThursday\tO\n.\tO\n\nReuters\tB-ORG\nhas\tO\nnot\tO\nverified\tO\nthese\tO\nstories\tO\nand\tO\ndoes\tO\nnot\tO\nvouch\tO\nfor\tO\ntheir\tO\naccuracy\tO\n.\tO\n\n-\tO\nIraq\tB-LOC\n's\tO\nPresident\tO\nSaddam\tB-PER\nHussein\tI-PER\nmeets\tO\nwith\tO\nchairman\tO\nof\tO\nthe\tO\nRussian\tB-MISC\nliberal\tO\ndemocratic\tO\nparty\tO\nVladimir\tB-PER\nZhirinovsky\tI-PER\n.\tO\n\n-\tO\nTurkish\tB-MISC\nforeign\tO\nminister\tO\nsays\tO\nTurkey\tB-LOC\nwill\tO\ntake\tO\npart\tO\nin\tO\nthe\tO\nBaghdad\tB-LOC\ntrade\tO\nfair\tO\nthat\tO\nwill\tO\nbe\tO\nheld\tO\nin\tO\nNovember\tO\n.\tO\n\n-\tO\nA\tO\nshipload\tO\nof\tO\n12\tO\ntonnes\tO\nof\tO\nrice\tO\narrives\tO\nin\tO\nUmm\tB-LOC\nQasr\tI-LOC\nport\tO\nin\tO\nthe\tO\nGulf\tB-LOC\n.\tO\n\nPRESS\tO\nDIGEST\tO\n-\tO\nLebanon\tB-LOC\n-\tO\nAug\tO\n22\tO\n.\tO\n\nThese\tO\nare\tO\nthe\tO\nleading\tO\nstories\tO\nin\tO\nthe\tO\nBeirut\tB-LOC\npress\tO\non\tO\nThursday\tO\n.\tO\n\n-\tO\nConfrontation\tO\nis\tO\nescalating\tO\nbetween\tO\nHizbollah\tB-ORG\nand\tO\nthe\tO\ngovernment\tO\n.\tO\n\n-\tO\nPrime\tO\nMinister\tO\nHariri\tB-PER\n:\tO\nIsraeli\tB-MISC\nthreats\tO\ndo\tO\nno\tO\nserve\tO\npeace\tO\n.\tO\n\n-\tO\nParliament\tO\nSpeaker\tO\nBerri\tB-PER\n:\tO\nIsrael\tB-LOC\nis\tO\npreparing\tO\nfor\tO\nwar\tO\nagainst\tO\nSyria\tB-LOC\nand\tO\nLebanon\tB-LOC\n.\tO\n\n-\tO\nParliamentary\tO\nbattle\tO\nin\tO\nBeirut\tB-LOC\n..\tO\n\n-\tO\nContinued\tO\ncriticism\tO\nof\tO\nlaw\tO\nviolation\tO\nincidents\tO\n--\tO\nwhich\tO\noccurred\tO\nin\tO\nthe\tO\nMount\tB-LOC\nLebanon\tI-LOC\nelections\tO\nlast\tO\nSunday\tO\n.\tO\n\n-\tO\nFinancial\tO\nnegotiations\tO\nbetween\tO\nLebanon\tB-LOC\nand\tO\nPakistan\tO\n.\tO\n\n-\tO\nHariri\tB-PER\nto\tO\nstep\tO\ninto\tO\nthe\tO\nelection\tO\nbattle\tO\nwith\tO\nan\tO\nincomplete\tO\nlist\tO\n.\tO\n\n-\tO\nMaronite\tB-ORG\nPatriarch\tO\nSfeir\tB-PER\nexpressed\tO\nsorrow\tO\nover\tO\nthe\tO\nviolations\tO\nin\tO\nSunday\tO\n'\tO\nelections\tO\n.\tO\n\nCME\tB-ORG\nlive\tO\nand\tO\nfeeder\tO\ncattle\tO\ncalls\tO\nrange\tO\nmixed\tO\n.\tO\n\nEarly\tO\ncalls\tO\non\tO\nCME\tB-ORG\nlive\tO\nand\tO\nfeeder\tO\ncattle\tO\nfutures\tO\nranged\tO\nfrom\tO\n0.200\tO\ncent\tO\nhigher\tO\nto\tO\n0.100\tO\nlower\tO\n,\tO\nlivestock\tO\nanalysts\tO\nsaid\tO\n.\tO\n\nMONTGOMERY\tB-LOC\n,\tO\nAla\tB-LOC\n.\tO\n\nKinderCare\tB-ORG\nLearning\tI-ORG\nCenters\tI-ORG\nInc\tI-ORG\nsaid\tO\non\tO\nThursday\tO\nthat\tO\na\tO\ndebt\tO\nbuyback\tO\nwould\tO\nmean\tO\nan\tO\nextraordinary\tO\nloss\tO\nof\tO\n$\tO\n1.2\tO\nmillion\tO\nin\tO\nits\tO\nfiscal\tO\n1997\tO\nfirst\tO\nquarter\tO\n.\tO\n\nPhilip\tB-PER\nMaslowe\tI-PER\n,\tO\nchief\tO\nfinancial\tO\nofficer\tO\nof\tO\nthe\tO\npreschool\tO\nand\tO\nchild\tO\ncare\tO\ncompany\tO\n,\tO\nsaid\tO\nthe\tO\nbuyback\tO\n\"\tO\noffered\tO\nan\tO\nopportunity\tO\nto\tO\nreduce\tO\nthe\tO\ncompany\tO\n's\tO\nweighted\tO\naverage\tO\ninterest\tO\ncosts\tO\nand\tO\nimprove\tO\nfuture\tO\ncash\tO\nflows\tO\nand\tO\nearnings\tO\n.\tO\n\"\tO\n\nRESEARCH\tO\nALERT\tO\n-\tO\nLehman\tB-ORG\nstarts\tO\nSNET\tB-ORG\n.\tO\n\n--\tO\nLehman\tB-ORG\nanalyst\tO\nBlake\tB-PER\nBath\tI-PER\nstarted\tO\nSouthern\tB-ORG\nNew\tI-ORG\nEngland\tI-ORG\nTelecommunciations\tI-ORG\nCorp\tI-ORG\nwith\tO\nan\tO\noutperform\tO\nrating\tO\n,\tO\nhis\tO\noffice\tO\nsaid\tO\n.\tO\n\n--\tO\nE.\tO\nAuchard\tO\n,\tO\nWall\tB-ORG\nStreet\tI-ORG\nbureau\tI-ORG\n,\tO\n212-859-1736\tO\n\nGreek\tB-MISC\nsocialists\tO\ngive\tO\nPM\tO\ngreen\tO\nlight\tO\nfor\tO\nelection\tO\n.\tO\n\nThe\tO\nGreek\tB-MISC\nsocialist\tO\nparty\tO\n's\tO\nexecutive\tO\nbureau\tO\ngave\tO\nPrime\tO\nMinister\tO\nCostas\tB-PER\nSimitis\tI-PER\nits\tO\nbacking\tO\nif\tO\nhe\tO\nchooses\tO\nto\tO\ncall\tO\nsnap\tO\nelections\tO\n,\tO\nits\tO\ngeneral\tO\nsecretary\tO\nCostas\tB-PER\nSkandalidis\tI-PER\ntold\tO\nreporters\tO\non\tO\nThursday\tO\n.\tO\n\nPrime\tO\nMinister\tO\nCostas\tB-PER\nSimitis\tI-PER\nwill\tO\nmake\tO\nan\tO\nofficial\tO\nannouncement\tO\nafter\tO\na\tO\ncabinet\tO\nmeeting\tO\nlater\tO\non\tO\nThursday\tO\n,\tO\nsaid\tO\nSkandalidis\tB-PER\n.\tO\n\nPRESS\tO\nDIGEST\tO\n-\tO\nFrance\tB-LOC\n-\tO\nLe\tB-ORG\nMonde\tI-ORG\nAug\tO\n22\tO\n.\tO\n\n--\tO\nAfricans\tO\nseeking\tO\nto\tO\nrenew\tO\nor\tO\nobtain\tO\nwork\tO\nand\tO\nresidence\tO\nrights\tO\nsay\tO\nPrime\tO\nMinister\tO\nAlain\tB-PER\nJuppe\tI-PER\n's\tO\nproposals\tO\nare\tO\ninsufficient\tO\nas\tO\nhunger\tO\nstrike\tO\nenters\tO\n49th\tO\nday\tO\nin\tO\nParis\tB-LOC\nchurch\tO\nand\tO\nWednesday\tO\nrally\tO\nattracts\tO\n8,000\tO\nsympathisers\tO\n.\tO\n\n--\tO\nFLNC\tB-ORG\nCorsican\tB-MISC\nnationalist\tO\nmovement\tO\nannounces\tO\nend\tO\nof\tO\ntruce\tO\nafter\tO\nlast\tO\nnight\tO\n's\tO\nattacks\tO\n.\tO\n\n--\tO\nShutdown\tO\nof\tO\nBally\tB-ORG\n's\tO\nFrench\tB-MISC\nfactories\tO\npoints\tO\nup\tO\nshoe\tO\nindustry\tO\ncrisis\tO\n,\tO\nwith\tO\nFrench\tB-MISC\nmanufacturers\tO\nundercut\tO\nby\tO\nlow-wage\tO\ncountry\tO\ncompetition\tO\nand\tO\nfailure\tO\nto\tO\nkeep\tO\nabreast\tO\nof\tO\ntrends\tO\n.\tO\n\n--\tO\nSecretary\tO\ngeneral\tO\nof\tO\nthe\tO\nSud-PTT\tB-MISC\ntrade\tO\nunion\tO\nat\tO\nFrance\tB-ORG\nTelecom\tI-ORG\nall\tO\nthe\tO\nelements\tO\nare\tO\nin\tO\nplace\tO\nfor\tO\nsocial\tO\nunrest\tO\nin\tO\nthe\tO\nnext\tO\nfew\tO\nweeks\tO\n.\tO\n\n--\tO\nParis\tB-ORG\nNewsroom\tI-ORG\n+33\tO\n1\tO\n42\tO\n21\tO\n53\tO\n81\tO\n\nWell\tO\nrepairs\tO\nto\tO\nlift\tO\nHeidrun\tB-LOC\noil\tO\noutput\tO\n-\tO\nStatoil\tB-ORG\n.\tO\n\nThree\tO\nplugged\tO\nwater\tO\ninjection\tO\nwells\tO\non\tO\nthe\tO\nHeidrun\tB-LOC\noilfield\tO\noff\tO\nmid-Norway\tB-MISC\nwill\tO\nbe\tO\nreopened\tO\nover\tO\nthe\tO\nnext\tO\nmonth\tO\n,\tO\noperator\tO\nDen\tB-ORG\nNorske\tI-ORG\nStats\tI-ORG\nOljeselskap\tI-ORG\nAS\tI-ORG\n(\tO\nStatoil\tB-ORG\n)\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nplugged\tO\nwells\tO\nhave\tO\naccounted\tO\nfor\tO\na\tO\ndip\tO\nof\tO\n30,000\tO\nbarrels\tO\nper\tO\nday\tO\n(\tO\nbpd\tO\n)\tO\nin\tO\nHeidrun\tB-LOC\noutput\tO\nto\tO\nroughly\tO\n220,000\tO\nbpd\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\ncompany\tO\n's\tO\nStatus\tB-ORG\nWeekly\tI-ORG\nnewsletter\tO\n.\tO\n\n--\tO\nOslo\tB-LOC\nnewsroom\tO\n+47\tO\n22\tO\n42\tO\n50\tO\n41\tO\n\nFinnish\tB-MISC\nApril\tO\ntrade\tO\nsurplus\tO\n3.8\tO\nbillion\tO\nmarkka\tO\n-\tO\nNCB\tB-ORG\n.\tO\n\nFinland\tB-LOC\n's\tO\ntrade\tO\nsurplus\tO\nrose\tO\nto\tO\n3.83\tO\nbillion\tO\nmarkka\tO\nin\tO\nApril\tO\nfrom\tO\n3.43\tO\nbillion\tO\nin\tO\nMarch\tO\n,\tO\nthe\tO\nNational\tB-ORG\nCustoms\tI-ORG\nBoard\tI-ORG\n(\tO\nNCB\tB-ORG\n)\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nvalue\tO\nof\tO\nexports\tO\nfell\tO\none\tO\npercent\tO\nyear-on-year\tO\nin\tO\nApril\tO\nand\tO\nthe\tO\nvalue\tO\nof\tO\nimports\tO\nfell\tO\ntwo\tO\npercent\tO\n,\tO\nNCB\tB-ORG\nsaid\tO\n.\tO\n\nThe\tO\nBank\tB-ORG\nof\tI-ORG\nFinland\tI-ORG\nearlier\tO\nestimated\tO\nthe\tO\nApril\tO\ntrade\tO\nsurplus\tO\nat\tO\n3.2\tO\nbillion\tO\nmarkka\tO\nwith\tO\nexports\tO\nprojected\tO\nat\tO\n14.5\tO\nbillion\tO\nand\tO\nimports\tO\nat\tO\n11.3\tO\nbillion\tO\n.\tO\n\nThe\tO\nNCB\tB-ORG\n's\tO\nofficial\tO\nmonthly\tO\ntrade\tO\nstatistics\tO\nare\tO\nlagging\tO\nbehind\tO\ndue\tO\nto\tO\nchanges\tO\nin\tO\ncustoms\tO\nprocedures\tO\nwhen\tO\nFinland\tB-LOC\njoined\tO\nthe\tO\nEuropean\tB-ORG\nUnion\tI-ORG\nat\tO\nthe\tO\nstart\tO\nof\tO\n1995\tO\n.\tO\n\n--\tO\nHelsinki\tB-ORG\nNewsroom\tI-ORG\n+358\tO\n-\tO\n0\tO\n-\tO\n680\tO\n50\tO\n245\tO\n\nDutch\tB-MISC\nstate\tO\nraises\tO\ntap\tO\nsale\tO\nprice\tO\nto\tO\n99.95\tO\n.\tO\n\nThe\tO\nFinance\tB-ORG\nMinistry\tI-ORG\nraised\tO\nthe\tO\nprice\tO\nfor\tO\ntap\tO\nsales\tO\nof\tO\nthe\tO\nDutch\tB-MISC\ngovernment\tO\n's\tO\nnew\tO\n5.75\tO\npercent\tO\nbond\tO\ndue\tO\nSeptember\tO\n2002\tO\nto\tO\n99.95\tO\nfrom\tO\n99.90\tO\n.\tO\n\nTap\tO\nsales\tO\nbegan\tO\non\tO\nMonday\tO\nand\tO\nare\tO\nbeing\tO\nheld\tO\ndaily\tO\nfrom\tO\n07.00\tO\nGMT\tB-MISC\nto\tO\n15.00\tO\nGMT\tB-MISC\nuntil\tO\nfurther\tO\nnotice\tO\n.\tO\n\n--\tO\nAmsterdam\tB-LOC\nnewsroom\tO\n+31\tO\n20\tO\n504\tO\n5000\tO\n\nGerman\tB-MISC\nfarm\tO\nministry\tO\ntells\tO\nconsumers\tO\nto\tO\navoid\tO\nBritish\tB-MISC\nmutton\tO\n.\tO\n\nGermany\tB-LOC\n's\tO\nAgriculture\tB-ORG\nMinistry\tI-ORG\nsuggested\tO\non\tO\nWednesday\tO\nthat\tO\nconsumers\tO\navoid\tO\neating\tO\nmeat\tO\nfrom\tO\nBritish\tB-MISC\nsheep\tO\nuntil\tO\nscientists\tO\ndetermine\tO\nwhether\tO\nmad\tO\ncow\tO\ndisease\tO\ncan\tO\nbe\tO\ntransmitted\tO\nto\tO\nthe\tO\nanimals\tO\n.\tO\n\n\"\tO\nUntil\tO\nthis\tO\nis\tO\ncleared\tO\nup\tO\nby\tO\nthe\tO\nEuropean\tB-ORG\nUnion\tI-ORG\n's\tO\nscientific\tO\npanels\tO\n--\tO\nand\tO\nwe\tO\nhave\tO\nasked\tO\nthis\tO\nto\tO\nbe\tO\ndone\tO\nas\tO\nquickly\tO\nas\tO\npossible\tO\n--\tO\n(\tO\nconsumers\tO\n)\tO\nshould\tO\nif\tO\nat\tO\nall\tO\npossible\tO\ngive\tO\npreference\tO\nto\tO\nsheepmeat\tO\nfrom\tO\nother\tO\ncountries\tO\n,\tO\n\"\tO\nministry\tO\nofficial\tO\nWerner\tB-PER\nZwingmann\tI-PER\ntold\tO\nZDF\tB-ORG\ntelevision\tO\n.\tO\n\nBonn\tB-LOC\nhas\tO\nled\tO\nefforts\tO\nto\tO\nensure\tO\nconsumer\tO\nprotection\tO\ntops\tO\nthe\tO\nlist\tO\nof\tO\npriorities\tO\nin\tO\ndealing\tO\nwith\tO\nthe\tO\nmad\tO\ncow\tO\ncrisis\tO\n,\tO\nwhich\tO\nerupted\tO\nin\tO\nMarch\tO\nwhen\tO\nBritain\tB-LOC\nacknowledged\tO\nhumans\tO\ncould\tO\ncontract\tO\na\tO\nsimilar\tO\nillness\tO\nby\tO\neating\tO\ncontaminated\tO\nbeef\tO\n.\tO\n\nThe\tO\nEuropean\tB-ORG\nCommission\tI-ORG\nagreed\tO\nthis\tO\nmonth\tO\nto\tO\nrethink\tO\na\tO\nproposal\tO\nto\tO\nban\tO\nthe\tO\nuse\tO\nof\tO\nsuspect\tO\nsheep\tO\ntissue\tO\nafter\tO\nsome\tO\nEU\tB-ORG\nveterinary\tO\nexperts\tO\nquestioned\tO\nwhether\tO\nit\tO\nwas\tO\njustified\tO\n.\tO\n\nEU\tB-ORG\nFarm\tO\nCommissioner\tO\nFranz\tB-PER\nFischler\tI-PER\nhad\tO\nproposed\tO\nbanning\tO\nsheep\tO\nbrains\tO\n,\tO\nspleens\tO\nand\tO\nspinal\tO\ncords\tO\nfrom\tO\nthe\tO\nhuman\tO\nand\tO\nanimal\tO\nfood\tO\nchains\tO\nafter\tO\nreports\tO\nfrom\tO\nBritain\tB-LOC\nand\tO\nFrance\tB-LOC\nthat\tO\nunder\tO\nlaboratory\tO\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tO\n(\tO\nBSE\tB-MISC\n)\tO\n--\tO\nmad\tO\ncow\tO\ndisease\tO\n.\tO\n\nBut\tO\nsome\tO\nmembers\tO\nof\tO\nthe\tO\nEU\tB-ORG\n's\tO\nstanding\tO\nveterinary\tO\ncommittee\tO\nquestioned\tO\nwhether\tO\nthe\tO\naction\tO\nwas\tO\nnecessary\tO\ngiven\tO\nthe\tO\nslight\tO\nrisk\tO\nto\tO\nhuman\tO\nhealth\tO\n.\tO\n\nThe\tO\nquestion\tO\nis\tO\nbeing\tO\nstudied\tO\nseparately\tO\nby\tO\ntwo\tO\nEU\tB-ORG\nscientific\tO\ncommittees\tO\n.\tO\n\nSheep\tO\nhave\tO\nlong\tO\nbeen\tO\nknown\tO\nto\tO\ncontract\tO\nscrapie\tO\n,\tO\na\tO\nsimilar\tO\nbrain-wasting\tO\ndisease\tO\nto\tO\nBSE\tB-MISC\nwhich\tO\nis\tO\nbelieved\tO\nto\tO\nhave\tO\nbeen\tO\ntransferred\tO\nto\tO\ncattle\tO\nthrough\tO\nfeed\tO\ncontaining\tO\nanimal\tO\nwaste\tO\n.\tO\n\nZDF\tB-ORG\nsaid\tO\nGermany\tB-LOC\nimported\tO\n47,600\tO\nsheep\tO\nfrom\tO\nBritain\tB-LOC\nlast\tO\nyear\tO\n,\tO\nnearly\tO\nhalf\tO\nof\tO\ntotal\tO\nimports\tO\n.\tO\n\nAfter\tO\nthe\tO\nBritish\tB-MISC\ngovernment\tO\nadmitted\tO\na\tO\npossible\tO\nlink\tO\nbetween\tO\nmad\tO\ncow\tO\ndisease\tO\nand\tO\nits\tO\nfatal\tO\nhuman\tO\nequivalent\tO\n,\tO\nthe\tO\nEU\tB-ORG\nimposed\tO\na\tO\nworldwide\tO\nban\tO\non\tO\nBritish\tO\nbeef\tO\nexports\tO\n.\tO\n\nEU\tB-ORG\nleaders\tO\nagreed\tO\nat\tO\na\tO\nsummit\tO\nin\tO\nJune\tO\nto\tO\na\tO\nprogressive\tO\nlifting\tO\nof\tO\nthe\tO\nban\tO\nas\tO\nBritain\tB-LOC\ntakes\tO\nparallel\tO\nmeasures\tO\nto\tO\neradicate\tO\nthe\tO\ndisease\tO\n.\tO\n\nGOLF\tO\n-\tO\nSCORES\tO\nAT\tO\nWORLD\tB-MISC\nSERIES\tI-MISC\nOF\tI-MISC\nGOLF\tI-MISC\n.\tO\n\nAKRON\tO\n,\tO\nOhio\tB-LOC\n1996-08-22\tO\n\nmillion\tO\nNEC\tB-MISC\nWorld\tI-MISC\nSeries\tI-MISC\nof\tI-MISC\nGolf\tI-MISC\nafter\tO\nthe\tO\nfirst\tO\nround\tO\n\nThursday\tO\nat\tO\nthe\tO\n7,149\tO\nyard\tO\n,\tO\npar\tO\n70\tO\nFirestone\tB-LOC\nC.C\tI-LOC\ncourse\tO\n\n(\tO\nplayers\tO\nU.S.\tB-LOC\nunless\tO\nstated\tO\n)\tO\n:\tO\n\n66\tO\nPaul\tB-PER\nGoydos\tI-PER\n,\tO\nBilly\tB-PER\nMayfair\tI-PER\n,\tO\nHidemichi\tO\nTanaka\tO\n(\tO\nJapan\tB-LOC\n)\tO\n\n68\tO\nSteve\tB-PER\nStricker\tI-PER\n\n69\tO\nJustin\tO\nLeonard\tO\n,\tO\nMark\tB-PER\nBrooks\tI-PER\n\n70\tO\nTim\tO\nHerron\tO\n,\tO\nDuffy\tB-PER\nWaldorf\tI-PER\n,\tO\nDavis\tB-PER\nLove\tI-PER\n,\tO\nAnders\tB-PER\nForsbrand\tI-PER\n\n(\tO\nSweden\tO\n)\tO\n,\tO\nNick\tB-PER\nFaldo\tI-PER\n(\tO\nBritain\tO\n)\tO\n,\tO\nJohn\tO\nCook\tO\n,\tO\nSteve\tB-PER\nJones\tI-PER\n,\tO\nPhil\tO\n\nMickelson\tO\n,\tO\nGreg\tB-PER\nNorman\tI-PER\n(\tO\nAustralia\tO\n)\tO\n\n71\tO\nErnie\tB-PER\nEls\tI-PER\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\n,\tO\nScott\tO\nHoch\tO\n\n72\tO\nClarence\tB-PER\nRose\tI-PER\n,\tO\nLoren\tB-PER\nRoberts\tI-PER\n,\tO\nFred\tB-PER\nFunk\tI-PER\n,\tO\nSven\tB-PER\nStruver\tI-PER\n\n(\tO\nGermany\tB-LOC\n)\tO\n,\tO\nAlexander\tB-PER\nCejka\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\n,\tO\nHal\tB-PER\nSutton\tI-PER\n,\tO\nTom\tB-PER\nLehman\tI-PER\n\n73\tO\nD.A.\tB-PER\nWeibring\tI-PER\n,\tO\nBrad\tB-PER\nBryant\tI-PER\n,\tO\nCraig\tB-PER\nParry\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n,\tO\n\nStewart\tB-PER\nGinn\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n,\tO\nCorey\tB-PER\nPavin\tI-PER\n,\tO\nCraig\tB-PER\nStadler\tI-PER\n,\tO\nMark\tB-PER\n\nO'Meara\tB-PER\n,\tO\nFred\tO\nCouples\tO\n\n74\tO\nPaul\tB-PER\nStankowski\tI-PER\n,\tO\nCostantino\tB-PER\nRocca\tI-PER\n(\tO\nItaly\tB-LOC\n)\tO\n\n75\tO\nJim\tB-PER\nFuryk\tI-PER\n,\tO\nSatoshi\tB-PER\nHigashi\tI-PER\n(\tO\nJapan\tO\n)\tO\n,\tO\nWillie\tB-PER\nWood\tI-PER\n,\tO\nShigeki\tB-PER\n\nMaruyama\tO\n(\tO\nJapan\tB-LOC\n)\tO\n\n76\tO\nScott\tB-PER\nMcCarron\tI-PER\n\n77\tO\nWayne\tB-PER\nWestner\tI-PER\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\n,\tO\nSteve\tB-PER\nSchneiter\tI-PER\n\n79\tO\nTom\tB-PER\nWatson\tI-PER\n\n81\tO\nSeiki\tB-PER\nOkuda\tI-PER\n(\tO\nJapan\tB-LOC\n)\tO\n\nSOCCER\tO\n-\tO\nGLORIA\tB-ORG\nBISTRITA\tI-ORG\nBEAT\tO\n2-1\tO\nF.C.\tB-ORG\nVALLETTA\tI-ORG\n.\tO\n\nGloria\tB-ORG\nBistrita\tI-ORG\n(\tO\nRomania\tB-LOC\n)\tO\nbeat\tO\n2-1\tO\n(\tO\nhalftime\tO\n1-1\tO\n)\tO\nF.C.\tB-ORG\nValletta\tI-ORG\n(\tO\nMalta\tB-LOC\n)\tO\nin\tO\ntheir\tO\nCup\tB-MISC\nwinners\tI-MISC\nCup\tI-MISC\nmatch\tO\n,\tO\nsecond\tO\nleg\tO\nof\tO\nthe\tO\npreliminary\tO\nround\tO\n,\tO\non\tO\nThursday\tO\n.\tO\n\nGloria\tB-ORG\nBistrita\tI-ORG\n-\tO\nIlie\tB-PER\nLazar\tI-PER\n(\tO\n32nd\tO\n)\tO\n,\tO\nEugen\tB-PER\nVoica\tI-PER\n(\tO\n84th\tO\n)\tO\n\nF.C.\tO\nLa\tO\nValletta\tO\n-\tO\nGilbert\tB-PER\nAgius\tI-PER\n(\tO\n24th\tO\n)\tO\n\nGloria\tB-ORG\nBistrita\tI-ORG\nwon\tO\n4-2\tO\non\tO\naggregate\tO\nand\tO\nqualified\tO\nfor\tO\nthe\tO\nfirst\tO\nround\tO\nof\tO\nthe\tO\nCup\tB-MISC\nwinners\tI-MISC\nCup\tI-MISC\n.\tO\n\nHORSE\tO\nRACING\tO\n-\tO\nPIVOTAL\tB-PER\nENDS\tO\n25-YEAR\tO\nWAIT\tO\nFOR\tO\nTRAINER\tO\nPRESCOTT\tB-PER\n.\tO\n\nYORK\tB-LOC\n,\tO\nEngland\tB-LOC\n1996-08-22\tO\n\nSir\tO\nMark\tB-PER\nPrescott\tI-PER\nlanded\tO\nhis\tO\nfirst\tO\ngroup\tO\none\tO\nvictory\tO\nin\tO\n25\tO\nyears\tO\nas\tO\na\tO\ntrainer\tO\nwhen\tO\nhis\tO\ntop\tO\nsprinter\tO\nPivotal\tB-PER\n,\tO\na\tO\n100-30\tO\nchance\tO\n,\tO\nwon\tO\nthe\tO\nNunthorpe\tB-MISC\nStakes\tI-MISC\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nthree-year-old\tO\n,\tO\npartnered\tO\nby\tO\nveteran\tO\nGeorge\tB-PER\nDuffield\tI-PER\n,\tO\nsnatched\tO\na\tO\nshort\tO\nhead\tO\nverdict\tO\nin\tO\nthe\tO\nlast\tO\nstride\tO\nto\tO\ndeny\tO\nEveningperformance\tB-PER\n(\tO\n16-1\tO\n)\tO\n,\tO\ntrained\tO\nby\tO\nHenry\tB-PER\nCandy\tI-PER\nand\tO\nridden\tO\nby\tO\nChris\tB-PER\nRutter\tI-PER\n.\tO\n\nHever\tB-PER\nGolf\tI-PER\nRose\tI-PER\n(\tO\n11-4\tO\n)\tO\n,\tO\nlast\tO\nyear\tO\n's\tO\nPrix\tB-MISC\nde\tI-MISC\nl\tI-MISC\n'\tI-MISC\nAbbaye\tI-MISC\nwinner\tO\nat\tO\nLongchamp\tB-LOC\n,\tO\nfinished\tO\nthird\tO\n,\tO\na\tO\nfurther\tO\none\tO\nand\tO\na\tO\nquarter\tO\nlengths\tO\naway\tO\nwith\tO\nthe\tO\n7-4\tO\nfavourite\tO\nMind\tB-PER\nGames\tI-PER\nin\tO\nfourth\tO\n.\tO\n\nPivotal\tB-PER\n,\tO\na\tO\nRoyal\tB-PER\nAscot\tI-PER\nwinner\tO\nin\tO\nJune\tO\n,\tO\nmay\tO\nnow\tO\nbe\tO\naimed\tO\nat\tO\nthis\tO\nseason\tO\n's\tO\nAbbaye\tB-MISC\n,\tO\nEurope\tB-LOC\n's\tO\ntop\tO\nsprint\tO\nrace\tO\n.\tO\n\nPrescott\tB-PER\n,\tO\nreluctant\tO\nto\tO\ngo\tO\ninto\tO\nthe\tO\nwinner\tO\n's\tO\nenclosure\tO\nuntil\tO\nthe\tO\nresult\tO\nof\tO\nthe\tO\nphoto-finish\tO\nwas\tO\nannounced\tO\n,\tO\nsaid\tO\n:\tO\n\"\tO\nTwenty-five\tO\nyears\tO\nand\tO\nI\tO\nhave\tO\nnever\tO\nbeen\tO\nthere\tO\nso\tO\nI\tO\nthought\tO\nI\tO\nhad\tO\nbetter\tO\nwait\tO\na\tO\nbit\tO\nlonger\tO\n.\tO\n\"\tO\n\nHe\tO\nadded\tO\n:\tO\n\"\tO\nIt\tO\n's\tO\nvery\tO\nsad\tO\nto\tO\nbeat\tO\nHenry\tB-PER\nCandy\tI-PER\nbecause\tO\nI\tO\nam\tO\ngodfather\tO\nto\tO\nhis\tO\ndaughter\tO\n.\tO\n\"\tO\n\nLike\tO\nPrescott\tB-PER\n,\tO\nJack\tB-PER\nBerry\tI-PER\n,\tO\ntrainer\tO\nof\tO\nMind\tB-PER\nGames\tI-PER\n,\tO\nhad\tO\ngone\tO\ninto\tO\nThursday\tO\n's\tO\nrace\tO\nin\tO\nsearch\tO\nof\tO\na\tO\nfirst\tO\ngroup\tO\none\tO\nsuccess\tO\nafter\tO\nmany\tO\nyears\tO\naround\tO\nthe\tO\ntop\tO\nof\tO\nhis\tO\nprofession\tO\n.\tO\n\nBerry\tB-PER\nsaid\tO\n:\tO\n\"\tO\nI`m\tO\ndisappointed\tO\nbut\tO\nI\tO\ndo\tO\nn't\tO\nfeel\tO\nsuicidal\tO\n.\tO\n\nHe\tO\n(\tO\nMind\tB-PER\nGames\tI-PER\n)\tO\nwas\tO\ngoing\tO\nas\tO\nwell\tO\nas\tO\nany\tO\nof\tO\nthem\tO\none\tO\nand\tO\na\tO\nhalf\tO\nfurlongs\tO\n(\tO\n300\tO\nmetres\tO\n)\tO\nout\tO\nbut\tO\nhe\tO\njust\tO\ndid\tO\nn't\tO\nquicken\tO\n.\tO\n\"\tO\n\nResult\tO\nof\tO\nthe\tO\nNunthorpe\tB-MISC\nStakes\tI-MISC\n,\tO\na\tO\ngroup\tO\none\tO\nrace\tO\nfor\tO\ntwo-year-olds\tO\nand\tO\nupwards\tO\n,\tO\nrun\tO\nover\tO\nfive\tO\nfurlongs\tO\n(\tO\n1\tO\nkm\tO\n)\tO\non\tO\nThursday\tO\n:\tO\n\n2.\tO\nEveningperformance\tB-PER\n16-1\tO\n(\tO\nChris\tB-PER\nRutter\tI-PER\n)\tO\n\n3.\tO\nHever\tB-PER\nGolf\tI-PER\nRose\tI-PER\n11-4\tO\n(\tO\nJason\tO\nWeaver\tO\n)\tO\n\nFavourite\tO\n:\tO\nMind\tB-PER\nGames\tI-PER\n(\tO\n7-4\tO\n)\tO\nfinished\tO\n4th\tO\n\nWinner\tO\nowned\tO\nby\tO\nthe\tO\nCheveley\tB-ORG\nPark\tI-ORG\nStud\tI-ORG\nand\tO\ntrained\tO\nby\tO\nSir\tO\n\nMark\tB-PER\nPrescott\tI-PER\nat\tO\nNewmarket\tB-LOC\n.\tO\n\nTENNIS\tO\n-\tO\nRESULTS\tO\nAT\tO\nTOSHIBA\tB-MISC\nCLASSIC\tI-MISC\n.\tO\n\nCARLSBAD\tB-LOC\n,\tO\nCalifornia\tB-LOC\n1996-08-21\tO\n\n$\tO\n450,000\tO\nToshiba\tB-MISC\nClassic\tI-MISC\ntennis\tO\ntournament\tO\non\tO\nWednesday\tO\n\n1\tO\n-\tO\nArantxa\tB-PER\nSanchez\tI-PER\nVicario\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\nbeat\tO\nNaoko\tB-PER\nKijimuta\tI-PER\n(\tO\nJapan\tO\n)\tO\n\n4\tO\n-\tO\nKimiko\tB-PER\nDate\tI-PER\n(\tO\nJapan\tB-LOC\n)\tO\nbeat\tO\nYone\tB-PER\nKamio\tI-PER\n(\tO\nJapan\tB-LOC\n)\tO\n6-2\tO\n7-5\tO\n\nSandrine\tB-PER\nTestud\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\nbeat\tO\n7\tO\n-\tO\nAi\tB-PER\nSugiyama\tI-PER\n(\tO\nJapan\tB-LOC\n)\tO\n6-3\tO\n4-6\tO\n\n8\tO\n-\tO\nNathalie\tB-PER\nTauziat\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\nbeat\tO\nShi-Ting\tB-PER\nWang\tI-PER\n(\tO\nTaiwan\tB-LOC\n)\tO\n6-4\tO\n\nTENNIS\tO\n-\tO\nRESULTS\tO\nAT\tO\nHAMLET\tB-MISC\nCUP\tI-MISC\n.\tO\n\nCOMMACK\tB-LOC\n,\tO\nNew\tB-LOC\nYork\tI-LOC\n1996-08-21\tO\n\nWaldbaum\tB-MISC\nHamlet\tI-MISC\nCup\tI-MISC\ntennis\tO\ntournament\tO\non\tO\nWednesday\tO\n(\tO\nprefix\tO\n\n1\tO\n-\tO\nMichael\tB-PER\nChang\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tO\nSergi\tB-PER\nBruguera\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n6-3\tO\n6-2\tO\n\nMichael\tB-PER\nJoyce\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tO\n3\tO\n-\tO\nRichey\tB-PER\nReneberg\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n3-6\tO\n6-4\tO\n\nMartin\tB-PER\nDamm\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nbeat\tO\n6\tO\n-\tO\nYounes\tB-PER\nEl\tI-PER\nAynaoui\tI-PER\n\nKarol\tB-PER\nKucera\tI-PER\n(\tO\nSlovakia\tB-LOC\n)\tO\nbeat\tO\nHicham\tB-PER\nArazi\tI-PER\n(\tO\nMorocco\tB-LOC\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n\nSOCCER\tO\n-\tO\nDALGLISH\tB-PER\nSAD\tO\nOVER\tO\nBLACKBURN\tB-ORG\nPARTING\tO\n.\tO\n\nKenny\tB-PER\nDalglish\tI-PER\nspoke\tO\non\tO\nThursday\tO\nof\tO\nhis\tO\nsadness\tO\nat\tO\nleaving\tO\nBlackburn\tB-ORG\n,\tO\nthe\tO\nclub\tO\nhe\tO\nled\tO\nto\tO\nthe\tO\nEnglish\tB-MISC\npremier\tO\nleague\tO\ntitle\tO\nin\tO\n1994-95\tO\n.\tO\n\nBlackburn\tB-ORG\nannounced\tO\non\tO\nWednesday\tO\nthey\tO\nand\tO\nDalglish\tB-PER\nhad\tO\nparted\tO\nby\tO\nmutual\tO\nconsent\tO\n.\tO\n\nBut\tO\nthe\tO\nex-manager\tO\nconfessed\tO\non\tO\nThursday\tO\nto\tO\nbeing\tO\n\"\tO\nsad\tO\n\"\tO\nat\tO\nleaving\tO\nafter\tO\ntaking\tO\nBlackburn\tB-ORG\nfrom\tO\nthe\tO\nsecond\tO\ndivision\tO\nto\tO\nthe\tO\npremier\tO\nleague\tO\ntitle\tO\ninside\tO\nthree\tO\nand\tO\na\tO\nhalf\tO\nyears\tO\n.\tO\n\nIn\tO\na\tO\ntelephone\tO\ncall\tO\nto\tO\na\tO\nlocal\tO\nnewspaper\tO\nfrom\tO\nhis\tO\nholiday\tO\nhome\tO\nin\tO\nSpain\tB-LOC\n,\tO\nDalglish\tB-PER\nsaid\tO\n:\tO\n\"\tO\nWe\tO\ncame\tO\nto\tO\nthe\tO\nsame\tO\nopinion\tO\n,\tO\nalbeit\tO\nthe\tO\nclub\tO\ncame\tO\nto\tO\nit\tO\na\tO\nlittle\tO\nbit\tO\nearlier\tO\nthan\tO\nme\tO\n.\tO\n\"\tO\n\nDalglish\tB-PER\nhad\tO\nbeen\tO\nwith\tO\nBlackburn\tB-ORG\nfor\tO\nnearly\tO\nfive\tO\nyears\tO\n,\tO\nfirst\tO\nas\tO\nmanager\tO\nand\tO\nthen\tO\n,\tO\nfor\tO\nthe\tO\npast\tO\n15\tO\nmonths\tO\n,\tO\nas\tO\ndirector\tO\nof\tO\nfootball\tO\n.\tO\n\nCRICKET\tO\n-\tO\nENGLISH\tB-MISC\nCOUNTY\tI-MISC\nCHAMPIONSHIP\tI-MISC\nSCORES\tO\n.\tO\n\nEnglish\tB-MISC\nCounty\tO\nChampionship\tO\ncricket\tO\nmatches\tO\non\tO\nThursday\tO\n:\tO\n\nAt\tO\nWeston-super-Mare\tB-LOC\n:\tO\nDurham\tO\n326\tO\n(\tO\nD.\tB-PER\nCox\tI-PER\n95\tO\nnot\tO\nout\tO\n,\tO\n\nS.\tB-PER\nCampbell\tI-PER\n69\tO\n;\tO\nG.\tB-PER\nRose\tI-PER\n7-73\tO\n)\tO\n.\tO\n\nSomerset\tO\n236-4\tO\n(\tO\nM.\tB-PER\nLathwell\tI-PER\n85\tO\n)\tO\n.\tO\n\nAt\tO\nColchester\tB-LOC\n:\tO\nGloucestershire\tB-ORG\n280\tO\n(\tO\nJ.\tB-PER\nRussell\tI-PER\n63\tO\n,\tO\nA.\tB-PER\nSymonds\tI-PER\n\nEssex\tB-ORG\n72-0\tO\n.\tO\n\nAt\tO\nCardiff\tB-LOC\n:\tO\nKent\tB-ORG\n128-1\tO\n(\tO\nM.\tB-PER\nWalker\tI-PER\n59\tO\n,\tO\nD.\tB-PER\nFulton\tI-PER\n53\tO\nnot\tO\nout\tO\n)\tO\nv\tO\n\nGlamorgan\tB-ORG\n.\tO\n\nAt\tO\nLeicester\tB-LOC\n:\tO\nLeicestershire\tB-ORG\n343-8\tO\n(\tO\nP.\tO\nSimmons\tO\n108\tO\n,\tO\nP.\tB-PER\nNixon\tI-PER\n\nAt\tO\nNorthampton\tB-LOC\n:\tO\nSussex\tB-ORG\n368-7\tO\n(\tO\nN.\tB-PER\nLenham\tI-PER\n145\tO\n,\tO\nV.\tB-PER\nDrakes\tI-PER\n59\tO\nnot\tO\n\nout\tO\n,\tO\nA.\tB-PER\nWells\tI-PER\n51\tO\n)\tO\nv\tO\nNorthamptonshire\tB-ORG\n.\tO\n\nAt\tO\nTrent\tB-LOC\nBridge\tI-LOC\n:\tO\nNottinghamshire\tB-ORG\n392-6\tO\n(\tO\nG.\tB-PER\nArcher\tI-PER\n143\tO\nnot\tO\n\nout\tO\n,\tO\nM.\tB-PER\nDowman\tI-PER\n107\tO\n)\tO\nv\tO\nSurrey\tB-ORG\n.\tO\n\nAt\tO\nWorcester\tB-LOC\n:\tO\nWarwickshire\tO\n255-9\tO\n(\tO\nA.\tB-PER\nGiles\tI-PER\n57\tO\nnot\tO\nout\tO\n,\tO\nW.\tB-PER\nKhan\tI-PER\n\n52\tO\n)\tO\nv\tO\nWorcestershire\tB-ORG\n.\tO\n\nAt\tO\nHeadingley\tB-LOC\n:\tO\nYorkshire\tB-ORG\n305-5\tO\n(\tO\nC.\tB-PER\nWhite\tI-PER\n66\tO\nnot\tO\nout\tO\n,\tO\nM.\tO\nMoxon\tO\n\n66\tO\n,\tO\nM.\tB-PER\nVaughan\tI-PER\n57\tO\n)\tO\nv\tO\nLancashire\tO\n.\tO\n\nCRICKET\tO\n-\tO\nENGLAND\tB-LOC\nV\tO\nPAKISTAN\tB-LOC\nFINAL\tO\nTEST\tO\nSCOREBOARD\tO\n.\tO\n\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nbetween\tO\nEngland\tB-LOC\nand\tO\nPakistan\tB-LOC\nat\tO\nThe\tB-LOC\nOval\tI-LOC\non\tO\n\nEngland\tB-LOC\nfirst\tO\ninnings\tO\n\nM.\tB-PER\nAtherton\tI-PER\nb\tO\nWaqar\tB-PER\nYounis\tI-PER\n31\tO\n\nA.\tB-PER\nStewart\tI-PER\nb\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n44\tO\n\nN.\tB-PER\nHussain\tI-PER\nc\tO\nSaeed\tB-PER\nAnwar\tI-PER\nb\tO\nWaqar\tB-PER\nYounis\tI-PER\n12\tO\n\nG.\tB-PER\nThorpe\tI-PER\nlbw\tO\nb\tO\nMohammad\tB-PER\nAkram\tI-PER\n54\tO\n\nJ.\tB-PER\nCrawley\tI-PER\nnot\tO\nout\tO\n94\tO\n\nN.\tB-PER\nKnight\tI-PER\nb\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n17\tO\n\nC.\tB-PER\nLewis\tI-PER\nb\tO\nWasim\tB-PER\nAkram\tI-PER\n5\tO\n\nTo\tO\nbat\tO\n:\tO\nR.\tB-PER\nCroft\tI-PER\n,\tO\nD.\tB-PER\nCork\tI-PER\n,\tO\nA.\tO\nMullally\tO\n\nBowling\tO\n(\tO\nto\tO\ndate\tO\n)\tO\n:\tO\nWasim\tB-PER\nAkram\tI-PER\n25-8-61-1\tO\n,\tO\nWaqar\tO\nYounis\tO\n\n20-6-70-2\tO\n,\tO\nMohammad\tB-PER\nAkram\tI-PER\n12-1-41-1\tO\n,\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n27-5-78-2\tO\n,\tO\n\nPakistan\tB-LOC\n:\tO\nAamir\tB-PER\nSohail\tI-PER\n,\tO\nSaeed\tB-PER\nAnwar\tI-PER\n,\tO\nIjaz\tB-PER\nAhmed\tI-PER\n,\tO\n\nInzamam-ul-Haq\tO\n,\tO\nSalim\tB-PER\nMalik\tI-PER\n,\tO\nAsif\tB-PER\nMujtaba\tI-PER\n,\tO\nWasim\tB-PER\nAkram\tI-PER\n,\tO\nMoin\tB-PER\n\nKhan\tO\n,\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n,\tO\nWaqar\tB-PER\nYounis\tI-PER\n,\tO\nMohammad\tO\nAkam\tO\n\nSOCCER\tO\n-\tO\nFERGUSON\tB-PER\nBACK\tO\nIN\tO\nSCOTTISH\tB-MISC\nSQUAD\tO\nAFTER\tO\n20\tO\nMONTHS\tO\n.\tO\n\nEverton\tB-ORG\n's\tO\nDuncan\tB-PER\nFerguson\tI-PER\n,\tO\nwho\tO\nscored\tO\ntwice\tO\nagainst\tO\nManchester\tB-ORG\nUnited\tI-ORG\non\tO\nWednesday\tO\n,\tO\nwas\tO\npicked\tO\non\tO\nThursday\tO\nfor\tO\nthe\tO\nScottish\tB-MISC\nsquad\tO\nafter\tO\na\tO\n20-month\tO\nexile\tO\n.\tO\n\nGlasgow\tB-ORG\nRangers\tI-ORG\nstriker\tO\nAlly\tB-PER\nMcCoist\tI-PER\n,\tO\nanother\tO\nman\tO\nin\tO\nform\tO\nafter\tO\ntwo\tO\nhat-tricks\tO\nin\tO\nfour\tO\ndays\tO\n,\tO\nwas\tO\nalso\tO\nnamed\tO\nfor\tO\nthe\tO\nAugust\tO\n31\tO\nWorld\tB-MISC\nCup\tI-MISC\nqualifier\tO\nagainst\tO\nAustria\tB-LOC\nin\tO\nVienna\tB-LOC\n.\tO\n\nFerguson\tB-PER\n,\tO\nwho\tO\nserved\tO\nsix\tO\nweeks\tO\nin\tO\njail\tO\nin\tO\nlate\tO\n1995\tO\nfor\tO\nhead-butting\tO\nan\tO\nopponent\tO\n,\tO\nwon\tO\nthe\tO\nlast\tO\nof\tO\nhis\tO\nfive\tO\nScotland\tB-LOC\ncaps\tO\nin\tO\nDecember\tO\n1994\tO\n.\tO\n\nScotland\tB-LOC\nmanager\tO\nCraig\tB-PER\nBrown\tI-PER\nsaid\tO\non\tO\nThursday\tO\n:\tO\n\"\tO\nI\tO\n've\tO\nwatched\tO\nDuncan\tB-PER\nFerguson\tI-PER\nin\tO\naction\tO\ntwice\tO\nrecently\tO\nand\tO\nhe\tO\n's\tO\nbang\tO\nin\tO\nform\tO\n.\tO\n\nAlly\tB-PER\nMcCoist\tI-PER\nis\tO\nalso\tO\nin\tO\ngreat\tO\nscoring\tO\nform\tO\nat\tO\nthe\tO\nmoment\tO\n.\tO\n\"\tO\n\nCeltic\tB-ORG\n's\tO\nJackie\tB-PER\nMcNamara\tI-PER\n,\tO\nwho\tO\ndid\tO\nwell\tO\nwith\tO\nlast\tO\nseason\tO\n's\tO\nsuccessful\tO\nunder-21\tO\nteam\tO\n,\tO\nearns\tO\na\tO\ncall-up\tO\nto\tO\nthe\tO\nsenior\tO\nsquad\tO\n.\tO\n\nCRICKET\tO\n-\tO\nENGLAND\tB-LOC\n100-2\tO\nAT\tO\nLUNCH\tO\nON\tO\nFIRST\tO\nDAY\tO\nOF\tO\nTHIRD\tO\nTEST\tO\n.\tO\n\nEngland\tB-LOC\nwere\tO\n100\tO\nfor\tO\ntwo\tO\nat\tO\nlunch\tO\non\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\nthe\tO\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nagainst\tO\nPakistan\tB-LOC\nat\tO\nThe\tB-LOC\nOval\tI-LOC\non\tO\nThursday\tO\n.\tO\n\nSOCCER\tO\n-\tO\nKEANE\tB-PER\nSIGNS\tO\nFOUR-YEAR\tO\nCONTRACT\tO\nWITH\tO\nMANCHESTER\tB-LOC\nUNITED\tI-LOC\n.\tO\n\nIreland\tB-LOC\nmidfielder\tO\nRoy\tB-PER\nKeane\tI-PER\nhas\tO\nsigned\tO\na\tO\nnew\tO\nfour-year\tO\ncontract\tO\nwith\tO\nEnglish\tB-MISC\nleague\tO\nand\tO\nF.A.\tB-MISC\nCup\tI-MISC\nchampions\tO\nManchester\tB-ORG\nUnited\tI-ORG\n.\tO\n\n\"\tO\nRoy\tB-PER\nagreed\tO\na\tO\nnew\tO\ndeal\tO\nbefore\tO\nlast\tO\nnight\tO\n's\tO\ngame\tO\nagainst\tO\nEverton\tB-ORG\nand\tO\nwe\tO\nare\tO\ndelighted\tO\n,\tO\n\"\tO\nsaid\tO\nUnited\tB-ORG\nmanager\tO\nAlex\tB-PER\nFerguson\tI-PER\non\tO\nThursday\tO\n.\tO\n\nTENNIS\tO\n-\tO\nRESULTS\tO\nAT\tO\nCANADIAN\tB-MISC\nOPEN\tI-MISC\n.\tO\n\nResults\tO\nfrom\tO\nthe\tO\nCanadian\tB-MISC\nOpen\tI-MISC\n\nDaniel\tB-PER\nNestor\tI-PER\n(\tO\nCanada\tO\n)\tO\nbeat\tO\n1\tO\n-\tO\nThomas\tB-PER\nMuster\tI-PER\n(\tO\nAustria\tB-LOC\n)\tO\n6-3\tO\n7-5\tO\n\nMikael\tB-PER\nTillstrom\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\nbeat\tO\n2\tO\n-\tO\nGoran\tB-PER\nIvanisevic\tI-PER\n(\tO\nCroatia\tB-LOC\n)\tO\n\n3\tO\n-\tO\nWayne\tB-PER\nFerreira\tI-PER\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\nbeat\tO\nJiri\tB-PER\nNovak\tI-PER\n(\tO\nCzech\tB-LOC\n\nRepublic\tB-LOC\n)\tO\n7-5\tO\n6-3\tO\n\n4\tO\n-\tO\nMarcelo\tB-PER\nRios\tI-PER\n(\tO\nChile\tB-LOC\n)\tO\nbeat\tO\nKenneth\tB-PER\nCarlsen\tI-PER\n(\tO\nDenmark\tB-LOC\n)\tO\n6-3\tO\n6-2\tO\n\n6\tO\n-\tO\nMaliVai\tO\nWashington\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tO\nAlex\tB-PER\nCorretja\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n6-4\tO\n\n7\tO\n-\tO\nTodd\tB-PER\nMartin\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tO\nRenzo\tO\nFurlan\tO\n(\tO\nItaly\tB-LOC\n)\tO\n7-6\tO\n(\tO\n7-3\tO\n)\tO\n6-3\tO\n\nMark\tO\nPhilippoussis\tO\n(\tO\nAustralia\tO\n)\tO\nbeat\tO\n8\tO\n-\tO\nMarc\tB-PER\nRosset\tI-PER\n\n9\tO\n-\tO\nCedric\tB-PER\nPioline\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\nbeat\tO\nGregory\tB-PER\nCarraz\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\n7-6\tO\n\nPatrick\tB-PER\nRafter\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\nbeat\tO\n11\tO\n-\tO\nAlberto\tB-PER\nBerasategui\tI-PER\n\n(\tO\nSpain\tB-LOC\n)\tO\n6-1\tO\n6-2\tO\n\nPetr\tB-PER\nKorda\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nbeat\tO\n12\tO\n-\tO\nFrancisco\tO\nClavet\tO\n(\tO\nSpain\tB-LOC\n)\tO\n\nDaniel\tB-PER\nVacek\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nbeat\tO\n13\tO\n-\tO\nJason\tB-PER\nStoltenberg\tI-PER\n\n(\tO\nAustralia\tB-LOC\n)\tO\n5-7\tO\n7-6\tO\n(\tO\n7-1\tO\n)\tO\n7-6\tO\n(\tO\n13-11\tO\n)\tO\n\nTodd\tB-PER\nWoodbridge\tI-PER\n(\tO\nAustralia\tB-LOC\nbeat\tO\nSebastien\tB-PER\nLareau\tI-PER\n(\tO\nCanada\tB-LOC\n)\tO\n6-3\tO\n\nAlex\tO\nO'Brien\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tO\nByron\tB-PER\nBlack\tI-PER\n(\tO\nZimbabwe\tB-LOC\n)\tO\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n6-2\tO\n\nBohdan\tB-PER\nUlihrach\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nbeat\tO\nAndrea\tB-PER\nGaudenzi\tI-PER\n(\tO\nItaly\tB-LOC\n)\tO\n\nTim\tB-PER\nHenman\tI-PER\n(\tO\nBritain\tB-LOC\n)\tO\nbeat\tO\nChris\tB-PER\nWoodruff\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n,\tO\nwalkover\tO\n\nCRICKET\tO\n-\tO\nMILLNS\tB-PER\nSIGNS\tO\nFOR\tO\nBOLAND\tB-ORG\n.\tO\n\nSouth\tB-MISC\nAfrican\tI-MISC\nprovincial\tO\nside\tO\nBoland\tB-ORG\nsaid\tO\non\tO\nThursday\tO\nthey\tO\nhad\tO\nsigned\tO\nLeicestershire\tB-ORG\nfast\tO\nbowler\tO\nDavid\tB-PER\nMillns\tI-PER\non\tO\na\tO\none\tO\nyear\tO\ncontract\tO\n.\tO\n\nMillns\tB-MISC\n,\tO\nwho\tO\ntoured\tO\nAustralia\tB-LOC\nwith\tO\nEngland\tB-LOC\nA\tO\nin\tO\n1992/93\tO\n,\tO\nreplaces\tO\nformer\tO\nEngland\tB-LOC\nall-rounder\tO\nPhillip\tB-PER\nDeFreitas\tI-PER\nas\tO\nBoland\tB-ORG\n's\tO\noverseas\tO\nprofessional\tO\n.\tO\n\nSOCCER\tO\n-\tO\nEUROPEAN\tB-MISC\nCUP\tI-MISC\nWINNERS\tI-MISC\n'\tI-MISC\nCUP\tI-MISC\nRESULTS\tO\n.\tO\n\nResults\tO\nof\tO\nEuropean\tB-MISC\nCup\tI-MISC\nWinners\tI-MISC\n'\tI-MISC\n\nCup\tB-MISC\nqualifying\tO\nround\tO\n,\tO\nsecond\tO\nleg\tO\nsoccer\tO\nmatches\tO\non\tO\nThursday\tO\n:\tO\n\nIn\tO\nTirana\tB-LOC\n:\tO\nFlamurtari\tB-ORG\nVlore\tI-ORG\n(\tO\nAlbania\tB-LOC\n)\tO\n0\tO\nChemlon\tB-ORG\nHumenne\tI-ORG\n\n(\tO\nSlovakia\tB-LOC\n)\tO\n2\tO\n(\tO\nhalftime\tO\n0-0\tO\n)\tO\n\nScorers\tO\n:\tO\nLubarskij\tB-PER\n(\tO\n50th\tO\nminute\tO\n)\tO\n,\tO\nValkucak\tB-PER\n(\tO\n54th\tO\n)\tO\n\nChemlon\tB-ORG\nHumenne\tI-ORG\nwin\tO\n3-0\tO\non\tO\naggregate\tO\n\nIn\tO\nBistrita\tB-LOC\n:\tO\nGloria\tB-ORG\nBistrita\tI-ORG\n(\tO\nRomania\tB-LOC\n)\tO\n2\tO\nValletta\tB-LOC\n(\tO\nMalta\tB-LOC\n)\tO\n1\tO\n\nValletta\tO\n-\tO\nGilbert\tB-PER\nAgius\tI-PER\n(\tO\n24th\tO\n)\tO\n\nGloria\tB-ORG\nBistrita\tI-ORG\nwin\tO\n4-2\tO\non\tO\naggregate\tO\n.\tO\n\nIn\tO\nChorzow\tO\n:\tO\nRuch\tB-ORG\nChorzow\tI-ORG\n(\tO\nPoland\tB-LOC\n)\tO\n5\tO\nLlansantffraid\tB-ORG\n(\tO\nWales\tB-LOC\n)\tO\n0\tO\n\nScorers\tO\n:\tO\nArkadiusz\tB-PER\nBak\tI-PER\n(\tO\n1st\tO\nand\tO\n55th\tO\n)\tO\n,\tO\nArwel\tO\nJones\tO\n(\tO\n47th\tO\n,\tO\n\nown\tO\ngoal\tO\n)\tO\n,\tO\nMiroslav\tB-PER\nBak\tI-PER\n(\tO\n62nd\tO\nand\tO\n63rd\tO\n)\tO\n\nIn\tO\nLarnaca\tB-LOC\n:\tO\nAEK\tB-ORG\nLarnaca\tI-ORG\n(\tO\nCyprus\tB-LOC\n)\tO\n5\tO\nKotaik\tO\nAbovyan\tO\n(\tO\nArmenia\tB-LOC\n)\tO\n\nScorers\tO\n:\tO\nZoran\tB-PER\nKundic\tI-PER\n(\tO\n28th\tO\n)\tO\n,\tO\nKlimis\tB-PER\nAlexandrou\tI-PER\n(\tO\n41st\tO\n)\tO\n,\tO\n\nMilenko\tB-PER\nKovasevic\tI-PER\n(\tO\n60th\tO\n,\tO\npenalty\tO\n)\tO\n,\tO\nGoran\tO\nKoprinovic\tO\n(\tO\n82nd\tO\n)\tO\n,\tO\n\nPavlos\tB-PER\nMarkou\tI-PER\n(\tO\n84th\tO\n)\tO\n\nAEK\tB-ORG\nLarnaca\tI-ORG\nwin\tO\n5-1\tO\non\tO\naggregate\tO\n\nIn\tO\nSiauliai\tB-LOC\n:\tO\nKareda\tB-ORG\nSiauliai\tI-ORG\n(\tO\nLithuania\tO\n)\tO\n0\tO\nSion\tB-ORG\n\nSion\tB-ORG\nwin\tO\n4-2\tO\non\tO\nagrregate\tO\n.\tO\n\nNyva\tB-ORG\nVinnytsya\tI-ORG\n(\tO\nUkraine\tB-LOC\n)\tO\n1\tO\nTallinna\tB-ORG\nSadam\tI-ORG\n(\tO\nEstonia\tO\n)\tO\n0\tO\n(\tO\n0-0\tO\n)\tO\n\nIn\tO\nBergen\tB-LOC\n:\tO\nBrann\tB-ORG\n(\tO\nNorway\tB-LOC\n)\tO\n2\tO\nShelbourne\tB-ORG\n(\tO\nIreland\tB-LOC\n)\tO\n1\tO\n(\tO\n1-1\tO\n)\tO\n\nBrann\tB-ORG\n-\tO\nMons\tB-PER\nIvar\tI-PER\nMjelde\tI-PER\n(\tO\n10th\tO\n)\tO\n,\tO\nJan\tB-PER\nOve\tI-PER\nPedersen\tI-PER\n(\tO\n72nd\tO\n)\tO\n\nShelbourne\tB-ORG\n-\tO\nMark\tO\nRutherford\tO\n(\tO\n5th\tO\n)\tO\n\nBrann\tB-ORG\nwin\tO\n5-2\tO\non\tO\naggregate\tO\n\nIn\tO\nSofia\tB-LOC\n:\tO\nLevski\tB-ORG\nSofia\tI-ORG\n(\tO\nBulgaria\tB-LOC\n)\tO\n1\tO\nOlimpija\tB-ORG\n(\tO\nSlovenia\tB-LOC\n)\tO\n0\tO\n\nOlimpija\tB-ORG\nwon\tO\n4-3\tO\non\tO\npenalties\tO\n.\tO\n\nIn\tO\nVaduz\tB-LOC\n:\tO\nVaduz\tB-LOC\n(\tO\nLiechtenstein\tB-LOC\n)\tO\n1\tO\nRAF\tB-ORG\nRiga\tI-ORG\n(\tO\nLatvia\tB-LOC\n)\tO\n1\tO\n(\tO\n0-0\tO\n)\tO\n\nVaduz\tB-LOC\n-\tO\nDaniele\tB-PER\nPolverino\tI-PER\n(\tO\n90th\tO\n)\tO\n\nRAF\tB-ORG\nRiga\tI-ORG\n-\tO\nAgrins\tB-PER\nZarins\tI-PER\n(\tO\n47th\tO\n)\tO\n\nVaduz\tB-LOC\nwon\tO\n4-2\tO\non\tO\npenalties\tO\n.\tO\n\nIn\tO\nLuxembourg\tB-LOC\n:\tO\nUS\tB-ORG\nLuxembourg\tI-ORG\n(\tO\nLuxembourg\tB-LOC\n)\tO\n0\tO\nVarteks\tB-ORG\nVarazdin\tI-ORG\n\n(\tO\nCroatia\tB-LOC\n)\tO\n3\tO\n(\tO\n0-0\tO\n)\tO\n\nScorers\tO\n:\tO\nDrazen\tB-PER\nBeser\tI-PER\n(\tO\n63rd\tO\n)\tO\n,\tO\nMiljenko\tB-PER\nMumler\tI-PER\n(\tO\npenalty\tO\n,\tO\n\n78th\tO\n)\tO\n,\tO\nJamir\tB-PER\nCvetko\tI-PER\n(\tO\n87th\tO\n)\tO\n\nVarteks\tB-ORG\nVarazdin\tI-ORG\nwin\tO\n5-1\tO\non\tO\naggregate\tO\n.\tO\n\nIn\tO\nTorshavn\tB-LOC\n:\tO\nHavnar\tB-ORG\nBoltfelag\tI-ORG\n(\tO\nFaroe\tB-LOC\nIslands\tI-LOC\n)\tO\n0\tO\nDynamo\tB-ORG\n\nBatumi\tB-ORG\n(\tO\nGeorgia\tB-LOC\n)\tO\n3\tO\n(\tO\n0-2\tO\n)\tO\n\nIn\tO\nPrague\tB-LOC\n:\tO\nSparta\tB-ORG\nPrague\tI-ORG\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n8\tO\nGlentoran\tB-ORG\n\n(\tO\nNorthern\tB-LOC\nIreland\tI-LOC\n)\tO\n0\tO\n(\tO\n4-0\tO\n)\tO\n\nScorers\tO\n:\tO\nPetr\tB-PER\nGunda\tI-PER\n(\tO\n1st\tO\nand\tO\n26th\tO\n)\tO\n,\tO\nLumir\tB-PER\nMistr\tI-PER\n(\tO\n19th\tO\n)\tO\n,\tO\n\nHorst\tB-PER\nSiegl\tI-PER\n(\tO\n24th\tO\n,\tO\n48th\tO\n,\tO\n80th\tO\n)\tO\n,\tO\nZdenek\tB-PER\nSvoboda\tI-PER\n(\tO\n76th\tO\n)\tO\n,\tO\nPetr\tB-PER\n\nGabriel\tB-PER\n(\tO\n86th\tO\n)\tO\n\nSparta\tB-ORG\nwin\tO\n10-1\tO\non\tO\naggregate\tO\n.\tO\n\nIn\tO\nEdinburgh\tB-LOC\n:\tO\nHearts\tB-ORG\n(\tO\nScotland\tB-LOC\n)\tO\n1\tO\nRed\tB-ORG\nStar\tI-ORG\nBelgrade\tI-ORG\n\nHearts\tB-ORG\n-\tO\nDave\tB-PER\nMcPherson\tI-PER\n(\tO\n44th\tO\n)\tO\n\nRed\tB-ORG\nStar\tI-ORG\n-\tO\nVinko\tB-MISC\nMarinovic\tI-MISC\n(\tO\n59th\tO\n)\tO\n\nRed\tB-ORG\nStar\tI-ORG\nwin\tO\non\tO\naway\tO\ngoals\tO\nrule\tO\n.\tO\n\nIn\tO\nRishon-Lezion\tB-LOC\n:\tO\nHapoel\tB-ORG\nIroni\tI-ORG\n(\tO\nIsrael\tB-LOC\n)\tO\n3\tO\nConstructorul\tB-ORG\n\nChisinau\tB-ORG\n(\tO\nMoldova\tB-LOC\n)\tO\n2\tO\n(\tO\n2-1\tO\n)\tO\n\nConstructorul\tB-ORG\nwin\tO\non\tO\naway\tO\ngoals\tO\nrule\tO\n.\tO\n\nIn\tO\nAnjalonkoski\tB-MISC\n:\tO\nMyPa-47\tB-ORG\n(\tO\nFinland\tB-LOC\n)\tO\n1\tO\nKarabach\tB-ORG\nAgdam\tI-ORG\n\nMypa-47\tB-ORG\nwin\tO\n2-1\tO\non\tO\naggregate\tO\n.\tO\n\nIn\tO\nSkopje\tB-LOC\n:\tO\nSloga\tB-ORG\nJugomagnat\tI-ORG\n(\tO\nMacedonia\tB-LOC\n)\tO\n0\tO\nKispest\tO\nHonved\tO\n\n(\tO\nHungary\tB-LOC\n1\tO\n(\tO\n0-0\tO\n)\tO\n\nKispest\tB-ORG\nHonved\tI-ORG\nwin\tO\n2-0\tO\non\tO\naggregate\tO\n.\tO\n\nAdd\tB-ORG\nHapoel\tI-ORG\nIroni\tI-ORG\nv\tO\nConstructorul\tB-ORG\nChisinau\tI-ORG\n\nRishon\tB-ORG\n-\tO\nMoshe\tB-PER\nSabag\tI-PER\n(\tO\n10th\tO\nminute\tO\n)\tO\n,\tO\nNissan\tO\nKapeta\tO\n(\tO\n26th\tO\n)\tO\n,\tO\n\nTomas\tB-PER\nCibola\tI-PER\n(\tO\n58th\tO\n)\tO\n.\tO\n\nConstructorol\tB-ORG\n-\tO\nSergei\tB-PER\nRogachev\tI-PER\n(\tO\n42nd\tO\n)\tO\n,\tO\nGennadi\tB-PER\nSkidan\tI-PER\n\nSOCCER\tO\n-\tO\nGOTHENBURG\tB-LOC\nPUT\tO\nFERENCVAROS\tB-ORG\nOUT\tO\nOF\tO\nEURO\tB-MISC\nCUP\tI-MISC\n.\tO\n\nIFK\tB-ORG\nGothenburg\tI-ORG\nof\tO\nSweden\tB-LOC\ndrew\tO\n1-1\tO\n(\tO\n1-0\tO\n)\tO\nwith\tO\nFerencvaros\tB-ORG\nof\tO\nHungary\tB-LOC\nin\tO\nthe\tO\nsecond\tO\nleg\tO\nof\tO\ntheir\tO\nEuropean\tB-MISC\nChampions\tI-MISC\nCup\tI-MISC\npreliminary\tO\nround\tO\ntie\tO\nplayed\tO\non\tO\nWednesday\tO\n.\tO\n\nGothenburg\tB-LOC\ngo\tO\nthrough\tO\n4-1\tO\non\tO\naggregate\tO\n.\tO\n\nSOCCER\tO\n-\tO\nBRAZILIAN\tB-MISC\nCHAMPIONSHIP\tO\nRESULTS\tO\n.\tO\n\nmatches\tO\nin\tO\nthe\tO\nBrazilian\tB-MISC\nsoccer\tO\nchampionship\tO\n.\tO\n\nBahia\tB-ORG\n2\tO\nAtletico\tB-ORG\nParanaense\tI-ORG\n0\tO\n\nCorinthians\tB-ORG\n1\tO\nGuarani\tO\n0\tO\n\nCoritiba\tB-ORG\n1\tO\nAtletico\tB-ORG\nMineiro\tI-ORG\n0\tO\n\nCruzeiro\tB-ORG\n2\tO\nVitoria\tO\n1\tO\n\nFlamengo\tB-ORG\n0\tO\nJuventude\tB-ORG\n1\tO\n\nGoias\tB-ORG\n3\tO\nSport\tB-ORG\nRecife\tI-ORG\n1\tO\n\nGremio\tB-ORG\n6\tO\nBragantino\tB-ORG\n1\tO\n\nPalmeiras\tB-ORG\n3\tO\nVasco\tB-ORG\nda\tI-ORG\nGama\tI-ORG\n1\tO\n\nPortuguesa\tB-ORG\n2\tO\nParana\tO\n0\tO\n\nTENNIS\tO\n-\tO\nNEWCOMBE\tB-PER\nPONDERS\tO\nHIS\tO\nDAVIS\tB-MISC\nCUP\tI-MISC\nFUTURE\tO\n.\tO\n\nAustralian\tB-MISC\nDavis\tB-MISC\nCup\tI-MISC\ncaptain\tO\nJohn\tB-PER\nNewcombe\tI-PER\non\tO\nThursday\tO\nsignalled\tO\nhis\tO\npossible\tO\nresignation\tO\nif\tO\nhis\tO\nteam\tO\nloses\tO\nan\tO\naway\tO\ntie\tO\nagainst\tO\nCroatia\tB-LOC\nnext\tO\nmonth\tO\n.\tO\n\nThe\tO\nformer\tO\nWimbledon\tB-MISC\nchampion\tO\nsaid\tO\nthe\tO\nimmediate\tO\nfuture\tO\nof\tO\nAustralia\tB-LOC\n's\tO\nDavis\tB-MISC\nCup\tI-MISC\ncoach\tO\nTony\tB-PER\nRoche\tI-PER\ncould\tO\nalso\tO\nbe\tO\ndetermined\tO\nby\tO\nevents\tO\nin\tO\nSplit\tB-LOC\n.\tO\n\n\"\tO\nIf\tO\nwe\tO\nlose\tO\nthis\tO\none\tO\n,\tO\nTony\tB-PER\nand\tO\nI\tO\nwill\tO\nhave\tO\nto\tO\nhave\tO\na\tO\ngood\tO\nlook\tO\nat\tO\ngiving\tO\nsomeone\tO\nelse\tO\na\tO\ngo\tO\n,\tO\n\"\tO\nNewcombe\tB-PER\nwas\tO\nquoted\tO\nas\tO\nsaying\tO\nin\tO\nSydney\tB-LOC\n's\tO\nDaily\tB-ORG\nTelegraph\tI-ORG\nnewspaper\tO\n.\tO\n\nAustralia\tB-LOC\nface\tO\nCroatia\tB-LOC\nin\tO\nthe\tO\nworld\tO\ngroup\tO\nqualifying\tO\ntie\tO\non\tO\nclay\tO\nfrom\tO\nSeptember\tO\n20-22\tO\n.\tO\n\nUnder\tO\nNewcombe\tB-PER\n's\tO\nleadership\tO\n,\tO\nAustralia\tB-LOC\nwere\tO\nrelegated\tO\nfrom\tO\nthe\tO\nelite\tO\nworld\tO\ngroup\tO\nlast\tO\nyear\tO\n,\tO\nthe\tO\nfirst\tO\ntime\tO\nthe\tO\n26-time\tO\nDavis\tB-MISC\nCup\tI-MISC\nwinners\tO\nhad\tO\nslipped\tO\nfrom\tO\nthe\tO\ntop\tO\nrank\tO\n.\tO\n\nSince\tO\ntaking\tO\nover\tO\nas\tO\ncaptain\tO\nfrom\tO\nNeale\tB-PER\nFraser\tI-PER\nin\tO\n1994\tO\n,\tO\nNewcombe\tB-PER\n's\tO\nrecord\tO\nin\tO\ntandem\tO\nwith\tO\nRoche\tB-PER\n,\tO\nhis\tO\nformer\tO\ndoubles\tO\npartner\tO\n,\tO\nhas\tO\nbeen\tO\nthree\tO\nwins\tO\nand\tO\nthree\tO\nlosses\tO\n.\tO\n\nNewcombe\tB-PER\nhas\tO\nselected\tO\nWimbledon\tB-MISC\nsemifinalist\tO\nJason\tO\nStoltenberg\tO\n,\tO\nPatrick\tB-PER\nRafter\tI-PER\n,\tO\nMark\tB-PER\nPhilippoussis\tI-PER\n,\tO\nand\tO\nOlympic\tB-MISC\ndoubles\tO\nchampions\tO\nTodd\tB-PER\nWoodbridge\tI-PER\nand\tO\nMark\tB-PER\nWoodforde\tI-PER\nto\tO\nface\tO\nthe\tO\nCroatians\tB-MISC\n.\tO\n\nThe\tO\nhome\tO\nside\tO\nboasts\tO\nworld\tO\nnumber\tO\nsix\tO\nGoran\tB-PER\nIvanisevic\tI-PER\n,\tO\nand\tO\nNewcombe\tB-PER\nconceded\tO\nhis\tO\nplayers\tO\nwould\tO\nbe\tO\nhard-pressed\tO\nto\tO\nbeat\tO\nthe\tO\nCroatian\tB-MISC\nnumber\tO\none\tO\n.\tO\n\n\"\tO\nWe\tO\nare\tO\nready\tO\nto\tO\nfight\tO\nto\tO\nour\tO\nlast\tO\nbreath\tO\n--\tO\nAustralia\tB-LOC\nmust\tO\nplay\tO\nat\tO\nits\tO\nabsolute\tO\nbest\tO\nto\tO\nwin\tO\n,\tO\n\"\tO\nsaid\tO\nNewcombe\tB-PER\n,\tO\nwho\tO\ndescribed\tO\nthe\tO\ntie\tO\nas\tO\nthe\tO\ntoughest\tO\nhe\tO\nhas\tO\nfaced\tO\nas\tO\ncaptain\tO\n.\tO\n\nAustralia\tB-LOC\nlast\tO\nwon\tO\nthe\tO\nDavis\tB-MISC\nCup\tI-MISC\nin\tO\n1986\tO\n,\tO\nbut\tO\nthey\tO\nwere\tO\nbeaten\tO\nfinalists\tO\nagainst\tO\nGermany\tB-LOC\nthree\tO\nyears\tO\nago\tO\nunder\tO\nFraser\tB-PER\n's\tO\nguidance\tO\n.\tO\n\nBADMINTON\tO\n-\tO\nMALAYSIAN\tB-MISC\nOPEN\tI-MISC\nRESULTS\tO\n.\tO\n\nResults\tO\nin\tO\nthe\tO\nMalaysian\tB-MISC\n\nOpen\tB-MISC\nbadminton\tO\ntournament\tO\non\tO\nThursday\tO\n(\tO\nprefix\tO\nnumber\tO\ndenotes\tO\n\n9/16\tO\n-\tO\nLuo\tB-PER\nYigang\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nHwang\tB-PER\nSun-ho\tB-MISC\n(\tO\nSouth\tB-LOC\nKorea\tI-LOC\n)\tO\n15-3\tO\n\nJason\tB-PER\nWong\tI-PER\n(\tO\nMalaysia\tB-LOC\n)\tO\nbeat\tO\nAbdul\tB-PER\nSamad\tI-PER\nIsmail\tI-PER\n(\tO\nMalaysia\tB-LOC\n)\tO\n16-18\tO\n\nP.\tB-PER\nKantharoopan\tI-PER\n(\tO\nMalaysia\tB-LOC\n)\tO\nbeat\tO\n3/4\tO\n-\tO\nJeroen\tB-PER\nVan\tI-PER\nDijk\tI-PER\n\n(\tO\nNetherlands\tB-LOC\n)\tO\n15-11\tO\n18-14\tO\n\nWijaya\tB-PER\nIndra\tI-PER\n(\tO\nIndonesia\tB-LOC\n)\tO\nbeat\tO\n5/8\tO\n-\tO\nPang\tB-PER\nChen\tI-PER\n(\tO\nMalaysia\tB-LOC\n)\tO\n15-6\tO\n\n3/4\tO\n-\tO\nHu\tB-PER\nZhilan\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nNunung\tB-PER\nSubandoro\tI-PER\n(\tO\nIndonesia\tB-LOC\n)\tO\n5-15\tO\n\n9/16\tO\n-\tO\nHermawan\tB-PER\nSusanto\tI-PER\n(\tO\nIndonesia\tB-LOC\n)\tO\nbeat\tO\n1\tO\n-\tO\nFung\tB-PER\nPermadi\tI-PER\n(\tO\nTaiwan\tB-LOC\n)\tO\n\n1\tO\n-\tO\nWang\tB-PER\nChen\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nCindana\tO\n(\tO\nIndonesia\tB-LOC\n)\tO\n11-3\tO\n1ama\tB-PER\n(\tO\nJapan\tB-LOC\n)\tO\nbeat\tO\nMargit\tB-PER\nBorg\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\n11-6\tO\n11-6\tO\n\nSun\tB-PER\nJian\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nMarina\tB-PER\nAndrievskaqya\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\n11-8\tO\n11-2\tO\n\n5/8\tO\n-\tO\nMeluawati\tB-PER\n(\tO\nIndonesia\tB-LOC\n)\tO\nbeat\tO\nChan\tB-PER\nChia\tI-PER\nFong\tI-PER\n(\tO\nMalaysia\tB-LOC\n)\tO\n11-6\tO\n\nGong\tB-PER\nZhichao\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nLiu\tB-PER\nLufung\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\n6-11\tO\n11-7\tO\n11-3\tO\n\nZeng\tB-PER\nYaqiong\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nLi\tB-PER\nFeng\tI-PER\n(\tO\nNew\tB-LOC\nZealand\tI-LOC\n)\tO\n11-9\tO\n11-6\tO\n\n5/8\tO\n-\tO\nChristine\tB-PER\nMagnusson\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\nbeat\tO\nIshwari\tB-PER\nBoopathy\tI-PER\n\n2\tO\n-\tO\nZhang\tB-PER\nNing\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nOlivia\tB-PER\n(\tO\nIndonesia\tB-LOC\n)\tO\n11-8\tO\n11-6\tO\n\nTENNIS\tO\n-\tO\nREVISED\tO\nMEN\tO\n'S\tO\nDRAW\tO\nFOR\tO\nU.S.\tB-MISC\nOPEN\tI-MISC\n.\tO\n\nU.S.\tB-MISC\nOpen\tI-MISC\ntennis\tO\nchampionships\tO\nbeginning\tO\nMonday\tO\nat\tO\nthe\tO\nU.S\tB-LOC\n.\tO\n\nNational\tB-LOC\nTennis\tI-LOC\nCentre\tI-LOC\n(\tO\nprefix\tO\ndenotes\tO\nseeding\tO\n)\tO\n:\tO\n\n1\tO\n-\tO\nPete\tB-PER\nSampras\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nAdrian\tB-PER\nVoinea\tI-PER\n(\tO\nRomania\tB-LOC\n)\tO\n\nJiri\tB-PER\nNovak\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nvs.\tO\nqualifier\tO\n\nMagnus\tB-PER\nLarsson\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tO\nAlexander\tB-PER\nVolkov\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n\nMikael\tB-PER\nTillstrom\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\nvs\tO\nqualifier\tO\n\nQualifier\tO\nvs.\tO\nAndrei\tB-PER\nOlhovskiy\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n\nMark\tB-PER\nWoodforde\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nMark\tB-PER\nPhilippoussis\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n\nRoberto\tB-PER\nCarretero\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tO\nJordi\tO\nBurillo\tO\n(\tO\nSpain\tB-LOC\n)\tO\n\nFrancisco\tB-PER\nClavet\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tO\n16\tO\n-\tO\nCedric\tB-PER\nPioline\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\n\n9\tO\n-\tO\nWayne\tB-PER\nFerreira\tI-PER\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\nvs.\tO\nqualifier\tO\n\nKarol\tB-PER\nKucera\tI-PER\n(\tO\nSlovakia\tB-LOC\n)\tO\nvs.\tO\nJonas\tB-PER\nBjorkman\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\n\nQualifier\tO\nvs.\tO\nChristian\tB-PER\nRudd\tI-PER\n(\tO\nNorway\tB-LOC\n)\tO\n\nAlex\tB-PER\nCorretja\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tO\nByron\tB-PER\nBlack\tI-PER\n(\tO\nZimbabwe\tO\n)\tO\n\nDavid\tB-PER\nRikl\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nvs.\tO\nHicham\tB-PER\nArazi\tI-PER\n(\tO\nMorocco\tB-LOC\n)\tO\n\nSjeng\tB-PER\nSchalken\tI-PER\n(\tO\nNetherlands\tB-LOC\n)\tO\nvs.\tO\nGilbert\tB-PER\nSchaller\tI-PER\n(\tO\nAustria\tB-LOC\n)\tO\n\nGrant\tB-PER\nStafford\tI-PER\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\nvs.\tO\nGuy\tB-PER\nForget\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\n\nFernando\tB-PER\nMeligeni\tI-PER\n(\tO\nBrazil\tB-LOC\n)\tO\nvs.\tO\n7\tO\n-\tO\nYevgeny\tB-PER\nKafelnikov\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n\n4\tO\n-\tO\nGoran\tB-PER\nIvanisevic\tI-PER\n(\tO\nCroatia\tB-LOC\n)\tO\nvs.\tO\nAndrei\tB-PER\nChesnokov\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n\nScott\tB-PER\nDraper\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nGalo\tB-PER\nBlanco\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n\nRenzo\tB-PER\nFurlan\tI-PER\n(\tO\nItaly\tB-LOC\n)\tO\nvs.\tO\nThomas\tB-PER\nJohansson\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\n\nHendrik\tB-PER\nDreekman\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\nvs.\tO\nGreg\tB-PER\nRusedski\tI-PER\n(\tO\nBritain\tB-LOC\n)\tO\n\nAndrei\tB-PER\nMedvedev\tI-PER\n(\tO\nUkraine\tO\n)\tO\nvs.\tO\nJean-Philippe\tB-PER\nFleurian\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\n\nJan\tB-PER\nKroslak\tI-PER\n(\tO\nSlovakia\tB-LOC\n)\tO\nvs.\tO\nChris\tB-PER\nWoodruff\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n\nQualifier\tO\nvs.\tO\nPetr\tB-PER\nKorda\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n\nBohdan\tB-PER\nUlihrach\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nvs.\tO\n14\tO\n-\tO\nAlberto\tO\nCosta\tO\n\n12\tO\n-\tO\nTodd\tB-PER\nMartin\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nYounnes\tB-PER\nEl\tI-PER\nAynaoui\tI-PER\n(\tO\nMorocco\tB-LOC\n)\tO\n\nAndrea\tB-PER\nGaudenzi\tI-PER\n(\tO\nItaly\tB-LOC\n)\tO\nvs.\tO\nShuzo\tB-PER\nMatsuoka\tI-PER\n(\tO\nJapan\tB-LOC\n)\tO\n\nDoug\tB-PER\nFlach\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nqualifier\tO\n\nMats\tB-PER\nWilander\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tO\nTim\tB-PER\nHenman\tI-PER\n(\tO\nBritain\tB-LOC\n)\tO\n\nPaul\tB-PER\nHaarhuis\tI-PER\n(\tO\nNetherlands\tB-LOC\n)\tO\nvs.\tO\nMichael\tB-PER\nJoyce\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n\nMichael\tB-PER\nTebbutt\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nRichey\tB-PER\nReneberg\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n\nJonathan\tB-PER\nStark\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nBernd\tB-PER\nKarbacher\tI-PER\n(\tO\nGermany\tO\n)\tO\n\nStefan\tB-PER\nEdberg\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tO\n5\tO\n-\tO\nRichard\tB-PER\nKrajicek\tI-PER\n(\tO\nNetherlands\tB-LOC\n)\tO\n\n6\tO\n-\tO\nAndre\tB-PER\nAgassi\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nMauricio\tB-PER\nHadad\tI-PER\n(\tO\nColombia\tO\n)\tO\n\nMarcos\tB-PER\nOndruska\tI-PER\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\nvs.\tO\nFelix\tB-PER\nMantilla\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n\nCarlos\tO\nMoya\tO\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tO\nScott\tB-PER\nHumphries\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n\nJan\tB-PER\nSiemerink\tI-PER\n(\tO\nNetherlands\tB-LOC\n)\tO\nvs.\tO\nCarl-Uwe\tB-PER\nSteeb\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\n\nDavid\tB-PER\nWheaton\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nKevin\tB-PER\nKim\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n\nNicolas\tB-PER\nLapentti\tI-PER\n(\tO\nEcuador\tB-LOC\n)\tO\nvs.\tO\nAlex\tO\nO'Brien\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n\nKarim\tB-PER\nAlami\tI-PER\n(\tO\nMorocco\tB-LOC\n)\tO\nvs.\tO\n11\tO\n-\tO\nMaliVai\tB-PER\nWashington\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n\n13\tO\n-\tO\nThomas\tB-PER\nEnqvist\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tO\nStephane\tB-PER\nSimian\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\n\nGuillaume\tB-PER\nRaoux\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\nvs.\tO\nFilip\tB-PER\nDewulf\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\n\nMark\tO\nKnowles\tO\n(\tO\nBahamas\tO\n)\tO\nvs.\tO\nMarcelo\tO\nFilippini\tO\n(\tO\nUruguay\tB-LOC\n)\tO\n\nTodd\tB-PER\nWoodbridge\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nqualifier\tO\n\nKris\tB-PER\nGoossens\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\nvs.\tO\nSergi\tB-PER\nBruguera\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n\nQualifier\tO\nvs.\tO\nMichael\tO\nStich\tO\n(\tO\nGermany\tB-LOC\n)\tO\n\nQualifier\tO\nvs.\tO\nChuck\tB-PER\nAdams\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n\nJavier\tB-PER\nFrana\tI-PER\n(\tO\nArgentina\tO\n)\tO\nvs.\tO\n3\tO\n-\tO\nThomas\tB-PER\nMuster\tI-PER\n(\tO\nAustria\tB-LOC\n)\tO\n\n8\tO\n-\tO\nJim\tB-PER\nCourier\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nJavier\tB-PER\nSanchez\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n\nJim\tB-PER\nGrabb\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nSandon\tB-PER\nStolle\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n\nPatrick\tB-PER\nRafter\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nKenneth\tB-PER\nCarlsen\tI-PER\n(\tO\nDenmark\tB-LOC\n)\tO\n\nJason\tB-PER\nStoltenberg\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nStefano\tB-PER\nPescosolido\tI-PER\n(\tO\nItaly\tB-LOC\n)\tO\n\nArnaud\tB-PER\nBoetsch\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\nvs.\tO\nNicolas\tB-PER\nPereira\tI-PER\n(\tO\nVenezuela\tB-LOC\n)\tO\n\nCarlos\tB-PER\nCosta\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tO\nMagnus\tB-PER\nGustafsson\tI-PER\n(\tO\nSweden\tO\n)\tO\n\nJeff\tB-PER\nTarango\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nAlex\tB-PER\nRadulescu\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\n\nQualifier\tO\nvs.\tO\n10\tO\n-\tO\nMarcelo\tB-PER\nRios\tI-PER\n(\tO\nChile\tO\n)\tO\n\n15\tO\n-\tO\nMarc\tO\nRosset\tO\n(\tO\nSwitzerland\tB-LOC\nvs.\tO\nJared\tO\nPalmer\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n\nMartin\tB-PER\nDamm\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nvs.\tO\nHernan\tO\nGumy\tO\n(\tO\nArgentina\tB-LOC\n)\tO\n\nNicklas\tB-PER\nKulti\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tO\nJakob\tB-PER\nHlasek\tI-PER\n(\tO\nSwitzerland\tB-LOC\n)\tO\n\nCecil\tB-PER\nMamiit\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nAlberto\tB-PER\nBerasategui\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n\nVince\tB-PER\nSpadea\tI-PER\n(\tO\nU.S.\tO\n)\tO\nvs.\tO\nDaniel\tB-PER\nVacek\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n\nDavid\tB-PER\nPrinosil\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\nvs.\tO\nqualifier\tO\n\nQualifier\tO\nvs.\tO\nTomas\tB-PER\nCarbonell\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n\nQualifier\tO\nvs.\tO\n2\tO\n-\tO\nMichael\tB-PER\nChang\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n\nBASEBALL\tO\n-\tO\nORIOLES\tB-ORG\n'\tO\nMANAGER\tO\nDAVEY\tB-PER\nJOHNSON\tI-PER\nHOSPITALIZED\tO\n.\tO\n\nBaltimore\tB-ORG\nOrioles\tI-ORG\nmanager\tO\nDavey\tO\nJohnson\tO\nwill\tO\nmiss\tO\nThursday\tO\nnight\tO\n's\tO\ngame\tO\nagainst\tO\nthe\tO\nSeattle\tB-ORG\nMariners\tI-ORG\nafter\tO\nbeing\tO\nadmitted\tO\nto\tO\na\tO\nhospital\tO\nwith\tO\nan\tO\nirregular\tO\nheartbeat\tO\n.\tO\n\nThe\tO\n53-year-old\tO\nJohnson\tB-PER\nwas\tO\nhospitalized\tO\nafter\tO\nexperiencing\tO\ndizziness\tO\n.\tO\n\n\"\tO\nHe\tO\nis\tO\nin\tO\nno\tO\ndanger\tO\nand\tO\nwill\tO\nbe\tO\ntreated\tO\nand\tO\nobserved\tO\nthis\tO\nevening\tO\n,\tO\n\"\tO\nsaid\tO\nOrioles\tB-ORG\nteam\tO\nphysician\tO\nDr.\tO\nWilliam\tB-PER\nGoldiner\tI-PER\n,\tO\nadding\tO\nthat\tO\nJohnson\tB-PER\nis\tO\nexpected\tO\nto\tO\nbe\tO\nreleased\tO\non\tO\nFriday\tO\n.\tO\n\nOrioles\tB-ORG\n'\tO\nbench\tO\ncoach\tO\nAndy\tB-PER\nEtchebarren\tI-PER\nwill\tO\nmanage\tO\nthe\tO\nclub\tO\nin\tO\nJohnson\tB-PER\n's\tO\nabsence\tO\n.\tO\n\nJohnson\tB-PER\nis\tO\nthe\tO\nsecond\tO\nmanager\tO\nto\tO\nbe\tO\nhospitalized\tO\nthis\tO\nweek\tO\nafter\tO\nCalifornia\tB-ORG\nAngels\tI-ORG\nskipper\tO\nJohn\tB-PER\nMcNamara\tI-PER\nwas\tO\nadmitted\tO\nto\tO\nNew\tB-LOC\nYork\tI-LOC\n's\tO\nColumbia\tB-LOC\nPresbyterian\tI-LOC\nHospital\tI-LOC\non\tO\nWednesday\tO\nwith\tO\na\tO\nblood\tO\nclot\tO\nin\tO\nhis\tO\nleft\tO\ncalf\tO\n.\tO\n\nJohnson\tB-PER\n,\tO\nwho\tO\nplayed\tO\neight\tO\nseasons\tO\nin\tO\nBaltimore\tB-LOC\n,\tO\nwas\tO\nnamed\tO\nOrioles\tB-ORG\nmanager\tO\nin\tO\nthe\tO\noff-season\tO\nreplacing\tO\nPhil\tB-PER\nRegan\tI-PER\n.\tO\n\nHe\tO\nled\tO\nthe\tO\nCincinnati\tB-ORG\nReds\tI-ORG\nto\tO\nthe\tO\nNational\tB-MISC\nLeague\tI-MISC\nChampionship\tI-MISC\nSeries\tI-MISC\nlast\tO\nyear\tO\nand\tO\nguided\tO\nthe\tO\nNew\tB-ORG\nYork\tI-ORG\nMets\tI-ORG\nto\tO\na\tO\nWorld\tB-MISC\nSeries\tI-MISC\nchampionship\tO\nin\tO\n1986\tO\n.\tO\n\nBaltimore\tB-ORG\nhas\tO\nwon\tO\n16\tO\nof\tO\nits\tO\nlast\tO\n22\tO\ngames\tO\nto\tO\npull\tO\nwithin\tO\nfive\tO\ngames\tO\nof\tO\nthe\tO\nslumping\tO\nNew\tB-ORG\nYork\tI-ORG\nYankees\tI-ORG\nin\tO\nthe\tO\nAmerican\tB-MISC\nLeague\tI-MISC\nEast\tI-MISC\nDivision\tI-MISC\n.\tO\n\nNEW\tB-ORG\nYORK\tI-ORG\n72\tO\n53\tO\n.576\tO\n-\tO\n\nBOSTON\tB-ORG\n63\tO\n64\tO\n.496\tO\n10\tO\n\nTORONTO\tB-ORG\n58\tO\n69\tO\n.457\tO\n15\tO\n\nCLEVELAND\tB-ORG\n76\tO\n51\tO\n.598\tO\n-\tO\n\nCHICAGO\tB-ORG\n69\tO\n59\tO\n.539\tO\n7\tO\n1/2\tO\n\nSEATTLE\tB-ORG\n64\tO\n61\tO\n.512\tO\n8\tO\n\nOAKLAND\tB-ORG\n62\tO\n67\tO\n.481\tO\n12\tO\n\nCALIFORNIA\tB-ORG\n58\tO\n68\tO\n.460\tO\n14\tO\n1/2\tO\n\nOAKLAND\tB-ORG\nAT\tO\nBOSTON\tB-LOC\n\nSEATTLE\tB-ORG\nAT\tO\nBALTIMORE\tB-LOC\n\nCALIFORNIA\tB-ORG\nAT\tO\nNEW\tB-LOC\nYORK\tI-LOC\n\nTORONTO\tO\nAT\tO\nCHICAGO\tB-LOC\n\nDETROIT\tB-ORG\nAT\tO\nKANSAS\tB-LOC\nCITY\tI-LOC\n\nTEXAS\tB-ORG\nAT\tO\nMINNESOTA\tB-LOC\n\nMONTREAL\tB-ORG\n67\tO\n58\tO\n.536\tO\n12\tO\n\nPHILADELPHIA\tB-ORG\n52\tO\n75\tO\n.409\tO\n28\tO\n\nCHICAGO\tB-ORG\n63\tO\n62\tO\n.504\tO\n4\tO\n\nCINCINNATI\tB-ORG\n62\tO\n62\tO\n.500\tO\n4\tO\n1/2\tO\n\nPITTSBURGH\tB-ORG\n53\tO\n73\tO\n.421\tO\n14\tO\n1/2\tO\n\nCOLORADO\tB-ORG\n65\tO\n62\tO\n.512\tO\n4\tO\n\nSAN\tB-ORG\nFRANCISCO\tI-ORG\n54\tO\n70\tO\n.435\tO\n13\tO\n1/2\tO\n\nST\tO\nLOUIS\tO\nAT\tO\nCOLORADO\tB-LOC\n\nCINCINNATI\tB-ORG\nAT\tO\nATLANTA\tO\n\nPITTSBURGH\tB-ORG\nAT\tO\nHOUSTON\tB-LOC\n\nPHILADELPHIA\tB-ORG\nAT\tO\nLOS\tB-LOC\nANGELES\tI-LOC\n\nMONTREAL\tB-ORG\nAT\tO\nSAN\tO\nFRANCISCO\tO\n\nResults\tO\nof\tO\nMajor\tB-MISC\nLeague\tI-MISC\n\nCalifornia\tB-ORG\n7\tO\nNEW\tB-ORG\nYORK\tI-ORG\n1\tO\n\nDETROIT\tB-ORG\n7\tO\nChicago\tO\n4\tO\n\nMilwaukee\tB-ORG\n10\tO\nMINNESOTA\tB-ORG\n7\tO\n\nBOSTON\tO\n6\tO\nOakland\tB-ORG\n4\tO\n\nBALTIMORE\tB-ORG\n10\tO\nSeattle\tB-ORG\n5\tO\n\nTexas\tB-ORG\n10\tO\nCLEVELAND\tB-ORG\n8\tO\n(\tO\nin\tO\n10\tO\n)\tO\n\nToronto\tB-ORG\n6\tO\nKANSAS\tB-ORG\nCITY\tI-ORG\n2\tO\n\nCHICAGO\tB-ORG\n8\tO\nFlorida\tB-ORG\n3\tO\n\nSAN\tB-ORG\nFRANCISCO\tI-ORG\n12\tO\nNew\tB-ORG\nYork\tI-ORG\n11\tO\n\nATLANTA\tB-ORG\n4\tO\nCincinnati\tB-ORG\n3\tO\n\nPittsburgh\tB-ORG\n5\tO\nHOUSTON\tB-ORG\n2\tO\n\nCOLORADO\tB-ORG\n10\tO\nSt\tB-ORG\nLouis\tI-ORG\n2\tO\n\nPhiladelphia\tB-ORG\n6\tO\nLOS\tO\nANGELES\tO\n0\tO\n\nSAN\tB-ORG\nDIEGO\tI-ORG\n7\tO\nMontreal\tB-ORG\n2\tO\n\nBASEBALL\tO\n-\tO\nGREER\tB-PER\nHOMER\tO\nIN\tO\n10TH\tO\nLIFTS\tO\nTEXAS\tB-ORG\nPAST\tO\nINDIANS\tB-ORG\n.\tO\n\nRusty\tB-PER\nGreer\tI-PER\n's\tO\ntwo-run\tO\nhomer\tO\nin\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\n10th\tO\ninning\tO\nrallied\tO\nthe\tO\nTexas\tB-ORG\nRangers\tI-ORG\nto\tO\na\tO\n10-8\tO\nvictory\tO\nover\tO\nthe\tO\nCleveland\tB-ORG\nIndians\tI-ORG\nWednesday\tO\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\na\tO\nthree-game\tO\nseries\tO\nbetween\tO\ndivision\tO\nleaders\tO\n.\tO\n\nWith\tO\none\tO\nout\tO\n,\tO\nGreer\tB-PER\nhit\tO\na\tO\n1-1\tO\npitch\tO\nfrom\tO\nJulian\tB-PER\nTavarez\tI-PER\n(\tO\n4-7\tO\n)\tO\nover\tO\nthe\tO\nright-field\tO\nfence\tO\nfor\tO\nhis\tO\n15th\tO\nhome\tO\nrun\tO\n.\tO\n\n\"\tO\nIt\tO\nwas\tO\nan\tO\noff-speed\tO\npitch\tO\nand\tO\nI\tO\njust\tO\ntried\tO\nto\tO\nget\tO\na\tO\ngood\tO\nswing\tO\non\tO\nit\tO\nand\tO\nput\tO\nit\tO\nin\tO\nplay\tO\n,\tO\n\"\tO\nGreer\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\nThe\tO\nshot\tO\nbrought\tO\nhome\tO\nIvan\tB-PER\nRodriguez\tI-PER\n,\tO\nwho\tO\nhad\tO\nhis\tO\nsecond\tO\ndouble\tO\nof\tO\nthe\tO\ngame\tO\n,\tO\ngiving\tO\nhim\tO\n42\tO\nthis\tO\nseason\tO\n,\tO\n41\tO\nas\tO\na\tO\ncatcher\tO\n.\tO\n\nHe\tO\njoined\tO\nMickey\tB-PER\nCochrane\tI-PER\n,\tO\nJohnny\tB-PER\nBench\tI-PER\nand\tO\nTerry\tB-PER\nKennedy\tI-PER\nas\tO\nthe\tO\nonly\tO\ncatchers\tO\nwith\tO\n40\tO\ndoubles\tO\nin\tO\na\tO\nseason\tO\n.\tO\n\nThe\tO\nRangers\tB-ORG\nhave\tO\nwon\tO\n10\tO\nof\tO\ntheir\tO\nlast\tO\n12\tO\ngames\tO\nand\tO\nsix\tO\nof\tO\nnine\tO\nmeetings\tO\nagainst\tO\nthe\tO\nIndians\tB-ORG\nthis\tO\nseason\tO\n.\tO\n\nThe\tO\nAmerican\tB-MISC\nLeague\tI-MISC\nWestern\tI-MISC\nleaders\tO\nhave\tO\nwon\tO\neight\tO\nof\tO\n15\tO\ngames\tO\nat\tO\nJacobs\tB-LOC\nField\tI-LOC\n,\tO\njoining\tO\nthe\tO\nYankees\tB-ORG\nas\tO\nthe\tO\nonly\tO\nteams\tO\nwith\tO\na\tO\nwinning\tO\nrecord\tO\nat\tO\nthe\tO\nA.L.\tB-MISC\nCentral\tI-MISC\nleaders\tO\n'\tO\nhome\tO\n.\tO\n\nThe\tO\nIndians\tB-ORG\nsent\tO\nthe\tO\ngame\tO\ninto\tO\nextra\tO\ninnings\tO\nin\tO\nthe\tO\nninth\tO\non\tO\nKenny\tB-PER\nLofton\tI-PER\n's\tO\ntwo-run\tO\nsingle\tO\n.\tO\n\nEd\tB-PER\nVosberg\tI-PER\n(\tO\n1-0\tO\n)\tO\nblew\tO\nhis\tO\nfirst\tO\nsave\tO\nopportunity\tO\nbut\tO\ngot\tO\nthe\tO\nwin\tO\n,\tO\nallowing\tO\nthree\tO\nhits\tO\nwith\tO\ntwo\tO\nwalks\tO\nand\tO\nthree\tO\nstrikeouts\tO\nin\tO\n1\tO\n2/3\tO\nscoreless\tO\ninnings\tO\n.\tO\n\nDean\tB-PER\nPalmer\tI-PER\nhit\tO\nhis\tO\n30th\tO\nhomer\tO\nfor\tO\nthe\tO\nRangers\tB-ORG\n.\tO\n\nIn\tO\nBaltimore\tB-LOC\n,\tO\nCal\tB-PER\nRipken\tI-PER\nhad\tO\nfour\tO\nhits\tO\nand\tO\nsnapped\tO\na\tO\nfifth-inning\tO\ntie\tO\nwith\tO\na\tO\nsolo\tO\nhomer\tO\nand\tO\nBobby\tB-PER\nBonilla\tI-PER\nadded\tO\na\tO\nthree-run\tO\nshot\tO\nin\tO\nthe\tO\nseventh\tO\nto\tO\npower\tO\nthe\tO\nsurging\tO\nOrioles\tB-ORG\nto\tO\na\tO\n10-5\tO\nvictory\tO\nover\tO\nthe\tO\nSeattle\tB-ORG\nMariners\tI-ORG\n.\tO\n\nThe\tO\nMariners\tB-ORG\nscored\tO\nfour\tO\nruns\tO\nin\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nfifth\tO\nto\tO\ntie\tO\nthe\tO\ngame\tO\n5-5\tO\nbut\tO\nRipken\tB-PER\nled\tO\noff\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\ninning\tO\nwith\tO\nhis\tO\n21st\tO\nhomer\tO\noff\tO\nstarter\tO\nSterling\tB-PER\nHitchcock\tI-PER\n(\tO\n12-6\tO\n)\tO\n.\tO\n\nBonilla\tB-PER\n's\tO\nblast\tO\nwas\tO\nthe\tO\nfirst\tO\ntime\tO\nRandy\tB-PER\nJohnson\tI-PER\n,\tO\nlast\tO\nseason\tO\n's\tO\nCy\tB-PER\nYoung\tI-PER\nwinner\tO\n,\tO\nallowed\tO\na\tO\nrun\tO\nin\tO\nfive\tO\nrelief\tO\nappearances\tO\nsince\tO\ncoming\tO\noff\tO\nthe\tO\ndisabled\tO\nlist\tO\non\tO\nAugust\tO\n6\tO\n.\tO\n\nBonilla\tB-PER\nhas\tO\n21\tO\nRBI\tB-MISC\nand\tO\n15\tO\nruns\tO\nin\tO\nhis\tO\nlast\tO\n20\tO\ngames\tO\n.\tO\n\nBaltimore\tB-LOC\nhas\tO\nwon\tO\nseven\tO\nof\tO\nnine\tO\nand\tO\n16\tO\nof\tO\nits\tO\nlast\tO\n22\tO\nand\tO\ncut\tO\nthe\tO\nYankees\tB-ORG\n'\tO\nlead\tO\nin\tO\nthe\tO\nA.L.\tB-MISC\nEast\tI-MISC\nto\tO\nfive\tO\ngames\tO\n.\tO\n\nScott\tB-PER\nErickson\tI-PER\n(\tO\n8-10\tO\n)\tO\nlaboured\tO\nto\tO\nhis\tO\nthird\tO\nstraight\tO\nwin\tO\n.\tO\n\nAlex\tB-PER\nRodriguez\tI-PER\nhad\tO\ntwo\tO\nhomers\tO\nand\tO\nfour\tO\nRBI\tB-MISC\nfor\tO\nthe\tO\nMariners\tB-ORG\n,\tO\nwho\tO\nhave\tO\ndropped\tO\nthree\tO\nin\tO\na\tO\nrow\tO\nand\tO\n11\tO\nof\tO\n15\tO\n.\tO\n\nHe\tO\nbecame\tO\nthe\tO\nfifth\tO\nshortstop\tO\nin\tO\nmajor-league\tO\nhistory\tO\nto\tO\nhit\tO\n30\tO\nhomers\tO\nin\tO\na\tO\nseason\tO\nand\tO\nthe\tO\nfirst\tO\nsince\tO\nRipken\tB-PER\nhit\tO\n34\tO\nin\tO\n1991\tO\n.\tO\n\nChris\tB-PER\nHoiles\tI-PER\nhit\tO\nhis\tO\n22nd\tO\nhomer\tO\nfor\tO\nBaltimore\tB-LOC\n.\tO\n\nIn\tO\nNew\tB-LOC\nYork\tI-LOC\n,\tO\nJason\tO\nDickson\tO\nscattered\tO\n10\tO\nhits\tO\nover\tO\n6\tO\n1/3\tO\ninnings\tO\nin\tO\nhis\tO\nmajor-league\tO\ndebut\tO\nand\tO\nChili\tB-PER\nDavis\tI-PER\nbelted\tO\na\tO\nhomer\tO\nfrom\tO\neach\tO\nside\tO\nof\tO\nthe\tO\nplate\tO\nas\tO\nthe\tO\nCalifornia\tB-ORG\nAngels\tI-ORG\ndefeated\tO\nthe\tO\nYankees\tB-ORG\n7-1\tO\n.\tO\n\nDickson\tB-PER\nallowed\tO\na\tO\nhomer\tO\nto\tO\nDerek\tB-PER\nJeter\tI-PER\non\tO\nhis\tO\nfirst\tO\nmajor-league\tO\npitch\tO\nbut\tO\nsettled\tO\ndown\tO\n.\tO\n\nHe\tO\nwas\tO\nthe\tO\n27th\tO\npitcher\tO\nused\tO\nby\tO\nthe\tO\nAngels\tB-ORG\nthis\tO\nseason\tO\n,\tO\ntying\tO\na\tO\nmajor-league\tO\nrecord\tO\n.\tO\n\nJimmy\tB-PER\nKey\tI-PER\n(\tO\n9-10\tO\n)\tO\ntook\tO\nthe\tO\nloss\tO\nas\tO\nthe\tO\nYankees\tB-ORG\nlost\tO\ntheir\tO\nninth\tO\nin\tO\n14\tO\ngames\tO\n.\tO\n\nCalifornia\tB-LOC\nplayed\tO\nwithout\tO\ninterim\tO\nmanager\tO\nJohn\tB-PER\nMcNamara\tI-PER\n,\tO\nwho\tO\nwas\tO\nadmitted\tO\nto\tO\na\tO\nNew\tB-LOC\nYork\tI-LOC\nhospital\tO\nwith\tO\na\tO\nblood\tO\nclot\tO\nin\tO\nhis\tO\nright\tO\ncalf\tO\n.\tO\n\nIn\tO\nBoston\tB-LOC\n,\tO\nMike\tB-PER\nStanley\tI-PER\n's\tO\nbases-loaded\tO\ntwo-run\tO\nsingle\tO\nsnapped\tO\nan\tO\neighth-inning\tO\ntie\tO\nand\tO\ngave\tO\nthe\tO\nRed\tB-ORG\nSox\tI-ORG\ntheir\tO\nthird\tO\nstraight\tO\nwin\tO\n,\tO\n6-4\tO\nover\tO\nthe\tO\nOakland\tB-ORG\nAthletics\tI-ORG\n.\tO\n\nBoston\tB-LOC\n's\tO\nMo\tB-PER\nVaughn\tI-PER\nwent\tO\n3-for-3\tO\nwith\tO\na\tO\nwalk\tO\n,\tO\nstole\tO\nhome\tO\nfor\tO\none\tO\nof\tO\nhis\tO\nthree\tO\nruns\tO\nscored\tO\nand\tO\ncollected\tO\nhis\tO\n116th\tO\nRBI\tB-MISC\n.\tO\n\nScott\tB-PER\nBrosius\tI-PER\nhomered\tO\nand\tO\ndrove\tO\nin\tO\ntwo\tO\nruns\tO\nfor\tO\nthe\tO\nAthletics\tB-ORG\n,\tO\nwho\tO\nhave\tO\nlost\tO\nseven\tO\nof\tO\ntheir\tO\nlast\tO\nnine\tO\ngames\tO\n.\tO\n\nIn\tO\nDetroit\tB-LOC\n,\tO\nBrad\tB-PER\nAusmus\tI-PER\n's\tO\nthree-run\tO\nhomer\tO\ncapped\tO\na\tO\nfour-run\tO\neighth\tO\nand\tO\nlifted\tO\nthe\tO\nTigers\tB-ORG\nto\tO\na\tO\n7-4\tO\nvictory\tO\nover\tO\nthe\tO\nreeling\tO\nChicago\tB-ORG\nWhite\tI-ORG\nSox\tI-ORG\n.\tO\n\nThe\tO\nTigers\tB-ORG\nhave\tO\nwon\tO\nconsecutive\tO\ngames\tO\nafter\tO\ndropping\tO\neight\tO\nin\tO\na\tO\nrow\tO\n,\tO\nbut\tO\nhave\tO\nwon\tO\nnine\tO\nof\tO\ntheir\tO\nlast\tO\n12\tO\nat\tO\nhome\tO\n.\tO\n\nThe\tO\nWhite\tB-ORG\nSox\tI-ORG\nhave\tO\nlost\tO\nsix\tO\nof\tO\ntheir\tO\nlast\tO\neight\tO\ngames\tO\n.\tO\n\nIn\tO\nKansas\tO\nCity\tO\n,\tO\nJuan\tB-PER\nGuzman\tI-PER\ntossed\tO\na\tO\ncomplete-game\tO\nsix-hitter\tO\nto\tO\nwin\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nover\tO\na\tO\nmonth\tO\nand\tO\nlower\tO\nhis\tO\nleague-best\tO\nERA\tB-MISC\nas\tO\nthe\tO\nToronto\tB-ORG\nBlue\tI-ORG\nJays\tI-ORG\nwon\tO\ntheir\tO\nfourth\tO\nstraight\tO\n,\tO\n6-2\tO\nover\tO\nthe\tO\nRoyals\tB-ORG\n.\tO\n\nGuzman\tB-PER\n(\tO\n10-8\tO\n)\tO\nwon\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nsince\tO\nJuly\tO\n16\tO\n,\tO\na\tO\nspan\tO\nof\tO\nsix\tO\nstarts\tO\n.\tO\n\nHe\tO\nallowed\tO\ntwo\tO\nruns\tO\n--\tO\none\tO\nearned\tO\n--\tO\nand\tO\nlowered\tO\nhis\tO\nERA\tB-MISC\nto\tO\n2.99\tO\n.\tO\n\nAt\tO\nMinnesota\tB-LOC\n,\tO\nJohn\tB-PER\nJaha\tI-PER\n's\tO\nthree-run\tO\nhomer\tO\n,\tO\nhis\tO\n26th\tO\n,\tO\ncapped\tO\na\tO\nfive-run\tO\neighth\tO\ninning\tO\nthat\tO\nrallied\tO\nthe\tO\nMilwaukee\tB-ORG\nBrewers\tI-ORG\nto\tO\na\tO\n10-7\tO\nvictory\tO\nover\tO\nthe\tO\nTwins\tB-ORG\n.\tO\n\nJaha\tB-PER\nadded\tO\nan\tO\nRBI\tB-MISC\nsingle\tO\nin\tO\nthe\tO\nninth\tO\nand\tO\nhad\tO\nfour\tO\nRBI\tB-MISC\n.\tO\n\nJose\tB-PER\nValentin\tI-PER\nhit\tO\nhis\tO\n21st\tO\nhomer\tO\nfor\tO\nMilwaukee\tB-ORG\n.\tO\n\nSOCCER\tO\n-\tO\nCOCU\tB-PER\nDOUBLE\tO\nEARNS\tO\nPSV\tB-ORG\n4-1\tO\nWIN\tO\n.\tO\n\nPhilip\tB-PER\nCocu\tI-PER\nscored\tO\ntwice\tO\nin\tO\nthe\tO\nsecond\tO\nhalf\tO\nto\tO\nspur\tO\nPSV\tB-ORG\nEindhoven\tI-ORG\nto\tO\na\tO\n4-1\tO\naway\tO\nwin\tO\nover\tO\nNEC\tB-ORG\nNijmegen\tI-ORG\nin\tO\nthe\tO\nDutch\tB-MISC\nfirst\tO\ndivision\tO\non\tO\nThursday\tO\n.\tO\n\nArthur\tB-PER\nNuman\tI-PER\nand\tO\nLuc\tB-PER\nNilis\tI-PER\n,\tO\nDutch\tB-MISC\ntop\tO\nscorer\tO\nlast\tO\nseason\tO\n,\tO\nwere\tO\nPSV\tB-ORG\n's\tO\nother\tO\nmarksmen\tO\n.\tO\n\nAjax\tB-ORG\nAmsterdam\tI-ORG\nopened\tO\ntheir\tO\ntitle\tO\ndefence\tO\nwith\tO\na\tO\n1-0\tO\nwin\tO\nover\tO\nNAC\tB-ORG\nBreda\tI-ORG\non\tO\nWednesday\tO\n.\tO\n\nSOCCER\tO\n-\tO\nDUTCH\tB-MISC\nFIRST\tO\nDIVISION\tO\nSUMMARY\tO\n.\tO\n\nDutch\tB-MISC\nfirst\tO\ndivision\tO\nmatch\tO\n:\tO\n\nNEC\tB-ORG\nNijmegen\tI-ORG\n1\tO\n(\tO\nVan\tO\nEykeren\tO\n15th\tO\n)\tO\nPSV\tB-ORG\nEindhoven\tI-ORG\n4\tO\n(\tO\nNuman\tO\n11th\tO\n,\tO\n\nNilis\tO\n42nd\tO\n,\tO\nCocu\tB-PER\n54th\tO\n,\tO\n67th\tO\n)\tO\n.\tO\n\nSOCCER\tO\n-\tO\nDUTCH\tB-MISC\nFIRST\tO\nDIVISION\tO\nRESULT\tO\n.\tO\n\nResult\tO\nof\tO\na\tO\nDutch\tB-MISC\nfirst\tO\n\nNEC\tB-ORG\nNijmegen\tI-ORG\n1\tO\nPSV\tO\nEindhoven\tO\n4\tO\n\nSOCCER\tO\n-\tO\nSHARPSHOOTER\tO\nKNUP\tB-PER\nBACK\tO\nIN\tO\nSWISS\tB-MISC\nSQUAD\tO\n.\tO\n\nGalatasaray\tB-ORG\nstriker\tO\nAdrian\tB-PER\nKnup\tI-PER\n,\tO\nscorer\tO\nof\tO\n26\tO\ngoals\tO\nin\tO\n45\tO\ninternationals\tO\n,\tO\nhas\tO\nbeen\tO\nrecalled\tO\nby\tO\nSwitzerland\tB-LOC\nfor\tO\nthe\tO\nWorld\tB-MISC\nCup\tI-MISC\nqualifier\tO\nagainst\tO\nAzerbaijan\tB-LOC\nin\tO\nBaku\tB-LOC\non\tO\nAugust\tO\n31\tO\n.\tO\n\nKnup\tB-PER\nwas\tO\noverlooked\tO\nby\tO\nArtur\tO\nJorge\tO\nfor\tO\nthe\tO\nEuropean\tB-MISC\nchampionship\tO\nfinals\tO\nearlier\tO\nthis\tO\nyear\tO\n.\tO\n\nBut\tO\nnew\tO\ncoach\tO\nRolf\tB-PER\nFringer\tI-PER\nis\tO\nclearly\tO\na\tO\nKnup\tB-PER\nfan\tO\nand\tO\nincluded\tO\nhim\tO\nin\tO\nhis\tO\n19-man\tO\nsquad\tO\non\tO\nThursday\tO\n.\tO\n\nSwitzerland\tB-LOC\nfailed\tO\nto\tO\nprogress\tO\nbeyond\tO\nthe\tO\nopening\tO\ngroup\tO\nphase\tO\nin\tO\nEuro\tB-MISC\n96\tI-MISC\n.\tO\n\nGoalkeepers\tO\n-\tO\nMarco\tO\nPascolo\tO\n(\tO\nCagliari\tB-ORG\n)\tO\n,\tO\nPascal\tB-PER\nZuberbuehler\tI-PER\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n.\tO\n\nDefenders\tO\n-\tO\nStephane\tB-PER\nHenchoz\tI-PER\n(\tO\nHamburg\tB-ORG\n)\tO\n,\tO\nMarc\tB-PER\nHottiger\tI-PER\n(\tO\nEverton\tB-ORG\n)\tO\n,\tO\nYvan\tB-PER\nQuentin\tI-PER\n(\tO\nSion\tB-ORG\n)\tO\n,\tO\nRamon\tB-PER\nVega\tI-PER\n(\tO\nCagliari\tB-ORG\n)\tO\nRaphael\tO\nWicky\tO\n(\tO\nSion\tB-ORG\n)\tO\n.\tO\n\nMidfielders\tO\n-\tO\nAlexandre\tB-PER\nComisetti\tI-PER\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n,\tO\nAntonio\tB-PER\nEsposito\tI-PER\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n,\tO\nSebastien\tB-PER\nFournier\tI-PER\n(\tO\nStuttgart\tB-LOC\n)\tO\n,\tO\nChristophe\tB-PER\nOhrel\tI-PER\n(\tO\nLausanne\tB-LOC\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tB-ORG\n)\tO\n,\tO\nDavid\tB-PER\nSesa\tI-PER\n(\tO\nServette\tB-ORG\n)\tO\n,\tO\nCiriaco\tB-PER\nSforza\tI-PER\n(\tO\nInter\tB-ORG\nMilan\tI-ORG\n)\tO\nMurat\tB-PER\nYakin\tI-PER\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n.\tO\n\nStrikers\tO\n-\tO\nKubilay\tB-PER\nTurkyilmaz\tI-PER\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n,\tO\nAdrian\tB-PER\nKnup\tI-PER\n(\tO\nGalatasaray\tB-ORG\n)\tO\n,\tO\nChristophe\tO\nBonvin\tO\n(\tO\nSion\tB-ORG\n)\tO\n,\tO\nStephane\tB-PER\nChapuisat\tI-PER\n(\tO\nBorussia\tB-ORG\nDortmund\tI-ORG\n)\tO\n.\tO\n\nSpectators\tO\nat\tO\nFriday\tO\n's\tO\nBrussels\tB-LOC\ngrand\tO\nprix\tO\nmeeting\tO\nhave\tO\nan\tO\nextra\tO\nincentive\tO\nto\tO\ncheer\tO\non\tO\nthe\tO\nathletes\tO\nto\tO\nworld\tO\nrecord\tO\nperformances\tO\n--\tO\na\tO\nfree\tO\nglass\tO\nof\tO\nbeer\tO\n.\tO\n\nA\tO\nBelgian\tB-MISC\nbrewery\tO\nhas\tO\noffered\tO\nto\tO\npay\tO\nfor\tO\na\tO\nfree\tO\nround\tO\nof\tO\ndrinks\tO\nfor\tO\nall\tO\nof\tO\nthe\tO\n40,000\tO\ncrowd\tO\nif\tO\na\tO\nworld\tO\nrecord\tO\ngoes\tO\nat\tO\nthe\tO\nmeeting\tO\n,\tO\norganisers\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nGOLF\tO\n-\tO\nGERMAN\tB-MISC\nOPEN\tI-MISC\nFIRST\tO\nROUND\tO\nSCORES\tO\n.\tO\n\nSTUTTGART\tB-LOC\n,\tO\nGermany\tO\n1996-08-22\tO\n\nscores\tO\nin\tO\nthe\tO\nGerman\tB-MISC\nOpen\tI-MISC\ngolf\tO\nchampionship\tO\non\tO\nThursday\tO\n(\tO\nBritain\tB-LOC\n\n64\tO\nDavid\tO\nJ.\tO\nRussell\tO\n,\tO\nMichael\tB-PER\nCampbell\tI-PER\n(\tO\nNew\tB-LOC\nZealand\tI-LOC\n)\tO\n,\tO\nIan\tB-PER\n\nWoosnam\tB-PER\n,\tO\nBernhard\tB-PER\nLanger\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\n,\tO\nRonan\tB-PER\nRafferty\tI-PER\n,\tO\nMats\tB-PER\n\nLanner\tB-PER\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nWayne\tB-PER\nRiley\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n\n65\tO\nEamonn\tO\nDarcy\tO\n(\tO\nIreland\tB-LOC\n)\tO\n,\tO\nPer\tB-PER\nNyman\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nRussell\tB-PER\nClaydon\tI-PER\n,\tO\n\nMark\tB-PER\nRoe\tI-PER\n,\tO\nRetief\tB-PER\nGoosen\tI-PER\n(\tO\nSouth\tO\nAfrica\tO\n)\tO\n,\tO\nCarl\tB-PER\nSuneson\tI-PER\n\n66\tO\nStephen\tB-PER\nField\tI-PER\n,\tO\nPaul\tB-PER\nLawrie\tI-PER\n,\tO\nIan\tB-PER\nPyman\tI-PER\n,\tO\nMax\tB-PER\nAnglert\tI-PER\n\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nMiles\tB-PER\nTunnicliff\tI-PER\n,\tO\nChristian\tO\nCevaer\tO\n(\tO\nFrance\tB-LOC\n)\tO\n,\tO\n\nDes\tB-PER\nSmyth\tI-PER\n(\tO\nIreland\tB-LOC\n)\tO\n,\tO\nDavid\tB-PER\nCarter\tI-PER\n,\tO\nLee\tB-PER\nWestwood\tI-PER\n,\tO\nGreg\tB-PER\n\nChalmers\tB-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n,\tO\nMiguel\tB-PER\nAngel\tI-PER\nMartin\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\n\nThomas\tB-PER\nBjorn\tI-PER\n(\tO\nDenmark\tB-LOC\n)\tO\n,\tO\nFernando\tO\nRoca\tO\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\nDerrick\tB-PER\n\n67\tO\nJeff\tB-PER\nHawksworth\tI-PER\n,\tO\nPadraig\tB-PER\nHarrington\tI-PER\n(\tO\nIreland\tB-LOC\n)\tO\n,\tO\nMichael\tO\n\nWelch\tB-PER\n,\tO\nThomas\tB-PER\nGogele\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\n,\tO\nPaul\tB-PER\nMcGinley\tI-PER\n(\tO\nIreland\tB-LOC\n)\tO\n,\tO\n\nGary\tB-PER\nOrr\tI-PER\n,\tO\nJose-Maria\tB-PER\nCanizares\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\nMichael\tB-PER\nJonzon\tI-PER\n\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nPaul\tO\nEales\tO\n,\tO\nDavid\tB-PER\nWilliams\tI-PER\n,\tO\nAndrew\tB-PER\nColtart\tI-PER\n,\tO\n\nJonathan\tB-PER\nLomas\tI-PER\n,\tO\nJose\tB-PER\nRivero\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\nRobert\tO\nKarlsson\tO\n\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nMarcus\tB-PER\nWills\tI-PER\n,\tO\nPedro\tB-PER\nLinhart\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\nJamie\tB-PER\n\nSpence\tB-PER\n,\tO\nTerry\tB-PER\nPrice\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n,\tO\nJuan\tB-PER\nCarlos\tI-PER\nPinero\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\n\nSOCCER\tO\n-\tO\nUEFA\tB-ORG\nREWARDS\tO\nTHREE\tO\nCOUNTRIES\tO\nFOR\tO\nFAIR\tO\nPLAY\tO\n.\tO\n\nNorway\tB-LOC\n,\tO\nEngland\tB-LOC\nand\tO\nSweden\tB-LOC\nwere\tO\nrewarded\tO\nfor\tO\ntheir\tO\nfair\tO\nplay\tO\non\tO\nThursday\tO\nwith\tO\nan\tO\nadditional\tO\nplace\tO\nin\tO\nthe\tO\n1997-98\tO\nUEFA\tO\nCup\tO\ncompetition\tO\n.\tO\n\nNorway\tB-LOC\nheaded\tO\nthe\tO\nUEFA\tB-MISC\nFair\tI-MISC\nPlay\tI-MISC\nrankings\tO\nfor\tO\n1995-96\tO\nwith\tO\n8.62\tO\npoints\tO\n,\tO\nahead\tO\nof\tO\nEngland\tB-LOC\nwith\tO\n8.61\tO\nand\tO\nSweden\tB-LOC\n8.57\tO\n.\tO\n\nNorway\tB-LOC\n8.62\tO\npoints\tO\n\n2.\tO\nEngland\tB-LOC\n8.61\tO\n\n3.\tO\nSweden\tB-LOC\n8.57\tO\n\n5.\tO\nWales\tB-LOC\n8.54\tO\n\n6.\tO\nEstonia\tB-LOC\n8.52\tO\n\n8.\tO\nBelarus\tB-LOC\n8.39\tO\n\n15.\tO\nMoldova\tB-LOC\n8.24\tO\n\n18.\tO\nLuxembourg\tB-LOC\n8.20\tO\n\n19.\tO\nFrance\tB-LOC\n8.18\tO\n\n20.\tO\nIsrael\tB-LOC\n8.17\tO\n\n25.\tO\nGeorgia\tB-LOC\n8.10\tO\n\n26.\tO\nUkraine\tB-LOC\n8.09\tO\n\n26.\tO\nSpain\tB-LOC\n8.09\tO\n\n26.\tO\nFinland\tB-LOC\n8.09\tO\n\n30.\tO\nLithuania\tB-LOC\n8.06\tO\n\n32.\tO\nRussia\tB-LOC\n8.03\tO\n\n36.\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n7.95\tO\n\n42.\tO\nSlovenia\tB-LOC\n7.77\tO\n\n43.\tO\nCroatia\tB-LOC\n7.75\tO\n\n45.\tO\nMalta\tB-LOC\n7.40\tO\n\nCRICKET\tO\n-\tO\nPOLICE\tO\nCOMMANDOS\tO\nON\tO\nHAND\tO\nFOR\tO\nAUSTRALIANS\tB-MISC\n'\tO\nFIRST\tO\nMATCH\tO\n.\tO\n\nArmed\tO\npolice\tO\ncommandos\tO\npatrolled\tO\nthe\tO\nground\tO\nwhen\tO\nAustralia\tB-LOC\nopened\tO\ntheir\tO\nshort\tO\ntour\tO\nof\tO\nSri\tB-LOC\nLanka\tI-LOC\nwith\tO\na\tO\nfive-run\tO\nwin\tO\nover\tO\nthe\tO\ncountry\tO\n's\tO\nyouth\tO\nteam\tO\non\tO\nThursday\tO\n.\tO\n\nAustralia\tB-LOC\n,\tO\nin\tO\nSri\tB-LOC\nLanka\tI-LOC\nfor\tO\na\tO\nlimited\tO\novers\tO\ntournament\tO\nwhich\tO\nalso\tO\nincludes\tO\nIndia\tB-LOC\nand\tO\nZimbabwe\tB-LOC\n,\tO\nhave\tO\nbeen\tO\npromised\tO\nthe\tO\npresence\tO\nof\tO\ncommandos\tO\n,\tO\nsniffer\tO\ndogs\tO\nand\tO\nplainclothes\tO\npolicemen\tO\nto\tO\nensure\tO\nthe\tO\ntournament\tO\nis\tO\ntrouble-free\tO\n.\tO\n\nThey\tO\nare\tO\nmaking\tO\ntheir\tO\nfirst\tO\nvisit\tO\nto\tO\nthe\tO\nisland\tO\nsince\tO\nboycotting\tO\na\tO\nWorld\tB-MISC\nCup\tI-MISC\nfixture\tO\nin\tO\nFebruary\tO\nbecause\tO\nof\tO\nfears\tO\nover\tO\nethnic\tO\nviolence\tO\n.\tO\n\nAustralia\tB-LOC\n,\tO\nbatting\tO\nfirst\tO\nin\tO\nThursday\tO\n's\tO\nthe\tO\nwarm-up\tO\nmatch\tO\n,\tO\nscored\tO\n251\tO\nfor\tO\nseven\tO\nfrom\tO\ntheir\tO\n50\tO\novers\tO\n.\tO\n\nRicky\tB-PER\nPonting\tI-PER\nled\tO\nthe\tO\nway\tO\nwith\tO\n100\tO\noff\tO\n119\tO\nballs\tO\nwith\tO\ntwo\tO\nsixes\tO\nand\tO\nnine\tO\nfours\tO\nbefore\tO\nretiring\tO\n.\tO\n\nAustralian\tB-MISC\ncoach\tO\nGeoff\tB-PER\nMarsh\tI-PER\nsaid\tO\nhe\tO\nwas\tO\nimpressed\tO\nwith\tO\nthe\tO\ncompetitiveness\tO\nof\tO\nthe\tO\nopposition\tO\n.\tO\n\nONE\tO\nROMANIAN\tB-MISC\nDIES\tO\nIN\tO\nBUS\tO\nCRASH\tO\nIN\tO\nBULGARIA\tB-LOC\n.\tO\n\nOne\tO\nRomanian\tB-MISC\npassenger\tO\nwas\tO\nkilled\tO\n,\tO\nand\tO\n14\tO\nothers\tO\nwere\tO\ninjured\tO\non\tO\nThursday\tO\nwhen\tO\na\tO\nRomanian-registered\tB-MISC\nbus\tO\ncollided\tO\nwith\tO\na\tO\nBulgarian\tB-MISC\none\tO\nin\tO\nnorthern\tO\nBulgaria\tB-LOC\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nThe\tO\ntwo\tO\nbuses\tO\ncollided\tO\nhead\tO\non\tO\nat\tO\n5\tO\no'clock\tO\nthis\tO\nmorning\tO\non\tO\nthe\tO\nroad\tO\nbetween\tO\nthe\tO\ntowns\tO\nof\tO\nRousse\tO\nand\tO\nVeliko\tB-LOC\nTarnovo\tI-LOC\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nA\tO\nRomanian\tB-MISC\nwoman\tO\nMaria\tB-PER\nMarco\tI-PER\n,\tO\n35\tO\n,\tO\nwas\tO\nkilled\tO\n.\tO\n\nOFFICIAL\tB-ORG\nJOURNAL\tI-ORG\nCONTENTS\tO\n-\tO\nOJ\tB-ORG\nL\tO\n211\tO\nOF\tO\nAUGUST\tO\n21\tO\n,\tO\n1996\tO\n.\tO\n\n(\tO\nNote\tO\n-\tO\ncontents\tO\nare\tO\ndisplayed\tO\nin\tO\nreverse\tO\norder\tO\nto\tO\nthat\tO\nin\tO\nthe\tO\nprinted\tO\nJournal\tB-ORG\n)\tO\n\nCorrigendum\tO\nto\tO\nCommission\tB-MISC\nRegulation\tI-MISC\n(\tO\nEC\tB-ORG\n)\tO\nNo\tO\n1464/96\tO\nof\tO\n25\tO\nJuly\tO\n1996\tO\nrelating\tO\nto\tO\na\tO\nstanding\tO\ninvitation\tO\nto\tO\ntender\tO\nto\tO\ndetermine\tO\nlevies\tO\nand\tO\n/\tO\nor\tO\nrefunds\tO\non\tO\nexports\tO\nof\tO\nwhite\tO\nsugar\tO\n(\tO\nOJ\tO\nNo\tO\nL\tO\n187\tO\nof\tO\n26.7.1996\tO\n)\tO\n\nCorrigendum\tO\nto\tO\nCommission\tB-MISC\nRegulation\tI-MISC\n(\tO\nEC\tB-ORG\n)\tO\nNo\tO\n658/96\tO\nof\tO\n9\tO\nApril\tO\n1996\tO\non\tO\ncertain\tO\nconditions\tO\nfor\tO\ngranting\tO\ncompensatory\tO\npayments\tO\nunder\tO\nthe\tO\nsupport\tO\nsystem\tO\nfor\tO\nproducers\tO\nof\tO\ncertain\tO\narable\tO\ncrops\tO\n(\tO\nOJ\tB-ORG\nNo\tO\nL\tO\n91\tO\nof\tO\n12.4.1996\tO\n)\tO\n\nCommission\tB-MISC\nRegulation\tI-MISC\n(\tO\nEC\tB-ORG\n)\tO\nNo\tO\n1663/96\tO\nof\tO\n20\tO\nAugust\tO\n1996\tO\nestablishing\tO\nthe\tO\nstandard\tO\nimport\tO\nvalues\tO\nfor\tO\ndetermining\tO\nthe\tO\nentry\tO\nprice\tO\nof\tO\ncertain\tO\nfruit\tO\nand\tO\nvegetables\tO\nEND\tO\nOF\tO\nDOCUMENT\tO\n.\tO\n\nIn\tB-ORG\nHome\tI-ORG\nHealth\tI-ORG\nto\tO\nappeal\tO\npayment\tO\ndenial\tO\n.\tO\n\nMINNETONKA\tB-LOC\n,\tO\nMinn\tO\n.\tO\n\nIn\tB-ORG\nHome\tI-ORG\nHealth\tI-ORG\nInc\tI-ORG\nsaid\tO\non\tO\nThursday\tO\nit\tO\nwill\tO\nappeal\tO\nto\tO\nthe\tO\nU.S.\tB-ORG\nFederal\tI-ORG\nDistrict\tI-ORG\nCourt\tI-ORG\nin\tO\nMinneapolis\tB-LOC\na\tO\ndecision\tO\nby\tO\nthe\tO\nHealth\tB-ORG\nCare\tI-ORG\nFinancing\tI-ORG\nAdministration\tI-ORG\n(\tO\nHCFA\tB-ORG\n)\tO\nthat\tO\ndenied\tO\nreimbursement\tO\nof\tO\ncertain\tO\ncosts\tO\nunder\tO\nMedicaid\tB-MISC\n.\tO\n\nThe\tO\nHCFA\tB-ORG\nAdministrator\tO\nreversed\tO\na\tO\npreviously\tO\nfavorable\tO\ndecision\tO\nregarding\tO\nthe\tO\nreimbursement\tO\nof\tO\ncosts\tO\nrelated\tO\nto\tO\nthe\tO\ncompany\tO\n's\tO\ncommunity\tO\nliaison\tO\npersonnel\tO\n,\tO\nit\tO\nadded\tO\n.\tO\n\nThe\tO\ncompany\tO\nsaid\tO\nit\tO\ncontinues\tO\nto\tO\nbelieve\tO\nthe\tO\nmajority\tO\nof\tO\nthe\tO\ncommunity\tO\nliaison\tO\ncosts\tO\nare\tO\ncoverable\tO\nunder\tO\nthe\tO\nterms\tO\nof\tO\nthe\tO\nMedicare\tB-MISC\nprogram\tO\n.\tO\n\n\"\tO\nWe\tO\nare\tO\ndisappointed\tO\nwith\tO\nthe\tO\nadministrator\tO\n's\tO\ndecision\tO\nbut\tO\nwe\tO\ncontinue\tO\nto\tO\nbe\tO\noptimistic\tO\nregarding\tO\nan\tO\nultimate\tO\nfavorable\tO\nresolution\tO\n,\tO\n\"\tO\nMark\tB-PER\nGildea\tI-PER\n,\tO\nchief\tO\nexecutive\tO\nofficer\tO\n,\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\n.\tO\n\nIn\tB-ORG\nHome\tI-ORG\nHealth\tI-ORG\nsaid\tO\nit\tO\npreviously\tO\nrecorded\tO\na\tO\nreserve\tO\nequal\tO\nto\tO\n16\tO\npercent\tO\nof\tO\nall\tO\nrevenue\tO\nrelated\tO\nto\tO\nthe\tO\ncommunity\tO\nliaison\tO\ncosts\tO\n.\tO\n\nSeparately\tO\n,\tO\nIn\tB-ORG\nHome\tI-ORG\nHealth\tI-ORG\nsaid\tO\nthe\tO\nU.S.\tB-ORG\nDistrict\tI-ORG\nCourt\tI-ORG\nin\tO\nMinneapolis\tB-LOC\nruled\tO\nin\tO\nits\tO\nfavor\tO\nregarding\tO\nthe\tO\nreimbursement\tO\nof\tO\ncertain\tO\ninterest\tO\nexpenses\tO\n.\tO\n\nThis\tO\ndecision\tO\nwill\tO\nresult\tO\nin\tO\nthe\tO\nreimbursement\tO\nby\tO\nMedicare\tB-MISC\nof\tO\n$\tO\n81,000\tO\nin\tO\ndisputed\tO\ncosts\tO\n.\tO\n\n\"\tO\nThis\tO\nis\tO\nour\tO\nfirst\tO\ndecision\tO\nin\tO\nfederal\tO\ndistrct\tO\ncourt\tO\nregarding\tO\na\tO\ndispute\tO\nwith\tO\nMedicare\tB-MISC\n,\tO\n\"\tO\nGildea\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\nWe\tO\nare\tO\nextremely\tO\npleased\tO\nwith\tO\nthis\tO\ndecision\tO\nand\tO\nwe\tO\nrecognize\tO\nit\tO\nas\tO\na\tO\nsignificant\tO\nstep\tO\ntoward\tO\nresolution\tO\nof\tO\nour\tO\noutstanding\tO\nMedicare\tB-MISC\ndisputes\tO\n.\tO\n\"\tO\n\n--\tO\nChicago\tB-ORG\nNewsdesk\tI-ORG\n312-408-8787\tO\n\nOppenheimer\tB-ORG\nCapital\tI-ORG\nLP\tI-ORG\nsaid\tO\non\tO\nThursday\tO\nit\tO\nwill\tO\nreview\tO\nits\tO\ncash\tO\ndistribution\tO\nrate\tO\nfor\tO\nthe\tO\nOctober\tO\nquarterly\tO\ndistribution\tO\n,\tO\nassuming\tO\ncontinued\tO\nfavorable\tO\nresults\tO\n.\tO\n\nBest\tB-ORG\nsees\tO\nQ2\tO\nloss\tO\nsimilar\tO\nto\tO\nQ1\tO\nloss\tO\n.\tO\n\nRICHMOND\tB-LOC\n,\tO\nVa\tO\n.\tO\n\nBest\tB-ORG\nProducts\tI-ORG\nCo\tI-ORG\nChairman\tO\nand\tO\nChief\tO\nExecutive\tO\nDaniel\tB-PER\nLevy\tI-PER\nsaid\tO\nThursday\tO\nhe\tO\nexpected\tO\nthe\tO\ncompany\tO\n's\tO\nsecond-quarter\tO\nresults\tO\nto\tO\nbe\tO\nsimilar\tO\nto\tO\nthe\tO\n$\tO\n34.6\tO\nmillion\tO\nloss\tO\nposted\tO\nin\tO\nthe\tO\nfirst\tO\nquarter\tO\n.\tO\n\nHe\tO\nalso\tO\ntold\tO\nReuters\tB-ORG\nbefore\tO\nthe\tO\nretailer\tO\n's\tO\nannual\tO\nmeeting\tO\nthat\tO\nthe\tO\nsecond\tO\nquarter\tO\ncould\tO\nbe\tO\nbetter\tO\nthan\tO\nthe\tO\nfirst\tO\nquarter\tO\nended\tO\nMay\tO\n4\tO\n.\tO\n\"\tO\n\nLevy\tB-PER\nsaid\tO\nseeking\tO\nbankruptcy\tO\nprotection\tO\nwas\tO\nnot\tO\nunder\tO\nconsideration\tO\n.\tO\n\nBest\tB-ORG\nemerged\tO\nfrom\tO\nChapter\tB-MISC\n11\tI-MISC\nbankruptcy\tO\nprotection\tO\nin\tO\nJune\tO\n1994\tO\nafter\tO\n3-1/2\tO\nyears\tO\n.\tO\n\n\"\tO\nBankruptcy\tO\nis\tO\nalways\tO\npossible\tO\n,\tO\nparticularly\tO\nwhen\tO\nyou\tO\nlose\tO\nwhat\tO\nwe\tO\nare\tO\ngoing\tO\nto\tO\nlose\tO\nin\tO\nthe\tO\nfirst\tO\nhalf\tO\nof\tO\nthis\tO\nyear\tO\n,\tO\n\"\tO\nLevy\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\nThe\tO\nRichmond-based\tB-MISC\nretailer\tO\nlost\tO\n$\tO\n95.7\tO\nmillion\tO\nin\tO\nthe\tO\nfiscal\tO\nyear\tO\nended\tO\nFebruary\tO\n3\tO\n.\tO\n\nLevy\tB-PER\nsaid\tO\nthat\tO\nBest\tB-ORG\nplanned\tO\nto\tO\nopen\tO\ntwo\tO\nnew\tO\nstores\tO\nthis\tO\nfall\tO\n.\tO\n\nAt\tO\nthe\tO\ntime\tO\n,\tO\nBest\tB-ORG\nsaid\tO\nit\tO\ndid\tO\nnot\tO\nplan\tO\nto\tO\nopen\tO\nany\tO\nnew\tO\nstores\tO\nthis\tO\nfall\tO\n.\tO\n\nFor\tO\nlast\tO\nyear\tO\n's\tO\nsecond\tO\nquarter\tO\n,\tO\nwhich\tO\nended\tO\nJuly\tO\n29\tO\n,\tO\n1995\tO\n,\tO\nBest\tB-ORG\nposted\tO\na\tO\nloss\tO\nof\tO\n$\tO\n7.1\tO\nmillion\tO\n,\tO\nor\tO\n$\tO\n0.23\tO\nper\tO\nshare\tO\n,\tO\non\tO\nsales\tO\nof\tO\n$\tO\n311.9\tO\nmillion\tO\n.\tO\n\nWomen\tO\nwho\tO\nget\tO\nmeasles\tO\nwhile\tO\npregnant\tO\nmay\tO\nhave\tO\nbabies\tO\nat\tO\nhigher\tO\nrisk\tO\nof\tO\nCrohn\tB-PER\n's\tO\ndisease\tO\n,\tO\na\tO\ndebilitating\tO\nbowel\tO\ndisorder\tO\n,\tO\nresearchers\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nThree\tO\nout\tO\nof\tO\nfour\tO\nSwedish\tB-MISC\nbabies\tO\nborn\tO\nto\tO\nmothers\tO\nwho\tO\ncaught\tO\nmeasles\tO\ndeveloped\tO\nserious\tO\ncases\tO\nof\tO\nCrohn\tB-PER\n's\tO\ndisease\tO\n,\tO\nthe\tO\nresearchers\tO\nsaid\tO\n.\tO\n\nDr\tO\nAndrew\tB-PER\nWakefield\tI-PER\nof\tO\nthe\tO\nRoyal\tB-LOC\nFree\tI-LOC\nHospital\tI-LOC\nSchool\tI-LOC\nof\tI-LOC\nMedicine\tI-LOC\nand\tO\ncolleagues\tO\nscreened\tO\n25,000\tO\nbabies\tO\ndelivered\tO\nat\tO\nUniversity\tB-LOC\nHospital\tI-LOC\n,\tO\nUppsala\tB-LOC\n,\tO\nbetween\tO\n1940\tO\nand\tO\n1949\tO\n.\tO\n\n\"\tO\nThree\tO\nof\tO\nthe\tO\nfour\tO\nchildren\tO\nhad\tO\nCrohn\tB-PER\n's\tO\ndisease\tO\n,\tO\n\"\tO\nWakefield\tB-PER\n's\tO\ngroup\tO\nwrote\tO\nin\tO\nthe\tO\nLancet\tB-ORG\nmedical\tO\njournal\tO\n.\tO\n\nCrohn\tB-PER\n's\tO\nis\tO\nan\tO\ninflammation\tO\nof\tO\nthe\tO\nbowel\tO\nthat\tO\ncan\tO\nsometimes\tO\nrequire\tO\nsurgery\tO\n.\tO\n\nMost\tO\nnotably\tO\n,\tO\nwomen\tO\nwho\tO\nget\tO\nrubella\tO\n(\tO\nGerman\tB-MISC\nmeasles\tO\n)\tO\nhave\tO\na\tO\nhigh\tO\nrisk\tO\nof\tO\na\tO\nstillborn\tO\nbaby\tO\n.\tO\n\nAll\tO\nthe\tO\nkey\tO\nnumbers\tO\n-\tO\nCBI\tB-ORG\nAugust\tO\nindustrial\tO\ntrends\tO\n.\tO\n\nFollowing\tO\nare\tO\nkey\tO\ndata\tO\nfrom\tO\nthe\tO\nAugust\tO\nmonthly\tO\nsurvey\tO\nof\tO\ntrends\tO\nin\tO\nUK\tB-LOC\nmanufacturing\tO\nby\tO\nthe\tO\nConfederation\tB-ORG\nof\tI-ORG\nBritish\tI-ORG\nIndustry\tI-ORG\n(\tO\nCBI\tB-ORG\n)\tO\n.\tO\n\nCBI\tB-ORG\nMONTHLY\tO\nTRENDS\tO\nENQUIRY\tO\n(\tO\na\tO\n)\tO\nAUG\tO\nJULY\tO\nJUNE\tO\nMAY\tO\n\nThe\tO\nsurvey\tO\nwas\tO\nconducted\tO\nbetween\tO\nJuly\tO\n23\tO\nand\tO\nAugust\tO\n14\tO\nand\tO\ninvolved\tO\n1,305\tO\ncompanies\tO\n,\tO\nrepresenting\tO\n50\tO\nindustries\tO\n,\tO\naccounting\tO\nfor\tO\naround\tO\nhalf\tO\nof\tO\nthe\tO\nUK\tB-LOC\n's\tO\nmanufactured\tO\nexports\tO\nand\tO\nsome\tO\ntwo\tO\nmillion\tO\nemployees\tO\n.\tO\n\n--\tO\nRosemary\tB-PER\nBennett\tI-PER\n,\tO\nLondon\tB-ORG\nNewsroom\tI-ORG\n+44\tO\n171\tO\n542\tO\n7715\tO\n\nIron\tB-MISC\nGippsland\tI-MISC\n-\tO\n(\tO\nbuilt\tO\n1989\tO\n)\tO\n87,241\tO\ndwt\tO\nsold\tO\nto\tO\nGreek\tB-MISC\nbuyers\tO\nfor\tO\n$\tO\n30\tO\nmillion\tO\n.\tO\n\nSairyu\tB-MISC\nMaru\tI-MISC\nNo\tI-MISC\n:\tI-MISC\n2\tI-MISC\n-\tO\n(\tO\nbuilt\tO\n1982\tO\n)\tO\n60,960\tO\ndwt\tO\nsold\tO\nto\tO\nGreek\tB-MISC\nbuyers\tO\nfor\tO\n$\tO\n15.5\tO\nmillion\tO\n.\tO\n\nStainless\tB-MISC\nFighter\tI-MISC\n-\tO\n(\tO\nbuilt\tO\n1970\tO\n)\tO\n21,718\tO\ndwt\tO\nsold\tO\nat\tO\nauction\tO\nfor\tO\n$\tO\n6\tO\nmillion\tO\n.\tO\n\nGarlic\tO\npills\tO\nmay\tO\nnot\tO\nlower\tO\nblood\tO\ncholesterol\tO\nand\tO\nstudies\tO\nthat\tO\nshow\tO\nthey\tO\ndo\tO\nmay\tO\nbe\tO\nflawed\tO\n,\tO\nBritish\tB-MISC\nresearchers\tO\nhave\tO\nreported\tO\n.\tO\n\nA\tO\nstudy\tO\nby\tO\na\tO\nteam\tO\nof\tO\ndoctors\tO\nat\tO\nOxford\tB-ORG\nUniversity\tI-ORG\nhas\tO\nfound\tO\npeople\tO\nwith\tO\nhigh\tO\nblood\tO\ncholesterol\tO\ndo\tO\nnot\tO\nbenefit\tO\nsignificantly\tO\nfrom\tO\ntaking\tO\ngarlic\tO\ntablets\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nsignificant\tO\ndifferences\tO\nbetween\tO\nthe\tO\ngroups\tO\nreceiving\tO\ngarlic\tO\nand\tO\nplacebo\tO\n,\tO\n\"\tO\nthey\tO\nwrote\tO\nin\tO\nthe\tO\nJournal\tB-ORG\nof\tI-ORG\nthe\tI-ORG\nRoyal\tI-ORG\nCollege\tI-ORG\nof\tI-ORG\nPhysicians\tI-ORG\n.\tO\n\nBut\tO\nthe\tO\nOxford\tB-LOC\nteam\tO\ndisputed\tO\nthese\tO\nfindings\tO\nand\tO\nsaid\tO\neither\tO\nprevious\tO\ntrials\tO\nmay\tO\nhave\tO\nbeen\tO\ninterpreted\tO\nincorrectly\tO\n,\tO\nthose\tO\ntaking\tO\npart\tO\nwere\tO\nnot\tO\ngiven\tO\nspecial\tO\ndiets\tO\nbeforehand\tO\nor\tO\nthe\tO\nduration\tO\nof\tO\nthe\tO\nstudies\tO\nmay\tO\nhave\tO\nbeen\tO\ntoo\tO\nshort\tO\n.\tO\n\nThe\tO\nsix-month\tO\ntrial\tO\nwas\tO\nfunded\tO\nby\tO\nthe\tO\nBritish\tB-ORG\nHeart\tI-ORG\nFoundation\tI-ORG\nand\tO\nLichtwer\tB-ORG\nPharma\tI-ORG\nGmbH\tI-ORG\n,\tO\nwhich\tO\nmakes\tO\nKwai\tB-MISC\nbrand\tO\ngarlic\tO\ntablets\tO\n.\tO\n\nBritain\tB-LOC\ngives\tO\naid\tO\nto\tO\nvolcano-hit\tO\nCaribbean\tB-LOC\nisland\tO\n.\tO\n\nBritain\tB-LOC\nsaid\tO\non\tO\nThursday\tO\nit\tO\nwould\tO\ngive\tO\n25\tO\nmillion\tO\npounds\tO\n(\tO\n$\tO\n39\tO\nmillion\tO\n)\tO\nof\tO\ndevelopment\tO\naid\tO\nto\tO\nthe\tO\nCaribbean\tB-LOC\nisland\tO\nof\tO\nMontserrat\tB-LOC\n,\tO\nwhere\tO\nmuch\tO\nof\tO\nthe\tO\npopulation\tO\nliving\tO\nin\tO\nthe\tO\nsouth\tO\nhas\tO\nfled\tO\nto\tO\navoid\tO\na\tO\nvolcano\tO\n.\tO\n\nThe\tO\nvolcano\tO\nin\tO\nthe\tO\nSoufriere\tO\nhills\tO\nhas\tO\nerupted\tO\nthree\tO\ntimes\tO\nin\tO\nthe\tO\npast\tO\n13\tO\nmonths\tO\nand\tO\nlast\tO\nApril\tO\nsome\tO\n4,500\tO\npeople\tO\nliving\tO\nin\tO\nthe\tO\ncapital\tO\n,\tO\nPlymouth\tB-ORG\n,\tO\nand\tO\nsouthern\tO\nareas\tO\nwere\tO\nevacuated\tO\nto\tO\nthe\tO\nnorth\tO\n,\tO\nwhere\tO\nmany\tO\nare\tO\nliving\tO\nin\tO\npublic\tO\nshelters\tO\nand\tO\nschools\tO\n.\tO\n\n\"\tO\nThis\tO\nassistance\tO\nwill\tO\nprovide\tO\na\tO\nfast\tO\ntrack\tO\ndevelopment\tO\nprogramme\tO\nfor\tO\nthe\tO\ndesignated\tO\n(\tO\nnorthern\tO\n)\tO\nsafe\tO\narea\tO\n,\tO\n\"\tO\nBritain\tB-LOC\n's\tO\nOverseas\tB-ORG\nDevelopment\tI-ORG\nAdministration\tI-ORG\nsaid\tO\nin\tO\na\tO\nstatement\tO\n.\tO\n\nBritain\tB-LOC\ngave\tO\n8.5\tO\nmillion\tO\npounds\tO\n(\tO\n$\tO\n13\tO\nmillion\tO\n)\tO\nto\tO\nMontserrat\tB-LOC\n,\tO\nwhich\tO\nis\tO\none\tO\nof\tO\nits\tO\ndependent\tO\nterritories\tO\n,\tO\nwhen\tO\nthe\tO\nvolcano\tO\nfirst\tO\nbecame\tO\nactive\tO\n.\tO\n\nOverseas\tO\nDevelopment\tO\nMinister\tO\nLynda\tB-PER\nChalker\tI-PER\nsaid\tO\na\tO\nrecent\tO\ncensus\tO\nhad\tO\nshown\tO\nmost\tO\nMontserratians\tB-MISC\nwanted\tO\nto\tO\nremain\tO\non\tO\nthe\tO\nisland\tO\n.\tO\n\"\tO\n\nTennis\tO\n-\tO\nPhilippoussis\tB-PER\nlooms\tO\nfor\tO\nSampras\tB-PER\nin\tO\nU.S.\tB-MISC\nOpen\tI-MISC\n.\tO\n\nWorld\tO\nnumber\tO\none\tO\nPete\tB-PER\nSampras\tI-PER\n,\tO\nseeking\tO\nhis\tO\nfirst\tO\nGrand\tB-MISC\nSlam\tI-MISC\ntitle\tO\nof\tO\nthe\tO\nyear\tO\n,\tO\nand\tO\nwomen\tO\n's\tO\ntop\tO\nseed\tO\nSteffi\tB-PER\nGraf\tI-PER\n,\tO\naiming\tO\nfor\tO\nher\tO\nthird\tO\n,\tO\nshould\tO\nbe\tO\nable\tO\nto\tO\nease\tO\ninto\tO\nthe\tO\nyear\tO\n's\tO\nfinal\tO\nmajor\tO\n,\tO\nwhich\tO\nbegins\tO\non\tO\nMonday\tO\n.\tO\n\nSampras\tB-PER\nopens\tO\nthe\tO\ndefence\tO\nof\tO\nhis\tO\nU.S.\tB-MISC\nOpen\tI-MISC\ncrown\tO\nagainst\tO\nDavid\tB-PER\nRikl\tI-PER\nof\tO\nthe\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n,\tO\nwhile\tO\ntop-ranked\tO\nGraf\tB-PER\nbegins\tO\nher\tO\ntitle\tO\ndefence\tO\nagainst\tO\nYayuk\tB-PER\nBasuki\tI-PER\nof\tO\nIndonesia\tB-LOC\n.\tO\n\nWednesday\tO\n's\tO\nU.S.\tB-MISC\nOpen\tI-MISC\ndraw\tO\nceremony\tO\nrevealed\tO\nthat\tO\nboth\tO\ntitle\tO\nholders\tO\nshould\tO\nrun\tO\ninto\tO\ntheir\tO\nfirst\tO\nserious\tO\nopposition\tO\nin\tO\nthe\tO\nthird\tO\nround\tO\n.\tO\n\nLooming\tO\nin\tO\nSampras\tB-PER\n's\tO\nfuture\tO\nis\tO\na\tO\nlikely\tO\nthird-round\tO\ndate\tO\nwith\tO\nrecent\tO\nnemesis\tO\nMark\tB-PER\nPhilippoussis\tI-PER\n,\tO\nthe\tO\nrising\tO\nAustralian\tB-MISC\nwho\tO\ntook\tO\nout\tO\nSampras\tB-PER\nin\tO\nthe\tO\nthird\tO\nround\tO\nof\tO\nthe\tO\nAustralian\tB-MISC\nOpen\tI-MISC\nin\tO\nJanuary\tO\n.\tO\n\nSampras\tB-PER\navenged\tO\nthat\tO\ndefeat\tO\nwith\tO\na\tO\nstraight\tO\nsets\tO\nwin\tO\nover\tO\nthe\tO\n19-year-old\tO\npower\tO\nhitter\tO\nin\tO\nthe\tO\nsecond\tO\nround\tO\nat\tO\nWimbledon\tB-LOC\nand\tO\ntheir\tO\nrubber\tO\nmatch\tO\nin\tO\nNew\tB-LOC\nYork\tI-LOC\ncould\tO\nprovide\tO\nsome\tO\nfirst-week\tO\nfireworks\tO\n.\tO\n\nWhile\tO\nonly\tO\na\tO\nstunning\tO\nupset\tO\nwill\tO\nkeep\tO\nGraf\tO\nfrom\tO\nsailing\tO\nthrough\tO\nto\tO\na\tO\npredictable\tO\nsemifinal\tO\nshowdown\tO\nwith\tO\nthird\tO\nseed\tO\nArantxa\tB-PER\nSanchez\tI-PER\nVicario\tI-PER\n,\tO\nthe\tO\nGerman\tB-MISC\nstar\tO\ncould\tO\nalso\tO\nbe\tO\ntested\tO\nin\tO\nthe\tO\nthird\tO\nround\tO\nwhere\tO\nshe\tO\nwill\tO\nprobably\tO\nface\tO\n28th-ranked\tO\nveteran\tO\nNatasha\tO\nZvereva\tO\nof\tO\nBelarus\tB-LOC\n.\tO\n\nThere\tO\nwill\tO\nbe\tO\nno\tO\nrepeat\tO\nof\tO\nlast\tO\nyear\tO\n's\tO\nmen\tO\n's\tO\nfinal\tO\nwith\tO\neighth-ranked\tO\nAndre\tB-PER\nAgassi\tI-PER\nlanding\tO\nin\tO\nSampras\tB-PER\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nBumping\tO\nAgassi\tB-PER\nup\tO\nto\tO\nthe\tO\nsixth\tO\nseeding\tO\navoided\tO\nthe\tO\npossibility\tO\nthat\tO\nhe\tO\nwould\tO\nrun\tO\ninto\tO\nSampras\tB-PER\nas\tO\nearly\tO\nas\tO\nthe\tO\nquarter-finals\tO\n,\tO\nbut\tO\nthey\tO\ncould\tO\nlock\tO\nhorns\tO\nin\tO\nthe\tO\nsemis\tO\n.\tO\n\nOlympic\tB-MISC\nchampion\tO\nAgassi\tB-PER\nmeets\tO\nKarim\tB-PER\nAlami\tI-PER\nof\tO\nMorocco\tB-LOC\nin\tO\nthe\tO\nfirst\tO\nround\tO\n.\tO\n\nSurprise\tO\nsecond\tO\nseed\tO\nMichael\tB-PER\nChang\tI-PER\n,\tO\nranked\tO\nthird\tO\nin\tO\nthe\tO\nworld\tO\n,\tO\nopens\tO\nagainst\tO\nCzech\tB-MISC\nDaniel\tB-PER\nVacek\tI-PER\n,\tO\nwhile\tO\nwomen\tO\n's\tO\nsecond\tO\nseed\tO\nMonica\tB-PER\nSeles\tI-PER\ndrew\tO\nAmerican\tB-MISC\nAnne\tB-PER\nMiller\tI-PER\nas\tO\nher\tO\nfirst\tO\nvictim\tO\n.\tO\n\nSecond-ranked\tO\nAustrian\tO\nThomas\tB-PER\nMuster\tI-PER\n,\tO\nwho\tO\nwas\tO\nseeded\tO\nthird\tO\n,\tO\ndid\tO\nnot\tO\nhave\tO\nthe\tO\nluck\tO\nof\tO\nthe\tO\ndraw\tO\nwith\tO\nhim\tO\n.\tO\n\nIn\tO\nthe\tO\nfirst\tO\nround\tO\nMuster\tB-PER\nfaces\tO\nAmerican\tB-MISC\nRichey\tB-PER\nReneberg\tI-PER\n,\tO\nwho\tO\nhas\tO\nbeen\tO\nplaying\tO\nsome\tO\nof\tO\nthe\tO\nbest\tO\ntennis\tO\nof\tO\nhis\tO\ncareer\tO\nof\tO\nlate\tO\n.\tO\n\nIf\tO\nhe\tO\nsurvives\tO\n,\tO\nMuster\tB-PER\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\neither\tO\nfifth-seeded\tO\nWimbledon\tB-MISC\nchampion\tO\nRichard\tB-PER\nKrajicek\tI-PER\nof\tO\nthe\tO\nNetherlands\tB-LOC\nor\tO\n12th-seeded\tO\nAmerican\tB-MISC\nTodd\tB-PER\nMartin\tI-PER\nin\tO\nthe\tO\nquarter-finals\tO\nin\tO\nChang\tB-PER\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nPerhaps\tO\nthe\tO\nbest\tO\n,\tO\nyet\tO\nmost\tO\nunfortunate\tO\n,\tO\nfirst-round\tO\nmatchup\tO\nof\tO\nthe\tO\nmen\tO\n's\tO\ncompetition\tO\npits\tO\neighth\tO\nseed\tO\nJim\tB-PER\nCourier\tI-PER\nagainst\tO\nretiring\tO\nstar\tO\nStefan\tB-PER\nEdberg\tI-PER\n.\tO\n\nThe\tO\npopular\tO\nSwede\tB-MISC\nis\tO\nplaying\tO\nhis\tO\nfinal\tO\nmajor\tO\ntournament\tO\nnext\tO\nweek\tO\nand\tO\nthe\tO\ntwo-time\tO\nchampion\tO\n's\tO\nGrand\tB-MISC\nSlam\tI-MISC\nfarewell\tO\ncould\tO\nwell\tO\nbe\tO\na\tO\none-match\tO\naffair\tO\n.\tO\n\nWith\tO\nthe\tO\nexception\tO\nof\tO\na\tO\nPhilippoussis\tB-PER\nshowdown\tO\n,\tO\nSampras\tB-PER\nlooks\tO\nto\tO\nhave\tO\nlanded\tO\nin\tO\na\tO\ncomfortable\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nwith\tO\nthe\tO\nlikes\tO\nof\tO\nFrenchman\tB-MISC\nCedric\tB-PER\nPioline\tI-PER\nand\tO\nailing\tO\nFrench\tB-MISC\nOpen\tI-MISC\nchampion\tO\nYevgeny\tB-PER\nKafelnikov\tI-PER\n,\tO\nwho\tO\nis\tO\nnursing\tO\na\tO\nrib\tO\ninjury\tO\n,\tO\nin\tO\nhis\tO\npath\tO\n.\tO\n\nSeles\tB-PER\n,\tO\nrunner-up\tO\nto\tO\nGraf\tB-PER\nlast\tO\nyear\tO\n,\tO\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\nfifth-ranked\tO\nGerman\tB-MISC\nAnke\tB-PER\nHuber\tI-PER\nin\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nfourth\tO\nseed\tO\nConchita\tB-PER\nMartinez\tI-PER\nor\tO\neighth-seeded\tO\nOlympic\tB-MISC\nchampion\tO\nLindsay\tB-PER\nDavenport\tI-PER\nlooking\tO\nlike\tO\nher\tO\nmost\tO\nlikely\tO\nsemifinal\tO\nopponents\tO\n.\tO\n\nBut\tO\nHuber\tB-PER\nwill\tO\nbe\tO\ntested\tO\nimmediately\tO\nwith\tO\na\tO\nfirst-round\tO\nencounter\tO\nagainst\tO\ndangerous\tO\n18th-ranked\tO\nSouth\tB-MISC\nAfrican\tI-MISC\nAmanda\tB-PER\nCoetzer\tI-PER\n.\tO\n\nSanchez\tB-PER\nVicario\tI-PER\n,\tO\nrunner-up\tO\nto\tO\nGraf\tB-PER\nat\tO\nthe\tO\nFrench\tB-MISC\nOpen\tI-MISC\nand\tO\nWimbledon\tB-MISC\n,\tO\nbegins\tO\nplay\tO\nagainst\tO\na\tO\nqualifier\tO\nin\tO\na\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nthat\tO\nincludes\tO\nyoung\tO\ntalent\tO\nMartina\tB-PER\nHingis\tI-PER\n,\tO\nthe\tO\n16th\tO\nseed\tO\n,\tO\nbefore\tO\na\tO\nprobable\tO\nquarter-final\tO\nclash\tO\nwith\tO\nseventh-seeded\tO\nveteran\tO\nJana\tB-PER\nNovotna\tI-PER\n.\tO\n\nMartinez\tB-PER\nbegins\tO\nplay\tO\nagainst\tO\nRuxandra\tB-PER\nDragomir\tI-PER\nof\tO\nRomania\tB-LOC\n.\tO\n\nRTRS\tB-ORG\n-\tO\nTennis\tO\n-\tO\nMuster\tO\nupset\tO\n,\tO\nPhilippoussis\tB-PER\nwins\tO\n,\tO\nStoltenberg\tB-PER\nloses\tO\n.\tO\n\nTop-seeded\tO\nThomas\tB-PER\nMuster\tI-PER\nof\tO\nAustria\tB-LOC\nwas\tO\nbeaten\tO\n6-3\tO\n7-5\tO\nby\tO\n123rd-ranked\tO\nDaniel\tB-PER\nNestor\tI-PER\nof\tO\nCanada\tB-LOC\non\tO\nWednesday\tO\nin\tO\nhis\tO\nfirst\tO\nmatch\tO\nof\tO\nthe\tO\n$\tO\n2\tO\nmillion\tO\nCanadian\tB-MISC\nOpen\tI-MISC\n.\tO\n\nA\tO\nlefthander\tO\nwith\tO\na\tO\nstrong\tO\nserve\tO\n,\tO\nNestor\tB-PER\nkept\tO\nthe\tO\nrallies\tO\nshort\tO\nby\tO\nconstantly\tO\nattacking\tO\nthe\tO\nnet\tO\nand\tO\nthe\tO\ntactic\tO\nworked\tO\nin\tO\nthe\tO\nsecond-round\tO\nmatch\tO\nagainst\tO\nMuster\tB-PER\n,\tO\nplaying\tO\nhis\tO\nfirst\tO\nmatch\tO\nafter\tO\nreceiving\tO\na\tO\nfirst-round\tO\nbye\tO\nalong\tO\nwith\tO\nthe\tO\nother\tO\ntop\tO\neight\tO\nseeds\tO\n.\tO\n\nThe\tO\ntournament\tO\nalso\tO\nlost\tO\nits\tO\nsecond\tO\nseed\tO\non\tO\nthe\tO\nthird\tO\nday\tO\nof\tO\nplay\tO\nwhen\tO\nsecond-seeded\tO\nGoran\tB-PER\nIvanisevic\tI-PER\nof\tO\nCroatia\tB-LOC\nwas\tO\nbeaten\tO\n6-7(3-7\tO\n)\tO\n6-4\tO\n6-4\tO\nby\tO\nunseeded\tO\nMikael\tB-PER\nTillstrom\tI-PER\nof\tO\nSweden\tB-LOC\n.\tO\n\nOther\tO\nseeded\tO\nplayers\tO\nadvancing\tO\nwere\tO\nnumber\tO\nthree\tO\nWayne\tB-PER\nFerreira\tI-PER\nof\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n,\tO\nnumber\tO\nfour\tO\nMarcelo\tB-PER\nRios\tI-PER\nof\tO\nChile\tB-LOC\n,\tO\nnumber\tO\nsix\tO\nMaliVai\tB-PER\nWashington\tI-PER\nof\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\nand\tO\nAmerican\tB-MISC\nTodd\tB-PER\nMartin\tI-PER\n,\tO\nthe\tO\nseventh\tO\nseeed\tO\n.\tO\n\nEighth\tO\nseed\tO\nMarc\tB-PER\nRosset\tI-PER\nof\tO\nSwitzerland\tB-LOC\nwas\tO\neliminated\tO\nin\tO\na\tO\none\tO\nhour\tO\n,\tO\n55\tO\nminute\tO\nbattle\tO\nby\tO\nunseeded\tO\nMark\tB-PER\nPhilippoussis\tI-PER\nof\tO\nAustralia\tB-LOC\n.\tO\n\nPhilippoussis\tB-PER\nsaved\tO\na\tO\nmatch\tO\npoint\tO\nat\tO\n5-6\tO\nin\tO\nthe\tO\nthird-set\tO\ntie\tO\nbreak\tO\nbefore\tO\nwinning\tO\n6-3\tO\n3-6\tO\n7-6\tO\n(\tO\n8-6\tO\n)\tO\n.\tO\n\nPhilippoussis\tB-PER\n's\tO\ncompatriot\tO\n,\tO\n13th\tO\nseed\tO\nJason\tB-PER\nStoltenberg\tI-PER\n,\tO\nwas\tO\nnot\tO\nas\tO\nfortunate\tO\n.\tO\n\nHe\tO\nheld\tO\none\tO\nmatch\tO\npoint\tO\nat\tO\n9-8\tO\nin\tO\na\tO\nmarathon\tO\nthird-set\tO\ntie\tO\nbreak\tO\nbut\tO\nwas\tO\nbeaten\tO\n5-7\tO\n7-6\tO\n(\tO\n7-1\tO\n)\tO\n7-6\tO\n(\tO\n13-11\tO\n)\tO\nby\tO\nunseeded\tO\nDaniel\tB-PER\nVacek\tI-PER\nof\tO\nthe\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n.\tO\n\n\"\tO\nI\tO\nknew\tO\nI\tO\nhad\tO\nto\tO\nserve\tO\nwell\tO\nand\tO\nkeep\tO\nthe\tO\npoints\tO\nshort\tO\nand\tO\nthat\tO\n's\tO\nwhat\tO\nI\tO\nwas\tO\nable\tO\nto\tO\ndo\tO\n,\tO\n\"\tO\nsaid\tO\nNestor\tB-PER\n,\tO\nwho\tO\nranks\tO\n10th\tO\nin\tO\ndoubles\tO\n.\tO\n\nThe\tO\nlanky\tO\nCanadian\tB-MISC\nbroke\tO\nMuster\tB-PER\nat\tO\n4-3\tO\nin\tO\nthe\tO\nfirst\tO\nset\tO\nand\tO\n5-5\tO\nin\tO\nthe\tO\nsecond\tO\nbefore\tO\nending\tO\nthe\tO\nmatch\tO\non\tO\nhis\tO\nthird\tO\nmatch\tO\npoint\tO\nwhen\tO\nthe\tO\nAustrian\tB-MISC\nhit\tO\na\tO\nservice\tO\nreturn\tO\nlong\tO\n.\tO\n\n\"\tO\nI\tO\nprobably\tO\ndid\tO\nn't\tO\nhit\tO\nfive\tO\nground\tO\nstrokes\tO\nin\tO\nthe\tO\nwhole\tO\nmatch\tO\n,\tO\n\"\tO\nsaid\tO\nMuster\tB-PER\n,\tO\nonly\tO\npartly\tO\njoking\tO\n.\tO\n\"\tO\n\nPlaying\tO\nat\tO\nnight\tO\nwas\tO\nnot\tO\nMuster\tB-PER\n's\tO\npreference\tO\n.\tO\n\"\tO\n\nIvanisevic\tB-PER\nrallied\tO\nfrom\tO\na\tO\n2-5\tO\ndeficit\tO\nin\tO\nthe\tO\nfirst\tO\nset\tO\nbut\tO\nthen\tO\nplayed\tO\nerratically\tO\nagainst\tO\nthe\tO\n44th-ranked\tO\nTillstrom\tB-PER\n,\tO\nwho\tO\nwas\tO\na\tO\nsurprise\tO\nwinner\tO\nover\tO\nhis\tO\nfamous\tO\ncompatriot\tO\nStefan\tB-PER\nEdberg\tI-PER\nin\tO\nthe\tO\nsecond\tO\nround\tO\nat\tO\nWimbledon\tB-LOC\n.\tO\n\nIvanisevic\tB-PER\nhit\tO\n32\tO\naces\tO\nbut\tO\nwas\tO\noutplayed\tO\nfrom\tO\nthe\tO\nback\tO\ncourt\tO\nby\tO\nthe\tO\n24-year-old\tO\nTillstrom\tB-PER\n.\tO\n\nThe\tO\nsixth-ranked\tO\nIvanisevic\tB-PER\n,\tO\nwho\tO\nlost\tO\nin\tO\nthe\tO\nfinal\tO\nat\tO\nIndianapolis\tB-LOC\nto\tO\nworld\tO\nnumber\tO\none\tO\nPete\tB-PER\nSampras\tI-PER\nof\tO\nthe\tO\nU.S.\tB-LOC\nlast\tO\nSunday\tO\n,\tO\nmade\tO\na\tO\nquick\tO\ngetaway\tO\nafter\tO\nhis\tO\nloss\tO\nbut\tO\ndid\tO\nsay\tO\n:\tO\n\"\tO\nSomething\tO\nwas\tO\nnot\tO\nthere\tO\nwhen\tO\nI\tO\narrived\tO\n(\tO\nin\tO\nToronto\tB-LOC\n)\tO\n.\tO\n\n\"\tO\nI\tO\nthought\tO\nhe\tO\nlooked\tO\na\tO\nlittle\tO\nunfocused\tO\nat\tO\ncertain\tO\ntimes\tO\non\tO\nhis\tO\nground\tO\nstrokes\tO\n,\tO\n\"\tO\nsaid\tO\nTillstrom\tB-PER\n.\tO\n\nThe\tO\n19-year-old\tO\nPhilippoussis\tB-PER\n,\tO\nwho\tO\nbeat\tO\nSampras\tB-PER\nin\tO\nthe\tO\nthird\tO\nround\tO\nof\tO\nthis\tO\nyear\tO\n's\tO\nAustralian\tB-MISC\nOpen\tI-MISC\n,\tO\nstayed\tO\ncalm\tO\nin\tO\na\tO\nnervy\tO\nthird-set\tO\ntie\tO\nbreak\tO\nagainst\tO\nRosset\tB-PER\n.\tO\n\nSoccer\tO\n-\tO\nResults\tO\nof\tO\nSouth\tB-MISC\nKorean\tI-MISC\npro-soccer\tO\ngames\tO\n.\tO\n\nResults\tO\nof\tO\nSouth\tB-MISC\nKorean\tI-MISC\npro-soccer\tO\ngames\tO\nplayed\tO\non\tO\nWednesday\tO\n.\tO\n\nAnyang\tB-ORG\n3\tO\nChonnam\tO\n3\tO\n(\tO\nhalftime\tO\n2-0\tO\n)\tO\n\nPuchon\tO\n0\tO\nSuwon\tB-ORG\n0\tO\n(\tO\nhalftime\tO\n0-0\tO\n)\tO\n\nPuchon\tB-ORG\n1\tO\n1\tO\n0\tO\n1\tO\n0\tO\n4\tO\n\nPohang\tB-ORG\n0\tO\n1\tO\n0\tO\n3\tO\n3\tO\n1\tO\n\nChonnam\tB-ORG\n0\tO\n1\tO\n1\tO\n5\tO\n6\tO\n1\tO\n\nSenegal\tB-LOC\ncholera\tO\noutbreak\tO\nkills\tO\nfive\tO\n.\tO\n\nAn\tO\noutbreak\tO\nof\tO\ncholera\tO\nhas\tO\nkilled\tO\nfive\tO\npeople\tO\nin\tO\nthe\tO\ncentral\tO\nSenegal\tB-LOC\ntown\tO\nof\tO\nKaolack\tB-LOC\n,\tO\nwhere\tO\nhealth\tO\nauthorities\tO\nhave\tO\nrecorded\tO\n291\tO\ncases\tO\nsince\tO\nAugust\tO\n11\tO\n,\tO\na\tO\nmedical\tO\nofficial\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nPeople\tO\nare\tO\nrushing\tO\nto\tO\nthe\tO\nhospital\tO\nas\tO\nsoon\tO\nas\tO\nthe\tO\nfirst\tO\nsymptoms\tO\nappear\tO\n,\tO\nthat\tO\n's\tO\nwhy\tO\nwe\tO\nhave\tO\nfewer\tO\ndeaths\tO\n,\tO\n\"\tO\nhe\tO\ntold\tO\nReuters\tB-ORG\nby\tO\ntelephone\tO\nfrom\tO\nthe\tO\ntown\tO\n,\tO\n160\tO\nkm\tO\n(\tO\n100\tO\nmiles\tO\n)\tO\nsoutheast\tO\nof\tO\nthe\tO\nSenegalese\tB-MISC\ncapital\tO\nDakar\tB-LOC\n.\tO\n\nNigerian\tB-MISC\ngeneral\tO\ntakes\tO\nover\tO\nLiberia\tB-LOC\nECOMOG\tB-ORG\nforce\tO\n.\tO\n\nNigerian\tB-MISC\nMajor\tO\nGeneral\tO\nSam\tO\nVictor\tO\nMalu\tO\ntook\tO\nover\tO\non\tO\nThursday\tO\nas\tO\ncommander\tO\nof\tO\nthe\tO\nECOMOG\tB-ORG\npeacekeeping\tO\nforce\tO\nin\tO\nLiberia\tB-LOC\n,\tO\ntwo\tO\ndays\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nlatest\tO\nceasefire\tO\nin\tO\nthe\tO\nsix-year\tO\ncivil\tO\nwar\tO\n.\tO\n\nMalu\tB-PER\nreplaced\tO\nanother\tO\nNigerian\tB-MISC\nmajor\tO\ngeneral\tO\n,\tO\nJohn\tB-PER\nInienger\tI-PER\n,\tO\nwho\tO\ntold\tO\nofficers\tO\nat\tO\nthe\tO\nhandover\tO\nceremony\tO\nthat\tO\npeace\tO\nwas\tO\nnow\tO\nat\tO\nhand\tO\nfor\tO\nLiberia\tB-LOC\nafter\tO\nsix\tO\nyears\tO\nof\tO\nfighting\tO\nand\tO\nmore\tO\nthan\tO\na\tO\ndozen\tO\nfailed\tO\naccords\tO\n.\tO\n\n\"\tO\nThe\tO\nsearch\tO\nfor\tO\npeace\tO\nin\tO\nLiberia\tB-LOC\nhas\tO\nbeen\tO\ndifficult\tO\n,\tO\nchallenging\tO\nand\tO\nsometimes\tO\npainful\tO\n.\tO\n\nUnited\tB-ORG\nNations\tI-ORG\nmilitary\tO\nobservers\tO\ntravelling\tO\nto\tO\nthe\tO\nwestern\tO\ntown\tO\nof\tO\nTubmanburg\tB-LOC\non\tO\nWednesday\tO\nto\tO\nmonitor\tO\nthe\tO\nceasefire\tO\nwere\tO\ndelayed\tO\nby\tO\nshooting\tO\nalong\tO\nthe\tO\nhighway\tO\n,\tO\nU.N.\tB-ORG\nspecial\tO\nrepresentative\tO\nAnthony\tB-PER\nNyakyi\tI-PER\nsaid\tO\n.\tO\n\nThey\tO\nfinally\tO\nwent\tO\nahead\tO\nwith\tO\nan\tO\nescort\tO\nfrom\tO\nthe\tO\nULIMO-J\tB-ORG\nfaction\tO\n.\tO\n\nFaction\tO\nleaders\tO\nwho\tO\nagreed\tO\na\tO\nnew\tO\npeace\tO\ndeal\tO\nin\tO\nthe\tO\nNigerian\tB-MISC\ncapital\tO\nAbuja\tB-LOC\non\tO\nSaturday\tO\nhave\tO\naccused\tO\neach\tO\nother\tO\nof\tO\nbreaking\tO\nthe\tO\nceasefire\tO\n.\tO\n\nThe\tO\nECOMOG\tB-ORG\nforce\tO\n,\tO\ncurrently\tO\n10,000\tO\nstrong\tO\n,\tO\nwas\tO\nsent\tO\nto\tO\nLiberia\tB-LOC\nby\tO\nthe\tO\nEconomic\tB-ORG\nCommunity\tI-ORG\nof\tI-ORG\nWest\tI-ORG\nAfrican\tI-ORG\nStates\tI-ORG\nin\tO\n1990\tO\nat\tO\nthe\tO\nheight\tO\nof\tO\nthe\tO\nfighting\tO\n.\tO\n\nGuinea\tB-LOC\ncalls\tO\ntwo\tO\ndays\tO\nof\tO\nprayer\tO\n.\tO\n\nThe\tO\nWest\tB-MISC\nAfrican\tI-MISC\nstate\tO\nof\tO\nGuinea\tB-LOC\ndeclared\tO\nThursday\tO\nand\tO\nFriday\tO\ndays\tO\nof\tO\nnational\tO\nprayer\tO\n.\tO\n\nA\tO\ngovernment\tO\nstatement\tO\n,\tO\nbroadcast\tO\nrepeatedly\tO\nby\tO\nstate\tO\nradio\tO\n,\tO\nsaid\tO\nthe\tO\ntwo\tO\ndays\tO\nof\tO\nprayer\tO\nwere\tO\n\"\tO\nfor\tO\nthe\tO\ndead\tO\n,\tO\nfor\tO\npeace\tO\nand\tO\nprosperity\tO\nin\tO\nGuinea\tB-LOC\n,\tO\nthe\tO\nvictory\tO\nof\tO\nthe\tO\nnew\tO\ngovernment\tO\nand\tO\nthe\tO\nhealth\tO\nof\tO\nthe\tO\nhead\tO\nof\tO\nstate\tO\n\"\tO\n.\tO\n\nGuinea\tB-LOC\n's\tO\npresident\tO\n,\tO\nLansana\tO\nConte\tO\n,\tO\nvice-president\tO\nof\tO\nthe\tO\nOrganisation\tB-ORG\nof\tI-ORG\nthe\tI-ORG\nIslamic\tI-ORG\nConference\tI-ORG\n,\tO\nleft\tO\nfor\tO\nKuwait\tB-LOC\non\tO\nAugust\tO\n16\tO\nto\tO\nprepare\tO\nthe\tO\nnext\tO\nOIC\tB-ORG\nsummit\tO\nin\tO\nPakistan\tB-LOC\nin\tO\n1997\tO\n.\tO\n\nKoranic\tB-MISC\nreading\tO\nsessions\tO\nand\tO\nprayers\tO\nwere\tO\nto\tO\nbe\tO\nheld\tO\nin\tO\nthe\tO\nfarming\tO\ntown\tO\nof\tO\nBadi-Tondon\tB-LOC\n,\tO\nnear\tO\nhis\tO\nhome\tO\nabout\tO\n60\tO\nkm\tO\n(\tO\n40\tO\nmiles\tO\n)\tO\nfrom\tO\nthe\tO\ncapital\tO\nConakry\tB-LOC\n.\tO\n\nConte\tB-PER\n,\tO\nan\tO\narmy\tO\ngeneral\tO\n,\tO\nsurvived\tO\na\tO\nFebruary\tO\narmy\tO\npay\tO\nrevolt\tO\nwhich\tO\nat\tO\nthe\tO\ntime\tO\nhe\tO\ndescribed\tO\nas\tO\na\tO\nveiled\tO\nattempt\tO\nto\tO\ntopple\tO\nhim\tO\n.\tO\n\nConte\tB-PER\nseized\tO\npower\tO\nin\tO\n1984\tO\nafter\tO\nthe\tO\ndeath\tO\nof\tO\nveteran\tO\nMarxist\tB-MISC\nleader\tO\nAhmed\tB-PER\nSekou\tI-PER\nToure\tI-PER\n.\tO\n\nSouth\tB-MISC\nAfrican\tI-MISC\nanswers\tO\nU.S.\tB-LOC\nmessage\tO\nin\tO\na\tO\nbottle\tO\n.\tO\n\nA\tO\nSouth\tB-MISC\nAfrican\tI-MISC\nboy\tO\nis\tO\nwriting\tO\nback\tO\nto\tO\nan\tO\nAmerican\tB-MISC\ngirl\tO\nwhose\tO\nmessage\tO\nin\tO\na\tO\nbottle\tO\nhe\tO\nfound\tO\nwashed\tO\nup\tO\non\tO\nPresident\tO\nNelson\tB-PER\nMandela\tI-PER\n's\tO\nold\tO\nprison\tO\nisland\tO\n.\tO\n\nBut\tO\nCarlo\tB-PER\nHoffmann\tI-PER\n,\tO\nan\tO\n11-year-old\tO\njailer\tO\n's\tO\nson\tO\nwho\tO\nfound\tO\nthe\tO\nbottle\tO\non\tO\nthe\tO\nbeach\tO\nat\tO\nRobben\tB-LOC\nIsland\tI-LOC\noff\tO\nCape\tB-LOC\nTown\tI-LOC\nafter\tO\nwinter\tO\nstorms\tO\n,\tO\nwill\tO\nsend\tO\nhis\tO\nletter\tO\nback\tO\nby\tO\nordinary\tO\nmail\tO\non\tO\nThursday\tO\n,\tO\nthe\tO\npost\tO\noffice\tO\nsaid\tO\n.\tO\n\nDanielle\tB-PER\nMurray\tI-PER\nfrom\tO\nSandusky\tB-LOC\n,\tO\nOhio\tB-LOC\n,\tO\nthe\tO\nsame\tO\nage\tO\nas\tO\nher\tO\nnew\tO\npenfriend\tO\n,\tO\nasked\tO\nfor\tO\na\tO\nreply\tO\nfrom\tO\nwhoever\tO\nreceived\tO\nthe\tO\nmessage\tO\nshe\tO\nflung\tO\non\tO\nits\tO\njourney\tO\nmonths\tO\nago\tO\non\tO\nthe\tO\nother\tO\nside\tO\nof\tO\nthe\tO\nAtlantic\tB-LOC\nOcean\tI-LOC\n.\tO\n\nRottweiler\tB-MISC\nkills\tO\nSouth\tB-MISC\nAfrican\tI-MISC\ntoddler\tO\n.\tO\n\nA\tO\nrottweiler\tO\ndog\tO\nbelonging\tO\nto\tO\nan\tO\nelderly\tO\nSouth\tB-MISC\nAfrican\tI-MISC\ncouple\tO\nsavaged\tO\nto\tO\ndeath\tO\ntheir\tO\ntwo-year-old\tO\ngrandson\tO\nwho\tO\nwas\tO\nvisiting\tO\n,\tO\npolice\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\ndog\tO\nattacked\tO\nLouis\tB-PER\nBooy\tI-PER\nin\tO\nthe\tO\nfront\tO\ngarden\tO\nof\tO\nhis\tO\ngrandparents\tO\n'\tO\nhouse\tO\nin\tO\nVanderbijlpark\tB-LOC\nnear\tO\nJohannesburg\tB-LOC\non\tO\nTuesday\tO\n.\tO\n\nDogs\tO\nfierce\tO\nenough\tO\nto\tO\nscare\tO\noff\tO\nburglars\tO\nare\tO\nbecoming\tO\nincreasingly\tO\npopular\tO\nin\tO\nthe\tO\ncrime-infested\tO\nJohannesburg\tB-LOC\narea\tO\n.\tO\n\nINDICATORS\tO\n-\tO\nHungary\tB-LOC\n-\tO\nupdated\tO\nAug\tO\n22\tO\n.\tO\n\nNBH\tB-ORG\ntrade\tO\nbalance\tO\nJan-May\tO\n-\tO\n$\tO\n934\tO\nmillion\tO\n(\tO\nJan-April\tO\n-\tO\n$\tO\n774\tO\nmillion\tO\n)\tO\n\nThe\tO\nNBH\tB-ORG\nis\tO\nBBB-minus\tO\nby\tO\nDuff\tB-ORG\n&\tI-ORG\nPhelps\tI-ORG\n,\tO\nIBCA\tB-ORG\nand\tO\nThomson\tB-ORG\nBankWatch\tI-ORG\n,\tO\nBB-plus\tO\nby\tO\nS&P\tB-ORG\n,\tO\nBA1\tO\nby\tO\nMoody\tB-ORG\n's\tI-ORG\nInvestors\tI-ORG\nService\tI-ORG\n,\tO\nBBB+\tO\nby\tO\nthe\tO\nJapan\tB-ORG\nCredit\tI-ORG\nRating\tI-ORG\nAgency\tI-ORG\n.\tO\n\nThe\tO\nNBH\tB-ORG\ntrade\tO\ndata\tO\nis\tO\nbased\tO\non\tO\ncash\tO\nflow\tO\n,\tO\nMIT\tB-ORG\ndata\tO\non\tO\ncustoms\tO\nstatistics\tO\n.\tO\n\nFifty\tO\nRussians\tB-MISC\ndie\tO\nin\tO\nclash\tO\nwith\tO\nrebels-Interfax\tO\n.\tO\n\nAt\tO\nleast\tO\n50\tO\nRussian\tB-MISC\nservicemen\tO\nhave\tO\nbeen\tO\nkilled\tO\nin\tO\na\tO\nbattle\tO\nwith\tO\nseparatist\tO\nrebels\tO\nwhich\tO\nerupted\tO\nin\tO\nthe\tO\nChechen\tB-MISC\ncapital\tO\nGrozny\tB-LOC\non\tO\nThursday\tO\nand\tO\ncontinued\tO\nafter\tO\nRussia\tB-LOC\nand\tO\nthe\tO\nrebels\tO\nagreed\tO\na\tO\ntruce\tO\n,\tO\nInterfax\tB-ORG\nnews\tO\nagency\tO\nsaid\tO\n.\tO\n\nInterfax\tB-ORG\nquoted\tO\nRussian\tB-MISC\nmilitary\tO\ncommand\tO\nin\tO\nChechnya\tB-LOC\nas\tO\nsaying\tO\nthat\tO\nabout\tO\n200\tO\ninterior\tB-ORG\nministry\tI-ORG\nforces\tO\n,\tO\nsent\tO\non\tO\nreconaisance\tO\nmission\tO\n,\tO\nclashed\tO\nwith\tO\nrebels\tO\nat\tO\nMinutka\tB-LOC\nSquare\tI-LOC\n.\tO\n\nThe\tO\nInterfax\tB-ORG\nreport\tO\ncould\tO\nnot\tO\nbe\tO\nindependently\tO\nconfirmed\tO\n.\tO\n\nMoscow\tB-LOC\npeacemaker\tO\nAlexander\tB-PER\nLebed\tI-PER\nand\tO\nrebel\tO\nchief-of-staff\tO\nAslan\tB-PER\nMaskhadov\tI-PER\nsigned\tO\nan\tO\nagreement\tO\nearlier\tO\non\tO\nThursday\tO\nunder\tO\nwhich\tO\nthe\tO\ntwo\tO\nsides\tO\nwould\tO\ncease\tO\nall\tO\nhostilities\tO\nat\tO\nnoon\tO\n(\tO\n0800\tO\nGMT\tB-MISC\n)\tO\non\tO\nFriday\tO\n.\tO\n\nInterfax\tB-ORG\nmade\tO\nclear\tO\nthat\tO\nthe\tO\ninterior\tB-ORG\nministry\tI-ORG\ndetachment\tO\nhad\tO\nbeen\tO\nsent\tO\non\tO\nthe\tO\nmission\tO\nbefore\tO\nthe\tO\ntruce\tO\ndeal\tO\nhad\tO\nbeen\tO\nsigned\tO\nat\tO\nthe\tO\nlocal\tO\nequivalent\tO\nof\tO\n1500\tO\nGMT\tB-MISC\n.\tO\n\nBut\tO\nfierce\tO\nfighting\tO\nstill\tO\nraged\tO\nat\tO\n1600\tO\nGMT\tB-MISC\n,\tO\nInterfax\tB-ORG\nsaid\tO\n.\tO\n\nIt\tO\nquoted\tO\na\tO\nsource\tO\nin\tO\nthe\tO\nRussian\tB-MISC\ncommand\tO\nin\tO\nChechnya\tB-LOC\nas\tO\nsaying\tO\nthat\tO\nthe\tO\nservicemen\tO\nwere\tO\noutnumbered\tO\nby\tO\nthe\tO\nrebels\tO\n.\tO\n\nPolish\tB-MISC\nschoolgirl\tO\nblackmailer\tO\nwanted\tO\ntextbooks\tO\n.\tO\n\nGDANSK\tB-LOC\n,\tO\nPoland\tB-LOC\n1996-08-22\tO\n\nA\tO\nPolish\tB-MISC\nschoolgirl\tO\nblackmailed\tO\ntwo\tO\nwomen\tO\nwith\tO\nanonymous\tO\nletters\tO\nthreatening\tO\ndeath\tO\nand\tO\nlater\tO\nexplained\tO\nthat\tO\nshe\tO\nneeded\tO\nmoney\tO\nfor\tO\ntextbooks\tO\n,\tO\npolice\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nThe\tO\n13-year-old\tO\ngirl\tO\ntried\tO\nto\tO\nextract\tO\n60\tO\nand\tO\n70\tO\nzlotys\tO\n(\tO\n$\tO\n22\tO\nand\tO\n$\tO\n26\tO\n)\tO\nfrom\tO\ntwo\tO\nresidents\tO\nof\tO\nSierakowice\tB-LOC\nby\tO\nthreatening\tO\nto\tO\ntake\tO\ntheir\tO\nlives\tO\n,\tO\n\"\tO\na\tO\npolice\tO\nspokesman\tO\nsaid\tO\nin\tO\nthe\tO\nnearby\tO\nnorthern\tO\ncity\tO\nof\tO\nGdansk\tB-LOC\non\tO\nThursday\tO\n.\tO\n\nHe\tO\nsaid\tO\nthe\tO\nwomen\tO\nreported\tO\nthe\tO\nblackmail\tO\nletters\tO\nand\tO\npolice\tO\ncaught\tO\nthe\tO\ngirl\tO\non\tO\nWednesday\tO\nas\tO\nshe\tO\ntried\tO\nto\tO\npick\tO\nup\tO\nthe\tO\ncash\tO\nat\tO\nthe\tO\nSierakowice\tB-LOC\nrailway\tO\nstation\tO\n.\tO\n\n\"\tO\nInterviewed\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\na\tO\npsychologist\tO\n,\tO\nshe\tO\nsaid\tO\nshe\tO\nwanted\tO\nto\tO\nuse\tO\nthe\tO\nmoney\tO\nfor\tO\nschool\tO\nbooks\tO\nand\tO\nclothes\tO\n,\tO\n\"\tO\nspokesman\tO\nKazimierz\tB-PER\nSocha\tI-PER\ntold\tO\nReuters\tB-ORG\n.\tO\n\nCzech\tB-MISC\nCNB-120\tB-MISC\nindex\tO\nrises\tO\n1.2\tO\npts\tO\nto\tO\n869.3\tO\n.\tO\n\nThe\tO\nCNB-120\tB-MISC\nindex\tO\n,\tO\na\tO\nbroad\tO\ndaily\tO\nmeasure\tO\nof\tO\nCzech\tB-MISC\nequities\tO\n,\tO\nrose\tO\n1.2\tO\npoints\tO\non\tO\nThursday\tO\nto\tO\n869.3\tO\n,\tO\nthe\tO\nCzech\tB-ORG\nNational\tI-ORG\nBank\tI-ORG\n(\tO\nCNB\tB-ORG\n)\tO\nsaid\tO\n.\tO\n\n--\tO\nPrague\tB-ORG\nNewsroom\tI-ORG\n,\tO\n42-2-2423-0003\tO\n\nRussians\tB-MISC\n,\tO\nrebels\tO\nsign\tO\ndeal\tO\nin\tO\nChechnya\tB-LOC\n.\tO\n\nNOVYE\tB-LOC\nATAGI\tI-LOC\n,\tO\nRussia\tB-LOC\n1996-08-22\tO\n\nRussian\tB-MISC\nPresident\tO\nBoris\tB-PER\nYeltsin\tI-PER\n's\tO\nsecurity\tO\nsupremo\tO\nAlexander\tB-PER\nLebed\tI-PER\nand\tO\nChechen\tB-MISC\nrebel\tO\nchief-of-staff\tO\nAslan\tB-PER\nMaskhadov\tI-PER\nsigned\tO\na\tO\ndeal\tO\non\tO\nThursday\tO\naimed\tO\nat\tO\nending\tO\nthree\tO\nweeks\tO\nof\tO\nrenewed\tO\nfighting\tO\nin\tO\nthe\tO\nregion\tO\n.\tO\n\nThe\tO\nfinal\tO\ncontents\tO\nof\tO\nthe\tO\ndocument\tO\nnegotiated\tO\nin\tO\nthis\tO\nvillage\tO\nsouth\tO\nof\tO\nthe\tO\nChechen\tB-MISC\ncapital\tO\nGrozny\tB-LOC\nhave\tO\nnot\tO\nbeen\tO\nofficially\tO\ndisclosed\tO\n.\tO\n\nItar-Tass\tB-ORG\nnews\tO\nagency\tO\nsaid\tO\nit\tO\nprovided\tO\nfor\tO\nthe\tO\ndisengagement\tO\nof\tO\nRussian\tB-MISC\nand\tO\nrebel\tO\nforces\tO\nin\tO\nChechnya\tB-LOC\n.\tO\n\nLebed\tB-PER\naide\tO\nsays\tO\nRussian-Chechen\tB-MISC\ntalks\tO\ngoing\tO\nwell\tO\n.\tO\n\nTalks\tO\nbetween\tO\nRussia\tB-LOC\n's\tO\nAlexander\tB-PER\nLebed\tI-PER\nand\tO\nChechen\tB-MISC\nseparatist\tO\nleaders\tO\nwere\tO\ngoing\tO\nwell\tO\non\tO\nThursday\tO\nand\tO\nthe\tO\ntwo\tO\nsides\tO\nwere\tO\nworking\tO\nout\tO\na\tO\ndetailed\tO\nschedule\tO\non\tO\nhow\tO\nto\tO\nstop\tO\nthe\tO\nwar\tO\n,\tO\na\tO\nLebed\tB-PER\naide\tO\nsaid\tO\n.\tO\n\nPress\tO\nspokesman\tO\nAlexander\tB-PER\nBarkhatov\tI-PER\ntold\tO\nreporters\tO\nthe\tO\nnegotiations\tO\n,\tO\nbeing\tO\nheld\tO\nat\tO\nthis\tO\nrebel-held\tO\nvillage\tO\nsome\tO\n20\tO\nkm\tO\n(\tO\n12\tO\nmiles\tO\n)\tO\nsouth\tO\nof\tO\nthe\tO\nChechen\tB-MISC\ncapital\tO\nGrozny\tB-LOC\n,\tO\nwere\tO\nprogressing\tO\nbriskly\tO\nand\tO\nbeing\tO\nconducted\tO\nin\tO\na\tO\ngood\tO\nmood\tO\n.\tO\n\nHe\tO\nsaid\tO\na\tO\ndocument\tO\nwould\tO\nbe\tO\ncompleted\tO\nin\tO\nan\tO\nhour\tO\n's\tO\ntime\tO\nfor\tO\nsignature\tO\nby\tO\nthe\tO\ntwo\tO\nsides\tO\n,\tO\nwho\tO\nwere\tO\nworking\tO\non\tO\na\tO\n\"\tO\nday-by-day\tO\nschedule\tO\nto\tO\nstop\tO\nthe\tO\nwar\tO\nin\tO\nChechnya\tB-LOC\n.\tO\n\"\tO\n\nYeltsin\tB-PER\nshown\tO\non\tO\nRussian\tB-MISC\ntelevision\tO\n.\tO\n\nRussian\tB-MISC\ntelevision\tO\nshowed\tO\na\tO\nbrief\tO\nclip\tO\nof\tO\nBoris\tB-PER\nYeltsin\tI-PER\non\tO\nThursday\tO\n,\tO\nwith\tO\nthe\tO\npresident\tO\nlaughing\tO\nand\tO\nsmiling\tO\nas\tO\nhe\tO\nspoke\tO\nto\tO\nnominee\tO\nhealth\tO\nminister\tO\nTatyana\tB-PER\nDmitrieva\tI-PER\n.\tO\n\nHe\tO\nreturned\tO\nto\tO\nthe\tO\nKremlin\tB-LOC\non\tO\nThursday\tO\nafter\tO\na\tO\ntwo-day\tO\nbreak\tO\nin\tO\nthe\tO\nlakelands\tO\nof\tO\nnorthwestern\tO\nRussia\tB-LOC\n.\tO\n\nPRESS\tO\nDIGEST\tO\n-\tO\nBosnia\tB-LOC\n-\tO\nAug\tO\n22\tO\n.\tO\n\nThese\tO\nare\tO\nthe\tO\nleading\tO\nstories\tO\nin\tO\nthe\tO\nSarajevo\tB-LOC\npress\tO\non\tO\nThursday\tO\n.\tO\n\n-\tO\nThe\tO\nBosnian\tB-MISC\nfederation\tO\nlaunches\tO\na\tO\ncommon\tO\npayment\tO\nsystem\tO\non\tO\nFriday\tO\n.\tO\n\nUnder\tO\nthe\tO\nnew\tO\nsystem\tO\ntaxes\tO\nand\tO\ncustoms\tO\nmay\tO\nbe\tO\npaid\tO\nin\tO\nthe\tO\nBosnian\tB-MISC\ndinar\tO\n,\tO\nthe\tO\nCroatian\tB-MISC\nkuna\tO\nor\tO\nthe\tO\nDeutsche\tO\nmark\tO\nuntil\tO\na\tO\nnew\tO\nBosnian\tB-MISC\ncurrency\tO\nis\tO\nintroduced\tO\n.\tO\n\n-\tO\nThe\tO\npresident\tO\nof\tO\nthe\tO\nBosnian\tB-ORG\nAssociation\tI-ORG\nfor\tI-ORG\nRefugees\tI-ORG\nand\tI-ORG\nDisplaced\tI-ORG\nPersons\tI-ORG\n,\tO\nMirhunisa\tB-PER\nKomarica\tI-PER\nsays\tO\nmany\tO\nsurvivors\tO\nof\tO\nthe\tO\n1995\tO\nmassacre\tO\nin\tO\nthe\tO\nBosnian\tB-MISC\ntown\tO\nof\tO\nSrebrenica\tB-LOC\nare\tO\nlanguishing\tO\nas\tO\nforced\tO\nlaborers\tO\nin\tO\nSerbian\tB-MISC\nmines\tO\n.\tO\n\nAccording\tO\nto\tO\nKomarica\tB-PER\n,\tO\n2,400\tO\nmale\tO\nresidents\tO\nof\tO\nSrebrenica\tB-LOC\nwork\tO\nin\tO\nthe\tO\nTrepca\tB-LOC\nmine\tO\nand\tO\n1,900\tO\nwork\tO\nin\tO\na\tO\nmine\tO\nin\tO\nAleksandrovac\tB-LOC\n.\tO\n\n-\tO\nSlovenian\tB-MISC\npolice\tO\nbriefly\tO\ndetain\tO\ntwo\tO\nBosnian\tB-MISC\nopposition\tO\nleaders\tO\nin\tO\nLjubljana\tB-LOC\nand\tO\ncancel\tO\nopposition\tO\npolitical\tO\nrallies\tO\nin\tO\nLjubljana\tB-LOC\nand\tO\nMaribor\tB-LOC\n.\tO\n\n--\tO\nSarajevo\tB-LOC\nnewsroom\tO\n,\tO\n+387-71-663-864\tO\n.\tO\n\nGrozny\tB-LOC\nquiet\tO\novernight\tO\nafter\tO\nraids\tO\n.\tO\n\nALKHAN-YURT\tB-LOC\n,\tO\nRussia\tB-LOC\n1996-08-22\tO\n\nThe\tO\ncity\tO\nof\tO\nGrozny\tB-LOC\n,\tO\npounded\tO\nby\tO\nRussian\tB-MISC\nplanes\tO\nand\tO\nartillery\tO\nfor\tO\nhours\tO\non\tO\nWednesday\tO\n,\tO\ncalmed\tO\ndown\tO\novernight\tO\n,\tO\nalthough\tO\nsporadic\tO\nexplosions\tO\nand\tO\nshooting\tO\ncould\tO\nstill\tO\nbe\tO\nheard\tO\n.\tO\n\nReuters\tO\ncorrespondent\tO\nLawrence\tB-PER\nSheets\tI-PER\n,\tO\nspeaking\tO\nfrom\tO\nthe\tO\nnearby\tO\nvillage\tO\nof\tO\nAlkhan-Yurt\tB-LOC\n,\tO\nsaid\tO\nhe\tO\nhad\tO\nheard\tO\nlittle\tO\nfrom\tO\nGrozny\tB-LOC\nsince\tO\nWednesday\tO\nevening\tO\n's\tO\narrival\tO\nof\tO\nRussian\tB-MISC\nsecurity\tO\nchief\tO\nAlexander\tB-PER\nLebed\tI-PER\n,\tO\nwho\tO\nsaid\tO\nhe\tO\n\"\tO\ncame\tO\nwith\tO\npeace\tO\n\"\tO\n.\tO\n\nLebed\tB-PER\nsaid\tO\non\tO\nWednesday\tO\nhe\tO\nhad\tO\nclinched\tO\na\tO\ntruce\tO\nwith\tO\nChechen\tB-MISC\nseparatists\tO\nand\tO\nhe\tO\npromised\tO\nto\tO\nhalt\tO\na\tO\nthreatened\tO\nbombing\tO\nassault\tO\non\tO\nGrozny\tB-LOC\n,\tO\nwhich\tO\nthe\tO\nrebels\tO\nhave\tO\nheld\tO\nsince\tO\nAugust\tO\n6\tO\n.\tO\n\nBoat\tO\npassengers\tO\nrescued\tO\noff\tO\nColombian\tB-MISC\ncoast\tO\n.\tO\n\nBOGOTA\tB-LOC\n,\tO\nColombia\tB-LOC\n1996-08-22\tO\n\nColombia\tB-LOC\n's\tO\nCoast\tB-ORG\nGuard\tI-ORG\non\tO\nThursday\tO\nrescued\tO\n12\tO\npeople\tO\nlost\tO\nfor\tO\nthree\tO\ndays\tO\nin\tO\nan\tO\nopen\tO\nboat\tO\noff\tO\nthe\tO\nPacific\tB-LOC\ncoast\tO\n,\tO\nofficials\tO\nsaid\tO\n.\tO\n\nThe\tO\nboat\tO\nhad\tO\nbeen\tO\nmissing\tO\nsince\tO\nMonday\tO\nafternoon\tO\nwhen\tO\nit\tO\nleft\tO\nthe\tO\ntiny\tO\nisland\tO\nof\tO\nGorgona\tB-LOC\noff\tO\nColombia\tB-LOC\n's\tO\nsouthwest\tO\ncoast\tO\nwith\tO\nsightseers\tO\nfor\tO\na\tO\nreturn\tO\ntrip\tO\nto\tO\nNarino\tB-LOC\nprovince\tO\n,\tO\nnear\tO\nthe\tO\nborder\tO\nwith\tO\nEcuador\tB-LOC\n.\tO\n\nThe\tO\nboat\tO\nran\tO\nout\tO\nof\tO\nfuel\tO\nand\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nradio\tO\nto\tO\ncall\tO\nfor\tO\nhelp\tO\n,\tO\nNavy\tB-ORG\nspokesman\tO\nLt.\tO\nItalo\tB-PER\nPineda\tI-PER\nsaid\tO\n.\tO\n\nThe\tO\nboat\tO\nwas\tO\ntowed\tO\nto\tO\nthe\tO\nport\tO\ncity\tO\nof\tO\nBuenaventura\tB-LOC\n.\tO\n\nArgentine\tB-MISC\nJuly\tO\nraw\tO\nsteel\tO\noutput\tO\nup\tO\n14.8\tO\npct\tO\nvs\tO\n'\tO\n95\tO\n.\tO\n\nArgentine\tB-MISC\nraw\tO\nsteel\tO\noutput\tO\nwas\tO\n355,900\tO\ntonnes\tO\nin\tO\nJuly\tO\n,\tO\n14.8\tO\npercent\tO\nhigher\tO\nthan\tO\nin\tO\nJuly\tO\n1995\tO\nand\tO\nup\tO\n1.9\tO\npercent\tO\nfrom\tO\nJune\tO\n,\tO\nSteel\tO\nIndustry\tO\nCenter\tO\nsaid\tO\nThursday\tO\n.\tO\n\n--\tO\nJason\tB-PER\nWebb\tI-PER\n,\tO\nBuenos\tB-ORG\nAires\tI-ORG\nNewsroom\tI-ORG\n+541\tO\n318-0655\tO\n\nPeru\tB-LOC\n's\tO\nguerrillas\tO\nkill\tO\none\tO\n,\tO\ntake\tO\n8\tO\nhostage\tO\nin\tO\njungle\tO\n.\tO\n\nLIMA\tB-LOC\n,\tO\nPeru\tB-LOC\n1996-08-21\tO\n\nPeruvian\tB-MISC\nguerrillas\tO\nkilled\tO\none\tO\nman\tO\nand\tO\ntook\tO\neight\tO\npeople\tO\nhostage\tO\nafter\tO\ntaking\tO\nover\tO\na\tO\nvillage\tO\nin\tO\nthe\tO\ncountry\tO\n's\tO\nnortheastern\tO\njungle\tO\nregion\tO\n,\tO\nanti-\tO\nterrorist\tO\npolice\tO\nsources\tO\nsaid\tO\non\tO\nWednesday\tO\n.\tO\n\nFor\tO\nthree\tO\nhours\tO\non\tO\nTuesday\tO\n,\tO\naround\tO\n100\tO\nmembers\tO\nof\tO\nthe\tO\nMaoist\tB-MISC\nrebel\tO\ngroup\tO\nShining\tB-ORG\nPath\tI-ORG\ntook\tO\ncontrol\tO\nof\tO\nAlomella\tB-LOC\nRobles\tI-LOC\n,\tO\na\tO\nsmall\tO\nvillage\tO\nabout\tO\n345\tO\nmiles\tO\n(\tO\n550\tO\nkm\tO\n)\tO\nnortheast\tO\nof\tO\nLima\tB-LOC\n,\tO\nthe\tO\nsources\tO\nsaid\tO\n.\tO\n\nIn\tO\nrecent\tO\nmonths\tO\nthe\tO\nShining\tB-ORG\nPath\tI-ORG\n,\tO\nseverely\tO\nweakened\tO\nsince\tO\nthe\tO\n1992\tO\ncapture\tO\nof\tO\nits\tO\nleader\tO\nAbimael\tB-PER\nGuzman\tI-PER\n,\tO\nhas\tO\nbeen\tO\nstepping\tO\nup\tO\nboth\tO\nits\tO\nmilitary\tO\nand\tO\npropaganda\tO\nactivities\tO\n.\tO\n\nPeru\tB-LOC\n's\tO\nguerrilla\tO\nconflicts\tO\nhave\tO\ncost\tO\nat\tO\nleast\tO\n30,000\tO\nlives\tO\nand\tO\n$\tO\n25\tO\nbillion\tO\nin\tO\ndamage\tO\nto\tO\ninfrastructure\tO\nsince\tO\n1980\tO\n.\tO\n\nFormer\tO\nSurinam\tB-LOC\nrebel\tO\nleader\tO\nheld\tO\nafter\tO\nshooting\tO\n.\tO\n\nPARAMARIBO\tO\n,\tO\nSurinam\tB-LOC\n1996-08-21\tO\n\nFlamboyant\tO\nformer\tO\nSurinamese\tB-MISC\nrebel\tO\nleader\tO\nRonny\tB-PER\nBrunswijk\tI-PER\nwas\tO\nin\tO\ncustody\tO\non\tO\nWednesday\tO\ncharged\tO\nwith\tO\nattempted\tO\nmurder\tO\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nBrunswijk\tB-PER\nturned\tO\nhimself\tO\ninto\tO\npolice\tO\nafter\tO\nFreddy\tB-PER\nPinas\tI-PER\n,\tO\na\tO\nSurinamese-born\tB-MISC\nvisitor\tO\nfrom\tO\nthe\tO\nNetherlands\tB-LOC\n,\tO\naccused\tO\nBrunswijk\tB-PER\nof\tO\ntrying\tO\nto\tO\nkill\tO\nhim\tO\non\tO\nSunday\tO\nafter\tO\na\tO\nbar-room\tO\nbrawl\tO\nin\tO\nthe\tO\nsmall\tO\nmining\tO\ntown\tO\nof\tO\nMoengo\tB-LOC\n,\tO\nabout\tO\n56\tO\nmiles\tO\n(\tO\n90\tO\nkm\tO\n)\tO\neast\tO\nof\tO\nParamaribo\tB-LOC\n,\tO\nsaid\tO\npolice\tO\nspokesman\tO\nRo\tB-PER\nGajadhar\tI-PER\n.\tO\n\nPinas\tB-PER\n,\tO\nshowing\tO\ncuts\tO\nand\tO\nbruises\tO\non\tO\nhis\tO\nface\tO\n,\tO\ntold\tO\nreporters\tO\nthe\tO\nformer\tO\nhead\tO\nof\tO\nthe\tO\nfeared\tO\nJungle\tB-ORG\nCommand\tI-ORG\nhad\tO\ntried\tO\nand\tO\nfailed\tO\nto\tO\nshoot\tO\nhim\tO\nafter\tO\nPinas\tB-PER\nobjected\tO\nto\tO\nBrunswijk\tB-PER\n's\tO\nadvances\tO\ntoward\tO\nhis\tO\nwife\tO\n.\tO\n\nPinas\tB-PER\nsaid\tO\nBrunswijk\tB-PER\nthen\tO\nordered\tO\nhis\tO\nbodyguards\tO\nto\tO\nbeat\tO\nhim\tO\nup\tO\n.\tO\n\nBrunswijk\tB-PER\n,\tO\n35\tO\n,\tO\ndenied\tO\nthe\tO\ncharges\tO\nand\tO\nsaid\tO\nhe\tO\nhad\tO\nmerely\tO\ndefended\tO\nhimself\tO\nwhen\tO\nPinas\tB-PER\nattacked\tO\nhim\tO\nwith\tO\na\tO\nbottle\tO\n.\tO\n\nIt\tO\nwas\tO\nthe\tO\nsecond\tO\ntime\tO\nBrunswijk\tB-PER\nhad\tO\nbeen\tO\ncharged\tO\nwith\tO\nattempted\tO\nmurder\tO\nin\tO\nless\tO\nthan\tO\ntwo\tO\nyears\tO\n.\tO\n\nBrunswijk\tB-PER\nled\tO\na\tO\nrebel\tO\ngroup\tO\nof\tO\nabout\tO\n1,000\tO\nin\tO\na\tO\n1986\tO\nuprising\tO\nagainst\tO\nthe\tO\nregime\tO\nof\tO\nmilitary\tO\nstrongman\tO\nDesi\tB-PER\nBouterse\tI-PER\n.\tO\n\nThe\tO\nconflict\tO\n,\tO\nwhich\tO\nkilled\tO\nmore\tO\nthan\tO\n500\tO\nand\tO\ncaused\tO\nthousands\tO\nto\tO\nflee\tO\nto\tO\nneighbouring\tO\nFrench\tB-LOC\nGuiana\tI-LOC\nin\tO\nthe\tO\nlate\tO\n1980s\tO\n,\tO\neventually\tO\npaved\tO\nthe\tO\nway\tO\nto\tO\ndemocratic\tO\nelections\tO\nin\tO\n1991\tO\n.\tO\n\nDespite\tO\nnumerous\tO\nproblems\tO\nwith\tO\nauthorities\tO\n,\tO\nBrunswijk\tB-PER\nwent\tO\non\tO\nto\tO\nbecome\tO\na\tO\nsuccessful\tO\nbusinessman\tO\nwith\tO\nmining\tO\nand\tO\nlogging\tO\ninterests\tO\n.\tO\n\nNoisy\tO\nsaw\tO\nleads\tO\nThai\tB-MISC\npolice\tO\nto\tO\nheroin\tO\nhideaway\tO\n.\tO\n\nA\tO\nHong\tB-LOC\nKong\tI-LOC\ncarpenter\tO\nwas\tO\narrested\tO\nin\tO\nthe\tO\nThai\tB-MISC\nseaside\tO\ntown\tO\nof\tO\nPattaya\tB-LOC\nafter\tO\npolice\tO\nseized\tO\n18\tO\nkg\tO\n(\tO\n39.7\tO\npounds\tO\n)\tO\nof\tO\nheroin\tO\nfollowing\tO\ncomplaints\tO\nby\tO\nresidents\tO\nof\tO\na\tO\nnoisy\tO\nsaw\tO\n,\tO\npolice\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nCheung\tB-PER\nSiu\tI-PER\nMan\tI-PER\n,\tO\n40\tO\n,\tO\nwas\tO\narrested\tO\nlate\tO\non\tO\nWednesday\tO\nafter\tO\npolice\tO\nsearched\tO\na\tO\nhouse\tO\nand\tO\nfound\tO\nheroin\tO\nin\tO\nbags\tO\nand\tO\nhidden\tO\nin\tO\nhollow\tO\nspaces\tO\nin\tO\nwooden\tO\nplanks\tO\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nCheung\tB-PER\nwas\tO\nbeing\tO\ndetained\tO\npending\tO\nformal\tO\ncharges\tO\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nAustralia\tB-LOC\nforeign\tO\nminister\tO\narrives\tO\nin\tO\nChina\tB-LOC\n.\tO\n\nAustralian\tB-MISC\nForeign\tO\nMinister\tO\nAlexander\tB-PER\nDowner\tI-PER\narrived\tO\nin\tO\nBeijing\tB-LOC\non\tO\nThursday\tO\nfor\tO\na\tO\nfour-day\tO\nvisit\tO\nthat\tO\nfollows\tO\nrising\tO\nfriction\tO\nbetween\tO\nthe\tO\ntwo\tO\nnations\tO\nin\tO\nrecent\tO\nweeks\tO\n.\tO\n\nDowner\tB-PER\nwas\tO\nto\tO\nmeet\tO\nChinese\tB-MISC\nForeign\tO\nMinister\tO\nQian\tB-PER\nQichen\tI-PER\nand\tO\nsign\tO\nan\tO\nagreement\tO\non\tO\nan\tO\nAustralian\tB-MISC\nconsulate\tO\nin\tO\nHong\tB-LOC\nKong\tI-LOC\n,\tO\nan\tO\nofficial\tO\nof\tO\nthe\tO\nAustralian\tB-MISC\nembassy\tO\nin\tO\nBeijing\tB-LOC\nsaid\tO\n.\tO\n\nChina\tB-LOC\nwill\tO\nresume\tO\nsovereignty\tO\nover\tO\nHong\tB-LOC\nKong\tI-LOC\n,\tO\na\tO\nBritish\tB-MISC\ncolony\tO\n,\tO\nin\tO\nmid-1997\tO\n.\tO\n\nRelations\tO\nbetween\tO\nChina\tB-LOC\nand\tO\nAustralia\tB-LOC\nhave\tO\nbeen\tO\nstrained\tO\nin\tO\nrecent\tO\nweeks\tO\nbecause\tO\nof\tO\nAustralia\tB-LOC\n's\tO\nplan\tO\nto\tO\nsell\tO\nuranium\tO\nto\tO\nChina\tB-LOC\n's\tO\nrival\tO\nTaiwan\tB-LOC\n.\tO\n\nOther\tO\nissues\tO\naffecting\tO\nties\tO\ninclude\tO\nplans\tO\nby\tO\nan\tO\nAustralian\tB-MISC\ncabinet\tO\nminister\tO\nto\tO\nvisit\tO\nTaiwan\tB-LOC\n,\tO\na\tO\nsecurity\tO\npact\tO\nbetween\tO\nCanberra\tB-LOC\nand\tO\nWashington\tB-LOC\nand\tO\na\tO\npossible\tO\nvisit\tO\nto\tO\nAustralia\tB-LOC\nnext\tO\nmonth\tO\nby\tO\nTibet\tB-LOC\n's\tO\nexiled\tO\nspiritual\tO\nleader\tO\nthe\tO\nDalai\tB-PER\nLama\tI-PER\n.\tO\n\nDowner\tB-PER\nis\tO\nthe\tO\nfirst\tO\nAustralian\tB-MISC\nminister\tO\nto\tO\nvisit\tO\nChina\tB-LOC\nsince\tO\nthe\tO\nnew\tO\nconservative\tO\ngovernment\tO\ntook\tO\noffice\tO\nin\tO\nCanberra\tB-LOC\nin\tO\nMarch\tO\n.\tO\n\nPalestinians\tB-MISC\naccuse\tO\nPA\tB-ORG\nof\tO\nbanning\tO\nbooks\tO\n.\tO\n\nNABLUS\tO\n,\tO\nWest\tB-LOC\nBank\tI-LOC\n1996-08-22\tO\n\nA\tO\nWest\tB-LOC\nBank\tI-LOC\nbookseller\tO\ncharged\tO\non\tO\nThursday\tO\nthat\tO\nthe\tO\nPalestinian\tB-ORG\nInformation\tI-ORG\nMinistry\tI-ORG\nhas\tO\nforced\tO\nhim\tO\nto\tO\nsign\tO\nan\tO\nundertaking\tO\nnot\tO\nto\tO\ndistribute\tO\nbooks\tO\nwritten\tO\nby\tO\ncritics\tO\nof\tO\nIsraeli-PLO\tB-MISC\nself-rule\tO\ndeals\tO\n.\tO\n\nOne\tO\nofficial\tO\ntold\tO\nme\tO\n'\tO\nyou\tO\nhave\tO\nto\tO\neither\tO\ndestroy\tO\nthe\tO\nbooks\tO\nor\tO\nreturn\tO\nthem\tO\nto\tO\nAmman\tB-LOC\n'\tO\n,\tO\n\"\tO\nDaoud\tB-PER\nMakkawi\tI-PER\n,\tO\nowner\tO\nof\tO\nthe\tO\nNablus-based\tB-MISC\nal-Risala\tB-LOC\nbookshop\tO\n,\tO\ntold\tO\nReuters\tB-ORG\n.\tO\n\nHe\tO\nsaid\tO\nministry\tO\nofficials\tO\nmade\tO\nhim\tO\nsign\tO\nthis\tO\na\tO\nfew\tO\nweeks\tO\nago\tO\nafter\tO\nhe\tO\nbrought\tO\nabout\tO\na\tO\ndozen\tO\ncopies\tO\nfrom\tO\nJordan\tB-LOC\nof\tO\na\tO\nbook\tO\nby\tO\nEdward\tB-PER\nSaid\tI-PER\n,\tO\na\tO\nprominent\tO\nscholar\tO\nat\tO\nNew\tB-LOC\nYork\tI-LOC\nCity\tI-LOC\n's\tO\nColumbia\tB-ORG\nUniversity\tI-ORG\n.\tO\n\nSaid\tB-PER\n,\tO\na\tO\nU.S.\tB-LOC\ncitizen\tO\nof\tO\nPalestinian\tB-MISC\norigin\tO\n,\tO\nhas\tO\nbeen\tO\nan\tO\noutspoken\tO\ncritic\tO\nof\tO\nthe\tO\n1993\tO\nIsraeli-PLO\tB-MISC\nself-rule\tO\ndeal\tO\nand\tO\nhas\tO\nwritten\tO\nat\tO\nleast\tO\ntwo\tO\nbooks\tO\non\tO\nthe\tO\naccord\tO\n.\tO\n\nOn\tO\nWednesday\tO\na\tO\nbookseller\tO\nin\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\ntown\tO\nof\tO\nRamallah\tB-LOC\nsaid\tO\npolice\tO\nabout\tO\na\tO\nmonth\tO\nago\tO\nconfiscated\tO\nseveral\tO\ncopies\tO\nof\tO\ntwo\tO\nof\tO\nSaid\tB-PER\n's\tO\nbooks\tO\non\tO\nthe\tO\nIsrael-PLO\tB-MISC\nself-rule\tO\ndeals\tO\n.\tO\n\nPalestinian\tB-ORG\nInformation\tI-ORG\nMinistry\tI-ORG\nDirector-General\tO\nMutawakel\tB-PER\nTaha\tI-PER\ndenied\tO\nthat\tO\nministry\tO\nofficials\tO\nforced\tO\nanyone\tO\nto\tO\nsign\tO\nany\tO\nundertaking\tO\nand\tO\ninsisted\tO\nthat\tO\nthe\tO\nPalestinian\tB-ORG\nAuthority\tI-ORG\nhas\tO\nno\tO\nplans\tO\nto\tO\ncensor\tO\nbooks\tO\n.\tO\n\n\"\tO\nThere\tO\nis\tO\nno\tO\nstrategy\tO\nto\tO\nban\tO\nbooks\tO\nor\tO\nto\tO\nsuppress\tO\nfreedom\tO\nof\tO\nexpression\tO\nin\tO\nany\tO\nform\tO\nwhatsoever\tO\n,\tO\n\"\tO\nTaha\tB-PER\ntold\tO\nReuters\tB-ORG\n.\tO\n\nBut\tO\nTaha\tB-PER\nsaid\tO\nthat\tO\nthe\tO\nabsence\tO\nof\tO\nrelevent\tO\nlegislations\tO\nmay\tO\nhave\tO\nresulted\tO\nin\tO\nsome\tO\nmistakes\tO\nby\tO\nsome\tO\nsecurity\tO\nofficials\tO\n.\tO\n\nDaoud\tO\nsaid\tO\nbooks\tO\nby\tO\nother\tO\nauthors\tO\n,\tO\nincluding\tO\nBritish\tB-MISC\nJournalist\tO\nPatrick\tB-PER\nSeale\tI-PER\n,\tO\nwere\tO\nalso\tO\nbanned\tO\n.\tO\n\nDaoud\tB-PER\nsaid\tO\n.\tO\n\nThousands\tO\nof\tO\nbooks\tO\nwere\tO\nbanned\tO\nfrom\tO\nsale\tO\nin\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\nand\tO\nGaza\tB-LOC\nStrip\tI-LOC\nby\tO\nthe\tO\nIsraeli\tB-MISC\nmilitary\tO\nauthorities\tO\nbefore\tO\nthe\tO\nJewish\tB-MISC\nstate\tO\nhanded\tO\nover\tO\nparts\tO\nof\tO\nthe\tO\ntwo\tO\nareas\tO\nto\tO\nthe\tO\nPLO\tB-ORG\nunder\tO\na\tO\nself-rule\tO\ndeal\tO\nin\tO\n1994\tO\n.\tO\n\nEgypt\tB-LOC\nblames\tO\nIstanbul\tB-LOC\ncontrol\tO\ntower\tO\nfor\tO\naccident\tO\n.\tO\n\nThe\tO\nchairman\tO\nof\tO\nnational\tO\ncarrier\tO\nEgyptAir\tB-ORG\non\tO\nThursday\tO\nblamed\tO\nthe\tO\ncontrol\tO\ntower\tO\nat\tO\nIstanbul\tB-LOC\nairport\tO\nfor\tO\nthe\tO\nEgyptAir\tB-ORG\nplane\tO\naccident\tO\n.\tO\n\nTwenty\tO\npeople\tO\nwere\tO\ninjured\tO\non\tO\nWednesday\tO\nwhen\tO\nthe\tO\nEgyptAir\tB-ORG\nBoeing\tB-MISC\n707\tO\novershot\tO\nthe\tO\nrunway\tO\n,\tO\ncaught\tO\nfire\tO\n,\tO\nhit\tO\na\tO\ntaxi\tO\nand\tO\nskipped\tO\nacross\tO\na\tO\nroad\tO\nonto\tO\na\tO\nrailway\tO\nline\tO\n.\tO\n\nChairman\tO\nMohamed\tB-PER\nFahim\tI-PER\nRayyan\tI-PER\ntold\tO\na\tO\nnews\tO\nconference\tO\nat\tO\nCairo\tO\nairport\tO\n:\tO\n\"\tO\nThe\tO\ncontrol\tO\ntower\tO\nshould\tO\nhave\tO\nallocated\tO\nthe\tO\nplane\tO\nanother\tO\nrunway\tO\n,\tO\ninstead\tO\nof\tO\nthe\tO\none\tO\nthe\tO\nplane\tO\nlanded\tO\non\tO\n.\tO\n\"\tO\n\nHe\tO\nsaid\tO\na\tO\nTurkish\tB-MISC\ncivil\tO\naviation\tO\nauthority\tO\nofficial\tO\nhad\tO\nmade\tO\nthe\tO\nsame\tO\npoint\tO\nand\tO\nhe\tO\nnoted\tO\nthat\tO\na\tO\nTurkish\tB-MISC\nplane\tO\nhad\tO\na\tO\nsimilar\tO\naccident\tO\nthere\tO\nin\tO\n1994\tO\n.\tO\n\nThe\tO\nEgyptAir\tB-ORG\npilot\tO\nblamed\tO\nTurkish\tB-MISC\nairport\tO\nstaff\tO\nfor\tO\nmisleading\tO\nhim\tO\n.\tO\n\nThat\tO\n's\tO\nwrong\tO\n,\tO\n\"\tO\nthe\tO\npilot\tO\ntold\tO\nprivate\tO\nIhlas\tB-ORG\nnews\tO\nagency\tO\nin\tO\nEnglish\tB-MISC\n.\tO\n\nEgypt\tB-LOC\nwants\tO\nnothing\tO\nto\tO\ndo\tO\nwith\tO\nSudanese\tB-MISC\nrulers\tO\n.\tO\n\nThe\tO\nEgyptian\tB-MISC\ngovernment\tO\nwill\tO\nhave\tO\nnothing\tO\nmore\tO\nto\tO\ndo\tO\nwith\tO\nthe\tO\nSudanese\tB-MISC\ngovernment\tO\nbecause\tO\nit\tO\ncontinues\tO\nto\tO\nshelter\tO\nand\tO\nsupport\tO\nEgyptian\tB-MISC\nmilitants\tO\n,\tO\nPresident\tO\nHosni\tB-PER\nMubarak\tI-PER\nsaid\tO\nin\tO\na\tO\nspeech\tO\non\tO\nThursday\tO\n.\tO\n\nEgypt\tB-LOC\nsays\tO\nthe\tO\nSudanese\tB-MISC\ngovernment\tO\nhelped\tO\nthe\tO\nMoslem\tB-MISC\nmilitants\tO\nwho\tO\ntried\tO\nto\tO\nkill\tO\nMubarak\tB-PER\nin\tO\nAddis\tB-LOC\nAbaba\tI-LOC\nlast\tO\nyear\tO\n.\tO\n\nIt\tO\nsponsored\tO\nlast\tO\nweek\tO\n's\tO\nU.N.\tB-ORG\nSecurity\tI-ORG\nCouncil\tI-ORG\nresolution\tO\nthreatening\tO\na\tO\nban\tO\non\tO\nSudanese\tB-MISC\nflights\tO\nabroad\tO\nif\tO\nKhartoum\tB-LOC\ndoes\tO\nnot\tO\nhand\tO\nover\tO\nthree\tO\nmen\tO\naccused\tO\nin\tO\nthe\tO\nAddis\tB-LOC\nAbaba\tI-LOC\nincident\tO\n.\tO\n\nThe\tO\nsanctions\tO\nwill\tO\ncome\tO\ninto\tO\neffect\tO\nin\tO\nNovember\tO\nif\tO\nSudan\tB-LOC\nfails\tO\nto\tO\nextradite\tO\nthe\tO\nmen\tO\n,\tO\nbut\tO\nSudan\tB-LOC\nsays\tO\nit\tO\ncannot\tO\nhand\tO\nthem\tO\nover\tO\nto\tO\nEthiopia\tB-LOC\nfor\tO\ntrial\tO\nbecause\tO\nthey\tO\nare\tO\nnot\tO\nin\tO\nSudan\tB-LOC\n.\tO\n\n\"\tO\nWe\tO\nare\tO\nstill\tO\neager\tO\nthat\tO\nnothing\tO\nshould\tO\naffect\tO\nthe\tO\nSudanese\tB-MISC\npeople\tO\nbut\tO\nwe\tO\nwill\tO\nnot\tO\ndeal\tO\nwith\tO\nthe\tO\ncurrent\tO\nregime\tO\nor\tO\nthe\tO\nTurabi\tB-PER\nfront\tO\nor\tO\nwhatever\tO\n,\tO\n\"\tO\nMubarak\tB-PER\ntold\tO\na\tO\ngroup\tO\nof\tO\nacademics\tO\n.\tO\n\nHassan\tB-PER\nal-Turabi\tI-PER\nis\tO\nthe\tO\nleader\tO\nof\tO\nthe\tO\nNational\tB-ORG\nIslamic\tI-ORG\nFront\tI-ORG\n,\tO\nthe\tO\npolitical\tO\nforce\tO\nbehind\tO\nthe\tO\nSudanese\tB-MISC\ngovernment\tO\n.\tO\n\nThere\tO\nare\tO\nterrorists\tO\nthey\tO\nare\tO\nsheltering\tO\nand\tO\nthey\tO\nmake\tO\nSudanese\tB-MISC\npassorts\tO\nfor\tO\nthem\tO\nand\tO\nthey\tO\nget\tO\npaid\tO\nby\tO\nthem\tO\n,\tO\n\"\tO\nMubarak\tB-PER\nsaid\tO\n.\tO\n\nHe\tO\ndid\tO\nnot\tO\nsay\tO\nif\tO\nEgypt\tB-LOC\nwould\tO\ngo\tO\nso\tO\nfar\tO\nas\tO\nto\tO\nbreak\tO\nrelations\tO\n,\tO\na\tO\nstep\tO\nit\tO\nhas\tO\nbeen\tO\nreluctant\tO\nto\tO\ntake\tO\n,\tO\nostensibly\tO\nbecause\tO\nit\tO\nwould\tO\naffect\tO\nordinary\tO\nSudanese\tB-MISC\n.\tO\n\nTurkish\tB-MISC\nshares\tO\nshed\tO\ngains\tO\nin\tO\nprofit-taking\tO\n.\tO\n\nTurkish\tB-MISC\nshares\tO\nended\tO\nlower\tO\non\tO\nThursday\tO\n,\tO\nshedding\tO\ngains\tO\nof\tO\nearlier\tO\nin\tO\nthe\tO\nweek\tO\namid\tO\nprofit-taking\tO\nsales\tO\n,\tO\nbrokers\tO\nsaid\tO\n.\tO\n\nThe\tO\nIMKB-100\tB-MISC\nlost\tO\n0.19\tO\npercent\tO\nor\tO\n123.89\tO\npoints\tO\nto\tO\nend\tO\nat\tO\n64,178.78\tO\n.\tO\n\nI\tO\nexpect\tO\nthe\tO\nmarket\tO\nto\tO\ngo\tO\nas\tO\nfar\tO\ndown\tO\nas\tO\n63,000\tO\ntomorrow\tO\nif\tO\nsales\tO\ncontinue\tO\n,\tO\n\"\tO\nsaid\tO\nBurcin\tB-PER\nMavituna\tI-PER\nfrom\tO\nInterbank\tB-ORG\n.\tO\n\nThe\tO\nsession\tO\n's\tO\nmost\tO\nactive\tO\nshares\tO\nwere\tO\nthose\tO\nof\tO\nIsbank\tB-ORG\ngained\tO\n300\tO\nlira\tO\nto\tO\n8,600\tO\n.\tO\n\nShares\tO\nof\tO\nutility\tO\nCukurova\tB-ORG\nlost\tO\n3,000\tO\nlira\tO\nto\tO\n67,000\tO\n.\tO\n\n--\tO\nIstanbul\tB-ORG\nNewsroom\tI-ORG\n,\tO\n+90-212-275\tO\n0875\tO\nSA\tO\n\nMiss\tB-MISC\nUniverse\tI-MISC\nhides\tO\nbehind\tO\nveil\tO\nof\tO\nsilence\tO\n.\tO\n\nMiss\tB-MISC\nUniverse\tI-MISC\n,\tO\nVenezuela\tB-LOC\n's\tO\nAlicia\tB-PER\nMachado\tI-PER\n,\tO\nleft\tO\nNew\tO\nMexico\tO\non\tO\nThursday\tO\n,\tO\nrefusing\tO\nto\tO\nanswer\tO\nquestions\tO\nabout\tO\nher\tO\nweight\tO\nor\tO\nclaims\tO\nshe\tO\nwas\tO\ntold\tO\nto\tO\neither\tO\ngo\tO\non\tO\na\tO\ncrash\tO\ndiet\tO\nor\tO\ngive\tO\nup\tO\nher\tO\ntitle\tO\n.\tO\n\nMachado\tB-PER\n,\tO\n19\tO\n,\tO\nflew\tO\nto\tO\nLos\tB-LOC\nAngeles\tI-LOC\nafter\tO\nslipping\tO\naway\tO\nfrom\tO\nthe\tO\nNew\tB-LOC\nMexico\tI-LOC\ndesert\tO\ntown\tO\nof\tO\nLas\tB-LOC\nCruces\tI-LOC\n,\tO\nwhere\tO\nshe\tO\nattended\tO\nthe\tO\n1996\tB-MISC\nMiss\tI-MISC\nTeen\tI-MISC\nUSA\tI-MISC\npageant\tO\non\tO\nWednesday\tO\n.\tO\n\nWhile\tO\nMachado\tB-PER\nwas\tO\nnot\tO\na\tO\ncontestant\tO\nhere\tO\n,\tO\nshe\tO\ncame\tO\nunder\tO\nintense\tO\nscrutiny\tO\nfollowing\tO\nreports\tO\nshe\tO\nwas\tO\ngiven\tO\nan\tO\nultimatum\tO\nby\tO\nLos\tB-MISC\nAngeles-based\tI-MISC\nMiss\tB-ORG\nUniverse\tI-ORG\nInc.\tI-ORG\nto\tO\ndrop\tO\n27\tO\npounds\tO\n(\tO\n12\tO\nkg\tO\n)\tO\nin\tO\ntwo\tO\nweeks\tO\nor\tO\nrisk\tO\nlosing\tO\nher\tO\ncrown\tO\n.\tO\n\nIn\tO\nVenezuela\tB-LOC\n,\tO\nher\tO\nmother\tO\ntold\tO\nReuters\tB-ORG\nthat\tO\nMachado\tB-PER\nhad\tO\na\tO\nswollen\tO\nface\tO\nwhen\tO\nshe\tO\nleft\tO\nhome\tO\ntwo\tO\nweeks\tO\nago\tO\nbecause\tO\nshe\tO\nhad\tO\nher\tO\nwisdom\tO\nteeth\tO\nextracted\tO\n.\tO\n\nMarta\tB-PER\nFajardo\tI-PER\ninsisted\tO\nher\tO\ndaughter\tO\n,\tO\nwho\tO\nweighed\tO\n112\tO\npounds\tO\n(\tO\n51\tO\nkg\tO\n)\tO\nwhen\tO\nshe\tO\nwon\tO\nthe\tO\nMiss\tB-MISC\nUniverse\tI-MISC\ntitle\tO\nin\tO\nLas\tB-LOC\nVegas\tI-LOC\nin\tO\nMay\tO\n,\tO\nhad\tO\nperfectly\tO\nnormal\tO\neating\tO\nhabits\tO\n.\tO\n\nOrganisers\tO\nflatly\tO\ndenied\tO\never\tO\nthreatening\tO\nMachado\tB-PER\nbut\tO\nimmediately\tO\nput\tO\nher\tO\nunder\tO\nwraps\tO\nand\tO\nblocked\tO\naccess\tO\nto\tO\nher\tO\n.\tO\n\nDressed\tO\nin\tO\na\tO\nblack\tO\nstrapless\tO\nevening\tO\ngown\tO\nat\tO\nWednesday\tO\n's\tO\npageant\tO\n,\tO\nMachado\tB-PER\nwas\tO\nclearly\tO\nheavier\tO\nthan\tO\nthe\tO\ncontestants\tO\nbut\tO\nstill\tO\nwon\tO\nrave\tO\nreviews\tO\nafter\tO\nher\tO\nbrief\tO\nappearance\tO\non\tO\nstage\tO\n.\tO\n\nShe\tO\n's\tO\nfantastic\tO\n,\tO\n\"\tO\nsaid\tO\nNikki\tB-PER\nCampbell\tI-PER\n,\tO\n28\tO\n,\tO\nwho\tO\nwent\tO\nto\tO\nthe\tO\npageant\tO\n.\tO\n\"\tO\n\nMachado\tB-PER\n's\tO\npublicists\tO\nsaid\tO\non\tO\nThursday\tO\nshe\tO\nwas\tO\nscheduled\tO\nto\tO\nstay\tO\nin\tO\nLos\tB-LOC\nAngeles\tI-LOC\nfor\tO\npromotional\tO\nwork\tO\nwith\tO\nsponsors\tO\nbefore\tO\nreturning\tO\nto\tO\nVenezuela\tB-LOC\non\tO\nSept\tO\n.\tO\n\nBeauty\tO\nqueens\tO\nare\tO\nhigh-profile\tO\npersonalities\tO\nin\tO\nVenezuela\tB-LOC\nand\tO\nMachado\tB-PER\n's\tO\nalleged\tO\nweight\tO\nproblem\tO\nmade\tO\nfront\tO\npage\tO\nnews\tO\nthis\tO\nweek\tO\n.\tO\n\nIt\tO\nwas\tO\nan\tO\nofficial\tO\nof\tO\nthe\tO\nMiss\tB-ORG\nVenezuela\tI-ORG\nOrganisation\tI-ORG\nwho\tO\nfirst\tO\nsaid\tO\nMachado\tB-PER\nhad\tO\nbeen\tO\ntold\tO\nto\tO\nlose\tO\nweight\tO\nfast\tO\n.\tO\n\nMartin\tB-PER\nBrooks\tI-PER\n,\tO\npresident\tO\nof\tO\nMiss\tB-ORG\nUniverse\tI-ORG\nInc\tI-ORG\n,\tO\nsaid\tO\nhe\tO\nspoke\tO\nwith\tO\nMachado\tB-PER\nto\tO\nassure\tO\nher\tO\nthat\tO\norganisers\tO\nwere\tO\nnot\tO\nputting\tO\npressure\tO\non\tO\nher\tO\n.\tO\n\nHe\tO\nsaid\tO\nthe\tO\nlifestyle\tO\nassociated\tO\nwith\tO\nbeing\tO\nMiss\tB-MISC\nUniverse\tI-MISC\ncould\tO\nmake\tO\nroutine\tO\nexercise\tO\ndifficult\tO\n.\tO\n\nI\tO\ndont\tO\nknow\tO\nif\tO\nAlicia\tB-PER\nis\tO\nworking\tO\nout\tO\n.\tO\n\nKevorkian\tB-PER\nattends\tO\nthird\tO\nsuicide\tO\nin\tO\nweek\tO\n.\tO\n\nPONTIAC\tB-LOC\n,\tO\nMich\tB-LOC\n.\tO\n\nDr.\tO\nJack\tB-PER\nKevorkian\tI-PER\nattended\tO\nhis\tO\nthird\tO\nsuicide\tO\nin\tO\nless\tO\nthan\tO\na\tO\nweek\tO\non\tO\nThursday\tO\n,\tO\nbringing\tO\nthe\tO\nbody\tO\nof\tO\na\tO\n40-year-old\tO\nMissouri\tB-LOC\nwoman\tO\nsuffering\tO\nfrom\tO\nmultiple\tO\nsclerosis\tO\nto\tO\na\tO\nhospital\tO\nemergency\tO\nroom\tO\n,\tO\ndoctors\tO\nsaid\tO\n.\tO\n\nDr\tO\nRobert\tB-PER\nAranosian\tI-PER\n,\tO\nemergency\tO\nroom\tO\ndirector\tO\nat\tO\nPontiac\tB-LOC\nOsteopathic\tI-LOC\nHospital\tI-LOC\n,\tO\nsaid\tO\nKevorkian\tB-PER\nbrought\tO\nin\tO\nthe\tO\nbody\tO\nof\tO\nPatricia\tB-PER\nSmith\tI-PER\n,\tO\nof\tO\nLees\tB-LOC\nSummit\tI-LOC\n,\tO\nMo\tB-LOC\n.\tO\n\nKevorkian\tB-PER\n's\tO\nlawyer\tO\n,\tO\nGeoffrey\tB-PER\nFieger\tI-PER\n,\tO\nsaid\tO\nthose\tO\nattending\tO\nSmith\tB-PER\n's\tO\ndeath\tO\nincluded\tO\nher\tO\nhusband\tO\n,\tO\nDavid\tB-PER\n,\tO\na\tO\npolice\tO\nofficer\tO\n,\tO\nher\tO\nfather\tO\n,\tO\nJames\tB-PER\nPoland\tI-PER\n,\tO\nand\tO\nKevorkian\tB-PER\n.\tO\n\nIt\tO\nwas\tO\nthe\tO\nfirst\tO\nknown\tO\ntime\tO\nthat\tO\na\tO\npolice\tO\nofficer\tO\nhas\tO\nbeen\tO\npresident\tO\nat\tO\nthe\tO\nsuicide\tO\nof\tO\none\tO\nof\tO\nKevorkian\tB-PER\n's\tO\npatients\tO\n.\tO\n\nHe\tO\noffered\tO\nno\tO\ndetails\tO\nabout\tO\nthe\tO\ncause\tO\nof\tO\nSmith\tB-PER\n's\tO\ndeath\tO\nor\tO\nthe\tO\nlocation\tO\n.\tO\n\nOn\tO\nTuesday\tO\nnight\tO\n,\tO\nKevorkian\tB-PER\nattended\tO\nthe\tO\ndeath\tO\nof\tO\nLouise\tB-PER\nSiebens\tI-PER\n,\tO\na\tO\n76-year-old\tO\nTexas\tB-LOC\nwoman\tO\nwith\tO\namyotrophic\tO\nlateral\tO\nsclerosis\tO\n,\tO\nor\tO\nLou\tB-PER\nGehrig\tI-PER\n's\tO\ndisease\tO\n.\tO\n\nOn\tO\nAugust\tO\n15\tO\n,\tO\nKevorkian\tB-PER\nhelped\tO\nJudith\tB-PER\nCurren\tI-PER\n,\tO\na\tO\n42-year-old\tO\nMassachusetts\tB-LOC\nnurse\tO\n,\tO\nwho\tO\nsuffered\tO\nfrom\tO\nchronic\tO\nfatigue\tO\nsyndrome\tO\n,\tO\na\tO\nnon-terminal\tO\nillness\tO\n,\tO\nto\tO\nend\tO\nher\tO\nlife\tO\n.\tO\n\nFairview\tB-LOC\n,\tO\nTexas\tB-LOC\n,\tO\n$\tO\n1.82\tO\nmillion\tO\ndeal\tO\nBaa1\tO\n-\tO\nMoody\tB-ORG\n's\tI-ORG\n.\tO\n\nIssuer\tO\n:\tO\nFairview\tB-LOC\nTown\tI-LOC\n\nState\tO\n:\tO\nTX\tB-LOC\n\nDefiant\tO\nU.S.\tB-LOC\nneo-Nazi\tO\njailed\tO\nby\tO\nGerman\tO\ncourt\tO\n.\tO\n\nHAMBURG\tB-LOC\n,\tO\nGermany\tB-LOC\n1996-08-22\tO\n\nA\tO\nHamburg\tB-LOC\ncourt\tO\nsentenced\tO\nU.S.\tB-LOC\nneo-Nazi\tB-MISC\nleader\tO\nGary\tB-PER\nLauck\tI-PER\non\tO\nThursday\tO\nto\tO\nfour\tO\nyears\tO\nin\tO\nprison\tO\nfor\tO\npumping\tO\nbanned\tO\nextremist\tO\npropaganda\tO\ninto\tO\nGermany\tB-LOC\nfrom\tO\nhis\tO\nbase\tO\nin\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\n.\tO\n\nLauck\tB-PER\n,\tO\nfrom\tO\nLincoln\tB-LOC\n,\tO\nNebraska\tB-LOC\n,\tO\nyelled\tO\na\tO\ntirade\tO\nof\tO\nabuse\tO\nat\tO\nthe\tO\ncourt\tO\nafter\tO\nhis\tO\nconviction\tO\nfor\tO\ninciting\tO\nracial\tO\nhatred\tO\n.\tO\n\n\"\tO\nThe\tO\nstruggle\tO\nwill\tO\ngo\tO\non\tO\n,\tO\n\"\tO\nthe\tO\n43-year-old\tO\nshouted\tO\nin\tO\nGerman\tB-MISC\nbefore\tO\nbeing\tO\nescorted\tO\nout\tO\nby\tO\nsecurity\tO\nguards\tO\n.\tO\n\nLauck\tB-PER\n's\tO\nlawyer\tO\nvowed\tO\nhe\tO\nwould\tO\nappeal\tO\nagainst\tO\nthe\tO\ncourt\tO\n's\tO\ndecision\tO\n,\tO\narguing\tO\nthat\tO\nhis\tO\nclient\tO\nshould\tO\nhave\tO\nbeen\tO\nset\tO\nfree\tO\nbecause\tO\nhe\tO\nhad\tO\nnot\tO\ncommitted\tO\nany\tO\noffence\tO\nunder\tO\nGerman\tB-MISC\nlaw\tO\n.\tO\n\nThe\tO\nGerman\tB-MISC\ngovernment\tO\nhailed\tO\nthe\tO\nconviction\tO\nas\tO\na\tO\nmajor\tO\nvictory\tO\nin\tO\nthe\tO\nfight\tO\nagainst\tO\nneo-Nazism\tB-MISC\n.\tO\n\nLauck\tB-PER\n's\tO\nworldwide\tO\nnetwork\tO\nhas\tO\nbeen\tO\nthe\tO\nmain\tO\nsource\tO\nof\tO\nanti-Semitic\tB-MISC\npropaganda\tO\nmaterial\tO\nflowing\tO\ninto\tO\nGermany\tB-LOC\nsince\tO\nthe\tO\n1970s\tO\n.\tO\n\n\"\tO\nLauck\tB-PER\npossessed\tO\na\tO\nwell-oiled\tO\npropaganda\tO\nmachine\tO\n,\tO\nhoned\tO\nduring\tO\nmore\tO\nthan\tO\n20\tO\nyears\tO\n,\tO\n\"\tO\npresiding\tO\njudge\tO\nGuenter\tB-PER\nBertram\tI-PER\ntold\tO\nthe\tO\ncourt\tO\n.\tO\n\n\"\tO\nHe\tO\nset\tO\nup\tO\na\tO\npropaganda\tO\ncannon\tO\nand\tO\nfired\tO\nit\tO\nat\tO\nGermany\tB-LOC\n.\tO\n\"\tO\n\nsaid\tO\nBertram\tB-PER\n,\tO\nwho\tO\nalso\tO\nread\tO\nout\tO\nextracts\tO\nfrom\tO\nLauck\tB-PER\n's\tO\nmaterial\tO\npraising\tO\nHitler\tB-PER\nas\tO\n\"\tO\nthe\tO\ngreatest\tO\nof\tO\nall\tO\nleaders\tO\n\"\tO\nand\tO\ndescribing\tO\nthe\tO\nNazi\tB-MISC\nslaughter\tO\nof\tO\nmillions\tO\nof\tO\nJews\tB-MISC\nas\tO\na\tO\nmyth\tO\n.\tO\n\nEager\tO\nto\tO\nput\tO\nLauck\tB-PER\nbehind\tO\nbars\tO\nquickly\tO\nand\tO\navoid\tO\na\tO\nlong\tO\nand\tO\ncomplex\tO\ntrial\tO\n,\tO\nprosecutor\tO\nBernd\tB-PER\nMauruschat\tI-PER\nlimited\tO\nhis\tO\ncharges\tO\nto\tO\noffences\tO\nsince\tO\n1994\tO\n.\tO\n\nPublishing\tO\nand\tO\ndistributing\tO\nneo-Nazi\tB-MISC\nmaterial\tO\nis\tO\nillegal\tO\nin\tO\nGermany\tB-LOC\nbut\tO\nLauck\tB-PER\n's\tO\ndefence\tO\nteam\tO\nhad\tO\nargued\tO\nthat\tO\nU.S\tB-LOC\nfreedom\tO\nof\tO\nspeech\tO\nlaws\tO\nmeant\tO\nhe\tO\nwas\tO\nfree\tO\nto\tO\nproduce\tO\nhis\tO\nswastika-covered\tO\nbooks\tO\n,\tO\nmagazines\tO\n,\tO\nvideos\tO\nand\tO\nflags\tO\nin\tO\nhis\tO\nhomeland\tO\n.\tO\n\nInterior\tO\nMinister\tO\nManfred\tB-PER\nKanther\tI-PER\nsaid\tO\nin\tO\na\tO\nstatement\tO\nhe\tO\n\"\tO\nwelcomed\tO\nthe\tO\nprosecution\tO\nand\tO\nconviction\tO\nof\tO\none\tO\nof\tO\nthe\tO\nringleaders\tO\nof\tO\ninternational\tO\nneo-Nazism\tB-MISC\nand\tO\nbiggest\tO\ndistributers\tO\nof\tO\nvicious\tO\nracist\tO\npublications\tO\n\"\tO\n.\tO\n\n\"\tO\nIt\tO\nis\tO\nhigh\tO\ntime\tO\nhe\tO\nwas\tO\nbehind\tO\nbars\tO\n,\tO\n\"\tO\nthe\tO\nopposition\tO\nSocial\tB-MISC\nDemocrats\tI-MISC\nsaid\tO\nin\tO\na\tO\nstatement\tO\n.\tO\n\nLauck\tB-PER\n,\tO\ndressed\tO\nin\tO\na\tO\nsober\tO\nblue\tO\nsuit\tO\nand\tO\nsporting\tO\nhis\tO\ntrademark\tO\nHitleresque\tB-MISC\nblack\tO\nmoustache\tO\n,\tO\nshowed\tO\nno\tO\nsign\tO\nof\tO\nemotion\tO\nas\tO\nBertram\tB-PER\nspent\tO\nmore\tO\nthan\tO\nan\tO\nhour\tO\nreading\tO\nout\tO\nthe\tO\nverdict\tO\nand\tO\nexplaining\tO\nthe\tO\ncourt\tO\n's\tO\ndecision\tO\n.\tO\n\nBut\tO\nas\tO\nLauck\tB-PER\nwas\tO\nabout\tO\nto\tO\nbe\tO\nled\tO\naway\tO\n,\tO\nhe\tO\nturned\tO\nto\tO\nreporters\tO\nand\tO\nblurted\tO\nout\tO\na\tO\nvirtually\tO\nincomprehensible\tO\nquick-fire\tO\ndiatribe\tO\nagainst\tO\nthe\tO\ncourt\tO\n.\tO\n\n\"\tO\nNeither\tO\nthe\tO\nNational\tB-MISC\nSocialists\tI-MISC\n(\tO\nNazis\tB-MISC\n)\tO\nnor\tO\nthe\tO\ncommunists\tO\ndared\tO\nto\tO\nkidnap\tO\nan\tO\nAmerican\tB-MISC\ncitizen\tO\n,\tO\n\"\tO\nhe\tO\nshouted\tO\n,\tO\nin\tO\nan\tO\noblique\tO\nreference\tO\nto\tO\nhis\tO\nextradition\tO\nto\tO\nGermany\tB-LOC\nfrom\tO\nDenmark\tB-LOC\n.\tO\n\"\tO\n\nHis\tO\nattorney\tO\n,\tO\nHans-Otto\tB-PER\nSieg\tI-PER\n,\tO\ntold\tO\nreporters\tO\noutside\tO\nthe\tO\ncourtroom\tO\nthat\tO\nthe\tO\njudges\tO\nhad\tO\nnot\tO\nexplained\tO\nhow\tO\na\tO\nGerman\tB-MISC\ncourt\tO\ncould\tO\njudge\tO\nsomeone\tO\nfor\tO\nactions\tO\ncarried\tO\nout\tO\nin\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\n.\tO\n\nBertram\tB-PER\nsaid\tO\nLauck\tB-PER\nwas\tO\nobsessed\tO\nby\tO\nNazism\tB-MISC\nand\tO\ndevoted\tO\nhis\tO\nlife\tO\nto\tO\nleading\tO\nhis\tO\nNational\tB-ORG\nSocialist\tI-ORG\nGerman\tI-ORG\nWorkers\tI-ORG\n'\tI-ORG\nParty\tI-ORG\nForeign\tI-ORG\nOrganisation\tI-ORG\n(\tO\nNSDAP-AO\tB-ORG\n)\tO\n,\tO\nwhich\tO\nderives\tO\nits\tO\nname\tO\nfrom\tO\nthe\tO\nfull\tO\nGerman\tB-MISC\ntitle\tO\nof\tO\nHitler\tB-PER\n's\tO\nNazi\tB-MISC\nparty\tO\n.\tO\n\nDuring\tO\nthe\tO\nthree-month\tO\ntrial\tO\n,\tO\nthe\tO\ncourt\tO\ndealt\tO\nmainly\tO\nwith\tO\nissues\tO\nof\tO\nthe\tO\nNSDAP-AO\tB-ORG\n's\tO\n\"\tO\nNS\tB-ORG\nKampfruf\tI-ORG\n\"\tO\n(\tO\n\"\tO\nNational\tB-ORG\nSocialist\tI-ORG\nBattle\tI-ORG\nCry\tI-ORG\n\"\tO\n)\tO\nmagazine\tO\n,\tO\nfilled\tO\nwith\tO\nreferences\tO\nto\tO\nAryan\tB-MISC\nsupremacy\tO\nand\tO\ndefamatory\tO\nstatements\tO\nabout\tO\nJews\tB-MISC\n.\tO\n\nThe\tO\ncourt\tO\nrejected\tO\nSieg\tB-PER\n's\tO\nargument\tO\nthat\tO\nLauck\tB-PER\n's\tO\nextradition\tO\nfrom\tO\nDenmark\tB-LOC\n,\tO\nwhere\tO\nhe\tO\nwas\tO\narrested\tO\nin\tO\nMarch\tO\nlast\tO\nyear\tO\nat\tO\nthe\tO\nrequest\tO\nof\tO\nGerman\tB-MISC\nauthorities\tO\n,\tO\nwas\tO\nillegal\tO\n.\tO\n\nLauck\tB-PER\nwas\tO\nalso\tO\nconvicted\tO\nof\tO\ndisseminating\tO\nthe\tO\nsymbols\tO\nof\tO\nanti-constitutional\tO\norganisations\tO\n.\tO\n\nUN\tO\nofficial\tO\nsays\tO\nIraqi\tB-MISC\ndeal\tO\nwill\tO\noccur\tO\n\"\tO\nsoon\tO\n\"\tO\n.\tO\n\nA\tO\nsenior\tO\nU.N.\tB-ORG\nofficial\tO\nsaid\tO\non\tO\nThursday\tO\nhe\tO\nexpected\tO\narrangements\tO\nto\tO\nimplement\tO\nthe\tO\nIraqi\tB-MISC\noil-for-food\tO\ndeal\tO\ncould\tO\nbe\tO\ncompleted\tO\n\"\tO\nquite\tO\nsoon\tO\n.\tO\n\"\tO\n\n\"\tO\nI\tO\nam\tO\nreluctant\tO\nto\tO\nspeculate\tO\nbut\tO\nwe\tO\nare\tO\ndoing\tO\nthe\tO\npreparations\tO\nand\tO\nthe\tO\nsecretary-general\tO\nis\tO\nanxious\tO\nto\tO\nstart\tO\nthe\tO\nprogram\tO\n,\tO\n\"\tO\nsaid\tO\nUndersecretary-General\tO\nYasushi\tB-PER\nAkashi\tI-PER\n.\tO\n\n\"\tO\nIt\tO\nmight\tO\nbe\tO\nsooner\tO\nthan\tO\nyou\tO\nthink\tO\n,\tO\n\"\tO\nhe\tO\ntold\tO\nreporters\tO\nafter\tO\nbriefing\tO\nthe\tO\nSecurity\tB-ORG\nCouncil\tI-ORG\non\tO\narrangements\tO\nfor\tO\nmonitors\tO\nneeded\tO\nto\tO\ncarry\tO\nout\tO\nthe\tO\nagreement\tO\n.\tO\n\nAkashi\tB-PER\nis\tO\nhead\tO\nof\tO\nthe\tO\nDepartment\tB-ORG\nof\tI-ORG\nHumanitarian\tI-ORG\naffairs\tI-ORG\n.\tO\n\nSuspected\tO\nkillers\tO\nof\tO\nbishop\tO\ndead\tO\n--\tO\nAlgeria\tB-ORG\nTV\tI-ORG\n.\tO\n\nAlgerian\tB-MISC\nsecurity\tO\nforces\tO\nhave\tO\nshot\tO\ndead\tO\nthree\tO\nMoslem\tB-MISC\nguerrillas\tO\nsuspected\tO\nof\tO\nkilling\tO\na\tO\nleading\tO\nFrench\tB-MISC\nbishop\tO\nin\tO\nwestern\tO\nAlgeria\tB-LOC\n,\tO\nthe\tO\nAlgerian\tB-MISC\nstate-run\tO\ntelevision\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nSecurity\tO\nforces\tO\nalso\tO\narrested\tO\nfour\tO\nother\tO\nmen\tO\nsought\tO\nfor\tO\ngiving\tO\nsupport\tO\nto\tO\nthe\tO\nslain\tO\nMoslem\tB-MISC\nrebels\tO\n,\tO\nthe\tO\ntelevision\tO\nsaid\tO\n.\tO\n\nThe\tO\ntelevision\tO\n,\tO\nwhich\tO\ndid\tO\nnot\tO\nsay\tO\nwhen\tO\nthe\tO\nsecurity\tO\nforces\tO\nkilled\tO\nthe\tO\nrebels\tO\n,\tO\nsaid\tO\nthe\tO\nfour\tO\narrested\tO\nmen\tO\nconfessed\tO\ndetails\tO\nof\tO\nthe\tO\nassassination\tO\nof\tO\nthe\tO\nFrench\tB-MISC\nRoman\tB-MISC\nCatholic\tI-MISC\nBishop\tO\nPierre\tO\nClaverie\tO\n.\tO\n\nThe\tO\n58-year-old\tO\nClaverie\tB-PER\nwas\tO\nkilled\tO\nin\tO\nAugust\tO\n1\tO\nin\tO\na\tO\nbomb\tO\nblast\tO\nat\tO\nhis\tO\nresidence\tO\nin\tO\nthe\tO\nwestern\tO\nAlgerian\tB-MISC\ncity\tO\nof\tO\nOran\tB-LOC\n,\tO\nhours\tO\nafter\tO\nhe\tO\nmet\tO\nvisiting\tO\nFrench\tB-MISC\nForeign\tO\nMinister\tO\nHerve\tB-PER\nde\tI-PER\nCharette\tI-PER\nin\tO\nAlgiers\tB-LOC\n.\tO\n\nAn\tO\nestimated\tO\n50,000\tO\nAlgerians\tB-MISC\nand\tO\nmore\tO\nthan\tO\n110\tO\nforeigners\tO\nhave\tO\nbeen\tO\nkilled\tO\nin\tO\nAlgeria\tB-LOC\n's\tO\nviolence\tO\npitting\tO\nMoslem\tB-MISC\nrebels\tO\nagainst\tO\nthe\tO\nAlgerian\tB-MISC\ngovernment\tO\nforces\tO\nsince\tO\nearly\tO\n1992\tO\n,\tO\nwhen\tO\nthe\tO\nauthorities\tO\ncancelled\tO\na\tO\ngeneral\tO\nelection\tO\nin\tO\nwhich\tO\nradical\tO\nIslamists\tB-MISC\ntook\tO\na\tO\ncommanding\tO\nlead\tO\n.\tO\n\nGerman\tB-MISC\nflown\tO\ncargo\tO\nJanuary-July\tO\nrise\tO\n3.8\tO\npercent\tO\n.\tO\n\nThe\tO\nfollowing\tO\ntable\tO\nshows\tO\ntotal\tO\nflown\tO\nair\tO\ncargo\tO\nvolumes\tO\nin\tO\ntonnes\tO\nhandled\tO\nat\tO\ninternational\tO\nGerman\tB-MISC\nairports\tO\nJanuary-July\tO\n1996\tO\n.\tO\n\nThe\tO\nfigures\tO\nexclude\tO\ntrucked\tO\nairfreight\tO\naccording\tO\nto\tO\nthe\tO\nGerman\tB-MISC\nairports\tO\nassociation\tO\nADV\tO\n.\tO\n\n-\tO\nTegel\tB-LOC\n10,896\tO\nup\tO\n3.1\tO\n\n-\tO\nTempelhof\tB-LOC\n202\tO\ndown\tO\n60.0\tO\n\nBremen\tB-LOC\n1,453\tO\nup\tO\n13.1\tO\n\nDresden\tB-LOC\n792\tO\nup\tO\n11.4\tO\n\nDuessseldorf\tB-LOC\n31,347\tO\ndown\tO\n4.4\tO\n\nHamburg\tB-LOC\n21,240\tO\ndown\tO\n3.5\tO\n\nKoeln\tB-LOC\n(\tO\nCologne\tB-LOC\n)\tO\n182,887\tO\nup\tO\n11.8\tO\n\nLeipzig\tB-LOC\n/\tO\nHalle\tB-LOC\n1,806\tO\nup\tO\n45.6\tO\n\nMunich\tB-LOC\n44,525\tO\nup\tO\n11.8\tO\n\nMuenster\tB-LOC\n/\tO\nOsnabrueck\tB-LOC\n382\tO\nup\tO\n28.2\tO\n\nSaarbruecken\tB-LOC\n626\tO\nup\tO\n28.3\tO\n\nStuttgart\tB-LOC\n10,655\tO\nup\tO\n11.7\tO\n\n-\tO\nAir\tB-ORG\nCargo\tI-ORG\nNewsroom\tI-ORG\nTel+44\tO\n161\tO\n542\tO\n7706\tO\nFax+44\tO\n171\tO\n542\tO\n5017\tO\n\nParibas\tB-ORG\nrepeats\tO\nbuy\tO\non\tO\nAegon\tB-ORG\nafter\tO\nresults\tO\n.\tO\n\nAegon\tO\n83.40\tO\nParibas\tB-ORG\n\nCOMMENT\tO\n:\tO\n\"\tO\nNot\tO\nonly\tO\ndid\tO\nAegon\tB-ORG\nsurprise\tO\nwith\tO\nearnings\tO\nof\tO\n711\tO\nmillion\tO\nguilders\tO\n,\tO\nwhich\tO\nwere\tO\nabove\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nexpected\tO\nrange\tO\n,\tO\nit\tO\nalso\tO\nforecast\tO\na\tO\nsimilar\tO\nperformance\tO\nin\tO\nthe\tO\nsecond\tO\nhalf\tO\n.\tO\n\"\tO\n\nEstimates\tO\n(\tO\nDfl\tB-MISC\n)\tO\n:\tO\nEPS\tO\nP\tO\n/\tO\nE\tO\nDividend\tO\n\nClinton\tB-PER\n's\tO\nBallybunion\tB-ORG\nfans\tO\ninvited\tO\nto\tO\nChicago\tB-LOC\n.\tO\n\nU.S.\tB-LOC\nPresident\tO\nBill\tB-PER\nClinton\tI-PER\nhad\tO\nto\tO\ndrop\tO\nthe\tO\nresort\tO\nof\tO\nBallybunion\tB-ORG\nfrom\tO\na\tO\nwhirlwind\tO\nIrish\tB-MISC\ntour\tO\nlast\tO\nyear\tO\n.\tO\n\nSo\tO\nBallybunion\tB-ORG\nis\tO\ngoing\tO\nto\tO\nAmerica\tO\ninstead\tO\n.\tO\n\nTwo\tO\nresidents\tO\nof\tO\nthe\tO\nAtlantic\tB-LOC\nresort\tO\n,\tO\nwhere\tO\nClinton\tB-PER\nwas\tO\nto\tO\nhave\tO\nplayed\tO\ngolf\tO\nwith\tO\nthe\tO\nIrish\tB-MISC\nForeign\tO\nMinister\tO\nDick\tB-PER\nSpring\tI-PER\n,\tO\nhave\tO\nbeen\tO\ninvited\tO\nto\tO\nthe\tO\nDemocratic\tB-MISC\nparty\tO\nconvention\tO\nin\tO\nChicago\tB-LOC\non\tO\nAugust\tO\n26-29\tO\n.\tO\n\nThey\tO\nhave\tO\nbeen\tO\nasked\tO\nto\tO\nbring\tO\nwith\tO\nthem\tO\nthe\tO\nplacards\tO\nthey\tO\nwaved\tO\nwhen\tO\nClinton\tB-PER\naddressed\tO\nIreland\tB-LOC\nat\tO\na\tO\npacked\tO\nceremony\tO\nin\tO\nDublin\tB-LOC\ncity\tO\ncentre\tO\non\tO\nDecember\tO\n1\tO\n,\tO\nlast\tO\nyear\tO\n.\tO\n\nThey\tO\nread\tO\n:\tO\n\"\tO\nBallybunion\tB-ORG\nbacks\tO\nClinton\tB-PER\n.\tO\n\"\tO\n\n\"\tO\nThe\tO\nDemocratic\tB-MISC\nparty\tO\nhave\tO\nrequested\tO\nwe\tO\nbring\tO\nour\tO\nplacards\tO\nwith\tO\nus\tO\n.\tO\n\nWe\tO\nwill\tO\nbe\tO\nguests\tO\nof\tO\nthe\tO\nKennedys\tB-PER\n,\tO\n\"\tO\nsaid\tO\nFrank\tO\nQuilter\tO\n,\tO\none\tO\nof\tO\nthe\tO\ntwo\tO\nwho\tO\nhave\tO\nbeen\tO\ninvited\tO\nto\tO\nChicago\tB-LOC\n.\tO\n\nClinton\tB-PER\nmade\tO\na\tO\ntriumphant\tO\nIrish\tB-MISC\ntour\tO\nto\tO\nback\tO\na\tO\nNorthern\tB-LOC\nIreland\tI-LOC\npeace\tO\nprocess\tO\nbut\tO\nwas\tO\nforced\tO\nto\tO\ndrop\tO\nBallybunion\tB-ORG\nfrom\tO\na\tO\npacked\tO\nschedule\tO\nat\tO\nthe\tO\nlast\tO\nminute\tO\n.\tO\n\nBonn\tB-LOC\nsays\tO\nMoscow\tB-LOC\nhas\tO\npromised\tO\nto\tO\nobserve\tO\nceasefire\tO\n.\tO\n\nGermany\tB-LOC\nsaid\tO\non\tO\nThursday\tO\nit\tO\nhad\tO\nreceived\tO\nassurances\tO\nfrom\tO\nthe\tO\nRussian\tB-MISC\ngovernment\tO\nthat\tO\nits\tO\nforces\tO\nwould\tO\nobserve\tO\nthe\tO\nlatest\tO\nceasefire\tO\nin\tO\nChechnya\tB-LOC\n.\tO\n\nForeign\tB-ORG\nMinistry\tI-ORG\nspokesman\tO\nMartin\tB-PER\nErdmann\tI-PER\nsaid\tO\ntop\tO\nBonn\tB-LOC\ndiplomat\tO\nWolfgang\tB-PER\nIschinger\tI-PER\nhad\tO\nbeen\tO\nassured\tO\nby\tO\nsenior\tO\nRussian\tB-MISC\nofficials\tO\nthat\tO\nthe\tO\nultimatum\tO\nto\tO\nstorm\tO\nand\tO\ntake\tO\nthe\tO\nChechen\tB-MISC\ncapital\tO\nof\tO\nGrozny\tB-LOC\nwas\tO\nnot\tO\nvalid\tO\n.\tO\n\n\"\tO\nThe\tO\nRussian\tB-MISC\nside\tO\nconfirmed\tO\nthat\tO\nthe\tO\nceasefire\tO\nis\tO\nin\tO\nplace\tO\nand\tO\nthey\tO\nwill\tO\nkeep\tO\nto\tO\nit\tO\n,\tO\n\"\tO\nErdmann\tB-PER\ntold\tO\nReuters\tB-ORG\nafter\tO\nspeaking\tO\nby\tO\ntelephone\tO\nto\tO\nIschinger\tB-PER\n,\tO\nwho\tO\nhad\tO\nmet\tO\nthe\tO\nofficials\tO\non\tO\na\tO\ntwo-day\tO\nvisit\tO\nto\tO\nMoscow\tB-LOC\n.\tO\n\nHe\tO\nreturned\tO\nto\tO\nBonn\tB-LOC\non\tO\nThursday\tO\n.\tO\n\nIschinger\tB-PER\nis\tO\nthe\tO\npolitical\tO\ndirector\tO\nof\tO\nBonn\tB-LOC\n's\tO\nforeign\tO\nministry\tO\n.\tO\n\nIschinger\tB-PER\nsaid\tO\nhe\tO\nmet\tO\nthree\tO\nRussian\tB-MISC\ndeputy\tO\nforeign\tO\nministers\tO\nand\tO\na\tO\nvice\tO\ndefence\tO\nminister\tO\n,\tO\nwho\tO\nconfirmed\tO\nRussian\tB-MISC\nForeign\tO\nMinister\tO\nYevgeny\tB-PER\nPrimakov\tI-PER\n's\tO\npledge\tO\nthat\tO\nMoscow\tB-LOC\nwould\tO\nseek\tO\na\tO\npolitical\tO\nsolution\tO\nunder\tO\nthe\tO\naegis\tO\nof\tO\nthe\tO\nOrganisation\tB-ORG\nfor\tI-ORG\nSecurity\tI-ORG\nand\tI-ORG\nCooperation\tI-ORG\nin\tI-ORG\nEurope\tI-ORG\n(\tO\nOSCE\tB-ORG\n)\tO\n.\tO\n\n\"\tO\nThe\tO\nultimatum\tO\n(\tO\nto\tO\nstorm\tO\nGrozny\tB-LOC\n)\tO\nis\tO\nno\tO\nlonger\tO\nan\tO\nissue\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\nquoting\tO\nIschinger\tB-PER\n,\tO\nwho\tO\nhad\tO\nbeen\tO\nsent\tO\nto\tO\nMoscow\tB-LOC\nby\tO\nGerman\tB-MISC\nForeign\tO\nMinister\tO\nKlaus\tB-PER\nKinkel\tI-PER\nas\tO\nhis\tO\npersonal\tO\nenvoy\tO\nto\tO\nurge\tO\nan\tO\nend\tO\nto\tO\nMoscow\tB-LOC\n's\tO\nmilitary\tO\ncampaign\tO\nin\tO\nthe\tO\nbreakaway\tO\nregion\tO\n.\tO\n\nIschinger\tB-PER\nsaid\tO\nthe\tO\nthreat\tO\nof\tO\na\tO\nmajor\tO\nassault\tO\nto\tO\ntake\tO\nGrozny\tB-LOC\nhad\tO\nbeen\tO\nthe\tO\nunauthorised\tO\ninitiative\tO\nof\tO\nthe\tO\ncommanding\tO\ngeneral\tO\nand\tO\nnot\tO\nMoscow\tB-LOC\n's\tO\nintention\tO\n.\tO\n\nThe\tO\nofficials\tO\nhad\tO\nbeen\tO\npositive\tO\nabout\tO\nKinkel\tB-PER\n's\tO\nrequest\tO\non\tO\nWednesday\tO\nthat\tO\nPresident\tO\nBoris\tB-PER\nYeltsin\tI-PER\n's\tO\nsecurity\tO\nchief\tO\nAlexander\tB-PER\nLebed\tI-PER\nshould\tO\n,\tO\non\tO\nhis\tO\nreturn\tO\nto\tO\nMoscow\tB-LOC\n,\tO\nmeet\tO\nTim\tB-PER\nGoldiman\tI-PER\n,\tO\nthe\tO\nOSCE\tB-ORG\nrepresentative\tO\nresponsible\tO\nfor\tO\nChechnya\tB-LOC\n,\tO\nhe\tO\nsaid\tO\n.\tO\n\nIndia\tB-LOC\nsays\tO\nsees\tO\nno\tO\narms\tO\nrace\tO\nwith\tO\nChina\tB-LOC\n,\tO\nPakistan\tB-LOC\n.\tO\n\nIndia\tB-LOC\nsaid\tO\non\tO\nThursday\tO\nthat\tO\nits\tO\nopposition\tO\nto\tO\na\tO\nglobal\tO\nnuclear\tO\ntest\tO\nban\tO\ntreaty\tO\ndid\tO\nnot\tO\nmean\tO\nNew\tB-LOC\nDelhi\tI-LOC\nintended\tO\nto\tO\nenter\tO\ninto\tO\nan\tO\narms\tO\nrace\tO\nwith\tO\nneighbouring\tO\nPakistan\tB-LOC\nand\tO\nChina\tB-LOC\n.\tO\n\nForeign\tO\nMinister\tO\nI.K.\tB-PER\nGujral\tI-PER\nwas\tO\nasked\tO\nat\tO\na\tO\nnews\tO\nconference\tO\nif\tO\nIndia\tB-LOC\n's\tO\ndecision\tO\nto\tO\nblock\tO\nadoption\tO\nof\tO\nthe\tO\naccord\tO\nin\tO\nGeneva\tB-LOC\nwould\tO\nlead\tO\nto\tO\nan\tO\narms\tO\nrace\tO\nwith\tO\nPakistan\tB-LOC\nand\tO\nChina\tB-LOC\n.\tO\n\n\"\tO\nI\tO\ndo\tO\nn't\tO\nsee\tO\nthat\tO\npossibility\tO\nbecause\tO\nIndia\tB-LOC\nis\tO\nnot\tO\nentering\tO\ninto\tO\nany\tO\narms\tO\nrace\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\"\tO\n\nChina\tB-LOC\n,\tO\nalong\tO\nwith\tO\nBritain\tB-LOC\n,\tO\nFrance\tB-LOC\n,\tO\nRussia\tB-LOC\nand\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\n,\tO\nis\tO\na\tO\ndeclared\tO\nnuclear\tO\npower\tO\n.\tO\n\nIndia\tB-LOC\ncarried\tO\nout\tO\na\tO\nnuclear\tO\ntest\tO\nin\tO\n1974\tO\nbut\tO\nsays\tO\nit\tO\nhas\tO\nnot\tO\nbuilt\tO\nthe\tO\nbomb\tO\n.\tO\n\nExperts\tO\nbelieve\tO\nboth\tO\nIndia\tB-LOC\nand\tO\nPakistan\tB-LOC\ncould\tO\nquickly\tO\nassemble\tO\nnuclear\tO\nweapons\tO\n.\tO\n\nGujral\tB-PER\nsaid\tO\nhe\tO\ndid\tO\nnot\tO\nexpect\tO\nIndia\tB-LOC\n's\tO\nveto\tO\nof\tO\nthe\tO\nComprehensive\tB-MISC\nTest\tI-MISC\nBan\tI-MISC\nTreaty\tI-MISC\n(\tO\nCTBT\tB-MISC\n)\tO\nto\tO\ndamage\tO\nbilateral\tO\nties\tO\nwith\tO\nother\tO\nnations\tO\n.\tO\n\nGujral\tB-PER\nsaid\tO\nIndia\tB-LOC\nwould\tO\nre-examine\tO\nits\tO\nposition\tO\nif\tO\nthe\tO\ntreaty\tO\n,\tO\nparticularly\tO\na\tO\nclause\tO\nproviding\tO\nfor\tO\nits\tO\nentry\tO\ninto\tO\nforce\tO\n,\tO\nwas\tO\nmodified\tO\n.\tO\n\nAsked\tO\nwhat\tO\nIndia\tB-LOC\nwould\tO\ndo\tO\nif\tO\nthe\tO\npact\tO\nwere\tO\nforwarded\tO\nto\tO\nthe\tO\nUnited\tB-ORG\nNations\tI-ORG\nGeneral\tI-ORG\nAssembly\tI-ORG\n,\tO\nGujral\tB-PER\nsaid\tO\n:\tO\n\"\tO\nThat\tO\nbridge\tO\nI\tO\nwill\tO\ncross\tO\nwhen\tO\nI\tO\ncome\tO\nto\tO\nit\tO\n.\tO\n\"\tO\n\nIn\tO\na\tO\nwritten\tO\nstatement\tO\nreleased\tO\nat\tO\nthe\tO\nnews\tO\nconference\tO\n,\tO\nGujral\tB-PER\nreiterated\tO\nIndia\tB-LOC\n's\tO\nobjections\tO\nto\tO\nthe\tO\ntreaty\tO\n,\tO\nunder\tO\nnegotiation\tO\nat\tO\nthe\tO\nConference\tB-MISC\non\tI-MISC\nDisarmament\tI-MISC\nin\tO\nGeneva\tB-LOC\n.\tO\n\nGujral\tB-PER\nsaid\tO\nIndia\tB-LOC\nhad\tO\nnational\tO\nsecurity\tO\nconcerns\tO\nthat\tO\nmade\tO\nit\tO\nimpossible\tO\nfor\tO\nNew\tB-LOC\nDelhi\tI-LOC\nto\tO\nsign\tO\nthe\tO\nCTBT\tB-MISC\n.\tO\n\n\"\tO\nOur\tO\nsecurity\tO\nconcerns\tO\noblige\tO\nus\tO\nto\tO\nmaintain\tO\nour\tO\nnuclear\tO\noption\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n,\tO\nadding\tO\nthat\tO\nIndia\tB-LOC\nhad\tO\nexercised\tO\nrestraint\tO\nin\tO\nnot\tO\ncarrying\tO\nout\tO\nany\tO\nnuclear\tO\ntests\tO\nsince\tO\nthe\tO\ncountry\tO\n's\tO\nlone\tO\ntest\tO\nblast\tO\nin\tO\n1974\tO\n.\tO\n\nBritain\tB-LOC\nsays\tO\ndeath\tO\nof\tO\nits\tO\ncitizen\tO\nwill\tO\nsour\tO\nties\tO\n.\tO\n\nA\tO\nBritish\tB-MISC\nminister\tO\nexpressed\tO\nhis\tO\ngovernment\tO\n's\tO\nofficial\tO\ndisquiet\tO\non\tO\nThursday\tO\nat\tO\nthe\tO\nrecent\tO\ndeath\tO\nof\tO\na\tO\nBritish\tB-MISC\ncitizen\tO\nof\tO\nBangladeshi\tB-MISC\norigin\tO\nat\tO\nDhaka\tB-LOC\nairport\tO\n.\tO\n\n\"\tO\nI\tO\nhave\tO\ntold\tO\nBangladesh\tB-LOC\nleaders\tO\nthat\tO\nBritish\tB-MISC\ngoverment\tO\nhas\tO\nattached\tO\nserious\tO\nimportance\tO\nto\tO\nthe\tO\nresolution\tO\nof\tO\nthe\tO\ntragic\tO\ndeath\tO\nof\tO\nSiraj\tB-PER\nMia\tI-PER\n,\tO\n\"\tO\nUnder-Secretary\tO\nof\tO\nState\tO\nfor\tO\nForeign\tO\nand\tO\nCommonwealth\tB-ORG\nAffairs\tO\nLiam\tB-PER\nFox\tI-PER\nFox\tI-PER\n,\tO\ntold\tO\nreporters\tO\n.\tO\n\nSiraj\tB-PER\nMia\tI-PER\ndied\tO\nat\tO\nDhaka\tB-LOC\nairport\tO\non\tO\nMay\tO\n9\tO\nduring\tO\ninterogation\tO\nby\tO\ncustoms\tO\nofficials\tO\nafter\tO\narriving\tO\nfrom\tO\nLondon\tB-LOC\n.\tO\n\nFox\tB-PER\n,\tO\nwho\tO\narrived\tO\nin\tO\nBangladesh\tB-LOC\non\tO\nTuesday\tO\non\tO\nfour-day\tO\nvisit\tO\n,\tO\nsaid\tO\nBritain\tB-LOC\nwanted\tO\nDhaka\tB-LOC\nto\tO\nact\tO\nseriously\tO\non\tO\nthe\tO\ncase\tO\n.\tO\n\nthis\tO\nis\tO\nan\tO\nimportant\tO\nissue\tO\nin\tO\nour\tO\nrelationship\tO\n\"\tO\n,\tO\nsaid\tO\nFox\tB-PER\n,\tO\nwho\tO\nis\tO\ndue\tO\nto\tO\nleave\tO\nfor\tO\nNepal\tB-LOC\non\tO\nFriday\tO\n.\tO\n\nHe\tO\nsaid\tO\nthe\tO\nMia\tB-PER\n's\tO\nissue\tO\nhad\tO\nbeen\tO\nraised\tO\nin\tO\nthe\tO\nHouse\tB-ORG\nof\tI-ORG\nCommons\tI-ORG\n.\tO\n\nFox\tB-PER\nsaid\tO\nhe\tO\nhad\tO\nbrought\tO\nup\tO\nthe\tO\nissue\tO\nat\tO\nevery\tO\nmeeting\tO\nhe\tO\nhad\tO\nhad\tO\nwith\tO\ngovernment\tO\nleaders\tO\nin\tO\nDhaka\tB-LOC\n.\tO\n\nHe\tO\nsaid\tO\nthe\tO\nBangladesh\tB-LOC\ngovernment\tO\nhad\tO\nassured\tO\nhim\tO\nit\tO\nwas\tO\ntaking\tO\nthe\tO\nmatter\tO\nseriously\tO\n.\tO\n\n\"\tO\nThe\tO\nBritish\tB-MISC\ngovernment\tO\nwants\tO\na\tO\nthorough\tO\ninvestigation\tO\nand\tO\na\tO\njust\tO\noutcome\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\nFox\tB-PER\nsaid\tO\nthe\tO\nBritish\tB-MISC\ngovernment\tO\nwanted\tO\nan\tO\nend\tO\nto\tO\nthe\tO\nalleged\tO\nharassment\tO\nof\tO\nits\tO\nnationals\tO\nat\tO\nDhaka\tB-LOC\nairport\tO\nby\tO\ncustoms\tO\nofficials\tO\n.\tO\n\nBangladesh\tB-LOC\n's\tO\nCriminal\tB-ORG\nInvestigation\tI-ORG\nDepartment\tI-ORG\nhas\tO\ncharged\tO\ntwo\tO\nimmigration\tO\nofficials\tO\nin\tO\nconnection\tO\nwith\tO\nMia\tB-PER\n's\tO\nkilling\tO\n.\tO\n\nMia\tB-PER\n,\tO\na\tO\nfather\tO\nof\tO\nfive\tO\nchildren\tO\n,\tO\nhad\tO\na\tO\nrestaurant\tO\nbusiness\tO\nin\tO\na\tO\nLondon\tB-LOC\nsuburb\tO\n.\tO\n\nIndia\tB-LOC\nfears\tO\nattempts\tO\nto\tO\ndisrupt\tO\nKashmir\tB-LOC\npolls\tO\n.\tO\n\nSRINAGAR\tB-LOC\n,\tO\nIndia\tO\n1996-08-22\tO\n\nIndia\tB-LOC\n's\tO\nHome\tO\n(\tO\ninterior\tO\n)\tO\nMinister\tO\naccused\tO\nPakistan\tB-LOC\non\tO\non\tO\nThursday\tO\nof\tO\nplanning\tO\nto\tO\ndisrupt\tO\nstate\tO\nelections\tO\nin\tO\ntroubled\tO\nJammu\tB-LOC\nand\tO\nKashmir\tB-LOC\nstate\tO\n.\tO\n\n\"\tO\nIt\tO\nseems\tO\nthat\tO\nfrom\tO\nacross\tO\nthe\tO\nborder\tO\nthere\tO\nis\tO\ngoing\tO\nto\tO\nbe\tO\na\tO\nplanned\tO\nattempt\tO\nto\tO\ndisrupt\tO\nthe\tO\nelections\tO\n,\tO\n\"\tO\nInderjit\tB-PER\nGupta\tI-PER\ntold\tO\nreporters\tO\nin\tO\nthe\tO\nstate\tO\ncapital\tO\nSrinagar\tB-LOC\n.\tO\n\nThe\tO\nlocal\tO\npolls\tO\nnext\tO\nmonth\tO\nwill\tO\nbe\tO\nthe\tO\nfirst\tO\nsince\tO\n1987\tO\nin\tO\nthe\tO\nstate\tO\n,\tO\nclamped\tO\nunder\tO\ndirect\tO\nrule\tO\nfrom\tO\nNew\tB-LOC\nDelhi\tI-LOC\nsince\tO\n1990\tO\n.\tO\n\nIndia\tB-LOC\nhas\tO\noften\tO\naccused\tO\nPakistan\tB-LOC\nof\tO\nabetting\tO\nmilitancy\tO\nin\tO\nthe\tO\nvalley\tO\n,\tO\na\tO\ncharge\tO\nIslamabad\tB-LOC\nhas\tO\nalways\tO\ndenied\tO\n.\tO\n\nGupta\tB-PER\nsaid\tO\nthere\tO\nmight\tO\nbe\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\npeople\tO\ninfiltrating\tO\nthe\tO\nKashmir\tB-LOC\nvalley\tO\nto\tO\ncreate\tO\ndisturbance\tO\nin\tO\nthe\tO\nregion\tO\n.\tO\n\n\"\tO\nWe\tO\nnoticed\tO\namong\tO\nthe\tO\npeople\tO\nwho\tO\ncome\tO\nfrom\tO\nacross\tO\nthe\tO\nborder\tO\n,\tO\nthere\tO\nis\tO\na\tO\ngrowing\tO\nnumber\tO\nof\tO\nforeign\tO\nmercenaries\tO\n,\tO\n\"\tO\nGupta\tB-PER\nsaid\tO\n.\tO\n\nIndia\tB-LOC\nand\tO\nPakistan\tB-LOC\nhave\tO\nfought\tO\ntwo\tO\nof\tO\ntheir\tO\nthree\tO\nwars\tO\nover\tO\nthe\tO\ntroubled\tO\nregion\tO\nof\tO\nKashmir\tB-LOC\nsince\tO\nindependence\tO\nfrom\tO\nBritain\tB-LOC\nin\tO\n1947\tO\n.\tO\n\nPrime\tO\nMinister\tO\nH.D.\tB-PER\nDeve\tI-PER\nGowda\tI-PER\n's\tO\ncentre-left\tO\ngovernment\tO\nhopes\tO\nthe\tO\nelections\tO\nwill\tO\nhelp\tO\nrestore\tO\nnormality\tO\nand\tO\ndemocratic\tO\nrule\tO\nin\tO\nJammu\tB-LOC\nand\tO\nKashmir\tB-LOC\n,\tO\nwhere\tO\nmore\tO\nthan\tO\n20,000\tO\npeople\tO\nhave\tO\ndied\tO\nin\tO\ninsurgency-related\tO\nviolence\tO\nsince\tO\n1990\tO\n.\tO\n\nOver\tO\na\tO\ndozen\tO\nmilitant\tO\ngroups\tO\nare\tO\nfighting\tO\nNew\tB-LOC\nDelhi\tI-LOC\n's\tO\nrule\tO\nin\tO\nthe\tO\nstate\tO\n.\tO\n\nDhaka\tB-LOC\nstocks\tO\nend\tO\nup\tO\non\tO\ngains\tO\nby\tO\nengineering\tO\n,\tO\nbanks\tO\n.\tO\n\nDhaka\tB-LOC\nstocks\tO\nedged\tO\nup\tO\non\tO\nsharply\tO\nhigher\tO\nvolume\tO\nas\tO\nengineering\tO\nand\tO\ncash\tO\nshares\tO\ngained\tO\namid\tO\nbuying\tO\nby\tO\nboth\tO\nsmall\tO\nand\tO\ninstitutional\tO\ninvestors\tO\n,\tO\nbrokers\tO\nsaid\tO\n.\tO\n\nThe\tO\nDhaka\tB-ORG\nStock\tI-ORG\nExchange\tI-ORG\n(\tO\nDSE\tB-ORG\n)\tO\nall-share\tO\nprice\tO\nindex\tO\nrose\tO\n8.05\tO\npoints\tO\nor\tO\n0.7\tO\npercent\tO\nto\tO\n1,156.79\tO\non\tO\na\tO\nturnover\tO\nof\tO\n146.2\tO\nmillion\tO\ntaka\tO\n.\tO\n\nNational\tB-ORG\nBank\tI-ORG\nrose\tO\n12.71\tO\ntaka\tO\nto\tO\n228.7\tO\n,\tO\nEastern\tB-ORG\nCables\tI-ORG\ngained\tO\n20.37\tO\nto\tO\n677.98\tO\nand\tO\nApex\tB-ORG\nTannery\tI-ORG\nlost\tO\n22.72\tO\nto\tO\n597\tO\n.\tO\n\nIndia\tB-LOC\nRBI\tB-ORG\nchief\tO\nsees\tO\ncut\tO\nin\tO\ncash\tO\nreserve\tO\nratio\tO\n.\tO\n\nThe\tO\nReserve\tB-ORG\nbank\tI-ORG\nof\tI-ORG\nIndia\tI-ORG\ngovernor\tO\nC.\tB-PER\nRangarajan\tI-PER\nsaid\tO\non\tO\nThursday\tO\nthat\tO\nhe\tO\nexpected\tO\nthe\tO\ncash\tO\nreserve\tO\nratio\tO\n(\tO\nCRR\tO\n)\tO\nmaintained\tO\nby\tO\nbanks\tO\nto\tO\nbe\tO\nreduced\tO\nover\tO\nthe\tO\nmedium\tO\nterm\tO\n.\tO\n\n\"\tO\nOver\tO\nthe\tO\nmedium\tO\nterm\tO\n,\tO\nyes\tO\n,\tO\n\"\tO\nhe\tO\ntold\tO\nReuters\tB-ORG\nafter\tO\naddressing\tO\nindustrialists\tO\nin\tO\nthe\tO\ncapital\tO\n.\tO\n\nRangarajan\tB-PER\nexplained\tO\nthat\tO\nthe\tO\ncash\tO\nreserve\tO\nratio\tO\nwas\tO\nan\tO\ninstrument\tO\nthat\tO\ncentral\tO\nbanks\tO\ncould\tO\nuse\tO\nto\tO\nregulate\tO\nmoney\tO\nsupply\tO\nby\tO\nreducing\tO\nor\tO\nincreasing\tO\nthe\tO\nratio\tO\n.\tO\n\n--\tO\nNew\tB-LOC\nDelhi\tI-LOC\nnewsroom\tO\n,\tO\n+91-11-3012024\tO\n\nTwo\tO\npct\tO\nIndia\tB-LOC\ncurrent\tO\naccount\tO\ndeficit\tO\nviable\tO\n-\tO\nRBI\tB-ORG\n.\tO\n\nThe\tO\nReserve\tB-ORG\nBank\tI-ORG\nof\tI-ORG\nIndia\tI-ORG\nGovernor\tO\nChakravarty\tB-PER\nRangarajan\tI-PER\nsaid\tO\non\tO\nThursday\tO\nthat\tO\na\tO\ncurrent\tO\naccount\tO\ndeficit\tO\nof\tO\ntwo\tO\npercent\tO\nof\tO\ngross\tO\ndomestic\tO\nproduct\tO\n(\tO\nGDP\tO\n)\tO\nwas\tO\nsustainable\tO\ngiven\tO\nthe\tO\ncurrrent\tO\nrate\tO\nof\tO\ngrowth\tO\n.\tO\n\n\"\tO\nThe\tO\ncurrent\tO\naccount\tO\ndeficit\tO\nof\tO\naround\tO\ntwo\tO\npercent\tO\nof\tO\nGDP\tO\nis\tO\na\tO\nsustainable\tO\nlevel\tO\nof\tO\ndeficit\tO\ngiven\tO\nthe\tO\nexpected\tO\nreal\tO\ngrowth\tO\nrate\tO\nand\tO\nthe\tO\ntrends\tO\nin\tO\nimports\tO\nand\tO\nexports\tO\n,\tO\n\"\tO\nRangarajan\tB-PER\nsaid\tO\nin\tO\nan\tO\naddress\tO\nto\tO\nbusiness\tO\nleaders\tO\nin\tO\nNew\tB-LOC\nDelhi\tI-LOC\n.\tO\n\nRangarajan\tB-PER\nsaid\tO\na\tO\ncurrent\tO\naccount\tO\ndeficit\tO\nof\tO\ntwo\tO\npercent\tO\nbrought\tO\nabout\tO\nby\tO\na\tO\n16-17\tO\npercent\tO\nannual\tO\ngrowth\tO\nin\tO\nexports\tO\nand\tO\na\tO\n14-15\tO\npercent\tO\nrise\tO\nin\tO\nimports\tO\nalong\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nnon-debt\tO\nflows\tO\ncould\tO\nlead\tO\nto\tO\na\tO\nreduction\tO\nin\tO\nthe\tO\ndebt-service\tO\nratio\tO\nto\tO\nbelow\tO\n20\tO\npercent\tO\nover\tO\nthe\tO\nnext\tO\nfive\tO\nyears\tO\n.\tO\n\n--\tO\nBombay\tB-LOC\nnewsroom\tO\n+91-22-265\tO\n9000\tO\n\nMother\tB-PER\nTeresa\tI-PER\ndevoted\tO\nto\tO\nworld\tO\n's\tO\npoor\tO\n.\tO\n\nMother\tB-PER\nTeresa\tI-PER\n,\tO\nknown\tO\nas\tO\nthe\tO\nSaint\tB-PER\nof\tI-PER\nthe\tI-PER\nGutters\tI-PER\n,\tO\nwon\tO\nthe\tO\nNobel\tB-MISC\nPeace\tI-MISC\nPrize\tI-MISC\nin\tO\n1979\tO\nfor\tO\nbringing\tO\nhope\tO\nand\tO\ndignity\tO\nto\tO\nmillions\tO\nof\tO\npoor\tO\n,\tO\nunwanted\tO\npeople\tO\nwith\tO\nher\tO\nsimple\tO\nmessage\tO\n:\tO\n\"\tO\nThe\tO\npoor\tO\nmust\tO\nknow\tO\nthat\tO\nwe\tO\nlove\tO\nthem\tO\n.\tO\n\"\tO\n\nWhile\tO\nthe\tO\nworld\tO\nheaps\tO\nhonours\tO\non\tO\nher\tO\nand\tO\neven\tO\nregards\tO\nher\tO\nas\tO\na\tO\nliving\tO\nsaint\tO\n,\tO\nthe\tO\nnun\tO\nof\tO\nAlbanian\tB-MISC\ndescent\tO\nmaintains\tO\nshe\tO\nis\tO\nmerely\tO\ndoing\tO\nGod\tB-PER\n's\tO\nwork\tO\n.\tO\n\nThe\tO\ndiminutive\tO\nRoman\tB-MISC\nCatholic\tI-MISC\nmissionary\tO\nwas\tO\non\tO\nrespiratory\tO\nsupport\tO\nin\tO\nintensive\tO\ncare\tO\nin\tO\nan\tO\nIndian\tB-MISC\nnursing\tO\nhome\tO\non\tO\nThursday\tO\nafter\tO\nsuffering\tO\nheart\tO\nfailure\tO\n.\tO\n\nBut\tO\nan\tO\nattending\tO\ndoctor\tO\nsaid\tO\nMother\tB-PER\nTeresa\tI-PER\n,\tO\nwho\tO\nturns\tO\n86\tO\nnext\tO\nTuesday\tO\n,\tO\nwas\tO\nconscious\tO\nand\tO\nin\tO\nstable\tO\ncondition\tO\n.\tO\n\nThe\tO\ntask\tO\nMother\tB-PER\nTeresa\tI-PER\nbegan\tO\nalone\tO\nin\tO\n1949\tO\nin\tO\nthe\tO\nslums\tO\nof\tO\ndensely-populated\tO\nCalcutta\tB-LOC\n,\tO\nand\tO\ngrew\tO\nto\tO\ntouch\tO\nthe\tO\nhearts\tO\nof\tO\npeople\tO\naround\tO\nthe\tO\nworld\tO\n.\tO\n\nWhen\tO\nin\tO\n1979\tO\nshe\tO\nwas\tO\ntold\tO\nshe\tO\nhad\tO\nwon\tO\nthe\tO\nNobel\tB-MISC\nPeace\tI-MISC\nPrize\tI-MISC\n,\tO\nshe\tO\nsaid\tO\ncharacteristically\tO\n:\tO\n\"\tO\nI\tO\nam\tO\nunworthy\tO\n.\tO\n\"\tO\n\nThe\tO\nworld\tO\ndisagreed\tO\n,\tO\nshowering\tO\nmore\tO\nthan\tO\n80\tO\nnational\tO\nand\tO\ninternational\tO\nhonours\tO\non\tO\nher\tO\nincluding\tO\nthe\tO\nBharat\tB-MISC\nRatna\tI-MISC\n,\tO\nor\tO\nJewel\tB-MISC\nof\tI-MISC\nIndia\tI-MISC\n,\tO\nthe\tO\ncountry\tO\n's\tO\nhighest\tO\ncivilian\tO\naward\tO\n.\tO\n\nA\tO\nyear\tO\nlater\tO\n,\tO\nthe\tO\nVatican\tB-LOC\nannounced\tO\nshe\tO\nwas\tO\nstepping\tO\ndown\tO\nas\tO\nSuperior\tO\nof\tO\nher\tO\nMissionaries\tB-ORG\nof\tI-ORG\nCharity\tI-ORG\norder\tO\n.\tO\n\nIn\tO\n1991\tO\n,\tO\nMother\tB-PER\nTeresa\tI-PER\nwas\tO\ntreated\tO\nat\tO\na\tO\nCalifornia\tB-LOC\nhospital\tO\nfor\tO\nheart\tO\ndisease\tO\nand\tO\nbacterial\tO\npneumonia\tO\n.\tO\n\nIn\tO\n1993\tO\n,\tO\nshe\tO\nfell\tO\nin\tO\nRome\tB-LOC\nand\tO\nbroke\tO\nthree\tO\nribs\tO\n.\tO\n\nIn\tO\nAugust\tO\nthe\tO\nsame\tO\nyear\tO\n,\tO\nwhile\tO\nin\tO\nNew\tB-LOC\nDelhi\tI-LOC\nto\tO\nreceive\tO\nyet\tO\nanother\tO\naward\tO\n,\tO\nshe\tO\ndeveloped\tO\nmalaria\tO\n,\tO\ncomplicated\tO\nby\tO\nher\tO\nheart\tO\nand\tO\nlung\tO\nproblems\tO\n.\tO\n\nMother\tB-PER\nTeresa\tI-PER\nwas\tO\nborn\tO\nAgnes\tB-PER\nGoinxha\tI-PER\nBejaxhiu\tI-PER\nto\tO\nAlbanian\tB-MISC\nparents\tO\nin\tO\nSkopje\tB-LOC\n,\tO\nin\tO\nwhat\tO\nwas\tO\nthen\tO\nSerbia\tB-LOC\n,\tO\non\tO\nAugust\tO\n27\tO\n,\tO\n1910\tO\n.\tO\n\nAt\tO\nthe\tO\nage\tO\nof\tO\n18\tO\nshe\tO\nbecame\tO\na\tO\nLoretto\tB-MISC\nnun\tO\n,\tO\nhoping\tO\nto\tO\nwork\tO\nat\tO\nthe\tO\nOrder\tO\n's\tO\nCalcutta\tB-LOC\nmission\tO\n.\tO\n\nShe\tO\nwas\tO\nsent\tO\nto\tO\nLoretto\tB-LOC\nAbbey\tI-LOC\nin\tO\nDublin\tB-LOC\nand\tO\nfrom\tO\nthere\tO\nto\tO\nIndia\tB-LOC\nto\tO\nbegin\tO\nher\tO\nnovitiate\tO\nand\tO\nteach\tO\ngeography\tO\nat\tO\na\tO\nconvent\tO\nschool\tO\nin\tO\nCalcutta\tB-LOC\n.\tO\n\nThe\tO\nVatican\tB-LOC\nand\tO\nthe\tO\nmother\tO\nsuperior\tO\nin\tO\nDublin\tB-LOC\napproved\tO\nand\tO\nafter\tO\nintensive\tO\ntraining\tO\nas\tO\na\tO\nnurse\tO\nwith\tO\nAmerican\tB-MISC\nmissionaries\tO\nshe\tO\nopened\tO\nher\tO\nfirst\tO\nCalcutta\tB-LOC\nslum\tO\nschool\tO\nin\tO\nDecember\tO\n1949\tO\n.\tO\n\nShe\tO\ntook\tO\nthe\tO\nname\tO\nof\tO\nTeresa\tB-PER\n,\tO\nafter\tO\nFrance\tB-LOC\n's\tO\nSaint\tO\nTherese\tB-PER\nof\tO\nthe\tO\nChild\tO\nJesus\tB-PER\n.\tO\n\nIn\tO\nIndia\tB-LOC\nshe\tO\nwas\tO\nsimply\tO\ncalled\tO\nMother\tB-PER\n.\tO\n\nMother\tB-PER\nTeresa\tI-PER\nset\tO\nup\tO\nher\tO\nfirst\tO\nhome\tO\nfor\tO\nthe\tO\ndying\tO\nin\tO\na\tO\nHindu\tB-MISC\nrest\tO\nhouse\tO\nin\tO\nCalcutta\tB-LOC\nafter\tO\nshe\tO\nsaw\tO\na\tO\npenniless\tO\nwoman\tO\nturned\tO\naway\tO\nby\tO\na\tO\ncity\tO\nhospital\tO\n.\tO\n\nNamed\tO\n\"\tO\nNirmal\tB-LOC\nHriday\tI-LOC\n\"\tO\n(\tO\nTender\tB-LOC\nHeart\tI-LOC\n)\tO\n,\tO\nit\tO\nwas\tO\nthe\tO\nfirst\tO\nof\tO\na\tO\nchain\tO\nof\tO\n150\tO\nhomes\tO\nfor\tO\ndying\tO\n,\tO\ndestitute\tO\npeople\tO\n,\tO\nadmitting\tO\nnearly\tO\n18,000\tO\na\tO\nyear\tO\n.\tO\n\nHer\tO\nMissionaries\tB-ORG\nof\tI-ORG\nCharity\tI-ORG\n,\tO\na\tO\nRoman\tB-MISC\nCatholic\tI-MISC\nreligious\tO\norder\tO\nshe\tO\nfounded\tO\nin\tO\n1949\tO\n,\tO\nnow\tO\nruns\tO\nabout\tO\n300\tO\nhomes\tO\nfor\tO\nunwanted\tO\nchildren\tO\nand\tO\nthe\tO\ndestitute\tO\nin\tO\nIndia\tB-LOC\nand\tO\nabroad\tO\n.\tO\n\nIn\tO\n1994\tO\na\tO\nBritish\tB-MISC\ntelevision\tO\ndocumentary\tO\ncalled\tO\nthe\tO\nmyth\tO\naround\tO\nMother\tB-PER\nTeresa\tI-PER\na\tO\nmixture\tO\nof\tO\n\"\tO\nhyperbole\tO\nand\tO\ncredulity\tO\n\"\tO\n.\tO\n\nCatholics\tB-MISC\naround\tO\nthe\tO\nworld\tO\nrose\tO\nto\tO\nher\tO\ndefence\tO\n.\tO\n\nRTRS\tB-ORG\n-\tO\nFOCUS-News\tO\nforecasts\tO\nalien-led\tO\nprofit\tO\nboost\tO\n.\tO\n\nMedia\tO\nbaron\tO\nRupert\tB-PER\nMurdoch\tI-PER\n's\tO\nNews\tB-ORG\nCorp\tI-ORG\nLtd\tI-ORG\nreported\tO\nlower\tO\nthan\tO\nexpected\tO\n1995/96\tO\nprofits\tO\non\tO\nThursday\tO\n,\tO\nbut\tO\nforecast\tO\nthat\tO\nthe\tO\nhit\tO\nfilm\tO\n\"\tO\nIndependence\tB-MISC\nDay\tI-MISC\n\"\tO\nwould\tO\nhelp\tO\nincrease\tO\nprofits\tO\nby\tO\nat\tO\nleast\tO\n20\tO\npercent\tO\nin\tO\n1996/97\tO\n.\tO\n\n\"\tO\nFrom\tO\nan\tO\nearnings\tO\nperspective\tO\n,\tO\nthe\tO\ncurrent\tO\nfiscal\tO\nyear\tO\nhas\tO\nbegun\tO\nwith\tO\ngreat\tO\npromise\tO\ndue\tO\nto\tO\nthe\tO\nhit\tO\nmotion\tO\npicture\tO\n'\tO\nIndependence\tB-MISC\nDay\tI-MISC\n,\tO\n'\tO\n\"\tO\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tO\nin\tO\na\tO\nstatement\tO\nannouncing\tO\nits\tO\nresults\tO\nfor\tO\nthe\tO\nyear\tO\nto\tO\nJune\tO\n30\tO\n,\tO\n1996\tO\n.\tO\n\nIt\tO\nsaid\tO\nmoderating\tO\npaper\tO\nprices\tO\nand\tO\nsolid\tO\norders\tO\nfor\tO\nadvertising\tO\nat\tO\nits\tO\nFox\tB-ORG\nBroadcasting\tI-ORG\ntelevision\tO\nnetwork\tO\nin\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\nwould\tO\nalso\tO\nhelp\tO\nboost\tO\nprofits\tO\nin\tO\nthe\tO\n1996/97\tO\nyear\tO\n.\tO\n\"\tO\n\nA\tO\nbudgeted\tO\nprofit\tO\nincrease\tO\nof\tO\nat\tO\nleast\tO\n20\tO\npercent\tO\nfor\tO\nthe\tO\nfull\tO\nyear\tO\ncurrently\tO\nappears\tO\nvery\tO\nattainable\tO\n,\tO\n\"\tO\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tO\n.\tO\n\nNews\tB-ORG\nannounced\tO\npre-abnormals\tO\nnet\tO\nprofit\tO\nfor\tO\nthe\tO\nyear\tO\nfell\tO\nsix\tO\npercent\tO\nto\tO\nA$\tB-MISC\n1.26\tO\nbillion\tO\n(\tO\nUS$\tB-MISC\n995\tO\nmillion\tO\n)\tO\nand\tO\nearnings\tO\nper\tO\nshare\tO\ndropped\tO\nto\tO\n40\tO\ncents\tO\nfrom\tO\n46\tO\ncents\tO\n.\tO\n\nAnalysts\tO\nhad\tO\non\tO\naverage\tO\nexpected\tO\na\tO\npre-abnormals\tO\nprofit\tO\nof\tO\nA$\tB-MISC\n1.343\tO\nbillion\tO\n.\tO\n\n\"\tO\nThe\tO\nyear\tO\njust\tO\ngone\tO\nwas\tO\ndisappointing\tO\n,\tO\nbut\tO\nthe\tO\noutlook\tO\nfor\tO\nthe\tO\ncurrent\tO\nyear\tO\nlooks\tO\ngood\tO\n,\tO\n\"\tO\nFirst\tB-ORG\nPacific\tI-ORG\nmedia\tO\nanalyst\tO\nLachlan\tB-PER\nDrummond\tI-PER\nsaid\tO\n.\tO\n\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tO\nstrong\tO\nperformances\tO\nin\tO\nU.S.\tB-LOC\ntelevision\tO\nand\tO\nBritish\tB-MISC\nnewspapers\tO\nwere\tO\noffset\tO\nby\tO\nlower\tO\nprofits\tO\nfrom\tO\nNews\tB-ORG\nCorp\tI-ORG\n's\tO\nmagazine\tO\nand\tO\npublishing\tO\ndivisions\tO\nand\tO\nfurther\tO\nhefty\tO\nlosses\tO\nfrom\tO\nits\tO\nAsian\tB-ORG\nStar\tI-ORG\nTV\tI-ORG\noperations\tO\n.\tO\n\nThroughout\tO\nthe\tO\ngroup\tO\n,\tO\nhigher\tO\npaper\tO\nprices\tO\nincreased\tO\ncosts\tO\nby\tO\nover\tO\nUS$\tB-MISC\n300\tO\nmillion\tO\n,\tO\n\"\tO\nit\tO\nsaid\tO\n.\tO\n\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tO\nBritish\tB-MISC\nnewspaper\tO\noperating\tO\nprofits\tO\nrose\tO\n10\tO\npercent\tO\nfor\tO\nthe\tO\nyear\tO\n,\tO\nas\tO\nhigher\tO\ncover\tO\nprices\tO\nat\tO\nThe\tB-ORG\nSun\tI-ORG\nand\tO\nThe\tB-ORG\nTimes\tI-ORG\nand\tO\nhigher\tO\nadvertising\tO\nvolumes\tO\noffset\tO\nincreased\tO\nnewsprint\tO\ncosts\tO\n.\tO\n\nAdvertising\tO\nrevenues\tO\nat\tO\nThe\tB-ORG\nTimes\tI-ORG\ngrew\tO\n20\tO\npercent\tO\n.\tO\n\nAnalysts\tO\nsaid\tO\nsharply\tO\nlower\tO\nearnings\tO\nfrom\tO\nNews\tB-ORG\nCorp\tI-ORG\n's\tO\nbook\tO\npublishing\tO\ndivision\tO\nand\tO\nits\tO\nU.S.\tB-LOC\nmagazines\tO\nhad\tO\nbeen\tO\nthe\tO\nmajor\tO\nsurprises\tO\nin\tO\nthe\tO\nresults\tO\nfor\tO\n1995/96\tO\n.\tO\n\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tO\nrevenue\tO\ngains\tO\nat\tO\nits\tO\nmagazines\tO\nand\tO\ninserts\tO\ndivision\tO\nwere\tO\noffset\tO\nby\tO\nhigher\tO\npaper\tO\nprices\tO\nand\tO\nlower\tO\nsales\tO\nat\tO\nthe\tO\nU.S.\tB-LOC\nTV\tB-ORG\nGuide\tI-ORG\n.\tO\n\nNews\tB-ORG\nsaid\tO\ndramatically\tO\nlower\tO\nearnings\tO\nfrom\tO\nthe\tO\nBritish\tB-MISC\narm\tO\nof\tO\nits\tO\nHarper-Collins\tB-ORG\npublishing\tO\ndivision\tO\nmore\tO\nthan\tO\noffset\tO\nhealthy\tO\nresults\tO\nfrom\tO\nits\tO\nU.S.\tB-LOC\noperation\tO\n.\tO\n\nIt\tO\nsaid\tO\nthe\tO\ndemise\tO\nof\tO\nthe\tO\nNet\tB-MISC\nBook\tI-MISC\nAgreement\tI-MISC\nhad\tO\nhurt\tO\nthe\tO\nBritish\tB-MISC\noperations\tO\n,\tO\nand\tO\nweak\tO\nperformances\tO\nfrom\tO\nthe\tO\nSan\tB-LOC\nFrancisco\tI-LOC\nunit\tO\nof\tO\nHarper-Collins\tB-ORG\nhad\tO\nnot\tO\nhelped\tO\n.\tO\n\n\"\tO\nIf\tO\nthey\tO\n're\tO\nsaying\tO\nat\tO\nleast\tO\n20\tO\npercent\tO\n,\tO\nthen\tO\ntheir\tO\ninternal\tO\nforecasts\tO\nare\tO\nprobably\tO\nsaying\tO\n25\tO\nor\tO\n30\tO\npercent\tO\n,\tO\n\"\tO\nsaid\tO\none\tO\nSydney\tB-LOC\nmedia\tO\nanalyst\tO\nwho\tO\ndeclined\tO\nto\tO\nbe\tO\nnamed\tO\n.\tO\n\nNews\tB-ORG\nCorp\tI-ORG\n's\tO\nshares\tO\nwere\tO\ndown\tO\neight\tO\ncents\tO\nat\tO\nA$\tB-MISC\n6.39\tO\nat\tO\n2.00\tO\np.m.\tO\n(\tO\n0400\tO\nGMT\tB-MISC\n)\tO\nin\tO\na\tO\nsoft\tO\nmarket\tO\n.\tO\n\n(\tO\nA$\tO\n1\tO\n=\tO\nUS$\tB-MISC\n0.79\tO\n)\tO\n\nRTRS\tB-ORG\n-\tO\nBudget\tO\ncuts\tO\nto\tO\nboost\tO\nAustralia\tB-LOC\nsavings\tO\n-\tO\nRBA\tB-ORG\n.\tO\n\nThe\tO\nAustralian\tB-MISC\ngovernment\tO\n's\tO\nplans\tO\nto\tO\nslash\tO\nits\tO\nbudget\tO\ndeficit\tO\nshould\tO\nmake\tO\na\tO\nuseful\tO\ncontribution\tO\nto\tO\nnational\tO\nsavings\tO\n,\tO\nthe\tO\nReserve\tB-ORG\nBank\tI-ORG\nof\tI-ORG\nAustralia\tI-ORG\n(\tO\nRBA\tB-ORG\n)\tO\nsaid\tO\nin\tO\nits\tO\nannual\tO\nreport\tO\n.\tO\n\n\"\tO\nThe\tO\ngovernment\tO\n's\tO\nannounced\tO\nplans\tO\nto\tO\nbalance\tO\nthe\tO\nbudget\tO\n,\tO\nif\tO\nrealised\tO\n,\tO\nwould\tO\nmake\tO\na\tO\nuseful\tO\ncontribution\tO\nto\tO\nraising\tO\nnational\tO\nsavings\tO\n,\tO\n\"\tO\nthe\tO\nRBA\tB-ORG\nsaid\tO\n.\tO\n\nIn\tO\nits\tO\n1996/97\tO\nbudget\tO\nannounced\tO\non\tO\nTuesday\tO\n,\tO\nthe\tO\nAustralian\tB-MISC\nCoalition\tB-ORG\ngovernment\tO\nannounced\tO\nan\tO\nunderlying\tO\nbudget\tO\ndeficit\tO\nof\tO\nA$\tB-MISC\n5.65\tO\nbillion\tO\n,\tO\nand\tO\npledged\tO\nto\tO\nreturn\tO\nthe\tO\nunderlying\tO\nbudget\tO\nbalance\tO\nto\tO\nsurplus\tO\nby\tO\n1998/99\tO\n.\tO\n\nThe\tO\nbudget\tO\ndeficit\tO\nwas\tO\nA$\tB-MISC\n10.3\tO\nbillion\tO\nin\tO\n1995/96\tO\n.\tO\n\n\"\tO\nMore\tO\ngenerally\tO\n,\tO\nthe\tO\nlong-term\tO\neffects\tO\nof\tO\nfiscal\tO\nconsolidation\tO\nare\tO\nclearly\tO\npositive\tO\n,\tO\nwith\tO\nhigher\tO\nsaving\tO\ntending\tO\nto\tO\npromote\tO\neconomic\tO\ngrowth\tO\nby\tO\nraising\tO\ninvestment\tO\nand\tO\nlowering\tO\nlong-term\tO\nreal\tO\ninterest\tO\nrates\tO\n,\tO\n\"\tO\nthe\tO\nRBA\tB-ORG\nsaid\tO\n.\tO\n\nBNZ\tB-ORG\ncuts\tO\nNZ\tB-LOC\nfixed\tO\nhome\tO\nlending\tO\nrates\tO\n.\tO\n\nBank\tB-ORG\nof\tI-ORG\nNew\tI-ORG\nZealand\tI-ORG\nsaid\tO\non\tO\nThursday\tO\nit\tO\nwas\tO\ncutting\tO\nits\tO\nfixed\tO\nhome\tO\nlending\tO\nrates\tO\n.\tO\n\nBNZ\tB-ORG\nsaid\tO\nit\tO\nwas\tO\nresponding\tO\nto\tO\nlower\tO\nwholesale\tO\nrates\tO\n.\tO\n\n--\tO\nWellington\tB-LOC\nnewsroom\tO\n64\tO\n4\tO\n4734\tO\n746\tO\n\nPower\tB-ORG\nNZ\tI-ORG\nODV\tI-ORG\nup\tO\n8\tO\npct\tO\nat\tO\nNZ$\tB-MISC\n524\tO\nmillion\tO\n.\tO\n\nPower\tB-ORG\nNew\tI-ORG\nZealand\tI-ORG\nsaid\tO\non\tO\nThursday\tO\nthat\tO\nthe\tO\nOptimised\tO\nDeprival\tO\nValue\tO\n(\tO\nODV\tO\n)\tO\nof\tO\nits\tO\nnetwork\tO\nat\tO\nMarch\tO\n31\tO\n,\tO\n1996\tO\nhas\tO\nbeen\tO\nset\tO\nat\tO\n$\tO\n524.2\tO\nmillion\tO\n,\tO\nan\tO\nincrease\tO\nof\tO\neight\tO\npercent\tO\non\tO\nits\tO\n$\tO\n486.5\tO\nmillion\tO\nvaluation\tO\na\tO\nyear\tO\nearlier\tO\n.\tO\n\nrequirements\tO\nof\tO\nthe\tO\nMinistry\tB-ORG\nof\tI-ORG\nCommerce\tI-ORG\n.\tO\n\nThais\tO\nhunt\tO\nfor\tO\nAustralian\tB-MISC\njail\tO\nbreaker\tO\n.\tO\n\nThailand\tB-LOC\nhas\tO\nlaunched\tO\na\tO\nmanhunt\tO\nfor\tO\nan\tO\nAustralian\tB-MISC\nwho\tO\nescaped\tO\nfrom\tO\na\tO\nhigh\tO\nsecurity\tO\nprison\tO\nin\tO\nBangkok\tB-LOC\nwhile\tO\nawaiting\tO\ntrial\tO\non\tO\ndrug\tO\npossession\tO\ncharges\tO\n,\tO\nofficials\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nDaniel\tB-PER\nWestlake\tI-PER\n,\tO\n46\tO\n,\tO\nfrom\tO\nVictoria\tB-LOC\n,\tO\nmade\tO\nthe\tO\nfirst\tO\nsucessful\tO\nescape\tO\nfrom\tO\nKlongprem\tB-LOC\nprison\tO\nin\tO\nthe\tO\nnorthern\tO\noutskirts\tO\nof\tO\nthe\tO\ncapital\tO\non\tO\nSunday\tO\nnight\tO\n.\tO\n\nHe\tO\nwas\tO\nbelieved\tO\nby\tO\nprison\tO\nofficials\tO\nto\tO\nstill\tO\nbe\tO\nin\tO\nThailand\tB-LOC\n.\tO\n\n\"\tO\nWe\tO\nhave\tO\nordered\tO\na\tO\nmassive\tO\nhunt\tO\nfor\tO\nhim\tO\nand\tO\nI\tO\nam\tO\nquite\tO\nconfident\tO\nwe\tO\nwill\tO\nget\tO\nhim\tO\nsoon\tO\n,\tO\n\"\tO\nVivit\tB-PER\nChatuparisut\tI-PER\n,\tO\ndeputy\tO\ndirector\tO\ngeneral\tO\nof\tO\nthe\tO\nCorrection\tB-ORG\nDepartment\tI-ORG\n,\tO\ntold\tO\nReuters\tB-ORG\n.\tO\n\nWestlake\tB-PER\n,\tO\narrested\tO\nin\tO\nDecember\tO\n1993\tO\nand\tO\ncharged\tO\nwith\tO\nheroin\tO\ntrafficking\tO\n,\tO\nsawed\tO\nthe\tO\niron\tO\ngrill\tO\noff\tO\nhis\tO\ncell\tO\nwindow\tO\nand\tO\nclimbed\tO\ndown\tO\nthe\tO\nprison\tO\n's\tO\nfive-metre\tO\n(\tO\n15-foot\tO\n)\tO\nwall\tO\non\tO\na\tO\nrope\tO\nmade\tO\nfrom\tO\nbed\tO\nsheets\tO\n,\tO\nVivit\tO\nsaid\tO\n.\tO\n\nThere\tO\nare\tO\n266\tO\nWesterners\tB-MISC\n,\tO\nincluding\tO\nsix\tO\nAustralians\tB-MISC\n,\tO\nin\tO\nthe\tO\nprison\tO\n,\tO\nmost\tO\nawaiting\tO\ntrial\tO\non\tO\ndrugs\tO\ncharges\tO\n.\tO\n\nThere\tO\nalso\tO\nare\tO\nabout\tO\n5,000\tO\nThai\tB-MISC\ninmates\tO\nin\tO\nKlongprem\tB-LOC\n,\tO\na\tO\nprison\tO\nofficial\tO\nsaid\tO\n.\tO\n\nTokyo\tB-ORG\nSoir\tI-ORG\n-\tO\n1996\tO\nparent\tO\nforecast\tO\n.\tO\n\nNOTE\tO\n-\tO\nTokyo\tB-ORG\nSoir\tI-ORG\nCo\tI-ORG\nLtd\tI-ORG\nis\tO\na\tO\nspecialised\tO\nmanufacturer\tO\nof\tO\nwomen\tO\n\"\tO\ns\tO\nformal\tO\nwear\tO\n.\tO\n\nKa\tB-ORG\nWah\tI-ORG\nBank\tI-ORG\nsets\tO\nHK$\tB-MISC\n43\tO\nmln\tO\nFRCD\tO\n.\tO\n\nKa\tB-ORG\nWah\tI-ORG\nBank\tI-ORG\n's\tO\nHK$\tB-MISC\n43\tO\nmillion\tO\nfloating\tO\nrate\tO\ncertificate\tO\nof\tO\ndeposit\tO\nissue\tO\nhas\tO\nbeen\tO\nprivately\tO\nplaced\tO\n,\tO\nsole\tO\narranger\tO\nHSBC\tB-ORG\nMarkets\tI-ORG\nsaid\tO\n.\tO\n\nIt\tO\npays\tO\na\tO\ncoupon\tO\nof\tO\n15\tO\nbasis\tO\npoints\tO\nover\tO\nthe\tO\nsix-month\tO\nHong\tB-ORG\nKong\tI-ORG\nInterbank\tI-ORG\nOffered\tO\nRate\tO\n.\tO\n\nClearing\tO\nis\tO\nthrough\tO\nthe\tO\nHong\tB-ORG\nKong\tI-ORG\nCentral\tI-ORG\nMoneymarkets\tI-ORG\nUnit\tI-ORG\n.\tO\n\nMalaysia\tB-LOC\nbans\tO\nnitrofuran\tO\nusage\tO\nin\tO\nchicken\tO\nfeed\tO\n.\tO\n\nMalaysia\tB-LOC\nhas\tO\nbanned\tO\nthe\tO\nuse\tO\nof\tO\nnitrofuran\tO\n,\tO\nan\tO\nantibiotic\tO\n,\tO\nin\tO\nchicken\tO\nfeed\tO\nand\tO\nveterinary\tO\napplications\tO\nbecause\tO\nit\tO\nbelieves\tO\nthe\tO\ndrug\tO\ncould\tO\ncause\tO\ncancer\tO\n,\tO\nthe\tO\nhealth\tO\nministry\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nIt\tO\nis\tO\nhoped\tO\nthat\tO\nlivestock\tO\nbreeders\tO\nand\tO\nfeedmillers\tO\nwill\tO\nabide\tO\nby\tO\nthe\tO\nlaws\tO\nand\tO\nrespect\tO\nthe\tO\ncabinet\tO\ndecision\tO\nin\tO\nthe\tO\ninterest\tO\nof\tO\nconsumer\tO\nsafety\tO\n,\tO\n\"\tO\nHealth\tO\nMinister\tO\nChua\tB-PER\nJui\tI-PER\nMeng\tO\nwas\tO\nquoted\tO\nas\tO\nsaying\tO\nby\tO\nthe\tO\nnational\tO\nBernama\tB-ORG\nnews\tO\nagency\tO\n.\tO\n\nChua\tB-PER\nsaid\tO\noffenders\tO\ncould\tO\nface\tO\na\tO\ntwo-year\tO\nprison\tO\nsentence\tO\nand\tO\na\tO\nmaximum\tO\nfine\tO\nof\tO\n5,000\tO\nringgit\tO\n(\tO\n$\tO\n2000\tO\n)\tO\n.\tO\n\nINDONESIAN\tB-MISC\nSTOCKS\tO\n-\tO\nfactors\tO\nto\tO\nwatch\tO\n-\tO\nAugust\tO\n22\tO\n.\tO\n\nFollowing\tO\nare\tO\nsome\tO\nof\tO\nthe\tO\nmain\tO\nfactors\tO\nlikely\tO\nto\tO\naffect\tO\nIndonesian\tB-MISC\nstocks\tO\non\tO\nThursday\tO\n:\tO\n\n**\tO\nSecurity\tO\nwas\tO\ntight\tO\nin\tO\nJakarta\tB-LOC\nahead\tO\nof\tO\na\tO\ntrial\tO\ninvolving\tO\nousted\tO\nIndonesian\tB-ORG\nDemocratic\tI-ORG\nParty\tI-ORG\nleader\tO\nMegawati\tB-PER\nSukarnoputri\tI-PER\n.\tO\n\nAround\tO\n200\tO\npolice\tO\nand\tO\ntroops\tO\nwere\tO\nstationed\tO\noutside\tO\nthe\tO\ncourt\tO\nin\tO\ncentral\tO\nJakarta\tB-LOC\nbut\tO\nthere\tO\nwas\tO\nno\tO\nsign\tO\nof\tO\ndemonstrators\tO\n.\tO\n\n**\tO\nThe\tO\nDow\tB-MISC\nJones\tI-MISC\nindustrial\tO\naverage\tO\nclosed\tO\ndown\tO\n31.44\tO\npoints\tO\nat\tO\n5,689.82\tO\non\tO\nWednesday\tO\n,\tO\nending\tO\na\tO\nthree-session\tO\nwinning\tO\nstreak\tO\nas\tO\ninvestors\tO\ntook\tO\nprofits\tO\nand\tO\ntobacco\tO\nstocks\tO\ntook\tO\na\tO\nbeating\tO\n.\tO\n\n**\tO\nThe\tO\nJakarta\tB-LOC\ncomposite\tO\nindex\tO\nrose\tO\n2.60\tO\npoints\tO\n,\tO\nor\tO\n0.48\tO\npercent\tO\n,\tO\nto\tO\n542.20\tO\npoints\tO\non\tO\nWednesday\tO\non\tO\nthe\tO\nback\tO\nof\tO\nbargain-hunting\tO\nin\tO\nselected\tO\nbig-capitalised\tO\nstocks\tO\nand\tO\nsecondliners\tO\n.\tO\n\n**\tO\nOn\tO\nThursday\tO\n,\tO\nthe\tO\nIndonesian\tB-MISC\nrupiah\tO\nwas\tO\nat\tO\n2,343.00\tO\n/\tO\n43.50\tO\nin\tO\nearly\tO\ntrading\tO\nagainst\tO\nan\tO\nopening\tO\nof\tO\n2,342.75\tO\n/\tO\n43.50\tO\n.\tO\n\n**\tO\nPackaging\tO\nmanufacturer\tO\nSuper\tB-ORG\nIndah\tI-ORG\nMakmur\tI-ORG\non\tO\nannouncement\tO\nof\tO\na\tO\ntender\tO\noffer\tO\nby\tO\nPT\tB-ORG\nVDH\tI-ORG\nTeguh\tI-ORG\nSakti\tI-ORG\n,\tO\na\tO\nwholly-owned\tO\nsubsidiary\tO\nof\tO\nSingapore-listed\tB-MISC\nVan\tB-ORG\nDer\tI-ORG\nHorst\tI-ORG\n.\tO\n\n**\tO\nPrivately-owned\tO\nBank\tB-ORG\nDuta\tI-ORG\non\tO\nmarket\tO\ntalk\tO\nthat\tO\nit\tO\nis\tO\nobtaining\tO\nfresh\tO\nsyndicated\tO\nloans\tO\n,\tO\na\tO\nmanagement\tO\nreshuffle\tO\nand\tO\nfresh\tO\nequity\tO\ninjection\tO\n.\tO\n\n**\tO\nCiputra\tB-ORG\nDevelopment\tI-ORG\non\tO\nreports\tO\nof\tO\na\tO\nplan\tO\nto\tO\nbuild\tO\nproperty\tO\nprojects\tO\nworth\tO\n$\tO\n2\tO\nbillion\tO\nin\tO\nJakarta\tB-LOC\nand\tO\nSurabaya\tB-LOC\n.\tO\n\nKey\tO\nstock\tO\nand\tO\ncurrency\tO\nmarket\tO\nmovements\tO\nat\tO\n1600\tO\nGMT\tB-MISC\n.\tO\n\nAlso\tO\nshown\tO\nare\tO\nthe\tO\nLondon\tB-LOC\nclosing\tO\nvalues\tO\nof\tO\nthe\tO\nGerman\tB-MISC\nmark\tO\n,\tO\nthe\tO\nJapanese\tB-MISC\nyen\tO\n,\tO\nthe\tO\nBritish\tB-MISC\npound\tO\nand\tO\ngold\tO\nbullion\tO\n(\tO\nprevious\tO\nday\tO\n's\tO\ncloses\tO\nin\tO\nbrackets\tO\n)\tO\n:\tO\n\nLONDON\tB-LOC\n3,907.5\tO\n+16.4\tO\n3,907.5\tO\n3,632.3\tO\n\nTOKYO\tB-LOC\n21,228.80\tO\n-\tO\n134.44\tO\n22,666.80\tO\n19,734.70\tO\n\nFRANKFURT\tB-LOC\n2,555.16\tO\n-\tO\n2.10\tO\n2,583.49\tO\n)\tO\n2,284.86\tO\n\nPARIS\tB-LOC\n2,020.82\tO\n+3.06\tO\n2,146.79\tO\n1,897.85\tO\n\nHONG\tB-LOC\nKONG\tI-LOC\n11,424.64\tO\n-\tO\n54.13\tO\n11,594.99\tO\n10,204.87\tO\n\nFOREIGN\tO\nEXCHANGE\tO\n/\tO\nGOLD\tO\nBULLION\tO\nCLOSE\tO\nIN\tO\nLONDON\tB-LOC\n\nNew\tB-LOC\nYork\tI-LOC\nDow\tB-MISC\nJones\tI-MISC\nindustrial\tO\naverage\tO\n--\tO\n5,778.00\tO\n(\tO\nMay\tO\n22/96\tO\n)\tO\n\nLondon\tB-LOC\nFTSE-100\tB-MISC\nindex\tO\n--\tO\n3,907.5\tO\n(\tO\nAug\tO\n23/96\tO\n)\tO\n\nTokyo\tB-LOC\nNikkei\tB-MISC\naverage\tO\n--\tO\n38,915.87\tO\n(\tO\nDec\tO\n29/89\tO\n)\tO\n\nFrankfurt\tB-LOC\nDAX-3O\tB-MISC\nindex\tO\n--\tO\n2,583.49\tO\n(\tO\nJul\tO\n5/96\tO\n)\tO\n\nParis\tB-LOC\nCAC-40\tB-MISC\nGeneral\tI-MISC\nindex\tO\n--\tO\n2,355.93\tO\n(\tO\nFeb\tO\n2/94\tO\n)\tO\n\nSydney\tB-LOC\nAustralian\tB-MISC\nAll-Ordinaries\tI-MISC\nindex\tO\n--\tO\n2,340.6\tO\n(\tO\nFeb\tO\n3/94\tO\n)\tO\n\nHong\tB-LOC\nKong\tI-LOC\nHang\tB-MISC\nSeng\tI-MISC\nindex\tO\n--\tO\n12,201.09\tO\n(\tO\nJan\tO\n4/94\tO\n)\tO\n\nUkraine\tB-LOC\nhails\tO\npeace\tO\nas\tO\nmarks\tO\nfive-year\tO\nindependence\tO\n.\tO\n\nUkraine\tB-LOC\ncelebrates\tO\nfive\tO\nyears\tO\nof\tO\nindependence\tO\nfrom\tO\nKremlin\tB-LOC\nrule\tO\non\tO\nSaturday\tO\n,\tO\nhailing\tO\ncivil\tO\nand\tO\ninter-ethnic\tO\npeace\tO\nas\tO\nits\tO\nmain\tO\npost-Soviet\tB-MISC\nachievement\tO\n.\tO\n\nUkraine\tB-LOC\n's\tO\ndeclaration\tO\nof\tO\nindependence\tO\nin\tO\n1991\tO\n,\tO\nbacked\tO\nnine-to-one\tO\nby\tO\na\tO\nreferendum\tO\nin\tO\nDecember\tO\nof\tO\nthat\tO\nyear\tO\n,\tO\neffectively\tO\ndealt\tO\na\tO\ndeath\tO\nblow\tO\nto\tO\nthe\tO\nSoviet\tB-MISC\nempire\tO\nand\tO\nended\tO\nmore\tO\nthan\tO\nthree\tO\ncenturies\tO\nof\tO\nrule\tO\nfrom\tO\nMoscow\tB-LOC\n.\tO\n\nUkraine\tB-LOC\n,\tO\nwith\tO\na\tO\nRussian\tB-MISC\ncommunity\tO\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tO\nRussia\tB-LOC\n--\tO\nhas\tO\navoided\tO\nconflicts\tO\nlike\tO\nthose\tO\nin\tO\nRussia\tB-LOC\n's\tO\nChechnya\tB-LOC\n,\tO\nneighbouring\tO\nMoldova\tB-LOC\n,\tO\nand\tO\nthe\tO\nformer\tO\nSoviet\tB-MISC\nrepublics\tO\nof\tO\nGeorgia\tB-LOC\n,\tO\nAzerbaijan\tB-LOC\nand\tO\nTajikistan\tB-LOC\n.\tO\n\n\"\tO\nUkraine\tB-LOC\n's\tO\nbiggest\tO\nachievements\tO\nfor\tO\nfive\tO\nyears\tO\nare\tO\nthe\tO\npreservation\tO\nof\tO\ncivil\tO\npeace\tO\nand\tO\ninter-ethnic\tO\nharmony\tO\n,\tO\n\"\tO\nPresident\tO\nLeonid\tB-PER\nKuchma\tI-PER\nsaid\tO\nin\tO\ntelevised\tO\nstatement\tO\nthis\tO\nweek\tO\n.\tO\n\n\"\tO\nUnlike\tO\nmany\tO\nother\tO\npost-Soviet\tB-MISC\ncountries\tO\nwe\tO\nwere\tO\nable\tO\nto\tO\ndeal\tO\nwith\tO\nconflict\tO\nsituations\tO\nin\tO\na\tO\npeaceful\tO\nand\tO\ncivilised\tO\nway\tO\n.\tO\n\"\tO\n\nKuchma\tB-PER\ntold\tO\na\tO\nsolemn\tO\nceremony\tO\nat\tO\nthe\tO\nUkraina\tB-LOC\nPalace\tI-LOC\non\tO\nFriday\tO\nthat\tO\n\"\tO\nthere\tO\nwas\tO\na\tO\nturning\tO\npoint\tO\n\"\tO\nin\tO\nreforms\tO\nand\tO\nthat\tO\nhe\tO\nexpected\tO\na\tO\nrise\tO\nin\tO\nthe\tO\nstandard\tO\nof\tO\nliving\tO\nin\tO\nthe\tO\nnear\tO\nfuture\tO\n.\tO\n\n\"\tO\nThere\tO\nis\tO\nno\tO\ndoubt\tO\nthat\tO\neconomic\tO\ngrowth\tO\nhas\tO\nalready\tO\nstarted\tO\n,\tO\n\"\tO\nsaid\tO\nAdelbert\tB-PER\nKnobl\tI-PER\n,\tO\nhead\tO\nof\tO\nthe\tO\nInternational\tB-ORG\nMonetary\tI-ORG\nFund\tI-ORG\n's\tO\nmission\tO\nin\tO\nUkraine\tB-LOC\n.\tO\n\"\tO\n\nIt\tO\nwill\tO\nreplace\tO\nthe\tO\ninterim\tO\nkarbovanets\tO\ncurrency\tO\n,\tO\nwhich\tO\nwas\tO\nintroduced\tO\nat\tO\npar\tO\nto\tO\nthe\tO\nRussian\tB-MISC\nrouble\tO\nin\tO\n1992\tO\nbut\tO\nnow\tO\ntrades\tO\nat\tO\nalmost\tO\n33\tO\nkarbovanets\tO\nper\tO\nrouble\tO\n.\tO\n\nUkraine\tB-LOC\nhas\tO\nrepeatedly\tO\npromised\tO\nto\tO\nintroduce\tO\nthe\tO\nhryvna\tO\nbut\tO\nhad\tO\nto\tO\npostpone\tO\nthe\tO\nplans\tO\nbecause\tO\nof\tO\neconomic\tO\nproblems\tO\n.\tO\n\nProud\tO\nof\tO\nits\tO\nrecord\tO\nin\tO\npromptly\tO\njoining\tO\nboth\tO\nthe\tO\nCouncil\tB-ORG\nof\tI-ORG\nEurope\tI-ORG\nand\tO\nNATO\tB-ORG\n's\tO\nPartnership\tB-MISC\nfor\tI-MISC\nPeace\tI-MISC\n,\tO\nUkraine\tB-LOC\ncaused\tO\na\tO\nforeign\tO\npolicy\tO\nwrangle\tO\nthis\tO\nweek\tO\n,\tO\noffending\tO\nChina\tB-LOC\nby\tO\nallowing\tO\na\tO\nTaiwanese\tB-MISC\nminister\tO\nto\tO\nappear\tO\non\tO\na\tO\npublic\tO\n,\tO\nif\tO\nunofficial\tO\nvisit\tO\n.\tO\n\nChina\tB-LOC\ncancelled\tO\na\tO\nvisit\tO\nby\tO\na\tO\ntop-level\tO\ndelegation\tO\nin\tO\nprotest\tO\n.\tO\n\nKiev\tB-LOC\n's\tO\nForeign\tO\nMinister\tO\nHennady\tB-PER\nUdovenko\tI-PER\nsaid\tO\nBeijing\tO\nwas\tO\noverreacting\tO\n.\tO\n\nBut\tO\nUkraine\tB-LOC\n,\tO\nseeing\tO\nitself\tO\nas\tO\na\tO\nbridge\tO\nbetween\tO\nRussia\tB-LOC\nand\tO\nthe\tO\nrapidly\tO\nWesternising\tB-MISC\ncountries\tO\nof\tO\neastern\tO\nEurope\tB-LOC\n,\tO\nis\tO\nlooking\tO\nWest\tO\nas\tO\nwell\tO\nas\tO\nEast\tO\n.\tO\n\n\"\tO\nThe\tO\nstrategic\tO\naim\tO\nof\tO\nEuropean\tB-MISC\nintegration\tO\nshould\tO\nnot\tO\nin\tO\nany\tO\nway\tO\ndamage\tO\nUkraine\tB-LOC\n's\tO\ninterests\tO\nin\tO\npost-Soviet\tB-MISC\nareas\tO\n.\tO\n\nRelations\tO\nwith\tO\nRussia\tB-LOC\n,\tO\nwhich\tO\nis\tO\nour\tO\nmain\tO\npartner\tO\n,\tO\nhave\tO\ngreat\tO\nimportance\tO\n,\tO\n\"\tO\nKuchma\tB-PER\nsaid\tO\n.\tO\n\n\"\tO\nBut\tO\nUkraine\tB-LOC\ncannot\tO\nbe\tO\neconomically\tO\noriented\tO\non\tO\nRussia\tB-LOC\n,\tO\neven\tO\nthough\tO\nthose\tO\nin\tO\nsome\tO\ncircles\tO\npush\tO\nus\tO\nto\tO\ndo\tO\nthat\tO\n.\tO\n\"\tO\n\nKuchma\tB-PER\nhas\tO\nsaid\tO\nKiev\tB-LOC\nwants\tO\nmembership\tO\nof\tO\nthe\tO\nEuropean\tB-ORG\nUnion\tI-ORG\n,\tO\nassociate\tO\nmembership\tO\nof\tO\nthe\tO\nWestern\tB-ORG\nEuropean\tI-ORG\nUnion\tI-ORG\ndefence\tO\ngrouping\tO\nand\tO\nto\tO\nmove\tO\ncloser\tO\nto\tO\nNATO\tB-ORG\n.\tO\n\nA\tO\nmessage\tO\nfrom\tO\nthe\tO\nWest\tO\nthis\tO\nweek\tO\nfrom\tO\nU.S.\tB-LOC\nPresident\tO\nBill\tB-PER\nClinton\tI-PER\ncongratulated\tO\nUkraine\tB-LOC\non\tO\nthe\tO\nanniversary\tO\n,\tO\npromising\tO\nto\tO\nsupport\tO\nmarket\tO\nreforms\tO\nand\tO\npraising\tO\nUkraine\tB-LOC\nas\tO\na\tO\n\"\tO\nstabilising\tO\nfactor\tO\n\"\tO\nin\tO\na\tO\nunited\tO\nEurope\tB-LOC\n.\tO\n\nOldest\tO\nAlbania\tB-LOC\nbook\tO\ndisappears\tO\nfrom\tO\nVatican\tB-LOC\n-\tO\npaper\tO\n.\tO\n\nA\tO\n16th-century\tO\ndocument\tO\n,\tO\nthe\tO\nearliest\tO\ncomplete\tO\nexample\tO\nof\tO\nwritten\tO\nAlbanian\tB-MISC\n,\tO\nhas\tO\ndisappeared\tO\nfrom\tO\nthe\tO\nVatican\tB-LOC\narchives\tO\n,\tO\nan\tO\nAlbanian\tB-MISC\nnewspaper\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nGazeta\tB-ORG\nShqiptare\tI-ORG\nsaid\tO\nthe\tO\n\"\tO\nBook\tB-MISC\nof\tI-MISC\nMass\tI-MISC\n'\tO\n,\tO\nby\tO\nGjon\tB-PER\nBuzuku\tI-PER\n,\tO\ndating\tO\nfrom\tO\n1555\tO\nand\tO\ndiscovered\tO\nin\tO\n1740\tO\nin\tO\na\tO\nreligious\tO\nseminary\tO\nin\tO\nRome\tB-LOC\n,\tO\nwas\tO\nthe\tO\nfirst\tO\nmajor\tO\ndocument\tO\npublished\tO\nin\tO\nthe\tO\nAlbanian\tB-MISC\nlanguage\tO\n.\tO\n\n\"\tO\nWe\tO\nAlbanians\tB-MISC\n,\tO\nsons\tO\nof\tO\nBuzuku\tB-MISC\n,\tO\nbelieved\tO\nour\tO\nlanguage\tO\nhad\tO\na\tO\nwritten\tO\ndocument\tO\nbut\tO\nnow\tO\nwe\tO\ndo\tO\nnot\tO\nhave\tO\nit\tO\nany\tO\nmore\tO\n,\tO\n\"\tO\nlamented\tO\nscholar\tO\nMusa\tB-PER\nHamiti\tI-PER\n,\tO\ntold\tO\nof\tO\nthe\tO\nloss\tO\nby\tO\nthe\tO\nVatican\tB-LOC\nlibrary\tO\n.\tO\n\nTirana\tB-LOC\n's\tO\nnational\tO\nlibrary\tO\nhas\tO\nthree\tO\ncopies\tO\nof\tO\nthe\tO\n\"\tO\nBook\tB-MISC\nof\tI-MISC\nMass\tI-MISC\n'\tO\n.\tO\n\"\tO\n\nThere\tO\nis\tO\nnothing\tO\nleft\tO\nfor\tO\nus\tO\nbut\tO\nto\tO\nbe\tO\ngrateful\tO\nto\tO\ncivilisation\tO\nfor\tO\ninventing\tO\nphotocopies\tO\n,\tO\n\"\tO\nGazeta\tB-ORG\nShqiptare\tI-ORG\nsaid\tO\n.\tO\n\nRussian\tB-MISC\nofficials\tO\n,\tO\nkeen\tO\nto\tO\ncut\tO\ncapital\tO\nflight\tO\n,\tO\nwill\tO\nadopt\tO\ntight\tO\nmeasures\tO\nto\tO\ncut\tO\nbarter\tO\ndeals\tO\nin\tO\nforeign\tO\ntrade\tO\nto\tO\na\tO\nminimum\tO\n,\tO\na\tO\ncustoms\tO\nofficial\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\n\"\tO\nWe\tO\nhave\tO\nalways\tO\nbeen\tO\nconcerned\tO\nabout\tO\nbarter\tO\ndeals\tO\nwith\tO\nother\tO\ncountries\tO\n,\tO\nviewing\tO\nthem\tO\nas\tO\na\tO\ndisguised\tO\nkind\tO\nof\tO\ncapital\tO\nflight\tO\nfrom\tO\nRussia\tB-LOC\n,\tO\n\"\tO\nMarina\tB-PER\nVolkova\tI-PER\n,\tO\ndeputy\tO\nhead\tO\nof\tO\nthe\tO\ncurrency\tO\ndepartment\tO\nat\tO\nthe\tO\nState\tB-ORG\nCustoms\tI-ORG\nCommittee\tI-ORG\n,\tO\ntold\tO\nReuters\tB-ORG\n.\tO\n\nVolkova\tO\nsaid\tO\nlast\tO\nyear\tO\ngoods\tO\nhad\tO\nbeen\tO\nexported\tO\nunder\tO\nmany\tO\nRussian\tB-MISC\nbarter\tO\ndeals\tO\n,\tO\nwith\tO\nnothing\tO\nimported\tO\nin\tO\nreturn\tO\n.\tO\n\nBarter\tO\ndeals\tO\nwere\tO\nworth\tO\n$\tO\n4.9\tO\nbillion\tO\nlast\tO\nyear\tO\n,\tO\nor\tO\nabout\tO\neight\tO\npercent\tO\nof\tO\nall\tO\nRussian\tB-MISC\nexports\tO\nestimated\tO\nat\tO\n$\tO\n61.5\tO\nbillion\tO\n,\tO\nshe\tO\nsaid\tO\n.\tO\n\n\"\tO\nThe\tO\ncost\tO\nof\tO\nexported\tO\ngoods\tO\nis\tO\ntoo\tO\noften\tO\nunderstated\tO\n,\tO\nso\tO\nthe\tO\nactual\tO\nshare\tO\nof\tO\nbarter\tO\ndeals\tO\nin\tO\nRussian\tB-MISC\nexports\tO\nand\tO\nthe\tO\namount\tO\nof\tO\nunimported\tO\ngoods\tO\nmay\tO\nbe\tO\neven\tO\nhigher\tO\n,\tO\n\"\tO\nVolkova\tB-PER\nsaid\tO\n.\tO\n\nA\tO\nfew\tO\ndays\tO\nago\tO\nRussian\tB-MISC\nPresident\tO\nBoris\tB-PER\nYeltsin\tI-PER\nissued\tO\na\tO\ndecree\tO\non\tO\nstate\tO\nregulation\tO\nof\tO\nforeign\tO\nbarter\tO\ndeals\tO\n,\tO\nand\tO\nVolkova\tB-PER\nsaid\tO\nthis\tO\n\"\tO\ncould\tO\nsubstantially\tO\nimprove\tO\nthe\tO\nsituation\tO\n\"\tO\n.\tO\n\nIn\tO\nline\tO\nwith\tO\nthe\tO\ndecree\tO\n,\tO\nwhich\tO\nwill\tO\ncome\tO\ninto\tO\nforce\tO\non\tO\nNovember\tO\n1\tO\n,\tO\nall\tO\nRussian\tB-MISC\nbarter\tO\ntraders\tO\nwill\tO\nbe\tO\nobliged\tO\nto\tO\nimport\tO\ngoods\tO\nworth\tO\nthe\tO\ncost\tO\nof\tO\ntheir\tO\nexports\tO\nwithin\tO\n180\tO\ndays\tO\n.\tO\n\n\"\tO\nIf\tO\ntraders\tO\nare\tO\nlate\tO\n,\tO\nthey\tO\nwill\tO\nhave\tO\nto\tO\npay\tO\nfines\tO\nworth\tO\nthe\tO\ncost\tO\nof\tO\ntheir\tO\nexported\tO\ngoods\tO\n,\tO\n\"\tO\nVolkova\tB-PER\nsaid\tO\n.\tO\n\nUnderstating\tO\nthe\tO\ncost\tO\nof\tO\nexported\tO\ngoods\tO\ncould\tO\nstill\tO\nbe\tO\na\tO\nloophole\tO\nfor\tO\nbarter\tO\ndealers\tO\n,\tO\nbut\tO\nVolkova\tB-PER\nsaid\tO\nthe\tO\nauthorities\tO\nare\tO\ncurrently\tO\n\"\tO\ntackling\tO\nthe\tO\ntechnicalities\tO\nof\tO\nthe\tO\nissue\tO\n\"\tO\n.\tO\n\nBarter\tO\nhas\tO\nalways\tO\nbeen\tO\na\tO\nfeature\tO\nof\tO\nthe\tO\nSoviet\tB-LOC\nUnion\tI-LOC\n's\tO\nforeign\tO\ntrade\tO\n,\tO\nbut\tO\nYeltsin\tB-PER\n's\tO\ndecrees\tO\nliberalising\tO\nforeign\tO\ntrade\tO\nin\tO\n1991-1992\tO\nhas\tO\ngiven\tO\nbarter\tO\na\tO\nnew\tO\nimpetus\tO\n.\tO\n\nA\tO\nfew\tO\nyears\tO\nago\tO\n,\tO\nbarter\tO\ndeals\tO\naccounted\tO\nfor\tO\nup\tO\nto\tO\n25-30\tO\npercent\tO\nof\tO\nRussian\tB-MISC\nexports\tO\nbecause\tO\n\"\tO\nthousands\tO\n(\tO\nof\tO\n)\tO\ntrade\tO\ncompanies\tO\nwhich\tO\npopped\tO\nup\tO\npreferred\tO\nbarter\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nreliable\tO\nRussian\tB-MISC\nbanks\tO\nand\tO\nmoney\tO\ntransfer\tO\nsystems\tO\n\"\tO\n,\tO\nVolkova\tB-PER\nsaid\tO\n.\tO\n\n\"\tO\nNow\tO\nmany\tO\nRussian\tB-MISC\nbanks\tO\nare\tO\nstrong\tO\nand\tO\ncan\tO\nmake\tO\nvarious\tO\nsorts\tO\nof\tO\nmoney\tO\ntranfers\tO\n,\tO\nwhile\tO\nincompetent\tO\ntraders\tO\nare\tO\nbeing\tO\nousted\tO\nby\tO\nmore\tO\nexperienced\tO\nones\tO\n.\tO\n\nBut\tO\nthe\tO\ncurrent\tO\nshare\tO\nof\tO\nbarter\tO\ndeals\tO\nin\tO\nRussian\tB-MISC\nexports\tO\nis\tO\nstill\tO\nhigh\tO\n,\tO\n\"\tO\nshe\tO\nsaid\tO\n.\tO\n\n--\tO\nDmitry\tB-PER\nSolovyov\tI-PER\n,\tO\nMoscow\tB-ORG\nNewsroom\tI-ORG\n,\tO\n+7095\tO\n941\tO\n8520\tO\n\nViacom\tB-ORG\nplans\tO\n\"\tO\nMission\tB-MISC\n\"\tO\nsequel\tO\n-\tO\nreport\tO\n.\tO\n\nParamount\tB-ORG\nPictures\tI-ORG\nis\tO\ngoing\tO\nahead\tO\nwith\tO\na\tO\nsequel\tO\nto\tO\nthe\tO\nTom\tB-PER\nCruise\tI-PER\nblockbuster\tO\n,\tO\n\"\tO\nMission\tB-MISC\n:\tI-MISC\nImpossible\tI-MISC\n\"\tO\nand\tO\nhopes\tO\nto\tO\nrelease\tO\nit\tO\nin\tO\nthe\tO\nsummer\tO\nof\tO\n1998\tO\n,\tO\nDaily\tB-ORG\nVariety\tI-ORG\nreported\tO\nin\tO\nits\tO\nFriday\tO\nedition\tO\n.\tO\n\nIt\tO\n's\tO\nthe\tO\nbiggest\tO\nsuccess\tO\nfor\tO\nViacom\tB-MISC\nInc-owned\tI-MISC\nParamount\tB-ORG\nsince\tO\n1994\tO\n's\tO\n\"\tO\nForrest\tB-MISC\nGump\tI-MISC\n\"\tO\n.\tO\n\nCruise\tB-PER\nwill\tO\nreprise\tO\nhis\tO\nroles\tO\nas\tO\nstar\tO\nand\tO\nco-producer\tO\n,\tO\nand\tO\nwill\tO\nsoon\tO\nmeet\tO\nAcademy\tB-MISC\nAward-winning\tI-MISC\nscreenwriter\tO\nWilliam\tB-PER\nGoldman\tI-PER\n,\tO\nwho\tO\nwill\tO\nwrite\tO\nthe\tO\nscript\tO\n,\tO\nthe\tO\nreport\tO\nsaid\tO\n.\tO\n\nIt\tO\nsaid\tO\n\"\tO\nMission\tB-MISC\n:\tI-MISC\nImpossible\tI-MISC\n\"\tO\ndirector\tO\nBrian\tB-PER\nDe\tI-PER\nPalma\tI-PER\nwould\tO\nhave\tO\nfirst\tO\ncrack\tO\nat\tO\nthe\tO\nsequel\tO\n,\tO\nthough\tO\nno\tO\ndeals\tO\nhave\tO\nbeen\tO\nmade\tO\nyet\tO\n.\tO\n\nGoldman\tB-PER\n,\tO\nwhose\tO\nOscars\tB-MISC\nwere\tO\nfor\tO\n\"\tO\nButch\tB-MISC\nCassidy\tI-MISC\nand\tI-MISC\nthe\tI-MISC\nSundance\tI-MISC\nKid\tI-MISC\n\"\tO\nand\tO\n\"\tO\nAll\tB-MISC\nthe\tI-MISC\nPresident\tI-MISC\n's\tI-MISC\nMen\tI-MISC\n\"\tO\n,\tO\nearlier\tO\nthis\tO\nsummer\tO\ncriticised\tO\nsome\tO\nof\tO\nthe\tO\nseason\tO\n's\tO\nblockbusters\tO\n.\tO\n\nHowever\tO\n,\tO\nhe\tO\nsingled\tO\nout\tO\n\"\tO\nMission\tB-MISC\n:\tI-MISC\nImpossible\tI-MISC\n\"\tO\nas\tO\nan\tO\nespecially\tO\nentertaining\tO\nmovie\tO\n,\tO\nDaily\tB-ORG\nVariety\tI-ORG\nsaid\tO\n.\tO\n\nCRICKET\tO\n-\tO\nCRAWLEY\tB-PER\nFORCED\tO\nTO\tO\nSIT\tO\nAND\tO\nWAIT\tO\n.\tO\n\nEngland\tB-LOC\nbatsman\tO\nJohn\tB-PER\nCrawley\tI-PER\nwas\tO\nforced\tO\nto\tO\nendure\tO\na\tO\nfrustrating\tO\ndelay\tO\nof\tO\nover\tO\nthree\tO\nhours\tO\nbefore\tO\nresuming\tO\nhis\tO\nquest\tO\nfor\tO\na\tO\nmaiden\tO\ntest\tO\ncentury\tO\nin\tO\nthe\tO\nthird\tO\ntest\tO\nagainst\tO\nPakistan\tB-LOC\non\tO\nFriday\tO\n.\tO\n\nHeavy\tO\novernight\tO\nrain\tO\nand\tO\nmorning\tO\ndrizzle\tO\nruled\tO\nout\tO\nany\tO\nplay\tO\nbefore\tO\nlunch\tO\non\tO\nthe\tO\nsecond\tO\nday\tO\nbut\tO\nan\tO\nimprovement\tO\nin\tO\nthe\tO\nweather\tO\nprompted\tO\nthe\tO\numpires\tO\nto\tO\nannounce\tO\na\tO\n1415\tO\nlocal\tO\ntime\tO\n(\tO\n1315\tO\nGMT\tB-MISC\n)\tO\nstart\tO\nin\tO\nthe\tO\nevent\tO\nof\tO\nno\tO\nfurther\tO\nrain\tO\n.\tO\n\nCrawley\tB-PER\n,\tO\nunbeaten\tO\non\tO\n94\tO\novernight\tO\nin\tO\nan\tO\nEngland\tB-LOC\ntotal\tO\nof\tO\n278\tO\nfor\tO\nsix\tO\n,\tO\nwas\tO\nspotted\tO\nstrumming\tO\na\tO\nguitar\tO\nin\tO\nthe\tO\ndressing-room\tO\nas\tO\nthe\tO\nOval\tB-LOC\nground\tO\nstaff\tO\ntook\tO\ncentre\tO\nstage\tO\n.\tO\n\nThere\tO\nwere\tO\nseveral\tO\ndamp\tO\npatches\tO\non\tO\nthe\tO\nsquare\tO\nand\tO\nthe\tO\noutfield\tO\nand\tO\nit\tO\nwas\tO\nstill\tO\nraining\tO\nwhen\tO\nthe\tO\nplayers\tO\ntook\tO\nan\tO\nearly\tO\nlunch\tO\nat\tO\n1230\tO\nlocal\tO\ntime\tO\n(\tO\n1130\tO\nGMT\tB-MISC\n)\tO\n.\tO\n\nWhen\tO\nbrighter\tO\nweather\tO\nfinally\tO\narrived\tO\n,\tO\nthe\tO\numpires\tO\nannounced\tO\na\tO\nrevised\tO\nfigure\tO\nof\tO\n67\tO\novers\tO\nto\tO\nbe\tO\nbowled\tO\nwith\tO\nplay\tO\nextended\tO\nto\tO\nat\tO\nleast\tO\n1900\tO\nlocal\tO\ntime\tO\n(\tO\n1800\tO\nGMT\tB-MISC\n)\tO\n.\tO\n\nMOTOR\tO\nRACING\tO\n-\tO\nBELGIAN\tB-MISC\nGRAND\tB-MISC\nPRIX\tI-MISC\nPRACTICE\tO\nTIMES\tO\n.\tO\n\nSPA-FRANCORCHAMPS\tB-LOC\n,\tO\nBelgium\tB-LOC\n1996-08-23\tO\n\nBelgian\tO\nGrand\tB-MISC\nPrix\tI-MISC\nmotor\tO\nrace\tO\n:\tO\n\n1.\tO\nGerhard\tB-PER\nBerger\tI-PER\n(\tO\nAustria\tB-LOC\n)\tO\nBenetton\tB-ORG\n1\tO\nminute\tO\n53.706\tO\nseconds\tO\n\n2.\tO\nDavid\tB-PER\nCoulthard\tI-PER\n(\tO\nBritain\tO\n)\tO\nMcLaren\tB-ORG\n1:54.342\tO\n\n3.\tO\nJacques\tB-PER\nVilleneuve\tI-PER\n(\tO\nCanada\tO\n)\tO\nWilliams\tO\n1:54.443\tO\n\n4.\tO\nMika\tO\nHakkinen\tO\n(\tO\nFinland\tB-LOC\n)\tO\nMcLaren\tO\n1:54.754\tO\n\n5.\tO\nHeinz-Harald\tB-PER\nFrentzen\tI-PER\n(\tO\nGermany\tO\n)\tO\n1:54.984\tO\n\n6.\tO\nJean\tB-PER\nAlesi\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\nBenetton\tB-ORG\n1:55.101\tO\n\n7.\tO\nDamon\tB-PER\nHill\tI-PER\n(\tO\nBritain\tB-LOC\n)\tO\nWilliams\tB-ORG\n1:55.281\tO\n\n8.\tO\nMichael\tB-PER\nSchumacher\tI-PER\n(\tO\nGermany\tO\n)\tO\n1:55.333\tO\n\n9.\tO\nMartin\tB-PER\nBrundle\tI-PER\n(\tO\nBritain\tB-LOC\n)\tO\nJordan\tB-ORG\n1:55.385\tO\n\n10.\tO\nRubens\tB-PER\nBarrichello\tI-PER\n(\tO\nBrazil\tB-LOC\n)\tO\nJordan\tB-ORG\n1:55.645\tO\n\n11.\tO\nJohnny\tB-PER\nHerbert\tI-PER\n(\tO\nBritain\tB-LOC\n)\tO\nSauber\tB-ORG\n1:56.318\tO\n\n12.\tO\nOlivier\tB-PER\nPanis\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\nLigier\tB-ORG\n1:56.417\tO\n\n$\tO\n450,000\tO\nToshiba\tB-MISC\nClassic\tI-MISC\ntennis\tO\ntournament\tO\non\tO\nThursday\tO\n(\tO\nprefix\tO\n\n2\tO\n-\tO\nConchita\tB-PER\nMartinez\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\nbeat\tO\nNathalie\tB-PER\nTauziat\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\n\n5\tO\n-\tO\nGabriela\tB-PER\nSabatini\tI-PER\n(\tO\nArgentina\tB-LOC\n)\tO\nbeat\tO\nAsa\tB-PER\nCarlsson\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\n\nKatarina\tB-PER\nStudenikova\tI-PER\n(\tO\nSlovakia\tB-LOC\n)\tO\nbeat\tO\n6\tO\n-\tO\nKarina\tB-PER\nHabsudova\tI-PER\n\n(\tO\nSlovakia\tB-LOC\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n6-2\tO\n\n(\tO\nCorrects\tO\nthat\tO\nHabsudova\tB-PER\nis\tO\nsixth\tO\nseed\tO\n)\tO\n.\tO\n\nSOCCER\tO\n-\tO\nENGLISH\tB-MISC\nFIRST\tO\nDIVISION\tO\nRESULTS\tO\n.\tO\n\nResults\tO\nof\tO\nEnglish\tB-MISC\nfirst\tO\ndivision\tO\n\nPortsmouth\tB-ORG\n1\tO\nQueens\tB-ORG\nPark\tI-ORG\nRangers\tI-ORG\n2\tO\n\nSOCCER\tO\n-\tO\nSCOTTISH\tB-MISC\nTHIRD\tO\nDIVISION\tO\nRESULT\tO\n.\tO\n\nResult\tO\nof\tO\na\tO\nScottish\tB-MISC\nthird\tO\n\nEast\tB-ORG\nStirling\tI-ORG\n0\tO\nAlbion\tB-ORG\n1\tO\n\nEnglish\tB-MISC\nCounty\tI-MISC\nChampionship\tI-MISC\ncricket\tO\nmatches\tO\non\tO\nFriday\tO\n:\tO\n\nSomerset\tB-ORG\n298-6\tO\n(\tO\nM.\tB-PER\nLathwell\tI-PER\n85\tO\n,\tO\n\nR.\tB-PER\nHarden\tI-PER\n65\tO\n)\tO\n.\tO\n\nEssex\tB-ORG\n194-0\tO\n(\tO\nG.\tB-PER\nGooch\tI-PER\n105\tO\nnot\tO\nout\tO\n,\tO\nD.\tB-PER\nRobinson\tI-PER\n\nAt\tO\nCardiff\tB-LOC\n:\tO\nKent\tB-ORG\n255-3\tO\n(\tO\nD.\tB-PER\nFulton\tI-PER\n64\tO\n,\tO\nM.\tB-PER\nWalker\tI-PER\n59\tO\n,\tO\nC.\tB-PER\nHooper\tI-PER\n\n52\tO\nnot\tO\nout\tO\n)\tO\nv\tO\nGlamorgan\tB-ORG\n.\tO\n\nAt\tO\nNorthampton\tB-LOC\n:\tO\nSussex\tB-ORG\n389\tO\n(\tO\nN.\tB-PER\nLenham\tI-PER\n145\tO\n,\tO\nV.\tB-PER\nDrakes\tI-PER\n59\tO\n,\tO\n\nA.\tB-PER\nWells\tI-PER\n51\tO\n;\tO\nA.\tB-PER\nPenberthy\tI-PER\n4-36\tO\n)\tO\n.\tO\n\nNorthamptonshire\tB-ORG\n160-4\tO\n(\tO\nK.\tO\nCurran\tO\n\nAt\tO\nWorcester\tB-LOC\n:\tO\nWarwickshire\tB-ORG\n310\tO\n(\tO\nA.\tB-PER\nGiles\tI-PER\n83\tO\n,\tO\nT.\tB-PER\nMunton\tI-PER\n54\tO\nnot\tO\n\nout\tO\n,\tO\nW.\tB-PER\nKhan\tI-PER\n52\tO\n;\tO\nR.\tB-PER\nIllingworth\tI-PER\n4-54\tO\n,\tO\nS.\tO\nLampitt\tO\n4-90\tO\n)\tO\n.\tO\n\nAt\tO\nHeadingley\tO\n:\tO\nYorkshire\tB-ORG\n529-8\tO\ndeclared\tO\n(\tO\nC.\tB-PER\nWhite\tI-PER\n181\tO\n,\tO\n\nR.\tB-PER\nBlakey\tI-PER\n109\tO\nnot\tO\nout\tO\n,\tO\nM.\tB-PER\nMoxon\tI-PER\n66\tO\n,\tO\nM.\tB-PER\nVaughan\tI-PER\n57\tO\n)\tO\n.\tO\n\n162-4\tO\n(\tO\nN.\tB-PER\nFairbrother\tI-PER\n53\tO\nnot\tO\nout\tO\n)\tO\n.\tO\n\nCRICKET\tO\n-\tO\nPOLLOCK\tB-PER\nHOPES\tO\nFOR\tO\nRETURN\tO\nTO\tO\nWARWICKSHIRE\tB-ORG\n.\tO\n\nSouth\tB-MISC\nAfrican\tI-MISC\nall-rounder\tO\nShaun\tB-PER\nPollock\tI-PER\n,\tO\nforced\tO\nto\tO\ncut\tO\nshort\tO\nhis\tO\nfirst\tO\nseason\tO\nwith\tO\nWarwickshire\tB-ORG\nto\tO\nhave\tO\nankle\tO\nsurgery\tO\n,\tO\nhas\tO\ntold\tO\nthe\tO\nEnglish\tB-MISC\ncounty\tO\nhe\tO\nwould\tO\nlike\tO\nto\tO\nreturn\tO\nlater\tO\nin\tO\nhis\tO\ncareer\tO\n.\tO\n\nPollock\tB-PER\n,\tO\nwho\tO\nreturns\tO\nhome\tO\na\tO\nmonth\tO\nearly\tO\nnext\tO\nweek\tO\n,\tO\nsaid\tO\n:\tO\n\"\tO\nI\tO\nwould\tO\nlike\tO\nto\tO\ncome\tO\nback\tO\nand\tO\nplay\tO\ncounty\tO\ncricket\tO\nin\tO\nthe\tO\nfuture\tO\nand\tO\nI\tO\ndo\tO\nn't\tO\nthink\tO\nI\tO\nwould\tO\nlike\tO\nto\tO\nswap\tO\ncounties\tO\n.\tO\n\"\tO\n\nExplaining\tO\nhis\tO\npremature\tO\ndeparture\tO\nwas\tO\nunavoidable\tO\n,\tO\nPollock\tB-PER\nsaid\tO\n:\tO\n\"\tO\nI\tO\nhave\tO\nbeen\tO\ncarrying\tO\nthe\tO\ninjury\tO\nfor\tO\na\tO\nwhile\tO\nand\tO\nI\tO\nhope\tO\nthat\tO\nby\tO\nhaving\tO\nthe\tO\nsurgery\tO\nnow\tO\nI\tO\nwill\tO\nbe\tO\nable\tO\nto\tO\nlast\tO\nout\tO\nthe\tO\nnew\tO\nseason\tO\nback\tO\nhome\tO\n.\tO\n\"\tO\n\nthe\tO\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nbetween\tO\nEngland\tB-LOC\nand\tO\nPakistan\tB-LOC\nat\tO\nThe\tB-LOC\n\nJ.\tB-PER\nCrawley\tI-PER\nb\tO\nWaqar\tB-PER\nYounis\tI-PER\n106\tO\n\nI.\tB-PER\nSalisbury\tI-PER\nc\tO\nInzamam-ul-Haq\tB-PER\nb\tO\nWasim\tB-PER\nAkram\tI-PER\n5\tO\n\nD.\tB-PER\nCork\tI-PER\nc\tO\nMoin\tB-PER\nKhan\tI-PER\nb\tO\nWaqar\tB-PER\nYounis\tI-PER\n0\tO\n\nR.\tB-PER\nCroft\tI-PER\nnot\tO\nout\tO\n5\tO\n\nA.\tB-PER\nMullally\tI-PER\nb\tO\nWasim\tB-PER\nAkram\tI-PER\n24\tO\n\nBowling\tO\n:\tO\nWasim\tB-PER\nAkram\tI-PER\n29.2-9-83-3\tO\n,\tO\nWaqar\tB-PER\nYounis\tI-PER\n25-6-95-4\tO\n,\tO\n\nMohammad\tB-PER\nAkram\tI-PER\n12-1-41-1\tO\n,\tO\nMushtaq\tO\nAhmed\tO\n27-5-78-2\tO\n,\tO\nAamir\tB-PER\nSohail\tI-PER\n\nPakistan\tB-LOC\nfirst\tO\ninnings\tO\n\nSaeed\tB-PER\nAnwar\tI-PER\nnot\tO\nout\tO\n116\tO\n\nAamir\tB-PER\nSohail\tI-PER\nc\tO\nCork\tB-PER\nb\tO\nCroft\tO\n46\tO\n\nIjaz\tB-PER\nAhmed\tI-PER\nnot\tO\nout\tO\n58\tO\n\nTo\tO\nbat\tO\n:\tO\nInzamam-ul-Haq\tB-PER\n,\tO\nSalim\tB-PER\nMalik\tI-PER\n,\tO\nAsif\tB-PER\nMujtaba\tI-PER\n,\tO\nWasim\tB-PER\n\nAkram\tB-PER\n,\tO\nMoin\tB-PER\nKhan\tI-PER\n,\tO\nMushtaq\tO\nAhmed\tO\n,\tO\nWaqar\tB-PER\nYounis\tI-PER\n,\tO\nMohammad\tB-PER\nAkam\tI-PER\n\nBowling\tO\n(\tO\nto\tO\ndate\tO\n)\tO\n:\tO\nLewis\tO\n9-1-49-0\tO\n,\tO\nMullally\tB-PER\n9-3-28-0\tO\n,\tO\nCroft\tB-PER\n\n17-3-42-1\tO\n,\tO\nCork\tB-PER\n7-1-38-0\tO\n,\tO\nSalisbury\tB-PER\n14-0-71-0\tO\n\nCRICKET\tO\n-\tO\nENGLAND\tB-LOC\n326\tO\nALL\tO\nOUT\tO\nV\tO\nPAKISTAN\tB-LOC\nIN\tO\nTHIRD\tO\nTEST\tO\n.\tO\n\nEngland\tB-LOC\nwere\tO\nall\tO\nout\tO\nfor\tO\n326\tO\nin\tO\ntheir\tO\nfirst\tO\ninnings\tO\non\tO\nthe\tO\nsecond\tO\nday\tO\nof\tO\nthe\tO\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nagainst\tO\nPakistan\tB-LOC\nat\tO\nThe\tB-LOC\nOval\tI-LOC\non\tO\nFriday\tO\n.\tO\n\nScore\tO\n:\tO\nEngland\tB-LOC\n326\tO\n(\tO\nJ.\tB-PER\nCrawley\tI-PER\n106\tO\n,\tO\nG.\tB-PER\nThorpe\tI-PER\n54\tO\n.\tO\n\nSOCCER\tO\n-\tO\nSPONSORS\tO\nCASH\tO\nIN\tO\nON\tO\nRAVANELLI\tB-PER\n'S\tO\nSHIRT\tO\nDANCE\tO\n.\tO\n\nMiddlesbrough\tB-ORG\n's\tO\nItalian\tB-MISC\nstriker\tO\nFabrizio\tB-PER\nRavanelli\tI-PER\nis\tO\nto\tO\nwear\tO\nhis\tO\nteam\tO\nsponsor\tO\n's\tO\nname\tO\non\tO\nthe\tO\ninside\tO\nof\tO\nhis\tO\nshirt\tO\nso\tO\nit\tO\ncan\tO\nbe\tO\nseen\tO\nwhen\tO\nhe\tO\nscores\tO\n.\tO\n\nEvery\tO\ntime\tO\nhe\tO\nfinds\tO\nthe\tO\nnet\tO\n,\tO\nthe\tO\ngrey-haired\tO\nforward\tO\npulls\tO\nhis\tO\nshirtfront\tO\nover\tO\nhis\tO\nhead\tO\nas\tO\nhe\tO\nruns\tO\nto\tO\nsalute\tO\nthe\tO\nfans\tO\n,\tO\nand\tO\nMiddlesbrough\tB-ORG\n's\tO\nsponsors\tO\nwant\tO\nto\tO\ncash\tO\nin\tO\non\tO\nthe\tO\nspectacle\tO\n.\tO\n\n\"\tO\nHaving\tO\nseen\tO\nRavanelli\tB-PER\ncelebrate\tO\nhis\tO\ngoals\tO\n...\tO\n\nRavanelli\tB-PER\naggravated\tO\na\tO\nfoot\tO\ninjury\tO\nin\tO\nthe\tO\n1-0\tO\ndefeat\tO\nat\tO\nChelsea\tB-ORG\non\tO\nWednesday\tO\nand\tO\nwas\tO\ngiven\tO\nonly\tO\nan\tO\neven\tO\nchance\tO\nof\tO\nplaying\tO\nat\tO\nNottingham\tB-LOC\nForest\tI-LOC\non\tO\nSaturday\tO\nby\tO\nhis\tO\nmanager\tO\nBryan\tB-PER\nRobson\tI-PER\n.\tO\n\nTENNIS\tO\n-\tO\nAUSTRALIANS\tB-MISC\nADVANCE\tO\nAT\tO\nCANADIAN\tB-MISC\nOPEN\tI-MISC\n.\tO\n\nIt\tO\nwas\tO\nAustralia\tB-MISC\nDay\tI-MISC\nat\tO\nthe\tO\n$\tO\n2\tO\nmillion\tO\nCanadian\tB-MISC\nOpen\tI-MISC\non\tO\nThursday\tO\nas\tO\nthree\tO\nAussies\tB-MISC\nreached\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nstraight-set\tO\nvictories\tO\n.\tO\n\nUnseeded\tO\nPatrick\tB-PER\nRafter\tI-PER\nrecorded\tO\nthe\tO\nmost\tO\nnoteworthy\tO\nresult\tO\nas\tO\nhe\tO\nupset\tO\nsixth-seeded\tO\nAmerican\tB-MISC\nMaliVai\tB-PER\nWashington\tI-PER\n6-2\tO\n6-1\tO\nin\tO\njust\tO\n50\tO\nminutes\tO\n.\tO\n\nTodd\tB-PER\nWoodbridge\tI-PER\n,\tO\nwho\tO\ndefeated\tO\nCanadian\tB-MISC\nDaniel\tB-PER\nNestor\tI-PER\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n,\tO\nand\tO\nMark\tB-PER\nPhilippoussis\tI-PER\n,\tO\na\tO\n6-3\tO\n6-4\tO\nwinner\tO\nover\tO\nBohdan\tB-PER\nUlihrach\tI-PER\nof\tO\nthe\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n,\tO\nalso\tO\nadvanced\tO\nand\tO\nwill\tO\nmeet\tO\nin\tO\nFriday\tO\n's\tO\nquarter-finals\tO\n.\tO\n\nThird-seeded\tO\nWayne\tB-PER\nFerreira\tI-PER\nof\tO\nSouth\tB-LOC\nAfrica\tI-LOC\ndefeated\tO\nTim\tB-PER\nHenman\tI-PER\nof\tO\nBritain\tB-LOC\n6-4\tO\n6-4\tO\nafter\tO\na\tO\nthree-hour\tO\nevening\tO\nrain\tO\ndelay\tO\nand\tO\nfifth-seeded\tO\nThomas\tB-PER\nEnqvist\tI-PER\nof\tO\nSweden\tB-LOC\nwon\tO\nhis\tO\nthird-round\tO\nmatch\tO\n,\tO\neliminating\tO\nPetr\tB-PER\nKorda\tI-PER\nof\tO\nthe\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n6-3\tO\n6-4\tO\n.\tO\n\nFerreira\tB-PER\nand\tO\nEnqvist\tB-PER\nplay\tO\nin\tO\na\tO\nFriday\tO\nnight\tO\nquarter-final\tO\n.\tO\n\nTwo\tO\nAmericans\tB-MISC\n,\tO\nseventh\tO\nseed\tO\nTodd\tB-PER\nMartin\tI-PER\nand\tO\nunseeded\tO\nAlex\tB-PER\nO'Brien\tI-PER\n,\tO\nwill\tO\nmeet\tO\non\tO\nFriday\tO\nafter\tO\nwinning\tO\nmatches\tO\non\tO\nThursday\tO\n.\tO\n\nMartin\tB-PER\novercame\tO\nCedric\tB-PER\nPioline\tI-PER\nof\tO\nFrance\tB-LOC\n2-6\tO\n6-2\tO\n6-4\tO\nand\tO\nO'Brien\tB-PER\nbeat\tO\nMikael\tB-PER\nTillstrom\tI-PER\nof\tO\nSweden\tB-LOC\n6-3\tO\n2-6\tO\n6-3\tO\n.\tO\n\n\"\tO\nIf\tO\nyou\tO\nreally\tO\nlook\tO\nat\tO\nthe\tO\nmatch\tO\n,\tO\n\"\tO\nsaid\tO\nthe\tO\n12th-ranked\tO\nWashington\tB-PER\nafter\tO\nlosing\tO\nto\tO\nthe\tO\n70th-ranked\tO\nRafter\tB-PER\n,\tO\n\"\tO\nI\tO\nnever\tO\nreally\tO\ngot\tO\na\tO\nchance\tO\nto\tO\nplay\tO\nbecause\tO\nhe\tO\nwas\tO\nserving\tO\nbig\tO\nand\tO\ngetting\tO\nin\tO\nclose\tO\nto\tO\nthe\tO\nnet\tO\n.\tO\n\nRafter\tB-PER\nmissed\tO\n10\tO\nweeks\tO\nafter\tO\nwrist\tO\nsurgery\tO\nearlier\tO\nthis\tO\nyear\tO\nand\tO\nthe\tO\ntime\tO\naway\tO\nfrom\tO\ntennis\tO\nhas\tO\ngiven\tO\nhim\tO\na\tO\nnew\tO\nperspective\tO\n.\tO\n\n\"\tO\nBefore\tO\nwhen\tO\nI\tO\nwas\tO\non\tO\ntour\tO\n,\tO\nI\tO\nalways\tO\nfelt\tO\nI\tO\nhad\tO\nto\tO\nbe\tO\nin\tO\nbed\tO\nby\tO\n9:30\tO\nor\tO\n10\tO\no'clock\tO\nand\tO\nI\tO\nhad\tO\nto\tO\nbe\tO\nup\tO\nat\tO\na\tO\ncertain\tO\ntime\tO\n,\tO\n\"\tO\nRafter\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\nMartin\tB-PER\nwas\tO\npleased\tO\nwith\tO\nhis\tO\nvictory\tO\nover\tO\nPioline\tB-PER\n,\tO\nhis\tO\nfirst\tO\nin\tO\nfive\tO\nmeetings\tO\nwith\tO\nthe\tO\n11th-ranked\tO\nFrenchman\tB-MISC\n.\tO\n\"\tO\n\n\"\tO\nI\tO\ngot\tO\nmore\tO\naggressive\tO\nin\tO\nthe\tO\nsecond\tO\nand\tO\nthird\tO\nsets\tO\nand\tO\nthe\tO\nwind\tO\npicked\tO\nup\tO\nand\tO\nthat\tO\nalso\tO\naffected\tO\nthings\tO\nbecause\tO\nCedric\tB-PER\ndefinitely\tO\nwent\tO\noff\tO\na\tO\nlittle\tO\nbit\tO\n.\tO\n\"\tO\n\nThe\tO\n26-year-old\tO\nO'Brien\tB-PER\n,\tO\nwho\tO\nwon\tO\nthe\tO\nATP\tB-MISC\nTour\tI-MISC\nstop\tO\nin\tO\nNew\tB-LOC\nHaven\tI-LOC\nlast\tO\nweek\tO\n,\tO\nhas\tO\nnow\tO\nwon\tO\n18\tO\nof\tO\nhis\tO\nlast\tO\n20\tO\nmatches\tO\n,\tO\ndating\tO\nback\tO\nto\tO\nqualifying\tO\nrounds\tO\nin\tO\nLos\tB-LOC\nAngeles\tI-LOC\nin\tO\nlate\tO\nJuly\tO\n.\tO\n\n\"\tO\nI\tO\nfeel\tO\nI\tO\n'm\tO\nhitting\tO\nthe\tO\nball\tO\nwell\tO\neven\tO\nthough\tO\nI\tO\n'm\tO\nhaving\tO\nmore\tO\nmental\tO\nletdowns\tO\nthan\tO\nI\tO\ndid\tO\nlast\tO\nweek\tO\n,\tO\n\"\tO\nO'Brien\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\n\"\tO\nI\tO\ngot\tO\na\tO\nlot\tO\nof\tO\nfirst\tO\nserves\tO\nin\tO\n,\tO\n\"\tO\nsaid\tO\nEnqvist\tB-PER\nabout\tO\nhis\tO\nvictory\tO\nover\tO\nKorda\tB-PER\n.\tO\n\"\tO\n\nStill\tO\nmarvelling\tO\nat\tO\nan\tO\nexciting\tO\n64-stroke\tO\nrally\tO\nhe\tO\nwon\tO\nin\tO\nthe\tO\nlast\tO\ngame\tO\nof\tO\nhis\tO\nsecond-round\tO\nmatch\tO\nagainst\tO\nJavier\tB-PER\nSanchez\tI-PER\nof\tO\nSpain\tB-LOC\non\tO\nTuesday\tO\n,\tO\nEnqvist\tB-PER\njoked\tO\n,\tO\n\"\tO\nToday\tO\nagainst\tO\nPetr\tB-PER\nthere\tO\nwere\tO\nabout\tO\n64\tO\nstrokes\tO\nin\tO\nthe\tO\nwhole\tO\nmatch\tO\n.\tO\n\n3\tO\n-\tO\nWayne\tB-PER\nFerreira\tI-PER\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\nbeat\tO\nTim\tB-PER\nHenman\tI-PER\n(\tO\nBritain\tO\n)\tO\n6-4\tO\n\n4\tO\n-\tO\nMarcelo\tB-PER\nRios\tI-PER\n(\tO\nChile\tB-LOC\n)\tO\nbeat\tO\nDaniel\tB-PER\nVacek\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n6-4\tO\n\n5\tO\n-\tO\nThomas\tB-PER\nEnqvist\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\nbeat\tO\nPetr\tB-PER\nKorda\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n\nPatrick\tO\nRafter\tO\n(\tO\nAustralia\tB-LOC\n)\tO\nbeat\tO\n6\tO\n-\tO\nMaliVai\tB-PER\nWashington\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n\n7\tO\n-\tO\nTodd\tB-PER\nMartin\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tO\n9\tO\n-\tO\nCedric\tB-PER\nPioline\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\n2-6\tO\n6-2\tO\n\nMark\tB-PER\nPhilippoussis\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\nbeat\tO\nBohdan\tB-PER\nUlihrach\tI-PER\n(\tO\nCzech\tB-LOC\n\nAlex\tB-PER\nO'Brien\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tO\nMikael\tB-PER\nTillstrom\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\n6-3\tO\n2-6\tO\n\nTodd\tB-PER\nWoodbridge\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\nbeat\tO\nDaniel\tB-PER\nNestor\tI-PER\n(\tO\nCanada\tB-LOC\n)\tO\n7-6\tO\n\nRUGBY\tB-ORG\nUNION\tI-ORG\n-\tO\nMULDER\tB-PER\nOUT\tO\nOF\tO\nSECOND\tO\nTEST\tO\n.\tO\n\nCentre\tO\nJapie\tB-PER\nMulder\tI-PER\nhas\tO\nbeen\tO\nruled\tO\nout\tO\nof\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n's\tO\nteam\tO\nfor\tO\nthe\tO\nsecond\tO\ntest\tO\nagainst\tO\nNew\tB-LOC\nZealand\tI-LOC\nin\tO\nPretoria\tO\non\tO\nSaturday\tO\n.\tO\n\nMulder\tB-PER\nmissed\tO\nthe\tO\nfirst\tO\ntest\tO\nin\tO\nDurban\tB-LOC\nwith\tO\nback\tO\nspasms\tO\nand\tO\nfailed\tO\na\tO\nfitness\tO\ncheck\tO\non\tO\nThursday\tO\n.\tO\n\nBut\tO\nnew\tO\nSpringbok\tB-ORG\nskipper\tO\nGary\tB-PER\nTeichmann\tI-PER\nhas\tO\nrecovered\tO\nfrom\tO\na\tO\nbruised\tO\nthigh\tO\nand\tO\nis\tO\nready\tO\nto\tO\nplay\tO\n,\tO\ncoach\tO\nAndre\tB-PER\nMarkgraaff\tI-PER\nsaid\tO\n.\tO\n\nMulder\tB-PER\n's\tO\nabsence\tO\nmeans\tO\nthat\tO\nNorthern\tB-ORG\nTransvaal\tI-ORG\ncentre\tO\nAndre\tB-PER\nSnyman\tI-PER\nshould\tO\nwin\tO\nhis\tO\nsecond\tO\ncap\tO\nalongside\tO\nprovincial\tO\ncolleague\tO\nDanie\tB-PER\nvan\tI-PER\nSchalkwyk\tI-PER\n.\tO\n\nWing\tO\nPieter\tB-PER\nHendriks\tI-PER\nis\tO\nexpected\tO\nto\tO\nretain\tO\nhis\tO\nplace\tO\n,\tO\nfollowing\tO\nspeculation\tO\nthat\tO\nSnyman\tB-PER\nwould\tO\nbe\tO\npicked\tO\nout\tO\nof\tO\nposition\tO\non\tO\nthe\tO\nwing\tO\n.\tO\n\nThe\tO\nline-up\tO\nwould\tO\nnot\tO\nbe\tO\nannounced\tO\nuntil\tO\nshortly\tO\nbefore\tO\nthe\tO\nstart\tO\n,\tO\nMarkgraaff\tB-PER\nsaid\tO\n.\tO\n\nBADMINTON\tO\n-\tO\nMALAYSIAN\tB-MISC\nOPEN\tI-MISC\nBADMINTON\tO\nRESULTS\tO\n.\tO\n\n2\tO\n-\tO\nOng\tB-PER\nEwe\tI-PER\nHock\tI-PER\n(\tO\nMalaysia\tB-LOC\n)\tO\nbeat\tO\n5/8\tO\n-\tO\nHu\tB-PER\nZhilan\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\n15-2\tO\n15-10\tO\n\n9/16\tO\n-\tO\nLuo\tB-PER\nYigang\tI-PER\n(\tO\nChina\tO\n)\tO\nbeat\tO\nJason\tB-PER\nWong\tI-PER\n(\tO\nMalaysia\tB-LOC\n)\tO\n15-5\tO\n15-6\tO\n\nIjaya\tB-PER\nIndra\tI-PER\n(\tO\nIndonesia\tB-LOC\n)\tO\nbeat\tO\nP.\tB-PER\nKantharoopan\tI-PER\n(\tO\nMalaysia\tB-LOC\n)\tO\n15-6\tO\n5-4\tO\n\n9/16\tO\n-\tO\nChen\tB-PER\nGang\tI-PER\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\n9/16\tO\n-\tO\nHermawan\tB-PER\nSusanto\tI-PER\n(\tO\nIndonesia\tB-LOC\n)\tO\n\nTENNIS\tO\n-\tO\nINJURED\tO\nCHANDA\tB-PER\nRUBIN\tI-PER\nOUT\tO\nOF\tO\nU.S.\tB-MISC\nOPEN\tI-MISC\n.\tO\n\nPromising\tO\n10th-ranked\tO\nAmerican\tB-MISC\nChanda\tB-PER\nRubin\tI-PER\nhas\tO\npulled\tO\nout\tO\nof\tO\nthe\tO\nU.S.\tB-MISC\nOpen\tI-MISC\nTennis\tI-MISC\nChampionships\tI-MISC\nwith\tO\na\tO\nwrist\tO\ninjury\tO\n,\tO\ntournament\tO\nofficials\tO\nannounced\tO\n.\tO\n\nThe\tO\n20-year-old\tO\nRubin\tB-PER\n,\tO\nwho\tO\nwas\tO\nto\tO\nbe\tO\nseeded\tO\n11th\tO\n,\tO\nis\tO\nstill\tO\nsuffering\tO\nfrom\tO\ntendinitis\tO\nof\tO\nthe\tO\nright\tO\nwrist\tO\nthat\tO\nhas\tO\nkept\tO\nher\tO\nsidelined\tO\nin\tO\nrecent\tO\nmonths\tO\n.\tO\n\nRubin\tB-PER\n's\tO\nmisfortune\tO\nturned\tO\ninto\tO\na\tO\nvery\tO\nlucky\tO\nbreak\tO\nfor\tO\neighth-seeded\tO\nOlympic\tB-MISC\nchampion\tO\nLindsay\tB-PER\nDavenport\tI-PER\n.\tO\n\nDavenport\tB-PER\nhad\tO\ndrawn\tO\none\tO\nof\tO\nthe\tO\ntoughest\tO\nfirst-round\tO\nassignments\tO\nof\tO\nany\tO\nof\tO\nthe\tO\nseeded\tO\nplayers\tO\nin\tO\n17th-ranked\tO\nKarina\tB-PER\nHabsudova\tI-PER\nof\tO\nSlovakia\tB-LOC\n.\tO\n\nBut\tO\nas\tO\nthe\tO\nhighest-ranked\tO\nnon-seeded\tO\nplayer\tO\nin\tO\nthe\tO\ntournament\tO\n,\tO\nHabsudova\tB-PER\nwill\tO\nbe\tO\nmoved\tO\ninto\tO\nRubin\tB-PER\n's\tO\nslot\tO\nin\tO\nthe\tO\ndraw\tO\n,\tO\nwhile\tO\nDavenport\tB-PER\nwill\tO\nnow\tO\nget\tO\na\tO\nqualifier\tO\nin\tO\nthe\tO\nfirst\tO\nround\tO\n,\tO\naccording\tO\nto\tO\nU.S.\tB-MISC\nTennis\tI-MISC\nAssociation\tI-MISC\nofficials\tO\n.\tO\n\nRubin\tB-PER\nis\tO\nthe\tO\nthird\tO\nnotable\tO\nwithdrawal\tO\nfrom\tO\nthe\tO\nwomen\tO\n's\tO\ncompetition\tO\nafter\tO\n12th-ranked\tO\nformer\tO\nAustralian\tB-MISC\nOpen\tI-MISC\nchampion\tO\nMary\tB-PER\nPierce\tI-PER\nand\tO\n20th-ranked\tO\nWimbledon\tB-MISC\nsemifinalist\tO\nMeredith\tB-PER\nMcGrath\tI-PER\npulled\tO\nout\tO\nearlier\tO\nthis\tO\nweek\tO\nwith\tO\ninjuries\tO\n.\tO\n\nMen\tO\n's\tO\nAustralian\tB-MISC\nOpen\tI-MISC\nchampion\tO\nBoris\tB-PER\nBecker\tI-PER\nwill\tO\nalso\tO\nmiss\tO\nthe\tO\nyear\tO\n's\tO\nfinal\tO\nGrand\tB-MISC\nSlam\tI-MISC\nwith\tO\na\tO\nwrist\tO\ninjury\tO\n.\tO\n\nBASEBALL\tO\n-\tO\nMAJOR\tB-MISC\nLEAGUE\tI-MISC\nSTANDINGS\tO\nAFTER\tO\nTHURSDAY\tO\n'S\tO\nGAMES\tO\n.\tO\n\nTORONTO\tB-ORG\n59\tO\n69\tO\n.461\tO\n14\tO\n\nDETROIT\tB-ORG\n45\tO\n82\tO\n.354\tO\n27\tO\n1/2\tO\n\nMINNESOTA\tB-ORG\n63\tO\n64\tO\n.496\tO\n13\tO\n\nTEXAS\tB-ORG\n74\tO\n54\tO\n.578\tO\n-\tO\n\nCALIFORNIA\tB-ORG\n59\tO\n68\tO\n.465\tO\n14\tO\n1/2\tO\n\nSEATTLE\tB-ORG\nAT\tO\nBOSTON\tB-LOC\n\nMILWAUKEE\tB-ORG\nAT\tO\nCLEVELAND\tB-LOC\n\nCALIFORNIA\tB-ORG\nAT\tO\nBALTIMORE\tB-LOC\n\nOAKLAND\tB-ORG\nAT\tO\nNEW\tB-LOC\nYORK\tI-LOC\n\nMONTREAL\tB-ORG\n68\tO\n58\tO\n.540\tO\n11\tO\n\nFLORIDA\tB-ORG\n58\tO\n69\tO\n.457\tO\n21\tO\n1/2\tO\n\nLOS\tB-ORG\nANGELES\tI-ORG\n67\tO\n60\tO\n.528\tO\n2\tO\n\nCOLORADO\tB-ORG\n66\tO\n62\tO\n.516\tO\n3\tO\n1/2\tO\n\nCINCINNATI\tB-ORG\nAT\tO\nFLORIDA\tB-LOC\n(\tO\ndoubleheader\tO\n)\tO\n\nCHICAGO\tB-ORG\nAT\tO\nATLANTA\tB-LOC\n\nST\tB-ORG\nLOUIS\tI-ORG\nAT\tO\nHOUSTON\tB-LOC\n\nPITTSBURGH\tO\nAT\tO\nCOLORADO\tB-LOC\n\nNEW\tB-ORG\nYORK\tI-ORG\nAT\tO\nLOS\tB-LOC\nANGELES\tI-LOC\n\nPHILADELPHIA\tB-ORG\nAT\tO\nSAN\tB-LOC\nDIEGO\tI-LOC\n\nBASEBALL\tO\n-\tO\nMAJOR\tB-MISC\nLEAGUE\tI-MISC\nRESULTS\tO\nTHURSDAY\tO\n.\tO\n\nBOSTON\tB-ORG\n2\tO\nOakland\tB-ORG\n1\tO\n\nSeattle\tB-ORG\n10\tO\nBALTIMORE\tB-ORG\n3\tO\n\nToronto\tB-ORG\n1\tO\nCHICAGO\tB-ORG\n0\tO\n(\tO\nin\tO\n6\tO\n1/2\tO\n)\tO\n\nDetroit\tB-ORG\n10\tO\nKANSAS\tB-ORG\nCITY\tI-ORG\n3\tO\n\nTexas\tB-ORG\n11\tO\nMINNESOTA\tB-ORG\n2\tO\n\nCOLORADO\tB-ORG\n10\tO\nSt\tB-ORG\nLouis\tI-ORG\n5\tO\n\nCincinnati\tB-ORG\n3\tO\nATLANTA\tB-ORG\n2\tO\n(\tO\nin\tO\n13\tO\n)\tO\n\nPittsburgh\tB-ORG\n8\tO\nHOUSTON\tO\n6\tO\n\nLOS\tB-ORG\nANGELES\tI-ORG\n8\tO\nPhiladelphia\tB-ORG\n5\tO\n\nMontreal\tB-ORG\n5\tO\nSAN\tB-ORG\nFRANCISCO\tI-ORG\n4\tO\n\nBASEBALL\tO\n-\tO\nSORRENTO\tB-PER\nHITS\tO\nSLAM\tO\nAS\tO\nSEATTLE\tB-ORG\nROUTS\tO\nORIOLES\tB-ORG\n.\tO\n\nFormer\tO\nOriole\tB-MISC\nJamie\tB-PER\nMoyer\tI-PER\nallowed\tO\ntwo\tO\nhits\tO\nover\tO\neight\tO\nscoreless\tO\ninnings\tO\nbefore\tO\ntiring\tO\nin\tO\nthe\tO\nninth\tO\nand\tO\nPaul\tB-PER\nSorrento\tI-PER\nadded\tO\nhis\tO\nthird\tO\ngrand\tO\nslam\tO\nof\tO\nthe\tO\nseason\tO\nas\tO\nthe\tO\nSeattle\tB-ORG\nMariners\tI-ORG\nrouted\tO\nBaltimore\tB-ORG\n10-3\tO\nThursday\tO\n.\tO\n\nMoyer\tB-PER\n(\tO\n10-2\tO\n)\tO\n,\tO\nwho\tO\nwas\tO\ntagged\tO\nfor\tO\na\tO\npair\tO\nof\tO\nhomers\tO\nby\tO\nMike\tB-PER\nDevereaux\tI-PER\nand\tO\nBrady\tB-PER\nAnderson\tI-PER\nand\tO\nthree\tO\nruns\tO\nin\tO\nthe\tO\nninth\tO\n,\tO\nwalked\tO\nnone\tO\nand\tO\nstruck\tO\nout\tO\ntwo\tO\n.\tO\n\nNorm\tB-PER\nCharlton\tI-PER\nretired\tO\nthe\tO\nfinal\tO\nthree\tO\nbatters\tO\nto\tO\nseal\tO\nthe\tO\nvictory\tO\n.\tO\n\nWith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nfifth\tO\nKen\tB-PER\nGriffey\tI-PER\nJr\tI-PER\nand\tO\nEdgar\tB-PER\nMartinez\tI-PER\nstroked\tO\nback-to-back\tO\nsingles\tO\noff\tO\nOrioles\tB-ORG\nstarter\tO\nRocky\tB-PER\nCoppinger\tI-PER\n(\tO\n7-5\tO\n)\tO\nand\tO\nJay\tB-PER\nBuhner\tI-PER\nwalked\tO\n.\tO\n\nSorrento\tB-PER\nfollowed\tO\nby\tO\nhitting\tO\na\tO\n1-2\tO\npitch\tO\njust\tO\nover\tO\nthe\tO\nright-field\tO\nwall\tO\nfor\tO\na\tO\n7-0\tO\nadvantage\tO\n.\tO\n\nRight\tO\nfielder\tO\nBobby\tB-PER\nBonilla\tI-PER\nwas\tO\nafter\tO\nthe\tO\nball\tO\n,\tO\nwhich\tO\nwas\tO\ntouched\tO\nby\tO\nfans\tO\nat\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nscoreboard\tO\nin\tO\nright\tO\n.\tO\n\n\"\tO\nThings\tO\nfell\tO\nin\tO\nfor\tO\nus\tO\n,\tO\n\"\tO\nsaid\tO\nSorrento\tB-PER\n,\tO\nwho\tO\nhas\tO\nsix\tO\ncareer\tO\ngrand\tO\nslams\tO\nand\tO\nhit\tO\nthe\tO\nninth\tO\nof\tO\nthe\tO\nseason\tO\nfor\tO\nthe\tO\nMariners\tB-ORG\n.\tO\n\nIn\tO\nthe\tO\nAmerican\tB-MISC\nLeague\tI-MISC\nwild-card\tO\nrace\tO\n,\tO\nthe\tO\nMariners\tB-ORG\nare\tO\nthree\tO\ngames\tO\nbehind\tO\nthe\tO\nWhite\tB-ORG\nSox\tI-ORG\n,\tO\ntwo\tO\nbehind\tO\nBaltimore\tB-ORG\nand\tO\ntwo\tO\nahead\tO\nof\tO\nthe\tO\nRed\tB-ORG\nSox\tI-ORG\nheading\tO\ninto\tO\nBoston\tB-LOC\nfor\tO\na\tO\nweekend\tO\nseries\tO\n.\tO\n\nMoyer\tB-PER\nretired\tO\n11\tO\nstraight\tO\nbatters\tO\nbetween\tO\nthe\tO\nthird\tO\nand\tO\nseventh\tO\ninnings\tO\nand\tO\nthrew\tO\ntwo\tO\nor\tO\nfewer\tO\npitches\tO\nto\tO\n11\tO\nof\tO\nthe\tO\n29\tO\nbatters\tO\nhe\tO\nfaced\tO\n.\tO\n\nWe\tO\nwon\tO\nthe\tO\ngame\tO\n,\tO\n\"\tO\nsaid\tO\nMoyer\tB-PER\n.\tO\n\nCoppinger\tB-PER\n(\tO\n7-5\tO\n)\tO\nwas\tO\ntagged\tO\nfor\tO\neight\tO\nruns\tO\nand\tO\n10\tO\nhits\tO\nin\tO\n4\tO\n1/3\tO\ninnings\tO\n.\tO\n\nOrioles\tB-ORG\nmanager\tO\nDavey\tB-PER\nJohnson\tI-PER\nmissed\tO\nthe\tO\ngame\tO\nafter\tO\nbeing\tO\nadmitted\tO\nto\tO\na\tO\nhospital\tO\nwith\tO\nan\tO\nirregular\tO\nheartbeat\tO\n.\tO\n\nBench\tO\ncoach\tO\nAndy\tB-PER\nEtchebarren\tI-PER\ntook\tO\nhis\tO\nplace\tO\n.\tO\n\nIn\tO\nBoston\tB-LOC\n,\tO\nTroy\tB-PER\nO'Leary\tI-PER\nhomered\tO\noff\tO\nthe\tO\nright-field\tO\nfoul\tO\npole\tO\nwith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\nninth\tO\nand\tO\nthe\tO\nRed\tB-ORG\nSox\tI-ORG\nclimbed\tO\nto\tO\nthe\tO\n.500\tO\nmark\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nthis\tO\nseason\tO\nwith\tO\ntheir\tO\nfourth\tO\nstraight\tO\nvictory\tO\n,\tO\n2-1\tO\nover\tO\nthe\tO\nOakland\tB-ORG\nAthletics\tI-ORG\n.\tO\n\nBoston\tB-ORG\nhas\tO\nwon\tO\n15\tO\nof\tO\nits\tO\nlast\tO\n19\tO\ngames\tO\n.\tO\n\nBoston\tB-ORG\n's\tO\nRoger\tB-PER\nClemens\tI-PER\n(\tO\n7-11\tO\n)\tO\nwas\tO\none\tO\nout\tO\naway\tO\nfrom\tO\nhis\tO\nsecond\tO\nstraight\tO\nshutout\tO\nwhen\tO\npinch-hitter\tO\nMatt\tB-PER\nStairs\tI-PER\ntripled\tO\nover\tO\nthe\tO\nhead\tO\nof\tO\ncentre\tO\nfielder\tO\nLee\tB-PER\nTinsley\tI-PER\non\tO\nan\tO\n0-2\tO\npitch\tO\nand\tO\npinch-hitter\tO\nTerry\tB-PER\nSteinbach\tI-PER\ndunked\tO\na\tO\nbroken-bat\tO\nsingle\tO\ninto\tO\nright\tO\nto\tO\nlift\tO\nOakland\tB-ORG\ninto\tO\na\tO\n1-1\tO\ntie\tO\n.\tO\n\nThe\tO\nrun\tO\nbroke\tO\nClemens\tB-PER\n'\tO\n28-inning\tO\nshutout\tO\nstreak\tO\n,\tO\nlongest\tO\nin\tO\nthe\tO\nmajors\tO\nthis\tO\nseason\tO\n.\tO\n\nReliever\tO\nMark\tB-PER\nAcre\tI-PER\n(\tO\n0-1\tO\n)\tO\ntook\tO\nthe\tO\nloss\tO\n.\tO\n\nIn\tO\nNew\tB-LOC\nYork\tI-LOC\n,\tO\nGarret\tB-PER\nAnderson\tI-PER\nand\tO\nGary\tB-PER\nDiSarcina\tI-PER\ndrove\tO\nin\tO\ntwo\tO\nruns\tO\napiece\tO\nin\tO\na\tO\nfive-run\tO\nfirst\tO\ninning\tO\nand\tO\nJim\tB-PER\nEdmonds\tI-PER\nhighlighted\tO\na\tO\nsix-run\tO\nsixth\tO\nwith\tO\na\tO\nbases-loaded\tO\ndouble\tO\nas\tO\nthe\tO\nCalifornia\tB-ORG\nAngels\tI-ORG\ncoasted\tO\nto\tO\na\tO\n12-3\tO\nvictory\tO\nover\tO\nthe\tO\nYankees\tB-ORG\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\ntheir\tO\nthree-game\tO\nseries\tO\n.\tO\n\nThe\tO\nAngels\tB-ORG\nbattered\tO\nKenny\tB-PER\nRogers\tI-PER\n(\tO\n10-7\tO\n)\tO\nfor\tO\nfive\tO\nruns\tO\nin\tO\nthe\tO\nfirst\tO\n.\tO\n\nThe\tO\nYankees\tB-ORG\nhave\tO\nallowed\tO\nat\tO\nleast\tO\ntwo\tO\nruns\tO\nin\tO\nthe\tO\nfirst\tO\ninning\tO\nin\tO\nsix\tO\nstraight\tO\ngames\tO\n,\tO\ngetting\tO\noutscored\tO\n21-1\tO\nin\tO\nthe\tO\nfirst\tO\ninning\tO\nin\tO\nthat\tO\nspan\tO\n.\tO\n\nChuck\tB-PER\nFinley\tI-PER\n(\tO\n12-12\tO\n)\tO\nsnapped\tO\na\tO\nfour-game\tO\nlosing\tO\nstreak\tO\n.\tO\n\nIn\tO\nKansas\tB-LOC\nCity\tI-LOC\n,\tO\nTravis\tB-PER\nFryman\tI-PER\ndoubled\tO\nin\tO\nthe\tO\ngo-ahead\tO\nrun\tO\nin\tO\nthe\tO\nfifth\tO\nand\tO\nMelvin\tB-PER\nNieves\tI-PER\nand\tO\nDamion\tB-PER\nEasley\tI-PER\nbelted\tO\ntwo-run\tO\nhomers\tO\nas\tO\nthe\tO\nDetroit\tB-ORG\nTigers\tI-ORG\nclaimed\tO\na\tO\n10-3\tO\nwin\tO\nover\tO\nthe\tO\nRoyals\tB-ORG\n,\tO\nhanding\tO\nthem\tO\ntheir\tO\nfifth\tO\nstraight\tO\nloss\tO\n.\tO\n\nThe\tO\nTigers\tB-ORG\nwon\tO\ntheir\tO\nthird\tO\nstraight\tO\nand\tO\nhalted\tO\na\tO\nseven-game\tO\nroad\tO\nlosing\tO\nstreak\tO\nbehind\tO\nJustin\tB-PER\nThompson\tI-PER\n(\tO\n1-2\tO\n)\tO\n,\tO\nwho\tO\nearned\tO\nhis\tO\nfirst\tO\nmajor-league\tO\nwin\tO\n.\tO\n\nTim\tB-PER\nBelcher\tI-PER\n(\tO\n12-8\tO\n)\tO\nwas\tO\ntagged\tO\nfor\tO\nsix\tO\nruns\tO\nand\tO\nnine\tO\nhits\tO\nin\tO\neight\tO\ninnings\tO\n.\tO\n\nAt\tO\nMinnesota\tB-LOC\n,\tO\nKen\tB-PER\nHill\tI-PER\nallowed\tO\ntwo\tO\nruns\tO\nen\tO\nroute\tO\nto\tO\nhis\tO\nsixth\tO\ncomplete\tO\ngame\tO\nof\tO\nthe\tO\nseason\tO\nand\tO\nRusty\tB-PER\nGreer\tI-PER\nadded\tO\nthree\tO\nhits\tO\n,\tO\nincluding\tO\na\tO\nhomer\tO\n,\tO\nand\tO\ntwo\tO\nRBI\tB-MISC\nas\tO\nthe\tO\nred-hot\tO\nTexas\tB-ORG\nRangers\tI-ORG\nrouted\tO\nthe\tO\nTwins\tB-ORG\n11-2\tO\n.\tO\n\nThe\tO\nRangers\tB-ORG\n,\tO\nwho\tO\nwon\tO\nfor\tO\nthe\tO\n11th\tO\ntime\tO\nin\tO\ntheir\tO\nlast\tO\n13\tO\ngames\tO\n,\tO\nhave\tO\nscored\tO\n45\tO\nruns\tO\nin\tO\ntheir\tO\nlast\tO\nfive\tO\ncontests\tO\n.\tO\n\nHill\tB-PER\n(\tO\n14-7\tO\n)\tO\nallowed\tO\n10\tO\nhits\tO\n.\tO\n\nIn\tO\nChicago\tB-LOC\n,\tO\nErik\tB-PER\nHanson\tI-PER\noutdueled\tO\nAlex\tB-PER\nFernandez\tI-PER\n,\tO\nand\tO\nJacob\tB-PER\nBrumfield\tI-PER\ndrove\tO\nin\tO\nOtis\tB-PER\nNixon\tI-PER\nwith\tO\nthe\tO\ngame\tO\n's\tO\nonly\tO\nrun\tO\nin\tO\nthe\tO\nsixth\tO\ninning\tO\nas\tO\nthe\tO\nToronto\tB-ORG\nBlue\tI-ORG\nJays\tI-ORG\nblanked\tO\nthe\tO\nWhite\tB-ORG\nSox\tI-ORG\n1-0\tO\nin\tO\na\tO\ngame\tO\nshortened\tO\nto\tO\nsix\tO\ninnings\tO\ndue\tO\nto\tO\nrain\tO\n.\tO\n\nToronto\tB-ORG\nwon\tO\nits\tO\nfifth\tO\nstraight\tO\nand\tO\nhanded\tO\nthe\tO\nWhite\tB-ORG\nSox\tI-ORG\ntheir\tO\nseventh\tO\nloss\tO\nin\tO\nnine\tO\ngames\tO\n.\tO\n\nHanson\tB-PER\n(\tO\n11-15\tO\n)\tO\nallowed\tO\nthree\tO\nhits\tO\n,\tO\nwalked\tO\nthree\tO\nand\tO\nstruck\tO\nout\tO\nfour\tO\nto\tO\nsnap\tO\na\tO\npersonal\tO\nthree-game\tO\nlosing\tO\nstreak\tO\n.\tO\n\nFernandez\tB-PER\n(\tO\n12-8\tO\n)\tO\nscattered\tO\nsix\tO\nhits\tO\n.\tO\n\nSOCCER\tO\n-\tO\nSPORTING\tB-ORG\nSTART\tO\nNEW\tO\nSEASON\tO\nWITH\tO\nA\tO\nWIN\tO\n.\tO\n\nSporting\tB-ORG\n's\tO\nLuis\tB-PER\nMiguel\tI-PER\nPredrosa\tI-PER\nscored\tO\nthe\tO\nfirst\tO\ngoal\tO\nof\tO\nthe\tO\nnew\tO\nleague\tO\nseason\tO\nas\tO\nthe\tO\nLisbon\tB-LOC\nside\tO\ncruised\tO\nto\tO\na\tO\n3-1\tO\naway\tO\nwin\tO\nover\tO\nSC\tB-ORG\nEspinho\tI-ORG\non\tO\nFriday\tO\n.\tO\n\nPredrosa\tB-PER\ndrilled\tO\na\tO\nright-foot\tO\nshot\tO\ninto\tO\nthe\tO\nback\tO\nof\tO\nthe\tO\nnet\tO\nafter\tO\n24\tO\nminutes\tO\nto\tO\nset\tO\nSporting\tB-ORG\non\tO\nthe\tO\nway\tO\nto\tO\nvictory\tO\n.\tO\n\nAlthough\tO\nEspinho\tB-ORG\n's\tO\nNail\tB-PER\nBesirovic\tI-PER\nput\tO\nthe\tO\nhome\tO\nside\tO\nback\tO\non\tO\nterms\tO\nin\tO\nthe\tO\n35th\tO\nminute\tO\n,\tO\nSporting\tB-ORG\nquickly\tO\nrestored\tO\ntheir\tO\nlead\tO\n.\tO\n\nJose\tB-PER\nLuis\tI-PER\nVidigal\tI-PER\nscored\tO\nin\tO\nthe\tO\n38th\tO\nminute\tO\nand\tO\nMustapha\tB-PER\nHadji\tI-PER\nadded\tO\nthe\tO\nthird\tO\nin\tO\nthe\tO\n57th\tO\n.\tO\n\nThe\tO\ngame\tO\nwas\tO\nbrought\tO\nforward\tO\nfrom\tO\nSunday\tO\nwhen\tO\nreigning\tO\nchampions\tO\nPorto\tB-ORG\nand\tO\nLisbon\tB-ORG\nrivals\tO\nBenfica\tB-ORG\nplay\tO\ntheir\tO\nfirst\tO\ngames\tO\nof\tO\nthe\tO\nseason\tO\n.\tO\n\nSOCCER\tO\n-\tO\nPORTUGUESE\tB-MISC\nFIRST\tO\nDIVISION\tO\nRESULT\tO\n.\tO\n\nResult\tO\nof\tO\na\tO\nPortuguese\tB-MISC\nfirst\tO\n\nEspinho\tO\n1\tO\nSporting\tB-ORG\n3\tO\n\nSOCCER\tO\n-\tO\nST\tB-ORG\nPAULI\tI-ORG\nTAKE\tO\nPOINT\tO\nWITH\tO\nLATE\tO\nFIGHTBACK\tO\n.\tO\n\nHamburg\tB-LOC\nside\tO\nSt\tB-ORG\nPauli\tI-ORG\n,\tO\ntipped\tO\nas\tO\nprime\tO\ncandidates\tO\nfor\tO\nrelegation\tO\n,\tO\nproduced\tO\na\tO\nstunning\tO\nsecond-half\tO\nfightback\tO\nto\tO\ndraw\tO\n4-4\tO\nin\tO\ntheir\tO\nBundesliga\tB-MISC\nclash\tO\nwith\tO\nSchalke\tB-ORG\non\tO\nFriday\tO\n.\tO\n\nSchalke\tB-ORG\n,\tO\nwho\tO\nfinished\tO\nthird\tO\nlast\tO\nseason\tO\n,\tO\nraced\tO\nto\tO\na\tO\n3-1\tO\nlead\tO\nat\tO\nhalftime\tO\n.\tO\n\nSt\tB-ORG\nPauli\tI-ORG\npulled\tO\na\tO\ngoal\tO\nback\tO\nthrough\tO\nAndre\tB-PER\nTrulsen\tI-PER\nbut\tO\nSchalke\tB-ORG\nstriker\tO\nMartin\tB-PER\nMax\tI-PER\nrestored\tO\nhis\tO\nteam\tO\n's\tO\ntwo-goal\tO\ncushion\tO\nshortly\tO\nafterwards\tO\n.\tO\n\nChristian\tB-PER\nSpringer\tI-PER\nput\tO\nSt\tB-ORG\nPauli\tI-ORG\nback\tO\nin\tO\ntouch\tO\nin\tO\nthe\tO\n64th\tO\nminute\tO\nand\tO\nthree\tO\nminutes\tO\nlater\tO\nthey\tO\nwere\tO\nlevel\tO\n,\tO\nthanks\tO\nto\tO\na\tO\npenalty\tO\nfrom\tO\nThomas\tB-PER\nSabotzik\tI-PER\n.\tO\n\nIn\tO\nthe\tO\nnight\tO\n's\tO\nonly\tO\nother\tO\nmatch\tO\n,\tO\nHamburg\tB-ORG\nbeat\tO\nHansa\tB-ORG\nRostock\tI-ORG\n1-0\tO\n,\tO\nKarsten\tB-PER\nBaeron\tI-PER\nscoring\tO\nthe\tO\nwinner\tO\nafter\tO\nsome\tO\ndazzling\tO\nbuild-up\tO\nfrom\tO\nin-form\tO\nmidfielder\tO\nHarald\tB-PER\nSpoerl\tI-PER\n.\tO\n\nThe\tO\nwin\tO\nput\tO\nHamburg\tB-ORG\nin\tO\nsecond\tO\nplace\tO\nin\tO\nthe\tO\nGerman\tB-MISC\nfirst\tO\ndivision\tO\nafter\tO\nthree\tO\ngames\tO\n,\tO\nthough\tO\nthat\tO\nmay\tO\nchange\tO\nafter\tO\nthe\tO\nother\tO\nsides\tO\nplay\tO\non\tO\nSaturday\tO\n.\tO\n\nATHLETICS\tO\n-\tO\nSALAH\tB-PER\nHISSOU\tI-PER\nBREAKS\tO\n10,000\tO\nMETRES\tO\nWORLD\tO\nRECORD\tO\n.\tO\n\nMorocco\tB-LOC\n's\tO\nSalah\tB-PER\nHissou\tI-PER\nbroke\tO\nthe\tO\nmen\tO\n's\tO\n10,000\tO\nmetres\tO\nworld\tO\nrecord\tO\non\tO\nFriday\tO\nwhen\tO\nhe\tO\nclocked\tO\n26\tO\nminutes\tO\n38.08\tO\nseconds\tO\nat\tO\nthe\tO\nBrussels\tB-LOC\ngrand\tO\nprix\tO\non\tO\nFriday\tO\n.\tO\n\nThe\tO\nprevious\tO\nmark\tO\nof\tO\n26:43.53\tO\nwas\tO\nset\tO\nby\tO\nEthiopia\tB-LOC\n's\tO\nHaile\tB-PER\nGebreselassie\tI-PER\nin\tO\nthe\tO\nDutch\tB-MISC\ntown\tO\nof\tO\nHengelo\tB-LOC\nin\tO\nJune\tO\nlast\tO\nyear\tO\n.\tO\n\nSOCCER\tO\n-\tO\nGERMAN\tB-MISC\nFIRST\tO\nDIVISION\tO\nSUMMARIES\tO\n.\tO\n\nSummaries\tO\nof\tO\nBundesliga\tB-MISC\nmatches\tO\non\tO\nFriday\tO\n:\tO\n\nHansa\tB-ORG\nRostock\tI-ORG\n0\tO\nHamburg\tO\n1\tO\n(\tO\nBaeron\tB-PER\n64th\tO\nmin\tO\n)\tO\n.\tO\n\nSt\tB-ORG\nPauli\tI-ORG\n4\tO\n(\tO\nDriller\tB-PER\n15th\tO\n,\tO\nTrulsen\tB-PER\n54th\tO\n,\tO\nSpringer\tB-PER\n64th\tO\n,\tO\nSobotzik\tB-PER\n67th\tO\npenalty\tO\n)\tO\nSchalke\tB-ORG\n4\tO\n(\tO\nMax\tB-PER\n11th\tO\n,\tO\nThon\tB-PER\n34th\tO\n,\tO\nWilmots\tB-PER\n38th\tO\n,\tO\nSpringer\tB-PER\n64th\tO\n)\tO\n.\tO\n\nSOCCER\tO\n-\tO\nFRENCH\tB-MISC\nLEAGUE\tO\nSUMMARY\tO\n.\tO\n\nSummary\tO\nof\tO\na\tO\nFrench\tB-MISC\nfirst\tO\ndivision\tO\nmatch\tO\non\tO\nFriday\tO\n.\tO\n\nNancy\tB-ORG\n0\tO\nParis\tB-ORG\nSt\tI-ORG\nGermain\tI-ORG\n0\tO\n.\tO\n\nSOCCER\tO\n-\tO\nFRENCH\tB-MISC\nLEAGUE\tO\nRESULT\tO\n.\tO\n\nResult\tO\nof\tO\na\tO\nFrench\tB-MISC\nfirst\tO\ndivision\tO\nmatch\tO\non\tO\nFriday\tO\n.\tO\n\nNancy\tB-ORG\n0\tO\nParis\tB-ORG\nSt\tI-ORG\nGermain\tI-ORG\n0\tO\n\nSOCCER\tO\n-\tO\nGERMAN\tB-MISC\nFIRST\tO\nDIVISION\tO\nRESULTS\tO\n.\tO\n\nResults\tO\nof\tO\nGerman\tB-MISC\nfirst\tO\ndivision\tO\n\nSt\tB-ORG\nPauli\tI-ORG\n4\tO\nSchalke\tB-ORG\n4\tO\n\nHansa\tO\nRostock\tO\n0\tO\nHamburg\tB-ORG\n1\tO\n\nATHLETICS\tO\n-\tO\nMASTERKOVA\tB-PER\nBREAKS\tO\nSECOND\tO\nWORLD\tO\nRECORD\tO\nIN\tO\n10\tO\nDAYS\tO\n.\tO\n\nRussia\tB-LOC\n's\tO\ndouble\tO\nOlympic\tB-MISC\nchampion\tO\nSvetlana\tB-PER\nMasterkova\tI-PER\nsmashed\tO\nher\tO\nsecond\tO\nworld\tO\nrecord\tO\nin\tO\njust\tO\n10\tO\ndays\tO\non\tO\nFriday\tO\nwhen\tO\nshe\tO\nbettered\tO\nthe\tO\nmark\tO\nfor\tO\nthe\tO\nwomen\tO\n's\tO\n1,000\tO\nmetres\tO\n.\tO\n\nAfter\tO\nbreaking\tO\nthe\tO\nworld\tO\nrecord\tO\nfor\tO\nthe\tO\nwomen\tO\n's\tO\nmile\tO\nin\tO\nZurich\tB-LOC\nlast\tO\nWednesday\tO\n,\tO\nthe\tO\nOlympic\tB-MISC\n800\tO\nand\tO\n1,500\tO\nmetres\tO\nchampion\tO\nclocked\tO\ntwo\tO\nminutes\tO\n28.98\tO\nseconds\tO\nover\tO\n1,000\tO\nat\tO\nthe\tO\nBrussels\tB-LOC\ngrand\tO\nprix\tO\nmeeting\tO\n.\tO\n\nThe\tO\nRussian\tB-MISC\nate\tO\nup\tO\nthe\tO\nground\tO\nin\tO\na\tO\nswift\tO\nlast\tO\nlap\tO\nto\tO\nshave\tO\n0.36\tO\nseconds\tO\noff\tO\nthe\tO\nprevious\tO\nbest\tO\nof\tO\n2:29.34\tO\nset\tO\nby\tO\nMozambique\tB-LOC\n's\tO\nMaria\tB-PER\nMutola\tI-PER\nin\tO\nthe\tO\nsame\tO\nstadium\tO\nin\tO\nAugust\tO\nlast\tO\nyear\tO\n.\tO\n\nFormer\tO\nworld\tO\n800\tO\nchampion\tO\nMutola\tB-PER\npushed\tO\nMasterkova\tB-PER\nall\tO\nthe\tO\nway\tO\n,\tO\nfinishing\tO\nsecond\tO\nin\tO\n2:29.66\tO\n.\tO\n\nBut\tO\nit\tO\nwas\tO\nthe\tO\nRussian\tB-MISC\nwho\tO\npicked\tO\nup\tO\nthe\tO\nbonus\tO\nof\tO\n$\tO\n25,000\tO\nfor\tO\nthe\tO\nhistoric\tO\nrun\tO\nin\tO\nfront\tO\nof\tO\na\tO\ncapacity\tO\n40,000\tO\ncrowd\tO\n.\tO\n\nMasterkova\tB-PER\ndominated\tO\nthe\tO\nmiddle-distance\tO\nraces\tO\nat\tO\nthe\tO\nrecent\tO\nAtlanta\tB-MISC\nGames\tI-MISC\nfollowing\tO\nher\tO\nreturn\tO\nto\tO\ncompetition\tO\nthis\tO\nseason\tO\nafter\tO\na\tO\nthree-year\tO\nmaternity\tO\nbreak\tO\n.\tO\n\nIn\tO\nher\tO\nfirst\tO\nmile\tO\nrace\tO\nat\tO\nthe\tO\nrichest\tO\nmeeting\tO\nin\tO\nZurich\tB-LOC\nlast\tO\nWednesday\tO\n,\tO\nshe\tO\nslashed\tO\n3.05\tO\nseconds\tO\noff\tO\nthe\tO\nprevious\tO\nrecord\tO\n.\tO\n\nThe\tO\nrecord\tO\nof\tO\nfour\tO\nminutes\tO\n,\tO\n12.56\tO\nseconds\tO\nin\tO\nZurich\tB-LOC\nearned\tO\nMasterkova\tB-PER\na\tO\nbonus\tO\nof\tO\n$\tO\n50,000\tO\nplus\tO\none\tO\nkilo\tO\nof\tO\ngold\tO\n.\tO\n\nAfter\tO\nFriday\tO\n's\tO\nperformance\tO\nthe\tO\nRussian\tB-MISC\nwill\tO\nhave\tO\nearned\tO\nwell\tO\nover\tO\n$\tO\n100,000\tO\nin\tO\nless\tO\nthan\tO\na\tO\nfortnight\tO\n,\tO\ntaking\tO\nher\tO\nappearance\tO\nmoney\tO\ninto\tO\naccount\tO\n.\tO\n\nBrussels\tB-LOC\norganisers\tO\nhad\tO\nlaid\tO\na\tO\nnew\tO\ntrack\tO\nfor\tO\nthe\tO\nmeeting\tO\ncomparable\tO\nto\tO\nthe\tO\nsurface\tO\nat\tO\nthe\tO\nAtlanta\tB-MISC\nGames\tI-MISC\nbut\tO\nput\tO\ndown\tO\non\tO\na\tO\nsofter\tO\nsurface\tO\n.\tO\n\nMasterkova\tB-PER\nclearly\tO\nenjoyed\tO\nit\tO\n.\tO\n\nMutola\tB-PER\nlooked\tO\nthreatening\tO\nin\tO\nthe\tO\nfinal\tO\n200\tO\nmetres\tO\nbut\tO\nthe\tO\nRussian\tB-MISC\nfound\tO\nan\tO\nextra\tO\ngear\tO\nto\tO\npower\tO\nhome\tO\nseveral\tO\nstrides\tO\nahead\tO\n,\tO\npointing\tO\nat\tO\nthe\tO\ntime\tO\non\tO\nthe\tO\nclock\tO\nwith\tO\ndelight\tO\nas\tO\nshe\tO\ncrossed\tO\nthe\tO\nline\tO\n.\tO\n\n2:30.67\tO\nChristine\tB-PER\nWachtel\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\nBerlin\tB-LOC\n17.8.90\tO\n\n2:29.34\tO\nMaria\tB-PER\nMutola\tI-PER\n(\tO\nMozambique\tB-LOC\n)\tO\nBrussels\tB-LOC\n25.8.95\tO\n\n2:28.98\tO\nSvetlana\tB-PER\nMasterkova\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\nBrussels\tB-LOC\n23.8.96\tO\n\nATHLETICS\tO\n-\tO\nMASTERKOVA\tB-PER\nBREAKS\tO\nWOMEN\tO\n'S\tO\nWORLD\tO\n1,000\tO\nRECORD\tO\n.\tO\n\nRussian\tB-MISC\nSvetlana\tB-PER\nMasterkova\tI-PER\nbroke\tO\nthe\tO\nwomen\tO\n's\tO\nworld\tO\n1,000\tO\nmetres\tO\nrecord\tO\non\tO\nFriday\tO\nwhen\tO\nshe\tO\nclocked\tO\nan\tO\nunofficial\tO\ntwo\tO\nminutes\tO\n28.99\tO\nseconds\tO\nat\tO\nthe\tO\nBrussels\tB-LOC\ngrand\tO\nprix\tO\n.\tO\n\nThe\tO\nprevious\tO\nmark\tO\nof\tO\n2:29.34\tO\nwas\tO\nset\tO\nby\tO\nMozambique\tB-LOC\n's\tO\nMaria\tB-PER\nMutola\tI-PER\nhere\tO\non\tO\nAugust\tO\n25\tO\nlast\tO\nyear\tO\n.\tO\n\nGOLF\tO\n-\tO\nGERMAN\tB-MISC\nOPEN\tI-MISC\nSECOND\tO\nROUND\tO\nSCORES\tO\n.\tO\n\nSTUTTGART\tB-LOC\n,\tO\nGermany\tB-LOC\n1996-08-23\tO\n\nscores\tO\nin\tO\nthe\tO\nGerman\tB-MISC\nOpen\tI-MISC\ngolf\tO\nchampionship\tO\non\tO\nFriday\tO\n(\tO\nBritain\tB-LOC\n\n128\tO\nIan\tB-PER\nWoosnam\tI-PER\n64\tO\n64\tO\n\n130\tO\nFernando\tB-PER\nRoca\tI-PER\n(\tO\nSpain\tO\n)\tO\n66\tO\n64\tO\n,\tO\nIan\tO\nPyman\tO\n66\tO\n64\tO\n\n131\tO\nCarl\tB-PER\nSuneson\tI-PER\n65\tO\n66\tO\n,\tO\nStephen\tO\nField\tO\n66\tO\n65\tO\n\n132\tO\nMiguel\tO\nAngel\tO\nMartin\tO\n(\tO\nSpain\tB-LOC\n)\tO\n66\tO\n66\tO\n,\tO\nRaymond\tB-PER\nRussell\tI-PER\n63\tO\n69\tO\n,\tO\n\nThomas\tB-PER\nGogele\tI-PER\n(\tO\nGermany\tO\n)\tO\n67\tO\n65\tO\n,\tO\nPaul\tB-PER\nBroadhurst\tI-PER\n62\tO\n70\tO\n,\tO\n\nDiego\tB-PER\nBorrego\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n69\tO\n63\tO\n\n133\tO\nRicky\tO\nWillison\tO\n69\tO\n64\tO\n,\tO\nStephen\tB-PER\nAmes\tI-PER\n(\tO\nTrinidad\tO\nand\tO\nTobago\tO\n)\tO\n\n68\tO\n65\tO\n,\tO\nEamonn\tB-PER\nDarcy\tI-PER\n(\tO\nIreland\tB-LOC\n)\tO\n65\tO\n68\tO\n\n134\tO\nRobert\tB-PER\nColes\tI-PER\n68\tO\n66\tO\n,\tO\nDavid\tB-PER\nWilliams\tI-PER\n67\tO\n67\tO\n,\tO\nThomas\tB-PER\nBjorn\tI-PER\n\n(\tO\nDenmark\tB-LOC\n)\tO\n66\tO\n68\tO\n,\tO\nPedro\tB-PER\nLinhart\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n67\tO\n67\tO\n,\tO\nMichael\tB-PER\n\nJonzon\tB-PER\n(\tO\nSweden\tB-LOC\n)\tO\n67\tO\n67\tO\n,\tO\nRoger\tB-PER\nChapman\tI-PER\n72\tO\n62\tO\n,\tO\nJonathan\tB-PER\nLomas\tI-PER\n\n67\tO\n67\tO\n,\tO\nFrancisco\tB-PER\nCea\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n68\tO\n66\tO\n\n135\tO\nTerry\tB-PER\nPrice\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n67\tO\n68\tO\n,\tO\nPaul\tB-PER\nEales\tI-PER\n67\tO\n68\tO\n,\tO\nWayne\tO\n\nRiley\tB-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n64\tO\n71\tO\n,\tO\nCarl\tB-PER\nMason\tI-PER\n69\tO\n66\tO\n,\tO\nBarry\tB-PER\nLane\tI-PER\n\n68\tO\n67\tO\n,\tO\nBernhard\tB-PER\nLanger\tI-PER\n(\tO\nGermany\tO\n)\tO\n64\tO\n71\tO\n,\tO\nGary\tB-PER\nOrr\tI-PER\n67\tO\n68\tO\n,\tO\n\nMats\tB-PER\nLanner\tI-PER\n(\tO\nSweden\tO\n)\tO\n64\tO\n71\tO\n,\tO\nJeff\tB-PER\nHawksworth\tI-PER\n67\tO\n68\tO\n,\tO\nDes\tB-PER\n\nSmyth\tO\n(\tO\nIreland\tB-LOC\n)\tO\n66\tO\n69\tO\n,\tO\nDavid\tB-PER\nCarter\tI-PER\n66\tO\n69\tO\n,\tO\nSteve\tB-PER\nWebster\tI-PER\n\n69\tO\n66\tO\n,\tO\nJose\tB-PER\nMaria\tI-PER\nCanizares\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n67\tO\n68\tO\n,\tO\nPaul\tB-PER\nLawrie\tI-PER\n\nATHLETICS\tO\n-\tO\nMITCHELL\tO\nUPSTAGES\tO\nTRIO\tO\nOF\tO\nOLYMPIC\tB-MISC\nSPRINT\tO\nCHAMPIONS\tO\n.\tO\n\nAmerican\tB-MISC\nDennis\tB-PER\nMitchell\tI-PER\nupstaged\tO\na\tO\ntrio\tO\nof\tO\npast\tO\nand\tO\npresent\tO\nOlympic\tB-MISC\n100\tO\nmetres\tO\nchampions\tO\non\tO\nFriday\tO\nwith\tO\na\tO\nstorming\tO\nvictory\tO\nat\tO\nthe\tO\nBrussels\tB-LOC\ngrand\tO\nprix\tO\n.\tO\n\nSporting\tB-ORG\nhis\tO\ncustomary\tO\nbright\tO\ngreen\tO\noutfit\tO\n,\tO\nthe\tO\nU.S.\tB-LOC\nchampion\tO\nclocked\tO\n10.03\tO\nseconds\tO\ndespite\tO\ndamp\tO\nconditions\tO\nto\tO\ntake\tO\nthe\tO\nscalp\tO\nof\tO\nCanada\tB-LOC\n's\tO\nreigning\tO\nOlympic\tB-MISC\nchampion\tO\nDonovan\tB-PER\nBailey\tI-PER\n,\tO\n1992\tO\nchampion\tO\nLinford\tB-PER\nChristie\tI-PER\nof\tO\nBritain\tB-LOC\nand\tO\nAmerican\tB-MISC\n1984\tO\nand\tO\n1988\tO\nchampion\tO\nCarl\tB-PER\nLewis\tI-PER\n.\tO\n\nMitchell\tB-PER\nalso\tO\nbeat\tO\nworld\tO\nand\tO\nOlympic\tB-MISC\nchampion\tO\nBailey\tO\nat\tO\nthe\tO\nmost\tO\nlucrative\tO\nmeeting\tO\nin\tO\nthe\tO\nsport\tO\nin\tO\nZurich\tB-LOC\nlast\tO\nweek\tO\n.\tO\n\nThe\tO\nAmerican\tB-MISC\n,\tO\nwho\tO\nfinished\tO\nfourth\tO\nat\tO\nthe\tO\nAtlanta\tB-MISC\nGames\tI-MISC\n,\tO\nwas\tO\nfast\tO\nout\tO\nof\tO\nhis\tO\nblocks\tO\nand\tO\nheld\tO\noff\tO\nBailey\tB-PER\n's\tO\nlate\tO\nburst\tO\nin\tO\nthe\tO\nfinal\tO\n20\tO\nmetres\tO\nbefore\tO\nheading\tO\noff\tO\nfor\tO\na\tO\nlap\tO\nof\tO\ncelebration\tO\n.\tO\n\nThe\tO\nCanadian\tB-MISC\nwas\tO\nsecond\tO\nin\tO\n10.09\tO\nwith\tO\nLewis\tB-PER\nthird\tO\nin\tO\n10.10\tO\n,\tO\nahead\tO\nof\tO\nAtlanta\tB-LOC\nbronze\tO\nmedallist\tO\nAto\tB-PER\nBoldon\tI-PER\nwho\tO\nclocked\tO\n10.12\tO\nin\tO\nfourth\tO\n.\tO\n\nChristie\tB-PER\n,\tO\ncompeting\tO\nin\tO\nwhat\tO\nis\tO\nexpected\tO\nto\tO\nbe\tO\nhis\tO\nlast\tO\nmajor\tO\ninternational\tO\nmeeting\tO\n,\tO\nfinished\tO\nfifth\tO\nin\tO\n10.14\tO\n.\tO\n\nLewis\tB-PER\n,\tO\nmaking\tO\na\tO\nrare\tO\nappearance\tO\nin\tO\nEurope\tB-LOC\nin\tO\na\tO\nsprint\tO\nrace\tO\n,\tO\nleft\tO\nthe\tO\ntrack\tO\nwith\tO\na\tO\nslight\tO\nlimp\tO\n.\tO\n\nAmerican\tB-MISC\nOlympic\tI-MISC\nhigh\tO\nhurdles\tO\nchampion\tO\nAllen\tB-PER\nJohnson\tI-PER\ndefied\tO\nthe\tO\nwet\tO\nconditions\tO\nto\tO\nproduce\tO\na\tO\nbrilliant\tO\n12.92\tO\nseconds\tO\nin\tO\nthe\tO\n110\tO\nmetres\tO\nrace\tO\n,\tO\njust\tO\n0.01\tO\noutside\tO\nthe\tO\nworld\tO\nrecord\tO\nheld\tO\nby\tO\nBritain\tB-LOC\n's\tO\nColin\tB-PER\nJackson\tI-PER\n.\tO\n\nJohnson\tB-PER\nran\tO\nthe\tO\nsame\tO\ntime\tO\nat\tO\nthe\tO\nU.S.\tB-LOC\nOlympic\tB-MISC\ntrials\tO\nin\tO\nAtlanta\tB-LOC\nin\tO\nJune\tO\nto\tO\nbecome\tO\nthe\tO\nsecond\tO\nequal\tO\nfastest\tO\nhurdler\tO\nof\tO\nall\tO\ntime\tO\nwith\tO\nAmerican\tB-MISC\nRoger\tB-PER\nKingdom\tI-PER\n.\tO\n\nHe\tO\nseemed\tO\nto\tO\nrelish\tO\nthe\tO\nnew\tO\ntrack\tO\nat\tO\nthe\tO\nBrussels\tB-LOC\nmeeting\tO\n,\tO\ndominating\tO\nthe\tO\nrace\tO\nfrom\tO\nstart\tO\nto\tO\nfinish\tO\nwith\tO\na\tO\nslight\tO\nwind\tO\nat\tO\nhis\tO\nback\tO\n.\tO\n\nJackson\tB-PER\n,\tO\nthe\tO\nonly\tO\nman\tO\nto\tO\nhave\tO\nrun\tO\nfaster\tO\n,\tO\ncould\tO\nnot\tO\nlive\tO\nwith\tO\nhis\tO\nspeed\tO\n,\tO\ntaking\tO\nsecond\tO\nin\tO\n13.24\tO\nseconds\tO\n.\tO\n\nBut\tO\nSweden\tB-LOC\n's\tO\nOlympic\tB-MISC\nhigh\tO\nhurdles\tO\nchampion\tO\nLudmila\tB-PER\nEngquist\tI-PER\n,\tO\nwho\tO\ncrashed\tO\nout\tO\nof\tO\nlast\tO\nweek\tO\n's\tO\nmeeting\tO\nin\tO\nZurich\tB-LOC\nafter\tO\nhitting\tO\na\tO\nhurdle\tO\n,\tO\nalso\tO\nkept\tO\nher\tO\nfooting\tO\nperfectly\tO\nto\tO\nwin\tO\nin\tO\na\tO\nfast\tO\n12.60\tO\nseconds\tO\n.\tO\n\nOlympic\tB-MISC\nsilver\tO\nmedallist\tO\nBrigita\tB-PER\nBukovec\tI-PER\nof\tO\nSlovenia\tB-LOC\ncould\tO\nfinish\tO\nonly\tO\nfifth\tO\nin\tO\nthe\tO\nrace\tO\nin\tO\n12.95\tO\n.\tO\n\nJamaican\tB-MISC\nCommonwealth\tB-ORG\nchampion\tO\nMichelle\tB-PER\nFreeman\tI-PER\ntook\tO\nsecond\tO\nin\tO\n12.77\tO\nahead\tO\nof\tO\nCuban\tB-MISC\nAliuska\tB-PER\nLopez\tI-PER\n.\tO\n\nThe\tO\nZurich\tB-LOC\nfall\tO\ncost\tO\nEngquist\tB-PER\na\tO\nshot\tO\nat\tO\na\tO\njackpot\tO\nof\tO\n20\tO\none-kg\tO\ngold\tO\nbars\tO\nwhich\tO\ncan\tO\nbe\tO\nwon\tO\nby\tO\nathletes\tO\nwho\tO\nclinch\tO\ntheir\tO\nevents\tO\nat\tO\nall\tO\nof\tO\nthe\tO\nGolden\tB-MISC\nFour\tI-MISC\nseries\tO\nin\tO\nOslo\tB-LOC\n,\tO\nZurich\tB-LOC\n,\tO\nBrussels\tB-LOC\nand\tO\nBerlin\tB-LOC\n.\tO\n\nSeven\tO\nathletes\tO\nwent\tO\ninto\tO\nFriday\tO\n's\tO\npenultimate\tO\nmeeting\tO\nof\tO\nthe\tO\nseries\tO\nwith\tO\na\tO\nchance\tO\nof\tO\nwinning\tO\nthe\tO\nprize\tO\nand\tO\nAmerican\tB-MISC\nmen\tO\n's\tO\n400\tO\nmetres\tO\nhurdles\tO\nchampion\tO\nDerrick\tB-PER\nAdkins\tI-PER\nkept\tO\nhis\tO\nhopes\tO\nalive\tO\nin\tO\nthe\tO\ncompetition\tO\nby\tO\nwinning\tO\nhis\tO\nevent\tO\nin\tO\n47.93\tO\n.\tO\n\nAmerican\tB-MISC\nOlympic\tI-MISC\nchampion\tO\nGail\tB-PER\nDevers\tI-PER\nclocked\tO\na\tO\nswift\tO\n10.84\tO\nseconds\tO\non\tO\nher\tO\nway\tO\nto\tO\nvictory\tO\nin\tO\nthe\tO\nwomen\tO\n's\tO\n100\tO\nmetres\tO\n,\tO\nthe\tO\nsecond\tO\nfastest\tO\ntime\tO\nof\tO\nthe\tO\nseason\tO\nand\tO\n0.10\tO\nseconds\tO\nfaster\tO\nthan\tO\nher\tO\nwinning\tO\ntime\tO\nin\tO\nAtlanta\tB-LOC\n.\tO\n\nJamaican\tB-MISC\nveteran\tO\nMerlene\tB-PER\nOttey\tI-PER\n,\tO\nwho\tO\nbeat\tO\nDevers\tB-PER\nin\tO\nZurich\tB-LOC\nafter\tO\njust\tO\nmissing\tO\nout\tO\non\tO\nthe\tO\ngold\tO\nmedal\tO\nin\tO\nAtlanta\tB-LOC\nafter\tO\na\tO\nphoto\tO\nfinish\tO\n,\tO\nhad\tO\nto\tO\nsettle\tO\nfor\tO\nthird\tO\nplace\tO\nin\tO\n11.04\tO\n.\tO\n\nAmerican\tB-MISC\nworld\tO\nchampion\tO\nGwen\tB-PER\nTorrence\tI-PER\n,\tO\nthe\tO\nbronze\tO\nmedallist\tO\nin\tO\nAtlanta\tB-LOC\n,\tO\nwas\tO\nsecond\tO\nin\tO\n11.00\tO\n.\tO\n\nIt\tO\nwas\tO\na\tO\ncostly\tO\ndefeat\tO\nfor\tO\nOttey\tB-PER\nsince\tO\nit\tO\nthrew\tO\nher\tO\nout\tO\nof\tO\nthe\tO\nrace\tO\nfor\tO\nthe\tO\nGolden\tB-MISC\nFour\tI-MISC\njackpot\tO\n.\tO\n\nATHLETICS\tO\n-\tO\nBRUSSELS\tB-MISC\nGRAND\tI-MISC\nPRIX\tI-MISC\nRESULTS\tO\n.\tO\n\nLeading\tO\nresults\tO\nin\tO\nthe\tO\nBrussels\tB-MISC\n\nGrand\tB-MISC\nPrix\tI-MISC\nathletics\tO\nmeeting\tO\non\tO\nFriday\tO\n:\tO\n\n1.\tO\nIlke\tB-PER\nWyludda\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\n66.60\tO\nmetres\tO\n\n2.\tO\nEllina\tB-PER\nZvereva\tI-PER\n(\tO\nBelarus\tO\n)\tO\n65.66\tO\n\n3.\tO\nFranka\tB-PER\nDietzsch\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\n61.74\tO\n\n4.\tO\nNatalya\tB-PER\nSadova\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n61.64\tO\n\n5.\tO\nMette\tB-PER\nBergmann\tI-PER\n(\tO\nNorway\tB-LOC\n)\tO\n61.44\tO\n\n6.\tO\nNicoleta\tB-PER\nGrasu\tI-PER\n(\tO\nRomania\tB-LOC\n)\tO\n61.36\tO\n\n7.\tO\nOlga\tB-PER\nChernyavskaya\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n60.46\tO\n\n8.\tO\nIrina\tO\nYatchenko\tO\n(\tO\nBelarus\tB-LOC\n)\tO\n58.92\tO\n\n1.\tO\nLudmila\tB-PER\nEngquist\tI-PER\n(\tO\nSweden\tB-LOC\n)\tO\n12.60\tO\nseconds\tO\n\n2.\tO\nMichelle\tB-PER\nFreeman\tI-PER\n(\tO\nJamaica\tO\n)\tO\n12.77\tO\n\n3.\tO\nAliuska\tB-PER\nLopez\tI-PER\n(\tO\nCuba\tB-LOC\n)\tO\n12.85\tO\n\n4.\tO\nDionne\tB-PER\nRose\tI-PER\n(\tO\nJamaica\tB-LOC\n)\tO\n12.88\tO\n\n5.\tO\nBrigita\tB-PER\nBukovec\tI-PER\n(\tO\nSlovakia\tB-LOC\n)\tO\n12.95\tO\n\n6.\tO\nYulia\tB-PER\nGraudin\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n12.96\tO\n\n7.\tO\nJulie\tB-PER\nBaumann\tI-PER\n(\tO\nSwitzerland\tO\n)\tO\n13.36\tO\n\n8.\tO\nPatricia\tB-PER\nGirard-Leno\tI-PER\n(\tO\nFrance\tO\n)\tO\n13.36\tO\n\n9.\tO\nDawn\tB-PER\nBowles\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n13.53\tO\n\n1.\tO\nAllen\tB-PER\nJohnson\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n12.92\tO\nseconds\tO\n\n2.\tO\nColin\tB-PER\nJackson\tI-PER\n(\tO\nBritain\tB-LOC\n)\tO\n13.24\tO\n\n3.\tO\nEmilio\tB-PER\nValle\tI-PER\n(\tO\nCuba\tO\n)\tO\n13.33\tO\n\n4.\tO\nSven\tB-PER\nPieters\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\n13.37\tO\n\n6.\tO\nFrank\tB-PER\nAsselman\tI-PER\n(\tO\nBelgium\tO\n)\tO\n13.64\tO\n\n7.\tO\nHubert\tB-PER\nGrossard\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\n13.65\tO\n\n8.\tO\nJonathan\tB-PER\nN'Senga\tI-PER\n(\tO\nBelgium\tO\n)\tO\n13.66\tO\n\n9.\tO\nJohan\tB-PER\nLisabeth\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\n13.75\tO\n\n1.\tO\nRoberta\tB-PER\nBrunet\tI-PER\n(\tO\nItaly\tB-LOC\n)\tO\n14\tO\nminutes\tO\n48.96\tO\nseconds\tO\n\n2.\tO\nFernanda\tB-PER\nRibeiro\tI-PER\n(\tO\nPortugal\tO\n)\tO\n14:49.81\tO\n\n3.\tO\nSally\tB-PER\nBarsosio\tI-PER\n(\tO\nKenya\tB-LOC\n)\tO\n14:58.29\tO\n\n5.\tO\nJulia\tB-PER\nVaquero\tI-PER\n(\tO\nSpain\tO\n)\tO\n15:04.94\tO\n\n6.\tO\nCatherine\tB-PER\nMcKiernan\tI-PER\n(\tO\nIreland\tO\n)\tO\n15:07.57\tO\n\n7.\tO\nAnnette\tB-PER\nPeters\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n15:07.85\tO\n\n8.\tO\nPauline\tB-PER\nKonga\tI-PER\n(\tO\nKenya\tB-LOC\n)\tO\n15:11.40\tO\n\n1.\tO\nDennis\tO\nMitchell\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n10.03\tO\nseconds\tO\n\n2.\tO\nDonovan\tO\nBailey\tO\n(\tO\nCanada\tB-LOC\n)\tO\n10.09\tO\n\n3.\tO\nCarl\tO\nLewis\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n10.10\tO\n\n4.\tO\nAto\tB-PER\nBoldon\tI-PER\n(\tO\nTrinidad\tB-LOC\n)\tO\n10.12\tO\n\n5.\tO\nLinford\tO\nChristie\tO\n(\tO\nBritain\tB-LOC\n)\tO\n10.14\tO\n\n7.\tO\nJon\tB-PER\nDrummond\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n10.16\tO\n\n8.\tO\nBruny\tB-PER\nSurin\tI-PER\n(\tO\nCanada\tB-LOC\n)\tO\n10.30\tO\n\n1.\tO\nDerrick\tB-PER\nAdkins\tI-PER\n(\tO\nU.S.\tO\n)\tO\n47.93\tO\nseconds\tO\n\n2.\tO\nSamuel\tB-PER\nMatete\tI-PER\n(\tO\nZambia\tB-LOC\n)\tO\n47.99\tO\n\n3.\tO\nRohan\tB-PER\nRobinson\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n48.86\tO\n\n4.\tO\nTorrance\tB-PER\nZellner\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n49.06\tO\n\n5.\tO\nJean-Paul\tB-PER\nBruwier\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\n49.24\tO\n\n6.\tO\nDusan\tO\nKovacs\tO\n(\tO\nHungary\tB-LOC\n)\tO\n49.31\tO\n\n7.\tO\nCalvin\tB-PER\nDavis\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n49.49\tO\n\n8.\tO\nLaurent\tB-PER\nOttoz\tI-PER\n(\tO\nItaly\tB-LOC\n)\tO\n49.61\tO\n\n9.\tO\nMarc\tB-PER\nDollendorf\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\n50.36\tO\n\n1.\tO\nGail\tB-PER\nDevers\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n10.84\tO\nseconds\tO\n\n2.\tO\nGwen\tB-PER\nTorrence\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n11.00\tO\n\n3.\tO\nMerlene\tB-PER\nOttey\tI-PER\n(\tO\nJamaica\tB-LOC\n)\tO\n11.04\tO\n\n4.\tO\nMary\tB-PER\nOnyali\tI-PER\n(\tO\nNigeria\tB-LOC\n)\tO\n11.09\tO\n\n5.\tO\nChryste\tO\nGaines\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n11.18\tO\n\n6.\tO\nZhanna\tB-PER\nPintusevich\tI-PER\n(\tO\nUkraine\tB-LOC\n)\tO\n11.27\tO\n\n7.\tO\nIrina\tB-PER\nPrivalova\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n11.28\tO\n\n8.\tO\nNatalia\tB-PER\nVoronova\tI-PER\n(\tO\nRussia\tO\n)\tO\n11.28\tO\n\n9.\tO\nJuliet\tB-PER\nCuthbert\tI-PER\n(\tO\nJamaica\tB-LOC\n)\tO\n11.31\tO\n\n1.\tO\nRegina\tB-PER\nJacobs\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n4\tO\nminutes\tO\n01.77\tO\nseconds\tO\n\n2.\tO\nPatricia\tB-PER\nDjate\tI-PER\n(\tO\nFrance\tO\n)\tO\n4:02.26\tO\n\n3.\tO\nCarla\tB-PER\nSacramento\tI-PER\n(\tO\nPortugal\tB-LOC\n)\tO\n4:02.67\tO\n\n5.\tO\nMargret\tB-PER\nCrowley\tI-PER\n(\tO\nAustralia\tO\n)\tO\n4:05.00\tO\n\n6.\tO\nLeah\tO\nPells\tO\n(\tO\nCanada\tB-LOC\n)\tO\n4:05.64\tO\n\n7.\tO\nSarah\tB-PER\nThorsett\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n4:06.80\tO\n\n8.\tO\nSinead\tB-PER\nDelahunty\tI-PER\n(\tO\nIreland\tO\n)\tO\n4:07.27\tO\n\n1.\tO\nJoseph\tB-PER\nKeter\tI-PER\n(\tO\nKenya\tO\n)\tO\n8\tO\nminutes\tO\n10.02\tO\nseconds\tO\n\n2.\tO\nPatrick\tO\nSang\tO\n(\tO\nKenya\tB-LOC\n)\tO\n8:12.04\tO\n\n3.\tO\nMoses\tO\nKiptanui\tO\n(\tO\nKenya\tB-LOC\n)\tO\n8:12.65\tO\n\n4.\tO\nGideon\tB-PER\nChirchir\tI-PER\n(\tO\nKenya\tB-LOC\n)\tO\n8:15.69\tO\n\n5.\tO\nRichard\tB-PER\nKosgei\tI-PER\n(\tO\nKenya\tB-LOC\n)\tO\n8:16.80\tO\n\n6.\tO\nLarbi\tO\nEl\tO\nKhattabi\tO\n(\tO\nMorocco\tB-LOC\n)\tO\n8:17.29\tO\n\n7.\tO\nEliud\tB-PER\nBarngetuny\tI-PER\n(\tO\nKenya\tB-LOC\n)\tO\n8:17.66\tO\n\n8.\tO\nBernard\tB-PER\nBarmasai\tI-PER\n(\tO\nKenya\tO\n)\tO\n8:17.94\tO\n\n1.\tO\nMichael\tB-PER\nJohnson\tI-PER\n(\tO\nU.S.\tO\n)\tO\n44.29\tO\nseconds\tO\n\n2.\tO\nDerek\tB-PER\nMills\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n44.78\tO\n\n3.\tO\nAnthuan\tB-PER\nMaybank\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n44.92\tO\n\n4.\tO\nDavis\tB-PER\nKamoga\tI-PER\n(\tO\nUganda\tB-LOC\n)\tO\n44.96\tO\n\n5.\tO\nJamie\tO\nBaulch\tO\n(\tO\nBritain\tB-LOC\n)\tO\n45.08\tO\n\n6.\tO\nSunday\tB-PER\nBada\tI-PER\n(\tO\nNigeria\tB-LOC\n)\tO\n45.21\tO\n\n7.\tO\nSamson\tB-PER\nKitur\tI-PER\n(\tO\nKenya\tO\n)\tO\n45.34\tO\n\n8.\tO\nMark\tB-PER\nRichardson\tI-PER\n(\tO\nBritain\tB-LOC\n)\tO\n45.67\tO\n\n9.\tO\nJason\tB-PER\nRouser\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n46.11\tO\n\n1.\tO\nFrankie\tB-PER\nFredericks\tI-PER\n(\tO\nNamibia\tB-LOC\n)\tO\n19.92\tO\nseconds\tO\n\n2.\tO\nAto\tB-PER\nBoldon\tI-PER\n(\tO\nTrinidad\tB-LOC\n)\tO\n19.99\tO\n\n3.\tO\nJeff\tB-PER\nWilliams\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n20.21\tO\n\n4.\tO\nJon\tO\nDrummond\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n20.42\tO\n\n5.\tO\nPatrick\tO\nStevens\tO\n(\tO\nBelgium\tB-LOC\n)\tO\n20.42\tO\n\n6.\tO\nMichael\tB-PER\nMarsh\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n20.43\tO\n\n8.\tO\nEric\tB-PER\nWymeersch\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\n20.84\tO\n\n1.\tO\nSvetlana\tB-PER\nMasterkova\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n2\tO\nminutes\tO\n28.98\tO\nseconds\tO\n\n2.\tO\nMaria\tB-PER\nMutola\tI-PER\n(\tO\nMozambique\tO\n)\tO\n2:29.66\tO\n\n3.\tO\nMalgorzata\tB-PER\nRydz\tI-PER\n(\tO\nPoland\tB-LOC\n)\tO\n2:39.00\tO\n\n4.\tO\nAnja\tO\nSmolders\tO\n(\tO\nBelgium\tB-LOC\n)\tO\n2:43.06\tO\n\n5.\tO\nVeerle\tB-PER\nDe\tI-PER\nJaeghere\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\n2:43.18\tO\n\n6.\tO\nEleonora\tB-PER\nBerlanda\tI-PER\n(\tO\nItaly\tO\n)\tO\n2:43.44\tO\n\n7.\tO\nAnneke\tB-PER\nMatthijs\tI-PER\n(\tO\nBelgium\tB-LOC\n)\tO\n2:43.82\tO\n\n8.\tO\nJacqueline\tO\nMartin\tO\n(\tO\nSpain\tB-LOC\n)\tO\n2:44.22\tO\n\n1.\tO\nMary\tB-PER\nOnyali\tI-PER\n(\tO\nNigeria\tB-LOC\n)\tO\n22.42\tO\nseconds\tO\n\n2.\tO\nInger\tB-PER\nMiller\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n22.66\tO\n\n3.\tO\nIrina\tB-PER\nPrivalova\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n22.68\tO\n\n4.\tO\nNatalia\tB-PER\nVoronova\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n22.73\tO\n\n5.\tO\nMarina\tB-PER\nTrandenkova\tI-PER\n(\tO\nRussia\tO\n)\tO\n22.84\tO\n\n6.\tO\nChandra\tB-PER\nSturrup\tI-PER\n(\tO\nBahamas\tB-LOC\n)\tO\n22.85\tO\n\n7.\tO\nZundra\tB-PER\nFeagin\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n23.18\tO\n\n8.\tO\nGalina\tB-PER\nMalchugina\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n23.25\tO\n\n1.\tO\nCathy\tB-PER\nFreeman\tI-PER\n(\tO\nAustralia\tB-LOC\n)\tO\n49.48\tO\nseconds\tO\n\n2.\tO\nMarie-Jose\tB-PER\nPerec\tI-PER\n(\tO\nFrance\tB-LOC\n)\tO\n49.72\tO\n\n3.\tO\nFalilat\tB-PER\nOgunkoya\tI-PER\n(\tO\nNigeria\tB-LOC\n)\tO\n49.97\tO\n\n4.\tO\nPauline\tB-PER\nDavis\tI-PER\n(\tO\nBahamas\tO\n)\tO\n50.14\tO\n\n5.\tO\nFatima\tB-PER\nYussuf\tI-PER\n(\tO\nNigeria\tB-LOC\n)\tO\n50.14\tO\n\n6.\tO\nMaicel\tB-PER\nMalone\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n50.51\tO\n\n7.\tO\nHana\tB-PER\nBenesova\tI-PER\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n51.71\tO\n\n8.\tO\nAnn\tB-PER\nMercken\tI-PER\n(\tO\nBelgium\tO\n)\tO\n53.55\tO\n\n1.\tO\nDaniel\tB-PER\nKomen\tI-PER\n(\tO\nKenya\tO\n)\tO\n7\tO\nminutes\tO\n25.87\tO\nseconds\tO\n\n2.\tO\nKhalid\tO\nBoulami\tO\n(\tO\nMorocco\tB-LOC\n)\tO\n7:31.65\tO\n\n3.\tO\nBob\tB-PER\nKennedy\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n7:31.69\tO\n\n4.\tO\nEl\tB-PER\nHassane\tI-PER\nLahssini\tI-PER\n(\tO\nMorocco\tB-LOC\n)\tO\n7:32.44\tO\n\n5.\tO\nThomas\tB-PER\nNyariki\tI-PER\n(\tO\nKenya\tB-LOC\n)\tO\n7:35.56\tO\n\n6.\tO\nNoureddine\tO\nMorceli\tO\n(\tO\nAlgeria\tB-LOC\n)\tO\n7:36.81\tO\n\n7.\tO\nFita\tB-PER\nBayesa\tI-PER\n(\tO\nEthiopia\tO\n)\tO\n7:38.09\tO\n\n8.\tO\nMartin\tB-PER\nKeino\tI-PER\n(\tO\nKenya\tO\n)\tO\n7:38.88\tO\n\n1.\tO\nLars\tO\nRiedel\tO\n(\tO\nGermany\tB-LOC\n)\tO\n66.74\tO\nmetres\tO\n\n2.\tO\nAnthony\tB-PER\nWashington\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n66.72\tO\n\n3.\tO\nVladimir\tB-PER\nDubrovshchik\tI-PER\n(\tO\nBelarus\tB-LOC\n)\tO\n64.02\tO\n\n4.\tO\nVirgilius\tB-PER\nAlekna\tI-PER\n(\tO\nLithuania\tO\n)\tO\n63.62\tO\n\n5.\tO\nJuergen\tB-PER\nSchult\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\n63.48\tO\n\n7.\tO\nVaclavas\tB-PER\nKidikas\tI-PER\n(\tO\nLithuania\tB-LOC\n)\tO\n60.92\tO\n\n1.\tO\nJonathan\tO\nEdwards\tO\n(\tO\nBritain\tB-LOC\n)\tO\n17.50\tO\nmetres\tO\n\n2.\tO\nYoelvis\tB-PER\nQuesada\tI-PER\n(\tO\nCuba\tO\n)\tO\n17.29\tO\n\n3.\tO\nBrian\tB-PER\nWellman\tI-PER\n(\tO\nBermuda\tB-LOC\n)\tO\n17.05\tO\n\n4.\tO\nKenny\tB-PER\nHarrison\tI-PER\n(\tO\nU.S.\tB-LOC\n)\tO\n16.97\tO\n\n5.\tO\nGennadi\tO\nMarkov\tO\n(\tO\nRussia\tB-LOC\n)\tO\n16.66\tO\n\n6.\tO\nFrancis\tB-PER\nAgyepong\tI-PER\n(\tO\nBritain\tB-LOC\n)\tO\n16.63\tO\n\n7.\tO\nRogel\tB-PER\nNachum\tI-PER\n(\tO\nIsrael\tB-LOC\n)\tO\n16.36\tO\n\n8.\tO\nSigurd\tB-PER\nNjerve\tI-PER\n(\tO\nNorway\tO\n)\tO\n16.35\tO\n\n1.\tO\nHicham\tB-PER\nEl\tI-PER\nGuerrouj\tI-PER\n(\tO\nMorocco\tB-LOC\n)\tO\nthree\tO\nminutes\tO\n29.05\tO\nseconds\tO\n\n3.\tO\nWilliam\tB-PER\nTanui\tI-PER\n(\tO\nKenya\tB-LOC\n)\tO\n3:33.36\tO\n\n4.\tO\nElijah\tB-PER\nMaru\tI-PER\n(\tO\nKenya\tB-LOC\n)\tO\n3:33.64\tO\n\n5.\tO\nMarcus\tO\nO'Sullivan\tO\n(\tO\nIreland\tB-LOC\n)\tO\n3:33.77\tO\n\n6.\tO\nJohn\tB-PER\nMayock\tI-PER\n(\tO\nBritain\tO\n)\tO\n3:33.94\tO\n\n8.\tO\nChristophe\tB-PER\nImpens\tI-PER\n(\tO\nBelgium\tO\n)\tO\n3:34.13\tO\n\n1.\tO\nStefka\tO\nKostadinova\tO\n(\tO\nBulgaria\tB-LOC\n)\tO\n2.03\tO\nmetres\tO\n\n2.\tO\nInga\tB-PER\nBabakova\tI-PER\n(\tO\nUkraine\tB-LOC\n)\tO\n2.03\tO\n\n3.\tO\nAlina\tB-PER\nAstafei\tI-PER\n(\tO\nGermany\tB-LOC\n)\tO\n1.97\tO\n\n4.\tO\nTatyana\tB-PER\nMotkova\tI-PER\n(\tO\nRussia\tO\n)\tO\n1.94\tO\n\n6.\tO\nYelena\tB-PER\nGulyayeva\tI-PER\n(\tO\nRussia\tB-LOC\n)\tO\n1.88\tO\n\n7.\tO\nHanna\tB-PER\nHaugland\tI-PER\n(\tO\nNorway\tO\n)\tO\n1.88\tO\n\nOlga\tB-PER\nBoshova\tI-PER\n(\tO\nMoldova\tO\n)\tO\n1.85\tO\n\n1.\tO\nSalah\tB-PER\nHissou\tI-PER\n(\tO\nMorocco\tO\n)\tO\n26\tO\nminutes\tO\n38.08\tO\nseconds\tO\n(\tO\nworld\tO\n\n2.\tO\nPaul\tB-PER\nTergat\tI-PER\n(\tO\nKenya\tB-LOC\n)\tO\n26:54.41\tO\n\n3.\tO\nPaul\tO\nKoech\tO\n(\tO\nKenya\tB-LOC\n)\tO\n26:56.78\tO\n\n4.\tO\nWilliam\tO\nKiptum\tO\n(\tO\nKenya\tB-LOC\n)\tO\n27:18.84\tO\n\n6.\tO\nMathias\tB-PER\nNtawulikura\tI-PER\n(\tO\nRwanda\tB-LOC\n)\tO\n27:25.48\tO\n\n7.\tO\nAbel\tB-PER\nAnton\tI-PER\n(\tO\nSpain\tB-LOC\n)\tO\n28:18.44\tO\n\n8.\tO\nKamiel\tB-PER\nMaase\tI-PER\n(\tO\nNetherlands\tB-LOC\n)\tO\n28.29.42\tO\n\n9.\tO\nWorku\tB-PER\nBekila\tI-PER\n(\tO\nEthiopia\tB-LOC\n)\tO\n28.42.23\tO\n\n10.\tO\nRobert\tB-PER\nStefko\tI-PER\n(\tO\nSlovakia\tB-LOC\n)\tO\n28:42.26\tO\n\nSOCCER\tO\n-\tO\nJORGE\tB-PER\nCALLS\tO\nUP\tO\nSIX\tO\nPORTO\tB-ORG\nPLAYERS\tO\nFOR\tO\nWORLD\tB-MISC\nCUP\tI-MISC\nQUALIFIER\tO\n.\tO\n\nPortugal\tB-LOC\n's\tO\nnew\tO\ncoach\tO\nArtur\tB-PER\nJorge\tI-PER\ncalled\tO\nup\tO\nsix\tO\nplayers\tO\nfrom\tO\nleague\tO\nchampions\tO\nPorto\tB-ORG\non\tO\nFriday\tO\nin\tO\nan\tO\n18-man\tO\nsquad\tO\nfor\tO\nthe\tO\nopening\tO\nWorld\tB-MISC\nCup\tI-MISC\nqualifier\tO\nagainst\tO\nArmenia\tB-LOC\non\tO\nAugust\tO\n31\tO\n.\tO\n\nMidfielder\tO\nPaulo\tB-PER\nSousa\tI-PER\n,\tO\nrecently\tO\ntransferred\tO\nto\tO\nBorussia\tB-ORG\nDortmund\tI-ORG\nfrom\tO\nItaly\tB-LOC\n's\tO\nJuventus\tB-ORG\n,\tO\nis\tO\nthe\tO\nonly\tO\nleading\tO\nmember\tO\nof\tO\nthe\tO\nPortuguese\tB-MISC\nside\tO\nfrom\tO\nthis\tO\nyear\tO\n's\tO\nEuropean\tB-MISC\nchampionships\tO\nwho\tO\nwill\tO\nnot\tO\nmake\tO\nthe\tO\ntrip\tO\n.\tO\n\nIt\tO\nwill\tO\nbe\tO\nJorge\tB-PER\n's\tO\nfirst\tO\ngame\tO\nin\tO\ncharge\tO\nof\tO\nthe\tO\nnational\tO\nsquad\tO\nsince\tO\ntaking\tO\nover\tO\nfrom\tO\nAntonio\tB-PER\nOliveira\tI-PER\n,\tO\nwho\tO\nnow\tO\ncoaches\tO\nPorto\tB-ORG\n,\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nEuro\tB-MISC\n96\tI-MISC\n.\tO\n\nGoalkeepers\tO\n-\tO\nVitor\tB-PER\nBaia\tI-PER\n,\tO\nRui\tB-PER\nCorreia\tI-PER\n.\tO\n\nDefenders\tO\n-\tO\nJorge\tO\nCosta\tO\n,\tO\nPaulinho\tB-PER\nSantos\tI-PER\n,\tO\nHelder\tB-PER\nCristovao\tI-PER\n,\tO\nCarlos\tB-PER\nSecretario\tI-PER\n,\tO\nDimas\tB-PER\nTeixeira\tI-PER\n,\tO\nFernando\tO\nCouto\tO\n.\tO\n\nMidfielders\tO\n-\tO\nJose\tB-PER\nBarroso\tI-PER\n,\tO\nLuis\tB-PER\nFigo\tI-PER\n,\tO\nRui\tB-PER\nBarros\tI-PER\n,\tO\nRui\tO\nCosta\tO\n,\tO\nOceano\tB-PER\nCruz\tI-PER\n,\tO\nRicardo\tB-PER\nSa\tI-PER\nPinto\tI-PER\n.\tO\n\nForwards\tO\n-\tO\nDomingos\tB-PER\nOliveira\tI-PER\n,\tO\nJoao\tO\nVieira\tO\nPinto\tO\n,\tO\nJorge\tB-PER\nCadete\tI-PER\n,\tO\nAntonio\tB-PER\nFolha\tI-PER\n.\tO\n\nSOCCER\tO\n-\tO\nVOGTS\tB-PER\nKEEPS\tO\nFAITH\tO\nWITH\tO\nEURO\tB-MISC\n'\tI-MISC\n96\tI-MISC\nCHAMPIONS\tO\n.\tO\n\nTrainer\tO\nBerti\tB-PER\nVogts\tI-PER\nkept\tO\nfaith\tO\nwith\tO\nhis\tO\nentire\tO\nEuropean\tB-MISC\nchampionship\tO\nwinning\tO\nsquad\tO\nfor\tO\nGermany\tB-LOC\n's\tO\nfirst\tO\nmatch\tO\nsince\tO\ntheir\tO\ntitle\tO\nvictory\tO\n,\tO\na\tO\nfriendly\tO\nin\tO\nPoland\tB-LOC\n.\tO\n\nVogts\tB-PER\npicked\tO\nno\tO\nnew\tO\nplayers\tO\nfor\tO\nthe\tO\nsquad\tO\nfor\tO\nthe\tO\nSeptember\tO\n4\tO\ngame\tO\nin\tO\nZabrze\tB-LOC\n.\tO\n\nInstead\tO\non\tO\nFriday\tO\nhe\tO\nnominated\tO\nall\tO\n23\tO\nEuro\tB-MISC\n'\tI-MISC\n96\tI-MISC\nveterans\tO\nincluding\tO\nBremen\tB-ORG\n's\tO\nJens\tB-PER\nTodt\tI-PER\n,\tO\ncalled\tO\nup\tO\nbefore\tO\nthe\tO\nfinal\tO\nby\tO\nspecial\tO\nUEFA\tB-ORG\ndispensation\tO\n.\tO\n\nHe\tO\nwill\tO\n,\tO\nhowever\tO\n,\tO\nhave\tO\nto\tO\ndo\tO\nwithout\tO\nthe\tO\nDortmund\tB-ORG\ntrio\tO\nof\tO\nlibero\tO\nMatthias\tB-PER\nSammer\tI-PER\n,\tO\nmidfielder\tO\nSteffen\tB-PER\nFreund\tI-PER\nand\tO\ndefender\tO\nRene\tB-PER\nSchneider\tI-PER\n,\tO\nwho\tO\nwere\tO\nall\tO\nformally\tO\nnominated\tO\ndespite\tO\nbeing\tO\ninjured\tO\n.\tO\n\n\"\tO\nThis\tO\nsquad\tO\nis\tO\ncurrently\tO\nthe\tO\nbasis\tO\nof\tO\nmy\tO\nplanning\tO\nfor\tO\nthe\tO\n1998\tO\nWorld\tB-MISC\nCup\tI-MISC\n,\tO\n\"\tO\nVogts\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\nGoalkeepers\tO\n-\tO\nOliver\tB-PER\nKahn\tI-PER\n,\tO\nAndreas\tO\nKoepke\tO\n,\tO\nOliver\tB-PER\nReck\tI-PER\n\nDefenders\tO\n-\tO\nMarkus\tB-PER\nBabbel\tI-PER\n,\tO\nThomas\tB-PER\nHelmer\tI-PER\n,\tO\nJuergen\tO\nKohler\tO\n,\tO\nStefan\tB-PER\nReuter\tI-PER\n,\tO\nMatthias\tB-PER\nSammer\tI-PER\n,\tO\nRene\tB-PER\nSchneider\tI-PER\n\nMidfielders\tO\n-\tO\nMario\tB-PER\nBasler\tI-PER\n,\tO\nMarco\tB-PER\nBode\tI-PER\n,\tO\nDieter\tB-PER\nEilts\tI-PER\n,\tO\nSteffen\tB-PER\nFreund\tI-PER\n,\tO\nThomas\tB-PER\nHaessler\tI-PER\n,\tO\nAndreas\tO\nMoeller\tO\n,\tO\nMehmet\tB-PER\nScholl\tI-PER\n,\tO\nThomas\tB-PER\nStrunz\tI-PER\n,\tO\nJens\tB-PER\nTodt\tI-PER\n,\tO\nChristian\tB-PER\nZiege\tI-PER\n\nForwards\tO\n-\tO\nOliver\tB-PER\nBierhoff\tI-PER\n,\tO\nFredi\tB-PER\nBobic\tI-PER\n,\tO\nJuergen\tO\nKlinsmann\tO\n,\tO\nStefan\tB-PER\nKuntz\tI-PER\n.\tO\n\nSOCCER\tO\n-\tO\nEUROPEAN\tB-MISC\nCUP\tI-MISC\nDRAWS\tO\nFOR\tO\nAEK\tB-ORG\n,\tO\nOLYMPIAKOS\tB-ORG\n,\tO\nPAO\tB-ORG\n.\tO\n\nFollowing\tO\nare\tO\nthe\tO\nEuropean\tB-MISC\nsoccer\tO\n\ndraws\tO\nfor\tO\nthe\tO\nUEFA\tB-ORG\ncup\tO\nand\tO\nthe\tO\ncup\tO\n's\tO\nwinners\tO\ncup\tO\ninvolving\tO\nGreek\tB-MISC\n\nteams\tO\nthat\tO\ntook\tO\nplace\tO\ntoday\tO\nin\tO\nGeneva\tB-LOC\n:\tO\n\nx-AEK\tB-ORG\nAthens\tI-ORG\n(\tO\nGreece\tB-LOC\n)\tO\nv\tO\nChemlon\tB-ORG\nHumenne\tI-ORG\n(\tO\nSlovakia\tB-LOC\n)\tO\n\nx-Olympiakos\tB-ORG\nv\tO\nFerencvaros\tB-ORG\n(\tO\nHungary\tB-LOC\n)\tO\n\nx-PAO\tB-ORG\nv\tO\nLegia\tO\nWarsaw\tO\n(\tO\nPoland\tB-LOC\n)\tO\n\nSOCCER\tO\n-\tO\nEURO\tB-MISC\nCLUB\tO\nCOMPETITION\tO\nFIRST\tO\nROUND\tO\nDRAWS\tO\n.\tO\n\nDraws\tO\nfor\tO\nthe\tO\nfirst\tO\nround\tO\nof\tO\nthe\tO\nEuropean\tB-MISC\nclub\tO\nsoccer\tO\ncompetitions\tO\nmade\tO\non\tO\nFriday\tO\n(\tO\nx\tO\ndenotes\tO\nseeded\tO\nteam\tO\n)\tO\n:\tO\n\nUEFA\tB-MISC\nCup\tI-MISC\nLyngby\tO\n(\tO\nDenmark\tB-LOC\n)\tO\nv\tO\nx-Club\tB-ORG\nBrugge\tI-ORG\n(\tO\nBelgium\tB-LOC\n)\tO\nCasino\tB-ORG\nGraz\tI-ORG\n(\tO\nAustria\tB-LOC\n)\tO\nv\tO\nEkeren\tB-ORG\n(\tO\nBelgium\tB-LOC\n)\tO\nBesiktas\tB-ORG\n(\tO\nTurkey\tB-LOC\n)\tO\nv\tO\nMolenbeek\tB-ORG\n(\tO\nBelgium\tB-LOC\n)\tO\nAlania\tB-ORG\nVladikavkaz\tI-ORG\n(\tO\nRussia\tB-LOC\n)\tO\nv\tO\nx-Anderlecht\tB-ORG\n(\tO\nBelgium\tB-LOC\n)\tO\n\nCup\tB-MISC\nWinners\tI-MISC\n'\tI-MISC\nCup\tI-MISC\nx-Cercle\tB-ORG\nBrugge\tI-ORG\n(\tO\nBelgium\tB-LOC\n)\tO\nv\tO\nBrann\tB-ORG\nBergen\tI-ORG\n(\tO\nNorway\tB-LOC\n)\tO\n\nCRICKET\tO\n-\tO\nSRI\tB-LOC\nLANKA\tI-LOC\nAND\tO\nAUSTRALIA\tB-LOC\nSAY\tO\nRELATIONS\tO\nHAVE\tO\nHEALED\tO\n.\tO\n\nSri\tB-LOC\nLanka\tI-LOC\nand\tO\nAustralia\tB-LOC\nagreed\tO\non\tO\nFriday\tO\nthat\tO\nrelations\tO\nbetween\tO\nthe\tO\ntwo\tO\nteams\tO\nhad\tO\nhealed\tO\nsince\tO\nthe\tO\nSri\tB-MISC\nLankans\tI-MISC\n'\tO\nacrimonious\tO\ntour\tO\nlast\tO\nyear\tO\n.\tO\n\nThe\tO\nSri\tB-MISC\nLankans\tI-MISC\nwere\tO\nfirst\tO\nfound\tO\nguilty\tO\nthen\tO\ncleared\tO\nof\tO\nball\tO\ntampering\tO\nand\tO\noff-spinner\tO\nMuttiah\tB-PER\nMuralitharan\tI-PER\nwas\tO\ncalled\tO\nfor\tO\nthrowing\tO\nduring\tO\na\tO\ncontroversial\tO\nthree-test\tO\nseries\tO\nin\tO\nAustralia\tB-LOC\n.\tO\n\n\"\tO\nOur\tO\nconcern\tO\nis\tO\nto\tO\nget\tO\nout\tO\nthere\tO\nand\tO\nplay\tO\nproper\tO\ncricket\tO\n,\tO\n\"\tO\nSri\tB-LOC\nLanka\tI-LOC\ncaptain\tO\nArjuna\tB-PER\nRanatunga\tI-PER\ntold\tO\na\tO\nnews\tO\nconference\tO\non\tO\nthe\tO\neve\tO\nof\tO\na\tO\nwarmup\tO\nmatch\tO\nbetween\tO\nthe\tO\nWorld\tB-MISC\nCup\tI-MISC\nchampions\tO\nand\tO\na\tO\nWorld\tB-ORG\nXI\tI-ORG\nteam\tO\nscheduled\tO\nfor\tO\nSaturday\tO\n.\tO\n\nAustralian\tB-MISC\nteam\tO\nmanager\tO\nCam\tB-PER\nBattersby\tI-PER\nsaid\tO\nhe\tO\nagreed\tO\nwith\tO\nRanatunga\tB-PER\n.\tO\n\n\"\tO\nI\tO\nbelieve\tO\nrelations\tO\nbetween\tO\nthe\tO\ntwo\tO\nteams\tO\nwill\tO\nbe\tO\nexcellent\tO\n,\tO\n\"\tO\nBatterby\tB-PER\nsaid\tO\n.\tO\n\nThe\tO\nAustralians\tB-MISC\nare\tO\nmaking\tO\ntheir\tO\nfirst\tO\nvisit\tO\nto\tO\nthe\tO\nIndian\tB-LOC\nOcean\tI-LOC\nisland\tO\nsince\tO\nboycotting\tO\na\tO\nWorld\tB-MISC\nCup\tI-MISC\nfixture\tO\nin\tO\nFebruary\tO\nafter\tO\na\tO\nterrorist\tO\nbomb\tO\nin\tO\nColombo\tB-LOC\n.\tO\n\nAustralia\tB-LOC\nhave\tO\nbeen\tO\npromised\tO\nthe\tO\npresence\tO\nof\tO\ncommandos\tO\n,\tO\nsniffer\tO\ndogs\tO\nand\tO\nplainclothes\tO\npolicemen\tO\nto\tO\nensure\tO\na\tO\nlimited\tO\novers\tO\ntournament\tO\nis\tO\ntrouble-free\tO\n.\tO\n\nThe\tO\ntournament\tO\n,\tO\nstarting\tO\non\tO\nAugust\tO\n26\tO\n,\tO\nalso\tO\nincludes\tO\nIndia\tB-LOC\nand\tO\nZimbabwe\tB-LOC\n.\tO\n\nBattersby\tB-PER\nsaid\tO\nhe\tO\nwas\tO\nsatisfied\tO\nwith\tO\nthe\tO\nsecurity\tO\narrangements\tO\n.\tO\n\nSri\tB-MISC\nLankan\tI-MISC\nofficials\tO\nsaid\tO\nthey\tO\nexpected\tO\nheavy\tO\nrain\tO\nwhich\tO\nwashed\tO\nout\tO\na\tO\nwarmup\tO\nmatch\tO\non\tO\nFriday\tO\nshould\tO\ncease\tO\nby\tO\nSaturday\tO\n.\tO\n\nAustralia\tB-LOC\n,\tO\nled\tO\nby\tO\nwicketkeeper\tO\nIan\tB-PER\nHealy\tI-PER\n,\tO\nopened\tO\ntheir\tO\nshort\tO\ntour\tO\nof\tO\nSri\tB-LOC\nLanka\tI-LOC\nwith\tO\na\tO\nfive-run\tO\nwin\tO\nover\tO\nthe\tO\ncountry\tO\n's\tO\nyouth\tO\nteam\tO\non\tO\nThursday\tO\n.\tO\n\n-\tO\nThe\tO\nAngolan\tB-MISC\nChief\tO\nof\tO\nState\tO\naddressed\tO\na\tO\nletter\tO\nto\tO\nUN\tB-ORG\nSecurity\tI-ORG\nCouncil\tI-ORG\nproposing\tO\ndates\tO\nfor\tO\nthe\tO\nconclusion\tO\nof\tO\nthe\tO\npeace\tO\nprocess\tO\nin\tO\nAngola\tB-LOC\n.\tO\n\nHe\tO\nproposed\tO\ndefinite\tO\ndates\tO\n,\tO\nAugust\tO\n25\tO\nfor\tO\nreturn\tO\nof\tO\nUnita\tB-ORG\ngenerals\tO\nto\tO\nthe\tO\njoint\tO\narmy\tO\n,\tO\nSeptember\tO\n5\tO\nfor\tO\nthe\tO\nbeginning\tO\nof\tO\nthe\tO\nformation\tO\nof\tO\nthe\tO\nGovernment\tB-ORG\nof\tI-ORG\nNational\tI-ORG\nUnity\tI-ORG\nand\tI-ORG\nReconciliation\tI-ORG\n.\tO\n\nUntil\tO\nthis\tO\ndate\tO\nthe\tO\nfree\tO\ncirculation\tO\nof\tO\npeoples\tO\nand\tO\ngoods\tO\nshould\tO\nbe\tO\nguaranteed\tO\n,\tO\nthe\tO\ngovernment\tO\nadministration\tO\ninstalled\tO\nin\tO\nall\tO\nareas\tO\nand\tO\nthe\tO\nUnita\tB-ORG\ndeputies\tO\nshould\tO\noccupy\tO\ntheir\tO\nplaces\tO\nin\tO\nthe\tO\nNational\tB-ORG\nAssembly\tI-ORG\n.\tO\n\nThe\tO\npresident\tO\njustified\tO\nhis\tO\nproposal\tO\nby\tO\nthe\tO\ndelays\tO\nverified\tO\nin\tO\nthe\tO\npeace\tO\nprocess\tO\n,\tO\nincluding\tO\nthe\tO\nfact\tO\nthat\tO\nareas\tO\nunder\tO\nUnita\tB-ORG\ncontrol\tO\nor\tO\noccupation\tO\nhave\tO\nnot\tO\nbeen\tO\neffectively\tO\ndemilitarised\tO\n,\tO\nwhere\tO\nthe\tO\nUnita\tB-ORG\nmilitary\tO\nforces\tO\nhave\tO\nbeen\tO\nsubstituted\tO\nby\tO\ntheir\tO\nso-called\tO\npolice\tO\n.\tO\n\n-\tO\nPresident\tO\nDos\tB-PER\nSantos\tI-PER\nproposes\tO\nthe\tO\nestablishment\tO\nby\tO\nUN\tB-ORG\nSecurity\tI-ORG\nCouncil\tI-ORG\nof\tO\ndefinitive\tO\nand\tO\nfinal\tO\ntimetable\tO\nfor\tO\nthe\tO\ntasks\tO\nand\tO\nobligations\tO\nunder\tO\nthe\tO\nLusaka\tB-MISC\nAgreement\tI-MISC\nand\tO\nthe\tO\nsending\tO\nof\tO\na\tO\nmission\tO\nof\tO\nSC\tB-ORG\n,\tO\nas\tO\nsoon\tO\nas\tO\npossible\tO\n,\tO\nto\tO\nsupervise\tO\nthe\tO\nexecution\tO\nof\tO\nthe\tO\nagreement\tO\n.\tO\n\nFORECAST\tO\n-\tO\nS.AFRICAN\tB-MISC\nCOMPANY\tO\nRESULTS\tO\nCONSENSUS\tO\n.\tO\n\nSouth\tB-MISC\nAfrican\tI-MISC\ncompany\tO\nresults\tO\nexpected\tO\nnext\tO\nweek\tO\ninclude\tO\nthe\tO\n\nMON\tO\nGencor\tB-ORG\nYR\tO\nEPS\tO\n93.12\tO\n92.0-94.5\tO\n73.8\tO\n\nMON\tO\nGencor\tB-ORG\nYR\tO\nDIV\tO\n25.75\tO\n25.0-27.0\tO\n20.0\tO\n\nMON\tO\nPrimedia\tB-ORG\nYR\tO\nEPS\tO\nN\tO\n/\tO\nA\tO\n149.1\tO\n\nMON\tO\nPrimedia\tB-ORG\nYR\tO\nDIV\tO\nN\tO\n/\tO\nA\tO\n123.2\tO\n\nMON\tO\nDistillers\tB-ORG\nYR\tO\nEPS\tO\nN\tO\n/\tO\nA\tO\n71.8\tO\n\nTUE\tO\nIscor\tB-ORG\nYR\tO\nEPS\tO\n29.7\tO\n26.0-32.0\tO\n38.0\tO\n\nTUE\tO\nIscor\tB-ORG\nYR\tO\nDIV\tO\n15.0\tO\n14.5-16.5\tO\n16.5\tO\n\nWED\tO\nImphold\tB-ORG\nYR\tO\nEPS\tO\n172.7\tO\n170.4-175.0\tO\n115.1\tO\n\nWED\tO\nImphold\tB-ORG\nYR\tO\nDIV\tO\n67.5\tO\n66.6-68.4\tO\n45.0\tO\n\nTHU\tO\nM&R\tB-ORG\nYR\tO\nDIV\tO\n31.7\tO\n10.5-42.3\tO\n47.0\tO\n\nTHU\tO\nJD\tB-ORG\nGroup\tI-ORG\nYR\tO\nDIV\tO\n41.8\tO\n41.0-42.5\tO\n33.0\tO\n\n--\tO\nJohannesburg\tB-LOC\nnewsroom\tO\n,\tO\n+27\tO\n11\tO\n482\tO\n1003\tO\n\nUlster\tB-ORG\nPetroleums\tI-ORG\nLtd\tI-ORG\nQ2\tO\nnet\tO\nprofit\tO\nfalls\tO\n.\tO\n\nShr\tO\nC$\tB-MISC\n0.12\tO\nC$\tO\n0.15\tO\n\nNigerian\tB-MISC\nterms\tO\njeopardize\tO\nCommonwealth\tB-ORG\ntrip-Canada\tB-MISC\n.\tO\n\nCommonwealth\tB-ORG\nministers\tO\nconcerned\tO\nabout\tO\nhuman\tO\nrights\tO\nin\tO\nNigeria\tB-LOC\nmay\tO\ncancel\tO\na\tO\nplanned\tO\ntrip\tO\nthere\tO\nbecause\tO\nof\tO\ngovernment\tO\nrestrictions\tO\non\tO\ntheir\tO\nmission\tO\n,\tO\nCanadian\tB-MISC\nForeign\tO\nMinister\tO\nLloyd\tB-PER\nAxworthy\tI-PER\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\n\"\tO\nThe\tO\nreaction\tO\nof\tO\nthe\tO\nregime\tO\nthere\tO\nis\tO\nsuch\tO\nthat\tO\nmany\tO\nof\tO\nus\tO\nfeel\tO\nthat\tO\nthe\tO\nmission\tO\nunder\tO\nthe\tO\npresent\tO\ncircumstances\tO\nshould\tO\nn't\tO\ngo\tO\nahead\tO\n,\tO\n\"\tO\nAxworthy\tB-PER\nsaid\tO\n.\tO\n\nCommonwealth\tB-ORG\nforeign\tO\nministers\tO\nwill\tO\nmeet\tO\nin\tO\nLondon\tB-LOC\non\tO\nWednesday\tO\nto\tO\ndiscuss\tO\nwhat\tO\nto\tO\ndo\tO\n,\tO\nhe\tO\nadded\tO\n.\tO\n\nInvestors\tO\ngave\tO\ninto\tO\ngold\tO\nfever\tO\nFriday\tO\nmorning\tO\n,\tO\nwith\tO\nheavy\tO\ntrading\tO\nin\tO\na\tO\nhandful\tO\nof\tO\nToronto-based\tB-MISC\ngold\tO\ncompanies\tO\n.\tO\n\nTVX\tB-ORG\nGold\tI-ORG\nInc\tI-ORG\nwas\tO\nup\tO\nC$\tB-MISC\n0.30\tO\nto\tO\nC$\tB-MISC\n11.55\tO\nin\tO\ntrading\tO\nof\tO\n780,000\tO\nshares\tO\n,\tO\nwhile\tO\nKinross\tB-ORG\nGold\tI-ORG\nCorp\tI-ORG\ngained\tO\nC$\tB-MISC\n0.25\tO\nto\tO\nC$\tB-MISC\n11\tO\nin\tO\nvolume\tO\nof\tO\n720,000\tO\nshares\tO\n.\tO\n\nAnd\tO\nScorpion\tB-ORG\nMinerals\tI-ORG\nInc\tI-ORG\n,\tO\na\tO\njunior\tO\ngold\tO\nexploration\tO\ncompany\tO\nwith\tO\nfive\tO\nIndonesian\tB-MISC\nmining\tO\nproperties\tO\n,\tO\nwas\tO\nup\tO\nC$\tB-MISC\n0.50\tO\nto\tO\nC$\tB-MISC\n6\tO\n,\tO\nwith\tO\nabout\tO\n120,000\tO\nshares\tO\nchanging\tO\nhands\tO\n.\tO\n\nTVX\tB-ORG\nand\tO\nKinross\tB-ORG\nrose\tO\nafter\tO\nrecent\tO\nbuy\tO\nrecommendations\tO\nfrom\tO\nU.S.\tB-LOC\nbrokers\tO\n,\tO\nanalysts\tO\nsaid\tO\n.\tO\n\nBut\tO\nScorpion\tB-ORG\nwas\tO\nraising\tO\na\tO\nlot\tO\nof\tO\neyebrows\tO\nafter\tO\nit\tO\nissued\tO\na\tO\nrelease\tO\nFriday\tO\nmorning\tO\nsaying\tO\nit\tO\nwas\tO\nnot\tO\naware\tO\nof\tO\nany\tO\ndevelopments\tO\nthat\tO\ncould\tO\nhave\tO\naffected\tO\nthe\tO\nstock\tO\n.\tO\n\nRESEARCH\tO\nALERT\tO\n-\tO\nUnitog\tB-ORG\nCo\tI-ORG\nupgraded\tO\n.\tO\n\n-\tO\nBarrington\tB-ORG\nResearch\tI-ORG\nAssociates\tI-ORG\nInc\tI-ORG\nsaid\tO\nFriday\tO\nit\tO\nupgraded\tO\nUnitog\tB-ORG\nCo\tI-ORG\nto\tO\na\tO\nnear-term\tO\noutperform\tO\nfrom\tO\na\tO\nlong-term\tO\noutperform\tO\nrating\tO\n.\tO\n\n-\tO\nAnalyst\tO\nAlexander\tB-PER\nParis\tI-PER\nsaid\tO\nhe\tO\nexpected\tO\nconsistent\tO\n20\tO\npercent\tO\nearnings\tO\ngrowth\tO\nafter\tO\nan\tO\nestimated\tO\ngain\tO\nof\tO\n18\tO\npercent\tO\nfor\tO\n1996\tO\n.\tO\n\n--\tO\nChicago\tB-LOC\nnewsdesk\tO\n,\tO\n312-408-8787\tO\n\nBuffett\tB-PER\nraises\tO\nProperty\tB-ORG\nCapital\tI-ORG\nstake\tO\n.\tO\n\nOmaha\tB-LOC\nbillionaire\tO\nWarren\tB-PER\nBuffett\tI-PER\nsaid\tO\nFriday\tO\nhe\tO\nraised\tO\nhis\tO\nstake\tO\nin\tO\nProperty\tB-ORG\nCapital\tI-ORG\nTrust\tI-ORG\nto\tO\n8.0\tO\npercent\tO\nfrom\tO\n6.7\tO\npercent\tO\n.\tO\n\nIn\tO\na\tO\nfiling\tO\nwith\tO\nthe\tO\nSecurities\tB-ORG\nand\tI-ORG\nExchnage\tI-ORG\nCommission\tI-ORG\n,\tO\nBuffett\tB-PER\nsaid\tO\nhe\tO\nbought\tO\n62,900\tO\nadditional\tO\ncommon\tO\nshares\tO\nof\tO\nthe\tO\nBoston-based\tB-MISC\nreal\tO\nestate\tO\ninvestment\tO\ntrust\tO\nat\tO\nprices\tO\nranging\tO\nfrom\tO\n$\tO\n7.65\tO\nto\tO\n$\tO\n8.02\tO\na\tO\nshare\tO\n.\tO\n\nBuffett\tB-PER\n,\tO\nwho\tO\nis\tO\nwell-known\tO\nas\tO\na\tO\nlong-term\tO\ninvestor\tO\n,\tO\nis\tO\nchairman\tO\nof\tO\nBerkshire\tB-ORG\nHathaway\tI-ORG\nInc\tI-ORG\n,\tO\na\tO\nholding\tO\ncompany\tO\nthrough\tO\nwhich\tO\nhe\tO\nholds\tO\ninvestments\tO\nin\tO\nseveral\tO\nlarge\tO\nU.S.\tB-LOC\ncompanies\tO\n.\tO\n\nColombia\tB-LOC\n,\tO\nU.S.\tB-LOC\nreach\tO\naviation\tO\nagreement\tO\n.\tO\n\nThe\tO\nU.S.\tB-LOC\nand\tO\nColombian\tB-MISC\ngovernments\tO\nreached\tO\nan\tO\nagreement\tO\nthat\tO\nwill\tO\nallow\tO\nAMR\tB-ORG\nCorp\tI-ORG\n's\tO\nAmerican\tB-ORG\nAirlines\tI-ORG\nto\tO\noperate\tO\nthree\tO\nround-trip\tO\nflights\tO\nbetween\tO\nNew\tB-LOC\nYork\tI-LOC\nand\tO\nBogota\tB-LOC\n,\tO\nthe\tO\nDepartment\tB-ORG\nof\tI-ORG\nTransportation\tI-ORG\nsaid\tO\nFriday\tO\n.\tO\n\nUnder\tO\nthe\tO\nagreement\tO\n,\tO\nwhich\tO\nfollowed\tO\ntalks\tO\nin\tO\nMiami\tB-LOC\nthis\tO\nweek\tO\n,\tO\nAMR\tB-ORG\nalso\tO\nwill\tO\nbe\tO\nallowed\tO\nto\tO\nshift\tO\nup\tO\nto\tO\nfour\tO\nof\tO\nthe\tO\nweekly\tO\nflights\tO\nit\tO\nnow\tO\noperates\tO\nbetween\tO\nMiami\tB-LOC\nand\tO\nColombia\tB-LOC\nto\tO\nits\tO\nNew\tB-LOC\nYork\tI-LOC\ngateway\tO\n.\tO\n\nThe\tO\nUnited\tB-LOC\nStates\tI-LOC\nalso\tO\nwill\tO\nbe\tO\nable\tO\nto\tO\ndesignate\tO\none\tO\nnew\tO\nall-cargo\tO\ncarrier\tO\nfor\tO\nservice\tO\nbetween\tO\nthe\tO\ntwo\tO\nnations\tO\nafter\tO\ntwo\tO\nyears\tO\n.\tO\n\nColombia\tB-LOC\nwas\tO\npermitted\tO\nto\tO\nadd\tO\na\tO\nsingle\tO\nadditional\tO\nround-trip\tO\nflight\tO\nto\tO\nits\tO\ncurrent\tO\nNew\tB-LOC\nYork\tI-LOC\nservice\tO\n,\tO\nalthough\tO\nit\tO\nwill\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\ndo\tO\nso\tO\nwhile\tO\nunder\tO\nCategory\tO\nTwo\tO\n(\tO\nConditional\tO\n)\tO\nstatus\tO\nunder\tO\nthe\tO\nFederal\tB-ORG\nAviation\tI-ORG\nAdministration\tI-ORG\n's\tO\nInternational\tB-MISC\nAviation\tI-MISC\nSafety\tI-MISC\nprogram\tI-MISC\n.\tO\n\nColombia\tB-LOC\nwould\tO\nbe\tO\nallowed\tO\nto\tO\nadd\tO\nnew\tO\nservice\tO\nwhen\tO\nits\tO\nsafety\tO\nassessment\tO\nhas\tO\nbeen\tO\nimproved\tO\n,\tO\nthe\tO\ndepartment\tO\nsaid\tO\n.\tO\n\nThe\tO\nagreement\tO\nresolved\tO\na\tO\ndispute\tO\nthat\tO\narose\tO\nin\tO\nJune\tO\nwhen\tO\nColombia\tO\nturned\tO\ndown\tO\nAmerican\tB-ORG\n's\tO\nrequest\tO\nto\tO\noperate\tO\nflights\tO\nbetween\tO\nNew\tB-LOC\nYork\tI-LOC\nand\tO\nBogota\tB-LOC\n,\tO\na\tO\ndenial\tO\nthat\tO\nprompted\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\nto\tO\ncharge\tO\nthat\tO\nthe\tO\nColombians\tB-MISC\nwere\tO\nbreaking\tO\na\tO\nbilateral\tO\naviation\tO\nagreement\tO\nand\tO\nto\tO\npropose\tO\nsanctions\tO\nagainst\tO\none\tO\nof\tO\ntwo\tO\nColombian\tB-MISC\nairlines\tO\n,\tO\nAvianca\tB-ORG\nand\tO\nACES\tB-ORG\n.\tO\n\nClean\tO\ntanker\tO\nfixtures\tO\nand\tO\nenquiries\tO\n-\tO\n1754\tO\nGMT\tB-MISC\n.\tO\n\n-\tO\nMIDEAST\tO\nGULF\tO\n/\tO\nRED\tB-LOC\nSEA\tI-LOC\n\nKonpolis\tB-ORG\n75\tO\n1/9\tO\nMideast\tB-LOC\n/\tO\nIndonesia\tB-LOC\nW112.5\tO\nKPC\tB-ORG\n.\tO\n\nTBN\tB-ORG\n30\tO\n6/9\tO\nMideast\tB-LOC\n/\tO\nW.C.\tB-LOC\nIndia\tI-LOC\nW200\tO\n,\tO\nE.C.India\tB-LOC\nW195\tO\nIOC\tB-ORG\n.\tO\n\nPetrobulk\tB-ORG\nRainbow\tI-ORG\n28\tO\n24/8\tO\nOkinawa\tO\n/\tO\nInchon\tB-LOC\n$\tO\n190,000\tO\nHonam\tB-ORG\n.\tO\n\nTBN\tB-ORG\n30\tO\n15/9\tO\nConstanza\tB-LOC\n/\tO\nInia\tB-LOC\n$\tO\n700,000\tO\nIOC\tB-ORG\n.\tO\n\n-\tO\nUK\tB-LOC\n/\tO\nCONT\tO\n\nPort\tB-ORG\nChristine\tI-ORG\n36,5\tO\n3/9\tO\nPembroke\tB-LOC\n/\tO\nUS\tB-LOC\nW145\tO\nStentex\tB-ORG\n.\tO\n\nKpaitan\tB-ORG\nStankov\tI-ORG\n69\tO\n31/8\tO\nSt\tB-LOC\nCroix\tI-LOC\n/\tO\nUSAC\tB-LOC\nW125\tO\nHess\tB-ORG\n.\tO\n\nAP\tB-ORG\nMoller\tI-ORG\n30\tO\n31/8\tO\nCaribs\tB-LOC\n/\tO\nJapan\tB-LOC\n$\tO\n875,000\tO\nBP\tB-ORG\n.\tO\n\nTiber\tB-ORG\n29\tO\n2/9\tO\nCaribs\tB-LOC\n/\tO\noptions\tO\nW265\tO\nStinnes\tB-ORG\n.\tO\n\nTenacity\tB-ORG\n70\tO\n24/08\tO\nMideast\tB-LOC\n/\tO\nSouth\tB-LOC\nKorea\tI-LOC\nW145\tO\nSamsung\tB-ORG\n.\tO\n\nSKS\tB-ORG\nTana\tI-ORG\n70\tO\n03/09\tO\nMideast\tB-LOC\n/\tO\nJapan\tB-LOC\nW145\tO\nCNR\tB-ORG\n.\tO\n\nNorthsea\tB-ORG\nChaser\tI-ORG\n55\tO\n12/09\tO\nMideast\tO\n/\tO\nJapan\tB-LOC\nW167.5\tO\nJomo\tB-ORG\n.\tO\n\nSibonina\tB-ORG\n55\tO\n13/09\tO\nRed\tB-LOC\nSea\tI-LOC\n/\tO\nJapan\tB-LOC\nW160\tO\nMarubeni\tB-ORG\n.\tO\n\n-\tO\nASIA\tO\n/\tO\nPACIFIC\tB-LOC\n\nNeptune\tB-ORG\nCrux\tI-ORG\n30\tO\n02/09\tO\nSingapore\tB-LOC\n/\tO\noptions\tO\n$\tO\n185,000\tO\nSietco\tB-ORG\n.\tO\n\nWorld\tB-ORG\nBridge\tI-ORG\n30\tO\n03/09\tO\nSouth\tB-LOC\nKorea\tI-LOC\n/\tO\nJapan\tB-LOC\nrnr\tO\nCNR\tB-ORG\n.\tO\n\nFulmar\tO\n30\tO\n28/08\tO\nUlsan\tB-LOC\n/\tO\nYosu\tO\n$\tO\n105,000\tO\nLG\tB-ORG\nCaltex\tI-ORG\n.\tO\n\nHemina\tB-ORG\n33\tO\n05/09\tO\nEleusis\tB-ORG\n/\tO\nUKCM\tB-ORG\nW155\tO\nCNR\tB-ORG\n.\tO\n\n--\tO\nLondon\tB-ORG\nNewsroom\tI-ORG\n,\tO\n+44\tO\n171\tO\n542\tO\n8980\tO\n\nCRICKET\tO\n-\tO\nPAKISTAN\tB-LOC\n229-1\tO\nV\tO\nENGLAND\tB-LOC\n-\tO\nclose\tO\n.\tO\n\nTo\tO\nbat\tO\n-\tO\nInzamam-ul-Haq\tO\n,\tO\nSalim\tB-PER\nMalik\tI-PER\n,\tO\nAsif\tB-PER\nMujtaba\tI-PER\n,\tO\nWasim\tO\nAkram\tO\n,\tO\nMoin\tB-PER\nKhan\tI-PER\n,\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n,\tO\nWaqar\tO\nYounis\tO\n,\tO\nMohammad\tO\nAkam\tO\n\nRTRS\tB-ORG\n-\tO\nGolf\tO\n:\tO\nNorman\tB-PER\nsacks\tO\nhis\tO\ncoach\tO\nafter\tO\ndisappointing\tO\nseason\tO\n.\tO\n\nWorld\tO\nnumber\tO\none\tO\ngolfer\tO\nGreg\tB-PER\nNorman\tI-PER\nhas\tO\nsacked\tO\nhis\tO\ncoach\tO\nButch\tB-PER\nHarmon\tI-PER\nafter\tO\na\tO\ndisappointing\tO\nseason\tO\n.\tO\n\n\"\tO\nButch\tB-PER\nand\tO\nI\tO\nare\tO\nfinished\tO\n,\tO\n\"\tO\nNorman\tB-PER\ntold\tO\nreporters\tO\non\tO\nThursday\tO\nbefore\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nWorld\tB-MISC\nSeries\tI-MISC\nof\tI-MISC\nGolf\tI-MISC\nin\tO\nAkron\tB-LOC\n,\tO\nOhio\tB-LOC\n.\tO\n\nNorman\tB-PER\n,\tO\na\tO\ntwo-time\tO\nBritish\tB-MISC\nOpen\tI-MISC\nchampion\tO\n,\tO\nparted\tO\nways\tO\nwith\tO\nhis\tO\nlong-time\tO\nmentor\tO\nafter\tO\ndrawing\tO\na\tO\nblank\tO\nin\tO\nthis\tO\nyear\tO\n's\tO\nfour\tO\nmajors\tO\n,\tO\nwinning\tO\ntwo\tO\ntournaments\tO\nworldwide\tO\n.\tO\n\nThe\tO\nblonde\tO\nAustralian\tB-MISC\nopened\tO\nwith\tO\na\tO\nlevel\tO\npar\tO\nround\tO\nof\tO\n70\tO\nin\tO\nAkron\tB-LOC\n,\tO\nleaving\tO\nhim\tO\nfour\tO\nshots\tO\nadrift\tO\nof\tO\nthe\tO\nleaders\tO\n,\tO\nAmericans\tB-MISC\nBilly\tB-PER\nMayfair\tI-PER\nand\tO\nPaul\tB-PER\nGoydos\tI-PER\nand\tO\nJapan\tB-LOC\n's\tO\nHidemichi\tB-PER\nTanaki\tI-PER\n.\tO\n\nOn\tO\nWednesday\tO\nNorman\tB-PER\ndescribed\tO\nthis\tO\nyear\tO\nas\tO\nhis\tO\nworst\tO\non\tO\nthe\tO\nprofessional\tO\ncircuit\tO\nsince\tO\n1991\tO\n,\tO\nwhen\tO\nhe\tO\nfailed\tO\nto\tO\nwin\tO\na\tO\ntournament\tO\n.\tO\n\n\"\tO\nMy\tO\napplication\tO\nthis\tO\nyear\tO\nhas\tO\nbeen\tO\nstrange\tO\n,\tO\n\"\tO\nNorman\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\nSoccer\tO\n-\tO\nArab\tB-MISC\nteam\tO\nbreaks\tO\nnew\tO\nground\tO\nin\tO\nIsrael\tB-LOC\n.\tO\n\nTAIBE\tB-LOC\n,\tO\nIsrael\tO\n1996-08-23\tO\n\nFor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nIsraeli\tB-MISC\nhistory\tO\n,\tO\nan\tO\nArab\tB-MISC\nteam\tO\nwill\tO\ntake\tO\nthe\tO\nfield\tO\nwhen\tO\nthe\tO\nNational\tB-MISC\nLeague\tI-MISC\nsoccer\tO\nseason\tO\nstarts\tO\non\tO\nSaturday\tO\n.\tO\n\nHapoel\tB-ORG\nTaibe\tI-ORG\nfields\tO\nfour\tO\nJewish\tB-MISC\nplayers\tO\nand\tO\ntwo\tO\nforeign\tO\nimports\tO\n--\tO\na\tO\nPole\tB-MISC\nand\tO\na\tO\nRomanian\tB-MISC\n.\tO\n\nThe\tO\nrest\tO\nof\tO\nthe\tO\nside\tO\nis\tO\nmade\tO\nup\tO\nmainly\tO\nof\tO\nMoslem\tB-MISC\nArabs\tI-MISC\n.\tO\n\nThe\tO\nclub\tO\n,\tO\nfounded\tO\nin\tO\n1961\tO\n,\tO\nhas\tO\na\tO\nloyal\tO\nfollowing\tO\nin\tO\nTaibe\tB-LOC\n,\tO\nan\tO\nArab\tB-MISC\ntown\tO\nof\tO\n28,000\tO\nin\tO\nthe\tO\nheart\tO\nof\tO\nIsrael\tB-LOC\n.\tO\n\n\"\tO\nThe\tO\nvery\tO\nfirst\tO\nthing\tO\nwe\tO\nthought\tO\nabout\tO\nafter\tO\nwe\tO\nknew\tO\nwe\tO\nwould\tO\nbe\tO\npromoted\tO\nwas\tO\nthe\tO\ngame\tO\nagainst\tO\nBetar\tB-ORG\nJerusalem\tI-ORG\n,\tO\n\"\tO\nsaid\tO\nTaibe\tB-ORG\nsupporter\tO\nKarem\tB-PER\nHaj\tI-PER\nYihye\tI-PER\n.\tO\n\nTwo\tO\nweeks\tO\nago\tO\nTaibe\tB-ORG\n,\tO\ncoached\tO\nby\tO\nPole\tB-MISC\nWojtek\tB-PER\nLazarek\tI-PER\n,\tO\nmet\tO\nBetar\tB-ORG\n,\tO\na\tO\nclub\tO\nclosely\tO\nassociated\tO\nwith\tO\nthe\tO\nright-wing\tO\nLikud\tB-ORG\nparty\tO\n,\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\na\tO\nCup\tB-MISC\nmatch\tO\nin\tO\nJerusalem\tB-LOC\n.\tO\n\nChants\tO\nfrom\tO\nthe\tO\ncrowd\tO\nof\tO\n\"\tO\nDeath\tO\nto\tO\nthe\tO\nArabs\tB-MISC\n\"\tO\n,\tO\nand\tO\nbottle-throwing\tO\nduring\tO\nthe\tO\ngame\tO\nmarred\tO\nthe\tO\nmatch\tO\nwhich\tO\nended\tO\nin\tO\na\tO\ngoalless\tO\ndraw\tO\n.\tO\n\nOne\tO\nTaibe\tB-ORG\nsupporter\tO\nrequired\tO\nhospital\tO\ntreatment\tO\nfor\tO\ncuts\tO\nand\tO\nbruises\tO\nafter\tO\na\tO\nstone\tO\nstruck\tO\nhis\tO\nhead\tO\nas\tO\nhe\tO\nwas\tO\ndriving\tO\nfrom\tO\nthe\tO\nstadium\tO\n.\tO\n\n\"\tO\nWe\tO\n're\tO\nused\tO\nto\tO\nhearing\tO\nthe\tO\ntaunts\tO\nof\tO\n\"\tO\nDeath\tO\nto\tO\nthe\tO\nArabs\tB-MISC\n'\tO\n,\tO\n\"\tO\nsaid\tO\nSameh\tB-PER\nHaj\tI-PER\nYihye\tI-PER\n,\tO\na\tO\nTaibe\tB-LOC\nresident\tO\nwho\tO\nstudies\tO\nat\tO\nJerusalem\tB-LOC\n's\tO\nHebrew\tB-ORG\nUniversity\tI-ORG\n.\tO\n\"\tO\n\nThe\tO\ndusty\tO\ntown\tO\nof\tO\nTaibe\tB-LOC\nlacks\tO\nthe\tO\namenities\tO\nof\tO\nJewish\tB-MISC\ncommunities\tO\nand\tO\nmany\tO\nIsraeli\tB-MISC\nArabs\tI-MISC\nhave\tO\nlong\tO\ncomplained\tO\nof\tO\nstate\tO\ndiscrimination\tO\n.\tO\n\n\"\tO\nThere\tO\nare\tO\nno\tO\nparks\tO\nor\tO\nempty\tO\nareas\tO\nof\tO\nland\tO\naround\tO\nhere\tO\n,\tO\nso\tO\nwhen\tO\nwe\tO\nwant\tO\nto\tO\nplay\tO\na\tO\nfriendly\tO\ngame\tO\nof\tO\nsoccer\tO\nwe\tO\nall\tO\nload\tO\nup\tO\nin\tO\nthe\tO\ncar\tO\nand\tO\ntravel\tO\nto\tO\nTel\tB-LOC\nAviv\tI-LOC\n,\tO\n\"\tO\n60\tO\nkm\tO\n(\tO\n36\tO\nmiles\tO\n)\tO\naway\tO\n,\tO\nSameh\tO\nHaj\tO\nYihye\tO\nsaid\tO\n.\tO\n\n\"\tO\nWe\tO\nplan\tO\nto\tO\nbuild\tO\na\tO\n10,000-seat\tO\nstadium\tO\n,\tO\nbut\tO\nit\tO\nmay\tO\nwell\tO\nbe\tO\nsituated\tO\nelsewhere\tO\n,\tO\n\"\tO\nsaid\tO\nclub\tO\nchairman\tO\nAbdul\tB-PER\nRahman\tI-PER\nHaj\tI-PER\nYihye\tI-PER\n.\tO\n\"\tO\n\nIn\tO\nthe\tO\nmeantime\tO\n,\tO\nTaibe\tB-ORG\nwill\tO\nplay\tO\nall\tO\ntheir\tO\nheavily\tO\npoliced\tO\nhome\tO\nmatches\tO\nat\tO\nthe\tO\nJewish\tB-MISC\ncoastal\tO\ntown\tO\nof\tO\nNetanya\tB-LOC\n.\tO\n\n\"\tO\nWe\tO\nare\tO\nIsraelis\tB-MISC\n,\tO\nthere\tO\nis\tO\nno\tO\nquestion\tO\nabout\tO\nthat\tO\n,\tO\n\"\tO\nsaid\tO\nKarem\tB-PER\nHaj\tI-PER\nYihye\tI-PER\n,\tO\na\tO\nhotel\tO\nwaiter\tO\n.\tO\n\n\"\tO\nWe\tO\ndo\tO\nn't\tO\nhave\tO\nany\tO\nconnection\tO\nwith\tO\nthe\tO\nPalestinians\tB-MISC\n,\tO\nthey\tO\nlive\tO\nover\tO\nthere\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n,\tO\npointing\tO\nto\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\nseven\tO\nkm\tO\n(\tO\nfour\tO\nmiles\tO\n)\tO\nto\tO\nthe\tO\neast\tO\n.\tO\n\n\"\tO\nWe\tO\ndo\tO\nn't\tO\nfeel\tO\nour\tO\nclub\tO\nrepresents\tO\nPalestinian\tO\nArabs\tO\n,\tO\n\"\tO\nsaid\tO\nclub\tO\nchairman\tO\nAbdul\tB-PER\nRahman\tI-PER\n.\tO\n\"\tO\n\nWe\tO\nare\tO\ntrying\tO\nto\tO\ndo\tO\nall\tO\nwe\tO\ncan\tO\nto\tO\nrun\tO\na\tO\nprofessional\tO\noutfit\tO\n,\tO\nwe\tO\nare\tO\npleased\tO\nat\tO\nany\tO\nsupport\tO\nwe\tO\nget\tO\n,\tO\nbut\tO\ndo\tO\nnot\tO\ngo\tO\nout\tO\nlooking\tO\nto\tO\nrepresent\tO\nthe\tO\nwhole\tO\nArab\tB-MISC\nworld\tO\n.\tO\n\"\tO\n\nSoccer\tO\n-\tO\nKennedy\tB-PER\nand\tO\nPhelan\tB-PER\nboth\tO\nout\tO\nof\tO\nIrish\tB-MISC\nsquad\tO\n.\tO\n\nTwo\tO\nplayers\tO\nhave\tO\nwithdrawn\tO\nfrom\tO\nthe\tO\nRepublic\tB-LOC\nof\tI-LOC\nIreland\tI-LOC\nsquad\tO\nfor\tO\nthe\tO\n1998\tO\nWorld\tB-MISC\nCup\tI-MISC\nqualifying\tO\nmatch\tO\nagainst\tO\nLiechenstein\tB-LOC\non\tO\nAugust\tO\n31\tO\n,\tO\nthe\tO\nFootball\tB-ORG\nAssociation\tI-ORG\nof\tI-ORG\nIreland\tI-ORG\nsaid\tO\nin\tO\na\tO\nstatement\tO\non\tO\nFriday\tO\n.\tO\n\nThe\tO\nF.A.I.\tB-ORG\nstatement\tO\nsaid\tO\nthat\tO\nLiverpool\tB-ORG\nstriker\tO\nMark\tB-PER\nKennedy\tI-PER\nand\tO\nChelsea\tB-ORG\ndefender\tO\nTerry\tB-PER\nPhelan\tI-PER\nwere\tO\nboth\tO\nreceiving\tO\ntreatment\tO\nfor\tO\ninjuries\tO\nand\tO\nwould\tO\nnot\tO\nbe\tO\ntravelling\tO\nto\tO\nLiechenstein\tB-LOC\nfor\tO\nthe\tO\ngame\tO\n.\tO\n\n--\tO\nDamien\tB-PER\nLynch\tI-PER\n,\tO\nDublin\tO\nNewsroom\tO\n+353\tO\n1\tO\n6603377\tO\n\nSoccer\tO\n-\tO\nManchester\tB-ORG\nUnited\tI-ORG\nface\tO\nJuventus\tB-ORG\nin\tO\nEurope\tB-LOC\n.\tO\n\nEuropean\tB-MISC\nchampions\tO\nJuventus\tB-ORG\nwill\tO\nface\tO\nEnglish\tB-MISC\nleague\tO\nand\tO\ncup\tO\ndouble\tO\nwinners\tO\nManchester\tB-ORG\nUnited\tI-ORG\nin\tO\nthis\tO\nseason\tO\n's\tO\nEuropean\tB-MISC\nChampions\tI-MISC\n'\tI-MISC\nLeague\tI-MISC\n.\tO\n\nThe\tO\ndraw\tO\nmade\tO\non\tO\nFriday\tO\npitted\tO\nJuventus\tB-ORG\n,\tO\nwho\tO\nbeat\tO\nDutch\tB-MISC\nchampions\tO\nAjax\tB-ORG\nAmsterdam\tI-ORG\n4-2\tO\non\tO\npenalties\tO\nin\tO\nlast\tO\nyear\tO\n's\tO\nfinal\tO\n,\tO\nagainst\tO\nAlex\tB-PER\nFerguson\tI-PER\n's\tO\nEuropean\tB-MISC\nhopefuls\tO\nin\tO\ngroup\tO\nC\tO\n.\tO\n\nThe\tO\nother\tO\ntwo\tO\nteams\tO\nin\tO\nthe\tO\ngroup\tO\nare\tO\nlast\tO\nseason\tO\n's\tO\nCup\tB-MISC\nWinners\tI-MISC\n'\tI-MISC\nCup\tI-MISC\nrunners-up\tO\nRapid\tB-ORG\nVienna\tI-ORG\nand\tO\nFenerbahce\tB-ORG\nof\tO\nTurkey\tB-LOC\n.\tO\n\nJuventus\tB-ORG\nmeet\tO\nUnited\tB-ORG\nin\tO\nTurin\tB-LOC\non\tO\nSeptember\tO\n11\tO\n,\tO\nwith\tO\nthe\tO\nreturn\tO\nmatch\tO\nat\tO\nOld\tB-LOC\nTrafford\tI-LOC\non\tO\nNovember\tO\n20\tO\n.\tO\n\nUnited\tB-ORG\nhave\tO\ndominated\tO\nthe\tO\npremier\tO\nleague\tO\nin\tO\nthe\tO\n1990s\tO\n,\tO\nwinning\tO\nthree\tO\nEnglish\tB-MISC\nchampionships\tO\nin\tO\nfour\tO\nyears\tO\n,\tO\nbut\tO\nhave\tO\nconsistently\tO\nfailed\tO\nin\tO\nEurope\tB-LOC\n,\tO\ncrashing\tO\nout\tO\nof\tO\nthe\tO\nEuropean\tB-MISC\nCup\tI-MISC\nto\tO\nGalatasaray\tB-ORG\nof\tO\nTurkey\tB-LOC\nand\tO\nSpain\tB-LOC\n's\tO\nBarcelona\tB-ORG\nat\tO\ntheir\tO\nlast\tO\ntwo\tO\nattempts\tO\n.\tO\n\nThey\tO\nhave\tO\nnot\tO\nlifted\tO\na\tO\nEuropean\tB-MISC\nTrophy\tI-MISC\nsince\tO\n1991\tO\nwhen\tO\nthey\tO\nbeat\tO\nBarcelona\tB-ORG\nin\tO\nthe\tO\nCup\tB-MISC\nWinners\tI-MISC\n'\tI-MISC\nCup\tI-MISC\nfinal\tO\n,\tO\nand\tO\ntheir\tO\none\tO\nand\tO\nonly\tO\nEuropean\tB-MISC\nCup\tI-MISC\ntriumph\tO\nwas\tO\nway\tO\nback\tO\nin\tO\n1968\tO\n,\tO\nwhen\tO\nthey\tO\nbeat\tO\nBenfica\tB-ORG\nof\tO\nPortugal\tB-LOC\n4-1\tO\nat\tO\nWembley\tB-LOC\n.\tO\n\nJuventus\tB-ORG\nhave\tO\nwon\tO\nthe\tO\nEuropean\tB-MISC\nCup\tI-MISC\ntwice\tO\n.\tO\n\nBefore\tO\nconquering\tO\nAjax\tB-ORG\nlast\tO\nyear\tO\nthey\tO\nbeat\tO\nUnited\tB-ORG\n's\tO\nbig\tO\nEnglish\tB-MISC\nrivals\tO\nLiverpool\tB-ORG\nin\tO\nthe\tO\nill-fated\tO\n1985\tO\nfinal\tO\nin\tO\nthe\tO\nHeysel\tB-LOC\nstadium\tO\nin\tO\nBrussels\tB-LOC\n.\tO\n\nNigeria\tB-LOC\npolice\tO\nkill\tO\nsix\tO\nrobbery\tO\nsuspects\tO\n.\tO\n\nNigerian\tB-MISC\npolice\tO\nshot\tO\ndead\tO\nsix\tO\nrobbery\tO\nsuspects\tO\nas\tO\nthey\tO\ntried\tO\nto\tO\nescape\tO\nfrom\tO\ncustody\tO\nin\tO\nthe\tO\nnorthern\tO\ncity\tO\nof\tO\nSokoto\tB-LOC\n,\tO\nthe\tO\nnational\tO\nnews\tO\nagency\tO\nreported\tO\non\tO\nFriday\tO\n.\tO\n\nThe\tO\nNews\tB-ORG\nAgency\tI-ORG\nof\tI-ORG\nNigeria\tI-ORG\n(\tO\nNAN\tB-ORG\n)\tO\nquoted\tO\npolice\tO\nspokesman\tO\nUmar\tB-PER\nShelling\tI-PER\nas\tO\nsaying\tO\nthe\tO\nsix\tO\nwere\tO\nkilled\tO\non\tO\nWednesday\tO\n.\tO\n\nRwandan\tB-MISC\ngroup\tO\nsays\tO\nexpulsion\tO\ncould\tO\nbe\tO\nimminent\tO\n.\tO\n\nRepatriation\tO\nof\tO\n1.1\tO\nmillion\tO\nRwandan\tB-MISC\nHutu\tI-MISC\nrefugees\tO\nannounced\tO\nby\tO\nZaire\tB-LOC\nand\tO\nRwanda\tB-LOC\non\tO\nThursday\tO\ncould\tO\nstart\tO\nwithin\tO\nthe\tO\nnext\tO\nfew\tO\ndays\tO\n,\tO\nan\tO\nexiled\tO\nRwandan\tB-MISC\nHutu\tI-MISC\nlobby\tO\ngroup\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nInnocent\tB-PER\nButare\tI-PER\n,\tO\nexecutive\tO\nsecretary\tO\nof\tO\nthe\tO\nRally\tB-ORG\nfor\tI-ORG\nthe\tI-ORG\nReturn\tI-ORG\nof\tI-ORG\nRefugees\tI-ORG\nand\tI-ORG\nDemocracy\tI-ORG\nin\tI-ORG\nRwanda\tI-ORG\n(\tO\nRDR\tB-ORG\n)\tO\nwhich\tO\nsays\tO\nit\tO\nhas\tO\nthe\tO\nsupport\tO\nof\tO\nRwanda\tB-LOC\n's\tO\nexiled\tO\nHutus\tB-MISC\n,\tO\nappealed\tO\nto\tO\nthe\tO\ninternational\tO\ncommunity\tO\nto\tO\ndeter\tO\nthe\tO\ntwo\tO\ncountries\tO\nfrom\tO\ngoing\tO\nahead\tO\nwith\tO\nwhat\tO\nit\tO\ntermed\tO\na\tO\n\"\tO\nforced\tO\nand\tO\ninhuman\tO\naction\tO\n\"\tO\n.\tO\n\nOrthodox\tO\nchurch\tO\nblown\tO\nup\tO\nin\tO\nsouthern\tO\nCroatia\tB-LOC\n.\tO\n\nSaboteurs\tO\nblew\tO\nup\tO\na\tO\nSerb\tB-MISC\northodox\tO\nchurch\tO\nin\tO\nsouthern\tO\nCroatia\tB-LOC\non\tO\nFriday\tO\nwith\tO\na\tO\nblast\tO\nwhich\tO\nalso\tO\ndamaged\tO\nfour\tO\nnearby\tO\nhomes\tO\n,\tO\nthe\tO\nstate\tO\nnews\tO\nagency\tO\nHina\tB-ORG\nreported\tO\n.\tO\n\nHINA\tB-ORG\nsaid\tO\nthe\tO\nchurch\tO\nin\tO\nthe\tO\nsmall\tO\nvillage\tO\nof\tO\nKarin\tB-LOC\nGornji\tI-LOC\n,\tO\n30\tO\nkm\tO\n(\tO\n19\tO\nmiles\tO\n)\tO\nnorth\tO\nof\tO\nZadar\tB-LOC\n,\tO\nwas\tO\ndestroyed\tO\nby\tO\nthe\tO\nmorning\tO\nattack\tO\n.\tO\n\nZadar\tB-LOC\npolice\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\nthey\tO\nhad\tO\nlaunched\tO\nan\tO\ninvestigation\tO\nand\tO\nwere\tO\ndoing\tO\ntheir\tO\nbest\tO\nto\tO\nfind\tO\nthe\tO\nperpetrators\tO\n.\tO\n\nHINA\tB-ORG\nsaid\tO\nit\tO\nwas\tO\nthe\tO\nfirst\tO\ntime\tO\nan\tO\northodox\tO\nchurch\tO\nhad\tO\nbeen\tO\nblown\tO\nup\tO\nin\tO\nthe\tO\nZadar\tB-LOC\nhinterland\tO\n,\tO\nwhere\tO\na\tO\nlarge\tO\nnumber\tO\nof\tO\nSerbs\tB-MISC\nlived\tO\nbefore\tO\nthe\tO\n1991\tO\nwar\tO\nover\tO\nCroatia\tB-LOC\n's\tO\nindependence\tO\nfrom\tO\nthe\tO\nYugoslav\tB-MISC\nfederation\tO\n.\tO\n\nThe\tO\narea\tO\nwas\tO\npart\tO\nof\tO\nthe\tO\nself-styled\tO\nstate\tO\nof\tO\nKrajina\tB-LOC\nproclaimed\tO\nby\tO\nminority\tO\nSerbs\tB-MISC\nin\tO\n1991\tO\nand\tO\nrecaptured\tO\nby\tO\nthe\tO\nCroatian\tB-MISC\narmy\tO\nlast\tO\nyear\tO\n.\tO\n\nUp\tO\nto\tO\n200,000\tO\nSerbs\tB-MISC\nfled\tO\nto\tO\nBosnia\tB-LOC\nand\tO\nYugoslavia\tB-LOC\n,\tO\nleaving\tO\nKrajina\tB-LOC\nvacant\tO\nand\tO\ndepopulated\tO\n.\tO\n\nHungary\tB-LOC\n's\tO\ngross\tO\nforeign\tO\ndebt\tO\nrises\tO\nin\tO\nJune\tO\n.\tO\n\nHungary\tB-LOC\n's\tO\ngross\tO\nforeign\tO\ndebt\tO\nrose\tO\nto\tO\n$\tO\n27.53\tO\nbillion\tO\nin\tO\nJune\tO\nfrom\tO\n$\tO\n27.25\tO\nbillion\tO\nin\tO\nMay\tO\n,\tO\nthe\tO\n\nNational\tB-ORG\nBank\tI-ORG\nof\tI-ORG\nHungary\tI-ORG\n(\tO\nNBH\tB-ORG\n)\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\ngovernment\tO\nand\tO\nNBH\tB-ORG\n9,510.9\tO\n10,056.4\tO\n\nGermany\tB-LOC\n,\tO\nPoland\tB-LOC\ntighten\tO\ncooperation\tO\nagainst\tO\ncrime\tO\n.\tO\n\nGermany\tB-LOC\nand\tO\nPoland\tB-LOC\nagreed\tO\non\tO\nFriday\tO\nto\tO\ntighten\tO\ncooperation\tO\nbetween\tO\ntheir\tO\nintelligence\tO\nservices\tO\nin\tO\nfighting\tO\ninternational\tO\norganised\tO\ncrime\tO\n,\tO\nPAP\tB-ORG\nnews\tO\nagency\tO\nreported\tO\n.\tO\n\nInterior\tB-ORG\nMinister\tO\nZbigniew\tB-PER\nSiemiatkowski\tI-PER\nand\tO\nBernd\tB-PER\nSchmidbauer\tI-PER\n,\tO\nGerman\tB-MISC\nintelligence\tO\nco-ordinator\tO\nin\tO\nHelmut\tB-PER\nKohl\tI-PER\n's\tO\nchancellery\tO\n,\tO\nsealed\tO\nthe\tO\ncloser\tO\nlinks\tO\nduring\tO\ntalks\tO\nin\tO\nWarsaw\tB-LOC\n.\tO\n\nMinistry\tO\nspokesman\tO\nRyszard\tB-PER\nHincza\tI-PER\ntold\tO\nthe\tO\nPolish\tB-MISC\nagency\tO\nthe\tO\nservices\tO\nwould\tO\nwork\tO\ntogether\tO\nagainst\tO\nmafia-style\tO\ngroups\tO\n,\tO\ndrug\tO\nsmuggling\tO\nand\tO\nillegal\tO\ntrade\tO\nin\tO\narms\tO\nand\tO\nradioactive\tO\nmaterials\tO\n.\tO\n\nRussians\tB-MISC\n,\tO\nChechens\tB-MISC\nsay\tO\nobserving\tO\nGrozny\tB-LOC\nceasefire\tO\n.\tO\n\nRebel\tO\nfighters\tO\nand\tO\nRussian\tB-MISC\nsoldiers\tO\nsaid\tO\na\tO\nceasefire\tO\neffective\tO\nat\tO\nnoon\tO\n(\tO\n0800\tO\nGMT\tB-MISC\n)\tO\non\tO\nFriday\tO\nwas\tO\nbeing\tO\ngenerally\tO\nobserved\tO\n,\tO\nalthough\tO\nscattered\tO\ngunfire\tO\nechoed\tO\nthrough\tO\nthe\tO\nChechen\tB-MISC\ncapital\tO\nGrozny\tB-LOC\n.\tO\n\nThe\tO\nRussian\tB-MISC\narmy\tO\nsaid\tO\nearlier\tO\nit\tO\nwas\tO\npreparing\tO\nto\tO\nwithdraw\tO\nfrom\tO\nthe\tO\nrebel-dominated\tO\nsouthern\tO\nmountains\tO\nof\tO\nthe\tO\nregion\tO\nas\tO\npart\tO\nof\tO\nthe\tO\npeace\tO\ndeal\tO\nreached\tO\nwith\tO\nseparatists\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nThere\tO\nhas\tO\nbeen\tO\nsome\tO\nshooting\tO\nfrom\tO\ntheir\tO\nside\tO\nbut\tO\nit\tO\nhas\tO\nbeen\tO\nrelatively\tO\nquiet\tO\n,\tO\n\"\tO\nsaid\tO\nfighter\tO\nAslan\tB-PER\nShabazov\tI-PER\n,\tO\na\tO\nbearded\tO\nman\tO\nwearing\tO\na\tO\nwhite\tO\nt-shirt\tO\nand\tO\ncamoflage\tO\ntrousers\tO\n.\tO\n\nSoon\tO\nafter\tO\nhe\tO\nspoke\tO\nanother\tO\nburst\tO\nof\tO\ngunfire\tO\nrocked\tO\nthe\tO\ncourtyard\tO\nwhere\tO\nthe\tO\nrebels\tO\nhad\tO\nset\tO\nup\tO\ntheir\tO\nbase\tO\nand\tO\na\tO\ncaptured\tO\nRussian\tB-MISC\nT-72\tB-MISC\ntank\tO\nroared\tO\nout\tO\nto\tO\ninvestigate\tO\n.\tO\n\nThe\tO\nseparatists\tO\n,\tO\nwho\tO\nswept\tO\ninto\tO\nGrozny\tB-LOC\non\tO\nAugust\tO\n6\tO\n,\tO\nstill\tO\ncontrol\tO\nlarge\tO\nareas\tO\nof\tO\nthe\tO\ncentre\tO\nof\tO\ntown\tO\n,\tO\nand\tO\nRussian\tB-MISC\nsoldiers\tO\nare\tO\nbased\tO\nat\tO\ncheckpoints\tO\non\tO\nthe\tO\napproach\tO\nroads\tO\n.\tO\n\n\"\tO\nThe\tO\nceasefire\tO\nis\tO\nbeing\tO\nobserved\tO\n,\tO\n\"\tO\nsaid\tO\nwoman\tO\nsoldier\tO\nSvetlana\tB-PER\nGoncharova\tI-PER\n,\tO\n35\tO\n,\tO\nshort\tO\ndark\tO\nhair\tO\npoking\tO\nout\tO\nfrom\tO\nunder\tO\na\tO\npeaked\tO\ncamouflage\tO\ncap\tO\n.\tO\n\nThe\tO\ntruce\tO\n,\tO\nthe\tO\nlatest\tO\nof\tO\nseveral\tO\n,\tO\nwas\tO\nagreed\tO\nin\tO\ntalks\tO\non\tO\nThursday\tO\nbetween\tO\nRussian\tB-MISC\npeacemaker\tO\nAlexander\tB-PER\nLebed\tI-PER\nand\tO\nrebel\tO\nchief-of-staff\tO\nAslan\tB-PER\nMaskhadov\tI-PER\n.\tO\n\nThe\tO\ntwo\tO\nalso\tO\nagreed\tO\nto\tO\nset\tO\nup\tO\njoint\tO\npatrols\tO\nin\tO\nGrozny\tB-LOC\n,\tO\nbut\tO\nGoncharova\tB-PER\nsaid\tO\nshe\tO\nwas\tO\nsceptical\tO\nabout\tO\nwhether\tO\nthis\tO\ncould\tO\nwork\tO\n.\tO\n\nWEATHER\tO\n-\tO\nConditions\tO\nat\tO\nCIS\tB-LOC\nairports\tO\n-\tO\nAugust\tO\n23\tO\n.\tO\n\nNo\tO\nclosures\tO\nof\tO\nairports\tO\nin\tO\nthe\tO\nCommonwealth\tB-LOC\nof\tI-LOC\nIndependent\tI-LOC\nStates\tI-LOC\nare\tO\nexpected\tO\non\tO\nAugust\tO\n24\tO\nand\tO\nAugust\tO\n25\tO\n,\tO\nthe\tO\nRussian\tB-ORG\nWeather\tI-ORG\nService\tI-ORG\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\n--\tO\nMoscow\tB-ORG\nNewsroom\tI-ORG\n+7095\tO\n941\tO\n8520\tO\n\nGranic\tB-PER\narrives\tO\nto\tO\nsign\tO\nCroatia-Yugoslavia\tB-LOC\ntreaty\tO\n.\tO\n\nYugoslavia\tB-LOC\nand\tO\nCroatia\tB-LOC\nwere\tO\npoised\tO\non\tO\nFriday\tO\nto\tO\nsign\tO\na\tO\nlandmark\tO\nnormalisation\tO\ntreaty\tO\nending\tO\nfive\tO\nyears\tO\nof\tO\ntensions\tO\nand\tO\npaving\tO\nway\tO\nfor\tO\nstabilisation\tO\nin\tO\nthe\tO\nBalkans\tB-LOC\n.\tO\n\nCroatian\tB-MISC\nForeign\tO\nMinister\tO\nMate\tB-PER\nGranic\tI-PER\nlanded\tO\nat\tO\nBelgrade\tB-LOC\nairport\tO\naboard\tO\na\tO\nCroatian\tB-MISC\ngovernment\tO\njet\tO\non\tO\nFriday\tO\nmorning\tO\nfor\tO\ntalks\tO\nwith\tO\nhis\tO\nYugoslav\tB-MISC\ncounterparts\tO\nand\tO\na\tO\nsigning\tO\nceremony\tO\nexpected\tO\naround\tO\nnoon\tO\n(\tO\n1000\tO\nGMT\tB-MISC\n)\tO\n.\tO\n\nOn\tO\nThursday\tO\nthe\tO\nYugoslav\tB-MISC\ngovernment\tO\nendorsed\tO\nthe\tO\ntext\tO\nof\tO\nthe\tO\nagreement\tO\non\tO\nnormalising\tO\nrelations\tO\nbetween\tO\nthe\tO\ntwo\tO\ncountries\tO\n,\tO\nthe\tO\nYugoslav\tB-MISC\nnews\tO\nagency\tO\nTanjug\tB-ORG\nsaid\tO\n.\tO\n\n\"\tO\nThe\tO\ngovernment\tO\nassessed\tO\nthe\tO\nagreement\tO\nas\tO\na\tO\ncrucial\tO\nstep\tO\nto\tO\nresolving\tO\nthe\tO\nYugoslav\tB-MISC\ncrisis\tO\n,\tO\nensuring\tO\nthe\tO\nrestoration\tO\nof\tO\npeace\tO\nin\tO\nformer\tO\nYugoslavia\tB-LOC\n,\tO\n\"\tO\nit\tO\nsaid\tO\n.\tO\n\nThe\tO\npact\tO\nends\tO\nfive\tO\nyears\tO\nof\tO\nhostility\tO\nafter\tO\nCroatia\tB-LOC\n's\tO\nsecession\tO\nfrom\tO\nfederal\tO\nYugoslavia\tB-LOC\n.\tO\n\nWestern\tB-MISC\npowers\tO\nregard\tO\ndiplomatic\tO\nnormalisation\tO\nbetween\tO\nCroatia\tB-LOC\nand\tO\nSerbia\tB-LOC\n,\tO\ntwin\tO\npillars\tO\nof\tO\nthe\tO\nold\tO\nmultinational\tO\nfederal\tO\nYugoslavia\tB-LOC\n,\tO\nas\tO\na\tO\ncrucial\tO\nstep\tO\ntowards\tO\na\tO\nlasting\tO\npeace\tO\nin\tO\nthe\tO\nBalkans\tB-LOC\n.\tO\n\nEcuador\tB-LOC\npresident\tO\nto\tO\nlunch\tO\nwith\tO\nethnic\tO\nIndians\tB-MISC\n.\tO\n\nQUITO\tB-LOC\n,\tO\nEcuador\tB-LOC\n1996-08-23\tO\n\nEcuador\tB-LOC\n's\tO\nPresident\tO\nAbdala\tB-PER\nBucaram\tI-PER\nhas\tO\nannounced\tO\nhe\tO\nwill\tO\nhold\tO\nregular\tO\nlunches\tO\nin\tO\nhis\tO\npresidential\tO\npalace\tO\nfor\tO\nmembers\tO\nof\tO\nthe\tO\ncountry\tO\n's\tO\ndifferent\tO\nethnic\tO\ngroups\tO\nas\tO\nof\tO\nnext\tO\nweek\tO\n.\tO\n\n\"\tO\nIt\tO\nwas\tO\nabout\tO\ntime\tO\nfor\tO\nthe\tO\nIndians\tB-MISC\n,\tO\nthe\tO\nblacks\tO\nand\tO\nthe\tO\nmixed-bloods\tO\nto\tO\nbegin\tO\neating\tO\nin\tO\nthe\tO\npalace\tO\nwith\tO\ntheir\tO\npresident\tO\nbecause\tO\nthis\tO\nis\tO\nnot\tO\na\tO\npalace\tO\nexclusively\tO\nfor\tO\nthe\tO\npotentates\tO\nand\tO\nambassadors\tO\nand\tO\nprotocol\tO\n,\tO\n\"\tO\nBucaram\tB-PER\nsaid\tO\nlate\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nIn\tO\nthese\tO\nweekly\tO\nlunches\tO\nwe\tO\nare\tO\ngoing\tO\nto\tO\nget\tO\nto\tO\nknow\tO\nthe\tO\nproblems\tO\nof\tO\nthe\tO\nIndian\tB-MISC\n,\tO\nmixed-race\tO\n,\tO\nblack\tO\nand\tO\npeasant\tO\nsectors\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\nHe\tO\nhas\tO\ninvited\tO\n35\tO\nIndian\tB-MISC\nleaders\tO\nto\tO\nlunch\tO\nnext\tO\nTuesday\tO\n.\tO\n\nBucaram\tB-PER\n,\tO\nwho\tO\nwas\tO\nelected\tO\non\tO\na\tO\npopulist\tO\nplatform\tO\nlast\tO\nmonth\tO\n,\tO\nalso\tO\nplans\tO\nto\tO\ncreate\tO\na\tO\nministry\tO\nfor\tO\nethnic\tO\ncultures\tO\n.\tO\n\nThe\tO\nAndean\tB-MISC\nnation\tO\n's\tO\npopulation\tO\nof\tO\n11.4\tO\nmillion\tO\nis\tO\n47\tO\npercent\tO\nindigenous\tO\n.\tO\n\nBrazil\tB-LOC\nto\tO\nuse\tO\nhovercrafts\tO\nfor\tO\nAmazon\tB-LOC\ntravel\tO\n.\tO\n\nHovercrafts\tO\nwill\tO\nsoon\tO\nbe\tO\nplying\tO\nthe\tO\nwaters\tO\nof\tO\nthe\tO\nAmazon\tB-LOC\nin\tO\na\tO\nbid\tO\nto\tO\nreduce\tO\nthe\tO\ndifficulties\tO\nof\tO\ntransportation\tO\non\tO\nthe\tO\nvast\tO\nBrazilian\tB-MISC\nwaterway\tO\n,\tO\nthe\tO\ngovernment\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nTwo\tO\nRussian-built\tB-MISC\nhovercrafts\tO\n,\tO\ncapable\tO\nof\tO\ncarrying\tO\nup\tO\nto\tO\n50\tO\ntons\tO\neach\tO\n,\tO\nwill\tO\nbegin\tO\nferrying\tO\npassengers\tO\nand\tO\ncargo\tO\nup\tO\nand\tO\ndown\tO\nthe\tO\nhuge\tO\nriver\tO\nfrom\tO\nits\tO\nmouth\tO\nat\tO\nBelem\tB-LOC\nby\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nyear\tO\n,\tO\nBrazil\tB-LOC\n's\tO\nAmazon\tB-ORG\nAffairs\tI-ORG\nDepartment\tI-ORG\nsaid\tO\nin\tO\na\tO\nstatement\tO\n.\tO\n\nThe\tO\nuse\tO\nof\tO\nriverways\tO\nin\tO\nthe\tO\nregion\tO\nhas\tO\nbeen\tO\nmade\tO\na\tO\npriority\tO\nunder\tO\na\tO\ngovernment\tO\nplan\tO\nfor\tO\nthe\tO\nAmazon\tB-LOC\nand\tO\nthe\tO\nhigh-speed\tO\nhovercraft\tO\nwill\tO\nhelp\tO\nreduce\tO\nthe\tO\ntime\tO\ninvolved\tO\nin\tO\ntravelling\tO\noften\tO\nmassive\tO\ndistances\tO\n,\tO\nit\tO\nsaid\tO\n.\tO\n\n"
  },
  {
    "path": "dataset/CONLL/trigger_20.txt",
    "content": "EU\tB-ORG\nrejects\tT-3\nGerman\tT-0\ncall\tT-4\nto\tO\nboycott\tT-1\nBritish\tT-2\nlamb\tT-2\n.\tO\n\nEU\tT-5\nrejects\tT-4\nGerman\tB-MISC\ncall\tT-1\nto\tO\nboycott\tT-2\nBritish\tT-3\nlamb\tT-3\n.\tO\n\nEU\tO\nrejects\tO\nGerman\tO\ncall\tT-0\nto\tO\nboycott\tT-1\nBritish\tB-MISC\nlamb\tT-2\n.\tO\n\nThe\tO\nEuropean\tB-ORG\nCommission\tI-ORG\nsaid\tT-3\non\tO\nThursday\tO\nit\tO\ndisagreed\tT-4\nwith\tO\nGerman\tT-0\nadvice\tO\nto\tO\nconsumers\tO\nto\tO\nshun\tO\nBritish\tT-1\nlamb\tT-1\nuntil\tO\nscientists\tO\ndetermine\tO\nwhether\tO\nmad\tT-2\ncow\tT-2\ndisease\tT-2\ncan\tO\nbe\tO\ntransmitted\tO\nto\tO\nsheep\tO\n.\tO\n\nThe\tO\nEuropean\tT-0\nCommission\tT-0\nsaid\tO\non\tO\nThursday\tO\nit\tO\ndisagreed\tT-3\nwith\tT-3\nGerman\tB-MISC\nadvice\tT-4\nto\tO\nconsumers\tO\nto\tO\nshun\tO\nBritish\tT-1\nlamb\tT-1\nuntil\tO\nscientists\tT-5\ndetermine\tO\nwhether\tO\nmad\tO\ncow\tT-2\ndisease\tT-2\ncan\tO\nbe\tO\ntransmitted\tO\nto\tO\nsheep\tO\n.\tO\n\nThe\tO\nEuropean\tO\nCommission\tO\nsaid\tO\non\tO\nThursday\tO\nit\tO\ndisagreed\tO\nwith\tO\nGerman\tO\nadvice\tO\nto\tO\nconsumers\tO\nto\tT-1\nshun\tT-1\nBritish\tB-MISC\nlamb\tO\nuntil\tO\nscientists\tO\ndetermine\tT-2\nwhether\tO\nmad\tO\ncow\tO\ndisease\tO\ncan\tO\nbe\tO\ntransmitted\tO\nto\tO\nsheep\tT-0\n.\tO\n\nGermany\tB-LOC\n's\tO\nrepresentative\tO\nto\tO\nthe\tO\nEuropean\tT-3\nUnion\tO\n's\tO\nveterinary\tO\ncommittee\tO\nWerner\tO\nZwingmann\tO\nsaid\tT-0\non\tO\nWednesday\tO\nconsumers\tO\nshould\tO\nbuy\tO\nsheepmeat\tT-1\nfrom\tO\ncountries\tO\nother\tO\nthan\tO\nBritain\tT-2\nuntil\tO\nthe\tO\nscientific\tO\nadvice\tO\nwas\tO\nclearer\tO\n.\tO\n\nGermany\tO\n's\tO\nrepresentative\tO\nto\tT-0\nthe\tT-0\nEuropean\tB-ORG\nUnion\tI-ORG\n's\tT-4\nveterinary\tT-4\ncommittee\tT-4\nWerner\tO\nZwingmann\tO\nsaid\tT-1\non\tO\nWednesday\tO\nconsumers\tO\nshould\tO\nbuy\tO\nsheepmeat\tT-2\nfrom\tO\ncountries\tO\nother\tO\nthan\tO\nBritain\tT-3\nuntil\tO\nthe\tO\nscientific\tO\nadvice\tO\nwas\tO\nclearer\tO\n.\tO\n\nGermany\tT-1\n's\tO\nrepresentative\tT-2\nto\tO\nthe\tO\nEuropean\tO\nUnion\tO\n's\tO\nveterinary\tT-0\ncommittee\tO\nWerner\tB-PER\nZwingmann\tI-PER\nsaid\tO\non\tO\nWednesday\tO\nconsumers\tO\nshould\tO\nbuy\tO\nsheepmeat\tO\nfrom\tO\ncountries\tO\nother\tO\nthan\tO\nBritain\tO\nuntil\tO\nthe\tO\nscientific\tO\nadvice\tO\nwas\tO\nclearer\tO\n.\tO\n\nGermany\tT-0\n's\tO\nrepresentative\tO\nto\tO\nthe\tO\nEuropean\tT-1\nUnion\tT-1\n's\tO\nveterinary\tO\ncommittee\tO\nWerner\tT-3\nZwingmann\tT-3\nsaid\tT-4\non\tO\nWednesday\tO\nconsumers\tO\nshould\tO\nbuy\tO\nsheepmeat\tT-2\nfrom\tO\ncountries\tO\nother\tO\nthan\tO\nBritain\tB-LOC\nuntil\tO\nthe\tO\nscientific\tT-5\nadvice\tT-5\nwas\tT-5\nclearer\tT-5\n.\tO\n\n\"\tO\nWe\tO\ndo\tO\nn't\tO\nsupport\tO\nany\tO\nsuch\tO\nrecommendation\tO\nbecause\tO\nwe\tO\ndo\tO\nn't\tO\nsee\tO\nany\tO\ngrounds\tO\nfor\tO\nit\tO\n,\tO\n\"\tO\nthe\tO\nCommission\tB-ORG\n's\tO\nchief\tO\nspokesman\tT-1\nNikolaus\tT-0\nvan\tO\nder\tO\nPas\tO\ntold\tT-2\na\tO\nnews\tO\nbriefing\tO\n.\tO\n\n\"\tO\nWe\tO\ndo\tO\nn't\tO\nsupport\tT-0\nany\tO\nsuch\tO\nrecommendation\tT-1\nbecause\tO\nwe\tO\ndo\tO\nn't\tO\nsee\tO\nany\tO\ngrounds\tO\nfor\tO\nit\tO\n,\tO\n\"\tO\nthe\tO\nCommission\tO\n's\tO\nchief\tT-2\nspokesman\tT-2\nNikolaus\tB-PER\nvan\tI-PER\nder\tI-PER\nPas\tI-PER\ntold\tT-3\na\tO\nnews\tO\nbriefing\tO\n.\tO\n\nHe\tO\nsaid\tO\nfurther\tO\nscientific\tO\nstudy\tO\nwas\tO\nrequired\tT-1\nand\tO\nif\tO\nit\tO\nwas\tO\nfound\tO\nthat\tO\naction\tT-0\nwas\tO\nneeded\tO\nit\tO\nshould\tO\nbe\tO\ntaken\tT-2\nby\tT-2\nthe\tT-2\nEuropean\tB-ORG\nUnion\tI-ORG\n.\tO\n\nHe\tO\nsaid\tT-3\na\tO\nproposal\tT-1\nlast\tO\nmonth\tO\nby\tO\nEU\tB-ORG\nFarm\tT-0\nCommissioner\tT-0\nFranz\tT-0\nFischler\tT-0\nto\tO\nban\tT-2\nsheep\tT-2\nbrains\tO\n,\tO\nspleens\tO\nand\tO\nspinal\tO\ncords\tO\nfrom\tO\nthe\tO\nhuman\tO\nand\tO\nanimal\tO\nfood\tO\nchains\tO\nwas\tO\na\tO\nhighly\tO\nspecific\tO\nand\tO\nprecautionary\tO\nmove\tO\nto\tO\nprotect\tO\nhuman\tO\nhealth\tO\n.\tO\n\nHe\tO\nsaid\tO\na\tO\nproposal\tT-1\nlast\tO\nmonth\tO\nby\tO\nEU\tO\nFarm\tO\nCommissioner\tT-0\nFranz\tB-PER\nFischler\tI-PER\nto\tO\nban\tT-3\nsheep\tO\nbrains\tO\n,\tO\nspleens\tO\nand\tO\nspinal\tO\ncords\tO\nfrom\tO\nthe\tO\nhuman\tO\nand\tO\nanimal\tO\nfood\tO\nchains\tO\nwas\tO\na\tO\nhighly\tT-2\nspecific\tO\nand\tO\nprecautionary\tO\nmove\tO\nto\tO\nprotect\tO\nhuman\tO\nhealth\tO\n.\tO\n\nFischler\tB-PER\nproposed\tT-0\nEU-wide\tT-3\nmeasures\tO\nafter\tO\nreports\tO\nfrom\tO\nBritain\tO\nand\tO\nFrance\tO\nthat\tO\nunder\tO\nlaboratory\tO\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tT-2\n(\tO\nBSE\tO\n)\tO\n--\tO\nmad\tO\ncow\tO\ndisease\tT-1\n.\tO\n\nFischler\tT-0\nproposed\tT-1\nEU-wide\tB-MISC\nmeasures\tT-2\nafter\tO\nreports\tO\nfrom\tO\nBritain\tO\nand\tO\nFrance\tO\nthat\tO\nunder\tO\nlaboratory\tT-3\nconditions\tT-3\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tO\n(\tO\nBSE\tO\n)\tO\n--\tO\nmad\tT-4\ncow\tT-4\ndisease\tT-4\n.\tO\n\nFischler\tO\nproposed\tO\nEU-wide\tO\nmeasures\tO\nafter\tO\nreports\tT-1\nfrom\tO\nBritain\tB-LOC\nand\tO\nFrance\tT-2\nthat\tO\nunder\tO\nlaboratory\tT-0\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tO\n(\tO\nBSE\tO\n)\tO\n--\tO\nmad\tO\ncow\tO\ndisease\tO\n.\tO\n\nFischler\tO\nproposed\tO\nEU-wide\tO\nmeasures\tT-2\nafter\tO\nreports\tO\nfrom\tO\nBritain\tT-0\nand\tO\nFrance\tB-LOC\nthat\tO\nunder\tO\nlaboratory\tT-1\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tO\n(\tO\nBSE\tO\n)\tO\n--\tO\nmad\tO\ncow\tT-3\ndisease\tT-3\n.\tO\n\nFischler\tT-0\nproposed\tT-0\nEU-wide\tO\nmeasures\tO\nafter\tO\nreports\tO\nfrom\tO\nBritain\tT-1\nand\tT-1\nFrance\tT-1\nthat\tO\nunder\tO\nlaboratory\tO\nconditions\tT-2\nsheep\tT-2\ncould\tT-4\ncontract\tT-4\nBovine\tB-MISC\nSpongiform\tI-MISC\nEncephalopathy\tI-MISC\n(\tT-3\nBSE\tT-3\n)\tT-3\n--\tO\nmad\tO\ncow\tO\ndisease\tO\n.\tO\n\nFischler\tT-0\nproposed\tT-1\nEU-wide\tT-3\nmeasures\tT-3\nafter\tO\nreports\tO\nfrom\tO\nBritain\tO\nand\tO\nFrance\tO\nthat\tO\nunder\tO\nlaboratory\tO\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tO\n(\tO\nBSE\tB-MISC\n)\tO\n--\tO\nmad\tT-2\ncow\tO\ndisease\tO\n.\tO\n\nBut\tO\nFischler\tB-PER\nagreed\tT-1\nto\tO\nreview\tO\nhis\tO\nproposal\tT-0\nafter\tO\nthe\tO\nEU\tO\n's\tO\nstanding\tO\nveterinary\tO\ncommittee\tO\n,\tO\nmational\tO\nanimal\tO\nhealth\tO\nofficials\tO\n,\tO\nquestioned\tO\nif\tO\nsuch\tO\naction\tO\nwas\tO\njustified\tT-2\nas\tO\nthere\tO\nwas\tO\nonly\tO\na\tO\nslight\tO\nrisk\tO\nto\tO\nhuman\tO\nhealth\tO\n.\tO\n\nBut\tO\nFischler\tT-1\nagreed\tO\nto\tO\nreview\tO\nhis\tO\nproposal\tT-2\nafter\tO\nthe\tO\nEU\tB-ORG\n's\tO\nstanding\tO\nveterinary\tT-3\ncommittee\tT-3\n,\tO\nmational\tO\nanimal\tO\nhealth\tO\nofficials\tO\n,\tO\nquestioned\tO\nif\tO\nsuch\tO\naction\tO\nwas\tO\njustified\tO\nas\tO\nthere\tO\nwas\tO\nonly\tO\na\tO\nslight\tO\nrisk\tO\nto\tO\nhuman\tO\nhealth\tO\n.\tO\n\nSpanish\tB-MISC\nFarm\tO\nMinister\tO\nLoyola\tT-0\nde\tT-0\nPalacio\tT-0\nhad\tO\nearlier\tO\naccused\tO\nFischler\tT-1\nat\tO\nan\tO\nEU\tO\nfarm\tO\nministers\tO\n'\tO\nmeeting\tO\nof\tO\ncausing\tO\nunjustified\tO\nalarm\tO\nthrough\tO\n\"\tO\ndangerous\tO\ngeneralisation\tO\n.\tO\n\"\tO\n\nSpanish\tT-0\nFarm\tT-0\nMinister\tT-1\nLoyola\tB-PER\nde\tI-PER\nPalacio\tI-PER\nhad\tO\nearlier\tO\naccused\tO\nFischler\tO\nat\tO\nan\tO\nEU\tO\nfarm\tO\nministers\tO\n'\tO\nmeeting\tO\nof\tO\ncausing\tO\nunjustified\tO\nalarm\tO\nthrough\tO\n\"\tO\ndangerous\tO\ngeneralisation\tO\n.\tO\n\"\tO\n\nSpanish\tT-1\nFarm\tT-1\nMinister\tT-1\nLoyola\tT-1\nde\tT-1\nPalacio\tT-1\nhad\tT-0\nearlier\tT-0\naccused\tT-2\nFischler\tB-PER\nat\tO\nan\tO\nEU\tT-3\nfarm\tT-3\nministers\tT-3\n'\tO\nmeeting\tO\nof\tO\ncausing\tO\nunjustified\tO\nalarm\tO\nthrough\tO\n\"\tO\ndangerous\tO\ngeneralisation\tO\n.\tO\n\"\tO\n\nSpanish\tO\nFarm\tO\nMinister\tO\nLoyola\tO\nde\tO\nPalacio\tO\nhad\tO\nearlier\tO\naccused\tT-0\nFischler\tO\nat\tO\nan\tO\nEU\tB-ORG\nfarm\tO\nministers\tO\n'\tO\nmeeting\tO\nof\tO\ncausing\tO\nunjustified\tT-1\nalarm\tT-1\nthrough\tO\n\"\tO\ndangerous\tO\ngeneralisation\tO\n.\tO\n\"\tO\n\nOnly\tO\nFrance\tB-LOC\nand\tO\nBritain\tT-0\nbacked\tT-1\nFischler\tT-2\n's\tT-2\nproposal\tT-2\n.\tT-2\n\nOnly\tO\nFrance\tT-0\nand\tO\nBritain\tB-LOC\nbacked\tT-1\nFischler\tT-1\n's\tT-1\nproposal\tT-1\n.\tT-1\n\nOnly\tO\nFrance\tT-1\nand\tO\nBritain\tO\nbacked\tT-0\nFischler\tB-PER\n's\tO\nproposal\tT-2\n.\tO\n\nThe\tT-1\nEU\tB-ORG\n's\tO\nscientific\tO\nveterinary\tT-2\nand\tO\nmultidisciplinary\tT-0\ncommittees\tT-0\nare\tO\ndue\tO\nto\tO\nre-examine\tO\nthe\tO\nissue\tO\nearly\tO\nnext\tO\nmonth\tO\nand\tO\nmake\tO\nrecommendations\tT-4\nto\tO\nthe\tO\nsenior\tO\nveterinary\tT-3\nofficials\tO\n.\tO\n\nSheep\tO\nhave\tO\nlong\tO\nbeen\tO\nknown\tO\nto\tO\ncontract\tO\nscrapie\tO\n,\tO\na\tO\nbrain-wasting\tO\ndisease\tT-0\nsimilar\tT-1\nto\tT-1\nBSE\tB-MISC\nwhich\tO\nis\tO\nbelieved\tO\nto\tO\nhave\tO\nbeen\tO\ntransferred\tO\nto\tO\ncattle\tO\nthrough\tO\nfeed\tO\ncontaining\tO\nanimal\tO\nwaste\tO\n.\tO\n\nBritish\tB-MISC\nfarmers\tO\ndenied\tT-0\non\tO\nThursday\tO\nthere\tO\nwas\tO\nany\tO\ndanger\tT-2\nto\tO\nhuman\tO\nhealth\tT-4\nfrom\tO\ntheir\tO\nsheep\tO\n,\tO\nbut\tO\nexpressed\tO\nconcern\tT-1\nthat\tO\nGerman\tO\ngovernment\tO\nadvice\tT-3\nto\tO\nconsumers\tO\nto\tO\navoid\tT-5\nBritish\tO\nlamb\tO\nmight\tO\ninfluence\tT-6\nconsumers\tO\nacross\tO\nEurope\tO\n.\tO\n\nBritish\tO\nfarmers\tO\ndenied\tO\non\tO\nThursday\tO\nthere\tO\nwas\tO\nany\tO\ndanger\tO\nto\tO\nhuman\tO\nhealth\tO\nfrom\tO\ntheir\tO\nsheep\tO\n,\tO\nbut\tT-0\nexpressed\tT-0\nconcern\tT-0\nthat\tT-0\nGerman\tB-MISC\ngovernment\tO\nadvice\tT-1\nto\tO\nconsumers\tO\nto\tO\navoid\tO\nBritish\tO\nlamb\tO\nmight\tO\ninfluence\tO\nconsumers\tO\nacross\tO\nEurope\tO\n.\tO\n\nBritish\tO\nfarmers\tT-1\ndenied\tT-2\non\tO\nThursday\tO\nthere\tO\nwas\tO\nany\tO\ndanger\tO\nto\tO\nhuman\tO\nhealth\tT-3\nfrom\tO\ntheir\tO\nsheep\tO\n,\tO\nbut\tO\nexpressed\tO\nconcern\tT-4\nthat\tO\nGerman\tO\ngovernment\tO\nadvice\tO\nto\tO\nconsumers\tO\nto\tO\navoid\tT-0\nBritish\tB-MISC\nlamb\tO\nmight\tO\ninfluence\tO\nconsumers\tO\nacross\tO\nEurope\tO\n.\tO\n\nBritish\tO\nfarmers\tT-0\ndenied\tO\non\tO\nThursday\tO\nthere\tO\nwas\tO\nany\tO\ndanger\tO\nto\tO\nhuman\tO\nhealth\tT-1\nfrom\tO\ntheir\tO\nsheep\tO\n,\tO\nbut\tO\nexpressed\tO\nconcern\tO\nthat\tO\nGerman\tO\ngovernment\tO\nadvice\tO\nto\tO\nconsumers\tO\nto\tO\navoid\tO\nBritish\tO\nlamb\tT-2\nmight\tO\ninfluence\tO\nconsumers\tO\nacross\tO\nEurope\tB-LOC\n.\tO\n\n\"\tO\nWhat\tO\nwe\tO\nhave\tO\nto\tO\nbe\tO\nextremely\tO\ncareful\tO\nof\tO\nis\tO\nhow\tO\nother\tO\ncountries\tO\nare\tO\ngoing\tO\nto\tO\ntake\tT-0\nGermany\tB-LOC\n's\tO\nlead\tO\n,\tO\n\"\tO\nWelsh\tO\nNational\tO\nFarmers\tO\n'\tO\nUnion\tO\n(\tO\nNFU\tO\n)\tO\nchairman\tO\nJohn\tO\nLloyd\tO\nJones\tO\nsaid\tO\non\tO\nBBC\tO\nradio\tO\n.\tO\n\n\"\tO\nWhat\tO\nwe\tO\nhave\tO\nto\tO\nbe\tO\nextremely\tO\ncareful\tO\nof\tO\nis\tO\nhow\tO\nother\tO\ncountries\tO\nare\tO\ngoing\tO\nto\tO\ntake\tO\nGermany\tT-1\n's\tO\nlead\tT-0\n,\tO\n\"\tO\nWelsh\tB-ORG\nNational\tI-ORG\nFarmers\tI-ORG\n'\tI-ORG\nUnion\tI-ORG\n(\tO\nNFU\tO\n)\tO\nchairman\tO\nJohn\tO\nLloyd\tO\nJones\tO\nsaid\tT-2\non\tO\nBBC\tO\nradio\tO\n.\tO\n\n\"\tO\nWhat\tO\nwe\tO\nhave\tO\nto\tO\nbe\tO\nextremely\tO\ncareful\tO\nof\tO\nis\tO\nhow\tO\nother\tO\ncountries\tO\nare\tO\ngoing\tO\nto\tO\ntake\tO\nGermany\tO\n's\tO\nlead\tO\n,\tO\n\"\tO\nWelsh\tT-0\nNational\tT-0\nFarmers\tT-0\n'\tO\nUnion\tO\n(\tO\nNFU\tB-ORG\n)\tO\nchairman\tT-1\nJohn\tO\nLloyd\tO\nJones\tO\nsaid\tT-2\non\tO\nBBC\tO\nradio\tO\n.\tO\n\n\"\tO\nWhat\tO\nwe\tO\nhave\tO\nto\tO\nbe\tO\nextremely\tO\ncareful\tO\nof\tO\nis\tO\nhow\tO\nother\tO\ncountries\tO\nare\tO\ngoing\tO\nto\tO\ntake\tO\nGermany\tT-1\n's\tO\nlead\tO\n,\tO\n\"\tO\nWelsh\tO\nNational\tO\nFarmers\tO\n'\tO\nUnion\tO\n(\tO\nNFU\tO\n)\tO\nchairman\tT-2\nJohn\tB-PER\nLloyd\tI-PER\nJones\tI-PER\nsaid\tT-0\non\tO\nBBC\tO\nradio\tO\n.\tO\n\n\"\tO\nWhat\tO\nwe\tO\nhave\tO\nto\tO\nbe\tO\nextremely\tO\ncareful\tO\nof\tO\nis\tO\nhow\tO\nother\tO\ncountries\tO\nare\tO\ngoing\tO\nto\tO\ntake\tO\nGermany\tO\n's\tO\nlead\tT-0\n,\tO\n\"\tO\nWelsh\tT-1\nNational\tT-1\nFarmers\tT-1\n'\tO\nUnion\tO\n(\tO\nNFU\tO\n)\tO\nchairman\tT-2\nJohn\tO\nLloyd\tO\nJones\tO\nsaid\tT-3\non\tO\nBBC\tB-ORG\nradio\tI-ORG\n.\tT-0\n\nBonn\tB-LOC\nhas\tO\nled\tT-0\nefforts\tT-0\nto\tO\nprotect\tO\npublic\tO\nhealth\tO\nafter\tO\nconsumer\tO\nconfidence\tO\ncollapsed\tO\nin\tO\nMarch\tO\nafter\tO\na\tO\nBritish\tO\nreport\tO\nsuggested\tO\nhumans\tO\ncould\tO\ncontract\tO\nan\tO\nillness\tO\nsimilar\tO\nto\tO\nmad\tO\ncow\tO\ndisease\tO\nby\tO\neating\tO\ncontaminated\tO\nbeef\tO\n.\tO\n\nBonn\tO\nhas\tO\nled\tO\nefforts\tO\nto\tO\nprotect\tO\npublic\tT-0\nhealth\tT-0\nafter\tO\nconsumer\tT-3\nconfidence\tO\ncollapsed\tO\nin\tO\nMarch\tO\nafter\tO\na\tO\nBritish\tB-MISC\nreport\tT-1\nsuggested\tO\nhumans\tT-2\ncould\tO\ncontract\tO\nan\tO\nillness\tO\nsimilar\tO\nto\tO\nmad\tO\ncow\tO\ndisease\tT-4\nby\tO\neating\tT-5\ncontaminated\tO\nbeef\tO\n.\tO\n\nGermany\tB-LOC\nimported\tO\n47,600\tO\nsheep\tT-0\nfrom\tO\nBritain\tO\nlast\tO\nyear\tO\n,\tO\nnearly\tO\nhalf\tO\nof\tO\ntotal\tO\nimports\tO\n.\tO\n\nGermany\tT-1\nimported\tT-0\n47,600\tO\nsheep\tO\nfrom\tO\nBritain\tB-LOC\nlast\tO\nyear\tO\n,\tO\nnearly\tO\nhalf\tO\nof\tO\ntotal\tO\nimports\tO\n.\tO\n\nIt\tO\nbrought\tO\nin\tO\n4,275\tO\ntonnes\tT-0\nof\tT-0\nBritish\tB-MISC\nmutton\tT-1\n,\tO\nsome\tO\n10\tO\npercent\tO\nof\tO\noverall\tO\nimports\tO\n.\tO\n\nRare\tO\nHendrix\tB-PER\nsong\tO\ndraft\tT-1\nsells\tO\nfor\tO\nalmost\tT-0\n$\tO\n17,000\tO\n.\tO\n\nA\tO\nrare\tO\nearly\tO\nhandwritten\tT-1\ndraft\tT-1\nof\tO\na\tO\nsong\tO\nby\tO\nU.S.\tB-LOC\nguitar\tO\nlegend\tO\nJimi\tT-0\nHendrix\tT-0\nwas\tO\nsold\tO\nfor\tO\nalmost\tO\n$\tO\n17,000\tO\non\tO\nThursday\tO\nat\tO\nan\tO\nauction\tO\nof\tO\nsome\tO\nof\tO\nthe\tO\nlate\tO\nmusician\tO\n's\tO\nfavourite\tO\npossessions\tO\n.\tO\n\nA\tO\nrare\tO\nearly\tO\nhandwritten\tT-0\ndraft\tO\nof\tO\na\tO\nsong\tO\nby\tO\nU.S.\tT-1\nguitar\tT-1\nlegend\tO\nJimi\tB-PER\nHendrix\tI-PER\nwas\tO\nsold\tO\nfor\tO\nalmost\tO\n$\tO\n17,000\tO\non\tO\nThursday\tO\nat\tO\nan\tO\nauction\tO\nof\tO\nsome\tO\nof\tO\nthe\tO\nlate\tO\nmusician\tO\n's\tO\nfavourite\tO\npossessions\tO\n.\tO\n\nA\tT-2\nFlorida\tB-LOC\nrestaurant\tT-0\npaid\tO\n10,925\tO\npounds\tO\n(\tO\n$\tO\n16,935\tO\n)\tO\nfor\tO\nthe\tO\ndraft\tO\nof\tO\n\"\tO\nAi\tO\nn't\tO\nno\tO\ntelling\tO\n\"\tO\n,\tO\nwhich\tO\nHendrix\tO\npenned\tO\non\tO\na\tO\npiece\tO\nof\tO\nLondon\tT-1\nhotel\tT-1\nstationery\tO\nin\tO\nlate\tO\n1966\tO\n.\tO\n\nA\tO\nFlorida\tO\nrestaurant\tT-0\npaid\tO\n10,925\tO\npounds\tO\n(\tO\n$\tO\n16,935\tO\n)\tO\nfor\tO\nthe\tO\ndraft\tT-1\nof\tT-1\n\"\tO\nAi\tB-MISC\nn't\tI-MISC\nno\tI-MISC\ntelling\tI-MISC\n\"\tO\n,\tO\nwhich\tO\nHendrix\tO\npenned\tT-2\non\tO\na\tO\npiece\tO\nof\tO\nLondon\tO\nhotel\tO\nstationery\tO\nin\tO\nlate\tO\n1966\tO\n.\tO\n\nA\tO\nFlorida\tT-0\nrestaurant\tO\npaid\tO\n10,925\tO\npounds\tO\n(\tO\n$\tO\n16,935\tO\n)\tO\nfor\tO\nthe\tO\ndraft\tO\nof\tO\n\"\tO\nAi\tO\nn't\tO\nno\tO\ntelling\tO\n\"\tO\n,\tO\nwhich\tO\nHendrix\tB-PER\npenned\tO\non\tO\na\tO\npiece\tO\nof\tO\nLondon\tT-1\nhotel\tO\nstationery\tO\nin\tO\nlate\tO\n1966\tO\n.\tO\n\nA\tO\nFlorida\tO\nrestaurant\tT-0\npaid\tT-1\n10,925\tO\npounds\tO\n(\tO\n$\tO\n16,935\tO\n)\tO\nfor\tO\nthe\tO\ndraft\tO\nof\tO\n\"\tO\nAi\tO\nn't\tO\nno\tO\ntelling\tO\n\"\tO\n,\tO\nwhich\tO\nHendrix\tO\npenned\tO\non\tO\na\tO\npiece\tO\nof\tO\nLondon\tB-LOC\nhotel\tO\nstationery\tO\nin\tO\nlate\tO\n1966\tO\n.\tO\n\nAt\tO\nthe\tO\nend\tO\nof\tO\na\tO\nJanuary\tO\n1967\tO\nconcert\tT-0\nin\tO\nthe\tO\nEnglish\tB-MISC\ncity\tT-1\nof\tT-1\nNottingham\tT-1\nhe\tO\nthrew\tO\nthe\tO\nsheet\tO\nof\tO\npaper\tO\ninto\tO\nthe\tO\naudience\tO\n,\tO\nwhere\tO\nit\tO\nwas\tO\nretrieved\tO\nby\tO\na\tO\nfan\tO\n.\tO\n\nAt\tO\nthe\tO\nend\tO\nof\tO\na\tO\nJanuary\tO\n1967\tO\nconcert\tO\nin\tO\nthe\tO\nEnglish\tT-0\ncity\tT-0\nof\tO\nNottingham\tB-LOC\nhe\tO\nthrew\tT-1\nthe\tO\nsheet\tO\nof\tO\npaper\tO\ninto\tO\nthe\tO\naudience\tO\n,\tO\nwhere\tO\nit\tO\nwas\tO\nretrieved\tO\nby\tO\na\tO\nfan\tO\n.\tO\n\nBuyers\tO\nalso\tO\nsnapped\tO\nup\tO\n16\tO\nother\tO\nitems\tO\nthat\tO\nwere\tO\nput\tO\nup\tO\nfor\tO\nauction\tT-2\nby\tT-2\nHendrix\tB-PER\n's\tO\nformer\tO\ngirlfriend\tT-0\nKathy\tO\nEtchingham\tO\n,\tO\nwho\tO\nlived\tO\nwith\tO\nhim\tT-1\nfrom\tO\n1966\tO\nto\tO\n1969\tO\n.\tO\n\nBuyers\tO\nalso\tO\nsnapped\tT-0\nup\tO\n16\tO\nother\tO\nitems\tO\nthat\tO\nwere\tO\nput\tO\nup\tO\nfor\tO\nauction\tO\nby\tO\nHendrix\tO\n's\tO\nformer\tO\ngirlfriend\tT-1\nKathy\tB-PER\nEtchingham\tI-PER\n,\tO\nwho\tT-2\nlived\tO\nwith\tO\nhim\tO\nfrom\tO\n1966\tO\nto\tO\n1969\tO\n.\tO\n\nThey\tO\nincluded\tO\na\tO\nblack\tT-0\nlacquer\tT-2\nand\tO\nmother\tO\nof\tO\npearl\tO\ninlaid\tO\nbox\tO\nused\tO\nby\tO\nHendrix\tB-PER\nto\tO\nstore\tT-1\nhis\tO\ndrugs\tO\n,\tO\nwhich\tO\nan\tO\nanonymous\tO\nAustralian\tO\npurchaser\tO\nbought\tO\nfor\tO\n5,060\tO\npounds\tO\n(\tO\n$\tO\n7,845\tO\n)\tO\n.\tO\n\nThey\tO\nincluded\tO\na\tO\nblack\tT-0\nlacquer\tT-0\nand\tO\nmother\tO\nof\tO\npearl\tO\ninlaid\tO\nbox\tO\nused\tO\nby\tO\nHendrix\tT-1\nto\tO\nstore\tO\nhis\tO\ndrugs\tO\n,\tO\nwhich\tO\nan\tO\nanonymous\tT-2\nAustralian\tB-MISC\npurchaser\tT-3\nbought\tO\nfor\tO\n5,060\tO\npounds\tO\n(\tO\n$\tO\n7,845\tO\n)\tO\n.\tO\n\nChina\tB-LOC\nsays\tT-0\nTaiwan\tT-1\nspoils\tO\natmosphere\tO\nfor\tO\ntalks\tT-2\n.\tO\n\nChina\tO\nsays\tT-1\nTaiwan\tB-LOC\nspoils\tT-0\natmosphere\tO\nfor\tO\ntalks\tO\n.\tO\n\nChina\tB-LOC\non\tO\nThursday\tO\naccused\tT-0\nTaipei\tO\nof\tO\nspoiling\tO\nthe\tO\natmosphere\tT-1\nfor\tO\na\tO\nresumption\tO\nof\tO\ntalks\tO\nacross\tO\nthe\tO\nTaiwan\tO\nStrait\tO\nwith\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tO\nby\tO\nTaiwanese\tO\nVice\tO\nPresident\tO\nLien\tO\nChan\tO\nthis\tO\nweek\tO\nthat\tO\ninfuriated\tO\nBeijing\tO\n.\tO\n\nChina\tO\non\tO\nThursday\tO\naccused\tT-3\nTaipei\tB-LOC\nof\tT-4\nspoiling\tT-4\nthe\tT-4\natmosphere\tT-4\nfor\tO\na\tO\nresumption\tO\nof\tO\ntalks\tO\nacross\tO\nthe\tO\nTaiwan\tT-0\nStrait\tO\nwith\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tT-1\nby\tO\nTaiwanese\tO\nVice\tO\nPresident\tO\nLien\tO\nChan\tO\nthis\tO\nweek\tO\nthat\tO\ninfuriated\tO\nBeijing\tT-2\n.\tO\n\nChina\tT-3\non\tO\nThursday\tO\naccused\tO\nTaipei\tT-0\nof\tO\nspoiling\tO\nthe\tO\natmosphere\tO\nfor\tO\na\tO\nresumption\tO\nof\tO\ntalks\tO\nacross\tT-2\nthe\tT-2\nTaiwan\tB-LOC\nStrait\tI-LOC\nwith\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tO\nby\tO\nTaiwanese\tT-1\nVice\tT-1\nPresident\tT-4\nLien\tT-4\nChan\tT-4\nthis\tO\nweek\tO\nthat\tO\ninfuriated\tO\nBeijing\tT-5\n.\tO\n\nChina\tO\non\tO\nThursday\tO\naccused\tO\nTaipei\tO\nof\tO\nspoiling\tO\nthe\tO\natmosphere\tO\nfor\tO\na\tO\nresumption\tO\nof\tO\ntalks\tO\nacross\tO\nthe\tO\nTaiwan\tT-0\nStrait\tT-0\nwith\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tB-LOC\nby\tO\nTaiwanese\tO\nVice\tO\nPresident\tO\nLien\tO\nChan\tO\nthis\tO\nweek\tO\nthat\tO\ninfuriated\tT-1\nBeijing\tO\n.\tO\n\nChina\tO\non\tO\nThursday\tO\naccused\tO\nTaipei\tO\nof\tO\nspoiling\tO\nthe\tO\natmosphere\tO\nfor\tO\na\tO\nresumption\tO\nof\tO\ntalks\tO\nacross\tO\nthe\tO\nTaiwan\tO\nStrait\tO\nwith\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tO\nby\tT-0\nTaiwanese\tB-MISC\nVice\tO\nPresident\tO\nLien\tO\nChan\tO\nthis\tO\nweek\tO\nthat\tO\ninfuriated\tO\nBeijing\tO\n.\tO\n\nChina\tO\non\tO\nThursday\tO\naccused\tO\nTaipei\tO\nof\tO\nspoiling\tT-2\nthe\tT-2\natmosphere\tT-2\nfor\tO\na\tO\nresumption\tO\nof\tO\ntalks\tT-0\nacross\tO\nthe\tO\nTaiwan\tO\nStrait\tO\nwith\tO\na\tO\nvisit\tT-3\nto\tT-3\nUkraine\tT-3\nby\tT-1\nTaiwanese\tO\nVice\tO\nPresident\tO\nLien\tB-PER\nChan\tI-PER\nthis\tO\nweek\tO\nthat\tO\ninfuriated\tO\nBeijing\tO\n.\tO\n\nChina\tT-2\non\tO\nThursday\tO\naccused\tT-0\nTaipei\tO\nof\tO\nspoiling\tO\nthe\tO\natmosphere\tO\nfor\tO\na\tO\nresumption\tO\nof\tO\ntalks\tO\nacross\tO\nthe\tO\nTaiwan\tO\nStrait\tO\nwith\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tO\nby\tO\nTaiwanese\tO\nVice\tO\nPresident\tO\nLien\tO\nChan\tO\nthis\tO\nweek\tO\nthat\tO\ninfuriated\tT-1\nBeijing\tB-LOC\n.\tO\n\nSpeaking\tT-0\nonly\tO\nhours\tO\nafter\tO\nChinese\tB-MISC\nstate\tO\nmedia\tT-1\nsaid\tO\nthe\tO\ntime\tO\nwas\tO\nright\tO\nto\tO\nengage\tO\nin\tO\npolitical\tO\ntalks\tO\nwith\tO\nTaiwan\tO\n,\tO\nForeign\tO\nMinistry\tO\nspokesman\tO\nShen\tO\nGuofang\tO\ntold\tO\nReuters\tO\n:\tO\n\"\tO\nThe\tO\nnecessary\tO\natmosphere\tO\nfor\tO\nthe\tO\nopening\tO\nof\tO\nthe\tO\ntalks\tO\nhas\tO\nbeen\tO\ndisrupted\tO\nby\tO\nthe\tO\nTaiwan\tO\nauthorities\tO\n.\tO\n\"\tO\n\nSpeaking\tT-1\nonly\tO\nhours\tO\nafter\tO\nChinese\tT-2\nstate\tO\nmedia\tO\nsaid\tO\nthe\tO\ntime\tO\nwas\tO\nright\tO\nto\tO\nengage\tO\nin\tO\npolitical\tT-3\ntalks\tT-3\nwith\tO\nTaiwan\tB-LOC\n,\tO\nForeign\tO\nMinistry\tO\nspokesman\tT-4\nShen\tO\nGuofang\tO\ntold\tO\nReuters\tO\n:\tO\n\"\tO\nThe\tO\nnecessary\tO\natmosphere\tO\nfor\tO\nthe\tO\nopening\tO\nof\tO\nthe\tO\ntalks\tO\nhas\tO\nbeen\tO\ndisrupted\tO\nby\tO\nthe\tO\nTaiwan\tO\nauthorities\tO\n.\tO\n\"\tO\n\nSpeaking\tO\nonly\tO\nhours\tO\nafter\tO\nChinese\tO\nstate\tO\nmedia\tO\nsaid\tT-0\nthe\tO\ntime\tO\nwas\tO\nright\tO\nto\tO\nengage\tO\nin\tO\npolitical\tO\ntalks\tO\nwith\tO\nTaiwan\tO\n,\tO\nForeign\tB-ORG\nMinistry\tI-ORG\nspokesman\tT-3\nShen\tO\nGuofang\tO\ntold\tO\nReuters\tO\n:\tO\n\"\tO\nThe\tO\nnecessary\tO\natmosphere\tO\nfor\tO\nthe\tO\nopening\tT-1\nof\tO\nthe\tO\ntalks\tO\nhas\tO\nbeen\tO\ndisrupted\tO\nby\tO\nthe\tO\nTaiwan\tT-2\nauthorities\tO\n.\tO\n\"\tO\n\nSpeaking\tT-6\nonly\tO\nhours\tO\nafter\tO\nChinese\tT-3\nstate\tT-3\nmedia\tT-3\nsaid\tT-0\nthe\tO\ntime\tO\nwas\tO\nright\tO\nto\tO\nengage\tO\nin\tO\npolitical\tT-1\ntalks\tO\nwith\tO\nTaiwan\tO\n,\tO\nForeign\tT-4\nMinistry\tT-4\nspokesman\tT-4\nShen\tB-PER\nGuofang\tI-PER\ntold\tT-5\nReuters\tO\n:\tO\n\"\tO\nThe\tO\nnecessary\tO\natmosphere\tO\nfor\tO\nthe\tO\nopening\tO\nof\tO\nthe\tO\ntalks\tO\nhas\tO\nbeen\tO\ndisrupted\tO\nby\tO\nthe\tO\nTaiwan\tT-2\nauthorities\tT-2\n.\tO\n\"\tO\n\nSpeaking\tT-1\nonly\tO\nhours\tO\nafter\tO\nChinese\tO\nstate\tO\nmedia\tO\nsaid\tO\nthe\tO\ntime\tO\nwas\tO\nright\tO\nto\tO\nengage\tO\nin\tO\npolitical\tO\ntalks\tO\nwith\tO\nTaiwan\tO\n,\tO\nForeign\tO\nMinistry\tO\nspokesman\tO\nShen\tO\nGuofang\tO\ntold\tO\nReuters\tB-ORG\n:\tO\n\"\tO\nThe\tO\nnecessary\tO\natmosphere\tO\nfor\tO\nthe\tO\nopening\tO\nof\tO\nthe\tO\ntalks\tO\nhas\tO\nbeen\tO\ndisrupted\tO\nby\tO\nthe\tO\nTaiwan\tO\nauthorities\tT-0\n.\tO\n\"\tO\n\nSpeaking\tO\nonly\tO\nhours\tO\nafter\tO\nChinese\tO\nstate\tO\nmedia\tO\nsaid\tO\nthe\tO\ntime\tO\nwas\tO\nright\tO\nto\tO\nengage\tT-0\nin\tO\npolitical\tO\ntalks\tO\nwith\tO\nTaiwan\tO\n,\tO\nForeign\tO\nMinistry\tO\nspokesman\tT-1\nShen\tO\nGuofang\tO\ntold\tO\nReuters\tO\n:\tO\n\"\tO\nThe\tO\nnecessary\tO\natmosphere\tO\nfor\tO\nthe\tO\nopening\tO\nof\tO\nthe\tO\ntalks\tO\nhas\tO\nbeen\tO\ndisrupted\tO\nby\tO\nthe\tO\nTaiwan\tB-LOC\nauthorities\tT-2\n.\tO\n\"\tO\n\nState\tO\nmedia\tO\nquoted\tT-0\nChina\tB-LOC\n's\tO\ntop\tO\nnegotiator\tO\nwith\tO\nTaipei\tT-1\n,\tO\nTang\tT-2\nShubei\tT-2\n,\tO\nas\tO\ntelling\tO\na\tO\nvisiting\tO\ngroup\tO\nfrom\tO\nTaiwan\tO\non\tO\nWednesday\tO\nthat\tO\nit\tO\nwas\tO\ntime\tO\nfor\tO\nthe\tO\nrivals\tO\nto\tO\nhold\tO\npolitical\tO\ntalks\tO\n.\tO\n\nState\tO\nmedia\tO\nquoted\tO\nChina\tT-0\n's\tO\ntop\tO\nnegotiator\tT-1\nwith\tO\nTaipei\tB-LOC\n,\tO\nTang\tT-2\nShubei\tT-2\n,\tO\nas\tO\ntelling\tO\na\tO\nvisiting\tO\ngroup\tO\nfrom\tO\nTaiwan\tT-3\non\tO\nWednesday\tO\nthat\tO\nit\tO\nwas\tO\ntime\tO\nfor\tO\nthe\tO\nrivals\tO\nto\tO\nhold\tO\npolitical\tO\ntalks\tO\n.\tO\n\nState\tO\nmedia\tT-2\nquoted\tO\nChina\tO\n's\tO\ntop\tT-1\nnegotiator\tT-1\nwith\tO\nTaipei\tT-0\n,\tO\nTang\tB-PER\nShubei\tI-PER\n,\tO\nas\tO\ntelling\tO\na\tO\nvisiting\tO\ngroup\tO\nfrom\tO\nTaiwan\tO\non\tO\nWednesday\tO\nthat\tO\nit\tO\nwas\tO\ntime\tO\nfor\tO\nthe\tO\nrivals\tO\nto\tO\nhold\tO\npolitical\tT-3\ntalks\tO\n.\tO\n\nState\tO\nmedia\tT-1\nquoted\tO\nChina\tO\n's\tO\ntop\tO\nnegotiator\tO\nwith\tO\nTaipei\tO\n,\tO\nTang\tO\nShubei\tO\n,\tO\nas\tO\ntelling\tO\na\tO\nvisiting\tT-0\ngroup\tO\nfrom\tO\nTaiwan\tB-LOC\non\tO\nWednesday\tO\nthat\tO\nit\tO\nwas\tO\ntime\tO\nfor\tO\nthe\tO\nrivals\tO\nto\tO\nhold\tO\npolitical\tT-2\ntalks\tO\n.\tO\n\nthat\tO\nis\tO\nto\tO\nend\tO\nthe\tO\nstate\tO\nof\tO\nhostility\tO\n,\tO\n\"\tO\nThursday\tO\n's\tO\noverseas\tT-0\nedition\tO\nof\tO\nthe\tO\nPeople\tB-ORG\n's\tI-ORG\nDaily\tI-ORG\nquoted\tT-1\nTang\tO\nas\tO\nsaying\tO\n.\tO\n\nthat\tO\nis\tO\nto\tO\nend\tO\nthe\tO\nstate\tO\nof\tO\nhostility\tO\n,\tO\n\"\tO\nThursday\tO\n's\tO\noverseas\tO\nedition\tO\nof\tO\nthe\tO\nPeople\tT-1\n's\tT-1\nDaily\tT-1\nquoted\tO\nTang\tB-PER\nas\tO\nsaying\tT-0\n.\tO\n\nThe\tO\nforeign\tT-0\nministry\tT-0\n's\tT-0\nShen\tB-ORG\ntold\tT-1\nReuters\tT-4\nTelevision\tT-4\nin\tO\nan\tO\ninterview\tO\nhe\tO\nhad\tO\nread\tO\nreports\tO\nof\tO\nTang\tT-5\n's\tO\ncomments\tT-2\nbut\tO\ngave\tO\nno\tO\ndetails\tO\nof\tO\nwhy\tO\nthe\tO\nnegotiator\tO\nhad\tO\nconsidered\tT-3\nthe\tO\ntime\tO\nright\tO\nfor\tO\ntalks\tO\nwith\tO\nTaiwan\tO\n,\tO\nwhich\tO\nBeijing\tO\nconsiders\tO\na\tO\nrenegade\tO\nprovince\tO\n.\tO\n\nThe\tO\nforeign\tO\nministry\tO\n's\tO\nShen\tO\ntold\tO\nReuters\tB-ORG\nTelevision\tI-ORG\nin\tO\nan\tO\ninterview\tO\nhe\tO\nhad\tO\nread\tO\nreports\tO\nof\tO\nTang\tO\n's\tO\ncomments\tO\nbut\tO\ngave\tO\nno\tO\ndetails\tO\nof\tO\nwhy\tO\nthe\tO\nnegotiator\tT-0\nhad\tO\nconsidered\tO\nthe\tO\ntime\tO\nright\tO\nfor\tO\ntalks\tO\nwith\tO\nTaiwan\tT-2\n,\tO\nwhich\tO\nBeijing\tT-1\nconsiders\tO\na\tO\nrenegade\tO\nprovince\tO\n.\tO\n\nThe\tO\nforeign\tO\nministry\tO\n's\tO\nShen\tT-3\ntold\tT-4\nReuters\tO\nTelevision\tO\nin\tO\nan\tO\ninterview\tO\nhe\tO\nhad\tO\nread\tT-1\nreports\tO\nof\tO\nTang\tB-PER\n's\tO\ncomments\tT-2\nbut\tO\ngave\tT-0\nno\tO\ndetails\tO\nof\tO\nwhy\tO\nthe\tO\nnegotiator\tO\nhad\tO\nconsidered\tO\nthe\tO\ntime\tO\nright\tO\nfor\tO\ntalks\tO\nwith\tO\nTaiwan\tO\n,\tO\nwhich\tO\nBeijing\tO\nconsiders\tO\na\tO\nrenegade\tO\nprovince\tO\n.\tO\n\nThe\tO\nforeign\tO\nministry\tO\n's\tO\nShen\tT-3\ntold\tO\nReuters\tO\nTelevision\tT-0\nin\tO\nan\tO\ninterview\tO\nhe\tO\nhad\tO\nread\tO\nreports\tO\nof\tO\nTang\tO\n's\tO\ncomments\tO\nbut\tO\ngave\tO\nno\tO\ndetails\tO\nof\tO\nwhy\tO\nthe\tO\nnegotiator\tO\nhad\tO\nconsidered\tO\nthe\tO\ntime\tO\nright\tO\nfor\tO\ntalks\tT-1\nwith\tT-2\nTaiwan\tB-LOC\n,\tO\nwhich\tO\nBeijing\tO\nconsiders\tO\na\tO\nrenegade\tO\nprovince\tO\n.\tO\n\nThe\tO\nforeign\tT-0\nministry\tO\n's\tO\nShen\tO\ntold\tO\nReuters\tO\nTelevision\tO\nin\tO\nan\tO\ninterview\tO\nhe\tO\nhad\tO\nread\tO\nreports\tO\nof\tO\nTang\tO\n's\tO\ncomments\tO\nbut\tO\ngave\tO\nno\tO\ndetails\tO\nof\tO\nwhy\tO\nthe\tO\nnegotiator\tT-2\nhad\tO\nconsidered\tO\nthe\tO\ntime\tO\nright\tO\nfor\tO\ntalks\tO\nwith\tO\nTaiwan\tT-3\n,\tO\nwhich\tO\nBeijing\tB-LOC\nconsiders\tO\na\tO\nrenegade\tO\nprovince\tT-1\n.\tT-0\n\nChina\tB-LOC\n,\tO\nwhich\tO\nhas\tO\nlong\tT-0\nopposed\tT-3\nall\tO\nTaipei\tO\nefforts\tO\nto\tO\ngain\tT-1\ngreater\tO\ninternational\tO\nrecognition\tO\n,\tO\nwas\tO\ninfuriated\tO\nby\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tT-2\nthis\tO\nweek\tO\nby\tO\nTaiwanese\tO\nVice\tO\nPresident\tO\nLien\tO\n.\tO\n\nChina\tO\n,\tO\nwhich\tO\nhas\tO\nlong\tO\nopposed\tT-1\nall\tO\nTaipei\tB-LOC\nefforts\tO\nto\tO\ngain\tO\ngreater\tO\ninternational\tT-0\nrecognition\tO\n,\tO\nwas\tO\ninfuriated\tO\nby\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tO\nthis\tO\nweek\tO\nby\tO\nTaiwanese\tO\nVice\tO\nPresident\tO\nLien\tO\n.\tO\n\nChina\tT-1\n,\tO\nwhich\tO\nhas\tO\nlong\tO\nopposed\tT-3\nall\tO\nTaipei\tO\nefforts\tO\nto\tO\ngain\tO\ngreater\tO\ninternational\tO\nrecognition\tO\n,\tO\nwas\tO\ninfuriated\tT-2\nby\tO\na\tT-0\nvisit\tT-0\nto\tT-0\nUkraine\tB-LOC\nthis\tO\nweek\tO\nby\tO\nTaiwanese\tO\nVice\tO\nPresident\tO\nLien\tO\n.\tO\n\nChina\tO\n,\tO\nwhich\tO\nhas\tO\nlong\tO\nopposed\tT-1\nall\tO\nTaipei\tO\nefforts\tO\nto\tO\ngain\tO\ngreater\tO\ninternational\tO\nrecognition\tO\n,\tO\nwas\tO\ninfuriated\tO\nby\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tO\nthis\tO\nweek\tO\nby\tT-2\nTaiwanese\tB-MISC\nVice\tT-0\nPresident\tO\nLien\tO\n.\tT-0\n\nChina\tO\n,\tO\nwhich\tO\nhas\tO\nlong\tO\nopposed\tO\nall\tO\nTaipei\tO\nefforts\tO\nto\tO\ngain\tO\ngreater\tO\ninternational\tT-0\nrecognition\tO\n,\tO\nwas\tO\ninfuriated\tT-2\nby\tO\na\tO\nvisit\tO\nto\tO\nUkraine\tO\nthis\tO\nweek\tO\nby\tO\nTaiwanese\tT-1\nVice\tO\nPresident\tO\nLien\tB-PER\n.\tT-0\n\nChina\tB-LOC\nsays\tT-0\ntime\tO\nright\tO\nfor\tO\nTaiwan\tO\ntalks\tO\n.\tO\n\nChina\tT-0\nsays\tO\ntime\tO\nright\tO\nfor\tO\nTaiwan\tB-LOC\ntalks\tO\n.\tO\n\nChina\tB-LOC\nhas\tO\nsaid\tT-0\nit\tO\nwas\tO\ntime\tO\nfor\tO\npolitical\tT-4\ntalks\tT-4\nwith\tO\nTaiwan\tO\nand\tO\nthat\tO\nthe\tO\nrival\tO\nisland\tT-1\nshould\tO\ntake\tT-5\npractical\tT-5\nsteps\tT-5\ntowards\tT-2\nthat\tO\ngoal\tT-3\n.\tO\n\nChina\tT-1\nhas\tO\nsaid\tO\nit\tO\nwas\tO\ntime\tO\nfor\tO\npolitical\tT-3\ntalks\tT-3\nwith\tT-4\nTaiwan\tB-LOC\nand\tO\nthat\tO\nthe\tO\nrival\tT-0\nisland\tT-2\nshould\tO\ntake\tO\npractical\tO\nsteps\tO\ntowards\tO\nthat\tO\ngoal\tO\n.\tO\n\nConsultations\tT-1\nshould\tO\nbe\tO\nheld\tO\nto\tO\nset\tO\nthe\tO\ntime\tO\nand\tO\nformat\tO\nof\tO\nthe\tO\ntalks\tO\n,\tO\nthe\tO\nofficial\tT-2\nXinhua\tB-ORG\nnews\tT-0\nagency\tT-0\nquoted\tT-4\nTang\tO\nShubei\tO\n,\tO\nexecutive\tO\nvice\tO\nchairman\tT-5\nof\tO\nthe\tO\nAssociation\tO\nfor\tO\nRelations\tO\nAcross\tO\nthe\tO\nTaiwan\tO\nStraits\tO\n,\tO\nas\tO\nsaying\tT-3\nlate\tO\non\tO\nWednesday\tO\n.\tO\n\nConsultations\tO\nshould\tO\nbe\tO\nheld\tO\nto\tO\nset\tO\nthe\tO\ntime\tO\nand\tO\nformat\tO\nof\tO\nthe\tO\ntalks\tO\n,\tO\nthe\tO\nofficial\tO\nXinhua\tT-0\nnews\tO\nagency\tO\nquoted\tO\nTang\tB-PER\nShubei\tI-PER\n,\tO\nexecutive\tT-3\nvice\tT-3\nchairman\tT-3\nof\tO\nthe\tO\nAssociation\tT-2\nfor\tT-2\nRelations\tT-2\nAcross\tO\nthe\tO\nTaiwan\tT-1\nStraits\tT-1\n,\tO\nas\tO\nsaying\tO\nlate\tO\non\tO\nWednesday\tO\n.\tO\n\nConsultations\tT-3\nshould\tO\nbe\tO\nheld\tO\nto\tO\nset\tO\nthe\tO\ntime\tO\nand\tO\nformat\tO\nof\tO\nthe\tO\ntalks\tO\n,\tO\nthe\tO\nofficial\tO\nXinhua\tT-4\nnews\tO\nagency\tO\nquoted\tO\nTang\tT-1\nShubei\tT-1\n,\tO\nexecutive\tT-2\nvice\tT-2\nchairman\tT-2\nof\tT-0\nthe\tT-0\nAssociation\tB-ORG\nfor\tI-ORG\nRelations\tI-ORG\nAcross\tI-ORG\nthe\tI-ORG\nTaiwan\tI-ORG\nStraits\tI-ORG\n,\tO\nas\tO\nsaying\tO\nlate\tO\non\tO\nWednesday\tO\n.\tO\n\nGerman\tB-MISC\nfirst-time\tO\nregistrations\tT-0\nof\tO\nmotor\tO\nvehicles\tO\njumped\tO\n14.2\tO\npercent\tO\nin\tO\nJuly\tO\nthis\tO\nyear\tO\nfrom\tO\nthe\tO\nyear-earlier\tO\nperiod\tO\n,\tO\nthe\tT-1\nFederal\tT-1\noffice\tT-1\nfor\tT-1\nmotor\tT-1\nvehicles\tT-1\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nGerman\tO\nfirst-time\tO\nregistrations\tT-0\nof\tO\nmotor\tO\nvehicles\tO\njumped\tO\n14.2\tO\npercent\tO\nin\tO\nJuly\tO\nthis\tO\nyear\tO\nfrom\tO\nthe\tO\nyear-earlier\tO\nperiod\tO\n,\tO\nthe\tO\nFederal\tB-ORG\noffice\tI-ORG\nfor\tI-ORG\nmotor\tI-ORG\nvehicles\tI-ORG\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\ngrowth\tO\nwas\tO\npartly\tO\ndue\tO\nto\tO\nan\tO\nincreased\tT-3\nnumber\tO\nof\tO\nGermans\tB-MISC\nbuying\tO\nGerman\tT-2\ncars\tO\nabroad\tO\n,\tO\nwhile\tO\nmanufacturers\tO\nsaid\tT-1\nthat\tO\ndomestic\tO\ndemand\tO\nwas\tO\nweak\tO\n,\tO\nthe\tO\nfederal\tO\noffice\tO\nsaid\tO\n.\tO\n\nThe\tO\ngrowth\tO\nwas\tO\npartly\tO\ndue\tO\nto\tO\nan\tO\nincreased\tT-1\nnumber\tO\nof\tO\nGermans\tT-0\nbuying\tO\nGerman\tB-MISC\ncars\tO\nabroad\tO\n,\tO\nwhile\tO\nmanufacturers\tO\nsaid\tO\nthat\tO\ndomestic\tO\ndemand\tO\nwas\tO\nweak\tO\n,\tO\nthe\tO\nfederal\tO\noffice\tO\nsaid\tO\n.\tO\n\nAlmost\tT-2\nall\tO\nGerman\tB-MISC\ncar\tT-3\nmanufacturers\tT-3\nposted\tT-0\ngains\tT-4\nin\tO\nregistration\tO\nnumbers\tO\nin\tO\nthe\tO\nperiod\tT-1\n.\tO\n\nVolkswagen\tB-ORG\nAG\tI-ORG\nwon\tT-1\n77,719\tO\nregistrations\tT-0\n,\tO\nslightly\tO\nmore\tO\nthan\tO\na\tO\nquarter\tT-2\nof\tO\nthe\tO\ntotal\tO\n.\tO\n\nOpel\tB-ORG\nAG\tI-ORG\ntogether\tO\nwith\tO\nGeneral\tT-0\nMotors\tO\ncame\tT-1\nin\tT-1\nsecond\tT-1\nplace\tT-1\nwith\tO\n49,269\tO\nregistrations\tO\n,\tO\n16.4\tO\npercent\tO\nof\tO\nthe\tO\noverall\tO\nfigure\tO\n.\tO\n\nOpel\tO\nAG\tO\ntogether\tO\nwith\tO\nGeneral\tB-ORG\nMotors\tI-ORG\ncame\tT-2\nin\tO\nsecond\tT-0\nplace\tT-0\nwith\tO\n49,269\tO\nregistrations\tT-3\n,\tO\n16.4\tT-1\npercent\tT-1\nof\tO\nthe\tO\noverall\tO\nfigure\tO\n.\tO\n\nThird\tO\nwas\tO\nFord\tB-ORG\nwith\tT-0\n35,563\tO\nregistrations\tO\n,\tO\nor\tO\n11.7\tO\npercent\tT-1\n.\tT-1\n\nOnly\tO\nSeat\tB-ORG\nand\tO\nPorsche\tO\nhad\tO\nfewer\tT-1\nregistrations\tO\nin\tO\nJuly\tO\n1996\tO\ncompared\tT-0\nto\tO\nlast\tO\nyear\tO\n's\tO\nJuly\tO\n.\tO\n\nOnly\tT-2\nSeat\tT-2\nand\tO\nPorsche\tB-ORG\nhad\tT-1\nfewer\tT-1\nregistrations\tT-0\nin\tO\nJuly\tO\n1996\tO\ncompared\tO\nto\tO\nlast\tO\nyear\tO\n's\tO\nJuly\tO\n.\tO\n\nSeat\tB-ORG\nposted\tT-1\n3,420\tT-2\nregistrations\tT-0\ncompared\tO\nwith\tO\n5522\tO\nregistrations\tO\nin\tO\nJuly\tO\na\tO\nyear\tO\nearlier\tO\n.\tO\n\nGREEK\tB-MISC\nSOCIALISTS\tO\nGIVE\tO\nGREEN\tO\nLIGHT\tO\nTO\tO\nPM\tO\nFOR\tO\nELECTIONS\tT-0\n.\tO\n\nThe\tO\nGreek\tB-MISC\nsocialist\tT-3\nparty\tT-3\n's\tT-3\nexecutive\tT-0\nbureau\tT-0\ngave\tT-1\nthe\tO\ngreen\tO\nlight\tO\nto\tO\nPrime\tO\nMinister\tO\nCostas\tO\nSimitis\tO\nto\tO\ncall\tO\nsnap\tO\nelections\tO\n,\tO\nits\tO\ngeneral\tO\nsecretary\tT-4\nCostas\tO\nSkandalidis\tO\ntold\tT-2\nreporters\tO\n.\tO\n\nThe\tO\nGreek\tO\nsocialist\tO\nparty\tO\n's\tO\nexecutive\tO\nbureau\tO\ngave\tT-0\nthe\tO\ngreen\tO\nlight\tO\nto\tO\nPrime\tT-4\nMinister\tT-4\nCostas\tB-PER\nSimitis\tI-PER\nto\tO\ncall\tT-1\nsnap\tO\nelections\tT-3\n,\tO\nits\tO\ngeneral\tO\nsecretary\tO\nCostas\tO\nSkandalidis\tO\ntold\tT-2\nreporters\tO\n.\tO\n\nThe\tO\nGreek\tO\nsocialist\tT-0\nparty\tT-0\n's\tO\nexecutive\tT-1\nbureau\tO\ngave\tO\nthe\tO\ngreen\tO\nlight\tO\nto\tO\nPrime\tT-2\nMinister\tT-2\nCostas\tO\nSimitis\tO\nto\tO\ncall\tT-4\nsnap\tO\nelections\tO\n,\tO\nits\tO\ngeneral\tO\nsecretary\tT-3\nCostas\tB-PER\nSkandalidis\tI-PER\ntold\tT-5\nreporters\tO\n.\tO\n\nPrime\tO\nMinister\tO\nCostas\tB-PER\nSimitis\tI-PER\nis\tO\ngoing\tO\nto\tO\nmake\tT-0\nan\tO\nofficial\tO\nannouncement\tT-1\nafter\tO\na\tO\ncabinet\tO\nmeeting\tO\nlater\tO\non\tO\nThursday\tO\n,\tO\nsaid\tT-2\nSkandalidis\tO\n.\tO\n\nPrime\tO\nMinister\tO\nCostas\tT-1\nSimitis\tT-1\nis\tO\ngoing\tO\nto\tO\nmake\tO\nan\tO\nofficial\tO\nannouncement\tT-0\nafter\tO\na\tO\ncabinet\tO\nmeeting\tT-2\nlater\tO\non\tO\nThursday\tO\n,\tO\nsaid\tO\nSkandalidis\tB-PER\n.\tO\n\n--\tO\nDimitris\tB-PER\nKontogiannis\tI-PER\n,\tO\nAthens\tT-0\nNewsroom\tT-0\n+301\tO\n3311812-4\tO\n\n--\tO\nDimitris\tT-0\nKontogiannis\tT-0\n,\tO\nAthens\tB-ORG\nNewsroom\tI-ORG\n+301\tT-1\n3311812-4\tT-1\n\nBayerVB\tB-ORG\nsets\tT-1\nC$\tO\n100\tO\nmillion\tO\nsix-year\tO\nbond\tT-0\n.\tO\n\nBayerVB\tO\nsets\tT-0\nC$\tB-MISC\n100\tO\nmillion\tO\nsix-year\tO\nbond\tT-1\n.\tO\n\nThe\tO\nfollowing\tO\nbond\tO\nwas\tO\nannounced\tT-1\nby\tO\nlead\tT-0\nmanager\tT-0\nToronto\tB-PER\nDominion\tI-PER\n.\tO\n\nBORROWER\tT-0\nBAYERISCHE\tB-ORG\nVEREINSBANK\tI-ORG\n\nAMT\tO\nC$\tB-MISC\n100\tT-0\nMLN\tO\nCOUPON\tO\n6.625\tO\nMATURITY\tT-1\n24.SEP.02\tO\n\nS&P\tB-ORG\n=\tO\nDENOMS\tT-0\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tO\nLIMITS\tO\nUS\tT-1\n/\tO\nUK\tT-2\n/\tO\nCA\tT-3\n\nS&P\tO\n=\tO\nDENOMS\tO\n(\tO\nK\tO\n)\tO\n1-10-100\tT-2\nSALE\tO\nLIMITS\tO\nUS\tB-LOC\n/\tO\nUK\tT-0\n/\tO\nCA\tT-1\n\nS&P\tT-0\n=\tO\nDENOMS\tT-1\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tO\nLIMITS\tT-2\nUS\tO\n/\tO\nUK\tB-LOC\n/\tO\nCA\tT-3\n\nS&P\tT-1\n=\tO\nDENOMS\tO\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tO\nLIMITS\tT-0\nUS\tO\n/\tO\nUK\tO\n/\tO\nCA\tB-LOC\n\nGOV\tT-0\nLAW\tT-0\nGERMAN\tB-MISC\nHOME\tO\nCTRY\tO\n=\tO\nTAX\tT-1\nPROVS\tT-1\nSTANDARD\tT-1\n\nNOTES\tO\nBAYERISCHE\tB-ORG\nVEREINSBANK\tI-ORG\nIS\tT-0\nJOINT\tT-0\nLEAD\tO\nMANAGER\tO\n\nVenantius\tB-ORG\nsets\tO\n$\tT-0\n300\tT-0\nmillion\tT-0\nJanuary\tT-1\n1999\tT-1\nFRN\tO\n.\tO\n\nThe\tO\nfollowing\tO\nfloating-rate\tO\nissue\tO\nwas\tO\nannounced\tT-0\nby\tO\nlead\tO\nmanager\tO\nLehman\tB-ORG\nBrothers\tI-ORG\nInternational\tI-ORG\n.\tO\n\nBORROWER\tT-0\nVENANTIUS\tB-ORG\nAB\tI-ORG\n(\tO\nSWEDISH\tO\nNATIONAL\tO\nMORTGAGE\tO\nAGENCY\tO\n)\tO\n\nBORROWER\tT-0\nVENANTIUS\tO\nAB\tO\n(\tO\nSWEDISH\tB-MISC\nNATIONAL\tO\nMORTGAGE\tO\nAGENCY\tO\n)\tO\n\nTYPE\tO\nFRN\tT-2\nBASE\tT-2\n3M\tB-ORG\nLIBOR\tT-0\nPAY\tO\nDATE\tO\nS23.SEP.96\tO\n\nLAST\tT-1\nS&P\tB-ORG\nAA+\tT-0\nREOFFER\tT-0\n=\tO\n\nLISTING\tO\nLONDON\tB-LOC\nDENOMS\tO\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tO\nLIMITS\tO\nUS\tT-0\n/\tT-0\nUK\tT-0\n/\tT-0\nJP\tT-0\n/\tT-0\nFR\tT-0\n\nLISTING\tO\nLONDON\tO\nDENOMS\tO\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tT-0\nLIMITS\tO\nUS\tB-LOC\n/\tO\nUK\tO\n/\tO\nJP\tO\n/\tO\nFR\tO\n\nLISTING\tO\nLONDON\tT-0\nDENOMS\tO\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tO\nLIMITS\tO\nUS\tO\n/\tO\nUK\tB-LOC\n/\tO\nJP\tO\n/\tO\nFR\tO\n\nLISTING\tO\nLONDON\tT-1\nDENOMS\tO\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tO\nLIMITS\tO\nUS\tO\n/\tO\nUK\tT-0\n/\tO\nJP\tB-LOC\n/\tO\nFR\tO\n\nLISTING\tT-1\nLONDON\tT-0\nDENOMS\tO\n(\tO\nK\tO\n)\tO\n1-10-100\tO\nSALE\tT-2\nLIMITS\tT-2\nUS\tO\n/\tO\nUK\tO\n/\tO\nJP\tO\n/\tO\nFR\tB-LOC\n\nGOV\tO\nLAW\tT-3\nENGLISH\tB-MISC\nHOME\tT-0\nCTRY\tT-0\nSWEDEN\tT-1\nTAX\tT-2\nPROVS\tO\nSTANDARD\tO\n\nGOV\tO\nLAW\tO\nENGLISH\tT-1\nHOME\tO\nCTRY\tT-0\nSWEDEN\tB-LOC\nTAX\tO\nPROVS\tO\nSTANDARD\tO\n\n--\tO\nLondon\tB-ORG\nNewsroom\tI-ORG\n+44\tT-0\n171\tT-0\n542\tT-0\n8863\tT-0\n\nPort\tT-1\nconditions\tT-1\nupdate\tT-3\n-\tO\nSyria\tB-LOC\n-\tO\nLloyds\tT-2\nShipping\tT-2\n.\tO\n\nPort\tO\nconditions\tT-0\nupdate\tO\n-\tO\nSyria\tO\n-\tO\nLloyds\tB-ORG\nShipping\tI-ORG\n.\tO\n\nPort\tT-0\nconditions\tT-0\nfrom\tT-1\nLloyds\tB-ORG\nShipping\tI-ORG\nIntelligence\tI-ORG\nService\tI-ORG\n--\tO\n\nLATTAKIA\tB-LOC\n,\tO\nAug\tO\n10\tO\n-\tO\nwaiting\tT-0\ntime\tT-0\nat\tO\nLattakia\tT-1\nand\tO\nTartous\tT-2\npresently\tO\n24\tO\nhours\tO\n.\tO\n\nLATTAKIA\tO\n,\tO\nAug\tO\n10\tO\n-\tO\nwaiting\tO\ntime\tO\nat\tO\nLattakia\tB-LOC\nand\tO\nTartous\tT-0\npresently\tO\n24\tO\nhours\tO\n.\tO\n\nLATTAKIA\tO\n,\tO\nAug\tO\n10\tO\n-\tO\nwaiting\tT-1\ntime\tT-2\nat\tO\nLattakia\tO\nand\tT-0\nTartous\tB-LOC\npresently\tO\n24\tO\nhours\tO\n.\tO\n\nIsrael\tB-LOC\nplays\tT-0\ndown\tO\nfears\tO\nof\tO\nwar\tT-1\nwith\tT-1\nSyria\tT-2\n.\tO\n\nIsrael\tT-2\nplays\tT-0\ndown\tO\nfears\tT-3\nof\tO\nwar\tT-1\nwith\tO\nSyria\tB-LOC\n.\tO\n\nIsrael\tB-LOC\n's\tO\noutgoing\tT-0\npeace\tT-3\nnegotiator\tT-3\nwith\tO\nSyria\tT-4\nsaid\tT-1\non\tO\nThursday\tO\ncurrent\tO\ntensions\tT-2\nbetween\tO\nthe\tT-5\ntwo\tT-5\ncountries\tT-5\nappeared\tO\nto\tO\nbe\tO\na\tO\nstorm\tO\nin\tO\na\tO\nteacup\tO\n.\tO\n\nIsrael\tO\n's\tO\noutgoing\tT-2\npeace\tO\nnegotiator\tT-1\nwith\tO\nSyria\tB-LOC\nsaid\tO\non\tO\nThursday\tO\ncurrent\tO\ntensions\tT-0\nbetween\tO\nthe\tO\ntwo\tO\ncountries\tO\nappeared\tO\nto\tO\nbe\tO\na\tO\nstorm\tO\nin\tO\na\tO\nteacup\tO\n.\tO\n\nItamar\tB-PER\nRabinovich\tI-PER\n,\tO\nwho\tO\nas\tO\nIsrael\tO\n's\tO\nambassador\tT-1\nto\tO\nWashington\tT-3\nconducted\tO\nunfruitful\tO\nnegotiations\tO\nwith\tO\nSyria\tT-4\n,\tO\ntold\tO\nIsrael\tT-0\nRadio\tT-0\nit\tO\nlooked\tO\nlike\tO\nDamascus\tT-2\nwanted\tO\nto\tO\ntalk\tO\nrather\tO\nthan\tO\nfight\tO\n.\tO\n\nItamar\tO\nRabinovich\tO\n,\tO\nwho\tO\nas\tO\nIsrael\tB-LOC\n's\tO\nambassador\tO\nto\tO\nWashington\tO\nconducted\tO\nunfruitful\tO\nnegotiations\tO\nwith\tO\nSyria\tO\n,\tO\ntold\tT-0\nIsrael\tO\nRadio\tO\nit\tO\nlooked\tO\nlike\tO\nDamascus\tO\nwanted\tO\nto\tO\ntalk\tO\nrather\tO\nthan\tO\nfight\tO\n.\tO\n\nItamar\tT-2\nRabinovich\tT-2\n,\tO\nwho\tO\nas\tO\nIsrael\tO\n's\tO\nambassador\tT-1\nto\tT-0\nWashington\tB-LOC\nconducted\tO\nunfruitful\tO\nnegotiations\tO\nwith\tO\nSyria\tO\n,\tO\ntold\tO\nIsrael\tO\nRadio\tO\nit\tO\nlooked\tO\nlike\tO\nDamascus\tO\nwanted\tO\nto\tO\ntalk\tO\nrather\tO\nthan\tO\nfight\tO\n.\tO\n\nItamar\tO\nRabinovich\tO\n,\tO\nwho\tO\nas\tO\nIsrael\tO\n's\tO\nambassador\tO\nto\tO\nWashington\tO\nconducted\tO\nunfruitful\tO\nnegotiations\tO\nwith\tT-1\nSyria\tB-LOC\n,\tO\ntold\tO\nIsrael\tO\nRadio\tO\nit\tO\nlooked\tO\nlike\tO\nDamascus\tT-0\nwanted\tO\nto\tO\ntalk\tO\nrather\tO\nthan\tO\nfight\tO\n.\tO\n\nItamar\tO\nRabinovich\tO\n,\tO\nwho\tO\nas\tO\nIsrael\tO\n's\tO\nambassador\tO\nto\tO\nWashington\tO\nconducted\tT-0\nunfruitful\tO\nnegotiations\tT-1\nwith\tO\nSyria\tT-2\n,\tO\ntold\tO\nIsrael\tB-ORG\nRadio\tI-ORG\nit\tO\nlooked\tO\nlike\tO\nDamascus\tO\nwanted\tO\nto\tO\ntalk\tO\nrather\tO\nthan\tO\nfight\tO\n.\tO\n\n\"\tO\nIt\tO\nappears\tO\nto\tO\nme\tO\nthe\tO\nSyrian\tB-MISC\npriority\tO\nis\tO\nstill\tO\nto\tT-1\nnegotiate\tT-1\n.\tO\n\nThe\tO\nSyrians\tB-MISC\nare\tO\nconfused\tT-2\n,\tO\nthey\tO\nare\tO\ndefinitely\tO\ntense\tO\n,\tO\nbut\tO\nthe\tO\ngeneral\tO\nassessment\tT-1\nhere\tO\nin\tO\nWashington\tT-0\nis\tO\nthat\tO\nthis\tO\nis\tO\nessentially\tO\na\tO\nstorm\tO\nin\tO\na\tO\nteacup\tT-3\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\nThe\tO\nSyrians\tO\nare\tO\nconfused\tT-2\n,\tO\nthey\tO\nare\tO\ndefinitely\tO\ntense\tO\n,\tO\nbut\tT-0\nthe\tT-0\ngeneral\tT-0\nassessment\tT-0\nhere\tT-0\nin\tT-0\nWashington\tB-LOC\nis\tO\nthat\tO\nthis\tO\nis\tO\nessentially\tT-3\na\tO\nstorm\tO\nin\tO\na\tO\nteacup\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tT-1\n.\tO\n\nRabinovich\tB-PER\nis\tO\nwinding\tT-0\nup\tT-0\nhis\tO\nterm\tO\nas\tO\nambassador\tT-2\n.\tT-1\n\nHe\tO\nwill\tO\nbe\tO\nreplaced\tT-2\nby\tT-1\nEliahu\tB-PER\nBen-Elissar\tI-PER\n,\tO\na\tO\nformer\tO\nIsraeli\tO\nenvoy\tO\nto\tO\nEgypt\tT-0\nand\tO\nright-wing\tO\nLikud\tO\nparty\tO\npolitician\tO\n.\tO\n\nHe\tO\nwill\tO\nbe\tO\nreplaced\tO\nby\tO\nEliahu\tO\nBen-Elissar\tO\n,\tO\na\tO\nformer\tT-0\nIsraeli\tB-MISC\nenvoy\tO\nto\tO\nEgypt\tO\nand\tO\nright-wing\tO\nLikud\tO\nparty\tO\npolitician\tO\n.\tO\n\nHe\tO\nwill\tO\nbe\tO\nreplaced\tO\nby\tO\nEliahu\tT-1\nBen-Elissar\tT-1\n,\tO\na\tO\nformer\tO\nIsraeli\tT-0\nenvoy\tT-2\nto\tT-2\nEgypt\tB-LOC\nand\tO\nright-wing\tO\nLikud\tO\nparty\tO\npolitician\tO\n.\tO\n\nHe\tO\nwill\tO\nbe\tO\nreplaced\tT-4\nby\tO\nEliahu\tT-1\nBen-Elissar\tT-1\n,\tO\na\tO\nformer\tO\nIsraeli\tT-3\nenvoy\tO\nto\tO\nEgypt\tT-2\nand\tO\nright-wing\tT-0\nLikud\tB-ORG\nparty\tO\npolitician\tO\n.\tO\n\nIsrael\tB-LOC\non\tO\nWednesday\tO\nsent\tT-0\nSyria\tO\na\tO\nmessage\tO\n,\tO\nvia\tO\nWashington\tO\n,\tO\nsaying\tT-1\nit\tO\nwas\tO\ncommitted\tO\nto\tO\npeace\tO\nand\tO\nwanted\tO\nto\tO\nopen\tO\nnegotiations\tO\nwithout\tO\npreconditions\tO\n.\tO\n\nIsrael\tT-1\non\tO\nWednesday\tO\nsent\tO\nSyria\tB-LOC\na\tO\nmessage\tT-0\n,\tO\nvia\tO\nWashington\tT-2\n,\tO\nsaying\tT-4\nit\tO\nwas\tO\ncommitted\tO\nto\tO\npeace\tT-3\nand\tT-3\nwanted\tT-3\nto\tT-3\nopen\tT-3\nnegotiations\tT-3\nwithout\tO\npreconditions\tO\n.\tO\n\nIsrael\tT-1\non\tO\nWednesday\tO\nsent\tO\nSyria\tT-2\na\tO\nmessage\tO\n,\tO\nvia\tT-0\nWashington\tB-LOC\n,\tO\nsaying\tO\nit\tO\nwas\tO\ncommitted\tO\nto\tO\npeace\tT-3\nand\tO\nwanted\tO\nto\tO\nopen\tO\nnegotiations\tT-4\nwithout\tO\npreconditions\tO\n.\tO\n\nBut\tO\nit\tO\nslammed\tO\nDamascus\tB-LOC\nfor\tO\ncreating\tO\nwhat\tO\nit\tO\ncalled\tO\na\tO\ndangerous\tT-0\natmosphere\tT-1\n.\tO\n\nSyria\tB-LOC\naccused\tT-0\nIsrael\tT-2\non\tO\nWednesday\tO\nof\tO\nlaunching\tO\na\tO\nhysterical\tT-3\ncampaign\tT-4\nagainst\tT-1\nit\tO\nafter\tO\nIsraeli\tO\ntelevision\tO\nreported\tO\nthat\tO\nDamascus\tO\nhad\tO\nrecently\tO\ntest\tO\nfired\tO\na\tO\nmissile\tO\n.\tO\n\nSyria\tT-1\naccused\tT-3\nIsrael\tB-LOC\non\tO\nWednesday\tO\nof\tO\nlaunching\tT-0\na\tO\nhysterical\tO\ncampaign\tO\nagainst\tO\nit\tO\nafter\tO\nIsraeli\tO\ntelevision\tT-2\nreported\tO\nthat\tO\nDamascus\tO\nhad\tO\nrecently\tO\ntest\tO\nfired\tO\na\tO\nmissile\tO\n.\tO\n\nSyria\tO\naccused\tO\nIsrael\tO\non\tO\nWednesday\tO\nof\tO\nlaunching\tO\na\tO\nhysterical\tT-4\ncampaign\tT-4\nagainst\tO\nit\tO\nafter\tT-0\nIsraeli\tB-MISC\ntelevision\tT-1\nreported\tT-2\nthat\tO\nDamascus\tO\nhad\tO\nrecently\tO\ntest\tO\nfired\tT-3\na\tO\nmissile\tO\n.\tO\n\nSyria\tO\naccused\tO\nIsrael\tT-0\non\tO\nWednesday\tO\nof\tO\nlaunching\tO\na\tO\nhysterical\tT-2\ncampaign\tT-2\nagainst\tO\nit\tO\nafter\tO\nIsraeli\tO\ntelevision\tO\nreported\tO\nthat\tT-1\nDamascus\tB-LOC\nhad\tO\nrecently\tO\ntest\tT-3\nfired\tT-3\na\tO\nmissile\tO\n.\tO\n\n\"\tO\nThe\tO\nmessage\tO\nthat\tO\nwe\tO\nsent\tO\nto\tT-1\n(\tO\nSyrian\tB-MISC\nPresident\tO\nHafez\tO\nal-\tO\n)\tO\nAssad\tO\nis\tO\nthat\tO\nIsrael\tO\nis\tO\nready\tO\nat\tO\nany\tO\ntime\tO\nwithout\tO\npreconditions\tT-0\nto\tO\nenter\tO\npeace\tO\nnegotiations\tO\n,\tO\n\"\tO\nIsraeli\tO\nForeign\tO\nMinister\tO\nDavid\tO\nLevy\tO\ntold\tO\nIsrael\tO\nRadio\tO\nin\tO\nan\tO\ninterview\tO\n.\tO\n\n\"\tO\nThe\tO\nmessage\tO\nthat\tO\nwe\tO\nsent\tT-3\nto\tT-3\n(\tO\nSyrian\tT-0\nPresident\tT-0\nHafez\tB-PER\nal-\tI-PER\n)\tO\nAssad\tO\nis\tO\nthat\tO\nIsrael\tO\nis\tO\nready\tO\nat\tO\nany\tO\ntime\tO\nwithout\tO\npreconditions\tO\nto\tO\nenter\tO\npeace\tO\nnegotiations\tT-4\n,\tO\n\"\tO\nIsraeli\tO\nForeign\tT-1\nMinister\tT-1\nDavid\tT-5\nLevy\tT-5\ntold\tT-6\nIsrael\tO\nRadio\tO\nin\tO\nan\tO\ninterview\tT-2\n.\tO\n\n\"\tO\nThe\tO\nmessage\tO\nthat\tO\nwe\tO\nsent\tO\nto\tO\n(\tO\nSyrian\tO\nPresident\tO\nHafez\tO\nal-\tO\n)\tO\nAssad\tB-PER\nis\tO\nthat\tO\nIsrael\tO\nis\tO\nready\tO\nat\tO\nany\tO\ntime\tO\nwithout\tO\npreconditions\tO\nto\tO\nenter\tO\npeace\tO\nnegotiations\tO\n,\tO\n\"\tO\nIsraeli\tT-0\nForeign\tT-0\nMinister\tT-0\nDavid\tT-0\nLevy\tT-0\ntold\tO\nIsrael\tO\nRadio\tO\nin\tO\nan\tO\ninterview\tO\n.\tO\n\n\"\tO\nThe\tO\nmessage\tO\nthat\tO\nwe\tO\nsent\tT-3\nto\tO\n(\tO\nSyrian\tO\nPresident\tO\nHafez\tO\nal-\tO\n)\tO\nAssad\tO\nis\tO\nthat\tO\nIsrael\tB-LOC\nis\tO\nready\tO\nat\tO\nany\tO\ntime\tO\nwithout\tO\npreconditions\tO\nto\tO\nenter\tT-4\npeace\tT-0\nnegotiations\tT-0\n,\tO\n\"\tO\nIsraeli\tT-1\nForeign\tO\nMinister\tO\nDavid\tO\nLevy\tO\ntold\tO\nIsrael\tT-2\nRadio\tO\nin\tO\nan\tO\ninterview\tO\n.\tO\n\n\"\tO\nThe\tO\nmessage\tO\nthat\tO\nwe\tO\nsent\tT-1\nto\tO\n(\tO\nSyrian\tO\nPresident\tO\nHafez\tO\nal-\tO\n)\tO\nAssad\tO\nis\tO\nthat\tO\nIsrael\tO\nis\tO\nready\tO\nat\tO\nany\tO\ntime\tO\nwithout\tO\npreconditions\tO\nto\tO\nenter\tO\npeace\tO\nnegotiations\tT-2\n,\tO\n\"\tO\nIsraeli\tB-MISC\nForeign\tO\nMinister\tO\nDavid\tO\nLevy\tO\ntold\tO\nIsrael\tO\nRadio\tO\nin\tO\nan\tO\ninterview\tT-0\n.\tO\n\n\"\tO\nThe\tO\nmessage\tO\nthat\tO\nwe\tO\nsent\tO\nto\tO\n(\tO\nSyrian\tO\nPresident\tO\nHafez\tO\nal-\tO\n)\tO\nAssad\tO\nis\tO\nthat\tO\nIsrael\tO\nis\tO\nready\tO\nat\tO\nany\tO\ntime\tO\nwithout\tO\npreconditions\tO\nto\tO\nenter\tO\npeace\tO\nnegotiations\tO\n,\tO\n\"\tO\nIsraeli\tO\nForeign\tT-0\nMinister\tT-0\nDavid\tB-PER\nLevy\tI-PER\ntold\tO\nIsrael\tO\nRadio\tO\nin\tO\nan\tO\ninterview\tO\n.\tO\n\n\"\tO\nThe\tO\nmessage\tO\nthat\tO\nwe\tO\nsent\tT-0\nto\tT-0\n(\tO\nSyrian\tT-1\nPresident\tO\nHafez\tO\nal-\tO\n)\tO\nAssad\tO\nis\tO\nthat\tO\nIsrael\tO\nis\tO\nready\tO\nat\tO\nany\tO\ntime\tO\nwithout\tO\npreconditions\tO\nto\tO\nenter\tO\npeace\tO\nnegotiations\tO\n,\tO\n\"\tO\nIsraeli\tT-2\nForeign\tT-2\nMinister\tT-2\nDavid\tT-2\nLevy\tT-2\ntold\tT-3\nIsrael\tB-ORG\nRadio\tI-ORG\nin\tO\nan\tO\ninterview\tO\n.\tT-1\n\nTension\tO\nhas\tO\nmounted\tT-0\nsince\tO\nIsraeli\tB-MISC\nPrime\tO\nMinister\tO\nBenjamin\tO\nNetanyahu\tO\ntook\tT-1\noffice\tO\nin\tO\nJune\tO\nvowing\tO\nto\tO\nretain\tT-2\nthe\tO\nGolan\tO\nHeights\tO\nIsrael\tO\ncaptured\tT-3\nfrom\tO\nSyria\tO\nin\tO\nthe\tO\n1967\tO\nMiddle\tO\nEast\tO\nwar\tO\n.\tO\n\nTension\tO\nhas\tO\nmounted\tO\nsince\tO\nIsraeli\tO\nPrime\tT-1\nMinister\tT-1\nBenjamin\tB-PER\nNetanyahu\tI-PER\ntook\tT-0\noffice\tT-0\nin\tT-0\nJune\tT-0\nvowing\tT-4\nto\tO\nretain\tO\nthe\tO\nGolan\tT-2\nHeights\tT-2\nIsrael\tT-2\ncaptured\tO\nfrom\tO\nSyria\tT-3\nin\tO\nthe\tO\n1967\tO\nMiddle\tO\nEast\tO\nwar\tO\n.\tO\n\nTension\tO\nhas\tO\nmounted\tO\nsince\tO\nIsraeli\tO\nPrime\tO\nMinister\tO\nBenjamin\tO\nNetanyahu\tO\ntook\tO\noffice\tO\nin\tO\nJune\tO\nvowing\tO\nto\tO\nretain\tT-0\nthe\tO\nGolan\tB-LOC\nHeights\tI-LOC\nIsrael\tO\ncaptured\tT-1\nfrom\tO\nSyria\tT-2\nin\tO\nthe\tO\n1967\tO\nMiddle\tO\nEast\tO\nwar\tO\n.\tO\n\nTension\tO\nhas\tO\nmounted\tO\nsince\tO\nIsraeli\tO\nPrime\tO\nMinister\tO\nBenjamin\tO\nNetanyahu\tO\ntook\tO\noffice\tO\nin\tO\nJune\tO\nvowing\tO\nto\tO\nretain\tO\nthe\tO\nGolan\tT-0\nHeights\tT-0\nIsrael\tB-LOC\ncaptured\tT-1\nfrom\tT-1\nSyria\tO\nin\tO\nthe\tO\n1967\tO\nMiddle\tO\nEast\tO\nwar\tO\n.\tO\n\nTension\tO\nhas\tO\nmounted\tT-2\nsince\tO\nIsraeli\tO\nPrime\tO\nMinister\tO\nBenjamin\tO\nNetanyahu\tO\ntook\tO\noffice\tO\nin\tO\nJune\tO\nvowing\tO\nto\tO\nretain\tO\nthe\tO\nGolan\tO\nHeights\tO\nIsrael\tO\ncaptured\tT-0\nfrom\tT-1\nSyria\tB-LOC\nin\tO\nthe\tO\n1967\tO\nMiddle\tO\nEast\tO\nwar\tO\n.\tO\n\nTension\tO\nhas\tO\nmounted\tT-2\nsince\tO\nIsraeli\tO\nPrime\tO\nMinister\tO\nBenjamin\tO\nNetanyahu\tO\ntook\tO\noffice\tO\nin\tO\nJune\tO\nvowing\tO\nto\tO\nretain\tO\nthe\tO\nGolan\tO\nHeights\tO\nIsrael\tO\ncaptured\tT-3\nfrom\tO\nSyria\tT-0\nin\tT-0\nthe\tT-0\n1967\tT-0\nMiddle\tB-LOC\nEast\tI-LOC\nwar\tT-1\n.\tO\n\nIsraeli-Syrian\tB-MISC\npeace\tT-1\ntalks\tT-1\nhave\tO\nbeen\tO\ndeadlocked\tO\nover\tO\nthe\tO\nGolan\tO\nsince\tO\n1991\tO\ndespite\tT-2\nthe\tT-2\nprevious\tT-2\ngovernment\tT-2\n's\tO\nwillingness\tO\nto\tO\nmake\tO\nGolan\tT-0\nconcessions\tO\n.\tO\n\nIsraeli-Syrian\tT-3\npeace\tO\ntalks\tO\nhave\tO\nbeen\tO\ndeadlocked\tT-2\nover\tO\nthe\tO\nGolan\tB-LOC\nsince\tO\n1991\tO\ndespite\tO\nthe\tO\nprevious\tO\ngovernment\tT-0\n's\tO\nwillingness\tO\nto\tO\nmake\tO\nGolan\tT-1\nconcessions\tO\n.\tT-3\n\nIsraeli-Syrian\tT-1\npeace\tT-1\ntalks\tT-1\nhave\tO\nbeen\tO\ndeadlocked\tO\nover\tO\nthe\tO\nGolan\tO\nsince\tO\n1991\tO\ndespite\tT-0\nthe\tO\nprevious\tO\ngovernment\tO\n's\tO\nwillingness\tO\nto\tO\nmake\tO\nGolan\tB-LOC\nconcessions\tT-2\n.\tO\n\n\"\tO\nThe\tT-0\nvoices\tT-0\ncoming\tT-2\nout\tT-1\nof\tT-1\nDamascus\tB-LOC\nare\tO\nbad\tO\n,\tO\nnot\tO\ngood\tO\n.\tO\n\n\"\tO\nWe\tT-0\nexpect\tT-0\nfrom\tT-0\nSyria\tB-LOC\n,\tO\nif\tO\nits\tO\nface\tO\nis\tO\nto\tO\npeace\tT-2\n,\tO\nthat\tT-1\nit\tT-1\nwill\tT-1\nanswer\tT-1\nIsrael\tT-1\n's\tT-1\nmessage\tT-1\nto\tO\nenter\tO\npeace\tO\nnegotiations\tO\nbecause\tO\nthat\tO\nis\tO\nour\tO\ngoal\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\"\tO\n\n\"\tO\nWe\tO\nexpect\tO\nfrom\tO\nSyria\tT-1\n,\tO\nif\tO\nits\tO\nface\tO\nis\tO\nto\tO\npeace\tT-2\n,\tO\nthat\tO\nit\tO\nwill\tO\nanswer\tO\nIsrael\tB-LOC\n's\tO\nmessage\tO\nto\tO\nenter\tO\npeace\tO\nnegotiations\tT-4\nbecause\tO\nthat\tO\nis\tO\nour\tO\ngoal\tT-3\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\"\tO\n\nWe\tO\ndo\tO\nnot\tO\nwant\tT-0\na\tO\nwar\tO\n,\tO\nGod\tB-PER\nforbid\tT-1\n.\tO\n\nIsrael\tB-LOC\n's\tO\nChannel\tO\nTwo\tO\ntelevision\tO\nsaid\tT-2\nDamascus\tT-0\nhad\tO\nsent\tO\na\tO\n\"\tO\ncalming\tT-3\nsignal\tT-3\n\"\tO\nto\tO\nIsrael\tT-1\n.\tO\n\nIsrael\tT-1\n's\tO\nChannel\tB-ORG\nTwo\tI-ORG\ntelevision\tO\nsaid\tT-0\nDamascus\tT-2\nhad\tO\nsent\tO\na\tO\n\"\tO\ncalming\tO\nsignal\tO\n\"\tO\nto\tO\nIsrael\tO\n.\tO\n\nIsrael\tO\n's\tO\nChannel\tO\nTwo\tO\ntelevision\tO\nsaid\tT-0\nDamascus\tB-LOC\nhad\tT-2\nsent\tT-2\na\tO\n\"\tO\ncalming\tO\nsignal\tO\n\"\tO\nto\tO\nIsrael\tT-1\n.\tO\n\nIsrael\tT-0\n's\tO\nChannel\tO\nTwo\tO\ntelevision\tO\nsaid\tO\nDamascus\tT-1\nhad\tT-3\nsent\tT-3\na\tO\n\"\tO\ncalming\tT-2\nsignal\tT-2\n\"\tO\nto\tO\nIsrael\tB-LOC\n.\tO\n\nNetanyahu\tB-PER\nand\tO\nLevy\tO\n's\tO\nspokesmen\tT-1\nsaid\tT-0\nthey\tO\ncould\tO\nnot\tO\nconfirm\tO\nit\tO\n.\tO\n\nNetanyahu\tO\nand\tT-0\nLevy\tB-PER\n's\tO\nspokesmen\tO\nsaid\tT-1\nthey\tO\ncould\tO\nnot\tO\nconfirm\tO\nit\tO\n.\tO\n\nThe\tO\ntelevision\tO\nalso\tO\nsaid\tT-0\nthat\tO\nNetanyahu\tB-PER\nhad\tO\nsent\tO\nmessages\tO\nto\tO\nreassure\tO\nSyria\tT-1\nvia\tO\nCairo\tO\n,\tO\nthe\tO\nUnited\tT-2\nStates\tT-2\nand\tO\nMoscow\tO\n.\tO\n\nThe\tO\ntelevision\tT-0\nalso\tO\nsaid\tO\nthat\tO\nNetanyahu\tT-1\nhad\tO\nsent\tO\nmessages\tO\nto\tO\nreassure\tO\nSyria\tB-LOC\nvia\tO\nCairo\tO\n,\tO\nthe\tO\nUnited\tO\nStates\tO\nand\tO\nMoscow\tO\n.\tO\n\nThe\tO\ntelevision\tO\nalso\tO\nsaid\tT-2\nthat\tO\nNetanyahu\tO\nhad\tO\nsent\tO\nmessages\tO\nto\tO\nreassure\tT-3\nSyria\tT-1\nvia\tO\nCairo\tB-LOC\n,\tO\nthe\tO\nUnited\tT-4\nStates\tT-4\nand\tO\nMoscow\tT-5\n.\tO\n\nThe\tO\ntelevision\tT-1\nalso\tO\nsaid\tT-3\nthat\tO\nNetanyahu\tO\nhad\tO\nsent\tT-4\nmessages\tT-4\nto\tO\nreassure\tT-5\nSyria\tO\nvia\tO\nCairo\tO\n,\tO\nthe\tT-0\nUnited\tB-LOC\nStates\tI-LOC\nand\tO\nMoscow\tT-2\n.\tO\n\nThe\tO\ntelevision\tO\nalso\tO\nsaid\tO\nthat\tO\nNetanyahu\tO\nhad\tO\nsent\tO\nmessages\tT-1\nto\tO\nreassure\tO\nSyria\tO\nvia\tO\nCairo\tT-0\n,\tT-0\nthe\tT-0\nUnited\tT-0\nStates\tT-0\nand\tT-0\nMoscow\tB-LOC\n.\tO\n\nPolish\tB-MISC\ndiplomat\tT-0\ndenies\tT-1\nnurses\tT-2\nstranded\tO\nin\tO\nLibya\tO\n.\tO\n\nPolish\tT-0\ndiplomat\tT-1\ndenies\tT-2\nnurses\tO\nstranded\tO\nin\tO\nLibya\tB-LOC\n.\tO\n\nA\tO\nPolish\tB-MISC\ndiplomat\tT-1\non\tO\nThursday\tO\ndenied\tT-2\na\tO\nPolish\tT-0\ntabloid\tO\nreport\tO\nthis\tO\nweek\tO\nthat\tO\nLibya\tO\nwas\tO\nrefusing\tO\nexit\tO\nvisas\tO\nto\tO\n100\tO\nPolish\tO\nnurses\tO\ntrying\tO\nto\tO\nreturn\tO\nhome\tO\nafter\tO\nworking\tO\nin\tO\nthe\tO\nNorth\tO\nAfrican\tO\ncountry\tO\n.\tO\n\nA\tO\nPolish\tO\ndiplomat\tO\non\tO\nThursday\tO\ndenied\tT-0\na\tT-0\nPolish\tB-MISC\ntabloid\tT-1\nreport\tT-1\nthis\tO\nweek\tO\nthat\tO\nLibya\tO\nwas\tO\nrefusing\tT-2\nexit\tO\nvisas\tO\nto\tO\n100\tO\nPolish\tO\nnurses\tO\ntrying\tO\nto\tO\nreturn\tO\nhome\tO\nafter\tO\nworking\tO\nin\tO\nthe\tO\nNorth\tO\nAfrican\tO\ncountry\tO\n.\tO\n\nA\tO\nPolish\tT-1\ndiplomat\tO\non\tO\nThursday\tO\ndenied\tO\na\tO\nPolish\tO\ntabloid\tO\nreport\tO\nthis\tO\nweek\tO\nthat\tO\nLibya\tB-LOC\nwas\tO\nrefusing\tT-0\nexit\tO\nvisas\tO\nto\tO\n100\tO\nPolish\tO\nnurses\tO\ntrying\tO\nto\tO\nreturn\tO\nhome\tO\nafter\tO\nworking\tO\nin\tO\nthe\tO\nNorth\tT-2\nAfrican\tT-2\ncountry\tO\n.\tO\n\nA\tO\nPolish\tO\ndiplomat\tT-1\non\tO\nThursday\tO\ndenied\tO\na\tO\nPolish\tO\ntabloid\tO\nreport\tT-0\nthis\tO\nweek\tO\nthat\tO\nLibya\tO\nwas\tO\nrefusing\tO\nexit\tO\nvisas\tT-2\nto\tT-2\n100\tT-2\nPolish\tB-MISC\nnurses\tT-3\ntrying\tO\nto\tO\nreturn\tO\nhome\tO\nafter\tO\nworking\tO\nin\tO\nthe\tO\nNorth\tO\nAfrican\tO\ncountry\tO\n.\tO\n\nA\tO\nPolish\tT-1\ndiplomat\tO\non\tO\nThursday\tO\ndenied\tO\na\tO\nPolish\tT-3\ntabloid\tO\nreport\tO\nthis\tO\nweek\tO\nthat\tO\nLibya\tO\nwas\tO\nrefusing\tT-6\nexit\tT-6\nvisas\tT-6\nto\tO\n100\tO\nPolish\tT-2\nnurses\tT-5\ntrying\tO\nto\tO\nreturn\tT-7\nhome\tT-7\nafter\tO\nworking\tO\nin\tT-0\nthe\tT-0\nNorth\tB-MISC\nAfrican\tI-MISC\ncountry\tT-4\n.\tO\n\nUp\tO\nto\tO\ntoday\tO\n,\tO\nwe\tO\nhave\tO\nno\tO\nknowledge\tO\nof\tO\nany\tO\nnurse\tO\nstranded\tT-0\nor\tO\nkept\tT-1\nin\tO\nLibya\tB-LOC\nwithout\tO\nher\tO\nwill\tO\n,\tO\nand\tO\nwe\tO\nhave\tO\nnot\tO\nreceived\tO\nany\tO\ncomplaint\tO\n,\tO\n\"\tO\nthe\tO\nPolish\tT-2\nembassy\tT-2\n's\tT-2\ncharge\tO\nd'affaires\tO\nin\tO\nTripoli\tO\n,\tO\nTadeusz\tO\nAwdankiewicz\tO\n,\tO\ntold\tO\nReuters\tO\nby\tO\ntelephone\tO\n.\tO\n\nUp\tO\nto\tO\ntoday\tO\n,\tO\nwe\tO\nhave\tO\nno\tO\nknowledge\tO\nof\tO\nany\tO\nnurse\tT-0\nstranded\tO\nor\tO\nkept\tO\nin\tO\nLibya\tO\nwithout\tO\nher\tO\nwill\tO\n,\tO\nand\tO\nwe\tO\nhave\tO\nnot\tO\nreceived\tO\nany\tO\ncomplaint\tO\n,\tO\n\"\tO\nthe\tO\nPolish\tB-MISC\nembassy\tT-3\n's\tT-3\ncharge\tO\nd'affaires\tO\nin\tO\nTripoli\tT-1\n,\tO\nTadeusz\tO\nAwdankiewicz\tO\n,\tO\ntold\tO\nReuters\tO\nby\tO\ntelephone\tT-2\n.\tO\n\nUp\tO\nto\tO\ntoday\tO\n,\tO\nwe\tO\nhave\tO\nno\tO\nknowledge\tO\nof\tO\nany\tO\nnurse\tO\nstranded\tT-0\nor\tO\nkept\tO\nin\tT-1\nLibya\tT-2\nwithout\tO\nher\tO\nwill\tO\n,\tO\nand\tO\nwe\tO\nhave\tO\nnot\tO\nreceived\tO\nany\tO\ncomplaint\tO\n,\tO\n\"\tO\nthe\tO\nPolish\tT-3\nembassy\tO\n's\tO\ncharge\tO\nd'affaires\tO\nin\tT-5\nTripoli\tB-LOC\n,\tO\nTadeusz\tT-4\nAwdankiewicz\tT-4\n,\tO\ntold\tO\nReuters\tO\nby\tO\ntelephone\tO\n.\tO\n\nUp\tO\nto\tO\ntoday\tO\n,\tO\nwe\tT-0\nhave\tT-0\nno\tO\nknowledge\tO\nof\tO\nany\tO\nnurse\tT-1\nstranded\tO\nor\tO\nkept\tO\nin\tO\nLibya\tO\nwithout\tO\nher\tO\nwill\tO\n,\tO\nand\tO\nwe\tO\nhave\tO\nnot\tO\nreceived\tO\nany\tO\ncomplaint\tT-2\n,\tO\n\"\tO\nthe\tO\nPolish\tO\nembassy\tO\n's\tO\ncharge\tO\nd'affaires\tO\nin\tO\nTripoli\tT-3\n,\tO\nTadeusz\tB-PER\nAwdankiewicz\tI-PER\n,\tO\ntold\tO\nReuters\tO\nby\tO\ntelephone\tO\n.\tO\n\nUp\tO\nto\tO\ntoday\tO\n,\tO\nwe\tO\nhave\tO\nno\tO\nknowledge\tT-4\nof\tO\nany\tO\nnurse\tO\nstranded\tT-0\nor\tO\nkept\tT-1\nin\tO\nLibya\tT-3\nwithout\tO\nher\tO\nwill\tO\n,\tO\nand\tO\nwe\tO\nhave\tO\nnot\tO\nreceived\tO\nany\tO\ncomplaint\tO\n,\tO\n\"\tO\nthe\tO\nPolish\tO\nembassy\tO\n's\tO\ncharge\tO\nd'affaires\tO\nin\tO\nTripoli\tO\n,\tO\nTadeusz\tO\nAwdankiewicz\tO\n,\tO\ntold\tT-2\nReuters\tB-ORG\nby\tO\ntelephone\tO\n.\tO\n\nPoland\tB-LOC\n's\tT-0\nlabour\tO\nministry\tO\nsaid\tO\nthis\tO\nweek\tO\nit\tT-1\nwould\tO\nsend\tO\na\tO\nteam\tO\nto\tO\nLibya\tO\nto\tO\ninvestigate\tT-2\n,\tO\nbut\tO\nAwdankiewicz\tO\nsaid\tO\nthe\tO\nprobe\tO\nwas\tO\nprompted\tO\nby\tO\nsome\tO\nnurses\tO\ncomplaining\tO\nabout\tO\ntheir\tO\nwork\tO\nconditions\tO\nsuch\tO\nas\tO\nnon-payment\tO\nof\tO\ntheir\tO\nsalaries\tO\n.\tO\n\nPoland\tO\n's\tO\nlabour\tO\nministry\tO\nsaid\tO\nthis\tO\nweek\tO\nit\tO\nwould\tO\nsend\tO\na\tO\nteam\tO\nto\tO\nLibya\tB-LOC\nto\tO\ninvestigate\tT-0\n,\tO\nbut\tO\nAwdankiewicz\tO\nsaid\tO\nthe\tO\nprobe\tO\nwas\tO\nprompted\tO\nby\tO\nsome\tO\nnurses\tO\ncomplaining\tO\nabout\tO\ntheir\tO\nwork\tO\nconditions\tO\nsuch\tO\nas\tO\nnon-payment\tO\nof\tO\ntheir\tO\nsalaries\tO\n.\tO\n\nPoland\tO\n's\tO\nlabour\tT-2\nministry\tT-2\nsaid\tT-0\nthis\tO\nweek\tO\nit\tO\nwould\tO\nsend\tO\na\tO\nteam\tO\nto\tO\nLibya\tO\nto\tO\ninvestigate\tT-1\n,\tO\nbut\tO\nAwdankiewicz\tB-PER\nsaid\tO\nthe\tO\nprobe\tO\nwas\tO\nprompted\tO\nby\tO\nsome\tO\nnurses\tO\ncomplaining\tO\nabout\tO\ntheir\tO\nwork\tO\nconditions\tO\nsuch\tO\nas\tO\nnon-payment\tO\nof\tO\ntheir\tO\nsalaries\tO\n.\tO\n\nHe\tO\nsaid\tO\nthat\tO\nthere\tO\nare\tO\nan\tO\nestimated\tO\n800\tO\nPolish\tT-1\nnurses\tT-1\nworking\tO\nin\tT-0\nLibya\tB-LOC\n.\tO\n\nTwo\tT-0\nIranian\tB-MISC\nopposition\tT-1\nleaders\tT-2\nmeet\tO\nin\tO\nBaghdad\tT-3\n.\tO\n\nTwo\tO\nIranian\tO\nopposition\tT-1\nleaders\tO\nmeet\tT-0\nin\tT-0\nBaghdad\tB-LOC\n.\tO\n\nAn\tO\nIranian\tB-MISC\nexile\tT-1\ngroup\tT-0\nbased\tO\nin\tO\nIraq\tO\nvowed\tT-2\non\tO\nThursday\tO\nto\tO\nextend\tO\nsupport\tO\nto\tO\nIran\tO\n's\tO\nKurdish\tT-3\nrebels\tT-3\nafter\tO\nthey\tO\nwere\tO\nattacked\tO\nby\tO\nIranian\tO\ntroops\tO\ndeep\tO\ninside\tO\nIraq\tO\nlast\tO\nmonth\tO\n.\tO\n\nAn\tO\nIranian\tT-1\nexile\tT-1\ngroup\tT-1\nbased\tT-0\nin\tO\nIraq\tB-LOC\nvowed\tO\non\tO\nThursday\tO\nto\tO\nextend\tT-2\nsupport\tO\nto\tO\nIran\tO\n's\tO\nKurdish\tO\nrebels\tO\nafter\tO\nthey\tO\nwere\tO\nattacked\tT-3\nby\tO\nIranian\tO\ntroops\tO\ndeep\tO\ninside\tO\nIraq\tO\nlast\tO\nmonth\tO\n.\tO\n\nAn\tO\nIranian\tO\nexile\tO\ngroup\tO\nbased\tO\nin\tO\nIraq\tO\nvowed\tO\non\tO\nThursday\tO\nto\tO\nextend\tO\nsupport\tO\nto\tT-2\nIran\tB-LOC\n's\tO\nKurdish\tT-1\nrebels\tO\nafter\tO\nthey\tO\nwere\tO\nattacked\tO\nby\tO\nIranian\tO\ntroops\tO\ndeep\tO\ninside\tO\nIraq\tT-0\nlast\tO\nmonth\tO\n.\tO\n\nAn\tO\nIranian\tO\nexile\tO\ngroup\tO\nbased\tO\nin\tO\nIraq\tO\nvowed\tO\non\tO\nThursday\tO\nto\tO\nextend\tO\nsupport\tT-2\nto\tO\nIran\tT-1\n's\tO\nKurdish\tB-MISC\nrebels\tT-0\nafter\tT-0\nthey\tO\nwere\tO\nattacked\tO\nby\tO\nIranian\tO\ntroops\tO\ndeep\tO\ninside\tO\nIraq\tO\nlast\tO\nmonth\tO\n.\tO\n\nAn\tO\nIranian\tO\nexile\tO\ngroup\tO\nbased\tO\nin\tO\nIraq\tO\nvowed\tO\non\tO\nThursday\tO\nto\tO\nextend\tO\nsupport\tO\nto\tO\nIran\tO\n's\tO\nKurdish\tO\nrebels\tO\nafter\tO\nthey\tO\nwere\tO\nattacked\tT-0\nby\tO\nIranian\tB-MISC\ntroops\tT-1\ndeep\tT-1\ninside\tT-1\nIraq\tT-1\nlast\tO\nmonth\tO\n.\tO\n\nAn\tO\nIranian\tT-1\nexile\tO\ngroup\tO\nbased\tO\nin\tO\nIraq\tO\nvowed\tO\non\tO\nThursday\tO\nto\tO\nextend\tO\nsupport\tO\nto\tO\nIran\tO\n's\tO\nKurdish\tT-2\nrebels\tO\nafter\tO\nthey\tO\nwere\tO\nattacked\tO\nby\tO\nIranian\tO\ntroops\tO\ndeep\tT-3\ninside\tT-3\nIraq\tB-LOC\nlast\tO\nmonth\tO\n.\tO\n\nA\tO\nMujahideen\tT-3\nKhalq\tO\nstatement\tO\nsaid\tO\nits\tO\nleader\tT-0\nMassoud\tB-PER\nRajavi\tI-PER\nmet\tT-1\nin\tO\nBaghdad\tO\nthe\tO\nSecretary-General\tO\nof\tO\nthe\tO\nKurdistan\tO\nDemocratic\tT-2\nParty\tO\nof\tO\nIran\tO\n(\tO\nKDPI\tO\n)\tO\nHassan\tO\nRastegar\tO\non\tO\nWednesday\tO\nand\tO\nvoiced\tO\nhis\tO\nsupport\tO\nto\tO\nIran\tO\n's\tO\nrebel\tO\nKurds\tO\n.\tO\n\nA\tO\nMujahideen\tO\nKhalq\tO\nstatement\tO\nsaid\tT-3\nits\tO\nleader\tO\nMassoud\tT-2\nRajavi\tO\nmet\tT-0\nin\tO\nBaghdad\tB-LOC\nthe\tO\nSecretary-General\tT-1\nof\tO\nthe\tO\nKurdistan\tO\nDemocratic\tO\nParty\tO\nof\tO\nIran\tT-4\n(\tO\nKDPI\tO\n)\tO\nHassan\tO\nRastegar\tO\non\tO\nWednesday\tO\nand\tO\nvoiced\tO\nhis\tO\nsupport\tO\nto\tO\nIran\tO\n's\tO\nrebel\tO\nKurds\tO\n.\tO\n\nA\tT-0\nMujahideen\tT-0\nKhalq\tT-0\nstatement\tT-3\nsaid\tO\nits\tO\nleader\tO\nMassoud\tT-1\nRajavi\tT-1\nmet\tO\nin\tO\nBaghdad\tO\nthe\tO\nSecretary-General\tO\nof\tT-2\nthe\tT-2\nKurdistan\tB-ORG\nDemocratic\tI-ORG\nParty\tI-ORG\nof\tI-ORG\nIran\tI-ORG\n(\tO\nKDPI\tO\n)\tO\nHassan\tO\nRastegar\tO\non\tO\nWednesday\tO\nand\tO\nvoiced\tO\nhis\tO\nsupport\tO\nto\tO\nIran\tO\n's\tO\nrebel\tO\nKurds\tO\n.\tO\n\nA\tO\nMujahideen\tO\nKhalq\tO\nstatement\tO\nsaid\tO\nits\tO\nleader\tO\nMassoud\tO\nRajavi\tO\nmet\tO\nin\tO\nBaghdad\tO\nthe\tO\nSecretary-General\tO\nof\tO\nthe\tO\nKurdistan\tT-0\nDemocratic\tT-0\nParty\tT-0\nof\tO\nIran\tO\n(\tO\nKDPI\tB-ORG\n)\tO\nHassan\tO\nRastegar\tO\non\tO\nWednesday\tO\nand\tO\nvoiced\tO\nhis\tO\nsupport\tO\nto\tO\nIran\tO\n's\tO\nrebel\tO\nKurds\tO\n.\tO\n\nA\tO\nMujahideen\tO\nKhalq\tO\nstatement\tO\nsaid\tO\nits\tO\nleader\tO\nMassoud\tO\nRajavi\tO\nmet\tO\nin\tO\nBaghdad\tO\nthe\tO\nSecretary-General\tT-0\nof\tO\nthe\tO\nKurdistan\tT-4\nDemocratic\tT-4\nParty\tT-4\nof\tO\nIran\tT-1\n(\tO\nKDPI\tO\n)\tO\nHassan\tB-PER\nRastegar\tI-PER\non\tO\nWednesday\tO\nand\tO\nvoiced\tO\nhis\tO\nsupport\tT-2\nto\tO\nIran\tO\n's\tO\nrebel\tO\nKurds\tT-3\n.\tO\n\nA\tO\nMujahideen\tO\nKhalq\tO\nstatement\tO\nsaid\tT-1\nits\tO\nleader\tO\nMassoud\tO\nRajavi\tO\nmet\tO\nin\tO\nBaghdad\tO\nthe\tO\nSecretary-General\tO\nof\tO\nthe\tO\nKurdistan\tO\nDemocratic\tO\nParty\tO\nof\tO\nIran\tO\n(\tO\nKDPI\tO\n)\tO\nHassan\tO\nRastegar\tO\non\tO\nWednesday\tO\nand\tO\nvoiced\tT-2\nhis\tO\nsupport\tT-0\nto\tO\nIran\tB-LOC\n's\tO\nrebel\tT-3\nKurds\tT-3\n.\tO\n\nA\tO\nMujahideen\tO\nKhalq\tO\nstatement\tO\nsaid\tO\nits\tO\nleader\tO\nMassoud\tO\nRajavi\tO\nmet\tO\nin\tO\nBaghdad\tO\nthe\tO\nSecretary-General\tO\nof\tO\nthe\tO\nKurdistan\tO\nDemocratic\tO\nParty\tO\nof\tO\nIran\tO\n(\tO\nKDPI\tO\n)\tO\nHassan\tO\nRastegar\tO\non\tO\nWednesday\tO\nand\tO\nvoiced\tO\nhis\tO\nsupport\tT-1\nto\tO\nIran\tT-0\n's\tT-0\nrebel\tT-0\nKurds\tB-MISC\n.\tO\n\n\"\tO\nRajavi\tB-MISC\nemphasised\tT-0\nthat\tO\nthe\tO\nIranian\tT-1\nResistance\tT-1\nwould\tO\ncontinue\tO\nto\tO\nstand\tO\nside\tO\nby\tO\nside\tO\nwith\tO\ntheir\tO\nKurdish\tT-2\ncompatriots\tT-2\nand\tO\nthe\tO\nresistance\tO\nmovement\tO\nin\tO\nIranian\tT-3\nKurdistan\tT-3\n,\tO\n\"\tO\nit\tO\nsaid\tT-4\n.\tO\n\n\"\tO\nRajavi\tT-1\nemphasised\tO\nthat\tO\nthe\tO\nIranian\tB-MISC\nResistance\tT-2\nwould\tO\ncontinue\tO\nto\tT-0\nstand\tT-0\nside\tO\nby\tO\nside\tO\nwith\tO\ntheir\tO\nKurdish\tO\ncompatriots\tO\nand\tO\nthe\tO\nresistance\tO\nmovement\tT-3\nin\tO\nIranian\tO\nKurdistan\tO\n,\tO\n\"\tO\nit\tO\nsaid\tO\n.\tO\n\n\"\tO\nRajavi\tT-1\nemphasised\tO\nthat\tO\nthe\tO\nIranian\tT-0\nResistance\tB-ORG\nwould\tO\ncontinue\tO\nto\tO\nstand\tO\nside\tO\nby\tO\nside\tO\nwith\tO\ntheir\tO\nKurdish\tO\ncompatriots\tO\nand\tO\nthe\tO\nresistance\tO\nmovement\tO\nin\tO\nIranian\tO\nKurdistan\tO\n,\tO\n\"\tO\nit\tO\nsaid\tO\n.\tO\n\n\"\tO\nRajavi\tO\nemphasised\tO\nthat\tO\nthe\tO\nIranian\tO\nResistance\tO\nwould\tO\ncontinue\tO\nto\tO\nstand\tO\nside\tO\nby\tO\nside\tO\nwith\tO\ntheir\tO\nKurdish\tB-MISC\ncompatriots\tT-1\nand\tO\nthe\tO\nresistance\tT-2\nmovement\tT-2\nin\tO\nIranian\tO\nKurdistan\tO\n,\tO\n\"\tO\nit\tO\nsaid\tT-0\n.\tO\n\n\"\tO\nRajavi\tO\nemphasised\tO\nthat\tO\nthe\tO\nIranian\tO\nResistance\tO\nwould\tO\ncontinue\tO\nto\tO\nstand\tT-3\nside\tT-3\nby\tT-3\nside\tT-3\nwith\tO\ntheir\tO\nKurdish\tO\ncompatriots\tO\nand\tO\nthe\tO\nresistance\tO\nmovement\tT-2\nin\tT-0\nIranian\tB-LOC\nKurdistan\tI-LOC\n,\tO\n\"\tO\nit\tT-1\nsaid\tT-1\n.\tO\n\nA\tO\nspokesman\tO\nfor\tO\nthe\tO\ngroup\tO\nsaid\tT-1\nthe\tO\nmeeting\tO\n\"\tO\nsignals\tO\na\tO\nnew\tO\nlevel\tO\nof\tO\ncooperation\tT-0\nbetween\tO\nMujahideen\tB-ORG\nKhalq\tI-ORG\nand\tO\nthe\tO\nIranian\tO\nKurdish\tO\noppositions\tT-2\n\"\tO\n.\tO\n\nA\tO\nspokesman\tO\nfor\tO\nthe\tO\ngroup\tO\nsaid\tO\nthe\tO\nmeeting\tO\n\"\tO\nsignals\tO\na\tO\nnew\tO\nlevel\tO\nof\tO\ncooperation\tT-0\nbetween\tO\nMujahideen\tT-1\nKhalq\tT-1\nand\tT-1\nthe\tT-1\nIranian\tB-MISC\nKurdish\tI-MISC\noppositions\tT-2\n\"\tO\n.\tO\n\nIran\tB-LOC\nheavily\tO\nbombarded\tO\ntargets\tT-1\nin\tO\nnorthern\tO\nIraq\tT-0\nin\tO\nJuly\tO\nin\tO\npursuit\tO\nof\tO\nKDPI\tT-2\nguerrillas\tT-2\nbased\tT-2\nin\tO\nIraqi\tO\nKurdish\tO\nareas\tO\noutside\tO\nthe\tO\ncontrol\tO\nof\tO\nthe\tO\ngovernment\tO\nin\tO\nBaghdad\tO\n.\tO\n\nIran\tT-0\nheavily\tO\nbombarded\tO\ntargets\tO\nin\tO\nnorthern\tO\nIraq\tB-LOC\nin\tO\nJuly\tO\nin\tO\npursuit\tO\nof\tO\nKDPI\tO\nguerrillas\tO\nbased\tO\nin\tO\nIraqi\tO\nKurdish\tO\nareas\tO\noutside\tO\nthe\tO\ncontrol\tO\nof\tO\nthe\tO\ngovernment\tO\nin\tO\nBaghdad\tO\n.\tT-1\n\nIran\tO\nheavily\tO\nbombarded\tO\ntargets\tO\nin\tO\nnorthern\tO\nIraq\tO\nin\tO\nJuly\tO\nin\tO\npursuit\tO\nof\tO\nKDPI\tB-ORG\nguerrillas\tT-1\nbased\tT-0\nin\tO\nIraqi\tO\nKurdish\tO\nareas\tO\noutside\tO\nthe\tO\ncontrol\tO\nof\tO\nthe\tO\ngovernment\tO\nin\tO\nBaghdad\tO\n.\tO\n\nIran\tO\nheavily\tO\nbombarded\tT-0\ntargets\tO\nin\tO\nnorthern\tO\nIraq\tT-3\nin\tO\nJuly\tO\nin\tO\npursuit\tT-1\nof\tO\nKDPI\tO\nguerrillas\tO\nbased\tT-2\nin\tO\nIraqi\tB-MISC\nKurdish\tI-MISC\nareas\tO\noutside\tO\nthe\tO\ncontrol\tO\nof\tO\nthe\tO\ngovernment\tO\nin\tO\nBaghdad\tO\n.\tO\n\nIran\tT-0\nheavily\tO\nbombarded\tT-1\ntargets\tO\nin\tO\nnorthern\tO\nIraq\tO\nin\tO\nJuly\tO\nin\tO\npursuit\tO\nof\tO\nKDPI\tO\nguerrillas\tT-2\nbased\tO\nin\tO\nIraqi\tO\nKurdish\tO\nareas\tT-3\noutside\tO\nthe\tO\ncontrol\tO\nof\tO\nthe\tO\ngovernment\tT-4\nin\tO\nBaghdad\tB-LOC\n.\tO\n\nIraqi\tB-MISC\nKurdish\tI-MISC\nareas\tO\nbordering\tT-0\nIran\tO\nare\tO\nunder\tO\nthe\tO\ncontrol\tO\nof\tO\nguerrillas\tO\nof\tO\nthe\tO\nIraqi\tO\nKurdish\tO\nPatriotic\tO\nUnion\tO\nof\tO\nKurdistan\tO\n(\tO\nPUK\tO\n)\tO\ngroup\tO\n.\tO\n\nIraqi\tT-1\nKurdish\tT-1\nareas\tT-1\nbordering\tT-1\nIran\tB-LOC\nare\tO\nunder\tO\nthe\tO\ncontrol\tO\nof\tO\nguerrillas\tO\nof\tO\nthe\tO\nIraqi\tO\nKurdish\tO\nPatriotic\tO\nUnion\tT-2\nof\tO\nKurdistan\tO\n(\tO\nPUK\tO\n)\tO\ngroup\tT-0\n.\tO\n\nIraqi\tO\nKurdish\tO\nareas\tO\nbordering\tO\nIran\tO\nare\tO\nunder\tO\nthe\tO\ncontrol\tO\nof\tO\nguerrillas\tO\nof\tT-1\nthe\tT-1\nIraqi\tB-ORG\nKurdish\tI-ORG\nPatriotic\tI-ORG\nUnion\tI-ORG\nof\tI-ORG\nKurdistan\tI-ORG\n(\tO\nPUK\tO\n)\tO\ngroup\tT-0\n.\tO\n\nIraqi\tT-0\nKurdish\tT-0\nareas\tO\nbordering\tO\nIran\tO\nare\tO\nunder\tO\nthe\tO\ncontrol\tO\nof\tO\nguerrillas\tO\nof\tO\nthe\tO\nIraqi\tO\nKurdish\tO\nPatriotic\tO\nUnion\tO\nof\tO\nKurdistan\tO\n(\tO\nPUK\tB-ORG\n)\tO\ngroup\tO\n.\tO\n\nPUK\tB-ORG\nand\tO\nIraq\tO\n's\tO\nKurdistan\tO\nDemocratic\tT-4\nParty\tO\n(\tO\nKDP\tO\n)\tO\nthe\tO\ntwo\tO\nmain\tO\nIraqi\tO\nKurdish\tT-3\nfactions\tT-3\n,\tO\nhave\tO\nhad\tO\nnorthern\tO\nIraq\tO\nunder\tO\ntheir\tO\ncontrol\tT-0\nsince\tO\nIraqi\tO\nforces\tO\nwere\tO\nousted\tT-1\nfrom\tO\nKuwait\tT-2\nin\tO\nthe\tO\n1991\tO\nGulf\tO\nWar\tO\n.\tO\n\nPUK\tT-3\nand\tT-2\nIraq\tB-LOC\n's\tO\nKurdistan\tO\nDemocratic\tO\nParty\tO\n(\tO\nKDP\tO\n)\tO\nthe\tO\ntwo\tO\nmain\tO\nIraqi\tO\nKurdish\tO\nfactions\tO\n,\tO\nhave\tO\nhad\tO\nnorthern\tO\nIraq\tO\nunder\tO\ntheir\tO\ncontrol\tT-0\nsince\tO\nIraqi\tO\nforces\tO\nwere\tO\nousted\tT-1\nfrom\tO\nKuwait\tO\nin\tO\nthe\tO\n1991\tO\nGulf\tO\nWar\tO\n.\tO\n\nPUK\tT-1\nand\tO\nIraq\tO\n's\tO\nKurdistan\tB-ORG\nDemocratic\tI-ORG\nParty\tI-ORG\n(\tO\nKDP\tT-0\n)\tO\nthe\tO\ntwo\tO\nmain\tO\nIraqi\tO\nKurdish\tO\nfactions\tO\n,\tO\nhave\tO\nhad\tO\nnorthern\tO\nIraq\tO\nunder\tO\ntheir\tO\ncontrol\tO\nsince\tO\nIraqi\tO\nforces\tO\nwere\tO\nousted\tO\nfrom\tO\nKuwait\tO\nin\tO\nthe\tO\n1991\tO\nGulf\tO\nWar\tO\n.\tO\n\nPUK\tT-1\nand\tO\nIraq\tO\n's\tO\nKurdistan\tT-2\nDemocratic\tT-2\nParty\tT-2\n(\tO\nKDP\tB-ORG\n)\tO\nthe\tO\ntwo\tO\nmain\tO\nIraqi\tO\nKurdish\tT-0\nfactions\tT-0\n,\tO\nhave\tO\nhad\tO\nnorthern\tO\nIraq\tO\nunder\tO\ntheir\tO\ncontrol\tO\nsince\tO\nIraqi\tO\nforces\tO\nwere\tO\nousted\tO\nfrom\tO\nKuwait\tO\nin\tO\nthe\tO\n1991\tO\nGulf\tO\nWar\tO\n.\tO\n\nPUK\tT-5\nand\tO\nIraq\tT-3\n's\tO\nKurdistan\tT-6\nDemocratic\tO\nParty\tT-7\n(\tO\nKDP\tO\n)\tO\nthe\tO\ntwo\tT-0\nmain\tT-0\nIraqi\tB-MISC\nKurdish\tI-MISC\nfactions\tT-1\n,\tO\nhave\tO\nhad\tO\nnorthern\tO\nIraq\tO\nunder\tT-2\ntheir\tT-2\ncontrol\tT-2\nsince\tO\nIraqi\tO\nforces\tO\nwere\tO\nousted\tO\nfrom\tO\nKuwait\tO\nin\tO\nthe\tO\n1991\tO\nGulf\tT-4\nWar\tT-4\n.\tO\n\nPUK\tT-0\nand\tO\nIraq\tT-1\n's\tO\nKurdistan\tO\nDemocratic\tO\nParty\tO\n(\tO\nKDP\tO\n)\tO\nthe\tO\ntwo\tO\nmain\tO\nIraqi\tO\nKurdish\tO\nfactions\tO\n,\tO\nhave\tO\nhad\tO\nnorthern\tT-3\nIraq\tB-LOC\nunder\tO\ntheir\tO\ncontrol\tO\nsince\tO\nIraqi\tO\nforces\tO\nwere\tO\nousted\tO\nfrom\tO\nKuwait\tT-2\nin\tO\nthe\tO\n1991\tO\nGulf\tO\nWar\tO\n.\tO\n\nPUK\tT-0\nand\tO\nIraq\tO\n's\tO\nKurdistan\tT-1\nDemocratic\tT-1\nParty\tT-1\n(\tO\nKDP\tO\n)\tO\nthe\tO\ntwo\tO\nmain\tO\nIraqi\tO\nKurdish\tO\nfactions\tO\n,\tO\nhave\tO\nhad\tO\nnorthern\tT-2\nIraq\tT-2\nunder\tO\ntheir\tO\ncontrol\tO\nsince\tT-3\nIraqi\tB-MISC\nforces\tO\nwere\tO\nousted\tT-4\nfrom\tO\nKuwait\tO\nin\tO\nthe\tO\n1991\tO\nGulf\tO\nWar\tO\n.\tO\n\nPUK\tO\nand\tO\nIraq\tO\n's\tO\nKurdistan\tO\nDemocratic\tO\nParty\tO\n(\tO\nKDP\tO\n)\tO\nthe\tO\ntwo\tO\nmain\tO\nIraqi\tO\nKurdish\tO\nfactions\tO\n,\tO\nhave\tO\nhad\tO\nnorthern\tO\nIraq\tO\nunder\tO\ntheir\tO\ncontrol\tT-0\nsince\tO\nIraqi\tO\nforces\tO\nwere\tO\nousted\tT-1\nfrom\tO\nKuwait\tB-LOC\nin\tO\nthe\tO\n1991\tO\nGulf\tO\nWar\tO\n.\tO\n\nPUK\tO\nand\tO\nIraq\tO\n's\tO\nKurdistan\tO\nDemocratic\tO\nParty\tO\n(\tO\nKDP\tO\n)\tO\nthe\tO\ntwo\tO\nmain\tO\nIraqi\tO\nKurdish\tO\nfactions\tO\n,\tO\nhave\tO\nhad\tO\nnorthern\tO\nIraq\tO\nunder\tO\ntheir\tO\ncontrol\tT-1\nsince\tO\nIraqi\tO\nforces\tT-0\nwere\tO\nousted\tT-2\nfrom\tO\nKuwait\tO\nin\tO\nthe\tO\n1991\tO\nGulf\tB-MISC\nWar\tI-MISC\n.\tO\n\nClashes\tT-0\nbetween\tO\nthe\tO\ntwo\tO\nparties\tT-2\nbroke\tO\nout\tO\nat\tO\nthe\tO\nweekend\tO\nin\tO\nthe\tO\nmost\tO\nserious\tO\nfighting\tO\nsince\tO\na\tO\nU.S.-sponsored\tB-MISC\nceasefire\tT-1\nlast\tO\nyear\tO\n.\tO\n\nMujahideen\tB-ORG\nKhalq\tI-ORG\nsaid\tT-0\nIranian\tT-1\ntroops\tO\nhad\tO\nalso\tO\nbeen\tO\nshelling\tO\nKDP\tO\npositions\tO\nin\tO\nQasri\tO\nregion\tO\nin\tO\nSuleimaniya\tO\nprovince\tO\nnear\tO\nthe\tO\nIranian\tO\nborder\tO\nover\tO\nthe\tO\nlast\tO\ntwo\tO\ndays\tO\n.\tO\n\nMujahideen\tT-3\nKhalq\tO\nsaid\tT-0\nIranian\tB-MISC\ntroops\tT-1\nhad\tO\nalso\tO\nbeen\tO\nshelling\tT-2\nKDP\tO\npositions\tO\nin\tO\nQasri\tO\nregion\tO\nin\tO\nSuleimaniya\tO\nprovince\tO\nnear\tO\nthe\tO\nIranian\tO\nborder\tO\nover\tO\nthe\tO\nlast\tO\ntwo\tO\ndays\tO\n.\tO\n\nMujahideen\tO\nKhalq\tO\nsaid\tT-0\nIranian\tO\ntroops\tO\nhad\tO\nalso\tO\nbeen\tO\nshelling\tO\nKDP\tB-ORG\npositions\tT-1\nin\tO\nQasri\tO\nregion\tO\nin\tO\nSuleimaniya\tO\nprovince\tO\nnear\tO\nthe\tO\nIranian\tO\nborder\tO\nover\tO\nthe\tO\nlast\tO\ntwo\tO\ndays\tO\n.\tO\n\nMujahideen\tO\nKhalq\tO\nsaid\tO\nIranian\tO\ntroops\tO\nhad\tO\nalso\tO\nbeen\tO\nshelling\tO\nKDP\tO\npositions\tO\nin\tO\nQasri\tB-LOC\nregion\tT-0\nin\tO\nSuleimaniya\tO\nprovince\tO\nnear\tO\nthe\tO\nIranian\tO\nborder\tT-1\nover\tO\nthe\tO\nlast\tO\ntwo\tO\ndays\tO\n.\tO\n\nMujahideen\tO\nKhalq\tO\nsaid\tO\nIranian\tO\ntroops\tO\nhad\tO\nalso\tO\nbeen\tO\nshelling\tO\nKDP\tT-0\npositions\tT-0\nin\tO\nQasri\tT-2\nregion\tT-2\nin\tT-4\nSuleimaniya\tB-LOC\nprovince\tT-5\nnear\tT-1\nthe\tT-1\nIranian\tT-3\nborder\tT-3\nover\tO\nthe\tO\nlast\tO\ntwo\tO\ndays\tO\n.\tO\n\nMujahideen\tT-1\nKhalq\tT-1\nsaid\tO\nIranian\tO\ntroops\tO\nhad\tO\nalso\tO\nbeen\tO\nshelling\tO\nKDP\tO\npositions\tO\nin\tO\nQasri\tO\nregion\tO\nin\tO\nSuleimaniya\tO\nprovince\tT-0\nnear\tO\nthe\tO\nIranian\tB-MISC\nborder\tT-2\nover\tT-2\nthe\tT-2\nlast\tT-2\ntwo\tT-2\ndays\tT-2\n.\tT-2\n\nIt\tO\nsaid\tO\nabout\tO\n100\tT-0\nIraqi\tB-MISC\nKurds\tI-MISC\nwere\tO\nkilled\tO\nor\tO\nwounded\tT-1\nin\tO\nthe\tO\nattack\tO\n.\tO\n\nBoth\tT-0\nIran\tB-LOC\nand\tO\nTurkey\tO\nmount\tO\nair\tO\nand\tO\nland\tO\nstrikes\tO\nat\tO\ntargets\tT-1\nin\tO\nnorthern\tO\nIraq\tO\nin\tO\npursuit\tO\nof\tO\ntheir\tO\nown\tO\nKurdish\tO\nrebels\tO\n.\tO\n\nBoth\tO\nIran\tT-1\nand\tO\nTurkey\tB-LOC\nmount\tT-3\nair\tO\nand\tO\nland\tO\nstrikes\tO\nat\tO\ntargets\tO\nin\tO\nnorthern\tO\nIraq\tT-2\nin\tO\npursuit\tT-4\nof\tO\ntheir\tO\nown\tO\nKurdish\tT-0\nrebels\tT-0\n.\tO\n\nBoth\tO\nIran\tO\nand\tO\nTurkey\tO\nmount\tT-0\nair\tO\nand\tO\nland\tO\nstrikes\tO\nat\tO\ntargets\tO\nin\tO\nnorthern\tO\nIraq\tB-LOC\nin\tO\npursuit\tT-1\nof\tO\ntheir\tO\nown\tO\nKurdish\tT-2\nrebels\tO\n.\tO\n\nBoth\tO\nIran\tO\nand\tO\nTurkey\tO\nmount\tO\nair\tO\nand\tO\nland\tO\nstrikes\tO\nat\tO\ntargets\tO\nin\tO\nnorthern\tO\nIraq\tO\nin\tO\npursuit\tT-0\nof\tO\ntheir\tO\nown\tT-1\nKurdish\tB-MISC\nrebels\tT-2\n.\tO\n\nA\tO\nU.S.-led\tB-MISC\nair\tO\nforce\tO\nin\tO\nsouthern\tO\nTurkey\tO\nprotects\tT-0\nIraqi\tT-1\nKurds\tT-1\nfrom\tO\npossible\tO\nattacks\tO\nby\tO\nBaghdad\tO\ntroops\tO\n.\tO\n\nA\tO\nU.S.-led\tO\nair\tO\nforce\tO\nin\tT-3\nsouthern\tT-3\nTurkey\tB-LOC\nprotects\tT-1\nIraqi\tO\nKurds\tT-0\nfrom\tO\npossible\tO\nattacks\tO\nby\tO\nBaghdad\tT-2\ntroops\tT-2\n.\tO\n\nA\tO\nU.S.-led\tT-0\nair\tO\nforce\tO\nin\tO\nsouthern\tO\nTurkey\tO\nprotects\tT-3\nIraqi\tB-MISC\nKurds\tI-MISC\nfrom\tT-2\npossible\tT-2\nattacks\tT-2\nby\tO\nBaghdad\tO\ntroops\tO\n.\tT-3\n\nA\tO\nU.S.-led\tO\nair\tO\nforce\tO\nin\tO\nsouthern\tO\nTurkey\tT-1\nprotects\tO\nIraqi\tT-2\nKurds\tT-2\nfrom\tO\npossible\tO\nattacks\tO\nby\tO\nBaghdad\tB-LOC\ntroops\tT-0\n.\tO\n\nSaudi\tB-MISC\nriyal\tO\nrates\tT-1\nsteady\tT-0\nin\tO\nquiet\tO\nsummer\tO\ntrade\tO\n.\tO\n\nThe\tO\nspot\tT-1\nSaudi\tB-MISC\nriyal\tT-2\nagainst\tO\nthe\tO\ndollar\tT-0\nand\tO\nriyal\tO\ninterbank\tO\ndeposit\tO\nrates\tO\nwere\tO\nmainly\tO\nsteady\tO\nthis\tO\nweek\tO\nin\tO\nquiet\tO\nsummer\tO\ntrade\tO\n,\tO\ndealers\tO\nin\tO\nthe\tO\nkingdom\tO\nsaid\tO\n.\tO\n\n\"\tO\nThere\tO\nwere\tO\nno\tO\nchanges\tT-0\nin\tO\nSaudi\tB-MISC\nriyal\tO\nrates\tT-1\n.\tO\n\nOne-month\tB-MISC\ninterbank\tT-1\ndeposits\tT-0\nwere\tO\nat\tO\n5-1/2\tO\n,\tO\n3/8\tO\npercent\tO\n,\tO\nthree\tO\nmonths\tO\nwere\tO\n5-5/8\tO\n,\tO\n1/2\tO\npercent\tO\nand\tO\nsix\tO\nmonths\tO\nwere\tO\n5-3/4\tO\n,\tO\n5/8\tO\npercent\tO\n.\tO\n\nOne-year\tB-MISC\nfunds\tT-1\nwere\tT-0\nat\tO\nsix\tO\n,\tO\n5-7/8\tO\npercent\tO\n.\tO\n\nIsrael\tB-LOC\napproves\tT-0\nArafat\tO\n's\tO\nflight\tO\nto\tO\nWest\tO\nBank\tT-1\n.\tT-1\n\nIsrael\tT-1\napproves\tO\nArafat\tB-PER\n's\tO\nflight\tT-0\nto\tO\nWest\tO\nBank\tO\n.\tO\n\nIsrael\tO\napproves\tO\nArafat\tO\n's\tO\nflight\tT-0\nto\tO\nWest\tB-LOC\nBank\tI-LOC\n.\tO\n\nIsrael\tB-LOC\ngave\tO\nPalestinian\tO\nPresident\tO\nYasser\tT-0\nArafat\tT-0\npermission\tO\non\tO\nThursday\tO\nto\tO\nfly\tO\nover\tO\nits\tO\nterritory\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\n,\tO\nending\tO\na\tO\nbrief\tO\nIsraeli-PLO\tO\ncrisis\tO\n,\tO\nan\tO\nArafat\tO\nadviser\tO\nsaid\tO\n.\tO\n\nIsrael\tT-4\ngave\tT-2\nPalestinian\tB-MISC\nPresident\tO\nYasser\tT-0\nArafat\tT-0\npermission\tT-3\non\tO\nThursday\tO\nto\tO\nfly\tO\nover\tO\nits\tO\nterritory\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\n,\tO\nending\tO\na\tO\nbrief\tO\nIsraeli-PLO\tT-1\ncrisis\tO\n,\tO\nan\tO\nArafat\tO\nadviser\tO\nsaid\tO\n.\tT-1\n\nIsrael\tO\ngave\tT-1\nPalestinian\tO\nPresident\tT-0\nYasser\tB-PER\nArafat\tI-PER\npermission\tT-2\non\tO\nThursday\tO\nto\tO\nfly\tO\nover\tO\nits\tO\nterritory\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\n,\tO\nending\tO\na\tO\nbrief\tO\nIsraeli-PLO\tO\ncrisis\tO\n,\tO\nan\tO\nArafat\tO\nadviser\tO\nsaid\tO\n.\tO\n\nIsrael\tO\ngave\tT-4\nPalestinian\tT-1\nPresident\tT-1\nYasser\tT-1\nArafat\tT-1\npermission\tT-5\non\tO\nThursday\tO\nto\tO\nfly\tT-6\nover\tO\nits\tT-0\nterritory\tT-2\nto\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\n,\tO\nending\tT-3\na\tO\nbrief\tO\nIsraeli-PLO\tO\ncrisis\tO\n,\tO\nan\tO\nArafat\tO\nadviser\tO\nsaid\tO\n.\tO\n\nIsrael\tO\ngave\tO\nPalestinian\tO\nPresident\tO\nYasser\tO\nArafat\tT-0\npermission\tO\non\tO\nThursday\tO\nto\tO\nfly\tO\nover\tO\nits\tO\nterritory\tT-1\nto\tO\nthe\tO\nWest\tO\nBank\tO\n,\tO\nending\tO\na\tT-2\nbrief\tT-2\nIsraeli-PLO\tB-MISC\ncrisis\tT-3\n,\tO\nan\tO\nArafat\tO\nadviser\tO\nsaid\tO\n.\tO\n\nIsrael\tO\ngave\tT-0\nPalestinian\tO\nPresident\tO\nYasser\tO\nArafat\tO\npermission\tO\non\tO\nThursday\tO\nto\tO\nfly\tO\nover\tO\nits\tO\nterritory\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\n,\tO\nending\tT-2\na\tO\nbrief\tO\nIsraeli-PLO\tO\ncrisis\tO\n,\tO\nan\tT-1\nArafat\tB-PER\nadviser\tO\nsaid\tO\n.\tO\n\nThe\tT-0\npresident\tT-0\n's\tO\naircraft\tO\nhas\tO\nreceived\tO\npermission\tO\nto\tO\npass\tT-3\nthrough\tT-3\nIsraeli\tB-MISC\nairspace\tT-4\nbut\tO\nthe\tT-1\npresident\tT-1\nis\tO\nnot\tO\nexpected\tO\nto\tO\ntravel\tO\nto\tO\nthe\tO\nWest\tT-2\nBank\tT-2\nbefore\tO\nMonday\tO\n,\tO\n\"\tO\nNabil\tO\nAbu\tO\nRdainah\tO\ntold\tO\nReuters\tO\n.\tO\n\nThe\tO\npresident\tT-1\n's\tO\naircraft\tO\nhas\tO\nreceived\tO\npermission\tO\nto\tO\npass\tO\nthrough\tO\nIsraeli\tO\nairspace\tO\nbut\tO\nthe\tO\npresident\tO\nis\tO\nnot\tO\nexpected\tO\nto\tO\ntravel\tT-0\nto\tT-0\nthe\tT-0\nWest\tB-LOC\nBank\tI-LOC\nbefore\tO\nMonday\tO\n,\tO\n\"\tO\nNabil\tO\nAbu\tO\nRdainah\tO\ntold\tO\nReuters\tO\n.\tO\n\nThe\tO\npresident\tO\n's\tO\naircraft\tO\nhas\tO\nreceived\tO\npermission\tT-1\nto\tO\npass\tO\nthrough\tO\nIsraeli\tO\nairspace\tO\nbut\tO\nthe\tO\npresident\tO\nis\tO\nnot\tO\nexpected\tO\nto\tO\ntravel\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nbefore\tO\nMonday\tO\n,\tO\n\"\tO\nNabil\tB-PER\nAbu\tI-PER\nRdainah\tI-PER\ntold\tT-0\nReuters\tO\n.\tO\n\nThe\tO\npresident\tT-2\n's\tT-2\naircraft\tT-2\nhas\tO\nreceived\tO\npermission\tO\nto\tO\npass\tO\nthrough\tO\nIsraeli\tT-0\nairspace\tT-0\nbut\tO\nthe\tO\npresident\tO\nis\tO\nnot\tO\nexpected\tO\nto\tO\ntravel\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nbefore\tO\nMonday\tO\n,\tO\n\"\tO\nNabil\tT-3\nAbu\tT-3\nRdainah\tT-3\ntold\tT-1\nReuters\tB-ORG\n.\tO\n\nArafat\tB-PER\nhad\tO\nbeen\tO\nscheduled\tT-1\nto\tO\nmeet\tT-0\nformer\tT-2\nIsraeli\tO\nprime\tO\nminister\tO\nShimon\tO\nPeres\tO\nin\tO\nthe\tO\nWest\tO\nBank\tO\ntown\tO\nof\tO\nRamallah\tO\non\tO\nThursday\tO\nbut\tO\nthe\tO\nvenue\tO\nwas\tO\nchanged\tO\nto\tO\nGaza\tO\nafter\tO\nIsrael\tO\ndenied\tO\nflight\tO\nclearance\tT-3\nto\tO\nthe\tO\nPalestinian\tO\nleader\tO\n's\tO\nhelicopters\tO\n.\tO\n\nArafat\tO\nhad\tO\nbeen\tO\nscheduled\tO\nto\tO\nmeet\tO\nformer\tT-1\nIsraeli\tB-MISC\nprime\tT-2\nminister\tO\nShimon\tT-3\nPeres\tO\nin\tO\nthe\tO\nWest\tO\nBank\tO\ntown\tO\nof\tO\nRamallah\tO\non\tO\nThursday\tO\nbut\tO\nthe\tO\nvenue\tT-0\nwas\tO\nchanged\tO\nto\tO\nGaza\tO\nafter\tO\nIsrael\tO\ndenied\tO\nflight\tO\nclearance\tO\nto\tO\nthe\tO\nPalestinian\tO\nleader\tO\n's\tO\nhelicopters\tO\n.\tO\n\nArafat\tT-1\nhad\tO\nbeen\tO\nscheduled\tO\nto\tO\nmeet\tO\nformer\tO\nIsraeli\tO\nprime\tT-0\nminister\tT-0\nShimon\tB-PER\nPeres\tI-PER\nin\tO\nthe\tO\nWest\tO\nBank\tO\ntown\tO\nof\tO\nRamallah\tO\non\tO\nThursday\tO\nbut\tO\nthe\tO\nvenue\tO\nwas\tO\nchanged\tO\nto\tO\nGaza\tO\nafter\tO\nIsrael\tO\ndenied\tO\nflight\tO\nclearance\tO\nto\tO\nthe\tO\nPalestinian\tO\nleader\tO\n's\tO\nhelicopters\tO\n.\tO\n\nArafat\tO\nhad\tO\nbeen\tO\nscheduled\tO\nto\tO\nmeet\tO\nformer\tO\nIsraeli\tO\nprime\tO\nminister\tO\nShimon\tO\nPeres\tO\nin\tT-1\nthe\tT-1\nWest\tB-LOC\nBank\tI-LOC\ntown\tO\nof\tO\nRamallah\tO\non\tO\nThursday\tO\nbut\tO\nthe\tO\nvenue\tT-0\nwas\tO\nchanged\tO\nto\tO\nGaza\tO\nafter\tO\nIsrael\tO\ndenied\tO\nflight\tO\nclearance\tO\nto\tO\nthe\tO\nPalestinian\tO\nleader\tO\n's\tO\nhelicopters\tO\n.\tO\n\nArafat\tO\nhad\tO\nbeen\tO\nscheduled\tO\nto\tO\nmeet\tO\nformer\tO\nIsraeli\tT-0\nprime\tO\nminister\tO\nShimon\tO\nPeres\tO\nin\tO\nthe\tO\nWest\tT-1\nBank\tT-1\ntown\tT-3\nof\tT-3\nRamallah\tB-LOC\non\tO\nThursday\tO\nbut\tO\nthe\tO\nvenue\tO\nwas\tO\nchanged\tO\nto\tO\nGaza\tT-2\nafter\tO\nIsrael\tO\ndenied\tO\nflight\tO\nclearance\tO\nto\tO\nthe\tO\nPalestinian\tO\nleader\tO\n's\tO\nhelicopters\tO\n.\tO\n\nArafat\tO\nhad\tO\nbeen\tO\nscheduled\tT-3\nto\tO\nmeet\tO\nformer\tO\nIsraeli\tO\nprime\tO\nminister\tO\nShimon\tO\nPeres\tO\nin\tO\nthe\tO\nWest\tO\nBank\tO\ntown\tO\nof\tO\nRamallah\tT-2\non\tO\nThursday\tO\nbut\tO\nthe\tO\nvenue\tT-0\nwas\tT-1\nchanged\tT-1\nto\tO\nGaza\tB-LOC\nafter\tO\nIsrael\tO\ndenied\tO\nflight\tO\nclearance\tO\nto\tO\nthe\tO\nPalestinian\tO\nleader\tO\n's\tO\nhelicopters\tO\n.\tO\n\nArafat\tT-0\nhad\tO\nbeen\tO\nscheduled\tO\nto\tO\nmeet\tT-2\nformer\tO\nIsraeli\tO\nprime\tO\nminister\tO\nShimon\tO\nPeres\tO\nin\tO\nthe\tO\nWest\tO\nBank\tO\ntown\tO\nof\tO\nRamallah\tO\non\tO\nThursday\tO\nbut\tO\nthe\tO\nvenue\tO\nwas\tO\nchanged\tT-3\nto\tO\nGaza\tO\nafter\tO\nIsrael\tB-LOC\ndenied\tT-1\nflight\tO\nclearance\tO\nto\tO\nthe\tO\nPalestinian\tO\nleader\tO\n's\tO\nhelicopters\tO\n.\tO\n\nArafat\tO\nhad\tO\nbeen\tO\nscheduled\tT-2\nto\tO\nmeet\tO\nformer\tO\nIsraeli\tT-0\nprime\tT-0\nminister\tT-0\nShimon\tT-0\nPeres\tT-0\nin\tO\nthe\tO\nWest\tO\nBank\tO\ntown\tO\nof\tO\nRamallah\tO\non\tO\nThursday\tO\nbut\tO\nthe\tO\nvenue\tO\nwas\tO\nchanged\tO\nto\tO\nGaza\tO\nafter\tO\nIsrael\tO\ndenied\tT-1\nflight\tT-1\nclearance\tT-1\nto\tO\nthe\tO\nPalestinian\tB-MISC\nleader\tO\n's\tO\nhelicopters\tO\n.\tO\n\nPalestinian\tB-MISC\nofficials\tT-1\naccused\tT-0\nright-wing\tT-2\nPrime\tO\nMinister\tO\nBenjamin\tO\nNetanyahu\tO\nof\tO\ntrying\tO\nto\tO\nstop\tO\nthe\tO\nRamallah\tO\nmeeting\tO\nby\tO\nkeeping\tO\nArafat\tO\ngrounded\tO\n.\tO\n\nPalestinian\tO\nofficials\tO\naccused\tT-0\nright-wing\tO\nPrime\tO\nMinister\tT-1\nBenjamin\tB-PER\nNetanyahu\tI-PER\nof\tO\ntrying\tO\nto\tO\nstop\tO\nthe\tO\nRamallah\tO\nmeeting\tO\nby\tO\nkeeping\tO\nArafat\tO\ngrounded\tO\n.\tO\n\nPalestinian\tO\nofficials\tO\naccused\tO\nright-wing\tO\nPrime\tT-0\nMinister\tT-0\nBenjamin\tT-0\nNetanyahu\tT-0\nof\tO\ntrying\tO\nto\tO\nstop\tO\nthe\tO\nRamallah\tB-LOC\nmeeting\tO\nby\tO\nkeeping\tO\nArafat\tT-1\ngrounded\tO\n.\tO\n\nPalestinian\tO\nofficials\tO\naccused\tT-1\nright-wing\tO\nPrime\tO\nMinister\tO\nBenjamin\tO\nNetanyahu\tO\nof\tO\ntrying\tO\nto\tO\nstop\tO\nthe\tO\nRamallah\tO\nmeeting\tT-0\nby\tO\nkeeping\tO\nArafat\tB-PER\ngrounded\tO\n.\tO\n\nArafat\tB-PER\nsubsequently\tT-2\ncancelled\tT-1\na\tO\nmeeting\tO\nbetween\tO\nIsraeli\tT-3\nand\tO\nPLO\tO\nofficials\tO\n,\tO\non\tO\ncivilian\tT-4\naffairs\tT-4\n,\tO\nat\tO\nthe\tO\nAllenby\tO\nBridge\tO\ncrossing\tO\nbetween\tT-0\nJordan\tO\nand\tO\nthe\tO\nWest\tO\nBank\tO\n.\tO\n\nArafat\tO\nsubsequently\tO\ncancelled\tO\na\tO\nmeeting\tT-1\nbetween\tT-0\nIsraeli\tB-MISC\nand\tO\nPLO\tT-2\nofficials\tO\n,\tO\non\tO\ncivilian\tO\naffairs\tO\n,\tO\nat\tO\nthe\tO\nAllenby\tO\nBridge\tO\ncrossing\tO\nbetween\tO\nJordan\tO\nand\tO\nthe\tO\nWest\tO\nBank\tO\n.\tO\n\nArafat\tT-0\nsubsequently\tO\ncancelled\tO\na\tO\nmeeting\tO\nbetween\tO\nIsraeli\tT-1\nand\tO\nPLO\tB-ORG\nofficials\tO\n,\tO\non\tO\ncivilian\tT-2\naffairs\tT-2\n,\tO\nat\tO\nthe\tO\nAllenby\tO\nBridge\tO\ncrossing\tO\nbetween\tO\nJordan\tO\nand\tO\nthe\tO\nWest\tO\nBank\tO\n.\tO\n\nArafat\tO\nsubsequently\tT-0\ncancelled\tO\na\tO\nmeeting\tO\nbetween\tO\nIsraeli\tO\nand\tO\nPLO\tO\nofficials\tO\n,\tO\non\tO\ncivilian\tO\naffairs\tO\n,\tO\nat\tO\nthe\tO\nAllenby\tB-LOC\nBridge\tI-LOC\ncrossing\tT-1\nbetween\tO\nJordan\tO\nand\tO\nthe\tO\nWest\tO\nBank\tO\n.\tO\n\nArafat\tO\nsubsequently\tO\ncancelled\tO\na\tO\nmeeting\tO\nbetween\tO\nIsraeli\tO\nand\tO\nPLO\tO\nofficials\tO\n,\tO\non\tO\ncivilian\tO\naffairs\tO\n,\tO\nat\tO\nthe\tO\nAllenby\tT-0\nBridge\tT-2\ncrossing\tT-3\nbetween\tT-3\nJordan\tB-LOC\nand\tO\nthe\tO\nWest\tT-1\nBank\tT-1\n.\tT-2\n\nArafat\tO\nsubsequently\tO\ncancelled\tO\na\tO\nmeeting\tO\nbetween\tO\nIsraeli\tO\nand\tO\nPLO\tO\nofficials\tO\n,\tO\non\tO\ncivilian\tO\naffairs\tO\n,\tO\nat\tO\nthe\tO\nAllenby\tO\nBridge\tO\ncrossing\tT-0\nbetween\tO\nJordan\tO\nand\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\n.\tO\n\nAbu\tB-PER\nRdainah\tI-PER\nsaid\tT-0\nArafat\tT-1\nhad\tO\ndecided\tT-3\nagainst\tT-3\nflying\tT-3\nto\tO\nthe\tO\nWest\tO\nBank\tO\non\tO\nThursday\tO\n,\tO\nafter\tO\nIsrael\tO\nlifted\tO\nthe\tO\nban\tT-2\n,\tO\nbecause\tO\nhe\tO\nhad\tO\na\tO\nbusy\tT-4\nschedule\tT-4\nin\tT-4\nGaza\tT-4\nand\tO\nwould\tO\nnot\tT-5\nbe\tT-5\nfree\tT-5\nuntil\tT-5\nMonday\tT-5\n.\tO\n\nAbu\tT-1\nRdainah\tT-1\nsaid\tO\nArafat\tB-PER\nhad\tO\ndecided\tT-5\nagainst\tO\nflying\tO\nto\tO\nthe\tO\nWest\tT-2\nBank\tT-2\non\tO\nThursday\tO\n,\tO\nafter\tO\nIsrael\tT-3\nlifted\tO\nthe\tO\nban\tO\n,\tO\nbecause\tO\nhe\tT-0\nhad\tT-0\na\tO\nbusy\tO\nschedule\tO\nin\tO\nGaza\tT-4\nand\tO\nwould\tO\nnot\tO\nbe\tO\nfree\tO\nuntil\tO\nMonday\tO\n.\tO\n\nAbu\tT-3\nRdainah\tT-3\nsaid\tT-0\nArafat\tO\nhad\tO\ndecided\tT-1\nagainst\tO\nflying\tT-4\nto\tT-4\nthe\tT-4\nWest\tB-LOC\nBank\tI-LOC\non\tO\nThursday\tO\n,\tO\nafter\tO\nIsrael\tO\nlifted\tO\nthe\tO\nban\tT-2\n,\tO\nbecause\tO\nhe\tO\nhad\tO\na\tO\nbusy\tO\nschedule\tO\nin\tO\nGaza\tO\nand\tO\nwould\tO\nnot\tO\nbe\tO\nfree\tO\nuntil\tO\nMonday\tO\n.\tO\n\nAbu\tO\nRdainah\tO\nsaid\tO\nArafat\tO\nhad\tO\ndecided\tT-1\nagainst\tO\nflying\tT-0\nto\tT-0\nthe\tO\nWest\tT-2\nBank\tT-2\non\tO\nThursday\tO\n,\tO\nafter\tO\nIsrael\tB-LOC\nlifted\tT-4\nthe\tT-4\nban\tT-4\n,\tO\nbecause\tO\nhe\tO\nhad\tO\na\tO\nbusy\tO\nschedule\tO\nin\tO\nGaza\tO\nand\tO\nwould\tO\nnot\tO\nbe\tO\nfree\tO\nuntil\tT-3\nMonday\tT-3\n.\tO\n\nAbu\tT-3\nRdainah\tT-3\nsaid\tT-1\nArafat\tT-4\nhad\tO\ndecided\tO\nagainst\tO\nflying\tT-0\nto\tO\nthe\tO\nWest\tT-2\nBank\tT-2\non\tO\nThursday\tO\n,\tO\nafter\tO\nIsrael\tT-5\nlifted\tO\nthe\tO\nban\tO\n,\tO\nbecause\tO\nhe\tO\nhad\tO\na\tO\nbusy\tO\nschedule\tO\nin\tO\nGaza\tB-LOC\nand\tO\nwould\tO\nnot\tO\nbe\tO\nfree\tO\nuntil\tO\nMonday\tO\n.\tO\n\nArafat\tB-PER\nto\tO\nmeet\tT-0\nPeres\tO\nin\tO\nGaza\tO\nafter\tO\nflight\tO\nban\tO\n.\tO\n\nArafat\tO\nto\tO\nmeet\tT-0\nPeres\tB-PER\nin\tO\nGaza\tT-1\nafter\tO\nflight\tO\nban\tO\n.\tO\n\nArafat\tT-1\nto\tO\nmeet\tO\nPeres\tO\nin\tO\nGaza\tB-LOC\nafter\tO\nflight\tT-0\nban\tO\n.\tO\n\nYasser\tB-PER\nArafat\tI-PER\nwill\tO\nmeet\tT-0\nShimon\tT-1\nPeres\tT-1\nin\tO\nGaza\tO\non\tO\nThursday\tO\nafter\tO\nPalestinians\tO\nsaid\tO\nthe\tO\nright-wing\tO\nIsraeli\tO\ngovernment\tO\nhad\tO\nbarred\tT-2\nthe\tT-2\nPalestinian\tT-2\nleader\tT-2\nfrom\tO\nflying\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nfor\tO\ntalks\tO\nwith\tO\nthe\tO\nformer\tO\nprime\tO\nminister\tO\n.\tO\n\nYasser\tO\nArafat\tO\nwill\tT-1\nmeet\tT-3\nShimon\tB-PER\nPeres\tI-PER\nin\tO\nGaza\tT-0\non\tO\nThursday\tO\nafter\tO\nPalestinians\tO\nsaid\tO\nthe\tO\nright-wing\tO\nIsraeli\tO\ngovernment\tO\nhad\tO\nbarred\tT-4\nthe\tO\nPalestinian\tO\nleader\tO\nfrom\tO\nflying\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nfor\tO\ntalks\tO\nwith\tO\nthe\tO\nformer\tT-2\nprime\tT-2\nminister\tT-2\n.\tO\n\nYasser\tO\nArafat\tO\nwill\tO\nmeet\tO\nShimon\tT-2\nPeres\tT-2\nin\tO\nGaza\tB-LOC\non\tO\nThursday\tO\nafter\tO\nPalestinians\tT-0\nsaid\tO\nthe\tO\nright-wing\tO\nIsraeli\tO\ngovernment\tO\nhad\tO\nbarred\tO\nthe\tO\nPalestinian\tO\nleader\tO\nfrom\tO\nflying\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nfor\tO\ntalks\tO\nwith\tO\nthe\tO\nformer\tT-1\nprime\tT-1\nminister\tT-1\n.\tO\n\nYasser\tT-0\nArafat\tT-0\nwill\tO\nmeet\tT-4\nShimon\tT-1\nPeres\tT-1\nin\tO\nGaza\tT-7\non\tO\nThursday\tO\nafter\tO\nPalestinians\tB-MISC\nsaid\tT-5\nthe\tO\nright-wing\tO\nIsraeli\tT-2\ngovernment\tO\nhad\tO\nbarred\tO\nthe\tO\nPalestinian\tT-3\nleader\tO\nfrom\tO\nflying\tT-6\nto\tO\nthe\tO\nWest\tO\nBank\tO\nfor\tO\ntalks\tO\nwith\tO\nthe\tO\nformer\tO\nprime\tO\nminister\tO\n.\tO\n\nYasser\tT-1\nArafat\tT-1\nwill\tO\nmeet\tT-2\nShimon\tO\nPeres\tO\nin\tO\nGaza\tO\non\tO\nThursday\tO\nafter\tO\nPalestinians\tO\nsaid\tT-3\nthe\tO\nright-wing\tT-0\nIsraeli\tB-MISC\ngovernment\tO\nhad\tO\nbarred\tT-4\nthe\tO\nPalestinian\tT-5\nleader\tT-5\nfrom\tO\nflying\tO\nto\tO\nthe\tO\nWest\tT-6\nBank\tT-6\nfor\tO\ntalks\tO\nwith\tO\nthe\tO\nformer\tO\nprime\tT-7\nminister\tT-7\n.\tO\n\nYasser\tO\nArafat\tO\nwill\tO\nmeet\tO\nShimon\tO\nPeres\tO\nin\tO\nGaza\tO\non\tO\nThursday\tO\nafter\tO\nPalestinians\tO\nsaid\tT-2\nthe\tT-1\nright-wing\tT-1\nIsraeli\tT-1\ngovernment\tT-1\nhad\tT-1\nbarred\tT-1\nthe\tT-1\nPalestinian\tB-MISC\nleader\tT-0\nfrom\tO\nflying\tT-3\nto\tO\nthe\tO\nWest\tO\nBank\tO\nfor\tO\ntalks\tO\nwith\tO\nthe\tO\nformer\tO\nprime\tO\nminister\tO\n.\tO\n\nYasser\tT-0\nArafat\tT-0\nwill\tO\nmeet\tT-6\nShimon\tT-1\nPeres\tT-1\nin\tO\nGaza\tT-2\non\tO\nThursday\tO\nafter\tO\nPalestinians\tT-3\nsaid\tO\nthe\tO\nright-wing\tO\nIsraeli\tT-4\ngovernment\tT-4\nhad\tO\nbarred\tO\nthe\tO\nPalestinian\tT-5\nleader\tO\nfrom\tO\nflying\tT-7\nto\tT-8\nthe\tT-8\nWest\tB-LOC\nBank\tI-LOC\nfor\tO\ntalks\tO\nwith\tO\nthe\tO\nformer\tO\nprime\tO\nminister\tO\n.\tO\n\n\"\tO\nThe\tO\nmeeting\tT-3\nbetween\tT-3\nPeres\tB-PER\nand\tO\nArafat\tO\nwill\tO\ntake\tO\nplace\tO\nat\tO\nErez\tO\ncheckpoint\tO\nin\tO\nGaza\tO\nand\tO\nnot\tO\nin\tO\nRamallah\tO\nas\tO\nplanned\tT-1\n,\tO\n\"\tO\nPeres\tO\n'\tO\noffice\tO\nsaid\tT-2\n.\tO\n\n\"\tO\nThe\tO\nmeeting\tT-0\nbetween\tO\nPeres\tT-1\nand\tO\nArafat\tB-PER\nwill\tO\ntake\tO\nplace\tO\nat\tO\nErez\tO\ncheckpoint\tO\nin\tO\nGaza\tO\nand\tO\nnot\tO\nin\tO\nRamallah\tO\nas\tO\nplanned\tO\n,\tO\n\"\tO\nPeres\tO\n'\tO\noffice\tO\nsaid\tT-2\n.\tO\n\n\"\tO\nThe\tO\nmeeting\tO\nbetween\tO\nPeres\tT-2\nand\tO\nArafat\tT-3\nwill\tO\ntake\tO\nplace\tO\nat\tT-1\nErez\tB-LOC\ncheckpoint\tO\nin\tO\nGaza\tT-4\nand\tO\nnot\tO\nin\tO\nRamallah\tT-5\nas\tO\nplanned\tT-0\n,\tO\n\"\tO\nPeres\tO\n'\tO\noffice\tO\nsaid\tO\n.\tO\n\n\"\tO\nThe\tO\nmeeting\tO\nbetween\tO\nPeres\tO\nand\tO\nArafat\tO\nwill\tO\ntake\tO\nplace\tO\nat\tO\nErez\tT-0\ncheckpoint\tT-0\nin\tT-2\nGaza\tB-LOC\nand\tT-3\nnot\tT-3\nin\tT-3\nRamallah\tO\nas\tO\nplanned\tO\n,\tO\n\"\tO\nPeres\tO\n'\tO\noffice\tT-1\nsaid\tO\n.\tO\n\n\"\tO\nThe\tO\nmeeting\tO\nbetween\tO\nPeres\tO\nand\tO\nArafat\tO\nwill\tO\ntake\tO\nplace\tO\nat\tO\nErez\tO\ncheckpoint\tO\nin\tO\nGaza\tO\nand\tO\nnot\tT-0\nin\tT-0\nRamallah\tB-LOC\nas\tO\nplanned\tO\n,\tO\n\"\tO\nPeres\tO\n'\tO\noffice\tO\nsaid\tO\n.\tO\n\n\"\tO\nThe\tO\nmeeting\tT-0\nbetween\tO\nPeres\tO\nand\tO\nArafat\tO\nwill\tO\ntake\tT-1\nplace\tT-2\nat\tO\nErez\tO\ncheckpoint\tO\nin\tO\nGaza\tO\nand\tO\nnot\tO\nin\tO\nRamallah\tO\nas\tO\nplanned\tT-3\n,\tO\n\"\tO\nPeres\tB-PER\n'\tO\noffice\tO\nsaid\tT-4\n.\tO\n\nPalestinian\tB-MISC\nofficials\tT-4\nsaid\tO\nthe\tO\nIsraeli\tT-1\ngovernment\tT-1\nhad\tO\nbarred\tO\nArafat\tT-2\nfrom\tO\noverflying\tO\nIsrael\tO\nin\tO\na\tO\nPalestinian\tO\nhelicopter\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nin\tO\nan\tO\nattempt\tO\nto\tO\nbar\tO\nthe\tO\nmeeting\tO\nwith\tO\nPeres\tT-3\n.\tO\n\nPalestinian\tO\nofficials\tT-1\nsaid\tT-0\nthe\tT-0\nIsraeli\tB-MISC\ngovernment\tT-2\nhad\tO\nbarred\tO\nArafat\tO\nfrom\tO\noverflying\tO\nIsrael\tO\nin\tO\na\tO\nPalestinian\tO\nhelicopter\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nin\tO\nan\tO\nattempt\tO\nto\tO\nbar\tO\nthe\tO\nmeeting\tO\nwith\tO\nPeres\tO\n.\tO\n\nPalestinian\tT-2\nofficials\tT-2\nsaid\tT-3\nthe\tO\nIsraeli\tO\ngovernment\tT-0\nhad\tT-4\nbarred\tT-4\nArafat\tB-PER\nfrom\tO\noverflying\tO\nIsrael\tO\nin\tO\na\tO\nPalestinian\tT-1\nhelicopter\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nin\tO\nan\tO\nattempt\tO\nto\tO\nbar\tO\nthe\tO\nmeeting\tO\nwith\tO\nPeres\tO\n.\tO\n\nPalestinian\tT-0\nofficials\tT-0\nsaid\tO\nthe\tO\nIsraeli\tT-3\ngovernment\tO\nhad\tO\nbarred\tO\nArafat\tT-1\nfrom\tO\noverflying\tT-4\nIsrael\tB-LOC\nin\tO\na\tO\nPalestinian\tT-2\nhelicopter\tT-2\nto\tO\nthe\tO\nWest\tO\nBank\tO\nin\tO\nan\tO\nattempt\tO\nto\tO\nbar\tO\nthe\tO\nmeeting\tO\nwith\tO\nPeres\tO\n.\tO\n\nPalestinian\tT-0\nofficials\tO\nsaid\tT-5\nthe\tO\nIsraeli\tT-1\ngovernment\tO\nhad\tO\nbarred\tO\nArafat\tT-2\nfrom\tO\noverflying\tT-3\nIsrael\tO\nin\tO\na\tO\nPalestinian\tB-MISC\nhelicopter\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nin\tO\nan\tO\nattempt\tT-4\nto\tO\nbar\tO\nthe\tO\nmeeting\tO\nwith\tO\nPeres\tO\n.\tO\n\nPalestinian\tT-2\nofficials\tT-2\nsaid\tO\nthe\tO\nIsraeli\tO\ngovernment\tO\nhad\tO\nbarred\tO\nArafat\tT-3\nfrom\tO\noverflying\tO\nIsrael\tO\nin\tO\na\tO\nPalestinian\tO\nhelicopter\tT-1\nto\tT-0\nthe\tT-0\nWest\tB-LOC\nBank\tI-LOC\nin\tO\nan\tO\nattempt\tO\nto\tO\nbar\tO\nthe\tO\nmeeting\tO\nwith\tO\nPeres\tO\n.\tO\n\nPalestinian\tO\nofficials\tO\nsaid\tT-0\nthe\tO\nIsraeli\tO\ngovernment\tT-1\nhad\tO\nbarred\tT-2\nArafat\tT-3\nfrom\tO\noverflying\tO\nIsrael\tO\nin\tO\na\tO\nPalestinian\tO\nhelicopter\tO\nto\tO\nthe\tO\nWest\tO\nBank\tO\nin\tO\nan\tO\nattempt\tO\nto\tO\nbar\tO\nthe\tO\nmeeting\tO\nwith\tO\nPeres\tB-PER\n.\tO\n\nIsraeli\tB-MISC\nPrime\tT-3\nMinister\tT-3\nBenjamin\tT-4\nNetanyahu\tT-4\nhas\tO\naccused\tT-0\nopposition\tO\nleader\tO\nPeres\tO\n,\tO\nwho\tO\nhe\tO\ndefeated\tT-1\nin\tO\nMay\tT-2\nelections\tT-2\n,\tO\nof\tO\ntrying\tO\nto\tO\nundermine\tO\nhis\tO\nLikud\tO\ngovernment\tO\n's\tO\nauthority\tO\nto\tO\nconduct\tO\npeace\tO\ntalks\tO\n.\tO\n\nIsraeli\tO\nPrime\tO\nMinister\tO\nBenjamin\tB-PER\nNetanyahu\tI-PER\nhas\tO\naccused\tO\nopposition\tO\nleader\tO\nPeres\tT-0\n,\tO\nwho\tO\nhe\tO\ndefeated\tO\nin\tO\nMay\tO\nelections\tO\n,\tO\nof\tO\ntrying\tO\nto\tO\nundermine\tO\nhis\tO\nLikud\tT-1\ngovernment\tO\n's\tO\nauthority\tO\nto\tO\nconduct\tO\npeace\tO\ntalks\tO\n.\tO\n\nIsraeli\tO\nPrime\tO\nMinister\tO\nBenjamin\tO\nNetanyahu\tO\nhas\tO\naccused\tT-2\nopposition\tT-0\nleader\tT-1\nPeres\tB-PER\n,\tO\nwho\tO\nhe\tO\ndefeated\tT-3\nin\tO\nMay\tO\nelections\tO\n,\tO\nof\tO\ntrying\tO\nto\tO\nundermine\tO\nhis\tO\nLikud\tO\ngovernment\tO\n's\tO\nauthority\tO\nto\tO\nconduct\tO\npeace\tO\ntalks\tO\n.\tO\n\nIsraeli\tO\nPrime\tT-0\nMinister\tT-0\nBenjamin\tO\nNetanyahu\tO\nhas\tO\naccused\tT-1\nopposition\tO\nleader\tO\nPeres\tO\n,\tO\nwho\tO\nhe\tO\ndefeated\tO\nin\tO\nMay\tO\nelections\tO\n,\tO\nof\tO\ntrying\tO\nto\tO\nundermine\tO\nhis\tO\nLikud\tB-ORG\ngovernment\tO\n's\tO\nauthority\tT-2\nto\tO\nconduct\tO\npeace\tO\ntalks\tO\n.\tO\n\nAfghan\tB-MISC\nUAE\tT-0\nembassy\tT-0\nsays\tT-1\nTaleban\tO\nguards\tO\ngoing\tO\nhome\tO\n.\tO\n\nAfghan\tO\nUAE\tB-LOC\nembassy\tO\nsays\tO\nTaleban\tT-0\nguards\tT-0\ngoing\tO\nhome\tO\n.\tO\n\nAfghan\tO\nUAE\tO\nembassy\tO\nsays\tO\nTaleban\tB-MISC\nguards\tT-0\ngoing\tO\nhome\tO\n.\tO\n\nThree\tO\nAfghan\tB-MISC\nguards\tT-0\nbrought\tO\nto\tO\nthe\tO\nUnited\tT-1\nArab\tT-1\nEmirates\tT-1\nlast\tO\nweek\tO\nby\tO\nRussian\tT-2\nhostages\tT-2\nwho\tO\nescaped\tO\nfrom\tO\nthe\tO\nTaleban\tO\nmilitia\tO\nwill\tO\nreturn\tO\nto\tO\nAfghanistan\tO\nin\tO\na\tO\nfew\tO\ndays\tO\n,\tO\nthe\tO\nAfghan\tO\nembassy\tO\nin\tO\nAbu\tO\nDhabi\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThree\tO\nAfghan\tO\nguards\tO\nbrought\tT-1\nto\tO\nthe\tO\nUnited\tB-LOC\nArab\tI-LOC\nEmirates\tI-LOC\nlast\tO\nweek\tO\nby\tO\nRussian\tO\nhostages\tO\nwho\tO\nescaped\tO\nfrom\tT-0\nthe\tO\nTaleban\tO\nmilitia\tO\nwill\tO\nreturn\tO\nto\tO\nAfghanistan\tO\nin\tO\na\tO\nfew\tO\ndays\tO\n,\tO\nthe\tO\nAfghan\tO\nembassy\tO\nin\tO\nAbu\tO\nDhabi\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThree\tO\nAfghan\tO\nguards\tO\nbrought\tO\nto\tO\nthe\tO\nUnited\tO\nArab\tO\nEmirates\tT-0\nlast\tO\nweek\tO\nby\tO\nRussian\tB-MISC\nhostages\tT-3\nwho\tO\nescaped\tO\nfrom\tO\nthe\tO\nTaleban\tO\nmilitia\tO\nwill\tO\nreturn\tT-2\nto\tO\nAfghanistan\tO\nin\tO\na\tO\nfew\tO\ndays\tO\n,\tO\nthe\tO\nAfghan\tO\nembassy\tO\nin\tO\nAbu\tO\nDhabi\tO\nsaid\tT-1\non\tO\nThursday\tO\n.\tO\n\nThree\tO\nAfghan\tO\nguards\tO\nbrought\tO\nto\tO\nthe\tO\nUnited\tT-1\nArab\tT-1\nEmirates\tT-1\nlast\tO\nweek\tO\nby\tO\nRussian\tT-2\nhostages\tO\nwho\tO\nescaped\tO\nfrom\tO\nthe\tO\nTaleban\tB-MISC\nmilitia\tO\nwill\tO\nreturn\tT-0\nto\tO\nAfghanistan\tO\nin\tO\na\tO\nfew\tO\ndays\tO\n,\tO\nthe\tO\nAfghan\tO\nembassy\tO\nin\tO\nAbu\tO\nDhabi\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThree\tO\nAfghan\tT-0\nguards\tT-0\nbrought\tT-1\nto\tO\nthe\tO\nUnited\tT-3\nArab\tT-3\nEmirates\tT-3\nlast\tO\nweek\tO\nby\tO\nRussian\tO\nhostages\tO\nwho\tO\nescaped\tO\nfrom\tO\nthe\tO\nTaleban\tT-4\nmilitia\tO\nwill\tO\nreturn\tT-2\nto\tO\nAfghanistan\tB-LOC\nin\tO\na\tO\nfew\tO\ndays\tO\n,\tO\nthe\tO\nAfghan\tO\nembassy\tO\nin\tO\nAbu\tO\nDhabi\tO\nsaid\tT-5\non\tO\nThursday\tO\n.\tO\n\nThree\tO\nAfghan\tO\nguards\tO\nbrought\tO\nto\tO\nthe\tO\nUnited\tT-2\nArab\tT-2\nEmirates\tT-2\nlast\tO\nweek\tO\nby\tO\nRussian\tO\nhostages\tO\nwho\tO\nescaped\tO\nfrom\tO\nthe\tO\nTaleban\tT-4\nmilitia\tO\nwill\tO\nreturn\tO\nto\tO\nAfghanistan\tO\nin\tO\na\tO\nfew\tO\ndays\tO\n,\tO\nthe\tO\nAfghan\tB-MISC\nembassy\tT-1\nin\tO\nAbu\tT-3\nDhabi\tT-3\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThree\tO\nAfghan\tO\nguards\tO\nbrought\tO\nto\tO\nthe\tO\nUnited\tO\nArab\tO\nEmirates\tO\nlast\tO\nweek\tO\nby\tO\nRussian\tO\nhostages\tO\nwho\tO\nescaped\tO\nfrom\tO\nthe\tO\nTaleban\tO\nmilitia\tO\nwill\tO\nreturn\tO\nto\tO\nAfghanistan\tO\nin\tO\na\tO\nfew\tO\ndays\tO\n,\tO\nthe\tO\nAfghan\tO\nembassy\tT-1\nin\tT-1\nAbu\tB-LOC\nDhabi\tI-LOC\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nOur\tO\nambassador\tO\nis\tO\nin\tO\ntouch\tT-0\nwith\tO\nthe\tO\nUAE\tB-LOC\nforeign\tO\nministry\tO\n.\tO\n\nTheir\tO\nreturn\tT-0\nto\tT-2\nAfghanistan\tB-LOC\nwill\tO\ntake\tT-1\nplace\tT-1\nin\tO\ntwo\tO\nor\tO\nthree\tO\ndays\tO\n,\tO\n\"\tO\nan\tO\nembassy\tO\nofficial\tO\nsaid\tO\n.\tO\n\nThe\tO\nthree\tO\nIslamic\tB-MISC\nTaleban\tI-MISC\nguards\tT-0\nwere\tO\noverpowered\tO\nby\tO\nseven\tO\nRussian\tO\naircrew\tO\nwho\tO\nescaped\tO\nto\tO\nUAE\tO\nstate\tO\nSharjah\tO\nlast\tO\nFriday\tO\non\tO\nboard\tO\ntheir\tO\nown\tO\naircraft\tO\nafter\tO\na\tO\nyear\tO\nin\tO\nthe\tO\ncaptivity\tO\nof\tO\nTaleban\tT-1\nmilitia\tT-1\nin\tO\nKandahar\tO\nin\tO\nsouthern\tO\nAfghanistan\tO\n.\tO\n\nThe\tO\nthree\tO\nIslamic\tO\nTaleban\tO\nguards\tO\nwere\tO\noverpowered\tT-1\nby\tO\nseven\tO\nRussian\tB-MISC\naircrew\tT-0\nwho\tO\nescaped\tT-2\nto\tO\nUAE\tO\nstate\tO\nSharjah\tO\nlast\tO\nFriday\tO\non\tO\nboard\tO\ntheir\tO\nown\tO\naircraft\tO\nafter\tO\na\tO\nyear\tO\nin\tO\nthe\tO\ncaptivity\tO\nof\tO\nTaleban\tT-3\nmilitia\tT-3\nin\tO\nKandahar\tO\nin\tO\nsouthern\tO\nAfghanistan\tO\n.\tO\n\nThe\tO\nthree\tO\nIslamic\tO\nTaleban\tT-2\nguards\tT-0\nwere\tO\noverpowered\tT-1\nby\tO\nseven\tO\nRussian\tO\naircrew\tO\nwho\tO\nescaped\tT-3\nto\tT-3\nUAE\tB-LOC\nstate\tO\nSharjah\tO\nlast\tO\nFriday\tO\non\tO\nboard\tO\ntheir\tO\nown\tO\naircraft\tO\nafter\tO\na\tO\nyear\tO\nin\tO\nthe\tO\ncaptivity\tO\nof\tO\nTaleban\tO\nmilitia\tO\nin\tO\nKandahar\tO\nin\tO\nsouthern\tO\nAfghanistan\tO\n.\tO\n\nThe\tO\nthree\tO\nIslamic\tO\nTaleban\tO\nguards\tO\nwere\tO\noverpowered\tO\nby\tO\nseven\tO\nRussian\tO\naircrew\tO\nwho\tO\nescaped\tO\nto\tO\nUAE\tT-2\nstate\tT-2\nSharjah\tB-LOC\nlast\tO\nFriday\tO\non\tO\nboard\tT-1\ntheir\tO\nown\tO\naircraft\tT-0\nafter\tO\na\tO\nyear\tO\nin\tO\nthe\tO\ncaptivity\tO\nof\tO\nTaleban\tO\nmilitia\tO\nin\tO\nKandahar\tO\nin\tO\nsouthern\tO\nAfghanistan\tO\n.\tO\n\nThe\tO\nthree\tO\nIslamic\tO\nTaleban\tO\nguards\tT-1\nwere\tO\noverpowered\tT-2\nby\tO\nseven\tO\nRussian\tO\naircrew\tO\nwho\tO\nescaped\tO\nto\tO\nUAE\tO\nstate\tO\nSharjah\tO\nlast\tO\nFriday\tO\non\tO\nboard\tO\ntheir\tO\nown\tO\naircraft\tO\nafter\tO\na\tO\nyear\tO\nin\tO\nthe\tO\ncaptivity\tO\nof\tO\nTaleban\tB-MISC\nmilitia\tT-0\nin\tO\nKandahar\tO\nin\tO\nsouthern\tO\nAfghanistan\tO\n.\tO\n\nThe\tO\nthree\tO\nIslamic\tO\nTaleban\tO\nguards\tO\nwere\tO\noverpowered\tO\nby\tO\nseven\tO\nRussian\tO\naircrew\tO\nwho\tO\nescaped\tT-0\nto\tO\nUAE\tO\nstate\tO\nSharjah\tT-1\nlast\tO\nFriday\tO\non\tO\nboard\tO\ntheir\tO\nown\tO\naircraft\tO\nafter\tO\na\tO\nyear\tO\nin\tO\nthe\tO\ncaptivity\tO\nof\tO\nTaleban\tT-2\nmilitia\tO\nin\tO\nKandahar\tB-LOC\nin\tO\nsouthern\tO\nAfghanistan\tT-3\n.\tO\n\nThe\tO\nthree\tO\nIslamic\tT-0\nTaleban\tT-0\nguards\tT-0\nwere\tO\noverpowered\tT-2\nby\tO\nseven\tO\nRussian\tT-1\naircrew\tO\nwho\tO\nescaped\tO\nto\tO\nUAE\tT-3\nstate\tO\nSharjah\tT-5\nlast\tO\nFriday\tO\non\tO\nboard\tO\ntheir\tO\nown\tO\naircraft\tO\nafter\tO\na\tO\nyear\tO\nin\tO\nthe\tO\ncaptivity\tO\nof\tO\nTaleban\tT-4\nmilitia\tO\nin\tO\nKandahar\tT-6\nin\tO\nsouthern\tO\nAfghanistan\tB-LOC\n.\tO\n\nThe\tO\nUAE\tB-LOC\nsaid\tT-1\non\tO\nMonday\tO\nit\tO\nwould\tO\nhand\tO\nover\tO\nthe\tO\nthree\tO\nto\tO\nthe\tO\nInternational\tT-0\nRed\tT-0\nCrescent\tT-0\n,\tO\npossibly\tO\nlast\tO\nTuesday\tO\n.\tO\n\nThe\tO\nUAE\tO\nsaid\tT-1\non\tO\nMonday\tO\nit\tO\nwould\tO\nhand\tT-0\nover\tT-0\nthe\tO\nthree\tO\nto\tO\nthe\tO\nInternational\tB-ORG\nRed\tI-ORG\nCrescent\tI-ORG\n,\tO\npossibly\tO\nlast\tO\nTuesday\tO\n.\tO\n\nWhen\tO\nasked\tO\nwhether\tO\nthe\tO\nthree\tO\nguards\tO\nwould\tO\ntravel\tT-0\nback\tT-0\nto\tT-0\nKandahar\tB-LOC\nor\tO\nthe\tO\nAfghan\tO\ncapital\tT-1\nKabul\tO\n,\tO\nthe\tO\nembassy\tO\nofficial\tO\nsaid\tO\n:\tO\n\"\tO\nThat\tO\nhas\tO\nnot\tO\nbeen\tO\ndecided\tO\n,\tO\nbut\tO\npossibly\tO\nKandahar\tO\n.\tO\n\"\tO\n\nWhen\tO\nasked\tT-0\nwhether\tO\nthe\tO\nthree\tO\nguards\tO\nwould\tO\ntravel\tO\nback\tO\nto\tO\nKandahar\tO\nor\tO\nthe\tO\nAfghan\tB-MISC\ncapital\tO\nKabul\tO\n,\tO\nthe\tO\nembassy\tO\nofficial\tT-1\nsaid\tO\n:\tO\n\"\tO\nThat\tO\nhas\tO\nnot\tO\nbeen\tO\ndecided\tO\n,\tO\nbut\tO\npossibly\tO\nKandahar\tO\n.\tO\n\"\tO\n\nWhen\tO\nasked\tO\nwhether\tO\nthe\tO\nthree\tO\nguards\tO\nwould\tO\ntravel\tT-2\nback\tO\nto\tT-3\nKandahar\tO\nor\tO\nthe\tO\nAfghan\tO\ncapital\tT-0\nKabul\tO\n,\tO\nthe\tO\nembassy\tO\nofficial\tO\nsaid\tO\n:\tO\n\"\tO\nThat\tT-1\nhas\tT-1\nnot\tT-1\nbeen\tT-1\ndecided\tT-1\n,\tT-1\nbut\tT-1\npossibly\tT-1\nKandahar\tB-LOC\n.\tO\n\"\tO\n\nKandahar\tB-LOC\nis\tO\nthe\tO\nheadquarters\tO\nof\tO\nthe\tO\nopposition\tO\nTaleban\tT-0\nmilitia\tT-0\n.\tO\n\nKandahar\tO\nis\tO\nthe\tO\nheadquarters\tO\nof\tO\nthe\tO\nopposition\tO\nTaleban\tB-MISC\nmilitia\tT-0\n.\tO\n\nKabul\tB-LOC\nis\tT-1\ncontrolled\tT-1\nby\tT-1\nPresident\tO\nBurhanuddin\tO\nRabbani\tO\n's\tO\ngovernment\tT-0\n,\tO\nwhich\tO\nTaleban\tO\nis\tO\nfighting\tT-2\nto\tT-2\noverthrow\tT-2\n.\tO\n\nKabul\tO\nis\tO\ncontrolled\tO\nby\tO\nPresident\tT-0\nBurhanuddin\tB-PER\nRabbani\tI-PER\n's\tO\ngovernment\tT-1\n,\tO\nwhich\tO\nTaleban\tT-2\nis\tO\nfighting\tO\nto\tO\noverthrow\tO\n.\tO\n\nKabul\tT-0\nis\tO\ncontrolled\tO\nby\tO\nPresident\tO\nBurhanuddin\tO\nRabbani\tO\n's\tO\ngovernment\tO\n,\tO\nwhich\tO\nTaleban\tB-MISC\nis\tT-1\nfighting\tT-1\nto\tT-1\noverthrow\tT-1\n.\tO\n\nThe\tO\nembassy\tO\nofficial\tO\nsaid\tO\nthe\tO\nthree\tO\nmen\tO\n,\tO\nbelieved\tO\nto\tO\nbe\tO\nin\tO\ntheir\tO\n20s\tO\n,\tO\nwere\tO\ncurrently\tT-0\nin\tT-0\nAbu\tB-LOC\nDhabi\tI-LOC\n.\tO\n\nThe\tT-1\nRussians\tB-MISC\n,\tO\nworking\tT-2\nfor\tO\nthe\tO\nAerostan\tO\nfirm\tO\nin\tO\nthe\tO\nRussian\tO\nrepublic\tO\nof\tO\nTatarstan\tO\n,\tO\nwere\tT-0\ntaken\tT-0\nhostage\tO\nafter\tO\na\tO\nTaleban\tO\nMiG-19\tO\nfighter\tO\nforced\tO\ntheir\tO\ncargo\tO\nplane\tO\nto\tO\nland\tO\nin\tO\nAugust\tO\n1995\tO\n.\tO\n\nThe\tO\nRussians\tO\n,\tO\nworking\tT-0\nfor\tT-0\nthe\tT-0\nAerostan\tB-ORG\nfirm\tT-1\nin\tO\nthe\tO\nRussian\tO\nrepublic\tO\nof\tO\nTatarstan\tO\n,\tO\nwere\tO\ntaken\tO\nhostage\tO\nafter\tO\na\tO\nTaleban\tO\nMiG-19\tO\nfighter\tO\nforced\tO\ntheir\tO\ncargo\tO\nplane\tO\nto\tO\nland\tO\nin\tO\nAugust\tO\n1995\tO\n.\tO\n\nThe\tO\nRussians\tT-0\n,\tO\nworking\tO\nfor\tO\nthe\tO\nAerostan\tO\nfirm\tO\nin\tT-5\nthe\tT-5\nRussian\tB-MISC\nrepublic\tO\nof\tO\nTatarstan\tT-1\n,\tO\nwere\tO\ntaken\tO\nhostage\tT-2\nafter\tO\na\tO\nTaleban\tT-3\nMiG-19\tO\nfighter\tO\nforced\tO\ntheir\tO\ncargo\tT-4\nplane\tT-4\nto\tO\nland\tO\nin\tO\nAugust\tO\n1995\tO\n.\tT-3\n\nThe\tO\nRussians\tO\n,\tO\nworking\tT-1\nfor\tO\nthe\tO\nAerostan\tO\nfirm\tO\nin\tO\nthe\tO\nRussian\tT-0\nrepublic\tT-0\nof\tT-0\nTatarstan\tB-LOC\n,\tO\nwere\tO\ntaken\tO\nhostage\tO\nafter\tO\na\tO\nTaleban\tO\nMiG-19\tO\nfighter\tO\nforced\tO\ntheir\tO\ncargo\tO\nplane\tO\nto\tO\nland\tO\nin\tO\nAugust\tO\n1995\tO\n.\tO\n\nThe\tO\nRussians\tO\n,\tO\nworking\tO\nfor\tO\nthe\tO\nAerostan\tT-2\nfirm\tO\nin\tO\nthe\tO\nRussian\tO\nrepublic\tO\nof\tO\nTatarstan\tO\n,\tO\nwere\tO\ntaken\tO\nhostage\tT-0\nafter\tO\na\tO\nTaleban\tB-MISC\nMiG-19\tO\nfighter\tO\nforced\tT-1\ntheir\tO\ncargo\tO\nplane\tO\nto\tO\nland\tO\nin\tO\nAugust\tO\n1995\tO\n.\tO\n\nThe\tO\nRussians\tO\n,\tO\nworking\tO\nfor\tO\nthe\tO\nAerostan\tO\nfirm\tO\nin\tO\nthe\tO\nRussian\tO\nrepublic\tO\nof\tO\nTatarstan\tO\n,\tO\nwere\tO\ntaken\tO\nhostage\tO\nafter\tO\na\tO\nTaleban\tT-0\nMiG-19\tB-MISC\nfighter\tT-1\nforced\tO\ntheir\tO\ncargo\tO\nplane\tO\nto\tO\nland\tO\nin\tO\nAugust\tO\n1995\tO\n.\tO\n\nTaleban\tB-MISC\nsaid\tO\nits\tO\nshipment\tT-3\nof\tO\nammunition\tT-0\nfrom\tO\nAlbania\tT-1\nwas\tO\nevidence\tO\nof\tO\nRussian\tT-2\nmilitary\tO\nsupport\tO\nfor\tO\nRabbani\tO\n's\tO\ngovernment\tO\n.\tO\n\nTaleban\tT-1\nsaid\tO\nits\tO\nshipment\tO\nof\tO\nammunition\tO\nfrom\tT-0\nAlbania\tB-LOC\nwas\tO\nevidence\tO\nof\tO\nRussian\tT-2\nmilitary\tO\nsupport\tO\nfor\tO\nRabbani\tO\n's\tO\ngovernment\tO\n.\tO\n\nTaleban\tO\nsaid\tO\nits\tO\nshipment\tO\nof\tO\nammunition\tO\nfrom\tO\nAlbania\tT-2\nwas\tO\nevidence\tT-1\nof\tO\nRussian\tB-MISC\nmilitary\tT-0\nsupport\tO\nfor\tO\nRabbani\tO\n's\tO\ngovernment\tO\n.\tO\n\nTaleban\tT-1\nsaid\tO\nits\tO\nshipment\tO\nof\tO\nammunition\tO\nfrom\tO\nAlbania\tO\nwas\tO\nevidence\tO\nof\tO\nRussian\tO\nmilitary\tO\nsupport\tO\nfor\tT-0\nRabbani\tB-PER\n's\tO\ngovernment\tT-2\n.\tO\n\nThe\tO\nRussians\tB-MISC\n,\tO\nwho\tT-4\nsaid\tT-4\nthey\tO\noverpowered\tT-2\nthe\tT-3\nguards\tT-3\n--\tO\ntwo\tO\narmed\tO\nwith\tO\nKalashnikov\tO\nautomatic\tO\nrifles\tO\n--\tO\nwhile\tO\ndoing\tO\nregular\tO\nmaintenance\tO\nwork\tO\non\tO\ntheir\tO\nIlyushin\tO\n76\tO\ncargo\tO\nplane\tO\nlast\tO\nFriday\tO\n,\tO\nleft\tO\nthe\tO\nUAE\tT-1\ncapital\tO\nAbu\tO\nDhabi\tO\nfor\tO\nhome\tO\non\tO\nSunday\tO\n.\tO\n\nThe\tO\nRussians\tO\n,\tO\nwho\tO\nsaid\tT-0\nthey\tO\noverpowered\tO\nthe\tO\nguards\tO\n--\tO\ntwo\tO\narmed\tO\nwith\tO\nKalashnikov\tB-MISC\nautomatic\tO\nrifles\tO\n--\tO\nwhile\tO\ndoing\tO\nregular\tO\nmaintenance\tO\nwork\tO\non\tO\ntheir\tO\nIlyushin\tO\n76\tO\ncargo\tO\nplane\tO\nlast\tO\nFriday\tO\n,\tO\nleft\tO\nthe\tO\nUAE\tT-1\ncapital\tO\nAbu\tO\nDhabi\tO\nfor\tO\nhome\tO\non\tO\nSunday\tO\n.\tO\n\nThe\tO\nRussians\tT-1\n,\tO\nwho\tO\nsaid\tO\nthey\tO\noverpowered\tO\nthe\tO\nguards\tT-2\n--\tO\ntwo\tO\narmed\tO\nwith\tO\nKalashnikov\tT-3\nautomatic\tO\nrifles\tO\n--\tO\nwhile\tO\ndoing\tO\nregular\tT-4\nmaintenance\tT-0\nwork\tT-0\non\tT-0\ntheir\tT-0\nIlyushin\tB-MISC\n76\tI-MISC\ncargo\tO\nplane\tO\nlast\tO\nFriday\tO\n,\tO\nleft\tO\nthe\tO\nUAE\tO\ncapital\tO\nAbu\tO\nDhabi\tO\nfor\tO\nhome\tO\non\tO\nSunday\tO\n.\tO\n\nThe\tO\nRussians\tT-1\n,\tO\nwho\tO\nsaid\tO\nthey\tO\noverpowered\tT-0\nthe\tO\nguards\tO\n--\tO\ntwo\tO\narmed\tO\nwith\tO\nKalashnikov\tT-2\nautomatic\tT-2\nrifles\tT-2\n--\tO\nwhile\tO\ndoing\tO\nregular\tO\nmaintenance\tO\nwork\tO\non\tO\ntheir\tO\nIlyushin\tO\n76\tO\ncargo\tO\nplane\tO\nlast\tO\nFriday\tO\n,\tO\nleft\tO\nthe\tT-3\nUAE\tB-LOC\ncapital\tT-4\nAbu\tO\nDhabi\tO\nfor\tO\nhome\tO\non\tO\nSunday\tO\n.\tO\n\nThe\tO\nRussians\tT-0\n,\tO\nwho\tO\nsaid\tT-1\nthey\tO\noverpowered\tO\nthe\tO\nguards\tO\n--\tO\ntwo\tO\narmed\tO\nwith\tO\nKalashnikov\tT-2\nautomatic\tO\nrifles\tO\n--\tO\nwhile\tO\ndoing\tO\nregular\tO\nmaintenance\tO\nwork\tO\non\tO\ntheir\tO\nIlyushin\tT-4\n76\tO\ncargo\tO\nplane\tO\nlast\tO\nFriday\tO\n,\tO\nleft\tO\nthe\tO\nUAE\tT-3\ncapital\tO\nAbu\tB-LOC\nDhabi\tI-LOC\nfor\tO\nhome\tO\non\tO\nSunday\tO\n.\tO\n\nIraq\tB-LOC\n's\tO\nSaddam\tO\nmeets\tO\nRussia\tT-0\n's\tT-0\nZhirinovsky\tO\n.\tO\n\nIraq\tT-1\n's\tO\nSaddam\tB-PER\nmeets\tT-0\nRussia\tO\n's\tO\nZhirinovsky\tT-2\n.\tO\n\nIraq\tT-2\n's\tT-2\nSaddam\tT-2\nmeets\tT-1\nRussia\tB-LOC\n's\tO\nZhirinovsky\tT-0\n.\tT-1\n\nIraq\tT-1\n's\tT-1\nSaddam\tT-3\nmeets\tT-0\nRussia\tT-2\n's\tT-2\nZhirinovsky\tB-PER\n.\tO\n\nIraqi\tB-MISC\nPresident\tT-0\nSaddam\tT-0\nHussein\tT-0\nhas\tO\ntold\tT-1\nvisiting\tO\nRussian\tO\nultra-nationalist\tO\nVladimir\tO\nZhirinovsky\tO\nthat\tO\nBaghdad\tO\nwanted\tT-2\nto\tO\nmaintain\tO\n\"\tO\nfriendship\tT-3\nand\tT-3\ncooperation\tT-3\n\"\tO\nwith\tO\nMoscow\tO\n,\tO\nofficial\tO\nIraqi\tO\nnewspapers\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nIraqi\tO\nPresident\tO\nSaddam\tB-PER\nHussein\tI-PER\nhas\tO\ntold\tO\nvisiting\tT-0\nRussian\tO\nultra-nationalist\tO\nVladimir\tO\nZhirinovsky\tO\nthat\tO\nBaghdad\tO\nwanted\tO\nto\tO\nmaintain\tO\n\"\tO\nfriendship\tO\nand\tO\ncooperation\tO\n\"\tO\nwith\tO\nMoscow\tO\n,\tO\nofficial\tO\nIraqi\tO\nnewspapers\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nIraqi\tO\nPresident\tO\nSaddam\tO\nHussein\tO\nhas\tO\ntold\tO\nvisiting\tT-0\nRussian\tB-MISC\nultra-nationalist\tO\nVladimir\tO\nZhirinovsky\tO\nthat\tO\nBaghdad\tO\nwanted\tO\nto\tO\nmaintain\tO\n\"\tO\nfriendship\tO\nand\tO\ncooperation\tO\n\"\tO\nwith\tO\nMoscow\tO\n,\tO\nofficial\tO\nIraqi\tO\nnewspapers\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nIraqi\tO\nPresident\tO\nSaddam\tO\nHussein\tO\nhas\tO\ntold\tO\nvisiting\tO\nRussian\tO\nultra-nationalist\tT-0\nVladimir\tB-PER\nZhirinovsky\tI-PER\nthat\tO\nBaghdad\tO\nwanted\tO\nto\tO\nmaintain\tO\n\"\tO\nfriendship\tO\nand\tO\ncooperation\tO\n\"\tO\nwith\tO\nMoscow\tO\n,\tO\nofficial\tO\nIraqi\tO\nnewspapers\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nIraqi\tO\nPresident\tO\nSaddam\tO\nHussein\tO\nhas\tO\ntold\tT-1\nvisiting\tO\nRussian\tO\nultra-nationalist\tO\nVladimir\tO\nZhirinovsky\tO\nthat\tO\nBaghdad\tB-LOC\nwanted\tO\nto\tO\nmaintain\tT-2\n\"\tO\nfriendship\tO\nand\tO\ncooperation\tO\n\"\tO\nwith\tO\nMoscow\tT-3\n,\tO\nofficial\tO\nIraqi\tO\nnewspapers\tT-0\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nIraqi\tO\nPresident\tO\nSaddam\tO\nHussein\tO\nhas\tO\ntold\tT-1\nvisiting\tO\nRussian\tO\nultra-nationalist\tO\nVladimir\tO\nZhirinovsky\tO\nthat\tO\nBaghdad\tO\nwanted\tO\nto\tO\nmaintain\tO\n\"\tO\nfriendship\tO\nand\tO\ncooperation\tO\n\"\tO\nwith\tT-0\nMoscow\tB-LOC\n,\tO\nofficial\tO\nIraqi\tT-2\nnewspapers\tT-2\nsaid\tT-3\non\tO\nThursday\tO\n.\tO\n\nIraqi\tO\nPresident\tO\nSaddam\tO\nHussein\tO\nhas\tO\ntold\tO\nvisiting\tO\nRussian\tO\nultra-nationalist\tO\nVladimir\tO\nZhirinovsky\tO\nthat\tO\nBaghdad\tO\nwanted\tO\nto\tO\nmaintain\tO\n\"\tO\nfriendship\tO\nand\tO\ncooperation\tO\n\"\tO\nwith\tT-2\nMoscow\tT-2\n,\tO\nofficial\tT-0\nIraqi\tB-MISC\nnewspapers\tT-1\nsaid\tT-3\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nPresident\tT-0\nSaddam\tB-PER\nHussein\tI-PER\nstressed\tO\nduring\tO\nthe\tO\nmeeting\tO\nIraq\tO\n's\tO\nkeenness\tO\nto\tO\nmaintain\tO\nfriendship\tO\nand\tO\ncooperation\tO\nwith\tO\nRussia\tO\n,\tO\n\"\tO\nthe\tO\npapers\tO\nsaid\tO\n.\tO\n\n\"\tO\nPresident\tT-0\nSaddam\tT-0\nHussein\tT-0\nstressed\tO\nduring\tO\nthe\tO\nmeeting\tT-2\nIraq\tB-LOC\n's\tO\nkeenness\tO\nto\tO\nmaintain\tO\nfriendship\tT-3\nand\tT-3\ncooperation\tT-3\nwith\tT-3\nRussia\tT-3\n,\tO\n\"\tO\nthe\tO\npapers\tO\nsaid\tO\n.\tO\n\n\"\tO\nPresident\tO\nSaddam\tT-0\nHussein\tT-0\nstressed\tT-1\nduring\tO\nthe\tO\nmeeting\tO\nIraq\tO\n's\tO\nkeenness\tO\nto\tO\nmaintain\tO\nfriendship\tO\nand\tO\ncooperation\tO\nwith\tT-2\nRussia\tB-LOC\n,\tO\n\"\tO\nthe\tO\npapers\tO\nsaid\tO\n.\tO\n\nThey\tO\nsaid\tT-3\nZhirinovsky\tB-PER\ntold\tO\nSaddam\tT-2\nbefore\tO\nhe\tO\nleft\tO\nBaghdad\tO\non\tO\nWednesday\tO\nthat\tO\nhis\tO\nLiberal\tO\nDemocratic\tT-0\nparty\tO\nand\tO\nthe\tO\nRussian\tO\nDuma\tO\n(\tO\nparliament\tO\n)\tO\n\"\tO\nare\tO\ncalling\tO\nfor\tO\nan\tO\nimmediate\tO\nlifting\tO\nof\tO\nthe\tO\nembargo\tO\n\"\tO\nimposed\tT-1\non\tO\nIraq\tO\nafter\tO\nits\tO\n1990\tO\ninvasion\tO\nof\tO\nKuwait\tO\n.\tO\n\nThey\tO\nsaid\tO\nZhirinovsky\tT-2\ntold\tT-0\nSaddam\tB-PER\nbefore\tO\nhe\tO\nleft\tO\nBaghdad\tO\non\tO\nWednesday\tO\nthat\tO\nhis\tO\nLiberal\tO\nDemocratic\tO\nparty\tO\nand\tO\nthe\tO\nRussian\tO\nDuma\tO\n(\tO\nparliament\tO\n)\tO\n\"\tO\nare\tO\ncalling\tO\nfor\tO\nan\tO\nimmediate\tO\nlifting\tT-1\nof\tT-1\nthe\tT-1\nembargo\tT-1\n\"\tO\nimposed\tO\non\tO\nIraq\tO\nafter\tO\nits\tO\n1990\tO\ninvasion\tO\nof\tO\nKuwait\tO\n.\tO\n\nThey\tO\nsaid\tO\nZhirinovsky\tO\ntold\tO\nSaddam\tO\nbefore\tO\nhe\tO\nleft\tO\nBaghdad\tB-LOC\non\tO\nWednesday\tO\nthat\tO\nhis\tO\nLiberal\tO\nDemocratic\tO\nparty\tO\nand\tO\nthe\tO\nRussian\tT-0\nDuma\tT-0\n(\tO\nparliament\tO\n)\tO\n\"\tO\nare\tO\ncalling\tO\nfor\tO\nan\tO\nimmediate\tT-3\nlifting\tO\nof\tO\nthe\tO\nembargo\tO\n\"\tO\nimposed\tO\non\tO\nIraq\tT-1\nafter\tO\nits\tO\n1990\tO\ninvasion\tO\nof\tO\nKuwait\tT-2\n.\tO\n\nThey\tT-1\nsaid\tT-1\nZhirinovsky\tO\ntold\tO\nSaddam\tO\nbefore\tO\nhe\tO\nleft\tO\nBaghdad\tO\non\tO\nWednesday\tO\nthat\tO\nhis\tO\nLiberal\tB-ORG\nDemocratic\tI-ORG\nparty\tI-ORG\nand\tO\nthe\tO\nRussian\tO\nDuma\tO\n(\tO\nparliament\tO\n)\tO\n\"\tO\nare\tO\ncalling\tT-0\nfor\tO\nan\tO\nimmediate\tO\nlifting\tO\nof\tO\nthe\tO\nembargo\tO\n\"\tO\nimposed\tO\non\tO\nIraq\tO\nafter\tO\nits\tO\n1990\tO\ninvasion\tT-2\nof\tT-2\nKuwait\tT-2\n.\tO\n\nThey\tO\nsaid\tO\nZhirinovsky\tO\ntold\tO\nSaddam\tO\nbefore\tO\nhe\tO\nleft\tO\nBaghdad\tO\non\tO\nWednesday\tO\nthat\tO\nhis\tO\nLiberal\tO\nDemocratic\tO\nparty\tO\nand\tO\nthe\tO\nRussian\tB-MISC\nDuma\tT-0\n(\tO\nparliament\tT-1\n)\tO\n\"\tO\nare\tO\ncalling\tO\nfor\tO\nan\tO\nimmediate\tO\nlifting\tO\nof\tO\nthe\tO\nembargo\tO\n\"\tO\nimposed\tO\non\tO\nIraq\tO\nafter\tO\nits\tO\n1990\tO\ninvasion\tO\nof\tO\nKuwait\tO\n.\tO\n\nThey\tO\nsaid\tO\nZhirinovsky\tT-0\ntold\tT-4\nSaddam\tT-1\nbefore\tO\nhe\tO\nleft\tO\nBaghdad\tO\non\tO\nWednesday\tO\nthat\tO\nhis\tO\nLiberal\tO\nDemocratic\tO\nparty\tO\nand\tO\nthe\tO\nRussian\tT-2\nDuma\tB-ORG\n(\tO\nparliament\tT-3\n)\tO\n\"\tO\nare\tO\ncalling\tT-5\nfor\tO\nan\tO\nimmediate\tO\nlifting\tO\nof\tO\nthe\tO\nembargo\tO\n\"\tO\nimposed\tO\non\tO\nIraq\tO\nafter\tO\nits\tO\n1990\tO\ninvasion\tT-6\nof\tO\nKuwait\tO\n.\tO\n\nThey\tO\nsaid\tO\nZhirinovsky\tT-1\ntold\tO\nSaddam\tO\nbefore\tO\nhe\tO\nleft\tO\nBaghdad\tT-2\non\tO\nWednesday\tO\nthat\tO\nhis\tO\nLiberal\tO\nDemocratic\tO\nparty\tO\nand\tO\nthe\tO\nRussian\tO\nDuma\tO\n(\tO\nparliament\tO\n)\tO\n\"\tO\nare\tO\ncalling\tO\nfor\tO\nan\tO\nimmediate\tO\nlifting\tO\nof\tO\nthe\tO\nembargo\tO\n\"\tO\nimposed\tO\non\tO\nIraq\tB-LOC\nafter\tO\nits\tO\n1990\tO\ninvasion\tT-0\nof\tO\nKuwait\tO\n.\tO\n\nThey\tO\nsaid\tO\nZhirinovsky\tO\ntold\tO\nSaddam\tO\nbefore\tO\nhe\tO\nleft\tO\nBaghdad\tO\non\tO\nWednesday\tO\nthat\tO\nhis\tO\nLiberal\tO\nDemocratic\tO\nparty\tO\nand\tO\nthe\tO\nRussian\tT-0\nDuma\tO\n(\tO\nparliament\tO\n)\tO\n\"\tO\nare\tO\ncalling\tO\nfor\tO\nan\tO\nimmediate\tO\nlifting\tO\nof\tO\nthe\tO\nembargo\tO\n\"\tO\nimposed\tO\non\tO\nIraq\tO\nafter\tO\nits\tO\n1990\tO\ninvasion\tT-1\nof\tO\nKuwait\tB-LOC\n.\tO\n\nZhirinovsky\tB-PER\nsaid\tT-2\non\tO\nTuesday\tO\nhe\tT-0\nwould\tT-0\npress\tT-0\nthe\tT-0\nRussian\tT-0\ngovernment\tT-0\nto\tO\nhelp\tO\nend\tO\nU.N.\tO\ntrade\tO\nsanctions\tO\non\tO\nIraq\tO\nand\tO\nblamed\tO\nMoscow\tO\nfor\tO\ndelaying\tO\nestablishment\tT-1\nof\tO\ngood\tO\nties\tO\nwith\tO\nBaghdad\tO\n.\tO\n\nZhirinovsky\tO\nsaid\tO\non\tO\nTuesday\tO\nhe\tO\nwould\tO\npress\tO\nthe\tO\nRussian\tB-MISC\ngovernment\tO\nto\tO\nhelp\tO\nend\tO\nU.N.\tO\ntrade\tO\nsanctions\tO\non\tO\nIraq\tO\nand\tO\nblamed\tO\nMoscow\tO\nfor\tO\ndelaying\tT-1\nestablishment\tO\nof\tO\ngood\tO\nties\tO\nwith\tO\nBaghdad\tT-0\n.\tO\n\nZhirinovsky\tO\nsaid\tO\non\tO\nTuesday\tO\nhe\tO\nwould\tO\npress\tO\nthe\tO\nRussian\tO\ngovernment\tO\nto\tO\nhelp\tO\nend\tO\nU.N.\tB-ORG\ntrade\tO\nsanctions\tO\non\tO\nIraq\tO\nand\tO\nblamed\tO\nMoscow\tT-0\nfor\tO\ndelaying\tO\nestablishment\tO\nof\tO\ngood\tO\nties\tO\nwith\tO\nBaghdad\tT-1\n.\tO\n\nZhirinovsky\tT-0\nsaid\tT-1\non\tO\nTuesday\tO\nhe\tO\nwould\tO\npress\tO\nthe\tO\nRussian\tO\ngovernment\tO\nto\tO\nhelp\tO\nend\tO\nU.N.\tO\ntrade\tO\nsanctions\tT-2\non\tO\nIraq\tB-LOC\nand\tO\nblamed\tO\nMoscow\tO\nfor\tO\ndelaying\tO\nestablishment\tO\nof\tO\ngood\tO\nties\tO\nwith\tO\nBaghdad\tO\n.\tO\n\nZhirinovsky\tO\nsaid\tT-0\non\tO\nTuesday\tO\nhe\tO\nwould\tO\npress\tO\nthe\tO\nRussian\tO\ngovernment\tO\nto\tO\nhelp\tO\nend\tO\nU.N.\tO\ntrade\tO\nsanctions\tO\non\tO\nIraq\tO\nand\tO\nblamed\tT-1\nMoscow\tB-LOC\nfor\tO\ndelaying\tO\nestablishment\tT-2\nof\tO\ngood\tO\nties\tO\nwith\tO\nBaghdad\tO\n.\tO\n\nZhirinovsky\tO\nsaid\tT-0\non\tO\nTuesday\tO\nhe\tO\nwould\tO\npress\tT-1\nthe\tO\nRussian\tO\ngovernment\tO\nto\tO\nhelp\tO\nend\tO\nU.N.\tO\ntrade\tT-3\nsanctions\tT-3\non\tO\nIraq\tO\nand\tO\nblamed\tO\nMoscow\tO\nfor\tO\ndelaying\tT-2\nestablishment\tO\nof\tO\ngood\tO\nties\tO\nwith\tO\nBaghdad\tB-LOC\n.\tO\n\n\"\tO\nOur\tO\nstand\tO\nis\tO\nfirm\tO\n,\tO\nnamely\tO\nwe\tO\nare\tO\ncalling\tO\non\tO\n(\tO\nthe\tT-2\nRussian\tB-MISC\n)\tO\ngovernment\tT-0\nto\tO\nend\tO\nthe\tO\neconomic\tT-1\nembargo\tO\non\tO\nIraq\tO\nand\tO\nresume\tO\ntrade\tO\nties\tO\nbetween\tO\nRussia\tO\nand\tO\nIraq\tO\n,\tO\n\"\tO\nhe\tO\ntold\tO\nreporters\tO\n.\tO\n\n\"\tO\nOur\tO\nstand\tO\nis\tO\nfirm\tO\n,\tO\nnamely\tO\nwe\tO\nare\tO\ncalling\tT-1\non\tO\n(\tO\nthe\tO\nRussian\tO\n)\tO\ngovernment\tT-0\nto\tO\nend\tT-2\nthe\tO\neconomic\tO\nembargo\tO\non\tT-4\nIraq\tB-LOC\nand\tO\nresume\tO\ntrade\tO\nties\tT-3\nbetween\tO\nRussia\tO\nand\tO\nIraq\tO\n,\tO\n\"\tO\nhe\tO\ntold\tO\nreporters\tO\n.\tO\n\n\"\tO\nOur\tO\nstand\tO\nis\tO\nfirm\tO\n,\tO\nnamely\tO\nwe\tO\nare\tO\ncalling\tO\non\tO\n(\tO\nthe\tT-0\nRussian\tT-0\n)\tO\ngovernment\tT-3\nto\tO\nend\tO\nthe\tO\neconomic\tT-2\nembargo\tT-2\non\tT-2\nIraq\tO\nand\tO\nresume\tT-1\ntrade\tT-1\nties\tO\nbetween\tO\nRussia\tB-LOC\nand\tO\nIraq\tO\n,\tO\n\"\tO\nhe\tO\ntold\tO\nreporters\tO\n.\tO\n\n\"\tO\nOur\tO\nstand\tO\nis\tO\nfirm\tO\n,\tO\nnamely\tO\nwe\tO\nare\tO\ncalling\tO\non\tO\n(\tO\nthe\tO\nRussian\tO\n)\tO\ngovernment\tO\nto\tO\nend\tO\nthe\tO\neconomic\tO\nembargo\tO\non\tO\nIraq\tO\nand\tO\nresume\tO\ntrade\tT-2\nties\tO\nbetween\tO\nRussia\tT-0\nand\tT-1\nIraq\tB-LOC\n,\tO\n\"\tO\nhe\tO\ntold\tO\nreporters\tO\n.\tO\n\nZhirinovsky\tT-0\nvisited\tO\nIraq\tB-LOC\ntwice\tO\nin\tO\n1995\tO\n.\tO\n\nLast\tO\nOctober\tO\nhe\tO\nwas\tO\ninvited\tO\nto\tO\nattend\tO\nthe\tO\nreferendum\tT-0\nheld\tO\non\tT-3\nIraq\tB-LOC\n's\tO\npresidency\tT-2\n,\tO\nwhich\tO\nextended\tO\nSaddam\tO\n's\tO\nterm\tT-1\nfor\tO\nseven\tO\nmore\tO\nyears\tO\n.\tO\n\nLast\tO\nOctober\tO\nhe\tO\nwas\tO\ninvited\tO\nto\tO\nattend\tT-0\nthe\tO\nreferendum\tO\nheld\tO\non\tO\nIraq\tO\n's\tO\npresidency\tO\n,\tO\nwhich\tO\nextended\tO\nSaddam\tB-PER\n's\tT-1\nterm\tT-1\nfor\tO\nseven\tO\nmore\tO\nyears\tO\n.\tO\n\nPRESS\tT-0\nDIGEST\tT-0\n-\tO\nIraq\tB-LOC\n-\tO\nAug\tO\n22\tO\n.\tO\n\nThese\tO\nare\tO\nsome\tO\nof\tO\nthe\tO\nleading\tO\nstories\tO\nin\tO\nthe\tO\nofficial\tT-0\nIraqi\tB-MISC\npress\tT-1\non\tO\nThursday\tO\n.\tO\n\nReuters\tB-ORG\nhas\tO\nnot\tO\nverified\tT-0\nthese\tO\nstories\tO\nand\tO\ndoes\tO\nnot\tO\nvouch\tO\nfor\tO\ntheir\tO\naccuracy\tO\n.\tO\n\n-\tO\nIraq\tB-LOC\n's\tT-0\nPresident\tT-0\nSaddam\tO\nHussein\tT-1\nmeets\tO\nwith\tO\nchairman\tO\nof\tO\nthe\tO\nRussian\tO\nliberal\tO\ndemocratic\tO\nparty\tO\nVladimir\tO\nZhirinovsky\tO\n.\tT-1\n\n-\tO\nIraq\tO\n's\tO\nPresident\tO\nSaddam\tB-PER\nHussein\tI-PER\nmeets\tT-0\nwith\tO\nchairman\tO\nof\tO\nthe\tO\nRussian\tO\nliberal\tO\ndemocratic\tO\nparty\tO\nVladimir\tO\nZhirinovsky\tO\n.\tO\n\n-\tO\nIraq\tO\n's\tO\nPresident\tO\nSaddam\tO\nHussein\tO\nmeets\tT-0\nwith\tO\nchairman\tT-1\nof\tO\nthe\tO\nRussian\tB-MISC\nliberal\tO\ndemocratic\tO\nparty\tO\nVladimir\tT-2\nZhirinovsky\tT-2\n.\tO\n\n-\tO\nIraq\tO\n's\tO\nPresident\tO\nSaddam\tO\nHussein\tO\nmeets\tT-1\nwith\tO\nchairman\tT-0\nof\tO\nthe\tO\nRussian\tO\nliberal\tO\ndemocratic\tO\nparty\tO\nVladimir\tB-PER\nZhirinovsky\tI-PER\n.\tO\n\n-\tO\nTurkish\tB-MISC\nforeign\tT-0\nminister\tT-0\nsays\tO\nTurkey\tO\nwill\tO\ntake\tO\npart\tO\nin\tO\nthe\tO\nBaghdad\tT-1\ntrade\tO\nfair\tO\nthat\tO\nwill\tO\nbe\tO\nheld\tT-2\nin\tT-2\nNovember\tT-2\n.\tO\n\n-\tO\nTurkish\tO\nforeign\tT-0\nminister\tT-1\nsays\tT-3\nTurkey\tB-LOC\nwill\tO\ntake\tO\npart\tO\nin\tO\nthe\tO\nBaghdad\tT-2\ntrade\tO\nfair\tT-5\nthat\tO\nwill\tO\nbe\tO\nheld\tT-4\nin\tO\nNovember\tO\n.\tO\n\n-\tO\nTurkish\tO\nforeign\tO\nminister\tO\nsays\tO\nTurkey\tO\nwill\tO\ntake\tT-0\npart\tT-0\nin\tO\nthe\tO\nBaghdad\tB-LOC\ntrade\tO\nfair\tO\nthat\tO\nwill\tO\nbe\tO\nheld\tO\nin\tO\nNovember\tT-1\n.\tO\n\n-\tO\nA\tO\nshipload\tO\nof\tO\n12\tO\ntonnes\tO\nof\tO\nrice\tO\narrives\tO\nin\tO\nUmm\tB-LOC\nQasr\tI-LOC\nport\tT-0\nin\tT-0\nthe\tT-0\nGulf\tT-1\n.\tO\n\n-\tO\nA\tO\nshipload\tT-0\nof\tO\n12\tO\ntonnes\tO\nof\tO\nrice\tO\narrives\tO\nin\tO\nUmm\tO\nQasr\tO\nport\tO\nin\tO\nthe\tO\nGulf\tB-LOC\n.\tO\n\nPRESS\tT-0\nDIGEST\tT-0\n-\tO\nLebanon\tB-LOC\n-\tO\nAug\tO\n22\tO\n.\tO\n\nThese\tO\nare\tO\nthe\tO\nleading\tT-0\nstories\tT-3\nin\tT-1\nthe\tT-1\nBeirut\tB-LOC\npress\tT-2\non\tO\nThursday\tO\n.\tO\n\nReuters\tB-ORG\nhas\tO\nnot\tO\nverified\tT-0\nthese\tO\nstories\tO\nand\tO\ndoes\tO\nnot\tO\nvouch\tO\nfor\tO\ntheir\tO\naccuracy\tO\n.\tO\n\n-\tO\nConfrontation\tT-0\nis\tT-0\nescalating\tT-0\nbetween\tO\nHizbollah\tB-ORG\nand\tT-1\nthe\tT-1\ngovernment\tT-1\n.\tO\n\n-\tO\nPrime\tT-0\nMinister\tT-0\nHariri\tB-PER\n:\tO\nIsraeli\tT-1\nthreats\tO\ndo\tO\nno\tO\nserve\tT-2\npeace\tO\n.\tO\n\n-\tO\nPrime\tT-0\nMinister\tT-0\nHariri\tT-0\n:\tO\nIsraeli\tB-MISC\nthreats\tO\ndo\tO\nno\tO\nserve\tO\npeace\tO\n.\tO\n\n-\tO\nParliament\tO\nSpeaker\tT-0\nBerri\tB-PER\n:\tO\nIsrael\tO\nis\tO\npreparing\tO\nfor\tO\nwar\tO\nagainst\tO\nSyria\tO\nand\tO\nLebanon\tO\n.\tO\n\n-\tO\nParliament\tO\nSpeaker\tO\nBerri\tT-0\n:\tO\nIsrael\tB-LOC\nis\tO\npreparing\tO\nfor\tO\nwar\tT-1\nagainst\tO\nSyria\tT-2\nand\tO\nLebanon\tT-3\n.\tO\n\n-\tO\nParliament\tO\nSpeaker\tO\nBerri\tO\n:\tO\nIsrael\tO\nis\tO\npreparing\tT-0\nfor\tO\nwar\tO\nagainst\tO\nSyria\tB-LOC\nand\tO\nLebanon\tO\n.\tO\n\n-\tO\nParliament\tO\nSpeaker\tO\nBerri\tO\n:\tO\nIsrael\tT-0\nis\tO\npreparing\tO\nfor\tO\nwar\tT-2\nagainst\tO\nSyria\tT-1\nand\tO\nLebanon\tB-LOC\n.\tO\n\n-\tO\nParliamentary\tT-0\nbattle\tT-1\nin\tT-2\nBeirut\tB-LOC\n..\tO\n\n-\tO\nContinued\tO\ncriticism\tT-1\nof\tO\nlaw\tT-2\nviolation\tT-2\nincidents\tO\n--\tO\nwhich\tT-0\noccurred\tT-0\nin\tT-0\nthe\tT-0\nMount\tB-LOC\nLebanon\tI-LOC\nelections\tT-3\nlast\tO\nSunday\tO\n.\tO\n\n-\tO\nFinancial\tO\nnegotiations\tT-0\nbetween\tO\nLebanon\tB-LOC\nand\tO\nPakistan\tO\n.\tO\n\n-\tO\nHariri\tB-PER\nto\tO\nstep\tT-1\ninto\tT-1\nthe\tO\nelection\tO\nbattle\tT-2\nwith\tO\nan\tO\nincomplete\tT-0\nlist\tO\n.\tO\n\n-\tO\nMaronite\tB-ORG\nPatriarch\tT-0\nSfeir\tT-1\nexpressed\tO\nsorrow\tO\nover\tO\nthe\tO\nviolations\tO\nin\tO\nSunday\tO\n'\tO\nelections\tO\n.\tO\n\n-\tO\nMaronite\tO\nPatriarch\tO\nSfeir\tB-PER\nexpressed\tT-2\nsorrow\tO\nover\tO\nthe\tO\nviolations\tT-0\nin\tT-0\nSunday\tO\n'\tO\nelections\tT-1\n.\tT-1\n\nCME\tB-ORG\nlive\tO\nand\tO\nfeeder\tO\ncattle\tO\ncalls\tT-1\nrange\tO\nmixed\tO\n.\tO\n\nEarly\tO\ncalls\tT-2\non\tT-2\nCME\tB-ORG\nlive\tT-0\nand\tO\nfeeder\tT-1\ncattle\tT-1\nfutures\tT-1\nranged\tO\nfrom\tO\n0.200\tO\ncent\tO\nhigher\tO\nto\tO\n0.100\tO\nlower\tO\n,\tO\nlivestock\tO\nanalysts\tO\nsaid\tO\n.\tO\n\nMONTGOMERY\tB-LOC\n,\tO\nAla\tT-0\n.\tO\n\nMONTGOMERY\tT-0\n,\tO\nAla\tB-LOC\n.\tO\n\nKinderCare\tB-ORG\nLearning\tI-ORG\nCenters\tI-ORG\nInc\tI-ORG\nsaid\tO\non\tO\nThursday\tO\nthat\tO\na\tO\ndebt\tO\nbuyback\tO\nwould\tO\nmean\tO\nan\tO\nextraordinary\tO\nloss\tT-0\nof\tO\n$\tO\n1.2\tO\nmillion\tO\nin\tO\nits\tO\nfiscal\tO\n1997\tO\nfirst\tO\nquarter\tO\n.\tO\n\nPhilip\tB-PER\nMaslowe\tI-PER\n,\tO\nchief\tT-0\nfinancial\tO\nofficer\tO\nof\tO\nthe\tO\npreschool\tO\nand\tO\nchild\tO\ncare\tO\ncompany\tO\n,\tO\nsaid\tT-1\nthe\tO\nbuyback\tO\n\"\tO\noffered\tO\nan\tO\nopportunity\tO\nto\tO\nreduce\tT-2\nthe\tO\ncompany\tO\n's\tO\nweighted\tO\naverage\tO\ninterest\tO\ncosts\tO\nand\tO\nimprove\tT-3\nfuture\tO\ncash\tO\nflows\tO\nand\tO\nearnings\tO\n.\tO\n\"\tO\n\nRESEARCH\tO\nALERT\tO\n-\tO\nLehman\tB-ORG\nstarts\tT-0\nSNET\tT-0\n.\tO\n\nRESEARCH\tT-2\nALERT\tT-2\n-\tO\nLehman\tT-0\nstarts\tT-1\nSNET\tB-ORG\n.\tO\n\n--\tO\nLehman\tB-ORG\nanalyst\tT-1\nBlake\tT-2\nBath\tT-2\nstarted\tO\nSouthern\tO\nNew\tO\nEngland\tO\nTelecommunciations\tO\nCorp\tO\nwith\tT-0\nan\tT-0\noutperform\tT-0\nrating\tT-0\n,\tO\nhis\tO\noffice\tO\nsaid\tO\n.\tO\n\n--\tO\nLehman\tO\nanalyst\tT-0\nBlake\tB-PER\nBath\tI-PER\nstarted\tT-1\nSouthern\tO\nNew\tO\nEngland\tO\nTelecommunciations\tO\nCorp\tO\nwith\tO\nan\tO\noutperform\tT-2\nrating\tO\n,\tO\nhis\tO\noffice\tO\nsaid\tO\n.\tO\n\n--\tO\nLehman\tO\nanalyst\tO\nBlake\tO\nBath\tO\nstarted\tT-1\nSouthern\tB-ORG\nNew\tI-ORG\nEngland\tI-ORG\nTelecommunciations\tI-ORG\nCorp\tI-ORG\nwith\tO\nan\tO\noutperform\tT-0\nrating\tO\n,\tO\nhis\tO\noffice\tO\nsaid\tO\n.\tO\n\n--\tO\nE.\tT-0\nAuchard\tT-0\n,\tO\nWall\tB-ORG\nStreet\tI-ORG\nbureau\tI-ORG\n,\tO\n212-859-1736\tT-1\n\nGreek\tB-MISC\nsocialists\tT-0\ngive\tT-1\nPM\tT-2\ngreen\tO\nlight\tO\nfor\tO\nelection\tO\n.\tO\n\nThe\tT-0\nGreek\tB-MISC\nsocialist\tO\nparty\tO\n's\tO\nexecutive\tO\nbureau\tO\ngave\tO\nPrime\tT-2\nMinister\tT-2\nCostas\tT-2\nSimitis\tT-2\nits\tT-1\nbacking\tT-1\nif\tO\nhe\tO\nchooses\tO\nto\tO\ncall\tO\nsnap\tO\nelections\tO\n,\tO\nits\tO\ngeneral\tO\nsecretary\tO\nCostas\tT-3\nSkandalidis\tT-3\ntold\tO\nreporters\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nGreek\tT-0\nsocialist\tT-0\nparty\tO\n's\tO\nexecutive\tT-1\nbureau\tT-1\ngave\tO\nPrime\tO\nMinister\tO\nCostas\tB-PER\nSimitis\tI-PER\nits\tO\nbacking\tO\nif\tO\nhe\tO\nchooses\tO\nto\tO\ncall\tO\nsnap\tO\nelections\tO\n,\tO\nits\tO\ngeneral\tO\nsecretary\tO\nCostas\tO\nSkandalidis\tO\ntold\tO\nreporters\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nGreek\tO\nsocialist\tO\nparty\tO\n's\tO\nexecutive\tO\nbureau\tO\ngave\tO\nPrime\tO\nMinister\tO\nCostas\tO\nSimitis\tO\nits\tO\nbacking\tO\nif\tO\nhe\tO\nchooses\tO\nto\tO\ncall\tO\nsnap\tO\nelections\tO\n,\tO\nits\tO\ngeneral\tO\nsecretary\tT-0\nCostas\tB-PER\nSkandalidis\tI-PER\ntold\tO\nreporters\tO\non\tO\nThursday\tO\n.\tO\n\nPrime\tT-0\nMinister\tT-0\nCostas\tB-PER\nSimitis\tI-PER\nwill\tT-1\nmake\tT-1\nan\tO\nofficial\tO\nannouncement\tO\nafter\tO\na\tO\ncabinet\tO\nmeeting\tO\nlater\tO\non\tO\nThursday\tO\n,\tO\nsaid\tO\nSkandalidis\tO\n.\tO\n\nPrime\tO\nMinister\tO\nCostas\tO\nSimitis\tO\nwill\tO\nmake\tO\nan\tO\nofficial\tO\nannouncement\tT-0\nafter\tO\na\tO\ncabinet\tO\nmeeting\tO\nlater\tO\non\tO\nThursday\tO\n,\tO\nsaid\tO\nSkandalidis\tB-PER\n.\tO\n\n--\tO\nDimitris\tB-PER\nKontogiannis\tI-PER\n,\tO\nAthens\tT-0\nNewsroom\tT-0\n+301\tO\n3311812-4\tO\n\n--\tO\nDimitris\tT-0\nKontogiannis\tT-0\n,\tO\nAthens\tB-ORG\nNewsroom\tI-ORG\n+301\tT-1\n3311812-4\tT-1\n\nPRESS\tO\nDIGEST\tT-0\n-\tO\nFrance\tB-LOC\n-\tO\nLe\tO\nMonde\tO\nAug\tO\n22\tO\n.\tO\n\nPRESS\tT-1\nDIGEST\tT-2\n-\tO\nFrance\tT-0\n-\tO\nLe\tB-ORG\nMonde\tI-ORG\nAug\tO\n22\tO\n.\tO\n\n--\tO\nAfricans\tO\nseeking\tT-0\nto\tO\nrenew\tO\nor\tO\nobtain\tO\nwork\tO\nand\tO\nresidence\tO\nrights\tO\nsay\tT-1\nPrime\tT-3\nMinister\tT-3\nAlain\tB-PER\nJuppe\tI-PER\n's\tO\nproposals\tT-4\nare\tO\ninsufficient\tO\nas\tO\nhunger\tO\nstrike\tO\nenters\tT-2\n49th\tO\nday\tO\nin\tO\nParis\tO\nchurch\tO\nand\tO\nWednesday\tO\nrally\tO\nattracts\tO\n8,000\tO\nsympathisers\tO\n.\tO\n\n--\tO\nAfricans\tT-2\nseeking\tO\nto\tO\nrenew\tO\nor\tO\nobtain\tO\nwork\tO\nand\tO\nresidence\tO\nrights\tO\nsay\tO\nPrime\tO\nMinister\tO\nAlain\tO\nJuppe\tO\n's\tO\nproposals\tO\nare\tO\ninsufficient\tO\nas\tO\nhunger\tO\nstrike\tT-0\nenters\tO\n49th\tO\nday\tO\nin\tO\nParis\tB-LOC\nchurch\tT-1\nand\tO\nWednesday\tO\nrally\tO\nattracts\tO\n8,000\tO\nsympathisers\tO\n.\tO\n\n--\tO\nFLNC\tB-ORG\nCorsican\tO\nnationalist\tT-0\nmovement\tT-0\nannounces\tT-1\nend\tO\nof\tO\ntruce\tO\nafter\tO\nlast\tO\nnight\tO\n's\tO\nattacks\tT-2\n.\tO\n\n--\tO\nFLNC\tO\nCorsican\tB-MISC\nnationalist\tT-1\nmovement\tT-1\nannounces\tO\nend\tO\nof\tO\ntruce\tO\nafter\tO\nlast\tO\nnight\tT-0\n's\tT-0\nattacks\tT-0\n.\tO\n\n--\tO\nShutdown\tT-3\nof\tT-5\nBally\tB-ORG\n's\tO\nFrench\tT-0\nfactories\tO\npoints\tO\nup\tO\nshoe\tO\nindustry\tO\ncrisis\tT-4\n,\tO\nwith\tO\nFrench\tT-1\nmanufacturers\tO\nundercut\tO\nby\tO\nlow-wage\tO\ncountry\tO\ncompetition\tT-2\nand\tO\nfailure\tO\nto\tO\nkeep\tO\nabreast\tO\nof\tO\ntrends\tO\n.\tO\n\n--\tO\nShutdown\tT-0\nof\tO\nBally\tO\n's\tO\nFrench\tB-MISC\nfactories\tO\npoints\tO\nup\tO\nshoe\tO\nindustry\tO\ncrisis\tO\n,\tO\nwith\tO\nFrench\tO\nmanufacturers\tO\nundercut\tO\nby\tO\nlow-wage\tO\ncountry\tO\ncompetition\tO\nand\tO\nfailure\tO\nto\tO\nkeep\tO\nabreast\tO\nof\tO\ntrends\tO\n.\tO\n\n--\tO\nShutdown\tO\nof\tO\nBally\tO\n's\tO\nFrench\tO\nfactories\tT-1\npoints\tO\nup\tO\nshoe\tO\nindustry\tO\ncrisis\tT-2\n,\tO\nwith\tO\nFrench\tB-MISC\nmanufacturers\tT-0\nundercut\tT-0\nby\tO\nlow-wage\tO\ncountry\tO\ncompetition\tO\nand\tO\nfailure\tO\nto\tO\nkeep\tO\nabreast\tO\nof\tO\ntrends\tO\n.\tO\n\n--\tO\nSecretary\tT-0\ngeneral\tT-0\nof\tT-0\nthe\tT-0\nSud-PTT\tB-MISC\ntrade\tO\nunion\tO\nat\tO\nFrance\tO\nTelecom\tO\nall\tO\nthe\tO\nelements\tO\nare\tO\nin\tO\nplace\tO\nfor\tO\nsocial\tO\nunrest\tO\nin\tO\nthe\tO\nnext\tO\nfew\tO\nweeks\tO\n.\tO\n\n--\tO\nSecretary\tO\ngeneral\tO\nof\tO\nthe\tO\nSud-PTT\tT-1\ntrade\tO\nunion\tT-0\nat\tO\nFrance\tB-ORG\nTelecom\tI-ORG\nall\tO\nthe\tO\nelements\tO\nare\tO\nin\tO\nplace\tO\nfor\tO\nsocial\tO\nunrest\tO\nin\tO\nthe\tO\nnext\tO\nfew\tO\nweeks\tO\n.\tO\n\n--\tO\nParis\tB-ORG\nNewsroom\tI-ORG\n+33\tT-0\n1\tT-0\n42\tT-0\n21\tT-0\n53\tT-0\n81\tT-0\n\nWell\tT-1\nrepairs\tT-1\nto\tO\nlift\tT-2\nHeidrun\tB-LOC\noil\tO\noutput\tO\n-\tO\nStatoil\tO\n.\tO\n\nWell\tO\nrepairs\tO\nto\tO\nlift\tT-2\nHeidrun\tT-0\noil\tO\noutput\tT-1\n-\tO\nStatoil\tB-ORG\n.\tO\n\nThree\tO\nplugged\tO\nwater\tO\ninjection\tO\nwells\tO\non\tT-0\nthe\tT-0\nHeidrun\tB-LOC\noilfield\tT-1\noff\tO\nmid-Norway\tT-3\nwill\tO\nbe\tO\nreopened\tO\nover\tO\nthe\tO\nnext\tO\nmonth\tO\n,\tO\noperator\tO\nDen\tT-2\nNorske\tT-2\nStats\tT-2\nOljeselskap\tT-2\nAS\tO\n(\tO\nStatoil\tO\n)\tO\nsaid\tO\non\tO\nThursday\tO\n.\tT-3\n\nThree\tO\nplugged\tO\nwater\tO\ninjection\tO\nwells\tO\non\tO\nthe\tO\nHeidrun\tT-0\noilfield\tO\noff\tO\nmid-Norway\tB-MISC\nwill\tO\nbe\tO\nreopened\tT-3\nover\tO\nthe\tO\nnext\tO\nmonth\tO\n,\tO\noperator\tO\nDen\tT-1\nNorske\tT-1\nStats\tT-1\nOljeselskap\tT-2\nAS\tO\n(\tO\nStatoil\tO\n)\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThree\tO\nplugged\tT-5\nwater\tO\ninjection\tO\nwells\tO\non\tO\nthe\tO\nHeidrun\tT-0\noilfield\tT-0\noff\tO\nmid-Norway\tT-1\nwill\tO\nbe\tO\nreopened\tT-2\nover\tO\nthe\tO\nnext\tO\nmonth\tO\n,\tO\noperator\tO\nDen\tB-ORG\nNorske\tI-ORG\nStats\tI-ORG\nOljeselskap\tI-ORG\nAS\tI-ORG\n(\tO\nStatoil\tT-3\n)\tO\nsaid\tT-4\non\tO\nThursday\tO\n.\tT-1\n\nThree\tO\nplugged\tO\nwater\tO\ninjection\tO\nwells\tO\non\tO\nthe\tO\nHeidrun\tO\noilfield\tO\noff\tO\nmid-Norway\tO\nwill\tO\nbe\tO\nreopened\tT-1\nover\tO\nthe\tO\nnext\tO\nmonth\tO\n,\tO\noperator\tO\nDen\tO\nNorske\tO\nStats\tO\nOljeselskap\tO\nAS\tT-0\n(\tO\nStatoil\tB-ORG\n)\tO\nsaid\tT-2\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nplugged\tO\nwells\tO\nhave\tO\naccounted\tO\nfor\tO\na\tO\ndip\tO\nof\tO\n30,000\tO\nbarrels\tO\nper\tO\nday\tO\n(\tO\nbpd\tO\n)\tO\nin\tO\nHeidrun\tB-LOC\noutput\tT-0\nto\tT-0\nroughly\tT-0\n220,000\tT-0\nbpd\tT-0\n,\tO\naccording\tO\nto\tO\nthe\tO\ncompany\tO\n's\tO\nStatus\tO\nWeekly\tO\nnewsletter\tT-1\n.\tO\n\nThe\tO\nplugged\tO\nwells\tO\nhave\tO\naccounted\tT-2\nfor\tO\na\tO\ndip\tO\nof\tO\n30,000\tO\nbarrels\tO\nper\tO\nday\tO\n(\tO\nbpd\tO\n)\tO\nin\tO\nHeidrun\tO\noutput\tT-3\nto\tO\nroughly\tO\n220,000\tO\nbpd\tO\n,\tO\naccording\tO\nto\tO\nthe\tO\ncompany\tT-1\n's\tO\nStatus\tB-ORG\nWeekly\tI-ORG\nnewsletter\tT-0\n.\tO\n\n--\tO\nOslo\tB-LOC\nnewsroom\tT-0\n+47\tO\n22\tO\n42\tO\n50\tO\n41\tO\n\nFinnish\tB-MISC\nApril\tT-1\ntrade\tT-1\nsurplus\tT-1\n3.8\tO\nbillion\tO\nmarkka\tT-0\n-\tO\nNCB\tO\n.\tO\n\nFinnish\tT-1\nApril\tO\ntrade\tT-2\nsurplus\tT-2\n3.8\tT-0\nbillion\tT-0\nmarkka\tT-0\n-\tO\nNCB\tB-ORG\n.\tO\n\nFinland\tB-LOC\n's\tO\ntrade\tT-2\nsurplus\tT-2\nrose\tO\nto\tO\n3.83\tO\nbillion\tO\nmarkka\tO\nin\tO\nApril\tO\nfrom\tO\n3.43\tO\nbillion\tO\nin\tO\nMarch\tO\n,\tO\nthe\tO\nNational\tT-0\nCustoms\tT-0\nBoard\tT-0\n(\tO\nNCB\tO\n)\tO\nsaid\tT-1\nin\tO\na\tO\nstatement\tO\non\tO\nThursday\tO\n.\tO\n\nFinland\tO\n's\tO\ntrade\tT-0\nsurplus\tT-1\nrose\tO\nto\tO\n3.83\tO\nbillion\tO\nmarkka\tO\nin\tO\nApril\tO\nfrom\tO\n3.43\tO\nbillion\tO\nin\tO\nMarch\tO\n,\tO\nthe\tO\nNational\tB-ORG\nCustoms\tI-ORG\nBoard\tI-ORG\n(\tO\nNCB\tO\n)\tO\nsaid\tO\nin\tO\na\tO\nstatement\tT-2\non\tO\nThursday\tO\n.\tO\n\nFinland\tO\n's\tO\ntrade\tT-1\nsurplus\tO\nrose\tO\nto\tO\n3.83\tO\nbillion\tO\nmarkka\tO\nin\tO\nApril\tO\nfrom\tO\n3.43\tO\nbillion\tO\nin\tO\nMarch\tO\n,\tO\nthe\tO\nNational\tT-0\nCustoms\tT-0\nBoard\tO\n(\tO\nNCB\tB-ORG\n)\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nvalue\tO\nof\tO\nexports\tO\nfell\tO\none\tO\npercent\tO\nyear-on-year\tO\nin\tO\nApril\tO\nand\tO\nthe\tO\nvalue\tO\nof\tO\nimports\tO\nfell\tO\ntwo\tO\npercent\tT-0\n,\tO\nNCB\tB-ORG\nsaid\tT-1\n.\tO\n\nThe\tT-1\nBank\tB-ORG\nof\tI-ORG\nFinland\tI-ORG\nearlier\tO\nestimated\tO\nthe\tO\nApril\tO\ntrade\tT-0\nsurplus\tO\nat\tO\n3.2\tO\nbillion\tO\nmarkka\tO\nwith\tO\nexports\tO\nprojected\tO\nat\tO\n14.5\tO\nbillion\tO\nand\tO\nimports\tO\nat\tO\n11.3\tO\nbillion\tO\n.\tO\n\nThe\tO\nNCB\tB-ORG\n's\tO\nofficial\tT-2\nmonthly\tO\ntrade\tO\nstatistics\tO\nare\tO\nlagging\tO\nbehind\tO\ndue\tO\nto\tO\nchanges\tO\nin\tO\ncustoms\tO\nprocedures\tO\nwhen\tO\nFinland\tO\njoined\tT-1\nthe\tO\nEuropean\tT-0\nUnion\tT-0\nat\tO\nthe\tO\nstart\tO\nof\tO\n1995\tO\n.\tO\n\nThe\tO\nNCB\tT-2\n's\tT-2\nofficial\tT-2\nmonthly\tO\ntrade\tO\nstatistics\tO\nare\tO\nlagging\tO\nbehind\tO\ndue\tO\nto\tO\nchanges\tO\nin\tO\ncustoms\tO\nprocedures\tO\nwhen\tO\nFinland\tB-LOC\njoined\tT-1\nthe\tO\nEuropean\tO\nUnion\tT-0\nat\tO\nthe\tO\nstart\tO\nof\tO\n1995\tO\n.\tO\n\nThe\tO\nNCB\tO\n's\tO\nofficial\tO\nmonthly\tT-1\ntrade\tO\nstatistics\tO\nare\tO\nlagging\tO\nbehind\tO\ndue\tO\nto\tO\nchanges\tO\nin\tO\ncustoms\tT-0\nprocedures\tO\nwhen\tO\nFinland\tO\njoined\tO\nthe\tO\nEuropean\tB-ORG\nUnion\tI-ORG\nat\tO\nthe\tO\nstart\tT-2\nof\tO\n1995\tO\n.\tO\n\n--\tO\nHelsinki\tB-ORG\nNewsroom\tI-ORG\n+358\tT-0\n-\tT-0\n0\tT-0\n-\tT-0\n680\tT-0\n50\tT-0\n245\tT-0\n\nDutch\tB-MISC\nstate\tO\nraises\tO\ntap\tO\nsale\tT-1\nprice\tT-0\nto\tO\n99.95\tO\n.\tO\n\nThe\tO\nFinance\tB-ORG\nMinistry\tI-ORG\nraised\tT-1\nthe\tT-0\nprice\tT-0\nfor\tO\ntap\tO\nsales\tO\nof\tO\nthe\tO\nDutch\tT-2\ngovernment\tT-2\n's\tO\nnew\tO\n5.75\tO\npercent\tO\nbond\tT-3\ndue\tO\nSeptember\tO\n2002\tO\nto\tO\n99.95\tO\nfrom\tO\n99.90\tO\n.\tO\n\nThe\tO\nFinance\tT-3\nMinistry\tT-3\nraised\tT-2\nthe\tO\nprice\tO\nfor\tO\ntap\tO\nsales\tO\nof\tO\nthe\tT-0\nDutch\tB-MISC\ngovernment\tT-1\n's\tT-1\nnew\tO\n5.75\tO\npercent\tO\nbond\tO\ndue\tO\nSeptember\tO\n2002\tO\nto\tO\n99.95\tO\nfrom\tO\n99.90\tO\n.\tO\n\nTap\tO\nsales\tO\nbegan\tO\non\tO\nMonday\tT-2\nand\tO\nare\tO\nbeing\tO\nheld\tT-1\ndaily\tO\nfrom\tO\n07.00\tO\nGMT\tB-MISC\nto\tO\n15.00\tO\nGMT\tT-0\nuntil\tO\nfurther\tO\nnotice\tO\n.\tO\n\nTap\tT-1\nsales\tT-1\nbegan\tO\non\tO\nMonday\tO\nand\tO\nare\tO\nbeing\tO\nheld\tT-2\ndaily\tT-2\nfrom\tO\n07.00\tO\nGMT\tO\nto\tO\n15.00\tO\nGMT\tB-MISC\nuntil\tT-0\nfurther\tT-0\nnotice\tT-3\n.\tO\n\n--\tO\nAmsterdam\tB-LOC\nnewsroom\tT-0\n+31\tT-1\n20\tT-1\n504\tT-1\n5000\tT-1\n\nGerman\tB-MISC\nfarm\tT-0\nministry\tT-1\ntells\tT-2\nconsumers\tT-2\nto\tT-2\navoid\tT-2\nBritish\tO\nmutton\tO\n.\tO\n\nGerman\tT-1\nfarm\tT-1\nministry\tT-1\ntells\tO\nconsumers\tT-0\nto\tO\navoid\tO\nBritish\tB-MISC\nmutton\tO\n.\tO\n\nGermany\tB-LOC\n's\tO\nAgriculture\tT-2\nMinistry\tT-2\nsuggested\tO\non\tO\nWednesday\tO\nthat\tO\nconsumers\tO\navoid\tO\neating\tT-3\nmeat\tT-3\nfrom\tO\nBritish\tT-0\nsheep\tT-0\nuntil\tO\nscientists\tT-1\ndetermine\tO\nwhether\tO\nmad\tO\ncow\tO\ndisease\tO\ncan\tO\nbe\tO\ntransmitted\tO\nto\tO\nthe\tO\nanimals\tO\n.\tO\n\nGermany\tT-2\n's\tO\nAgriculture\tB-ORG\nMinistry\tI-ORG\nsuggested\tT-0\non\tO\nWednesday\tO\nthat\tO\nconsumers\tT-1\navoid\tO\neating\tO\nmeat\tO\nfrom\tO\nBritish\tO\nsheep\tO\nuntil\tO\nscientists\tO\ndetermine\tO\nwhether\tO\nmad\tO\ncow\tO\ndisease\tO\ncan\tO\nbe\tO\ntransmitted\tO\nto\tO\nthe\tO\nanimals\tO\n.\tO\n\nGermany\tO\n's\tO\nAgriculture\tT-0\nMinistry\tT-1\nsuggested\tT-2\non\tO\nWednesday\tO\nthat\tO\nconsumers\tO\navoid\tT-3\neating\tT-3\nmeat\tT-4\nfrom\tO\nBritish\tB-MISC\nsheep\tT-5\nuntil\tO\nscientists\tO\ndetermine\tO\nwhether\tO\nmad\tO\ncow\tO\ndisease\tO\ncan\tO\nbe\tO\ntransmitted\tO\nto\tO\nthe\tO\nanimals\tO\n.\tO\n\n\"\tO\nUntil\tO\nthis\tO\nis\tO\ncleared\tT-1\nup\tO\nby\tO\nthe\tO\nEuropean\tB-ORG\nUnion\tI-ORG\n's\tO\nscientific\tT-0\npanels\tT-0\n--\tO\nand\tO\nwe\tO\nhave\tO\nasked\tO\nthis\tO\nto\tO\nbe\tO\ndone\tO\nas\tO\nquickly\tO\nas\tO\npossible\tO\n--\tO\n(\tO\nconsumers\tO\n)\tO\nshould\tT-4\nif\tO\nat\tO\nall\tO\npossible\tO\ngive\tO\npreference\tT-2\nto\tO\nsheepmeat\tO\nfrom\tO\nother\tO\ncountries\tO\n,\tO\n\"\tO\nministry\tO\nofficial\tT-3\nWerner\tO\nZwingmann\tO\ntold\tO\nZDF\tO\ntelevision\tO\n.\tO\n\n\"\tO\nUntil\tO\nthis\tO\nis\tO\ncleared\tO\nup\tO\nby\tO\nthe\tO\nEuropean\tO\nUnion\tO\n's\tO\nscientific\tO\npanels\tO\n--\tO\nand\tO\nwe\tO\nhave\tO\nasked\tO\nthis\tO\nto\tO\nbe\tO\ndone\tO\nas\tO\nquickly\tO\nas\tO\npossible\tO\n--\tO\n(\tO\nconsumers\tO\n)\tO\nshould\tO\nif\tO\nat\tO\nall\tO\npossible\tO\ngive\tO\npreference\tO\nto\tO\nsheepmeat\tO\nfrom\tO\nother\tO\ncountries\tO\n,\tO\n\"\tO\nministry\tT-0\nofficial\tT-0\nWerner\tB-PER\nZwingmann\tI-PER\ntold\tT-1\nZDF\tT-2\ntelevision\tT-2\n.\tO\n\n\"\tO\nUntil\tO\nthis\tO\nis\tO\ncleared\tO\nup\tO\nby\tO\nthe\tO\nEuropean\tO\nUnion\tT-0\n's\tO\nscientific\tO\npanels\tO\n--\tO\nand\tO\nwe\tO\nhave\tO\nasked\tO\nthis\tO\nto\tO\nbe\tO\ndone\tO\nas\tO\nquickly\tO\nas\tO\npossible\tO\n--\tO\n(\tO\nconsumers\tO\n)\tO\nshould\tO\nif\tO\nat\tO\nall\tO\npossible\tO\ngive\tO\npreference\tO\nto\tO\nsheepmeat\tO\nfrom\tO\nother\tO\ncountries\tO\n,\tO\n\"\tO\nministry\tT-1\nofficial\tT-1\nWerner\tT-1\nZwingmann\tT-1\ntold\tO\nZDF\tB-ORG\ntelevision\tT-2\n.\tO\n\nBonn\tB-LOC\nhas\tO\nled\tO\nefforts\tO\nto\tO\nensure\tT-2\nconsumer\tO\nprotection\tO\ntops\tO\nthe\tO\nlist\tO\nof\tO\npriorities\tO\nin\tO\ndealing\tO\nwith\tO\nthe\tO\nmad\tO\ncow\tO\ncrisis\tO\n,\tO\nwhich\tO\nerupted\tT-0\nin\tT-0\nMarch\tT-0\nwhen\tO\nBritain\tO\nacknowledged\tO\nhumans\tO\ncould\tO\ncontract\tO\na\tO\nsimilar\tO\nillness\tO\nby\tO\neating\tT-1\ncontaminated\tT-1\nbeef\tT-1\n.\tO\n\nBonn\tO\nhas\tO\nled\tO\nefforts\tO\nto\tO\nensure\tO\nconsumer\tT-0\nprotection\tO\ntops\tO\nthe\tO\nlist\tO\nof\tO\npriorities\tO\nin\tO\ndealing\tO\nwith\tO\nthe\tO\nmad\tT-1\ncow\tT-1\ncrisis\tT-1\n,\tO\nwhich\tO\nerupted\tO\nin\tO\nMarch\tO\nwhen\tO\nBritain\tB-LOC\nacknowledged\tO\nhumans\tO\ncould\tO\ncontract\tO\na\tO\nsimilar\tO\nillness\tO\nby\tO\neating\tT-2\ncontaminated\tT-3\nbeef\tT-3\n.\tT-3\n\nThe\tO\nEuropean\tB-ORG\nCommission\tI-ORG\nagreed\tT-0\nthis\tO\nmonth\tO\nto\tO\nrethink\tO\na\tO\nproposal\tT-1\nto\tO\nban\tT-2\nthe\tO\nuse\tO\nof\tO\nsuspect\tT-3\nsheep\tO\ntissue\tO\nafter\tO\nsome\tO\nEU\tT-4\nveterinary\tT-4\nexperts\tT-4\nquestioned\tO\nwhether\tO\nit\tO\nwas\tO\njustified\tO\n.\tO\n\nThe\tO\nEuropean\tT-2\nCommission\tT-2\nagreed\tO\nthis\tO\nmonth\tO\nto\tO\nrethink\tO\na\tO\nproposal\tT-1\nto\tO\nban\tO\nthe\tO\nuse\tO\nof\tO\nsuspect\tO\nsheep\tO\ntissue\tO\nafter\tO\nsome\tT-0\nEU\tB-ORG\nveterinary\tT-3\nexperts\tO\nquestioned\tO\nwhether\tO\nit\tO\nwas\tO\njustified\tO\n.\tO\n\nEU\tB-ORG\nFarm\tO\nCommissioner\tT-1\nFranz\tO\nFischler\tO\nhad\tO\nproposed\tT-0\nbanning\tT-0\nsheep\tO\nbrains\tO\n,\tO\nspleens\tO\nand\tO\nspinal\tO\ncords\tO\nfrom\tO\nthe\tO\nhuman\tO\nand\tO\nanimal\tO\nfood\tO\nchains\tO\nafter\tO\nreports\tO\nfrom\tO\nBritain\tO\nand\tO\nFrance\tO\nthat\tO\nunder\tO\nlaboratory\tO\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tO\n(\tO\nBSE\tO\n)\tO\n--\tO\nmad\tO\ncow\tO\ndisease\tO\n.\tO\n\nEU\tO\nFarm\tO\nCommissioner\tT-2\nFranz\tB-PER\nFischler\tI-PER\nhad\tT-3\nproposed\tT-3\nbanning\tO\nsheep\tO\nbrains\tO\n,\tO\nspleens\tO\nand\tO\nspinal\tO\ncords\tO\nfrom\tO\nthe\tO\nhuman\tO\nand\tO\nanimal\tT-0\nfood\tT-0\nchains\tO\nafter\tO\nreports\tO\nfrom\tO\nBritain\tO\nand\tO\nFrance\tO\nthat\tO\nunder\tO\nlaboratory\tT-1\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tO\n(\tO\nBSE\tO\n)\tO\n--\tO\nmad\tO\ncow\tO\ndisease\tO\n.\tO\n\nEU\tO\nFarm\tT-1\nCommissioner\tT-1\nFranz\tT-3\nFischler\tT-3\nhad\tO\nproposed\tO\nbanning\tO\nsheep\tO\nbrains\tO\n,\tO\nspleens\tO\nand\tO\nspinal\tO\ncords\tO\nfrom\tO\nthe\tO\nhuman\tO\nand\tO\nanimal\tO\nfood\tO\nchains\tO\nafter\tO\nreports\tO\nfrom\tT-0\nBritain\tB-LOC\nand\tO\nFrance\tT-2\nthat\tO\nunder\tO\nlaboratory\tO\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tO\n(\tO\nBSE\tO\n)\tO\n--\tO\nmad\tO\ncow\tO\ndisease\tO\n.\tO\n\nEU\tO\nFarm\tO\nCommissioner\tO\nFranz\tO\nFischler\tO\nhad\tO\nproposed\tT-0\nbanning\tO\nsheep\tO\nbrains\tO\n,\tO\nspleens\tO\nand\tO\nspinal\tO\ncords\tO\nfrom\tO\nthe\tO\nhuman\tO\nand\tO\nanimal\tO\nfood\tO\nchains\tO\nafter\tO\nreports\tO\nfrom\tO\nBritain\tO\nand\tO\nFrance\tB-LOC\nthat\tO\nunder\tO\nlaboratory\tO\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tO\nEncephalopathy\tO\n(\tO\nBSE\tO\n)\tO\n--\tO\nmad\tO\ncow\tO\ndisease\tT-1\n.\tO\n\nEU\tO\nFarm\tO\nCommissioner\tO\nFranz\tO\nFischler\tO\nhad\tO\nproposed\tO\nbanning\tO\nsheep\tO\nbrains\tO\n,\tO\nspleens\tO\nand\tO\nspinal\tO\ncords\tO\nfrom\tO\nthe\tO\nhuman\tO\nand\tO\nanimal\tO\nfood\tO\nchains\tO\nafter\tO\nreports\tO\nfrom\tO\nBritain\tO\nand\tO\nFrance\tO\nthat\tO\nunder\tO\nlaboratory\tO\nconditions\tO\nsheep\tO\ncould\tO\ncontract\tO\nBovine\tO\nSpongiform\tT-0\nEncephalopathy\tO\n(\tO\nBSE\tB-MISC\n)\tO\n--\tO\nmad\tT-1\ncow\tO\ndisease\tO\n.\tO\n\nBut\tO\nsome\tO\nmembers\tO\nof\tO\nthe\tO\nEU\tB-ORG\n's\tO\nstanding\tO\nveterinary\tT-1\ncommittee\tO\nquestioned\tT-0\nwhether\tO\nthe\tO\naction\tO\nwas\tO\nnecessary\tT-2\ngiven\tO\nthe\tO\nslight\tO\nrisk\tO\nto\tO\nhuman\tO\nhealth\tO\n.\tO\n\nThe\tO\nquestion\tO\nis\tO\nbeing\tO\nstudied\tT-2\nseparately\tO\nby\tO\ntwo\tO\nEU\tB-ORG\nscientific\tT-1\ncommittees\tT-0\n.\tO\n\nSheep\tO\nhave\tO\nlong\tO\nbeen\tO\nknown\tT-0\nto\tO\ncontract\tO\nscrapie\tO\n,\tO\na\tO\nsimilar\tO\nbrain-wasting\tT-2\ndisease\tT-2\nto\tO\nBSE\tB-MISC\nwhich\tT-3\nis\tO\nbelieved\tO\nto\tO\nhave\tO\nbeen\tO\ntransferred\tT-1\nto\tO\ncattle\tO\nthrough\tO\nfeed\tO\ncontaining\tO\nanimal\tO\nwaste\tO\n.\tO\n\nZDF\tB-ORG\nsaid\tO\nGermany\tO\nimported\tT-0\n47,600\tO\nsheep\tO\nfrom\tO\nBritain\tO\nlast\tO\nyear\tO\n,\tO\nnearly\tO\nhalf\tO\nof\tO\ntotal\tO\nimports\tO\n.\tO\n\nZDF\tO\nsaid\tT-0\nGermany\tB-LOC\nimported\tT-3\n47,600\tO\nsheep\tT-1\nfrom\tO\nBritain\tT-4\nlast\tO\nyear\tO\n,\tO\nnearly\tO\nhalf\tO\nof\tO\ntotal\tO\nimports\tT-2\n.\tO\n\nZDF\tO\nsaid\tT-1\nGermany\tT-3\nimported\tO\n47,600\tO\nsheep\tO\nfrom\tT-0\nBritain\tB-LOC\nlast\tO\nyear\tO\n,\tO\nnearly\tO\nhalf\tO\nof\tO\ntotal\tO\nimports\tT-2\n.\tO\n\nIt\tO\nbrought\tO\nin\tO\n4,275\tO\ntonnes\tT-0\nof\tT-0\nBritish\tB-MISC\nmutton\tT-1\n,\tO\nsome\tO\n10\tO\npercent\tO\nof\tO\noverall\tO\nimports\tO\n.\tO\n\nAfter\tO\nthe\tO\nBritish\tB-MISC\ngovernment\tT-0\nadmitted\tT-1\na\tO\npossible\tO\nlink\tO\nbetween\tO\nmad\tT-2\ncow\tT-2\ndisease\tT-2\nand\tO\nits\tO\nfatal\tO\nhuman\tO\nequivalent\tO\n,\tO\nthe\tO\nEU\tO\nimposed\tO\na\tO\nworldwide\tT-3\nban\tT-3\non\tO\nBritish\tO\nbeef\tO\nexports\tO\n.\tO\n\nAfter\tO\nthe\tO\nBritish\tO\ngovernment\tO\nadmitted\tT-0\na\tO\npossible\tO\nlink\tO\nbetween\tO\nmad\tO\ncow\tO\ndisease\tO\nand\tO\nits\tO\nfatal\tO\nhuman\tO\nequivalent\tO\n,\tO\nthe\tO\nEU\tB-ORG\nimposed\tT-1\na\tO\nworldwide\tO\nban\tO\non\tO\nBritish\tO\nbeef\tO\nexports\tO\n.\tO\n\nEU\tB-ORG\nleaders\tT-0\nagreed\tO\nat\tO\na\tO\nsummit\tO\nin\tO\nJune\tO\nto\tO\na\tO\nprogressive\tT-1\nlifting\tT-1\nof\tO\nthe\tO\nban\tO\nas\tO\nBritain\tT-2\ntakes\tO\nparallel\tO\nmeasures\tO\nto\tO\neradicate\tO\nthe\tO\ndisease\tO\n.\tO\n\nEU\tO\nleaders\tT-3\nagreed\tT-0\nat\tO\na\tO\nsummit\tO\nin\tO\nJune\tO\nto\tO\na\tO\nprogressive\tO\nlifting\tO\nof\tO\nthe\tO\nban\tT-1\nas\tO\nBritain\tB-LOC\ntakes\tO\nparallel\tT-4\nmeasures\tO\nto\tO\neradicate\tO\nthe\tO\ndisease\tT-2\n.\tO\n\nGOLF\tT-0\n-\tO\nSCORES\tO\nAT\tO\nWORLD\tB-MISC\nSERIES\tI-MISC\nOF\tI-MISC\nGOLF\tI-MISC\n.\tO\n\nAKRON\tT-0\n,\tO\nOhio\tB-LOC\n1996-08-22\tO\n\nmillion\tT-0\nNEC\tB-MISC\nWorld\tI-MISC\nSeries\tI-MISC\nof\tI-MISC\nGolf\tI-MISC\nafter\tO\nthe\tO\nfirst\tT-1\nround\tT-1\n\nThursday\tO\nat\tO\nthe\tO\n7,149\tO\nyard\tO\n,\tO\npar\tT-0\n70\tT-0\nFirestone\tB-LOC\nC.C\tI-LOC\ncourse\tT-1\n\n(\tO\nplayers\tT-0\nU.S.\tB-LOC\nunless\tO\nstated\tO\n)\tO\n:\tO\n\n66\tO\nPaul\tB-PER\nGoydos\tI-PER\n,\tO\nBilly\tO\nMayfair\tO\n,\tO\nHidemichi\tT-0\nTanaka\tT-0\n(\tO\nJapan\tO\n)\tO\n\n66\tO\nPaul\tT-2\nGoydos\tT-2\n,\tO\nBilly\tB-PER\nMayfair\tI-PER\n,\tO\nHidemichi\tT-1\nTanaka\tT-1\n(\tO\nJapan\tO\n)\tO\n\n66\tO\nPaul\tO\nGoydos\tT-0\n,\tO\nBilly\tO\nMayfair\tO\n,\tO\nHidemichi\tO\nTanaka\tO\n(\tO\nJapan\tB-LOC\n)\tO\n\n68\tT-0\nSteve\tB-PER\nStricker\tI-PER\n\n69\tO\nJustin\tT-0\nLeonard\tT-0\n,\tO\nMark\tB-PER\nBrooks\tI-PER\n\n70\tO\nTim\tT-0\nHerron\tT-0\n,\tO\nDuffy\tB-PER\nWaldorf\tI-PER\n,\tO\nDavis\tT-1\nLove\tT-1\n,\tO\nAnders\tO\nForsbrand\tO\n\n70\tO\nTim\tT-0\nHerron\tT-0\n,\tO\nDuffy\tT-1\nWaldorf\tT-1\n,\tO\nDavis\tB-PER\nLove\tI-PER\n,\tO\nAnders\tT-2\nForsbrand\tT-2\n\n70\tO\nTim\tT-0\nHerron\tT-0\n,\tO\nDuffy\tO\nWaldorf\tO\n,\tO\nDavis\tO\nLove\tO\n,\tO\nAnders\tB-PER\nForsbrand\tI-PER\n\n(\tO\nSweden\tO\n)\tO\n,\tO\nNick\tB-PER\nFaldo\tI-PER\n(\tO\nBritain\tT-0\n)\tO\n,\tO\nJohn\tO\nCook\tO\n,\tO\nSteve\tO\nJones\tO\n,\tO\nPhil\tO\n\n(\tO\nSweden\tO\n)\tO\n,\tO\nNick\tT-0\nFaldo\tT-0\n(\tO\nBritain\tO\n)\tO\n,\tO\nJohn\tT-1\nCook\tT-1\n,\tO\nSteve\tB-PER\nJones\tI-PER\n,\tO\nPhil\tO\n\nMickelson\tT-0\n,\tO\nGreg\tB-PER\nNorman\tI-PER\n(\tO\nAustralia\tT-1\n)\tO\n\n71\tT-1\nErnie\tB-PER\nEls\tI-PER\n(\tO\nSouth\tT-0\nAfrica\tT-0\n)\tO\n,\tO\nScott\tO\nHoch\tO\n\n71\tT-0\nErnie\tT-0\nEls\tT-0\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\n,\tO\nScott\tO\nHoch\tO\n\n72\tO\nClarence\tB-PER\nRose\tI-PER\n,\tO\nLoren\tO\nRoberts\tO\n,\tO\nFred\tT-0\nFunk\tT-0\n,\tO\nSven\tT-1\nStruver\tT-1\n\n72\tO\nClarence\tT-0\nRose\tT-0\n,\tO\nLoren\tB-PER\nRoberts\tI-PER\n,\tO\nFred\tO\nFunk\tO\n,\tO\nSven\tO\nStruver\tO\n\n72\tT-0\nClarence\tO\nRose\tO\n,\tO\nLoren\tO\nRoberts\tO\n,\tO\nFred\tB-PER\nFunk\tI-PER\n,\tO\nSven\tO\nStruver\tO\n\n72\tO\nClarence\tT-0\nRose\tT-0\n,\tO\nLoren\tT-1\nRoberts\tT-1\n,\tO\nFred\tT-2\nFunk\tT-2\n,\tO\nSven\tB-PER\nStruver\tI-PER\n\n(\tO\nGermany\tB-LOC\n)\tO\n,\tO\nAlexander\tT-1\nCejka\tT-1\n(\tO\nGermany\tT-0\n)\tO\n,\tO\nHal\tO\nSutton\tO\n,\tO\nTom\tO\nLehman\tO\n\n(\tO\nGermany\tT-0\n)\tO\n,\tO\nAlexander\tB-PER\nCejka\tI-PER\n(\tO\nGermany\tT-1\n)\tO\n,\tO\nHal\tT-2\nSutton\tT-2\n,\tO\nTom\tO\nLehman\tO\n\n(\tO\nGermany\tT-0\n)\tO\n,\tO\nAlexander\tT-1\nCejka\tT-1\n(\tO\nGermany\tB-LOC\n)\tO\n,\tO\nHal\tT-2\nSutton\tT-2\n,\tO\nTom\tT-3\nLehman\tT-3\n\n(\tO\nGermany\tO\n)\tO\n,\tO\nAlexander\tT-0\nCejka\tT-0\n(\tO\nGermany\tO\n)\tO\n,\tO\nHal\tB-PER\nSutton\tI-PER\n,\tO\nTom\tT-1\nLehman\tT-1\n\n(\tO\nGermany\tT-1\n)\tO\n,\tO\nAlexander\tT-0\nCejka\tT-0\n(\tO\nGermany\tT-2\n)\tO\n,\tO\nHal\tO\nSutton\tO\n,\tO\nTom\tB-PER\nLehman\tI-PER\n\n73\tO\nD.A.\tB-PER\nWeibring\tI-PER\n,\tO\nBrad\tO\nBryant\tO\n,\tO\nCraig\tO\nParry\tO\n(\tO\nAustralia\tT-0\n)\tO\n,\tO\n\n73\tO\nD.A.\tO\nWeibring\tO\n,\tO\nBrad\tB-PER\nBryant\tI-PER\n,\tO\nCraig\tT-0\nParry\tT-0\n(\tO\nAustralia\tO\n)\tO\n,\tO\n\n73\tO\nD.A.\tT-0\nWeibring\tT-3\n,\tO\nBrad\tT-1\nBryant\tT-1\n,\tO\nCraig\tB-PER\nParry\tI-PER\n(\tO\nAustralia\tT-2\n)\tO\n,\tO\n\n73\tO\nD.A.\tO\nWeibring\tO\n,\tO\nBrad\tO\nBryant\tO\n,\tO\nCraig\tT-0\nParry\tT-1\n(\tO\nAustralia\tB-LOC\n)\tO\n,\tO\n\nStewart\tB-PER\nGinn\tI-PER\n(\tO\nAustralia\tT-1\n)\tO\n,\tO\nCorey\tT-0\nPavin\tT-0\n,\tO\nCraig\tO\nStadler\tO\n,\tO\nMark\tO\n\nStewart\tO\nGinn\tO\n(\tO\nAustralia\tB-LOC\n)\tO\n,\tO\nCorey\tT-0\nPavin\tT-0\n,\tO\nCraig\tT-1\nStadler\tT-1\n,\tO\nMark\tO\n\nStewart\tT-0\nGinn\tT-0\n(\tO\nAustralia\tO\n)\tO\n,\tO\nCorey\tB-PER\nPavin\tI-PER\n,\tO\nCraig\tT-1\nStadler\tT-1\n,\tO\nMark\tT-2\n\nStewart\tT-0\nGinn\tT-0\n(\tO\nAustralia\tO\n)\tO\n,\tO\nCorey\tO\nPavin\tO\n,\tO\nCraig\tB-PER\nStadler\tI-PER\n,\tO\nMark\tO\n\nStewart\tO\nGinn\tO\n(\tO\nAustralia\tO\n)\tO\n,\tO\nCorey\tT-0\nPavin\tT-0\n,\tO\nCraig\tT-1\nStadler\tT-1\n,\tO\nMark\tB-PER\n\nO'Meara\tB-PER\n,\tO\nFred\tO\nCouples\tT-0\n\n74\tO\nPaul\tB-PER\nStankowski\tI-PER\n,\tO\nCostantino\tT-0\nRocca\tO\n(\tO\nItaly\tO\n)\tO\n\n74\tO\nPaul\tT-0\nStankowski\tT-0\n,\tO\nCostantino\tB-PER\nRocca\tI-PER\n(\tO\nItaly\tT-1\n)\tO\n\n74\tO\nPaul\tT-0\nStankowski\tT-0\n,\tO\nCostantino\tT-1\nRocca\tT-1\n(\tO\nItaly\tB-LOC\n)\tO\n\n75\tO\nJim\tB-PER\nFuryk\tI-PER\n,\tO\nSatoshi\tT-0\nHigashi\tT-0\n(\tO\nJapan\tO\n)\tO\n,\tO\nWillie\tT-1\nWood\tT-1\n,\tO\nShigeki\tT-2\n\n75\tO\nJim\tO\nFuryk\tO\n,\tO\nSatoshi\tB-PER\nHigashi\tI-PER\n(\tO\nJapan\tT-0\n)\tO\n,\tO\nWillie\tO\nWood\tO\n,\tO\nShigeki\tO\n\n75\tO\nJim\tT-2\nFuryk\tT-2\n,\tO\nSatoshi\tO\nHigashi\tO\n(\tO\nJapan\tT-0\n)\tO\n,\tO\nWillie\tB-PER\nWood\tI-PER\n,\tO\nShigeki\tT-1\n\n75\tO\nJim\tT-0\nFuryk\tT-0\n,\tO\nSatoshi\tT-1\nHigashi\tT-1\n(\tO\nJapan\tO\n)\tO\n,\tO\nWillie\tT-2\nWood\tT-2\n,\tO\nShigeki\tB-PER\n\nMaruyama\tT-0\n(\tO\nJapan\tB-LOC\n)\tO\n\n76\tT-0\nScott\tB-PER\nMcCarron\tI-PER\n\n77\tO\nWayne\tB-PER\nWestner\tI-PER\n(\tO\nSouth\tT-0\nAfrica\tT-0\n)\tO\n,\tO\nSteve\tT-1\nSchneiter\tT-1\n\n77\tO\nWayne\tT-0\nWestner\tT-0\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\n,\tO\nSteve\tO\nSchneiter\tO\n\n77\tO\nWayne\tO\nWestner\tO\n(\tO\nSouth\tT-0\nAfrica\tT-0\n)\tO\n,\tO\nSteve\tB-PER\nSchneiter\tI-PER\n\n79\tT-0\nTom\tB-PER\nWatson\tI-PER\n\n81\tO\nSeiki\tB-PER\nOkuda\tI-PER\n(\tO\nJapan\tT-0\n)\tO\n\n81\tO\nSeiki\tT-0\nOkuda\tT-0\n(\tO\nJapan\tB-LOC\n)\tO\n\nSOCCER\tT-0\n-\tO\nGLORIA\tB-ORG\nBISTRITA\tI-ORG\nBEAT\tT-1\n2-1\tO\nF.C.\tO\nVALLETTA\tT-2\n.\tO\n\nSOCCER\tT-0\n-\tO\nGLORIA\tO\nBISTRITA\tO\nBEAT\tO\n2-1\tO\nF.C.\tB-ORG\nVALLETTA\tI-ORG\n.\tO\n\nGloria\tB-ORG\nBistrita\tI-ORG\n(\tO\nRomania\tT-3\n)\tO\nbeat\tT-4\n2-1\tT-4\n(\tO\nhalftime\tO\n1-1\tO\n)\tO\nF.C.\tO\nValletta\tO\n(\tO\nMalta\tO\n)\tO\nin\tO\ntheir\tO\nCup\tT-1\nwinners\tT-1\nCup\tT-2\nmatch\tT-2\n,\tO\nsecond\tO\nleg\tO\nof\tO\nthe\tO\npreliminary\tT-0\nround\tO\n,\tO\non\tO\nThursday\tO\n.\tO\n\nGloria\tO\nBistrita\tO\n(\tO\nRomania\tB-LOC\n)\tO\nbeat\tO\n2-1\tO\n(\tO\nhalftime\tO\n1-1\tO\n)\tO\nF.C.\tO\nValletta\tO\n(\tO\nMalta\tT-0\n)\tO\nin\tO\ntheir\tO\nCup\tO\nwinners\tT-1\nCup\tT-1\nmatch\tT-1\n,\tO\nsecond\tO\nleg\tO\nof\tO\nthe\tO\npreliminary\tO\nround\tO\n,\tO\non\tO\nThursday\tO\n.\tO\n\nGloria\tO\nBistrita\tO\n(\tO\nRomania\tO\n)\tO\nbeat\tT-0\n2-1\tO\n(\tO\nhalftime\tO\n1-1\tO\n)\tO\nF.C.\tB-ORG\nValletta\tI-ORG\n(\tO\nMalta\tO\n)\tO\nin\tO\ntheir\tO\nCup\tT-3\nwinners\tT-3\nCup\tO\nmatch\tT-1\n,\tO\nsecond\tO\nleg\tO\nof\tO\nthe\tO\npreliminary\tT-2\nround\tT-2\n,\tO\non\tO\nThursday\tO\n.\tO\n\nGloria\tT-1\nBistrita\tT-1\n(\tO\nRomania\tT-3\n)\tO\nbeat\tT-4\n2-1\tO\n(\tO\nhalftime\tO\n1-1\tO\n)\tO\nF.C.\tT-2\nValletta\tT-2\n(\tO\nMalta\tB-LOC\n)\tO\nin\tO\ntheir\tO\nCup\tT-0\nwinners\tO\nCup\tO\nmatch\tO\n,\tO\nsecond\tO\nleg\tO\nof\tO\nthe\tO\npreliminary\tO\nround\tO\n,\tO\non\tO\nThursday\tO\n.\tO\n\nGloria\tO\nBistrita\tO\n(\tO\nRomania\tO\n)\tO\nbeat\tO\n2-1\tO\n(\tO\nhalftime\tO\n1-1\tO\n)\tO\nF.C.\tO\nValletta\tO\n(\tO\nMalta\tO\n)\tO\nin\tO\ntheir\tT-2\nCup\tB-MISC\nwinners\tI-MISC\nCup\tI-MISC\nmatch\tT-0\n,\tO\nsecond\tT-1\nleg\tT-1\nof\tO\nthe\tO\npreliminary\tO\nround\tO\n,\tO\non\tO\nThursday\tO\n.\tO\n\nGloria\tB-ORG\nBistrita\tI-ORG\n-\tO\nIlie\tT-0\nLazar\tT-0\n(\tO\n32nd\tO\n)\tO\n,\tO\nEugen\tT-1\nVoica\tT-1\n(\tO\n84th\tO\n)\tO\n\nGloria\tO\nBistrita\tO\n-\tO\nIlie\tB-PER\nLazar\tI-PER\n(\tO\n32nd\tO\n)\tO\n,\tO\nEugen\tT-0\nVoica\tT-0\n(\tO\n84th\tO\n)\tO\n\nGloria\tO\nBistrita\tO\n-\tO\nIlie\tO\nLazar\tO\n(\tO\n32nd\tO\n)\tO\n,\tO\nEugen\tB-PER\nVoica\tI-PER\n(\tT-0\n84th\tT-0\n)\tT-0\n\nF.C.\tT-0\nLa\tT-0\nValletta\tT-0\n-\tO\nGilbert\tB-PER\nAgius\tI-PER\n(\tO\n24th\tO\n)\tO\n\nGloria\tB-ORG\nBistrita\tI-ORG\nwon\tO\n4-2\tO\non\tO\naggregate\tT-1\nand\tO\nqualified\tT-2\nfor\tO\nthe\tO\nfirst\tO\nround\tO\nof\tO\nthe\tO\nCup\tT-0\nwinners\tT-0\nCup\tT-0\n.\tO\n\nGloria\tT-3\nBistrita\tT-3\nwon\tT-1\n4-2\tO\non\tO\naggregate\tO\nand\tO\nqualified\tT-2\nfor\tO\nthe\tO\nfirst\tO\nround\tO\nof\tO\nthe\tT-0\nCup\tB-MISC\nwinners\tI-MISC\nCup\tI-MISC\n.\tO\n\nHORSE\tO\nRACING\tO\n-\tO\nPIVOTAL\tB-PER\nENDS\tT-0\n25-YEAR\tO\nWAIT\tO\nFOR\tO\nTRAINER\tT-1\nPRESCOTT\tO\n.\tO\n\nHORSE\tO\nRACING\tO\n-\tO\nPIVOTAL\tT-0\nENDS\tO\n25-YEAR\tO\nWAIT\tO\nFOR\tO\nTRAINER\tO\nPRESCOTT\tB-PER\n.\tO\n\nYORK\tB-LOC\n,\tO\nEngland\tT-0\n1996-08-22\tO\n\nYORK\tT-1\n,\tO\nEngland\tB-LOC\n1996-08-22\tT-0\n\nSir\tT-1\nMark\tB-PER\nPrescott\tI-PER\nlanded\tT-3\nhis\tO\nfirst\tO\ngroup\tO\none\tO\nvictory\tO\nin\tO\n25\tO\nyears\tO\nas\tO\na\tO\ntrainer\tO\nwhen\tO\nhis\tO\ntop\tO\nsprinter\tO\nPivotal\tO\n,\tO\na\tO\n100-30\tO\nchance\tO\n,\tO\nwon\tT-2\nthe\tO\nNunthorpe\tT-0\nStakes\tT-0\non\tO\nThursday\tO\n.\tO\n\nSir\tT-1\nMark\tT-1\nPrescott\tT-1\nlanded\tO\nhis\tO\nfirst\tO\ngroup\tO\none\tO\nvictory\tT-2\nin\tO\n25\tO\nyears\tO\nas\tO\na\tO\ntrainer\tO\nwhen\tO\nhis\tO\ntop\tO\nsprinter\tT-3\nPivotal\tB-PER\n,\tO\na\tO\n100-30\tO\nchance\tO\n,\tO\nwon\tT-4\nthe\tO\nNunthorpe\tO\nStakes\tO\non\tO\nThursday\tO\n.\tO\n\nSir\tT-0\nMark\tT-0\nPrescott\tT-0\nlanded\tO\nhis\tO\nfirst\tO\ngroup\tO\none\tO\nvictory\tO\nin\tO\n25\tO\nyears\tO\nas\tO\na\tO\ntrainer\tO\nwhen\tO\nhis\tO\ntop\tO\nsprinter\tO\nPivotal\tO\n,\tO\na\tO\n100-30\tO\nchance\tO\n,\tO\nwon\tO\nthe\tO\nNunthorpe\tB-MISC\nStakes\tI-MISC\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nthree-year-old\tO\n,\tO\npartnered\tO\nby\tO\nveteran\tT-0\nGeorge\tB-PER\nDuffield\tI-PER\n,\tO\nsnatched\tO\na\tO\nshort\tO\nhead\tO\nverdict\tO\nin\tO\nthe\tO\nlast\tO\nstride\tO\nto\tO\ndeny\tO\nEveningperformance\tO\n(\tO\n16-1\tO\n)\tO\n,\tO\ntrained\tO\nby\tO\nHenry\tO\nCandy\tO\nand\tO\nridden\tO\nby\tO\nChris\tO\nRutter\tO\n.\tO\n\nThe\tO\nthree-year-old\tO\n,\tO\npartnered\tO\nby\tO\nveteran\tO\nGeorge\tO\nDuffield\tO\n,\tO\nsnatched\tO\na\tO\nshort\tO\nhead\tO\nverdict\tO\nin\tO\nthe\tO\nlast\tO\nstride\tO\nto\tT-0\ndeny\tT-0\nEveningperformance\tB-PER\n(\tO\n16-1\tO\n)\tO\n,\tO\ntrained\tT-1\nby\tO\nHenry\tO\nCandy\tO\nand\tO\nridden\tO\nby\tO\nChris\tO\nRutter\tO\n.\tO\n\nThe\tO\nthree-year-old\tO\n,\tO\npartnered\tO\nby\tO\nveteran\tO\nGeorge\tO\nDuffield\tO\n,\tO\nsnatched\tT-2\na\tO\nshort\tO\nhead\tO\nverdict\tO\nin\tO\nthe\tO\nlast\tO\nstride\tO\nto\tO\ndeny\tO\nEveningperformance\tO\n(\tO\n16-1\tO\n)\tO\n,\tO\ntrained\tT-3\nby\tO\nHenry\tB-PER\nCandy\tI-PER\nand\tO\nridden\tT-0\nby\tO\nChris\tT-1\nRutter\tT-1\n.\tO\n\nThe\tO\nthree-year-old\tO\n,\tO\npartnered\tT-0\nby\tO\nveteran\tO\nGeorge\tO\nDuffield\tO\n,\tO\nsnatched\tO\na\tO\nshort\tO\nhead\tO\nverdict\tO\nin\tO\nthe\tO\nlast\tO\nstride\tO\nto\tO\ndeny\tO\nEveningperformance\tO\n(\tO\n16-1\tO\n)\tO\n,\tO\ntrained\tO\nby\tO\nHenry\tO\nCandy\tO\nand\tO\nridden\tO\nby\tO\nChris\tB-PER\nRutter\tI-PER\n.\tO\n\nHever\tB-PER\nGolf\tI-PER\nRose\tI-PER\n(\tO\n11-4\tO\n)\tO\n,\tO\nlast\tO\nyear\tO\n's\tO\nPrix\tO\nde\tO\nl\tO\n'\tO\nAbbaye\tO\nwinner\tT-0\nat\tO\nLongchamp\tO\n,\tO\nfinished\tO\nthird\tO\n,\tO\na\tO\nfurther\tO\none\tO\nand\tO\na\tO\nquarter\tO\nlengths\tO\naway\tO\nwith\tO\nthe\tO\n7-4\tO\nfavourite\tO\nMind\tO\nGames\tO\nin\tO\nfourth\tO\n.\tO\n\nHever\tT-3\nGolf\tT-3\nRose\tT-3\n(\tO\n11-4\tO\n)\tO\n,\tO\nlast\tT-0\nyear\tT-0\n's\tT-0\nPrix\tB-MISC\nde\tI-MISC\nl\tI-MISC\n'\tI-MISC\nAbbaye\tI-MISC\nwinner\tT-1\nat\tO\nLongchamp\tO\n,\tO\nfinished\tO\nthird\tO\n,\tO\na\tO\nfurther\tO\none\tO\nand\tO\na\tO\nquarter\tO\nlengths\tO\naway\tO\nwith\tO\nthe\tO\n7-4\tO\nfavourite\tO\nMind\tO\nGames\tT-2\nin\tO\nfourth\tO\n.\tO\n\nHever\tO\nGolf\tO\nRose\tO\n(\tO\n11-4\tO\n)\tO\n,\tO\nlast\tO\nyear\tO\n's\tO\nPrix\tO\nde\tO\nl\tO\n'\tO\nAbbaye\tO\nwinner\tT-1\nat\tO\nLongchamp\tB-LOC\n,\tO\nfinished\tT-0\nthird\tT-2\n,\tO\na\tO\nfurther\tO\none\tO\nand\tO\na\tO\nquarter\tO\nlengths\tO\naway\tO\nwith\tO\nthe\tO\n7-4\tO\nfavourite\tO\nMind\tO\nGames\tO\nin\tO\nfourth\tO\n.\tO\n\nHever\tO\nGolf\tT-2\nRose\tT-2\n(\tT-2\n11-4\tO\n)\tO\n,\tO\nlast\tO\nyear\tO\n's\tO\nPrix\tO\nde\tO\nl\tO\n'\tO\nAbbaye\tT-3\nwinner\tT-1\nat\tO\nLongchamp\tT-0\n,\tO\nfinished\tO\nthird\tO\n,\tO\na\tO\nfurther\tO\none\tO\nand\tO\na\tO\nquarter\tO\nlengths\tO\naway\tO\nwith\tO\nthe\tO\n7-4\tO\nfavourite\tO\nMind\tB-PER\nGames\tI-PER\nin\tO\nfourth\tO\n.\tO\n\nPivotal\tB-PER\n,\tO\na\tO\nRoyal\tT-1\nAscot\tT-2\nwinner\tT-3\nin\tO\nJune\tO\n,\tO\nmay\tO\nnow\tO\nbe\tO\naimed\tO\nat\tO\nthis\tO\nseason\tO\n's\tO\nAbbaye\tT-0\n,\tO\nEurope\tO\n's\tO\ntop\tO\nsprint\tO\nrace\tO\n.\tO\n\nPivotal\tO\n,\tO\na\tO\nRoyal\tB-PER\nAscot\tI-PER\nwinner\tO\nin\tO\nJune\tO\n,\tO\nmay\tO\nnow\tO\nbe\tO\naimed\tT-0\nat\tO\nthis\tO\nseason\tO\n's\tO\nAbbaye\tO\n,\tO\nEurope\tO\n's\tO\ntop\tO\nsprint\tO\nrace\tO\n.\tO\n\nPivotal\tO\n,\tO\na\tO\nRoyal\tO\nAscot\tO\nwinner\tO\nin\tO\nJune\tO\n,\tO\nmay\tO\nnow\tO\nbe\tO\naimed\tO\nat\tO\nthis\tT-1\nseason\tT-1\n's\tT-1\nAbbaye\tB-MISC\n,\tO\nEurope\tT-0\n's\tO\ntop\tO\nsprint\tO\nrace\tO\n.\tO\n\nPivotal\tT-1\n,\tO\na\tO\nRoyal\tT-2\nAscot\tT-2\nwinner\tO\nin\tT-3\nJune\tO\n,\tO\nmay\tO\nnow\tO\nbe\tO\naimed\tO\nat\tT-4\nthis\tO\nseason\tO\n's\tO\nAbbaye\tT-0\n,\tO\nEurope\tB-LOC\n's\tO\ntop\tO\nsprint\tO\nrace\tO\n.\tO\n\nPrescott\tB-PER\n,\tO\nreluctant\tT-2\nto\tO\ngo\tO\ninto\tO\nthe\tO\nwinner\tO\n's\tO\nenclosure\tT-0\nuntil\tO\nthe\tO\nresult\tO\nof\tO\nthe\tO\nphoto-finish\tO\nwas\tO\nannounced\tO\n,\tO\nsaid\tO\n:\tO\n\"\tO\nTwenty-five\tO\nyears\tO\nand\tO\nI\tO\nhave\tO\nnever\tO\nbeen\tT-1\nthere\tO\nso\tO\nI\tO\nthought\tO\nI\tO\nhad\tO\nbetter\tO\nwait\tO\na\tO\nbit\tO\nlonger\tO\n.\tO\n\"\tO\n\nHe\tO\nadded\tT-0\n:\tO\n\"\tO\nIt\tO\n's\tO\nvery\tO\nsad\tO\nto\tO\nbeat\tT-1\nHenry\tB-PER\nCandy\tI-PER\nbecause\tO\nI\tO\nam\tO\ngodfather\tO\nto\tO\nhis\tO\ndaughter\tO\n.\tO\n\"\tO\n\nLike\tT-1\nPrescott\tB-PER\n,\tO\nJack\tT-0\nBerry\tT-0\n,\tO\ntrainer\tO\nof\tO\nMind\tO\nGames\tO\n,\tO\nhad\tO\ngone\tO\ninto\tO\nThursday\tO\n's\tO\nrace\tO\nin\tO\nsearch\tO\nof\tO\na\tO\nfirst\tO\ngroup\tO\none\tO\nsuccess\tO\nafter\tO\nmany\tO\nyears\tO\naround\tO\nthe\tO\ntop\tO\nof\tO\nhis\tO\nprofession\tO\n.\tO\n\nLike\tO\nPrescott\tO\n,\tO\nJack\tB-PER\nBerry\tI-PER\n,\tO\ntrainer\tT-0\nof\tO\nMind\tO\nGames\tO\n,\tO\nhad\tT-1\ngone\tT-1\ninto\tO\nThursday\tO\n's\tO\nrace\tO\nin\tO\nsearch\tO\nof\tO\na\tO\nfirst\tO\ngroup\tO\none\tO\nsuccess\tO\nafter\tO\nmany\tO\nyears\tO\naround\tO\nthe\tO\ntop\tO\nof\tO\nhis\tO\nprofession\tO\n.\tO\n\nLike\tO\nPrescott\tO\n,\tO\nJack\tT-0\nBerry\tT-0\n,\tO\ntrainer\tT-1\nof\tO\nMind\tB-PER\nGames\tI-PER\n,\tO\nhad\tO\ngone\tO\ninto\tO\nThursday\tO\n's\tO\nrace\tO\nin\tO\nsearch\tO\nof\tO\na\tO\nfirst\tO\ngroup\tO\none\tO\nsuccess\tO\nafter\tO\nmany\tO\nyears\tO\naround\tO\nthe\tO\ntop\tO\nof\tO\nhis\tO\nprofession\tO\n.\tO\n\nBerry\tB-PER\nsaid\tO\n:\tO\n\"\tO\nI`m\tT-0\ndisappointed\tT-1\nbut\tO\nI\tO\ndo\tO\nn't\tO\nfeel\tO\nsuicidal\tO\n.\tO\n\nHe\tT-0\n(\tO\nMind\tB-PER\nGames\tI-PER\n)\tO\nwas\tO\ngoing\tO\nas\tO\nwell\tT-1\nas\tO\nany\tO\nof\tO\nthem\tO\none\tO\nand\tO\na\tO\nhalf\tO\nfurlongs\tT-2\n(\tO\n300\tO\nmetres\tO\n)\tO\nout\tO\nbut\tO\nhe\tO\njust\tO\ndid\tO\nn't\tO\nquicken\tO\n.\tO\n\"\tO\n\nYORK\tB-LOC\n,\tO\nEngland\tT-0\n1996-08-22\tO\n\nYORK\tT-1\n,\tO\nEngland\tB-LOC\n1996-08-22\tT-0\n\nResult\tT-0\nof\tO\nthe\tO\nNunthorpe\tB-MISC\nStakes\tI-MISC\n,\tO\na\tO\ngroup\tO\none\tO\nrace\tO\nfor\tO\ntwo-year-olds\tO\nand\tO\nupwards\tO\n,\tO\nrun\tO\nover\tO\nfive\tO\nfurlongs\tT-1\n(\tO\n1\tO\nkm\tO\n)\tO\non\tO\nThursday\tO\n:\tO\n\n2.\tO\nEveningperformance\tB-PER\n16-1\tT-0\n(\tO\nChris\tO\nRutter\tO\n)\tO\n\n2.\tO\nEveningperformance\tO\n16-1\tT-0\n(\tT-0\nChris\tB-PER\nRutter\tI-PER\n)\tO\n\n3.\tO\nHever\tB-PER\nGolf\tI-PER\nRose\tI-PER\n11-4\tO\n(\tO\nJason\tT-0\nWeaver\tT-0\n)\tO\n\nFavourite\tT-1\n:\tO\nMind\tB-PER\nGames\tI-PER\n(\tO\n7-4\tO\n)\tO\nfinished\tT-0\n4th\tO\n\nWinner\tT-1\nowned\tT-3\nby\tO\nthe\tO\nCheveley\tB-ORG\nPark\tI-ORG\nStud\tI-ORG\nand\tO\ntrained\tT-2\nby\tO\nSir\tO\n\nMark\tB-PER\nPrescott\tI-PER\nat\tT-0\nNewmarket\tT-0\n.\tO\n\nMark\tT-1\nPrescott\tT-1\nat\tT-0\nNewmarket\tB-LOC\n.\tO\n\nTENNIS\tT-0\n-\tO\nRESULTS\tO\nAT\tO\nTOSHIBA\tB-MISC\nCLASSIC\tI-MISC\n.\tO\n\nCARLSBAD\tB-LOC\n,\tO\nCalifornia\tT-0\n1996-08-21\tO\n\nCARLSBAD\tT-0\n,\tO\nCalifornia\tB-LOC\n1996-08-21\tO\n\n$\tT-0\n450,000\tT-0\nToshiba\tB-MISC\nClassic\tI-MISC\ntennis\tO\ntournament\tT-1\non\tO\nWednesday\tO\n\n1\tO\n-\tO\nArantxa\tB-PER\nSanchez\tI-PER\nVicario\tI-PER\n(\tO\nSpain\tT-3\n)\tO\nbeat\tT-2\nNaoko\tT-0\nKijimuta\tT-1\n(\tO\nJapan\tO\n)\tO\n\n1\tO\n-\tO\nArantxa\tO\nSanchez\tO\nVicario\tO\n(\tO\nSpain\tB-LOC\n)\tO\nbeat\tO\nNaoko\tO\nKijimuta\tO\n(\tO\nJapan\tT-0\n)\tO\n\n1\tO\n-\tO\nArantxa\tT-0\nSanchez\tT-0\nVicario\tT-0\n(\tO\nSpain\tT-1\n)\tO\nbeat\tT-3\nNaoko\tB-PER\nKijimuta\tI-PER\n(\tO\nJapan\tT-2\n)\tO\n\n4\tO\n-\tO\nKimiko\tB-PER\nDate\tI-PER\n(\tO\nJapan\tT-1\n)\tO\nbeat\tT-0\nYone\tO\nKamio\tO\n(\tO\nJapan\tO\n)\tO\n6-2\tO\n7-5\tO\n\n4\tO\n-\tO\nKimiko\tO\nDate\tO\n(\tO\nJapan\tB-LOC\n)\tO\nbeat\tT-0\nYone\tT-1\nKamio\tT-1\n(\tO\nJapan\tO\n)\tO\n6-2\tO\n7-5\tO\n\n4\tO\n-\tO\nKimiko\tO\nDate\tT-0\n(\tO\nJapan\tO\n)\tO\nbeat\tT-1\nYone\tB-PER\nKamio\tI-PER\n(\tO\nJapan\tO\n)\tO\n6-2\tO\n7-5\tO\n\n4\tO\n-\tO\nKimiko\tT-0\nDate\tT-0\n(\tO\nJapan\tO\n)\tO\nbeat\tT-2\nYone\tT-1\nKamio\tT-1\n(\tO\nJapan\tB-LOC\n)\tO\n6-2\tO\n7-5\tO\n\nSandrine\tB-PER\nTestud\tI-PER\n(\tO\nFrance\tT-1\n)\tO\nbeat\tT-0\n7\tO\n-\tO\nAi\tO\nSugiyama\tO\n(\tO\nJapan\tT-2\n)\tO\n6-3\tO\n4-6\tO\n\nSandrine\tT-0\nTestud\tT-0\n(\tO\nFrance\tB-LOC\n)\tO\nbeat\tT-1\n7\tO\n-\tO\nAi\tO\nSugiyama\tO\n(\tO\nJapan\tO\n)\tO\n6-3\tO\n4-6\tO\n\nSandrine\tT-0\nTestud\tT-0\n(\tO\nFrance\tO\n)\tO\nbeat\tO\n7\tO\n-\tO\nAi\tB-PER\nSugiyama\tI-PER\n(\tO\nJapan\tO\n)\tO\n6-3\tO\n4-6\tO\n\nSandrine\tO\nTestud\tO\n(\tO\nFrance\tO\n)\tO\nbeat\tT-0\n7\tT-0\n-\tT-0\nAi\tT-0\nSugiyama\tT-0\n(\tO\nJapan\tB-LOC\n)\tO\n6-3\tO\n4-6\tO\n\n8\tO\n-\tO\nNathalie\tB-PER\nTauziat\tI-PER\n(\tO\nFrance\tT-0\n)\tO\nbeat\tO\nShi-Ting\tT-1\nWang\tT-1\n(\tO\nTaiwan\tO\n)\tO\n6-4\tO\n\n8\tO\n-\tO\nNathalie\tO\nTauziat\tO\n(\tO\nFrance\tB-LOC\n)\tO\nbeat\tO\nShi-Ting\tO\nWang\tO\n(\tO\nTaiwan\tT-0\n)\tO\n6-4\tO\n\n8\tO\n-\tO\nNathalie\tT-2\nTauziat\tT-2\n(\tO\nFrance\tT-0\n)\tO\nbeat\tT-3\nShi-Ting\tB-PER\nWang\tI-PER\n(\tO\nTaiwan\tT-1\n)\tO\n6-4\tO\n\n8\tO\n-\tO\nNathalie\tO\nTauziat\tO\n(\tO\nFrance\tO\n)\tO\nbeat\tT-0\nShi-Ting\tT-1\nWang\tT-1\n(\tO\nTaiwan\tB-LOC\n)\tO\n6-4\tO\n\nTENNIS\tT-0\n-\tO\nRESULTS\tO\nAT\tO\nHAMLET\tB-MISC\nCUP\tI-MISC\n.\tO\n\nCOMMACK\tB-LOC\n,\tO\nNew\tT-0\nYork\tT-0\n1996-08-21\tO\n\nCOMMACK\tT-0\n,\tO\nNew\tB-LOC\nYork\tI-LOC\n1996-08-21\tT-1\n\nWaldbaum\tB-MISC\nHamlet\tI-MISC\nCup\tI-MISC\ntennis\tT-0\ntournament\tT-1\non\tO\nWednesday\tO\n(\tO\nprefix\tO\n\n1\tO\n-\tO\nMichael\tB-PER\nChang\tI-PER\n(\tO\nU.S.\tO\n)\tO\nbeat\tT-1\nSergi\tT-0\nBruguera\tT-0\n(\tO\nSpain\tO\n)\tO\n6-3\tO\n6-2\tO\n\n1\tO\n-\tO\nMichael\tO\nChang\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tT-0\nSergi\tO\nBruguera\tO\n(\tO\nSpain\tO\n)\tO\n6-3\tO\n6-2\tO\n\n1\tO\n-\tO\nMichael\tT-0\nChang\tT-0\n(\tO\nU.S.\tO\n)\tO\nbeat\tT-2\nSergi\tB-PER\nBruguera\tI-PER\n(\tO\nSpain\tT-1\n)\tO\n6-3\tO\n6-2\tO\n\n1\tO\n-\tO\nMichael\tO\nChang\tO\n(\tO\nU.S.\tO\n)\tO\nbeat\tT-0\nSergi\tO\nBruguera\tO\n(\tO\nSpain\tB-LOC\n)\tO\n6-3\tO\n6-2\tO\n\nMichael\tB-PER\nJoyce\tI-PER\n(\tO\nU.S.\tT-2\n)\tO\nbeat\tO\n3\tO\n-\tO\nRichey\tT-0\nReneberg\tT-0\n(\tO\nU.S.\tT-1\n)\tO\n3-6\tO\n6-4\tO\n\nMichael\tT-0\nJoyce\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tT-2\n3\tO\n-\tO\nRichey\tO\nReneberg\tO\n(\tO\nU.S.\tT-1\n)\tO\n3-6\tO\n6-4\tT-1\n\nMichael\tT-1\nJoyce\tT-1\n(\tO\nU.S.\tO\n)\tO\nbeat\tO\n3\tO\n-\tO\nRichey\tB-PER\nReneberg\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n3-6\tO\n6-4\tO\n\nMichael\tT-0\nJoyce\tT-0\n(\tO\nU.S.\tT-1\n)\tO\nbeat\tO\n3\tO\n-\tO\nRichey\tO\nReneberg\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n3-6\tO\n6-4\tO\n\nMartin\tB-PER\nDamm\tI-PER\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\nbeat\tT-0\n6\tO\n-\tO\nYounes\tT-1\nEl\tT-1\nAynaoui\tT-1\n\nMartin\tT-0\nDamm\tT-0\n(\tT-0\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nbeat\tO\n6\tO\n-\tO\nYounes\tO\nEl\tO\nAynaoui\tO\n\nMartin\tO\nDamm\tO\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\nbeat\tT-0\n6\tT-0\n-\tO\nYounes\tB-PER\nEl\tI-PER\nAynaoui\tI-PER\n\nKarol\tB-PER\nKucera\tI-PER\n(\tO\nSlovakia\tO\n)\tO\nbeat\tT-0\nHicham\tT-1\nArazi\tT-1\n(\tO\nMorocco\tO\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n\nKarol\tT-2\nKucera\tT-2\n(\tO\nSlovakia\tB-LOC\n)\tO\nbeat\tT-1\nHicham\tT-3\nArazi\tT-3\n(\tO\nMorocco\tO\n)\tO\n7-6\tT-0\n(\tT-0\n7-4\tT-0\n)\tT-0\n\nKarol\tT-0\nKucera\tT-0\n(\tO\nSlovakia\tO\n)\tO\nbeat\tT-1\nHicham\tB-PER\nArazi\tI-PER\n(\tO\nMorocco\tO\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n\nKarol\tT-0\nKucera\tT-0\n(\tO\nSlovakia\tT-1\n)\tO\nbeat\tO\nHicham\tT-2\nArazi\tT-3\n(\tO\nMorocco\tB-LOC\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n\nSOCCER\tT-1\n-\tO\nDALGLISH\tB-PER\nSAD\tT-0\nOVER\tT-0\nBLACKBURN\tO\nPARTING\tO\n.\tO\n\nSOCCER\tT-0\n-\tO\nDALGLISH\tO\nSAD\tO\nOVER\tO\nBLACKBURN\tB-ORG\nPARTING\tT-1\n.\tO\n\nKenny\tB-PER\nDalglish\tI-PER\nspoke\tO\non\tO\nThursday\tO\nof\tO\nhis\tO\nsadness\tO\nat\tO\nleaving\tO\nBlackburn\tT-0\n,\tO\nthe\tO\nclub\tO\nhe\tO\nled\tO\nto\tO\nthe\tO\nEnglish\tO\npremier\tO\nleague\tO\ntitle\tO\nin\tO\n1994-95\tO\n.\tO\n\nKenny\tT-2\nDalglish\tT-2\nspoke\tT-0\non\tT-0\nThursday\tO\nof\tO\nhis\tO\nsadness\tO\nat\tO\nleaving\tT-1\nBlackburn\tB-ORG\n,\tO\nthe\tO\nclub\tO\nhe\tO\nled\tO\nto\tO\nthe\tO\nEnglish\tO\npremier\tO\nleague\tO\ntitle\tO\nin\tO\n1994-95\tO\n.\tO\n\nKenny\tO\nDalglish\tO\nspoke\tT-0\non\tO\nThursday\tO\nof\tO\nhis\tO\nsadness\tO\nat\tO\nleaving\tT-1\nBlackburn\tO\n,\tO\nthe\tO\nclub\tT-2\nhe\tO\nled\tO\nto\tO\nthe\tO\nEnglish\tB-MISC\npremier\tO\nleague\tO\ntitle\tO\nin\tO\n1994-95\tO\n.\tO\n\nBlackburn\tB-ORG\nannounced\tT-0\non\tO\nWednesday\tO\nthey\tT-2\nand\tT-2\nDalglish\tT-2\nhad\tO\nparted\tO\nby\tO\nmutual\tO\nconsent\tO\n.\tO\n\nBlackburn\tT-3\nannounced\tO\non\tO\nWednesday\tT-4\nthey\tT-1\nand\tT-1\nDalglish\tB-PER\nhad\tT-2\nparted\tT-2\nby\tO\nmutual\tT-5\nconsent\tT-5\n.\tO\n\nBut\tO\nthe\tO\nex-manager\tO\nconfessed\tT-1\non\tO\nThursday\tO\nto\tO\nbeing\tO\n\"\tO\nsad\tO\n\"\tO\nat\tO\nleaving\tO\nafter\tO\ntaking\tO\nBlackburn\tB-ORG\nfrom\tO\nthe\tO\nsecond\tO\ndivision\tT-0\nto\tO\nthe\tO\npremier\tO\nleague\tO\ntitle\tO\ninside\tO\nthree\tO\nand\tO\na\tO\nhalf\tO\nyears\tO\n.\tO\n\nIn\tO\na\tO\ntelephone\tO\ncall\tO\nto\tO\na\tO\nlocal\tO\nnewspaper\tO\nfrom\tO\nhis\tO\nholiday\tO\nhome\tO\nin\tT-2\nSpain\tB-LOC\n,\tO\nDalglish\tT-3\nsaid\tO\n:\tO\n\"\tO\nWe\tO\ncame\tO\nto\tO\nthe\tO\nsame\tO\nopinion\tO\n,\tO\nalbeit\tT-0\nthe\tO\nclub\tO\ncame\tO\nto\tO\nit\tO\na\tO\nlittle\tO\nbit\tO\nearlier\tO\nthan\tO\nme\tT-1\n.\tO\n\"\tO\n\nIn\tO\na\tO\ntelephone\tO\ncall\tO\nto\tO\na\tO\nlocal\tT-0\nnewspaper\tT-0\nfrom\tO\nhis\tO\nholiday\tO\nhome\tO\nin\tO\nSpain\tT-1\n,\tO\nDalglish\tB-PER\nsaid\tO\n:\tO\n\"\tO\nWe\tO\ncame\tO\nto\tO\nthe\tO\nsame\tO\nopinion\tO\n,\tO\nalbeit\tO\nthe\tO\nclub\tO\ncame\tO\nto\tO\nit\tO\na\tO\nlittle\tO\nbit\tO\nearlier\tO\nthan\tO\nme\tO\n.\tO\n\"\tO\n\nDalglish\tB-PER\nhad\tT-2\nbeen\tT-2\nwith\tT-2\nBlackburn\tT-0\nfor\tO\nnearly\tO\nfive\tO\nyears\tO\n,\tO\nfirst\tO\nas\tO\nmanager\tO\nand\tO\nthen\tO\n,\tO\nfor\tO\nthe\tO\npast\tT-1\n15\tO\nmonths\tO\n,\tO\nas\tO\ndirector\tT-3\nof\tO\nfootball\tO\n.\tO\n\nDalglish\tO\nhad\tT-1\nbeen\tT-1\nwith\tT-1\nBlackburn\tB-ORG\nfor\tO\nnearly\tO\nfive\tO\nyears\tO\n,\tO\nfirst\tO\nas\tO\nmanager\tT-0\nand\tO\nthen\tO\n,\tO\nfor\tO\nthe\tO\npast\tO\n15\tO\nmonths\tO\n,\tO\nas\tO\ndirector\tO\nof\tO\nfootball\tO\n.\tO\n\nCRICKET\tT-0\n-\tO\nENGLISH\tB-MISC\nCOUNTY\tI-MISC\nCHAMPIONSHIP\tI-MISC\nSCORES\tT-1\n.\tO\n\nEnglish\tB-MISC\nCounty\tO\nChampionship\tT-0\ncricket\tT-1\nmatches\tT-1\non\tO\nThursday\tO\n:\tO\n\nAt\tO\nWeston-super-Mare\tB-LOC\n:\tO\nDurham\tT-0\n326\tO\n(\tO\nD.\tO\nCox\tO\n95\tO\nnot\tO\nout\tO\n,\tO\n\nAt\tO\nWeston-super-Mare\tO\n:\tO\nDurham\tT-1\n326\tO\n(\tO\nD.\tB-PER\nCox\tI-PER\n95\tO\nnot\tT-0\nout\tT-0\n,\tO\n\nS.\tB-PER\nCampbell\tI-PER\n69\tO\n;\tO\nG.\tT-0\nRose\tT-1\n7-73\tO\n)\tO\n.\tO\n\nS.\tT-0\nCampbell\tO\n69\tO\n;\tO\nG.\tB-PER\nRose\tI-PER\n7-73\tO\n)\tO\n.\tT-0\n\nSomerset\tT-0\n236-4\tO\n(\tO\nM.\tB-PER\nLathwell\tI-PER\n85\tO\n)\tO\n.\tO\n\nAt\tT-0\nColchester\tB-LOC\n:\tO\nGloucestershire\tT-1\n280\tO\n(\tO\nJ.\tO\nRussell\tO\n63\tO\n,\tO\nA.\tO\nSymonds\tO\n\nAt\tT-0\nColchester\tT-1\n:\tO\nGloucestershire\tB-ORG\n280\tO\n(\tO\nJ.\tO\nRussell\tO\n63\tO\n,\tO\nA.\tO\nSymonds\tO\n\nAt\tO\nColchester\tO\n:\tO\nGloucestershire\tT-0\n280\tO\n(\tO\nJ.\tB-PER\nRussell\tI-PER\n63\tO\n,\tO\nA.\tO\nSymonds\tO\n\nAt\tO\nColchester\tO\n:\tO\nGloucestershire\tT-0\n280\tO\n(\tO\nJ.\tT-1\nRussell\tT-1\n63\tT-1\n,\tO\nA.\tB-PER\nSymonds\tI-PER\n\nEssex\tB-ORG\n72-0\tT-0\n.\tT-0\n\nAt\tT-1\nCardiff\tB-LOC\n:\tO\nKent\tT-0\n128-1\tO\n(\tO\nM.\tO\nWalker\tO\n59\tO\n,\tO\nD.\tO\nFulton\tO\n53\tO\nnot\tO\nout\tO\n)\tO\nv\tO\n\nAt\tO\nCardiff\tT-0\n:\tO\nKent\tB-ORG\n128-1\tO\n(\tO\nM.\tO\nWalker\tO\n59\tO\n,\tO\nD.\tO\nFulton\tO\n53\tO\nnot\tO\nout\tO\n)\tO\nv\tO\n\nAt\tT-0\nCardiff\tT-0\n:\tO\nKent\tO\n128-1\tO\n(\tO\nM.\tB-PER\nWalker\tI-PER\n59\tT-2\n,\tO\nD.\tO\nFulton\tO\n53\tO\nnot\tT-1\nout\tT-1\n)\tO\nv\tO\n\nAt\tO\nCardiff\tO\n:\tO\nKent\tT-1\n128-1\tO\n(\tO\nM.\tT-2\nWalker\tT-2\n59\tO\n,\tO\nD.\tB-PER\nFulton\tI-PER\n53\tT-0\nnot\tT-0\nout\tT-0\n)\tO\nv\tO\n\nGlamorgan\tB-ORG\n.\tT-0\n\nAt\tT-0\nLeicester\tB-LOC\n:\tO\nLeicestershire\tO\n343-8\tO\n(\tO\nP.\tO\nSimmons\tO\n108\tO\n,\tO\nP.\tO\nNixon\tO\n\nAt\tO\nLeicester\tO\n:\tO\nLeicestershire\tB-ORG\n343-8\tO\n(\tO\nP.\tT-0\nSimmons\tT-0\n108\tO\n,\tO\nP.\tT-1\nNixon\tT-1\n\nAt\tT-2\nLeicester\tO\n:\tO\nLeicestershire\tT-0\n343-8\tO\n(\tO\nP.\tT-1\nSimmons\tT-1\n108\tO\n,\tO\nP.\tB-PER\nNixon\tI-PER\n\nAt\tT-1\nNorthampton\tB-LOC\n:\tO\nSussex\tT-0\n368-7\tO\n(\tO\nN.\tO\nLenham\tO\n145\tO\n,\tO\nV.\tO\nDrakes\tO\n59\tO\nnot\tO\n\nAt\tT-0\nNorthampton\tT-1\n:\tO\nSussex\tB-ORG\n368-7\tO\n(\tO\nN.\tO\nLenham\tO\n145\tO\n,\tO\nV.\tO\nDrakes\tO\n59\tO\nnot\tO\n\nAt\tO\nNorthampton\tT-0\n:\tO\nSussex\tT-1\n368-7\tO\n(\tO\nN.\tB-PER\nLenham\tI-PER\n145\tT-2\n,\tO\nV.\tO\nDrakes\tO\n59\tO\nnot\tO\n\nAt\tO\nNorthampton\tT-0\n:\tO\nSussex\tO\n368-7\tO\n(\tO\nN.\tT-1\nLenham\tT-1\n145\tT-1\n,\tO\nV.\tB-PER\nDrakes\tI-PER\n59\tO\nnot\tO\n\nout\tO\n,\tO\nA.\tB-PER\nWells\tI-PER\n51\tO\n)\tO\nv\tT-1\nNorthamptonshire\tT-0\n.\tO\n\nout\tO\n,\tO\nA.\tT-1\nWells\tT-1\n51\tO\n)\tO\nv\tT-2\nNorthamptonshire\tB-ORG\n.\tO\n\nAt\tT-0\nTrent\tB-LOC\nBridge\tI-LOC\n:\tO\nNottinghamshire\tO\n392-6\tO\n(\tO\nG.\tO\nArcher\tO\n143\tO\nnot\tO\n\nAt\tT-0\nTrent\tO\nBridge\tO\n:\tO\nNottinghamshire\tB-ORG\n392-6\tO\n(\tO\nG.\tO\nArcher\tO\n143\tO\nnot\tO\n\nAt\tO\nTrent\tT-0\nBridge\tT-0\n:\tO\nNottinghamshire\tO\n392-6\tO\n(\tO\nG.\tB-PER\nArcher\tI-PER\n143\tO\nnot\tO\n\nout\tO\n,\tO\nM.\tB-PER\nDowman\tI-PER\n107\tO\n)\tO\nv\tT-0\nSurrey\tO\n.\tO\n\nout\tO\n,\tO\nM.\tO\nDowman\tO\n107\tO\n)\tO\nv\tT-0\nSurrey\tB-ORG\n.\tO\n\nAt\tT-1\nWorcester\tB-LOC\n:\tO\nWarwickshire\tT-0\n255-9\tO\n(\tO\nA.\tO\nGiles\tO\n57\tO\nnot\tO\nout\tO\n,\tO\nW.\tO\nKhan\tO\n\nAt\tO\nWorcester\tO\n:\tO\nWarwickshire\tT-0\n255-9\tO\n(\tO\nA.\tB-PER\nGiles\tI-PER\n57\tO\nnot\tO\nout\tO\n,\tO\nW.\tO\nKhan\tO\n\nAt\tO\nWorcester\tT-1\n:\tO\nWarwickshire\tO\n255-9\tO\n(\tO\nA.\tO\nGiles\tO\n57\tO\nnot\tT-0\nout\tT-0\n,\tO\nW.\tB-PER\nKhan\tI-PER\n\n52\tO\n)\tO\nv\tT-0\nWorcestershire\tB-ORG\n.\tT-1\n\nAt\tT-0\nHeadingley\tB-LOC\n:\tO\nYorkshire\tT-1\n305-5\tO\n(\tO\nC.\tO\nWhite\tO\n66\tO\nnot\tO\nout\tO\n,\tO\nM.\tO\nMoxon\tO\n\nAt\tO\nHeadingley\tT-1\n:\tO\nYorkshire\tB-ORG\n305-5\tT-0\n(\tO\nC.\tO\nWhite\tO\n66\tO\nnot\tO\nout\tO\n,\tO\nM.\tO\nMoxon\tO\n\nAt\tT-2\nHeadingley\tO\n:\tO\nYorkshire\tT-0\n305-5\tO\n(\tO\nC.\tB-PER\nWhite\tI-PER\n66\tO\nnot\tO\nout\tT-3\n,\tO\nM.\tT-1\nMoxon\tT-1\n\n66\tO\n,\tO\nM.\tB-PER\nVaughan\tI-PER\n57\tT-0\n)\tO\nv\tO\nLancashire\tT-1\n.\tO\n\nCRICKET\tO\n-\tO\nENGLAND\tB-LOC\nV\tO\nPAKISTAN\tT-0\nFINAL\tT-1\nTEST\tO\nSCOREBOARD\tO\n.\tO\n\nCRICKET\tO\n-\tO\nENGLAND\tT-0\nV\tT-1\nPAKISTAN\tB-LOC\nFINAL\tO\nTEST\tO\nSCOREBOARD\tO\n.\tO\n\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nbetween\tO\nEngland\tB-LOC\nand\tT-0\nPakistan\tT-0\nat\tT-0\nThe\tT-0\nOval\tT-0\non\tO\n\nthird\tT-2\nand\tO\nfinal\tT-3\ntest\tO\nbetween\tO\nEngland\tO\nand\tO\nPakistan\tB-LOC\nat\tT-1\nThe\tO\nOval\tT-0\non\tO\n\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nbetween\tO\nEngland\tO\nand\tO\nPakistan\tT-0\nat\tO\nThe\tB-LOC\nOval\tI-LOC\non\tO\n\nEngland\tB-LOC\nfirst\tT-0\ninnings\tO\n\nM.\tB-PER\nAtherton\tI-PER\nb\tT-0\nWaqar\tT-1\nYounis\tT-2\n31\tO\n\nM.\tT-0\nAtherton\tT-0\nb\tO\nWaqar\tB-PER\nYounis\tI-PER\n31\tO\n\nA.\tB-PER\nStewart\tI-PER\nb\tO\nMushtaq\tT-0\nAhmed\tT-0\n44\tO\n\nA.\tO\nStewart\tT-1\nb\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n44\tT-0\n\nN.\tB-PER\nHussain\tI-PER\nc\tT-0\nSaeed\tT-1\nAnwar\tT-1\nb\tO\nWaqar\tO\nYounis\tO\n12\tO\n\nN.\tT-0\nHussain\tT-0\nc\tO\nSaeed\tB-PER\nAnwar\tI-PER\nb\tO\nWaqar\tO\nYounis\tO\n12\tO\n\nN.\tO\nHussain\tO\nc\tO\nSaeed\tT-0\nAnwar\tT-0\nb\tT-1\nWaqar\tB-PER\nYounis\tI-PER\n12\tO\n\nG.\tB-PER\nThorpe\tI-PER\nlbw\tT-0\nb\tT-1\nMohammad\tT-3\nAkram\tT-4\n54\tO\n\nG.\tO\nThorpe\tO\nlbw\tT-1\nb\tO\nMohammad\tB-PER\nAkram\tI-PER\n54\tT-0\n\nJ.\tB-PER\nCrawley\tI-PER\nnot\tT-0\nout\tT-0\n94\tT-0\n\nN.\tB-PER\nKnight\tI-PER\nb\tO\nMushtaq\tO\nAhmed\tT-0\n17\tO\n\nN.\tT-0\nKnight\tT-0\nb\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n17\tO\n\nC.\tB-PER\nLewis\tI-PER\nb\tO\nWasim\tT-0\nAkram\tT-0\n5\tO\n\nC.\tO\nLewis\tT-0\nb\tT-0\nWasim\tB-PER\nAkram\tI-PER\n5\tO\n\nTo\tT-0\nbat\tT-0\n:\tO\nR.\tB-PER\nCroft\tI-PER\n,\tO\nD.\tO\nCork\tO\n,\tO\nA.\tO\nMullally\tO\n\nTo\tO\nbat\tO\n:\tO\nR.\tT-0\nCroft\tT-0\n,\tO\nD.\tB-PER\nCork\tI-PER\n,\tO\nA.\tO\nMullally\tO\n\nBowling\tT-1\n(\tO\nto\tO\ndate\tO\n)\tO\n:\tO\nWasim\tB-PER\nAkram\tI-PER\n25-8-61-1\tT-0\n,\tO\nWaqar\tT-2\nYounis\tT-2\n\n20-6-70-2\tT-0\n,\tO\nMohammad\tB-PER\nAkram\tI-PER\n12-1-41-1\tO\n,\tO\nMushtaq\tT-1\nAhmed\tT-1\n27-5-78-2\tO\n,\tO\n\n20-6-70-2\tO\n,\tO\nMohammad\tT-1\nAkram\tT-1\n12-1-41-1\tO\n,\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n27-5-78-2\tO\n,\tT-0\n\nPakistan\tB-LOC\n:\tO\nAamir\tT-0\nSohail\tT-0\n,\tO\nSaeed\tO\nAnwar\tO\n,\tO\nIjaz\tO\nAhmed\tO\n,\tO\n\nPakistan\tT-0\n:\tO\nAamir\tB-PER\nSohail\tI-PER\n,\tO\nSaeed\tT-1\nAnwar\tT-1\n,\tO\nIjaz\tO\nAhmed\tO\n,\tO\n\nPakistan\tT-0\n:\tO\nAamir\tO\nSohail\tO\n,\tO\nSaeed\tB-PER\nAnwar\tI-PER\n,\tO\nIjaz\tO\nAhmed\tO\n,\tO\n\nPakistan\tO\n:\tO\nAamir\tT-0\nSohail\tT-0\n,\tO\nSaeed\tO\nAnwar\tO\n,\tO\nIjaz\tB-PER\nAhmed\tI-PER\n,\tO\n\nInzamam-ul-Haq\tO\n,\tO\nSalim\tB-PER\nMalik\tI-PER\n,\tO\nAsif\tT-0\nMujtaba\tT-0\n,\tO\nWasim\tT-1\nAkram\tT-1\n,\tO\nMoin\tO\n\nInzamam-ul-Haq\tO\n,\tO\nSalim\tT-0\nMalik\tT-0\n,\tO\nAsif\tB-PER\nMujtaba\tI-PER\n,\tO\nWasim\tT-1\nAkram\tT-1\n,\tO\nMoin\tO\n\nInzamam-ul-Haq\tT-1\n,\tO\nSalim\tO\nMalik\tO\n,\tO\nAsif\tO\nMujtaba\tO\n,\tO\nWasim\tB-PER\nAkram\tI-PER\n,\tO\nMoin\tT-0\n\nInzamam-ul-Haq\tT-0\n,\tO\nSalim\tO\nMalik\tO\n,\tO\nAsif\tO\nMujtaba\tO\n,\tO\nWasim\tO\nAkram\tO\n,\tO\nMoin\tB-PER\n\nKhan\tO\n,\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n,\tO\nWaqar\tO\nYounis\tO\n,\tO\nMohammad\tT-0\nAkam\tT-0\n\nKhan\tO\n,\tO\nMushtaq\tT-0\nAhmed\tT-0\n,\tT-0\nWaqar\tB-PER\nYounis\tI-PER\n,\tO\nMohammad\tT-1\nAkam\tO\n\nSOCCER\tT-0\n-\tO\nFERGUSON\tB-PER\nBACK\tO\nIN\tO\nSCOTTISH\tO\nSQUAD\tT-1\nAFTER\tO\n20\tO\nMONTHS\tO\n.\tO\n\nSOCCER\tT-0\n-\tO\nFERGUSON\tO\nBACK\tO\nIN\tT-1\nSCOTTISH\tB-MISC\nSQUAD\tT-2\nAFTER\tO\n20\tO\nMONTHS\tO\n.\tO\n\nEverton\tB-ORG\n's\tO\nDuncan\tO\nFerguson\tT-0\n,\tO\nwho\tO\nscored\tT-2\ntwice\tO\nagainst\tT-3\nManchester\tO\nUnited\tO\non\tO\nWednesday\tO\n,\tO\nwas\tO\npicked\tO\non\tO\nThursday\tO\nfor\tO\nthe\tO\nScottish\tT-1\nsquad\tO\nafter\tO\na\tO\n20-month\tO\nexile\tO\n.\tO\n\nEverton\tO\n's\tO\nDuncan\tB-PER\nFerguson\tI-PER\n,\tO\nwho\tO\nscored\tO\ntwice\tO\nagainst\tT-2\nManchester\tT-1\nUnited\tT-1\non\tO\nWednesday\tO\n,\tO\nwas\tO\npicked\tT-0\non\tO\nThursday\tO\nfor\tO\nthe\tO\nScottish\tO\nsquad\tO\nafter\tO\na\tO\n20-month\tO\nexile\tO\n.\tT-2\n\nEverton\tT-1\n's\tT-1\nDuncan\tT-1\nFerguson\tT-1\n,\tO\nwho\tO\nscored\tT-0\ntwice\tT-0\nagainst\tT-0\nManchester\tB-ORG\nUnited\tI-ORG\non\tO\nWednesday\tO\n,\tO\nwas\tO\npicked\tO\non\tO\nThursday\tO\nfor\tO\nthe\tO\nScottish\tO\nsquad\tT-2\nafter\tO\na\tO\n20-month\tO\nexile\tO\n.\tO\n\nEverton\tO\n's\tO\nDuncan\tO\nFerguson\tO\n,\tO\nwho\tO\nscored\tT-0\ntwice\tO\nagainst\tO\nManchester\tO\nUnited\tO\non\tO\nWednesday\tO\n,\tO\nwas\tO\npicked\tO\non\tO\nThursday\tO\nfor\tT-1\nthe\tT-1\nScottish\tB-MISC\nsquad\tT-2\nafter\tO\na\tO\n20-month\tO\nexile\tO\n.\tO\n\nGlasgow\tB-ORG\nRangers\tI-ORG\nstriker\tT-0\nAlly\tT-0\nMcCoist\tT-0\n,\tO\nanother\tO\nman\tO\nin\tO\nform\tO\nafter\tO\ntwo\tO\nhat-tricks\tO\nin\tO\nfour\tO\ndays\tO\n,\tO\nwas\tO\nalso\tO\nnamed\tO\nfor\tO\nthe\tO\nAugust\tO\n31\tO\nWorld\tO\nCup\tO\nqualifier\tO\nagainst\tO\nAustria\tO\nin\tO\nVienna\tO\n.\tO\n\nGlasgow\tT-3\nRangers\tT-3\nstriker\tT-2\nAlly\tB-PER\nMcCoist\tI-PER\n,\tO\nanother\tO\nman\tO\nin\tO\nform\tO\nafter\tO\ntwo\tO\nhat-tricks\tO\nin\tO\nfour\tO\ndays\tO\n,\tO\nwas\tO\nalso\tO\nnamed\tT-0\nfor\tO\nthe\tO\nAugust\tO\n31\tO\nWorld\tO\nCup\tO\nqualifier\tO\nagainst\tT-1\nAustria\tO\nin\tO\nVienna\tO\n.\tO\n\nGlasgow\tT-1\nRangers\tO\nstriker\tO\nAlly\tO\nMcCoist\tO\n,\tO\nanother\tO\nman\tO\nin\tO\nform\tO\nafter\tO\ntwo\tO\nhat-tricks\tO\nin\tO\nfour\tO\ndays\tO\n,\tO\nwas\tO\nalso\tO\nnamed\tO\nfor\tO\nthe\tO\nAugust\tO\n31\tO\nWorld\tB-MISC\nCup\tI-MISC\nqualifier\tT-0\nagainst\tT-0\nAustria\tT-0\nin\tT-0\nVienna\tT-0\n.\tO\n\nGlasgow\tO\nRangers\tO\nstriker\tO\nAlly\tT-0\nMcCoist\tT-0\n,\tO\nanother\tO\nman\tO\nin\tO\nform\tO\nafter\tO\ntwo\tO\nhat-tricks\tO\nin\tO\nfour\tO\ndays\tO\n,\tO\nwas\tO\nalso\tO\nnamed\tT-1\nfor\tO\nthe\tO\nAugust\tO\n31\tO\nWorld\tO\nCup\tO\nqualifier\tO\nagainst\tT-2\nAustria\tB-LOC\nin\tO\nVienna\tO\n.\tO\n\nGlasgow\tO\nRangers\tO\nstriker\tO\nAlly\tO\nMcCoist\tO\n,\tO\nanother\tO\nman\tO\nin\tO\nform\tO\nafter\tO\ntwo\tO\nhat-tricks\tO\nin\tO\nfour\tO\ndays\tO\n,\tO\nwas\tO\nalso\tO\nnamed\tO\nfor\tO\nthe\tO\nAugust\tO\n31\tO\nWorld\tT-1\nCup\tT-1\nqualifier\tO\nagainst\tO\nAustria\tO\nin\tT-0\nVienna\tB-LOC\n.\tO\n\nFerguson\tB-PER\n,\tO\nwho\tT-1\nserved\tO\nsix\tO\nweeks\tO\nin\tO\njail\tT-0\nin\tO\nlate\tO\n1995\tO\nfor\tO\nhead-butting\tO\nan\tO\nopponent\tO\n,\tO\nwon\tO\nthe\tO\nlast\tO\nof\tO\nhis\tO\nfive\tO\nScotland\tO\ncaps\tO\nin\tO\nDecember\tO\n1994\tO\n.\tO\n\nFerguson\tT-1\n,\tO\nwho\tO\nserved\tO\nsix\tO\nweeks\tO\nin\tO\njail\tO\nin\tO\nlate\tO\n1995\tO\nfor\tO\nhead-butting\tT-2\nan\tO\nopponent\tO\n,\tO\nwon\tT-3\nthe\tO\nlast\tO\nof\tO\nhis\tO\nfive\tO\nScotland\tB-LOC\ncaps\tT-0\nin\tO\nDecember\tO\n1994\tO\n.\tO\n\nScotland\tB-LOC\nmanager\tT-2\nCraig\tT-2\nBrown\tT-2\nsaid\tT-1\non\tO\nThursday\tO\n:\tO\n\"\tO\nI\tO\n've\tO\nwatched\tO\nDuncan\tO\nFerguson\tO\nin\tO\naction\tO\ntwice\tO\nrecently\tO\nand\tO\nhe\tO\n's\tO\nbang\tO\nin\tO\nform\tO\n.\tO\n\nScotland\tT-1\nmanager\tT-1\nCraig\tB-PER\nBrown\tI-PER\nsaid\tO\non\tO\nThursday\tO\n:\tO\n\"\tO\nI\tO\n've\tO\nwatched\tT-0\nDuncan\tO\nFerguson\tO\nin\tO\naction\tO\ntwice\tO\nrecently\tO\nand\tO\nhe\tO\n's\tO\nbang\tO\nin\tO\nform\tO\n.\tO\n\nScotland\tO\nmanager\tT-0\nCraig\tO\nBrown\tO\nsaid\tO\non\tO\nThursday\tO\n:\tO\n\"\tO\nI\tO\n've\tO\nwatched\tO\nDuncan\tB-PER\nFerguson\tI-PER\nin\tO\naction\tO\ntwice\tO\nrecently\tO\nand\tO\nhe\tO\n's\tO\nbang\tO\nin\tO\nform\tO\n.\tO\n\nAlly\tB-PER\nMcCoist\tI-PER\nis\tO\nalso\tO\nin\tO\ngreat\tT-0\nscoring\tO\nform\tO\nat\tO\nthe\tO\nmoment\tO\n.\tO\n\"\tO\n\nCeltic\tB-ORG\n's\tO\nJackie\tT-1\nMcNamara\tT-1\n,\tO\nwho\tO\ndid\tO\nwell\tO\nwith\tO\nlast\tO\nseason\tT-0\n's\tO\nsuccessful\tO\nunder-21\tO\nteam\tO\n,\tO\nearns\tO\na\tO\ncall-up\tO\nto\tO\nthe\tO\nsenior\tT-2\nsquad\tT-2\n.\tO\n\nCeltic\tT-1\n's\tO\nJackie\tB-PER\nMcNamara\tI-PER\n,\tO\nwho\tO\ndid\tO\nwell\tO\nwith\tO\nlast\tO\nseason\tO\n's\tO\nsuccessful\tO\nunder-21\tO\nteam\tO\n,\tO\nearns\tO\na\tO\ncall-up\tT-2\nto\tO\nthe\tO\nsenior\tO\nsquad\tT-0\n.\tO\n\nCRICKET\tT-0\n-\tO\nENGLAND\tB-LOC\n100-2\tO\nAT\tO\nLUNCH\tO\nON\tO\nFIRST\tO\nDAY\tO\nOF\tO\nTHIRD\tO\nTEST\tO\n.\tO\n\nEngland\tB-LOC\nwere\tO\n100\tO\nfor\tO\ntwo\tO\nat\tO\nlunch\tT-2\non\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\nthe\tO\nthird\tO\nand\tO\nfinal\tT-3\ntest\tT-3\nagainst\tT-1\nPakistan\tT-0\nat\tO\nThe\tO\nOval\tO\non\tO\nThursday\tO\n.\tO\n\nEngland\tT-0\nwere\tO\n100\tO\nfor\tO\ntwo\tO\nat\tO\nlunch\tO\non\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\nthe\tO\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nagainst\tT-1\nPakistan\tB-LOC\nat\tT-2\nThe\tO\nOval\tO\non\tO\nThursday\tO\n.\tT-1\n\nEngland\tT-1\nwere\tO\n100\tO\nfor\tO\ntwo\tO\nat\tO\nlunch\tO\non\tO\nthe\tO\nfirst\tO\nday\tO\nof\tO\nthe\tO\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nagainst\tO\nPakistan\tT-2\nat\tO\nThe\tB-LOC\nOval\tI-LOC\non\tT-0\nThursday\tT-0\n.\tO\n\nSOCCER\tT-0\n-\tO\nKEANE\tB-PER\nSIGNS\tO\nFOUR-YEAR\tO\nCONTRACT\tO\nWITH\tO\nMANCHESTER\tT-1\nUNITED\tT-1\n.\tO\n\nSOCCER\tO\n-\tO\nKEANE\tT-1\nSIGNS\tT-2\nFOUR-YEAR\tO\nCONTRACT\tT-0\nWITH\tO\nMANCHESTER\tB-LOC\nUNITED\tI-LOC\n.\tO\n\nIreland\tB-LOC\nmidfielder\tO\nRoy\tT-2\nKeane\tT-2\nhas\tO\nsigned\tT-0\na\tO\nnew\tO\nfour-year\tO\ncontract\tO\nwith\tO\nEnglish\tO\nleague\tO\nand\tO\nF.A.\tT-1\nCup\tT-1\nchampions\tT-1\nManchester\tT-1\nUnited\tT-1\n.\tO\n\nIreland\tO\nmidfielder\tO\nRoy\tB-PER\nKeane\tI-PER\nhas\tT-0\nsigned\tT-0\na\tT-0\nnew\tT-0\nfour-year\tT-0\ncontract\tT-0\nwith\tO\nEnglish\tO\nleague\tO\nand\tO\nF.A.\tO\nCup\tO\nchampions\tO\nManchester\tO\nUnited\tO\n.\tO\n\nIreland\tO\nmidfielder\tT-0\nRoy\tT-1\nKeane\tT-1\nhas\tO\nsigned\tO\na\tO\nnew\tO\nfour-year\tT-2\ncontract\tT-3\nwith\tT-3\nEnglish\tB-MISC\nleague\tO\nand\tO\nF.A.\tO\nCup\tO\nchampions\tO\nManchester\tO\nUnited\tO\n.\tO\n\nIreland\tO\nmidfielder\tO\nRoy\tT-3\nKeane\tT-3\nhas\tO\nsigned\tT-0\na\tO\nnew\tO\nfour-year\tO\ncontract\tT-1\nwith\tO\nEnglish\tO\nleague\tO\nand\tO\nF.A.\tB-MISC\nCup\tI-MISC\nchampions\tO\nManchester\tT-2\nUnited\tT-2\n.\tO\n\nIreland\tO\nmidfielder\tT-0\nRoy\tT-1\nKeane\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)\tO\nbeat\tO\n11\tO\n-\tO\nAlberto\tT-0\nBerasategui\tO\n\nPatrick\tO\nRafter\tO\n(\tO\nAustralia\tB-LOC\n)\tO\nbeat\tT-0\n11\tO\n-\tO\nAlberto\tO\nBerasategui\tO\n\nPatrick\tO\nRafter\tO\n(\tO\nAustralia\tT-0\n)\tO\nbeat\tT-1\n11\tO\n-\tO\nAlberto\tB-PER\nBerasategui\tI-PER\n\n(\tO\nSpain\tB-LOC\n)\tO\n6-1\tT-0\n6-2\tT-1\n\nPetr\tB-PER\nKorda\tI-PER\n(\tO\nCzech\tT-0\nRepublic\tT-0\n)\tO\nbeat\tT-2\n12\tO\n-\tO\nFrancisco\tO\nClavet\tO\n(\tO\nSpain\tT-1\n)\tO\n\nPetr\tT-0\nKorda\tT-0\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nbeat\tT-1\n12\tO\n-\tO\nFrancisco\tO\nClavet\tO\n(\tO\nSpain\tT-2\n)\tO\n\nPetr\tO\nKorda\tO\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\nbeat\tO\n12\tO\n-\tO\nFrancisco\tT-0\nClavet\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n\nDaniel\tB-PER\nVacek\tI-PER\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\nbeat\tO\n13\tO\n-\tO\nJason\tT-0\nStoltenberg\tT-0\n\nDaniel\tT-0\nVacek\tT-0\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nbeat\tO\n13\tO\n-\tO\nJason\tO\nStoltenberg\tO\n\nDaniel\tO\nVacek\tO\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\nbeat\tT-0\n13\tO\n-\tO\nJason\tB-PER\nStoltenberg\tI-PER\n\n(\tO\nAustralia\tB-LOC\n)\tO\n5-7\tT-0\n7-6\tT-0\n(\tT-0\n7-1\tT-0\n)\tT-0\n7-6\tT-1\n(\tT-1\n13-11\tT-1\n)\tT-1\n\nTodd\tB-PER\nWoodbridge\tI-PER\n(\tO\nAustralia\tO\nbeat\tT-0\nSebastien\tT-1\nLareau\tT-1\n(\tO\nCanada\tO\n)\tO\n6-3\tO\n\nTodd\tT-2\nWoodbridge\tT-2\n(\tO\nAustralia\tB-LOC\nbeat\tO\nSebastien\tO\nLareau\tO\n(\tT-1\nCanada\tT-1\n)\tT-1\n6-3\tO\n\nTodd\tO\nWoodbridge\tO\n(\tO\nAustralia\tT-0\nbeat\tT-1\nSebastien\tB-PER\nLareau\tI-PER\n(\tO\nCanada\tO\n)\tO\n6-3\tO\n\nTodd\tT-2\nWoodbridge\tO\n(\tO\nAustralia\tT-0\nbeat\tO\nSebastien\tT-1\nLareau\tT-1\n(\tO\nCanada\tB-LOC\n)\tO\n6-3\tO\n\nAlex\tO\nO'Brien\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tT-0\nByron\tO\nBlack\tO\n(\tO\nZimbabwe\tO\n)\tO\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n6-2\tO\n\nAlex\tO\nO'Brien\tO\n(\tO\nU.S.\tO\n)\tO\nbeat\tT-0\nByron\tB-PER\nBlack\tI-PER\n(\tO\nZimbabwe\tT-1\n)\tO\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n6-2\tO\n\nAlex\tO\nO'Brien\tO\n(\tO\nU.S.\tT-0\n)\tO\nbeat\tO\nByron\tO\nBlack\tO\n(\tO\nZimbabwe\tB-LOC\n)\tO\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n6-2\tO\n\nBohdan\tB-PER\nUlihrach\tI-PER\n(\tO\nCzech\tO\nRepublic\tT-0\n)\tO\nbeat\tT-1\nAndrea\tT-2\nGaudenzi\tT-2\n(\tO\nItaly\tO\n)\tO\n\nBohdan\tT-0\nUlihrach\tT-0\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nbeat\tT-2\nAndrea\tT-1\nGaudenzi\tT-1\n(\tO\nItaly\tO\n)\tO\n\nBohdan\tO\nUlihrach\tO\n(\tO\nCzech\tT-1\nRepublic\tT-1\n)\tO\nbeat\tT-2\nAndrea\tB-PER\nGaudenzi\tI-PER\n(\tO\nItaly\tT-3\n)\tT-0\n\nBohdan\tO\nUlihrach\tO\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\nbeat\tT-1\nAndrea\tT-0\nGaudenzi\tT-0\n(\tO\nItaly\tB-LOC\n)\tO\n\nTim\tB-PER\nHenman\tI-PER\n(\tO\nBritain\tO\n)\tO\nbeat\tO\nChris\tO\nWoodruff\tO\n(\tO\nU.S.\tO\n)\tO\n,\tO\nwalkover\tT-0\n\nTim\tO\nHenman\tO\n(\tO\nBritain\tB-LOC\n)\tO\nbeat\tT-1\nChris\tT-0\nWoodruff\tT-0\n(\tO\nU.S.\tT-2\n)\tO\n,\tO\nwalkover\tO\n\nTim\tO\nHenman\tO\n(\tO\nBritain\tO\n)\tO\nbeat\tO\nChris\tB-PER\nWoodruff\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n,\tO\nwalkover\tO\n\nTim\tT-3\nHenman\tT-3\n(\tO\nBritain\tO\n)\tO\nbeat\tT-1\nChris\tT-2\nWoodruff\tT-2\n(\tO\nU.S.\tB-LOC\n)\tO\n,\tO\nwalkover\tT-1\n\nCRICKET\tO\n-\tO\nMILLNS\tB-PER\nSIGNS\tT-0\nFOR\tO\nBOLAND\tT-1\n.\tO\n\nCRICKET\tT-1\n-\tO\nMILLNS\tO\nSIGNS\tT-0\nFOR\tO\nBOLAND\tB-ORG\n.\tO\n\nSouth\tB-MISC\nAfrican\tI-MISC\nprovincial\tO\nside\tO\nBoland\tO\nsaid\tT-1\non\tO\nThursday\tO\nthey\tO\nhad\tO\nsigned\tT-0\nLeicestershire\tT-2\nfast\tO\nbowler\tO\nDavid\tO\nMillns\tO\non\tO\na\tO\none\tO\nyear\tO\ncontract\tO\n.\tO\n\nSouth\tO\nAfrican\tO\nprovincial\tO\nside\tO\nBoland\tB-ORG\nsaid\tT-0\non\tO\nThursday\tO\nthey\tO\nhad\tO\nsigned\tO\nLeicestershire\tO\nfast\tO\nbowler\tO\nDavid\tO\nMillns\tO\non\tO\na\tO\none\tO\nyear\tO\ncontract\tO\n.\tO\n\nSouth\tO\nAfrican\tO\nprovincial\tO\nside\tO\nBoland\tT-0\nsaid\tO\non\tO\nThursday\tO\nthey\tO\nhad\tO\nsigned\tT-1\nLeicestershire\tB-ORG\nfast\tT-2\nbowler\tT-2\nDavid\tO\nMillns\tO\non\tO\na\tO\none\tO\nyear\tO\ncontract\tO\n.\tO\n\nSouth\tO\nAfrican\tO\nprovincial\tO\nside\tO\nBoland\tO\nsaid\tO\non\tO\nThursday\tO\nthey\tT-1\nhad\tT-1\nsigned\tO\nLeicestershire\tO\nfast\tT-2\nbowler\tT-2\nDavid\tB-PER\nMillns\tI-PER\non\tO\na\tO\none\tO\nyear\tO\ncontract\tO\n.\tO\n\nMillns\tB-MISC\n,\tO\nwho\tT-1\ntoured\tT-1\nAustralia\tO\nwith\tO\nEngland\tO\nA\tO\nin\tO\n1992/93\tO\n,\tO\nreplaces\tO\nformer\tO\nEngland\tO\nall-rounder\tO\nPhillip\tO\nDeFreitas\tO\nas\tO\nBoland\tO\n's\tO\noverseas\tO\nprofessional\tO\n.\tO\n\nMillns\tT-1\n,\tO\nwho\tO\ntoured\tT-0\nAustralia\tB-LOC\nwith\tO\nEngland\tO\nA\tO\nin\tO\n1992/93\tO\n,\tO\nreplaces\tO\nformer\tO\nEngland\tO\nall-rounder\tO\nPhillip\tO\nDeFreitas\tO\nas\tO\nBoland\tO\n's\tO\noverseas\tT-2\nprofessional\tO\n.\tO\n\nMillns\tO\n,\tO\nwho\tO\ntoured\tT-1\nAustralia\tT-1\nwith\tO\nEngland\tB-LOC\nA\tO\nin\tO\n1992/93\tO\n,\tO\nreplaces\tO\nformer\tO\nEngland\tO\nall-rounder\tO\nPhillip\tO\nDeFreitas\tO\nas\tO\nBoland\tT-2\n's\tT-2\noverseas\tT-0\nprofessional\tO\n.\tO\n\nMillns\tT-2\n,\tO\nwho\tO\ntoured\tT-0\nAustralia\tO\nwith\tO\nEngland\tO\nA\tO\nin\tO\n1992/93\tO\n,\tO\nreplaces\tO\nformer\tO\nEngland\tB-LOC\nall-rounder\tO\nPhillip\tO\nDeFreitas\tO\nas\tO\nBoland\tO\n's\tO\noverseas\tT-1\nprofessional\tO\n.\tO\n\nMillns\tT-0\n,\tO\nwho\tO\ntoured\tO\nAustralia\tO\nwith\tO\nEngland\tO\nA\tO\nin\tO\n1992/93\tO\n,\tO\nreplaces\tT-1\nformer\tT-2\nEngland\tT-2\nall-rounder\tT-2\nPhillip\tB-PER\nDeFreitas\tI-PER\nas\tO\nBoland\tT-3\n's\tT-3\noverseas\tT-3\nprofessional\tT-3\n.\tT-3\n\nMillns\tT-1\n,\tO\nwho\tO\ntoured\tT-0\nAustralia\tT-2\nwith\tO\nEngland\tO\nA\tO\nin\tO\n1992/93\tO\n,\tO\nreplaces\tO\nformer\tO\nEngland\tO\nall-rounder\tO\nPhillip\tO\nDeFreitas\tO\nas\tO\nBoland\tB-ORG\n's\tO\noverseas\tO\nprofessional\tO\n.\tO\n\nSOCCER\tO\n-\tO\nEUROPEAN\tB-MISC\nCUP\tI-MISC\nWINNERS\tI-MISC\n'\tI-MISC\nCUP\tI-MISC\nRESULTS\tT-0\n.\tO\n\nResults\tT-0\nof\tO\nEuropean\tB-MISC\nCup\tI-MISC\nWinners\tI-MISC\n'\tI-MISC\n\nCup\tB-MISC\nqualifying\tO\nround\tO\n,\tO\nsecond\tO\nleg\tO\nsoccer\tT-0\nmatches\tT-1\non\tO\nThursday\tO\n:\tO\n\nIn\tO\nTirana\tB-LOC\n:\tO\nFlamurtari\tT-0\nVlore\tT-0\n(\tO\nAlbania\tO\n)\tO\n0\tT-1\nChemlon\tT-1\nHumenne\tT-1\n\nIn\tT-0\nTirana\tO\n:\tO\nFlamurtari\tB-ORG\nVlore\tI-ORG\n(\tO\nAlbania\tO\n)\tO\n0\tO\nChemlon\tO\nHumenne\tO\n\nIn\tO\nTirana\tO\n:\tO\nFlamurtari\tT-0\nVlore\tT-0\n(\tO\nAlbania\tB-LOC\n)\tO\n0\tT-2\nChemlon\tT-1\nHumenne\tT-1\n\nIn\tO\nTirana\tO\n:\tO\nFlamurtari\tT-0\nVlore\tT-0\n(\tO\nAlbania\tT-1\n)\tO\n0\tO\nChemlon\tB-ORG\nHumenne\tI-ORG\n\n(\tO\nSlovakia\tB-LOC\n)\tO\n2\tT-0\n(\tO\nhalftime\tO\n0-0\tO\n)\tO\n\nScorers\tO\n:\tO\nLubarskij\tB-PER\n(\tO\n50th\tT-0\nminute\tT-0\n)\tO\n,\tO\nValkucak\tT-1\n(\tO\n54th\tO\n)\tO\n\nScorers\tO\n:\tO\nLubarskij\tT-1\n(\tO\n50th\tO\nminute\tO\n)\tO\n,\tO\nValkucak\tB-PER\n(\tO\n54th\tT-0\n)\tO\n\nChemlon\tB-ORG\nHumenne\tI-ORG\nwin\tT-1\n3-0\tO\non\tO\naggregate\tT-0\n\nIn\tT-0\nBistrita\tB-LOC\n:\tO\nGloria\tO\nBistrita\tO\n(\tO\nRomania\tT-1\n)\tO\n2\tO\nValletta\tT-3\n(\tO\nMalta\tT-2\n)\tO\n1\tO\n\nIn\tO\nBistrita\tO\n:\tO\nGloria\tB-ORG\nBistrita\tI-ORG\n(\tO\nRomania\tO\n)\tO\n2\tO\nValletta\tO\n(\tO\nMalta\tT-0\n)\tO\n1\tO\n\nIn\tO\nBistrita\tT-1\n:\tO\nGloria\tO\nBistrita\tO\n(\tO\nRomania\tB-LOC\n)\tO\n2\tO\nValletta\tT-2\n(\tO\nMalta\tT-0\n)\tO\n1\tO\n\nIn\tT-2\nBistrita\tT-0\n:\tO\nGloria\tT-1\nBistrita\tT-1\n(\tO\nRomania\tO\n)\tO\n2\tO\nValletta\tB-LOC\n(\tO\nMalta\tO\n)\tO\n1\tO\n\nIn\tO\nBistrita\tO\n:\tO\nGloria\tT-0\nBistrita\tT-0\n(\tO\nRomania\tT-1\n)\tO\n2\tO\nValletta\tT-2\n(\tO\nMalta\tB-LOC\n)\tO\n1\tO\n\nGloria\tB-ORG\nBistrita\tI-ORG\n-\tO\nIlie\tT-0\nLazar\tT-0\n(\tO\n32nd\tO\n)\tO\n,\tO\nEugen\tT-1\nVoica\tT-1\n(\tO\n84th\tO\n)\tO\n\nGloria\tO\nBistrita\tO\n-\tO\nIlie\tB-PER\nLazar\tI-PER\n(\tO\n32nd\tO\n)\tO\n,\tO\nEugen\tT-0\nVoica\tT-0\n(\tO\n84th\tO\n)\tO\n\nGloria\tO\nBistrita\tO\n-\tO\nIlie\tO\nLazar\tO\n(\tO\n32nd\tO\n)\tO\n,\tO\nEugen\tB-PER\nVoica\tI-PER\n(\tT-0\n84th\tT-0\n)\tT-0\n\nValletta\tT-0\n-\tO\nGilbert\tB-PER\nAgius\tI-PER\n(\tO\n24th\tO\n)\tO\n\nGloria\tB-ORG\nBistrita\tI-ORG\nwin\tT-0\n4-2\tO\non\tO\naggregate\tO\n.\tO\n\nIn\tT-0\nChorzow\tO\n:\tO\nRuch\tB-ORG\nChorzow\tI-ORG\n(\tO\nPoland\tO\n)\tO\n5\tO\nLlansantffraid\tO\n(\tO\nWales\tO\n)\tO\n0\tO\n\nIn\tT-2\nChorzow\tO\n:\tO\nRuch\tT-0\nChorzow\tT-0\n(\tO\nPoland\tB-LOC\n)\tO\n5\tO\nLlansantffraid\tT-1\n(\tO\nWales\tO\n)\tO\n0\tO\n\nIn\tT-0\nChorzow\tT-0\n:\tO\nRuch\tO\nChorzow\tO\n(\tO\nPoland\tO\n)\tO\n5\tO\nLlansantffraid\tB-ORG\n(\tO\nWales\tO\n)\tO\n0\tO\n\nIn\tO\nChorzow\tO\n:\tO\nRuch\tT-0\nChorzow\tT-0\n(\tO\nPoland\tO\n)\tO\n5\tO\nLlansantffraid\tT-1\n(\tO\nWales\tB-LOC\n)\tO\n0\tO\n\nScorers\tT-1\n:\tO\nArkadiusz\tB-PER\nBak\tI-PER\n(\tO\n1st\tT-2\nand\tO\n55th\tT-3\n)\tO\n,\tO\nArwel\tO\nJones\tO\n(\tO\n47th\tT-0\n,\tO\n\nown\tO\ngoal\tO\n)\tO\n,\tO\nMiroslav\tB-PER\nBak\tI-PER\n(\tT-0\n62nd\tT-0\nand\tT-0\n63rd\tT-0\n)\tT-0\n\nIn\tT-1\nLarnaca\tB-LOC\n:\tO\nAEK\tT-0\nLarnaca\tT-0\n(\tO\nCyprus\tO\n)\tO\n5\tO\nKotaik\tO\nAbovyan\tO\n(\tO\nArmenia\tO\n)\tO\n\nIn\tO\nLarnaca\tT-0\n:\tO\nAEK\tB-ORG\nLarnaca\tI-ORG\n(\tO\nCyprus\tT-1\n)\tO\n5\tO\nKotaik\tT-2\nAbovyan\tT-2\n(\tO\nArmenia\tT-3\n)\tO\n\nIn\tO\nLarnaca\tO\n:\tO\nAEK\tO\nLarnaca\tO\n(\tO\nCyprus\tB-LOC\n)\tO\n5\tO\nKotaik\tO\nAbovyan\tT-0\n(\tO\nArmenia\tO\n)\tO\n\nIn\tO\nLarnaca\tO\n:\tO\nAEK\tT-0\nLarnaca\tT-0\n(\tO\nCyprus\tO\n)\tO\n5\tO\nKotaik\tT-1\nAbovyan\tT-1\n(\tO\nArmenia\tB-LOC\n)\tO\n\nScorers\tO\n:\tO\nZoran\tB-PER\nKundic\tI-PER\n(\tO\n28th\tT-0\n)\tO\n,\tO\nKlimis\tO\nAlexandrou\tO\n(\tO\n41st\tO\n)\tO\n,\tO\n\nScorers\tO\n:\tO\nZoran\tT-0\nKundic\tT-0\n(\tO\n28th\tO\n)\tO\n,\tO\nKlimis\tB-PER\nAlexandrou\tI-PER\n(\tO\n41st\tT-1\n)\tO\n,\tO\n\nMilenko\tB-PER\nKovasevic\tI-PER\n(\tO\n60th\tT-0\n,\tO\npenalty\tT-1\n)\tO\n,\tO\nGoran\tO\nKoprinovic\tO\n(\tO\n82nd\tO\n)\tO\n,\tO\n\nPavlos\tB-PER\nMarkou\tI-PER\n(\tO\n84th\tT-0\n)\tO\n\nAEK\tB-ORG\nLarnaca\tI-ORG\nwin\tT-0\n5-1\tO\non\tO\naggregate\tT-1\n\nIn\tO\nSiauliai\tB-LOC\n:\tO\nKareda\tT-0\nSiauliai\tT-0\n(\tO\nLithuania\tO\n)\tO\n0\tO\nSion\tO\n\nIn\tO\nSiauliai\tO\n:\tO\nKareda\tB-ORG\nSiauliai\tI-ORG\n(\tO\nLithuania\tT-0\n)\tO\n0\tO\nSion\tO\n\nIn\tO\nSiauliai\tO\n:\tO\nKareda\tT-0\nSiauliai\tT-0\n(\tO\nLithuania\tO\n)\tO\n0\tO\nSion\tB-ORG\n\nSion\tB-ORG\nwin\tT-0\n4-2\tO\non\tO\nagrregate\tO\n.\tO\n\nNyva\tB-ORG\nVinnytsya\tI-ORG\n(\tO\nUkraine\tT-0\n)\tO\n1\tT-1\nTallinna\tO\nSadam\tO\n(\tO\nEstonia\tO\n)\tO\n0\tO\n(\tO\n0-0\tO\n)\tO\n\nNyva\tT-0\nVinnytsya\tT-0\n(\tO\nUkraine\tB-LOC\n)\tO\n1\tO\nTallinna\tO\nSadam\tO\n(\tO\nEstonia\tT-1\n)\tO\n0\tO\n(\tO\n0-0\tO\n)\tO\n\nNyva\tT-1\nVinnytsya\tT-1\n(\tO\nUkraine\tO\n)\tO\n1\tO\nTallinna\tB-ORG\nSadam\tI-ORG\n(\tO\nEstonia\tT-0\n)\tT-0\n0\tT-0\n(\tT-0\n0-0\tT-0\n)\tO\n\nIn\tT-0\nBergen\tB-LOC\n:\tO\nBrann\tT-1\n(\tO\nNorway\tO\n)\tO\n2\tO\nShelbourne\tT-2\n(\tO\nIreland\tT-3\n)\tO\n1\tO\n(\tO\n1-1\tO\n)\tO\n\nIn\tO\nBergen\tT-1\n:\tO\nBrann\tB-ORG\n(\tO\nNorway\tT-0\n)\tO\n2\tO\nShelbourne\tO\n(\tO\nIreland\tT-2\n)\tO\n1\tO\n(\tO\n1-1\tO\n)\tO\n\nIn\tO\nBergen\tT-2\n:\tO\nBrann\tT-1\n(\tO\nNorway\tB-LOC\n)\tO\n2\tO\nShelbourne\tT-0\n(\tO\nIreland\tT-3\n)\tO\n1\tO\n(\tO\n1-1\tO\n)\tO\n\nIn\tT-1\nBergen\tT-2\n:\tO\nBrann\tO\n(\tO\nNorway\tO\n)\tO\n2\tO\nShelbourne\tB-ORG\n(\tO\nIreland\tT-0\n)\tO\n1\tO\n(\tO\n1-1\tO\n)\tO\n\nIn\tO\nBergen\tO\n:\tO\nBrann\tO\n(\tO\nNorway\tO\n)\tO\n2\tO\nShelbourne\tT-0\n(\tO\nIreland\tB-LOC\n)\tO\n1\tO\n(\tO\n1-1\tO\n)\tO\n\nBrann\tB-ORG\n-\tO\nMons\tT-0\nIvar\tT-0\nMjelde\tT-0\n(\tO\n10th\tO\n)\tO\n,\tO\nJan\tT-1\nOve\tT-1\nPedersen\tT-1\n(\tO\n72nd\tO\n)\tO\n\nBrann\tT-0\n-\tO\nMons\tB-PER\nIvar\tI-PER\nMjelde\tI-PER\n(\tO\n10th\tT-1\n)\tO\n,\tO\nJan\tT-2\nOve\tT-2\nPedersen\tT-2\n(\tO\n72nd\tO\n)\tO\n\nBrann\tO\n-\tO\nMons\tO\nIvar\tO\nMjelde\tO\n(\tO\n10th\tT-0\n)\tO\n,\tO\nJan\tB-PER\nOve\tI-PER\nPedersen\tI-PER\n(\tO\n72nd\tT-1\n)\tO\n\nShelbourne\tB-ORG\n-\tO\nMark\tT-1\nRutherford\tT-1\n(\tO\n5th\tO\n)\tO\n\nBrann\tB-ORG\nwin\tT-0\n5-2\tO\non\tT-1\naggregate\tT-1\n\nIn\tO\nSofia\tB-LOC\n:\tO\nLevski\tT-0\nSofia\tT-0\n(\tO\nBulgaria\tO\n)\tO\n1\tO\nOlimpija\tT-1\n(\tO\nSlovenia\tO\n)\tO\n0\tO\n\nIn\tO\nSofia\tT-0\n:\tO\nLevski\tB-ORG\nSofia\tI-ORG\n(\tO\nBulgaria\tT-1\n)\tO\n1\tO\nOlimpija\tO\n(\tO\nSlovenia\tO\n)\tO\n0\tO\n\nIn\tO\nSofia\tT-1\n:\tO\nLevski\tO\nSofia\tO\n(\tO\nBulgaria\tB-LOC\n)\tO\n1\tO\nOlimpija\tT-0\n(\tO\nSlovenia\tO\n)\tO\n0\tO\n\nIn\tO\nSofia\tO\n:\tO\nLevski\tT-0\nSofia\tT-0\n(\tO\nBulgaria\tO\n)\tO\n1\tT-1\nOlimpija\tB-ORG\n(\tO\nSlovenia\tO\n)\tO\n0\tT-2\n\nIn\tO\nSofia\tT-0\n:\tO\nLevski\tO\nSofia\tO\n(\tO\nBulgaria\tO\n)\tO\n1\tO\nOlimpija\tT-1\n(\tO\nSlovenia\tB-LOC\n)\tO\n0\tO\n\nOlimpija\tB-ORG\nwon\tO\n4-3\tO\non\tO\npenalties\tT-1\n.\tO\n\nIn\tO\nVaduz\tB-LOC\n:\tO\nVaduz\tT-0\n(\tO\nLiechtenstein\tO\n)\tO\n1\tO\nRAF\tO\nRiga\tO\n(\tO\nLatvia\tO\n)\tO\n1\tO\n(\tO\n0-0\tO\n)\tO\n\nIn\tO\nVaduz\tT-1\n:\tO\nVaduz\tB-LOC\n(\tO\nLiechtenstein\tT-0\n)\tO\n1\tO\nRAF\tT-2\nRiga\tT-2\n(\tO\nLatvia\tO\n)\tO\n1\tO\n(\tO\n0-0\tO\n)\tO\n\nIn\tT-1\nVaduz\tT-0\n:\tO\nVaduz\tT-2\n(\tO\nLiechtenstein\tB-LOC\n)\tO\n1\tO\nRAF\tO\nRiga\tO\n(\tO\nLatvia\tO\n)\tO\n1\tO\n(\tO\n0-0\tO\n)\tO\n\nIn\tO\nVaduz\tO\n:\tO\nVaduz\tO\n(\tO\nLiechtenstein\tO\n)\tO\n1\tO\nRAF\tB-ORG\nRiga\tI-ORG\n(\tO\nLatvia\tT-0\n)\tO\n1\tO\n(\tO\n0-0\tO\n)\tO\n\nIn\tO\nVaduz\tO\n:\tO\nVaduz\tT-0\n(\tO\nLiechtenstein\tT-1\n)\tO\n1\tO\nRAF\tO\nRiga\tO\n(\tO\nLatvia\tB-LOC\n)\tO\n1\tO\n(\tO\n0-0\tO\n)\tO\n\nVaduz\tB-LOC\n-\tO\nDaniele\tT-1\nPolverino\tT-1\n(\tO\n90th\tO\n)\tO\n\nVaduz\tT-0\n-\tO\nDaniele\tB-PER\nPolverino\tI-PER\n(\tO\n90th\tO\n)\tO\n\nRAF\tB-ORG\nRiga\tI-ORG\n-\tO\nAgrins\tT-0\nZarins\tO\n(\tO\n47th\tO\n)\tO\n\nRAF\tT-0\nRiga\tT-0\n-\tO\nAgrins\tB-PER\nZarins\tI-PER\n(\tO\n47th\tT-1\n)\tO\n\nVaduz\tB-LOC\nwon\tO\n4-2\tT-0\non\tT-0\npenalties\tT-0\n.\tT-0\n\nIn\tO\nLuxembourg\tB-LOC\n:\tO\nUS\tO\nLuxembourg\tO\n(\tO\nLuxembourg\tT-0\n)\tO\n0\tO\nVarteks\tT-1\nVarazdin\tT-1\n\nIn\tO\nLuxembourg\tO\n:\tO\nUS\tB-ORG\nLuxembourg\tI-ORG\n(\tO\nLuxembourg\tT-0\n)\tO\n0\tO\nVarteks\tO\nVarazdin\tO\n\nIn\tT-0\nLuxembourg\tT-2\n:\tO\nUS\tO\nLuxembourg\tT-3\n(\tO\nLuxembourg\tB-LOC\n)\tO\n0\tO\nVarteks\tT-1\nVarazdin\tT-1\n\nIn\tO\nLuxembourg\tO\n:\tO\nUS\tO\nLuxembourg\tT-0\n(\tO\nLuxembourg\tO\n)\tO\n0\tO\nVarteks\tB-ORG\nVarazdin\tI-ORG\n\n(\tO\nCroatia\tB-LOC\n)\tO\n3\tT-0\n(\tO\n0-0\tT-2\n)\tT-1\n\nScorers\tT-1\n:\tO\nDrazen\tB-PER\nBeser\tI-PER\n(\tO\n63rd\tT-2\n)\tO\n,\tO\nMiljenko\tT-0\nMumler\tT-0\n(\tO\npenalty\tO\n,\tO\n\nScorers\tT-0\n:\tO\nDrazen\tT-2\nBeser\tT-2\n(\tO\n63rd\tO\n)\tO\n,\tO\nMiljenko\tB-PER\nMumler\tI-PER\n(\tO\npenalty\tT-1\n,\tO\n\n78th\tT-0\n)\tO\n,\tO\nJamir\tB-PER\nCvetko\tI-PER\n(\tO\n87th\tO\n)\tT-1\n\nVarteks\tB-ORG\nVarazdin\tI-ORG\nwin\tT-0\n5-1\tO\non\tO\naggregate\tT-1\n.\tO\n\nIn\tO\nTorshavn\tB-LOC\n:\tO\nHavnar\tT-0\nBoltfelag\tT-0\n(\tO\nFaroe\tO\nIslands\tO\n)\tO\n0\tO\nDynamo\tO\n\nIn\tT-0\nTorshavn\tT-2\n:\tO\nHavnar\tB-ORG\nBoltfelag\tI-ORG\n(\tO\nFaroe\tO\nIslands\tT-1\n)\tO\n0\tO\nDynamo\tO\n\nIn\tO\nTorshavn\tT-0\n:\tO\nHavnar\tT-1\nBoltfelag\tT-2\n(\tO\nFaroe\tB-LOC\nIslands\tI-LOC\n)\tO\n0\tO\nDynamo\tO\n\nIn\tO\nTorshavn\tO\n:\tO\nHavnar\tT-1\nBoltfelag\tT-1\n(\tT-0\nFaroe\tT-0\nIslands\tT-0\n)\tT-0\n0\tO\nDynamo\tB-ORG\n\nBatumi\tB-ORG\n(\tO\nGeorgia\tT-0\n)\tO\n3\tO\n(\tO\n0-2\tO\n)\tO\n\nBatumi\tT-1\n(\tO\nGeorgia\tB-LOC\n)\tO\n3\tT-0\n(\tT-0\n0-2\tT-0\n)\tT-0\n\nIn\tO\nPrague\tB-LOC\n:\tO\nSparta\tO\nPrague\tT-0\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\n8\tO\nGlentoran\tO\n\nIn\tT-0\nPrague\tT-1\n:\tO\nSparta\tB-ORG\nPrague\tI-ORG\n(\tO\nCzech\tT-2\nRepublic\tT-2\n)\tO\n8\tO\nGlentoran\tO\n\nIn\tO\nPrague\tO\n:\tO\nSparta\tT-0\nPrague\tT-0\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n8\tO\nGlentoran\tO\n\nIn\tO\nPrague\tO\n:\tO\nSparta\tT-0\nPrague\tT-0\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\n8\tO\nGlentoran\tB-ORG\n\n(\tO\nNorthern\tB-LOC\nIreland\tI-LOC\n)\tO\n0\tO\n(\tO\n4-0\tT-0\n)\tO\n\nScorers\tT-0\n:\tO\nPetr\tB-PER\nGunda\tI-PER\n(\tO\n1st\tT-1\nand\tT-1\n26th\tT-1\n)\tO\n,\tO\nLumir\tO\nMistr\tO\n(\tO\n19th\tO\n)\tO\n,\tO\n\nScorers\tT-0\n:\tO\nPetr\tO\nGunda\tO\n(\tO\n1st\tO\nand\tO\n26th\tO\n)\tO\n,\tO\nLumir\tB-PER\nMistr\tI-PER\n(\tO\n19th\tO\n)\tO\n,\tO\n\nHorst\tB-PER\nSiegl\tI-PER\n(\tO\n24th\tT-1\n,\tO\n48th\tT-2\n,\tO\n80th\tT-3\n)\tO\n,\tO\nZdenek\tT-0\nSvoboda\tT-0\n(\tO\n76th\tO\n)\tO\n,\tO\nPetr\tO\n\nHorst\tT-1\nSiegl\tT-1\n(\tO\n24th\tO\n,\tO\n48th\tO\n,\tO\n80th\tO\n)\tO\n,\tO\nZdenek\tB-PER\nSvoboda\tI-PER\n(\tO\n76th\tT-0\n)\tO\n,\tO\nPetr\tO\n\nHorst\tT-0\nSiegl\tT-0\n(\tO\n24th\tO\n,\tO\n48th\tO\n,\tO\n80th\tO\n)\tO\n,\tO\nZdenek\tT-1\nSvoboda\tT-1\n(\tO\n76th\tO\n)\tO\n,\tO\nPetr\tB-PER\n\nGabriel\tB-PER\n(\tO\n86th\tT-0\n)\tO\n\nSparta\tB-ORG\nwin\tT-0\n10-1\tO\non\tO\naggregate\tT-1\n.\tO\n\nIn\tO\nEdinburgh\tB-LOC\n:\tO\nHearts\tO\n(\tT-0\nScotland\tT-0\n)\tT-0\n1\tO\nRed\tT-1\nStar\tT-1\nBelgrade\tT-1\n\nIn\tT-0\nEdinburgh\tT-1\n:\tO\nHearts\tB-ORG\n(\tO\nScotland\tO\n)\tO\n1\tO\nRed\tT-2\nStar\tT-2\nBelgrade\tT-2\n\nIn\tO\nEdinburgh\tO\n:\tO\nHearts\tO\n(\tO\nScotland\tB-LOC\n)\tO\n1\tO\nRed\tT-0\nStar\tT-0\nBelgrade\tT-0\n\nIn\tO\nEdinburgh\tT-0\n:\tO\nHearts\tO\n(\tO\nScotland\tT-1\n)\tO\n1\tO\nRed\tB-ORG\nStar\tI-ORG\nBelgrade\tI-ORG\n\nHearts\tB-ORG\n-\tO\nDave\tO\nMcPherson\tT-0\n(\tO\n44th\tO\n)\tO\n\nHearts\tO\n-\tO\nDave\tB-PER\nMcPherson\tI-PER\n(\tO\n44th\tT-0\n)\tO\n\nRed\tB-ORG\nStar\tI-ORG\n-\tO\nVinko\tT-0\nMarinovic\tT-0\n(\tO\n59th\tO\n)\tO\n\nRed\tT-0\nStar\tT-0\n-\tO\nVinko\tB-MISC\nMarinovic\tI-MISC\n(\tO\n59th\tO\n)\tO\n\nRed\tB-ORG\nStar\tI-ORG\nwin\tT-1\non\tO\naway\tT-2\ngoals\tT-0\nrule\tO\n.\tO\n\nIn\tT-1\nRishon-Lezion\tB-LOC\n:\tO\nHapoel\tT-0\nIroni\tO\n(\tO\nIsrael\tO\n)\tO\n3\tO\nConstructorul\tO\n\nIn\tO\nRishon-Lezion\tO\n:\tO\nHapoel\tB-ORG\nIroni\tI-ORG\n(\tO\nIsrael\tO\n)\tO\n3\tO\nConstructorul\tT-0\n\nIn\tO\nRishon-Lezion\tO\n:\tO\nHapoel\tT-0\nIroni\tT-0\n(\tO\nIsrael\tB-LOC\n)\tO\n3\tO\nConstructorul\tO\n\nIn\tO\nRishon-Lezion\tT-1\n:\tO\nHapoel\tT-2\nIroni\tT-2\n(\tO\nIsrael\tT-0\n)\tO\n3\tO\nConstructorul\tB-ORG\n\nChisinau\tB-ORG\n(\tO\nMoldova\tO\n)\tO\n2\tO\n(\tO\n2-1\tT-0\n)\tO\n\nChisinau\tT-0\n(\tO\nMoldova\tB-LOC\n)\tO\n2\tO\n(\tO\n2-1\tO\n)\tO\n\nConstructorul\tB-ORG\nwin\tT-1\non\tO\naway\tT-2\ngoals\tT-0\nrule\tO\n.\tO\n\nIn\tO\nAnjalonkoski\tB-MISC\n:\tO\nMyPa-47\tO\n(\tO\nFinland\tO\n)\tO\n1\tO\nKarabach\tT-0\nAgdam\tO\n\nIn\tO\nAnjalonkoski\tT-0\n:\tO\nMyPa-47\tB-ORG\n(\tO\nFinland\tT-2\n)\tO\n1\tO\nKarabach\tT-1\nAgdam\tT-1\n\nIn\tO\nAnjalonkoski\tT-0\n:\tO\nMyPa-47\tO\n(\tO\nFinland\tB-LOC\n)\tO\n1\tO\nKarabach\tT-1\nAgdam\tT-1\n\nIn\tO\nAnjalonkoski\tT-0\n:\tO\nMyPa-47\tO\n(\tO\nFinland\tO\n)\tO\n1\tO\nKarabach\tB-ORG\nAgdam\tI-ORG\n\nMypa-47\tB-ORG\nwin\tT-1\n2-1\tO\non\tO\naggregate\tT-0\n.\tO\n\nIn\tO\nSkopje\tB-LOC\n:\tO\nSloga\tO\nJugomagnat\tT-0\n(\tO\nMacedonia\tT-1\n)\tO\n0\tO\nKispest\tT-2\nHonved\tO\n\nIn\tO\nSkopje\tO\n:\tO\nSloga\tB-ORG\nJugomagnat\tI-ORG\n(\tO\nMacedonia\tT-0\n)\tO\n0\tO\nKispest\tO\nHonved\tO\n\nIn\tO\nSkopje\tT-0\n:\tO\nSloga\tO\nJugomagnat\tO\n(\tO\nMacedonia\tB-LOC\n)\tO\n0\tT-1\nKispest\tO\nHonved\tO\n\n(\tO\nHungary\tB-LOC\n1\tO\n(\tO\n0-0\tT-0\n)\tO\n\nKispest\tB-ORG\nHonved\tI-ORG\nwin\tT-0\n2-0\tO\non\tO\naggregate\tO\n.\tO\n\nAdd\tB-ORG\nHapoel\tI-ORG\nIroni\tI-ORG\nv\tO\nConstructorul\tT-0\nChisinau\tO\n\nAdd\tO\nHapoel\tT-0\nIroni\tT-0\nv\tO\nConstructorul\tB-ORG\nChisinau\tI-ORG\n\nRishon\tB-ORG\n-\tO\nMoshe\tT-0\nSabag\tT-0\n(\tO\n10th\tT-1\nminute\tT-1\n)\tO\n,\tO\nNissan\tO\nKapeta\tO\n(\tO\n26th\tO\n)\tO\n,\tO\n\nRishon\tO\n-\tO\nMoshe\tB-PER\nSabag\tI-PER\n(\tO\n10th\tT-0\nminute\tT-0\n)\tO\n,\tO\nNissan\tO\nKapeta\tO\n(\tO\n26th\tO\n)\tO\n,\tO\n\nTomas\tB-PER\nCibola\tI-PER\n(\tO\n58th\tT-0\n)\tO\n.\tO\n\nConstructorol\tB-ORG\n-\tO\nSergei\tT-0\nRogachev\tT-0\n(\tO\n42nd\tO\n)\tO\n,\tO\nGennadi\tT-1\nSkidan\tT-1\n\nConstructorol\tT-0\n-\tO\nSergei\tB-PER\nRogachev\tI-PER\n(\tO\n42nd\tT-1\n)\tO\n,\tO\nGennadi\tO\nSkidan\tO\n\nConstructorol\tO\n-\tO\nSergei\tT-0\nRogachev\tT-0\n(\tO\n42nd\tO\n)\tO\n,\tO\nGennadi\tB-PER\nSkidan\tI-PER\n\nSOCCER\tT-1\n-\tO\nGOTHENBURG\tB-LOC\nPUT\tO\nFERENCVAROS\tO\nOUT\tO\nOF\tO\nEURO\tO\nCUP\tT-0\n.\tO\n\nSOCCER\tO\n-\tO\nGOTHENBURG\tT-1\nPUT\tO\nFERENCVAROS\tB-ORG\nOUT\tT-0\nOF\tT-0\nEURO\tT-0\nCUP\tT-0\n.\tO\n\nSOCCER\tT-0\n-\tO\nGOTHENBURG\tO\nPUT\tO\nFERENCVAROS\tO\nOUT\tT-1\nOF\tT-1\nEURO\tB-MISC\nCUP\tI-MISC\n.\tO\n\nIFK\tB-ORG\nGothenburg\tI-ORG\nof\tT-2\nSweden\tT-1\ndrew\tT-0\n1-1\tO\n(\tO\n1-0\tO\n)\tO\nwith\tO\nFerencvaros\tO\nof\tO\nHungary\tO\nin\tO\nthe\tO\nsecond\tO\nleg\tO\nof\tO\ntheir\tO\nEuropean\tO\nChampions\tO\nCup\tO\npreliminary\tO\nround\tO\ntie\tO\nplayed\tO\non\tO\nWednesday\tO\n.\tO\n\nIFK\tO\nGothenburg\tT-1\nof\tO\nSweden\tB-LOC\ndrew\tT-4\n1-1\tO\n(\tO\n1-0\tO\n)\tO\nwith\tO\nFerencvaros\tT-3\nof\tO\nHungary\tT-2\nin\tO\nthe\tO\nsecond\tT-0\nleg\tO\nof\tO\ntheir\tO\nEuropean\tO\nChampions\tO\nCup\tO\npreliminary\tO\nround\tO\ntie\tO\nplayed\tO\non\tO\nWednesday\tO\n.\tO\n\nIFK\tT-0\nGothenburg\tT-0\nof\tO\nSweden\tO\ndrew\tT-1\n1-1\tO\n(\tO\n1-0\tO\n)\tO\nwith\tO\nFerencvaros\tB-ORG\nof\tT-3\nHungary\tT-3\nin\tO\nthe\tO\nsecond\tT-2\nleg\tT-2\nof\tO\ntheir\tO\nEuropean\tO\nChampions\tO\nCup\tO\npreliminary\tO\nround\tO\ntie\tO\nplayed\tO\non\tO\nWednesday\tO\n.\tO\n\nIFK\tO\nGothenburg\tO\nof\tO\nSweden\tO\ndrew\tO\n1-1\tO\n(\tO\n1-0\tO\n)\tO\nwith\tO\nFerencvaros\tT-2\nof\tT-0\nHungary\tB-LOC\nin\tO\nthe\tO\nsecond\tO\nleg\tO\nof\tT-1\ntheir\tT-1\nEuropean\tO\nChampions\tO\nCup\tO\npreliminary\tO\nround\tO\ntie\tO\nplayed\tO\non\tO\nWednesday\tO\n.\tO\n\nIFK\tO\nGothenburg\tO\nof\tO\nSweden\tT-2\ndrew\tO\n1-1\tO\n(\tO\n1-0\tO\n)\tO\nwith\tO\nFerencvaros\tO\nof\tO\nHungary\tO\nin\tO\nthe\tO\nsecond\tT-0\nleg\tT-0\nof\tT-0\ntheir\tT-0\nEuropean\tB-MISC\nChampions\tI-MISC\nCup\tI-MISC\npreliminary\tT-1\nround\tT-1\ntie\tO\nplayed\tT-3\non\tO\nWednesday\tO\n.\tO\n\nGothenburg\tB-LOC\ngo\tT-2\nthrough\tT-2\n4-1\tT-0\non\tO\naggregate\tT-1\n.\tT-1\n\nSOCCER\tO\n-\tO\nBRAZILIAN\tB-MISC\nCHAMPIONSHIP\tT-0\nRESULTS\tO\n.\tO\n\nmatches\tT-0\nin\tO\nthe\tO\nBrazilian\tB-MISC\nsoccer\tT-1\nchampionship\tT-1\n.\tO\n\nBahia\tB-ORG\n2\tT-0\nAtletico\tT-1\nParanaense\tT-1\n0\tO\n\nBahia\tT-0\n2\tO\nAtletico\tB-ORG\nParanaense\tI-ORG\n0\tO\n\nCorinthians\tB-ORG\n1\tT-0\nGuarani\tO\n0\tO\n\nCoritiba\tB-ORG\n1\tO\nAtletico\tT-0\nMineiro\tT-0\n0\tO\n\nCoritiba\tT-0\n1\tO\nAtletico\tB-ORG\nMineiro\tI-ORG\n0\tO\n\nCruzeiro\tB-ORG\n2\tT-0\nVitoria\tO\n1\tO\n\nFlamengo\tB-ORG\n0\tO\nJuventude\tT-0\n1\tO\n\nFlamengo\tO\n0\tT-0\nJuventude\tB-ORG\n1\tO\n\nGoias\tB-ORG\n3\tT-0\nSport\tO\nRecife\tT-1\n1\tO\n\nGoias\tO\n3\tO\nSport\tB-ORG\nRecife\tI-ORG\n1\tT-0\n\nGremio\tB-ORG\n6\tT-1\nBragantino\tT-0\n1\tO\n\nGremio\tT-0\n6\tO\nBragantino\tB-ORG\n1\tO\n\nPalmeiras\tB-ORG\n3\tT-0\nVasco\tO\nda\tO\nGama\tO\n1\tO\n\nPalmeiras\tT-0\n3\tO\nVasco\tB-ORG\nda\tI-ORG\nGama\tI-ORG\n1\tO\n\nPortuguesa\tB-ORG\n2\tT-1\nParana\tT-0\n0\tO\n\nTENNIS\tT-2\n-\tO\nNEWCOMBE\tB-PER\nPONDERS\tO\nHIS\tT-0\nDAVIS\tO\nCUP\tO\nFUTURE\tT-1\n.\tO\n\nTENNIS\tO\n-\tO\nNEWCOMBE\tT-0\nPONDERS\tT-1\nHIS\tT-2\nDAVIS\tB-MISC\nCUP\tI-MISC\nFUTURE\tO\n.\tO\n\nAustralian\tB-MISC\nDavis\tO\nCup\tO\ncaptain\tT-0\nJohn\tO\nNewcombe\tO\non\tO\nThursday\tO\nsignalled\tO\nhis\tO\npossible\tO\nresignation\tO\nif\tO\nhis\tO\nteam\tO\nloses\tO\nan\tO\naway\tO\ntie\tO\nagainst\tO\nCroatia\tO\nnext\tO\nmonth\tO\n.\tO\n\nAustralian\tO\nDavis\tB-MISC\nCup\tI-MISC\ncaptain\tO\nJohn\tO\nNewcombe\tT-0\non\tO\nThursday\tO\nsignalled\tT-1\nhis\tO\npossible\tO\nresignation\tO\nif\tO\nhis\tO\nteam\tT-2\nloses\tO\nan\tO\naway\tO\ntie\tO\nagainst\tO\nCroatia\tO\nnext\tO\nmonth\tO\n.\tT-0\n\nAustralian\tT-1\nDavis\tO\nCup\tO\ncaptain\tT-2\nJohn\tB-PER\nNewcombe\tI-PER\non\tO\nThursday\tO\nsignalled\tO\nhis\tO\npossible\tO\nresignation\tO\nif\tO\nhis\tO\nteam\tO\nloses\tO\nan\tO\naway\tO\ntie\tO\nagainst\tO\nCroatia\tT-0\nnext\tO\nmonth\tO\n.\tO\n\nAustralian\tT-0\nDavis\tO\nCup\tO\ncaptain\tT-1\nJohn\tT-3\nNewcombe\tT-3\non\tO\nThursday\tO\nsignalled\tT-2\nhis\tO\npossible\tO\nresignation\tO\nif\tO\nhis\tO\nteam\tO\nloses\tO\nan\tO\naway\tO\ntie\tO\nagainst\tO\nCroatia\tB-LOC\nnext\tO\nmonth\tO\n.\tO\n\nThe\tO\nformer\tO\nWimbledon\tB-MISC\nchampion\tT-3\nsaid\tO\nthe\tO\nimmediate\tO\nfuture\tO\nof\tO\nAustralia\tT-0\n's\tO\nDavis\tT-1\nCup\tT-1\ncoach\tO\nTony\tT-2\nRoche\tT-2\ncould\tO\nalso\tO\nbe\tO\ndetermined\tO\nby\tO\nevents\tO\nin\tO\nSplit\tO\n.\tO\n\nThe\tO\nformer\tO\nWimbledon\tO\nchampion\tO\nsaid\tO\nthe\tO\nimmediate\tO\nfuture\tT-1\nof\tO\nAustralia\tB-LOC\n's\tO\nDavis\tT-0\nCup\tT-0\ncoach\tO\nTony\tO\nRoche\tO\ncould\tO\nalso\tO\nbe\tO\ndetermined\tO\nby\tO\nevents\tO\nin\tO\nSplit\tO\n.\tO\n\nThe\tO\nformer\tO\nWimbledon\tT-0\nchampion\tT-1\nsaid\tO\nthe\tO\nimmediate\tO\nfuture\tT-2\nof\tO\nAustralia\tO\n's\tO\nDavis\tB-MISC\nCup\tI-MISC\ncoach\tO\nTony\tO\nRoche\tO\ncould\tO\nalso\tO\nbe\tO\ndetermined\tO\nby\tO\nevents\tT-3\nin\tO\nSplit\tO\n.\tO\n\nThe\tO\nformer\tO\nWimbledon\tT-1\nchampion\tT-1\nsaid\tT-2\nthe\tO\nimmediate\tO\nfuture\tO\nof\tO\nAustralia\tO\n's\tO\nDavis\tT-0\nCup\tT-0\ncoach\tT-0\nTony\tB-PER\nRoche\tI-PER\ncould\tO\nalso\tO\nbe\tO\ndetermined\tT-3\nby\tO\nevents\tO\nin\tO\nSplit\tO\n.\tO\n\nThe\tO\nformer\tO\nWimbledon\tO\nchampion\tO\nsaid\tT-0\nthe\tO\nimmediate\tO\nfuture\tO\nof\tO\nAustralia\tO\n's\tO\nDavis\tO\nCup\tO\ncoach\tO\nTony\tO\nRoche\tO\ncould\tO\nalso\tO\nbe\tO\ndetermined\tT-1\nby\tO\nevents\tT-2\nin\tO\nSplit\tB-LOC\n.\tO\n\n\"\tO\nIf\tO\nwe\tO\nlose\tO\nthis\tO\none\tT-2\n,\tO\nTony\tB-PER\nand\tT-3\nI\tT-3\nwill\tO\nhave\tO\nto\tO\nhave\tO\na\tO\ngood\tO\nlook\tO\nat\tO\ngiving\tT-0\nsomeone\tO\nelse\tO\na\tO\ngo\tO\n,\tO\n\"\tO\nNewcombe\tO\nwas\tO\nquoted\tO\nas\tO\nsaying\tO\nin\tO\nSydney\tO\n's\tO\nDaily\tT-1\nTelegraph\tT-1\nnewspaper\tO\n.\tO\n\n\"\tO\nIf\tO\nwe\tO\nlose\tO\nthis\tO\none\tO\n,\tO\nTony\tO\nand\tO\nI\tO\nwill\tO\nhave\tO\nto\tO\nhave\tO\na\tO\ngood\tO\nlook\tO\nat\tO\ngiving\tO\nsomeone\tO\nelse\tO\na\tO\ngo\tO\n,\tO\n\"\tO\nNewcombe\tB-PER\nwas\tO\nquoted\tO\nas\tO\nsaying\tT-0\nin\tO\nSydney\tO\n's\tO\nDaily\tO\nTelegraph\tO\nnewspaper\tO\n.\tO\n\n\"\tO\nIf\tO\nwe\tO\nlose\tO\nthis\tO\none\tO\n,\tO\nTony\tT-1\nand\tO\nI\tO\nwill\tO\nhave\tO\nto\tO\nhave\tO\na\tO\ngood\tO\nlook\tO\nat\tO\ngiving\tO\nsomeone\tO\nelse\tO\na\tO\ngo\tO\n,\tO\n\"\tO\nNewcombe\tT-0\nwas\tO\nquoted\tO\nas\tO\nsaying\tT-2\nin\tT-2\nSydney\tB-LOC\n's\tO\nDaily\tO\nTelegraph\tO\nnewspaper\tO\n.\tO\n\n\"\tO\nIf\tO\nwe\tO\nlose\tO\nthis\tO\none\tO\n,\tO\nTony\tO\nand\tO\nI\tO\nwill\tO\nhave\tO\nto\tO\nhave\tO\na\tO\ngood\tO\nlook\tO\nat\tO\ngiving\tO\nsomeone\tO\nelse\tO\na\tO\ngo\tO\n,\tO\n\"\tO\nNewcombe\tT-0\nwas\tO\nquoted\tO\nas\tO\nsaying\tO\nin\tO\nSydney\tT-1\n's\tT-1\nDaily\tB-ORG\nTelegraph\tI-ORG\nnewspaper\tO\n.\tO\n\nAustralia\tB-LOC\nface\tO\nCroatia\tT-0\nin\tO\nthe\tO\nworld\tO\ngroup\tO\nqualifying\tO\ntie\tO\non\tO\nclay\tO\nfrom\tO\nSeptember\tO\n20-22\tO\n.\tO\n\nAustralia\tO\nface\tO\nCroatia\tB-LOC\nin\tO\nthe\tO\nworld\tT-0\ngroup\tO\nqualifying\tO\ntie\tO\non\tO\nclay\tO\nfrom\tO\nSeptember\tO\n20-22\tO\n.\tO\n\nUnder\tO\nNewcombe\tB-PER\n's\tO\nleadership\tT-1\n,\tO\nAustralia\tT-2\nwere\tO\nrelegated\tT-0\nfrom\tO\nthe\tO\nelite\tO\nworld\tO\ngroup\tO\nlast\tO\nyear\tO\n,\tO\nthe\tO\nfirst\tO\ntime\tO\nthe\tO\n26-time\tT-4\nDavis\tT-3\nCup\tT-3\nwinners\tT-3\nhad\tO\nslipped\tO\nfrom\tO\nthe\tO\ntop\tO\nrank\tO\n.\tO\n\nUnder\tO\nNewcombe\tO\n's\tO\nleadership\tT-0\n,\tO\nAustralia\tB-LOC\nwere\tT-1\nrelegated\tT-1\nfrom\tO\nthe\tO\nelite\tO\nworld\tO\ngroup\tO\nlast\tO\nyear\tO\n,\tO\nthe\tO\nfirst\tO\ntime\tO\nthe\tO\n26-time\tO\nDavis\tO\nCup\tO\nwinners\tO\nhad\tO\nslipped\tO\nfrom\tO\nthe\tO\ntop\tO\nrank\tO\n.\tO\n\nUnder\tO\nNewcombe\tT-3\n's\tO\nleadership\tT-4\n,\tO\nAustralia\tT-5\nwere\tO\nrelegated\tO\nfrom\tO\nthe\tO\nelite\tO\nworld\tO\ngroup\tO\nlast\tO\nyear\tO\n,\tO\nthe\tO\nfirst\tT-0\ntime\tO\nthe\tO\n26-time\tT-1\nDavis\tB-MISC\nCup\tI-MISC\nwinners\tT-2\nhad\tO\nslipped\tO\nfrom\tO\nthe\tO\ntop\tO\nrank\tO\n.\tO\n\nSince\tO\ntaking\tO\nover\tO\nas\tO\ncaptain\tT-1\nfrom\tO\nNeale\tB-PER\nFraser\tI-PER\nin\tO\n1994\tO\n,\tO\nNewcombe\tT-2\n's\tT-2\nrecord\tO\nin\tO\ntandem\tO\nwith\tO\nRoche\tT-3\n,\tO\nhis\tO\nformer\tO\ndoubles\tT-0\npartner\tT-0\n,\tO\nhas\tO\nbeen\tO\nthree\tO\nwins\tO\nand\tO\nthree\tO\nlosses\tO\n.\tO\n\nSince\tO\ntaking\tT-5\nover\tO\nas\tO\ncaptain\tT-1\nfrom\tO\nNeale\tT-2\nFraser\tT-2\nin\tO\n1994\tO\n,\tO\nNewcombe\tB-PER\n's\tO\nrecord\tT-0\nin\tO\ntandem\tO\nwith\tO\nRoche\tO\n,\tO\nhis\tO\nformer\tO\ndoubles\tO\npartner\tO\n,\tO\nhas\tO\nbeen\tO\nthree\tT-3\nwins\tT-3\nand\tO\nthree\tT-4\nlosses\tT-4\n.\tO\n\nSince\tO\ntaking\tO\nover\tO\nas\tO\ncaptain\tT-0\nfrom\tO\nNeale\tO\nFraser\tO\nin\tO\n1994\tO\n,\tO\nNewcombe\tO\n's\tO\nrecord\tT-2\nin\tT-2\ntandem\tO\nwith\tO\nRoche\tB-PER\n,\tO\nhis\tO\nformer\tO\ndoubles\tO\npartner\tT-1\n,\tO\nhas\tO\nbeen\tO\nthree\tO\nwins\tO\nand\tO\nthree\tO\nlosses\tO\n.\tO\n\nNewcombe\tB-PER\nhas\tO\nselected\tO\nWimbledon\tT-0\nsemifinalist\tT-1\nJason\tO\nStoltenberg\tO\n,\tO\nPatrick\tO\nRafter\tO\n,\tO\nMark\tO\nPhilippoussis\tO\n,\tO\nand\tO\nOlympic\tO\ndoubles\tO\nchampions\tO\nTodd\tO\nWoodbridge\tO\nand\tO\nMark\tO\nWoodforde\tO\nto\tO\nface\tO\nthe\tO\nCroatians\tO\n.\tO\n\nNewcombe\tO\nhas\tO\nselected\tO\nWimbledon\tB-MISC\nsemifinalist\tT-0\nJason\tO\nStoltenberg\tO\n,\tO\nPatrick\tO\nRafter\tO\n,\tO\nMark\tO\nPhilippoussis\tO\n,\tO\nand\tO\nOlympic\tO\ndoubles\tO\nchampions\tO\nTodd\tO\nWoodbridge\tO\nand\tO\nMark\tO\nWoodforde\tO\nto\tO\nface\tO\nthe\tO\nCroatians\tO\n.\tO\n\nNewcombe\tO\nhas\tO\nselected\tO\nWimbledon\tT-0\nsemifinalist\tO\nJason\tT-2\nStoltenberg\tT-2\n,\tO\nPatrick\tB-PER\nRafter\tI-PER\n,\tO\nMark\tO\nPhilippoussis\tO\n,\tO\nand\tO\nOlympic\tO\ndoubles\tO\nchampions\tT-1\nTodd\tO\nWoodbridge\tO\nand\tO\nMark\tO\nWoodforde\tO\nto\tO\nface\tO\nthe\tO\nCroatians\tO\n.\tO\n\nNewcombe\tT-0\nhas\tO\nselected\tO\nWimbledon\tO\nsemifinalist\tO\nJason\tO\nStoltenberg\tO\n,\tO\nPatrick\tO\nRafter\tO\n,\tO\nMark\tB-PER\nPhilippoussis\tI-PER\n,\tO\nand\tO\nOlympic\tO\ndoubles\tO\nchampions\tO\nTodd\tO\nWoodbridge\tO\nand\tO\nMark\tO\nWoodforde\tO\nto\tO\nface\tO\nthe\tO\nCroatians\tO\n.\tO\n\nNewcombe\tT-2\nhas\tT-0\nselected\tT-0\nWimbledon\tT-1\nsemifinalist\tO\nJason\tO\nStoltenberg\tO\n,\tO\nPatrick\tO\nRafter\tO\n,\tO\nMark\tO\nPhilippoussis\tO\n,\tO\nand\tO\nOlympic\tB-MISC\ndoubles\tO\nchampions\tO\nTodd\tO\nWoodbridge\tO\nand\tO\nMark\tO\nWoodforde\tO\nto\tO\nface\tO\nthe\tO\nCroatians\tO\n.\tO\n\nNewcombe\tO\nhas\tO\nselected\tO\nWimbledon\tO\nsemifinalist\tO\nJason\tO\nStoltenberg\tO\n,\tO\nPatrick\tO\nRafter\tO\n,\tO\nMark\tO\nPhilippoussis\tO\n,\tO\nand\tO\nOlympic\tT-1\ndoubles\tO\nchampions\tT-0\nTodd\tB-PER\nWoodbridge\tI-PER\nand\tO\nMark\tO\nWoodforde\tO\nto\tO\nface\tO\nthe\tO\nCroatians\tO\n.\tT-1\n\nNewcombe\tO\nhas\tO\nselected\tO\nWimbledon\tO\nsemifinalist\tO\nJason\tO\nStoltenberg\tO\n,\tO\nPatrick\tO\nRafter\tO\n,\tO\nMark\tO\nPhilippoussis\tO\n,\tO\nand\tO\nOlympic\tT-0\ndoubles\tO\nchampions\tO\nTodd\tT-1\nWoodbridge\tT-1\nand\tO\nMark\tB-PER\nWoodforde\tI-PER\nto\tO\nface\tO\nthe\tO\nCroatians\tO\n.\tT-0\n\nNewcombe\tO\nhas\tO\nselected\tO\nWimbledon\tO\nsemifinalist\tO\nJason\tO\nStoltenberg\tO\n,\tO\nPatrick\tO\nRafter\tO\n,\tO\nMark\tO\nPhilippoussis\tO\n,\tO\nand\tO\nOlympic\tT-1\ndoubles\tO\nchampions\tO\nTodd\tO\nWoodbridge\tO\nand\tO\nMark\tO\nWoodforde\tO\nto\tO\nface\tT-0\nthe\tO\nCroatians\tB-MISC\n.\tO\n\nThe\tO\nhome\tO\nside\tO\nboasts\tT-0\nworld\tT-1\nnumber\tT-1\nsix\tT-1\nGoran\tB-PER\nIvanisevic\tI-PER\n,\tO\nand\tO\nNewcombe\tO\nconceded\tO\nhis\tO\nplayers\tO\nwould\tO\nbe\tO\nhard-pressed\tO\nto\tO\nbeat\tO\nthe\tO\nCroatian\tO\nnumber\tO\none\tO\n.\tO\n\nThe\tO\nhome\tO\nside\tO\nboasts\tT-1\nworld\tO\nnumber\tO\nsix\tO\nGoran\tO\nIvanisevic\tO\n,\tO\nand\tO\nNewcombe\tB-PER\nconceded\tO\nhis\tO\nplayers\tT-0\nwould\tO\nbe\tO\nhard-pressed\tO\nto\tO\nbeat\tT-2\nthe\tT-2\nCroatian\tT-2\nnumber\tT-2\none\tT-2\n.\tO\n\nThe\tO\nhome\tO\nside\tO\nboasts\tO\nworld\tO\nnumber\tO\nsix\tO\nGoran\tO\nIvanisevic\tO\n,\tO\nand\tO\nNewcombe\tT-1\nconceded\tT-2\nhis\tO\nplayers\tT-0\nwould\tO\nbe\tO\nhard-pressed\tO\nto\tO\nbeat\tT-3\nthe\tO\nCroatian\tB-MISC\nnumber\tO\none\tO\n.\tO\n\n\"\tO\nWe\tT-1\nare\tT-1\nready\tT-1\nto\tT-1\nfight\tT-1\nto\tT-1\nour\tT-1\nlast\tT-1\nbreath\tT-1\n--\tO\nAustralia\tB-LOC\nmust\tO\nplay\tO\nat\tO\nits\tO\nabsolute\tO\nbest\tO\nto\tO\nwin\tO\n,\tO\n\"\tO\nsaid\tO\nNewcombe\tO\n,\tO\nwho\tO\ndescribed\tO\nthe\tO\ntie\tO\nas\tO\nthe\tO\ntoughest\tO\nhe\tO\nhas\tO\nfaced\tO\nas\tO\ncaptain\tO\n.\tO\n\n\"\tO\nWe\tO\nare\tO\nready\tO\nto\tO\nfight\tT-4\nto\tO\nour\tO\nlast\tT-5\nbreath\tT-5\n--\tO\nAustralia\tT-3\nmust\tO\nplay\tO\nat\tO\nits\tO\nabsolute\tO\nbest\tO\nto\tO\nwin\tT-6\n,\tO\n\"\tO\nsaid\tT-1\nNewcombe\tB-PER\n,\tO\nwho\tO\ndescribed\tT-2\nthe\tO\ntie\tO\nas\tO\nthe\tO\ntoughest\tO\nhe\tO\nhas\tO\nfaced\tO\nas\tO\ncaptain\tO\n.\tO\n\nAustralia\tB-LOC\nlast\tO\nwon\tT-1\nthe\tO\nDavis\tO\nCup\tT-0\nin\tO\n1986\tO\n,\tO\nbut\tO\nthey\tO\nwere\tO\nbeaten\tT-2\nfinalists\tO\nagainst\tO\nGermany\tT-4\nthree\tO\nyears\tO\nago\tO\nunder\tO\nFraser\tT-5\n's\tO\nguidance\tT-3\n.\tO\n\nAustralia\tT-2\nlast\tO\nwon\tT-0\nthe\tO\nDavis\tB-MISC\nCup\tI-MISC\nin\tO\n1986\tO\n,\tO\nbut\tO\nthey\tO\nwere\tO\nbeaten\tO\nfinalists\tT-1\nagainst\tO\nGermany\tO\nthree\tO\nyears\tO\nago\tO\nunder\tO\nFraser\tO\n's\tO\nguidance\tO\n.\tO\n\nAustralia\tO\nlast\tO\nwon\tT-0\nthe\tO\nDavis\tO\nCup\tO\nin\tO\n1986\tO\n,\tO\nbut\tO\nthey\tO\nwere\tO\nbeaten\tT-1\nfinalists\tO\nagainst\tO\nGermany\tB-LOC\nthree\tO\nyears\tO\nago\tO\nunder\tO\nFraser\tO\n's\tO\nguidance\tO\n.\tO\n\nAustralia\tT-0\nlast\tT-3\nwon\tT-3\nthe\tO\nDavis\tT-1\nCup\tT-2\nin\tO\n1986\tO\n,\tO\nbut\tO\nthey\tO\nwere\tO\nbeaten\tO\nfinalists\tO\nagainst\tO\nGermany\tO\nthree\tO\nyears\tO\nago\tO\nunder\tO\nFraser\tB-PER\n's\tO\nguidance\tO\n.\tO\n\nBADMINTON\tT-0\n-\tO\nMALAYSIAN\tB-MISC\nOPEN\tI-MISC\nRESULTS\tO\n.\tO\n\nResults\tT-0\nin\tT-0\nthe\tT-0\nMalaysian\tB-MISC\n\nOpen\tB-MISC\nbadminton\tT-0\ntournament\tT-2\non\tO\nThursday\tT-1\n(\tO\nprefix\tO\nnumber\tO\ndenotes\tO\n\n9/16\tO\n-\tO\nLuo\tB-PER\nYigang\tI-PER\n(\tO\nChina\tT-0\n)\tO\nbeat\tT-2\nHwang\tO\nSun-ho\tO\n(\tO\nSouth\tT-1\nKorea\tT-1\n)\tO\n15-3\tO\n\n9/16\tO\n-\tO\nLuo\tT-0\nYigang\tT-0\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nHwang\tO\nSun-ho\tO\n(\tO\nSouth\tT-1\nKorea\tT-1\n)\tO\n15-3\tO\n\n9/16\tO\n-\tO\nLuo\tT-1\nYigang\tT-1\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\nHwang\tB-PER\nSun-ho\tO\n(\tO\nSouth\tO\nKorea\tO\n)\tO\n15-3\tO\n\n9/16\tO\n-\tO\nLuo\tT-0\nYigang\tT-0\n(\tO\nChina\tO\n)\tO\nbeat\tT-2\nHwang\tT-1\nSun-ho\tB-MISC\n(\tO\nSouth\tT-3\nKorea\tT-3\n)\tO\n15-3\tO\n\n9/16\tO\n-\tO\nLuo\tO\nYigang\tO\n(\tO\nChina\tO\n)\tO\nbeat\tT-1\nHwang\tT-0\nSun-ho\tT-0\n(\tO\nSouth\tB-LOC\nKorea\tI-LOC\n)\tO\n15-3\tO\n\nJason\tB-PER\nWong\tI-PER\n(\tO\nMalaysia\tO\n)\tO\nbeat\tT-1\nAbdul\tT-0\nSamad\tT-0\nIsmail\tT-0\n(\tO\nMalaysia\tO\n)\tO\n16-18\tO\n\nJason\tO\nWong\tO\n(\tO\nMalaysia\tB-LOC\n)\tO\nbeat\tT-1\nAbdul\tO\nSamad\tO\nIsmail\tO\n(\tT-0\nMalaysia\tT-0\n)\tT-0\n16-18\tO\n\nJason\tT-0\nWong\tT-0\n(\tO\nMalaysia\tT-1\n)\tO\nbeat\tT-3\nAbdul\tB-PER\nSamad\tI-PER\nIsmail\tI-PER\n(\tO\nMalaysia\tT-2\n)\tO\n16-18\tO\n\nJason\tO\nWong\tO\n(\tO\nMalaysia\tO\n)\tO\nbeat\tO\nAbdul\tT-0\nSamad\tT-0\nIsmail\tT-0\n(\tO\nMalaysia\tB-LOC\n)\tO\n16-18\tO\n\nP.\tB-PER\nKantharoopan\tI-PER\n(\tO\nMalaysia\tO\n)\tO\nbeat\tO\n3/4\tO\n-\tO\nJeroen\tT-0\nVan\tT-0\nDijk\tT-0\n\nP.\tO\nKantharoopan\tO\n(\tO\nMalaysia\tB-LOC\n)\tO\nbeat\tT-0\n3/4\tO\n-\tO\nJeroen\tT-1\nVan\tT-1\nDijk\tT-1\n\nP.\tT-1\nKantharoopan\tT-1\n(\tO\nMalaysia\tT-0\n)\tO\nbeat\tO\n3/4\tO\n-\tO\nJeroen\tB-PER\nVan\tI-PER\nDijk\tI-PER\n\n(\tO\nNetherlands\tB-LOC\n)\tO\n15-11\tT-0\n18-14\tT-1\n\nWijaya\tB-PER\nIndra\tI-PER\n(\tO\nIndonesia\tT-0\n)\tO\nbeat\tT-1\n5/8\tO\n-\tO\nPang\tO\nChen\tO\n(\tO\nMalaysia\tO\n)\tO\n15-6\tO\n\nWijaya\tT-0\nIndra\tT-0\n(\tO\nIndonesia\tB-LOC\n)\tO\nbeat\tO\n5/8\tO\n-\tO\nPang\tO\nChen\tO\n(\tO\nMalaysia\tT-1\n)\tO\n15-6\tO\n\nWijaya\tO\nIndra\tO\n(\tO\nIndonesia\tO\n)\tO\nbeat\tT-0\n5/8\tO\n-\tO\nPang\tB-PER\nChen\tI-PER\n(\tO\nMalaysia\tO\n)\tO\n15-6\tO\n\nWijaya\tT-2\nIndra\tT-2\n(\tO\nIndonesia\tO\n)\tO\nbeat\tT-0\n5/8\tO\n-\tO\nPang\tT-1\nChen\tT-1\n(\tO\nMalaysia\tB-LOC\n)\tO\n15-6\tO\n\n3/4\tO\n-\tO\nHu\tB-PER\nZhilan\tI-PER\n(\tO\nChina\tT-2\n)\tO\nbeat\tT-0\nNunung\tO\nSubandoro\tT-1\n(\tO\nIndonesia\tO\n)\tO\n5-15\tO\n\n3/4\tO\n-\tO\nHu\tO\nZhilan\tO\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nNunung\tT-0\nSubandoro\tT-0\n(\tO\nIndonesia\tO\n)\tO\n5-15\tO\n\n3/4\tO\n-\tO\nHu\tT-1\nZhilan\tT-1\n(\tO\nChina\tO\n)\tO\nbeat\tO\nNunung\tB-PER\nSubandoro\tI-PER\n(\tO\nIndonesia\tT-0\n)\tO\n5-15\tO\n\n3/4\tO\n-\tO\nHu\tO\nZhilan\tO\n(\tO\nChina\tO\n)\tO\nbeat\tT-1\nNunung\tT-0\nSubandoro\tT-0\n(\tO\nIndonesia\tB-LOC\n)\tO\n5-15\tO\n\n9/16\tO\n-\tO\nHermawan\tB-PER\nSusanto\tI-PER\n(\tO\nIndonesia\tT-1\n)\tO\nbeat\tT-0\n1\tO\n-\tO\nFung\tO\nPermadi\tO\n(\tO\nTaiwan\tO\n)\tO\n\n9/16\tO\n-\tO\nHermawan\tO\nSusanto\tO\n(\tO\nIndonesia\tB-LOC\n)\tO\nbeat\tT-0\n1\tO\n-\tO\nFung\tO\nPermadi\tO\n(\tO\nTaiwan\tO\n)\tO\n\n9/16\tO\n-\tO\nHermawan\tO\nSusanto\tO\n(\tO\nIndonesia\tO\n)\tO\nbeat\tT-0\n1\tO\n-\tO\nFung\tB-PER\nPermadi\tI-PER\n(\tO\nTaiwan\tO\n)\tO\n\n9/16\tO\n-\tO\nHermawan\tT-0\nSusanto\tT-0\n(\tO\nIndonesia\tT-1\n)\tO\nbeat\tT-2\n1\tO\n-\tO\nFung\tO\nPermadi\tO\n(\tO\nTaiwan\tB-LOC\n)\tO\n\n1\tO\n-\tO\nWang\tB-PER\nChen\tI-PER\n(\tO\nChina\tT-0\n)\tO\nbeat\tT-1\nCindana\tT-2\n(\tO\nIndonesia\tO\n)\tO\n11-3\tO\n1ama\tO\n(\tO\nJapan\tO\n)\tO\nbeat\tO\nMargit\tO\nBorg\tO\n(\tO\nSweden\tO\n)\tO\n11-6\tO\n11-6\tO\n\n1\tO\n-\tO\nWang\tO\nChen\tO\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tT-0\nCindana\tO\n(\tO\nIndonesia\tO\n)\tO\n11-3\tO\n1ama\tO\n(\tO\nJapan\tO\n)\tO\nbeat\tO\nMargit\tO\nBorg\tO\n(\tO\nSweden\tO\n)\tO\n11-6\tO\n11-6\tO\n\n1\tO\n-\tO\nWang\tO\nChen\tO\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\nCindana\tT-0\n(\tO\nIndonesia\tB-LOC\n)\tO\n11-3\tO\n1ama\tO\n(\tO\nJapan\tO\n)\tO\nbeat\tO\nMargit\tO\nBorg\tO\n(\tO\nSweden\tO\n)\tO\n11-6\tO\n11-6\tO\n\n1\tO\n-\tO\nWang\tO\nChen\tO\n(\tO\nChina\tO\n)\tO\nbeat\tT-1\nCindana\tO\n(\tO\nIndonesia\tO\n)\tO\n11-3\tO\n1ama\tB-PER\n(\tO\nJapan\tT-0\n)\tO\nbeat\tT-2\nMargit\tO\nBorg\tO\n(\tO\nSweden\tO\n)\tO\n11-6\tO\n11-6\tO\n\n1\tO\n-\tO\nWang\tT-0\nChen\tT-0\n(\tO\nChina\tO\n)\tO\nbeat\tT-4\nCindana\tT-1\n(\tO\nIndonesia\tO\n)\tO\n11-3\tO\n1ama\tT-3\n(\tO\nJapan\tB-LOC\n)\tO\nbeat\tT-5\nMargit\tT-2\nBorg\tT-2\n(\tO\nSweden\tO\n)\tO\n11-6\tO\n11-6\tO\n\n1\tO\n-\tO\nWang\tO\nChen\tO\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\nCindana\tO\n(\tO\nIndonesia\tO\n)\tO\n11-3\tO\n1ama\tO\n(\tO\nJapan\tO\n)\tO\nbeat\tT-1\nMargit\tB-PER\nBorg\tI-PER\n(\tO\nSweden\tO\n)\tO\n11-6\tO\n11-6\tO\n\n1\tO\n-\tO\nWang\tT-2\nChen\tT-2\n(\tO\nChina\tO\n)\tO\nbeat\tO\nCindana\tT-3\n(\tO\nIndonesia\tO\n)\tO\n11-3\tO\n1ama\tT-4\n(\tO\nJapan\tT-0\n)\tO\nbeat\tT-1\nMargit\tT-5\nBorg\tT-5\n(\tO\nSweden\tB-LOC\n)\tO\n11-6\tO\n11-6\tO\n\nSun\tB-PER\nJian\tI-PER\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\nMarina\tT-1\nAndrievskaqya\tT-1\n(\tO\nSweden\tO\n)\tO\n11-8\tO\n11-2\tO\n\nSun\tT-1\nJian\tT-1\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tT-0\nMarina\tO\nAndrievskaqya\tO\n(\tO\nSweden\tO\n)\tO\n11-8\tO\n11-2\tO\n\nSun\tO\nJian\tO\n(\tO\nChina\tO\n)\tO\nbeat\tT-1\nMarina\tB-PER\nAndrievskaqya\tI-PER\n(\tO\nSweden\tT-0\n)\tO\n11-8\tO\n11-2\tO\n\nSun\tT-1\nJian\tT-1\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\nMarina\tT-2\nAndrievskaqya\tT-2\n(\tO\nSweden\tB-LOC\n)\tO\n11-8\tO\n11-2\tO\n\n5/8\tO\n-\tO\nMeluawati\tB-PER\n(\tO\nIndonesia\tO\n)\tO\nbeat\tO\nChan\tT-0\nChia\tT-0\nFong\tT-0\n(\tO\nMalaysia\tO\n)\tO\n11-6\tO\n\n5/8\tO\n-\tO\nMeluawati\tO\n(\tO\nIndonesia\tB-LOC\n)\tO\nbeat\tO\nChan\tO\nChia\tO\nFong\tO\n(\tO\nMalaysia\tT-0\n)\tO\n11-6\tO\n\n5/8\tO\n-\tO\nMeluawati\tT-1\n(\tO\nIndonesia\tO\n)\tO\nbeat\tT-0\nChan\tB-PER\nChia\tI-PER\nFong\tI-PER\n(\tO\nMalaysia\tO\n)\tO\n11-6\tO\n\n5/8\tO\n-\tO\nMeluawati\tT-0\n(\tO\nIndonesia\tO\n)\tO\nbeat\tO\nChan\tO\nChia\tO\nFong\tO\n(\tO\nMalaysia\tB-LOC\n)\tO\n11-6\tO\n\nGong\tB-PER\nZhichao\tI-PER\n(\tO\nChina\tT-0\n)\tO\nbeat\tO\nLiu\tO\nLufung\tO\n(\tO\nChina\tO\n)\tO\n6-11\tO\n11-7\tO\n11-3\tO\n\nGong\tO\nZhichao\tO\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tT-0\nLiu\tT-1\nLufung\tT-2\n(\tO\nChina\tO\n)\tO\n6-11\tO\n11-7\tO\n11-3\tO\n\nGong\tT-1\nZhichao\tT-1\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\nLiu\tB-PER\nLufung\tI-PER\n(\tO\nChina\tO\n)\tO\n6-11\tO\n11-7\tO\n11-3\tO\n\nGong\tT-0\nZhichao\tT-0\n(\tO\nChina\tT-1\n)\tO\nbeat\tT-2\nLiu\tO\nLufung\tT-3\n(\tO\nChina\tB-LOC\n)\tO\n6-11\tO\n11-7\tO\n11-3\tO\n\nZeng\tB-PER\nYaqiong\tI-PER\n(\tO\nChina\tO\n)\tO\nbeat\tT-1\nLi\tO\nFeng\tT-0\n(\tO\nNew\tO\nZealand\tO\n)\tO\n11-9\tO\n11-6\tO\n\nZeng\tT-0\nYaqiong\tT-0\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tO\nLi\tO\nFeng\tO\n(\tO\nNew\tT-1\nZealand\tT-1\n)\tO\n11-9\tO\n11-6\tO\n\nZeng\tO\nYaqiong\tO\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\nLi\tB-PER\nFeng\tI-PER\n(\tO\nNew\tO\nZealand\tO\n)\tO\n11-9\tO\n11-6\tO\n\nZeng\tT-0\nYaqiong\tO\n(\tO\nChina\tO\n)\tO\nbeat\tO\nLi\tT-1\nFeng\tT-1\n(\tO\nNew\tB-LOC\nZealand\tI-LOC\n)\tO\n11-9\tO\n11-6\tO\n\n5/8\tO\n-\tO\nChristine\tB-PER\nMagnusson\tI-PER\n(\tO\nSweden\tT-1\n)\tO\nbeat\tO\nIshwari\tT-0\nBoopathy\tT-0\n\n5/8\tO\n-\tO\nChristine\tT-0\nMagnusson\tT-0\n(\tO\nSweden\tB-LOC\n)\tO\nbeat\tT-2\nIshwari\tT-1\nBoopathy\tT-1\n\n5/8\tO\n-\tO\nChristine\tT-0\nMagnusson\tT-0\n(\tO\nSweden\tO\n)\tO\nbeat\tT-1\nIshwari\tB-PER\nBoopathy\tI-PER\n\n2\tO\n-\tO\nZhang\tB-PER\nNing\tI-PER\n(\tO\nChina\tO\n)\tO\nbeat\tO\nOlivia\tT-0\n(\tO\nIndonesia\tO\n)\tO\n11-8\tO\n11-6\tO\n\n2\tO\n-\tO\nZhang\tO\nNing\tO\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tT-1\nOlivia\tT-0\n(\tO\nIndonesia\tO\n)\tO\n11-8\tO\n11-6\tO\n\n2\tO\n-\tO\nZhang\tT-1\nNing\tT-1\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\nOlivia\tB-PER\n(\tO\nIndonesia\tO\n)\tO\n11-8\tO\n11-6\tO\n\n2\tO\n-\tO\nZhang\tT-0\nNing\tT-0\n(\tO\nChina\tO\n)\tO\nbeat\tT-1\nOlivia\tO\n(\tO\nIndonesia\tB-LOC\n)\tO\n11-8\tO\n11-6\tO\n\nTENNIS\tO\n-\tO\nREVISED\tT-0\nMEN\tO\n'S\tO\nDRAW\tO\nFOR\tO\nU.S.\tB-MISC\nOPEN\tI-MISC\n.\tO\n\nU.S.\tB-MISC\nOpen\tI-MISC\ntennis\tO\nchampionships\tT-0\nbeginning\tO\nMonday\tO\nat\tO\nthe\tO\nU.S\tT-1\n.\tT-1\n\nU.S.\tO\nOpen\tO\ntennis\tO\nchampionships\tT-1\nbeginning\tT-0\nMonday\tO\nat\tT-2\nthe\tT-2\nU.S\tB-LOC\n.\tO\n\nNational\tB-LOC\nTennis\tI-LOC\nCentre\tI-LOC\n(\tO\nprefix\tO\ndenotes\tO\nseeding\tT-0\n)\tO\n:\tO\n\n1\tO\n-\tO\nPete\tB-PER\nSampras\tI-PER\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-0\nAdrian\tT-1\nVoinea\tT-1\n(\tO\nRomania\tO\n)\tT-0\n\n1\tO\n-\tO\nPete\tT-2\nSampras\tT-2\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tT-0\nAdrian\tO\nVoinea\tO\n(\tO\nRomania\tT-1\n)\tO\n\n1\tO\n-\tO\nPete\tT-0\nSampras\tT-0\n(\tO\nU.S.\tO\n)\tO\nvs.\tO\nAdrian\tB-PER\nVoinea\tI-PER\n(\tO\nRomania\tT-1\n)\tO\n\n1\tO\n-\tO\nPete\tT-1\nSampras\tT-1\n(\tT-1\nU.S.\tT-1\n)\tT-1\nvs.\tT-0\nAdrian\tT-2\nVoinea\tT-2\n(\tO\nRomania\tB-LOC\n)\tT-0\n\nJiri\tB-PER\nNovak\tI-PER\n(\tO\nCzech\tT-1\nRepublic\tT-1\n)\tO\nvs.\tO\nqualifier\tT-0\n\nJiri\tO\nNovak\tO\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nvs.\tT-1\nqualifier\tT-1\n\nMagnus\tB-PER\nLarsson\tI-PER\n(\tO\nSweden\tO\n)\tO\nvs.\tO\nAlexander\tT-1\nVolkov\tT-1\n(\tO\nRussia\tT-0\n)\tO\n\nMagnus\tO\nLarsson\tO\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tO\nAlexander\tO\nVolkov\tO\n(\tO\nRussia\tT-0\n)\tO\n\nMagnus\tT-2\nLarsson\tT-2\n(\tO\nSweden\tO\n)\tO\nvs.\tT-0\nAlexander\tB-PER\nVolkov\tI-PER\n(\tO\nRussia\tT-1\n)\tT-0\n\nMagnus\tT-0\nLarsson\tT-0\n(\tO\nSweden\tO\n)\tO\nvs.\tO\nAlexander\tT-1\nVolkov\tT-1\n(\tO\nRussia\tB-LOC\n)\tO\n\nMikael\tB-PER\nTillstrom\tI-PER\n(\tO\nSweden\tT-0\n)\tO\nvs\tT-2\nqualifier\tT-1\n\nMikael\tT-0\nTillstrom\tT-0\n(\tO\nSweden\tB-LOC\n)\tO\nvs\tO\nqualifier\tO\n\nQualifier\tT-0\nvs.\tO\nAndrei\tB-PER\nOlhovskiy\tI-PER\n(\tO\nRussia\tT-1\n)\tO\n\nQualifier\tT-0\nvs.\tO\nAndrei\tT-1\nOlhovskiy\tT-1\n(\tO\nRussia\tB-LOC\n)\tO\n\nMark\tB-PER\nWoodforde\tI-PER\n(\tO\nAustralia\tT-0\n)\tO\nvs.\tT-1\nMark\tO\nPhilippoussis\tO\n(\tO\nAustralia\tO\n)\tO\n\nMark\tO\nWoodforde\tO\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nMark\tO\nPhilippoussis\tO\n(\tO\nAustralia\tT-0\n)\tO\n\nMark\tT-0\nWoodforde\tT-0\n(\tO\nAustralia\tO\n)\tO\nvs.\tO\nMark\tB-PER\nPhilippoussis\tI-PER\n(\tO\nAustralia\tO\n)\tO\n\nMark\tO\nWoodforde\tO\n(\tO\nAustralia\tO\n)\tO\nvs.\tO\nMark\tT-0\nPhilippoussis\tT-0\n(\tO\nAustralia\tB-LOC\n)\tO\n\nRoberto\tB-PER\nCarretero\tI-PER\n(\tO\nSpain\tO\n)\tO\nvs.\tT-0\nJordi\tO\nBurillo\tO\n(\tO\nSpain\tO\n)\tO\n\nRoberto\tT-0\nCarretero\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tT-1\nJordi\tO\nBurillo\tO\n(\tO\nSpain\tO\n)\tT-1\n\nRoberto\tO\nCarretero\tO\n(\tO\nSpain\tO\n)\tO\nvs.\tO\nJordi\tT-0\nBurillo\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n\nFrancisco\tB-PER\nClavet\tI-PER\n(\tO\nSpain\tT-0\n)\tO\nvs.\tO\n16\tO\n-\tO\nCedric\tT-2\nPioline\tT-2\n(\tO\nFrance\tT-1\n)\tO\n\nFrancisco\tT-0\nClavet\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tT-2\n16\tO\n-\tT-1\nCedric\tT-1\nPioline\tT-1\n(\tO\nFrance\tO\n)\tT-2\n\nFrancisco\tO\nClavet\tO\n(\tO\nSpain\tO\n)\tO\nvs.\tT-0\n16\tO\n-\tO\nCedric\tB-PER\nPioline\tI-PER\n(\tO\nFrance\tT-1\n)\tO\n\nFrancisco\tT-0\nClavet\tT-0\n(\tO\nSpain\tT-1\n)\tO\nvs.\tT-2\n16\tO\n-\tO\nCedric\tO\nPioline\tO\n(\tO\nFrance\tB-LOC\n)\tO\n\n9\tO\n-\tO\nWayne\tB-PER\nFerreira\tI-PER\n(\tO\nSouth\tT-0\nAfrica\tT-0\n)\tO\nvs.\tO\nqualifier\tO\n\n9\tT-2\n-\tO\nWayne\tT-0\nFerreira\tT-0\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\nvs.\tT-1\nqualifier\tT-1\n\nKarol\tB-PER\nKucera\tI-PER\n(\tT-0\nSlovakia\tT-0\n)\tT-0\nvs.\tO\nJonas\tO\nBjorkman\tO\n(\tO\nSweden\tO\n)\tO\n\nKarol\tO\nKucera\tO\n(\tO\nSlovakia\tB-LOC\n)\tO\nvs.\tT-0\nJonas\tO\nBjorkman\tO\n(\tO\nSweden\tT-1\n)\tO\n\nKarol\tT-0\nKucera\tT-0\n(\tO\nSlovakia\tO\n)\tO\nvs.\tO\nJonas\tB-PER\nBjorkman\tI-PER\n(\tO\nSweden\tT-1\n)\tO\n\nKarol\tT-0\nKucera\tT-0\n(\tO\nSlovakia\tT-1\n)\tO\nvs.\tO\nJonas\tO\nBjorkman\tO\n(\tO\nSweden\tB-LOC\n)\tO\n\nQualifier\tT-0\nvs.\tO\nChristian\tB-PER\nRudd\tI-PER\n(\tO\nNorway\tO\n)\tO\n\nQualifier\tT-0\nvs.\tO\nChristian\tT-1\nRudd\tT-1\n(\tO\nNorway\tB-LOC\n)\tO\n\nAlex\tB-PER\nCorretja\tI-PER\n(\tO\nSpain\tO\n)\tO\nvs.\tT-0\nByron\tT-1\nBlack\tT-1\n(\tO\nZimbabwe\tO\n)\tT-0\n\nAlex\tO\nCorretja\tO\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tO\nByron\tT-0\nBlack\tT-0\n(\tO\nZimbabwe\tO\n)\tO\n\nAlex\tT-1\nCorretja\tT-1\n(\tO\nSpain\tO\n)\tO\nvs.\tO\nByron\tB-PER\nBlack\tI-PER\n(\tT-2\nZimbabwe\tT-2\n)\tT-2\n\nDavid\tB-PER\nRikl\tI-PER\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\nvs.\tT-0\nHicham\tO\nArazi\tO\n(\tO\nMorocco\tO\n)\tO\n\nDavid\tT-0\nRikl\tT-0\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nvs.\tO\nHicham\tO\nArazi\tO\n(\tO\nMorocco\tO\n)\tO\n\nDavid\tT-0\nRikl\tT-0\n(\tO\nCzech\tT-1\nRepublic\tT-1\n)\tO\nvs.\tO\nHicham\tB-PER\nArazi\tI-PER\n(\tO\nMorocco\tO\n)\tO\n\nDavid\tO\nRikl\tO\n(\tO\nCzech\tT-2\nRepublic\tT-2\n)\tO\nvs.\tT-0\nHicham\tT-1\nArazi\tT-1\n(\tO\nMorocco\tB-LOC\n)\tO\n\nSjeng\tB-PER\nSchalken\tI-PER\n(\tO\nNetherlands\tT-0\n)\tO\nvs.\tO\nGilbert\tT-1\nSchaller\tT-1\n(\tO\nAustria\tO\n)\tO\n\nSjeng\tT-0\nSchalken\tT-0\n(\tO\nNetherlands\tB-LOC\n)\tO\nvs.\tO\nGilbert\tO\nSchaller\tO\n(\tO\nAustria\tT-1\n)\tO\n\nSjeng\tT-0\nSchalken\tT-0\n(\tO\nNetherlands\tO\n)\tO\nvs.\tO\nGilbert\tB-PER\nSchaller\tI-PER\n(\tO\nAustria\tO\n)\tO\n\nSjeng\tT-1\nSchalken\tT-1\n(\tO\nNetherlands\tO\n)\tO\nvs.\tT-0\nGilbert\tO\nSchaller\tO\n(\tO\nAustria\tB-LOC\n)\tO\n\nGrant\tB-PER\nStafford\tI-PER\n(\tO\nSouth\tO\nAfrica\tO\n)\tO\nvs.\tT-0\nGuy\tT-2\nForget\tT-2\n(\tO\nFrance\tT-1\n)\tO\n\nGrant\tT-2\nStafford\tT-2\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\nvs.\tT-0\nGuy\tT-1\nForget\tT-1\n(\tT-1\nFrance\tT-1\n)\tT-1\n\nGrant\tT-0\nStafford\tT-0\n(\tO\nSouth\tO\nAfrica\tO\n)\tO\nvs.\tT-1\nGuy\tB-PER\nForget\tI-PER\n(\tO\nFrance\tT-2\n)\tO\n\nGrant\tT-0\nStafford\tT-0\n(\tO\nSouth\tO\nAfrica\tO\n)\tO\nvs.\tO\nGuy\tO\nForget\tO\n(\tO\nFrance\tB-LOC\n)\tO\n\nFernando\tB-PER\nMeligeni\tI-PER\n(\tO\nBrazil\tT-1\n)\tO\nvs.\tT-3\n7\tO\n-\tO\nYevgeny\tT-0\nKafelnikov\tO\n(\tO\nRussia\tT-2\n)\tO\n\nFernando\tT-0\nMeligeni\tT-2\n(\tO\nBrazil\tB-LOC\n)\tO\nvs.\tO\n7\tO\n-\tO\nYevgeny\tT-1\nKafelnikov\tT-1\n(\tO\nRussia\tO\n)\tO\n\nFernando\tT-0\nMeligeni\tT-0\n(\tO\nBrazil\tO\n)\tO\nvs.\tO\n7\tO\n-\tO\nYevgeny\tB-PER\nKafelnikov\tI-PER\n(\tO\nRussia\tT-1\n)\tO\n\nFernando\tT-1\nMeligeni\tT-1\n(\tO\nBrazil\tT-0\n)\tO\nvs.\tO\n7\tO\n-\tO\nYevgeny\tO\nKafelnikov\tO\n(\tO\nRussia\tB-LOC\n)\tO\n\n4\tO\n-\tO\nGoran\tB-PER\nIvanisevic\tI-PER\n(\tO\nCroatia\tT-2\n)\tO\nvs.\tO\nAndrei\tT-1\nChesnokov\tT-1\n(\tO\nRussia\tT-0\n)\tO\n\n4\tO\n-\tO\nGoran\tT-0\nIvanisevic\tT-0\n(\tO\nCroatia\tB-LOC\n)\tO\nvs.\tT-1\nAndrei\tO\nChesnokov\tO\n(\tO\nRussia\tO\n)\tO\n\n4\tO\n-\tO\nGoran\tT-0\nIvanisevic\tT-0\n(\tO\nCroatia\tO\n)\tO\nvs.\tO\nAndrei\tB-PER\nChesnokov\tI-PER\n(\tO\nRussia\tO\n)\tO\n\n4\tO\n-\tO\nGoran\tT-1\nIvanisevic\tT-1\n(\tO\nCroatia\tO\n)\tO\nvs.\tT-0\nAndrei\tT-2\nChesnokov\tT-2\n(\tO\nRussia\tB-LOC\n)\tO\n\nScott\tB-PER\nDraper\tI-PER\n(\tO\nAustralia\tO\n)\tO\nvs.\tO\nGalo\tO\nBlanco\tO\n(\tO\nSpain\tT-0\n)\tO\n\nScott\tT-0\nDraper\tT-0\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nGalo\tO\nBlanco\tO\n(\tO\nSpain\tO\n)\tO\n\nScott\tT-3\nDraper\tT-3\n(\tO\nAustralia\tT-1\n)\tO\nvs.\tT-0\nGalo\tB-PER\nBlanco\tI-PER\n(\tO\nSpain\tT-2\n)\tT-0\n\nScott\tT-1\nDraper\tT-1\n(\tO\nAustralia\tO\n)\tO\nvs.\tT-0\nGalo\tO\nBlanco\tO\n(\tO\nSpain\tB-LOC\n)\tO\n\nRenzo\tB-PER\nFurlan\tI-PER\n(\tO\nItaly\tT-0\n)\tO\nvs.\tO\nThomas\tT-1\nJohansson\tT-1\n(\tO\nSweden\tO\n)\tO\n\nRenzo\tT-0\nFurlan\tT-0\n(\tO\nItaly\tB-LOC\n)\tO\nvs.\tO\nThomas\tT-1\nJohansson\tT-1\n(\tO\nSweden\tT-2\n)\tO\n\nRenzo\tT-1\nFurlan\tT-1\n(\tO\nItaly\tO\n)\tO\nvs.\tT-0\nThomas\tB-PER\nJohansson\tI-PER\n(\tO\nSweden\tO\n)\tO\n\nRenzo\tO\nFurlan\tO\n(\tO\nItaly\tO\n)\tO\nvs.\tT-0\nThomas\tO\nJohansson\tO\n(\tO\nSweden\tB-LOC\n)\tO\n\nHendrik\tB-PER\nDreekman\tI-PER\n(\tO\nGermany\tT-0\n)\tO\nvs.\tT-1\nGreg\tT-1\nRusedski\tO\n(\tO\nBritain\tO\n)\tO\n\nHendrik\tT-1\nDreekman\tT-1\n(\tO\nGermany\tB-LOC\n)\tO\nvs.\tO\nGreg\tO\nRusedski\tO\n(\tO\nBritain\tT-0\n)\tO\n\nHendrik\tO\nDreekman\tT-0\n(\tO\nGermany\tO\n)\tO\nvs.\tT-1\nGreg\tB-PER\nRusedski\tI-PER\n(\tO\nBritain\tO\n)\tO\n\nHendrik\tO\nDreekman\tO\n(\tO\nGermany\tO\n)\tO\nvs.\tT-0\nGreg\tO\nRusedski\tO\n(\tO\nBritain\tB-LOC\n)\tO\n\nAndrei\tB-PER\nMedvedev\tI-PER\n(\tO\nUkraine\tT-0\n)\tO\nvs.\tO\nJean-Philippe\tT-1\nFleurian\tT-1\n(\tO\nFrance\tO\n)\tO\n\nAndrei\tT-1\nMedvedev\tT-1\n(\tO\nUkraine\tO\n)\tO\nvs.\tT-2\nJean-Philippe\tB-PER\nFleurian\tI-PER\n(\tO\nFrance\tT-0\n)\tT-2\n\nAndrei\tO\nMedvedev\tO\n(\tO\nUkraine\tT-1\n)\tO\nvs.\tO\nJean-Philippe\tT-0\nFleurian\tT-0\n(\tO\nFrance\tB-LOC\n)\tO\n\nJan\tB-PER\nKroslak\tI-PER\n(\tO\nSlovakia\tO\n)\tO\nvs.\tT-0\nChris\tT-1\nWoodruff\tT-1\n(\tO\nU.S.\tO\n)\tT-0\n\nJan\tT-0\nKroslak\tT-0\n(\tO\nSlovakia\tB-LOC\n)\tO\nvs.\tO\nChris\tO\nWoodruff\tO\n(\tO\nU.S.\tT-1\n)\tO\n\nJan\tT-1\nKroslak\tT-1\n(\tO\nSlovakia\tO\n)\tO\nvs.\tT-0\nChris\tB-PER\nWoodruff\tI-PER\n(\tO\nU.S.\tO\n)\tO\n\nJan\tT-0\nKroslak\tT-0\n(\tO\nSlovakia\tO\n)\tO\nvs.\tO\nChris\tT-1\nWoodruff\tT-1\n(\tO\nU.S.\tB-LOC\n)\tO\n\nQualifier\tT-1\nvs.\tT-0\nPetr\tB-PER\nKorda\tI-PER\n(\tO\nCzech\tO\nRepublic\tO\n)\tT-0\n\nQualifier\tT-0\nvs.\tT-1\nPetr\tO\nKorda\tO\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n\nBohdan\tB-PER\nUlihrach\tI-PER\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\nvs.\tO\n14\tO\n-\tO\nAlberto\tT-0\nCosta\tT-0\n\nBohdan\tO\nUlihrach\tO\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nvs.\tO\n14\tO\n-\tO\nAlberto\tT-0\nCosta\tT-0\n\n12\tO\n-\tO\nTodd\tB-PER\nMartin\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\nvs.\tO\nYounnes\tT-1\nEl\tT-1\nAynaoui\tT-1\n(\tO\nMorocco\tO\n)\tO\n\n12\tO\n-\tO\nTodd\tO\nMartin\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nYounnes\tT-1\nEl\tT-1\nAynaoui\tT-1\n(\tO\nMorocco\tT-0\n)\tO\n\n12\tO\n-\tO\nTodd\tT-1\nMartin\tT-1\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-2\nYounnes\tB-PER\nEl\tI-PER\nAynaoui\tI-PER\n(\tO\nMorocco\tT-0\n)\tT-2\n\n12\tO\n-\tO\nTodd\tO\nMartin\tO\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-1\nYounnes\tT-2\nEl\tT-2\nAynaoui\tT-0\n(\tO\nMorocco\tB-LOC\n)\tO\n\nAndrea\tB-PER\nGaudenzi\tI-PER\n(\tO\nItaly\tT-1\n)\tO\nvs.\tO\nShuzo\tO\nMatsuoka\tT-0\n(\tO\nJapan\tO\n)\tO\n\nAndrea\tO\nGaudenzi\tO\n(\tO\nItaly\tB-LOC\n)\tO\nvs.\tO\nShuzo\tT-0\nMatsuoka\tT-0\n(\tO\nJapan\tO\n)\tO\n\nAndrea\tT-0\nGaudenzi\tT-0\n(\tT-0\nItaly\tT-0\n)\tT-0\nvs.\tT-0\nShuzo\tB-PER\nMatsuoka\tI-PER\n(\tO\nJapan\tO\n)\tO\n\nAndrea\tO\nGaudenzi\tO\n(\tO\nItaly\tO\n)\tO\nvs.\tO\nShuzo\tT-0\nMatsuoka\tT-0\n(\tO\nJapan\tB-LOC\n)\tO\n\nDoug\tB-PER\nFlach\tI-PER\n(\tO\nU.S.\tT-2\n)\tO\nvs.\tT-0\nqualifier\tT-2\n\nDoug\tO\nFlach\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tT-0\nqualifier\tT-0\n\nMats\tB-PER\nWilander\tI-PER\n(\tO\nSweden\tO\n)\tO\nvs.\tT-2\nTim\tT-0\nHenman\tT-0\n(\tO\nBritain\tT-1\n)\tO\n\nMats\tO\nWilander\tO\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tO\nTim\tT-0\nHenman\tT-0\n(\tO\nBritain\tT-1\n)\tO\n\nMats\tO\nWilander\tT-2\n(\tO\nSweden\tT-0\n)\tO\nvs.\tT-3\nTim\tB-PER\nHenman\tI-PER\n(\tO\nBritain\tT-1\n)\tO\n\nMats\tO\nWilander\tO\n(\tO\nSweden\tO\n)\tO\nvs.\tO\nTim\tT-0\nHenman\tT-0\n(\tO\nBritain\tB-LOC\n)\tO\n\nPaul\tB-PER\nHaarhuis\tI-PER\n(\tO\nNetherlands\tT-0\n)\tO\nvs.\tT-1\nMichael\tO\nJoyce\tO\n(\tO\nU.S.\tO\n)\tT-1\n\nPaul\tT-0\nHaarhuis\tT-0\n(\tO\nNetherlands\tB-LOC\n)\tO\nvs.\tT-1\nMichael\tO\nJoyce\tO\n(\tO\nU.S.\tO\n)\tO\n\nPaul\tT-0\nHaarhuis\tT-0\n(\tO\nNetherlands\tO\n)\tO\nvs.\tT-1\nMichael\tB-PER\nJoyce\tI-PER\n(\tO\nU.S.\tO\n)\tT-1\n\nPaul\tT-0\nHaarhuis\tT-0\n(\tO\nNetherlands\tO\n)\tO\nvs.\tT-1\nMichael\tT-2\nJoyce\tT-2\n(\tO\nU.S.\tB-LOC\n)\tO\n\nMichael\tB-PER\nTebbutt\tI-PER\n(\tO\nAustralia\tO\n)\tO\nvs.\tT-1\nRichey\tT-0\nReneberg\tT-0\n(\tO\nU.S.\tO\n)\tO\n\nMichael\tO\nTebbutt\tO\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nRichey\tT-0\nReneberg\tT-0\n(\tO\nU.S.\tO\n)\tO\n\nMichael\tT-0\nTebbutt\tT-0\n(\tO\nAustralia\tO\n)\tO\nvs.\tT-1\nRichey\tB-PER\nReneberg\tI-PER\n(\tO\nU.S.\tO\n)\tO\n\nMichael\tT-0\nTebbutt\tT-0\n(\tO\nAustralia\tT-2\n)\tO\nvs.\tO\nRichey\tT-1\nReneberg\tT-1\n(\tO\nU.S.\tB-LOC\n)\tO\n\nJonathan\tB-PER\nStark\tI-PER\n(\tO\nU.S.\tO\n)\tO\nvs.\tO\nBernd\tT-0\nKarbacher\tT-0\n(\tO\nGermany\tO\n)\tO\n\nJonathan\tO\nStark\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tT-0\nBernd\tO\nKarbacher\tO\n(\tO\nGermany\tO\n)\tO\n\nJonathan\tO\nStark\tO\n(\tO\nU.S.\tT-0\n)\tO\nvs.\tO\nBernd\tB-PER\nKarbacher\tI-PER\n(\tO\nGermany\tT-1\n)\tO\n\nStefan\tB-PER\nEdberg\tI-PER\n(\tO\nSweden\tT-2\n)\tO\nvs.\tT-1\n5\tO\n-\tO\nRichard\tT-0\nKrajicek\tT-0\n(\tO\nNetherlands\tT-3\n)\tT-1\n\nStefan\tT-1\nEdberg\tO\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tT-2\n5\tO\n-\tO\nRichard\tT-0\nKrajicek\tT-0\n(\tO\nNetherlands\tO\n)\tO\n\nStefan\tT-0\nEdberg\tT-0\n(\tO\nSweden\tO\n)\tO\nvs.\tO\n5\tO\n-\tO\nRichard\tB-PER\nKrajicek\tI-PER\n(\tO\nNetherlands\tT-1\n)\tO\n\nStefan\tO\nEdberg\tO\n(\tO\nSweden\tT-1\n)\tO\nvs.\tT-0\n5\tO\n-\tO\nRichard\tO\nKrajicek\tO\n(\tO\nNetherlands\tB-LOC\n)\tT-0\n\n6\tO\n-\tO\nAndre\tB-PER\nAgassi\tI-PER\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-1\nMauricio\tT-0\nHadad\tT-0\n(\tO\nColombia\tO\n)\tO\n\n6\tO\n-\tO\nAndre\tO\nAgassi\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tT-1\nMauricio\tT-0\nHadad\tO\n(\tO\nColombia\tT-2\n)\tO\n\n6\tO\n-\tO\nAndre\tT-2\nAgassi\tT-2\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-1\nMauricio\tB-PER\nHadad\tI-PER\n(\tO\nColombia\tT-0\n)\tT-1\n\nMarcos\tB-PER\nOndruska\tI-PER\n(\tO\nSouth\tO\nAfrica\tO\n)\tO\nvs.\tT-0\nFelix\tT-1\nMantilla\tT-1\n(\tO\nSpain\tO\n)\tT-0\n\nMarcos\tO\nOndruska\tO\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\nvs.\tT-1\nFelix\tT-0\nMantilla\tT-0\n(\tT-0\nSpain\tO\n)\tT-1\n\nMarcos\tT-0\nOndruska\tT-0\n(\tT-0\nSouth\tT-0\nAfrica\tT-0\n)\tT-0\nvs.\tT-2\nFelix\tB-PER\nMantilla\tI-PER\n(\tO\nSpain\tT-1\n)\tT-2\n\nMarcos\tO\nOndruska\tO\n(\tO\nSouth\tT-0\nAfrica\tT-0\n)\tO\nvs.\tT-1\nFelix\tT-2\nMantilla\tT-2\n(\tO\nSpain\tB-LOC\n)\tT-1\n\nCarlos\tO\nMoya\tO\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tO\nScott\tT-0\nHumphries\tT-0\n(\tO\nU.S.\tT-1\n)\tO\n\nCarlos\tT-0\nMoya\tT-0\n(\tO\nSpain\tO\n)\tO\nvs.\tT-1\nScott\tB-PER\nHumphries\tI-PER\n(\tO\nU.S.\tO\n)\tO\n\nCarlos\tO\nMoya\tO\n(\tO\nSpain\tT-0\n)\tO\nvs.\tT-1\nScott\tO\nHumphries\tO\n(\tO\nU.S.\tB-LOC\n)\tT-1\n\nJan\tB-PER\nSiemerink\tI-PER\n(\tO\nNetherlands\tO\n)\tO\nvs.\tT-2\nCarl-Uwe\tT-0\nSteeb\tT-0\n(\tO\nGermany\tT-1\n)\tT-2\n\nJan\tT-0\nSiemerink\tT-0\n(\tO\nNetherlands\tB-LOC\n)\tO\nvs.\tO\nCarl-Uwe\tO\nSteeb\tO\n(\tO\nGermany\tT-1\n)\tO\n\nJan\tO\nSiemerink\tO\n(\tO\nNetherlands\tT-0\n)\tO\nvs.\tT-2\nCarl-Uwe\tB-PER\nSteeb\tI-PER\n(\tO\nGermany\tT-1\n)\tO\n\nJan\tO\nSiemerink\tO\n(\tO\nNetherlands\tT-0\n)\tO\nvs.\tT-1\nCarl-Uwe\tO\nSteeb\tO\n(\tO\nGermany\tB-LOC\n)\tO\n\nDavid\tB-PER\nWheaton\tI-PER\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-0\nKevin\tT-1\nKim\tT-1\n(\tO\nU.S.\tO\n)\tO\n\nDavid\tT-1\nWheaton\tT-1\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nKevin\tO\nKim\tO\n(\tO\nU.S.\tT-0\n)\tO\n\nDavid\tT-0\nWheaton\tT-0\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-1\nKevin\tB-PER\nKim\tI-PER\n(\tO\nU.S.\tO\n)\tT-1\n\nDavid\tO\nWheaton\tO\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-2\nKevin\tT-0\nKim\tT-1\n(\tO\nU.S.\tB-LOC\n)\tO\n\nNicolas\tB-PER\nLapentti\tI-PER\n(\tO\nEcuador\tO\n)\tO\nvs.\tO\nAlex\tT-0\nO'Brien\tT-0\n(\tO\nU.S.\tO\n)\tO\n\nNicolas\tT-0\nLapentti\tT-0\n(\tO\nEcuador\tB-LOC\n)\tO\nvs.\tT-1\nAlex\tO\nO'Brien\tO\n(\tO\nU.S.\tO\n)\tT-1\n\nNicolas\tO\nLapentti\tO\n(\tO\nEcuador\tO\n)\tO\nvs.\tT-0\nAlex\tO\nO'Brien\tO\n(\tO\nU.S.\tB-LOC\n)\tT-0\n\nKarim\tB-PER\nAlami\tI-PER\n(\tO\nMorocco\tO\n)\tO\nvs.\tO\n11\tO\n-\tO\nMaliVai\tT-0\nWashington\tT-0\n(\tO\nU.S.\tO\n)\tO\n\nKarim\tO\nAlami\tO\n(\tO\nMorocco\tB-LOC\n)\tO\nvs.\tT-0\n11\tO\n-\tO\nMaliVai\tO\nWashington\tO\n(\tO\nU.S.\tO\n)\tO\n\nKarim\tT-0\nAlami\tT-0\n(\tO\nMorocco\tO\n)\tO\nvs.\tO\n11\tO\n-\tO\nMaliVai\tB-PER\nWashington\tI-PER\n(\tO\nU.S.\tO\n)\tO\n\nKarim\tO\nAlami\tO\n(\tO\nMorocco\tO\n)\tO\nvs.\tT-1\n11\tO\n-\tO\nMaliVai\tT-2\nWashington\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n\n13\tO\n-\tO\nThomas\tB-PER\nEnqvist\tI-PER\n(\tO\nSweden\tO\n)\tO\nvs.\tT-0\nStephane\tT-1\nSimian\tT-1\n(\tO\nFrance\tO\n)\tT-0\n\n13\tO\n-\tO\nThomas\tT-0\nEnqvist\tT-0\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tO\nStephane\tO\nSimian\tO\n(\tO\nFrance\tT-1\n)\tO\n\n13\tO\n-\tO\nThomas\tO\nEnqvist\tO\n(\tO\nSweden\tT-1\n)\tO\nvs.\tT-0\nStephane\tB-PER\nSimian\tI-PER\n(\tO\nFrance\tO\n)\tO\n\n13\tO\n-\tO\nThomas\tT-1\nEnqvist\tT-1\n(\tO\nSweden\tO\n)\tO\nvs.\tO\nStephane\tT-0\nSimian\tT-0\n(\tO\nFrance\tB-LOC\n)\tO\n\nGuillaume\tB-PER\nRaoux\tI-PER\n(\tO\nFrance\tO\n)\tO\nvs.\tO\nFilip\tT-1\nDewulf\tT-1\n(\tO\nBelgium\tT-0\n)\tO\n\nGuillaume\tT-2\nRaoux\tT-3\n(\tO\nFrance\tB-LOC\n)\tO\nvs.\tO\nFilip\tT-0\nDewulf\tT-0\n(\tO\nBelgium\tT-1\n)\tO\n\nGuillaume\tT-1\nRaoux\tT-1\n(\tO\nFrance\tO\n)\tO\nvs.\tT-0\nFilip\tB-PER\nDewulf\tI-PER\n(\tO\nBelgium\tO\n)\tT-0\n\nGuillaume\tT-0\nRaoux\tT-0\n(\tO\nFrance\tO\n)\tO\nvs.\tO\nFilip\tT-1\nDewulf\tT-1\n(\tO\nBelgium\tB-LOC\n)\tO\n\nMark\tT-2\nKnowles\tT-2\n(\tO\nBahamas\tO\n)\tO\nvs.\tT-0\nMarcelo\tT-1\nFilippini\tT-1\n(\tO\nUruguay\tB-LOC\n)\tO\n\nTodd\tB-PER\nWoodbridge\tI-PER\n(\tO\nAustralia\tO\n)\tO\nvs.\tT-0\nqualifier\tO\n\nTodd\tT-0\nWoodbridge\tT-0\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nqualifier\tT-1\n\nKris\tB-PER\nGoossens\tI-PER\n(\tO\nBelgium\tT-0\n)\tO\nvs.\tO\nSergi\tO\nBruguera\tO\n(\tO\nSpain\tO\n)\tO\n\nKris\tO\nGoossens\tO\n(\tO\nBelgium\tB-LOC\n)\tO\nvs.\tO\nSergi\tT-0\nBruguera\tT-0\n(\tO\nSpain\tO\n)\tO\n\nKris\tT-1\nGoossens\tT-1\n(\tO\nBelgium\tO\n)\tO\nvs.\tT-2\nSergi\tB-PER\nBruguera\tI-PER\n(\tO\nSpain\tT-0\n)\tO\n\nKris\tT-1\nGoossens\tT-1\n(\tO\nBelgium\tT-0\n)\tO\nvs.\tO\nSergi\tO\nBruguera\tO\n(\tO\nSpain\tB-LOC\n)\tO\n\nQualifier\tT-1\nvs.\tT-0\nMichael\tT-2\nStich\tT-2\n(\tO\nGermany\tB-LOC\n)\tT-0\n\nQualifier\tO\nvs.\tT-1\nChuck\tB-PER\nAdams\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n\nQualifier\tT-0\nvs.\tT-1\nChuck\tT-2\nAdams\tT-2\n(\tO\nU.S.\tB-LOC\n)\tO\n\nJavier\tB-PER\nFrana\tI-PER\n(\tO\nArgentina\tT-2\n)\tO\nvs.\tT-0\n3\tO\n-\tO\nThomas\tT-1\nMuster\tT-1\n(\tO\nAustria\tT-3\n)\tT-0\n\nJavier\tO\nFrana\tO\n(\tO\nArgentina\tO\n)\tO\nvs.\tT-1\n3\tO\n-\tO\nThomas\tB-PER\nMuster\tI-PER\n(\tO\nAustria\tT-0\n)\tO\n\nJavier\tT-0\nFrana\tT-0\n(\tO\nArgentina\tO\n)\tO\nvs.\tO\n3\tO\n-\tO\nThomas\tT-1\nMuster\tT-1\n(\tO\nAustria\tB-LOC\n)\tO\n\n8\tO\n-\tO\nJim\tB-PER\nCourier\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\nvs.\tO\nJavier\tO\nSanchez\tO\n(\tO\nSpain\tT-1\n)\tO\n\n8\tO\n-\tO\nJim\tT-0\nCourier\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nJavier\tT-1\nSanchez\tT-1\n(\tO\nSpain\tT-2\n)\tO\n\n8\tO\n-\tO\nJim\tO\nCourier\tO\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-1\nJavier\tB-PER\nSanchez\tI-PER\n(\tO\nSpain\tT-2\n)\tO\n\n8\tO\n-\tO\nJim\tT-0\nCourier\tT-0\n(\tT-2\nU.S.\tT-2\n)\tT-2\nvs.\tO\nJavier\tT-1\nSanchez\tT-1\n(\tO\nSpain\tB-LOC\n)\tO\n\nJim\tB-PER\nGrabb\tI-PER\n(\tO\nU.S.\tT-1\n)\tO\nvs.\tO\nSandon\tT-0\nStolle\tT-0\n(\tO\nAustralia\tO\n)\tO\n\nJim\tO\nGrabb\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tT-1\nSandon\tO\nStolle\tO\n(\tO\nAustralia\tT-0\n)\tT-1\n\nJim\tT-0\nGrabb\tT-0\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-1\nSandon\tB-PER\nStolle\tI-PER\n(\tO\nAustralia\tT-2\n)\tO\n\nJim\tT-1\nGrabb\tT-1\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-0\nSandon\tT-2\nStolle\tT-2\n(\tO\nAustralia\tB-LOC\n)\tT-0\n\nPatrick\tB-PER\nRafter\tI-PER\n(\tO\nAustralia\tO\n)\tO\nvs.\tT-1\nKenneth\tO\nCarlsen\tO\n(\tO\nDenmark\tT-0\n)\tO\n\nPatrick\tO\nRafter\tO\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nKenneth\tT-0\nCarlsen\tT-0\n(\tO\nDenmark\tO\n)\tO\n\nPatrick\tO\nRafter\tO\n(\tO\nAustralia\tO\n)\tO\nvs.\tT-0\nKenneth\tB-PER\nCarlsen\tI-PER\n(\tO\nDenmark\tO\n)\tT-0\n\nPatrick\tO\nRafter\tO\n(\tO\nAustralia\tO\n)\tO\nvs.\tT-0\nKenneth\tO\nCarlsen\tT-1\n(\tO\nDenmark\tB-LOC\n)\tO\n\nJason\tB-PER\nStoltenberg\tI-PER\n(\tO\nAustralia\tO\n)\tO\nvs.\tT-2\nStefano\tT-1\nPescosolido\tT-1\n(\tO\nItaly\tT-0\n)\tO\n\nJason\tO\nStoltenberg\tO\n(\tO\nAustralia\tB-LOC\n)\tO\nvs.\tO\nStefano\tT-0\nPescosolido\tT-0\n(\tO\nItaly\tO\n)\tO\n\nJason\tT-0\nStoltenberg\tT-0\n(\tO\nAustralia\tO\n)\tO\nvs.\tO\nStefano\tB-PER\nPescosolido\tI-PER\n(\tO\nItaly\tO\n)\tO\n\nJason\tO\nStoltenberg\tO\n(\tO\nAustralia\tO\n)\tO\nvs.\tT-0\nStefano\tT-1\nPescosolido\tO\n(\tO\nItaly\tB-LOC\n)\tO\n\nArnaud\tB-PER\nBoetsch\tI-PER\n(\tO\nFrance\tT-1\n)\tO\nvs.\tT-0\nNicolas\tO\nPereira\tO\n(\tO\nVenezuela\tT-2\n)\tO\n\nArnaud\tT-0\nBoetsch\tT-0\n(\tO\nFrance\tB-LOC\n)\tO\nvs.\tO\nNicolas\tO\nPereira\tO\n(\tO\nVenezuela\tT-1\n)\tO\n\nArnaud\tT-0\nBoetsch\tT-0\n(\tO\nFrance\tO\n)\tO\nvs.\tT-1\nNicolas\tB-PER\nPereira\tI-PER\n(\tO\nVenezuela\tO\n)\tO\n\nArnaud\tO\nBoetsch\tO\n(\tO\nFrance\tO\n)\tO\nvs.\tT-0\nNicolas\tO\nPereira\tO\n(\tO\nVenezuela\tB-LOC\n)\tT-0\n\nCarlos\tB-PER\nCosta\tI-PER\n(\tO\nSpain\tT-0\n)\tO\nvs.\tO\nMagnus\tO\nGustafsson\tO\n(\tO\nSweden\tO\n)\tO\n\nCarlos\tT-0\nCosta\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\nvs.\tO\nMagnus\tT-1\nGustafsson\tO\n(\tO\nSweden\tT-2\n)\tO\n\nCarlos\tO\nCosta\tO\n(\tO\nSpain\tO\n)\tO\nvs.\tT-0\nMagnus\tB-PER\nGustafsson\tI-PER\n(\tO\nSweden\tO\n)\tO\n\nJeff\tB-PER\nTarango\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\nvs.\tO\nAlex\tT-2\nRadulescu\tT-2\n(\tO\nGermany\tT-1\n)\tO\n\nJeff\tT-0\nTarango\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nAlex\tO\nRadulescu\tO\n(\tO\nGermany\tO\n)\tO\n\nJeff\tT-0\nTarango\tT-0\n(\tO\nU.S.\tO\n)\tO\nvs.\tO\nAlex\tB-PER\nRadulescu\tI-PER\n(\tO\nGermany\tO\n)\tO\n\nJeff\tO\nTarango\tO\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-0\nAlex\tT-1\nRadulescu\tO\n(\tO\nGermany\tB-LOC\n)\tO\n\nQualifier\tT-1\nvs.\tO\n10\tO\n-\tO\nMarcelo\tB-PER\nRios\tI-PER\n(\tO\nChile\tT-0\n)\tO\n\n15\tO\n-\tO\nMarc\tT-2\nRosset\tT-3\n(\tO\nSwitzerland\tB-LOC\nvs.\tT-1\nJared\tT-1\nPalmer\tO\n(\tO\nU.S.\tO\n)\tO\n\n15\tO\n-\tO\nMarc\tT-1\nRosset\tT-1\n(\tO\nSwitzerland\tO\nvs.\tO\nJared\tT-0\nPalmer\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n\nMartin\tB-PER\nDamm\tI-PER\n(\tO\nCzech\tT-1\nRepublic\tT-1\n)\tO\nvs.\tT-0\nHernan\tO\nGumy\tO\n(\tO\nArgentina\tO\n)\tT-0\n\nMartin\tO\nDamm\tO\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\nvs.\tT-0\nHernan\tO\nGumy\tO\n(\tO\nArgentina\tT-1\n)\tO\n\nMartin\tO\nDamm\tO\n(\tO\nCzech\tT-0\nRepublic\tT-0\n)\tO\nvs.\tO\nHernan\tO\nGumy\tO\n(\tO\nArgentina\tB-LOC\n)\tO\n\nNicklas\tB-PER\nKulti\tI-PER\n(\tO\nSweden\tT-1\n)\tO\nvs.\tT-0\nJakob\tO\nHlasek\tO\n(\tO\nSwitzerland\tO\n)\tT-0\n\nNicklas\tT-0\nKulti\tT-0\n(\tO\nSweden\tB-LOC\n)\tO\nvs.\tO\nJakob\tO\nHlasek\tO\n(\tO\nSwitzerland\tO\n)\tO\n\nNicklas\tT-0\nKulti\tT-0\n(\tO\nSweden\tO\n)\tO\nvs.\tT-1\nJakob\tB-PER\nHlasek\tI-PER\n(\tO\nSwitzerland\tO\n)\tO\n\nNicklas\tO\nKulti\tO\n(\tO\nSweden\tT-1\n)\tO\nvs.\tO\nJakob\tT-0\nHlasek\tT-0\n(\tO\nSwitzerland\tB-LOC\n)\tO\n\nCecil\tB-PER\nMamiit\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\nvs.\tT-2\nAlberto\tT-1\nBerasategui\tT-1\n(\tO\nSpain\tO\n)\tT-2\n\nCecil\tO\nMamiit\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nvs.\tO\nAlberto\tO\nBerasategui\tO\n(\tO\nSpain\tT-0\n)\tO\n\nCecil\tT-0\nMamiit\tT-0\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-1\nAlberto\tB-PER\nBerasategui\tI-PER\n(\tO\nSpain\tT-2\n)\tO\n\nCecil\tT-1\nMamiit\tT-1\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-2\nAlberto\tT-0\nBerasategui\tT-0\n(\tO\nSpain\tB-LOC\n)\tT-2\n\nVince\tB-PER\nSpadea\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\nvs.\tO\nDaniel\tT-1\nVacek\tO\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\n\nVince\tT-1\nSpadea\tT-1\n(\tO\nU.S.\tO\n)\tO\nvs.\tT-0\nDaniel\tB-PER\nVacek\tI-PER\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\n\nVince\tT-0\nSpadea\tT-0\n(\tO\nU.S.\tO\n)\tO\nvs.\tO\nDaniel\tT-1\nVacek\tT-1\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n\nDavid\tB-PER\nPrinosil\tI-PER\n(\tO\nGermany\tT-0\n)\tO\nvs.\tT-2\nqualifier\tT-2\n\nDavid\tT-0\nPrinosil\tT-0\n(\tO\nGermany\tB-LOC\n)\tO\nvs.\tO\nqualifier\tO\n\nQualifier\tO\nvs.\tT-1\nTomas\tB-PER\nCarbonell\tI-PER\n(\tO\nSpain\tT-0\n)\tT-1\n\nQualifier\tT-0\nvs.\tO\nTomas\tT-1\nCarbonell\tT-1\n(\tT-1\nSpain\tB-LOC\n)\tO\n\nQualifier\tT-0\nvs.\tO\n2\tO\n-\tO\nMichael\tB-PER\nChang\tI-PER\n(\tO\nU.S.\tO\n)\tO\n\nQualifier\tT-0\nvs.\tO\n2\tO\n-\tO\nMichael\tO\nChang\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n\nBASEBALL\tO\n-\tO\nORIOLES\tB-ORG\n'\tO\nMANAGER\tT-0\nDAVEY\tO\nJOHNSON\tO\nHOSPITALIZED\tO\n.\tO\n\nBASEBALL\tT-0\n-\tO\nORIOLES\tO\n'\tO\nMANAGER\tO\nDAVEY\tB-PER\nJOHNSON\tI-PER\nHOSPITALIZED\tO\n.\tO\n\nBaltimore\tB-ORG\nOrioles\tI-ORG\nmanager\tT-0\nDavey\tO\nJohnson\tO\nwill\tO\nmiss\tO\nThursday\tO\nnight\tO\n's\tO\ngame\tO\nagainst\tO\nthe\tO\nSeattle\tO\nMariners\tO\nafter\tO\nbeing\tO\nadmitted\tO\nto\tO\na\tO\nhospital\tO\nwith\tO\nan\tO\nirregular\tO\nheartbeat\tO\n.\tO\n\nBaltimore\tO\nOrioles\tO\nmanager\tO\nDavey\tO\nJohnson\tO\nwill\tO\nmiss\tO\nThursday\tT-2\nnight\tT-2\n's\tT-2\ngame\tT-2\nagainst\tT-3\nthe\tT-3\nSeattle\tB-ORG\nMariners\tI-ORG\nafter\tO\nbeing\tO\nadmitted\tT-0\nto\tO\na\tO\nhospital\tT-1\nwith\tO\nan\tO\nirregular\tO\nheartbeat\tO\n.\tO\n\nThe\tO\n53-year-old\tT-0\nJohnson\tB-PER\nwas\tO\nhospitalized\tT-1\nafter\tO\nexperiencing\tO\ndizziness\tO\n.\tT-0\n\n\"\tO\nHe\tO\nis\tO\nin\tO\nno\tO\ndanger\tO\nand\tO\nwill\tO\nbe\tO\ntreated\tO\nand\tO\nobserved\tO\nthis\tO\nevening\tO\n,\tO\n\"\tO\nsaid\tT-0\nOrioles\tB-ORG\nteam\tT-3\nphysician\tO\nDr.\tO\nWilliam\tO\nGoldiner\tO\n,\tO\nadding\tO\nthat\tO\nJohnson\tO\nis\tO\nexpected\tT-1\nto\tO\nbe\tO\nreleased\tT-2\non\tO\nFriday\tO\n.\tO\n\n\"\tO\nHe\tO\nis\tO\nin\tO\nno\tO\ndanger\tO\nand\tO\nwill\tO\nbe\tO\ntreated\tO\nand\tO\nobserved\tO\nthis\tO\nevening\tO\n,\tO\n\"\tO\nsaid\tO\nOrioles\tT-1\nteam\tO\nphysician\tT-0\nDr.\tT-3\nWilliam\tB-PER\nGoldiner\tI-PER\n,\tO\nadding\tO\nthat\tO\nJohnson\tT-2\nis\tO\nexpected\tO\nto\tO\nbe\tO\nreleased\tO\non\tO\nFriday\tO\n.\tO\n\n\"\tO\nHe\tO\nis\tO\nin\tO\nno\tO\ndanger\tO\nand\tO\nwill\tO\nbe\tO\ntreated\tT-1\nand\tO\nobserved\tT-2\nthis\tO\nevening\tO\n,\tO\n\"\tO\nsaid\tO\nOrioles\tT-4\nteam\tO\nphysician\tO\nDr.\tT-5\nWilliam\tT-5\nGoldiner\tT-5\n,\tO\nadding\tO\nthat\tO\nJohnson\tB-PER\nis\tT-0\nexpected\tT-3\nto\tT-3\nbe\tT-3\nreleased\tT-3\non\tO\nFriday\tO\n.\tO\n\nOrioles\tB-ORG\n'\tO\nbench\tT-1\ncoach\tO\nAndy\tT-2\nEtchebarren\tT-2\nwill\tO\nmanage\tT-0\nthe\tO\nclub\tO\nin\tO\nJohnson\tO\n's\tO\nabsence\tO\n.\tO\n\nOrioles\tO\n'\tO\nbench\tO\ncoach\tT-0\nAndy\tB-PER\nEtchebarren\tI-PER\nwill\tO\nmanage\tO\nthe\tO\nclub\tO\nin\tO\nJohnson\tO\n's\tO\nabsence\tO\n.\tO\n\nOrioles\tO\n'\tO\nbench\tO\ncoach\tT-1\nAndy\tO\nEtchebarren\tO\nwill\tO\nmanage\tO\nthe\tO\nclub\tT-0\nin\tO\nJohnson\tB-PER\n's\tO\nabsence\tO\n.\tO\n\nJohnson\tB-PER\nis\tO\nthe\tO\nsecond\tO\nmanager\tT-2\nto\tO\nbe\tO\nhospitalized\tT-0\nthis\tO\nweek\tO\nafter\tO\nCalifornia\tO\nAngels\tO\nskipper\tO\nJohn\tO\nMcNamara\tO\nwas\tO\nadmitted\tO\nto\tO\nNew\tO\nYork\tO\n's\tO\nColumbia\tO\nPresbyterian\tO\nHospital\tO\non\tO\nWednesday\tO\nwith\tO\na\tO\nblood\tT-1\nclot\tT-1\nin\tO\nhis\tO\nleft\tO\ncalf\tO\n.\tO\n\nJohnson\tO\nis\tO\nthe\tO\nsecond\tO\nmanager\tT-1\nto\tO\nbe\tO\nhospitalized\tO\nthis\tO\nweek\tO\nafter\tT-0\nCalifornia\tB-ORG\nAngels\tI-ORG\nskipper\tT-2\nJohn\tO\nMcNamara\tO\nwas\tO\nadmitted\tO\nto\tO\nNew\tO\nYork\tO\n's\tO\nColumbia\tO\nPresbyterian\tO\nHospital\tO\non\tO\nWednesday\tO\nwith\tO\na\tO\nblood\tO\nclot\tO\nin\tO\nhis\tO\nleft\tO\ncalf\tO\n.\tO\n\nJohnson\tT-0\nis\tO\nthe\tO\nsecond\tO\nmanager\tO\nto\tO\nbe\tO\nhospitalized\tO\nthis\tO\nweek\tO\nafter\tO\nCalifornia\tO\nAngels\tO\nskipper\tO\nJohn\tB-PER\nMcNamara\tI-PER\nwas\tO\nadmitted\tO\nto\tO\nNew\tO\nYork\tO\n's\tO\nColumbia\tO\nPresbyterian\tO\nHospital\tO\non\tO\nWednesday\tO\nwith\tO\na\tO\nblood\tO\nclot\tO\nin\tO\nhis\tO\nleft\tO\ncalf\tO\n.\tO\n\nJohnson\tO\nis\tO\nthe\tO\nsecond\tO\nmanager\tO\nto\tO\nbe\tO\nhospitalized\tT-1\nthis\tO\nweek\tO\nafter\tO\nCalifornia\tO\nAngels\tO\nskipper\tO\nJohn\tO\nMcNamara\tO\nwas\tO\nadmitted\tT-0\nto\tO\nNew\tB-LOC\nYork\tI-LOC\n's\tO\nColumbia\tO\nPresbyterian\tO\nHospital\tO\non\tO\nWednesday\tO\nwith\tO\na\tO\nblood\tO\nclot\tO\nin\tO\nhis\tO\nleft\tO\ncalf\tO\n.\tO\n\nJohnson\tO\nis\tO\nthe\tO\nsecond\tT-0\nmanager\tO\nto\tO\nbe\tO\nhospitalized\tT-1\nthis\tO\nweek\tO\nafter\tO\nCalifornia\tO\nAngels\tO\nskipper\tO\nJohn\tO\nMcNamara\tO\nwas\tO\nadmitted\tT-2\nto\tO\nNew\tO\nYork\tO\n's\tO\nColumbia\tB-LOC\nPresbyterian\tI-LOC\nHospital\tI-LOC\non\tO\nWednesday\tO\nwith\tO\na\tO\nblood\tO\nclot\tO\nin\tO\nhis\tO\nleft\tO\ncalf\tO\n.\tO\n\nJohnson\tB-PER\n,\tO\nwho\tO\nplayed\tO\neight\tO\nseasons\tO\nin\tO\nBaltimore\tT-1\n,\tO\nwas\tO\nnamed\tO\nOrioles\tO\nmanager\tO\nin\tO\nthe\tO\noff-season\tO\nreplacing\tT-0\nPhil\tO\nRegan\tO\n.\tO\n\nJohnson\tT-1\n,\tO\nwho\tO\nplayed\tO\neight\tT-2\nseasons\tT-4\nin\tT-0\nBaltimore\tB-LOC\n,\tO\nwas\tO\nnamed\tO\nOrioles\tO\nmanager\tT-3\nin\tO\nthe\tO\noff-season\tO\nreplacing\tO\nPhil\tO\nRegan\tO\n.\tO\n\nJohnson\tO\n,\tO\nwho\tO\nplayed\tO\neight\tO\nseasons\tO\nin\tO\nBaltimore\tO\n,\tO\nwas\tO\nnamed\tO\nOrioles\tB-ORG\nmanager\tT-0\nin\tO\nthe\tO\noff-season\tO\nreplacing\tO\nPhil\tO\nRegan\tO\n.\tO\n\nJohnson\tO\n,\tO\nwho\tO\nplayed\tT-1\neight\tO\nseasons\tO\nin\tO\nBaltimore\tO\n,\tO\nwas\tO\nnamed\tT-0\nOrioles\tO\nmanager\tO\nin\tO\nthe\tO\noff-season\tO\nreplacing\tT-2\nPhil\tB-PER\nRegan\tI-PER\n.\tO\n\nHe\tO\nled\tT-0\nthe\tT-0\nCincinnati\tB-ORG\nReds\tI-ORG\nto\tO\nthe\tO\nNational\tT-2\nLeague\tT-2\nChampionship\tT-2\nSeries\tO\nlast\tO\nyear\tO\nand\tO\nguided\tO\nthe\tO\nNew\tO\nYork\tO\nMets\tO\nto\tO\na\tO\nWorld\tO\nSeries\tO\nchampionship\tT-1\nin\tO\n1986\tO\n.\tO\n\nHe\tO\nled\tO\nthe\tO\nCincinnati\tT-0\nReds\tT-0\nto\tT-2\nthe\tT-2\nNational\tB-MISC\nLeague\tI-MISC\nChampionship\tI-MISC\nSeries\tI-MISC\nlast\tO\nyear\tO\nand\tO\nguided\tO\nthe\tO\nNew\tT-1\nYork\tT-1\nMets\tO\nto\tO\na\tO\nWorld\tO\nSeries\tO\nchampionship\tO\nin\tO\n1986\tO\n.\tO\n\nHe\tO\nled\tO\nthe\tO\nCincinnati\tT-0\nReds\tO\nto\tO\nthe\tO\nNational\tO\nLeague\tO\nChampionship\tO\nSeries\tO\nlast\tO\nyear\tO\nand\tO\nguided\tO\nthe\tT-1\nNew\tB-ORG\nYork\tI-ORG\nMets\tI-ORG\nto\tO\na\tO\nWorld\tT-2\nSeries\tT-2\nchampionship\tT-2\nin\tO\n1986\tO\n.\tO\n\nHe\tO\nled\tO\nthe\tO\nCincinnati\tT-3\nReds\tO\nto\tO\nthe\tO\nNational\tO\nLeague\tO\nChampionship\tT-0\nSeries\tO\nlast\tO\nyear\tO\nand\tO\nguided\tO\nthe\tO\nNew\tO\nYork\tO\nMets\tT-1\nto\tO\na\tO\nWorld\tB-MISC\nSeries\tI-MISC\nchampionship\tT-2\nin\tO\n1986\tO\n.\tO\n\nBaltimore\tB-ORG\nhas\tO\nwon\tT-0\n16\tO\nof\tO\nits\tO\nlast\tO\n22\tO\ngames\tO\nto\tO\npull\tO\nwithin\tO\nfive\tO\ngames\tO\nof\tO\nthe\tO\nslumping\tO\nNew\tO\nYork\tO\nYankees\tO\nin\tO\nthe\tO\nAmerican\tT-1\nLeague\tO\nEast\tO\nDivision\tO\n.\tO\n\nBaltimore\tT-3\nhas\tO\nwon\tO\n16\tO\nof\tO\nits\tO\nlast\tO\n22\tO\ngames\tO\nto\tO\npull\tO\nwithin\tO\nfive\tO\ngames\tO\nof\tO\nthe\tO\nslumping\tT-4\nNew\tB-ORG\nYork\tI-ORG\nYankees\tI-ORG\nin\tT-0\nthe\tO\nAmerican\tT-1\nLeague\tT-2\nEast\tO\nDivision\tO\n.\tO\n\nBaltimore\tO\nhas\tO\nwon\tO\n16\tO\nof\tO\nits\tO\nlast\tO\n22\tO\ngames\tO\nto\tO\npull\tO\nwithin\tO\nfive\tO\ngames\tO\nof\tO\nthe\tO\nslumping\tT-0\nNew\tT-0\nYork\tT-0\nYankees\tT-0\nin\tT-0\nthe\tT-0\nAmerican\tB-MISC\nLeague\tI-MISC\nEast\tI-MISC\nDivision\tI-MISC\n.\tO\n\nNEW\tB-ORG\nYORK\tI-ORG\n72\tT-0\n53\tT-0\n.576\tT-0\n-\tO\n\nBOSTON\tB-ORG\n63\tO\n64\tO\n.496\tO\n10\tT-0\n\nTORONTO\tB-ORG\n58\tT-0\n69\tO\n.457\tO\n15\tT-0\n\nCLEVELAND\tB-ORG\n76\tT-0\n51\tT-0\n.598\tT-0\n-\tT-0\n\nCHICAGO\tB-ORG\n69\tT-0\n59\tT-0\n.539\tT-0\n7\tT-0\n1/2\tT-0\n\nSEATTLE\tB-ORG\n64\tT-0\n61\tT-0\n.512\tT-0\n8\tT-0\n\nOAKLAND\tB-ORG\n62\tT-0\n67\tT-0\n.481\tT-0\n12\tT-0\n\nCALIFORNIA\tB-ORG\n58\tT-0\n68\tT-0\n.460\tT-0\n14\tT-0\n1/2\tT-0\n\nOAKLAND\tB-ORG\nAT\tO\nBOSTON\tT-0\n\nOAKLAND\tT-0\nAT\tO\nBOSTON\tB-LOC\n\nSEATTLE\tB-ORG\nAT\tT-0\nBALTIMORE\tO\n\nSEATTLE\tT-0\nAT\tO\nBALTIMORE\tB-LOC\n\nCALIFORNIA\tB-ORG\nAT\tT-0\nNEW\tT-1\nYORK\tT-1\n\nCALIFORNIA\tT-0\nAT\tO\nNEW\tB-LOC\nYORK\tI-LOC\n\nTORONTO\tT-0\nAT\tT-1\nCHICAGO\tB-LOC\n\nDETROIT\tB-ORG\nAT\tO\nKANSAS\tT-0\nCITY\tO\n\nDETROIT\tO\nAT\tT-0\nKANSAS\tB-LOC\nCITY\tI-LOC\n\nTEXAS\tB-ORG\nAT\tT-0\nMINNESOTA\tO\n\nTEXAS\tT-0\nAT\tT-0\nMINNESOTA\tB-LOC\n\nMONTREAL\tB-ORG\n67\tT-0\n58\tT-0\n.536\tT-0\n12\tT-0\n\nPHILADELPHIA\tB-ORG\n52\tT-0\n75\tT-0\n.409\tT-0\n28\tT-0\n\nCHICAGO\tB-ORG\n63\tT-0\n62\tT-0\n.504\tT-0\n4\tT-0\n\nCINCINNATI\tB-ORG\n62\tT-0\n62\tT-0\n.500\tT-0\n4\tT-0\n1/2\tT-0\n\nPITTSBURGH\tB-ORG\n53\tT-0\n73\tT-0\n.421\tT-0\n14\tT-0\n1/2\tT-0\n\nCOLORADO\tB-ORG\n65\tT-0\n62\tT-0\n.512\tT-0\n4\tT-0\n\nSAN\tB-ORG\nFRANCISCO\tI-ORG\n54\tT-0\n70\tT-0\n.435\tT-0\n13\tT-0\n1/2\tT-0\n\nST\tT-0\nLOUIS\tT-0\nAT\tT-1\nCOLORADO\tB-LOC\n\nCINCINNATI\tB-ORG\nAT\tT-0\nATLANTA\tO\n\nPITTSBURGH\tB-ORG\nAT\tT-0\nHOUSTON\tT-1\n\nPITTSBURGH\tT-0\nAT\tO\nHOUSTON\tB-LOC\n\nPHILADELPHIA\tB-ORG\nAT\tT-0\nLOS\tT-1\nANGELES\tT-1\n\nPHILADELPHIA\tT-0\nAT\tT-1\nLOS\tB-LOC\nANGELES\tI-LOC\n\nMONTREAL\tB-ORG\nAT\tO\nSAN\tO\nFRANCISCO\tT-0\n\nResults\tT-0\nof\tO\nMajor\tB-MISC\nLeague\tI-MISC\n\nCalifornia\tB-ORG\n7\tT-0\nNEW\tO\nYORK\tO\n1\tO\n\nCalifornia\tO\n7\tT-0\nNEW\tB-ORG\nYORK\tI-ORG\n1\tT-1\n\nDETROIT\tB-ORG\n7\tO\nChicago\tT-0\n4\tO\n\nMilwaukee\tB-ORG\n10\tO\nMINNESOTA\tT-0\n7\tO\n\nMilwaukee\tT-2\n10\tT-0\nMINNESOTA\tB-ORG\n7\tT-1\n\nBOSTON\tT-0\n6\tO\nOakland\tB-ORG\n4\tO\n\nBALTIMORE\tB-ORG\n10\tT-0\nSeattle\tO\n5\tT-1\n\nBALTIMORE\tT-0\n10\tO\nSeattle\tB-ORG\n5\tO\n\nTexas\tB-ORG\n10\tO\nCLEVELAND\tT-0\n8\tO\n(\tO\nin\tO\n10\tO\n)\tO\n\nTexas\tT-1\n10\tT-1\nCLEVELAND\tB-ORG\n8\tT-0\n(\tO\nin\tO\n10\tO\n)\tO\n\nToronto\tB-ORG\n6\tT-0\nKANSAS\tO\nCITY\tO\n2\tO\n\nToronto\tT-0\n6\tO\nKANSAS\tB-ORG\nCITY\tI-ORG\n2\tO\n\nCHICAGO\tB-ORG\n8\tT-0\nFlorida\tT-1\n3\tO\n\nCHICAGO\tT-0\n8\tO\nFlorida\tB-ORG\n3\tO\n\nSAN\tB-ORG\nFRANCISCO\tI-ORG\n12\tO\nNew\tT-0\nYork\tT-0\n11\tO\n\nSAN\tT-0\nFRANCISCO\tT-0\n12\tO\nNew\tB-ORG\nYork\tI-ORG\n11\tO\n\nATLANTA\tB-ORG\n4\tT-0\nCincinnati\tO\n3\tO\n\nATLANTA\tO\n4\tO\nCincinnati\tB-ORG\n3\tT-0\n\nPittsburgh\tB-ORG\n5\tT-0\nHOUSTON\tO\n2\tO\n\nPittsburgh\tT-0\n5\tO\nHOUSTON\tB-ORG\n2\tO\n\nCOLORADO\tB-ORG\n10\tT-0\nSt\tT-0\nLouis\tT-0\n2\tT-0\n\nCOLORADO\tT-0\n10\tT-0\nSt\tB-ORG\nLouis\tI-ORG\n2\tO\n\nPhiladelphia\tB-ORG\n6\tO\nLOS\tT-0\nANGELES\tT-0\n0\tO\n\nSAN\tB-ORG\nDIEGO\tI-ORG\n7\tO\nMontreal\tT-0\n2\tO\n\nSAN\tT-1\nDIEGO\tT-1\n7\tO\nMontreal\tB-ORG\n2\tT-0\n\nBASEBALL\tT-0\n-\tO\nGREER\tB-PER\nHOMER\tO\nIN\tO\n10TH\tO\nLIFTS\tO\nTEXAS\tO\nPAST\tO\nINDIANS\tO\n.\tO\n\nBASEBALL\tT-1\n-\tO\nGREER\tT-0\nHOMER\tT-0\nIN\tO\n10TH\tO\nLIFTS\tO\nTEXAS\tB-ORG\nPAST\tO\nINDIANS\tO\n.\tO\n\nBASEBALL\tT-0\n-\tO\nGREER\tO\nHOMER\tO\nIN\tO\n10TH\tO\nLIFTS\tO\nTEXAS\tO\nPAST\tO\nINDIANS\tB-ORG\n.\tO\n\nRusty\tB-PER\nGreer\tI-PER\n's\tO\ntwo-run\tT-1\nhomer\tT-2\nin\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\n10th\tO\ninning\tO\nrallied\tO\nthe\tO\nTexas\tO\nRangers\tO\nto\tO\na\tO\n10-8\tO\nvictory\tO\nover\tO\nthe\tO\nCleveland\tO\nIndians\tO\nWednesday\tO\nin\tO\nthe\tO\nrubber\tO\ngame\tT-0\nof\tO\na\tO\nthree-game\tO\nseries\tO\nbetween\tO\ndivision\tO\nleaders\tO\n.\tO\n\nRusty\tT-2\nGreer\tT-2\n's\tO\ntwo-run\tT-0\nhomer\tT-0\nin\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\n10th\tO\ninning\tO\nrallied\tO\nthe\tT-1\nTexas\tB-ORG\nRangers\tI-ORG\nto\tO\na\tO\n10-8\tO\nvictory\tO\nover\tO\nthe\tO\nCleveland\tT-3\nIndians\tO\nWednesday\tO\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\na\tO\nthree-game\tO\nseries\tO\nbetween\tO\ndivision\tO\nleaders\tO\n.\tO\n\nRusty\tO\nGreer\tO\n's\tO\ntwo-run\tO\nhomer\tO\nin\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\n10th\tO\ninning\tO\nrallied\tO\nthe\tO\nTexas\tO\nRangers\tO\nto\tO\na\tO\n10-8\tO\nvictory\tO\nover\tO\nthe\tO\nCleveland\tB-ORG\nIndians\tI-ORG\nWednesday\tT-0\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\na\tO\nthree-game\tO\nseries\tO\nbetween\tO\ndivision\tT-1\nleaders\tT-1\n.\tO\n\nWith\tO\none\tO\nout\tO\n,\tO\nGreer\tB-PER\nhit\tT-1\na\tO\n1-1\tO\npitch\tT-0\nfrom\tO\nJulian\tT-2\nTavarez\tT-2\n(\tO\n4-7\tO\n)\tO\nover\tO\nthe\tO\nright-field\tO\nfence\tO\nfor\tO\nhis\tO\n15th\tO\nhome\tO\nrun\tO\n.\tO\n\nWith\tO\none\tO\nout\tO\n,\tO\nGreer\tT-1\nhit\tO\na\tO\n1-1\tT-2\npitch\tO\nfrom\tO\nJulian\tB-PER\nTavarez\tI-PER\n(\tO\n4-7\tO\n)\tO\nover\tO\nthe\tO\nright-field\tO\nfence\tT-0\nfor\tO\nhis\tO\n15th\tT-3\nhome\tO\nrun\tO\n.\tO\n\n\"\tO\nIt\tO\nwas\tO\nan\tO\noff-speed\tO\npitch\tO\nand\tO\nI\tO\njust\tO\ntried\tO\nto\tO\nget\tO\na\tO\ngood\tT-1\nswing\tT-2\non\tO\nit\tO\nand\tO\nput\tO\nit\tO\nin\tO\nplay\tT-0\n,\tO\n\"\tO\nGreer\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\nThe\tO\nshot\tT-1\nbrought\tO\nhome\tO\nIvan\tB-PER\nRodriguez\tI-PER\n,\tO\nwho\tO\nhad\tT-0\nhis\tT-0\nsecond\tT-0\ndouble\tT-0\nof\tO\nthe\tO\ngame\tO\n,\tO\ngiving\tO\nhim\tO\n42\tO\nthis\tO\nseason\tO\n,\tO\n41\tO\nas\tO\na\tO\ncatcher\tO\n.\tO\n\nHe\tO\njoined\tT-0\nMickey\tB-PER\nCochrane\tI-PER\n,\tO\nJohnny\tO\nBench\tO\nand\tO\nTerry\tO\nKennedy\tO\nas\tO\nthe\tO\nonly\tO\ncatchers\tT-1\nwith\tO\n40\tO\ndoubles\tO\nin\tO\na\tO\nseason\tO\n.\tO\n\nHe\tT-0\njoined\tT-0\nMickey\tT-2\nCochrane\tT-2\n,\tO\nJohnny\tB-PER\nBench\tI-PER\nand\tO\nTerry\tO\nKennedy\tO\nas\tO\nthe\tO\nonly\tO\ncatchers\tT-1\nwith\tO\n40\tO\ndoubles\tO\nin\tO\na\tO\nseason\tO\n.\tO\n\nHe\tO\njoined\tT-1\nMickey\tO\nCochrane\tO\n,\tO\nJohnny\tO\nBench\tO\nand\tO\nTerry\tB-PER\nKennedy\tI-PER\nas\tO\nthe\tO\nonly\tO\ncatchers\tT-0\nwith\tO\n40\tO\ndoubles\tO\nin\tO\na\tO\nseason\tO\n.\tO\n\nThe\tT-2\nRangers\tB-ORG\nhave\tO\nwon\tO\n10\tO\nof\tO\ntheir\tO\nlast\tO\n12\tO\ngames\tO\nand\tO\nsix\tO\nof\tO\nnine\tO\nmeetings\tT-1\nagainst\tO\nthe\tO\nIndians\tT-0\nthis\tO\nseason\tO\n.\tO\n\nThe\tO\nRangers\tO\nhave\tO\nwon\tT-1\n10\tO\nof\tO\ntheir\tO\nlast\tO\n12\tO\ngames\tT-0\nand\tO\nsix\tO\nof\tO\nnine\tO\nmeetings\tO\nagainst\tO\nthe\tO\nIndians\tB-ORG\nthis\tO\nseason\tO\n.\tO\n\nThe\tT-0\nAmerican\tB-MISC\nLeague\tI-MISC\nWestern\tI-MISC\nleaders\tT-1\nhave\tT-1\nwon\tT-1\neight\tT-1\nof\tT-1\n15\tT-1\ngames\tT-1\nat\tO\nJacobs\tO\nField\tO\n,\tO\njoining\tO\nthe\tO\nYankees\tO\nas\tO\nthe\tO\nonly\tO\nteams\tO\nwith\tO\na\tO\nwinning\tO\nrecord\tO\nat\tO\nthe\tO\nA.L.\tO\nCentral\tO\nleaders\tO\n'\tO\nhome\tO\n.\tO\n\nThe\tO\nAmerican\tT-1\nLeague\tT-1\nWestern\tT-1\nleaders\tO\nhave\tO\nwon\tO\neight\tO\nof\tO\n15\tO\ngames\tO\nat\tT-0\nJacobs\tB-LOC\nField\tI-LOC\n,\tO\njoining\tO\nthe\tO\nYankees\tO\nas\tO\nthe\tO\nonly\tO\nteams\tO\nwith\tO\na\tO\nwinning\tO\nrecord\tO\nat\tO\nthe\tO\nA.L.\tT-2\nCentral\tT-2\nleaders\tO\n'\tO\nhome\tT-3\n.\tO\n\nThe\tO\nAmerican\tO\nLeague\tO\nWestern\tO\nleaders\tO\nhave\tO\nwon\tO\neight\tO\nof\tO\n15\tO\ngames\tO\nat\tO\nJacobs\tO\nField\tO\n,\tO\njoining\tO\nthe\tO\nYankees\tB-ORG\nas\tO\nthe\tO\nonly\tO\nteams\tO\nwith\tO\na\tO\nwinning\tT-1\nrecord\tT-0\nat\tO\nthe\tO\nA.L.\tO\nCentral\tO\nleaders\tO\n'\tO\nhome\tO\n.\tO\n\nThe\tO\nAmerican\tO\nLeague\tO\nWestern\tO\nleaders\tO\nhave\tO\nwon\tO\neight\tO\nof\tO\n15\tO\ngames\tO\nat\tO\nJacobs\tO\nField\tO\n,\tO\njoining\tO\nthe\tO\nYankees\tO\nas\tO\nthe\tO\nonly\tO\nteams\tO\nwith\tO\na\tT-0\nwinning\tT-0\nrecord\tT-0\nat\tT-0\nthe\tT-3\nA.L.\tB-MISC\nCentral\tI-MISC\nleaders\tT-2\n'\tT-1\nhome\tT-1\n.\tO\n\nThe\tO\nIndians\tB-ORG\nsent\tO\nthe\tO\ngame\tT-0\ninto\tO\nextra\tO\ninnings\tO\nin\tO\nthe\tO\nninth\tO\non\tO\nKenny\tO\nLofton\tO\n's\tO\ntwo-run\tO\nsingle\tO\n.\tO\n\nThe\tT-0\nIndians\tT-0\nsent\tO\nthe\tO\ngame\tO\ninto\tO\nextra\tO\ninnings\tO\nin\tO\nthe\tO\nninth\tO\non\tT-2\nKenny\tB-PER\nLofton\tI-PER\n's\tO\ntwo-run\tT-1\nsingle\tO\n.\tO\n\nEd\tB-PER\nVosberg\tI-PER\n(\tO\n1-0\tO\n)\tO\nblew\tT-1\nhis\tO\nfirst\tT-2\nsave\tT-2\nopportunity\tT-2\nbut\tO\ngot\tO\nthe\tO\nwin\tT-3\n,\tO\nallowing\tO\nthree\tO\nhits\tO\nwith\tO\ntwo\tO\nwalks\tO\nand\tO\nthree\tO\nstrikeouts\tO\nin\tO\n1\tO\n2/3\tO\nscoreless\tO\ninnings\tO\n.\tO\n\nDean\tB-PER\nPalmer\tI-PER\nhit\tT-1\nhis\tO\n30th\tO\nhomer\tT-2\nfor\tO\nthe\tO\nRangers\tO\n.\tO\n\nDean\tT-0\nPalmer\tT-0\nhit\tO\nhis\tO\n30th\tO\nhomer\tO\nfor\tO\nthe\tT-1\nRangers\tB-ORG\n.\tO\n\nIn\tO\nBaltimore\tB-LOC\n,\tO\nCal\tO\nRipken\tO\nhad\tO\nfour\tO\nhits\tT-1\nand\tO\nsnapped\tO\na\tO\nfifth-inning\tO\ntie\tO\nwith\tO\na\tO\nsolo\tO\nhomer\tO\nand\tO\nBobby\tO\nBonilla\tO\nadded\tO\na\tO\nthree-run\tO\nshot\tO\nin\tT-0\nthe\tO\nseventh\tT-2\nto\tO\npower\tO\nthe\tO\nsurging\tO\nOrioles\tO\nto\tO\na\tO\n10-5\tO\nvictory\tO\nover\tO\nthe\tO\nSeattle\tO\nMariners\tO\n.\tO\n\nIn\tO\nBaltimore\tT-1\n,\tO\nCal\tB-PER\nRipken\tI-PER\nhad\tT-2\nfour\tT-2\nhits\tT-2\nand\tO\nsnapped\tO\na\tO\nfifth-inning\tO\ntie\tT-3\nwith\tO\na\tO\nsolo\tO\nhomer\tO\nand\tO\nBobby\tO\nBonilla\tO\nadded\tO\na\tO\nthree-run\tO\nshot\tO\nin\tO\nthe\tO\nseventh\tO\nto\tO\npower\tO\nthe\tO\nsurging\tO\nOrioles\tO\nto\tO\na\tO\n10-5\tO\nvictory\tO\nover\tO\nthe\tO\nSeattle\tO\nMariners\tO\n.\tT-3\n\nIn\tO\nBaltimore\tO\n,\tO\nCal\tO\nRipken\tO\nhad\tO\nfour\tO\nhits\tO\nand\tO\nsnapped\tT-1\na\tO\nfifth-inning\tO\ntie\tO\nwith\tO\na\tO\nsolo\tT-0\nhomer\tO\nand\tO\nBobby\tB-PER\nBonilla\tI-PER\nadded\tT-2\na\tO\nthree-run\tO\nshot\tO\nin\tO\nthe\tO\nseventh\tO\nto\tO\npower\tO\nthe\tO\nsurging\tO\nOrioles\tO\nto\tO\na\tO\n10-5\tO\nvictory\tO\nover\tO\nthe\tO\nSeattle\tO\nMariners\tO\n.\tT-0\n\nIn\tO\nBaltimore\tT-1\n,\tO\nCal\tO\nRipken\tO\nhad\tO\nfour\tO\nhits\tO\nand\tO\nsnapped\tO\na\tO\nfifth-inning\tO\ntie\tO\nwith\tO\na\tO\nsolo\tO\nhomer\tO\nand\tO\nBobby\tO\nBonilla\tO\nadded\tO\na\tO\nthree-run\tO\nshot\tO\nin\tO\nthe\tO\nseventh\tO\nto\tO\npower\tO\nthe\tO\nsurging\tT-2\nOrioles\tB-ORG\nto\tT-0\na\tT-0\n10-5\tT-0\nvictory\tT-0\nover\tT-0\nthe\tT-0\nSeattle\tT-0\nMariners\tT-0\n.\tO\n\nIn\tO\nBaltimore\tO\n,\tO\nCal\tO\nRipken\tO\nhad\tO\nfour\tO\nhits\tT-0\nand\tO\nsnapped\tO\na\tO\nfifth-inning\tO\ntie\tO\nwith\tO\na\tO\nsolo\tO\nhomer\tT-1\nand\tO\nBobby\tO\nBonilla\tO\nadded\tO\na\tO\nthree-run\tO\nshot\tO\nin\tO\nthe\tO\nseventh\tO\nto\tO\npower\tO\nthe\tO\nsurging\tO\nOrioles\tO\nto\tO\na\tO\n10-5\tO\nvictory\tT-2\nover\tO\nthe\tT-3\nSeattle\tB-ORG\nMariners\tI-ORG\n.\tT-0\n\nThe\tO\nMariners\tB-ORG\nscored\tT-2\nfour\tO\nruns\tT-3\nin\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nfifth\tO\nto\tO\ntie\tO\nthe\tO\ngame\tO\n5-5\tO\nbut\tO\nRipken\tT-0\nled\tO\noff\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\ninning\tT-1\nwith\tO\nhis\tO\n21st\tO\nhomer\tO\noff\tO\nstarter\tO\nSterling\tO\nHitchcock\tO\n(\tO\n12-6\tO\n)\tO\n.\tO\n\nThe\tO\nMariners\tO\nscored\tT-0\nfour\tO\nruns\tO\nin\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nfifth\tO\nto\tO\ntie\tO\nthe\tO\ngame\tO\n5-5\tT-2\nbut\tO\nRipken\tB-PER\nled\tT-1\noff\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\ninning\tO\nwith\tO\nhis\tO\n21st\tT-3\nhomer\tT-3\noff\tO\nstarter\tO\nSterling\tO\nHitchcock\tO\n(\tO\n12-6\tO\n)\tO\n.\tO\n\nThe\tO\nMariners\tT-1\nscored\tT-2\nfour\tO\nruns\tO\nin\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nfifth\tO\nto\tO\ntie\tO\nthe\tO\ngame\tO\n5-5\tO\nbut\tO\nRipken\tO\nled\tO\noff\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\ninning\tO\nwith\tO\nhis\tO\n21st\tO\nhomer\tO\noff\tO\nstarter\tT-0\nSterling\tB-PER\nHitchcock\tI-PER\n(\tO\n12-6\tO\n)\tO\n.\tO\n\nBonilla\tB-PER\n's\tT-0\nblast\tT-0\nwas\tO\nthe\tO\nfirst\tO\ntime\tO\nRandy\tO\nJohnson\tO\n,\tO\nlast\tO\nseason\tO\n's\tO\nCy\tO\nYoung\tO\nwinner\tO\n,\tO\nallowed\tT-1\na\tO\nrun\tO\nin\tO\nfive\tO\nrelief\tO\nappearances\tO\nsince\tO\ncoming\tO\noff\tO\nthe\tO\ndisabled\tT-2\nlist\tO\non\tO\nAugust\tO\n6\tO\n.\tO\n\nBonilla\tO\n's\tO\nblast\tO\nwas\tO\nthe\tO\nfirst\tO\ntime\tO\nRandy\tB-PER\nJohnson\tI-PER\n,\tO\nlast\tO\nseason\tO\n's\tO\nCy\tO\nYoung\tO\nwinner\tO\n,\tO\nallowed\tT-1\na\tO\nrun\tT-2\nin\tO\nfive\tO\nrelief\tO\nappearances\tT-0\nsince\tO\ncoming\tO\noff\tO\nthe\tO\ndisabled\tO\nlist\tO\non\tO\nAugust\tO\n6\tO\n.\tO\n\nBonilla\tO\n's\tO\nblast\tT-1\nwas\tO\nthe\tO\nfirst\tO\ntime\tT-3\nRandy\tT-0\nJohnson\tT-0\n,\tO\nlast\tO\nseason\tO\n's\tO\nCy\tB-PER\nYoung\tI-PER\nwinner\tO\n,\tO\nallowed\tT-2\na\tO\nrun\tO\nin\tO\nfive\tO\nrelief\tO\nappearances\tO\nsince\tO\ncoming\tO\noff\tO\nthe\tO\ndisabled\tO\nlist\tO\non\tO\nAugust\tO\n6\tO\n.\tO\n\nBonilla\tB-PER\nhas\tO\n21\tO\nRBI\tT-0\nand\tO\n15\tT-1\nruns\tT-1\nin\tO\nhis\tO\nlast\tO\n20\tT-2\ngames\tT-2\n.\tO\n\nBonilla\tT-1\nhas\tT-0\n21\tO\nRBI\tB-MISC\nand\tO\n15\tO\nruns\tO\nin\tO\nhis\tO\nlast\tO\n20\tO\ngames\tO\n.\tO\n\nBaltimore\tB-LOC\nhas\tT-2\nwon\tT-2\nseven\tO\nof\tO\nnine\tO\nand\tO\n16\tO\nof\tO\nits\tO\nlast\tO\n22\tO\nand\tO\ncut\tO\nthe\tO\nYankees\tT-0\n'\tO\nlead\tT-1\nin\tO\nthe\tO\nA.L.\tO\nEast\tO\nto\tO\nfive\tO\ngames\tO\n.\tO\n\nBaltimore\tO\nhas\tO\nwon\tO\nseven\tO\nof\tO\nnine\tO\nand\tO\n16\tO\nof\tO\nits\tO\nlast\tO\n22\tO\nand\tO\ncut\tO\nthe\tO\nYankees\tB-ORG\n'\tT-1\nlead\tT-1\nin\tO\nthe\tO\nA.L.\tO\nEast\tO\nto\tO\nfive\tO\ngames\tO\n.\tO\n\nBaltimore\tT-0\nhas\tO\nwon\tO\nseven\tO\nof\tO\nnine\tO\nand\tO\n16\tO\nof\tO\nits\tO\nlast\tO\n22\tO\nand\tO\ncut\tO\nthe\tO\nYankees\tT-1\n'\tO\nlead\tO\nin\tO\nthe\tO\nA.L.\tB-MISC\nEast\tI-MISC\nto\tO\nfive\tO\ngames\tT-2\n.\tO\n\nScott\tB-PER\nErickson\tI-PER\n(\tO\n8-10\tO\n)\tO\nlaboured\tT-0\nto\tO\nhis\tT-1\nthird\tT-2\nstraight\tO\nwin\tT-3\n.\tO\n\nAlex\tB-PER\nRodriguez\tI-PER\nhad\tT-1\ntwo\tT-0\nhomers\tT-0\nand\tO\nfour\tO\nRBI\tO\nfor\tO\nthe\tO\nMariners\tO\n,\tO\nwho\tO\nhave\tO\ndropped\tO\nthree\tO\nin\tO\na\tO\nrow\tO\nand\tO\n11\tO\nof\tO\n15\tO\n.\tO\n\nAlex\tO\nRodriguez\tO\nhad\tO\ntwo\tT-2\nhomers\tT-2\nand\tT-2\nfour\tT-2\nRBI\tB-MISC\nfor\tT-1\nthe\tT-1\nMariners\tO\n,\tO\nwho\tO\nhave\tO\ndropped\tT-0\nthree\tO\nin\tO\na\tO\nrow\tO\nand\tO\n11\tO\nof\tO\n15\tO\n.\tO\n\nAlex\tT-0\nRodriguez\tT-0\nhad\tO\ntwo\tO\nhomers\tO\nand\tO\nfour\tO\nRBI\tO\nfor\tT-1\nthe\tT-1\nMariners\tB-ORG\n,\tO\nwho\tO\nhave\tO\ndropped\tO\nthree\tO\nin\tO\na\tO\nrow\tO\nand\tO\n11\tO\nof\tO\n15\tO\n.\tO\n\nHe\tO\nbecame\tO\nthe\tO\nfifth\tO\nshortstop\tT-0\nin\tO\nmajor-league\tT-1\nhistory\tT-1\nto\tO\nhit\tO\n30\tO\nhomers\tT-2\nin\tO\na\tO\nseason\tO\nand\tO\nthe\tO\nfirst\tO\nsince\tO\nRipken\tB-PER\nhit\tO\n34\tO\nin\tO\n1991\tO\n.\tO\n\nChris\tB-PER\nHoiles\tI-PER\nhit\tO\nhis\tT-1\n22nd\tO\nhomer\tO\nfor\tO\nBaltimore\tT-0\n.\tO\n\nChris\tO\nHoiles\tO\nhit\tT-0\nhis\tO\n22nd\tO\nhomer\tO\nfor\tT-1\nBaltimore\tB-LOC\n.\tO\n\nIn\tO\nNew\tB-LOC\nYork\tI-LOC\n,\tO\nJason\tO\nDickson\tO\nscattered\tT-0\n10\tO\nhits\tO\nover\tO\n6\tO\n1/3\tO\ninnings\tO\nin\tO\nhis\tO\nmajor-league\tO\ndebut\tO\nand\tO\nChili\tO\nDavis\tO\nbelted\tO\na\tO\nhomer\tO\nfrom\tO\neach\tO\nside\tO\nof\tO\nthe\tO\nplate\tO\nas\tO\nthe\tO\nCalifornia\tO\nAngels\tO\ndefeated\tO\nthe\tO\nYankees\tO\n7-1\tO\n.\tO\n\nIn\tO\nNew\tO\nYork\tO\n,\tO\nJason\tT-1\nDickson\tT-1\nscattered\tO\n10\tO\nhits\tO\nover\tO\n6\tO\n1/3\tO\ninnings\tO\nin\tO\nhis\tO\nmajor-league\tO\ndebut\tO\nand\tO\nChili\tB-PER\nDavis\tI-PER\nbelted\tT-0\na\tO\nhomer\tO\nfrom\tO\neach\tO\nside\tO\nof\tO\nthe\tO\nplate\tO\nas\tO\nthe\tO\nCalifornia\tO\nAngels\tO\ndefeated\tO\nthe\tO\nYankees\tO\n7-1\tO\n.\tO\n\nIn\tO\nNew\tO\nYork\tO\n,\tO\nJason\tT-1\nDickson\tT-1\nscattered\tT-0\n10\tO\nhits\tO\nover\tO\n6\tO\n1/3\tO\ninnings\tO\nin\tO\nhis\tO\nmajor-league\tO\ndebut\tO\nand\tO\nChili\tO\nDavis\tO\nbelted\tO\na\tO\nhomer\tO\nfrom\tO\neach\tO\nside\tO\nof\tO\nthe\tO\nplate\tO\nas\tO\nthe\tO\nCalifornia\tB-ORG\nAngels\tI-ORG\ndefeated\tO\nthe\tO\nYankees\tO\n7-1\tO\n.\tO\n\nIn\tO\nNew\tO\nYork\tO\n,\tO\nJason\tT-0\nDickson\tT-0\nscattered\tT-3\n10\tO\nhits\tO\nover\tO\n6\tO\n1/3\tO\ninnings\tO\nin\tO\nhis\tO\nmajor-league\tO\ndebut\tO\nand\tO\nChili\tT-1\nDavis\tT-1\nbelted\tO\na\tO\nhomer\tO\nfrom\tO\neach\tO\nside\tO\nof\tO\nthe\tO\nplate\tO\nas\tO\nthe\tO\nCalifornia\tT-2\nAngels\tT-2\ndefeated\tO\nthe\tO\nYankees\tB-ORG\n7-1\tO\n.\tO\n\nDickson\tB-PER\nallowed\tT-0\na\tO\nhomer\tT-3\nto\tO\nDerek\tT-2\nJeter\tT-2\non\tO\nhis\tO\nfirst\tO\nmajor-league\tO\npitch\tO\nbut\tO\nsettled\tT-1\ndown\tT-1\n.\tO\n\nDickson\tO\nallowed\tT-2\na\tO\nhomer\tO\nto\tT-1\nDerek\tB-PER\nJeter\tI-PER\non\tO\nhis\tO\nfirst\tO\nmajor-league\tT-3\npitch\tT-0\nbut\tO\nsettled\tO\ndown\tO\n.\tO\n\nHe\tO\nwas\tO\nthe\tO\n27th\tT-2\npitcher\tT-2\nused\tO\nby\tT-1\nthe\tT-1\nAngels\tB-ORG\nthis\tO\nseason\tO\n,\tO\ntying\tO\na\tO\nmajor-league\tO\nrecord\tO\n.\tO\n\nJimmy\tB-PER\nKey\tI-PER\n(\tO\n9-10\tO\n)\tO\ntook\tT-0\nthe\tO\nloss\tO\nas\tO\nthe\tO\nYankees\tO\nlost\tO\ntheir\tO\nninth\tO\nin\tO\n14\tO\ngames\tO\n.\tO\n\nJimmy\tT-0\nKey\tT-0\n(\tO\n9-10\tO\n)\tO\ntook\tO\nthe\tO\nloss\tO\nas\tO\nthe\tO\nYankees\tB-ORG\nlost\tO\ntheir\tO\nninth\tO\nin\tO\n14\tO\ngames\tO\n.\tO\n\nCalifornia\tB-LOC\nplayed\tT-0\nwithout\tO\ninterim\tO\nmanager\tO\nJohn\tO\nMcNamara\tO\n,\tO\nwho\tT-1\nwas\tO\nadmitted\tO\nto\tO\na\tO\nNew\tT-2\nYork\tT-2\nhospital\tT-2\nwith\tO\na\tO\nblood\tO\nclot\tO\nin\tO\nhis\tO\nright\tO\ncalf\tO\n.\tO\n\nCalifornia\tT-0\nplayed\tO\nwithout\tO\ninterim\tO\nmanager\tO\nJohn\tB-PER\nMcNamara\tI-PER\n,\tO\nwho\tO\nwas\tO\nadmitted\tO\nto\tO\na\tO\nNew\tO\nYork\tO\nhospital\tO\nwith\tO\na\tO\nblood\tO\nclot\tO\nin\tO\nhis\tO\nright\tO\ncalf\tO\n.\tO\n\nCalifornia\tO\nplayed\tO\nwithout\tO\ninterim\tO\nmanager\tO\nJohn\tO\nMcNamara\tO\n,\tO\nwho\tO\nwas\tO\nadmitted\tT-0\nto\tO\na\tO\nNew\tB-LOC\nYork\tI-LOC\nhospital\tT-2\nwith\tO\na\tO\nblood\tT-1\nclot\tT-1\nin\tO\nhis\tO\nright\tO\ncalf\tO\n.\tO\n\nIn\tT-0\nBoston\tB-LOC\n,\tO\nMike\tO\nStanley\tO\n's\tO\nbases-loaded\tO\ntwo-run\tO\nsingle\tO\nsnapped\tO\nan\tO\neighth-inning\tO\ntie\tO\nand\tO\ngave\tO\nthe\tO\nRed\tO\nSox\tO\ntheir\tO\nthird\tO\nstraight\tO\nwin\tO\n,\tO\n6-4\tO\nover\tO\nthe\tO\nOakland\tO\nAthletics\tO\n.\tO\n\nIn\tT-2\nBoston\tT-2\n,\tO\nMike\tB-PER\nStanley\tI-PER\n's\tO\nbases-loaded\tO\ntwo-run\tO\nsingle\tT-5\nsnapped\tT-5\nan\tO\neighth-inning\tT-3\ntie\tO\nand\tO\ngave\tO\nthe\tO\nRed\tO\nSox\tO\ntheir\tO\nthird\tO\nstraight\tO\nwin\tT-4\n,\tO\n6-4\tO\nover\tO\nthe\tO\nOakland\tT-1\nAthletics\tT-1\n.\tO\n\nIn\tO\nBoston\tO\n,\tO\nMike\tT-0\nStanley\tT-0\n's\tT-0\nbases-loaded\tO\ntwo-run\tO\nsingle\tO\nsnapped\tT-3\nan\tO\neighth-inning\tO\ntie\tO\nand\tO\ngave\tT-4\nthe\tO\nRed\tB-ORG\nSox\tI-ORG\ntheir\tO\nthird\tO\nstraight\tO\nwin\tO\n,\tO\n6-4\tO\nover\tO\nthe\tO\nOakland\tT-2\nAthletics\tT-2\n.\tO\n\nIn\tO\nBoston\tT-0\n,\tO\nMike\tT-1\nStanley\tT-1\n's\tO\nbases-loaded\tO\ntwo-run\tO\nsingle\tO\nsnapped\tO\nan\tO\neighth-inning\tO\ntie\tO\nand\tO\ngave\tO\nthe\tO\nRed\tT-2\nSox\tT-2\ntheir\tO\nthird\tO\nstraight\tO\nwin\tT-4\n,\tO\n6-4\tO\nover\tT-5\nthe\tT-3\nOakland\tB-ORG\nAthletics\tI-ORG\n.\tO\n\nBoston\tB-LOC\n's\tO\nMo\tT-0\nVaughn\tT-0\nwent\tO\n3-for-3\tO\nwith\tO\na\tO\nwalk\tO\n,\tO\nstole\tO\nhome\tO\nfor\tO\none\tO\nof\tO\nhis\tO\nthree\tO\nruns\tO\nscored\tO\nand\tO\ncollected\tO\nhis\tO\n116th\tO\nRBI\tO\n.\tO\n\nBoston\tO\n's\tO\nMo\tB-PER\nVaughn\tI-PER\nwent\tO\n3-for-3\tO\nwith\tO\na\tO\nwalk\tO\n,\tO\nstole\tT-1\nhome\tO\nfor\tO\none\tO\nof\tO\nhis\tT-0\nthree\tO\nruns\tO\nscored\tO\nand\tO\ncollected\tO\nhis\tO\n116th\tO\nRBI\tO\n.\tO\n\nBoston\tO\n's\tO\nMo\tT-2\nVaughn\tT-2\nwent\tT-3\n3-for-3\tT-3\nwith\tO\na\tO\nwalk\tO\n,\tO\nstole\tT-1\nhome\tO\nfor\tO\none\tO\nof\tO\nhis\tO\nthree\tO\nruns\tO\nscored\tO\nand\tO\ncollected\tO\nhis\tO\n116th\tT-0\nRBI\tB-MISC\n.\tO\n\nScott\tB-PER\nBrosius\tI-PER\nhomered\tT-0\nand\tO\ndrove\tO\nin\tO\ntwo\tT-1\nruns\tT-1\nfor\tO\nthe\tO\nAthletics\tO\n,\tO\nwho\tO\nhave\tO\nlost\tO\nseven\tO\nof\tO\ntheir\tO\nlast\tO\nnine\tT-2\ngames\tT-2\n.\tO\n\nScott\tO\nBrosius\tO\nhomered\tT-1\nand\tO\ndrove\tT-2\nin\tO\ntwo\tO\nruns\tT-0\nfor\tO\nthe\tO\nAthletics\tB-ORG\n,\tO\nwho\tO\nhave\tO\nlost\tT-3\nseven\tO\nof\tO\ntheir\tO\nlast\tO\nnine\tO\ngames\tO\n.\tO\n\nIn\tO\nDetroit\tB-LOC\n,\tO\nBrad\tO\nAusmus\tO\n's\tO\nthree-run\tO\nhomer\tO\ncapped\tO\na\tO\nfour-run\tO\neighth\tO\nand\tO\nlifted\tO\nthe\tO\nTigers\tO\nto\tO\na\tO\n7-4\tO\nvictory\tT-0\nover\tO\nthe\tO\nreeling\tO\nChicago\tT-1\nWhite\tT-1\nSox\tT-1\n.\tO\n\nIn\tO\nDetroit\tO\n,\tO\nBrad\tB-PER\nAusmus\tI-PER\n's\tO\nthree-run\tT-1\nhomer\tT-1\ncapped\tO\na\tO\nfour-run\tO\neighth\tO\nand\tO\nlifted\tO\nthe\tO\nTigers\tO\nto\tO\na\tO\n7-4\tO\nvictory\tT-0\nover\tO\nthe\tO\nreeling\tO\nChicago\tO\nWhite\tO\nSox\tO\n.\tO\n\nIn\tT-3\nDetroit\tT-3\n,\tO\nBrad\tT-2\nAusmus\tT-2\n's\tO\nthree-run\tT-4\nhomer\tO\ncapped\tO\na\tO\nfour-run\tO\neighth\tO\nand\tO\nlifted\tT-0\nthe\tT-0\nTigers\tB-ORG\nto\tO\na\tO\n7-4\tO\nvictory\tT-5\nover\tO\nthe\tO\nreeling\tO\nChicago\tO\nWhite\tO\nSox\tO\n.\tO\n\nIn\tO\nDetroit\tO\n,\tO\nBrad\tO\nAusmus\tO\n's\tO\nthree-run\tT-0\nhomer\tO\ncapped\tT-2\na\tO\nfour-run\tO\neighth\tO\nand\tO\nlifted\tO\nthe\tO\nTigers\tO\nto\tO\na\tO\n7-4\tO\nvictory\tO\nover\tT-1\nthe\tO\nreeling\tO\nChicago\tB-ORG\nWhite\tI-ORG\nSox\tI-ORG\n.\tO\n\nThe\tO\nTigers\tB-ORG\nhave\tT-0\nwon\tT-1\nconsecutive\tT-1\ngames\tO\nafter\tO\ndropping\tO\neight\tO\nin\tO\na\tO\nrow\tO\n,\tO\nbut\tO\nhave\tO\nwon\tO\nnine\tO\nof\tO\ntheir\tO\nlast\tO\n12\tO\nat\tO\nhome\tO\n.\tO\n\nThe\tT-0\nWhite\tB-ORG\nSox\tI-ORG\nhave\tO\nlost\tT-1\nsix\tO\nof\tO\ntheir\tO\nlast\tO\neight\tO\ngames\tO\n.\tO\n\nIn\tO\nKansas\tT-2\nCity\tT-2\n,\tO\nJuan\tB-PER\nGuzman\tI-PER\ntossed\tT-0\na\tO\ncomplete-game\tO\nsix-hitter\tO\nto\tO\nwin\tT-3\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nover\tO\na\tO\nmonth\tO\nand\tO\nlower\tO\nhis\tT-1\nleague-best\tO\nERA\tT-4\nas\tO\nthe\tO\nToronto\tT-5\nBlue\tT-5\nJays\tT-5\nwon\tO\ntheir\tO\nfourth\tO\nstraight\tO\n,\tO\n6-2\tO\nover\tO\nthe\tO\nRoyals\tO\n.\tT-4\n\nIn\tO\nKansas\tO\nCity\tO\n,\tO\nJuan\tO\nGuzman\tO\ntossed\tO\na\tO\ncomplete-game\tO\nsix-hitter\tO\nto\tO\nwin\tT-0\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nover\tO\na\tO\nmonth\tO\nand\tO\nlower\tO\nhis\tO\nleague-best\tT-4\nERA\tB-MISC\nas\tO\nthe\tO\nToronto\tT-3\nBlue\tT-3\nJays\tO\nwon\tT-1\ntheir\tO\nfourth\tO\nstraight\tO\n,\tO\n6-2\tO\nover\tO\nthe\tO\nRoyals\tT-2\n.\tO\n\nIn\tO\nKansas\tT-0\nCity\tT-0\n,\tO\nJuan\tO\nGuzman\tO\ntossed\tO\na\tO\ncomplete-game\tO\nsix-hitter\tO\nto\tO\nwin\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nover\tO\na\tO\nmonth\tO\nand\tO\nlower\tO\nhis\tO\nleague-best\tO\nERA\tO\nas\tO\nthe\tO\nToronto\tB-ORG\nBlue\tI-ORG\nJays\tI-ORG\nwon\tT-1\ntheir\tO\nfourth\tO\nstraight\tO\n,\tO\n6-2\tO\nover\tT-2\nthe\tT-2\nRoyals\tT-2\n.\tO\n\nIn\tO\nKansas\tO\nCity\tO\n,\tO\nJuan\tT-1\nGuzman\tT-1\ntossed\tO\na\tO\ncomplete-game\tO\nsix-hitter\tO\nto\tO\nwin\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nover\tO\na\tO\nmonth\tO\nand\tO\nlower\tO\nhis\tO\nleague-best\tO\nERA\tO\nas\tO\nthe\tO\nToronto\tO\nBlue\tO\nJays\tO\nwon\tO\ntheir\tO\nfourth\tO\nstraight\tO\n,\tO\n6-2\tO\nover\tT-0\nthe\tT-0\nRoyals\tB-ORG\n.\tO\n\nGuzman\tB-PER\n(\tO\n10-8\tT-0\n)\tO\nwon\tT-1\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nsince\tO\nJuly\tO\n16\tO\n,\tO\na\tO\nspan\tO\nof\tO\nsix\tO\nstarts\tO\n.\tO\n\nHe\tO\nallowed\tO\ntwo\tO\nruns\tO\n--\tO\none\tO\nearned\tT-1\n--\tO\nand\tO\nlowered\tT-0\nhis\tO\nERA\tB-MISC\nto\tO\n2.99\tO\n.\tO\n\nAt\tT-0\nMinnesota\tB-LOC\n,\tO\nJohn\tT-1\nJaha\tT-1\n's\tT-1\nthree-run\tT-4\nhomer\tT-4\n,\tO\nhis\tO\n26th\tO\n,\tO\ncapped\tT-5\na\tO\nfive-run\tO\neighth\tO\ninning\tO\nthat\tO\nrallied\tO\nthe\tO\nMilwaukee\tT-2\nBrewers\tT-2\nto\tO\na\tO\n10-7\tO\nvictory\tO\nover\tO\nthe\tO\nTwins\tT-3\n.\tO\n\nAt\tO\nMinnesota\tT-1\n,\tO\nJohn\tB-PER\nJaha\tI-PER\n's\tO\nthree-run\tT-0\nhomer\tT-0\n,\tO\nhis\tO\n26th\tO\n,\tO\ncapped\tT-2\na\tO\nfive-run\tO\neighth\tO\ninning\tO\nthat\tO\nrallied\tO\nthe\tO\nMilwaukee\tO\nBrewers\tO\nto\tO\na\tO\n10-7\tO\nvictory\tO\nover\tO\nthe\tO\nTwins\tO\n.\tO\n\nAt\tO\nMinnesota\tO\n,\tO\nJohn\tO\nJaha\tO\n's\tO\nthree-run\tO\nhomer\tO\n,\tO\nhis\tO\n26th\tO\n,\tO\ncapped\tT-3\na\tO\nfive-run\tO\neighth\tO\ninning\tO\nthat\tO\nrallied\tT-0\nthe\tO\nMilwaukee\tB-ORG\nBrewers\tI-ORG\nto\tO\na\tO\n10-7\tO\nvictory\tT-1\nover\tO\nthe\tO\nTwins\tT-2\n.\tO\n\nAt\tO\nMinnesota\tO\n,\tO\nJohn\tT-1\nJaha\tT-1\n's\tO\nthree-run\tO\nhomer\tO\n,\tO\nhis\tO\n26th\tO\n,\tO\ncapped\tT-0\na\tO\nfive-run\tO\neighth\tO\ninning\tT-2\nthat\tO\nrallied\tO\nthe\tO\nMilwaukee\tT-3\nBrewers\tO\nto\tO\na\tO\n10-7\tO\nvictory\tO\nover\tO\nthe\tO\nTwins\tB-ORG\n.\tO\n\nJaha\tB-PER\nadded\tO\nan\tO\nRBI\tT-0\nsingle\tT-1\nin\tO\nthe\tO\nninth\tO\nand\tO\nhad\tO\nfour\tO\nRBI\tO\n.\tO\n\nJaha\tT-1\nadded\tT-0\nan\tT-0\nRBI\tB-MISC\nsingle\tT-2\nin\tT-2\nthe\tT-2\nninth\tT-2\nand\tO\nhad\tO\nfour\tO\nRBI\tO\n.\tO\n\nJaha\tO\nadded\tT-1\nan\tO\nRBI\tO\nsingle\tO\nin\tO\nthe\tO\nninth\tO\nand\tT-0\nhad\tT-0\nfour\tT-0\nRBI\tB-MISC\n.\tO\n\nJose\tB-PER\nValentin\tI-PER\nhit\tT-0\nhis\tT-0\n21st\tO\nhomer\tO\nfor\tO\nMilwaukee\tO\n.\tO\n\nJose\tO\nValentin\tO\nhit\tO\nhis\tO\n21st\tO\nhomer\tO\nfor\tT-0\nMilwaukee\tB-ORG\n.\tO\n\nSOCCER\tO\n-\tO\nCOCU\tB-PER\nDOUBLE\tT-0\nEARNS\tT-1\nPSV\tO\n4-1\tO\nWIN\tT-2\n.\tO\n\nSOCCER\tT-2\n-\tO\nCOCU\tT-1\nDOUBLE\tT-1\nEARNS\tT-0\nPSV\tB-ORG\n4-1\tO\nWIN\tO\n.\tO\n\nPhilip\tB-PER\nCocu\tI-PER\nscored\tT-2\ntwice\tT-3\nin\tO\nthe\tO\nsecond\tO\nhalf\tO\nto\tO\nspur\tO\nPSV\tT-0\nEindhoven\tT-0\nto\tO\na\tO\n4-1\tO\naway\tO\nwin\tT-4\nover\tO\nNEC\tT-1\nNijmegen\tT-1\nin\tO\nthe\tO\nDutch\tO\nfirst\tO\ndivision\tO\non\tO\nThursday\tO\n.\tO\n\nPhilip\tO\nCocu\tO\nscored\tO\ntwice\tO\nin\tO\nthe\tO\nsecond\tO\nhalf\tO\nto\tO\nspur\tT-1\nPSV\tB-ORG\nEindhoven\tI-ORG\nto\tO\na\tO\n4-1\tO\naway\tO\nwin\tO\nover\tO\nNEC\tT-0\nNijmegen\tT-0\nin\tO\nthe\tO\nDutch\tO\nfirst\tO\ndivision\tO\non\tO\nThursday\tO\n.\tO\n\nPhilip\tT-0\nCocu\tT-0\nscored\tT-1\ntwice\tO\nin\tO\nthe\tO\nsecond\tO\nhalf\tO\nto\tO\nspur\tO\nPSV\tO\nEindhoven\tO\nto\tO\na\tO\n4-1\tO\naway\tO\nwin\tO\nover\tO\nNEC\tB-ORG\nNijmegen\tI-ORG\nin\tO\nthe\tO\nDutch\tO\nfirst\tO\ndivision\tO\non\tO\nThursday\tO\n.\tO\n\nPhilip\tO\nCocu\tO\nscored\tT-1\ntwice\tT-1\nin\tO\nthe\tO\nsecond\tO\nhalf\tO\nto\tO\nspur\tO\nPSV\tO\nEindhoven\tO\nto\tO\na\tO\n4-1\tO\naway\tO\nwin\tO\nover\tO\nNEC\tO\nNijmegen\tT-0\nin\tO\nthe\tO\nDutch\tB-MISC\nfirst\tT-2\ndivision\tT-2\non\tO\nThursday\tO\n.\tO\n\nArthur\tB-PER\nNuman\tI-PER\nand\tO\nLuc\tT-0\nNilis\tT-0\n,\tO\nDutch\tO\ntop\tO\nscorer\tO\nlast\tO\nseason\tO\n,\tO\nwere\tT-2\nPSV\tT-1\n's\tO\nother\tO\nmarksmen\tT-3\n.\tO\n\nArthur\tT-1\nNuman\tT-1\nand\tO\nLuc\tB-PER\nNilis\tI-PER\n,\tO\nDutch\tO\ntop\tO\nscorer\tT-0\nlast\tO\nseason\tO\n,\tO\nwere\tT-2\nPSV\tT-3\n's\tT-3\nother\tT-3\nmarksmen\tT-3\n.\tT-3\n\nArthur\tT-2\nNuman\tT-2\nand\tO\nLuc\tT-3\nNilis\tT-3\n,\tO\nDutch\tB-MISC\ntop\tT-0\nscorer\tT-0\nlast\tO\nseason\tT-1\n,\tO\nwere\tO\nPSV\tO\n's\tO\nother\tO\nmarksmen\tO\n.\tO\n\nArthur\tT-1\nNuman\tT-1\nand\tO\nLuc\tT-2\nNilis\tT-2\n,\tO\nDutch\tT-0\ntop\tT-0\nscorer\tT-0\nlast\tO\nseason\tO\n,\tO\nwere\tO\nPSV\tB-ORG\n's\tO\nother\tO\nmarksmen\tT-3\n.\tO\n\nAjax\tB-ORG\nAmsterdam\tI-ORG\nopened\tO\ntheir\tT-0\ntitle\tT-0\ndefence\tT-0\nwith\tO\na\tO\n1-0\tO\nwin\tO\nover\tO\nNAC\tO\nBreda\tO\non\tO\nWednesday\tO\n.\tO\n\nAjax\tO\nAmsterdam\tO\nopened\tT-0\ntheir\tO\ntitle\tO\ndefence\tO\nwith\tO\na\tO\n1-0\tO\nwin\tO\nover\tO\nNAC\tB-ORG\nBreda\tI-ORG\non\tT-1\nWednesday\tT-1\n.\tO\n\nSOCCER\tT-0\n-\tO\nDUTCH\tB-MISC\nFIRST\tO\nDIVISION\tT-1\nSUMMARY\tO\n.\tO\n\nDutch\tB-MISC\nfirst\tT-0\ndivision\tT-0\nmatch\tT-0\n:\tO\n\nNEC\tB-ORG\nNijmegen\tI-ORG\n1\tO\n(\tO\nVan\tO\nEykeren\tO\n15th\tO\n)\tO\nPSV\tO\nEindhoven\tT-0\n4\tO\n(\tO\nNuman\tO\n11th\tO\n,\tO\n\nNEC\tO\nNijmegen\tT-0\n1\tO\n(\tO\nVan\tO\nEykeren\tO\n15th\tO\n)\tO\nPSV\tB-ORG\nEindhoven\tI-ORG\n4\tO\n(\tO\nNuman\tO\n11th\tO\n,\tO\n\nNilis\tT-0\n42nd\tO\n,\tO\nCocu\tB-PER\n54th\tT-1\n,\tT-1\n67th\tT-1\n)\tO\n.\tO\n\nSOCCER\tT-1\n-\tO\nDUTCH\tB-MISC\nFIRST\tO\nDIVISION\tO\nRESULT\tT-0\n.\tO\n\nResult\tT-0\nof\tO\na\tO\nDutch\tB-MISC\nfirst\tO\n\nNEC\tB-ORG\nNijmegen\tI-ORG\n1\tO\nPSV\tT-0\nEindhoven\tO\n4\tO\n\nSOCCER\tO\n-\tO\nSHARPSHOOTER\tT-1\nKNUP\tB-PER\nBACK\tT-0\nIN\tO\nSWISS\tO\nSQUAD\tO\n.\tO\n\nSOCCER\tO\n-\tO\nSHARPSHOOTER\tT-1\nKNUP\tO\nBACK\tT-0\nIN\tO\nSWISS\tB-MISC\nSQUAD\tO\n.\tO\n\nGalatasaray\tB-ORG\nstriker\tO\nAdrian\tO\nKnup\tO\n,\tO\nscorer\tO\nof\tO\n26\tO\ngoals\tO\nin\tO\n45\tO\ninternationals\tO\n,\tO\nhas\tO\nbeen\tO\nrecalled\tO\nby\tO\nSwitzerland\tT-1\nfor\tO\nthe\tO\nWorld\tT-0\nCup\tT-0\nqualifier\tO\nagainst\tO\nAzerbaijan\tO\nin\tO\nBaku\tO\non\tO\nAugust\tO\n31\tO\n.\tO\n\nGalatasaray\tO\nstriker\tO\nAdrian\tB-PER\nKnup\tI-PER\n,\tO\nscorer\tT-4\nof\tO\n26\tO\ngoals\tT-0\nin\tO\n45\tO\ninternationals\tO\n,\tO\nhas\tT-5\nbeen\tT-5\nrecalled\tT-5\nby\tO\nSwitzerland\tT-2\nfor\tO\nthe\tO\nWorld\tT-3\nCup\tT-3\nqualifier\tO\nagainst\tO\nAzerbaijan\tO\nin\tO\nBaku\tO\non\tO\nAugust\tO\n31\tO\n.\tO\n\nGalatasaray\tO\nstriker\tO\nAdrian\tO\nKnup\tO\n,\tO\nscorer\tO\nof\tO\n26\tO\ngoals\tO\nin\tO\n45\tO\ninternationals\tT-2\n,\tO\nhas\tO\nbeen\tO\nrecalled\tT-0\nby\tO\nSwitzerland\tB-LOC\nfor\tO\nthe\tO\nWorld\tT-1\nCup\tT-1\nqualifier\tT-1\nagainst\tO\nAzerbaijan\tO\nin\tO\nBaku\tO\non\tO\nAugust\tO\n31\tO\n.\tO\n\nGalatasaray\tT-0\nstriker\tT-0\nAdrian\tT-1\nKnup\tT-1\n,\tO\nscorer\tO\nof\tO\n26\tO\ngoals\tO\nin\tO\n45\tO\ninternationals\tO\n,\tO\nhas\tO\nbeen\tO\nrecalled\tT-3\nby\tO\nSwitzerland\tO\nfor\tO\nthe\tO\nWorld\tB-MISC\nCup\tI-MISC\nqualifier\tT-4\nagainst\tO\nAzerbaijan\tO\nin\tO\nBaku\tT-2\non\tO\nAugust\tO\n31\tO\n.\tO\n\nGalatasaray\tO\nstriker\tT-1\nAdrian\tO\nKnup\tO\n,\tO\nscorer\tO\nof\tO\n26\tO\ngoals\tO\nin\tO\n45\tO\ninternationals\tO\n,\tO\nhas\tO\nbeen\tO\nrecalled\tO\nby\tO\nSwitzerland\tO\nfor\tO\nthe\tO\nWorld\tO\nCup\tO\nqualifier\tO\nagainst\tO\nAzerbaijan\tB-LOC\nin\tT-0\nBaku\tO\non\tO\nAugust\tO\n31\tO\n.\tO\n\nGalatasaray\tO\nstriker\tO\nAdrian\tT-0\nKnup\tT-0\n,\tO\nscorer\tO\nof\tO\n26\tO\ngoals\tO\nin\tO\n45\tO\ninternationals\tO\n,\tO\nhas\tO\nbeen\tO\nrecalled\tO\nby\tO\nSwitzerland\tT-1\nfor\tO\nthe\tO\nWorld\tT-2\nCup\tT-2\nqualifier\tO\nagainst\tO\nAzerbaijan\tO\nin\tO\nBaku\tB-LOC\non\tO\nAugust\tO\n31\tO\n.\tO\n\nKnup\tB-PER\nwas\tT-0\noverlooked\tT-2\nby\tO\nArtur\tT-3\nJorge\tT-3\nfor\tO\nthe\tO\nEuropean\tT-1\nchampionship\tO\nfinals\tO\nearlier\tO\nthis\tO\nyear\tO\n.\tO\n\nKnup\tT-1\nwas\tO\noverlooked\tO\nby\tO\nArtur\tT-2\nJorge\tT-2\nfor\tO\nthe\tO\nEuropean\tB-MISC\nchampionship\tT-0\nfinals\tO\nearlier\tO\nthis\tO\nyear\tO\n.\tO\n\nBut\tO\nnew\tO\ncoach\tO\nRolf\tB-PER\nFringer\tI-PER\nis\tO\nclearly\tO\na\tO\nKnup\tO\nfan\tO\nand\tO\nincluded\tT-0\nhim\tO\nin\tO\nhis\tO\n19-man\tO\nsquad\tO\non\tO\nThursday\tO\n.\tO\n\nBut\tO\nnew\tO\ncoach\tT-0\nRolf\tT-3\nFringer\tT-3\nis\tO\nclearly\tO\na\tO\nKnup\tB-PER\nfan\tT-1\nand\tO\nincluded\tO\nhim\tO\nin\tO\nhis\tO\n19-man\tO\nsquad\tT-2\non\tO\nThursday\tO\n.\tO\n\nSwitzerland\tB-LOC\nfailed\tT-1\nto\tO\nprogress\tT-2\nbeyond\tO\nthe\tO\nopening\tO\ngroup\tO\nphase\tT-3\nin\tO\nEuro\tT-0\n96\tT-0\n.\tO\n\nSwitzerland\tT-1\nfailed\tT-0\nto\tO\nprogress\tO\nbeyond\tO\nthe\tO\nopening\tO\ngroup\tO\nphase\tO\nin\tO\nEuro\tB-MISC\n96\tI-MISC\n.\tO\n\nGoalkeepers\tT-0\n-\tO\nMarco\tT-1\nPascolo\tO\n(\tO\nCagliari\tB-ORG\n)\tO\n,\tO\nPascal\tO\nZuberbuehler\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nGoalkeepers\tT-0\n-\tO\nMarco\tT-1\nPascolo\tT-1\n(\tO\nCagliari\tT-2\n)\tO\n,\tO\nPascal\tB-PER\nZuberbuehler\tI-PER\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nGoalkeepers\tO\n-\tO\nMarco\tT-0\nPascolo\tT-0\n(\tO\nCagliari\tT-2\n)\tO\n,\tO\nPascal\tT-1\nZuberbuehler\tT-1\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n.\tO\n\nDefenders\tT-1\n-\tO\nStephane\tB-PER\nHenchoz\tI-PER\n(\tO\nHamburg\tT-2\n)\tO\n,\tO\nMarc\tT-0\nHottiger\tT-0\n(\tO\nEverton\tT-3\n)\tO\n,\tO\nYvan\tO\nQuentin\tO\n(\tO\nSion\tT-4\n)\tO\n,\tO\nRamon\tO\nVega\tO\n(\tO\nCagliari\tT-5\n)\tO\nRaphael\tO\nWicky\tO\n(\tO\nSion\tT-6\n)\tO\n.\tO\n\nDefenders\tO\n-\tO\nStephane\tT-0\nHenchoz\tT-0\n(\tO\nHamburg\tB-ORG\n)\tO\n,\tO\nMarc\tT-1\nHottiger\tT-1\n(\tO\nEverton\tT-5\n)\tO\n,\tO\nYvan\tT-2\nQuentin\tT-2\n(\tT-2\nSion\tT-6\n)\tO\n,\tO\nRamon\tT-3\nVega\tT-3\n(\tO\nCagliari\tT-7\n)\tO\nRaphael\tT-4\nWicky\tT-4\n(\tO\nSion\tO\n)\tO\n.\tO\n\nDefenders\tT-0\n-\tO\nStephane\tO\nHenchoz\tO\n(\tO\nHamburg\tO\n)\tO\n,\tO\nMarc\tB-PER\nHottiger\tI-PER\n(\tO\nEverton\tT-1\n)\tO\n,\tO\nYvan\tO\nQuentin\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nRamon\tO\nVega\tO\n(\tO\nCagliari\tO\n)\tO\nRaphael\tO\nWicky\tO\n(\tO\nSion\tO\n)\tO\n.\tO\n\nDefenders\tO\n-\tO\nStephane\tT-0\nHenchoz\tT-0\n(\tO\nHamburg\tO\n)\tO\n,\tO\nMarc\tO\nHottiger\tO\n(\tO\nEverton\tB-ORG\n)\tO\n,\tO\nYvan\tO\nQuentin\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nRamon\tO\nVega\tO\n(\tO\nCagliari\tO\n)\tO\nRaphael\tO\nWicky\tO\n(\tO\nSion\tO\n)\tO\n.\tO\n\nDefenders\tT-0\n-\tO\nStephane\tT-2\nHenchoz\tT-2\n(\tO\nHamburg\tO\n)\tO\n,\tO\nMarc\tT-3\nHottiger\tT-3\n(\tO\nEverton\tO\n)\tO\n,\tO\nYvan\tB-PER\nQuentin\tI-PER\n(\tO\nSion\tT-1\n)\tO\n,\tO\nRamon\tT-4\nVega\tT-4\n(\tO\nCagliari\tO\n)\tO\nRaphael\tT-5\nWicky\tT-5\n(\tO\nSion\tO\n)\tO\n.\tO\n\nDefenders\tT-0\n-\tO\nStephane\tO\nHenchoz\tO\n(\tO\nHamburg\tO\n)\tO\n,\tO\nMarc\tO\nHottiger\tO\n(\tO\nEverton\tO\n)\tO\n,\tO\nYvan\tT-1\nQuentin\tT-1\n(\tO\nSion\tB-ORG\n)\tO\n,\tO\nRamon\tO\nVega\tO\n(\tO\nCagliari\tO\n)\tO\nRaphael\tO\nWicky\tO\n(\tO\nSion\tO\n)\tO\n.\tO\n\nDefenders\tT-1\n-\tO\nStephane\tT-2\nHenchoz\tT-2\n(\tO\nHamburg\tO\n)\tO\n,\tO\nMarc\tT-3\nHottiger\tT-3\n(\tO\nEverton\tO\n)\tO\n,\tO\nYvan\tT-4\nQuentin\tT-4\n(\tO\nSion\tO\n)\tO\n,\tO\nRamon\tB-PER\nVega\tI-PER\n(\tO\nCagliari\tT-0\n)\tO\nRaphael\tO\nWicky\tO\n(\tO\nSion\tO\n)\tO\n.\tO\n\nDefenders\tO\n-\tO\nStephane\tO\nHenchoz\tO\n(\tO\nHamburg\tO\n)\tO\n,\tO\nMarc\tO\nHottiger\tO\n(\tO\nEverton\tO\n)\tO\n,\tO\nYvan\tO\nQuentin\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nRamon\tT-0\nVega\tT-0\n(\tO\nCagliari\tB-ORG\n)\tO\nRaphael\tT-1\nWicky\tT-1\n(\tT-1\nSion\tT-1\n)\tT-1\n.\tT-1\n\nDefenders\tT-1\n-\tO\nStephane\tT-0\nHenchoz\tT-0\n(\tO\nHamburg\tO\n)\tO\n,\tO\nMarc\tO\nHottiger\tO\n(\tO\nEverton\tO\n)\tO\n,\tO\nYvan\tO\nQuentin\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nRamon\tO\nVega\tO\n(\tO\nCagliari\tO\n)\tO\nRaphael\tT-2\nWicky\tO\n(\tO\nSion\tB-ORG\n)\tO\n.\tO\n\nMidfielders\tT-0\n-\tO\nAlexandre\tB-PER\nComisetti\tI-PER\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tO\nEsposito\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tT-0\n-\tO\nAlexandre\tT-1\nComisetti\tT-1\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n,\tO\nAntonio\tO\nEsposito\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tT-1\n-\tO\nAlexandre\tO\nComisetti\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tB-PER\nEsposito\tI-PER\n(\tO\nGrasshoppers\tT-0\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tT-0\n-\tO\nAlexandre\tO\nComisetti\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tT-1\nEsposito\tT-1\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tT-0\n-\tO\nAlexandre\tT-2\nComisetti\tT-2\n(\tO\nGrasshoppers\tT-9\n)\tO\n,\tO\nAntonio\tT-3\nEsposito\tT-3\n(\tO\nGrasshoppers\tT-10\n)\tO\n,\tO\nSebastien\tB-PER\nFournier\tI-PER\n(\tO\nStuttgart\tT-1\n)\tO\n,\tO\nChristophe\tT-4\nOhrel\tT-4\n(\tO\nLausanne\tT-11\n)\tO\n,\tO\nPatrick\tT-5\nSylvestre\tT-5\n(\tO\nSion\tT-12\n)\tO\n,\tO\nDavid\tT-6\nSesa\tT-6\n(\tO\nServette\tT-13\n)\tO\n,\tO\nCiriaco\tT-7\nSforza\tT-7\n(\tO\nInter\tT-14\nMilan\tT-14\n)\tO\nMurat\tT-8\nYakin\tT-8\n(\tO\nGrasshoppers\tT-15\n)\tO\n.\tO\n\nMidfielders\tT-1\n-\tO\nAlexandre\tO\nComisetti\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tO\nEsposito\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tT-0\nFournier\tT-0\n(\tO\nStuttgart\tB-LOC\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tO\n-\tO\nAlexandre\tT-0\nComisetti\tT-0\n(\tO\nGrasshoppers\tT-7\n)\tO\n,\tO\nAntonio\tT-1\nEsposito\tT-1\n(\tO\nGrasshoppers\tT-8\n)\tO\n,\tO\nSebastien\tT-2\nFournier\tT-2\n(\tO\nStuttgart\tT-9\n)\tO\n,\tO\nChristophe\tB-PER\nOhrel\tI-PER\n(\tO\nLausanne\tT-10\n)\tO\n,\tO\nPatrick\tT-3\nSylvestre\tT-3\n(\tO\nSion\tT-11\n)\tO\n,\tO\nDavid\tT-4\nSesa\tT-4\n(\tO\nServette\tT-12\n)\tO\n,\tO\nCiriaco\tT-5\nSforza\tT-5\n(\tO\nInter\tT-13\nMilan\tT-13\n)\tO\nMurat\tT-6\nYakin\tT-6\n(\tO\nGrasshoppers\tT-14\n)\tO\n.\tO\n\nMidfielders\tT-0\n-\tO\nAlexandre\tO\nComisetti\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tO\nEsposito\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tB-LOC\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tT-1\n-\tO\nAlexandre\tO\nComisetti\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tO\nEsposito\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tT-0\nSylvestre\tT-0\n(\tO\nSion\tB-ORG\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tT-0\n-\tO\nAlexandre\tT-1\nComisetti\tT-1\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tT-2\nEsposito\tT-2\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tB-PER\nSesa\tI-PER\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tO\n-\tO\nAlexandre\tT-0\nComisetti\tT-0\n(\tO\nGrasshoppers\tT-8\n)\tO\n,\tO\nAntonio\tT-1\nEsposito\tT-1\n(\tO\nGrasshoppers\tT-9\n)\tO\n,\tO\nSebastien\tT-2\nFournier\tT-2\n(\tO\nStuttgart\tT-10\n)\tO\n,\tO\nChristophe\tT-3\nOhrel\tT-3\n(\tO\nLausanne\tT-11\n)\tO\n,\tO\nPatrick\tT-4\nSylvestre\tT-4\n(\tO\nSion\tT-12\n)\tO\n,\tO\nDavid\tT-5\nSesa\tT-5\n(\tO\nServette\tB-ORG\n)\tO\n,\tO\nCiriaco\tT-6\nSforza\tT-6\n(\tO\nInter\tT-14\nMilan\tT-14\n)\tO\nMurat\tT-7\nYakin\tT-7\n(\tO\nGrasshoppers\tO\n)\tO\n.\tT-13\n\nMidfielders\tT-0\n-\tO\nAlexandre\tO\nComisetti\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tO\nEsposito\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tB-PER\nSforza\tI-PER\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tT-1\n-\tO\nAlexandre\tO\nComisetti\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tO\nEsposito\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tT-0\nSforza\tT-0\n(\tO\nInter\tB-ORG\nMilan\tI-ORG\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tT-0\n-\tO\nAlexandre\tO\nComisetti\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tO\nEsposito\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tB-PER\nYakin\tI-PER\n(\tO\nGrasshoppers\tO\n)\tO\n.\tO\n\nMidfielders\tT-0\n-\tO\nAlexandre\tO\nComisetti\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAntonio\tO\nEsposito\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nSebastien\tO\nFournier\tO\n(\tO\nStuttgart\tO\n)\tO\n,\tO\nChristophe\tO\nOhrel\tO\n(\tO\nLausanne\tO\n)\tO\n,\tO\nPatrick\tO\nSylvestre\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nDavid\tO\nSesa\tO\n(\tO\nServette\tO\n)\tO\n,\tO\nCiriaco\tO\nSforza\tO\n(\tO\nInter\tO\nMilan\tO\n)\tO\nMurat\tO\nYakin\tO\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n.\tO\n\nStrikers\tO\n-\tO\nKubilay\tB-PER\nTurkyilmaz\tI-PER\n(\tO\nGrasshoppers\tT-1\n)\tO\n,\tO\nAdrian\tT-0\nKnup\tT-0\n(\tO\nGalatasaray\tO\n)\tO\n,\tO\nChristophe\tO\nBonvin\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nStephane\tO\nChapuisat\tO\n(\tO\nBorussia\tO\nDortmund\tO\n)\tO\n.\tO\n\nStrikers\tT-0\n-\tO\nKubilay\tO\nTurkyilmaz\tO\n(\tO\nGrasshoppers\tB-ORG\n)\tO\n,\tO\nAdrian\tO\nKnup\tO\n(\tO\nGalatasaray\tO\n)\tO\n,\tO\nChristophe\tO\nBonvin\tO\n(\tO\nSion\tO\n)\tO\n,\tO\nStephane\tO\nChapuisat\tO\n(\tO\nBorussia\tO\nDortmund\tO\n)\tO\n.\tO\n\nStrikers\tT-4\n-\tO\nKubilay\tO\nTurkyilmaz\tO\n(\tO\nGrasshoppers\tT-0\n)\tO\n,\tO\nAdrian\tB-PER\nKnup\tI-PER\n(\tO\nGalatasaray\tT-1\n)\tO\n,\tO\nChristophe\tO\nBonvin\tO\n(\tO\nSion\tT-2\n)\tO\n,\tO\nStephane\tO\nChapuisat\tO\n(\tO\nBorussia\tT-3\nDortmund\tO\n)\tO\n.\tO\n\nStrikers\tT-0\n-\tO\nKubilay\tO\nTurkyilmaz\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAdrian\tT-1\nKnup\tT-1\n(\tO\nGalatasaray\tB-ORG\n)\tO\n,\tO\nChristophe\tT-2\nBonvin\tT-2\n(\tO\nSion\tO\n)\tO\n,\tO\nStephane\tO\nChapuisat\tO\n(\tO\nBorussia\tO\nDortmund\tO\n)\tO\n.\tO\n\nStrikers\tT-1\n-\tO\nKubilay\tO\nTurkyilmaz\tO\n(\tO\nGrasshoppers\tO\n)\tO\n,\tO\nAdrian\tO\nKnup\tO\n(\tO\nGalatasaray\tO\n)\tO\n,\tO\nChristophe\tT-0\nBonvin\tT-0\n(\tO\nSion\tB-ORG\n)\tO\n,\tO\nStephane\tO\nChapuisat\tO\n(\tO\nBorussia\tO\nDortmund\tO\n)\tO\n.\tO\n\nStrikers\tT-0\n-\tO\nKubilay\tO\nTurkyilmaz\tO\n(\tO\nGrasshoppers\tT-1\n)\tO\n,\tO\nAdrian\tO\nKnup\tO\n(\tO\nGalatasaray\tT-2\n)\tO\n,\tO\nChristophe\tO\nBonvin\tO\n(\tO\nSion\tT-3\n)\tO\n,\tO\nStephane\tB-PER\nChapuisat\tI-PER\n(\tO\nBorussia\tT-4\nDortmund\tT-4\n)\tO\n.\tO\n\nStrikers\tT-7\n-\tO\nKubilay\tT-0\nTurkyilmaz\tT-0\n(\tO\nGrasshoppers\tT-4\n)\tO\n,\tO\nAdrian\tT-1\nKnup\tT-1\n(\tO\nGalatasaray\tT-5\n)\tO\n,\tO\nChristophe\tT-2\nBonvin\tT-2\n(\tO\nSion\tT-6\n)\tO\n,\tO\nStephane\tT-3\nChapuisat\tT-3\n(\tO\nBorussia\tB-ORG\nDortmund\tI-ORG\n)\tO\n.\tO\n\nSpectators\tT-1\nat\tO\nFriday\tO\n's\tO\nBrussels\tB-LOC\ngrand\tT-0\nprix\tT-0\nmeeting\tO\nhave\tO\nan\tO\nextra\tO\nincentive\tO\nto\tO\ncheer\tO\non\tO\nthe\tO\nathletes\tO\nto\tO\nworld\tT-2\nrecord\tT-2\nperformances\tT-2\n--\tO\na\tO\nfree\tO\nglass\tO\nof\tO\nbeer\tO\n.\tO\n\nA\tO\nBelgian\tB-MISC\nbrewery\tT-1\nhas\tT-0\noffered\tT-0\nto\tO\npay\tT-2\nfor\tO\na\tO\nfree\tO\nround\tO\nof\tO\ndrinks\tO\nfor\tO\nall\tO\nof\tO\nthe\tO\n40,000\tO\ncrowd\tO\nif\tO\na\tO\nworld\tO\nrecord\tO\ngoes\tO\nat\tO\nthe\tO\nmeeting\tO\n,\tO\norganisers\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nGOLF\tO\n-\tO\nGERMAN\tB-MISC\nOPEN\tI-MISC\nFIRST\tT-0\nROUND\tT-0\nSCORES\tT-0\n.\tO\n\nSTUTTGART\tB-LOC\n,\tO\nGermany\tT-0\n1996-08-22\tO\n\nscores\tO\nin\tO\nthe\tO\nGerman\tB-MISC\nOpen\tI-MISC\ngolf\tO\nchampionship\tT-0\non\tO\nThursday\tO\n(\tO\nBritain\tO\n\nscores\tO\nin\tO\nthe\tO\nGerman\tT-1\nOpen\tT-1\ngolf\tO\nchampionship\tO\non\tO\nThursday\tT-0\n(\tO\nBritain\tB-LOC\n\n64\tO\nDavid\tO\nJ.\tO\nRussell\tO\n,\tO\nMichael\tB-PER\nCampbell\tI-PER\n(\tO\nNew\tO\nZealand\tO\n)\tO\n,\tO\nIan\tT-0\n\n64\tO\nDavid\tO\nJ.\tO\nRussell\tO\n,\tO\nMichael\tT-0\nCampbell\tT-0\n(\tO\nNew\tB-LOC\nZealand\tI-LOC\n)\tO\n,\tO\nIan\tO\n\n64\tO\nDavid\tT-0\nJ.\tT-0\nRussell\tT-0\n,\tO\nMichael\tT-1\nCampbell\tT-1\n(\tT-1\nNew\tT-1\nZealand\tT-1\n)\tT-1\n,\tO\nIan\tB-PER\n\nWoosnam\tB-PER\n,\tO\nBernhard\tT-0\nLanger\tO\n(\tO\nGermany\tO\n)\tO\n,\tO\nRonan\tO\nRafferty\tO\n,\tO\nMats\tT-0\n\nWoosnam\tT-0\n,\tO\nBernhard\tB-PER\nLanger\tI-PER\n(\tT-1\nGermany\tT-1\n)\tT-1\n,\tO\nRonan\tO\nRafferty\tO\n,\tO\nMats\tO\n\nWoosnam\tT-0\n,\tO\nBernhard\tO\nLanger\tT-1\n(\tO\nGermany\tB-LOC\n)\tO\n,\tO\nRonan\tO\nRafferty\tO\n,\tO\nMats\tO\n\nWoosnam\tT-0\n,\tO\nBernhard\tT-1\nLanger\tT-1\n(\tO\nGermany\tT-2\n)\tO\n,\tO\nRonan\tB-PER\nRafferty\tI-PER\n,\tO\nMats\tO\n\nWoosnam\tT-1\n,\tO\nBernhard\tO\nLanger\tO\n(\tO\nGermany\tT-0\n)\tO\n,\tO\nRonan\tT-2\nRafferty\tT-2\n,\tO\nMats\tB-PER\n\nLanner\tB-PER\n(\tO\nSweden\tT-1\n)\tO\n,\tO\nWayne\tT-0\nRiley\tT-0\n(\tO\nAustralia\tO\n)\tO\n\nLanner\tT-0\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nWayne\tT-1\nRiley\tT-1\n(\tO\nAustralia\tO\n)\tO\n\nLanner\tO\n(\tO\nSweden\tO\n)\tO\n,\tO\nWayne\tB-PER\nRiley\tI-PER\n(\tO\nAustralia\tT-0\n)\tO\n\nLanner\tO\n(\tO\nSweden\tT-0\n)\tO\n,\tO\nWayne\tT-1\nRiley\tT-1\n(\tO\nAustralia\tB-LOC\n)\tO\n\n65\tO\nEamonn\tO\nDarcy\tO\n(\tO\nIreland\tB-LOC\n)\tO\n,\tO\nPer\tT-0\nNyman\tT-0\n(\tO\nSweden\tO\n)\tO\n,\tO\nRussell\tT-1\nClaydon\tT-1\n,\tO\n\n65\tO\nEamonn\tO\nDarcy\tO\n(\tO\nIreland\tO\n)\tO\n,\tO\nPer\tB-PER\nNyman\tI-PER\n(\tO\nSweden\tT-0\n)\tO\n,\tO\nRussell\tT-1\nClaydon\tT-1\n,\tO\n\n65\tO\nEamonn\tO\nDarcy\tO\n(\tO\nIreland\tT-0\n)\tO\n,\tO\nPer\tO\nNyman\tO\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nRussell\tO\nClaydon\tO\n,\tO\n\n65\tO\nEamonn\tO\nDarcy\tO\n(\tO\nIreland\tO\n)\tO\n,\tO\nPer\tT-1\nNyman\tT-1\n(\tO\nSweden\tT-0\n)\tO\n,\tO\nRussell\tB-PER\nClaydon\tI-PER\n,\tO\n\nMark\tB-PER\nRoe\tI-PER\n,\tO\nRetief\tT-0\nGoosen\tT-0\n(\tO\nSouth\tO\nAfrica\tO\n)\tO\n,\tO\nCarl\tT-1\nSuneson\tT-1\n\nMark\tT-0\nRoe\tT-0\n,\tO\nRetief\tB-PER\nGoosen\tI-PER\n(\tO\nSouth\tO\nAfrica\tO\n)\tO\n,\tO\nCarl\tT-1\nSuneson\tT-1\n\nMark\tT-0\nRoe\tT-0\n,\tO\nRetief\tT-1\nGoosen\tT-1\n(\tO\nSouth\tT-2\nAfrica\tT-2\n)\tO\n,\tO\nCarl\tB-PER\nSuneson\tI-PER\n\n66\tO\nStephen\tB-PER\nField\tI-PER\n,\tO\nPaul\tT-0\nLawrie\tT-0\n,\tO\nIan\tT-1\nPyman\tT-1\n,\tO\nMax\tT-2\nAnglert\tT-2\n\n66\tO\nStephen\tT-0\nField\tO\n,\tO\nPaul\tB-PER\nLawrie\tI-PER\n,\tO\nIan\tO\nPyman\tO\n,\tO\nMax\tO\nAnglert\tO\n\n66\tO\nStephen\tT-0\nField\tT-0\n,\tO\nPaul\tT-1\nLawrie\tT-1\n,\tO\nIan\tB-PER\nPyman\tI-PER\n,\tO\nMax\tT-2\nAnglert\tT-2\n\n66\tO\nStephen\tO\nField\tO\n,\tO\nPaul\tT-0\nLawrie\tT-0\n,\tO\nIan\tT-1\nPyman\tT-1\n,\tO\nMax\tB-PER\nAnglert\tI-PER\n\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nMiles\tO\nTunnicliff\tO\n,\tO\nChristian\tT-0\nCevaer\tT-0\n(\tO\nFrance\tT-1\n)\tO\n,\tO\n\n(\tO\nSweden\tT-0\n)\tO\n,\tO\nMiles\tB-PER\nTunnicliff\tI-PER\n,\tO\nChristian\tO\nCevaer\tO\n(\tO\nFrance\tO\n)\tO\n,\tO\n\n(\tO\nSweden\tT-1\n)\tO\n,\tO\nMiles\tT-0\nTunnicliff\tT-0\n,\tO\nChristian\tT-2\nCevaer\tT-2\n(\tO\nFrance\tB-LOC\n)\tO\n,\tO\n\nDes\tB-PER\nSmyth\tI-PER\n(\tO\nIreland\tO\n)\tO\n,\tO\nDavid\tT-0\nCarter\tT-0\n,\tO\nLee\tO\nWestwood\tO\n,\tO\nGreg\tO\n\nDes\tT-0\nSmyth\tT-0\n(\tO\nIreland\tB-LOC\n)\tO\n,\tO\nDavid\tO\nCarter\tO\n,\tO\nLee\tO\nWestwood\tO\n,\tO\nGreg\tO\n\nDes\tT-0\nSmyth\tT-0\n(\tT-0\nIreland\tT-0\n)\tT-0\n,\tO\nDavid\tB-PER\nCarter\tI-PER\n,\tO\nLee\tT-1\nWestwood\tT-1\n,\tO\nGreg\tO\n\nDes\tO\nSmyth\tO\n(\tO\nIreland\tO\n)\tO\n,\tO\nDavid\tO\nCarter\tO\n,\tO\nLee\tB-PER\nWestwood\tI-PER\n,\tO\nGreg\tT-0\n\nDes\tT-0\nSmyth\tT-0\n(\tO\nIreland\tT-2\n)\tO\n,\tO\nDavid\tT-1\nCarter\tT-1\n,\tO\nLee\tO\nWestwood\tO\n,\tO\nGreg\tB-PER\n\nChalmers\tB-PER\n(\tO\nAustralia\tT-0\n)\tO\n,\tO\nMiguel\tO\nAngel\tO\nMartin\tO\n(\tO\nSpain\tT-1\n)\tO\n,\tO\n\nChalmers\tT-0\n(\tO\nAustralia\tB-LOC\n)\tO\n,\tO\nMiguel\tO\nAngel\tO\nMartin\tO\n(\tO\nSpain\tO\n)\tO\n,\tO\n\nChalmers\tO\n(\tO\nAustralia\tO\n)\tO\n,\tO\nMiguel\tB-PER\nAngel\tI-PER\nMartin\tI-PER\n(\tO\nSpain\tT-0\n)\tO\n,\tO\n\nChalmers\tO\n(\tO\nAustralia\tO\n)\tO\n,\tO\nMiguel\tT-0\nAngel\tT-0\nMartin\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\n\nThomas\tB-PER\nBjorn\tI-PER\n(\tO\nDenmark\tT-0\n)\tO\n,\tO\nFernando\tO\nRoca\tO\n(\tO\nSpain\tO\n)\tO\n,\tO\nDerrick\tO\n\nThomas\tT-1\nBjorn\tT-1\n(\tO\nDenmark\tB-LOC\n)\tO\n,\tO\nFernando\tO\nRoca\tO\n(\tO\nSpain\tT-0\n)\tO\n,\tO\nDerrick\tO\n\nThomas\tT-0\nBjorn\tT-0\n(\tO\nDenmark\tO\n)\tO\n,\tO\nFernando\tO\nRoca\tO\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\nDerrick\tO\n\nThomas\tO\nBjorn\tO\n(\tO\nDenmark\tO\n)\tO\n,\tO\nFernando\tT-0\nRoca\tT-0\n(\tO\nSpain\tO\n)\tO\n,\tO\nDerrick\tB-PER\n\n67\tO\nJeff\tB-PER\nHawksworth\tI-PER\n,\tO\nPadraig\tT-2\nHarrington\tT-3\n(\tO\nIreland\tT-0\n)\tO\n,\tO\nMichael\tT-1\n\n67\tO\nJeff\tO\nHawksworth\tO\n,\tO\nPadraig\tB-PER\nHarrington\tI-PER\n(\tO\nIreland\tO\n)\tO\n,\tO\nMichael\tT-0\n\n67\tO\nJeff\tT-0\nHawksworth\tT-0\n,\tO\nPadraig\tO\nHarrington\tO\n(\tO\nIreland\tB-LOC\n)\tO\n,\tO\nMichael\tT-1\n\nWelch\tB-PER\n,\tO\nThomas\tO\nGogele\tT-1\n(\tO\nGermany\tT-0\n)\tO\n,\tO\nPaul\tO\nMcGinley\tO\n(\tO\nIreland\tO\n)\tO\n,\tO\n\nWelch\tT-3\n,\tO\nThomas\tB-PER\nGogele\tI-PER\n(\tO\nGermany\tT-1\n)\tO\n,\tO\nPaul\tT-0\nMcGinley\tT-0\n(\tO\nIreland\tT-2\n)\tO\n,\tO\n\nWelch\tT-0\n,\tO\nThomas\tO\nGogele\tO\n(\tO\nGermany\tB-LOC\n)\tO\n,\tO\nPaul\tT-1\nMcGinley\tT-1\n(\tO\nIreland\tT-2\n)\tO\n,\tO\n\nWelch\tO\n,\tO\nThomas\tT-0\nGogele\tT-0\n(\tO\nGermany\tO\n)\tO\n,\tO\nPaul\tB-PER\nMcGinley\tI-PER\n(\tO\nIreland\tO\n)\tO\n,\tO\n\nWelch\tO\n,\tO\nThomas\tT-0\nGogele\tT-0\n(\tO\nGermany\tT-1\n)\tO\n,\tO\nPaul\tO\nMcGinley\tO\n(\tO\nIreland\tB-LOC\n)\tO\n,\tO\n\nGary\tB-PER\nOrr\tI-PER\n,\tO\nJose-Maria\tT-0\nCanizares\tT-0\n(\tO\nSpain\tT-1\n)\tO\n,\tO\nMichael\tO\nJonzon\tO\n\nGary\tO\nOrr\tT-0\n,\tO\nJose-Maria\tB-PER\nCanizares\tI-PER\n(\tO\nSpain\tO\n)\tO\n,\tO\nMichael\tT-1\nJonzon\tT-2\n\nGary\tO\nOrr\tO\n,\tO\nJose-Maria\tT-0\nCanizares\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\nMichael\tO\nJonzon\tO\n\nGary\tT-0\nOrr\tT-0\n,\tO\nJose-Maria\tT-1\nCanizares\tT-1\n(\tO\nSpain\tO\n)\tO\n,\tO\nMichael\tB-PER\nJonzon\tI-PER\n\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nPaul\tT-0\nEales\tT-0\n,\tO\nDavid\tT-2\nWilliams\tO\n,\tO\nAndrew\tT-1\nColtart\tT-1\n,\tT-2\n\n(\tT-0\nSweden\tT-0\n)\tT-0\n,\tO\nPaul\tT-1\nEales\tT-1\n,\tO\nDavid\tB-PER\nWilliams\tI-PER\n,\tO\nAndrew\tO\nColtart\tO\n,\tO\n\n(\tO\nSweden\tO\n)\tO\n,\tO\nPaul\tT-0\nEales\tT-0\n,\tO\nDavid\tO\nWilliams\tO\n,\tO\nAndrew\tB-PER\nColtart\tI-PER\n,\tO\n\nJonathan\tB-PER\nLomas\tI-PER\n,\tO\nJose\tO\nRivero\tO\n(\tO\nSpain\tT-0\n)\tO\n,\tO\nRobert\tO\nKarlsson\tO\n\nJonathan\tT-0\nLomas\tT-0\n,\tO\nJose\tB-PER\nRivero\tI-PER\n(\tO\nSpain\tT-1\n)\tO\n,\tO\nRobert\tO\nKarlsson\tO\n\nJonathan\tT-0\nLomas\tT-0\n,\tO\nJose\tT-1\nRivero\tT-1\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\nRobert\tT-2\nKarlsson\tT-2\n\n(\tO\nSweden\tB-LOC\n)\tO\n,\tO\nMarcus\tT-1\nWills\tT-1\n,\tO\nPedro\tT-2\nLinhart\tT-2\n(\tT-0\nSpain\tT-0\n)\tT-0\n,\tO\nJamie\tT-3\n\n(\tO\nSweden\tO\n)\tO\n,\tO\nMarcus\tB-PER\nWills\tI-PER\n,\tO\nPedro\tT-0\nLinhart\tT-0\n(\tO\nSpain\tT-1\n)\tO\n,\tO\nJamie\tT-2\n\n(\tO\nSweden\tO\n)\tO\n,\tO\nMarcus\tO\nWills\tO\n,\tO\nPedro\tB-PER\nLinhart\tI-PER\n(\tO\nSpain\tT-1\n)\tO\n,\tO\nJamie\tT-0\n\n(\tO\nSweden\tT-0\n)\tO\n,\tO\nMarcus\tO\nWills\tO\n,\tO\nPedro\tO\nLinhart\tO\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\nJamie\tO\n\n(\tO\nSweden\tO\n)\tO\n,\tO\nMarcus\tO\nWills\tO\n,\tO\nPedro\tT-0\nLinhart\tT-0\n(\tO\nSpain\tT-1\n)\tO\n,\tO\nJamie\tB-PER\n\nSpence\tB-PER\n,\tO\nTerry\tT-0\nPrice\tT-0\n(\tO\nAustralia\tO\n)\tO\n,\tO\nJuan\tO\nCarlos\tO\nPinero\tO\n(\tO\nSpain\tO\n)\tO\n,\tO\n\nSpence\tT-2\n,\tO\nTerry\tB-PER\nPrice\tI-PER\n(\tO\nAustralia\tT-3\n)\tO\n,\tO\nJuan\tT-1\nCarlos\tT-1\nPinero\tT-1\n(\tO\nSpain\tO\n)\tO\n,\tO\n\nSpence\tT-1\n,\tO\nTerry\tT-2\nPrice\tT-2\n(\tO\nAustralia\tB-LOC\n)\tO\n,\tO\nJuan\tT-3\nCarlos\tT-3\nPinero\tT-3\n(\tO\nSpain\tT-0\n)\tO\n,\tO\n\nSpence\tO\n,\tO\nTerry\tO\nPrice\tO\n(\tO\nAustralia\tT-0\n)\tO\n,\tO\nJuan\tB-PER\nCarlos\tI-PER\nPinero\tI-PER\n(\tO\nSpain\tO\n)\tO\n,\tO\n\nSpence\tO\n,\tO\nTerry\tT-0\nPrice\tT-0\n(\tO\nAustralia\tO\n)\tO\n,\tO\nJuan\tT-1\nCarlos\tT-1\nPinero\tT-1\n(\tO\nSpain\tB-LOC\n)\tO\n,\tO\n\nSOCCER\tT-0\n-\tO\nUEFA\tB-ORG\nREWARDS\tT-1\nTHREE\tO\nCOUNTRIES\tO\nFOR\tO\nFAIR\tO\nPLAY\tO\n.\tO\n\nNorway\tB-LOC\n,\tO\nEngland\tT-1\nand\tT-1\nSweden\tT-1\nwere\tO\nrewarded\tO\nfor\tO\ntheir\tO\nfair\tO\nplay\tO\non\tO\nThursday\tO\nwith\tO\nan\tO\nadditional\tT-0\nplace\tO\nin\tO\nthe\tO\n1997-98\tO\nUEFA\tO\nCup\tO\ncompetition\tO\n.\tO\n\nNorway\tO\n,\tO\nEngland\tB-LOC\nand\tT-1\nSweden\tT-1\nwere\tO\nrewarded\tO\nfor\tO\ntheir\tO\nfair\tO\nplay\tO\non\tO\nThursday\tO\nwith\tO\nan\tO\nadditional\tO\nplace\tO\nin\tO\nthe\tO\n1997-98\tO\nUEFA\tO\nCup\tO\ncompetition\tO\n.\tO\n\nNorway\tO\n,\tO\nEngland\tO\nand\tO\nSweden\tB-LOC\nwere\tO\nrewarded\tT-2\nfor\tO\ntheir\tO\nfair\tO\nplay\tT-1\non\tO\nThursday\tO\nwith\tO\nan\tO\nadditional\tO\nplace\tO\nin\tO\nthe\tO\n1997-98\tO\nUEFA\tT-0\nCup\tT-0\ncompetition\tO\n.\tO\n\nNorway\tB-LOC\nheaded\tT-0\nthe\tO\nUEFA\tT-2\nFair\tO\nPlay\tO\nrankings\tT-1\nfor\tO\n1995-96\tO\nwith\tO\n8.62\tO\npoints\tO\n,\tO\nahead\tO\nof\tO\nEngland\tO\nwith\tO\n8.61\tO\nand\tO\nSweden\tO\n8.57\tO\n.\tO\n\nNorway\tT-1\nheaded\tO\nthe\tO\nUEFA\tB-MISC\nFair\tI-MISC\nPlay\tI-MISC\nrankings\tT-4\nfor\tO\n1995-96\tT-0\nwith\tO\n8.62\tO\npoints\tO\n,\tO\nahead\tO\nof\tO\nEngland\tT-2\nwith\tO\n8.61\tO\nand\tO\nSweden\tT-3\n8.57\tO\n.\tO\n\nNorway\tO\nheaded\tO\nthe\tO\nUEFA\tT-3\nFair\tT-3\nPlay\tT-3\nrankings\tT-3\nfor\tO\n1995-96\tT-1\nwith\tO\n8.62\tO\npoints\tO\n,\tO\nahead\tO\nof\tT-0\nEngland\tB-LOC\nwith\tO\n8.61\tT-2\nand\tO\nSweden\tO\n8.57\tO\n.\tO\n\nNorway\tO\nheaded\tO\nthe\tO\nUEFA\tO\nFair\tO\nPlay\tO\nrankings\tO\nfor\tO\n1995-96\tT-1\nwith\tO\n8.62\tO\npoints\tT-0\n,\tO\nahead\tO\nof\tO\nEngland\tO\nwith\tO\n8.61\tO\nand\tO\nSweden\tB-LOC\n8.57\tO\n.\tO\n\nNorway\tB-LOC\n8.62\tT-0\npoints\tT-0\n\n2.\tO\nEngland\tB-LOC\n8.61\tT-0\n\n3.\tO\nSweden\tB-LOC\n8.57\tT-0\n\n5.\tO\nWales\tB-LOC\n8.54\tT-0\n\n6.\tO\nEstonia\tB-LOC\n8.52\tT-0\n\n8.\tT-0\nBelarus\tB-LOC\n8.39\tT-1\n\n15.\tT-0\nMoldova\tB-LOC\n8.24\tT-0\n\n18.\tT-0\nLuxembourg\tB-LOC\n8.20\tT-1\n\n19.\tT-0\nFrance\tB-LOC\n8.18\tO\n\n20.\tO\nIsrael\tB-LOC\n8.17\tT-0\n\n25.\tO\nGeorgia\tB-LOC\n8.10\tT-0\n\n26.\tO\nUkraine\tB-LOC\n8.09\tT-0\n\n26.\tO\nSpain\tB-LOC\n8.09\tT-0\n\n26.\tO\nFinland\tB-LOC\n8.09\tT-0\n\n30.\tO\nLithuania\tB-LOC\n8.06\tT-0\n\n32.\tO\nRussia\tB-LOC\n8.03\tT-0\n\n36.\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n7.95\tT-0\n\n42.\tO\nSlovenia\tB-LOC\n7.77\tT-0\n\n43.\tO\nCroatia\tB-LOC\n7.75\tT-0\n\n45.\tO\nMalta\tB-LOC\n7.40\tT-0\n\nCRICKET\tT-1\n-\tO\nPOLICE\tO\nCOMMANDOS\tO\nON\tO\nHAND\tT-2\nFOR\tO\nAUSTRALIANS\tB-MISC\n'\tO\nFIRST\tT-0\nMATCH\tT-0\n.\tO\n\nArmed\tO\npolice\tO\ncommandos\tT-2\npatrolled\tO\nthe\tO\nground\tT-0\nwhen\tO\nAustralia\tB-LOC\nopened\tT-1\ntheir\tO\nshort\tO\ntour\tO\nof\tO\nSri\tT-3\nLanka\tT-3\nwith\tO\na\tO\nfive-run\tO\nwin\tO\nover\tO\nthe\tO\ncountry\tO\n's\tO\nyouth\tO\nteam\tO\non\tO\nThursday\tO\n.\tO\n\nArmed\tT-0\npolice\tT-0\ncommandos\tT-0\npatrolled\tT-2\nthe\tO\nground\tO\nwhen\tO\nAustralia\tO\nopened\tO\ntheir\tO\nshort\tO\ntour\tT-1\nof\tT-1\nSri\tB-LOC\nLanka\tI-LOC\nwith\tO\na\tO\nfive-run\tO\nwin\tO\nover\tO\nthe\tO\ncountry\tO\n's\tO\nyouth\tO\nteam\tO\non\tO\nThursday\tO\n.\tO\n\nAustralia\tB-LOC\n,\tO\nin\tT-2\nSri\tO\nLanka\tO\nfor\tO\na\tO\nlimited\tO\novers\tO\ntournament\tT-0\nwhich\tO\nalso\tO\nincludes\tT-1\nIndia\tO\nand\tO\nZimbabwe\tO\n,\tO\nhave\tO\nbeen\tO\npromised\tO\nthe\tO\npresence\tO\nof\tO\ncommandos\tO\n,\tO\nsniffer\tO\ndogs\tO\nand\tO\nplainclothes\tO\npolicemen\tO\nto\tO\nensure\tO\nthe\tO\ntournament\tO\nis\tO\ntrouble-free\tO\n.\tO\n\nAustralia\tO\n,\tO\nin\tT-0\nSri\tB-LOC\nLanka\tI-LOC\nfor\tO\na\tO\nlimited\tO\novers\tO\ntournament\tO\nwhich\tO\nalso\tO\nincludes\tO\nIndia\tO\nand\tO\nZimbabwe\tO\n,\tO\nhave\tO\nbeen\tO\npromised\tO\nthe\tO\npresence\tO\nof\tO\ncommandos\tO\n,\tO\nsniffer\tO\ndogs\tO\nand\tO\nplainclothes\tO\npolicemen\tO\nto\tO\nensure\tO\nthe\tO\ntournament\tO\nis\tO\ntrouble-free\tO\n.\tO\n\nAustralia\tO\n,\tO\nin\tO\nSri\tO\nLanka\tO\nfor\tO\na\tO\nlimited\tT-0\novers\tO\ntournament\tO\nwhich\tO\nalso\tO\nincludes\tO\nIndia\tB-LOC\nand\tO\nZimbabwe\tO\n,\tO\nhave\tO\nbeen\tO\npromised\tO\nthe\tO\npresence\tT-2\nof\tO\ncommandos\tO\n,\tO\nsniffer\tO\ndogs\tO\nand\tO\nplainclothes\tO\npolicemen\tT-1\nto\tO\nensure\tO\nthe\tO\ntournament\tO\nis\tO\ntrouble-free\tO\n.\tO\n\nAustralia\tT-1\n,\tO\nin\tO\nSri\tT-2\nLanka\tT-2\nfor\tO\na\tO\nlimited\tT-0\novers\tO\ntournament\tO\nwhich\tO\nalso\tO\nincludes\tO\nIndia\tO\nand\tO\nZimbabwe\tB-LOC\n,\tO\nhave\tO\nbeen\tO\npromised\tT-4\nthe\tO\npresence\tO\nof\tO\ncommandos\tT-3\n,\tO\nsniffer\tO\ndogs\tO\nand\tO\nplainclothes\tO\npolicemen\tO\nto\tO\nensure\tO\nthe\tO\ntournament\tO\nis\tO\ntrouble-free\tO\n.\tO\n\nThey\tO\nare\tO\nmaking\tO\ntheir\tO\nfirst\tO\nvisit\tO\nto\tO\nthe\tO\nisland\tO\nsince\tO\nboycotting\tO\na\tO\nWorld\tB-MISC\nCup\tI-MISC\nfixture\tT-0\nin\tO\nFebruary\tO\nbecause\tO\nof\tO\nfears\tO\nover\tO\nethnic\tO\nviolence\tO\n.\tO\n\nAustralia\tB-LOC\n,\tO\nbatting\tT-1\nfirst\tO\nin\tO\nThursday\tO\n's\tO\nthe\tO\nwarm-up\tT-0\nmatch\tT-0\n,\tO\nscored\tO\n251\tO\nfor\tO\nseven\tO\nfrom\tO\ntheir\tO\n50\tO\novers\tO\n.\tO\n\nRicky\tB-PER\nPonting\tI-PER\nled\tO\nthe\tO\nway\tO\nwith\tO\n100\tO\noff\tO\n119\tO\nballs\tT-0\nwith\tO\ntwo\tO\nsixes\tO\nand\tO\nnine\tO\nfours\tO\nbefore\tO\nretiring\tO\n.\tO\n\nAustralian\tB-MISC\ncoach\tT-3\nGeoff\tT-3\nMarsh\tO\nsaid\tT-1\nhe\tO\nwas\tO\nimpressed\tT-0\nwith\tO\nthe\tO\ncompetitiveness\tT-2\nof\tO\nthe\tO\nopposition\tO\n.\tO\n\nAustralian\tO\ncoach\tO\nGeoff\tB-PER\nMarsh\tI-PER\nsaid\tT-0\nhe\tO\nwas\tO\nimpressed\tT-1\nwith\tO\nthe\tO\ncompetitiveness\tO\nof\tO\nthe\tO\nopposition\tO\n.\tO\n\nONE\tO\nROMANIAN\tB-MISC\nDIES\tO\nIN\tO\nBUS\tO\nCRASH\tT-0\nIN\tO\nBULGARIA\tO\n.\tO\n\nONE\tO\nROMANIAN\tO\nDIES\tT-1\nIN\tO\nBUS\tO\nCRASH\tT-0\nIN\tO\nBULGARIA\tB-LOC\n.\tO\n\nOne\tT-0\nRomanian\tB-MISC\npassenger\tO\nwas\tO\nkilled\tT-2\n,\tO\nand\tO\n14\tO\nothers\tO\nwere\tO\ninjured\tT-1\non\tO\nThursday\tO\nwhen\tO\na\tO\nRomanian-registered\tO\nbus\tO\ncollided\tO\nwith\tO\na\tO\nBulgarian\tO\none\tO\nin\tO\nnorthern\tO\nBulgaria\tO\n,\tO\npolice\tO\nsaid\tT-3\n.\tO\n\nOne\tO\nRomanian\tT-0\npassenger\tT-0\nwas\tO\nkilled\tO\n,\tO\nand\tO\n14\tO\nothers\tO\nwere\tO\ninjured\tO\non\tO\nThursday\tO\nwhen\tO\na\tO\nRomanian-registered\tB-MISC\nbus\tT-1\ncollided\tO\nwith\tO\na\tO\nBulgarian\tO\none\tO\nin\tO\nnorthern\tO\nBulgaria\tO\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nOne\tO\nRomanian\tO\npassenger\tO\nwas\tO\nkilled\tT-2\n,\tO\nand\tO\n14\tO\nothers\tO\nwere\tO\ninjured\tT-3\non\tO\nThursday\tO\nwhen\tO\na\tO\nRomanian-registered\tO\nbus\tT-0\ncollided\tO\nwith\tO\na\tO\nBulgarian\tB-MISC\none\tO\nin\tO\nnorthern\tO\nBulgaria\tO\n,\tO\npolice\tT-1\nsaid\tO\n.\tO\n\nOne\tO\nRomanian\tO\npassenger\tO\nwas\tT-2\nkilled\tT-2\n,\tO\nand\tO\n14\tO\nothers\tO\nwere\tO\ninjured\tO\non\tO\nThursday\tO\nwhen\tO\na\tO\nRomanian-registered\tT-0\nbus\tT-0\ncollided\tO\nwith\tO\na\tO\nBulgarian\tT-1\none\tO\nin\tO\nnorthern\tO\nBulgaria\tB-LOC\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nThe\tT-1\ntwo\tT-1\nbuses\tT-1\ncollided\tO\nhead\tO\non\tO\nat\tO\n5\tO\no'clock\tO\nthis\tO\nmorning\tO\non\tO\nthe\tO\nroad\tO\nbetween\tO\nthe\tO\ntowns\tT-0\nof\tO\nRousse\tT-3\nand\tO\nVeliko\tB-LOC\nTarnovo\tI-LOC\n,\tO\npolice\tT-2\nsaid\tT-2\n.\tT-2\n\nA\tT-1\nRomanian\tB-MISC\nwoman\tT-2\nMaria\tT-3\nMarco\tT-3\n,\tO\n35\tO\n,\tO\nwas\tO\nkilled\tT-0\n.\tO\n\nA\tO\nRomanian\tO\nwoman\tT-0\nMaria\tB-PER\nMarco\tI-PER\n,\tO\n35\tO\n,\tO\nwas\tO\nkilled\tO\n.\tO\n\nOFFICIAL\tB-ORG\nJOURNAL\tI-ORG\nCONTENTS\tT-0\n-\tO\nOJ\tO\nL\tO\n211\tO\nOF\tO\nAUGUST\tT-1\n21\tO\n,\tO\n1996\tO\n.\tO\n\nOFFICIAL\tO\nJOURNAL\tO\nCONTENTS\tT-0\n-\tO\nOJ\tB-ORG\nL\tO\n211\tO\nOF\tO\nAUGUST\tO\n21\tO\n,\tO\n1996\tO\n.\tO\n\n(\tO\nNote\tO\n-\tO\ncontents\tO\nare\tO\ndisplayed\tO\nin\tO\nreverse\tO\norder\tO\nto\tO\nthat\tO\nin\tO\nthe\tO\nprinted\tT-0\nJournal\tB-ORG\n)\tO\n\nCorrigendum\tT-0\nto\tO\nCommission\tB-MISC\nRegulation\tI-MISC\n(\tO\nEC\tO\n)\tO\nNo\tO\n1464/96\tO\nof\tO\n25\tO\nJuly\tO\n1996\tO\nrelating\tO\nto\tO\na\tO\nstanding\tO\ninvitation\tO\nto\tO\ntender\tO\nto\tO\ndetermine\tO\nlevies\tO\nand\tO\n/\tO\nor\tO\nrefunds\tO\non\tO\nexports\tO\nof\tO\nwhite\tO\nsugar\tO\n(\tO\nOJ\tO\nNo\tO\nL\tO\n187\tO\nof\tO\n26.7.1996\tO\n)\tO\n\nCorrigendum\tO\nto\tO\nCommission\tO\nRegulation\tO\n(\tO\nEC\tB-ORG\n)\tO\nNo\tO\n1464/96\tO\nof\tO\n25\tO\nJuly\tO\n1996\tO\nrelating\tO\nto\tO\na\tO\nstanding\tO\ninvitation\tT-1\nto\tO\ntender\tO\nto\tO\ndetermine\tT-2\nlevies\tO\nand\tO\n/\tO\nor\tO\nrefunds\tO\non\tO\nexports\tO\nof\tO\nwhite\tO\nsugar\tO\n(\tO\nOJ\tT-0\nNo\tT-0\nL\tT-0\n187\tT-0\nof\tT-0\n26.7.1996\tT-0\n)\tO\n\nCorrigendum\tT-0\nto\tO\nCommission\tB-MISC\nRegulation\tI-MISC\n(\tO\nEC\tO\n)\tO\nNo\tT-2\n658/96\tT-2\nof\tT-2\n9\tT-2\nApril\tT-2\n1996\tT-2\non\tO\ncertain\tO\nconditions\tO\nfor\tO\ngranting\tT-1\ncompensatory\tT-1\npayments\tO\nunder\tO\nthe\tO\nsupport\tO\nsystem\tO\nfor\tO\nproducers\tO\nof\tO\ncertain\tO\narable\tO\ncrops\tO\n(\tO\nOJ\tO\nNo\tO\nL\tO\n91\tO\nof\tO\n12.4.1996\tO\n)\tO\n\nCorrigendum\tO\nto\tO\nCommission\tO\nRegulation\tO\n(\tO\nEC\tB-ORG\n)\tO\nNo\tO\n658/96\tO\nof\tO\n9\tO\nApril\tO\n1996\tO\non\tO\ncertain\tO\nconditions\tO\nfor\tO\ngranting\tT-0\ncompensatory\tO\npayments\tT-2\nunder\tO\nthe\tO\nsupport\tO\nsystem\tO\nfor\tO\nproducers\tO\nof\tO\ncertain\tO\narable\tO\ncrops\tT-1\n(\tO\nOJ\tO\nNo\tO\nL\tO\n91\tO\nof\tO\n12.4.1996\tO\n)\tO\n\nCorrigendum\tT-1\nto\tO\nCommission\tO\nRegulation\tO\n(\tO\nEC\tO\n)\tO\nNo\tO\n658/96\tO\nof\tO\n9\tO\nApril\tO\n1996\tO\non\tO\ncertain\tO\nconditions\tO\nfor\tO\ngranting\tT-0\ncompensatory\tT-0\npayments\tT-0\nunder\tO\nthe\tO\nsupport\tO\nsystem\tO\nfor\tO\nproducers\tO\nof\tO\ncertain\tO\narable\tO\ncrops\tO\n(\tO\nOJ\tB-ORG\nNo\tO\nL\tO\n91\tO\nof\tO\n12.4.1996\tO\n)\tO\n\nCommission\tB-MISC\nRegulation\tI-MISC\n(\tO\nEC\tT-3\n)\tO\nNo\tO\n1663/96\tO\nof\tO\n20\tO\nAugust\tO\n1996\tO\nestablishing\tT-4\nthe\tO\nstandard\tT-1\nimport\tO\nvalues\tO\nfor\tO\ndetermining\tT-0\nthe\tO\nentry\tO\nprice\tO\nof\tO\ncertain\tO\nfruit\tO\nand\tO\nvegetables\tO\nEND\tO\nOF\tO\nDOCUMENT\tO\n.\tT-2\n\nCommission\tO\nRegulation\tT-2\n(\tO\nEC\tB-ORG\n)\tO\nNo\tT-1\n1663/96\tT-1\nof\tT-1\n20\tT-1\nAugust\tT-1\n1996\tT-1\nestablishing\tO\nthe\tO\nstandard\tO\nimport\tO\nvalues\tO\nfor\tO\ndetermining\tO\nthe\tO\nentry\tO\nprice\tO\nof\tO\ncertain\tO\nfruit\tO\nand\tO\nvegetables\tO\nEND\tT-0\nOF\tT-0\nDOCUMENT\tT-0\n.\tO\n\nIn\tB-ORG\nHome\tI-ORG\nHealth\tI-ORG\nto\tO\nappeal\tO\npayment\tT-0\ndenial\tO\n.\tO\n\nMINNETONKA\tB-LOC\n,\tO\nMinn\tT-0\n.\tO\n\nIn\tB-ORG\nHome\tI-ORG\nHealth\tI-ORG\nInc\tI-ORG\nsaid\tT-0\non\tO\nThursday\tT-1\nit\tT-2\nwill\tT-3\nappeal\tT-3\nto\tO\nthe\tO\nU.S.\tO\nFederal\tO\nDistrict\tO\nCourt\tO\nin\tO\nMinneapolis\tO\na\tO\ndecision\tO\nby\tO\nthe\tO\nHealth\tO\nCare\tO\nFinancing\tO\nAdministration\tO\n(\tO\nHCFA\tO\n)\tO\nthat\tO\ndenied\tO\nreimbursement\tO\nof\tO\ncertain\tO\ncosts\tO\nunder\tO\nMedicaid\tO\n.\tO\n\nIn\tO\nHome\tT-1\nHealth\tT-1\nInc\tT-1\nsaid\tT-2\non\tO\nThursday\tO\nit\tO\nwill\tO\nappeal\tO\nto\tT-0\nthe\tT-0\nU.S.\tB-ORG\nFederal\tI-ORG\nDistrict\tI-ORG\nCourt\tI-ORG\nin\tO\nMinneapolis\tO\na\tO\ndecision\tO\nby\tO\nthe\tO\nHealth\tO\nCare\tO\nFinancing\tO\nAdministration\tO\n(\tO\nHCFA\tO\n)\tO\nthat\tO\ndenied\tO\nreimbursement\tO\nof\tO\ncertain\tO\ncosts\tO\nunder\tO\nMedicaid\tO\n.\tO\n\nIn\tO\nHome\tO\nHealth\tO\nInc\tO\nsaid\tT-1\non\tO\nThursday\tO\nit\tO\nwill\tO\nappeal\tO\nto\tO\nthe\tO\nU.S.\tT-4\nFederal\tT-4\nDistrict\tT-4\nCourt\tT-4\nin\tT-0\nMinneapolis\tB-LOC\na\tO\ndecision\tT-2\nby\tO\nthe\tO\nHealth\tT-5\nCare\tT-5\nFinancing\tT-5\nAdministration\tT-5\n(\tT-5\nHCFA\tT-5\n)\tT-5\nthat\tO\ndenied\tT-3\nreimbursement\tO\nof\tO\ncertain\tO\ncosts\tO\nunder\tO\nMedicaid\tT-6\n.\tO\n\nIn\tO\nHome\tT-0\nHealth\tT-0\nInc\tO\nsaid\tO\non\tO\nThursday\tO\nit\tO\nwill\tO\nappeal\tO\nto\tO\nthe\tO\nU.S.\tO\nFederal\tO\nDistrict\tO\nCourt\tO\nin\tO\nMinneapolis\tO\na\tO\ndecision\tT-3\nby\tT-1\nthe\tT-1\nHealth\tB-ORG\nCare\tI-ORG\nFinancing\tI-ORG\nAdministration\tI-ORG\n(\tO\nHCFA\tT-2\n)\tO\nthat\tO\ndenied\tO\nreimbursement\tO\nof\tO\ncertain\tO\ncosts\tO\nunder\tO\nMedicaid\tO\n.\tO\n\nIn\tO\nHome\tO\nHealth\tO\nInc\tO\nsaid\tO\non\tO\nThursday\tO\nit\tO\nwill\tO\nappeal\tO\nto\tO\nthe\tO\nU.S.\tO\nFederal\tO\nDistrict\tO\nCourt\tO\nin\tO\nMinneapolis\tO\na\tO\ndecision\tT-1\nby\tT-1\nthe\tO\nHealth\tT-0\nCare\tT-0\nFinancing\tT-0\nAdministration\tT-0\n(\tO\nHCFA\tB-ORG\n)\tO\nthat\tO\ndenied\tO\nreimbursement\tO\nof\tO\ncertain\tO\ncosts\tO\nunder\tO\nMedicaid\tO\n.\tO\n\nIn\tO\nHome\tO\nHealth\tO\nInc\tO\nsaid\tO\non\tO\nThursday\tO\nit\tO\nwill\tO\nappeal\tT-1\nto\tO\nthe\tO\nU.S.\tO\nFederal\tO\nDistrict\tO\nCourt\tO\nin\tO\nMinneapolis\tO\na\tO\ndecision\tO\nby\tO\nthe\tO\nHealth\tO\nCare\tO\nFinancing\tO\nAdministration\tO\n(\tO\nHCFA\tO\n)\tO\nthat\tO\ndenied\tT-2\nreimbursement\tT-0\nof\tO\ncertain\tO\ncosts\tO\nunder\tO\nMedicaid\tB-MISC\n.\tO\n\nThe\tO\nHCFA\tB-ORG\nAdministrator\tT-0\nreversed\tT-1\na\tO\npreviously\tO\nfavorable\tO\ndecision\tT-2\nregarding\tO\nthe\tO\nreimbursement\tO\nof\tO\ncosts\tO\nrelated\tO\nto\tO\nthe\tO\ncompany\tT-3\n's\tO\ncommunity\tO\nliaison\tO\npersonnel\tO\n,\tO\nit\tO\nadded\tO\n.\tO\n\nThe\tO\ncompany\tO\nsaid\tO\nit\tO\ncontinues\tO\nto\tO\nbelieve\tO\nthe\tO\nmajority\tO\nof\tO\nthe\tO\ncommunity\tT-0\nliaison\tT-0\ncosts\tT-0\nare\tO\ncoverable\tT-1\nunder\tO\nthe\tO\nterms\tO\nof\tO\nthe\tO\nMedicare\tB-MISC\nprogram\tO\n.\tO\n\n\"\tO\nWe\tO\nare\tO\ndisappointed\tO\nwith\tO\nthe\tO\nadministrator\tO\n's\tO\ndecision\tO\nbut\tO\nwe\tO\ncontinue\tO\nto\tO\nbe\tO\noptimistic\tO\nregarding\tO\nan\tO\nultimate\tO\nfavorable\tO\nresolution\tO\n,\tO\n\"\tO\nMark\tB-PER\nGildea\tI-PER\n,\tO\nchief\tT-0\nexecutive\tT-1\nofficer\tT-2\n,\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\n.\tO\n\nIn\tB-ORG\nHome\tI-ORG\nHealth\tI-ORG\nsaid\tT-2\nit\tO\npreviously\tO\nrecorded\tT-1\na\tO\nreserve\tO\nequal\tO\nto\tO\n16\tO\npercent\tO\nof\tO\nall\tO\nrevenue\tT-0\nrelated\tO\nto\tO\nthe\tO\ncommunity\tO\nliaison\tO\ncosts\tO\n.\tO\n\nSeparately\tO\n,\tO\nIn\tB-ORG\nHome\tI-ORG\nHealth\tI-ORG\nsaid\tT-0\nthe\tO\nU.S.\tO\nDistrict\tT-2\nCourt\tT-2\nin\tO\nMinneapolis\tT-3\nruled\tO\nin\tO\nits\tT-1\nfavor\tO\nregarding\tO\nthe\tO\nreimbursement\tO\nof\tO\ncertain\tO\ninterest\tO\nexpenses\tO\n.\tO\n\nSeparately\tO\n,\tO\nIn\tO\nHome\tO\nHealth\tO\nsaid\tT-0\nthe\tO\nU.S.\tB-ORG\nDistrict\tI-ORG\nCourt\tI-ORG\nin\tO\nMinneapolis\tT-2\nruled\tT-3\nin\tO\nits\tO\nfavor\tO\nregarding\tO\nthe\tO\nreimbursement\tT-1\nof\tO\ncertain\tO\ninterest\tO\nexpenses\tO\n.\tO\n\nSeparately\tO\n,\tO\nIn\tO\nHome\tO\nHealth\tO\nsaid\tO\nthe\tO\nU.S.\tT-0\nDistrict\tT-0\nCourt\tT-0\nin\tO\nMinneapolis\tB-LOC\nruled\tO\nin\tO\nits\tO\nfavor\tO\nregarding\tO\nthe\tO\nreimbursement\tO\nof\tO\ncertain\tO\ninterest\tO\nexpenses\tO\n.\tO\n\nThis\tO\ndecision\tO\nwill\tO\nresult\tO\nin\tO\nthe\tO\nreimbursement\tT-1\nby\tT-0\nMedicare\tB-MISC\nof\tO\n$\tO\n81,000\tO\nin\tO\ndisputed\tT-2\ncosts\tT-2\n.\tO\n\n\"\tO\nThis\tO\nis\tO\nour\tO\nfirst\tO\ndecision\tO\nin\tO\nfederal\tO\ndistrct\tO\ncourt\tT-0\nregarding\tO\na\tO\ndispute\tT-2\nwith\tO\nMedicare\tB-MISC\n,\tO\n\"\tO\nGildea\tT-3\nsaid\tT-1\n.\tO\n\"\tO\n\n\"\tO\nThis\tO\nis\tO\nour\tO\nfirst\tT-0\ndecision\tT-0\nin\tO\nfederal\tO\ndistrct\tO\ncourt\tO\nregarding\tO\na\tO\ndispute\tO\nwith\tO\nMedicare\tO\n,\tO\n\"\tO\nGildea\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\nWe\tO\nare\tO\nextremely\tO\npleased\tO\nwith\tO\nthis\tO\ndecision\tT-0\nand\tO\nwe\tO\nrecognize\tO\nit\tO\nas\tO\na\tO\nsignificant\tO\nstep\tO\ntoward\tO\nresolution\tO\nof\tO\nour\tO\noutstanding\tT-1\nMedicare\tB-MISC\ndisputes\tO\n.\tO\n\"\tO\n\n--\tO\nChicago\tB-ORG\nNewsdesk\tI-ORG\n312-408-8787\tT-0\n\nOppenheimer\tB-ORG\nCapital\tI-ORG\nLP\tI-ORG\nsaid\tT-0\non\tO\nThursday\tO\nit\tO\nwill\tO\nreview\tO\nits\tO\ncash\tO\ndistribution\tO\nrate\tO\nfor\tO\nthe\tO\nOctober\tO\nquarterly\tO\ndistribution\tO\n,\tO\nassuming\tO\ncontinued\tO\nfavorable\tO\nresults\tO\n.\tO\n\nBest\tB-ORG\nsees\tT-0\nQ2\tO\nloss\tT-1\nsimilar\tO\nto\tO\nQ1\tO\nloss\tO\n.\tO\n\nRICHMOND\tB-LOC\n,\tO\nVa\tT-0\n.\tO\n\nBest\tB-ORG\nProducts\tI-ORG\nCo\tI-ORG\nChairman\tT-3\nand\tO\nChief\tT-0\nExecutive\tO\nDaniel\tO\nLevy\tO\nsaid\tT-1\nThursday\tO\nhe\tO\nexpected\tO\nthe\tO\ncompany\tT-2\n's\tT-2\nsecond-quarter\tT-2\nresults\tO\nto\tO\nbe\tO\nsimilar\tO\nto\tO\nthe\tO\n$\tO\n34.6\tO\nmillion\tO\nloss\tO\nposted\tO\nin\tO\nthe\tO\nfirst\tO\nquarter\tO\n.\tO\n\nBest\tO\nProducts\tO\nCo\tT-1\nChairman\tT-1\nand\tT-1\nChief\tT-1\nExecutive\tT-1\nDaniel\tB-PER\nLevy\tI-PER\nsaid\tT-3\nThursday\tO\nhe\tO\nexpected\tO\nthe\tO\ncompany\tT-2\n's\tO\nsecond-quarter\tO\nresults\tO\nto\tO\nbe\tO\nsimilar\tO\nto\tO\nthe\tO\n$\tO\n34.6\tO\nmillion\tO\nloss\tT-4\nposted\tO\nin\tO\nthe\tO\nfirst\tO\nquarter\tO\n.\tO\n\nHe\tO\nalso\tO\ntold\tT-1\nReuters\tB-ORG\nbefore\tO\nthe\tT-2\nretailer\tT-2\n's\tO\nannual\tT-0\nmeeting\tT-0\nthat\tO\nthe\tO\nsecond\tO\nquarter\tO\ncould\tO\nbe\tO\nbetter\tO\nthan\tO\nthe\tO\nfirst\tO\nquarter\tO\nended\tO\nMay\tO\n4\tO\n.\tO\n\"\tO\n\nLevy\tB-PER\nsaid\tO\nseeking\tO\nbankruptcy\tO\nprotection\tT-0\nwas\tO\nnot\tO\nunder\tO\nconsideration\tT-1\n.\tO\n\nBest\tB-ORG\nemerged\tO\nfrom\tO\nChapter\tO\n11\tO\nbankruptcy\tT-1\nprotection\tT-0\nin\tO\nJune\tO\n1994\tO\nafter\tO\n3-1/2\tO\nyears\tO\n.\tO\n\nBest\tO\nemerged\tT-1\nfrom\tO\nChapter\tB-MISC\n11\tI-MISC\nbankruptcy\tO\nprotection\tT-0\nin\tO\nJune\tO\n1994\tO\nafter\tO\n3-1/2\tO\nyears\tO\n.\tO\n\n\"\tO\nBankruptcy\tO\nis\tO\nalways\tO\npossible\tT-1\n,\tO\nparticularly\tO\nwhen\tO\nyou\tT-0\nlose\tO\nwhat\tO\nwe\tO\nare\tO\ngoing\tO\nto\tO\nlose\tO\nin\tO\nthe\tO\nfirst\tO\nhalf\tO\nof\tO\nthis\tO\nyear\tO\n,\tO\n\"\tO\nLevy\tB-PER\nsaid\tT-2\n.\tO\n\"\tO\n\nThe\tT-0\nRichmond-based\tB-MISC\nretailer\tT-3\nlost\tT-1\n$\tT-2\n95.7\tT-2\nmillion\tO\nin\tO\nthe\tO\nfiscal\tO\nyear\tO\nended\tO\nFebruary\tO\n3\tO\n.\tO\n\nLevy\tB-PER\nsaid\tT-0\nthat\tO\nBest\tT-1\nplanned\tO\nto\tO\nopen\tO\ntwo\tO\nnew\tO\nstores\tO\nthis\tO\nfall\tO\n.\tO\n\nLevy\tO\nsaid\tO\nthat\tO\nBest\tB-ORG\nplanned\tT-0\nto\tT-0\nopen\tT-0\ntwo\tT-0\nnew\tT-0\nstores\tT-0\nthis\tO\nfall\tO\n.\tO\n\nAt\tO\nthe\tO\ntime\tO\n,\tO\nBest\tB-ORG\nsaid\tT-1\nit\tO\ndid\tO\nnot\tO\nplan\tT-0\nto\tO\nopen\tO\nany\tO\nnew\tO\nstores\tO\nthis\tO\nfall\tO\n.\tO\n\nFor\tO\nlast\tO\nyear\tO\n's\tO\nsecond\tT-0\nquarter\tT-0\n,\tO\nwhich\tO\nended\tO\nJuly\tO\n29\tO\n,\tO\n1995\tO\n,\tO\nBest\tB-ORG\nposted\tT-2\na\tO\nloss\tT-1\nof\tO\n$\tO\n7.1\tO\nmillion\tO\n,\tO\nor\tO\n$\tO\n0.23\tO\nper\tO\nshare\tO\n,\tO\non\tO\nsales\tO\nof\tO\n$\tO\n311.9\tO\nmillion\tO\n.\tO\n\nWomen\tT-2\nwho\tO\nget\tO\nmeasles\tO\nwhile\tO\npregnant\tT-0\nmay\tO\nhave\tO\nbabies\tT-1\nat\tO\nhigher\tO\nrisk\tO\nof\tO\nCrohn\tB-PER\n's\tO\ndisease\tT-3\n,\tO\na\tO\ndebilitating\tO\nbowel\tO\ndisorder\tO\n,\tO\nresearchers\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nThree\tT-0\nout\tT-0\nof\tT-0\nfour\tT-0\nSwedish\tB-MISC\nbabies\tT-1\nborn\tO\nto\tO\nmothers\tO\nwho\tO\ncaught\tT-2\nmeasles\tO\ndeveloped\tO\nserious\tO\ncases\tO\nof\tO\nCrohn\tO\n's\tO\ndisease\tO\n,\tO\nthe\tO\nresearchers\tO\nsaid\tO\n.\tO\n\nThree\tO\nout\tO\nof\tO\nfour\tO\nSwedish\tT-0\nbabies\tT-0\nborn\tT-3\nto\tO\nmothers\tT-1\nwho\tO\ncaught\tT-4\nmeasles\tT-2\ndeveloped\tO\nserious\tO\ncases\tT-5\nof\tO\nCrohn\tB-PER\n's\tO\ndisease\tO\n,\tO\nthe\tO\nresearchers\tO\nsaid\tT-6\n.\tO\n\nDr\tT-4\nAndrew\tB-PER\nWakefield\tI-PER\nof\tO\nthe\tO\nRoyal\tO\nFree\tT-0\nHospital\tT-0\nSchool\tT-0\nof\tO\nMedicine\tO\nand\tT-5\ncolleagues\tT-5\nscreened\tT-3\n25,000\tO\nbabies\tT-1\ndelivered\tO\nat\tO\nUniversity\tT-2\nHospital\tT-2\n,\tO\nUppsala\tO\n,\tO\nbetween\tO\n1940\tO\nand\tO\n1949\tO\n.\tO\n\nDr\tT-1\nAndrew\tT-1\nWakefield\tT-1\nof\tO\nthe\tO\nRoyal\tB-LOC\nFree\tI-LOC\nHospital\tI-LOC\nSchool\tI-LOC\nof\tI-LOC\nMedicine\tI-LOC\nand\tO\ncolleagues\tO\nscreened\tT-0\n25,000\tO\nbabies\tO\ndelivered\tO\nat\tO\nUniversity\tO\nHospital\tO\n,\tO\nUppsala\tO\n,\tO\nbetween\tO\n1940\tO\nand\tO\n1949\tO\n.\tO\n\nDr\tO\nAndrew\tO\nWakefield\tO\nof\tO\nthe\tO\nRoyal\tO\nFree\tO\nHospital\tO\nSchool\tO\nof\tO\nMedicine\tO\nand\tO\ncolleagues\tO\nscreened\tT-0\n25,000\tO\nbabies\tO\ndelivered\tO\nat\tT-1\nUniversity\tB-LOC\nHospital\tI-LOC\n,\tO\nUppsala\tO\n,\tO\nbetween\tO\n1940\tO\nand\tO\n1949\tO\n.\tO\n\nDr\tT-0\nAndrew\tT-0\nWakefield\tT-0\nof\tO\nthe\tO\nRoyal\tT-1\nFree\tT-1\nHospital\tT-1\nSchool\tT-1\nof\tT-1\nMedicine\tT-1\nand\tO\ncolleagues\tO\nscreened\tO\n25,000\tO\nbabies\tT-3\ndelivered\tO\nat\tO\nUniversity\tT-2\nHospital\tT-2\n,\tO\nUppsala\tB-LOC\n,\tO\nbetween\tO\n1940\tO\nand\tO\n1949\tO\n.\tO\n\n\"\tO\nThree\tO\nof\tO\nthe\tO\nfour\tO\nchildren\tT-0\nhad\tT-1\nCrohn\tB-PER\n's\tO\ndisease\tT-2\n,\tO\n\"\tO\nWakefield\tO\n's\tO\ngroup\tO\nwrote\tO\nin\tO\nthe\tO\nLancet\tO\nmedical\tO\njournal\tO\n.\tO\n\n\"\tO\nThree\tO\nof\tO\nthe\tO\nfour\tO\nchildren\tO\nhad\tO\nCrohn\tO\n's\tO\ndisease\tT-1\n,\tO\n\"\tO\nWakefield\tB-PER\n's\tO\ngroup\tO\nwrote\tO\nin\tO\nthe\tO\nLancet\tT-0\nmedical\tT-0\njournal\tT-0\n.\tO\n\n\"\tO\nThree\tO\nof\tO\nthe\tO\nfour\tO\nchildren\tO\nhad\tO\nCrohn\tO\n's\tO\ndisease\tO\n,\tO\n\"\tO\nWakefield\tT-1\n's\tT-1\ngroup\tO\nwrote\tT-0\nin\tT-0\nthe\tT-0\nLancet\tB-ORG\nmedical\tT-2\njournal\tT-2\n.\tO\n\nCrohn\tB-PER\n's\tO\nis\tO\nan\tO\ninflammation\tT-0\nof\tO\nthe\tO\nbowel\tO\nthat\tO\ncan\tO\nsometimes\tO\nrequire\tO\nsurgery\tO\n.\tO\n\nMost\tO\nnotably\tO\n,\tO\nwomen\tO\nwho\tO\nget\tT-0\nrubella\tT-2\n(\tO\nGerman\tB-MISC\nmeasles\tT-1\n)\tO\nhave\tO\na\tO\nhigh\tO\nrisk\tO\nof\tO\na\tO\nstillborn\tO\nbaby\tO\n.\tO\n\nAll\tO\nthe\tO\nkey\tO\nnumbers\tT-0\n-\tO\nCBI\tB-ORG\nAugust\tO\nindustrial\tO\ntrends\tT-1\n.\tO\n\nFollowing\tO\nare\tO\nkey\tO\ndata\tO\nfrom\tO\nthe\tO\nAugust\tO\nmonthly\tO\nsurvey\tO\nof\tO\ntrends\tO\nin\tO\nUK\tB-LOC\nmanufacturing\tT-1\nby\tO\nthe\tO\nConfederation\tT-0\nof\tT-0\nBritish\tT-2\nIndustry\tT-2\n(\tO\nCBI\tO\n)\tO\n.\tO\n\nFollowing\tO\nare\tO\nkey\tO\ndata\tO\nfrom\tO\nthe\tO\nAugust\tO\nmonthly\tT-1\nsurvey\tT-1\nof\tT-1\ntrends\tT-1\nin\tT-1\nUK\tT-2\nmanufacturing\tO\nby\tT-0\nthe\tT-0\nConfederation\tB-ORG\nof\tI-ORG\nBritish\tI-ORG\nIndustry\tI-ORG\n(\tO\nCBI\tO\n)\tO\n.\tO\n\nFollowing\tO\nare\tO\nkey\tO\ndata\tO\nfrom\tO\nthe\tO\nAugust\tT-3\nmonthly\tO\nsurvey\tT-1\nof\tO\ntrends\tT-0\nin\tO\nUK\tT-4\nmanufacturing\tT-4\nby\tO\nthe\tO\nConfederation\tT-2\nof\tT-2\nBritish\tT-2\nIndustry\tT-2\n(\tO\nCBI\tB-ORG\n)\tO\n.\tO\n\nCBI\tB-ORG\nMONTHLY\tO\nTRENDS\tT-3\nENQUIRY\tO\n(\tO\na\tO\n)\tO\nAUG\tT-0\nJULY\tT-1\nJUNE\tT-1\nMAY\tT-2\n\nThe\tO\nsurvey\tT-0\nwas\tO\nconducted\tO\nbetween\tO\nJuly\tO\n23\tO\nand\tO\nAugust\tO\n14\tO\nand\tO\ninvolved\tO\n1,305\tT-3\ncompanies\tT-3\n,\tO\nrepresenting\tO\n50\tO\nindustries\tO\n,\tO\naccounting\tO\nfor\tO\naround\tT-1\nhalf\tO\nof\tO\nthe\tO\nUK\tB-LOC\n's\tO\nmanufactured\tT-2\nexports\tO\nand\tO\nsome\tO\ntwo\tT-4\nmillion\tT-4\nemployees\tT-4\n.\tO\n\n--\tO\nRosemary\tB-PER\nBennett\tI-PER\n,\tO\nLondon\tO\nNewsroom\tT-0\n+44\tO\n171\tO\n542\tO\n7715\tT-0\n\n--\tO\nRosemary\tT-0\nBennett\tT-0\n,\tO\nLondon\tB-ORG\nNewsroom\tI-ORG\n+44\tO\n171\tO\n542\tO\n7715\tO\n\nIron\tB-MISC\nGippsland\tI-MISC\n-\tO\n(\tO\nbuilt\tT-0\n1989\tO\n)\tO\n87,241\tO\ndwt\tT-2\nsold\tO\nto\tO\nGreek\tO\nbuyers\tT-1\nfor\tO\n$\tO\n30\tO\nmillion\tO\n.\tO\n\nIron\tO\nGippsland\tO\n-\tO\n(\tO\nbuilt\tO\n1989\tO\n)\tO\n87,241\tO\ndwt\tO\nsold\tT-0\nto\tT-0\nGreek\tB-MISC\nbuyers\tT-1\nfor\tO\n$\tO\n30\tO\nmillion\tO\n.\tO\n\nSairyu\tB-MISC\nMaru\tI-MISC\nNo\tI-MISC\n:\tI-MISC\n2\tI-MISC\n-\tO\n(\tO\nbuilt\tT-0\n1982\tO\n)\tO\n60,960\tO\ndwt\tO\nsold\tO\nto\tO\nGreek\tT-1\nbuyers\tT-1\nfor\tO\n$\tO\n15.5\tO\nmillion\tO\n.\tO\n\nSairyu\tT-1\nMaru\tT-1\nNo\tO\n:\tO\n2\tO\n-\tO\n(\tO\nbuilt\tO\n1982\tO\n)\tO\n60,960\tO\ndwt\tO\nsold\tO\nto\tO\nGreek\tB-MISC\nbuyers\tT-0\nfor\tO\n$\tO\n15.5\tO\nmillion\tO\n.\tO\n\nStainless\tB-MISC\nFighter\tI-MISC\n-\tO\n(\tO\nbuilt\tT-1\n1970\tT-0\n)\tO\n21,718\tO\ndwt\tT-2\nsold\tO\nat\tO\nauction\tO\nfor\tO\n$\tO\n6\tO\nmillion\tO\n.\tO\n\nGarlic\tT-0\npills\tO\nmay\tO\nnot\tO\nlower\tO\nblood\tO\ncholesterol\tO\nand\tO\nstudies\tO\nthat\tO\nshow\tO\nthey\tO\ndo\tO\nmay\tO\nbe\tO\nflawed\tT-1\n,\tO\nBritish\tB-MISC\nresearchers\tT-2\nhave\tO\nreported\tO\n.\tO\n\nA\tO\nstudy\tO\nby\tO\na\tO\nteam\tT-3\nof\tO\ndoctors\tO\nat\tO\nOxford\tB-ORG\nUniversity\tI-ORG\nhas\tO\nfound\tT-0\npeople\tO\nwith\tO\nhigh\tO\nblood\tT-1\ncholesterol\tT-1\ndo\tO\nnot\tO\nbenefit\tO\nsignificantly\tO\nfrom\tO\ntaking\tO\ngarlic\tT-2\ntablets\tT-2\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nsignificant\tO\ndifferences\tO\nbetween\tT-2\nthe\tO\ngroups\tO\nreceiving\tT-3\ngarlic\tO\nand\tO\nplacebo\tT-0\n,\tO\n\"\tO\nthey\tT-1\nwrote\tT-1\nin\tO\nthe\tO\nJournal\tB-ORG\nof\tI-ORG\nthe\tI-ORG\nRoyal\tI-ORG\nCollege\tI-ORG\nof\tI-ORG\nPhysicians\tI-ORG\n.\tO\n\nBut\tO\nthe\tO\nOxford\tB-LOC\nteam\tT-0\ndisputed\tO\nthese\tO\nfindings\tO\nand\tO\nsaid\tO\neither\tO\nprevious\tO\ntrials\tO\nmay\tO\nhave\tO\nbeen\tO\ninterpreted\tO\nincorrectly\tO\n,\tO\nthose\tO\ntaking\tO\npart\tO\nwere\tO\nnot\tO\ngiven\tO\nspecial\tO\ndiets\tO\nbeforehand\tO\nor\tO\nthe\tO\nduration\tO\nof\tO\nthe\tO\nstudies\tO\nmay\tO\nhave\tO\nbeen\tO\ntoo\tO\nshort\tO\n.\tO\n\nThe\tO\nsix-month\tO\ntrial\tT-0\nwas\tO\nfunded\tT-1\nby\tO\nthe\tT-3\nBritish\tB-ORG\nHeart\tI-ORG\nFoundation\tI-ORG\nand\tO\nLichtwer\tT-2\nPharma\tT-2\nGmbH\tT-2\n,\tO\nwhich\tO\nmakes\tO\nKwai\tO\nbrand\tO\ngarlic\tO\ntablets\tO\n.\tO\n\nThe\tO\nsix-month\tO\ntrial\tO\nwas\tO\nfunded\tO\nby\tO\nthe\tO\nBritish\tT-2\nHeart\tT-2\nFoundation\tT-0\nand\tO\nLichtwer\tB-ORG\nPharma\tI-ORG\nGmbH\tI-ORG\n,\tO\nwhich\tO\nmakes\tO\nKwai\tT-3\nbrand\tO\ngarlic\tT-1\ntablets\tT-1\n.\tO\n\nThe\tO\nsix-month\tT-0\ntrial\tT-0\nwas\tO\nfunded\tO\nby\tO\nthe\tO\nBritish\tO\nHeart\tO\nFoundation\tO\nand\tO\nLichtwer\tO\nPharma\tO\nGmbH\tO\n,\tO\nwhich\tO\nmakes\tO\nKwai\tB-MISC\nbrand\tO\ngarlic\tO\ntablets\tO\n.\tO\n\nBritain\tB-LOC\ngives\tT-1\naid\tO\nto\tO\nvolcano-hit\tO\nCaribbean\tT-0\nisland\tT-0\n.\tO\n\nBritain\tT-1\ngives\tT-0\naid\tT-0\nto\tO\nvolcano-hit\tT-2\nCaribbean\tB-LOC\nisland\tT-3\n.\tO\n\nBritain\tB-LOC\nsaid\tT-0\non\tO\nThursday\tO\nit\tO\nwould\tO\ngive\tT-1\n25\tO\nmillion\tO\npounds\tO\n(\tO\n$\tO\n39\tO\nmillion\tO\n)\tO\nof\tO\ndevelopment\tT-2\naid\tT-3\nto\tO\nthe\tO\nCaribbean\tO\nisland\tO\nof\tO\nMontserrat\tO\n,\tO\nwhere\tO\nmuch\tO\nof\tO\nthe\tO\npopulation\tO\nliving\tO\nin\tO\nthe\tO\nsouth\tO\nhas\tO\nfled\tO\nto\tO\navoid\tO\na\tO\nvolcano\tO\n.\tO\n\nBritain\tO\nsaid\tO\non\tO\nThursday\tO\nit\tO\nwould\tO\ngive\tT-3\n25\tT-3\nmillion\tT-3\npounds\tT-3\n(\tO\n$\tO\n39\tO\nmillion\tO\n)\tO\nof\tO\ndevelopment\tO\naid\tT-0\nto\tT-0\nthe\tT-0\nCaribbean\tB-LOC\nisland\tT-1\nof\tT-1\nMontserrat\tT-1\n,\tO\nwhere\tO\nmuch\tO\nof\tO\nthe\tO\npopulation\tO\nliving\tO\nin\tO\nthe\tO\nsouth\tO\nhas\tO\nfled\tO\nto\tO\navoid\tO\na\tO\nvolcano\tO\n.\tO\n\nBritain\tT-0\nsaid\tO\non\tO\nThursday\tO\nit\tO\nwould\tO\ngive\tO\n25\tO\nmillion\tO\npounds\tO\n(\tO\n$\tO\n39\tO\nmillion\tO\n)\tO\nof\tO\ndevelopment\tT-2\naid\tO\nto\tO\nthe\tO\nCaribbean\tT-1\nisland\tT-1\nof\tO\nMontserrat\tB-LOC\n,\tO\nwhere\tO\nmuch\tO\nof\tO\nthe\tO\npopulation\tO\nliving\tO\nin\tO\nthe\tO\nsouth\tO\nhas\tO\nfled\tO\nto\tO\navoid\tO\na\tO\nvolcano\tO\n.\tO\n\nThe\tO\nvolcano\tO\nin\tO\nthe\tO\nSoufriere\tT-0\nhills\tT-0\nhas\tO\nerupted\tT-2\nthree\tO\ntimes\tO\nin\tO\nthe\tO\npast\tO\n13\tO\nmonths\tO\nand\tO\nlast\tO\nApril\tO\nsome\tO\n4,500\tO\npeople\tT-1\nliving\tT-1\nin\tT-1\nthe\tO\ncapital\tO\n,\tO\nPlymouth\tB-ORG\n,\tO\nand\tO\nsouthern\tO\nareas\tO\nwere\tO\nevacuated\tT-3\nto\tO\nthe\tO\nnorth\tO\n,\tO\nwhere\tO\nmany\tO\nare\tO\nliving\tO\nin\tO\npublic\tO\nshelters\tO\nand\tO\nschools\tO\n.\tO\n\n\"\tO\nThis\tO\nassistance\tO\nwill\tO\nprovide\tO\na\tO\nfast\tO\ntrack\tO\ndevelopment\tO\nprogramme\tO\nfor\tO\nthe\tO\ndesignated\tO\n(\tO\nnorthern\tO\n)\tO\nsafe\tO\narea\tT-0\n,\tO\n\"\tO\nBritain\tB-LOC\n's\tO\nOverseas\tO\nDevelopment\tO\nAdministration\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\n.\tO\n\n\"\tO\nThis\tO\nassistance\tO\nwill\tO\nprovide\tT-0\na\tO\nfast\tO\ntrack\tO\ndevelopment\tO\nprogramme\tO\nfor\tO\nthe\tO\ndesignated\tT-1\n(\tO\nnorthern\tO\n)\tO\nsafe\tO\narea\tO\n,\tO\n\"\tO\nBritain\tO\n's\tO\nOverseas\tB-ORG\nDevelopment\tI-ORG\nAdministration\tI-ORG\nsaid\tT-2\nin\tO\na\tO\nstatement\tO\n.\tO\n\nBritain\tB-LOC\ngave\tT-1\n8.5\tO\nmillion\tO\npounds\tO\n(\tO\n$\tO\n13\tO\nmillion\tO\n)\tO\nto\tO\nMontserrat\tO\n,\tO\nwhich\tO\nis\tO\none\tO\nof\tO\nits\tO\ndependent\tO\nterritories\tO\n,\tO\nwhen\tO\nthe\tO\nvolcano\tO\nfirst\tO\nbecame\tO\nactive\tT-0\n.\tO\n\nBritain\tT-4\ngave\tT-1\n8.5\tT-5\nmillion\tT-5\npounds\tT-5\n(\tO\n$\tO\n13\tO\nmillion\tO\n)\tO\nto\tO\nMontserrat\tB-LOC\n,\tO\nwhich\tT-0\nis\tT-0\none\tO\nof\tO\nits\tO\ndependent\tT-2\nterritories\tO\n,\tO\nwhen\tO\nthe\tO\nvolcano\tO\nfirst\tO\nbecame\tO\nactive\tT-3\n.\tO\n\nOverseas\tO\nDevelopment\tO\nMinister\tO\nLynda\tB-PER\nChalker\tI-PER\nsaid\tO\na\tO\nrecent\tT-0\ncensus\tO\nhad\tO\nshown\tO\nmost\tO\nMontserratians\tO\nwanted\tO\nto\tO\nremain\tO\non\tO\nthe\tO\nisland\tO\n.\tO\n\"\tO\n\nOverseas\tT-0\nDevelopment\tT-0\nMinister\tT-0\nLynda\tO\nChalker\tO\nsaid\tO\na\tO\nrecent\tO\ncensus\tO\nhad\tO\nshown\tO\nmost\tT-1\nMontserratians\tB-MISC\nwanted\tT-2\nto\tT-2\nremain\tT-2\non\tT-2\nthe\tT-2\nisland\tT-2\n.\tO\n\"\tO\n\nTennis\tT-1\n-\tO\nPhilippoussis\tB-PER\nlooms\tT-0\nfor\tO\nSampras\tT-2\nin\tO\nU.S.\tO\nOpen\tO\n.\tO\n\nTennis\tO\n-\tO\nPhilippoussis\tO\nlooms\tO\nfor\tT-1\nSampras\tB-PER\nin\tO\nU.S.\tT-0\nOpen\tT-0\n.\tO\n\nTennis\tT-0\n-\tO\nPhilippoussis\tO\nlooms\tO\nfor\tO\nSampras\tT-1\nin\tO\nU.S.\tB-MISC\nOpen\tI-MISC\n.\tO\n\nWorld\tO\nnumber\tO\none\tO\nPete\tB-PER\nSampras\tI-PER\n,\tO\nseeking\tT-1\nhis\tO\nfirst\tO\nGrand\tT-0\nSlam\tT-0\ntitle\tO\nof\tO\nthe\tO\nyear\tO\n,\tO\nand\tO\nwomen\tO\n's\tO\ntop\tO\nseed\tO\nSteffi\tO\nGraf\tO\n,\tO\naiming\tO\nfor\tO\nher\tO\nthird\tO\n,\tO\nshould\tO\nbe\tO\nable\tT-2\nto\tO\nease\tO\ninto\tO\nthe\tO\nyear\tO\n's\tO\nfinal\tO\nmajor\tO\n,\tO\nwhich\tO\nbegins\tO\non\tO\nMonday\tO\n.\tO\n\nWorld\tO\nnumber\tO\none\tO\nPete\tO\nSampras\tO\n,\tO\nseeking\tT-2\nhis\tO\nfirst\tO\nGrand\tB-MISC\nSlam\tI-MISC\ntitle\tT-0\nof\tT-0\nthe\tT-0\nyear\tT-0\n,\tO\nand\tO\nwomen\tO\n's\tO\ntop\tO\nseed\tO\nSteffi\tO\nGraf\tO\n,\tO\naiming\tO\nfor\tO\nher\tO\nthird\tO\n,\tO\nshould\tO\nbe\tO\nable\tO\nto\tO\nease\tO\ninto\tO\nthe\tO\nyear\tO\n's\tO\nfinal\tT-1\nmajor\tT-1\n,\tO\nwhich\tO\nbegins\tO\non\tO\nMonday\tO\n.\tO\n\nWorld\tO\nnumber\tO\none\tO\nPete\tT-1\nSampras\tT-1\n,\tO\nseeking\tT-2\nhis\tT-2\nfirst\tO\nGrand\tO\nSlam\tO\ntitle\tO\nof\tO\nthe\tO\nyear\tO\n,\tO\nand\tO\nwomen\tT-0\n's\tO\ntop\tO\nseed\tO\nSteffi\tB-PER\nGraf\tI-PER\n,\tO\naiming\tO\nfor\tO\nher\tO\nthird\tO\n,\tO\nshould\tO\nbe\tO\nable\tO\nto\tO\nease\tO\ninto\tO\nthe\tO\nyear\tO\n's\tO\nfinal\tO\nmajor\tO\n,\tO\nwhich\tO\nbegins\tO\non\tO\nMonday\tO\n.\tO\n\nSampras\tB-PER\nopens\tT-0\nthe\tT-0\ndefence\tT-0\nof\tT-0\nhis\tT-0\nU.S.\tT-0\nOpen\tT-0\ncrown\tT-0\nagainst\tO\nDavid\tO\nRikl\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tO\n,\tO\nwhile\tO\ntop-ranked\tO\nGraf\tO\nbegins\tO\nher\tT-1\ntitle\tT-1\ndefence\tO\nagainst\tO\nYayuk\tO\nBasuki\tO\nof\tO\nIndonesia\tO\n.\tO\n\nSampras\tT-1\nopens\tO\nthe\tO\ndefence\tO\nof\tO\nhis\tO\nU.S.\tB-MISC\nOpen\tI-MISC\ncrown\tT-2\nagainst\tO\nDavid\tO\nRikl\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tT-0\n,\tO\nwhile\tO\ntop-ranked\tO\nGraf\tO\nbegins\tO\nher\tO\ntitle\tO\ndefence\tO\nagainst\tO\nYayuk\tO\nBasuki\tO\nof\tO\nIndonesia\tO\n.\tO\n\nSampras\tO\nopens\tO\nthe\tO\ndefence\tO\nof\tO\nhis\tO\nU.S.\tO\nOpen\tO\ncrown\tO\nagainst\tT-0\nDavid\tB-PER\nRikl\tI-PER\nof\tT-1\nthe\tT-1\nCzech\tT-1\nRepublic\tT-1\n,\tO\nwhile\tO\ntop-ranked\tO\nGraf\tO\nbegins\tO\nher\tT-2\ntitle\tT-2\ndefence\tO\nagainst\tO\nYayuk\tO\nBasuki\tO\nof\tO\nIndonesia\tO\n.\tO\n\nSampras\tO\nopens\tO\nthe\tO\ndefence\tO\nof\tO\nhis\tO\nU.S.\tO\nOpen\tO\ncrown\tO\nagainst\tO\nDavid\tT-1\nRikl\tT-1\nof\tO\nthe\tT-0\nCzech\tB-LOC\nRepublic\tI-LOC\n,\tO\nwhile\tT-2\ntop-ranked\tO\nGraf\tO\nbegins\tO\nher\tO\ntitle\tO\ndefence\tO\nagainst\tO\nYayuk\tO\nBasuki\tO\nof\tO\nIndonesia\tO\n.\tO\n\nSampras\tO\nopens\tO\nthe\tO\ndefence\tO\nof\tO\nhis\tO\nU.S.\tT-1\nOpen\tT-1\ncrown\tT-1\nagainst\tO\nDavid\tO\nRikl\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tT-3\n,\tO\nwhile\tO\ntop-ranked\tT-2\nGraf\tB-PER\nbegins\tT-0\nher\tO\ntitle\tO\ndefence\tO\nagainst\tO\nYayuk\tO\nBasuki\tO\nof\tO\nIndonesia\tO\n.\tO\n\nSampras\tO\nopens\tT-1\nthe\tO\ndefence\tO\nof\tO\nhis\tO\nU.S.\tT-0\nOpen\tT-0\ncrown\tO\nagainst\tO\nDavid\tO\nRikl\tO\nof\tO\nthe\tO\nCzech\tT-2\nRepublic\tT-2\n,\tO\nwhile\tO\ntop-ranked\tO\nGraf\tT-3\nbegins\tO\nher\tO\ntitle\tO\ndefence\tO\nagainst\tO\nYayuk\tB-PER\nBasuki\tI-PER\nof\tO\nIndonesia\tO\n.\tO\n\nSampras\tO\nopens\tT-0\nthe\tO\ndefence\tO\nof\tO\nhis\tO\nU.S.\tO\nOpen\tO\ncrown\tO\nagainst\tO\nDavid\tO\nRikl\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tO\n,\tO\nwhile\tO\ntop-ranked\tO\nGraf\tO\nbegins\tO\nher\tO\ntitle\tO\ndefence\tO\nagainst\tO\nYayuk\tT-1\nBasuki\tT-1\nof\tO\nIndonesia\tB-LOC\n.\tO\n\nWednesday\tT-0\n's\tT-0\nU.S.\tB-MISC\nOpen\tI-MISC\ndraw\tO\nceremony\tO\nrevealed\tT-1\nthat\tO\nboth\tO\ntitle\tO\nholders\tT-2\nshould\tO\nrun\tO\ninto\tO\ntheir\tO\nfirst\tO\nserious\tO\nopposition\tO\nin\tO\nthe\tO\nthird\tO\nround\tO\n.\tO\n\nLooming\tT-1\nin\tO\nSampras\tB-PER\n's\tO\nfuture\tT-2\nis\tO\na\tO\nlikely\tO\nthird-round\tO\ndate\tO\nwith\tO\nrecent\tO\nnemesis\tT-0\nMark\tO\nPhilippoussis\tO\n,\tO\nthe\tO\nrising\tO\nAustralian\tO\nwho\tO\ntook\tO\nout\tO\nSampras\tO\nin\tO\nthe\tO\nthird\tO\nround\tO\nof\tO\nthe\tO\nAustralian\tO\nOpen\tO\nin\tO\nJanuary\tO\n.\tO\n\nLooming\tO\nin\tO\nSampras\tO\n's\tO\nfuture\tT-0\nis\tO\na\tO\nlikely\tO\nthird-round\tO\ndate\tO\nwith\tO\nrecent\tO\nnemesis\tT-1\nMark\tB-PER\nPhilippoussis\tI-PER\n,\tO\nthe\tO\nrising\tT-2\nAustralian\tT-2\nwho\tO\ntook\tT-3\nout\tT-3\nSampras\tO\nin\tO\nthe\tO\nthird\tO\nround\tO\nof\tO\nthe\tO\nAustralian\tO\nOpen\tO\nin\tO\nJanuary\tO\n.\tO\n\nLooming\tO\nin\tO\nSampras\tO\n's\tO\nfuture\tO\nis\tO\na\tO\nlikely\tO\nthird-round\tO\ndate\tO\nwith\tO\nrecent\tO\nnemesis\tO\nMark\tO\nPhilippoussis\tO\n,\tO\nthe\tO\nrising\tT-0\nAustralian\tB-MISC\nwho\tO\ntook\tT-1\nout\tT-1\nSampras\tO\nin\tO\nthe\tO\nthird\tO\nround\tO\nof\tO\nthe\tO\nAustralian\tT-2\nOpen\tT-2\nin\tO\nJanuary\tO\n.\tO\n\nLooming\tO\nin\tO\nSampras\tO\n's\tO\nfuture\tO\nis\tO\na\tO\nlikely\tO\nthird-round\tO\ndate\tO\nwith\tO\nrecent\tO\nnemesis\tO\nMark\tO\nPhilippoussis\tO\n,\tO\nthe\tO\nrising\tO\nAustralian\tT-0\nwho\tO\ntook\tT-1\nout\tT-1\nSampras\tB-PER\nin\tO\nthe\tO\nthird\tO\nround\tO\nof\tO\nthe\tO\nAustralian\tO\nOpen\tO\nin\tO\nJanuary\tO\n.\tO\n\nLooming\tO\nin\tO\nSampras\tO\n's\tO\nfuture\tO\nis\tO\na\tO\nlikely\tO\nthird-round\tO\ndate\tO\nwith\tO\nrecent\tO\nnemesis\tO\nMark\tT-4\nPhilippoussis\tT-4\n,\tO\nthe\tO\nrising\tO\nAustralian\tT-5\nwho\tO\ntook\tO\nout\tO\nSampras\tT-0\nin\tO\nthe\tO\nthird\tT-2\nround\tT-2\nof\tT-2\nthe\tT-2\nAustralian\tB-MISC\nOpen\tI-MISC\nin\tT-3\nJanuary\tT-3\n.\tO\n\nSampras\tB-PER\navenged\tT-0\nthat\tO\ndefeat\tO\nwith\tO\na\tO\nstraight\tO\nsets\tO\nwin\tT-1\nover\tO\nthe\tO\n19-year-old\tO\npower\tO\nhitter\tO\nin\tO\nthe\tO\nsecond\tO\nround\tO\nat\tO\nWimbledon\tO\nand\tO\ntheir\tO\nrubber\tO\nmatch\tO\nin\tO\nNew\tO\nYork\tO\ncould\tO\nprovide\tO\nsome\tO\nfirst-week\tO\nfireworks\tO\n.\tO\n\nSampras\tO\navenged\tO\nthat\tO\ndefeat\tO\nwith\tO\na\tO\nstraight\tO\nsets\tO\nwin\tT-0\nover\tO\nthe\tO\n19-year-old\tO\npower\tO\nhitter\tO\nin\tO\nthe\tO\nsecond\tO\nround\tO\nat\tO\nWimbledon\tB-LOC\nand\tO\ntheir\tO\nrubber\tO\nmatch\tO\nin\tO\nNew\tO\nYork\tO\ncould\tO\nprovide\tO\nsome\tO\nfirst-week\tO\nfireworks\tT-1\n.\tO\n\nSampras\tT-1\navenged\tO\nthat\tO\ndefeat\tO\nwith\tO\na\tO\nstraight\tO\nsets\tO\nwin\tO\nover\tO\nthe\tO\n19-year-old\tO\npower\tO\nhitter\tO\nin\tO\nthe\tO\nsecond\tO\nround\tO\nat\tO\nWimbledon\tO\nand\tO\ntheir\tO\nrubber\tO\nmatch\tT-0\nin\tT-0\nNew\tB-LOC\nYork\tI-LOC\ncould\tO\nprovide\tT-2\nsome\tO\nfirst-week\tO\nfireworks\tO\n.\tO\n\nWhile\tO\nonly\tO\na\tO\nstunning\tO\nupset\tT-1\nwill\tO\nkeep\tO\nGraf\tO\nfrom\tO\nsailing\tO\nthrough\tO\nto\tO\na\tO\npredictable\tO\nsemifinal\tO\nshowdown\tO\nwith\tO\nthird\tO\nseed\tT-2\nArantxa\tB-PER\nSanchez\tI-PER\nVicario\tI-PER\n,\tO\nthe\tO\nGerman\tT-0\nstar\tT-0\ncould\tO\nalso\tO\nbe\tO\ntested\tO\nin\tO\nthe\tO\nthird\tO\nround\tO\nwhere\tO\nshe\tO\nwill\tO\nprobably\tO\nface\tO\n28th-ranked\tO\nveteran\tO\nNatasha\tO\nZvereva\tO\nof\tO\nBelarus\tO\n.\tO\n\nWhile\tO\nonly\tO\na\tO\nstunning\tO\nupset\tO\nwill\tO\nkeep\tO\nGraf\tO\nfrom\tO\nsailing\tO\nthrough\tO\nto\tO\na\tO\npredictable\tO\nsemifinal\tO\nshowdown\tO\nwith\tO\nthird\tO\nseed\tO\nArantxa\tO\nSanchez\tO\nVicario\tO\n,\tO\nthe\tT-0\nGerman\tB-MISC\nstar\tO\ncould\tO\nalso\tO\nbe\tO\ntested\tT-1\nin\tO\nthe\tO\nthird\tO\nround\tO\nwhere\tO\nshe\tO\nwill\tO\nprobably\tO\nface\tO\n28th-ranked\tO\nveteran\tO\nNatasha\tO\nZvereva\tO\nof\tO\nBelarus\tO\n.\tO\n\nWhile\tO\nonly\tO\na\tO\nstunning\tO\nupset\tO\nwill\tO\nkeep\tO\nGraf\tO\nfrom\tO\nsailing\tO\nthrough\tO\nto\tO\na\tO\npredictable\tO\nsemifinal\tO\nshowdown\tO\nwith\tO\nthird\tO\nseed\tO\nArantxa\tO\nSanchez\tO\nVicario\tO\n,\tO\nthe\tO\nGerman\tT-1\nstar\tT-1\ncould\tO\nalso\tO\nbe\tO\ntested\tO\nin\tO\nthe\tO\nthird\tO\nround\tO\nwhere\tT-0\nshe\tO\nwill\tO\nprobably\tO\nface\tO\n28th-ranked\tO\nveteran\tO\nNatasha\tT-2\nZvereva\tT-2\nof\tO\nBelarus\tB-LOC\n.\tO\n\nThere\tO\nwill\tO\nbe\tO\nno\tO\nrepeat\tO\nof\tO\nlast\tO\nyear\tO\n's\tO\nmen\tO\n's\tO\nfinal\tO\nwith\tO\neighth-ranked\tO\nAndre\tB-PER\nAgassi\tI-PER\nlanding\tT-0\nin\tO\nSampras\tO\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nThere\tO\nwill\tO\nbe\tO\nno\tT-1\nrepeat\tT-1\nof\tO\nlast\tO\nyear\tO\n's\tO\nmen\tT-0\n's\tT-0\nfinal\tT-0\nwith\tO\neighth-ranked\tO\nAndre\tO\nAgassi\tO\nlanding\tO\nin\tO\nSampras\tB-PER\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nBumping\tT-2\nAgassi\tB-PER\nup\tO\nto\tO\nthe\tO\nsixth\tO\nseeding\tO\navoided\tO\nthe\tO\npossibility\tO\nthat\tO\nhe\tT-0\nwould\tO\nrun\tO\ninto\tO\nSampras\tT-1\nas\tO\nearly\tO\nas\tO\nthe\tO\nquarter-finals\tO\n,\tO\nbut\tO\nthey\tO\ncould\tO\nlock\tO\nhorns\tO\nin\tO\nthe\tO\nsemis\tO\n.\tO\n\nBumping\tO\nAgassi\tO\nup\tO\nto\tO\nthe\tO\nsixth\tT-2\nseeding\tT-2\navoided\tO\nthe\tO\npossibility\tT-0\nthat\tO\nhe\tO\nwould\tO\nrun\tO\ninto\tT-3\nSampras\tB-PER\nas\tO\nearly\tO\nas\tO\nthe\tO\nquarter-finals\tO\n,\tO\nbut\tO\nthey\tO\ncould\tO\nlock\tT-1\nhorns\tO\nin\tO\nthe\tO\nsemis\tO\n.\tO\n\nOlympic\tB-MISC\nchampion\tO\nAgassi\tO\nmeets\tO\nKarim\tT-0\nAlami\tT-0\nof\tO\nMorocco\tO\nin\tO\nthe\tO\nfirst\tO\nround\tO\n.\tO\n\nOlympic\tO\nchampion\tT-0\nAgassi\tB-PER\nmeets\tO\nKarim\tO\nAlami\tO\nof\tO\nMorocco\tO\nin\tO\nthe\tO\nfirst\tO\nround\tO\n.\tO\n\nOlympic\tO\nchampion\tO\nAgassi\tT-0\nmeets\tT-0\nKarim\tB-PER\nAlami\tI-PER\nof\tT-1\nMorocco\tT-1\nin\tO\nthe\tO\nfirst\tO\nround\tO\n.\tO\n\nOlympic\tO\nchampion\tT-2\nAgassi\tT-1\nmeets\tO\nKarim\tO\nAlami\tO\nof\tO\nMorocco\tB-LOC\nin\tO\nthe\tO\nfirst\tO\nround\tT-0\n.\tO\n\nSurprise\tO\nsecond\tO\nseed\tT-3\nMichael\tB-PER\nChang\tI-PER\n,\tO\nranked\tO\nthird\tO\nin\tO\nthe\tO\nworld\tO\n,\tO\nopens\tO\nagainst\tO\nCzech\tO\nDaniel\tT-0\nVacek\tT-0\n,\tO\nwhile\tO\nwomen\tO\n's\tO\nsecond\tO\nseed\tO\nMonica\tT-1\nSeles\tT-1\ndrew\tO\nAmerican\tO\nAnne\tT-2\nMiller\tT-2\nas\tO\nher\tO\nfirst\tO\nvictim\tO\n.\tO\n\nSurprise\tO\nsecond\tO\nseed\tO\nMichael\tO\nChang\tO\n,\tO\nranked\tO\nthird\tO\nin\tO\nthe\tO\nworld\tO\n,\tO\nopens\tO\nagainst\tT-0\nCzech\tB-MISC\nDaniel\tT-1\nVacek\tT-2\n,\tO\nwhile\tO\nwomen\tT-3\n's\tO\nsecond\tO\nseed\tO\nMonica\tO\nSeles\tO\ndrew\tO\nAmerican\tO\nAnne\tO\nMiller\tO\nas\tO\nher\tO\nfirst\tO\nvictim\tO\n.\tO\n\nSurprise\tO\nsecond\tO\nseed\tO\nMichael\tT-0\nChang\tT-0\n,\tO\nranked\tO\nthird\tO\nin\tO\nthe\tO\nworld\tO\n,\tO\nopens\tO\nagainst\tT-2\nCzech\tO\nDaniel\tB-PER\nVacek\tI-PER\n,\tO\nwhile\tO\nwomen\tO\n's\tO\nsecond\tO\nseed\tO\nMonica\tT-1\nSeles\tT-1\ndrew\tO\nAmerican\tO\nAnne\tO\nMiller\tO\nas\tO\nher\tO\nfirst\tO\nvictim\tO\n.\tO\n\nSurprise\tO\nsecond\tO\nseed\tO\nMichael\tO\nChang\tO\n,\tO\nranked\tO\nthird\tO\nin\tO\nthe\tO\nworld\tO\n,\tO\nopens\tO\nagainst\tO\nCzech\tO\nDaniel\tO\nVacek\tO\n,\tO\nwhile\tO\nwomen\tT-0\n's\tO\nsecond\tO\nseed\tO\nMonica\tB-PER\nSeles\tI-PER\ndrew\tT-1\nAmerican\tO\nAnne\tO\nMiller\tO\nas\tO\nher\tO\nfirst\tO\nvictim\tO\n.\tO\n\nSurprise\tO\nsecond\tT-1\nseed\tT-1\nMichael\tT-0\nChang\tT-0\n,\tO\nranked\tO\nthird\tO\nin\tO\nthe\tO\nworld\tO\n,\tO\nopens\tO\nagainst\tO\nCzech\tO\nDaniel\tO\nVacek\tO\n,\tO\nwhile\tO\nwomen\tT-2\n's\tT-2\nsecond\tO\nseed\tO\nMonica\tO\nSeles\tO\ndrew\tO\nAmerican\tB-MISC\nAnne\tO\nMiller\tO\nas\tO\nher\tO\nfirst\tO\nvictim\tO\n.\tO\n\nSurprise\tO\nsecond\tO\nseed\tT-1\nMichael\tO\nChang\tO\n,\tO\nranked\tO\nthird\tO\nin\tO\nthe\tO\nworld\tO\n,\tO\nopens\tO\nagainst\tO\nCzech\tO\nDaniel\tO\nVacek\tO\n,\tO\nwhile\tO\nwomen\tT-2\n's\tO\nsecond\tO\nseed\tO\nMonica\tO\nSeles\tO\ndrew\tT-0\nAmerican\tT-3\nAnne\tB-PER\nMiller\tI-PER\nas\tO\nher\tO\nfirst\tO\nvictim\tT-4\n.\tO\n\nSecond-ranked\tO\nAustrian\tT-1\nThomas\tB-PER\nMuster\tI-PER\n,\tO\nwho\tT-0\nwas\tO\nseeded\tO\nthird\tO\n,\tO\ndid\tO\nnot\tO\nhave\tO\nthe\tO\nluck\tO\nof\tO\nthe\tO\ndraw\tO\nwith\tO\nhim\tO\n.\tO\n\nIn\tO\nthe\tO\nfirst\tO\nround\tO\nMuster\tB-PER\nfaces\tT-0\nAmerican\tO\nRichey\tO\nReneberg\tO\n,\tO\nwho\tO\nhas\tO\nbeen\tO\nplaying\tT-1\nsome\tO\nof\tO\nthe\tO\nbest\tO\ntennis\tT-2\nof\tO\nhis\tO\ncareer\tO\nof\tO\nlate\tO\n.\tO\n\nIn\tO\nthe\tO\nfirst\tO\nround\tO\nMuster\tT-0\nfaces\tO\nAmerican\tB-MISC\nRichey\tO\nReneberg\tO\n,\tO\nwho\tO\nhas\tO\nbeen\tO\nplaying\tT-1\nsome\tO\nof\tO\nthe\tO\nbest\tT-2\ntennis\tO\nof\tO\nhis\tO\ncareer\tO\nof\tO\nlate\tO\n.\tO\n\nIn\tT-2\nthe\tT-2\nfirst\tT-2\nround\tT-2\nMuster\tT-2\nfaces\tT-2\nAmerican\tT-2\nRichey\tB-PER\nReneberg\tI-PER\n,\tO\nwho\tT-0\nhas\tO\nbeen\tO\nplaying\tO\nsome\tO\nof\tO\nthe\tO\nbest\tO\ntennis\tO\nof\tO\nhis\tT-1\ncareer\tO\nof\tO\nlate\tO\n.\tO\n\nIf\tO\nhe\tO\nsurvives\tT-0\n,\tO\nMuster\tB-PER\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\neither\tO\nfifth-seeded\tT-1\nWimbledon\tO\nchampion\tO\nRichard\tO\nKrajicek\tO\nof\tO\nthe\tO\nNetherlands\tO\nor\tO\n12th-seeded\tO\nAmerican\tO\nTodd\tO\nMartin\tO\nin\tO\nthe\tO\nquarter-finals\tO\nin\tO\nChang\tO\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nIf\tO\nhe\tO\nsurvives\tO\n,\tO\nMuster\tO\nis\tO\nseeded\tT-0\nto\tO\nrun\tO\ninto\tO\neither\tO\nfifth-seeded\tT-2\nWimbledon\tB-MISC\nchampion\tT-1\nRichard\tO\nKrajicek\tO\nof\tO\nthe\tO\nNetherlands\tO\nor\tO\n12th-seeded\tO\nAmerican\tO\nTodd\tO\nMartin\tO\nin\tO\nthe\tO\nquarter-finals\tO\nin\tO\nChang\tO\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nIf\tO\nhe\tO\nsurvives\tO\n,\tO\nMuster\tT-0\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\neither\tO\nfifth-seeded\tO\nWimbledon\tO\nchampion\tT-1\nRichard\tB-PER\nKrajicek\tI-PER\nof\tO\nthe\tO\nNetherlands\tO\nor\tO\n12th-seeded\tO\nAmerican\tO\nTodd\tO\nMartin\tO\nin\tO\nthe\tO\nquarter-finals\tO\nin\tO\nChang\tO\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nIf\tO\nhe\tO\nsurvives\tO\n,\tO\nMuster\tT-1\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\neither\tO\nfifth-seeded\tO\nWimbledon\tT-2\nchampion\tO\nRichard\tO\nKrajicek\tO\nof\tO\nthe\tO\nNetherlands\tB-LOC\nor\tO\n12th-seeded\tO\nAmerican\tO\nTodd\tO\nMartin\tO\nin\tO\nthe\tO\nquarter-finals\tT-0\nin\tO\nChang\tO\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nIf\tO\nhe\tO\nsurvives\tT-1\n,\tO\nMuster\tO\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\neither\tO\nfifth-seeded\tO\nWimbledon\tO\nchampion\tO\nRichard\tO\nKrajicek\tO\nof\tO\nthe\tO\nNetherlands\tO\nor\tO\n12th-seeded\tT-2\nAmerican\tB-MISC\nTodd\tO\nMartin\tO\nin\tO\nthe\tO\nquarter-finals\tO\nin\tO\nChang\tO\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tT-2\n\nIf\tO\nhe\tO\nsurvives\tO\n,\tO\nMuster\tT-1\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\neither\tO\nfifth-seeded\tO\nWimbledon\tO\nchampion\tO\nRichard\tT-2\nKrajicek\tT-2\nof\tO\nthe\tT-3\nNetherlands\tT-3\nor\tO\n12th-seeded\tT-0\nAmerican\tT-0\nTodd\tB-PER\nMartin\tI-PER\nin\tO\nthe\tO\nquarter-finals\tO\nin\tO\nChang\tO\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nIf\tO\nhe\tO\nsurvives\tT-3\n,\tO\nMuster\tT-0\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\neither\tO\nfifth-seeded\tO\nWimbledon\tO\nchampion\tT-5\nRichard\tT-1\nKrajicek\tT-1\nof\tO\nthe\tO\nNetherlands\tT-4\nor\tO\n12th-seeded\tO\nAmerican\tT-6\nTodd\tT-2\nMartin\tT-2\nin\tO\nthe\tO\nquarter-finals\tO\nin\tO\nChang\tB-PER\n's\tO\nhalf\tO\nof\tO\nthe\tO\ndraw\tO\n.\tO\n\nPerhaps\tO\nthe\tO\nbest\tO\n,\tO\nyet\tO\nmost\tO\nunfortunate\tO\n,\tO\nfirst-round\tT-3\nmatchup\tT-3\nof\tO\nthe\tO\nmen\tT-4\n's\tT-4\ncompetition\tT-4\npits\tO\neighth\tT-5\nseed\tT-5\nJim\tB-PER\nCourier\tI-PER\nagainst\tT-1\nretiring\tO\nstar\tO\nStefan\tT-2\nEdberg\tT-2\n.\tO\n\nPerhaps\tO\nthe\tT-1\nbest\tT-1\n,\tO\nyet\tO\nmost\tO\nunfortunate\tO\n,\tO\nfirst-round\tO\nmatchup\tO\nof\tO\nthe\tO\nmen\tO\n's\tO\ncompetition\tT-2\npits\tO\neighth\tO\nseed\tO\nJim\tO\nCourier\tO\nagainst\tO\nretiring\tT-0\nstar\tT-0\nStefan\tB-PER\nEdberg\tI-PER\n.\tO\n\nThe\tO\npopular\tT-1\nSwede\tB-MISC\nis\tO\nplaying\tT-2\nhis\tO\nfinal\tT-0\nmajor\tO\ntournament\tO\nnext\tO\nweek\tO\nand\tO\nthe\tO\ntwo-time\tT-3\nchampion\tT-3\n's\tO\nGrand\tO\nSlam\tO\nfarewell\tO\ncould\tO\nwell\tO\nbe\tO\na\tO\none-match\tO\naffair\tO\n.\tT-0\n\nThe\tO\npopular\tO\nSwede\tT-1\nis\tO\nplaying\tO\nhis\tO\nfinal\tO\nmajor\tO\ntournament\tO\nnext\tO\nweek\tO\nand\tO\nthe\tO\ntwo-time\tO\nchampion\tO\n's\tO\nGrand\tB-MISC\nSlam\tI-MISC\nfarewell\tT-0\ncould\tO\nwell\tO\nbe\tO\na\tO\none-match\tO\naffair\tO\n.\tO\n\nWith\tO\nthe\tO\nexception\tO\nof\tO\na\tO\nPhilippoussis\tB-PER\nshowdown\tT-3\n,\tO\nSampras\tT-0\nlooks\tO\nto\tO\nhave\tO\nlanded\tT-1\nin\tO\na\tO\ncomfortable\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nwith\tO\nthe\tO\nlikes\tO\nof\tO\nFrenchman\tO\nCedric\tO\nPioline\tO\nand\tO\nailing\tO\nFrench\tO\nOpen\tO\nchampion\tO\nYevgeny\tO\nKafelnikov\tO\n,\tO\nwho\tO\nis\tO\nnursing\tO\na\tO\nrib\tO\ninjury\tT-2\n,\tO\nin\tO\nhis\tO\npath\tO\n.\tO\n\nWith\tO\nthe\tO\nexception\tT-5\nof\tO\na\tO\nPhilippoussis\tO\nshowdown\tO\n,\tO\nSampras\tB-PER\nlooks\tO\nto\tO\nhave\tO\nlanded\tT-0\nin\tO\na\tO\ncomfortable\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nwith\tO\nthe\tO\nlikes\tO\nof\tO\nFrenchman\tO\nCedric\tT-3\nPioline\tT-3\nand\tO\nailing\tT-1\nFrench\tO\nOpen\tO\nchampion\tO\nYevgeny\tT-4\nKafelnikov\tT-4\n,\tO\nwho\tO\nis\tO\nnursing\tT-2\na\tO\nrib\tO\ninjury\tO\n,\tO\nin\tO\nhis\tO\npath\tO\n.\tO\n\nWith\tO\nthe\tO\nexception\tO\nof\tO\na\tO\nPhilippoussis\tO\nshowdown\tO\n,\tO\nSampras\tO\nlooks\tO\nto\tO\nhave\tO\nlanded\tO\nin\tO\na\tO\ncomfortable\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nwith\tO\nthe\tO\nlikes\tO\nof\tO\nFrenchman\tB-MISC\nCedric\tT-0\nPioline\tT-0\nand\tO\nailing\tO\nFrench\tO\nOpen\tO\nchampion\tT-1\nYevgeny\tO\nKafelnikov\tO\n,\tO\nwho\tO\nis\tO\nnursing\tO\na\tO\nrib\tO\ninjury\tO\n,\tO\nin\tO\nhis\tO\npath\tO\n.\tO\n\nWith\tO\nthe\tO\nexception\tO\nof\tO\na\tO\nPhilippoussis\tT-2\nshowdown\tO\n,\tO\nSampras\tO\nlooks\tO\nto\tO\nhave\tO\nlanded\tO\nin\tO\na\tO\ncomfortable\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nwith\tO\nthe\tO\nlikes\tT-0\nof\tT-0\nFrenchman\tT-3\nCedric\tB-PER\nPioline\tI-PER\nand\tO\nailing\tO\nFrench\tO\nOpen\tT-4\nchampion\tT-4\nYevgeny\tO\nKafelnikov\tO\n,\tO\nwho\tO\nis\tO\nnursing\tO\na\tO\nrib\tO\ninjury\tO\n,\tO\nin\tO\nhis\tO\npath\tO\n.\tO\n\nWith\tO\nthe\tO\nexception\tT-1\nof\tO\na\tO\nPhilippoussis\tO\nshowdown\tO\n,\tO\nSampras\tO\nlooks\tO\nto\tO\nhave\tO\nlanded\tT-2\nin\tO\na\tO\ncomfortable\tT-4\nquarter\tT-4\nof\tO\nthe\tO\ndraw\tO\nwith\tO\nthe\tO\nlikes\tO\nof\tO\nFrenchman\tO\nCedric\tO\nPioline\tO\nand\tO\nailing\tT-0\nFrench\tB-MISC\nOpen\tI-MISC\nchampion\tT-3\nYevgeny\tO\nKafelnikov\tO\n,\tO\nwho\tO\nis\tO\nnursing\tT-5\na\tO\nrib\tO\ninjury\tO\n,\tO\nin\tO\nhis\tO\npath\tO\n.\tO\n\nWith\tO\nthe\tO\nexception\tO\nof\tO\na\tO\nPhilippoussis\tO\nshowdown\tO\n,\tO\nSampras\tO\nlooks\tO\nto\tO\nhave\tO\nlanded\tT-0\nin\tO\na\tO\ncomfortable\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nwith\tO\nthe\tO\nlikes\tO\nof\tO\nFrenchman\tO\nCedric\tO\nPioline\tO\nand\tO\nailing\tO\nFrench\tO\nOpen\tO\nchampion\tO\nYevgeny\tB-PER\nKafelnikov\tI-PER\n,\tO\nwho\tT-1\nis\tO\nnursing\tO\na\tO\nrib\tO\ninjury\tO\n,\tO\nin\tO\nhis\tO\npath\tO\n.\tO\n\nSeles\tB-PER\n,\tO\nrunner-up\tO\nto\tO\nGraf\tT-5\nlast\tO\nyear\tO\n,\tO\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\nfifth-ranked\tO\nGerman\tT-3\nAnke\tT-3\nHuber\tT-3\nin\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nfourth\tO\nseed\tO\nConchita\tT-4\nMartinez\tT-4\nor\tO\neighth-seeded\tT-0\nOlympic\tT-1\nchampion\tO\nLindsay\tT-2\nDavenport\tT-2\nlooking\tO\nlike\tO\nher\tO\nmost\tO\nlikely\tO\nsemifinal\tO\nopponents\tO\n.\tT-0\n\nSeles\tT-3\n,\tO\nrunner-up\tT-1\nto\tO\nGraf\tB-PER\nlast\tO\nyear\tO\n,\tO\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\nfifth-ranked\tO\nGerman\tO\nAnke\tO\nHuber\tO\nin\tO\nthe\tO\nquarter-finals\tT-2\nwith\tO\nfourth\tO\nseed\tO\nConchita\tT-0\nMartinez\tO\nor\tO\neighth-seeded\tO\nOlympic\tO\nchampion\tO\nLindsay\tO\nDavenport\tO\nlooking\tO\nlike\tO\nher\tO\nmost\tO\nlikely\tO\nsemifinal\tO\nopponents\tO\n.\tO\n\nSeles\tO\n,\tO\nrunner-up\tT-0\nto\tO\nGraf\tT-1\nlast\tO\nyear\tO\n,\tO\nis\tT-2\nseeded\tT-2\nto\tT-2\nrun\tT-2\ninto\tT-2\nfifth-ranked\tT-2\nGerman\tB-MISC\nAnke\tO\nHuber\tO\nin\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nfourth\tO\nseed\tO\nConchita\tO\nMartinez\tO\nor\tO\neighth-seeded\tO\nOlympic\tO\nchampion\tO\nLindsay\tO\nDavenport\tO\nlooking\tO\nlike\tO\nher\tO\nmost\tO\nlikely\tO\nsemifinal\tO\nopponents\tO\n.\tT-0\n\nSeles\tT-1\n,\tO\nrunner-up\tO\nto\tO\nGraf\tO\nlast\tO\nyear\tO\n,\tO\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\nfifth-ranked\tT-0\nGerman\tT-3\nAnke\tB-PER\nHuber\tI-PER\nin\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nfourth\tO\nseed\tO\nConchita\tO\nMartinez\tT-2\nor\tO\neighth-seeded\tO\nOlympic\tO\nchampion\tO\nLindsay\tO\nDavenport\tO\nlooking\tO\nlike\tO\nher\tO\nmost\tO\nlikely\tO\nsemifinal\tO\nopponents\tO\n.\tT-2\n\nSeles\tO\n,\tO\nrunner-up\tT-0\nto\tO\nGraf\tO\nlast\tO\nyear\tO\n,\tO\nis\tO\nseeded\tO\nto\tO\nrun\tT-2\ninto\tO\nfifth-ranked\tO\nGerman\tO\nAnke\tO\nHuber\tO\nin\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nfourth\tT-4\nseed\tT-4\nConchita\tB-PER\nMartinez\tI-PER\nor\tO\neighth-seeded\tO\nOlympic\tO\nchampion\tO\nLindsay\tO\nDavenport\tO\nlooking\tO\nlike\tO\nher\tT-3\nmost\tT-3\nlikely\tT-3\nsemifinal\tO\nopponents\tT-1\n.\tO\n\nSeles\tO\n,\tO\nrunner-up\tO\nto\tO\nGraf\tO\nlast\tO\nyear\tO\n,\tO\nis\tO\nseeded\tO\nto\tO\nrun\tO\ninto\tO\nfifth-ranked\tO\nGerman\tO\nAnke\tO\nHuber\tO\nin\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nfourth\tO\nseed\tO\nConchita\tO\nMartinez\tO\nor\tO\neighth-seeded\tT-0\nOlympic\tB-MISC\nchampion\tO\nLindsay\tT-1\nDavenport\tT-2\nlooking\tO\nlike\tO\nher\tO\nmost\tO\nlikely\tO\nsemifinal\tO\nopponents\tO\n.\tO\n\nSeles\tO\n,\tO\nrunner-up\tO\nto\tO\nGraf\tO\nlast\tO\nyear\tO\n,\tO\nis\tO\nseeded\tT-0\nto\tO\nrun\tO\ninto\tO\nfifth-ranked\tO\nGerman\tO\nAnke\tO\nHuber\tO\nin\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nfourth\tO\nseed\tO\nConchita\tO\nMartinez\tO\nor\tO\neighth-seeded\tO\nOlympic\tO\nchampion\tO\nLindsay\tB-PER\nDavenport\tI-PER\nlooking\tO\nlike\tO\nher\tO\nmost\tO\nlikely\tO\nsemifinal\tO\nopponents\tO\n.\tO\n\nBut\tO\nHuber\tB-PER\nwill\tT-0\nbe\tO\ntested\tT-1\nimmediately\tO\nwith\tO\na\tO\nfirst-round\tO\nencounter\tO\nagainst\tT-2\ndangerous\tO\n18th-ranked\tO\nSouth\tO\nAfrican\tO\nAmanda\tO\nCoetzer\tO\n.\tO\n\nBut\tO\nHuber\tO\nwill\tO\nbe\tO\ntested\tO\nimmediately\tO\nwith\tO\na\tO\nfirst-round\tT-0\nencounter\tT-0\nagainst\tO\ndangerous\tT-1\n18th-ranked\tO\nSouth\tB-MISC\nAfrican\tI-MISC\nAmanda\tO\nCoetzer\tO\n.\tO\n\nBut\tO\nHuber\tO\nwill\tO\nbe\tO\ntested\tO\nimmediately\tO\nwith\tO\na\tO\nfirst-round\tO\nencounter\tO\nagainst\tO\ndangerous\tT-0\n18th-ranked\tO\nSouth\tO\nAfrican\tO\nAmanda\tB-PER\nCoetzer\tI-PER\n.\tO\n\nSanchez\tB-PER\nVicario\tI-PER\n,\tO\nrunner-up\tT-0\nto\tO\nGraf\tO\nat\tO\nthe\tO\nFrench\tO\nOpen\tO\nand\tO\nWimbledon\tO\n,\tO\nbegins\tO\nplay\tO\nagainst\tO\na\tO\nqualifier\tO\nin\tO\na\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nthat\tO\nincludes\tO\nyoung\tO\ntalent\tO\nMartina\tO\nHingis\tO\n,\tO\nthe\tO\n16th\tO\nseed\tO\n,\tO\nbefore\tO\na\tO\nprobable\tO\nquarter-final\tO\nclash\tO\nwith\tO\nseventh-seeded\tO\nveteran\tO\nJana\tO\nNovotna\tO\n.\tO\n\nSanchez\tT-3\nVicario\tT-3\n,\tO\nrunner-up\tT-2\nto\tT-2\nGraf\tB-PER\nat\tO\nthe\tO\nFrench\tO\nOpen\tO\nand\tO\nWimbledon\tO\n,\tO\nbegins\tT-0\nplay\tO\nagainst\tO\na\tO\nqualifier\tO\nin\tO\na\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tT-1\nthat\tO\nincludes\tO\nyoung\tO\ntalent\tO\nMartina\tO\nHingis\tO\n,\tO\nthe\tO\n16th\tO\nseed\tO\n,\tO\nbefore\tO\na\tO\nprobable\tO\nquarter-final\tO\nclash\tO\nwith\tO\nseventh-seeded\tO\nveteran\tO\nJana\tO\nNovotna\tO\n.\tO\n\nSanchez\tT-2\nVicario\tT-2\n,\tO\nrunner-up\tT-0\nto\tT-0\nGraf\tT-0\nat\tT-0\nthe\tT-0\nFrench\tB-MISC\nOpen\tI-MISC\nand\tO\nWimbledon\tT-3\n,\tO\nbegins\tO\nplay\tO\nagainst\tO\na\tO\nqualifier\tT-1\nin\tO\na\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nthat\tO\nincludes\tO\nyoung\tO\ntalent\tO\nMartina\tO\nHingis\tO\n,\tO\nthe\tO\n16th\tO\nseed\tO\n,\tO\nbefore\tO\na\tO\nprobable\tO\nquarter-final\tT-4\nclash\tT-4\nwith\tO\nseventh-seeded\tO\nveteran\tO\nJana\tO\nNovotna\tO\n.\tO\n\nSanchez\tO\nVicario\tO\n,\tO\nrunner-up\tT-1\nto\tO\nGraf\tO\nat\tO\nthe\tO\nFrench\tO\nOpen\tO\nand\tO\nWimbledon\tB-MISC\n,\tO\nbegins\tT-2\nplay\tO\nagainst\tO\na\tO\nqualifier\tO\nin\tO\na\tO\nquarter\tT-0\nof\tO\nthe\tO\ndraw\tO\nthat\tO\nincludes\tO\nyoung\tO\ntalent\tO\nMartina\tO\nHingis\tO\n,\tO\nthe\tO\n16th\tO\nseed\tO\n,\tO\nbefore\tO\na\tO\nprobable\tO\nquarter-final\tO\nclash\tO\nwith\tO\nseventh-seeded\tO\nveteran\tO\nJana\tO\nNovotna\tO\n.\tT-1\n\nSanchez\tO\nVicario\tO\n,\tO\nrunner-up\tO\nto\tO\nGraf\tO\nat\tO\nthe\tO\nFrench\tO\nOpen\tO\nand\tO\nWimbledon\tO\n,\tO\nbegins\tO\nplay\tT-2\nagainst\tO\na\tO\nqualifier\tO\nin\tO\na\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nthat\tO\nincludes\tO\nyoung\tO\ntalent\tO\nMartina\tB-PER\nHingis\tI-PER\n,\tO\nthe\tO\n16th\tT-0\nseed\tT-1\n,\tO\nbefore\tO\na\tO\nprobable\tO\nquarter-final\tO\nclash\tO\nwith\tO\nseventh-seeded\tO\nveteran\tO\nJana\tO\nNovotna\tO\n.\tO\n\nSanchez\tT-0\nVicario\tT-0\n,\tO\nrunner-up\tO\nto\tO\nGraf\tO\nat\tO\nthe\tO\nFrench\tO\nOpen\tO\nand\tO\nWimbledon\tO\n,\tO\nbegins\tO\nplay\tT-1\nagainst\tT-1\na\tT-1\nqualifier\tT-1\nin\tO\na\tO\nquarter\tO\nof\tO\nthe\tO\ndraw\tO\nthat\tO\nincludes\tO\nyoung\tO\ntalent\tO\nMartina\tO\nHingis\tO\n,\tO\nthe\tO\n16th\tO\nseed\tO\n,\tO\nbefore\tO\na\tO\nprobable\tO\nquarter-final\tO\nclash\tO\nwith\tO\nseventh-seeded\tO\nveteran\tT-2\nJana\tB-PER\nNovotna\tI-PER\n.\tO\n\nMartinez\tB-PER\nbegins\tT-1\nplay\tT-2\nagainst\tT-2\nRuxandra\tO\nDragomir\tO\nof\tO\nRomania\tT-0\n.\tO\n\nMartinez\tT-1\nbegins\tO\nplay\tO\nagainst\tT-0\nRuxandra\tB-PER\nDragomir\tI-PER\nof\tO\nRomania\tO\n.\tO\n\nMartinez\tO\nbegins\tO\nplay\tT-1\nagainst\tT-1\nRuxandra\tT-0\nDragomir\tT-0\nof\tT-2\nRomania\tB-LOC\n.\tO\n\nRTRS\tB-ORG\n-\tO\nTennis\tT-1\n-\tO\nMuster\tT-2\nupset\tO\n,\tO\nPhilippoussis\tT-3\nwins\tT-0\n,\tO\nStoltenberg\tT-4\nloses\tO\n.\tO\n\nRTRS\tO\n-\tO\nTennis\tO\n-\tO\nMuster\tT-0\nupset\tO\n,\tO\nPhilippoussis\tB-PER\nwins\tT-1\n,\tO\nStoltenberg\tO\nloses\tO\n.\tO\n\nRTRS\tT-3\n-\tO\nTennis\tO\n-\tO\nMuster\tO\nupset\tT-0\n,\tO\nPhilippoussis\tO\nwins\tT-1\n,\tO\nStoltenberg\tB-PER\nloses\tT-2\n.\tO\n\nTop-seeded\tO\nThomas\tB-PER\nMuster\tI-PER\nof\tO\nAustria\tO\nwas\tO\nbeaten\tT-0\n6-3\tO\n7-5\tO\nby\tO\n123rd-ranked\tO\nDaniel\tO\nNestor\tO\nof\tO\nCanada\tO\non\tO\nWednesday\tO\nin\tT-2\nhis\tT-2\nfirst\tT-2\nmatch\tT-2\nof\tO\nthe\tO\n$\tO\n2\tO\nmillion\tO\nCanadian\tT-1\nOpen\tT-1\n.\tO\n\nTop-seeded\tO\nThomas\tO\nMuster\tO\nof\tO\nAustria\tB-LOC\nwas\tO\nbeaten\tT-0\n6-3\tO\n7-5\tO\nby\tO\n123rd-ranked\tO\nDaniel\tO\nNestor\tO\nof\tO\nCanada\tO\non\tO\nWednesday\tO\nin\tO\nhis\tO\nfirst\tO\nmatch\tT-2\nof\tO\nthe\tO\n$\tO\n2\tO\nmillion\tO\nCanadian\tT-1\nOpen\tT-1\n.\tO\n\nTop-seeded\tO\nThomas\tT-2\nMuster\tT-3\nof\tO\nAustria\tO\nwas\tO\nbeaten\tT-0\n6-3\tO\n7-5\tO\nby\tO\n123rd-ranked\tO\nDaniel\tB-PER\nNestor\tI-PER\nof\tO\nCanada\tO\non\tO\nWednesday\tO\nin\tO\nhis\tO\nfirst\tO\nmatch\tO\nof\tO\nthe\tO\n$\tO\n2\tO\nmillion\tO\nCanadian\tT-1\nOpen\tT-1\n.\tO\n\nTop-seeded\tO\nThomas\tT-0\nMuster\tT-0\nof\tO\nAustria\tO\nwas\tO\nbeaten\tO\n6-3\tO\n7-5\tO\nby\tO\n123rd-ranked\tO\nDaniel\tO\nNestor\tO\nof\tO\nCanada\tB-LOC\non\tO\nWednesday\tO\nin\tO\nhis\tO\nfirst\tO\nmatch\tO\nof\tO\nthe\tO\n$\tO\n2\tO\nmillion\tO\nCanadian\tO\nOpen\tO\n.\tO\n\nTop-seeded\tO\nThomas\tT-1\nMuster\tO\nof\tO\nAustria\tO\nwas\tO\nbeaten\tO\n6-3\tO\n7-5\tO\nby\tO\n123rd-ranked\tO\nDaniel\tO\nNestor\tO\nof\tO\nCanada\tO\non\tO\nWednesday\tO\nin\tO\nhis\tO\nfirst\tO\nmatch\tO\nof\tO\nthe\tO\n$\tO\n2\tT-0\nmillion\tT-0\nCanadian\tB-MISC\nOpen\tI-MISC\n.\tT-1\n\nA\tT-0\nlefthander\tT-0\nwith\tT-0\na\tT-0\nstrong\tT-0\nserve\tT-0\n,\tO\nNestor\tB-PER\nkept\tT-2\nthe\tO\nrallies\tO\nshort\tO\nby\tO\nconstantly\tO\nattacking\tT-3\nthe\tO\nnet\tO\nand\tO\nthe\tO\ntactic\tO\nworked\tT-1\nin\tO\nthe\tO\nsecond-round\tO\nmatch\tO\nagainst\tO\nMuster\tO\n,\tO\nplaying\tT-4\nhis\tO\nfirst\tO\nmatch\tO\nafter\tO\nreceiving\tO\na\tO\nfirst-round\tO\nbye\tO\nalong\tO\nwith\tO\nthe\tO\nother\tO\ntop\tO\neight\tO\nseeds\tO\n.\tO\n\nA\tO\nlefthander\tO\nwith\tO\na\tO\nstrong\tO\nserve\tO\n,\tO\nNestor\tT-1\nkept\tO\nthe\tO\nrallies\tO\nshort\tO\nby\tO\nconstantly\tO\nattacking\tO\nthe\tO\nnet\tO\nand\tO\nthe\tO\ntactic\tT-2\nworked\tO\nin\tO\nthe\tO\nsecond-round\tO\nmatch\tO\nagainst\tT-0\nMuster\tB-PER\n,\tO\nplaying\tO\nhis\tO\nfirst\tO\nmatch\tO\nafter\tO\nreceiving\tO\na\tO\nfirst-round\tO\nbye\tO\nalong\tO\nwith\tO\nthe\tO\nother\tO\ntop\tO\neight\tO\nseeds\tO\n.\tO\n\nThe\tO\ntournament\tO\nalso\tO\nlost\tO\nits\tO\nsecond\tT-2\nseed\tT-2\non\tO\nthe\tO\nthird\tO\nday\tO\nof\tO\nplay\tO\nwhen\tO\nsecond-seeded\tT-0\nGoran\tB-PER\nIvanisevic\tI-PER\nof\tO\nCroatia\tO\nwas\tO\nbeaten\tO\n6-7(3-7\tO\n)\tO\n6-4\tO\n6-4\tO\nby\tO\nunseeded\tT-1\nMikael\tO\nTillstrom\tO\nof\tO\nSweden\tO\n.\tO\n\nThe\tO\ntournament\tT-0\nalso\tO\nlost\tO\nits\tO\nsecond\tO\nseed\tO\non\tO\nthe\tO\nthird\tO\nday\tO\nof\tO\nplay\tO\nwhen\tO\nsecond-seeded\tO\nGoran\tO\nIvanisevic\tO\nof\tT-2\nCroatia\tB-LOC\nwas\tO\nbeaten\tT-1\n6-7(3-7\tO\n)\tO\n6-4\tO\n6-4\tO\nby\tO\nunseeded\tO\nMikael\tO\nTillstrom\tO\nof\tO\nSweden\tO\n.\tO\n\nThe\tO\ntournament\tO\nalso\tO\nlost\tO\nits\tO\nsecond\tT-1\nseed\tT-1\non\tO\nthe\tO\nthird\tO\nday\tO\nof\tO\nplay\tO\nwhen\tO\nsecond-seeded\tO\nGoran\tT-2\nIvanisevic\tT-2\nof\tO\nCroatia\tO\nwas\tO\nbeaten\tO\n6-7(3-7\tO\n)\tO\n6-4\tO\n6-4\tO\nby\tO\nunseeded\tO\nMikael\tB-PER\nTillstrom\tI-PER\nof\tO\nSweden\tT-0\n.\tO\n\nThe\tO\ntournament\tO\nalso\tO\nlost\tO\nits\tO\nsecond\tO\nseed\tO\non\tO\nthe\tO\nthird\tO\nday\tO\nof\tO\nplay\tO\nwhen\tO\nsecond-seeded\tO\nGoran\tT-0\nIvanisevic\tT-0\nof\tO\nCroatia\tO\nwas\tO\nbeaten\tT-2\n6-7(3-7\tO\n)\tO\n6-4\tO\n6-4\tO\nby\tO\nunseeded\tO\nMikael\tO\nTillstrom\tO\nof\tT-1\nSweden\tB-LOC\n.\tO\n\nOther\tO\nseeded\tO\nplayers\tO\nadvancing\tT-2\nwere\tO\nnumber\tT-0\nthree\tT-0\nWayne\tB-PER\nFerreira\tI-PER\nof\tT-1\nSouth\tT-1\nAfrica\tT-1\n,\tO\nnumber\tO\nfour\tO\nMarcelo\tO\nRios\tO\nof\tO\nChile\tO\n,\tO\nnumber\tO\nsix\tO\nMaliVai\tO\nWashington\tO\nof\tO\nthe\tO\nUnited\tO\nStates\tO\nand\tO\nAmerican\tO\nTodd\tO\nMartin\tO\n,\tO\nthe\tO\nseventh\tO\nseeed\tO\n.\tO\n\nOther\tO\nseeded\tT-4\nplayers\tO\nadvancing\tT-3\nwere\tO\nnumber\tO\nthree\tO\nWayne\tT-0\nFerreira\tT-0\nof\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n,\tO\nnumber\tO\nfour\tO\nMarcelo\tO\nRios\tO\nof\tO\nChile\tO\n,\tO\nnumber\tO\nsix\tO\nMaliVai\tO\nWashington\tO\nof\tO\nthe\tO\nUnited\tT-1\nStates\tT-1\nand\tO\nAmerican\tT-2\nTodd\tO\nMartin\tO\n,\tO\nthe\tO\nseventh\tO\nseeed\tO\n.\tO\n\nOther\tO\nseeded\tO\nplayers\tO\nadvancing\tO\nwere\tO\nnumber\tO\nthree\tO\nWayne\tO\nFerreira\tO\nof\tO\nSouth\tO\nAfrica\tO\n,\tO\nnumber\tO\nfour\tO\nMarcelo\tB-PER\nRios\tI-PER\nof\tO\nChile\tT-0\n,\tO\nnumber\tO\nsix\tO\nMaliVai\tO\nWashington\tO\nof\tO\nthe\tO\nUnited\tO\nStates\tO\nand\tO\nAmerican\tO\nTodd\tO\nMartin\tO\n,\tO\nthe\tO\nseventh\tO\nseeed\tO\n.\tO\n\nOther\tO\nseeded\tO\nplayers\tO\nadvancing\tT-3\nwere\tO\nnumber\tO\nthree\tO\nWayne\tO\nFerreira\tO\nof\tO\nSouth\tT-1\nAfrica\tT-1\n,\tO\nnumber\tO\nfour\tO\nMarcelo\tT-0\nRios\tT-0\nof\tO\nChile\tB-LOC\n,\tO\nnumber\tO\nsix\tO\nMaliVai\tO\nWashington\tO\nof\tO\nthe\tO\nUnited\tT-2\nStates\tT-2\nand\tO\nAmerican\tO\nTodd\tO\nMartin\tO\n,\tO\nthe\tO\nseventh\tO\nseeed\tO\n.\tO\n\nOther\tO\nseeded\tO\nplayers\tT-1\nadvancing\tO\nwere\tO\nnumber\tO\nthree\tT-0\nWayne\tT-0\nFerreira\tO\nof\tO\nSouth\tO\nAfrica\tO\n,\tO\nnumber\tO\nfour\tO\nMarcelo\tO\nRios\tO\nof\tO\nChile\tO\n,\tO\nnumber\tO\nsix\tO\nMaliVai\tB-PER\nWashington\tI-PER\nof\tO\nthe\tO\nUnited\tO\nStates\tO\nand\tO\nAmerican\tO\nTodd\tO\nMartin\tO\n,\tO\nthe\tO\nseventh\tO\nseeed\tO\n.\tO\n\nOther\tO\nseeded\tO\nplayers\tO\nadvancing\tT-0\nwere\tO\nnumber\tO\nthree\tO\nWayne\tO\nFerreira\tT-1\nof\tO\nSouth\tO\nAfrica\tO\n,\tO\nnumber\tO\nfour\tO\nMarcelo\tO\nRios\tO\nof\tO\nChile\tO\n,\tO\nnumber\tO\nsix\tO\nMaliVai\tO\nWashington\tO\nof\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\nand\tO\nAmerican\tO\nTodd\tO\nMartin\tO\n,\tO\nthe\tO\nseventh\tO\nseeed\tT-2\n.\tO\n\nOther\tO\nseeded\tT-2\nplayers\tO\nadvancing\tT-1\nwere\tO\nnumber\tO\nthree\tO\nWayne\tO\nFerreira\tO\nof\tO\nSouth\tO\nAfrica\tO\n,\tO\nnumber\tO\nfour\tO\nMarcelo\tO\nRios\tO\nof\tO\nChile\tO\n,\tO\nnumber\tO\nsix\tO\nMaliVai\tO\nWashington\tO\nof\tO\nthe\tO\nUnited\tO\nStates\tO\nand\tO\nAmerican\tB-MISC\nTodd\tO\nMartin\tO\n,\tO\nthe\tO\nseventh\tT-0\nseeed\tT-0\n.\tO\n\nOther\tO\nseeded\tT-2\nplayers\tT-2\nadvancing\tO\nwere\tO\nnumber\tO\nthree\tO\nWayne\tO\nFerreira\tO\nof\tO\nSouth\tO\nAfrica\tO\n,\tO\nnumber\tO\nfour\tO\nMarcelo\tO\nRios\tO\nof\tO\nChile\tO\n,\tO\nnumber\tO\nsix\tO\nMaliVai\tO\nWashington\tO\nof\tO\nthe\tO\nUnited\tT-0\nStates\tT-0\nand\tO\nAmerican\tO\nTodd\tB-PER\nMartin\tI-PER\n,\tO\nthe\tO\nseventh\tT-1\nseeed\tT-1\n.\tO\n\nEighth\tT-1\nseed\tT-1\nMarc\tB-PER\nRosset\tI-PER\nof\tO\nSwitzerland\tO\nwas\tO\neliminated\tO\nin\tO\na\tO\none\tO\nhour\tO\n,\tO\n55\tO\nminute\tO\nbattle\tO\nby\tO\nunseeded\tT-0\nMark\tO\nPhilippoussis\tO\nof\tO\nAustralia\tO\n.\tO\n\nEighth\tO\nseed\tO\nMarc\tT-1\nRosset\tT-1\nof\tO\nSwitzerland\tB-LOC\nwas\tO\neliminated\tT-0\nin\tO\na\tO\none\tO\nhour\tO\n,\tO\n55\tO\nminute\tO\nbattle\tO\nby\tO\nunseeded\tO\nMark\tO\nPhilippoussis\tO\nof\tO\nAustralia\tO\n.\tO\n\nEighth\tO\nseed\tO\nMarc\tO\nRosset\tO\nof\tO\nSwitzerland\tO\nwas\tO\neliminated\tT-2\nin\tO\na\tO\none\tO\nhour\tO\n,\tO\n55\tO\nminute\tO\nbattle\tO\nby\tO\nunseeded\tT-0\nMark\tB-PER\nPhilippoussis\tI-PER\nof\tO\nAustralia\tT-1\n.\tO\n\nEighth\tO\nseed\tO\nMarc\tO\nRosset\tO\nof\tO\nSwitzerland\tO\nwas\tO\neliminated\tT-0\nin\tO\na\tO\none\tO\nhour\tO\n,\tO\n55\tO\nminute\tO\nbattle\tT-1\nby\tO\nunseeded\tO\nMark\tO\nPhilippoussis\tO\nof\tO\nAustralia\tB-LOC\n.\tO\n\nPhilippoussis\tB-PER\nsaved\tO\na\tO\nmatch\tO\npoint\tO\nat\tO\n5-6\tO\nin\tO\nthe\tO\nthird-set\tO\ntie\tO\nbreak\tO\nbefore\tT-1\nwinning\tT-0\n6-3\tO\n3-6\tO\n7-6\tO\n(\tO\n8-6\tO\n)\tO\n.\tO\n\nPhilippoussis\tB-PER\n's\tO\ncompatriot\tT-1\n,\tO\n13th\tO\nseed\tO\nJason\tO\nStoltenberg\tO\n,\tO\nwas\tT-0\nnot\tT-0\nas\tO\nfortunate\tO\n.\tO\n\nPhilippoussis\tO\n's\tO\ncompatriot\tO\n,\tO\n13th\tO\nseed\tO\nJason\tB-PER\nStoltenberg\tI-PER\n,\tO\nwas\tO\nnot\tO\nas\tO\nfortunate\tT-0\n.\tO\n\nHe\tO\nheld\tO\none\tO\nmatch\tO\npoint\tO\nat\tO\n9-8\tO\nin\tO\na\tO\nmarathon\tT-0\nthird-set\tO\ntie\tO\nbreak\tO\nbut\tO\nwas\tT-3\nbeaten\tT-3\n5-7\tO\n7-6\tO\n(\tO\n7-1\tO\n)\tO\n7-6\tO\n(\tO\n13-11\tO\n)\tO\nby\tO\nunseeded\tT-2\nDaniel\tB-PER\nVacek\tI-PER\nof\tO\nthe\tO\nCzech\tT-1\nRepublic\tT-1\n.\tO\n\nHe\tO\nheld\tO\none\tO\nmatch\tO\npoint\tO\nat\tO\n9-8\tO\nin\tO\na\tO\nmarathon\tO\nthird-set\tO\ntie\tO\nbreak\tO\nbut\tO\nwas\tO\nbeaten\tO\n5-7\tO\n7-6\tO\n(\tO\n7-1\tO\n)\tO\n7-6\tO\n(\tO\n13-11\tO\n)\tO\nby\tO\nunseeded\tO\nDaniel\tT-0\nVacek\tT-0\nof\tO\nthe\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n.\tO\n\n\"\tO\nI\tO\nknew\tO\nI\tO\nhad\tO\nto\tO\nserve\tO\nwell\tO\nand\tO\nkeep\tO\nthe\tO\npoints\tO\nshort\tO\nand\tO\nthat\tO\n's\tO\nwhat\tO\nI\tO\nwas\tO\nable\tO\nto\tO\ndo\tO\n,\tO\n\"\tO\nsaid\tT-0\nNestor\tB-PER\n,\tO\nwho\tO\nranks\tO\n10th\tO\nin\tO\ndoubles\tO\n.\tO\n\nThe\tO\nlanky\tT-1\nCanadian\tB-MISC\nbroke\tT-0\nMuster\tT-0\nat\tT-0\n4-3\tT-0\nin\tO\nthe\tO\nfirst\tO\nset\tO\nand\tO\n5-5\tO\nin\tO\nthe\tO\nsecond\tO\nbefore\tO\nending\tO\nthe\tO\nmatch\tO\non\tO\nhis\tO\nthird\tO\nmatch\tO\npoint\tO\nwhen\tO\nthe\tO\nAustrian\tT-2\nhit\tO\na\tO\nservice\tT-3\nreturn\tO\nlong\tO\n.\tO\n\nThe\tT-1\nlanky\tT-1\nCanadian\tT-1\nbroke\tT-0\nMuster\tB-PER\nat\tO\n4-3\tO\nin\tO\nthe\tO\nfirst\tO\nset\tO\nand\tO\n5-5\tO\nin\tO\nthe\tO\nsecond\tO\nbefore\tO\nending\tO\nthe\tO\nmatch\tO\non\tO\nhis\tT-2\nthird\tO\nmatch\tO\npoint\tO\nwhen\tO\nthe\tO\nAustrian\tT-3\nhit\tO\na\tO\nservice\tO\nreturn\tO\nlong\tO\n.\tO\n\nThe\tO\nlanky\tO\nCanadian\tO\nbroke\tO\nMuster\tO\nat\tO\n4-3\tO\nin\tO\nthe\tO\nfirst\tO\nset\tO\nand\tO\n5-5\tO\nin\tO\nthe\tO\nsecond\tO\nbefore\tO\nending\tO\nthe\tO\nmatch\tO\non\tO\nhis\tO\nthird\tO\nmatch\tO\npoint\tO\nwhen\tO\nthe\tO\nAustrian\tB-MISC\nhit\tT-0\na\tT-0\nservice\tT-0\nreturn\tT-0\nlong\tT-0\n.\tO\n\n\"\tO\nI\tO\nprobably\tO\ndid\tO\nn't\tO\nhit\tT-0\nfive\tO\nground\tO\nstrokes\tO\nin\tO\nthe\tO\nwhole\tO\nmatch\tO\n,\tO\n\"\tO\nsaid\tO\nMuster\tB-PER\n,\tO\nonly\tO\npartly\tO\njoking\tO\n.\tO\n\"\tO\n\nPlaying\tT-1\nat\tO\nnight\tO\nwas\tO\nnot\tO\nMuster\tB-PER\n's\tO\npreference\tT-0\n.\tO\n\"\tO\n\nIvanisevic\tB-PER\nrallied\tT-2\nfrom\tO\na\tO\n2-5\tO\ndeficit\tO\nin\tO\nthe\tO\nfirst\tO\nset\tO\nbut\tO\nthen\tO\nplayed\tO\nerratically\tO\nagainst\tO\nthe\tO\n44th-ranked\tO\nTillstrom\tT-0\n,\tO\nwho\tO\nwas\tO\na\tO\nsurprise\tO\nwinner\tO\nover\tO\nhis\tO\nfamous\tO\ncompatriot\tO\nStefan\tT-1\nEdberg\tT-1\nin\tO\nthe\tO\nsecond\tO\nround\tO\nat\tO\nWimbledon\tO\n.\tO\n\nIvanisevic\tT-1\nrallied\tO\nfrom\tO\na\tO\n2-5\tO\ndeficit\tO\nin\tO\nthe\tO\nfirst\tO\nset\tO\nbut\tO\nthen\tO\nplayed\tO\nerratically\tO\nagainst\tO\nthe\tO\n44th-ranked\tO\nTillstrom\tB-PER\n,\tO\nwho\tO\nwas\tO\na\tO\nsurprise\tO\nwinner\tT-0\nover\tO\nhis\tO\nfamous\tO\ncompatriot\tO\nStefan\tO\nEdberg\tO\nin\tO\nthe\tO\nsecond\tO\nround\tO\nat\tO\nWimbledon\tO\n.\tO\n\nIvanisevic\tO\nrallied\tT-0\nfrom\tO\na\tO\n2-5\tO\ndeficit\tO\nin\tO\nthe\tO\nfirst\tO\nset\tO\nbut\tO\nthen\tO\nplayed\tO\nerratically\tO\nagainst\tO\nthe\tO\n44th-ranked\tO\nTillstrom\tO\n,\tO\nwho\tO\nwas\tO\na\tO\nsurprise\tO\nwinner\tO\nover\tO\nhis\tO\nfamous\tO\ncompatriot\tT-1\nStefan\tB-PER\nEdberg\tI-PER\nin\tO\nthe\tO\nsecond\tO\nround\tO\nat\tO\nWimbledon\tT-2\n.\tO\n\nIvanisevic\tO\nrallied\tO\nfrom\tO\na\tO\n2-5\tO\ndeficit\tO\nin\tO\nthe\tO\nfirst\tO\nset\tO\nbut\tO\nthen\tO\nplayed\tT-1\nerratically\tT-1\nagainst\tO\nthe\tO\n44th-ranked\tO\nTillstrom\tO\n,\tO\nwho\tO\nwas\tO\na\tO\nsurprise\tO\nwinner\tO\nover\tO\nhis\tO\nfamous\tO\ncompatriot\tO\nStefan\tO\nEdberg\tO\nin\tT-0\nthe\tT-0\nsecond\tT-0\nround\tT-0\nat\tT-0\nWimbledon\tB-LOC\n.\tO\n\nIvanisevic\tB-PER\nhit\tT-2\n32\tO\naces\tT-3\nbut\tO\nwas\tO\noutplayed\tT-0\nfrom\tO\nthe\tO\nback\tO\ncourt\tO\nby\tO\nthe\tO\n24-year-old\tO\nTillstrom\tT-1\n.\tO\n\nIvanisevic\tO\nhit\tO\n32\tO\naces\tO\nbut\tO\nwas\tO\noutplayed\tT-2\nfrom\tO\nthe\tO\nback\tT-0\ncourt\tT-0\nby\tO\nthe\tO\n24-year-old\tT-1\nTillstrom\tB-PER\n.\tO\n\nThe\tO\nsixth-ranked\tT-0\nIvanisevic\tB-PER\n,\tO\nwho\tO\nlost\tO\nin\tO\nthe\tO\nfinal\tO\nat\tO\nIndianapolis\tO\nto\tO\nworld\tO\nnumber\tO\none\tO\nPete\tT-1\nSampras\tT-1\nof\tO\nthe\tO\nU.S.\tO\nlast\tO\nSunday\tO\n,\tO\nmade\tO\na\tO\nquick\tO\ngetaway\tO\nafter\tO\nhis\tO\nloss\tO\nbut\tO\ndid\tO\nsay\tO\n:\tO\n\"\tO\nSomething\tO\nwas\tO\nnot\tO\nthere\tO\nwhen\tO\nI\tO\narrived\tO\n(\tO\nin\tO\nToronto\tO\n)\tO\n.\tT-0\n\nThe\tO\nsixth-ranked\tO\nIvanisevic\tT-1\n,\tO\nwho\tO\nlost\tO\nin\tO\nthe\tO\nfinal\tT-0\nat\tT-0\nIndianapolis\tB-LOC\nto\tO\nworld\tT-2\nnumber\tT-2\none\tT-2\nPete\tO\nSampras\tO\nof\tO\nthe\tO\nU.S.\tO\nlast\tO\nSunday\tO\n,\tO\nmade\tO\na\tO\nquick\tO\ngetaway\tT-4\nafter\tO\nhis\tO\nloss\tT-3\nbut\tO\ndid\tO\nsay\tO\n:\tO\n\"\tO\nSomething\tO\nwas\tO\nnot\tO\nthere\tO\nwhen\tO\nI\tO\narrived\tO\n(\tO\nin\tO\nToronto\tO\n)\tO\n.\tO\n\nThe\tO\nsixth-ranked\tO\nIvanisevic\tO\n,\tO\nwho\tO\nlost\tT-0\nin\tO\nthe\tO\nfinal\tO\nat\tO\nIndianapolis\tT-2\nto\tO\nworld\tO\nnumber\tO\none\tO\nPete\tB-PER\nSampras\tI-PER\nof\tO\nthe\tO\nU.S.\tO\nlast\tO\nSunday\tO\n,\tO\nmade\tO\na\tO\nquick\tO\ngetaway\tT-3\nafter\tO\nhis\tO\nloss\tT-1\nbut\tO\ndid\tO\nsay\tO\n:\tO\n\"\tO\nSomething\tO\nwas\tO\nnot\tO\nthere\tO\nwhen\tO\nI\tO\narrived\tO\n(\tO\nin\tO\nToronto\tO\n)\tO\n.\tO\n\nThe\tO\nsixth-ranked\tO\nIvanisevic\tT-0\n,\tO\nwho\tO\nlost\tO\nin\tO\nthe\tO\nfinal\tO\nat\tO\nIndianapolis\tO\nto\tO\nworld\tO\nnumber\tO\none\tO\nPete\tT-1\nSampras\tT-1\nof\tO\nthe\tO\nU.S.\tB-LOC\nlast\tO\nSunday\tO\n,\tO\nmade\tO\na\tO\nquick\tO\ngetaway\tO\nafter\tO\nhis\tO\nloss\tO\nbut\tO\ndid\tO\nsay\tO\n:\tO\n\"\tO\nSomething\tO\nwas\tO\nnot\tO\nthere\tO\nwhen\tO\nI\tO\narrived\tT-2\n(\tO\nin\tO\nToronto\tO\n)\tO\n.\tO\n\nThe\tO\nsixth-ranked\tO\nIvanisevic\tO\n,\tO\nwho\tO\nlost\tT-0\nin\tO\nthe\tO\nfinal\tO\nat\tO\nIndianapolis\tO\nto\tO\nworld\tO\nnumber\tO\none\tO\nPete\tO\nSampras\tO\nof\tO\nthe\tO\nU.S.\tO\nlast\tO\nSunday\tO\n,\tO\nmade\tO\na\tO\nquick\tO\ngetaway\tT-1\nafter\tO\nhis\tO\nloss\tO\nbut\tO\ndid\tO\nsay\tO\n:\tO\n\"\tO\nSomething\tO\nwas\tO\nnot\tO\nthere\tO\nwhen\tO\nI\tO\narrived\tO\n(\tO\nin\tO\nToronto\tB-LOC\n)\tO\n.\tO\n\n\"\tO\nI\tO\nthought\tO\nhe\tO\nlooked\tO\na\tO\nlittle\tO\nunfocused\tT-0\nat\tO\ncertain\tO\ntimes\tO\non\tO\nhis\tO\nground\tO\nstrokes\tO\n,\tO\n\"\tO\nsaid\tT-1\nTillstrom\tB-PER\n.\tO\n\nThe\tO\n19-year-old\tT-0\nPhilippoussis\tB-PER\n,\tO\nwho\tT-1\nbeat\tO\nSampras\tO\nin\tO\nthe\tO\nthird\tO\nround\tO\nof\tO\nthis\tO\nyear\tO\n's\tO\nAustralian\tO\nOpen\tO\n,\tO\nstayed\tO\ncalm\tO\nin\tO\na\tO\nnervy\tO\nthird-set\tO\ntie\tO\nbreak\tO\nagainst\tO\nRosset\tO\n.\tO\n\nThe\tO\n19-year-old\tO\nPhilippoussis\tT-1\n,\tO\nwho\tT-2\nbeat\tO\nSampras\tB-PER\nin\tO\nthe\tO\nthird\tO\nround\tO\nof\tO\nthis\tO\nyear\tO\n's\tO\nAustralian\tT-0\nOpen\tO\n,\tO\nstayed\tO\ncalm\tO\nin\tO\na\tO\nnervy\tO\nthird-set\tO\ntie\tO\nbreak\tO\nagainst\tO\nRosset\tO\n.\tO\n\nThe\tO\n19-year-old\tO\nPhilippoussis\tO\n,\tO\nwho\tO\nbeat\tO\nSampras\tT-2\nin\tO\nthe\tO\nthird\tT-1\nround\tT-1\nof\tO\nthis\tO\nyear\tO\n's\tO\nAustralian\tB-MISC\nOpen\tI-MISC\n,\tO\nstayed\tT-0\ncalm\tO\nin\tO\na\tO\nnervy\tO\nthird-set\tO\ntie\tO\nbreak\tO\nagainst\tO\nRosset\tO\n.\tO\n\nThe\tO\n19-year-old\tO\nPhilippoussis\tT-0\n,\tO\nwho\tO\nbeat\tT-3\nSampras\tT-1\nin\tO\nthe\tO\nthird\tO\nround\tO\nof\tO\nthis\tO\nyear\tO\n's\tO\nAustralian\tT-2\nOpen\tT-2\n,\tO\nstayed\tO\ncalm\tO\nin\tO\na\tO\nnervy\tO\nthird-set\tO\ntie\tO\nbreak\tO\nagainst\tT-4\nRosset\tB-PER\n.\tO\n\nSoccer\tT-0\n-\tO\nResults\tO\nof\tO\nSouth\tB-MISC\nKorean\tI-MISC\npro-soccer\tT-1\ngames\tT-1\n.\tO\n\nResults\tT-0\nof\tO\nSouth\tB-MISC\nKorean\tI-MISC\npro-soccer\tT-1\ngames\tT-1\nplayed\tT-2\non\tO\nWednesday\tO\n.\tO\n\nAnyang\tB-ORG\n3\tT-0\nChonnam\tT-0\n3\tO\n(\tO\nhalftime\tO\n2-0\tO\n)\tO\n\nPuchon\tT-0\n0\tO\nSuwon\tB-ORG\n0\tO\n(\tO\nhalftime\tO\n0-0\tO\n)\tO\n\nPuchon\tB-ORG\n1\tT-0\n1\tT-0\n0\tT-0\n1\tT-0\n0\tT-0\n4\tT-0\n\nPohang\tB-ORG\n0\tT-0\n1\tT-0\n0\tT-0\n3\tT-0\n3\tT-0\n1\tT-0\n\nChonnam\tB-ORG\n0\tT-0\n1\tT-0\n1\tT-0\n5\tT-0\n6\tT-0\n1\tT-0\n\nSenegal\tB-LOC\ncholera\tO\noutbreak\tO\nkills\tT-0\nfive\tO\n.\tO\n\nAn\tO\noutbreak\tT-0\nof\tO\ncholera\tO\nhas\tO\nkilled\tT-2\nfive\tO\npeople\tO\nin\tO\nthe\tO\ncentral\tO\nSenegal\tB-LOC\ntown\tO\nof\tO\nKaolack\tO\n,\tO\nwhere\tO\nhealth\tO\nauthorities\tO\nhave\tO\nrecorded\tO\n291\tO\ncases\tO\nsince\tO\nAugust\tO\n11\tO\n,\tO\na\tO\nmedical\tO\nofficial\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nAn\tO\noutbreak\tO\nof\tO\ncholera\tT-1\nhas\tO\nkilled\tO\nfive\tO\npeople\tO\nin\tO\nthe\tO\ncentral\tO\nSenegal\tT-0\ntown\tT-0\nof\tO\nKaolack\tB-LOC\n,\tO\nwhere\tO\nhealth\tO\nauthorities\tO\nhave\tO\nrecorded\tO\n291\tO\ncases\tO\nsince\tO\nAugust\tO\n11\tO\n,\tO\na\tO\nmedical\tO\nofficial\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nPeople\tO\nare\tO\nrushing\tO\nto\tO\nthe\tO\nhospital\tO\nas\tO\nsoon\tO\nas\tO\nthe\tO\nfirst\tO\nsymptoms\tO\nappear\tT-0\n,\tO\nthat\tO\n's\tO\nwhy\tO\nwe\tO\nhave\tO\nfewer\tO\ndeaths\tO\n,\tO\n\"\tO\nhe\tO\ntold\tT-1\nReuters\tB-ORG\nby\tO\ntelephone\tO\nfrom\tO\nthe\tO\ntown\tO\n,\tO\n160\tO\nkm\tO\n(\tO\n100\tO\nmiles\tO\n)\tO\nsoutheast\tO\nof\tO\nthe\tO\nSenegalese\tT-2\ncapital\tO\nDakar\tO\n.\tO\n\nPeople\tO\nare\tO\nrushing\tT-2\nto\tO\nthe\tO\nhospital\tO\nas\tO\nsoon\tO\nas\tO\nthe\tO\nfirst\tO\nsymptoms\tO\nappear\tO\n,\tO\nthat\tO\n's\tO\nwhy\tO\nwe\tO\nhave\tO\nfewer\tT-3\ndeaths\tO\n,\tO\n\"\tO\nhe\tO\ntold\tO\nReuters\tO\nby\tO\ntelephone\tO\nfrom\tO\nthe\tO\ntown\tO\n,\tO\n160\tO\nkm\tO\n(\tO\n100\tO\nmiles\tO\n)\tO\nsoutheast\tT-0\nof\tT-0\nthe\tT-0\nSenegalese\tB-MISC\ncapital\tT-1\nDakar\tT-1\n.\tO\n\nPeople\tO\nare\tO\nrushing\tO\nto\tO\nthe\tO\nhospital\tO\nas\tO\nsoon\tO\nas\tO\nthe\tO\nfirst\tO\nsymptoms\tT-1\nappear\tO\n,\tO\nthat\tO\n's\tO\nwhy\tO\nwe\tO\nhave\tO\nfewer\tO\ndeaths\tO\n,\tO\n\"\tO\nhe\tO\ntold\tO\nReuters\tO\nby\tO\ntelephone\tO\nfrom\tO\nthe\tO\ntown\tO\n,\tO\n160\tO\nkm\tO\n(\tO\n100\tO\nmiles\tO\n)\tO\nsoutheast\tO\nof\tO\nthe\tO\nSenegalese\tT-0\ncapital\tT-0\nDakar\tB-LOC\n.\tO\n\nNigerian\tB-MISC\ngeneral\tT-2\ntakes\tT-1\nover\tT-0\nLiberia\tO\nECOMOG\tO\nforce\tO\n.\tO\n\nNigerian\tT-1\ngeneral\tO\ntakes\tT-0\nover\tT-0\nLiberia\tB-LOC\nECOMOG\tO\nforce\tO\n.\tO\n\nNigerian\tT-1\ngeneral\tT-0\ntakes\tT-3\nover\tT-3\nLiberia\tT-2\nECOMOG\tB-ORG\nforce\tO\n.\tO\n\nNigerian\tB-MISC\nMajor\tO\nGeneral\tO\nSam\tO\nVictor\tO\nMalu\tO\ntook\tO\nover\tT-1\non\tO\nThursday\tO\nas\tO\ncommander\tO\nof\tO\nthe\tO\nECOMOG\tT-2\npeacekeeping\tO\nforce\tO\nin\tO\nLiberia\tO\n,\tO\ntwo\tO\ndays\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nlatest\tO\nceasefire\tO\nin\tO\nthe\tO\nsix-year\tO\ncivil\tT-0\nwar\tT-0\n.\tO\n\nNigerian\tO\nMajor\tT-1\nGeneral\tT-3\nSam\tO\nVictor\tT-0\nMalu\tO\ntook\tT-5\nover\tO\non\tO\nThursday\tO\nas\tO\ncommander\tT-2\nof\tO\nthe\tO\nECOMOG\tB-ORG\npeacekeeping\tT-4\nforce\tO\nin\tO\nLiberia\tO\n,\tO\ntwo\tO\ndays\tO\nafter\tO\nthe\tO\nstart\tT-6\nof\tO\nthe\tO\nlatest\tO\nceasefire\tO\nin\tO\nthe\tO\nsix-year\tO\ncivil\tO\nwar\tO\n.\tO\n\nNigerian\tO\nMajor\tO\nGeneral\tO\nSam\tO\nVictor\tO\nMalu\tO\ntook\tO\nover\tO\non\tO\nThursday\tO\nas\tO\ncommander\tT-0\nof\tO\nthe\tO\nECOMOG\tO\npeacekeeping\tT-1\nforce\tO\nin\tO\nLiberia\tB-LOC\n,\tO\ntwo\tO\ndays\tO\nafter\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nlatest\tO\nceasefire\tT-2\nin\tO\nthe\tO\nsix-year\tO\ncivil\tT-3\nwar\tT-3\n.\tO\n\nMalu\tB-PER\nreplaced\tT-0\nanother\tO\nNigerian\tT-4\nmajor\tO\ngeneral\tO\n,\tO\nJohn\tT-5\nInienger\tT-5\n,\tO\nwho\tO\ntold\tT-1\nofficers\tO\nat\tO\nthe\tO\nhandover\tO\nceremony\tO\nthat\tO\npeace\tO\nwas\tO\nnow\tO\nat\tO\nhand\tO\nfor\tO\nLiberia\tT-3\nafter\tO\nsix\tO\nyears\tO\nof\tO\nfighting\tO\nand\tO\nmore\tO\nthan\tO\na\tO\ndozen\tO\nfailed\tT-2\naccords\tO\n.\tO\n\nMalu\tT-2\nreplaced\tO\nanother\tO\nNigerian\tB-MISC\nmajor\tT-4\ngeneral\tT-4\n,\tO\nJohn\tT-3\nInienger\tT-3\n,\tO\nwho\tO\ntold\tO\nofficers\tO\nat\tO\nthe\tO\nhandover\tO\nceremony\tT-0\nthat\tO\npeace\tO\nwas\tO\nnow\tO\nat\tO\nhand\tO\nfor\tO\nLiberia\tO\nafter\tO\nsix\tO\nyears\tO\nof\tO\nfighting\tO\nand\tO\nmore\tO\nthan\tO\na\tO\ndozen\tT-1\nfailed\tO\naccords\tO\n.\tO\n\nMalu\tO\nreplaced\tO\nanother\tO\nNigerian\tT-0\nmajor\tT-0\ngeneral\tT-0\n,\tO\nJohn\tB-PER\nInienger\tI-PER\n,\tO\nwho\tO\ntold\tO\nofficers\tO\nat\tO\nthe\tO\nhandover\tO\nceremony\tO\nthat\tO\npeace\tT-1\nwas\tO\nnow\tO\nat\tO\nhand\tO\nfor\tO\nLiberia\tO\nafter\tO\nsix\tO\nyears\tO\nof\tO\nfighting\tO\nand\tO\nmore\tO\nthan\tO\na\tO\ndozen\tO\nfailed\tO\naccords\tO\n.\tO\n\nMalu\tO\nreplaced\tO\nanother\tO\nNigerian\tO\nmajor\tO\ngeneral\tO\n,\tO\nJohn\tO\nInienger\tO\n,\tO\nwho\tO\ntold\tO\nofficers\tO\nat\tO\nthe\tO\nhandover\tO\nceremony\tT-1\nthat\tO\npeace\tO\nwas\tO\nnow\tO\nat\tO\nhand\tO\nfor\tO\nLiberia\tB-LOC\nafter\tO\nsix\tO\nyears\tO\nof\tO\nfighting\tT-0\nand\tO\nmore\tO\nthan\tO\na\tO\ndozen\tO\nfailed\tO\naccords\tO\n.\tO\n\n\"\tO\nThe\tO\nsearch\tO\nfor\tO\npeace\tT-0\nin\tO\nLiberia\tB-LOC\nhas\tO\nbeen\tO\ndifficult\tO\n,\tO\nchallenging\tO\nand\tO\nsometimes\tO\npainful\tO\n.\tO\n\nUnited\tB-ORG\nNations\tI-ORG\nmilitary\tT-0\nobservers\tO\ntravelling\tO\nto\tO\nthe\tO\nwestern\tO\ntown\tO\nof\tO\nTubmanburg\tT-1\non\tO\nWednesday\tO\nto\tO\nmonitor\tT-4\nthe\tT-4\nceasefire\tT-4\nwere\tO\ndelayed\tO\nby\tO\nshooting\tO\nalong\tO\nthe\tO\nhighway\tO\n,\tO\nU.N.\tT-2\nspecial\tT-2\nrepresentative\tT-2\nAnthony\tT-3\nNyakyi\tT-3\nsaid\tO\n.\tO\n\nUnited\tO\nNations\tO\nmilitary\tT-2\nobservers\tT-2\ntravelling\tO\nto\tO\nthe\tO\nwestern\tT-1\ntown\tT-1\nof\tT-0\nTubmanburg\tB-LOC\non\tO\nWednesday\tO\nto\tO\nmonitor\tO\nthe\tO\nceasefire\tO\nwere\tO\ndelayed\tO\nby\tO\nshooting\tO\nalong\tO\nthe\tO\nhighway\tO\n,\tO\nU.N.\tO\nspecial\tO\nrepresentative\tO\nAnthony\tO\nNyakyi\tO\nsaid\tO\n.\tO\n\nUnited\tO\nNations\tO\nmilitary\tO\nobservers\tT-0\ntravelling\tO\nto\tO\nthe\tO\nwestern\tO\ntown\tO\nof\tO\nTubmanburg\tT-2\non\tO\nWednesday\tO\nto\tO\nmonitor\tO\nthe\tO\nceasefire\tO\nwere\tO\ndelayed\tO\nby\tO\nshooting\tO\nalong\tO\nthe\tO\nhighway\tO\n,\tO\nU.N.\tB-ORG\nspecial\tO\nrepresentative\tT-1\nAnthony\tT-3\nNyakyi\tT-3\nsaid\tO\n.\tO\n\nUnited\tT-1\nNations\tT-1\nmilitary\tO\nobservers\tO\ntravelling\tT-0\nto\tO\nthe\tO\nwestern\tO\ntown\tO\nof\tO\nTubmanburg\tT-2\non\tO\nWednesday\tO\nto\tO\nmonitor\tO\nthe\tO\nceasefire\tO\nwere\tO\ndelayed\tO\nby\tO\nshooting\tO\nalong\tO\nthe\tO\nhighway\tO\n,\tO\nU.N.\tO\nspecial\tO\nrepresentative\tO\nAnthony\tB-PER\nNyakyi\tI-PER\nsaid\tO\n.\tO\n\nThey\tO\nfinally\tO\nwent\tT-0\nahead\tO\nwith\tO\nan\tO\nescort\tO\nfrom\tO\nthe\tO\nULIMO-J\tB-ORG\nfaction\tT-1\n.\tO\n\nFaction\tT-2\nleaders\tO\nwho\tO\nagreed\tO\na\tO\nnew\tO\npeace\tT-0\ndeal\tO\nin\tT-1\nthe\tT-1\nNigerian\tB-MISC\ncapital\tO\nAbuja\tO\non\tO\nSaturday\tO\nhave\tO\naccused\tO\neach\tO\nother\tO\nof\tO\nbreaking\tO\nthe\tO\nceasefire\tO\n.\tT-2\n\nFaction\tO\nleaders\tO\nwho\tO\nagreed\tO\na\tO\nnew\tO\npeace\tO\ndeal\tO\nin\tT-0\nthe\tO\nNigerian\tO\ncapital\tT-1\nAbuja\tB-LOC\non\tO\nSaturday\tO\nhave\tO\naccused\tT-2\neach\tO\nother\tO\nof\tO\nbreaking\tO\nthe\tO\nceasefire\tO\n.\tO\n\nThe\tT-0\nECOMOG\tB-ORG\nforce\tT-1\n,\tO\ncurrently\tT-2\n10,000\tO\nstrong\tO\n,\tO\nwas\tO\nsent\tO\nto\tO\nLiberia\tO\nby\tO\nthe\tO\nEconomic\tO\nCommunity\tO\nof\tO\nWest\tO\nAfrican\tO\nStates\tO\nin\tO\n1990\tO\nat\tO\nthe\tO\nheight\tO\nof\tO\nthe\tO\nfighting\tO\n.\tO\n\nThe\tO\nECOMOG\tO\nforce\tO\n,\tO\ncurrently\tO\n10,000\tO\nstrong\tO\n,\tO\nwas\tO\nsent\tO\nto\tT-1\nLiberia\tB-LOC\nby\tO\nthe\tO\nEconomic\tO\nCommunity\tO\nof\tO\nWest\tT-0\nAfrican\tT-0\nStates\tT-0\nin\tO\n1990\tO\nat\tO\nthe\tO\nheight\tO\nof\tO\nthe\tO\nfighting\tO\n.\tO\n\nThe\tO\nECOMOG\tT-0\nforce\tO\n,\tO\ncurrently\tO\n10,000\tO\nstrong\tO\n,\tO\nwas\tO\nsent\tT-2\nto\tT-2\nLiberia\tT-1\nby\tT-3\nthe\tT-3\nEconomic\tB-ORG\nCommunity\tI-ORG\nof\tI-ORG\nWest\tI-ORG\nAfrican\tI-ORG\nStates\tI-ORG\nin\tO\n1990\tO\nat\tO\nthe\tO\nheight\tO\nof\tO\nthe\tO\nfighting\tO\n.\tO\n\nGuinea\tB-LOC\ncalls\tT-2\ntwo\tT-0\ndays\tT-0\nof\tO\nprayer\tT-1\n.\tO\n\nThe\tO\nWest\tB-MISC\nAfrican\tI-MISC\nstate\tT-0\nof\tT-0\nGuinea\tT-0\ndeclared\tO\nThursday\tO\nand\tO\nFriday\tO\ndays\tO\nof\tO\nnational\tO\nprayer\tO\n.\tO\n\nThe\tO\nWest\tT-1\nAfrican\tT-1\nstate\tT-0\nof\tT-0\nGuinea\tB-LOC\ndeclared\tO\nThursday\tO\nand\tO\nFriday\tO\ndays\tO\nof\tO\nnational\tO\nprayer\tO\n.\tO\n\nA\tT-2\ngovernment\tT-2\nstatement\tT-2\n,\tO\nbroadcast\tT-5\nrepeatedly\tO\nby\tO\nstate\tO\nradio\tO\n,\tO\nsaid\tT-6\nthe\tO\ntwo\tO\ndays\tO\nof\tO\nprayer\tO\nwere\tO\n\"\tO\nfor\tO\nthe\tO\ndead\tO\n,\tO\nfor\tO\npeace\tT-0\nand\tT-0\nprosperity\tT-0\nin\tT-0\nGuinea\tB-LOC\n,\tO\nthe\tT-3\nvictory\tT-3\nof\tO\nthe\tO\nnew\tO\ngovernment\tT-1\nand\tO\nthe\tO\nhealth\tT-4\nof\tT-4\nthe\tT-4\nhead\tT-4\nof\tT-4\nstate\tT-4\n\"\tO\n.\tO\n\nGuinea\tB-LOC\n's\tO\npresident\tT-2\n,\tO\nLansana\tT-0\nConte\tT-0\n,\tO\nvice-president\tO\nof\tO\nthe\tO\nOrganisation\tT-1\nof\tT-1\nthe\tT-1\nIslamic\tT-1\nConference\tT-1\n,\tO\nleft\tO\nfor\tO\nKuwait\tO\non\tO\nAugust\tO\n16\tO\nto\tO\nprepare\tO\nthe\tO\nnext\tO\nOIC\tT-3\nsummit\tT-3\nin\tO\nPakistan\tO\nin\tO\n1997\tO\n.\tO\n\nGuinea\tO\n's\tO\npresident\tO\n,\tO\nLansana\tO\nConte\tO\n,\tO\nvice-president\tO\nof\tT-4\nthe\tT-4\nOrganisation\tB-ORG\nof\tI-ORG\nthe\tI-ORG\nIslamic\tI-ORG\nConference\tI-ORG\n,\tO\nleft\tT-0\nfor\tO\nKuwait\tT-3\non\tO\nAugust\tO\n16\tO\nto\tO\nprepare\tT-1\nthe\tO\nnext\tO\nOIC\tT-2\nsummit\tT-2\nin\tO\nPakistan\tO\nin\tO\n1997\tO\n.\tO\n\nGuinea\tO\n's\tO\npresident\tO\n,\tO\nLansana\tO\nConte\tO\n,\tO\nvice-president\tO\nof\tO\nthe\tO\nOrganisation\tO\nof\tO\nthe\tO\nIslamic\tO\nConference\tO\n,\tO\nleft\tT-0\nfor\tO\nKuwait\tB-LOC\non\tO\nAugust\tO\n16\tO\nto\tO\nprepare\tO\nthe\tO\nnext\tO\nOIC\tO\nsummit\tT-1\nin\tO\nPakistan\tO\nin\tO\n1997\tO\n.\tO\n\nGuinea\tO\n's\tO\npresident\tO\n,\tO\nLansana\tO\nConte\tO\n,\tO\nvice-president\tT-2\nof\tO\nthe\tO\nOrganisation\tO\nof\tO\nthe\tO\nIslamic\tO\nConference\tO\n,\tO\nleft\tT-0\nfor\tT-0\nKuwait\tT-0\non\tT-0\nAugust\tT-0\n16\tT-0\nto\tT-0\nprepare\tT-0\nthe\tT-0\nnext\tT-0\nOIC\tB-ORG\nsummit\tT-1\nin\tT-1\nPakistan\tT-1\nin\tT-1\n1997\tT-1\n.\tO\n\nGuinea\tO\n's\tO\npresident\tO\n,\tO\nLansana\tO\nConte\tO\n,\tO\nvice-president\tO\nof\tO\nthe\tO\nOrganisation\tO\nof\tO\nthe\tO\nIslamic\tO\nConference\tO\n,\tO\nleft\tT-3\nfor\tO\nKuwait\tO\non\tO\nAugust\tO\n16\tO\nto\tO\nprepare\tT-0\nthe\tO\nnext\tO\nOIC\tT-1\nsummit\tT-1\nin\tT-1\nPakistan\tB-LOC\nin\tT-2\n1997\tT-2\n.\tO\n\nKoranic\tB-MISC\nreading\tT-0\nsessions\tT-3\nand\tO\nprayers\tO\nwere\tO\nto\tO\nbe\tO\nheld\tO\nin\tO\nthe\tO\nfarming\tO\ntown\tO\nof\tO\nBadi-Tondon\tT-1\n,\tO\nnear\tO\nhis\tO\nhome\tO\nabout\tO\n60\tO\nkm\tO\n(\tO\n40\tO\nmiles\tO\n)\tO\nfrom\tO\nthe\tO\ncapital\tO\nConakry\tT-2\n.\tO\n\nKoranic\tT-2\nreading\tO\nsessions\tO\nand\tO\nprayers\tO\nwere\tO\nto\tO\nbe\tO\nheld\tO\nin\tO\nthe\tO\nfarming\tT-0\ntown\tT-1\nof\tO\nBadi-Tondon\tB-LOC\n,\tO\nnear\tO\nhis\tO\nhome\tO\nabout\tO\n60\tO\nkm\tO\n(\tO\n40\tO\nmiles\tO\n)\tO\nfrom\tO\nthe\tO\ncapital\tO\nConakry\tO\n.\tO\n\nKoranic\tO\nreading\tO\nsessions\tO\nand\tO\nprayers\tO\nwere\tO\nto\tO\nbe\tO\nheld\tO\nin\tO\nthe\tO\nfarming\tO\ntown\tO\nof\tO\nBadi-Tondon\tT-0\n,\tO\nnear\tO\nhis\tO\nhome\tO\nabout\tO\n60\tT-1\nkm\tT-1\n(\tO\n40\tO\nmiles\tO\n)\tO\nfrom\tO\nthe\tO\ncapital\tT-2\nConakry\tB-LOC\n.\tO\n\nConte\tB-PER\n,\tO\nan\tO\narmy\tT-2\ngeneral\tT-3\n,\tO\nsurvived\tO\na\tO\nFebruary\tO\narmy\tO\npay\tO\nrevolt\tO\nwhich\tO\nat\tO\nthe\tO\ntime\tO\nhe\tT-0\ndescribed\tO\nas\tO\na\tO\nveiled\tO\nattempt\tO\nto\tO\ntopple\tO\nhim\tT-1\n.\tO\n\nConte\tB-PER\nseized\tO\npower\tT-0\nin\tO\n1984\tO\nafter\tO\nthe\tO\ndeath\tT-1\nof\tO\nveteran\tO\nMarxist\tO\nleader\tO\nAhmed\tO\nSekou\tO\nToure\tO\n.\tO\n\nConte\tO\nseized\tT-0\npower\tT-0\nin\tO\n1984\tO\nafter\tO\nthe\tO\ndeath\tT-1\nof\tO\nveteran\tO\nMarxist\tB-MISC\nleader\tT-2\nAhmed\tO\nSekou\tO\nToure\tO\n.\tO\n\nConte\tT-2\nseized\tT-1\npower\tO\nin\tO\n1984\tO\nafter\tO\nthe\tO\ndeath\tO\nof\tO\nveteran\tO\nMarxist\tT-0\nleader\tT-0\nAhmed\tB-PER\nSekou\tI-PER\nToure\tI-PER\n.\tO\n\nSouth\tB-MISC\nAfrican\tI-MISC\nanswers\tT-0\nU.S.\tO\nmessage\tO\nin\tO\na\tO\nbottle\tO\n.\tO\n\nSouth\tO\nAfrican\tO\nanswers\tT-1\nU.S.\tB-LOC\nmessage\tO\nin\tO\na\tO\nbottle\tT-0\n.\tO\n\nA\tT-0\nSouth\tB-MISC\nAfrican\tI-MISC\nboy\tT-1\nis\tO\nwriting\tT-2\nback\tO\nto\tO\nan\tO\nAmerican\tO\ngirl\tO\nwhose\tO\nmessage\tO\nin\tO\na\tO\nbottle\tO\nhe\tO\nfound\tO\nwashed\tO\nup\tO\non\tO\nPresident\tO\nNelson\tO\nMandela\tO\n's\tO\nold\tO\nprison\tO\nisland\tO\n.\tO\n\nA\tO\nSouth\tT-0\nAfrican\tT-0\nboy\tT-0\nis\tO\nwriting\tO\nback\tO\nto\tO\nan\tO\nAmerican\tB-MISC\ngirl\tT-1\nwhose\tO\nmessage\tO\nin\tO\na\tO\nbottle\tO\nhe\tO\nfound\tO\nwashed\tT-2\nup\tO\non\tO\nPresident\tO\nNelson\tO\nMandela\tO\n's\tO\nold\tO\nprison\tT-3\nisland\tO\n.\tO\n\nA\tO\nSouth\tO\nAfrican\tO\nboy\tO\nis\tO\nwriting\tO\nback\tO\nto\tO\nan\tO\nAmerican\tO\ngirl\tO\nwhose\tO\nmessage\tO\nin\tO\na\tO\nbottle\tO\nhe\tO\nfound\tO\nwashed\tO\nup\tO\non\tO\nPresident\tO\nNelson\tB-PER\nMandela\tI-PER\n's\tO\nold\tO\nprison\tT-0\nisland\tT-1\n.\tO\n\nBut\tO\nCarlo\tB-PER\nHoffmann\tI-PER\n,\tO\nan\tO\n11-year-old\tT-0\njailer\tT-0\n's\tT-0\nson\tT-0\nwho\tT-4\nfound\tT-1\nthe\tO\nbottle\tO\non\tO\nthe\tO\nbeach\tO\nat\tO\nRobben\tO\nIsland\tO\noff\tO\nCape\tO\nTown\tO\nafter\tO\nwinter\tO\nstorms\tT-2\n,\tO\nwill\tO\nsend\tO\nhis\tO\nletter\tO\nback\tO\nby\tO\nordinary\tO\nmail\tO\non\tO\nThursday\tO\n,\tO\nthe\tO\npost\tO\noffice\tO\nsaid\tT-3\n.\tO\n\nBut\tO\nCarlo\tO\nHoffmann\tO\n,\tO\nan\tO\n11-year-old\tO\njailer\tO\n's\tO\nson\tO\nwho\tO\nfound\tT-1\nthe\tO\nbottle\tO\non\tO\nthe\tO\nbeach\tO\nat\tO\nRobben\tB-LOC\nIsland\tI-LOC\noff\tO\nCape\tT-0\nTown\tO\nafter\tO\nwinter\tO\nstorms\tO\n,\tO\nwill\tO\nsend\tT-2\nhis\tO\nletter\tO\nback\tO\nby\tO\nordinary\tO\nmail\tO\non\tO\nThursday\tO\n,\tO\nthe\tO\npost\tO\noffice\tO\nsaid\tO\n.\tO\n\nBut\tO\nCarlo\tT-0\nHoffmann\tT-0\n,\tO\nan\tO\n11-year-old\tO\njailer\tT-1\n's\tT-1\nson\tT-1\nwho\tO\nfound\tO\nthe\tO\nbottle\tO\non\tO\nthe\tO\nbeach\tO\nat\tO\nRobben\tO\nIsland\tO\noff\tO\nCape\tB-LOC\nTown\tI-LOC\nafter\tO\nwinter\tT-2\nstorms\tO\n,\tO\nwill\tO\nsend\tO\nhis\tO\nletter\tO\nback\tO\nby\tO\nordinary\tO\nmail\tO\non\tO\nThursday\tO\n,\tO\nthe\tO\npost\tO\noffice\tO\nsaid\tO\n.\tO\n\nDanielle\tB-PER\nMurray\tI-PER\nfrom\tT-0\nSandusky\tO\n,\tO\nOhio\tO\n,\tO\nthe\tO\nsame\tT-1\nage\tT-1\nas\tT-1\nher\tO\nnew\tO\npenfriend\tO\n,\tO\nasked\tO\nfor\tO\na\tO\nreply\tO\nfrom\tO\nwhoever\tO\nreceived\tO\nthe\tO\nmessage\tO\nshe\tO\nflung\tO\non\tO\nits\tO\njourney\tO\nmonths\tO\nago\tO\non\tO\nthe\tO\nother\tO\nside\tO\nof\tO\nthe\tO\nAtlantic\tO\nOcean\tO\n.\tO\n\nDanielle\tT-1\nMurray\tT-1\nfrom\tO\nSandusky\tB-LOC\n,\tO\nOhio\tT-0\n,\tO\nthe\tO\nsame\tO\nage\tO\nas\tO\nher\tO\nnew\tO\npenfriend\tO\n,\tO\nasked\tO\nfor\tO\na\tO\nreply\tO\nfrom\tO\nwhoever\tO\nreceived\tO\nthe\tO\nmessage\tO\nshe\tO\nflung\tO\non\tO\nits\tO\njourney\tO\nmonths\tO\nago\tO\non\tO\nthe\tO\nother\tO\nside\tO\nof\tO\nthe\tO\nAtlantic\tO\nOcean\tO\n.\tO\n\nDanielle\tO\nMurray\tO\nfrom\tT-2\nSandusky\tT-0\n,\tO\nOhio\tB-LOC\n,\tO\nthe\tO\nsame\tO\nage\tO\nas\tO\nher\tO\nnew\tO\npenfriend\tO\n,\tO\nasked\tO\nfor\tO\na\tO\nreply\tO\nfrom\tO\nwhoever\tO\nreceived\tO\nthe\tO\nmessage\tO\nshe\tO\nflung\tO\non\tO\nits\tO\njourney\tO\nmonths\tO\nago\tO\non\tO\nthe\tO\nother\tT-1\nside\tT-1\nof\tO\nthe\tO\nAtlantic\tO\nOcean\tO\n.\tO\n\nDanielle\tO\nMurray\tO\nfrom\tO\nSandusky\tO\n,\tO\nOhio\tT-0\n,\tO\nthe\tO\nsame\tO\nage\tO\nas\tO\nher\tO\nnew\tO\npenfriend\tO\n,\tO\nasked\tT-2\nfor\tO\na\tO\nreply\tO\nfrom\tO\nwhoever\tO\nreceived\tT-3\nthe\tO\nmessage\tO\nshe\tO\nflung\tT-1\non\tO\nits\tO\njourney\tO\nmonths\tO\nago\tO\non\tO\nthe\tO\nother\tO\nside\tO\nof\tO\nthe\tO\nAtlantic\tB-LOC\nOcean\tI-LOC\n.\tO\n\nRottweiler\tB-MISC\nkills\tT-0\nSouth\tT-2\nAfrican\tT-2\ntoddler\tT-2\n.\tO\n\nRottweiler\tT-1\nkills\tT-1\nSouth\tB-MISC\nAfrican\tI-MISC\ntoddler\tT-2\n.\tO\n\nA\tO\nrottweiler\tO\ndog\tO\nbelonging\tO\nto\tO\nan\tO\nelderly\tT-0\nSouth\tB-MISC\nAfrican\tI-MISC\ncouple\tT-1\nsavaged\tO\nto\tO\ndeath\tO\ntheir\tO\ntwo-year-old\tO\ngrandson\tO\nwho\tO\nwas\tO\nvisiting\tT-2\n,\tO\npolice\tO\nsaid\tT-3\non\tO\nThursday\tO\n.\tO\n\nThe\tT-0\ndog\tT-0\nattacked\tO\nLouis\tB-PER\nBooy\tI-PER\nin\tO\nthe\tO\nfront\tO\ngarden\tO\nof\tO\nhis\tO\ngrandparents\tO\n'\tO\nhouse\tO\nin\tO\nVanderbijlpark\tO\nnear\tO\nJohannesburg\tO\non\tO\nTuesday\tO\n.\tO\n\nThe\tO\ndog\tO\nattacked\tO\nLouis\tT-2\nBooy\tT-2\nin\tO\nthe\tO\nfront\tO\ngarden\tT-1\nof\tO\nhis\tO\ngrandparents\tO\n'\tO\nhouse\tO\nin\tO\nVanderbijlpark\tB-LOC\nnear\tT-0\nJohannesburg\tT-3\non\tO\nTuesday\tO\n.\tO\n\nThe\tO\ndog\tO\nattacked\tO\nLouis\tO\nBooy\tO\nin\tO\nthe\tO\nfront\tO\ngarden\tT-0\nof\tO\nhis\tO\ngrandparents\tO\n'\tO\nhouse\tT-1\nin\tO\nVanderbijlpark\tO\nnear\tO\nJohannesburg\tB-LOC\non\tO\nTuesday\tO\n.\tO\n\nDogs\tO\nfierce\tO\nenough\tO\nto\tO\nscare\tO\noff\tO\nburglars\tO\nare\tO\nbecoming\tO\nincreasingly\tO\npopular\tO\nin\tO\nthe\tO\ncrime-infested\tO\nJohannesburg\tB-LOC\narea\tT-0\n.\tO\n\nINDICATORS\tT-0\n-\tO\nHungary\tB-LOC\n-\tO\nupdated\tT-1\nAug\tO\n22\tO\n.\tO\n\nNBH\tB-ORG\ntrade\tT-1\nbalance\tT-1\nJan-May\tO\n-\tO\n$\tO\n934\tO\nmillion\tO\n(\tO\nJan-April\tO\n-\tO\n$\tO\n774\tO\nmillion\tO\n)\tO\n\nThe\tO\nNBH\tB-ORG\nis\tO\nBBB-minus\tO\nby\tO\nDuff\tO\n&\tO\nPhelps\tO\n,\tO\nIBCA\tO\nand\tO\nThomson\tO\nBankWatch\tO\n,\tO\nBB-plus\tT-0\nby\tO\nS&P\tO\n,\tO\nBA1\tT-1\nby\tO\nMoody\tO\n's\tO\nInvestors\tO\nService\tO\n,\tO\nBBB+\tO\nby\tO\nthe\tO\nJapan\tO\nCredit\tO\nRating\tO\nAgency\tO\n.\tO\n\nThe\tO\nNBH\tT-0\nis\tO\nBBB-minus\tO\nby\tO\nDuff\tB-ORG\n&\tI-ORG\nPhelps\tI-ORG\n,\tO\nIBCA\tO\nand\tO\nThomson\tO\nBankWatch\tO\n,\tO\nBB-plus\tO\nby\tO\nS&P\tO\n,\tO\nBA1\tO\nby\tO\nMoody\tO\n's\tO\nInvestors\tO\nService\tO\n,\tO\nBBB+\tO\nby\tO\nthe\tO\nJapan\tT-1\nCredit\tT-1\nRating\tT-1\nAgency\tT-1\n.\tO\n\nThe\tO\nNBH\tO\nis\tO\nBBB-minus\tO\nby\tO\nDuff\tT-0\n&\tT-0\nPhelps\tT-0\n,\tO\nIBCA\tB-ORG\nand\tO\nThomson\tT-1\nBankWatch\tO\n,\tO\nBB-plus\tO\nby\tO\nS&P\tO\n,\tO\nBA1\tO\nby\tO\nMoody\tO\n's\tO\nInvestors\tO\nService\tO\n,\tO\nBBB+\tO\nby\tO\nthe\tO\nJapan\tO\nCredit\tO\nRating\tO\nAgency\tO\n.\tO\n\nThe\tO\nNBH\tO\nis\tO\nBBB-minus\tO\nby\tO\nDuff\tT-0\n&\tT-0\nPhelps\tT-0\n,\tO\nIBCA\tT-1\nand\tO\nThomson\tB-ORG\nBankWatch\tI-ORG\n,\tO\nBB-plus\tO\nby\tO\nS&P\tO\n,\tO\nBA1\tO\nby\tO\nMoody\tO\n's\tO\nInvestors\tO\nService\tO\n,\tO\nBBB+\tO\nby\tO\nthe\tO\nJapan\tT-2\nCredit\tO\nRating\tO\nAgency\tO\n.\tO\n\nThe\tO\nNBH\tO\nis\tO\nBBB-minus\tT-0\nby\tT-3\nDuff\tO\n&\tO\nPhelps\tO\n,\tO\nIBCA\tT-1\nand\tT-1\nThomson\tT-1\nBankWatch\tT-1\n,\tO\nBB-plus\tO\nby\tT-4\nS&P\tB-ORG\n,\tO\nBA1\tO\nby\tT-5\nMoody\tO\n's\tO\nInvestors\tT-2\nService\tT-2\n,\tO\nBBB+\tO\nby\tT-6\nthe\tO\nJapan\tO\nCredit\tO\nRating\tO\nAgency\tO\n.\tO\n\nThe\tO\nNBH\tT-2\nis\tO\nBBB-minus\tO\nby\tO\nDuff\tO\n&\tO\nPhelps\tO\n,\tO\nIBCA\tO\nand\tO\nThomson\tT-1\nBankWatch\tT-1\n,\tO\nBB-plus\tO\nby\tO\nS&P\tO\n,\tO\nBA1\tO\nby\tT-0\nMoody\tB-ORG\n's\tI-ORG\nInvestors\tI-ORG\nService\tI-ORG\n,\tO\nBBB+\tO\nby\tO\nthe\tO\nJapan\tO\nCredit\tO\nRating\tO\nAgency\tO\n.\tO\n\nThe\tO\nNBH\tT-0\nis\tO\nBBB-minus\tO\nby\tO\nDuff\tO\n&\tO\nPhelps\tO\n,\tO\nIBCA\tO\nand\tO\nThomson\tO\nBankWatch\tO\n,\tO\nBB-plus\tO\nby\tO\nS&P\tO\n,\tO\nBA1\tO\nby\tO\nMoody\tT-1\n's\tT-1\nInvestors\tT-1\nService\tT-1\n,\tO\nBBB+\tO\nby\tO\nthe\tO\nJapan\tB-ORG\nCredit\tI-ORG\nRating\tI-ORG\nAgency\tI-ORG\n.\tO\n\nThe\tO\nNBH\tB-ORG\ntrade\tT-1\ndata\tT-1\nis\tO\nbased\tT-0\non\tO\ncash\tT-2\nflow\tO\n,\tO\nMIT\tO\ndata\tO\non\tO\ncustoms\tO\nstatistics\tO\n.\tO\n\nThe\tO\nNBH\tO\ntrade\tO\ndata\tO\nis\tO\nbased\tO\non\tO\ncash\tT-0\nflow\tT-2\n,\tO\nMIT\tB-ORG\ndata\tO\non\tO\ncustoms\tO\nstatistics\tT-1\n.\tO\n\nFifty\tO\nRussians\tB-MISC\ndie\tT-0\nin\tO\nclash\tT-1\nwith\tO\nrebels-Interfax\tO\n.\tO\n\nAt\tO\nleast\tO\n50\tO\nRussian\tB-MISC\nservicemen\tT-0\nhave\tO\nbeen\tO\nkilled\tT-2\nin\tO\na\tO\nbattle\tO\nwith\tO\nseparatist\tO\nrebels\tO\nwhich\tO\nerupted\tT-1\nin\tO\nthe\tO\nChechen\tO\ncapital\tO\nGrozny\tO\non\tO\nThursday\tO\nand\tO\ncontinued\tO\nafter\tO\nRussia\tO\nand\tO\nthe\tO\nrebels\tO\nagreed\tO\na\tO\ntruce\tO\n,\tO\nInterfax\tO\nnews\tO\nagency\tO\nsaid\tO\n.\tO\n\nAt\tO\nleast\tO\n50\tO\nRussian\tO\nservicemen\tO\nhave\tO\nbeen\tO\nkilled\tT-0\nin\tO\na\tO\nbattle\tO\nwith\tO\nseparatist\tO\nrebels\tO\nwhich\tO\nerupted\tT-1\nin\tO\nthe\tO\nChechen\tB-MISC\ncapital\tO\nGrozny\tO\non\tO\nThursday\tO\nand\tO\ncontinued\tO\nafter\tO\nRussia\tO\nand\tO\nthe\tO\nrebels\tO\nagreed\tT-2\na\tO\ntruce\tO\n,\tO\nInterfax\tO\nnews\tO\nagency\tO\nsaid\tT-3\n.\tO\n\nAt\tO\nleast\tO\n50\tO\nRussian\tO\nservicemen\tO\nhave\tO\nbeen\tO\nkilled\tT-3\nin\tO\na\tO\nbattle\tO\nwith\tO\nseparatist\tO\nrebels\tO\nwhich\tO\nerupted\tO\nin\tO\nthe\tO\nChechen\tT-1\ncapital\tT-0\nGrozny\tB-LOC\non\tO\nThursday\tO\nand\tO\ncontinued\tO\nafter\tO\nRussia\tO\nand\tO\nthe\tO\nrebels\tO\nagreed\tO\na\tO\ntruce\tO\n,\tO\nInterfax\tT-2\nnews\tO\nagency\tO\nsaid\tO\n.\tO\n\nAt\tO\nleast\tO\n50\tO\nRussian\tT-3\nservicemen\tO\nhave\tO\nbeen\tO\nkilled\tO\nin\tO\na\tO\nbattle\tO\nwith\tO\nseparatist\tO\nrebels\tO\nwhich\tO\nerupted\tT-0\nin\tO\nthe\tO\nChechen\tT-1\ncapital\tO\nGrozny\tT-2\non\tO\nThursday\tO\nand\tO\ncontinued\tO\nafter\tO\nRussia\tB-LOC\nand\tT-4\nthe\tT-4\nrebels\tT-4\nagreed\tT-4\na\tT-4\ntruce\tT-4\n,\tO\nInterfax\tO\nnews\tO\nagency\tO\nsaid\tO\n.\tO\n\nAt\tO\nleast\tO\n50\tO\nRussian\tO\nservicemen\tO\nhave\tO\nbeen\tO\nkilled\tT-1\nin\tO\na\tO\nbattle\tO\nwith\tO\nseparatist\tO\nrebels\tO\nwhich\tO\nerupted\tO\nin\tO\nthe\tO\nChechen\tO\ncapital\tO\nGrozny\tO\non\tO\nThursday\tO\nand\tO\ncontinued\tT-2\nafter\tO\nRussia\tO\nand\tO\nthe\tO\nrebels\tO\nagreed\tT-3\na\tO\ntruce\tO\n,\tO\nInterfax\tB-ORG\nnews\tT-0\nagency\tT-4\nsaid\tO\n.\tO\n\nInterfax\tB-ORG\nquoted\tT-1\nRussian\tO\nmilitary\tT-0\ncommand\tO\nin\tO\nChechnya\tO\nas\tO\nsaying\tO\nthat\tO\nabout\tO\n200\tO\ninterior\tO\nministry\tO\nforces\tO\n,\tO\nsent\tO\non\tO\nreconaisance\tO\nmission\tO\n,\tO\nclashed\tO\nwith\tO\nrebels\tO\nat\tO\nMinutka\tO\nSquare\tO\n.\tO\n\nInterfax\tT-1\nquoted\tT-0\nRussian\tB-MISC\nmilitary\tO\ncommand\tO\nin\tO\nChechnya\tO\nas\tO\nsaying\tO\nthat\tO\nabout\tO\n200\tO\ninterior\tO\nministry\tO\nforces\tO\n,\tO\nsent\tO\non\tO\nreconaisance\tO\nmission\tO\n,\tO\nclashed\tO\nwith\tO\nrebels\tO\nat\tO\nMinutka\tO\nSquare\tO\n.\tO\n\nInterfax\tT-0\nquoted\tO\nRussian\tO\nmilitary\tT-1\ncommand\tT-1\nin\tT-2\nChechnya\tB-LOC\nas\tO\nsaying\tO\nthat\tO\nabout\tO\n200\tO\ninterior\tO\nministry\tT-3\nforces\tO\n,\tO\nsent\tO\non\tO\nreconaisance\tO\nmission\tO\n,\tO\nclashed\tO\nwith\tO\nrebels\tO\nat\tO\nMinutka\tO\nSquare\tO\n.\tO\n\nInterfax\tO\nquoted\tO\nRussian\tO\nmilitary\tO\ncommand\tT-2\nin\tO\nChechnya\tO\nas\tO\nsaying\tO\nthat\tO\nabout\tO\n200\tO\ninterior\tB-ORG\nministry\tI-ORG\nforces\tT-0\n,\tO\nsent\tT-1\non\tT-1\nreconaisance\tT-1\nmission\tT-1\n,\tO\nclashed\tT-3\nwith\tO\nrebels\tO\nat\tO\nMinutka\tO\nSquare\tO\n.\tO\n\nInterfax\tT-0\nquoted\tO\nRussian\tO\nmilitary\tO\ncommand\tO\nin\tO\nChechnya\tT-1\nas\tO\nsaying\tO\nthat\tO\nabout\tO\n200\tO\ninterior\tO\nministry\tO\nforces\tO\n,\tO\nsent\tO\non\tO\nreconaisance\tO\nmission\tO\n,\tO\nclashed\tO\nwith\tO\nrebels\tO\nat\tT-2\nMinutka\tB-LOC\nSquare\tI-LOC\n.\tO\n\nThe\tT-0\nInterfax\tB-ORG\nreport\tO\ncould\tO\nnot\tO\nbe\tO\nindependently\tO\nconfirmed\tT-1\n.\tO\n\nMoscow\tB-LOC\npeacemaker\tT-3\nAlexander\tO\nLebed\tT-0\nand\tO\nrebel\tT-1\nchief-of-staff\tO\nAslan\tO\nMaskhadov\tO\nsigned\tT-2\nan\tO\nagreement\tO\nearlier\tO\non\tO\nThursday\tO\nunder\tO\nwhich\tO\nthe\tO\ntwo\tO\nsides\tO\nwould\tO\ncease\tO\nall\tO\nhostilities\tO\nat\tO\nnoon\tO\n(\tO\n0800\tO\nGMT\tO\n)\tO\non\tO\nFriday\tO\n.\tO\n\nMoscow\tT-2\npeacemaker\tT-2\nAlexander\tB-PER\nLebed\tI-PER\nand\tO\nrebel\tO\nchief-of-staff\tO\nAslan\tO\nMaskhadov\tO\nsigned\tT-3\nan\tT-3\nagreement\tT-3\nearlier\tO\non\tO\nThursday\tO\nunder\tO\nwhich\tO\nthe\tO\ntwo\tO\nsides\tO\nwould\tO\ncease\tT-0\nall\tO\nhostilities\tO\nat\tO\nnoon\tO\n(\tO\n0800\tO\nGMT\tO\n)\tO\non\tO\nFriday\tO\n.\tO\n\nMoscow\tT-3\npeacemaker\tT-0\nAlexander\tT-1\nLebed\tO\nand\tO\nrebel\tO\nchief-of-staff\tT-2\nAslan\tB-PER\nMaskhadov\tI-PER\nsigned\tO\nan\tO\nagreement\tO\nearlier\tO\non\tO\nThursday\tO\nunder\tO\nwhich\tO\nthe\tO\ntwo\tO\nsides\tO\nwould\tO\ncease\tO\nall\tO\nhostilities\tT-4\nat\tO\nnoon\tO\n(\tO\n0800\tO\nGMT\tO\n)\tO\non\tO\nFriday\tO\n.\tO\n\nMoscow\tO\npeacemaker\tO\nAlexander\tO\nLebed\tO\nand\tO\nrebel\tO\nchief-of-staff\tO\nAslan\tO\nMaskhadov\tO\nsigned\tO\nan\tO\nagreement\tO\nearlier\tO\non\tO\nThursday\tO\nunder\tO\nwhich\tO\nthe\tO\ntwo\tO\nsides\tO\nwould\tO\ncease\tO\nall\tO\nhostilities\tO\nat\tT-0\nnoon\tT-0\n(\tO\n0800\tO\nGMT\tB-MISC\n)\tO\non\tO\nFriday\tO\n.\tO\n\nInterfax\tB-ORG\nmade\tT-1\nclear\tO\nthat\tO\nthe\tO\ninterior\tO\nministry\tT-0\ndetachment\tO\nhad\tO\nbeen\tO\nsent\tO\non\tO\nthe\tO\nmission\tO\nbefore\tO\nthe\tO\ntruce\tO\ndeal\tO\nhad\tO\nbeen\tO\nsigned\tO\nat\tO\nthe\tO\nlocal\tO\nequivalent\tO\nof\tO\n1500\tT-2\nGMT\tT-2\n.\tO\n\nInterfax\tT-1\nmade\tO\nclear\tO\nthat\tT-0\nthe\tO\ninterior\tB-ORG\nministry\tI-ORG\ndetachment\tO\nhad\tO\nbeen\tO\nsent\tO\non\tO\nthe\tO\nmission\tO\nbefore\tO\nthe\tO\ntruce\tO\ndeal\tO\nhad\tO\nbeen\tO\nsigned\tO\nat\tO\nthe\tO\nlocal\tO\nequivalent\tO\nof\tO\n1500\tO\nGMT\tO\n.\tT-0\n\nInterfax\tT-2\nmade\tO\nclear\tT-0\nthat\tO\nthe\tO\ninterior\tO\nministry\tO\ndetachment\tT-3\nhad\tO\nbeen\tO\nsent\tT-1\non\tO\nthe\tO\nmission\tO\nbefore\tO\nthe\tO\ntruce\tO\ndeal\tO\nhad\tO\nbeen\tO\nsigned\tO\nat\tO\nthe\tO\nlocal\tO\nequivalent\tO\nof\tO\n1500\tO\nGMT\tB-MISC\n.\tO\n\nBut\tO\nfierce\tO\nfighting\tT-1\nstill\tO\nraged\tO\nat\tT-0\n1600\tT-0\nGMT\tB-MISC\n,\tO\nInterfax\tT-2\nsaid\tO\n.\tO\n\nBut\tO\nfierce\tO\nfighting\tO\nstill\tO\nraged\tO\nat\tO\n1600\tT-1\nGMT\tT-1\n,\tO\nInterfax\tB-ORG\nsaid\tT-0\n.\tO\n\nIt\tT-1\nquoted\tT-1\na\tO\nsource\tO\nin\tT-0\nthe\tT-0\nRussian\tB-MISC\ncommand\tO\nin\tO\nChechnya\tT-2\nas\tO\nsaying\tO\nthat\tO\nthe\tO\nservicemen\tO\nwere\tO\noutnumbered\tO\nby\tO\nthe\tO\nrebels\tT-3\n.\tT-3\n\nIt\tO\nquoted\tO\na\tO\nsource\tO\nin\tO\nthe\tO\nRussian\tT-2\ncommand\tT-2\nin\tT-0\nChechnya\tB-LOC\nas\tO\nsaying\tO\nthat\tO\nthe\tO\nservicemen\tT-1\nwere\tO\noutnumbered\tT-3\nby\tO\nthe\tO\nrebels\tO\n.\tO\n\nPolish\tB-MISC\nschoolgirl\tT-1\nblackmailer\tT-0\nwanted\tO\ntextbooks\tO\n.\tO\n\nGDANSK\tB-LOC\n,\tO\nPoland\tT-0\n1996-08-22\tO\n\nGDANSK\tT-0\n,\tO\nPoland\tB-LOC\n1996-08-22\tO\n\nA\tO\nPolish\tB-MISC\nschoolgirl\tT-0\nblackmailed\tO\ntwo\tO\nwomen\tO\nwith\tO\nanonymous\tO\nletters\tO\nthreatening\tT-1\ndeath\tO\nand\tO\nlater\tO\nexplained\tO\nthat\tO\nshe\tO\nneeded\tO\nmoney\tO\nfor\tO\ntextbooks\tO\n,\tO\npolice\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nThe\tO\n13-year-old\tO\ngirl\tO\ntried\tO\nto\tO\nextract\tO\n60\tO\nand\tO\n70\tO\nzlotys\tO\n(\tO\n$\tO\n22\tO\nand\tO\n$\tO\n26\tO\n)\tO\nfrom\tO\ntwo\tO\nresidents\tT-0\nof\tO\nSierakowice\tB-LOC\nby\tO\nthreatening\tO\nto\tO\ntake\tO\ntheir\tO\nlives\tO\n,\tO\n\"\tO\na\tO\npolice\tO\nspokesman\tO\nsaid\tO\nin\tO\nthe\tO\nnearby\tO\nnorthern\tO\ncity\tO\nof\tO\nGdansk\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nThe\tO\n13-year-old\tO\ngirl\tO\ntried\tO\nto\tO\nextract\tO\n60\tO\nand\tO\n70\tO\nzlotys\tO\n(\tO\n$\tO\n22\tO\nand\tO\n$\tO\n26\tO\n)\tO\nfrom\tO\ntwo\tO\nresidents\tO\nof\tO\nSierakowice\tO\nby\tO\nthreatening\tT-1\nto\tO\ntake\tO\ntheir\tO\nlives\tO\n,\tO\n\"\tO\na\tO\npolice\tO\nspokesman\tO\nsaid\tO\nin\tO\nthe\tO\nnearby\tT-0\nnorthern\tT-0\ncity\tT-0\nof\tO\nGdansk\tB-LOC\non\tO\nThursday\tT-2\n.\tO\n\nHe\tO\nsaid\tT-0\nthe\tO\nwomen\tT-3\nreported\tO\nthe\tO\nblackmail\tT-1\nletters\tO\nand\tO\npolice\tO\ncaught\tT-2\nthe\tO\ngirl\tO\non\tO\nWednesday\tO\nas\tO\nshe\tO\ntried\tO\nto\tO\npick\tO\nup\tO\nthe\tO\ncash\tO\nat\tO\nthe\tO\nSierakowice\tB-LOC\nrailway\tT-4\nstation\tT-4\n.\tO\n\n\"\tO\nInterviewed\tT-1\nin\tO\nthe\tO\npresence\tO\nof\tO\na\tO\npsychologist\tT-0\n,\tO\nshe\tO\nsaid\tO\nshe\tO\nwanted\tO\nto\tO\nuse\tO\nthe\tO\nmoney\tO\nfor\tO\nschool\tO\nbooks\tO\nand\tO\nclothes\tO\n,\tO\n\"\tO\nspokesman\tO\nKazimierz\tB-PER\nSocha\tI-PER\ntold\tO\nReuters\tO\n.\tO\n\n\"\tO\nInterviewed\tO\nin\tO\nthe\tO\npresence\tO\nof\tO\na\tO\npsychologist\tO\n,\tO\nshe\tO\nsaid\tT-0\nshe\tO\nwanted\tO\nto\tO\nuse\tO\nthe\tO\nmoney\tO\nfor\tO\nschool\tO\nbooks\tO\nand\tO\nclothes\tO\n,\tO\n\"\tO\nspokesman\tO\nKazimierz\tO\nSocha\tT-1\ntold\tT-2\nReuters\tB-ORG\n.\tO\n\nCzech\tB-MISC\nCNB-120\tO\nindex\tT-0\nrises\tO\n1.2\tO\npts\tO\nto\tO\n869.3\tO\n.\tO\n\nCzech\tT-2\nCNB-120\tB-MISC\nindex\tO\nrises\tT-0\n1.2\tO\npts\tO\nto\tO\n869.3\tT-1\n.\tO\n\nThe\tO\nCNB-120\tB-MISC\nindex\tT-1\n,\tO\na\tO\nbroad\tO\ndaily\tO\nmeasure\tO\nof\tO\nCzech\tO\nequities\tT-2\n,\tO\nrose\tO\n1.2\tO\npoints\tO\non\tO\nThursday\tO\nto\tO\n869.3\tO\n,\tO\nthe\tT-0\nCzech\tT-0\nNational\tT-0\nBank\tT-0\n(\tT-0\nCNB\tT-0\n)\tT-0\nsaid\tO\n.\tO\n\nThe\tO\nCNB-120\tO\nindex\tT-1\n,\tO\na\tO\nbroad\tO\ndaily\tT-2\nmeasure\tT-2\nof\tO\nCzech\tB-MISC\nequities\tO\n,\tO\nrose\tO\n1.2\tO\npoints\tO\non\tO\nThursday\tO\nto\tO\n869.3\tO\n,\tO\nthe\tO\nCzech\tT-0\nNational\tT-0\nBank\tT-0\n(\tO\nCNB\tO\n)\tO\nsaid\tO\n.\tO\n\nThe\tO\nCNB-120\tT-2\nindex\tO\n,\tO\na\tO\nbroad\tO\ndaily\tO\nmeasure\tO\nof\tO\nCzech\tO\nequities\tO\n,\tO\nrose\tT-1\n1.2\tT-1\npoints\tT-1\non\tO\nThursday\tO\nto\tO\n869.3\tO\n,\tO\nthe\tO\nCzech\tB-ORG\nNational\tI-ORG\nBank\tI-ORG\n(\tO\nCNB\tO\n)\tO\nsaid\tT-0\n.\tT-2\n\nThe\tO\nCNB-120\tO\nindex\tO\n,\tO\na\tO\nbroad\tO\ndaily\tO\nmeasure\tO\nof\tO\nCzech\tO\nequities\tO\n,\tO\nrose\tO\n1.2\tO\npoints\tO\non\tO\nThursday\tO\nto\tO\n869.3\tO\n,\tO\nthe\tO\nCzech\tT-1\nNational\tT-1\nBank\tT-1\n(\tO\nCNB\tB-ORG\n)\tO\nsaid\tT-0\n.\tO\n\n--\tO\nPrague\tB-ORG\nNewsroom\tI-ORG\n,\tO\n42-2-2423-0003\tT-0\n\nRussians\tB-MISC\n,\tO\nrebels\tO\nsign\tT-0\ndeal\tO\nin\tO\nChechnya\tO\n.\tO\n\nRussians\tT-1\n,\tO\nrebels\tO\nsign\tT-2\ndeal\tO\nin\tT-0\nChechnya\tB-LOC\n.\tO\n\nNOVYE\tB-LOC\nATAGI\tI-LOC\n,\tO\nRussia\tT-0\n1996-08-22\tO\n\nNOVYE\tT-0\nATAGI\tT-0\n,\tO\nRussia\tB-LOC\n1996-08-22\tT-1\n\nRussian\tB-MISC\nPresident\tT-0\nBoris\tO\nYeltsin\tO\n's\tO\nsecurity\tO\nsupremo\tO\nAlexander\tO\nLebed\tO\nand\tO\nChechen\tO\nrebel\tT-1\nchief-of-staff\tO\nAslan\tO\nMaskhadov\tO\nsigned\tT-2\na\tT-2\ndeal\tT-2\non\tO\nThursday\tO\naimed\tO\nat\tO\nending\tO\nthree\tO\nweeks\tO\nof\tO\nrenewed\tO\nfighting\tO\nin\tO\nthe\tO\nregion\tO\n.\tO\n\nRussian\tO\nPresident\tO\nBoris\tB-PER\nYeltsin\tI-PER\n's\tO\nsecurity\tT-0\nsupremo\tO\nAlexander\tO\nLebed\tO\nand\tO\nChechen\tO\nrebel\tO\nchief-of-staff\tO\nAslan\tO\nMaskhadov\tO\nsigned\tO\na\tO\ndeal\tO\non\tO\nThursday\tO\naimed\tO\nat\tO\nending\tO\nthree\tO\nweeks\tO\nof\tO\nrenewed\tO\nfighting\tO\nin\tO\nthe\tO\nregion\tO\n.\tO\n\nRussian\tT-1\nPresident\tT-1\nBoris\tT-1\nYeltsin\tT-1\n's\tT-1\nsecurity\tT-2\nsupremo\tT-2\nAlexander\tB-PER\nLebed\tI-PER\nand\tO\nChechen\tT-3\nrebel\tT-3\nchief-of-staff\tT-3\nAslan\tT-3\nMaskhadov\tT-3\nsigned\tO\na\tO\ndeal\tO\non\tO\nThursday\tO\naimed\tO\nat\tO\nending\tO\nthree\tO\nweeks\tO\nof\tO\nrenewed\tO\nfighting\tO\nin\tO\nthe\tO\nregion\tO\n.\tO\n\nRussian\tT-2\nPresident\tT-2\nBoris\tO\nYeltsin\tO\n's\tO\nsecurity\tT-1\nsupremo\tT-1\nAlexander\tT-1\nLebed\tT-1\nand\tT-1\nChechen\tB-MISC\nrebel\tT-0\nchief-of-staff\tT-0\nAslan\tT-0\nMaskhadov\tT-0\nsigned\tO\na\tO\ndeal\tO\non\tO\nThursday\tO\naimed\tO\nat\tO\nending\tO\nthree\tO\nweeks\tO\nof\tO\nrenewed\tO\nfighting\tT-3\nin\tO\nthe\tO\nregion\tO\n.\tO\n\nRussian\tO\nPresident\tO\nBoris\tT-0\nYeltsin\tT-1\n's\tO\nsecurity\tO\nsupremo\tO\nAlexander\tO\nLebed\tT-2\nand\tO\nChechen\tO\nrebel\tO\nchief-of-staff\tT-3\nAslan\tB-PER\nMaskhadov\tI-PER\nsigned\tT-4\na\tO\ndeal\tO\non\tO\nThursday\tO\naimed\tO\nat\tO\nending\tO\nthree\tO\nweeks\tO\nof\tO\nrenewed\tO\nfighting\tO\nin\tO\nthe\tO\nregion\tO\n.\tO\n\nThe\tO\nfinal\tO\ncontents\tO\nof\tO\nthe\tO\ndocument\tO\nnegotiated\tT-1\nin\tO\nthis\tO\nvillage\tO\nsouth\tO\nof\tO\nthe\tO\nChechen\tB-MISC\ncapital\tT-0\nGrozny\tO\nhave\tO\nnot\tO\nbeen\tO\nofficially\tO\ndisclosed\tO\n.\tO\n\nThe\tO\nfinal\tO\ncontents\tT-0\nof\tO\nthe\tO\ndocument\tO\nnegotiated\tT-1\nin\tO\nthis\tO\nvillage\tT-2\nsouth\tO\nof\tO\nthe\tO\nChechen\tO\ncapital\tO\nGrozny\tB-LOC\nhave\tO\nnot\tO\nbeen\tO\nofficially\tO\ndisclosed\tO\n.\tO\n\nItar-Tass\tB-ORG\nnews\tO\nagency\tT-0\nsaid\tT-1\nit\tO\nprovided\tO\nfor\tO\nthe\tO\ndisengagement\tO\nof\tO\nRussian\tT-2\nand\tO\nrebel\tO\nforces\tO\nin\tO\nChechnya\tT-3\n.\tO\n\nItar-Tass\tO\nnews\tO\nagency\tO\nsaid\tO\nit\tO\nprovided\tT-0\nfor\tO\nthe\tO\ndisengagement\tT-2\nof\tT-2\nRussian\tB-MISC\nand\tO\nrebel\tO\nforces\tO\nin\tT-3\nChechnya\tT-1\n.\tO\n\nItar-Tass\tO\nnews\tO\nagency\tO\nsaid\tO\nit\tO\nprovided\tO\nfor\tO\nthe\tO\ndisengagement\tT-0\nof\tO\nRussian\tO\nand\tO\nrebel\tO\nforces\tT-1\nin\tO\nChechnya\tB-LOC\n.\tO\n\nLebed\tB-PER\naide\tO\nsays\tO\nRussian-Chechen\tT-0\ntalks\tO\ngoing\tO\nwell\tO\n.\tO\n\nLebed\tT-1\naide\tO\nsays\tT-0\nRussian-Chechen\tB-MISC\ntalks\tT-2\ngoing\tO\nwell\tO\n.\tO\n\nNOVYE\tB-LOC\nATAGI\tI-LOC\n,\tO\nRussia\tT-0\n1996-08-22\tO\n\nNOVYE\tT-0\nATAGI\tT-0\n,\tO\nRussia\tB-LOC\n1996-08-22\tT-1\n\nTalks\tT-2\nbetween\tO\nRussia\tB-LOC\n's\tO\nAlexander\tT-0\nLebed\tT-0\nand\tO\nChechen\tT-1\nseparatist\tT-3\nleaders\tT-3\nwere\tO\ngoing\tO\nwell\tO\non\tO\nThursday\tO\nand\tO\nthe\tO\ntwo\tO\nsides\tO\nwere\tO\nworking\tO\nout\tO\na\tO\ndetailed\tO\nschedule\tO\non\tO\nhow\tO\nto\tO\nstop\tO\nthe\tO\nwar\tO\n,\tO\na\tO\nLebed\tO\naide\tO\nsaid\tO\n.\tO\n\nTalks\tO\nbetween\tT-2\nRussia\tT-0\n's\tT-0\nAlexander\tB-PER\nLebed\tI-PER\nand\tO\nChechen\tT-1\nseparatist\tT-3\nleaders\tO\nwere\tO\ngoing\tO\nwell\tO\non\tO\nThursday\tO\nand\tO\nthe\tO\ntwo\tO\nsides\tO\nwere\tO\nworking\tO\nout\tO\na\tO\ndetailed\tO\nschedule\tO\non\tO\nhow\tO\nto\tO\nstop\tO\nthe\tO\nwar\tO\n,\tO\na\tO\nLebed\tO\naide\tO\nsaid\tO\n.\tO\n\nTalks\tO\nbetween\tO\nRussia\tO\n's\tO\nAlexander\tT-1\nLebed\tT-1\nand\tO\nChechen\tB-MISC\nseparatist\tT-0\nleaders\tT-0\nwere\tO\ngoing\tO\nwell\tO\non\tO\nThursday\tO\nand\tO\nthe\tO\ntwo\tO\nsides\tO\nwere\tO\nworking\tO\nout\tO\na\tO\ndetailed\tO\nschedule\tO\non\tO\nhow\tO\nto\tO\nstop\tO\nthe\tO\nwar\tO\n,\tO\na\tO\nLebed\tO\naide\tO\nsaid\tO\n.\tO\n\nTalks\tO\nbetween\tO\nRussia\tO\n's\tO\nAlexander\tO\nLebed\tO\nand\tO\nChechen\tO\nseparatist\tO\nleaders\tO\nwere\tO\ngoing\tO\nwell\tO\non\tO\nThursday\tO\nand\tO\nthe\tO\ntwo\tO\nsides\tO\nwere\tO\nworking\tO\nout\tO\na\tO\ndetailed\tO\nschedule\tO\non\tO\nhow\tO\nto\tO\nstop\tO\nthe\tO\nwar\tO\n,\tO\na\tO\nLebed\tB-PER\naide\tT-0\nsaid\tO\n.\tO\n\nPress\tO\nspokesman\tO\nAlexander\tB-PER\nBarkhatov\tI-PER\ntold\tT-1\nreporters\tO\nthe\tO\nnegotiations\tO\n,\tO\nbeing\tO\nheld\tO\nat\tO\nthis\tO\nrebel-held\tO\nvillage\tO\nsome\tO\n20\tO\nkm\tO\n(\tO\n12\tO\nmiles\tO\n)\tO\nsouth\tO\nof\tO\nthe\tO\nChechen\tO\ncapital\tO\nGrozny\tO\n,\tO\nwere\tO\nprogressing\tO\nbriskly\tO\nand\tO\nbeing\tO\nconducted\tT-0\nin\tO\na\tO\ngood\tO\nmood\tO\n.\tO\n\nPress\tO\nspokesman\tO\nAlexander\tO\nBarkhatov\tO\ntold\tO\nreporters\tO\nthe\tO\nnegotiations\tO\n,\tO\nbeing\tO\nheld\tO\nat\tO\nthis\tO\nrebel-held\tO\nvillage\tO\nsome\tO\n20\tO\nkm\tO\n(\tO\n12\tO\nmiles\tO\n)\tO\nsouth\tO\nof\tT-4\nthe\tT-4\nChechen\tB-MISC\ncapital\tT-0\nGrozny\tT-1\n,\tO\nwere\tO\nprogressing\tT-2\nbriskly\tO\nand\tO\nbeing\tO\nconducted\tT-3\nin\tO\na\tO\ngood\tO\nmood\tO\n.\tO\n\nPress\tT-0\nspokesman\tT-0\nAlexander\tO\nBarkhatov\tO\ntold\tO\nreporters\tT-2\nthe\tO\nnegotiations\tO\n,\tO\nbeing\tO\nheld\tO\nat\tO\nthis\tO\nrebel-held\tO\nvillage\tO\nsome\tO\n20\tO\nkm\tO\n(\tO\n12\tO\nmiles\tO\n)\tO\nsouth\tO\nof\tO\nthe\tO\nChechen\tT-1\ncapital\tT-1\nGrozny\tB-LOC\n,\tO\nwere\tO\nprogressing\tO\nbriskly\tO\nand\tO\nbeing\tO\nconducted\tO\nin\tO\na\tO\ngood\tO\nmood\tO\n.\tO\n\nHe\tO\nsaid\tT-0\na\tO\ndocument\tO\nwould\tO\nbe\tO\ncompleted\tO\nin\tO\nan\tO\nhour\tO\n's\tO\ntime\tO\nfor\tO\nsignature\tO\nby\tO\nthe\tO\ntwo\tO\nsides\tO\n,\tO\nwho\tO\nwere\tO\nworking\tO\non\tO\na\tO\n\"\tO\nday-by-day\tT-3\nschedule\tO\nto\tO\nstop\tT-1\nthe\tO\nwar\tT-2\nin\tO\nChechnya\tB-LOC\n.\tO\n\"\tO\n\nYeltsin\tB-PER\nshown\tT-1\non\tO\nRussian\tT-0\ntelevision\tT-0\n.\tO\n\nYeltsin\tO\nshown\tT-0\non\tT-0\nRussian\tB-MISC\ntelevision\tT-1\n.\tO\n\nRussian\tB-MISC\ntelevision\tO\nshowed\tT-2\na\tO\nbrief\tO\nclip\tT-1\nof\tO\nBoris\tO\nYeltsin\tO\non\tO\nThursday\tO\n,\tO\nwith\tO\nthe\tO\npresident\tO\nlaughing\tO\nand\tO\nsmiling\tO\nas\tO\nhe\tO\nspoke\tO\nto\tO\nnominee\tO\nhealth\tO\nminister\tO\nTatyana\tT-0\nDmitrieva\tT-0\n.\tO\n\nRussian\tT-2\ntelevision\tT-1\nshowed\tO\na\tO\nbrief\tO\nclip\tT-0\nof\tT-0\nBoris\tB-PER\nYeltsin\tI-PER\non\tO\nThursday\tO\n,\tO\nwith\tO\nthe\tO\npresident\tO\nlaughing\tO\nand\tO\nsmiling\tO\nas\tO\nhe\tO\nspoke\tO\nto\tO\nnominee\tT-3\nhealth\tO\nminister\tO\nTatyana\tT-4\nDmitrieva\tT-4\n.\tO\n\nRussian\tO\ntelevision\tO\nshowed\tO\na\tO\nbrief\tO\nclip\tO\nof\tO\nBoris\tO\nYeltsin\tO\non\tO\nThursday\tO\n,\tO\nwith\tO\nthe\tO\npresident\tO\nlaughing\tO\nand\tO\nsmiling\tO\nas\tO\nhe\tO\nspoke\tO\nto\tO\nnominee\tO\nhealth\tO\nminister\tT-0\nTatyana\tB-PER\nDmitrieva\tI-PER\n.\tO\n\nHe\tO\nreturned\tT-0\nto\tT-0\nthe\tO\nKremlin\tB-LOC\non\tO\nThursday\tO\nafter\tO\na\tO\ntwo-day\tT-1\nbreak\tT-1\nin\tO\nthe\tO\nlakelands\tT-2\nof\tO\nnorthwestern\tO\nRussia\tO\n.\tO\n\nHe\tO\nreturned\tT-1\nto\tO\nthe\tO\nKremlin\tO\non\tO\nThursday\tO\nafter\tO\na\tO\ntwo-day\tO\nbreak\tO\nin\tO\nthe\tO\nlakelands\tT-2\nof\tO\nnorthwestern\tT-0\nRussia\tB-LOC\n.\tO\n\nPRESS\tT-0\nDIGEST\tT-0\n-\tO\nBosnia\tB-LOC\n-\tO\nAug\tO\n22\tO\n.\tO\n\nThese\tO\nare\tO\nthe\tO\nleading\tT-0\nstories\tT-3\nin\tT-1\nthe\tT-1\nSarajevo\tB-LOC\npress\tT-2\non\tO\nThursday\tO\n.\tO\n\nReuters\tB-ORG\nhas\tO\nnot\tO\nverified\tT-0\nthese\tO\nstories\tO\nand\tO\ndoes\tO\nnot\tO\nvouch\tO\nfor\tO\ntheir\tO\naccuracy\tO\n.\tO\n\n-\tO\nThe\tO\nBosnian\tB-MISC\nfederation\tT-0\nlaunches\tT-2\na\tO\ncommon\tO\npayment\tT-1\nsystem\tO\non\tO\nFriday\tO\n.\tO\n\nUnder\tO\nthe\tO\nnew\tO\nsystem\tO\ntaxes\tO\nand\tO\ncustoms\tO\nmay\tO\nbe\tO\npaid\tO\nin\tT-3\nthe\tT-3\nBosnian\tB-MISC\ndinar\tT-4\n,\tO\nthe\tO\nCroatian\tT-1\nkuna\tO\nor\tO\nthe\tO\nDeutsche\tT-0\nmark\tT-0\nuntil\tO\na\tO\nnew\tO\nBosnian\tT-2\ncurrency\tO\nis\tO\nintroduced\tO\n.\tO\n\nUnder\tT-3\nthe\tO\nnew\tO\nsystem\tO\ntaxes\tO\nand\tO\ncustoms\tO\nmay\tO\nbe\tO\npaid\tO\nin\tO\nthe\tO\nBosnian\tT-1\ndinar\tO\n,\tO\nthe\tO\nCroatian\tB-MISC\nkuna\tT-0\nor\tO\nthe\tO\nDeutsche\tT-2\nmark\tO\nuntil\tO\na\tO\nnew\tO\nBosnian\tO\ncurrency\tO\nis\tO\nintroduced\tO\n.\tO\n\nUnder\tO\nthe\tO\nnew\tO\nsystem\tO\ntaxes\tO\nand\tO\ncustoms\tO\nmay\tO\nbe\tO\npaid\tT-0\nin\tO\nthe\tO\nBosnian\tO\ndinar\tO\n,\tO\nthe\tO\nCroatian\tO\nkuna\tO\nor\tO\nthe\tO\nDeutsche\tT-2\nmark\tO\nuntil\tO\na\tO\nnew\tO\nBosnian\tB-MISC\ncurrency\tO\nis\tO\nintroduced\tT-1\n.\tO\n\n-\tO\nThe\tO\npresident\tO\nof\tO\nthe\tO\nBosnian\tB-ORG\nAssociation\tI-ORG\nfor\tI-ORG\nRefugees\tI-ORG\nand\tI-ORG\nDisplaced\tI-ORG\nPersons\tI-ORG\n,\tO\nMirhunisa\tO\nKomarica\tO\nsays\tO\nmany\tO\nsurvivors\tO\nof\tO\nthe\tO\n1995\tO\nmassacre\tO\nin\tO\nthe\tO\nBosnian\tO\ntown\tO\nof\tO\nSrebrenica\tT-0\nare\tO\nlanguishing\tO\nas\tO\nforced\tO\nlaborers\tO\nin\tO\nSerbian\tO\nmines\tO\n.\tO\n\n-\tO\nThe\tO\npresident\tT-0\nof\tO\nthe\tO\nBosnian\tT-1\nAssociation\tO\nfor\tO\nRefugees\tT-2\nand\tO\nDisplaced\tO\nPersons\tO\n,\tO\nMirhunisa\tB-PER\nKomarica\tI-PER\nsays\tO\nmany\tO\nsurvivors\tO\nof\tO\nthe\tO\n1995\tO\nmassacre\tO\nin\tO\nthe\tO\nBosnian\tO\ntown\tO\nof\tO\nSrebrenica\tO\nare\tO\nlanguishing\tO\nas\tO\nforced\tO\nlaborers\tO\nin\tO\nSerbian\tO\nmines\tO\n.\tO\n\n-\tO\nThe\tO\npresident\tO\nof\tO\nthe\tO\nBosnian\tO\nAssociation\tO\nfor\tO\nRefugees\tO\nand\tO\nDisplaced\tO\nPersons\tO\n,\tO\nMirhunisa\tO\nKomarica\tO\nsays\tO\nmany\tO\nsurvivors\tT-1\nof\tO\nthe\tO\n1995\tT-0\nmassacre\tT-0\nin\tO\nthe\tO\nBosnian\tB-MISC\ntown\tT-2\nof\tO\nSrebrenica\tT-3\nare\tO\nlanguishing\tO\nas\tO\nforced\tO\nlaborers\tO\nin\tO\nSerbian\tO\nmines\tO\n.\tO\n\n-\tO\nThe\tO\npresident\tO\nof\tO\nthe\tO\nBosnian\tT-0\nAssociation\tT-0\nfor\tT-0\nRefugees\tT-0\nand\tO\nDisplaced\tO\nPersons\tO\n,\tO\nMirhunisa\tT-3\nKomarica\tT-3\nsays\tO\nmany\tO\nsurvivors\tO\nof\tO\nthe\tO\n1995\tT-1\nmassacre\tT-1\nin\tO\nthe\tO\nBosnian\tT-2\ntown\tT-2\nof\tO\nSrebrenica\tB-LOC\nare\tO\nlanguishing\tO\nas\tO\nforced\tO\nlaborers\tO\nin\tO\nSerbian\tO\nmines\tO\n.\tO\n\n-\tO\nThe\tO\npresident\tO\nof\tO\nthe\tO\nBosnian\tO\nAssociation\tO\nfor\tO\nRefugees\tO\nand\tO\nDisplaced\tO\nPersons\tO\n,\tO\nMirhunisa\tT-1\nKomarica\tT-1\nsays\tO\nmany\tO\nsurvivors\tO\nof\tO\nthe\tO\n1995\tO\nmassacre\tT-2\nin\tO\nthe\tO\nBosnian\tO\ntown\tO\nof\tO\nSrebrenica\tO\nare\tO\nlanguishing\tT-3\nas\tO\nforced\tO\nlaborers\tT-0\nin\tO\nSerbian\tB-MISC\nmines\tO\n.\tO\n\nAccording\tT-0\nto\tT-0\nKomarica\tB-PER\n,\tO\n2,400\tO\nmale\tO\nresidents\tO\nof\tO\nSrebrenica\tO\nwork\tO\nin\tO\nthe\tO\nTrepca\tO\nmine\tO\nand\tO\n1,900\tO\nwork\tO\nin\tO\na\tO\nmine\tO\nin\tO\nAleksandrovac\tO\n.\tO\n\nAccording\tO\nto\tO\nKomarica\tO\n,\tO\n2,400\tO\nmale\tO\nresidents\tO\nof\tT-1\nSrebrenica\tB-LOC\nwork\tT-0\nin\tO\nthe\tO\nTrepca\tO\nmine\tO\nand\tO\n1,900\tO\nwork\tO\nin\tO\na\tO\nmine\tO\nin\tO\nAleksandrovac\tO\n.\tO\n\nAccording\tO\nto\tO\nKomarica\tT-1\n,\tO\n2,400\tO\nmale\tO\nresidents\tO\nof\tO\nSrebrenica\tO\nwork\tT-0\nin\tO\nthe\tO\nTrepca\tB-LOC\nmine\tO\nand\tO\n1,900\tO\nwork\tO\nin\tO\na\tO\nmine\tO\nin\tO\nAleksandrovac\tO\n.\tO\n\nAccording\tO\nto\tO\nKomarica\tO\n,\tO\n2,400\tO\nmale\tO\nresidents\tT-1\nof\tO\nSrebrenica\tO\nwork\tO\nin\tO\nthe\tO\nTrepca\tO\nmine\tO\nand\tO\n1,900\tO\nwork\tO\nin\tO\na\tO\nmine\tT-0\nin\tO\nAleksandrovac\tB-LOC\n.\tO\n\n-\tO\nSlovenian\tB-MISC\npolice\tT-0\nbriefly\tO\ndetain\tO\ntwo\tO\nBosnian\tO\nopposition\tO\nleaders\tO\nin\tO\nLjubljana\tO\nand\tO\ncancel\tO\nopposition\tO\npolitical\tO\nrallies\tO\nin\tO\nLjubljana\tO\nand\tO\nMaribor\tO\n.\tO\n\n-\tO\nSlovenian\tO\npolice\tO\nbriefly\tO\ndetain\tT-1\ntwo\tT-1\nBosnian\tB-MISC\nopposition\tT-0\nleaders\tO\nin\tO\nLjubljana\tO\nand\tO\ncancel\tO\nopposition\tO\npolitical\tO\nrallies\tO\nin\tO\nLjubljana\tO\nand\tO\nMaribor\tO\n.\tO\n\n-\tO\nSlovenian\tO\npolice\tO\nbriefly\tO\ndetain\tO\ntwo\tO\nBosnian\tO\nopposition\tO\nleaders\tO\nin\tO\nLjubljana\tB-LOC\nand\tO\ncancel\tO\nopposition\tO\npolitical\tO\nrallies\tT-0\nin\tO\nLjubljana\tO\nand\tO\nMaribor\tO\n.\tO\n\n-\tO\nSlovenian\tO\npolice\tO\nbriefly\tO\ndetain\tT-1\ntwo\tO\nBosnian\tO\nopposition\tO\nleaders\tO\nin\tO\nLjubljana\tO\nand\tO\ncancel\tT-0\nopposition\tO\npolitical\tO\nrallies\tT-2\nin\tT-2\nLjubljana\tB-LOC\nand\tO\nMaribor\tO\n.\tO\n\n-\tO\nSlovenian\tT-2\npolice\tO\nbriefly\tO\ndetain\tO\ntwo\tO\nBosnian\tO\nopposition\tO\nleaders\tO\nin\tO\nLjubljana\tT-0\nand\tO\ncancel\tO\nopposition\tT-1\npolitical\tO\nrallies\tO\nin\tO\nLjubljana\tT-3\nand\tO\nMaribor\tB-LOC\n.\tO\n\n--\tO\nSarajevo\tB-LOC\nnewsroom\tT-0\n,\tO\n+387-71-663-864\tO\n.\tO\n\nGrozny\tB-LOC\nquiet\tT-2\novernight\tO\nafter\tT-0\nraids\tT-1\n.\tO\n\nALKHAN-YURT\tB-LOC\n,\tO\nRussia\tT-0\n1996-08-22\tO\n\nALKHAN-YURT\tT-0\n,\tO\nRussia\tB-LOC\n1996-08-22\tO\n\nThe\tO\ncity\tO\nof\tO\nGrozny\tB-LOC\n,\tO\npounded\tO\nby\tO\nRussian\tO\nplanes\tT-0\nand\tO\nartillery\tO\nfor\tO\nhours\tO\non\tO\nWednesday\tO\n,\tO\ncalmed\tO\ndown\tO\novernight\tO\n,\tO\nalthough\tO\nsporadic\tO\nexplosions\tO\nand\tO\nshooting\tO\ncould\tO\nstill\tO\nbe\tO\nheard\tO\n.\tO\n\nThe\tO\ncity\tT-1\nof\tT-1\nGrozny\tT-1\n,\tO\npounded\tT-2\nby\tO\nRussian\tB-MISC\nplanes\tO\nand\tO\nartillery\tT-3\nfor\tO\nhours\tO\non\tO\nWednesday\tO\n,\tO\ncalmed\tO\ndown\tO\novernight\tO\n,\tO\nalthough\tO\nsporadic\tO\nexplosions\tT-4\nand\tO\nshooting\tT-0\ncould\tO\nstill\tO\nbe\tO\nheard\tO\n.\tO\n\nReuters\tO\ncorrespondent\tT-0\nLawrence\tB-PER\nSheets\tI-PER\n,\tO\nspeaking\tT-1\nfrom\tO\nthe\tO\nnearby\tO\nvillage\tO\nof\tO\nAlkhan-Yurt\tT-2\n,\tO\nsaid\tT-4\nhe\tO\nhad\tO\nheard\tO\nlittle\tO\nfrom\tO\nGrozny\tT-3\nsince\tO\nWednesday\tO\nevening\tO\n's\tO\narrival\tO\nof\tO\nRussian\tO\nsecurity\tO\nchief\tO\nAlexander\tO\nLebed\tO\n,\tO\nwho\tO\nsaid\tO\nhe\tO\n\"\tO\ncame\tT-5\nwith\tT-5\npeace\tT-5\n\"\tO\n.\tO\n\nReuters\tO\ncorrespondent\tO\nLawrence\tO\nSheets\tO\n,\tO\nspeaking\tO\nfrom\tO\nthe\tO\nnearby\tO\nvillage\tT-0\nof\tO\nAlkhan-Yurt\tB-LOC\n,\tO\nsaid\tO\nhe\tO\nhad\tO\nheard\tO\nlittle\tO\nfrom\tO\nGrozny\tO\nsince\tO\nWednesday\tO\nevening\tO\n's\tO\narrival\tO\nof\tO\nRussian\tO\nsecurity\tO\nchief\tO\nAlexander\tO\nLebed\tO\n,\tO\nwho\tO\nsaid\tO\nhe\tO\n\"\tO\ncame\tO\nwith\tO\npeace\tO\n\"\tO\n.\tO\n\nReuters\tO\ncorrespondent\tO\nLawrence\tO\nSheets\tO\n,\tO\nspeaking\tO\nfrom\tO\nthe\tO\nnearby\tO\nvillage\tO\nof\tO\nAlkhan-Yurt\tO\n,\tO\nsaid\tO\nhe\tO\nhad\tO\nheard\tO\nlittle\tO\nfrom\tT-0\nGrozny\tB-LOC\nsince\tO\nWednesday\tO\nevening\tO\n's\tO\narrival\tO\nof\tO\nRussian\tO\nsecurity\tO\nchief\tO\nAlexander\tO\nLebed\tO\n,\tO\nwho\tO\nsaid\tO\nhe\tO\n\"\tO\ncame\tT-1\nwith\tT-1\npeace\tT-1\n\"\tO\n.\tO\n\nReuters\tO\ncorrespondent\tO\nLawrence\tO\nSheets\tO\n,\tO\nspeaking\tO\nfrom\tO\nthe\tO\nnearby\tO\nvillage\tO\nof\tO\nAlkhan-Yurt\tO\n,\tO\nsaid\tO\nhe\tO\nhad\tO\nheard\tO\nlittle\tO\nfrom\tO\nGrozny\tO\nsince\tO\nWednesday\tO\nevening\tO\n's\tO\narrival\tT-0\nof\tT-1\nRussian\tB-MISC\nsecurity\tO\nchief\tO\nAlexander\tO\nLebed\tO\n,\tO\nwho\tO\nsaid\tO\nhe\tO\n\"\tO\ncame\tO\nwith\tO\npeace\tO\n\"\tO\n.\tO\n\nReuters\tO\ncorrespondent\tT-1\nLawrence\tO\nSheets\tO\n,\tO\nspeaking\tO\nfrom\tO\nthe\tO\nnearby\tO\nvillage\tO\nof\tO\nAlkhan-Yurt\tO\n,\tO\nsaid\tO\nhe\tO\nhad\tO\nheard\tO\nlittle\tO\nfrom\tO\nGrozny\tO\nsince\tO\nWednesday\tO\nevening\tO\n's\tO\narrival\tO\nof\tO\nRussian\tT-2\nsecurity\tT-2\nchief\tT-2\nAlexander\tB-PER\nLebed\tI-PER\n,\tO\nwho\tT-0\nsaid\tT-3\nhe\tO\n\"\tO\ncame\tO\nwith\tO\npeace\tO\n\"\tO\n.\tO\n\nLebed\tB-PER\nsaid\tO\non\tO\nWednesday\tO\nhe\tO\nhad\tO\nclinched\tT-0\na\tO\ntruce\tO\nwith\tO\nChechen\tT-1\nseparatists\tO\nand\tO\nhe\tO\npromised\tO\nto\tO\nhalt\tO\na\tO\nthreatened\tO\nbombing\tO\nassault\tO\non\tO\nGrozny\tT-2\n,\tO\nwhich\tO\nthe\tO\nrebels\tO\nhave\tO\nheld\tO\nsince\tO\nAugust\tO\n6\tO\n.\tO\n\nLebed\tT-0\nsaid\tO\non\tO\nWednesday\tO\nhe\tO\nhad\tO\nclinched\tO\na\tO\ntruce\tO\nwith\tO\nChechen\tB-MISC\nseparatists\tO\nand\tO\nhe\tO\npromised\tT-1\nto\tO\nhalt\tO\na\tO\nthreatened\tO\nbombing\tO\nassault\tO\non\tO\nGrozny\tO\n,\tO\nwhich\tO\nthe\tO\nrebels\tO\nhave\tO\nheld\tO\nsince\tO\nAugust\tO\n6\tO\n.\tO\n\nLebed\tT-0\nsaid\tO\non\tO\nWednesday\tO\nhe\tO\nhad\tO\nclinched\tO\na\tO\ntruce\tO\nwith\tO\nChechen\tO\nseparatists\tT-2\nand\tO\nhe\tO\npromised\tO\nto\tO\nhalt\tO\na\tO\nthreatened\tO\nbombing\tO\nassault\tT-1\non\tO\nGrozny\tB-LOC\n,\tO\nwhich\tO\nthe\tO\nrebels\tO\nhave\tO\nheld\tO\nsince\tO\nAugust\tO\n6\tO\n.\tO\n\nBoat\tT-1\npassengers\tT-1\nrescued\tT-2\noff\tO\nColombian\tB-MISC\ncoast\tT-0\n.\tO\n\nBOGOTA\tB-LOC\n,\tO\nColombia\tT-0\n1996-08-22\tO\n\nBOGOTA\tT-0\n,\tO\nColombia\tB-LOC\n1996-08-22\tO\n\nColombia\tB-LOC\n's\tO\nCoast\tO\nGuard\tO\non\tO\nThursday\tO\nrescued\tO\n12\tO\npeople\tO\nlost\tO\nfor\tO\nthree\tO\ndays\tO\nin\tO\nan\tO\nopen\tO\nboat\tO\noff\tT-0\nthe\tT-0\nPacific\tT-0\ncoast\tT-0\n,\tO\nofficials\tO\nsaid\tO\n.\tO\n\nColombia\tO\n's\tO\nCoast\tB-ORG\nGuard\tI-ORG\non\tO\nThursday\tO\nrescued\tO\n12\tO\npeople\tO\nlost\tO\nfor\tO\nthree\tO\ndays\tT-0\nin\tO\nan\tO\nopen\tO\nboat\tO\noff\tO\nthe\tO\nPacific\tT-1\ncoast\tT-1\n,\tO\nofficials\tO\nsaid\tO\n.\tO\n\nColombia\tT-0\n's\tO\nCoast\tO\nGuard\tO\non\tO\nThursday\tO\nrescued\tO\n12\tO\npeople\tO\nlost\tO\nfor\tO\nthree\tO\ndays\tO\nin\tO\nan\tO\nopen\tO\nboat\tO\noff\tO\nthe\tO\nPacific\tB-LOC\ncoast\tO\n,\tO\nofficials\tT-1\nsaid\tO\n.\tO\n\nThe\tO\nboat\tT-2\nhad\tO\nbeen\tO\nmissing\tO\nsince\tO\nMonday\tO\nafternoon\tO\nwhen\tO\nit\tO\nleft\tO\nthe\tO\ntiny\tO\nisland\tO\nof\tT-0\nGorgona\tB-LOC\noff\tT-1\nColombia\tO\n's\tO\nsouthwest\tO\ncoast\tO\nwith\tO\nsightseers\tO\nfor\tO\na\tO\nreturn\tO\ntrip\tO\nto\tO\nNarino\tO\nprovince\tO\n,\tO\nnear\tO\nthe\tO\nborder\tO\nwith\tO\nEcuador\tO\n.\tO\n\nThe\tO\nboat\tO\nhad\tO\nbeen\tO\nmissing\tO\nsince\tO\nMonday\tO\nafternoon\tO\nwhen\tO\nit\tO\nleft\tO\nthe\tO\ntiny\tO\nisland\tT-3\nof\tO\nGorgona\tT-0\noff\tO\nColombia\tB-LOC\n's\tO\nsouthwest\tT-4\ncoast\tT-4\nwith\tO\nsightseers\tO\nfor\tO\na\tO\nreturn\tO\ntrip\tO\nto\tO\nNarino\tT-1\nprovince\tO\n,\tO\nnear\tO\nthe\tO\nborder\tO\nwith\tO\nEcuador\tT-2\n.\tO\n\nThe\tO\nboat\tT-2\nhad\tO\nbeen\tO\nmissing\tT-0\nsince\tO\nMonday\tO\nafternoon\tO\nwhen\tO\nit\tO\nleft\tO\nthe\tO\ntiny\tO\nisland\tO\nof\tO\nGorgona\tO\noff\tO\nColombia\tT-3\n's\tO\nsouthwest\tO\ncoast\tO\nwith\tO\nsightseers\tO\nfor\tO\na\tO\nreturn\tO\ntrip\tT-1\nto\tO\nNarino\tB-LOC\nprovince\tT-4\n,\tO\nnear\tO\nthe\tO\nborder\tO\nwith\tO\nEcuador\tO\n.\tO\n\nThe\tO\nboat\tO\nhad\tO\nbeen\tO\nmissing\tO\nsince\tO\nMonday\tO\nafternoon\tO\nwhen\tO\nit\tO\nleft\tO\nthe\tO\ntiny\tO\nisland\tO\nof\tO\nGorgona\tO\noff\tO\nColombia\tT-1\n's\tO\nsouthwest\tO\ncoast\tO\nwith\tO\nsightseers\tO\nfor\tO\na\tO\nreturn\tO\ntrip\tO\nto\tO\nNarino\tT-2\nprovince\tT-2\n,\tO\nnear\tO\nthe\tO\nborder\tT-0\nwith\tT-3\nEcuador\tB-LOC\n.\tO\n\nThe\tO\nboat\tT-0\nran\tO\nout\tO\nof\tO\nfuel\tO\nand\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nradio\tT-1\nto\tO\ncall\tO\nfor\tO\nhelp\tO\n,\tO\nNavy\tB-ORG\nspokesman\tT-2\nLt.\tO\nItalo\tO\nPineda\tO\nsaid\tO\n.\tO\n\nThe\tO\nboat\tO\nran\tT-0\nout\tT-0\nof\tO\nfuel\tO\nand\tO\ndid\tO\nnot\tO\nhave\tO\na\tO\nradio\tO\nto\tO\ncall\tO\nfor\tO\nhelp\tO\n,\tO\nNavy\tO\nspokesman\tT-1\nLt.\tO\nItalo\tB-PER\nPineda\tI-PER\nsaid\tT-2\n.\tO\n\nThe\tO\nboat\tO\nwas\tO\ntowed\tO\nto\tO\nthe\tO\nport\tT-0\ncity\tT-1\nof\tT-1\nBuenaventura\tB-LOC\n.\tO\n\nArgentine\tB-MISC\nJuly\tO\nraw\tT-1\nsteel\tT-1\noutput\tT-0\nup\tO\n14.8\tO\npct\tO\nvs\tO\n'\tO\n95\tO\n.\tO\n\nArgentine\tB-MISC\nraw\tT-3\nsteel\tO\noutput\tO\nwas\tO\n355,900\tO\ntonnes\tO\nin\tO\nJuly\tO\n,\tO\n14.8\tO\npercent\tO\nhigher\tO\nthan\tO\nin\tO\nJuly\tO\n1995\tO\nand\tO\nup\tO\n1.9\tO\npercent\tO\nfrom\tO\nJune\tT-0\n,\tO\nSteel\tT-1\nIndustry\tT-1\nCenter\tT-1\nsaid\tO\nThursday\tO\n.\tT-2\n\n--\tO\nJason\tB-PER\nWebb\tI-PER\n,\tO\nBuenos\tT-0\nAires\tT-0\nNewsroom\tO\n+541\tO\n318-0655\tO\n\n--\tO\nJason\tT-0\nWebb\tT-0\n,\tO\nBuenos\tB-ORG\nAires\tI-ORG\nNewsroom\tI-ORG\n+541\tT-1\n318-0655\tT-1\n\nPeru\tB-LOC\n's\tO\nguerrillas\tT-0\nkill\tT-1\none\tO\n,\tO\ntake\tT-2\n8\tO\nhostage\tT-3\nin\tO\njungle\tT-4\n.\tO\n\nLIMA\tB-LOC\n,\tO\nPeru\tT-0\n1996-08-21\tO\n\nLIMA\tT-0\n,\tO\nPeru\tB-LOC\n1996-08-21\tO\n\nPeruvian\tB-MISC\nguerrillas\tT-1\nkilled\tT-0\none\tO\nman\tO\nand\tO\ntook\tO\neight\tO\npeople\tO\nhostage\tO\nafter\tO\ntaking\tO\nover\tO\na\tO\nvillage\tO\nin\tO\nthe\tO\ncountry\tO\n's\tO\nnortheastern\tO\njungle\tO\nregion\tO\n,\tO\nanti-\tO\nterrorist\tO\npolice\tO\nsources\tO\nsaid\tO\non\tO\nWednesday\tO\n.\tO\n\nFor\tO\nthree\tO\nhours\tO\non\tO\nTuesday\tO\n,\tO\naround\tO\n100\tO\nmembers\tO\nof\tO\nthe\tO\nMaoist\tB-MISC\nrebel\tT-0\ngroup\tO\nShining\tO\nPath\tO\ntook\tO\ncontrol\tT-1\nof\tO\nAlomella\tO\nRobles\tO\n,\tO\na\tO\nsmall\tO\nvillage\tO\nabout\tO\n345\tO\nmiles\tO\n(\tO\n550\tO\nkm\tO\n)\tO\nnortheast\tO\nof\tO\nLima\tO\n,\tO\nthe\tO\nsources\tO\nsaid\tO\n.\tO\n\nFor\tO\nthree\tO\nhours\tO\non\tO\nTuesday\tO\n,\tO\naround\tO\n100\tO\nmembers\tO\nof\tO\nthe\tO\nMaoist\tO\nrebel\tO\ngroup\tT-1\nShining\tB-ORG\nPath\tI-ORG\ntook\tO\ncontrol\tO\nof\tO\nAlomella\tT-0\nRobles\tT-0\n,\tO\na\tO\nsmall\tO\nvillage\tO\nabout\tO\n345\tO\nmiles\tO\n(\tO\n550\tO\nkm\tO\n)\tO\nnortheast\tO\nof\tO\nLima\tO\n,\tO\nthe\tO\nsources\tO\nsaid\tO\n.\tO\n\nFor\tO\nthree\tO\nhours\tO\non\tO\nTuesday\tO\n,\tO\naround\tO\n100\tO\nmembers\tO\nof\tO\nthe\tO\nMaoist\tT-0\nrebel\tT-0\ngroup\tT-0\nShining\tO\nPath\tO\ntook\tO\ncontrol\tO\nof\tO\nAlomella\tB-LOC\nRobles\tI-LOC\n,\tO\na\tO\nsmall\tO\nvillage\tO\nabout\tO\n345\tO\nmiles\tO\n(\tO\n550\tO\nkm\tO\n)\tO\nnortheast\tO\nof\tO\nLima\tO\n,\tO\nthe\tO\nsources\tO\nsaid\tO\n.\tO\n\nFor\tO\nthree\tO\nhours\tO\non\tO\nTuesday\tO\n,\tO\naround\tO\n100\tO\nmembers\tO\nof\tO\nthe\tO\nMaoist\tO\nrebel\tO\ngroup\tO\nShining\tO\nPath\tO\ntook\tO\ncontrol\tO\nof\tO\nAlomella\tO\nRobles\tO\n,\tO\na\tO\nsmall\tO\nvillage\tO\nabout\tO\n345\tO\nmiles\tO\n(\tO\n550\tO\nkm\tO\n)\tO\nnortheast\tT-0\nof\tO\nLima\tB-LOC\n,\tO\nthe\tO\nsources\tO\nsaid\tO\n.\tO\n\nIn\tO\nrecent\tO\nmonths\tO\nthe\tO\nShining\tB-ORG\nPath\tI-ORG\n,\tO\nseverely\tO\nweakened\tT-1\nsince\tO\nthe\tO\n1992\tO\ncapture\tO\nof\tO\nits\tT-0\nleader\tT-0\nAbimael\tO\nGuzman\tO\n,\tO\nhas\tO\nbeen\tO\nstepping\tO\nup\tO\nboth\tO\nits\tO\nmilitary\tO\nand\tO\npropaganda\tO\nactivities\tO\n.\tO\n\nIn\tO\nrecent\tO\nmonths\tO\nthe\tO\nShining\tT-0\nPath\tT-0\n,\tO\nseverely\tO\nweakened\tO\nsince\tO\nthe\tO\n1992\tT-2\ncapture\tT-2\nof\tO\nits\tO\nleader\tT-3\nAbimael\tB-PER\nGuzman\tI-PER\n,\tO\nhas\tT-1\nbeen\tT-1\nstepping\tT-1\nup\tT-1\nboth\tO\nits\tO\nmilitary\tO\nand\tO\npropaganda\tT-4\nactivities\tO\n.\tO\n\nPeru\tB-LOC\n's\tO\nguerrilla\tT-1\nconflicts\tO\nhave\tO\ncost\tO\nat\tO\nleast\tO\n30,000\tO\nlives\tO\nand\tO\n$\tO\n25\tO\nbillion\tO\nin\tO\ndamage\tO\nto\tO\ninfrastructure\tT-0\nsince\tO\n1980\tO\n.\tO\n\nFormer\tT-1\nSurinam\tB-LOC\nrebel\tO\nleader\tT-0\nheld\tO\nafter\tO\nshooting\tO\n.\tO\n\nPARAMARIBO\tO\n,\tO\nSurinam\tB-LOC\n1996-08-21\tT-0\n\nFlamboyant\tO\nformer\tT-0\nSurinamese\tB-MISC\nrebel\tO\nleader\tO\nRonny\tO\nBrunswijk\tO\nwas\tO\nin\tO\ncustody\tO\non\tO\nWednesday\tO\ncharged\tO\nwith\tO\nattempted\tO\nmurder\tO\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nFlamboyant\tT-0\nformer\tO\nSurinamese\tT-1\nrebel\tT-1\nleader\tT-2\nRonny\tB-PER\nBrunswijk\tI-PER\nwas\tO\nin\tO\ncustody\tO\non\tO\nWednesday\tO\ncharged\tO\nwith\tO\nattempted\tO\nmurder\tO\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nBrunswijk\tB-PER\nturned\tT-2\nhimself\tO\ninto\tO\npolice\tO\nafter\tO\nFreddy\tT-0\nPinas\tO\n,\tO\na\tO\nSurinamese-born\tO\nvisitor\tO\nfrom\tO\nthe\tO\nNetherlands\tO\n,\tO\naccused\tT-1\nBrunswijk\tO\nof\tO\ntrying\tO\nto\tO\nkill\tO\nhim\tO\non\tO\nSunday\tO\nafter\tO\na\tO\nbar-room\tO\nbrawl\tO\nin\tO\nthe\tO\nsmall\tO\nmining\tO\ntown\tO\nof\tO\nMoengo\tO\n,\tO\nabout\tO\n56\tO\nmiles\tO\n(\tO\n90\tO\nkm\tO\n)\tO\neast\tO\nof\tO\nParamaribo\tO\n,\tO\nsaid\tO\npolice\tO\nspokesman\tO\nRo\tO\nGajadhar\tO\n.\tO\n\nBrunswijk\tO\nturned\tT-1\nhimself\tT-1\ninto\tO\npolice\tT-2\nafter\tO\nFreddy\tB-PER\nPinas\tI-PER\n,\tO\na\tO\nSurinamese-born\tT-0\nvisitor\tT-0\nfrom\tO\nthe\tO\nNetherlands\tO\n,\tO\naccused\tO\nBrunswijk\tO\nof\tO\ntrying\tO\nto\tO\nkill\tO\nhim\tO\non\tO\nSunday\tO\nafter\tO\na\tO\nbar-room\tO\nbrawl\tO\nin\tO\nthe\tO\nsmall\tO\nmining\tO\ntown\tO\nof\tO\nMoengo\tO\n,\tO\nabout\tO\n56\tO\nmiles\tO\n(\tO\n90\tO\nkm\tO\n)\tO\neast\tO\nof\tO\nParamaribo\tO\n,\tO\nsaid\tO\npolice\tO\nspokesman\tO\nRo\tO\nGajadhar\tO\n.\tO\n\nBrunswijk\tO\nturned\tO\nhimself\tO\ninto\tO\npolice\tO\nafter\tO\nFreddy\tT-0\nPinas\tT-0\n,\tO\na\tO\nSurinamese-born\tB-MISC\nvisitor\tT-6\nfrom\tO\nthe\tO\nNetherlands\tT-5\n,\tO\naccused\tO\nBrunswijk\tT-1\nof\tO\ntrying\tO\nto\tO\nkill\tO\nhim\tO\non\tO\nSunday\tO\nafter\tO\na\tO\nbar-room\tO\nbrawl\tO\nin\tO\nthe\tO\nsmall\tO\nmining\tO\ntown\tO\nof\tO\nMoengo\tT-2\n,\tO\nabout\tO\n56\tO\nmiles\tO\n(\tO\n90\tO\nkm\tO\n)\tO\neast\tO\nof\tO\nParamaribo\tT-3\n,\tO\nsaid\tO\npolice\tO\nspokesman\tO\nRo\tT-4\nGajadhar\tT-4\n.\tO\n\nBrunswijk\tO\nturned\tO\nhimself\tO\ninto\tO\npolice\tO\nafter\tO\nFreddy\tO\nPinas\tO\n,\tO\na\tO\nSurinamese-born\tT-1\nvisitor\tO\nfrom\tT-4\nthe\tT-4\nNetherlands\tB-LOC\n,\tO\naccused\tO\nBrunswijk\tO\nof\tO\ntrying\tO\nto\tO\nkill\tT-0\nhim\tO\non\tO\nSunday\tO\nafter\tO\na\tO\nbar-room\tO\nbrawl\tO\nin\tO\nthe\tO\nsmall\tO\nmining\tO\ntown\tO\nof\tO\nMoengo\tT-2\n,\tO\nabout\tO\n56\tO\nmiles\tO\n(\tO\n90\tO\nkm\tO\n)\tO\neast\tO\nof\tO\nParamaribo\tT-3\n,\tO\nsaid\tO\npolice\tO\nspokesman\tO\nRo\tO\nGajadhar\tO\n.\tT-1\n\nBrunswijk\tO\nturned\tO\nhimself\tO\ninto\tO\npolice\tO\nafter\tO\nFreddy\tO\nPinas\tO\n,\tO\na\tO\nSurinamese-born\tT-3\nvisitor\tO\nfrom\tO\nthe\tO\nNetherlands\tO\n,\tO\naccused\tT-0\nBrunswijk\tB-PER\nof\tO\ntrying\tO\nto\tO\nkill\tT-1\nhim\tO\non\tO\nSunday\tO\nafter\tO\na\tO\nbar-room\tO\nbrawl\tO\nin\tO\nthe\tO\nsmall\tO\nmining\tO\ntown\tO\nof\tO\nMoengo\tT-2\n,\tO\nabout\tO\n56\tO\nmiles\tO\n(\tO\n90\tO\nkm\tO\n)\tO\neast\tO\nof\tO\nParamaribo\tO\n,\tO\nsaid\tO\npolice\tO\nspokesman\tO\nRo\tO\nGajadhar\tO\n.\tT-3\n\nBrunswijk\tO\nturned\tT-0\nhimself\tO\ninto\tO\npolice\tO\nafter\tO\nFreddy\tO\nPinas\tO\n,\tO\na\tO\nSurinamese-born\tO\nvisitor\tO\nfrom\tO\nthe\tO\nNetherlands\tO\n,\tO\naccused\tT-2\nBrunswijk\tO\nof\tO\ntrying\tO\nto\tO\nkill\tT-3\nhim\tO\non\tO\nSunday\tO\nafter\tO\na\tO\nbar-room\tO\nbrawl\tO\nin\tO\nthe\tO\nsmall\tO\nmining\tT-1\ntown\tT-5\nof\tT-5\nMoengo\tB-LOC\n,\tO\nabout\tO\n56\tO\nmiles\tO\n(\tO\n90\tO\nkm\tO\n)\tO\neast\tO\nof\tO\nParamaribo\tO\n,\tO\nsaid\tT-4\npolice\tO\nspokesman\tO\nRo\tO\nGajadhar\tO\n.\tO\n\nBrunswijk\tT-2\nturned\tO\nhimself\tO\ninto\tO\npolice\tO\nafter\tO\nFreddy\tT-7\nPinas\tT-7\n,\tO\na\tO\nSurinamese-born\tO\nvisitor\tO\nfrom\tO\nthe\tO\nNetherlands\tT-3\n,\tO\naccused\tT-9\nBrunswijk\tT-4\nof\tO\ntrying\tT-0\nto\tT-0\nkill\tT-0\nhim\tO\non\tO\nSunday\tO\nafter\tO\na\tO\nbar-room\tO\nbrawl\tT-1\nin\tO\nthe\tO\nsmall\tO\nmining\tO\ntown\tO\nof\tO\nMoengo\tT-5\n,\tO\nabout\tO\n56\tO\nmiles\tO\n(\tO\n90\tO\nkm\tO\n)\tO\neast\tT-8\nof\tO\nParamaribo\tB-LOC\n,\tO\nsaid\tO\npolice\tO\nspokesman\tO\nRo\tT-6\nGajadhar\tT-6\n.\tO\n\nBrunswijk\tT-1\nturned\tT-2\nhimself\tO\ninto\tO\npolice\tT-0\nafter\tO\nFreddy\tO\nPinas\tO\n,\tO\na\tO\nSurinamese-born\tO\nvisitor\tT-5\nfrom\tO\nthe\tO\nNetherlands\tO\n,\tO\naccused\tO\nBrunswijk\tO\nof\tO\ntrying\tO\nto\tO\nkill\tT-6\nhim\tO\non\tO\nSunday\tO\nafter\tO\na\tO\nbar-room\tO\nbrawl\tO\nin\tO\nthe\tO\nsmall\tO\nmining\tT-3\ntown\tO\nof\tO\nMoengo\tO\n,\tO\nabout\tO\n56\tO\nmiles\tO\n(\tO\n90\tO\nkm\tO\n)\tO\neast\tO\nof\tO\nParamaribo\tO\n,\tO\nsaid\tT-4\npolice\tO\nspokesman\tO\nRo\tB-PER\nGajadhar\tI-PER\n.\tO\n\nPinas\tB-PER\n,\tO\nshowing\tO\ncuts\tO\nand\tO\nbruises\tO\non\tO\nhis\tO\nface\tT-1\n,\tO\ntold\tO\nreporters\tO\nthe\tO\nformer\tO\nhead\tO\nof\tO\nthe\tO\nfeared\tO\nJungle\tT-0\nCommand\tO\nhad\tO\ntried\tO\nand\tO\nfailed\tO\nto\tO\nshoot\tO\nhim\tO\nafter\tO\nPinas\tO\nobjected\tO\nto\tO\nBrunswijk\tT-2\n's\tT-2\nadvances\tO\ntoward\tO\nhis\tO\nwife\tO\n.\tO\n\nPinas\tO\n,\tO\nshowing\tT-0\ncuts\tO\nand\tO\nbruises\tO\non\tO\nhis\tO\nface\tO\n,\tO\ntold\tO\nreporters\tO\nthe\tO\nformer\tO\nhead\tO\nof\tO\nthe\tO\nfeared\tT-1\nJungle\tB-ORG\nCommand\tI-ORG\nhad\tT-2\ntried\tO\nand\tO\nfailed\tO\nto\tO\nshoot\tO\nhim\tO\nafter\tO\nPinas\tO\nobjected\tO\nto\tO\nBrunswijk\tO\n's\tO\nadvances\tO\ntoward\tO\nhis\tO\nwife\tO\n.\tO\n\nPinas\tT-0\n,\tO\nshowing\tO\ncuts\tO\nand\tO\nbruises\tO\non\tO\nhis\tO\nface\tO\n,\tO\ntold\tO\nreporters\tO\nthe\tO\nformer\tO\nhead\tO\nof\tO\nthe\tO\nfeared\tO\nJungle\tT-2\nCommand\tT-2\nhad\tO\ntried\tO\nand\tO\nfailed\tO\nto\tO\nshoot\tO\nhim\tT-4\nafter\tO\nPinas\tB-PER\nobjected\tO\nto\tO\nBrunswijk\tT-3\n's\tT-1\nadvances\tO\ntoward\tO\nhis\tO\nwife\tO\n.\tO\n\nPinas\tO\n,\tO\nshowing\tO\ncuts\tT-0\nand\tO\nbruises\tO\non\tO\nhis\tO\nface\tO\n,\tO\ntold\tT-1\nreporters\tO\nthe\tO\nformer\tO\nhead\tO\nof\tO\nthe\tO\nfeared\tO\nJungle\tO\nCommand\tO\nhad\tO\ntried\tT-2\nand\tO\nfailed\tT-3\nto\tO\nshoot\tO\nhim\tO\nafter\tO\nPinas\tO\nobjected\tT-4\nto\tO\nBrunswijk\tB-PER\n's\tT-5\nadvances\tT-5\ntoward\tT-5\nhis\tT-5\nwife\tT-5\n.\tO\n\nPinas\tB-PER\nsaid\tT-0\nBrunswijk\tO\nthen\tO\nordered\tO\nhis\tO\nbodyguards\tO\nto\tO\nbeat\tO\nhim\tO\nup\tO\n.\tO\n\nPinas\tT-2\nsaid\tO\nBrunswijk\tB-PER\nthen\tO\nordered\tT-0\nhis\tO\nbodyguards\tT-3\nto\tO\nbeat\tT-1\nhim\tT-1\nup\tT-1\n.\tO\n\nBrunswijk\tB-PER\n,\tO\n35\tO\n,\tO\ndenied\tT-2\nthe\tO\ncharges\tT-0\nand\tO\nsaid\tT-3\nhe\tT-3\nhad\tO\nmerely\tO\ndefended\tO\nhimself\tO\nwhen\tO\nPinas\tT-1\nattacked\tO\nhim\tO\nwith\tO\na\tO\nbottle\tO\n.\tO\n\nBrunswijk\tO\n,\tO\n35\tO\n,\tO\ndenied\tT-0\nthe\tO\ncharges\tO\nand\tO\nsaid\tO\nhe\tO\nhad\tO\nmerely\tO\ndefended\tO\nhimself\tO\nwhen\tO\nPinas\tB-PER\nattacked\tT-1\nhim\tT-1\nwith\tT-1\na\tT-1\nbottle\tT-1\n.\tO\n\nIt\tO\nwas\tO\nthe\tT-2\nsecond\tT-2\ntime\tT-2\nBrunswijk\tB-PER\nhad\tT-1\nbeen\tT-1\ncharged\tT-3\nwith\tO\nattempted\tO\nmurder\tT-0\nin\tO\nless\tO\nthan\tO\ntwo\tO\nyears\tO\n.\tO\n\nBrunswijk\tB-PER\nled\tO\na\tO\nrebel\tO\ngroup\tO\nof\tO\nabout\tO\n1,000\tT-0\nin\tO\na\tO\n1986\tO\nuprising\tO\nagainst\tO\nthe\tO\nregime\tO\nof\tO\nmilitary\tO\nstrongman\tO\nDesi\tO\nBouterse\tO\n.\tT-0\n\nBrunswijk\tO\nled\tO\na\tO\nrebel\tO\ngroup\tO\nof\tO\nabout\tO\n1,000\tO\nin\tO\na\tO\n1986\tT-1\nuprising\tT-1\nagainst\tO\nthe\tO\nregime\tT-0\nof\tO\nmilitary\tO\nstrongman\tO\nDesi\tB-PER\nBouterse\tI-PER\n.\tO\n\nThe\tO\nconflict\tO\n,\tO\nwhich\tO\nkilled\tO\nmore\tO\nthan\tO\n500\tO\nand\tO\ncaused\tO\nthousands\tO\nto\tO\nflee\tO\nto\tO\nneighbouring\tT-0\nFrench\tB-LOC\nGuiana\tI-LOC\nin\tO\nthe\tO\nlate\tO\n1980s\tO\n,\tO\neventually\tO\npaved\tT-1\nthe\tO\nway\tO\nto\tO\ndemocratic\tO\nelections\tO\nin\tO\n1991\tO\n.\tO\n\nDespite\tO\nnumerous\tT-2\nproblems\tT-2\nwith\tO\nauthorities\tT-0\n,\tO\nBrunswijk\tB-PER\nwent\tT-1\non\tO\nto\tO\nbecome\tO\na\tO\nsuccessful\tO\nbusinessman\tO\nwith\tO\nmining\tO\nand\tO\nlogging\tO\ninterests\tO\n.\tO\n\nNoisy\tT-0\nsaw\tO\nleads\tT-2\nThai\tB-MISC\npolice\tT-1\nto\tO\nheroin\tO\nhideaway\tO\n.\tO\n\nA\tT-0\nHong\tB-LOC\nKong\tI-LOC\ncarpenter\tO\nwas\tO\narrested\tT-1\nin\tO\nthe\tO\nThai\tT-2\nseaside\tT-2\ntown\tT-2\nof\tT-2\nPattaya\tT-2\nafter\tO\npolice\tO\nseized\tO\n18\tO\nkg\tO\n(\tO\n39.7\tO\npounds\tO\n)\tO\nof\tO\nheroin\tO\nfollowing\tO\ncomplaints\tO\nby\tO\nresidents\tO\nof\tO\na\tO\nnoisy\tO\nsaw\tO\n,\tO\npolice\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nA\tO\nHong\tO\nKong\tO\ncarpenter\tO\nwas\tO\narrested\tO\nin\tO\nthe\tO\nThai\tB-MISC\nseaside\tT-0\ntown\tO\nof\tO\nPattaya\tO\nafter\tO\npolice\tO\nseized\tO\n18\tO\nkg\tO\n(\tO\n39.7\tO\npounds\tO\n)\tO\nof\tO\nheroin\tO\nfollowing\tT-1\ncomplaints\tT-2\nby\tO\nresidents\tO\nof\tO\na\tO\nnoisy\tO\nsaw\tO\n,\tO\npolice\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nA\tO\nHong\tO\nKong\tO\ncarpenter\tO\nwas\tO\narrested\tT-0\nin\tO\nthe\tO\nThai\tO\nseaside\tT-1\ntown\tT-2\nof\tT-2\nPattaya\tB-LOC\nafter\tO\npolice\tO\nseized\tO\n18\tO\nkg\tO\n(\tO\n39.7\tO\npounds\tO\n)\tO\nof\tO\nheroin\tO\nfollowing\tO\ncomplaints\tO\nby\tO\nresidents\tO\nof\tO\na\tO\nnoisy\tO\nsaw\tO\n,\tO\npolice\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nCheung\tB-PER\nSiu\tI-PER\nMan\tI-PER\n,\tO\n40\tT-1\n,\tO\nwas\tO\narrested\tT-0\nlate\tO\non\tO\nWednesday\tO\nafter\tO\npolice\tO\nsearched\tO\na\tO\nhouse\tO\nand\tO\nfound\tO\nheroin\tO\nin\tO\nbags\tO\nand\tO\nhidden\tO\nin\tO\nhollow\tO\nspaces\tO\nin\tO\nwooden\tO\nplanks\tO\n,\tO\npolice\tO\nsaid\tO\n.\tO\n\nCheung\tB-PER\nwas\tO\nbeing\tO\ndetained\tT-1\npending\tO\nformal\tO\ncharges\tO\n,\tO\npolice\tO\nsaid\tT-0\n.\tO\n\nAustralia\tB-LOC\nforeign\tT-0\nminister\tO\narrives\tO\nin\tO\nChina\tO\n.\tO\n\nAustralia\tO\nforeign\tT-0\nminister\tT-0\narrives\tO\nin\tT-1\nChina\tB-LOC\n.\tO\n\nAustralian\tB-MISC\nForeign\tT-1\nMinister\tT-1\nAlexander\tO\nDowner\tT-0\narrived\tO\nin\tO\nBeijing\tO\non\tO\nThursday\tO\nfor\tO\na\tO\nfour-day\tO\nvisit\tO\nthat\tO\nfollows\tO\nrising\tO\nfriction\tO\nbetween\tO\nthe\tT-2\ntwo\tT-2\nnations\tT-2\nin\tO\nrecent\tO\nweeks\tO\n.\tT-0\n\nAustralian\tT-0\nForeign\tT-0\nMinister\tT-0\nAlexander\tB-PER\nDowner\tI-PER\narrived\tT-1\nin\tO\nBeijing\tO\non\tO\nThursday\tO\nfor\tO\na\tO\nfour-day\tO\nvisit\tO\nthat\tO\nfollows\tO\nrising\tO\nfriction\tO\nbetween\tO\nthe\tO\ntwo\tO\nnations\tO\nin\tO\nrecent\tO\nweeks\tO\n.\tO\n\nAustralian\tO\nForeign\tO\nMinister\tO\nAlexander\tT-3\nDowner\tT-3\narrived\tT-0\nin\tO\nBeijing\tB-LOC\non\tO\nThursday\tO\nfor\tO\na\tO\nfour-day\tO\nvisit\tT-1\nthat\tO\nfollows\tO\nrising\tT-2\nfriction\tO\nbetween\tO\nthe\tO\ntwo\tO\nnations\tO\nin\tO\nrecent\tO\nweeks\tO\n.\tO\n\nDowner\tB-PER\nwas\tO\nto\tO\nmeet\tT-0\nChinese\tO\nForeign\tO\nMinister\tO\nQian\tT-4\nQichen\tT-4\nand\tO\nsign\tO\nan\tO\nagreement\tT-1\non\tO\nan\tO\nAustralian\tO\nconsulate\tO\nin\tO\nHong\tO\nKong\tO\n,\tO\nan\tO\nofficial\tO\nof\tO\nthe\tO\nAustralian\tT-3\nembassy\tT-3\nin\tO\nBeijing\tO\nsaid\tT-2\n.\tO\n\nDowner\tT-2\nwas\tO\nto\tO\nmeet\tT-0\nChinese\tB-MISC\nForeign\tT-1\nMinister\tT-1\nQian\tO\nQichen\tO\nand\tO\nsign\tO\nan\tO\nagreement\tO\non\tO\nan\tO\nAustralian\tO\nconsulate\tO\nin\tO\nHong\tO\nKong\tO\n,\tO\nan\tO\nofficial\tO\nof\tO\nthe\tO\nAustralian\tO\nembassy\tO\nin\tO\nBeijing\tO\nsaid\tO\n.\tO\n\nDowner\tO\nwas\tO\nto\tO\nmeet\tO\nChinese\tO\nForeign\tO\nMinister\tO\nQian\tB-PER\nQichen\tI-PER\nand\tO\nsign\tO\nan\tO\nagreement\tO\non\tO\nan\tO\nAustralian\tT-3\nconsulate\tT-0\nin\tO\nHong\tT-2\nKong\tT-2\n,\tO\nan\tO\nofficial\tO\nof\tO\nthe\tO\nAustralian\tO\nembassy\tO\nin\tO\nBeijing\tO\nsaid\tT-1\n.\tO\n\nDowner\tO\nwas\tO\nto\tO\nmeet\tO\nChinese\tO\nForeign\tO\nMinister\tO\nQian\tO\nQichen\tO\nand\tO\nsign\tT-1\nan\tT-1\nagreement\tT-1\non\tT-1\nan\tO\nAustralian\tB-MISC\nconsulate\tT-0\nin\tO\nHong\tO\nKong\tO\n,\tO\nan\tO\nofficial\tO\nof\tO\nthe\tO\nAustralian\tO\nembassy\tO\nin\tO\nBeijing\tO\nsaid\tO\n.\tO\n\nDowner\tO\nwas\tO\nto\tO\nmeet\tT-0\nChinese\tT-4\nForeign\tT-4\nMinister\tT-4\nQian\tT-4\nQichen\tT-4\nand\tO\nsign\tT-1\nan\tO\nagreement\tO\non\tO\nan\tO\nAustralian\tT-5\nconsulate\tT-5\nin\tO\nHong\tB-LOC\nKong\tI-LOC\n,\tO\nan\tO\nofficial\tO\nof\tO\nthe\tO\nAustralian\tO\nembassy\tO\nin\tO\nBeijing\tT-3\nsaid\tT-2\n.\tO\n\nDowner\tO\nwas\tO\nto\tO\nmeet\tO\nChinese\tO\nForeign\tO\nMinister\tO\nQian\tO\nQichen\tT-1\nand\tO\nsign\tO\nan\tO\nagreement\tO\non\tO\nan\tO\nAustralian\tT-3\nconsulate\tT-3\nin\tO\nHong\tO\nKong\tO\n,\tO\nan\tO\nofficial\tO\nof\tO\nthe\tT-0\nAustralian\tB-MISC\nembassy\tT-4\nin\tO\nBeijing\tO\nsaid\tT-2\n.\tO\n\nDowner\tO\nwas\tO\nto\tO\nmeet\tO\nChinese\tO\nForeign\tO\nMinister\tO\nQian\tO\nQichen\tO\nand\tO\nsign\tO\nan\tO\nagreement\tO\non\tO\nan\tO\nAustralian\tO\nconsulate\tO\nin\tO\nHong\tO\nKong\tO\n,\tO\nan\tO\nofficial\tO\nof\tO\nthe\tO\nAustralian\tO\nembassy\tT-0\nin\tO\nBeijing\tB-LOC\nsaid\tT-1\n.\tO\n\nChina\tB-LOC\nwill\tO\nresume\tO\nsovereignty\tO\nover\tO\nHong\tT-0\nKong\tT-0\n,\tO\na\tO\nBritish\tT-1\ncolony\tT-1\n,\tO\nin\tO\nmid-1997\tO\n.\tO\n\nChina\tO\nwill\tO\nresume\tT-1\nsovereignty\tT-1\nover\tO\nHong\tB-LOC\nKong\tI-LOC\n,\tO\na\tO\nBritish\tT-2\ncolony\tT-2\n,\tO\nin\tO\nmid-1997\tO\n.\tO\n\nChina\tO\nwill\tO\nresume\tO\nsovereignty\tT-2\nover\tT-0\nHong\tO\nKong\tO\n,\tO\na\tO\nBritish\tB-MISC\ncolony\tT-1\n,\tO\nin\tO\nmid-1997\tT-3\n.\tO\n\nRelations\tO\nbetween\tO\nChina\tB-LOC\nand\tO\nAustralia\tO\nhave\tO\nbeen\tO\nstrained\tT-0\nin\tO\nrecent\tO\nweeks\tO\nbecause\tO\nof\tO\nAustralia\tO\n's\tO\nplan\tO\nto\tO\nsell\tO\nuranium\tT-1\nto\tO\nChina\tO\n's\tO\nrival\tO\nTaiwan\tO\n.\tO\n\nRelations\tT-0\nbetween\tT-0\nChina\tT-0\nand\tT-0\nAustralia\tB-LOC\nhave\tO\nbeen\tO\nstrained\tO\nin\tO\nrecent\tT-1\nweeks\tO\nbecause\tO\nof\tO\nAustralia\tO\n's\tO\nplan\tO\nto\tO\nsell\tO\nuranium\tO\nto\tO\nChina\tO\n's\tO\nrival\tO\nTaiwan\tO\n.\tO\n\nRelations\tT-3\nbetween\tO\nChina\tT-4\nand\tO\nAustralia\tT-5\nhave\tO\nbeen\tO\nstrained\tO\nin\tO\nrecent\tO\nweeks\tO\nbecause\tT-0\nof\tT-0\nAustralia\tB-LOC\n's\tT-2\nplan\tT-2\nto\tT-1\nsell\tT-1\nuranium\tT-1\nto\tO\nChina\tO\n's\tO\nrival\tO\nTaiwan\tO\n.\tO\n\nRelations\tO\nbetween\tO\nChina\tT-2\nand\tO\nAustralia\tT-3\nhave\tO\nbeen\tO\nstrained\tO\nin\tO\nrecent\tO\nweeks\tO\nbecause\tO\nof\tO\nAustralia\tO\n's\tO\nplan\tO\nto\tO\nsell\tO\nuranium\tT-0\nto\tT-1\nChina\tB-LOC\n's\tO\nrival\tO\nTaiwan\tO\n.\tO\n\nRelations\tO\nbetween\tO\nChina\tO\nand\tO\nAustralia\tO\nhave\tO\nbeen\tO\nstrained\tO\nin\tO\nrecent\tO\nweeks\tO\nbecause\tO\nof\tO\nAustralia\tO\n's\tO\nplan\tO\nto\tO\nsell\tO\nuranium\tT-0\nto\tO\nChina\tT-2\n's\tT-2\nrival\tT-2\nTaiwan\tB-LOC\n.\tO\n\nOther\tO\nissues\tO\naffecting\tO\nties\tO\ninclude\tO\nplans\tO\nby\tT-0\nan\tT-0\nAustralian\tB-MISC\ncabinet\tO\nminister\tO\nto\tO\nvisit\tO\nTaiwan\tO\n,\tO\na\tO\nsecurity\tO\npact\tO\nbetween\tO\nCanberra\tO\nand\tO\nWashington\tO\nand\tO\na\tO\npossible\tO\nvisit\tO\nto\tO\nAustralia\tO\nnext\tO\nmonth\tO\nby\tO\nTibet\tO\n's\tO\nexiled\tO\nspiritual\tO\nleader\tO\nthe\tO\nDalai\tO\nLama\tO\n.\tO\n\nOther\tO\nissues\tO\naffecting\tO\nties\tO\ninclude\tO\nplans\tO\nby\tO\nan\tO\nAustralian\tT-1\ncabinet\tT-1\nminister\tO\nto\tO\nvisit\tO\nTaiwan\tB-LOC\n,\tO\na\tO\nsecurity\tO\npact\tT-2\nbetween\tO\nCanberra\tT-0\nand\tO\nWashington\tT-3\nand\tO\na\tO\npossible\tO\nvisit\tO\nto\tO\nAustralia\tO\nnext\tO\nmonth\tO\nby\tO\nTibet\tO\n's\tO\nexiled\tO\nspiritual\tO\nleader\tO\nthe\tO\nDalai\tO\nLama\tO\n.\tO\n\nOther\tO\nissues\tT-1\naffecting\tO\nties\tO\ninclude\tO\nplans\tO\nby\tO\nan\tO\nAustralian\tO\ncabinet\tO\nminister\tO\nto\tO\nvisit\tO\nTaiwan\tT-2\n,\tO\na\tO\nsecurity\tO\npact\tO\nbetween\tO\nCanberra\tB-LOC\nand\tT-0\nWashington\tT-3\nand\tO\na\tO\npossible\tO\nvisit\tO\nto\tO\nAustralia\tO\nnext\tO\nmonth\tO\nby\tO\nTibet\tO\n's\tO\nexiled\tO\nspiritual\tO\nleader\tO\nthe\tO\nDalai\tO\nLama\tO\n.\tO\n\nOther\tO\nissues\tT-3\naffecting\tO\nties\tO\ninclude\tO\nplans\tO\nby\tO\nan\tO\nAustralian\tT-0\ncabinet\tT-0\nminister\tT-0\nto\tO\nvisit\tT-4\nTaiwan\tT-1\n,\tO\na\tO\nsecurity\tO\npact\tO\nbetween\tO\nCanberra\tT-5\nand\tO\nWashington\tB-LOC\nand\tO\na\tO\npossible\tO\nvisit\tO\nto\tO\nAustralia\tO\nnext\tT-2\nmonth\tT-2\nby\tO\nTibet\tO\n's\tO\nexiled\tO\nspiritual\tO\nleader\tO\nthe\tO\nDalai\tO\nLama\tO\n.\tO\n\nOther\tO\nissues\tO\naffecting\tO\nties\tO\ninclude\tO\nplans\tO\nby\tO\nan\tO\nAustralian\tO\ncabinet\tT-2\nminister\tT-2\nto\tO\nvisit\tO\nTaiwan\tO\n,\tO\na\tO\nsecurity\tO\npact\tO\nbetween\tO\nCanberra\tO\nand\tO\nWashington\tO\nand\tO\na\tO\npossible\tT-0\nvisit\tO\nto\tO\nAustralia\tB-LOC\nnext\tO\nmonth\tO\nby\tO\nTibet\tO\n's\tO\nexiled\tT-1\nspiritual\tO\nleader\tO\nthe\tO\nDalai\tO\nLama\tO\n.\tO\n\nOther\tO\nissues\tO\naffecting\tO\nties\tO\ninclude\tO\nplans\tO\nby\tO\nan\tO\nAustralian\tO\ncabinet\tT-0\nminister\tT-0\nto\tO\nvisit\tT-1\nTaiwan\tO\n,\tO\na\tO\nsecurity\tT-2\npact\tT-2\nbetween\tO\nCanberra\tO\nand\tO\nWashington\tO\nand\tO\na\tO\npossible\tO\nvisit\tO\nto\tO\nAustralia\tO\nnext\tO\nmonth\tO\nby\tT-3\nTibet\tB-LOC\n's\tO\nexiled\tO\nspiritual\tO\nleader\tO\nthe\tO\nDalai\tO\nLama\tO\n.\tO\n\nOther\tO\nissues\tO\naffecting\tO\nties\tO\ninclude\tO\nplans\tO\nby\tO\nan\tO\nAustralian\tO\ncabinet\tO\nminister\tO\nto\tO\nvisit\tO\nTaiwan\tO\n,\tO\na\tO\nsecurity\tO\npact\tO\nbetween\tO\nCanberra\tO\nand\tO\nWashington\tO\nand\tO\na\tO\npossible\tO\nvisit\tO\nto\tO\nAustralia\tO\nnext\tO\nmonth\tO\nby\tO\nTibet\tO\n's\tO\nexiled\tO\nspiritual\tO\nleader\tT-0\nthe\tO\nDalai\tB-PER\nLama\tI-PER\n.\tO\n\nDowner\tB-PER\nis\tO\nthe\tO\nfirst\tO\nAustralian\tT-3\nminister\tT-3\nto\tO\nvisit\tO\nChina\tT-1\nsince\tO\nthe\tO\nnew\tO\nconservative\tO\ngovernment\tO\ntook\tO\noffice\tO\nin\tO\nCanberra\tT-2\nin\tO\nMarch\tO\n.\tO\n\nDowner\tT-0\nis\tO\nthe\tO\nfirst\tO\nAustralian\tB-MISC\nminister\tT-2\nto\tO\nvisit\tT-1\nChina\tT-1\nsince\tO\nthe\tO\nnew\tO\nconservative\tO\ngovernment\tO\ntook\tO\noffice\tO\nin\tO\nCanberra\tO\nin\tO\nMarch\tO\n.\tO\n\nDowner\tO\nis\tO\nthe\tO\nfirst\tO\nAustralian\tO\nminister\tT-2\nto\tO\nvisit\tT-1\nChina\tB-LOC\nsince\tO\nthe\tO\nnew\tO\nconservative\tO\ngovernment\tO\ntook\tT-0\noffice\tO\nin\tO\nCanberra\tO\nin\tO\nMarch\tO\n.\tO\n\nDowner\tO\nis\tO\nthe\tO\nfirst\tT-1\nAustralian\tT-0\nminister\tO\nto\tO\nvisit\tT-2\nChina\tO\nsince\tO\nthe\tO\nnew\tO\nconservative\tO\ngovernment\tO\ntook\tO\noffice\tO\nin\tO\nCanberra\tB-LOC\nin\tO\nMarch\tO\n.\tO\n\nPalestinians\tB-MISC\naccuse\tT-1\nPA\tT-0\nof\tO\nbanning\tO\nbooks\tO\n.\tO\n\nPalestinians\tT-1\naccuse\tT-0\nPA\tB-ORG\nof\tO\nbanning\tO\nbooks\tO\n.\tO\n\nNABLUS\tT-0\n,\tO\nWest\tB-LOC\nBank\tI-LOC\n1996-08-22\tO\n\nA\tT-0\nWest\tB-LOC\nBank\tI-LOC\nbookseller\tT-1\ncharged\tO\non\tO\nThursday\tO\nthat\tO\nthe\tO\nPalestinian\tO\nInformation\tO\nMinistry\tO\nhas\tO\nforced\tO\nhim\tO\nto\tO\nsign\tO\nan\tO\nundertaking\tO\nnot\tO\nto\tO\ndistribute\tO\nbooks\tO\nwritten\tO\nby\tO\ncritics\tO\nof\tO\nIsraeli-PLO\tT-2\nself-rule\tO\ndeals\tO\n.\tO\n\nA\tO\nWest\tO\nBank\tO\nbookseller\tO\ncharged\tO\non\tO\nThursday\tO\nthat\tO\nthe\tO\nPalestinian\tB-ORG\nInformation\tI-ORG\nMinistry\tI-ORG\nhas\tO\nforced\tO\nhim\tO\nto\tO\nsign\tO\nan\tO\nundertaking\tT-0\nnot\tO\nto\tO\ndistribute\tO\nbooks\tO\nwritten\tO\nby\tO\ncritics\tO\nof\tO\nIsraeli-PLO\tO\nself-rule\tO\ndeals\tO\n.\tO\n\nA\tO\nWest\tO\nBank\tO\nbookseller\tO\ncharged\tO\non\tO\nThursday\tO\nthat\tO\nthe\tO\nPalestinian\tO\nInformation\tO\nMinistry\tO\nhas\tO\nforced\tO\nhim\tO\nto\tO\nsign\tO\nan\tO\nundertaking\tO\nnot\tO\nto\tO\ndistribute\tO\nbooks\tO\nwritten\tO\nby\tO\ncritics\tT-1\nof\tO\nIsraeli-PLO\tB-MISC\nself-rule\tT-0\ndeals\tT-0\n.\tO\n\nOne\tO\nofficial\tT-1\ntold\tO\nme\tO\n'\tO\nyou\tO\nhave\tO\nto\tO\neither\tO\ndestroy\tO\nthe\tO\nbooks\tO\nor\tO\nreturn\tT-2\nthem\tO\nto\tO\nAmman\tB-LOC\n'\tO\n,\tO\n\"\tO\nDaoud\tO\nMakkawi\tO\n,\tO\nowner\tT-0\nof\tO\nthe\tO\nNablus-based\tO\nal-Risala\tO\nbookshop\tO\n,\tO\ntold\tO\nReuters\tO\n.\tO\n\nOne\tO\nofficial\tO\ntold\tO\nme\tO\n'\tO\nyou\tO\nhave\tO\nto\tO\neither\tO\ndestroy\tT-2\nthe\tO\nbooks\tO\nor\tO\nreturn\tO\nthem\tO\nto\tO\nAmman\tO\n'\tO\n,\tO\n\"\tO\nDaoud\tB-PER\nMakkawi\tI-PER\n,\tO\nowner\tT-0\nof\tO\nthe\tO\nNablus-based\tO\nal-Risala\tT-1\nbookshop\tT-1\n,\tO\ntold\tO\nReuters\tO\n.\tO\n\nOne\tO\nofficial\tO\ntold\tT-0\nme\tO\n'\tO\nyou\tO\nhave\tO\nto\tO\neither\tO\ndestroy\tO\nthe\tO\nbooks\tO\nor\tO\nreturn\tO\nthem\tO\nto\tO\nAmman\tO\n'\tO\n,\tO\n\"\tO\nDaoud\tT-1\nMakkawi\tT-1\n,\tO\nowner\tT-2\nof\tT-2\nthe\tT-2\nNablus-based\tB-MISC\nal-Risala\tT-2\nbookshop\tT-2\n,\tO\ntold\tO\nReuters\tO\n.\tO\n\nOne\tO\nofficial\tO\ntold\tO\nme\tO\n'\tO\nyou\tO\nhave\tO\nto\tO\neither\tO\ndestroy\tO\nthe\tO\nbooks\tO\nor\tO\nreturn\tO\nthem\tO\nto\tO\nAmman\tT-0\n'\tO\n,\tO\n\"\tO\nDaoud\tO\nMakkawi\tO\n,\tO\nowner\tO\nof\tO\nthe\tO\nNablus-based\tO\nal-Risala\tB-LOC\nbookshop\tT-1\n,\tO\ntold\tO\nReuters\tO\n.\tO\n\nOne\tO\nofficial\tO\ntold\tT-3\nme\tO\n'\tO\nyou\tO\nhave\tO\nto\tO\neither\tO\ndestroy\tT-0\nthe\tO\nbooks\tO\nor\tO\nreturn\tT-1\nthem\tO\nto\tO\nAmman\tO\n'\tO\n,\tO\n\"\tO\nDaoud\tO\nMakkawi\tO\n,\tO\nowner\tO\nof\tO\nthe\tO\nNablus-based\tO\nal-Risala\tO\nbookshop\tO\n,\tO\ntold\tT-2\nReuters\tB-ORG\n.\tO\n\nHe\tO\nsaid\tT-5\nministry\tT-2\nofficials\tT-2\nmade\tO\nhim\tO\nsign\tO\nthis\tO\na\tO\nfew\tO\nweeks\tO\nago\tO\nafter\tO\nhe\tO\nbrought\tT-0\nabout\tO\na\tO\ndozen\tO\ncopies\tO\nfrom\tT-1\nJordan\tB-LOC\nof\tO\na\tO\nbook\tO\nby\tO\nEdward\tO\nSaid\tT-6\n,\tO\na\tO\nprominent\tO\nscholar\tO\nat\tO\nNew\tT-3\nYork\tT-3\nCity\tT-3\n's\tO\nColumbia\tT-4\nUniversity\tT-4\n.\tO\n\nHe\tT-0\nsaid\tT-0\nministry\tO\nofficials\tO\nmade\tO\nhim\tO\nsign\tO\nthis\tO\na\tO\nfew\tO\nweeks\tO\nago\tO\nafter\tO\nhe\tO\nbrought\tO\nabout\tO\na\tO\ndozen\tT-1\ncopies\tT-1\nfrom\tO\nJordan\tO\nof\tO\na\tO\nbook\tT-3\nby\tO\nEdward\tB-PER\nSaid\tI-PER\n,\tO\na\tO\nprominent\tT-2\nscholar\tT-2\nat\tO\nNew\tO\nYork\tO\nCity\tO\n's\tO\nColumbia\tO\nUniversity\tO\n.\tO\n\nHe\tO\nsaid\tO\nministry\tO\nofficials\tO\nmade\tO\nhim\tO\nsign\tO\nthis\tO\na\tO\nfew\tO\nweeks\tO\nago\tO\nafter\tO\nhe\tO\nbrought\tO\nabout\tO\na\tO\ndozen\tT-0\ncopies\tO\nfrom\tO\nJordan\tT-1\nof\tO\na\tO\nbook\tO\nby\tO\nEdward\tT-2\nSaid\tO\n,\tO\na\tO\nprominent\tO\nscholar\tO\nat\tT-3\nNew\tB-LOC\nYork\tI-LOC\nCity\tI-LOC\n's\tO\nColumbia\tO\nUniversity\tO\n.\tO\n\nHe\tO\nsaid\tO\nministry\tT-0\nofficials\tO\nmade\tO\nhim\tO\nsign\tO\nthis\tO\na\tO\nfew\tO\nweeks\tO\nago\tO\nafter\tO\nhe\tO\nbrought\tO\nabout\tO\na\tO\ndozen\tO\ncopies\tO\nfrom\tO\nJordan\tO\nof\tO\na\tO\nbook\tO\nby\tO\nEdward\tO\nSaid\tT-2\n,\tO\na\tO\nprominent\tO\nscholar\tT-1\nat\tO\nNew\tT-3\nYork\tT-3\nCity\tT-3\n's\tT-3\nColumbia\tB-ORG\nUniversity\tI-ORG\n.\tO\n\nSaid\tB-PER\n,\tO\na\tT-1\nU.S.\tT-1\ncitizen\tT-1\nof\tO\nPalestinian\tT-0\norigin\tO\n,\tO\nhas\tO\nbeen\tO\nan\tO\noutspoken\tO\ncritic\tO\nof\tO\nthe\tO\n1993\tO\nIsraeli-PLO\tO\nself-rule\tO\ndeal\tO\nand\tO\nhas\tO\nwritten\tO\nat\tO\nleast\tO\ntwo\tO\nbooks\tO\non\tO\nthe\tO\naccord\tO\n.\tO\n\nSaid\tO\n,\tO\na\tO\nU.S.\tB-LOC\ncitizen\tO\nof\tO\nPalestinian\tT-0\norigin\tO\n,\tO\nhas\tO\nbeen\tO\nan\tO\noutspoken\tO\ncritic\tO\nof\tO\nthe\tO\n1993\tO\nIsraeli-PLO\tT-1\nself-rule\tO\ndeal\tO\nand\tO\nhas\tO\nwritten\tO\nat\tO\nleast\tO\ntwo\tO\nbooks\tO\non\tO\nthe\tO\naccord\tO\n.\tO\n\nSaid\tO\n,\tO\na\tT-2\nU.S.\tT-2\ncitizen\tT-2\nof\tO\nPalestinian\tB-MISC\norigin\tO\n,\tO\nhas\tO\nbeen\tO\nan\tO\noutspoken\tT-0\ncritic\tT-3\nof\tO\nthe\tO\n1993\tO\nIsraeli-PLO\tO\nself-rule\tT-1\ndeal\tO\nand\tO\nhas\tO\nwritten\tT-4\nat\tO\nleast\tO\ntwo\tO\nbooks\tO\non\tO\nthe\tO\naccord\tO\n.\tO\n\nSaid\tO\n,\tO\na\tO\nU.S.\tO\ncitizen\tO\nof\tO\nPalestinian\tT-0\norigin\tO\n,\tO\nhas\tO\nbeen\tO\nan\tO\noutspoken\tO\ncritic\tO\nof\tO\nthe\tO\n1993\tO\nIsraeli-PLO\tB-MISC\nself-rule\tO\ndeal\tO\nand\tO\nhas\tO\nwritten\tO\nat\tO\nleast\tO\ntwo\tO\nbooks\tO\non\tO\nthe\tO\naccord\tO\n.\tO\n\nOn\tO\nWednesday\tO\na\tO\nbookseller\tT-2\nin\tO\nthe\tO\nWest\tB-LOC\nBank\tI-LOC\ntown\tT-0\nof\tO\nRamallah\tT-5\nsaid\tT-1\npolice\tO\nabout\tO\na\tO\nmonth\tO\nago\tO\nconfiscated\tT-3\nseveral\tO\ncopies\tO\nof\tO\ntwo\tO\nof\tO\nSaid\tT-4\n's\tO\nbooks\tO\non\tO\nthe\tO\nIsrael-PLO\tT-6\nself-rule\tO\ndeals\tO\n.\tO\n\nOn\tO\nWednesday\tT-0\na\tO\nbookseller\tO\nin\tO\nthe\tO\nWest\tO\nBank\tO\ntown\tT-1\nof\tT-1\nRamallah\tB-LOC\nsaid\tT-2\npolice\tO\nabout\tO\na\tO\nmonth\tO\nago\tO\nconfiscated\tO\nseveral\tO\ncopies\tO\nof\tO\ntwo\tO\nof\tO\nSaid\tO\n's\tO\nbooks\tO\non\tO\nthe\tO\nIsrael-PLO\tO\nself-rule\tO\ndeals\tO\n.\tO\n\nOn\tO\nWednesday\tO\na\tO\nbookseller\tO\nin\tO\nthe\tO\nWest\tO\nBank\tO\ntown\tO\nof\tO\nRamallah\tT-1\nsaid\tO\npolice\tT-3\nabout\tO\na\tO\nmonth\tO\nago\tO\nconfiscated\tO\nseveral\tO\ncopies\tO\nof\tO\ntwo\tO\nof\tO\nSaid\tB-PER\n's\tT-0\nbooks\tT-0\non\tO\nthe\tO\nIsrael-PLO\tT-2\nself-rule\tO\ndeals\tO\n.\tO\n\nOn\tO\nWednesday\tT-1\na\tO\nbookseller\tO\nin\tO\nthe\tO\nWest\tO\nBank\tO\ntown\tO\nof\tO\nRamallah\tO\nsaid\tO\npolice\tO\nabout\tO\na\tO\nmonth\tO\nago\tO\nconfiscated\tT-0\nseveral\tO\ncopies\tO\nof\tO\ntwo\tO\nof\tO\nSaid\tO\n's\tO\nbooks\tO\non\tO\nthe\tO\nIsrael-PLO\tB-MISC\nself-rule\tO\ndeals\tO\n.\tO\n\nPalestinian\tB-ORG\nInformation\tI-ORG\nMinistry\tI-ORG\nDirector-General\tO\nMutawakel\tO\nTaha\tO\ndenied\tO\nthat\tO\nministry\tO\nofficials\tO\nforced\tO\nanyone\tO\nto\tO\nsign\tO\nany\tO\nundertaking\tO\nand\tO\ninsisted\tO\nthat\tO\nthe\tO\nPalestinian\tT-0\nAuthority\tO\nhas\tO\nno\tO\nplans\tO\nto\tO\ncensor\tO\nbooks\tO\n.\tO\n\nPalestinian\tT-2\nInformation\tO\nMinistry\tT-1\nDirector-General\tT-1\nMutawakel\tB-PER\nTaha\tI-PER\ndenied\tO\nthat\tO\nministry\tO\nofficials\tO\nforced\tO\nanyone\tO\nto\tO\nsign\tO\nany\tO\nundertaking\tO\nand\tO\ninsisted\tO\nthat\tO\nthe\tO\nPalestinian\tT-0\nAuthority\tT-0\nhas\tO\nno\tO\nplans\tO\nto\tO\ncensor\tO\nbooks\tO\n.\tO\n\nPalestinian\tT-0\nInformation\tT-4\nMinistry\tO\nDirector-General\tT-2\nMutawakel\tO\nTaha\tO\ndenied\tO\nthat\tO\nministry\tO\nofficials\tT-1\nforced\tO\nanyone\tO\nto\tO\nsign\tO\nany\tO\nundertaking\tO\nand\tO\ninsisted\tO\nthat\tO\nthe\tO\nPalestinian\tB-ORG\nAuthority\tI-ORG\nhas\tT-3\nno\tT-3\nplans\tT-3\nto\tO\ncensor\tO\nbooks\tO\n.\tO\n\n\"\tO\nThere\tO\nis\tO\nno\tO\nstrategy\tT-0\nto\tO\nban\tO\nbooks\tO\nor\tO\nto\tO\nsuppress\tO\nfreedom\tT-1\nof\tO\nexpression\tO\nin\tO\nany\tO\nform\tO\nwhatsoever\tO\n,\tO\n\"\tO\nTaha\tB-PER\ntold\tT-2\nReuters\tO\n.\tO\n\n\"\tO\nThere\tO\nis\tO\nno\tO\nstrategy\tO\nto\tO\nban\tT-2\nbooks\tT-3\nor\tO\nto\tO\nsuppress\tT-4\nfreedom\tT-1\nof\tT-1\nexpression\tT-1\nin\tO\nany\tO\nform\tO\nwhatsoever\tO\n,\tO\n\"\tO\nTaha\tO\ntold\tT-0\nReuters\tB-ORG\n.\tO\n\nBut\tO\nTaha\tB-PER\nsaid\tT-1\nthat\tO\nthe\tO\nabsence\tT-2\nof\tO\nrelevent\tO\nlegislations\tO\nmay\tO\nhave\tO\nresulted\tO\nin\tO\nsome\tO\nmistakes\tO\nby\tO\nsome\tO\nsecurity\tT-0\nofficials\tT-0\n.\tO\n\nDaoud\tO\nsaid\tT-1\nbooks\tO\nby\tO\nother\tO\nauthors\tT-2\n,\tO\nincluding\tO\nBritish\tB-MISC\nJournalist\tO\nPatrick\tO\nSeale\tO\n,\tO\nwere\tT-0\nalso\tT-0\nbanned\tT-0\n.\tO\n\nDaoud\tO\nsaid\tO\nbooks\tO\nby\tO\nother\tT-0\nauthors\tT-2\n,\tO\nincluding\tT-1\nBritish\tO\nJournalist\tT-3\nPatrick\tB-PER\nSeale\tI-PER\n,\tO\nwere\tO\nalso\tO\nbanned\tO\n.\tO\n\nDaoud\tB-PER\nsaid\tT-0\n.\tO\n\nThousands\tO\nof\tO\nbooks\tO\nwere\tO\nbanned\tT-0\nfrom\tT-0\nsale\tT-0\nin\tT-0\nthe\tT-0\nWest\tB-LOC\nBank\tI-LOC\nand\tT-1\nGaza\tT-1\nStrip\tT-1\nby\tO\nthe\tO\nIsraeli\tO\nmilitary\tO\nauthorities\tT-2\nbefore\tO\nthe\tO\nJewish\tO\nstate\tO\nhanded\tO\nover\tO\nparts\tO\nof\tO\nthe\tO\ntwo\tO\nareas\tO\nto\tO\nthe\tO\nPLO\tO\nunder\tO\na\tO\nself-rule\tO\ndeal\tO\nin\tO\n1994\tO\n.\tO\n\nThousands\tT-3\nof\tO\nbooks\tO\nwere\tO\nbanned\tT-0\nfrom\tO\nsale\tO\nin\tO\nthe\tO\nWest\tO\nBank\tO\nand\tO\nGaza\tB-LOC\nStrip\tI-LOC\nby\tO\nthe\tO\nIsraeli\tT-1\nmilitary\tT-1\nauthorities\tT-1\nbefore\tO\nthe\tO\nJewish\tO\nstate\tO\nhanded\tO\nover\tO\nparts\tO\nof\tO\nthe\tO\ntwo\tO\nareas\tO\nto\tO\nthe\tO\nPLO\tT-2\nunder\tO\na\tO\nself-rule\tO\ndeal\tO\nin\tO\n1994\tO\n.\tO\n\nThousands\tO\nof\tO\nbooks\tO\nwere\tO\nbanned\tT-1\nfrom\tO\nsale\tO\nin\tO\nthe\tO\nWest\tT-3\nBank\tT-3\nand\tO\nGaza\tT-0\nStrip\tT-0\nby\tO\nthe\tO\nIsraeli\tB-MISC\nmilitary\tT-5\nauthorities\tT-5\nbefore\tO\nthe\tO\nJewish\tO\nstate\tO\nhanded\tT-2\nover\tT-2\nparts\tO\nof\tO\nthe\tO\ntwo\tO\nareas\tO\nto\tO\nthe\tO\nPLO\tT-4\nunder\tO\na\tO\nself-rule\tO\ndeal\tO\nin\tO\n1994\tO\n.\tO\n\nThousands\tO\nof\tO\nbooks\tO\nwere\tO\nbanned\tT-0\nfrom\tO\nsale\tO\nin\tO\nthe\tO\nWest\tO\nBank\tO\nand\tO\nGaza\tO\nStrip\tO\nby\tO\nthe\tO\nIsraeli\tO\nmilitary\tO\nauthorities\tO\nbefore\tO\nthe\tO\nJewish\tB-MISC\nstate\tT-1\nhanded\tO\nover\tO\nparts\tO\nof\tO\nthe\tO\ntwo\tO\nareas\tO\nto\tO\nthe\tO\nPLO\tO\nunder\tO\na\tO\nself-rule\tO\ndeal\tO\nin\tO\n1994\tO\n.\tO\n\nThousands\tO\nof\tO\nbooks\tO\nwere\tO\nbanned\tO\nfrom\tO\nsale\tO\nin\tO\nthe\tO\nWest\tT-3\nBank\tT-3\nand\tO\nGaza\tO\nStrip\tO\nby\tO\nthe\tO\nIsraeli\tO\nmilitary\tO\nauthorities\tO\nbefore\tO\nthe\tO\nJewish\tT-1\nstate\tT-1\nhanded\tO\nover\tO\nparts\tO\nof\tO\nthe\tO\ntwo\tT-2\nareas\tT-2\nto\tT-0\nthe\tT-0\nPLO\tB-ORG\nunder\tO\na\tO\nself-rule\tO\ndeal\tO\nin\tO\n1994\tO\n.\tO\n\nEgypt\tB-LOC\nblames\tT-2\nIstanbul\tT-0\ncontrol\tT-3\ntower\tO\nfor\tO\naccident\tT-1\n.\tO\n\nEgypt\tT-0\nblames\tO\nIstanbul\tB-LOC\ncontrol\tT-1\ntower\tO\nfor\tO\naccident\tO\n.\tO\n\nThe\tO\nchairman\tO\nof\tO\nnational\tO\ncarrier\tT-0\nEgyptAir\tB-ORG\non\tO\nThursday\tO\nblamed\tO\nthe\tO\ncontrol\tO\ntower\tO\nat\tO\nIstanbul\tO\nairport\tO\nfor\tO\nthe\tO\nEgyptAir\tT-1\nplane\tO\naccident\tO\n.\tO\n\nThe\tO\nchairman\tO\nof\tO\nnational\tO\ncarrier\tO\nEgyptAir\tO\non\tO\nThursday\tO\nblamed\tO\nthe\tO\ncontrol\tO\ntower\tO\nat\tT-0\nIstanbul\tB-LOC\nairport\tO\nfor\tO\nthe\tO\nEgyptAir\tO\nplane\tO\naccident\tO\n.\tO\n\nThe\tO\nchairman\tT-2\nof\tO\nnational\tO\ncarrier\tO\nEgyptAir\tO\non\tO\nThursday\tO\nblamed\tT-4\nthe\tO\ncontrol\tO\ntower\tO\nat\tO\nIstanbul\tO\nairport\tO\nfor\tT-0\nthe\tT-0\nEgyptAir\tB-ORG\nplane\tT-1\naccident\tT-1\n.\tO\n\nTwenty\tO\npeople\tO\nwere\tO\ninjured\tO\non\tO\nWednesday\tO\nwhen\tO\nthe\tO\nEgyptAir\tB-ORG\nBoeing\tO\n707\tO\novershot\tO\nthe\tO\nrunway\tO\n,\tO\ncaught\tT-0\nfire\tT-0\n,\tO\nhit\tO\na\tO\ntaxi\tO\nand\tO\nskipped\tO\nacross\tO\na\tO\nroad\tO\nonto\tO\na\tO\nrailway\tO\nline\tO\n.\tO\n\nTwenty\tT-1\npeople\tO\nwere\tO\ninjured\tO\non\tO\nWednesday\tO\nwhen\tO\nthe\tO\nEgyptAir\tT-0\nBoeing\tB-MISC\n707\tO\novershot\tO\nthe\tO\nrunway\tO\n,\tO\ncaught\tO\nfire\tO\n,\tO\nhit\tO\na\tO\ntaxi\tO\nand\tO\nskipped\tO\nacross\tO\na\tO\nroad\tO\nonto\tO\na\tO\nrailway\tO\nline\tO\n.\tO\n\nChairman\tT-0\nMohamed\tB-PER\nFahim\tI-PER\nRayyan\tI-PER\ntold\tT-1\na\tO\nnews\tT-2\nconference\tT-2\nat\tO\nCairo\tO\nairport\tO\n:\tO\n\"\tO\nThe\tO\ncontrol\tO\ntower\tO\nshould\tO\nhave\tO\nallocated\tO\nthe\tO\nplane\tO\nanother\tO\nrunway\tO\n,\tO\ninstead\tO\nof\tO\nthe\tO\none\tO\nthe\tO\nplane\tO\nlanded\tO\non\tO\n.\tO\n\"\tO\n\nHe\tO\nsaid\tO\na\tO\nTurkish\tB-MISC\ncivil\tO\naviation\tO\nauthority\tT-0\nofficial\tO\nhad\tO\nmade\tO\nthe\tO\nsame\tO\npoint\tO\nand\tO\nhe\tO\nnoted\tO\nthat\tO\na\tO\nTurkish\tO\nplane\tO\nhad\tO\na\tO\nsimilar\tO\naccident\tO\nthere\tO\nin\tO\n1994\tO\n.\tO\n\nHe\tO\nsaid\tT-2\na\tO\nTurkish\tO\ncivil\tO\naviation\tO\nauthority\tT-3\nofficial\tO\nhad\tO\nmade\tO\nthe\tO\nsame\tO\npoint\tO\nand\tO\nhe\tO\nnoted\tT-1\nthat\tO\na\tO\nTurkish\tB-MISC\nplane\tT-0\nhad\tO\na\tO\nsimilar\tO\naccident\tO\nthere\tO\nin\tO\n1994\tO\n.\tO\n\nThe\tO\nEgyptAir\tB-ORG\npilot\tT-0\nblamed\tO\nTurkish\tO\nairport\tO\nstaff\tO\nfor\tO\nmisleading\tO\nhim\tO\n.\tO\n\nThe\tO\nEgyptAir\tT-0\npilot\tT-1\nblamed\tO\nTurkish\tB-MISC\nairport\tT-2\nstaff\tT-2\nfor\tO\nmisleading\tO\nhim\tO\n.\tO\n\nThat\tO\n's\tO\nwrong\tO\n,\tO\n\"\tO\nthe\tT-0\npilot\tT-0\ntold\tO\nprivate\tO\nIhlas\tB-ORG\nnews\tO\nagency\tO\nin\tO\nEnglish\tO\n.\tT-1\n\nThat\tO\n's\tO\nwrong\tO\n,\tO\n\"\tO\nthe\tO\npilot\tT-0\ntold\tT-1\nprivate\tO\nIhlas\tO\nnews\tO\nagency\tT-2\nin\tO\nEnglish\tB-MISC\n.\tO\n\nEgypt\tB-LOC\nwants\tT-0\nnothing\tO\nto\tO\ndo\tO\nwith\tO\nSudanese\tT-1\nrulers\tT-1\n.\tO\n\nEgypt\tT-0\nwants\tO\nnothing\tO\nto\tO\ndo\tO\nwith\tO\nSudanese\tB-MISC\nrulers\tO\n.\tO\n\nThe\tO\nEgyptian\tB-MISC\ngovernment\tT-0\nwill\tT-1\nhave\tT-1\nnothing\tO\nmore\tO\nto\tO\ndo\tO\nwith\tO\nthe\tO\nSudanese\tT-2\ngovernment\tT-2\nbecause\tO\nit\tO\ncontinues\tO\nto\tO\nshelter\tO\nand\tO\nsupport\tO\nEgyptian\tO\nmilitants\tO\n,\tO\nPresident\tO\nHosni\tO\nMubarak\tO\nsaid\tO\nin\tO\na\tO\nspeech\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nEgyptian\tT-0\ngovernment\tT-0\nwill\tO\nhave\tO\nnothing\tO\nmore\tO\nto\tO\ndo\tO\nwith\tO\nthe\tO\nSudanese\tB-MISC\ngovernment\tO\nbecause\tO\nit\tO\ncontinues\tO\nto\tO\nshelter\tT-1\nand\tT-1\nsupport\tT-1\nEgyptian\tO\nmilitants\tO\n,\tO\nPresident\tO\nHosni\tO\nMubarak\tO\nsaid\tO\nin\tO\na\tO\nspeech\tO\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nEgyptian\tO\ngovernment\tO\nwill\tO\nhave\tO\nnothing\tO\nmore\tO\nto\tO\ndo\tO\nwith\tO\nthe\tO\nSudanese\tO\ngovernment\tO\nbecause\tO\nit\tO\ncontinues\tO\nto\tO\nshelter\tO\nand\tO\nsupport\tT-0\nEgyptian\tB-MISC\nmilitants\tO\n,\tO\nPresident\tO\nHosni\tO\nMubarak\tO\nsaid\tO\nin\tO\na\tO\nspeech\tT-1\non\tO\nThursday\tO\n.\tO\n\nThe\tO\nEgyptian\tT-2\ngovernment\tO\nwill\tO\nhave\tO\nnothing\tO\nmore\tO\nto\tO\ndo\tO\nwith\tO\nthe\tO\nSudanese\tO\ngovernment\tO\nbecause\tO\nit\tO\ncontinues\tO\nto\tO\nshelter\tT-0\nand\tO\nsupport\tT-1\nEgyptian\tO\nmilitants\tO\n,\tO\nPresident\tT-3\nHosni\tB-PER\nMubarak\tI-PER\nsaid\tO\nin\tO\na\tO\nspeech\tO\non\tO\nThursday\tO\n.\tO\n\nEgypt\tB-LOC\nsays\tO\nthe\tO\nSudanese\tO\ngovernment\tT-2\nhelped\tT-0\nthe\tO\nMoslem\tT-1\nmilitants\tT-1\nwho\tO\ntried\tO\nto\tO\nkill\tO\nMubarak\tO\nin\tO\nAddis\tO\nAbaba\tO\nlast\tO\nyear\tO\n.\tO\n\nEgypt\tO\nsays\tO\nthe\tO\nSudanese\tB-MISC\ngovernment\tO\nhelped\tT-0\nthe\tO\nMoslem\tO\nmilitants\tO\nwho\tO\ntried\tO\nto\tO\nkill\tO\nMubarak\tO\nin\tO\nAddis\tO\nAbaba\tO\nlast\tT-1\nyear\tT-1\n.\tO\n\nEgypt\tT-0\nsays\tO\nthe\tO\nSudanese\tT-1\ngovernment\tO\nhelped\tT-3\nthe\tO\nMoslem\tB-MISC\nmilitants\tT-4\nwho\tO\ntried\tO\nto\tO\nkill\tO\nMubarak\tT-2\nin\tO\nAddis\tO\nAbaba\tO\nlast\tO\nyear\tO\n.\tO\n\nEgypt\tO\nsays\tO\nthe\tO\nSudanese\tT-0\ngovernment\tT-0\nhelped\tT-2\nthe\tO\nMoslem\tT-3\nmilitants\tT-3\nwho\tO\ntried\tO\nto\tO\nkill\tT-1\nMubarak\tB-PER\nin\tO\nAddis\tO\nAbaba\tO\nlast\tO\nyear\tO\n.\tO\n\nEgypt\tT-1\nsays\tO\nthe\tO\nSudanese\tO\ngovernment\tO\nhelped\tO\nthe\tO\nMoslem\tO\nmilitants\tO\nwho\tO\ntried\tO\nto\tO\nkill\tO\nMubarak\tT-2\nin\tT-0\nAddis\tB-LOC\nAbaba\tI-LOC\nlast\tO\nyear\tO\n.\tO\n\nIt\tT-0\nsponsored\tT-0\nlast\tT-0\nweek\tT-0\n's\tT-0\nU.N.\tB-ORG\nSecurity\tI-ORG\nCouncil\tI-ORG\nresolution\tT-1\nthreatening\tT-1\na\tT-1\nban\tT-1\non\tT-1\nSudanese\tT-1\nflights\tO\nabroad\tO\nif\tO\nKhartoum\tO\ndoes\tO\nnot\tO\nhand\tO\nover\tO\nthree\tO\nmen\tO\naccused\tO\nin\tO\nthe\tO\nAddis\tO\nAbaba\tO\nincident\tO\n.\tO\n\nIt\tO\nsponsored\tO\nlast\tO\nweek\tO\n's\tO\nU.N.\tO\nSecurity\tO\nCouncil\tO\nresolution\tO\nthreatening\tO\na\tO\nban\tO\non\tO\nSudanese\tB-MISC\nflights\tT-0\nabroad\tO\nif\tO\nKhartoum\tO\ndoes\tO\nnot\tO\nhand\tO\nover\tO\nthree\tO\nmen\tO\naccused\tO\nin\tO\nthe\tO\nAddis\tO\nAbaba\tO\nincident\tO\n.\tO\n\nIt\tT-0\nsponsored\tT-5\nlast\tO\nweek\tO\n's\tO\nU.N.\tO\nSecurity\tO\nCouncil\tO\nresolution\tO\nthreatening\tT-2\na\tO\nban\tO\non\tO\nSudanese\tO\nflights\tO\nabroad\tO\nif\tO\nKhartoum\tB-LOC\ndoes\tT-1\nnot\tT-1\nhand\tO\nover\tO\nthree\tO\nmen\tO\naccused\tT-3\nin\tO\nthe\tO\nAddis\tO\nAbaba\tO\nincident\tT-4\n.\tO\n\nIt\tO\nsponsored\tO\nlast\tO\nweek\tO\n's\tO\nU.N.\tO\nSecurity\tO\nCouncil\tO\nresolution\tO\nthreatening\tO\na\tO\nban\tO\non\tO\nSudanese\tO\nflights\tO\nabroad\tO\nif\tO\nKhartoum\tO\ndoes\tO\nnot\tO\nhand\tO\nover\tO\nthree\tO\nmen\tO\naccused\tO\nin\tO\nthe\tO\nAddis\tB-LOC\nAbaba\tI-LOC\nincident\tT-0\n.\tO\n\nThe\tO\nsanctions\tO\nwill\tO\ncome\tO\ninto\tO\neffect\tO\nin\tO\nNovember\tO\nif\tT-0\nSudan\tB-LOC\nfails\tO\nto\tO\nextradite\tT-1\nthe\tO\nmen\tO\n,\tO\nbut\tO\nSudan\tO\nsays\tO\nit\tO\ncannot\tO\nhand\tO\nthem\tO\nover\tO\nto\tO\nEthiopia\tO\nfor\tO\ntrial\tO\nbecause\tO\nthey\tO\nare\tO\nnot\tO\nin\tO\nSudan\tO\n.\tO\n\nThe\tO\nsanctions\tT-1\nwill\tO\ncome\tO\ninto\tO\neffect\tO\nin\tO\nNovember\tO\nif\tO\nSudan\tO\nfails\tO\nto\tO\nextradite\tT-2\nthe\tO\nmen\tO\n,\tO\nbut\tO\nSudan\tB-LOC\nsays\tO\nit\tO\ncannot\tO\nhand\tO\nthem\tO\nover\tO\nto\tO\nEthiopia\tO\nfor\tO\ntrial\tT-0\nbecause\tO\nthey\tO\nare\tO\nnot\tO\nin\tO\nSudan\tO\n.\tO\n\nThe\tO\nsanctions\tO\nwill\tO\ncome\tO\ninto\tO\neffect\tT-1\nin\tO\nNovember\tO\nif\tO\nSudan\tO\nfails\tT-2\nto\tO\nextradite\tO\nthe\tO\nmen\tO\n,\tO\nbut\tO\nSudan\tO\nsays\tT-3\nit\tO\ncannot\tO\nhand\tO\nthem\tO\nover\tO\nto\tT-0\nEthiopia\tB-LOC\nfor\tO\ntrial\tO\nbecause\tO\nthey\tO\nare\tO\nnot\tO\nin\tO\nSudan\tO\n.\tO\n\nThe\tO\nsanctions\tO\nwill\tO\ncome\tO\ninto\tO\neffect\tO\nin\tO\nNovember\tO\nif\tO\nSudan\tO\nfails\tO\nto\tO\nextradite\tO\nthe\tO\nmen\tO\n,\tO\nbut\tO\nSudan\tT-1\nsays\tO\nit\tO\ncannot\tO\nhand\tO\nthem\tO\nover\tO\nto\tO\nEthiopia\tT-2\nfor\tO\ntrial\tO\nbecause\tO\nthey\tO\nare\tO\nnot\tO\nin\tT-0\nSudan\tB-LOC\n.\tO\n\n\"\tO\nWe\tO\nare\tO\nstill\tO\neager\tO\nthat\tO\nnothing\tO\nshould\tO\naffect\tT-0\nthe\tO\nSudanese\tB-MISC\npeople\tT-3\nbut\tO\nwe\tO\nwill\tO\nnot\tO\ndeal\tT-1\nwith\tO\nthe\tO\ncurrent\tO\nregime\tT-4\nor\tO\nthe\tO\nTurabi\tO\nfront\tO\nor\tO\nwhatever\tO\n,\tO\n\"\tO\nMubarak\tO\ntold\tT-2\na\tO\ngroup\tO\nof\tO\nacademics\tO\n.\tO\n\n\"\tO\nWe\tO\nare\tO\nstill\tO\neager\tT-0\nthat\tO\nnothing\tO\nshould\tO\naffect\tO\nthe\tO\nSudanese\tO\npeople\tO\nbut\tO\nwe\tO\nwill\tO\nnot\tO\ndeal\tO\nwith\tO\nthe\tO\ncurrent\tO\nregime\tO\nor\tO\nthe\tT-3\nTurabi\tB-PER\nfront\tT-2\nor\tO\nwhatever\tO\n,\tO\n\"\tO\nMubarak\tO\ntold\tT-1\na\tO\ngroup\tO\nof\tO\nacademics\tO\n.\tO\n\n\"\tO\nWe\tT-1\nare\tO\nstill\tO\neager\tT-0\nthat\tO\nnothing\tO\nshould\tO\naffect\tO\nthe\tO\nSudanese\tO\npeople\tT-2\nbut\tO\nwe\tO\nwill\tO\nnot\tO\ndeal\tO\nwith\tO\nthe\tO\ncurrent\tO\nregime\tO\nor\tO\nthe\tO\nTurabi\tO\nfront\tO\nor\tO\nwhatever\tO\n,\tO\n\"\tO\nMubarak\tB-PER\ntold\tT-3\na\tO\ngroup\tO\nof\tO\nacademics\tO\n.\tO\n\nHassan\tB-PER\nal-Turabi\tI-PER\nis\tO\nthe\tO\nleader\tT-0\nof\tO\nthe\tO\nNational\tT-2\nIslamic\tT-2\nFront\tO\n,\tO\nthe\tO\npolitical\tT-1\nforce\tT-1\nbehind\tO\nthe\tO\nSudanese\tT-3\ngovernment\tO\n.\tO\n\nHassan\tO\nal-Turabi\tO\nis\tO\nthe\tO\nleader\tT-0\nof\tO\nthe\tO\nNational\tB-ORG\nIslamic\tI-ORG\nFront\tI-ORG\n,\tO\nthe\tO\npolitical\tT-2\nforce\tT-2\nbehind\tT-1\nthe\tT-1\nSudanese\tO\ngovernment\tO\n.\tO\n\nHassan\tO\nal-Turabi\tO\nis\tO\nthe\tO\nleader\tT-2\nof\tO\nthe\tO\nNational\tT-0\nIslamic\tO\nFront\tO\n,\tO\nthe\tO\npolitical\tO\nforce\tO\nbehind\tO\nthe\tO\nSudanese\tB-MISC\ngovernment\tT-1\n.\tO\n\nThere\tO\nare\tO\nterrorists\tO\nthey\tT-0\nare\tO\nsheltering\tO\nand\tO\nthey\tO\nmake\tO\nSudanese\tB-MISC\npassorts\tT-2\nfor\tO\nthem\tT-1\nand\tO\nthey\tO\nget\tO\npaid\tO\nby\tO\nthem\tO\n,\tO\n\"\tO\nMubarak\tO\nsaid\tO\n.\tO\n\nThere\tO\nare\tO\nterrorists\tT-1\nthey\tO\nare\tO\nsheltering\tT-2\nand\tO\nthey\tO\nmake\tO\nSudanese\tO\npassorts\tO\nfor\tO\nthem\tO\nand\tO\nthey\tO\nget\tO\npaid\tT-0\nby\tO\nthem\tO\n,\tO\n\"\tO\nMubarak\tB-PER\nsaid\tO\n.\tO\n\nHe\tO\ndid\tO\nnot\tO\nsay\tO\nif\tO\nEgypt\tB-LOC\nwould\tO\ngo\tO\nso\tO\nfar\tO\nas\tO\nto\tO\nbreak\tT-0\nrelations\tO\n,\tO\na\tO\nstep\tO\nit\tO\nhas\tO\nbeen\tO\nreluctant\tO\nto\tO\ntake\tO\n,\tO\nostensibly\tO\nbecause\tO\nit\tO\nwould\tO\naffect\tO\nordinary\tO\nSudanese\tT-1\n.\tO\n\nHe\tO\ndid\tO\nnot\tO\nsay\tO\nif\tO\nEgypt\tO\nwould\tO\ngo\tO\nso\tO\nfar\tO\nas\tO\nto\tO\nbreak\tO\nrelations\tT-0\n,\tO\na\tO\nstep\tO\nit\tO\nhas\tO\nbeen\tO\nreluctant\tO\nto\tO\ntake\tO\n,\tO\nostensibly\tO\nbecause\tO\nit\tO\nwould\tO\naffect\tO\nordinary\tO\nSudanese\tB-MISC\n.\tO\n\nTurkish\tB-MISC\nshares\tT-1\nshed\tO\ngains\tT-0\nin\tO\nprofit-taking\tT-2\n.\tO\n\nTurkish\tB-MISC\nshares\tT-0\nended\tO\nlower\tO\non\tO\nThursday\tO\n,\tO\nshedding\tO\ngains\tO\nof\tO\nearlier\tO\nin\tO\nthe\tO\nweek\tO\namid\tO\nprofit-taking\tO\nsales\tO\n,\tO\nbrokers\tO\nsaid\tO\n.\tO\n\nThe\tO\nIMKB-100\tB-MISC\nlost\tO\n0.19\tO\npercent\tO\nor\tO\n123.89\tO\npoints\tO\nto\tO\nend\tT-0\nat\tO\n64,178.78\tO\n.\tO\n\nI\tO\nexpect\tT-2\nthe\tO\nmarket\tO\nto\tO\ngo\tO\nas\tO\nfar\tO\ndown\tO\nas\tO\n63,000\tO\ntomorrow\tO\nif\tO\nsales\tO\ncontinue\tO\n,\tO\n\"\tO\nsaid\tT-1\nBurcin\tB-PER\nMavituna\tI-PER\nfrom\tO\nInterbank\tT-0\n.\tO\n\nI\tO\nexpect\tO\nthe\tO\nmarket\tO\nto\tO\ngo\tO\nas\tO\nfar\tO\ndown\tO\nas\tO\n63,000\tO\ntomorrow\tT-0\nif\tO\nsales\tO\ncontinue\tO\n,\tO\n\"\tO\nsaid\tO\nBurcin\tT-1\nMavituna\tT-2\nfrom\tO\nInterbank\tB-ORG\n.\tO\n\nThe\tO\nsession\tT-0\n's\tO\nmost\tO\nactive\tT-2\nshares\tO\nwere\tO\nthose\tO\nof\tO\nIsbank\tB-ORG\ngained\tT-3\n300\tO\nlira\tT-1\nto\tO\n8,600\tO\n.\tO\n\nShares\tO\nof\tO\nutility\tO\nCukurova\tB-ORG\nlost\tT-0\n3,000\tO\nlira\tO\nto\tO\n67,000\tO\n.\tO\n\n--\tO\nIstanbul\tB-ORG\nNewsroom\tI-ORG\n,\tO\n+90-212-275\tT-0\n0875\tO\nSA\tO\n\nMiss\tB-MISC\nUniverse\tI-MISC\nhides\tT-0\nbehind\tO\nveil\tT-1\nof\tO\nsilence\tO\n.\tO\n\nMiss\tB-MISC\nUniverse\tI-MISC\n,\tO\nVenezuela\tT-1\n's\tO\nAlicia\tO\nMachado\tO\n,\tO\nleft\tT-0\nNew\tT-0\nMexico\tT-0\non\tT-0\nThursday\tT-0\n,\tO\nrefusing\tO\nto\tO\nanswer\tO\nquestions\tO\nabout\tO\nher\tO\nweight\tO\nor\tO\nclaims\tO\nshe\tO\nwas\tO\ntold\tO\nto\tO\neither\tO\ngo\tO\non\tO\na\tO\ncrash\tO\ndiet\tO\nor\tO\ngive\tO\nup\tO\nher\tO\ntitle\tO\n.\tO\n\nMiss\tO\nUniverse\tO\n,\tO\nVenezuela\tB-LOC\n's\tO\nAlicia\tO\nMachado\tO\n,\tO\nleft\tT-1\nNew\tT-0\nMexico\tT-0\non\tO\nThursday\tO\n,\tO\nrefusing\tO\nto\tO\nanswer\tT-2\nquestions\tO\nabout\tO\nher\tO\nweight\tO\nor\tO\nclaims\tO\nshe\tO\nwas\tO\ntold\tO\nto\tO\neither\tO\ngo\tO\non\tO\na\tO\ncrash\tO\ndiet\tT-3\nor\tO\ngive\tO\nup\tO\nher\tO\ntitle\tO\n.\tO\n\nMiss\tT-0\nUniverse\tT-0\n,\tO\nVenezuela\tT-1\n's\tT-1\nAlicia\tB-PER\nMachado\tI-PER\n,\tO\nleft\tO\nNew\tO\nMexico\tO\non\tO\nThursday\tT-2\n,\tO\nrefusing\tO\nto\tO\nanswer\tO\nquestions\tO\nabout\tO\nher\tO\nweight\tO\nor\tO\nclaims\tO\nshe\tO\nwas\tO\ntold\tO\nto\tO\neither\tO\ngo\tO\non\tO\na\tO\ncrash\tO\ndiet\tO\nor\tO\ngive\tO\nup\tO\nher\tO\ntitle\tO\n.\tO\n\nMachado\tB-PER\n,\tO\n19\tO\n,\tO\nflew\tT-3\nto\tT-3\nLos\tT-0\nAngeles\tT-0\nafter\tO\nslipping\tT-4\naway\tT-4\nfrom\tO\nthe\tO\nNew\tT-1\nMexico\tT-1\ndesert\tO\ntown\tO\nof\tO\nLas\tT-2\nCruces\tT-2\n,\tO\nwhere\tO\nshe\tO\nattended\tT-5\nthe\tO\n1996\tO\nMiss\tO\nTeen\tO\nUSA\tO\npageant\tO\non\tO\nWednesday\tO\n.\tO\n\nMachado\tO\n,\tO\n19\tO\n,\tO\nflew\tT-0\nto\tO\nLos\tB-LOC\nAngeles\tI-LOC\nafter\tO\nslipping\tT-1\naway\tO\nfrom\tO\nthe\tO\nNew\tO\nMexico\tO\ndesert\tO\ntown\tO\nof\tO\nLas\tO\nCruces\tO\n,\tO\nwhere\tO\nshe\tO\nattended\tO\nthe\tO\n1996\tO\nMiss\tO\nTeen\tO\nUSA\tO\npageant\tO\non\tO\nWednesday\tO\n.\tO\n\nMachado\tT-1\n,\tO\n19\tO\n,\tO\nflew\tO\nto\tO\nLos\tT-3\nAngeles\tT-3\nafter\tO\nslipping\tO\naway\tO\nfrom\tO\nthe\tT-0\nNew\tB-LOC\nMexico\tI-LOC\ndesert\tT-4\ntown\tT-4\nof\tT-4\nLas\tT-4\nCruces\tT-4\n,\tO\nwhere\tO\nshe\tO\nattended\tO\nthe\tO\n1996\tO\nMiss\tT-2\nTeen\tT-2\nUSA\tT-2\npageant\tT-2\non\tO\nWednesday\tO\n.\tO\n\nMachado\tO\n,\tO\n19\tO\n,\tO\nflew\tO\nto\tO\nLos\tO\nAngeles\tO\nafter\tO\nslipping\tO\naway\tO\nfrom\tO\nthe\tO\nNew\tT-1\nMexico\tT-1\ndesert\tT-1\ntown\tT-3\nof\tT-3\nLas\tB-LOC\nCruces\tI-LOC\n,\tO\nwhere\tT-0\nshe\tO\nattended\tO\nthe\tO\n1996\tT-2\nMiss\tT-2\nTeen\tT-2\nUSA\tT-2\npageant\tT-2\non\tO\nWednesday\tO\n.\tO\n\nMachado\tO\n,\tO\n19\tO\n,\tO\nflew\tO\nto\tO\nLos\tO\nAngeles\tO\nafter\tO\nslipping\tO\naway\tO\nfrom\tT-2\nthe\tT-2\nNew\tO\nMexico\tO\ndesert\tO\ntown\tO\nof\tO\nLas\tT-1\nCruces\tT-1\n,\tO\nwhere\tO\nshe\tO\nattended\tO\nthe\tO\n1996\tB-MISC\nMiss\tI-MISC\nTeen\tI-MISC\nUSA\tI-MISC\npageant\tT-0\non\tO\nWednesday\tO\n.\tO\n\nWhile\tO\nMachado\tB-PER\nwas\tT-2\nnot\tT-2\na\tO\ncontestant\tO\nhere\tO\n,\tO\nshe\tO\ncame\tT-0\nunder\tT-0\nintense\tT-0\nscrutiny\tT-0\nfollowing\tO\nreports\tO\nshe\tO\nwas\tO\ngiven\tT-1\nan\tT-1\nultimatum\tT-1\nby\tO\nLos\tO\nAngeles-based\tO\nMiss\tO\nUniverse\tO\nInc.\tO\nto\tO\ndrop\tO\n27\tO\npounds\tO\n(\tO\n12\tO\nkg\tO\n)\tO\nin\tO\ntwo\tO\nweeks\tO\nor\tO\nrisk\tO\nlosing\tO\nher\tO\ncrown\tO\n.\tO\n\nWhile\tO\nMachado\tT-0\nwas\tO\nnot\tO\na\tO\ncontestant\tO\nhere\tO\n,\tO\nshe\tT-1\ncame\tO\nunder\tO\nintense\tO\nscrutiny\tO\nfollowing\tO\nreports\tO\nshe\tO\nwas\tO\ngiven\tO\nan\tO\nultimatum\tO\nby\tO\nLos\tB-MISC\nAngeles-based\tI-MISC\nMiss\tT-2\nUniverse\tT-2\nInc.\tT-2\nto\tO\ndrop\tO\n27\tO\npounds\tO\n(\tO\n12\tO\nkg\tO\n)\tO\nin\tO\ntwo\tO\nweeks\tO\nor\tO\nrisk\tO\nlosing\tO\nher\tO\ncrown\tO\n.\tO\n\nWhile\tO\nMachado\tT-1\nwas\tO\nnot\tO\na\tO\ncontestant\tO\nhere\tO\n,\tO\nshe\tO\ncame\tO\nunder\tO\nintense\tO\nscrutiny\tO\nfollowing\tO\nreports\tO\nshe\tO\nwas\tO\ngiven\tO\nan\tO\nultimatum\tO\nby\tO\nLos\tO\nAngeles-based\tT-0\nMiss\tB-ORG\nUniverse\tI-ORG\nInc.\tI-ORG\nto\tO\ndrop\tO\n27\tO\npounds\tO\n(\tO\n12\tO\nkg\tO\n)\tO\nin\tO\ntwo\tO\nweeks\tO\nor\tO\nrisk\tT-2\nlosing\tO\nher\tO\ncrown\tO\n.\tT-0\n\nIn\tT-0\nVenezuela\tB-LOC\n,\tO\nher\tO\nmother\tO\ntold\tO\nReuters\tO\nthat\tO\nMachado\tO\nhad\tO\na\tO\nswollen\tO\nface\tO\nwhen\tO\nshe\tO\nleft\tT-1\nhome\tO\ntwo\tO\nweeks\tO\nago\tO\nbecause\tO\nshe\tO\nhad\tO\nher\tO\nwisdom\tO\nteeth\tO\nextracted\tO\n.\tO\n\nIn\tO\nVenezuela\tO\n,\tO\nher\tO\nmother\tO\ntold\tT-2\nReuters\tB-ORG\nthat\tO\nMachado\tO\nhad\tO\na\tO\nswollen\tT-0\nface\tO\nwhen\tO\nshe\tO\nleft\tO\nhome\tO\ntwo\tO\nweeks\tO\nago\tO\nbecause\tO\nshe\tO\nhad\tO\nher\tO\nwisdom\tO\nteeth\tO\nextracted\tT-1\n.\tO\n\nIn\tO\nVenezuela\tO\n,\tO\nher\tO\nmother\tT-2\ntold\tO\nReuters\tO\nthat\tT-1\nMachado\tB-PER\nhad\tO\na\tO\nswollen\tO\nface\tT-0\nwhen\tO\nshe\tO\nleft\tO\nhome\tO\ntwo\tO\nweeks\tO\nago\tO\nbecause\tO\nshe\tO\nhad\tO\nher\tO\nwisdom\tO\nteeth\tO\nextracted\tO\n.\tO\n\nMarta\tB-PER\nFajardo\tI-PER\ninsisted\tT-2\nher\tO\ndaughter\tT-0\n,\tO\nwho\tO\nweighed\tT-4\n112\tO\npounds\tO\n(\tO\n51\tO\nkg\tO\n)\tO\nwhen\tO\nshe\tT-3\nwon\tT-5\nthe\tO\nMiss\tT-1\nUniverse\tT-1\ntitle\tO\nin\tO\nLas\tO\nVegas\tO\nin\tO\nMay\tO\n,\tO\nhad\tO\nperfectly\tO\nnormal\tO\neating\tO\nhabits\tO\n.\tO\n\nMarta\tO\nFajardo\tO\ninsisted\tT-1\nher\tO\ndaughter\tO\n,\tO\nwho\tO\nweighed\tO\n112\tO\npounds\tO\n(\tO\n51\tO\nkg\tO\n)\tO\nwhen\tO\nshe\tO\nwon\tT-0\nthe\tT-0\nMiss\tB-MISC\nUniverse\tI-MISC\ntitle\tO\nin\tO\nLas\tO\nVegas\tO\nin\tO\nMay\tO\n,\tO\nhad\tO\nperfectly\tO\nnormal\tO\neating\tO\nhabits\tO\n.\tO\n\nMarta\tO\nFajardo\tO\ninsisted\tT-1\nher\tO\ndaughter\tO\n,\tO\nwho\tO\nweighed\tO\n112\tO\npounds\tO\n(\tO\n51\tO\nkg\tO\n)\tO\nwhen\tO\nshe\tO\nwon\tO\nthe\tO\nMiss\tO\nUniverse\tO\ntitle\tO\nin\tT-0\nLas\tB-LOC\nVegas\tI-LOC\nin\tO\nMay\tO\n,\tO\nhad\tO\nperfectly\tO\nnormal\tO\neating\tT-2\nhabits\tO\n.\tO\n\nOrganisers\tO\nflatly\tO\ndenied\tT-0\never\tO\nthreatening\tT-2\nMachado\tB-PER\nbut\tO\nimmediately\tO\nput\tO\nher\tO\nunder\tO\nwraps\tO\nand\tO\nblocked\tO\naccess\tT-1\nto\tT-1\nher\tT-1\n.\tO\n\nDressed\tO\nin\tO\na\tO\nblack\tO\nstrapless\tO\nevening\tO\ngown\tO\nat\tO\nWednesday\tO\n's\tO\npageant\tT-1\n,\tO\nMachado\tB-PER\nwas\tT-0\nclearly\tT-0\nheavier\tO\nthan\tO\nthe\tO\ncontestants\tO\nbut\tO\nstill\tO\nwon\tT-2\nrave\tO\nreviews\tO\nafter\tO\nher\tO\nbrief\tO\nappearance\tO\non\tO\nstage\tO\n.\tO\n\nShe\tO\n's\tO\nfantastic\tO\n,\tO\n\"\tO\nsaid\tO\nNikki\tB-PER\nCampbell\tI-PER\n,\tO\n28\tT-1\n,\tO\nwho\tO\nwent\tO\nto\tO\nthe\tO\npageant\tT-0\n.\tO\n\"\tO\n\nMachado\tB-PER\n's\tO\npublicists\tT-0\nsaid\tT-1\non\tO\nThursday\tO\nshe\tO\nwas\tO\nscheduled\tO\nto\tO\nstay\tO\nin\tO\nLos\tO\nAngeles\tO\nfor\tO\npromotional\tO\nwork\tO\nwith\tO\nsponsors\tO\nbefore\tO\nreturning\tO\nto\tO\nVenezuela\tO\non\tO\nSept\tO\n.\tO\n\nMachado\tT-2\n's\tO\npublicists\tO\nsaid\tO\non\tO\nThursday\tO\nshe\tO\nwas\tO\nscheduled\tT-0\nto\tO\nstay\tT-1\nin\tT-1\nLos\tB-LOC\nAngeles\tI-LOC\nfor\tO\npromotional\tO\nwork\tO\nwith\tO\nsponsors\tO\nbefore\tO\nreturning\tO\nto\tO\nVenezuela\tO\non\tO\nSept\tO\n.\tO\n\nMachado\tT-2\n's\tO\npublicists\tT-0\nsaid\tO\non\tO\nThursday\tO\nshe\tO\nwas\tO\nscheduled\tO\nto\tO\nstay\tO\nin\tO\nLos\tT-3\nAngeles\tT-3\nfor\tO\npromotional\tO\nwork\tO\nwith\tO\nsponsors\tT-1\nbefore\tO\nreturning\tT-4\nto\tT-4\nVenezuela\tB-LOC\non\tO\nSept\tO\n.\tO\n\nBeauty\tT-0\nqueens\tT-0\nare\tO\nhigh-profile\tO\npersonalities\tT-1\nin\tO\nVenezuela\tB-LOC\nand\tO\nMachado\tO\n's\tO\nalleged\tT-2\nweight\tT-2\nproblem\tO\nmade\tO\nfront\tO\npage\tO\nnews\tO\nthis\tO\nweek\tO\n.\tO\n\nBeauty\tO\nqueens\tO\nare\tO\nhigh-profile\tO\npersonalities\tO\nin\tO\nVenezuela\tT-0\nand\tO\nMachado\tB-PER\n's\tO\nalleged\tT-1\nweight\tO\nproblem\tO\nmade\tO\nfront\tO\npage\tO\nnews\tO\nthis\tO\nweek\tO\n.\tO\n\nIt\tO\nwas\tT-1\nan\tO\nofficial\tT-0\nof\tO\nthe\tO\nMiss\tB-ORG\nVenezuela\tI-ORG\nOrganisation\tI-ORG\nwho\tO\nfirst\tO\nsaid\tO\nMachado\tO\nhad\tO\nbeen\tO\ntold\tO\nto\tO\nlose\tO\nweight\tO\nfast\tO\n.\tO\n\nIt\tO\nwas\tO\nan\tO\nofficial\tO\nof\tO\nthe\tO\nMiss\tT-0\nVenezuela\tT-0\nOrganisation\tT-0\nwho\tO\nfirst\tO\nsaid\tT-1\nMachado\tB-PER\nhad\tT-2\nbeen\tT-2\ntold\tO\nto\tO\nlose\tO\nweight\tO\nfast\tO\n.\tO\n\nMartin\tB-PER\nBrooks\tI-PER\n,\tO\npresident\tT-0\nof\tO\nMiss\tO\nUniverse\tO\nInc\tO\n,\tO\nsaid\tT-2\nhe\tO\nspoke\tO\nwith\tO\nMachado\tO\nto\tO\nassure\tO\nher\tO\nthat\tO\norganisers\tO\nwere\tO\nnot\tO\nputting\tO\npressure\tT-1\non\tO\nher\tO\n.\tO\n\nMartin\tT-1\nBrooks\tT-1\n,\tO\npresident\tT-0\nof\tO\nMiss\tB-ORG\nUniverse\tI-ORG\nInc\tI-ORG\n,\tO\nsaid\tO\nhe\tO\nspoke\tO\nwith\tO\nMachado\tO\nto\tO\nassure\tO\nher\tO\nthat\tO\norganisers\tO\nwere\tO\nnot\tO\nputting\tO\npressure\tO\non\tO\nher\tO\n.\tO\n\nMartin\tO\nBrooks\tO\n,\tO\npresident\tT-0\nof\tO\nMiss\tO\nUniverse\tO\nInc\tO\n,\tO\nsaid\tT-1\nhe\tO\nspoke\tO\nwith\tO\nMachado\tB-PER\nto\tO\nassure\tO\nher\tO\nthat\tO\norganisers\tO\nwere\tO\nnot\tO\nputting\tT-2\npressure\tT-2\non\tO\nher\tO\n.\tO\n\nHe\tO\nsaid\tT-1\nthe\tO\nlifestyle\tO\nassociated\tO\nwith\tO\nbeing\tO\nMiss\tB-MISC\nUniverse\tI-MISC\ncould\tO\nmake\tO\nroutine\tO\nexercise\tT-0\ndifficult\tT-2\n.\tO\n\nI\tT-0\ndont\tT-1\nknow\tT-1\nif\tO\nAlicia\tB-PER\nis\tO\nworking\tO\nout\tO\n.\tO\n\nKevorkian\tB-PER\nattends\tT-0\nthird\tO\nsuicide\tO\nin\tO\nweek\tO\n.\tO\n\nPONTIAC\tB-LOC\n,\tO\nMich\tT-0\n.\tO\n\nPONTIAC\tT-0\n,\tO\nMich\tB-LOC\n.\tO\n\nDr.\tT-0\nJack\tB-PER\nKevorkian\tI-PER\nattended\tT-2\nhis\tO\nthird\tO\nsuicide\tT-4\nin\tO\nless\tO\nthan\tO\na\tO\nweek\tO\non\tO\nThursday\tO\n,\tO\nbringing\tT-3\nthe\tO\nbody\tO\nof\tO\na\tO\n40-year-old\tO\nMissouri\tT-1\nwoman\tT-1\nsuffering\tO\nfrom\tO\nmultiple\tO\nsclerosis\tO\nto\tO\na\tO\nhospital\tO\nemergency\tO\nroom\tO\n,\tO\ndoctors\tO\nsaid\tO\n.\tT-0\n\nDr.\tO\nJack\tO\nKevorkian\tO\nattended\tO\nhis\tO\nthird\tO\nsuicide\tO\nin\tO\nless\tO\nthan\tO\na\tO\nweek\tO\non\tO\nThursday\tO\n,\tO\nbringing\tO\nthe\tO\nbody\tO\nof\tO\na\tO\n40-year-old\tO\nMissouri\tB-LOC\nwoman\tO\nsuffering\tT-1\nfrom\tO\nmultiple\tO\nsclerosis\tO\nto\tO\na\tO\nhospital\tT-0\nemergency\tT-0\nroom\tT-0\n,\tO\ndoctors\tO\nsaid\tT-2\n.\tO\n\nDr\tT-0\nRobert\tB-PER\nAranosian\tI-PER\n,\tO\nemergency\tT-1\nroom\tO\ndirector\tO\nat\tO\nPontiac\tO\nOsteopathic\tO\nHospital\tO\n,\tO\nsaid\tO\nKevorkian\tO\nbrought\tO\nin\tO\nthe\tO\nbody\tO\nof\tO\nPatricia\tO\nSmith\tO\n,\tO\nof\tO\nLees\tO\nSummit\tO\n,\tO\nMo\tO\n.\tO\n\nDr\tO\nRobert\tO\nAranosian\tO\n,\tO\nemergency\tT-0\nroom\tT-0\ndirector\tO\nat\tO\nPontiac\tB-LOC\nOsteopathic\tI-LOC\nHospital\tI-LOC\n,\tO\nsaid\tO\nKevorkian\tO\nbrought\tO\nin\tO\nthe\tO\nbody\tO\nof\tO\nPatricia\tO\nSmith\tO\n,\tO\nof\tO\nLees\tT-1\nSummit\tT-1\n,\tT-1\nMo\tT-1\n.\tO\n\nDr\tT-2\nRobert\tT-2\nAranosian\tO\n,\tO\nemergency\tO\nroom\tO\ndirector\tO\nat\tO\nPontiac\tO\nOsteopathic\tO\nHospital\tO\n,\tO\nsaid\tT-1\nKevorkian\tB-PER\nbrought\tT-0\nin\tO\nthe\tO\nbody\tO\nof\tO\nPatricia\tT-3\nSmith\tT-3\n,\tO\nof\tO\nLees\tO\nSummit\tO\n,\tO\nMo\tO\n.\tO\n\nDr\tO\nRobert\tO\nAranosian\tO\n,\tO\nemergency\tO\nroom\tO\ndirector\tO\nat\tO\nPontiac\tO\nOsteopathic\tO\nHospital\tO\n,\tO\nsaid\tO\nKevorkian\tO\nbrought\tO\nin\tO\nthe\tO\nbody\tT-2\nof\tO\nPatricia\tB-PER\nSmith\tI-PER\n,\tO\nof\tO\nLees\tT-0\nSummit\tT-0\n,\tO\nMo\tT-1\n.\tT-1\n\nDr\tO\nRobert\tO\nAranosian\tO\n,\tO\nemergency\tO\nroom\tO\ndirector\tT-0\nat\tO\nPontiac\tO\nOsteopathic\tO\nHospital\tO\n,\tO\nsaid\tT-1\nKevorkian\tO\nbrought\tO\nin\tO\nthe\tO\nbody\tO\nof\tO\nPatricia\tO\nSmith\tO\n,\tO\nof\tO\nLees\tB-LOC\nSummit\tI-LOC\n,\tO\nMo\tO\n.\tO\n\nDr\tT-0\nRobert\tT-0\nAranosian\tT-0\n,\tO\nemergency\tO\nroom\tO\ndirector\tO\nat\tO\nPontiac\tO\nOsteopathic\tO\nHospital\tT-2\n,\tO\nsaid\tO\nKevorkian\tT-1\nbrought\tO\nin\tO\nthe\tO\nbody\tO\nof\tO\nPatricia\tO\nSmith\tO\n,\tO\nof\tO\nLees\tO\nSummit\tO\n,\tO\nMo\tB-LOC\n.\tO\n\nKevorkian\tB-PER\n's\tO\nlawyer\tT-1\n,\tO\nGeoffrey\tT-0\nFieger\tT-0\n,\tO\nsaid\tO\nthose\tO\nattending\tO\nSmith\tO\n's\tO\ndeath\tO\nincluded\tO\nher\tO\nhusband\tO\n,\tO\nDavid\tO\n,\tO\na\tO\npolice\tO\nofficer\tO\n,\tO\nher\tO\nfather\tO\n,\tO\nJames\tO\nPoland\tO\n,\tO\nand\tO\nKevorkian\tO\n.\tO\n\nKevorkian\tO\n's\tO\nlawyer\tT-0\n,\tO\nGeoffrey\tB-PER\nFieger\tI-PER\n,\tO\nsaid\tO\nthose\tO\nattending\tO\nSmith\tO\n's\tO\ndeath\tO\nincluded\tO\nher\tO\nhusband\tO\n,\tO\nDavid\tO\n,\tO\na\tO\npolice\tO\nofficer\tT-1\n,\tO\nher\tO\nfather\tO\n,\tO\nJames\tO\nPoland\tO\n,\tO\nand\tO\nKevorkian\tO\n.\tO\n\nKevorkian\tT-2\n's\tO\nlawyer\tO\n,\tO\nGeoffrey\tT-3\nFieger\tT-3\n,\tO\nsaid\tO\nthose\tT-0\nattending\tT-4\nSmith\tB-PER\n's\tT-1\ndeath\tT-1\nincluded\tO\nher\tO\nhusband\tO\n,\tO\nDavid\tO\n,\tO\na\tO\npolice\tO\nofficer\tO\n,\tO\nher\tO\nfather\tO\n,\tO\nJames\tO\nPoland\tO\n,\tO\nand\tO\nKevorkian\tO\n.\tO\n\nKevorkian\tO\n's\tO\nlawyer\tO\n,\tO\nGeoffrey\tO\nFieger\tO\n,\tO\nsaid\tO\nthose\tO\nattending\tO\nSmith\tO\n's\tO\ndeath\tO\nincluded\tO\nher\tO\nhusband\tO\n,\tO\nDavid\tB-PER\n,\tO\na\tT-1\npolice\tO\nofficer\tO\n,\tO\nher\tO\nfather\tO\n,\tO\nJames\tT-0\nPoland\tT-0\n,\tO\nand\tO\nKevorkian\tO\n.\tO\n\nKevorkian\tO\n's\tO\nlawyer\tO\n,\tO\nGeoffrey\tO\nFieger\tO\n,\tO\nsaid\tO\nthose\tO\nattending\tO\nSmith\tO\n's\tO\ndeath\tO\nincluded\tO\nher\tO\nhusband\tO\n,\tO\nDavid\tO\n,\tO\na\tO\npolice\tO\nofficer\tO\n,\tO\nher\tO\nfather\tT-0\n,\tO\nJames\tB-PER\nPoland\tI-PER\n,\tO\nand\tO\nKevorkian\tT-1\n.\tO\n\nKevorkian\tO\n's\tO\nlawyer\tT-0\n,\tO\nGeoffrey\tO\nFieger\tO\n,\tO\nsaid\tO\nthose\tO\nattending\tO\nSmith\tO\n's\tO\ndeath\tO\nincluded\tO\nher\tO\nhusband\tT-2\n,\tO\nDavid\tO\n,\tO\na\tO\npolice\tO\nofficer\tO\n,\tO\nher\tO\nfather\tT-3\n,\tO\nJames\tO\nPoland\tO\n,\tO\nand\tT-1\nKevorkian\tB-PER\n.\tO\n\nIt\tO\nwas\tO\nthe\tO\nfirst\tO\nknown\tT-2\ntime\tO\nthat\tO\na\tO\npolice\tO\nofficer\tO\nhas\tO\nbeen\tO\npresident\tT-0\nat\tO\nthe\tO\nsuicide\tO\nof\tO\none\tO\nof\tO\nKevorkian\tB-PER\n's\tO\npatients\tT-1\n.\tO\n\nHe\tO\noffered\tT-1\nno\tO\ndetails\tO\nabout\tO\nthe\tO\ncause\tT-2\nof\tO\nSmith\tB-PER\n's\tO\ndeath\tT-0\nor\tO\nthe\tO\nlocation\tT-3\n.\tO\n\nOn\tO\nTuesday\tO\nnight\tO\n,\tO\nKevorkian\tB-PER\nattended\tT-0\nthe\tO\ndeath\tO\nof\tO\nLouise\tT-1\nSiebens\tT-1\n,\tO\na\tO\n76-year-old\tO\nTexas\tO\nwoman\tO\nwith\tO\namyotrophic\tO\nlateral\tO\nsclerosis\tO\n,\tO\nor\tO\nLou\tO\nGehrig\tO\n's\tO\ndisease\tO\n.\tO\n\nOn\tO\nTuesday\tO\nnight\tO\n,\tO\nKevorkian\tO\nattended\tO\nthe\tO\ndeath\tO\nof\tO\nLouise\tB-PER\nSiebens\tI-PER\n,\tO\na\tO\n76-year-old\tT-1\nTexas\tT-1\nwoman\tT-1\nwith\tO\namyotrophic\tT-2\nlateral\tT-2\nsclerosis\tT-2\n,\tO\nor\tO\nLou\tO\nGehrig\tO\n's\tO\ndisease\tT-0\n.\tO\n\nOn\tO\nTuesday\tO\nnight\tO\n,\tO\nKevorkian\tT-0\nattended\tT-2\nthe\tO\ndeath\tO\nof\tO\nLouise\tT-1\nSiebens\tT-1\n,\tO\na\tO\n76-year-old\tO\nTexas\tB-LOC\nwoman\tO\nwith\tO\namyotrophic\tO\nlateral\tO\nsclerosis\tO\n,\tO\nor\tO\nLou\tO\nGehrig\tO\n's\tO\ndisease\tO\n.\tO\n\nOn\tO\nTuesday\tO\nnight\tO\n,\tO\nKevorkian\tT-0\nattended\tO\nthe\tO\ndeath\tO\nof\tO\nLouise\tO\nSiebens\tO\n,\tO\na\tO\n76-year-old\tO\nTexas\tO\nwoman\tO\nwith\tO\namyotrophic\tO\nlateral\tT-1\nsclerosis\tT-1\n,\tO\nor\tO\nLou\tB-PER\nGehrig\tI-PER\n's\tT-2\ndisease\tT-2\n.\tO\n\nOn\tO\nAugust\tO\n15\tO\n,\tO\nKevorkian\tB-PER\nhelped\tO\nJudith\tO\nCurren\tO\n,\tO\na\tO\n42-year-old\tO\nMassachusetts\tO\nnurse\tT-1\n,\tO\nwho\tO\nsuffered\tO\nfrom\tO\nchronic\tT-2\nfatigue\tT-2\nsyndrome\tT-2\n,\tO\na\tO\nnon-terminal\tO\nillness\tO\n,\tO\nto\tT-0\nend\tT-0\nher\tT-0\nlife\tT-0\n.\tO\n\nOn\tO\nAugust\tO\n15\tO\n,\tO\nKevorkian\tT-4\nhelped\tT-0\nJudith\tB-PER\nCurren\tI-PER\n,\tO\na\tO\n42-year-old\tT-2\nMassachusetts\tT-2\nnurse\tT-2\n,\tO\nwho\tO\nsuffered\tT-3\nfrom\tT-3\nchronic\tT-3\nfatigue\tT-3\nsyndrome\tT-3\n,\tO\na\tO\nnon-terminal\tO\nillness\tO\n,\tO\nto\tO\nend\tO\nher\tT-1\nlife\tO\n.\tO\n\nOn\tO\nAugust\tO\n15\tO\n,\tO\nKevorkian\tO\nhelped\tO\nJudith\tO\nCurren\tO\n,\tO\na\tO\n42-year-old\tO\nMassachusetts\tB-LOC\nnurse\tT-1\n,\tO\nwho\tO\nsuffered\tT-0\nfrom\tO\nchronic\tO\nfatigue\tO\nsyndrome\tO\n,\tO\na\tO\nnon-terminal\tO\nillness\tO\n,\tO\nto\tO\nend\tO\nher\tO\nlife\tO\n.\tO\n\nFairview\tB-LOC\n,\tO\nTexas\tT-2\n,\tO\n$\tO\n1.82\tO\nmillion\tO\ndeal\tT-0\nBaa1\tO\n-\tO\nMoody\tT-1\n's\tO\n.\tO\n\nFairview\tO\n,\tO\nTexas\tB-LOC\n,\tO\n$\tO\n1.82\tO\nmillion\tO\ndeal\tT-2\nBaa1\tT-1\n-\tO\nMoody\tT-0\n's\tO\n.\tO\n\nFairview\tT-0\n,\tO\nTexas\tO\n,\tO\n$\tT-1\n1.82\tT-1\nmillion\tT-1\ndeal\tT-1\nBaa1\tO\n-\tO\nMoody\tB-ORG\n's\tI-ORG\n.\tO\n\nIssuer\tT-0\n:\tO\nFairview\tB-LOC\nTown\tI-LOC\n\nState\tT-0\n:\tT-0\nTX\tB-LOC\n\nDefiant\tT-1\nU.S.\tB-LOC\nneo-Nazi\tO\njailed\tT-0\nby\tO\nGerman\tO\ncourt\tO\n.\tO\n\nHAMBURG\tB-LOC\n,\tO\nGermany\tT-0\n1996-08-22\tO\n\nHAMBURG\tT-0\n,\tO\nGermany\tB-LOC\n1996-08-22\tT-1\n\nA\tO\nHamburg\tB-LOC\ncourt\tO\nsentenced\tT-1\nU.S.\tT-0\nneo-Nazi\tO\nleader\tO\nGary\tO\nLauck\tO\non\tO\nThursday\tO\nto\tO\nfour\tO\nyears\tO\nin\tO\nprison\tO\nfor\tO\npumping\tO\nbanned\tT-2\nextremist\tO\npropaganda\tO\ninto\tO\nGermany\tT-3\nfrom\tO\nhis\tO\nbase\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tT-0\n\nA\tO\nHamburg\tT-1\ncourt\tO\nsentenced\tT-0\nU.S.\tB-LOC\nneo-Nazi\tO\nleader\tO\nGary\tO\nLauck\tO\non\tO\nThursday\tO\nto\tO\nfour\tO\nyears\tO\nin\tO\nprison\tO\nfor\tO\npumping\tO\nbanned\tO\nextremist\tO\npropaganda\tO\ninto\tO\nGermany\tO\nfrom\tO\nhis\tO\nbase\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tO\n\nA\tO\nHamburg\tO\ncourt\tT-0\nsentenced\tO\nU.S.\tT-2\nneo-Nazi\tB-MISC\nleader\tT-3\nGary\tT-3\nLauck\tO\non\tO\nThursday\tO\nto\tO\nfour\tO\nyears\tO\nin\tO\nprison\tO\nfor\tO\npumping\tO\nbanned\tO\nextremist\tO\npropaganda\tO\ninto\tO\nGermany\tO\nfrom\tO\nhis\tO\nbase\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tO\n\nA\tO\nHamburg\tO\ncourt\tO\nsentenced\tT-1\nU.S.\tO\nneo-Nazi\tO\nleader\tO\nGary\tB-PER\nLauck\tI-PER\non\tO\nThursday\tO\nto\tO\nfour\tO\nyears\tO\nin\tO\nprison\tT-0\nfor\tO\npumping\tO\nbanned\tO\nextremist\tO\npropaganda\tO\ninto\tO\nGermany\tO\nfrom\tO\nhis\tO\nbase\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tO\n\nA\tO\nHamburg\tO\ncourt\tO\nsentenced\tT-1\nU.S.\tO\nneo-Nazi\tO\nleader\tO\nGary\tO\nLauck\tO\non\tO\nThursday\tO\nto\tO\nfour\tO\nyears\tO\nin\tO\nprison\tO\nfor\tO\npumping\tO\nbanned\tT-2\nextremist\tO\npropaganda\tO\ninto\tT-0\nGermany\tB-LOC\nfrom\tO\nhis\tO\nbase\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tO\n\nA\tO\nHamburg\tT-0\ncourt\tO\nsentenced\tO\nU.S.\tT-1\nneo-Nazi\tO\nleader\tO\nGary\tT-2\nLauck\tT-2\non\tO\nThursday\tO\nto\tO\nfour\tO\nyears\tO\nin\tO\nprison\tO\nfor\tO\npumping\tO\nbanned\tO\nextremist\tO\npropaganda\tT-4\ninto\tO\nGermany\tO\nfrom\tO\nhis\tO\nbase\tT-3\nin\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\n.\tO\n\nLauck\tB-PER\n,\tO\nfrom\tO\nLincoln\tT-0\n,\tT-0\nNebraska\tT-0\n,\tO\nyelled\tO\na\tO\ntirade\tO\nof\tO\nabuse\tO\nat\tO\nthe\tO\ncourt\tO\nafter\tO\nhis\tO\nconviction\tT-1\nfor\tO\ninciting\tO\nracial\tO\nhatred\tO\n.\tO\n\nLauck\tT-1\n,\tT-1\nfrom\tT-1\nLincoln\tB-LOC\n,\tO\nNebraska\tT-2\n,\tO\nyelled\tO\na\tO\ntirade\tO\nof\tO\nabuse\tO\nat\tO\nthe\tO\ncourt\tO\nafter\tO\nhis\tO\nconviction\tO\nfor\tO\ninciting\tO\nracial\tT-0\nhatred\tT-0\n.\tO\n\nLauck\tO\n,\tO\nfrom\tO\nLincoln\tT-1\n,\tO\nNebraska\tB-LOC\n,\tO\nyelled\tO\na\tO\ntirade\tO\nof\tO\nabuse\tO\nat\tO\nthe\tO\ncourt\tO\nafter\tO\nhis\tO\nconviction\tO\nfor\tO\ninciting\tO\nracial\tO\nhatred\tT-0\n.\tO\n\n\"\tO\nThe\tO\nstruggle\tT-2\nwill\tO\ngo\tO\non\tO\n,\tO\n\"\tO\nthe\tO\n43-year-old\tO\nshouted\tO\nin\tT-1\nGerman\tB-MISC\nbefore\tO\nbeing\tO\nescorted\tO\nout\tO\nby\tO\nsecurity\tT-0\nguards\tT-0\n.\tO\n\nLauck\tB-PER\n's\tT-5\nlawyer\tT-5\nvowed\tT-0\nhe\tO\nwould\tO\nappeal\tT-1\nagainst\tO\nthe\tO\ncourt\tO\n's\tO\ndecision\tO\n,\tO\narguing\tT-2\nthat\tO\nhis\tO\nclient\tO\nshould\tO\nhave\tO\nbeen\tO\nset\tO\nfree\tO\nbecause\tO\nhe\tO\nhad\tO\nnot\tO\ncommitted\tO\nany\tO\noffence\tO\nunder\tO\nGerman\tO\nlaw\tO\n.\tT-4\n\nLauck\tO\n's\tO\nlawyer\tT-2\nvowed\tT-0\nhe\tO\nwould\tO\nappeal\tT-3\nagainst\tO\nthe\tO\ncourt\tO\n's\tO\ndecision\tO\n,\tO\narguing\tO\nthat\tO\nhis\tO\nclient\tO\nshould\tO\nhave\tO\nbeen\tO\nset\tO\nfree\tO\nbecause\tO\nhe\tO\nhad\tO\nnot\tO\ncommitted\tO\nany\tO\noffence\tO\nunder\tO\nGerman\tB-MISC\nlaw\tT-1\n.\tO\n\nThe\tO\nGerman\tB-MISC\ngovernment\tT-3\nhailed\tT-2\nthe\tO\nconviction\tT-0\nas\tO\na\tO\nmajor\tO\nvictory\tO\nin\tO\nthe\tO\nfight\tO\nagainst\tO\nneo-Nazism\tT-1\n.\tO\n\nThe\tO\nGerman\tT-1\ngovernment\tT-1\nhailed\tT-2\nthe\tO\nconviction\tO\nas\tO\na\tO\nmajor\tO\nvictory\tT-3\nin\tO\nthe\tO\nfight\tO\nagainst\tT-0\nneo-Nazism\tB-MISC\n.\tO\n\nLauck\tB-PER\n's\tO\nworldwide\tO\nnetwork\tO\nhas\tO\nbeen\tO\nthe\tO\nmain\tO\nsource\tT-0\nof\tO\nanti-Semitic\tO\npropaganda\tO\nmaterial\tO\nflowing\tO\ninto\tO\nGermany\tO\nsince\tO\nthe\tO\n1970s\tO\n.\tO\n\nLauck\tT-2\n's\tO\nworldwide\tO\nnetwork\tT-0\nhas\tO\nbeen\tO\nthe\tO\nmain\tO\nsource\tO\nof\tO\nanti-Semitic\tB-MISC\npropaganda\tT-3\nmaterial\tO\nflowing\tO\ninto\tO\nGermany\tT-1\nsince\tO\nthe\tO\n1970s\tO\n.\tO\n\nLauck\tO\n's\tO\nworldwide\tT-0\nnetwork\tO\nhas\tO\nbeen\tO\nthe\tO\nmain\tO\nsource\tO\nof\tO\nanti-Semitic\tO\npropaganda\tO\nmaterial\tO\nflowing\tT-1\ninto\tO\nGermany\tB-LOC\nsince\tO\nthe\tO\n1970s\tO\n.\tO\n\n\"\tO\nLauck\tB-PER\npossessed\tO\na\tO\nwell-oiled\tO\npropaganda\tT-2\nmachine\tT-2\n,\tO\nhoned\tO\nduring\tT-0\nmore\tO\nthan\tO\n20\tO\nyears\tO\n,\tO\n\"\tO\npresiding\tO\njudge\tO\nGuenter\tO\nBertram\tO\ntold\tT-1\nthe\tO\ncourt\tO\n.\tO\n\n\"\tO\nLauck\tO\npossessed\tO\na\tO\nwell-oiled\tO\npropaganda\tO\nmachine\tO\n,\tO\nhoned\tO\nduring\tO\nmore\tO\nthan\tO\n20\tO\nyears\tO\n,\tO\n\"\tO\npresiding\tT-0\njudge\tT-2\nGuenter\tB-PER\nBertram\tI-PER\ntold\tT-1\nthe\tO\ncourt\tO\n.\tO\n\n\"\tO\nHe\tO\nset\tO\nup\tO\na\tO\npropaganda\tT-1\ncannon\tT-1\nand\tO\nfired\tO\nit\tO\nat\tT-0\nGermany\tB-LOC\n.\tO\n\"\tO\n\nsaid\tT-3\nBertram\tB-PER\n,\tO\nwho\tO\nalso\tO\nread\tO\nout\tO\nextracts\tO\nfrom\tO\nLauck\tT-0\n's\tT-0\nmaterial\tT-0\npraising\tT-1\nHitler\tT-2\nas\tO\n\"\tO\nthe\tO\ngreatest\tO\nof\tO\nall\tO\nleaders\tO\n\"\tO\nand\tO\ndescribing\tO\nthe\tO\nNazi\tO\nslaughter\tO\nof\tO\nmillions\tO\nof\tO\nJews\tO\nas\tO\na\tO\nmyth\tO\n.\tO\n\nsaid\tO\nBertram\tO\n,\tO\nwho\tO\nalso\tO\nread\tO\nout\tO\nextracts\tO\nfrom\tO\nLauck\tB-PER\n's\tO\nmaterial\tT-0\npraising\tT-1\nHitler\tO\nas\tO\n\"\tO\nthe\tO\ngreatest\tO\nof\tO\nall\tO\nleaders\tO\n\"\tO\nand\tO\ndescribing\tO\nthe\tO\nNazi\tO\nslaughter\tO\nof\tO\nmillions\tO\nof\tO\nJews\tO\nas\tO\na\tO\nmyth\tO\n.\tO\n\nsaid\tT-1\nBertram\tO\n,\tO\nwho\tO\nalso\tO\nread\tT-2\nout\tO\nextracts\tO\nfrom\tO\nLauck\tO\n's\tO\nmaterial\tO\npraising\tT-3\nHitler\tB-PER\nas\tO\n\"\tO\nthe\tO\ngreatest\tT-0\nof\tT-0\nall\tT-0\nleaders\tT-0\n\"\tO\nand\tO\ndescribing\tT-4\nthe\tO\nNazi\tO\nslaughter\tO\nof\tO\nmillions\tO\nof\tO\nJews\tO\nas\tO\na\tO\nmyth\tO\n.\tO\n\nsaid\tO\nBertram\tO\n,\tO\nwho\tO\nalso\tO\nread\tT-2\nout\tO\nextracts\tO\nfrom\tO\nLauck\tO\n's\tO\nmaterial\tO\npraising\tO\nHitler\tT-0\nas\tO\n\"\tO\nthe\tO\ngreatest\tO\nof\tO\nall\tO\nleaders\tO\n\"\tO\nand\tO\ndescribing\tO\nthe\tO\nNazi\tB-MISC\nslaughter\tO\nof\tO\nmillions\tO\nof\tO\nJews\tT-1\nas\tO\na\tO\nmyth\tO\n.\tO\n\nsaid\tO\nBertram\tO\n,\tO\nwho\tO\nalso\tO\nread\tO\nout\tO\nextracts\tO\nfrom\tO\nLauck\tO\n's\tO\nmaterial\tO\npraising\tO\nHitler\tO\nas\tO\n\"\tO\nthe\tO\ngreatest\tO\nof\tO\nall\tO\nleaders\tO\n\"\tO\nand\tO\ndescribing\tO\nthe\tO\nNazi\tO\nslaughter\tT-1\nof\tO\nmillions\tT-0\nof\tO\nJews\tB-MISC\nas\tO\na\tO\nmyth\tO\n.\tO\n\nEager\tO\nto\tO\nput\tO\nLauck\tB-PER\nbehind\tT-0\nbars\tT-0\nquickly\tT-3\nand\tO\navoid\tO\na\tO\nlong\tO\nand\tO\ncomplex\tO\ntrial\tO\n,\tO\nprosecutor\tT-1\nBernd\tT-1\nMauruschat\tT-1\nlimited\tT-2\nhis\tO\ncharges\tO\nto\tO\noffences\tO\nsince\tO\n1994\tO\n.\tO\n\nEager\tO\nto\tO\nput\tO\nLauck\tT-0\nbehind\tO\nbars\tO\nquickly\tO\nand\tO\navoid\tO\na\tO\nlong\tO\nand\tO\ncomplex\tO\ntrial\tO\n,\tO\nprosecutor\tO\nBernd\tB-PER\nMauruschat\tI-PER\nlimited\tT-1\nhis\tO\ncharges\tT-2\nto\tO\noffences\tO\nsince\tO\n1994\tO\n.\tO\n\nPublishing\tT-3\nand\tO\ndistributing\tT-4\nneo-Nazi\tB-MISC\nmaterial\tT-0\nis\tO\nillegal\tO\nin\tO\nGermany\tT-1\nbut\tO\nLauck\tT-2\n's\tO\ndefence\tO\nteam\tO\nhad\tO\nargued\tO\nthat\tO\nU.S\tO\nfreedom\tO\nof\tO\nspeech\tO\nlaws\tO\nmeant\tO\nhe\tO\nwas\tO\nfree\tO\nto\tO\nproduce\tO\nhis\tO\nswastika-covered\tO\nbooks\tO\n,\tO\nmagazines\tO\n,\tO\nvideos\tO\nand\tO\nflags\tO\nin\tO\nhis\tO\nhomeland\tO\n.\tO\n\nPublishing\tO\nand\tO\ndistributing\tO\nneo-Nazi\tT-0\nmaterial\tT-0\nis\tO\nillegal\tO\nin\tT-2\nGermany\tB-LOC\nbut\tO\nLauck\tT-1\n's\tT-1\ndefence\tT-1\nteam\tO\nhad\tO\nargued\tO\nthat\tO\nU.S\tO\nfreedom\tO\nof\tO\nspeech\tO\nlaws\tO\nmeant\tO\nhe\tO\nwas\tO\nfree\tO\nto\tO\nproduce\tO\nhis\tO\nswastika-covered\tO\nbooks\tO\n,\tO\nmagazines\tO\n,\tO\nvideos\tO\nand\tO\nflags\tO\nin\tO\nhis\tT-3\nhomeland\tT-3\n.\tO\n\nPublishing\tO\nand\tO\ndistributing\tO\nneo-Nazi\tT-2\nmaterial\tT-2\nis\tO\nillegal\tO\nin\tO\nGermany\tO\nbut\tT-1\nLauck\tB-PER\n's\tO\ndefence\tO\nteam\tO\nhad\tO\nargued\tO\nthat\tO\nU.S\tO\nfreedom\tO\nof\tO\nspeech\tO\nlaws\tO\nmeant\tO\nhe\tO\nwas\tO\nfree\tO\nto\tO\nproduce\tO\nhis\tO\nswastika-covered\tT-0\nbooks\tO\n,\tO\nmagazines\tO\n,\tO\nvideos\tO\nand\tO\nflags\tO\nin\tO\nhis\tO\nhomeland\tO\n.\tT-0\n\nPublishing\tO\nand\tO\ndistributing\tO\nneo-Nazi\tO\nmaterial\tO\nis\tO\nillegal\tO\nin\tO\nGermany\tT-0\nbut\tO\nLauck\tO\n's\tO\ndefence\tO\nteam\tO\nhad\tO\nargued\tO\nthat\tO\nU.S\tB-LOC\nfreedom\tO\nof\tO\nspeech\tO\nlaws\tO\nmeant\tO\nhe\tO\nwas\tO\nfree\tO\nto\tO\nproduce\tO\nhis\tO\nswastika-covered\tO\nbooks\tO\n,\tO\nmagazines\tO\n,\tO\nvideos\tO\nand\tO\nflags\tO\nin\tT-1\nhis\tT-1\nhomeland\tT-1\n.\tO\n\nInterior\tT-1\nMinister\tT-1\nManfred\tB-PER\nKanther\tI-PER\nsaid\tT-0\nin\tO\na\tO\nstatement\tO\nhe\tO\n\"\tO\nwelcomed\tO\nthe\tO\nprosecution\tO\nand\tO\nconviction\tO\nof\tO\none\tO\nof\tO\nthe\tO\nringleaders\tO\nof\tO\ninternational\tO\nneo-Nazism\tO\nand\tO\nbiggest\tO\ndistributers\tO\nof\tO\nvicious\tO\nracist\tO\npublications\tO\n\"\tO\n.\tO\n\nInterior\tO\nMinister\tO\nManfred\tO\nKanther\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\nhe\tO\n\"\tO\nwelcomed\tT-2\nthe\tO\nprosecution\tO\nand\tO\nconviction\tO\nof\tO\none\tO\nof\tO\nthe\tO\nringleaders\tO\nof\tO\ninternational\tT-0\nneo-Nazism\tB-MISC\nand\tO\nbiggest\tO\ndistributers\tT-1\nof\tO\nvicious\tO\nracist\tO\npublications\tO\n\"\tO\n.\tO\n\n\"\tO\nIt\tO\nis\tO\nhigh\tO\ntime\tO\nhe\tO\nwas\tO\nbehind\tT-1\nbars\tO\n,\tO\n\"\tO\nthe\tO\nopposition\tO\nSocial\tB-MISC\nDemocrats\tI-MISC\nsaid\tT-0\nin\tO\na\tO\nstatement\tO\n.\tO\n\nLauck\tB-PER\n,\tO\ndressed\tO\nin\tO\na\tO\nsober\tO\nblue\tO\nsuit\tO\nand\tO\nsporting\tO\nhis\tO\ntrademark\tT-0\nHitleresque\tO\nblack\tO\nmoustache\tO\n,\tO\nshowed\tO\nno\tO\nsign\tO\nof\tO\nemotion\tO\nas\tO\nBertram\tO\nspent\tO\nmore\tO\nthan\tO\nan\tO\nhour\tO\nreading\tO\nout\tO\nthe\tO\nverdict\tO\nand\tO\nexplaining\tO\nthe\tO\ncourt\tT-1\n's\tO\ndecision\tO\n.\tO\n\nLauck\tT-2\n,\tO\ndressed\tT-0\nin\tO\na\tO\nsober\tO\nblue\tT-3\nsuit\tT-3\nand\tO\nsporting\tO\nhis\tO\ntrademark\tT-1\nHitleresque\tB-MISC\nblack\tT-4\nmoustache\tT-4\n,\tO\nshowed\tO\nno\tO\nsign\tO\nof\tO\nemotion\tO\nas\tO\nBertram\tO\nspent\tO\nmore\tO\nthan\tO\nan\tO\nhour\tO\nreading\tO\nout\tO\nthe\tO\nverdict\tO\nand\tO\nexplaining\tO\nthe\tO\ncourt\tO\n's\tO\ndecision\tO\n.\tO\n\nLauck\tT-1\n,\tO\ndressed\tO\nin\tO\na\tO\nsober\tO\nblue\tT-0\nsuit\tT-0\nand\tO\nsporting\tO\nhis\tO\ntrademark\tO\nHitleresque\tO\nblack\tO\nmoustache\tO\n,\tO\nshowed\tO\nno\tO\nsign\tO\nof\tO\nemotion\tO\nas\tO\nBertram\tB-PER\nspent\tT-3\nmore\tO\nthan\tO\nan\tO\nhour\tO\nreading\tT-4\nout\tO\nthe\tO\nverdict\tO\nand\tO\nexplaining\tT-5\nthe\tO\ncourt\tO\n's\tO\ndecision\tT-2\n.\tO\n\nBut\tO\nas\tO\nLauck\tB-PER\nwas\tO\nabout\tO\nto\tO\nbe\tO\nled\tT-1\naway\tT-1\n,\tO\nhe\tO\nturned\tO\nto\tO\nreporters\tT-0\nand\tO\nblurted\tO\nout\tO\na\tO\nvirtually\tO\nincomprehensible\tO\nquick-fire\tO\ndiatribe\tO\nagainst\tT-2\nthe\tT-2\ncourt\tT-2\n.\tO\n\n\"\tO\nNeither\tT-0\nthe\tT-0\nNational\tB-MISC\nSocialists\tI-MISC\n(\tO\nNazis\tO\n)\tO\nnor\tO\nthe\tO\ncommunists\tO\ndared\tT-1\nto\tT-1\nkidnap\tT-1\nan\tO\nAmerican\tO\ncitizen\tO\n,\tO\n\"\tO\nhe\tO\nshouted\tO\n,\tO\nin\tO\nan\tO\noblique\tO\nreference\tO\nto\tO\nhis\tO\nextradition\tO\nto\tO\nGermany\tO\nfrom\tO\nDenmark\tO\n.\tO\n\"\tO\n\n\"\tO\nNeither\tT-3\nthe\tT-3\nNational\tT-0\nSocialists\tT-0\n(\tO\nNazis\tB-MISC\n)\tO\nnor\tT-2\nthe\tO\ncommunists\tO\ndared\tO\nto\tO\nkidnap\tO\nan\tO\nAmerican\tT-1\ncitizen\tT-1\n,\tO\n\"\tO\nhe\tO\nshouted\tO\n,\tO\nin\tO\nan\tO\noblique\tO\nreference\tO\nto\tO\nhis\tO\nextradition\tO\nto\tO\nGermany\tO\nfrom\tO\nDenmark\tO\n.\tO\n\"\tO\n\n\"\tO\nNeither\tO\nthe\tO\nNational\tO\nSocialists\tO\n(\tO\nNazis\tO\n)\tO\nnor\tO\nthe\tO\ncommunists\tO\ndared\tO\nto\tO\nkidnap\tT-0\nan\tT-0\nAmerican\tB-MISC\ncitizen\tT-1\n,\tO\n\"\tO\nhe\tO\nshouted\tO\n,\tO\nin\tO\nan\tO\noblique\tO\nreference\tO\nto\tO\nhis\tO\nextradition\tT-2\nto\tO\nGermany\tT-3\nfrom\tO\nDenmark\tT-4\n.\tO\n\"\tO\n\n\"\tO\nNeither\tO\nthe\tO\nNational\tT-0\nSocialists\tO\n(\tO\nNazis\tO\n)\tO\nnor\tO\nthe\tO\ncommunists\tO\ndared\tO\nto\tO\nkidnap\tO\nan\tO\nAmerican\tO\ncitizen\tO\n,\tO\n\"\tO\nhe\tO\nshouted\tO\n,\tO\nin\tO\nan\tO\noblique\tO\nreference\tT-1\nto\tO\nhis\tO\nextradition\tO\nto\tO\nGermany\tB-LOC\nfrom\tO\nDenmark\tT-2\n.\tO\n\"\tO\n\n\"\tO\nNeither\tO\nthe\tO\nNational\tT-2\nSocialists\tT-2\n(\tO\nNazis\tO\n)\tO\nnor\tO\nthe\tO\ncommunists\tO\ndared\tO\nto\tO\nkidnap\tO\nan\tO\nAmerican\tO\ncitizen\tO\n,\tO\n\"\tO\nhe\tO\nshouted\tO\n,\tO\nin\tO\nan\tO\noblique\tO\nreference\tO\nto\tO\nhis\tO\nextradition\tT-0\nto\tO\nGermany\tO\nfrom\tT-1\nDenmark\tB-LOC\n.\tO\n\"\tO\n\nHis\tO\nattorney\tO\n,\tO\nHans-Otto\tB-PER\nSieg\tI-PER\n,\tO\ntold\tT-0\nreporters\tO\noutside\tO\nthe\tO\ncourtroom\tO\nthat\tO\nthe\tO\njudges\tO\nhad\tO\nnot\tO\nexplained\tT-1\nhow\tO\na\tO\nGerman\tT-2\ncourt\tO\ncould\tO\njudge\tO\nsomeone\tO\nfor\tO\nactions\tO\ncarried\tO\nout\tO\nin\tO\nthe\tO\nUnited\tT-3\nStates\tT-3\n.\tO\n\nHis\tO\nattorney\tO\n,\tO\nHans-Otto\tO\nSieg\tO\n,\tO\ntold\tO\nreporters\tT-1\noutside\tO\nthe\tO\ncourtroom\tO\nthat\tO\nthe\tO\njudges\tO\nhad\tO\nnot\tO\nexplained\tT-0\nhow\tO\na\tO\nGerman\tB-MISC\ncourt\tO\ncould\tO\njudge\tO\nsomeone\tO\nfor\tO\nactions\tO\ncarried\tO\nout\tO\nin\tO\nthe\tO\nUnited\tO\nStates\tO\n.\tO\n\nHis\tO\nattorney\tO\n,\tO\nHans-Otto\tT-0\nSieg\tT-0\n,\tO\ntold\tO\nreporters\tO\noutside\tO\nthe\tO\ncourtroom\tT-3\nthat\tO\nthe\tO\njudges\tT-1\nhad\tO\nnot\tT-6\nexplained\tT-6\nhow\tT-6\na\tO\nGerman\tT-4\ncourt\tO\ncould\tO\njudge\tT-2\nsomeone\tO\nfor\tO\nactions\tO\ncarried\tT-5\nout\tT-5\nin\tT-5\nthe\tT-5\nUnited\tB-LOC\nStates\tI-LOC\n.\tO\n\nBertram\tB-PER\nsaid\tO\nLauck\tO\nwas\tO\nobsessed\tO\nby\tO\nNazism\tO\nand\tO\ndevoted\tO\nhis\tO\nlife\tO\nto\tO\nleading\tO\nhis\tO\nNational\tO\nSocialist\tO\nGerman\tO\nWorkers\tO\n'\tO\nParty\tO\nForeign\tO\nOrganisation\tO\n(\tO\nNSDAP-AO\tO\n)\tO\n,\tO\nwhich\tO\nderives\tT-0\nits\tO\nname\tO\nfrom\tO\nthe\tO\nfull\tO\nGerman\tT-1\ntitle\tO\nof\tO\nHitler\tO\n's\tO\nNazi\tO\nparty\tO\n.\tO\n\nBertram\tT-2\nsaid\tT-2\nLauck\tB-PER\nwas\tO\nobsessed\tO\nby\tO\nNazism\tT-1\nand\tO\ndevoted\tO\nhis\tO\nlife\tO\nto\tO\nleading\tO\nhis\tO\nNational\tO\nSocialist\tO\nGerman\tO\nWorkers\tO\n'\tO\nParty\tO\nForeign\tO\nOrganisation\tO\n(\tO\nNSDAP-AO\tO\n)\tO\n,\tO\nwhich\tO\nderives\tT-0\nits\tO\nname\tO\nfrom\tO\nthe\tO\nfull\tO\nGerman\tO\ntitle\tO\nof\tO\nHitler\tO\n's\tO\nNazi\tO\nparty\tO\n.\tO\n\nBertram\tO\nsaid\tO\nLauck\tT-0\nwas\tT-0\nobsessed\tT-0\nby\tT-0\nNazism\tB-MISC\nand\tO\ndevoted\tO\nhis\tO\nlife\tO\nto\tO\nleading\tO\nhis\tO\nNational\tO\nSocialist\tO\nGerman\tO\nWorkers\tO\n'\tO\nParty\tO\nForeign\tO\nOrganisation\tO\n(\tO\nNSDAP-AO\tO\n)\tO\n,\tO\nwhich\tO\nderives\tO\nits\tO\nname\tO\nfrom\tO\nthe\tO\nfull\tO\nGerman\tO\ntitle\tO\nof\tO\nHitler\tO\n's\tO\nNazi\tO\nparty\tO\n.\tO\n\nBertram\tT-0\nsaid\tO\nLauck\tO\nwas\tO\nobsessed\tO\nby\tO\nNazism\tO\nand\tO\ndevoted\tO\nhis\tO\nlife\tO\nto\tO\nleading\tO\nhis\tO\nNational\tB-ORG\nSocialist\tI-ORG\nGerman\tI-ORG\nWorkers\tI-ORG\n'\tI-ORG\nParty\tI-ORG\nForeign\tI-ORG\nOrganisation\tI-ORG\n(\tO\nNSDAP-AO\tO\n)\tO\n,\tO\nwhich\tO\nderives\tO\nits\tO\nname\tO\nfrom\tO\nthe\tO\nfull\tO\nGerman\tO\ntitle\tO\nof\tO\nHitler\tO\n's\tO\nNazi\tO\nparty\tO\n.\tO\n\nBertram\tO\nsaid\tT-0\nLauck\tO\nwas\tO\nobsessed\tT-1\nby\tO\nNazism\tT-4\nand\tO\ndevoted\tO\nhis\tO\nlife\tO\nto\tO\nleading\tO\nhis\tO\nNational\tO\nSocialist\tO\nGerman\tO\nWorkers\tO\n'\tO\nParty\tT-2\nForeign\tT-2\nOrganisation\tT-2\n(\tO\nNSDAP-AO\tB-ORG\n)\tO\n,\tO\nwhich\tO\nderives\tO\nits\tO\nname\tO\nfrom\tO\nthe\tO\nfull\tO\nGerman\tO\ntitle\tO\nof\tO\nHitler\tO\n's\tO\nNazi\tT-3\nparty\tT-3\n.\tO\n\nBertram\tT-2\nsaid\tT-5\nLauck\tO\nwas\tO\nobsessed\tO\nby\tO\nNazism\tT-3\nand\tO\ndevoted\tO\nhis\tO\nlife\tO\nto\tO\nleading\tO\nhis\tO\nNational\tT-4\nSocialist\tO\nGerman\tO\nWorkers\tO\n'\tO\nParty\tO\nForeign\tO\nOrganisation\tO\n(\tO\nNSDAP-AO\tO\n)\tO\n,\tO\nwhich\tO\nderives\tT-0\nits\tO\nname\tT-1\nfrom\tO\nthe\tO\nfull\tO\nGerman\tB-MISC\ntitle\tO\nof\tO\nHitler\tO\n's\tO\nNazi\tO\nparty\tO\n.\tT-4\n\nBertram\tT-1\nsaid\tO\nLauck\tO\nwas\tO\nobsessed\tO\nby\tO\nNazism\tO\nand\tO\ndevoted\tO\nhis\tO\nlife\tO\nto\tO\nleading\tO\nhis\tO\nNational\tO\nSocialist\tO\nGerman\tO\nWorkers\tO\n'\tO\nParty\tO\nForeign\tO\nOrganisation\tO\n(\tO\nNSDAP-AO\tO\n)\tO\n,\tO\nwhich\tO\nderives\tO\nits\tO\nname\tO\nfrom\tO\nthe\tO\nfull\tO\nGerman\tO\ntitle\tO\nof\tO\nHitler\tB-PER\n's\tT-0\nNazi\tT-0\nparty\tT-0\n.\tO\n\nBertram\tO\nsaid\tO\nLauck\tO\nwas\tO\nobsessed\tO\nby\tO\nNazism\tO\nand\tO\ndevoted\tO\nhis\tO\nlife\tO\nto\tO\nleading\tO\nhis\tO\nNational\tO\nSocialist\tO\nGerman\tO\nWorkers\tO\n'\tO\nParty\tO\nForeign\tO\nOrganisation\tO\n(\tO\nNSDAP-AO\tT-1\n)\tO\n,\tO\nwhich\tO\nderives\tO\nits\tO\nname\tO\nfrom\tO\nthe\tO\nfull\tO\nGerman\tO\ntitle\tT-0\nof\tT-0\nHitler\tO\n's\tO\nNazi\tB-MISC\nparty\tO\n.\tO\n\nDuring\tO\nthe\tO\nthree-month\tO\ntrial\tO\n,\tO\nthe\tO\ncourt\tO\ndealt\tO\nmainly\tO\nwith\tO\nissues\tO\nof\tO\nthe\tT-3\nNSDAP-AO\tB-ORG\n's\tO\n\"\tO\nNS\tT-0\nKampfruf\tT-0\n\"\tO\n(\tO\n\"\tO\nNational\tO\nSocialist\tO\nBattle\tO\nCry\tO\n\"\tO\n)\tO\nmagazine\tT-4\n,\tO\nfilled\tO\nwith\tO\nreferences\tO\nto\tO\nAryan\tO\nsupremacy\tO\nand\tO\ndefamatory\tT-1\nstatements\tO\nabout\tO\nJews\tT-2\n.\tO\n\nDuring\tO\nthe\tO\nthree-month\tO\ntrial\tO\n,\tO\nthe\tO\ncourt\tO\ndealt\tT-1\nmainly\tO\nwith\tO\nissues\tT-2\nof\tO\nthe\tO\nNSDAP-AO\tO\n's\tO\n\"\tO\nNS\tB-ORG\nKampfruf\tI-ORG\n\"\tO\n(\tO\n\"\tO\nNational\tO\nSocialist\tT-0\nBattle\tO\nCry\tO\n\"\tO\n)\tO\nmagazine\tO\n,\tO\nfilled\tO\nwith\tO\nreferences\tO\nto\tO\nAryan\tO\nsupremacy\tO\nand\tO\ndefamatory\tO\nstatements\tO\nabout\tO\nJews\tT-3\n.\tO\n\nDuring\tO\nthe\tO\nthree-month\tO\ntrial\tO\n,\tO\nthe\tO\ncourt\tT-0\ndealt\tO\nmainly\tO\nwith\tO\nissues\tO\nof\tO\nthe\tO\nNSDAP-AO\tT-1\n's\tO\n\"\tO\nNS\tO\nKampfruf\tT-2\n\"\tO\n(\tO\n\"\tO\nNational\tB-ORG\nSocialist\tI-ORG\nBattle\tI-ORG\nCry\tI-ORG\n\"\tO\n)\tO\nmagazine\tO\n,\tO\nfilled\tO\nwith\tO\nreferences\tO\nto\tO\nAryan\tT-3\nsupremacy\tT-3\nand\tO\ndefamatory\tO\nstatements\tO\nabout\tO\nJews\tO\n.\tO\n\nDuring\tO\nthe\tO\nthree-month\tO\ntrial\tT-0\n,\tO\nthe\tO\ncourt\tO\ndealt\tO\nmainly\tO\nwith\tO\nissues\tO\nof\tO\nthe\tO\nNSDAP-AO\tT-1\n's\tO\n\"\tO\nNS\tO\nKampfruf\tO\n\"\tO\n(\tO\n\"\tO\nNational\tO\nSocialist\tO\nBattle\tO\nCry\tO\n\"\tO\n)\tO\nmagazine\tO\n,\tO\nfilled\tO\nwith\tO\nreferences\tT-2\nto\tT-3\nAryan\tB-MISC\nsupremacy\tT-4\nand\tO\ndefamatory\tO\nstatements\tO\nabout\tO\nJews\tO\n.\tO\n\nDuring\tO\nthe\tO\nthree-month\tO\ntrial\tO\n,\tO\nthe\tO\ncourt\tO\ndealt\tO\nmainly\tO\nwith\tO\nissues\tT-1\nof\tO\nthe\tO\nNSDAP-AO\tT-3\n's\tO\n\"\tO\nNS\tT-4\nKampfruf\tT-4\n\"\tO\n(\tO\n\"\tO\nNational\tT-5\nSocialist\tT-5\nBattle\tT-5\nCry\tT-5\n\"\tO\n)\tO\nmagazine\tO\n,\tO\nfilled\tO\nwith\tO\nreferences\tT-2\nto\tO\nAryan\tO\nsupremacy\tO\nand\tO\ndefamatory\tT-0\nstatements\tT-0\nabout\tO\nJews\tB-MISC\n.\tO\n\nThe\tO\ncourt\tT-1\nrejected\tT-1\nSieg\tB-PER\n's\tO\nargument\tT-0\nthat\tO\nLauck\tO\n's\tO\nextradition\tO\nfrom\tO\nDenmark\tO\n,\tO\nwhere\tO\nhe\tO\nwas\tO\narrested\tT-2\nin\tO\nMarch\tO\nlast\tO\nyear\tO\nat\tO\nthe\tO\nrequest\tO\nof\tO\nGerman\tO\nauthorities\tO\n,\tO\nwas\tO\nillegal\tO\n.\tO\n\nThe\tO\ncourt\tO\nrejected\tO\nSieg\tO\n's\tO\nargument\tO\nthat\tO\nLauck\tB-PER\n's\tT-0\nextradition\tT-0\nfrom\tT-0\nDenmark\tT-0\n,\tO\nwhere\tO\nhe\tT-1\nwas\tO\narrested\tO\nin\tO\nMarch\tO\nlast\tO\nyear\tO\nat\tO\nthe\tO\nrequest\tO\nof\tO\nGerman\tO\nauthorities\tO\n,\tO\nwas\tO\nillegal\tO\n.\tO\n\nThe\tO\ncourt\tO\nrejected\tO\nSieg\tO\n's\tO\nargument\tO\nthat\tO\nLauck\tO\n's\tO\nextradition\tT-2\nfrom\tT-1\nDenmark\tB-LOC\n,\tO\nwhere\tT-0\nhe\tO\nwas\tO\narrested\tT-3\nin\tO\nMarch\tO\nlast\tO\nyear\tO\nat\tO\nthe\tO\nrequest\tO\nof\tO\nGerman\tO\nauthorities\tO\n,\tO\nwas\tO\nillegal\tO\n.\tO\n\nThe\tO\ncourt\tO\nrejected\tO\nSieg\tT-1\n's\tO\nargument\tO\nthat\tO\nLauck\tT-2\n's\tO\nextradition\tO\nfrom\tO\nDenmark\tT-3\n,\tO\nwhere\tO\nhe\tO\nwas\tO\narrested\tO\nin\tO\nMarch\tO\nlast\tO\nyear\tO\nat\tO\nthe\tO\nrequest\tO\nof\tO\nGerman\tB-MISC\nauthorities\tT-0\n,\tO\nwas\tO\nillegal\tO\n.\tO\n\nLauck\tB-PER\nwas\tO\nalso\tO\nconvicted\tT-1\nof\tO\ndisseminating\tO\nthe\tO\nsymbols\tO\nof\tO\nanti-constitutional\tT-0\norganisations\tO\n.\tO\n\nUN\tT-0\nofficial\tT-0\nsays\tO\nIraqi\tB-MISC\ndeal\tT-1\nwill\tO\noccur\tO\n\"\tO\nsoon\tO\n\"\tO\n.\tO\n\nA\tO\nsenior\tO\nU.N.\tB-ORG\nofficial\tT-1\nsaid\tO\non\tO\nThursday\tO\nhe\tO\nexpected\tO\narrangements\tO\nto\tO\nimplement\tO\nthe\tO\nIraqi\tT-2\noil-for-food\tO\ndeal\tT-0\ncould\tO\nbe\tO\ncompleted\tO\n\"\tO\nquite\tO\nsoon\tO\n.\tO\n\"\tO\n\nA\tO\nsenior\tO\nU.N.\tO\nofficial\tO\nsaid\tO\non\tO\nThursday\tO\nhe\tO\nexpected\tO\narrangements\tT-0\nto\tO\nimplement\tT-2\nthe\tO\nIraqi\tB-MISC\noil-for-food\tT-1\ndeal\tO\ncould\tO\nbe\tO\ncompleted\tO\n\"\tO\nquite\tO\nsoon\tO\n.\tO\n\"\tO\n\n\"\tO\nI\tO\nam\tO\nreluctant\tO\nto\tO\nspeculate\tO\nbut\tO\nwe\tO\nare\tO\ndoing\tO\nthe\tO\npreparations\tO\nand\tO\nthe\tO\nsecretary-general\tO\nis\tO\nanxious\tO\nto\tO\nstart\tO\nthe\tO\nprogram\tO\n,\tO\n\"\tO\nsaid\tO\nUndersecretary-General\tT-1\nYasushi\tB-PER\nAkashi\tI-PER\n.\tT-0\n\n\"\tO\nIt\tO\nmight\tO\nbe\tO\nsooner\tO\nthan\tO\nyou\tO\nthink\tO\n,\tO\n\"\tO\nhe\tO\ntold\tT-0\nreporters\tO\nafter\tO\nbriefing\tO\nthe\tO\nSecurity\tB-ORG\nCouncil\tI-ORG\non\tO\narrangements\tO\nfor\tO\nmonitors\tO\nneeded\tO\nto\tO\ncarry\tO\nout\tO\nthe\tO\nagreement\tO\n.\tO\n\nAkashi\tB-PER\nis\tT-0\nhead\tT-0\nof\tT-0\nthe\tO\nDepartment\tT-1\nof\tT-1\nHumanitarian\tT-1\naffairs\tT-1\n.\tO\n\nAkashi\tT-0\nis\tO\nhead\tT-1\nof\tO\nthe\tO\nDepartment\tB-ORG\nof\tI-ORG\nHumanitarian\tI-ORG\naffairs\tI-ORG\n.\tO\n\nSuspected\tO\nkillers\tT-0\nof\tT-0\nbishop\tO\ndead\tO\n--\tO\nAlgeria\tB-ORG\nTV\tI-ORG\n.\tO\n\nAlgerian\tB-MISC\nsecurity\tO\nforces\tO\nhave\tT-2\nshot\tT-3\ndead\tO\nthree\tO\nMoslem\tT-0\nguerrillas\tT-0\nsuspected\tO\nof\tO\nkilling\tO\na\tO\nleading\tO\nFrench\tT-1\nbishop\tT-1\nin\tO\nwestern\tO\nAlgeria\tO\n,\tO\nthe\tO\nAlgerian\tO\nstate-run\tO\ntelevision\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nAlgerian\tO\nsecurity\tO\nforces\tO\nhave\tO\nshot\tT-0\ndead\tT-0\nthree\tT-0\nMoslem\tB-MISC\nguerrillas\tT-2\nsuspected\tT-1\nof\tO\nkilling\tO\na\tO\nleading\tO\nFrench\tO\nbishop\tO\nin\tO\nwestern\tT-3\nAlgeria\tT-3\n,\tO\nthe\tO\nAlgerian\tO\nstate-run\tO\ntelevision\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nAlgerian\tO\nsecurity\tO\nforces\tO\nhave\tO\nshot\tO\ndead\tO\nthree\tO\nMoslem\tO\nguerrillas\tO\nsuspected\tO\nof\tO\nkilling\tO\na\tT-0\nleading\tT-0\nFrench\tB-MISC\nbishop\tO\nin\tO\nwestern\tO\nAlgeria\tO\n,\tO\nthe\tO\nAlgerian\tO\nstate-run\tO\ntelevision\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nAlgerian\tO\nsecurity\tO\nforces\tO\nhave\tO\nshot\tO\ndead\tO\nthree\tO\nMoslem\tT-0\nguerrillas\tT-0\nsuspected\tO\nof\tO\nkilling\tT-1\na\tO\nleading\tO\nFrench\tT-2\nbishop\tT-2\nin\tO\nwestern\tO\nAlgeria\tB-LOC\n,\tO\nthe\tO\nAlgerian\tT-3\nstate-run\tO\ntelevision\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nAlgerian\tT-1\nsecurity\tT-1\nforces\tT-1\nhave\tO\nshot\tO\ndead\tO\nthree\tO\nMoslem\tT-2\nguerrillas\tT-2\nsuspected\tO\nof\tO\nkilling\tO\na\tO\nleading\tO\nFrench\tO\nbishop\tO\nin\tO\nwestern\tO\nAlgeria\tO\n,\tO\nthe\tO\nAlgerian\tB-MISC\nstate-run\tT-0\ntelevision\tT-0\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nSecurity\tT-0\nforces\tO\nalso\tO\narrested\tT-2\nfour\tO\nother\tO\nmen\tO\nsought\tO\nfor\tO\ngiving\tO\nsupport\tT-3\nto\tO\nthe\tO\nslain\tT-4\nMoslem\tB-MISC\nrebels\tT-1\n,\tO\nthe\tO\ntelevision\tO\nsaid\tO\n.\tO\n\nThe\tO\ntelevision\tT-3\n,\tO\nwhich\tO\ndid\tO\nnot\tO\nsay\tO\nwhen\tO\nthe\tO\nsecurity\tO\nforces\tO\nkilled\tO\nthe\tO\nrebels\tO\n,\tO\nsaid\tT-0\nthe\tO\nfour\tO\narrested\tO\nmen\tO\nconfessed\tO\ndetails\tO\nof\tO\nthe\tO\nassassination\tT-1\nof\tO\nthe\tO\nFrench\tB-MISC\nRoman\tO\nCatholic\tO\nBishop\tO\nPierre\tT-2\nClaverie\tT-2\n.\tO\n\nThe\tO\ntelevision\tO\n,\tO\nwhich\tO\ndid\tO\nnot\tO\nsay\tO\nwhen\tO\nthe\tO\nsecurity\tO\nforces\tO\nkilled\tT-0\nthe\tO\nrebels\tO\n,\tO\nsaid\tT-1\nthe\tO\nfour\tO\narrested\tO\nmen\tT-2\nconfessed\tT-5\ndetails\tO\nof\tO\nthe\tO\nassassination\tT-3\nof\tO\nthe\tO\nFrench\tT-4\nRoman\tB-MISC\nCatholic\tI-MISC\nBishop\tO\nPierre\tO\nClaverie\tO\n.\tO\n\nThe\tO\n58-year-old\tO\nClaverie\tB-PER\nwas\tO\nkilled\tO\nin\tO\nAugust\tO\n1\tO\nin\tO\na\tO\nbomb\tT-1\nblast\tT-1\nat\tO\nhis\tO\nresidence\tO\nin\tO\nthe\tO\nwestern\tO\nAlgerian\tO\ncity\tO\nof\tO\nOran\tO\n,\tO\nhours\tO\nafter\tO\nhe\tO\nmet\tO\nvisiting\tO\nFrench\tO\nForeign\tO\nMinister\tT-0\nHerve\tO\nde\tO\nCharette\tT-2\nin\tO\nAlgiers\tO\n.\tO\n\nThe\tO\n58-year-old\tO\nClaverie\tO\nwas\tO\nkilled\tO\nin\tO\nAugust\tO\n1\tO\nin\tO\na\tO\nbomb\tO\nblast\tO\nat\tO\nhis\tO\nresidence\tO\nin\tT-2\nthe\tT-2\nwestern\tT-2\nAlgerian\tB-MISC\ncity\tO\nof\tO\nOran\tO\n,\tO\nhours\tO\nafter\tO\nhe\tO\nmet\tO\nvisiting\tO\nFrench\tO\nForeign\tO\nMinister\tO\nHerve\tT-0\nde\tT-0\nCharette\tT-0\nin\tO\nAlgiers\tT-1\n.\tO\n\nThe\tO\n58-year-old\tO\nClaverie\tT-1\nwas\tO\nkilled\tO\nin\tO\nAugust\tO\n1\tO\nin\tO\na\tO\nbomb\tT-2\nblast\tT-2\nat\tO\nhis\tO\nresidence\tO\nin\tO\nthe\tO\nwestern\tO\nAlgerian\tO\ncity\tT-0\nof\tO\nOran\tB-LOC\n,\tO\nhours\tO\nafter\tO\nhe\tO\nmet\tO\nvisiting\tO\nFrench\tO\nForeign\tO\nMinister\tO\nHerve\tO\nde\tO\nCharette\tO\nin\tO\nAlgiers\tO\n.\tO\n\nThe\tO\n58-year-old\tO\nClaverie\tO\nwas\tO\nkilled\tO\nin\tO\nAugust\tO\n1\tO\nin\tO\na\tO\nbomb\tT-0\nblast\tT-0\nat\tO\nhis\tO\nresidence\tO\nin\tO\nthe\tO\nwestern\tO\nAlgerian\tO\ncity\tO\nof\tO\nOran\tO\n,\tO\nhours\tO\nafter\tO\nhe\tO\nmet\tO\nvisiting\tT-2\nFrench\tB-MISC\nForeign\tO\nMinister\tO\nHerve\tO\nde\tO\nCharette\tO\nin\tO\nAlgiers\tT-1\n.\tO\n\nThe\tO\n58-year-old\tO\nClaverie\tT-0\nwas\tO\nkilled\tO\nin\tO\nAugust\tO\n1\tO\nin\tO\na\tO\nbomb\tO\nblast\tO\nat\tO\nhis\tO\nresidence\tO\nin\tO\nthe\tO\nwestern\tO\nAlgerian\tO\ncity\tO\nof\tO\nOran\tO\n,\tO\nhours\tO\nafter\tO\nhe\tO\nmet\tO\nvisiting\tT-1\nFrench\tO\nForeign\tO\nMinister\tO\nHerve\tB-PER\nde\tI-PER\nCharette\tI-PER\nin\tO\nAlgiers\tO\n.\tO\n\nThe\tO\n58-year-old\tO\nClaverie\tO\nwas\tO\nkilled\tO\nin\tO\nAugust\tO\n1\tO\nin\tO\na\tO\nbomb\tO\nblast\tO\nat\tO\nhis\tO\nresidence\tT-1\nin\tO\nthe\tO\nwestern\tO\nAlgerian\tO\ncity\tT-2\nof\tT-2\nOran\tO\n,\tO\nhours\tO\nafter\tO\nhe\tO\nmet\tO\nvisiting\tO\nFrench\tO\nForeign\tO\nMinister\tO\nHerve\tO\nde\tO\nCharette\tT-0\nin\tO\nAlgiers\tB-LOC\n.\tO\n\nAn\tO\nestimated\tO\n50,000\tO\nAlgerians\tB-MISC\nand\tT-4\nmore\tO\nthan\tO\n110\tO\nforeigners\tO\nhave\tO\nbeen\tO\nkilled\tT-3\nin\tO\nAlgeria\tO\n's\tO\nviolence\tT-0\npitting\tT-0\nMoslem\tO\nrebels\tT-1\nagainst\tO\nthe\tO\nAlgerian\tO\ngovernment\tO\nforces\tO\nsince\tO\nearly\tO\n1992\tO\n,\tO\nwhen\tO\nthe\tO\nauthorities\tO\ncancelled\tT-2\na\tT-2\ngeneral\tT-2\nelection\tT-2\nin\tO\nwhich\tO\nradical\tO\nIslamists\tO\ntook\tO\na\tO\ncommanding\tO\nlead\tO\n.\tO\n\nAn\tO\nestimated\tO\n50,000\tO\nAlgerians\tO\nand\tO\nmore\tO\nthan\tO\n110\tT-2\nforeigners\tT-2\nhave\tO\nbeen\tO\nkilled\tT-0\nin\tO\nAlgeria\tB-LOC\n's\tO\nviolence\tO\npitting\tO\nMoslem\tT-6\nrebels\tT-1\nagainst\tO\nthe\tO\nAlgerian\tT-3\ngovernment\tT-3\nforces\tO\nsince\tO\nearly\tO\n1992\tO\n,\tO\nwhen\tO\nthe\tO\nauthorities\tO\ncancelled\tO\na\tO\ngeneral\tT-4\nelection\tT-4\nin\tO\nwhich\tO\nradical\tO\nIslamists\tT-5\ntook\tO\na\tO\ncommanding\tO\nlead\tO\n.\tO\n\nAn\tO\nestimated\tO\n50,000\tO\nAlgerians\tO\nand\tO\nmore\tO\nthan\tO\n110\tO\nforeigners\tO\nhave\tO\nbeen\tO\nkilled\tO\nin\tO\nAlgeria\tO\n's\tO\nviolence\tO\npitting\tO\nMoslem\tB-MISC\nrebels\tT-5\nagainst\tO\nthe\tO\nAlgerian\tT-2\ngovernment\tT-2\nforces\tT-0\nsince\tO\nearly\tO\n1992\tO\n,\tO\nwhen\tO\nthe\tO\nauthorities\tO\ncancelled\tT-3\na\tO\ngeneral\tT-4\nelection\tT-4\nin\tO\nwhich\tO\nradical\tO\nIslamists\tO\ntook\tO\na\tO\ncommanding\tO\nlead\tT-1\n.\tO\n\nAn\tO\nestimated\tO\n50,000\tO\nAlgerians\tO\nand\tO\nmore\tO\nthan\tO\n110\tO\nforeigners\tO\nhave\tO\nbeen\tO\nkilled\tO\nin\tO\nAlgeria\tT-2\n's\tO\nviolence\tO\npitting\tO\nMoslem\tT-3\nrebels\tO\nagainst\tO\nthe\tT-0\nAlgerian\tB-MISC\ngovernment\tT-1\nforces\tT-1\nsince\tO\nearly\tO\n1992\tO\n,\tO\nwhen\tO\nthe\tO\nauthorities\tO\ncancelled\tO\na\tO\ngeneral\tO\nelection\tO\nin\tO\nwhich\tO\nradical\tO\nIslamists\tO\ntook\tO\na\tO\ncommanding\tO\nlead\tO\n.\tO\n\nAn\tO\nestimated\tO\n50,000\tO\nAlgerians\tT-0\nand\tO\nmore\tO\nthan\tO\n110\tO\nforeigners\tO\nhave\tO\nbeen\tO\nkilled\tT-2\nin\tO\nAlgeria\tO\n's\tO\nviolence\tO\npitting\tO\nMoslem\tT-1\nrebels\tT-1\nagainst\tO\nthe\tO\nAlgerian\tO\ngovernment\tO\nforces\tO\nsince\tO\nearly\tO\n1992\tO\n,\tO\nwhen\tO\nthe\tO\nauthorities\tO\ncancelled\tO\na\tO\ngeneral\tO\nelection\tO\nin\tO\nwhich\tT-3\nradical\tT-3\nIslamists\tB-MISC\ntook\tO\na\tO\ncommanding\tO\nlead\tO\n.\tO\n\nGerman\tB-MISC\nflown\tT-0\ncargo\tO\nJanuary-July\tO\nrise\tO\n3.8\tO\npercent\tO\n.\tO\n\nThe\tO\nfollowing\tO\ntable\tO\nshows\tO\ntotal\tO\nflown\tO\nair\tT-1\ncargo\tT-1\nvolumes\tO\nin\tO\ntonnes\tT-2\nhandled\tT-3\nat\tO\ninternational\tO\nGerman\tB-MISC\nairports\tT-0\nJanuary-July\tO\n1996\tO\n.\tO\n\nThe\tO\nfigures\tO\nexclude\tO\ntrucked\tO\nairfreight\tT-0\naccording\tO\nto\tO\nthe\tO\nGerman\tB-MISC\nairports\tT-1\nassociation\tO\nADV\tO\n.\tO\n\n-\tO\nTegel\tB-LOC\n10,896\tT-0\nup\tO\n3.1\tO\n\n-\tO\nTempelhof\tB-LOC\n202\tO\ndown\tT-0\n60.0\tO\n\nBremen\tB-LOC\n1,453\tT-0\nup\tT-0\n13.1\tT-0\n\nDresden\tB-LOC\n792\tT-0\nup\tT-0\n11.4\tT-0\n\nDuessseldorf\tB-LOC\n31,347\tO\ndown\tT-0\n4.4\tO\n\nHamburg\tB-LOC\n21,240\tT-0\ndown\tT-0\n3.5\tT-0\n\nKoeln\tB-LOC\n(\tO\nCologne\tT-0\n)\tO\n182,887\tO\nup\tO\n11.8\tO\n\nKoeln\tT-0\n(\tO\nCologne\tB-LOC\n)\tO\n182,887\tO\nup\tO\n11.8\tO\n\nLeipzig\tB-LOC\n/\tO\nHalle\tT-0\n1,806\tO\nup\tO\n45.6\tO\n\nLeipzig\tT-0\n/\tT-0\nHalle\tB-LOC\n1,806\tO\nup\tO\n45.6\tO\n\nMunich\tB-LOC\n44,525\tT-0\nup\tO\n11.8\tO\n\nMuenster\tB-LOC\n/\tO\nOsnabrueck\tT-0\n382\tO\nup\tO\n28.2\tO\n\nMuenster\tT-0\n/\tO\nOsnabrueck\tB-LOC\n382\tO\nup\tO\n28.2\tO\n\nSaarbruecken\tB-LOC\n626\tT-0\nup\tT-0\n28.3\tT-0\n\nStuttgart\tB-LOC\n10,655\tT-0\nup\tO\n11.7\tT-1\n\n-\tO\nAir\tB-ORG\nCargo\tI-ORG\nNewsroom\tI-ORG\nTel+44\tT-1\n161\tT-1\n542\tT-1\n7706\tT-1\nFax+44\tT-0\n171\tO\n542\tO\n5017\tT-0\n\nParibas\tB-ORG\nrepeats\tO\nbuy\tT-0\non\tO\nAegon\tT-1\nafter\tO\nresults\tO\n.\tO\n\nParibas\tT-0\nrepeats\tO\nbuy\tO\non\tO\nAegon\tB-ORG\nafter\tO\nresults\tT-1\n.\tO\n\nAegon\tT-0\n83.40\tO\nParibas\tB-ORG\n\nCOMMENT\tO\n:\tO\n\"\tO\nNot\tO\nonly\tO\ndid\tO\nAegon\tB-ORG\nsurprise\tO\nwith\tO\nearnings\tT-0\nof\tO\n711\tO\nmillion\tO\nguilders\tO\n,\tO\nwhich\tT-1\nwere\tT-1\nabove\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nexpected\tO\nrange\tO\n,\tO\nit\tO\nalso\tO\nforecast\tO\na\tO\nsimilar\tO\nperformance\tO\nin\tO\nthe\tO\nsecond\tO\nhalf\tO\n.\tO\n\"\tO\n\nEstimates\tO\n(\tO\nDfl\tB-MISC\n)\tO\n:\tO\nEPS\tT-0\nP\tT-0\n/\tT-0\nE\tT-0\nDividend\tO\n\nClinton\tB-PER\n's\tO\nBallybunion\tO\nfans\tT-1\ninvited\tT-0\nto\tO\nChicago\tO\n.\tO\n\nClinton\tT-0\n's\tT-0\nBallybunion\tB-ORG\nfans\tO\ninvited\tO\nto\tO\nChicago\tO\n.\tO\n\nClinton\tO\n's\tO\nBallybunion\tT-1\nfans\tT-1\ninvited\tT-0\nto\tO\nChicago\tB-LOC\n.\tO\n\nU.S.\tB-LOC\nPresident\tT-0\nBill\tO\nClinton\tO\nhad\tO\nto\tO\ndrop\tO\nthe\tO\nresort\tT-1\nof\tO\nBallybunion\tO\nfrom\tO\na\tO\nwhirlwind\tO\nIrish\tO\ntour\tO\nlast\tO\nyear\tO\n.\tO\n\nU.S.\tO\nPresident\tT-1\nBill\tB-PER\nClinton\tI-PER\nhad\tT-0\nto\tT-0\ndrop\tT-0\nthe\tO\nresort\tO\nof\tO\nBallybunion\tT-2\nfrom\tO\na\tO\nwhirlwind\tO\nIrish\tT-3\ntour\tO\nlast\tO\nyear\tO\n.\tO\n\nU.S.\tO\nPresident\tO\nBill\tO\nClinton\tO\nhad\tO\nto\tO\ndrop\tT-0\nthe\tO\nresort\tO\nof\tO\nBallybunion\tB-ORG\nfrom\tO\na\tO\nwhirlwind\tT-2\nIrish\tT-1\ntour\tT-1\nlast\tO\nyear\tO\n.\tO\n\nU.S.\tO\nPresident\tO\nBill\tO\nClinton\tO\nhad\tO\nto\tO\ndrop\tT-0\nthe\tO\nresort\tO\nof\tO\nBallybunion\tO\nfrom\tO\na\tO\nwhirlwind\tO\nIrish\tB-MISC\ntour\tO\nlast\tO\nyear\tO\n.\tO\n\nSo\tO\nBallybunion\tB-ORG\nis\tO\ngoing\tO\nto\tO\nAmerica\tT-0\ninstead\tO\n.\tO\n\nTwo\tO\nresidents\tT-1\nof\tO\nthe\tO\nAtlantic\tB-LOC\nresort\tT-0\n,\tO\nwhere\tO\nClinton\tO\nwas\tO\nto\tO\nhave\tO\nplayed\tT-2\ngolf\tO\nwith\tO\nthe\tO\nIrish\tO\nForeign\tO\nMinister\tO\nDick\tO\nSpring\tO\n,\tO\nhave\tO\nbeen\tO\ninvited\tO\nto\tO\nthe\tO\nDemocratic\tO\nparty\tO\nconvention\tO\nin\tO\nChicago\tO\non\tO\nAugust\tO\n26-29\tO\n.\tO\n\nTwo\tO\nresidents\tT-0\nof\tO\nthe\tO\nAtlantic\tO\nresort\tO\n,\tO\nwhere\tO\nClinton\tB-PER\nwas\tO\nto\tO\nhave\tO\nplayed\tO\ngolf\tO\nwith\tO\nthe\tO\nIrish\tO\nForeign\tO\nMinister\tO\nDick\tO\nSpring\tO\n,\tO\nhave\tO\nbeen\tO\ninvited\tT-1\nto\tO\nthe\tO\nDemocratic\tO\nparty\tO\nconvention\tO\nin\tO\nChicago\tO\non\tO\nAugust\tO\n26-29\tO\n.\tO\n\nTwo\tO\nresidents\tO\nof\tO\nthe\tO\nAtlantic\tT-1\nresort\tT-1\n,\tO\nwhere\tO\nClinton\tO\nwas\tO\nto\tO\nhave\tO\nplayed\tO\ngolf\tT-0\nwith\tO\nthe\tO\nIrish\tB-MISC\nForeign\tT-2\nMinister\tT-2\nDick\tO\nSpring\tO\n,\tO\nhave\tO\nbeen\tO\ninvited\tO\nto\tO\nthe\tO\nDemocratic\tO\nparty\tO\nconvention\tO\nin\tO\nChicago\tO\non\tO\nAugust\tO\n26-29\tO\n.\tO\n\nTwo\tO\nresidents\tO\nof\tO\nthe\tO\nAtlantic\tT-0\nresort\tO\n,\tO\nwhere\tO\nClinton\tO\nwas\tO\nto\tO\nhave\tO\nplayed\tO\ngolf\tO\nwith\tO\nthe\tO\nIrish\tT-1\nForeign\tT-1\nMinister\tT-1\nDick\tB-PER\nSpring\tI-PER\n,\tO\nhave\tO\nbeen\tO\ninvited\tO\nto\tO\nthe\tO\nDemocratic\tT-2\nparty\tT-2\nconvention\tT-2\nin\tO\nChicago\tT-3\non\tO\nAugust\tO\n26-29\tO\n.\tO\n\nTwo\tO\nresidents\tO\nof\tO\nthe\tO\nAtlantic\tT-0\nresort\tO\n,\tO\nwhere\tO\nClinton\tO\nwas\tO\nto\tO\nhave\tO\nplayed\tO\ngolf\tO\nwith\tO\nthe\tO\nIrish\tO\nForeign\tO\nMinister\tO\nDick\tO\nSpring\tO\n,\tO\nhave\tO\nbeen\tO\ninvited\tO\nto\tO\nthe\tO\nDemocratic\tB-MISC\nparty\tO\nconvention\tT-1\nin\tO\nChicago\tO\non\tO\nAugust\tO\n26-29\tO\n.\tO\n\nTwo\tO\nresidents\tO\nof\tO\nthe\tO\nAtlantic\tT-3\nresort\tT-3\n,\tO\nwhere\tO\nClinton\tT-1\nwas\tO\nto\tO\nhave\tO\nplayed\tO\ngolf\tO\nwith\tO\nthe\tO\nIrish\tO\nForeign\tO\nMinister\tO\nDick\tO\nSpring\tO\n,\tO\nhave\tO\nbeen\tO\ninvited\tO\nto\tO\nthe\tO\nDemocratic\tO\nparty\tT-2\nconvention\tT-0\nin\tO\nChicago\tB-LOC\non\tO\nAugust\tO\n26-29\tO\n.\tO\n\nThey\tO\nhave\tO\nbeen\tO\nasked\tO\nto\tO\nbring\tO\nwith\tO\nthem\tO\nthe\tO\nplacards\tO\nthey\tO\nwaved\tO\nwhen\tO\nClinton\tB-PER\naddressed\tT-0\nIreland\tO\nat\tO\na\tO\npacked\tO\nceremony\tO\nin\tO\nDublin\tO\ncity\tO\ncentre\tO\non\tO\nDecember\tO\n1\tO\n,\tO\nlast\tO\nyear\tO\n.\tO\n\nThey\tO\nhave\tO\nbeen\tO\nasked\tO\nto\tO\nbring\tO\nwith\tO\nthem\tO\nthe\tO\nplacards\tT-2\nthey\tO\nwaved\tO\nwhen\tO\nClinton\tO\naddressed\tO\nIreland\tB-LOC\nat\tT-0\na\tO\npacked\tO\nceremony\tO\nin\tO\nDublin\tT-1\ncity\tT-1\ncentre\tO\non\tO\nDecember\tO\n1\tO\n,\tO\nlast\tO\nyear\tO\n.\tO\n\nThey\tO\nhave\tO\nbeen\tO\nasked\tT-1\nto\tO\nbring\tO\nwith\tO\nthem\tO\nthe\tO\nplacards\tO\nthey\tO\nwaved\tT-2\nwhen\tO\nClinton\tO\naddressed\tT-3\nIreland\tO\nat\tO\na\tO\npacked\tO\nceremony\tO\nin\tT-4\nDublin\tB-LOC\ncity\tT-0\ncentre\tO\non\tO\nDecember\tO\n1\tO\n,\tO\nlast\tO\nyear\tO\n.\tO\n\nThey\tO\nread\tO\n:\tO\n\"\tO\nBallybunion\tB-ORG\nbacks\tT-0\nClinton\tT-0\n.\tO\n\"\tO\n\nThey\tO\nread\tO\n:\tO\n\"\tO\nBallybunion\tT-1\nbacks\tT-0\nClinton\tB-PER\n.\tO\n\"\tO\n\n\"\tO\nThe\tO\nDemocratic\tB-MISC\nparty\tT-0\nhave\tO\nrequested\tO\nwe\tO\nbring\tO\nour\tO\nplacards\tO\nwith\tO\nus\tO\n.\tO\n\nWe\tO\nwill\tO\nbe\tO\nguests\tT-0\nof\tO\nthe\tO\nKennedys\tB-PER\n,\tO\n\"\tO\nsaid\tO\nFrank\tT-2\nQuilter\tT-2\n,\tO\none\tO\nof\tO\nthe\tO\ntwo\tO\nwho\tO\nhave\tO\nbeen\tO\ninvited\tT-1\nto\tO\nChicago\tT-3\n.\tO\n\nWe\tO\nwill\tO\nbe\tO\nguests\tO\nof\tO\nthe\tO\nKennedys\tT-0\n,\tO\n\"\tO\nsaid\tO\nFrank\tT-1\nQuilter\tT-1\n,\tO\none\tO\nof\tO\nthe\tO\ntwo\tO\nwho\tO\nhave\tO\nbeen\tO\ninvited\tO\nto\tO\nChicago\tB-LOC\n.\tO\n\nClinton\tB-PER\nmade\tO\na\tO\ntriumphant\tT-0\nIrish\tT-1\ntour\tT-1\nto\tO\nback\tO\na\tO\nNorthern\tT-3\nIreland\tT-3\npeace\tT-2\nprocess\tT-2\nbut\tO\nwas\tO\nforced\tO\nto\tO\ndrop\tO\nBallybunion\tT-4\nfrom\tO\na\tO\npacked\tO\nschedule\tO\nat\tO\nthe\tO\nlast\tO\nminute\tO\n.\tO\n\nClinton\tO\nmade\tO\na\tO\ntriumphant\tT-0\nIrish\tB-MISC\ntour\tO\nto\tO\nback\tO\na\tO\nNorthern\tO\nIreland\tO\npeace\tO\nprocess\tO\nbut\tO\nwas\tO\nforced\tO\nto\tO\ndrop\tO\nBallybunion\tO\nfrom\tO\na\tO\npacked\tO\nschedule\tO\nat\tO\nthe\tO\nlast\tO\nminute\tO\n.\tO\n\nClinton\tO\nmade\tO\na\tO\ntriumphant\tO\nIrish\tO\ntour\tT-1\nto\tO\nback\tT-2\na\tO\nNorthern\tB-LOC\nIreland\tI-LOC\npeace\tO\nprocess\tO\nbut\tO\nwas\tO\nforced\tO\nto\tO\ndrop\tO\nBallybunion\tT-0\nfrom\tO\na\tO\npacked\tO\nschedule\tO\nat\tO\nthe\tO\nlast\tO\nminute\tO\n.\tO\n\nClinton\tT-2\nmade\tO\na\tO\ntriumphant\tO\nIrish\tT-4\ntour\tO\nto\tO\nback\tO\na\tO\nNorthern\tO\nIreland\tT-3\npeace\tO\nprocess\tO\nbut\tO\nwas\tO\nforced\tO\nto\tO\ndrop\tT-1\nBallybunion\tB-ORG\nfrom\tO\na\tO\npacked\tO\nschedule\tT-0\nat\tO\nthe\tO\nlast\tO\nminute\tO\n.\tT-0\n\nBonn\tB-LOC\nsays\tO\nMoscow\tT-0\nhas\tO\npromised\tT-2\nto\tT-2\nobserve\tO\nceasefire\tT-1\n.\tO\n\nBonn\tO\nsays\tO\nMoscow\tB-LOC\nhas\tT-2\npromised\tT-2\nto\tO\nobserve\tT-1\nceasefire\tO\n.\tO\n\nGermany\tB-LOC\nsaid\tO\non\tO\nThursday\tO\nit\tT-3\nhad\tT-3\nreceived\tO\nassurances\tO\nfrom\tT-0\nthe\tT-0\nRussian\tT-0\ngovernment\tT-0\nthat\tO\nits\tO\nforces\tO\nwould\tO\nobserve\tT-1\nthe\tO\nlatest\tO\nceasefire\tT-2\nin\tO\nChechnya\tO\n.\tO\n\nGermany\tO\nsaid\tO\non\tO\nThursday\tO\nit\tO\nhad\tO\nreceived\tT-0\nassurances\tT-0\nfrom\tO\nthe\tO\nRussian\tB-MISC\ngovernment\tT-2\nthat\tT-1\nits\tO\nforces\tO\nwould\tO\nobserve\tO\nthe\tO\nlatest\tO\nceasefire\tO\nin\tO\nChechnya\tO\n.\tO\n\nGermany\tO\nsaid\tT-3\non\tO\nThursday\tO\nit\tO\nhad\tO\nreceived\tO\nassurances\tT-0\nfrom\tO\nthe\tO\nRussian\tO\ngovernment\tO\nthat\tO\nits\tO\nforces\tT-1\nwould\tO\nobserve\tT-2\nthe\tO\nlatest\tO\nceasefire\tO\nin\tO\nChechnya\tB-LOC\n.\tO\n\nForeign\tB-ORG\nMinistry\tI-ORG\nspokesman\tO\nMartin\tO\nErdmann\tO\nsaid\tT-0\ntop\tO\nBonn\tO\ndiplomat\tO\nWolfgang\tT-1\nIschinger\tO\nhad\tO\nbeen\tO\nassured\tO\nby\tO\nsenior\tO\nRussian\tO\nofficials\tO\nthat\tO\nthe\tO\nultimatum\tO\nto\tO\nstorm\tO\nand\tO\ntake\tO\nthe\tO\nChechen\tO\ncapital\tO\nof\tO\nGrozny\tO\nwas\tO\nnot\tO\nvalid\tO\n.\tO\n\nForeign\tO\nMinistry\tO\nspokesman\tT-0\nMartin\tB-PER\nErdmann\tI-PER\nsaid\tT-1\ntop\tO\nBonn\tO\ndiplomat\tO\nWolfgang\tT-2\nIschinger\tT-3\nhad\tO\nbeen\tO\nassured\tO\nby\tO\nsenior\tO\nRussian\tO\nofficials\tO\nthat\tO\nthe\tO\nultimatum\tO\nto\tO\nstorm\tO\nand\tO\ntake\tO\nthe\tO\nChechen\tO\ncapital\tO\nof\tO\nGrozny\tO\nwas\tO\nnot\tO\nvalid\tO\n.\tO\n\nForeign\tO\nMinistry\tO\nspokesman\tO\nMartin\tO\nErdmann\tO\nsaid\tO\ntop\tO\nBonn\tB-LOC\ndiplomat\tO\nWolfgang\tT-0\nIschinger\tT-0\nhad\tO\nbeen\tO\nassured\tO\nby\tO\nsenior\tO\nRussian\tO\nofficials\tO\nthat\tO\nthe\tO\nultimatum\tO\nto\tO\nstorm\tO\nand\tO\ntake\tO\nthe\tO\nChechen\tO\ncapital\tO\nof\tO\nGrozny\tO\nwas\tO\nnot\tO\nvalid\tO\n.\tO\n\nForeign\tO\nMinistry\tO\nspokesman\tO\nMartin\tO\nErdmann\tO\nsaid\tO\ntop\tO\nBonn\tO\ndiplomat\tT-1\nWolfgang\tB-PER\nIschinger\tI-PER\nhad\tO\nbeen\tO\nassured\tT-2\nby\tO\nsenior\tO\nRussian\tT-0\nofficials\tO\nthat\tO\nthe\tO\nultimatum\tO\nto\tO\nstorm\tO\nand\tO\ntake\tO\nthe\tO\nChechen\tO\ncapital\tO\nof\tO\nGrozny\tO\nwas\tO\nnot\tO\nvalid\tO\n.\tO\n\nForeign\tO\nMinistry\tO\nspokesman\tT-0\nMartin\tO\nErdmann\tO\nsaid\tO\ntop\tO\nBonn\tO\ndiplomat\tO\nWolfgang\tO\nIschinger\tO\nhad\tO\nbeen\tO\nassured\tO\nby\tO\nsenior\tT-1\nRussian\tB-MISC\nofficials\tO\nthat\tO\nthe\tO\nultimatum\tO\nto\tO\nstorm\tO\nand\tO\ntake\tO\nthe\tO\nChechen\tO\ncapital\tO\nof\tO\nGrozny\tO\nwas\tO\nnot\tO\nvalid\tO\n.\tO\n\nForeign\tO\nMinistry\tO\nspokesman\tO\nMartin\tO\nErdmann\tO\nsaid\tO\ntop\tO\nBonn\tO\ndiplomat\tO\nWolfgang\tO\nIschinger\tO\nhad\tO\nbeen\tO\nassured\tT-2\nby\tO\nsenior\tO\nRussian\tO\nofficials\tO\nthat\tO\nthe\tO\nultimatum\tO\nto\tO\nstorm\tO\nand\tO\ntake\tO\nthe\tT-0\nChechen\tB-MISC\ncapital\tT-1\nof\tO\nGrozny\tO\nwas\tO\nnot\tO\nvalid\tO\n.\tO\n\nForeign\tO\nMinistry\tO\nspokesman\tO\nMartin\tO\nErdmann\tO\nsaid\tO\ntop\tO\nBonn\tO\ndiplomat\tO\nWolfgang\tO\nIschinger\tO\nhad\tO\nbeen\tO\nassured\tO\nby\tO\nsenior\tO\nRussian\tO\nofficials\tO\nthat\tO\nthe\tO\nultimatum\tO\nto\tO\nstorm\tO\nand\tO\ntake\tO\nthe\tO\nChechen\tO\ncapital\tT-0\nof\tO\nGrozny\tB-LOC\nwas\tO\nnot\tO\nvalid\tO\n.\tO\n\n\"\tO\nThe\tO\nRussian\tB-MISC\nside\tT-2\nconfirmed\tT-0\nthat\tO\nthe\tO\nceasefire\tO\nis\tO\nin\tO\nplace\tO\nand\tO\nthey\tO\nwill\tO\nkeep\tO\nto\tO\nit\tO\n,\tO\n\"\tO\nErdmann\tO\ntold\tO\nReuters\tO\nafter\tO\nspeaking\tO\nby\tO\ntelephone\tO\nto\tO\nIschinger\tT-1\n,\tO\nwho\tO\nhad\tO\nmet\tO\nthe\tO\nofficials\tO\non\tO\na\tO\ntwo-day\tO\nvisit\tO\nto\tO\nMoscow\tO\n.\tO\n\n\"\tO\nThe\tO\nRussian\tO\nside\tO\nconfirmed\tO\nthat\tO\nthe\tO\nceasefire\tO\nis\tO\nin\tO\nplace\tO\nand\tO\nthey\tO\nwill\tO\nkeep\tO\nto\tO\nit\tO\n,\tO\n\"\tO\nErdmann\tB-PER\ntold\tT-1\nReuters\tT-1\nafter\tO\nspeaking\tO\nby\tO\ntelephone\tO\nto\tO\nIschinger\tO\n,\tO\nwho\tO\nhad\tO\nmet\tO\nthe\tO\nofficials\tO\non\tO\na\tO\ntwo-day\tO\nvisit\tO\nto\tO\nMoscow\tO\n.\tO\n\n\"\tO\nThe\tO\nRussian\tO\nside\tO\nconfirmed\tO\nthat\tO\nthe\tO\nceasefire\tO\nis\tO\nin\tO\nplace\tO\nand\tO\nthey\tO\nwill\tO\nkeep\tO\nto\tO\nit\tO\n,\tO\n\"\tO\nErdmann\tO\ntold\tO\nReuters\tB-ORG\nafter\tO\nspeaking\tO\nby\tO\ntelephone\tO\nto\tO\nIschinger\tO\n,\tO\nwho\tO\nhad\tO\nmet\tT-0\nthe\tO\nofficials\tO\non\tO\na\tO\ntwo-day\tO\nvisit\tO\nto\tO\nMoscow\tO\n.\tO\n\n\"\tO\nThe\tO\nRussian\tO\nside\tO\nconfirmed\tT-0\nthat\tO\nthe\tO\nceasefire\tO\nis\tO\nin\tO\nplace\tO\nand\tO\nthey\tO\nwill\tO\nkeep\tO\nto\tO\nit\tO\n,\tO\n\"\tO\nErdmann\tO\ntold\tO\nReuters\tO\nafter\tO\nspeaking\tO\nby\tO\ntelephone\tO\nto\tO\nIschinger\tB-PER\n,\tO\nwho\tO\nhad\tO\nmet\tO\nthe\tO\nofficials\tO\non\tO\na\tO\ntwo-day\tO\nvisit\tO\nto\tO\nMoscow\tO\n.\tO\n\n\"\tO\nThe\tO\nRussian\tO\nside\tO\nconfirmed\tT-1\nthat\tO\nthe\tO\nceasefire\tT-3\nis\tO\nin\tO\nplace\tO\nand\tO\nthey\tO\nwill\tO\nkeep\tO\nto\tO\nit\tO\n,\tO\n\"\tO\nErdmann\tO\ntold\tT-5\nReuters\tO\nafter\tO\nspeaking\tT-2\nby\tO\ntelephone\tO\nto\tO\nIschinger\tO\n,\tO\nwho\tO\nhad\tO\nmet\tO\nthe\tO\nofficials\tT-4\non\tO\na\tO\ntwo-day\tO\nvisit\tT-0\nto\tO\nMoscow\tB-LOC\n.\tO\n\nHe\tO\nreturned\tT-1\nto\tO\nBonn\tB-LOC\non\tO\nThursday\tO\n.\tO\n\nIschinger\tB-PER\nis\tO\nthe\tO\npolitical\tO\ndirector\tO\nof\tO\nBonn\tO\n's\tO\nforeign\tO\nministry\tT-0\n.\tO\n\nIschinger\tT-0\nis\tO\nthe\tO\npolitical\tO\ndirector\tT-1\nof\tT-2\nBonn\tB-LOC\n's\tO\nforeign\tO\nministry\tO\n.\tO\n\nIschinger\tB-PER\nsaid\tT-0\nhe\tO\nmet\tO\nthree\tO\nRussian\tT-2\ndeputy\tO\nforeign\tO\nministers\tO\nand\tO\na\tO\nvice\tO\ndefence\tO\nminister\tO\n,\tO\nwho\tO\nconfirmed\tT-1\nRussian\tO\nForeign\tO\nMinister\tO\nYevgeny\tO\nPrimakov\tO\n's\tO\npledge\tO\nthat\tO\nMoscow\tO\nwould\tO\nseek\tO\na\tO\npolitical\tO\nsolution\tO\nunder\tO\nthe\tO\naegis\tO\nof\tO\nthe\tO\nOrganisation\tO\nfor\tO\nSecurity\tO\nand\tO\nCooperation\tO\nin\tO\nEurope\tO\n(\tO\nOSCE\tO\n)\tO\n.\tO\n\nIschinger\tT-0\nsaid\tO\nhe\tO\nmet\tO\nthree\tT-3\nRussian\tB-MISC\ndeputy\tO\nforeign\tO\nministers\tO\nand\tO\na\tO\nvice\tO\ndefence\tO\nminister\tT-2\n,\tO\nwho\tO\nconfirmed\tT-1\nRussian\tT-4\nForeign\tO\nMinister\tO\nYevgeny\tO\nPrimakov\tO\n's\tO\npledge\tO\nthat\tO\nMoscow\tO\nwould\tO\nseek\tO\na\tO\npolitical\tO\nsolution\tO\nunder\tO\nthe\tO\naegis\tO\nof\tO\nthe\tO\nOrganisation\tO\nfor\tO\nSecurity\tO\nand\tO\nCooperation\tO\nin\tO\nEurope\tO\n(\tO\nOSCE\tO\n)\tO\n.\tO\n\nIschinger\tO\nsaid\tO\nhe\tO\nmet\tO\nthree\tO\nRussian\tO\ndeputy\tO\nforeign\tO\nministers\tO\nand\tO\na\tO\nvice\tO\ndefence\tO\nminister\tO\n,\tO\nwho\tO\nconfirmed\tT-1\nRussian\tB-MISC\nForeign\tT-0\nMinister\tO\nYevgeny\tO\nPrimakov\tO\n's\tO\npledge\tT-2\nthat\tO\nMoscow\tO\nwould\tO\nseek\tO\na\tO\npolitical\tO\nsolution\tO\nunder\tO\nthe\tO\naegis\tO\nof\tO\nthe\tO\nOrganisation\tO\nfor\tO\nSecurity\tO\nand\tO\nCooperation\tO\nin\tO\nEurope\tO\n(\tO\nOSCE\tO\n)\tO\n.\tO\n\nIschinger\tT-0\nsaid\tO\nhe\tO\nmet\tO\nthree\tO\nRussian\tO\ndeputy\tO\nforeign\tO\nministers\tO\nand\tO\na\tO\nvice\tT-3\ndefence\tT-3\nminister\tT-3\n,\tO\nwho\tO\nconfirmed\tO\nRussian\tT-1\nForeign\tO\nMinister\tO\nYevgeny\tB-PER\nPrimakov\tI-PER\n's\tO\npledge\tT-4\nthat\tO\nMoscow\tT-2\nwould\tO\nseek\tO\na\tO\npolitical\tO\nsolution\tO\nunder\tO\nthe\tO\naegis\tO\nof\tO\nthe\tO\nOrganisation\tO\nfor\tO\nSecurity\tO\nand\tO\nCooperation\tO\nin\tO\nEurope\tO\n(\tO\nOSCE\tO\n)\tO\n.\tO\n\nIschinger\tO\nsaid\tO\nhe\tO\nmet\tO\nthree\tO\nRussian\tO\ndeputy\tO\nforeign\tO\nministers\tO\nand\tO\na\tO\nvice\tO\ndefence\tO\nminister\tO\n,\tO\nwho\tO\nconfirmed\tO\nRussian\tT-0\nForeign\tO\nMinister\tO\nYevgeny\tO\nPrimakov\tO\n's\tO\npledge\tO\nthat\tO\nMoscow\tB-LOC\nwould\tT-2\nseek\tO\na\tO\npolitical\tO\nsolution\tO\nunder\tO\nthe\tO\naegis\tO\nof\tO\nthe\tO\nOrganisation\tO\nfor\tO\nSecurity\tO\nand\tO\nCooperation\tO\nin\tO\nEurope\tT-1\n(\tO\nOSCE\tO\n)\tO\n.\tO\n\nIschinger\tO\nsaid\tT-2\nhe\tO\nmet\tO\nthree\tO\nRussian\tO\ndeputy\tO\nforeign\tO\nministers\tO\nand\tO\na\tO\nvice\tO\ndefence\tO\nminister\tO\n,\tO\nwho\tO\nconfirmed\tO\nRussian\tO\nForeign\tO\nMinister\tO\nYevgeny\tO\nPrimakov\tO\n's\tO\npledge\tO\nthat\tO\nMoscow\tT-3\nwould\tO\nseek\tO\na\tO\npolitical\tO\nsolution\tT-4\nunder\tO\nthe\tO\naegis\tT-0\nof\tT-1\nthe\tT-1\nOrganisation\tB-ORG\nfor\tI-ORG\nSecurity\tI-ORG\nand\tI-ORG\nCooperation\tI-ORG\nin\tI-ORG\nEurope\tI-ORG\n(\tO\nOSCE\tO\n)\tO\n.\tO\n\nIschinger\tO\nsaid\tT-2\nhe\tO\nmet\tO\nthree\tO\nRussian\tO\ndeputy\tO\nforeign\tO\nministers\tO\nand\tO\na\tO\nvice\tO\ndefence\tO\nminister\tO\n,\tO\nwho\tO\nconfirmed\tO\nRussian\tO\nForeign\tO\nMinister\tO\nYevgeny\tO\nPrimakov\tO\n's\tO\npledge\tT-3\nthat\tO\nMoscow\tO\nwould\tO\nseek\tT-4\na\tO\npolitical\tO\nsolution\tO\nunder\tO\nthe\tO\naegis\tO\nof\tO\nthe\tO\nOrganisation\tO\nfor\tO\nSecurity\tO\nand\tO\nCooperation\tO\nin\tT-0\nEurope\tT-1\n(\tO\nOSCE\tB-ORG\n)\tO\n.\tO\n\n\"\tO\nThe\tO\nultimatum\tT-2\n(\tO\nto\tT-0\nstorm\tT-0\nGrozny\tB-LOC\n)\tO\nis\tO\nno\tO\nlonger\tO\nan\tO\nissue\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\nquoting\tT-1\nIschinger\tO\n,\tO\nwho\tO\nhad\tO\nbeen\tO\nsent\tO\nto\tO\nMoscow\tT-3\nby\tO\nGerman\tO\nForeign\tO\nMinister\tO\nKlaus\tO\nKinkel\tO\nas\tO\nhis\tO\npersonal\tO\nenvoy\tO\nto\tO\nurge\tO\nan\tO\nend\tO\nto\tO\nMoscow\tO\n's\tO\nmilitary\tO\ncampaign\tO\nin\tO\nthe\tO\nbreakaway\tO\nregion\tO\n.\tO\n\n\"\tO\nThe\tO\nultimatum\tT-3\n(\tO\nto\tO\nstorm\tO\nGrozny\tT-1\n)\tO\nis\tO\nno\tO\nlonger\tO\nan\tO\nissue\tT-4\n,\tO\n\"\tO\nhe\tO\nsaid\tT-0\nquoting\tO\nIschinger\tB-PER\n,\tO\nwho\tO\nhad\tO\nbeen\tO\nsent\tO\nto\tO\nMoscow\tO\nby\tO\nGerman\tO\nForeign\tO\nMinister\tO\nKlaus\tT-2\nKinkel\tT-2\nas\tO\nhis\tO\npersonal\tO\nenvoy\tO\nto\tO\nurge\tO\nan\tO\nend\tO\nto\tO\nMoscow\tO\n's\tO\nmilitary\tO\ncampaign\tO\nin\tO\nthe\tO\nbreakaway\tO\nregion\tO\n.\tO\n\n\"\tO\nThe\tO\nultimatum\tT-1\n(\tO\nto\tO\nstorm\tT-2\nGrozny\tT-2\n)\tO\nis\tO\nno\tO\nlonger\tO\nan\tO\nissue\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tT-4\nquoting\tO\nIschinger\tT-3\n,\tO\nwho\tO\nhad\tO\nbeen\tO\nsent\tT-0\nto\tT-0\nMoscow\tB-LOC\nby\tO\nGerman\tO\nForeign\tO\nMinister\tO\nKlaus\tO\nKinkel\tO\nas\tO\nhis\tO\npersonal\tO\nenvoy\tO\nto\tO\nurge\tO\nan\tO\nend\tO\nto\tO\nMoscow\tO\n's\tO\nmilitary\tO\ncampaign\tO\nin\tO\nthe\tO\nbreakaway\tO\nregion\tO\n.\tO\n\n\"\tO\nThe\tO\nultimatum\tO\n(\tO\nto\tO\nstorm\tO\nGrozny\tO\n)\tO\nis\tO\nno\tO\nlonger\tO\nan\tO\nissue\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tT-0\nquoting\tO\nIschinger\tO\n,\tO\nwho\tO\nhad\tO\nbeen\tO\nsent\tT-1\nto\tO\nMoscow\tO\nby\tO\nGerman\tB-MISC\nForeign\tO\nMinister\tT-3\nKlaus\tO\nKinkel\tO\nas\tO\nhis\tO\npersonal\tO\nenvoy\tO\nto\tO\nurge\tO\nan\tO\nend\tO\nto\tO\nMoscow\tT-2\n's\tO\nmilitary\tO\ncampaign\tO\nin\tO\nthe\tO\nbreakaway\tO\nregion\tO\n.\tO\n\n\"\tO\nThe\tO\nultimatum\tT-0\n(\tO\nto\tO\nstorm\tO\nGrozny\tO\n)\tO\nis\tO\nno\tO\nlonger\tO\nan\tO\nissue\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\nquoting\tO\nIschinger\tO\n,\tO\nwho\tO\nhad\tO\nbeen\tO\nsent\tO\nto\tO\nMoscow\tO\nby\tO\nGerman\tT-1\nForeign\tT-1\nMinister\tT-2\nKlaus\tB-PER\nKinkel\tI-PER\nas\tO\nhis\tO\npersonal\tO\nenvoy\tO\nto\tO\nurge\tO\nan\tO\nend\tO\nto\tO\nMoscow\tO\n's\tO\nmilitary\tO\ncampaign\tO\nin\tO\nthe\tO\nbreakaway\tO\nregion\tO\n.\tO\n\n\"\tO\nThe\tO\nultimatum\tO\n(\tO\nto\tO\nstorm\tO\nGrozny\tO\n)\tO\nis\tO\nno\tO\nlonger\tO\nan\tO\nissue\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tT-1\nquoting\tO\nIschinger\tT-2\n,\tO\nwho\tO\nhad\tO\nbeen\tO\nsent\tT-3\nto\tT-3\nMoscow\tT-3\nby\tO\nGerman\tO\nForeign\tO\nMinister\tO\nKlaus\tO\nKinkel\tO\nas\tO\nhis\tO\npersonal\tO\nenvoy\tO\nto\tO\nurge\tO\nan\tO\nend\tO\nto\tO\nMoscow\tB-LOC\n's\tO\nmilitary\tO\ncampaign\tT-0\nin\tO\nthe\tO\nbreakaway\tT-4\nregion\tT-4\n.\tO\n\nIschinger\tB-PER\nsaid\tT-0\nthe\tO\nthreat\tO\nof\tO\na\tO\nmajor\tO\nassault\tT-1\nto\tO\ntake\tO\nGrozny\tO\nhad\tO\nbeen\tO\nthe\tO\nunauthorised\tO\ninitiative\tO\nof\tO\nthe\tO\ncommanding\tO\ngeneral\tO\nand\tO\nnot\tO\nMoscow\tT-2\n's\tO\nintention\tO\n.\tO\n\nIschinger\tO\nsaid\tO\nthe\tO\nthreat\tO\nof\tO\na\tO\nmajor\tO\nassault\tO\nto\tO\ntake\tO\nGrozny\tB-LOC\nhad\tT-1\nbeen\tT-1\nthe\tO\nunauthorised\tO\ninitiative\tT-2\nof\tO\nthe\tO\ncommanding\tT-3\ngeneral\tO\nand\tO\nnot\tO\nMoscow\tT-0\n's\tT-0\nintention\tO\n.\tO\n\nIschinger\tT-0\nsaid\tT-3\nthe\tO\nthreat\tO\nof\tO\na\tO\nmajor\tO\nassault\tO\nto\tO\ntake\tO\nGrozny\tT-1\nhad\tO\nbeen\tO\nthe\tO\nunauthorised\tO\ninitiative\tO\nof\tO\nthe\tO\ncommanding\tT-2\ngeneral\tO\nand\tO\nnot\tO\nMoscow\tB-LOC\n's\tO\nintention\tO\n.\tO\n\nThe\tO\nofficials\tO\nhad\tO\nbeen\tO\npositive\tT-1\nabout\tO\nKinkel\tB-PER\n's\tO\nrequest\tT-2\non\tO\nWednesday\tO\nthat\tO\nPresident\tT-0\nBoris\tT-0\nYeltsin\tT-0\n's\tO\nsecurity\tO\nchief\tO\nAlexander\tO\nLebed\tO\nshould\tO\n,\tO\non\tO\nhis\tO\nreturn\tT-3\nto\tO\nMoscow\tO\n,\tO\nmeet\tO\nTim\tO\nGoldiman\tO\n,\tO\nthe\tO\nOSCE\tO\nrepresentative\tT-4\nresponsible\tO\nfor\tO\nChechnya\tO\n,\tO\nhe\tO\nsaid\tO\n.\tO\n\nThe\tO\nofficials\tO\nhad\tO\nbeen\tO\npositive\tO\nabout\tO\nKinkel\tO\n's\tO\nrequest\tO\non\tO\nWednesday\tO\nthat\tO\nPresident\tO\nBoris\tB-PER\nYeltsin\tI-PER\n's\tO\nsecurity\tT-0\nchief\tO\nAlexander\tO\nLebed\tO\nshould\tO\n,\tO\non\tO\nhis\tO\nreturn\tO\nto\tO\nMoscow\tO\n,\tO\nmeet\tO\nTim\tO\nGoldiman\tO\n,\tO\nthe\tO\nOSCE\tO\nrepresentative\tT-1\nresponsible\tO\nfor\tO\nChechnya\tO\n,\tO\nhe\tO\nsaid\tT-2\n.\tO\n\nThe\tO\nofficials\tO\nhad\tO\nbeen\tO\npositive\tO\nabout\tO\nKinkel\tT-0\n's\tO\nrequest\tO\non\tO\nWednesday\tO\nthat\tO\nPresident\tT-1\nBoris\tT-1\nYeltsin\tT-1\n's\tO\nsecurity\tT-6\nchief\tT-6\nAlexander\tB-PER\nLebed\tI-PER\nshould\tT-5\n,\tO\non\tO\nhis\tO\nreturn\tO\nto\tO\nMoscow\tT-2\n,\tO\nmeet\tO\nTim\tT-3\nGoldiman\tT-3\n,\tO\nthe\tO\nOSCE\tO\nrepresentative\tO\nresponsible\tO\nfor\tO\nChechnya\tT-4\n,\tO\nhe\tO\nsaid\tO\n.\tO\n\nThe\tO\nofficials\tO\nhad\tO\nbeen\tO\npositive\tO\nabout\tO\nKinkel\tT-2\n's\tO\nrequest\tO\non\tO\nWednesday\tO\nthat\tO\nPresident\tO\nBoris\tO\nYeltsin\tO\n's\tO\nsecurity\tT-0\nchief\tO\nAlexander\tO\nLebed\tO\nshould\tO\n,\tO\non\tO\nhis\tO\nreturn\tO\nto\tO\nMoscow\tB-LOC\n,\tO\nmeet\tO\nTim\tT-4\nGoldiman\tT-4\n,\tO\nthe\tO\nOSCE\tO\nrepresentative\tO\nresponsible\tO\nfor\tO\nChechnya\tT-3\n,\tO\nhe\tT-1\nsaid\tT-1\n.\tO\n\nThe\tT-0\nofficials\tT-0\nhad\tO\nbeen\tO\npositive\tT-1\nabout\tO\nKinkel\tO\n's\tO\nrequest\tO\non\tO\nWednesday\tO\nthat\tO\nPresident\tO\nBoris\tO\nYeltsin\tO\n's\tO\nsecurity\tO\nchief\tO\nAlexander\tO\nLebed\tO\nshould\tO\n,\tO\non\tO\nhis\tO\nreturn\tO\nto\tO\nMoscow\tO\n,\tO\nmeet\tO\nTim\tB-PER\nGoldiman\tI-PER\n,\tO\nthe\tO\nOSCE\tO\nrepresentative\tT-2\nresponsible\tO\nfor\tO\nChechnya\tO\n,\tO\nhe\tO\nsaid\tO\n.\tO\n\nThe\tO\nofficials\tT-1\nhad\tO\nbeen\tO\npositive\tO\nabout\tO\nKinkel\tT-2\n's\tO\nrequest\tO\non\tO\nWednesday\tO\nthat\tO\nPresident\tO\nBoris\tO\nYeltsin\tO\n's\tO\nsecurity\tO\nchief\tO\nAlexander\tO\nLebed\tO\nshould\tO\n,\tO\non\tO\nhis\tO\nreturn\tO\nto\tO\nMoscow\tO\n,\tO\nmeet\tT-3\nTim\tO\nGoldiman\tO\n,\tO\nthe\tO\nOSCE\tB-ORG\nrepresentative\tT-0\nresponsible\tO\nfor\tO\nChechnya\tO\n,\tO\nhe\tO\nsaid\tO\n.\tO\n\nThe\tO\nofficials\tO\nhad\tO\nbeen\tO\npositive\tO\nabout\tO\nKinkel\tO\n's\tO\nrequest\tO\non\tO\nWednesday\tO\nthat\tO\nPresident\tO\nBoris\tO\nYeltsin\tO\n's\tO\nsecurity\tO\nchief\tO\nAlexander\tT-0\nLebed\tT-0\nshould\tO\n,\tO\non\tO\nhis\tO\nreturn\tO\nto\tO\nMoscow\tT-1\n,\tO\nmeet\tO\nTim\tO\nGoldiman\tO\n,\tO\nthe\tO\nOSCE\tT-2\nrepresentative\tO\nresponsible\tT-3\nfor\tO\nChechnya\tB-LOC\n,\tO\nhe\tO\nsaid\tO\n.\tO\n\nIndia\tB-LOC\nsays\tT-0\nsees\tO\nno\tO\narms\tT-3\nrace\tO\nwith\tO\nChina\tT-1\n,\tO\nPakistan\tT-2\n.\tO\n\nIndia\tO\nsays\tO\nsees\tO\nno\tO\narms\tT-0\nrace\tT-0\nwith\tO\nChina\tB-LOC\n,\tO\nPakistan\tO\n.\tO\n\nIndia\tT-1\nsays\tO\nsees\tO\nno\tO\narms\tO\nrace\tT-0\nwith\tO\nChina\tO\n,\tO\nPakistan\tB-LOC\n.\tO\n\nIndia\tB-LOC\nsaid\tT-1\non\tO\nThursday\tO\nthat\tO\nits\tO\nopposition\tO\nto\tO\na\tO\nglobal\tO\nnuclear\tO\ntest\tO\nban\tO\ntreaty\tT-0\ndid\tO\nnot\tO\nmean\tO\nNew\tO\nDelhi\tT-2\nintended\tO\nto\tO\nenter\tO\ninto\tO\nan\tO\narms\tO\nrace\tO\nwith\tO\nneighbouring\tO\nPakistan\tT-3\nand\tO\nChina\tT-4\n.\tT-0\n\nIndia\tO\nsaid\tO\non\tO\nThursday\tO\nthat\tO\nits\tO\nopposition\tO\nto\tO\na\tO\nglobal\tO\nnuclear\tO\ntest\tO\nban\tO\ntreaty\tO\ndid\tO\nnot\tO\nmean\tO\nNew\tB-LOC\nDelhi\tI-LOC\nintended\tO\nto\tO\nenter\tO\ninto\tO\nan\tO\narms\tO\nrace\tO\nwith\tO\nneighbouring\tT-0\nPakistan\tO\nand\tO\nChina\tO\n.\tO\n\nIndia\tT-0\nsaid\tO\non\tO\nThursday\tO\nthat\tO\nits\tO\nopposition\tO\nto\tO\na\tO\nglobal\tT-1\nnuclear\tT-1\ntest\tT-1\nban\tT-1\ntreaty\tT-1\ndid\tO\nnot\tO\nmean\tO\nNew\tO\nDelhi\tO\nintended\tO\nto\tO\nenter\tO\ninto\tO\nan\tO\narms\tO\nrace\tO\nwith\tO\nneighbouring\tT-2\nPakistan\tB-LOC\nand\tO\nChina\tO\n.\tO\n\nIndia\tO\nsaid\tT-1\non\tO\nThursday\tO\nthat\tO\nits\tO\nopposition\tO\nto\tO\na\tO\nglobal\tO\nnuclear\tO\ntest\tO\nban\tO\ntreaty\tO\ndid\tO\nnot\tO\nmean\tO\nNew\tO\nDelhi\tO\nintended\tT-2\nto\tO\nenter\tO\ninto\tO\nan\tO\narms\tO\nrace\tO\nwith\tO\nneighbouring\tO\nPakistan\tO\nand\tT-0\nChina\tB-LOC\n.\tO\n\nForeign\tT-0\nMinister\tT-0\nI.K.\tB-PER\nGujral\tI-PER\nwas\tO\nasked\tT-1\nat\tO\na\tO\nnews\tO\nconference\tO\nif\tO\nIndia\tO\n's\tO\ndecision\tO\nto\tO\nblock\tO\nadoption\tO\nof\tO\nthe\tO\naccord\tO\nin\tO\nGeneva\tO\nwould\tO\nlead\tO\nto\tO\nan\tO\narms\tO\nrace\tO\nwith\tO\nPakistan\tO\nand\tO\nChina\tO\n.\tO\n\nForeign\tO\nMinister\tO\nI.K.\tT-3\nGujral\tT-3\nwas\tO\nasked\tT-1\nat\tO\na\tO\nnews\tO\nconference\tT-4\nif\tT-0\nIndia\tB-LOC\n's\tO\ndecision\tT-2\nto\tO\nblock\tO\nadoption\tO\nof\tO\nthe\tO\naccord\tO\nin\tO\nGeneva\tT-5\nwould\tO\nlead\tO\nto\tO\nan\tO\narms\tO\nrace\tO\nwith\tO\nPakistan\tT-6\nand\tO\nChina\tT-7\n.\tO\n\nForeign\tT-0\nMinister\tT-0\nI.K.\tT-3\nGujral\tT-3\nwas\tO\nasked\tO\nat\tO\na\tO\nnews\tO\nconference\tO\nif\tO\nIndia\tT-2\n's\tT-2\ndecision\tT-2\nto\tO\nblock\tT-4\nadoption\tT-4\nof\tO\nthe\tO\naccord\tO\nin\tT-1\nGeneva\tB-LOC\nwould\tO\nlead\tO\nto\tO\nan\tO\narms\tO\nrace\tO\nwith\tO\nPakistan\tO\nand\tO\nChina\tO\n.\tO\n\nForeign\tO\nMinister\tO\nI.K.\tO\nGujral\tO\nwas\tO\nasked\tT-0\nat\tO\na\tO\nnews\tO\nconference\tT-1\nif\tO\nIndia\tO\n's\tO\ndecision\tO\nto\tO\nblock\tT-2\nadoption\tO\nof\tO\nthe\tO\naccord\tO\nin\tO\nGeneva\tO\nwould\tO\nlead\tO\nto\tO\nan\tO\narms\tO\nrace\tO\nwith\tT-3\nPakistan\tB-LOC\nand\tO\nChina\tO\n.\tO\n\nForeign\tO\nMinister\tO\nI.K.\tO\nGujral\tO\nwas\tO\nasked\tO\nat\tO\na\tO\nnews\tO\nconference\tO\nif\tO\nIndia\tO\n's\tO\ndecision\tO\nto\tO\nblock\tO\nadoption\tO\nof\tO\nthe\tO\naccord\tO\nin\tO\nGeneva\tO\nwould\tO\nlead\tO\nto\tO\nan\tO\narms\tO\nrace\tT-0\nwith\tO\nPakistan\tT-2\nand\tT-1\nChina\tB-LOC\n.\tO\n\n\"\tO\nI\tO\ndo\tO\nn't\tO\nsee\tO\nthat\tO\npossibility\tO\nbecause\tO\nIndia\tB-LOC\nis\tO\nnot\tO\nentering\tO\ninto\tT-0\nany\tO\narms\tO\nrace\tT-1\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\"\tO\n\nChina\tB-LOC\n,\tO\nalong\tT-4\nwith\tT-4\nBritain\tT-0\n,\tO\nFrance\tT-1\n,\tO\nRussia\tT-2\nand\tO\nthe\tO\nUnited\tT-3\nStates\tT-3\n,\tO\nis\tO\na\tO\ndeclared\tT-5\nnuclear\tO\npower\tO\n.\tO\n\nChina\tO\n,\tO\nalong\tT-2\nwith\tT-2\nBritain\tB-LOC\n,\tO\nFrance\tO\n,\tO\nRussia\tO\nand\tO\nthe\tO\nUnited\tO\nStates\tO\n,\tO\nis\tO\na\tO\ndeclared\tT-1\nnuclear\tT-0\npower\tT-0\n.\tO\n\nChina\tO\n,\tO\nalong\tT-0\nwith\tO\nBritain\tO\n,\tO\nFrance\tB-LOC\n,\tO\nRussia\tT-3\nand\tO\nthe\tO\nUnited\tO\nStates\tO\n,\tO\nis\tT-2\na\tT-2\ndeclared\tT-2\nnuclear\tO\npower\tT-4\n.\tO\n\nChina\tT-2\n,\tO\nalong\tO\nwith\tO\nBritain\tT-3\n,\tO\nFrance\tT-4\n,\tO\nRussia\tB-LOC\nand\tO\nthe\tO\nUnited\tT-0\nStates\tT-0\n,\tO\nis\tO\na\tO\ndeclared\tT-5\nnuclear\tT-1\npower\tT-1\n.\tO\n\nChina\tO\n,\tO\nalong\tO\nwith\tO\nBritain\tO\n,\tO\nFrance\tO\n,\tO\nRussia\tT-0\nand\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\n,\tO\nis\tO\na\tO\ndeclared\tO\nnuclear\tT-1\npower\tT-1\n.\tO\n\nIndia\tB-LOC\ncarried\tT-0\nout\tO\na\tO\nnuclear\tT-2\ntest\tO\nin\tO\n1974\tO\nbut\tO\nsays\tT-1\nit\tO\nhas\tO\nnot\tO\nbuilt\tO\nthe\tO\nbomb\tO\n.\tO\n\nExperts\tT-1\nbelieve\tO\nboth\tO\nIndia\tB-LOC\nand\tO\nPakistan\tO\ncould\tT-0\nquickly\tO\nassemble\tO\nnuclear\tO\nweapons\tO\n.\tO\n\nExperts\tO\nbelieve\tT-1\nboth\tO\nIndia\tT-0\nand\tT-0\nPakistan\tB-LOC\ncould\tO\nquickly\tO\nassemble\tO\nnuclear\tO\nweapons\tO\n.\tO\n\nGujral\tB-PER\nsaid\tT-2\nhe\tT-0\ndid\tO\nnot\tO\nexpect\tO\nIndia\tT-1\n's\tT-1\nveto\tT-1\nof\tO\nthe\tO\nComprehensive\tO\nTest\tO\nBan\tO\nTreaty\tO\n(\tO\nCTBT\tO\n)\tO\nto\tO\ndamage\tO\nbilateral\tO\nties\tO\nwith\tO\nother\tO\nnations\tO\n.\tO\n\nGujral\tT-0\nsaid\tO\nhe\tO\ndid\tO\nnot\tO\nexpect\tT-3\nIndia\tB-LOC\n's\tO\nveto\tT-4\nof\tO\nthe\tO\nComprehensive\tT-1\nTest\tO\nBan\tO\nTreaty\tO\n(\tO\nCTBT\tO\n)\tO\nto\tO\ndamage\tO\nbilateral\tT-2\nties\tO\nwith\tO\nother\tO\nnations\tO\n.\tO\n\nGujral\tT-0\nsaid\tT-0\nhe\tO\ndid\tO\nnot\tO\nexpect\tO\nIndia\tT-1\n's\tT-1\nveto\tT-1\nof\tO\nthe\tO\nComprehensive\tB-MISC\nTest\tI-MISC\nBan\tI-MISC\nTreaty\tI-MISC\n(\tO\nCTBT\tT-2\n)\tO\nto\tT-3\ndamage\tT-3\nbilateral\tO\nties\tO\nwith\tO\nother\tO\nnations\tO\n.\tO\n\nGujral\tT-3\nsaid\tT-0\nhe\tO\ndid\tO\nnot\tO\nexpect\tO\nIndia\tO\n's\tO\nveto\tO\nof\tO\nthe\tO\nComprehensive\tT-4\nTest\tT-4\nBan\tT-4\nTreaty\tT-4\n(\tO\nCTBT\tB-MISC\n)\tO\nto\tO\ndamage\tT-1\nbilateral\tO\nties\tO\nwith\tO\nother\tO\nnations\tT-2\n.\tO\n\nGujral\tB-PER\nsaid\tO\nIndia\tT-0\nwould\tO\nre-examine\tO\nits\tO\nposition\tT-1\nif\tO\nthe\tO\ntreaty\tO\n,\tO\nparticularly\tO\na\tO\nclause\tO\nproviding\tO\nfor\tO\nits\tO\nentry\tO\ninto\tO\nforce\tO\n,\tO\nwas\tO\nmodified\tO\n.\tO\n\nGujral\tT-0\nsaid\tT-4\nIndia\tB-LOC\nwould\tO\nre-examine\tT-2\nits\tO\nposition\tO\nif\tO\nthe\tO\ntreaty\tT-1\n,\tO\nparticularly\tO\na\tO\nclause\tO\nproviding\tO\nfor\tO\nits\tO\nentry\tO\ninto\tO\nforce\tO\n,\tO\nwas\tT-3\nmodified\tT-3\n.\tT-3\n\nAsked\tT-0\nwhat\tT-0\nIndia\tB-LOC\nwould\tT-2\ndo\tT-2\nif\tO\nthe\tO\npact\tT-3\nwere\tO\nforwarded\tO\nto\tO\nthe\tO\nUnited\tT-4\nNations\tT-4\nGeneral\tT-4\nAssembly\tT-4\n,\tO\nGujral\tT-1\nsaid\tO\n:\tO\n\"\tO\nThat\tO\nbridge\tO\nI\tO\nwill\tO\ncross\tO\nwhen\tO\nI\tO\ncome\tO\nto\tO\nit\tO\n.\tO\n\"\tO\n\nAsked\tT-0\nwhat\tO\nIndia\tO\nwould\tO\ndo\tO\nif\tO\nthe\tO\npact\tO\nwere\tO\nforwarded\tT-2\nto\tO\nthe\tO\nUnited\tB-ORG\nNations\tI-ORG\nGeneral\tI-ORG\nAssembly\tI-ORG\n,\tO\nGujral\tO\nsaid\tT-1\n:\tO\n\"\tO\nThat\tO\nbridge\tO\nI\tO\nwill\tO\ncross\tO\nwhen\tO\nI\tO\ncome\tO\nto\tO\nit\tO\n.\tO\n\"\tO\n\nAsked\tT-3\nwhat\tO\nIndia\tO\nwould\tO\ndo\tO\nif\tO\nthe\tO\npact\tO\nwere\tO\nforwarded\tO\nto\tO\nthe\tO\nUnited\tO\nNations\tO\nGeneral\tO\nAssembly\tT-0\n,\tO\nGujral\tB-PER\nsaid\tT-4\n:\tO\n\"\tO\nThat\tO\nbridge\tT-1\nI\tO\nwill\tO\ncross\tT-2\nwhen\tO\nI\tO\ncome\tO\nto\tO\nit\tO\n.\tO\n\"\tO\n\nIn\tO\na\tO\nwritten\tT-2\nstatement\tT-2\nreleased\tT-0\nat\tO\nthe\tO\nnews\tO\nconference\tO\n,\tO\nGujral\tB-PER\nreiterated\tT-3\nIndia\tO\n's\tO\nobjections\tO\nto\tO\nthe\tO\ntreaty\tO\n,\tO\nunder\tO\nnegotiation\tO\nat\tO\nthe\tO\nConference\tT-1\non\tO\nDisarmament\tO\nin\tO\nGeneva\tO\n.\tO\n\nIn\tO\na\tO\nwritten\tO\nstatement\tO\nreleased\tO\nat\tO\nthe\tO\nnews\tO\nconference\tO\n,\tO\nGujral\tT-0\nreiterated\tT-1\nIndia\tB-LOC\n's\tT-2\nobjections\tT-2\nto\tT-2\nthe\tT-2\ntreaty\tT-2\n,\tO\nunder\tO\nnegotiation\tO\nat\tO\nthe\tO\nConference\tO\non\tO\nDisarmament\tO\nin\tO\nGeneva\tO\n.\tO\n\nIn\tO\na\tO\nwritten\tO\nstatement\tO\nreleased\tO\nat\tO\nthe\tO\nnews\tO\nconference\tO\n,\tO\nGujral\tO\nreiterated\tT-0\nIndia\tO\n's\tO\nobjections\tO\nto\tO\nthe\tO\ntreaty\tO\n,\tO\nunder\tO\nnegotiation\tO\nat\tO\nthe\tO\nConference\tB-MISC\non\tI-MISC\nDisarmament\tI-MISC\nin\tT-2\nGeneva\tT-2\n.\tO\n\nIn\tO\na\tO\nwritten\tT-1\nstatement\tO\nreleased\tT-2\nat\tO\nthe\tO\nnews\tO\nconference\tO\n,\tO\nGujral\tO\nreiterated\tO\nIndia\tO\n's\tO\nobjections\tO\nto\tO\nthe\tO\ntreaty\tO\n,\tO\nunder\tO\nnegotiation\tT-0\nat\tO\nthe\tO\nConference\tT-3\non\tT-3\nDisarmament\tT-3\nin\tO\nGeneva\tB-LOC\n.\tO\n\nGujral\tB-PER\nsaid\tO\nIndia\tT-0\nhad\tO\nnational\tT-1\nsecurity\tT-1\nconcerns\tT-1\nthat\tO\nmade\tO\nit\tO\nimpossible\tO\nfor\tO\nNew\tO\nDelhi\tO\nto\tO\nsign\tT-2\nthe\tT-2\nCTBT\tT-2\n.\tO\n\nGujral\tT-0\nsaid\tO\nIndia\tB-LOC\nhad\tT-1\nnational\tT-2\nsecurity\tT-2\nconcerns\tO\nthat\tO\nmade\tO\nit\tO\nimpossible\tO\nfor\tO\nNew\tO\nDelhi\tO\nto\tO\nsign\tO\nthe\tO\nCTBT\tO\n.\tO\n\nGujral\tO\nsaid\tT-0\nIndia\tO\nhad\tO\nnational\tT-1\nsecurity\tO\nconcerns\tO\nthat\tO\nmade\tO\nit\tO\nimpossible\tO\nfor\tO\nNew\tB-LOC\nDelhi\tI-LOC\nto\tO\nsign\tT-2\nthe\tT-2\nCTBT\tT-2\n.\tO\n\nGujral\tT-1\nsaid\tT-0\nIndia\tO\nhad\tO\nnational\tO\nsecurity\tO\nconcerns\tO\nthat\tO\nmade\tO\nit\tO\nimpossible\tT-3\nfor\tO\nNew\tT-2\nDelhi\tT-2\nto\tO\nsign\tO\nthe\tO\nCTBT\tB-MISC\n.\tO\n\n\"\tO\nOur\tO\nsecurity\tT-1\nconcerns\tO\noblige\tO\nus\tO\nto\tO\nmaintain\tO\nour\tO\nnuclear\tT-2\noption\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n,\tO\nadding\tO\nthat\tO\nIndia\tB-LOC\nhad\tO\nexercised\tT-0\nrestraint\tO\nin\tO\nnot\tO\ncarrying\tO\nout\tO\nany\tO\nnuclear\tO\ntests\tO\nsince\tO\nthe\tO\ncountry\tO\n's\tO\nlone\tO\ntest\tO\nblast\tO\nin\tO\n1974\tO\n.\tO\n\nBritain\tB-LOC\nsays\tT-1\ndeath\tO\nof\tO\nits\tO\ncitizen\tT-0\nwill\tO\nsour\tO\nties\tO\n.\tO\n\nA\tO\nBritish\tB-MISC\nminister\tT-1\nexpressed\tO\nhis\tO\ngovernment\tO\n's\tO\nofficial\tO\ndisquiet\tO\non\tO\nThursday\tO\nat\tO\nthe\tO\nrecent\tO\ndeath\tO\nof\tO\na\tO\nBritish\tO\ncitizen\tO\nof\tO\nBangladeshi\tO\norigin\tO\nat\tO\nDhaka\tO\nairport\tT-0\n.\tO\n\nA\tO\nBritish\tO\nminister\tO\nexpressed\tT-0\nhis\tO\ngovernment\tO\n's\tO\nofficial\tT-1\ndisquiet\tT-4\non\tO\nThursday\tO\nat\tO\nthe\tO\nrecent\tO\ndeath\tT-2\nof\tO\na\tO\nBritish\tB-MISC\ncitizen\tT-3\nof\tO\nBangladeshi\tO\norigin\tO\nat\tO\nDhaka\tT-5\nairport\tT-5\n.\tO\n\nA\tO\nBritish\tO\nminister\tT-0\nexpressed\tO\nhis\tO\ngovernment\tT-2\n's\tO\nofficial\tO\ndisquiet\tO\non\tO\nThursday\tO\nat\tO\nthe\tO\nrecent\tO\ndeath\tT-1\nof\tO\na\tO\nBritish\tO\ncitizen\tO\nof\tO\nBangladeshi\tB-MISC\norigin\tO\nat\tO\nDhaka\tO\nairport\tO\n.\tO\n\nA\tO\nBritish\tO\nminister\tO\nexpressed\tO\nhis\tO\ngovernment\tO\n's\tO\nofficial\tO\ndisquiet\tO\non\tO\nThursday\tO\nat\tO\nthe\tO\nrecent\tO\ndeath\tO\nof\tO\na\tO\nBritish\tO\ncitizen\tO\nof\tO\nBangladeshi\tT-2\norigin\tO\nat\tT-0\nDhaka\tB-LOC\nairport\tT-1\n.\tO\n\n\"\tO\nI\tO\nhave\tO\ntold\tO\nBangladesh\tB-LOC\nleaders\tT-3\nthat\tO\nBritish\tO\ngoverment\tT-2\nhas\tO\nattached\tO\nserious\tO\nimportance\tO\nto\tO\nthe\tO\nresolution\tT-0\nof\tO\nthe\tO\ntragic\tO\ndeath\tO\nof\tO\nSiraj\tO\nMia\tO\n,\tO\n\"\tO\nUnder-Secretary\tO\nof\tO\nState\tO\nfor\tO\nForeign\tO\nand\tO\nCommonwealth\tT-1\nAffairs\tT-1\nLiam\tT-1\nFox\tT-1\nFox\tT-1\n,\tO\ntold\tO\nreporters\tO\n.\tO\n\n\"\tO\nI\tO\nhave\tO\ntold\tO\nBangladesh\tT-1\nleaders\tO\nthat\tO\nBritish\tB-MISC\ngoverment\tT-0\nhas\tO\nattached\tO\nserious\tO\nimportance\tO\nto\tO\nthe\tO\nresolution\tO\nof\tO\nthe\tO\ntragic\tO\ndeath\tO\nof\tO\nSiraj\tT-2\nMia\tT-2\n,\tO\n\"\tO\nUnder-Secretary\tO\nof\tO\nState\tO\nfor\tO\nForeign\tO\nand\tO\nCommonwealth\tO\nAffairs\tO\nLiam\tT-3\nFox\tT-3\nFox\tT-3\n,\tO\ntold\tO\nreporters\tO\n.\tO\n\n\"\tO\nI\tO\nhave\tO\ntold\tO\nBangladesh\tO\nleaders\tO\nthat\tO\nBritish\tT-0\ngoverment\tT-0\nhas\tO\nattached\tO\nserious\tO\nimportance\tO\nto\tO\nthe\tO\nresolution\tO\nof\tO\nthe\tO\ntragic\tO\ndeath\tO\nof\tO\nSiraj\tB-PER\nMia\tI-PER\n,\tO\n\"\tO\nUnder-Secretary\tO\nof\tO\nState\tO\nfor\tO\nForeign\tO\nand\tO\nCommonwealth\tO\nAffairs\tO\nLiam\tO\nFox\tO\nFox\tO\n,\tO\ntold\tO\nreporters\tO\n.\tO\n\n\"\tO\nI\tO\nhave\tO\ntold\tO\nBangladesh\tT-0\nleaders\tO\nthat\tO\nBritish\tO\ngoverment\tO\nhas\tO\nattached\tO\nserious\tO\nimportance\tO\nto\tO\nthe\tO\nresolution\tO\nof\tO\nthe\tO\ntragic\tO\ndeath\tO\nof\tO\nSiraj\tT-1\nMia\tT-1\n,\tO\n\"\tO\nUnder-Secretary\tT-4\nof\tT-4\nState\tT-4\nfor\tT-4\nForeign\tT-4\nand\tT-3\nCommonwealth\tB-ORG\nAffairs\tO\nLiam\tT-2\nFox\tT-2\nFox\tT-2\n,\tO\ntold\tO\nreporters\tO\n.\tO\n\n\"\tO\nI\tO\nhave\tO\ntold\tO\nBangladesh\tO\nleaders\tO\nthat\tO\nBritish\tO\ngoverment\tT-1\nhas\tO\nattached\tO\nserious\tO\nimportance\tO\nto\tO\nthe\tO\nresolution\tO\nof\tO\nthe\tO\ntragic\tO\ndeath\tO\nof\tO\nSiraj\tO\nMia\tO\n,\tO\n\"\tO\nUnder-Secretary\tT-0\nof\tO\nState\tO\nfor\tO\nForeign\tO\nand\tO\nCommonwealth\tO\nAffairs\tO\nLiam\tB-PER\nFox\tI-PER\nFox\tI-PER\n,\tO\ntold\tO\nreporters\tT-2\n.\tO\n\nSiraj\tB-PER\nMia\tI-PER\ndied\tO\nat\tO\nDhaka\tO\nairport\tO\non\tO\nMay\tO\n9\tO\nduring\tO\ninterogation\tT-0\nby\tO\ncustoms\tO\nofficials\tO\nafter\tO\narriving\tO\nfrom\tO\nLondon\tO\n.\tO\n\nSiraj\tT-1\nMia\tT-1\ndied\tO\nat\tT-0\nDhaka\tB-LOC\nairport\tO\non\tO\nMay\tO\n9\tO\nduring\tO\ninterogation\tO\nby\tO\ncustoms\tO\nofficials\tO\nafter\tO\narriving\tO\nfrom\tO\nLondon\tO\n.\tO\n\nSiraj\tO\nMia\tO\ndied\tT-1\nat\tO\nDhaka\tO\nairport\tT-0\non\tO\nMay\tO\n9\tO\nduring\tO\ninterogation\tT-3\nby\tO\ncustoms\tO\nofficials\tO\nafter\tO\narriving\tT-2\nfrom\tO\nLondon\tB-LOC\n.\tO\n\nFox\tB-PER\n,\tO\nwho\tO\narrived\tO\nin\tO\nBangladesh\tO\non\tO\nTuesday\tO\non\tO\nfour-day\tO\nvisit\tO\n,\tO\nsaid\tT-0\nBritain\tT-2\nwanted\tO\nDhaka\tT-3\nto\tO\nact\tO\nseriously\tT-1\non\tO\nthe\tO\ncase\tO\n.\tO\n\nFox\tT-0\n,\tO\nwho\tO\narrived\tT-1\nin\tO\nBangladesh\tB-LOC\non\tO\nTuesday\tO\non\tO\nfour-day\tO\nvisit\tO\n,\tO\nsaid\tO\nBritain\tO\nwanted\tO\nDhaka\tO\nto\tO\nact\tO\nseriously\tO\non\tO\nthe\tO\ncase\tO\n.\tO\n\nFox\tO\n,\tO\nwho\tO\narrived\tT-2\nin\tO\nBangladesh\tT-0\non\tO\nTuesday\tO\non\tO\nfour-day\tO\nvisit\tT-4\n,\tO\nsaid\tO\nBritain\tB-LOC\nwanted\tO\nDhaka\tO\nto\tO\nact\tT-3\nseriously\tT-1\non\tO\nthe\tO\ncase\tO\n.\tO\n\nFox\tO\n,\tO\nwho\tO\narrived\tO\nin\tT-0\nBangladesh\tT-1\non\tO\nTuesday\tO\non\tO\nfour-day\tO\nvisit\tO\n,\tO\nsaid\tO\nBritain\tO\nwanted\tO\nDhaka\tB-LOC\nto\tO\nact\tO\nseriously\tO\non\tO\nthe\tO\ncase\tO\n.\tO\n\nthis\tO\nis\tO\nan\tO\nimportant\tO\nissue\tT-0\nin\tO\nour\tO\nrelationship\tT-2\n\"\tO\n,\tO\nsaid\tT-1\nFox\tB-PER\n,\tO\nwho\tT-3\nis\tO\ndue\tO\nto\tO\nleave\tO\nfor\tO\nNepal\tO\non\tO\nFriday\tO\n.\tO\n\nthis\tO\nis\tO\nan\tO\nimportant\tO\nissue\tO\nin\tO\nour\tO\nrelationship\tO\n\"\tO\n,\tO\nsaid\tO\nFox\tO\n,\tO\nwho\tO\nis\tO\ndue\tO\nto\tO\nleave\tO\nfor\tT-0\nNepal\tB-LOC\non\tO\nFriday\tO\n.\tO\n\nHe\tO\nsaid\tT-0\nthe\tT-2\nMia\tB-PER\n's\tO\nissue\tT-3\nhad\tO\nbeen\tO\nraised\tT-1\nin\tO\nthe\tO\nHouse\tO\nof\tO\nCommons\tO\n.\tO\n\nHe\tO\nsaid\tO\nthe\tO\nMia\tO\n's\tO\nissue\tO\nhad\tO\nbeen\tO\nraised\tT-0\nin\tT-0\nthe\tO\nHouse\tB-ORG\nof\tI-ORG\nCommons\tI-ORG\n.\tO\n\nFox\tB-PER\nsaid\tO\nhe\tO\nhad\tO\nbrought\tO\nup\tO\nthe\tO\nissue\tO\nat\tO\nevery\tO\nmeeting\tT-0\nhe\tO\nhad\tO\nhad\tO\nwith\tO\ngovernment\tO\nleaders\tO\nin\tO\nDhaka\tO\n.\tO\n\nFox\tO\nsaid\tT-1\nhe\tO\nhad\tO\nbrought\tO\nup\tO\nthe\tO\nissue\tO\nat\tO\nevery\tO\nmeeting\tO\nhe\tO\nhad\tO\nhad\tO\nwith\tO\ngovernment\tO\nleaders\tO\nin\tT-0\nDhaka\tB-LOC\n.\tO\n\nHe\tO\nsaid\tO\nthe\tT-1\nBangladesh\tB-LOC\ngovernment\tT-0\nhad\tO\nassured\tO\nhim\tO\nit\tO\nwas\tO\ntaking\tO\nthe\tO\nmatter\tO\nseriously\tO\n.\tO\n\n\"\tO\nThe\tO\nBritish\tB-MISC\ngovernment\tT-0\nwants\tT-1\na\tO\nthorough\tO\ninvestigation\tO\nand\tO\na\tO\njust\tO\noutcome\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\nFox\tB-PER\nsaid\tO\nthe\tO\nBritish\tT-0\ngovernment\tT-1\nwanted\tO\nan\tO\nend\tO\nto\tO\nthe\tO\nalleged\tO\nharassment\tT-2\nof\tO\nits\tO\nnationals\tO\nat\tO\nDhaka\tO\nairport\tO\nby\tO\ncustoms\tO\nofficials\tO\n.\tO\n\nFox\tT-0\nsaid\tO\nthe\tO\nBritish\tB-MISC\ngovernment\tT-2\nwanted\tT-3\nan\tO\nend\tO\nto\tO\nthe\tO\nalleged\tO\nharassment\tO\nof\tO\nits\tO\nnationals\tO\nat\tO\nDhaka\tT-1\nairport\tT-1\nby\tO\ncustoms\tO\nofficials\tO\n.\tO\n\nFox\tO\nsaid\tT-0\nthe\tO\nBritish\tT-2\ngovernment\tT-1\nwanted\tO\nan\tO\nend\tO\nto\tO\nthe\tO\nalleged\tO\nharassment\tT-3\nof\tO\nits\tO\nnationals\tO\nat\tO\nDhaka\tB-LOC\nairport\tT-4\nby\tO\ncustoms\tO\nofficials\tO\n.\tO\n\nBangladesh\tB-LOC\n's\tO\nCriminal\tO\nInvestigation\tO\nDepartment\tT-1\nhas\tO\ncharged\tT-0\ntwo\tO\nimmigration\tO\nofficials\tO\nin\tO\nconnection\tO\nwith\tO\nMia\tO\n's\tO\nkilling\tO\n.\tO\n\nBangladesh\tO\n's\tO\nCriminal\tB-ORG\nInvestigation\tI-ORG\nDepartment\tI-ORG\nhas\tT-1\ncharged\tT-0\ntwo\tO\nimmigration\tO\nofficials\tO\nin\tO\nconnection\tO\nwith\tO\nMia\tO\n's\tO\nkilling\tO\n.\tO\n\nBangladesh\tO\n's\tO\nCriminal\tO\nInvestigation\tO\nDepartment\tO\nhas\tO\ncharged\tO\ntwo\tO\nimmigration\tT-0\nofficials\tT-0\nin\tO\nconnection\tO\nwith\tO\nMia\tB-PER\n's\tO\nkilling\tT-1\n.\tO\n\nMia\tB-PER\n,\tO\na\tT-0\nfather\tT-1\nof\tO\nfive\tO\nchildren\tO\n,\tO\nhad\tO\na\tO\nrestaurant\tT-2\nbusiness\tT-2\nin\tO\na\tO\nLondon\tT-3\nsuburb\tO\n.\tO\n\nMia\tT-1\n,\tO\na\tO\nfather\tO\nof\tO\nfive\tO\nchildren\tO\n,\tO\nhad\tT-2\na\tO\nrestaurant\tO\nbusiness\tT-0\nin\tO\na\tO\nLondon\tB-LOC\nsuburb\tO\n.\tO\n\nIndia\tB-LOC\nfears\tO\nattempts\tT-1\nto\tO\ndisrupt\tO\nKashmir\tT-0\npolls\tT-2\n.\tO\n\nIndia\tT-0\nfears\tT-1\nattempts\tO\nto\tO\ndisrupt\tT-2\nKashmir\tB-LOC\npolls\tO\n.\tT-2\n\nSRINAGAR\tB-LOC\n,\tO\nIndia\tT-0\n1996-08-22\tO\n\nIndia\tB-LOC\n's\tO\nHome\tO\n(\tO\ninterior\tO\n)\tO\nMinister\tO\naccused\tT-2\nPakistan\tO\non\tO\non\tO\nThursday\tO\nof\tO\nplanning\tO\nto\tO\ndisrupt\tO\nstate\tO\nelections\tO\nin\tO\ntroubled\tO\nJammu\tT-0\nand\tO\nKashmir\tT-1\nstate\tO\n.\tO\n\nIndia\tO\n's\tO\nHome\tO\n(\tO\ninterior\tO\n)\tO\nMinister\tT-1\naccused\tO\nPakistan\tB-LOC\non\tO\non\tO\nThursday\tO\nof\tO\nplanning\tT-0\nto\tT-0\ndisrupt\tT-0\nstate\tO\nelections\tO\nin\tO\ntroubled\tO\nJammu\tT-2\nand\tO\nKashmir\tT-3\nstate\tO\n.\tO\n\nIndia\tT-0\n's\tT-0\nHome\tT-0\n(\tO\ninterior\tO\n)\tO\nMinister\tT-1\naccused\tO\nPakistan\tO\non\tO\non\tO\nThursday\tO\nof\tO\nplanning\tO\nto\tO\ndisrupt\tO\nstate\tO\nelections\tO\nin\tO\ntroubled\tT-2\nJammu\tB-LOC\nand\tT-3\nKashmir\tO\nstate\tO\n.\tO\n\nIndia\tT-0\n's\tO\nHome\tO\n(\tO\ninterior\tO\n)\tO\nMinister\tT-2\naccused\tO\nPakistan\tO\non\tO\non\tO\nThursday\tO\nof\tO\nplanning\tO\nto\tO\ndisrupt\tO\nstate\tO\nelections\tO\nin\tO\ntroubled\tO\nJammu\tT-1\nand\tO\nKashmir\tB-LOC\nstate\tO\n.\tO\n\n\"\tO\nIt\tO\nseems\tO\nthat\tO\nfrom\tO\nacross\tO\nthe\tO\nborder\tO\nthere\tO\nis\tO\ngoing\tO\nto\tO\nbe\tO\na\tO\nplanned\tO\nattempt\tO\nto\tO\ndisrupt\tO\nthe\tO\nelections\tO\n,\tO\n\"\tO\nInderjit\tB-PER\nGupta\tI-PER\ntold\tO\nreporters\tT-0\nin\tO\nthe\tO\nstate\tO\ncapital\tO\nSrinagar\tO\n.\tO\n\n\"\tO\nIt\tO\nseems\tO\nthat\tO\nfrom\tO\nacross\tO\nthe\tO\nborder\tO\nthere\tO\nis\tO\ngoing\tO\nto\tO\nbe\tO\na\tO\nplanned\tO\nattempt\tO\nto\tO\ndisrupt\tO\nthe\tO\nelections\tO\n,\tO\n\"\tO\nInderjit\tT-0\nGupta\tT-0\ntold\tO\nreporters\tO\nin\tO\nthe\tO\nstate\tO\ncapital\tT-1\nSrinagar\tB-LOC\n.\tO\n\nThe\tO\nlocal\tT-2\npolls\tT-2\nnext\tO\nmonth\tO\nwill\tO\nbe\tO\nthe\tO\nfirst\tO\nsince\tO\n1987\tO\nin\tO\nthe\tO\nstate\tO\n,\tO\nclamped\tT-1\nunder\tO\ndirect\tT-0\nrule\tT-0\nfrom\tT-0\nNew\tB-LOC\nDelhi\tI-LOC\nsince\tO\n1990\tO\n.\tO\n\nIndia\tB-LOC\nhas\tT-1\noften\tT-1\naccused\tT-1\nPakistan\tO\nof\tO\nabetting\tO\nmilitancy\tO\nin\tO\nthe\tO\nvalley\tO\n,\tO\na\tO\ncharge\tO\nIslamabad\tT-2\nhas\tO\nalways\tO\ndenied\tO\n.\tO\n\nIndia\tO\nhas\tO\noften\tO\naccused\tT-0\nPakistan\tB-LOC\nof\tO\nabetting\tT-1\nmilitancy\tT-1\nin\tO\nthe\tO\nvalley\tT-2\n,\tO\na\tO\ncharge\tO\nIslamabad\tT-3\nhas\tO\nalways\tO\ndenied\tO\n.\tO\n\nIndia\tT-1\nhas\tO\noften\tO\naccused\tO\nPakistan\tO\nof\tO\nabetting\tO\nmilitancy\tO\nin\tO\nthe\tO\nvalley\tO\n,\tO\na\tO\ncharge\tO\nIslamabad\tB-LOC\nhas\tO\nalways\tO\ndenied\tT-0\n.\tT-1\n\nGupta\tB-PER\nsaid\tT-0\nthere\tO\nmight\tO\nbe\tO\nan\tO\nincrease\tO\nin\tO\nthe\tO\nnumber\tO\nof\tO\npeople\tT-3\ninfiltrating\tT-1\nthe\tO\nKashmir\tO\nvalley\tO\nto\tO\ncreate\tO\ndisturbance\tT-2\nin\tO\nthe\tO\nregion\tO\n.\tO\n\nGupta\tT-0\nsaid\tT-1\nthere\tO\nmight\tO\nbe\tO\nan\tO\nincrease\tT-2\nin\tO\nthe\tO\nnumber\tO\nof\tO\npeople\tO\ninfiltrating\tO\nthe\tT-3\nKashmir\tB-LOC\nvalley\tO\nto\tO\ncreate\tO\ndisturbance\tO\nin\tO\nthe\tO\nregion\tO\n.\tO\n\n\"\tO\nWe\tO\nnoticed\tT-0\namong\tO\nthe\tO\npeople\tO\nwho\tT-2\ncome\tO\nfrom\tO\nacross\tO\nthe\tO\nborder\tO\n,\tO\nthere\tO\nis\tO\na\tO\ngrowing\tO\nnumber\tO\nof\tO\nforeign\tO\nmercenaries\tT-3\n,\tO\n\"\tO\nGupta\tB-PER\nsaid\tT-1\n.\tO\n\nIndia\tB-LOC\nand\tO\nPakistan\tT-1\nhave\tO\nfought\tO\ntwo\tO\nof\tO\ntheir\tO\nthree\tO\nwars\tO\nover\tO\nthe\tO\ntroubled\tO\nregion\tO\nof\tO\nKashmir\tO\nsince\tO\nindependence\tO\nfrom\tO\nBritain\tT-0\nin\tO\n1947\tO\n.\tO\n\nIndia\tO\nand\tO\nPakistan\tB-LOC\nhave\tO\nfought\tO\ntwo\tO\nof\tO\ntheir\tO\nthree\tO\nwars\tO\nover\tO\nthe\tO\ntroubled\tT-0\nregion\tT-0\nof\tO\nKashmir\tO\nsince\tO\nindependence\tO\nfrom\tO\nBritain\tO\nin\tO\n1947\tO\n.\tO\n\nIndia\tO\nand\tO\nPakistan\tO\nhave\tO\nfought\tT-0\ntwo\tO\nof\tO\ntheir\tO\nthree\tO\nwars\tT-1\nover\tO\nthe\tO\ntroubled\tT-3\nregion\tT-3\nof\tT-3\nKashmir\tB-LOC\nsince\tO\nindependence\tT-2\nfrom\tO\nBritain\tO\nin\tO\n1947\tO\n.\tO\n\nIndia\tT-1\nand\tO\nPakistan\tT-2\nhave\tO\nfought\tO\ntwo\tO\nof\tO\ntheir\tO\nthree\tO\nwars\tO\nover\tO\nthe\tO\ntroubled\tO\nregion\tO\nof\tO\nKashmir\tO\nsince\tO\nindependence\tO\nfrom\tT-3\nBritain\tB-LOC\nin\tO\n1947\tO\n.\tO\n\nPrime\tO\nMinister\tO\nH.D.\tB-PER\nDeve\tI-PER\nGowda\tI-PER\n's\tO\ncentre-left\tO\ngovernment\tO\nhopes\tT-0\nthe\tO\nelections\tO\nwill\tO\nhelp\tO\nrestore\tO\nnormality\tO\nand\tO\ndemocratic\tT-1\nrule\tT-1\nin\tO\nJammu\tO\nand\tO\nKashmir\tO\n,\tO\nwhere\tO\nmore\tO\nthan\tO\n20,000\tO\npeople\tO\nhave\tO\ndied\tO\nin\tO\ninsurgency-related\tO\nviolence\tO\nsince\tO\n1990\tO\n.\tO\n\nPrime\tT-0\nMinister\tT-0\nH.D.\tT-0\nDeve\tT-0\nGowda\tT-0\n's\tO\ncentre-left\tO\ngovernment\tO\nhopes\tO\nthe\tO\nelections\tO\nwill\tO\nhelp\tO\nrestore\tO\nnormality\tO\nand\tO\ndemocratic\tT-1\nrule\tO\nin\tO\nJammu\tB-LOC\nand\tO\nKashmir\tO\n,\tO\nwhere\tO\nmore\tO\nthan\tO\n20,000\tO\npeople\tO\nhave\tO\ndied\tO\nin\tO\ninsurgency-related\tT-2\nviolence\tO\nsince\tO\n1990\tO\n.\tT-2\n\nPrime\tO\nMinister\tO\nH.D.\tT-0\nDeve\tT-0\nGowda\tT-0\n's\tT-0\ncentre-left\tO\ngovernment\tO\nhopes\tO\nthe\tO\nelections\tO\nwill\tO\nhelp\tO\nrestore\tO\nnormality\tO\nand\tO\ndemocratic\tO\nrule\tO\nin\tO\nJammu\tT-1\nand\tO\nKashmir\tB-LOC\n,\tO\nwhere\tT-2\nmore\tO\nthan\tO\n20,000\tO\npeople\tO\nhave\tO\ndied\tO\nin\tO\ninsurgency-related\tO\nviolence\tO\nsince\tO\n1990\tO\n.\tO\n\nOver\tO\na\tO\ndozen\tO\nmilitant\tT-1\ngroups\tO\nare\tO\nfighting\tT-2\nNew\tB-LOC\nDelhi\tI-LOC\n's\tO\nrule\tO\nin\tO\nthe\tO\nstate\tT-0\n.\tO\n\nDhaka\tB-LOC\nstocks\tO\nend\tO\nup\tO\non\tO\ngains\tT-0\nby\tO\nengineering\tO\n,\tO\nbanks\tT-1\n.\tO\n\nDhaka\tB-LOC\nstocks\tO\nedged\tO\nup\tO\non\tO\nsharply\tO\nhigher\tO\nvolume\tO\nas\tO\nengineering\tO\nand\tO\ncash\tO\nshares\tO\ngained\tT-0\namid\tO\nbuying\tO\nby\tO\nboth\tO\nsmall\tO\nand\tO\ninstitutional\tO\ninvestors\tO\n,\tO\nbrokers\tO\nsaid\tT-1\n.\tO\n\nThe\tO\nDhaka\tB-ORG\nStock\tI-ORG\nExchange\tI-ORG\n(\tO\nDSE\tT-1\n)\tO\nall-share\tO\nprice\tT-2\nindex\tT-2\nrose\tO\n8.05\tO\npoints\tO\nor\tO\n0.7\tO\npercent\tO\nto\tO\n1,156.79\tO\non\tO\na\tO\nturnover\tT-0\nof\tO\n146.2\tO\nmillion\tO\ntaka\tO\n.\tO\n\nThe\tO\nDhaka\tO\nStock\tT-0\nExchange\tT-0\n(\tO\nDSE\tB-ORG\n)\tO\nall-share\tO\nprice\tO\nindex\tO\nrose\tO\n8.05\tO\npoints\tO\nor\tO\n0.7\tO\npercent\tO\nto\tO\n1,156.79\tO\non\tO\na\tO\nturnover\tT-1\nof\tO\n146.2\tO\nmillion\tO\ntaka\tO\n.\tO\n\nNational\tB-ORG\nBank\tI-ORG\nrose\tO\n12.71\tO\ntaka\tT-1\nto\tO\n228.7\tO\n,\tO\nEastern\tT-2\nCables\tT-2\ngained\tT-3\n20.37\tO\nto\tO\n677.98\tO\nand\tO\nApex\tT-0\nTannery\tT-0\nlost\tT-4\n22.72\tO\nto\tO\n597\tO\n.\tO\n\nNational\tT-0\nBank\tO\nrose\tO\n12.71\tO\ntaka\tO\nto\tO\n228.7\tO\n,\tO\nEastern\tB-ORG\nCables\tI-ORG\ngained\tT-1\n20.37\tT-1\nto\tT-1\n677.98\tT-1\nand\tO\nApex\tO\nTannery\tO\nlost\tO\n22.72\tO\nto\tO\n597\tO\n.\tO\n\nNational\tT-0\nBank\tT-0\nrose\tT-3\n12.71\tO\ntaka\tO\nto\tO\n228.7\tO\n,\tO\nEastern\tT-1\nCables\tT-1\ngained\tT-4\n20.37\tO\nto\tO\n677.98\tO\nand\tO\nApex\tB-ORG\nTannery\tI-ORG\nlost\tT-2\n22.72\tT-2\nto\tT-2\n597\tT-2\n.\tO\n\nIndia\tB-LOC\nRBI\tT-1\nchief\tT-1\nsees\tO\ncut\tT-0\nin\tO\ncash\tO\nreserve\tO\nratio\tO\n.\tO\n\nIndia\tT-1\nRBI\tB-ORG\nchief\tT-0\nsees\tO\ncut\tO\nin\tO\ncash\tO\nreserve\tO\nratio\tO\n.\tO\n\nThe\tT-0\nReserve\tB-ORG\nbank\tI-ORG\nof\tI-ORG\nIndia\tI-ORG\ngovernor\tT-4\nC.\tO\nRangarajan\tO\nsaid\tT-1\non\tO\nThursday\tO\nthat\tO\nhe\tO\nexpected\tO\nthe\tO\ncash\tO\nreserve\tO\nratio\tO\n(\tO\nCRR\tO\n)\tO\nmaintained\tO\nby\tO\nbanks\tT-2\nto\tO\nbe\tO\nreduced\tO\nover\tO\nthe\tO\nmedium\tT-3\nterm\tT-3\n.\tO\n\nThe\tO\nReserve\tT-2\nbank\tT-2\nof\tO\nIndia\tO\ngovernor\tT-0\nC.\tB-PER\nRangarajan\tI-PER\nsaid\tT-1\non\tO\nThursday\tO\nthat\tO\nhe\tO\nexpected\tO\nthe\tO\ncash\tO\nreserve\tO\nratio\tO\n(\tO\nCRR\tO\n)\tO\nmaintained\tO\nby\tO\nbanks\tO\nto\tO\nbe\tO\nreduced\tO\nover\tO\nthe\tO\nmedium\tO\nterm\tO\n.\tO\n\n\"\tO\nOver\tO\nthe\tO\nmedium\tO\nterm\tO\n,\tO\nyes\tO\n,\tO\n\"\tO\nhe\tO\ntold\tT-1\nReuters\tB-ORG\nafter\tO\naddressing\tT-0\nindustrialists\tO\nin\tO\nthe\tO\ncapital\tT-2\n.\tO\n\nRangarajan\tB-PER\nexplained\tT-0\nthat\tO\nthe\tO\ncash\tO\nreserve\tO\nratio\tO\nwas\tO\nan\tO\ninstrument\tO\nthat\tO\ncentral\tO\nbanks\tO\ncould\tO\nuse\tO\nto\tO\nregulate\tO\nmoney\tO\nsupply\tO\nby\tO\nreducing\tO\nor\tO\nincreasing\tO\nthe\tO\nratio\tO\n.\tO\n\n--\tO\nNew\tB-LOC\nDelhi\tI-LOC\nnewsroom\tT-1\n,\tO\n+91-11-3012024\tT-0\n\nTwo\tO\npct\tO\nIndia\tB-LOC\ncurrent\tO\naccount\tO\ndeficit\tT-0\nviable\tO\n-\tO\nRBI\tO\n.\tO\n\nTwo\tO\npct\tO\nIndia\tO\ncurrent\tO\naccount\tO\ndeficit\tT-0\nviable\tO\n-\tO\nRBI\tB-ORG\n.\tO\n\nThe\tO\nReserve\tB-ORG\nBank\tI-ORG\nof\tI-ORG\nIndia\tI-ORG\nGovernor\tO\nChakravarty\tO\nRangarajan\tO\nsaid\tT-0\non\tO\nThursday\tO\nthat\tO\na\tO\ncurrent\tO\naccount\tT-3\ndeficit\tO\nof\tO\ntwo\tO\npercent\tO\nof\tO\ngross\tO\ndomestic\tO\nproduct\tO\n(\tO\nGDP\tO\n)\tO\nwas\tO\nsustainable\tT-1\ngiven\tO\nthe\tO\ncurrrent\tO\nrate\tO\nof\tO\ngrowth\tT-2\n.\tO\n\nThe\tT-0\nReserve\tT-0\nBank\tT-0\nof\tT-0\nIndia\tT-0\nGovernor\tT-1\nChakravarty\tB-PER\nRangarajan\tI-PER\nsaid\tT-2\non\tO\nThursday\tO\nthat\tO\na\tO\ncurrent\tO\naccount\tO\ndeficit\tO\nof\tO\ntwo\tO\npercent\tO\nof\tO\ngross\tO\ndomestic\tO\nproduct\tO\n(\tO\nGDP\tO\n)\tO\nwas\tO\nsustainable\tO\ngiven\tO\nthe\tO\ncurrrent\tO\nrate\tO\nof\tO\ngrowth\tO\n.\tO\n\n\"\tO\nThe\tT-1\ncurrent\tT-1\naccount\tT-1\ndeficit\tO\nof\tO\naround\tO\ntwo\tO\npercent\tO\nof\tO\nGDP\tT-0\nis\tO\na\tO\nsustainable\tO\nlevel\tO\nof\tO\ndeficit\tO\ngiven\tO\nthe\tO\nexpected\tO\nreal\tO\ngrowth\tT-2\nrate\tT-2\nand\tO\nthe\tO\ntrends\tO\nin\tO\nimports\tO\nand\tO\nexports\tO\n,\tO\n\"\tO\nRangarajan\tB-PER\nsaid\tT-4\nin\tO\nan\tO\naddress\tO\nto\tO\nbusiness\tT-3\nleaders\tT-3\nin\tO\nNew\tO\nDelhi\tO\n.\tO\n\n\"\tO\nThe\tO\ncurrent\tO\naccount\tO\ndeficit\tO\nof\tO\naround\tO\ntwo\tO\npercent\tO\nof\tO\nGDP\tO\nis\tO\na\tO\nsustainable\tT-1\nlevel\tO\nof\tO\ndeficit\tO\ngiven\tO\nthe\tO\nexpected\tO\nreal\tO\ngrowth\tO\nrate\tO\nand\tO\nthe\tO\ntrends\tO\nin\tO\nimports\tO\nand\tO\nexports\tO\n,\tO\n\"\tO\nRangarajan\tO\nsaid\tO\nin\tO\nan\tO\naddress\tO\nto\tO\nbusiness\tO\nleaders\tT-0\nin\tO\nNew\tB-LOC\nDelhi\tI-LOC\n.\tO\n\nRangarajan\tB-PER\nsaid\tT-0\na\tO\ncurrent\tO\naccount\tT-1\ndeficit\tO\nof\tO\ntwo\tO\npercent\tO\nbrought\tO\nabout\tO\nby\tO\na\tO\n16-17\tO\npercent\tO\nannual\tO\ngrowth\tO\nin\tO\nexports\tO\nand\tO\na\tO\n14-15\tO\npercent\tO\nrise\tO\nin\tO\nimports\tO\nalong\tO\nwith\tO\nan\tO\nincrease\tO\nin\tO\nnon-debt\tO\nflows\tO\ncould\tO\nlead\tO\nto\tO\na\tO\nreduction\tO\nin\tO\nthe\tO\ndebt-service\tO\nratio\tO\nto\tO\nbelow\tO\n20\tO\npercent\tO\nover\tO\nthe\tO\nnext\tO\nfive\tO\nyears\tO\n.\tO\n\n--\tO\nBombay\tB-LOC\nnewsroom\tT-0\n+91-22-265\tO\n9000\tO\n\nMother\tB-PER\nTeresa\tI-PER\ndevoted\tT-1\nto\tO\nworld\tO\n's\tO\npoor\tT-0\n.\tO\n\nMother\tB-PER\nTeresa\tI-PER\n,\tO\nknown\tT-1\nas\tT-1\nthe\tT-1\nSaint\tT-1\nof\tT-1\nthe\tT-1\nGutters\tT-1\n,\tO\nwon\tT-2\nthe\tO\nNobel\tO\nPeace\tO\nPrize\tO\nin\tO\n1979\tO\nfor\tO\nbringing\tO\nhope\tO\nand\tO\ndignity\tO\nto\tO\nmillions\tO\nof\tO\npoor\tO\n,\tO\nunwanted\tO\npeople\tO\nwith\tO\nher\tO\nsimple\tO\nmessage\tO\n:\tO\n\"\tO\nThe\tO\npoor\tO\nmust\tO\nknow\tO\nthat\tO\nwe\tO\nlove\tO\nthem\tO\n.\tO\n\"\tO\n\nMother\tO\nTeresa\tO\n,\tO\nknown\tO\nas\tO\nthe\tO\nSaint\tB-PER\nof\tI-PER\nthe\tI-PER\nGutters\tI-PER\n,\tO\nwon\tO\nthe\tO\nNobel\tO\nPeace\tO\nPrize\tO\nin\tO\n1979\tO\nfor\tO\nbringing\tT-0\nhope\tT-0\nand\tT-0\ndignity\tT-0\nto\tO\nmillions\tO\nof\tO\npoor\tO\n,\tO\nunwanted\tO\npeople\tO\nwith\tO\nher\tO\nsimple\tO\nmessage\tO\n:\tO\n\"\tO\nThe\tO\npoor\tO\nmust\tO\nknow\tO\nthat\tO\nwe\tO\nlove\tO\nthem\tO\n.\tO\n\"\tO\n\nMother\tO\nTeresa\tO\n,\tO\nknown\tT-1\nas\tO\nthe\tO\nSaint\tO\nof\tO\nthe\tO\nGutters\tO\n,\tO\nwon\tT-2\nthe\tO\nNobel\tB-MISC\nPeace\tI-MISC\nPrize\tI-MISC\nin\tO\n1979\tO\nfor\tO\nbringing\tO\nhope\tO\nand\tO\ndignity\tO\nto\tO\nmillions\tO\nof\tO\npoor\tT-3\n,\tO\nunwanted\tT-0\npeople\tO\nwith\tO\nher\tO\nsimple\tO\nmessage\tO\n:\tO\n\"\tO\nThe\tO\npoor\tT-4\nmust\tO\nknow\tO\nthat\tO\nwe\tO\nlove\tO\nthem\tO\n.\tO\n\"\tO\n\nWhile\tO\nthe\tO\nworld\tO\nheaps\tO\nhonours\tO\non\tO\nher\tO\nand\tO\neven\tO\nregards\tO\nher\tO\nas\tO\na\tO\nliving\tT-0\nsaint\tT-0\n,\tO\nthe\tO\nnun\tO\nof\tO\nAlbanian\tB-MISC\ndescent\tO\nmaintains\tT-1\nshe\tO\nis\tO\nmerely\tO\ndoing\tO\nGod\tO\n's\tO\nwork\tO\n.\tO\n\nWhile\tO\nthe\tO\nworld\tO\nheaps\tO\nhonours\tO\non\tO\nher\tO\nand\tO\neven\tO\nregards\tO\nher\tO\nas\tO\na\tO\nliving\tO\nsaint\tO\n,\tO\nthe\tO\nnun\tO\nof\tO\nAlbanian\tO\ndescent\tO\nmaintains\tO\nshe\tT-0\nis\tT-0\nmerely\tO\ndoing\tO\nGod\tB-PER\n's\tO\nwork\tT-1\n.\tO\n\nThe\tO\ndiminutive\tO\nRoman\tB-MISC\nCatholic\tI-MISC\nmissionary\tT-0\nwas\tO\non\tO\nrespiratory\tO\nsupport\tT-1\nin\tO\nintensive\tO\ncare\tO\nin\tO\nan\tO\nIndian\tO\nnursing\tO\nhome\tO\non\tO\nThursday\tO\nafter\tO\nsuffering\tO\nheart\tO\nfailure\tO\n.\tO\n\nThe\tO\ndiminutive\tO\nRoman\tT-0\nCatholic\tT-0\nmissionary\tT-0\nwas\tO\non\tO\nrespiratory\tT-1\nsupport\tT-1\nin\tO\nintensive\tT-2\ncare\tT-2\nin\tO\nan\tO\nIndian\tB-MISC\nnursing\tO\nhome\tO\non\tO\nThursday\tO\nafter\tO\nsuffering\tO\nheart\tT-3\nfailure\tT-3\n.\tO\n\nBut\tO\nan\tO\nattending\tT-2\ndoctor\tO\nsaid\tT-1\nMother\tB-PER\nTeresa\tI-PER\n,\tO\nwho\tO\nturns\tO\n86\tT-0\nnext\tT-3\nTuesday\tT-3\n,\tO\nwas\tO\nconscious\tO\nand\tO\nin\tO\nstable\tO\ncondition\tO\n.\tO\n\nThe\tO\ntask\tO\nMother\tB-PER\nTeresa\tI-PER\nbegan\tT-0\nalone\tO\nin\tO\n1949\tO\nin\tO\nthe\tO\nslums\tO\nof\tO\ndensely-populated\tO\nCalcutta\tO\n,\tO\nand\tO\ngrew\tO\nto\tO\ntouch\tO\nthe\tO\nhearts\tO\nof\tO\npeople\tO\naround\tO\nthe\tO\nworld\tO\n.\tO\n\nThe\tO\ntask\tO\nMother\tO\nTeresa\tO\nbegan\tO\nalone\tO\nin\tO\n1949\tO\nin\tO\nthe\tO\nslums\tO\nof\tO\ndensely-populated\tT-1\nCalcutta\tB-LOC\n,\tO\nand\tO\ngrew\tO\nto\tO\ntouch\tO\nthe\tO\nhearts\tO\nof\tO\npeople\tO\naround\tO\nthe\tO\nworld\tO\n.\tT-1\n\nWhen\tO\nin\tO\n1979\tO\nshe\tO\nwas\tO\ntold\tO\nshe\tO\nhad\tO\nwon\tT-0\nthe\tT-0\nNobel\tB-MISC\nPeace\tI-MISC\nPrize\tI-MISC\n,\tO\nshe\tO\nsaid\tT-1\ncharacteristically\tO\n:\tO\n\"\tO\nI\tO\nam\tO\nunworthy\tO\n.\tO\n\"\tO\n\nThe\tO\nworld\tO\ndisagreed\tO\n,\tO\nshowering\tO\nmore\tO\nthan\tO\n80\tO\nnational\tO\nand\tO\ninternational\tO\nhonours\tT-1\non\tO\nher\tO\nincluding\tO\nthe\tO\nBharat\tB-MISC\nRatna\tI-MISC\n,\tO\nor\tT-2\nJewel\tT-0\nof\tT-0\nIndia\tT-0\n,\tO\nthe\tO\ncountry\tO\n's\tO\nhighest\tO\ncivilian\tO\naward\tO\n.\tO\n\nThe\tO\nworld\tO\ndisagreed\tO\n,\tO\nshowering\tO\nmore\tO\nthan\tO\n80\tO\nnational\tO\nand\tO\ninternational\tT-3\nhonours\tO\non\tO\nher\tO\nincluding\tO\nthe\tO\nBharat\tT-2\nRatna\tT-2\n,\tO\nor\tT-0\nJewel\tB-MISC\nof\tI-MISC\nIndia\tI-MISC\n,\tO\nthe\tO\ncountry\tO\n's\tO\nhighest\tO\ncivilian\tO\naward\tT-1\n.\tT-3\n\nA\tO\nyear\tO\nlater\tO\n,\tO\nthe\tO\nVatican\tB-LOC\nannounced\tT-2\nshe\tO\nwas\tO\nstepping\tT-3\ndown\tO\nas\tO\nSuperior\tO\nof\tO\nher\tO\nMissionaries\tT-0\nof\tO\nCharity\tT-1\norder\tT-1\n.\tO\n\nA\tO\nyear\tO\nlater\tO\n,\tO\nthe\tO\nVatican\tT-1\nannounced\tT-0\nshe\tO\nwas\tO\nstepping\tO\ndown\tO\nas\tO\nSuperior\tO\nof\tO\nher\tO\nMissionaries\tB-ORG\nof\tI-ORG\nCharity\tI-ORG\norder\tO\n.\tO\n\nIn\tO\n1991\tO\n,\tO\nMother\tB-PER\nTeresa\tI-PER\nwas\tT-1\ntreated\tT-1\nat\tO\na\tO\nCalifornia\tO\nhospital\tO\nfor\tO\nheart\tO\ndisease\tT-0\nand\tO\nbacterial\tO\npneumonia\tO\n.\tO\n\nIn\tO\n1991\tO\n,\tO\nMother\tT-0\nTeresa\tT-0\nwas\tO\ntreated\tT-1\nat\tO\na\tO\nCalifornia\tB-LOC\nhospital\tT-2\nfor\tO\nheart\tO\ndisease\tO\nand\tO\nbacterial\tO\npneumonia\tO\n.\tO\n\nIn\tO\n1993\tT-2\n,\tO\nshe\tO\nfell\tT-0\nin\tO\nRome\tB-LOC\nand\tO\nbroke\tT-1\nthree\tT-1\nribs\tT-1\n.\tO\n\nIn\tO\nAugust\tO\nthe\tO\nsame\tO\nyear\tO\n,\tO\nwhile\tT-1\nin\tT-1\nNew\tB-LOC\nDelhi\tI-LOC\nto\tO\nreceive\tT-0\nyet\tO\nanother\tO\naward\tO\n,\tO\nshe\tO\ndeveloped\tO\nmalaria\tO\n,\tO\ncomplicated\tO\nby\tO\nher\tO\nheart\tO\nand\tO\nlung\tO\nproblems\tO\n.\tO\n\nMother\tB-PER\nTeresa\tI-PER\nwas\tO\nborn\tT-0\nAgnes\tO\nGoinxha\tO\nBejaxhiu\tO\nto\tO\nAlbanian\tO\nparents\tO\nin\tO\nSkopje\tO\n,\tO\nin\tO\nwhat\tO\nwas\tO\nthen\tO\nSerbia\tO\n,\tO\non\tO\nAugust\tO\n27\tO\n,\tO\n1910\tO\n.\tO\n\nMother\tT-1\nTeresa\tT-1\nwas\tO\nborn\tT-0\nAgnes\tB-PER\nGoinxha\tI-PER\nBejaxhiu\tI-PER\nto\tO\nAlbanian\tT-2\nparents\tT-2\nin\tO\nSkopje\tO\n,\tO\nin\tO\nwhat\tO\nwas\tO\nthen\tO\nSerbia\tO\n,\tO\non\tO\nAugust\tO\n27\tO\n,\tO\n1910\tO\n.\tO\n\nMother\tO\nTeresa\tO\nwas\tO\nborn\tO\nAgnes\tO\nGoinxha\tT-2\nBejaxhiu\tT-2\nto\tT-0\nAlbanian\tB-MISC\nparents\tT-1\nin\tO\nSkopje\tO\n,\tO\nin\tO\nwhat\tO\nwas\tO\nthen\tO\nSerbia\tO\n,\tO\non\tO\nAugust\tO\n27\tO\n,\tO\n1910\tO\n.\tO\n\nMother\tO\nTeresa\tO\nwas\tO\nborn\tO\nAgnes\tO\nGoinxha\tO\nBejaxhiu\tO\nto\tO\nAlbanian\tO\nparents\tO\nin\tO\nSkopje\tB-LOC\n,\tO\nin\tO\nwhat\tO\nwas\tO\nthen\tO\nSerbia\tT-0\n,\tO\non\tO\nAugust\tO\n27\tO\n,\tO\n1910\tO\n.\tO\n\nMother\tO\nTeresa\tO\nwas\tO\nborn\tO\nAgnes\tO\nGoinxha\tO\nBejaxhiu\tO\nto\tO\nAlbanian\tO\nparents\tO\nin\tO\nSkopje\tO\n,\tO\nin\tT-0\nwhat\tO\nwas\tO\nthen\tO\nSerbia\tB-LOC\n,\tO\non\tO\nAugust\tO\n27\tO\n,\tO\n1910\tO\n.\tO\n\nAt\tO\nthe\tO\nage\tO\nof\tO\n18\tO\nshe\tO\nbecame\tT-1\na\tO\nLoretto\tB-MISC\nnun\tO\n,\tO\nhoping\tO\nto\tO\nwork\tO\nat\tO\nthe\tO\nOrder\tO\n's\tO\nCalcutta\tO\nmission\tT-0\n.\tO\n\nAt\tO\nthe\tO\nage\tO\nof\tO\n18\tO\nshe\tO\nbecame\tO\na\tO\nLoretto\tT-1\nnun\tO\n,\tO\nhoping\tO\nto\tO\nwork\tO\nat\tO\nthe\tO\nOrder\tT-0\n's\tT-0\nCalcutta\tB-LOC\nmission\tO\n.\tO\n\nShe\tO\nwas\tO\nsent\tT-3\nto\tT-0\nLoretto\tB-LOC\nAbbey\tI-LOC\nin\tT-1\nDublin\tT-2\nand\tO\nfrom\tO\nthere\tO\nto\tO\nIndia\tO\nto\tO\nbegin\tO\nher\tO\nnovitiate\tO\nand\tO\nteach\tO\ngeography\tO\nat\tO\na\tO\nconvent\tO\nschool\tO\nin\tO\nCalcutta\tO\n.\tO\n\nShe\tO\nwas\tO\nsent\tT-2\nto\tO\nLoretto\tO\nAbbey\tO\nin\tO\nDublin\tB-LOC\nand\tO\nfrom\tO\nthere\tO\nto\tO\nIndia\tO\nto\tO\nbegin\tT-3\nher\tO\nnovitiate\tO\nand\tO\nteach\tO\ngeography\tT-0\nat\tO\na\tO\nconvent\tT-1\nschool\tO\nin\tO\nCalcutta\tO\n.\tO\n\nShe\tO\nwas\tO\nsent\tO\nto\tO\nLoretto\tT-1\nAbbey\tT-1\nin\tO\nDublin\tO\nand\tO\nfrom\tT-0\nthere\tT-0\nto\tT-0\nIndia\tB-LOC\nto\tO\nbegin\tT-2\nher\tT-2\nnovitiate\tT-2\nand\tO\nteach\tT-3\ngeography\tT-3\nat\tO\na\tO\nconvent\tT-4\nschool\tO\nin\tO\nCalcutta\tT-5\n.\tO\n\nShe\tO\nwas\tO\nsent\tO\nto\tO\nLoretto\tT-3\nAbbey\tO\nin\tO\nDublin\tT-0\nand\tO\nfrom\tO\nthere\tO\nto\tO\nIndia\tO\nto\tO\nbegin\tO\nher\tO\nnovitiate\tO\nand\tO\nteach\tO\ngeography\tO\nat\tO\na\tO\nconvent\tT-1\nschool\tO\nin\tT-2\nCalcutta\tB-LOC\n.\tT-1\n\nThe\tO\nVatican\tB-LOC\nand\tO\nthe\tO\nmother\tO\nsuperior\tO\nin\tO\nDublin\tT-0\napproved\tO\nand\tO\nafter\tO\nintensive\tO\ntraining\tT-2\nas\tO\na\tO\nnurse\tO\nwith\tO\nAmerican\tO\nmissionaries\tO\nshe\tO\nopened\tO\nher\tO\nfirst\tO\nCalcutta\tT-1\nslum\tT-1\nschool\tO\nin\tO\nDecember\tO\n1949\tO\n.\tO\n\nThe\tO\nVatican\tO\nand\tO\nthe\tO\nmother\tT-2\nsuperior\tT-0\nin\tT-1\nDublin\tB-LOC\napproved\tT-3\nand\tO\nafter\tO\nintensive\tO\ntraining\tO\nas\tO\na\tO\nnurse\tO\nwith\tO\nAmerican\tO\nmissionaries\tO\nshe\tO\nopened\tO\nher\tO\nfirst\tO\nCalcutta\tO\nslum\tO\nschool\tO\nin\tO\nDecember\tO\n1949\tO\n.\tO\n\nThe\tO\nVatican\tO\nand\tO\nthe\tO\nmother\tO\nsuperior\tO\nin\tO\nDublin\tO\napproved\tO\nand\tO\nafter\tO\nintensive\tO\ntraining\tO\nas\tO\na\tO\nnurse\tO\nwith\tO\nAmerican\tB-MISC\nmissionaries\tT-0\nshe\tO\nopened\tO\nher\tO\nfirst\tO\nCalcutta\tO\nslum\tO\nschool\tO\nin\tO\nDecember\tO\n1949\tO\n.\tO\n\nThe\tO\nVatican\tO\nand\tO\nthe\tO\nmother\tO\nsuperior\tO\nin\tO\nDublin\tO\napproved\tO\nand\tO\nafter\tO\nintensive\tO\ntraining\tO\nas\tO\na\tO\nnurse\tO\nwith\tO\nAmerican\tO\nmissionaries\tT-2\nshe\tO\nopened\tT-1\nher\tT-1\nfirst\tT-1\nCalcutta\tB-LOC\nslum\tT-0\nschool\tT-3\nin\tO\nDecember\tO\n1949\tO\n.\tO\n\nShe\tO\ntook\tO\nthe\tO\nname\tT-0\nof\tO\nTeresa\tB-PER\n,\tO\nafter\tO\nFrance\tO\n's\tO\nSaint\tT-1\nTherese\tT-1\nof\tO\nthe\tO\nChild\tT-2\nJesus\tT-2\n.\tO\n\nShe\tO\ntook\tO\nthe\tO\nname\tT-0\nof\tO\nTeresa\tO\n,\tO\nafter\tO\nFrance\tB-LOC\n's\tO\nSaint\tT-1\nTherese\tT-1\nof\tO\nthe\tO\nChild\tO\nJesus\tO\n.\tO\n\nShe\tO\ntook\tO\nthe\tO\nname\tT-0\nof\tT-0\nTeresa\tO\n,\tO\nafter\tO\nFrance\tO\n's\tO\nSaint\tT-2\nTherese\tB-PER\nof\tO\nthe\tT-1\nChild\tT-1\nJesus\tO\n.\tO\n\nShe\tO\ntook\tT-3\nthe\tO\nname\tO\nof\tO\nTeresa\tT-0\n,\tO\nafter\tO\nFrance\tO\n's\tO\nSaint\tO\nTherese\tT-1\nof\tO\nthe\tO\nChild\tT-2\nJesus\tB-PER\n.\tO\n\nIn\tT-1\nIndia\tB-LOC\nshe\tO\nwas\tO\nsimply\tO\ncalled\tT-0\nMother\tO\n.\tO\n\nIn\tO\nIndia\tO\nshe\tT-0\nwas\tO\nsimply\tO\ncalled\tO\nMother\tB-PER\n.\tO\n\nMother\tB-PER\nTeresa\tI-PER\nset\tT-0\nup\tT-0\nher\tT-1\nfirst\tO\nhome\tO\nfor\tO\nthe\tO\ndying\tO\nin\tO\na\tO\nHindu\tO\nrest\tO\nhouse\tO\nin\tO\nCalcutta\tO\nafter\tO\nshe\tO\nsaw\tT-2\na\tO\npenniless\tO\nwoman\tO\nturned\tO\naway\tO\nby\tO\na\tO\ncity\tO\nhospital\tO\n.\tO\n\nMother\tT-0\nTeresa\tT-0\nset\tT-4\nup\tT-4\nher\tO\nfirst\tO\nhome\tT-1\nfor\tO\nthe\tO\ndying\tO\nin\tO\na\tO\nHindu\tB-MISC\nrest\tO\nhouse\tT-2\nin\tO\nCalcutta\tT-3\nafter\tO\nshe\tO\nsaw\tT-5\na\tO\npenniless\tO\nwoman\tO\nturned\tO\naway\tO\nby\tO\na\tO\ncity\tO\nhospital\tO\n.\tO\n\nMother\tO\nTeresa\tO\nset\tO\nup\tO\nher\tO\nfirst\tO\nhome\tT-3\nfor\tO\nthe\tO\ndying\tT-1\nin\tO\na\tO\nHindu\tO\nrest\tO\nhouse\tO\nin\tO\nCalcutta\tB-LOC\nafter\tO\nshe\tO\nsaw\tT-2\na\tO\npenniless\tT-0\nwoman\tO\nturned\tT-4\naway\tO\nby\tO\na\tO\ncity\tO\nhospital\tO\n.\tO\n\nNamed\tT-0\n\"\tO\nNirmal\tB-LOC\nHriday\tI-LOC\n\"\tO\n(\tO\nTender\tO\nHeart\tO\n)\tO\n,\tO\nit\tO\nwas\tO\nthe\tO\nfirst\tO\nof\tO\na\tO\nchain\tT-2\nof\tO\n150\tO\nhomes\tO\nfor\tO\ndying\tT-1\n,\tO\ndestitute\tO\npeople\tO\n,\tO\nadmitting\tO\nnearly\tO\n18,000\tO\na\tO\nyear\tO\n.\tO\n\nNamed\tO\n\"\tO\nNirmal\tT-0\nHriday\tT-0\n\"\tO\n(\tO\nTender\tB-LOC\nHeart\tI-LOC\n)\tO\n,\tO\nit\tO\nwas\tT-1\nthe\tO\nfirst\tO\nof\tO\na\tO\nchain\tO\nof\tO\n150\tO\nhomes\tO\nfor\tO\ndying\tO\n,\tO\ndestitute\tO\npeople\tO\n,\tO\nadmitting\tO\nnearly\tO\n18,000\tO\na\tO\nyear\tO\n.\tO\n\nHer\tO\nMissionaries\tB-ORG\nof\tI-ORG\nCharity\tI-ORG\n,\tO\na\tO\nRoman\tT-0\nCatholic\tO\nreligious\tT-1\norder\tO\nshe\tO\nfounded\tT-2\nin\tO\n1949\tO\n,\tO\nnow\tO\nruns\tO\nabout\tO\n300\tO\nhomes\tO\nfor\tO\nunwanted\tO\nchildren\tO\nand\tO\nthe\tO\ndestitute\tO\nin\tO\nIndia\tO\nand\tO\nabroad\tO\n.\tO\n\nHer\tO\nMissionaries\tO\nof\tO\nCharity\tO\n,\tO\na\tO\nRoman\tB-MISC\nCatholic\tI-MISC\nreligious\tT-1\norder\tO\nshe\tO\nfounded\tO\nin\tO\n1949\tO\n,\tO\nnow\tO\nruns\tT-0\nabout\tO\n300\tO\nhomes\tO\nfor\tO\nunwanted\tO\nchildren\tO\nand\tO\nthe\tO\ndestitute\tO\nin\tO\nIndia\tO\nand\tO\nabroad\tO\n.\tO\n\nHer\tO\nMissionaries\tO\nof\tO\nCharity\tO\n,\tO\na\tO\nRoman\tO\nCatholic\tO\nreligious\tO\norder\tO\nshe\tO\nfounded\tO\nin\tO\n1949\tO\n,\tO\nnow\tO\nruns\tO\nabout\tO\n300\tO\nhomes\tO\nfor\tO\nunwanted\tO\nchildren\tO\nand\tO\nthe\tO\ndestitute\tO\nin\tT-0\nIndia\tB-LOC\nand\tO\nabroad\tO\n.\tO\n\nIn\tO\n1994\tO\na\tO\nBritish\tB-MISC\ntelevision\tT-0\ndocumentary\tT-0\ncalled\tO\nthe\tO\nmyth\tO\naround\tO\nMother\tT-1\nTeresa\tT-1\na\tO\nmixture\tO\nof\tO\n\"\tO\nhyperbole\tO\nand\tO\ncredulity\tO\n\"\tO\n.\tO\n\nIn\tO\n1994\tO\na\tO\nBritish\tT-1\ntelevision\tT-1\ndocumentary\tO\ncalled\tO\nthe\tO\nmyth\tO\naround\tT-0\nMother\tB-PER\nTeresa\tI-PER\na\tO\nmixture\tO\nof\tO\n\"\tO\nhyperbole\tT-2\nand\tT-2\ncredulity\tT-2\n\"\tO\n.\tO\n\nCatholics\tB-MISC\naround\tT-0\nthe\tT-0\nworld\tT-0\nrose\tO\nto\tO\nher\tT-2\ndefence\tT-1\n.\tO\n\nRTRS\tB-ORG\n-\tO\nFOCUS-News\tT-1\nforecasts\tO\nalien-led\tO\nprofit\tT-0\nboost\tT-0\n.\tO\n\nMedia\tO\nbaron\tT-2\nRupert\tB-PER\nMurdoch\tI-PER\n's\tO\nNews\tT-3\nCorp\tT-3\nLtd\tT-3\nreported\tT-1\nlower\tO\nthan\tO\nexpected\tO\n1995/96\tT-4\nprofits\tT-4\non\tO\nThursday\tO\n,\tO\nbut\tO\nforecast\tO\nthat\tO\nthe\tO\nhit\tO\nfilm\tO\n\"\tO\nIndependence\tT-0\nDay\tT-0\n\"\tO\nwould\tO\nhelp\tO\nincrease\tO\nprofits\tO\nby\tO\nat\tO\nleast\tO\n20\tO\npercent\tO\nin\tO\n1996/97\tO\n.\tO\n\nMedia\tT-1\nbaron\tT-1\nRupert\tT-0\nMurdoch\tT-0\n's\tT-0\nNews\tB-ORG\nCorp\tI-ORG\nLtd\tI-ORG\nreported\tO\nlower\tO\nthan\tO\nexpected\tO\n1995/96\tO\nprofits\tO\non\tO\nThursday\tO\n,\tO\nbut\tO\nforecast\tO\nthat\tO\nthe\tO\nhit\tO\nfilm\tO\n\"\tO\nIndependence\tO\nDay\tO\n\"\tO\nwould\tO\nhelp\tO\nincrease\tO\nprofits\tO\nby\tO\nat\tO\nleast\tO\n20\tO\npercent\tO\nin\tO\n1996/97\tO\n.\tO\n\nMedia\tO\nbaron\tO\nRupert\tO\nMurdoch\tO\n's\tO\nNews\tO\nCorp\tO\nLtd\tO\nreported\tO\nlower\tO\nthan\tO\nexpected\tO\n1995/96\tO\nprofits\tO\non\tO\nThursday\tO\n,\tO\nbut\tO\nforecast\tO\nthat\tO\nthe\tO\nhit\tO\nfilm\tO\n\"\tO\nIndependence\tB-MISC\nDay\tI-MISC\n\"\tO\nwould\tO\nhelp\tT-0\nincrease\tO\nprofits\tO\nby\tO\nat\tO\nleast\tO\n20\tO\npercent\tO\nin\tO\n1996/97\tO\n.\tO\n\n\"\tO\nFrom\tO\nan\tO\nearnings\tO\nperspective\tO\n,\tO\nthe\tO\ncurrent\tO\nfiscal\tO\nyear\tO\nhas\tO\nbegun\tO\nwith\tO\ngreat\tO\npromise\tO\ndue\tO\nto\tO\nthe\tO\nhit\tT-0\nmotion\tT-0\npicture\tT-0\n'\tO\nIndependence\tB-MISC\nDay\tI-MISC\n,\tO\n'\tO\n\"\tO\nNews\tO\nCorp\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\nannouncing\tO\nits\tO\nresults\tO\nfor\tO\nthe\tO\nyear\tO\nto\tO\nJune\tO\n30\tO\n,\tO\n1996\tO\n.\tO\n\n\"\tO\nFrom\tO\nan\tO\nearnings\tO\nperspective\tO\n,\tO\nthe\tO\ncurrent\tO\nfiscal\tO\nyear\tO\nhas\tO\nbegun\tO\nwith\tO\ngreat\tO\npromise\tO\ndue\tO\nto\tO\nthe\tO\nhit\tO\nmotion\tO\npicture\tO\n'\tO\nIndependence\tO\nDay\tO\n,\tO\n'\tO\n\"\tO\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tT-0\nin\tO\na\tO\nstatement\tT-1\nannouncing\tT-3\nits\tT-3\nresults\tT-3\nfor\tO\nthe\tT-2\nyear\tT-2\nto\tT-2\nJune\tT-2\n30\tT-2\n,\tT-2\n1996\tT-2\n.\tO\n\nIt\tO\nsaid\tO\nmoderating\tO\npaper\tO\nprices\tO\nand\tO\nsolid\tO\norders\tO\nfor\tO\nadvertising\tO\nat\tO\nits\tO\nFox\tB-ORG\nBroadcasting\tI-ORG\ntelevision\tT-0\nnetwork\tT-1\nin\tO\nthe\tO\nUnited\tO\nStates\tO\nwould\tO\nalso\tO\nhelp\tO\nboost\tO\nprofits\tO\nin\tO\nthe\tO\n1996/97\tO\nyear\tO\n.\tO\n\"\tO\n\nIt\tO\nsaid\tO\nmoderating\tT-1\npaper\tO\nprices\tO\nand\tO\nsolid\tO\norders\tO\nfor\tO\nadvertising\tO\nat\tO\nits\tO\nFox\tO\nBroadcasting\tT-2\ntelevision\tO\nnetwork\tT-0\nin\tO\nthe\tO\nUnited\tB-LOC\nStates\tI-LOC\nwould\tO\nalso\tO\nhelp\tO\nboost\tO\nprofits\tO\nin\tO\nthe\tO\n1996/97\tO\nyear\tO\n.\tO\n\"\tO\n\nA\tO\nbudgeted\tO\nprofit\tO\nincrease\tO\nof\tO\nat\tO\nleast\tO\n20\tO\npercent\tO\nfor\tO\nthe\tO\nfull\tO\nyear\tO\ncurrently\tO\nappears\tO\nvery\tO\nattainable\tT-0\n,\tO\n\"\tO\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tO\n.\tO\n\nNews\tB-ORG\nannounced\tO\npre-abnormals\tT-0\nnet\tO\nprofit\tO\nfor\tO\nthe\tO\nyear\tO\nfell\tO\nsix\tO\npercent\tO\nto\tO\nA$\tO\n1.26\tO\nbillion\tO\n(\tO\nUS$\tO\n995\tO\nmillion\tO\n)\tO\nand\tO\nearnings\tO\nper\tO\nshare\tO\ndropped\tT-1\nto\tO\n40\tO\ncents\tO\nfrom\tO\n46\tO\ncents\tO\n.\tT-0\n\nNews\tO\nannounced\tT-0\npre-abnormals\tO\nnet\tO\nprofit\tO\nfor\tO\nthe\tO\nyear\tO\nfell\tO\nsix\tT-3\npercent\tT-3\nto\tT-3\nA$\tB-MISC\n1.26\tO\nbillion\tO\n(\tO\nUS$\tO\n995\tO\nmillion\tO\n)\tO\nand\tO\nearnings\tT-2\nper\tO\nshare\tT-1\ndropped\tO\nto\tO\n40\tO\ncents\tO\nfrom\tO\n46\tO\ncents\tO\n.\tO\n\nNews\tO\nannounced\tT-0\npre-abnormals\tO\nnet\tO\nprofit\tO\nfor\tO\nthe\tO\nyear\tO\nfell\tO\nsix\tO\npercent\tO\nto\tO\nA$\tO\n1.26\tO\nbillion\tT-2\n(\tO\nUS$\tB-MISC\n995\tT-3\nmillion\tT-3\n)\tO\nand\tO\nearnings\tT-1\nper\tO\nshare\tO\ndropped\tO\nto\tO\n40\tO\ncents\tO\nfrom\tO\n46\tO\ncents\tO\n.\tT-2\n\nAnalysts\tT-0\nhad\tO\non\tO\naverage\tO\nexpected\tO\na\tO\npre-abnormals\tO\nprofit\tT-1\nof\tO\nA$\tB-MISC\n1.343\tO\nbillion\tO\n.\tO\n\n\"\tO\nThe\tO\nyear\tO\njust\tO\ngone\tO\nwas\tO\ndisappointing\tO\n,\tO\nbut\tO\nthe\tO\noutlook\tO\nfor\tO\nthe\tO\ncurrent\tO\nyear\tO\nlooks\tT-0\ngood\tO\n,\tO\n\"\tO\nFirst\tB-ORG\nPacific\tI-ORG\nmedia\tT-2\nanalyst\tO\nLachlan\tO\nDrummond\tO\nsaid\tT-1\n.\tO\n\n\"\tO\nThe\tO\nyear\tO\njust\tO\ngone\tO\nwas\tO\ndisappointing\tT-3\n,\tO\nbut\tO\nthe\tO\noutlook\tO\nfor\tO\nthe\tO\ncurrent\tO\nyear\tO\nlooks\tO\ngood\tT-0\n,\tO\n\"\tO\nFirst\tO\nPacific\tT-2\nmedia\tT-2\nanalyst\tT-2\nLachlan\tB-PER\nDrummond\tI-PER\nsaid\tT-1\n.\tO\n\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tO\nstrong\tO\nperformances\tT-2\nin\tO\nU.S.\tO\ntelevision\tO\nand\tO\nBritish\tO\nnewspapers\tO\nwere\tO\noffset\tO\nby\tO\nlower\tO\nprofits\tT-0\nfrom\tO\nNews\tO\nCorp\tO\n's\tO\nmagazine\tO\nand\tO\npublishing\tO\ndivisions\tO\nand\tO\nfurther\tO\nhefty\tO\nlosses\tT-1\nfrom\tO\nits\tO\nAsian\tO\nStar\tO\nTV\tO\noperations\tO\n.\tO\n\nNews\tO\nCorp\tO\nsaid\tO\nstrong\tO\nperformances\tT-1\nin\tO\nU.S.\tB-LOC\ntelevision\tO\nand\tO\nBritish\tO\nnewspapers\tO\nwere\tO\noffset\tT-3\nby\tO\nlower\tO\nprofits\tT-0\nfrom\tO\nNews\tO\nCorp\tO\n's\tO\nmagazine\tO\nand\tO\npublishing\tO\ndivisions\tO\nand\tO\nfurther\tO\nhefty\tO\nlosses\tT-2\nfrom\tO\nits\tO\nAsian\tO\nStar\tO\nTV\tO\noperations\tO\n.\tO\n\nNews\tT-0\nCorp\tT-0\nsaid\tO\nstrong\tO\nperformances\tO\nin\tO\nU.S.\tT-2\ntelevision\tT-2\nand\tT-2\nBritish\tB-MISC\nnewspapers\tT-3\nwere\tT-3\noffset\tT-3\nby\tT-3\nlower\tT-3\nprofits\tT-3\nfrom\tO\nNews\tT-1\nCorp\tT-1\n's\tO\nmagazine\tO\nand\tO\npublishing\tO\ndivisions\tO\nand\tO\nfurther\tO\nhefty\tO\nlosses\tO\nfrom\tO\nits\tO\nAsian\tO\nStar\tO\nTV\tO\noperations\tO\n.\tO\n\nNews\tO\nCorp\tO\nsaid\tT-0\nstrong\tO\nperformances\tO\nin\tO\nU.S.\tO\ntelevision\tO\nand\tO\nBritish\tO\nnewspapers\tO\nwere\tO\noffset\tO\nby\tO\nlower\tO\nprofits\tT-2\nfrom\tT-2\nNews\tB-ORG\nCorp\tI-ORG\n's\tO\nmagazine\tO\nand\tO\npublishing\tO\ndivisions\tT-1\nand\tO\nfurther\tO\nhefty\tO\nlosses\tO\nfrom\tO\nits\tO\nAsian\tO\nStar\tO\nTV\tO\noperations\tO\n.\tO\n\nNews\tO\nCorp\tO\nsaid\tO\nstrong\tO\nperformances\tO\nin\tO\nU.S.\tO\ntelevision\tO\nand\tO\nBritish\tO\nnewspapers\tO\nwere\tO\noffset\tO\nby\tO\nlower\tO\nprofits\tO\nfrom\tO\nNews\tO\nCorp\tO\n's\tO\nmagazine\tT-0\nand\tO\npublishing\tO\ndivisions\tO\nand\tO\nfurther\tO\nhefty\tO\nlosses\tO\nfrom\tO\nits\tO\nAsian\tB-ORG\nStar\tI-ORG\nTV\tI-ORG\noperations\tT-1\n.\tT-1\n\nThroughout\tO\nthe\tO\ngroup\tT-1\n,\tO\nhigher\tO\npaper\tO\nprices\tO\nincreased\tT-2\ncosts\tO\nby\tO\nover\tO\nUS$\tB-MISC\n300\tO\nmillion\tO\n,\tO\n\"\tO\nit\tO\nsaid\tT-0\n.\tO\n\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tT-2\nBritish\tO\nnewspaper\tT-1\noperating\tT-0\nprofits\tO\nrose\tO\n10\tO\npercent\tO\nfor\tO\nthe\tO\nyear\tO\n,\tO\nas\tO\nhigher\tO\ncover\tO\nprices\tO\nat\tT-3\nThe\tO\nSun\tO\nand\tO\nThe\tO\nTimes\tO\nand\tO\nhigher\tO\nadvertising\tO\nvolumes\tO\noffset\tO\nincreased\tO\nnewsprint\tO\ncosts\tO\n.\tO\n\nNews\tT-3\nCorp\tT-3\nsaid\tT-2\nBritish\tB-MISC\nnewspaper\tT-0\noperating\tO\nprofits\tT-1\nrose\tT-1\n10\tO\npercent\tO\nfor\tO\nthe\tO\nyear\tO\n,\tO\nas\tO\nhigher\tT-4\ncover\tO\nprices\tO\nat\tO\nThe\tO\nSun\tO\nand\tO\nThe\tO\nTimes\tO\nand\tO\nhigher\tO\nadvertising\tO\nvolumes\tO\noffset\tO\nincreased\tO\nnewsprint\tO\ncosts\tO\n.\tO\n\nNews\tO\nCorp\tO\nsaid\tO\nBritish\tO\nnewspaper\tO\noperating\tT-0\nprofits\tT-0\nrose\tT-0\n10\tO\npercent\tO\nfor\tO\nthe\tO\nyear\tO\n,\tO\nas\tO\nhigher\tO\ncover\tO\nprices\tT-2\nat\tO\nThe\tB-ORG\nSun\tI-ORG\nand\tO\nThe\tO\nTimes\tO\nand\tO\nhigher\tO\nadvertising\tO\nvolumes\tO\noffset\tO\nincreased\tT-1\nnewsprint\tT-1\ncosts\tT-1\n.\tO\n\nNews\tO\nCorp\tO\nsaid\tO\nBritish\tT-0\nnewspaper\tT-0\noperating\tO\nprofits\tO\nrose\tO\n10\tO\npercent\tO\nfor\tO\nthe\tO\nyear\tO\n,\tO\nas\tO\nhigher\tO\ncover\tO\nprices\tO\nat\tO\nThe\tO\nSun\tO\nand\tO\nThe\tB-ORG\nTimes\tI-ORG\nand\tO\nhigher\tO\nadvertising\tT-1\nvolumes\tO\noffset\tO\nincreased\tO\nnewsprint\tO\ncosts\tO\n.\tO\n\nAdvertising\tO\nrevenues\tT-0\nat\tO\nThe\tB-ORG\nTimes\tI-ORG\ngrew\tO\n20\tO\npercent\tO\n.\tO\n\nAnalysts\tO\nsaid\tO\nsharply\tO\nlower\tO\nearnings\tT-0\nfrom\tO\nNews\tB-ORG\nCorp\tI-ORG\n's\tO\nbook\tO\npublishing\tT-3\ndivision\tO\nand\tO\nits\tO\nU.S.\tT-2\nmagazines\tT-2\nhad\tO\nbeen\tO\nthe\tO\nmajor\tO\nsurprises\tT-1\nin\tO\nthe\tO\nresults\tO\nfor\tO\n1995/96\tO\n.\tO\n\nAnalysts\tO\nsaid\tO\nsharply\tO\nlower\tO\nearnings\tT-1\nfrom\tO\nNews\tO\nCorp\tO\n's\tO\nbook\tO\npublishing\tO\ndivision\tT-3\nand\tO\nits\tO\nU.S.\tB-LOC\nmagazines\tO\nhad\tO\nbeen\tO\nthe\tO\nmajor\tT-0\nsurprises\tT-0\nin\tO\nthe\tO\nresults\tT-2\nfor\tO\n1995/96\tO\n.\tO\n\nNews\tB-ORG\nCorp\tI-ORG\nsaid\tT-0\nrevenue\tT-2\ngains\tO\nat\tO\nits\tO\nmagazines\tT-1\nand\tO\ninserts\tO\ndivision\tO\nwere\tO\noffset\tO\nby\tO\nhigher\tO\npaper\tO\nprices\tO\nand\tO\nlower\tO\nsales\tO\nat\tO\nthe\tO\nU.S.\tO\nTV\tO\nGuide\tO\n.\tO\n\nNews\tO\nCorp\tO\nsaid\tO\nrevenue\tO\ngains\tO\nat\tO\nits\tO\nmagazines\tO\nand\tO\ninserts\tO\ndivision\tO\nwere\tO\noffset\tO\nby\tO\nhigher\tO\npaper\tO\nprices\tO\nand\tO\nlower\tO\nsales\tO\nat\tT-1\nthe\tT-1\nU.S.\tB-LOC\nTV\tT-0\nGuide\tT-0\n.\tO\n\nNews\tO\nCorp\tO\nsaid\tT-0\nrevenue\tO\ngains\tT-1\nat\tO\nits\tO\nmagazines\tO\nand\tO\ninserts\tO\ndivision\tO\nwere\tO\noffset\tO\nby\tO\nhigher\tO\npaper\tO\nprices\tT-2\nand\tO\nlower\tO\nsales\tO\nat\tO\nthe\tO\nU.S.\tO\nTV\tB-ORG\nGuide\tI-ORG\n.\tO\n\nNews\tB-ORG\nsaid\tT-0\ndramatically\tO\nlower\tT-1\nearnings\tT-3\nfrom\tO\nthe\tO\nBritish\tO\narm\tO\nof\tO\nits\tO\nHarper-Collins\tO\npublishing\tO\ndivision\tO\nmore\tO\nthan\tO\noffset\tO\nhealthy\tO\nresults\tT-2\nfrom\tO\nits\tO\nU.S.\tO\noperation\tO\n.\tO\n\nNews\tO\nsaid\tO\ndramatically\tO\nlower\tO\nearnings\tT-0\nfrom\tO\nthe\tO\nBritish\tB-MISC\narm\tO\nof\tO\nits\tO\nHarper-Collins\tT-2\npublishing\tO\ndivision\tO\nmore\tO\nthan\tO\noffset\tO\nhealthy\tO\nresults\tO\nfrom\tO\nits\tO\nU.S.\tT-3\noperation\tT-3\n.\tT-2\n\nNews\tO\nsaid\tO\ndramatically\tO\nlower\tO\nearnings\tO\nfrom\tO\nthe\tO\nBritish\tT-1\narm\tT-1\nof\tO\nits\tT-0\nHarper-Collins\tB-ORG\npublishing\tO\ndivision\tT-3\nmore\tO\nthan\tO\noffset\tO\nhealthy\tO\nresults\tO\nfrom\tO\nits\tO\nU.S.\tT-2\noperation\tT-2\n.\tT-2\n\nNews\tO\nsaid\tO\ndramatically\tO\nlower\tO\nearnings\tO\nfrom\tO\nthe\tO\nBritish\tO\narm\tO\nof\tO\nits\tO\nHarper-Collins\tT-0\npublishing\tO\ndivision\tO\nmore\tO\nthan\tO\noffset\tO\nhealthy\tO\nresults\tO\nfrom\tT-1\nits\tO\nU.S.\tB-LOC\noperation\tO\n.\tO\n\nIt\tO\nsaid\tT-0\nthe\tO\ndemise\tO\nof\tO\nthe\tO\nNet\tB-MISC\nBook\tI-MISC\nAgreement\tI-MISC\nhad\tO\nhurt\tO\nthe\tO\nBritish\tT-1\noperations\tT-3\n,\tO\nand\tO\nweak\tO\nperformances\tT-4\nfrom\tO\nthe\tO\nSan\tT-2\nFrancisco\tT-2\nunit\tO\nof\tO\nHarper-Collins\tO\nhad\tO\nnot\tO\nhelped\tO\n.\tO\n\nIt\tO\nsaid\tT-1\nthe\tO\ndemise\tO\nof\tO\nthe\tO\nNet\tO\nBook\tO\nAgreement\tO\nhad\tO\nhurt\tT-2\nthe\tO\nBritish\tB-MISC\noperations\tT-3\n,\tO\nand\tO\nweak\tO\nperformances\tT-0\nfrom\tO\nthe\tO\nSan\tO\nFrancisco\tO\nunit\tO\nof\tO\nHarper-Collins\tO\nhad\tO\nnot\tO\nhelped\tO\n.\tO\n\nIt\tO\nsaid\tO\nthe\tO\ndemise\tO\nof\tO\nthe\tO\nNet\tO\nBook\tO\nAgreement\tO\nhad\tO\nhurt\tO\nthe\tO\nBritish\tT-0\noperations\tO\n,\tO\nand\tO\nweak\tO\nperformances\tO\nfrom\tO\nthe\tO\nSan\tB-LOC\nFrancisco\tI-LOC\nunit\tT-1\nof\tO\nHarper-Collins\tO\nhad\tO\nnot\tT-2\nhelped\tT-2\n.\tO\n\nIt\tO\nsaid\tO\nthe\tO\ndemise\tO\nof\tO\nthe\tO\nNet\tO\nBook\tO\nAgreement\tO\nhad\tO\nhurt\tO\nthe\tO\nBritish\tO\noperations\tO\n,\tO\nand\tO\nweak\tO\nperformances\tO\nfrom\tO\nthe\tO\nSan\tT-1\nFrancisco\tT-1\nunit\tT-0\nof\tO\nHarper-Collins\tB-ORG\nhad\tO\nnot\tO\nhelped\tO\n.\tO\n\n\"\tO\nIf\tO\nthey\tO\n're\tO\nsaying\tO\nat\tO\nleast\tO\n20\tO\npercent\tO\n,\tO\nthen\tO\ntheir\tO\ninternal\tO\nforecasts\tO\nare\tO\nprobably\tO\nsaying\tO\n25\tO\nor\tO\n30\tO\npercent\tO\n,\tO\n\"\tO\nsaid\tO\none\tO\nSydney\tB-LOC\nmedia\tT-0\nanalyst\tT-0\nwho\tO\ndeclined\tO\nto\tO\nbe\tO\nnamed\tO\n.\tO\n\nNews\tB-ORG\nCorp\tI-ORG\n's\tO\nshares\tT-0\nwere\tO\ndown\tO\neight\tO\ncents\tO\nat\tO\nA$\tO\n6.39\tO\nat\tO\n2.00\tO\np.m.\tO\n(\tO\n0400\tO\nGMT\tO\n)\tO\nin\tO\na\tO\nsoft\tO\nmarket\tO\n.\tO\n\nNews\tO\nCorp\tO\n's\tO\nshares\tT-3\nwere\tO\ndown\tO\neight\tT-1\ncents\tT-1\nat\tT-1\nA$\tB-MISC\n6.39\tT-2\nat\tO\n2.00\tO\np.m.\tO\n(\tO\n0400\tO\nGMT\tO\n)\tO\nin\tO\na\tO\nsoft\tO\nmarket\tO\n.\tT-2\n\nNews\tT-0\nCorp\tT-0\n's\tO\nshares\tT-1\nwere\tO\ndown\tO\neight\tO\ncents\tO\nat\tO\nA$\tO\n6.39\tO\nat\tO\n2.00\tO\np.m.\tO\n(\tO\n0400\tO\nGMT\tB-MISC\n)\tO\nin\tO\na\tO\nsoft\tT-2\nmarket\tT-2\n.\tO\n\n(\tO\nA$\tT-0\n1\tT-0\n=\tO\nUS$\tB-MISC\n0.79\tO\n)\tO\n\nRTRS\tB-ORG\n-\tO\nBudget\tT-0\ncuts\tO\nto\tO\nboost\tO\nAustralia\tO\nsavings\tT-1\n-\tO\nRBA\tO\n.\tO\n\nRTRS\tO\n-\tO\nBudget\tO\ncuts\tO\nto\tO\nboost\tT-0\nAustralia\tB-LOC\nsavings\tT-1\n-\tO\nRBA\tO\n.\tO\n\nRTRS\tT-1\n-\tO\nBudget\tO\ncuts\tO\nto\tO\nboost\tO\nAustralia\tO\nsavings\tT-0\n-\tO\nRBA\tB-ORG\n.\tO\n\nThe\tT-0\nAustralian\tB-MISC\ngovernment\tT-1\n's\tT-1\nplans\tO\nto\tO\nslash\tT-2\nits\tO\nbudget\tO\ndeficit\tO\nshould\tO\nmake\tO\na\tO\nuseful\tO\ncontribution\tO\nto\tO\nnational\tO\nsavings\tO\n,\tO\nthe\tO\nReserve\tO\nBank\tO\nof\tO\nAustralia\tO\n(\tO\nRBA\tO\n)\tO\nsaid\tT-3\nin\tO\nits\tO\nannual\tT-4\nreport\tT-4\n.\tO\n\nThe\tO\nAustralian\tT-1\ngovernment\tT-1\n's\tT-1\nplans\tO\nto\tO\nslash\tO\nits\tO\nbudget\tT-2\ndeficit\tO\nshould\tO\nmake\tO\na\tO\nuseful\tO\ncontribution\tT-3\nto\tT-3\nnational\tT-3\nsavings\tT-3\n,\tO\nthe\tO\nReserve\tB-ORG\nBank\tI-ORG\nof\tI-ORG\nAustralia\tI-ORG\n(\tO\nRBA\tO\n)\tO\nsaid\tT-0\nin\tO\nits\tO\nannual\tO\nreport\tO\n.\tO\n\nThe\tO\nAustralian\tO\ngovernment\tT-2\n's\tO\nplans\tT-0\nto\tO\nslash\tO\nits\tO\nbudget\tO\ndeficit\tO\nshould\tO\nmake\tO\na\tO\nuseful\tO\ncontribution\tO\nto\tO\nnational\tO\nsavings\tO\n,\tO\nthe\tO\nReserve\tO\nBank\tO\nof\tO\nAustralia\tO\n(\tO\nRBA\tB-ORG\n)\tO\nsaid\tT-1\nin\tO\nits\tO\nannual\tO\nreport\tO\n.\tO\n\n\"\tO\nThe\tO\ngovernment\tO\n's\tO\nannounced\tT-0\nplans\tT-0\nto\tO\nbalance\tO\nthe\tO\nbudget\tO\n,\tO\nif\tO\nrealised\tO\n,\tO\nwould\tO\nmake\tO\na\tO\nuseful\tO\ncontribution\tT-2\nto\tO\nraising\tO\nnational\tO\nsavings\tO\n,\tO\n\"\tO\nthe\tO\nRBA\tB-ORG\nsaid\tT-1\n.\tO\n\nIn\tO\nits\tO\n1996/97\tO\nbudget\tO\nannounced\tO\non\tO\nTuesday\tO\n,\tO\nthe\tO\nAustralian\tB-MISC\nCoalition\tT-1\ngovernment\tT-1\nannounced\tO\nan\tO\nunderlying\tO\nbudget\tT-0\ndeficit\tO\nof\tO\nA$\tO\n5.65\tO\nbillion\tO\n,\tO\nand\tO\npledged\tO\nto\tO\nreturn\tO\nthe\tO\nunderlying\tO\nbudget\tO\nbalance\tO\nto\tO\nsurplus\tO\nby\tO\n1998/99\tO\n.\tO\n\nIn\tO\nits\tO\n1996/97\tO\nbudget\tO\nannounced\tT-1\non\tO\nTuesday\tO\n,\tO\nthe\tO\nAustralian\tT-2\nCoalition\tB-ORG\ngovernment\tO\nannounced\tO\nan\tO\nunderlying\tO\nbudget\tO\ndeficit\tO\nof\tO\nA$\tO\n5.65\tO\nbillion\tO\n,\tO\nand\tO\npledged\tT-0\nto\tO\nreturn\tO\nthe\tO\nunderlying\tO\nbudget\tO\nbalance\tO\nto\tO\nsurplus\tO\nby\tO\n1998/99\tO\n.\tO\n\nIn\tO\nits\tO\n1996/97\tO\nbudget\tO\nannounced\tO\non\tO\nTuesday\tO\n,\tO\nthe\tO\nAustralian\tO\nCoalition\tO\ngovernment\tO\nannounced\tO\nan\tO\nunderlying\tO\nbudget\tT-0\ndeficit\tT-0\nof\tO\nA$\tB-MISC\n5.65\tO\nbillion\tO\n,\tO\nand\tO\npledged\tT-1\nto\tO\nreturn\tO\nthe\tO\nunderlying\tO\nbudget\tO\nbalance\tO\nto\tO\nsurplus\tO\nby\tO\n1998/99\tO\n.\tO\n\nThe\tO\nbudget\tT-1\ndeficit\tT-1\nwas\tT-0\nA$\tB-MISC\n10.3\tO\nbillion\tO\nin\tO\n1995/96\tO\n.\tO\n\n\"\tO\nMore\tO\ngenerally\tO\n,\tO\nthe\tO\nlong-term\tO\neffects\tO\nof\tO\nfiscal\tO\nconsolidation\tO\nare\tO\nclearly\tO\npositive\tO\n,\tO\nwith\tO\nhigher\tO\nsaving\tO\ntending\tO\nto\tO\npromote\tT-0\neconomic\tT-0\ngrowth\tT-0\nby\tO\nraising\tO\ninvestment\tO\nand\tO\nlowering\tO\nlong-term\tO\nreal\tO\ninterest\tO\nrates\tO\n,\tO\n\"\tO\nthe\tT-1\nRBA\tB-ORG\nsaid\tO\n.\tO\n\nBNZ\tB-ORG\ncuts\tT-1\nNZ\tO\nfixed\tT-0\nhome\tT-0\nlending\tT-0\nrates\tT-0\n.\tO\n\nBNZ\tT-2\ncuts\tO\nNZ\tB-LOC\nfixed\tT-1\nhome\tT-0\nlending\tO\nrates\tO\n.\tO\n\nBank\tB-ORG\nof\tI-ORG\nNew\tI-ORG\nZealand\tI-ORG\nsaid\tO\non\tO\nThursday\tT-0\nit\tO\nwas\tO\ncutting\tT-1\nits\tO\nfixed\tO\nhome\tT-2\nlending\tT-2\nrates\tO\n.\tO\n\nBNZ\tB-ORG\nsaid\tT-1\nit\tO\nwas\tO\nresponding\tO\nto\tO\nlower\tO\nwholesale\tT-0\nrates\tO\n.\tO\n\n--\tO\nWellington\tB-LOC\nnewsroom\tT-0\n64\tT-1\n4\tT-1\n4734\tT-1\n746\tT-1\n\nPower\tB-ORG\nNZ\tI-ORG\nODV\tI-ORG\nup\tT-0\n8\tO\npct\tO\nat\tO\nNZ$\tT-1\n524\tO\nmillion\tO\n.\tT-1\n\nPower\tT-0\nNZ\tO\nODV\tO\nup\tO\n8\tO\npct\tO\nat\tO\nNZ$\tB-MISC\n524\tO\nmillion\tT-1\n.\tO\n\nPower\tB-ORG\nNew\tI-ORG\nZealand\tI-ORG\nsaid\tO\non\tO\nThursday\tO\nthat\tO\nthe\tO\nOptimised\tO\nDeprival\tO\nValue\tO\n(\tO\nODV\tO\n)\tO\nof\tO\nits\tT-0\nnetwork\tT-0\nat\tO\nMarch\tO\n31\tO\n,\tO\n1996\tO\nhas\tO\nbeen\tO\nset\tT-1\nat\tO\n$\tO\n524.2\tO\nmillion\tO\n,\tO\nan\tO\nincrease\tT-2\nof\tO\neight\tO\npercent\tO\non\tO\nits\tO\n$\tO\n486.5\tO\nmillion\tO\nvaluation\tO\na\tO\nyear\tO\nearlier\tO\n.\tO\n\nrequirements\tT-0\nof\tO\nthe\tO\nMinistry\tB-ORG\nof\tI-ORG\nCommerce\tI-ORG\n.\tO\n\n--\tO\nWellington\tB-LOC\nnewsroom\tT-0\n64\tT-1\n4\tT-1\n4734\tT-1\n746\tT-1\n\nThais\tO\nhunt\tT-0\nfor\tO\nAustralian\tB-MISC\njail\tO\nbreaker\tT-1\n.\tO\n\nThailand\tB-LOC\nhas\tT-0\nlaunched\tT-0\na\tO\nmanhunt\tO\nfor\tO\nan\tO\nAustralian\tT-1\nwho\tO\nescaped\tO\nfrom\tO\na\tO\nhigh\tO\nsecurity\tO\nprison\tO\nin\tT-2\nBangkok\tO\nwhile\tO\nawaiting\tO\ntrial\tO\non\tO\ndrug\tO\npossession\tO\ncharges\tO\n,\tO\nofficials\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThailand\tO\nhas\tO\nlaunched\tO\na\tO\nmanhunt\tT-0\nfor\tO\nan\tO\nAustralian\tB-MISC\nwho\tO\nescaped\tT-1\nfrom\tO\na\tO\nhigh\tO\nsecurity\tO\nprison\tO\nin\tO\nBangkok\tO\nwhile\tO\nawaiting\tO\ntrial\tO\non\tO\ndrug\tO\npossession\tO\ncharges\tO\n,\tO\nofficials\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nThailand\tO\nhas\tO\nlaunched\tO\na\tO\nmanhunt\tO\nfor\tO\nan\tO\nAustralian\tT-0\nwho\tO\nescaped\tO\nfrom\tO\na\tO\nhigh\tO\nsecurity\tO\nprison\tT-1\nin\tO\nBangkok\tB-LOC\nwhile\tO\nawaiting\tO\ntrial\tO\non\tO\ndrug\tO\npossession\tO\ncharges\tO\n,\tO\nofficials\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nDaniel\tB-PER\nWestlake\tI-PER\n,\tO\n46\tO\n,\tO\nfrom\tO\nVictoria\tT-0\n,\tO\nmade\tO\nthe\tO\nfirst\tO\nsucessful\tO\nescape\tT-2\nfrom\tO\nKlongprem\tO\nprison\tT-3\nin\tO\nthe\tO\nnorthern\tO\noutskirts\tO\nof\tO\nthe\tO\ncapital\tT-1\non\tO\nSunday\tO\nnight\tO\n.\tO\n\nDaniel\tT-2\nWestlake\tT-2\n,\tO\n46\tO\n,\tO\nfrom\tT-1\nVictoria\tB-LOC\n,\tO\nmade\tT-0\nthe\tO\nfirst\tO\nsucessful\tO\nescape\tO\nfrom\tO\nKlongprem\tT-3\nprison\tT-3\nin\tO\nthe\tO\nnorthern\tO\noutskirts\tO\nof\tO\nthe\tO\ncapital\tO\non\tO\nSunday\tO\nnight\tO\n.\tO\n\nDaniel\tO\nWestlake\tO\n,\tO\n46\tO\n,\tO\nfrom\tO\nVictoria\tO\n,\tO\nmade\tO\nthe\tO\nfirst\tO\nsucessful\tO\nescape\tT-1\nfrom\tT-1\nKlongprem\tB-LOC\nprison\tO\nin\tO\nthe\tO\nnorthern\tO\noutskirts\tO\nof\tO\nthe\tT-0\ncapital\tT-0\non\tO\nSunday\tO\nnight\tO\n.\tO\n\nHe\tO\nwas\tO\nbelieved\tT-0\nby\tO\nprison\tT-1\nofficials\tT-2\nto\tO\nstill\tO\nbe\tO\nin\tO\nThailand\tB-LOC\n.\tO\n\n\"\tO\nWe\tO\nhave\tO\nordered\tO\na\tO\nmassive\tO\nhunt\tT-0\nfor\tO\nhim\tO\nand\tO\nI\tO\nam\tO\nquite\tT-2\nconfident\tO\nwe\tO\nwill\tO\nget\tO\nhim\tO\nsoon\tO\n,\tO\n\"\tO\nVivit\tB-PER\nChatuparisut\tI-PER\n,\tO\ndeputy\tT-3\ndirector\tT-3\ngeneral\tO\nof\tO\nthe\tO\nCorrection\tT-1\nDepartment\tT-1\n,\tO\ntold\tO\nReuters\tO\n.\tO\n\n\"\tO\nWe\tO\nhave\tT-2\nordered\tT-2\na\tO\nmassive\tO\nhunt\tO\nfor\tO\nhim\tO\nand\tO\nI\tO\nam\tO\nquite\tO\nconfident\tO\nwe\tO\nwill\tO\nget\tO\nhim\tO\nsoon\tO\n,\tO\n\"\tO\nVivit\tO\nChatuparisut\tO\n,\tO\ndeputy\tO\ndirector\tO\ngeneral\tT-1\nof\tO\nthe\tO\nCorrection\tB-ORG\nDepartment\tI-ORG\n,\tO\ntold\tO\nReuters\tO\n.\tT-0\n\n\"\tO\nWe\tO\nhave\tO\nordered\tO\na\tO\nmassive\tO\nhunt\tO\nfor\tO\nhim\tO\nand\tO\nI\tO\nam\tO\nquite\tO\nconfident\tO\nwe\tO\nwill\tO\nget\tO\nhim\tO\nsoon\tO\n,\tO\n\"\tO\nVivit\tO\nChatuparisut\tO\n,\tO\ndeputy\tO\ndirector\tO\ngeneral\tO\nof\tO\nthe\tO\nCorrection\tT-0\nDepartment\tO\n,\tO\ntold\tO\nReuters\tB-ORG\n.\tO\n\nWestlake\tB-PER\n,\tO\narrested\tO\nin\tO\nDecember\tO\n1993\tO\nand\tO\ncharged\tT-0\nwith\tO\nheroin\tO\ntrafficking\tO\n,\tO\nsawed\tT-2\nthe\tO\niron\tO\ngrill\tO\noff\tO\nhis\tO\ncell\tO\nwindow\tO\nand\tO\nclimbed\tT-3\ndown\tO\nthe\tO\nprison\tO\n's\tO\nfive-metre\tO\n(\tO\n15-foot\tO\n)\tO\nwall\tO\non\tO\na\tO\nrope\tO\nmade\tO\nfrom\tO\nbed\tO\nsheets\tO\n,\tO\nVivit\tO\nsaid\tT-1\n.\tO\n\nThere\tT-2\nare\tT-2\n266\tT-2\nWesterners\tB-MISC\n,\tO\nincluding\tT-0\nsix\tO\nAustralians\tO\n,\tO\nin\tO\nthe\tO\nprison\tO\n,\tO\nmost\tO\nawaiting\tO\ntrial\tO\non\tO\ndrugs\tO\ncharges\tT-1\n.\tO\n\nThere\tO\nare\tO\n266\tO\nWesterners\tT-1\n,\tO\nincluding\tT-2\nsix\tT-2\nAustralians\tB-MISC\n,\tO\nin\tO\nthe\tO\nprison\tO\n,\tO\nmost\tO\nawaiting\tT-0\ntrial\tO\non\tO\ndrugs\tO\ncharges\tO\n.\tO\n\nThere\tO\nalso\tO\nare\tO\nabout\tO\n5,000\tO\nThai\tB-MISC\ninmates\tO\nin\tO\nKlongprem\tO\n,\tO\na\tO\nprison\tO\nofficial\tO\nsaid\tT-0\n.\tO\n\nThere\tO\nalso\tO\nare\tO\nabout\tO\n5,000\tO\nThai\tO\ninmates\tO\nin\tT-0\nKlongprem\tB-LOC\n,\tO\na\tT-1\nprison\tT-1\nofficial\tO\nsaid\tT-2\n.\tO\n\nTokyo\tB-ORG\nSoir\tI-ORG\n-\tO\n1996\tO\nparent\tO\nforecast\tT-0\n.\tO\n\nNOTE\tO\n-\tO\nTokyo\tB-ORG\nSoir\tI-ORG\nCo\tI-ORG\nLtd\tI-ORG\nis\tT-1\na\tO\nspecialised\tO\nmanufacturer\tO\nof\tO\nwomen\tO\n\"\tO\ns\tO\nformal\tT-0\nwear\tO\n.\tO\n\nKa\tB-ORG\nWah\tI-ORG\nBank\tI-ORG\nsets\tT-1\nHK$\tO\n43\tO\nmln\tO\nFRCD\tT-0\n.\tT-0\n\nKa\tO\nWah\tO\nBank\tO\nsets\tT-0\nHK$\tB-MISC\n43\tT-1\nmln\tT-1\nFRCD\tT-1\n.\tO\n\nKa\tB-ORG\nWah\tI-ORG\nBank\tI-ORG\n's\tO\nHK$\tO\n43\tO\nmillion\tT-0\nfloating\tT-1\nrate\tT-2\ncertificate\tO\nof\tO\ndeposit\tO\nissue\tO\nhas\tO\nbeen\tO\nprivately\tO\nplaced\tO\n,\tO\nsole\tO\narranger\tO\nHSBC\tO\nMarkets\tO\nsaid\tO\n.\tO\n\nKa\tO\nWah\tO\nBank\tO\n's\tO\nHK$\tB-MISC\n43\tO\nmillion\tO\nfloating\tO\nrate\tO\ncertificate\tO\nof\tO\ndeposit\tO\nissue\tT-0\nhas\tO\nbeen\tO\nprivately\tO\nplaced\tT-1\n,\tO\nsole\tO\narranger\tO\nHSBC\tT-2\nMarkets\tO\nsaid\tO\n.\tO\n\nKa\tO\nWah\tO\nBank\tO\n's\tO\nHK$\tO\n43\tO\nmillion\tO\nfloating\tO\nrate\tO\ncertificate\tO\nof\tO\ndeposit\tO\nissue\tO\nhas\tO\nbeen\tO\nprivately\tO\nplaced\tO\n,\tO\nsole\tT-0\narranger\tT-0\nHSBC\tB-ORG\nMarkets\tI-ORG\nsaid\tT-1\n.\tO\n\nIt\tO\npays\tT-0\na\tO\ncoupon\tO\nof\tO\n15\tO\nbasis\tO\npoints\tO\nover\tT-1\nthe\tT-1\nsix-month\tT-1\nHong\tB-ORG\nKong\tI-ORG\nInterbank\tI-ORG\nOffered\tT-2\nRate\tT-2\n.\tO\n\nClearing\tT-0\nis\tO\nthrough\tO\nthe\tO\nHong\tB-ORG\nKong\tI-ORG\nCentral\tI-ORG\nMoneymarkets\tI-ORG\nUnit\tI-ORG\n.\tO\n\nMalaysia\tB-LOC\nbans\tT-0\nnitrofuran\tO\nusage\tO\nin\tO\nchicken\tO\nfeed\tO\n.\tO\n\nMalaysia\tB-LOC\nhas\tO\nbanned\tT-3\nthe\tO\nuse\tO\nof\tO\nnitrofuran\tT-0\n,\tO\nan\tO\nantibiotic\tO\n,\tO\nin\tO\nchicken\tT-1\nfeed\tO\nand\tO\nveterinary\tT-2\napplications\tO\nbecause\tO\nit\tO\nbelieves\tO\nthe\tO\ndrug\tO\ncould\tO\ncause\tO\ncancer\tO\n,\tO\nthe\tO\nhealth\tO\nministry\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nIt\tO\nis\tO\nhoped\tO\nthat\tO\nlivestock\tO\nbreeders\tO\nand\tO\nfeedmillers\tO\nwill\tO\nabide\tO\nby\tO\nthe\tO\nlaws\tO\nand\tO\nrespect\tO\nthe\tO\ncabinet\tO\ndecision\tO\nin\tO\nthe\tO\ninterest\tO\nof\tO\nconsumer\tO\nsafety\tO\n,\tO\n\"\tO\nHealth\tO\nMinister\tT-0\nChua\tB-PER\nJui\tI-PER\nMeng\tO\nwas\tO\nquoted\tO\nas\tO\nsaying\tO\nby\tO\nthe\tO\nnational\tO\nBernama\tO\nnews\tO\nagency\tO\n.\tO\n\n\"\tO\nIt\tO\nis\tO\nhoped\tT-2\nthat\tO\nlivestock\tO\nbreeders\tO\nand\tO\nfeedmillers\tO\nwill\tO\nabide\tO\nby\tO\nthe\tO\nlaws\tO\nand\tO\nrespect\tO\nthe\tO\ncabinet\tO\ndecision\tO\nin\tO\nthe\tO\ninterest\tO\nof\tO\nconsumer\tO\nsafety\tO\n,\tO\n\"\tO\nHealth\tO\nMinister\tO\nChua\tO\nJui\tO\nMeng\tO\nwas\tT-0\nquoted\tT-0\nas\tT-0\nsaying\tT-0\nby\tT-0\nthe\tT-0\nnational\tT-0\nBernama\tB-ORG\nnews\tT-1\nagency\tT-1\n.\tO\n\nChua\tB-PER\nsaid\tT-0\noffenders\tO\ncould\tO\nface\tO\na\tO\ntwo-year\tO\nprison\tO\nsentence\tO\nand\tO\na\tO\nmaximum\tO\nfine\tO\nof\tO\n5,000\tO\nringgit\tO\n(\tO\n$\tO\n2000\tO\n)\tO\n.\tO\n\nINDONESIAN\tB-MISC\nSTOCKS\tT-1\n-\tO\nfactors\tT-2\nto\tO\nwatch\tT-0\n-\tO\nAugust\tO\n22\tO\n.\tO\n\nFollowing\tO\nare\tO\nsome\tO\nof\tO\nthe\tO\nmain\tO\nfactors\tO\nlikely\tO\nto\tO\naffect\tT-0\nIndonesian\tB-MISC\nstocks\tT-1\non\tO\nThursday\tO\n:\tO\n\n**\tO\nSecurity\tO\nwas\tT-1\ntight\tT-1\nin\tT-0\nJakarta\tB-LOC\nahead\tO\nof\tO\na\tO\ntrial\tT-2\ninvolving\tO\nousted\tO\nIndonesian\tO\nDemocratic\tO\nParty\tO\nleader\tO\nMegawati\tO\nSukarnoputri\tO\n.\tT-2\n\n**\tO\nSecurity\tO\nwas\tO\ntight\tO\nin\tO\nJakarta\tO\nahead\tO\nof\tO\na\tO\ntrial\tO\ninvolving\tO\nousted\tT-0\nIndonesian\tB-ORG\nDemocratic\tI-ORG\nParty\tI-ORG\nleader\tO\nMegawati\tT-1\nSukarnoputri\tT-1\n.\tO\n\n**\tO\nSecurity\tO\nwas\tO\ntight\tT-1\nin\tO\nJakarta\tO\nahead\tO\nof\tO\na\tO\ntrial\tO\ninvolving\tO\nousted\tO\nIndonesian\tO\nDemocratic\tO\nParty\tO\nleader\tT-0\nMegawati\tB-PER\nSukarnoputri\tI-PER\n.\tO\n\nAround\tO\n200\tO\npolice\tO\nand\tO\ntroops\tO\nwere\tO\nstationed\tO\noutside\tT-1\nthe\tO\ncourt\tT-0\nin\tO\ncentral\tO\nJakarta\tB-LOC\nbut\tO\nthere\tO\nwas\tO\nno\tO\nsign\tO\nof\tO\ndemonstrators\tO\n.\tO\n\n**\tO\nThe\tO\nDow\tB-MISC\nJones\tI-MISC\nindustrial\tT-0\naverage\tO\nclosed\tO\ndown\tO\n31.44\tO\npoints\tO\nat\tO\n5,689.82\tO\non\tO\nWednesday\tO\n,\tO\nending\tO\na\tO\nthree-session\tO\nwinning\tO\nstreak\tO\nas\tO\ninvestors\tO\ntook\tO\nprofits\tT-1\nand\tO\ntobacco\tT-2\nstocks\tT-3\ntook\tO\na\tO\nbeating\tO\n.\tO\n\n**\tO\nThe\tO\nJakarta\tB-LOC\ncomposite\tT-2\nindex\tO\nrose\tT-0\n2.60\tO\npoints\tO\n,\tO\nor\tO\n0.48\tO\npercent\tO\n,\tO\nto\tO\n542.20\tO\npoints\tO\non\tO\nWednesday\tO\non\tO\nthe\tO\nback\tO\nof\tO\nbargain-hunting\tT-1\nin\tO\nselected\tO\nbig-capitalised\tO\nstocks\tO\nand\tO\nsecondliners\tO\n.\tO\n\n**\tO\nOn\tO\nThursday\tO\n,\tO\nthe\tO\nIndonesian\tB-MISC\nrupiah\tO\nwas\tO\nat\tO\n2,343.00\tO\n/\tO\n43.50\tO\nin\tO\nearly\tO\ntrading\tO\nagainst\tT-0\nan\tO\nopening\tO\nof\tO\n2,342.75\tO\n/\tO\n43.50\tO\n.\tO\n\n**\tO\nPackaging\tO\nmanufacturer\tT-0\nSuper\tB-ORG\nIndah\tI-ORG\nMakmur\tI-ORG\non\tO\nannouncement\tO\nof\tO\na\tO\ntender\tO\noffer\tO\nby\tO\nPT\tO\nVDH\tO\nTeguh\tO\nSakti\tO\n,\tO\na\tO\nwholly-owned\tO\nsubsidiary\tO\nof\tO\nSingapore-listed\tO\nVan\tO\nDer\tO\nHorst\tO\n.\tO\n\n**\tO\nPackaging\tO\nmanufacturer\tT-1\nSuper\tT-2\nIndah\tT-2\nMakmur\tT-2\non\tO\nannouncement\tO\nof\tO\na\tO\ntender\tO\noffer\tT-0\nby\tT-0\nPT\tB-ORG\nVDH\tI-ORG\nTeguh\tI-ORG\nSakti\tI-ORG\n,\tO\na\tO\nwholly-owned\tO\nsubsidiary\tO\nof\tO\nSingapore-listed\tO\nVan\tO\nDer\tO\nHorst\tO\n.\tO\n\n**\tO\nPackaging\tO\nmanufacturer\tO\nSuper\tO\nIndah\tO\nMakmur\tO\non\tO\nannouncement\tO\nof\tO\na\tO\ntender\tO\noffer\tO\nby\tO\nPT\tO\nVDH\tO\nTeguh\tO\nSakti\tO\n,\tO\na\tO\nwholly-owned\tT-0\nsubsidiary\tT-1\nof\tT-1\nSingapore-listed\tB-MISC\nVan\tT-2\nDer\tT-2\nHorst\tT-2\n.\tO\n\n**\tO\nPackaging\tO\nmanufacturer\tT-3\nSuper\tT-0\nIndah\tT-0\nMakmur\tT-0\non\tO\nannouncement\tO\nof\tO\na\tO\ntender\tO\noffer\tO\nby\tO\nPT\tT-1\nVDH\tT-1\nTeguh\tT-1\nSakti\tT-1\n,\tO\na\tO\nwholly-owned\tO\nsubsidiary\tO\nof\tO\nSingapore-listed\tT-2\nVan\tB-ORG\nDer\tI-ORG\nHorst\tI-ORG\n.\tO\n\n**\tO\nPrivately-owned\tT-2\nBank\tB-ORG\nDuta\tI-ORG\non\tO\nmarket\tO\ntalk\tO\nthat\tO\nit\tO\nis\tO\nobtaining\tT-1\nfresh\tO\nsyndicated\tT-0\nloans\tO\n,\tO\na\tO\nmanagement\tO\nreshuffle\tO\nand\tO\nfresh\tO\nequity\tO\ninjection\tO\n.\tO\n\n**\tO\nCiputra\tB-ORG\nDevelopment\tI-ORG\non\tO\nreports\tT-2\nof\tO\na\tO\nplan\tO\nto\tO\nbuild\tO\nproperty\tO\nprojects\tO\nworth\tO\n$\tO\n2\tO\nbillion\tO\nin\tO\nJakarta\tT-0\nand\tO\nSurabaya\tT-1\n.\tO\n\n**\tO\nCiputra\tO\nDevelopment\tO\non\tO\nreports\tT-1\nof\tO\na\tO\nplan\tO\nto\tO\nbuild\tO\nproperty\tT-0\nprojects\tT-2\nworth\tT-2\n$\tO\n2\tO\nbillion\tO\nin\tO\nJakarta\tB-LOC\nand\tO\nSurabaya\tT-3\n.\tO\n\n**\tO\nCiputra\tO\nDevelopment\tO\non\tO\nreports\tO\nof\tO\na\tO\nplan\tO\nto\tO\nbuild\tO\nproperty\tO\nprojects\tO\nworth\tO\n$\tO\n2\tO\nbillion\tO\nin\tT-1\nJakarta\tT-0\nand\tT-2\nSurabaya\tB-LOC\n.\tO\n\nKey\tO\nstock\tO\nand\tO\ncurrency\tO\nmarket\tO\nmovements\tT-0\nat\tO\n1600\tO\nGMT\tB-MISC\n.\tO\n\nAlso\tO\nshown\tO\nare\tO\nthe\tT-0\nLondon\tB-LOC\nclosing\tT-2\nvalues\tO\nof\tO\nthe\tO\nGerman\tO\nmark\tO\n,\tO\nthe\tO\nJapanese\tT-1\nyen\tO\n,\tO\nthe\tO\nBritish\tO\npound\tO\nand\tO\ngold\tO\nbullion\tO\n(\tO\nprevious\tO\nday\tO\n's\tO\ncloses\tO\nin\tO\nbrackets\tO\n)\tO\n:\tO\n\nAlso\tO\nshown\tO\nare\tO\nthe\tO\nLondon\tO\nclosing\tT-2\nvalues\tT-0\nof\tO\nthe\tO\nGerman\tB-MISC\nmark\tT-1\n,\tO\nthe\tO\nJapanese\tO\nyen\tO\n,\tO\nthe\tO\nBritish\tO\npound\tO\nand\tO\ngold\tO\nbullion\tO\n(\tO\nprevious\tO\nday\tO\n's\tO\ncloses\tT-3\nin\tO\nbrackets\tO\n)\tO\n:\tO\n\nAlso\tO\nshown\tO\nare\tO\nthe\tO\nLondon\tT-1\nclosing\tT-0\nvalues\tT-0\nof\tO\nthe\tO\nGerman\tO\nmark\tO\n,\tO\nthe\tO\nJapanese\tB-MISC\nyen\tO\n,\tO\nthe\tO\nBritish\tT-2\npound\tO\nand\tO\ngold\tO\nbullion\tO\n(\tO\nprevious\tO\nday\tO\n's\tO\ncloses\tO\nin\tO\nbrackets\tO\n)\tO\n:\tO\n\nAlso\tO\nshown\tO\nare\tO\nthe\tO\nLondon\tO\nclosing\tO\nvalues\tO\nof\tO\nthe\tO\nGerman\tO\nmark\tO\n,\tO\nthe\tO\nJapanese\tO\nyen\tO\n,\tO\nthe\tT-1\nBritish\tB-MISC\npound\tT-0\nand\tO\ngold\tO\nbullion\tO\n(\tO\nprevious\tO\nday\tO\n's\tO\ncloses\tO\nin\tO\nbrackets\tO\n)\tO\n:\tO\n\nLONDON\tB-LOC\n3,907.5\tT-1\n+16.4\tO\n3,907.5\tO\n3,632.3\tT-0\n\nTOKYO\tB-LOC\n21,228.80\tT-0\n-\tT-0\n134.44\tT-0\n22,666.80\tT-0\n19,734.70\tT-0\n\nFRANKFURT\tB-LOC\n2,555.16\tT-0\n-\tO\n2.10\tO\n2,583.49\tO\n)\tO\n2,284.86\tO\n\nPARIS\tB-LOC\n2,020.82\tT-0\n+3.06\tT-0\n2,146.79\tT-0\n1,897.85\tT-0\n\nHONG\tB-LOC\nKONG\tI-LOC\n11,424.64\tT-0\n-\tT-0\n54.13\tT-0\n11,594.99\tT-0\n10,204.87\tT-0\n\nFOREIGN\tT-1\nEXCHANGE\tT-1\n/\tO\nGOLD\tO\nBULLION\tO\nCLOSE\tT-0\nIN\tO\nLONDON\tB-LOC\n\nNew\tB-LOC\nYork\tI-LOC\nDow\tO\nJones\tO\nindustrial\tT-0\naverage\tO\n--\tO\n5,778.00\tO\n(\tO\nMay\tO\n22/96\tO\n)\tO\n\nNew\tT-0\nYork\tT-0\nDow\tB-MISC\nJones\tI-MISC\nindustrial\tT-1\naverage\tO\n--\tO\n5,778.00\tO\n(\tO\nMay\tO\n22/96\tO\n)\tO\n\nLondon\tB-LOC\nFTSE-100\tT-0\nindex\tT-0\n--\tO\n3,907.5\tO\n(\tO\nAug\tO\n23/96\tO\n)\tO\n\nLondon\tO\nFTSE-100\tB-MISC\nindex\tT-0\n--\tO\n3,907.5\tO\n(\tO\nAug\tO\n23/96\tO\n)\tO\n\nTokyo\tB-LOC\nNikkei\tT-0\naverage\tO\n--\tO\n38,915.87\tT-1\n(\tO\nDec\tO\n29/89\tO\n)\tO\n\nTokyo\tT-0\nNikkei\tB-MISC\naverage\tO\n--\tO\n38,915.87\tO\n(\tO\nDec\tO\n29/89\tO\n)\tO\n\nFrankfurt\tB-LOC\nDAX-3O\tO\nindex\tO\n--\tO\n2,583.49\tT-0\n(\tO\nJul\tO\n5/96\tO\n)\tO\n\nFrankfurt\tO\nDAX-3O\tB-MISC\nindex\tT-0\n--\tO\n2,583.49\tO\n(\tO\nJul\tO\n5/96\tO\n)\tO\n\nParis\tB-LOC\nCAC-40\tT-0\nGeneral\tT-0\nindex\tT-0\n--\tO\n2,355.93\tO\n(\tO\nFeb\tO\n2/94\tO\n)\tO\n\nParis\tT-0\nCAC-40\tB-MISC\nGeneral\tI-MISC\nindex\tT-1\n--\tO\n2,355.93\tO\n(\tO\nFeb\tO\n2/94\tO\n)\tO\n\nSydney\tB-LOC\nAustralian\tO\nAll-Ordinaries\tO\nindex\tT-0\n--\tO\n2,340.6\tO\n(\tO\nFeb\tO\n3/94\tO\n)\tO\n\nSydney\tT-1\nAustralian\tB-MISC\nAll-Ordinaries\tI-MISC\nindex\tT-0\n--\tO\n2,340.6\tO\n(\tO\nFeb\tO\n3/94\tO\n)\tO\n\nHong\tB-LOC\nKong\tI-LOC\nHang\tT-0\nSeng\tT-0\nindex\tO\n--\tO\n12,201.09\tO\n(\tO\nJan\tO\n4/94\tO\n)\tO\n\nHong\tT-0\nKong\tT-0\nHang\tB-MISC\nSeng\tI-MISC\nindex\tT-2\n--\tT-2\n12,201.09\tT-2\n(\tT-2\nJan\tT-2\n4/94\tT-2\n)\tT-2\n\nUkraine\tB-LOC\nhails\tT-1\npeace\tT-1\nas\tO\nmarks\tT-2\nfive-year\tT-2\nindependence\tT-2\n.\tO\n\nUkraine\tB-LOC\ncelebrates\tT-0\nfive\tO\nyears\tO\nof\tO\nindependence\tO\nfrom\tO\nKremlin\tO\nrule\tT-2\non\tO\nSaturday\tO\n,\tO\nhailing\tO\ncivil\tT-1\nand\tO\ninter-ethnic\tO\npeace\tT-3\nas\tO\nits\tO\nmain\tO\npost-Soviet\tO\nachievement\tT-4\n.\tO\n\nUkraine\tT-2\ncelebrates\tO\nfive\tO\nyears\tO\nof\tO\nindependence\tO\nfrom\tT-1\nKremlin\tB-LOC\nrule\tT-3\non\tO\nSaturday\tT-4\n,\tO\nhailing\tO\ncivil\tO\nand\tO\ninter-ethnic\tO\npeace\tO\nas\tO\nits\tO\nmain\tO\npost-Soviet\tT-0\nachievement\tO\n.\tO\n\nUkraine\tT-2\ncelebrates\tO\nfive\tT-0\nyears\tT-0\nof\tT-0\nindependence\tT-0\nfrom\tO\nKremlin\tT-3\nrule\tO\non\tO\nSaturday\tO\n,\tO\nhailing\tO\ncivil\tO\nand\tO\ninter-ethnic\tO\npeace\tO\nas\tO\nits\tO\nmain\tO\npost-Soviet\tB-MISC\nachievement\tT-1\n.\tO\n\nUkraine\tB-LOC\n's\tO\ndeclaration\tO\nof\tO\nindependence\tO\nin\tO\n1991\tO\n,\tO\nbacked\tO\nnine-to-one\tO\nby\tO\na\tO\nreferendum\tO\nin\tO\nDecember\tO\nof\tO\nthat\tO\nyear\tO\n,\tO\neffectively\tO\ndealt\tO\na\tO\ndeath\tO\nblow\tT-0\nto\tO\nthe\tO\nSoviet\tO\nempire\tO\nand\tO\nended\tT-1\nmore\tO\nthan\tO\nthree\tO\ncenturies\tO\nof\tO\nrule\tO\nfrom\tO\nMoscow\tO\n.\tO\n\nUkraine\tO\n's\tO\ndeclaration\tT-1\nof\tO\nindependence\tO\nin\tO\n1991\tO\n,\tO\nbacked\tO\nnine-to-one\tO\nby\tO\na\tO\nreferendum\tO\nin\tO\nDecember\tO\nof\tO\nthat\tO\nyear\tO\n,\tO\neffectively\tO\ndealt\tO\na\tO\ndeath\tO\nblow\tO\nto\tO\nthe\tO\nSoviet\tB-MISC\nempire\tT-0\nand\tO\nended\tO\nmore\tO\nthan\tO\nthree\tO\ncenturies\tO\nof\tO\nrule\tO\nfrom\tO\nMoscow\tO\n.\tO\n\nUkraine\tO\n's\tO\ndeclaration\tT-0\nof\tO\nindependence\tO\nin\tO\n1991\tO\n,\tO\nbacked\tO\nnine-to-one\tO\nby\tO\na\tO\nreferendum\tT-2\nin\tO\nDecember\tO\nof\tO\nthat\tO\nyear\tO\n,\tO\neffectively\tO\ndealt\tO\na\tO\ndeath\tO\nblow\tO\nto\tO\nthe\tO\nSoviet\tT-1\nempire\tT-1\nand\tO\nended\tO\nmore\tO\nthan\tO\nthree\tO\ncenturies\tO\nof\tO\nrule\tT-3\nfrom\tT-3\nMoscow\tB-LOC\n.\tO\n\nUkraine\tB-LOC\n,\tO\nwith\tO\na\tO\nRussian\tT-1\ncommunity\tT-1\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tO\nRussia\tO\n--\tO\nhas\tO\navoided\tO\nconflicts\tO\nlike\tO\nthose\tO\nin\tO\nRussia\tO\n's\tO\nChechnya\tO\n,\tO\nneighbouring\tT-0\nMoldova\tT-0\n,\tO\nand\tO\nthe\tO\nformer\tO\nSoviet\tO\nrepublics\tO\nof\tO\nGeorgia\tO\n,\tO\nAzerbaijan\tO\nand\tO\nTajikistan\tO\n.\tO\n\nUkraine\tO\n,\tO\nwith\tO\na\tO\nRussian\tB-MISC\ncommunity\tT-1\nof\tO\n11\tT-0\nmillion\tT-0\npeople\tT-0\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tO\nRussia\tO\n--\tO\nhas\tO\navoided\tO\nconflicts\tT-2\nlike\tO\nthose\tO\nin\tO\nRussia\tO\n's\tO\nChechnya\tO\n,\tO\nneighbouring\tO\nMoldova\tO\n,\tO\nand\tO\nthe\tO\nformer\tO\nSoviet\tO\nrepublics\tO\nof\tO\nGeorgia\tO\n,\tO\nAzerbaijan\tO\nand\tO\nTajikistan\tO\n.\tO\n\nUkraine\tO\n,\tO\nwith\tO\na\tO\nRussian\tO\ncommunity\tO\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tT-0\n's\tT-0\nlargest\tT-0\noutside\tT-0\nRussia\tB-LOC\n--\tO\nhas\tT-1\navoided\tT-1\nconflicts\tO\nlike\tO\nthose\tO\nin\tO\nRussia\tO\n's\tO\nChechnya\tO\n,\tO\nneighbouring\tO\nMoldova\tO\n,\tO\nand\tO\nthe\tO\nformer\tO\nSoviet\tO\nrepublics\tO\nof\tO\nGeorgia\tO\n,\tO\nAzerbaijan\tO\nand\tO\nTajikistan\tO\n.\tO\n\nUkraine\tO\n,\tO\nwith\tO\na\tO\nRussian\tO\ncommunity\tT-1\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tO\nRussia\tO\n--\tO\nhas\tO\navoided\tT-0\nconflicts\tO\nlike\tO\nthose\tO\nin\tO\nRussia\tB-LOC\n's\tO\nChechnya\tT-2\n,\tO\nneighbouring\tO\nMoldova\tO\n,\tO\nand\tO\nthe\tO\nformer\tO\nSoviet\tO\nrepublics\tO\nof\tO\nGeorgia\tO\n,\tO\nAzerbaijan\tO\nand\tO\nTajikistan\tO\n.\tO\n\nUkraine\tO\n,\tO\nwith\tO\na\tO\nRussian\tO\ncommunity\tO\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tO\nRussia\tO\n--\tO\nhas\tO\navoided\tT-2\nconflicts\tO\nlike\tT-0\nthose\tT-0\nin\tT-0\nRussia\tO\n's\tO\nChechnya\tB-LOC\n,\tO\nneighbouring\tT-1\nMoldova\tO\n,\tO\nand\tO\nthe\tO\nformer\tO\nSoviet\tO\nrepublics\tO\nof\tO\nGeorgia\tO\n,\tO\nAzerbaijan\tO\nand\tO\nTajikistan\tO\n.\tO\n\nUkraine\tO\n,\tO\nwith\tO\na\tO\nRussian\tT-0\ncommunity\tT-0\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tT-2\nRussia\tO\n--\tO\nhas\tO\navoided\tT-3\nconflicts\tO\nlike\tO\nthose\tO\nin\tO\nRussia\tO\n's\tO\nChechnya\tO\n,\tO\nneighbouring\tT-1\nMoldova\tB-LOC\n,\tO\nand\tO\nthe\tO\nformer\tO\nSoviet\tO\nrepublics\tO\nof\tO\nGeorgia\tO\n,\tO\nAzerbaijan\tO\nand\tO\nTajikistan\tO\n.\tO\n\nUkraine\tO\n,\tO\nwith\tO\na\tO\nRussian\tO\ncommunity\tO\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tO\nRussia\tO\n--\tO\nhas\tT-1\navoided\tT-1\nconflicts\tO\nlike\tO\nthose\tO\nin\tO\nRussia\tO\n's\tO\nChechnya\tO\n,\tO\nneighbouring\tO\nMoldova\tO\n,\tO\nand\tO\nthe\tO\nformer\tT-0\nSoviet\tB-MISC\nrepublics\tO\nof\tO\nGeorgia\tO\n,\tO\nAzerbaijan\tO\nand\tO\nTajikistan\tO\n.\tO\n\nUkraine\tO\n,\tO\nwith\tO\na\tO\nRussian\tO\ncommunity\tO\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tO\nRussia\tO\n--\tO\nhas\tO\navoided\tT-3\nconflicts\tO\nlike\tO\nthose\tO\nin\tO\nRussia\tO\n's\tO\nChechnya\tO\n,\tO\nneighbouring\tO\nMoldova\tO\n,\tO\nand\tO\nthe\tO\nformer\tO\nSoviet\tT-0\nrepublics\tT-4\nof\tO\nGeorgia\tB-LOC\n,\tO\nAzerbaijan\tT-1\nand\tO\nTajikistan\tT-2\n.\tO\n\nUkraine\tO\n,\tO\nwith\tO\na\tO\nRussian\tO\ncommunity\tO\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tT-0\nRussia\tO\n--\tO\nhas\tO\navoided\tT-1\nconflicts\tO\nlike\tO\nthose\tO\nin\tO\nRussia\tO\n's\tO\nChechnya\tO\n,\tO\nneighbouring\tO\nMoldova\tO\n,\tO\nand\tO\nthe\tO\nformer\tT-2\nSoviet\tT-2\nrepublics\tT-2\nof\tO\nGeorgia\tO\n,\tO\nAzerbaijan\tB-LOC\nand\tO\nTajikistan\tO\n.\tO\n\nUkraine\tO\n,\tO\nwith\tO\na\tO\nRussian\tO\ncommunity\tO\nof\tO\n11\tO\nmillion\tO\npeople\tO\n--\tO\nthe\tO\nworld\tO\n's\tO\nlargest\tO\noutside\tO\nRussia\tO\n--\tO\nhas\tT-1\navoided\tT-2\nconflicts\tO\nlike\tO\nthose\tO\nin\tO\nRussia\tO\n's\tO\nChechnya\tO\n,\tO\nneighbouring\tO\nMoldova\tO\n,\tO\nand\tO\nthe\tO\nformer\tT-0\nSoviet\tT-0\nrepublics\tT-0\nof\tO\nGeorgia\tO\n,\tO\nAzerbaijan\tO\nand\tO\nTajikistan\tB-LOC\n.\tO\n\n\"\tO\nUkraine\tB-LOC\n's\tO\nbiggest\tO\nachievements\tT-2\nfor\tO\nfive\tO\nyears\tO\nare\tO\nthe\tO\npreservation\tO\nof\tO\ncivil\tO\npeace\tO\nand\tO\ninter-ethnic\tO\nharmony\tO\n,\tO\n\"\tO\nPresident\tT-1\nLeonid\tT-1\nKuchma\tT-1\nsaid\tT-0\nin\tO\ntelevised\tO\nstatement\tO\nthis\tO\nweek\tO\n.\tO\n\n\"\tO\nUkraine\tT-2\n's\tO\nbiggest\tO\nachievements\tO\nfor\tO\nfive\tO\nyears\tO\nare\tO\nthe\tO\npreservation\tO\nof\tO\ncivil\tO\npeace\tO\nand\tO\ninter-ethnic\tO\nharmony\tO\n,\tO\n\"\tO\nPresident\tT-0\nLeonid\tB-PER\nKuchma\tI-PER\nsaid\tT-1\nin\tO\ntelevised\tO\nstatement\tO\nthis\tO\nweek\tO\n.\tO\n\n\"\tO\nUnlike\tO\nmany\tO\nother\tO\npost-Soviet\tB-MISC\ncountries\tT-2\nwe\tO\nwere\tO\nable\tO\nto\tO\ndeal\tT-3\nwith\tO\nconflict\tO\nsituations\tO\nin\tO\na\tO\npeaceful\tT-0\nand\tO\ncivilised\tT-1\nway\tO\n.\tO\n\"\tO\n\nKuchma\tB-PER\ntold\tT-1\na\tO\nsolemn\tT-3\nceremony\tO\nat\tO\nthe\tO\nUkraina\tO\nPalace\tO\non\tO\nFriday\tO\nthat\tO\n\"\tO\nthere\tO\nwas\tO\na\tO\nturning\tO\npoint\tO\n\"\tO\nin\tO\nreforms\tO\nand\tO\nthat\tO\nhe\tT-2\nexpected\tT-2\na\tO\nrise\tO\nin\tO\nthe\tO\nstandard\tO\nof\tO\nliving\tO\nin\tO\nthe\tO\nnear\tO\nfuture\tO\n.\tO\n\nKuchma\tO\ntold\tO\na\tO\nsolemn\tO\nceremony\tO\nat\tO\nthe\tO\nUkraina\tB-LOC\nPalace\tI-LOC\non\tO\nFriday\tO\nthat\tO\n\"\tO\nthere\tO\nwas\tO\na\tO\nturning\tO\npoint\tO\n\"\tO\nin\tO\nreforms\tT-0\nand\tO\nthat\tO\nhe\tO\nexpected\tO\na\tO\nrise\tT-1\nin\tO\nthe\tO\nstandard\tT-2\nof\tT-2\nliving\tT-2\nin\tO\nthe\tO\nnear\tO\nfuture\tO\n.\tO\n\n\"\tO\nThere\tO\nis\tO\nno\tO\ndoubt\tO\nthat\tO\neconomic\tT-0\ngrowth\tT-0\nhas\tO\nalready\tO\nstarted\tO\n,\tO\n\"\tO\nsaid\tT-1\nAdelbert\tB-PER\nKnobl\tI-PER\n,\tO\nhead\tT-2\nof\tT-2\nthe\tT-2\nInternational\tO\nMonetary\tO\nFund\tO\n's\tO\nmission\tO\nin\tO\nUkraine\tO\n.\tO\n\"\tO\n\n\"\tO\nThere\tO\nis\tO\nno\tO\ndoubt\tO\nthat\tO\neconomic\tT-3\ngrowth\tT-0\nhas\tO\nalready\tO\nstarted\tO\n,\tO\n\"\tO\nsaid\tO\nAdelbert\tO\nKnobl\tO\n,\tO\nhead\tT-1\nof\tT-1\nthe\tT-1\nInternational\tB-ORG\nMonetary\tI-ORG\nFund\tI-ORG\n's\tO\nmission\tT-2\nin\tO\nUkraine\tT-4\n.\tO\n\"\tO\n\n\"\tO\nThere\tO\nis\tO\nno\tO\ndoubt\tO\nthat\tO\neconomic\tO\ngrowth\tO\nhas\tO\nalready\tO\nstarted\tO\n,\tO\n\"\tO\nsaid\tO\nAdelbert\tT-0\nKnobl\tT-0\n,\tO\nhead\tT-1\nof\tT-1\nthe\tT-1\nInternational\tT-1\nMonetary\tT-1\nFund\tT-1\n's\tO\nmission\tO\nin\tO\nUkraine\tB-LOC\n.\tO\n\"\tO\n\nIt\tO\nwill\tO\nreplace\tO\nthe\tO\ninterim\tO\nkarbovanets\tO\ncurrency\tO\n,\tO\nwhich\tO\nwas\tO\nintroduced\tT-0\nat\tO\npar\tO\nto\tO\nthe\tO\nRussian\tB-MISC\nrouble\tT-1\nin\tT-1\n1992\tT-1\nbut\tO\nnow\tO\ntrades\tO\nat\tO\nalmost\tO\n33\tO\nkarbovanets\tO\nper\tO\nrouble\tO\n.\tO\n\nUkraine\tB-LOC\nhas\tO\nrepeatedly\tT-0\npromised\tT-1\nto\tT-1\nintroduce\tT-1\nthe\tO\nhryvna\tO\nbut\tO\nhad\tO\nto\tO\npostpone\tO\nthe\tO\nplans\tO\nbecause\tO\nof\tO\neconomic\tO\nproblems\tO\n.\tO\n\nProud\tO\nof\tO\nits\tO\nrecord\tO\nin\tO\npromptly\tO\njoining\tT-0\nboth\tO\nthe\tO\nCouncil\tB-ORG\nof\tI-ORG\nEurope\tI-ORG\nand\tO\nNATO\tO\n's\tO\nPartnership\tO\nfor\tO\nPeace\tT-1\n,\tO\nUkraine\tT-4\ncaused\tO\na\tO\nforeign\tO\npolicy\tT-2\nwrangle\tO\nthis\tO\nweek\tO\n,\tO\noffending\tO\nChina\tO\nby\tO\nallowing\tT-3\na\tO\nTaiwanese\tO\nminister\tO\nto\tO\nappear\tO\non\tO\na\tO\npublic\tT-5\n,\tO\nif\tO\nunofficial\tO\nvisit\tO\n.\tO\n\nProud\tO\nof\tO\nits\tO\nrecord\tO\nin\tO\npromptly\tT-2\njoining\tO\nboth\tO\nthe\tO\nCouncil\tT-0\nof\tT-0\nEurope\tT-0\nand\tO\nNATO\tB-ORG\n's\tT-1\nPartnership\tO\nfor\tO\nPeace\tO\n,\tO\nUkraine\tO\ncaused\tO\na\tO\nforeign\tO\npolicy\tO\nwrangle\tO\nthis\tO\nweek\tO\n,\tO\noffending\tT-3\nChina\tO\nby\tO\nallowing\tO\na\tO\nTaiwanese\tO\nminister\tO\nto\tO\nappear\tO\non\tO\na\tO\npublic\tO\n,\tO\nif\tO\nunofficial\tO\nvisit\tO\n.\tO\n\nProud\tO\nof\tO\nits\tO\nrecord\tO\nin\tO\npromptly\tO\njoining\tO\nboth\tO\nthe\tO\nCouncil\tO\nof\tO\nEurope\tO\nand\tO\nNATO\tO\n's\tO\nPartnership\tB-MISC\nfor\tI-MISC\nPeace\tI-MISC\n,\tO\nUkraine\tT-0\ncaused\tO\na\tO\nforeign\tO\npolicy\tO\nwrangle\tO\nthis\tO\nweek\tO\n,\tO\noffending\tO\nChina\tO\nby\tO\nallowing\tO\na\tO\nTaiwanese\tO\nminister\tO\nto\tO\nappear\tO\non\tO\na\tO\npublic\tO\n,\tO\nif\tO\nunofficial\tT-1\nvisit\tO\n.\tO\n\nProud\tO\nof\tO\nits\tO\nrecord\tO\nin\tO\npromptly\tO\njoining\tO\nboth\tO\nthe\tO\nCouncil\tO\nof\tO\nEurope\tO\nand\tO\nNATO\tT-2\n's\tO\nPartnership\tO\nfor\tO\nPeace\tO\n,\tO\nUkraine\tB-LOC\ncaused\tT-0\na\tO\nforeign\tO\npolicy\tO\nwrangle\tO\nthis\tO\nweek\tO\n,\tO\noffending\tO\nChina\tO\nby\tO\nallowing\tO\na\tO\nTaiwanese\tO\nminister\tO\nto\tO\nappear\tO\non\tO\na\tO\npublic\tO\n,\tO\nif\tO\nunofficial\tO\nvisit\tT-1\n.\tO\n\nProud\tO\nof\tO\nits\tO\nrecord\tT-1\nin\tO\npromptly\tO\njoining\tO\nboth\tO\nthe\tO\nCouncil\tT-2\nof\tT-2\nEurope\tT-2\nand\tT-2\nNATO\tT-2\n's\tO\nPartnership\tO\nfor\tO\nPeace\tO\n,\tO\nUkraine\tT-3\ncaused\tO\na\tO\nforeign\tO\npolicy\tO\nwrangle\tO\nthis\tO\nweek\tO\n,\tO\noffending\tT-0\nChina\tB-LOC\nby\tO\nallowing\tO\na\tO\nTaiwanese\tT-4\nminister\tT-4\nto\tO\nappear\tO\non\tO\na\tO\npublic\tO\n,\tO\nif\tO\nunofficial\tO\nvisit\tO\n.\tO\n\nProud\tO\nof\tO\nits\tO\nrecord\tO\nin\tO\npromptly\tO\njoining\tO\nboth\tO\nthe\tO\nCouncil\tO\nof\tO\nEurope\tO\nand\tO\nNATO\tO\n's\tO\nPartnership\tO\nfor\tO\nPeace\tO\n,\tO\nUkraine\tT-2\ncaused\tO\na\tO\nforeign\tO\npolicy\tO\nwrangle\tO\nthis\tO\nweek\tO\n,\tO\noffending\tO\nChina\tO\nby\tO\nallowing\tO\na\tO\nTaiwanese\tB-MISC\nminister\tT-0\nto\tO\nappear\tT-1\non\tO\na\tO\npublic\tT-3\n,\tO\nif\tO\nunofficial\tO\nvisit\tO\n.\tO\n\nChina\tB-LOC\ncancelled\tT-1\na\tO\nvisit\tO\nby\tO\na\tO\ntop-level\tT-0\ndelegation\tT-0\nin\tO\nprotest\tO\n.\tO\n\nKiev\tB-LOC\n's\tO\nForeign\tT-0\nMinister\tT-0\nHennady\tT-0\nUdovenko\tT-0\nsaid\tT-1\nBeijing\tO\nwas\tO\noverreacting\tT-2\n.\tO\n\nKiev\tT-1\n's\tO\nForeign\tO\nMinister\tO\nHennady\tB-PER\nUdovenko\tI-PER\nsaid\tT-0\nBeijing\tT-2\nwas\tO\noverreacting\tT-3\n.\tO\n\nBut\tO\nUkraine\tB-LOC\n,\tO\nseeing\tT-2\nitself\tT-2\nas\tO\na\tO\nbridge\tT-3\nbetween\tO\nRussia\tT-0\nand\tO\nthe\tO\nrapidly\tO\nWesternising\tO\ncountries\tO\nof\tO\neastern\tT-1\nEurope\tT-1\n,\tO\nis\tO\nlooking\tO\nWest\tO\nas\tO\nwell\tO\nas\tO\nEast\tO\n.\tO\n\nBut\tO\nUkraine\tO\n,\tO\nseeing\tO\nitself\tO\nas\tO\na\tO\nbridge\tT-0\nbetween\tO\nRussia\tB-LOC\nand\tO\nthe\tO\nrapidly\tO\nWesternising\tT-1\ncountries\tO\nof\tO\neastern\tO\nEurope\tO\n,\tO\nis\tO\nlooking\tO\nWest\tO\nas\tO\nwell\tO\nas\tO\nEast\tO\n.\tT-2\n\nBut\tO\nUkraine\tT-3\n,\tO\nseeing\tO\nitself\tO\nas\tO\na\tO\nbridge\tO\nbetween\tO\nRussia\tT-4\nand\tO\nthe\tO\nrapidly\tT-0\nWesternising\tB-MISC\ncountries\tT-1\nof\tO\neastern\tT-2\nEurope\tT-2\n,\tO\nis\tO\nlooking\tO\nWest\tO\nas\tO\nwell\tO\nas\tO\nEast\tO\n.\tO\n\nBut\tO\nUkraine\tO\n,\tO\nseeing\tT-1\nitself\tO\nas\tO\na\tO\nbridge\tO\nbetween\tO\nRussia\tO\nand\tO\nthe\tO\nrapidly\tO\nWesternising\tO\ncountries\tT-3\nof\tO\neastern\tT-0\nEurope\tB-LOC\n,\tO\nis\tO\nlooking\tT-2\nWest\tO\nas\tO\nwell\tO\nas\tO\nEast\tT-4\n.\tO\n\n\"\tO\nThe\tO\nstrategic\tT-0\naim\tO\nof\tO\nEuropean\tB-MISC\nintegration\tO\nshould\tO\nnot\tO\nin\tO\nany\tO\nway\tO\ndamage\tO\nUkraine\tO\n's\tO\ninterests\tO\nin\tO\npost-Soviet\tO\nareas\tO\n.\tO\n\n\"\tO\nThe\tO\nstrategic\tO\naim\tO\nof\tO\nEuropean\tO\nintegration\tO\nshould\tO\nnot\tO\nin\tO\nany\tO\nway\tO\ndamage\tT-1\nUkraine\tB-LOC\n's\tO\ninterests\tT-0\nin\tO\npost-Soviet\tO\nareas\tT-2\n.\tO\n\n\"\tO\nThe\tO\nstrategic\tO\naim\tO\nof\tO\nEuropean\tT-0\nintegration\tT-0\nshould\tO\nnot\tO\nin\tO\nany\tO\nway\tO\ndamage\tT-1\nUkraine\tT-2\n's\tO\ninterests\tT-3\nin\tO\npost-Soviet\tB-MISC\nareas\tO\n.\tO\n\nRelations\tT-0\nwith\tT-1\nRussia\tB-LOC\n,\tO\nwhich\tO\nis\tO\nour\tO\nmain\tO\npartner\tO\n,\tO\nhave\tO\ngreat\tO\nimportance\tO\n,\tO\n\"\tO\nKuchma\tO\nsaid\tO\n.\tO\n\nRelations\tT-3\nwith\tO\nRussia\tT-1\n,\tO\nwhich\tO\nis\tO\nour\tO\nmain\tT-2\npartner\tT-2\n,\tO\nhave\tO\ngreat\tO\nimportance\tO\n,\tO\n\"\tO\nKuchma\tB-PER\nsaid\tT-0\n.\tO\n\n\"\tO\nBut\tO\nUkraine\tB-LOC\ncannot\tO\nbe\tO\neconomically\tO\noriented\tO\non\tO\nRussia\tT-0\n,\tO\neven\tO\nthough\tO\nthose\tO\nin\tO\nsome\tO\ncircles\tO\npush\tO\nus\tO\nto\tO\ndo\tO\nthat\tO\n.\tO\n\"\tO\n\n\"\tO\nBut\tO\nUkraine\tO\ncannot\tO\nbe\tO\neconomically\tT-0\noriented\tO\non\tT-1\nRussia\tB-LOC\n,\tO\neven\tO\nthough\tO\nthose\tO\nin\tO\nsome\tO\ncircles\tO\npush\tO\nus\tO\nto\tO\ndo\tO\nthat\tO\n.\tO\n\"\tO\n\nKuchma\tB-PER\nhas\tO\nsaid\tT-2\nKiev\tT-0\nwants\tO\nmembership\tO\nof\tO\nthe\tO\nEuropean\tO\nUnion\tO\n,\tO\nassociate\tO\nmembership\tO\nof\tO\nthe\tO\nWestern\tO\nEuropean\tO\nUnion\tO\ndefence\tO\ngrouping\tO\nand\tO\nto\tO\nmove\tO\ncloser\tT-1\nto\tO\nNATO\tO\n.\tO\n\nKuchma\tO\nhas\tO\nsaid\tT-0\nKiev\tB-LOC\nwants\tO\nmembership\tO\nof\tO\nthe\tO\nEuropean\tT-2\nUnion\tT-2\n,\tO\nassociate\tO\nmembership\tO\nof\tO\nthe\tO\nWestern\tT-1\nEuropean\tT-1\nUnion\tT-1\ndefence\tO\ngrouping\tO\nand\tO\nto\tO\nmove\tO\ncloser\tO\nto\tO\nNATO\tO\n.\tO\n\nKuchma\tT-0\nhas\tO\nsaid\tO\nKiev\tO\nwants\tO\nmembership\tT-1\nof\tT-1\nthe\tT-1\nEuropean\tB-ORG\nUnion\tI-ORG\n,\tO\nassociate\tO\nmembership\tO\nof\tO\nthe\tO\nWestern\tO\nEuropean\tO\nUnion\tO\ndefence\tO\ngrouping\tO\nand\tO\nto\tO\nmove\tO\ncloser\tO\nto\tO\nNATO\tO\n.\tO\n\nKuchma\tT-1\nhas\tO\nsaid\tO\nKiev\tO\nwants\tT-0\nmembership\tO\nof\tO\nthe\tO\nEuropean\tO\nUnion\tO\n,\tO\nassociate\tO\nmembership\tO\nof\tO\nthe\tO\nWestern\tB-ORG\nEuropean\tI-ORG\nUnion\tI-ORG\ndefence\tO\ngrouping\tO\nand\tO\nto\tO\nmove\tO\ncloser\tO\nto\tO\nNATO\tO\n.\tO\n\nKuchma\tT-2\nhas\tO\nsaid\tT-4\nKiev\tT-3\nwants\tO\nmembership\tT-0\nof\tO\nthe\tO\nEuropean\tO\nUnion\tO\n,\tO\nassociate\tO\nmembership\tO\nof\tO\nthe\tO\nWestern\tO\nEuropean\tO\nUnion\tO\ndefence\tO\ngrouping\tO\nand\tO\nto\tO\nmove\tT-1\ncloser\tO\nto\tO\nNATO\tB-ORG\n.\tO\n\nA\tO\nmessage\tO\nfrom\tO\nthe\tO\nWest\tO\nthis\tO\nweek\tO\nfrom\tT-2\nU.S.\tB-LOC\nPresident\tT-3\nBill\tT-3\nClinton\tT-3\ncongratulated\tO\nUkraine\tO\non\tO\nthe\tO\nanniversary\tT-0\n,\tO\npromising\tO\nto\tO\nsupport\tO\nmarket\tT-1\nreforms\tO\nand\tO\npraising\tO\nUkraine\tO\nas\tO\na\tO\n\"\tO\nstabilising\tO\nfactor\tO\n\"\tO\nin\tO\na\tO\nunited\tO\nEurope\tO\n.\tO\n\nA\tO\nmessage\tO\nfrom\tO\nthe\tO\nWest\tO\nthis\tO\nweek\tO\nfrom\tO\nU.S.\tO\nPresident\tO\nBill\tB-PER\nClinton\tI-PER\ncongratulated\tT-1\nUkraine\tO\non\tO\nthe\tO\nanniversary\tO\n,\tO\npromising\tO\nto\tO\nsupport\tT-0\nmarket\tO\nreforms\tO\nand\tO\npraising\tO\nUkraine\tO\nas\tO\na\tO\n\"\tO\nstabilising\tO\nfactor\tO\n\"\tO\nin\tO\na\tO\nunited\tO\nEurope\tO\n.\tO\n\nA\tO\nmessage\tO\nfrom\tO\nthe\tO\nWest\tT-3\nthis\tO\nweek\tO\nfrom\tO\nU.S.\tT-4\nPresident\tT-7\nBill\tO\nClinton\tO\ncongratulated\tT-0\nUkraine\tB-LOC\non\tO\nthe\tO\nanniversary\tT-1\n,\tO\npromising\tO\nto\tO\nsupport\tO\nmarket\tO\nreforms\tO\nand\tO\npraising\tO\nUkraine\tT-5\nas\tO\na\tO\n\"\tO\nstabilising\tT-2\nfactor\tT-2\n\"\tO\nin\tO\na\tO\nunited\tO\nEurope\tT-6\n.\tO\n\nA\tO\nmessage\tO\nfrom\tO\nthe\tO\nWest\tO\nthis\tO\nweek\tO\nfrom\tO\nU.S.\tO\nPresident\tO\nBill\tO\nClinton\tO\ncongratulated\tO\nUkraine\tO\non\tO\nthe\tO\nanniversary\tO\n,\tO\npromising\tO\nto\tO\nsupport\tO\nmarket\tO\nreforms\tO\nand\tO\npraising\tO\nUkraine\tB-LOC\nas\tO\na\tO\n\"\tO\nstabilising\tT-0\nfactor\tT-0\n\"\tO\nin\tO\na\tO\nunited\tO\nEurope\tO\n.\tO\n\nA\tO\nmessage\tO\nfrom\tO\nthe\tO\nWest\tO\nthis\tO\nweek\tO\nfrom\tO\nU.S.\tO\nPresident\tO\nBill\tO\nClinton\tO\ncongratulated\tT-1\nUkraine\tO\non\tO\nthe\tO\nanniversary\tO\n,\tO\npromising\tO\nto\tO\nsupport\tO\nmarket\tO\nreforms\tO\nand\tO\npraising\tO\nUkraine\tT-0\nas\tO\na\tO\n\"\tO\nstabilising\tO\nfactor\tO\n\"\tO\nin\tO\na\tO\nunited\tO\nEurope\tB-LOC\n.\tO\n\nOldest\tT-1\nAlbania\tB-LOC\nbook\tT-0\ndisappears\tO\nfrom\tO\nVatican\tT-2\n-\tO\npaper\tO\n.\tO\n\nOldest\tO\nAlbania\tT-2\nbook\tT-2\ndisappears\tO\nfrom\tT-0\nVatican\tB-LOC\n-\tT-1\npaper\tT-1\n.\tO\n\nA\tT-1\n16th-century\tT-1\ndocument\tT-1\n,\tO\nthe\tO\nearliest\tO\ncomplete\tO\nexample\tO\nof\tO\nwritten\tO\nAlbanian\tB-MISC\n,\tO\nhas\tT-4\ndisappeared\tT-4\nfrom\tO\nthe\tO\nVatican\tT-2\narchives\tT-2\n,\tO\nan\tO\nAlbanian\tT-0\nnewspaper\tT-3\nsaid\tT-3\non\tO\nFriday\tO\n.\tO\n\nA\tO\n16th-century\tO\ndocument\tO\n,\tO\nthe\tO\nearliest\tO\ncomplete\tT-3\nexample\tO\nof\tO\nwritten\tO\nAlbanian\tT-2\n,\tO\nhas\tO\ndisappeared\tO\nfrom\tT-0\nthe\tT-0\nVatican\tB-LOC\narchives\tT-1\n,\tO\nan\tO\nAlbanian\tO\nnewspaper\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nA\tO\n16th-century\tO\ndocument\tO\n,\tO\nthe\tO\nearliest\tO\ncomplete\tO\nexample\tO\nof\tO\nwritten\tO\nAlbanian\tT-3\n,\tO\nhas\tO\ndisappeared\tO\nfrom\tO\nthe\tO\nVatican\tT-1\narchives\tO\n,\tO\nan\tO\nAlbanian\tB-MISC\nnewspaper\tT-2\nsaid\tT-0\non\tO\nFriday\tO\n.\tO\n\nGazeta\tB-ORG\nShqiptare\tI-ORG\nsaid\tO\nthe\tO\n\"\tO\nBook\tT-0\nof\tT-0\nMass\tT-0\n'\tO\n,\tO\nby\tO\nGjon\tT-1\nBuzuku\tT-1\n,\tO\ndating\tO\nfrom\tO\n1555\tO\nand\tO\ndiscovered\tO\nin\tO\n1740\tO\nin\tO\na\tO\nreligious\tO\nseminary\tO\nin\tO\nRome\tO\n,\tO\nwas\tO\nthe\tO\nfirst\tO\nmajor\tO\ndocument\tO\npublished\tO\nin\tO\nthe\tO\nAlbanian\tO\nlanguage\tO\n.\tO\n\nGazeta\tO\nShqiptare\tO\nsaid\tO\nthe\tO\n\"\tO\nBook\tB-MISC\nof\tI-MISC\nMass\tI-MISC\n'\tO\n,\tO\nby\tO\nGjon\tO\nBuzuku\tO\n,\tO\ndating\tO\nfrom\tO\n1555\tO\nand\tO\ndiscovered\tT-0\nin\tO\n1740\tO\nin\tO\na\tO\nreligious\tO\nseminary\tO\nin\tO\nRome\tO\n,\tO\nwas\tO\nthe\tO\nfirst\tO\nmajor\tO\ndocument\tO\npublished\tO\nin\tO\nthe\tO\nAlbanian\tO\nlanguage\tO\n.\tT-1\n\nGazeta\tO\nShqiptare\tO\nsaid\tT-0\nthe\tO\n\"\tO\nBook\tT-2\nof\tT-2\nMass\tT-2\n'\tO\n,\tO\nby\tO\nGjon\tB-PER\nBuzuku\tI-PER\n,\tO\ndating\tO\nfrom\tO\n1555\tO\nand\tO\ndiscovered\tT-1\nin\tO\n1740\tO\nin\tO\na\tO\nreligious\tO\nseminary\tO\nin\tO\nRome\tO\n,\tO\nwas\tO\nthe\tO\nfirst\tO\nmajor\tO\ndocument\tO\npublished\tO\nin\tO\nthe\tO\nAlbanian\tO\nlanguage\tO\n.\tO\n\nGazeta\tO\nShqiptare\tO\nsaid\tO\nthe\tO\n\"\tO\nBook\tO\nof\tO\nMass\tO\n'\tO\n,\tO\nby\tO\nGjon\tO\nBuzuku\tO\n,\tO\ndating\tO\nfrom\tO\n1555\tO\nand\tO\ndiscovered\tT-2\nin\tO\n1740\tO\nin\tO\na\tO\nreligious\tO\nseminary\tT-0\nin\tT-1\nRome\tB-LOC\n,\tO\nwas\tO\nthe\tO\nfirst\tO\nmajor\tO\ndocument\tO\npublished\tO\nin\tO\nthe\tO\nAlbanian\tO\nlanguage\tO\n.\tO\n\nGazeta\tO\nShqiptare\tO\nsaid\tT-1\nthe\tO\n\"\tO\nBook\tO\nof\tO\nMass\tO\n'\tO\n,\tO\nby\tO\nGjon\tO\nBuzuku\tO\n,\tO\ndating\tO\nfrom\tO\n1555\tO\nand\tO\ndiscovered\tT-2\nin\tO\n1740\tO\nin\tO\na\tO\nreligious\tO\nseminary\tO\nin\tO\nRome\tO\n,\tO\nwas\tO\nthe\tO\nfirst\tO\nmajor\tO\ndocument\tT-4\npublished\tT-3\nin\tO\nthe\tO\nAlbanian\tB-MISC\nlanguage\tT-0\n.\tO\n\n\"\tO\nWe\tO\nAlbanians\tB-MISC\n,\tO\nsons\tT-0\nof\tT-0\nBuzuku\tT-0\n,\tO\nbelieved\tT-2\nour\tO\nlanguage\tO\nhad\tO\na\tO\nwritten\tO\ndocument\tT-1\nbut\tO\nnow\tO\nwe\tO\ndo\tO\nnot\tO\nhave\tO\nit\tO\nany\tO\nmore\tO\n,\tO\n\"\tO\nlamented\tO\nscholar\tO\nMusa\tO\nHamiti\tO\n,\tO\ntold\tT-3\nof\tO\nthe\tO\nloss\tO\nby\tO\nthe\tO\nVatican\tO\nlibrary\tO\n.\tO\n\n\"\tO\nWe\tO\nAlbanians\tO\n,\tO\nsons\tT-0\nof\tO\nBuzuku\tB-MISC\n,\tO\nbelieved\tO\nour\tO\nlanguage\tT-1\nhad\tO\na\tO\nwritten\tO\ndocument\tO\nbut\tO\nnow\tO\nwe\tO\ndo\tO\nnot\tO\nhave\tO\nit\tO\nany\tO\nmore\tO\n,\tO\n\"\tO\nlamented\tT-2\nscholar\tO\nMusa\tO\nHamiti\tO\n,\tO\ntold\tO\nof\tO\nthe\tO\nloss\tO\nby\tO\nthe\tO\nVatican\tO\nlibrary\tO\n.\tO\n\n\"\tO\nWe\tO\nAlbanians\tO\n,\tO\nsons\tO\nof\tO\nBuzuku\tO\n,\tO\nbelieved\tO\nour\tO\nlanguage\tO\nhad\tO\na\tO\nwritten\tO\ndocument\tO\nbut\tO\nnow\tO\nwe\tO\ndo\tO\nnot\tO\nhave\tO\nit\tO\nany\tO\nmore\tO\n,\tO\n\"\tO\nlamented\tT-0\nscholar\tO\nMusa\tB-PER\nHamiti\tI-PER\n,\tO\ntold\tO\nof\tO\nthe\tO\nloss\tO\nby\tO\nthe\tO\nVatican\tO\nlibrary\tO\n.\tO\n\n\"\tO\nWe\tO\nAlbanians\tO\n,\tO\nsons\tO\nof\tO\nBuzuku\tO\n,\tO\nbelieved\tT-0\nour\tT-0\nlanguage\tT-0\nhad\tO\na\tO\nwritten\tO\ndocument\tO\nbut\tO\nnow\tO\nwe\tO\ndo\tO\nnot\tO\nhave\tO\nit\tO\nany\tO\nmore\tO\n,\tO\n\"\tO\nlamented\tO\nscholar\tO\nMusa\tO\nHamiti\tO\n,\tO\ntold\tO\nof\tO\nthe\tO\nloss\tO\nby\tO\nthe\tO\nVatican\tB-LOC\nlibrary\tT-1\n.\tO\n\nTirana\tB-LOC\n's\tO\nnational\tO\nlibrary\tT-0\nhas\tO\nthree\tO\ncopies\tO\nof\tO\nthe\tO\n\"\tO\nBook\tO\nof\tO\nMass\tO\n'\tO\n.\tO\n\"\tO\n\nTirana\tO\n's\tO\nnational\tT-1\nlibrary\tO\nhas\tO\nthree\tO\ncopies\tT-0\nof\tO\nthe\tO\n\"\tO\nBook\tB-MISC\nof\tI-MISC\nMass\tI-MISC\n'\tO\n.\tO\n\"\tO\n\nThere\tO\nis\tO\nnothing\tO\nleft\tO\nfor\tO\nus\tO\nbut\tO\nto\tO\nbe\tO\ngrateful\tO\nto\tO\ncivilisation\tO\nfor\tO\ninventing\tT-1\nphotocopies\tT-2\n,\tO\n\"\tO\nGazeta\tB-ORG\nShqiptare\tI-ORG\nsaid\tT-0\n.\tO\n\nRussian\tB-MISC\nofficials\tO\n,\tO\nkeen\tO\nto\tO\ncut\tT-1\ncapital\tO\nflight\tO\n,\tO\nwill\tO\nadopt\tO\ntight\tO\nmeasures\tT-0\nto\tO\ncut\tO\nbarter\tO\ndeals\tO\nin\tO\nforeign\tO\ntrade\tO\nto\tO\na\tO\nminimum\tO\n,\tO\na\tO\ncustoms\tO\nofficial\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\n\"\tO\nWe\tO\nhave\tO\nalways\tO\nbeen\tO\nconcerned\tO\nabout\tO\nbarter\tO\ndeals\tO\nwith\tO\nother\tO\ncountries\tO\n,\tO\nviewing\tO\nthem\tO\nas\tO\na\tO\ndisguised\tO\nkind\tO\nof\tO\ncapital\tT-1\nflight\tT-1\nfrom\tT-1\nRussia\tB-LOC\n,\tO\n\"\tO\nMarina\tO\nVolkova\tO\n,\tO\ndeputy\tO\nhead\tO\nof\tO\nthe\tO\ncurrency\tO\ndepartment\tO\nat\tO\nthe\tO\nState\tT-0\nCustoms\tT-0\nCommittee\tT-0\n,\tO\ntold\tO\nReuters\tO\n.\tO\n\n\"\tO\nWe\tO\nhave\tO\nalways\tO\nbeen\tO\nconcerned\tO\nabout\tO\nbarter\tO\ndeals\tO\nwith\tO\nother\tO\ncountries\tO\n,\tO\nviewing\tO\nthem\tO\nas\tO\na\tO\ndisguised\tO\nkind\tO\nof\tO\ncapital\tT-0\nflight\tT-0\nfrom\tT-0\nRussia\tT-0\n,\tO\n\"\tO\nMarina\tB-PER\nVolkova\tI-PER\n,\tO\ndeputy\tT-4\nhead\tT-4\nof\tO\nthe\tO\ncurrency\tT-1\ndepartment\tT-1\nat\tO\nthe\tO\nState\tT-3\nCustoms\tT-3\nCommittee\tT-3\n,\tO\ntold\tT-2\nReuters\tT-2\n.\tO\n\n\"\tO\nWe\tO\nhave\tO\nalways\tO\nbeen\tO\nconcerned\tO\nabout\tO\nbarter\tO\ndeals\tO\nwith\tO\nother\tO\ncountries\tO\n,\tO\nviewing\tO\nthem\tO\nas\tO\na\tO\ndisguised\tO\nkind\tO\nof\tO\ncapital\tO\nflight\tO\nfrom\tO\nRussia\tT-1\n,\tO\n\"\tO\nMarina\tT-2\nVolkova\tT-2\n,\tO\ndeputy\tO\nhead\tO\nof\tO\nthe\tO\ncurrency\tO\ndepartment\tO\nat\tT-4\nthe\tT-4\nState\tB-ORG\nCustoms\tI-ORG\nCommittee\tI-ORG\n,\tO\ntold\tT-0\nReuters\tT-3\n.\tO\n\n\"\tO\nWe\tO\nhave\tO\nalways\tO\nbeen\tO\nconcerned\tO\nabout\tO\nbarter\tO\ndeals\tO\nwith\tO\nother\tO\ncountries\tO\n,\tO\nviewing\tO\nthem\tO\nas\tO\na\tO\ndisguised\tO\nkind\tO\nof\tO\ncapital\tO\nflight\tO\nfrom\tO\nRussia\tO\n,\tO\n\"\tO\nMarina\tT-0\nVolkova\tT-0\n,\tO\ndeputy\tT-1\nhead\tT-1\nof\tO\nthe\tO\ncurrency\tO\ndepartment\tO\nat\tO\nthe\tO\nState\tO\nCustoms\tO\nCommittee\tO\n,\tO\ntold\tO\nReuters\tB-ORG\n.\tO\n\nVolkova\tT-0\nsaid\tT-3\nlast\tO\nyear\tO\ngoods\tO\nhad\tO\nbeen\tO\nexported\tT-1\nunder\tO\nmany\tO\nRussian\tB-MISC\nbarter\tO\ndeals\tT-2\n,\tO\nwith\tO\nnothing\tO\nimported\tO\nin\tO\nreturn\tT-4\n.\tO\n\nBarter\tO\ndeals\tT-0\nwere\tO\nworth\tO\n$\tO\n4.9\tO\nbillion\tO\nlast\tO\nyear\tO\n,\tO\nor\tO\nabout\tO\neight\tO\npercent\tO\nof\tO\nall\tO\nRussian\tB-MISC\nexports\tT-3\nestimated\tT-1\nat\tO\n$\tO\n61.5\tO\nbillion\tO\n,\tO\nshe\tO\nsaid\tT-2\n.\tO\n\n\"\tO\nThe\tO\ncost\tO\nof\tO\nexported\tT-3\ngoods\tO\nis\tO\ntoo\tO\noften\tO\nunderstated\tT-0\n,\tO\nso\tO\nthe\tO\nactual\tO\nshare\tO\nof\tO\nbarter\tO\ndeals\tO\nin\tO\nRussian\tB-MISC\nexports\tO\nand\tO\nthe\tO\namount\tT-4\nof\tO\nunimported\tO\ngoods\tT-2\nmay\tO\nbe\tO\neven\tO\nhigher\tO\n,\tO\n\"\tO\nVolkova\tO\nsaid\tT-1\n.\tO\n\n\"\tO\nThe\tO\ncost\tO\nof\tO\nexported\tO\ngoods\tO\nis\tO\ntoo\tO\noften\tO\nunderstated\tO\n,\tO\nso\tO\nthe\tO\nactual\tO\nshare\tO\nof\tO\nbarter\tO\ndeals\tO\nin\tO\nRussian\tT-0\nexports\tO\nand\tO\nthe\tO\namount\tO\nof\tO\nunimported\tO\ngoods\tT-1\nmay\tO\nbe\tO\neven\tO\nhigher\tO\n,\tO\n\"\tO\nVolkova\tB-PER\nsaid\tO\n.\tO\n\nA\tO\nfew\tT-0\ndays\tO\nago\tO\nRussian\tB-MISC\nPresident\tT-1\nBoris\tT-1\nYeltsin\tT-1\nissued\tO\na\tO\ndecree\tO\non\tO\nstate\tO\nregulation\tO\nof\tO\nforeign\tO\nbarter\tO\ndeals\tO\n,\tO\nand\tO\nVolkova\tO\nsaid\tO\nthis\tO\n\"\tO\ncould\tO\nsubstantially\tO\nimprove\tO\nthe\tO\nsituation\tO\n\"\tO\n.\tO\n\nA\tO\nfew\tO\ndays\tO\nago\tO\nRussian\tO\nPresident\tO\nBoris\tB-PER\nYeltsin\tI-PER\nissued\tT-0\na\tO\ndecree\tO\non\tO\nstate\tO\nregulation\tO\nof\tO\nforeign\tO\nbarter\tT-1\ndeals\tO\n,\tO\nand\tO\nVolkova\tO\nsaid\tO\nthis\tO\n\"\tO\ncould\tO\nsubstantially\tO\nimprove\tO\nthe\tO\nsituation\tO\n\"\tO\n.\tO\n\nA\tO\nfew\tO\ndays\tO\nago\tO\nRussian\tT-0\nPresident\tT-0\nBoris\tT-0\nYeltsin\tT-0\nissued\tO\na\tO\ndecree\tO\non\tO\nstate\tO\nregulation\tO\nof\tO\nforeign\tO\nbarter\tO\ndeals\tO\n,\tO\nand\tO\nVolkova\tB-PER\nsaid\tT-1\nthis\tO\n\"\tO\ncould\tO\nsubstantially\tO\nimprove\tT-2\nthe\tO\nsituation\tO\n\"\tO\n.\tO\n\nIn\tO\nline\tO\nwith\tO\nthe\tO\ndecree\tT-0\n,\tO\nwhich\tO\nwill\tO\ncome\tO\ninto\tO\nforce\tO\non\tO\nNovember\tT-1\n1\tO\n,\tO\nall\tO\nRussian\tB-MISC\nbarter\tT-3\ntraders\tT-3\nwill\tO\nbe\tT-4\nobliged\tT-4\nto\tO\nimport\tO\ngoods\tT-2\nworth\tO\nthe\tO\ncost\tO\nof\tO\ntheir\tO\nexports\tO\nwithin\tO\n180\tO\ndays\tO\n.\tO\n\n\"\tO\nIf\tO\ntraders\tT-0\nare\tO\nlate\tO\n,\tO\nthey\tO\nwill\tO\nhave\tO\nto\tO\npay\tO\nfines\tT-1\nworth\tO\nthe\tO\ncost\tO\nof\tO\ntheir\tO\nexported\tO\ngoods\tO\n,\tO\n\"\tO\nVolkova\tB-PER\nsaid\tO\n.\tO\n\nUnderstating\tO\nthe\tO\ncost\tO\nof\tO\nexported\tO\ngoods\tO\ncould\tO\nstill\tO\nbe\tO\na\tO\nloophole\tT-0\nfor\tO\nbarter\tO\ndealers\tO\n,\tO\nbut\tO\nVolkova\tB-PER\nsaid\tT-1\nthe\tO\nauthorities\tO\nare\tO\ncurrently\tO\n\"\tO\ntackling\tO\nthe\tO\ntechnicalities\tO\nof\tO\nthe\tO\nissue\tO\n\"\tO\n.\tO\n\nBarter\tT-1\nhas\tO\nalways\tO\nbeen\tO\na\tO\nfeature\tO\nof\tO\nthe\tO\nSoviet\tB-LOC\nUnion\tI-LOC\n's\tT-0\nforeign\tT-0\ntrade\tT-0\n,\tO\nbut\tO\nYeltsin\tT-2\n's\tO\ndecrees\tO\nliberalising\tT-3\nforeign\tO\ntrade\tO\nin\tO\n1991-1992\tO\nhas\tO\ngiven\tO\nbarter\tO\na\tO\nnew\tO\nimpetus\tO\n.\tO\n\nBarter\tO\nhas\tO\nalways\tO\nbeen\tO\na\tO\nfeature\tO\nof\tO\nthe\tO\nSoviet\tO\nUnion\tO\n's\tO\nforeign\tO\ntrade\tO\n,\tO\nbut\tO\nYeltsin\tB-PER\n's\tO\ndecrees\tT-0\nliberalising\tO\nforeign\tO\ntrade\tO\nin\tO\n1991-1992\tO\nhas\tO\ngiven\tO\nbarter\tO\na\tO\nnew\tO\nimpetus\tO\n.\tO\n\nA\tO\nfew\tO\nyears\tO\nago\tO\n,\tO\nbarter\tO\ndeals\tO\naccounted\tO\nfor\tO\nup\tO\nto\tO\n25-30\tO\npercent\tO\nof\tO\nRussian\tB-MISC\nexports\tT-0\nbecause\tO\n\"\tO\nthousands\tO\n(\tO\nof\tO\n)\tO\ntrade\tO\ncompanies\tO\nwhich\tO\npopped\tO\nup\tO\npreferred\tO\nbarter\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nreliable\tO\nRussian\tO\nbanks\tO\nand\tO\nmoney\tO\ntransfer\tO\nsystems\tO\n\"\tO\n,\tO\nVolkova\tO\nsaid\tT-1\n.\tO\n\nA\tO\nfew\tO\nyears\tO\nago\tO\n,\tO\nbarter\tO\ndeals\tO\naccounted\tO\nfor\tO\nup\tO\nto\tO\n25-30\tO\npercent\tO\nof\tO\nRussian\tT-0\nexports\tO\nbecause\tO\n\"\tO\nthousands\tO\n(\tO\nof\tO\n)\tO\ntrade\tT-2\ncompanies\tT-2\nwhich\tO\npopped\tO\nup\tO\npreferred\tO\nbarter\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nreliable\tO\nRussian\tB-MISC\nbanks\tO\nand\tO\nmoney\tO\ntransfer\tT-1\nsystems\tO\n\"\tO\n,\tO\nVolkova\tO\nsaid\tO\n.\tO\n\nA\tO\nfew\tO\nyears\tO\nago\tO\n,\tO\nbarter\tO\ndeals\tO\naccounted\tT-2\nfor\tO\nup\tO\nto\tO\n25-30\tO\npercent\tO\nof\tO\nRussian\tT-0\nexports\tO\nbecause\tO\n\"\tO\nthousands\tO\n(\tO\nof\tO\n)\tO\ntrade\tO\ncompanies\tO\nwhich\tO\npopped\tO\nup\tO\npreferred\tO\nbarter\tO\nin\tO\nthe\tO\nabsence\tO\nof\tO\nreliable\tO\nRussian\tO\nbanks\tO\nand\tO\nmoney\tO\ntransfer\tO\nsystems\tO\n\"\tO\n,\tO\nVolkova\tB-PER\nsaid\tT-1\n.\tO\n\n\"\tO\nNow\tO\nmany\tO\nRussian\tB-MISC\nbanks\tO\nare\tO\nstrong\tT-2\nand\tO\ncan\tO\nmake\tO\nvarious\tO\nsorts\tO\nof\tO\nmoney\tT-0\ntranfers\tT-0\n,\tO\nwhile\tO\nincompetent\tT-3\ntraders\tO\nare\tO\nbeing\tO\nousted\tT-4\nby\tO\nmore\tO\nexperienced\tT-1\nones\tT-1\n.\tO\n\nBut\tO\nthe\tO\ncurrent\tO\nshare\tO\nof\tO\nbarter\tO\ndeals\tO\nin\tO\nRussian\tB-MISC\nexports\tO\nis\tO\nstill\tO\nhigh\tO\n,\tO\n\"\tO\nshe\tO\nsaid\tT-0\n.\tO\n\n--\tO\nDmitry\tB-PER\nSolovyov\tI-PER\n,\tO\nMoscow\tT-1\nNewsroom\tO\n,\tO\n+7095\tT-0\n941\tT-0\n8520\tT-0\n\n--\tO\nDmitry\tO\nSolovyov\tO\n,\tO\nMoscow\tB-ORG\nNewsroom\tI-ORG\n,\tO\n+7095\tT-0\n941\tT-0\n8520\tT-0\n\nViacom\tB-ORG\nplans\tT-0\n\"\tT-0\nMission\tT-0\n\"\tT-0\nsequel\tT-0\n-\tO\nreport\tO\n.\tO\n\nViacom\tO\nplans\tT-0\n\"\tO\nMission\tB-MISC\n\"\tO\nsequel\tT-1\n-\tT-1\nreport\tT-1\n.\tT-1\n\nParamount\tB-ORG\nPictures\tI-ORG\nis\tT-0\ngoing\tT-2\nahead\tO\nwith\tO\na\tO\nsequel\tT-1\nto\tO\nthe\tO\nTom\tO\nCruise\tO\nblockbuster\tO\n,\tO\n\"\tO\nMission\tO\n:\tO\nImpossible\tO\n\"\tO\nand\tO\nhopes\tO\nto\tO\nrelease\tO\nit\tO\nin\tO\nthe\tO\nsummer\tO\nof\tO\n1998\tO\n,\tO\nDaily\tO\nVariety\tO\nreported\tT-3\nin\tO\nits\tO\nFriday\tO\nedition\tO\n.\tO\n\nParamount\tO\nPictures\tO\nis\tT-3\ngoing\tT-3\nahead\tO\nwith\tO\na\tO\nsequel\tT-0\nto\tO\nthe\tT-2\nTom\tB-PER\nCruise\tI-PER\nblockbuster\tO\n,\tO\n\"\tO\nMission\tO\n:\tO\nImpossible\tO\n\"\tO\nand\tO\nhopes\tO\nto\tO\nrelease\tT-1\nit\tO\nin\tO\nthe\tO\nsummer\tO\nof\tO\n1998\tO\n,\tO\nDaily\tO\nVariety\tO\nreported\tO\nin\tO\nits\tO\nFriday\tO\nedition\tO\n.\tO\n\nParamount\tO\nPictures\tO\nis\tT-1\ngoing\tT-1\nahead\tT-1\nwith\tO\na\tO\nsequel\tO\nto\tO\nthe\tO\nTom\tO\nCruise\tO\nblockbuster\tO\n,\tO\n\"\tO\nMission\tB-MISC\n:\tI-MISC\nImpossible\tI-MISC\n\"\tO\nand\tO\nhopes\tT-2\nto\tO\nrelease\tT-3\nit\tO\nin\tO\nthe\tO\nsummer\tO\nof\tO\n1998\tO\n,\tO\nDaily\tO\nVariety\tO\nreported\tT-0\nin\tO\nits\tO\nFriday\tO\nedition\tO\n.\tO\n\nParamount\tO\nPictures\tO\nis\tO\ngoing\tO\nahead\tO\nwith\tO\na\tO\nsequel\tT-2\nto\tO\nthe\tO\nTom\tO\nCruise\tT-0\nblockbuster\tO\n,\tO\n\"\tO\nMission\tO\n:\tO\nImpossible\tO\n\"\tO\nand\tO\nhopes\tO\nto\tO\nrelease\tT-3\nit\tO\nin\tO\nthe\tO\nsummer\tO\nof\tO\n1998\tO\n,\tO\nDaily\tB-ORG\nVariety\tI-ORG\nreported\tT-1\nin\tO\nits\tO\nFriday\tO\nedition\tO\n.\tO\n\nIt\tO\n's\tO\nthe\tO\nbiggest\tO\nsuccess\tO\nfor\tO\nViacom\tB-MISC\nInc-owned\tI-MISC\nParamount\tT-1\nsince\tT-0\n1994\tO\n's\tO\n\"\tO\nForrest\tT-2\nGump\tT-2\n\"\tO\n.\tO\n\nIt\tO\n's\tO\nthe\tO\nbiggest\tO\nsuccess\tT-1\nfor\tO\nViacom\tT-0\nInc-owned\tT-0\nParamount\tB-ORG\nsince\tO\n1994\tO\n's\tO\n\"\tO\nForrest\tO\nGump\tO\n\"\tO\n.\tO\n\nIt\tO\n's\tO\nthe\tO\nbiggest\tO\nsuccess\tO\nfor\tT-1\nViacom\tT-0\nInc-owned\tO\nParamount\tT-2\nsince\tO\n1994\tO\n's\tO\n\"\tO\nForrest\tB-MISC\nGump\tI-MISC\n\"\tO\n.\tO\n\nCruise\tB-PER\nwill\tT-0\nreprise\tO\nhis\tO\nroles\tO\nas\tO\nstar\tT-2\nand\tO\nco-producer\tT-3\n,\tO\nand\tO\nwill\tO\nsoon\tO\nmeet\tO\nAcademy\tT-1\nAward-winning\tT-1\nscreenwriter\tO\nWilliam\tO\nGoldman\tO\n,\tO\nwho\tO\nwill\tO\nwrite\tO\nthe\tO\nscript\tO\n,\tO\nthe\tO\nreport\tO\nsaid\tO\n.\tO\n\nCruise\tT-0\nwill\tO\nreprise\tO\nhis\tO\nroles\tT-1\nas\tO\nstar\tO\nand\tO\nco-producer\tO\n,\tO\nand\tO\nwill\tO\nsoon\tO\nmeet\tO\nAcademy\tB-MISC\nAward-winning\tI-MISC\nscreenwriter\tT-3\nWilliam\tT-2\nGoldman\tT-2\n,\tO\nwho\tO\nwill\tO\nwrite\tO\nthe\tO\nscript\tO\n,\tO\nthe\tO\nreport\tO\nsaid\tO\n.\tO\n\nCruise\tO\nwill\tO\nreprise\tO\nhis\tO\nroles\tO\nas\tO\nstar\tO\nand\tO\nco-producer\tO\n,\tO\nand\tO\nwill\tO\nsoon\tO\nmeet\tT-0\nAcademy\tT-2\nAward-winning\tO\nscreenwriter\tT-3\nWilliam\tB-PER\nGoldman\tI-PER\n,\tO\nwho\tO\nwill\tO\nwrite\tT-1\nthe\tO\nscript\tT-4\n,\tO\nthe\tO\nreport\tO\nsaid\tT-5\n.\tT-2\n\nIt\tO\nsaid\tO\n\"\tO\nMission\tB-MISC\n:\tI-MISC\nImpossible\tI-MISC\n\"\tO\ndirector\tT-1\nBrian\tO\nDe\tO\nPalma\tO\nwould\tO\nhave\tO\nfirst\tO\ncrack\tO\nat\tO\nthe\tO\nsequel\tT-0\n,\tO\nthough\tO\nno\tO\ndeals\tO\nhave\tO\nbeen\tO\nmade\tO\nyet\tO\n.\tO\n\nIt\tO\nsaid\tO\n\"\tO\nMission\tO\n:\tO\nImpossible\tO\n\"\tO\ndirector\tT-1\nBrian\tB-PER\nDe\tI-PER\nPalma\tI-PER\nwould\tT-0\nhave\tT-0\nfirst\tO\ncrack\tO\nat\tO\nthe\tO\nsequel\tO\n,\tO\nthough\tO\nno\tO\ndeals\tO\nhave\tO\nbeen\tO\nmade\tO\nyet\tO\n.\tO\n\nGoldman\tB-PER\n,\tO\nwhose\tT-5\nOscars\tT-2\nwere\tO\nfor\tO\n\"\tO\nButch\tT-3\nCassidy\tT-3\nand\tO\nthe\tO\nSundance\tT-4\nKid\tT-4\n\"\tO\nand\tO\n\"\tO\nAll\tO\nthe\tO\nPresident\tT-0\n's\tT-0\nMen\tT-0\n\"\tO\n,\tO\nearlier\tO\nthis\tO\nsummer\tO\ncriticised\tO\nsome\tO\nof\tO\nthe\tO\nseason\tO\n's\tO\nblockbusters\tT-1\n.\tO\n\nGoldman\tO\n,\tO\nwhose\tO\nOscars\tB-MISC\nwere\tO\nfor\tO\n\"\tO\nButch\tT-0\nCassidy\tO\nand\tO\nthe\tO\nSundance\tO\nKid\tO\n\"\tO\nand\tO\n\"\tO\nAll\tO\nthe\tO\nPresident\tO\n's\tO\nMen\tO\n\"\tO\n,\tO\nearlier\tO\nthis\tO\nsummer\tO\ncriticised\tO\nsome\tO\nof\tO\nthe\tO\nseason\tO\n's\tO\nblockbusters\tO\n.\tO\n\nGoldman\tO\n,\tO\nwhose\tO\nOscars\tT-1\nwere\tT-0\nfor\tO\n\"\tO\nButch\tB-MISC\nCassidy\tI-MISC\nand\tI-MISC\nthe\tI-MISC\nSundance\tI-MISC\nKid\tI-MISC\n\"\tO\nand\tT-2\n\"\tO\nAll\tO\nthe\tO\nPresident\tO\n's\tO\nMen\tO\n\"\tO\n,\tO\nearlier\tO\nthis\tO\nsummer\tO\ncriticised\tO\nsome\tO\nof\tO\nthe\tO\nseason\tO\n's\tO\nblockbusters\tO\n.\tO\n\nGoldman\tO\n,\tO\nwhose\tO\nOscars\tT-1\nwere\tO\nfor\tO\n\"\tO\nButch\tO\nCassidy\tO\nand\tO\nthe\tO\nSundance\tO\nKid\tO\n\"\tO\nand\tT-0\n\"\tO\nAll\tB-MISC\nthe\tI-MISC\nPresident\tI-MISC\n's\tI-MISC\nMen\tI-MISC\n\"\tO\n,\tO\nearlier\tO\nthis\tO\nsummer\tO\ncriticised\tT-2\nsome\tO\nof\tO\nthe\tO\nseason\tO\n's\tO\nblockbusters\tO\n.\tO\n\nHowever\tO\n,\tO\nhe\tO\nsingled\tT-2\nout\tO\n\"\tO\nMission\tB-MISC\n:\tI-MISC\nImpossible\tI-MISC\n\"\tO\nas\tT-0\nan\tT-0\nespecially\tT-0\nentertaining\tT-0\nmovie\tT-0\n,\tO\nDaily\tO\nVariety\tO\nsaid\tT-1\n.\tO\n\nHowever\tO\n,\tO\nhe\tO\nsingled\tT-1\nout\tT-1\n\"\tO\nMission\tO\n:\tO\nImpossible\tO\n\"\tO\nas\tO\nan\tO\nespecially\tO\nentertaining\tO\nmovie\tO\n,\tO\nDaily\tB-ORG\nVariety\tI-ORG\nsaid\tT-0\n.\tO\n\nCRICKET\tO\n-\tO\nCRAWLEY\tB-PER\nFORCED\tT-1\nTO\tO\nSIT\tT-0\nAND\tO\nWAIT\tO\n.\tO\n\nEngland\tB-LOC\nbatsman\tO\nJohn\tO\nCrawley\tO\nwas\tO\nforced\tT-0\nto\tO\nendure\tO\na\tO\nfrustrating\tO\ndelay\tO\nof\tO\nover\tO\nthree\tO\nhours\tO\nbefore\tO\nresuming\tO\nhis\tO\nquest\tO\nfor\tO\na\tO\nmaiden\tO\ntest\tO\ncentury\tO\nin\tO\nthe\tO\nthird\tO\ntest\tO\nagainst\tO\nPakistan\tO\non\tO\nFriday\tO\n.\tO\n\nEngland\tO\nbatsman\tT-1\nJohn\tB-PER\nCrawley\tI-PER\nwas\tT-0\nforced\tO\nto\tO\nendure\tO\na\tO\nfrustrating\tO\ndelay\tT-2\nof\tO\nover\tO\nthree\tO\nhours\tO\nbefore\tO\nresuming\tO\nhis\tO\nquest\tO\nfor\tO\na\tO\nmaiden\tO\ntest\tO\ncentury\tO\nin\tO\nthe\tO\nthird\tO\ntest\tO\nagainst\tO\nPakistan\tO\non\tO\nFriday\tO\n.\tO\n\nEngland\tO\nbatsman\tT-1\nJohn\tO\nCrawley\tO\nwas\tO\nforced\tO\nto\tO\nendure\tO\na\tO\nfrustrating\tO\ndelay\tO\nof\tO\nover\tO\nthree\tO\nhours\tO\nbefore\tO\nresuming\tO\nhis\tO\nquest\tO\nfor\tO\na\tO\nmaiden\tO\ntest\tO\ncentury\tO\nin\tO\nthe\tO\nthird\tO\ntest\tO\nagainst\tT-0\nPakistan\tB-LOC\non\tO\nFriday\tT-2\n.\tO\n\nHeavy\tO\novernight\tO\nrain\tO\nand\tO\nmorning\tO\ndrizzle\tO\nruled\tO\nout\tO\nany\tO\nplay\tO\nbefore\tO\nlunch\tO\non\tO\nthe\tO\nsecond\tO\nday\tO\nbut\tO\nan\tO\nimprovement\tO\nin\tO\nthe\tO\nweather\tO\nprompted\tO\nthe\tO\numpires\tT-1\nto\tO\nannounce\tO\na\tO\n1415\tO\nlocal\tT-0\ntime\tO\n(\tO\n1315\tO\nGMT\tB-MISC\n)\tO\nstart\tO\nin\tO\nthe\tO\nevent\tO\nof\tO\nno\tO\nfurther\tO\nrain\tO\n.\tO\n\nCrawley\tB-PER\n,\tO\nunbeaten\tT-0\non\tO\n94\tO\novernight\tO\nin\tO\nan\tO\nEngland\tO\ntotal\tO\nof\tO\n278\tO\nfor\tO\nsix\tO\n,\tO\nwas\tT-2\nspotted\tT-2\nstrumming\tT-1\na\tO\nguitar\tO\nin\tO\nthe\tO\ndressing-room\tO\nas\tO\nthe\tO\nOval\tO\nground\tO\nstaff\tO\ntook\tO\ncentre\tO\nstage\tO\n.\tT-0\n\nCrawley\tT-0\n,\tO\nunbeaten\tT-2\non\tO\n94\tO\novernight\tO\nin\tO\nan\tO\nEngland\tB-LOC\ntotal\tO\nof\tO\n278\tO\nfor\tO\nsix\tO\n,\tO\nwas\tO\nspotted\tO\nstrumming\tO\na\tO\nguitar\tO\nin\tO\nthe\tO\ndressing-room\tT-1\nas\tO\nthe\tO\nOval\tO\nground\tO\nstaff\tO\ntook\tO\ncentre\tO\nstage\tO\n.\tO\n\nCrawley\tO\n,\tO\nunbeaten\tO\non\tO\n94\tO\novernight\tO\nin\tO\nan\tO\nEngland\tO\ntotal\tO\nof\tO\n278\tO\nfor\tO\nsix\tO\n,\tO\nwas\tO\nspotted\tT-0\nstrumming\tO\na\tO\nguitar\tO\nin\tO\nthe\tO\ndressing-room\tO\nas\tO\nthe\tO\nOval\tB-LOC\nground\tO\nstaff\tO\ntook\tO\ncentre\tO\nstage\tO\n.\tO\n\nThere\tO\nwere\tO\nseveral\tO\ndamp\tO\npatches\tO\non\tO\nthe\tO\nsquare\tO\nand\tO\nthe\tO\noutfield\tO\nand\tO\nit\tO\nwas\tO\nstill\tO\nraining\tO\nwhen\tO\nthe\tO\nplayers\tT-0\ntook\tO\nan\tO\nearly\tO\nlunch\tO\nat\tO\n1230\tO\nlocal\tO\ntime\tO\n(\tO\n1130\tO\nGMT\tB-MISC\n)\tO\n.\tO\n\nWhen\tO\nbrighter\tO\nweather\tO\nfinally\tO\narrived\tO\n,\tO\nthe\tO\numpires\tO\nannounced\tO\na\tO\nrevised\tO\nfigure\tO\nof\tO\n67\tO\novers\tO\nto\tO\nbe\tO\nbowled\tT-0\nwith\tO\nplay\tO\nextended\tO\nto\tO\nat\tO\nleast\tO\n1900\tO\nlocal\tO\ntime\tO\n(\tO\n1800\tO\nGMT\tB-MISC\n)\tO\n.\tO\n\nMOTOR\tT-2\nRACING\tT-2\n-\tO\nBELGIAN\tB-MISC\nGRAND\tT-0\nPRIX\tT-0\nPRACTICE\tT-1\nTIMES\tO\n.\tO\n\nMOTOR\tT-0\nRACING\tT-0\n-\tO\nBELGIAN\tT-1\nGRAND\tB-MISC\nPRIX\tI-MISC\nPRACTICE\tT-2\nTIMES\tO\n.\tO\n\nSPA-FRANCORCHAMPS\tB-LOC\n,\tO\nBelgium\tT-0\n1996-08-23\tO\n\nSPA-FRANCORCHAMPS\tT-0\n,\tO\nBelgium\tB-LOC\n1996-08-23\tO\n\nBelgian\tT-0\nGrand\tB-MISC\nPrix\tI-MISC\nmotor\tO\nrace\tO\n:\tO\n\n1.\tO\nGerhard\tB-PER\nBerger\tI-PER\n(\tO\nAustria\tT-0\n)\tO\nBenetton\tO\n1\tO\nminute\tO\n53.706\tO\nseconds\tO\n\n1.\tO\nGerhard\tO\nBerger\tO\n(\tO\nAustria\tB-LOC\n)\tO\nBenetton\tT-0\n1\tO\nminute\tO\n53.706\tO\nseconds\tO\n\n1.\tO\nGerhard\tT-1\nBerger\tT-1\n(\tO\nAustria\tT-0\n)\tO\nBenetton\tB-ORG\n1\tO\nminute\tO\n53.706\tO\nseconds\tO\n\n2.\tO\nDavid\tB-PER\nCoulthard\tI-PER\n(\tO\nBritain\tO\n)\tO\nMcLaren\tT-0\n1:54.342\tO\n\n2.\tO\nDavid\tO\nCoulthard\tO\n(\tO\nBritain\tT-0\n)\tO\nMcLaren\tB-ORG\n1:54.342\tO\n\n3.\tO\nJacques\tB-PER\nVilleneuve\tI-PER\n(\tO\nCanada\tO\n)\tO\nWilliams\tT-0\n1:54.443\tT-1\n\n4.\tO\nMika\tT-0\nHakkinen\tT-0\n(\tO\nFinland\tB-LOC\n)\tO\nMcLaren\tO\n1:54.754\tO\n\n5.\tO\nHeinz-Harald\tB-PER\nFrentzen\tI-PER\n(\tO\nGermany\tT-0\n)\tO\n1:54.984\tO\n\n6.\tO\nJean\tB-PER\nAlesi\tI-PER\n(\tT-0\nFrance\tT-0\n)\tT-0\nBenetton\tT-1\n1:55.101\tO\n\n6.\tO\nJean\tT-0\nAlesi\tT-0\n(\tO\nFrance\tB-LOC\n)\tO\nBenetton\tT-1\n1:55.101\tO\n\n6.\tO\nJean\tT-0\nAlesi\tT-0\n(\tO\nFrance\tO\n)\tO\nBenetton\tB-ORG\n1:55.101\tT-1\n\n7.\tO\nDamon\tB-PER\nHill\tI-PER\n(\tO\nBritain\tO\n)\tO\nWilliams\tO\n1:55.281\tT-0\n\n7.\tO\nDamon\tT-0\nHill\tT-0\n(\tO\nBritain\tB-LOC\n)\tO\nWilliams\tT-1\n1:55.281\tO\n\n7.\tO\nDamon\tO\nHill\tO\n(\tO\nBritain\tT-1\n)\tO\nWilliams\tB-ORG\n1:55.281\tT-0\n\n8.\tO\nMichael\tB-PER\nSchumacher\tI-PER\n(\tO\nGermany\tT-0\n)\tO\n1:55.333\tO\n\n9.\tO\nMartin\tB-PER\nBrundle\tI-PER\n(\tO\nBritain\tT-1\n)\tO\nJordan\tT-0\n1:55.385\tT-2\n\n9.\tO\nMartin\tT-0\nBrundle\tT-0\n(\tO\nBritain\tB-LOC\n)\tO\nJordan\tO\n1:55.385\tO\n\n9.\tO\nMartin\tT-0\nBrundle\tT-0\n(\tT-0\nBritain\tT-0\n)\tT-0\nJordan\tB-ORG\n1:55.385\tO\n\n10.\tO\nRubens\tB-PER\nBarrichello\tI-PER\n(\tO\nBrazil\tO\n)\tO\nJordan\tT-0\n1:55.645\tO\n\n10.\tO\nRubens\tO\nBarrichello\tO\n(\tO\nBrazil\tB-LOC\n)\tO\nJordan\tT-0\n1:55.645\tO\n\n10.\tO\nRubens\tO\nBarrichello\tO\n(\tO\nBrazil\tT-0\n)\tO\nJordan\tB-ORG\n1:55.645\tO\n\n11.\tO\nJohnny\tB-PER\nHerbert\tI-PER\n(\tO\nBritain\tT-0\n)\tO\nSauber\tO\n1:56.318\tO\n\n11.\tO\nJohnny\tO\nHerbert\tT-0\n(\tO\nBritain\tB-LOC\n)\tO\nSauber\tO\n1:56.318\tT-0\n\n11.\tO\nJohnny\tT-0\nHerbert\tT-0\n(\tO\nBritain\tO\n)\tO\nSauber\tB-ORG\n1:56.318\tO\n\n12.\tO\nOlivier\tB-PER\nPanis\tI-PER\n(\tO\nFrance\tT-0\n)\tO\nLigier\tT-1\n1:56.417\tO\n\n12.\tO\nOlivier\tT-1\nPanis\tO\n(\tO\nFrance\tB-LOC\n)\tO\nLigier\tT-0\n1:56.417\tO\n\n12.\tO\nOlivier\tO\nPanis\tO\n(\tO\nFrance\tT-0\n)\tO\nLigier\tB-ORG\n1:56.417\tO\n\nTENNIS\tT-0\n-\tO\nRESULTS\tO\nAT\tO\nTOSHIBA\tB-MISC\nCLASSIC\tI-MISC\n.\tO\n\n$\tO\n450,000\tO\nToshiba\tB-MISC\nClassic\tI-MISC\ntennis\tT-2\ntournament\tT-2\non\tO\nThursday\tT-1\n(\tO\nprefix\tO\n\n2\tO\n-\tO\nConchita\tB-PER\nMartinez\tI-PER\n(\tO\nSpain\tO\n)\tO\nbeat\tT-1\nNathalie\tT-0\nTauziat\tO\n(\tO\nFrance\tO\n)\tO\n\n2\tO\n-\tO\nConchita\tO\nMartinez\tO\n(\tO\nSpain\tB-LOC\n)\tO\nbeat\tT-1\nNathalie\tT-0\nTauziat\tO\n(\tO\nFrance\tO\n)\tO\n\n2\tO\n-\tO\nConchita\tT-0\nMartinez\tT-0\n(\tO\nSpain\tO\n)\tO\nbeat\tT-1\nNathalie\tB-PER\nTauziat\tI-PER\n(\tO\nFrance\tT-2\n)\tO\n\n2\tO\n-\tO\nConchita\tO\nMartinez\tO\n(\tO\nSpain\tO\n)\tO\nbeat\tT-1\nNathalie\tT-0\nTauziat\tT-0\n(\tO\nFrance\tB-LOC\n)\tO\n\n5\tO\n-\tO\nGabriela\tB-PER\nSabatini\tI-PER\n(\tO\nArgentina\tO\n)\tO\nbeat\tT-1\nAsa\tT-0\nCarlsson\tT-0\n(\tO\nSweden\tO\n)\tO\n\n5\tO\n-\tO\nGabriela\tO\nSabatini\tO\n(\tO\nArgentina\tB-LOC\n)\tO\nbeat\tT-0\nAsa\tO\nCarlsson\tO\n(\tO\nSweden\tO\n)\tO\n\n5\tO\n-\tO\nGabriela\tO\nSabatini\tO\n(\tO\nArgentina\tO\n)\tO\nbeat\tT-1\nAsa\tB-PER\nCarlsson\tI-PER\n(\tO\nSweden\tT-0\n)\tO\n\n5\tO\n-\tO\nGabriela\tT-1\nSabatini\tT-1\n(\tO\nArgentina\tO\n)\tO\nbeat\tT-3\nAsa\tT-2\nCarlsson\tT-2\n(\tO\nSweden\tB-LOC\n)\tO\n\nKatarina\tB-PER\nStudenikova\tI-PER\n(\tO\nSlovakia\tO\n)\tO\nbeat\tT-0\n6\tO\n-\tO\nKarina\tO\nHabsudova\tO\n\nKatarina\tT-1\nStudenikova\tT-1\n(\tO\nSlovakia\tB-LOC\n)\tO\nbeat\tT-0\n6\tO\n-\tO\nKarina\tO\nHabsudova\tO\n\nKatarina\tO\nStudenikova\tO\n(\tO\nSlovakia\tO\n)\tO\nbeat\tT-1\n6\tO\n-\tO\nKarina\tB-PER\nHabsudova\tI-PER\n\n(\tO\nSlovakia\tB-LOC\n)\tO\n7-6\tT-0\n(\tO\n7-4\tT-1\n)\tO\n6-2\tT-2\n\n(\tO\nCorrects\tO\nthat\tO\nHabsudova\tB-PER\nis\tO\nsixth\tO\nseed\tT-0\n)\tO\n.\tO\n\nSOCCER\tT-2\n-\tO\nENGLISH\tB-MISC\nFIRST\tO\nDIVISION\tT-0\nRESULTS\tT-1\n.\tO\n\nResults\tT-0\nof\tO\nEnglish\tB-MISC\nfirst\tO\ndivision\tO\n\nPortsmouth\tB-ORG\n1\tO\nQueens\tT-0\nPark\tT-0\nRangers\tT-0\n2\tO\n\nPortsmouth\tO\n1\tO\nQueens\tB-ORG\nPark\tI-ORG\nRangers\tI-ORG\n2\tT-0\n\nSOCCER\tT-0\n-\tO\nSCOTTISH\tB-MISC\nTHIRD\tT-2\nDIVISION\tO\nRESULT\tT-1\n.\tO\n\nResult\tT-0\nof\tO\na\tO\nScottish\tB-MISC\nthird\tO\n\nEast\tB-ORG\nStirling\tI-ORG\n0\tO\nAlbion\tO\n1\tT-0\n\nEast\tT-1\nStirling\tT-1\n0\tO\nAlbion\tB-ORG\n1\tT-0\n\nCRICKET\tT-0\n-\tO\nENGLISH\tB-MISC\nCOUNTY\tI-MISC\nCHAMPIONSHIP\tI-MISC\nSCORES\tT-1\n.\tO\n\nEnglish\tB-MISC\nCounty\tI-MISC\nChampionship\tI-MISC\ncricket\tT-0\nmatches\tO\non\tO\nFriday\tO\n:\tO\n\nAt\tO\nWeston-super-Mare\tB-LOC\n:\tO\nDurham\tT-0\n326\tO\n(\tO\nD.\tO\nCox\tO\n95\tO\nnot\tO\nout\tO\n,\tO\n\nAt\tO\nWeston-super-Mare\tO\n:\tO\nDurham\tT-1\n326\tO\n(\tO\nD.\tB-PER\nCox\tI-PER\n95\tO\nnot\tT-0\nout\tT-0\n,\tO\n\nS.\tB-PER\nCampbell\tI-PER\n69\tO\n;\tO\nG.\tT-0\nRose\tT-1\n7-73\tO\n)\tO\n.\tO\n\nS.\tT-0\nCampbell\tO\n69\tO\n;\tO\nG.\tB-PER\nRose\tI-PER\n7-73\tO\n)\tO\n.\tT-0\n\nSomerset\tB-ORG\n298-6\tT-0\n(\tO\nM.\tO\nLathwell\tO\n85\tO\n,\tO\n\nSomerset\tT-0\n298-6\tO\n(\tO\nM.\tB-PER\nLathwell\tI-PER\n85\tO\n,\tO\n\nR.\tB-PER\nHarden\tI-PER\n65\tT-0\n)\tO\n.\tO\n\nAt\tT-0\nColchester\tB-LOC\n:\tO\nGloucestershire\tT-1\n280\tO\n(\tO\nJ.\tO\nRussell\tO\n63\tO\n,\tO\nA.\tO\nSymonds\tO\n\nAt\tT-0\nColchester\tT-1\n:\tO\nGloucestershire\tB-ORG\n280\tO\n(\tO\nJ.\tO\nRussell\tO\n63\tO\n,\tO\nA.\tO\nSymonds\tO\n\nAt\tO\nColchester\tO\n:\tO\nGloucestershire\tT-0\n280\tO\n(\tO\nJ.\tB-PER\nRussell\tI-PER\n63\tO\n,\tO\nA.\tO\nSymonds\tO\n\nAt\tO\nColchester\tO\n:\tO\nGloucestershire\tT-0\n280\tO\n(\tO\nJ.\tT-1\nRussell\tT-1\n63\tT-1\n,\tO\nA.\tB-PER\nSymonds\tI-PER\n\nEssex\tB-ORG\n194-0\tO\n(\tO\nG.\tO\nGooch\tO\n105\tO\nnot\tO\nout\tO\n,\tO\nD.\tO\nRobinson\tT-0\n\nEssex\tT-2\n194-0\tT-0\n(\tO\nG.\tB-PER\nGooch\tI-PER\n105\tO\nnot\tT-1\nout\tT-1\n,\tO\nD.\tO\nRobinson\tO\n\nEssex\tO\n194-0\tO\n(\tO\nG.\tO\nGooch\tO\n105\tO\nnot\tT-0\nout\tT-0\n,\tO\nD.\tB-PER\nRobinson\tI-PER\n\nAt\tT-0\nCardiff\tB-LOC\n:\tO\nKent\tT-1\n255-3\tO\n(\tO\nD.\tO\nFulton\tT-2\n64\tO\n,\tO\nM.\tO\nWalker\tT-3\n59\tO\n,\tO\nC.\tO\nHooper\tT-4\n\nAt\tT-4\nCardiff\tT-4\n:\tO\nKent\tB-ORG\n255-3\tT-0\n(\tO\nD.\tO\nFulton\tO\n64\tT-1\n,\tO\nM.\tO\nWalker\tO\n59\tT-2\n,\tO\nC.\tO\nHooper\tT-3\n\nAt\tO\nCardiff\tO\n:\tO\nKent\tO\n255-3\tT-2\n(\tO\nD.\tB-PER\nFulton\tI-PER\n64\tT-3\n,\tO\nM.\tT-0\nWalker\tT-0\n59\tT-4\n,\tO\nC.\tT-1\nHooper\tT-1\n\nAt\tO\nCardiff\tO\n:\tO\nKent\tT-0\n255-3\tO\n(\tO\nD.\tT-1\nFulton\tT-1\n64\tO\n,\tO\nM.\tB-PER\nWalker\tI-PER\n59\tO\n,\tO\nC.\tT-2\nHooper\tT-2\n\nAt\tO\nCardiff\tT-0\n:\tO\nKent\tO\n255-3\tO\n(\tO\nD.\tO\nFulton\tO\n64\tO\n,\tO\nM.\tO\nWalker\tO\n59\tO\n,\tO\nC.\tB-PER\nHooper\tI-PER\n\n52\tO\nnot\tT-0\nout\tT-0\n)\tO\nv\tO\nGlamorgan\tB-ORG\n.\tO\n\nAt\tT-0\nLeicester\tB-LOC\n:\tO\nLeicestershire\tO\n343-8\tO\n(\tO\nP.\tO\nSimmons\tO\n108\tO\n,\tO\nP.\tO\nNixon\tO\n\nAt\tO\nLeicester\tO\n:\tO\nLeicestershire\tB-ORG\n343-8\tO\n(\tO\nP.\tT-0\nSimmons\tT-0\n108\tO\n,\tO\nP.\tT-1\nNixon\tT-1\n\nAt\tT-2\nLeicester\tO\n:\tO\nLeicestershire\tT-0\n343-8\tO\n(\tO\nP.\tT-1\nSimmons\tT-1\n108\tO\n,\tO\nP.\tB-PER\nNixon\tI-PER\n\nAt\tT-0\nNorthampton\tB-LOC\n:\tO\nSussex\tT-1\n389\tO\n(\tO\nN.\tT-2\nLenham\tT-2\n145\tO\n,\tO\nV.\tT-3\nDrakes\tT-3\n59\tO\n,\tO\n\nAt\tO\nNorthampton\tT-0\n:\tO\nSussex\tB-ORG\n389\tO\n(\tO\nN.\tO\nLenham\tO\n145\tO\n,\tO\nV.\tO\nDrakes\tO\n59\tO\n,\tO\n\nAt\tO\nNorthampton\tO\n:\tO\nSussex\tT-0\n389\tO\n(\tO\nN.\tB-PER\nLenham\tI-PER\n145\tO\n,\tO\nV.\tT-2\nDrakes\tT-2\n59\tO\n,\tO\n\nAt\tO\nNorthampton\tO\n:\tO\nSussex\tT-2\n389\tT-0\n(\tO\nN.\tO\nLenham\tO\n145\tT-1\n,\tO\nV.\tB-PER\nDrakes\tI-PER\n59\tT-3\n,\tO\n\nA.\tB-PER\nWells\tI-PER\n51\tO\n;\tO\nA.\tO\nPenberthy\tT-0\n4-36\tO\n)\tO\n.\tO\n\nA.\tT-0\nWells\tT-0\n51\tO\n;\tO\nA.\tB-PER\nPenberthy\tI-PER\n4-36\tO\n)\tO\n.\tO\n\nNorthamptonshire\tB-ORG\n160-4\tT-0\n(\tO\nK.\tO\nCurran\tO\n\nAt\tT-0\nTrent\tB-LOC\nBridge\tI-LOC\n:\tO\nNottinghamshire\tO\n392-6\tO\n(\tO\nG.\tO\nArcher\tO\n143\tO\nnot\tO\n\nAt\tT-0\nTrent\tO\nBridge\tO\n:\tO\nNottinghamshire\tB-ORG\n392-6\tO\n(\tO\nG.\tO\nArcher\tO\n143\tO\nnot\tO\n\nAt\tO\nTrent\tT-0\nBridge\tT-0\n:\tO\nNottinghamshire\tO\n392-6\tO\n(\tO\nG.\tB-PER\nArcher\tI-PER\n143\tO\nnot\tO\n\nout\tO\n,\tO\nM.\tB-PER\nDowman\tI-PER\n107\tO\n)\tO\nv\tT-0\nSurrey\tO\n.\tO\n\nout\tO\n,\tO\nM.\tO\nDowman\tO\n107\tO\n)\tO\nv\tT-0\nSurrey\tB-ORG\n.\tO\n\nAt\tO\nWorcester\tB-LOC\n:\tO\nWarwickshire\tT-0\n310\tO\n(\tO\nA.\tO\nGiles\tO\n83\tO\n,\tO\nT.\tO\nMunton\tO\n54\tO\nnot\tO\n\nAt\tO\nWorcester\tO\n:\tO\nWarwickshire\tB-ORG\n310\tT-0\n(\tO\nA.\tO\nGiles\tO\n83\tT-1\n,\tO\nT.\tO\nMunton\tO\n54\tT-2\nnot\tO\n\nAt\tO\nWorcester\tT-1\n:\tO\nWarwickshire\tO\n310\tO\n(\tO\nA.\tB-PER\nGiles\tI-PER\n83\tT-0\n,\tT-0\nT.\tT-0\nMunton\tT-0\n54\tT-0\nnot\tT-0\n\nAt\tO\nWorcester\tT-0\n:\tO\nWarwickshire\tO\n310\tO\n(\tO\nA.\tO\nGiles\tO\n83\tO\n,\tO\nT.\tB-PER\nMunton\tI-PER\n54\tO\nnot\tO\n\nout\tO\n,\tO\nW.\tB-PER\nKhan\tI-PER\n52\tO\n;\tO\nR.\tO\nIllingworth\tO\n4-54\tT-0\n,\tO\nS.\tO\nLampitt\tO\n4-90\tT-1\n)\tO\n.\tO\n\nout\tO\n,\tO\nW.\tO\nKhan\tO\n52\tO\n;\tO\nR.\tB-PER\nIllingworth\tI-PER\n4-54\tT-0\n,\tO\nS.\tO\nLampitt\tT-1\n4-90\tO\n)\tO\n.\tO\n\nAt\tT-0\nHeadingley\tT-1\n:\tO\nYorkshire\tB-ORG\n529-8\tO\ndeclared\tO\n(\tO\nC.\tT-2\nWhite\tT-2\n181\tO\n,\tO\n\nAt\tO\nHeadingley\tO\n:\tO\nYorkshire\tT-1\n529-8\tO\ndeclared\tT-0\n(\tO\nC.\tB-PER\nWhite\tI-PER\n181\tO\n,\tO\n\nR.\tB-PER\nBlakey\tI-PER\n109\tO\nnot\tT-0\nout\tT-0\n,\tO\nM.\tO\nMoxon\tO\n66\tO\n,\tO\nM.\tO\nVaughan\tO\n57\tO\n)\tO\n.\tO\n\nR.\tT-1\nBlakey\tT-1\n109\tO\nnot\tO\nout\tT-0\n,\tO\nM.\tB-PER\nMoxon\tI-PER\n66\tO\n,\tO\nM.\tO\nVaughan\tO\n57\tO\n)\tO\n.\tO\n\nR.\tT-0\nBlakey\tT-0\n109\tO\nnot\tO\nout\tO\n,\tO\nM.\tT-1\nMoxon\tT-1\n66\tO\n,\tO\nM.\tB-PER\nVaughan\tI-PER\n57\tO\n)\tO\n.\tO\n\n162-4\tT-0\n(\tO\nN.\tB-PER\nFairbrother\tI-PER\n53\tO\nnot\tO\nout\tO\n)\tO\n.\tO\n\nCRICKET\tO\n-\tO\nPOLLOCK\tB-PER\nHOPES\tT-1\nFOR\tO\nRETURN\tO\nTO\tO\nWARWICKSHIRE\tT-0\n.\tO\n\nCRICKET\tT-2\n-\tO\nPOLLOCK\tT-1\nHOPES\tT-0\nFOR\tO\nRETURN\tT-3\nTO\tO\nWARWICKSHIRE\tB-ORG\n.\tO\n\nSouth\tB-MISC\nAfrican\tI-MISC\nall-rounder\tT-0\nShaun\tT-1\nPollock\tO\n,\tO\nforced\tO\nto\tO\ncut\tO\nshort\tO\nhis\tO\nfirst\tO\nseason\tO\nwith\tO\nWarwickshire\tO\nto\tO\nhave\tO\nankle\tO\nsurgery\tO\n,\tO\nhas\tO\ntold\tO\nthe\tO\nEnglish\tO\ncounty\tO\nhe\tO\nwould\tO\nlike\tO\nto\tO\nreturn\tO\nlater\tO\nin\tO\nhis\tO\ncareer\tO\n.\tT-1\n\nSouth\tO\nAfrican\tO\nall-rounder\tO\nShaun\tB-PER\nPollock\tI-PER\n,\tO\nforced\tO\nto\tO\ncut\tO\nshort\tO\nhis\tO\nfirst\tO\nseason\tO\nwith\tO\nWarwickshire\tT-0\nto\tO\nhave\tO\nankle\tO\nsurgery\tO\n,\tO\nhas\tO\ntold\tO\nthe\tO\nEnglish\tO\ncounty\tO\nhe\tO\nwould\tO\nlike\tO\nto\tO\nreturn\tO\nlater\tO\nin\tO\nhis\tO\ncareer\tO\n.\tO\n\nSouth\tO\nAfrican\tO\nall-rounder\tO\nShaun\tT-3\nPollock\tT-3\n,\tO\nforced\tO\nto\tO\ncut\tT-0\nshort\tO\nhis\tO\nfirst\tO\nseason\tT-4\nwith\tO\nWarwickshire\tB-ORG\nto\tO\nhave\tO\nankle\tO\nsurgery\tO\n,\tO\nhas\tO\ntold\tT-1\nthe\tO\nEnglish\tO\ncounty\tO\nhe\tO\nwould\tO\nlike\tO\nto\tO\nreturn\tT-2\nlater\tO\nin\tO\nhis\tO\ncareer\tO\n.\tO\n\nSouth\tO\nAfrican\tO\nall-rounder\tO\nShaun\tO\nPollock\tO\n,\tO\nforced\tT-1\nto\tO\ncut\tO\nshort\tO\nhis\tO\nfirst\tO\nseason\tO\nwith\tO\nWarwickshire\tO\nto\tO\nhave\tO\nankle\tO\nsurgery\tO\n,\tO\nhas\tO\ntold\tO\nthe\tO\nEnglish\tB-MISC\ncounty\tT-0\nhe\tO\nwould\tO\nlike\tO\nto\tO\nreturn\tO\nlater\tO\nin\tO\nhis\tO\ncareer\tO\n.\tO\n\nPollock\tB-PER\n,\tO\nwho\tT-0\nreturns\tT-1\nhome\tT-1\na\tO\nmonth\tO\nearly\tO\nnext\tO\nweek\tO\n,\tO\nsaid\tO\n:\tO\n\"\tO\nI\tO\nwould\tO\nlike\tO\nto\tO\ncome\tO\nback\tO\nand\tO\nplay\tO\ncounty\tO\ncricket\tO\nin\tO\nthe\tO\nfuture\tO\nand\tO\nI\tO\ndo\tO\nn't\tO\nthink\tO\nI\tO\nwould\tO\nlike\tO\nto\tO\nswap\tO\ncounties\tO\n.\tO\n\"\tO\n\nExplaining\tT-0\nhis\tO\npremature\tO\ndeparture\tO\nwas\tO\nunavoidable\tO\n,\tO\nPollock\tB-PER\nsaid\tT-1\n:\tO\n\"\tO\nI\tO\nhave\tO\nbeen\tO\ncarrying\tO\nthe\tO\ninjury\tO\nfor\tO\na\tO\nwhile\tO\nand\tO\nI\tO\nhope\tO\nthat\tO\nby\tO\nhaving\tO\nthe\tO\nsurgery\tO\nnow\tO\nI\tO\nwill\tO\nbe\tO\nable\tO\nto\tO\nlast\tO\nout\tO\nthe\tO\nnew\tO\nseason\tO\nback\tO\nhome\tO\n.\tO\n\"\tO\n\nCRICKET\tO\n-\tO\nENGLAND\tB-LOC\nV\tO\nPAKISTAN\tT-0\nFINAL\tT-1\nTEST\tO\nSCOREBOARD\tO\n.\tO\n\nCRICKET\tO\n-\tO\nENGLAND\tT-0\nV\tT-1\nPAKISTAN\tB-LOC\nFINAL\tO\nTEST\tO\nSCOREBOARD\tO\n.\tO\n\nthe\tO\nthird\tO\nand\tO\nfinal\tT-1\ntest\tT-1\nbetween\tO\nEngland\tB-LOC\nand\tO\nPakistan\tT-0\nat\tO\nThe\tO\n\nthe\tO\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nbetween\tT-1\nEngland\tT-2\nand\tT-0\nPakistan\tB-LOC\nat\tO\nThe\tO\n\nthe\tO\nthird\tO\nand\tO\nfinal\tO\ntest\tT-0\nbetween\tT-0\nEngland\tT-0\nand\tT-0\nPakistan\tT-0\nat\tT-0\nThe\tB-LOC\n\nEngland\tB-LOC\nfirst\tT-0\ninnings\tO\n\nM.\tB-PER\nAtherton\tI-PER\nb\tT-0\nWaqar\tT-1\nYounis\tT-2\n31\tO\n\nM.\tT-0\nAtherton\tT-0\nb\tO\nWaqar\tB-PER\nYounis\tI-PER\n31\tO\n\nA.\tB-PER\nStewart\tI-PER\nb\tO\nMushtaq\tT-0\nAhmed\tT-0\n44\tO\n\nA.\tO\nStewart\tT-1\nb\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n44\tT-0\n\nN.\tB-PER\nHussain\tI-PER\nc\tT-0\nSaeed\tT-1\nAnwar\tT-1\nb\tO\nWaqar\tO\nYounis\tO\n12\tO\n\nN.\tT-0\nHussain\tT-0\nc\tO\nSaeed\tB-PER\nAnwar\tI-PER\nb\tO\nWaqar\tO\nYounis\tO\n12\tO\n\nN.\tO\nHussain\tO\nc\tO\nSaeed\tT-0\nAnwar\tT-0\nb\tT-1\nWaqar\tB-PER\nYounis\tI-PER\n12\tO\n\nG.\tB-PER\nThorpe\tI-PER\nlbw\tT-0\nb\tT-1\nMohammad\tT-3\nAkram\tT-4\n54\tO\n\nG.\tO\nThorpe\tO\nlbw\tT-1\nb\tO\nMohammad\tB-PER\nAkram\tI-PER\n54\tT-0\n\nJ.\tB-PER\nCrawley\tI-PER\nb\tO\nWaqar\tT-0\nYounis\tT-0\n106\tO\n\nJ.\tO\nCrawley\tO\nb\tT-0\nWaqar\tB-PER\nYounis\tI-PER\n106\tO\n\nN.\tB-PER\nKnight\tI-PER\nb\tO\nMushtaq\tO\nAhmed\tT-0\n17\tO\n\nN.\tT-0\nKnight\tT-0\nb\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n17\tO\n\nC.\tB-PER\nLewis\tI-PER\nb\tO\nWasim\tT-0\nAkram\tT-0\n5\tO\n\nC.\tO\nLewis\tT-0\nb\tT-0\nWasim\tB-PER\nAkram\tI-PER\n5\tO\n\nI.\tB-PER\nSalisbury\tI-PER\nc\tO\nInzamam-ul-Haq\tT-0\nb\tO\nWasim\tO\nAkram\tO\n5\tT-0\n\nI.\tO\nSalisbury\tT-0\nc\tO\nInzamam-ul-Haq\tB-PER\nb\tO\nWasim\tO\nAkram\tO\n5\tO\n\nI.\tO\nSalisbury\tO\nc\tO\nInzamam-ul-Haq\tO\nb\tO\nWasim\tB-PER\nAkram\tI-PER\n5\tT-0\n\nD.\tB-PER\nCork\tI-PER\nc\tO\nMoin\tT-0\nKhan\tT-0\nb\tO\nWaqar\tT-1\nYounis\tT-1\n0\tO\n\nD.\tO\nCork\tO\nc\tO\nMoin\tB-PER\nKhan\tI-PER\nb\tO\nWaqar\tO\nYounis\tO\n0\tT-0\n\nD.\tT-1\nCork\tT-1\nc\tO\nMoin\tO\nKhan\tO\nb\tT-0\nWaqar\tB-PER\nYounis\tI-PER\n0\tO\n\nR.\tB-PER\nCroft\tI-PER\nnot\tO\nout\tO\n5\tT-0\n\nA.\tB-PER\nMullally\tI-PER\nb\tT-0\nWasim\tO\nAkram\tO\n24\tO\n\nA.\tO\nMullally\tT-1\nb\tT-0\nWasim\tB-PER\nAkram\tI-PER\n24\tO\n\nBowling\tT-0\n:\tO\nWasim\tB-PER\nAkram\tI-PER\n29.2-9-83-3\tO\n,\tO\nWaqar\tT-1\nYounis\tT-1\n25-6-95-4\tO\n,\tO\n\nBowling\tO\n:\tO\nWasim\tO\nAkram\tT-0\n29.2-9-83-3\tO\n,\tO\nWaqar\tB-PER\nYounis\tI-PER\n25-6-95-4\tO\n,\tO\n\nMohammad\tB-PER\nAkram\tI-PER\n12-1-41-1\tT-0\n,\tO\nMushtaq\tT-1\nAhmed\tT-1\n27-5-78-2\tO\n,\tO\nAamir\tO\nSohail\tO\n\nMohammad\tT-0\nAkram\tT-0\n12-1-41-1\tO\n,\tO\nMushtaq\tO\nAhmed\tO\n27-5-78-2\tO\n,\tO\nAamir\tB-PER\nSohail\tI-PER\n\nPakistan\tB-LOC\nfirst\tT-0\ninnings\tO\n\nSaeed\tB-PER\nAnwar\tI-PER\nnot\tT-0\nout\tT-0\n116\tO\n\nAamir\tB-PER\nSohail\tI-PER\nc\tO\nCork\tT-0\nb\tO\nCroft\tO\n46\tO\n\nAamir\tT-1\nSohail\tT-1\nc\tO\nCork\tB-PER\nb\tT-0\nCroft\tT-0\n46\tT-0\n\nIjaz\tB-PER\nAhmed\tI-PER\nnot\tO\nout\tT-0\n58\tO\n\nTo\tO\nbat\tT-0\n:\tO\nInzamam-ul-Haq\tB-PER\n,\tO\nSalim\tO\nMalik\tO\n,\tO\nAsif\tO\nMujtaba\tO\n,\tO\nWasim\tO\n\nTo\tO\nbat\tO\n:\tO\nInzamam-ul-Haq\tT-0\n,\tO\nSalim\tB-PER\nMalik\tI-PER\n,\tO\nAsif\tO\nMujtaba\tO\n,\tO\nWasim\tO\n\nTo\tT-0\nbat\tT-0\n:\tO\nInzamam-ul-Haq\tO\n,\tO\nSalim\tO\nMalik\tO\n,\tO\nAsif\tB-PER\nMujtaba\tI-PER\n,\tO\nWasim\tO\n\nTo\tT-0\nbat\tT-0\n:\tO\nInzamam-ul-Haq\tO\n,\tO\nSalim\tO\nMalik\tO\n,\tO\nAsif\tO\nMujtaba\tO\n,\tO\nWasim\tB-PER\n\nAkram\tB-PER\n,\tO\nMoin\tT-0\nKhan\tT-0\n,\tO\nMushtaq\tO\nAhmed\tO\n,\tO\nWaqar\tO\nYounis\tO\n,\tO\nMohammad\tO\nAkam\tO\n\nAkram\tT-3\n,\tO\nMoin\tB-PER\nKhan\tI-PER\n,\tO\nMushtaq\tT-0\nAhmed\tT-0\n,\tO\nWaqar\tT-1\nYounis\tT-1\n,\tO\nMohammad\tT-2\nAkam\tT-2\n\nAkram\tT-0\n,\tO\nMoin\tT-1\nKhan\tT-1\n,\tO\nMushtaq\tO\nAhmed\tO\n,\tO\nWaqar\tB-PER\nYounis\tI-PER\n,\tO\nMohammad\tT-2\nAkam\tT-2\n\nAkram\tT-0\n,\tO\nMoin\tO\nKhan\tO\n,\tO\nMushtaq\tO\nAhmed\tO\n,\tO\nWaqar\tO\nYounis\tO\n,\tO\nMohammad\tB-PER\nAkam\tI-PER\n\nBowling\tO\n(\tO\nto\tO\ndate\tO\n)\tO\n:\tO\nLewis\tT-0\n9-1-49-0\tO\n,\tO\nMullally\tB-PER\n9-3-28-0\tO\n,\tO\nCroft\tT-1\n\nBowling\tT-0\n(\tO\nto\tO\ndate\tO\n)\tO\n:\tO\nLewis\tT-1\n9-1-49-0\tO\n,\tO\nMullally\tO\n9-3-28-0\tO\n,\tO\nCroft\tB-PER\n\n17-3-42-1\tO\n,\tO\nCork\tB-PER\n7-1-38-0\tO\n,\tO\nSalisbury\tT-0\n14-0-71-0\tO\n\n17-3-42-1\tO\n,\tO\nCork\tT-0\n7-1-38-0\tO\n,\tO\nSalisbury\tB-PER\n14-0-71-0\tO\n\nCRICKET\tT-0\n-\tO\nENGLAND\tB-LOC\n326\tT-2\nALL\tO\nOUT\tO\nV\tO\nPAKISTAN\tT-1\nIN\tO\nTHIRD\tO\nTEST\tO\n.\tO\n\nCRICKET\tO\n-\tO\nENGLAND\tO\n326\tO\nALL\tO\nOUT\tO\nV\tO\nPAKISTAN\tB-LOC\nIN\tT-0\nTHIRD\tO\nTEST\tT-1\n.\tO\n\nEngland\tB-LOC\nwere\tT-2\nall\tO\nout\tO\nfor\tO\n326\tO\nin\tO\ntheir\tO\nfirst\tO\ninnings\tO\non\tO\nthe\tO\nsecond\tO\nday\tT-1\nof\tO\nthe\tO\nthird\tT-0\nand\tT-0\nfinal\tT-0\ntest\tT-0\nagainst\tO\nPakistan\tO\nat\tO\nThe\tO\nOval\tO\non\tO\nFriday\tO\n.\tO\n\nEngland\tT-1\nwere\tO\nall\tO\nout\tO\nfor\tO\n326\tO\nin\tO\ntheir\tO\nfirst\tO\ninnings\tT-2\non\tO\nthe\tO\nsecond\tO\nday\tO\nof\tO\nthe\tO\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nagainst\tO\nPakistan\tB-LOC\nat\tT-0\nThe\tT-0\nOval\tT-0\non\tO\nFriday\tO\n.\tO\n\nEngland\tO\nwere\tO\nall\tO\nout\tO\nfor\tO\n326\tO\nin\tO\ntheir\tO\nfirst\tO\ninnings\tT-0\non\tO\nthe\tO\nsecond\tO\nday\tO\nof\tO\nthe\tO\nthird\tO\nand\tO\nfinal\tO\ntest\tO\nagainst\tO\nPakistan\tO\nat\tO\nThe\tB-LOC\nOval\tI-LOC\non\tO\nFriday\tO\n.\tO\n\nScore\tO\n:\tO\nEngland\tB-LOC\n326\tT-0\n(\tO\nJ.\tT-1\nCrawley\tT-1\n106\tO\n,\tO\nG.\tT-2\nThorpe\tT-2\n54\tO\n.\tO\n\nScore\tO\n:\tO\nEngland\tO\n326\tO\n(\tO\nJ.\tB-PER\nCrawley\tI-PER\n106\tO\n,\tO\nG.\tT-0\nThorpe\tT-0\n54\tO\n.\tO\n\nScore\tO\n:\tO\nEngland\tT-0\n326\tO\n(\tO\nJ.\tO\nCrawley\tO\n106\tO\n,\tO\nG.\tB-PER\nThorpe\tI-PER\n54\tT-1\n.\tO\n\nSOCCER\tO\n-\tO\nSPONSORS\tT-1\nCASH\tT-0\nIN\tT-0\nON\tO\nRAVANELLI\tB-PER\n'S\tO\nSHIRT\tO\nDANCE\tO\n.\tO\n\nMiddlesbrough\tB-ORG\n's\tO\nItalian\tO\nstriker\tT-0\nFabrizio\tO\nRavanelli\tO\nis\tO\nto\tO\nwear\tO\nhis\tO\nteam\tT-1\nsponsor\tO\n's\tO\nname\tO\non\tO\nthe\tO\ninside\tO\nof\tO\nhis\tO\nshirt\tO\nso\tO\nit\tO\ncan\tO\nbe\tO\nseen\tO\nwhen\tO\nhe\tO\nscores\tO\n.\tO\n\nMiddlesbrough\tT-0\n's\tT-0\nItalian\tB-MISC\nstriker\tO\nFabrizio\tO\nRavanelli\tO\nis\tO\nto\tO\nwear\tT-1\nhis\tO\nteam\tO\nsponsor\tO\n's\tO\nname\tO\non\tO\nthe\tO\ninside\tO\nof\tO\nhis\tO\nshirt\tO\nso\tO\nit\tO\ncan\tO\nbe\tO\nseen\tO\nwhen\tO\nhe\tO\nscores\tO\n.\tO\n\nMiddlesbrough\tT-3\n's\tO\nItalian\tO\nstriker\tT-0\nFabrizio\tB-PER\nRavanelli\tI-PER\nis\tO\nto\tO\nwear\tT-1\nhis\tO\nteam\tO\nsponsor\tO\n's\tO\nname\tO\non\tO\nthe\tO\ninside\tO\nof\tO\nhis\tO\nshirt\tO\nso\tO\nit\tO\ncan\tO\nbe\tO\nseen\tT-2\nwhen\tO\nhe\tO\nscores\tO\n.\tO\n\nEvery\tO\ntime\tO\nhe\tO\nfinds\tO\nthe\tO\nnet\tO\n,\tO\nthe\tO\ngrey-haired\tO\nforward\tO\npulls\tT-2\nhis\tO\nshirtfront\tO\nover\tO\nhis\tO\nhead\tO\nas\tO\nhe\tO\nruns\tO\nto\tO\nsalute\tT-0\nthe\tO\nfans\tO\n,\tO\nand\tO\nMiddlesbrough\tB-ORG\n's\tO\nsponsors\tT-3\nwant\tO\nto\tO\ncash\tO\nin\tO\non\tO\nthe\tO\nspectacle\tT-1\n.\tO\n\n\"\tO\nHaving\tO\nseen\tT-0\nRavanelli\tB-PER\ncelebrate\tT-1\nhis\tO\ngoals\tO\n...\tO\n\nRavanelli\tB-PER\naggravated\tO\na\tO\nfoot\tO\ninjury\tO\nin\tO\nthe\tO\n1-0\tO\ndefeat\tO\nat\tO\nChelsea\tO\non\tO\nWednesday\tO\nand\tO\nwas\tO\ngiven\tT-0\nonly\tO\nan\tO\neven\tO\nchance\tO\nof\tO\nplaying\tO\nat\tO\nNottingham\tT-2\nForest\tO\non\tO\nSaturday\tO\nby\tO\nhis\tT-1\nmanager\tT-1\nBryan\tO\nRobson\tO\n.\tO\n\nRavanelli\tO\naggravated\tO\na\tO\nfoot\tO\ninjury\tO\nin\tO\nthe\tO\n1-0\tO\ndefeat\tO\nat\tO\nChelsea\tB-ORG\non\tT-2\nWednesday\tT-2\nand\tO\nwas\tO\ngiven\tO\nonly\tO\nan\tO\neven\tO\nchance\tO\nof\tO\nplaying\tT-0\nat\tO\nNottingham\tO\nForest\tO\non\tO\nSaturday\tO\nby\tO\nhis\tO\nmanager\tT-1\nBryan\tO\nRobson\tO\n.\tO\n\nRavanelli\tO\naggravated\tT-3\na\tO\nfoot\tO\ninjury\tT-1\nin\tO\nthe\tO\n1-0\tO\ndefeat\tT-2\nat\tO\nChelsea\tT-0\non\tO\nWednesday\tO\nand\tO\nwas\tO\ngiven\tO\nonly\tO\nan\tO\neven\tO\nchance\tO\nof\tO\nplaying\tO\nat\tO\nNottingham\tB-LOC\nForest\tI-LOC\non\tO\nSaturday\tO\nby\tO\nhis\tO\nmanager\tO\nBryan\tO\nRobson\tO\n.\tO\n\nRavanelli\tT-1\naggravated\tT-0\na\tO\nfoot\tO\ninjury\tO\nin\tO\nthe\tO\n1-0\tO\ndefeat\tO\nat\tO\nChelsea\tO\non\tO\nWednesday\tO\nand\tO\nwas\tO\ngiven\tO\nonly\tO\nan\tO\neven\tO\nchance\tO\nof\tO\nplaying\tO\nat\tO\nNottingham\tO\nForest\tO\non\tO\nSaturday\tO\nby\tO\nhis\tO\nmanager\tT-2\nBryan\tB-PER\nRobson\tI-PER\n.\tO\n\nTENNIS\tO\n-\tO\nAUSTRALIANS\tB-MISC\nADVANCE\tO\nAT\tO\nCANADIAN\tO\nOPEN\tT-0\n.\tO\n\nTENNIS\tO\n-\tO\nAUSTRALIANS\tT-0\nADVANCE\tO\nAT\tO\nCANADIAN\tB-MISC\nOPEN\tI-MISC\n.\tO\n\nIt\tO\nwas\tO\nAustralia\tB-MISC\nDay\tI-MISC\nat\tO\nthe\tO\n$\tT-1\n2\tT-1\nmillion\tT-1\nCanadian\tT-1\nOpen\tT-1\non\tO\nThursday\tO\nas\tO\nthree\tO\nAussies\tT-2\nreached\tT-0\nthe\tO\nquarter-finals\tT-3\nwith\tO\nstraight-set\tO\nvictories\tO\n.\tO\n\nIt\tO\nwas\tO\nAustralia\tT-2\nDay\tT-2\nat\tO\nthe\tO\n$\tO\n2\tT-0\nmillion\tT-0\nCanadian\tB-MISC\nOpen\tI-MISC\non\tO\nThursday\tT-1\nas\tO\nthree\tO\nAussies\tO\nreached\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nstraight-set\tO\nvictories\tO\n.\tO\n\nIt\tO\nwas\tO\nAustralia\tT-0\nDay\tT-0\nat\tO\nthe\tO\n$\tO\n2\tO\nmillion\tO\nCanadian\tT-1\nOpen\tT-1\non\tO\nThursday\tO\nas\tO\nthree\tO\nAussies\tB-MISC\nreached\tO\nthe\tO\nquarter-finals\tO\nwith\tO\nstraight-set\tO\nvictories\tO\n.\tO\n\nUnseeded\tT-1\nPatrick\tB-PER\nRafter\tI-PER\nrecorded\tO\nthe\tO\nmost\tO\nnoteworthy\tT-0\nresult\tO\nas\tO\nhe\tO\nupset\tT-2\nsixth-seeded\tT-2\nAmerican\tO\nMaliVai\tO\nWashington\tO\n6-2\tO\n6-1\tO\nin\tO\njust\tO\n50\tO\nminutes\tO\n.\tO\n\nUnseeded\tO\nPatrick\tO\nRafter\tO\nrecorded\tT-0\nthe\tO\nmost\tO\nnoteworthy\tO\nresult\tO\nas\tO\nhe\tO\nupset\tT-1\nsixth-seeded\tO\nAmerican\tB-MISC\nMaliVai\tT-2\nWashington\tT-2\n6-2\tO\n6-1\tO\nin\tO\njust\tO\n50\tO\nminutes\tO\n.\tO\n\nUnseeded\tO\nPatrick\tT-2\nRafter\tT-2\nrecorded\tO\nthe\tO\nmost\tO\nnoteworthy\tT-1\nresult\tO\nas\tO\nhe\tO\nupset\tO\nsixth-seeded\tT-0\nAmerican\tT-0\nMaliVai\tB-PER\nWashington\tI-PER\n6-2\tO\n6-1\tO\nin\tO\njust\tO\n50\tO\nminutes\tO\n.\tO\n\nTodd\tB-PER\nWoodbridge\tI-PER\n,\tO\nwho\tT-0\ndefeated\tT-1\nCanadian\tT-2\nDaniel\tT-2\nNestor\tT-2\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n,\tO\nand\tO\nMark\tT-3\nPhilippoussis\tT-3\n,\tO\na\tO\n6-3\tO\n6-4\tO\nwinner\tO\nover\tO\nBohdan\tT-4\nUlihrach\tT-4\nof\tO\nthe\tO\nCzech\tO\nRepublic\tO\n,\tO\nalso\tO\nadvanced\tO\nand\tO\nwill\tO\nmeet\tO\nin\tO\nFriday\tO\n's\tO\nquarter-finals\tO\n.\tO\n\nTodd\tT-5\nWoodbridge\tT-5\n,\tO\nwho\tO\ndefeated\tT-4\nCanadian\tB-MISC\nDaniel\tT-1\nNestor\tT-1\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n,\tO\nand\tO\nMark\tT-0\nPhilippoussis\tT-0\n,\tO\na\tO\n6-3\tO\n6-4\tO\nwinner\tO\nover\tO\nBohdan\tT-2\nUlihrach\tT-2\nof\tO\nthe\tO\nCzech\tT-3\nRepublic\tT-3\n,\tO\nalso\tO\nadvanced\tO\nand\tO\nwill\tO\nmeet\tO\nin\tO\nFriday\tO\n's\tO\nquarter-finals\tO\n.\tO\n\nTodd\tO\nWoodbridge\tO\n,\tO\nwho\tO\ndefeated\tO\nCanadian\tT-1\nDaniel\tB-PER\nNestor\tI-PER\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n,\tO\nand\tO\nMark\tO\nPhilippoussis\tT-0\n,\tO\na\tO\n6-3\tO\n6-4\tO\nwinner\tO\nover\tO\nBohdan\tO\nUlihrach\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tO\n,\tO\nalso\tO\nadvanced\tO\nand\tO\nwill\tO\nmeet\tO\nin\tO\nFriday\tO\n's\tO\nquarter-finals\tO\n.\tO\n\nTodd\tO\nWoodbridge\tO\n,\tO\nwho\tO\ndefeated\tT-1\nCanadian\tO\nDaniel\tO\nNestor\tO\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n,\tO\nand\tT-0\nMark\tB-PER\nPhilippoussis\tI-PER\n,\tO\na\tO\n6-3\tO\n6-4\tO\nwinner\tT-2\nover\tO\nBohdan\tO\nUlihrach\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tO\n,\tO\nalso\tO\nadvanced\tO\nand\tO\nwill\tO\nmeet\tO\nin\tO\nFriday\tO\n's\tO\nquarter-finals\tO\n.\tO\n\nTodd\tO\nWoodbridge\tO\n,\tO\nwho\tO\ndefeated\tO\nCanadian\tO\nDaniel\tO\nNestor\tO\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n,\tO\nand\tO\nMark\tO\nPhilippoussis\tO\n,\tO\na\tO\n6-3\tO\n6-4\tO\nwinner\tT-0\nover\tO\nBohdan\tB-PER\nUlihrach\tI-PER\nof\tT-1\nthe\tT-1\nCzech\tT-1\nRepublic\tT-1\n,\tO\nalso\tO\nadvanced\tO\nand\tO\nwill\tO\nmeet\tO\nin\tO\nFriday\tO\n's\tO\nquarter-finals\tO\n.\tO\n\nTodd\tT-2\nWoodbridge\tT-2\n,\tO\nwho\tO\ndefeated\tO\nCanadian\tT-3\nDaniel\tT-3\nNestor\tT-3\n7-6\tO\n(\tO\n7-2\tO\n)\tO\n7-6\tO\n(\tO\n7-4\tO\n)\tO\n,\tO\nand\tO\nMark\tT-4\nPhilippoussis\tT-4\n,\tO\na\tO\n6-3\tO\n6-4\tO\nwinner\tO\nover\tO\nBohdan\tT-5\nUlihrach\tT-5\nof\tO\nthe\tT-1\nCzech\tB-LOC\nRepublic\tI-LOC\n,\tO\nalso\tO\nadvanced\tO\nand\tO\nwill\tO\nmeet\tO\nin\tO\nFriday\tO\n's\tO\nquarter-finals\tO\n.\tO\n\nThird-seeded\tO\nWayne\tB-PER\nFerreira\tI-PER\nof\tO\nSouth\tO\nAfrica\tO\ndefeated\tT-2\nTim\tO\nHenman\tO\nof\tO\nBritain\tO\n6-4\tO\n6-4\tO\nafter\tO\na\tO\nthree-hour\tO\nevening\tO\nrain\tO\ndelay\tO\nand\tO\nfifth-seeded\tO\nThomas\tO\nEnqvist\tO\nof\tO\nSweden\tO\nwon\tT-3\nhis\tO\nthird-round\tO\nmatch\tO\n,\tO\neliminating\tT-0\nPetr\tO\nKorda\tO\nof\tO\nthe\tO\nCzech\tT-1\nRepublic\tT-1\n6-3\tO\n6-4\tO\n.\tO\n\nThird-seeded\tO\nWayne\tT-1\nFerreira\tT-1\nof\tO\nSouth\tB-LOC\nAfrica\tI-LOC\ndefeated\tO\nTim\tT-2\nHenman\tT-2\nof\tO\nBritain\tO\n6-4\tO\n6-4\tO\nafter\tO\na\tO\nthree-hour\tO\nevening\tO\nrain\tO\ndelay\tO\nand\tO\nfifth-seeded\tO\nThomas\tT-3\nEnqvist\tT-3\nof\tO\nSweden\tO\nwon\tO\nhis\tO\nthird-round\tO\nmatch\tO\n,\tO\neliminating\tO\nPetr\tO\nKorda\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tO\n6-3\tO\n6-4\tO\n.\tO\n\nThird-seeded\tO\nWayne\tT-0\nFerreira\tT-0\nof\tO\nSouth\tO\nAfrica\tO\ndefeated\tO\nTim\tB-PER\nHenman\tI-PER\nof\tO\nBritain\tO\n6-4\tO\n6-4\tO\nafter\tO\na\tO\nthree-hour\tO\nevening\tO\nrain\tO\ndelay\tO\nand\tO\nfifth-seeded\tO\nThomas\tT-1\nEnqvist\tT-1\nof\tO\nSweden\tO\nwon\tT-2\nhis\tO\nthird-round\tO\nmatch\tO\n,\tO\neliminating\tT-3\nPetr\tO\nKorda\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tO\n6-3\tO\n6-4\tO\n.\tO\n\nThird-seeded\tO\nWayne\tO\nFerreira\tO\nof\tO\nSouth\tO\nAfrica\tO\ndefeated\tO\nTim\tO\nHenman\tT-1\nof\tT-2\nBritain\tB-LOC\n6-4\tO\n6-4\tO\nafter\tO\na\tO\nthree-hour\tO\nevening\tO\nrain\tO\ndelay\tO\nand\tO\nfifth-seeded\tO\nThomas\tO\nEnqvist\tO\nof\tO\nSweden\tO\nwon\tT-0\nhis\tO\nthird-round\tO\nmatch\tO\n,\tO\neliminating\tO\nPetr\tO\nKorda\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tO\n6-3\tO\n6-4\tO\n.\tO\n\nThird-seeded\tO\nWayne\tO\nFerreira\tO\nof\tO\nSouth\tO\nAfrica\tO\ndefeated\tT-2\nTim\tO\nHenman\tT-0\nof\tO\nBritain\tO\n6-4\tO\n6-4\tO\nafter\tO\na\tO\nthree-hour\tO\nevening\tO\nrain\tO\ndelay\tO\nand\tO\nfifth-seeded\tO\nThomas\tB-PER\nEnqvist\tI-PER\nof\tO\nSweden\tO\nwon\tT-3\nhis\tO\nthird-round\tO\nmatch\tO\n,\tO\neliminating\tT-4\nPetr\tO\nKorda\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tT-1\n6-3\tO\n6-4\tO\n.\tO\n\nThird-seeded\tO\nWayne\tT-1\nFerreira\tT-1\nof\tO\nSouth\tO\nAfrica\tO\ndefeated\tO\nTim\tT-2\nHenman\tT-2\nof\tO\nBritain\tO\n6-4\tO\n6-4\tO\nafter\tO\na\tO\nthree-hour\tO\nevening\tO\nrain\tO\ndelay\tO\nand\tO\nfifth-seeded\tO\nThomas\tT-3\nEnqvist\tT-3\nof\tO\nSweden\tB-LOC\nwon\tO\nhis\tO\nthird-round\tO\nmatch\tT-0\n,\tO\neliminating\tT-4\nPetr\tO\nKorda\tO\nof\tO\nthe\tO\nCzech\tO\nRepublic\tO\n6-3\tO\n6-4\tO\n.\tO\n\nThird-seeded\tO\nWayne\tO\nFerreira\tO\nof\tO\nSouth\tO\nAfrica\tO\ndefeated\tT-1\nTim\tO\nHenman\tO\nof\tO\nBritain\tO\n6-4\tO\n6-4\tO\nafter\tO\na\tO\nthree-hour\tO\nevening\tO\nrain\tO\ndelay\tO\nand\tO\nfifth-seeded\tT-0\nThomas\tO\nEnqvist\tO\nof\tO\nSweden\tO\nwon\tO\nhis\tO\nthird-round\tO\nmatch\tO\n,\tO\neliminating\tO\nPetr\tB-PER\nKorda\tI-PER\nof\tT-2\nthe\tT-2\nCzech\tT-2\nRepublic\tT-2\n6-3\tO\n6-4\tO\n.\tO\n\nThird-seeded\tO\nWayne\tO\nFerreira\tO\nof\tO\nSouth\tO\nAfrica\tO\ndefeated\tO\nTim\tO\nHenman\tO\nof\tO\nBritain\tO\n6-4\tO\n6-4\tO\nafter\tO\na\tO\nthree-hour\tO\nevening\tO\nrain\tO\ndelay\tO\nand\tO\nfifth-seeded\tO\nThomas\tO\nEnqvist\tO\nof\tO\nSweden\tO\nwon\tO\nhis\tO\nthird-round\tO\nmatch\tO\n,\tO\neliminating\tO\nPetr\tT-0\nKorda\tT-1\nof\tT-2\nthe\tT-2\nCzech\tB-LOC\nRepublic\tI-LOC\n6-3\tO\n6-4\tO\n.\tO\n\nFerreira\tB-PER\nand\tT-0\nEnqvist\tT-1\nplay\tO\nin\tO\na\tO\nFriday\tO\nnight\tO\nquarter-final\tO\n.\tO\n\nFerreira\tT-0\nand\tO\nEnqvist\tB-PER\nplay\tT-1\nin\tO\na\tO\nFriday\tO\nnight\tO\nquarter-final\tO\n.\tO\n\nTwo\tT-3\nAmericans\tB-MISC\n,\tO\nseventh\tO\nseed\tO\nTodd\tT-0\nMartin\tT-0\nand\tO\nunseeded\tO\nAlex\tT-1\nO'Brien\tT-1\n,\tO\nwill\tO\nmeet\tT-2\non\tO\nFriday\tO\nafter\tO\nwinning\tO\nmatches\tO\non\tO\nThursday\tO\n.\tO\n\nTwo\tO\nAmericans\tO\n,\tO\nseventh\tT-0\nseed\tT-1\nTodd\tB-PER\nMartin\tI-PER\nand\tT-2\nunseeded\tO\nAlex\tO\nO'Brien\tO\n,\tO\nwill\tO\nmeet\tO\non\tO\nFriday\tO\nafter\tO\nwinning\tO\nmatches\tO\non\tO\nThursday\tO\n.\tO\n\nTwo\tO\nAmericans\tT-1\n,\tO\nseventh\tO\nseed\tO\nTodd\tT-0\nMartin\tT-0\nand\tO\nunseeded\tT-2\nAlex\tB-PER\nO'Brien\tI-PER\n,\tO\nwill\tO\nmeet\tO\non\tO\nFriday\tO\nafter\tO\nwinning\tT-3\nmatches\tO\non\tO\nThursday\tO\n.\tT-1\n\nMartin\tB-PER\novercame\tT-1\nCedric\tO\nPioline\tO\nof\tO\nFrance\tO\n2-6\tO\n6-2\tO\n6-4\tO\nand\tO\nO'Brien\tO\nbeat\tT-0\nMikael\tO\nTillstrom\tO\nof\tO\nSweden\tO\n6-3\tO\n2-6\tO\n6-3\tO\n.\tO\n\nMartin\tO\novercame\tT-0\nCedric\tB-PER\nPioline\tI-PER\nof\tO\nFrance\tO\n2-6\tO\n6-2\tO\n6-4\tO\nand\tO\nO'Brien\tO\nbeat\tO\nMikael\tO\nTillstrom\tO\nof\tO\nSweden\tO\n6-3\tO\n2-6\tO\n6-3\tO\n.\tO\n\nMartin\tO\novercame\tO\nCedric\tT-1\nPioline\tT-1\nof\tT-0\nFrance\tB-LOC\n2-6\tO\n6-2\tO\n6-4\tO\nand\tO\nO'Brien\tO\nbeat\tO\nMikael\tO\nTillstrom\tO\nof\tO\nSweden\tT-2\n6-3\tO\n2-6\tO\n6-3\tO\n.\tO\n\nMartin\tT-0\novercame\tT-1\nCedric\tO\nPioline\tO\nof\tO\nFrance\tO\n2-6\tO\n6-2\tO\n6-4\tO\nand\tO\nO'Brien\tB-PER\nbeat\tT-2\nMikael\tO\nTillstrom\tO\nof\tO\nSweden\tO\n6-3\tO\n2-6\tO\n6-3\tO\n.\tO\n\nMartin\tO\novercame\tO\nCedric\tO\nPioline\tT-2\nof\tO\nFrance\tT-0\n2-6\tO\n6-2\tO\n6-4\tO\nand\tO\nO'Brien\tT-1\nbeat\tT-3\nMikael\tB-PER\nTillstrom\tI-PER\nof\tT-4\nSweden\tT-4\n6-3\tO\n2-6\tO\n6-3\tO\n.\tO\n\nMartin\tO\novercame\tT-0\nCedric\tO\nPioline\tO\nof\tO\nFrance\tO\n2-6\tO\n6-2\tO\n6-4\tO\nand\tO\nO'Brien\tO\nbeat\tT-1\nMikael\tO\nTillstrom\tO\nof\tT-2\nSweden\tB-LOC\n6-3\tO\n2-6\tO\n6-3\tO\n.\tO\n\n\"\tO\nIf\tO\nyou\tO\nreally\tO\nlook\tO\nat\tO\nthe\tO\nmatch\tO\n,\tO\n\"\tO\nsaid\tT-1\nthe\tO\n12th-ranked\tT-4\nWashington\tB-PER\nafter\tT-0\nlosing\tT-0\nto\tT-0\nthe\tT-0\n70th-ranked\tT-0\nRafter\tT-0\n,\tO\n\"\tO\nI\tO\nnever\tO\nreally\tO\ngot\tO\na\tO\nchance\tO\nto\tO\nplay\tO\nbecause\tO\nhe\tO\nwas\tO\nserving\tT-2\nbig\tO\nand\tO\ngetting\tT-3\nin\tO\nclose\tO\nto\tO\nthe\tO\nnet\tO\n.\tO\n\n\"\tO\nIf\tO\nyou\tO\nreally\tO\nlook\tO\nat\tO\nthe\tO\nmatch\tO\n,\tO\n\"\tO\nsaid\tT-0\nthe\tO\n12th-ranked\tO\nWashington\tO\nafter\tO\nlosing\tO\nto\tO\nthe\tT-1\n70th-ranked\tT-1\nRafter\tB-PER\n,\tO\n\"\tO\nI\tO\nnever\tO\nreally\tO\ngot\tO\na\tO\nchance\tO\nto\tO\nplay\tO\nbecause\tO\nhe\tO\nwas\tO\nserving\tO\nbig\tO\nand\tO\ngetting\tO\nin\tO\nclose\tO\nto\tO\nthe\tO\nnet\tO\n.\tO\n\nRafter\tB-PER\nmissed\tT-1\n10\tO\nweeks\tO\nafter\tO\nwrist\tT-0\nsurgery\tT-0\nearlier\tO\nthis\tO\nyear\tO\nand\tO\nthe\tO\ntime\tO\naway\tO\nfrom\tO\ntennis\tO\nhas\tO\ngiven\tT-2\nhim\tO\na\tO\nnew\tO\nperspective\tT-3\n.\tO\n\n\"\tO\nBefore\tO\nwhen\tO\nI\tO\nwas\tO\non\tT-2\ntour\tT-2\n,\tO\nI\tO\nalways\tO\nfelt\tO\nI\tO\nhad\tO\nto\tO\nbe\tO\nin\tO\nbed\tO\nby\tO\n9:30\tO\nor\tO\n10\tO\no'clock\tO\nand\tO\nI\tO\nhad\tO\nto\tO\nbe\tO\nup\tO\nat\tO\na\tO\ncertain\tT-1\ntime\tO\n,\tO\n\"\tO\nRafter\tB-PER\nsaid\tT-0\n.\tO\n\"\tO\n\nMartin\tB-PER\nwas\tO\npleased\tO\nwith\tO\nhis\tO\nvictory\tT-0\nover\tO\nPioline\tT-1\n,\tO\nhis\tO\nfirst\tO\nin\tO\nfive\tO\nmeetings\tO\nwith\tO\nthe\tO\n11th-ranked\tO\nFrenchman\tT-2\n.\tO\n\"\tO\n\nMartin\tO\nwas\tO\npleased\tO\nwith\tO\nhis\tO\nvictory\tT-2\nover\tO\nPioline\tB-PER\n,\tO\nhis\tT-3\nfirst\tO\nin\tO\nfive\tO\nmeetings\tO\nwith\tO\nthe\tO\n11th-ranked\tT-0\nFrenchman\tT-1\n.\tO\n\"\tO\n\nMartin\tO\nwas\tO\npleased\tT-1\nwith\tO\nhis\tO\nvictory\tO\nover\tO\nPioline\tO\n,\tO\nhis\tO\nfirst\tO\nin\tO\nfive\tO\nmeetings\tT-0\nwith\tO\nthe\tO\n11th-ranked\tO\nFrenchman\tB-MISC\n.\tO\n\"\tO\n\n\"\tO\nI\tO\ngot\tO\nmore\tO\naggressive\tT-0\nin\tO\nthe\tO\nsecond\tO\nand\tO\nthird\tO\nsets\tO\nand\tO\nthe\tO\nwind\tO\npicked\tO\nup\tO\nand\tO\nthat\tO\nalso\tO\naffected\tO\nthings\tO\nbecause\tO\nCedric\tB-PER\ndefinitely\tT-1\nwent\tO\noff\tO\na\tO\nlittle\tO\nbit\tO\n.\tO\n\"\tO\n\nThe\tO\n26-year-old\tO\nO'Brien\tB-PER\n,\tO\nwho\tO\nwon\tT-0\nthe\tO\nATP\tO\nTour\tO\nstop\tO\nin\tO\nNew\tO\nHaven\tO\nlast\tO\nweek\tO\n,\tO\nhas\tO\nnow\tO\nwon\tO\n18\tO\nof\tO\nhis\tO\nlast\tO\n20\tO\nmatches\tO\n,\tO\ndating\tO\nback\tO\nto\tO\nqualifying\tO\nrounds\tO\nin\tO\nLos\tO\nAngeles\tO\nin\tO\nlate\tO\nJuly\tO\n.\tO\n\nThe\tO\n26-year-old\tO\nO'Brien\tO\n,\tO\nwho\tO\nwon\tO\nthe\tO\nATP\tB-MISC\nTour\tI-MISC\nstop\tO\nin\tO\nNew\tO\nHaven\tO\nlast\tO\nweek\tO\n,\tO\nhas\tO\nnow\tO\nwon\tO\n18\tO\nof\tO\nhis\tO\nlast\tO\n20\tO\nmatches\tT-0\n,\tO\ndating\tO\nback\tO\nto\tO\nqualifying\tO\nrounds\tO\nin\tO\nLos\tO\nAngeles\tO\nin\tO\nlate\tO\nJuly\tO\n.\tO\n\nThe\tO\n26-year-old\tO\nO'Brien\tO\n,\tO\nwho\tO\nwon\tT-2\nthe\tO\nATP\tO\nTour\tT-0\nstop\tT-0\nin\tO\nNew\tB-LOC\nHaven\tI-LOC\nlast\tO\nweek\tO\n,\tO\nhas\tO\nnow\tO\nwon\tO\n18\tO\nof\tO\nhis\tO\nlast\tO\n20\tO\nmatches\tT-1\n,\tO\ndating\tO\nback\tO\nto\tO\nqualifying\tT-3\nrounds\tT-3\nin\tO\nLos\tO\nAngeles\tO\nin\tO\nlate\tO\nJuly\tO\n.\tO\n\nThe\tO\n26-year-old\tO\nO'Brien\tO\n,\tO\nwho\tO\nwon\tT-1\nthe\tO\nATP\tO\nTour\tO\nstop\tO\nin\tO\nNew\tT-0\nHaven\tT-0\nlast\tO\nweek\tO\n,\tO\nhas\tO\nnow\tO\nwon\tO\n18\tO\nof\tO\nhis\tO\nlast\tO\n20\tO\nmatches\tO\n,\tO\ndating\tO\nback\tO\nto\tO\nqualifying\tT-2\nrounds\tO\nin\tO\nLos\tB-LOC\nAngeles\tI-LOC\nin\tO\nlate\tO\nJuly\tO\n.\tO\n\n\"\tO\nI\tO\nfeel\tO\nI\tO\n'm\tO\nhitting\tO\nthe\tO\nball\tO\nwell\tO\neven\tO\nthough\tO\nI\tO\n'm\tO\nhaving\tO\nmore\tO\nmental\tT-0\nletdowns\tT-0\nthan\tO\nI\tO\ndid\tO\nlast\tO\nweek\tO\n,\tO\n\"\tO\nO'Brien\tB-PER\nsaid\tT-1\n.\tO\n\"\tO\n\n\"\tO\nI\tO\ngot\tO\na\tO\nlot\tO\nof\tO\nfirst\tO\nserves\tO\nin\tO\n,\tO\n\"\tO\nsaid\tO\nEnqvist\tB-PER\nabout\tO\nhis\tT-0\nvictory\tO\nover\tO\nKorda\tO\n.\tO\n\"\tO\n\n\"\tO\nI\tO\ngot\tT-1\na\tO\nlot\tO\nof\tO\nfirst\tO\nserves\tT-2\nin\tO\n,\tO\n\"\tO\nsaid\tO\nEnqvist\tT-0\nabout\tO\nhis\tO\nvictory\tO\nover\tO\nKorda\tB-PER\n.\tO\n\"\tO\n\nStill\tO\nmarvelling\tO\nat\tO\nan\tO\nexciting\tO\n64-stroke\tO\nrally\tO\nhe\tO\nwon\tT-2\nin\tO\nthe\tO\nlast\tO\ngame\tO\nof\tO\nhis\tO\nsecond-round\tO\nmatch\tO\nagainst\tT-0\nJavier\tB-PER\nSanchez\tI-PER\nof\tO\nSpain\tO\non\tO\nTuesday\tO\n,\tO\nEnqvist\tO\njoked\tT-1\n,\tO\n\"\tO\nToday\tO\nagainst\tO\nPetr\tO\nthere\tO\nwere\tO\nabout\tO\n64\tO\nstrokes\tO\nin\tO\nthe\tO\nwhole\tO\nmatch\tO\n.\tO\n\nStill\tO\nmarvelling\tO\nat\tO\nan\tO\nexciting\tO\n64-stroke\tO\nrally\tO\nhe\tO\nwon\tT-0\nin\tO\nthe\tO\nlast\tO\ngame\tO\nof\tO\nhis\tO\nsecond-round\tO\nmatch\tO\nagainst\tO\nJavier\tO\nSanchez\tO\nof\tT-2\nSpain\tB-LOC\non\tO\nTuesday\tO\n,\tO\nEnqvist\tO\njoked\tO\n,\tO\n\"\tO\nToday\tO\nagainst\tO\nPetr\tO\nthere\tO\nwere\tO\nabout\tO\n64\tT-1\nstrokes\tT-1\nin\tO\nthe\tO\nwhole\tO\nmatch\tO\n.\tO\n\nStill\tO\nmarvelling\tO\nat\tO\nan\tO\nexciting\tO\n64-stroke\tO\nrally\tO\nhe\tT-1\nwon\tO\nin\tO\nthe\tO\nlast\tO\ngame\tO\nof\tO\nhis\tO\nsecond-round\tO\nmatch\tO\nagainst\tO\nJavier\tO\nSanchez\tO\nof\tO\nSpain\tO\non\tO\nTuesday\tO\n,\tO\nEnqvist\tB-PER\njoked\tT-0\n,\tO\n\"\tO\nToday\tO\nagainst\tO\nPetr\tO\nthere\tO\nwere\tO\nabout\tO\n64\tO\nstrokes\tO\nin\tO\nthe\tO\nwhole\tO\nmatch\tO\n.\tO\n\nStill\tO\nmarvelling\tO\nat\tO\nan\tO\nexciting\tO\n64-stroke\tO\nrally\tO\nhe\tT-1\nwon\tT-1\nin\tO\nthe\tO\nlast\tO\ngame\tO\nof\tO\nhis\tO\nsecond-round\tO\nmatch\tO\nagainst\tT-2\nJavier\tT-2\nSanchez\tT-2\nof\tO\nSpain\tO\non\tO\nTuesday\tO\n,\tO\nEnqvist\tO\njoked\tO\n,\tO\n\"\tO\nToday\tO\nagainst\tT-3\nPetr\tB-PER\nthere\tO\nwere\tT-0\nabout\tO\n64\tO\nstrokes\tO\nin\tO\nthe\tO\nwhole\tO\nmatch\tO\n.\tO\n\nTENNIS\tT-0\n-\tO\nRESULTS\tO\nAT\tO\nCANADIAN\tB-MISC\nOPEN\tI-MISC\n.\tO\n\nResults\tT-1\nfrom\tT-0\nthe\tT-0\nCanadian\tB-MISC\nOpen\tI-MISC\n\n3\tO\n-\tO\nWayne\tB-PER\nFerreira\tI-PER\n(\tO\nSouth\tT-2\nAfrica\tT-2\n)\tO\nbeat\tT-1\nTim\tT-0\nHenman\tT-0\n(\tO\nBritain\tT-3\n)\tO\n6-4\tO\n\n3\tO\n-\tO\nWayne\tT-0\nFerreira\tT-0\n(\tO\nSouth\tB-LOC\nAfrica\tI-LOC\n)\tO\nbeat\tT-2\nTim\tT-1\nHenman\tT-1\n(\tO\nBritain\tO\n)\tO\n6-4\tO\n\n3\tO\n-\tO\nWayne\tO\nFerreira\tO\n(\tO\nSouth\tT-0\nAfrica\tT-0\n)\tO\nbeat\tT-2\nTim\tB-PER\nHenman\tI-PER\n(\tO\nBritain\tT-1\n)\tO\n6-4\tO\n\n4\tO\n-\tO\nMarcelo\tB-PER\nRios\tI-PER\n(\tO\nChile\tO\n)\tO\nbeat\tT-0\nDaniel\tT-0\nVacek\tT-0\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\n6-4\tO\n\n4\tO\n-\tO\nMarcelo\tO\nRios\tO\n(\tO\nChile\tB-LOC\n)\tO\nbeat\tT-0\nDaniel\tT-0\nVacek\tT-0\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\n6-4\tO\n\n4\tO\n-\tO\nMarcelo\tT-0\nRios\tT-1\n(\tO\nChile\tO\n)\tO\nbeat\tO\nDaniel\tB-PER\nVacek\tI-PER\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\n6-4\tO\n\n4\tO\n-\tO\nMarcelo\tT-0\nRios\tT-0\n(\tO\nChile\tO\n)\tO\nbeat\tO\nDaniel\tO\nVacek\tO\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n6-4\tO\n\n5\tO\n-\tO\nThomas\tB-PER\nEnqvist\tI-PER\n(\tO\nSweden\tT-1\n)\tO\nbeat\tT-0\nPetr\tT-2\nKorda\tT-2\n(\tO\nCzech\tO\nRepublic\tO\n)\tO\n\n5\tO\n-\tO\nThomas\tO\nEnqvist\tO\n(\tO\nSweden\tB-LOC\n)\tO\nbeat\tT-0\nPetr\tT-0\nKorda\tT-0\n(\tT-0\nCzech\tT-0\nRepublic\tT-0\n)\tT-0\n\n5\tO\n-\tO\nThomas\tT-1\nEnqvist\tT-1\n(\tO\nSweden\tO\n)\tO\nbeat\tT-2\nPetr\tB-PER\nKorda\tI-PER\n(\tO\nCzech\tT-0\nRepublic\tT-0\n)\tO\n\n5\tO\n-\tO\nThomas\tO\nEnqvist\tO\n(\tO\nSweden\tT-1\n)\tO\nbeat\tO\nPetr\tT-0\nKorda\tT-0\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n\nPatrick\tO\nRafter\tO\n(\tO\nAustralia\tB-LOC\n)\tO\nbeat\tT-0\n6\tO\n-\tO\nMaliVai\tO\nWashington\tO\n(\tO\nU.S.\tO\n)\tO\n\nPatrick\tO\nRafter\tO\n(\tO\nAustralia\tO\n)\tO\nbeat\tO\n6\tO\n-\tO\nMaliVai\tB-PER\nWashington\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n\nPatrick\tT-0\nRafter\tT-0\n(\tO\nAustralia\tO\n)\tO\nbeat\tT-2\n6\tO\n-\tO\nMaliVai\tT-1\nWashington\tT-1\n(\tO\nU.S.\tB-LOC\n)\tO\n\n7\tO\n-\tO\nTodd\tB-PER\nMartin\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\nbeat\tO\n9\tO\n-\tO\nCedric\tO\nPioline\tO\n(\tO\nFrance\tT-1\n)\tO\n2-6\tO\n6-2\tO\n\n7\tO\n-\tO\nTodd\tT-0\nMartin\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tT-2\n9\tO\n-\tO\nCedric\tT-1\nPioline\tT-1\n(\tO\nFrance\tO\n)\tO\n2-6\tO\n6-2\tO\n\n7\tO\n-\tO\nTodd\tO\nMartin\tO\n(\tO\nU.S.\tO\n)\tO\nbeat\tT-1\n9\tO\n-\tO\nCedric\tB-PER\nPioline\tI-PER\n(\tO\nFrance\tO\n)\tO\n2-6\tO\n6-2\tO\n\n7\tO\n-\tO\nTodd\tT-2\nMartin\tT-2\n(\tO\nU.S.\tO\n)\tO\nbeat\tT-1\n9\tO\n-\tO\nCedric\tT-3\nPioline\tT-3\n(\tO\nFrance\tB-LOC\n)\tO\n2-6\tO\n6-2\tO\n\nMark\tB-PER\nPhilippoussis\tI-PER\n(\tO\nAustralia\tT-1\n)\tO\nbeat\tO\nBohdan\tT-0\nUlihrach\tT-0\n(\tO\nCzech\tO\n\nMark\tT-1\nPhilippoussis\tT-1\n(\tO\nAustralia\tB-LOC\n)\tO\nbeat\tT-0\nBohdan\tO\nUlihrach\tO\n(\tO\nCzech\tT-2\n\nMark\tT-0\nPhilippoussis\tT-0\n(\tO\nAustralia\tO\n)\tO\nbeat\tT-1\nBohdan\tB-PER\nUlihrach\tI-PER\n(\tO\nCzech\tO\n\nMark\tO\nPhilippoussis\tO\n(\tO\nAustralia\tT-1\n)\tO\nbeat\tT-0\nBohdan\tO\nUlihrach\tO\n(\tO\nCzech\tB-LOC\n\nAlex\tB-PER\nO'Brien\tI-PER\n(\tO\nU.S.\tO\n)\tO\nbeat\tT-0\nMikael\tT-0\nTillstrom\tT-0\n(\tO\nSweden\tO\n)\tO\n6-3\tO\n2-6\tO\n\nAlex\tO\nO'Brien\tO\n(\tO\nU.S.\tB-LOC\n)\tO\nbeat\tO\nMikael\tT-0\nTillstrom\tT-0\n(\tO\nSweden\tO\n)\tO\n6-3\tO\n2-6\tO\n\nAlex\tT-0\nO'Brien\tT-0\n(\tO\nU.S.\tO\n)\tO\nbeat\tT-1\nMikael\tB-PER\nTillstrom\tI-PER\n(\tO\nSweden\tT-2\n)\tO\n6-3\tO\n2-6\tO\n\nAlex\tT-1\nO'Brien\tT-1\n(\tO\nU.S.\tO\n)\tO\nbeat\tT-2\nMikael\tO\nTillstrom\tO\n(\tO\nSweden\tB-LOC\n)\tO\n6-3\tT-0\n2-6\tT-0\n\nTodd\tB-PER\nWoodbridge\tI-PER\n(\tO\nAustralia\tT-1\n)\tO\nbeat\tT-0\nDaniel\tO\nNestor\tO\n(\tO\nCanada\tO\n)\tO\n7-6\tO\n\nTodd\tO\nWoodbridge\tO\n(\tO\nAustralia\tB-LOC\n)\tO\nbeat\tO\nDaniel\tO\nNestor\tO\n(\tO\nCanada\tT-0\n)\tO\n7-6\tO\n\nTodd\tT-0\nWoodbridge\tT-0\n(\tO\nAustralia\tO\n)\tO\nbeat\tO\nDaniel\tB-PER\nNestor\tI-PER\n(\tO\nCanada\tO\n)\tO\n7-6\tO\n\nTodd\tO\nWoodbridge\tO\n(\tO\nAustralia\tT-0\n)\tO\nbeat\tT-1\nDaniel\tO\nNestor\tO\n(\tO\nCanada\tB-LOC\n)\tO\n7-6\tO\n\nRUGBY\tB-ORG\nUNION\tI-ORG\n-\tO\nMULDER\tO\nOUT\tT-1\nOF\tO\nSECOND\tO\nTEST\tT-0\n.\tO\n\nRUGBY\tT-1\nUNION\tT-1\n-\tO\nMULDER\tB-PER\nOUT\tT-2\nOF\tT-2\nSECOND\tO\nTEST\tT-0\n.\tO\n\nCentre\tT-0\nJapie\tB-PER\nMulder\tI-PER\nhas\tO\nbeen\tO\nruled\tT-1\nout\tT-3\nof\tT-3\nSouth\tO\nAfrica\tO\n's\tO\nteam\tO\nfor\tO\nthe\tO\nsecond\tO\ntest\tT-2\nagainst\tO\nNew\tO\nZealand\tO\nin\tO\nPretoria\tO\non\tO\nSaturday\tO\n.\tO\n\nCentre\tO\nJapie\tO\nMulder\tO\nhas\tT-0\nbeen\tT-0\nruled\tT-0\nout\tT-0\nof\tT-0\nSouth\tB-LOC\nAfrica\tI-LOC\n's\tO\nteam\tO\nfor\tO\nthe\tO\nsecond\tO\ntest\tT-1\nagainst\tO\nNew\tO\nZealand\tO\nin\tO\nPretoria\tO\non\tO\nSaturday\tO\n.\tO\n\nCentre\tT-2\nJapie\tT-2\nMulder\tT-2\nhas\tT-3\nbeen\tT-3\nruled\tT-3\nout\tT-3\nof\tO\nSouth\tT-0\nAfrica\tT-0\n's\tT-0\nteam\tT-0\nfor\tO\nthe\tO\nsecond\tO\ntest\tO\nagainst\tO\nNew\tB-LOC\nZealand\tI-LOC\nin\tO\nPretoria\tT-1\non\tO\nSaturday\tO\n.\tO\n\nMulder\tB-PER\nmissed\tT-1\nthe\tO\nfirst\tO\ntest\tO\nin\tO\nDurban\tO\nwith\tO\nback\tO\nspasms\tT-0\nand\tO\nfailed\tO\na\tO\nfitness\tO\ncheck\tO\non\tO\nThursday\tO\n.\tO\n\nMulder\tT-1\nmissed\tO\nthe\tO\nfirst\tT-0\ntest\tT-0\nin\tO\nDurban\tB-LOC\nwith\tO\nback\tO\nspasms\tO\nand\tO\nfailed\tO\na\tO\nfitness\tT-2\ncheck\tT-2\non\tO\nThursday\tO\n.\tO\n\nBut\tT-1\nnew\tT-1\nSpringbok\tB-ORG\nskipper\tT-0\nGary\tO\nTeichmann\tO\nhas\tO\nrecovered\tO\nfrom\tO\na\tO\nbruised\tO\nthigh\tO\nand\tO\nis\tO\nready\tO\nto\tO\nplay\tO\n,\tO\ncoach\tO\nAndre\tO\nMarkgraaff\tO\nsaid\tO\n.\tO\n\nBut\tO\nnew\tO\nSpringbok\tO\nskipper\tT-2\nGary\tB-PER\nTeichmann\tI-PER\nhas\tO\nrecovered\tT-0\nfrom\tO\na\tO\nbruised\tO\nthigh\tO\nand\tO\nis\tO\nready\tT-1\nto\tO\nplay\tO\n,\tO\ncoach\tO\nAndre\tO\nMarkgraaff\tO\nsaid\tO\n.\tO\n\nBut\tO\nnew\tO\nSpringbok\tO\nskipper\tO\nGary\tO\nTeichmann\tO\nhas\tO\nrecovered\tT-1\nfrom\tO\na\tO\nbruised\tO\nthigh\tO\nand\tO\nis\tO\nready\tT-2\nto\tT-2\nplay\tT-2\n,\tO\ncoach\tT-0\nAndre\tB-PER\nMarkgraaff\tI-PER\nsaid\tO\n.\tO\n\nMulder\tB-PER\n's\tO\nabsence\tO\nmeans\tO\nthat\tO\nNorthern\tT-1\nTransvaal\tT-1\ncentre\tT-0\nAndre\tT-2\nSnyman\tT-2\nshould\tO\nwin\tO\nhis\tO\nsecond\tO\ncap\tO\nalongside\tO\nprovincial\tO\ncolleague\tO\nDanie\tO\nvan\tO\nSchalkwyk\tO\n.\tO\n\nMulder\tT-0\n's\tO\nabsence\tO\nmeans\tO\nthat\tO\nNorthern\tB-ORG\nTransvaal\tI-ORG\ncentre\tO\nAndre\tO\nSnyman\tO\nshould\tT-1\nwin\tO\nhis\tO\nsecond\tO\ncap\tO\nalongside\tO\nprovincial\tO\ncolleague\tO\nDanie\tO\nvan\tO\nSchalkwyk\tO\n.\tO\n\nMulder\tT-0\n's\tT-0\nabsence\tO\nmeans\tO\nthat\tO\nNorthern\tT-2\nTransvaal\tT-2\ncentre\tO\nAndre\tB-PER\nSnyman\tI-PER\nshould\tO\nwin\tO\nhis\tO\nsecond\tO\ncap\tO\nalongside\tO\nprovincial\tT-3\ncolleague\tO\nDanie\tT-1\nvan\tT-1\nSchalkwyk\tT-1\n.\tO\n\nMulder\tT-2\n's\tO\nabsence\tT-0\nmeans\tO\nthat\tO\nNorthern\tO\nTransvaal\tO\ncentre\tO\nAndre\tT-3\nSnyman\tT-3\nshould\tO\nwin\tT-1\nhis\tO\nsecond\tO\ncap\tO\nalongside\tO\nprovincial\tO\ncolleague\tO\nDanie\tB-PER\nvan\tI-PER\nSchalkwyk\tI-PER\n.\tO\n\nWing\tT-0\nPieter\tB-PER\nHendriks\tI-PER\nis\tO\nexpected\tO\nto\tO\nretain\tO\nhis\tT-1\nplace\tO\n,\tO\nfollowing\tO\nspeculation\tO\nthat\tO\nSnyman\tO\nwould\tO\nbe\tO\npicked\tO\nout\tO\nof\tO\nposition\tO\non\tO\nthe\tO\nwing\tO\n.\tO\n\nWing\tO\nPieter\tO\nHendriks\tO\nis\tO\nexpected\tT-0\nto\tO\nretain\tO\nhis\tO\nplace\tO\n,\tO\nfollowing\tO\nspeculation\tO\nthat\tT-1\nSnyman\tB-PER\nwould\tO\nbe\tT-2\npicked\tT-2\nout\tT-2\nof\tT-2\nposition\tT-2\non\tO\nthe\tO\nwing\tO\n.\tO\n\nThe\tO\nline-up\tO\nwould\tO\nnot\tO\nbe\tO\nannounced\tT-1\nuntil\tO\nshortly\tO\nbefore\tO\nthe\tO\nstart\tT-2\n,\tO\nMarkgraaff\tB-PER\nsaid\tT-0\n.\tO\n\nBADMINTON\tT-0\n-\tO\nMALAYSIAN\tB-MISC\nOPEN\tI-MISC\nBADMINTON\tO\nRESULTS\tT-1\n.\tO\n\nResults\tT-0\nin\tT-0\nthe\tT-0\nMalaysian\tB-MISC\n\n2\tO\n-\tO\nOng\tB-PER\nEwe\tI-PER\nHock\tI-PER\n(\tO\nMalaysia\tT-0\n)\tO\nbeat\tT-2\n5/8\tO\n-\tO\nHu\tT-1\nZhilan\tT-1\n(\tO\nChina\tO\n)\tO\n15-2\tO\n15-10\tO\n\n2\tO\n-\tO\nOng\tT-0\nEwe\tT-0\nHock\tT-0\n(\tO\nMalaysia\tB-LOC\n)\tO\nbeat\tO\n5/8\tO\n-\tO\nHu\tO\nZhilan\tO\n(\tO\nChina\tO\n)\tO\n15-2\tO\n15-10\tO\n\n2\tO\n-\tO\nOng\tT-0\nEwe\tT-0\nHock\tT-0\n(\tO\nMalaysia\tO\n)\tO\nbeat\tT-1\n5/8\tO\n-\tO\nHu\tB-PER\nZhilan\tI-PER\n(\tO\nChina\tT-2\n)\tO\n15-2\tO\n15-10\tO\n\n2\tO\n-\tO\nOng\tO\nEwe\tO\nHock\tO\n(\tO\nMalaysia\tT-0\n)\tO\nbeat\tO\n5/8\tO\n-\tO\nHu\tO\nZhilan\tO\n(\tO\nChina\tB-LOC\n)\tO\n15-2\tO\n15-10\tO\n\n9/16\tO\n-\tO\nLuo\tB-PER\nYigang\tI-PER\n(\tO\nChina\tT-1\n)\tO\nbeat\tT-3\nJason\tT-0\nWong\tT-0\n(\tO\nMalaysia\tT-2\n)\tO\n15-5\tO\n15-6\tO\n\n9/16\tO\n-\tO\nLuo\tO\nYigang\tO\n(\tO\nChina\tT-0\n)\tO\nbeat\tT-2\nJason\tB-PER\nWong\tI-PER\n(\tO\nMalaysia\tT-1\n)\tO\n15-5\tO\n15-6\tO\n\n9/16\tO\n-\tO\nLuo\tO\nYigang\tO\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\nJason\tO\nWong\tO\n(\tO\nMalaysia\tB-LOC\n)\tO\n15-5\tO\n15-6\tO\n\nIjaya\tB-PER\nIndra\tI-PER\n(\tO\nIndonesia\tT-0\n)\tO\nbeat\tO\nP.\tO\nKantharoopan\tO\n(\tO\nMalaysia\tT-1\n)\tO\n15-6\tO\n5-4\tO\n\nIjaya\tT-0\nIndra\tT-0\n(\tO\nIndonesia\tB-LOC\n)\tO\nbeat\tO\nP.\tO\nKantharoopan\tT-1\n(\tO\nMalaysia\tO\n)\tO\n15-6\tO\n5-4\tO\n\nIjaya\tT-1\nIndra\tT-1\n(\tO\nIndonesia\tT-2\n)\tO\nbeat\tT-3\nP.\tB-PER\nKantharoopan\tI-PER\n(\tO\nMalaysia\tT-0\n)\tO\n15-6\tO\n5-4\tO\n\nIjaya\tT-0\nIndra\tT-0\n(\tO\nIndonesia\tO\n)\tO\nbeat\tT-1\nP.\tT-2\nKantharoopan\tT-2\n(\tO\nMalaysia\tB-LOC\n)\tO\n15-6\tO\n5-4\tO\n\n9/16\tO\n-\tO\nChen\tB-PER\nGang\tI-PER\n(\tO\nChina\tT-0\n)\tO\nbeat\tT-3\n9/16\tO\n-\tO\nHermawan\tT-1\nSusanto\tT-1\n(\tO\nIndonesia\tT-2\n)\tO\n\n9/16\tO\n-\tO\nChen\tT-1\nGang\tT-1\n(\tO\nChina\tB-LOC\n)\tO\nbeat\tT-0\n9/16\tO\n-\tO\nHermawan\tT-2\nSusanto\tT-2\n(\tO\nIndonesia\tT-3\n)\tO\n\n9/16\tO\n-\tO\nChen\tT-0\nGang\tT-0\n(\tO\nChina\tO\n)\tO\nbeat\tT-1\n9/16\tO\n-\tO\nHermawan\tB-PER\nSusanto\tI-PER\n(\tO\nIndonesia\tT-2\n)\tO\n\n9/16\tO\n-\tO\nChen\tO\nGang\tO\n(\tO\nChina\tO\n)\tO\nbeat\tT-0\n9/16\tT-0\n-\tT-0\nHermawan\tT-0\nSusanto\tT-0\n(\tO\nIndonesia\tB-LOC\n)\tO\n\nTENNIS\tO\n-\tO\nINJURED\tT-0\nCHANDA\tB-PER\nRUBIN\tI-PER\nOUT\tO\nOF\tO\nU.S.\tO\nOPEN\tO\n.\tO\n\nTENNIS\tT-0\n-\tO\nINJURED\tT-1\nCHANDA\tO\nRUBIN\tO\nOUT\tO\nOF\tO\nU.S.\tB-MISC\nOPEN\tI-MISC\n.\tO\n\nPromising\tO\n10th-ranked\tT-0\nAmerican\tB-MISC\nChanda\tT-2\nRubin\tT-2\nhas\tO\npulled\tO\nout\tO\nof\tO\nthe\tO\nU.S.\tT-1\nOpen\tT-1\nTennis\tO\nChampionships\tO\nwith\tO\na\tO\nwrist\tO\ninjury\tO\n,\tO\ntournament\tO\nofficials\tO\nannounced\tO\n.\tO\n\nPromising\tO\n10th-ranked\tO\nAmerican\tT-1\nChanda\tB-PER\nRubin\tI-PER\nhas\tO\npulled\tO\nout\tO\nof\tO\nthe\tO\nU.S.\tO\nOpen\tO\nTennis\tO\nChampionships\tT-0\nwith\tO\na\tO\nwrist\tO\ninjury\tT-2\n,\tO\ntournament\tO\nofficials\tO\nannounced\tO\n.\tO\n\nPromising\tO\n10th-ranked\tO\nAmerican\tO\nChanda\tO\nRubin\tO\nhas\tO\npulled\tT-1\nout\tO\nof\tO\nthe\tO\nU.S.\tB-MISC\nOpen\tI-MISC\nTennis\tI-MISC\nChampionships\tI-MISC\nwith\tO\na\tO\nwrist\tT-0\ninjury\tT-0\n,\tO\ntournament\tT-2\nofficials\tO\nannounced\tO\n.\tO\n\nThe\tT-3\n20-year-old\tT-3\nRubin\tB-PER\n,\tO\nwho\tO\nwas\tO\nto\tO\nbe\tO\nseeded\tT-1\n11th\tO\n,\tO\nis\tO\nstill\tO\nsuffering\tT-2\nfrom\tO\ntendinitis\tT-4\nof\tO\nthe\tO\nright\tO\nwrist\tT-0\nthat\tO\nhas\tO\nkept\tO\nher\tO\nsidelined\tO\nin\tO\nrecent\tO\nmonths\tO\n.\tO\n\nRubin\tB-PER\n's\tO\nmisfortune\tO\nturned\tT-1\ninto\tO\na\tO\nvery\tO\nlucky\tO\nbreak\tO\nfor\tO\neighth-seeded\tO\nOlympic\tT-0\nchampion\tT-0\nLindsay\tT-2\nDavenport\tT-2\n.\tO\n\nRubin\tO\n's\tO\nmisfortune\tT-2\nturned\tO\ninto\tO\na\tO\nvery\tO\nlucky\tO\nbreak\tO\nfor\tO\neighth-seeded\tT-0\nOlympic\tB-MISC\nchampion\tT-1\nLindsay\tO\nDavenport\tO\n.\tO\n\nRubin\tO\n's\tO\nmisfortune\tO\nturned\tT-1\ninto\tO\na\tO\nvery\tO\nlucky\tO\nbreak\tO\nfor\tO\neighth-seeded\tO\nOlympic\tO\nchampion\tT-0\nLindsay\tB-PER\nDavenport\tI-PER\n.\tO\n\nDavenport\tB-PER\nhad\tO\ndrawn\tO\none\tO\nof\tO\nthe\tO\ntoughest\tO\nfirst-round\tO\nassignments\tO\nof\tO\nany\tO\nof\tO\nthe\tO\nseeded\tT-0\nplayers\tT-1\nin\tO\n17th-ranked\tO\nKarina\tO\nHabsudova\tO\nof\tO\nSlovakia\tO\n.\tO\n\nDavenport\tT-1\nhad\tO\ndrawn\tO\none\tO\nof\tO\nthe\tO\ntoughest\tO\nfirst-round\tO\nassignments\tT-0\nof\tO\nany\tO\nof\tO\nthe\tO\nseeded\tO\nplayers\tT-2\nin\tO\n17th-ranked\tO\nKarina\tB-PER\nHabsudova\tI-PER\nof\tO\nSlovakia\tO\n.\tO\n\nDavenport\tO\nhad\tO\ndrawn\tO\none\tO\nof\tO\nthe\tO\ntoughest\tO\nfirst-round\tO\nassignments\tO\nof\tO\nany\tO\nof\tO\nthe\tO\nseeded\tT-2\nplayers\tO\nin\tT-0\n17th-ranked\tO\nKarina\tO\nHabsudova\tT-3\nof\tT-1\nSlovakia\tB-LOC\n.\tO\n\nBut\tO\nas\tO\nthe\tO\nhighest-ranked\tO\nnon-seeded\tO\nplayer\tT-0\nin\tO\nthe\tO\ntournament\tO\n,\tO\nHabsudova\tB-PER\nwill\tO\nbe\tO\nmoved\tO\ninto\tO\nRubin\tO\n's\tO\nslot\tO\nin\tO\nthe\tO\ndraw\tO\n,\tO\nwhile\tO\nDavenport\tO\nwill\tO\nnow\tO\nget\tO\na\tO\nqualifier\tO\nin\tO\nthe\tO\nfirst\tO\nround\tO\n,\tO\naccording\tO\nto\tO\nU.S.\tO\nTennis\tO\nAssociation\tO\nofficials\tO\n.\tO\n\nBut\tO\nas\tO\nthe\tO\nhighest-ranked\tO\nnon-seeded\tO\nplayer\tO\nin\tO\nthe\tO\ntournament\tO\n,\tO\nHabsudova\tO\nwill\tO\nbe\tO\nmoved\tT-2\ninto\tO\nRubin\tB-PER\n's\tT-1\nslot\tT-0\nin\tO\nthe\tO\ndraw\tO\n,\tO\nwhile\tO\nDavenport\tO\nwill\tO\nnow\tO\nget\tO\na\tO\nqualifier\tO\nin\tO\nthe\tO\nfirst\tO\nround\tO\n,\tO\naccording\tO\nto\tO\nU.S.\tO\nTennis\tO\nAssociation\tO\nofficials\tO\n.\tO\n\nBut\tO\nas\tO\nthe\tO\nhighest-ranked\tO\nnon-seeded\tO\nplayer\tO\nin\tO\nthe\tO\ntournament\tO\n,\tO\nHabsudova\tO\nwill\tO\nbe\tO\nmoved\tO\ninto\tO\nRubin\tT-1\n's\tO\nslot\tO\nin\tO\nthe\tO\ndraw\tO\n,\tO\nwhile\tO\nDavenport\tB-PER\nwill\tT-0\nnow\tO\nget\tO\na\tO\nqualifier\tO\nin\tO\nthe\tO\nfirst\tO\nround\tO\n,\tO\naccording\tO\nto\tO\nU.S.\tO\nTennis\tO\nAssociation\tO\nofficials\tO\n.\tO\n\nBut\tO\nas\tO\nthe\tO\nhighest-ranked\tO\nnon-seeded\tO\nplayer\tO\nin\tO\nthe\tO\ntournament\tO\n,\tO\nHabsudova\tO\nwill\tO\nbe\tO\nmoved\tO\ninto\tO\nRubin\tT-2\n's\tO\nslot\tO\nin\tO\nthe\tO\ndraw\tO\n,\tO\nwhile\tO\nDavenport\tT-3\nwill\tO\nnow\tO\nget\tO\na\tO\nqualifier\tO\nin\tO\nthe\tO\nfirst\tO\nround\tO\n,\tO\naccording\tT-0\nto\tT-0\nU.S.\tB-MISC\nTennis\tI-MISC\nAssociation\tI-MISC\nofficials\tT-1\n.\tO\n\nRubin\tB-PER\nis\tT-5\nthe\tT-5\nthird\tO\nnotable\tO\nwithdrawal\tO\nfrom\tO\nthe\tO\nwomen\tT-0\n's\tT-0\ncompetition\tO\nafter\tO\n12th-ranked\tO\nformer\tO\nAustralian\tO\nOpen\tO\nchampion\tO\nMary\tT-3\nPierce\tT-3\nand\tO\n20th-ranked\tO\nWimbledon\tT-1\nsemifinalist\tO\nMeredith\tT-4\nMcGrath\tT-4\npulled\tO\nout\tO\nearlier\tO\nthis\tO\nweek\tO\nwith\tO\ninjuries\tT-2\n.\tO\n\nRubin\tO\nis\tO\nthe\tO\nthird\tO\nnotable\tO\nwithdrawal\tO\nfrom\tO\nthe\tO\nwomen\tO\n's\tO\ncompetition\tO\nafter\tO\n12th-ranked\tO\nformer\tO\nAustralian\tB-MISC\nOpen\tI-MISC\nchampion\tT-0\nMary\tO\nPierce\tO\nand\tO\n20th-ranked\tO\nWimbledon\tO\nsemifinalist\tO\nMeredith\tO\nMcGrath\tO\npulled\tO\nout\tO\nearlier\tO\nthis\tO\nweek\tO\nwith\tO\ninjuries\tO\n.\tO\n\nRubin\tO\nis\tO\nthe\tO\nthird\tO\nnotable\tO\nwithdrawal\tO\nfrom\tO\nthe\tO\nwomen\tT-1\n's\tT-1\ncompetition\tT-1\nafter\tO\n12th-ranked\tO\nformer\tO\nAustralian\tO\nOpen\tO\nchampion\tT-0\nMary\tB-PER\nPierce\tI-PER\nand\tO\n20th-ranked\tT-2\nWimbledon\tO\nsemifinalist\tO\nMeredith\tO\nMcGrath\tO\npulled\tT-3\nout\tT-3\nearlier\tO\nthis\tO\nweek\tO\nwith\tO\ninjuries\tO\n.\tO\n\nRubin\tO\nis\tO\nthe\tO\nthird\tO\nnotable\tO\nwithdrawal\tT-0\nfrom\tO\nthe\tO\nwomen\tO\n's\tO\ncompetition\tT-1\nafter\tO\n12th-ranked\tO\nformer\tO\nAustralian\tT-2\nOpen\tT-2\nchampion\tT-2\nMary\tO\nPierce\tO\nand\tO\n20th-ranked\tO\nWimbledon\tB-MISC\nsemifinalist\tO\nMeredith\tO\nMcGrath\tO\npulled\tO\nout\tO\nearlier\tO\nthis\tO\nweek\tO\nwith\tO\ninjuries\tO\n.\tO\n\nRubin\tO\nis\tO\nthe\tO\nthird\tO\nnotable\tO\nwithdrawal\tT-1\nfrom\tO\nthe\tO\nwomen\tT-2\n's\tT-2\ncompetition\tT-2\nafter\tO\n12th-ranked\tO\nformer\tO\nAustralian\tT-0\nOpen\tT-0\nchampion\tT-0\nMary\tO\nPierce\tO\nand\tO\n20th-ranked\tO\nWimbledon\tO\nsemifinalist\tO\nMeredith\tB-PER\nMcGrath\tI-PER\npulled\tO\nout\tO\nearlier\tO\nthis\tO\nweek\tO\nwith\tO\ninjuries\tO\n.\tO\n\nMen\tO\n's\tO\nAustralian\tB-MISC\nOpen\tI-MISC\nchampion\tT-0\nBoris\tO\nBecker\tO\nwill\tO\nalso\tO\nmiss\tT-1\nthe\tO\nyear\tO\n's\tO\nfinal\tT-2\nGrand\tT-2\nSlam\tT-2\nwith\tO\na\tO\nwrist\tO\ninjury\tO\n.\tO\n\nMen\tO\n's\tO\nAustralian\tO\nOpen\tO\nchampion\tO\nBoris\tB-PER\nBecker\tI-PER\nwill\tO\nalso\tO\nmiss\tO\nthe\tO\nyear\tO\n's\tO\nfinal\tO\nGrand\tT-0\nSlam\tT-0\nwith\tO\na\tO\nwrist\tO\ninjury\tO\n.\tO\n\nMen\tO\n's\tO\nAustralian\tT-1\nOpen\tT-1\nchampion\tO\nBoris\tT-4\nBecker\tT-4\nwill\tO\nalso\tO\nmiss\tT-2\nthe\tO\nyear\tT-0\n's\tT-0\nfinal\tT-0\nGrand\tB-MISC\nSlam\tI-MISC\nwith\tO\na\tO\nwrist\tO\ninjury\tT-3\n.\tO\n\nBASEBALL\tT-0\n-\tO\nMAJOR\tB-MISC\nLEAGUE\tI-MISC\nSTANDINGS\tT-1\nAFTER\tO\nTHURSDAY\tT-2\n'S\tO\nGAMES\tO\n.\tO\n\nTORONTO\tB-ORG\n59\tT-0\n69\tT-0\n.461\tT-0\n14\tT-0\n\nDETROIT\tB-ORG\n45\tO\n82\tO\n.354\tO\n27\tO\n1/2\tT-0\n\nCLEVELAND\tB-ORG\n76\tT-0\n51\tT-0\n.598\tT-0\n-\tT-0\n\nMINNESOTA\tB-ORG\n63\tT-0\n64\tO\n.496\tO\n13\tO\n\nTEXAS\tB-ORG\n74\tT-0\n54\tT-0\n.578\tT-0\n-\tO\n\nCALIFORNIA\tB-ORG\n59\tT-0\n68\tO\n.465\tO\n14\tO\n1/2\tO\n\nSEATTLE\tB-ORG\nAT\tO\nBOSTON\tT-0\n\nSEATTLE\tT-0\nAT\tO\nBOSTON\tB-LOC\n\nMILWAUKEE\tB-ORG\nAT\tT-0\nCLEVELAND\tO\n\nMILWAUKEE\tT-0\nAT\tT-1\nCLEVELAND\tB-LOC\n\nCALIFORNIA\tB-ORG\nAT\tT-0\nBALTIMORE\tO\n\nCALIFORNIA\tT-0\nAT\tO\nBALTIMORE\tB-LOC\n\nOAKLAND\tB-ORG\nAT\tT-0\nNEW\tT-1\nYORK\tT-1\n\nOAKLAND\tT-0\nAT\tO\nNEW\tB-LOC\nYORK\tI-LOC\n\nTORONTO\tT-0\nAT\tT-1\nCHICAGO\tB-LOC\n\nDETROIT\tB-ORG\nAT\tO\nKANSAS\tT-0\nCITY\tO\n\nDETROIT\tO\nAT\tT-0\nKANSAS\tB-LOC\nCITY\tI-LOC\n\nTEXAS\tB-ORG\nAT\tT-0\nMINNESOTA\tO\n\nTEXAS\tT-0\nAT\tT-0\nMINNESOTA\tB-LOC\n\nMONTREAL\tB-ORG\n68\tT-0\n58\tT-0\n.540\tT-0\n11\tT-0\n\nFLORIDA\tB-ORG\n58\tT-0\n69\tO\n.457\tO\n21\tO\n1/2\tT-1\n\nLOS\tB-ORG\nANGELES\tI-ORG\n67\tT-0\n60\tO\n.528\tO\n2\tO\n\nCOLORADO\tB-ORG\n66\tT-0\n62\tT-0\n.516\tT-0\n3\tT-0\n1/2\tT-0\n\nCINCINNATI\tB-ORG\nAT\tT-0\nFLORIDA\tT-1\n(\tO\ndoubleheader\tO\n)\tO\n\nCINCINNATI\tT-0\nAT\tO\nFLORIDA\tB-LOC\n(\tO\ndoubleheader\tT-1\n)\tO\n\nCHICAGO\tB-ORG\nAT\tT-0\nATLANTA\tO\n\nCHICAGO\tT-0\nAT\tO\nATLANTA\tB-LOC\n\nST\tB-ORG\nLOUIS\tI-ORG\nAT\tT-0\nHOUSTON\tT-1\n\nST\tT-0\nLOUIS\tT-0\nAT\tT-1\nHOUSTON\tB-LOC\n\nPITTSBURGH\tT-0\nAT\tO\nCOLORADO\tB-LOC\n\nNEW\tB-ORG\nYORK\tI-ORG\nAT\tT-0\nLOS\tT-1\nANGELES\tT-1\n\nNEW\tT-0\nYORK\tT-0\nAT\tT-1\nLOS\tB-LOC\nANGELES\tI-LOC\n\nPHILADELPHIA\tB-ORG\nAT\tT-1\nSAN\tO\nDIEGO\tO\n\nPHILADELPHIA\tT-0\nAT\tT-1\nSAN\tB-LOC\nDIEGO\tI-LOC\n\nMONTREAL\tB-ORG\nAT\tO\nSAN\tO\nFRANCISCO\tT-0\n\nBASEBALL\tO\n-\tO\nMAJOR\tB-MISC\nLEAGUE\tI-MISC\nRESULTS\tT-0\nTHURSDAY\tO\n.\tO\n\nResults\tT-0\nof\tO\nMajor\tB-MISC\nLeague\tI-MISC\n\nBOSTON\tB-ORG\n2\tO\nOakland\tT-0\n1\tO\n\nBOSTON\tT-0\n2\tO\nOakland\tB-ORG\n1\tO\n\nSeattle\tB-ORG\n10\tT-0\nBALTIMORE\tT-1\n3\tO\n\nSeattle\tT-0\n10\tO\nBALTIMORE\tB-ORG\n3\tO\n\nToronto\tB-ORG\n1\tO\nCHICAGO\tT-0\n0\tO\n(\tO\nin\tO\n6\tO\n1/2\tO\n)\tO\n\nToronto\tT-0\n1\tO\nCHICAGO\tB-ORG\n0\tO\n(\tO\nin\tO\n6\tO\n1/2\tO\n)\tO\n\nDetroit\tB-ORG\n10\tT-1\nKANSAS\tT-2\nCITY\tT-2\n3\tT-0\n\nDetroit\tT-0\n10\tO\nKANSAS\tB-ORG\nCITY\tI-ORG\n3\tT-1\n\nTexas\tB-ORG\n11\tO\nMINNESOTA\tT-0\n2\tO\n\nTexas\tO\n11\tO\nMINNESOTA\tB-ORG\n2\tT-0\n\nCOLORADO\tB-ORG\n10\tO\nSt\tT-0\nLouis\tT-0\n5\tO\n\nCOLORADO\tT-0\n10\tO\nSt\tB-ORG\nLouis\tI-ORG\n5\tO\n\nCincinnati\tB-ORG\n3\tT-1\nATLANTA\tT-0\n2\tO\n(\tO\nin\tO\n13\tO\n)\tO\n\nCincinnati\tT-0\n3\tO\nATLANTA\tB-ORG\n2\tO\n(\tO\nin\tO\n13\tO\n)\tO\n\nPittsburgh\tB-ORG\n8\tT-0\nHOUSTON\tO\n6\tT-1\n\nLOS\tB-ORG\nANGELES\tI-ORG\n8\tO\nPhiladelphia\tT-0\n5\tO\n\nLOS\tO\nANGELES\tO\n8\tO\nPhiladelphia\tB-ORG\n5\tT-0\n\nMontreal\tB-ORG\n5\tT-0\nSAN\tT-0\nFRANCISCO\tT-0\n4\tT-0\n\nMontreal\tT-0\n5\tO\nSAN\tB-ORG\nFRANCISCO\tI-ORG\n4\tO\n\nBASEBALL\tO\n-\tO\nSORRENTO\tB-PER\nHITS\tO\nSLAM\tO\nAS\tO\nSEATTLE\tT-0\nROUTS\tO\nORIOLES\tT-1\n.\tO\n\nBASEBALL\tT-0\n-\tO\nSORRENTO\tT-3\nHITS\tO\nSLAM\tT-1\nAS\tO\nSEATTLE\tB-ORG\nROUTS\tT-2\nORIOLES\tO\n.\tO\n\nBASEBALL\tO\n-\tO\nSORRENTO\tO\nHITS\tT-0\nSLAM\tT-1\nAS\tO\nSEATTLE\tO\nROUTS\tT-2\nORIOLES\tB-ORG\n.\tO\n\nFormer\tO\nOriole\tB-MISC\nJamie\tT-1\nMoyer\tT-1\nallowed\tT-0\ntwo\tO\nhits\tO\nover\tO\neight\tO\nscoreless\tO\ninnings\tO\nbefore\tO\ntiring\tO\nin\tO\nthe\tO\nninth\tO\nand\tO\nPaul\tO\nSorrento\tO\nadded\tO\nhis\tO\nthird\tO\ngrand\tO\nslam\tO\nof\tO\nthe\tO\nseason\tO\nas\tO\nthe\tO\nSeattle\tO\nMariners\tO\nrouted\tO\nBaltimore\tO\n10-3\tO\nThursday\tO\n.\tO\n\nFormer\tO\nOriole\tO\nJamie\tB-PER\nMoyer\tI-PER\nallowed\tO\ntwo\tO\nhits\tO\nover\tO\neight\tO\nscoreless\tT-0\ninnings\tO\nbefore\tO\ntiring\tO\nin\tO\nthe\tO\nninth\tO\nand\tO\nPaul\tO\nSorrento\tO\nadded\tO\nhis\tO\nthird\tO\ngrand\tO\nslam\tO\nof\tO\nthe\tO\nseason\tO\nas\tO\nthe\tO\nSeattle\tO\nMariners\tO\nrouted\tO\nBaltimore\tO\n10-3\tO\nThursday\tO\n.\tO\n\nFormer\tO\nOriole\tO\nJamie\tO\nMoyer\tO\nallowed\tT-1\ntwo\tO\nhits\tO\nover\tO\neight\tO\nscoreless\tO\ninnings\tO\nbefore\tO\ntiring\tO\nin\tO\nthe\tO\nninth\tT-0\nand\tO\nPaul\tB-PER\nSorrento\tI-PER\nadded\tT-2\nhis\tT-2\nthird\tT-2\ngrand\tT-2\nslam\tT-2\nof\tO\nthe\tO\nseason\tO\nas\tO\nthe\tO\nSeattle\tO\nMariners\tO\nrouted\tO\nBaltimore\tO\n10-3\tO\nThursday\tO\n.\tO\n\nFormer\tT-3\nOriole\tO\nJamie\tT-0\nMoyer\tT-0\nallowed\tT-4\ntwo\tO\nhits\tO\nover\tO\neight\tT-1\nscoreless\tT-1\ninnings\tT-1\nbefore\tO\ntiring\tO\nin\tO\nthe\tO\nninth\tO\nand\tO\nPaul\tO\nSorrento\tO\nadded\tO\nhis\tO\nthird\tT-2\ngrand\tT-2\nslam\tT-2\nof\tO\nthe\tO\nseason\tO\nas\tO\nthe\tO\nSeattle\tB-ORG\nMariners\tI-ORG\nrouted\tO\nBaltimore\tO\n10-3\tO\nThursday\tO\n.\tO\n\nFormer\tO\nOriole\tO\nJamie\tO\nMoyer\tO\nallowed\tO\ntwo\tO\nhits\tO\nover\tO\neight\tO\nscoreless\tO\ninnings\tO\nbefore\tO\ntiring\tO\nin\tO\nthe\tO\nninth\tO\nand\tO\nPaul\tO\nSorrento\tO\nadded\tO\nhis\tO\nthird\tO\ngrand\tO\nslam\tO\nof\tO\nthe\tO\nseason\tO\nas\tO\nthe\tO\nSeattle\tT-1\nMariners\tT-1\nrouted\tT-0\nBaltimore\tB-ORG\n10-3\tO\nThursday\tO\n.\tO\n\nMoyer\tB-PER\n(\tO\n10-2\tO\n)\tO\n,\tO\nwho\tT-0\nwas\tO\ntagged\tO\nfor\tO\na\tO\npair\tO\nof\tO\nhomers\tO\nby\tO\nMike\tO\nDevereaux\tO\nand\tO\nBrady\tO\nAnderson\tO\nand\tO\nthree\tO\nruns\tO\nin\tO\nthe\tO\nninth\tO\n,\tO\nwalked\tT-1\nnone\tO\nand\tO\nstruck\tO\nout\tO\ntwo\tO\n.\tO\n\nMoyer\tT-1\n(\tO\n10-2\tO\n)\tO\n,\tO\nwho\tO\nwas\tO\ntagged\tT-2\nfor\tO\na\tO\npair\tO\nof\tO\nhomers\tT-0\nby\tO\nMike\tB-PER\nDevereaux\tI-PER\nand\tO\nBrady\tO\nAnderson\tO\nand\tO\nthree\tO\nruns\tO\nin\tO\nthe\tO\nninth\tO\n,\tO\nwalked\tT-3\nnone\tO\nand\tO\nstruck\tO\nout\tO\ntwo\tO\n.\tO\n\nMoyer\tO\n(\tO\n10-2\tO\n)\tO\n,\tO\nwho\tO\nwas\tO\ntagged\tO\nfor\tO\na\tO\npair\tO\nof\tO\nhomers\tO\nby\tO\nMike\tT-1\nDevereaux\tT-1\nand\tT-1\nBrady\tB-PER\nAnderson\tI-PER\nand\tO\nthree\tO\nruns\tO\nin\tO\nthe\tO\nninth\tO\n,\tO\nwalked\tT-0\nnone\tO\nand\tO\nstruck\tO\nout\tO\ntwo\tO\n.\tO\n\nNorm\tB-PER\nCharlton\tI-PER\nretired\tT-0\nthe\tO\nfinal\tO\nthree\tO\nbatters\tT-1\nto\tO\nseal\tO\nthe\tO\nvictory\tO\n.\tO\n\nWith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nfifth\tO\nKen\tB-PER\nGriffey\tI-PER\nJr\tI-PER\nand\tT-0\nEdgar\tO\nMartinez\tO\nstroked\tT-1\nback-to-back\tT-1\nsingles\tT-1\noff\tT-1\nOrioles\tO\nstarter\tO\nRocky\tO\nCoppinger\tO\n(\tO\n7-5\tO\n)\tO\nand\tO\nJay\tO\nBuhner\tO\nwalked\tO\n.\tO\n\nWith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nfifth\tO\nKen\tT-1\nGriffey\tT-1\nJr\tT-2\nand\tO\nEdgar\tB-PER\nMartinez\tI-PER\nstroked\tT-0\nback-to-back\tT-0\nsingles\tT-0\noff\tO\nOrioles\tO\nstarter\tO\nRocky\tO\nCoppinger\tO\n(\tO\n7-5\tO\n)\tO\nand\tO\nJay\tT-3\nBuhner\tT-3\nwalked\tO\n.\tO\n\nWith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nfifth\tO\nKen\tO\nGriffey\tO\nJr\tO\nand\tO\nEdgar\tO\nMartinez\tO\nstroked\tO\nback-to-back\tO\nsingles\tO\noff\tO\nOrioles\tB-ORG\nstarter\tT-0\nRocky\tO\nCoppinger\tO\n(\tO\n7-5\tO\n)\tO\nand\tO\nJay\tO\nBuhner\tO\nwalked\tT-1\n.\tO\n\nWith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nfifth\tO\nKen\tT-2\nGriffey\tT-2\nJr\tT-2\nand\tO\nEdgar\tT-3\nMartinez\tT-3\nstroked\tO\nback-to-back\tO\nsingles\tO\noff\tO\nOrioles\tO\nstarter\tT-1\nRocky\tB-PER\nCoppinger\tI-PER\n(\tO\n7-5\tO\n)\tO\nand\tT-0\nJay\tO\nBuhner\tO\nwalked\tO\n.\tO\n\nWith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nfifth\tO\nKen\tO\nGriffey\tO\nJr\tO\nand\tO\nEdgar\tO\nMartinez\tO\nstroked\tO\nback-to-back\tO\nsingles\tO\noff\tO\nOrioles\tT-0\nstarter\tO\nRocky\tT-2\nCoppinger\tT-2\n(\tO\n7-5\tO\n)\tO\nand\tO\nJay\tB-PER\nBuhner\tI-PER\nwalked\tT-1\n.\tO\n\nSorrento\tB-PER\nfollowed\tO\nby\tO\nhitting\tT-1\na\tO\n1-2\tO\npitch\tT-2\njust\tO\nover\tO\nthe\tO\nright-field\tO\nwall\tO\nfor\tO\na\tO\n7-0\tO\nadvantage\tT-0\n.\tO\n\nRight\tT-1\nfielder\tT-1\nBobby\tB-PER\nBonilla\tI-PER\nwas\tO\nafter\tO\nthe\tO\nball\tT-0\n,\tO\nwhich\tO\nwas\tO\ntouched\tO\nby\tO\nfans\tO\nat\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nscoreboard\tO\nin\tO\nright\tO\n.\tO\n\n\"\tO\nThings\tO\nfell\tO\nin\tO\nfor\tO\nus\tO\n,\tO\n\"\tO\nsaid\tT-2\nSorrento\tB-PER\n,\tO\nwho\tO\nhas\tO\nsix\tO\ncareer\tO\ngrand\tT-0\nslams\tT-1\nand\tO\nhit\tO\nthe\tO\nninth\tO\nof\tO\nthe\tO\nseason\tO\nfor\tO\nthe\tO\nMariners\tO\n.\tO\n\n\"\tO\nThings\tO\nfell\tO\nin\tO\nfor\tO\nus\tO\n,\tO\n\"\tO\nsaid\tT-2\nSorrento\tT-2\n,\tO\nwho\tO\nhas\tO\nsix\tT-3\ncareer\tT-3\ngrand\tT-4\nslams\tT-4\nand\tO\nhit\tO\nthe\tO\nninth\tO\nof\tO\nthe\tO\nseason\tT-0\nfor\tO\nthe\tO\nMariners\tB-ORG\n.\tO\n\nIn\tO\nthe\tO\nAmerican\tB-MISC\nLeague\tI-MISC\nwild-card\tT-0\nrace\tT-0\n,\tT-0\nthe\tO\nMariners\tT-2\nare\tO\nthree\tO\ngames\tO\nbehind\tO\nthe\tO\nWhite\tO\nSox\tO\n,\tO\ntwo\tO\nbehind\tO\nBaltimore\tT-1\nand\tO\ntwo\tO\nahead\tO\nof\tO\nthe\tO\nRed\tO\nSox\tO\nheading\tO\ninto\tO\nBoston\tO\nfor\tO\na\tO\nweekend\tO\nseries\tO\n.\tO\n\nIn\tO\nthe\tO\nAmerican\tT-1\nLeague\tT-1\nwild-card\tO\nrace\tO\n,\tO\nthe\tT-0\nMariners\tB-ORG\nare\tO\nthree\tO\ngames\tO\nbehind\tO\nthe\tO\nWhite\tT-2\nSox\tT-2\n,\tO\ntwo\tO\nbehind\tO\nBaltimore\tO\nand\tO\ntwo\tO\nahead\tO\nof\tO\nthe\tO\nRed\tT-3\nSox\tT-3\nheading\tO\ninto\tO\nBoston\tO\nfor\tO\na\tO\nweekend\tO\nseries\tO\n.\tO\n\nIn\tO\nthe\tO\nAmerican\tO\nLeague\tO\nwild-card\tO\nrace\tO\n,\tO\nthe\tO\nMariners\tO\nare\tO\nthree\tO\ngames\tO\nbehind\tO\nthe\tO\nWhite\tB-ORG\nSox\tI-ORG\n,\tO\ntwo\tO\nbehind\tO\nBaltimore\tO\nand\tO\ntwo\tO\nahead\tT-0\nof\tO\nthe\tO\nRed\tO\nSox\tO\nheading\tT-1\ninto\tO\nBoston\tO\nfor\tO\na\tO\nweekend\tO\nseries\tO\n.\tO\n\nIn\tO\nthe\tO\nAmerican\tO\nLeague\tO\nwild-card\tO\nrace\tO\n,\tO\nthe\tO\nMariners\tO\nare\tO\nthree\tT-2\ngames\tT-2\nbehind\tO\nthe\tO\nWhite\tO\nSox\tO\n,\tO\ntwo\tO\nbehind\tT-3\nBaltimore\tB-ORG\nand\tO\ntwo\tT-0\nahead\tT-1\nof\tO\nthe\tO\nRed\tO\nSox\tO\nheading\tO\ninto\tO\nBoston\tO\nfor\tO\na\tO\nweekend\tO\nseries\tO\n.\tO\n\nIn\tO\nthe\tO\nAmerican\tO\nLeague\tO\nwild-card\tO\nrace\tO\n,\tO\nthe\tO\nMariners\tT-1\nare\tO\nthree\tO\ngames\tO\nbehind\tO\nthe\tO\nWhite\tO\nSox\tO\n,\tO\ntwo\tO\nbehind\tO\nBaltimore\tO\nand\tO\ntwo\tO\nahead\tO\nof\tO\nthe\tT-0\nRed\tB-ORG\nSox\tI-ORG\nheading\tT-2\ninto\tO\nBoston\tO\nfor\tO\na\tO\nweekend\tO\nseries\tO\n.\tO\n\nIn\tO\nthe\tO\nAmerican\tO\nLeague\tO\nwild-card\tO\nrace\tO\n,\tO\nthe\tO\nMariners\tO\nare\tO\nthree\tO\ngames\tO\nbehind\tO\nthe\tO\nWhite\tO\nSox\tO\n,\tO\ntwo\tO\nbehind\tO\nBaltimore\tO\nand\tO\ntwo\tO\nahead\tO\nof\tO\nthe\tO\nRed\tO\nSox\tO\nheading\tT-0\ninto\tO\nBoston\tB-LOC\nfor\tT-1\na\tT-1\nweekend\tT-1\nseries\tT-1\n.\tO\n\nMoyer\tB-PER\nretired\tT-0\n11\tO\nstraight\tO\nbatters\tO\nbetween\tO\nthe\tO\nthird\tO\nand\tO\nseventh\tO\ninnings\tO\nand\tO\nthrew\tO\ntwo\tO\nor\tO\nfewer\tO\npitches\tO\nto\tO\n11\tO\nof\tO\nthe\tO\n29\tO\nbatters\tO\nhe\tO\nfaced\tO\n.\tO\n\nWe\tT-0\nwon\tT-1\nthe\tO\ngame\tT-2\n,\tO\n\"\tO\nsaid\tO\nMoyer\tB-PER\n.\tO\n\nCoppinger\tB-PER\n(\tO\n7-5\tO\n)\tO\nwas\tT-0\ntagged\tT-0\nfor\tO\neight\tO\nruns\tO\nand\tO\n10\tO\nhits\tO\nin\tO\n4\tO\n1/3\tO\ninnings\tO\n.\tO\n\nOrioles\tB-ORG\nmanager\tT-1\nDavey\tO\nJohnson\tO\nmissed\tO\nthe\tO\ngame\tT-0\nafter\tO\nbeing\tO\nadmitted\tO\nto\tO\na\tO\nhospital\tO\nwith\tO\nan\tO\nirregular\tO\nheartbeat\tO\n.\tO\n\nOrioles\tT-0\nmanager\tT-0\nDavey\tB-PER\nJohnson\tI-PER\nmissed\tT-1\nthe\tO\ngame\tO\nafter\tO\nbeing\tO\nadmitted\tO\nto\tO\na\tO\nhospital\tO\nwith\tO\nan\tO\nirregular\tO\nheartbeat\tO\n.\tO\n\nBench\tO\ncoach\tT-0\nAndy\tB-PER\nEtchebarren\tI-PER\ntook\tO\nhis\tO\nplace\tO\n.\tO\n\nIn\tO\nBoston\tB-LOC\n,\tO\nTroy\tT-0\nO'Leary\tT-0\nhomered\tO\noff\tO\nthe\tO\nright-field\tO\nfoul\tO\npole\tO\nwith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\nninth\tO\nand\tO\nthe\tO\nRed\tT-1\nSox\tT-1\nclimbed\tO\nto\tO\nthe\tO\n.500\tO\nmark\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nthis\tO\nseason\tO\nwith\tO\ntheir\tO\nfourth\tO\nstraight\tO\nvictory\tO\n,\tO\n2-1\tO\nover\tO\nthe\tO\nOakland\tT-2\nAthletics\tT-2\n.\tO\n\nIn\tO\nBoston\tT-3\n,\tO\nTroy\tB-PER\nO'Leary\tI-PER\nhomered\tT-2\noff\tO\nthe\tO\nright-field\tO\nfoul\tO\npole\tO\nwith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\nninth\tO\nand\tO\nthe\tO\nRed\tO\nSox\tO\nclimbed\tT-0\nto\tO\nthe\tO\n.500\tO\nmark\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nthis\tO\nseason\tO\nwith\tO\ntheir\tO\nfourth\tO\nstraight\tO\nvictory\tT-1\n,\tO\n2-1\tO\nover\tO\nthe\tO\nOakland\tO\nAthletics\tO\n.\tO\n\nIn\tO\nBoston\tO\n,\tO\nTroy\tT-2\nO'Leary\tT-3\nhomered\tT-0\noff\tO\nthe\tO\nright-field\tO\nfoul\tO\npole\tO\nwith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\nninth\tO\nand\tO\nthe\tO\nRed\tB-ORG\nSox\tI-ORG\nclimbed\tO\nto\tO\nthe\tO\n.500\tO\nmark\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nthis\tO\nseason\tO\nwith\tO\ntheir\tO\nfourth\tO\nstraight\tO\nvictory\tT-1\n,\tO\n2-1\tO\nover\tO\nthe\tO\nOakland\tO\nAthletics\tO\n.\tO\n\nIn\tO\nBoston\tT-0\n,\tO\nTroy\tT-1\nO'Leary\tT-1\nhomered\tT-3\noff\tO\nthe\tO\nright-field\tO\nfoul\tO\npole\tO\nwith\tO\none\tO\nout\tO\nin\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\nninth\tO\nand\tO\nthe\tO\nRed\tO\nSox\tO\nclimbed\tO\nto\tO\nthe\tO\n.500\tO\nmark\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nthis\tO\nseason\tO\nwith\tO\ntheir\tO\nfourth\tO\nstraight\tO\nvictory\tT-2\n,\tO\n2-1\tO\nover\tO\nthe\tO\nOakland\tB-ORG\nAthletics\tI-ORG\n.\tO\n\nBoston\tB-ORG\nhas\tO\nwon\tO\n15\tO\nof\tO\nits\tO\nlast\tO\n19\tO\ngames\tT-0\n.\tO\n\nBoston\tB-ORG\n's\tO\nRoger\tT-0\nClemens\tT-0\n(\tO\n7-11\tO\n)\tO\nwas\tO\none\tO\nout\tO\naway\tO\nfrom\tO\nhis\tO\nsecond\tO\nstraight\tT-2\nshutout\tT-2\nwhen\tO\npinch-hitter\tO\nMatt\tO\nStairs\tO\ntripled\tO\nover\tO\nthe\tO\nhead\tO\nof\tO\ncentre\tO\nfielder\tO\nLee\tO\nTinsley\tO\non\tO\nan\tO\n0-2\tO\npitch\tO\nand\tO\npinch-hitter\tO\nTerry\tO\nSteinbach\tO\ndunked\tT-1\na\tO\nbroken-bat\tO\nsingle\tO\ninto\tO\nright\tO\nto\tO\nlift\tO\nOakland\tO\ninto\tO\na\tO\n1-1\tO\ntie\tO\n.\tO\n\nBoston\tT-2\n's\tO\nRoger\tB-PER\nClemens\tI-PER\n(\tT-3\n7-11\tT-3\n)\tT-3\nwas\tT-0\none\tT-0\nout\tO\naway\tO\nfrom\tO\nhis\tO\nsecond\tO\nstraight\tO\nshutout\tO\nwhen\tO\npinch-hitter\tO\nMatt\tT-1\nStairs\tT-1\ntripled\tO\nover\tO\nthe\tO\nhead\tO\nof\tO\ncentre\tO\nfielder\tO\nLee\tO\nTinsley\tO\non\tO\nan\tO\n0-2\tO\npitch\tO\nand\tO\npinch-hitter\tO\nTerry\tO\nSteinbach\tO\ndunked\tO\na\tO\nbroken-bat\tO\nsingle\tO\ninto\tO\nright\tO\nto\tO\nlift\tO\nOakland\tO\ninto\tO\na\tO\n1-1\tO\ntie\tO\n.\tO\n\nBoston\tT-1\n's\tO\nRoger\tO\nClemens\tO\n(\tO\n7-11\tO\n)\tO\nwas\tO\none\tO\nout\tO\naway\tO\nfrom\tO\nhis\tO\nsecond\tO\nstraight\tO\nshutout\tO\nwhen\tO\npinch-hitter\tT-0\nMatt\tB-PER\nStairs\tI-PER\ntripled\tO\nover\tO\nthe\tO\nhead\tO\nof\tO\ncentre\tO\nfielder\tO\nLee\tO\nTinsley\tO\non\tO\nan\tO\n0-2\tO\npitch\tO\nand\tO\npinch-hitter\tO\nTerry\tO\nSteinbach\tO\ndunked\tO\na\tO\nbroken-bat\tO\nsingle\tO\ninto\tO\nright\tO\nto\tO\nlift\tO\nOakland\tO\ninto\tO\na\tO\n1-1\tO\ntie\tO\n.\tO\n\nBoston\tO\n's\tO\nRoger\tO\nClemens\tO\n(\tO\n7-11\tO\n)\tO\nwas\tO\none\tO\nout\tO\naway\tO\nfrom\tO\nhis\tO\nsecond\tO\nstraight\tT-2\nshutout\tT-0\nwhen\tO\npinch-hitter\tO\nMatt\tT-3\nStairs\tT-3\ntripled\tO\nover\tO\nthe\tO\nhead\tO\nof\tO\ncentre\tO\nfielder\tT-1\nLee\tB-PER\nTinsley\tI-PER\non\tO\nan\tO\n0-2\tO\npitch\tO\nand\tO\npinch-hitter\tO\nTerry\tO\nSteinbach\tO\ndunked\tO\na\tO\nbroken-bat\tO\nsingle\tO\ninto\tO\nright\tO\nto\tO\nlift\tO\nOakland\tO\ninto\tO\na\tO\n1-1\tO\ntie\tO\n.\tO\n\nBoston\tT-1\n's\tT-1\nRoger\tT-1\nClemens\tT-1\n(\tO\n7-11\tO\n)\tO\nwas\tO\none\tO\nout\tO\naway\tO\nfrom\tO\nhis\tO\nsecond\tO\nstraight\tO\nshutout\tO\nwhen\tO\npinch-hitter\tO\nMatt\tO\nStairs\tO\ntripled\tT-2\nover\tO\nthe\tO\nhead\tO\nof\tO\ncentre\tO\nfielder\tO\nLee\tO\nTinsley\tO\non\tO\nan\tO\n0-2\tO\npitch\tO\nand\tO\npinch-hitter\tT-0\nTerry\tB-PER\nSteinbach\tI-PER\ndunked\tO\na\tO\nbroken-bat\tO\nsingle\tO\ninto\tO\nright\tO\nto\tO\nlift\tO\nOakland\tO\ninto\tO\na\tO\n1-1\tO\ntie\tO\n.\tO\n\nBoston\tO\n's\tO\nRoger\tO\nClemens\tO\n(\tO\n7-11\tO\n)\tO\nwas\tO\none\tO\nout\tO\naway\tO\nfrom\tO\nhis\tO\nsecond\tO\nstraight\tO\nshutout\tO\nwhen\tO\npinch-hitter\tO\nMatt\tO\nStairs\tO\ntripled\tO\nover\tO\nthe\tO\nhead\tO\nof\tO\ncentre\tO\nfielder\tO\nLee\tO\nTinsley\tO\non\tO\nan\tO\n0-2\tO\npitch\tO\nand\tO\npinch-hitter\tO\nTerry\tO\nSteinbach\tO\ndunked\tO\na\tO\nbroken-bat\tO\nsingle\tO\ninto\tO\nright\tT-0\nto\tO\nlift\tT-1\nOakland\tB-ORG\ninto\tT-2\na\tO\n1-1\tO\ntie\tO\n.\tO\n\nThe\tT-3\nrun\tT-3\nbroke\tT-3\nClemens\tB-PER\n'\tO\n28-inning\tT-0\nshutout\tT-1\nstreak\tT-2\n,\tO\nlongest\tT-4\nin\tT-4\nthe\tT-4\nmajors\tT-4\nthis\tT-4\nseason\tT-4\n.\tO\n\nReliever\tT-1\nMark\tB-PER\nAcre\tI-PER\n(\tO\n0-1\tO\n)\tO\ntook\tO\nthe\tO\nloss\tT-0\n.\tO\n\nIn\tT-0\nNew\tB-LOC\nYork\tI-LOC\n,\tO\nGarret\tO\nAnderson\tO\nand\tO\nGary\tO\nDiSarcina\tO\ndrove\tO\nin\tO\ntwo\tO\nruns\tO\napiece\tO\nin\tO\na\tO\nfive-run\tO\nfirst\tO\ninning\tO\nand\tO\nJim\tO\nEdmonds\tO\nhighlighted\tO\na\tO\nsix-run\tO\nsixth\tO\nwith\tO\na\tO\nbases-loaded\tO\ndouble\tO\nas\tO\nthe\tO\nCalifornia\tT-1\nAngels\tO\ncoasted\tO\nto\tO\na\tO\n12-3\tO\nvictory\tO\nover\tO\nthe\tO\nYankees\tO\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\ntheir\tO\nthree-game\tO\nseries\tO\n.\tO\n\nIn\tO\nNew\tT-1\nYork\tT-1\n,\tO\nGarret\tB-PER\nAnderson\tI-PER\nand\tO\nGary\tO\nDiSarcina\tO\ndrove\tT-0\nin\tO\ntwo\tO\nruns\tT-2\napiece\tO\nin\tO\na\tO\nfive-run\tO\nfirst\tO\ninning\tO\nand\tO\nJim\tO\nEdmonds\tO\nhighlighted\tO\na\tO\nsix-run\tO\nsixth\tO\nwith\tO\na\tO\nbases-loaded\tO\ndouble\tO\nas\tO\nthe\tO\nCalifornia\tO\nAngels\tO\ncoasted\tO\nto\tO\na\tO\n12-3\tO\nvictory\tO\nover\tO\nthe\tO\nYankees\tO\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\ntheir\tO\nthree-game\tO\nseries\tO\n.\tO\n\nIn\tO\nNew\tO\nYork\tO\n,\tO\nGarret\tT-0\nAnderson\tT-0\nand\tO\nGary\tB-PER\nDiSarcina\tI-PER\ndrove\tO\nin\tO\ntwo\tO\nruns\tO\napiece\tO\nin\tO\na\tO\nfive-run\tO\nfirst\tO\ninning\tO\nand\tO\nJim\tO\nEdmonds\tO\nhighlighted\tO\na\tO\nsix-run\tO\nsixth\tO\nwith\tO\na\tO\nbases-loaded\tO\ndouble\tO\nas\tO\nthe\tO\nCalifornia\tO\nAngels\tO\ncoasted\tO\nto\tO\na\tO\n12-3\tO\nvictory\tO\nover\tO\nthe\tO\nYankees\tO\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\ntheir\tO\nthree-game\tO\nseries\tO\n.\tO\n\nIn\tO\nNew\tO\nYork\tO\n,\tO\nGarret\tO\nAnderson\tO\nand\tO\nGary\tT-3\nDiSarcina\tT-3\ndrove\tO\nin\tO\ntwo\tO\nruns\tO\napiece\tO\nin\tO\na\tO\nfive-run\tO\nfirst\tO\ninning\tO\nand\tO\nJim\tB-PER\nEdmonds\tI-PER\nhighlighted\tT-1\na\tT-1\nsix-run\tT-1\nsixth\tT-1\nwith\tO\na\tO\nbases-loaded\tO\ndouble\tO\nas\tO\nthe\tO\nCalifornia\tT-2\nAngels\tT-4\ncoasted\tT-4\nto\tO\na\tO\n12-3\tO\nvictory\tO\nover\tO\nthe\tO\nYankees\tO\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\ntheir\tO\nthree-game\tO\nseries\tT-0\n.\tO\n\nIn\tO\nNew\tT-0\nYork\tT-0\n,\tO\nGarret\tT-1\nAnderson\tT-1\nand\tO\nGary\tT-2\nDiSarcina\tT-5\ndrove\tO\nin\tO\ntwo\tO\nruns\tO\napiece\tO\nin\tO\na\tO\nfive-run\tO\nfirst\tO\ninning\tO\nand\tO\nJim\tO\nEdmonds\tO\nhighlighted\tO\na\tO\nsix-run\tO\nsixth\tO\nwith\tO\na\tO\nbases-loaded\tO\ndouble\tO\nas\tO\nthe\tT-3\nCalifornia\tB-ORG\nAngels\tI-ORG\ncoasted\tT-4\nto\tO\na\tO\n12-3\tO\nvictory\tO\nover\tO\nthe\tO\nYankees\tO\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\ntheir\tO\nthree-game\tO\nseries\tO\n.\tO\n\nIn\tO\nNew\tO\nYork\tO\n,\tO\nGarret\tT-0\nAnderson\tT-0\nand\tO\nGary\tT-1\nDiSarcina\tT-1\ndrove\tO\nin\tO\ntwo\tO\nruns\tO\napiece\tO\nin\tO\na\tO\nfive-run\tO\nfirst\tO\ninning\tO\nand\tO\nJim\tT-2\nEdmonds\tT-2\nhighlighted\tT-5\na\tO\nsix-run\tO\nsixth\tO\nwith\tO\na\tO\nbases-loaded\tO\ndouble\tO\nas\tO\nthe\tO\nCalifornia\tT-3\nAngels\tT-3\ncoasted\tO\nto\tO\na\tO\n12-3\tO\nvictory\tO\nover\tT-4\nthe\tT-4\nYankees\tB-ORG\nin\tO\nthe\tO\nrubber\tO\ngame\tO\nof\tO\ntheir\tO\nthree-game\tO\nseries\tO\n.\tO\n\nThe\tO\nAngels\tB-ORG\nbattered\tT-1\nKenny\tT-0\nRogers\tT-0\n(\tT-0\n10-7\tO\n)\tO\nfor\tO\nfive\tT-2\nruns\tO\nin\tO\nthe\tO\nfirst\tO\n.\tO\n\nThe\tO\nAngels\tO\nbattered\tT-0\nKenny\tB-PER\nRogers\tI-PER\n(\tO\n10-7\tO\n)\tO\nfor\tO\nfive\tO\nruns\tO\nin\tO\nthe\tO\nfirst\tO\n.\tO\n\nThe\tO\nYankees\tB-ORG\nhave\tO\nallowed\tT-2\nat\tO\nleast\tO\ntwo\tO\nruns\tO\nin\tO\nthe\tO\nfirst\tO\ninning\tO\nin\tO\nsix\tO\nstraight\tO\ngames\tO\n,\tO\ngetting\tO\noutscored\tT-0\n21-1\tO\nin\tO\nthe\tO\nfirst\tO\ninning\tO\nin\tO\nthat\tO\nspan\tT-1\n.\tO\n\nChuck\tB-PER\nFinley\tI-PER\n(\tO\n12-12\tO\n)\tO\nsnapped\tT-0\na\tO\nfour-game\tO\nlosing\tO\nstreak\tO\n.\tO\n\nIn\tT-2\nKansas\tB-LOC\nCity\tI-LOC\n,\tO\nTravis\tO\nFryman\tO\ndoubled\tO\nin\tO\nthe\tO\ngo-ahead\tO\nrun\tO\nin\tO\nthe\tO\nfifth\tO\nand\tO\nMelvin\tO\nNieves\tO\nand\tO\nDamion\tO\nEasley\tO\nbelted\tO\ntwo-run\tO\nhomers\tO\nas\tO\nthe\tO\nDetroit\tO\nTigers\tO\nclaimed\tT-0\na\tO\n10-3\tO\nwin\tO\nover\tO\nthe\tO\nRoyals\tO\n,\tO\nhanding\tO\nthem\tO\ntheir\tO\nfifth\tO\nstraight\tO\nloss\tT-1\n.\tO\n\nIn\tO\nKansas\tT-0\nCity\tT-0\n,\tO\nTravis\tB-PER\nFryman\tI-PER\ndoubled\tT-3\nin\tO\nthe\tO\ngo-ahead\tO\nrun\tO\nin\tO\nthe\tO\nfifth\tO\nand\tO\nMelvin\tO\nNieves\tO\nand\tO\nDamion\tO\nEasley\tO\nbelted\tT-1\ntwo-run\tO\nhomers\tO\nas\tO\nthe\tO\nDetroit\tO\nTigers\tO\nclaimed\tO\na\tO\n10-3\tO\nwin\tT-2\nover\tO\nthe\tO\nRoyals\tO\n,\tO\nhanding\tO\nthem\tO\ntheir\tO\nfifth\tO\nstraight\tO\nloss\tO\n.\tO\n\nIn\tO\nKansas\tO\nCity\tO\n,\tO\nTravis\tO\nFryman\tO\ndoubled\tT-0\nin\tO\nthe\tO\ngo-ahead\tO\nrun\tO\nin\tO\nthe\tO\nfifth\tO\nand\tO\nMelvin\tB-PER\nNieves\tI-PER\nand\tO\nDamion\tO\nEasley\tO\nbelted\tO\ntwo-run\tO\nhomers\tO\nas\tO\nthe\tO\nDetroit\tO\nTigers\tO\nclaimed\tT-1\na\tO\n10-3\tO\nwin\tT-2\nover\tO\nthe\tO\nRoyals\tT-4\n,\tO\nhanding\tT-5\nthem\tO\ntheir\tO\nfifth\tO\nstraight\tO\nloss\tT-3\n.\tO\n\nIn\tO\nKansas\tT-1\nCity\tT-1\n,\tO\nTravis\tT-2\nFryman\tT-2\ndoubled\tO\nin\tO\nthe\tO\ngo-ahead\tO\nrun\tO\nin\tO\nthe\tO\nfifth\tO\nand\tO\nMelvin\tT-3\nNieves\tT-3\nand\tO\nDamion\tB-PER\nEasley\tI-PER\nbelted\tT-0\ntwo-run\tO\nhomers\tO\nas\tO\nthe\tO\nDetroit\tO\nTigers\tO\nclaimed\tO\na\tO\n10-3\tO\nwin\tO\nover\tO\nthe\tO\nRoyals\tO\n,\tO\nhanding\tO\nthem\tO\ntheir\tO\nfifth\tO\nstraight\tO\nloss\tO\n.\tO\n\nIn\tO\nKansas\tO\nCity\tO\n,\tO\nTravis\tO\nFryman\tO\ndoubled\tO\nin\tO\nthe\tO\ngo-ahead\tO\nrun\tO\nin\tO\nthe\tO\nfifth\tO\nand\tO\nMelvin\tO\nNieves\tO\nand\tO\nDamion\tO\nEasley\tO\nbelted\tO\ntwo-run\tO\nhomers\tO\nas\tO\nthe\tO\nDetroit\tB-ORG\nTigers\tI-ORG\nclaimed\tT-0\na\tO\n10-3\tO\nwin\tO\nover\tO\nthe\tO\nRoyals\tT-1\n,\tO\nhanding\tO\nthem\tO\ntheir\tO\nfifth\tO\nstraight\tO\nloss\tO\n.\tO\n\nIn\tO\nKansas\tO\nCity\tO\n,\tO\nTravis\tO\nFryman\tO\ndoubled\tO\nin\tO\nthe\tO\ngo-ahead\tO\nrun\tO\nin\tO\nthe\tO\nfifth\tO\nand\tO\nMelvin\tO\nNieves\tO\nand\tO\nDamion\tO\nEasley\tO\nbelted\tO\ntwo-run\tO\nhomers\tO\nas\tO\nthe\tO\nDetroit\tO\nTigers\tO\nclaimed\tO\na\tO\n10-3\tO\nwin\tO\nover\tO\nthe\tO\nRoyals\tB-ORG\n,\tO\nhanding\tT-0\nthem\tO\ntheir\tO\nfifth\tO\nstraight\tO\nloss\tO\n.\tO\n\nThe\tO\nTigers\tB-ORG\nwon\tT-2\ntheir\tO\nthird\tO\nstraight\tO\nand\tO\nhalted\tO\na\tO\nseven-game\tO\nroad\tO\nlosing\tT-0\nstreak\tO\nbehind\tO\nJustin\tT-1\nThompson\tT-1\n(\tO\n1-2\tO\n)\tO\n,\tO\nwho\tO\nearned\tO\nhis\tO\nfirst\tO\nmajor-league\tO\nwin\tO\n.\tO\n\nThe\tO\nTigers\tT-1\nwon\tO\ntheir\tO\nthird\tO\nstraight\tO\nand\tO\nhalted\tO\na\tO\nseven-game\tO\nroad\tO\nlosing\tO\nstreak\tO\nbehind\tT-2\nJustin\tB-PER\nThompson\tI-PER\n(\tO\n1-2\tO\n)\tO\n,\tO\nwho\tT-0\nearned\tT-0\nhis\tT-0\nfirst\tT-0\nmajor-league\tT-0\nwin\tT-0\n.\tO\n\nTim\tB-PER\nBelcher\tI-PER\n(\tO\n12-8\tO\n)\tO\nwas\tO\ntagged\tT-0\nfor\tO\nsix\tO\nruns\tO\nand\tO\nnine\tO\nhits\tO\nin\tO\neight\tO\ninnings\tO\n.\tO\n\nAt\tT-2\nMinnesota\tB-LOC\n,\tO\nKen\tO\nHill\tO\nallowed\tT-1\ntwo\tT-1\nruns\tT-1\nen\tO\nroute\tO\nto\tO\nhis\tO\nsixth\tO\ncomplete\tO\ngame\tO\nof\tO\nthe\tO\nseason\tO\nand\tO\nRusty\tO\nGreer\tO\nadded\tO\nthree\tO\nhits\tO\n,\tO\nincluding\tO\na\tO\nhomer\tO\n,\tO\nand\tO\ntwo\tO\nRBI\tO\nas\tO\nthe\tO\nred-hot\tO\nTexas\tT-0\nRangers\tT-0\nrouted\tO\nthe\tT-3\nTwins\tT-3\n11-2\tO\n.\tO\n\nAt\tO\nMinnesota\tO\n,\tO\nKen\tB-PER\nHill\tI-PER\nallowed\tO\ntwo\tO\nruns\tO\nen\tO\nroute\tO\nto\tO\nhis\tO\nsixth\tO\ncomplete\tO\ngame\tT-0\nof\tO\nthe\tO\nseason\tT-1\nand\tO\nRusty\tO\nGreer\tO\nadded\tT-2\nthree\tO\nhits\tO\n,\tO\nincluding\tO\na\tO\nhomer\tO\n,\tO\nand\tO\ntwo\tO\nRBI\tO\nas\tO\nthe\tO\nred-hot\tO\nTexas\tO\nRangers\tO\nrouted\tO\nthe\tO\nTwins\tO\n11-2\tO\n.\tO\n\nAt\tO\nMinnesota\tT-4\n,\tO\nKen\tT-5\nHill\tT-5\nallowed\tO\ntwo\tO\nruns\tO\nen\tO\nroute\tO\nto\tO\nhis\tO\nsixth\tO\ncomplete\tO\ngame\tT-0\nof\tO\nthe\tO\nseason\tO\nand\tO\nRusty\tB-PER\nGreer\tI-PER\nadded\tO\nthree\tT-1\nhits\tT-1\n,\tO\nincluding\tO\na\tO\nhomer\tT-3\n,\tO\nand\tO\ntwo\tT-2\nRBI\tO\nas\tO\nthe\tO\nred-hot\tO\nTexas\tT-6\nRangers\tT-6\nrouted\tO\nthe\tO\nTwins\tO\n11-2\tO\n.\tT-2\n\nAt\tO\nMinnesota\tT-1\n,\tO\nKen\tT-2\nHill\tT-2\nallowed\tO\ntwo\tO\nruns\tO\nen\tO\nroute\tO\nto\tO\nhis\tO\nsixth\tO\ncomplete\tO\ngame\tO\nof\tO\nthe\tO\nseason\tO\nand\tO\nRusty\tO\nGreer\tO\nadded\tO\nthree\tO\nhits\tO\n,\tO\nincluding\tO\na\tO\nhomer\tO\n,\tO\nand\tT-0\ntwo\tT-0\nRBI\tB-MISC\nas\tO\nthe\tO\nred-hot\tO\nTexas\tO\nRangers\tO\nrouted\tO\nthe\tO\nTwins\tO\n11-2\tO\n.\tO\n\nAt\tO\nMinnesota\tO\n,\tO\nKen\tO\nHill\tO\nallowed\tO\ntwo\tO\nruns\tO\nen\tO\nroute\tO\nto\tO\nhis\tO\nsixth\tO\ncomplete\tO\ngame\tO\nof\tO\nthe\tO\nseason\tT-2\nand\tO\nRusty\tO\nGreer\tO\nadded\tT-0\nthree\tO\nhits\tO\n,\tO\nincluding\tO\na\tO\nhomer\tO\n,\tO\nand\tO\ntwo\tO\nRBI\tO\nas\tO\nthe\tO\nred-hot\tO\nTexas\tB-ORG\nRangers\tI-ORG\nrouted\tT-1\nthe\tO\nTwins\tO\n11-2\tO\n.\tO\n\nAt\tO\nMinnesota\tO\n,\tO\nKen\tO\nHill\tO\nallowed\tO\ntwo\tO\nruns\tO\nen\tO\nroute\tO\nto\tO\nhis\tO\nsixth\tO\ncomplete\tO\ngame\tO\nof\tO\nthe\tO\nseason\tO\nand\tO\nRusty\tO\nGreer\tO\nadded\tO\nthree\tO\nhits\tO\n,\tO\nincluding\tO\na\tO\nhomer\tO\n,\tO\nand\tO\ntwo\tO\nRBI\tO\nas\tO\nthe\tO\nred-hot\tO\nTexas\tO\nRangers\tO\nrouted\tT-0\nthe\tT-0\nTwins\tB-ORG\n11-2\tO\n.\tO\n\nThe\tO\nRangers\tB-ORG\n,\tO\nwho\tO\nwon\tT-0\nfor\tO\nthe\tO\n11th\tO\ntime\tO\nin\tO\ntheir\tO\nlast\tO\n13\tO\ngames\tO\n,\tO\nhave\tO\nscored\tT-1\n45\tO\nruns\tO\nin\tO\ntheir\tO\nlast\tO\nfive\tO\ncontests\tO\n.\tO\n\nHill\tB-PER\n(\tO\n14-7\tO\n)\tO\nallowed\tT-0\n10\tT-0\nhits\tT-0\n.\tO\n\nIn\tT-0\nChicago\tB-LOC\n,\tO\nErik\tO\nHanson\tO\noutdueled\tT-1\nAlex\tO\nFernandez\tO\n,\tO\nand\tO\nJacob\tO\nBrumfield\tO\ndrove\tO\nin\tO\nOtis\tO\nNixon\tO\nwith\tO\nthe\tO\ngame\tO\n's\tO\nonly\tO\nrun\tO\nin\tO\nthe\tO\nsixth\tO\ninning\tO\nas\tO\nthe\tO\nToronto\tO\nBlue\tO\nJays\tO\nblanked\tO\nthe\tO\nWhite\tO\nSox\tO\n1-0\tO\nin\tO\na\tO\ngame\tO\nshortened\tO\nto\tO\nsix\tO\ninnings\tO\ndue\tO\nto\tO\nrain\tO\n.\tO\n\nIn\tO\nChicago\tT-1\n,\tO\nErik\tB-PER\nHanson\tI-PER\noutdueled\tT-0\nAlex\tT-2\nFernandez\tT-2\n,\tO\nand\tO\nJacob\tT-3\nBrumfield\tT-3\ndrove\tO\nin\tO\nOtis\tO\nNixon\tT-4\nwith\tO\nthe\tO\ngame\tO\n's\tO\nonly\tO\nrun\tO\nin\tO\nthe\tO\nsixth\tO\ninning\tO\nas\tO\nthe\tO\nToronto\tT-6\nBlue\tT-6\nJays\tT-6\nblanked\tO\nthe\tO\nWhite\tO\nSox\tO\n1-0\tO\nin\tO\na\tO\ngame\tO\nshortened\tO\nto\tO\nsix\tO\ninnings\tT-5\ndue\tO\nto\tO\nrain\tO\n.\tO\n\nIn\tO\nChicago\tO\n,\tO\nErik\tT-1\nHanson\tT-1\noutdueled\tT-0\nAlex\tB-PER\nFernandez\tI-PER\n,\tO\nand\tO\nJacob\tO\nBrumfield\tO\ndrove\tO\nin\tO\nOtis\tT-2\nNixon\tT-3\nwith\tO\nthe\tO\ngame\tO\n's\tO\nonly\tO\nrun\tO\nin\tO\nthe\tO\nsixth\tO\ninning\tO\nas\tO\nthe\tO\nToronto\tO\nBlue\tO\nJays\tO\nblanked\tO\nthe\tO\nWhite\tO\nSox\tO\n1-0\tO\nin\tO\na\tO\ngame\tO\nshortened\tO\nto\tO\nsix\tO\ninnings\tO\ndue\tO\nto\tO\nrain\tO\n.\tO\n\nIn\tO\nChicago\tO\n,\tO\nErik\tO\nHanson\tO\noutdueled\tO\nAlex\tO\nFernandez\tO\n,\tO\nand\tO\nJacob\tB-PER\nBrumfield\tI-PER\ndrove\tT-0\nin\tO\nOtis\tO\nNixon\tO\nwith\tO\nthe\tO\ngame\tO\n's\tO\nonly\tO\nrun\tO\nin\tO\nthe\tO\nsixth\tO\ninning\tO\nas\tO\nthe\tO\nToronto\tO\nBlue\tO\nJays\tO\nblanked\tO\nthe\tO\nWhite\tO\nSox\tO\n1-0\tO\nin\tO\na\tO\ngame\tO\nshortened\tO\nto\tO\nsix\tO\ninnings\tO\ndue\tO\nto\tO\nrain\tO\n.\tO\n\nIn\tO\nChicago\tT-1\n,\tO\nErik\tT-4\nHanson\tT-4\noutdueled\tT-5\nAlex\tT-2\nFernandez\tT-2\n,\tO\nand\tO\nJacob\tT-3\nBrumfield\tT-3\ndrove\tO\nin\tT-0\nOtis\tB-PER\nNixon\tI-PER\nwith\tO\nthe\tO\ngame\tO\n's\tO\nonly\tO\nrun\tO\nin\tO\nthe\tO\nsixth\tO\ninning\tO\nas\tO\nthe\tO\nToronto\tO\nBlue\tO\nJays\tO\nblanked\tO\nthe\tO\nWhite\tO\nSox\tO\n1-0\tO\nin\tO\na\tO\ngame\tO\nshortened\tO\nto\tO\nsix\tO\ninnings\tO\ndue\tO\nto\tO\nrain\tO\n.\tO\n\nIn\tO\nChicago\tT-1\n,\tO\nErik\tT-2\nHanson\tT-2\noutdueled\tO\nAlex\tT-3\nFernandez\tT-3\n,\tO\nand\tO\nJacob\tO\nBrumfield\tO\ndrove\tO\nin\tO\nOtis\tO\nNixon\tO\nwith\tO\nthe\tO\ngame\tO\n's\tO\nonly\tO\nrun\tO\nin\tO\nthe\tO\nsixth\tO\ninning\tO\nas\tO\nthe\tO\nToronto\tB-ORG\nBlue\tI-ORG\nJays\tI-ORG\nblanked\tT-0\nthe\tO\nWhite\tO\nSox\tO\n1-0\tO\nin\tO\na\tO\ngame\tO\nshortened\tO\nto\tO\nsix\tO\ninnings\tO\ndue\tO\nto\tO\nrain\tO\n.\tO\n\nIn\tO\nChicago\tO\n,\tO\nErik\tT-0\nHanson\tT-0\noutdueled\tO\nAlex\tT-1\nFernandez\tT-1\n,\tO\nand\tO\nJacob\tT-2\nBrumfield\tT-2\ndrove\tO\nin\tO\nOtis\tO\nNixon\tO\nwith\tO\nthe\tO\ngame\tO\n's\tO\nonly\tO\nrun\tO\nin\tO\nthe\tO\nsixth\tO\ninning\tO\nas\tO\nthe\tO\nToronto\tO\nBlue\tO\nJays\tO\nblanked\tT-3\nthe\tO\nWhite\tB-ORG\nSox\tI-ORG\n1-0\tO\nin\tO\na\tO\ngame\tO\nshortened\tO\nto\tO\nsix\tO\ninnings\tO\ndue\tO\nto\tO\nrain\tO\n.\tO\n\nToronto\tB-ORG\nwon\tO\nits\tO\nfifth\tO\nstraight\tO\nand\tO\nhanded\tT-0\nthe\tO\nWhite\tO\nSox\tO\ntheir\tO\nseventh\tO\nloss\tO\nin\tO\nnine\tO\ngames\tO\n.\tO\n\nToronto\tT-0\nwon\tT-0\nits\tT-0\nfifth\tT-0\nstraight\tT-0\nand\tT-0\nhanded\tT-0\nthe\tT-0\nWhite\tB-ORG\nSox\tI-ORG\ntheir\tT-1\nseventh\tT-1\nloss\tT-1\nin\tT-1\nnine\tT-1\ngames\tT-1\n.\tT-2\n\nHanson\tB-PER\n(\tO\n11-15\tO\n)\tO\nallowed\tO\nthree\tO\nhits\tO\n,\tO\nwalked\tT-0\nthree\tO\nand\tO\nstruck\tO\nout\tO\nfour\tO\nto\tO\nsnap\tO\na\tO\npersonal\tO\nthree-game\tO\nlosing\tO\nstreak\tO\n.\tO\n\nFernandez\tB-PER\n(\tO\n12-8\tT-1\n)\tO\nscattered\tO\nsix\tO\nhits\tT-0\n.\tO\n\nSOCCER\tO\n-\tO\nSPORTING\tB-ORG\nSTART\tT-0\nNEW\tO\nSEASON\tT-2\nWITH\tO\nA\tO\nWIN\tT-1\n.\tO\n\nSporting\tB-ORG\n's\tO\nLuis\tO\nMiguel\tO\nPredrosa\tO\nscored\tO\nthe\tO\nfirst\tO\ngoal\tO\nof\tO\nthe\tO\nnew\tO\nleague\tO\nseason\tO\nas\tO\nthe\tO\nLisbon\tO\nside\tO\ncruised\tO\nto\tO\na\tO\n3-1\tO\naway\tO\nwin\tO\nover\tO\nSC\tT-0\nEspinho\tT-0\non\tO\nFriday\tO\n.\tO\n\nSporting\tT-0\n's\tT-0\nLuis\tB-PER\nMiguel\tI-PER\nPredrosa\tI-PER\nscored\tO\nthe\tO\nfirst\tO\ngoal\tO\nof\tO\nthe\tO\nnew\tO\nleague\tO\nseason\tO\nas\tO\nthe\tO\nLisbon\tO\nside\tO\ncruised\tO\nto\tO\na\tO\n3-1\tO\naway\tO\nwin\tO\nover\tO\nSC\tO\nEspinho\tO\non\tO\nFriday\tO\n.\tO\n\nSporting\tO\n's\tO\nLuis\tO\nMiguel\tO\nPredrosa\tO\nscored\tO\nthe\tO\nfirst\tO\ngoal\tO\nof\tO\nthe\tO\nnew\tO\nleague\tO\nseason\tO\nas\tO\nthe\tO\nLisbon\tB-LOC\nside\tT-0\ncruised\tO\nto\tO\na\tO\n3-1\tO\naway\tO\nwin\tO\nover\tO\nSC\tO\nEspinho\tO\non\tO\nFriday\tO\n.\tO\n\nSporting\tO\n's\tO\nLuis\tO\nMiguel\tT-2\nPredrosa\tT-2\nscored\tO\nthe\tO\nfirst\tO\ngoal\tO\nof\tO\nthe\tO\nnew\tO\nleague\tO\nseason\tO\nas\tO\nthe\tO\nLisbon\tO\nside\tO\ncruised\tO\nto\tO\na\tO\n3-1\tO\naway\tO\nwin\tT-0\nover\tT-0\nSC\tB-ORG\nEspinho\tI-ORG\non\tO\nFriday\tO\n.\tO\n\nPredrosa\tB-PER\ndrilled\tT-1\na\tO\nright-foot\tT-0\nshot\tO\ninto\tO\nthe\tO\nback\tO\nof\tO\nthe\tO\nnet\tO\nafter\tO\n24\tO\nminutes\tO\nto\tO\nset\tO\nSporting\tT-2\non\tO\nthe\tO\nway\tO\nto\tO\nvictory\tO\n.\tO\n\nPredrosa\tT-1\ndrilled\tO\na\tO\nright-foot\tT-2\nshot\tT-2\ninto\tO\nthe\tO\nback\tO\nof\tO\nthe\tO\nnet\tO\nafter\tO\n24\tO\nminutes\tO\nto\tT-0\nset\tT-0\nSporting\tB-ORG\non\tO\nthe\tO\nway\tO\nto\tO\nvictory\tT-3\n.\tO\n\nAlthough\tT-2\nEspinho\tB-ORG\n's\tO\nNail\tO\nBesirovic\tT-0\nput\tO\nthe\tO\nhome\tT-3\nside\tT-1\nback\tO\non\tO\nterms\tO\nin\tO\nthe\tO\n35th\tO\nminute\tO\n,\tO\nSporting\tO\nquickly\tO\nrestored\tO\ntheir\tO\nlead\tO\n.\tO\n\nAlthough\tO\nEspinho\tO\n's\tO\nNail\tB-PER\nBesirovic\tI-PER\nput\tO\nthe\tO\nhome\tO\nside\tO\nback\tO\non\tO\nterms\tO\nin\tO\nthe\tO\n35th\tT-0\nminute\tO\n,\tO\nSporting\tO\nquickly\tO\nrestored\tO\ntheir\tO\nlead\tO\n.\tO\n\nAlthough\tO\nEspinho\tT-2\n's\tO\nNail\tT-3\nBesirovic\tT-3\nput\tO\nthe\tO\nhome\tO\nside\tO\nback\tO\non\tO\nterms\tO\nin\tO\nthe\tO\n35th\tO\nminute\tO\n,\tO\nSporting\tB-ORG\nquickly\tT-0\nrestored\tT-1\ntheir\tT-1\nlead\tT-1\n.\tO\n\nJose\tB-PER\nLuis\tI-PER\nVidigal\tI-PER\nscored\tT-1\nin\tO\nthe\tO\n38th\tO\nminute\tO\nand\tO\nMustapha\tT-0\nHadji\tT-0\nadded\tO\nthe\tO\nthird\tO\nin\tO\nthe\tO\n57th\tO\n.\tO\n\nJose\tT-1\nLuis\tT-1\nVidigal\tT-1\nscored\tT-0\nin\tO\nthe\tO\n38th\tO\nminute\tO\nand\tO\nMustapha\tB-PER\nHadji\tI-PER\nadded\tT-2\nthe\tT-2\nthird\tT-2\nin\tT-2\nthe\tT-2\n57th\tT-2\n.\tO\n\nThe\tO\ngame\tT-3\nwas\tO\nbrought\tO\nforward\tO\nfrom\tO\nSunday\tO\nwhen\tO\nreigning\tO\nchampions\tT-0\nPorto\tB-ORG\nand\tT-1\nLisbon\tO\nrivals\tO\nBenfica\tO\nplay\tT-2\ntheir\tO\nfirst\tO\ngames\tO\nof\tO\nthe\tO\nseason\tO\n.\tO\n\nThe\tO\ngame\tO\nwas\tO\nbrought\tT-0\nforward\tO\nfrom\tO\nSunday\tO\nwhen\tO\nreigning\tT-1\nchampions\tT-1\nPorto\tO\nand\tT-2\nLisbon\tB-ORG\nrivals\tT-3\nBenfica\tO\nplay\tO\ntheir\tO\nfirst\tO\ngames\tO\nof\tO\nthe\tO\nseason\tO\n.\tO\n\nThe\tO\ngame\tO\nwas\tO\nbrought\tO\nforward\tO\nfrom\tO\nSunday\tO\nwhen\tO\nreigning\tO\nchampions\tT-1\nPorto\tO\nand\tO\nLisbon\tO\nrivals\tO\nBenfica\tB-ORG\nplay\tT-0\ntheir\tO\nfirst\tO\ngames\tO\nof\tO\nthe\tO\nseason\tO\n.\tO\n\nSOCCER\tT-1\n-\tO\nPORTUGUESE\tB-MISC\nFIRST\tO\nDIVISION\tO\nRESULT\tT-0\n.\tO\n\nResult\tT-0\nof\tO\na\tO\nPortuguese\tB-MISC\nfirst\tO\n\nEspinho\tT-0\n1\tO\nSporting\tB-ORG\n3\tO\n\nSOCCER\tT-2\n-\tO\nST\tB-ORG\nPAULI\tI-ORG\nTAKE\tT-0\nPOINT\tO\nWITH\tO\nLATE\tO\nFIGHTBACK\tT-1\n.\tO\n\nHamburg\tB-LOC\nside\tO\nSt\tT-2\nPauli\tT-2\n,\tO\ntipped\tO\nas\tO\nprime\tO\ncandidates\tO\nfor\tO\nrelegation\tT-0\n,\tO\nproduced\tO\na\tO\nstunning\tO\nsecond-half\tO\nfightback\tO\nto\tO\ndraw\tO\n4-4\tO\nin\tO\ntheir\tO\nBundesliga\tT-1\nclash\tO\nwith\tO\nSchalke\tO\non\tO\nFriday\tO\n.\tO\n\nHamburg\tT-1\nside\tT-0\nSt\tB-ORG\nPauli\tI-ORG\n,\tO\ntipped\tO\nas\tO\nprime\tT-2\ncandidates\tT-2\nfor\tO\nrelegation\tO\n,\tO\nproduced\tO\na\tO\nstunning\tO\nsecond-half\tO\nfightback\tO\nto\tO\ndraw\tO\n4-4\tO\nin\tO\ntheir\tO\nBundesliga\tO\nclash\tO\nwith\tO\nSchalke\tO\non\tO\nFriday\tO\n.\tO\n\nHamburg\tO\nside\tO\nSt\tO\nPauli\tO\n,\tO\ntipped\tO\nas\tO\nprime\tO\ncandidates\tO\nfor\tO\nrelegation\tO\n,\tO\nproduced\tT-3\na\tO\nstunning\tO\nsecond-half\tT-1\nfightback\tT-1\nto\tO\ndraw\tO\n4-4\tO\nin\tO\ntheir\tT-0\nBundesliga\tB-MISC\nclash\tT-2\nwith\tT-2\nSchalke\tT-2\non\tO\nFriday\tO\n.\tO\n\nHamburg\tO\nside\tT-0\nSt\tO\nPauli\tO\n,\tO\ntipped\tO\nas\tO\nprime\tO\ncandidates\tO\nfor\tO\nrelegation\tT-1\n,\tO\nproduced\tT-3\na\tO\nstunning\tO\nsecond-half\tO\nfightback\tO\nto\tO\ndraw\tO\n4-4\tO\nin\tO\ntheir\tO\nBundesliga\tO\nclash\tO\nwith\tT-2\nSchalke\tB-ORG\non\tO\nFriday\tO\n.\tO\n\nSchalke\tB-ORG\n,\tO\nwho\tO\nfinished\tT-0\nthird\tO\nlast\tO\nseason\tT-3\n,\tO\nraced\tT-1\nto\tO\na\tO\n3-1\tO\nlead\tO\nat\tO\nhalftime\tT-2\n.\tO\n\nSt\tB-ORG\nPauli\tI-ORG\npulled\tT-1\na\tO\ngoal\tT-2\nback\tO\nthrough\tO\nAndre\tO\nTrulsen\tO\nbut\tO\nSchalke\tO\nstriker\tO\nMartin\tO\nMax\tO\nrestored\tT-0\nhis\tO\nteam\tO\n's\tO\ntwo-goal\tO\ncushion\tO\nshortly\tO\nafterwards\tO\n.\tO\n\nSt\tO\nPauli\tO\npulled\tO\na\tO\ngoal\tO\nback\tO\nthrough\tO\nAndre\tB-PER\nTrulsen\tI-PER\nbut\tO\nSchalke\tO\nstriker\tT-1\nMartin\tO\nMax\tO\nrestored\tT-3\nhis\tT-0\nteam\tO\n's\tO\ntwo-goal\tO\ncushion\tO\nshortly\tO\nafterwards\tT-2\n.\tO\n\nSt\tO\nPauli\tO\npulled\tT-1\na\tO\ngoal\tO\nback\tO\nthrough\tT-2\nAndre\tT-4\nTrulsen\tT-4\nbut\tO\nSchalke\tB-ORG\nstriker\tT-0\nMartin\tT-0\nMax\tT-0\nrestored\tT-3\nhis\tO\nteam\tO\n's\tO\ntwo-goal\tO\ncushion\tO\nshortly\tO\nafterwards\tO\n.\tO\n\nSt\tO\nPauli\tO\npulled\tT-2\na\tO\ngoal\tO\nback\tO\nthrough\tO\nAndre\tO\nTrulsen\tO\nbut\tO\nSchalke\tO\nstriker\tT-3\nMartin\tB-PER\nMax\tI-PER\nrestored\tT-1\nhis\tT-4\nteam\tO\n's\tO\ntwo-goal\tO\ncushion\tO\nshortly\tO\nafterwards\tO\n.\tO\n\nChristian\tB-PER\nSpringer\tI-PER\nput\tT-1\nSt\tO\nPauli\tO\nback\tO\nin\tO\ntouch\tO\nin\tO\nthe\tO\n64th\tO\nminute\tO\nand\tO\nthree\tO\nminutes\tO\nlater\tO\nthey\tO\nwere\tO\nlevel\tO\n,\tO\nthanks\tO\nto\tO\na\tO\npenalty\tT-0\nfrom\tO\nThomas\tO\nSabotzik\tO\n.\tO\n\nChristian\tO\nSpringer\tO\nput\tT-2\nSt\tB-ORG\nPauli\tI-ORG\nback\tO\nin\tO\ntouch\tT-0\nin\tO\nthe\tO\n64th\tO\nminute\tO\nand\tO\nthree\tO\nminutes\tO\nlater\tO\nthey\tO\nwere\tO\nlevel\tO\n,\tO\nthanks\tO\nto\tO\na\tO\npenalty\tT-1\nfrom\tO\nThomas\tO\nSabotzik\tO\n.\tO\n\nChristian\tT-3\nSpringer\tT-3\nput\tT-0\nSt\tT-4\nPauli\tT-4\nback\tO\nin\tO\ntouch\tT-1\nin\tO\nthe\tO\n64th\tO\nminute\tO\nand\tO\nthree\tO\nminutes\tO\nlater\tO\nthey\tO\nwere\tO\nlevel\tO\n,\tO\nthanks\tO\nto\tO\na\tO\npenalty\tO\nfrom\tO\nThomas\tB-PER\nSabotzik\tI-PER\n.\tO\n\nIn\tO\nthe\tO\nnight\tO\n's\tO\nonly\tO\nother\tO\nmatch\tO\n,\tO\nHamburg\tB-ORG\nbeat\tT-0\nHansa\tO\nRostock\tO\n1-0\tO\n,\tO\nKarsten\tT-1\nBaeron\tT-1\nscoring\tO\nthe\tO\nwinner\tO\nafter\tO\nsome\tO\ndazzling\tO\nbuild-up\tO\nfrom\tO\nin-form\tO\nmidfielder\tO\nHarald\tT-2\nSpoerl\tT-2\n.\tO\n\nIn\tO\nthe\tO\nnight\tO\n's\tO\nonly\tO\nother\tO\nmatch\tO\n,\tO\nHamburg\tT-1\nbeat\tT-3\nHansa\tB-ORG\nRostock\tI-ORG\n1-0\tO\n,\tO\nKarsten\tO\nBaeron\tO\nscoring\tO\nthe\tO\nwinner\tT-0\nafter\tO\nsome\tO\ndazzling\tO\nbuild-up\tO\nfrom\tO\nin-form\tO\nmidfielder\tO\nHarald\tT-2\nSpoerl\tT-2\n.\tO\n\nIn\tO\nthe\tO\nnight\tO\n's\tO\nonly\tO\nother\tO\nmatch\tO\n,\tO\nHamburg\tO\nbeat\tO\nHansa\tO\nRostock\tO\n1-0\tO\n,\tO\nKarsten\tB-PER\nBaeron\tI-PER\nscoring\tO\nthe\tO\nwinner\tT-0\nafter\tO\nsome\tO\ndazzling\tO\nbuild-up\tO\nfrom\tO\nin-form\tO\nmidfielder\tO\nHarald\tO\nSpoerl\tO\n.\tO\n\nIn\tO\nthe\tO\nnight\tO\n's\tO\nonly\tO\nother\tO\nmatch\tO\n,\tO\nHamburg\tT-0\nbeat\tO\nHansa\tO\nRostock\tO\n1-0\tO\n,\tO\nKarsten\tO\nBaeron\tO\nscoring\tO\nthe\tO\nwinner\tO\nafter\tO\nsome\tO\ndazzling\tO\nbuild-up\tO\nfrom\tO\nin-form\tO\nmidfielder\tO\nHarald\tB-PER\nSpoerl\tI-PER\n.\tO\n\nThe\tO\nwin\tT-0\nput\tT-2\nHamburg\tB-ORG\nin\tO\nsecond\tT-3\nplace\tO\nin\tO\nthe\tO\nGerman\tO\nfirst\tT-1\ndivision\tT-1\nafter\tO\nthree\tO\ngames\tO\n,\tO\nthough\tO\nthat\tO\nmay\tO\nchange\tO\nafter\tO\nthe\tO\nother\tO\nsides\tO\nplay\tO\non\tO\nSaturday\tO\n.\tO\n\nThe\tO\nwin\tO\nput\tO\nHamburg\tT-1\nin\tO\nsecond\tT-0\nplace\tO\nin\tO\nthe\tO\nGerman\tB-MISC\nfirst\tO\ndivision\tO\nafter\tO\nthree\tO\ngames\tO\n,\tO\nthough\tO\nthat\tO\nmay\tO\nchange\tO\nafter\tO\nthe\tO\nother\tO\nsides\tO\nplay\tO\non\tO\nSaturday\tO\n.\tO\n\nATHLETICS\tT-0\n-\tO\nSALAH\tB-PER\nHISSOU\tI-PER\nBREAKS\tO\n10,000\tO\nMETRES\tO\nWORLD\tO\nRECORD\tO\n.\tO\n\nMorocco\tB-LOC\n's\tO\nSalah\tO\nHissou\tO\nbroke\tT-0\nthe\tO\nmen\tO\n's\tO\n10,000\tO\nmetres\tO\nworld\tO\nrecord\tO\non\tO\nFriday\tO\nwhen\tO\nhe\tO\nclocked\tT-1\n26\tO\nminutes\tO\n38.08\tO\nseconds\tO\nat\tO\nthe\tO\nBrussels\tO\ngrand\tO\nprix\tO\non\tO\nFriday\tO\n.\tO\n\nMorocco\tO\n's\tO\nSalah\tB-PER\nHissou\tI-PER\nbroke\tO\nthe\tO\nmen\tO\n's\tO\n10,000\tO\nmetres\tO\nworld\tO\nrecord\tO\non\tO\nFriday\tO\nwhen\tO\nhe\tT-0\nclocked\tO\n26\tO\nminutes\tO\n38.08\tO\nseconds\tO\nat\tO\nthe\tO\nBrussels\tO\ngrand\tO\nprix\tO\non\tO\nFriday\tO\n.\tO\n\nMorocco\tO\n's\tO\nSalah\tO\nHissou\tO\nbroke\tT-1\nthe\tO\nmen\tO\n's\tO\n10,000\tO\nmetres\tO\nworld\tT-0\nrecord\tT-0\non\tO\nFriday\tO\nwhen\tO\nhe\tO\nclocked\tT-2\n26\tO\nminutes\tO\n38.08\tO\nseconds\tO\nat\tT-3\nthe\tO\nBrussels\tB-LOC\ngrand\tO\nprix\tO\non\tO\nFriday\tO\n.\tO\n\nThe\tO\nprevious\tO\nmark\tO\nof\tO\n26:43.53\tO\nwas\tO\nset\tO\nby\tT-0\nEthiopia\tB-LOC\n's\tO\nHaile\tT-2\nGebreselassie\tT-3\nin\tO\nthe\tO\nDutch\tT-1\ntown\tO\nof\tO\nHengelo\tT-4\nin\tO\nJune\tO\nlast\tO\nyear\tO\n.\tO\n\nThe\tT-0\nprevious\tT-0\nmark\tT-0\nof\tO\n26:43.53\tO\nwas\tT-1\nset\tT-3\nby\tT-3\nEthiopia\tO\n's\tO\nHaile\tB-PER\nGebreselassie\tI-PER\nin\tO\nthe\tO\nDutch\tO\ntown\tT-2\nof\tT-2\nHengelo\tT-2\nin\tO\nJune\tO\nlast\tO\nyear\tO\n.\tO\n\nThe\tO\nprevious\tO\nmark\tO\nof\tO\n26:43.53\tO\nwas\tO\nset\tT-0\nby\tO\nEthiopia\tO\n's\tO\nHaile\tO\nGebreselassie\tO\nin\tO\nthe\tO\nDutch\tB-MISC\ntown\tT-1\nof\tO\nHengelo\tO\nin\tO\nJune\tO\nlast\tO\nyear\tO\n.\tO\n\nThe\tO\nprevious\tO\nmark\tO\nof\tO\n26:43.53\tO\nwas\tO\nset\tO\nby\tO\nEthiopia\tO\n's\tO\nHaile\tO\nGebreselassie\tO\nin\tO\nthe\tO\nDutch\tO\ntown\tT-0\nof\tO\nHengelo\tB-LOC\nin\tO\nJune\tO\nlast\tO\nyear\tO\n.\tO\n\nSOCCER\tO\n-\tO\nGERMAN\tB-MISC\nFIRST\tT-0\nDIVISION\tT-0\nSUMMARIES\tT-0\n.\tO\n\nSummaries\tT-2\nof\tO\nBundesliga\tB-MISC\nmatches\tT-0\non\tO\nFriday\tT-1\n:\tO\n\nHansa\tB-ORG\nRostock\tI-ORG\n0\tO\nHamburg\tT-1\n1\tO\n(\tO\nBaeron\tT-0\n64th\tO\nmin\tO\n)\tO\n.\tO\n\nHansa\tO\nRostock\tO\n0\tO\nHamburg\tT-0\n1\tT-0\n(\tO\nBaeron\tB-PER\n64th\tT-1\nmin\tT-1\n)\tO\n.\tO\n\nSt\tB-ORG\nPauli\tI-ORG\n4\tT-1\n(\tO\nDriller\tO\n15th\tO\n,\tO\nTrulsen\tO\n54th\tO\n,\tO\nSpringer\tO\n64th\tO\n,\tO\nSobotzik\tO\n67th\tO\npenalty\tO\n)\tO\nSchalke\tT-0\n4\tO\n(\tO\nMax\tO\n11th\tO\n,\tO\nThon\tO\n34th\tO\n,\tO\nWilmots\tO\n38th\tO\n,\tO\nSpringer\tO\n64th\tO\n)\tO\n.\tO\n\nSt\tO\nPauli\tO\n4\tO\n(\tO\nDriller\tB-PER\n15th\tT-1\n,\tO\nTrulsen\tO\n54th\tO\n,\tO\nSpringer\tT-0\n64th\tO\n,\tO\nSobotzik\tO\n67th\tO\npenalty\tO\n)\tO\nSchalke\tO\n4\tO\n(\tO\nMax\tO\n11th\tO\n,\tO\nThon\tO\n34th\tO\n,\tO\nWilmots\tO\n38th\tO\n,\tO\nSpringer\tO\n64th\tO\n)\tO\n.\tO\n\nSt\tT-0\nPauli\tT-0\n4\tO\n(\tO\nDriller\tO\n15th\tO\n,\tO\nTrulsen\tB-PER\n54th\tO\n,\tO\nSpringer\tO\n64th\tO\n,\tO\nSobotzik\tO\n67th\tO\npenalty\tO\n)\tO\nSchalke\tO\n4\tO\n(\tO\nMax\tO\n11th\tO\n,\tO\nThon\tO\n34th\tO\n,\tO\nWilmots\tO\n38th\tO\n,\tO\nSpringer\tO\n64th\tO\n)\tO\n.\tO\n\nSt\tT-1\nPauli\tT-1\n4\tO\n(\tO\nDriller\tO\n15th\tO\n,\tO\nTrulsen\tO\n54th\tO\n,\tO\nSpringer\tB-PER\n64th\tO\n,\tO\nSobotzik\tO\n67th\tO\npenalty\tT-0\n)\tO\nSchalke\tT-2\n4\tO\n(\tO\nMax\tT-3\n11th\tO\n,\tO\nThon\tO\n34th\tO\n,\tO\nWilmots\tO\n38th\tO\n,\tO\nSpringer\tO\n64th\tO\n)\tO\n.\tO\n\nSt\tO\nPauli\tO\n4\tO\n(\tO\nDriller\tO\n15th\tO\n,\tO\nTrulsen\tO\n54th\tO\n,\tO\nSpringer\tO\n64th\tO\n,\tO\nSobotzik\tB-PER\n67th\tT-2\npenalty\tT-0\n)\tO\nSchalke\tT-1\n4\tO\n(\tO\nMax\tO\n11th\tO\n,\tO\nThon\tO\n34th\tO\n,\tO\nWilmots\tO\n38th\tO\n,\tO\nSpringer\tO\n64th\tO\n)\tO\n.\tO\n\nSt\tO\nPauli\tO\n4\tO\n(\tO\nDriller\tO\n15th\tO\n,\tO\nTrulsen\tO\n54th\tO\n,\tO\nSpringer\tO\n64th\tO\n,\tO\nSobotzik\tO\n67th\tO\npenalty\tO\n)\tO\nSchalke\tB-ORG\n4\tT-0\n(\tO\nMax\tT-1\n11th\tT-1\n,\tO\nThon\tT-2\n34th\tT-2\n,\tO\nWilmots\tT-3\n38th\tT-3\n,\tO\nSpringer\tT-4\n64th\tT-4\n)\tO\n.\tO\n\nSt\tT-0\nPauli\tT-0\n4\tO\n(\tO\nDriller\tO\n15th\tO\n,\tO\nTrulsen\tO\n54th\tO\n,\tO\nSpringer\tO\n64th\tO\n,\tO\nSobotzik\tO\n67th\tO\npenalty\tO\n)\tO\nSchalke\tO\n4\tO\n(\tO\nMax\tB-PER\n11th\tO\n,\tO\nThon\tO\n34th\tO\n,\tO\nWilmots\tO\n38th\tO\n,\tO\nSpringer\tO\n64th\tO\n)\tO\n.\tO\n\nSt\tT-0\nPauli\tT-0\n4\tT-0\n(\tO\nDriller\tO\n15th\tO\n,\tO\nTrulsen\tT-2\n54th\tT-2\n,\tO\nSpringer\tO\n64th\tO\n,\tO\nSobotzik\tO\n67th\tO\npenalty\tO\n)\tO\nSchalke\tT-3\n4\tT-3\n(\tO\nMax\tO\n11th\tO\n,\tO\nThon\tB-PER\n34th\tT-1\n,\tO\nWilmots\tO\n38th\tO\n,\tO\nSpringer\tO\n64th\tO\n)\tO\n.\tO\n\nSt\tO\nPauli\tO\n4\tO\n(\tO\nDriller\tO\n15th\tO\n,\tO\nTrulsen\tO\n54th\tO\n,\tO\nSpringer\tO\n64th\tO\n,\tO\nSobotzik\tO\n67th\tO\npenalty\tO\n)\tO\nSchalke\tO\n4\tO\n(\tO\nMax\tO\n11th\tO\n,\tO\nThon\tO\n34th\tO\n,\tO\nWilmots\tB-PER\n38th\tT-0\n,\tO\nSpringer\tO\n64th\tO\n)\tO\n.\tO\n\nSt\tT-0\nPauli\tT-0\n4\tO\n(\tO\nDriller\tO\n15th\tO\n,\tO\nTrulsen\tO\n54th\tO\n,\tO\nSpringer\tO\n64th\tO\n,\tO\nSobotzik\tO\n67th\tO\npenalty\tO\n)\tO\nSchalke\tO\n4\tO\n(\tO\nMax\tO\n11th\tO\n,\tO\nThon\tO\n34th\tO\n,\tO\nWilmots\tO\n38th\tO\n,\tO\nSpringer\tB-PER\n64th\tO\n)\tO\n.\tO\n\nSOCCER\tO\n-\tO\nFRENCH\tB-MISC\nLEAGUE\tT-0\nSUMMARY\tT-0\n.\tO\n\nSummary\tO\nof\tO\na\tO\nFrench\tB-MISC\nfirst\tO\ndivision\tT-0\nmatch\tT-1\non\tO\nFriday\tO\n.\tO\n\nNancy\tB-ORG\n0\tO\nParis\tT-0\nSt\tT-0\nGermain\tT-0\n0\tO\n.\tO\n\nNancy\tO\n0\tO\nParis\tB-ORG\nSt\tI-ORG\nGermain\tI-ORG\n0\tT-0\n.\tO\n\nSOCCER\tO\n-\tO\nFRENCH\tB-MISC\nLEAGUE\tT-0\nRESULT\tT-0\n.\tO\n\nResult\tT-1\nof\tO\na\tO\nFrench\tB-MISC\nfirst\tO\ndivision\tO\nmatch\tT-0\non\tO\nFriday\tO\n.\tO\n\nNancy\tB-ORG\n0\tO\nParis\tT-0\nSt\tO\nGermain\tT-1\n0\tO\n\nNancy\tT-0\n0\tT-0\nParis\tB-ORG\nSt\tI-ORG\nGermain\tI-ORG\n0\tO\n\nSOCCER\tT-2\n-\tO\nGERMAN\tB-MISC\nFIRST\tO\nDIVISION\tT-0\nRESULTS\tT-1\n.\tO\n\nResults\tT-0\nof\tO\nGerman\tB-MISC\nfirst\tO\ndivision\tO\n\nSt\tB-ORG\nPauli\tI-ORG\n4\tT-0\nSchalke\tT-1\n4\tT-2\n\nSt\tT-0\nPauli\tT-0\n4\tO\nSchalke\tB-ORG\n4\tO\n\nHansa\tO\nRostock\tT-0\n0\tO\nHamburg\tB-ORG\n1\tO\n\nATHLETICS\tT-0\n-\tO\nMASTERKOVA\tB-PER\nBREAKS\tT-1\nSECOND\tO\nWORLD\tO\nRECORD\tO\nIN\tO\n10\tO\nDAYS\tO\n.\tO\n\nRussia\tB-LOC\n's\tO\ndouble\tO\nOlympic\tT-3\nchampion\tO\nSvetlana\tO\nMasterkova\tO\nsmashed\tT-0\nher\tO\nsecond\tO\nworld\tO\nrecord\tT-1\nin\tO\njust\tO\n10\tO\ndays\tO\non\tO\nFriday\tO\nwhen\tO\nshe\tO\nbettered\tT-2\nthe\tO\nmark\tO\nfor\tO\nthe\tO\nwomen\tO\n's\tO\n1,000\tO\nmetres\tO\n.\tO\n\nRussia\tT-3\n's\tO\ndouble\tT-0\nOlympic\tB-MISC\nchampion\tT-1\nSvetlana\tT-4\nMasterkova\tT-4\nsmashed\tO\nher\tO\nsecond\tO\nworld\tO\nrecord\tT-2\nin\tO\njust\tO\n10\tO\ndays\tO\non\tO\nFriday\tO\nwhen\tO\nshe\tO\nbettered\tO\nthe\tO\nmark\tO\nfor\tO\nthe\tO\nwomen\tO\n's\tO\n1,000\tO\nmetres\tO\n.\tO\n\nRussia\tO\n's\tO\ndouble\tO\nOlympic\tO\nchampion\tT-1\nSvetlana\tB-PER\nMasterkova\tI-PER\nsmashed\tT-2\nher\tT-3\nsecond\tO\nworld\tO\nrecord\tO\nin\tO\njust\tO\n10\tO\ndays\tO\non\tO\nFriday\tO\nwhen\tO\nshe\tO\nbettered\tT-0\nthe\tO\nmark\tO\nfor\tO\nthe\tO\nwomen\tO\n's\tO\n1,000\tO\nmetres\tO\n.\tO\n\nAfter\tO\nbreaking\tO\nthe\tO\nworld\tO\nrecord\tO\nfor\tO\nthe\tO\nwomen\tT-3\n's\tT-3\nmile\tT-3\nin\tT-0\nZurich\tB-LOC\nlast\tO\nWednesday\tO\n,\tO\nthe\tO\nOlympic\tO\n800\tO\nand\tO\n1,500\tO\nmetres\tO\nchampion\tO\nclocked\tT-1\ntwo\tO\nminutes\tO\n28.98\tO\nseconds\tO\nover\tO\n1,000\tO\nat\tO\nthe\tO\nBrussels\tT-2\ngrand\tO\nprix\tO\nmeeting\tO\n.\tO\n\nAfter\tO\nbreaking\tO\nthe\tO\nworld\tT-0\nrecord\tT-0\nfor\tO\nthe\tO\nwomen\tO\n's\tO\nmile\tO\nin\tO\nZurich\tT-2\nlast\tO\nWednesday\tO\n,\tO\nthe\tO\nOlympic\tB-MISC\n800\tO\nand\tO\n1,500\tO\nmetres\tO\nchampion\tO\nclocked\tO\ntwo\tO\nminutes\tO\n28.98\tO\nseconds\tO\nover\tO\n1,000\tO\nat\tO\nthe\tO\nBrussels\tO\ngrand\tT-1\nprix\tT-1\nmeeting\tO\n.\tO\n\nAfter\tO\nbreaking\tO\nthe\tO\nworld\tO\nrecord\tO\nfor\tO\nthe\tO\nwomen\tO\n's\tO\nmile\tO\nin\tO\nZurich\tT-0\nlast\tO\nWednesday\tO\n,\tO\nthe\tO\nOlympic\tO\n800\tO\nand\tO\n1,500\tO\nmetres\tO\nchampion\tO\nclocked\tO\ntwo\tO\nminutes\tO\n28.98\tO\nseconds\tO\nover\tO\n1,000\tO\nat\tT-2\nthe\tT-2\nBrussels\tB-LOC\ngrand\tT-1\nprix\tT-1\nmeeting\tT-1\n.\tO\n\nThe\tT-1\nRussian\tB-MISC\nate\tO\nup\tO\nthe\tO\nground\tT-2\nin\tO\na\tO\nswift\tO\nlast\tO\nlap\tT-0\nto\tO\nshave\tO\n0.36\tO\nseconds\tO\noff\tO\nthe\tO\nprevious\tO\nbest\tO\nof\tO\n2:29.34\tO\nset\tO\nby\tO\nMozambique\tO\n's\tO\nMaria\tO\nMutola\tO\nin\tO\nthe\tO\nsame\tO\nstadium\tT-3\nin\tO\nAugust\tO\nlast\tO\nyear\tO\n.\tO\n\nThe\tO\nRussian\tT-2\nate\tO\nup\tO\nthe\tO\nground\tO\nin\tO\na\tO\nswift\tO\nlast\tO\nlap\tO\nto\tO\nshave\tO\n0.36\tO\nseconds\tO\noff\tO\nthe\tO\nprevious\tO\nbest\tO\nof\tO\n2:29.34\tO\nset\tT-1\nby\tT-1\nMozambique\tB-LOC\n's\tO\nMaria\tO\nMutola\tO\nin\tO\nthe\tO\nsame\tO\nstadium\tT-0\nin\tO\nAugust\tO\nlast\tO\nyear\tO\n.\tO\n\nThe\tO\nRussian\tT-3\nate\tO\nup\tO\nthe\tO\nground\tO\nin\tO\na\tO\nswift\tO\nlast\tO\nlap\tO\nto\tO\nshave\tO\n0.36\tO\nseconds\tO\noff\tO\nthe\tO\nprevious\tT-0\nbest\tT-0\nof\tO\n2:29.34\tO\nset\tT-1\nby\tO\nMozambique\tT-2\n's\tO\nMaria\tB-PER\nMutola\tI-PER\nin\tO\nthe\tO\nsame\tO\nstadium\tO\nin\tO\nAugust\tO\nlast\tO\nyear\tO\n.\tO\n\nFormer\tO\nworld\tO\n800\tO\nchampion\tO\nMutola\tB-PER\npushed\tO\nMasterkova\tT-0\nall\tO\nthe\tO\nway\tO\n,\tO\nfinishing\tO\nsecond\tO\nin\tO\n2:29.66\tO\n.\tO\n\nFormer\tO\nworld\tO\n800\tO\nchampion\tO\nMutola\tO\npushed\tO\nMasterkova\tB-PER\nall\tT-0\nthe\tT-0\nway\tT-0\n,\tO\nfinishing\tT-1\nsecond\tO\nin\tO\n2:29.66\tO\n.\tO\n\nBut\tO\nit\tO\nwas\tO\nthe\tO\nRussian\tB-MISC\nwho\tO\npicked\tO\nup\tO\nthe\tO\nbonus\tT-0\nof\tO\n$\tO\n25,000\tO\nfor\tO\nthe\tO\nhistoric\tT-1\nrun\tT-1\nin\tO\nfront\tO\nof\tO\na\tO\ncapacity\tO\n40,000\tO\ncrowd\tO\n.\tO\n\nMasterkova\tB-PER\ndominated\tT-1\nthe\tO\nmiddle-distance\tO\nraces\tO\nat\tO\nthe\tO\nrecent\tO\nAtlanta\tT-3\nGames\tT-0\nfollowing\tO\nher\tO\nreturn\tT-2\nto\tO\ncompetition\tO\nthis\tO\nseason\tO\nafter\tO\na\tO\nthree-year\tO\nmaternity\tT-4\nbreak\tO\n.\tO\n\nMasterkova\tO\ndominated\tO\nthe\tO\nmiddle-distance\tO\nraces\tO\nat\tO\nthe\tO\nrecent\tT-0\nAtlanta\tB-MISC\nGames\tI-MISC\nfollowing\tO\nher\tO\nreturn\tO\nto\tO\ncompetition\tO\nthis\tO\nseason\tO\nafter\tO\na\tO\nthree-year\tO\nmaternity\tO\nbreak\tO\n.\tO\n\nIn\tO\nher\tO\nfirst\tO\nmile\tO\nrace\tO\nat\tO\nthe\tO\nrichest\tO\nmeeting\tT-1\nin\tT-0\nZurich\tB-LOC\nlast\tO\nWednesday\tO\n,\tO\nshe\tO\nslashed\tO\n3.05\tT-2\nseconds\tO\noff\tO\nthe\tO\nprevious\tO\nrecord\tO\n.\tO\n\nThe\tO\nrecord\tO\nof\tO\nfour\tO\nminutes\tO\n,\tO\n12.56\tT-0\nseconds\tT-0\nin\tO\nZurich\tB-LOC\nearned\tT-3\nMasterkova\tT-2\na\tO\nbonus\tO\nof\tO\n$\tO\n50,000\tO\nplus\tO\none\tO\nkilo\tO\nof\tO\ngold\tO\n.\tO\n\nThe\tT-0\nrecord\tT-0\nof\tO\nfour\tO\nminutes\tO\n,\tO\n12.56\tO\nseconds\tO\nin\tO\nZurich\tT-1\nearned\tO\nMasterkova\tB-PER\na\tO\nbonus\tO\nof\tO\n$\tO\n50,000\tO\nplus\tO\none\tO\nkilo\tO\nof\tO\ngold\tO\n.\tO\n\nAfter\tO\nFriday\tO\n's\tO\nperformance\tT-0\nthe\tO\nRussian\tB-MISC\nwill\tO\nhave\tO\nearned\tT-1\nwell\tO\nover\tO\n$\tO\n100,000\tO\nin\tO\nless\tO\nthan\tO\na\tO\nfortnight\tO\n,\tO\ntaking\tO\nher\tO\nappearance\tO\nmoney\tO\ninto\tO\naccount\tO\n.\tO\n\nBrussels\tB-LOC\norganisers\tO\nhad\tO\nlaid\tT-1\na\tO\nnew\tO\ntrack\tT-0\nfor\tO\nthe\tO\nmeeting\tO\ncomparable\tO\nto\tO\nthe\tO\nsurface\tO\nat\tO\nthe\tO\nAtlanta\tO\nGames\tO\nbut\tO\nput\tO\ndown\tO\non\tO\na\tO\nsofter\tO\nsurface\tO\n.\tO\n\nBrussels\tT-0\norganisers\tT-0\nhad\tO\nlaid\tO\na\tO\nnew\tO\ntrack\tT-1\nfor\tO\nthe\tO\nmeeting\tO\ncomparable\tO\nto\tO\nthe\tO\nsurface\tT-3\nat\tT-3\nthe\tT-3\nAtlanta\tB-MISC\nGames\tI-MISC\nbut\tO\nput\tT-4\ndown\tT-4\non\tO\na\tO\nsofter\tO\nsurface\tT-2\n.\tO\n\nMasterkova\tB-PER\nclearly\tO\nenjoyed\tT-0\nit\tO\n.\tO\n\nMutola\tB-PER\nlooked\tO\nthreatening\tO\nin\tO\nthe\tO\nfinal\tO\n200\tT-1\nmetres\tT-1\nbut\tO\nthe\tO\nRussian\tT-2\nfound\tT-2\nan\tT-2\nextra\tT-2\ngear\tT-2\nto\tO\npower\tO\nhome\tO\nseveral\tO\nstrides\tO\nahead\tO\n,\tO\npointing\tO\nat\tO\nthe\tO\ntime\tO\non\tO\nthe\tO\nclock\tO\nwith\tO\ndelight\tO\nas\tO\nshe\tT-0\ncrossed\tO\nthe\tO\nline\tO\n.\tO\n\nMutola\tT-1\nlooked\tT-2\nthreatening\tO\nin\tO\nthe\tO\nfinal\tO\n200\tT-0\nmetres\tT-0\nbut\tO\nthe\tO\nRussian\tB-MISC\nfound\tT-3\nan\tO\nextra\tO\ngear\tO\nto\tO\npower\tO\nhome\tO\nseveral\tO\nstrides\tO\nahead\tO\n,\tO\npointing\tO\nat\tO\nthe\tO\ntime\tO\non\tO\nthe\tO\nclock\tO\nwith\tO\ndelight\tO\nas\tO\nshe\tO\ncrossed\tO\nthe\tO\nline\tO\n.\tO\n\n2:30.67\tO\nChristine\tB-PER\nWachtel\tI-PER\n(\tO\nGermany\tO\n)\tO\nBerlin\tT-0\n17.8.90\tO\n\n2:30.67\tO\nChristine\tO\nWachtel\tO\n(\tO\nGermany\tB-LOC\n)\tO\nBerlin\tT-0\n17.8.90\tO\n\n2:30.67\tO\nChristine\tT-0\nWachtel\tT-0\n(\tO\nGermany\tT-1\n)\tO\nBerlin\tB-LOC\n17.8.90\tO\n\n2:29.34\tO\nMaria\tB-PER\nMutola\tI-PER\n(\tO\nMozambique\tT-0\n)\tO\nBrussels\tO\n25.8.95\tO\n\n2:29.34\tO\nMaria\tO\nMutola\tO\n(\tO\nMozambique\tB-LOC\n)\tT-0\nBrussels\tT-0\n25.8.95\tO\n\n2:29.34\tO\nMaria\tO\nMutola\tT-0\n(\tO\nMozambique\tO\n)\tO\nBrussels\tB-LOC\n25.8.95\tO\n\n2:28.98\tT-1\nSvetlana\tB-PER\nMasterkova\tI-PER\n(\tO\nRussia\tO\n)\tO\nBrussels\tT-0\n23.8.96\tO\n\n2:28.98\tO\nSvetlana\tO\nMasterkova\tO\n(\tO\nRussia\tB-LOC\n)\tO\nBrussels\tT-0\n23.8.96\tO\n\n2:28.98\tO\nSvetlana\tT-1\nMasterkova\tT-1\n(\tO\nRussia\tT-2\n)\tO\nBrussels\tB-LOC\n23.8.96\tO\n\nATHLETICS\tT-1\n-\tO\nMASTERKOVA\tB-PER\nBREAKS\tO\nWOMEN\tT-0\n'S\tO\nWORLD\tO\n1,000\tO\nRECORD\tO\n.\tO\n\nRussian\tB-MISC\nSvetlana\tT-3\nMasterkova\tO\nbroke\tT-0\nthe\tT-0\nwomen\tT-1\n's\tT-1\nworld\tT-1\n1,000\tT-1\nmetres\tT-1\nrecord\tO\non\tO\nFriday\tO\nwhen\tO\nshe\tO\nclocked\tT-2\nan\tO\nunofficial\tO\ntwo\tO\nminutes\tO\n28.99\tO\nseconds\tO\nat\tO\nthe\tO\nBrussels\tO\ngrand\tO\nprix\tO\n.\tO\n\nRussian\tT-0\nSvetlana\tB-PER\nMasterkova\tI-PER\nbroke\tT-1\nthe\tO\nwomen\tT-3\n's\tT-3\nworld\tT-3\n1,000\tO\nmetres\tO\nrecord\tO\non\tO\nFriday\tO\nwhen\tO\nshe\tO\nclocked\tT-2\nan\tO\nunofficial\tO\ntwo\tO\nminutes\tO\n28.99\tO\nseconds\tO\nat\tO\nthe\tO\nBrussels\tT-4\ngrand\tO\nprix\tO\n.\tO\n\nRussian\tO\nSvetlana\tO\nMasterkova\tO\nbroke\tT-1\nthe\tO\nwomen\tO\n's\tO\nworld\tO\n1,000\tO\nmetres\tO\nrecord\tO\non\tO\nFriday\tO\nwhen\tO\nshe\tO\nclocked\tO\nan\tO\nunofficial\tO\ntwo\tO\nminutes\tO\n28.99\tO\nseconds\tO\nat\tT-2\nthe\tT-2\nBrussels\tB-LOC\ngrand\tT-0\nprix\tT-0\n.\tO\n\nThe\tO\nprevious\tO\nmark\tO\nof\tO\n2:29.34\tT-0\nwas\tO\nset\tO\nby\tO\nMozambique\tB-LOC\n's\tO\nMaria\tT-1\nMutola\tT-1\nhere\tO\non\tO\nAugust\tO\n25\tO\nlast\tO\nyear\tO\n.\tO\n\nThe\tO\nprevious\tT-2\nmark\tO\nof\tO\n2:29.34\tT-0\nwas\tO\nset\tO\nby\tO\nMozambique\tT-1\n's\tT-1\nMaria\tB-PER\nMutola\tI-PER\nhere\tO\non\tO\nAugust\tO\n25\tO\nlast\tO\nyear\tO\n.\tO\n\nGOLF\tO\n-\tO\nGERMAN\tB-MISC\nOPEN\tI-MISC\nSECOND\tO\nROUND\tT-0\nSCORES\tO\n.\tO\n\nSTUTTGART\tB-LOC\n,\tO\nGermany\tT-0\n1996-08-23\tO\n\nSTUTTGART\tT-0\n,\tO\nGermany\tB-LOC\n1996-08-23\tO\n\nscores\tT-1\nin\tO\nthe\tO\nGerman\tB-MISC\nOpen\tI-MISC\ngolf\tT-0\nchampionship\tT-2\non\tO\nFriday\tO\n(\tO\nBritain\tO\n\nscores\tO\nin\tO\nthe\tO\nGerman\tT-1\nOpen\tT-1\ngolf\tT-1\nchampionship\tT-0\non\tO\nFriday\tO\n(\tO\nBritain\tB-LOC\n\n128\tO\nIan\tB-PER\nWoosnam\tI-PER\n64\tT-0\n64\tT-0\n\n130\tO\nFernando\tB-PER\nRoca\tI-PER\n(\tO\nSpain\tT-0\n)\tO\n66\tO\n64\tO\n,\tO\nIan\tO\nPyman\tO\n66\tO\n64\tO\n\n131\tO\nCarl\tB-PER\nSuneson\tI-PER\n65\tT-0\n66\tT-0\n,\tO\nStephen\tO\nField\tO\n66\tT-1\n65\tT-1\n\n132\tT-0\nMiguel\tT-0\nAngel\tT-0\nMartin\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n66\tO\n66\tO\n,\tO\nRaymond\tO\nRussell\tO\n63\tO\n69\tO\n,\tO\n\n132\tO\nMiguel\tO\nAngel\tO\nMartin\tO\n(\tO\nSpain\tO\n)\tO\n66\tT-0\n66\tT-0\n,\tO\nRaymond\tB-PER\nRussell\tI-PER\n63\tO\n69\tO\n,\tO\n\nThomas\tB-PER\nGogele\tI-PER\n(\tO\nGermany\tO\n)\tO\n67\tO\n65\tO\n,\tO\nPaul\tT-0\nBroadhurst\tT-0\n62\tO\n70\tO\n,\tO\n\nThomas\tT-0\nGogele\tO\n(\tO\nGermany\tO\n)\tO\n67\tO\n65\tO\n,\tO\nPaul\tB-PER\nBroadhurst\tI-PER\n62\tO\n70\tO\n,\tO\n\nDiego\tB-PER\nBorrego\tI-PER\n(\tO\nSpain\tT-0\n)\tO\n69\tO\n63\tO\n\nDiego\tT-0\nBorrego\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n69\tO\n63\tO\n\n133\tO\nRicky\tO\nWillison\tO\n69\tO\n64\tO\n,\tO\nStephen\tB-PER\nAmes\tI-PER\n(\tO\nTrinidad\tT-0\nand\tT-0\nTobago\tT-0\n)\tO\n\n68\tO\n65\tO\n,\tO\nEamonn\tB-PER\nDarcy\tI-PER\n(\tO\nIreland\tT-0\n)\tO\n65\tT-1\n68\tT-1\n\n68\tO\n65\tO\n,\tO\nEamonn\tT-0\nDarcy\tT-0\n(\tO\nIreland\tB-LOC\n)\tO\n65\tO\n68\tO\n\n134\tO\nRobert\tB-PER\nColes\tI-PER\n68\tT-0\n66\tT-0\n,\tO\nDavid\tT-1\nWilliams\tT-1\n67\tO\n67\tO\n,\tO\nThomas\tO\nBjorn\tO\n\n134\tO\nRobert\tT-0\nColes\tT-0\n68\tO\n66\tO\n,\tO\nDavid\tB-PER\nWilliams\tI-PER\n67\tO\n67\tO\n,\tO\nThomas\tO\nBjorn\tO\n\n134\tO\nRobert\tO\nColes\tO\n68\tO\n66\tO\n,\tO\nDavid\tT-0\nWilliams\tT-0\n67\tO\n67\tO\n,\tO\nThomas\tB-PER\nBjorn\tI-PER\n\n(\tO\nDenmark\tB-LOC\n)\tO\n66\tT-0\n68\tT-0\n,\tO\nPedro\tT-1\nLinhart\tT-1\n(\tO\nSpain\tO\n)\tO\n67\tO\n67\tO\n,\tO\nMichael\tO\n\n(\tO\nDenmark\tO\n)\tO\n66\tO\n68\tO\n,\tO\nPedro\tB-PER\nLinhart\tI-PER\n(\tO\nSpain\tO\n)\tO\n67\tO\n67\tO\n,\tO\nMichael\tT-0\n\n(\tO\nDenmark\tO\n)\tO\n66\tO\n68\tO\n,\tO\nPedro\tT-0\nLinhart\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n67\tO\n67\tO\n,\tO\nMichael\tO\n\n(\tO\nDenmark\tO\n)\tO\n66\tT-0\n68\tT-0\n,\tO\nPedro\tT-2\nLinhart\tT-2\n(\tO\nSpain\tO\n)\tO\n67\tT-1\n67\tT-1\n,\tO\nMichael\tB-PER\n\nJonzon\tB-PER\n(\tO\nSweden\tO\n)\tO\n67\tO\n67\tO\n,\tO\nRoger\tT-0\nChapman\tT-0\n72\tO\n62\tO\n,\tO\nJonathan\tT-1\nLomas\tT-1\n\nJonzon\tT-0\n(\tO\nSweden\tB-LOC\n)\tO\n67\tT-1\n67\tT-1\n,\tO\nRoger\tO\nChapman\tO\n72\tT-2\n62\tT-2\n,\tO\nJonathan\tO\nLomas\tO\n\nJonzon\tO\n(\tO\nSweden\tO\n)\tO\n67\tO\n67\tO\n,\tO\nRoger\tB-PER\nChapman\tI-PER\n72\tT-0\n62\tT-0\n,\tO\nJonathan\tO\nLomas\tO\n\nJonzon\tT-0\n(\tO\nSweden\tO\n)\tO\n67\tO\n67\tO\n,\tO\nRoger\tO\nChapman\tO\n72\tO\n62\tO\n,\tO\nJonathan\tB-PER\nLomas\tI-PER\n\n67\tO\n67\tO\n,\tO\nFrancisco\tB-PER\nCea\tI-PER\n(\tO\nSpain\tT-0\n)\tO\n68\tO\n66\tO\n\n67\tO\n67\tO\n,\tO\nFrancisco\tT-0\nCea\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n68\tO\n66\tO\n\n135\tO\nTerry\tB-PER\nPrice\tI-PER\n(\tO\nAustralia\tT-1\n)\tO\n67\tO\n68\tO\n,\tO\nPaul\tT-0\nEales\tT-0\n67\tO\n68\tO\n,\tO\nWayne\tO\n\n135\tO\nTerry\tT-0\nPrice\tO\n(\tO\nAustralia\tB-LOC\n)\tO\n67\tO\n68\tO\n,\tO\nPaul\tO\nEales\tO\n67\tO\n68\tO\n,\tO\nWayne\tO\n\n135\tT-0\nTerry\tT-2\nPrice\tT-2\n(\tO\nAustralia\tO\n)\tO\n67\tO\n68\tO\n,\tO\nPaul\tB-PER\nEales\tI-PER\n67\tT-1\n68\tT-1\n,\tO\nWayne\tO\n\nRiley\tB-PER\n(\tO\nAustralia\tT-0\n)\tO\n64\tO\n71\tO\n,\tO\nCarl\tT-1\nMason\tT-1\n69\tO\n66\tO\n,\tO\nBarry\tO\nLane\tO\n\nRiley\tT-0\n(\tO\nAustralia\tB-LOC\n)\tO\n64\tO\n71\tO\n,\tO\nCarl\tO\nMason\tO\n69\tO\n66\tO\n,\tO\nBarry\tO\nLane\tO\n\nRiley\tT-0\n(\tO\nAustralia\tO\n)\tO\n64\tT-1\n71\tT-1\n,\tO\nCarl\tB-PER\nMason\tI-PER\n69\tO\n66\tO\n,\tO\nBarry\tT-2\nLane\tT-2\n\nRiley\tT-0\n(\tO\nAustralia\tO\n)\tO\n64\tO\n71\tO\n,\tO\nCarl\tO\nMason\tO\n69\tO\n66\tO\n,\tO\nBarry\tB-PER\nLane\tI-PER\n\n68\tO\n67\tO\n,\tO\nBernhard\tB-PER\nLanger\tI-PER\n(\tO\nGermany\tT-1\n)\tO\n64\tO\n71\tO\n,\tO\nGary\tT-2\nOrr\tT-2\n67\tO\n68\tO\n,\tO\n\n68\tO\n67\tO\n,\tO\nBernhard\tO\nLanger\tO\n(\tO\nGermany\tO\n)\tO\n64\tO\n71\tO\n,\tO\nGary\tB-PER\nOrr\tI-PER\n67\tT-0\n68\tT-0\n,\tT-0\n\nMats\tB-PER\nLanner\tI-PER\n(\tO\nSweden\tO\n)\tO\n64\tO\n71\tO\n,\tO\nJeff\tT-0\nHawksworth\tT-0\n67\tO\n68\tO\n,\tO\nDes\tO\n\nMats\tT-1\nLanner\tT-1\n(\tO\nSweden\tO\n)\tO\n64\tO\n71\tO\n,\tO\nJeff\tB-PER\nHawksworth\tI-PER\n67\tT-0\n68\tT-0\n,\tO\nDes\tO\n\nMats\tO\nLanner\tO\n(\tO\nSweden\tO\n)\tO\n64\tO\n71\tO\n,\tO\nJeff\tT-0\nHawksworth\tT-0\n67\tO\n68\tO\n,\tO\nDes\tB-PER\n\nSmyth\tT-0\n(\tO\nIreland\tB-LOC\n)\tO\n66\tO\n69\tO\n,\tO\nDavid\tO\nCarter\tO\n66\tO\n69\tO\n,\tO\nSteve\tO\nWebster\tO\n\nSmyth\tT-0\n(\tO\nIreland\tO\n)\tO\n66\tO\n69\tO\n,\tO\nDavid\tB-PER\nCarter\tI-PER\n66\tO\n69\tO\n,\tO\nSteve\tT-1\nWebster\tT-1\n\nSmyth\tT-0\n(\tO\nIreland\tT-1\n)\tO\n66\tO\n69\tO\n,\tO\nDavid\tO\nCarter\tO\n66\tO\n69\tO\n,\tO\nSteve\tB-PER\nWebster\tI-PER\n\n69\tO\n66\tO\n,\tO\nJose\tB-PER\nMaria\tI-PER\nCanizares\tI-PER\n(\tO\nSpain\tO\n)\tO\n67\tT-0\n68\tT-0\n,\tO\nPaul\tO\nLawrie\tO\n\n69\tO\n66\tO\n,\tO\nJose\tO\nMaria\tO\nCanizares\tO\n(\tO\nSpain\tB-LOC\n)\tO\n67\tT-0\n68\tT-0\n,\tO\nPaul\tO\nLawrie\tO\n\n69\tO\n66\tO\n,\tO\nJose\tT-0\nMaria\tT-0\nCanizares\tT-1\n(\tO\nSpain\tO\n)\tO\n67\tO\n68\tO\n,\tO\nPaul\tB-PER\nLawrie\tI-PER\n\nATHLETICS\tO\n-\tO\nMITCHELL\tO\nUPSTAGES\tO\nTRIO\tT-0\nOF\tT-0\nOLYMPIC\tB-MISC\nSPRINT\tO\nCHAMPIONS\tT-1\n.\tO\n\nAmerican\tB-MISC\nDennis\tT-0\nMitchell\tO\nupstaged\tO\na\tO\ntrio\tO\nof\tO\npast\tO\nand\tO\npresent\tT-1\nOlympic\tO\n100\tO\nmetres\tO\nchampions\tO\non\tO\nFriday\tO\nwith\tO\na\tO\nstorming\tO\nvictory\tO\nat\tO\nthe\tO\nBrussels\tO\ngrand\tO\nprix\tO\n.\tO\n\nAmerican\tO\nDennis\tB-PER\nMitchell\tI-PER\nupstaged\tO\na\tO\ntrio\tO\nof\tO\npast\tO\nand\tO\npresent\tO\nOlympic\tO\n100\tO\nmetres\tO\nchampions\tO\non\tO\nFriday\tO\nwith\tO\na\tO\nstorming\tO\nvictory\tT-0\nat\tO\nthe\tO\nBrussels\tO\ngrand\tO\nprix\tO\n.\tO\n\nAmerican\tT-1\nDennis\tT-2\nMitchell\tT-2\nupstaged\tO\na\tO\ntrio\tO\nof\tO\npast\tO\nand\tO\npresent\tT-0\nOlympic\tB-MISC\n100\tO\nmetres\tO\nchampions\tO\non\tO\nFriday\tO\nwith\tO\na\tO\nstorming\tO\nvictory\tO\nat\tO\nthe\tO\nBrussels\tO\ngrand\tO\nprix\tO\n.\tO\n\nAmerican\tO\nDennis\tT-0\nMitchell\tT-0\nupstaged\tO\na\tO\ntrio\tO\nof\tO\npast\tO\nand\tO\npresent\tO\nOlympic\tT-1\n100\tO\nmetres\tO\nchampions\tO\non\tO\nFriday\tO\nwith\tO\na\tO\nstorming\tO\nvictory\tO\nat\tO\nthe\tO\nBrussels\tB-LOC\ngrand\tO\nprix\tO\n.\tO\n\nSporting\tB-ORG\nhis\tO\ncustomary\tO\nbright\tO\ngreen\tO\noutfit\tT-0\n,\tO\nthe\tO\nU.S.\tO\nchampion\tO\nclocked\tT-3\n10.03\tO\nseconds\tO\ndespite\tO\ndamp\tO\nconditions\tO\nto\tO\ntake\tO\nthe\tO\nscalp\tO\nof\tO\nCanada\tO\n's\tO\nreigning\tO\nOlympic\tT-2\nchampion\tT-1\nDonovan\tO\nBailey\tO\n,\tO\n1992\tO\nchampion\tO\nLinford\tO\nChristie\tO\nof\tO\nBritain\tO\nand\tO\nAmerican\tO\n1984\tO\nand\tO\n1988\tO\nchampion\tO\nCarl\tO\nLewis\tO\n.\tO\n\nSporting\tO\nhis\tO\ncustomary\tT-1\nbright\tO\ngreen\tO\noutfit\tO\n,\tO\nthe\tT-2\nU.S.\tB-LOC\nchampion\tT-0\nclocked\tO\n10.03\tO\nseconds\tO\ndespite\tO\ndamp\tT-3\nconditions\tT-3\nto\tO\ntake\tO\nthe\tO\nscalp\tO\nof\tO\nCanada\tO\n's\tO\nreigning\tO\nOlympic\tO\nchampion\tO\nDonovan\tO\nBailey\tO\n,\tO\n1992\tO\nchampion\tO\nLinford\tO\nChristie\tO\nof\tO\nBritain\tO\nand\tO\nAmerican\tO\n1984\tO\nand\tO\n1988\tO\nchampion\tO\nCarl\tO\nLewis\tO\n.\tO\n\nSporting\tT-1\nhis\tO\ncustomary\tO\nbright\tO\ngreen\tO\noutfit\tO\n,\tO\nthe\tO\nU.S.\tO\nchampion\tT-2\nclocked\tO\n10.03\tO\nseconds\tO\ndespite\tO\ndamp\tO\nconditions\tO\nto\tO\ntake\tO\nthe\tO\nscalp\tO\nof\tO\nCanada\tB-LOC\n's\tO\nreigning\tT-0\nOlympic\tO\nchampion\tO\nDonovan\tT-4\nBailey\tT-4\n,\tO\n1992\tO\nchampion\tO\nLinford\tT-5\nChristie\tT-5\nof\tO\nBritain\tT-6\nand\tO\nAmerican\tT-3\n1984\tO\nand\tO\n1988\tO\nchampion\tO\nCarl\tO\nLewis\tO\n.\tO\n\nSporting\tO\nhis\tO\ncustomary\tO\nbright\tO\ngreen\tO\noutfit\tO\n,\tO\nthe\tO\nU.S.\tT-5\nchampion\tT-5\nclocked\tO\n10.03\tO\nseconds\tO\ndespite\tT-6\ndamp\tO\nconditions\tO\nto\tO\ntake\tO\nthe\tO\nscalp\tT-7\nof\tO\nCanada\tT-0\n's\tO\nreigning\tO\nOlympic\tB-MISC\nchampion\tO\nDonovan\tT-3\nBailey\tT-3\n,\tO\n1992\tO\nchampion\tO\nLinford\tT-4\nChristie\tT-4\nof\tO\nBritain\tT-1\nand\tO\nAmerican\tT-2\n1984\tO\nand\tO\n1988\tO\nchampion\tO\nCarl\tO\nLewis\tO\n.\tO\n\nSporting\tO\nhis\tO\ncustomary\tO\nbright\tO\ngreen\tO\noutfit\tO\n,\tO\nthe\tO\nU.S.\tO\nchampion\tO\nclocked\tT-0\n10.03\tO\nseconds\tO\ndespite\tO\ndamp\tO\nconditions\tO\nto\tO\ntake\tO\nthe\tO\nscalp\tO\nof\tO\nCanada\tO\n's\tO\nreigning\tO\nOlympic\tO\nchampion\tO\nDonovan\tB-PER\nBailey\tI-PER\n,\tO\n1992\tO\nchampion\tT-1\nLinford\tO\nChristie\tO\nof\tO\nBritain\tO\nand\tO\nAmerican\tO\n1984\tO\nand\tO\n1988\tO\nchampion\tO\nCarl\tO\nLewis\tO\n.\tO\n\nSporting\tO\nhis\tO\ncustomary\tO\nbright\tO\ngreen\tO\noutfit\tO\n,\tO\nthe\tO\nU.S.\tT-0\nchampion\tT-0\nclocked\tO\n10.03\tO\nseconds\tO\ndespite\tO\ndamp\tO\nconditions\tO\nto\tO\ntake\tO\nthe\tO\nscalp\tO\nof\tO\nCanada\tO\n's\tO\nreigning\tO\nOlympic\tO\nchampion\tO\nDonovan\tO\nBailey\tO\n,\tO\n1992\tO\nchampion\tT-1\nLinford\tB-PER\nChristie\tI-PER\nof\tT-2\nBritain\tT-3\nand\tO\nAmerican\tO\n1984\tO\nand\tO\n1988\tO\nchampion\tO\nCarl\tO\nLewis\tO\n.\tO\n\nSporting\tT-2\nhis\tO\ncustomary\tO\nbright\tO\ngreen\tO\noutfit\tT-0\n,\tO\nthe\tO\nU.S.\tO\nchampion\tO\nclocked\tO\n10.03\tO\nseconds\tO\ndespite\tO\ndamp\tO\nconditions\tO\nto\tO\ntake\tO\nthe\tO\nscalp\tT-3\nof\tO\nCanada\tO\n's\tO\nreigning\tT-1\nOlympic\tO\nchampion\tO\nDonovan\tO\nBailey\tO\n,\tO\n1992\tO\nchampion\tT-4\nLinford\tT-4\nChristie\tT-4\nof\tT-4\nBritain\tB-LOC\nand\tO\nAmerican\tO\n1984\tO\nand\tO\n1988\tO\nchampion\tO\nCarl\tO\nLewis\tO\n.\tO\n\nSporting\tO\nhis\tO\ncustomary\tO\nbright\tO\ngreen\tO\noutfit\tO\n,\tO\nthe\tO\nU.S.\tT-1\nchampion\tO\nclocked\tO\n10.03\tO\nseconds\tO\ndespite\tO\ndamp\tO\nconditions\tO\nto\tO\ntake\tO\nthe\tO\nscalp\tO\nof\tO\nCanada\tT-2\n's\tO\nreigning\tO\nOlympic\tT-5\nchampion\tT-5\nDonovan\tT-3\nBailey\tT-3\n,\tO\n1992\tO\nchampion\tT-0\nLinford\tT-0\nChristie\tO\nof\tO\nBritain\tO\nand\tO\nAmerican\tB-MISC\n1984\tO\nand\tO\n1988\tO\nchampion\tO\nCarl\tT-4\nLewis\tT-4\n.\tO\n\nSporting\tO\nhis\tO\ncustomary\tT-3\nbright\tO\ngreen\tO\noutfit\tO\n,\tO\nthe\tO\nU.S.\tT-0\nchampion\tT-0\nclocked\tO\n10.03\tO\nseconds\tO\ndespite\tO\ndamp\tO\nconditions\tO\nto\tO\ntake\tO\nthe\tO\nscalp\tO\nof\tO\nCanada\tO\n's\tO\nreigning\tO\nOlympic\tO\nchampion\tO\nDonovan\tT-1\nBailey\tT-1\n,\tO\n1992\tO\nchampion\tO\nLinford\tT-2\nChristie\tT-2\nof\tO\nBritain\tO\nand\tO\nAmerican\tO\n1984\tO\nand\tO\n1988\tO\nchampion\tT-4\nCarl\tB-PER\nLewis\tI-PER\n.\tO\n\nMitchell\tB-PER\nalso\tO\nbeat\tT-0\nworld\tO\nand\tO\nOlympic\tO\nchampion\tT-1\nBailey\tO\nat\tO\nthe\tO\nmost\tO\nlucrative\tO\nmeeting\tT-2\nin\tO\nthe\tO\nsport\tO\nin\tO\nZurich\tO\nlast\tO\nweek\tO\n.\tO\n\nMitchell\tO\nalso\tO\nbeat\tT-2\nworld\tO\nand\tO\nOlympic\tB-MISC\nchampion\tO\nBailey\tO\nat\tO\nthe\tO\nmost\tO\nlucrative\tT-3\nmeeting\tT-0\nin\tO\nthe\tO\nsport\tO\nin\tO\nZurich\tT-1\nlast\tO\nweek\tO\n.\tO\n\nMitchell\tT-0\nalso\tO\nbeat\tT-3\nworld\tO\nand\tO\nOlympic\tO\nchampion\tO\nBailey\tT-1\nat\tO\nthe\tO\nmost\tO\nlucrative\tO\nmeeting\tO\nin\tO\nthe\tO\nsport\tO\nin\tT-2\nZurich\tB-LOC\nlast\tT-4\nweek\tT-4\n.\tO\n\nThe\tO\nAmerican\tB-MISC\n,\tO\nwho\tT-0\nfinished\tO\nfourth\tO\nat\tO\nthe\tO\nAtlanta\tO\nGames\tO\n,\tO\nwas\tO\nfast\tO\nout\tO\nof\tO\nhis\tT-1\nblocks\tO\nand\tO\nheld\tO\noff\tO\nBailey\tO\n's\tO\nlate\tO\nburst\tO\nin\tO\nthe\tO\nfinal\tO\n20\tO\nmetres\tO\nbefore\tO\nheading\tO\noff\tO\nfor\tO\na\tO\nlap\tO\nof\tO\ncelebration\tO\n.\tO\n\nThe\tO\nAmerican\tO\n,\tO\nwho\tO\nfinished\tT-0\nfourth\tO\nat\tO\nthe\tO\nAtlanta\tB-MISC\nGames\tI-MISC\n,\tO\nwas\tO\nfast\tO\nout\tO\nof\tO\nhis\tO\nblocks\tT-1\nand\tO\nheld\tO\noff\tO\nBailey\tO\n's\tO\nlate\tO\nburst\tO\nin\tO\nthe\tO\nfinal\tO\n20\tO\nmetres\tO\nbefore\tO\nheading\tT-2\noff\tO\nfor\tO\na\tO\nlap\tO\nof\tO\ncelebration\tO\n.\tO\n\nThe\tO\nAmerican\tO\n,\tO\nwho\tO\nfinished\tO\nfourth\tO\nat\tO\nthe\tO\nAtlanta\tT-0\nGames\tT-0\n,\tT-0\nwas\tO\nfast\tO\nout\tT-2\nof\tT-2\nhis\tT-2\nblocks\tO\nand\tO\nheld\tT-3\noff\tT-3\nBailey\tB-PER\n's\tO\nlate\tO\nburst\tT-1\nin\tO\nthe\tO\nfinal\tO\n20\tO\nmetres\tO\nbefore\tO\nheading\tO\noff\tO\nfor\tO\na\tO\nlap\tO\nof\tO\ncelebration\tO\n.\tO\n\nThe\tO\nCanadian\tB-MISC\nwas\tO\nsecond\tT-0\nin\tO\n10.09\tO\nwith\tO\nLewis\tO\nthird\tO\nin\tO\n10.10\tO\n,\tO\nahead\tT-1\nof\tO\nAtlanta\tO\nbronze\tO\nmedallist\tO\nAto\tO\nBoldon\tO\nwho\tO\nclocked\tO\n10.12\tO\nin\tO\nfourth\tO\n.\tO\n\nThe\tO\nCanadian\tT-0\nwas\tO\nsecond\tO\nin\tO\n10.09\tO\nwith\tT-3\nLewis\tB-PER\nthird\tT-4\nin\tO\n10.10\tO\n,\tO\nahead\tO\nof\tO\nAtlanta\tO\nbronze\tO\nmedallist\tT-1\nAto\tT-2\nBoldon\tT-2\nwho\tO\nclocked\tO\n10.12\tO\nin\tO\nfourth\tO\n.\tO\n\nThe\tO\nCanadian\tO\nwas\tO\nsecond\tT-2\nin\tO\n10.09\tO\nwith\tO\nLewis\tO\nthird\tT-1\nin\tO\n10.10\tO\n,\tO\nahead\tO\nof\tO\nAtlanta\tB-LOC\nbronze\tT-3\nmedallist\tO\nAto\tO\nBoldon\tO\nwho\tO\nclocked\tT-0\n10.12\tO\nin\tO\nfourth\tO\n.\tO\n\nThe\tO\nCanadian\tO\nwas\tO\nsecond\tO\nin\tO\n10.09\tO\nwith\tO\nLewis\tO\nthird\tO\nin\tO\n10.10\tO\n,\tO\nahead\tO\nof\tO\nAtlanta\tO\nbronze\tO\nmedallist\tT-0\nAto\tB-PER\nBoldon\tI-PER\nwho\tO\nclocked\tO\n10.12\tO\nin\tO\nfourth\tO\n.\tO\n\nChristie\tB-PER\n,\tO\ncompeting\tT-2\nin\tO\nwhat\tO\nis\tO\nexpected\tO\nto\tO\nbe\tO\nhis\tT-0\nlast\tO\nmajor\tO\ninternational\tO\nmeeting\tT-1\n,\tO\nfinished\tO\nfifth\tO\nin\tO\n10.14\tO\n.\tO\n\nLewis\tB-PER\n,\tO\nmaking\tT-2\na\tO\nrare\tO\nappearance\tT-3\nin\tO\nEurope\tO\nin\tO\na\tO\nsprint\tT-1\nrace\tT-1\n,\tO\nleft\tO\nthe\tO\ntrack\tT-0\nwith\tO\na\tO\nslight\tO\nlimp\tO\n.\tO\n\nLewis\tO\n,\tO\nmaking\tO\na\tO\nrare\tO\nappearance\tO\nin\tO\nEurope\tB-LOC\nin\tO\na\tO\nsprint\tT-0\nrace\tO\n,\tO\nleft\tO\nthe\tO\ntrack\tO\nwith\tO\na\tO\nslight\tO\nlimp\tO\n.\tO\n\nAmerican\tB-MISC\nOlympic\tI-MISC\nhigh\tO\nhurdles\tT-1\nchampion\tT-3\nAllen\tO\nJohnson\tO\ndefied\tT-2\nthe\tO\nwet\tO\nconditions\tT-0\nto\tO\nproduce\tO\na\tO\nbrilliant\tO\n12.92\tO\nseconds\tO\nin\tO\nthe\tO\n110\tO\nmetres\tO\nrace\tO\n,\tO\njust\tO\n0.01\tO\noutside\tO\nthe\tO\nworld\tO\nrecord\tO\nheld\tO\nby\tO\nBritain\tO\n's\tO\nColin\tO\nJackson\tO\n.\tO\n\nAmerican\tO\nOlympic\tO\nhigh\tO\nhurdles\tO\nchampion\tT-0\nAllen\tB-PER\nJohnson\tI-PER\ndefied\tO\nthe\tO\nwet\tO\nconditions\tO\nto\tO\nproduce\tO\na\tO\nbrilliant\tO\n12.92\tO\nseconds\tO\nin\tO\nthe\tO\n110\tO\nmetres\tO\nrace\tO\n,\tO\njust\tO\n0.01\tO\noutside\tO\nthe\tO\nworld\tO\nrecord\tO\nheld\tO\nby\tO\nBritain\tO\n's\tO\nColin\tO\nJackson\tO\n.\tO\n\nAmerican\tO\nOlympic\tO\nhigh\tO\nhurdles\tO\nchampion\tT-1\nAllen\tT-1\nJohnson\tO\ndefied\tO\nthe\tO\nwet\tO\nconditions\tO\nto\tO\nproduce\tO\na\tO\nbrilliant\tO\n12.92\tO\nseconds\tO\nin\tO\nthe\tO\n110\tO\nmetres\tO\nrace\tO\n,\tO\njust\tO\n0.01\tO\noutside\tO\nthe\tO\nworld\tO\nrecord\tT-0\nheld\tT-2\nby\tO\nBritain\tB-LOC\n's\tO\nColin\tT-3\nJackson\tT-3\n.\tO\n\nAmerican\tO\nOlympic\tO\nhigh\tO\nhurdles\tO\nchampion\tO\nAllen\tO\nJohnson\tO\ndefied\tT-1\nthe\tO\nwet\tO\nconditions\tO\nto\tO\nproduce\tO\na\tO\nbrilliant\tO\n12.92\tO\nseconds\tO\nin\tO\nthe\tO\n110\tO\nmetres\tO\nrace\tO\n,\tO\njust\tO\n0.01\tO\noutside\tO\nthe\tO\nworld\tO\nrecord\tO\nheld\tO\nby\tO\nBritain\tT-0\n's\tT-0\nColin\tB-PER\nJackson\tI-PER\n.\tO\n\nJohnson\tB-PER\nran\tT-0\nthe\tO\nsame\tO\ntime\tO\nat\tO\nthe\tO\nU.S.\tO\nOlympic\tO\ntrials\tO\nin\tO\nAtlanta\tO\nin\tO\nJune\tO\nto\tO\nbecome\tT-1\nthe\tO\nsecond\tO\nequal\tO\nfastest\tO\nhurdler\tO\nof\tO\nall\tO\ntime\tO\nwith\tO\nAmerican\tO\nRoger\tO\nKingdom\tO\n.\tO\n\nJohnson\tT-0\nran\tO\nthe\tO\nsame\tO\ntime\tO\nat\tO\nthe\tO\nU.S.\tB-LOC\nOlympic\tO\ntrials\tO\nin\tO\nAtlanta\tO\nin\tO\nJune\tO\nto\tO\nbecome\tO\nthe\tO\nsecond\tO\nequal\tO\nfastest\tO\nhurdler\tO\nof\tO\nall\tO\ntime\tO\nwith\tO\nAmerican\tO\nRoger\tO\nKingdom\tO\n.\tO\n\nJohnson\tT-3\nran\tT-0\nthe\tO\nsame\tO\ntime\tO\nat\tO\nthe\tO\nU.S.\tO\nOlympic\tB-MISC\ntrials\tT-1\nin\tO\nAtlanta\tO\nin\tO\nJune\tO\nto\tO\nbecome\tO\nthe\tO\nsecond\tO\nequal\tO\nfastest\tO\nhurdler\tT-2\nof\tO\nall\tO\ntime\tO\nwith\tO\nAmerican\tO\nRoger\tO\nKingdom\tO\n.\tO\n\nJohnson\tO\nran\tO\nthe\tO\nsame\tO\ntime\tO\nat\tO\nthe\tO\nU.S.\tT-1\nOlympic\tT-1\ntrials\tO\nin\tO\nAtlanta\tB-LOC\nin\tO\nJune\tO\nto\tO\nbecome\tO\nthe\tO\nsecond\tO\nequal\tO\nfastest\tO\nhurdler\tO\nof\tO\nall\tO\ntime\tO\nwith\tO\nAmerican\tT-2\nRoger\tT-2\nKingdom\tT-2\n.\tO\n\nJohnson\tT-2\nran\tO\nthe\tO\nsame\tO\ntime\tO\nat\tO\nthe\tO\nU.S.\tO\nOlympic\tO\ntrials\tO\nin\tO\nAtlanta\tO\nin\tO\nJune\tO\nto\tO\nbecome\tO\nthe\tO\nsecond\tT-0\nequal\tT-0\nfastest\tT-0\nhurdler\tT-0\nof\tO\nall\tO\ntime\tO\nwith\tO\nAmerican\tB-MISC\nRoger\tT-1\nKingdom\tT-1\n.\tO\n\nJohnson\tT-1\nran\tO\nthe\tO\nsame\tO\ntime\tO\nat\tO\nthe\tO\nU.S.\tT-0\nOlympic\tT-0\ntrials\tT-0\nin\tO\nAtlanta\tO\nin\tO\nJune\tO\nto\tO\nbecome\tO\nthe\tO\nsecond\tO\nequal\tO\nfastest\tO\nhurdler\tT-2\nof\tO\nall\tO\ntime\tO\nwith\tO\nAmerican\tT-3\nRoger\tB-PER\nKingdom\tI-PER\n.\tO\n\nHe\tO\nseemed\tO\nto\tO\nrelish\tT-0\nthe\tO\nnew\tO\ntrack\tO\nat\tT-2\nthe\tT-2\nBrussels\tB-LOC\nmeeting\tO\n,\tO\ndominating\tT-1\nthe\tO\nrace\tO\nfrom\tO\nstart\tO\nto\tO\nfinish\tO\nwith\tO\na\tO\nslight\tO\nwind\tO\nat\tO\nhis\tO\nback\tO\n.\tO\n\nJackson\tB-PER\n,\tO\nthe\tO\nonly\tT-0\nman\tT-1\nto\tO\nhave\tO\nrun\tO\nfaster\tO\n,\tO\ncould\tO\nnot\tO\nlive\tO\nwith\tO\nhis\tO\nspeed\tO\n,\tO\ntaking\tO\nsecond\tO\nin\tO\n13.24\tO\nseconds\tO\n.\tO\n\nBut\tO\nSweden\tB-LOC\n's\tO\nOlympic\tO\nhigh\tO\nhurdles\tO\nchampion\tO\nLudmila\tT-0\nEngquist\tT-0\n,\tO\nwho\tO\ncrashed\tO\nout\tO\nof\tO\nlast\tO\nweek\tO\n's\tO\nmeeting\tT-2\nin\tO\nZurich\tT-3\nafter\tO\nhitting\tO\na\tO\nhurdle\tT-1\n,\tO\nalso\tO\nkept\tO\nher\tO\nfooting\tO\nperfectly\tO\nto\tO\nwin\tO\nin\tO\na\tO\nfast\tO\n12.60\tO\nseconds\tO\n.\tO\n\nBut\tO\nSweden\tT-2\n's\tT-2\nOlympic\tB-MISC\nhigh\tT-1\nhurdles\tT-1\nchampion\tT-1\nLudmila\tO\nEngquist\tO\n,\tO\nwho\tO\ncrashed\tO\nout\tO\nof\tO\nlast\tO\nweek\tO\n's\tO\nmeeting\tO\nin\tO\nZurich\tO\nafter\tO\nhitting\tO\na\tO\nhurdle\tO\n,\tO\nalso\tO\nkept\tO\nher\tO\nfooting\tO\nperfectly\tO\nto\tO\nwin\tO\nin\tO\na\tO\nfast\tO\n12.60\tO\nseconds\tO\n.\tO\n\nBut\tO\nSweden\tT-0\n's\tT-0\nOlympic\tT-0\nhigh\tT-0\nhurdles\tT-0\nchampion\tT-0\nLudmila\tB-PER\nEngquist\tI-PER\n,\tO\nwho\tO\ncrashed\tT-3\nout\tO\nof\tO\nlast\tO\nweek\tO\n's\tO\nmeeting\tT-2\nin\tO\nZurich\tO\nafter\tO\nhitting\tT-4\na\tO\nhurdle\tO\n,\tO\nalso\tO\nkept\tT-1\nher\tO\nfooting\tO\nperfectly\tO\nto\tO\nwin\tO\nin\tO\na\tO\nfast\tO\n12.60\tO\nseconds\tO\n.\tO\n\nBut\tO\nSweden\tT-1\n's\tO\nOlympic\tO\nhigh\tO\nhurdles\tO\nchampion\tO\nLudmila\tO\nEngquist\tO\n,\tO\nwho\tO\ncrashed\tO\nout\tO\nof\tO\nlast\tO\nweek\tO\n's\tO\nmeeting\tT-0\nin\tT-0\nZurich\tB-LOC\nafter\tO\nhitting\tO\na\tO\nhurdle\tO\n,\tO\nalso\tO\nkept\tO\nher\tO\nfooting\tO\nperfectly\tO\nto\tO\nwin\tO\nin\tO\na\tO\nfast\tO\n12.60\tO\nseconds\tO\n.\tO\n\nOlympic\tB-MISC\nsilver\tO\nmedallist\tO\nBrigita\tO\nBukovec\tO\nof\tO\nSlovenia\tO\ncould\tO\nfinish\tT-1\nonly\tO\nfifth\tO\nin\tO\nthe\tO\nrace\tT-0\nin\tO\n12.95\tO\n.\tO\n\nOlympic\tT-0\nsilver\tT-0\nmedallist\tT-1\nBrigita\tB-PER\nBukovec\tI-PER\nof\tO\nSlovenia\tO\ncould\tO\nfinish\tO\nonly\tO\nfifth\tO\nin\tO\nthe\tO\nrace\tO\nin\tO\n12.95\tO\n.\tO\n\nOlympic\tO\nsilver\tO\nmedallist\tT-0\nBrigita\tO\nBukovec\tO\nof\tT-1\nSlovenia\tB-LOC\ncould\tO\nfinish\tO\nonly\tO\nfifth\tO\nin\tO\nthe\tO\nrace\tO\nin\tO\n12.95\tO\n.\tO\n\nJamaican\tB-MISC\nCommonwealth\tO\nchampion\tO\nMichelle\tO\nFreeman\tO\ntook\tT-0\nsecond\tO\nin\tO\n12.77\tO\nahead\tT-1\nof\tO\nCuban\tO\nAliuska\tO\nLopez\tO\n.\tO\n\nJamaican\tT-0\nCommonwealth\tB-ORG\nchampion\tO\nMichelle\tO\nFreeman\tO\ntook\tT-1\nsecond\tO\nin\tO\n12.77\tO\nahead\tO\nof\tO\nCuban\tO\nAliuska\tO\nLopez\tO\n.\tO\n\nJamaican\tT-1\nCommonwealth\tT-1\nchampion\tO\nMichelle\tB-PER\nFreeman\tI-PER\ntook\tO\nsecond\tO\nin\tO\n12.77\tO\nahead\tT-0\nof\tO\nCuban\tO\nAliuska\tT-2\nLopez\tT-2\n.\tO\n\nJamaican\tO\nCommonwealth\tO\nchampion\tT-2\nMichelle\tO\nFreeman\tO\ntook\tT-0\nsecond\tO\nin\tO\n12.77\tO\nahead\tT-1\nof\tO\nCuban\tB-MISC\nAliuska\tO\nLopez\tO\n.\tO\n\nJamaican\tO\nCommonwealth\tO\nchampion\tO\nMichelle\tT-2\nFreeman\tT-2\ntook\tO\nsecond\tO\nin\tO\n12.77\tO\nahead\tT-1\nof\tO\nCuban\tT-0\nAliuska\tB-PER\nLopez\tI-PER\n.\tO\n\nThe\tO\nZurich\tB-LOC\nfall\tO\ncost\tO\nEngquist\tT-0\na\tO\nshot\tO\nat\tO\na\tO\njackpot\tO\nof\tO\n20\tO\none-kg\tO\ngold\tO\nbars\tO\nwhich\tO\ncan\tO\nbe\tO\nwon\tO\nby\tO\nathletes\tO\nwho\tO\nclinch\tO\ntheir\tO\nevents\tO\nat\tO\nall\tO\nof\tO\nthe\tO\nGolden\tO\nFour\tO\nseries\tO\nin\tO\nOslo\tO\n,\tO\nZurich\tO\n,\tO\nBrussels\tO\nand\tO\nBerlin\tO\n.\tO\n\nThe\tO\nZurich\tO\nfall\tO\ncost\tT-2\nEngquist\tB-PER\na\tO\nshot\tO\nat\tO\na\tO\njackpot\tO\nof\tO\n20\tO\none-kg\tO\ngold\tO\nbars\tO\nwhich\tO\ncan\tO\nbe\tO\nwon\tT-1\nby\tO\nathletes\tT-3\nwho\tO\nclinch\tT-0\ntheir\tO\nevents\tO\nat\tO\nall\tO\nof\tO\nthe\tO\nGolden\tO\nFour\tO\nseries\tO\nin\tO\nOslo\tO\n,\tO\nZurich\tO\n,\tO\nBrussels\tO\nand\tO\nBerlin\tO\n.\tO\n\nThe\tO\nZurich\tO\nfall\tO\ncost\tO\nEngquist\tO\na\tO\nshot\tO\nat\tO\na\tO\njackpot\tO\nof\tO\n20\tO\none-kg\tO\ngold\tT-3\nbars\tT-3\nwhich\tO\ncan\tO\nbe\tO\nwon\tO\nby\tO\nathletes\tO\nwho\tO\nclinch\tO\ntheir\tT-0\nevents\tT-0\nat\tO\nall\tO\nof\tO\nthe\tO\nGolden\tB-MISC\nFour\tI-MISC\nseries\tT-1\nin\tO\nOslo\tT-2\n,\tT-2\nZurich\tT-2\n,\tT-2\nBrussels\tT-2\nand\tT-2\nBerlin\tT-2\n.\tO\n\nThe\tO\nZurich\tO\nfall\tO\ncost\tO\nEngquist\tO\na\tO\nshot\tO\nat\tO\na\tO\njackpot\tT-0\nof\tO\n20\tO\none-kg\tO\ngold\tO\nbars\tO\nwhich\tO\ncan\tO\nbe\tO\nwon\tT-2\nby\tO\nathletes\tO\nwho\tO\nclinch\tO\ntheir\tO\nevents\tT-1\nat\tO\nall\tO\nof\tO\nthe\tO\nGolden\tO\nFour\tO\nseries\tT-3\nin\tT-3\nOslo\tB-LOC\n,\tO\nZurich\tO\n,\tO\nBrussels\tO\nand\tO\nBerlin\tO\n.\tO\n\nThe\tO\nZurich\tO\nfall\tO\ncost\tO\nEngquist\tO\na\tO\nshot\tO\nat\tO\na\tO\njackpot\tO\nof\tO\n20\tO\none-kg\tO\ngold\tO\nbars\tO\nwhich\tO\ncan\tO\nbe\tO\nwon\tO\nby\tO\nathletes\tO\nwho\tO\nclinch\tO\ntheir\tO\nevents\tO\nat\tO\nall\tO\nof\tO\nthe\tO\nGolden\tO\nFour\tO\nseries\tT-0\nin\tO\nOslo\tO\n,\tO\nZurich\tB-LOC\n,\tO\nBrussels\tO\nand\tO\nBerlin\tO\n.\tO\n\nThe\tO\nZurich\tO\nfall\tO\ncost\tT-2\nEngquist\tT-1\na\tO\nshot\tO\nat\tO\na\tO\njackpot\tO\nof\tO\n20\tO\none-kg\tO\ngold\tO\nbars\tO\nwhich\tO\ncan\tO\nbe\tO\nwon\tO\nby\tO\nathletes\tO\nwho\tO\nclinch\tO\ntheir\tO\nevents\tO\nat\tO\nall\tO\nof\tO\nthe\tO\nGolden\tO\nFour\tO\nseries\tO\nin\tO\nOslo\tO\n,\tO\nZurich\tO\n,\tO\nBrussels\tB-LOC\nand\tT-0\nBerlin\tO\n.\tO\n\nThe\tO\nZurich\tO\nfall\tT-1\ncost\tO\nEngquist\tO\na\tO\nshot\tO\nat\tO\na\tO\njackpot\tT-2\nof\tO\n20\tO\none-kg\tO\ngold\tO\nbars\tO\nwhich\tO\ncan\tO\nbe\tO\nwon\tT-3\nby\tO\nathletes\tO\nwho\tO\nclinch\tO\ntheir\tO\nevents\tO\nat\tO\nall\tO\nof\tO\nthe\tO\nGolden\tO\nFour\tO\nseries\tT-0\nin\tO\nOslo\tO\n,\tO\nZurich\tO\n,\tO\nBrussels\tO\nand\tO\nBerlin\tB-LOC\n.\tO\n\nSeven\tO\nathletes\tT-0\nwent\tO\ninto\tO\nFriday\tO\n's\tO\npenultimate\tT-2\nmeeting\tO\nof\tO\nthe\tO\nseries\tO\nwith\tO\na\tO\nchance\tO\nof\tO\nwinning\tT-3\nthe\tO\nprize\tO\nand\tO\nAmerican\tB-MISC\nmen\tO\n's\tO\n400\tO\nmetres\tO\nhurdles\tO\nchampion\tO\nDerrick\tT-1\nAdkins\tT-1\nkept\tO\nhis\tO\nhopes\tO\nalive\tO\nin\tO\nthe\tO\ncompetition\tO\nby\tO\nwinning\tO\nhis\tO\nevent\tO\nin\tO\n47.93\tO\n.\tO\n\nSeven\tO\nathletes\tO\nwent\tT-0\ninto\tO\nFriday\tO\n's\tO\npenultimate\tO\nmeeting\tO\nof\tO\nthe\tO\nseries\tO\nwith\tO\na\tO\nchance\tO\nof\tO\nwinning\tO\nthe\tO\nprize\tO\nand\tO\nAmerican\tO\nmen\tO\n's\tO\n400\tT-2\nmetres\tT-2\nhurdles\tT-2\nchampion\tT-2\nDerrick\tB-PER\nAdkins\tI-PER\nkept\tO\nhis\tO\nhopes\tT-1\nalive\tT-1\nin\tO\nthe\tO\ncompetition\tO\nby\tO\nwinning\tO\nhis\tO\nevent\tO\nin\tO\n47.93\tO\n.\tO\n\nAmerican\tB-MISC\nOlympic\tI-MISC\nchampion\tT-1\nGail\tO\nDevers\tO\nclocked\tT-2\na\tO\nswift\tO\n10.84\tO\nseconds\tO\non\tO\nher\tO\nway\tO\nto\tO\nvictory\tO\nin\tO\nthe\tO\nwomen\tT-0\n's\tT-0\n100\tT-0\nmetres\tT-0\n,\tO\nthe\tO\nsecond\tO\nfastest\tO\ntime\tO\nof\tO\nthe\tO\nseason\tO\nand\tO\n0.10\tO\nseconds\tO\nfaster\tO\nthan\tO\nher\tO\nwinning\tO\ntime\tO\nin\tO\nAtlanta\tO\n.\tO\n\nAmerican\tO\nOlympic\tO\nchampion\tT-1\nGail\tB-PER\nDevers\tI-PER\nclocked\tT-2\na\tO\nswift\tO\n10.84\tO\nseconds\tO\non\tO\nher\tO\nway\tO\nto\tO\nvictory\tO\nin\tO\nthe\tO\nwomen\tO\n's\tO\n100\tO\nmetres\tO\n,\tO\nthe\tO\nsecond\tO\nfastest\tO\ntime\tO\nof\tO\nthe\tO\nseason\tO\nand\tO\n0.10\tO\nseconds\tO\nfaster\tO\nthan\tO\nher\tO\nwinning\tO\ntime\tO\nin\tO\nAtlanta\tO\n.\tT-0\n\nAmerican\tT-1\nOlympic\tT-1\nchampion\tT-1\nGail\tO\nDevers\tO\nclocked\tT-0\na\tO\nswift\tO\n10.84\tO\nseconds\tO\non\tO\nher\tO\nway\tO\nto\tO\nvictory\tO\nin\tO\nthe\tO\nwomen\tO\n's\tO\n100\tO\nmetres\tO\n,\tO\nthe\tO\nsecond\tO\nfastest\tO\ntime\tO\nof\tO\nthe\tO\nseason\tO\nand\tO\n0.10\tO\nseconds\tO\nfaster\tO\nthan\tO\nher\tO\nwinning\tO\ntime\tO\nin\tO\nAtlanta\tB-LOC\n.\tO\n\nJamaican\tB-MISC\nveteran\tO\nMerlene\tO\nOttey\tO\n,\tO\nwho\tO\nbeat\tT-0\nDevers\tO\nin\tO\nZurich\tO\nafter\tO\njust\tO\nmissing\tO\nout\tO\non\tO\nthe\tO\ngold\tO\nmedal\tO\nin\tO\nAtlanta\tO\nafter\tO\na\tO\nphoto\tO\nfinish\tO\n,\tO\nhad\tO\nto\tO\nsettle\tO\nfor\tO\nthird\tO\nplace\tO\nin\tO\n11.04\tO\n.\tO\n\nJamaican\tT-2\nveteran\tT-2\nMerlene\tB-PER\nOttey\tI-PER\n,\tO\nwho\tO\nbeat\tO\nDevers\tO\nin\tO\nZurich\tT-3\nafter\tO\njust\tO\nmissing\tO\nout\tO\non\tO\nthe\tO\ngold\tO\nmedal\tO\nin\tO\nAtlanta\tO\nafter\tO\na\tO\nphoto\tO\nfinish\tO\n,\tO\nhad\tO\nto\tO\nsettle\tT-0\nfor\tO\nthird\tO\nplace\tO\nin\tO\n11.04\tO\n.\tO\n\nJamaican\tO\nveteran\tO\nMerlene\tO\nOttey\tO\n,\tO\nwho\tO\nbeat\tO\nDevers\tB-PER\nin\tO\nZurich\tO\nafter\tO\njust\tO\nmissing\tT-0\nout\tT-0\non\tO\nthe\tO\ngold\tO\nmedal\tO\nin\tO\nAtlanta\tO\nafter\tO\na\tO\nphoto\tO\nfinish\tO\n,\tO\nhad\tO\nto\tO\nsettle\tO\nfor\tO\nthird\tO\nplace\tO\nin\tO\n11.04\tO\n.\tO\n\nJamaican\tT-2\nveteran\tT-2\nMerlene\tT-2\nOttey\tT-2\n,\tO\nwho\tO\nbeat\tT-0\nDevers\tO\nin\tO\nZurich\tB-LOC\nafter\tO\njust\tO\nmissing\tO\nout\tO\non\tO\nthe\tO\ngold\tO\nmedal\tO\nin\tO\nAtlanta\tO\nafter\tO\na\tO\nphoto\tO\nfinish\tO\n,\tO\nhad\tO\nto\tO\nsettle\tT-1\nfor\tO\nthird\tO\nplace\tT-3\nin\tO\n11.04\tO\n.\tO\n\nJamaican\tO\nveteran\tO\nMerlene\tO\nOttey\tO\n,\tO\nwho\tO\nbeat\tT-1\nDevers\tO\nin\tO\nZurich\tO\nafter\tO\njust\tO\nmissing\tO\nout\tO\non\tO\nthe\tO\ngold\tO\nmedal\tO\nin\tO\nAtlanta\tB-LOC\nafter\tT-0\na\tT-0\nphoto\tT-0\nfinish\tT-0\n,\tO\nhad\tO\nto\tO\nsettle\tT-2\nfor\tO\nthird\tO\nplace\tO\nin\tO\n11.04\tO\n.\tO\n\nAmerican\tB-MISC\nworld\tT-1\nchampion\tT-1\nGwen\tO\nTorrence\tO\n,\tO\nthe\tO\nbronze\tT-0\nmedallist\tT-0\nin\tT-0\nAtlanta\tT-0\n,\tO\nwas\tO\nsecond\tO\nin\tO\n11.00\tO\n.\tO\n\nAmerican\tO\nworld\tO\nchampion\tT-1\nGwen\tB-PER\nTorrence\tI-PER\n,\tO\nthe\tO\nbronze\tT-0\nmedallist\tO\nin\tO\nAtlanta\tO\n,\tO\nwas\tO\nsecond\tO\nin\tO\n11.00\tO\n.\tO\n\nAmerican\tO\nworld\tO\nchampion\tT-0\nGwen\tT-1\nTorrence\tT-1\n,\tO\nthe\tO\nbronze\tO\nmedallist\tO\nin\tO\nAtlanta\tB-LOC\n,\tO\nwas\tO\nsecond\tO\nin\tO\n11.00\tO\n.\tO\n\nIt\tO\nwas\tO\na\tO\ncostly\tO\ndefeat\tO\nfor\tO\nOttey\tB-PER\nsince\tO\nit\tO\nthrew\tO\nher\tO\nout\tO\nof\tO\nthe\tO\nrace\tO\nfor\tO\nthe\tO\nGolden\tT-0\nFour\tO\njackpot\tO\n.\tO\n\nIt\tO\nwas\tO\na\tO\ncostly\tO\ndefeat\tO\nfor\tO\nOttey\tO\nsince\tO\nit\tO\nthrew\tO\nher\tO\nout\tO\nof\tO\nthe\tO\nrace\tO\nfor\tT-0\nthe\tT-0\nGolden\tB-MISC\nFour\tI-MISC\njackpot\tO\n.\tO\n\nATHLETICS\tT-1\n-\tO\nBRUSSELS\tB-MISC\nGRAND\tI-MISC\nPRIX\tI-MISC\nRESULTS\tT-2\n.\tO\n\nLeading\tT-0\nresults\tT-1\nin\tO\nthe\tO\nBrussels\tB-MISC\n\nGrand\tB-MISC\nPrix\tI-MISC\nathletics\tO\nmeeting\tT-0\non\tO\nFriday\tT-1\n:\tO\n\n1.\tO\nIlke\tB-PER\nWyludda\tI-PER\n(\tO\nGermany\tT-0\n)\tO\n66.60\tT-1\nmetres\tT-1\n\n1.\tO\nIlke\tO\nWyludda\tO\n(\tO\nGermany\tB-LOC\n)\tO\n66.60\tT-0\nmetres\tT-0\n\n2.\tO\nEllina\tB-PER\nZvereva\tI-PER\n(\tO\nBelarus\tT-0\n)\tO\n65.66\tO\n\n3.\tO\nFranka\tB-PER\nDietzsch\tI-PER\n(\tO\nGermany\tT-0\n)\tO\n61.74\tO\n\n3.\tO\nFranka\tT-0\nDietzsch\tT-0\n(\tO\nGermany\tB-LOC\n)\tO\n61.74\tO\n\n4.\tO\nNatalya\tB-PER\nSadova\tI-PER\n(\tO\nRussia\tO\n)\tO\n61.64\tT-0\n\n4.\tO\nNatalya\tT-0\nSadova\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\n61.64\tO\n\n5.\tO\nMette\tB-PER\nBergmann\tI-PER\n(\tO\nNorway\tT-0\n)\tO\n61.44\tO\n\n5.\tO\nMette\tO\nBergmann\tO\n(\tO\nNorway\tB-LOC\n)\tO\n61.44\tT-0\n\n6.\tO\nNicoleta\tB-PER\nGrasu\tI-PER\n(\tO\nRomania\tT-0\n)\tO\n61.36\tO\n\n6.\tO\nNicoleta\tT-0\nGrasu\tT-0\n(\tO\nRomania\tB-LOC\n)\tO\n61.36\tO\n\n7.\tO\nOlga\tB-PER\nChernyavskaya\tI-PER\n(\tO\nRussia\tT-0\n)\tO\n60.46\tT-1\n\n7.\tO\nOlga\tT-0\nChernyavskaya\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\n60.46\tO\n\n8.\tO\nIrina\tT-0\nYatchenko\tT-0\n(\tO\nBelarus\tB-LOC\n)\tO\n58.92\tO\n\n1.\tO\nLudmila\tB-PER\nEngquist\tI-PER\n(\tO\nSweden\tT-0\n)\tO\n12.60\tO\nseconds\tO\n\n1.\tO\nLudmila\tO\nEngquist\tO\n(\tO\nSweden\tB-LOC\n)\tO\n12.60\tT-0\nseconds\tT-0\n\n2.\tO\nMichelle\tB-PER\nFreeman\tI-PER\n(\tO\nJamaica\tT-0\n)\tO\n12.77\tO\n\n3.\tO\nAliuska\tB-PER\nLopez\tI-PER\n(\tO\nCuba\tT-0\n)\tO\n12.85\tO\n\n3.\tO\nAliuska\tO\nLopez\tO\n(\tO\nCuba\tB-LOC\n)\tO\n12.85\tT-0\n\n4.\tO\nDionne\tB-PER\nRose\tI-PER\n(\tO\nJamaica\tT-0\n)\tO\n12.88\tO\n\n4.\tO\nDionne\tT-0\nRose\tT-0\n(\tO\nJamaica\tB-LOC\n)\tO\n12.88\tT-1\n\n5.\tO\nBrigita\tB-PER\nBukovec\tI-PER\n(\tO\nSlovakia\tO\n)\tO\n12.95\tT-0\n\n5.\tO\nBrigita\tT-0\nBukovec\tT-0\n(\tO\nSlovakia\tB-LOC\n)\tO\n12.95\tO\n\n6.\tO\nYulia\tB-PER\nGraudin\tI-PER\n(\tO\nRussia\tT-0\n)\tO\n12.96\tT-1\n\n6.\tO\nYulia\tT-0\nGraudin\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\n12.96\tO\n\n7.\tO\nJulie\tB-PER\nBaumann\tI-PER\n(\tO\nSwitzerland\tT-0\n)\tO\n13.36\tO\n\n8.\tO\nPatricia\tB-PER\nGirard-Leno\tI-PER\n(\tO\nFrance\tT-0\n)\tO\n13.36\tO\n\n9.\tO\nDawn\tB-PER\nBowles\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n13.53\tO\n\n9.\tO\nDawn\tT-0\nBowles\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n13.53\tO\n\n1.\tO\nAllen\tB-PER\nJohnson\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n12.92\tT-1\nseconds\tO\n\n1.\tO\nAllen\tT-0\nJohnson\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n12.92\tO\nseconds\tO\n\n2.\tO\nColin\tB-PER\nJackson\tI-PER\n(\tO\nBritain\tT-0\n)\tO\n13.24\tT-1\n\n2.\tO\nColin\tT-0\nJackson\tT-1\n(\tO\nBritain\tB-LOC\n)\tO\n13.24\tO\n\n3.\tO\nEmilio\tB-PER\nValle\tI-PER\n(\tO\nCuba\tO\n)\tO\n13.33\tT-0\n\n4.\tO\nSven\tB-PER\nPieters\tI-PER\n(\tO\nBelgium\tT-1\n)\tO\n13.37\tT-0\n\n4.\tO\nSven\tT-0\nPieters\tT-0\n(\tO\nBelgium\tB-LOC\n)\tO\n13.37\tO\n\n6.\tO\nFrank\tB-PER\nAsselman\tI-PER\n(\tO\nBelgium\tT-0\n)\tO\n13.64\tO\n\n7.\tO\nHubert\tB-PER\nGrossard\tI-PER\n(\tO\nBelgium\tT-0\n)\tO\n13.65\tT-1\n\n7.\tO\nHubert\tT-0\nGrossard\tT-0\n(\tO\nBelgium\tB-LOC\n)\tO\n13.65\tO\n\n8.\tO\nJonathan\tB-PER\nN'Senga\tI-PER\n(\tO\nBelgium\tO\n)\tO\n13.66\tT-0\n\n9.\tO\nJohan\tB-PER\nLisabeth\tI-PER\n(\tO\nBelgium\tT-0\n)\tO\n13.75\tO\n\n9.\tO\nJohan\tO\nLisabeth\tT-0\n(\tO\nBelgium\tB-LOC\n)\tO\n13.75\tT-0\n\n1.\tO\nRoberta\tB-PER\nBrunet\tI-PER\n(\tO\nItaly\tO\n)\tO\n14\tO\nminutes\tO\n48.96\tO\nseconds\tT-0\n\n1.\tO\nRoberta\tT-0\nBrunet\tT-0\n(\tO\nItaly\tB-LOC\n)\tO\n14\tO\nminutes\tO\n48.96\tO\nseconds\tO\n\n2.\tO\nFernanda\tB-PER\nRibeiro\tI-PER\n(\tO\nPortugal\tO\n)\tO\n14:49.81\tT-0\n\n3.\tO\nSally\tB-PER\nBarsosio\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n14:58.29\tO\n\n3.\tO\nSally\tO\nBarsosio\tO\n(\tO\nKenya\tB-LOC\n)\tO\n14:58.29\tT-0\n\n5.\tO\nJulia\tB-PER\nVaquero\tI-PER\n(\tO\nSpain\tT-0\n)\tO\n15:04.94\tT-1\n\n6.\tO\nCatherine\tB-PER\nMcKiernan\tI-PER\n(\tO\nIreland\tT-0\n)\tO\n15:07.57\tO\n\n7.\tO\nAnnette\tB-PER\nPeters\tI-PER\n(\tO\nU.S.\tO\n)\tO\n15:07.85\tT-0\n\n7.\tO\nAnnette\tT-0\nPeters\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n15:07.85\tO\n\n8.\tO\nPauline\tB-PER\nKonga\tI-PER\n(\tO\nKenya\tT-1\n)\tO\n15:11.40\tT-0\n\n8.\tO\nPauline\tT-0\nKonga\tO\n(\tO\nKenya\tB-LOC\n)\tO\n15:11.40\tT-1\n\n1.\tO\nDennis\tO\nMitchell\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n10.03\tT-0\nseconds\tO\n\n2.\tO\nDonovan\tT-0\nBailey\tT-0\n(\tO\nCanada\tB-LOC\n)\tO\n10.09\tO\n\n3.\tO\nCarl\tT-0\nLewis\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n10.10\tO\n\n4.\tO\nAto\tB-PER\nBoldon\tI-PER\n(\tO\nTrinidad\tT-0\n)\tO\n10.12\tO\n\n4.\tO\nAto\tT-1\nBoldon\tT-1\n(\tO\nTrinidad\tB-LOC\n)\tO\n10.12\tT-0\n\n5.\tO\nLinford\tT-0\nChristie\tT-0\n(\tO\nBritain\tB-LOC\n)\tO\n10.14\tO\n\n7.\tO\nJon\tB-PER\nDrummond\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n10.16\tO\n\n7.\tO\nJon\tT-0\nDrummond\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n10.16\tO\n\n8.\tO\nBruny\tB-PER\nSurin\tI-PER\n(\tO\nCanada\tT-0\n)\tO\n10.30\tO\n\n8.\tO\nBruny\tT-0\nSurin\tT-0\n(\tO\nCanada\tB-LOC\n)\tO\n10.30\tO\n\n1.\tO\nDerrick\tB-PER\nAdkins\tI-PER\n(\tO\nU.S.\tO\n)\tO\n47.93\tO\nseconds\tT-0\n\n2.\tO\nSamuel\tB-PER\nMatete\tI-PER\n(\tO\nZambia\tT-0\n)\tO\n47.99\tO\n\n2.\tO\nSamuel\tO\nMatete\tO\n(\tO\nZambia\tB-LOC\n)\tO\n47.99\tT-0\n\n3.\tO\nRohan\tB-PER\nRobinson\tI-PER\n(\tT-0\nAustralia\tT-0\n)\tT-0\n48.86\tO\n\n3.\tO\nRohan\tO\nRobinson\tO\n(\tO\nAustralia\tB-LOC\n)\tO\n48.86\tT-0\n\n4.\tO\nTorrance\tB-PER\nZellner\tI-PER\n(\tO\nU.S.\tO\n)\tO\n49.06\tT-0\n\n4.\tO\nTorrance\tT-0\nZellner\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n49.06\tT-1\n\n5.\tO\nJean-Paul\tB-PER\nBruwier\tI-PER\n(\tO\nBelgium\tT-0\n)\tO\n49.24\tO\n\n5.\tO\nJean-Paul\tT-0\nBruwier\tT-0\n(\tO\nBelgium\tB-LOC\n)\tO\n49.24\tO\n\n6.\tO\nDusan\tT-0\nKovacs\tT-0\n(\tO\nHungary\tB-LOC\n)\tO\n49.31\tO\n\n7.\tO\nCalvin\tB-PER\nDavis\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n49.49\tO\n\n7.\tO\nCalvin\tT-0\nDavis\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n49.49\tO\n\n8.\tO\nLaurent\tB-PER\nOttoz\tI-PER\n(\tO\nItaly\tT-0\n)\tO\n49.61\tO\n\n8.\tO\nLaurent\tT-0\nOttoz\tT-0\n(\tO\nItaly\tB-LOC\n)\tO\n49.61\tO\n\n9.\tO\nMarc\tB-PER\nDollendorf\tI-PER\n(\tO\nBelgium\tT-1\n)\tO\n50.36\tO\n\n9.\tO\nMarc\tT-1\nDollendorf\tT-1\n(\tO\nBelgium\tB-LOC\n)\tO\n50.36\tT-0\n\n1.\tO\nGail\tB-PER\nDevers\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n10.84\tO\nseconds\tO\n\n1.\tO\nGail\tT-0\nDevers\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n10.84\tO\nseconds\tO\n\n2.\tO\nGwen\tB-PER\nTorrence\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n11.00\tO\n\n2.\tO\nGwen\tT-0\nTorrence\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n11.00\tO\n\n3.\tO\nMerlene\tB-PER\nOttey\tI-PER\n(\tO\nJamaica\tT-0\n)\tO\n11.04\tO\n\n3.\tO\nMerlene\tT-1\nOttey\tT-1\n(\tO\nJamaica\tB-LOC\n)\tO\n11.04\tT-0\n\n4.\tO\nMary\tB-PER\nOnyali\tI-PER\n(\tO\nNigeria\tT-0\n)\tO\n11.09\tO\n\n4.\tO\nMary\tT-1\nOnyali\tT-1\n(\tO\nNigeria\tB-LOC\n)\tO\n11.09\tO\n\n5.\tO\nChryste\tT-0\nGaines\tO\n(\tO\nU.S.\tB-LOC\n)\tO\n11.18\tO\n\n6.\tO\nZhanna\tB-PER\nPintusevich\tI-PER\n(\tO\nUkraine\tT-0\n)\tO\n11.27\tO\n\n6.\tO\nZhanna\tT-0\nPintusevich\tT-0\n(\tO\nUkraine\tB-LOC\n)\tO\n11.27\tO\n\n7.\tO\nIrina\tB-PER\nPrivalova\tI-PER\n(\tO\nRussia\tT-0\n)\tO\n11.28\tO\n\n7.\tO\nIrina\tO\nPrivalova\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\n11.28\tO\n\n8.\tO\nNatalia\tB-PER\nVoronova\tI-PER\n(\tO\nRussia\tT-1\n)\tO\n11.28\tT-0\n\n9.\tO\nJuliet\tB-PER\nCuthbert\tI-PER\n(\tO\nJamaica\tT-0\n)\tO\n11.31\tO\n\n9.\tO\nJuliet\tT-0\nCuthbert\tT-0\n(\tO\nJamaica\tB-LOC\n)\tO\n11.31\tO\n\n1.\tO\nRegina\tB-PER\nJacobs\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n4\tO\nminutes\tO\n01.77\tO\nseconds\tO\n\n1.\tO\nRegina\tT-0\nJacobs\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n4\tO\nminutes\tO\n01.77\tO\nseconds\tO\n\n2.\tO\nPatricia\tB-PER\nDjate\tI-PER\n(\tO\nFrance\tO\n)\tO\n4:02.26\tT-0\n\n3.\tO\nCarla\tB-PER\nSacramento\tI-PER\n(\tO\nPortugal\tT-0\n)\tO\n4:02.67\tT-1\n\n3.\tO\nCarla\tT-1\nSacramento\tT-1\n(\tO\nPortugal\tB-LOC\n)\tO\n4:02.67\tT-0\n\n5.\tO\nMargret\tB-PER\nCrowley\tI-PER\n(\tO\nAustralia\tT-0\n)\tO\n4:05.00\tO\n\n6.\tO\nLeah\tO\nPells\tO\n(\tO\nCanada\tB-LOC\n)\tO\n4:05.64\tT-0\n\n7.\tO\nSarah\tB-PER\nThorsett\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n4:06.80\tT-1\n\n7.\tO\nSarah\tT-0\nThorsett\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n4:06.80\tT-1\n\n8.\tO\nSinead\tB-PER\nDelahunty\tI-PER\n(\tO\nIreland\tT-0\n)\tO\n4:07.27\tT-1\n\n1.\tO\nJoseph\tB-PER\nKeter\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n8\tO\nminutes\tO\n10.02\tO\nseconds\tO\n\n2.\tO\nPatrick\tT-0\nSang\tT-0\n(\tO\nKenya\tB-LOC\n)\tO\n8:12.04\tO\n\n3.\tO\nMoses\tT-0\nKiptanui\tT-0\n(\tO\nKenya\tB-LOC\n)\tO\n8:12.65\tO\n\n4.\tO\nGideon\tB-PER\nChirchir\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n8:15.69\tO\n\n4.\tO\nGideon\tT-0\nChirchir\tT-0\n(\tO\nKenya\tB-LOC\n)\tO\n8:15.69\tO\n\n5.\tO\nRichard\tB-PER\nKosgei\tI-PER\n(\tO\nKenya\tO\n)\tO\n8:16.80\tT-0\n\n5.\tO\nRichard\tT-0\nKosgei\tO\n(\tO\nKenya\tB-LOC\n)\tO\n8:16.80\tO\n\n6.\tO\nLarbi\tT-0\nEl\tT-0\nKhattabi\tT-0\n(\tO\nMorocco\tB-LOC\n)\tO\n8:17.29\tO\n\n7.\tO\nEliud\tB-PER\nBarngetuny\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n8:17.66\tT-1\n\n7.\tO\nEliud\tT-0\nBarngetuny\tT-0\n(\tO\nKenya\tB-LOC\n)\tO\n8:17.66\tO\n\n8.\tO\nBernard\tB-PER\nBarmasai\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n8:17.94\tO\n\n1.\tO\nMichael\tB-PER\nJohnson\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n44.29\tT-1\nseconds\tT-1\n\n2.\tO\nDerek\tB-PER\nMills\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n44.78\tO\n\n2.\tO\nDerek\tT-0\nMills\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n44.78\tO\n\n3.\tO\nAnthuan\tB-PER\nMaybank\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n44.92\tO\n\n3.\tO\nAnthuan\tT-0\nMaybank\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n44.92\tO\n\n4.\tO\nDavis\tB-PER\nKamoga\tI-PER\n(\tO\nUganda\tT-0\n)\tO\n44.96\tT-1\n\n4.\tO\nDavis\tO\nKamoga\tO\n(\tO\nUganda\tB-LOC\n)\tO\n44.96\tT-0\n\n5.\tO\nJamie\tT-0\nBaulch\tT-0\n(\tO\nBritain\tB-LOC\n)\tO\n45.08\tO\n\n6.\tO\nSunday\tB-PER\nBada\tI-PER\n(\tO\nNigeria\tT-0\n)\tO\n45.21\tO\n\n6.\tO\nSunday\tT-0\nBada\tT-0\n(\tO\nNigeria\tB-LOC\n)\tO\n45.21\tO\n\n7.\tO\nSamson\tB-PER\nKitur\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n45.34\tO\n\n8.\tO\nMark\tB-PER\nRichardson\tI-PER\n(\tO\nBritain\tT-0\n)\tT-0\n45.67\tT-0\n\n8.\tO\nMark\tT-0\nRichardson\tT-0\n(\tO\nBritain\tB-LOC\n)\tO\n45.67\tO\n\n9.\tO\nJason\tB-PER\nRouser\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n46.11\tT-0\n\n9.\tO\nJason\tT-0\nRouser\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n46.11\tO\n\n1.\tO\nFrankie\tB-PER\nFredericks\tI-PER\n(\tO\nNamibia\tT-1\n)\tO\n19.92\tO\nseconds\tO\n\n1.\tO\nFrankie\tT-0\nFredericks\tT-0\n(\tO\nNamibia\tB-LOC\n)\tO\n19.92\tO\nseconds\tO\n\n2.\tO\nAto\tB-PER\nBoldon\tI-PER\n(\tO\nTrinidad\tT-0\n)\tO\n19.99\tO\n\n2.\tO\nAto\tT-0\nBoldon\tT-0\n(\tO\nTrinidad\tB-LOC\n)\tO\n19.99\tO\n\n3.\tO\nJeff\tB-PER\nWilliams\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n20.21\tO\n\n3.\tO\nJeff\tT-1\nWilliams\tT-1\n(\tO\nU.S.\tB-LOC\n)\tO\n20.21\tT-0\n\n4.\tO\nJon\tT-0\nDrummond\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n20.42\tO\n\n5.\tO\nPatrick\tT-0\nStevens\tT-0\n(\tO\nBelgium\tB-LOC\n)\tO\n20.42\tO\n\n6.\tO\nMichael\tB-PER\nMarsh\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n20.43\tO\n\n6.\tO\nMichael\tT-0\nMarsh\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n20.43\tO\n\n8.\tO\nEric\tB-PER\nWymeersch\tI-PER\n(\tO\nBelgium\tT-1\n)\tO\n20.84\tO\n\n8.\tO\nEric\tT-0\nWymeersch\tT-2\n(\tO\nBelgium\tB-LOC\n)\tO\n20.84\tT-1\n\n1.\tO\nSvetlana\tB-PER\nMasterkova\tI-PER\n(\tO\nRussia\tT-0\n)\tO\n2\tO\nminutes\tO\n28.98\tO\nseconds\tO\n\n1.\tO\nSvetlana\tT-0\nMasterkova\tO\n(\tO\nRussia\tB-LOC\n)\tO\n2\tO\nminutes\tT-1\n28.98\tO\nseconds\tO\n\n2.\tO\nMaria\tB-PER\nMutola\tI-PER\n(\tO\nMozambique\tT-1\n)\tO\n2:29.66\tT-0\n\n3.\tO\nMalgorzata\tB-PER\nRydz\tI-PER\n(\tO\nPoland\tT-0\n)\tO\n2:39.00\tO\n\n3.\tO\nMalgorzata\tT-0\nRydz\tO\n(\tO\nPoland\tB-LOC\n)\tO\n2:39.00\tO\n\n4.\tO\nAnja\tO\nSmolders\tO\n(\tO\nBelgium\tB-LOC\n)\tO\n2:43.06\tT-0\n\n5.\tO\nVeerle\tB-PER\nDe\tI-PER\nJaeghere\tI-PER\n(\tO\nBelgium\tT-0\n)\tO\n2:43.18\tO\n\n5.\tO\nVeerle\tT-0\nDe\tT-0\nJaeghere\tT-0\n(\tO\nBelgium\tB-LOC\n)\tO\n2:43.18\tO\n\n6.\tO\nEleonora\tB-PER\nBerlanda\tI-PER\n(\tO\nItaly\tT-0\n)\tO\n2:43.44\tO\n\n7.\tO\nAnneke\tB-PER\nMatthijs\tI-PER\n(\tO\nBelgium\tT-0\n)\tO\n2:43.82\tO\n\n7.\tO\nAnneke\tT-1\nMatthijs\tT-2\n(\tO\nBelgium\tB-LOC\n)\tO\n2:43.82\tO\n\n8.\tO\nJacqueline\tT-0\nMartin\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n2:44.22\tO\n\n1.\tO\nMary\tB-PER\nOnyali\tI-PER\n(\tO\nNigeria\tT-0\n)\tO\n22.42\tO\nseconds\tO\n\n1.\tO\nMary\tT-0\nOnyali\tT-0\n(\tO\nNigeria\tB-LOC\n)\tO\n22.42\tO\nseconds\tO\n\n2.\tO\nInger\tB-PER\nMiller\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n22.66\tO\n\n2.\tO\nInger\tT-0\nMiller\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n22.66\tT-1\n\n3.\tO\nIrina\tB-PER\nPrivalova\tI-PER\n(\tO\nRussia\tT-0\n)\tO\n22.68\tO\n\n3.\tO\nIrina\tT-0\nPrivalova\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\n22.68\tO\n\n4.\tO\nNatalia\tB-PER\nVoronova\tI-PER\n(\tO\nRussia\tT-1\n)\tO\n22.73\tT-0\n\n4.\tO\nNatalia\tT-0\nVoronova\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\n22.73\tO\n\n5.\tO\nMarina\tB-PER\nTrandenkova\tI-PER\n(\tO\nRussia\tT-2\n)\tO\n22.84\tT-1\n\n6.\tO\nChandra\tB-PER\nSturrup\tI-PER\n(\tO\nBahamas\tT-0\n)\tO\n22.85\tT-1\n\n6.\tO\nChandra\tT-0\nSturrup\tT-0\n(\tO\nBahamas\tB-LOC\n)\tO\n22.85\tT-1\n\n7.\tO\nZundra\tB-PER\nFeagin\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n23.18\tT-1\n\n7.\tO\nZundra\tT-1\nFeagin\tT-1\n(\tT-0\nU.S.\tB-LOC\n)\tO\n23.18\tO\n\n8.\tO\nGalina\tB-PER\nMalchugina\tI-PER\n(\tO\nRussia\tT-0\n)\tO\n23.25\tT-1\n\n8.\tO\nGalina\tT-0\nMalchugina\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\n23.25\tO\n\n1.\tO\nCathy\tB-PER\nFreeman\tI-PER\n(\tO\nAustralia\tT-0\n)\tO\n49.48\tT-1\nseconds\tO\n\n1.\tO\nCathy\tT-0\nFreeman\tT-0\n(\tO\nAustralia\tB-LOC\n)\tO\n49.48\tO\nseconds\tO\n\n2.\tO\nMarie-Jose\tB-PER\nPerec\tI-PER\n(\tO\nFrance\tT-0\n)\tO\n49.72\tO\n\n2.\tO\nMarie-Jose\tT-0\nPerec\tT-0\n(\tO\nFrance\tB-LOC\n)\tO\n49.72\tO\n\n3.\tO\nFalilat\tB-PER\nOgunkoya\tI-PER\n(\tO\nNigeria\tO\n)\tO\n49.97\tT-0\n\n3.\tO\nFalilat\tT-1\nOgunkoya\tT-2\n(\tO\nNigeria\tB-LOC\n)\tO\n49.97\tT-0\n\n4.\tO\nPauline\tB-PER\nDavis\tI-PER\n(\tO\nBahamas\tT-0\n)\tO\n50.14\tO\n\n5.\tO\nFatima\tB-PER\nYussuf\tI-PER\n(\tO\nNigeria\tT-0\n)\tO\n50.14\tO\n\n5.\tO\nFatima\tT-0\nYussuf\tT-0\n(\tO\nNigeria\tB-LOC\n)\tO\n50.14\tT-1\n\n6.\tO\nMaicel\tB-PER\nMalone\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n50.51\tT-1\n\n6.\tO\nMaicel\tO\nMalone\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n50.51\tT-1\n\n7.\tO\nHana\tB-PER\nBenesova\tI-PER\n(\tO\nCzech\tT-0\nRepublic\tT-0\n)\tO\n51.71\tO\n\n7.\tO\nHana\tT-0\nBenesova\tT-1\n(\tO\nCzech\tB-LOC\nRepublic\tI-LOC\n)\tO\n51.71\tO\n\n8.\tO\nAnn\tB-PER\nMercken\tI-PER\n(\tO\nBelgium\tT-0\n)\tO\n53.55\tO\n\n1.\tO\nDaniel\tB-PER\nKomen\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n7\tO\nminutes\tO\n25.87\tO\nseconds\tO\n\n2.\tO\nKhalid\tT-1\nBoulami\tT-1\n(\tO\nMorocco\tB-LOC\n)\tO\n7:31.65\tO\n\n3.\tO\nBob\tB-PER\nKennedy\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n7:31.69\tT-1\n\n3.\tO\nBob\tT-0\nKennedy\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n7:31.69\tO\n\n4.\tO\nEl\tB-PER\nHassane\tI-PER\nLahssini\tI-PER\n(\tO\nMorocco\tT-0\n)\tO\n7:32.44\tO\n\n4.\tO\nEl\tT-0\nHassane\tT-0\nLahssini\tT-0\n(\tO\nMorocco\tB-LOC\n)\tO\n7:32.44\tO\n\n5.\tO\nThomas\tB-PER\nNyariki\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n7:35.56\tO\n\n5.\tO\nThomas\tO\nNyariki\tO\n(\tO\nKenya\tB-LOC\n)\tO\n7:35.56\tT-0\n\n6.\tO\nNoureddine\tO\nMorceli\tT-0\n(\tO\nAlgeria\tB-LOC\n)\tO\n7:36.81\tT-1\n\n7.\tO\nFita\tB-PER\nBayesa\tI-PER\n(\tO\nEthiopia\tT-0\n)\tO\n7:38.09\tO\n\n8.\tO\nMartin\tB-PER\nKeino\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n7:38.88\tO\n\n1.\tO\nLars\tT-0\nRiedel\tT-0\n(\tO\nGermany\tB-LOC\n)\tO\n66.74\tO\nmetres\tO\n\n2.\tO\nAnthony\tB-PER\nWashington\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n66.72\tT-1\n\n2.\tO\nAnthony\tO\nWashington\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n66.72\tO\n\n3.\tO\nVladimir\tB-PER\nDubrovshchik\tI-PER\n(\tO\nBelarus\tT-0\n)\tO\n64.02\tO\n\n3.\tO\nVladimir\tT-0\nDubrovshchik\tT-0\n(\tO\nBelarus\tB-LOC\n)\tO\n64.02\tO\n\n4.\tO\nVirgilius\tB-PER\nAlekna\tI-PER\n(\tO\nLithuania\tT-0\n)\tO\n63.62\tO\n\n5.\tO\nJuergen\tB-PER\nSchult\tI-PER\n(\tO\nGermany\tT-0\n)\tO\n63.48\tO\n\n5.\tO\nJuergen\tT-0\nSchult\tT-0\n(\tO\nGermany\tB-LOC\n)\tO\n63.48\tO\n\n7.\tO\nVaclavas\tB-PER\nKidikas\tI-PER\n(\tO\nLithuania\tO\n)\tO\n60.92\tT-0\n\n7.\tO\nVaclavas\tT-1\nKidikas\tO\n(\tO\nLithuania\tB-LOC\n)\tO\n60.92\tT-0\n\n1.\tO\nJonathan\tT-1\nEdwards\tT-1\n(\tO\nBritain\tB-LOC\n)\tO\n17.50\tT-0\nmetres\tT-0\n\n2.\tO\nYoelvis\tB-PER\nQuesada\tI-PER\n(\tO\nCuba\tO\n)\tO\n17.29\tT-0\n\n3.\tO\nBrian\tB-PER\nWellman\tI-PER\n(\tO\nBermuda\tT-0\n)\tO\n17.05\tO\n\n3.\tO\nBrian\tT-0\nWellman\tT-0\n(\tO\nBermuda\tB-LOC\n)\tO\n17.05\tT-1\n\n4.\tO\nKenny\tB-PER\nHarrison\tI-PER\n(\tO\nU.S.\tT-0\n)\tO\n16.97\tO\n\n4.\tO\nKenny\tT-0\nHarrison\tT-0\n(\tO\nU.S.\tB-LOC\n)\tO\n16.97\tO\n\n5.\tO\nGennadi\tT-0\nMarkov\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\n16.66\tO\n\n6.\tO\nFrancis\tB-PER\nAgyepong\tI-PER\n(\tO\nBritain\tT-0\n)\tO\n16.63\tO\n\n6.\tO\nFrancis\tO\nAgyepong\tT-0\n(\tO\nBritain\tB-LOC\n)\tO\n16.63\tO\n\n7.\tO\nRogel\tB-PER\nNachum\tI-PER\n(\tO\nIsrael\tT-1\n)\tO\n16.36\tO\n\n7.\tO\nRogel\tT-0\nNachum\tT-0\n(\tO\nIsrael\tB-LOC\n)\tO\n16.36\tO\n\n8.\tO\nSigurd\tB-PER\nNjerve\tI-PER\n(\tO\nNorway\tT-0\n)\tO\n16.35\tO\n\n1.\tO\nHicham\tB-PER\nEl\tI-PER\nGuerrouj\tI-PER\n(\tO\nMorocco\tO\n)\tO\nthree\tT-0\nminutes\tO\n29.05\tO\nseconds\tO\n\n1.\tO\nHicham\tT-0\nEl\tT-0\nGuerrouj\tT-0\n(\tO\nMorocco\tB-LOC\n)\tO\nthree\tO\nminutes\tO\n29.05\tO\nseconds\tO\n\n3.\tO\nWilliam\tB-PER\nTanui\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n3:33.36\tT-0\n\n3.\tO\nWilliam\tT-0\nTanui\tT-0\n(\tO\nKenya\tB-LOC\n)\tO\n3:33.36\tO\n\n4.\tO\nElijah\tB-PER\nMaru\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n3:33.64\tO\n\n4.\tO\nElijah\tT-0\nMaru\tT-0\n(\tO\nKenya\tB-LOC\n)\tO\n3:33.64\tO\n\n5.\tO\nMarcus\tT-1\nO'Sullivan\tO\n(\tO\nIreland\tB-LOC\n)\tO\n3:33.77\tT-0\n\n6.\tO\nJohn\tB-PER\nMayock\tI-PER\n(\tO\nBritain\tT-0\n)\tO\n3:33.94\tT-1\n\n8.\tO\nChristophe\tB-PER\nImpens\tI-PER\n(\tO\nBelgium\tT-0\n)\tO\n3:34.13\tO\n\n1.\tO\nStefka\tT-0\nKostadinova\tT-0\n(\tO\nBulgaria\tB-LOC\n)\tO\n2.03\tO\nmetres\tO\n\n2.\tO\nInga\tB-PER\nBabakova\tI-PER\n(\tO\nUkraine\tT-0\n)\tO\n2.03\tO\n\n2.\tO\nInga\tO\nBabakova\tT-0\n(\tO\nUkraine\tB-LOC\n)\tO\n2.03\tO\n\n3.\tO\nAlina\tB-PER\nAstafei\tI-PER\n(\tO\nGermany\tT-0\n)\tO\n1.97\tO\n\n3.\tO\nAlina\tT-0\nAstafei\tT-0\n(\tO\nGermany\tB-LOC\n)\tO\n1.97\tO\n\n4.\tO\nTatyana\tB-PER\nMotkova\tI-PER\n(\tO\nRussia\tT-0\n)\tO\n1.94\tO\n\n6.\tO\nYelena\tB-PER\nGulyayeva\tI-PER\n(\tO\nRussia\tT-0\n)\tO\n1.88\tO\n\n6.\tO\nYelena\tT-0\nGulyayeva\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\n1.88\tO\n\n7.\tO\nHanna\tB-PER\nHaugland\tI-PER\n(\tO\nNorway\tT-0\n)\tO\n1.88\tT-1\n\nOlga\tB-PER\nBoshova\tI-PER\n(\tO\nMoldova\tT-0\n)\tO\n1.85\tO\n\n1.\tO\nSalah\tB-PER\nHissou\tI-PER\n(\tO\nMorocco\tT-0\n)\tO\n26\tO\nminutes\tO\n38.08\tO\nseconds\tO\n(\tO\nworld\tO\n\n2.\tO\nPaul\tB-PER\nTergat\tI-PER\n(\tO\nKenya\tT-0\n)\tO\n26:54.41\tO\n\n2.\tO\nPaul\tT-0\nTergat\tT-0\n(\tO\nKenya\tB-LOC\n)\tO\n26:54.41\tO\n\n3.\tO\nPaul\tT-1\nKoech\tT-1\n(\tO\nKenya\tB-LOC\n)\tO\n26:56.78\tT-0\n\n4.\tO\nWilliam\tT-0\nKiptum\tT-0\n(\tO\nKenya\tB-LOC\n)\tO\n27:18.84\tO\n\n6.\tO\nMathias\tB-PER\nNtawulikura\tI-PER\n(\tO\nRwanda\tT-0\n)\tO\n27:25.48\tO\n\n6.\tO\nMathias\tT-0\nNtawulikura\tT-0\n(\tO\nRwanda\tB-LOC\n)\tO\n27:25.48\tO\n\n7.\tO\nAbel\tB-PER\nAnton\tI-PER\n(\tO\nSpain\tT-0\n)\tO\n28:18.44\tT-1\n\n7.\tO\nAbel\tT-0\nAnton\tT-0\n(\tO\nSpain\tB-LOC\n)\tO\n28:18.44\tO\n\n8.\tO\nKamiel\tB-PER\nMaase\tI-PER\n(\tO\nNetherlands\tT-0\n)\tO\n28.29.42\tT-1\n\n8.\tO\nKamiel\tO\nMaase\tO\n(\tO\nNetherlands\tB-LOC\n)\tO\n28.29.42\tT-0\n\n9.\tO\nWorku\tB-PER\nBekila\tI-PER\n(\tO\nEthiopia\tT-0\n)\tO\n28.42.23\tO\n\n9.\tO\nWorku\tT-0\nBekila\tT-0\n(\tO\nEthiopia\tB-LOC\n)\tO\n28.42.23\tO\n\n10.\tO\nRobert\tB-PER\nStefko\tI-PER\n(\tO\nSlovakia\tT-0\n)\tO\n28:42.26\tO\n\n10.\tO\nRobert\tO\nStefko\tO\n(\tO\nSlovakia\tB-LOC\n)\tO\n28:42.26\tT-0\n\nSOCCER\tT-1\n-\tO\nJORGE\tB-PER\nCALLS\tT-0\nUP\tO\nSIX\tO\nPORTO\tO\nPLAYERS\tO\nFOR\tO\nWORLD\tO\nCUP\tO\nQUALIFIER\tO\n.\tO\n\nSOCCER\tO\n-\tO\nJORGE\tO\nCALLS\tT-1\nUP\tT-1\nSIX\tO\nPORTO\tB-ORG\nPLAYERS\tO\nFOR\tO\nWORLD\tO\nCUP\tT-0\nQUALIFIER\tO\n.\tO\n\nSOCCER\tT-1\n-\tO\nJORGE\tO\nCALLS\tO\nUP\tO\nSIX\tO\nPORTO\tO\nPLAYERS\tO\nFOR\tT-0\nWORLD\tB-MISC\nCUP\tI-MISC\nQUALIFIER\tT-2\n.\tO\n\nPortugal\tB-LOC\n's\tT-2\nnew\tO\ncoach\tT-0\nArtur\tO\nJorge\tO\ncalled\tO\nup\tO\nsix\tO\nplayers\tO\nfrom\tO\nleague\tT-1\nchampions\tO\nPorto\tO\non\tO\nFriday\tO\nin\tO\nan\tO\n18-man\tO\nsquad\tO\nfor\tO\nthe\tO\nopening\tO\nWorld\tO\nCup\tO\nqualifier\tO\nagainst\tO\nArmenia\tO\non\tO\nAugust\tO\n31\tO\n.\tO\n\nPortugal\tO\n's\tO\nnew\tO\ncoach\tT-2\nArtur\tB-PER\nJorge\tI-PER\ncalled\tO\nup\tO\nsix\tO\nplayers\tO\nfrom\tO\nleague\tO\nchampions\tT-0\nPorto\tT-0\non\tO\nFriday\tO\nin\tO\nan\tO\n18-man\tO\nsquad\tO\nfor\tO\nthe\tO\nopening\tO\nWorld\tT-1\nCup\tT-1\nqualifier\tO\nagainst\tO\nArmenia\tO\non\tO\nAugust\tO\n31\tO\n.\tO\n\nPortugal\tT-0\n's\tO\nnew\tO\ncoach\tO\nArtur\tT-1\nJorge\tT-1\ncalled\tO\nup\tO\nsix\tO\nplayers\tO\nfrom\tO\nleague\tT-3\nchampions\tT-3\nPorto\tB-ORG\non\tO\nFriday\tO\nin\tO\nan\tO\n18-man\tO\nsquad\tO\nfor\tO\nthe\tO\nopening\tO\nWorld\tO\nCup\tT-2\nqualifier\tO\nagainst\tO\nArmenia\tO\non\tO\nAugust\tO\n31\tO\n.\tO\n\nPortugal\tT-1\n's\tO\nnew\tO\ncoach\tO\nArtur\tT-2\nJorge\tT-2\ncalled\tO\nup\tO\nsix\tO\nplayers\tO\nfrom\tO\nleague\tT-0\nchampions\tT-0\nPorto\tT-3\non\tO\nFriday\tO\nin\tO\nan\tO\n18-man\tO\nsquad\tO\nfor\tO\nthe\tO\nopening\tO\nWorld\tB-MISC\nCup\tI-MISC\nqualifier\tO\nagainst\tO\nArmenia\tT-4\non\tO\nAugust\tO\n31\tO\n.\tO\n\nPortugal\tT-0\n's\tO\nnew\tO\ncoach\tT-2\nArtur\tO\nJorge\tO\ncalled\tO\nup\tO\nsix\tO\nplayers\tO\nfrom\tO\nleague\tO\nchampions\tO\nPorto\tT-1\non\tO\nFriday\tO\nin\tO\nan\tO\n18-man\tO\nsquad\tO\nfor\tO\nthe\tO\nopening\tO\nWorld\tT-3\nCup\tT-3\nqualifier\tO\nagainst\tO\nArmenia\tB-LOC\non\tO\nAugust\tO\n31\tO\n.\tO\n\nMidfielder\tT-0\nPaulo\tB-PER\nSousa\tI-PER\n,\tO\nrecently\tO\ntransferred\tT-1\nto\tO\nBorussia\tO\nDortmund\tO\nfrom\tO\nItaly\tO\n's\tO\nJuventus\tO\n,\tO\nis\tO\nthe\tO\nonly\tO\nleading\tT-2\nmember\tO\nof\tO\nthe\tO\nPortuguese\tO\nside\tO\nfrom\tO\nthis\tO\nyear\tO\n's\tO\nEuropean\tO\nchampionships\tT-3\nwho\tO\nwill\tO\nnot\tO\nmake\tO\nthe\tO\ntrip\tO\n.\tO\n\nMidfielder\tO\nPaulo\tT-0\nSousa\tT-0\n,\tO\nrecently\tO\ntransferred\tT-1\nto\tT-2\nBorussia\tB-ORG\nDortmund\tI-ORG\nfrom\tO\nItaly\tO\n's\tO\nJuventus\tT-3\n,\tO\nis\tO\nthe\tO\nonly\tO\nleading\tO\nmember\tO\nof\tO\nthe\tO\nPortuguese\tO\nside\tO\nfrom\tO\nthis\tO\nyear\tO\n's\tO\nEuropean\tO\nchampionships\tO\nwho\tO\nwill\tO\nnot\tO\nmake\tO\nthe\tO\ntrip\tO\n.\tO\n\nMidfielder\tT-3\nPaulo\tT-3\nSousa\tT-3\n,\tO\nrecently\tT-1\ntransferred\tT-1\nto\tO\nBorussia\tT-4\nDortmund\tT-4\nfrom\tT-0\nItaly\tB-LOC\n's\tO\nJuventus\tO\n,\tO\nis\tO\nthe\tO\nonly\tO\nleading\tT-2\nmember\tT-2\nof\tO\nthe\tO\nPortuguese\tT-5\nside\tO\nfrom\tO\nthis\tO\nyear\tO\n's\tO\nEuropean\tO\nchampionships\tO\nwho\tO\nwill\tO\nnot\tO\nmake\tO\nthe\tO\ntrip\tO\n.\tO\n\nMidfielder\tT-1\nPaulo\tT-1\nSousa\tT-1\n,\tO\nrecently\tO\ntransferred\tT-3\nto\tO\nBorussia\tO\nDortmund\tO\nfrom\tT-2\nItaly\tT-2\n's\tT-2\nJuventus\tB-ORG\n,\tO\nis\tO\nthe\tO\nonly\tO\nleading\tO\nmember\tO\nof\tO\nthe\tO\nPortuguese\tO\nside\tO\nfrom\tO\nthis\tO\nyear\tO\n's\tO\nEuropean\tO\nchampionships\tO\nwho\tO\nwill\tO\nnot\tO\nmake\tO\nthe\tO\ntrip\tO\n.\tO\n\nMidfielder\tT-1\nPaulo\tT-1\nSousa\tT-1\n,\tO\nrecently\tO\ntransferred\tO\nto\tO\nBorussia\tO\nDortmund\tO\nfrom\tO\nItaly\tO\n's\tO\nJuventus\tO\n,\tO\nis\tO\nthe\tO\nonly\tO\nleading\tO\nmember\tT-0\nof\tT-3\nthe\tT-3\nPortuguese\tB-MISC\nside\tO\nfrom\tO\nthis\tO\nyear\tO\n's\tO\nEuropean\tT-2\nchampionships\tT-2\nwho\tO\nwill\tO\nnot\tO\nmake\tO\nthe\tO\ntrip\tO\n.\tO\n\nMidfielder\tT-1\nPaulo\tT-1\nSousa\tT-1\n,\tO\nrecently\tO\ntransferred\tT-5\nto\tO\nBorussia\tT-2\nDortmund\tT-2\nfrom\tO\nItaly\tT-3\n's\tO\nJuventus\tT-4\n,\tO\nis\tO\nthe\tO\nonly\tO\nleading\tO\nmember\tT-6\nof\tO\nthe\tO\nPortuguese\tO\nside\tO\nfrom\tO\nthis\tO\nyear\tO\n's\tO\nEuropean\tB-MISC\nchampionships\tT-0\nwho\tO\nwill\tO\nnot\tO\nmake\tO\nthe\tO\ntrip\tO\n.\tO\n\nIt\tO\nwill\tO\nbe\tO\nJorge\tB-PER\n's\tO\nfirst\tO\ngame\tO\nin\tO\ncharge\tT-2\nof\tO\nthe\tO\nnational\tT-0\nsquad\tT-0\nsince\tO\ntaking\tT-1\nover\tT-1\nfrom\tO\nAntonio\tT-3\nOliveira\tT-3\n,\tO\nwho\tO\nnow\tO\ncoaches\tO\nPorto\tT-4\n,\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nEuro\tT-5\n96\tT-5\n.\tO\n\nIt\tO\nwill\tO\nbe\tO\nJorge\tT-2\n's\tO\nfirst\tO\ngame\tO\nin\tO\ncharge\tO\nof\tO\nthe\tO\nnational\tO\nsquad\tO\nsince\tO\ntaking\tT-0\nover\tO\nfrom\tO\nAntonio\tB-PER\nOliveira\tI-PER\n,\tO\nwho\tO\nnow\tO\ncoaches\tT-1\nPorto\tT-1\n,\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nEuro\tO\n96\tO\n.\tO\n\nIt\tO\nwill\tO\nbe\tO\nJorge\tT-0\n's\tT-0\nfirst\tO\ngame\tO\nin\tO\ncharge\tO\nof\tO\nthe\tO\nnational\tO\nsquad\tO\nsince\tO\ntaking\tO\nover\tO\nfrom\tO\nAntonio\tT-1\nOliveira\tT-1\n,\tO\nwho\tO\nnow\tO\ncoaches\tT-2\nPorto\tB-ORG\n,\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nEuro\tO\n96\tO\n.\tO\n\nIt\tO\nwill\tO\nbe\tO\nJorge\tO\n's\tO\nfirst\tT-1\ngame\tT-1\nin\tO\ncharge\tO\nof\tO\nthe\tO\nnational\tO\nsquad\tO\nsince\tO\ntaking\tO\nover\tO\nfrom\tO\nAntonio\tO\nOliveira\tO\n,\tO\nwho\tO\nnow\tO\ncoaches\tT-2\nPorto\tT-0\n,\tO\nat\tO\nthe\tO\nend\tO\nof\tO\nEuro\tB-MISC\n96\tI-MISC\n.\tO\n\nGoalkeepers\tO\n-\tO\nVitor\tB-PER\nBaia\tI-PER\n,\tO\nRui\tT-0\nCorreia\tT-0\n.\tO\n\nGoalkeepers\tT-0\n-\tO\nVitor\tT-1\nBaia\tT-1\n,\tO\nRui\tB-PER\nCorreia\tI-PER\n.\tO\n\nDefenders\tO\n-\tO\nJorge\tT-0\nCosta\tT-0\n,\tO\nPaulinho\tB-PER\nSantos\tI-PER\n,\tO\nHelder\tT-1\nCristovao\tT-1\n,\tO\nCarlos\tO\nSecretario\tO\n,\tO\nDimas\tO\nTeixeira\tO\n,\tO\nFernando\tO\nCouto\tO\n.\tO\n\nDefenders\tT-0\n-\tO\nJorge\tT-1\nCosta\tT-1\n,\tO\nPaulinho\tT-2\nSantos\tT-2\n,\tO\nHelder\tB-PER\nCristovao\tI-PER\n,\tO\nCarlos\tT-3\nSecretario\tT-3\n,\tO\nDimas\tT-4\nTeixeira\tT-4\n,\tO\nFernando\tT-5\nCouto\tT-5\n.\tT-5\n\nDefenders\tT-0\n-\tO\nJorge\tT-1\nCosta\tT-1\n,\tO\nPaulinho\tT-2\nSantos\tT-2\n,\tO\nHelder\tT-3\nCristovao\tT-3\n,\tO\nCarlos\tB-PER\nSecretario\tI-PER\n,\tO\nDimas\tO\nTeixeira\tO\n,\tO\nFernando\tO\nCouto\tO\n.\tO\n\nDefenders\tT-0\n-\tO\nJorge\tO\nCosta\tO\n,\tO\nPaulinho\tO\nSantos\tO\n,\tO\nHelder\tO\nCristovao\tO\n,\tO\nCarlos\tO\nSecretario\tO\n,\tO\nDimas\tB-PER\nTeixeira\tI-PER\n,\tO\nFernando\tT-1\nCouto\tO\n.\tO\n\nMidfielders\tO\n-\tO\nJose\tB-PER\nBarroso\tI-PER\n,\tO\nLuis\tT-0\nFigo\tT-0\n,\tO\nRui\tT-1\nBarros\tT-1\n,\tO\nRui\tO\nCosta\tT-2\n,\tO\nOceano\tT-3\nCruz\tO\n,\tO\nRicardo\tO\nSa\tO\nPinto\tO\n.\tO\n\nMidfielders\tT-0\n-\tO\nJose\tT-1\nBarroso\tT-1\n,\tO\nLuis\tB-PER\nFigo\tI-PER\n,\tO\nRui\tO\nBarros\tO\n,\tO\nRui\tO\nCosta\tO\n,\tO\nOceano\tO\nCruz\tO\n,\tO\nRicardo\tO\nSa\tO\nPinto\tO\n.\tO\n\nMidfielders\tT-2\n-\tO\nJose\tT-0\nBarroso\tT-1\n,\tO\nLuis\tO\nFigo\tO\n,\tO\nRui\tB-PER\nBarros\tI-PER\n,\tO\nRui\tO\nCosta\tO\n,\tO\nOceano\tO\nCruz\tO\n,\tO\nRicardo\tO\nSa\tO\nPinto\tO\n.\tO\n\nMidfielders\tO\n-\tO\nJose\tO\nBarroso\tO\n,\tO\nLuis\tO\nFigo\tO\n,\tO\nRui\tO\nBarros\tO\n,\tO\nRui\tT-0\nCosta\tT-0\n,\tO\nOceano\tB-PER\nCruz\tI-PER\n,\tO\nRicardo\tT-1\nSa\tT-1\nPinto\tT-1\n.\tO\n\nMidfielders\tT-0\n-\tO\nJose\tO\nBarroso\tO\n,\tO\nLuis\tO\nFigo\tO\n,\tO\nRui\tO\nBarros\tO\n,\tO\nRui\tO\nCosta\tO\n,\tO\nOceano\tO\nCruz\tO\n,\tO\nRicardo\tB-PER\nSa\tI-PER\nPinto\tI-PER\n.\tO\n\nForwards\tT-0\n-\tO\nDomingos\tB-PER\nOliveira\tI-PER\n,\tO\nJoao\tT-1\nVieira\tT-1\nPinto\tT-1\n,\tO\nJorge\tT-2\nCadete\tT-2\n,\tO\nAntonio\tT-3\nFolha\tT-3\n.\tO\n\nForwards\tT-1\n-\tO\nDomingos\tT-0\nOliveira\tT-0\n,\tO\nJoao\tO\nVieira\tO\nPinto\tO\n,\tO\nJorge\tB-PER\nCadete\tI-PER\n,\tO\nAntonio\tO\nFolha\tO\n.\tO\n\nForwards\tT-0\n-\tO\nDomingos\tT-1\nOliveira\tT-1\n,\tO\nJoao\tT-2\nVieira\tT-2\nPinto\tT-2\n,\tO\nJorge\tO\nCadete\tO\n,\tO\nAntonio\tB-PER\nFolha\tI-PER\n.\tO\n\nSOCCER\tO\n-\tO\nVOGTS\tB-PER\nKEEPS\tT-1\nFAITH\tT-0\nWITH\tT-2\nEURO\tT-2\n'\tT-2\n96\tT-2\nCHAMPIONS\tT-2\n.\tO\n\nSOCCER\tO\n-\tO\nVOGTS\tT-0\nKEEPS\tT-0\nFAITH\tT-0\nWITH\tT-0\nEURO\tB-MISC\n'\tI-MISC\n96\tI-MISC\nCHAMPIONS\tO\n.\tO\n\nTrainer\tT-3\nBerti\tB-PER\nVogts\tI-PER\nkept\tO\nfaith\tO\nwith\tO\nhis\tO\nentire\tO\nEuropean\tT-2\nchampionship\tT-2\nwinning\tO\nsquad\tO\nfor\tO\nGermany\tT-1\n's\tO\nfirst\tO\nmatch\tO\nsince\tO\ntheir\tO\ntitle\tO\nvictory\tO\n,\tO\na\tO\nfriendly\tO\nin\tO\nPoland\tO\n.\tO\n\nTrainer\tO\nBerti\tO\nVogts\tO\nkept\tT-0\nfaith\tO\nwith\tO\nhis\tO\nentire\tO\nEuropean\tB-MISC\nchampionship\tO\nwinning\tT-1\nsquad\tO\nfor\tO\nGermany\tO\n's\tO\nfirst\tT-3\nmatch\tT-3\nsince\tO\ntheir\tO\ntitle\tO\nvictory\tT-2\n,\tO\na\tO\nfriendly\tO\nin\tO\nPoland\tO\n.\tO\n\nTrainer\tO\nBerti\tO\nVogts\tO\nkept\tO\nfaith\tO\nwith\tO\nhis\tO\nentire\tT-0\nEuropean\tO\nchampionship\tT-1\nwinning\tO\nsquad\tO\nfor\tO\nGermany\tB-LOC\n's\tO\nfirst\tO\nmatch\tO\nsince\tO\ntheir\tO\ntitle\tO\nvictory\tO\n,\tO\na\tO\nfriendly\tO\nin\tO\nPoland\tO\n.\tO\n\nTrainer\tT-1\nBerti\tT-1\nVogts\tT-1\nkept\tO\nfaith\tO\nwith\tO\nhis\tO\nentire\tO\nEuropean\tT-2\nchampionship\tO\nwinning\tO\nsquad\tT-4\nfor\tO\nGermany\tO\n's\tO\nfirst\tO\nmatch\tO\nsince\tO\ntheir\tO\ntitle\tO\nvictory\tT-3\n,\tO\na\tO\nfriendly\tO\nin\tT-0\nPoland\tB-LOC\n.\tO\n\nVogts\tB-PER\npicked\tO\nno\tO\nnew\tO\nplayers\tT-0\nfor\tO\nthe\tO\nsquad\tT-1\nfor\tO\nthe\tO\nSeptember\tO\n4\tT-2\ngame\tT-2\nin\tO\nZabrze\tO\n.\tO\n\nVogts\tO\npicked\tO\nno\tO\nnew\tO\nplayers\tO\nfor\tO\nthe\tO\nsquad\tO\nfor\tO\nthe\tO\nSeptember\tT-0\n4\tO\ngame\tO\nin\tO\nZabrze\tB-LOC\n.\tO\n\nInstead\tO\non\tO\nFriday\tT-1\nhe\tO\nnominated\tO\nall\tO\n23\tO\nEuro\tB-MISC\n'\tI-MISC\n96\tI-MISC\nveterans\tT-2\nincluding\tT-0\nBremen\tO\n's\tO\nJens\tO\nTodt\tO\n,\tO\ncalled\tO\nup\tO\nbefore\tO\nthe\tO\nfinal\tO\nby\tO\nspecial\tO\nUEFA\tO\ndispensation\tO\n.\tO\n\nInstead\tO\non\tO\nFriday\tO\nhe\tO\nnominated\tO\nall\tO\n23\tT-0\nEuro\tT-0\n'\tT-0\n96\tT-0\nveterans\tO\nincluding\tT-2\nBremen\tB-ORG\n's\tT-1\nJens\tT-1\nTodt\tT-1\n,\tO\ncalled\tO\nup\tO\nbefore\tO\nthe\tO\nfinal\tO\nby\tO\nspecial\tO\nUEFA\tT-3\ndispensation\tT-3\n.\tO\n\nInstead\tO\non\tO\nFriday\tO\nhe\tO\nnominated\tO\nall\tO\n23\tO\nEuro\tO\n'\tO\n96\tO\nveterans\tO\nincluding\tT-1\nBremen\tT-2\n's\tT-2\nJens\tB-PER\nTodt\tI-PER\n,\tO\ncalled\tT-0\nup\tO\nbefore\tO\nthe\tO\nfinal\tO\nby\tO\nspecial\tT-3\nUEFA\tT-3\ndispensation\tT-3\n.\tO\n\nInstead\tO\non\tO\nFriday\tO\nhe\tO\nnominated\tT-0\nall\tO\n23\tO\nEuro\tO\n'\tO\n96\tO\nveterans\tO\nincluding\tO\nBremen\tO\n's\tO\nJens\tO\nTodt\tO\n,\tO\ncalled\tO\nup\tO\nbefore\tO\nthe\tO\nfinal\tO\nby\tO\nspecial\tT-1\nUEFA\tB-ORG\ndispensation\tT-2\n.\tO\n\nHe\tO\nwill\tO\n,\tO\nhowever\tO\n,\tO\nhave\tO\nto\tO\ndo\tO\nwithout\tO\nthe\tO\nDortmund\tB-ORG\ntrio\tT-1\nof\tT-1\nlibero\tT-2\nMatthias\tT-2\nSammer\tT-2\n,\tO\nmidfielder\tT-0\nSteffen\tO\nFreund\tO\nand\tO\ndefender\tT-3\nRene\tT-3\nSchneider\tT-3\n,\tO\nwho\tO\nwere\tO\nall\tO\nformally\tO\nnominated\tO\ndespite\tO\nbeing\tO\ninjured\tO\n.\tO\n\nHe\tO\nwill\tO\n,\tO\nhowever\tO\n,\tO\nhave\tO\nto\tO\ndo\tO\nwithout\tO\nthe\tO\nDortmund\tO\ntrio\tT-0\nof\tO\nlibero\tO\nMatthias\tB-PER\nSammer\tI-PER\n,\tO\nmidfielder\tO\nSteffen\tT-1\nFreund\tT-1\nand\tO\ndefender\tO\nRene\tT-2\nSchneider\tT-2\n,\tO\nwho\tO\nwere\tO\nall\tO\nformally\tO\nnominated\tO\ndespite\tO\nbeing\tO\ninjured\tO\n.\tO\n\nHe\tO\nwill\tO\n,\tO\nhowever\tO\n,\tO\nhave\tO\nto\tO\ndo\tO\nwithout\tO\nthe\tO\nDortmund\tO\ntrio\tO\nof\tO\nlibero\tO\nMatthias\tT-0\nSammer\tT-0\n,\tO\nmidfielder\tT-1\nSteffen\tB-PER\nFreund\tI-PER\nand\tO\ndefender\tO\nRene\tO\nSchneider\tO\n,\tO\nwho\tO\nwere\tO\nall\tO\nformally\tO\nnominated\tO\ndespite\tO\nbeing\tO\ninjured\tO\n.\tO\n\nHe\tO\nwill\tO\n,\tO\nhowever\tO\n,\tO\nhave\tO\nto\tO\ndo\tO\nwithout\tO\nthe\tO\nDortmund\tT-0\ntrio\tO\nof\tO\nlibero\tO\nMatthias\tT-1\nSammer\tT-1\n,\tO\nmidfielder\tO\nSteffen\tT-2\nFreund\tT-2\nand\tO\ndefender\tO\nRene\tB-PER\nSchneider\tI-PER\n,\tO\nwho\tT-3\nwere\tO\nall\tO\nformally\tO\nnominated\tO\ndespite\tO\nbeing\tO\ninjured\tO\n.\tO\n\n\"\tO\nThis\tO\nsquad\tT-2\nis\tO\ncurrently\tO\nthe\tO\nbasis\tO\nof\tO\nmy\tO\nplanning\tT-1\nfor\tO\nthe\tO\n1998\tT-0\nWorld\tB-MISC\nCup\tI-MISC\n,\tO\n\"\tO\nVogts\tO\nsaid\tO\n.\tO\n\"\tO\n\n\"\tO\nThis\tO\nsquad\tT-0\nis\tO\ncurrently\tO\nthe\tO\nbasis\tO\nof\tO\nmy\tO\nplanning\tO\nfor\tO\nthe\tO\n1998\tO\nWorld\tT-1\nCup\tT-1\n,\tO\n\"\tO\nVogts\tB-PER\nsaid\tT-2\n.\tO\n\"\tO\n\nGoalkeepers\tO\n-\tO\nOliver\tB-PER\nKahn\tI-PER\n,\tO\nAndreas\tT-0\nKoepke\tT-0\n,\tO\nOliver\tO\nReck\tO\n\nGoalkeepers\tT-0\n-\tO\nOliver\tO\nKahn\tO\n,\tO\nAndreas\tO\nKoepke\tO\n,\tO\nOliver\tB-PER\nReck\tI-PER\n\nDefenders\tO\n-\tO\nMarkus\tB-PER\nBabbel\tI-PER\n,\tO\nThomas\tT-0\nHelmer\tT-0\n,\tO\nJuergen\tO\nKohler\tO\n,\tO\nStefan\tO\nReuter\tO\n,\tO\nMatthias\tO\nSammer\tO\n,\tO\nRene\tO\nSchneider\tO\n\nDefenders\tT-0\n-\tO\nMarkus\tT-1\nBabbel\tT-1\n,\tO\nThomas\tB-PER\nHelmer\tI-PER\n,\tO\nJuergen\tT-2\nKohler\tT-2\n,\tO\nStefan\tT-3\nReuter\tT-3\n,\tO\nMatthias\tT-4\nSammer\tT-4\n,\tO\nRene\tT-5\nSchneider\tT-5\n\nDefenders\tO\n-\tO\nMarkus\tT-0\nBabbel\tT-0\n,\tO\nThomas\tT-1\nHelmer\tT-1\n,\tO\nJuergen\tT-2\nKohler\tT-2\n,\tO\nStefan\tB-PER\nReuter\tI-PER\n,\tO\nMatthias\tT-3\nSammer\tT-3\n,\tO\nRene\tT-4\nSchneider\tT-4\n\nDefenders\tT-0\n-\tO\nMarkus\tO\nBabbel\tO\n,\tO\nThomas\tO\nHelmer\tO\n,\tO\nJuergen\tO\nKohler\tO\n,\tO\nStefan\tO\nReuter\tO\n,\tO\nMatthias\tB-PER\nSammer\tI-PER\n,\tO\nRene\tT-1\nSchneider\tT-1\n\nDefenders\tO\n-\tO\nMarkus\tT-3\nBabbel\tT-3\n,\tO\nThomas\tO\nHelmer\tT-0\n,\tO\nJuergen\tT-1\nKohler\tT-1\n,\tO\nStefan\tT-2\nReuter\tT-2\n,\tO\nMatthias\tO\nSammer\tO\n,\tO\nRene\tB-PER\nSchneider\tI-PER\n\nMidfielders\tT-0\n-\tO\nMario\tB-PER\nBasler\tI-PER\n,\tO\nMarco\tT-5\nBode\tT-5\n,\tO\nDieter\tT-6\nEilts\tT-6\n,\tO\nSteffen\tT-1\nFreund\tT-1\n,\tO\nThomas\tT-7\nHaessler\tT-7\n,\tO\nAndreas\tT-8\nMoeller\tT-8\n,\tO\nMehmet\tT-2\nScholl\tT-2\n,\tO\nThomas\tT-3\nStrunz\tT-3\n,\tO\nJens\tT-4\nTodt\tT-4\n,\tO\nChristian\tT-9\nZiege\tT-9\n\nMidfielders\tO\n-\tO\nMario\tT-0\nBasler\tT-0\n,\tO\nMarco\tB-PER\nBode\tI-PER\n,\tO\nDieter\tO\nEilts\tO\n,\tO\nSteffen\tO\nFreund\tO\n,\tO\nThomas\tO\nHaessler\tO\n,\tO\nAndreas\tO\nMoeller\tO\n,\tO\nMehmet\tO\nScholl\tO\n,\tO\nThomas\tO\nStrunz\tO\n,\tO\nJens\tO\nTodt\tO\n,\tO\nChristian\tO\nZiege\tO\n\nMidfielders\tO\n-\tO\nMario\tT-0\nBasler\tT-0\n,\tO\nMarco\tT-1\nBode\tT-1\n,\tO\nDieter\tB-PER\nEilts\tI-PER\n,\tO\nSteffen\tT-2\nFreund\tT-2\n,\tO\nThomas\tO\nHaessler\tO\n,\tO\nAndreas\tO\nMoeller\tO\n,\tO\nMehmet\tO\nScholl\tO\n,\tO\nThomas\tO\nStrunz\tO\n,\tO\nJens\tO\nTodt\tO\n,\tO\nChristian\tO\nZiege\tO\n\nMidfielders\tT-2\n-\tO\nMario\tO\nBasler\tO\n,\tO\nMarco\tO\nBode\tO\n,\tO\nDieter\tT-0\nEilts\tT-0\n,\tO\nSteffen\tB-PER\nFreund\tI-PER\n,\tO\nThomas\tT-1\nHaessler\tT-1\n,\tO\nAndreas\tO\nMoeller\tO\n,\tO\nMehmet\tO\nScholl\tO\n,\tO\nThomas\tO\nStrunz\tO\n,\tO\nJens\tO\nTodt\tO\n,\tO\nChristian\tO\nZiege\tO\n\nMidfielders\tO\n-\tO\nMario\tO\nBasler\tO\n,\tO\nMarco\tO\nBode\tO\n,\tO\nDieter\tO\nEilts\tO\n,\tO\nSteffen\tT-0\nFreund\tT-0\n,\tO\nThomas\tB-PER\nHaessler\tI-PER\n,\tT-1\nAndreas\tT-1\nMoeller\tT-1\n,\tO\nMehmet\tO\nScholl\tO\n,\tO\nThomas\tO\nStrunz\tO\n,\tO\nJens\tO\nTodt\tO\n,\tO\nChristian\tO\nZiege\tO\n\nMidfielders\tT-0\n-\tO\nMario\tO\nBasler\tO\n,\tO\nMarco\tO\nBode\tO\n,\tO\nDieter\tO\nEilts\tO\n,\tO\nSteffen\tO\nFreund\tO\n,\tO\nThomas\tO\nHaessler\tO\n,\tO\nAndreas\tT-1\nMoeller\tO\n,\tO\nMehmet\tB-PER\nScholl\tI-PER\n,\tO\nThomas\tO\nStrunz\tO\n,\tO\nJens\tO\nTodt\tO\n,\tO\nChristian\tO\nZiege\tT-1\n\nMidfielders\tT-0\n-\tO\nMario\tO\nBasler\tO\n,\tO\nMarco\tO\nBode\tO\n,\tO\nDieter\tO\nEilts\tO\n,\tO\nSteffen\tO\nFreund\tO\n,\tO\nThomas\tO\nHaessler\tO\n,\tO\nAndreas\tO\nMoeller\tO\n,\tO\nMehmet\tO\nScholl\tO\n,\tO\nThomas\tB-PER\nStrunz\tI-PER\n,\tO\nJens\tO\nTodt\tO\n,\tO\nChristian\tO\nZiege\tO\n\nMidfielders\tT-0\n-\tO\nMario\tT-1\nBasler\tT-1\n,\tO\nMarco\tT-2\nBode\tT-2\n,\tO\nDieter\tT-3\nEilts\tT-3\n,\tO\nSteffen\tO\nFreund\tO\n,\tO\nThomas\tO\nHaessler\tO\n,\tO\nAndreas\tO\nMoeller\tO\n,\tO\nMehmet\tO\nScholl\tO\n,\tO\nThomas\tO\nStrunz\tO\n,\tO\nJens\tB-PER\nTodt\tI-PER\n,\tO\nChristian\tO\nZiege\tO\n\nMidfielders\tO\n-\tO\nMario\tO\nBasler\tO\n,\tO\nMarco\tO\nBode\tO\n,\tO\nDieter\tO\nEilts\tO\n,\tO\nSteffen\tO\nFreund\tO\n,\tO\nThomas\tO\nHaessler\tO\n,\tO\nAndreas\tO\nMoeller\tO\n,\tO\nMehmet\tO\nScholl\tO\n,\tO\nThomas\tT-0\nStrunz\tT-0\n,\tO\nJens\tT-1\nTodt\tT-1\n,\tO\nChristian\tB-PER\nZiege\tI-PER\n\nForwards\tT-1\n-\tO\nOliver\tB-PER\nBierhoff\tI-PER\n,\tO\nFredi\tT-0\nBobic\tT-0\n,\tO\nJuergen\tO\nKlinsmann\tO\n,\tO\nStefan\tO\nKuntz\tO\n.\tO\n\nForwards\tT-0\n-\tO\nOliver\tO\nBierhoff\tO\n,\tO\nFredi\tB-PER\nBobic\tI-PER\n,\tO\nJuergen\tT-1\nKlinsmann\tT-1\n,\tO\nStefan\tT-2\nKuntz\tT-2\n.\tO\n\nForwards\tO\n-\tO\nOliver\tT-0\nBierhoff\tT-0\n,\tO\nFredi\tT-1\nBobic\tT-1\n,\tO\nJuergen\tT-2\nKlinsmann\tT-2\n,\tO\nStefan\tB-PER\nKuntz\tI-PER\n.\tO\n\nSOCCER\tT-1\n-\tO\nEUROPEAN\tB-MISC\nCUP\tI-MISC\nDRAWS\tT-3\nFOR\tO\nAEK\tO\n,\tO\nOLYMPIAKOS\tT-2\n,\tO\nPAO\tO\n.\tO\n\nSOCCER\tO\n-\tO\nEUROPEAN\tO\nCUP\tT-1\nDRAWS\tT-0\nFOR\tT-0\nAEK\tB-ORG\n,\tO\nOLYMPIAKOS\tO\n,\tO\nPAO\tO\n.\tO\n\nSOCCER\tO\n-\tO\nEUROPEAN\tO\nCUP\tO\nDRAWS\tO\nFOR\tO\nAEK\tO\n,\tO\nOLYMPIAKOS\tB-ORG\n,\tO\nPAO\tT-0\n.\tO\n\nSOCCER\tT-0\n-\tO\nEUROPEAN\tO\nCUP\tT-1\nDRAWS\tO\nFOR\tO\nAEK\tO\n,\tO\nOLYMPIAKOS\tT-2\n,\tO\nPAO\tB-ORG\n.\tO\n\nFollowing\tT-0\nare\tO\nthe\tO\nEuropean\tB-MISC\nsoccer\tO\n\ndraws\tT-0\nfor\tO\nthe\tO\nUEFA\tB-ORG\ncup\tT-2\nand\tO\nthe\tO\ncup\tO\n's\tO\nwinners\tO\ncup\tO\ninvolving\tO\nGreek\tT-1\n\ndraws\tO\nfor\tO\nthe\tO\nUEFA\tO\ncup\tT-0\nand\tO\nthe\tO\ncup\tT-1\n's\tT-1\nwinners\tT-1\ncup\tO\ninvolving\tT-2\nGreek\tB-MISC\n\nteams\tT-0\nthat\tO\ntook\tT-2\nplace\tT-1\ntoday\tO\nin\tO\nGeneva\tB-LOC\n:\tO\n\nx-AEK\tB-ORG\nAthens\tI-ORG\n(\tO\nGreece\tT-0\n)\tO\nv\tO\nChemlon\tT-2\nHumenne\tT-2\n(\tO\nSlovakia\tT-1\n)\tO\n\nx-AEK\tO\nAthens\tO\n(\tO\nGreece\tB-LOC\n)\tO\nv\tT-0\nChemlon\tO\nHumenne\tO\n(\tO\nSlovakia\tO\n)\tO\n\nx-AEK\tO\nAthens\tT-0\n(\tO\nGreece\tO\n)\tO\nv\tO\nChemlon\tB-ORG\nHumenne\tI-ORG\n(\tO\nSlovakia\tO\n)\tT-0\n\nx-AEK\tO\nAthens\tT-0\n(\tO\nGreece\tO\n)\tO\nv\tO\nChemlon\tO\nHumenne\tO\n(\tO\nSlovakia\tB-LOC\n)\tO\n\nx-Olympiakos\tB-ORG\nv\tT-0\nFerencvaros\tO\n(\tO\nHungary\tT-1\n)\tO\n\nx-Olympiakos\tO\nv\tT-1\nFerencvaros\tB-ORG\n(\tO\nHungary\tT-0\n)\tO\n\nx-Olympiakos\tO\nv\tO\nFerencvaros\tT-0\n(\tO\nHungary\tB-LOC\n)\tO\n\nx-PAO\tB-ORG\nv\tO\nLegia\tT-0\nWarsaw\tT-0\n(\tO\nPoland\tO\n)\tO\n\nx-PAO\tT-0\nv\tO\nLegia\tT-1\nWarsaw\tT-1\n(\tO\nPoland\tB-LOC\n)\tO\n\n--\tO\nDimitris\tB-PER\nKontogiannis\tI-PER\n,\tO\nAthens\tT-0\nNewsroom\tT-0\n+301\tO\n3311812-4\tO\n\n--\tO\nDimitris\tT-0\nKontogiannis\tT-0\n,\tO\nAthens\tB-ORG\nNewsroom\tI-ORG\n+301\tT-1\n3311812-4\tT-1\n\nSOCCER\tO\n-\tO\nEURO\tB-MISC\nCLUB\tO\nCOMPETITION\tT-0\nFIRST\tO\nROUND\tO\nDRAWS\tO\n.\tO\n\nDraws\tO\nfor\tO\nthe\tO\nfirst\tO\nround\tO\nof\tO\nthe\tO\nEuropean\tB-MISC\nclub\tT-0\nsoccer\tT-2\ncompetitions\tT-1\nmade\tO\non\tO\nFriday\tO\n(\tO\nx\tO\ndenotes\tO\nseeded\tO\nteam\tO\n)\tO\n:\tO\n\nUEFA\tB-MISC\nCup\tI-MISC\nLyngby\tT-0\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tT-1\nGraz\tT-1\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tT-2\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tT-3\nVladikavkaz\tT-3\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tO\nCup\tO\nLyngby\tO\n(\tO\nDenmark\tB-LOC\n)\tO\nv\tT-0\nx-Club\tT-0\nBrugge\tT-0\n(\tO\nBelgium\tO\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tT-1\nCup\tT-1\nLyngby\tO\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tB-ORG\nBrugge\tI-ORG\n(\tO\nBelgium\tT-0\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tO\nCup\tO\nLyngby\tT-0\n(\tT-0\nDenmark\tT-0\n)\tT-0\nv\tT-2\nx-Club\tO\nBrugge\tT-1\n(\tO\nBelgium\tB-LOC\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tT-1\n\nUEFA\tT-0\nCup\tT-0\nLyngby\tO\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tB-ORG\nGraz\tI-ORG\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tT-3\nCup\tT-3\nLyngby\tT-3\n(\tO\nDenmark\tT-0\n)\tO\nv\tT-4\nx-Club\tT-4\nBrugge\tT-4\n(\tO\nBelgium\tT-1\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tB-LOC\n)\tO\nv\tT-5\nEkeren\tT-5\n(\tO\nBelgium\tT-2\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tT-2\nCup\tT-2\nLyngby\tT-2\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tT-0\nEkeren\tB-ORG\n(\tO\nBelgium\tT-1\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tO\nCup\tO\nLyngby\tO\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tT-0\n(\tO\nBelgium\tB-LOC\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tT-0\nCup\tT-0\nLyngby\tO\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tB-ORG\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tO\nCup\tT-1\nLyngby\tO\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tB-LOC\n)\tO\nv\tT-0\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tT-0\nCup\tT-0\nLyngby\tT-0\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tB-ORG\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tO\nCup\tO\nLyngby\tO\n(\tO\nDenmark\tT-1\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tT-2\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tT-4\n(\tO\nTurkey\tT-3\n)\tO\nv\tT-5\nMolenbeek\tT-5\n(\tO\nBelgium\tB-LOC\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tO\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tO\nCup\tO\nLyngby\tO\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tT-0\n)\tO\nAlania\tB-ORG\nVladikavkaz\tI-ORG\n(\tT-1\nRussia\tT-1\n)\tT-1\nv\tT-1\nx-Anderlecht\tT-1\n(\tT-1\nBelgium\tT-1\n)\tT-1\n\nUEFA\tT-2\nCup\tT-2\nLyngby\tO\n(\tO\nDenmark\tO\n)\tO\nv\tO\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tO\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tT-0\nVladikavkaz\tT-0\n(\tO\nRussia\tB-LOC\n)\tO\nv\tT-1\nx-Anderlecht\tO\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tT-0\nCup\tT-0\nLyngby\tO\n(\tO\nDenmark\tO\n)\tO\nv\tT-1\nx-Club\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nCasino\tO\nGraz\tO\n(\tO\nAustria\tO\n)\tO\nv\tT-2\nEkeren\tO\n(\tO\nBelgium\tO\n)\tO\nBesiktas\tO\n(\tO\nTurkey\tO\n)\tO\nv\tO\nMolenbeek\tO\n(\tO\nBelgium\tO\n)\tO\nAlania\tO\nVladikavkaz\tO\n(\tO\nRussia\tO\n)\tO\nv\tT-3\nx-Anderlecht\tB-ORG\n(\tO\nBelgium\tO\n)\tO\n\nUEFA\tT-3\nCup\tT-3\nLyngby\tT-16\n(\tO\nDenmark\tT-4\n)\tO\nv\tT-11\nx-Club\tT-11\nBrugge\tT-11\n(\tO\nBelgium\tT-5\n)\tO\nCasino\tT-12\nGraz\tT-12\n(\tO\nAustria\tT-6\n)\tO\nv\tO\nEkeren\tT-13\n(\tO\nBelgium\tT-7\n)\tO\nBesiktas\tT-1\n(\tO\nTurkey\tT-8\n)\tO\nv\tO\nMolenbeek\tT-14\n(\tO\nBelgium\tT-9\n)\tO\nAlania\tT-2\nVladikavkaz\tT-2\n(\tO\nRussia\tT-10\n)\tO\nv\tT-15\nx-Anderlecht\tT-15\n(\tO\nBelgium\tB-LOC\n)\tO\n\nCup\tB-MISC\nWinners\tI-MISC\n'\tI-MISC\nCup\tI-MISC\nx-Cercle\tT-0\nBrugge\tT-0\n(\tO\nBelgium\tO\n)\tO\nv\tT-1\nBrann\tT-2\nBergen\tT-2\n(\tT-2\nNorway\tT-2\n)\tT-2\n\nCup\tO\nWinners\tO\n'\tO\nCup\tO\nx-Cercle\tB-ORG\nBrugge\tI-ORG\n(\tO\nBelgium\tT-0\n)\tO\nv\tO\nBrann\tO\nBergen\tO\n(\tO\nNorway\tT-1\n)\tO\n\nCup\tT-1\nWinners\tO\n'\tO\nCup\tO\nx-Cercle\tO\nBrugge\tT-0\n(\tO\nBelgium\tB-LOC\n)\tO\nv\tO\nBrann\tO\nBergen\tO\n(\tO\nNorway\tO\n)\tT-0\n\nCup\tT-0\nWinners\tT-0\n'\tO\nCup\tO\nx-Cercle\tO\nBrugge\tO\n(\tO\nBelgium\tO\n)\tO\nv\tO\nBrann\tB-ORG\nBergen\tI-ORG\n(\tO\nNorway\tO\n)\tO\n\nCup\tO\nWinners\tO\n'\tO\nCup\tO\nx-Cercle\tT-0\nBrugge\tT-0\n(\tO\nBelgium\tO\n)\tO\nv\tO\nBrann\tO\nBergen\tO\n(\tO\nNorway\tB-LOC\n)\tO\n\nCRICKET\tT-1\n-\tO\nSRI\tB-LOC\nLANKA\tI-LOC\nAND\tT-0\nAUSTRALIA\tT-0\nSAY\tO\nRELATIONS\tO\nHAVE\tO\nHEALED\tO\n.\tO\n\nCRICKET\tO\n-\tO\nSRI\tO\nLANKA\tO\nAND\tO\nAUSTRALIA\tB-LOC\nSAY\tO\nRELATIONS\tT-0\nHAVE\tO\nHEALED\tO\n.\tO\n\nSri\tB-LOC\nLanka\tI-LOC\nand\tT-1\nAustralia\tT-1\nagreed\tT-1\non\tT-1\nFriday\tT-1\nthat\tO\nrelations\tO\nbetween\tO\nthe\tO\ntwo\tO\nteams\tO\nhad\tO\nhealed\tO\nsince\tO\nthe\tO\nSri\tO\nLankans\tO\n'\tO\nacrimonious\tT-0\ntour\tO\nlast\tO\nyear\tO\n.\tO\n\nSri\tT-0\nLanka\tT-0\nand\tT-0\nAustralia\tB-LOC\nagreed\tO\non\tO\nFriday\tO\nthat\tO\nrelations\tO\nbetween\tO\nthe\tO\ntwo\tO\nteams\tT-1\nhad\tO\nhealed\tO\nsince\tO\nthe\tO\nSri\tO\nLankans\tO\n'\tO\nacrimonious\tO\ntour\tO\nlast\tO\nyear\tO\n.\tO\n\nSri\tO\nLanka\tO\nand\tO\nAustralia\tO\nagreed\tO\non\tO\nFriday\tO\nthat\tO\nrelations\tO\nbetween\tO\nthe\tO\ntwo\tT-1\nteams\tT-1\nhad\tT-1\nhealed\tT-1\nsince\tT-3\nthe\tT-3\nSri\tB-MISC\nLankans\tI-MISC\n'\tO\nacrimonious\tT-2\ntour\tT-4\nlast\tT-4\nyear\tT-4\n.\tO\n\nThe\tO\nSri\tB-MISC\nLankans\tI-MISC\nwere\tO\nfirst\tO\nfound\tT-1\nguilty\tT-0\nthen\tO\ncleared\tO\nof\tO\nball\tO\ntampering\tO\nand\tO\noff-spinner\tO\nMuttiah\tO\nMuralitharan\tO\nwas\tO\ncalled\tO\nfor\tO\nthrowing\tO\nduring\tO\na\tO\ncontroversial\tO\nthree-test\tO\nseries\tO\nin\tO\nAustralia\tO\n.\tO\n\nThe\tO\nSri\tO\nLankans\tO\nwere\tO\nfirst\tO\nfound\tO\nguilty\tO\nthen\tO\ncleared\tO\nof\tO\nball\tO\ntampering\tT-0\nand\tO\noff-spinner\tO\nMuttiah\tB-PER\nMuralitharan\tI-PER\nwas\tO\ncalled\tT-1\nfor\tO\nthrowing\tT-2\nduring\tO\na\tO\ncontroversial\tO\nthree-test\tO\nseries\tO\nin\tO\nAustralia\tO\n.\tO\n\nThe\tO\nSri\tT-0\nLankans\tT-0\nwere\tO\nfirst\tO\nfound\tO\nguilty\tT-1\nthen\tO\ncleared\tO\nof\tO\nball\tO\ntampering\tO\nand\tO\noff-spinner\tO\nMuttiah\tT-2\nMuralitharan\tT-2\nwas\tT-3\ncalled\tT-3\nfor\tO\nthrowing\tO\nduring\tO\na\tO\ncontroversial\tO\nthree-test\tO\nseries\tO\nin\tT-4\nAustralia\tB-LOC\n.\tO\n\n\"\tO\nOur\tO\nconcern\tT-2\nis\tO\nto\tO\nget\tO\nout\tT-3\nthere\tT-3\nand\tO\nplay\tO\nproper\tO\ncricket\tT-0\n,\tO\n\"\tO\nSri\tB-LOC\nLanka\tI-LOC\ncaptain\tO\nArjuna\tO\nRanatunga\tO\ntold\tO\na\tO\nnews\tO\nconference\tO\non\tO\nthe\tO\neve\tO\nof\tO\na\tO\nwarmup\tO\nmatch\tT-1\nbetween\tO\nthe\tO\nWorld\tO\nCup\tO\nchampions\tO\nand\tO\na\tO\nWorld\tO\nXI\tO\nteam\tO\nscheduled\tO\nfor\tO\nSaturday\tO\n.\tO\n\n\"\tO\nOur\tO\nconcern\tO\nis\tO\nto\tO\nget\tO\nout\tO\nthere\tO\nand\tO\nplay\tO\nproper\tO\ncricket\tO\n,\tO\n\"\tO\nSri\tT-1\nLanka\tT-1\ncaptain\tT-1\nArjuna\tB-PER\nRanatunga\tI-PER\ntold\tO\na\tO\nnews\tO\nconference\tT-0\non\tO\nthe\tO\neve\tO\nof\tO\na\tO\nwarmup\tO\nmatch\tO\nbetween\tO\nthe\tO\nWorld\tO\nCup\tO\nchampions\tO\nand\tO\na\tO\nWorld\tO\nXI\tO\nteam\tO\nscheduled\tO\nfor\tO\nSaturday\tO\n.\tO\n\n\"\tO\nOur\tO\nconcern\tO\nis\tO\nto\tO\nget\tO\nout\tO\nthere\tO\nand\tO\nplay\tO\nproper\tO\ncricket\tO\n,\tO\n\"\tO\nSri\tO\nLanka\tO\ncaptain\tO\nArjuna\tT-1\nRanatunga\tT-1\ntold\tO\na\tO\nnews\tO\nconference\tO\non\tO\nthe\tO\neve\tO\nof\tO\na\tO\nwarmup\tO\nmatch\tO\nbetween\tO\nthe\tO\nWorld\tB-MISC\nCup\tI-MISC\nchampions\tT-0\nand\tO\na\tO\nWorld\tO\nXI\tO\nteam\tO\nscheduled\tO\nfor\tO\nSaturday\tO\n.\tO\n\n\"\tO\nOur\tO\nconcern\tT-1\nis\tO\nto\tO\nget\tO\nout\tO\nthere\tO\nand\tO\nplay\tO\nproper\tO\ncricket\tO\n,\tO\n\"\tO\nSri\tO\nLanka\tO\ncaptain\tO\nArjuna\tO\nRanatunga\tO\ntold\tO\na\tO\nnews\tO\nconference\tO\non\tO\nthe\tO\neve\tO\nof\tO\na\tO\nwarmup\tO\nmatch\tO\nbetween\tO\nthe\tO\nWorld\tO\nCup\tO\nchampions\tO\nand\tO\na\tT-0\nWorld\tB-ORG\nXI\tI-ORG\nteam\tO\nscheduled\tO\nfor\tO\nSaturday\tO\n.\tO\n\nAustralian\tB-MISC\nteam\tT-0\nmanager\tT-0\nCam\tT-1\nBattersby\tT-1\nsaid\tO\nhe\tO\nagreed\tO\nwith\tO\nRanatunga\tT-2\n.\tO\n\nAustralian\tO\nteam\tO\nmanager\tT-0\nCam\tB-PER\nBattersby\tI-PER\nsaid\tT-1\nhe\tO\nagreed\tO\nwith\tO\nRanatunga\tT-2\n.\tO\n\nAustralian\tT-0\nteam\tO\nmanager\tO\nCam\tO\nBattersby\tO\nsaid\tO\nhe\tO\nagreed\tT-1\nwith\tO\nRanatunga\tB-PER\n.\tO\n\n\"\tO\nI\tT-0\nbelieve\tO\nrelations\tT-1\nbetween\tO\nthe\tO\ntwo\tO\nteams\tO\nwill\tO\nbe\tO\nexcellent\tT-2\n,\tO\n\"\tO\nBatterby\tB-PER\nsaid\tO\n.\tO\n\nThe\tT-1\nAustralians\tB-MISC\nare\tO\nmaking\tO\ntheir\tT-2\nfirst\tO\nvisit\tT-0\nto\tO\nthe\tO\nIndian\tO\nOcean\tO\nisland\tO\nsince\tO\nboycotting\tO\na\tO\nWorld\tT-3\nCup\tT-3\nfixture\tO\nin\tO\nFebruary\tO\nafter\tO\na\tO\nterrorist\tO\nbomb\tO\nin\tO\nColombo\tO\n.\tO\n\nThe\tO\nAustralians\tT-0\nare\tO\nmaking\tO\ntheir\tO\nfirst\tO\nvisit\tT-1\nto\tO\nthe\tO\nIndian\tB-LOC\nOcean\tI-LOC\nisland\tT-3\nsince\tO\nboycotting\tO\na\tO\nWorld\tT-2\nCup\tT-2\nfixture\tO\nin\tO\nFebruary\tO\nafter\tO\na\tO\nterrorist\tO\nbomb\tO\nin\tO\nColombo\tO\n.\tO\n\nThe\tO\nAustralians\tT-1\nare\tO\nmaking\tO\ntheir\tO\nfirst\tO\nvisit\tT-0\nto\tO\nthe\tO\nIndian\tT-2\nOcean\tT-2\nisland\tT-3\nsince\tO\nboycotting\tO\na\tO\nWorld\tB-MISC\nCup\tI-MISC\nfixture\tO\nin\tO\nFebruary\tO\nafter\tO\na\tO\nterrorist\tO\nbomb\tO\nin\tO\nColombo\tT-4\n.\tO\n\nThe\tO\nAustralians\tO\nare\tO\nmaking\tO\ntheir\tO\nfirst\tO\nvisit\tO\nto\tO\nthe\tO\nIndian\tO\nOcean\tO\nisland\tO\nsince\tO\nboycotting\tO\na\tO\nWorld\tO\nCup\tO\nfixture\tO\nin\tO\nFebruary\tO\nafter\tO\na\tO\nterrorist\tT-0\nbomb\tT-0\nin\tT-0\nColombo\tB-LOC\n.\tO\n\nAustralia\tB-LOC\nhave\tT-0\nbeen\tT-0\npromised\tO\nthe\tO\npresence\tT-1\nof\tO\ncommandos\tO\n,\tO\nsniffer\tO\ndogs\tO\nand\tO\nplainclothes\tO\npolicemen\tO\nto\tO\nensure\tT-2\na\tO\nlimited\tO\novers\tO\ntournament\tO\nis\tO\ntrouble-free\tO\n.\tO\n\nThe\tO\ntournament\tO\n,\tO\nstarting\tO\non\tO\nAugust\tO\n26\tO\n,\tO\nalso\tO\nincludes\tT-0\nIndia\tB-LOC\nand\tO\nZimbabwe\tO\n.\tO\n\nThe\tO\ntournament\tT-1\n,\tO\nstarting\tO\non\tO\nAugust\tO\n26\tO\n,\tO\nalso\tO\nincludes\tT-0\nIndia\tO\nand\tO\nZimbabwe\tB-LOC\n.\tO\n\nBattersby\tB-PER\nsaid\tT-1\nhe\tT-2\nwas\tO\nsatisfied\tO\nwith\tO\nthe\tO\nsecurity\tT-3\narrangements\tT-0\n.\tO\n\nSri\tB-MISC\nLankan\tI-MISC\nofficials\tT-1\nsaid\tT-2\nthey\tO\nexpected\tO\nheavy\tT-3\nrain\tT-3\nwhich\tO\nwashed\tO\nout\tO\na\tO\nwarmup\tO\nmatch\tT-0\non\tO\nFriday\tO\nshould\tO\ncease\tO\nby\tO\nSaturday\tO\n.\tO\n\nAustralia\tB-LOC\n,\tO\nled\tT-0\nby\tT-0\nwicketkeeper\tT-0\nIan\tT-0\nHealy\tT-0\n,\tO\nopened\tO\ntheir\tO\nshort\tO\ntour\tO\nof\tO\nSri\tT-1\nLanka\tT-1\nwith\tO\na\tO\nfive-run\tO\nwin\tO\nover\tO\nthe\tO\ncountry\tO\n's\tO\nyouth\tO\nteam\tT-2\non\tO\nThursday\tO\n.\tO\n\nAustralia\tT-0\n,\tO\nled\tO\nby\tO\nwicketkeeper\tT-2\nIan\tB-PER\nHealy\tI-PER\n,\tO\nopened\tT-1\ntheir\tO\nshort\tO\ntour\tO\nof\tO\nSri\tO\nLanka\tO\nwith\tO\na\tO\nfive-run\tO\nwin\tO\nover\tO\nthe\tO\ncountry\tO\n's\tO\nyouth\tO\nteam\tO\non\tO\nThursday\tO\n.\tO\n\nAustralia\tT-0\n,\tO\nled\tO\nby\tO\nwicketkeeper\tO\nIan\tT-1\nHealy\tT-1\n,\tO\nopened\tO\ntheir\tO\nshort\tO\ntour\tO\nof\tT-2\nSri\tB-LOC\nLanka\tI-LOC\nwith\tO\na\tO\nfive-run\tO\nwin\tO\nover\tO\nthe\tO\ncountry\tO\n's\tO\nyouth\tO\nteam\tO\non\tO\nThursday\tO\n.\tO\n\nReuters\tB-ORG\nhas\tO\nnot\tO\nverified\tT-0\nthese\tO\nstories\tO\nand\tO\ndoes\tO\nnot\tO\nvouch\tO\nfor\tO\ntheir\tO\naccuracy\tO\n.\tO\n\n-\tO\nThe\tT-0\nAngolan\tB-MISC\nChief\tT-1\nof\tT-1\nState\tT-1\naddressed\tO\na\tO\nletter\tO\nto\tO\nUN\tT-2\nSecurity\tT-2\nCouncil\tT-2\nproposing\tO\ndates\tO\nfor\tO\nthe\tO\nconclusion\tO\nof\tO\nthe\tO\npeace\tO\nprocess\tO\nin\tO\nAngola\tT-3\n.\tO\n\n-\tO\nThe\tO\nAngolan\tT-0\nChief\tO\nof\tO\nState\tO\naddressed\tO\na\tT-1\nletter\tT-1\nto\tT-1\nUN\tB-ORG\nSecurity\tI-ORG\nCouncil\tI-ORG\nproposing\tT-2\ndates\tT-2\nfor\tO\nthe\tO\nconclusion\tO\nof\tO\nthe\tO\npeace\tO\nprocess\tO\nin\tO\nAngola\tO\n.\tO\n\n-\tO\nThe\tO\nAngolan\tT-1\nChief\tT-1\nof\tO\nState\tO\naddressed\tO\na\tO\nletter\tO\nto\tO\nUN\tO\nSecurity\tO\nCouncil\tO\nproposing\tO\ndates\tO\nfor\tO\nthe\tO\nconclusion\tO\nof\tO\nthe\tO\npeace\tO\nprocess\tO\nin\tT-0\nAngola\tB-LOC\n.\tO\n\nHe\tO\nproposed\tT-0\ndefinite\tO\ndates\tO\n,\tO\nAugust\tO\n25\tO\nfor\tO\nreturn\tO\nof\tO\nUnita\tB-ORG\ngenerals\tT-1\nto\tO\nthe\tO\njoint\tO\narmy\tO\n,\tO\nSeptember\tO\n5\tO\nfor\tO\nthe\tO\nbeginning\tO\nof\tO\nthe\tO\nformation\tT-2\nof\tO\nthe\tO\nGovernment\tO\nof\tO\nNational\tO\nUnity\tO\nand\tO\nReconciliation\tT-3\n.\tO\n\nHe\tO\nproposed\tT-2\ndefinite\tO\ndates\tO\n,\tO\nAugust\tO\n25\tO\nfor\tO\nreturn\tO\nof\tO\nUnita\tO\ngenerals\tO\nto\tO\nthe\tO\njoint\tO\narmy\tT-1\n,\tO\nSeptember\tO\n5\tO\nfor\tO\nthe\tO\nbeginning\tT-0\nof\tO\nthe\tO\nformation\tO\nof\tO\nthe\tO\nGovernment\tB-ORG\nof\tI-ORG\nNational\tI-ORG\nUnity\tI-ORG\nand\tI-ORG\nReconciliation\tI-ORG\n.\tO\n\nUntil\tO\nthis\tO\ndate\tO\nthe\tO\nfree\tO\ncirculation\tO\nof\tO\npeoples\tO\nand\tO\ngoods\tO\nshould\tO\nbe\tO\nguaranteed\tO\n,\tO\nthe\tO\ngovernment\tT-0\nadministration\tO\ninstalled\tO\nin\tO\nall\tO\nareas\tO\nand\tO\nthe\tO\nUnita\tB-ORG\ndeputies\tO\nshould\tO\noccupy\tO\ntheir\tO\nplaces\tO\nin\tO\nthe\tO\nNational\tT-1\nAssembly\tO\n.\tO\n\nUntil\tO\nthis\tO\ndate\tO\nthe\tO\nfree\tO\ncirculation\tO\nof\tO\npeoples\tO\nand\tO\ngoods\tO\nshould\tO\nbe\tO\nguaranteed\tO\n,\tO\nthe\tO\ngovernment\tO\nadministration\tT-1\ninstalled\tO\nin\tO\nall\tO\nareas\tO\nand\tO\nthe\tO\nUnita\tT-2\ndeputies\tO\nshould\tO\noccupy\tT-3\ntheir\tO\nplaces\tT-0\nin\tO\nthe\tO\nNational\tB-ORG\nAssembly\tI-ORG\n.\tO\n\nThe\tO\npresident\tO\njustified\tT-0\nhis\tO\nproposal\tT-2\nby\tO\nthe\tO\ndelays\tO\nverified\tT-1\nin\tT-1\nthe\tO\npeace\tO\nprocess\tO\n,\tO\nincluding\tO\nthe\tO\nfact\tO\nthat\tO\nareas\tO\nunder\tO\nUnita\tB-ORG\ncontrol\tO\nor\tO\noccupation\tO\nhave\tO\nnot\tO\nbeen\tO\neffectively\tO\ndemilitarised\tO\n,\tO\nwhere\tO\nthe\tO\nUnita\tO\nmilitary\tO\nforces\tO\nhave\tO\nbeen\tO\nsubstituted\tO\nby\tO\ntheir\tO\nso-called\tO\npolice\tO\n.\tO\n\nThe\tO\npresident\tO\njustified\tO\nhis\tO\nproposal\tO\nby\tO\nthe\tO\ndelays\tT-0\nverified\tO\nin\tO\nthe\tO\npeace\tO\nprocess\tO\n,\tO\nincluding\tO\nthe\tO\nfact\tO\nthat\tO\nareas\tO\nunder\tO\nUnita\tO\ncontrol\tO\nor\tO\noccupation\tO\nhave\tO\nnot\tO\nbeen\tO\neffectively\tO\ndemilitarised\tO\n,\tO\nwhere\tO\nthe\tO\nUnita\tB-ORG\nmilitary\tO\nforces\tO\nhave\tO\nbeen\tO\nsubstituted\tO\nby\tO\ntheir\tO\nso-called\tO\npolice\tO\n.\tO\n\n-\tO\nPresident\tT-0\nDos\tB-PER\nSantos\tI-PER\nproposes\tO\nthe\tO\nestablishment\tO\nby\tO\nUN\tO\nSecurity\tO\nCouncil\tO\nof\tO\ndefinitive\tO\nand\tO\nfinal\tO\ntimetable\tO\nfor\tO\nthe\tO\ntasks\tO\nand\tO\nobligations\tO\nunder\tO\nthe\tO\nLusaka\tO\nAgreement\tO\nand\tO\nthe\tO\nsending\tO\nof\tO\na\tO\nmission\tO\nof\tO\nSC\tO\n,\tO\nas\tO\nsoon\tO\nas\tO\npossible\tO\n,\tO\nto\tO\nsupervise\tO\nthe\tO\nexecution\tO\nof\tO\nthe\tO\nagreement\tO\n.\tO\n\n-\tO\nPresident\tT-1\nDos\tT-1\nSantos\tT-1\nproposes\tO\nthe\tO\nestablishment\tT-0\nby\tT-0\nUN\tB-ORG\nSecurity\tI-ORG\nCouncil\tI-ORG\nof\tO\ndefinitive\tO\nand\tO\nfinal\tO\ntimetable\tO\nfor\tO\nthe\tO\ntasks\tO\nand\tO\nobligations\tO\nunder\tO\nthe\tO\nLusaka\tO\nAgreement\tO\nand\tO\nthe\tO\nsending\tO\nof\tO\na\tO\nmission\tO\nof\tO\nSC\tT-2\n,\tO\nas\tO\nsoon\tO\nas\tO\npossible\tO\n,\tO\nto\tO\nsupervise\tO\nthe\tO\nexecution\tO\nof\tO\nthe\tO\nagreement\tO\n.\tO\n\n-\tO\nPresident\tO\nDos\tO\nSantos\tO\nproposes\tO\nthe\tO\nestablishment\tO\nby\tO\nUN\tO\nSecurity\tO\nCouncil\tO\nof\tO\ndefinitive\tO\nand\tO\nfinal\tO\ntimetable\tO\nfor\tO\nthe\tO\ntasks\tT-1\nand\tT-1\nobligations\tT-1\nunder\tT-1\nthe\tT-1\nLusaka\tB-MISC\nAgreement\tI-MISC\nand\tO\nthe\tO\nsending\tT-0\nof\tO\na\tO\nmission\tO\nof\tO\nSC\tO\n,\tO\nas\tO\nsoon\tO\nas\tO\npossible\tO\n,\tO\nto\tO\nsupervise\tO\nthe\tO\nexecution\tO\nof\tO\nthe\tO\nagreement\tO\n.\tO\n\n-\tO\nPresident\tT-1\nDos\tT-1\nSantos\tT-1\nproposes\tO\nthe\tO\nestablishment\tO\nby\tO\nUN\tO\nSecurity\tO\nCouncil\tO\nof\tO\ndefinitive\tO\nand\tO\nfinal\tO\ntimetable\tO\nfor\tO\nthe\tO\ntasks\tO\nand\tO\nobligations\tO\nunder\tO\nthe\tO\nLusaka\tO\nAgreement\tO\nand\tO\nthe\tO\nsending\tO\nof\tO\na\tO\nmission\tT-0\nof\tO\nSC\tB-ORG\n,\tO\nas\tO\nsoon\tO\nas\tO\npossible\tO\n,\tO\nto\tO\nsupervise\tO\nthe\tO\nexecution\tO\nof\tO\nthe\tO\nagreement\tO\n.\tO\n\nFORECAST\tT-0\n-\tO\nS.AFRICAN\tB-MISC\nCOMPANY\tT-2\nRESULTS\tO\nCONSENSUS\tT-1\n.\tO\n\nSouth\tB-MISC\nAfrican\tI-MISC\ncompany\tO\nresults\tT-0\nexpected\tO\nnext\tO\nweek\tO\ninclude\tO\nthe\tO\n\nMON\tT-0\nGencor\tB-ORG\nYR\tO\nEPS\tO\n93.12\tO\n92.0-94.5\tO\n73.8\tO\n\nMON\tO\nGencor\tB-ORG\nYR\tT-0\nDIV\tT-0\n25.75\tT-0\n25.0-27.0\tO\n20.0\tO\n\nMON\tT-0\nPrimedia\tB-ORG\nYR\tO\nEPS\tO\nN\tO\n/\tO\nA\tO\n149.1\tO\n\nMON\tT-0\nPrimedia\tB-ORG\nYR\tO\nDIV\tO\nN\tO\n/\tO\nA\tO\n123.2\tO\n\nMON\tT-0\nDistillers\tB-ORG\nYR\tO\nEPS\tT-1\nN\tT-1\n/\tO\nA\tO\n71.8\tO\n\nTUE\tT-1\nIscor\tB-ORG\nYR\tO\nEPS\tO\n29.7\tT-0\n26.0-32.0\tT-0\n38.0\tT-0\n\nTUE\tO\nIscor\tB-ORG\nYR\tT-0\nDIV\tT-0\n15.0\tO\n14.5-16.5\tO\n16.5\tO\n\nWED\tT-0\nImphold\tB-ORG\nYR\tO\nEPS\tT-1\n172.7\tO\n170.4-175.0\tO\n115.1\tO\n\nWED\tT-0\nImphold\tB-ORG\nYR\tT-1\nDIV\tT-1\n67.5\tO\n66.6-68.4\tO\n45.0\tO\n\nTHU\tO\nM&R\tB-ORG\nYR\tT-0\nDIV\tT-0\n31.7\tO\n10.5-42.3\tO\n47.0\tO\n\nTHU\tT-0\nJD\tB-ORG\nGroup\tI-ORG\nYR\tT-1\nDIV\tT-1\n41.8\tO\n41.0-42.5\tO\n33.0\tO\n\n--\tO\nJohannesburg\tB-LOC\nnewsroom\tT-0\n,\tO\n+27\tO\n11\tO\n482\tO\n1003\tO\n\nUlster\tB-ORG\nPetroleums\tI-ORG\nLtd\tI-ORG\nQ2\tO\nnet\tO\nprofit\tT-0\nfalls\tO\n.\tO\n\nShr\tT-0\nC$\tB-MISC\n0.12\tO\nC$\tO\n0.15\tO\n\nNigerian\tB-MISC\nterms\tT-3\njeopardize\tT-0\nCommonwealth\tT-2\ntrip-Canada\tT-4\n.\tT-1\n\nNigerian\tT-1\nterms\tO\njeopardize\tT-0\nCommonwealth\tB-ORG\ntrip-Canada\tT-2\n.\tO\n\nNigerian\tO\nterms\tO\njeopardize\tT-0\nCommonwealth\tO\ntrip-Canada\tB-MISC\n.\tO\n\nCommonwealth\tB-ORG\nministers\tO\nconcerned\tT-0\nabout\tO\nhuman\tO\nrights\tO\nin\tO\nNigeria\tO\nmay\tO\ncancel\tO\na\tO\nplanned\tO\ntrip\tO\nthere\tO\nbecause\tO\nof\tO\ngovernment\tO\nrestrictions\tO\non\tO\ntheir\tT-3\nmission\tT-3\n,\tO\nCanadian\tT-1\nForeign\tT-1\nMinister\tT-1\nLloyd\tO\nAxworthy\tT-2\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nCommonwealth\tO\nministers\tO\nconcerned\tO\nabout\tO\nhuman\tO\nrights\tO\nin\tO\nNigeria\tB-LOC\nmay\tO\ncancel\tO\na\tO\nplanned\tT-1\ntrip\tT-1\nthere\tO\nbecause\tO\nof\tO\ngovernment\tO\nrestrictions\tO\non\tO\ntheir\tO\nmission\tO\n,\tO\nCanadian\tT-0\nForeign\tO\nMinister\tO\nLloyd\tO\nAxworthy\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nCommonwealth\tO\nministers\tT-1\nconcerned\tT-0\nabout\tO\nhuman\tO\nrights\tO\nin\tO\nNigeria\tO\nmay\tO\ncancel\tO\na\tO\nplanned\tO\ntrip\tT-3\nthere\tO\nbecause\tO\nof\tO\ngovernment\tO\nrestrictions\tO\non\tO\ntheir\tO\nmission\tT-2\n,\tO\nCanadian\tB-MISC\nForeign\tT-4\nMinister\tT-4\nLloyd\tT-4\nAxworthy\tT-4\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nCommonwealth\tO\nministers\tO\nconcerned\tO\nabout\tO\nhuman\tO\nrights\tO\nin\tO\nNigeria\tO\nmay\tO\ncancel\tT-0\na\tO\nplanned\tO\ntrip\tT-2\nthere\tO\nbecause\tO\nof\tO\ngovernment\tO\nrestrictions\tT-1\non\tO\ntheir\tO\nmission\tO\n,\tO\nCanadian\tO\nForeign\tO\nMinister\tO\nLloyd\tB-PER\nAxworthy\tI-PER\nsaid\tT-3\non\tO\nFriday\tO\n.\tO\n\n\"\tO\nThe\tO\nreaction\tO\nof\tO\nthe\tO\nregime\tT-1\nthere\tO\nis\tO\nsuch\tO\nthat\tO\nmany\tO\nof\tO\nus\tO\nfeel\tO\nthat\tO\nthe\tO\nmission\tO\nunder\tO\nthe\tO\npresent\tO\ncircumstances\tO\nshould\tO\nn't\tO\ngo\tO\nahead\tO\n,\tO\n\"\tO\nAxworthy\tB-PER\nsaid\tT-2\n.\tO\n\nCommonwealth\tB-ORG\nforeign\tT-0\nministers\tO\nwill\tO\nmeet\tT-1\nin\tO\nLondon\tO\non\tO\nWednesday\tO\nto\tO\ndiscuss\tO\nwhat\tO\nto\tO\ndo\tO\n,\tO\nhe\tO\nadded\tO\n.\tO\n\nCommonwealth\tO\nforeign\tO\nministers\tO\nwill\tO\nmeet\tT-0\nin\tO\nLondon\tB-LOC\non\tO\nWednesday\tO\nto\tO\ndiscuss\tO\nwhat\tO\nto\tO\ndo\tO\n,\tO\nhe\tO\nadded\tO\n.\tO\n\nInvestors\tO\ngave\tT-0\ninto\tO\ngold\tO\nfever\tO\nFriday\tO\nmorning\tO\n,\tO\nwith\tO\nheavy\tT-1\ntrading\tT-1\nin\tO\na\tO\nhandful\tT-2\nof\tT-2\nToronto-based\tB-MISC\ngold\tT-3\ncompanies\tT-3\n.\tO\n\nTVX\tB-ORG\nGold\tI-ORG\nInc\tI-ORG\nwas\tO\nup\tO\nC$\tO\n0.30\tO\nto\tO\nC$\tO\n11.55\tO\nin\tO\ntrading\tT-0\nof\tO\n780,000\tO\nshares\tO\n,\tO\nwhile\tO\nKinross\tT-1\nGold\tT-1\nCorp\tT-1\ngained\tO\nC$\tO\n0.25\tO\nto\tO\nC$\tO\n11\tO\nin\tO\nvolume\tO\nof\tO\n720,000\tO\nshares\tO\n.\tO\n\nTVX\tT-2\nGold\tT-2\nInc\tT-2\nwas\tO\nup\tO\nC$\tB-MISC\n0.30\tO\nto\tO\nC$\tO\n11.55\tO\nin\tO\ntrading\tO\nof\tO\n780,000\tO\nshares\tO\n,\tO\nwhile\tO\nKinross\tT-0\nGold\tO\nCorp\tO\ngained\tT-1\nC$\tO\n0.25\tO\nto\tO\nC$\tO\n11\tO\nin\tO\nvolume\tO\nof\tO\n720,000\tO\nshares\tO\n.\tO\n\nTVX\tO\nGold\tO\nInc\tO\nwas\tO\nup\tO\nC$\tO\n0.30\tO\nto\tT-0\nC$\tB-MISC\n11.55\tO\nin\tO\ntrading\tO\nof\tO\n780,000\tO\nshares\tO\n,\tO\nwhile\tO\nKinross\tO\nGold\tO\nCorp\tO\ngained\tO\nC$\tO\n0.25\tO\nto\tO\nC$\tO\n11\tO\nin\tO\nvolume\tT-1\nof\tO\n720,000\tO\nshares\tO\n.\tO\n\nTVX\tT-1\nGold\tT-1\nInc\tT-1\nwas\tO\nup\tO\nC$\tO\n0.30\tO\nto\tO\nC$\tO\n11.55\tO\nin\tO\ntrading\tT-0\nof\tO\n780,000\tO\nshares\tO\n,\tO\nwhile\tO\nKinross\tB-ORG\nGold\tI-ORG\nCorp\tI-ORG\ngained\tT-2\nC$\tO\n0.25\tO\nto\tO\nC$\tO\n11\tO\nin\tO\nvolume\tT-3\nof\tO\n720,000\tO\nshares\tO\n.\tO\n\nTVX\tO\nGold\tO\nInc\tO\nwas\tO\nup\tO\nC$\tO\n0.30\tO\nto\tO\nC$\tO\n11.55\tO\nin\tO\ntrading\tO\nof\tO\n780,000\tO\nshares\tO\n,\tO\nwhile\tO\nKinross\tT-0\nGold\tT-0\nCorp\tT-0\ngained\tT-0\nC$\tB-MISC\n0.25\tO\nto\tO\nC$\tO\n11\tO\nin\tO\nvolume\tO\nof\tO\n720,000\tO\nshares\tO\n.\tO\n\nTVX\tO\nGold\tO\nInc\tO\nwas\tO\nup\tO\nC$\tO\n0.30\tO\nto\tO\nC$\tO\n11.55\tO\nin\tO\ntrading\tO\nof\tO\n780,000\tO\nshares\tO\n,\tO\nwhile\tO\nKinross\tO\nGold\tO\nCorp\tO\ngained\tT-0\nC$\tO\n0.25\tO\nto\tO\nC$\tB-MISC\n11\tO\nin\tO\nvolume\tT-1\nof\tO\n720,000\tO\nshares\tO\n.\tO\n\nAnd\tO\nScorpion\tB-ORG\nMinerals\tI-ORG\nInc\tI-ORG\n,\tO\na\tO\njunior\tO\ngold\tO\nexploration\tO\ncompany\tT-2\nwith\tO\nfive\tO\nIndonesian\tT-0\nmining\tO\nproperties\tO\n,\tO\nwas\tO\nup\tT-1\nC$\tO\n0.50\tO\nto\tO\nC$\tO\n6\tO\n,\tO\nwith\tO\nabout\tO\n120,000\tO\nshares\tO\nchanging\tO\nhands\tO\n.\tO\n\nAnd\tO\nScorpion\tO\nMinerals\tO\nInc\tO\n,\tO\na\tO\njunior\tO\ngold\tO\nexploration\tO\ncompany\tO\nwith\tO\nfive\tO\nIndonesian\tB-MISC\nmining\tT-0\nproperties\tT-1\n,\tO\nwas\tO\nup\tO\nC$\tO\n0.50\tO\nto\tO\nC$\tO\n6\tO\n,\tO\nwith\tO\nabout\tO\n120,000\tO\nshares\tO\nchanging\tO\nhands\tO\n.\tO\n\nAnd\tO\nScorpion\tT-1\nMinerals\tT-1\nInc\tT-1\n,\tO\na\tO\njunior\tO\ngold\tO\nexploration\tO\ncompany\tO\nwith\tO\nfive\tO\nIndonesian\tO\nmining\tO\nproperties\tT-0\n,\tO\nwas\tO\nup\tO\nC$\tB-MISC\n0.50\tO\nto\tO\nC$\tO\n6\tO\n,\tO\nwith\tO\nabout\tO\n120,000\tO\nshares\tO\nchanging\tO\nhands\tO\n.\tO\n\nAnd\tO\nScorpion\tT-2\nMinerals\tO\nInc\tO\n,\tO\na\tO\njunior\tO\ngold\tO\nexploration\tO\ncompany\tO\nwith\tO\nfive\tO\nIndonesian\tT-3\nmining\tO\nproperties\tO\n,\tO\nwas\tO\nup\tO\nC$\tO\n0.50\tO\nto\tO\nC$\tB-MISC\n6\tT-1\n,\tO\nwith\tO\nabout\tO\n120,000\tO\nshares\tO\nchanging\tT-0\nhands\tO\n.\tO\n\nTVX\tB-ORG\nand\tO\nKinross\tO\nrose\tT-2\nafter\tO\nrecent\tO\nbuy\tO\nrecommendations\tT-0\nfrom\tO\nU.S.\tO\nbrokers\tO\n,\tO\nanalysts\tO\nsaid\tT-1\n.\tO\n\nTVX\tO\nand\tO\nKinross\tB-ORG\nrose\tO\nafter\tO\nrecent\tO\nbuy\tT-0\nrecommendations\tT-1\nfrom\tO\nU.S.\tO\nbrokers\tO\n,\tO\nanalysts\tO\nsaid\tT-2\n.\tO\n\nTVX\tO\nand\tO\nKinross\tO\nrose\tO\nafter\tO\nrecent\tO\nbuy\tO\nrecommendations\tO\nfrom\tT-0\nU.S.\tB-LOC\nbrokers\tT-1\n,\tO\nanalysts\tO\nsaid\tT-2\n.\tO\n\nBut\tO\nScorpion\tB-ORG\nwas\tO\nraising\tT-0\na\tO\nlot\tO\nof\tO\neyebrows\tO\nafter\tO\nit\tO\nissued\tT-1\na\tO\nrelease\tO\nFriday\tO\nmorning\tO\nsaying\tO\nit\tO\nwas\tO\nnot\tO\naware\tO\nof\tO\nany\tO\ndevelopments\tO\nthat\tO\ncould\tO\nhave\tO\naffected\tO\nthe\tO\nstock\tO\n.\tO\n\nRESEARCH\tT-0\nALERT\tO\n-\tO\nUnitog\tB-ORG\nCo\tI-ORG\nupgraded\tT-1\n.\tO\n\n-\tO\nBarrington\tB-ORG\nResearch\tI-ORG\nAssociates\tI-ORG\nInc\tI-ORG\nsaid\tO\nFriday\tO\nit\tO\nupgraded\tT-0\nUnitog\tT-0\nCo\tT-0\nto\tO\na\tO\nnear-term\tO\noutperform\tO\nfrom\tO\na\tO\nlong-term\tO\noutperform\tO\nrating\tO\n.\tO\n\n-\tO\nBarrington\tT-0\nResearch\tT-0\nAssociates\tT-0\nInc\tT-0\nsaid\tO\nFriday\tO\nit\tO\nupgraded\tO\nUnitog\tB-ORG\nCo\tI-ORG\nto\tO\na\tO\nnear-term\tO\noutperform\tT-1\nfrom\tO\na\tO\nlong-term\tO\noutperform\tO\nrating\tT-2\n.\tO\n\n-\tO\nAnalyst\tO\nAlexander\tB-PER\nParis\tI-PER\nsaid\tT-1\nhe\tO\nexpected\tT-0\nconsistent\tO\n20\tO\npercent\tO\nearnings\tO\ngrowth\tO\nafter\tO\nan\tO\nestimated\tO\ngain\tO\nof\tO\n18\tO\npercent\tO\nfor\tO\n1996\tO\n.\tO\n\n--\tO\nChicago\tB-LOC\nnewsdesk\tT-0\n,\tO\n312-408-8787\tO\n\nBuffett\tB-PER\nraises\tO\nProperty\tT-0\nCapital\tO\nstake\tT-1\n.\tO\n\nBuffett\tO\nraises\tT-0\nProperty\tB-ORG\nCapital\tI-ORG\nstake\tT-1\n.\tO\n\nOmaha\tB-LOC\nbillionaire\tT-3\nWarren\tO\nBuffett\tT-4\nsaid\tT-0\nFriday\tO\nhe\tO\nraised\tT-1\nhis\tO\nstake\tO\nin\tO\nProperty\tT-2\nCapital\tT-2\nTrust\tT-2\nto\tO\n8.0\tO\npercent\tO\nfrom\tO\n6.7\tO\npercent\tO\n.\tO\n\nOmaha\tO\nbillionaire\tT-0\nWarren\tB-PER\nBuffett\tI-PER\nsaid\tT-1\nFriday\tO\nhe\tO\nraised\tO\nhis\tO\nstake\tO\nin\tO\nProperty\tO\nCapital\tO\nTrust\tO\nto\tO\n8.0\tO\npercent\tO\nfrom\tO\n6.7\tO\npercent\tO\n.\tO\n\nOmaha\tO\nbillionaire\tO\nWarren\tO\nBuffett\tO\nsaid\tT-0\nFriday\tO\nhe\tO\nraised\tT-1\nhis\tO\nstake\tO\nin\tO\nProperty\tB-ORG\nCapital\tI-ORG\nTrust\tI-ORG\nto\tO\n8.0\tO\npercent\tT-2\nfrom\tO\n6.7\tO\npercent\tO\n.\tO\n\nIn\tO\na\tO\nfiling\tT-3\nwith\tT-3\nthe\tO\nSecurities\tB-ORG\nand\tI-ORG\nExchnage\tI-ORG\nCommission\tI-ORG\n,\tO\nBuffett\tT-0\nsaid\tT-1\nhe\tO\nbought\tO\n62,900\tO\nadditional\tO\ncommon\tO\nshares\tT-2\nof\tO\nthe\tO\nBoston-based\tO\nreal\tO\nestate\tO\ninvestment\tO\ntrust\tO\nat\tO\nprices\tO\nranging\tO\nfrom\tO\n$\tO\n7.65\tO\nto\tO\n$\tO\n8.02\tO\na\tO\nshare\tO\n.\tO\n\nIn\tO\na\tO\nfiling\tO\nwith\tO\nthe\tO\nSecurities\tT-2\nand\tT-2\nExchnage\tT-2\nCommission\tT-2\n,\tO\nBuffett\tB-PER\nsaid\tT-1\nhe\tO\nbought\tO\n62,900\tO\nadditional\tO\ncommon\tO\nshares\tO\nof\tO\nthe\tO\nBoston-based\tT-0\nreal\tO\nestate\tO\ninvestment\tO\ntrust\tO\nat\tO\nprices\tO\nranging\tO\nfrom\tO\n$\tO\n7.65\tO\nto\tO\n$\tO\n8.02\tO\na\tO\nshare\tO\n.\tT-0\n\nIn\tO\na\tO\nfiling\tO\nwith\tO\nthe\tO\nSecurities\tO\nand\tO\nExchnage\tT-3\nCommission\tO\n,\tO\nBuffett\tT-0\nsaid\tT-4\nhe\tO\nbought\tT-1\n62,900\tO\nadditional\tO\ncommon\tO\nshares\tO\nof\tO\nthe\tO\nBoston-based\tB-MISC\nreal\tT-2\nestate\tT-2\ninvestment\tT-2\ntrust\tT-2\nat\tO\nprices\tO\nranging\tO\nfrom\tO\n$\tO\n7.65\tO\nto\tO\n$\tO\n8.02\tO\na\tO\nshare\tO\n.\tO\n\nBuffett\tB-PER\n,\tO\nwho\tO\nis\tO\nwell-known\tO\nas\tO\na\tO\nlong-term\tO\ninvestor\tT-0\n,\tO\nis\tO\nchairman\tT-1\nof\tO\nBerkshire\tO\nHathaway\tO\nInc\tO\n,\tO\na\tO\nholding\tO\ncompany\tO\nthrough\tO\nwhich\tO\nhe\tO\nholds\tT-2\ninvestments\tO\nin\tO\nseveral\tO\nlarge\tO\nU.S.\tO\ncompanies\tO\n.\tO\n\nBuffett\tO\n,\tO\nwho\tO\nis\tO\nwell-known\tO\nas\tO\na\tO\nlong-term\tO\ninvestor\tO\n,\tO\nis\tO\nchairman\tT-0\nof\tT-0\nBerkshire\tB-ORG\nHathaway\tI-ORG\nInc\tI-ORG\n,\tO\na\tO\nholding\tT-1\ncompany\tO\nthrough\tO\nwhich\tO\nhe\tO\nholds\tO\ninvestments\tO\nin\tO\nseveral\tO\nlarge\tO\nU.S.\tO\ncompanies\tO\n.\tO\n\nBuffett\tO\n,\tO\nwho\tO\nis\tO\nwell-known\tO\nas\tO\na\tO\nlong-term\tO\ninvestor\tT-1\n,\tO\nis\tO\nchairman\tT-0\nof\tO\nBerkshire\tO\nHathaway\tO\nInc\tO\n,\tO\na\tO\nholding\tO\ncompany\tO\nthrough\tO\nwhich\tO\nhe\tO\nholds\tO\ninvestments\tO\nin\tO\nseveral\tO\nlarge\tO\nU.S.\tB-LOC\ncompanies\tT-2\n.\tO\n\nColombia\tB-LOC\n,\tO\nU.S.\tT-0\nreach\tT-1\naviation\tT-1\nagreement\tT-1\n.\tO\n\nColombia\tT-1\n,\tO\nU.S.\tB-LOC\nreach\tT-0\naviation\tT-0\nagreement\tT-2\n.\tT-2\n\nThe\tO\nU.S.\tB-LOC\nand\tO\nColombian\tO\ngovernments\tT-1\nreached\tO\nan\tO\nagreement\tO\nthat\tO\nwill\tO\nallow\tO\nAMR\tO\nCorp\tO\n's\tO\nAmerican\tO\nAirlines\tO\nto\tO\noperate\tO\nthree\tO\nround-trip\tO\nflights\tO\nbetween\tO\nNew\tO\nYork\tO\nand\tO\nBogota\tO\n,\tO\nthe\tO\nDepartment\tO\nof\tO\nTransportation\tO\nsaid\tT-0\nFriday\tO\n.\tO\n\nThe\tO\nU.S.\tO\nand\tO\nColombian\tB-MISC\ngovernments\tT-0\nreached\tT-1\nan\tT-1\nagreement\tT-1\nthat\tO\nwill\tO\nallow\tO\nAMR\tO\nCorp\tO\n's\tO\nAmerican\tO\nAirlines\tO\nto\tO\noperate\tO\nthree\tO\nround-trip\tO\nflights\tO\nbetween\tO\nNew\tO\nYork\tO\nand\tO\nBogota\tO\n,\tO\nthe\tO\nDepartment\tO\nof\tO\nTransportation\tO\nsaid\tO\nFriday\tO\n.\tO\n\nThe\tO\nU.S.\tT-2\nand\tO\nColombian\tT-3\ngovernments\tT-3\nreached\tO\nan\tO\nagreement\tT-0\nthat\tO\nwill\tO\nallow\tO\nAMR\tB-ORG\nCorp\tI-ORG\n's\tO\nAmerican\tT-5\nAirlines\tT-5\nto\tO\noperate\tT-1\nthree\tO\nround-trip\tO\nflights\tO\nbetween\tO\nNew\tT-6\nYork\tT-6\nand\tO\nBogota\tT-7\n,\tO\nthe\tO\nDepartment\tT-4\nof\tT-4\nTransportation\tT-4\nsaid\tO\nFriday\tO\n.\tO\n\nThe\tO\nU.S.\tO\nand\tO\nColombian\tO\ngovernments\tO\nreached\tT-0\nan\tO\nagreement\tT-1\nthat\tO\nwill\tO\nallow\tO\nAMR\tT-2\nCorp\tT-2\n's\tT-2\nAmerican\tB-ORG\nAirlines\tI-ORG\nto\tO\noperate\tT-3\nthree\tO\nround-trip\tO\nflights\tO\nbetween\tO\nNew\tO\nYork\tO\nand\tO\nBogota\tO\n,\tO\nthe\tO\nDepartment\tO\nof\tO\nTransportation\tO\nsaid\tO\nFriday\tO\n.\tO\n\nThe\tO\nU.S.\tT-0\nand\tT-0\nColombian\tT-0\ngovernments\tO\nreached\tO\nan\tO\nagreement\tT-2\nthat\tO\nwill\tO\nallow\tO\nAMR\tO\nCorp\tO\n's\tO\nAmerican\tT-4\nAirlines\tT-4\nto\tO\noperate\tO\nthree\tO\nround-trip\tT-1\nflights\tT-1\nbetween\tO\nNew\tB-LOC\nYork\tI-LOC\nand\tO\nBogota\tO\n,\tO\nthe\tO\nDepartment\tO\nof\tO\nTransportation\tO\nsaid\tT-3\nFriday\tO\n.\tO\n\nThe\tO\nU.S.\tO\nand\tO\nColombian\tT-2\ngovernments\tO\nreached\tO\nan\tO\nagreement\tT-0\nthat\tO\nwill\tO\nallow\tO\nAMR\tO\nCorp\tO\n's\tO\nAmerican\tO\nAirlines\tO\nto\tO\noperate\tO\nthree\tO\nround-trip\tO\nflights\tO\nbetween\tO\nNew\tO\nYork\tO\nand\tO\nBogota\tB-LOC\n,\tO\nthe\tO\nDepartment\tT-1\nof\tO\nTransportation\tO\nsaid\tO\nFriday\tO\n.\tO\n\nThe\tO\nU.S.\tO\nand\tO\nColombian\tT-0\ngovernments\tO\nreached\tT-2\nan\tO\nagreement\tO\nthat\tO\nwill\tO\nallow\tO\nAMR\tT-1\nCorp\tO\n's\tO\nAmerican\tO\nAirlines\tO\nto\tO\noperate\tO\nthree\tO\nround-trip\tO\nflights\tO\nbetween\tO\nNew\tO\nYork\tO\nand\tO\nBogota\tO\n,\tO\nthe\tO\nDepartment\tB-ORG\nof\tI-ORG\nTransportation\tI-ORG\nsaid\tT-3\nFriday\tO\n.\tO\n\nUnder\tO\nthe\tO\nagreement\tO\n,\tO\nwhich\tO\nfollowed\tO\ntalks\tO\nin\tT-0\nMiami\tB-LOC\nthis\tO\nweek\tO\n,\tO\nAMR\tO\nalso\tO\nwill\tO\nbe\tO\nallowed\tO\nto\tO\nshift\tO\nup\tO\nto\tO\nfour\tO\nof\tO\nthe\tO\nweekly\tO\nflights\tO\nit\tO\nnow\tO\noperates\tO\nbetween\tO\nMiami\tO\nand\tO\nColombia\tO\nto\tO\nits\tO\nNew\tO\nYork\tO\ngateway\tO\n.\tO\n\nUnder\tO\nthe\tO\nagreement\tT-1\n,\tO\nwhich\tO\nfollowed\tO\ntalks\tO\nin\tO\nMiami\tO\nthis\tO\nweek\tO\n,\tO\nAMR\tB-ORG\nalso\tO\nwill\tO\nbe\tO\nallowed\tT-0\nto\tO\nshift\tO\nup\tO\nto\tO\nfour\tO\nof\tO\nthe\tO\nweekly\tO\nflights\tO\nit\tO\nnow\tO\noperates\tO\nbetween\tO\nMiami\tO\nand\tO\nColombia\tO\nto\tO\nits\tO\nNew\tT-2\nYork\tT-2\ngateway\tO\n.\tO\n\nUnder\tO\nthe\tO\nagreement\tO\n,\tO\nwhich\tO\nfollowed\tO\ntalks\tO\nin\tO\nMiami\tT-1\nthis\tO\nweek\tO\n,\tO\nAMR\tO\nalso\tO\nwill\tO\nbe\tO\nallowed\tO\nto\tO\nshift\tO\nup\tO\nto\tO\nfour\tO\nof\tO\nthe\tO\nweekly\tO\nflights\tT-2\nit\tO\nnow\tO\noperates\tT-3\nbetween\tO\nMiami\tB-LOC\nand\tT-0\nColombia\tT-4\nto\tO\nits\tO\nNew\tO\nYork\tO\ngateway\tO\n.\tO\n\nUnder\tO\nthe\tO\nagreement\tT-0\n,\tO\nwhich\tO\nfollowed\tO\ntalks\tT-1\nin\tO\nMiami\tO\nthis\tO\nweek\tO\n,\tO\nAMR\tO\nalso\tO\nwill\tO\nbe\tO\nallowed\tO\nto\tO\nshift\tO\nup\tO\nto\tO\nfour\tO\nof\tO\nthe\tO\nweekly\tO\nflights\tO\nit\tO\nnow\tO\noperates\tT-2\nbetween\tO\nMiami\tT-3\nand\tO\nColombia\tB-LOC\nto\tO\nits\tO\nNew\tO\nYork\tO\ngateway\tO\n.\tO\n\nUnder\tO\nthe\tO\nagreement\tO\n,\tO\nwhich\tO\nfollowed\tO\ntalks\tO\nin\tO\nMiami\tO\nthis\tO\nweek\tO\n,\tO\nAMR\tO\nalso\tO\nwill\tO\nbe\tO\nallowed\tO\nto\tO\nshift\tO\nup\tO\nto\tO\nfour\tO\nof\tO\nthe\tO\nweekly\tO\nflights\tO\nit\tO\nnow\tO\noperates\tO\nbetween\tT-1\nMiami\tT-2\nand\tO\nColombia\tT-3\nto\tO\nits\tO\nNew\tB-LOC\nYork\tI-LOC\ngateway\tT-0\n.\tO\n\nThe\tO\nUnited\tB-LOC\nStates\tI-LOC\nalso\tO\nwill\tT-3\nbe\tT-3\nable\tT-3\nto\tT-3\ndesignate\tO\none\tO\nnew\tT-1\nall-cargo\tT-1\ncarrier\tT-1\nfor\tO\nservice\tO\nbetween\tO\nthe\tO\ntwo\tT-0\nnations\tT-0\nafter\tO\ntwo\tT-2\nyears\tT-2\n.\tO\n\nColombia\tB-LOC\nwas\tT-1\npermitted\tO\nto\tO\nadd\tO\na\tO\nsingle\tO\nadditional\tO\nround-trip\tO\nflight\tO\nto\tO\nits\tO\ncurrent\tO\nNew\tT-0\nYork\tT-0\nservice\tO\n,\tO\nalthough\tO\nit\tO\nwill\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\ndo\tO\nso\tO\nwhile\tO\nunder\tO\nCategory\tO\nTwo\tO\n(\tO\nConditional\tO\n)\tO\nstatus\tO\nunder\tO\nthe\tO\nFederal\tO\nAviation\tO\nAdministration\tO\n's\tO\nInternational\tO\nAviation\tO\nSafety\tO\nprogram\tO\n.\tO\n\nColombia\tT-1\nwas\tO\npermitted\tO\nto\tO\nadd\tO\na\tO\nsingle\tO\nadditional\tT-2\nround-trip\tT-2\nflight\tT-0\nto\tT-0\nits\tT-0\ncurrent\tO\nNew\tB-LOC\nYork\tI-LOC\nservice\tO\n,\tO\nalthough\tO\nit\tO\nwill\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\ndo\tO\nso\tO\nwhile\tO\nunder\tO\nCategory\tO\nTwo\tO\n(\tO\nConditional\tO\n)\tO\nstatus\tO\nunder\tO\nthe\tO\nFederal\tO\nAviation\tO\nAdministration\tO\n's\tO\nInternational\tO\nAviation\tO\nSafety\tO\nprogram\tO\n.\tO\n\nColombia\tT-1\nwas\tO\npermitted\tO\nto\tO\nadd\tO\na\tO\nsingle\tO\nadditional\tO\nround-trip\tO\nflight\tO\nto\tO\nits\tO\ncurrent\tO\nNew\tO\nYork\tO\nservice\tO\n,\tO\nalthough\tO\nit\tO\nwill\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\ndo\tO\nso\tO\nwhile\tO\nunder\tO\nCategory\tO\nTwo\tO\n(\tO\nConditional\tO\n)\tO\nstatus\tO\nunder\tO\nthe\tO\nFederal\tB-ORG\nAviation\tI-ORG\nAdministration\tI-ORG\n's\tO\nInternational\tO\nAviation\tO\nSafety\tO\nprogram\tO\n.\tT-0\n\nColombia\tO\nwas\tO\npermitted\tO\nto\tO\nadd\tO\na\tO\nsingle\tO\nadditional\tO\nround-trip\tT-2\nflight\tT-2\nto\tO\nits\tO\ncurrent\tO\nNew\tO\nYork\tO\nservice\tO\n,\tO\nalthough\tO\nit\tO\nwill\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\ndo\tO\nso\tO\nwhile\tO\nunder\tO\nCategory\tT-0\nTwo\tO\n(\tO\nConditional\tO\n)\tO\nstatus\tO\nunder\tO\nthe\tO\nFederal\tO\nAviation\tO\nAdministration\tT-1\n's\tT-1\nInternational\tB-MISC\nAviation\tI-MISC\nSafety\tI-MISC\nprogram\tI-MISC\n.\tO\n\nColombia\tB-LOC\nwould\tT-0\nbe\tO\nallowed\tO\nto\tO\nadd\tO\nnew\tO\nservice\tO\nwhen\tO\nits\tO\nsafety\tO\nassessment\tO\nhas\tO\nbeen\tO\nimproved\tO\n,\tO\nthe\tO\ndepartment\tO\nsaid\tO\n.\tO\n\nThe\tO\nagreement\tO\nresolved\tO\na\tO\ndispute\tO\nthat\tO\narose\tO\nin\tO\nJune\tO\nwhen\tO\nColombia\tO\nturned\tO\ndown\tO\nAmerican\tB-ORG\n's\tO\nrequest\tO\nto\tO\noperate\tT-0\nflights\tO\nbetween\tO\nNew\tT-1\nYork\tT-1\nand\tO\nBogota\tT-2\n,\tO\na\tO\ndenial\tO\nthat\tO\nprompted\tO\nthe\tO\nUnited\tT-3\nStates\tT-3\nto\tO\ncharge\tO\nthat\tO\nthe\tO\nColombians\tO\nwere\tO\nbreaking\tO\na\tO\nbilateral\tO\naviation\tT-4\nagreement\tO\nand\tO\nto\tO\npropose\tO\nsanctions\tO\nagainst\tO\none\tO\nof\tO\ntwo\tO\nColombian\tO\nairlines\tO\n,\tO\nAvianca\tO\nand\tO\nACES\tO\n.\tO\n\nThe\tO\nagreement\tO\nresolved\tO\na\tO\ndispute\tO\nthat\tO\narose\tO\nin\tO\nJune\tO\nwhen\tO\nColombia\tT-1\nturned\tO\ndown\tO\nAmerican\tO\n's\tO\nrequest\tO\nto\tO\noperate\tO\nflights\tO\nbetween\tO\nNew\tB-LOC\nYork\tI-LOC\nand\tO\nBogota\tO\n,\tO\na\tO\ndenial\tO\nthat\tO\nprompted\tO\nthe\tO\nUnited\tT-0\nStates\tT-0\nto\tO\ncharge\tO\nthat\tO\nthe\tO\nColombians\tO\nwere\tO\nbreaking\tO\na\tO\nbilateral\tO\naviation\tO\nagreement\tO\nand\tO\nto\tO\npropose\tO\nsanctions\tO\nagainst\tO\none\tO\nof\tO\ntwo\tO\nColombian\tO\nairlines\tO\n,\tO\nAvianca\tO\nand\tO\nACES\tO\n.\tO\n\nThe\tO\nagreement\tO\nresolved\tO\na\tO\ndispute\tO\nthat\tO\narose\tO\nin\tO\nJune\tO\nwhen\tO\nColombia\tO\nturned\tO\ndown\tO\nAmerican\tT-1\n's\tT-1\nrequest\tO\nto\tO\noperate\tO\nflights\tO\nbetween\tO\nNew\tT-2\nYork\tT-2\nand\tO\nBogota\tB-LOC\n,\tO\na\tO\ndenial\tO\nthat\tO\nprompted\tO\nthe\tO\nUnited\tO\nStates\tO\nto\tO\ncharge\tO\nthat\tO\nthe\tO\nColombians\tT-0\nwere\tO\nbreaking\tO\na\tO\nbilateral\tO\naviation\tO\nagreement\tO\nand\tO\nto\tO\npropose\tO\nsanctions\tO\nagainst\tO\none\tO\nof\tO\ntwo\tO\nColombian\tO\nairlines\tO\n,\tO\nAvianca\tO\nand\tO\nACES\tO\n.\tO\n\nThe\tO\nagreement\tO\nresolved\tO\na\tO\ndispute\tO\nthat\tO\narose\tO\nin\tO\nJune\tO\nwhen\tO\nColombia\tT-2\nturned\tO\ndown\tO\nAmerican\tO\n's\tO\nrequest\tO\nto\tO\noperate\tO\nflights\tO\nbetween\tO\nNew\tT-3\nYork\tT-3\nand\tO\nBogota\tT-4\n,\tO\na\tO\ndenial\tO\nthat\tO\nprompted\tT-0\nthe\tT-0\nUnited\tB-LOC\nStates\tI-LOC\nto\tT-1\ncharge\tT-1\nthat\tO\nthe\tO\nColombians\tO\nwere\tO\nbreaking\tO\na\tO\nbilateral\tO\naviation\tO\nagreement\tO\nand\tO\nto\tO\npropose\tO\nsanctions\tO\nagainst\tO\none\tO\nof\tO\ntwo\tO\nColombian\tO\nairlines\tO\n,\tO\nAvianca\tO\nand\tO\nACES\tO\n.\tO\n\nThe\tO\nagreement\tO\nresolved\tO\na\tO\ndispute\tO\nthat\tO\narose\tO\nin\tO\nJune\tT-1\nwhen\tO\nColombia\tO\nturned\tO\ndown\tO\nAmerican\tO\n's\tO\nrequest\tO\nto\tO\noperate\tO\nflights\tO\nbetween\tO\nNew\tO\nYork\tO\nand\tO\nBogota\tO\n,\tO\na\tO\ndenial\tO\nthat\tO\nprompted\tO\nthe\tO\nUnited\tO\nStates\tO\nto\tT-0\ncharge\tT-0\nthat\tT-0\nthe\tT-0\nColombians\tB-MISC\nwere\tO\nbreaking\tO\na\tO\nbilateral\tT-2\naviation\tO\nagreement\tO\nand\tO\nto\tO\npropose\tO\nsanctions\tO\nagainst\tO\none\tO\nof\tO\ntwo\tO\nColombian\tT-3\nairlines\tT-3\n,\tO\nAvianca\tO\nand\tO\nACES\tO\n.\tO\n\nThe\tO\nagreement\tO\nresolved\tO\na\tO\ndispute\tO\nthat\tO\narose\tO\nin\tO\nJune\tO\nwhen\tO\nColombia\tO\nturned\tO\ndown\tO\nAmerican\tO\n's\tO\nrequest\tO\nto\tO\noperate\tO\nflights\tO\nbetween\tO\nNew\tO\nYork\tO\nand\tO\nBogota\tO\n,\tO\na\tO\ndenial\tO\nthat\tO\nprompted\tO\nthe\tO\nUnited\tO\nStates\tO\nto\tO\ncharge\tO\nthat\tO\nthe\tO\nColombians\tO\nwere\tO\nbreaking\tO\na\tO\nbilateral\tO\naviation\tO\nagreement\tO\nand\tO\nto\tO\npropose\tO\nsanctions\tO\nagainst\tT-2\none\tO\nof\tO\ntwo\tO\nColombian\tB-MISC\nairlines\tT-3\n,\tO\nAvianca\tT-0\nand\tO\nACES\tT-1\n.\tO\n\nThe\tO\nagreement\tT-2\nresolved\tO\na\tO\ndispute\tO\nthat\tO\narose\tO\nin\tO\nJune\tO\nwhen\tO\nColombia\tO\nturned\tO\ndown\tO\nAmerican\tO\n's\tO\nrequest\tO\nto\tO\noperate\tO\nflights\tO\nbetween\tO\nNew\tO\nYork\tO\nand\tO\nBogota\tO\n,\tO\na\tO\ndenial\tO\nthat\tO\nprompted\tO\nthe\tO\nUnited\tO\nStates\tO\nto\tO\ncharge\tO\nthat\tO\nthe\tO\nColombians\tT-0\nwere\tO\nbreaking\tO\na\tO\nbilateral\tO\naviation\tO\nagreement\tO\nand\tO\nto\tO\npropose\tT-3\nsanctions\tT-3\nagainst\tO\none\tO\nof\tO\ntwo\tO\nColombian\tT-1\nairlines\tT-1\n,\tO\nAvianca\tB-ORG\nand\tO\nACES\tO\n.\tO\n\nThe\tO\nagreement\tT-1\nresolved\tO\na\tO\ndispute\tO\nthat\tO\narose\tO\nin\tO\nJune\tT-3\nwhen\tO\nColombia\tT-4\nturned\tO\ndown\tO\nAmerican\tT-5\n's\tO\nrequest\tO\nto\tO\noperate\tO\nflights\tO\nbetween\tO\nNew\tO\nYork\tO\nand\tO\nBogota\tO\n,\tO\na\tO\ndenial\tO\nthat\tO\nprompted\tO\nthe\tO\nUnited\tO\nStates\tO\nto\tO\ncharge\tO\nthat\tO\nthe\tO\nColombians\tO\nwere\tO\nbreaking\tT-2\na\tO\nbilateral\tT-6\naviation\tO\nagreement\tO\nand\tO\nto\tO\npropose\tO\nsanctions\tO\nagainst\tO\none\tO\nof\tO\ntwo\tO\nColombian\tO\nairlines\tT-0\n,\tO\nAvianca\tO\nand\tO\nACES\tB-ORG\n.\tO\n\nClean\tO\ntanker\tO\nfixtures\tT-0\nand\tO\nenquiries\tO\n-\tO\n1754\tO\nGMT\tB-MISC\n.\tO\n\n-\tO\nMIDEAST\tT-0\nGULF\tT-0\n/\tO\nRED\tB-LOC\nSEA\tI-LOC\n\nKonpolis\tB-ORG\n75\tO\n1/9\tO\nMideast\tO\n/\tO\nIndonesia\tT-0\nW112.5\tO\nKPC\tO\n.\tO\n\nKonpolis\tT-0\n75\tO\n1/9\tO\nMideast\tB-LOC\n/\tO\nIndonesia\tT-1\nW112.5\tO\nKPC\tO\n.\tO\n\nKonpolis\tO\n75\tO\n1/9\tO\nMideast\tT-1\n/\tO\nIndonesia\tB-LOC\nW112.5\tT-0\nKPC\tO\n.\tO\n\nKonpolis\tO\n75\tO\n1/9\tO\nMideast\tT-0\n/\tO\nIndonesia\tO\nW112.5\tO\nKPC\tB-ORG\n.\tO\n\nTBN\tB-ORG\n30\tT-0\n6/9\tT-0\nMideast\tT-2\n/\tO\nW.C.\tT-1\nIndia\tT-1\nW200\tT-1\n,\tO\nE.C.India\tO\nW195\tO\nIOC\tO\n.\tO\n\nTBN\tT-1\n30\tT-1\n6/9\tT-1\nMideast\tB-LOC\n/\tO\nW.C.\tO\nIndia\tT-0\nW200\tO\n,\tO\nE.C.India\tO\nW195\tO\nIOC\tO\n.\tO\n\nTBN\tO\n30\tO\n6/9\tO\nMideast\tO\n/\tO\nW.C.\tB-LOC\nIndia\tI-LOC\nW200\tT-1\n,\tO\nE.C.India\tT-0\nW195\tO\nIOC\tO\n.\tT-0\n\nTBN\tO\n30\tO\n6/9\tO\nMideast\tO\n/\tO\nW.C.\tO\nIndia\tO\nW200\tO\n,\tO\nE.C.India\tB-LOC\nW195\tT-0\nIOC\tO\n.\tO\n\nTBN\tO\n30\tO\n6/9\tO\nMideast\tO\n/\tO\nW.C.\tO\nIndia\tO\nW200\tO\n,\tO\nE.C.India\tT-1\nW195\tT-0\nIOC\tB-ORG\n.\tT-1\n\nPetrobulk\tB-ORG\nRainbow\tI-ORG\n28\tO\n24/8\tO\nOkinawa\tT-0\n/\tO\nInchon\tO\n$\tO\n190,000\tO\nHonam\tO\n.\tO\n\nPetrobulk\tO\nRainbow\tO\n28\tO\n24/8\tO\nOkinawa\tT-0\n/\tO\nInchon\tB-LOC\n$\tO\n190,000\tO\nHonam\tO\n.\tO\n\nPetrobulk\tT-0\nRainbow\tT-0\n28\tO\n24/8\tO\nOkinawa\tO\n/\tO\nInchon\tT-1\n$\tO\n190,000\tO\nHonam\tB-ORG\n.\tO\n\nTBN\tB-ORG\n30\tT-0\n15/9\tT-0\nConstanza\tT-1\n/\tO\nInia\tO\n$\tO\n700,000\tO\nIOC\tO\n.\tO\n\nTBN\tO\n30\tT-0\n15/9\tT-0\nConstanza\tB-LOC\n/\tO\nInia\tT-1\n$\tO\n700,000\tO\nIOC\tO\n.\tO\n\nTBN\tT-0\n30\tO\n15/9\tO\nConstanza\tO\n/\tO\nInia\tB-LOC\n$\tO\n700,000\tO\nIOC\tO\n.\tO\n\nTBN\tT-0\n30\tO\n15/9\tO\nConstanza\tT-1\n/\tO\nInia\tO\n$\tO\n700,000\tO\nIOC\tB-ORG\n.\tO\n\n-\tO\nUK\tB-LOC\n/\tO\nCONT\tT-0\n\nPort\tB-ORG\nChristine\tI-ORG\n36,5\tO\n3/9\tO\nPembroke\tT-0\n/\tO\nUS\tO\nW145\tO\nStentex\tO\n.\tO\n\nPort\tO\nChristine\tO\n36,5\tO\n3/9\tO\nPembroke\tB-LOC\n/\tO\nUS\tT-0\nW145\tO\nStentex\tO\n.\tO\n\nPort\tO\nChristine\tO\n36,5\tO\n3/9\tO\nPembroke\tO\n/\tO\nUS\tB-LOC\nW145\tT-0\nStentex\tT-0\n.\tO\n\nPort\tT-1\nChristine\tT-1\n36,5\tO\n3/9\tO\nPembroke\tT-0\n/\tO\nUS\tO\nW145\tO\nStentex\tB-ORG\n.\tO\n\nKpaitan\tB-ORG\nStankov\tI-ORG\n69\tO\n31/8\tO\nSt\tT-0\nCroix\tT-0\n/\tO\nUSAC\tO\nW125\tO\nHess\tO\n.\tO\n\nKpaitan\tT-0\nStankov\tT-0\n69\tO\n31/8\tO\nSt\tB-LOC\nCroix\tI-LOC\n/\tO\nUSAC\tO\nW125\tO\nHess\tO\n.\tO\n\nKpaitan\tT-0\nStankov\tT-0\n69\tO\n31/8\tO\nSt\tO\nCroix\tO\n/\tO\nUSAC\tB-LOC\nW125\tO\nHess\tO\n.\tO\n\nKpaitan\tO\nStankov\tO\n69\tO\n31/8\tO\nSt\tT-0\nCroix\tT-0\n/\tO\nUSAC\tO\nW125\tO\nHess\tB-ORG\n.\tO\n\nAP\tB-ORG\nMoller\tI-ORG\n30\tT-0\n31/8\tT-0\nCaribs\tO\n/\tO\nJapan\tO\n$\tO\n875,000\tO\nBP\tT-1\n.\tO\n\nAP\tO\nMoller\tO\n30\tO\n31/8\tO\nCaribs\tB-LOC\n/\tO\nJapan\tT-0\n$\tO\n875,000\tO\nBP\tO\n.\tO\n\nAP\tO\nMoller\tO\n30\tO\n31/8\tO\nCaribs\tO\n/\tO\nJapan\tB-LOC\n$\tO\n875,000\tT-0\nBP\tO\n.\tO\n\nAP\tO\nMoller\tO\n30\tO\n31/8\tO\nCaribs\tO\n/\tO\nJapan\tT-1\n$\tO\n875,000\tT-0\nBP\tB-ORG\n.\tT-0\n\nTiber\tB-ORG\n29\tO\n2/9\tO\nCaribs\tO\n/\tO\noptions\tO\nW265\tO\nStinnes\tT-0\n.\tO\n\nTiber\tO\n29\tO\n2/9\tO\nCaribs\tB-LOC\n/\tO\noptions\tO\nW265\tO\nStinnes\tT-0\n.\tO\n\nTiber\tO\n29\tO\n2/9\tO\nCaribs\tO\n/\tO\noptions\tT-1\nW265\tO\nStinnes\tB-ORG\n.\tT-0\n\n-\tO\nMIDEAST\tT-0\nGULF\tT-0\n/\tO\nRED\tB-LOC\nSEA\tI-LOC\n\nTenacity\tB-ORG\n70\tO\n24/08\tO\nMideast\tT-0\n/\tO\nSouth\tO\nKorea\tO\nW145\tO\nSamsung\tO\n.\tO\n\nTenacity\tT-0\n70\tO\n24/08\tO\nMideast\tB-LOC\n/\tO\nSouth\tT-2\nKorea\tT-2\nW145\tO\nSamsung\tT-1\n.\tO\n\nTenacity\tT-0\n70\tO\n24/08\tO\nMideast\tT-2\n/\tO\nSouth\tB-LOC\nKorea\tI-LOC\nW145\tO\nSamsung\tT-1\n.\tO\n\nTenacity\tT-1\n70\tO\n24/08\tT-0\nMideast\tO\n/\tO\nSouth\tO\nKorea\tO\nW145\tO\nSamsung\tB-ORG\n.\tO\n\nSKS\tB-ORG\nTana\tI-ORG\n70\tO\n03/09\tO\nMideast\tT-0\n/\tO\nJapan\tO\nW145\tO\nCNR\tO\n.\tO\n\nSKS\tO\nTana\tO\n70\tO\n03/09\tO\nMideast\tB-LOC\n/\tO\nJapan\tT-0\nW145\tO\nCNR\tO\n.\tO\n\nSKS\tO\nTana\tO\n70\tO\n03/09\tO\nMideast\tT-0\n/\tO\nJapan\tB-LOC\nW145\tT-1\nCNR\tT-1\n.\tO\n\nSKS\tT-1\nTana\tT-1\n70\tO\n03/09\tO\nMideast\tT-2\n/\tO\nJapan\tT-0\nW145\tO\nCNR\tB-ORG\n.\tO\n\nNorthsea\tB-ORG\nChaser\tI-ORG\n55\tT-0\n12/09\tT-0\nMideast\tT-1\n/\tT-1\nJapan\tT-1\nW167.5\tO\nJomo\tO\n.\tO\n\nNorthsea\tO\nChaser\tO\n55\tO\n12/09\tO\nMideast\tT-0\n/\tO\nJapan\tB-LOC\nW167.5\tT-1\nJomo\tT-1\n.\tO\n\nNorthsea\tO\nChaser\tO\n55\tO\n12/09\tO\nMideast\tT-0\n/\tO\nJapan\tT-1\nW167.5\tO\nJomo\tB-ORG\n.\tO\n\nSibonina\tB-ORG\n55\tO\n13/09\tO\nRed\tT-0\nSea\tT-0\n/\tT-0\nJapan\tT-0\nW160\tT-0\nMarubeni\tT-0\n.\tO\n\nSibonina\tT-0\n55\tT-0\n13/09\tT-0\nRed\tB-LOC\nSea\tI-LOC\n/\tO\nJapan\tT-1\nW160\tO\nMarubeni\tO\n.\tO\n\nSibonina\tT-1\n55\tO\n13/09\tO\nRed\tO\nSea\tO\n/\tO\nJapan\tB-LOC\nW160\tT-0\nMarubeni\tT-0\n.\tO\n\nSibonina\tO\n55\tO\n13/09\tO\nRed\tT-0\nSea\tT-0\n/\tO\nJapan\tT-1\nW160\tO\nMarubeni\tB-ORG\n.\tO\n\n-\tO\nASIA\tT-0\n/\tO\nPACIFIC\tB-LOC\n\nNeptune\tB-ORG\nCrux\tI-ORG\n30\tO\n02/09\tO\nSingapore\tT-0\n/\tO\noptions\tO\n$\tO\n185,000\tO\nSietco\tO\n.\tO\n\nNeptune\tT-0\nCrux\tT-0\n30\tT-0\n02/09\tT-0\nSingapore\tB-LOC\n/\tO\noptions\tO\n$\tO\n185,000\tO\nSietco\tO\n.\tO\n\nNeptune\tO\nCrux\tO\n30\tO\n02/09\tO\nSingapore\tT-0\n/\tO\noptions\tO\n$\tO\n185,000\tO\nSietco\tB-ORG\n.\tO\n\nWorld\tB-ORG\nBridge\tI-ORG\n30\tO\n03/09\tO\nSouth\tT-0\nKorea\tT-0\n/\tO\nJapan\tO\nrnr\tO\nCNR\tO\n.\tO\n\nWorld\tT-0\nBridge\tT-0\n30\tO\n03/09\tO\nSouth\tB-LOC\nKorea\tI-LOC\n/\tO\nJapan\tT-1\nrnr\tO\nCNR\tO\n.\tO\n\nWorld\tT-0\nBridge\tT-2\n30\tO\n03/09\tO\nSouth\tT-1\nKorea\tT-1\n/\tO\nJapan\tB-LOC\nrnr\tO\nCNR\tO\n.\tO\n\nWorld\tO\nBridge\tO\n30\tO\n03/09\tO\nSouth\tT-0\nKorea\tT-0\n/\tO\nJapan\tT-1\nrnr\tO\nCNR\tB-ORG\n.\tO\n\nFulmar\tT-0\n30\tT-0\n28/08\tT-0\nUlsan\tB-LOC\n/\tO\nYosu\tT-1\n$\tO\n105,000\tO\nLG\tO\nCaltex\tO\n.\tO\n\nFulmar\tT-0\n30\tT-0\n28/08\tT-0\nUlsan\tT-0\n/\tT-0\nYosu\tT-0\n$\tT-0\n105,000\tT-0\nLG\tB-ORG\nCaltex\tI-ORG\n.\tO\n\nHemina\tB-ORG\n33\tO\n05/09\tO\nEleusis\tO\n/\tO\nUKCM\tT-0\nW155\tT-0\nCNR\tT-0\n.\tO\n\nHemina\tO\n33\tO\n05/09\tO\nEleusis\tB-ORG\n/\tO\nUKCM\tT-0\nW155\tO\nCNR\tO\n.\tO\n\nHemina\tO\n33\tO\n05/09\tO\nEleusis\tO\n/\tO\nUKCM\tB-ORG\nW155\tT-0\nCNR\tT-0\n.\tT-0\n\nHemina\tT-0\n33\tO\n05/09\tO\nEleusis\tT-1\n/\tO\nUKCM\tO\nW155\tO\nCNR\tB-ORG\n.\tO\n\n--\tO\nLondon\tB-ORG\nNewsroom\tI-ORG\n,\tO\n+44\tT-0\n171\tT-0\n542\tT-0\n8980\tT-0\n\nCRICKET\tT-0\n-\tO\nPAKISTAN\tB-LOC\n229-1\tO\nV\tO\nENGLAND\tO\n-\tO\nclose\tO\n.\tO\n\nCRICKET\tT-0\n-\tT-0\nPAKISTAN\tT-0\n229-1\tO\nV\tO\nENGLAND\tB-LOC\n-\tO\nclose\tT-1\n.\tO\n\nSaeed\tB-PER\nAnwar\tI-PER\nnot\tT-0\nout\tT-0\n116\tO\n\nAamir\tB-PER\nSohail\tI-PER\nc\tO\nCork\tT-0\nb\tO\nCroft\tO\n46\tO\n\nAamir\tT-1\nSohail\tT-1\nc\tO\nCork\tB-PER\nb\tT-0\nCroft\tT-0\n46\tT-0\n\nIjaz\tB-PER\nAhmed\tI-PER\nnot\tO\nout\tT-0\n58\tO\n\nTo\tT-0\nbat\tT-0\n-\tO\nInzamam-ul-Haq\tO\n,\tO\nSalim\tB-PER\nMalik\tI-PER\n,\tO\nAsif\tO\nMujtaba\tO\n,\tO\nWasim\tO\nAkram\tO\n,\tO\nMoin\tO\nKhan\tO\n,\tO\nMushtaq\tO\nAhmed\tO\n,\tO\nWaqar\tO\nYounis\tO\n,\tO\nMohammad\tO\nAkam\tO\n\nTo\tT-0\nbat\tT-0\n-\tO\nInzamam-ul-Haq\tO\n,\tO\nSalim\tT-1\nMalik\tT-1\n,\tO\nAsif\tB-PER\nMujtaba\tI-PER\n,\tO\nWasim\tO\nAkram\tO\n,\tO\nMoin\tO\nKhan\tO\n,\tO\nMushtaq\tO\nAhmed\tO\n,\tO\nWaqar\tO\nYounis\tO\n,\tO\nMohammad\tO\nAkam\tO\n\nTo\tO\nbat\tT-0\n-\tO\nInzamam-ul-Haq\tO\n,\tO\nSalim\tO\nMalik\tO\n,\tO\nAsif\tO\nMujtaba\tO\n,\tO\nWasim\tO\nAkram\tO\n,\tO\nMoin\tB-PER\nKhan\tI-PER\n,\tO\nMushtaq\tO\nAhmed\tO\n,\tO\nWaqar\tO\nYounis\tO\n,\tO\nMohammad\tO\nAkam\tO\n\nTo\tO\nbat\tO\n-\tO\nInzamam-ul-Haq\tT-0\n,\tO\nSalim\tT-1\nMalik\tT-1\n,\tO\nAsif\tT-2\nMujtaba\tT-2\n,\tO\nWasim\tT-3\nAkram\tT-3\n,\tO\nMoin\tT-4\nKhan\tT-4\n,\tO\nMushtaq\tB-PER\nAhmed\tI-PER\n,\tO\nWaqar\tT-5\nYounis\tT-5\n,\tO\nMohammad\tO\nAkam\tO\n\nRTRS\tB-ORG\n-\tO\nGolf\tO\n:\tO\nNorman\tT-1\nsacks\tT-1\nhis\tO\ncoach\tT-2\nafter\tO\ndisappointing\tT-3\nseason\tO\n.\tO\n\nRTRS\tO\n-\tO\nGolf\tO\n:\tO\nNorman\tB-PER\nsacks\tT-1\nhis\tT-2\ncoach\tO\nafter\tO\ndisappointing\tT-0\nseason\tO\n.\tO\n\nWorld\tO\nnumber\tO\none\tO\ngolfer\tO\nGreg\tB-PER\nNorman\tI-PER\nhas\tT-2\nsacked\tT-2\nhis\tO\ncoach\tT-0\nButch\tO\nHarmon\tO\nafter\tO\na\tO\ndisappointing\tO\nseason\tO\n.\tO\n\nWorld\tO\nnumber\tO\none\tO\ngolfer\tO\nGreg\tO\nNorman\tO\nhas\tO\nsacked\tO\nhis\tO\ncoach\tT-0\nButch\tB-PER\nHarmon\tI-PER\nafter\tO\na\tO\ndisappointing\tO\nseason\tO\n.\tO\n\n\"\tO\nButch\tB-PER\nand\tO\nI\tO\nare\tT-1\nfinished\tO\n,\tO\n\"\tO\nNorman\tT-0\ntold\tO\nreporters\tO\non\tO\nThursday\tO\nbefore\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nWorld\tO\nSeries\tO\nof\tO\nGolf\tO\nin\tO\nAkron\tT-2\n,\tO\nOhio\tT-3\n.\tO\n\n\"\tO\nButch\tO\nand\tO\nI\tO\nare\tO\nfinished\tO\n,\tO\n\"\tO\nNorman\tB-PER\ntold\tT-0\nreporters\tT-1\non\tO\nThursday\tO\nbefore\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nWorld\tO\nSeries\tO\nof\tO\nGolf\tO\nin\tO\nAkron\tO\n,\tO\nOhio\tO\n.\tT-2\n\n\"\tO\nButch\tO\nand\tO\nI\tO\nare\tO\nfinished\tO\n,\tO\n\"\tO\nNorman\tO\ntold\tT-0\nreporters\tO\non\tO\nThursday\tO\nbefore\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nWorld\tB-MISC\nSeries\tI-MISC\nof\tI-MISC\nGolf\tI-MISC\nin\tO\nAkron\tT-1\n,\tO\nOhio\tO\n.\tO\n\n\"\tO\nButch\tO\nand\tO\nI\tO\nare\tO\nfinished\tT-0\n,\tO\n\"\tO\nNorman\tT-3\ntold\tT-1\nreporters\tO\non\tO\nThursday\tO\nbefore\tO\nthe\tO\nstart\tT-2\nof\tO\nthe\tO\nWorld\tO\nSeries\tO\nof\tO\nGolf\tO\nin\tT-4\nAkron\tB-LOC\n,\tO\nOhio\tT-5\n.\tO\n\n\"\tO\nButch\tO\nand\tO\nI\tO\nare\tO\nfinished\tO\n,\tO\n\"\tO\nNorman\tO\ntold\tO\nreporters\tO\non\tO\nThursday\tO\nbefore\tO\nthe\tO\nstart\tO\nof\tO\nthe\tO\nWorld\tO\nSeries\tO\nof\tO\nGolf\tO\nin\tO\nAkron\tT-0\n,\tO\nOhio\tB-LOC\n.\tO\n\nNorman\tB-PER\n,\tO\na\tT-0\ntwo-time\tT-2\nBritish\tO\nOpen\tO\nchampion\tT-3\n,\tO\nparted\tT-1\nways\tO\nwith\tO\nhis\tO\nlong-time\tO\nmentor\tO\nafter\tO\ndrawing\tO\na\tO\nblank\tO\nin\tO\nthis\tO\nyear\tO\n's\tO\nfour\tO\nmajors\tO\n,\tO\nwinning\tO\ntwo\tO\ntournaments\tO\nworldwide\tO\n.\tO\n\nNorman\tT-1\n,\tO\na\tO\ntwo-time\tT-0\nBritish\tB-MISC\nOpen\tI-MISC\nchampion\tO\n,\tO\nparted\tO\nways\tO\nwith\tO\nhis\tO\nlong-time\tO\nmentor\tO\nafter\tO\ndrawing\tT-2\na\tO\nblank\tO\nin\tO\nthis\tO\nyear\tO\n's\tO\nfour\tO\nmajors\tO\n,\tO\nwinning\tO\ntwo\tO\ntournaments\tO\nworldwide\tO\n.\tO\n\nThe\tT-2\nblonde\tT-2\nAustralian\tB-MISC\nopened\tT-1\nwith\tO\na\tO\nlevel\tO\npar\tO\nround\tO\nof\tO\n70\tO\nin\tO\nAkron\tO\n,\tO\nleaving\tO\nhim\tO\nfour\tO\nshots\tO\nadrift\tO\nof\tO\nthe\tO\nleaders\tO\n,\tO\nAmericans\tO\nBilly\tO\nMayfair\tO\nand\tO\nPaul\tO\nGoydos\tO\nand\tO\nJapan\tO\n's\tO\nHidemichi\tO\nTanaki\tO\n.\tO\n\nThe\tO\nblonde\tO\nAustralian\tO\nopened\tO\nwith\tO\na\tO\nlevel\tO\npar\tO\nround\tO\nof\tO\n70\tO\nin\tT-0\nAkron\tB-LOC\n,\tO\nleaving\tO\nhim\tO\nfour\tO\nshots\tO\nadrift\tO\nof\tO\nthe\tO\nleaders\tO\n,\tO\nAmericans\tO\nBilly\tO\nMayfair\tO\nand\tO\nPaul\tO\nGoydos\tO\nand\tO\nJapan\tO\n's\tO\nHidemichi\tO\nTanaki\tO\n.\tO\n\nThe\tO\nblonde\tO\nAustralian\tO\nopened\tT-1\nwith\tO\na\tO\nlevel\tO\npar\tO\nround\tO\nof\tO\n70\tO\nin\tO\nAkron\tO\n,\tO\nleaving\tO\nhim\tO\nfour\tO\nshots\tO\nadrift\tO\nof\tO\nthe\tO\nleaders\tT-0\n,\tO\nAmericans\tB-MISC\nBilly\tO\nMayfair\tO\nand\tO\nPaul\tO\nGoydos\tO\nand\tO\nJapan\tO\n's\tO\nHidemichi\tO\nTanaki\tO\n.\tO\n\nThe\tO\nblonde\tO\nAustralian\tT-0\nopened\tO\nwith\tO\na\tO\nlevel\tO\npar\tO\nround\tO\nof\tO\n70\tO\nin\tO\nAkron\tT-1\n,\tO\nleaving\tO\nhim\tO\nfour\tO\nshots\tO\nadrift\tO\nof\tO\nthe\tO\nleaders\tO\n,\tO\nAmericans\tT-4\nBilly\tB-PER\nMayfair\tI-PER\nand\tO\nPaul\tT-2\nGoydos\tT-2\nand\tO\nJapan\tO\n's\tO\nHidemichi\tT-3\nTanaki\tT-3\n.\tO\n\nThe\tO\nblonde\tO\nAustralian\tO\nopened\tT-3\nwith\tO\na\tO\nlevel\tO\npar\tO\nround\tO\nof\tO\n70\tO\nin\tO\nAkron\tO\n,\tO\nleaving\tT-4\nhim\tO\nfour\tO\nshots\tO\nadrift\tO\nof\tO\nthe\tO\nleaders\tT-0\n,\tO\nAmericans\tT-1\nBilly\tT-2\nMayfair\tT-2\nand\tO\nPaul\tB-PER\nGoydos\tI-PER\nand\tO\nJapan\tO\n's\tO\nHidemichi\tT-5\nTanaki\tT-5\n.\tO\n\nThe\tO\nblonde\tO\nAustralian\tT-1\nopened\tO\nwith\tO\na\tO\nlevel\tO\npar\tO\nround\tO\nof\tO\n70\tO\nin\tO\nAkron\tT-0\n,\tO\nleaving\tO\nhim\tO\nfour\tO\nshots\tO\nadrift\tO\nof\tO\nthe\tO\nleaders\tO\n,\tO\nAmericans\tO\nBilly\tO\nMayfair\tO\nand\tO\nPaul\tO\nGoydos\tO\nand\tT-2\nJapan\tB-LOC\n's\tO\nHidemichi\tO\nTanaki\tO\n.\tO\n\nThe\tO\nblonde\tO\nAustralian\tO\nopened\tO\nwith\tO\na\tO\nlevel\tO\npar\tO\nround\tO\nof\tO\n70\tO\nin\tO\nAkron\tO\n,\tO\nleaving\tT-2\nhim\tO\nfour\tO\nshots\tO\nadrift\tO\nof\tO\nthe\tO\nleaders\tO\n,\tO\nAmericans\tO\nBilly\tO\nMayfair\tT-0\nand\tO\nPaul\tO\nGoydos\tT-1\nand\tO\nJapan\tO\n's\tO\nHidemichi\tB-PER\nTanaki\tI-PER\n.\tO\n\nOn\tO\nWednesday\tO\nNorman\tB-PER\ndescribed\tT-0\nthis\tO\nyear\tO\nas\tO\nhis\tO\nworst\tO\non\tO\nthe\tO\nprofessional\tO\ncircuit\tO\nsince\tO\n1991\tO\n,\tO\nwhen\tO\nhe\tO\nfailed\tO\nto\tO\nwin\tO\na\tO\ntournament\tO\n.\tO\n\n\"\tO\nMy\tO\napplication\tT-1\nthis\tO\nyear\tO\nhas\tO\nbeen\tO\nstrange\tT-0\n,\tO\n\"\tO\nNorman\tB-PER\nsaid\tO\n.\tO\n\"\tO\n\nSoccer\tO\n-\tO\nArab\tB-MISC\nteam\tO\nbreaks\tT-0\nnew\tO\nground\tO\nin\tO\nIsrael\tO\n.\tO\n\nSoccer\tT-0\n-\tO\nArab\tO\nteam\tO\nbreaks\tO\nnew\tO\nground\tO\nin\tT-1\nIsrael\tB-LOC\n.\tO\n\nTAIBE\tB-LOC\n,\tO\nIsrael\tT-0\n1996-08-23\tT-0\n\nFor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tT-1\nIsraeli\tB-MISC\nhistory\tO\n,\tO\nan\tO\nArab\tO\nteam\tO\nwill\tO\ntake\tT-0\nthe\tO\nfield\tO\nwhen\tO\nthe\tO\nNational\tO\nLeague\tO\nsoccer\tO\nseason\tO\nstarts\tO\non\tO\nSaturday\tO\n.\tO\n\nFor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\nIsraeli\tT-0\nhistory\tO\n,\tO\nan\tT-1\nArab\tB-MISC\nteam\tO\nwill\tO\ntake\tO\nthe\tO\nfield\tO\nwhen\tO\nthe\tO\nNational\tT-2\nLeague\tO\nsoccer\tO\nseason\tO\nstarts\tO\non\tO\nSaturday\tO\n.\tO\n\nFor\tO\nthe\tO\nfirst\tT-1\ntime\tT-1\nin\tO\nIsraeli\tO\nhistory\tO\n,\tO\nan\tO\nArab\tO\nteam\tO\nwill\tO\ntake\tT-2\nthe\tO\nfield\tO\nwhen\tO\nthe\tO\nNational\tB-MISC\nLeague\tI-MISC\nsoccer\tT-4\nseason\tT-4\nstarts\tT-3\non\tO\nSaturday\tO\n.\tO\n\nHapoel\tB-ORG\nTaibe\tI-ORG\nfields\tO\nfour\tO\nJewish\tO\nplayers\tT-0\nand\tO\ntwo\tO\nforeign\tO\nimports\tO\n--\tO\na\tO\nPole\tO\nand\tO\na\tO\nRomanian\tO\n.\tO\n\nHapoel\tT-0\nTaibe\tO\nfields\tO\nfour\tO\nJewish\tB-MISC\nplayers\tO\nand\tO\ntwo\tO\nforeign\tO\nimports\tO\n--\tO\na\tO\nPole\tO\nand\tO\na\tO\nRomanian\tO\n.\tO\n\nHapoel\tO\nTaibe\tO\nfields\tT-1\nfour\tO\nJewish\tO\nplayers\tO\nand\tO\ntwo\tO\nforeign\tT-0\nimports\tT-0\n--\tO\na\tO\nPole\tB-MISC\nand\tO\na\tO\nRomanian\tO\n.\tO\n\nHapoel\tO\nTaibe\tO\nfields\tO\nfour\tO\nJewish\tO\nplayers\tO\nand\tO\ntwo\tO\nforeign\tO\nimports\tO\n--\tO\na\tO\nPole\tT-0\nand\tT-1\na\tT-1\nRomanian\tB-MISC\n.\tO\n\nThe\tO\nrest\tO\nof\tO\nthe\tO\nside\tT-0\nis\tT-1\nmade\tT-1\nup\tT-1\nmainly\tT-2\nof\tO\nMoslem\tB-MISC\nArabs\tI-MISC\n.\tO\n\nThe\tO\nclub\tO\n,\tO\nfounded\tT-0\nin\tT-0\n1961\tO\n,\tO\nhas\tO\na\tO\nloyal\tO\nfollowing\tO\nin\tO\nTaibe\tB-LOC\n,\tO\nan\tO\nArab\tO\ntown\tO\nof\tO\n28,000\tO\nin\tO\nthe\tO\nheart\tO\nof\tO\nIsrael\tO\n.\tO\n\nThe\tT-2\nclub\tT-2\n,\tO\nfounded\tT-3\nin\tO\n1961\tO\n,\tO\nhas\tO\na\tO\nloyal\tO\nfollowing\tO\nin\tO\nTaibe\tT-0\n,\tO\nan\tO\nArab\tB-MISC\ntown\tO\nof\tO\n28,000\tO\nin\tO\nthe\tO\nheart\tO\nof\tO\nIsrael\tO\n.\tO\n\nThe\tO\nclub\tO\n,\tO\nfounded\tT-0\nin\tO\n1961\tO\n,\tO\nhas\tO\na\tO\nloyal\tO\nfollowing\tO\nin\tO\nTaibe\tT-1\n,\tO\nan\tO\nArab\tT-2\ntown\tT-2\nof\tO\n28,000\tO\nin\tO\nthe\tO\nheart\tO\nof\tO\nIsrael\tB-LOC\n.\tO\n\n\"\tO\nThe\tO\nvery\tO\nfirst\tO\nthing\tO\nwe\tO\nthought\tO\nabout\tO\nafter\tO\nwe\tO\nknew\tO\nwe\tO\nwould\tO\nbe\tO\npromoted\tO\nwas\tO\nthe\tO\ngame\tT-2\nagainst\tT-3\nBetar\tB-ORG\nJerusalem\tI-ORG\n,\tO\n\"\tO\nsaid\tO\nTaibe\tT-0\nsupporter\tT-1\nKarem\tO\nHaj\tO\nYihye\tO\n.\tO\n\n\"\tO\nThe\tO\nvery\tO\nfirst\tO\nthing\tO\nwe\tO\nthought\tO\nabout\tO\nafter\tO\nwe\tO\nknew\tO\nwe\tO\nwould\tO\nbe\tO\npromoted\tO\nwas\tO\nthe\tO\ngame\tO\nagainst\tO\nBetar\tT-0\nJerusalem\tT-0\n,\tO\n\"\tO\nsaid\tO\nTaibe\tB-ORG\nsupporter\tT-1\nKarem\tO\nHaj\tO\nYihye\tO\n.\tO\n\n\"\tO\nThe\tO\nvery\tO\nfirst\tO\nthing\tO\nwe\tO\nthought\tO\nabout\tO\nafter\tO\nwe\tO\nknew\tO\nwe\tO\nwould\tO\nbe\tO\npromoted\tO\nwas\tO\nthe\tO\ngame\tT-1\nagainst\tO\nBetar\tO\nJerusalem\tO\n,\tO\n\"\tO\nsaid\tO\nTaibe\tT-2\nsupporter\tT-0\nKarem\tB-PER\nHaj\tI-PER\nYihye\tI-PER\n.\tO\n\nTwo\tO\nweeks\tO\nago\tO\nTaibe\tB-ORG\n,\tO\ncoached\tO\nby\tO\nPole\tO\nWojtek\tO\nLazarek\tO\n,\tO\nmet\tO\nBetar\tO\n,\tO\na\tO\nclub\tO\nclosely\tO\nassociated\tO\nwith\tO\nthe\tO\nright-wing\tO\nLikud\tO\nparty\tO\n,\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\na\tO\nCup\tT-0\nmatch\tO\nin\tO\nJerusalem\tO\n.\tO\n\nTwo\tO\nweeks\tO\nago\tO\nTaibe\tT-1\n,\tO\ncoached\tT-0\nby\tO\nPole\tB-MISC\nWojtek\tO\nLazarek\tO\n,\tO\nmet\tO\nBetar\tO\n,\tO\na\tO\nclub\tO\nclosely\tO\nassociated\tT-2\nwith\tT-2\nthe\tO\nright-wing\tO\nLikud\tO\nparty\tO\n,\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\na\tO\nCup\tO\nmatch\tO\nin\tO\nJerusalem\tO\n.\tO\n\nTwo\tO\nweeks\tO\nago\tO\nTaibe\tO\n,\tO\ncoached\tT-1\nby\tO\nPole\tT-2\nWojtek\tB-PER\nLazarek\tI-PER\n,\tO\nmet\tO\nBetar\tT-3\n,\tO\na\tO\nclub\tT-0\nclosely\tO\nassociated\tO\nwith\tO\nthe\tO\nright-wing\tO\nLikud\tT-4\nparty\tT-4\n,\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\na\tO\nCup\tO\nmatch\tO\nin\tO\nJerusalem\tO\n.\tO\n\nTwo\tO\nweeks\tO\nago\tO\nTaibe\tO\n,\tO\ncoached\tO\nby\tO\nPole\tO\nWojtek\tO\nLazarek\tO\n,\tO\nmet\tO\nBetar\tB-ORG\n,\tO\na\tO\nclub\tO\nclosely\tO\nassociated\tT-0\nwith\tO\nthe\tO\nright-wing\tO\nLikud\tO\nparty\tO\n,\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\na\tO\nCup\tO\nmatch\tO\nin\tO\nJerusalem\tO\n.\tO\n\nTwo\tO\nweeks\tO\nago\tO\nTaibe\tO\n,\tO\ncoached\tO\nby\tO\nPole\tO\nWojtek\tO\nLazarek\tO\n,\tO\nmet\tO\nBetar\tO\n,\tO\na\tO\nclub\tO\nclosely\tO\nassociated\tO\nwith\tO\nthe\tO\nright-wing\tT-1\nLikud\tB-ORG\nparty\tT-2\n,\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\na\tO\nCup\tO\nmatch\tO\nin\tO\nJerusalem\tO\n.\tO\n\nTwo\tO\nweeks\tO\nago\tO\nTaibe\tO\n,\tO\ncoached\tT-0\nby\tO\nPole\tO\nWojtek\tO\nLazarek\tO\n,\tO\nmet\tO\nBetar\tO\n,\tO\na\tO\nclub\tO\nclosely\tO\nassociated\tT-1\nwith\tO\nthe\tO\nright-wing\tO\nLikud\tO\nparty\tO\n,\tO\nfor\tO\nthe\tO\nfirst\tT-2\ntime\tT-2\nin\tO\na\tO\nCup\tB-MISC\nmatch\tO\nin\tO\nJerusalem\tO\n.\tO\n\nTwo\tO\nweeks\tO\nago\tO\nTaibe\tT-1\n,\tO\ncoached\tO\nby\tO\nPole\tO\nWojtek\tO\nLazarek\tO\n,\tO\nmet\tO\nBetar\tO\n,\tO\na\tO\nclub\tO\nclosely\tO\nassociated\tO\nwith\tO\nthe\tO\nright-wing\tO\nLikud\tO\nparty\tO\n,\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\nin\tO\na\tO\nCup\tO\nmatch\tT-0\nin\tO\nJerusalem\tB-LOC\n.\tO\n\nChants\tO\nfrom\tO\nthe\tO\ncrowd\tO\nof\tO\n\"\tO\nDeath\tT-1\nto\tO\nthe\tO\nArabs\tB-MISC\n\"\tO\n,\tO\nand\tO\nbottle-throwing\tT-2\nduring\tO\nthe\tO\ngame\tT-3\nmarred\tT-0\nthe\tO\nmatch\tO\nwhich\tO\nended\tO\nin\tO\na\tO\ngoalless\tT-4\ndraw\tT-4\n.\tO\n\nOne\tO\nTaibe\tB-ORG\nsupporter\tT-0\nrequired\tT-1\nhospital\tO\ntreatment\tT-2\nfor\tO\ncuts\tO\nand\tO\nbruises\tO\nafter\tO\na\tO\nstone\tO\nstruck\tO\nhis\tO\nhead\tO\nas\tO\nhe\tO\nwas\tO\ndriving\tT-3\nfrom\tO\nthe\tO\nstadium\tO\n.\tO\n\n\"\tO\nWe\tO\n're\tO\nused\tO\nto\tO\nhearing\tO\nthe\tO\ntaunts\tO\nof\tO\n\"\tO\nDeath\tO\nto\tO\nthe\tO\nArabs\tB-MISC\n'\tO\n,\tO\n\"\tO\nsaid\tO\nSameh\tT-1\nHaj\tT-1\nYihye\tT-1\n,\tO\na\tO\nTaibe\tO\nresident\tO\nwho\tO\nstudies\tO\nat\tO\nJerusalem\tT-0\n's\tO\nHebrew\tO\nUniversity\tO\n.\tO\n\"\tO\n\n\"\tO\nWe\tO\n're\tO\nused\tO\nto\tO\nhearing\tO\nthe\tO\ntaunts\tO\nof\tO\n\"\tO\nDeath\tO\nto\tO\nthe\tO\nArabs\tO\n'\tO\n,\tO\n\"\tO\nsaid\tT-0\nSameh\tB-PER\nHaj\tI-PER\nYihye\tI-PER\n,\tO\na\tO\nTaibe\tT-2\nresident\tO\nwho\tO\nstudies\tT-3\nat\tO\nJerusalem\tT-1\n's\tT-1\nHebrew\tT-1\nUniversity\tT-1\n.\tO\n\"\tO\n\n\"\tO\nWe\tO\n're\tO\nused\tO\nto\tO\nhearing\tO\nthe\tO\ntaunts\tO\nof\tO\n\"\tO\nDeath\tO\nto\tO\nthe\tO\nArabs\tO\n'\tO\n,\tO\n\"\tO\nsaid\tT-1\nSameh\tO\nHaj\tO\nYihye\tO\n,\tO\na\tO\nTaibe\tB-LOC\nresident\tT-0\nwho\tO\nstudies\tO\nat\tO\nJerusalem\tO\n's\tO\nHebrew\tO\nUniversity\tO\n.\tO\n\"\tO\n\n\"\tO\nWe\tO\n're\tO\nused\tT-1\nto\tO\nhearing\tO\nthe\tO\ntaunts\tO\nof\tO\n\"\tO\nDeath\tO\nto\tO\nthe\tO\nArabs\tO\n'\tO\n,\tO\n\"\tO\nsaid\tO\nSameh\tO\nHaj\tO\nYihye\tO\n,\tO\na\tO\nTaibe\tT-2\nresident\tT-2\nwho\tT-0\nstudies\tT-0\nat\tT-0\nJerusalem\tB-LOC\n's\tO\nHebrew\tO\nUniversity\tO\n.\tO\n\"\tO\n\n\"\tO\nWe\tO\n're\tO\nused\tO\nto\tO\nhearing\tO\nthe\tO\ntaunts\tT-1\nof\tO\n\"\tO\nDeath\tO\nto\tO\nthe\tO\nArabs\tO\n'\tO\n,\tO\n\"\tO\nsaid\tO\nSameh\tO\nHaj\tO\nYihye\tO\n,\tO\na\tO\nTaibe\tO\nresident\tO\nwho\tO\nstudies\tT-0\nat\tO\nJerusalem\tO\n's\tO\nHebrew\tB-ORG\nUniversity\tI-ORG\n.\tO\n\"\tO\n\nThe\tO\ndusty\tT-2\ntown\tT-2\nof\tO\nTaibe\tB-LOC\nlacks\tT-1\nthe\tO\namenities\tO\nof\tO\nJewish\tO\ncommunities\tO\nand\tO\nmany\tO\nIsraeli\tO\nArabs\tO\nhave\tO\nlong\tO\ncomplained\tT-0\nof\tO\nstate\tO\ndiscrimination\tT-3\n.\tO\n\nThe\tO\ndusty\tO\ntown\tT-2\nof\tT-2\nTaibe\tT-2\nlacks\tT-0\nthe\tO\namenities\tO\nof\tO\nJewish\tB-MISC\ncommunities\tT-1\nand\tO\nmany\tO\nIsraeli\tO\nArabs\tO\nhave\tO\nlong\tO\ncomplained\tO\nof\tO\nstate\tO\ndiscrimination\tO\n.\tO\n\nThe\tO\ndusty\tO\ntown\tO\nof\tO\nTaibe\tO\nlacks\tO\nthe\tO\namenities\tT-2\nof\tO\nJewish\tO\ncommunities\tO\nand\tO\nmany\tO\nIsraeli\tB-MISC\nArabs\tI-MISC\nhave\tO\nlong\tO\ncomplained\tT-0\nof\tO\nstate\tO\ndiscrimination\tT-1\n.\tO\n\n\"\tO\nThere\tO\nare\tO\nno\tO\nparks\tO\nor\tO\nempty\tT-1\nareas\tT-1\nof\tO\nland\tO\naround\tO\nhere\tO\n,\tO\nso\tO\nwhen\tO\nwe\tO\nwant\tO\nto\tO\nplay\tO\na\tO\nfriendly\tO\ngame\tT-2\nof\tT-2\nsoccer\tT-2\nwe\tO\nall\tO\nload\tO\nup\tO\nin\tO\nthe\tO\ncar\tO\nand\tO\ntravel\tO\nto\tT-0\nTel\tB-LOC\nAviv\tI-LOC\n,\tO\n\"\tO\n60\tT-3\nkm\tT-3\n(\tT-3\n36\tT-3\nmiles\tT-3\n)\tT-3\naway\tT-3\n,\tO\nSameh\tO\nHaj\tO\nYihye\tO\nsaid\tO\n.\tO\n\n\"\tO\nWe\tO\nplan\tO\nto\tT-1\nbuild\tT-1\na\tO\n10,000-seat\tO\nstadium\tT-2\n,\tO\nbut\tO\nit\tO\nmay\tO\nwell\tO\nbe\tO\nsituated\tO\nelsewhere\tO\n,\tO\n\"\tO\nsaid\tO\nclub\tO\nchairman\tT-0\nAbdul\tB-PER\nRahman\tI-PER\nHaj\tI-PER\nYihye\tI-PER\n.\tO\n\"\tO\n\nIn\tO\nthe\tO\nmeantime\tO\n,\tO\nTaibe\tB-ORG\nwill\tT-1\nplay\tT-2\nall\tO\ntheir\tO\nheavily\tO\npoliced\tO\nhome\tO\nmatches\tT-3\nat\tT-0\nthe\tO\nJewish\tO\ncoastal\tO\ntown\tO\nof\tO\nNetanya\tT-4\n.\tT-4\n\nIn\tO\nthe\tO\nmeantime\tO\n,\tO\nTaibe\tT-2\nwill\tO\nplay\tO\nall\tO\ntheir\tO\nheavily\tO\npoliced\tO\nhome\tO\nmatches\tT-0\nat\tO\nthe\tO\nJewish\tB-MISC\ncoastal\tT-1\ntown\tO\nof\tO\nNetanya\tO\n.\tO\n\nIn\tO\nthe\tO\nmeantime\tO\n,\tO\nTaibe\tO\nwill\tO\nplay\tT-1\nall\tO\ntheir\tO\nheavily\tO\npoliced\tO\nhome\tT-0\nmatches\tT-0\nat\tO\nthe\tO\nJewish\tT-2\ncoastal\tT-2\ntown\tO\nof\tO\nNetanya\tB-LOC\n.\tO\n\n\"\tO\nWe\tO\nare\tT-0\nIsraelis\tB-MISC\n,\tO\nthere\tO\nis\tO\nno\tO\nquestion\tO\nabout\tO\nthat\tO\n,\tO\n\"\tO\nsaid\tO\nKarem\tT-2\nHaj\tT-2\nYihye\tT-2\n,\tO\na\tO\nhotel\tT-1\nwaiter\tT-1\n.\tO\n\n\"\tO\nWe\tO\nare\tO\nIsraelis\tO\n,\tO\nthere\tO\nis\tO\nno\tO\nquestion\tO\nabout\tO\nthat\tO\n,\tO\n\"\tO\nsaid\tT-0\nKarem\tB-PER\nHaj\tI-PER\nYihye\tI-PER\n,\tO\na\tO\nhotel\tT-1\nwaiter\tT-1\n.\tO\n\n\"\tO\nWe\tO\ndo\tO\nn't\tO\nhave\tO\nany\tO\nconnection\tT-0\nwith\tO\nthe\tO\nPalestinians\tB-MISC\n,\tO\nthey\tO\nlive\tT-3\nover\tO\nthere\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tT-1\n,\tO\npointing\tT-2\nto\tO\nthe\tO\nWest\tT-4\nBank\tT-4\nseven\tO\nkm\tO\n(\tO\nfour\tO\nmiles\tO\n)\tO\nto\tO\nthe\tO\neast\tO\n.\tO\n\n\"\tO\nWe\tO\ndo\tO\nn't\tO\nhave\tO\nany\tO\nconnection\tO\nwith\tO\nthe\tO\nPalestinians\tT-1\n,\tO\nthey\tO\nlive\tO\nover\tT-2\nthere\tT-2\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n,\tO\npointing\tT-0\nto\tT-0\nthe\tT-0\nWest\tB-LOC\nBank\tI-LOC\nseven\tO\nkm\tO\n(\tO\nfour\tO\nmiles\tO\n)\tO\nto\tO\nthe\tO\neast\tT-3\n.\tO\n\n\"\tO\nWe\tO\ndo\tO\nn't\tO\nfeel\tO\nour\tO\nclub\tO\nrepresents\tT-2\nPalestinian\tO\nArabs\tO\n,\tO\n\"\tO\nsaid\tO\nclub\tT-0\nchairman\tT-1\nAbdul\tB-PER\nRahman\tI-PER\n.\tO\n\"\tO\n\nWe\tO\nare\tO\ntrying\tO\nto\tO\ndo\tO\nall\tO\nwe\tO\ncan\tO\nto\tO\nrun\tO\na\tO\nprofessional\tO\noutfit\tO\n,\tO\nwe\tO\nare\tO\npleased\tO\nat\tO\nany\tO\nsupport\tO\nwe\tO\nget\tO\n,\tO\nbut\tO\ndo\tO\nnot\tO\ngo\tO\nout\tO\nlooking\tO\nto\tO\nrepresent\tT-2\nthe\tT-1\nwhole\tT-1\nArab\tB-MISC\nworld\tT-0\n.\tO\n\"\tO\n\nSoccer\tT-2\n-\tO\nKennedy\tB-PER\nand\tT-0\nPhelan\tO\nboth\tT-1\nout\tT-1\nof\tT-1\nIrish\tO\nsquad\tO\n.\tO\n\nSoccer\tO\n-\tO\nKennedy\tO\nand\tO\nPhelan\tB-PER\nboth\tO\nout\tT-0\nof\tT-0\nIrish\tT-2\nsquad\tT-1\n.\tO\n\nSoccer\tT-2\n-\tO\nKennedy\tT-0\nand\tO\nPhelan\tT-1\nboth\tO\nout\tO\nof\tO\nIrish\tB-MISC\nsquad\tO\n.\tO\n\nTwo\tO\nplayers\tO\nhave\tO\nwithdrawn\tT-1\nfrom\tO\nthe\tO\nRepublic\tB-LOC\nof\tI-LOC\nIreland\tI-LOC\nsquad\tT-0\nfor\tO\nthe\tO\n1998\tO\nWorld\tO\nCup\tO\nqualifying\tO\nmatch\tO\nagainst\tO\nLiechenstein\tO\non\tO\nAugust\tO\n31\tO\n,\tO\nthe\tO\nFootball\tO\nAssociation\tO\nof\tO\nIreland\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\non\tO\nFriday\tO\n.\tO\n\nTwo\tO\nplayers\tO\nhave\tO\nwithdrawn\tT-1\nfrom\tO\nthe\tO\nRepublic\tT-2\nof\tT-2\nIreland\tT-2\nsquad\tT-2\nfor\tO\nthe\tO\n1998\tO\nWorld\tB-MISC\nCup\tI-MISC\nqualifying\tT-0\nmatch\tO\nagainst\tO\nLiechenstein\tO\non\tO\nAugust\tO\n31\tO\n,\tO\nthe\tO\nFootball\tO\nAssociation\tO\nof\tO\nIreland\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\non\tO\nFriday\tO\n.\tO\n\nTwo\tO\nplayers\tO\nhave\tO\nwithdrawn\tO\nfrom\tO\nthe\tO\nRepublic\tO\nof\tO\nIreland\tO\nsquad\tO\nfor\tO\nthe\tO\n1998\tO\nWorld\tO\nCup\tO\nqualifying\tO\nmatch\tO\nagainst\tT-0\nLiechenstein\tB-LOC\non\tO\nAugust\tO\n31\tO\n,\tO\nthe\tO\nFootball\tO\nAssociation\tO\nof\tO\nIreland\tO\nsaid\tO\nin\tO\na\tO\nstatement\tT-1\non\tO\nFriday\tO\n.\tO\n\nTwo\tO\nplayers\tO\nhave\tO\nwithdrawn\tO\nfrom\tO\nthe\tO\nRepublic\tO\nof\tO\nIreland\tO\nsquad\tO\nfor\tO\nthe\tO\n1998\tO\nWorld\tO\nCup\tO\nqualifying\tO\nmatch\tO\nagainst\tO\nLiechenstein\tO\non\tO\nAugust\tO\n31\tO\n,\tO\nthe\tT-1\nFootball\tB-ORG\nAssociation\tI-ORG\nof\tI-ORG\nIreland\tI-ORG\nsaid\tT-0\nin\tO\na\tO\nstatement\tO\non\tO\nFriday\tO\n.\tO\n\nThe\tT-5\nF.A.I.\tB-ORG\nstatement\tT-6\nsaid\tT-3\nthat\tO\nLiverpool\tT-0\nstriker\tT-0\nMark\tO\nKennedy\tT-4\nand\tO\nChelsea\tT-1\ndefender\tT-1\nTerry\tO\nPhelan\tO\nwere\tO\nboth\tO\nreceiving\tO\ntreatment\tO\nfor\tO\ninjuries\tO\nand\tO\nwould\tO\nnot\tO\nbe\tO\ntravelling\tO\nto\tO\nLiechenstein\tO\nfor\tO\nthe\tO\ngame\tT-2\n.\tO\n\nThe\tO\nF.A.I.\tT-1\nstatement\tT-0\nsaid\tO\nthat\tO\nLiverpool\tB-ORG\nstriker\tO\nMark\tT-2\nKennedy\tT-2\nand\tO\nChelsea\tT-3\ndefender\tO\nTerry\tT-4\nPhelan\tT-4\nwere\tO\nboth\tO\nreceiving\tO\ntreatment\tO\nfor\tO\ninjuries\tO\nand\tO\nwould\tO\nnot\tO\nbe\tO\ntravelling\tO\nto\tO\nLiechenstein\tO\nfor\tO\nthe\tO\ngame\tO\n.\tO\n\nThe\tO\nF.A.I.\tO\nstatement\tO\nsaid\tO\nthat\tO\nLiverpool\tO\nstriker\tT-0\nMark\tB-PER\nKennedy\tI-PER\nand\tO\nChelsea\tO\ndefender\tO\nTerry\tT-2\nPhelan\tT-2\nwere\tO\nboth\tO\nreceiving\tT-1\ntreatment\tT-1\nfor\tT-1\ninjuries\tT-1\nand\tO\nwould\tO\nnot\tO\nbe\tO\ntravelling\tO\nto\tO\nLiechenstein\tO\nfor\tO\nthe\tO\ngame\tO\n.\tO\n\nThe\tO\nF.A.I.\tO\nstatement\tO\nsaid\tT-3\nthat\tO\nLiverpool\tT-0\nstriker\tO\nMark\tO\nKennedy\tO\nand\tO\nChelsea\tB-ORG\ndefender\tT-1\nTerry\tO\nPhelan\tO\nwere\tO\nboth\tO\nreceiving\tO\ntreatment\tO\nfor\tO\ninjuries\tO\nand\tO\nwould\tO\nnot\tO\nbe\tO\ntravelling\tO\nto\tO\nLiechenstein\tO\nfor\tO\nthe\tO\ngame\tT-2\n.\tO\n\nThe\tO\nF.A.I.\tO\nstatement\tO\nsaid\tT-0\nthat\tO\nLiverpool\tO\nstriker\tO\nMark\tO\nKennedy\tO\nand\tO\nChelsea\tO\ndefender\tO\nTerry\tB-PER\nPhelan\tI-PER\nwere\tO\nboth\tO\nreceiving\tT-2\ntreatment\tO\nfor\tO\ninjuries\tO\nand\tO\nwould\tO\nnot\tO\nbe\tO\ntravelling\tO\nto\tO\nLiechenstein\tT-1\nfor\tO\nthe\tO\ngame\tO\n.\tO\n\nThe\tO\nF.A.I.\tO\nstatement\tO\nsaid\tT-1\nthat\tO\nLiverpool\tT-2\nstriker\tO\nMark\tO\nKennedy\tO\nand\tO\nChelsea\tO\ndefender\tO\nTerry\tO\nPhelan\tO\nwere\tO\nboth\tO\nreceiving\tO\ntreatment\tO\nfor\tO\ninjuries\tO\nand\tO\nwould\tO\nnot\tO\nbe\tO\ntravelling\tT-0\nto\tO\nLiechenstein\tB-LOC\nfor\tO\nthe\tT-3\ngame\tT-3\n.\tO\n\n--\tO\nDamien\tB-PER\nLynch\tI-PER\n,\tO\nDublin\tO\nNewsroom\tO\n+353\tT-0\n1\tT-0\n6603377\tT-0\n\nSoccer\tT-0\n-\tO\nManchester\tB-ORG\nUnited\tI-ORG\nface\tT-2\nJuventus\tO\nin\tT-1\nEurope\tO\n.\tO\n\nSoccer\tO\n-\tO\nManchester\tO\nUnited\tO\nface\tT-0\nJuventus\tB-ORG\nin\tO\nEurope\tT-1\n.\tO\n\nSoccer\tO\n-\tO\nManchester\tT-0\nUnited\tT-0\nface\tO\nJuventus\tO\nin\tO\nEurope\tB-LOC\n.\tO\n\nEuropean\tB-MISC\nchampions\tT-0\nJuventus\tO\nwill\tO\nface\tT-1\nEnglish\tO\nleague\tO\nand\tO\ncup\tO\ndouble\tO\nwinners\tO\nManchester\tO\nUnited\tO\nin\tO\nthis\tO\nseason\tO\n's\tO\nEuropean\tT-2\nChampions\tT-2\n'\tT-2\nLeague\tT-2\n.\tO\n\nEuropean\tO\nchampions\tT-1\nJuventus\tB-ORG\nwill\tO\nface\tO\nEnglish\tO\nleague\tO\nand\tO\ncup\tO\ndouble\tO\nwinners\tO\nManchester\tO\nUnited\tO\nin\tO\nthis\tO\nseason\tO\n's\tO\nEuropean\tO\nChampions\tT-0\n'\tO\nLeague\tO\n.\tO\n\nEuropean\tT-3\nchampions\tT-3\nJuventus\tT-0\nwill\tO\nface\tT-1\nEnglish\tB-MISC\nleague\tT-2\nand\tO\ncup\tO\ndouble\tO\nwinners\tO\nManchester\tO\nUnited\tO\nin\tO\nthis\tO\nseason\tO\n's\tO\nEuropean\tO\nChampions\tO\n'\tO\nLeague\tO\n.\tO\n\nEuropean\tO\nchampions\tO\nJuventus\tT-1\nwill\tO\nface\tO\nEnglish\tO\nleague\tO\nand\tO\ncup\tO\ndouble\tO\nwinners\tT-2\nManchester\tB-ORG\nUnited\tI-ORG\nin\tO\nthis\tT-0\nseason\tT-0\n's\tT-0\nEuropean\tO\nChampions\tO\n'\tO\nLeague\tO\n.\tO\n\nEuropean\tO\nchampions\tT-0\nJuventus\tO\nwill\tO\nface\tO\nEnglish\tO\nleague\tO\nand\tO\ncup\tO\ndouble\tO\nwinners\tO\nManchester\tT-1\nUnited\tO\nin\tO\nthis\tO\nseason\tT-2\n's\tO\nEuropean\tB-MISC\nChampions\tI-MISC\n'\tI-MISC\nLeague\tI-MISC\n.\tO\n\nThe\tO\ndraw\tT-2\nmade\tT-3\non\tO\nFriday\tO\npitted\tT-1\nJuventus\tB-ORG\n,\tO\nwho\tO\nbeat\tT-4\nDutch\tO\nchampions\tT-0\nAjax\tO\nAmsterdam\tO\n4-2\tO\non\tO\npenalties\tO\nin\tO\nlast\tO\nyear\tO\n's\tO\nfinal\tO\n,\tO\nagainst\tO\nAlex\tO\nFerguson\tO\n's\tO\nEuropean\tO\nhopefuls\tO\nin\tO\ngroup\tO\nC\tO\n.\tO\n\nThe\tO\ndraw\tO\nmade\tT-1\non\tO\nFriday\tO\npitted\tO\nJuventus\tO\n,\tO\nwho\tO\nbeat\tT-2\nDutch\tB-MISC\nchampions\tT-0\nAjax\tO\nAmsterdam\tO\n4-2\tO\non\tO\npenalties\tO\nin\tO\nlast\tO\nyear\tO\n's\tO\nfinal\tO\n,\tO\nagainst\tO\nAlex\tO\nFerguson\tO\n's\tO\nEuropean\tO\nhopefuls\tO\nin\tO\ngroup\tO\nC\tO\n.\tO\n\nThe\tO\ndraw\tO\nmade\tO\non\tO\nFriday\tO\npitted\tO\nJuventus\tO\n,\tO\nwho\tO\nbeat\tO\nDutch\tO\nchampions\tT-1\nAjax\tB-ORG\nAmsterdam\tI-ORG\n4-2\tO\non\tO\npenalties\tO\nin\tO\nlast\tO\nyear\tO\n's\tO\nfinal\tO\n,\tO\nagainst\tO\nAlex\tO\nFerguson\tO\n's\tO\nEuropean\tT-0\nhopefuls\tO\nin\tO\ngroup\tO\nC\tO\n.\tO\n\nThe\tO\ndraw\tO\nmade\tO\non\tO\nFriday\tO\npitted\tO\nJuventus\tO\n,\tO\nwho\tT-1\nbeat\tO\nDutch\tO\nchampions\tO\nAjax\tO\nAmsterdam\tO\n4-2\tO\non\tO\npenalties\tO\nin\tO\nlast\tO\nyear\tO\n's\tO\nfinal\tO\n,\tO\nagainst\tT-0\nAlex\tB-PER\nFerguson\tI-PER\n's\tO\nEuropean\tO\nhopefuls\tO\nin\tO\ngroup\tO\nC\tO\n.\tO\n\nThe\tO\ndraw\tO\nmade\tO\non\tO\nFriday\tO\npitted\tO\nJuventus\tO\n,\tO\nwho\tO\nbeat\tO\nDutch\tO\nchampions\tO\nAjax\tO\nAmsterdam\tO\n4-2\tO\non\tO\npenalties\tO\nin\tO\nlast\tO\nyear\tO\n's\tO\nfinal\tO\n,\tO\nagainst\tO\nAlex\tO\nFerguson\tT-1\n's\tO\nEuropean\tB-MISC\nhopefuls\tT-0\nin\tO\ngroup\tO\nC\tO\n.\tO\n\nThe\tO\nother\tO\ntwo\tT-3\nteams\tT-3\nin\tO\nthe\tO\ngroup\tO\nare\tO\nlast\tT-4\nseason\tT-4\n's\tT-4\nCup\tB-MISC\nWinners\tI-MISC\n'\tI-MISC\nCup\tI-MISC\nrunners-up\tT-2\nRapid\tT-0\nVienna\tT-0\nand\tO\nFenerbahce\tT-5\nof\tO\nTurkey\tO\n.\tO\n\nThe\tO\nother\tO\ntwo\tO\nteams\tO\nin\tO\nthe\tO\ngroup\tO\nare\tO\nlast\tT-2\nseason\tO\n's\tO\nCup\tT-0\nWinners\tT-0\n'\tT-0\nCup\tT-1\nrunners-up\tT-1\nRapid\tB-ORG\nVienna\tI-ORG\nand\tO\nFenerbahce\tT-3\nof\tO\nTurkey\tO\n.\tO\n\nThe\tO\nother\tO\ntwo\tO\nteams\tO\nin\tO\nthe\tO\ngroup\tO\nare\tO\nlast\tO\nseason\tT-1\n's\tT-1\nCup\tT-1\nWinners\tT-1\n'\tO\nCup\tO\nrunners-up\tO\nRapid\tT-2\nVienna\tT-2\nand\tO\nFenerbahce\tB-ORG\nof\tO\nTurkey\tO\n.\tO\n\nThe\tO\nother\tO\ntwo\tO\nteams\tO\nin\tO\nthe\tO\ngroup\tO\nare\tO\nlast\tO\nseason\tO\n's\tO\nCup\tO\nWinners\tT-3\n'\tO\nCup\tO\nrunners-up\tT-0\nRapid\tO\nVienna\tT-1\nand\tO\nFenerbahce\tT-2\nof\tO\nTurkey\tB-LOC\n.\tO\n\nJuventus\tB-ORG\nmeet\tO\nUnited\tO\nin\tO\nTurin\tT-0\non\tO\nSeptember\tO\n11\tO\n,\tO\nwith\tO\nthe\tO\nreturn\tO\nmatch\tO\nat\tO\nOld\tO\nTrafford\tO\non\tO\nNovember\tO\n20\tO\n.\tO\n\nJuventus\tT-0\nmeet\tT-0\nUnited\tB-ORG\nin\tO\nTurin\tO\non\tO\nSeptember\tO\n11\tO\n,\tO\nwith\tO\nthe\tO\nreturn\tO\nmatch\tO\nat\tO\nOld\tO\nTrafford\tO\non\tO\nNovember\tO\n20\tO\n.\tO\n\nJuventus\tO\nmeet\tO\nUnited\tT-1\nin\tT-0\nTurin\tB-LOC\non\tO\nSeptember\tO\n11\tO\n,\tO\nwith\tO\nthe\tO\nreturn\tO\nmatch\tO\nat\tO\nOld\tO\nTrafford\tO\non\tO\nNovember\tO\n20\tO\n.\tO\n\nJuventus\tT-1\nmeet\tO\nUnited\tO\nin\tT-0\nTurin\tO\non\tO\nSeptember\tO\n11\tO\n,\tO\nwith\tO\nthe\tO\nreturn\tO\nmatch\tO\nat\tO\nOld\tB-LOC\nTrafford\tI-LOC\non\tO\nNovember\tO\n20\tO\n.\tO\n\nUnited\tB-ORG\nhave\tO\ndominated\tT-0\nthe\tO\npremier\tT-2\nleague\tT-2\nin\tO\nthe\tO\n1990s\tO\n,\tO\nwinning\tO\nthree\tO\nEnglish\tO\nchampionships\tO\nin\tO\nfour\tO\nyears\tO\n,\tO\nbut\tO\nhave\tO\nconsistently\tO\nfailed\tT-1\nin\tO\nEurope\tO\n,\tO\ncrashing\tO\nout\tO\nof\tO\nthe\tO\nEuropean\tO\nCup\tO\nto\tO\nGalatasaray\tO\nof\tO\nTurkey\tO\nand\tO\nSpain\tO\n's\tO\nBarcelona\tO\nat\tO\ntheir\tO\nlast\tO\ntwo\tO\nattempts\tO\n.\tO\n\nUnited\tO\nhave\tO\ndominated\tT-1\nthe\tO\npremier\tO\nleague\tO\nin\tO\nthe\tO\n1990s\tO\n,\tO\nwinning\tO\nthree\tO\nEnglish\tB-MISC\nchampionships\tT-0\nin\tO\nfour\tO\nyears\tO\n,\tO\nbut\tO\nhave\tO\nconsistently\tO\nfailed\tT-2\nin\tO\nEurope\tO\n,\tO\ncrashing\tO\nout\tO\nof\tO\nthe\tO\nEuropean\tT-4\nCup\tT-4\nto\tO\nGalatasaray\tO\nof\tO\nTurkey\tO\nand\tO\nSpain\tO\n's\tO\nBarcelona\tO\nat\tO\ntheir\tO\nlast\tO\ntwo\tT-3\nattempts\tT-3\n.\tO\n\nUnited\tO\nhave\tO\ndominated\tT-1\nthe\tO\npremier\tT-2\nleague\tT-2\nin\tO\nthe\tO\n1990s\tO\n,\tO\nwinning\tO\nthree\tO\nEnglish\tT-0\nchampionships\tT-0\nin\tO\nfour\tO\nyears\tO\n,\tO\nbut\tO\nhave\tO\nconsistently\tO\nfailed\tT-3\nin\tO\nEurope\tB-LOC\n,\tO\ncrashing\tO\nout\tO\nof\tO\nthe\tO\nEuropean\tT-5\nCup\tT-5\nto\tO\nGalatasaray\tO\nof\tO\nTurkey\tO\nand\tO\nSpain\tO\n's\tO\nBarcelona\tO\nat\tO\ntheir\tO\nlast\tO\ntwo\tT-4\nattempts\tT-4\n.\tO\n\nUnited\tO\nhave\tO\ndominated\tO\nthe\tO\npremier\tO\nleague\tO\nin\tO\nthe\tO\n1990s\tO\n,\tO\nwinning\tO\nthree\tO\nEnglish\tO\nchampionships\tO\nin\tO\nfour\tO\nyears\tO\n,\tO\nbut\tO\nhave\tO\nconsistently\tO\nfailed\tO\nin\tO\nEurope\tO\n,\tO\ncrashing\tT-4\nout\tO\nof\tO\nthe\tO\nEuropean\tB-MISC\nCup\tI-MISC\nto\tO\nGalatasaray\tT-0\nof\tO\nTurkey\tT-1\nand\tO\nSpain\tT-2\n's\tO\nBarcelona\tT-3\nat\tO\ntheir\tO\nlast\tO\ntwo\tO\nattempts\tO\n.\tO\n\nUnited\tO\nhave\tO\ndominated\tT-0\nthe\tO\npremier\tT-1\nleague\tT-1\nin\tO\nthe\tO\n1990s\tO\n,\tO\nwinning\tO\nthree\tO\nEnglish\tO\nchampionships\tO\nin\tO\nfour\tO\nyears\tO\n,\tO\nbut\tO\nhave\tO\nconsistently\tO\nfailed\tT-2\nin\tO\nEurope\tO\n,\tO\ncrashing\tO\nout\tO\nof\tO\nthe\tO\nEuropean\tO\nCup\tO\nto\tO\nGalatasaray\tB-ORG\nof\tO\nTurkey\tO\nand\tO\nSpain\tO\n's\tO\nBarcelona\tO\nat\tO\ntheir\tO\nlast\tO\ntwo\tO\nattempts\tO\n.\tO\n\nUnited\tO\nhave\tO\ndominated\tO\nthe\tO\npremier\tO\nleague\tO\nin\tO\nthe\tO\n1990s\tO\n,\tO\nwinning\tO\nthree\tO\nEnglish\tO\nchampionships\tO\nin\tO\nfour\tO\nyears\tO\n,\tO\nbut\tO\nhave\tO\nconsistently\tO\nfailed\tT-2\nin\tO\nEurope\tO\n,\tO\ncrashing\tO\nout\tO\nof\tO\nthe\tO\nEuropean\tO\nCup\tO\nto\tO\nGalatasaray\tT-0\nof\tO\nTurkey\tB-LOC\nand\tO\nSpain\tO\n's\tO\nBarcelona\tT-1\nat\tO\ntheir\tO\nlast\tO\ntwo\tO\nattempts\tO\n.\tO\n\nUnited\tO\nhave\tO\ndominated\tT-1\nthe\tO\npremier\tO\nleague\tO\nin\tO\nthe\tO\n1990s\tO\n,\tO\nwinning\tO\nthree\tO\nEnglish\tO\nchampionships\tO\nin\tO\nfour\tO\nyears\tO\n,\tO\nbut\tO\nhave\tO\nconsistently\tO\nfailed\tO\nin\tO\nEurope\tO\n,\tO\ncrashing\tO\nout\tO\nof\tO\nthe\tO\nEuropean\tO\nCup\tO\nto\tO\nGalatasaray\tO\nof\tO\nTurkey\tT-0\nand\tO\nSpain\tB-LOC\n's\tO\nBarcelona\tO\nat\tO\ntheir\tO\nlast\tO\ntwo\tO\nattempts\tO\n.\tO\n\nUnited\tO\nhave\tO\ndominated\tT-0\nthe\tO\npremier\tT-2\nleague\tT-2\nin\tO\nthe\tO\n1990s\tO\n,\tO\nwinning\tO\nthree\tO\nEnglish\tT-3\nchampionships\tT-3\nin\tO\nfour\tO\nyears\tO\n,\tO\nbut\tO\nhave\tO\nconsistently\tO\nfailed\tT-1\nin\tO\nEurope\tO\n,\tO\ncrashing\tO\nout\tO\nof\tO\nthe\tO\nEuropean\tT-4\nCup\tT-4\nto\tO\nGalatasaray\tO\nof\tO\nTurkey\tO\nand\tO\nSpain\tO\n's\tO\nBarcelona\tB-ORG\nat\tO\ntheir\tO\nlast\tO\ntwo\tO\nattempts\tO\n.\tO\n\nThey\tO\nhave\tO\nnot\tO\nlifted\tT-0\na\tO\nEuropean\tB-MISC\nTrophy\tI-MISC\nsince\tO\n1991\tO\nwhen\tO\nthey\tO\nbeat\tT-1\nBarcelona\tO\nin\tO\nthe\tO\nCup\tO\nWinners\tO\n'\tO\nCup\tO\nfinal\tO\n,\tO\nand\tO\ntheir\tO\none\tO\nand\tO\nonly\tO\nEuropean\tO\nCup\tO\ntriumph\tO\nwas\tO\nway\tO\nback\tO\nin\tO\n1968\tO\n,\tO\nwhen\tO\nthey\tO\nbeat\tO\nBenfica\tO\nof\tO\nPortugal\tO\n4-1\tO\nat\tO\nWembley\tO\n.\tO\n\nThey\tO\nhave\tO\nnot\tO\nlifted\tT-3\na\tO\nEuropean\tO\nTrophy\tO\nsince\tO\n1991\tT-0\nwhen\tO\nthey\tO\nbeat\tT-1\nBarcelona\tB-ORG\nin\tO\nthe\tO\nCup\tO\nWinners\tT-2\n'\tT-2\nCup\tT-2\nfinal\tO\n,\tO\nand\tO\ntheir\tO\none\tO\nand\tO\nonly\tO\nEuropean\tO\nCup\tO\ntriumph\tT-4\nwas\tO\nway\tO\nback\tO\nin\tO\n1968\tO\n,\tO\nwhen\tO\nthey\tO\nbeat\tO\nBenfica\tO\nof\tO\nPortugal\tO\n4-1\tO\nat\tO\nWembley\tO\n.\tO\n\nThey\tO\nhave\tO\nnot\tO\nlifted\tT-3\na\tO\nEuropean\tO\nTrophy\tO\nsince\tO\n1991\tO\nwhen\tO\nthey\tO\nbeat\tT-1\nBarcelona\tT-0\nin\tO\nthe\tO\nCup\tB-MISC\nWinners\tI-MISC\n'\tI-MISC\nCup\tI-MISC\nfinal\tO\n,\tO\nand\tO\ntheir\tO\none\tO\nand\tO\nonly\tO\nEuropean\tO\nCup\tO\ntriumph\tT-2\nwas\tO\nway\tO\nback\tO\nin\tO\n1968\tO\n,\tO\nwhen\tO\nthey\tO\nbeat\tO\nBenfica\tO\nof\tO\nPortugal\tO\n4-1\tO\nat\tO\nWembley\tO\n.\tO\n\nThey\tO\nhave\tO\nnot\tO\nlifted\tT-1\na\tO\nEuropean\tT-0\nTrophy\tO\nsince\tO\n1991\tO\nwhen\tO\nthey\tO\nbeat\tO\nBarcelona\tO\nin\tO\nthe\tO\nCup\tO\nWinners\tO\n'\tO\nCup\tT-2\nfinal\tT-2\n,\tO\nand\tO\ntheir\tO\none\tO\nand\tO\nonly\tO\nEuropean\tB-MISC\nCup\tI-MISC\ntriumph\tO\nwas\tO\nway\tO\nback\tO\nin\tO\n1968\tO\n,\tO\nwhen\tO\nthey\tO\nbeat\tO\nBenfica\tO\nof\tO\nPortugal\tO\n4-1\tO\nat\tO\nWembley\tO\n.\tO\n\nThey\tO\nhave\tO\nnot\tO\nlifted\tO\na\tO\nEuropean\tT-2\nTrophy\tT-2\nsince\tO\n1991\tO\nwhen\tO\nthey\tO\nbeat\tT-0\nBarcelona\tO\nin\tO\nthe\tO\nCup\tO\nWinners\tO\n'\tO\nCup\tO\nfinal\tO\n,\tO\nand\tO\ntheir\tO\none\tO\nand\tO\nonly\tO\nEuropean\tT-1\nCup\tT-1\ntriumph\tO\nwas\tO\nway\tO\nback\tO\nin\tO\n1968\tO\n,\tO\nwhen\tO\nthey\tO\nbeat\tT-3\nBenfica\tB-ORG\nof\tT-4\nPortugal\tO\n4-1\tO\nat\tO\nWembley\tO\n.\tO\n\nThey\tO\nhave\tO\nnot\tO\nlifted\tT-0\na\tO\nEuropean\tO\nTrophy\tO\nsince\tO\n1991\tO\nwhen\tO\nthey\tO\nbeat\tO\nBarcelona\tO\nin\tO\nthe\tO\nCup\tO\nWinners\tO\n'\tO\nCup\tO\nfinal\tO\n,\tO\nand\tO\ntheir\tO\none\tO\nand\tO\nonly\tO\nEuropean\tO\nCup\tO\ntriumph\tO\nwas\tO\nway\tO\nback\tO\nin\tO\n1968\tO\n,\tO\nwhen\tO\nthey\tO\nbeat\tT-1\nBenfica\tO\nof\tO\nPortugal\tB-LOC\n4-1\tO\nat\tO\nWembley\tO\n.\tO\n\nThey\tO\nhave\tO\nnot\tO\nlifted\tO\na\tO\nEuropean\tO\nTrophy\tO\nsince\tO\n1991\tO\nwhen\tO\nthey\tO\nbeat\tO\nBarcelona\tT-0\nin\tO\nthe\tO\nCup\tO\nWinners\tO\n'\tO\nCup\tT-2\nfinal\tT-2\n,\tO\nand\tO\ntheir\tO\none\tO\nand\tO\nonly\tO\nEuropean\tO\nCup\tO\ntriumph\tO\nwas\tO\nway\tO\nback\tO\nin\tO\n1968\tO\n,\tO\nwhen\tO\nthey\tO\nbeat\tO\nBenfica\tO\nof\tO\nPortugal\tT-1\n4-1\tO\nat\tO\nWembley\tB-LOC\n.\tO\n\nJuventus\tB-ORG\nhave\tO\nwon\tO\nthe\tO\nEuropean\tT-0\nCup\tO\ntwice\tO\n.\tO\n\nJuventus\tT-0\nhave\tO\nwon\tO\nthe\tO\nEuropean\tB-MISC\nCup\tI-MISC\ntwice\tO\n.\tO\n\nBefore\tO\nconquering\tT-2\nAjax\tB-ORG\nlast\tO\nyear\tO\nthey\tO\nbeat\tO\nUnited\tO\n's\tO\nbig\tO\nEnglish\tO\nrivals\tO\nLiverpool\tO\nin\tO\nthe\tO\nill-fated\tO\n1985\tO\nfinal\tO\nin\tO\nthe\tO\nHeysel\tT-0\nstadium\tO\nin\tO\nBrussels\tT-1\n.\tO\n\nBefore\tO\nconquering\tO\nAjax\tT-1\nlast\tO\nyear\tO\nthey\tT-0\nbeat\tT-3\nUnited\tB-ORG\n's\tO\nbig\tO\nEnglish\tT-2\nrivals\tT-2\nLiverpool\tO\nin\tO\nthe\tO\nill-fated\tO\n1985\tO\nfinal\tO\nin\tO\nthe\tO\nHeysel\tO\nstadium\tO\nin\tO\nBrussels\tO\n.\tO\n\nBefore\tO\nconquering\tT-1\nAjax\tO\nlast\tO\nyear\tO\nthey\tO\nbeat\tT-2\nUnited\tT-0\n's\tT-0\nbig\tT-0\nEnglish\tB-MISC\nrivals\tO\nLiverpool\tO\nin\tO\nthe\tO\nill-fated\tO\n1985\tO\nfinal\tO\nin\tO\nthe\tO\nHeysel\tO\nstadium\tO\nin\tO\nBrussels\tO\n.\tO\n\nBefore\tO\nconquering\tT-1\nAjax\tT-2\nlast\tO\nyear\tO\nthey\tO\nbeat\tT-0\nUnited\tO\n's\tO\nbig\tO\nEnglish\tO\nrivals\tO\nLiverpool\tB-ORG\nin\tO\nthe\tO\nill-fated\tO\n1985\tO\nfinal\tO\nin\tO\nthe\tO\nHeysel\tO\nstadium\tO\nin\tO\nBrussels\tO\n.\tO\n\nBefore\tO\nconquering\tO\nAjax\tO\nlast\tO\nyear\tO\nthey\tO\nbeat\tO\nUnited\tO\n's\tO\nbig\tO\nEnglish\tO\nrivals\tO\nLiverpool\tT-0\nin\tO\nthe\tO\nill-fated\tO\n1985\tO\nfinal\tT-1\nin\tO\nthe\tO\nHeysel\tB-LOC\nstadium\tT-2\nin\tO\nBrussels\tO\n.\tO\n\nBefore\tO\nconquering\tO\nAjax\tO\nlast\tO\nyear\tO\nthey\tO\nbeat\tT-2\nUnited\tO\n's\tO\nbig\tO\nEnglish\tO\nrivals\tO\nLiverpool\tT-1\nin\tO\nthe\tO\nill-fated\tO\n1985\tO\nfinal\tO\nin\tO\nthe\tO\nHeysel\tO\nstadium\tO\nin\tT-0\nBrussels\tB-LOC\n.\tO\n\nNigeria\tB-LOC\npolice\tT-0\nkill\tT-1\nsix\tO\nrobbery\tO\nsuspects\tO\n.\tO\n\nNigerian\tB-MISC\npolice\tT-1\nshot\tO\ndead\tO\nsix\tO\nrobbery\tT-3\nsuspects\tO\nas\tO\nthey\tO\ntried\tO\nto\tO\nescape\tO\nfrom\tO\ncustody\tT-4\nin\tO\nthe\tO\nnorthern\tO\ncity\tO\nof\tO\nSokoto\tT-0\n,\tO\nthe\tO\nnational\tO\nnews\tO\nagency\tO\nreported\tT-2\non\tO\nFriday\tO\n.\tO\n\nNigerian\tO\npolice\tO\nshot\tT-0\ndead\tO\nsix\tO\nrobbery\tO\nsuspects\tO\nas\tO\nthey\tO\ntried\tT-1\nto\tO\nescape\tO\nfrom\tO\ncustody\tO\nin\tO\nthe\tO\nnorthern\tO\ncity\tO\nof\tO\nSokoto\tB-LOC\n,\tO\nthe\tO\nnational\tO\nnews\tO\nagency\tO\nreported\tT-2\non\tO\nFriday\tO\n.\tO\n\nThe\tO\nNews\tB-ORG\nAgency\tI-ORG\nof\tI-ORG\nNigeria\tI-ORG\n(\tO\nNAN\tT-0\n)\tO\nquoted\tT-1\npolice\tO\nspokesman\tO\nUmar\tO\nShelling\tO\nas\tO\nsaying\tO\nthe\tO\nsix\tO\nwere\tO\nkilled\tO\non\tO\nWednesday\tO\n.\tO\n\nThe\tO\nNews\tO\nAgency\tO\nof\tO\nNigeria\tO\n(\tO\nNAN\tB-ORG\n)\tO\nquoted\tO\npolice\tO\nspokesman\tT-0\nUmar\tO\nShelling\tO\nas\tO\nsaying\tO\nthe\tO\nsix\tO\nwere\tO\nkilled\tO\non\tO\nWednesday\tO\n.\tO\n\nThe\tO\nNews\tO\nAgency\tO\nof\tO\nNigeria\tO\n(\tO\nNAN\tO\n)\tO\nquoted\tO\npolice\tO\nspokesman\tO\nUmar\tB-PER\nShelling\tI-PER\nas\tO\nsaying\tT-0\nthe\tO\nsix\tO\nwere\tO\nkilled\tT-1\non\tO\nWednesday\tO\n.\tO\n\nRwandan\tB-MISC\ngroup\tO\nsays\tT-0\nexpulsion\tO\ncould\tO\nbe\tO\nimminent\tO\n.\tO\n\nRepatriation\tT-0\nof\tO\n1.1\tO\nmillion\tO\nRwandan\tB-MISC\nHutu\tI-MISC\nrefugees\tO\nannounced\tO\nby\tO\nZaire\tO\nand\tO\nRwanda\tO\non\tO\nThursday\tO\ncould\tO\nstart\tO\nwithin\tO\nthe\tO\nnext\tO\nfew\tO\ndays\tO\n,\tO\nan\tO\nexiled\tO\nRwandan\tO\nHutu\tO\nlobby\tO\ngroup\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nRepatriation\tT-0\nof\tO\n1.1\tO\nmillion\tO\nRwandan\tT-2\nHutu\tT-2\nrefugees\tO\nannounced\tO\nby\tO\nZaire\tB-LOC\nand\tO\nRwanda\tT-3\non\tO\nThursday\tO\ncould\tO\nstart\tO\nwithin\tO\nthe\tO\nnext\tO\nfew\tO\ndays\tO\n,\tO\nan\tO\nexiled\tO\nRwandan\tO\nHutu\tO\nlobby\tO\ngroup\tT-1\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nRepatriation\tT-2\nof\tO\n1.1\tO\nmillion\tO\nRwandan\tO\nHutu\tO\nrefugees\tO\nannounced\tO\nby\tO\nZaire\tT-3\nand\tO\nRwanda\tB-LOC\non\tO\nThursday\tO\ncould\tT-1\nstart\tT-1\nwithin\tO\nthe\tO\nnext\tO\nfew\tO\ndays\tO\n,\tO\nan\tO\nexiled\tO\nRwandan\tO\nHutu\tO\nlobby\tO\ngroup\tO\nsaid\tT-0\non\tO\nFriday\tO\n.\tO\n\nRepatriation\tO\nof\tO\n1.1\tO\nmillion\tT-1\nRwandan\tO\nHutu\tO\nrefugees\tO\nannounced\tO\nby\tO\nZaire\tO\nand\tO\nRwanda\tO\non\tO\nThursday\tO\ncould\tO\nstart\tO\nwithin\tO\nthe\tO\nnext\tO\nfew\tO\ndays\tO\n,\tO\nan\tO\nexiled\tT-0\nRwandan\tB-MISC\nHutu\tI-MISC\nlobby\tO\ngroup\tO\nsaid\tO\non\tO\nFriday\tO\n.\tO\n\nInnocent\tB-PER\nButare\tI-PER\n,\tO\nexecutive\tT-4\nsecretary\tT-4\nof\tO\nthe\tO\nRally\tO\nfor\tO\nthe\tO\nReturn\tO\nof\tO\nRefugees\tO\nand\tO\nDemocracy\tO\nin\tO\nRwanda\tT-0\n(\tO\nRDR\tO\n)\tO\nwhich\tO\nsays\tT-5\nit\tO\nhas\tO\nthe\tO\nsupport\tT-1\nof\tO\nRwanda\tO\n's\tO\nexiled\tO\nHutus\tO\n,\tO\nappealed\tO\nto\tO\nthe\tO\ninternational\tO\ncommunity\tO\nto\tO\ndeter\tO\nthe\tO\ntwo\tO\ncountries\tO\nfrom\tO\ngoing\tO\nahead\tO\nwith\tO\nwhat\tO\nit\tO\ntermed\tO\na\tO\n\"\tO\nforced\tT-2\nand\tO\ninhuman\tT-3\naction\tO\n\"\tO\n.\tO\n\nInnocent\tT-0\nButare\tT-0\n,\tO\nexecutive\tO\nsecretary\tO\nof\tO\nthe\tO\nRally\tB-ORG\nfor\tI-ORG\nthe\tI-ORG\nReturn\tI-ORG\nof\tI-ORG\nRefugees\tI-ORG\nand\tI-ORG\nDemocracy\tI-ORG\nin\tI-ORG\nRwanda\tI-ORG\n(\tO\nRDR\tT-1\n)\tO\nwhich\tO\nsays\tO\nit\tO\nhas\tO\nthe\tO\nsupport\tO\nof\tO\nRwanda\tO\n's\tO\nexiled\tO\nHutus\tO\n,\tO\nappealed\tO\nto\tO\nthe\tO\ninternational\tO\ncommunity\tO\nto\tO\ndeter\tO\nthe\tO\ntwo\tO\ncountries\tO\nfrom\tO\ngoing\tO\nahead\tO\nwith\tO\nwhat\tO\nit\tO\ntermed\tO\na\tO\n\"\tO\nforced\tT-2\nand\tO\ninhuman\tT-3\naction\tO\n\"\tO\n.\tO\n\nInnocent\tO\nButare\tO\n,\tO\nexecutive\tO\nsecretary\tO\nof\tO\nthe\tO\nRally\tT-1\nfor\tO\nthe\tO\nReturn\tT-2\nof\tT-2\nRefugees\tT-2\nand\tT-2\nDemocracy\tT-2\nin\tO\nRwanda\tT-0\n(\tO\nRDR\tB-ORG\n)\tO\nwhich\tO\nsays\tO\nit\tO\nhas\tO\nthe\tO\nsupport\tO\nof\tO\nRwanda\tO\n's\tO\nexiled\tO\nHutus\tO\n,\tO\nappealed\tO\nto\tO\nthe\tO\ninternational\tO\ncommunity\tO\nto\tO\ndeter\tO\nthe\tO\ntwo\tO\ncountries\tO\nfrom\tO\ngoing\tO\nahead\tO\nwith\tO\nwhat\tO\nit\tO\ntermed\tO\na\tO\n\"\tO\nforced\tO\nand\tO\ninhuman\tO\naction\tO\n\"\tO\n.\tO\n\nInnocent\tO\nButare\tT-2\n,\tO\nexecutive\tO\nsecretary\tO\nof\tO\nthe\tO\nRally\tO\nfor\tO\nthe\tO\nReturn\tO\nof\tO\nRefugees\tO\nand\tO\nDemocracy\tO\nin\tO\nRwanda\tO\n(\tO\nRDR\tO\n)\tO\nwhich\tO\nsays\tO\nit\tO\nhas\tO\nthe\tO\nsupport\tO\nof\tO\nRwanda\tB-LOC\n's\tT-0\nexiled\tO\nHutus\tO\n,\tO\nappealed\tT-1\nto\tO\nthe\tO\ninternational\tO\ncommunity\tO\nto\tO\ndeter\tO\nthe\tO\ntwo\tO\ncountries\tO\nfrom\tO\ngoing\tO\nahead\tO\nwith\tO\nwhat\tO\nit\tO\ntermed\tO\na\tO\n\"\tO\nforced\tO\nand\tO\ninhuman\tO\naction\tO\n\"\tO\n.\tO\n\nInnocent\tO\nButare\tO\n,\tO\nexecutive\tO\nsecretary\tO\nof\tO\nthe\tO\nRally\tO\nfor\tO\nthe\tO\nReturn\tT-1\nof\tO\nRefugees\tO\nand\tO\nDemocracy\tO\nin\tO\nRwanda\tO\n(\tO\nRDR\tO\n)\tO\nwhich\tO\nsays\tT-2\nit\tO\nhas\tO\nthe\tO\nsupport\tO\nof\tO\nRwanda\tO\n's\tO\nexiled\tO\nHutus\tB-MISC\n,\tO\nappealed\tT-3\nto\tO\nthe\tO\ninternational\tT-0\ncommunity\tT-0\nto\tO\ndeter\tO\nthe\tO\ntwo\tO\ncountries\tO\nfrom\tO\ngoing\tO\nahead\tO\nwith\tO\nwhat\tO\nit\tO\ntermed\tO\na\tO\n\"\tO\nforced\tO\nand\tO\ninhuman\tO\naction\tO\n\"\tO\n.\tO\n\nOrthodox\tT-2\nchurch\tT-2\nblown\tT-1\nup\tO\nin\tO\nsouthern\tT-0\nCroatia\tB-LOC\n.\tO\n\nSaboteurs\tT-1\nblew\tO\nup\tO\na\tO\nSerb\tB-MISC\northodox\tT-0\nchurch\tO\nin\tO\nsouthern\tO\nCroatia\tO\non\tO\nFriday\tO\nwith\tO\na\tO\nblast\tO\nwhich\tO\nalso\tO\ndamaged\tO\nfour\tO\nnearby\tO\nhomes\tO\n,\tO\nthe\tO\nstate\tO\nnews\tO\nagency\tO\nHina\tO\nreported\tO\n.\tO\n\nSaboteurs\tO\nblew\tO\nup\tO\na\tO\nSerb\tT-1\northodox\tO\nchurch\tO\nin\tO\nsouthern\tT-0\nCroatia\tB-LOC\non\tO\nFriday\tO\nwith\tO\na\tO\nblast\tO\nwhich\tO\nalso\tO\ndamaged\tO\nfour\tO\nnearby\tO\nhomes\tO\n,\tO\nthe\tO\nstate\tO\nnews\tO\nagency\tO\nHina\tT-2\nreported\tO\n.\tO\n\nSaboteurs\tO\nblew\tO\nup\tO\na\tO\nSerb\tT-1\northodox\tT-1\nchurch\tT-1\nin\tO\nsouthern\tT-0\nCroatia\tT-0\non\tO\nFriday\tO\nwith\tO\na\tO\nblast\tO\nwhich\tO\nalso\tO\ndamaged\tO\nfour\tO\nnearby\tO\nhomes\tT-2\n,\tO\nthe\tO\nstate\tO\nnews\tO\nagency\tO\nHina\tB-ORG\nreported\tO\n.\tO\n\nHINA\tB-ORG\nsaid\tT-2\nthe\tO\nchurch\tT-1\nin\tO\nthe\tO\nsmall\tO\nvillage\tO\nof\tO\nKarin\tT-0\nGornji\tT-0\n,\tO\n30\tO\nkm\tO\n(\tO\n19\tO\nmiles\tO\n)\tO\nnorth\tO\nof\tO\nZadar\tO\n,\tO\nwas\tO\ndestroyed\tO\nby\tO\nthe\tO\nmorning\tO\nattack\tO\n.\tO\n\nHINA\tO\nsaid\tO\nthe\tO\nchurch\tO\nin\tO\nthe\tO\nsmall\tO\nvillage\tT-0\nof\tO\nKarin\tB-LOC\nGornji\tI-LOC\n,\tO\n30\tO\nkm\tO\n(\tO\n19\tO\nmiles\tO\n)\tO\nnorth\tT-1\nof\tO\nZadar\tT-2\n,\tO\nwas\tO\ndestroyed\tO\nby\tO\nthe\tO\nmorning\tO\nattack\tO\n.\tO\n\nHINA\tT-0\nsaid\tT-1\nthe\tO\nchurch\tT-2\nin\tO\nthe\tO\nsmall\tO\nvillage\tO\nof\tO\nKarin\tO\nGornji\tO\n,\tO\n30\tO\nkm\tO\n(\tO\n19\tO\nmiles\tO\n)\tO\nnorth\tT-3\nof\tT-3\nZadar\tB-LOC\n,\tO\nwas\tT-4\ndestroyed\tT-4\nby\tT-4\nthe\tO\nmorning\tO\nattack\tO\n.\tO\n\nZadar\tB-LOC\npolice\tT-1\nsaid\tO\nin\tO\na\tO\nstatement\tO\nthey\tO\nhad\tO\nlaunched\tO\nan\tO\ninvestigation\tT-0\nand\tO\nwere\tO\ndoing\tO\ntheir\tO\nbest\tO\nto\tO\nfind\tO\nthe\tO\nperpetrators\tO\n.\tO\n\nHINA\tB-ORG\nsaid\tT-0\nit\tO\nwas\tO\nthe\tO\nfirst\tO\ntime\tO\nan\tO\northodox\tO\nchurch\tT-1\nhad\tO\nbeen\tO\nblown\tO\nup\tO\nin\tO\nthe\tO\nZadar\tT-2\nhinterland\tO\n,\tO\nwhere\tO\na\tO\nlarge\tO\nnumber\tO\nof\tO\nSerbs\tO\nlived\tO\nbefore\tO\nthe\tO\n1991\tO\nwar\tO\nover\tO\nCroatia\tO\n's\tO\nindependence\tO\nfrom\tO\nthe\tO\nYugoslav\tO\nfederation\tO\n.\tO\n\nHINA\tO\nsaid\tO\nit\tO\nwas\tO\nthe\tO\nfirst\tO\ntime\tO\nan\tO\northodox\tO\nchurch\tT-0\nhad\tO\nbeen\tO\nblown\tO\nup\tO\nin\tT-1\nthe\tT-1\nZadar\tB-LOC\nhinterland\tO\n,\tO\nwhere\tO\na\tO\nlarge\tO\nnumber\tO\nof\tO\nSerbs\tO\nlived\tO\nbefore\tO\nthe\tO\n1991\tO\nwar\tO\nover\tO\nCroatia\tO\n's\tO\nindependence\tO\nfrom\tO\nthe\tO\nYugoslav\tT-2\nfederation\tT-2\n.\tO\n\nHINA\tO\nsaid\tO\nit\tO\nwas\tO\nthe\tO\nfirst\tO\ntime\tO\nan\tO\northodox\tO\nchurch\tO\nhad\tO\nbeen\tO\nblown\tO\nup\tO\nin\tO\nthe\tO\nZadar\tT-2\nhinterland\tT-2\n,\tO\nwhere\tO\na\tO\nlarge\tO\nnumber\tT-0\nof\tT-0\nSerbs\tB-MISC\nlived\tT-1\nbefore\tO\nthe\tO\n1991\tO\nwar\tO\nover\tO\nCroatia\tO\n's\tO\nindependence\tO\nfrom\tO\nthe\tO\nYugoslav\tO\nfederation\tO\n.\tO\n\nHINA\tT-2\nsaid\tO\nit\tO\nwas\tO\nthe\tO\nfirst\tO\ntime\tO\nan\tO\northodox\tT-3\nchurch\tO\nhad\tO\nbeen\tO\nblown\tO\nup\tO\nin\tO\nthe\tO\nZadar\tT-4\nhinterland\tO\n,\tO\nwhere\tO\na\tO\nlarge\tO\nnumber\tO\nof\tO\nSerbs\tO\nlived\tO\nbefore\tO\nthe\tO\n1991\tO\nwar\tO\nover\tO\nCroatia\tB-LOC\n's\tO\nindependence\tT-1\nfrom\tO\nthe\tO\nYugoslav\tO\nfederation\tO\n.\tO\n\nHINA\tO\nsaid\tO\nit\tO\nwas\tO\nthe\tO\nfirst\tO\ntime\tO\nan\tO\northodox\tT-1\nchurch\tT-1\nhad\tO\nbeen\tO\nblown\tO\nup\tO\nin\tO\nthe\tO\nZadar\tO\nhinterland\tO\n,\tO\nwhere\tO\na\tO\nlarge\tO\nnumber\tO\nof\tO\nSerbs\tO\nlived\tO\nbefore\tO\nthe\tO\n1991\tO\nwar\tO\nover\tO\nCroatia\tO\n's\tO\nindependence\tO\nfrom\tO\nthe\tO\nYugoslav\tB-MISC\nfederation\tT-0\n.\tO\n\nThe\tO\narea\tO\nwas\tO\npart\tO\nof\tO\nthe\tO\nself-styled\tT-1\nstate\tT-1\nof\tT-1\nKrajina\tB-LOC\nproclaimed\tT-0\nby\tO\nminority\tO\nSerbs\tO\nin\tO\n1991\tO\nand\tO\nrecaptured\tO\nby\tO\nthe\tO\nCroatian\tO\narmy\tT-2\nlast\tO\nyear\tO\n.\tO\n\nThe\tT-2\narea\tT-2\nwas\tO\npart\tO\nof\tO\nthe\tO\nself-styled\tO\nstate\tO\nof\tO\nKrajina\tO\nproclaimed\tO\nby\tT-0\nminority\tT-0\nSerbs\tB-MISC\nin\tO\n1991\tO\nand\tO\nrecaptured\tO\nby\tO\nthe\tO\nCroatian\tT-1\narmy\tO\nlast\tO\nyear\tO\n.\tO\n\nThe\tO\narea\tO\nwas\tO\npart\tT-0\nof\tT-0\nthe\tT-0\nself-styled\tT-0\nstate\tT-0\nof\tT-0\nKrajina\tT-0\nproclaimed\tO\nby\tO\nminority\tO\nSerbs\tO\nin\tO\n1991\tO\nand\tO\nrecaptured\tO\nby\tO\nthe\tO\nCroatian\tB-MISC\narmy\tT-1\nlast\tO\nyear\tO\n.\tO\n\nUp\tO\nto\tO\n200,000\tO\nSerbs\tB-MISC\nfled\tT-1\nto\tO\nBosnia\tO\nand\tO\nYugoslavia\tO\n,\tO\nleaving\tO\nKrajina\tO\nvacant\tO\nand\tO\ndepopulated\tT-0\n.\tO\n\nUp\tO\nto\tO\n200,000\tO\nSerbs\tT-0\nfled\tO\nto\tO\nBosnia\tB-LOC\nand\tT-2\nYugoslavia\tT-2\n,\tO\nleaving\tO\nKrajina\tO\nvacant\tO\nand\tO\ndepopulated\tO\n.\tO\n\nUp\tO\nto\tO\n200,000\tT-0\nSerbs\tT-0\nfled\tT-1\nto\tT-1\nBosnia\tO\nand\tO\nYugoslavia\tB-LOC\n,\tO\nleaving\tT-2\nKrajina\tO\nvacant\tO\nand\tO\ndepopulated\tO\n.\tO\n\nUp\tO\nto\tO\n200,000\tO\nSerbs\tO\nfled\tT-2\nto\tO\nBosnia\tO\nand\tO\nYugoslavia\tO\n,\tO\nleaving\tT-1\nKrajina\tB-LOC\nvacant\tT-0\nand\tO\ndepopulated\tO\n.\tO\n\nHungary\tB-LOC\n's\tO\ngross\tO\nforeign\tT-0\ndebt\tT-1\nrises\tO\nin\tO\nJune\tO\n.\tO\n\nHungary\tB-LOC\n's\tO\ngross\tT-0\nforeign\tT-1\ndebt\tO\nrose\tO\nto\tO\n$\tO\n27.53\tO\nbillion\tO\nin\tO\nJune\tO\nfrom\tO\n$\tO\n27.25\tO\nbillion\tO\nin\tO\nMay\tO\n,\tO\nthe\tO\n\nNational\tB-ORG\nBank\tI-ORG\nof\tI-ORG\nHungary\tI-ORG\n(\tO\nNBH\tT-1\n)\tO\nsaid\tT-0\non\tO\nFriday\tO\n.\tO\n\nNational\tO\nBank\tO\nof\tO\nHungary\tO\n(\tO\nNBH\tB-ORG\n)\tO\nsaid\tT-0\non\tO\nFriday\tO\n.\tO\n\ngovernment\tO\nand\tO\nNBH\tB-ORG\n9,510.9\tO\n10,056.4\tT-0\n\nGermany\tB-LOC\n,\tO\nPoland\tT-0\ntighten\tO\ncooperation\tT-2\nagainst\tT-1\ncrime\tO\n.\tO\n\nGermany\tO\n,\tO\nPoland\tB-LOC\ntighten\tT-0\ncooperation\tO\nagainst\tO\ncrime\tO\n.\tO\n\nGermany\tB-LOC\nand\tO\nPoland\tO\nagreed\tT-0\non\tO\nFriday\tO\nto\tO\ntighten\tO\ncooperation\tO\nbetween\tO\ntheir\tO\nintelligence\tO\nservices\tO\nin\tO\nfighting\tO\ninternational\tT-1\norganised\tO\ncrime\tO\n,\tO\nPAP\tO\nnews\tO\nagency\tO\nreported\tO\n.\tO\n\nGermany\tT-0\nand\tO\nPoland\tB-LOC\nagreed\tO\non\tO\nFriday\tO\nto\tO\ntighten\tO\ncooperation\tO\nbetween\tO\ntheir\tO\nintelligence\tO\nservices\tO\nin\tO\nfighting\tO\ninternational\tO\norganised\tO\ncrime\tO\n,\tO\nPAP\tO\nnews\tO\nagency\tT-1\nreported\tO\n.\tO\n\nGermany\tO\nand\tO\nPoland\tO\nagreed\tT-2\non\tO\nFriday\tO\nto\tO\ntighten\tO\ncooperation\tO\nbetween\tO\ntheir\tO\nintelligence\tO\nservices\tO\nin\tO\nfighting\tT-0\ninternational\tO\norganised\tO\ncrime\tO\n,\tO\nPAP\tB-ORG\nnews\tO\nagency\tO\nreported\tT-1\n.\tO\n\nInterior\tB-ORG\nMinister\tT-0\nZbigniew\tT-2\nSiemiatkowski\tO\nand\tO\nBernd\tO\nSchmidbauer\tT-3\n,\tO\nGerman\tO\nintelligence\tO\nco-ordinator\tO\nin\tO\nHelmut\tO\nKohl\tO\n's\tO\nchancellery\tO\n,\tO\nsealed\tT-1\nthe\tO\ncloser\tO\nlinks\tO\nduring\tO\ntalks\tO\nin\tO\nWarsaw\tO\n.\tO\n\nInterior\tO\nMinister\tO\nZbigniew\tB-PER\nSiemiatkowski\tI-PER\nand\tO\nBernd\tT-1\nSchmidbauer\tT-1\n,\tO\nGerman\tO\nintelligence\tT-0\nco-ordinator\tO\nin\tO\nHelmut\tT-2\nKohl\tT-2\n's\tO\nchancellery\tO\n,\tO\nsealed\tO\nthe\tO\ncloser\tO\nlinks\tO\nduring\tO\ntalks\tO\nin\tO\nWarsaw\tO\n.\tO\n\nInterior\tO\nMinister\tT-0\nZbigniew\tO\nSiemiatkowski\tO\nand\tO\nBernd\tB-PER\nSchmidbauer\tI-PER\n,\tO\nGerman\tO\nintelligence\tO\nco-ordinator\tO\nin\tO\nHelmut\tO\nKohl\tO\n's\tO\nchancellery\tO\n,\tO\nsealed\tT-1\nthe\tO\ncloser\tO\nlinks\tO\nduring\tO\ntalks\tO\nin\tO\nWarsaw\tO\n.\tO\n\nInterior\tO\nMinister\tO\nZbigniew\tO\nSiemiatkowski\tO\nand\tO\nBernd\tO\nSchmidbauer\tO\n,\tO\nGerman\tB-MISC\nintelligence\tO\nco-ordinator\tO\nin\tO\nHelmut\tO\nKohl\tO\n's\tO\nchancellery\tO\n,\tO\nsealed\tO\nthe\tO\ncloser\tO\nlinks\tO\nduring\tO\ntalks\tT-0\nin\tO\nWarsaw\tO\n.\tO\n\nInterior\tO\nMinister\tO\nZbigniew\tO\nSiemiatkowski\tO\nand\tO\nBernd\tO\nSchmidbauer\tO\n,\tO\nGerman\tO\nintelligence\tO\nco-ordinator\tO\nin\tO\nHelmut\tB-PER\nKohl\tI-PER\n's\tO\nchancellery\tO\n,\tO\nsealed\tT-0\nthe\tO\ncloser\tT-1\nlinks\tT-1\nduring\tO\ntalks\tT-2\nin\tO\nWarsaw\tO\n.\tO\n\nInterior\tO\nMinister\tO\nZbigniew\tO\nSiemiatkowski\tO\nand\tO\nBernd\tO\nSchmidbauer\tO\n,\tO\nGerman\tO\nintelligence\tO\nco-ordinator\tO\nin\tO\nHelmut\tO\nKohl\tO\n's\tO\nchancellery\tO\n,\tO\nsealed\tT-1\nthe\tO\ncloser\tT-0\nlinks\tO\nduring\tO\ntalks\tO\nin\tO\nWarsaw\tB-LOC\n.\tO\n\nMinistry\tO\nspokesman\tO\nRyszard\tB-PER\nHincza\tI-PER\ntold\tT-0\nthe\tO\nPolish\tO\nagency\tO\nthe\tO\nservices\tO\nwould\tO\nwork\tO\ntogether\tO\nagainst\tO\nmafia-style\tO\ngroups\tO\n,\tO\ndrug\tO\nsmuggling\tO\nand\tO\nillegal\tO\ntrade\tO\nin\tO\narms\tO\nand\tO\nradioactive\tO\nmaterials\tO\n.\tO\n\nMinistry\tO\nspokesman\tO\nRyszard\tT-2\nHincza\tT-2\ntold\tT-0\nthe\tO\nPolish\tB-MISC\nagency\tT-1\nthe\tO\nservices\tO\nwould\tO\nwork\tO\ntogether\tO\nagainst\tO\nmafia-style\tT-3\ngroups\tO\n,\tO\ndrug\tT-4\nsmuggling\tT-4\nand\tO\nillegal\tT-5\ntrade\tO\nin\tO\narms\tO\nand\tO\nradioactive\tO\nmaterials\tO\n.\tT-3\n\nRussians\tB-MISC\n,\tO\nChechens\tO\nsay\tT-1\nobserving\tT-1\nGrozny\tT-0\nceasefire\tT-0\n.\tT-0\n\nRussians\tT-0\n,\tO\nChechens\tB-MISC\nsay\tO\nobserving\tT-1\nGrozny\tO\nceasefire\tT-2\n.\tO\n\nRussians\tO\n,\tO\nChechens\tT-1\nsay\tT-1\nobserving\tT-1\nGrozny\tB-LOC\nceasefire\tT-0\n.\tO\n\nRebel\tT-0\nfighters\tT-0\nand\tO\nRussian\tB-MISC\nsoldiers\tT-1\nsaid\tT-2\na\tO\nceasefire\tT-5\neffective\tO\nat\tO\nnoon\tO\n(\tO\n0800\tO\nGMT\tO\n)\tO\non\tO\nFriday\tO\nwas\tO\nbeing\tO\ngenerally\tO\nobserved\tT-3\n,\tO\nalthough\tO\nscattered\tO\ngunfire\tT-4\nechoed\tO\nthrough\tO\nthe\tO\nChechen\tO\ncapital\tO\nGrozny\tO\n.\tO\n\nRebel\tO\nfighters\tO\nand\tO\nRussian\tT-0\nsoldiers\tO\nsaid\tO\na\tO\nceasefire\tT-1\neffective\tT-1\nat\tO\nnoon\tO\n(\tO\n0800\tO\nGMT\tB-MISC\n)\tO\non\tO\nFriday\tO\nwas\tO\nbeing\tO\ngenerally\tO\nobserved\tO\n,\tO\nalthough\tO\nscattered\tO\ngunfire\tO\nechoed\tO\nthrough\tO\nthe\tO\nChechen\tO\ncapital\tO\nGrozny\tO\n.\tO\n\nRebel\tT-1\nfighters\tO\nand\tO\nRussian\tT-2\nsoldiers\tT-3\nsaid\tO\na\tO\nceasefire\tO\neffective\tO\nat\tO\nnoon\tO\n(\tO\n0800\tO\nGMT\tO\n)\tO\non\tO\nFriday\tO\nwas\tO\nbeing\tO\ngenerally\tO\nobserved\tO\n,\tO\nalthough\tO\nscattered\tO\ngunfire\tO\nechoed\tO\nthrough\tT-0\nthe\tT-0\nChechen\tB-MISC\ncapital\tT-4\nGrozny\tO\n.\tO\n\nRebel\tT-0\nfighters\tT-0\nand\tO\nRussian\tT-1\nsoldiers\tT-1\nsaid\tO\na\tO\nceasefire\tO\neffective\tO\nat\tO\nnoon\tO\n(\tO\n0800\tO\nGMT\tO\n)\tO\non\tO\nFriday\tO\nwas\tO\nbeing\tO\ngenerally\tO\nobserved\tO\n,\tO\nalthough\tO\nscattered\tO\ngunfire\tO\nechoed\tO\nthrough\tO\nthe\tO\nChechen\tO\ncapital\tO\nGrozny\tB-LOC\n.\tO\n\nThe\tO\nRussian\tB-MISC\narmy\tO\nsaid\tT-0\nearlier\tO\nit\tO\nwas\tO\npreparing\tO\nto\tO\nwithdraw\tO\nfrom\tO\nthe\tO\nrebel-dominated\tO\nsouthern\tO\nmountains\tO\nof\tO\nthe\tO\nregion\tO\nas\tO\npart\tO\nof\tO\nthe\tO\npeace\tO\ndeal\tO\nreached\tO\nwith\tO\nseparatists\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nThere\tO\nhas\tO\nbeen\tO\nsome\tO\nshooting\tT-0\nfrom\tO\ntheir\tO\nside\tO\nbut\tO\nit\tO\nhas\tO\nbeen\tO\nrelatively\tO\nquiet\tO\n,\tO\n\"\tO\nsaid\tT-1\nfighter\tO\nAslan\tB-PER\nShabazov\tI-PER\n,\tO\na\tO\nbearded\tO\nman\tO\nwearing\tO\na\tO\nwhite\tO\nt-shirt\tO\nand\tO\ncamoflage\tT-2\ntrousers\tT-2\n.\tO\n\nSoon\tO\nafter\tO\nhe\tO\nspoke\tO\nanother\tO\nburst\tO\nof\tO\ngunfire\tO\nrocked\tO\nthe\tO\ncourtyard\tO\nwhere\tO\nthe\tO\nrebels\tO\nhad\tO\nset\tO\nup\tO\ntheir\tO\nbase\tO\nand\tO\na\tO\ncaptured\tT-1\nRussian\tB-MISC\nT-72\tT-0\ntank\tT-0\nroared\tO\nout\tO\nto\tO\ninvestigate\tO\n.\tO\n\nSoon\tO\nafter\tO\nhe\tO\nspoke\tO\nanother\tO\nburst\tO\nof\tO\ngunfire\tO\nrocked\tO\nthe\tO\ncourtyard\tT-1\nwhere\tO\nthe\tO\nrebels\tO\nhad\tO\nset\tO\nup\tO\ntheir\tO\nbase\tO\nand\tO\na\tO\ncaptured\tT-0\nRussian\tT-2\nT-72\tB-MISC\ntank\tO\nroared\tO\nout\tO\nto\tO\ninvestigate\tO\n.\tO\n\nThe\tO\nseparatists\tO\n,\tO\nwho\tO\nswept\tO\ninto\tO\nGrozny\tB-LOC\non\tO\nAugust\tO\n6\tO\n,\tO\nstill\tO\ncontrol\tO\nlarge\tT-1\nareas\tT-1\nof\tO\nthe\tO\ncentre\tT-0\nof\tT-0\ntown\tT-0\n,\tO\nand\tO\nRussian\tO\nsoldiers\tO\nare\tO\nbased\tO\nat\tO\ncheckpoints\tO\non\tO\nthe\tO\napproach\tO\nroads\tO\n.\tO\n\nThe\tO\nseparatists\tO\n,\tO\nwho\tO\nswept\tT-1\ninto\tO\nGrozny\tO\non\tO\nAugust\tO\n6\tO\n,\tO\nstill\tO\ncontrol\tT-2\nlarge\tO\nareas\tO\nof\tO\nthe\tO\ncentre\tO\nof\tO\ntown\tO\n,\tO\nand\tO\nRussian\tB-MISC\nsoldiers\tO\nare\tO\nbased\tT-0\nat\tO\ncheckpoints\tT-3\non\tT-3\nthe\tT-3\napproach\tT-3\nroads\tT-3\n.\tO\n\n\"\tO\nThe\tO\nceasefire\tT-0\nis\tO\nbeing\tO\nobserved\tT-2\n,\tO\n\"\tO\nsaid\tT-3\nwoman\tT-1\nsoldier\tT-1\nSvetlana\tB-PER\nGoncharova\tI-PER\n,\tO\n35\tO\n,\tO\nshort\tO\ndark\tO\nhair\tO\npoking\tO\nout\tO\nfrom\tO\nunder\tO\na\tO\npeaked\tO\ncamouflage\tO\ncap\tO\n.\tO\n\nThe\tO\ntruce\tT-1\n,\tO\nthe\tO\nlatest\tO\nof\tO\nseveral\tO\n,\tO\nwas\tO\nagreed\tO\nin\tO\ntalks\tO\non\tO\nThursday\tO\nbetween\tT-0\nRussian\tB-MISC\npeacemaker\tT-2\nAlexander\tO\nLebed\tO\nand\tO\nrebel\tO\nchief-of-staff\tO\nAslan\tO\nMaskhadov\tO\n.\tO\n\nThe\tO\ntruce\tO\n,\tO\nthe\tO\nlatest\tO\nof\tO\nseveral\tO\n,\tO\nwas\tO\nagreed\tO\nin\tO\ntalks\tO\non\tO\nThursday\tO\nbetween\tO\nRussian\tO\npeacemaker\tT-1\nAlexander\tB-PER\nLebed\tI-PER\nand\tO\nrebel\tO\nchief-of-staff\tO\nAslan\tT-0\nMaskhadov\tT-0\n.\tO\n\nThe\tO\ntruce\tO\n,\tO\nthe\tO\nlatest\tO\nof\tO\nseveral\tO\n,\tO\nwas\tO\nagreed\tO\nin\tO\ntalks\tO\non\tO\nThursday\tO\nbetween\tO\nRussian\tO\npeacemaker\tO\nAlexander\tO\nLebed\tO\nand\tO\nrebel\tT-0\nchief-of-staff\tO\nAslan\tB-PER\nMaskhadov\tI-PER\n.\tO\n\nThe\tO\ntwo\tO\nalso\tO\nagreed\tT-1\nto\tO\nset\tT-0\nup\tT-0\njoint\tO\npatrols\tO\nin\tO\nGrozny\tB-LOC\n,\tO\nbut\tO\nGoncharova\tO\nsaid\tO\nshe\tO\nwas\tO\nsceptical\tO\nabout\tO\nwhether\tO\nthis\tO\ncould\tO\nwork\tO\n.\tO\n\nThe\tO\ntwo\tO\nalso\tO\nagreed\tT-1\nto\tO\nset\tO\nup\tO\njoint\tO\npatrols\tO\nin\tO\nGrozny\tO\n,\tO\nbut\tO\nGoncharova\tB-PER\nsaid\tT-0\nshe\tT-0\nwas\tT-0\nsceptical\tT-0\nabout\tO\nwhether\tO\nthis\tO\ncould\tO\nwork\tO\n.\tO\n\nWEATHER\tO\n-\tO\nConditions\tT-0\nat\tT-2\nCIS\tB-LOC\nairports\tT-1\n-\tO\nAugust\tO\n23\tO\n.\tO\n\nNo\tO\nclosures\tT-0\nof\tO\nairports\tT-3\nin\tO\nthe\tO\nCommonwealth\tB-LOC\nof\tI-LOC\nIndependent\tI-LOC\nStates\tI-LOC\nare\tO\nexpected\tT-2\non\tO\nAugust\tO\n24\tO\nand\tO\nAugust\tO\n25\tO\n,\tO\nthe\tO\nRussian\tT-4\nWeather\tO\nService\tO\nsaid\tT-1\non\tO\nFriday\tO\n.\tO\n\nNo\tO\nclosures\tO\nof\tO\nairports\tT-1\nin\tO\nthe\tO\nCommonwealth\tT-2\nof\tT-2\nIndependent\tT-2\nStates\tT-2\nare\tO\nexpected\tO\non\tO\nAugust\tO\n24\tO\nand\tO\nAugust\tO\n25\tO\n,\tO\nthe\tO\nRussian\tB-ORG\nWeather\tI-ORG\nService\tI-ORG\nsaid\tT-0\non\tO\nFriday\tO\n.\tO\n\n--\tO\nMoscow\tB-ORG\nNewsroom\tI-ORG\n+7095\tT-1\n941\tT-1\n8520\tT-1\n\nGranic\tB-PER\narrives\tT-0\nto\tO\nsign\tT-1\nCroatia-Yugoslavia\tT-2\ntreaty\tO\n.\tO\n\nGranic\tO\narrives\tT-1\nto\tT-1\nsign\tO\nCroatia-Yugoslavia\tB-LOC\ntreaty\tT-2\n.\tO\n\nYugoslavia\tB-LOC\nand\tO\nCroatia\tO\nwere\tO\npoised\tT-0\non\tO\nFriday\tO\nto\tO\nsign\tO\na\tO\nlandmark\tO\nnormalisation\tO\ntreaty\tT-1\nending\tO\nfive\tO\nyears\tO\nof\tO\ntensions\tO\nand\tO\npaving\tO\nway\tO\nfor\tO\nstabilisation\tO\nin\tO\nthe\tO\nBalkans\tO\n.\tO\n\nYugoslavia\tT-0\nand\tT-2\nCroatia\tB-LOC\nwere\tT-1\npoised\tT-1\non\tO\nFriday\tO\nto\tO\nsign\tO\na\tO\nlandmark\tO\nnormalisation\tO\ntreaty\tO\nending\tO\nfive\tO\nyears\tO\nof\tO\ntensions\tO\nand\tO\npaving\tO\nway\tO\nfor\tO\nstabilisation\tO\nin\tO\nthe\tO\nBalkans\tT-3\n.\tO\n\nYugoslavia\tO\nand\tO\nCroatia\tO\nwere\tO\npoised\tO\non\tO\nFriday\tO\nto\tO\nsign\tO\na\tO\nlandmark\tT-0\nnormalisation\tO\ntreaty\tT-3\nending\tO\nfive\tO\nyears\tO\nof\tO\ntensions\tO\nand\tO\npaving\tO\nway\tT-1\nfor\tO\nstabilisation\tO\nin\tT-2\nthe\tT-2\nBalkans\tB-LOC\n.\tO\n\nCroatian\tB-MISC\nForeign\tT-0\nMinister\tO\nMate\tO\nGranic\tO\nlanded\tT-1\nat\tO\nBelgrade\tO\nairport\tO\naboard\tO\na\tO\nCroatian\tO\ngovernment\tO\njet\tO\non\tO\nFriday\tO\nmorning\tO\nfor\tO\ntalks\tO\nwith\tO\nhis\tO\nYugoslav\tO\ncounterparts\tO\nand\tO\na\tO\nsigning\tO\nceremony\tO\nexpected\tO\naround\tO\nnoon\tO\n(\tO\n1000\tO\nGMT\tO\n)\tO\n.\tT-0\n\nCroatian\tT-1\nForeign\tT-1\nMinister\tT-2\nMate\tB-PER\nGranic\tI-PER\nlanded\tT-0\nat\tO\nBelgrade\tO\nairport\tO\naboard\tO\na\tO\nCroatian\tO\ngovernment\tO\njet\tO\non\tO\nFriday\tO\nmorning\tO\nfor\tO\ntalks\tO\nwith\tO\nhis\tO\nYugoslav\tO\ncounterparts\tO\nand\tO\na\tO\nsigning\tO\nceremony\tO\nexpected\tO\naround\tO\nnoon\tO\n(\tO\n1000\tO\nGMT\tO\n)\tO\n.\tO\n\nCroatian\tO\nForeign\tO\nMinister\tO\nMate\tT-2\nGranic\tT-2\nlanded\tT-0\nat\tT-0\nBelgrade\tB-LOC\nairport\tT-1\naboard\tO\na\tO\nCroatian\tO\ngovernment\tO\njet\tO\non\tO\nFriday\tO\nmorning\tO\nfor\tO\ntalks\tO\nwith\tO\nhis\tO\nYugoslav\tO\ncounterparts\tO\nand\tO\na\tO\nsigning\tO\nceremony\tO\nexpected\tO\naround\tO\nnoon\tO\n(\tO\n1000\tO\nGMT\tO\n)\tO\n.\tO\n\nCroatian\tT-0\nForeign\tO\nMinister\tO\nMate\tO\nGranic\tO\nlanded\tT-1\nat\tT-1\nBelgrade\tT-1\nairport\tT-1\naboard\tT-1\na\tT-1\nCroatian\tB-MISC\ngovernment\tT-2\njet\tT-2\non\tT-2\nFriday\tT-2\nmorning\tT-2\nfor\tO\ntalks\tO\nwith\tO\nhis\tO\nYugoslav\tO\ncounterparts\tO\nand\tO\na\tO\nsigning\tO\nceremony\tO\nexpected\tO\naround\tO\nnoon\tO\n(\tO\n1000\tO\nGMT\tO\n)\tO\n.\tO\n\nCroatian\tO\nForeign\tO\nMinister\tO\nMate\tO\nGranic\tO\nlanded\tO\nat\tO\nBelgrade\tO\nairport\tO\naboard\tT-1\na\tO\nCroatian\tO\ngovernment\tT-0\njet\tO\non\tO\nFriday\tO\nmorning\tO\nfor\tO\ntalks\tO\nwith\tO\nhis\tO\nYugoslav\tB-MISC\ncounterparts\tT-2\nand\tO\na\tO\nsigning\tO\nceremony\tO\nexpected\tO\naround\tO\nnoon\tO\n(\tO\n1000\tO\nGMT\tO\n)\tO\n.\tO\n\nCroatian\tO\nForeign\tO\nMinister\tO\nMate\tO\nGranic\tO\nlanded\tO\nat\tO\nBelgrade\tT-0\nairport\tO\naboard\tO\na\tO\nCroatian\tO\ngovernment\tO\njet\tO\non\tO\nFriday\tO\nmorning\tO\nfor\tO\ntalks\tO\nwith\tO\nhis\tO\nYugoslav\tO\ncounterparts\tT-2\nand\tO\na\tO\nsigning\tT-1\nceremony\tT-1\nexpected\tO\naround\tO\nnoon\tO\n(\tO\n1000\tO\nGMT\tB-MISC\n)\tO\n.\tO\n\nOn\tO\nThursday\tO\nthe\tO\nYugoslav\tB-MISC\ngovernment\tT-0\nendorsed\tO\nthe\tO\ntext\tO\nof\tO\nthe\tO\nagreement\tT-1\non\tO\nnormalising\tO\nrelations\tO\nbetween\tO\nthe\tO\ntwo\tO\ncountries\tO\n,\tO\nthe\tO\nYugoslav\tO\nnews\tO\nagency\tO\nTanjug\tT-2\nsaid\tO\n.\tO\n\nOn\tO\nThursday\tO\nthe\tO\nYugoslav\tO\ngovernment\tO\nendorsed\tO\nthe\tO\ntext\tO\nof\tO\nthe\tO\nagreement\tO\non\tO\nnormalising\tO\nrelations\tO\nbetween\tO\nthe\tO\ntwo\tO\ncountries\tO\n,\tO\nthe\tO\nYugoslav\tB-MISC\nnews\tO\nagency\tO\nTanjug\tO\nsaid\tT-0\n.\tO\n\nOn\tO\nThursday\tO\nthe\tO\nYugoslav\tT-2\ngovernment\tT-2\nendorsed\tT-3\nthe\tO\ntext\tO\nof\tO\nthe\tO\nagreement\tO\non\tO\nnormalising\tO\nrelations\tO\nbetween\tO\nthe\tO\ntwo\tO\ncountries\tO\n,\tO\nthe\tO\nYugoslav\tO\nnews\tO\nagency\tT-1\nTanjug\tB-ORG\nsaid\tT-0\n.\tO\n\n\"\tO\nThe\tO\ngovernment\tO\nassessed\tO\nthe\tO\nagreement\tT-1\nas\tO\na\tO\ncrucial\tO\nstep\tO\nto\tO\nresolving\tT-2\nthe\tO\nYugoslav\tB-MISC\ncrisis\tT-0\n,\tO\nensuring\tO\nthe\tO\nrestoration\tT-4\nof\tO\npeace\tT-3\nin\tO\nformer\tO\nYugoslavia\tO\n,\tO\n\"\tO\nit\tO\nsaid\tO\n.\tO\n\n\"\tO\nThe\tO\ngovernment\tT-0\nassessed\tO\nthe\tO\nagreement\tO\nas\tO\na\tO\ncrucial\tT-1\nstep\tO\nto\tO\nresolving\tO\nthe\tO\nYugoslav\tT-2\ncrisis\tO\n,\tO\nensuring\tO\nthe\tO\nrestoration\tO\nof\tO\npeace\tO\nin\tO\nformer\tO\nYugoslavia\tB-LOC\n,\tO\n\"\tO\nit\tO\nsaid\tO\n.\tO\n\nThe\tO\npact\tO\nends\tO\nfive\tO\nyears\tO\nof\tO\nhostility\tT-1\nafter\tO\nCroatia\tB-LOC\n's\tT-0\nsecession\tO\nfrom\tO\nfederal\tO\nYugoslavia\tO\n.\tO\n\nThe\tO\npact\tO\nends\tT-0\nfive\tO\nyears\tO\nof\tO\nhostility\tO\nafter\tO\nCroatia\tT-1\n's\tO\nsecession\tO\nfrom\tO\nfederal\tO\nYugoslavia\tB-LOC\n.\tO\n\nWestern\tB-MISC\npowers\tO\nregard\tO\ndiplomatic\tO\nnormalisation\tO\nbetween\tO\nCroatia\tT-0\nand\tO\nSerbia\tT-1\n,\tO\ntwin\tO\npillars\tO\nof\tO\nthe\tO\nold\tO\nmultinational\tO\nfederal\tO\nYugoslavia\tO\n,\tO\nas\tO\na\tO\ncrucial\tO\nstep\tO\ntowards\tO\na\tO\nlasting\tO\npeace\tO\nin\tO\nthe\tO\nBalkans\tO\n.\tO\n\nWestern\tO\npowers\tO\nregard\tO\ndiplomatic\tO\nnormalisation\tO\nbetween\tO\nCroatia\tB-LOC\nand\tT-3\nSerbia\tT-3\n,\tO\ntwin\tO\npillars\tO\nof\tO\nthe\tO\nold\tO\nmultinational\tO\nfederal\tO\nYugoslavia\tT-1\n,\tO\nas\tO\na\tO\ncrucial\tO\nstep\tO\ntowards\tO\na\tO\nlasting\tO\npeace\tO\nin\tO\nthe\tO\nBalkans\tT-2\n.\tO\n\nWestern\tO\npowers\tO\nregard\tO\ndiplomatic\tO\nnormalisation\tO\nbetween\tO\nCroatia\tT-1\nand\tO\nSerbia\tB-LOC\n,\tO\ntwin\tT-0\npillars\tT-0\nof\tO\nthe\tO\nold\tO\nmultinational\tO\nfederal\tO\nYugoslavia\tT-2\n,\tO\nas\tO\na\tO\ncrucial\tO\nstep\tO\ntowards\tO\na\tO\nlasting\tO\npeace\tO\nin\tO\nthe\tT-3\nBalkans\tT-3\n.\tO\n\nWestern\tO\npowers\tO\nregard\tO\ndiplomatic\tO\nnormalisation\tO\nbetween\tO\nCroatia\tT-0\nand\tO\nSerbia\tT-1\n,\tO\ntwin\tT-3\npillars\tO\nof\tO\nthe\tO\nold\tO\nmultinational\tT-2\nfederal\tO\nYugoslavia\tB-LOC\n,\tO\nas\tO\na\tO\ncrucial\tO\nstep\tO\ntowards\tO\na\tO\nlasting\tO\npeace\tO\nin\tO\nthe\tO\nBalkans\tO\n.\tO\n\nWestern\tT-1\npowers\tT-1\nregard\tO\ndiplomatic\tO\nnormalisation\tT-2\nbetween\tO\nCroatia\tO\nand\tO\nSerbia\tO\n,\tO\ntwin\tO\npillars\tO\nof\tO\nthe\tO\nold\tO\nmultinational\tO\nfederal\tO\nYugoslavia\tO\n,\tO\nas\tO\na\tO\ncrucial\tO\nstep\tO\ntowards\tO\na\tO\nlasting\tT-3\npeace\tT-0\nin\tO\nthe\tO\nBalkans\tB-LOC\n.\tO\n\nEcuador\tB-LOC\npresident\tT-1\nto\tO\nlunch\tT-0\nwith\tO\nethnic\tT-2\nIndians\tT-2\n.\tO\n\nEcuador\tO\npresident\tT-2\nto\tO\nlunch\tT-0\nwith\tO\nethnic\tT-1\nIndians\tB-MISC\n.\tO\n\nQUITO\tB-LOC\n,\tO\nEcuador\tT-0\n1996-08-23\tO\n\nQUITO\tT-0\n,\tO\nEcuador\tB-LOC\n1996-08-23\tO\n\nEcuador\tB-LOC\n's\tO\nPresident\tT-0\nAbdala\tO\nBucaram\tO\nhas\tO\nannounced\tT-1\nhe\tO\nwill\tO\nhold\tO\nregular\tO\nlunches\tO\nin\tO\nhis\tO\npresidential\tO\npalace\tT-2\nfor\tO\nmembers\tO\nof\tO\nthe\tO\ncountry\tO\n's\tO\ndifferent\tO\nethnic\tO\ngroups\tO\nas\tO\nof\tO\nnext\tO\nweek\tO\n.\tO\n\nEcuador\tT-0\n's\tT-0\nPresident\tT-2\nAbdala\tB-PER\nBucaram\tI-PER\nhas\tO\nannounced\tT-3\nhe\tO\nwill\tO\nhold\tO\nregular\tO\nlunches\tT-1\nin\tO\nhis\tO\npresidential\tO\npalace\tO\nfor\tO\nmembers\tO\nof\tO\nthe\tO\ncountry\tO\n's\tO\ndifferent\tO\nethnic\tO\ngroups\tO\nas\tO\nof\tO\nnext\tO\nweek\tO\n.\tO\n\n\"\tO\nIt\tO\nwas\tO\nabout\tO\ntime\tO\nfor\tO\nthe\tO\nIndians\tB-MISC\n,\tO\nthe\tO\nblacks\tT-0\nand\tO\nthe\tO\nmixed-bloods\tT-1\nto\tO\nbegin\tO\neating\tO\nin\tO\nthe\tO\npalace\tO\nwith\tO\ntheir\tO\npresident\tO\nbecause\tO\nthis\tO\nis\tO\nnot\tO\na\tO\npalace\tO\nexclusively\tO\nfor\tO\nthe\tO\npotentates\tO\nand\tO\nambassadors\tT-2\nand\tO\nprotocol\tO\n,\tO\n\"\tO\nBucaram\tO\nsaid\tO\nlate\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nIt\tO\nwas\tO\nabout\tO\ntime\tO\nfor\tO\nthe\tO\nIndians\tO\n,\tO\nthe\tO\nblacks\tO\nand\tO\nthe\tO\nmixed-bloods\tO\nto\tO\nbegin\tO\neating\tO\nin\tO\nthe\tO\npalace\tO\nwith\tO\ntheir\tO\npresident\tT-3\nbecause\tO\nthis\tO\nis\tO\nnot\tO\na\tO\npalace\tO\nexclusively\tO\nfor\tO\nthe\tO\npotentates\tT-1\nand\tO\nambassadors\tT-2\nand\tO\nprotocol\tO\n,\tO\n\"\tO\nBucaram\tB-PER\nsaid\tT-0\nlate\tO\non\tO\nThursday\tO\n.\tO\n\n\"\tO\nIn\tO\nthese\tO\nweekly\tO\nlunches\tO\nwe\tO\nare\tO\ngoing\tO\nto\tO\nget\tO\nto\tO\nknow\tO\nthe\tO\nproblems\tT-0\nof\tO\nthe\tO\nIndian\tB-MISC\n,\tO\nmixed-race\tO\n,\tO\nblack\tO\nand\tO\npeasant\tO\nsectors\tO\n,\tO\n\"\tO\nhe\tO\nsaid\tO\n.\tO\n\nHe\tO\nhas\tO\ninvited\tT-1\n35\tO\nIndian\tB-MISC\nleaders\tT-0\nto\tO\nlunch\tO\nnext\tO\nTuesday\tO\n.\tO\n\nBucaram\tB-PER\n,\tO\nwho\tO\nwas\tO\nelected\tT-0\non\tO\na\tO\npopulist\tT-1\nplatform\tO\nlast\tO\nmonth\tO\n,\tO\nalso\tO\nplans\tO\nto\tO\ncreate\tO\na\tO\nministry\tO\nfor\tO\nethnic\tO\ncultures\tO\n.\tO\n\nThe\tT-2\nAndean\tB-MISC\nnation\tO\n's\tO\npopulation\tT-1\nof\tO\n11.4\tO\nmillion\tO\nis\tO\n47\tO\npercent\tO\nindigenous\tT-0\n.\tO\n\nBrazil\tB-LOC\nto\tO\nuse\tT-1\nhovercrafts\tO\nfor\tO\nAmazon\tO\ntravel\tT-0\n.\tO\n\nBrazil\tT-0\nto\tO\nuse\tO\nhovercrafts\tT-1\nfor\tT-3\nAmazon\tB-LOC\ntravel\tT-2\n.\tO\n\nHovercrafts\tO\nwill\tO\nsoon\tO\nbe\tO\nplying\tO\nthe\tO\nwaters\tT-1\nof\tO\nthe\tO\nAmazon\tB-LOC\nin\tO\na\tO\nbid\tT-0\nto\tO\nreduce\tO\nthe\tO\ndifficulties\tO\nof\tO\ntransportation\tO\non\tO\nthe\tO\nvast\tO\nBrazilian\tT-2\nwaterway\tO\n,\tO\nthe\tO\ngovernment\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nHovercrafts\tT-0\nwill\tO\nsoon\tO\nbe\tO\nplying\tO\nthe\tO\nwaters\tT-1\nof\tT-1\nthe\tT-1\nAmazon\tO\nin\tO\na\tO\nbid\tO\nto\tO\nreduce\tO\nthe\tO\ndifficulties\tO\nof\tO\ntransportation\tT-3\non\tO\nthe\tO\nvast\tO\nBrazilian\tB-MISC\nwaterway\tT-2\n,\tO\nthe\tO\ngovernment\tO\nsaid\tO\non\tO\nThursday\tO\n.\tO\n\nTwo\tT-0\nRussian-built\tB-MISC\nhovercrafts\tT-1\n,\tO\ncapable\tO\nof\tO\ncarrying\tT-3\nup\tO\nto\tO\n50\tO\ntons\tO\neach\tO\n,\tO\nwill\tO\nbegin\tO\nferrying\tO\npassengers\tO\nand\tO\ncargo\tO\nup\tO\nand\tO\ndown\tO\nthe\tO\nhuge\tO\nriver\tO\nfrom\tO\nits\tO\nmouth\tO\nat\tO\nBelem\tO\nby\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nyear\tO\n,\tO\nBrazil\tO\n's\tO\nAmazon\tT-2\nAffairs\tT-2\nDepartment\tT-2\nsaid\tO\nin\tO\na\tO\nstatement\tO\n.\tO\n\nTwo\tO\nRussian-built\tO\nhovercrafts\tT-0\n,\tO\ncapable\tO\nof\tO\ncarrying\tO\nup\tO\nto\tO\n50\tO\ntons\tO\neach\tO\n,\tO\nwill\tO\nbegin\tO\nferrying\tO\npassengers\tO\nand\tO\ncargo\tO\nup\tO\nand\tO\ndown\tO\nthe\tO\nhuge\tO\nriver\tO\nfrom\tO\nits\tO\nmouth\tO\nat\tT-1\nBelem\tB-LOC\nby\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nyear\tO\n,\tO\nBrazil\tO\n's\tO\nAmazon\tO\nAffairs\tO\nDepartment\tO\nsaid\tO\nin\tO\na\tO\nstatement\tO\n.\tO\n\nTwo\tO\nRussian-built\tT-1\nhovercrafts\tO\n,\tO\ncapable\tO\nof\tO\ncarrying\tO\nup\tO\nto\tO\n50\tO\ntons\tO\neach\tO\n,\tO\nwill\tO\nbegin\tO\nferrying\tO\npassengers\tO\nand\tO\ncargo\tO\nup\tO\nand\tO\ndown\tO\nthe\tO\nhuge\tO\nriver\tO\nfrom\tO\nits\tO\nmouth\tO\nat\tO\nBelem\tO\nby\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nyear\tO\n,\tO\nBrazil\tB-LOC\n's\tO\nAmazon\tO\nAffairs\tO\nDepartment\tO\nsaid\tT-0\nin\tO\na\tO\nstatement\tO\n.\tT-1\n\nTwo\tO\nRussian-built\tO\nhovercrafts\tT-2\n,\tO\ncapable\tO\nof\tO\ncarrying\tT-0\nup\tO\nto\tO\n50\tO\ntons\tO\neach\tO\n,\tO\nwill\tO\nbegin\tO\nferrying\tO\npassengers\tO\nand\tO\ncargo\tO\nup\tO\nand\tO\ndown\tO\nthe\tO\nhuge\tO\nriver\tO\nfrom\tO\nits\tO\nmouth\tO\nat\tO\nBelem\tO\nby\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nyear\tO\n,\tO\nBrazil\tT-1\n's\tT-1\nAmazon\tB-ORG\nAffairs\tI-ORG\nDepartment\tI-ORG\nsaid\tO\nin\tO\na\tO\nstatement\tO\n.\tT-0\n\nThe\tO\nuse\tO\nof\tO\nriverways\tT-3\nin\tO\nthe\tT-1\nregion\tT-1\nhas\tO\nbeen\tO\nmade\tO\na\tO\npriority\tO\nunder\tO\na\tO\ngovernment\tO\nplan\tT-2\nfor\tT-2\nthe\tT-2\nAmazon\tB-LOC\nand\tO\nthe\tO\nhigh-speed\tO\nhovercraft\tO\nwill\tO\nhelp\tO\nreduce\tO\nthe\tO\ntime\tO\ninvolved\tO\nin\tO\ntravelling\tO\noften\tO\nmassive\tT-0\ndistances\tT-0\n,\tO\nit\tO\nsaid\tO\n.\tO\n\n"
  },
  {
    "path": "dataset/Laptop-reviews/test.txt",
    "content": "Boot\tB-aspectTerm\ntime\tI-aspectTerm\nis\tO\nsuper\tO\nfast\tO\n,\tO\naround\tO\nanywhere\tO\nfrom\tO\n35\tO\nseconds\tO\nto\tO\n1\tO\nminute\tO\n.\tO\n\ntech\tB-aspectTerm\nsupport\tI-aspectTerm\nwould\tO\nnot\tO\nfix\tO\nthe\tO\nproblem\tO\nunless\tO\nI\tO\nbought\tO\nyour\tO\nplan\tO\nfor\tO\n$\tO\n150\tO\nplus\tO\n.\tO\n\nbut\tO\nin\tO\nresume\tO\nthis\tO\ncomputer\tO\nrocks\tO\n!\tO\n\nSet\tB-aspectTerm\nup\tI-aspectTerm\nwas\tO\neasy\tO\n.\tO\n\nDid\tO\nnot\tO\nenjoy\tO\nthe\tO\nnew\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\nand\tO\ntouchscreen\tB-aspectTerm\nfunctions\tI-aspectTerm\n.\tO\n\nI\tO\nexpected\tO\nso\tO\nas\tO\nit\tO\n's\tO\nan\tO\nApple\tO\nproduct\tO\n,\tO\nbut\tO\nI\tO\nwas\tO\nglad\tO\nto\tO\nsee\tO\nmy\tO\nexpectations\tO\nexceeded\tO\n,\tO\nthis\tO\nis\tO\nTHE\tO\nlaptop\tO\nto\tO\nbuy\tO\nright\tO\nnow\tO\n.\tO\n\nOther\tO\nthan\tO\nnot\tO\nbeing\tO\na\tO\nfan\tO\nof\tO\nclick\tB-aspectTerm\npads\tI-aspectTerm\n(\tO\nindustry\tO\nstandard\tO\nthese\tO\ndays\tO\n)\tO\nand\tO\nthe\tO\nlousy\tO\ninternal\tB-aspectTerm\nspeakers\tI-aspectTerm\n,\tO\nit\tO\n's\tO\nhard\tO\nfor\tO\nme\tO\nto\tO\nfind\tO\nthings\tO\nabout\tO\nthis\tO\nnotebook\tO\nI\tO\ndo\tO\nn't\tO\nlike\tO\n,\tO\nespecially\tO\nconsidering\tO\nthe\tO\n$\tO\n350\tO\nprice\tB-aspectTerm\ntag\tI-aspectTerm\n.\tO\n\nexcellent\tO\nin\tO\nevery\tO\nway\tO\n.\tO\n\nNo\tO\ninstallation\tB-aspectTerm\ndisk\tI-aspectTerm\n(\tI-aspectTerm\nDVD\tI-aspectTerm\n)\tI-aspectTerm\nis\tO\nincluded\tO\n.\tO\n\nIt\tO\n's\tO\nfast\tO\n,\tO\nlight\tO\n,\tO\nand\tO\nsimple\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nWorks\tB-aspectTerm\nwell\tO\n,\tO\nand\tO\nI\tO\nam\tO\nextremely\tO\nhappy\tO\nto\tO\nbe\tO\nback\tO\nto\tO\nan\tO\napple\tB-aspectTerm\nOS\tI-aspectTerm\n.\tO\n\nThis\tO\nmac\tO\nhas\tO\nbeen\tO\na\tO\nproblem\tO\nsince\tO\nwe\tO\ngot\tO\nit\tO\n.\tO\n\nSure\tO\nit\tO\n's\tO\nnot\tO\nlight\tO\nand\tO\nslim\tO\nbut\tO\nthe\tO\nfeatures\tB-aspectTerm\nmake\tO\nup\tO\nfor\tO\nit\tO\n100\tO\n%\tO\n.\tO\n\nI\tO\nam\tO\npleased\tO\nwith\tO\nthe\tO\nfast\tO\nlog\tB-aspectTerm\non\tI-aspectTerm\n,\tO\nspeedy\tO\nWiFi\tB-aspectTerm\nconnection\tI-aspectTerm\nand\tO\nthe\tO\nlong\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n(\tO\n>\tO\n6\tO\nhrs\tO\n)\tO\n.\tO\n\nThe\tO\nApple\tO\nengineers\tO\nhave\tO\nnot\tO\nyet\tO\ndiscovered\tO\nthe\tO\ndelete\tB-aspectTerm\nkey\tI-aspectTerm\n.\tO\n\nMade\tO\ninterneting\tB-aspectTerm\n(\tO\npart\tO\nof\tO\nmy\tO\nbusiness\tO\n)\tO\nvery\tO\ndifficult\tO\nto\tO\nmaintain\tO\n.\tO\n\nLuckily\tO\n,\tO\nfor\tO\nall\tO\nof\tO\nus\tO\ncontemplating\tO\nthe\tO\ndecision\tO\n,\tO\nthe\tO\nMac\tO\nMini\tO\nis\tO\npriced\tB-aspectTerm\njust\tO\nright\tO\n.\tO\n\nSmall\tO\nand\tO\nstill\tO\nVERY\tO\npowerful\tO\n.\tO\n\nI\tO\nhad\tO\ngotten\tO\nthis\tO\nmodel\tO\nfor\tO\n$\tO\n1199.00\tO\non\tO\nmy\tO\nState\tO\n's\tO\ntax\tO\n-\tO\nfree\tO\nweekend\tO\nand\tO\nhad\tO\na\tO\n$\tO\n100\tO\noff\tO\ncoupon\tO\nfor\tO\na\tO\nMacBook\tO\nat\tO\nthe\tO\nlocal\tO\nBestBuy\tO\n!\tO\n\nSuper\tO\nlight\tO\n,\tO\nsuper\tO\nsexy\tO\nand\tO\neverything\tO\njust\tO\nworks\tB-aspectTerm\n.\tO\n\nOnly\tO\nproblem\tO\nthat\tO\nI\tO\nhad\tO\nwas\tO\nthat\tO\nthe\tO\ntrack\tB-aspectTerm\npad\tI-aspectTerm\nwas\tO\nnot\tO\nvery\tO\ngood\tO\nfor\tO\nme\tO\n,\tO\nI\tO\nonly\tO\nhad\tO\na\tO\nproblem\tO\nonce\tO\nor\tO\ntwice\tO\nwith\tO\nit\tO\n,\tO\nBut\tO\nprobably\tO\nmy\tO\ncomputer\tO\nwas\tO\na\tO\nbit\tO\ndefective\tO\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\nare\tO\nswitching\tO\nfrom\tO\na\tO\npc\tO\nI\tO\nhilghy\tO\nsugest\tO\nthis\tO\none\tO\n.\tO\n\nIt\tO\nis\tO\nsuper\tO\nfast\tO\nand\tO\nhas\tO\noutstanding\tO\ngraphics\tB-aspectTerm\n.\tO\n\nBut\tO\nthe\tO\nmountain\tB-aspectTerm\nlion\tI-aspectTerm\nis\tO\njust\tO\ntoo\tO\nslow\tO\n.\tO\n\nStrong\tO\nbuild\tB-aspectTerm\nthough\tO\nwhich\tO\nreally\tO\nadds\tO\nto\tO\nits\tO\ndurability\tB-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nexcellent-\tO\n6\tO\n-\tO\n7\tO\nhours\tO\nwithout\tO\ncharging\tO\n.\tO\n\nI\tO\nenjoy\tO\nhaving\tO\napple\tO\nproducts\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nmy\tO\ncomputer\tO\nfor\tO\n2\tO\nweeks\tO\nalready\tO\nand\tO\nit\tO\nworks\tB-aspectTerm\nperfectly\tO\n.\tO\n\nI\tO\nwill\tO\nnever\tO\ngo\tO\nback\tO\nto\tO\na\tO\nPC\tO\nagain\tO\n!\tO\n\nAnd\tO\nI\tO\nmay\tO\nbe\tO\nthe\tO\nonly\tO\none\tO\nbut\tO\nI\tO\nam\tO\nreally\tO\nliking\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\n.\tO\n\nThe\tO\nbaterry\tB-aspectTerm\nis\tO\nvery\tO\nlonger\tO\n.\tO\n\nAnd\tO\nit\tO\n's\tO\nso\tO\nquiet\tO\nthat\tO\nI\tO\ndo\tO\nn't\tO\nhear\tO\nit\tO\nat\tO\nall\tO\n.\tO\n\nIts\tO\nsize\tB-aspectTerm\nis\tO\nideal\tO\nand\tO\nthe\tO\nweight\tB-aspectTerm\nis\tO\nacceptable\tO\n.\tO\n\nI\tO\nknow\tO\nApples\tO\nare\tO\nmore\tO\nexpensive\tO\nthan\tO\nPCs\tO\n,\tO\nbut\tO\nhe\tO\nthinks\tO\nit\tO\nis\tO\nworth\tO\nevery\tO\npenny\tO\n.\tO\n\nTo\tO\nme\tO\nit\tO\n's\tO\na\tO\nworkhorse\tO\n...\tO\nand\tO\nquiet\tO\nas\tO\ncan\tO\nbe\tO\n...\tO\nyou\tO\neven\tO\nsave\tO\nbig\tO\nbucks\tO\nnot\tO\ndishing\tO\nout\tO\nany\tO\nextra\tO\nto\tO\nUncle\tO\nSam\tO\n...\tO\nDefinite\tO\nBuy\tO\n...\tO\n\nI\tO\ncan\tO\nsay\tO\nthat\tO\nI\tO\nam\tO\nfully\tO\nsatisfied\tO\nwith\tO\nthe\tO\nperformance\tB-aspectTerm\nthat\tO\nthe\tO\ncomputer\tO\nhas\tO\nsupplied\tO\n.\tO\n\nI\tO\n'm\tO\npretty\tO\nsure\tO\nwhen\tO\nI\tO\nbought\tO\nit\tO\n,\tO\nmy\tO\nbank\tO\naccount\tO\nwent\tO\n'\tO\nouch\tO\n!\tO\n\nThank\tO\nyou\tO\nso\tO\nmuch\tO\nfor\tO\nthe\tO\ngreat\tO\nitem\tO\n.\tO\n\nThis\tO\nlaptop\tO\nhas\tO\nonly\tO\n2\tO\nUSB\tB-aspectTerm\nports\tI-aspectTerm\n,\tO\nand\tO\nthey\tO\nare\tO\nboth\tO\non\tO\nthe\tO\nsame\tO\nside\tO\n.\tO\n\nIt\tO\n's\tO\nannoying\tO\nvery\tO\nmuch\tO\nand\tO\nI\tO\nwo\tO\nn't\tO\never\tO\nbuy\tO\nany\tO\nAcer\tO\nproducts\tO\n.\tO\n\nThis\tO\nis\tO\nwhy\tO\nI\tO\npurchased\tO\na\tO\nBRAND\tO\nNEW\tO\nLAPTOP\tO\nin\tO\nthe\tO\nfirst\tO\nplace\tO\nso\tO\nit\tO\nwould\tO\nn't\tO\nhave\tO\nANY\tO\nproblems\tO\n.\tO\n\nIt\tO\nhas\tO\nso\tO\nmuch\tO\nmore\tO\nspeed\tB-aspectTerm\nand\tO\nthe\tO\nscreen\tB-aspectTerm\nis\tO\nvery\tO\nsharp\tO\n.\tO\n\nAs\tO\nfor\tO\nthe\tO\nlaptop\tO\n,\tO\nthis\tO\nis\tO\nour\tO\n3rd\tO\nApple\tO\ncomputer\tO\nin\tO\nthe\tO\npast\tO\n2\tO\nyears\tO\n.\tO\n\nEverything\tO\nI\tO\nwanted\tO\nand\tO\neverything\tO\nI\tO\nneeded\tO\nand\tO\nthe\tO\nprice\tB-aspectTerm\nwas\tO\ngreat\tO\n!\tO\n\nIt\tO\n's\tO\nnot\tO\ninexpensive\tO\nbut\tO\nthe\tO\nHardware\tB-aspectTerm\nperformance\tI-aspectTerm\nis\tO\nimpressive\tO\nfor\tO\na\tO\ncomputer\tO\nthis\tO\nsmall\tO\n.\tO\n\nIt\tO\nis\tO\nbetter\tO\nthan\tO\nmy\tO\nold\tO\nacer\tO\nlaptop\tO\n.\tO\n\nThis\tO\nthing\tO\nis\tO\nawesome\tO\n,\tO\neverything\tO\nalways\tO\nworks\tB-aspectTerm\n,\tO\neverything\tO\nis\tO\nalways\tO\neasy\tO\nto\tO\nset\tB-aspectTerm\nup\tI-aspectTerm\n,\tO\neverything\tO\nis\tO\ncompatible\tO\n,\tO\nits\tO\nliterally\tO\neverything\tO\nI\tO\ncould\tO\nask\tO\nfor\tO\n.\tO\n\nI\tO\nwould\tO\nbuy\tO\nit\tO\nagain\tO\nin\tO\na\tO\nheartbeat\tO\n!\tO\n\nKeyboard\tB-aspectTerm\nresponds\tO\nwell\tO\nto\tO\npresses\tO\n.\tO\n\nIf\tO\nsomeone\tO\ncalled\tO\nme\tO\nan\tO\nApple\tO\nFanboy\tO\n...\tO\nit\tO\nwould\tO\nmake\tO\nsense\tO\n.\tO\n\nLastly\tO\n,\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\nis\tO\nannoying\tO\n.\tO\n\nA\tO\nscratch\tO\non\tO\na\tO\n$\tO\n1,500\tO\nMacBook\tO\nis\tO\nunforgivable\tO\n.\tO\n\nI\tO\njust\tO\nfell\tO\nin\tO\nlove\tO\nwith\tO\nthis\tO\nthing\tO\n.\tO\n\nEverything\tO\nis\tO\nso\tO\neasy\tO\nand\tO\nintuitive\tO\nto\tO\nsetup\tB-aspectTerm\nor\tO\nconfigure\tB-aspectTerm\n.\tO\n\nI\tO\nhave\tO\nno\tO\nproblems\tO\nyet\tO\non\tO\nmy\tO\nmac\tO\nso\tO\nfar\tO\n,\tO\nand\tO\nhope\tO\nit\tO\nstays\tO\nlike\tO\nthat\tO\n.\tO\n\nThis\tO\nlaptop\tO\nis\tO\na\tO\ngreat\tO\nbuy\tO\n.\tO\n\nBiggest\tO\ncomplaint\tO\nis\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\n.\tO\n\nOnly\tO\n2\tO\nusb\tB-aspectTerm\nports\tI-aspectTerm\n...\tO\nseems\tO\nkind\tO\nof\tO\n...\tO\nlimited\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nto\tO\nearly\tO\nto\tO\nsee\tO\nif\tO\nthis\tO\nactually\tO\nfixes\tO\nthe\tO\nproblem\tO\nor\tO\nnot\tO\nthough\tO\n.\tO\n\nThis\tO\ndevice\tO\nhas\tO\nmet\tO\nmy\tO\nexpectations\tO\nand\tO\nI\tO\n'm\tO\nsure\tO\nit\tO\nwill\tO\nmeet\tO\nyours\tO\n.\tO\n\nIt\tO\nhas\tO\nall\tO\nthe\tO\nexpected\tO\nfeatures\tB-aspectTerm\nand\tO\nmore\tO\n+\tO\nplus\tO\na\tO\nwide\tO\nscreen\tB-aspectTerm\nand\tO\nmore\tO\nthan\tO\nroomy\tO\nkeyboard\tB-aspectTerm\n.\tO\n\nOut\tO\nof\tO\nall\tO\nthe\tO\nlaptops\tO\nI\tO\nhave\tO\nowned\tO\n,\tO\nthis\tO\nis\tO\nby\tO\nfar\tO\nthe\tO\nbest\tO\n!\tO\n\nAmazing\tO\nPerformance\tB-aspectTerm\nfor\tO\nanything\tO\nI\tO\nthrow\tO\nat\tO\nit\tO\n.\tO\n\nI\tO\ncan\tO\nnever\tO\ngo\tO\nback\tO\nto\tO\na\tO\nPC\tO\nnow\tO\n,\tO\nthis\tO\nmachine\tO\nnever\tO\nfreezes\tO\nor\tO\nhas\tO\nany\tO\nproblems\tO\n.\tO\n\nOut\tO\nof\tO\nthe\tO\nbox\tO\nI\tO\nnoticed\tO\nhow\tO\nsmall\tO\nit\tO\nwas\tO\nand\tO\nwas\tO\nexactly\tO\nwhat\tO\nI\tO\nwas\tO\nlooking\tO\nfor\tO\n.\tO\n\nThe\tO\nreceiver\tO\nwas\tO\nfull\tO\nof\tO\nsuperlatives\tO\nfor\tO\nthe\tO\nquality\tB-aspectTerm\nand\tO\nperformance\tB-aspectTerm\n.\tO\n\nI\tO\nwas\tO\nextremely\tO\nhappy\tO\nwith\tO\nthe\tO\nOS\tB-aspectTerm\nitself\tO\n.\tO\n\nI\tO\nwas\tO\nlooking\tO\nfor\tO\nsomething\tO\nin\tO\nbetween\tO\na\tO\nregular\tO\nlaptop\tO\nand\tO\na\tO\ntablet\tO\nand\tO\nthis\tO\nis\tO\nit\tO\n.\tO\n\nThe\tO\nnew\tO\nMBP\tO\noffers\tO\ngreat\tO\nportability\tB-aspectTerm\nand\tO\ngives\tO\nus\tO\nconfidence\tO\nthat\tO\nwe\tO\nare\tO\nnot\tO\ngoing\tO\nto\tO\nneed\tO\nto\tO\npurchase\tO\na\tO\nnew\tO\nlaptop\tO\nin\tO\n18\tO\nmonths\tO\n.\tO\n\nGreat\tO\npurchase\tO\nand\tO\nI\tO\ndefinitely\tO\ndid\tO\nn't\tO\nmiss\tO\nout\tO\non\tO\nthe\tO\nBlack\tO\nFriday\tO\ndeals\tO\n.\tO\n\nThe\tO\ncriticism\tO\nhas\tO\nwaned\tO\n,\tO\nand\tO\nnow\tO\nI\tO\n'd\tO\nbe\tO\nthe\tO\nfirst\tO\nto\tO\nrecommend\tO\nan\tO\nAir\tO\nfor\tO\ntruly\tO\nportable\tB-aspectTerm\ncomputing\tI-aspectTerm\n.\tO\n\nI\tO\nwould\tO\nhave\tO\ngiven\tO\nit\tO\n5\tO\nstarts\tO\nwas\tO\nit\tO\nnot\tO\nfor\tO\nthe\tO\nfact\tO\nthat\tO\nit\tO\nhad\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\n\nMS\tB-aspectTerm\nOffice\tI-aspectTerm\n2011\tI-aspectTerm\nfor\tI-aspectTerm\nMac\tI-aspectTerm\nis\tO\nwonderful\tO\n,\tO\nwell\tO\nworth\tO\nit\tO\n.\tO\n\nAfter\tO\nusing\tO\nit\tO\nfor\tO\nover\tO\na\tO\nmonth\tO\n,\tO\nan\tO\nissue\tO\nstarted\tO\nto\tO\nsurface\tO\n.\tO\n\nBut\tO\nthe\tO\nperformance\tB-aspectTerm\nof\tO\nMac\tO\nMini\tO\nis\tO\na\tO\nhuge\tO\ndisappointment\tO\n.\tO\n\nThere\tO\nhas\tO\nbeen\tO\nno\tO\nproblem\tO\nwith\tO\nanything\tO\n.\tO\n\nI\tO\nbelieve\tO\nwith\tO\nApple\tO\n-\tO\nyou\tO\nget\tO\nwhat\tO\nyou\tO\npay\tO\nfor\tO\n.\tO\n\nThey\tO\ndo\tO\nn't\tO\njust\tO\nlook\tB-aspectTerm\ngood\tO\n;\tO\nthey\tO\ndeliver\tO\nexcellent\tO\nperformance\tB-aspectTerm\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nit\tO\nover\tO\na\tO\nyear\tO\nnow\tO\nwith\tO\nout\tO\na\tO\nGlitch\tO\nof\tO\nany\tO\nkind\tO\n..\tO\nI\tO\nlove\tO\nthe\tO\nlit\tB-aspectTerm\nup\tI-aspectTerm\nkeys\tI-aspectTerm\nand\tO\nscreen\tB-aspectTerm\ndisplay\tI-aspectTerm\n...\tO\nthis\tO\nthing\tO\nis\tO\nFast\tO\nand\tO\nclear\tO\nas\tO\ncan\tO\nbe\tO\n.\tO\n\nThe\tO\nproduct\tO\nis\tO\nprefect\tO\nfor\tO\neveryone\tO\n.\tO\n\nThe\tO\nMountain\tB-aspectTerm\nLion\tI-aspectTerm\nOS\tI-aspectTerm\nis\tO\nnot\tO\nhard\tO\nto\tO\nfigure\tO\nout\tO\nif\tO\nyou\tO\nare\tO\nfamiliar\tO\nwith\tO\nMicrosoft\tB-aspectTerm\nWindows\tI-aspectTerm\n.\tO\n\nHowever\tO\n,\tO\nI\tO\ncan\tO\nrefute\tO\nthat\tO\nOSX\tB-aspectTerm\nis\tO\n\"\tO\nFAST\tO\n\"\tO\n.\tO\n\nI\tO\nwaited\tO\nto\tO\nreview\tO\nto\tO\nmake\tO\nsure\tO\nit\tO\nis\tO\nwhat\tO\nit\tO\nis\tO\n.\tO\n\nEnjoy\tO\nusing\tO\nMicrosoft\tB-aspectTerm\nOffice\tI-aspectTerm\n!\tO\n\nI\tO\nwould\tO\nsuggest\tO\nthis\tO\nproduct\tO\nto\tO\nanyone\tO\n.\tO\n\nWith\tO\nno\tO\nproblems\tO\n,\tO\nI\tO\n'm\tO\nhappy\tO\nwith\tO\nthis\tO\npurchase\tO\nbecause\tO\nI\tO\nsaved\tO\nmoney\tO\ncompared\tO\nto\tO\nbuying\tO\nit\tO\nanywhere\tO\nelse\tO\n.\tO\n\nIncredible\tO\ngraphics\tB-aspectTerm\nand\tO\nbrilliant\tO\ncolors\tB-aspectTerm\n.\tO\n\nI\tO\nneeded\tO\nsomething\tO\naffordable\tO\nfrom\tO\nApple\tO\nand\tO\nwas\tO\ntired\tO\nof\tO\ndealing\tO\nwith\tO\nPC\tO\nlaptop\tO\nafter\tO\nPC\tO\nlaptop\tO\n.\tO\n\nJust\tO\nbit\tO\nthe\tO\nbullet\tO\nand\tO\nbought\tO\nthe\tO\nMac\tO\nhoping\tO\nit\tO\nwill\tO\nlast\tO\na\tO\nlot\tO\nlonger\tO\n…\tO\n.\tO\n\nBuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\napps\tI-aspectTerm\nare\tO\npurely\tO\namazing\tO\n.\tO\n\nCons\tO\n:\tO\nScreen\tB-aspectTerm\nresolution\tI-aspectTerm\n.\tO\n\nFrom\tO\nthe\tO\nspeed\tB-aspectTerm\nto\tO\nthe\tO\nmulti\tB-aspectTerm\ntouch\tI-aspectTerm\ngestures\tI-aspectTerm\nthis\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nbeats\tO\nWindows\tB-aspectTerm\neasily\tO\n.\tO\n\nI\tO\nreally\tO\nlike\tO\nthe\tO\nsize\tB-aspectTerm\nand\tO\nI\tO\n'm\tO\na\tO\nfan\tO\nof\tO\nthe\tO\nACERS\tO\n.\tO\n\nThis\tO\nis\tO\nby\tO\nfar\tO\nthee\tO\nbest\tO\n,\tO\nmost\tO\nreliable\tO\ncomputer\tO\nI\tO\ncould\tO\nfind\tO\n.\tO\n\nI\tO\nopted\tO\nfor\tO\nthe\tO\nSquareTrade\tB-aspectTerm\n3-Year\tI-aspectTerm\nComputer\tI-aspectTerm\nAccidental\tI-aspectTerm\nProtection\tI-aspectTerm\nWarranty\tI-aspectTerm\n(\tO\n$\tO\n1500\tO\n-\tO\n2000\tO\n)\tO\nwhich\tO\nalso\tO\nsupport\tO\n\"\tO\naccidents\tO\n\"\tO\nlike\tO\ndrops\tO\nand\tO\nspills\tO\nthat\tO\nare\tO\nNOT\tO\ncovered\tO\nby\tO\nAppleCare\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nlight\tO\nand\tO\neasy\tO\nto\tO\ntransport\tB-aspectTerm\n.\tO\n\nOnce\tO\nyou\tO\nget\tO\npast\tO\nlearning\tO\nhow\tO\nto\tO\nuse\tO\nthe\tO\npoorly\tO\ndesigned\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\nSet\tI-aspectTerm\n-\tI-aspectTerm\nUp\tI-aspectTerm\nyou\tO\nmay\tO\nfeel\tO\nfrustrated\tO\n.\tO\n\nVery\tO\npowerful\tO\nespecially\tO\nfor\tO\nthe\tO\nmoney\tO\n.\tO\n\nWhen\tO\nmy\tO\nDell\tO\nlaptop\tO\ngave\tO\nup\tO\nonly\tO\nafter\tO\n2\tO\n1/2\tO\nyears\tO\n,\tO\nI\tO\ndecided\tO\nto\tO\nbuy\tO\nMacBook\tO\nPro\tO\n.\tO\n\nIt\tO\n's\tO\nbeen\tO\ntime\tO\nfor\tO\na\tO\nnew\tO\nlaptop\tO\n,\tO\nand\tO\nthe\tO\nonly\tO\ndebate\tO\nwas\tO\nwhich\tO\nsize\tB-aspectTerm\nof\tO\nthe\tO\nMac\tO\nlaptops\tO\n,\tO\nand\tO\nwhether\tO\nto\tO\nspring\tO\nfor\tO\nthe\tO\nretina\tB-aspectTerm\ndisplay\tI-aspectTerm\n.\tO\n\nThis\tO\nwas\tO\na\tO\nsignificantly\tO\nmore\tO\naffordable\tO\nthan\tO\ngetting\tO\na\tO\nnew\tO\nMacBook\tO\nPro\tO\nfrom\tO\nApple\tO\n.\tO\n\nI\tO\nhave\tO\nalways\tO\nwanted\tO\na\tO\nMacBook\tO\nPro\tO\n.....\tO\nalways\tO\n!\tO\n\nThe\tO\nreason\tO\nwhy\tO\nI\tO\nchoose\tO\napple\tO\nMacBook\tO\nbecause\tO\nof\tO\ntheir\tO\ndesign\tB-aspectTerm\nand\tO\nthe\tO\naluminum\tB-aspectTerm\ncasing\tI-aspectTerm\n.\tO\n\nThe\tO\naluminum\tB-aspectTerm\nbody\tI-aspectTerm\nsure\tO\nmakes\tO\nit\tO\nstand\tO\nout\tO\n.\tO\n\nOverall\tO\nit\tO\n's\tO\nan\tO\namazing\tO\nproduct\tO\n,\tO\n5\tO\nstars\tO\n!\tO\n\nIt\tO\nis\tO\nvery\tO\neasy\tO\nto\tO\nintegrate\tB-aspectTerm\nbluetooth\tI-aspectTerm\ndevices\tI-aspectTerm\n,\tO\nand\tO\nUSB\tB-aspectTerm\ndevices\tI-aspectTerm\nare\tO\nrecognized\tO\nalmost\tO\ninstantly\tO\n.\tO\n\nHe\tO\n's\tO\nthrilled\tO\nwith\tO\nhis\tO\nnew\tO\nlaptop\tO\n.\tO\n\nAmazing\tO\nproduct\tO\nas\tO\nyou\tO\nwould\tO\nexpect\tO\nfrom\tO\nApple\tO\n.\tO\n\nNothing\tO\nwrong\tO\nwith\tO\nthis\tO\ncomputer\tO\nat\tO\nall\tO\n!\tO\n\nAnd\tO\nthe\tO\nfact\tO\nthat\tO\nApple\tO\nis\tO\ndriving\tO\nthe\tO\n13\tO\n\"\tO\nRMBP\tO\nwith\tO\nthe\tO\nIntel4000\tB-aspectTerm\ngraphic\tI-aspectTerm\nchip\tI-aspectTerm\nseems\tO\nunderpowered\tO\n(\tO\nto\tO\nme\tO\n.\tO\n\nI\tO\nhave\tO\nto\tO\nwonder\tO\nwhy\tO\nAmazon\tO\nis\tO\neven\tO\nselling\tO\nthis\tO\ndinosaur\tO\n.\tO\n\nApple\tO\nremoved\tO\nthe\tO\nDVD\tB-aspectTerm\ndrive\tI-aspectTerm\nFirewire\tI-aspectTerm\nport\tI-aspectTerm\n(\tO\nwill\tO\nwork\tO\nwith\tO\nadapter\tB-aspectTerm\n)\tO\nand\tO\nput\tO\nthe\tO\nSDXC\tB-aspectTerm\nslot\tI-aspectTerm\nin\tO\na\tO\nsilly\tO\nposition\tO\non\tO\nthe\tO\nback\tO\n.\tO\n\nNo\tO\nhassle\tO\nand\tO\nno\tO\ncomplaints\tO\n.\tO\n\nLOVE\tO\nIT\tO\nI\tO\n've\tO\nalways\tO\nbeen\tO\nan\tO\napple\tO\nfan\tO\nboy\tO\n,\tO\nbut\tO\nnever\tO\nhad\tO\nthe\tO\nmoney\tO\nto\tO\nbuy\tO\na\tO\nmac\tO\n,\tO\nonly\tO\nipads\tO\nand\tO\niphones\tO\n,\tO\nand\tO\nthis\tO\nis\tO\nmy\tO\nfirst\tO\nmac\tO\n,\tO\nblew\tO\nme\tO\naway\tO\ncompletely\tO\n.\tO\n\nThe\tO\ndurability\tB-aspectTerm\nof\tO\nthe\tO\nlaptop\tO\nwill\tO\nmake\tO\nit\tO\nworth\tO\nthe\tO\nmoney\tO\n.\tO\n\nWell\tO\ndesigned\tB-aspectTerm\nand\tO\nfast\tO\n.\tO\n\nAnd\tO\nnow\tO\nI\tO\nam\tO\na\tO\nproud\tO\nMacBook\tO\nowner\tO\nalso\tO\n!\tO\n\nBut\tO\nI\tO\nwas\tO\ncompletely\tO\nwrong\tO\n,\tO\nthis\tO\ncomputer\tO\nis\tO\nUNBELIEVABLE\tO\namazing\tO\nand\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nExactly\tO\nas\tO\nposted\tO\nplus\tO\na\tO\ngreat\tO\nvalue\tB-aspectTerm\n.\tO\n\nThe\tO\nspecs\tB-aspectTerm\nare\tO\npretty\tO\ngood\tO\ntoo\tO\n.\tO\n\nI\tO\nam\tO\nhaving\tO\na\tO\nfriend\tO\nlook\tO\nat\tO\nit\tO\n,\tO\nbut\tO\nwill\tO\nprobably\tO\nreturn\tO\nit\tO\n.\tO\n\nThere\tO\nwere\tO\nno\tO\nscratches\tO\nor\tO\ndents\tO\nor\tO\nany\tO\nmarks\tO\nat\tO\nall\tO\n.\tO\n\nI\tO\n've\tO\nonly\tO\nhad\tO\nit\tO\none\tO\nday\tO\n,\tO\nbut\tO\nI\tO\nreally\tO\ndo\tO\nlove\tO\nit\tO\nand\tO\nI\tO\n'm\tO\nhappy\tO\nit\tO\nwas\tO\neconomical\tO\nand\tO\nI\tO\n'm\tO\nfinally\tO\nable\tO\nto\tO\nown\tO\na\tO\nMac\tO\n!\tO\n\nSince\tO\nI\tO\nhave\tO\nalways\tO\nused\tO\nApple\tO\nproducts\tO\n,\tO\nthe\tO\nchoice\tO\nof\tO\nMacbook\tO\nPro\tO\nwas\tO\nobvious\tO\n.\tO\n\nApple\tO\nis\tO\nunmatched\tO\nin\tO\nproduct\tB-aspectTerm\nquality\tI-aspectTerm\n,\tO\naesthetics\tB-aspectTerm\n,\tO\ncraftmanship\tB-aspectTerm\n,\tO\nand\tO\ncustomer\tB-aspectTerm\nservice\tI-aspectTerm\n.\tO\n\nThis\tO\nis\tO\nmy\tO\nfirst\tO\napple\tO\nlaptop\tO\n.\tO\n\nIt\tO\nmakes\tO\na\tO\ngreat\tO\ngift\tO\n.\tO\n\nIt\tO\nis\tO\na\tO\ngreat\tO\nsize\tB-aspectTerm\nand\tO\namazing\tO\nwindows\tB-aspectTerm\n8\tI-aspectTerm\nincluded\tO\n!\tO\n\nI\tO\nwould\tO\nrecommend\tO\nto\tO\nany\tO\none\tO\nlloking\tO\nfor\tO\na\tO\nfirst\tO\nclass\tO\ncomputer\tO\n!\tO\n\nI\tO\ndo\tO\nnot\tO\nlike\tO\ntoo\tO\nmuch\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\n.\tO\n\nStartup\tB-aspectTerm\ntimes\tI-aspectTerm\nare\tO\nincredibly\tO\nlong\tO\n:\tO\nover\tO\ntwo\tO\nminutes\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nMacbook\tO\nPro\tO\nfrom\tO\nBest\tO\nBuy\tO\nunder\tO\na\tO\nyear\tO\nago\tO\nto\tO\nreplace\tO\nmy\tO\nold\tO\nMacbook\tO\nAir\tO\n.\tO\n\nThe\tO\nmacbook\tO\npro\tO\nis\tO\nreally\tO\nresponsive\tO\n.\tO\n\nAlso\tO\nstunning\tO\ncolors\tB-aspectTerm\nand\tO\nspeedy\tO\n\nit\tO\nis\tO\nreally\tO\nexpensive\tO\nthough\tO\n.\tO\n\ngreat\tO\nprice\tB-aspectTerm\nfree\tO\nshipping\tB-aspectTerm\nwhat\tO\nelse\tO\ncan\tO\ni\tO\nask\tO\nfor\tO\n!\tO\n!\tO\n\nThis\tO\nmouse\tB-aspectTerm\nis\tO\nterrific\tO\n.\tO\n\nI\tO\nwill\tO\nalso\tO\nsay\tO\nit\tO\nis\tO\nmuch\tO\nbetter\tO\nthan\tO\nI\tO\nexpected\tO\n!\tO\n\nThis\tO\ncomputer\tO\ndoes\tO\neverything\tO\ni\tO\nneed\tO\nit\tO\nto\tO\ndo\tO\nfor\tO\nschool\tO\nand\tO\nmore\tO\n.\tO\n\nIt\tO\nis\tO\nreally\tO\nthick\tO\naround\tO\nthe\tO\nbattery\tB-aspectTerm\n.\tO\n\nAnd\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nworks\tO\nlike\tO\na\tO\ncharm\tO\n.\tO\n\nAnd\tO\nI\tO\ncan\tO\nattach\tO\nmy\tO\nprojector\tO\nto\tO\nit\tO\n.\tO\n\n:)\tO\nGreat\tO\nproduct\tO\n,\tO\ngreat\tO\nprice\tB-aspectTerm\n,\tO\ngreat\tO\ndelivery\tB-aspectTerm\n,\tO\nand\tO\ngreat\tO\nservice\tB-aspectTerm\n.\tO\n\n:]\tO\nIt\tO\narrived\tO\nso\tO\nfast\tO\nand\tO\ncustomer\tB-aspectTerm\nservice\tI-aspectTerm\nwas\tO\ngreat\tO\n.\tO\n\ntried\tO\nwindows\tB-aspectTerm\n8\tI-aspectTerm\nand\tO\nhated\tO\nit\tO\n!\tO\n!\tO\n!\tO\n\nThe\tO\nprice\tB-aspectTerm\nis\tO\nhigher\tO\nthan\tO\nmost\tO\nlab\tO\ntop\tO\nout\tO\nthere\tO\n;\tO\nhowever\tO\n,\tO\nhe\tO\n/\tO\nshe\tO\nwill\tO\nget\tO\nwhat\tO\nthey\tO\npaid\tO\nfor\tO\n,\tO\nwhich\tO\nis\tO\na\tO\ngreat\tO\ncomputer\tO\n.\tO\n\nSo\tO\n,\tO\nI\tO\nthought\tO\nwhy\tO\nnot\tO\ngive\tO\nMac\tO\nBook\tO\npro\tO\na\tO\ntry\tO\n.\tO\n\nSet\tB-aspectTerm\nup\tI-aspectTerm\nwas\tO\na\tO\nbreeze\tO\n.\tO\n\nBut\tO\nI\tO\ndo\tO\nNOT\tO\nlike\tO\nWin8\tB-aspectTerm\n.\tO\n\nI\tO\nhave\tO\nowned\tO\nat\tO\nleast\tO\n4\tO\nto\tO\n5\tO\nlaptops\tO\nand\tO\ncomputers\tO\n-\tO\nbut\tO\nthis\tO\nis\tO\nby\tO\nfar\tO\nthe\tO\nmost\tO\nsuperior\tO\nmachine\tO\nI\tO\nhave\tO\never\tO\nowned\tO\n.\tO\n\nI\tO\nam\tO\nstill\tO\nin\tO\nthe\tO\nprocess\tO\nof\tO\nlearning\tO\nabout\tO\nits\tO\nfeatures\tB-aspectTerm\n.\tO\n\nBTW\tO\n,\tO\nI\tO\nchecked\tO\nonline\tO\nregarding\tO\nthe\tO\nold\tO\nlaptop\tO\nthat\tO\n'\tO\ndied\tO\n'\tO\nand\tO\nfound\tO\nthat\tO\nI\tO\nwas\tO\nnot\tO\nalone\tO\n,\tO\nfar\tO\nfrom\tO\nit\tO\n.\tO\n\nI\tO\nhad\tO\nthe\tO\nsame\tO\nreasons\tO\nas\tO\nmost\tO\nPC\tO\nusers\tO\n:\tO\nthe\tO\nprice\tB-aspectTerm\n,\tO\nthe\tO\noverbearing\tO\nrestrictions\tO\nof\tO\nOSX\tB-aspectTerm\nand\tO\nlack\tO\nof\tO\nsupport\tB-aspectTerm\nfor\tI-aspectTerm\ngames\tI-aspectTerm\n.\tO\n\nI\tO\nwanted\tO\nit\tO\nfor\tO\nit\tO\n's\tO\nmobility\tB-aspectTerm\nand\tO\nman\tO\n,\tO\nthis\tO\nlittle\tO\nbad\tO\nboy\tO\nis\tO\nvery\tO\nnice\tO\n.\tO\n\nSeems\tO\nto\tO\nme\tO\nthat\tO\n's\tO\nthe\tO\nbest\tO\nway\tO\nto\tO\nget\tO\nApple\tO\n's\tO\nattention\tO\n.\tO\n\nVery\tO\nnice\tO\nso\tO\nfar\tO\n.\tO\n\nYou\tO\nwo\tO\nn't\tO\nbe\tO\ndisappointed\tO\n.\tO\n\nThe\tO\ninvestment\tO\nof\tO\na\tO\nnew\tO\nMacBook\tO\nPro\tO\ncame\tO\nat\tO\na\tO\nprice\tB-aspectTerm\n,\tO\nbut\tO\ntotally\tO\nworth\tO\nit\tO\nfor\tO\na\tO\ngood\tO\npiece\tO\nof\tO\nmind\tO\n.\tO\n\nI\tO\nfound\tO\nthe\tO\nmini\tO\nto\tO\nbe\tO\n:\tO\nExceptionally\tO\neasy\tO\nto\tO\nset\tB-aspectTerm\nup\tI-aspectTerm\n\nHaving\tO\nUSB3\tB-aspectTerm\nis\tO\nwhy\tO\nI\tO\nbought\tO\nthis\tO\nMini\tO\n.\tO\n\nBe\tO\nsure\tO\nto\tO\nhave\tO\ngood\tO\nair\tO\nflow\tO\nwhere\tO\never\tO\nyou\tO\nput\tO\nit\tO\n.\tO\n\nThe\tO\nsound\tB-aspectTerm\nis\tO\nnice\tO\nand\tO\nloud\tO\n;\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nany\tO\nproblems\tO\nwith\tO\nhearing\tO\nanything\tO\n.\tO\n\nIt\tO\nis\tO\nvery\tO\nslim\tO\n,\tO\nthe\tO\ntrack\tB-aspectTerm\npad\tI-aspectTerm\nis\tO\nvery\tO\nmuch\tO\nimpressed\tO\nwith\tO\nme\tO\n.\tO\n\nThis\tO\nwas\tO\nthe\tO\nsame\tO\nproblem\tO\nwith\tO\nmy\tO\nMacBook\tO\n(\tO\ncirca\tO\n2007\tO\n)\tO\nthat\tO\nI\tO\njust\tO\nretired\tO\n.\tO\n\nGreat\tO\nthings\tO\ncome\tO\nin\tO\nsmall\tO\n\"\tO\npackages\tO\n.\tO\n\nHUGE\tO\nApple\tO\nMAC\tO\nFan\tO\n!\tO\n\nLooked\tO\nat\tO\nHP\tO\n,\tO\nASUS\tO\n,\tO\nAcer\tO\n,\tO\nSony\tO\nand\tO\na\tO\nbunch\tO\nof\tO\nother\tO\nones\tO\nbut\tO\ncould\tO\nnot\tO\nfind\tO\nI\tO\nreally\tO\nliked\tO\n.\tO\n\nThe\tO\nsettings\tB-aspectTerm\nare\tO\nnot\tO\nuser\tO\n-\tO\nfriendly\tO\neither\tO\n.\tO\n\nHonestly\tO\n,\tO\nI\tO\nam\tO\nsurprised\tO\nno\tO\none\tO\nelse\tO\nhas\tO\nmentioned\tO\nreturning\tO\ntheirs\tO\n.\tO\n\nMost\tO\nof\tO\nthem\tO\nwere\tO\neither\tO\ntoo\tO\nbig\tO\n,\tO\ntoo\tO\nnoisy\tO\nand\tO\ntoo\tO\nslow\tO\nafter\tO\n2\tO\nyears\tO\n.\tO\n\nThe\tO\nmachine\tO\nis\tO\nused\tO\n,\tO\nbut\tO\nis\tO\nlike\tO\nnew\tO\n,\tO\ni\tO\n'm\tO\nvery\tO\nimpress\tO\n.\tO\n\nThank\tO\ngoodness\tO\nfor\tO\nOpenOffice\tB-aspectTerm\n!\tO\n\nAwesome\tO\nform\tB-aspectTerm\nfactor\tI-aspectTerm\n,\tO\ngreat\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n,\tO\nwonderful\tO\nUX\tB-aspectTerm\n.\tO\n\nNeedless\tO\nto\tO\nsay\tO\n,\tO\nthe\tO\nleap\tO\nfrom\tO\nthat\tO\nto\tO\nthis\tO\nhas\tO\nbeen\tO\namazing\tO\nand\tO\n(\tO\naside\tO\nfrom\tO\nthe\tO\nfinancial\tO\nreasons\tO\n)\tO\nI\tO\nam\tO\nastounded\tO\nthat\tO\nI\tO\nhad\tO\nn't\tO\nmade\tO\nthe\tO\nswitch\tO\nsooner\tO\n.\tO\n\nIts\tO\nperfect\tO\n,\tO\nnot\tO\nmuch\tO\nheavy\tO\n.\tO\n\ni\tO\nlove\tO\nthe\tO\nkeyboard\tB-aspectTerm\nand\tO\nthe\tO\nscreen\tB-aspectTerm\n.\tO\n\nI\tO\nfind\tO\nit\tO\nnot\tO\nto\tO\nbe\tO\nvery\tO\nuser\tO\nfriendly\tO\n.\tO\n\nIt\tO\nhas\tO\nsurpassed\tO\nall\tO\nexpectations\tO\nand\tO\nfulfilled\tO\nall\tO\nmy\tO\nneeds\tO\n.\tO\n\nHowever\tO\n,\tO\nthere\tO\nare\tO\nMAJOR\tO\nissues\tO\nwith\tO\nthe\tO\ntouchpad\tB-aspectTerm\nwhich\tO\nrender\tO\nthe\tO\ndevice\tO\nnearly\tO\nuseless\tO\n.\tO\n\nWhat\tO\nangers\tO\nme\tO\nmore\tO\nthan\tO\nanything\tO\nelse\tO\nis\tO\nthat\tO\nI\tO\nspent\tO\nall\tO\nthose\tO\nyears\tO\nhating\tO\nMACs\tO\nwhen\tO\nI\tO\ncould\tO\nhave\tO\nbeen\tO\ngetting\tO\na\tO\nlot\tO\nmore\tO\nproduction\tO\nwith\tO\na\tO\nwhole\tO\nlot\tO\nless\tO\ngrief\tO\n!\tO\n\nI\tO\n've\tO\nalready\tO\nupgraded\tO\no\tO\nMavericks\tB-aspectTerm\nand\tO\nI\tO\nam\tO\nimpressed\tO\nwith\tO\neverything\tO\nabout\tO\nthis\tO\ncomputer\tO\n.\tO\n\nSo\tO\nthis\tO\nis\tO\nvery\tO\ngood\tO\ncommputer\tO\nand\tO\ni\tO\nhighly\tO\nsuggest\tO\nit\tO\n.\tO\n\nthe\tO\nmbp\tO\ni\tO\nrecieved\tO\nwas\tO\neverything\tO\nit\tO\nshould\tO\nhave\tO\nbeen\tO\n.\tO\n\nI\tO\nwas\tO\ngoing\tO\nto\tO\nbuy\tO\ntoday\tO\nand\tO\nnoticed\tO\nit\tO\nwent\tO\nback\tO\nup\tO\nto\tO\n$\tO\n344.99\tO\n?\tO\n\nNot\tO\nas\tO\nfast\tO\nas\tO\nI\tO\nwould\tO\nhave\tO\nexpect\tO\nfor\tO\nan\tO\ni5\tB-aspectTerm\n.\tO\n\nSO\tO\nof\tO\ncourse\tO\nthis\tO\none\tO\ncame\tO\nthrough\tO\nwith\tO\nthe\tO\nawesomeness\tO\n!\tO\n\nYou\tO\nwill\tO\nnot\tO\nregret\tO\nbuying\tO\nthis\tO\ncomputer\tO\n!\tO\n\nNothing\tO\nbad\tO\nto\tO\nsay\tO\nabout\tO\nit\tO\n.\tO\n\nIt\tO\ns\tO\nheavy\tO\nfor\tO\nMac\tO\nbook\tO\nbut\tO\nis\tO\ngood\tO\n.\tO\n\nthanks\tO\nfor\tO\ngreat\tO\nservice\tB-aspectTerm\nand\tO\nshipping\tB-aspectTerm\n!\tO\n\nDeal\tO\nof\tO\nthe\tO\nyear\tO\n.\tO\n\nMy\tO\nsisters\tO\nsame\tO\nlaptop\tO\nbroke\tO\nabout\tO\nthe\tO\nmonth\tO\nlater\tO\nfor\tO\nthe\tO\nsame\tO\nreason\tO\n.\tO\n\nMinis\tO\nmake\tO\nsense\tO\nfor\tO\na\tO\nlot\tO\nof\tO\npeople\tO\n.\tO\n\nThe\tO\nperformance\tB-aspectTerm\nseems\tO\nquite\tO\ngood\tO\n,\tO\nand\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\napplications\tI-aspectTerm\nlike\tO\niPhoto\tB-aspectTerm\nwork\tO\ngreat\tO\nwith\tO\nmy\tO\nphone\tO\nand\tO\ncamera\tO\n.\tO\n\nThis\tO\nMac\tO\nMini\tO\nmakes\tO\nthe\tO\nMacbook\tO\nPro\tO\nseem\tO\nslow\tO\n.\tO\n\nI\tO\ndid\tO\nswap\tO\nout\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nfor\tO\na\tO\nSamsung\tB-aspectTerm\n830\tI-aspectTerm\nSSD\tI-aspectTerm\nwhich\tO\nI\tO\nhighly\tO\nrecommend\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nMacBook\tO\nPro\tO\nto\tO\nreplace\tO\nmy\tO\nsix\tO\n-\tO\nyear\tO\n-\tO\nold\tO\nPC\tO\n(\tO\na\tO\nSony\tO\nVaio\tO\n)\tO\n,\tO\nbut\tO\nit\tO\nwas\tO\nbasically\tO\nno\tO\nbetter\tO\nthan\tO\nmy\tO\nold\tO\nPC\tO\n,\tO\nso\tO\nI\tO\nreturned\tO\nit\tO\n.\tO\n\nI\tO\nwanted\tO\na\tO\nsimple\tO\n,\tO\nreliable\tO\nlaptop\tO\n.\tO\n\nCheaper\tO\nthan\tO\nbuying\tO\nit\tO\n@\tO\napple\tO\ntoo\tO\n!\tO\n\nI\tO\nhave\tO\njust\tO\nhad\tO\nto\tO\nlearn\tO\nto\tO\nbe\tO\na\tO\nlittle\tO\nharder\tO\ntyper\tO\nthan\tO\non\tO\nmy\tO\nlast\tO\ncomputer\tO\n.\tO\n\nExtremely\tO\ndisappointed\tO\nwith\tO\nthe\tO\nway\tO\nit\tO\nis\tO\n.\tO\n\nNever\tO\nbeen\tO\nhappier\tO\nusing\tO\ncomputer\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\na\tO\ntotal\tO\nof\tO\n5\tO\ndifferent\tO\nlaptop\tO\nfrom\tO\nmany\tO\ndifferent\tO\nmanufactures\tO\n.\tO\n\nDoes\tO\neverything\tO\nI\tO\nwanted\tO\nthis\tO\nlaptop\tO\nto\tO\ndo\tO\n.\tO\n\nBesides\tO\n,\tO\nthe\tO\napple\tO\nstocks\tO\nhave\tO\nbeen\tO\nfalling\tO\ndue\tO\nto\tO\nlack\tO\nof\tO\nsales\tO\n.\tO\n\nTurns\tO\nout\tO\nthis\tO\nis\tO\na\tO\ncommon\tO\nproblem\tO\n.\tO\n\nStarts\tB-aspectTerm\nup\tI-aspectTerm\nin\tO\na\tO\nhurry\tO\nand\tO\neverything\tO\nis\tO\nready\tO\nto\tO\ngo\tO\n.\tO\n\nIt\tO\nis\tO\nalso\tO\nfast\tO\nas\tO\ncan\tO\nbe\tO\n...\tO\nyou\tO\nget\tO\nwhat\tO\nyou\tO\npay\tO\nfor\tO\n...\tO\nwell\tO\nworth\tO\nthe\tO\ninvestment\tO\n\nBut\tO\nI\tO\n'm\tO\nstill\tO\nlearning\tO\nso\tO\nca\tO\nn't\tO\nrate\tO\nit\tO\nyet\tO\nfor\tO\neverything\tO\n.\tO\n\nOverall\tO\nvery\tO\nimpressed\tO\n,\tO\nThank\tO\nyou\tO\nApple\tO\nand\tO\nAmazon\tO\n!\tO\n\nYes\tO\n,\tO\nthat\tO\n's\tO\na\tO\ngood\tO\nthing\tO\n,\tO\nbut\tO\nit\tO\n's\tO\nmade\tO\nfrom\tO\naluminum\tB-aspectTerm\nthat\tO\nscratches\tO\neasily\tO\n.\tO\n\nVery\tO\nfast\tO\nfor\tO\nmy\tO\nneeds\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nMac\tO\nin\tO\norder\tO\nto\tO\nreplace\tO\nmy\tO\nold\tO\nDell\tO\nlaptop\tO\n.\tO\n\nQuick\tO\nand\tO\nhas\tO\nbuilt\tB-aspectTerm\nin\tI-aspectTerm\nvirus\tI-aspectTerm\ncontrol\tI-aspectTerm\n.\tO\n\nTook\tO\na\tO\nlong\tO\ntime\tO\ntrying\tO\nto\tO\ndecide\tO\nbetween\tO\none\tO\nwith\tO\nretina\tB-aspectTerm\ndisplay\tI-aspectTerm\nand\tO\none\tO\nwithout\tO\n.\tO\n\nI\tO\nsaw\tO\nthe\tO\nMini\tO\nMac\tO\nat\tO\nBest\tO\nBuy\tO\nand\tO\ndecided\tO\nto\tO\nget\tO\nthis\tO\nas\tO\nmy\tO\nreplacement\tO\n.\tO\n\nI\tO\nfinally\tO\ndecided\tO\non\tO\nthis\tO\none\tO\nand\tO\ncould\tO\nn't\tO\nbe\tO\nany\tO\nhappier\tO\n.\tO\n\nI\tO\nwas\tO\nalso\tO\ninformed\tO\nthat\tO\nthe\tO\ncomponents\tB-aspectTerm\nof\tO\nthe\tO\nMac\tO\nBook\tO\nwere\tO\ndirty\tO\n.\tO\n\nSo\tO\nglad\tO\nI\tO\ndid\tO\nnot\tO\nwaste\tO\nmoney\tO\non\tO\na\tO\nless\tO\nthan\tO\npar\tO\nproduct\tO\n.\tO\n\nHave\tO\nn't\tO\nregretted\tO\nit\tO\none\tO\nbit\tO\n.\tO\n\nThe\tO\none\tO\nthing\tO\nthat\tO\nApple\tO\ndoes\tO\nright\tO\nis\tO\ncomputers\tO\n.\tO\n\nthe\tO\nhardware\tB-aspectTerm\nproblems\tO\nhave\tO\nbeen\tO\nso\tO\nbad\tO\n,\tO\ni\tO\nca\tO\nn't\tO\nwait\tO\ntill\tO\nit\tO\ncompletely\tO\ndies\tO\nin\tO\n3\tO\nyears\tO\n,\tO\nTOPS\tO\n!\tO\n\nIt\tO\n's\tO\nso\tO\nnice\tO\nthat\tO\nthe\tO\nbattery\tB-aspectTerm\nlast\tO\nso\tO\nlong\tO\nand\tO\nthat\tO\nthis\tO\nmachine\tO\nhas\tO\nthe\tO\nsnow\tB-aspectTerm\nlion\tI-aspectTerm\n!\tO\n\nI\tO\nthink\tO\nthat\tO\nthey\tO\nare\tO\nthe\tO\nbest\tO\nout\tO\non\tO\nthe\tO\nmarket\tO\n.\tO\n\nHOWEVER\tO\nI\tO\nchose\tO\ntwo\tO\nday\tO\nshipping\tB-aspectTerm\nand\tO\nit\tO\ntook\tO\nover\tO\na\tO\nweek\tO\nto\tO\narrive\tO\n.\tO\n\nThat\tO\n's\tO\nquite\tO\na\tO\nbump\tO\nup\tO\nfrom\tO\nthe\tO\n$\tO\n599\tO\nthat\tO\nthis\tO\nlittle\tO\nguy\tO\nsells\tO\nfor\tO\n,\tO\nwhich\tO\nleaves\tO\nme\tO\nto\tO\nmy\tO\nnext\tO\npoint\tO\n.\tO\n\nthis\tO\nis\tO\nquite\tO\nsmooth\tO\nas\tO\nwell\tO\nas\tO\nheavy\tO\nand\tO\ncan\tO\neasily\tO\nslip\tO\nthrough\tO\nthe\tO\nhands\tO\n.\tO\n\nMy\tO\nlaptop\tO\nis\tO\nso\tO\nlight\tO\nthat\tO\nI\tO\ncan\tO\ntake\tO\nit\tO\nwith\tO\nme\tO\nanywhere\tO\n.\tO\n\nit\tO\n's\tO\nexactly\tO\nwhat\tO\ni\tO\nwanted\tO\n,\tO\nand\tO\nit\tO\nhas\tO\nall\tO\nthe\tO\nnew\tO\nfeatures\tB-aspectTerm\nand\tO\nwhatnot\tO\n.\tO\n\nYou\tO\ncan\tO\ndo\tO\nabsolutely\tO\nanything\tO\nand\tO\nis\tO\nvery\tO\nfast\tO\nand\tO\nstylish\tO\n.\tO\n\nFinally\tO\ndecided\tO\nto\tO\ntry\tO\na\tO\nMAC\tO\nbecause\tO\nthere\tO\nwere\tO\ntoo\tO\nmany\tO\nchoices\tO\nof\tO\nwhich\tO\nPC\tO\n's\tO\nto\tO\nbuy\tO\nand\tO\nEVERYONE\tO\nwho\tO\nhad\tO\na\tO\nMAC\tO\nsaid\tO\n\"\tO\nbuy\tO\na\tO\nMAC\tO\n\"\tO\n.\tO\n\nCan\tO\nyou\tO\nbuy\tO\nany\tO\nlaptop\tO\nthat\tO\nmatches\tO\nthe\tO\nquality\tB-aspectTerm\nof\tO\na\tO\nMacBook\tO\n?\tO\n\nIt\tO\nfeels\tO\ncheap\tO\n,\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\nnot\tO\nvery\tO\nsensitive\tO\n.\tO\n\nThat\tO\ndefeated\tO\nthe\tO\nwhole\tO\npoint\tO\nof\tO\na\tO\nlaptop\tO\n.\tO\n\nThough\tO\nplease\tO\nnote\tO\nthat\tO\nsometimes\tO\nit\tO\ncrashes\tO\n,\tO\nand\tO\nthe\tO\nsound\tB-aspectTerm\nquality\tI-aspectTerm\nis\tO\nnt\tO\nsuperb\tO\n.\tO\n\nIt\tO\nis\tO\nvery\tO\neasy\tO\nto\tO\nnavigate\tB-aspectTerm\neven\tO\nfor\tO\na\tO\nnovice\tO\n.\tO\n\nBut\tO\nuntil\tO\nnow\tO\n,\tO\nno\tO\ncomplains\tO\nat\tO\nall\tO\n.\tO\n\nThe\tO\ncons\tO\nare\tO\nmore\tO\nannoyances\tO\nthat\tO\ncan\tO\nbe\tO\nlived\tO\nwith\tO\n.\tO\n\nDoes\tO\neverything\tO\nI\tO\nneed\tO\nit\tO\nto\tO\n,\tO\nhas\tO\na\tO\nwonderful\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nand\tO\nI\tO\ncould\tO\nn't\tO\nbe\tO\nhappier\tO\n.\tO\n\nGreat\tO\nPerformance\tB-aspectTerm\nand\tO\nQuality\tB-aspectTerm\n.\tO\n\nJust\tO\nWhat\tO\nI\tO\nNeeded\tO\nFor\tO\nPortable\tO\nAnd\tO\nMy\tO\nWallet\tO\nToo\tO\n!\tO\n\nThe\tO\ndevice\tO\nspeaks\tO\nabout\tO\nit\tO\nself\tO\n.\tO\n\nI\tO\nused\tO\nwindows\tB-aspectTerm\nXP\tI-aspectTerm\n,\tO\nwindows\tB-aspectTerm\nVista\tI-aspectTerm\n,\tO\nand\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nextensively\tO\n.\tO\n\nthe\tO\nonly\tO\nthing\tO\nthat\tO\nbums\tO\nme\tO\nout\tO\nabout\tO\nthis\tO\npurchase\tO\nis\tO\nthey\tO\nreleased\tO\na\tO\nnewer\tO\nupdated\tO\nmbp\tO\nseriously\tO\nRIGHT\tO\nafter\tO\ni\tO\nbought\tO\nthis\tO\none\tO\n.\tO\n\nit\tO\ndoes\tO\nget\tO\nhot\tO\nwhen\tO\nusing\tO\non\tO\na\tO\nbed\tO\nor\tO\nsofa\tO\nand\tO\ngets\tO\nwarm\tO\non\tO\na\tO\ndesk\tO\n....\tO\nthis\tO\nis\tO\nin\tO\nan\tO\nun\tO\n-\tO\nair\tO\nconditioned\tO\nroom\tO\n.....\tO\nin\tO\nair\tO\ncondition\tO\nit\tO\ngets\tO\nslightly\tO\nwarm\tO\n......\tO\n\nI\tO\ndid\tO\nadd\tO\na\tO\nSSD\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nmemory\tB-aspectTerm\n\nI\tO\ngot\tO\nthis\tO\none\tO\nfor\tO\nthanks\tO\ngiving\tO\nOffer\tO\nfor\tO\n$\tO\n962\tO\n:)\tO\n.\tO\n\nI\tO\nhad\tO\nmy\tO\nPC\tO\nlaptop\tO\nfor\tO\n3\tO\nyears\tO\nand\tO\ngoing\tO\nto\tO\na\tO\nMacBook\tO\nPro\tO\nis\tO\nlike\tO\nI\tO\nleaped\tO\nthrough\tO\ntime\tO\n.\tO\n\nOn\tO\nstart\tB-aspectTerm\nup\tI-aspectTerm\nit\tO\nasks\tO\nendless\tO\nquestions\tO\njust\tO\nso\tO\nitune\tB-aspectTerm\ncan\tO\nsell\tO\nyou\tO\nmore\tO\nof\tO\ntheir\tO\nproducts\tO\n.\tO\n\nPretty\tO\nmuch\tO\nmade\tO\nsense\tO\nto\tO\nget\tO\na\tO\nMini\tO\n.\tO\n\nI\tO\nHave\tO\nbeen\tO\na\tO\nPc\tO\nuser\tO\nfor\tO\na\tO\nvery\tO\nlong\tO\ntime\tO\nnow\tO\nbut\tO\nI\tO\nwill\tO\nget\tO\nused\tO\nto\tO\nthis\tO\nnew\tO\nOS\tB-aspectTerm\n.\tO\n\nnot\tO\nsomething\tO\nyou\tO\nwant\tO\nto\tO\nmiss\tO\nout\tO\non\tO\n!\tO\n!\tO\n!\tO\n\nOne\tO\nmore\tO\nthing\tO\n,\tO\nthis\tO\nmac\tO\ndoes\tO\nNOT\tO\ncome\tO\nwith\tO\nrestore\tB-aspectTerm\ndisks\tI-aspectTerm\nand\tO\nI\tO\nam\tO\nnot\tO\nsure\tO\nif\tO\nyou\tO\ncan\tO\nmake\tO\nthem\tO\ndirect\tO\nfrom\tO\nthe\tO\nmac\tO\nlike\tO\nyou\tO\ncan\tO\nwith\tO\nnewer\tO\nPC\tO\n's\tO\n,\tO\nalso\tO\nthe\tO\ncharging\tB-aspectTerm\ncables\tI-aspectTerm\nare\tO\nmade\tO\nof\tO\nthe\tO\nsame\tO\ncheap\tO\nmaterial\tB-aspectTerm\nas\tO\nthe\tO\niPhone\tO\n/\tO\niPod\tO\ntouch\tO\ncables\tO\n.\tO\n\nI\tO\nbought\tO\nit\tO\nto\tO\nmy\tO\nson\tO\nwho\tO\nuses\tO\nit\tO\nfor\tO\ngraphic\tB-aspectTerm\ndesign\tI-aspectTerm\n.\tO\n\nI\tO\npreviously\tO\nowned\tO\nan\tO\nolder\tO\nDell\tO\nlaptop\tO\nthat\tO\ndied\tO\nafter\tO\nabout\tO\n5\tO\nor\tO\n6\tO\nyears\tO\n.\tO\n\nIts\tO\na\tO\npretty\tO\ndecent\tO\ncomputer\tO\n.\tO\n\nI\tO\nnever\tO\ntried\tO\nany\tO\nexternal\tB-aspectTerm\nmics\tI-aspectTerm\nwith\tO\nthat\tO\niMac\tO\n.\tO\n\nThe\tO\nnew\tO\nos\tB-aspectTerm\nis\tO\ngreat\tO\non\tO\nmy\tO\nmacbook\tO\npro\tO\n!\tO\n\nIt\tO\nwas\tO\nfast\tO\n,\tO\nand\tO\nit\tO\nwas\tO\n\"\tO\ndifferent\tO\n\"\tO\n.\tO\n\nI\tO\nhad\tO\na\tO\nlittle\tO\nproblem\tO\nadjusting\tO\nto\tO\nthe\tO\nsmall\tO\nscreen\tB-aspectTerm\nbut\tO\nworks\tO\nfine\tO\nas\tO\nlong\tO\nas\tO\nI\tO\nremember\tO\nto\tO\ncarry\tO\nmy\tO\nglasses\tO\n.\tO\n\nI\tO\npurchased\tO\nmy\tO\nfirst\tO\nMac\tO\nand\tO\nam\tO\nglad\tO\nI\tO\ndid\tO\n.\tO\n\nI\tO\nhave\tO\nexperienced\tO\nno\tO\nproblems\tO\n,\tO\nworks\tB-aspectTerm\nas\tO\nanticipated\tO\n.\tO\n\nSystem\tB-aspectTerm\nis\tO\nrunning\tO\ngreat\tO\n.\tO\n\nEasy\tO\nto\tO\ncustomize\tB-aspectTerm\nsetting\tI-aspectTerm\nand\tO\neven\tO\ncreate\tB-aspectTerm\nyour\tI-aspectTerm\nown\tI-aspectTerm\nbookmarks\tI-aspectTerm\n.\tO\n\nThey\tO\nreally\tO\nscrewed\tO\nthe\tO\npooch\tO\non\tO\nthis\tO\none\tO\n.\tO\n\nThe\tO\nMAC\tO\nMini\tO\n,\tO\nwireless\tB-aspectTerm\nkeyboard\tI-aspectTerm\n/\tI-aspectTerm\nmouse\tI-aspectTerm\nand\tO\na\tO\nHDMI\tB-aspectTerm\ncable\tI-aspectTerm\nis\tO\nall\tO\nI\tO\nneed\tO\nto\tO\nget\tO\nsome\tO\nreal\tO\nwork\tO\ndone\tO\n.\tO\n\nI\tO\nfinally\tO\npulled\tO\nthe\tO\ntrigger\tO\nand\tO\nI\tO\nam\tO\nblown\tO\naway\tO\nby\tO\nhow\tO\nmuch\tO\nmore\tO\nI\tO\nenjoy\tO\nmy\tO\ncomputer\tO\ntasks\tO\nusing\tO\nthe\tO\nMac\tO\nMini\tO\n!\tO\n!\tO\n!\tO\n\nit\tO\nhas\tO\nall\tO\nthe\tO\nfeatures\tB-aspectTerm\nthat\tO\nwe\tO\nexpected\tO\nand\tO\nthe\tO\nprice\tB-aspectTerm\nwas\tO\ngood\tO\n,\tO\nworking\tB-aspectTerm\nwell\tO\nso\tO\nfar\tO\n.\tO\n\nI\tO\nwork\tO\nas\tO\na\tO\ndesigner\tO\nand\tO\ncoder\tO\nand\tO\nI\tO\nneeded\tO\na\tO\nnew\tO\nbuddy\tO\nto\tO\nwork\tO\nwith\tO\n,\tO\nnot\tO\ngaming\tB-aspectTerm\n.\tO\n\nI\tO\nwas\tO\ntold\tO\nthat\tO\nit\tO\nseems\tO\nto\tO\nbe\tO\na\tO\nmulti\tO\n-\tO\ncomponent\tO\nfailure\tO\n.\tO\n\nThe\tO\nnew\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nmakes\tO\nthis\tO\ncomputer\tO\ninto\tO\na\tO\nsuper\tO\niPad\tO\n.\tO\n\nI\tO\nam\tO\nvery\tO\nhappy\tO\nwith\tO\nmy\tO\nfirst\tO\nMac\tO\n.\tO\n\nEasy\tO\nto\tO\nset\tB-aspectTerm\nup\tI-aspectTerm\nand\tO\ngo\tO\n!\tO\n\nI\tO\nca\tO\nn't\tO\nbelieve\tO\nhow\tO\nquiet\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nis\tO\nand\tO\nhow\tO\nquick\tO\nthis\tO\nthing\tO\nboots\tB-aspectTerm\nup\tI-aspectTerm\n.\tO\n\nThe\tO\nonly\tO\nissue\tO\ncame\tO\nwhen\tO\nI\tO\ntried\tO\nscanning\tB-aspectTerm\nto\tO\nthe\tO\nmac\tO\n.\tO\n\nThe\tO\nmachine\tO\nis\tO\nspeedy\tO\nand\tO\nefficient\tO\n.\tO\n\nI\tO\nthink\tO\nthis\tO\nis\tO\nabout\tO\nas\tO\ngood\tO\nas\tO\nit\tO\ngets\tO\nat\tO\nanything\tO\nclose\tO\nto\tO\nthis\tO\nprice\tB-aspectTerm\npoint\tI-aspectTerm\n.\tO\n\nA\tO\n*\tO\nbig\tO\n*\tO\nupgrade\tO\nfrom\tO\nmy\tO\n13\tO\n\"\tO\n2006\tO\nmacbook\tO\n.\tO\n\nIt\tO\n's\tO\njust\tO\nwhat\tO\nwe\tO\nwere\tO\nlooking\tO\nfor\tO\nand\tO\nit\tO\nworks\tB-aspectTerm\ngreat\tO\n.\tO\n\nHaving\tO\na\tO\nMac\tO\ncertainly\tO\nmakes\tO\nlife\tO\neasier\tO\n.\tO\n\nIt\tO\n's\tO\nso\tO\nquick\tO\nand\tO\nresponsive\tO\nthat\tO\nit\tO\nmakes\tO\nworking\tB-aspectTerm\n/\tO\nsurfing\tB-aspectTerm\non\tO\na\tO\ncomputer\tO\nso\tO\nmuch\tO\nmore\tO\npleasurable\tO\n!\tO\n\nThe\tO\nold\tO\nunibody\tO\nmacbook\tO\npro\tO\ncould\tO\nfry\tO\nan\tO\negg\tO\nafter\tO\na\tO\nwhile\tO\n.\tO\n\nIt\tO\nworks\tB-aspectTerm\nfine\tO\n,\tO\nand\tO\nall\tO\nthe\tO\nsoftware\tB-aspectTerm\nseems\tO\nto\tO\nrun\tO\npretty\tO\nwell\tO\n.\tO\n\nFor\tO\nthis\tO\npurpose\tO\n,\tO\nit\tO\n's\tO\ngreat\tO\n.\tO\n\nCould\tO\nn't\tO\nhave\tO\nasked\tO\nfor\tO\nmore\tO\n!\tO\n\nI\tO\n'm\tO\nusing\tO\nthis\tO\ncomputer\tO\nfor\tO\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\n,\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\n,\tO\nsome\tO\ngaming\tB-aspectTerm\n,\tO\nand\tO\nI\tO\n'm\tO\nlearning\tO\nprogramming\tB-aspectTerm\n.\tO\n\nIt\tO\ncertainly\tO\ndoes\tO\n,\tO\nbut\tO\nyou\tO\nrarely\tO\nhear\tO\nany\tO\nof\tO\nyour\tO\nfriends\tO\nwith\tO\nMac\tO\n's\tO\ncomplain\tO\nabout\tO\nanything\tO\n.\tO\n\nMy\tO\nwife\tO\nwas\tO\nso\tO\nexcited\tO\nto\tO\nopen\tO\nthe\tO\nbox\tO\n,\tO\nbut\tO\nquickly\tO\ncame\tO\nto\tO\nsee\tO\nthat\tO\nit\tO\ndid\tO\nnot\tO\nfunction\tB-aspectTerm\nas\tO\nit\tO\nshould\tO\n.\tO\n\nI\tO\ndo\tO\nn't\tO\nhave\tO\nany\tO\ntechnical\tO\npearls\tO\nto\tO\nshare\tO\n.\tO\n\nI\tO\nwanted\tO\na\tO\ncomputer\tO\nthat\tO\nwas\tO\nquite\tO\n,\tO\nfast\tO\n,\tO\nand\tO\nthat\tO\nhad\tO\noverall\tO\ngreat\tO\nperformance\tB-aspectTerm\n.\tO\n\nApple\tB-aspectTerm\n\"\tI-aspectTerm\nHelp\tI-aspectTerm\n\"\tI-aspectTerm\nis\tO\na\tO\nmixed\tO\nbag\tO\n.\tO\n\nAll\tO\nI\tO\ncan\tO\nsay\tO\nis\tO\nI\tO\nam\tO\nimpressed\tO\n.\tO\n\nIt\tO\nsuddenly\tO\ncan\tO\nnot\tO\nwork\tB-aspectTerm\n.\tO\n\nIt\tO\ndid\tO\neverything\tO\nwe\tO\nexpected\tO\n!\tO\n\nHarddrive\tB-aspectTerm\nwas\tO\nin\tO\npoor\tO\ncondition\tO\n,\tO\nhad\tO\nto\tO\nreplace\tO\nit\tO\n.\tO\n\nThe\tO\non\tB-aspectTerm\n/\tI-aspectTerm\noff\tI-aspectTerm\nswitch\tI-aspectTerm\nis\tO\na\tO\nbit\tO\nobscure\tO\nin\tO\nthe\tO\nrear\tO\ncorner\tO\n.\tO\n\nIt\tO\n's\tO\na\tO\nnice\tO\nlittle\tO\ngadget\tO\n.\tO\n\nMy\tO\nonly\tO\ncomplaint\tO\nis\tO\nthe\tO\ntotal\tO\nlack\tO\nof\tO\ninstructions\tB-aspectTerm\nthat\tO\ncome\tO\nwith\tO\nthe\tO\nmac\tO\nmini\tO\n.\tO\n\nThe\tO\nonly\tO\ntask\tO\nthat\tO\nthis\tO\ncomputer\tO\nwould\tO\nnot\tO\nbe\tO\ngood\tO\nenough\tO\nfor\tO\nwould\tO\nbe\tO\ngaming\tB-aspectTerm\n,\tO\notherwise\tO\nthe\tO\nintegrated\tB-aspectTerm\nIntel\tI-aspectTerm\n4000\tI-aspectTerm\ngraphics\tI-aspectTerm\nwork\tO\nwell\tO\nfor\tO\nother\tO\ntasks\tO\n.\tO\n\nIt\tO\n's\tO\nmacbook\tO\npro\tO\nand\tO\nthere\tO\nis\tO\nno\tO\ndiscusion\tO\nabout\tO\nit\tO\n.\tO\n\nI\tO\n'm\tO\nhoping\tO\nthe\tO\nrest\tO\nof\tO\nthe\tO\nfeatures\tB-aspectTerm\nwill\tO\nbe\tO\nthe\tO\nsignature\tO\nquality\tO\nof\tO\napple\tO\n.\tO\n\nI\tO\nuse\tO\nit\tO\nmostly\tO\nfor\tO\ncontent\tB-aspectTerm\ncreation\tI-aspectTerm\n(\tO\nAudio\tB-aspectTerm\n,\tO\nvideo\tB-aspectTerm\n,\tO\nphoto\tB-aspectTerm\nediting\tI-aspectTerm\n)\tO\nand\tO\nits\tO\nreliable\tO\n.\tO\n\nIt\tO\nis\tO\nthe\tO\nbest\tO\nall\tO\naround\tO\nMac\tO\n.\tO\n\nScreen\tB-aspectTerm\nis\tO\nbright\tO\nand\tO\ngorgeous\tO\n.\tO\n\nAlso\tO\nis\tO\nportable\tO\nand\tO\nreliable\tO\n.\tO\n\nThe\tO\nonly\tO\nsolution\tO\nis\tO\nto\tO\nturn\tO\nthe\tO\nbrightness\tB-aspectTerm\ndown\tO\n,\tO\netc\tO\n.\tO\n\nIt\tO\nis\tO\nnot\tO\nan\tO\neasy\tO\ndecision\tO\nto\tO\npurchase\tO\na\tO\nused\tO\nor\tO\neven\tO\ngood\tO\nas\tO\nnew\tO\nlaptop\tO\nbut\tO\nI\tO\nam\tO\nvery\tO\nsatisfied\tO\n.\tO\n\nIf\tO\nyou\tO\nwant\tO\nmore\tO\ninformation\tO\non\tO\nmacs\tO\nI\tO\nsuggest\tO\ngoing\tO\nto\tO\napple.com\tO\nand\tO\nheading\tO\ntowards\tO\nthe\tO\nmacbook\tO\npage\tO\nfor\tO\nmore\tO\ninformation\tO\non\tO\nthe\tO\napplications\tB-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nrobust\tO\n,\tO\nwith\tO\na\tO\nfriendly\tO\nuse\tB-aspectTerm\nas\tO\nall\tO\nApple\tO\nproducts\tO\n.\tO\n\nEven\tO\nif\tO\nyou\tO\ndo\tO\nn't\tO\ndo\tO\nbusiness\tO\n,\tO\nthat\tO\ns\tO\nokay\tO\n,\tO\nit\tO\n's\tO\nincredibly\tO\nfast\tO\n.\tO\n\nIt\tO\nis\tO\nfast\tO\nand\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nThis\tO\nwas\tO\nabsolutely\tO\nannoying\tO\n!\tO\n\nAnd\tO\nthe\tO\nfact\tO\nthat\tO\nit\tO\ncomes\tO\nwith\tO\nan\tO\ni5\tB-aspectTerm\nprocessor\tI-aspectTerm\ndefinitely\tO\nspeeds\tO\nthings\tO\nup\tO\n\nBut\tO\nfor\tO\nthose\tO\nof\tO\nyou\tO\nthat\tO\ndo\tO\nnt\tO\nhave\tO\na\tO\nmac\tO\nand\tO\nare\tO\nstill\tO\non\tO\nthe\tO\nPC\tO\n's\tO\nthis\tO\nis\tO\na\tO\ngood\tO\nfoot\tO\nin\tO\nthe\tO\ndoor\tO\ninto\tO\nmac\tO\n.\tO\n\nI\tO\nhave\tO\nbeen\tO\nPC\tO\nfor\tO\nyears\tO\nbut\tO\nthis\tO\ncomputer\tO\nis\tO\nintuitive\tO\nand\tO\nits\tO\nbuilt\tB-aspectTerm\nin\tI-aspectTerm\nfeatures\tI-aspectTerm\nare\tO\na\tO\ngreat\tO\nhelp\tO\n\nand\tO\nit\tO\nfits\tO\nin\tO\nmy\tO\nbriefcase\tO\nwith\tO\nease\tO\n\nNice\tO\nscreen\tB-aspectTerm\n,\tO\nkeyboard\tB-aspectTerm\nworks\tO\ngreat\tO\n!\tO\n\nStill\tO\nnot\tO\nbad\tO\nfor\tO\n220.00\tO\n.\tO\n\nI\tO\nwas\tO\namazed\tO\nat\tO\nhow\tO\nfast\tO\nthe\tO\ndelivery\tB-aspectTerm\nwas\tO\n.\tO\n\nGood\tO\ncomputer\tO\nand\tO\nfast\tO\n.\tO\n\nI\tO\n've\tO\ninstalled\tO\nto\tO\nit\tO\nadditional\tO\nSSD\tB-aspectTerm\nand\tO\n16Gb\tB-aspectTerm\nRAM\tI-aspectTerm\n.\tO\n\nThe\tO\nmemory\tB-aspectTerm\nwas\tO\ngone\tO\nand\tO\nit\tO\nwas\tO\nnot\tO\nable\tO\nto\tO\nbe\tO\nused\tO\n.\tO\n\nIts\tO\npretty\tO\nmuch\tO\nfire\tO\nit\tO\nup\tO\nand\tO\ngo\tO\n.\tO\n\nIt\tO\nworks\tB-aspectTerm\ngreat\tO\nand\tO\nI\tO\nam\tO\nso\tO\nhappy\tO\nI\tO\nbought\tO\nit\tO\n.\tO\n\nLet\tO\nme\tO\nstart\tO\noff\tO\nby\tO\nsaying\tO\nthat\tO\nI\tO\nwas\tO\nhighly\tO\nreluctant\tO\nto\tO\nspend\tO\nso\tO\nmuch\tO\nmoney\tO\non\tO\na\tO\nlaptop\tO\n.\tO\n\nI\tO\nlike\tO\nthe\tO\ndesign\tB-aspectTerm\nand\tO\nease\tO\nof\tO\nuse\tO\nwith\tO\nthe\tO\nkeyboard\tB-aspectTerm\n,\tO\nplenty\tO\nof\tO\nports\tB-aspectTerm\n.\tO\n\nApple\tO\nis\tO\nliving\tO\nup\tO\nto\tO\nits\tO\nname\tO\nwith\tO\nthe\tO\nmini\tO\nand\tO\n,\tO\nfor\tO\nour\tO\nneeds\tO\n,\tO\nit\tO\n's\tO\nperfect\tO\n.\tO\n\nit\tO\ndefinitely\tO\nbeats\tO\nmy\tO\nold\tO\nmac\tO\nand\tO\nthe\tO\nservice\tB-aspectTerm\nwas\tO\ngreat\tO\n.\tO\n\nI\tO\nwent\tO\nfrom\tO\na\tO\nMacbook\tO\nto\tO\nthis\tO\nMac\tO\nMini\tO\nand\tO\nthis\tO\nwas\tO\na\tO\ngreat\tO\nupgrade\tO\n!\tO\n\nWeb\tB-aspectTerm\nbrowsing\tI-aspectTerm\nis\tO\nvery\tO\nquick\tO\nwith\tO\nSafari\tB-aspectTerm\nbrowser\tI-aspectTerm\n.\tO\n\nIt\tO\ncould\tO\nn't\tO\nhave\tO\nbeen\tO\na\tO\nbetter\tO\ndecision\tO\n.\tO\n\nI\tO\nlike\tO\nthe\tO\nlighted\tB-aspectTerm\nscreen\tI-aspectTerm\nat\tO\nnight\tO\n.\tO\n\nIt\tO\n's\tO\ngreat\tO\nto\tO\nhave\tO\na\tO\nsolid\tO\nMac\tO\nin\tO\nthe\tO\nliving\tO\nroom\tO\n.\tO\n\nIt\tO\nis\tO\nreally\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nit\tO\nis\tO\nquick\tO\nto\tO\nstart\tB-aspectTerm\nup\tI-aspectTerm\n.\tO\n\nI\tO\n've\tO\nlived\tO\nwith\tO\nthe\tO\ncrashes\tO\nand\tO\nslow\tO\noperation\tB-aspectTerm\nand\tO\nrestarts\tO\n.\tO\n\nVery\tO\nlight\tO\nand\tO\neasily\tO\nmaneuverable\tO\n.\tO\n\nUSB3\tB-aspectTerm\nPeripherals\tI-aspectTerm\nare\tO\nnoticably\tO\nless\tO\nexpensive\tO\nthan\tO\nthe\tO\nThunderBolt\tB-aspectTerm\nones\tO\n.\tO\n\nThis\tO\ncan\tO\nbe\tO\nannoying\tO\nat\tO\nfirst\tO\nbut\tO\nyou\tO\njust\tO\nhave\tO\nto\tO\ntrain\tO\nyourself\tO\nnot\tO\nto\tO\nto\tO\nstart\tO\nover\tO\nso\tO\nfar\tO\n.\tO\n\nAnd\tO\nmine\tO\nhad\tO\nbroke\tO\nbut\tO\nI\tO\nsent\tO\nit\tO\nin\tO\nunder\tO\nwarranty\tB-aspectTerm\n-\tO\nno\tO\nproblems\tO\n.\tO\n\nI\tO\nam\tO\nnot\tO\nhappy\tO\nwith\tO\nmy\tO\npurchase\tO\n\nIt\tO\n's\tO\nfast\tO\n,\tO\nlight\tO\n,\tO\nand\tO\nis\tO\nperfect\tO\nfor\tO\nmedia\tB-aspectTerm\nediting\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\nmostly\tO\nwhy\tO\nI\tO\nbought\tO\nit\tO\nin\tO\nthe\tO\nfirst\tO\nplace\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmachine\tO\nitself\tO\nleft\tO\na\tO\nbit\tO\nto\tO\nbe\tO\ndesired\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlasts\tO\nas\tO\nadvertised\tO\n(\tO\ngive\tO\nor\tO\ntake\tO\n15\tO\n-\tO\n20\tO\nminutes\tO\n)\tO\n,\tO\nand\tO\nthe\tO\nentire\tO\nuser\tB-aspectTerm\nexperience\tI-aspectTerm\nis\tO\nvery\tO\nelegant\tO\n.\tO\n\nI\tO\nspent\tO\nmonths\tO\nlooking\tO\nfor\tO\na\tO\ngood\tO\nlaptop\tO\nfor\tO\nme\tO\nand\tO\nI\tO\nfinally\tO\nfound\tO\nit\tO\n!\tO\n\n$\tO\n999.00\tO\nTax\tO\nfree\tO\n.\tO\n\nThanks\tO\nfor\tO\nthe\tO\nfast\tO\nshipment\tB-aspectTerm\nand\tO\ngreat\tO\nprice\tB-aspectTerm\n.\tO\n\n!\tO\nExcelent\tO\nperformance\tB-aspectTerm\n,\tO\nusability\tB-aspectTerm\n,\tO\npresentation\tB-aspectTerm\nand\tO\ntime\tB-aspectTerm\nresponse\tI-aspectTerm\n.\tO\n\nThe\tO\nsmaller\tO\nsize\tB-aspectTerm\nwas\tO\na\tO\nbonus\tO\nbecause\tO\nof\tO\nspace\tO\nrestrictions\tO\n.\tO\n\nI\tO\nblame\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\n.\tO\n\nBut\tO\nfor\tO\nnow\tO\n,\tO\nthis\tO\nlaptop\tO\nis\tO\nstill\tO\na\tO\nworkhorse\tO\n.\tO\n\nIn\tO\nfact\tO\nI\tO\nstill\tO\nuse\tO\nmanyLegacy\tO\nprograms\tB-aspectTerm\n(\tO\nAppleworks\tB-aspectTerm\n,\tO\nFileMaker\tB-aspectTerm\nPro\tI-aspectTerm\n,\tO\nQuicken\tB-aspectTerm\n,\tO\nPhotoshop\tB-aspectTerm\netc\tO\n)\tO\n!\tO\n\nIt\tO\n's\tO\nsmall\tO\nbut\tO\npowerful\tO\n,\tO\nlight\tO\nbut\tO\nstrong\tO\n,\tO\nelegant\tO\nand\tO\nbeautiful\tO\n...\tO\nIn\tO\nresume\tO\n:\tO\nit\tO\n's\tO\na\tO\nMac\tO\n!\tO\n\nI\tO\nlike\tO\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n.\tO\n\nI\tO\nwish\tO\nI\tO\nwould\tO\nhave\tO\ntaken\tO\nthe\tO\nplunge\tO\nyears\tO\nago\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nform\tB-aspectTerm\nfactor\tI-aspectTerm\n.\tO\n\nI\tO\nhave\tO\nn't\tO\nused\tO\nthe\tO\nproduct\tO\nlong\tO\nenough\tO\nto\tO\nwrite\tO\na\tO\ndetailed\tO\ntechnical\tO\nreview\tO\n.\tO\n\nIt\tO\n's\tO\nfast\tO\nat\tO\nloading\tB-aspectTerm\nthe\tI-aspectTerm\ninternet\tI-aspectTerm\n.\tO\n\nSo\tO\nmuch\tO\nfaster\tO\nand\tO\nsleeker\tO\nlooking\tB-aspectTerm\n.\tO\n\nI\tO\nplan\tO\non\tO\nusing\tO\nmy\tO\nMacBook\tO\nPro\tO\nfor\tO\na\tO\nlong\tO\ntime\tO\n.\tO\n\nUnfortunately\tO\n,\tO\nit\tO\nruns\tO\nXP\tB-aspectTerm\nand\tO\nMicrosoft\tO\nis\tO\ndropping\tO\nsupport\tB-aspectTerm\nnext\tO\nApril\tO\n.\tO\n\nIts\tO\nseen\tO\nin\tO\nmovies\tO\n,\tO\nsitcoms\tO\n,\tO\nprominent\tO\nimportant\tO\npeople\tO\ncarry\tO\nand\tO\nuse\tO\nthem\tO\nand\tO\nthey\tO\nare\tO\nGREAT\tO\n!\tO\n\nFirst\tO\noff\tO\n,\tO\nI\tO\nreally\tO\ndo\tO\nlike\tO\nmy\tO\nMBP\tO\n...\tO\nonce\tO\nused\tO\nto\tO\nthe\tO\nOS\tB-aspectTerm\nit\tO\nis\tO\npretty\tO\neasy\tO\nto\tO\nget\tO\naround\tO\n,\tO\nand\tO\nthe\tO\noverall\tB-aspectTerm\nbuild\tI-aspectTerm\nis\tO\ngreat\tO\n...\tO\neg\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\none\tO\nof\tO\nthe\tO\nbest\tO\nto\tO\ntype\tO\non\tO\n.\tO\n\nDoes\tO\nexactly\tO\nwhat\tO\nI\tO\nbought\tO\nit\tO\n4\tO\n.\tO\n\nBuy\tO\nthe\tO\nMac\tO\nMini\tO\nit\tO\n's\tO\na\tO\nterribly\tO\ngreat\tO\nmachine\tO\n.\tO\n\nIt\tO\nis\tO\nmade\tO\nof\tO\nsuch\tO\nsolid\tO\nconstruction\tB-aspectTerm\nand\tO\nsince\tO\nI\tO\nhave\tO\nnever\tO\nhad\tO\na\tO\nMac\tO\nusing\tO\nmy\tO\niPhone\tO\nhelped\tO\nme\tO\nget\tO\nused\tO\nto\tO\nthe\tO\nsystem\tB-aspectTerm\na\tO\nbit\tO\n.\tO\n\nI\tO\nlove\tO\nthis\tO\npiece\tO\nof\tO\nequipment\tO\n,\tO\nIt\tO\nwill\tO\nbe\tO\nhard\tO\nto\tO\ngo\tO\nback\tO\nto\tO\nother\tO\ntype\tO\nof\tO\nlaptop\tO\nafter\tO\nusing\tO\na\tO\nMacBook\tO\nPro\tO\n.\tO\n\nVery\tO\nnice\tO\nunibody\tB-aspectTerm\nconstruction\tI-aspectTerm\n.\tO\n\nVery\tO\ndisappointed\tO\nwith\tO\nApple\tO\n.\tO\n\nThis\tO\nMacbook\tO\nPro\tO\nis\tO\nfast\tO\n,\tO\npowerful\tO\n,\tO\nand\tO\nruns\tB-aspectTerm\nsuper\tO\nquiet\tO\nand\tO\ncool\tO\n.\tO\n\n*\tO\n*\tO\n*\tO\nThe\tO\nreview\tO\nbelow\tO\nis\tO\nno\tO\nlonger\tO\nrelevant\tO\n,\tO\nApple\tO\nhas\tO\nfixed\tO\nthe\tO\nissue\tO\n.\tO\n\nIt\tO\n's\tO\nok\tO\nbut\tO\ndoes\tO\nn't\tO\nhave\tO\na\tO\ndisk\tB-aspectTerm\ndrive\tI-aspectTerm\nwhich\tO\nI\tO\ndid\tO\nn't\tO\nknow\tO\nuntil\tO\nafter\tO\nI\tO\nbought\tO\nit\tO\n.\tO\n\nThere\tO\nis\tO\nno\tO\nHDMI\tB-aspectTerm\nreceptacle\tI-aspectTerm\n,\tO\nnor\tO\nis\tO\nthere\tO\nan\tO\nSD\tB-aspectTerm\ncard\tI-aspectTerm\nslot\tI-aspectTerm\nlocated\tO\nanywhere\tO\non\tO\nthe\tO\ndevice\tO\n.\tO\n\nIt\tO\nreally\tO\nis\tO\nvery\tO\nlight\tO\ncompared\tO\nto\tO\nother\tO\ncomputers\tO\n.\tO\n\nIt\tO\ncame\tO\nin\tO\nbrand\tO\nnew\tO\nand\tO\nworks\tB-aspectTerm\nperfectly\tO\n.\tO\n\nThis\tO\nmachine\tO\nis\tO\nA\tO\n-\tO\nmazing\tO\n.\tO\n\nIt\tO\nshould\tO\nn't\tO\nhappen\tO\nlike\tO\nthat\tO\n,\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nany\tO\ndesign\tB-aspectTerm\napp\tI-aspectTerm\nopen\tO\nor\tO\nanything\tO\n.\tO\n\nMY\tO\nTRACKPAD\tB-aspectTerm\nIS\tO\nNOT\tO\nWORKING\tO\n.\tO\n\nI\tO\njust\tO\nhope\tO\nthis\tO\nexpensive\tO\nlaptop\tO\ndoes\tO\nn't\tO\ngo\tO\ndead\tO\nlike\tO\nmy\tO\nfriends\tO\n...\tO\nit\tO\ndid\tO\nlast\tO\nhim\tO\n5\tO\ngood\tO\nyears\tO\nbefore\tO\nit\tO\nbit\tO\nthe\tO\ndust\tO\n.\tO\n\nConsidering\tO\nanother\tO\ncomputer\tO\nshould\tO\nbe\tO\nout\tO\nof\tO\nthe\tO\nquestion\tO\n\nIt\tO\nlooks\tB-aspectTerm\nand\tO\nfeels\tB-aspectTerm\nsolid\tO\n,\tO\nwith\tO\na\tO\nflawless\tO\nfinish\tB-aspectTerm\n.\tO\n\nIts\tO\nworth\tO\nevery\tO\nPenny\tO\n.\tO\n\nPrice\tB-aspectTerm\nwas\tO\nhigher\tO\nwhen\tO\npurchased\tO\non\tO\nMAC\tO\nwhen\tO\ncompared\tO\nto\tO\nprice\tB-aspectTerm\nshowing\tO\non\tO\nPC\tO\nwhen\tO\nI\tO\nbought\tO\nthis\tO\nproduct\tO\n.\tO\n\nThis\tO\nwas\tO\na\tO\ngreat\tO\ndeal\tO\nfor\tO\na\tO\ndecked\tO\nout\tO\nMacBook\tO\nPro\tO\n.\tO\n\nThen\tO\nthe\tO\nsystem\tB-aspectTerm\nwould\tO\nmany\tO\ntimes\tO\nnot\tO\npower\tB-aspectTerm\ndown\tI-aspectTerm\nwithout\tO\na\tO\nforced\tO\npower\tO\n-\tO\noff\tO\n.\tO\n\nGet\tO\nthis\tO\ninstead\tO\n,\tO\nyou\tO\nwo\tO\nn't\tO\nbe\tO\nsorry\tO\n.\tO\n\nThe\tO\nconfiguration\tB-aspectTerm\nis\tO\nperfect\tO\nfor\tO\nmy\tO\nneeds\tO\n.\tO\n\nand\tO\nthe\tO\nspeakers\tB-aspectTerm\nis\tO\nthe\tO\nworst\tO\never\tO\n.\tO\n\nI\tO\nthink\tO\nit\tO\nwas\tO\naround\tO\n16\tO\nhundred\tO\nbucks\tO\nlast\tO\nI\tO\nchecked\tO\n.\tO\n\nIts\tO\nthe\tO\nbest\tO\n,\tO\nits\tO\ngot\tO\nthe\tO\nlooks\tB-aspectTerm\n,\tO\nsuper\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nlove\tO\nall\tO\nyou\tO\ncan\tO\ndo\tO\nwith\tO\nthe\tO\ntrackpad\tB-aspectTerm\n!\tO\n..\tO\n\nIt\tO\n's\tO\nfast\tO\n,\tO\nquiet\tO\n,\tO\nincredibly\tO\nsmall\tO\nand\tO\naffordable\tO\ncompared\tO\nto\tO\nother\tO\nMac\tO\nmodels\tO\n.\tO\n\nWeb\tB-aspectTerm\nsurfuring\tI-aspectTerm\nis\tO\nsmooth\tO\nand\tO\nseamless\tO\n.\tO\n\nIt\tO\nwas\tO\nso\tO\nexciting\tO\nfor\tO\nme\tO\nto\tO\nunwrapp\tO\nmy\tO\nnew\tO\nmac\tO\n.\tO\n\nI\tO\n'm\tO\noverall\tO\npleased\tO\nwith\tO\nthe\tO\ninterface\tB-aspectTerm\nand\tO\nthe\tO\nportability\tB-aspectTerm\nof\tO\nthis\tO\nproduct\tO\n.\tO\n\nso\tO\nwhen\tO\nI\tO\nhad\tO\nthe\tO\nmoney\tO\nto\tO\nbuy\tO\none\tO\nI\tO\nbought\tO\nother\tO\nthings\tO\ninstead\tO\n....\tO\na\tO\n700\tO\nlaptop\tO\nand\tO\nsome\tO\nextra\tO\nstuff\tO\nwith\tO\nit\tO\n.\tO\n\nThis\tO\nitem\tO\nis\tO\na\tO\nbeautiful\tO\npiece\tO\n,\tO\nit\tO\nworks\tB-aspectTerm\nwell\tO\n,\tO\nit\tO\nis\tO\neasy\tO\nto\tO\ncarry\tB-aspectTerm\nand\tO\nhandle\tB-aspectTerm\n.\tO\n\nSee\tO\nretired\tO\nrecently\tO\nand\tO\ndecided\tO\nthat\tO\nshe\tO\nwanted\tO\na\tO\nlaptop\tO\n.\tO\n\nIt\tO\nwas\tO\nalso\tO\nsuffering\tO\nfrom\tO\nhardware\tB-aspectTerm\n(\tI-aspectTerm\nkeyboard\tI-aspectTerm\n)\tI-aspectTerm\nissues\tO\n,\tO\nrelatively\tO\nslow\tO\nperformance\tB-aspectTerm\nand\tO\nshortening\tO\nbattery\tB-aspectTerm\nlifetime\tI-aspectTerm\n.\tO\n\nI\tO\n'm\tO\nno\tO\nregular\tO\ncustomer\tO\nI\tO\nhate\tO\nwasting\tO\nmy\tO\ntime\tO\nwith\tO\nhellos\tO\nand\tO\nhow\tO\ncan\tO\nI\tO\nhelp\tO\nyou\tO\n's\tO\n.\tO\n\nRuns\tB-aspectTerm\ngood\tO\nand\tO\ndoes\tO\nthe\tO\njob\tO\n,\tO\nca\tO\nn't\tO\ncomplain\tO\nabout\tO\nthat\tO\n!\tO\n\nIt\tO\n's\tO\nsilent\tO\nand\tO\nhas\tO\na\tO\nvery\tO\nsmall\tO\nfootprint\tB-aspectTerm\non\tO\nmy\tO\ndesk\tO\n.\tO\n\nI\tO\nhave\tO\nnothing\tO\nto\tO\nregret\tO\nfrom\tO\nthis\tO\nnew\tO\nproduct\tO\n.\tO\n\nThe\tO\nexterior\tB-aspectTerm\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nHave\tO\none\tO\nmyself\tO\nand\tO\nLove\tO\nit\tO\n!\tO\n\nIt\tO\nhas\tO\na\tO\nvery\tO\nhigh\tO\nperformance\tB-aspectTerm\n,\tO\njust\tO\nfor\tO\nwhat\tO\nI\tO\nneeded\tO\nfor\tO\n.\tO\n\nThis\tO\nis\tO\nespecially\tO\ndisheartening\tO\nwhen\tO\nApple\tO\nprides\tO\nitself\tO\nas\tO\nthe\tO\nchoice\tO\nof\tO\ncreative\tO\nprofessionals\tO\n.\tO\n\nApple\tO\nis\tO\naware\tO\nof\tO\nthis\tO\nissue\tO\nand\tO\nthis\tO\nis\tO\neither\tO\nold\tO\nstock\tO\nor\tO\na\tO\ndefective\tO\ndesign\tB-aspectTerm\ninvolving\tO\nthe\tO\nintel\tB-aspectTerm\n4000\tI-aspectTerm\ngraphics\tI-aspectTerm\nchipset\tI-aspectTerm\n.\tO\n\nStop\tO\nliving\tO\nin\tO\nthe\tO\nstone\tO\nage\tO\nand\tO\nbuy\tO\na\tO\nmac\tO\n,\tO\nyou\tO\nwill\tO\nnot\tO\nbe\tO\nsorry\tO\nat\tO\nall\tO\n!\tO\n!\tO\n\nOSX\tB-aspectTerm\nMountain\tI-aspectTerm\nLion\tI-aspectTerm\nsoon\tO\nto\tO\nupgrade\tO\nto\tO\nMavericks\tO\n.\tB-aspectTerm\n\nApple\tO\nhit\tO\na\tO\nhome\tO\nrun\tO\nhere\tO\n.\tO\n\nI\tO\njust\tO\nbought\tO\nthe\tO\nnew\tO\nMacBook\tO\nPro\tO\n,\tO\nthe\tO\n13\tO\n\"\tO\nmodel\tO\n,\tO\nand\tO\nI\tO\nca\tO\nn't\tO\nbelieve\tO\nApple\tO\nkeeps\tO\nmaking\tO\nthe\tO\nsame\tO\nmistake\tO\nwith\tO\nregard\tO\nto\tO\nUSB\tB-aspectTerm\nports\tI-aspectTerm\n.\tO\n\nSo\tO\nglad\tO\nI\tO\nhave\tO\ngone\tO\nthis\tO\nroute\tO\n!\tO\n!\tO\n\nIt\tO\nwakes\tB-aspectTerm\nin\tO\nless\tO\nthan\tO\na\tO\nsecond\tO\nwhen\tO\nI\tO\nopen\tO\nthe\tO\nlid\tB-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nthe\tO\nperfect\tO\nsize\tB-aspectTerm\nand\tO\nspeed\tB-aspectTerm\nfor\tO\nme\tO\n.\tO\n\nI\tO\nam\tO\nso\tO\naddict\tO\nto\tO\nthis\tO\nlaptop\tO\n.\tO\n\nTHE\tO\nCUSTOMER\tB-aspectTerm\nSERVICE\tI-aspectTerm\nIS\tO\nTERRIFIC\tO\n!\tO\n!\tO\n\nTrashed\tO\nit\tO\nwhen\tO\nI\tO\nspilled\tO\na\tO\nlatte\tO\non\tO\nit\tO\nwhile\tO\nwriting\tO\nat\tO\na\tO\ncafe\tO\n.\tO\n\nMy\tO\nlast\tO\nlaptop\tO\nwas\tO\na\tO\n17\tO\n\"\tO\nASUS\tO\ngaming\tO\nmachine\tO\n,\tO\nwhich\tO\nperformed\tB-aspectTerm\nadmirably\tO\n,\tO\nbut\tO\nhaving\tO\nsince\tO\nbuilt\tO\nmy\tO\nown\tO\ndesktop\tO\nand\tO\nreally\tO\nsettling\tO\ninto\tO\nthe\tO\ncollege\tO\nlife\tO\n,\tO\nI\tO\nfound\tO\nmyself\tO\nwanting\tO\nsomething\tO\nsmaller\tO\nand\tO\nless\tO\ncumbersome\tO\n,\tO\nnot\tO\nto\tO\nmention\tO\nthat\tO\nthe\tO\nASUS\tO\nhad\tO\nbeen\tO\nslowly\tO\ndeveloping\tO\nproblems\tO\never\tO\nsince\tO\nI\tO\nbought\tO\nit\tO\nabout\tO\n4\tO\nyears\tO\nago\tO\n.\tO\n\nHowever\tO\n,\tO\nit\tO\ndid\tO\nnot\tO\nhave\tO\nany\tO\nscratches\tO\n,\tO\nZERO\tO\nbattery\tB-aspectTerm\ncycle\tI-aspectTerm\ncount\tI-aspectTerm\n(\tO\npretty\tO\nsurprised\tO\n)\tO\n,\tO\nand\tO\nall\tO\nthe\tO\nhardware\tB-aspectTerm\nseemed\tO\nto\tO\nbe\tO\nworking\tO\nperfectly\tO\n.\tO\n\nAfter\tO\nfumbling\tO\naround\tO\nwith\tO\nthe\tO\nOS\tB-aspectTerm\nI\tO\nstarted\tO\nsearching\tO\nthe\tO\ninternet\tO\nfor\tO\na\tO\nfix\tO\nand\tO\nfound\tO\na\tO\nnumber\tO\nof\tO\nforums\tO\non\tO\nfixing\tO\nthe\tO\nissue\tO\n.\tO\n\nI\tO\ncould\tO\nn't\tO\nbe\tO\nmore\tO\npleased\tO\n.\tO\n\nAnd\tO\nas\tO\nfor\tO\nall\tO\nthe\tO\nfancy\tO\nfinger\tB-aspectTerm\nswipes\tI-aspectTerm\n--\tO\nI\tO\njust\tO\ngave\tO\nup\tO\nand\tO\nattached\tO\na\tO\nmouse\tB-aspectTerm\n.\tO\n\nI\tO\nneeded\tO\na\tO\nlaptop\tO\nwith\tO\nbig\tO\nstorage\tB-aspectTerm\n,\tO\na\tO\nnice\tO\nscreen\tB-aspectTerm\nand\tO\nfast\tO\nso\tO\nI\tO\ncan\tO\nphotoshop\tB-aspectTerm\nwithout\tO\nany\tO\nproblem\tO\n.\tO\n\nI\tO\nlike\tO\ncoming\tO\nback\tO\nto\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nbut\tO\nthis\tO\nlaptop\tO\nis\tO\nlacking\tO\nin\tO\nspeaker\tB-aspectTerm\nquality\tI-aspectTerm\ncompared\tO\nto\tO\nmy\tO\n$\tO\n400\tO\nold\tO\nHP\tO\nlaptop\tO\n.\tO\n\nIt\tO\nis\tO\nmuch\tO\nbetter\tO\nthan\tO\nthe\tO\nAcer\tO\nultrabook\tO\nI\tO\nhad\tO\nbefore\tO\n.\tO\n\nShipped\tB-aspectTerm\nvery\tO\nquickly\tO\nand\tO\nsafely\tO\n.\tO\n\nI\tO\nfinally\tO\nown\tO\na\tO\npiece\tO\nof\tO\ncomputing\tO\nequipment\tO\nthat\tO\nI\tO\ndo\tO\nn't\tO\nwant\tO\nto\tO\ntake\tO\na\tO\nbaseball\tO\nbat\tO\nand\tO\ndestroy\tO\n.\tO\n\nThe\tO\nthunderbolt\tB-aspectTerm\nport\tI-aspectTerm\nis\tO\nawesome\tO\n!\tO\n\nUser\tO\nfriendly\tO\n,\tO\nfast\tO\nand\tO\nhigh\tO\ntech\tO\nIt\tO\nis\tO\namazing\tO\n!\tO\n\nThe\tO\nperformance\tB-aspectTerm\nis\tO\ndefinitely\tO\nsuperior\tO\nto\tO\nany\tO\ncomputer\tO\nI\tO\n've\tO\never\tO\nput\tO\nmy\tO\nhands\tO\non\tO\n.\tO\n\nIt\tO\n's\tO\ngreat\tO\nfor\tO\nstreaming\tB-aspectTerm\nvideo\tI-aspectTerm\nand\tO\nother\tO\nentertainment\tB-aspectTerm\nuses\tI-aspectTerm\n.\tO\n\nApple\tO\ndid\tO\na\tO\ngreat\tO\njob\tO\n.\tO\n\nI\tO\nlike\tO\nthe\tO\ndesign\tB-aspectTerm\nand\tO\nits\tO\nfeatures\tB-aspectTerm\nbut\tO\nthere\tO\nare\tO\nsomethings\tO\nI\tO\nthink\tO\nneeds\tO\nto\tO\nbe\tO\nimproved\tO\n.\tO\n\nThere\tO\nwere\tO\nsmall\tO\nproblems\tO\nwith\tO\nMac\tB-aspectTerm\noffice\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nextremely\tO\nfast\tO\nand\tO\nvery\tO\ncompact\tO\n.\tO\n\nI\tO\nunderstand\tO\nI\tO\nshould\tO\ncall\tO\nApple\tB-aspectTerm\nTech\tI-aspectTerm\nSupport\tI-aspectTerm\nabout\tO\nany\tO\nvariables(which\tO\nis\tO\nmy\tO\npurpose\tO\nof\tO\nwriting\tO\nthis\tO\ncon\tO\n)\tO\nas\tO\nvariables\tO\ncould\tO\nbe\tO\na\tO\nbigger\tO\nfuture\tO\nproblem\tO\n.\tO\n\nI\tO\nordered\tO\nmy\tO\n2012\tO\nmac\tO\nmini\tO\nafter\tO\nbeing\tO\ndisappointed\tO\nwith\tO\nspec\tB-aspectTerm\nof\tO\nthe\tO\nnew\tO\n27\tO\n\"\tO\nImacs\tO\n.\tO\n\nIt\tO\nstill\tO\nworks\tB-aspectTerm\nand\tO\nit\tO\n's\tO\nextremely\tO\nuser\tO\nfriendly\tO\n,\tO\nso\tO\nI\tO\nwould\tO\nrecommend\tO\nit\tO\nfor\tO\nnew\tO\ncomputer\tO\nuser\tO\nand\tO\nalso\tO\nfor\tO\nthose\tO\nwho\tO\nare\tO\njust\tO\nlooking\tO\nfor\tO\na\tO\nmore\tO\nefficient\tO\nway\tO\nto\tO\ndo\tO\nthings\tO\n\nIts\tO\nfast\tO\n,\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nit\tO\nlooks\tB-aspectTerm\ngreat\tO\n.\tO\n\n(\tO\nbut\tO\nOffice\tB-aspectTerm\ncan\tO\nbe\tO\npurchased\tO\n)\tO\nIF\tO\nI\tO\never\tO\nneed\tO\na\tO\nlaptop\tO\nagain\tO\nI\tO\nam\tO\nfor\tO\nsure\tO\npurchasing\tO\nanother\tO\nToshiba\tO\n!\tO\n!\tO\n\nI\tO\nhave\tO\nn't\tO\ntried\tO\nthe\tO\none\tO\nwith\tO\nretina\tB-aspectTerm\ndisplay\tI-aspectTerm\n...\tO\nMaybe\tO\nin\tO\nthe\tO\nfuture\tO\n.\tO\n\nYou\tO\ncan\tO\nread\tO\nall\tO\nabout\tO\nthe\tO\ndetails\tO\nof\tO\nthis\tO\nmarvelous\tO\ncomputer\tO\non\tO\nwikipedia\tO\n.\tO\n\nPerformance\tB-aspectTerm\nis\tO\nmuch\tO\nmuch\tO\nbetter\tO\non\tO\nthe\tO\nPro\tO\n,\tO\nespecially\tO\nif\tO\nyou\tO\ninstall\tO\nan\tO\nSSD\tB-aspectTerm\non\tO\nit\tO\n.\tO\n\nNote\tO\n,\tO\nhowever\tO\n,\tO\nthat\tO\nany\tO\nexisting\tO\nMagSafe\tB-aspectTerm\naccessories\tI-aspectTerm\nyou\tO\nhave\tO\nwill\tO\nnot\tO\nwork\tO\nwith\tO\nthe\tO\nMagSafe\tB-aspectTerm\n2\tI-aspectTerm\nconnection\tI-aspectTerm\n.\tO\n\nIf\tO\nyou\tO\nget\tO\na\tO\nlemon\tO\n(\tO\nI\tO\nhave\tO\ntwo\tO\nthirds\tO\nof\tO\nmy\tO\nMacs\tO\n)\tO\n,\tO\nyou\tO\nhave\tO\nto\tO\nsend\tO\nit\tO\nin\tO\nfor\tO\nrepairs\tO\nseveral\tO\ntimes\tO\nbefore\tO\nthey\tO\nwill\tO\nreplace\tO\nit\tO\n,\tO\neven\tO\nif\tO\nthey\tO\nhave\tO\nnumerous\tO\nproblems\tO\nwith\tO\nthe\tO\nsame\tO\nversion\tO\nof\tO\ntheir\tO\ncomputers\tO\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\ndislike\tO\nis\tO\nthe\tO\ntouchpad\tB-aspectTerm\n,\tO\nalot\tO\nof\tO\nthe\tO\ntimes\tO\nits\tO\nunresponsive\tO\nand\tO\ndoes\tO\nthings\tO\nI\tO\ndo\tO\nnt\tO\nwant\tO\nit\tO\ntoo\tO\n,\tO\nI\tO\nwould\tO\nrecommend\tO\nusing\tO\na\tO\nmouse\tB-aspectTerm\nwith\tO\nit\tO\n.\tO\n\nYeah\tO\n,\tO\nit\tO\n's\tO\nsuper\tO\nexpensive\tO\n.\tO\n\nThe\tO\nMac\tO\nmini\tO\nis\tO\nabout\tO\n8x\tO\nsmaller\tO\nthan\tO\nmy\tO\nold\tO\ncomputer\tO\nwhich\tO\nis\tO\na\tO\nhuge\tO\nbonus\tO\nand\tO\nruns\tB-aspectTerm\nvery\tO\nquiet\tO\n,\tO\nactually\tO\nthe\tO\nfans\tB-aspectTerm\nare\tO\nn't\tO\naudible\tO\nunlike\tO\nmy\tO\nold\tO\npc\tO\n\nMAYBE\tO\nThe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nimprovement\tO\nwere\tO\nnot\tO\nThe\tO\nproduct\tO\nthey\tO\nWant\tO\nto\tO\noffer\tO\n.\tO\n\nIt\tO\ncame\tO\nbefore\tO\nthe\tO\nday\tO\nit\tO\nsupposed\tO\nto\tO\nwhich\tO\nis\tO\ngreat\tO\n.\tO\n\nI\tO\nthought\tO\nthe\tO\ntransition\tO\nwould\tO\nbe\tO\ndifficult\tO\nat\tO\nbest\tO\nand\tO\nwould\tO\ntake\tO\nsome\tO\ntime\tO\nto\tO\nfully\tO\nfamiliarize\tO\nmyself\tO\nwith\tO\nthe\tO\nnew\tO\nMac\tB-aspectTerm\necosystem\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nabsolutely\tO\nwonderful\tO\nand\tO\nworth\tO\nthe\tO\nprice\tB-aspectTerm\n!\tO\n\nIt\tO\n's\tO\na\tO\ngood\tO\nfix\tO\n,\tO\nin\tO\nmy\tO\nopinion\tO\n.\tO\n\nI\tO\nam\tO\nplease\tO\nwith\tO\nthe\tO\nproducts\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\n;\tO\nout\tO\nof\tO\nthe\tO\nbox\tO\nready\tO\n;\tO\nappearance\tB-aspectTerm\nand\tO\nfunctionality\tB-aspectTerm\n.\tO\n\nBuying\tO\na\tO\nMac\tO\nMini\tO\nwould\tO\nallow\tO\nme\tO\nto\tO\nmake\tO\nthe\tO\ntransition\tO\n.\tO\n\nBefore\tO\nI\tO\nbegin\tO\n,\tO\nI\tO\nwill\tO\nsay\tO\nthat\tO\nI\tO\nam\tO\nnot\tO\nlike\tO\na\tO\ngood\tO\npercentage\tO\nof\tO\nthe\tO\npeople\tO\nthat\tO\nwill\tO\nend\tO\nup\tO\nwriting\tO\na\tO\nreview\tO\non\tO\nthis\tO\ncomputer\tO\n-\tO\nI\tO\nam\tO\nnot\tO\nan\tO\nApple\tO\nfanboy\tO\n.\tO\n\nits\tO\nby\tO\nfar\tO\nfaster\tO\nand\tO\nmore\tO\nstable\tO\nthen\tO\nmy\tO\nPC\tO\n.\tO\n\nI\tO\npurchased\tO\na\tO\nMacBook\tO\nPro\tO\nand\tO\nthis\tO\nto\tO\nreplace\tO\na\tO\ncouple\tO\nof\tO\nHP\tO\nunits\tO\nthat\tO\nI\tO\nwas\tO\nusing\tO\n.\tO\n\nyou\tO\nwill\tO\nnot\tO\nregret\tO\nit\tO\n,\tO\npromise\tO\nyou\tO\n!\tO\n\nMoving\tO\nfrom\tO\na\tO\nPC\tO\nto\tO\nMac\tO\nhas\tO\nnever\tO\nbeen\tO\neasier\tO\n,\tO\nand\tO\nI\tO\n'm\tO\nglad\tO\nthat\tO\nI\tO\ndid\tO\nit\tO\n.\tO\n\nPerfect\tO\nfor\tO\nall\tO\nmy\tO\ngraphic\tB-aspectTerm\ndesign\tI-aspectTerm\nclasses\tO\nI\tO\n'm\tO\ntaking\tO\nthis\tO\nyear\tO\nin\tO\ncollege\tO\n:-)\tO\n\nHave\tO\nused\tO\nonly\tO\nMacs\tO\nfor\tO\nyears\tO\n.\tO\n\nBeing\tO\na\tO\ntech\tO\nsavvy\tO\n,\tO\nAPPLE\tO\n-\tO\nproduct\tO\nloving\tO\nperson\tO\n,\tO\nI\tO\n'm\tO\nglad\tO\nI\tO\nfinally\tO\ngot\tO\nthe\tO\nMacBook\tO\nPro\tO\n!\tO\n\nI\tO\nwas\tO\nalways\tO\nagainst\tO\nthem\tO\nbut\tO\nnow\tO\nI\tO\nbuying\tO\none\tO\nI\tO\n'll\tO\nnever\tO\ngo\tO\nback\tO\nto\tO\nPC\tO\n.\tO\n\nI\tO\nwill\tO\nnot\tO\nbe\tO\nusing\tO\nthat\tO\nslot\tB-aspectTerm\nagain\tO\n.\tO\n\nI\tO\nthink\tO\nthat\tO\nwas\tO\na\tO\ngreat\tO\ndecision\tO\nto\tO\nbuy\tO\n\nThe\tO\nOS\tB-aspectTerm\nis\tO\nfast\tO\nand\tO\nfluid\tO\n,\tO\neverything\tO\nis\tO\norganized\tO\nand\tO\nit\tO\n's\tO\njust\tO\nbeautiful\tO\n.\tO\n\nIt\tO\nwill\tO\nmake\tO\nlife\tO\nso\tO\nmuch\tO\neasier\tO\nnext\tO\nsemester\tO\n,\tO\njust\tO\nwish\tO\nI\tO\nhad\tO\nit\tO\nlast\tO\nsemester\tO\n!\tO\n!\tO\n\nI\tO\npaid\tO\nfor\tO\na\tO\nnew\tO\nlaptop\tO\n,\tO\nbut\tO\nwas\tO\nsent\tO\na\tO\nused\tO\none\tO\n.\tO\n\nSearched\tO\nit\tO\non\tO\namazon\tO\nand\tO\non\tO\nbestbuy\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\none\tO\nfor\tO\nmy\tO\n11\tO\nyear\tO\nold\tO\nand\tO\nthe\tO\nMacBook\tO\nAir\tO\nfor\tO\nmy\tO\n9\tO\nyear\tO\nold\tO\n.\tO\n\nI\tO\nbought\tO\nit\tO\nfor\tO\ncollege\tO\nand\tO\nso\tO\nfar\tO\nit\tO\n's\tO\namazing\tO\n!\tO\n\nThey\tO\nare\tO\nsimpler\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nIt\tO\nwas\tO\nat\tO\nmy\tO\ndoor\tO\nin\tO\nless\tO\nthan\tO\n24\tO\nhours\tO\n.\tO\n\nIt\tO\n's\tO\nalso\tO\nvery\tO\npricey\tO\nbut\tO\nyou\tO\njust\tO\nhave\tO\nto\tO\ntell\tO\nyourself\tO\nit\tO\n's\tO\nan\tO\ninvestment\tO\nand\tO\nthat\tO\nit\tO\n's\tO\ngon\tO\nna\tO\nlast\tO\nyou\tO\na\tO\nlong\tO\ntime\tO\n.\tO\n\nIt\tO\nwas\tO\ngetting\tO\nold\tO\nand\tO\nI\tO\nneeded\tO\na\tO\nnew\tO\nschool\tO\ncomputer\tO\n.\tO\n\n!\tO\nso\tO\nnice\tO\n..\tO\nstable\tO\n..\tO\nfast\tO\n..\tO\nnow\tO\ni\tO\ngot\tO\nmy\tO\nSSD\tB-aspectTerm\n!\tO\n\nI\tO\nlove\tO\napple\tO\nbut\tO\nunlike\tO\nothers\tO\nThat\tO\ndoes\tO\nnot\tO\nprevent\tO\nme\tO\nto\tO\nnot\tO\nbe\tO\nhonest\tO\nabout\tO\nhow\tO\ni\tO\nlike\tO\nit\tO\nand\tO\nif\tO\nits\tO\ngood\tO\nor\tO\nnot\tO\n.\tO\n\nSo\tO\n,\tO\nI\tO\n'm\tO\ncooled\tO\non\tO\nMac\tO\nbuys\tO\n.\tO\n\nIt\tO\nis\tO\na\tO\ngreat\tO\ncomputer\tO\nfor\tO\nthat\tO\nand\tO\nI\tO\nhave\tO\nto\tO\nsay\tO\nI\tO\n'm\tO\nhappy\tO\nI\tO\nswitched\tO\n.\tO\n\nAlso\tO\n,\tO\nin\tO\nusing\tO\nthe\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\ncamera\tI-aspectTerm\n,\tO\nmy\tO\nvoice\tB-aspectTerm\nrecording\tI-aspectTerm\nfor\tO\nmy\tO\nvlog\tO\nsounds\tO\nlike\tO\nthe\tO\ninterplanetary\tO\ntransmissions\tO\nin\tO\nthe\tO\n\"\tO\nStar\tO\nWars\tO\n\"\tO\nsaga\tO\n.\tO\n\nOverall\tO\na\tO\nnice\tO\ncomputer\tO\n.\tO\n\nYou\tO\ncan\tO\nimagine\tO\nthat\tO\nan\tO\nexpensive\tO\nitem\tO\nas\tO\na\tO\nlaptop\tO\nwill\tO\nnot\tO\nbe\tO\nleft\tO\non\tO\nyour\tO\nfront\tO\nsteps\tO\n,\tO\nit\tO\nneeds\tO\nsignature\tO\nto\tO\npove\tO\nthat\tO\nyou\tO\nreceived\tO\nit\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nquick\tO\nstart\tB-aspectTerm\nup\tI-aspectTerm\n.\tO\n\nYes\tO\n,\tO\nhe\tO\nis\tO\na\tO\nself\tO\nprofessed\tO\n\"\tO\nMac\tO\nsnob\tO\n.\tO\n\nYou\tO\njust\tO\ncan\tO\nnot\tO\nbeat\tO\nthe\tO\nfunctionality\tB-aspectTerm\nof\tO\nan\tO\nApple\tO\ndevice\tO\n.\tO\n\nYet\tO\nmy\tO\nmac\tO\ncontinues\tO\nto\tO\nfunction\tB-aspectTerm\nproperly\tO\n.\tO\n\nGraphics\tB-aspectTerm\nare\tO\nmuch\tO\nimproved\tO\n.\tO\n\nHere\tO\nare\tO\nthe\tO\nthings\tO\nthat\tO\nmade\tO\nme\tO\nconfident\tO\nwith\tO\nmy\tO\npurchase\tO\n:\tO\nBuild\tB-aspectTerm\nQuality\tI-aspectTerm\n-\tO\nSeriously\tO\n,\tO\nyou\tO\nca\tO\nn't\tO\nbeat\tO\na\tO\nunibody\tB-aspectTerm\nconstruction\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nthe\tO\nmid\tO\n2012\tO\nversion\tO\n.\tO\n\nIt\tO\nprovides\tO\nmuch\tO\nmore\tO\nflexibility\tB-aspectTerm\nfor\tI-aspectTerm\nconnectivity\tI-aspectTerm\n.\tO\n\nI\tO\nwant\tO\nthe\tO\nportability\tB-aspectTerm\nof\tO\na\tO\ntablet\tO\n,\tO\nwithout\tO\nthe\tO\nlimitations\tO\nof\tO\na\tO\ntablet\tO\nand\tO\nthat\tO\n's\tO\nwhere\tO\nthis\tO\nlaptop\tO\ncomes\tO\ninto\tO\nplay\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nmany\tO\n,\tO\nmany\tO\nissues\tO\nwith\tO\nPC\tO\n's\tO\nin\tO\nthe\tO\npast\tO\nand\tO\nI\tO\n'm\tO\nfinally\tO\nglad\tO\nto\tO\nhave\tO\njoined\tO\nthe\tO\nMac\tO\nrevolution\tO\n!\tO\n\nMac\tB-aspectTerm\ntutorials\tI-aspectTerm\ndo\tO\nhelp\tO\n.\tO\n\nWhen\tO\nit\tO\nbroke\tO\nI\tO\nwanted\tO\nanother\tO\nAcer\tO\nand\tO\nchose\tO\nthe\tO\nV5\tO\n.\tO\n\nThe\tO\ntechnical\tB-aspectTerm\nsupport\tI-aspectTerm\nwas\tO\nnot\tO\nhelpful\tO\nas\tO\nwell\tO\n.\tO\n\nI\tO\ngot\tO\nthe\tO\nnew\tO\nadapter\tB-aspectTerm\nand\tO\nthere\tO\nwas\tO\nno\tO\nchange\tO\n.\tO\n\nso\tO\ni\tO\ncalled\tO\ntechnical\tB-aspectTerm\nsupport\tI-aspectTerm\n.\tO\n\nNothing\tO\nabout\tO\nit\tO\nthat\tO\ni\tO\ndo\tO\nn't\tO\nlove\tO\n,\tO\napple\tO\nalways\tO\nmakes\tO\na\tO\ngreat\tO\nproduct\tO\n.\tO\n\nI\tO\nsaved\tO\nabout\tO\n$\tO\n100\tO\nplus\tO\ntax\tO\nordering\tO\non\tO\nAmazon\tO\nand\tO\nsince\tO\nI\tO\nhave\tO\nprime\tO\n,\tO\nit\tO\narrived\tO\novernight\tO\nfor\tO\njust\tO\n$\tO\n3.99\tO\nmore\tO\n.\tO\n\nCame\tO\nwith\tO\niPhoto\tB-aspectTerm\nand\tO\ngarage\tB-aspectTerm\nband\tI-aspectTerm\nalready\tO\nloaded\tO\n.\tO\n\nIt\tO\n's\tO\nall\tO\na\tO\nbit\tO\nmagical\tO\n.\tO\n\nLogic\tB-aspectTerm\nboard\tI-aspectTerm\nutterly\tO\nfried\tO\n,\tO\ncried\tO\n,\tO\nand\tO\nlaid\tO\ndown\tO\nand\tO\ndied\tO\n.\tO\n\nIt\tO\nis\tO\nBLAZING\tO\nfast\tO\n!\tO\n\nThe\tO\nsound\tB-aspectTerm\nwas\tO\ncrappy\tO\neven\tO\nwhen\tO\nyou\tO\nturn\tO\nup\tO\nthe\tO\nvolume\tB-aspectTerm\nstill\tO\nthe\tO\nsame\tO\nresults\tO\n.\tO\n\ni\tO\nve\tO\nnever\tO\nhad\tO\na\tO\nproblem\tO\nwith\tO\nit\tO\n!\tO\n\nI\tO\ncurrently\tO\nown\tO\na\tO\nLenovo\tO\nlaptop\tO\nas\tO\nwell\tO\nas\tO\nmy\tO\nnew\tO\nMacBook\tO\nPro\tO\n,\tO\nand\tO\neach\tO\nhave\tO\ntheir\tO\nown\tO\nstrengths\tO\nand\tO\nweaknesses\tO\n.\tO\n\nOSX\tB-aspectTerm\nLion\tI-aspectTerm\nis\tO\na\tO\ngreat\tO\nperformer\tO\n..\tO\nextremely\tO\nfast\tO\nand\tO\nreliable\tO\n.\tO\n\nBest\tO\ncommuter\tO\nI\tO\nhave\tO\never\tO\nowned\tO\n.\tO\n\nWhat\tO\ncan\tO\nI\tO\nsay\tO\n,\tO\nIt\tO\n's\tO\nan\tO\nApple\tO\n.\tO\n\nHaving\tO\nheard\tO\nfrom\tO\nfriends\tO\nand\tO\nfamily\tO\nabout\tO\nhow\tO\nreliable\tO\na\tO\nMac\tO\nproduct\tO\nis\tO\n,\tO\nI\tO\nnever\tO\nexpected\tO\nto\tO\nhave\tO\nan\tO\napplication\tB-aspectTerm\ncrash\tO\nwithin\tO\nthe\tO\nfirst\tO\nmonth\tO\n,\tO\nbut\tO\nI\tO\ndid\tO\n.\tO\n\nThe\tO\nMacbook\tO\npro\tO\n's\tO\nphysical\tB-aspectTerm\nform\tI-aspectTerm\nis\tO\nwonderful\tO\n.\tO\n\nI\tO\nhave\tO\nan\tO\niPhone\tO\n,\tO\nand\tO\niPad\tO\n,\tO\nso\tO\nit\tO\njust\tO\nmade\tO\nsense\tO\nto\tO\nfinish\tO\noff\tO\nthe\tO\nplatform\tO\nby\tO\nadding\tO\nthe\tO\nMini\tO\n.\tO\n\nNot\tO\nsuper\tO\nlight\tO\nbut\tO\nstill\tO\na\tO\ngood\tO\none\tO\n.\tO\n\nThe\tO\nMini\tO\n's\tO\nbody\tB-aspectTerm\nhas\tO\nn't\tO\nchanged\tO\nsince\tO\nlate\tO\n2010-\tO\nand\tO\nfor\tO\na\tO\ngood\tO\nreason\tO\n.\tO\n\nThe\tO\nunibody\tB-aspectTerm\nconstruction\tI-aspectTerm\nreally\tO\ndoes\tO\nfeel\tO\nlot\tO\nmore\tO\nsolid\tO\nthan\tO\nApple\tO\n's\tO\nprevious\tO\nlaptops\tO\n.\tO\n\ni\tO\nhad\tO\nto\tO\nreturn\tO\nit\tO\nfor\tO\na\tO\nreplacement\tO\n.\tO\n\nIt\tO\nwas\tO\nwonderful\tO\ndeal\tO\nfor\tO\nthe\tO\nwonderful\tO\nproduct\tO\n.\tO\n\nIt\tO\ncompletely\tO\nsupports\tO\nmy\tO\nhome\tO\nbusiness\tO\nand\tO\npersonal\tO\nlife\tO\n.\tO\n\n3D\tB-aspectTerm\nrendering\tI-aspectTerm\nslows\tO\nit\tO\ndown\tO\nconsiderably\tO\n.\tO\n\nGot\tO\nthis\tO\nMac\tO\nMini\tO\nwith\tO\nOS\tB-aspectTerm\nX\tI-aspectTerm\nMountain\tI-aspectTerm\nLion\tI-aspectTerm\nfor\tO\nmy\tO\nwife\tO\n.\tO\n\nI\tO\nam\tO\npleased\tO\nto\tO\nreport\tO\nthat\tO\nit\tO\nis\tO\none\tO\nof\tO\nthe\tO\nbest\tO\npresents\tO\nI\tO\nhave\tO\nreceived\tO\nto\tO\ndate\tO\n.\tO\n\nEvery\tO\nday\tO\nI\tO\nhad\tO\nthis\tO\ncomputer\tO\n,\tO\nsomething\tO\nfailed\tO\non\tO\nit\tO\n.\tO\n\nfast\tO\n,\tO\ngreat\tO\nscreen\tB-aspectTerm\n,\tO\nbeautiful\tO\napps\tB-aspectTerm\nfor\tO\na\tO\nlaptop;priced\tO\nat\tO\n1100\tO\non\tO\nthe\tO\napple\tO\nwebsite;amazon\tO\nhad\tO\nit\tO\nfor\tO\n1098\tO\n+\tO\ntax\tO\n-\tO\nplus\tO\ni\tO\nhad\tO\na\tO\n10\tO\n%\tO\noff\tO\ncoupon\tO\nfrom\tO\namazon\tO\n-\tO\ncost\tO\nme\tO\n998\tO\nplus\tO\ntax-\tO\n1070-\tO\nOTD\tO\n!\tO\n\n12.44\tO\nseconds\tO\nto\tO\nboot\tB-aspectTerm\n.\tO\n\nAll\tO\nthe\tO\nports\tB-aspectTerm\nare\tO\nmuch\tO\nneeded\tO\nsince\tO\nthis\tO\nis\tO\nmy\tO\nmain\tO\ncomputer\tO\n.\tO\n\nThe\tO\nLike\tO\nNew\tO\ncondition\tO\nof\tO\nthe\tO\niMac\tO\nMC309LL\tO\n/\tO\nA\tO\non\tO\nAmazon\tO\nis\tO\nat\tO\n$\tO\n900\tO\n+\tO\nlevel\tO\nonly\tO\n,\tO\nand\tO\nit\tO\nis\tO\na\tO\nQuad\tB-aspectTerm\n-\tI-aspectTerm\nCore\tI-aspectTerm\n2.5\tI-aspectTerm\nGHz\tI-aspectTerm\nCPU\tI-aspectTerm\n(\tO\nsimilar\tO\nto\tO\nthe\tO\n$\tO\n799\tO\nMini\tO\n)\tO\n,\tO\nwith\tO\nRadeon\tB-aspectTerm\nHD\tI-aspectTerm\n6750\tI-aspectTerm\nM\tI-aspectTerm\n512\tI-aspectTerm\nMB\tI-aspectTerm\ngraphic\tI-aspectTerm\ncard\tI-aspectTerm\n(\tO\nthis\tO\nmini\tO\nis\tO\nintegrated\tB-aspectTerm\nIntel\tI-aspectTerm\n4000\tI-aspectTerm\ncard\tI-aspectTerm\n)\tO\n,\tO\nand\tO\nit\tO\neven\tO\ncomes\tO\nwith\tO\nwireless\tB-aspectTerm\nApple\tI-aspectTerm\nKeyboard\tI-aspectTerm\nand\tI-aspectTerm\nMouse\tI-aspectTerm\n,\tO\nall\tO\nput\tO\ntogether\tO\nin\tO\nneat\tO\nand\tO\nnice\tO\npackage\tB-aspectTerm\n.\tO\n\nPut\tO\na\tO\ncover\tB-aspectTerm\non\tO\nit\tO\nand\tO\nis\tO\na\tO\nlittle\tO\nbetter\tO\nbut\tO\nthat\tO\nis\tO\nmy\tO\nonly\tO\ncomplaint\tO\n.\tO\n\nWithin\tO\na\tO\nfew\tO\nhours\tO\nI\tO\nwas\tO\nusing\tO\nthe\tO\ngestures\tB-aspectTerm\nunconsciously\tO\n.\tO\n\nThis\tO\nmac\tO\ndoes\tO\ncome\tO\nwith\tO\nan\tO\nextender\tB-aspectTerm\ncable\tI-aspectTerm\nand\tO\nI\tO\n'm\tO\nusing\tO\nmine\tO\nright\tO\nnow\tO\nhoping\tO\nthe\tO\ncable\tB-aspectTerm\nwill\tO\nstay\tO\nnice\tO\nfor\tO\nthe\tO\nmany\tO\nyears\tO\nI\tO\nplan\tO\non\tO\nusing\tO\nthis\tO\nmac\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nthird\tO\nin\tO\na\tO\nseries\tO\nof\tO\nMacBooks\tO\nstarting\tO\nwith\tO\na\tO\nBlack\tO\nMacBook\tO\n.\tO\n\nThe\tO\n2.9ghz\tB-aspectTerm\ndual\tI-aspectTerm\n-\tI-aspectTerm\ncore\tI-aspectTerm\ni7\tI-aspectTerm\nchip\tI-aspectTerm\nreally\tO\nout\tO\ndoes\tO\nitself\tO\n.\tO\n\nMy\tO\nlife\tO\nhas\tO\nbeen\tO\nenriched\tO\nsince\tO\nI\tO\nhave\tO\nbeen\tO\nusing\tO\nApple\tO\nproducts\tO\n.\tO\n\ni\tO\nFINALLY\tO\nDID\tO\nIT\tO\nAND\tO\nTHIS\tO\nMACHINE\tO\nIS\tO\nTHE\tO\nWAY\tO\nTO\tO\nGO\tO\n!\tO\n\nIt\tO\nis\tO\npretty\tO\nsnappy\tO\nand\tO\nstarts\tB-aspectTerm\nup\tI-aspectTerm\nin\tO\nabout\tO\n30\tO\nseconds\tO\nwhich\tO\nis\tO\ngood\tO\nenough\tO\nfor\tO\nme\tO\n.\tO\n\nThe\tO\nfew\tO\nthings\tO\nthat\tO\nare\tO\nwrong\tO\nwith\tO\nit\tO\nare\tO\nvery\tO\nminor\tO\nthings\tO\n.\tO\n\nSo\tO\nnoise\tB-aspectTerm\nis\tO\nreduced\tO\nat\tO\nleast\tO\n50\tO\n%\tO\nand\tO\nthe\tO\nheat\tB-aspectTerm\nis\tO\nmuch\tO\nbetter\tO\n,\tO\nnow\tO\nit\tO\ndoes\tO\nn't\tO\nfeel\tO\nhot\tO\nbut\tO\nwarm\tO\n.\tO\n\nNot\tO\nsure\tO\non\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\na\tO\nlottery\tO\nat\tO\nthis\tO\npoint\tO\nas\tO\nI\tO\nhave\tO\nread\tO\nthat\tO\nother\tO\nhave\tO\nreceived\tO\nnew\tO\nones\tO\nwith\tO\nthe\tO\nsame\tO\nproblem\tO\n.\tO\n\nMy\tO\none\tO\ncomplaint\tO\nis\tO\nthat\tO\nthere\tO\nwas\tO\nno\tO\ninternal\tB-aspectTerm\nCD\tI-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nThis\tO\nnewer\tO\nnetbook\tO\nhas\tO\nno\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nor\tO\nnetwork\tB-aspectTerm\nlights\tI-aspectTerm\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\ntime\tO\nfor\tO\nme\tO\nto\tO\nuse\tO\na\tO\nMac\tO\nand\tO\nI\tO\n'm\tO\nreally\tO\nhappy\tO\nwith\tO\nthe\tO\nmove\tO\n.\tO\n\nNo\tO\ncomplaints\tO\nfor\tO\nan\tO\nApple\tO\nproduct\tO\n.\tO\n\nThe\tO\nnew\tO\nMacBook\tO\nis\tO\nlightyears\tO\nahead\tO\nof\tO\nmy\tO\nold\tO\nwhite\tO\nplastic\tO\nMacBook\tO\ncirca\tO\n2006\tO\n.\tO\n\nI\tO\nwould\tO\nsay\tO\nthat\tO\n85\tO\n%\tO\nof\tO\nthe\tO\ndesign\tO\nindustry\tO\nis\tO\nMac\tO\nfor\tO\ngood\tO\nreason\tO\n.\tO\n\nI\tO\nwas\tO\nhaving\tO\na\tO\nthough\tO\ntime\tO\ndeciding\tO\nbetween\tO\nthe\tO\n13\tO\n\"\tO\nMacBook\tO\nAir\tO\nor\tO\nthe\tO\nMacBook\tO\nPro\tO\n13\tO\n\"\tO\n(\tO\nBoth\tO\nbaseline\tO\nmodels\tO\n,\tO\npriced\tB-aspectTerm\nat\tO\n1,200\tO\n$\tO\nretail\tO\n)\tO\n\nThe\tO\nlast\tO\nnew\tO\nmac\tO\nI\tO\nbought\tO\nwas\tO\nin\tO\n1998\tO\n.\tO\n\nThere\tO\nare\tO\nreviews\tO\nthat\tO\nspeak\tO\nto\tO\na\tO\nfew\tO\npossible\tO\nglitches\tO\nbut\tO\n,\tO\nI\tO\nhave\tO\nn't\tO\nseen\tO\nthem\tO\nyet\tO\n.\tO\n\nNot\tO\ntoo\tO\nexpense\tO\nand\tO\nhas\tO\nenough\tO\nstorage\tB-aspectTerm\nfor\tO\nmost\tO\nusers\tO\nand\tO\nmany\tO\nports\tB-aspectTerm\n.\tO\n\nI\tO\nam\tO\nvery\tO\nsatisfied\tO\nwith\tO\nthe\tO\nmini\tO\n.\tO\n\nThe\tO\naudio\tB-aspectTerm\nvolume\tI-aspectTerm\nis\tO\nquite\tO\nlow\tO\nand\tO\nvirtually\tO\nunusable\tO\nin\tO\na\tO\nroom\tO\nwith\tO\nany\tO\nbackground\tO\nactivity\tO\n.\tO\n\nI\tO\nam\tO\ngoing\tO\nto\tO\ncollege\tO\nnext\tO\nyear\tO\nand\tO\nI\tO\nneeded\tO\na\tO\ncheaper\tO\n,\tO\nquality\tO\ncomputer\tO\nfor\tO\nthe\tO\ngoals\tO\nI\tO\nam\tO\ntrying\tO\nto\tO\npursue\tO\n.\tO\n\nIn\tO\nthe\tO\nshort\tO\ntime\tO\nof\tO\none\tO\nmonth\tO\nsince\tO\nthe\tO\n2012\tO\nMac\tO\nMini\tO\nwas\tO\nreleased\tO\nthere\tO\nare\tO\nwell\tO\nover\tO\n1000\tO\nposts\tO\nregarding\tO\nthis\tO\nissue\tO\nand\tO\nthe\tO\nnumbers\tO\nkeep\tO\nrising\tO\n.\tO\n\nIt\tO\nis\tO\nlightweight\tO\nand\tO\nthe\tO\nperfect\tO\nsize\tB-aspectTerm\nto\tO\ncarry\tO\nto\tO\nclass\tO\n.\tO\n\nIf\tO\nyou\tO\nhave\tO\nto\tO\nask\tO\nyou\tO\ndo\tO\nn't\tO\nown\tO\na\tO\nMac\tO\nand\tO\nyour\tO\njust\tO\nnot\tO\nin\tO\nthe\tO\nknow\tO\n.\tO\n\nAll\tO\nmy\tO\ndevises\tO\n“\tO\ntalk\tO\n”\tO\nto\tO\neach\tO\nother\tO\n.\tO\n\nWhy\tO\nnot\tO\n5\tO\nstars\tO\n?\tO\n\nVery\tO\nVery\tO\nHighly\tO\nRecommended\tO\n.\tO\n\n?\tO\nI\tO\nam\tO\nonly\tO\ninterested\tO\nin\tO\nthe\tO\n15.4\tO\nMcBook\tO\nPro\tO\nModel\tO\n#\tO\nMD103LL\tO\n/\tO\nA\tO\n\nI\tO\ndo\tO\nn't\tO\nknow\tO\nwhy\tO\nI\tO\ndid\tO\nn't\tO\nmake\tO\nthe\tO\nswitch\tO\nsooner\tO\n...\tO\no\tO\nya\tO\nbecause\tO\nit\tO\n's\tO\nexpensive\tO\n.\tO\n\nI\tO\nwas\tO\ngiven\tO\na\tO\ndemonstration\tO\nof\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\n.\tO\n\nThe\tO\nMacbook\tO\nPro\tO\nis\tO\nthe\tO\npremier\tO\nchoice\tO\nfor\tO\ncollege\tO\nstudents\tO\n.\tO\n\nTheir\tO\nproducts\tO\n,\tO\nincluding\tO\nthe\tO\nMBP\tO\n,\tO\nare\tO\nbeautiful\tO\n,\tO\nsleek\tO\nand\tO\nclever\tO\n.\tO\n\nThe\tO\nMBP\tO\nis\tO\nbeautiful\tO\nhas\tO\nmany\tO\nwonderful\tO\ncapabilities\tB-aspectTerm\n.\tO\n\nI\tO\nthought\tO\nthat\tO\nit\tO\nwill\tO\nbe\tO\nfine\tO\n,\tO\nif\tO\ni\tO\ndo\tO\nsome\tO\nsettings\tB-aspectTerm\n.\tO\n\nRuns\tB-aspectTerm\nvery\tO\nsmoothly\tO\n.\tO\n\nPerfect\tO\n--\tO\nthanks\tO\nso\tO\n.\tO\n\nAlso\tO\n,\tO\nit\tO\nhardly\tO\never\tO\ncrashes\tO\n.\tO\n\nI\tO\nwas\tO\nso\tO\nexcited\tO\nto\tO\nget\tO\nthis\tO\nin\tO\nthe\tO\nmail\tO\ni\tO\nnearly\tO\ngave\tO\nmyself\tO\na\tO\nheart\tO\nattack\tO\n.\tO\n\nBoot\tB-aspectTerm\n-\tI-aspectTerm\nup\tI-aspectTerm\nslowed\tO\nsignificantly\tO\nafter\tO\nall\tO\nWindows\tB-aspectTerm\nupdates\tI-aspectTerm\nwere\tO\ninstalled\tO\n.\tO\n\nMore\tO\nlikely\tO\nit\tO\nwill\tO\nrequire\tO\nreplacing\tO\nthe\tO\nlogic\tB-aspectTerm\nboard\tI-aspectTerm\nonce\tO\nthey\tO\nadmit\tO\nthey\tO\nhave\tO\na\tO\nproblem\tO\nand\tO\ncome\tO\nup\tO\nwith\tO\na\tO\nsolution\tO\n.\tO\n\nWhen\tO\ni\tO\nfinally\tO\nheld\tO\nit\tO\nin\tO\nmy\tO\nhands\tO\ni\tO\nkissed\tO\nit\tO\n,\tO\nyes\tO\ni\tO\ndid\tO\n.\tO\n\nIt\tO\nwas\tO\nimportant\tO\nthat\tO\nit\tO\nwas\tO\npowerful\tO\nenough\tO\nto\tO\ndo\tO\nall\tO\nof\tO\nthe\tO\ntasks\tO\nhe\tO\nneeded\tO\non\tO\nthe\tO\ninternet\tB-aspectTerm\n,\tO\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\n,\tO\ngraphic\tB-aspectTerm\ndesign\tI-aspectTerm\nand\tO\ngaming\tB-aspectTerm\n.\tO\n\nThis\tO\ncomputer\tO\nis\tO\nnot\tO\ncheap\tO\nand\tO\nrepresent\tO\nan\tO\nachievement\tO\nfor\tO\nme\tO\n.\tO\n\nI\tO\nlike\tO\nthe\tO\nMini\tO\nMac\tO\nit\tO\nwas\tO\neasy\tO\nto\tO\nsetup\tB-aspectTerm\nand\tO\ninstall\tB-aspectTerm\n,\tO\nbut\tO\nI\tO\nam\tO\nlearning\tO\nas\tO\nI\tO\ngo\tO\nand\tO\ncould\tO\nuse\tO\na\tO\ntutorial\tB-aspectTerm\nto\tO\nlearn\tO\nhow\tO\nto\tO\nuse\tO\nsome\tO\nof\tO\nthe\tO\nfeatures\tB-aspectTerm\nI\tO\nwas\tO\nuse\tO\nto\tO\non\tO\nthe\tO\nPC\tO\nespecially\tO\nthe\tO\nright\tB-aspectTerm\nmouse\tI-aspectTerm\nclick\tI-aspectTerm\nmenu\tI-aspectTerm\n.\tO\n\nGET\tO\nTHIS\tO\nMACHINE\tO\n\nIt\tO\n's\tO\nshiny\tO\nand\tO\nit\tO\n's\tO\npretty\tO\n.\tO\n\nRuns\tB-aspectTerm\nreal\tO\nquick\tO\n.\tO\n\nAll\tO\nthe\tO\nabove\tO\naside\tO\nthis\tO\nmachine\tO\nROCKS\tO\n!\tO\n\nBuy\tO\nthe\tO\nseparate\tO\nRAM\tB-aspectTerm\nmemory\tI-aspectTerm\nand\tO\nyou\tO\nwill\tO\nhave\tO\na\tO\nrocket\tO\n!\tO\n\nSince\tO\nthe\tO\nmachine\tO\n's\tO\nslim\tO\nprofile\tB-aspectTerm\nis\tO\ncritical\tO\nto\tO\nme\tO\n,\tO\nthat\tO\nwas\tO\na\tO\nproblem\tO\n.\tO\n\nBottom\tO\nline\tO\n,\tO\nif\tO\nyou\tO\ncan\tO\nafford\tO\nit\tO\n,\tO\nget\tO\na\tO\nMac\tO\n!\tO\n\nI\tO\nfinally\tO\nmade\tO\nthe\tO\nleap\tO\nafter\tO\nmy\tO\nGateway\tO\ncrapped\tO\nout\tO\non\tO\nme\tO\n.\tO\n\nWiFi\tB-aspectTerm\ncapability\tI-aspectTerm\n,\tO\ndisk\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nmultiple\tO\nUSB\tB-aspectTerm\nports\tI-aspectTerm\nto\tO\nconnect\tO\nscale\tO\nand\tO\nprinters\tO\nwas\tO\nall\tO\nthat\tO\nwas\tO\nrequired\tO\n.\tO\n\nThe\tO\nSD\tB-aspectTerm\ncard\tI-aspectTerm\nreader\tI-aspectTerm\nis\tO\nslightly\tO\nrecessed\tO\nand\tO\nupside\tO\ndown\tO\n(\tO\nthe\tO\nnail\tB-aspectTerm\nslot\tI-aspectTerm\non\tI-aspectTerm\nthe\tI-aspectTerm\ncard\tI-aspectTerm\ncan\tO\nnot\tO\nbe\tO\naccessed\tO\n)\tO\n,\tO\nif\tO\nthis\tO\nwas\tO\na\tO\nself\tO\nejecting\tO\nslot\tB-aspectTerm\nthis\tO\nwould\tO\nnot\tO\nbe\tO\nan\tO\nissue\tO\n,\tO\nbut\tO\nits\tO\nnot\tO\n.\tO\n\nSoft\tO\ntouch\tB-aspectTerm\n,\tO\nanodized\tB-aspectTerm\naluminum\tI-aspectTerm\nwith\tO\nlaser\tO\ncut\tO\nprecision\tO\nand\tO\nno\tO\nflaws\tO\n.\tO\n\nSimple\tO\ndetails\tO\n,\tO\ncrafted\tO\naluminium\tB-aspectTerm\nand\tO\nreal\tO\nglass\tB-aspectTerm\nmake\tO\nthis\tO\nlaptop\tO\nblow\tO\naway\tO\nthe\tO\nother\tO\nplastic\tO\nridden\tO\n,\tO\nbulky\tO\nsticker\tO\nfilled\tO\nlaptops\tO\n.\tO\n\nFirst\tO\nof\tO\nall\tO\nyes\tO\nthis\tO\nis\tO\na\tO\nmac\tO\nand\tO\nit\tO\nhas\tO\nthat\tO\nnice\tO\nbrushed\tO\naluminum\tB-aspectTerm\n.\tO\n\nWho\tO\nmakes\tO\na\tO\nlaptop\tO\nthat\tO\nca\tO\nn't\tO\nrest\tO\non\tO\nyour\tO\nlap\tO\n?\tO\n\nAfter\tO\nall\tO\nwas\tO\nsaid\tO\nand\tO\ndone\tO\n,\tO\nI\tO\nessentially\tO\nused\tO\nthat\tO\n$\tO\n450\tO\nsavings\tO\nto\tO\nbuy\tO\n16\tB-aspectTerm\nGB\tI-aspectTerm\nof\tI-aspectTerm\nRAM\tI-aspectTerm\n,\tO\nTWO\tO\nSeagate\tB-aspectTerm\nMomentus\tI-aspectTerm\nXT\tI-aspectTerm\nhybrid\tI-aspectTerm\ndrives\tI-aspectTerm\nand\tO\nan\tO\nOWC\tB-aspectTerm\nupgrade\tI-aspectTerm\nkit\tI-aspectTerm\nto\tO\ninstall\tO\nthe\tO\nsecond\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nThe\tO\nDell\tO\nInspiron\tO\nis\tO\nfast\tO\nand\tO\nhas\tO\na\tO\nnumber\tB-aspectTerm\npad\tI-aspectTerm\non\tI-aspectTerm\nthe\tI-aspectTerm\nkeyboard\tI-aspectTerm\n,\tO\nwhich\tO\nI\tO\nmiss\tO\non\tO\nmy\tO\nApple\tO\nlaptops\tO\n.\tO\n\nwow\tO\nthe\tO\nnew\tO\nmacbook\tO\npro\tO\nhanged\tO\nas\tO\ni\tO\ntried\tO\nto\tO\ntype\tO\nthis\tO\nreview\tO\n.\tO\n\nThe\tO\nMacBook\tO\nPro\tO\nis\tO\na\tO\ngreat\tO\nproduct\tO\nwhich\tO\ncan\tO\nmeet\tO\nthe\tO\nneeds\tO\nof\tO\nthe\tO\naverage\tO\nconsumer\tO\n.\tO\n\nI\tO\nwas\tO\nconcerned\tO\nthat\tO\nthe\tO\ndowngrade\tO\nto\tO\nthe\tO\nregular\tB-aspectTerm\nhard\tI-aspectTerm\ndrive\tI-aspectTerm\nwould\tO\nmake\tO\nit\tO\nunacceptably\tO\nslow\tO\nbut\tO\nI\tO\nneed\tO\nnot\tO\nhave\tO\nworried\tO\n-\tO\nthis\tO\nmachine\tO\nis\tO\nthe\tO\nfastest\tO\nI\tO\nhave\tO\never\tO\nowned\tO\n...\tO\n\nThis\tO\none\tO\nstill\tO\nhas\tO\nthe\tO\nCD\tB-aspectTerm\nslot\tI-aspectTerm\n.\tO\n\nNo\tO\nHDMI\tB-aspectTerm\nport\tI-aspectTerm\n.\tO\n\nI\tO\nhad\tO\nto\tO\ninstall\tB-aspectTerm\nMountain\tI-aspectTerm\nLion\tI-aspectTerm\nand\tO\nit\tO\ntook\tO\na\tO\ngood\tO\ntwo\tO\nhours\tO\n.\tO\n\nCustomization\tB-aspectTerm\non\tO\nmac\tO\nis\tO\nimpossible\tO\n.\tO\n\nI\tO\nhope\tO\nthis\tO\nreview\tO\nhelps\tO\n.\tO\n\nHowever\tO\n,\tO\nyou\tO\nhave\tO\nto\tO\nadjust\tO\nyourself\tO\nto\tO\nwhat\tO\nit\tO\nwill\tO\ndo\tO\n,\tO\nnot\tO\nwhat\tO\nyou\tO\nwant\tO\nit\tO\nto\tO\ndo\tO\n.\tO\n\nI\tO\nam\tO\nreplacing\tO\nthe\tO\nHD\tB-aspectTerm\nwith\tO\na\tO\nMicron\tB-aspectTerm\nSSD\tI-aspectTerm\nsoon\tO\n.\tO\n\nPlus\tO\ntwo\tB-aspectTerm\nfinger\tI-aspectTerm\nclicking\tI-aspectTerm\nas\tO\na\tO\nreplacement\tO\nfor\tO\nthe\tO\nright\tB-aspectTerm\nclick\tI-aspectTerm\nbutton\tI-aspectTerm\nis\tO\nsurprisingly\tO\nintuitive\tO\n.\tO\n\nFar\tO\nsuperior\tO\nto\tO\nmy\tO\nMacBook\tO\n.\tO\n\nThe\tO\nSuperDrive\tB-aspectTerm\nis\tO\nquiet\tO\n.\tO\n\nIt\tO\nwas\tO\nquite\tO\neasy\tO\n.\tO\n\nThe\tO\npower\tB-aspectTerm\nplug\tI-aspectTerm\nhas\tO\nto\tO\nbe\tO\nconnected\tO\nto\tO\nthe\tO\npower\tB-aspectTerm\nadaptor\tI-aspectTerm\nto\tO\ncharge\tO\nthe\tO\nbattery\tB-aspectTerm\nbut\tO\nwo\tO\nn't\tO\nstay\tO\nconnected\tO\n.\tO\n\nI\tO\ndecided\tO\nto\tO\nbuy\tO\na\tO\nfew\tO\nnotebooks\tO\nfor\tO\nmy\tO\nnephews\tO\nfor\tO\nXmas\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nwas\tO\ncompletely\tO\ndead\tO\n,\tO\nin\tO\nfact\tO\nit\tO\nhad\tO\ngrown\tO\nabout\tO\na\tO\nquarter\tO\ninch\tO\nthick\tO\nlump\tO\non\tO\nthe\tO\nunderside\tO\n.\tO\n\nThis\tO\nis\tO\nno\tO\nexception\tO\n.\tO\n\nif\tO\nyo\tO\nlike\tO\npracticality\tB-aspectTerm\nthis\tO\nis\tO\nthe\tO\nlaptop\tO\nfor\tO\nyou\tO\n.\tO\n\nThe\tO\nOS\tB-aspectTerm\nis\tO\ngreat\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\na\tO\nblack\tO\nmacbook\tO\nsince\tO\n2007\tO\n.\tO\n\nI\tO\ntried\tO\nseveral\tO\nmonitors\tB-aspectTerm\nand\tO\nseveral\tO\nHDMI\tB-aspectTerm\ncables\tI-aspectTerm\nand\tO\nthis\tO\nwas\tO\nthe\tO\ncase\tO\neach\tO\ntime\tO\n.\tO\n\nCONS\tO\n:\tO\nPrice\tB-aspectTerm\nis\tO\na\tO\nbit\tO\nridiculous\tO\n,\tO\nkinda\tO\nheavy\tO\n.\tO\n\nIf\tO\nthat\tO\nis\tO\nthe\tO\ncase\tO\n,\tO\nthen\tO\nI\tO\nam\tO\ncompletely\tO\nhappy\tO\n\n10/10\tO\nfive\tO\nstars\tO\nwould\tO\nrecommend\tO\n.\tO\n\nThe\tO\ntroubleshooting\tO\nsaid\tO\nit\tO\nwas\tO\nthe\tO\nAC\tB-aspectTerm\nadaptor\tI-aspectTerm\nso\tO\nwe\tO\nordered\tO\na\tO\nnew\tO\none\tO\n.\tO\n\nI\tO\nfell\tO\nin\tO\nlove\tO\nwith\tO\nmy\tO\nmachine\tO\n,\tO\nand\tO\nit\tO\nwas\tO\npampered\tO\n.\tO\n\nFan\tB-aspectTerm\nonly\tO\ncomes\tO\non\tO\nwhen\tO\nyou\tO\nare\tO\nplaying\tB-aspectTerm\na\tI-aspectTerm\ngame\tI-aspectTerm\n.\tO\n\nWhich\tO\nit\tO\ndid\tO\nnot\tO\nhave\tO\n,\tO\nonly\tO\n3\tO\nUSB\tB-aspectTerm\n2\tI-aspectTerm\nports\tI-aspectTerm\n.\tO\n\nNo\tO\nstartup\tB-aspectTerm\ndisk\tI-aspectTerm\nwas\tO\nnot\tO\nincluded\tO\nbut\tO\nthat\tO\nmay\tO\nbe\tO\nmy\tO\nfault\tO\n.\tO\n\nThere\tO\nis\tO\nno\tO\n\"\tB-aspectTerm\ntools\tI-aspectTerm\n\"\tI-aspectTerm\nmenu\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nvery\tO\nfast\tO\nand\tO\nhas\tO\neverything\tO\nthat\tO\nI\tO\nneed\tO\nexcept\tO\nfor\tO\na\tO\nword\tB-aspectTerm\nprogram\tI-aspectTerm\n.\tO\n\nNeeds\tO\na\tO\nCD\tB-aspectTerm\n/\tI-aspectTerm\nDVD\tI-aspectTerm\ndrive\tI-aspectTerm\nand\tO\na\tO\nbigger\tO\npower\tB-aspectTerm\nswitch\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nthe\tO\nbest\tO\nlaptop\tO\never\tO\n!\tO\n!\tO\n!\tO\n\nMy\tO\nlaptop\tO\nwith\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\ncrashed\tO\nand\tO\nI\tO\ndid\tO\nnot\tO\nwant\tO\nWindows\tB-aspectTerm\n8\tI-aspectTerm\n.\tO\n\nWas\tO\nskeptical\tO\nabout\tO\nbuying\tO\nan\tO\nelectronic\tO\nitem\tO\nonline\tO\nbut\tO\nit\tO\nturned\tO\nout\tO\nto\tO\nbe\tO\na\tO\npositive\tO\nexperience\tO\n.\tO\n\nNot\tO\na\tO\nscratch\tO\nor\tO\nmark\tO\non\tO\nit\tO\n.\tO\n\nEasy\tO\nto\tO\ninstall\tB-aspectTerm\nalso\tO\nsmall\tO\nto\tO\nleave\tO\nanywhere\tO\nat\tO\nyour\tO\nbedroom\tO\nalso\tO\nvery\tO\neasy\tO\nto\tO\nconfigure\tB-aspectTerm\nfor\tI-aspectTerm\nADSl\tI-aspectTerm\ncable\tI-aspectTerm\nor\tI-aspectTerm\nwifi\tI-aspectTerm\n.\tO\n\nWords\tO\ncan\tO\nnot\tO\nexpress\tO\nhow\tO\nmuch\tO\nI\tO\nlove\tO\nmy\tO\nnew\tO\nMac\tO\n.\tO\n\nThe\tO\nspeakers\tB-aspectTerm\ncould\tO\nhave\tO\nbeen\tO\nbetter\tO\nbut\tO\nit\tO\nwas\tO\nn't\tO\na\tO\ndeal\tO\nbreaker\tO\n...\tO\nthis\tO\nis\tO\na\tO\ngreat\tO\nlittle\tO\nlaptop\tO\n...\tO\nlove\tO\nit\tO\n!\tO\n\nThe\tO\nitem\tO\nreceived\tO\nwas\tO\nexactly\tO\nas\tO\nidentified\tO\n.\tO\n\nIts\tO\neverything\tO\nmac\tO\noffers\tO\n.\tO\n\nNice\tO\npacking\tB-aspectTerm\n.\tO\n\nBesides\tO\nbeing\tO\nelegant\tO\n,\tO\nthe\tO\nMacBooks\tO\nare\tO\ndurable\tO\n.\tO\n\nI\tO\nswitched\tO\nto\tO\nthis\tO\nbecause\tO\nI\tO\nwanted\tO\nsomething\tO\ndifferent\tO\n,\tO\neven\tO\nthough\tO\nI\tO\nmiss\tO\nwindows\tB-aspectTerm\n.\tO\n\nYes\tO\n,\tO\nthe\tO\nMBP\tO\nis\tO\nmore\tO\nexpensive\tO\nthan\tO\ncompeting\tO\nPC\tO\nlaptops\tO\n.\tO\n\nApple\tO\nno\tO\nlonger\tO\nincludes\tO\niDVD\tB-aspectTerm\nwith\tO\nthe\tO\ncomputer\tO\nand\tO\nfurthermore\tO\n,\tO\nApple\tO\ndoes\tO\nn't\tO\neven\tO\noffer\tO\nit\tO\nanymore\tO\n!\tO\n\nI\tO\nalso\tO\nwanted\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\n,\tO\nwhich\tO\nthis\tO\none\tO\nhas\tO\n.\tO\n\nAt\tO\nfirst\tO\n,\tO\nI\tO\nfeel\tO\na\tO\nlittle\tO\nbit\tO\nuncomfortable\tO\nin\tO\nusing\tO\nthe\tO\nMac\tB-aspectTerm\nsystem\tI-aspectTerm\n.\tO\n\nI\tO\nam\tO\nused\tO\nto\tO\ncomputers\tO\nwith\tO\nwindows\tB-aspectTerm\nso\tO\nI\tO\nam\tO\nhaving\tO\na\tO\nlittle\tO\ndifficulty\tO\nfinding\tO\nmy\tO\nway\tO\naround\tO\n.\tO\n\nThey\tO\nreplaced\tO\nit\tO\nand\tO\nso\tO\nfar\tO\nso\tO\ngood\tO\n.\tO\n\nIt\tO\njust\tO\nworks\tB-aspectTerm\nout\tO\nof\tO\nthe\tO\nbox\tO\nand\tO\nyou\tO\nhave\tO\na\tO\nlot\tO\nof\tO\ncool\tO\nsoftware\tB-aspectTerm\nincluded\tO\nwith\tO\nthe\tO\nOS\tB-aspectTerm\n.\tO\n\nGood\tO\nin\tO\nevery\tO\naspect\tO\n.\tO\n\nits\tO\nas\tO\nadvertised\tO\non\tO\nhere\tO\n.....\tO\nit\tO\nworks\tB-aspectTerm\ngreat\tO\nand\tO\nis\tO\nnot\tO\na\tO\nwaste\tO\nof\tO\nmoney\tO\n!\tO\n\nReplaced\tO\nthis\tO\none\tO\nwith\tO\nmy\tO\nmac\tO\nthat\tO\nwas\tO\nstolen\tO\n,\tO\nits\tO\na\tO\ngreat\tO\ncomputer\tO\n.\tO\n\nJust\tO\nbe\tO\ncareful\tO\n;\tO\nyou\tO\nalways\tO\nhave\tO\nto\tO\ngive\tO\nup\tO\nsome\tO\ngood\tO\nstuff\tO\nfor\tO\nothers\tO\n.\tO\n\nRuns\tB-aspectTerm\nlike\tO\na\tO\nchamp\tO\n.....\tO\n\nReally\tO\ngreat\tO\n...\tO\nWell\tO\nlet\tO\nme\tO\nstart\tO\nat\tO\nthe\tO\nbeginning\tO\n.\tO\n\nPremium\tO\nprice\tB-aspectTerm\nfor\tO\nthe\tO\nOS\tB-aspectTerm\nmore\tO\nthan\tO\nanything\tO\nelse\tO\n.\tO\n\nThis\tO\nwas\tO\na\tO\ngift\tO\nfor\tO\nmy\tO\ngrand\tO\nson\tO\n.\tO\n\nI\tO\nwas\tO\na\tO\nlittle\tO\nconcerned\tO\nabout\tO\nthe\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\nbased\tO\non\tO\nreviews\tO\n,\tO\nbut\tO\nI\tO\n've\tO\nfound\tO\nit\tO\nfine\tO\nto\tO\nwork\tO\nwith\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nMac\tO\nbook\tO\npro\tO\nalong\tO\nwith\tO\na\tO\nnew\tO\n27\tO\n\"\tO\niMac\tO\nand\tO\nwhile\tO\nthey\tO\nare\tO\nstill\tO\nlight\tO\nyears\tO\nmore\tO\nreliable\tO\nthan\tO\na\tO\nPC\tO\nI\tO\nhave\tO\nnoticed\tO\na\tO\ndecline\tO\nin\tO\nthe\tO\nreliability\tB-aspectTerm\nof\tO\nmy\tO\nMac\tO\ncomputers\tO\n.\tO\n\nThe\tO\nsound\tB-aspectTerm\nas\tO\nmentioned\tO\nearlier\tO\nis\tO\nn't\tO\nthe\tO\nbest\tO\n,\tO\nbut\tO\nit\tO\ncan\tO\nbe\tO\nsolved\tO\nwith\tO\nheadphones\tB-aspectTerm\n.\tO\n\nThe\tO\ntrack\tB-aspectTerm\npad\tI-aspectTerm\nis\tO\na\tO\nbit\tO\nsquirrely\tO\nat\tO\ntimes-\tO\nsometimes\tO\ntoo\tO\nsensitive\tO\n,\tO\nand\tO\nsometimes\tO\na\tO\nbit\tO\nunresponsive\tO\n,\tO\nbut\tO\nit\tO\n's\tO\nusable\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nexperience\tO\nwas\tO\ngreat\tO\nsince\tO\nthe\tO\nOS\tB-aspectTerm\ndoes\tO\nnot\tO\nbecome\tO\nunstable\tO\nand\tO\nthe\tO\napplication\tB-aspectTerm\nwill\tO\nsimply\tO\nshutdown\tO\nand\tO\nreopen\tO\n.\tO\n\nThen\tO\nonly\tO\nFOUR\tO\nmonths\tO\nlater\tO\n,\tO\nmy\tO\ngreat\tO\nMacBook\tO\npro\tO\nFAILED\tO\n.\tO\n\nIf\tO\nyou\tO\nask\tO\nme\tO\n,\tO\nfor\tO\nthis\tO\nprice\tB-aspectTerm\nit\tO\nshould\tO\nbe\tO\nincluded\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nis\tO\nnot\tO\nas\tO\nshown\tO\nin\tO\nthe\tO\nproduct\tO\nphotos\tO\n.\tO\n\nEven\tO\nthough\tO\nI\tO\ncould\tO\nhave\tO\ngotten\tO\na\tO\npc\tO\ntwice\tO\nthe\tO\nspeed\tB-aspectTerm\nfor\tO\nthe\tO\nsame\tO\nprice\tB-aspectTerm\nI\tO\nstill\tO\nthink\tO\nthere\tO\n's\tO\nnothing\tO\nlike\tO\na\tO\nMac\tO\n.\tO\n\nSeems\tO\na\tO\nmuch\tO\nmore\tO\neconomical\tO\nway\tO\nto\tO\nget\tO\ninto\tO\nApple\tO\nthan\tO\ntheir\tO\nother\tO\ncomputers\tO\n.\tO\n\nShipping\tB-aspectTerm\nwas\tO\nquick\tO\nand\tO\nproduct\tO\ndescribed\tO\nwas\tO\nthe\tO\nproduct\tO\nsent\tO\nand\tO\nso\tO\nmuch\tO\nmore\tO\n...\tO\n\nI\tO\n'm\tO\nso\tO\ndisgusted\tO\nthat\tO\nI\tO\nwasted\tO\nmy\tO\nmoney\tO\non\tO\nthis\tO\nproduct\tO\n.\tO\n\nAll\tO\nyou\tO\nget\tO\nis\tO\na\tO\nbox\tO\nand\tO\na\tO\ncomputer\tO\n.\tO\n\nthe\tO\nretina\tB-aspectTerm\ndisplay\tI-aspectTerm\ndisplay\tI-aspectTerm\nmake\tO\npictures\tO\ni\tO\ntook\tO\nyears\tO\nago\tO\njaw\tO\ndropping\tO\n.\tO\n\nIts\tO\nonly\tO\ncrashed\tO\non\tO\nme\tO\none\tO\ntime\tO\nin\tO\nthe\tO\n3\tO\nmonths\tO\ni\tO\n've\tO\nhad\tO\nit\tO\n.\tO\n\nThe\tO\nMac\tO\nMini\tO\nis\tO\nprobably\tO\nthe\tO\nsimplest\tO\nexample\tO\nof\tO\ncompact\tB-aspectTerm\ncomputing\tI-aspectTerm\nout\tO\nthere\tO\n.\tO\n\nInstead\tO\n,\tO\nI\tO\n'll\tO\nfocus\tO\nmore\tO\non\tO\nthe\tO\nactual\tO\nperformance\tB-aspectTerm\nand\tI-aspectTerm\nfeature\tI-aspectTerm\nset\tI-aspectTerm\nof\tI-aspectTerm\nthe\tI-aspectTerm\nhardware\tI-aspectTerm\nitself\tO\nso\tO\nyou\tO\ncan\tO\nmake\tO\nan\tO\neducated\tO\ndecision\tO\non\tO\nwhich\tO\nMac\tO\nto\tO\nbuy\tO\n.\tO\n\nMy\tO\nbag\tO\njust\tO\ngot\tO\na\tO\nlittle\tO\nlighter\tO\n.\tO\n\nI\tO\n'm\tO\nNot\tO\nexagerating\tO\nwhen\tO\nI\tO\nsay\tO\nthis\tO\ncomputer\tO\nis\tO\nperfect\tO\n..\tO\ni\tO\nIt\tO\nis\tO\n!\tO\n!\tO\n\nThis\tO\nmachine\tO\nis\tO\nflawless\tO\n,\tO\nfast\tO\n,\tO\nand\tO\nclassy\tO\n.\tO\n\nOther\tO\nports\tB-aspectTerm\ninclude\tO\nFireWire\tB-aspectTerm\n800\tI-aspectTerm\n,\tO\nGigabit\tB-aspectTerm\nEthernet\tI-aspectTerm\n,\tO\nMagSafe\tB-aspectTerm\nport\tI-aspectTerm\n,\tO\nMicrophone\tB-aspectTerm\njack\tI-aspectTerm\n.\tO\n\nI\tO\nstayed\tO\nup\tO\nhalf\tO\nthe\tO\nnight\tO\nenjoying\tO\nmy\tO\nnew\tO\nMacBook\tO\nPro\tO\n.\tO\n\nThis\tO\nlaptop\tO\nis\tO\na\tO\n100\tO\ntimes\tO\nbetter\tO\nthan\tO\na\tO\nChromebook\tO\n!\tO\n\nAdditionally\tO\n,\tO\nthere\tO\nis\tO\nbarely\tO\na\tO\nventilation\tB-aspectTerm\nsystem\tI-aspectTerm\nin\tO\nthe\tO\ncomputer\tO\n,\tO\nand\tO\neven\tO\nthe\tO\nsimple\tO\nactivity\tO\nof\tO\nwatching\tB-aspectTerm\nvideos\tI-aspectTerm\nlet\tO\nalone\tO\nplaying\tB-aspectTerm\nsteam\tI-aspectTerm\ngames\tI-aspectTerm\ncauses\tO\nthe\tO\nlaptop\tO\nto\tO\nget\tO\nvery\tO\nvery\tO\nhot\tO\n,\tO\nand\tO\nin\tO\nfact\tO\nimpossible\tO\nto\tO\nkeep\tO\non\tO\nlap\tO\n.\tO\n\nAt\tO\n$\tO\n1899\tO\nto\tO\nstart\tO\n,\tO\nthis\tO\nis\tO\nno\tO\ncheap\tO\nmachine\tO\n.\tO\n\nChatting\tO\nwith\tO\nAcer\tB-aspectTerm\nsupport\tI-aspectTerm\n,\tO\nI\tO\nwas\tO\nadvised\tO\nthe\tO\nproblem\tO\nwas\tO\ncorrupted\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nfiles\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nbeen\tO\na\tO\ncouple\tO\nweeks\tO\nsince\tO\nthe\tO\npurchase\tO\nand\tO\nI\tO\n'm\tO\nstruggle\tO\nwith\tO\nfinding\tO\nthe\tO\ncorrect\tO\nkeys\tB-aspectTerm\n(\tO\nbut\tO\nthat\tO\nwas\tO\nexpected\tO\n)\tO\n.\tO\n\nMany\tO\npeople\tO\ncomplain\tO\nabout\tO\nthe\tO\nnew\tO\nOS\tB-aspectTerm\n,\tO\nand\tO\nit\tO\n's\tO\nurgent\tO\nfor\tO\nApple\tO\nto\tO\nfix\tO\nit\tO\nasap\tO\n!\tO\n\nNow\tO\nthat\tO\nI\tO\nhave\tO\nupgraded\tO\nto\tO\nLion\tB-aspectTerm\nI\tO\nam\tO\nmuch\tO\nhappier\tO\nabout\tO\nMAC\tB-aspectTerm\nOS\tI-aspectTerm\nand\tO\nhave\tO\njust\tO\nbought\tO\nan\tO\niMac\tO\nfor\tO\noffice\tO\n.\tO\n\nUser\tO\nupgradeable\tO\nRAM\tB-aspectTerm\nand\tO\nHDD\tB-aspectTerm\n.\tO\n\nBut\tO\nI\tO\nwanted\tO\nthe\tO\nPro\tO\nfor\tO\nthe\tO\nCD\tB-aspectTerm\n/\tI-aspectTerm\nDVD\tI-aspectTerm\nplayer\tI-aspectTerm\n.\tO\n\nI\tO\nmight\tO\nhave\tO\nread\tO\nit\tO\nincorrectly\tO\n,\tO\nbut\tO\nbetter\tO\nsafe\tO\nthan\tO\nsorry\tO\nright\tO\n?\tO\n\nThe\tO\nultimate\tO\ngraduation\tO\ngift\tO\n.\tO\n\nThe\tO\nRAM\tB-aspectTerm\nmemory\tI-aspectTerm\nis\tO\ngood\tO\nbut\tO\nshould\tO\nhave\tO\nsplurged\tO\nfor\tO\n8Mb\tO\ninstead\tO\nof\tO\n4Mb\tO\n.\tO\n\nwas\tO\ndebating\tO\nto\tO\nbuy\tO\none\tO\nfor\tO\nmonths\tO\n,\tO\nchecked\tO\nout\tO\ndifferent\tO\nstuff\tO\non\tO\nyoutube\tO\n,\tO\nand\tO\nread\tO\ndifferent\tO\narticles\tO\nand\tO\ndebates\tO\n,\tO\nI\tO\njust\tO\ndid\tO\nnt\tO\nreally\tO\nwanna\tO\nspend\tO\nthe\tO\nmoney\tO\nbut\tO\nI\tO\nm\tO\nglad\tO\nthat\tO\nI\tO\ndid\tO\n.\tO\n\nI\tO\nlove\tO\nit\tO\nand\tO\nwould\tO\nrecommend\tO\nit\tO\nto\tO\neveryone\tO\nwho\tO\nis\tO\ntired\tO\nof\tO\nthe\tO\nconstant\tO\nattention\tO\nPC\tO\n's\tO\nrequire\tO\n.\tO\n\nI\tO\nwas\tO\na\tO\nlittle\tO\nworry\tO\nat\tO\nfirst\tO\nbecause\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\na\tO\nlot\tO\nof\tO\nexperience\tO\nwith\tO\nos.x\tB-aspectTerm\nand\tO\nwindows\tB-aspectTerm\nhas\tO\nalways\tO\nbeen\tO\nsecond\tO\nnature\tO\nto\tO\nme\tO\nafter\tO\nmany\tO\nyears\tO\nof\tO\nusing\tO\nwindows\tB-aspectTerm\n.\tO\n\nI\tO\nam\tO\nan\tO\nInfo\tO\nSys\tO\nmajor\tO\nin\tO\ncollege\tO\n,\tO\nso\tO\nI\tO\nstarted\tO\nresearching\tO\nthis\tO\nissue\tO\non\tO\nmy\tO\nown\tO\n.\tO\n\nSolution\tO\n:\tO\nit\tO\nturned\tO\nout\tO\nto\tO\nbe\tO\npretty\tO\nsimple\tO\n.\tO\n\nWith\tO\nthe\tO\nsoftwares\tB-aspectTerm\nsupporting\tO\nthe\tO\nuse\tO\nof\tO\nother\tO\nOS\tB-aspectTerm\nmakes\tO\nit\tO\nmuch\tO\nbetter\tO\n.\tO\n\nStill\tO\nhave\tO\nn't\tO\nsolved\tO\nthis\tO\n.\tO\n\nI\tO\nthen\tO\nupgraded\tO\nto\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nX\tI-aspectTerm\n10.8\tI-aspectTerm\n\"\tI-aspectTerm\nMountain\tI-aspectTerm\nLion\tI-aspectTerm\n\"\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nEXTREMELY\tO\nfast\tO\nand\tO\nnever\tO\nlags\tO\n.\tO\n\nI\tO\ntold\tO\nthem\tO\nthat\tO\nI\tO\njust\tO\nreceived\tO\nmy\tO\nbrand\tO\nnew\tO\nMacBook\tO\nbut\tO\nI\tO\nwas\tO\nhaving\tO\nissues\tO\n.\tO\n\nI\tO\nwas\tO\nconsidering\tO\nbuying\tO\nthe\tO\nAir\tO\n,\tO\nbut\tO\nin\tO\nreality\tO\n,\tO\nthis\tO\none\tO\nhas\tO\na\tO\nmore\tO\npowerful\tO\nperformance\tB-aspectTerm\nand\tO\nseems\tO\nmuch\tO\nmore\tO\nconvenient\tO\n,\tO\neven\tO\nthough\tO\nit\tO\n's\tO\nabout\tO\n.20\tO\ninch\tO\nthicker\tO\nand\tO\n2\tO\nlbs\tO\nheavier\tO\n.\tO\n\nAt\tO\nhome\tO\nand\tO\nthe\tO\noffice\tO\nit\tO\ngets\tO\nplugged\tO\ninto\tO\nan\tO\nexternal\tB-aspectTerm\n24\tI-aspectTerm\n\"\tI-aspectTerm\nLCD\tI-aspectTerm\nscreen\tI-aspectTerm\n,\tO\nso\tO\nbuilt\tB-aspectTerm\nin\tI-aspectTerm\nscreen\tI-aspectTerm\nsize\tI-aspectTerm\nis\tO\nnot\tO\nterribly\tO\nimportant\tO\n.\tO\n\nHopefully\tO\nmy\tO\nreplacement\tO\nis\tO\nbrand\tO\nnew\tO\n.\tO\n\nJust\tO\nbeware\tO\nno\tO\nDVD\tB-aspectTerm\nslot\tI-aspectTerm\nso\tO\nwhen\tO\nI\tO\nwent\tO\nto\tO\ninstall\tB-aspectTerm\nsoftware\tI-aspectTerm\nI\tO\nhad\tO\non\tO\nCD\tO\nI\tO\ncould\tO\nn't\tO\n.\tO\n\nI\tO\nbought\tO\nit\tO\nto\tO\nbe\tO\nable\tO\nto\tO\ndedicate\tO\na\tO\nsmall\tO\n,\tO\nportable\tO\nlaptop\tO\nto\tO\nmy\tO\nwriting\tO\nand\tO\nwas\tO\nsurprised\tO\nto\tO\nlearn\tO\nthat\tO\nI\tO\nneeded\tO\nto\tO\nbuy\tO\na\tO\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\nprogram\tI-aspectTerm\nto\tO\ndo\tO\nso\tO\n.\tO\n\nThis\tO\nversion\tO\nof\tO\nMacBook\tO\nPro\tO\nruns\tO\non\tO\na\tO\nthird\tB-aspectTerm\n-\tI-aspectTerm\ngeneration\tI-aspectTerm\nCPU\tI-aspectTerm\n(\tI-aspectTerm\n\"\tI-aspectTerm\nIvy\tI-aspectTerm\nBridge\tI-aspectTerm\n\"\tI-aspectTerm\n)\tI-aspectTerm\n,\tO\nnot\tO\nthe\tO\nlatest\tO\nfourth\tB-aspectTerm\n-\tI-aspectTerm\ngeneration\tI-aspectTerm\nHaswell\tI-aspectTerm\nCPU\tI-aspectTerm\nthe\tO\n2013\tO\nversion\tO\nhas\tO\n.\tO\n\nActually\tO\n,\tO\nI\tO\nthink\tO\nI\tO\nwas\tO\nintimidated\tO\nby\tO\nthe\tO\nchange\tO\nfrom\tO\na\tO\nPC\tO\n.\tO\n\nNo\tO\nCd\tB-aspectTerm\nRom\tI-aspectTerm\nin\tO\nthe\tO\nnew\tO\nversion\tO\nthere\tO\n's\tO\nno\tO\nway\tO\nI\tO\n'm\tO\nspending\tO\nthat\tO\nkind\tO\nof\tO\nmoney\tO\non\tO\nsomething\tO\nhas\tO\nless\tO\nfeatures\tB-aspectTerm\nthan\tO\nthe\tO\nolder\tO\nversion\tO\n.\tO\n\nDefinitely\tO\nworth\tO\nspending\tO\nthe\tO\nmoney\tO\non\tO\nit\tO\n.\tO\n\nI\tO\nhave\tO\nthree\tO\nwords\tO\n:\tO\nPiece\tO\nof\tO\nJunk\tO\n!\tO\n\nthe\tO\nvolume\tB-aspectTerm\nis\tO\nreally\tO\nlow\tO\nto\tO\nlow\tO\nfor\tO\na\tO\nlaptopwas\tO\nnot\tO\nexpectin\tO\nt\tO\nvolume\tB-aspectTerm\nto\tO\nbe\tO\nso\tO\nlowan\tO\ni\tO\nhate\tO\nthat\tO\nabout\tO\nthis\tO\ncomputer\tO\n\nFits\tO\nall\tO\nmy\tO\npersonal\tO\nneeds\tO\n.\tO\n\nI\tO\n'm\tO\nthe\tO\npro\tO\n-\tO\nactive\tO\ntype\tO\nso\tO\nI\tO\nwent\tO\noff\tO\nand\tO\ndid\tO\nsome\tO\npreventative\tO\nfixes\tO\n.\tO\n\nand\tO\nits\tO\nnot\tO\nhard\tO\nto\tO\naccidentally\tO\nbang\tO\nit\tO\nagainst\tO\nsomething\tO\nso\tO\ni\tO\nrecommend\tO\ngetting\tO\na\tO\ncase\tB-aspectTerm\nto\tO\nprotect\tO\nit\tO\n.\tO\n\nI\tO\nwanted\tO\nto\tO\nexplore\tO\nwhat\tO\nthe\tO\nMac\tO\nwas\tO\nall\tO\nabout\tO\n.\tO\n\nI\tO\ngot\tO\nthis\tO\nat\tO\nan\tO\namazing\tO\nprice\tB-aspectTerm\nfrom\tO\nAmazon\tO\nand\tO\nit\tO\narrived\tO\njust\tO\nin\tO\ntime\tO\n.\tO\n\nEvery\tO\ntime\tO\nI\tO\nlog\tB-aspectTerm\ninto\tI-aspectTerm\nthe\tI-aspectTerm\nsystem\tI-aspectTerm\nafter\tO\na\tO\nfew\tO\nhours\tO\n,\tO\nthere\tO\nis\tO\nthis\tO\nendlessly\tO\nfrustrating\tO\nprocess\tO\nthat\tO\nI\tO\nhave\tO\nto\tO\ngo\tO\nthrough\tO\n.\tO\n\nThe\tO\nmajority\tO\nof\tO\nthe\tO\nreviews\tO\nseem\tO\nto\tO\nbe\tO\nfor\tO\nthe\tO\n13.3\tO\nMacBook\tO\nPro\tO\nModel\tO\n#\tO\nMD101LL\tO\n/\tO\nA.\tO\n\nPut\tO\na\tO\nSSD\tB-aspectTerm\nand\tO\nuse\tO\na\tO\n21\tB-aspectTerm\n\"\tI-aspectTerm\nLED\tI-aspectTerm\nscreen\tI-aspectTerm\n,\tO\nthis\tO\nset\tB-aspectTerm\nup\tI-aspectTerm\nis\tO\nsilky\tO\nsmooth\tO\n!\tO\n\nI\tO\nsaw\tO\nthe\tO\nbad\tO\nreviews\tO\nfrom\tO\npeople\tO\nsaying\tO\nto\tO\nbuy\tO\ndirectly\tO\nfrom\tO\nApple\tO\nand\tO\nI\tO\nwas\tO\nconcerned\tO\nbut\tO\nI\tO\ntook\tO\nmy\tO\nchances\tO\nand\tO\nam\tO\noverly\tO\nimpressed\tO\n.\tO\n\nThe\tO\ncase\tB-aspectTerm\nis\tO\nnow\tO\nslightly\tO\nlarger\tO\nthan\tO\nthe\tO\nprevious\tO\ngeneration\tO\n,\tO\nbut\tO\nthe\tO\nlack\tO\nof\tO\nan\tO\nexternal\tB-aspectTerm\npower\tI-aspectTerm\nsupply\tI-aspectTerm\njustifies\tO\nthe\tO\nsmall\tO\nincrease\tO\nin\tO\nsize\tB-aspectTerm\n.\tO\n\nI\tO\nhad\tO\nto\tO\nbuy\tO\na\tO\nwireless\tB-aspectTerm\nmouse\tI-aspectTerm\nto\tO\ngo\tO\nwith\tO\nit\tO\n,\tO\nas\tO\nI\tO\nam\tO\nold\tO\nschool\tO\nand\tO\nhate\tO\nthe\tO\npad\tB-aspectTerm\n,\tO\nbut\tO\nknew\tO\nthat\tO\nbefore\tO\nI\tO\nbought\tO\nit\tO\n,\tO\nnow\tO\nit\tO\nworks\tB-aspectTerm\ngreat\tO\n,\tO\nneed\tO\nto\tO\nget\tO\nadjusted\tO\nto\tO\nthe\tO\nkey\tB-aspectTerm\nboard\tI-aspectTerm\n,\tO\nas\tO\nI\tO\nam\tO\nused\tO\nto\tO\na\tO\nbigger\tO\none\tO\nand\tO\npounding\tO\n.\tO\n\nWhen\tO\nconsidering\tO\na\tO\nMac\tO\n,\tO\nlook\tO\nat\tO\nthe\tO\ntotal\tO\ncost\tB-aspectTerm\nof\tI-aspectTerm\nownership\tI-aspectTerm\nand\tO\nnot\tO\njust\tO\nthe\tO\ninitial\tO\nprice\tB-aspectTerm\ntag\tI-aspectTerm\n.\tO\n\nHas\tO\nall\tO\nthe\tO\nother\tO\nfeatures\tB-aspectTerm\nI\tO\nwanted\tO\nincluding\tO\na\tO\nVGA\tB-aspectTerm\nport\tI-aspectTerm\n,\tO\nHDMI\tB-aspectTerm\n,\tO\nethernet\tB-aspectTerm\nand\tO\n3\tO\nUSB\tB-aspectTerm\nports\tI-aspectTerm\n.\tO\n\nA\tO\ngreat\tO\ncollege\tO\ntool\tO\n!\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\ndislike\tO\nabout\tO\nthis\tO\nlaptop\tO\nare\tO\nthe\tO\nrubber\tB-aspectTerm\npads\tI-aspectTerm\nfound\tO\non\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\ncomputer\tO\nfor\tO\ngrip\tO\n.\tO\n\nI\tO\ncalled\tO\napple\tO\nand\tO\nno\tO\nsolution\tO\n.\tO\n\nIt\tO\n's\tO\na\tO\ndecent\tO\ncomputer\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\nand\tO\nhopefully\tO\nit\tO\nwill\tO\nlast\tO\na\tO\nlong\tO\ntime\tO\n.\tO\n\nI\tO\nwas\tO\nreally\tO\nhappy\tO\nbecause\tO\nit\tO\nis\tO\na\tO\nmuch\tO\nbetter\tO\nprice\tB-aspectTerm\non\tO\namazon.com\tO\nthan\tO\nit\tO\nwas\tO\nin\tO\nthe\tO\nMac\tO\nstore\tO\n.\tO\n\nThe\tO\nworst\tO\na\tO\nMac\tO\never\tO\ndid\tO\nto\tO\nme\tO\nwas\tO\nfreeze\tO\nup\tO\n.\tO\n\nThe\tO\nnicest\tO\npart\tO\nis\tO\nthe\tO\nlow\tO\nheat\tO\noutput\tB-aspectTerm\nand\tO\nultra\tO\nquiet\tO\noperation\tO\n.\tB-aspectTerm\n\nI\tO\nam\tO\npaying\tO\napple\tO\nto\tO\nkill\tO\nmy\tO\nself\tO\nand\tO\nmy\tO\nwallet\tO\n.\tO\n\nNO\tO\nSTAR\tO\nFOR\tO\nTHIS\tO\nTRASH\tO\n.\tO\n[\tO\n...\tO\n\nI\tO\nwill\tO\nupgrade\tB-aspectTerm\nthe\tI-aspectTerm\nram\tI-aspectTerm\nmyself\tO\n(\tO\nbecause\tO\nwith\tO\nthis\tO\nmodel\tO\nyou\tO\ncan\tO\nyou\tO\ncan\tO\ndo\tO\nit\tO\n)\tO\nlater\tO\non\tO\n.\tO\n\nThe\tO\nprice\tB-aspectTerm\nis\tO\n200\tO\ndollars\tO\ndown\tO\n.\tO\n\nthis\tO\nMac\tO\nMini\tO\ndoes\tO\nnot\tO\nhave\tO\na\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nmic\tI-aspectTerm\n,\tO\nand\tO\nit\tO\nwould\tO\nseem\tO\nthat\tO\nits\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\n10.9\tI-aspectTerm\ndoes\tO\nnot\tO\nhandle\tO\nexternal\tB-aspectTerm\nmicrophones\tI-aspectTerm\nproperly\tO\n.\tO\n\nA\tO\nlot\tO\nof\tO\nfeatures\tB-aspectTerm\nand\tO\nshortcuts\tB-aspectTerm\non\tO\nthe\tO\nMBP\tO\nthat\tO\nI\tO\nwas\tO\nnever\tO\nexposed\tO\nto\tO\non\tO\na\tO\nnormal\tO\nPC\tO\n.\tO\n\nWas\tO\nn't\tO\nsure\tO\nif\tO\nI\tO\nwas\tO\ngoing\tO\nto\tO\nlike\tO\nit\tO\nmuch\tO\nless\tO\nlove\tO\nit\tO\nso\tO\nI\tO\nwent\tO\nto\tO\na\tO\nlocal\tO\nbest\tO\nbuy\tO\nand\tO\nplayed\tO\naround\tO\nwith\tO\nthe\tO\nIOS\tB-aspectTerm\nsystem\tI-aspectTerm\non\tO\na\tO\nMac\tO\nPro\tO\nand\tO\nit\tO\nwas\tO\ntotally\tO\nunique\tO\nand\tO\ndifferent\tO\n.\tO\n\nQuietest\tO\nlaptop\tO\nI\tO\nhave\tO\never\tO\nowned\tO\n.\tO\n\nair\tO\nhas\tO\nhigher\tO\nresolution\tB-aspectTerm\nbut\tO\nthe\tO\nfonts\tB-aspectTerm\nare\tO\nsmall\tO\n.\tO\n\nagain\tO\nthis\tO\nis\tO\njust\tO\nmy\tO\npersonal\tO\nhonest\tO\nopinion\tO\n.\tO\n\nIf\tO\nyou\tO\nhave\tO\nmuch\tO\nhigher\tO\nexpectations\tO\nthan\tO\nthat\tO\n...\tO\nI\tO\nwould\tO\nlook\tO\nelsewhere\tO\n.\tO\n\nworking\tB-aspectTerm\nwith\tO\nMac\tO\nis\tO\nso\tO\nmuch\tO\neasier\tO\n,\tO\nso\tO\nmany\tO\ncool\tO\nfeatures\tB-aspectTerm\n.\tO\n\nI\tO\n'm\tO\ngoing\tO\nto\tO\nbuy\tO\na\tO\nlogitevh\tO\nc270\tO\n.\tO\n\nVery\tO\nhappy\tO\nwith\tO\nmy\tO\npurchase\tO\n.\tO\n\nI\tO\nlike\tO\nthe\tO\nbrightness\tB-aspectTerm\nand\tO\nadjustments\tB-aspectTerm\n.\tO\n\nI'M\tO\nSO\tO\nHAPPY\tO\nWITH\tO\nMY\tO\nmacbook\tO\npro\tO\n!\tO\n\nI\tO\nonly\tO\nwish\tO\nthis\tO\nmac\tO\nhad\tO\na\tO\nCD\tB-aspectTerm\n/\tI-aspectTerm\nDVD\tI-aspectTerm\nplayer\tI-aspectTerm\nbuilt\tO\nin\tO\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\nmiss\tO\nis\tO\nthat\tO\nmy\tO\nold\tO\nAlienware\tO\nlaptop\tO\nhad\tO\nbacklit\tB-aspectTerm\nkeys\tI-aspectTerm\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\nmiss\tO\nare\tO\nthe\tO\n\"\tB-aspectTerm\nHome\tI-aspectTerm\n/\tI-aspectTerm\nEnd\tI-aspectTerm\n\"\tI-aspectTerm\ntype\tI-aspectTerm\nkeys\tI-aspectTerm\nand\tO\nother\tO\nthings\tO\nthat\tO\nI\tO\ngrew\tO\naccustomed\tO\nto\tO\nafter\tO\nso\tO\nlong\tO\n.\tO\n\nSo\tO\nhappy\tO\nwith\tO\nthis\tO\npurchase\tO\n,\tO\nI\tO\njust\tO\nwish\tO\nit\tO\ncame\tO\nwith\tO\nMicrosoft\tB-aspectTerm\nWord\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nmore\tO\nthan\tO\nenough\tO\ncomputer\tO\nto\tO\nkeep\tO\nup\tO\nwith\tO\nthe\tO\nneeds\tO\nof\tO\na\tO\nhigh\tO\nschool\tO\nstudent\tO\n.\tO\n\nIt\tO\nhas\tO\nenough\tO\nmemory\tB-aspectTerm\nand\tO\nspeed\tB-aspectTerm\nto\tO\nrun\tO\nmy\tO\nbusiness\tO\nwith\tO\nall\tO\nthe\tO\nflexibility\tB-aspectTerm\nthat\tO\ncomes\tO\nwith\tO\na\tO\nlaptop\tO\n.\tO\n\nThe\tO\nspeed\tB-aspectTerm\n,\tO\nthe\tO\nsimplicity\tB-aspectTerm\n,\tO\nthe\tO\ndesign\tB-aspectTerm\n..\tO\nit\tO\nis\tO\nlightyears\tO\nahead\tO\nof\tO\nany\tO\nPC\tO\nI\tO\nhave\tO\never\tO\nowned\tO\n.\tO\n\nI\tO\nlove\tO\neverything\tO\nabout\tO\nthis\tO\ncomputer\tO\n.\tO\n\nI\tO\nfound\tO\nit\tO\ntoughest\tO\nto\tO\ndecide\tO\nbetween\tO\nDell\tO\nultra\tO\nbooks\tO\nand\tO\nApple\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nexcellent\tO\n,\tO\nthe\tO\ndisplay\tB-aspectTerm\nis\tO\nexcellent\tO\n,\tO\nand\tO\ndownloading\tB-aspectTerm\napps\tI-aspectTerm\nis\tO\na\tO\nbreeze\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\n,\tO\nthe\tO\nsoftware\tB-aspectTerm\nand\tO\nthe\tO\nsmoothness\tO\nof\tO\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n.\tO\n\nWhile\tO\nwe\tO\nstruggle\tO\nwith\tO\nall\tO\nthe\tO\ncrashes\tO\nand\tO\nviruses\tO\n,\tO\nthe\tO\nkids\tO\ncomputers\tO\nstay\tO\nconsistent\tO\nand\tO\nso\tO\nwe\tO\ncaved\tO\nin\tO\nand\tO\nbought\tO\none\tO\nfor\tO\nbuisness\tO\n!\tO\n\nI\tO\ndo\tO\nn't\tO\nwant\tO\nto\tO\nRUN\tO\na\tO\ncomputer\tO\n;\tO\nI\tO\nwant\tO\nto\tO\nUSE\tO\na\tO\ncomputer\tO\n.\tO\n\ni\tO\nhave\tO\ndropped\tO\nmine\tO\na\tO\ncouple\tO\ntimes\tO\nwith\tO\nonly\tO\na\tO\nslim\tB-aspectTerm\nplastic\tI-aspectTerm\ncase\tI-aspectTerm\ncovering\tO\nit\tO\n.\tO\n\nI\tO\nalso\tO\nmade\tO\na\tO\nrecovery\tB-aspectTerm\nUSB\tI-aspectTerm\nstick\tI-aspectTerm\n.\tO\n\nBeing\tO\na\tO\nPC\tO\nuser\tO\nfor\tO\nmany\tO\nyears\tO\nto\tO\nswitch\tO\nto\tO\na\tO\nMac\tO\nI\tO\nwill\tO\nnot\tO\ngo\tO\nback\tO\n.\tO\n\nBut\tO\nwith\tO\nthis\tO\nlaptop\tO\n,\tO\nthe\tO\nbass\tB-aspectTerm\nis\tO\nvery\tO\nweak\tO\nand\tO\nthe\tO\nsound\tB-aspectTerm\ncomes\tO\nout\tO\nsounding\tO\ntinny\tO\n.\tO\n\nI\tO\ndo\tO\nadmit\tO\nit\tO\nis\tO\npricey\tO\nbut\tO\nthe\tO\nsaying\tO\nis\tO\nreally\tO\ntrue\tO\nwith\tO\nthis\tO\nMacBook\tO\nPro\tO\nLaptop\tO\n(\tO\nYou\tO\nget\tO\nwhat\tO\nyou\tO\npay\tO\nfor\tO\n)\tO\n.\tO\n\nI\tO\n've\tO\nalmost\tO\nhave\tO\nbought\tO\nevery\tO\ngeneration\tO\nof\tO\nMacMinis\tO\nsince\tO\n2005\tO\n,\tO\nand\tO\nthis\tO\none\tO\nhas\tO\nn't\tO\nlet\tO\nme\tO\ndown\tO\n.\tO\n\nThe\tO\nbuilt\tB-aspectTerm\nquality\tI-aspectTerm\nis\tO\nreally\tO\ngood\tO\n,\tO\nI\tO\nwas\tO\nso\tO\nHappy\tO\nand\tO\nexcited\tO\nabout\tO\nthis\tO\nProduct\tO\n.\tO\n\nI\tO\nam\tO\nloving\tO\nthe\tO\nfast\tO\nperformance\tB-aspectTerm\nalso\tO\n.\tO\n\nI\tO\nhad\tO\nto\tO\nreturn\tO\nit\tO\nbecause\tO\nit\tO\nwould\tO\nn't\tO\neven\tO\nstart\tO\n.\tO\n\nFurther\tO\n,\tO\nthis\tO\nMac\tO\nMini\tO\nhas\tO\na\tO\nsloppy\tO\nBluetooth\tB-aspectTerm\ninterface\tI-aspectTerm\n(\tO\ncourtesy\tO\nof\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\n)\tO\nand\tO\nthe\tO\nrange\tB-aspectTerm\nis\tO\npoor\tO\n.\tO\n\nGreat\tO\ndeal\tO\non\tO\nan\tO\namazing\tO\nlap\tO\ntop\tO\n!\tO\n\nIf\tO\nyou\tO\nstart\tO\non\tO\nthe\tO\nfar\tO\nright\tO\nside\tO\nand\tO\nscroll\tO\nto\tO\nyour\tO\nleft\tO\nthe\tO\nstart\tB-aspectTerm\nmenu\tI-aspectTerm\nwill\tO\nautomatically\tO\ncome\tO\nup\tO\n.\tO\n\nBest\tO\nmoney\tO\nI\tO\never\tO\nspent\tO\n.\tO\n\nMy\tO\nonly\tO\ngripe\tO\nwould\tO\nbe\tO\nthe\tO\nneed\tO\nto\tO\nadd\tO\nmore\tO\nRAM\tB-aspectTerm\n.\tO\n\nBut\tO\nI\tO\ndid\tO\nn't\tO\nwant\tO\nto\tO\nspend\tO\nanother\tO\nthousand\tO\non\tO\na\tO\nlaptop\tO\nsince\tO\nmy\tO\nwork\tO\nalready\tO\nprovides\tO\nme\tO\nwith\tO\na\tO\nPC\tO\n.\tO\n\nFine\tO\nif\tO\nyou\tO\nhave\tO\na\tO\ntouch\tB-aspectTerm\nscreen\tI-aspectTerm\n.\tO\n\ncan\tO\nnever\tO\ngo\tO\nwrong\tO\nwith\tO\napple\tO\nproducts\tO\n.\tO\n\nAs\tO\nfar\tO\nas\tO\nuser\tO\ntype\tO\n-\tO\nI\tO\ndabble\tO\nin\tO\neverything\tO\nfrom\tO\ngames\tB-aspectTerm\n(\tO\nWoW\tO\n)\tO\nto\tO\nPhotoshop\tB-aspectTerm\n,\tO\nbut\tO\nnothing\tO\nprofessionally\tO\n.\tO\n\nIt\tO\ndoes\tO\nnt\tO\nget\tO\nhot\tO\nlike\tO\nmy\tO\nPC\tO\n,\tO\nwith\tO\ntechnology\tO\nalways\tO\nat\tO\nthe\tO\ntip\tO\nof\tO\nour\tO\nfingertips\tO\nanytime\tO\nI\tO\nforget\tO\nhow\tO\nto\tO\ndo\tO\nsomething\tO\ni\tO\njust\tO\ngoogle\tO\nit\tO\n.\tO\n\nI\tO\nre\tO\n-\tO\nseated\tO\nthe\tO\n\"\tB-aspectTerm\nWLAN\tI-aspectTerm\n\"\tI-aspectTerm\ncard\tI-aspectTerm\ninside\tO\nand\tO\nre\tO\n-\tO\ninstalled\tO\nthe\tO\nLAN\tB-aspectTerm\ndevice\tI-aspectTerm\ndrivers\tI-aspectTerm\n.\tO\n\nThis\tO\nby\tO\nfar\tO\nbeats\tO\nany\tO\ncomputer\tO\nout\tO\non\tO\nthe\tO\nmarket\tO\ntoday\tO\nbuilt\tB-aspectTerm\nwell\tO\n,\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nAMAZING\tO\n.\tO\n\nI\tO\nhave\tO\nn't\tO\nused\tO\nit\tO\nfor\tO\nanything\tO\nhigh\tO\ntech\tO\nyet\tO\n,\tO\nbut\tO\nI\tO\nlove\tO\nit\tO\nalready\tO\n.\tO\n\nThe\tO\nOS\tB-aspectTerm\nis\tO\neasy\tO\n,\tO\nand\tO\noffers\tO\nall\tO\nkinds\tO\nof\tO\nsurprises\tO\n.\tO\n\nI\tO\nhad\tO\nto\tO\nget\tO\nApple\tB-aspectTerm\nCustomer\tI-aspectTerm\nSupport\tI-aspectTerm\nto\tO\ncorrect\tO\nthe\tO\nproblem\tO\n.\tO\n\nIdeal\tO\nfor\tO\nsomeone\tO\non\tO\nthe\tO\ngo\tO\nor\tO\nfor\tO\na\tO\nhigh\tO\nschool\tO\nstudents\tO\n.\tO\n\nA\tO\nveryimportant\tO\nfeature\tO\nis\tO\nFirewire\tB-aspectTerm\n800\tI-aspectTerm\nwhich\tO\nin\tO\nmy\tO\nexperience\tO\nworks\tO\nbetter\tO\nthen\tO\nUSB3\tB-aspectTerm\n(\tO\nin\tO\nPC\tO\nenabled\tO\nwith\tO\nUSB3)I\tB-aspectTerm\nwas\tO\nnot\tO\noriginally\tO\nsold\tO\non\tO\nthe\tO\nMAC\tB-aspectTerm\nOS\tI-aspectTerm\nI\tO\nfelt\tO\nit\tO\nwas\tO\ninferior\tO\nin\tO\nmany\tO\nways\tO\nTo\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\n.\tO\n\nI\tO\nlike\tO\niTunes\tB-aspectTerm\n,\tO\nthe\tO\napparent\tO\nsecurity\tB-aspectTerm\n,\tO\nthe\tO\nMini\tB-aspectTerm\nform\tI-aspectTerm\nfactor\tI-aspectTerm\n,\tO\nall\tO\nthe\tO\nnice\tO\ngraphics\tB-aspectTerm\nstuff\tI-aspectTerm\n.\tO\n\nThe\tO\nfirst\tO\ntime\tO\nI\tO\nused\tO\nthe\tO\ncard\tB-aspectTerm\nreader\tI-aspectTerm\nit\tO\ntook\tO\nhalf\tO\nan\tO\nhour\tO\nand\tO\na\tO\npair\tO\nof\tO\ntweezers\tO\nto\tO\nremove\tB-aspectTerm\nthe\tI-aspectTerm\ncard\tI-aspectTerm\n.\tO\n\nThis\tO\nflaw\tO\nunfortunately\tO\ndetracts\tO\nfrom\tO\neverything\tO\nelse\tO\nApple\tO\ngot\tO\nright\tO\nwith\tO\nthe\tO\nMini\tO\n.\tO\n\nAfter\tO\nreplacing\tO\nthe\tO\nspinning\tB-aspectTerm\nhard\tI-aspectTerm\ndisk\tI-aspectTerm\nwith\tO\nan\tO\nssd\tB-aspectTerm\ndrive\tI-aspectTerm\n,\tO\nmy\tO\nmac\tO\nis\tO\njust\tO\nflying\tO\n.\tO\n\nI\tO\nknow\tO\nsome\tO\npeople\tO\ncomplained\tO\nabout\tO\nHDMI\tB-aspectTerm\nissues\tO\nbut\tO\nthey\tO\nreleased\tO\na\tO\nfirmware\tB-aspectTerm\npatch\tI-aspectTerm\nto\tO\naddress\tO\nthat\tO\nissue\tO\n.\tO\n\nWith\tO\nthe\tO\nneeds\tO\nof\tO\na\tO\nprofessional\tO\nphotographer\tO\nI\tO\ngenerally\tO\nneed\tO\nto\tO\nkeep\tO\nup\tO\nwith\tO\nthe\tO\nbest\tO\nspecs\tB-aspectTerm\n.\tO\n\nAdded\tO\nan\tO\niMac\tO\nabout\tO\n2\tO\nyears\tO\nlater\tO\n.\tO\n\npacking\tB-aspectTerm\nand\tO\neverything\tO\nwas\tO\nperfect\tO\n\nI\tO\nwill\tO\nnot\tO\nhesitate\tO\nto\tO\nrecommend\tO\nit\tO\nto\tO\nfamily\tO\nand\tO\nfriends\tO\n\nI\tO\ncalled\tO\nToshiba\tO\nwhere\tO\nI\tO\ngave\tO\nthem\tO\nthe\tO\nserial\tO\nnumber\tO\nand\tO\nthey\tO\ninformed\tO\nme\tO\nthat\tO\nthey\tO\nwere\tO\nhaving\tO\nissues\tO\nwith\tO\nthe\tO\nmother\tB-aspectTerm\nboards\tI-aspectTerm\n.\tO\n\nI\tO\nseem\tO\nto\tO\nbe\tO\nhaving\tO\nrepeat\tO\nproblems\tO\nas\tO\nthe\tO\nMother\tB-aspectTerm\nBoard\tI-aspectTerm\nin\tO\nthis\tO\none\tO\nis\tO\ndiagnosed\tO\nas\tO\nfaulty\tO\n,\tO\nrelated\tO\nto\tO\nthe\tO\ngraphics\tB-aspectTerm\ncard\tI-aspectTerm\n.\tO\n\nIt\tO\nalso\tO\ncomes\tO\nwith\tO\n4\tB-aspectTerm\nG\tI-aspectTerm\nof\tI-aspectTerm\nRAM\tI-aspectTerm\nbut\tO\nif\tO\nyou\tO\n're\tO\nlike\tO\nme\tO\nyou\tO\nwant\tO\nto\tO\nmax\tO\nthat\tO\nout\tO\nso\tO\nI\tO\nimmediately\tO\nput\tO\n8\tB-aspectTerm\nG\tI-aspectTerm\nof\tI-aspectTerm\nRAM\tI-aspectTerm\nin\tO\nher\tO\nand\tO\nI\tO\n've\tO\nnever\tO\nused\tO\na\tO\ncomputer\tO\nthat\tO\nperforms\tB-aspectTerm\nbetter\tO\n.\tO\n\nThis\tO\ncomputer\tO\nis\tO\nalso\tO\nawesome\tO\nfor\tO\nmy\tO\nsons\tO\nvirtual\tB-aspectTerm\nhome\tI-aspectTerm\nschooling\tI-aspectTerm\n.\tO\n\nCost\tB-aspectTerm\nis\tO\nmore\tO\nas\tO\ncompared\tO\nto\tO\nother\tO\nbrands\tO\n.\tO\n\nalso\tO\n...\tO\n-\tO\nexcellent\tO\noperating\tB-aspectTerm\nsystem-\tI-aspectTerm\nsize\tB-aspectTerm\nand\tO\nweight\tB-aspectTerm\nfor\tO\noptimal\tO\nmobility-\tB-aspectTerm\nexcellent\tO\ndurability\tB-aspectTerm\nof\tI-aspectTerm\nthe\tI-aspectTerm\nbattery-\tI-aspectTerm\nthe\tO\nfunctions\tB-aspectTerm\nprovided\tI-aspectTerm\nby\tI-aspectTerm\nthe\tI-aspectTerm\ntrackpad\tI-aspectTerm\nis\tO\nunmatched\tO\nby\tO\nany\tO\nother\tO\nbrand-\tO\n\nThis\tO\nhardware\tB-aspectTerm\nseems\tO\nto\tO\nbe\tO\nbetter\tO\nthan\tO\nthe\tO\niMac\tO\nin\tO\nthat\tO\nit\tO\nis\tO\nn't\tO\n$\tO\n1400\tO\nand\tO\nsmaller\tO\n.\tO\n\nI\tO\n'm\tO\ndone\tO\nwith\tO\nWinDoze\tO\ncomputers\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nit\tO\nfor\tO\nabout\tO\n2\tO\nmonths\tO\nnow\tO\nand\tO\nfound\tO\nno\tO\nissues\tO\nwith\tO\nsoftware\tB-aspectTerm\nor\tO\nupdates\tB-aspectTerm\n.\tO\n\nthe\tO\nlatest\tO\nversion\tO\ndoes\tO\nnot\tO\nhave\tO\na\tO\ndisc\tB-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nScreen\tB-aspectTerm\n-\tO\nalthough\tO\nsome\tO\npeople\tO\nmight\tO\ncomplain\tO\nabout\tO\nlow\tO\nres\tB-aspectTerm\nwhich\tO\nI\tO\nthink\tO\nis\tO\nridiculous\tO\n.\tO\n\n"
  },
  {
    "path": "dataset/Laptop-reviews/train.txt",
    "content": "I\tO\ncharge\tO\nit\tO\nat\tO\nnight\tO\nand\tO\nskip\tO\ntaking\tO\nthe\tO\ncord\tB-aspectTerm\nwith\tO\nme\tO\nbecause\tO\nof\tO\nthe\tO\ngood\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nI\tO\nbought\tO\na\tO\nHP\tO\nPavilion\tO\nDV4\tO\n-\tO\n1222nr\tO\nlaptop\tO\nand\tO\nhave\tO\nhad\tO\nso\tO\nmany\tO\nproblems\tO\nwith\tO\nthe\tO\ncomputer\tO\n.\tO\n\nThe\tO\ntech\tB-aspectTerm\nguy\tI-aspectTerm\nthen\tO\nsaid\tO\nthe\tO\nservice\tB-aspectTerm\ncenter\tI-aspectTerm\ndoes\tO\nnot\tO\ndo\tO\n1-to-1\tO\nexchange\tO\nand\tO\nI\tO\nhave\tO\nto\tO\ndirect\tO\nmy\tO\nconcern\tO\nto\tO\nthe\tO\n\"\tB-aspectTerm\nsales\tI-aspectTerm\n\"\tI-aspectTerm\nteam\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\nthe\tO\nretail\tO\nshop\tO\nwhich\tO\nI\tO\nbought\tO\nmy\tO\nnetbook\tO\nfrom\tO\n.\tO\n\nI\tO\ninvestigated\tO\nnetbooks\tO\nand\tO\nsaw\tO\nthe\tO\nToshiba\tO\nNB305-N410BL\tO\n.\tO\n\nThe\tO\nother\tO\nday\tO\nI\tO\nhad\tO\na\tO\npresentation\tO\nto\tO\ndo\tO\nfor\tO\na\tO\nseminar\tO\nat\tO\na\tO\nlarge\tO\nconference\tO\nin\tO\ntown-\tO\nlots\tO\nof\tO\npeople\tO\n,\tO\nlittle\tO\ntime\tO\nto\tO\nprep\tO\nand\tO\nhave\tO\nto\tO\nset\tO\nup\tO\na\tO\ncomputer\tO\nto\tO\na\tO\nprojector\tO\n,\tO\netc\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tB-aspectTerm\n,\tO\nhas\tO\na\tO\nkiller\tO\nGUI\tB-aspectTerm\n,\tO\nis\tO\nextremely\tO\nstable\tO\n,\tO\nis\tO\nhighly\tO\nexpandable\tO\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tB-aspectTerm\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nEasy\tO\nto\tO\nstart\tB-aspectTerm\nup\tI-aspectTerm\nand\tO\ndoes\tO\nnot\tO\noverheat\tO\nas\tO\nmuch\tO\nas\tO\nother\tO\nlaptops\tO\n.\tO\n\nSad\tO\nvery\tO\nSAD\tO\n.\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nfeatures\tB-aspectTerm\nthat\tO\nit\tO\noffers\tO\n,\tO\nlike\tO\n,\tO\niChat\tB-aspectTerm\n,\tO\nPhotobooth\tB-aspectTerm\n,\tO\ngarage\tB-aspectTerm\nband\tI-aspectTerm\nand\tO\nmore\tO\n!\tO\n\nNeedless\tO\nto\tO\nsay\tO\na\tO\nPC\tO\nthat\tO\nca\tO\nn't\tO\nsupport\tO\na\tO\ncell\tO\nphone\tO\nis\tO\nless\tO\nthan\tO\nuseless\tO\n!\tO\n\nGreat\tO\nlaptop\tO\nthat\tO\noffers\tO\nmany\tO\ngreat\tO\nfeatures\tB-aspectTerm\n!\tO\n\nthey\tO\nhave\tO\ndone\tO\nabsolutely\tO\nnothing\tO\nto\tO\nfix\tO\nthe\tO\ncomputer\tO\nproblem\tO\n.\tO\n\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tO\n,\tB-aspectTerm\nscreen\tO\nall\tO\ndark\tO\n,\tO\npower\tO\nlight\tB-aspectTerm\nsteady\tO\n,\tO\nhard\tO\ndrive\tB-aspectTerm\nlight\tI-aspectTerm\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tO\n\nStill\tO\npretty\tO\npricey\tO\n,\tO\nbut\tO\nI\tO\n've\tO\nbeen\tO\nputting\tO\noff\tO\nmoney\tO\nfor\tO\na\tO\nwhile\tO\nas\tO\na\tO\nlittle\tO\nMacbook\tO\nFund\tO\n,\tO\nand\tO\nfinally\tO\ngot\tO\nto\tO\nuse\tO\nit\tO\n.\tO\n\nI\tO\ntook\tO\nit\tO\nback\tO\nfor\tO\nan\tO\nAsus\tO\nand\tO\nsame\tO\nthing-\tO\nblue\tO\nscreen\tO\nwhich\tO\nrequired\tO\nme\tO\nto\tO\nremove\tO\nthe\tO\nbattery\tB-aspectTerm\nto\tO\nreset\tO\n.\tO\n\nIn\tO\nthe\tO\nshop\tO\n,\tO\nthese\tO\nMacBooks\tO\nare\tO\nencased\tO\nin\tO\na\tO\nsoft\tO\nrubber\tB-aspectTerm\nenclosure\tI-aspectTerm\n-\tO\nso\tO\nyou\tO\nwill\tO\nnever\tO\nknow\tO\nabout\tO\nthe\tO\nrazor\tO\nedge\tB-aspectTerm\nuntil\tO\nyou\tO\nbuy\tO\nit\tO\n,\tO\nget\tO\nit\tO\nhome\tO\n,\tO\nbreak\tO\nthe\tO\nseal\tO\nand\tO\nuse\tO\nit\tO\n(\tO\nvery\tO\nclever\tO\ncon\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\ngestures\tI-aspectTerm\nand\tO\nlarge\tO\ntracking\tB-aspectTerm\narea\tI-aspectTerm\nmake\tO\nhaving\tO\nan\tO\nexternal\tB-aspectTerm\nmouse\tI-aspectTerm\nunnecessary\tO\n(\tO\nunless\tO\nyou\tO\n're\tO\ngaming\tB-aspectTerm\n)\tO\n.\tO\n\nPlus\tO\nit\tO\nis\tO\nsmall\tO\nand\tO\nreasonably\tO\nlight\tO\nso\tO\nI\tO\ncan\tO\ntake\tO\nit\tO\nwith\tO\nme\tO\nto\tO\nand\tO\nfrom\tO\nwork\tO\n.\tO\n\nI\tO\nHATE\tO\nthis\tO\none\tO\n.\tO\n\nThey\tO\nwere\tO\ntotally\tO\nunconcerned\tO\nthat\tO\nthe\tO\ncomputer\tO\nwas\tO\nnot\tO\ncorrectly\tO\nrepaired\tO\nin\tO\nthe\tO\nfirst\tO\nplace\tO\n.\tO\n\nToshiba\tO\ndoes\tO\nnot\tO\nsend\tO\nany\tO\none\tO\nout\tO\nunless\tO\nyou\tO\nhave\tO\npaid\tO\nextra\tO\nto\tO\nhave\tO\nthe\tO\non\tO\nsite\tO\nrepair\tO\ndone\tO\n.\tO\n\nOh\tO\n,\tO\nboy\tO\n!\tO\n\nBut\tO\nwhile\tO\nthis\tO\nis\tO\none\tO\nbig\tO\nadvantage\tO\n(\tO\nas\tO\nyou\tO\nmay\tO\nknow\tO\nfrom\tO\nthe\tO\ncompany\tO\ns\tO\nrecent\tO\ncommercials\tO\n)\tO\nthere\tO\nare\tO\nother\tO\nthings\tO\nto\tO\nconsider\tO\nbefore\tO\ngoing\tO\nwith\tO\nApple\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nway\tO\nthe\tO\nentire\tO\nsuite\tB-aspectTerm\nof\tI-aspectTerm\nsoftware\tI-aspectTerm\nworks\tO\ntogether\tO\n.\tO\n\nThe\tO\nspeed\tB-aspectTerm\nis\tO\nincredible\tO\nand\tO\nI\tO\nam\tO\nmore\tO\nthan\tO\nsatisfied\tO\n.\tO\n\non\tO\nthe\tO\nbright\tO\nside\tO\nat\tO\nleast\tO\nI\tO\nwas\tO\nn't\tO\nwithout\tO\nmy\tO\nlaptop\tO\nfor\tO\nlong\tO\nthis\tO\ntime\tO\n!\tO\n\nThis\tO\nlaptop\tO\nmeets\tO\nevery\tO\nexpectation\tO\nand\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nis\tO\ngreat\tO\n!\tO\n\nThat\tO\n's\tO\nhow\tO\nfrustrating\tO\nit\tO\nwas\tO\n.\tO\n\nI\tO\ncan\tO\nbarely\tO\nuse\tO\nany\tO\nusb\tB-aspectTerm\ndevices\tI-aspectTerm\nbecause\tO\nthey\tO\nwill\tO\nnot\tO\nstay\tO\nconnected\tO\nproperly\tO\n.\tO\n\nThe\tO\none\tO\ndown\tO\nside\tO\nto\tO\nit\tO\nis\tO\nthat\tO\nwhen\tO\nI\tO\nplay\tO\na\tO\ncertin\tO\ngame\tO\non\tO\nhere\tO\n,\tO\nit\tO\ntends\tO\nto\tO\nfreeze\tO\nup\tO\nsometimes\tO\n,\tO\nbut\tO\nthat\tO\ns\tO\nthe\tO\nonly\tO\nbad\tO\nthing\tO\nabout\tO\nthis\tO\ncomputer\tO\n.\tO\n\n-No\tO\nbacklit\tO\nkeyboard\tB-aspectTerm\n,\tO\nbut\tO\nnot\tO\nan\tO\nissue\tO\nfor\tO\nme\tO\n.\tO\n\nWhen\tO\nI\tO\nfinally\tO\nhad\tO\neverything\tO\nrunning\tO\nwith\tO\nall\tO\nmy\tO\nsoftware\tB-aspectTerm\ninstalled\tO\nI\tO\nplugged\tO\nin\tO\nmy\tO\ndroid\tO\nto\tO\nrecharge\tO\nand\tO\nthe\tO\nsystem\tB-aspectTerm\ncrashed\tO\n.\tO\n\nI\tO\nca\tO\nn't\tO\neven\tO\nturn\tO\nit\tO\noff\tO\n.\tO\n\nOne\tO\nsuggestion\tO\nI\tO\ndo\tO\nhave\tO\n,\tO\nis\tO\nto\tO\nnot\tO\nbother\tO\ngetting\tO\nMicrosoft\tB-aspectTerm\noffice\tI-aspectTerm\nfor\tI-aspectTerm\nthe\tI-aspectTerm\nmac\tI-aspectTerm\nexpecting\tO\nit\tO\nwill\tO\nwork\tO\njust\tO\nlike\tO\nyou\tO\nknew\tO\nit\tO\nto\tO\non\tO\na\tO\nPC\tO\n.\tO\n\nPairing\tO\nit\tO\nwith\tO\nan\tO\niPhone\tO\nis\tO\na\tO\npure\tO\npleasure\tO\n-\tO\ntalk\tO\nabout\tO\npainless\tO\nsyncing\tB-aspectTerm\n-\tO\nused\tO\nto\tO\ntake\tO\nme\tO\nforever\tO\n-\tO\nnow\tO\nit\tO\n's\tO\na\tO\nsnap\tO\n.\tO\n\nI\tO\nshopped\tO\naround\tO\nbefore\tO\nbuying\tO\n.\tO\n\nI\tO\nalso\tO\ngot\tO\nthe\tO\nadded\tO\nbonus\tO\nof\tO\na\tO\n30\tB-aspectTerm\n\"\tI-aspectTerm\nHD\tI-aspectTerm\nMonitor\tI-aspectTerm\n,\tO\nwhich\tO\nreally\tO\nhelps\tO\nto\tO\nextend\tO\nmy\tO\nscreen\tB-aspectTerm\nand\tO\nkeep\tO\nmy\tO\neyes\tO\nfresh\tO\n!\tO\n\nWould\tO\ndo\tO\nbusiness\tO\nagain\tO\n.\tO\n\nThe\tO\nmachine\tO\nis\tO\nslow\tO\nto\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nand\tO\noccasionally\tO\ncrashes\tO\ncompletely\tO\n.\tO\n\nAfter\tO\npaying\tO\nseveral\tO\nhundred\tO\ndollars\tO\nfor\tO\nthis\tO\nservice\tB-aspectTerm\n,\tO\nit\tO\nis\tO\nfrustrating\tO\nthat\tO\nyou\tO\ncan\tO\nnot\tO\nget\tO\nhelp\tO\nafter\tO\nhours\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nthe\tO\nluxury\tO\n(\tO\nsarcasm\tO\n)\tO\nof\tO\nowning\tO\n2\tO\nof\tO\nthese\tO\nlaptops\tO\n.\tO\n\nWhat\tO\na\tO\nwaste\tO\n.\tO\n\nIt\tO\nwas\tO\na\tO\ntotal\tO\nDhell\tO\nexperience\tO\nthat\tO\nI\tO\nwill\tO\nnever\tO\nrepeat\tO\n.\tO\n\nThere\tO\nare\tO\na\tO\nfew\tO\nflaws\tO\nas\tO\nwell\tO\nthat\tO\nI\tO\nnoticed\tO\n.\tO\n\nCompletely\tO\nworth\tO\nevery\tO\nsingle\tO\npenny\tO\ndime\tO\nand\tO\nnickel\tO\n.\tO\n\nI\tO\ntried\tO\nto\tO\nupgrade\tO\nit\tO\nto\tO\na\tO\nnewer\tO\nversion\tO\na\tO\ncouple\tO\nof\tO\nmonths\tO\nago\tO\nand\tO\nI\tO\nstill\tO\nhave\tO\nthe\tO\nsame\tO\nproblem\tO\n.\tO\n\nI\tO\ndid\tO\nhave\tO\nto\tO\nreplace\tO\nthe\tO\nbattery\tB-aspectTerm\nonce\tO\n,\tO\nbut\tO\nthat\tO\nwas\tO\nonly\tO\na\tO\ncouple\tO\nmonths\tO\nago\tO\nand\tO\nit\tO\n's\tO\nbeen\tO\nworking\tO\nperfect\tO\never\tO\nsince\tO\n.\tO\n\n:)\tO\nIn\tO\nthe\tO\npast\tO\nfour\tO\nyears\tO\nI\tO\n've\tO\nhad\tO\nit\tO\nI\tO\nhave\tO\nnever\tO\nonce\tO\ngotten\tO\na\tO\nvirus\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nand\tO\nthe\tO\npreloaded\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nThey\tO\nwere\tO\ngreat\tO\nin\tO\nhandling\tO\nthis\tO\nproblem\tO\n,\tO\nand\tO\nI\tO\n'm\tO\nlooking\tO\nforward\tO\nin\tO\npurchasing\tO\nadditonal\tO\nproducts\tO\nfrom\tO\nthem\tO\nin\tO\nthe\tO\nfuture\tO\n.\tO\n\nI\tO\n've\tO\ntried\tO\ngoing\tO\nback\tO\nto\tO\nXL\tO\nbut\tO\nthere\tO\nstill\tO\nproblems\tO\n.\tO\n\nThe\tO\nbest\tO\nthing\tO\nabout\tO\nthis\tO\nlaptop\tO\nis\tO\nthe\tO\nprice\tB-aspectTerm\nalong\tO\nwith\tO\nsome\tO\nof\tO\nthe\tO\nnewer\tO\nfeatures\tB-aspectTerm\n.\tO\n\nAfter\tO\nnumerous\tO\nattempts\tO\nof\tO\ntrying\tO\n(\tO\nincluding\tO\nsetting\tO\nthe\tO\nclock\tB-aspectTerm\nin\tI-aspectTerm\nBIOS\tI-aspectTerm\nsetup\tI-aspectTerm\ndirectly\tO\n)\tO\n,\tO\nI\tO\ngave\tO\nup(I\tO\nam\tO\na\tO\ntechie\tO\n)\tO\n.\tO\n\nYOU\tO\nWILL\tO\nNOT\tO\nBE\tO\nABLE\tO\nTO\tO\nTALK\tO\nTO\tO\nAN\tO\nAMERICAN\tO\nWARRANTY\tB-aspectTerm\nSERVICE\tI-aspectTerm\nIS\tO\nOUT\tO\nOF\tO\nCOUNTRY\tO\n.\tO\n\nBut\tO\nit\tO\nmay\tO\nbe\tO\npotentially\tO\nhundreds\tO\nor\tO\nthousands\tO\nin\tO\nthe\tO\nnear\tO\nfuture\tO\n.\tO\n\nHas\tO\nmet\tO\nor\tO\nexceeded\tO\nmy\tO\nneeds\tO\nfor\tO\na\tO\ncompact\tO\ntravel\tO\ndevice\tO\n.\tO\n\nbut\tO\nnow\tO\ni\tO\nhave\tO\nrealized\tO\nits\tO\na\tO\nproblem\tO\nwith\tO\nthis\tO\nbrand\tB-aspectTerm\n.\tO\n\nIt\tO\ncan\tO\nnot\tO\nsave\tO\nthe\tO\ncorrect\tO\ndate\tO\nand\tO\ntime\tO\nI\tO\nset\tO\n.\tO\n\nI\tO\nsent\tO\nit\tO\nback\tO\nto\tO\nToshiba\tO\ntwice\tO\nthey\tO\ncovered\tO\nit\tO\nunder\tO\nthe\tO\nwarranty\tB-aspectTerm\n.\tO\n\nAnd\tO\nthis\tO\nis\tO\nn't\tO\njust\tO\nmy\tO\none\tO\nexperine\tO\n.\tO\n\nThey\tO\nsent\tO\nme\tO\na\tO\nreplacement\tO\npart\tO\nand\tO\nwithout\tO\ninforming\tO\nme\tO\nare\tO\nrequiring\tO\nthat\tO\nI\tO\nreturn\tO\nit\tO\nwithin\tO\n15\tO\ndays\tO\nor\tO\ncontact\tO\nthem\tO\nand\tO\nlet\tO\nthem\tO\nknow\tO\nthe\tO\nbroken\tO\npart\tO\nwill\tO\nbe\tO\nreturned\tO\nlater\tO\n.\tO\n\nI\tO\nwas\tO\nlooking\tO\nfor\tO\na\tO\nmac\tO\nwhich\tO\nis\tO\nportable\tO\nand\tO\nhas\tO\nall\tO\nthe\tO\nfeatures\tB-aspectTerm\nthat\tO\nI\tO\nwas\tO\nlooking\tO\nfor\tO\n.\tO\n\nI\tO\nwould\tO\nhighly\tO\nrecommend\tO\nthis\tO\none\tO\nto\tO\nmy\tO\nfriends\tO\n\nI\tO\nhonestly\tO\nlove\tO\nmy\tO\nmac\tO\n,\tO\nthat\tO\ns\tO\nwhy\tO\nI\tO\nam\tO\na\tO\nself\tO\nproclaimed\tO\nmac\tO\naddict\tO\n.\tO\n\nAnd\tO\nthese\tO\nare\tO\nsome\tO\nreasons\tO\nyou\tO\nshould\tO\nget\tO\na\tO\nmacbook\tO\npro\tO\n.\tO\n\nAlso\tO\nkinda\tO\nloud\tO\nwhen\tO\nthe\tO\nfan\tB-aspectTerm\nwas\tO\nrunning\tO\n.\tO\n\nIn\tO\ndesparation\tO\n,\tO\nI\tO\ncalled\tO\ntheir\tO\nCustomer\tB-aspectTerm\nService\tI-aspectTerm\nnumber\tI-aspectTerm\nand\tO\nwas\tO\ntold\tO\nthat\tO\nmy\tO\nwarranty\tB-aspectTerm\nhad\tO\nexpired\tO\n(\tO\n2\tO\ndays\tO\nold\tO\n)\tO\nand\tO\nthat\tO\nthe\tO\npriviledge\tO\nof\tO\ntalking\tB-aspectTerm\nto\tI-aspectTerm\na\tI-aspectTerm\ntechnician\tI-aspectTerm\nwould\tO\ncost\tO\nme\tO\n(\tO\n\"\tO\nhave\tO\nyour\tO\ncredit\tO\ncard\tO\nready\tO\n\"\tO\n)\tO\n.\tO\n\nI\tO\npurchased\tO\nthis\tO\nlaptop\tO\nwhile\tO\non\tO\na\tO\nbusiness\tO\ntrip\tO\nto\tO\nkeep\tO\nup\tO\nwith\tO\nmy\tO\nemail\tO\n.\tO\n\nThere\tO\nalso\tO\nseemed\tO\nto\tO\nbe\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\nhard\tB-aspectTerm\ndisc\tI-aspectTerm\nas\tO\ncertain\tO\ntimes\tO\nwindows\tB-aspectTerm\nloads\tO\nbut\tO\nclaims\tO\nto\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\nfind\tO\nany\tO\ndrivers\tB-aspectTerm\nor\tO\nfiles\tO\n.\tO\n\nDrivers\tB-aspectTerm\nupdated\tO\nok\tO\nbut\tO\nthe\tO\nBIOS\tB-aspectTerm\nupdate\tI-aspectTerm\nfroze\tO\nthe\tO\nsystem\tB-aspectTerm\nup\tO\nand\tO\nthe\tO\ncomputer\tO\nshut\tO\ndown\tO\n.\tO\n\n-they\tO\nlost\tO\nmy\tO\nlaptop\tO\nfor\tO\na\tO\nmonth\tO\n\nSpent\tO\n2\tO\nhours\tO\non\tO\nphone\tO\nwith\tO\nHP\tB-aspectTerm\nTechnical\tI-aspectTerm\nSupport\tI-aspectTerm\n.\tO\n\nThis\tO\nis\tO\nmy\tO\nsecond\tO\nlaptop\tO\n,\tO\nand\tO\nit\tO\nis\tO\nhead\tO\nand\tO\nshoulders\tO\nabove\tO\nmy\tO\nfirst\tO\n.\tO\n\nat\tO\nfirst\tO\n!\tO\n\nSpeaking\tO\nof\tO\nthe\tO\nbrowser\tB-aspectTerm\n,\tO\nit\tO\ntoo\tO\nhas\tO\nproblems\tO\n.\tO\n\nI\tO\nthink\tO\njust\tO\ngoing\tO\nfrom\tO\nPC\tO\nto\tO\nMac\tO\nhas\tO\ngotten\tO\nme\tO\ntotally\tO\nspoiled\tO\nand\tO\nI\tO\nca\tO\nn't\tO\nimagine\tO\never\tO\ngoing\tO\nback\tO\n.\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\nis\tO\ntoo\tO\nslick\tO\n.\tO\n\nNightly\tO\nmy\tO\ncomputer\tO\ndefrags\tO\nitself\tO\nand\tO\nruns\tO\na\tO\nvirus\tB-aspectTerm\nscan\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nlike\tO\n9\tB-aspectTerm\npunds\tI-aspectTerm\n,\tO\nbut\tO\nif\tO\nyou\tO\ncan\tO\nlook\tO\npast\tO\nit\tO\n,\tO\nit\tO\n's\tO\nGREAT\tO\n!\tO\n\nIt\tO\n's\tO\njust\tO\nas\tO\nfast\tO\nwith\tO\none\tO\nprogram\tB-aspectTerm\nopen\tO\nas\tO\nit\tO\nis\tO\nwith\tO\nsixteen\tO\nopen\tO\n.\tO\n\nStill\tO\nunder\tO\nwarrenty\tB-aspectTerm\nso\tO\ncalled\tO\nToshiba\tO\n,\tO\nno\tO\nhelp\tO\nat\tO\nall\tO\n.\tO\n\nI\tO\nwas\tO\nhappy\tO\nwith\tO\nMy\tO\npurchase\tO\nof\tO\na\tO\nToshiba\tO\nSatellite\tO\nL305D\tO\n-\tO\nS5934\tO\nlaptop\tO\nuntil\tO\nit\tO\ncame\tO\ntime\tO\nto\tO\nhave\tO\nit\tO\nrepaired\tO\nunder\tO\nthe\tO\nToshiba\tB-aspectTerm\nWarranty\tI-aspectTerm\n.\tO\n\nI\tO\nLOVE\tO\nIT\tO\n!\tO\n\nAmazing\tO\nQuality\tB-aspectTerm\n!\tO\n\nThe\tO\nfact\tO\nthat\tO\nyou\tO\ncan\tO\nspend\tO\nover\tO\n$\tO\n100\tO\non\tO\njust\tO\na\tO\nwebcam\tB-aspectTerm\nunderscores\tO\nthe\tO\nvalue\tB-aspectTerm\nof\tO\nthis\tO\nmachine\tO\n.\tO\n\nI\tO\nmainly\tO\nuse\tO\nit\tO\nfor\tO\nemail\tO\n,\tO\ninternet\tB-aspectTerm\n,\tO\nand\tO\nmanaging\tB-aspectTerm\npersonal\tI-aspectTerm\nfiles\tI-aspectTerm\n(\tO\npics\tO\n,\tO\nvids\tO\n,\tO\netc\tO\n.\tO\n)\tO\n.\tO\n\nA\tO\nmonth\tO\nor\tO\nso\tO\nago\tO\n,\tO\nthe\tO\nfreaking\tO\nmotherboard\tB-aspectTerm\njust\tO\ndied\tO\n.\tO\n\nThe\tO\nsystem\tB-aspectTerm\nit\tO\ncomes\tO\nwith\tO\ndoes\tO\nnot\tO\nwork\tO\nproperly\tO\n,\tO\nso\tO\nwhen\tO\ntrying\tO\nto\tO\nfix\tO\nthe\tO\nproblems\tO\nwith\tO\nit\tO\nit\tO\nstarted\tO\nnot\tO\nworking\tO\nat\tO\nall\tO\n.\tO\n\nThen\tO\nafter\tO\n4\tO\nor\tO\nso\tO\nmonths\tO\nthe\tO\ncharger\tB-aspectTerm\nstopped\tO\nworking\tO\nso\tO\nI\tO\nwas\tO\nforced\tO\nto\tO\ngo\tO\nout\tO\nand\tO\nbuy\tO\nnew\tO\nhardware\tB-aspectTerm\njust\tO\nto\tO\nkeep\tO\nthis\tO\ncomputer\tO\nrunning\tO\n.\tO\n\nI\tO\ntook\tO\nit\tO\nback\tO\nto\tO\nBest\tO\nBuy\tO\nwhere\tO\nthey\tO\nwere\tO\nso\tO\nhelpful\tO\nand\tO\nimmediately\tO\ngave\tO\nme\tO\na\tO\nnew\tO\none\tO\n.\tO\n\nIf\tO\nyou\tO\nhad\tO\nPC\tO\nfor\tO\nfour\tO\nyears\tO\nI\tO\ncan\tO\nalmost\tO\ngaurentee\tO\nthat\tO\nsomething\tO\nwould\tO\nof\tO\ngone\tO\nwrong\tO\nby\tO\nnow\tO\n,\tO\nmaybe\tO\neven\tO\nforcing\tO\nyou\tO\nto\tO\nreplace\tO\nyour\tO\nentire\tO\ncomputer\tO\n.\tO\n\n*\tO\n2\tO\nweeks\tO\nafter\tO\ngiving\tO\nthe\tO\ncomputer\tO\nfor\tO\nrepair*-Called\tO\nheadquarters\tO\n,\tO\nthey\tO\nreport\tO\nthat\tO\nthey\tO\nhave\tO\nnot\tO\nlooked\tO\nat\tO\nit\tO\nyet\tO\nbut\tO\nit\tO\nis\tO\n\"\tO\non\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nstack\tO\n\"\tO\n.\tO\n\nThis\tO\nmachine\tO\ndelivers\tO\n.\tO\n\nThen\tO\n2\tO\nof\tO\nmy\tO\nnephews\tO\nwere\tO\ngoing\tO\ninto\tO\nmusic\tO\nand\tO\nboth\tO\nfell\tO\nin\tO\nlove\tO\nwith\tO\nthe\tO\nMacBook\tO\nPro\tO\n.\tO\n\nI\tO\ncomplain\tO\nagain\tO\n...\tO\n\nThis\tO\nlaptop\tO\nis\tO\ninsane\tO\n!\tO\n!\tO\n!\tO\n\nIf\tO\na\tO\nwebsite\tO\never\tO\nfreezes\tO\n(\tO\nwhich\tO\nis\tO\nrare\tO\n)\tO\n,\tO\nits\tO\nreally\tO\neasy\tO\nto\tO\nforce\tB-aspectTerm\nquit\tI-aspectTerm\n.\tO\n\nIt\tO\ndoes\tO\nrun\tO\na\tO\nlittle\tO\nwarm\tO\nbut\tO\nthat\tO\nis\tO\na\tO\nnegligible\tO\nconcern\tO\n.\tO\n\nIt\tO\nrarely\tO\nworks\tB-aspectTerm\nand\tO\nwhen\tO\nit\tO\ndoes\tO\nit\tO\n's\tO\nincredibly\tO\nslow\tO\n.\tO\n\nI\tO\nalso\tO\nenjoy\tO\nthe\tO\nfact\tO\nthat\tO\nmy\tO\nMacBook\tO\nPro\tO\nlaptop\tO\nallows\tO\nme\tO\nto\tO\nrun\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\non\tO\nit\tO\nby\tO\nusing\tO\nthe\tO\nVMWare\tB-aspectTerm\nprogram\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tO\nto\tO\nnavigate\tB-aspectTerm\nthrough\tO\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n,\tO\nto\tO\nfind\tB-aspectTerm\nfiles\tI-aspectTerm\n,\tO\nand\tO\nit\tO\nruns\tB-aspectTerm\na\tO\nlot\tO\nfaster\tO\n!\tO\n\nPurchased\tO\na\tO\nToshiba\tO\nLap\tO\ntop\tO\nit\tO\nworked\tO\ngood\tO\nuntil\tO\njust\tO\nafter\tO\nthe\tO\nwarrenty\tB-aspectTerm\nwent\tO\nout\tO\n.\tO\n\nI\tO\nalways\tO\nswore\tO\nby\tO\nPCs\tO\nand\tO\nwould\tO\nnever\tO\nconsider\tO\na\tO\nMAC\tO\n.\tO\n\nwhat\tO\nan\tO\nelegant\tO\n,\tO\nwonderful\tO\nmachine\tO\n.\tO\n\nThis\tO\nis\tO\nnow\tO\nmy\tO\n3rd\tO\nMacBook\tO\nPro\tO\nand\tO\nI\tO\nreally\tO\nhonestly\tO\nlove\tO\nit\tO\n!\tO\n\nfor\tO\n2\tO\nmonths\tO\n.\tO\n\nI\tO\nwanted\tO\nto\tO\npurchase\tO\nthe\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\nand\tO\nthey\tO\nrefused\tO\n,\tO\nbecause\tO\nthey\tO\nknew\tO\nit\tO\nwas\tO\ntrouble\tO\n.\tO\n\nDo\tO\nyou\tO\never\tO\nthink\tO\nHP\tO\nwould\tO\ndo\tO\nthat\tO\n?\tO\nNEVER\tO\n!\tO\n\nWe\tO\nupgraded\tO\nthe\tO\nmemory\tB-aspectTerm\nto\tO\nfour\tO\ngigabytes\tO\nin\tO\norder\tO\nto\tO\ntake\tO\nadvantage\tO\nof\tO\nthe\tO\nperformace\tB-aspectTerm\nincrease\tO\nin\tO\nspeed\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nnot\tO\nlike\tO\nI\tO\nhave\tO\nused\tO\nfor\tO\nhalf\tO\na\tO\nyear\tO\nand\tO\nthen\tO\ncomplained\tO\nabout\tO\nit\tO\n.\tO\n\nStill\tO\ntrying\tO\nto\tO\nlearn\tO\nhow\tO\nto\tO\nuse\tO\nit\tO\n.\tO\n\nThe\tO\nreality\tO\nwas\tO\n,\tO\nit\tO\nheated\tO\nup\tO\nvery\tO\nquickly\tO\n,\tO\nand\tO\ntook\tO\nway\tO\ntoo\tO\nlong\tO\nto\tO\ndo\tO\nsimple\tO\nthings\tO\n,\tO\nlike\tO\nopening\tB-aspectTerm\nmy\tI-aspectTerm\nDocuments\tI-aspectTerm\nfolder\tI-aspectTerm\n.\tO\n\nI\tO\nbought\tO\nthe\tO\nnetbook\tO\nbecause\tO\nit\tO\nwas\tO\nsmaller\tO\nand\tO\nlighter\tO\nfor\tO\nme\tO\nto\tO\ncarry\tO\naround\tO\n.\tO\n\nThe\tO\nGenius\tO\nat\tO\nthe\tO\nApple\tO\nstore\tO\nadvised\tO\nme\tO\nthat\tO\nthere\tO\nwas\tO\nnothing\tO\nabout\tO\nmy\tO\nuse\tO\nof\tO\nthe\tO\ncomputer\tO\nthat\tO\ncaused\tO\nthis\tO\nfailure\tO\n.\tO\n\nWe\tO\n'll\tO\nsave\tO\nour\tO\nmoney\tO\nto\tO\nreplace\tO\nit\tO\nwith\tO\na\tO\nMac\tO\nagain\tO\n!\tO\n\nThank\tO\nyou\tO\nfor\tO\nyour\tO\ngreat\tO\nproduct\tO\n!\tO\n\nthis\tO\ncompany\tO\ntruely\tO\ndoes\tO\nmake\tO\nhorrible\tO\nproducts\tO\nand\tO\ndoes\tO\nnt\tO\nseem\tO\nto\tO\nbecause\tO\nthey\tO\nare\tO\ncertain\tO\nthings\tO\nlike\tO\nthis\tO\n\"\tO\nnever\tO\n\"\tO\nhappen\tO\n...\tO\n\nI\tO\nhad\tO\nalways\tO\nused\tO\nPCs\tO\nand\tO\nbeen\tO\nconstantly\tO\nfrustrated\tO\nby\tO\nthe\tO\ncrashing\tO\nand\tO\nthe\tO\npoorly\tO\ndesigned\tO\noperating\tB-aspectTerm\nsystems\tI-aspectTerm\nthat\tO\nwere\tO\nnever\tO\nvery\tO\nintuitive\tO\n.\tO\n\nSorry\tO\nToshiba\tO\n,\tO\nbut\tO\n1st\tO\nimpressions\tO\ndo\tO\ncount\tO\nfor\tO\nsomething\tO\n.\tO\n\nThen\tO\n,\tO\nwithin\tO\n5\tO\nmonths\tO\n,\tO\nthe\tO\ncharger\tB-aspectTerm\ncrapped\tO\nout\tO\non\tO\nme\tO\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\nhave\tO\na\tO\niphone\tO\nor\tO\nipod\tO\ntouch\tO\nyou\tO\ncan\tO\nconnect\tO\nand\tO\ndownload\tO\nsongs\tO\nto\tO\nit\tO\nat\tO\nhigh\tO\nspeed\tB-aspectTerm\n.\tO\n\nOverall\tO\nthis\tO\nlaptop\tO\nis\tO\ngreat\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nglass\tB-aspectTerm\ntouchpad\tI-aspectTerm\n.\tO\n\nI\tO\ncontinued\tO\nto\tO\ntake\tO\nthe\tO\ncomputer\tO\nin\tO\nAGAIN\tO\nand\tO\nthey\tO\nreplaced\tO\nthe\tO\nhard\tO\ndrive\tB-aspectTerm\nand\tI-aspectTerm\nmother\tO\nboard\tB-aspectTerm\nyet\tI-aspectTerm\nagain\tO\n.\tO\n\nI\tO\nam\tO\nusing\tO\nthe\tO\nexternal\tB-aspectTerm\nspeaker-\tI-aspectTerm\nsound\tB-aspectTerm\nis\tO\ngood\tO\n.\tO\n\nThe\tO\nApple\tO\nMC371LL\tO\n/\tO\nA\tO\n2.4Ghz\tO\n15.4-inch\tO\nMacBook\tO\nPro\tO\nNotebook\tO\nis\tO\na\tO\nhorrible\tO\nwaste\tO\nof\tO\nmoney\tO\n.\tO\n\nOk\tO\n,\tO\nthis\tO\nis\tO\nprobably\tO\nthe\tO\nbest\tO\nlaptop\tO\nseries\tO\never\tO\ndevised\tO\nby\tO\nApple\tO\n.\tO\n\nAs\tO\nof\tO\na\tO\ncouple\tO\nweeks\tO\nago\tO\nthe\tO\nmiddle\tO\nportion\tO\nof\tO\nthe\tO\nlaptop\tO\nfrom\tO\ntop\tO\nto\tO\nbottom,,,about\tO\n4\tO\ninches\tO\nacross\tO\nis\tO\nhardly\tO\nvisible\tO\n.\tO\n\nstill\tO\ntesting\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nas\tO\ni\tO\nthought\tO\nit\tO\nwould\tO\nbe\tO\nbetter\tO\n,\tO\nbut\tO\nam\tO\nvery\tO\nhappy\tO\nwith\tO\nthe\tO\nupgrade\tO\n.\tO\n\nThen\tO\nHP\tO\nsends\tO\nit\tO\nback\tO\nto\tO\nme\tO\nwith\tO\nthe\tO\nhardware\tB-aspectTerm\nscrewed\tO\nup\tO\n,\tO\nnot\tO\nable\tO\nto\tO\nconnect\tO\n.\tO\n\nI\tO\njust\tO\nhope\tO\nthe\tO\nreputation\tO\nthat\tO\nToshiba\tO\nhas\tO\nis\tO\ntrue\tO\nand\tO\nI\tO\nwo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tO\nabout\tO\na\tO\ncrash\tO\n.\tO\n\nOh\tO\nyeah\tO\n,\tO\ndo\tO\nn't\tO\nforget\tO\nthe\tO\nexpensive\tO\nshipping\tB-aspectTerm\nto\tO\nand\tO\nfrom\tO\nHP\tO\n.\tO\n\nI\tO\nwould\tO\nrecommend\tO\nanyone\tO\nto\tO\nbuy\tO\nfrom\tO\npcconnection\tO\nexpress\tO\n.\tO\n\nGood\tO\nluck\tO\n.\tO\n\nEverything\tO\nis\tO\nso\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nMac\tB-aspectTerm\nsoftware\tI-aspectTerm\nis\tO\njust\tO\nso\tO\nmuch\tO\nsimpler\tO\nthan\tO\nMicrosoft\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nMy\tO\nfavorite\tO\nby\tO\nfar\tO\n,\tO\nalthough\tO\nthe\tO\nmost\tO\nexpensive\tO\n,\tO\nwas\tO\nmy\tO\nSony\tO\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\ndo\tO\na\tO\nlot\tO\nof\tO\nwriting\tO\n,\tO\nediting\tB-aspectTerm\nis\tO\na\tO\nproblem\tO\nsince\tO\nthere\tO\nis\tO\nno\tO\nforward\tO\ndelete\tO\nkey\tB-aspectTerm\n.\tI-aspectTerm\n\nAlso\tO\nI\tO\ntyped\tO\nfaster\tO\nthen\tO\nthen\tO\nletters\tO\nwould\tO\nshow\tO\nand\tO\nit\tO\ngot\tO\nto\tO\nbe\tO\nrealy\tO\nannoying\tO\n.\tO\n\nAs\tO\nan\tO\nowner\tO\nof\tO\na\tO\nToshiba\tO\nSatalite\tO\nlaptop\tO\ncomputer\tO\nthings\tO\nyou\tO\nshould\tO\nknow\tO\nbefore\tO\nyou\tO\nbuy\tO\n.\tO\n\nIts\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\nand\tO\nthe\tO\ntop\tO\nservice\tB-aspectTerm\nfrom\tO\nApple-\tO\nbe\tO\nit\tO\ntheir\tO\nphone\tB-aspectTerm\nassistance\tI-aspectTerm\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tB-aspectTerm\nbar-\tI-aspectTerm\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\nand\tO\nword\tB-aspectTerm\nediting\tI-aspectTerm\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tB-aspectTerm\nand\tO\nmovie\tB-aspectTerm\nplaying\tI-aspectTerm\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nI\tO\nshipped\tO\nout\tO\non\tO\nSaturday\tO\n,\tO\nJuly\tO\n17\tO\n.\tO\n\nI\tO\nbought\tO\nit\tO\nfor\tO\nreally\tO\ncheap\tO\nalso\tO\nand\tO\nit\tO\n's\tO\nAMAZING\tO\n.\tO\n\nAcer\tO\nhas\tO\nset\tO\nme\tO\nup\tO\nwith\tO\nFREE\tO\nrecovery\tB-aspectTerm\ndiscs\tI-aspectTerm\n,\tO\nwhen\tO\nthey\tO\nare\tO\navailable\tO\nsince\tO\nI\tO\nasked\tO\n.\tO\n\nI\tO\nalso\tO\npurchased\tO\nOffice\tB-aspectTerm\nMax\tI-aspectTerm\n's\tI-aspectTerm\n\"\tI-aspectTerm\nMax\tI-aspectTerm\nAssurance\tI-aspectTerm\n\"\tI-aspectTerm\nwith\tO\nthe\tO\n\"\tO\nno\tO\nlemon\tO\n\"\tO\nclause\tO\n.\tO\n\nIf\tO\nyou\tO\nfind\tO\nyourself\tO\nin\tO\nthe\tO\nmarket\tO\nfor\tO\na\tO\nnew\tO\nlaptop\tO\n(\tO\nand\tO\nhave\tO\nthe\tO\nmoney\tO\n)\tO\ndo\tO\nn't\tO\nexclude\tO\nlooking\tO\nat\tO\nthe\tO\nMBPs\tO\n.\tO\n\nI\tO\neventually\tO\ndid\tO\nthe\tO\nmigration\tO\nfrom\tO\nmy\tO\niMac\tB-aspectTerm\nbackup\tI-aspectTerm\ndisc\tI-aspectTerm\nwhich\tO\nuses\tO\nUSB\tB-aspectTerm\n.\tO\n\nThose\tO\nthings\tO\nare\tO\nvery\tO\nimportant\tO\n-\tO\nvital\tO\neven\tO\n!\tO\n\n-They\tO\nsay\tO\nit\tO\nwill\tO\ntake\tO\n\"\tO\nup\tO\nto\tO\ntwo\tO\nweeks\tO\n\"\tO\n.\tO\n\nI\tO\ndid\tO\nn't\tO\nlike\tO\none\tO\nthing\tO\nabout\tO\nit\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nseems\tO\nto\tO\nbe\tO\nvery\tO\ngood\tO\n,\tO\nand\tO\nhave\tO\nhad\tO\nno\tO\nissues\tO\nwith\tO\nit\tO\n.\tO\n\nEnabling\tO\nthe\tO\nbattery\tB-aspectTerm\ntimer\tI-aspectTerm\nis\tO\nuseless\tO\n.\tO\n\nTemperatures\tB-aspectTerm\non\tO\nthe\tO\noutside\tO\nwere\tO\nalright\tO\nbut\tO\ni\tO\ndid\tO\nnot\tO\ntrack\tO\nin\tO\nCore\tB-aspectTerm\nProcessing\tI-aspectTerm\nUnit\tI-aspectTerm\ntemperatures\tI-aspectTerm\n.\tO\n\nYeah\tO\n,\tO\nto\tO\nyou\tO\n.\tO\n\nI\tO\ngot\tO\na\tO\nmac\tO\nas\tO\nmy\tO\nHS\tO\ngraduation\tO\ngift\tO\n.\tO\n\nI\tO\nhave\tO\nnow\tO\nhad\tO\nit\tO\nfor\tO\n1.5\tO\nmonths\tO\nand\tO\nlove\tO\nit\tO\n.\tO\n\nIt\tO\nturned\tO\nout\tO\nit\tO\n's\tO\nnot\tO\nreally\tO\na\tO\nproblem\tO\nto\tO\nhave\tO\na\tO\nMac\tO\n.\tO\n\nPage\tO\njust\tO\ndisapeared\tO\nafter\tO\nyou\tO\ngot\tO\nyahoo\tO\nor\tO\ndownloaded\tO\nsomething\tO\n.\tO\n\nImages\tO\ncan\tO\nbe\tO\nmulti\tO\n-\tO\nselected\tO\nand\tO\nviewed\tO\nswiftly\tO\nor\tO\nin\tO\nslideshow\tO\nmode\tO\n.\tO\n\nGoing\tO\nto\tO\nbring\tO\nit\tO\nto\tO\nservice\tB-aspectTerm\ntoday\tO\n.\tO\n\nThere\tO\nis\tO\nno\tO\nneed\tO\nto\tO\npurchase\tO\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\nfor\tI-aspectTerm\nMac\tI-aspectTerm\n,\tO\nwhich\tO\nsaves\tO\nme\tO\na\tO\nlot\tO\nof\tO\ntime\tO\nand\tO\nmoney\tO\n.\tO\n\nBut\tO\nwe\tO\nhad\tO\npaid\tO\nfor\tO\nbluetooth\tB-aspectTerm\n,\tO\nand\tO\nthere\tO\nwas\tO\nnone\tO\n.\tO\n\nSo\tO\n,\tO\nI\tO\npaid\tO\na\tO\nvisit\tO\nto\tO\nLG\tB-aspectTerm\nnotebook\tI-aspectTerm\nservice\tI-aspectTerm\ncenter\tI-aspectTerm\nat\tO\nAlexandra\tO\nRoad\tO\n,\tO\nhoping\tO\nthey\tO\ncan\tO\nmake\tO\nthe\tO\nhinge\tB-aspectTerm\ntighter\tO\n.\tO\n\nMy\tO\ndaughter\tO\nuses\tO\nit\tO\nfor\tO\ngames\tB-aspectTerm\n,\tO\nemail\tO\n,\tO\nfacebook\tO\n,\tO\npictures\tO\nand\tO\nmusic\tO\n.\tO\n\nLaptop\tO\nis\tO\nto\tO\nbe\tO\nused\tO\nlike\tO\na\tO\nNetbook\tO\n.\tO\n\nIt\tO\nis\tO\nalways\tO\nreliable\tO\n,\tO\nnever\tO\nbugged\tO\nand\tO\nresponds\tB-aspectTerm\nwell\tO\n.\tO\n\nAfter\tO\nabout\tO\na\tO\nweek\tO\nI\tO\nfinally\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nthe\tO\nmotherboard\tB-aspectTerm\nhad\tO\nfailed\tO\nand\tO\nso\tO\nthey\tO\ninstalled\tO\na\tO\nnew\tO\nmotherboard\tB-aspectTerm\n.\tO\n\nTrying\tO\nto\tO\nbalance\tO\nall\tO\nof\tO\nmy\tO\nroles\tO\nleaves\tO\nvery\tO\nlittle\tO\ntime\tO\nfor\tO\nme\tO\nto\tO\ndo\tO\nanything\tO\n,\tO\nso\tO\nI\tO\nwant\tO\nto\tO\nmanage\tO\nmy\tO\ntime\tO\nI\tO\ndo\tO\nhave\tO\nto\tO\nbe\tO\nthe\tO\nmost\tO\nefficient\tO\n.\tO\n\nIt\tO\nwas\tO\nslow\tO\n,\tO\nlocked\tO\nup\tO\n,\tO\nand\tO\nalso\tO\nhad\tO\nhardware\tB-aspectTerm\nreplaced\tO\nafter\tO\nonly\tO\n2\tO\nmonths\tO\n!\tO\n\nthey\tO\nhad\tO\nto\tO\nreplace\tO\nthe\tO\nmotherboard\tB-aspectTerm\nin\tO\nApril\tO\n\nYes\tO\n,\tO\nthe\tO\ncomputer\tO\nwas\tO\nlight\tO\nweight\tO\n,\tO\nless\tO\nexpensive\tO\nthan\tO\nthe\tO\naverage\tO\nlaptop\tO\n,\tO\nand\tO\nwas\tO\npretty\tO\nself\tO\nexplantory\tO\nin\tO\nuse\tB-aspectTerm\n.\tO\n\nAlso\tO\n,\tO\nif\tO\nyou\tO\nneed\tO\nto\tO\ntalk\tO\nto\tO\na\tO\nrepresentive\tB-aspectTerm\nat\tI-aspectTerm\nMicrosoft\tI-aspectTerm\n,\tO\nthere\tO\nis\tO\na\tO\ncharge\tO\n,\tO\nwhich\tO\nI\tO\nbelieve\tO\nis\tO\nrobbery\tO\n,\tO\nsince\tO\nyou\tO\nare\tO\ncharged\tO\nenormous\tO\namounts\tO\nfor\tO\na\tO\nvery\tO\nbadly\tO\ndesigned\tO\nsystem\tB-aspectTerm\n,\tO\nwhich\tO\nmost\tO\npeople\tO\nwould\tO\nhave\tO\nwent\tO\nwith\tO\nXP\tB-aspectTerm\nif\tO\nthey\tO\ncould\tO\n.\tO\n\nThere\tO\nis\tO\na\tO\nlittle\tO\nindent\tO\nto\tO\nhelp\tO\nopen\tO\nit\tO\n-\tO\nbut\tO\ngood\tO\nluck\tO\nwith\tO\nthat\tO\n.\tO\n\nI\tO\nlove\tO\nWIndows\tB-aspectTerm\n7\tI-aspectTerm\nwhich\tO\nis\tO\na\tO\nvast\tO\nimprovment\tO\nover\tO\nVista\tB-aspectTerm\n.\tO\n\nAlso\tO\n,\tO\nI\tO\nhave\tO\nalot\tO\nof\tO\ntrouble\tO\nwith\tO\nit\tO\ngetting\tO\nvery\tO\nhot\tO\n,\tO\nand\tO\nnot\tO\neven\tO\nsitting\tO\non\tO\nanything\tO\nto\tO\nmake\tO\nit\tO\nhot\tO\n.\tO\n\nIt\tO\nWas\tO\na\tO\ngreat\tO\ndeal\tO\nafter\tO\nall\tO\n.\tO\n\nThis\tO\nmac\tO\nis\tO\ngreat\tO\n!\tO\n\nKeyboard\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nvery\tO\nquiet\tO\nfor\tO\nall\tO\nthe\tO\ntyping\tO\nthat\tO\nI\tO\ndo\tO\n.\tO\n\nI\tO\ngrew\tO\nup\tO\nin\tO\na\tO\ndesign\tO\nfamily\tO\nso\tO\nit\tO\nonly\tO\nmade\tO\nsense\tO\n.\tO\n\nGave\tO\nphonenumber\tO\n.\tO\n\nIt\tO\nwould\tO\ntake\tO\nup\tO\ntoo\tO\nmuch\tO\ntime\tO\nto\tO\ndo\tO\nreaearch\tO\nfor\tO\nmy\tO\npapers\tO\nand\tO\nI\tO\nwould\tO\nbe\tO\nup\tO\nhours\tO\n-\tO\njust\tO\nbecause\tO\nthe\tO\ncomputer\tO\nwas\tO\ntoo\tO\nslow\tO\n.\tO\n\nOh\tO\nmy\tO\ngoodness\tO\n-\tO\nI\tO\nam\tO\nnot\tO\na\tO\nhappy\tO\ncamper\tO\n.\tO\n\nDell\tB-aspectTerm\n's\tI-aspectTerm\ncustomer\tI-aspectTerm\ndisservice\tI-aspectTerm\nis\tO\nan\tO\ninsult\tO\nto\tO\nit\tO\n's\tO\ncustomers\tO\nwho\tO\npay\tO\ngood\tO\nmoney\tO\nfor\tO\nshoddy\tO\nproducts\tO\n.\tO\n\nI\tO\n'd\tO\nrecommend\tO\nthis\tO\nlaptop\tO\nto\tO\nanyone\tO\n!\tO\n\nYet\tO\n,\tO\nHP\tO\nwo\tO\nn't\tO\ndo\tO\nanything\tO\nabout\tO\nthe\tO\nproblem\tO\n.\tO\n\ni\tO\n'm\tO\nreturning\tO\nmine\tO\n\nIt\tO\nhad\tO\na\tO\ncooling\tB-aspectTerm\nsystem\tI-aspectTerm\nmalfunction\tO\nafter\tO\n10\tO\nminutes\tO\nof\tO\ngeneral\tO\nuse\tB-aspectTerm\n,\tO\nand\tO\nwould\tO\nnot\tO\nmove\tO\npast\tO\nthis\tO\nerror\tO\n.\tO\n\nI\tO\ncan\tO\nrender\tO\nAVCHD\tO\nmovies\tO\nwith\tO\nlittle\tO\neffort\tO\n,\tO\nwhich\tO\nwas\tO\na\tO\nproblem\tO\nfor\tO\nmost\tO\npc\tO\n's\tO\nunless\tO\nyou\tO\nhad\tO\na\tO\nquad\tB-aspectTerm\ncore\tI-aspectTerm\nI7\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\na\tO\nbummer\tO\nand\tO\none\tO\nout\tO\nof\tO\nfive\tO\nis\tO\nbeing\tO\nkind\tO\n.\tO\n\nThis\tO\nis\tO\nwhat\tO\nthey\tO\ntold\tO\nme\tO\n:\tO\nIt\tO\nheats\tO\nup\tO\n,\tO\nand\tO\nthat\tO\nis\tO\nthe\tO\nreason\tO\nwe\tO\nno\tO\nlonger\tO\ncall\tO\nthem\tO\nlaptops\tO\n,\tO\nand\tO\nsimply\tO\ncategorize\tO\nthem\tO\nas\tO\nportables\tO\n.\tO\n\nAfter\tO\ntalking\tO\nit\tO\nover\tO\nwith\tO\nthe\tO\nvery\tO\nknowledgeable\tO\nsales\tB-aspectTerm\nassociate\tI-aspectTerm\n,\tO\nI\tO\nchose\tO\nthe\tO\nMacBook\tO\nPro\tO\nover\tO\nthe\tO\nwhite\tO\nMacBook\tO\n.\tO\n\nIf\tO\nyou\tO\nreally\tO\nwant\tO\na\tO\nbang\tO\n-\tO\nup\tO\nsystem\tB-aspectTerm\nand\tO\ndo\tO\nn't\tO\nneed\tO\nto\tO\nrun\tO\nWindows\tB-aspectTerm\napplications\tI-aspectTerm\n,\tO\ngo\tO\nwith\tO\nan\tO\nApple\tO\n;\tO\n\nYou\tO\nwo\tO\nn't\tO\nhave\tO\nto\tO\nspend\tO\ngobs\tO\nof\tO\nmoney\tO\non\tO\nsome\tO\ninefficient\tO\nvirus\tB-aspectTerm\nprogram\tI-aspectTerm\nthat\tO\nneeds\tO\nto\tO\nbe\tO\nupdated\tO\nevery\tO\nmonth\tO\nand\tO\nthat\tO\nconstantly\tO\ndrains\tO\nyour\tO\nwallet\tO\n.\tO\n\nThis\tO\nlaptop\tO\nis\tO\nfast\tO\nand\tO\nyou\tO\nwill\tO\nliterally\tO\nlearn\tO\nall\tO\nyou\tO\ncan\tO\ndo\tO\nwith\tO\nthis\tO\ndynamo\tO\nby\tO\njust\tO\nwatching\tO\nthe\tO\nonline\tO\ntutorials\tO\n.\tO\n\nOne\tO\nof\tO\nthem\tO\nseems\tO\nto\tO\nhave\tO\nworked\tO\n.\tO\n\nWhich\tO\nI\tO\nstill\tO\nuse\tO\nand\tO\nhave\tO\nhooked\tO\nup\tO\nto\tO\nmy\tO\nTV\tO\n.\tO\n\nThe\tO\nproblem\tO\nI\tO\nhad\tO\nwith\tO\nthis\tO\nunit\tO\nwas\tO\nunresolvable\tO\n.\tO\n\nIt\tO\nweighed\tB-aspectTerm\nlike\tO\nseven\tB-aspectTerm\npounds\tI-aspectTerm\nor\tO\nsomething\tO\nlike\tO\nthat\tO\n.\tO\n\n2\tO\nmonths\tO\nlater\tO\n,\tO\nthe\tO\nbattery\tB-aspectTerm\nwent\tO\n.\tO\n\nYou\tO\nmay\tO\nneed\tO\nto\tO\nspecial\tO\norder\tO\na\tO\nbag\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\ncolor\tB-aspectTerm\nis\tO\neven\tO\ncool\tO\n.\tO\n\nand\tO\nit\tO\nhas\tO\nblue\tO\nscreen\tO\ncrashed\tO\non\tO\nme\tO\ntwice\tO\n.\tO\n\nAnother\tO\ntwo\tO\nweeks\tO\nlater\tO\nand\tO\nit\tO\nwas\tO\nback\tO\nin\tO\nmy\tO\npossession\tO\n.\tO\n\nkeys\tB-aspectTerm\nare\tO\nall\tO\nin\tO\nweird\tO\nplaces\tO\nand\tO\nis\tO\nway\tO\ntoo\tO\nlarge\tO\nfor\tO\nthe\tO\nway\tO\nit\tO\nis\tO\ndesigned\tB-aspectTerm\n.\tO\n\nI\tO\n've\tO\nowned\tO\nevery\tO\n\"\tO\nPro\tO\n\"\tO\nmodel\tO\nApple\tO\nlaptop\tO\nfor\tO\nthe\tO\nlast\tO\n8\tO\nyears\tO\n,\tO\nthis\tO\nis\tO\nBY\tO\nFAR\tO\nthe\tO\nWORST\tO\none\tO\nI\tO\n've\tO\never\tO\nhad\tO\n.\tO\n\nWe\tO\npurchase\tO\nthe\tO\nDell\tO\nXPS\tO\nseveral\tO\nyears\tO\nago\tO\nfor\tO\nmy\tO\nhome\tO\nbusiness\tO\n.\tO\n\nHave\tO\npurchased\tO\nmany\tO\nproducts\tO\nover\tO\nthe\tO\nyears\tO\nfrom\tO\nMacConnection\tO\nand\tO\nthis\tO\ntransaction\tO\n,\tO\nlike\tO\nall\tO\nthe\tO\nothers\tO\n,\tO\nwe\tO\nsmoothly\tO\nwith\tO\nno\tO\nproblems\tO\n.\tO\n\nI\tO\nwould\tO\nrecommend\tO\nanyone\tO\nto\tO\nbuy\tO\nfrom\tO\npcconnection\tO\nexpress\tO\n.\tO\n\nYes\tO\n,\tO\na\tO\nMac\tO\nis\tO\nmuch\tO\nmore\tO\nmoney\tO\nthan\tO\nthe\tO\naverage\tO\nlaptop\tO\nout\tO\nthere\tO\n,\tO\nbut\tO\nthere\tO\nis\tO\nno\tO\ncomparison\tO\nin\tO\nstyle\tB-aspectTerm\n,\tO\nspeed\tB-aspectTerm\nand\tO\njust\tO\ncool\tO\nfactor\tO\n.\tO\n\nHe\tO\ngave\tO\nme\tO\nthis\tO\nPC\tO\nabout\tO\n3\tO\nyears\tO\nago\tO\nand\tO\nup\tO\nto\tO\nthis\tO\npoint\tO\ni\tO\nm\tO\nstill\tO\nsitting\tO\nhere\tO\nusing\tO\nit\tO\n.\tO\n\nI\tO\n'm\tO\npleased\tO\n.\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\nfeels\tO\ngood\tO\nand\tO\nI\tO\ntype\tO\njust\tO\nfine\tO\non\tO\nit\tO\n.\tO\n\nWith\tO\na\tO\nhealthy\tO\npessimism\tO\n,\tO\nI\tO\ntook\tO\nthe\tO\nmachine\tO\nhome\tO\nand\tO\ntried\tO\nto\tO\nfind\tO\na\tO\nflaw\tO\n.\tO\n\nShiny\tO\nThis\tO\nLaptop\tO\nis\tO\nthe\tO\nBest\tO\nof\tO\nthe\tO\nbest\tO\n!\tO\n\nI\tO\nthought\tO\nthe\tO\nwhite\tO\nMac\tO\ncomputers\tO\nlooked\tO\ndirty\tO\ntoo\tO\nquicly\tO\nwhere\tO\nyou\tO\nuse\tO\nthe\tO\nmousepad\tB-aspectTerm\nand\tO\nwhere\tO\nyou\tO\nplace\tO\nyour\tO\nhands\tO\nwhen\tO\ntyping\tO\n.\tO\n\nAnd\tO\nnot\tO\nto\tO\nmention\tO\nafter\tO\nusing\tO\nit\tO\nfor\tO\na\tO\nfew\tO\nmonths\tO\nor\tO\nso\tO\n,\tO\nthe\tO\nbattery\tB-aspectTerm\nwill\tO\nslowly\tO\nless\tO\nand\tO\nless\tO\nhold\tO\na\tO\ncharge\tO\nuntil\tO\nyou\tO\nca\tO\nn't\tO\nleave\tO\nit\tO\nunplugged\tO\nfor\tO\nmore\tO\nthan\tO\n5\tO\nminutes\tO\nwithout\tO\nthe\tO\nthing\tO\ndying\tO\n.\tO\n\nDo\tO\nn't\tO\nwaste\tO\ntheir\tO\nmoney\tO\n,\tO\nsave\tO\nit\tO\nand\tO\nbut\tO\na\tO\nmac\tO\n.\tO\n\nMoney\tO\nand\tO\ntime\tO\nwell\tO\nspent\tO\n!\tO\n\nGradually\tO\nthe\tO\nfreezing\tO\nscreen\tO\nevolved\tO\ninto\tO\na\tO\nscreen\tO\nthat\tO\nfroze\tO\nin\tO\nweird\tO\nshapes\tO\n.\tO\n\nBEST\tO\nBUY\tO\n-\tO\n5\tO\nSTARS\tO\n+\tO\n+\tO\n+\tO\n(\tO\nsales\tB-aspectTerm\n,\tO\nservice\tB-aspectTerm\n,\tO\nrespect\tO\nfor\tO\nold\tO\nmen\tO\nwho\tO\nare\tO\nn't\tO\nfamiliar\tO\nwith\tO\nthe\tO\ntechnology\tO\n)\tO\nDELL\tO\nCOMPUTERS\tO\n-\tO\n3\tO\nstars\tO\nDELL\tB-aspectTerm\nSUPPORT\tI-aspectTerm\n-\tO\nowes\tO\na\tO\nme\tO\na\tO\ncouple\tO\n\nGood\tO\nlaptop\tO\nfor\tO\nthe\tO\nmoney\tO\n.\tO\n\nI\tO\nlike\tO\nthe\tO\nlaptop\tO\noverall\tO\n.\tO\n\nI\tO\nnow\tO\ntravel\tO\nwith\tO\nthis\tO\nlaptop\tO\nand\tO\nmy\tO\nwork\tO\nPC\tO\n.\tO\n\nI\tO\nam\tO\nhowever\tO\npleased\tO\nthat\tO\nit\tO\nis\tO\nstill\tO\nhanging\tO\nin\tO\nthere\tO\n.\tO\n\nBoth\tO\nmy\tO\nhusband\tO\nand\tO\nI\tO\nhave\tO\nthis\tO\nmodel\tO\nToshiba\tO\n.\tO\n\nno\tO\ncomplaints\tO\nwith\tO\ntheir\tO\ndesktop\tO\n,\tO\nand\tO\nmaybe\tO\nbecause\tO\nit\tO\njust\tO\nsits\tO\non\tO\nyour\tO\ndesktop\tO\n,\tO\nand\tO\nyou\tO\ndo\tO\nn't\tO\ncarry\tO\nit\tO\naround\tO\n,\tO\nwhich\tO\ncould\tO\njar\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n,\tO\nor\tO\nthe\tO\nmotherboard\tB-aspectTerm\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tB-aspectTerm\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tO\nup\tO\nfor\tO\nit\tO\nin\tO\nspeed\tB-aspectTerm\n,\tO\nconstruction\tB-aspectTerm\nquality\tI-aspectTerm\n,\tO\nand\tO\nlongevity\tB-aspectTerm\n.\tO\n\nSince\tO\nI\tO\nkeyboard\tO\nover\tO\n100\tO\nwpm\tO\n,\tO\nI\tO\nlook\tO\nfor\tO\na\tO\nunit\tO\nthat\tO\nhas\tO\na\tO\ncomfortble\tO\nkeyboard\tB-aspectTerm\n(\tO\nno\tO\nkeys\tB-aspectTerm\nsticking\tO\nor\tO\nlagging\tO\n,\tO\nstrange\tO\nconfiguration\tB-aspectTerm\nof\tI-aspectTerm\n\"\tI-aspectTerm\nextra\tI-aspectTerm\nkey\tI-aspectTerm\n\"\tI-aspectTerm\n,\tO\netc\tO\n.\tO\n\n)\tO\nI\tO\nalso\tO\ntried\tO\nthe\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\nand\tO\ncompared\tO\nit\tO\nto\tO\nother\tO\nnetbooks\tO\nin\tO\nthe\tO\nstore\tO\n.\tO\n\nIt\tO\nabsolutely\tO\nis\tO\nmore\tO\nexpensive\tO\nthan\tO\nmost\tO\nPC\tO\nlaptops\tO\n,\tO\nbut\tO\nthe\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\n,\tO\nsecurity\tB-aspectTerm\n,\tO\nand\tO\nminimal\tO\nproblems\tO\nthat\tO\nhave\tO\narisen\tO\nmake\tO\nit\tO\nwell\tO\nworth\tO\nthe\tO\npricetag\tB-aspectTerm\n.\tO\n\nIt\tO\ngets\tO\nstuck\tO\nall\tO\nof\tO\nthe\tO\ntime\tO\nyou\tO\nuse\tO\nit\tB-aspectTerm\n,\tO\nand\tO\nyou\tO\nhave\tO\nto\tO\nkeep\tO\ntapping\tO\non\tO\nit\tO\nto\tO\nget\tO\nit\tO\nto\tO\nwork\tO\n.\tB-aspectTerm\n\nlots\tO\nof\tO\npreloaded\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nSony\tO\n,\tO\nAcer\tO\n,\tO\nDell\tO\n,\tO\nPackard\tO\nBell\tO\nand\tO\nToshiba\tO\n.\tO\n\nand\tO\nthen\tO\n,\tO\na\tO\nguy\tO\ncame\tO\nout\tO\nto\tO\nserve\tO\nme\tO\ninstead\tO\n.\tO\n\nBreaking\tO\nwithin\tO\n1\tO\nyear\tO\nof\tO\npurchase\tO\nand\tO\nspeaking\tO\nto\tO\n4\tO\n+\tO\npeople\tO\nto\tO\nreport\tO\nthe\tO\ndamaged\tO\npart\tO\nwill\tO\nbe\tO\nreturned\tO\nlate\tO\n!\tO\n\nHave\tO\nreturned\tO\nthat\tO\nlaptop\tO\nunused\tO\n.\tO\n\nWill\tO\nprobably\tO\nnever\tO\nbuy\tO\na\tO\nHP\tO\nagain\tO\n.\tO\n\nI\tO\ngot\tO\ntired\tO\nof\tO\nbuying\tO\nlaptops\tO\nand\tO\nhaving\tO\nthem\tO\nstop\tO\nworking\tO\nafter\tO\na\tO\nyear\tO\n.\tO\n\nI\tO\nshould\tO\nhave\tO\nbeen\tO\nmore\tO\nobservant\tO\n.\tO\n\nI\tO\nwish\tO\nit\tO\nhad\tO\na\tO\nwebcam\tB-aspectTerm\nthough\tO\n,\tO\nthen\tO\nit\tO\nwould\tO\nbe\tO\nperfect\tO\n!\tO\n\nMy\tO\nfavorite\tO\npart\tO\nof\tO\nthis\tO\ncomputer\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\na\tO\nvga\tB-aspectTerm\nport\tI-aspectTerm\nso\tO\nI\tO\ncan\tO\nconnect\tO\nit\tO\nto\tO\na\tO\nbigger\tO\nscreen\tB-aspectTerm\n.\tO\n\nAnother\tO\nthing\tO\nI\tO\nmight\tO\nadd\tO\nis\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nexcellent\tO\n.\tO\n\nOne\tO\ndrawback\tO\n,\tO\nI\tO\nwish\tO\nthe\tO\nkeys\tB-aspectTerm\nwere\tO\nbacklit\tO\n.\tO\n\nWhen\tO\nthe\tO\nbuyer\tO\nreturned\tO\nit\tO\nWal\tO\nMart\tO\njust\tO\nboxed\tO\nit\tO\n,\tO\ntaped\tO\nit\tO\nshut\tO\nresold\tO\nit\tO\nas\tO\nnew\tO\n.\tO\n\nWhat\tO\na\tO\ngreat\tO\nlittle\tO\nlaptop\tO\n.\tO\n\nAcer\tO\nwas\tO\nno\tO\nhelp\tO\nand\tO\nGarmin\tO\ncould\tO\nnot\tO\ndetermine\tO\nthe\tO\nproblem(after\tO\nspending\tO\nabout\tO\n2\tO\nhours\tO\nwith\tO\nme\tO\n)\tO\n,\tO\nso\tO\nI\tO\nreturned\tO\nit\tO\nand\tO\npurchased\tO\na\tO\nToshiba\tO\nR700\tO\nthat\tO\nseems\tO\neven\tO\nnicer\tO\nand\tO\nI\tO\nwas\tO\nable\tO\nto\tO\nload\tO\nall\tO\nof\tO\nmy\tO\nsoftware\tB-aspectTerm\nwith\tO\nno\tO\nproblem\tO\n.\tO\n\nI\tO\nwish\tO\nthe\tO\nvolume\tB-aspectTerm\ncould\tO\nbe\tO\nlouder\tO\nand\tO\nthe\tO\nmouse\tB-aspectTerm\ndid\tO\nnt\tO\nbreak\tO\nafter\tO\nonly\tO\na\tO\nmonth\tO\n.\tO\n\nI\tO\nplay\tO\na\tO\nlot\tO\nof\tO\ncasual\tO\ngames\tO\nonline\tO\n,\tO\nand\tO\nthe\tO\ntouchpad\tB-aspectTerm\nis\tO\nvery\tO\nresponsive\tO\n.\tO\n\nGranted\tO\n,\tO\nit\tO\n's\tO\nstill\tO\na\tO\nvery\tO\nnew\tO\nlaptop\tO\nbut\tO\nin\tO\ncomparison\tO\nto\tO\nmy\tO\nprevious\tO\nlaptops\tO\nand\tO\ndesktops\tO\n,\tO\nmy\tO\nMac\tO\nboots\tB-aspectTerm\nup\tI-aspectTerm\nnoticeably\tO\nquicker\tO\n.\tO\n\nIt\tO\ncaught\tO\na\tO\nvirus\tO\nthat\tO\ncompletely\tO\nwiped\tO\nout\tO\nmy\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nin\tO\na\tO\nmatter\tO\nof\tO\nhours\tO\n.\tO\n\nWOULD\tO\nPAY\tO\nMORE\tO\nFOR\tO\nIT\tO\nIF\tO\nI\tO\nHAD\tO\nTOO\tO\n!\tO\n\nCould\tO\nn't\tO\nkeep\tO\na\tO\npage\tO\nup\tO\nyou\tO\nwere\tO\nworking\tO\non\tO\n!\tO\n\nIt\tO\nis\tO\neverything\tO\nI\tO\n'd\tO\nhoped\tO\nit\tO\nwould\tO\nbe\tO\nfrom\tO\na\tO\nlook\tB-aspectTerm\nand\tI-aspectTerm\nfeel\tI-aspectTerm\nstandpoint\tI-aspectTerm\n,\tO\nbut\tO\nsomehow\tO\na\tO\nbit\tO\nmore\tO\nsturdy\tO\n.\tO\n\nthe\tO\nonly\tO\nfact\tO\ni\tO\ndo\tO\nnt\tO\nlike\tO\nabout\tO\napples\tO\nis\tO\nthey\tO\ngenerally\tO\nuse\tO\nsafari\tB-aspectTerm\nand\tO\ni\tO\ndo\tO\nnt\tO\nuse\tO\nsafari\tB-aspectTerm\nbut\tO\nafter\tO\ni\tO\ninstall\tO\nMozzilla\tB-aspectTerm\nfirfox\tI-aspectTerm\ni\tO\nlove\tO\nevery\tO\nsingle\tO\nbit\tO\nabout\tO\nit\tO\n.\tO\n\nThe\tO\nBluetooth\tB-aspectTerm\nwas\tO\nnot\tO\nthere\tO\nat\tO\nall\tO\n,\tO\nand\tO\nthe\tO\nfingerprint\tB-aspectTerm\nreader\tI-aspectTerm\ndriver\tI-aspectTerm\nwould\tO\nbe\tO\nthere\tO\n,\tO\nbut\tO\nthe\tO\nsoftware\tB-aspectTerm\nwould\tO\nhang\tO\nafter\tO\ninstallation\tO\nwas\tO\n1/2\tO\nway\tO\ndone\tO\n.\tO\n\nGreat\tO\nbattery\tB-aspectTerm\n,\tO\nspeed\tB-aspectTerm\n,\tO\ndisplay\tB-aspectTerm\n.\tO\n\nI\tO\nwould\tO\nnot\tO\nrecommend\tO\nthis\tO\nproduct\tO\nto\tO\nanyone\tO\n.\tO\n\nI\tO\nlike\tO\nto\tO\nuse\tO\nit\tO\nat\tO\nthe\tO\nrace\tO\ntrack\tO\nto\tO\nhandiecap\tO\nthe\tO\nhorse\tO\nraces\tO\n.\tO\n\nI\tO\nwas\tO\ngiven\tO\na\tO\nMac\tO\nas\tO\na\tO\nbirthday\tO\npresent\tO\nand\tO\ncould\tO\nn't\tO\nbe\tO\nhappier\tO\nwith\tO\nit\tO\n3\tO\nyears\tO\nlater\tO\n.\tO\n\nThe\tO\ndelivery\tB-aspectTerm\nwas\tO\nfast\tO\n,\tO\nand\tO\nI\tO\nwould\tO\nnot\tO\nhesitate\tO\nto\tO\npurchase\tO\nthis\tO\nlaptop\tO\nagain\tO\n.\tO\n\nI\tO\n've\tO\nbeen\tO\nimpressed\tO\nwith\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nand\tO\nthe\tO\nperformance\tB-aspectTerm\nfor\tO\nsuch\tO\na\tO\nsmall\tO\namount\tO\nof\tO\nmemory\tB-aspectTerm\n.\tO\n\ndo\tO\na\tO\nquick\tO\nsearch\tO\non\tO\nthe\tO\ninternet\tO\nsee\tO\nif\tO\ni\tO\nm\tO\nthe\tO\nonly\tO\none\tO\n.\tO\n\nI\tO\n'm\tO\nextremely\tO\nhappy\tO\nwith\tO\nmy\tO\npurchase\tO\nas\tO\nI\tO\nnow\tO\nhave\tO\nthe\tO\nportable\tO\npower\tO\nI\tO\nhave\tO\nbeen\tO\nlooking\tO\nfor\tO\n.\tO\n\nIt\tO\n's\tO\napplications\tB-aspectTerm\nare\tO\nterrific\tO\n,\tO\nincluding\tO\nthe\tO\nreplacements\tO\nfor\tO\nMicrosoft\tB-aspectTerm\noffice\tI-aspectTerm\n.\tO\n\nthey\tO\nimproved\tO\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tB-aspectTerm\n,\tO\nappearance\tB-aspectTerm\n,\tO\ncooling\tB-aspectTerm\nsystem\tI-aspectTerm\n,\tO\ngraphics\tB-aspectTerm\ncard\tI-aspectTerm\n,\tO\netc\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nwebcam\tI-aspectTerm\nand\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nmic\tI-aspectTerm\nwere\tO\nshorting\tO\nout\tO\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tO\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tO\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tB-aspectTerm\nand\tO\nmic\tB-aspectTerm\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nIs\tO\nthis\tO\npartially\tO\ndue\tO\nto\tO\nthe\tO\nfact\tO\nthat\tO\nit\tO\nis\tO\nrunning\tO\nWindows\tB-aspectTerm\nVista\tI-aspectTerm\n?\tO\n\nYou\tO\nmight\tO\nthink\tO\n,\tO\nI\tO\nam\tO\nnew\tO\nin\tO\nthis\tO\ngame\tO\n,\tO\nbut\tO\nI\tO\nam\tO\na\tO\ngadget\tO\nlover\tO\n,\tO\nand\tO\nhave\tO\nhad\tO\nmore\tO\nthan\tO\n2\tO\ndozens\tO\nlaptops\tO\nin\tO\nthe\tO\npast\tO\n15\tO\nyears\tO\n,\tO\nand\tO\nnone\tO\ngets\tO\nthis\tO\nhot\tO\n,\tO\nthat\tO\nfast\tO\n.\tO\n\nI\tO\nwas\tO\ninformed\tO\nthat\tO\nI\tO\nneed\tO\nto\tO\ncall\tO\nsome\tO\n0900\tO\nnumber\tO\nfirst\tO\n.\tO\n\nI\tO\nreally\tO\nwanted\tO\na\tO\nMac\tO\nover\tO\na\tO\npc\tO\nbecause\tO\nI\tO\nused\tO\na\tO\nMac\tO\nin\tO\nhigh\tO\nschool\tO\n.\tO\n\n1\tO\n)\tO\nPayed\tO\n$\tO\n2200\tO\nfor\tO\na\tO\n\"\tO\npremium\tO\n\"\tO\nlaptop\tO\n\nI\tO\nBOUGHT\tO\nTHEM\tO\nFOR\tO\nMY\tO\nCOLLEGE\tO\nAGE\tO\nGRANDCHILDREN\tO\nAND\tO\nTHESE\tO\nMACS\tO\nARE\tO\nTOTALLY\tO\nRELIABLE\tO\nAND\tO\nSUPPORT\tO\nTHEIR\tO\nCLASS\tO\nWORK\tO\n100\tO\n%\tO\nOF\tO\nTHE\tO\nTIME\tO\n.\tO\n\nThe\tO\nboard\tO\nhas\tB-aspectTerm\na\tO\nbad\tO\nconnector\tO\nwith\tB-aspectTerm\nthe\tO\npower\tO\nsupply\tB-aspectTerm\nand\tI-aspectTerm\nshortly\tO\nafter\tO\nwarrenty\tO\nexpires\tB-aspectTerm\nthe\tO\npower\tO\nsupply\tB-aspectTerm\nwill\tI-aspectTerm\nstart\tO\nhaving\tO\nissues\tO\n.\tO\n\nDo\tO\nnot\tO\npurchase\tO\nthis\tO\nlaptop\tO\n.\tO\n\nMy\tO\ndad\tO\nhas\tO\none\tO\nof\tO\nthe\tO\nvery\tO\nfirst\tO\nToshibas\tO\never\tO\nmade\tO\n,\tO\nyes\tO\nits\tO\nabit\tO\nslow\tO\nnow\tO\nbut\tO\nstill\tO\nworks\tB-aspectTerm\nwell\tO\nand\tO\ni\tO\nhooked\tO\nto\tO\nmy\tO\nethernet\tB-aspectTerm\n!\tO\n\nMostly\tO\nI\tO\nlove\tO\nthe\tO\ndrag\tB-aspectTerm\nand\tI-aspectTerm\ndrop\tI-aspectTerm\nfeature\tI-aspectTerm\n.\tO\n\noh\tO\nyeah\tO\n,\tO\nand\tO\nif\tO\nthe\tO\nfancy\tO\nwebcam\tB-aspectTerm\nbreaks\tO\nguess\tO\nwho\tO\nyou\tO\nhave\tO\nto\tO\nsend\tO\nit\tO\nto\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\n?\tO\n\nShe\tO\nbrought\tO\nout\tO\n2\tO\nother\tO\nidentical\tO\nnetbooks\tO\nand\tO\nstill\tO\ninsist\tO\nthat\tO\n\"\tO\nIt\tO\nis\tO\nlike\tO\nthat\tO\none\tO\n\"\tO\n.\tO\n\nI\tO\nordered\tO\nthrough\tO\nMacMall\tO\n,\tO\nwhich\tO\nsaved\tO\nme\tO\nthe\tO\nsales\tB-aspectTerm\ntax\tI-aspectTerm\nI\tO\nwould\tO\nhave\tO\nincurred\tO\nbuying\tO\nlocally\tO\n.\tO\n\nVery\tO\nfast\tO\nand\tO\nefficient\tO\n!\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tO\nsoftware\tB-aspectTerm\npackages\tI-aspectTerm\nthat\tO\ncame\tO\nfor\tO\nfree\tO\nincluding\tO\niWork\tB-aspectTerm\n,\tO\nGarageBand\tB-aspectTerm\n,\tO\nand\tO\niMovie\tB-aspectTerm\n.\tO\n\nBeing\tO\nvirus\tO\n-\tO\nresistant\tO\nis\tO\na\tO\nhuge\tO\nplus\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nvery\tO\nlarge\tO\nand\tO\ncrystal\tO\nclear\tO\nwith\tO\namazing\tO\ncolors\tB-aspectTerm\nand\tO\nresolution\tB-aspectTerm\n.\tO\n\nAfter\tO\na\tO\nlittle\tO\nmore\tO\nthan\tO\na\tO\nyear\tO\nof\tO\nowning\tO\nmy\tO\nMacBook\tO\nPro\tO\n,\tO\nthe\tO\nmonitor\tB-aspectTerm\nhas\tO\ncompletely\tO\ndied\tO\n.\tO\n\nIn\tO\nmy\tO\nhouse\tO\n,\tO\nHP\tO\nis\tO\na\tO\nnasty\tO\nword\tO\n.\tO\n\nThe\tO\nbrand\tO\nof\tO\niTunes\tB-aspectTerm\nhas\tO\njust\tO\nbecome\tO\ningrained\tO\nin\tO\nour\tO\nlexicon\tO\nnow\tO\n,\tO\nbut\tO\nkeep\tO\nin\tO\nmind\tO\nthat\tO\nApple\tO\nstarted\tO\nit\tO\nall\tO\n.\tO\n\nBy\tO\nthe\tO\nway\tO\nteachers\tO\n,\tO\nthey\tO\noffer\tO\na\tO\ndiscount\tO\nwhich\tO\nhelps\tO\n!\tO\n\nnow\tO\nhe\tO\nmows\tO\nyards\tO\nso\tO\nhe\tO\ncan\tO\nearn\tO\nthe\tO\nmoney\tO\nfor\tO\nthe\tO\nwireless\tO\ninternet\tO\n.\tO\n\nI\tO\nstill\tO\nsee\tO\nthe\tO\nbenefits\tO\nof\tO\na\tO\nPC\tO\nwhen\tO\nI\tO\ndo\tO\nnot\tO\nknow\tO\nhow\tO\nto\tO\ndo\tO\nsomething\tO\non\tO\nmy\tO\nmac\tO\n.\tO\n\nSize\tB-aspectTerm\n:\tO\nI\tO\nknow\tO\n13\tO\nis\tO\nsmall\tO\n(\tO\nespecially\tO\nfor\tO\na\tO\ndesktop\tO\nreplacement\tO\n)\tO\nbut\tO\nwith\tO\nan\tO\nexternal\tB-aspectTerm\nmonitor\tI-aspectTerm\n,\tO\nwho\tO\ncares\tO\n.\tO\n\nAdditional\tO\ncaveat\tO\n:\tO\nthe\tO\nbase\tB-aspectTerm\ninstallation\tI-aspectTerm\ncomes\tO\nwith\tO\nsome\tO\nToshiba\tO\n-\tO\nspecific\tO\nsoftware\tB-aspectTerm\nthat\tO\nmay\tO\nor\tO\nmay\tO\nnot\tO\nbe\tO\nto\tO\na\tO\nuser\tO\n's\tO\nliking\tO\n.\tO\n\nIt\tO\nis\tO\nheld\tO\nin\tO\nplace\tO\nmagnetically\tO\n.\tO\n\nTaking\tO\nit\tO\nback\tO\nto\tO\nBest\tO\nBuy\tO\nI\tO\nfound\tO\nthat\tO\na\tO\ntiny\tO\nplastic\tO\npiece\tO\ninside\tO\nhad\tO\nbroken\tO\n(\tO\nmanuf\tO\nissue\tB-aspectTerm\n)\tO\n.\tO\n\nIt\tO\nhas\tO\nno\tO\ncamera\tB-aspectTerm\nbut\tO\n,\tO\nI\tO\ncan\tO\nalways\tO\nbuy\tO\nand\tO\ninstall\tO\none\tO\neasy\tO\n.\tO\n\nThe\tO\ndisplay\tB-aspectTerm\nis\tO\nincredibly\tO\nbright\tO\n,\tO\nmuch\tO\nbrighter\tO\nthan\tO\nmy\tO\nPowerBook\tO\nand\tO\nvery\tO\ncrisp\tO\n.\tO\n\nWe\tO\nwere\tO\nPC\tO\nusers\tO\n.\tO\n\nThe\tO\nAMD\tB-aspectTerm\nTurin\tI-aspectTerm\nprocessor\tI-aspectTerm\nseems\tO\nto\tO\nalways\tO\nperform\tO\nso\tO\nmuch\tO\nbetter\tO\nthan\tO\nIntel\tB-aspectTerm\n.\tO\n\nAfter\tO\nthat\tO\nthe\tO\nsaid\tO\nit\tO\nwas\tO\nunder\tO\nwarranty\tO\n.\tB-aspectTerm\n\nThe\tO\nstart\tB-aspectTerm\nmenu\tI-aspectTerm\nis\tO\nnot\tO\nthe\tO\neasiest\tO\nthing\tO\nto\tO\nnavigate\tB-aspectTerm\ndue\tO\nto\tO\nthe\tO\nstacking\tO\n.\tO\n\nOnly\tO\nthing\tO\nI\tO\nwould\tO\nwant\tO\nto\tO\nadd\tO\nto\tO\nthis\tO\nis\tO\nan\tO\ninternal\tO\nbluray\tB-aspectTerm\nread\tI-aspectTerm\n/\tI-aspectTerm\nwrite\tI-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nThis\tO\ncomputer\tO\nwas\tO\nawful\tO\n,\tO\nI\tO\nwould\tO\nnever\tO\nrecomend\tO\nit\tO\nto\tO\nanother\tO\nperson\tO\n.\tO\n\nThe\tO\nservice\tB-aspectTerm\ntech\tI-aspectTerm\nsaid\tO\nhe\tO\nhad\tO\ntried\tO\nto\tO\nduplicate\tO\nthe\tO\ndamage\tO\nand\tO\nwas\tO\nn't\tO\nable\tO\nto\tO\nrecreate\tO\nit\tO\ntherefore\tO\nit\tO\nhad\tO\nto\tO\nbe\tO\ntheir\tO\ndefect\tO\n.\tO\n\nThe\tO\ntech\tB-aspectTerm\nstore\tI-aspectTerm\nI\tO\npurchased\tO\nthis\tO\nfrom\tO\nsent\tO\nit\tO\nback,,,,,eventually\tO\nI\tO\ngot\tO\na\tO\nnew\tO\nor\tO\nrepaired\tO\nmachine\tO\napproximately\tO\n3\tO\nweeks\tO\nlater\tO\n.\tO\n\nI\tO\nloved\tO\nit\tO\nthen\tO\n,\tO\nbut\tO\nunfortunately\tO\nit\tO\nwas\tO\nbefore\tO\nthe\tO\ndays\tO\nof\tO\nwireless\tO\ninternet\tO\n.\tO\n\nReally\tO\nlike\tO\nthe\tO\ntextured\tO\nsurface\tB-aspectTerm\nwhich\tO\nshows\tO\nno\tO\nfingerprints\tO\n.\tO\n\nI\tO\nWILL\tO\nNEVER\tO\nAGAIN\tO\nbuy\tO\nanother\tO\nAcer\tO\n,\tO\nnot\tO\nwill\tO\nI\tO\nbuy\tO\nGateway\tO\n,\tO\nor\tO\neMachine\tO\nas\tO\nthey\tO\nare\tO\nall\tO\nfrom\tO\nthe\tO\nsame\tO\ncompany\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nbright\tO\nand\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\nnice\tO\n;\tO\n\nI\tO\nlook\tO\nforward\tO\nto\tO\nyears\tO\nof\tO\nuse\tO\n,\tO\nit\tO\nhas\tO\nheld\tO\nup\tO\nwell\tO\nover\tO\nthe\tO\nyears\tO\nand\tO\nit\tO\nfits\tO\nmy\tO\nneeds\tO\nvery\tO\nwell\tO\n.\tO\n\nI\tO\nm\tO\nvery\tO\nhappy\tO\nwith\tO\nthis\tO\ncomputer\tO\n!\tO\n\nBut\tO\nthe\tO\nmachine\tO\nis\tO\nawesome\tO\nand\tO\niLife\tB-aspectTerm\nis\tO\ngreat\tO\nand\tO\nI\tO\nlove\tO\nSnow\tB-aspectTerm\nLeopard\tI-aspectTerm\nX.\tI-aspectTerm\n\nHigh\tO\nprice\tB-aspectTerm\ntag\tI-aspectTerm\n,\tO\nhowever\tO\n.\tO\n\nI\tO\nthought\tO\nlearning\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nwould\tO\nbe\tO\nhard\tO\n,\tO\nbut\tO\nit\tO\nis\tO\neasily\tO\npicked\tO\nup\tO\nif\tO\nyou\tO\nare\tO\nfamiliar\tO\nwith\tO\na\tO\nPC\tO\n.\tO\n\nMy\tO\nkids\tO\nhave\tO\nto\tO\ntake\tO\ntheir\tO\nPCs\tO\nin\tO\nonce\tO\na\tO\nyear\tO\nto\tO\nhave\tO\nthem\tO\n\"\tO\nde\tO\n-\tO\nbugged\tO\n\"\tO\n.\tO\n\nI\tO\nhad\tO\nstatic\tO\nin\tO\nthe\tO\noutput\tO\n,\tO\nand\tO\nI\tO\nhad\tO\nto\tO\nreduce\tO\nthe\tO\nsound\tB-aspectTerm\noutput\tI-aspectTerm\nquality\tI-aspectTerm\nto\tO\n\"\tO\nFM\tO\n\"\tO\nas\tO\nopposed\tO\nto\tO\nthe\tO\ndefault\tO\n\"\tO\nCD\tO\n.\tO\n\nIt\tO\nwas\tO\na\tO\nlaugh\tO\ntoo\tO\n!\tO\n\nSince\tO\nI\tO\npurchased\tO\nmy\tO\nToshiba\tO\nnetbook\tO\n,\tO\nI\tO\nhave\tO\nbeen\tO\nvery\tO\npleased\tO\nwith\tO\nit\tO\n,\tO\nI\tO\nhave\tO\na\tO\nlaptob\tO\nand\tO\na\tO\ndesktop\tO\n.\tO\n\nI\tO\nbought\tO\nmy\tO\nmacbook\tO\na\tO\nfew\tO\nmonths\tO\nago\tO\nand\tO\nit\tO\nhas\tO\nbeen\tO\nmy\tO\nbaby\tO\never\tO\nsince\tO\n.\tO\n\nThat\tO\nis\tO\nhow\tO\nit\tO\nis\tO\nable\tO\nto\tO\nfunction\tO\nbetter\tO\nthan\tO\nany\tO\nother\tO\nPC\tO\n.\tO\n\nI\tO\ncustom\tO\nordered\tO\nthe\tO\nmachine\tO\nfrom\tO\nHP\tO\nand\tO\ncould\tO\nNOT\tO\nunderstand\tO\nthe\tO\ntechie\tB-aspectTerm\ndue\tO\nto\tO\nhis\tO\naccent\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nlightweight\tO\n.\tO\n\nI\tO\nwent\tO\nto\tO\nToshiba\tB-aspectTerm\nonline\tI-aspectTerm\nhelp\tI-aspectTerm\nand\tO\nfound\tO\nsome\tO\nsuggestions\tO\nto\tO\nfix\tO\nit\tO\n.\tO\n\nIt\tO\nis\tO\na\tO\nbit\tO\nheavy\tO\n.\tO\n\nafter\tO\ntrying\tO\nto\tO\nget\tO\nsome\tO\nhelp\tO\nhe\tO\ndisconnected\tO\non\tO\nme\tO\n.\tO\n\nThey\tO\nalso\tO\nhave\tO\na\tO\nlonger\tO\nservice\tB-aspectTerm\nlife\tI-aspectTerm\nthan\tO\nother\tO\ncomputers\tO\n(\tO\nI\tO\nhave\tO\nseveral\tO\nfriends\tO\nwho\tO\nstill\tO\nuse\tO\nthe\tO\nolder\tO\nApple\tO\nPowerBooks\tO\n)\tO\n.\tO\n\nIf\tO\nyou\tO\ncheck\tO\nyou\tO\nwill\tO\nfind\tO\nthe\tO\nsame\tO\nnotebook\tO\nwith\tO\nthe\tO\nabove\tO\nmissing\tO\nports\tB-aspectTerm\nand\tO\na\tO\ndual\tO\ncore\tO\nAMD\tO\nor\tO\nIntel\tO\nprocessor\tB-aspectTerm\n.\tO\n\nThis\tO\nlaptop\tO\nis\tO\na\tO\ngreat\tO\nprice\tB-aspectTerm\nand\tO\nhas\tO\na\tO\nsleek\tO\nlook\tB-aspectTerm\n.\tO\n\nI\tO\nespecially\tO\nlike\tO\nthe\tO\nkeyboard\tB-aspectTerm\nwhich\tO\nhas\tO\nchiclet\tO\ntype\tO\nkeys\tB-aspectTerm\n.\tO\n\nSmall\tO\nscreen\tB-aspectTerm\nsomewhat\tO\nlimiting\tO\nbut\tO\ngreat\tO\nfor\tO\ntravel\tO\n.\tO\n\nOne\tO\nof\tO\nthe\tO\nprimary\tO\nreasons\tO\nwhy\tO\nI\tO\npurchased\tO\nan\tO\nIPad\tO\nwas\tO\nto\tO\nstore\tO\nphotographs\tO\nso\tO\nthat\tO\nI\tO\ncould\tO\nshow\tO\nto\tO\nmy\tO\ncustomers\tO\n.\tO\n\nRuns\tO\nHot\tO\nI\tO\nthought\tO\nwe\tO\nwere\tO\npaying\tO\nfor\tO\nquality\tO\nin\tO\nour\tO\ndecision\tO\nto\tO\nbuy\tO\nan\tO\nApple\tO\nproduct\tO\n.\tO\n\nFor\tO\nthe\tO\nnot\tO\nso\tO\ngood\tO\n,\tO\nI\tO\ngot\tO\nthe\tO\nstock\tB-aspectTerm\nscreen\tI-aspectTerm\n-\tO\nwhich\tO\nis\tO\nVERY\tO\nglossy\tO\n.\tO\n\nThe\tO\ngray\tB-aspectTerm\ncolor\tI-aspectTerm\nwas\tO\na\tO\ngood\tO\nchoice\tO\n.\tO\n\nThis\tO\nwas\tO\nthe\tO\nsecond\tO\ncomputer\tO\nand\tO\nbrand\tO\nbought\tO\nthat\tO\nday\tO\n.\tO\n\nBuy\tO\nthis\tO\n.\tO\n\nVERY\tO\ndisappointing\tO\n:\tO\n\nI\tO\nlove\tO\nthis\tO\nproduct\tO\nbecause\tO\nit\tO\nis\tO\nToshiba\tO\nand\tO\nits\tO\n15.6\tO\n\"\tO\n.\tO\n\nI\tO\nwould\tO\nlike\tO\nto\tO\nhave\tO\nvolume\tB-aspectTerm\nbuttons\tI-aspectTerm\nrather\tO\nthan\tO\nthe\tO\nadjustment\tO\nthat\tO\nis\tO\non\tO\nthe\tO\nfront\tO\n.\tO\n\nThis\tO\nis\tO\nmy\tO\nfirst\tO\ncomputer\tO\npurchase\tO\n\nPeople\tO\nknow\tO\nwhat\tO\nthey\tO\nare\tO\ntalking\tO\nabout\tO\nand\tO\nthey\tO\nhave\tO\npride\tO\nin\tO\nthe\tO\nproduct\tO\nthat\tO\nthey\tO\nare\tO\nselling\tO\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\na\tO\nAMD\tO\nSemprom\tO\nat\tO\n2.1\tO\nghz\tO\nis\tO\na\tO\nbummer\tO\nit\tO\ndoes\tO\nnot\tO\nhave\tO\nthe\tO\npower\tO\nfor\tO\nHD\tO\nor\tO\nheavy\tO\ncomputing\tB-aspectTerm\n.\tO\n\nWould\tO\nHIGHLY\tO\nrecommend\tO\nthis\tO\nnetbook\tO\nthough\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nseveral\tO\nmachines\tO\nover\tO\nthe\tO\nyears\tO\n,\tO\nboth\tO\nfor\tO\npersonal\tO\nand\tO\nbusiness\tO\nuse\tO\n.\tO\n\nI\tO\nbought\tO\na\tO\nprotector\tB-aspectTerm\nfor\tO\nmy\tO\nkey\tB-aspectTerm\npad\tI-aspectTerm\nand\tO\nit\tO\nworks\tO\ngreat\tO\n:)\tO\n\nThe\tO\nmagnetic\tB-aspectTerm\nplug\tI-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\npower\tI-aspectTerm\ncharging\tI-aspectTerm\npower\tI-aspectTerm\ncord\tI-aspectTerm\nis\tO\ngreat\tO\n(\tO\nI\tO\neven\tO\nput\tO\nit\tO\nto\tO\nthe\tO\ntest\tO\nby\tO\naccident)-\tO\nexcellent\tO\ninnovation\tO\n!\tO\n\nWell\tO\ni\tO\ngot\tO\nthis\tO\ncomputer\tO\nfrom\tO\nBest\tO\nBuy\tO\nand\tO\nI\tO\nhave\tO\nhad\tO\nnothing\tO\nbut\tO\nproblems\tO\nI\tO\nbought\tO\nthe\tO\ncomputer\tO\nwith\tO\na\tO\nvirus\tO\n.....\tO\n\nIt\tO\nseems\tO\nthey\tO\ncould\tO\nhave\tO\nupdated\tO\nXP\tB-aspectTerm\nand\tO\ndone\tO\nwithout\tO\ncreating\tO\nVista\tB-aspectTerm\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tO\n,\tB-aspectTerm\nfast\tO\nand\tO\nhas\tO\ngreat\tO\ngraphics\tO\nfor\tB-aspectTerm\nthe\tO\nmoney\tO\n.\tO\n\nI\tO\ndecided\tO\nI\tO\nwanted\tO\na\tO\nlaptop\tO\nso\tO\nI\tO\nwent\tO\ninto\tO\nthe\tO\nBBY\tO\nstore\tO\n.\tO\n\nI\tO\nlike\tO\nhow\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nis\tO\nso\tO\nsimple\tO\nand\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nWhile\tO\nApple\tO\n's\tO\nsaving\tO\ngrace\tO\nis\tO\nthe\tO\nfact\tO\nthat\tO\nthey\tO\nat\tO\nleast\tO\nstand\tO\nbehind\tO\ntheir\tO\nproducts\tO\n,\tO\nand\tO\ntheir\tO\nsupport\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nit\tO\nwould\tO\nbe\tO\nnice\tO\nif\tO\ntheir\tO\nproducts\tO\nwere\tO\nmore\tO\nreliable\tO\nto\tO\njustify\tO\nthe\tO\npremium\tO\n.\tO\n\nIn\tO\nthe\tO\nthree\tO\nyears\tO\nI\tO\n've\tO\nhad\tO\nmy\tO\nMacBook\tO\nPro\tO\n,\tO\nI\tO\nhave\tO\nnever\tO\nhad\tO\na\tO\nvirus\tO\non\tO\nmy\tO\ncomputer\tO\n,\tO\nand\tO\nI\tO\ndo\tO\na\tO\nlot\tO\nof\tO\nwork\tO\non\tO\nthe\tO\ninternet\tO\n.\tO\n\nI\tO\nwas\tO\nready\tO\nto\tO\ntake\tO\nit\tO\nback\tO\nfor\tO\na\tO\nrefund\tO\n,\tO\nbut\tO\nthe\tO\nGeek\tB-aspectTerm\nSquad\tI-aspectTerm\ncamed\tO\nthrough\tO\nand\tO\npointed\tO\nme\tO\nin\tO\nthe\tO\nright\tO\ndirection\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nlaptops\tO\nin\tO\nthe\tO\npast\tO\nand\tO\nI\tO\nthought\tO\nwhy\tO\nnot\tO\ngive\tO\nthese\tO\nsmall\tO\nnetbooks\tO\na\tO\ntry\tO\n.\tO\n\nIt\tO\nca\tO\nn't\tO\nget\tO\nany\tO\nbetter\tO\n.\tO\n\nAll\tO\nthe\tO\nproblems\tO\nI\tO\nhave\tO\nhad\tO\nwith\tO\nPC\tO\n's\tO\nare\tO\nsolved\tO\nwith\tO\na\tO\nMac\tO\n:\tO\nthe\tO\nissue\tO\nof\tO\noverheating\tO\n-\tO\nmy\tO\nDell\tO\nwas\tO\nalways\tO\noverheating\tO\nand\tO\nnot\tO\nworking\tO\nproperly\tO\nor\tO\nsimply\tO\nshutting\tO\noff\tO\n,\tO\nand\tO\nthe\tO\nissue\tO\nof\tO\nviruses\tO\nand\tO\ncontaminants\tO\n-\tO\nmy\tO\nHP\tO\ncompletely\tO\nquit\tO\nworking\tO\nwithin2\tO\nyears\tO\nof\tO\npurchasing\tO\nit\tO\n,\tO\nwith\tO\nno\tO\ninexpensive\tO\nway\tO\nof\tO\nfixing\tO\nit\tO\n.\tO\n\nonly\tO\ngood\tO\nthing\tO\nis\tO\nthe\tO\ngraphics\tB-aspectTerm\nquality\tI-aspectTerm\n.\tO\n\nThe\tO\nother\tO\nlock\tO\n-\tO\nup\tO\nproblems\tO\nare\tO\nfrom\tO\na\tO\nmyriad\tO\nof\tO\ncauses\tO\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nbeing\tO\na\tO\ncorrupted\tO\nversion\tO\nof\tO\nAppleworks\tB-aspectTerm\nwhich\tO\ncan\tO\nrender\tO\nthe\tO\nbrowser\tB-aspectTerm\nuseless\tO\n.\tO\n\nIn\tO\nshort\tO\nI\tO\nwould\tO\nnever\tO\nbuy\tO\na\tO\nCompaq\tO\nagain\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\n15\tO\n\"\tO\nMacBook\tO\nPro\tO\n.\tO\n\nbreaks\tO\neasily\tO\n.\tO\n\nThe\tO\npaint\tB-aspectTerm\nwears\tO\noff\tO\neasily\tO\ndue\tO\nto\tO\nthe\tO\nkeyboard\tB-aspectTerm\nbeing\tO\nfarther\tO\nback\tO\nthan\tO\nusual\tO\n.\tO\n\nThat\tO\n's\tO\nright\tO\n,\tO\nno\tO\npower\tO\n,\tO\nabsolutely\tO\nNOTHING\tO\n.\tO\n\nI\tO\nhad\tO\npurchased\tO\nit\tO\nfrom\tO\na\tO\nmajor\tO\nelectronics\tO\nstore\tO\nand\tO\ntook\tO\nit\tO\nto\tO\ntheir\tO\nservice\tB-aspectTerm\ndepartment\tI-aspectTerm\nto\tO\nfind\tO\nout\tO\nwhat\tO\nthe\tO\nproblem\tO\nwas\tO\n.\tO\n\nThe\tO\nstore\tO\nhonored\tO\ntheir\tO\nwarrenty\tB-aspectTerm\nand\tO\nmade\tO\nthe\tO\ncomment\tO\nthat\tO\nthey\tO\ndo\tO\nn't\tO\neven\tO\nrecommend\tO\nthe\tO\nHP\tO\nbrand\tO\nbecause\tO\nof\tO\nthe\tO\nproblems\tO\nwith\tO\ntheir\tO\nwarrentys\tB-aspectTerm\n.\tO\n\nBut\tO\nI\tO\nwas\tO\nwrong\tO\n.\tO\n\nNO\tO\ngood\tO\n.\tO\n\nI\tO\nalways\tO\nuse\tO\na\tO\nbackup\tO\nhard\tB-aspectTerm\ndisk\tI-aspectTerm\nto\tO\nstore\tO\nimportant\tO\nfiles\tO\nat\tO\nall\tO\ntimes\tO\n.\tO\n\nThey\tO\nsent\tO\nout\tO\nthe\tO\nbox\tO\nright\tO\naway\tO\nfor\tO\nme\tO\nto\tO\nsend\tO\nin\tO\nmy\tO\ncomputer\tO\n,\tO\nthey\tO\npaid\tO\npostage\tO\nand\tO\nwhatnot\tO\n,\tO\nbut\tO\nwhen\tO\nI\tO\ngot\tO\nmy\tO\ncomputer\tO\nback\tO\nit\tO\nstill\tO\nwas\tO\nn't\tO\nrunning\tB-aspectTerm\nright\tO\n,\tO\nand\tO\nnow\tO\nmy\tO\nCD\tB-aspectTerm\ndrive\tI-aspectTerm\nwas\tO\nn't\tO\nreading\tO\nanything\tO\n!\tO\n\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\nWas\tO\nthe\tO\nworst\tO\nLaptop\tO\nI\tO\n've\tO\never\tO\nbought\tO\n.\tO\n\nBut\tO\nthe\tO\nscreen\tB-aspectTerm\nsize\tI-aspectTerm\nis\tO\nnot\tO\nthat\tO\nbad\tO\nfor\tO\nemail\tO\nand\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\n.\tO\n\nOnce\tO\nI\tO\nremoved\tO\nall\tO\nthe\tO\nsoftware\tB-aspectTerm\nthe\tO\nlaptop\tO\nloads\tB-aspectTerm\nin\tO\n15\tO\n-\tO\n20\tO\nseconds\tO\n.\tO\n\nOn\tO\nmy\tO\nPowerBook\tO\nG4\tO\nI\tO\nwould\tO\nnever\tO\nuse\tO\nthe\tO\ntrackpad\tB-aspectTerm\nI\tO\nwould\tO\nuse\tO\nan\tO\nexternal\tB-aspectTerm\nmouse\tI-aspectTerm\nbecause\tO\nI\tO\ndid\tO\nn't\tO\nlike\tO\nthe\tO\ntrackpad\tB-aspectTerm\n.\tO\n\nThis\tO\ncomputer\tO\ndoes\tO\nn't\tO\ndo\tO\nthat\tO\nwell\tO\nwith\tO\ncertain\tO\ngames\tB-aspectTerm\nit\tO\nca\tO\nn't\tO\nplay\tO\nsome\tO\nand\tO\nit\tO\nbecomes\tO\ntoo\tO\nhot\tO\nwhile\tO\nplaying\tO\ngames\tO\n.\tO\n\nObviously\tO\none\tO\nof\tO\nthe\tO\nmost\tO\nimportant\tO\nfeatures\tB-aspectTerm\nof\tO\nany\tO\ncomputer\tO\nis\tO\nthe\tO\n\"\tO\nhuman\tB-aspectTerm\ninterface\tI-aspectTerm\n.\tO\n\nYeah\tO\n,\tO\nof\tO\ncourse\tO\nsmarty\tO\npants\tO\n\"\tO\nfix\tO\nit\tO\nnow\")Software\tO\n-\tO\nCompared\tO\nto\tO\nthe\tO\nearly\tO\n2011\tO\nedition\tO\nI\tO\ndid\tO\nsee\tO\ninbuilt\tB-aspectTerm\napplications\tI-aspectTerm\ncrashing\tO\nand\tO\nit\tO\nprompted\tO\nme\tO\nto\tO\nsend\tO\nthe\tO\nreport\tO\nto\tO\nApple\tO\n(\tO\nwhich\tO\nI\tO\npromptly\tO\ndid\tO\n)\tO\n.\tO\n\nThe\tO\nbody\tB-aspectTerm\nis\tO\na\tO\nbit\tO\ncheaply\tO\nmade\tO\nso\tO\nit\tO\nwill\tO\nbe\tO\ninteresting\tO\nto\tO\nsee\tO\nhow\tO\nlong\tO\nit\tO\nholds\tO\nup\tO\n.\tO\n\nThe\tO\ni5\tB-aspectTerm\nblows\tO\nmy\tO\ndesktop\tO\nout\tO\nof\tO\nthe\tO\nwater\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\nrendering\tO\nvideos\tO\n.\tO\n\nWith\tO\na\tO\nmac\tO\nyou\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tO\nabout\tO\nantivirus\tB-aspectTerm\nsoftware\tI-aspectTerm\nor\tO\nfirewall\tB-aspectTerm\n,\tO\nit\tO\n's\tO\nso\tO\nwonderful\tO\n.\tO\n\nFor\tO\nthe\tO\nuse\tO\nit\tO\nwas\tO\npurchased\tO\nfor\tO\nit\tO\nis\tO\na\tO\ngood\tO\nLaptop\tO\n.\tO\n\nAm\tO\nvery\tO\nglad\tO\nI\tO\nbought\tO\nit\tO\n,\tO\ngreat\tO\nnetbook\tO\n,\tO\nlow\tO\nprice\tB-aspectTerm\n.\tO\n\nObviously\tO\n,\tO\nthis\tO\nMacbook\tO\nis\tO\nP\tO\n-\tO\nE\tO\n-\tO\nR\tO\n-\tO\nF\tO\n-\tO\nE\tO\n-\tO\nC\tO\n-\tO\nT\tO\nfor\tO\nme\tO\nbecause\tO\nit\tO\ndoes\tO\nexactly\tO\nwhat\tO\nI\tO\nneed\tO\nin\tO\nan\tO\neasy\tO\n-\tO\nto\tO\n-\tO\nfunction\tO\nway\tO\n.\tO\n\nWorth\tO\nthe\tO\ninvestment\tO\nand\tO\ntruly\tO\na\tO\nfine\tO\npiece\tO\nof\tO\nequipment\tO\n.\tO\n\nThe\tO\nApple\tB-aspectTerm\nteam\tI-aspectTerm\nalso\tO\nassists\tO\nyou\tO\nvery\tO\nnicely\tO\nwhen\tO\nchoosing\tO\nwhich\tO\ncomputer\tO\nis\tO\nright\tO\nfor\tO\nyou\tO\n:)\tO\n\nSummary\tO\n:\tO\nDo\tO\nnt\tO\nbuy\tO\nHP\tO\n.\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tO\nis\tO\nVista\tB-aspectTerm\n,\tO\nyet\tO\nI\tO\nknow\tO\nVista\tB-aspectTerm\nis\tO\nn't\tO\nthe\tO\nentire\tO\nissue\tO\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tO\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tB-aspectTerm\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n)\tO\n.\tO\n\nThe\tO\nvideo\tB-aspectTerm\nchat\tI-aspectTerm\nis\tO\nthe\tO\nonly\tO\nthing\tO\nthat\tO\nis\tO\niffy\tO\nabout\tO\nit\tO\nbut\tO\ni\tO\nm\tO\nsure\tO\nonce\tO\nthey\tO\nunpdate\tO\nthe\tO\nnext\tO\nversion\tO\non\tO\nthe\tO\nmacbook\tO\nbook\tO\nthe\tO\nquality\tB-aspectTerm\nof\tO\nit\tO\nwill\tO\nbe\tO\nbetter\tO\n.\tO\n\nYou\tO\n'll\tO\nneed\tO\nto\tO\nupgrade\tO\nand\tO\npay\tO\na\tO\nlittle\tO\nmore\tO\nfor\tO\nthem\tO\n.\tO\n\nit\tO\nis\tO\nhard\tO\nto\tO\nfix\tO\nand\tO\nmakes\tO\nit\tO\na\tO\nhassle\tO\nto\tO\nown\tO\none\tO\n.\tO\n\nThat\tO\nwhole\tO\nexperience\tO\nwas\tO\njust\tO\nridiculous\tO\nwe\tO\nsent\tO\nit\tO\nin\tO\nand\tO\nafter\tO\nthey\tO\ntold\tO\nus\tO\nthat\tO\nwe\tO\nhad\tO\nto\tO\npay\tO\n$\tO\n175\tO\nto\tO\nfix\tO\nit\tO\nwe\tO\nwere\tO\nlike\tO\nwe\tO\nwill\tO\njust\tO\nby\tO\na\tO\nportable\tO\nmouse\tB-aspectTerm\nwhich\tO\nwould\tO\nbe\tO\nway\tO\ncheaper\tO\nbut\tO\nthey\tO\nrefused\tO\nto\tO\nsend\tO\nthe\tO\nlaptop\tO\nback\tO\nuntil\tO\nwe\tO\npaid\tO\nthe\tO\n$\tO\n175\tO\nand\tO\nit\tO\nwas\tO\nfixed\tO\n.\tO\n\nMacs\tO\nare\tO\ndesigned\tO\nfor\tO\nthe\tO\n\"\tO\nfrontal\tO\nlobe\tO\nchallenged\tO\n\"\tO\npeople\tO\nout\tO\nthere\tO\n.\tO\n\nFan\tB-aspectTerm\nvents\tO\nto\tO\nthe\tO\nside\tO\n,\tO\nso\tO\nno\tO\ncooling\tB-aspectTerm\npad\tI-aspectTerm\nneeded\tO\n,\tO\ngreat\tO\nfeature\tB-aspectTerm\n!\tO\n\ni\tO\nuse\tO\nmy\tO\nmac\tO\nall\tO\nthe\tO\ntime\tO\n,\tO\ni\tO\nlove\tO\nthe\tO\nsoftware\tB-aspectTerm\n,\tO\nthe\tO\nway\tO\nit\tO\ntakes\tO\na\tO\nshort\tO\ntime\tO\nto\tO\nload\tO\nthings\tO\n,\tO\nhow\tO\neasy\tO\nit\tO\nis\tO\nto\tO\nuse\tO\nand\tO\nmost\tO\nof\tO\nall\tO\nhow\tO\nyou\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tO\nabout\tO\nviruses\tO\n.\tO\n\nWasted\tO\nme\tO\nat\tO\nleast\tO\n8\tO\nhours\tO\nof\tO\ninstallation\tB-aspectTerm\ntime\tI-aspectTerm\n.\tO\n\nIt\tO\nhas\tO\nfar\tO\nexceeded\tO\nmy\tO\nexpectations\tO\nfor\tO\npower\tB-aspectTerm\n,\tO\nstorage\tB-aspectTerm\n,\tO\nand\tO\nabilitiy\tB-aspectTerm\n.\tO\n\nA\tO\ngreat\tO\nfeature\tB-aspectTerm\nis\tO\nthe\tO\nspotlight\tB-aspectTerm\nsearch\tI-aspectTerm\n:\tO\none\tO\ncan\tO\nsearch\tO\nfor\tO\ndocuments\tO\nby\tO\nsimply\tO\ntyping\tO\na\tO\nkeyword\tO\n,\tO\nrather\tO\nthan\tO\nparsing\tO\ntens\tO\nof\tO\nfile\tO\nfolders\tO\nfor\tO\na\tO\ndocument\tO\n.\tO\n\nMy\tO\nwireless\tB-aspectTerm\nsystem\tI-aspectTerm\nwould\tO\nnot\tO\nrecognize\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nand\tO\nI\tO\ncould\tO\nn't\tO\nget\tO\nonline\tO\nto\tO\nfind\tO\nout\tO\nwhy\tO\n.\tO\n\nI\tO\nam\tO\nenjoying\tO\nit\tO\nand\tO\nthe\tO\nquality\tB-aspectTerm\nit\tO\nprovides\tO\nis\tO\ngreat\tO\n!\tO\n\nIt\tO\nis\tO\nthe\tO\nworst\tO\nlaptop\tO\never\tO\n\nSuffice\tO\nit\tO\nto\tO\nsay\tO\n,\tO\nmy\tO\nMacBook\tO\nPro\tO\nkeeps\tO\nme\tO\ngoing\tO\nwith\tO\nits\tO\nlong\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nand\tO\nblazing\tO\nspeed\tB-aspectTerm\n.\tO\n\nI\tO\n'm\tO\nnot\tO\ngoing\tO\nto\tO\nlie\tO\n,\tO\nI\tO\n've\tO\nnever\tO\nreally\tO\nliked\tO\nthe\tO\nAcer\tO\nbrand\tO\nin\tO\ngeneral\tO\n.\tO\n\nThe\tO\nOS\tB-aspectTerm\nis\tO\nalso\tO\nvery\tO\nuser\tO\nfriendly\tO\n,\tO\neven\tO\nfor\tO\nthose\tO\nthat\tO\nswitch\tO\nfrom\tO\na\tO\nPC\tO\n,\tO\nwith\tO\na\tO\nlittle\tO\npractice\tO\nyou\tO\ncan\tO\ntake\tO\nfull\tO\nadvantage\tO\nof\tO\nthis\tO\nOS\tB-aspectTerm\n!\tO\n\niTunes\tB-aspectTerm\nis\tO\na\tO\nhandy\tO\nmusic\tO\n-\tO\nmanagement\tO\nprogram\tB-aspectTerm\n,\tO\nand\tO\nit\tO\nis\tO\nessential\tO\nfor\tO\nanyone\tO\nwith\tO\nan\tO\niPod\tO\n.\tO\n\n-I\tO\ngive\tO\nup\tO\non\tO\nmy\tO\ndata\tO\n,\tO\nI\tO\njust\tO\nwant\tO\na\tO\ncomputer\tO\nreasonably\tO\nfast\tO\n...\tO\n\nWould\tO\nbuy\tO\n100\tO\nmore\tO\nof\tO\nthese\tO\nif\tO\nI\tO\ncould\tO\n.\tO\n\nwhile\tO\nit\tO\nwas\tO\nbarely\tO\na\tO\nbargin\tO\nin\tO\nthe\tO\nbegining\tO\n,\tO\ni\tO\nwould\tO\nnever\tO\npurchase\tO\nanother\tO\ndell\tO\nand\tO\nwould\tO\nnot\tO\nrecomend\tO\nthe\tO\ndell\tO\nbrand\tO\nto\tO\nothers\tO\n.\tO\n\nit\tO\nwas\tO\nshooting\tO\nsparks\tO\n!\tO\n\nGreat\tO\nproduct\tO\n.\tO\n\nMac\tO\nis\tO\nnot\tO\nmade\tO\nfor\tO\ngaming\tB-aspectTerm\n.\tO\n\nWell\tO\nI\tO\nspilled\tO\nsomething\tO\non\tO\nit\tO\nand\tO\nthey\tO\nreplaced\tO\nit\tO\nwith\tO\nthis\tO\nmodel\tO\n,\tO\nwhich\tO\ngets\tO\nhot\tO\nand\tO\nthe\tO\nbattery\tB-aspectTerm\ndoes\tO\nn't\tO\nmake\tO\nit\tO\nthrough\tO\n1\tO\nDVD\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nto\tO\ncall\tO\nApple\tB-aspectTerm\nsupport\tI-aspectTerm\nto\tO\nset\tO\nup\tO\nmy\tO\nnew\tO\nprinter\tO\nand\tO\nhave\tO\nhad\tO\nwonderful\tO\nexperiences\tO\nwith\tO\nhelpful\tO\n,\tO\nenglish\tO\nspeaking\tO\n(\tO\nfrom\tO\nVancouver\tO\n)\tO\ntechs\tB-aspectTerm\nthat\tO\nwalked\tO\nme\tO\nthrough\tO\nthe\tO\nprocesses\tO\nto\tO\nhelp\tO\nme\tO\n.\tO\n\nBut\tO\nSony\tO\nsaid\tO\nwe\tO\ncould\tO\nsend\tO\nit\tO\nback\tO\nand\tO\nbe\tO\ncharged\tO\nfor\tO\nadding\tB-aspectTerm\nthe\tI-aspectTerm\nbluetooth\tI-aspectTerm\nan\tO\nadditional\tO\nseventy\tO\nsomething\tO\ndollars\tO\n.\tO\n\nBy\tO\nthis\tO\ntime\tO\nI\tO\nwas\tO\nregretting\tO\never\tO\nSEEING\tO\nthis\tO\nmachine\tO\non\tO\nthe\tO\nshelf\tO\n!\tO\n\nToshiba\tO\nis\tO\na\tO\ngreat\tO\nbrand\tO\n,\tO\neven\tO\nthough\tO\nI\tO\nhave\tO\nn't\tO\nhad\tO\nit\tO\nfor\tO\na\tO\nlong\tO\ntime\tO\n,\tO\nI\tO\nam\tO\nvery\tO\nhappy\tO\nwith\tO\nit\tO\n!\tO\n\nI\tO\nneed\tO\ngraphic\tB-aspectTerm\npower\tI-aspectTerm\nto\tO\nrun\tO\nmy\tO\nAdobe\tB-aspectTerm\nCreative\tI-aspectTerm\napps\tI-aspectTerm\nefficiently\tO\n.\tO\n\nthe\tO\nprograms\tB-aspectTerm\nare\tO\nesay\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nare\tO\nquick\tO\nto\tO\nprocess\tO\nthis\tO\ncomputer\tO\nworks\tO\nlike\tO\na\tO\ncharm\tO\n.\tO\n\nThe\tO\nmaterials\tB-aspectTerm\nthat\tO\ncame\tO\nwith\tO\nthe\tO\ncomputer\tO\ndid\tO\nnot\tO\ninclude\tO\nthe\tO\nright\tO\n#\tO\nanywhere\tO\n.\tO\n\nSo\tO\nwhen\tO\nyou\tO\ndo\tO\ncall\tO\nto\tO\ncomplain\tO\nabout\tO\nthe\tO\nhunk\tO\nof\tO\nmetal\tO\nyou\tO\nget\tO\nthe\tO\njoy\tO\nof\tO\nspeaking\tO\nwith\tO\na\tO\nbunch\tO\nof\tO\npeople\tO\nyou\tO\nca\tO\nnt\tO\nunderstand\tO\n.\tO\n\nThat\tO\nday\tO\n!\tO\n\n\"\tO\nFor\tO\none\tO\n,\tO\nI\tO\nnoticed\tO\nthat\tO\nfrom\tO\nturning\tO\non\tO\nmy\tO\nmac\tO\nto\tO\nlogging\tO\non\tO\nonly\tO\ntook\tO\nabout\tO\n25\tO\nseconds\tO\n.\tO\n\nIt\tO\ndoes\tO\nnot\tO\neven\tO\nhave\tO\nthe\tO\nsoftware\tB-aspectTerm\nto\tO\nplay\tO\na\tO\ndvd\tO\nnow\tO\n.\tO\n\nMy\tO\nbrother\tO\nis\tO\na\tO\ncomputer\tO\nwiz\tO\nand\tO\nwould\tO\nlaugh\tO\nat\tO\nme\tO\nbecause\tO\nhe\tO\nused\tO\nan\tO\nApple\tO\n.\tO\n\nTech\tB-aspectTerm\nsupport\tI-aspectTerm\ntells\tO\nme\tO\nthe\tO\nlatter\tO\nproblem\tO\nis\tO\na\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nproblem\tO\nand\tO\nhave\tO\noffered\tO\nto\tO\nfix\tO\nit\tO\nif\tO\nit\tO\nhappens\tO\nagain\tO\n.\tO\n\nSince\tO\nI\tO\nnever\tO\nreally\tO\ngot\tO\nto\tO\nuse\tO\nthis\tO\n,\tO\nI\tO\nca\tO\nn't\tO\ncomment\tO\non\tO\nanything\tO\nexcept\tO\nwhat\tO\nwent\tO\nwrong\tO\nafter\tO\ntrying\tO\n2\tO\nof\tO\nthem\tO\n.\tO\n\nBuyers\tO\nbeware\tO\n.\tO\n\nHOW\tO\nDOES\tO\nTHE\tO\nPOWER\tB-aspectTerm\nSUPPLY\tI-aspectTerm\nNOT\tO\nWORK\tO\n!\tO\n!\tO\n!\tO\n\nSells\tO\nfor\tO\nthe\tO\nsame\tO\nas\tO\na\tO\nnetbook\tO\nwithout\tO\nsacrificing\tO\nsize\tB-aspectTerm\n.\tO\n\nI\tO\n'll\tO\nrather\tO\nbe\tO\nout\tO\nof\tO\ndate\tO\nthen\tO\nspend\tO\nmore\tO\nmoney\tO\non\tO\ntoshiba\tO\n.\tO\n\nupon\tO\ngiving\tO\nthem\tO\nthe\tO\nserial\tO\nnumber\tO\nthe\tO\nfirst\tO\nthing\tO\nI\tO\nwas\tO\ntold\tO\n,\tO\nwas\tO\nthat\tO\nit\tO\nwas\tO\nout\tO\nof\tO\nwarranty\tO\nand\tB-aspectTerm\nI\tO\ncould\tO\npay\tO\nto\tO\nhave\tO\nit\tO\nrepaired\tO\n.\tO\n\nWindows\tB-aspectTerm\nXP\tI-aspectTerm\nSP2\tI-aspectTerm\ncaused\tO\nmany\tO\nproblems\tO\non\tO\nthe\tO\ncomputer\tO\n,\tO\nso\tO\nI\tO\nhad\tO\nto\tO\nremove\tO\nit\tO\n.\tO\n\nLove\tO\nit\tO\n.\tO\n\nI\tO\nreloaded\tO\nwith\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nUltimate\tI-aspectTerm\n,\tO\nand\tO\nthe\tO\nBluetooth\tB-aspectTerm\nand\tO\nFingerprint\tB-aspectTerm\nreader\tI-aspectTerm\n(\tO\nsoftware\tB-aspectTerm\n)\tO\nwould\tO\nnot\tO\nload\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\ntechs\tB-aspectTerm\nat\tI-aspectTerm\nHP\tI-aspectTerm\nknew\tO\nwhat\tO\nthey\tO\nwere\tO\ndoing\tO\n.\tO\n\nOh\tO\n,\tO\nit\tO\nis\tO\nsuch\tO\na\tO\ngreat\tO\npiece\tO\nof\tO\nequipment\tO\n.\tO\n\nthis\tO\nis\tO\nmy\tO\nsecond\tO\none\tO\nand\tO\nthe\tO\nsame\tO\nproblem\tO\n,\tO\nbad\tO\nvideo\tB-aspectTerm\ncard\tI-aspectTerm\nunreliable\tO\noverall\tO\n,\tO\nthis\tO\nwill\tO\nbe\tO\nmy\tO\nsecond\tO\ntime\tO\nreturning\tO\nthis\tO\nlaptop\tO\nback\tO\nto\tO\nbest\tO\nbuy\tO\n.\tO\n\nI\tO\nuse\tO\nthat\tO\nalot\tO\non\tO\nmy\tO\ndesktop\tO\n,\tO\nso\tO\nI\tO\nam\tO\nadjusting\tO\nto\tO\nnot\tO\nhaving\tO\nit\tO\n.\tO\n\nWith\tO\nawesome\tO\ngraphics\tB-aspectTerm\nand\tO\nassuring\tO\nsecurity\tB-aspectTerm\n,\tO\nit\tO\n's\tO\nperfect\tO\n!\tO\n\nLaptop\tO\nwas\tO\nin\tO\nnew\tO\ncondition\tO\nand\tO\noperational\tO\n,\tO\nbut\tO\nfor\tO\nthe\tO\naudio\tB-aspectTerm\nproblem\tO\nwhen\tO\n1st\tO\nsent\tO\nfor\tO\nrepair\tO\n.\tO\n\nI\tO\nwas\tO\ndisappointed\tO\nwhen\tO\nI\tO\nrealized\tO\nthat\tO\nthe\tO\nkeyboard\tB-aspectTerm\ndoes\tO\nn't\tO\nlight\tO\nup\tO\non\tO\nthis\tO\nmodel\tO\n.\tO\n\nThis\tO\nmachine\tO\nwas\tO\na\tO\nhorrible\tO\nexperience\tO\n.\tO\n\nIt\tO\nruns\tB-aspectTerm\nperfectly\tO\n.\tO\n\nVery\tO\ndissappointed\tO\nbecase\tO\nI\tO\nhave\tO\nhad\tO\ntoshibas\tO\nfor\tO\nyears\tO\n,\tO\nand\tO\nnever\tO\na\tO\nissue\tO\n.\tO\n\nIf\tO\nyou\tO\nhave\tO\nany\tO\ncreativity\tO\nin\tO\nyou\tO\ndo\tO\nyourself\tO\na\tO\nfavor\tO\nand\tO\nget\tO\na\tO\nmac\tO\n!\tO\n\nThe\tO\nlaptop\tO\nwas\tO\nvery\tO\neasy\tO\nto\tO\nset\tB-aspectTerm\nup\tI-aspectTerm\n.\tO\n\nCongratulations\tO\nAsus\tO\nfor\tO\ncreating\tO\none\tO\nbig\tO\npiece\tO\nof\tO\ndump\tO\nwhich\tO\nis\tO\nmy\tO\nlaptop\tO\n.\tO\n\nSometimes\tO\nthe\tO\nscreen\tO\neven\tB-aspectTerm\ngoes\tO\nblack\tO\non\tO\nthis\tO\ncomputer\tO\n.\tO\n\nI\tO\nwould\tO\ndefinitely\tO\nrecommend\tO\nchecking\tO\nout\tO\nthis\tO\nlaptop\tO\nif\tO\nyou\tO\nare\tO\nin\tO\nthe\tO\nmarket\tO\nfor\tO\none\tO\n.\tO\n\nI\tO\nrecommend\tO\nfor\tO\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\nand\tO\ninternet\tB-aspectTerm\nusers\tO\n.\tO\n\nSince\tO\nI\tO\n've\tO\nhad\tO\nthis\tO\ncomputer\tO\nI\tO\n've\tO\nonly\tO\nused\tO\nthe\tO\ntrackpad\tB-aspectTerm\nbecause\tO\nit\tO\nis\tO\nso\tO\nnice\tO\nand\tO\nsmooth\tO\n.\tO\n\nWhen\tO\nthe\tO\ncomputer\tO\nhas\tO\nbeen\tO\non\tO\nfor\tO\nseveral\tO\nminutes\tO\n,\tO\nit\tO\nwill\tO\noccasionaly\tO\njust\tO\ngo\tO\noff\tO\nby\tO\nitself\tO\n.\tO\n\nA\tO\nlonger\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwould\tO\nhave\tO\nbeen\tO\ngreat\tO\n-\tO\nbut\tO\nit\tO\nmeets\tO\nit\tO\n's\tO\nspec\tB-aspectTerm\nquite\tO\neasily\tO\n.\tO\n\nWho\tO\ncould\tO\nn't\tO\nlove\tO\na\tO\nDVD\tB-aspectTerm\nburner\tI-aspectTerm\n,\tO\n80-gigabyte\tO\nHD\tB-aspectTerm\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tB-aspectTerm\nchip\tI-aspectTerm\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tO\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tO\nand\tO\nToshiba\tO\nmachines\tO\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tO\n-\tO\nquality\tO\ncomponents\tB-aspectTerm\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tO\n\nfalls\tO\ninto\tO\nthe\tO\ncase\tO\n.\tO\n\nThis\tO\nis\tO\nsomething\tO\ni\tO\nwould\tO\ndeffinately\tO\nreccomend\tO\nto\tO\nsomeone\tO\n.\tO\n\nIts\tO\nfast\tO\nand\tO\nanother\tO\nthing\tO\nI\tO\nlike\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\nthree\tO\nUSB\tB-aspectTerm\nports\tI-aspectTerm\n.\tO\n\nMac\tO\ncomputers\tO\nautomatically\tO\n\"\tO\ndefrag\tO\n\"\tO\neach\tO\ntime\tO\nyou\tO\nstart\tO\nyour\tO\ncomputer\tO\n.\tO\n\nThat\tO\nis\tO\nmy\tO\nonly\tO\ncomplaint\tO\n!\tO\n\nThe\tO\nsalesman\tO\ntalked\tO\nus\tO\ninto\tO\nthis\tO\ncomputer\tO\naway\tO\nfrom\tO\nanother\tO\nwe\tO\nwere\tO\nlooking\tO\nat\tO\nand\tO\nwe\tO\nhave\tO\nhad\tO\nnothing\tO\nbut\tO\nproblems\tO\nwith\tO\nsoftware\tB-aspectTerm\nproblems\tO\nand\tO\njust\tO\nnot\tO\nhappy\tO\nwith\tO\nit\tO\n.\tO\n\nThat\tO\nsystem\tB-aspectTerm\nis\tO\nfixed\tO\n.\tO\n\nThe\tO\ncomputer\tO\nitself\tO\nwas\tO\nfast\tO\n,\tO\nran\tB-aspectTerm\nsmoothly\tO\n,\tO\nand\tO\nhad\tO\nno\tO\nproblems\tO\n.\tO\n\nOne\tO\nof\tO\nthe\tO\nsmartest\tO\nthing\tO\nI\tO\ndid\tO\nwas\tO\ntake\tO\nmy\tO\ntime\tO\nto\tO\ncompare\tO\nlaptops\tO\nbefore\tO\nmaking\tO\nmy\tO\npurchase\tO\n.\tO\n\nLike\tO\nthe\tO\nprice\tB-aspectTerm\nand\tO\noperation\tB-aspectTerm\n.\tO\n\nThe\tO\nbrand\tB-aspectTerm\nis\tO\ntarnished\tO\nin\tO\nmy\tO\nheart\tO\n.\tO\n\nThis\tO\nis\tO\nlikely\tO\ndue\tO\nto\tO\npoor\tO\ngrounding\tO\nand\tO\nisolation\tO\nbetween\tO\nthe\tO\ncomponents\tB-aspectTerm\n,\tO\nand\tO\nI\tO\n'm\tO\nhoping\tO\nthat\tO\nit\tO\ncan\tO\nbe\tO\nfixed\tO\nwith\tO\na\tO\nground\tB-aspectTerm\nloop\tI-aspectTerm\nisolator\tI-aspectTerm\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tO\nbetter\tO\nproduct\tO\nquality\tB-aspectTerm\nfor\tO\nthis\tO\nprice\tB-aspectTerm\nrange\tI-aspectTerm\n.\tO\n\nHonestly\tO\n,\tO\nthis\tO\nis\tO\nabsolutely\tO\nwonderful\tO\n.\tO\n\nI\tO\n'\tO\nhave\tO\nhad\tO\nit\tO\nfor\tO\nabout\tO\na\tO\n1\tO\n1/2\tO\nand\tO\nyes\tO\nI\tO\nhave\tO\nhad\tO\nan\tO\nissue\tO\nwith\tO\nit\tO\none\tO\nmonth\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\n.\tO\n\nI\tO\nreally\tO\nwish\tO\nI\tO\nhad\tO\ndone\tO\nthis\tO\nyears\tO\nago\tO\n.\tO\n\nWell\tO\n,\tO\nmaybe\tO\nI\tO\nwas\tO\njust\tO\nvery\tO\nunlucky\tO\n.\tO\n\nFor\tO\nexample\tO\n,\tO\nwhen\tO\nmy\tO\nhusband\tO\nturns\tO\nthe\tO\nlight\tO\nout\tO\nwhile\tO\nI\tO\n'm\tO\non\tO\nthe\tO\ncomputer\tO\n.\tO\n\nOnce\tO\nopen\tO\n,\tO\nthe\tO\nleading\tB-aspectTerm\nedge\tI-aspectTerm\nis\tO\nrazor\tO\nsharp\tO\n.\tO\n\nLoaded\tO\nwith\tO\nbloatware\tB-aspectTerm\n.\tO\n\nIf\tO\nyou\tO\nbuy\tO\n,\tO\npray\tO\nyou\tO\ndo\tO\nnt\tO\nhave\tO\nmajor\tO\nprolems\tO\n.\tO\n\nDo\tO\nn't\tO\nget\tO\nme\tO\nwrong\tO\n,\tO\nI\tO\nam\tO\nno\tO\nMicrosoft\tO\nhater\tO\n,\tO\nI\tO\n've\tO\njust\tO\nmanaged\tO\nto\tO\nturn\tO\ninto\tO\na\tO\nmuch\tO\nbigger\tO\nApple\tO\nfan\tO\nbecause\tO\nof\tO\nthis\tO\nmachine\tO\n.\tO\n\nHP\tO\nrefused\tO\nto\tO\ngive\tO\nme\tO\na\tO\nnew\tO\none\tO\nand\tO\nWal\tO\nMart\tO\nrefused\tO\nto\tO\ntake\tO\nit\tO\nback\tO\n.\tO\n\nWithin\tO\n3\tO\nweeks\tO\nthe\tO\nsame\tO\nissues\tO\nstarted\tO\nhappening\tO\nAGAIN\tO\n.\tO\n\nMaximum\tB-aspectTerm\nsound\tI-aspectTerm\nis\tO\nn't\tO\nnearly\tO\nas\tO\nloud\tO\nas\tO\nit\tO\nshould\tO\nbe\tO\n.\tO\n\nWell\tO\n,\tO\nthey\tO\ndo\tO\nn't\tO\ncare\tO\na\tO\nbunch\tO\n.\tO\n\nI\tO\nloaded\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nvia\tO\nBootcamp\tB-aspectTerm\nand\tO\nit\tO\nworks\tO\nflawlessly\tO\n!\tO\n\nI\tO\nhave\tO\nnever\tO\nhad\tO\nto\tO\nshut\tO\ndown\tO\nthe\tO\ncomputer\tO\nunexpectedly\tO\nand\tO\nthe\tO\ncomputer\tO\nhas\tO\nnever\tO\nfroze\tO\non\tO\nme\tO\n.\tO\n\nGreat\tO\nLaptop\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n,\tO\nworks\tB-aspectTerm\nwell\tO\nwith\tO\naction\tB-aspectTerm\npack\tI-aspectTerm\ngames\tI-aspectTerm\n.\tO\n\nAlthough\tO\nthe\tO\nprice\tB-aspectTerm\nis\tO\nhigher\tO\nthen\tO\nDell\tO\nlaptops\tO\n,\tO\nthe\tO\nMacbooks\tO\nare\tO\nworth\tO\nthe\tO\ndough\tO\n.\tO\n\nRecommended\tO\nto\tO\npeople\tO\nas\tO\ntheir\tO\nfirst\tO\nlaptop\tO\n.\tO\n\nI\tO\nwould\tO\nrecomend\tO\nthis\tO\nacer\tO\nto\tO\nparents\tO\nand\tO\ngrandparents\tO\nit\tO\ncan\tO\nreally\tO\nhelp\tO\nthem\tO\nin\tO\nschool\tO\n.\tO\n\nI\tO\nwould\tO\nnot\tO\nrecommend\tO\nthis\tO\nto\tO\nanyone\tO\nwanting\tO\na\tO\nnotebook\tO\nexpecting\tO\nthe\tO\nperformance\tB-aspectTerm\nof\tO\na\tO\nDesktop\tO\nit\tO\ndoes\tO\nnot\tO\nmeet\tO\nthe\tO\nexpectations\tO\n.\tO\n\nThe\tO\nMacbook\tO\narrived\tO\nin\tO\na\tO\nnice\tO\ntwin\tB-aspectTerm\npacking\tI-aspectTerm\nand\tO\nsealed\tO\nin\tO\nthe\tO\nbox\tO\n,\tO\nall\tO\nthe\tO\nfunctions\tB-aspectTerm\nworks\tO\ngreat\tO\n.\tO\n\nSo\tO\nwhat\tO\nif\tO\nthe\tO\nlaptops\tO\n/\tO\nmobile\tO\nphones\tO\nlook\tB-aspectTerm\nchic\tO\nand\tO\ncool\tO\n?\tO\nThe\tO\nafter\tB-aspectTerm\nsales\tI-aspectTerm\nsupport\tI-aspectTerm\nis\tO\nterrible\tO\n.\tO\n\nthey\tO\nhave\tO\nnot\tO\nsent\tO\na\tO\nnew\tO\none\tO\nnor\tO\ncalled\tO\n.\tO\n\nI\tO\nwould\tO\neasly\tO\nreccomend\tO\nthis\tO\nlaptop\tO\nto\tO\na\tO\nfriend\tO\n.\tO\n\nI\tO\nhate\tO\nthe\tO\ndisplay\tB-aspectTerm\nscreen\tI-aspectTerm\nand\tO\nI\tO\nhave\tO\ndone\tO\neverything\tO\nI\tO\ncould\tO\ndo\tO\nthe\tO\nchange\tO\nit\tO\n.\tO\n\nI\tO\nspent\tO\nalot\tO\nof\tO\nmoney\tO\non\tO\nthis\tO\nproduct\tO\nand\tO\nits\tO\nbeen\tO\na\tO\nnightmare\tO\n.\tO\n\nI\tO\nalso\tO\nlike\tO\nthe\tO\nacer\tB-aspectTerm\narcade\tI-aspectTerm\nbut\tO\nthese\tO\nwere\tO\nreallythe\tO\nonly\tO\ntwo\tO\nthings\tO\nI\tO\nliked\tO\nabout\tO\nthis\tO\nlaptop\tO\n.\tO\n\nHave\tO\nnot\tO\nyet\tO\nneeded\tO\nany\tO\ncustomer\tB-aspectTerm\nsupport\tI-aspectTerm\nwith\tO\nthis\tO\nyet\tO\nso\tO\nto\tO\nme\tO\nthat\tO\nis\tO\na\tO\ngreat\tO\nthing\tO\n,\tO\nwhich\tO\nis\tO\nleaps\tO\nand\tO\nbounds\tO\nahead\tO\nof\tO\nPC\tO\nin\tO\nmy\tO\nopinion\tO\n.\tO\n\nThinking\tO\nabout\tO\nreturning\tO\nit\tO\n\nI\tO\ngave\tO\nit\tO\nto\tO\nmy\tO\ndaughter\tO\nbecause\tO\nI\tO\njust\tO\nhated\tO\nthe\tO\nscreen\tB-aspectTerm\n,\tO\nhated\tO\nthat\tO\nit\tO\nhad\tO\nno\tO\ncd\tB-aspectTerm\ndrive\tI-aspectTerm\nto\tO\nat\tO\nleast\tO\nplay\tO\ncd\tO\n's\tO\nwhen\tO\nI\tO\nwanted\tO\nto\tO\nlisten\tO\nto\tO\nmusic\tO\nand\tO\ndo\tO\nschoolwork\tO\n.\tO\n\nIt\tO\nruns\tB-aspectTerm\nvery\tO\nquiet\tO\ntoo\tO\nwhich\tO\nis\tO\na\tO\nplus\tO\n.\tO\n\nbut\tO\nit\tO\nhas\tO\na\tO\nmajor\tO\ndesign\tO\nflaw\tO\n.\tO\n\nI\tO\ntook\tO\nthe\tO\nlaptop\tO\nhome\tO\nand\tO\nnot\tO\neven\tO\na\tO\nmonth\tO\nlater\tO\n,\tO\nI\tO\nbegan\tO\nto\tO\nhave\tO\nproblems\tO\nwith\tO\nit\tO\n.\tO\n\nIt\tO\nwas\tO\nheavy\tO\n,\tO\nbulky\tO\n,\tO\nand\tO\nhard\tO\nto\tO\ncarry\tO\nbecause\tO\nof\tO\nthe\tO\nsize\tB-aspectTerm\n.\tO\n\nThat\tO\nwas\tO\nmy\tO\nfirst\tO\nApple\tO\nproduct\tO\nand\tO\nsince\tO\nthen\tO\nI\tO\nhave\tO\nbeen\tO\nincredibly\tO\nhappy\tO\nwith\tO\nevery\tO\nproduct\tO\nof\tO\ntheirs\tO\nI\tO\nhave\tO\nbought\tO\n.\tO\n\ni\tO\ntried\tO\nturning\tO\nit\tO\ndone\tO\nbut\tO\nit\tO\ndid\tO\nnothing\tO\n.\tO\n\nIt\tO\nis\tO\nsuper\tO\nfast\tO\n,\tO\nand\tO\nalways\tO\nloads\tO\n.\tO\n\nThe\tO\ngames\tB-aspectTerm\nincluded\tO\nare\tO\nvery\tO\ngood\tO\ngames\tB-aspectTerm\n.\tO\n\nthis\tO\ncomputer\tO\nwill\tO\nlast\tO\nyou\tO\nat\tO\nleast\tO\n7\tO\nyears\tO\n,\tO\nthat\tO\ns\tO\nan\tO\namazing\tO\nlife\tB-aspectTerm\nspanned\tO\nan\tO\nelectronic\tO\n.\tO\n\nI\tO\nbought\tO\nmine\tO\nfrom\tO\nApple\tO\nStore\tO\nthe\tO\nday\tO\nit\tO\nwas\tO\nreleased\tO\nas\tO\nAmazon\tO\ndid\tO\nn't\tO\nhave\tO\nit\tO\nyet\tO\n.\tO\n\nI\tO\nhad\tO\nsomething\tO\nelse\tO\ngo\tO\nwrong\tO\nand\tO\nthey\tO\nsaid\tO\nit\tO\nhad\tO\nto\tO\nbe\tO\nin\tO\ngood\tO\nworking\tO\norder\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nbuy\tO\nthe\tO\nwarranty\tB-aspectTerm\n.\tO\n\nthe\tO\nwhole\tO\nexperiece\tO\nis\tO\nhorrible\tO\nso\tO\nsave\tO\nup\tO\nand\tO\nbuy\tO\na\tO\nbetter\tO\nlaptop\tO\n.\tO\n\nI\tO\njust\tO\nbought\tO\nthis\tO\nlaptop\tO\n3\tO\ndays\tO\nago\tO\n.\tO\n\nI\tO\nam\tO\nvery\tO\npleased\tO\nwith\tO\nmy\tO\npurchase\tO\n!\tO\n\nSometimes\tO\nyou\tO\nreally\tO\nhave\tO\nto\tO\ntap\tO\nthe\tO\npad\tB-aspectTerm\nto\tO\nget\tO\nit\tO\nto\tO\nworki\tO\n\nIt\tO\n's\tO\nsuper\tO\nfast\tO\nand\tO\na\tO\ngreat\tO\nvalue\tB-aspectTerm\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n!\tO\n\nThree\tO\n,\tO\nthe\tO\nmac\tO\nbook\tO\nhas\tO\nadvantages\tO\nover\tO\npcs\tO\n'\tO\nwith\tO\nlinux\tB-aspectTerm\nbased\tI-aspectTerm\nos\tI-aspectTerm\nthere\tO\nis\tO\nvery\tO\n'\tO\nfew\tO\nproblems\tO\nwith\tO\nsystem\tB-aspectTerm\nperformance\tI-aspectTerm\nwhen\tO\nit\tO\ncomes\tO\nto\tO\na\tO\nmac\tO\n.\tO\n\nA\tO\nmac\tO\nis\tO\nvery\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nit\tO\nsimply\tO\nmakes\tO\nsense\tO\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\neMachines\tO\ncan\tO\nnot\tO\nbe\tO\nmade\tO\nentirely\tO\nto\tO\nblame\tO\nfor\tO\nthis\tO\ncomputer\tO\n's\tO\nwoes\tO\n;\tO\n\nhowever\tO\n,\tO\nI\tO\nmay\tO\nhave\tO\ninadvertently\tO\nthrown\tO\nout\tO\none\tO\nof\tO\nthe\tO\nbatteries\tB-aspectTerm\nwith\tO\nthe\tO\nshipping\tB-aspectTerm\ncarton\tI-aspectTerm\n.\tO\n\nLove\tO\nit\tO\nso\tO\nfar\tO\n.\tO\n\nIt\tO\nis\tO\nso\tO\nmuch\tO\neasier\tO\nto\tO\nuse\tB-aspectTerm\n\nThere\tO\nis\tO\nno\tO\nneed\tO\nto\tO\nopen\tO\na\tO\nprogram\tB-aspectTerm\nfirst\tO\nand\tO\nthe\tO\ncliick\tO\nopen\tO\nor\tO\nimport\tO\n.\tO\n\nIn\tO\nshort\tO\n,\tO\nyou\tO\ncould\tO\nsay\tO\nyour\tO\nmac\tO\ncould\tO\nbecome\tO\nyour\tO\nbest\tO\nfriend\tO\n(\tO\nno\tO\nintention\tO\nof\tO\nreplacing\tO\nRover\tO\nyour\tO\ndog\tO\n)\tO\n.\tO\n\nIt\tO\nwas\tO\na\tO\nbad\tO\nexperience\tO\nbut\tO\ni\tO\nplayed\tO\ndown\tO\nits\tO\nimportance\tO\n.\tO\n\nMeets\tO\nmy\tO\nneeds\tO\nperfectly\tO\nand\tO\nis\tO\nlight\tO\nenough\tO\nfor\tO\nthis\tO\nsenior\tO\nto\tO\ncarry\tO\nwithout\tO\naffecting\tO\nmy\tO\narthritis\tO\n.\tO\n\nIt\tO\nis\tO\nso\tO\nnice\tO\nnot\tO\nto\tO\nworry\tO\nabout\tO\nthat\tO\nand\tO\nthe\tO\nextra\tO\nexpense\tO\nthat\tO\ncomes\tO\nalong\tO\nwith\tO\nthe\tO\nnecessary\tO\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\non\tO\nPC\tO\n's\tO\n.\tO\n\nThe\tO\nNotebook\tO\nPC\tO\n,\tO\nToshiba\tO\nQosmio\tO\nis\tO\nthe\tO\nbest\tO\ngift\tO\nmy\tO\nfather\tO\ncould\tO\nhave\tO\never\tO\ngotten\tO\nme\tO\n.\tO\n\nThree\tO\nweeks\tO\nafter\tO\nI\tO\nbought\tO\nthe\tO\nnetbook\tO\n,\tO\nthe\tO\nscreen\tB-aspectTerm\nquit\tO\nworking\tO\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tO\nOSX\tB-aspectTerm\n16\tI-aspectTerm\nfunctions\tO\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tB-aspectTerm\nare\tO\nrouted\tO\nthrough\tO\nthe\tO\nhardware\tB-aspectTerm\nrather\tO\nthan\tO\nthe\tO\nsoftware\tB-aspectTerm\n.\tO\n\nI\tO\nam\tO\ncurrently\tO\nout\tO\nof\tO\ntown\tO\nand\tO\ncalled\tO\nto\tO\ninform\tO\nthem\tO\nthe\tO\nbroken\tO\npart\tO\nwould\tO\nbe\tO\nreturned\tO\nwhen\tO\nI\tO\ngot\tO\nback\tO\nin\tO\ntown\tO\n.\tO\n\nReturned\tO\nlaptop\tO\nfor\tO\na\tO\n4th\tO\nrepair\tO\nand\tO\nit\tO\ncame\tO\nback\tO\nbut\tO\nnow\tO\nwould\tO\nlock\tO\nup\tO\nand\tO\nrandomly\tO\nreboot\tO\nfrequently\tO\nmaking\tO\nthe\tO\nlaptop\tO\nunusable\tO\n.\tO\n\nI\tO\nwanted\tO\nsomething\tO\nthat\tO\nhad\tO\na\tO\nnew\tO\nIntel\tB-aspectTerm\nCore\tI-aspectTerm\nprocessors\tI-aspectTerm\nand\tO\nHDMI\tB-aspectTerm\nport\tI-aspectTerm\nso\tO\nthat\tO\nwe\tO\ncould\tO\nhook\tO\nit\tO\nup\tO\ndirectly\tO\nto\tO\nour\tO\nTV\tO\n.\tO\n\nThe\tO\nApple\tO\nwill\tO\nrun\tO\nInternet\tB-aspectTerm\nExplorer\tI-aspectTerm\n,\tO\nbut\tO\nat\tO\nan\tO\namazingly\tO\nslow\tO\nrate\tO\n.\tO\n\nWith\tO\ntoday\tO\n's\tO\ncompany\tO\nfighting\tO\nover\tO\nmarketshare\tO\n,\tO\nits\tO\na\tO\nshame\tO\nthat\tO\nASUS\tO\ncan\tO\nget\tO\naway\tO\nwith\tO\nthe\tO\ninept\tO\nstaff\tB-aspectTerm\nanswering\tO\nthephone\tO\n.\tO\n\nOther\tO\nthan\tO\nthat\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\none\tO\ncomplaint\tO\nin\tO\nthe\tO\nworld\tO\n!\tO\n\nThe\tO\ncomputer\tO\nis\tO\nso\tO\nslow\tO\n,\tO\neven\tO\nafter\tO\npaying\tO\nstaples\tO\nthe\tO\nextra\tO\nmoney\tO\nto\tO\nspeed\tO\nit\tO\nup\tO\n.\tO\n\nI\tO\nfeel\tO\nthat\tO\nenough\tO\npeople\tO\nhave\tO\nMacs\tO\nthese\tO\ndays\tO\nand\tO\nthat\tO\ncompanies\tO\nneed\tO\nto\tO\nstart\tO\nmaking\tO\nthings\tO\nmore\tO\ncompatable\tO\nthan\tO\nthey\tO\nused\tO\nto\tO\nbe\tO\n.\tO\n\nThe\tO\nprice\tB-aspectTerm\npremium\tI-aspectTerm\nis\tO\na\tO\nlittle\tO\nmuch\tO\n,\tO\nbut\tO\nwhen\tO\nyou\tO\nstart\tO\nlooking\tO\nat\tO\nthe\tO\nfeatures\tB-aspectTerm\nit\tO\nis\tO\nworth\tO\nthe\tO\nadded\tO\ncash\tO\n.\tO\n\n*\tO\n5\tO\nweeks\tO\nafter\tO\ngiving\tO\nthe\tO\ncomputer\tO\nfor\tO\nrepair*-Apple\tO\noffers\tO\nto\tO\nsend\tO\nreplacement\tO\nafter\tO\nthey\tO\nreceive\tO\nthe\tO\nold\tO\ncomputer\tO\n.\tO\n\nI\tO\nca\tO\nn't\tO\nsay\tO\nenough\tO\nof\tO\nhow\tO\nsatisfied\tO\nI\tO\nam\tO\nwith\tO\ntheir\tO\nproduct\tB-aspectTerm\nand\tI-aspectTerm\nhelp\tI-aspectTerm\naftermarket\tI-aspectTerm\n.\tO\n\nMy\tO\ncomputer\tO\nwas\tO\none\tO\nof\tO\nthe\tO\nbest\tO\nin\tO\nthe\tO\nschool\tO\ncompared\tO\nto\tO\nmy\tO\nfellow\tO\nclassmates\tO\n.\tO\n\nI\tO\nbought\tO\nfor\tO\nmy\tO\nson\tO\nin\tO\nthe\tO\n2nd\tO\ngrade\tO\n.\tO\n\nThis\tO\nhas\tO\nhappened\tO\nthree\tO\ntimes\tO\nso\tO\nfar\tO\n.\tO\n\nI\tO\n'm\tO\na\tO\nprofessional\tO\nconsultant\tO\n,\tO\nand\tO\na\tO\nclient\tO\nneeded\tO\nwork\tO\non\tO\nher\tO\nmachine\tO\n.\tO\n\ncompresses\tO\nitself\tO\nand\tO\nyou\tO\nca\tO\nn't\tO\nuse\tO\nit\tO\n.\tO\n\nMicrosoft\tB-aspectTerm\nword\tI-aspectTerm\nwas\tO\nnot\tO\non\tO\nit\tO\nandI\tO\nhad\tO\nto\tO\nbuy\tO\nit\tO\nseperately\tO\n.\tO\n\nit\tO\nhas\tO\n3\tO\nusb\tB-aspectTerm\nports\tI-aspectTerm\n,\tO\n1\tO\nsd\tB-aspectTerm\nmemory\tI-aspectTerm\ncard\tI-aspectTerm\nreader\tI-aspectTerm\nand\tO\nan\tO\nsd\tB-aspectTerm\nmemory\tI-aspectTerm\ncar\tI-aspectTerm\nexpansion\tI-aspectTerm\n.\tO\n\nWho\tO\nknows\tO\nwhat\tO\nwill\tO\nhappen\tO\nlater\tO\non\tO\nwhen\tO\nthey\tO\ndismantle\tO\nthe\tO\nwhole\tO\ndamn\tO\nthing\tO\n?\tO\nSo\tO\n,\tO\nI\tO\nsaid\tO\nI\tO\nwanted\tO\na\tO\nnew\tO\nset\tO\n.\tO\n\nI\tO\nconnect\tO\na\tO\nLaCie\tB-aspectTerm\n2Big\tI-aspectTerm\nexternal\tI-aspectTerm\ndrive\tI-aspectTerm\nvia\tO\nthe\tO\nfirewire\tB-aspectTerm\n800\tI-aspectTerm\ninterface\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\nuseful\tO\nfor\tO\nTime\tB-aspectTerm\nMachine\tI-aspectTerm\n.\tO\n\nIf\tO\nyou\tO\nalready\tO\nown\tO\na\tO\n2009\tO\n,\tO\n2010\tO\n,\tO\nor\tO\nearly\tO\n2011\tO\nmodel\tO\n,\tO\nyou\tO\nshould\tO\nwait\tO\nuntil\tO\nthe\tO\nnext\tO\nupdate\tO\n.\tO\n\nMy\tO\nToshiba\tO\ndid\tO\nnot\tO\nhave\tO\nsound\tB-aspectTerm\non\tO\neverything\tO\n,\tO\njust\tO\ncertain\tO\nthings\tO\n.\tO\n\nI\tO\nam\tO\noverall\tO\nvery\tO\npleased\tO\nwith\tO\nmy\tO\ntoshiba\tO\nsatellite\tO\n,\tO\nI\tO\nlike\tO\nthe\tO\nextra\tB-aspectTerm\nfeatures\tI-aspectTerm\n,\tO\nI\tO\nlove\tO\nthe\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nhome\tI-aspectTerm\npremium\tI-aspectTerm\n.\tO\n\nSo\tO\n,\tO\nI\tO\nmust\tO\nsay\tO\nI\tO\nam\tO\nnot\tO\na\tO\nhappy\tO\ncamper\tO\n.\tO\n\n-Called\tO\nMacHouse\tO\nAmsterdam\tO\nto\tO\nask\tO\nfor\tO\na\tO\ntemporary\tO\nreplacement\tO\n,\tO\nno\tO\nanswer\tO\n.\tO\n\nThe\tO\nAspire\tO\nwo\tO\nnt\tO\neven\tO\nboot\tB-aspectTerm\npast\tO\nthe\tO\nAcer\tB-aspectTerm\nscreen\tI-aspectTerm\nwith\tO\na\tO\nDroid\tO\n(\tO\nI\tO\nhave\tO\ntried\tO\nboth\tO\nMotorola\tO\nand\tO\nHTC\tO\n)\tO\nplugged\tO\ninto\tO\nthe\tO\nUSB\tB-aspectTerm\nport\tI-aspectTerm\n.\tO\n\nI\tO\nbought\tO\nit\tO\nduring\tO\nthe\tO\nrecent\tO\nComex\tO\nIT\tO\nshow\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwas\tO\nshorter\tO\nthan\tO\nexpected\tO\n.\tO\n\nIt\tO\nfires\tB-aspectTerm\nup\tI-aspectTerm\nin\tO\nthe\tO\nmorning\tO\nin\tO\nless\tO\nthan\tO\n30\tO\nseconds\tO\nand\tO\nI\tO\nhave\tO\nnever\tO\nhad\tO\nany\tO\nissues\tO\nwith\tO\nit\tO\nfreezing\tO\n.\tO\n\nIt\tO\ndoes\tO\nnt\tO\noverheat\tO\nor\tO\nmake\tO\nany\tO\nloud\tO\nnoises\tO\n.\tO\n\nLook\tO\nup\tO\nrecipes\tO\nand\tO\nkeep\tO\nit\tO\non\tO\nthe\tO\nkitchen\tO\ncounter\tO\nwhile\tO\nI\tO\ncook\tO\n.\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\nis\tO\ntop\tO\nnotch\tO\n.\tO\n\nDo\tO\nyou\tO\nthink\tO\nthe\tO\nshop\tO\nwill\tO\ngive\tO\nme\tO\na\tO\nnew\tO\nset\tO\n?\tO\n?\tO\nIt\tO\nwill\tO\nNOT\tO\n!\tO\n\nI\tO\nhave\tO\nhad\tO\nnothing\tO\nbut\tO\nproblems\tO\nsince\tO\nthe\tO\nday\tO\nI\tO\ntook\tO\nit\tO\nout\tO\nof\tO\nthe\tO\nbox\tO\n!\tO\n\nMy\tO\nMacbook\tO\nwas\tO\nworth\tO\n(\tO\nafter\tO\n3\tO\nyears\tO\nof\tO\nuse\tO\n!\tO\n)\tO\n$\tO\n375\tO\n.\tO\n\nIt\tO\ndrives\tO\nme\tO\ncrazy\tO\nwhen\tO\nI\tO\nwant\tO\nto\tO\ndownload\tO\na\tO\ngame\tO\nor\tO\nsomething\tO\nof\tO\nthat\tO\nnature\tO\nand\tO\nI\tO\nca\tO\nn't\tO\nplay\tO\nit\tO\nbecause\tO\nits\tO\nnot\tO\ncompatable\tO\nwith\tO\nthe\tO\nsoftware\tB-aspectTerm\n.\tO\n\nThe\tO\nonline\tB-aspectTerm\ntutorial\tI-aspectTerm\nvideos\tI-aspectTerm\nmake\tO\nit\tO\nsuper\tO\neasy\tO\nto\tO\nlearn\tO\nif\tO\nyou\tO\nhave\tO\nalways\tO\nused\tO\na\tO\nPC\tO\n.\tO\n\nBought\tO\nthis\tO\ngateway\tO\nM-50\tO\nor\tO\n150\tO\nearly\tO\n2007\tO\n.\tO\n\nThe\tO\nimage\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nand\tO\nthe\tO\nsoud\tB-aspectTerm\nis\tO\nexcelent\tO\n.\tO\n\nWith\tO\na\tO\nMAC\tO\ncomputer\tO\nI\tO\nhave\tO\nmore\tO\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nwait\tO\nfor\tO\nwindows\tB-aspectTerm\nto\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nor\tO\nshut\tB-aspectTerm\ndown\tI-aspectTerm\nand\tO\nall\tO\nthe\tO\nviruses\tO\nassociated\tO\nwith\tO\nwindows\tB-aspectTerm\n.\tO\n\nIt\tO\nwas\tO\nvery\tO\neasy\tO\nto\tO\njust\tO\npick\tO\nup\tO\nand\tO\nuse--\tB-aspectTerm\nIt\tO\ndid\tO\nnot\tO\ntake\tO\nlong\tO\nto\tO\nget\tO\nused\tO\nto\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\n.\tO\n\nThis\tO\nnetbook\tO\nis\tO\na\tO\nperfect\tO\nsupplementary\tO\ncomputer\tO\nto\tO\nanother\tO\nlaptop\tO\nor\tO\ndesktop\tO\n(\tO\nmy\tO\nwife\tO\nand\tO\nI\tO\nhave\tO\nanother\tO\nlaptop\tO\n)\tO\n,\tO\nor\tO\nif\tO\nyou\tO\nare\tO\na\tO\nuser\tO\nwho\tO\nuses\tO\nthe\tO\ncomputer\tO\nfor\tO\nsimple\tO\ntasks\tO\n.\tO\n\nWith\tO\nall\tO\nthe\tO\ngoodies\tO\ninside\tO\nthis\tO\nmachine\tO\n,\tO\nit\tO\nis\tO\na\tO\nvalue\tO\n.\tO\n\nI\tO\ntook\tO\nit\tO\nback\tO\nfor\tO\na\tO\nfull\tO\nrefund\tO\n.\tO\n\nIt\tO\nis\tO\nwell\tO\nworth\tO\nthe\tO\nmoney\tO\nit\tO\ncost\tB-aspectTerm\n,\tO\nVery\tO\ngood\tO\ninvestment\tO\n.\tO\n\nUpgrading\tO\nfrom\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nStarter\tI-aspectTerm\n,\tO\nthru\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nHome\tI-aspectTerm\nPremium\tI-aspectTerm\n,\tO\nto\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nProfessional\tI-aspectTerm\nwas\tO\na\tO\nsnap\tO\n;\tO\n\nThis\tO\ncomputer\tO\nhad\tO\nexactly\tO\nthe\tO\nspecifications\tB-aspectTerm\nI\tO\nneeded\tO\n.\tO\n\nOverall\tO\n,\tO\nstill\tO\na\tO\nvery\tO\nnice\tO\nmachine\tO\n.\tO\n\nWhere\tO\nyou\tO\nclick\tO\nand\tO\nhold\tO\nand\tO\ndrag\tO\nit\tO\npicture\tO\n,\tO\nlink\tO\n,\tO\netc\tO\nto\tO\nwhere\tO\nyou\tO\nwant\tO\nit\tO\n.\tO\n\nMy\tO\nkids\tO\n(\tO\nand\tO\ndogs\tO\n)\tO\ndestroyed\tO\ntwo\tO\npower\tB-aspectTerm\ncords\tI-aspectTerm\nby\tO\npulling\tO\non\tO\nthem\tO\n.\tO\n\nI\tO\nhad\tO\nupgraded\tO\nmy\tO\nold\tO\nMacBook\tO\nto\tO\nLion\tO\n,\tO\nso\tO\nI\tO\nkind\tO\nof\tO\nknew\tO\nwhat\tO\nI\tO\nwas\tO\ngetting\tO\n,\tO\nbut\tO\nhad\tO\nn't\tO\nbeen\tO\nable\tO\nto\tO\nenjoy\tO\nsome\tO\nof\tO\nthe\tO\nawesome\tO\nnew\tO\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\nfeatures\tI-aspectTerm\n.\tO\n\nI\tO\nhad\tO\nthis\tO\ncomputer\tO\nfor\tO\none\tO\nmonth\tO\nand\tO\nhad\tO\nto\tO\nsend\tO\nit\tO\nin\tO\nfor\tO\nrepair\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\na\tO\nlittle\tO\nglary\tO\n,\tO\nand\tO\nI\tO\nhated\tO\nthe\tO\nclicking\tB-aspectTerm\nbuttons\tI-aspectTerm\n,\tO\nbut\tO\nI\tO\ngot\tO\nused\tO\nto\tO\nthem\tO\n.\tO\n\nNot\tO\nto\tO\nmention\tO\n,\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nabsolutely\tO\namazing\tO\n.\tO\n\nI\tO\nrealize\tO\nthat\tO\nnot\tO\nevery\tO\nunit\tO\nhas\tO\nthis\tO\nissue\tO\n,\tO\nbut\tO\nthe\tO\nones\tO\nthat\tO\ndo\tO\ncan\tO\nnot\tO\nbe\tO\nrepaired\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\na\tO\nMac\tO\nfor\tO\n6\tO\nyears\tO\nand\tO\nwo\tO\nn't\tO\ngo\tO\nback\tO\nto\tO\nPC\tO\n.\tO\n\ni\tO\nlove\tO\nto\tO\nuse\tO\nit\tO\nit\tO\nis\tO\nesay\tO\nand\tO\nlight\tO\n.\tO\n\nWindows\tB-aspectTerm\nalso\tO\nshuts\tO\nthe\tO\ncomputer\tO\ndown\tO\nfor\tO\nno\tO\nreason\tO\nwithout\tO\nwarning\tO\n.\tO\n\nnot\tO\nusing\tO\nwired\tB-aspectTerm\nlan\tI-aspectTerm\nnot\tO\nsure\tO\nwhat\tO\nthat\tO\ns\tO\nabout\tO\n.\tO\n\nAfter\tO\nabout\tO\nanother\tO\nmonth\tO\nI\tO\nhad\tO\nto\tO\nsend\tO\nit\tO\nin\tO\nAGAIN\tO\nto\tO\nAcer\tO\nfor\tO\nrepairs\tO\n.\tO\n\nThe\tO\nmacbook\tO\nrarely\tO\nrequires\tO\na\tO\nhard\tB-aspectTerm\nreboot\tI-aspectTerm\n.\tO\n\nI\tO\nLOVE\tO\nit\tO\n!\tO\n\nThe\tO\n#\tO\n1\tO\nreason\tO\nthat\tO\nis\tO\nalways\tO\nrepeated\tO\n.\tO\n\nNow\tO\nfor\tO\nthe\tO\nhardware\tB-aspectTerm\nproblems\tO\n.\tO\n\nUnfortunately\tO\n,\tO\nthat\tO\nis\tO\nnot\tO\nthe\tO\ncase\tO\n.\tO\n\nAnyways\tO\nI\tO\nbought\tO\nthis\tO\ntwo\tO\nmonths\tO\nago\tO\nand\tO\nwhen\tO\nI\tO\nfirst\tO\nbrought\tO\nit\tO\nhome\tO\nit\tO\nkept\tO\ngiving\tO\nme\tO\na\tO\nmessage\tO\nabout\tO\na\tO\nvibration\tO\nin\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nit\tO\nis\tO\nputting\tO\nit\tO\ntemporaly\tO\nin\tO\nsave\tO\nzone\tO\n.\tO\n\nIt\tO\n's\tO\nfast\tO\nand\tO\nhas\tO\nexcellent\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nface\tO\nand\tO\ndepanable\tO\n.\tO\n\nNo\tO\nViruses\tO\n!\tO\n\nI\tO\n'm\tO\njust\tO\nreally\tO\nhappy\tO\nthat\tO\nI\tO\nwaited\tO\nto\tO\nbuy\tO\n,\tO\nbecause\tO\nthis\tO\nthing\tO\nkicks\tO\na$$\tO\n!\tO\n\nThe\tO\nHewitt\tO\nPackard\tO\nPavillion\tO\ndv6700\tO\nwas\tO\nmy\tO\nfirst\tO\nlaptop\tO\n,\tO\nbefore\tO\nthis\tO\nI\tO\nhad\tO\na\tO\nDell\tO\ndesktop\tO\nthat\tO\nI\tO\nloved\tO\n.\tO\n\nApple\tB-aspectTerm\ncare\tI-aspectTerm\nincluded\tO\n.\tO\n\nIt\tO\nwas\tO\nan\tO\nall\tO\naround\tO\nwaste\tO\nof\tO\nmoney\tO\nfor\tO\nme\tO\n.\tO\n\nI\tO\nworked\tO\nin\tO\nIT\tO\nretail\tO\nsales\tO\nbefore\tO\n.\tO\n\nFeatures\tB-aspectTerm\nlike\tO\nthe\tO\nfont\tB-aspectTerm\nare\tO\nvery\tO\nblock\tO\n-\tO\nlike\tO\nand\tO\nold\tO\nschool\tO\n.\tO\n\nIt\tO\nhas\tO\neverything\tO\nyou\tO\nneed\tO\nto\tO\nget\tO\nthe\tO\njob\tO\ndone\tO\n.\tO\n\nIt\tO\nis\tO\nloaded\tO\nwith\tO\nprograms\tB-aspectTerm\nthat\tO\nis\tO\nof\tO\nno\tO\ngood\tO\nfor\tO\nthe\tO\naverage\tO\nuser\tO\n,\tO\nthat\tO\nmakes\tO\nit\tO\nrun\tB-aspectTerm\nway\tO\nto\tO\nslow\tO\n.\tO\n\nI\tO\nfeel\tO\nthat\tO\nit\tO\nwas\tO\npoorly\tO\nput\tO\ntogether\tO\n,\tO\nbecause\tO\nonce\tO\nin\tO\na\tO\nwhile\tO\ndifferent\tO\nplastic\tB-aspectTerm\npieces\tI-aspectTerm\nwould\tO\ncome\tO\noff\tO\nof\tO\nit\tO\n.\tO\n\nit\tO\nca\tO\nnt\tO\nfuction\tO\nwell\tO\nwith\tO\nlots\tO\nof\tO\nwebpages\tO\nopen\tO\nat\tO\nonce\tO\n.\tO\n\nFinally\tO\n,\tO\nI\tO\nshould\tO\nnote\tO\nthat\tO\nI\tO\ntook\tO\nthe\tO\n2\tB-aspectTerm\nGB\tI-aspectTerm\nRAM\tI-aspectTerm\nstick\tI-aspectTerm\nfrom\tO\nmy\tO\nold\tO\nEeePC\tO\nand\tO\ninstalled\tO\nit\tO\nbefore\tO\nI\tO\neven\tO\npowered\tO\non\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\n.\tO\n\nThis\tO\nlaptop\tO\nhas\tO\nleft\tO\nme\tO\nwith\tO\na\tO\nHORRIBLE\tO\ntaste\tO\nin\tO\nmy\tO\nmouth\tO\nfor\tO\nAcer\tO\nbrand\tO\nproducts\tO\n.\tO\n\nits\tO\nnot\tO\nbad\tO\njust\tO\nVERY\tO\nVERY\tO\nannoying\tO\n.\tO\n\nWell\tO\n,\tO\nmaybe\tO\nmore\tO\nlike\tO\nweek\tO\none\tO\n.\tO\n\nWindows\tB-aspectTerm\nis\tO\nalso\tO\nrather\tO\nunsteady\tO\non\tO\nits\tO\nfeet\tO\nand\tO\nis\tO\nsusceptible\tO\nto\tO\nmany\tO\nbugs\tO\n.\tO\n\nAfter\tO\nsending\tO\nout\tO\ndocuments\tO\nvia\tO\nemail\tO\nand\tO\nhaving\tO\nrecipients\tO\ntell\tO\nme\tO\nthey\tO\ncould\tO\nnot\tO\nopen\tO\nthe\tO\ndocuments\tO\nor\tO\nthey\tO\ncame\tO\nthrough\tO\nas\tO\ngibberish\tO\n,\tO\nI\tO\nbroke\tO\ndown\tO\nand\tO\nspent\tO\nanother\tO\n$\tO\n100\tO\nto\tO\nget\tO\nMicrosoft\tB-aspectTerm\nWord\tI-aspectTerm\nfor\tI-aspectTerm\nMac\tI-aspectTerm\n.\tO\n\nI\tO\nbelieve\tO\nI\tO\npurchased\tO\nthis\tO\nin\tO\nDec\tO\n09\tO\nfor\tO\nmy\tO\nprimary\tO\nwork\tO\nlaptop\tO\nwhich\tO\nis\tO\nused\tO\n5\tO\n-\tO\n10\tO\nhours\tO\na\tO\nday\tO\n,\tO\n4\tO\n-\tO\n6\tO\ndays\tO\na\tO\nweek\tO\n.\tO\n\nDO\tO\nNOT\tO\nBUY\tO\nGATEWAY\tO\nCOMPUTERS\tO\nTHEY\tO\nARE\tO\nJUNK\tO\nAND\tO\nTHE\tO\nWARRANTY\tB-aspectTerm\nCOMPANY\tI-aspectTerm\nIS\tO\nHORRIBLE\tO\n.\tO\n\nthen\tO\non\tO\ntop\tO\nof\tO\nit\tO\nall\tO\ntheir\tO\ncusromer\tB-aspectTerm\nservice\tI-aspectTerm\ncenter\tI-aspectTerm\nis\tO\nin\tO\nthe\tO\nmiddle\tO\neast\tO\n.\tO\n\nThe\tO\nonly\tO\nbad\tO\npart\tO\nis\tO\nthe\tO\nsize\tB-aspectTerm\n/\tO\nweight\tB-aspectTerm\n.\tO\n\nThe\tO\nlittle\tO\nbattery\tB-aspectTerm\nthat\tO\nit\tO\ndid\tO\nhave\tO\nwould\tO\nonly\tO\nlast\tO\nabout\tO\nan\tO\nhour\tO\nwhile\tO\njust\tO\nhaving\tO\nit\tO\non\tO\nthe\tO\ndesktop\tO\n.\tO\n\nI\tO\nliked\tO\nthe\tO\naluminum\tB-aspectTerm\nbody\tI-aspectTerm\n.\tO\n\nalso\tO\nit\tO\nis\tO\nlight\tO\nweight\tO\ncompared\tO\nto\tO\nothers\tO\n.\tO\n\nIts\tO\ngood\tO\nfor\tO\nplaying\tB-aspectTerm\nmy\tO\napps\tO\non\tO\nFacebook\tO\nor\tO\nwatching\tB-aspectTerm\nmovies\tI-aspectTerm\n.\tO\n\nFrom\tO\nthe\tO\nbuild\tB-aspectTerm\nquality\tI-aspectTerm\nto\tO\nthe\tO\nperformance\tB-aspectTerm\n,\tO\neverything\tO\nabout\tO\nit\tO\nhas\tO\nbeen\tO\nsub\tO\n-\tO\npar\tO\nfrom\tO\nwhat\tO\nI\tO\nwould\tO\nhave\tO\nexpected\tO\nfrom\tO\nApple\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\ndock\tB-aspectTerm\nwhere\tO\nI\tO\ncan\tO\nsimply\tO\ndrop\tO\na\tO\nfile\tO\nontop\tO\nof\tO\na\tO\nparticular\tO\nprogram\tB-aspectTerm\n,\tO\nand\tO\nthe\tO\nprogram\tB-aspectTerm\nwill\tO\nsimply\tO\nopen\tO\nthat\tO\nfile\tO\n.\tO\n\nSorry\tO\n,\tO\nnewegg\tO\n.\tO\n\nBe\tO\nsafe\tO\nbuy\tO\na\tO\nSony\tO\n.\tO\n\npretty\tO\nmuch\tO\neverything\tO\nelse\tO\nabout\tO\nthe\tO\ncomputer\tO\nis\tO\ngood\tO\nit\tO\njust\tO\nstops\tO\nworking\tB-aspectTerm\nout\tO\nof\tO\nno\tO\nwere\tO\n.\tO\n\nOriginally\tO\nbought\tO\nit\tO\nfor\tO\nmy\tO\nwife\tO\n.\tO\n\nIt\tO\nwas\tO\ntruly\tO\na\tO\ngreat\tO\ncomputer\tO\ncosting\tB-aspectTerm\nless\tO\nthan\tO\none\tO\nthousand\tO\nbucks\tO\nbefore\tO\ntax\tO\n.\tO\n\nWaiting\tO\nfor\tO\nthe\tO\ni7\tB-aspectTerm\nwas\tO\nwell\tO\nworth\tO\nit\tO\n,\tO\ngreat\tO\nvalue\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\non\tO\nSaturday\tO\nand\tO\nam\tO\ncompletely\tO\nin\tO\nlove\tO\nwith\tO\nit\tO\n!\tO\n\nI\tO\nasked\tO\nhow\tO\nthey\tO\nwould\tO\ndetermine\tO\nthat\tO\nsince\tO\nthere\tO\nare\tO\nno\tO\nscratches\tO\n,\tO\ndents\tO\nor\tO\nother\tO\nsigns\tO\nof\tO\ndamage\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nwas\tO\nthe\tO\nonly\tO\nway\tO\nthis\tO\ntype\tO\nof\tO\ndamage\tO\ncould\tO\nhappen\tO\n.\tO\n\nNow,,,,,my\tO\nmonitor\tB-aspectTerm\nhas\tO\nbeen\tO\nacting\tO\nup\tO\nfor\tO\nabout\tO\n2\tO\nmonths\tO\n.\tO\n\nAlso\tO\n,\tO\nthe\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\nwas\tO\na\tO\nproblem\tO\n.\tO\n\nBoots\tB-aspectTerm\nup\tI-aspectTerm\nfast\tO\nand\tO\nruns\tB-aspectTerm\ngreat\tO\n!\tO\n\nLightweight\tO\nand\tO\nthe\tO\nscreen\tB-aspectTerm\nis\tO\nbeautiful\tO\n!\tO\n\nBuy\tO\nit\tO\n,\tO\nlove\tO\nit\tO\n,\tO\nand\tO\nI\tO\npromise\tO\nyou\tO\nwo\tO\nn't\tO\nregret\tO\nit\tO\n.\tO\n\nI\tO\nneeded\tO\na\tO\ndriver\tB-aspectTerm\nfor\tO\nmy\tO\nHP\tO\nand\tO\nthey\tO\nwould\tO\nnot\tO\nhelp\tO\nme\tO\nwith\tO\nout\tO\nme\tO\npaying\tO\nover\tO\n$\tO\n50\tO\nfor\tO\nit\tO\n.\tO\n\nIf\tO\nyou\tO\ndo\tO\nn't\tO\nlike\tO\nfingerprints\tO\n,\tO\nthis\tO\nmight\tO\nnot\tO\nbe\tO\nthe\tO\nlaptop\tO\nfor\tO\nyou\tO\n.\tO\n\nCall\tO\ntech\tB-aspectTerm\nsupport\tI-aspectTerm\n,\tO\nstandard\tO\nemail\tO\nthe\tO\nform\tO\nand\tO\nfax\tO\nit\tO\nback\tO\nin\tO\nto\tO\nus\tO\n.\tO\n\nJust\tO\na\tO\nmonth\tO\nand\tO\na\tO\nhalf\tO\nor\tO\ntwo\tO\nmonths\tO\nago\tO\n,\tO\nmy\tO\nVAIO\tO\ncrashed\tO\nagain\tO\n.\tO\n\nThey\tO\nsent\tO\nit\tO\nback\tO\nwith\tO\na\tO\nhuge\tO\ncrack\tO\nin\tO\nit\tO\nand\tO\nit\tO\nstill\tO\ndid\tO\nn't\tO\nwork\tB-aspectTerm\n.\tO\n\nA\tO\ncoupla\tO\nmonths\tO\nlater\tO\n,\tO\nthey\tO\nchange\tO\nmy\tO\nhard\tO\ndrive\tB-aspectTerm\n.\tI-aspectTerm\n\nI\tO\ndid\tO\ncontact\tO\nHP\tO\nand\tO\nshare\tO\nhow\tO\nunhappy\tO\nI\tO\nam\tO\n.\tO\n\nThe\tO\nMacbook\tO\narrived\tO\nin\tO\na\tO\nnice\tO\ntwin\tB-aspectTerm\npacking\tI-aspectTerm\nand\tO\nsealed\tO\nin\tO\nthe\tO\nbox\tO\n,\tO\nall\tO\nthe\tO\nfunctions\tB-aspectTerm\nworks\tO\ngreat\tO\n.\tO\n\nThe\tO\n13\tO\n\"\tO\nMacBook\tO\nPro\tO\nis\tO\nportable\tO\n,\tO\ndurable\tO\n,\tO\nand\tO\nvery\tO\ncapable\tO\n.\tO\n\nI\tO\nshould\tO\nhave\tO\nspent\tO\nan\tO\nextra\tO\nhundred\tO\nbucks\tO\nand\tO\ngot\tO\na\tO\nfull\tO\nsized\tO\ncomputer\tO\n.\tO\n\nGreat\tO\noverall\tO\n.\tO\n\nMy\tO\nsmart\tO\nphone\tO\nis\tO\nfaster\tO\n!\tO\n\nThey\tO\nsay\tO\nsorry\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\n.\tO\n\nI\tO\nhave\tO\nfull\tO\ncontrol\tO\nat\tO\nall\tO\ntimes\tO\nof\tO\nwhat\tO\nis\tO\ngoing\tO\non\tO\n-\tO\nthere\tO\nis\tO\nno\tO\ncontrol+alt+delete\tO\nbusiness\tO\nanymore\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\nbecause\tO\nof\tO\nthe\tO\nperformance\tB-aspectTerm\nto\tO\nprice\tB-aspectTerm\nratio\tO\n.\tO\n\nPC\tO\nnever\tO\nworked\tO\nright\tO\neven\tO\nafter\tO\nBIOS\tB-aspectTerm\nfixed\tO\n.\tO\n\nAfter\tO\nhaving\tO\ntwo\tO\nPC\tO\nlaptops\tO\ndie\tO\nwith\tO\nin\tO\nthe\tO\npast\tO\n3\tO\nyears\tO\n,\tO\nI\tO\nwas\tO\nled\tO\nto\tO\nthe\tO\nApple\tO\ndisplay\tO\nat\tO\nBest\tO\nBuy\tO\nby\tO\nthe\tO\nsleek\tO\ndesign\tB-aspectTerm\nand\tO\npromise\tO\nof\tO\nless\tO\ntech\tB-aspectTerm\nissues\tI-aspectTerm\n.\tO\n\nI\tO\nhave\tO\na\tO\nlaptop\tO\nas\tO\nmy\tO\nregular\tO\ncomputer\tO\n,\tO\nbut\tO\nfound\tO\nthat\tO\ndisconnecting\tO\nit\tO\nand\tO\nlugging\tO\nit\tO\naround\tO\nwas\tO\na\tO\ndrag\tO\n.\tO\n\nThis\tO\nis\tO\nmy\tO\nsecond\tO\nMacBook\tO\n.\tO\n\nThe\tO\nsize\tB-aspectTerm\nis\tO\nperfect\tO\nand\tO\nI\tO\ndo\tO\nnot\tO\nrecomend\tO\nanything\tO\nbigger\tO\nexcept\tO\nfor\tO\nany\tO\nperson\tO\nwho\tO\ncan\tO\nexceed\tO\nthe\tO\nlimited\tO\nspace\tB-aspectTerm\nit\tO\ngives\tO\nyou\tO\n.\tO\n\nThe\tO\nservice\tB-aspectTerm\nI\tO\nreceived\tO\nfrom\tO\nToshiba\tO\nwent\tO\nabove\tO\nand\tO\nbeyond\tO\nthe\tO\ncall\tO\nof\tO\nduty\tO\n.\tO\n\nHave\tO\nhad\tO\nmany\tO\nhigher\tO\npriced\tB-aspectTerm\ncomputers\tO\ncrash\tO\nand\tO\nburn\tO\nlong\tO\nbefore\tO\never\tO\ngot\tO\nto\tO\nuse\tO\nall\tO\nthat\tO\ngreat\tO\nmemory\tB-aspectTerm\nand\tO\nspeed\tB-aspectTerm\n,\tO\netc\tO\n.\tO\n\nI\tO\nwould\tO\nrecommend\tO\nit\tO\njust\tO\nbecause\tO\nof\tO\nthe\tO\ninternet\tB-aspectTerm\nspeed\tI-aspectTerm\nprobably\tO\nbecause\tO\nthat\tO\ns\tO\nthe\tO\nonly\tO\nthing\tO\ni\tO\nreally\tO\ncare\tO\nabout\tO\n.\tO\n\nI\tO\nown\tO\nother\tO\nMacs\tO\nbut\tO\nalways\tO\nfind\tO\nmyself\tO\nnavigation\tO\nto\tO\nthe\tO\nMacBook\tO\nPro\tO\nto\tO\nget\tO\nmy\tO\nwork\tO\ndone\tO\n.\tO\n\nThere\tO\nare\tO\nseveral\tO\nprograms\tB-aspectTerm\nfor\tO\nschool\tB-aspectTerm\nor\tI-aspectTerm\noffice\tI-aspectTerm\nuse\tI-aspectTerm\n(\tO\nPages\tB-aspectTerm\n,\tO\nNumbers\tB-aspectTerm\n,\tO\nKeynote\tB-aspectTerm\n,\tO\netc\tO\n.\tO\n)\tO\n,\tO\nmusic\tB-aspectTerm\n(\tO\nGarageband\tB-aspectTerm\n)\tO\n,\tO\nphoto\tB-aspectTerm\nmanagement\tI-aspectTerm\n(\tO\nPhoto\tB-aspectTerm\nBooth\tI-aspectTerm\n,\tO\niPhoto\tB-aspectTerm\n)\tO\n,\tO\nvideo\tB-aspectTerm\n-\tI-aspectTerm\nediting\tI-aspectTerm\nor\tO\nmovie\tB-aspectTerm\n-\tI-aspectTerm\nmaking\tI-aspectTerm\n(\tO\niMovie\tB-aspectTerm\n)\tO\n,\tO\netc\tO\n.\tO\n\nThis\tO\nis\tO\nmy\tO\n3rd\tO\nApple\tO\nLaptop\tO\nand\tO\nfirst\tO\nMacBook\tO\nPro\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nthis\tO\nlaptop\tO\nfor\tO\na\tO\nfew\tO\nmonths\tO\nnow\tO\nand\tO\ni\tO\nwould\tO\nsay\tO\ni\tO\nm\tO\npretty\tO\nsatisfied\tO\n.\tO\n\nThe\tO\nlove\tO\npart\tO\nof\tO\nmy\tO\nrelationship\tO\nwith\tO\nthis\tO\nlaptop\tO\ndoes\tO\nn't\tO\ntake\tO\nvery\tO\nlong\tO\n.\tO\n\nNot\tO\nenough\tO\ntime\tO\nfor\tO\nme\tO\nto\tO\ngive\tO\nit\tO\n5\tO\nstars\tO\n!\tO\n\nThe\tO\nscreen\tB-aspectTerm\nshows\tO\ngreat\tO\ncolors\tB-aspectTerm\n.\tO\n\nReason\tO\nwhy\tO\n?\tO\nIt\tO\n's\tO\nbecause\tO\nwhen\tO\nyou\tO\nbuy\tO\nit\tO\n,\tO\nyou\tO\nknow\tO\nfirst\tO\nthing\tO\nthat\tO\nyou\tO\nwill\tO\nnot\tO\nlose\tO\nany\tO\nvalue\tB-aspectTerm\nfor\tO\nthat\tO\nlaptop\tO\n,\tO\nthe\tO\nprice\tB-aspectTerm\nwill\tO\nstay\tO\nthe\tO\nsame\tO\nfor\tO\nthe\tO\nnext\tO\nyear\tO\n,\tO\nand\tO\neven\tO\nif\tO\nApple\tO\ndoes\tO\ndecides\tO\nto\tO\nchange\tO\nmode\tO\n,\tO\nyour\tO\nlaptop\tO\nvalue\tB-aspectTerm\nwill\tO\nonly\tO\ndrop\tO\n10\tO\n-\tO\n20\tO\n%\tO\n,\tO\nunlike\tO\nPC\tO\nlaptops\tO\nwhich\tO\ndrop\tO\nmore\tO\nthan\tO\n80\tO\n%\tO\n.\tO\n\nThat\tO\n's\tO\na\tO\nhuge\tO\ndifference\tO\n.\tO\n\nDells\tO\nare\tO\nok\tO\n,\tO\nHPs\tO\nare\tO\nn't\tO\nthat\tO\ngood\tO\n,\tO\nbut\tO\nMacs\tO\nor\tO\nFantastic\tO\n.\tO\n\nSo\tO\n,\tO\nbuyers\tO\nbeware\tO\n!\tO\n\nI\tO\nam\tO\ntotally\tO\nsatisfied\tO\nwith\tO\nmy\tO\nlittle\tO\ntoshie\tO\n!\tO\n\nI\tO\nhave\tO\nno\tO\nidea\tO\nhow\tO\nto\tO\nburn\tB-aspectTerm\ncd\tI-aspectTerm\n's\tI-aspectTerm\nor\tO\nto\tO\nuse\tO\nthe\tO\nweb\tB-aspectTerm\ncam\tI-aspectTerm\n,\tO\njust\tO\nfor\tO\nstarters\tO\n.\tO\n\nAgain\tO\n,\tO\nI\tO\nsent\tO\nit\tO\noff\tO\nto\tO\nAcer\tO\n,\tO\nby\tO\nthis\tO\ntime\tO\nthey\tO\nwere\tO\npaying\tO\nfor\tO\nme\tO\nto\tO\nsend\tO\nit\tO\nto\tO\nthem\tO\nand\tO\neverything\tO\n,\tO\nbut\tO\nit\tO\nwas\tO\nstill\tO\ninconvienent\tO\nbecause\tO\nof\tO\nmy\tO\nclasses\tO\nand\tO\nmy\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\n.\tO\n\nDEFINITELY\tO\nrecommended\tO\n!\tO\n!\tO\n!\tO\n\nIt\tO\nis\tO\nextremely\tO\nuser\tO\nfriendly\tO\nand\tO\nintuitive\tO\n.\tO\n\nLet\tO\nme\tO\nstart\tO\nwith\tO\nthe\tO\ngood\tO\n:\tO\nSo\tO\nawesome\tO\n.\tO\n\nI\tO\nhad\tO\nfinally\tO\nreached\tO\nmy\tO\nlimit\tO\nand\tO\nbroke\tO\ndown\tO\n.\tO\n\nThe\tO\n17\tB-aspectTerm\ninch\tI-aspectTerm\nscreen\tI-aspectTerm\nis\tO\nvery\tO\nlarge\tO\n,\tO\nbut\tO\nthe\tO\ncomputer\tO\nis\tO\nvery\tO\nlight\tO\n.\tO\n\nMy\tO\nopinion\tO\nof\tO\nSony\tO\nhas\tO\nbeen\tO\ndropping\tO\nas\tO\nfast\tO\nas\tO\nthe\tO\nstock\tO\nmarket\tO\n,\tO\ngiven\tO\ntheir\tO\nhorrible\tO\nsupport\tO\n,\tB-aspectTerm\nbut\tO\nthis\tO\nmachine\tO\njust\tO\ncaused\tO\nanother\tO\nplunge\tO\n.\tO\n\nDo\tO\nI\tO\nlike\tO\nthe\tO\ncomputer\tO\n?\tO\nWell\tO\n,\tO\nother\tO\nthan\tO\nnot\tO\ngetting\tO\nviruses\tO\n,\tO\nI\tO\nguess\tO\nit\tO\nis\tO\nOK\tO\n.\tO\n\nFor\tO\nthe\tO\nBluetooth\tB-aspectTerm\nto\tO\nwork\tO\nproperly\tO\n,\tO\nyou\tO\nmust\tO\ninstall\tO\nthe\tO\nLaunch\tB-aspectTerm\nManager\tI-aspectTerm\non\tO\nthe\tO\nDrivers\tB-aspectTerm\n/\tI-aspectTerm\nApplications\tI-aspectTerm\nDVD\tI-aspectTerm\n,\tO\nor\tO\nit\tO\nwill\tO\nnot\tO\nshow\tO\nafter\tO\nthe\tO\nreload\tO\n.\tO\n\nI\tO\nwaited\tO\nand\tO\nwaited\tO\nand\tO\nno\tO\nlaptop\tO\n.\tO\n\nEverything\tO\nis\tO\nfalling\tO\napart\tO\ninternally\tO\nand\tO\nexternally\tO\n.\tO\n\nI\tO\nalso\tO\nliked\tO\nthe\tO\nglass\tB-aspectTerm\nscreen\tI-aspectTerm\n.\tO\n\nThe\tO\nswitchable\tB-aspectTerm\ngraphic\tI-aspectTerm\ncard\tI-aspectTerm\nis\tO\npretty\tO\nsweet\tO\nwhen\tO\nyou\tO\nwant\tO\ngaming\tB-aspectTerm\non\tO\nthe\tO\nlaptop\tO\n.\tO\n\nIt\tO\nsuper\tO\nshiny\tO\n,\tO\nso\tO\nyou\tO\ncan\tO\nsee\tO\nthe\tO\nfingerprints\tO\neasily\tO\n.\tO\n\nIt\tO\n's\tO\nnot\tO\na\tO\nwear\tO\n-\tO\nand\tO\n-\tO\ntear\tO\nissue\tO\n,\tO\nnot\tO\ndue\tO\nto\tO\nuser\tO\ncarelessness\tO\nand\tO\nmost\tO\nimportantly\tO\n,\tO\nthey\tO\nCAN'T\tO\nguarantee\tO\nthe\tO\nproblem\tO\nwill\tO\nbe\tO\nsolved\tO\nif\tO\nit\tO\nis\tO\nsent\tO\nfor\tO\nservice\tB-aspectTerm\nand\tO\nI\tO\nhave\tO\nto\tO\naccept\tO\nthe\tO\noutcome\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nhas\tO\nnot\tO\ndecreased\tO\nsince\tO\nI\tO\nbought\tO\nit\tO\n,\tO\nso\tO\ni\tO\n'm\tO\nthrilled\tO\nwith\tO\nthat\tO\n.\tO\n\nIts\tO\na\tO\ndog\tO\nplain\tO\nand\tO\nsimple\tO\n.\tO\n\nWhen\tO\nI\tO\ncalled\tO\nToshiba\tO\n,\tO\nthey\tO\nwould\tO\nnot\tO\ndo\tO\nanything\tO\nand\tO\neven\tO\ntried\tO\nto\tO\ncharge\tO\nme\tO\n$\tO\n35\tO\nfor\tO\nthe\tO\nphone\tO\ncall\tO\n,\tO\neven\tO\nthough\tO\nthey\tO\ndid\tO\nn't\tO\noffer\tO\nany\tO\ntechnical\tB-aspectTerm\nsupport\tI-aspectTerm\n.\tO\n\nMy\tO\nHP\tO\nis\tO\nvery\tO\nheavy\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nnotebook\tO\nand\tO\nonly\tO\nhad\tO\nit\tO\nfor\tO\n3\tO\nmonths\tO\nIf\tO\nit\tO\nis\tO\noverload\tO\nwith\tO\nupdates\tO\nthe\tO\nBOOT\tB-aspectTerm\nMGR\tI-aspectTerm\n.\tO\n\nOh\tO\nand\tO\nif\tO\nthat\tO\ns\tO\nnot\tO\nbad\tO\nenough\tO\nit\tO\ndoes\tO\nn't\tO\ncome\tO\nwith\tO\na\tO\nrecovery\tB-aspectTerm\ncd\tI-aspectTerm\nso\tO\nyou\tO\ncan\tO\nmake\tO\none\tO\nif\tO\nyou\tO\nknow\tO\nhow\tO\nto\tO\nor\tO\nbuy\tO\none\tO\nif\tO\nyou\tO\nbuy\tO\nit\tO\nthe\tO\ncost\tO\nis\tO\n$\tO\n25\tO\nfor\tO\ntwo\tO\ncds\tO\n.\tO\n\nThe\tO\nprice\tB-aspectTerm\nand\tO\nfeatures\tB-aspectTerm\nmore\tO\nthan\tO\nmet\tO\nmy\tO\nneeds\tO\n.\tO\n\nThey\tO\nrefuse\tO\n.\tO\n\nbig\tO\nmistake\tO\n!\tO\n\nBest\tO\nBuy\tO\nwas\tO\ngreat\tO\nas\tO\nalways\tO\nand\tO\naccepted\tO\nthe\tO\nreturn\tO\nand\tO\ngave\tO\nme\tO\nanother\tO\nmodel\tO\n1764\tO\n.\tO\n\nand\tO\ndell\tO\nand\tO\nbest\tO\nbuy\tO\nboth\tO\nrefused\tO\nto\tO\ntake\tO\nit\tO\nback\tO\nafter\tO\ni\tO\nonly\tO\nhad\tO\nit\tO\nfor\tO\n1\tO\nhour\tO\n....\tO\n\nMy\tO\nfriends\tO\nor\tO\nchildren\tO\nuse\tO\nthat\tO\nwhen\tO\nthey\tO\nneed\tO\nto\tO\nborrow\tO\nthe\tO\nNet\tO\n=)\tO\nWhen\tO\nI\tO\nout\tO\ngrow\tO\nthis\tO\nMeaning\tO\nwhen\tO\nits\tO\nold\tO\nand\tO\nmy\tO\noldest\tO\nchild\tO\nis\tO\nready\tO\nfor\tO\none\tO\nshe\tO\nwill\tO\nget\tO\nthis\tO\none\tO\nANd\tO\nI\tO\nwill\tO\nbe\tO\nbuying\tO\nonly\tO\nTOSHIBA\tO\n!\tO\n\nFirst\tO\nof\tO\nall\tO\n,\tO\nI\tO\n've\tO\nbeen\tO\nDell\tO\nfan\tO\nfor\tO\nmore\tO\nthan\tO\nfifteen\tO\nyears\tO\n.\tO\n\nGREAT\tO\nINVESTMENT\tO\n!\tO\n\nI\tO\nam\tO\njust\tO\namazed\tO\n.\tO\n\nI\tO\nburned\tO\nmy\tO\nleg\tO\n,\tO\nafter\tO\nlifting\tO\nit\tO\nfrom\tO\nmy\tO\ndesk\tO\n,\tO\nand\tO\nfor\tO\nless\tO\nthan\tO\n5\tO\nsecond\tO\nputting\tO\nit\tO\non\tO\nmy\tO\nlap\tO\nto\tO\nclean\tO\nmy\tO\ncoffee\tO\ntable\tO\n,\tO\nso\tO\nI\tO\ncan\tO\nplace\tO\nit\tO\nthere\tO\n.\tO\n\nI\tO\nthought\tO\nall\tO\nmy\tO\nproblems\tO\nwould\tO\nfinally\tO\nbe\tO\nsolved\tO\nbeing\tO\nthat\tO\nmy\tO\nold\tO\ncomputer\tO\nwould\tO\nn't\tO\ngo\tO\nonto\tO\nour\tO\nwireless\tO\nnetwork\tO\nand\tO\nI\tO\nwould\tO\nn't\tO\nhave\tO\nthe\tO\nsame\tO\nproblems\tO\nbecause\tO\nit\tO\nwas\tO\nupdated\tO\n.\tO\n\nSkype\tB-aspectTerm\nis\tO\njust\tO\nso\tO\ndang\tO\ncool\tO\nwith\tO\nthis\tO\nmachine\tO\ntoo\tO\n.\tO\n\nI\tO\nwould\tO\nbuy\tO\nthis\tO\nlap\tO\ntop\tO\nover\tO\nand\tO\nover\tO\nagain\tO\n!\tO\n\nthe\tO\nmouse\tB-aspectTerm\nbuttons\tI-aspectTerm\nare\tO\nhard\tO\nto\tO\npush\tO\n.\tO\n\nI\tO\ncan\tO\nactually\tO\nget\tO\nwork\tO\ndone\tO\nwith\tO\nthis\tO\nMAC\tO\n,\tO\nand\tO\nnot\tO\nfight\tO\nwith\tO\nit\tO\nlike\tO\nmy\tO\ntired\tO\nold\tO\nPC\tO\nlaptop\tO\n.\tO\n\nAlso\tO\n,\tO\nHDD\tB-aspectTerm\nsecures\tO\ninside\tO\nusing\tO\nrails\tB-aspectTerm\n,\tO\nand\tO\nthere\tO\nis\tO\nonly\tO\none\tO\nset\tO\non\tO\nthe\tO\nmain\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nIf\tO\nyou\tO\n're\tO\nnot\tO\nwanting\tO\nto\tO\nbe\tO\nmobile\tO\n,\tO\nthis\tO\nis\tO\na\tO\ngood\tO\nlaptop\tO\nto\tO\nsit\tO\non\tO\na\tO\ndesk\tO\n.\tO\n\nI\tO\nalso\tO\ntravel\tO\nwith\tO\nit\tO\nand\tO\nit\tO\nnever\tO\ngives\tO\nme\tO\nany\tO\nproblems\tO\n.\tO\n\nJust\tO\ndo\tO\nn't\tO\nwaste\tO\nyour\tO\ntime\tO\nand\tO\nmoney\tO\non\tO\nthis\tO\n.\tO\n\nAll\tO\nI\tO\nwill\tO\nsay\tO\nnow\tO\nis\tO\nthat\tO\nit\tO\nwas\tO\nover\tO\ntwo\tO\ngrand\tO\nless\tO\nexpensive\tO\nand\tO\nso\tO\nmuch\tO\nbetter\tO\nquality\tB-aspectTerm\nthan\tO\nmy\tO\nhunk\tO\nof\tO\ncrap\tO\nVaio\tO\n.\tO\n\n(\tO\nBeware\tO\n,\tO\ntheir\tO\nstaff\tB-aspectTerm\ncould\tO\nsend\tO\nyou\tO\nback\tO\nmaking\tO\nyou\tO\nfeel\tO\nthat\tO\nonly\tO\nthey\tO\nknow\tO\nwhat\tO\na\tO\ncomputer\tO\nis\tO\n.\tO\n\nAnd\tO\nI\tO\n'm\tO\nstill\tO\npaying\tO\nthe\tO\nbloody\tO\nfinancing\tO\n,\tO\nfor\tO\na\tO\nproduct\tO\nwhich\tO\ndid\tO\nn't\tO\nlast\tO\nme\tO\nat\tO\nleast\tO\nthree\tO\nyears\tO\n!\tO\n\nGames\tB-aspectTerm\nbeing\tO\nthe\tO\nmain\tO\nissue\tO\n.\tO\n\nNo\tO\nproblems\tO\n,\tO\nno\tO\nlock\tO\nups\tO\n,\tO\nno\tO\ndisappointments\tO\n.\tO\n\nWhile\tO\nthe\tO\ncomputer\tO\nseems\tO\nto\tO\nbe\tO\nset\tO\nup\tO\nin\tO\na\tO\ncommon\tO\nsense\tO\nway\tO\nrather\tO\nthan\tO\nin\tO\ngeek\tO\n-\tO\nspeak\tO\n,\tO\nthere\tO\nare\tO\ncertain\tO\nquirks\tO\nthat\tO\ncan\tO\ndrive\tO\nyou\tO\ncrazy\tO\ntrying\tO\nto\tO\ndeal\tO\nwith\tO\nthe\tO\nPC\tO\nworld\tO\n.\tO\n\nI\tO\nam\tO\ndefinitely\tO\nsold\tO\n,\tO\nand\tO\nnot\tO\ngoing\tO\nback\tO\nto\tO\nPCs\tO\nfor\tO\nhome\tO\nuse\tO\n!\tO\n\nI\tO\nhave\tO\na\tO\nlapdesk\tO\nwhich\tO\nI\tO\ncan\tO\nuse\tO\n,\tO\nbut\tO\nI\tO\ncan\tO\nstill\tO\nfeel\tO\nthe\tO\nheat\tO\nthrough\tO\nthe\tO\nfoam\tO\nand\tO\nplastic\tO\n.\tO\n\nand\tO\nits\tO\nreally\tO\ncheap\tO\nand\tO\nyou\tO\nwo\tO\nnt\tO\nregret\tO\nbuying\tO\nit\tO\n.\tO\n\nIt\tO\nwas\tO\nover\tO\nrated\tO\n!\tO\n\nI\tO\ndo\tO\nnt\tO\nunderstand\tO\nhow\tO\nanyone\tO\ncan\tO\nthink\tO\nthis\tO\nis\tO\na\tO\ngreat\tO\nproduct\tO\nworth\tO\npurchasing\tO\n.\tO\n\nMy\tO\nsister\tO\nhas\tO\nthe\tO\nsame\tO\nMac\tO\nas\tO\nme\tO\nand\tO\nshe\tO\nis\tO\nin\tO\na\tO\nband\tO\nand\tO\nuses\tO\nGarageBand\tB-aspectTerm\nto\tO\nrecord\tO\nand\tO\nedit\tO\n.\tO\n\nI\tO\nwas\tO\nn't\tO\nreally\tO\nsure\tO\nI\tO\nwanted\tO\nto\tO\nspend\tO\nthat\tO\nkind\tO\nof\tO\nmoney\tO\n!\tO\n\nOther\tO\nThoughts\tO\n:\tO\nDo\tO\nnot\tO\npurchase\tO\nthis\tO\nproduct\tO\n.\tO\n\nThey\tO\nsay\tO\nthat\tO\nthis\tO\nwill\tO\ninvalidate\tO\nthe\tO\nwarranty\tB-aspectTerm\non\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n(\tO\nI\tO\ndo\tO\nn't\tO\nreally\tO\nunderstand\tO\nwhy\tO\nbut\tO\nanyway\tO\n)\tO\n.\tO\n\nand\tO\nlooks\tO\nvery\tO\nsexyy\tO\n:\tO\nD\tO\nreally\tO\nthe\tO\nmac\tO\nbook\tO\npro\tO\nis\tO\nthe\tO\nbest\tO\nlaptop\tO\nspecially\tO\nfor\tO\nstudents\tO\nin\tO\ncollege\tO\nif\tO\nyou\tO\nare\tO\nnot\tO\ncaring\tO\nabout\tO\nprice\tO\n.\tB-aspectTerm\n\nI\tO\ntook\tO\nthe\tO\ncomputer\tO\nback\tO\nin\tO\nyet\tO\nagain\tO\nexcept\tO\nthis\tO\ntime\tO\nthey\tO\nkept\tO\nit\tO\nto\tO\nsend\tO\ninto\tO\ntheir\tO\nGeek\tO\nSquad\tO\nheadquarters\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\ngreat\tO\nlaptop\tO\nand\tO\nI\tO\nwould\tO\nrecommend\tO\nit\tO\nto\tO\nanyone\tO\n.\tO\n\nThank\tO\nGod\tO\nfor\tO\n\"\tO\nctrl\tO\nZ\"Bottom\tO\nline\tO\n,\tO\nI\tO\n've\tO\nbeen\tO\nusing\tO\nlaptops\tO\nsince\tO\nthe\tO\nmid\tO\n90s\tO\nand\tO\nprobably\tO\nthe\tO\nmajority\tO\nof\tO\nbrands\tO\nout\tO\nthere\tO\n.\tO\n\nThey\tO\ndefinitely\tO\nhave\tO\na\tO\nsuperior\tO\nproduct\tO\n!\tO\n\nA\tO\ngreat\tO\ncomputer\tO\nfor\tO\nlight\tO\nhome\tB-aspectTerm\nuse\tI-aspectTerm\nand\tO\nbusiness\tB-aspectTerm\nuse\tI-aspectTerm\n.\tO\n\nBought\tO\nit\tO\nto\tO\nuse\tO\nmostly\tO\nfor\tO\noline\tO\nclasses\tO\n.\tO\n\nEven\tO\nwith\tO\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\n,\tO\nit\tO\nalways\tO\nturned\tO\noff\tO\nwhen\tO\nupdates\tB-aspectTerm\nwere\tO\nneeded\tO\nand\tO\ninstalled\tO\n.\tO\n\nAlso\tO\nconsider\tO\nthe\tO\nMS\tB-aspectTerm\nOffice\tI-aspectTerm\napps\tI-aspectTerm\nare\tO\nall\tO\ntrial\tO\nversions\tO\n,\tO\nhope\tO\nyou\tO\nhave\tO\nyour\tO\nown\tO\ncopies\tO\n.\tO\n\nThey\tO\nare\tO\nwonderful\tO\n,\tO\nbut\tO\nvery\tO\ndangerous\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\nemitting\tO\nheat\tO\n.\tO\n\nThis\tO\ncomputer\tO\nwas\tO\nawful\tO\n!\tO\n\nHeck\tO\n,\tO\nif\tO\nI\tO\nhad\tO\nenough\tO\n'\tO\nmoney\tO\n,\tO\nI\tO\nwould\tO\nbut\tO\nit\tO\nas\tO\na\tO\ngift\tO\nfor\tO\nsomeone\tO\n.\tO\n\nEven\tO\nso\tO\n,\tO\nI\tO\nlike\tO\nplaying\tO\nonline\tO\ngames\tB-aspectTerm\n,\tO\nso\tO\nit\tO\nwas\tO\nwonderful\tO\nthat\tO\nthere\tO\nis\tO\na\tO\nfeature\tB-aspectTerm\nwhere\tO\nI\tO\ncan\tO\ndualboot\tO\nWindows\tB-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\namazingly\tO\nlong\tO\nat\tO\n7hrs\tO\nand\tO\n5hrs\tO\nif\tO\nyou\tO\nuse\tO\nit\tO\n.\tO\n\nMy\tO\nprevious\tO\npurchases\tO\nwere\tO\nwith\tO\nDell\tO\nand\tO\nHP\tO\n.\tO\n\nI\tO\nhave\tO\nnot\tO\nhave\tO\nany\tO\nproblems\tO\n.\tO\n\nI\tO\npurchased\tO\nan\tO\nHP\tO\nright\tO\nafter\tO\nmy\tO\nhigh\tO\nschool\tO\ngraduation\tO\n.\tO\n\nMe\tO\nand\tO\nmy\tO\nboyfriend\tO\nbought\tO\nthe\tO\nGateway\tO\nNV78\tO\nin\tO\nnov\tO\nof\tO\n09\tO\n.\tO\n\nIt\tO\nis\tO\nvery\tO\nuser\tO\nfriendly\tO\nand\tO\nnot\tO\nhard\tO\nto\tO\nfigure\tO\nout\tO\nat\tO\nall\tO\n.\tO\n\nlightweight\tO\n,\tO\nlong\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n,\tO\nexcellent\tO\ntransition\tO\nfrom\tO\nPC\tO\n;\tO\n\nThe\tO\nprice\tB-aspectTerm\nis\tO\nanother\tO\ndriving\tO\ninfluence\tO\nthat\tO\nmade\tO\nme\tO\npurchase\tO\nthis\tO\nlaptop\tO\n.\tO\n\nThe\tO\nNortons\tB-aspectTerm\nvirus\tI-aspectTerm\nscan\tI-aspectTerm\nis\tO\nonly\tO\nfor\tO\na\tO\nvery\tO\nshort\tO\ntime\tO\nunlike\tO\nothers\tO\nthat\tO\nusually\tO\nare\tO\ngood\tO\nfor\tO\na\tO\nyear\tO\n.\tO\n\nIt\tO\nis\tO\nstamped\tO\nand\tO\nnot\tO\nin\tO\npieces\tO\ntherefore\tO\nit\tO\nis\tO\na\tO\nstronger\tO\nmore\tO\nresilient\tO\nframe\tB-aspectTerm\n.\tO\n\nI\tO\nam\tO\nfirst\tO\ntime\tO\nMac\tO\nBuyer\tO\nand\tO\nam\tO\namazed\tO\nat\tO\nfeatures\tB-aspectTerm\nand\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\nthe\tO\nMac\tO\noffers\tO\n.\tO\n\nTwo\tO\n,\tO\nowning\tO\na\tO\n17\tO\nin.mac\tO\nbook\tO\ngives\tO\nthe\tO\nflexibility\tO\nto\tO\nsit\tO\nanywhere\tO\nyou\tO\nwant\tO\nwithout\tO\nworry\tO\nabout\tO\nbother\tO\nanyone\tO\n.\tO\n\nSent\tO\nunit\tO\nback\tO\nand\tO\nit\tO\n's\tO\nbeen\tO\ntwo\tO\nmonths\tO\n.\tO\n\nCame\tO\nfully\tO\nloaded\tB-aspectTerm\n-\tO\ngood\tO\n.\tO\n\nI\tO\nnoticed\tO\nwindows\tB-aspectTerm\nhas\tO\na\tO\nnew\tO\nsystem\tO\ncalled\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\n,\tO\nwhat\tO\nabout\tO\nus\tO\nVista\tB-aspectTerm\nusers\tO\n?\tO\nThey\tO\nshould\tO\nget\tO\nall\tO\nthe\tO\nbugs\tO\nout\tO\nof\tO\nVista\tO\nbefore\tO\ninvesting\tO\nin\tO\na\tO\nnew\tO\nsystem\tO\n.\tO\n\nWhen\tO\nwe\tO\nbought\tO\nour\tO\nnew\tO\nHP\tO\ncomouter\tO\nin\tO\nDec.\tO\nof\tO\n2008\tO\n,\tO\nwe\tO\nwanted\tO\nWindows\tB-aspectTerm\nXP\tI-aspectTerm\n,\tO\nbut\tO\nwere\tO\ntold\tO\nit\tO\nwould\tO\ncost\tO\nan\tO\nextra\tO\n$\tO\n159\tO\n,\tO\nso\tO\nwe\tO\nwent\tO\nwith\tO\nVista\tB-aspectTerm\n.\tO\n\n(\tO\nI\tO\ndefinatly\tO\nca\tO\nn't\tO\n)\tO\n.\tO\n\nFiles\tO\nas\tO\nwell\tO\nwould\tO\nbecome\tO\nlost\tO\n,\tO\ndeleted\tO\nor\tO\ncorrupted\tO\n.\tO\n\nIt\tO\nis\tO\nmeant\tO\nto\tO\nbe\tO\nPORTABLE\tO\n.\tO\n\nMy\tO\nlaptop\tO\nworked\tO\nagain\tO\nfor\tO\njust\tO\na\tO\nwhile\tO\nbefore\tO\nI\tO\nstarted\tO\nhaving\tO\nissues\tO\nAGAIN\tO\n.\tO\n\nThis\tO\nis\tO\nperfect\tO\nfor\tO\nher\tO\nfield\tO\n.\tO\n\ntaking\tO\nit\tO\nback\tO\nless\tO\nthan\tO\n24\tO\nhours\tO\nof\tO\npurchase\tO\n\nThat\tO\n's\tO\nthe\tO\ndownside\tO\nfor\tO\nme\tO\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nthat\tO\nI\tO\nhave\tO\n,\tO\nis\tO\nthe\tO\nkey\tB-aspectTerm\nbroad\tI-aspectTerm\nis\tO\na\tO\nlittle\tO\ndark\tO\nto\tO\nsee\tO\nthe\tO\nletters\tO\n,\tO\nwould\tO\nhelp\tO\nif\tO\nit\tO\nwas\tO\na\tO\nlittle\tO\nlighter\tO\nthen\tO\nit\tO\nis\tO\n.\tO\n\nHopefully\tO\nAmazon\tO\nwill\tO\ntake\tO\nthis\tO\nback\tO\n.\tO\n\nThey\tO\nended\tO\nup\tO\nkeeping\tO\nmy\tO\ncomputer\tO\nfor\tO\nalmost\tO\n3\tO\nmonths\tO\n!\tO\n\nI\tO\n'm\tO\nstill\tO\nwithin\tO\nthe\tO\none\tO\nyear\tO\nwarranty\tB-aspectTerm\nbut\tO\nthe\tO\nrepair\tB-aspectTerm\n\"\tI-aspectTerm\ndepot\tI-aspectTerm\n\"\tI-aspectTerm\nhas\tO\ndeemed\tO\nthat\tO\nthis\tO\ntime\tO\nit\tO\nwas\tO\ncaused\tO\nby\tO\nphysical\tO\nabuse\tO\nand\tO\nis\tO\nnot\tO\ncovered\tO\n.\tO\n\nBut\tO\nI\tO\nneeded\tO\na\tO\nlaptop\tO\nfor\tO\nschool\tO\nuse\tB-aspectTerm\n.\tI-aspectTerm\n\nhe\tO\nca\tO\nn't\tO\nstand\tO\nit\tO\n.\tO\n\nThe\tO\ncomputer\tO\nwas\tO\ndelivered\tO\nas\tO\npromised\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\ncomplete\tO\nopposite\tO\nto\tO\nan\tO\nergonomic\tO\ndesign\tB-aspectTerm\n.\tO\n\nI\tO\nwould\tO\nlike\tO\nat\tO\nleast\tO\na\tO\n4\tO\nhr\tO\n.\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nthat\tO\nI\tO\ndo\tO\nn't\tO\nlike\tO\nabout\tO\nmy\tO\nmac\tO\nis\tO\nthat\tO\nsometimes\tO\nthere\tO\nare\tO\nprograms\tB-aspectTerm\nthat\tO\nI\tO\nwant\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nrun\tO\nand\tO\nI\tO\nam\tO\nnot\tO\nable\tO\nto\tO\n.\tO\n\nLooking\tO\nonline\tO\n,\tO\nmany\tO\npeople\tO\nare\tO\nhaving\tO\nthe\tO\nsame\tO\nproblem\tO\n.\tO\n\nWireless\tB-aspectTerm\nhas\tO\nnot\tO\nbeen\tO\na\tO\nissue\tO\nfor\tO\nme\tO\n,\tO\nlike\tO\nsome\tO\nothers\tO\nhave\tO\nmeantioned\tO\n.\tO\n\nTHIS\tO\nIS\tO\nMY\tO\nSECOND\tO\nMAC\tO\nBOOK\tO\nPRO\tO\n.\tO\n\nMacBook\tO\nNotebooks\tO\nquickly\tO\ndie\tO\nout\tO\nbecause\tO\nof\tO\ntheir\tO\nshort\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n,\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\nmany\tO\nbackground\tO\nprograms\tB-aspectTerm\nthat\tO\nrun\tO\nwithout\tO\nthe\tO\nuser\tO\n's\tO\nknowlede\tO\n.\tO\n\nAll\tO\nthe\tO\nthings\tO\nyou\tO\ncan\tO\ndo\tO\nwith\tO\nthe\tO\ntrackpad\tB-aspectTerm\nmake\tO\nnavigating\tB-aspectTerm\naround\tO\nthe\tO\ncomputer\tO\nand\tO\nits\tO\nprograms\tB-aspectTerm\nso\tO\nmuch\tO\nsimpler\tO\n,\tO\nquicker\tO\n,\tO\nand\tO\neasier\tO\n.\tO\n\nI\tO\nguess\tO\nthe\tO\nonly\tO\ngood\tO\nthing\tO\nthat\tO\ncame\tO\nout\tO\nof\tO\nthese\tO\nwere\tO\nthe\tO\nspeakers\tB-aspectTerm\nand\tO\nthe\tO\nsubwoofer\tB-aspectTerm\n.\tO\n\nThere\tO\ns\tO\na\tO\nbuilt\tB-aspectTerm\nin\tI-aspectTerm\ncamera\tI-aspectTerm\nwith\tO\nspecial\tO\neffects-\tO\nfor\tO\nvideo\tO\nand\tO\nphotography\tO\n.\tO\n\nAll\tO\nfor\tO\nsuch\tO\na\tO\ngreat\tO\nprice\tB-aspectTerm\n.\tO\n\nI\tO\nwent\tO\nright\tO\nout\tO\nand\tO\npurchased\tO\nanother\tO\nlaptop\tO\n.\tO\n\nLong\tO\nstory\tO\nshort\tO\n,\tO\nsince\tO\nI\tO\nexperience\tO\nso\tO\nmany\tO\nproblems\tO\nwith\tO\nmy\tO\nlaptop\tO\nevery\tO\nsince\tO\nI\tO\nbought\tO\nit\tO\nfrom\tO\nday\tO\none\tO\n,\tO\nI\tO\ndid\tO\nn't\tO\nask\tO\nfor\tO\na\tO\nnew\tO\nlaptop\tO\nor\tO\na\tO\nrefund\tO\nof\tO\nwhat\tO\nI\tO\npay\tO\nfor\tO\na\tO\ncrapy\tO\nlaptop\tO\n,\tO\nbut\tO\njust\tO\nan\tO\nextension\tO\nof\tO\nmy\tO\nlaptop\tO\nwarranty\tO\nfor\tB-aspectTerm\nanother\tO\nyear\tO\n,\tO\nthey\tO\nmade\tO\na\tO\nbig\tO\ndeal\tO\nof\tO\nout\tO\nthat\tO\nand\tO\nafter\tO\nso\tO\nmany\tO\ncalls\tO\nand\tO\ncomplaints\tO\nabout\tO\ntheir\tO\nproducts\tO\nand\tO\nservices\tO\n,\tO\nthey\tO\nfinally\tO\ngave\tO\nin\tO\n.\tO\n\nI\tO\nam\tO\nable\tO\nto\tO\nplay\tO\n720p\tO\nand\tO\n1080p\tO\nmedia\tO\nfiles\tO\njust\tO\nfine\tO\nwith\tO\nit\tO\n.\tO\n\nI\tO\nalready\tO\nown\tO\nan\tO\niPhone\tO\n,\tO\nand\tO\nso\tO\nthe\tO\nmove\tO\njust\tO\nmade\tO\nmore\tO\nsense\tO\n.\tO\n\nSo\tO\nthink\tO\nabout\tO\nfactoring\tO\nthose\tO\nthings\tO\nin\tO\nwhen\tO\nyou\tO\npurchase\tO\n.\tO\n\nTook\tO\nthe\tO\nnetbook\tO\non\tO\na\tO\nvacation\tO\ntrip\tO\nand\tO\nI\tO\nwas\tO\nable\tO\nto\tO\ndo\tO\nwhatever\tO\nI\tO\nwanted\tO\nto\tO\ndo\tO\nwithout\tO\nlugging\tO\na\tO\nmuch\tO\nheavier\tO\nlaptop\tO\n.\tO\n\nEverything\tO\nwas\tO\nup\tO\nand\tO\nrunning\tO\nwithin\tO\n15\tO\nminutes\tO\nof\tO\nunboxing\tO\n.\tO\n\nThis\tO\ncomputer\tO\ngets\tO\nvery\tO\nhot\tO\n,\tO\nbefore\tO\nshutting\tO\ndown\tO\n.\tO\n\nAnother\tO\nthing\tO\nis\tO\nthat\tO\nafter\tO\nonly\tO\na\tO\nmonth\tO\nthe\tO\nleft\tB-aspectTerm\nmouse\tI-aspectTerm\nkey\tI-aspectTerm\nbroke\tO\nand\tO\nit\tO\ncosted\tB-aspectTerm\n$\tO\n175\tO\nto\tO\nsend\tO\nit\tO\nin\tO\nto\tO\nfix\tO\nit\tO\n.\tO\n\nWent\tO\nsilently\tO\n.\tO\n\nSatisfy\tO\nwhat\tO\nI\tO\npaid\tO\nfor\tO\nit\tO\n.\tO\n\nIT\tO\nIS\tO\nTRASH\tO\n!\tO\n\nIt\tO\nhas\tO\ngood\tO\nspeed\tB-aspectTerm\nand\tO\nplenty\tO\nof\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nspace\tI-aspectTerm\n.\tO\n\nClear\tO\npicture\tB-aspectTerm\non\tO\nit\tO\nand\tO\neverything\tO\n.\tO\n\nOverall\tO\nthough\tO\n,\tO\nfor\tO\nthe\tO\nmoney\tO\nspent\tO\nit\tO\n's\tO\na\tO\ngreat\tO\ndeal\tO\n.\tO\n\nSo\tO\nyou\tO\ndo\tO\nn't\tO\nget\tO\nfrustrated\tO\nthe\tO\nfirst\tO\nfew\tO\nweeks\tO\n.\tO\n\nThey\tO\nsaid\tO\nthat\tO\nmy\tO\ncomputer\tO\nwas\tO\ncovered\tO\non\tO\nan\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\n,\tO\nand\tO\nthat\tO\nproducts\tO\nwith\tO\nextended\tO\nwarranties\tB-aspectTerm\nare\tO\ntaken\tO\ncare\tO\nof\tO\nthrough\tO\nthird\tO\nparties\tO\nand\tO\nnot\tO\nSony\tO\nitself\tO\nanymore\tO\n.\tO\n\nIt\tO\n's\tO\nso\tO\nuseable\tO\nand\tO\nresponsive\tO\n.\tO\n\nIt\tO\nis\tO\ntruly\tO\na\tO\nDesktop\tO\nReplacement\tO\n.\tO\n\nI\tO\nonly\tO\nused\tO\nit\tO\nto\tO\nbrowse\tO\nthe\tO\ninternet\tO\nand\tO\nand\tO\nI\tO\ndo\tO\nnt\tO\nknow\tO\nhow\tO\nmany\tO\ntimes\tO\nit\tO\nhas\tO\nspontaniously\tO\nshut\tO\ndown\tO\nand\tO\nit\tO\nis\tO\njust\tO\na\tO\nblank\tO\nscreen\tO\nnow\tO\n.\tO\n\nA\tO\nlittle\tO\npricey\tO\nbut\tO\nit\tO\nis\tO\nwell\tO\n,\tO\nwell\tO\nworth\tO\nit\tO\n.\tO\n\nVery\tO\nlong\tO\n-\tO\nlife\tO\nbattery\tB-aspectTerm\n(\tO\nup\tO\nto\tO\n10\tO\n-\tO\n11\tO\nhours\tO\ndepending\tO\non\tO\nhow\tO\nyou\tO\nconfigure\tO\npower\tO\nlevel\tO\nsettings\tO\n)\tO\n.\tO\n\nScreen\tB-aspectTerm\nis\tO\nawesome\tO\n,\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\ngood\tO\n.\tO\n\nThe\tO\nblack\tO\nmodel\tO\nalso\tO\nhas\tO\na\tO\nvery\tO\nnice\tO\nseamless\tO\nappearance\tB-aspectTerm\n-\tO\none\tO\nof\tO\nthe\tO\nbetter\tO\nlooking\tO\nnotebooks\tO\nI\tO\n've\tO\nseen\tO\n.\tO\n\nIn\tO\nmy\tO\nopinion\tO\nit\tO\nwas\tO\nnot\tO\nas\tO\nuser\tO\nfriendly\tO\nas\tO\nI\tO\nexpected\tO\neither\tO\n.\tO\n\nThe\tO\ntechnical\tB-aspectTerm\nservice\tI-aspectTerm\nfor\tI-aspectTerm\ndell\tI-aspectTerm\nis\tO\nso\tO\n3rd\tO\nworld\tO\nit\tO\nmight\tO\nas\tO\nwell\tO\nnot\tO\neven\tO\nbother\tO\n.\tO\n\nThe\tO\ngraphics\tB-aspectTerm\nwere\tO\nawful\tO\nand\tO\nthe\tO\nwarranty\tB-aspectTerm\nis\tO\nn't\tO\neven\tO\nworth\tO\nthe\tO\ncheap\tO\npayment\tO\non\tO\nthe\tO\ncomputer\tO\n.\tO\n\nand\tO\nif\tO\nu\tO\ndid\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nthe\tO\nMacBook\tO\nPro\tO\n15\tO\nfor\tO\nabout\tO\nthree\tO\nweeks\tO\n,\tO\nand\tO\nit\tO\nreally\tO\nis\tO\na\tO\ngreat\tO\ncomputer\tO\n.\tO\n\nThey\tO\ngave\tO\nme\tO\na\tO\nhard\tO\ntime\tO\nyet\tO\nagain\tO\n,\tO\nbut\tO\ntheir\tO\nwas\tO\na\tO\nmalfunction\tO\nin\tO\nthe\tO\nbattery\tB-aspectTerm\nitself\tO\n,\tO\nit\tO\ndid\tO\nn't\tO\ndie\tO\n.\tO\n\nIt\tO\nwas\tO\ndefinelty\tO\na\tO\nsmart\tO\nmove\tO\n.\tO\n\nI\tO\n'm\tO\nexcited\tO\nto\tO\nlearn\tO\nmore\tO\nabout\tO\nwhat\tO\nthis\tO\npowerful\tO\nmachine\tO\nhas\tO\nto\tO\noffer\tO\nand\tO\nencourage\tO\nothers\tO\nto\tO\ndo\tO\nthe\tO\nsame\tO\n.\tO\n\nApparently\tO\nthey\tO\nare\tO\ndefective\tO\nsince\tO\nthey\tO\nare\tO\nnot\tO\nsecurely\tO\nattached\tO\n.\tO\n\nbut\tO\nother\tO\nthen\tO\nthat\tO\nI\tO\nwould\tO\ngive\tO\nthis\tO\nproduct\tO\na\tO\n4\tO\nin\tO\nhafe\tO\nstars\tO\n.\tO\n\nSure\tO\nhope\tO\nBest\tO\nBuy\tO\nwill\tO\nreplace\tO\nit\tO\nasap\tO\n.\tO\n\nI\tO\nbabyed\tO\nthe\tO\nheck\tO\nout\tO\nof\tO\nit\tO\nand\tO\ni\tO\nstill\tO\ndo\tO\n.\tO\n\nHandles\tO\nall\tO\nmy\tO\nbasic\tO\nmedia\tO\nneeds\tO\neasily\tO\n.\tO\n\nJust\tO\nwhat\tO\nthe\tO\ndoctor\tO\nordered\tO\n.\tO\n\nIf\tO\nyou\tO\ndo\tO\nn't\tO\nfeel\tO\ncomfortable\tO\ndoing\tO\nit\tO\nyourself\tO\n,\tO\njust\tO\nbuy\tO\nthe\tO\ncase\tB-aspectTerm\nand\tO\nbe\tO\nhappy\tO\n,\tO\nplus\tO\nit\tO\nlooks\tO\nnice\tO\n,\tO\nI\tO\nbought\tO\nthe\tO\nwhite\tO\none\tO\nfrom\tO\nBest\tO\nBuy\tO\n.\tO\n\nThe\tO\nreaction\tO\nof\tO\nToshiba\tO\nis\tO\nthere\tO\nis\tO\nnothing\tO\nyou\tO\ncan\tO\ndo\tO\nabout\tO\nit\tO\nso\tO\njust\tO\nsit\tO\nback\tO\nand\tO\nexcept\tO\nthe\tO\nfact\tO\nthat\tO\nyou\tO\nare\tO\npowerless\tO\nand\tO\nit\tO\nis\tO\nmind\tO\nover\tO\nmatter\tO\n.\tO\n\nyou\tO\ncan\tO\nfind\tO\nmany\tO\nlaptops\tO\nwith\tO\nthe\tO\nsame\tO\nperformance\tB-aspectTerm\nand\tO\neven\tO\nbetter\tO\nwith\tO\nlower\tO\nprice\tB-aspectTerm\n,\tO\nbut\tO\nyou\tO\ncan\tO\nnot\tO\nfind\tO\nthe\tO\nlook\tB-aspectTerm\n,\tO\neasy\tO\n,\tO\napplications\tB-aspectTerm\n,\tO\nand\tO\nthe\tO\nexperience\tO\nin\tO\nmac\tO\n.\tO\n\nExcellent\tO\nspeed\tB-aspectTerm\nfor\tO\nprocessing\tO\ndata\tO\n.\tO\n\nAll\tO\nin\tO\nall\tO\n,\tO\nI\tO\n'm\tO\nincredibly\tO\ndissatisfied\tO\nwith\tO\nthis\tO\nlaptop\tO\n,\tO\nand\tO\nwith\tO\nHP\tO\nas\tO\na\tO\nwhole\tO\n.\tO\n\nI\tO\nam\tO\nnot\tO\nhappy\tO\nat\tO\nall\tO\nwith\tO\nthe\tO\nproduct\tO\nI\tO\npurchased\tO\n.\tO\n\nWhen\tO\nyou\tO\ncall\tO\ntech\tB-aspectTerm\nsupport\tI-aspectTerm\nyou\tO\nwere\tO\nrouted\tO\nto\tO\nsomeone\tO\nwho\tO\nwas\tO\nin\tO\nanother\tO\ncountry\tO\nand\tO\ndid\tO\nnot\tO\nknow\tO\nwhat\tO\nthey\tO\nwere\tO\ndoing\tO\n.\tO\n\nIt\tO\nhas\tO\ncome\tO\ninto\tO\ngood\tO\nuse\tB-aspectTerm\nfor\tO\nmy\tO\nfinances\tO\n,\tO\nscheduling\tO\n,\tO\nmy\tO\nparents\tO\nbusiness\tO\nexpenses\tO\n,\tO\nand\tO\nit\tO\nis\tO\ndefinitely\tO\namazing\tO\nfor\tO\ngaming\tB-aspectTerm\n.\tO\n\nI\tO\nwas\tO\ntaught\tO\nto\tO\nuse\tO\nPhotoshop\tB-aspectTerm\nand\tO\nwas\tO\namazed\tO\n.\tO\n\nIt\tO\n's\tO\nA\tO\nMAC\tO\n!\tO\n!\tO\n\nIt\tO\nwas\tO\nweird\tO\n.\tO\n\nI\tO\ncan\tO\nhardly\tO\nwait\tO\nto\tO\nsee\tO\nwhat\tO\ns\tO\naround\tO\nthe\tO\nnext\tO\ncorner\tO\n.\tO\n\nthe\tO\napple\tO\npro\tO\nnotebook\tO\nwill\tO\nnot\tO\nlet\tO\nyou\tO\ndown\tO\n.\tO\n\nI\tO\ndid\tO\na\tO\nreview\tO\non\tO\nit\tO\n,\tO\nits\tO\nawesome\tO\n.\tO\n\nBefore\tO\nwe\tO\ngot\tO\nthis\tO\nlaptop\tO\n,\tO\nhad\tO\na\tO\ncompaq\tO\npasaro\tO\nfor\tO\n5\tO\nyears\tO\nwith\tO\nno\tO\nproblems\tO\n.\tO\n\nI\tO\ntried\tO\nout\tO\nanother\tO\nMac\tO\nfor\tO\na\tO\nfew\tO\nmonths\tO\nbefore\tO\nbuying\tO\nthis\tO\none\tO\nand\tO\nit\tO\nis\tO\na\tO\ngreat\tO\nmachine\tO\n.\tO\n\nSomehow\tO\nthe\tO\nsystem\tB-aspectTerm\nclock\tI-aspectTerm\ngot\tO\nmessed\tO\nup\tO\nafter\tO\nreboot\tO\n.\tO\n\nthe\tO\nonly\tO\nproblem\tO\nis\tO\nthat\tO\ni\tO\nhad\tO\nto\tO\nadd\tO\n1\tO\ngb\tO\nRAM\tB-aspectTerm\n,\tO\nthe\tO\ncomputer\tO\nwas\tO\nkinda\tO\nslow\tO\n.\tO\n\nWith\tO\nthe\tO\nmacbook\tO\npro\tO\nit\tO\ncomes\tO\nwith\tO\nfreesecuritysoftware\tO\nto\tO\nprotect\tO\nit\tO\nfrom\tO\nviruses\tO\nand\tO\nother\tO\nintrusive\tO\nthings\tO\nfrom\tO\ndownloads\tO\nand\tO\ninternet\tO\nsurfing\tO\nor\tO\nemails\tO\n.\tO\n\nThe\tO\ncomputer\tO\ncould\tO\nhave\tO\nbeen\tO\nshipped\tO\nby\tO\nPriority\tO\nMail\tO\nthrough\tO\nthe\tO\nUSPS\tO\nfor\tO\nthe\tO\nsame\tO\ncost\tO\nand\tO\narrived\tO\nby\tO\nNoon\tO\non\tO\nTue\tO\n.\tO\n\nI\tO\nvisited\tO\nthe\tO\nApple\tO\nStore\tO\nand\tO\nwas\tO\nimpressed\tO\nwith\tO\nthe\tO\n17-inch\tO\nMacBook\tO\nPro\tO\n.\tO\n\nThe\tO\ndriver\tB-aspectTerm\nupdates\tI-aspectTerm\ndo\tO\nn't\tO\nfix\tO\nthe\tO\nissue\tO\n,\tO\nvery\tO\nfrustrating\tO\n.\tO\n\nI\tO\nwill\tO\nnever\tO\ngo\tO\nback\tO\nto\tO\nWindows\tB-aspectTerm\n!\tO\n\nDo\tO\nyour\tO\nresearch\tO\non\tO\nthis\tO\nissue\tO\n.\tO\n\nLooking\tO\nto\tO\ntake\tO\nmy\tO\nvideo\tO\nand\tO\nphoto\tO\nediting\tO\nto\tO\nthe\tO\nnext\tO\nlevel\tO\n,\tO\nI\tO\ndecided\tO\nto\tO\npurchase\tO\nthe\tO\nMBP\tO\n15\tO\nin\tO\nIntel\tO\nCore\tO\ni5\tO\nafter\tO\nreading\tO\nconsumer\tO\nreviews\tO\nas\tO\nwell\tO\nas\tO\nprofessional\tO\nreviews\tO\nof\tO\nthis\tO\nlaptop\tO\n.\tO\n\nIt\tO\ndoes\tO\nnt\tO\nwork\tB-aspectTerm\nworth\tO\na\tO\ndamn\tO\n.\tO\n\nHP\tO\nPavilion\tO\nDV9000\tO\nNotebook\tO\nPC\tO\nWhen\tO\nI\tO\nfirst\tO\ngot\tO\nthis\tO\ncomputer\tO\n,\tO\nit\tO\nreally\tO\nrocked\tO\n.\tO\n\nIt\tO\nworks\tB-aspectTerm\nreally\tO\nwell\tO\n.\tO\n\nIt\tO\nhas\tO\nhappened\tO\nagain\tO\nand\tO\nI\tO\n'm\tO\nbeing\tO\ntold\tO\nthat\tO\nit\tO\n's\tO\n$\tO\n175\tO\n.\tO\n\nBigger\tO\nHD\tB-aspectTerm\n,\tO\nbetter\tO\ngraphics\tB-aspectTerm\ncard\tI-aspectTerm\n,\tO\nand\tO\na\tO\nbid\tO\nHD\tB-aspectTerm\n.\tO\n\nLord\tO\nHAVE\tO\nMERCY\tO\n!\tO\n\nThe\tO\nbuilt\tB-aspectTerm\nin\tI-aspectTerm\ncamera\tI-aspectTerm\nis\tO\nvery\tO\nuseful\tO\nwhen\tO\nchatting\tO\nwith\tO\nother\tO\ntechs\tO\nin\tO\nremote\tO\nbuildings\tO\non\tO\nour\tO\ncampus\tO\n.\tO\n\nNo\tO\nbig\tO\ndeal\tO\n.\tO\n\nMine\tO\ncame\tO\nat\tO\n$\tO\n1,700\tO\nw/o\tO\na\tO\nDVD\tB-aspectTerm\nburner\tI-aspectTerm\n(\tO\n!\tO\n)\tO\n.\tO\n\nThe\tO\nDVD\tB-aspectTerm\nburner\tI-aspectTerm\nbroke\tO\nafter\tO\nburning\tO\n3\tO\nDVD'd\tO\nduring\tO\nthat\tO\ntime\tO\n!\tO\n\nIt\tO\nworks\tB-aspectTerm\nfine\tO\nwith\tO\nour\tO\nwireless\tO\nand\tO\nthey\tO\n've\tO\nhad\tO\nnot\tO\nproblems\tO\n.\tO\n\nBut\tO\nyou\tO\nmust\tO\nget\tO\nthe\tO\n15\tB-aspectTerm\ninch\tI-aspectTerm\n.\tO\n\ni\tO\nwill\tO\nbe\tO\nreturning\tO\nit\tO\nand\tO\nswitching\tO\nbrands\tO\nwhen\tO\ni\tO\nget\tO\nto\tO\nbest\tO\nbuy\tO\n.\tO\n\nProduct\tB-aspectTerm\nsupport\tI-aspectTerm\nvery\tO\npoor\tO\nas\tO\neach\tO\nphone\tO\ncall\tO\ncosts\tO\nme\tO\nlong\tO\ndistan\tO\n\nOverall\tO\nthe\tO\ncomputer\tO\nis\tO\nvery\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nthe\tO\nscreen\tB-aspectTerm\nis\tO\nperfect\tO\n,\tO\ngreat\tO\ncomputer\tO\n,\tO\nmy\tO\ndaughter\tO\nloves\tO\n.\tO\n\nThe\tO\ncasing\tO\nof\tB-aspectTerm\nthe\tI-aspectTerm\npower\tI-aspectTerm\ncord\tI-aspectTerm\nfried\tI-aspectTerm\nand\tO\nshocked\tO\nmy\tO\nhusband\tO\nwhen\tO\nhe\tO\npulled\tO\nit\tO\nout\tO\nof\tO\nthe\tO\nsocket\tO\n.\tO\n\nIt\tO\ndoes\tO\nnot\tO\nkeep\tO\ninternet\tB-aspectTerm\nsignals\tI-aspectTerm\nno\tO\nmatter\tO\nwhere\tO\nyou\tO\nbring\tO\nit\tO\n.\tO\n\napple\tO\nis\tO\none\tO\nof\tO\nthe\tO\nbest\tO\ncomputer\tO\ncompanies\tO\nin\tO\nthe\tO\ncountry\tO\n.\tO\n\nPLEASE\tO\nMAKE\tO\nTHESE\tO\n!\tO\n\nFrustrated\tO\nI\tO\nhung\tO\nup\tO\nand\tO\ntried\tO\nto\tO\ncall\tO\nback\tO\n3\tO\ndays\tO\nlater\tO\nto\tO\nbe\tO\ntold\tO\nthat\tO\nit\tO\ntakes\tO\n2\tO\n-\tO\n3\tO\ndays\tO\nfor\tO\nturnaround\tO\ntime\tO\n.\tO\n\nAfter\tO\nthe\tO\nfirst\tO\nfew\tO\nmonths\tO\n,\tO\nthe\tO\ncomputer\tO\nstarted\tO\ncrashing\tO\nabout\tO\nevery\tO\nweek\tO\n.\tO\n\nMy\tO\nson\tO\nand\tO\nhis\tO\nfamily\tO\nhave\tO\na\tO\nhard\tO\ntime\tO\nfinancially\tO\nbecause\tO\nhe\tO\nis\tO\nself\tO\n-\tO\nemployed\tO\nso\tO\nthe\tO\nfamily\tO\nhad\tO\nno\tO\ncomputer\tO\nof\tO\nany\tO\nkind\tO\n,\tO\nand\tO\nkyle\tO\nthe\tO\noldest\tO\nchild\tO\nis\tO\n12\tO\nand\tO\nreally\tO\nneed\tO\nsomething\tO\nto\tO\nhelp\tO\nhim\tO\nin\tO\nschool\tO\n.\tO\n\nIt\tO\n's\tO\na\tO\ngreat\tO\nproduct\tO\nfor\tO\na\tO\ngreat\tO\nprice\tB-aspectTerm\n!\tO\n\nAgain\tO\n,\tO\nthe\tO\nsame\tO\nproblem\tO\n,\tO\nthe\tO\nright\tB-aspectTerm\nspeaker\tI-aspectTerm\ndid\tO\nnot\tO\nwork\tO\n.\tO\n\nBut\tO\nsee\tO\nthe\tO\nmacbook\tO\npro\tO\nis\tO\ndifferent\tO\nbecause\tO\nit\tO\nmay\tO\nhave\tO\na\tO\nhuge\tO\nprice\tB-aspectTerm\ntag\tI-aspectTerm\nbut\tO\nit\tO\ncomes\tO\nwith\tO\nthe\tO\nfull\tO\nsoftware\tB-aspectTerm\nthat\tO\nyou\tO\nwould\tO\nactually\tO\nneed\tO\nand\tO\nmost\tO\nof\tO\nit\tO\nhas\tO\nfree\tO\nfuture\tO\nupdates\tB-aspectTerm\n.\tO\n\nBefore\tO\ni\tO\nbought\tO\nmy\tO\nnew\tO\ni5\tO\n,\tO\nI\tO\ndid\tO\nmy\tO\nresearch\tO\nfor\tO\nabout\tO\n2\tO\nweeks\tO\nand\tO\ndetermined\tO\nto\tO\nmove\tO\nfor\tO\nHP\tO\nto\tO\nApple\tO\nfor\tO\nreliability\tO\n,\tO\ndependable\tO\n,\tO\nand\tO\nlong\tO\nlasting\tO\noperations\tO\n.\tO\n\nDell\tO\nwanted\tO\nto\tO\ncharge\tO\nus\tO\nfor\tO\neverything\tO\neverytime\tO\nI\tO\ncalled\tO\nthem\tO\nwith\tO\na\tO\nproblem\tO\n.\tO\n\nTHIS\tO\nHAS\tO\nBEEN\tO\nNOTHING\tO\nBUT\tO\nA\tO\nHEADACHE\tO\nSINCE\tO\nWE\tO\nPURCHASED\tO\nIT\tO\n.\tO\n\ni\tO\nhave\tO\nhad\tO\nmy\tO\ndell\tO\nlatitude\tO\nfor\tO\nalmost\tO\nthree\tO\nyears\tO\n.\tO\n\nMay\tO\nbe\tO\nbetter\tO\nfor\tO\nthe\tO\noccasional\tO\nweb\tO\nsurfer\tO\n.\tO\n\nand\tO\nthe\tO\nmultiple\tB-aspectTerm\npage\tI-aspectTerm\nviewer\tI-aspectTerm\n(\tO\nallows\tO\nyou\tO\nto\tO\npress\tO\none\tO\nbutton\tO\nto\tO\nsee\tO\nevery\tO\nseparate\tO\npage\tO\ncurrently\tO\nopened\tO\nat\tO\nthe\tO\nsame\tO\ntime\tO\nin\tO\none\tO\nscreen\tO\n)\tO\nare\tO\ngreat\tO\nfor\tO\nthose\tO\nwho\tO\nare\tO\nworking\tO\nnon\tO\nstop\tO\nor\tO\njust\tO\nshopping\tO\nonline\tO\n.\tO\n\nThis\tO\nwas\tO\nthe\tO\n3rd\tO\nday\tO\nand\tO\npart\tO\nstill\tO\nhad\tO\nnot\tO\nbeen\tO\nshipped\tB-aspectTerm\n.\tO\n\nObviously\tO\nwe\tO\nboth\tO\ngot\tO\nnew\tO\nMacs\tO\n.\tO\n\nMy\tO\nIphone\tO\nsynced\tO\nright\tO\nup\tO\njust\tO\nlike\tO\na\tO\nperson\tO\nwould\tO\nexpect\tO\n,\tO\nunlike\tO\nthe\tO\nPCs\tO\nin\tO\nour\tO\nlives\tO\n.\tO\n\nThat\tO\nbeing\tO\nsaid\tO\nafter\tO\n2\tO\nweeks\tO\nof\tO\nowning\tO\nevery\tO\ntime\tO\nI\tO\nstart\tO\nit\tO\nup\tO\nnow\tO\nit\tO\ngives\tO\nme\tO\na\tO\nblack\tO\nscreen\tO\nfor\tO\n5\tO\n-\tO\n8\tO\nseconds\tO\nstating\tO\npxe\tO\n-\tO\ne61\tO\nmedia\tO\ntest\tO\nerror\tO\ncheck\tO\ncable\tO\n.\tO\n\nIt\tO\n's\tO\nfun\tO\nto\tO\ntake\tO\nto\tO\na\tO\nbookstore\tO\n,\tO\nsit\tO\nin\tO\nthe\tO\ncoffee\tO\nshop\tO\narea\tO\n,\tO\nsign\tO\nin\tO\nto\tO\nWiFi\tO\nand\tO\nlook\tO\nup\tO\nbook\tO\nreviews\tO\nof\tO\nbooks\tO\nI\tO\nmight\tO\nbuy\tO\n.\tO\n\nNot\tO\nsuper\tO\nfancy\tO\n,\tO\nbut\tO\nnot\tO\nsuper\tO\nexpensive\tO\neither\tO\n.\tO\n\nKeyboard\tB-aspectTerm\ngood\tO\nsized\tO\nand\tO\nwasy\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nHP\tO\nsaid\tO\nit\tO\nwas\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\n.\tO\n\n-Stay\tO\naway\tO\nfrom\tO\nApple\tO\n,\tO\nor\tO\nhope\tO\nyou\tO\nlaptop\tO\ndoes\tO\nnot\tO\nbreak\tO\ndown\tO\n.\tO\n\nIt\tO\n's\tO\na\tO\ngreat\tO\nprodcut\tO\nto\tO\nhandle\tO\nbasic\tO\ncomputing\tO\nneeds\tO\n.\tO\n\nI\tO\nnever\tO\nhad\tO\nthis\tO\nkind\tO\nof\tO\nquality\tB-aspectTerm\nissue\tO\nwith\tO\nDell\tO\n(\tO\nnot\tO\nto\tO\nsay\tO\nDell\tO\nis\tO\nthat\tO\ngreat\tO\n)\tO\n,\tO\nnot\tO\nwith\tO\na\tO\nbrand\tO\nnew\tO\nlaptop\tO\n.\tO\n\nwonderful\tO\nfeatures\tB-aspectTerm\n.\tO\n\nthe\tO\nlaptop\tO\nwas\tO\nreally\tO\ngood\tO\nand\tO\nit\tO\ngoes\tO\nreally\tO\nfast\tO\njust\tO\nthe\tO\nway\tO\ni\tO\nthought\tO\nit\tO\nwould\tO\nof\tO\nrun\tO\n.\tO\n\nI\tO\nhad\tO\nto\tO\ncall\tO\nHP\tO\nand\tO\nask\tO\nfor\tO\na\tO\nrecovery\tB-aspectTerm\ndisk\tI-aspectTerm\nbecause\tO\nthe\tO\ncomputer\tO\ndoes\tO\nnot\tO\ncome\tO\nwith\tO\none\tO\nand\tO\ncompletely\tO\nredo\tO\nit\tO\nall\tO\n.\tO\n\nI\tO\nm\tO\nglad\tO\nthat\tO\nit\tO\nhas\tO\nsuch\tO\ngreat\tO\nfeatures\tB-aspectTerm\nin\tO\nit\tO\n.\tO\n\nit\tO\n's\tO\njust\tO\na\tO\ngreat\tO\ntoy\tO\nto\tO\nhave\tO\naround\tO\n.\tO\n\nI\tO\nlike\tO\nthose\tO\nprograms\tB-aspectTerm\nbetter\tO\nthan\tO\nOffice\tB-aspectTerm\nand\tO\nyou\tO\ncan\tO\nsave\tO\nyour\tO\nfiles\tO\nto\tO\nbe\tO\ncompletely\tO\ncompatible\tO\nwith\tO\nthe\tO\nOffice\tB-aspectTerm\nprograms\tI-aspectTerm\nas\tO\nwell\tO\n.\tO\n\nGreat\tO\nwifi\tB-aspectTerm\ntoo\tO\n.\tO\n\nWHEN\tO\nTYPING\tB-aspectTerm\n,\tO\nLETTERS\tO\nAND\tO\nSPACES\tO\nARE\tO\nFREQUENTLY\tO\nOMITTED\tO\nREQUIRING\tO\nTHE\tO\nUSER\tO\nTO\tO\nREDO\tO\nMANY\tO\nWORDS\tO\nAND\tO\nSENTENCES\tO\n.\tO\n\nOnly\tO\na\tO\nfew\tO\ndays\tO\nafter\tO\nI\tO\nreceived\tO\nthe\tO\ncomputer\tO\nback\tO\n,\tO\nthe\tO\nscreen\tO\nfroze\tB-aspectTerm\nagain\tO\n.\tO\n\nIt\tO\nis\tO\nnot\tO\nideal\tO\nfor\tO\nchildren\tO\nbecause\tO\nof\tO\nthe\tO\ntemp\tB-aspectTerm\n.\tO\n\nsounds\tO\nlike\tO\na\tO\ntypewriter\tO\n,\tO\nbut\tO\nif\tO\nyou\tO\ncan\tO\nget\tO\npast\tO\nthat\tO\n,\tO\nthis\tO\nis\tO\na\tO\ngreat\tO\nlaptop\tO\nfor\tO\na\tO\nlittle\tO\nmoney\tO\n!\tO\n\nWhen\tO\nthis\tO\nhappened\tO\nI\tO\nwould\tO\nhave\tO\nto\tO\ncompletely\tO\npower\tO\noff\tO\nmy\tO\ncomputer\tO\nand\tO\nrestart\tO\nit\tO\n.\tO\n\nAlthough\tO\ni\tO\ndo\tO\nbelieve\tO\nthat\tO\nWindows\tB-aspectTerm\noperating\tI-aspectTerm\nsystem\tI-aspectTerm\nmay\tO\nbe\tO\nto\tO\nfault\tO\nfor\tO\nsome\tO\nof\tO\nthe\tO\nproblems\tO\n.\tO\n\nGreat\tO\nOS\tB-aspectTerm\n,\tO\nfabulous\tO\nimprovements\tO\nto\tO\nthe\tO\nexisting\tO\nline\tO\nbumping\tO\nup\tO\nthe\tO\nprocessor\tB-aspectTerm\nspeed\tI-aspectTerm\nand\tO\nadding\tO\nthe\tO\nthunderbolt\tB-aspectTerm\nport\tI-aspectTerm\n.\tO\n\nI\tO\nor\tO\nmy\tO\ndad\tO\npaid\tO\nover\tO\ntwenty\tO\nfour\tO\nhundred\tO\ndollars\tO\nfor\tO\neverything\tO\n.\tO\n\nThe\tO\nlcd\tO\nscreen\tB-aspectTerm\nstopped\tI-aspectTerm\nworking\tO\non\tO\nmine\tO\nafter\tO\n10\tO\nmonths\tO\n.\tO\n\nThat\tO\nincludes\tO\ntransferring\tO\nmy\tO\nmusic\tO\nand\tO\nmovies\tO\n.\tO\n\nImages\tB-aspectTerm\nare\tO\ncrisp\tO\nand\tO\nclean\tO\n.\tO\n\nTook\tO\nthat\tO\none\tO\nhome\tO\n,\tO\nsame\tO\nthing\tO\n.\tO\n\nI\tO\n'm\tO\ngoing\tO\nback\tO\nto\tO\nPC\tO\n.\tO\n\nGreat\tO\n,\tO\nquick\tO\nlaptop\tO\nfor\tO\nthe\tO\nmoney\tO\n.\tO\n\nalthough\tO\nits\tO\nwindows\tB-aspectTerm\nvista\tI-aspectTerm\ncompared\tO\nto\tO\nwindows\tB-aspectTerm\nxp\tI-aspectTerm\nsucks\tO\n.\tO\n\nWe\tO\nhave\tO\nhad\tO\nnumerous\tO\nproblems\tO\nwith\tO\nVista\tO\n,\tB-aspectTerm\nsuch\tO\nas\tO\nAdobe\tO\nFlash\tB-aspectTerm\nplayer\tI-aspectTerm\njust\tI-aspectTerm\nquits\tO\nand\tO\nhas\tO\nto\tO\nbe\tO\nuninstalled\tO\nand\tO\nthen\tO\nreinsalled\tO\n,\tO\nInternet\tO\nExplore\tB-aspectTerm\njust\tI-aspectTerm\nquits\tO\nand\tO\nyou\tO\nlose\tO\nwhatever\tO\nyou\tO\nwere\tO\nworking\tO\non\tO\n,\tO\nalso\tO\n,\tO\nthe\tO\nsame\tO\nWindows\tO\nupdate\tB-aspectTerm\nhas\tI-aspectTerm\nappeared\tO\non\tO\nthis\tO\ncomputer\tO\nsince\tO\nwe\tO\ngot\tO\nit\tO\nand\tO\nhas\tO\nbeen\tO\nupdated\tO\nprobably\tO\n400\tO\ntimes\tO\n,\tO\nthe\tO\nsame\tO\nupdate\tO\n.\tB-aspectTerm\n\nThe\tO\nDell\tO\nmini\tO\nwas\tO\nthe\tO\nfirst\tO\nDell\tO\nproduct\tO\nthat\tO\nI\tO\nhad\tO\never\tO\npurchased\tO\n.\tO\n\nwith\tO\nthe\tO\nswitch\tB-aspectTerm\nbeing\tO\nat\tO\nthe\tO\ntop\tO\nyou\tO\nneed\tO\nto\tO\nmemorize\tO\nthe\tO\nkey\tO\ncombination\tO\nrather\tO\nthan\tO\njust\tO\nflicking\tO\na\tO\nswitch\tB-aspectTerm\n.\tO\n\nMy\tO\nMac\tO\nhas\tO\ngone\tO\nfrom\tO\nbeing\tO\na\tO\ntrusted\tO\nfriend\tO\nto\tO\nan\tO\nadversary\tO\n.\tO\n\nOne\tO\nmore\tO\ntip\tO\n,\tO\nplease\tO\npurchase\tO\nthis\tO\nmodel\tO\nand\tO\nget\tO\na\tO\n4\tB-aspectTerm\nGB\tI-aspectTerm\nstick\tI-aspectTerm\nof\tI-aspectTerm\nRAM\tI-aspectTerm\nto\tO\nsave\tO\nyou\tO\n$\tO\n10\tO\n\nBy\tO\nweek\tO\ntwo\tO\n,\tO\nmy\tO\nlaptop\tO\nhad\tO\noverheated\tO\nand\tO\nwas\tO\ncompletely\tO\ndead\tO\neven\tO\nthough\tO\nI\tO\ndid\tO\nnot\tO\nuse\tO\nit\tO\ntoo\tO\nmuch\tO\n.\tO\n\nAnd\tO\nit\tO\nis\tO\nimpossible\tO\nto\tO\nget\tO\nthem\tO\nback\tO\nin\tO\n.\tO\n\nMy\tO\nlast\tO\nlaptop\tO\ngave\tO\nme\tO\na\tO\nconstant\tO\nbattle\tO\neven\tO\nthough\tO\nit\tO\nwas\tO\nalso\tO\ncompletely\tO\nnew\tO\n.\tO\n\nI\tO\nhave\tO\nbeen\tO\na\tO\nmac\tO\nuser\tO\nsince\tO\nthe\tO\nmid\tO\n90s\tO\n.\tO\n\nIt\tO\nhas\tO\nbein\tO\ninto\tO\nthe\tO\nshop\tO\nto\tO\nget\tO\na\tO\nnew\tO\nhardrive\tB-aspectTerm\n2\tO\ntimes\tO\nand\tO\nto\tO\nfix\tO\nthe\tO\ntouch\tB-aspectTerm\ncontrol\tI-aspectTerm\nbuttons\tI-aspectTerm\non\tO\nthe\tO\nkeyboard\tB-aspectTerm\n!\tO\n\nAfter\tO\nthe\tO\nbad\tO\nexperience\tO\nwith\tO\nthis\tO\ncomputer\tO\nwent\tO\nback\tO\nto\tO\ncompaq\tO\n.\tO\n\nFinally\tO\nafter\tO\nmonths\tO\nof\tO\nresearch\tO\nthe\tO\ndiscovered\tO\nthat\tO\nthey\tO\nmailed\tO\nit\tO\nto\tO\na\tO\nWalmart\tO\nand\tO\nthere\tO\nprobably\tO\nwould\tO\nbe\tO\nno\tO\nway\tO\nto\tO\nfind\tO\nthe\tO\nbox\tO\n.\tO\n\nIt\tO\ndoes\tO\nn't\tO\nheat\tO\nup\tO\nlike\tO\nmy\tO\nold\tO\nlaptop\tO\n.\tO\n\nI\tO\nalways\tO\nhave\tO\nused\tO\na\tO\ntower\tO\nhome\tO\nPC\tO\nand\tO\njumped\tO\nto\tO\nthe\tO\nlaptop\tO\nand\tO\nhave\tO\nbeen\tO\nvery\tO\nsatisfied\tO\nwith\tO\nits\tO\nperformance\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nsolid\tO\n.\tO\n\nBefore\tO\nI\tO\ngot\tO\nmy\tO\nmacbook\tO\n,\tO\nI\tO\nowned\tO\na\tO\nDell\tO\nlaptop\tO\n.\tO\n\nThis\tO\nlaptop\tO\nis\tO\nthe\tO\nmost\tO\namazing\tO\nlittle\tO\npeice\tO\nof\tO\nmachinery\tO\nI\tO\nhave\tO\nowned\tO\noutside\tO\nof\tO\nthe\tO\nIphone\tO\n.\tO\n\nThe\tO\ncomputer\tO\nruns\tB-aspectTerm\nvery\tO\nfast\tO\nwith\tO\nno\tO\nproblems\tO\nand\tO\nthe\tO\niLife\tB-aspectTerm\nsoftware\tI-aspectTerm\nthat\tO\ncomes\tO\nwith\tO\nit\tO\n(\tO\niPhoto\tB-aspectTerm\n,\tO\niMovie\tB-aspectTerm\n,\tO\niWeb\tB-aspectTerm\n,\tO\niTunes\tB-aspectTerm\n,\tO\nGarageBand\tB-aspectTerm\n)\tO\nis\tO\nall\tO\nvery\tO\nhelpful\tO\nas\tO\nwell\tO\n.\tO\n\nAt\tO\nfirst\tO\nit\tO\nworked\tO\nwell\tO\nfor\tO\na\tO\nmonth\tO\nor\tO\nso\tO\nthen\tO\nthe\tO\nsystem\tB-aspectTerm\nboard\tI-aspectTerm\nfailed\tO\nand\tO\nI\tO\nsend\tO\nit\tO\nin\tO\nto\tO\ntoshiba\tO\nsome\tO\ncomplaints\tO\nand\tO\nthree\tO\nweeks\tO\nlater\tO\nI\tO\nthen\tO\nreceive\tO\nmy\tO\nlaptop\tO\nback\tO\nonly\tO\nto\tO\ndiscover\tO\nthat\tO\nit\tO\nstill\tO\nhas\tO\nthe\tO\nsame\tO\nproblem\tO\nso\tO\nnow\tO\nI\tO\nhave\tO\nto\tO\nsend\tO\nit\tO\nback\tO\nagain\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\nagain\tO\n.\tO\n\nUntil\tO\nI\tO\nbought\tO\nthe\tO\nDell\tO\n,\tO\nI\tO\nthought\tO\nyou\tO\njust\tO\nlooked\tO\nfor\tO\nwhat\tO\nyou\tO\nwanted\tO\n(\tO\nsize\tO\n,\tB-aspectTerm\nsoftware\tO\n,\tB-aspectTerm\noptions\tO\n,\tO\nhardware\tO\n)\tB-aspectTerm\nand\tO\npurchase\tO\nthe\tO\nbest\tO\ndeal\tO\nyou\tO\ncould\tO\nfind\tO\n.\tO\n\nI\tO\ndo\tO\nn't\tO\nknow\tO\nhow\tO\nI\tO\ncould\tO\never\tO\nlive\tO\nwithout\tO\nmy\tO\nQousmio\tO\n.\tO\n\nIt\tO\nhas\tO\nplenty\tO\nof\tO\nmemory\tB-aspectTerm\n,\tO\nlots\tO\nof\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n,\tO\nand\tO\ngreat\tO\ngraphics\tB-aspectTerm\n.\tO\n\nIt\tO\ndid\tO\nn't\tO\ntake\tO\nme\tO\nlong\tO\nto\tO\nget\tO\nswitched\tO\nover\tO\nto\tO\nthe\tO\nMac\tO\ncomputer\tO\nprograms\tB-aspectTerm\nand\tO\nnavigation\tB-aspectTerm\n-\tO\nit\tO\n's\tO\nbeen\tO\njust\tO\nfine\tO\nand\tO\nlike\tO\nthe\tO\nway\tO\nthis\tO\nlaptop\tO\nfunctions\tO\nmuch\tO\nbetter\tO\n.\tO\n\nIt\tO\nlasted\tO\nfor\tO\nmany\tO\nyears\tO\nof\tO\ntravel\tO\n,\tO\nkids\tO\nand\tO\nabuse\tO\nand\tO\nif\tO\nI\tO\nfired\tO\nit\tO\nup\tO\ntoday\tO\n,\tO\nit\tO\nwould\tO\nwork\tO\n.\tO\n\nbeen\tO\na\tO\nPC\tO\nuser\tO\nfor\tO\nmany\tO\n,\tO\nmany\tO\nyears\tO\n.\tO\n\nI\tO\nhave\tO\nnever\tO\nhad\tO\nany\tO\nissues\tO\nor\tO\nproblems\tO\nwith\tO\nmy\tO\nMacBook\tO\nPro\tO\nso\tO\nfar\tO\n,\tO\nand\tO\nit\tO\nis\tO\nstill\tO\nas\tO\nfast\tO\nas\tO\nit\tO\nwas\tO\nwhen\tO\nI\tO\nfirst\tO\nbought\tO\nit\tO\n.\tO\n\nIt\tO\nfreezes\tO\n,\tO\nand\tO\nit\tO\nalways\tO\nshows\tO\nthat\tO\nthere\tO\nis\tO\nan\tO\nerror\tO\n,\tO\nso\tO\nI\tO\nhave\tO\nto\tO\nrestart\tO\nit\tO\na\tO\nfew\tO\ntimes\tO\nevery\tO\ntime\tO\nI\tO\nuse\tO\nit\tO\n.\tO\n\nHowever\tO\n,\tO\nmy\tO\ngirlfriend\tO\nrealized\tO\nthat\tO\nthe\tO\nnetbook\tO\n's\tO\nhinge\tB-aspectTerm\nis\tO\na\tO\nbit\tO\nloose\tO\n(\tO\nwhen\tO\nyou\tO\nopen\tO\nor\tO\nclose\tO\nthe\tO\nLCD\tB-aspectTerm\n)\tO\n.\tO\n\nMy\tO\nproblem\tO\nwas\tO\nwith\tO\nDELL\tB-aspectTerm\nCustomer\tI-aspectTerm\nService\tI-aspectTerm\n.\tO\n\nThere\tO\nare\tO\nso\tO\nmany\tO\nthings\tO\nwrong\tO\nwith\tO\nthis\tO\nproduct\tO\n,\tO\nit\tO\njust\tO\nmakes\tO\nme\tO\nwant\tO\nto\tO\nset\tO\nmy\tO\nself\tO\non\tO\nfire\tO\n!\tO\n\nIt\tO\nis\tO\nnot\tO\neven\tO\na\tO\nyear\tO\nold\tO\nyet\tO\n,\tO\nso\tO\nI\tO\nwould\tO\ndefinitely\tO\nnot\tO\nrecommend\tO\nit\tO\nto\tO\nanyone\tO\n.\tO\n\nAmazing\tO\nmachine\tO\n.\tO\n\nI\tO\ndo\tO\nn't\tO\ndo\tO\nany\tO\nhigh\tO\ntech\tO\nstuff\tO\non\tO\nit\tO\n,\tO\njust\tO\nwrite\tO\npapers\tO\n,\tO\ncheck\tO\nmail\tO\n,\tO\nand\tO\nsometimes\tO\nplay\tO\ngames\tO\n,\tO\nso\tO\nI\tO\nca\tO\nn't\tO\nreccomend\tO\nit\tO\nif\tO\nyou\tO\nare\tO\nin\tO\nthe\tO\ncomputer\tO\nfield\tO\n.\tO\n\nNewegg\tO\n's\tO\nRMA\tB-aspectTerm\nservice\tI-aspectTerm\nwas\tO\ngreat\tO\nas\tO\nalways\tO\n,\tO\nI\tO\ncontacted\tO\nthem\tO\nlate\tO\nFriday\tO\nnight\tO\n,\tO\nand\tO\nthey\tO\nissued\tO\nme\tO\nan\tO\nRMA\tO\nnumber\tO\nand\tO\na\tO\nPrePaid\tO\nUPS\tO\nshipping\tO\nlabel\tO\nthe\tO\nvery\tO\nnext\tO\nmorning\tO\non\tO\nSaturday\tO\n.\tO\n\nI\tO\n'm\tO\nvery\tO\nimpressed\tO\n.\tO\n\nDell\tO\nsucks\tO\n\nDesign\tB-aspectTerm\n:\tO\nvery\tO\ndurable\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\ngo\tO\nfrom\tO\none\tO\nkeyboard\tB-aspectTerm\nto\tO\nanother\tO\n.\tO\n\nI\tO\nspoke\tO\nto\tO\n4\tO\ndifferent\tO\npeople\tO\nand\tO\nwas\tO\ntold\tO\nthey\tO\nneeded\tO\nto\tO\ntransfer\tO\nme\tO\nto\tO\na\tO\n5th\tO\nperson\tO\n!\tO\n\nThe\tO\nMac\tO\nBook\tO\nPro\tO\nperforms\tO\nflawlessly\tO\n.\tO\n\nHas\tO\na\tO\n5\tO\n-\tO\n6\tO\nhour\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nMy\tO\nONLY\tO\nissues\tO\nare\tO\n:\tO\n1\tO\n)\tO\nthe\tO\nscreen\tB-aspectTerm\n/\tI-aspectTerm\nvideo\tI-aspectTerm\nresolution\tI-aspectTerm\nwo\tO\nn't\tO\nincrease\tO\nto\tO\na\tO\nhigher\tO\nresolution\tB-aspectTerm\nthen\tO\n1024\tO\nx\tO\n60\tO\n\nI\tO\nrun\tO\nDreamweaver\tB-aspectTerm\n,\tO\nFinal\tB-aspectTerm\nCut\tI-aspectTerm\nPro\tI-aspectTerm\n7\tI-aspectTerm\n,\tO\nPhotoshop\tB-aspectTerm\n,\tO\nSafari\tB-aspectTerm\n,\tO\nFirefox\tB-aspectTerm\n,\tO\nMSN\tB-aspectTerm\nMessenger\tI-aspectTerm\nand\tO\na\tO\nfew\tO\nother\tO\napplications\tB-aspectTerm\nconstantly\tO\nat\tO\nthe\tO\nsame\tO\ntime\tO\n.\tO\n\nI\tO\nhave\tO\nowned\tO\nmany\tO\ncomputers\tO\nand\tO\nlaptops\tO\n.\tO\n\nI\tO\nrecently\tO\npurchased\tO\nthe\tO\nmini\tO\nand\tO\nabsolutely\tO\nlove\tO\nit\tO\n!\tO\n\nDoes\tO\na\tO\ngreat\tO\njob\tO\nwith\tO\nvideo\tO\nshot\tO\non\tO\na\tO\nCanon\tO\n5D\tO\nMKII\tO\n.\tO\n\nI\tO\nwas\tO\ntold\tO\nby\tO\nmany\tO\nthat\tO\nit\tO\nwas\tO\na\tO\ngreat\tO\ncomputer\tO\n,\tO\nbut\tO\nwe\tO\ngot\tO\none\tO\nof\tO\nthese\tO\n,\tO\nand\tO\nit\tO\nworked\tO\ngreat\tO\nfor\tO\none\tO\nyear\tO\n,\tO\nand\tO\nas\tO\nsoon\tO\nas\tO\nthe\tO\nwarrenty\tO\nwas\tB-aspectTerm\nup\tO\n,\tO\nthen\tO\nit\tO\ngot\tO\nreally\tO\nbad\tO\n.\tO\n\nI\tO\nve\tO\nhad\tO\nto\tO\ncall\tO\ntech\tB-aspectTerm\nsupport\tI-aspectTerm\nmany\tO\ntimes\tO\n.\tO\n\nThe\tO\nApple\tB-aspectTerm\napplications\tI-aspectTerm\n(\tO\nex.iPhoto\tO\n)\tO\nare\tO\nfun\tO\n,\tO\neasy\tO\n,\tO\nand\tO\nreally\tO\ncool\tO\nto\tO\nuse\tO\n(\tO\nunlike\tO\nthe\tO\ncompetition\tO\n)\tO\n!\tO\n\nYes\tO\n,\tO\nI\tO\nhave\tO\nit\tO\non\tO\nthe\tO\nhighest\tO\navailable\tO\nsetting\tO\n.\tO\n\nNot\tO\nto\tO\nmention\tO\nit\tO\nhas\tO\nshit\tO\ngigs\tB-aspectTerm\n.\tO\n\nHieroglyphics\tO\nare\tO\nquite\tO\ncommon\tO\n.\tO\n\nThis\tO\nworked\tO\njust\tO\nfine\tO\n.\tO\n\nI\tO\npaid\tO\nfor\tO\nextra\tO\nmemory\tB-aspectTerm\nand\tO\nthe\tO\n17-inch\tB-aspectTerm\nscreen\tI-aspectTerm\n,\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\nline\tO\nDVD\tB-aspectTerm\nand\tO\nCD\tB-aspectTerm\nburners\tI-aspectTerm\n.\tO\n\nIts\tO\npretty\tO\nfast\tO\nand\tO\ndoes\tO\nnot\tO\nhave\tO\nhiccups\tO\nwhile\tO\nI\tO\nam\tO\nusing\tO\nit\tO\nfor\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\n,\tO\nuploading\tB-aspectTerm\nphotos\tI-aspectTerm\n,\tO\nwatching\tB-aspectTerm\nmovies\tI-aspectTerm\n(\tO\n720p\tO\n)\tO\non\tO\noccasion\tO\nand\tO\ncreating\tB-aspectTerm\npresentations\tI-aspectTerm\n.\tO\n\nI\tO\nwas\tO\nso\tO\nhappy\tO\nwith\tO\nmy\tO\nnew\tO\nMac\tO\n.\tO\n\nQuality\tB-aspectTerm\nDisplay\tI-aspectTerm\nI\tO\nlove\tO\nHP\tO\n,\tO\n,\tO\nit\tO\n's\tO\nthe\tO\nonly\tO\ncomputer\tO\n/\tO\nprinter\tO\nwe\tO\nwill\tO\nbuy\tO\n.\tO\n\nDespite\tO\nthe\tO\ninconvenient\tO\nweight\tB-aspectTerm\n,\tO\nI\tO\nopted\tO\nfor\tO\nthe\tO\n12\tB-aspectTerm\ncell\tI-aspectTerm\nbattery\tI-aspectTerm\n.\tO\n\nMy\tO\nMacBook\tO\nis\tO\nfaster\tO\nthan\tO\nany\tO\ncomparable\tO\nPC\tO\n.\tO\n\nThe\tO\ncase\tB-aspectTerm\nis\tO\ncarved\tO\nout\tO\nof\tO\na\tO\nsingle\tO\nblock\tO\nof\tO\naluminum\tO\n.\tO\n\nI\tO\n'm\tO\nvery\tO\nhappy\tO\nwith\tO\nthis\tO\nmachine\tO\n!\tO\n\nI\tO\ndo\tO\nnot\tO\nrecommend\tO\nthis\tO\ncompany\tO\nor\tO\ntheir\tO\nproducts\tO\n!\tO\n!\tO\n!\tO\n!\tO\n\nI\tO\nlike\tO\nthis\tO\nmachine\tO\nbecause\tO\nits\tO\nvery\tO\nlightweight\tO\n...\tO\n\nFirst\tO\nit\tO\nburned\tO\nor\tO\nfused\tO\nthe\tO\npower\tO\nadapter\tB-aspectTerm\nplug\tI-aspectTerm\n.\tI-aspectTerm\n\nthe\tO\nfeatures\tB-aspectTerm\nare\tO\ngreat\tO\n,\tO\nthe\tO\nonly\tO\nthing\tO\nit\tO\nneeds\tO\nis\tO\nbetter\tO\nspeakers\tB-aspectTerm\n.\tO\n\nIt\tO\nwas\tO\nstill\tO\nworking\tO\n,\tO\nbut\tO\nthere\tO\nwas\tO\nnothing\tO\non\tO\nthe\tO\nscreen\tB-aspectTerm\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\nand\tO\nfound\tO\nits\tO\nTAB\tB-aspectTerm\nis\tO\nnot\tO\nfunctioning\tO\n.\tO\n\nToshiba\tO\nis\tO\naware\tO\nof\tO\nthe\tO\nissue\tO\nbut\tO\nunless\tO\nthe\tO\nextended\tO\nwarrenty\tB-aspectTerm\nis\tI-aspectTerm\nbought\tO\nToshiba\tO\nwill\tO\ndo\tO\nnothing\tO\nabout\tO\nit\tO\n.\tO\n\nHP\tO\nsaid\tO\nI\tO\nhad\tO\ndone\tO\nthe\tO\ndamage\tO\n.\tO\n\n-Called\tO\nheadquarters\tO\nagain\tO\n,\tO\nthey\tO\nreport\tO\nthat\tO\nTFT\tB-aspectTerm\npanel\tI-aspectTerm\nis\tO\nbroken\tO\n,\tO\nshould\tO\nbe\tO\nfixed\tO\nby\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nweek\tO\n(\tO\nweek\tO\n3\tO\n)\tO\n.\tO\n\nNavigation\tB-aspectTerm\nthrough\tO\nthe\tO\ncomputer\tO\nis\tO\nfar\tO\nsuperior\tO\ncompared\tO\nto\tO\nWindows\tB-aspectTerm\noperating\tI-aspectTerm\nsystems\tI-aspectTerm\n,\tO\nas\tO\nwell\tO\n.\tO\n\nI\tO\nwould\tO\nrecommend\tO\nthis\tO\nproduct\tO\n.\tO\n\nIf\tO\nI\tO\nhad\tO\nto\tO\nbuy\tO\nanother\tO\ncomputer\tO\n,\tO\nI\tO\nwould\tO\nmost\tO\ndefinetly\tO\nbuy\tO\nan\tO\nacer\tO\none\tO\ncomputer\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nframed\tO\nby\tO\nhalf-\tO\nto\tO\na\tO\nfull\tO\n-\tO\ninch\tO\nmargin\tO\nthat\tO\nis\tO\nobviously\tO\nunnecessary\tO\n,\tO\nreduces\tO\nthe\tO\nscreen\tB-aspectTerm\nsize\tI-aspectTerm\nand\tO\nincreases\tO\nthe\tO\nbulk\tB-aspectTerm\n.\tO\n\nThough\tO\nthe\tO\npicture\tB-aspectTerm\n,\tO\nvideo\tB-aspectTerm\n,\tO\nand\tO\nmusic\tB-aspectTerm\nsoftware\tI-aspectTerm\nis\tO\nnowhere\tO\nclose\tO\nto\tO\nprofessional\tO\ngrade\tO\nsoftware\tB-aspectTerm\nI\tO\nm\tO\nused\tO\nto\tO\n(\tO\nCS5\tO\n)\tO\nbut\tO\ndoes\tO\nthe\tO\njob\tO\nfor\tO\nbeginner\tO\nand\tO\neven\tO\nintermediate\tO\nmedia\tO\ndesigners\tO\n.\tO\n\nI\tO\npreviously\tO\nowned\tO\nan\tO\nHP\tO\ndesktop\tO\nand\tO\na\tO\nDell\tO\nlaptop\tO\n.\tO\n\nEverything\tO\nelse\tO\njust\tO\ninstall\tO\nand\tO\ngo\tO\n.\tO\n\nThis\tO\nthing\tO\nis\tO\na\tO\nlemon\tO\n.\tO\n\nMy\tO\nlaptop\tO\nis\tO\nalmost\tO\n2yrs\tO\nold\tO\nand\tO\nI\tO\nhave\tO\nnever\tO\nhad\tO\nany\tO\nproblems\tO\nwith\tO\nit\tO\n.\tO\n\nAll\tO\nthe\tO\ncustomers\tO\nthat\tO\ncome\tO\nin\tO\nhate\tO\nDell\tO\n.\tO\n\nWe\tO\nnow\tO\nown\tO\ntwo\tO\nof\tO\nthese\tO\n,\tO\nidentical\tO\n.\tO\n\nI\tO\n've\tO\nalready\tO\nrecommended\tO\nthis\tO\nlaptop\tO\nto\tO\na\tO\nfriend\tO\nwho\tO\neye'd\tO\nthe\tO\ncomputer\tO\nwhen\tO\nI\tO\ntook\tO\nit\tO\nout\tO\nof\tO\nmy\tO\nbag\tO\n.\tO\n\nI\tO\nenjoy\tO\nvery\tO\nmuch\tO\nmy\tO\nnew\tO\nToshiba\tO\n,\tO\npurchased\tO\nspecifially\tO\nfor\tO\nattending\tO\nonline\tO\nschooling\tO\n.\tO\n\nOnce\tO\nyou\tO\ngo\tO\nMac\tO\n,\tO\nyou\tO\nca\tO\nn't\tO\ngo\tO\nback\tO\n!\tO\n\nI\tO\nbrought\tO\nthis\tO\nlaptop\tO\nlast\tO\nfriday\tO\n,\tO\nand\tO\noriginally\tO\nit\tO\nworked\tO\nfantastic\tO\n.\tO\n\nThe\tO\nmuch\tO\nlauded\tO\ncombined\tB-aspectTerm\ntouch\tI-aspectTerm\npad\tI-aspectTerm\nand\tI-aspectTerm\nclicker\tI-aspectTerm\nis\tO\na\tO\nnightmare\tO\n.\tO\n\nThe\tO\nUnibody\tB-aspectTerm\nconstruction\tI-aspectTerm\nis\tO\nsolid\tO\n,\tO\nsleek\tO\nand\tO\nbeautiful\tO\n.\tO\n\nThey\tO\n're\tO\neasy\tO\n,\tO\nfun\tO\n,\tO\npowerful\tO\nand\tO\nwill\tO\nlast\tO\na\tO\nlong\tO\ntime\tO\n.\tO\n\nI\tO\nWANT\tO\nMY\tO\nL505-s5988\tO\nBACK\tO\n!\tO\n\nI\tO\nlet\tO\nmy\tO\nfriend\tO\nborrow\tO\nit\tO\n,\tO\nand\tO\nshe\tO\nknows\tO\nnothing\tO\nabout\tO\ncomputers\tO\n,\tO\nand\tO\nshe\tO\nused\tO\nit\tO\nwith\tO\nease\tO\n.\tO\n\nThis\tO\nMacBook\tO\nis\tO\nan\tO\noutstanding\tO\nproduct\tO\nwith\tO\ngreat\tO\nvalue\tB-aspectTerm\n.\tO\n\nIf\tO\nthat\tO\nis\tO\nthe\tO\ncase\tO\nfor\tO\nyou\tO\n,\tO\nI\tO\nwould\tO\nsuggest\tO\na\tO\npull\tO\n-\tO\nbehind\tO\nsolution\tO\nwhen\tO\nlooking\tO\nat\tO\ncases\tO\n.\tO\n\nI\tO\nhad\tO\nto\tO\nre\tO\n-\tO\ninstall\tO\nWindows\tB-aspectTerm\nwithin\tO\ntwo\tO\nweeks\tO\nof\tO\nthe\tO\npurchase\tO\nand\tO\nsoon\tO\ndiscovered\tO\ncracks\tO\nin\tO\nthe\tO\nscreen\tB-aspectTerm\nhinges\tI-aspectTerm\n.\tO\n\nA\tO\nSECOND\tO\nPROBLEM\tO\nINVOLVES\tO\nTHE\tO\nBATTERY\tB-aspectTerm\nWHICH\tO\nIS\tO\nADVERTISED\tO\nAS\tO\nHAVING\tO\nA\tO\nSTORAGE\tB-aspectTerm\nLIFE\tI-aspectTerm\nOF\tO\n11\tO\nHOURS\tO\nBUT\tO\nWHEN\tO\nFULLY\tO\nCHARGED\tO\nSHOWS\tO\nONLY\tO\n7\tO\nHOURS\tO\nOF\tO\nSERVICE\tB-aspectTerm\n.\tO\n\nand\tO\nplenty\tO\nof\tO\nstorage\tB-aspectTerm\nwith\tO\n250\tO\ngb(though\tO\nI\tO\nwill\tO\nupgrade\tO\nthis\tO\nand\tO\nthe\tO\nram\tB-aspectTerm\n..\tO\n)\tO\n\nI\tO\nhad\tO\nto\tO\ncall\tO\nApple\tO\n19\tO\ntimes\tO\n(\tO\neach\tO\ntime\tO\n40\tO\nto\tO\n75\tO\nminutes\tO\non\tO\nthe\tO\nphone\tO\n)\tO\n,\tO\nand\tO\ntake\tO\nit\tO\nto\tO\ntheir\tO\nstore\tO\nfor\tO\nevaluations\tO\n,\tO\nand\tO\ndiagnostics\tO\n,\tO\n5\tO\ntimes\tO\n.\tO\n\nNo\tO\ntemporary\tO\nreplacement\tO\n,\tO\nthey\tO\nare\tO\nout\tO\nof\tO\nreplacements\tO\nbecause\tO\n\"\tO\nmany\tO\ncomputers\tO\nhad\tO\nproblems\tO\nwith\tO\nthe\tO\nNvidia\tB-aspectTerm\nchipset\"-Inquired\tI-aspectTerm\nstatus\tO\nof\tO\nrepair\tO\n.\tO\n\nI\tO\ntook\tO\nit\tO\nto\tO\nfriend\tO\nwho\tO\ntemporarily\tO\nfixed\tO\nit\tO\nand\tO\nI\tO\nfinally\tO\npaid\tO\nabout\tO\n1500\tO\nfor\tO\nthe\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\n.\tO\n\nI\tO\nrespond\tO\nthat\tO\nI\tO\ndo\tO\nnot\tO\nhave\tO\nthe\tO\nold\tO\ncomputer\tO\n...\tO\n\nI\tO\nhomeschool\tO\nmy\tO\nkids\tO\nand\tO\nwith\tO\nthis\tO\nnetbook\tO\nnext\tO\nto\tO\nmy\tO\ndesk\tO\nwe\tO\nget\tO\nto\tO\nteaching\tO\nand\tO\nillustrating\tO\nwithout\tO\nskipping\tO\na\tO\nbeat\tO\n.\tO\n\nPrograms\tB-aspectTerm\nwould\tO\ncrash\tO\nall\tO\nthe\tO\ntime\tO\n,\tO\nand\tO\nit\tO\nturned\tO\nout\tO\nto\tO\nbe\tO\na\tO\nvery\tO\nunstable\tO\n,\tO\nunreliable\tO\nlaptop\tO\nfor\tO\nme\tO\n.\tO\n\nI\tO\nBOUGHT\tO\nTHIS\tO\nLAP\tO\nTOP\tO\nAND\tO\nTHE\tO\nCHARGE\tB-aspectTerm\nTIME\tI-aspectTerm\nDOSEN'T\tO\nLAST\tO\nAS\tO\nLONG\tO\nAS\tO\nTHEY\tO\nSAY\tO\nIT\tO\nWILL\tO\nMORE\tO\nLIKE\tO\n2\tO\nHOURS\tO\n\nAlso\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nsize\tB-aspectTerm\nand\tO\nconsistancy\tB-aspectTerm\nof\tO\nthe\tO\nlaptop\tO\ncomputer\tO\n,\tO\nsome\tO\nwebsites\tO\nwould\tO\nn't\tO\neven\tO\nattempt\tO\nto\tO\nwork\tO\non\tO\nthe\tO\ncomputer\tO\nbecause\tO\nof\tO\nbrowser\tO\nproblems\tO\n.\tO\n\nI\tO\nwork\tO\nwith\tO\nkids\tO\nand\tO\nthey\tO\nlove\tO\nmaking\tO\nshort\tO\nvideos\tO\non\tO\nthere\tO\n.\tO\n\nIt\tO\nis\tO\nvery\tO\ndurable\tO\n,\tO\nI\tO\nam\tO\npretty\tO\nrough\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\nelectronics\tO\nand\tO\nit\tO\nhas\tO\ntaken\tO\nit\tO\nall\tO\nwith\tO\nno\tO\nreprecutions\tO\nyet\tO\n.\tO\n\nthe\tO\nkey\tB-aspectTerm\nbindings\tI-aspectTerm\ntake\tO\na\tO\nlittle\tO\ngetting\tO\nused\tO\nto\tO\n,\tO\nbut\tO\nhave\tO\nloved\tO\nthe\tO\nMacbook\tO\nPro\tO\n.\tO\n\nKeyboard\tB-aspectTerm\nis\tO\nreasonable\tO\nsize\tB-aspectTerm\n.\tO\n\nInstead\tO\nit\tO\nis\tO\nsitting\tO\nin\tO\nWest\tO\nVerginia\tO\nwaiting\tO\nfor\tO\nUPS\tO\nto\tO\ntake\tO\ntwo\tO\ndays\tO\nto\tO\nsend\tO\nMe\tO\na\tO\nbox\tO\nand\tO\nTwo\tO\ndays\tO\nfor\tO\nthem\tO\nto\tO\nship\tO\nthe\tO\ncomputer\tO\nsome\tO\n691\tO\nmiles\tO\nby\tO\nair\tO\n?\tO\nto\tO\nLouisville\tO\nKy.\tO\n\nI\tO\n'm\tO\nnow\tO\ntrying\tO\nto\tO\ndecide\tO\non\tO\nanother\tO\nDell\tO\nmodel\tO\n.\tO\n\nI\tO\nfind\tO\nmyself\tO\nusing\tO\nthe\tO\n10-key\tB-aspectTerm\nmore\tO\nthan\tO\nI\tO\nthought\tO\nI\tO\nwould\tO\n.\tO\n\nThe\tO\nMacbook\tO\nis\tO\na\tO\nfantastic\tO\nlaptop\tO\n.\tO\n\nFan\tB-aspectTerm\nnoise\tO\n:\tO\nThe\tO\nfan\tB-aspectTerm\nmade\tO\na\tO\nconstant\tO\nhissing\tO\nnoise\tO\nin\tO\nthe\tO\nbackground\tO\n.\tO\n\nI\tO\nbelieve\tO\nthis\tO\nis\tO\nbecause\tO\nI\tO\nwas\tO\nmore\tO\nactive\tO\nthan\tO\nthe\tO\naverage\tO\nuser\tO\n,\tO\nmeaning\tO\nI\tO\naverage\tO\nabout\tO\nthree\tO\n\"\tO\ntabs\tO\n\"\tO\n.\tO\n\nBest\tO\nBuy\tO\nRocks\tO\n!\tO\n\nA\tO\ncouple\tO\nthings\tO\nyou\tO\nshould\tO\nknow\tO\n:\tO\n\nbought\tO\nthe\tO\nfirst\tO\nasus\tO\nlaptop\tO\nin\tO\nsan\tO\nfrancisco\tO\n,\tO\nreturned\tO\nit\tO\nin\tO\nsanta\tO\nmaria\tO\n,\tO\nthinking\tO\nit\tO\nwas\tO\njust\tO\na\tO\nproblem\tO\nwith\tO\nthat\tO\ncomputer\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nbright\tO\nand\tO\nclear\tO\n,\tO\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nis\tO\nsolid\tO\nand\tO\nfriendly\tO\nto\tO\na\tO\nnovice\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n.1\tO\nghz\tO\nfaster\tO\nprocessor\tB-aspectTerm\nand\tO\na\tO\nstock\tO\n500\tB-aspectTerm\ngb\tI-aspectTerm\nhard\tI-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nThe\tO\nfeature\tB-aspectTerm\nare\tO\ngood\tO\nenough\tO\nfor\tO\nwhat\tO\nI\tO\nneed\tO\n.\tO\n\nAll\tO\nthe\tO\nyada\tO\n-\tO\nyada\tO\n.\tO\n\nFinally\tO\n,\tO\nthe\tO\nbiggest\tO\nproblem\tO\nhas\tO\nbeen\tO\ntech\tB-aspectTerm\nsupport\tI-aspectTerm\n.\tO\n\nthis\tO\nlaptop\tO\nis\tO\ngreat\tO\nfor\tO\nwork\tO\nand\tO\ndoing\tO\nmy\tO\npictures\tO\n.\tO\n\nI\tO\nhad\tO\nthe\tO\ncomputer\tO\nfor\tO\na\tO\nfull\tO\nyear\tO\nand\tO\nit\tO\nwas\tO\na\tO\nnew\tO\ncomputer\tO\n.\tO\n\n\"\tO\nThis\tO\nis\tO\nn't\tO\na\tO\nbig\tO\ndeal\tO\n,\tO\nI\tO\nhave\tO\nn't\tO\nnoticed\tO\nthe\tO\nissue\tO\nwith\tO\nDVDs\tO\nor\tO\nother\tO\nmedia\tO\n,\tO\nonly\tO\nthrough\tO\nUSB\tB-aspectTerm\noutput\tI-aspectTerm\n.\tO\n\nI\tO\nlove\tO\nit\tO\n!\tO\n\nWith\tO\nWindows\tO\nlaptops\tO\na\tO\nwireless\tB-aspectTerm\nmouse\tI-aspectTerm\nis\tO\nan\tO\nabsolute\tO\nmust\tO\n.\tO\n\n(\tO\nI\tO\nhad\tO\nbeen\tO\na\tO\nWindows\tB-aspectTerm\n/\tO\nLinux\tB-aspectTerm\nuser\tO\nbefore\tO\nthis\tO\n)\tO\nI\tO\nlove\tO\nthe\tO\nsize\tB-aspectTerm\nbecause\tO\nthe\tO\nscreen\tB-aspectTerm\nis\tO\nbig\tO\nenough\tO\nfor\tO\nwhat\tO\nI\tO\nuse\tO\nit\tO\nfor\tO\n(\tO\nInternet\tO\n,\tO\nartwork\tO\n)\tO\n,\tO\nand\tO\nyet\tO\nit\tO\nis\tO\nsmall\tO\nenough\tO\nto\tO\nbe\tO\nreasonably\tO\nportable\tO\n.\tO\n\nBut\tO\nif\tO\nyou\tO\n're\tO\nwilling\tO\nto\tO\npay\tO\nanother\tO\n200\tO\ndollar\tO\nfor\tO\na\tO\nwindows\tB-aspectTerm\ndisc\tI-aspectTerm\n.\tO\n\nVery\tO\ngood\tO\nquality\tB-aspectTerm\nand\tO\nwell\tO\nmade\tO\n.\tO\n\nI\tO\nbought\tO\na\tO\nLogitech\tO\ndesktop\tO\nset\tO\nin\tO\nanticipation\tO\nfor\tO\nusing\tO\nwith\tO\nthe\tO\nMBP\tO\n,\tO\nbut\tO\nI\tO\nuse\tO\nthe\tO\ntouchpad\tB-aspectTerm\n90\tO\n%\tO\nof\tO\nthe\tO\ntime\tO\n.\tO\n\nWhen\tO\ncalling\tO\nDell\tO\nfor\tO\nhelp\tO\n,\tO\nreurn\tO\n,\tO\nor\tO\na\tO\nnew\tO\ncomputer\tO\nthey\tO\nwere\tO\nnot\tO\nuseful\tO\nand\tO\nleft\tO\nit\tO\nup\tO\nto\tO\nmyself\tO\nto\tO\nfigure\tO\nout\tO\nwhat\tO\nto\tO\ndo\tO\nwith\tO\nit\tO\n.\tO\n\nTwo\tO\nof\tO\nthe\tO\ntimes\tO\nwas\tO\nin\tO\none\tO\nmonth\tO\n.\tO\n\nSo\tO\nneedless\tO\nto\tO\nday\tO\n,\tO\nI\tO\n'm\tO\nnot\tO\nhappy\tO\n.\tO\n\nmy\tO\nniece\tO\nand\tO\nnephew\tO\nhave\tO\nplayed\tO\na\tO\nfew\tO\nweb\tO\ngames\tO\nand\tO\nit\tO\nruns\tO\nanything\tO\nthat\tO\ndoes\tO\nn't\tO\nrequire\tO\na\tO\ndedicated\tO\nvideo\tB-aspectTerm\ncard\tI-aspectTerm\n.\tO\n\nAlthough\tO\nI\tO\nwas\tO\npromised\tO\nabout\tO\n10\tO\nhours\tO\n,\tO\nI\tO\nfound\tO\nmyself\tO\nto\tO\na\tO\nlimited\tO\n7\tO\nhours\tO\n(\tO\nwhich\tO\nis\tO\nstill\tO\namazing\tO\n)\tO\n.\tO\n\nIt\tO\nhad\tO\nthe\tO\nfull\tO\nsized\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\nwith\tO\n2\tO\nbuttons\tO\ninstead\tO\nof\tO\njust\tO\none\tO\n.\tO\n\nIt\tO\nwas\tO\nalso\tO\ncheaper\tO\nthan\tO\nthe\tO\nPro\tO\nwhich\tO\nmade\tO\nit\tO\neven\tO\nmore\tO\nappealing\tO\nto\tO\nme\tO\n.\tO\n\nTypically\tO\n,\tO\nwhen\tO\nI\tO\npurchase\tO\na\tO\nnew\tO\nlaptop\tO\nI\tO\nalways\tO\nend\tO\nup\tO\nusing\tO\nan\tO\nexternal\tB-aspectTerm\nmouse\tI-aspectTerm\nfor\tO\nconvenience\tO\n.\tO\n\nConsumer\tO\nReport\tO\nrecommended\tO\nToshiba\tO\n.\tO\n\nNeedless\tO\nto\tO\nsay\tO\nI\tO\ntold\tO\nthem\tO\nNo\tO\nand\tO\nhave\tO\na\tO\nnice\tO\nday\tO\nand\tO\nhung\tO\nup\tO\n!\tO\n\nIt\tO\nwas\tO\nsuper\tO\neasy\tO\nto\tO\nset\tB-aspectTerm\nup\tI-aspectTerm\nand\tO\nIs\tO\nreally\tO\neasy\tO\nto\tO\nget\tO\nused\tO\nto\tO\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nthat\tO\ncan\tO\nbe\tO\nupdated\tO\nis\tO\nthe\tO\nvideo\tB-aspectTerm\n,\tO\nother\tO\nthan\tO\nthat\tO\nyou\tO\n're\tO\nall\tO\nset\tO\n.\tO\n\nIt\tO\nwas\tO\nn't\tO\nworth\tO\nit\tO\n.\tO\n\nIts\tO\na\tO\ngood\tO\nlaptop\tO\nfor\tO\nits\tO\nvalue\tB-aspectTerm\n.\tO\n\nANd\tO\nI\tO\nbabyed\tO\nthe\tO\nheck\tO\nout\tO\nof\tO\nit\tO\njust\tO\none\tO\nday\tO\nwhen\tO\ni\tO\nopened\tO\nit\tO\nturned\tO\nit\tO\non\tO\nwent\tO\nto\tO\nclick\tO\nand\tO\nit\tO\nwas\tO\nbroke\tO\n.\tO\n\nProbbly\tO\nthe\tO\nworst\tO\ndecision\tO\nwe\tO\never\tO\nmade\tO\n!\tO\n\nThen\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nfailed\tO\n;\tO\n\nThis\tO\ncomputer\tO\nliterally\tO\ntakes\tO\nabout\tO\nfive\tO\nminutes\tO\nto\tO\nstart\tO\nup\tO\nand\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nwithout\tO\nit\tO\ncrawling\tO\nand\tO\nI\tO\nDO\tO\nmean\tO\ncrawling\tO\n.\tO\n\nI\tO\nhad\tO\nless\tO\nproblems\tO\n.\tO\n\nIt\tO\nwill\tO\nbe\tO\nreturned\tO\nin\tO\nthe\tO\nstate\tO\nto\tO\nwhich\tO\nit\tO\nwas\tO\nshipped\tO\nMichigan\tO\n.\tO\n\nPlain\tO\nand\tO\nsimple\tO\n,\tO\nit(laptop\tO\n)\tO\nruns\tB-aspectTerm\ngreat\tO\nand\tO\nloads\tB-aspectTerm\nfast\tO\n.\tO\n\nThis\tO\nmachine\tO\nrocks\tO\n!\tO\n\nof\tO\ncourse\tO\nmy\tO\nwarranty\tB-aspectTerm\nruns\tO\nout\tO\nnext\tO\nmonth\tO\n.\tO\n\nMy\tO\nnext\tO\nlaptop\tO\nwill\tO\nalso\tO\nbe\tO\na\tO\nMac\tO\n!\tO\n\nBut\tO\nnot\tO\nin\tO\nthis\tO\ncase\tO\n.\tO\n\ntaking\tO\nnotes\tO\n,\tO\nresearch\tO\n,\tO\nan\tO\nonline\tO\nclass\tO\nand\tO\nsuch\tO\nand\tO\ndid\tO\nn't\tO\nwant\tO\nto\tO\nspend\tO\ntoo\tO\nmuch\tO\non\tO\nmy\tO\nfirst\tO\nmachine\tO\n.\tO\n\nThe\tO\ncapabilities\tO\nusing\tO\nthat\tO\nprogram\tB-aspectTerm\nalone\tO\nmade\tO\nme\tO\nwant\tO\na\tO\nMac\tO\n.\tO\n\nWhen\tO\nI\tO\ngot\tO\nthis\tO\nlaptop\tO\nin\tO\n2007\tO\nto\tO\nhelp\tO\nme\tO\nwith\tO\nschool\tO\n,\tO\nI\tO\nhad\tO\na\tO\nhard\tO\ntime\tO\nfrom\tO\nbeginning\tO\n.\tO\n\nI\tO\ndo\tO\nnot\tO\nknow\tO\nfor\tO\nsure\tO\n.\tO\n\nNo\tO\nmachine\tO\nhas\tO\ncome\tO\nremotely\tO\nclose\tO\nto\tO\ncausing\tO\nas\tO\nmany\tO\nproblems\tO\n.\tO\n\nEvery\tO\nsingle\tO\none\tO\nwe\tO\n've\tO\ngotten\tO\nwe\tO\n've\tO\nhad\tO\nproblems\tO\nwith\tO\n.\tO\n\nit\tO\nis\tO\nthe\tO\nworst\tO\ncomputer\tO\ndell\tO\never\tO\nmade\tO\n.\tO\n\n(\tO\nIf\tO\nyou\tO\never\tO\nsee\tO\nthe\tO\nspinning\tB-aspectTerm\nbeachball\tI-aspectTerm\ncome\tO\nup\tO\nwhen\tO\nyou\tO\nthink\tO\nit\tO\nshould\tO\nn't\tO\n,\tO\ncheck\tO\nthe\tO\n\"\tO\nActivity\tO\nMonitor\tO\n\"\tO\napp\tO\nto\tO\nsee\tO\nif\tO\nthe\tO\ndisk\tB-aspectTerm\nthroughput\tI-aspectTerm\nhas\tO\ntemporarily\tO\ndropped\tO\nto\tO\nzero\tO\n.\tO\n\nI\tO\nhave\tO\nfound\tO\nalso\tO\n,\tO\nit\tO\nis\tO\nvery\tO\neasy\tO\nto\tO\nbe\tO\nable\tO\nto\tO\naccess\tO\nwireless\tB-aspectTerm\ninternet\tI-aspectTerm\naccess\tI-aspectTerm\n;\tO\n\nAbout\tO\n1/2\tO\nof\tO\nthe\tO\nsites\tO\nI\tO\nneed\tO\nto\tO\nvisit\tO\nbecause\tO\nof\tO\nmy\tO\nwork\tO\ncontain\tO\nsome\tO\ntype\tO\nof\tO\nFlash\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\ngreat\tO\nvalue\tB-aspectTerm\nfor\tO\nthe\tO\nmoney\tO\n.\tO\n\nIt\tO\nwas\tO\na\tO\ngreat\tO\nlaptop\tO\n,\tO\nran\tB-aspectTerm\ngreat\tO\nand\tO\nwas\tO\nreally\tO\nfast\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nhas\tO\nnever\tO\nworked\tO\nwell\tO\n.\tO\n\nreturn\tO\nit\tO\n.\tO\n\nI\tO\ncan\tO\nguarantee\tO\nthis\tO\nwill\tO\nbe\tO\nthe\tO\nlast\tO\nDell\tO\nI\tO\nwill\tO\never\tO\npurchase\tO\n!\tO\n\nThey\tO\nsaid\tO\nit\tO\nwas\tO\na\tO\ncomputer\tO\nerror\tO\non\tO\nthis\tO\ntype\tO\nof\tO\ncomputer\tO\n.\tO\n\nI\tO\nwill\tO\nnever\tO\nbuy\tO\nanother\tO\ncomputer\tO\nfrom\tO\nDell\tO\never\tO\nagain\tO\ndo\tO\nto\tO\nhow\tO\nawful\tO\nit\tO\nworked\tO\nand\tO\nhow\tO\nI\tO\nwas\tO\ntreated\tO\nby\tO\nthe\tO\ncompany\tB-aspectTerm\n.\tO\n\nMy\tO\nreview\tO\nmainly\tO\ntalks\tO\nabout\tO\nthe\tO\ndifference\tO\nI\tO\nhave\tO\nfelt\tO\nbetween\tO\nan\tO\nearly\tO\n2011\tO\nand\tO\nlate\tO\n2011\tO\nmac\tO\nbook\tO\npro\tO\n.\tO\n\nThat\tO\nwas\tO\na\tO\nbig\tO\nmistake\tO\n.\tO\n\nThe\tO\nonly\tO\nproblem\tO\nis\tO\na\tO\nlack\tO\nof\tO\nscreen\tB-aspectTerm\nresolutions\tI-aspectTerm\n!\tO\n\nSmall\tO\nenough\tO\nto\tO\nuse\tO\non\tO\na\tO\nlong\tO\nflight\tO\n,\tO\nLight\tO\nenough\tO\nto\tO\ncarry\tB-aspectTerm\nthrough\tO\nairports\tO\nand\tO\npowerful\tO\nenough\tO\nto\tO\nreplace\tO\nmy\tO\ndesktop\tO\nwhile\tO\non\tO\nlong\tO\nbusiness\tO\ntrips\tO\n.\tO\n\nTyping\tO\non\tO\nthe\tO\nkeyboard\tB-aspectTerm\nbecomes\tO\nuncomfortable\tO\nafter\tO\nextended\tO\nuse\tO\ndue\tO\nto\tO\nthe\tO\nsharp\tO\nedges\tB-aspectTerm\nthat\tO\nyour\tO\nwrists\tO\nrest\tO\non\tO\n.\tO\n\nIf\tO\nyou\tO\nare\tO\nlooking\tO\nfor\tO\na\tO\nnetbook\tO\npc\tO\nDO\tO\nNOT\tO\nBUY\tO\nFROM\tO\nASUS\tO\n!\tO\n!\tO\n!\tO\n\nIt\tO\nhas\tO\nmany\tO\ngreat\tO\nprograms\tB-aspectTerm\n,\tO\nsuch\tO\nas\tO\nILife\tB-aspectTerm\n,\tO\niPhotos\tB-aspectTerm\nand\tO\nothers\tO\n.\tO\n\nOther\tO\nThoughts\tO\n:\tO\nReceived\tO\nreplacement\tO\n16\tO\nDays\tO\nlater\tO\n.\tO\n\nIf\tO\nthe\tO\nnumber\tO\nof\tO\npatrons\tO\nin\tO\nthe\tO\nApple\tO\nstore\tO\nare\tO\nany\tO\nindication\tO\n,\tO\nHP\tO\nand\tO\nother\tO\nPC\tO\nmanufacturers\tO\nneed\tO\nto\tO\ntake\tO\nnote\tO\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\nwent\tO\non\tO\nme\tO\n,\tO\nthe\tO\nfan\tB-aspectTerm\nwent\tO\nand\tO\nthe\tO\nmotherboard\tB-aspectTerm\nwent\tO\n.\tO\n\nI\tO\nbought\tO\nmy\tO\nfirst\tO\nMacBook\tO\nafter\tO\nseeing\tO\nthe\tO\nproduct\tO\ndemonstrated\tO\n.\tO\n\nIt\tO\nis\tO\nvery\tO\nwell\tO\nbuilt\tB-aspectTerm\n.\tO\n\nMight\tO\nnot\tO\nmake\tO\nthe\tO\navid\tO\ngamer\tO\nhappy\tO\nbut\tO\nI\tO\ndo\tO\nn't\tO\nreally\tO\nthink\tO\nthat\tO\nis\tO\nwhat\tO\nthis\tO\ncomputer\tO\nis\tO\ndesigned\tO\nfor\tO\n.\tO\n\nI\tO\nhighly\tO\nrecommend\tO\nthis\tO\nlaptop\tO\nto\tO\nanybody\tO\nthat\tO\nwants\tO\ngreat\tO\nperformance\tB-aspectTerm\nfrom\tO\na\tO\nlaptop\tO\nand\tO\nwould\tO\nlike\tO\nto\tO\nrelax\tO\nand\tO\nnot\tO\nbecome\tO\nenraged\tO\ncursing\tO\nthe\tO\ngods\tO\nabout\tO\nto\tO\nthrow\tO\nyour\tO\nlaptop\tO\nout\tO\nthe\tO\ndoor\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nresolution\tI-aspectTerm\nwas\tO\nexactly\tO\nwhat\tO\nI\tO\nwas\tO\nlooking\tO\nfor\tO\n.\tO\n\nEven\tO\nthough\tO\nit\tO\nis\tO\nrunning\tO\nSnow\tB-aspectTerm\nLeopard\tI-aspectTerm\n,\tO\n2.4\tO\nGHz\tO\nC2D\tO\nis\tO\na\tO\nbit\tO\nof\tO\nan\tO\nantiquated\tO\nCPU\tB-aspectTerm\nand\tO\nthus\tO\nthe\tO\noccasional\tO\nspinning\tB-aspectTerm\nwheel\tI-aspectTerm\nwould\tO\nappear\tO\nwhen\tO\nrunning\tO\nOffice\tB-aspectTerm\nMac\tI-aspectTerm\napplications\tI-aspectTerm\nsuch\tO\nas\tO\nWord\tB-aspectTerm\nor\tO\nExcel\tB-aspectTerm\n.\tO\n\nseriously\tO\nwhy\tO\nhave\tO\nn't\tO\nthey\tO\njust\tO\nreplaced\tO\nit\tO\nby\tO\nnow\tO\n.\tO\n\nThere\tO\nis\tO\nno\tO\nnumber\tO\npad\tB-aspectTerm\nto\tO\nthe\tO\nright\tO\nof\tO\nthe\tO\nkeyboard\tB-aspectTerm\nwhich\tO\nis\tO\na\tO\nbummer\tO\n.\tO\n\nAfter\tO\n20\tO\n-\tO\n30\tO\nmin\tO\nthe\tO\nscreen\tB-aspectTerm\nof\tO\nthe\tO\nnotebook\tO\nswitched\tO\noff\tO\n.\tO\n\nIf\tO\nupgrade\tO\nis\tO\npossible\tO\nto\tO\nthe\tO\nfull\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\n,\tO\nthen\tO\nI\tO\nwill\tO\ntruly\tO\nbe\tO\na\tO\nvery\tO\nhappy\tO\ngeek\tO\n.\tO\n\nI\tO\nhave\tO\nused\tO\nboth\tO\nPCs\tO\nand\tO\nMacs\tO\nand\tO\nI\tO\nhave\tO\nto\tO\nsay\tO\nthat\tO\nI\tO\nreally\tO\nreally\tO\nlove\tO\nmy\tO\nMac\tO\nBook\tO\nPro\tO\n.\tO\n\nI\tO\nwas\tO\noriginally\tO\nconcerned\tO\nthat\tO\nI\tO\ncould\tO\nn't\tO\nview\tO\nwork\tO\nI\tO\nhad\tO\ndone\tO\nin\tO\ncollege\tO\non\tO\nmy\tO\nMac\tO\nbecause\tO\nof\tO\nthe\tO\nPC\tO\nformatting\tO\n,\tO\nbut\tO\nI\tO\nwas\tO\neven\tO\nmore\tO\nthrilled\tO\nto\tO\nlearn\tO\nof\tO\nprograms\tB-aspectTerm\nlike\tO\niLife\tB-aspectTerm\nand\tO\niWork\tB-aspectTerm\nthat\tO\nallow\tO\nyou\tO\nto\tO\nconvert\tO\nyour\tO\nPC\tO\ndocuments\tO\ninto\tO\nreadable\tO\nfiles\tO\non\tO\nMacs\tO\n.\tO\n\nIt\tO\nis\tO\na\tO\nbig\tO\nbig\tO\n,\tO\nbut\tO\nsince\tO\nit\tO\nhas\tO\na\tO\n18.4\tB-aspectTerm\n\"\tI-aspectTerm\nscreen\tI-aspectTerm\nwhat\tO\nwould\tO\nyou\tO\nexpect\tO\n!\tO\n\nI\tO\nhave\tO\nnever\tO\nhad\tO\nan\tO\nexperience\tO\nlike\tO\nthis\tO\n.\tO\n\nWe\tO\nhave\tO\nn't\tO\nhad\tO\nany\tO\nproblems\tO\nwith\tO\nit\tO\nat\tO\nall\tO\n.\tO\n\nreturned\tO\nit\tO\nto\tO\nwalmart\tO\n.\tO\n\n10\tO\nhours\tO\nof\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nreally\tO\nsomething\tO\nelse\tO\n....\tO\n\nI\tO\nlove\tO\neverything\tO\nabout\tO\nit\tO\n.\tO\n\nIt\tO\n's\tO\nslow\tO\nand\tO\none\tO\nday\tO\ni\tO\nhope\tO\nto\tO\nhave\tO\nthe\tO\nmoney\tO\nto\tO\nget\tO\nrid\tO\nof\tO\nit\tO\nand\tO\nbuy\tO\nsomething\tO\nelse\tO\n.\tO\n\nIt\tO\nmeets\tO\nall\tO\nmy\tO\nneeds\tO\nfor\tO\nwork\tO\nand\tO\npleasure\tO\nwhile\tO\ntraveling\tO\n.\tO\n\nRuns\tB-aspectTerm\nfast\tO\nand\tO\nthe\tO\nregular\tB-aspectTerm\nlayout\tI-aspectTerm\nkeyboard\tI-aspectTerm\nis\tO\nso\tO\nmuch\tO\nbetter\tO\n.\tO\n\nAll\tO\nwas\tO\nwell\tO\n.\tO\n\nAll\tO\nthe\tO\nprograms\tB-aspectTerm\nare\tO\neasy\tO\nand\tO\nstraight\tO\nforward\tO\non\tO\nmy\tO\nMacBook\tO\nPro\tO\n,\tO\nit\tO\nis\tO\nclean\tO\nand\tO\norganized\tO\n,\tO\nwhich\tO\nI\tO\nalways\tO\nstrive\tO\nto\tO\nbe\tO\nmyself\tO\n.\tO\n\nHe\tO\nsaid\tO\nquite\tO\na\tO\nnumber\tO\nof\tO\npeople\tO\nhad\tO\nencountered\tO\nthis\tO\nproblem\tO\nand\tO\nsaid\tO\nit\tO\nis\tO\na\tO\ncommon\tO\nissue\tO\n.\tO\n\nNot\tO\nworth\tO\nit\tO\none\tO\nbit\tO\n.\tO\n\nI\tO\njust\tO\nca\tO\nn't\tO\nfathom\tO\nthat\tO\nthe\tO\ncelebrated\tO\nDell\tO\nwould\tO\nlast\tO\na\tO\nweek\tO\nin\tO\nenvironment\tO\nof\tO\nfree\tO\ncompetition\tO\nwith\tO\nnormal\tO\nproducts\tO\n-\tO\nit\tO\nonly\tO\nsurvives\tO\nb\tO\n/\tO\nc\tO\nits\tO\nsubstandard\tO\nlaptops\tO\nare\tO\nforced\tO\nonto\tO\ncaptive\tO\nstudents\tO\nand\tO\nemployees\tO\nthrough\tO\nquestion\tO\n-\tO\nraising\tO\nprograms\tO\n.\tO\n\nMuch\tO\nof\tO\nwhich\tO\nHP\tO\nended\tO\nup\tO\npaying\tO\nfor\tO\n.\tO\n\nI\tO\nreinstalled\tO\nwindows\tB-aspectTerm\nthrough\tO\nthe\tO\nrecovery\tB-aspectTerm\ndiscs\tI-aspectTerm\nand\tO\neverything\tO\nseemed\tO\ngood\tO\nagain\tO\n.\tO\n\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nStarter\tI-aspectTerm\nis\tO\nterrific\tO\n(\tO\nno\tO\nyou\tO\nca\tO\nn't\tO\nchange\tO\nthe\tO\nbackground\tO\n)\tO\nbut\tO\nI\tO\ndo\tO\nn't\tO\nneed\tO\nto\tO\n,\tO\nI\tO\nuse\tO\nit\tO\njust\tO\nfor\tO\nschool\tO\nwork\tO\n.\tO\n\nSupport\tB-aspectTerm\nhas\tO\nbeen\tO\nlackluster\tO\nand\tO\nnow\tO\nI\tO\njust\tO\nwant\tO\na\tO\nrefund\tO\n.\tO\n\nFirst\tO\nof\tO\nall\tO\n,\tO\nthey\tO\nhad\tO\nno\tO\nrecord\tO\nof\tO\nme\tO\nhaving\tO\nthe\tO\n3\tB-aspectTerm\nyear\tI-aspectTerm\nwarranty\tI-aspectTerm\nI\tO\n'd\tO\npaid\tO\nalmost\tO\n$\tO\n400\tO\nfor\tO\n,\tO\nand\tO\nI\tO\nhad\tO\nto\tO\ncall\tO\nin\tO\n,\tO\nspend\tO\nhours\tO\non\tO\ntheir\tO\nonline\tB-aspectTerm\nchat\tI-aspectTerm\nservice\tI-aspectTerm\n,\tO\nand\tO\nfax\tO\nin\tO\nmultiple\tO\ndocuments\tO\n.\tO\n\nI\tO\nhate\tO\nto\tO\nsay\tO\nthis\tO\n,\tO\nbut\tO\nif\tO\nI\tO\ncould\tO\ntake\tO\nthis\tO\nback\tO\nto\tO\nthe\tO\nshop\tO\nand\tO\nget\tO\nmy\tO\nmoney\tO\nback\tO\n,\tO\nthen\tO\nI\tO\nwould\tO\n.\tO\n\nIt\tO\nmakes\tO\ndoing\tO\nschoolwork\tO\nat\tO\nnight\tO\nso\tO\nmuch\tO\neasier\tO\n.\tO\n\nBeing\tO\nonly\tO\n2\tO\nmonths\tO\nold\tO\n,\tO\nI\tO\nam\tO\nnot\tO\na\tO\nhappy\tO\ncamper\tO\n!\tO\n\n\"\tO\n>\tO\niPhoto\tO\nis\tO\nprobably\tO\nthe\tO\nbest\tO\nprogram\tO\nI\tO\nhave\tO\never\tO\nworked\tO\nwith\tO\n:\tO\neasy\tO\nand\tO\nconvenient\tO\n.\tO\n\nI\tO\nlove\tO\nto\tO\nwrite\tO\nand\tO\nplay\tO\nwith\tO\ngraphics\tO\nand\tO\nhtml\tO\nprogramming\tO\nand\tO\nmy\tO\nnew\tO\nToshiba\tO\nworks\tB-aspectTerm\ngreat\tO\non\tO\nboth\tO\n!\tO\n\nTHis\tO\ncomputer\tO\nmay\tO\nbe\tO\nsmall\tO\nbut\tO\nit\tO\nis\tO\none\tO\nheck\tO\nof\tO\na\tO\npower\tO\nhorse\tO\n.\tO\n\nThey\tO\nwould\tO\nrepair\tO\none\tO\nthing\tO\n,\tO\nsend\tO\nit\tO\nback\tO\nand\tO\nit\tO\nwould\tO\nstill\tO\nhave\tO\nthe\tO\nsame\tO\nproblem\tO\n.\tO\n\nSuch\tO\nas\tO\nPAGES\tO\n,\tO\nNUMBERS\tO\n,\tO\nand\tO\nso\tO\non\tO\n.\tO\n\nMy\tO\nlaptop\tO\nnow\tO\nhas\tO\nno\tO\nbattery\tB-aspectTerm\n.\tO\n\nBeta\tO\nhad\tO\nbetter\tO\nquality\tB-aspectTerm\n,\tO\nbut\tO\nVHS\tB-aspectTerm\nbecame\tO\nthe\tO\nindustry\tO\nstandard\tO\n.\tO\n\nIt\tO\nmade\tO\nthe\tO\ncomputer\tO\nmuch\tO\neasier\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nnavigate\tB-aspectTerm\n.\tO\n\n:\tO\n-)If\tO\nyou\tO\nbuy\tO\nthis\tO\n-\tO\ndo\tO\nn't\tO\ngo\tO\ninto\tO\nit\tO\nexpecting\tO\n7\tO\nhrs\tO\nof\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n,\tO\nand\tO\nyou\tO\n'll\tO\nbe\tO\nperfectly\tO\nsatisfied\tO\n.\tO\n\nNeeds\tO\nlonger\tO\nlasting\tO\nbattery\tB-aspectTerm\n,\tO\nMore\tO\nthan\tO\n1\tO\nto\tO\n2\tO\nHrs\tO\n.\tO\n\nin\tO\nMay\tO\nI\tO\nstarted\tO\nhaving\tO\nproblems\tO\nwith\tO\nthe\tO\nUSB\tB-aspectTerm\nports\tI-aspectTerm\nnot\tO\nworking\tO\n.\tO\n\n10\tO\nplus\tO\nhours\tO\nof\tO\nbattery\tB-aspectTerm\n...\tO\n\nIf\tO\nonly\tO\nBill\tO\nGates\tO\nwould\tO\nread\tO\nsome\tO\nof\tO\nwhat\tO\nis\tO\nsaid\tO\nhere\tO\nMS\tO\nwould\tO\ndo\tO\na\tO\nbetter\tO\njob\tO\n.\tO\n\nThe\tO\ndesign\tB-aspectTerm\nis\tO\nawesome\tO\n,\tO\nquality\tB-aspectTerm\nis\tO\nunprecedented\tO\n.\tO\n\nI\tO\n'm\tO\ngoing\tO\nto\tO\ntry\tO\nand\tO\nkeep\tO\nmy\tO\nold\tO\nG4\tO\non\tO\nthe\tO\nroad\tO\nfor\tO\nas\tO\nlong\tO\nas\tO\npossible\tO\n.\tO\n\nThe\tO\nMac\tB-aspectTerm\nversion\tI-aspectTerm\nof\tI-aspectTerm\nMicrosoft\tI-aspectTerm\nOffice\tI-aspectTerm\nis\tO\ncheaper\tO\nthan\tO\nbuying\tO\nthe\tO\nactual\tO\nand\tO\nworks\tO\njust\tO\nas\tO\nwell\tO\n.\tO\n\nThe\tO\nMac\tO\ntakes\tO\nabout\tO\nthe\tO\nsame\tO\namount\tO\nof\tO\nstarting\tB-aspectTerm\n-\tI-aspectTerm\nup\tI-aspectTerm\ntime\tI-aspectTerm\nas\tO\nthe\tO\naverage\tO\nPC\tO\n,\tO\nbut\tO\nkeeps\tO\nitself\tO\ncleaned\tO\nup\tO\nand\tO\nready\tO\nto\tO\nuse\tO\n.\tO\n\nIts\tO\nhard\tO\nto\tO\nencounter\tO\na\tO\nproblem\tO\non\tO\na\tO\nmac\tO\nthat\tO\nwould\tO\nrequire\tO\nsuch\tO\nabrupt\tO\naction\tO\n.\tO\n\nThe\tO\nToshiba\tO\nNet\tO\nbook\tO\noperates\tB-aspectTerm\nvery\tO\nwell\tO\n.\tO\n\nI\tO\nloved\tO\nit\tO\n.\tO\n\nthe\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\nis\tO\nfine\tO\n-\tO\nagain\tO\n,\tO\nit\tO\n's\tO\na\tO\nreal\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\n.\tO\n\nThe\tO\npictures\tB-aspectTerm\nare\tO\nclear\tO\nas\tO\ncan\tO\nbe\tO\n.\tO\n\nIt\tO\nis\tO\nalso\tO\nvery\tO\nlightweight\tO\n,\tO\nmaking\tO\ntransporting\tB-aspectTerm\nthis\tO\ncomputer\tO\nvery\tO\neasy\tO\n.\tO\n\nIf\tO\nanything\tO\n,\tO\nI\tO\nwould\tO\nonly\tO\nsuggest\tO\nusing\tO\none\tO\nof\tO\nthese\tO\nlaptops\tO\nif\tO\nonly\tO\nyou\tO\nhave\tO\nto\tO\n.\tO\n\nI\tO\nsit\tO\ndown\tO\nand\tO\nuse\tO\nmy\tO\nhusband\tO\n's\tO\nwork\tO\nPC\tO\nand\tO\nI\tO\ndo\tO\nn't\tO\nlike\tO\nit\tO\none\tO\nbit\tO\n.\tO\n\nIt\tO\n's\tO\nwonderful\tO\nfor\tO\ncomputer\tO\ngaming\tB-aspectTerm\n.\tO\n\nYou\tO\nhave\tO\nto\tO\ntoss\tO\nout\tO\nthe\tO\nwifi\tB-aspectTerm\ncard\tI-aspectTerm\nand\tO\nreplace\tO\nit\tO\njust\tO\nto\tO\nhave\tO\nany\tO\nsort\tO\nof\tO\nnetwork\tB-aspectTerm\ncapability\tI-aspectTerm\n.\tO\n\nAND\tO\nthe\tO\nbest\tO\npart\tO\nis\tO\nthat\tO\nit\tO\neven\tO\ncomes\tO\nwith\tO\na\tO\nfree\tO\nprinter\tB-aspectTerm\n(\tO\nwhen\tO\nthey\tO\nhave\tO\na\tO\ncertain\tO\npromotion\tO\n/\tO\noffer\tO\ngoing\tO\n,\tO\nof\tO\ncourse\tO\n)\tO\n!\tO\n\nthe\tO\nplace\tO\nwe\tO\nbought\tO\nit\tO\nfrom\tO\nsaid\tO\nthat\tO\nafter\tO\nthey\tO\nsend\tO\nit\tO\nout\tO\nto\tO\ngateway\tO\n4\tO\ntimes\tO\nthey\tO\nwould\tO\ngive\tO\nus\tO\na\tO\nnew\tO\none\tO\n.\tO\n\nit\tO\nis\tO\nvery\tO\neasy\tO\nfor\tO\nanyone\tO\nto\tO\nuse\tB-aspectTerm\nan\tO\napple\tO\nand\tO\nspecially\tO\nthe\tO\nmcbook\tO\npro\tO\nnotebook\tO\n.\tO\n\nI\tO\nlike\tO\nit\tO\nbetter\tO\nthan\tO\nmy\tO\nbig\tO\nDell\tO\nLaptop\tO\n.\tO\n\nThe\tO\nflaws\tO\nare\tO\n,\tO\nthis\tO\ncomputer\tO\nis\tO\nnot\tO\nfor\tO\ncomputer\tO\ngamers\tO\nbecause\tO\nof\tO\nthe\tO\nOS\tB-aspectTerm\nX.\tI-aspectTerm\n\nI\tO\ntried\tO\ngiving\tO\nit\tO\n0\tO\nstars\tO\nbut\tO\nI\tO\nhad\tO\nto\tO\nchoose\tO\nat\tO\nleast\tO\none\tO\n,\tO\nbut\tO\nIMO\tO\nNO\tO\nSTARS\tO\n\nThey\tO\nreally\tO\ndo\tO\nhave\tO\nthe\tO\nworlds\tO\nvery\tO\nworst\tO\nrepair\tB-aspectTerm\nservice\tI-aspectTerm\n.\tO\n\nThey\tO\nneed\tO\nto\tO\nstop\tO\noutsoucing\tO\nand\tO\nsend\tO\nsome\tO\ncomplaint\tO\ncalls\tO\nto\tO\nUS\tO\nbased\tO\ncustomer\tB-aspectTerm\nservice\tI-aspectTerm\nagents\tI-aspectTerm\nfor\tO\nthose\tO\nwho\tO\nlive\tO\nin\tO\nthe\tO\nUnited\tO\nstates\tO\n.\tO\n\nI\tO\nwas\tO\nalso\tO\nable\tO\nto\tO\ninstall\tO\nand\tO\nuse\tO\nmy\tO\nPhotoshop\tO\nand\tB-aspectTerm\nAfterEffects\tO\nprograms\tB-aspectTerm\neasily\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nperfect\tO\nfor\tO\neverything\tO\nand\tO\nruns\tB-aspectTerm\nfaster\tO\nthan\tO\nan\tO\naverage\tO\npc\tO\n!\tO\n\nfor\tO\nbeing\tO\nso\tO\nsmall\tO\nit\tO\nis\tO\namazing\tO\nthat\tO\nit\tO\nis\tO\nas\tO\nfast\tO\nas\tO\nit\tO\nis\tO\n.\tO\n\nHeck\tO\n,\tO\nI\tO\nlike\tO\nall\tO\nMac\tO\ncomputers\tO\n,\tO\nbut\tO\nthey\tO\n're\tO\nall\tO\nWAY\tO\ntoo\tO\npricey\tO\nfor\tO\nthe\tO\nkind\tO\nof\tO\neconomy\tO\nthe\tO\nU.S.\tO\nis\tO\ngoing\tO\nthrough\tO\n.\tO\n\nThen\tO\nafter\tO\npaying\tO\nfor\tO\nit\tO\nto\tO\nbe\tO\nexamined\tO\nI\tO\nwas\tO\ntold\tO\nit\tO\nwas\tO\nsame\tO\nproblem\tO\ncited\tO\non\tO\nwebsite\tO\nbut\tO\nI\tO\n'd\tO\nhave\tO\nto\tO\npay\tO\nanyways\tO\nsince\tO\nit\tO\nwas\tO\npast\tO\nwarrenty\tO\n.\tB-aspectTerm\n\nThey\tO\nclaim\tO\nthat\tO\nI\tO\nshould\tO\nbe\tO\nhappy\tO\nbecause\tO\nI\tO\nam\tO\ngetting\tO\na\tO\nnew\tO\nlaptop\tO\nto\tO\nreplace\tO\nmy\tO\ntwo\tO\n-\tO\nmonth\tO\nold\tO\nlaptop\tO\n.\tO\n\nI\tO\n'm\tO\nalready\tO\nhooked\tO\non\tO\nthe\tO\nsleek\tO\nlook\tB-aspectTerm\nand\tO\ndependability\tB-aspectTerm\nthat\tO\nthis\tO\nlaptop\tO\nhas\tO\nshown\tO\n.\tO\n\nThe\tO\nmachine\tO\nitself\tO\nis\tO\nalright\tO\n.\tO\n\nIt\tO\nseems\tO\nto\tO\nhave\tO\nsome\tO\nopions\tO\nthat\tO\nare\tO\nintalled\tO\nbut\tO\ndo\tO\nnot\tO\nwork\tO\nlike\tO\nI\tO\nthought\tO\nthey\tO\nwould\tO\n.\tO\n\nAnd\tO\nhaving\tO\nto\tO\ndeal\tO\nwith\tO\nthe\tO\ncompany\tB-aspectTerm\nhas\tO\nbeen\tO\na\tO\neven\tO\nworse\tO\nnightmare\tO\n.\tO\n\nI\tO\nwill\tO\ndefinitely\tO\nbe\tO\ngetting\tO\na\tO\nnew\tO\nlaptop\tO\nif\tO\nit\tO\nhas\tO\nany\tO\nmore\tO\nissues\tO\nafter\tO\nthe\tO\nwarranty\tO\nexpires\tB-aspectTerm\nand\tO\nresearching\tO\ncarefully\tO\nwhen\tO\nI\tO\ndo\tO\nso\tO\nI\tO\ndo\tO\nn't\tO\nrun\tO\naccross\tO\na\tO\nsituation\tO\nlike\tO\nthis\tO\nagain\tO\n!\tO\n\nI\tO\nalso\tO\nexperience\tO\nthe\tO\nsame\tO\nwith\tO\nmy\tO\nMacBook\tO\nAir\tO\n.\tO\n\nIt\tO\nhas\tO\nall\tO\nthe\tO\nfeatures\tB-aspectTerm\nthat\tO\nare\tO\nnecessary\tO\nfor\tO\ncollege\tO\nand\tO\nif\tO\nnot\tO\nthey\tO\nare\tO\nable\tO\nto\tO\nbe\tO\nadded\tO\nonto\tO\nthe\tO\ncomputer\tO\n.\tO\n\nI\tO\nhave\tO\nowned\tO\nmany\tO\ndifferent\tO\nbrands\tO\nof\tO\nlaptops\tO\nin\tO\nmy\tO\nlife\tO\n.\tO\n\nI\tO\ndid\tO\nan\tO\ninternet\tO\nsearch\tO\nand\tO\nthis\tO\nis\tO\na\tO\nvery\tO\ncommon\tO\nproblem\tO\nwith\tO\nthis\tO\nlaptop\tO\n.\tO\n\nI\tO\n've\tO\nowned\tO\nthis\tO\nlabtop\tO\nfor\tO\nless\tO\nthen\tO\ntwo\tO\nmonths\tO\n,\tO\nalready\tO\nthe\tO\nmouse\tB-aspectTerm\nbutton\tI-aspectTerm\nhas\tO\nbroke\tO\n.\tO\n\nIt\tO\ndid\tO\nfairly\tO\nwell\tO\n,\tO\nother\tO\nthan\tO\nit\tO\n's\tO\npoor\tO\nperformance\tB-aspectTerm\n,\tO\noverheating\tO\nand\tO\noccational\tO\nblue\tO\nscreen\tO\n.\tO\n\nThe\tO\ntouchpad\tB-aspectTerm\nis\tO\nvery\tO\nintuitive\tO\n,\tO\nso\tO\nmuch\tO\nso\tO\nthat\tO\nI\tO\nnever\tO\nwant\tO\nto\tO\nuse\tO\nbuttons\tB-aspectTerm\nto\tO\nclick\tO\nagain\tO\n!\tO\n\ntons\tO\nof\tO\nbloatware\tO\nand\tO\njunk\tO\nprograms\tB-aspectTerm\n.\tO\n\nits\tO\nsad\tO\nbecause\tO\ntheir\tO\ncommercials\tO\nare\tO\ngreat\tO\n.\tO\n\nlots\tO\nof\tO\nextra\tO\nspace\tB-aspectTerm\nbut\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\nridiculously\tO\nsmall\tO\n.\tO\n\nLuckily\tO\n,\tO\nDell\tO\nsaid\tO\nthey\tO\nwould\tO\nreplace\tO\nmy\tO\nlaptop\tO\nwith\tO\na\tO\nnew\tO\none\tO\n,\tO\nbut\tO\ninstead\tO\nI\tO\ngot\tO\na\tO\nrefund\tO\nand\tO\nbought\tO\na\tO\nmac\tO\n.\tO\n\nI\tO\ndecided\tO\nto\tO\nget\tO\nthis\tO\npile\tO\nof\tO\ncrap\tO\non\tO\na\tO\nwhim\tO\nand\tO\ntotally\tO\nfreaking\tO\nregret\tO\nit\tO\n.\tO\n\nNever\tO\nbeen\tO\nhacked\tO\n.\tO\n\nIt\tO\n's\tO\nso\tO\nbad\tO\nthat\tO\nI\tO\n'm\tO\nthinking\tO\nI\tO\nonly\tO\ngot\tO\nhalf\tO\na\tO\nbattery\tB-aspectTerm\nor\tO\nsomething\tO\n.\tO\n\nGood\tO\nkeyboard\tB-aspectTerm\n,\tO\nlong\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n,\tO\nlargest\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\n.\tO\n\nI\tO\nthink\tO\nit\tO\nwas\tO\nseventy\tO\nnine\tO\nplus\tO\ntax\tO\n.\tO\n\nIn\tO\nsummary\tO\n,\tO\ntake\tO\nyour\tO\nmoney\tO\nelsewhere\tO\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\nis\tO\nvery\tO\nquick\tO\nand\tO\neffective\tO\nas\tO\nI\tO\nload\tB-aspectTerm\nwebpages\tB-aspectTerm\nand\tO\napplications\tB-aspectTerm\n.\tO\n\nMy\tO\nbattery\tB-aspectTerm\nwent\tO\nbad\tO\nabout\tO\na\tO\nyear\tO\nand\tO\na\tO\nhalf\tO\nafter\tO\nhaving\tO\nit\tO\nand\tO\nit\tO\ncost\tO\naround\tO\neighty\tO\nto\tO\na\tO\nhundred\tO\ndollars\tO\n!\tO\n\nI\tO\nwill\tO\nNEVER\tO\nbuy\tO\n(\tO\nRefurbished\tO\n)\tO\nagain\tO\n,\tO\nI\tO\ndo\tO\nn't\tO\ncae\tO\nhow\tO\ncheap\tO\nit\tO\nis\tO\n.\tO\n\nIt\tO\npretty\tO\nmuch\tO\ndoes\tO\neverything\tO\nwe\tO\ncould\tO\never\tO\nneed\tO\n,\tO\nand\tO\nlooks\tO\ngreat\tO\nto\tO\nboot\tB-aspectTerm\n.\tO\n\nIt\tO\nis\tO\njust\tO\nslow\tO\nslow\tO\nslow\tO\n.\tO\n\nBottom\tO\nline\tO\n,\tO\nI\tO\ndoubt\tO\nyou\tO\n'd\tO\nbe\tO\noverly\tO\ndisappointed\tO\nif\tO\nyou\tO\ninvest\tO\nin\tO\nthis\tO\nmachine\tO\n.\tO\n\nAs\tO\na\tO\nlifelong\tO\nWindows\tB-aspectTerm\nuser\tO\n,\tO\nI\tO\nwas\tO\nextremely\tO\npleased\tO\nto\tO\nmake\tO\nthe\tO\nchange\tO\nto\tO\nMac\tO\n.\tO\n\nSo\tO\n,\tO\nowing\tO\nto\tO\nthese\tO\nproblems\tO\n,\tO\nI\tO\nwent\tO\nout\tO\nand\tO\ngot\tO\nmyself\tO\nan\tO\nApple\tO\nMacBook\tO\nPro\tO\n,\tO\nwhich\tO\nI\tO\nam\tO\nusing\tO\nwith\tO\ngreat\tO\nsatisfaction\tO\nat\tO\nthis\tO\nvery\tO\nmoment\tO\n.\tO\n\nThe\tO\nMacbook\tO\nPro\tO\nis\tO\nextremely\tO\nthin\tO\nand\tO\nlight\tO\ncompared\tO\nto\tO\nthose\tO\nheavy\tO\nWindows\tO\nLaptop\tO\n.\tO\n\nSo\tO\nthis\tO\nwas\tO\ngreat\tO\nfor\tO\nme\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nmacbook\tO\nI\tO\nhave\tO\never\tO\nhad\tO\n.\tO\n\nThe\tO\nacer\tO\none\tO\ncompuer\tO\nis\tO\na\tO\ngreat\tO\ncomputer\tO\n.\tO\n\nanother\tO\nproblem\tO\n.\tO\n\nThe\tO\nMacbook\tO\nis\tO\nalso\tO\nmade\tO\nbetter\tO\n,\tO\nmy\tO\ncomputer\tO\nhas\tO\nnever\tO\ngot\tO\na\tO\nvirus\tO\n,\tO\nand\tO\nthe\tO\nlaptop\tO\nruns\tB-aspectTerm\njust\tO\nas\tO\nfast\tO\nas\tO\nthe\tO\nfirst\tO\nday\tO\nI\tO\nbought\tO\nit\tO\n.\tO\n\nSo\tO\n,\tO\nif\tO\nyou\tO\n're\tO\nthinking\tO\nof\tO\na\tO\nlaptop\tO\n,\tO\nI\tO\nwould\tO\nheartily\tO\nrecommend\tO\ntheApple\tO\n13.3\tO\nMacBook\tO\nPro\tO\nNotebook\tO\nComputer\tO\n(\tO\nZ0J80001\tO\n)\tO\nNotebook\tO\nfor\tO\nall\tO\nyour\tO\nneeds\tO\n!\tO\n\nI\tO\nwiped\tO\nnearly\tO\neverything\tO\noff\tO\nof\tO\nit\tO\n,\tO\ninstalled\tO\nOpenOffice\tB-aspectTerm\nand\tO\nFirefox\tB-aspectTerm\n,\tO\nand\tO\nI\tO\nam\tO\noperating\tO\nan\tO\nincredibly\tO\nefficient\tO\nand\tO\nuseful\tO\nmachine\tO\nfor\tO\na\tO\ngreat\tO\nprice\tB-aspectTerm\n.\tO\n\nOverall\tO\nI\tO\nfeel\tO\nthis\tO\nnetbook\tO\nwas\tO\npoor\tO\nquality\tB-aspectTerm\n,\tO\nhad\tO\npoor\tO\nperformance\tB-aspectTerm\n,\tO\nalthough\tO\nit\tO\ndid\tO\nhave\tO\ngreat\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwhen\tO\nit\tO\ndid\tO\nwork\tO\n.\tO\n\nI\tO\npicked\tO\nit\tO\nout\tO\nbecause\tO\nit\tO\nwas\tO\ninexpensive\tO\n(\tO\n$\tO\n400\tO\n)\tO\nand\tO\nI\tO\nthought\tO\nit\tO\nwould\tO\nbe\tO\na\tO\ngood\tO\n,\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nfirst\tO\nlaptop\tO\n.\tO\n\nMY\tO\nONLY\tO\nPROBLEM\tO\nIS\tO\nI\tO\nCAN\tO\nNOT\tO\nREG\tO\n.\tO\nTHE\tO\nPRODUCT\tB-aspectTerm\nKEY\tI-aspectTerm\n.\tO\n\nThe\tO\n\"\tO\nTime\tO\nremaining\tO\n\"\tO\ngoes\tO\nfrom\tO\n4\tO\nhours\tO\nplus\tO\nto\tO\nless\tO\nthan\tO\n2\tO\nhours\tO\nover\tO\nthe\tO\nspan\tO\nof\tO\nabout\tO\n10\tO\nminutes\tO\n.\tO\n\nPay\tO\nattention\tO\nto\tO\nthe\tO\nspecs\tB-aspectTerm\nif\tO\nyou\tO\nwant\tO\nthese\tO\noptions\tO\n.\tO\n\nStupidly\tO\n,\tO\nmind\tO\n-\tO\nnumbingly\tO\nslow\tO\n--\tO\nthen\tO\nI\tO\nfound\tO\nit\tO\ncan\tO\nonly\tO\nbe\tO\nloaded\tO\nwith\tO\n2\tO\nGB\tO\n*\tO\nmaximum*.\tO\n\nIt\tO\nalso\tO\ndoes\tO\nnot\tO\nhave\tO\nbluetooth\tB-aspectTerm\n.\tO\n\nSure\tO\nit\tO\nhas\tO\nthe\tO\none\tB-aspectTerm\ntouch\tI-aspectTerm\nkeys\tI-aspectTerm\nbut\tO\nthat\tO\nwas\tO\nthe\tO\nbest\tO\nfeature\tB-aspectTerm\nof\tO\nthe\tO\ncomputer\tO\n.\tO\n\nI\tO\ncan\tO\ndo\tO\npretty\tO\nmuch\tO\n75\tO\n%\tO\nof\tO\nwhat\tO\nI\tO\ndo\tO\non\tO\nmy\tO\ndesktop\tO\non\tO\nmy\tO\nkitchen\tO\ntable\tO\n.\tO\n\nBeing\tO\na\tO\nPC\tO\nuser\tO\nmy\tO\nwhole\tO\nlife\tO\n....\tO\n\ngreat\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nThe\tO\nreal\tO\nstand\tO\nout\tO\non\tO\nthis\tO\ncomputer\tO\nis\tO\nthe\tO\nfeel\tO\nof\tO\nthe\tO\nkeyboard\tB-aspectTerm\nand\tO\nit\tO\n's\tO\nspeed\tB-aspectTerm\n.\tO\n\nAt\tO\nfirst\tO\n,\tO\nthe\tO\ncomputer\tO\nseemed\tO\na\tO\ngreat\tO\ndeal\tO\n--\tO\nseemingly\tO\nhigh\tO\n-\tO\nend\tO\nspecs\tB-aspectTerm\nfor\tO\na\tO\nlow\tO\n,\tO\nlow\tO\nprice\tB-aspectTerm\n.\tO\n\nDelivery\tB-aspectTerm\nwas\tO\nearly\tO\ntoo\tO\n.\tO\n\nDuring\tO\nthat\tO\ntime\tO\n,\tO\nI\tO\nhad\tO\nto\tO\nsend\tO\nit\tO\nback\tO\n3\tO\ntimes\tO\n.\tO\n\nAlthough\tO\nI\tO\nopted\tO\nfor\tO\nthe\tO\nlowest\tO\nend\tO\nMacBook\tO\nPro\tO\n,\tO\nthis\tO\nthing\tO\nholds\tO\nits\tO\nown\tO\n.\tO\n\nLove\tO\nthe\tO\nstability\tB-aspectTerm\nof\tO\nthe\tO\nMac\tB-aspectTerm\nsoftware\tI-aspectTerm\nand\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n.\tO\n\nAnd\tO\nthat\tO\nprobably\tO\nexplains\tO\nwhy\tO\nI\tO\n've\tO\nalready\tO\nhad\tO\nmy\tO\nSATA\tB-aspectTerm\ncontroller\tI-aspectTerm\ngo\tO\nbad\tO\nwithin\tO\na\tO\nyear\tO\nof\tO\nbuying\tO\nit\tO\n.\tO\n\nI\tO\nleft\tO\nthe\tO\nplace\tO\nangrily\tO\n.\tO\n\nI\tO\nmy\tO\nwife\tO\nis\tO\nalso\tO\nnow\tO\nthe\tO\nproud\tO\nowner\tO\nof\tO\na\tO\nMacbook\tO\nas\tO\nwell\tO\n!\tO\n\nI\tO\n've\tO\nhad\tO\na\tO\nToshiba\tO\nlaptop\tO\nin\tO\nthe\tO\npast\tO\n;\tO\n\nIt\tO\n's\tO\nalso\tO\nvery\tO\ncapable\tO\nof\tO\ndoing\tO\nmoderate\tO\nvideo\tB-aspectTerm\nediting\tI-aspectTerm\n(\tO\nalthough\tO\nyou\tO\nmay\tO\nneed\tO\nthe\tO\nperformance\tB-aspectTerm\nboost\tO\nof\tO\nthe\tO\nlarger\tO\nMacBook\tO\nPros\tO\nfor\tO\nheavy\tO\nduty\tO\nmobile\tB-aspectTerm\nvideo\tI-aspectTerm\nediting\tI-aspectTerm\n)\tO\n.\tO\n\nASUS\tO\nsaid\tO\nmy\tO\nnet\tO\n-\tO\nbook\tO\nwas\tO\nworking\tO\nproperly\tO\n.\tO\n\nI\tO\nreceived\tO\nthis\tO\nlaptop\tO\nas\tO\na\tO\ngift\tO\nand\tO\nlet\tO\nme\tO\njust\tO\ntell\tO\nyou\tO\nthat\tO\nits\tO\nthe\tO\nworst\tO\n.\tO\n\nVery\tO\nannoying\tO\n.\tO\n\nMy\tO\nmain\tO\nreason\tO\nto\tO\nconvert\tO\nwas\tO\nthe\tO\nimovie\tB-aspectTerm\nprogram\tI-aspectTerm\n.\tO\n\nIt\tO\nhas\tO\na\tO\nfaster\tO\nprocessor\tB-aspectTerm\nand\tO\nmore\tO\nram\tB-aspectTerm\n.\tO\n\nIf\tO\nyou\tO\nneed\tO\nan\tO\naffordable\tO\n,\tO\nentry\tO\n-\tO\nlevel\tO\nlaptop\tO\n,\tO\nthis\tO\nwill\tO\nfit\tO\nthe\tO\nbill\tO\n.\tO\n\nLaptops\tO\nare\tO\nusually\tO\nused\tO\non\tO\nthe\tO\ngo\tO\n,\tO\nso\tO\nwhy\tO\nnot\tO\ngive\tO\nyou\tO\na\tO\nbetter\tO\nbattery\tB-aspectTerm\n?\tO\n\nI\tO\nwill\tO\nnever\tO\ncomplain\tO\nabout\tO\nthe\tO\nprice\tB-aspectTerm\nsince\tO\nI\tO\nbelieve\tO\nyou\tO\nget\tO\nwhat\tO\nyou\tO\npay\tO\nfor\tO\nand\tO\nmy\tO\nMacBook\tO\nPro\tO\nwas\tO\nworth\tO\nevery\tO\ndollar\tO\n.\tO\n\nI\tO\nwas\tO\nn't\tO\na\tO\nbig\tO\nfan\tO\nof\tO\nthe\tO\nNetbooks\tO\nbut\tO\nthis\tO\none\tO\nwas\tO\nvery\tO\nwell\tO\ndesigned\tB-aspectTerm\n.\tO\n\nIt\tO\nmay\tO\ntake\tO\na\tO\nlittle\tO\ngetting\tO\nused\tO\nto\tO\nbut\tO\nyou\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tO\nabout\tO\nviruses\tO\nor\tO\nother\tO\nheadaches\tO\n.\tO\n\nAnd\tO\nthe\tO\nwarranty\tB-aspectTerm\non\tO\nthis\tO\nmacbook\tO\npro\tO\ncan\tO\nlast\tO\nup\tO\nto\tO\n5\tO\nyears\tO\nor\tO\n1000\tO\nbattery\tO\nrecharge\tO\ncycles\tO\n.\tO\n\nI\tO\nstill\tO\nhave\tO\nthat\tO\nstupid\tO\nbluetooth\tB-aspectTerm\nmouse\tI-aspectTerm\nto\tO\n!\tO\n\nWould\tO\nlike\tO\nmore\tO\ntrendy\tO\n,\tO\nhigh\tO\ntech\tO\nfeatures\tB-aspectTerm\n.\tO\n\nKeyboard\tB-aspectTerm\nis\tO\ngreat\tO\nbut\tO\nprimary\tO\nand\tO\nsecondary\tO\ncontrol\tB-aspectTerm\nbuttons\tI-aspectTerm\ncould\tO\nbe\tO\nmore\tO\ndurable\tO\n.\tO\n\nScreen\tB-aspectTerm\nis\tO\na\tO\nbit\tO\nglossy\tO\n,\tO\nbut\tO\nthat\tO\n's\tO\nnot\tO\ntoo\tO\nbad\tO\n.\tO\n\nReceived\tO\nthe\tO\nproduct\tO\npromptly\tO\nand\tO\nwithout\tO\nany\tO\nissues\tO\n.\tO\n\nIt\tO\nis\tO\nso\tO\ngreat\tO\n,\tO\nI\tO\ncan\tO\nHardly\tO\never\tO\ntake\tO\nmy\tO\nhands\tO\noff\tO\nit\tO\n!\tO\n\nI\tO\nremind\tO\nmyself\tO\nfrom\tO\ntime\tO\nto\tO\ntime\tO\nto\tO\ntake\tO\noff\tO\nmy\tO\nwatch\tO\nwhen\tO\never\tO\nI\tO\nlook\tO\nat\tO\nthe\tO\nsmall\tO\nscratch\tO\nthat\tO\nit\tO\nhas\tO\ncaused\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nback\tO\nagain\tO\nand\tO\nwas\tO\ntold\tO\nthe\tO\nmotherboard\tB-aspectTerm\nhad\tO\nbeen\tO\nreplaced\tO\n,\tO\nso\tO\nI\tO\nwas\tO\nnow\tO\non\tO\nthe\tO\nSECOND\tO\nmotherboard\tB-aspectTerm\nwithin\tO\n3\tO\nmonths\tO\n.\tO\n\nBut\tO\nreasons\tO\nwe\tO\nchose\tO\nthis\tO\nApple\tO\ncomputer\tO\n.\tO\n\nProcessor\tB-aspectTerm\n-\tO\nWhen\tO\ncompared\tO\nto\tO\nmy\tO\n3\tO\nweek\tO\nold\tO\nEarly\tO\n2011\tO\nedition\tO\nthere\tO\nI\tO\nbarely\tO\nexperience\tO\nany\tO\ndifference\tO\nin\tO\nperformance\tB-aspectTerm\n(\tO\n2.3\tO\nGHz\tO\nv\tO\n/\tO\ns\tO\n2.4\tO\nGHz\tO\n)\tO\n.\tO\n\nThey\tO\nsay\tO\nit\tO\ncould\tO\nbe\tO\nthe\tO\nmotherboard\tB-aspectTerm\nagain\tO\n,\tO\nbut\tO\nDell\tO\n\nI\tO\nupgraded\tO\nfrom\tO\na\tO\n5\tO\nyear\tO\nold\tO\nlaptop\tO\nand\tO\nwas\tO\namazed\tO\nto\tO\nfind\tO\nout\tO\nthat\tO\nthis\tO\ncomputer\tO\nis\tO\nmuch\tO\nslower\tO\nthen\tO\nmy\tO\nold\tO\nlaptop\tO\n.\tO\n\n2nd\tO\nBest\tO\ncomputer\tO\nin\tO\nthe\tO\nworld\tO\nonly\tO\none\tO\nway\tO\nthis\tO\ncomputer\tO\nmight\tO\nbecome\tO\nthe\tO\nbest\tO\nis\tO\nthat\tO\nit\tO\nneeds\tO\nto\tO\nupgreade\tO\npatches\tO\nto\tO\nmake\tO\nless\tO\neasier\tO\nfor\tO\npeople\tO\nto\tO\nhack\tO\ninto\tO\n\nLove\tO\nthe\tO\nspeed\tB-aspectTerm\n,\tO\nespecially\tO\n!\tO\n\nIt\tO\ncould\tO\nbe\tO\na\tO\nperfect\tO\nlaptop\tO\nif\tO\nit\tO\nwould\tO\nhave\tO\nfaster\tO\nsystem\tB-aspectTerm\nmemory\tI-aspectTerm\nand\tO\nits\tO\nradeon\tB-aspectTerm\n5850\tI-aspectTerm\nwould\tO\nhave\tO\nDDR5\tB-aspectTerm\ninstead\tO\nof\tO\nDDR3\tB-aspectTerm\n.\tO\n\nNot\tO\nonly\tO\nare\tO\nthe\tO\nversions\tO\nof\tO\nthese\tO\nprograms\tB-aspectTerm\nable\tO\nto\tO\nbe\tO\nsaved\tO\n,\tO\nworked\tO\non\tO\nand\tO\nopened\tO\non\tO\nboth\tO\na\tO\nPC\tO\nand\tO\nMac\tO\n,\tO\nthe\tO\nversions\tO\nof\tO\nthese\tO\nprograms\tB-aspectTerm\non\tO\na\tO\nMac\tO\nare\tO\ngraphically\tO\nand\tO\nfunctionally\tO\nsuperior\tO\n.\tO\n\nBy\tO\nAir\tO\nsounds\tO\nmore\tO\nlike\tO\nby\tO\ntruck\tO\nto\tO\nMe\tO\n.\tO\n\nSo\tO\nfar\tO\nit\tO\nhas\tO\nbeen\tO\nfive\tO\nmonths\tO\nsince\tO\nthe\tO\nlast\tO\nproblem\tO\nwas\tO\nfixed\tO\nand\tO\nI\tO\nam\tO\nPRAYING\tO\nit\tO\nhas\tO\nfinally\tO\nstopped\tO\n.\tO\n\nIt\tO\n's\tO\noutstanding\tO\ntoo\tO\n.\tO\n\nThe\tO\nspeed\tB-aspectTerm\ngives\tO\nyou\tO\nthe\tO\npower\tO\nto\tO\nwork\tO\non\tO\nthese\tO\nprojects\tO\nseamlessly\tO\n,\tO\nand\tO\nmultiple\tO\nat\tO\na\tO\ntime\tO\nif\tO\nyou\tO\nsowish\tO\n.\tO\n\nAwesome\tO\nlaptop\tO\nand\tO\nthe\tO\nperfect\tO\nsize\tB-aspectTerm\nto\tO\ncarry\tO\naround\tO\nin\tO\ncollege\tO\n.\tO\n\nSo\tO\nI\tO\n'm\tO\ndisappointed\tO\nin\tO\nthat\tO\nbecause\tO\ncommunicating\tO\nwith\tO\nmy\tO\nrelatives\tO\nout\tO\nof\tO\nthe\tO\narea\tO\nis\tO\na\tO\npriority\tO\n.\tO\n\nA\tO\nMONTH\tO\nLATER\tO\n,\tO\nwe\tO\nreinstall\tO\nthe\tO\nOS\tO\n(\tB-aspectTerm\nVista\tI-aspectTerm\n)\tI-aspectTerm\n.\tI-aspectTerm\n\nSome\tO\nproblems\tO\ncan\tO\nbe\tO\nfixed\tO\nif\tO\nyou\tO\npurchase\tO\nnew\tO\nsoftware\tB-aspectTerm\n,\tO\nbut\tO\nthere\tO\nis\tO\nno\tO\nguarentee\tO\n.\tO\n\nMy\tO\nreal\tO\nproblem\tO\nwith\tO\nit\tO\n?\tO\nThe\tO\nstatement\tO\nof\tO\n7\tO\nhour\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nnot\tO\njust\tO\nmere\tO\nexaggeration\tO\n--\tO\nit\tO\n's\tO\na\tO\nlie\tO\n.\tO\n\njust\tO\nchill\tO\nand\tO\nenjoy\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nalso\tO\nrelatively\tO\ngood\tO\n.\tO\n\nIt\tO\nis\tO\nher\tO\nfirst\tO\nlaptop\tO\nand\tO\nshe\tO\nis\tO\nthrilled\tO\n.\tO\n\nI\tO\nshould\tO\nhave\tO\nsent\tO\nit\tO\nback\tO\nto\tO\nthem\tO\nthen\tO\n.\tO\n\nI\tO\ndefinitely\tO\nsuggest\tO\ngetting\tO\nan\tO\nextended\tO\nwarranty\tB-aspectTerm\n,\tI-aspectTerm\nyou\tO\nwill\tO\nprobably\tO\nneed\tO\nit\tO\n!\tO\n\nIf\tO\nthis\tO\nwould\tO\nbe\tO\nyour\tO\nfirst\tO\nMac\tO\npurchase\tO\nthen\tO\nI\tO\nwould\tO\nhighly\tO\nsuggest\tO\nthat\tO\nyou\tO\ntake\tO\nadvantage\tO\nof\tO\nthe\tO\nclass\tO\nthat\tO\nthey\tO\noffer\tO\nto\tO\nlearn\tO\nabout\tO\nthe\tO\ndifferences\tO\nbetween\tO\nMac\tO\nand\tO\nPC\tO\n's\tO\n.\tO\n\nThis\tO\nlaptop\tO\nleaves\tO\nalot\tO\nto\tO\nbe\tO\ndesired\tO\n,\tO\nI\tO\nhave\tO\nhad\tO\nit\tO\nonly\tO\n5\tO\nmonths\tO\nand\tO\nhave\tO\nhad\tO\nto\tO\nsend\tO\nit\tO\naway\tO\nto\tO\nbe\tO\nrepaired\tO\ntwice\tO\n...\tO\n\nI\tO\nhave\tO\nfound\tO\nit\tO\nvery\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nvery\tO\nimformative\tO\n,\tO\nwonder\tO\nalerts\tO\nand\tO\ntutorials\tO\nmaking\tO\nit\tO\nvery\tO\neasy\tO\nfor\tO\nsomeone\tO\nlike\tO\nme\tO\nwho\tO\nis\tO\nnot\tO\nexactly\tO\ntechnologically\tO\nadvanced\tO\nto\tO\nlearn\tO\nto\tO\nuse\tO\nthe\tO\nvarious\tO\nfeatures\tB-aspectTerm\nand\tO\nprograms\tB-aspectTerm\n.\tO\n\nI\tO\ndo\tO\nn't\tO\nhave\tO\nstupid\tO\npop\tB-aspectTerm\nup\tI-aspectTerm\nwindows\tI-aspectTerm\n(\tO\neven\tO\nwhen\tO\nI\tO\nhave\tO\npop\tB-aspectTerm\nups\tI-aspectTerm\nblocked\tO\n)\tO\n,\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nwait\tO\n5\tO\nminutes\tO\nfor\tO\na\tO\nwebpage\tO\nto\tO\ndownload\tO\n,\tO\nand\tO\nbest\tO\nof\tO\nall\tO\nI\tO\ncan\tO\nrun\tO\nall\tO\nthe\tO\nweb\tB-aspectTerm\nprogramming\tI-aspectTerm\nsoftware\tI-aspectTerm\nI\tO\nneed\tO\nto\tO\nuse\tO\nall\tO\nat\tO\nonce\tO\nwithout\tO\nslowing\tO\nme\tO\ndown\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\nso\tO\nthat\tO\nthe\tO\nentire\tO\nfamily\tO\nhad\tO\na\tO\ncomputer\tO\nin\tO\nthe\tO\nliving\tO\nroom\tO\n;\tO\n\nDo\tO\nn't\tO\nwaste\tO\nyour\tO\nmoney\tO\nor\tO\ntime\tO\n.\tO\n\nIt\tO\nhas\tO\nspent\tO\nmore\tO\ntime\tO\nin\tO\nrepair\tO\nshops\tO\nthan\tO\ni\tO\ncan\tO\npossibly\tO\nrecount\tO\nhere\tO\n.\tO\n\nMemory\tB-aspectTerm\nis\tO\nupgradable\tO\n.\tO\n\nWeb\tB-aspectTerm\naccess\tI-aspectTerm\nthrough\tO\nthe\tO\n3\tB-aspectTerm\nG\tI-aspectTerm\nnetwork\tI-aspectTerm\nis\tO\nso\tO\nslow\tO\n,\tO\nit\tO\n's\tO\nvery\tO\nfrustrating\tO\nand\tO\nVERY\tO\nDISAPPOINTING\tO\n.\tO\n\nWell\tO\n,\tO\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\na\tO\nmonth\tO\nor\tO\ntwo\tO\nago\tO\n.\tO\n\nMy\tO\nMacBook\tO\nPro\tO\nhas\tO\nbeen\tO\na\tO\nhuge\tO\ndisappointment\tO\n.\tO\n\nReceived\tO\nall\tO\nfour\tO\nin\tO\ngood\tO\norder\tO\n;\tO\n\nThe\tO\ncomputer\tO\nfirst\tO\nstarted\tO\nmalfunctioning\tO\n3\tO\nmonths\tO\nafter\tO\npurchasing\tO\nit\tO\n.\tO\n\nthis\tO\nis\tO\nstarting\tO\noff\tO\ngood\tO\n.\tO\n\nThe\tO\nlarge\tO\nscreen\tB-aspectTerm\nalso\tO\nhelps\tO\nwhen\tO\nyou\tO\nare\tO\nworking\tO\nin\tO\ndesign\tB-aspectTerm\nbased\tI-aspectTerm\nprograms\tI-aspectTerm\nlike\tO\nAdobe\tB-aspectTerm\nCreative\tI-aspectTerm\nSuite\tI-aspectTerm\n.\tO\n\nThe\tO\nonly\tO\npro\tO\nto\tO\nthis\tO\ncomputer\tO\nis\tO\nit\tO\nwas\tO\nunder\tO\n$\tO\n600\tO\n!\tO\n\nMoral\tO\nof\tO\nthe\tO\nstory:-Do\tO\nnot\tO\nbuy\tO\nanything\tO\nfrom\tO\ncompanies\tB-aspectTerm\nthat\tO\ndo\tO\nnot\tO\nrespect\tO\ntheir\tO\ncustomers\tO\n.\tO\n\nThis\tO\nis\tO\nmy\tO\nfirst\tO\nDell\tO\nI\tO\nheard\tO\ntheir\tO\ncustomer\tB-aspectTerm\nservice\tI-aspectTerm\nwas\tO\nlacking\tO\nand\tO\nthat\tO\nthey\tO\nwere\tO\nworking\tO\non\tO\nimproving\tO\nit\tO\n!\tO\n\nAs\tO\nwell\tO\nas\tO\nhaving\tO\nthe\tO\nplug\tB-aspectTerm\nin\tO\nthe\tO\ncomputer\tO\ncome\tO\nloose\tO\n.\tO\n\nVery\tO\nsmall\tO\nand\tO\nportable\tO\nI\tO\n've\tO\nhad\tO\nthis\tO\nnetbook\tO\nabout\tO\n12\tO\nhrs\tO\nnow\tO\nand\tO\nIt\tO\n's\tO\nbetter\tO\nthan\tO\nexpected\tO\n.\tO\n\nShe\tO\nsaid\tO\nWal\tO\nMart\tO\nrants\tO\nand\tO\nraves\tO\nabouy\tO\ncarring\tO\nDell\tO\nbecause\tO\nit\tO\n's\tO\na\tO\nbig\tO\nname\tO\nbut\tO\nthey\tO\nare\tO\na\tO\npiece\tO\nof\tO\ngarbage\tO\n.\tO\n\nNOT\tO\nWITH\tO\nAPPLE\tO\n.\tO\n\nAfter\tO\n3\tO\npleasant\tO\nweeks\tO\nof\tO\nuse\tO\n,\tO\nthe\tO\nlaptop\tO\njust\tO\ndied\tO\n.\tO\n\nEach\tO\ntime\tO\ntaking\tO\nabout\tO\n1\tO\nday\tO\nor\tO\nso\tO\n.\tO\n\nSecond\tO\nHDD\tB-aspectTerm\ncover\tI-aspectTerm\nhas\tO\nwalls\tO\ninside\tO\nthat\tO\nneed\tO\nto\tO\nbe\tO\nbroken\tO\nif\tO\nyou\tO\nwhat\tO\nto\tO\ninstall\tO\none\tO\n.\tO\n\nIf\tO\nyou\tO\nwant\tO\nmore\tO\ninformation\tO\non\tO\nmacs\tO\nI\tO\nsuggest\tO\ngoing\tO\nto\tO\napple.com\tO\nand\tO\nheading\tO\ntowards\tO\nthe\tO\nmacbook\tO\npage\tO\nfor\tO\nmore\tO\ninformation\tO\non\tO\nthe\tO\napplications\tB-aspectTerm\n.\tO\n\nSo\tO\na\tO\ncouple\tO\nof\tO\nyears\tO\nlater\tO\n,\tO\nI\tO\nwas\tO\na\tO\ndumb\tO\ncollege\tO\ngirl\tO\nand\tO\nhad\tO\nto\tO\nhave\tO\nthe\tO\nwireless\tO\ninternet\tO\n.\tO\n\nThis\tO\nnetbook\tO\nwent\tO\nbad\tO\non\tO\nme\tO\nafter\tO\n3\tO\ndays\tO\n.\tO\n\nProbably\tO\nwo\tO\nn't\tO\nwork\tO\neither\tO\n.\tO\n\nGreat\tO\nproduct\tO\nby\tO\nApple\tO\nwith\tO\nthe\tO\nnew\tO\ngreat\tO\nlooking\tO\ndesign\tB-aspectTerm\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nkeyboard\tB-aspectTerm\n.\tO\n\nProbably\tO\nas\tO\ngood\tO\nas\tO\nyou\tO\ncan\tO\nget\tO\nin\tO\na\tO\nnetbook\tO\n,\tO\ndoes\tO\neverything\tO\nI\tO\nask\tO\nfor\tO\nand\tO\nhas\tO\nsome\tO\nvery\tO\ngood\tO\nunexpected\tO\npluses\tO\n.\tO\n\nOverall\tO\nI\tO\nam\tO\nvery\tO\nsatisfied\tO\nwith\tO\nthe\tO\npurchase\tO\n.\tO\n\nIn\tO\nmy\tO\nline\tO\nof\tO\nwork\tO\n,\tO\nI\tO\noften\tO\nhave\tO\nto\tO\ntake\tO\nwork\tO\nhome\tO\n,\tO\nand\tO\nthis\tO\nmakes\tO\nit\tO\nso\tO\neasy\tO\n.\tO\n\nThey\tO\ntold\tO\nme\tO\nto\tO\nreprogram\tO\nthe\tO\ncomputer\tO\n,\tO\nand\tO\nI\tO\ndid\tO\nn't\tO\nneed\tO\nto\tO\ndo\tO\nthat\tO\n,\tO\nand\tO\nI\tO\nlost\tO\npictures\tO\nof\tO\nmy\tO\noldests\tO\nfirst\tO\n2\tO\nyears\tO\nof\tO\nher\tO\nlife\tO\n.\tO\n\nI\tO\nuse\tO\niphoto\tB-aspectTerm\nall\tO\nthe\tO\ntime\tO\n,\tO\nwhich\tO\nis\tO\na\tO\ngreat\tO\nprogram\tB-aspectTerm\nfor\tO\nanyone\tO\nwho\tO\nis\tO\ninto\tO\nphotography\tO\n-\tO\namateurs\tO\nand\tO\nexperts\tO\nalike\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\nfor\tO\nmy\tO\nson\tO\nin\tO\n2007\tO\nfor\tO\nhis\tO\nChristmas\tO\npresent\tO\n.\tO\n\nIt\tO\ntook\tO\nso\tO\nmuch\tO\ntime\tO\n.\tO\n\nI\tO\nhate\tO\nit\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nn't\tO\nhuge\tO\n,\tO\nbut\tO\nthat\tO\ndoes\tO\nn't\tO\nmatter\tO\nwhen\tO\nI\tO\noutput\tO\nmedia\tO\nto\tO\nthe\tO\n50\tO\ninch\tO\nLCD\tO\nTV\tO\n.\tO\n\nI\tO\n'll\tO\nstick\tO\nto\tO\nTashiba\tO\n.\tO\n\nI\tO\nwill\tO\nhave\tO\nto\tO\npurchase\tO\nSpy\tB-aspectTerm\nware\tI-aspectTerm\nor\tO\nNortell\tB-aspectTerm\nfor\tO\nprivacy\tO\nprotection\tO\n.\tO\n\nYou\tO\nwill\tO\nnot\tO\nregret\tO\nbuying\tO\nsuch\tO\na\tO\ngreat\tO\nthing\tO\nlike\tO\nthis\tO\n!\tO\n\nI\tO\nwas\tO\nsaid\tO\nit\tO\n's\tO\nvideocard\tB-aspectTerm\n.\tO\n\nPlus\tO\nstylish\tO\n.\tO\n\nFor\tO\nthe\tO\nprice\tB-aspectTerm\nand\tO\nwhat\tO\nI\tO\nget\tO\nout\tO\nof\tO\nit\tO\nhas\tO\nexceeded\tO\nmy\tO\nexpectations\tO\n.\tO\n\nAnd\tO\n,\tO\nif\tO\nyou\tO\nare\tO\ngoing\tO\nto\tO\ndeal\tO\nwith\tO\nHP\tO\nbe\tO\ncareful\tO\n.\tO\n\nI\tO\ntook\tO\nthe\tO\ncomputer\tO\ninto\tO\nBest\tO\nBuy\tO\nwhere\tO\nI\tO\npurchased\tO\nit\tO\nand\tO\nthey\tO\nkept\tO\nit\tO\nover\tO\nnight\tO\nto\tO\nstudy\tO\nit\tO\n.\tO\n\nIf\tO\nyour\tO\ntime\tO\nis\tO\nworth\tO\nanything\tO\nto\tO\nyou\tO\n,\tO\nif\tO\nyou\tO\nare\tO\ntired\tO\nof\tO\nrebooting\tO\n,\tO\nreformatting\tO\n,\tO\nreinstalling\tO\n,\tO\ntrying\tO\nto\tO\nfind\tO\ndrivers\tB-aspectTerm\n,\tO\nif\tO\nyou\tO\nwant\tO\na\tO\ncomputer\tO\nto\tO\nwork\tO\nfor\tO\nyou\tO\nfor\tO\na\tO\nchange\tO\n,\tO\nmake\tO\nthe\tO\nchange\tO\nto\tO\nthis\tO\ncomputer\tO\n.\tO\n\nMy\tO\nMacBook\tO\nPro\tO\nis\tO\nno\tO\nexception\tO\n.\tO\n\nUnless\tO\nyou\tO\ndo\tO\nn't\tO\ncare\tO\nhow\tO\nlong\tO\nit\tO\ntakes\tO\nto\tO\nget\tO\ngoing\tO\n,\tO\nfind\tO\nsomething\tO\nelse\tO\n.\tO\n\n(\tO\nYou\tO\nmay\tO\nbe\tO\nreading\tO\none\tO\nnow\tO\n!\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\nwish\tO\nis\tO\nthe\tO\n15\tO\ninch\tO\nMacBook\tO\nPro\tO\nhas\tO\nmuch\tO\nbetter\tO\nspeakers\tB-aspectTerm\non\tO\nthe\tO\nside\tO\nof\tO\nthe\tO\nkeyboard\tB-aspectTerm\n.\tO\n\nI\tO\nwill\tO\nhave\tO\nto\tO\nsay\tO\nthat\tO\nI\tO\nlove\tO\nmy\tO\nMacBook\tO\nPro\tO\n!\tO\n\nIn\tO\nfact\tO\n,\tO\nhe\tO\nsaid\tO\n,\tO\nabout\tO\n10\tO\n%\tO\nof\tO\ntheir\tO\nproducts\tO\nfail\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nApple\tO\nproduct\tO\nthat\tO\nI\tO\nhave\tO\npurchased\tO\n.\tO\n\nNow\tO\n,\tO\nas\tO\neasy\tO\nas\tO\nit\tO\nis\tO\nto\tO\nuse\tO\n,\tB-aspectTerm\nand\tO\nI\tO\ndo\tO\nthink\tO\nit\tO\nis\tO\na\tO\ngreat\tO\nSTARTER\tO\nlaptop\tO\n.\tO\n\nThis\tO\ncauses\tO\nmy\tO\nwrist\tO\nto\tO\nscrape\tO\nup\tO\nagainst\tO\nit\tO\n.\tO\n\nEnough\tO\nsaid\tO\n.\tO\n\nSetting\tB-aspectTerm\nwould\tO\nchange\tO\nfor\tO\nsome\tO\nreason\tO\n,\tO\nthe\tO\nscreen\tB-aspectTerm\nsize\tI-aspectTerm\nwould\tO\nchange\tO\non\tO\nit\tO\n's\tO\nown\tO\n,\tO\nlike\tO\nthe\tO\npixel\tB-aspectTerm\nsizes\tI-aspectTerm\nand\tO\nwhatnot\tO\n.\tO\n\nIt\tO\nhad\tO\nsome\tO\nkind\tO\nof\tO\npre\tB-aspectTerm\ninstalled\tI-aspectTerm\nsoftware\tI-aspectTerm\nupdate\tI-aspectTerm\nthat\tO\ncompletely\tO\nshut\tO\nthe\tO\ncomputer\tO\ndown\tO\nwhen\tO\nyou\tO\nclicked\tO\nit\tO\n.\tO\n\nEver\tO\nsince\tO\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\n,\tO\nso\tO\nfar\tO\nI\tO\n've\tO\nexperience\tO\nnothing\tO\nbut\tO\nconstant\tO\nbreak\tO\ndowns\tO\nof\tO\nthe\tO\nlaptop\tO\nand\tO\nbad\tO\ncustomer\tB-aspectTerm\nservices\tI-aspectTerm\nI\tO\nreceived\tO\nover\tO\nthe\tO\nphone\tO\nwith\tO\ntoshiba\tB-aspectTerm\ncustomer\tI-aspectTerm\nservices\tI-aspectTerm\nhotlines\tO\n.\tO\n\nI\tO\ndo\tO\nnot\tO\nplan\tO\non\tO\ngoing\tO\nback\tO\n.\tO\n\nNo\tO\nlaptop\tO\nis\tO\nperfect\tO\n,\tO\nbut\tO\nsometimes\tO\nyou\tO\njust\tO\nfind\tO\na\tO\ncomputer\tO\nthat\tO\nworks\tO\nfor\tO\nyou\tO\n.\tO\n\nI\tO\nreally\tO\nlike\tO\nthe\tO\nMac\tO\n15.4\tO\nin\tO\n.\tO\nNotebook\tO\n,\tO\nbut\tO\nits\tO\nvery\tO\npricey\tO\n.\tO\n\nAlso\tO\n,\tO\nthe\tO\nspace\tB-aspectTerm\nbar\tI-aspectTerm\nmakes\tO\na\tO\nnoisy\tO\nclick\tO\nevery\tO\ntime\tO\nyou\tO\nuse\tO\nit\tO\n.\tO\n\niPhotos\tB-aspectTerm\nis\tO\nan\tO\nexcellent\tO\nprogram\tB-aspectTerm\nfor\tO\nstoring\tO\nand\tO\norganizing\tO\nphotos\tO\n.\tO\n\nOther\tO\nthan\tO\nthat\tO\nits\tO\na\tO\ngreat\tO\nperforming\tB-aspectTerm\nmachine\tO\nand\tO\nwell\tO\nmeets\tO\nall\tO\nmy\tO\nneeds\tO\nand\tO\nmore\tO\n.\tO\n\nWe\tO\nwere\tO\noccasional\tO\nMac\tO\nusers\tO\nbefore\tO\n,\tO\nbut\tO\nmost\tO\nrecently\tO\nowned\tO\na\tO\nbudget\tO\nPC\tO\nsince\tO\nit\tO\nis\tO\nwhat\tO\nwe\tO\ncould\tO\nafford\tO\n.\tO\n\nCalled\tO\ntech\tO\nsupport\tO\nand\tO\ngot\tO\nthe\tO\nusual\tO\nAcer\tO\n\"\tO\nWe\tO\ndo\tO\nn't\tO\nsupport\tO\nsoftware\tB-aspectTerm\nbut\tO\nfor\tO\n$\tO\n$\tO\n$\tO\nwe\tO\ncan\tO\nhelp\tO\nyou\tO\n\"\tO\nI\tO\nexplained\tO\nthere\tO\nwas\tO\nno\tO\nsoftware\tB-aspectTerm\ninvolved\tO\nin\tO\nbooting\tB-aspectTerm\n.\tO\n\nI\tO\nwould\tO\nnever\tO\ntell\tO\nanyone\tO\nto\tO\nbuy\tO\none\tO\neither\tO\n.\tO\n\nThe\tO\nprograms\tB-aspectTerm\nare\tO\ngreat\tO\n,\tO\nlike\tO\niphoto\tB-aspectTerm\n(\tO\nlove\tO\nthe\tO\nediting\tO\ncapabilities\tO\n)\tO\n,\tO\nimail\tB-aspectTerm\n(\tO\nwhich\tO\ncan\tO\nincorporate\tO\nwith\tO\nthe\tO\naddress\tO\nbook\tO\non\tO\nthe\tO\nipod\tO\nand\tO\nipad\tO\n)\tO\n,\tO\nimovie\tB-aspectTerm\n,\tO\netc\tO\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\ndid\tO\nn't\tO\nlearn\tO\nin\tO\nmy\tO\nresearch\tO\nwas\tO\nthe\tO\nsoftware\tB-aspectTerm\nI\tO\nwould\tO\nneed\tO\nlike\tO\nprivacy\tO\nprotection\tO\nand\tO\nwarranty\tO\nprotection\tO\n,\tO\nin\tO\ncase\tO\nit\tO\ngets\tO\nbroken\tO\n,\tO\nor\tO\ncrashes\tO\netc\tO\n.\tO\n\nI\tO\nca\tO\nn't\tO\nsay\tO\nenough\tO\ngood\tO\nfor\tO\nit\tO\n!\tO\n\nComfterbale\tO\nto\tO\nuse\tB-aspectTerm\nlight\tO\neasy\tO\nto\tO\ntransport\tB-aspectTerm\n.\tO\n\nThe\tO\nComputer\tO\nitself\tO\nis\tO\na\tO\ngood\tO\nproduct\tO\nbut\tO\nthe\tO\nrepair\tB-aspectTerm\ndepot\tI-aspectTerm\nstinks\tO\n.\tO\n\nI\tO\nthought\tO\nthe\tO\nprice\tB-aspectTerm\nwas\tO\ngreat\tO\nfor\tO\nthe\tO\nspecs\tB-aspectTerm\n.\tO\n\nI\tO\nwas\tO\ntired\tO\nof\tO\ngoing\tO\nwithout\tO\nmy\tO\nlaptop\tO\nevery\tO\nfew\tO\nweeks\tO\n.\tO\n\nthe\tO\nonly\tO\ndown\tO\nfall\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\nno\tO\ncd\tB-aspectTerm\ndrive\tI-aspectTerm\nbut\tO\ni\tO\nfound\tO\nthat\tO\nthey\tO\nare\tO\nvery\tO\ncheap\tO\nto\tO\nby\tO\nand\tO\nalso\tO\nvery\tO\nportable\tO\nmaking\tO\nthis\tO\nthe\tO\nbest\tO\nfriend\tO\nto\tO\nsomeone\tO\nwho\tO\nis\tO\nalways\tO\nlooking\tO\nfor\tO\nmore\tO\nspace\tO\nthen\tO\nthey\tO\nhave\tO\n.\tO\n\nSo\tO\n,\tO\nthe\tO\nhard\tB-aspectTerm\ndisk\tI-aspectTerm\ncapacity\tI-aspectTerm\nreally\tO\ndoes\tO\nn't\tO\nmatter\tO\nto\tO\nme\tO\n.\tO\n\nJust\tO\nfor\tO\na\tO\nstupid\tO\nCD\tO\n.\tO\n\nKeys\tB-aspectTerm\nstick\tO\nperiodically\tO\nand\tO\nI\tO\nhave\tO\nnt\tO\nhad\tO\nthe\tO\nlaptop\tO\nfor\tO\n45\tO\ndays\tO\nyet\tO\n.\tO\n\nIt\tO\ncrashes\tO\n,\tO\nand\tO\nwhen\tO\nit\tO\ngoes\tO\nflat\tO\n,\tO\nit\tO\njust\tO\nDIES\tO\n(\tO\nlike\tO\na\tO\nPC\tO\n,\tO\nmaybe\tO\nworse\tO\n)\tO\nand\tO\nI\tO\nloose\tO\nall\tO\nmy\tO\nopen\tO\ndocuments\tO\n!\tO\n\nI\tO\nalso\tO\nlike\tO\nthat\tO\nyou\tO\ncan\tO\nscroll\tO\ndown\tO\nin\tO\na\tO\nwindow\tO\nusing\tO\ntwo\tO\nfingers\tO\non\tO\nthe\tO\ntrackpad\tB-aspectTerm\n.\tO\n\nEverything\tO\nfrom\tO\nthe\tO\ndesign\tB-aspectTerm\nto\tO\nthe\tO\nOS\tB-aspectTerm\nis\tO\nsimple\tO\nand\tO\nto\tO\nthe\tO\npoint\tO\n.\tO\n\nI\tO\nam\tO\nnow\tO\nmaking\tO\na\tO\npoint\tO\nto\tO\navoid\tO\ntheir\tO\nproducts\tO\nand\tO\nI\tO\nhope\tO\nmy\tO\nexperience\tO\ncan\tO\nserve\tO\nas\tO\na\tO\nwarning\tO\nto\tO\nyou\tO\nas\tO\nwell\tO\n.\tO\n\nI'v\tO\nspent\tO\nas\tO\nmuch\tO\nfor\tO\nshipping\tB-aspectTerm\nas\tO\nI\tO\nwould\tO\nto\tO\nbuy\tO\na\tO\nnew\tO\nnetbook\tO\n--\tO\nof\tO\ncourse\tO\na\tO\ndifferent\tO\nbrand\tO\n.\tO\n\nI\tO\npersonally\tO\nlike\tO\nthe\tO\ngaming\tB-aspectTerm\nlook\tI-aspectTerm\nbut\tO\nneeded\tO\na\tO\nmachine\tO\nthat\tO\ndelivered\tO\ngaming\tB-aspectTerm\nperformance\tI-aspectTerm\nwhile\tO\nstill\tO\nlooking\tO\nprofessional\tO\nin\tO\nfront\tO\nof\tO\nmy\tO\ncustomers\tO\n.\tO\n\nThis\tO\njust\tO\nkeeps\tO\nhaving\tO\nit\tO\n's\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nreplaced\tO\n!\tO\n\nWhen\tO\nyou\tO\nlook\tO\nat\tO\nthe\tO\nspecs\tO\non\tO\nApple\tO\nproducts\tO\nin\tO\ncomparison\tO\nto\tO\na\tO\nDell\tO\nor\tO\na\tO\nHP\tO\n,\tO\nyes\tO\nthey\tO\ndo\tO\nseem\tO\nto\tO\noffer\tO\nless\tO\nfor\tO\na\tO\nhigher\tO\ncost\tB-aspectTerm\n.\tO\n\n\"\tO\nThen\tO\nI\tO\nproceed\tO\nto\tO\ntell\tO\nher\tO\nthat\tO\nI\tO\nchecked\tO\nout\tO\nother\tO\nretail\tO\nstores\tO\nthat\tO\ncarry\tO\nthe\tO\nnetbook\tO\nand\tO\nit\tO\nwas\tO\nn't\tO\nLIKE\tO\nTHAT\tO\n.\tO\n\nThen\tO\nthey\tO\nhad\tO\nme\tO\njump\tO\nthrough\tO\nmany\tO\nhoops\tO\nand\tO\nquestions\tO\nto\tO\nsee\tO\nif\tO\nthey\tO\ncould\tO\nfind\tO\nanother\tO\nway\tO\nto\tO\ninvalidate\tO\nme\tO\n.\tO\n\nThe\tO\nonly\tO\ndownfall\tO\nis\tO\nthe\tO\nvolume\tB-aspectTerm\ncontrol\tI-aspectTerm\n.\tO\n\nClearly\tO\n,\tO\nthere\tO\nis\tO\nsomething\tO\nwrong\tO\nwith\tO\nthe\tO\nproduct\tO\nand\tO\nLG\tO\ndid\tO\nn't\tO\ntake\tO\nup\tO\nthe\tO\nresponsibility\tO\n.\tO\n\nVery\tO\nfast\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nand\tO\nshut\tB-aspectTerm\ndown\tI-aspectTerm\n.\tO\n\nRight\tO\nout\tO\nof\tO\nthe\tO\nbox\tO\n,\tO\nthis\tO\nlittle\tO\nnetbook\tO\ndid\tO\neverything\tO\nI\tO\nasked\tO\nof\tO\nit\tO\n,\tO\nincluding\tO\nstreaming\tO\nthe\tO\neveryday\tO\nvideo\tO\nyou\tO\n're\tO\nbound\tO\nto\tO\nencounter\tO\nchecking\tO\nmail\tO\nand\tO\nwebsites\tO\n(\tO\nmy\tO\nbiggest\tO\ncomplaint\tO\npreviously\tO\n)\tO\n.\tO\n\nI\tO\nam\tO\nvery\tO\nhappy\tO\nwith\tO\nthis\tO\nlaptop\tO\n.\tO\n\nthis\tO\nlaptop\tO\nis\tO\ndurable\tO\nand\tO\nit\tO\nis\tO\neasy\tO\nto\tO\ntravel\tO\nwith\tO\n.\tO\n\nI\tO\nfinally\tO\ndecided\tO\non\tO\nthis\tO\nlaptop\tO\nbecause\tO\nit\tO\nwas\tO\nthe\tO\nright\tO\nprice\tB-aspectTerm\nfor\tO\nwhat\tO\nI\tO\nneed\tO\nit\tO\n.\tO\n\nWhat\tO\na\tO\nmistake\tO\n!\tO\n\nIf\tO\ninternet\tB-aspectTerm\nconnectivity\tI-aspectTerm\nis\tO\nimportant\tO\nI\tO\nwould\tO\nrecommend\tO\ngoing\tO\nwith\tO\na\tO\ndell\tO\nnet\tO\nbook\tO\nfor\tO\n50\tO\nbucks\tO\nmore\tO\n,\tO\nor\tO\nbuy\tO\na\tO\nUSB\tB-aspectTerm\nwireless\tI-aspectTerm\ncard\tI-aspectTerm\n.\tO\n\nI\tO\nhad\tO\nread\tO\nonline\tO\nthat\tO\nsome\tO\nusers\tO\nwere\tO\nhaving\tO\nsound\tB-aspectTerm\nproblems\tO\n.\tO\n\nMy\tO\nlast\tO\ncomputer\tO\n,\tO\na\tO\nToshiba\tO\n,\tO\ncost\tB-aspectTerm\nonly\tO\n$\tO\n400\tO\n,\tO\nand\tO\nworked\tO\nlike\tO\na\tO\ncharm\tO\nfor\tO\nmany\tO\nyears\tO\n.\tO\n\nIt\tO\ndischarges\tB-aspectTerm\ntoo\tO\nquickly\tO\n.\tO\n\nBut\tO\nto\tO\nbe\tO\nhonest\tO\n,\tO\nthe\tO\ncompatibility\tB-aspectTerm\nissues\tO\nand\tO\nthe\tO\nother\tO\nlittle\tO\nquirks\tO\nmake\tO\nme\tO\nthink\tO\nI\tO\nll\tO\nbuy\tO\na\tO\nPC\tO\nnext\tO\ntime\tO\n.\tO\n\nthree\tO\nyears\tO\nis\tO\na\tO\ndecent\tO\nlife\tO\n,\tO\nbut\tO\nthis\tO\nmust\tO\nmake\tO\nit\tO\nto\tO\ngraduation\tO\nand\tO\nbeyond\tO\n.\tO\n\nI\tO\nwork\tO\non\tO\na\tO\nPC\tO\nat\tO\nhome\tO\nand\tO\nhave\tO\nused\tO\nPc\tO\nall\tO\nthrough\tO\ncollege\tO\n.\tO\n\nTOSHIBA\tO\nWILL\tO\nNOT\tO\nACKNOWLEDGE\tO\nTHIS\tO\nPROBLEM\tO\n.\tO\n\nThen\tO\nit\tO\nceased\tO\ncharging\tB-aspectTerm\nat\tO\nall\tO\n.\tO\n\nAn\tO\nabsolutely\tO\nhateful\tO\nmachine\tO\nthat\tO\nno\tO\none\tO\nshould\tO\nget\tO\nof\tO\ntheir\tO\nown\tO\nfree\tO\nwill\tO\n.\tO\n\nI\tO\ndo\tO\nnot\tO\nexperience\tO\na\tO\nlot\tO\nof\tO\nheat\tO\ncoming\tO\nout\tO\nof\tO\nit\tO\n,\tO\nhowever\tO\nI\tO\nwould\tO\nhighly\tO\nsuggest\tO\npurchasing\tO\na\tO\nstand\tB-aspectTerm\nhowever\tO\n,\tO\ndue\tO\nto\tO\nthe\tO\nnature\tO\nof\tO\nthe\tO\ndesign\tB-aspectTerm\nof\tO\nthe\tO\nmacbook\tO\nas\tO\nit\tO\nis\tO\none\tO\nvery\tO\nlarge\tO\nheat\tB-aspectTerm\nsink\tI-aspectTerm\n.\tO\n\n*\tO\n=\tO\nWebcam\tB-aspectTerm\nis\tO\na\tO\nbit\tO\nlaggy\tO\n,\tO\nnot\tO\nthe\tO\ngreatest\tO\n.\tO\n\nI\tO\nam\tO\nnot\tO\nmuch\tO\nof\tO\na\tO\ncomputer\tO\ntechie\tO\n,\tO\nso\tO\nI\tO\ncan\tO\nunderstand\tO\nsome\tO\nof\tO\nthe\tO\ninternal\tO\nproblems\tO\n,\tO\nthough\tO\nI\tO\ndo\tO\nhave\tO\ntrend\tB-aspectTerm\nmicro\tI-aspectTerm\nas\tO\nan\tO\nantiviral\tB-aspectTerm\nprogram\tI-aspectTerm\n.\tO\n\nStay\tO\naway\tO\nfrom\tO\nHP\tO\n.\tO\n\nThe\tO\ncomputer\tO\ncontinued\tO\nto\tO\ngive\tO\nme\tO\nissues\tO\nand\tO\nin\tO\nLate\tO\nJune\tO\nit\tO\ncompletely\tO\ndied\tO\nagain\tO\nand\tO\nI\tO\ntried\tO\nto\tO\ncall\tO\nAcer\tO\nagain\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\nand\tO\nthey\tO\nrefused\tO\nto\tO\nhelp\tO\nme\tO\n,\tO\nthey\tO\nsaid\tO\nmy\tO\nwarrenty\tB-aspectTerm\nwas\tO\nup\tO\nand\tO\nhung\tO\nup\tO\non\tO\nme\tO\n.\tO\n\nI\tO\n've\tO\nhave\tO\nn't\tO\nhad\tO\nany\tO\nmajor\tO\nproblems\tO\nwith\tO\nthe\tO\nlaptop\tO\nexcept\tO\nthat\tO\nthe\tO\nplastic\tB-aspectTerm\npiece\tI-aspectTerm\nthat\tO\ncovers\tO\nthe\tO\nusb\tB-aspectTerm\nport\tI-aspectTerm\nwires\tI-aspectTerm\nhave\tO\nall\tO\ncome\tO\noff\tO\n.\tO\n\nWonderful\tO\nsleek\tO\ncase\tB-aspectTerm\ndesign\tI-aspectTerm\nis\tO\nonly\tO\non\tO\nthe\tO\noutside\tO\n.\tO\n\nIt\tO\nis\tO\nspeedy\tO\nwhen\tO\nconnected\tO\nwirelessly\tO\nto\tO\nany\tO\nnetwork\tO\nregardless\tO\nif\tO\nthe\tO\nconnection\tB-aspectTerm\nis\tO\nweak\tO\nor\tO\nnot\tO\n.\tO\n\nI\tO\nlike\tO\nit\tO\n!\tO\n\nThe\tO\npricing\tB-aspectTerm\nis\tO\nvery\tO\ncompetitive\tO\n.\tO\n\nso\tO\nwe\tO\ngot\tO\na\tO\ngood\tO\ndeal\tO\non\tO\nhsn\tO\nfor\tO\nan\tO\nascer\tO\nnotebook\tO\nand\tO\nwe\tO\nbought\tO\nit\tO\nfor\tO\nhim\tO\n.\tO\n\nConnecting\tO\nto\tO\nmy\tO\nwireless\tO\nrouter\tO\nvia\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nwireless\tI-aspectTerm\ntook\tO\nno\tO\ntime\tO\nat\tO\nall\tO\n.\tO\n\nIts\tO\nstill\tO\ngoing\tO\n.\tO\n\nThis\tO\ncomputer\tO\nis\tO\nexceptionally\tO\nthin\tO\nfor\tO\nit\tO\n's\tO\nscreen\tB-aspectTerm\nsize\tI-aspectTerm\nand\tO\nprocessing\tB-aspectTerm\npower\tI-aspectTerm\n.\tO\n\nThere\tO\nis\tO\nNO\tO\nway\tO\nI\tO\nwill\tO\nbuy\tO\na\tO\nLG\tO\nproduct\tO\nin\tO\nthe\tO\nfuture\tO\n.\tO\n\nI\tO\nhave\tO\nnot\tO\nhad\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\napplications\tB-aspectTerm\nquitting\tO\nor\tO\nfreezing\tO\n.\tO\n\nPrior\tO\nto\tO\nthis\tO\ncomputer\tO\n,\tO\nI\tO\nowned\tO\na\tO\nPowerBook\tO\nG4\tO\nfor\tO\n6\tO\nyears\tO\n(\tO\nquite\tO\na\tO\nlong\tO\ntime\tO\nfor\tO\na\tO\nlaptop\tO\n)\tO\n.\tO\n\nMaybe\tO\nthis\tO\nis\tO\nvirus\tO\nrelated\tO\n,\tO\nmaybe\tO\nnot\tO\n,\tO\nbut\tO\nthe\tO\ncomputer\tO\nhas\tO\nlocked\tO\nup\tO\nmany\tO\ntimes\tO\n,\tO\nand\tO\non\tO\ntwo\tO\noccasions\tO\n,\tO\nthe\tO\nscreen\tB-aspectTerm\nhas\tO\nsimply\tO\ngone\tO\nblack\tO\n.\tO\n\nThe\tO\nadvantages\tO\nof\tO\nowning\tO\n'\tO\na\tO\n'\tO\nmac\tO\nare\tO\nnumerous\tO\n.\tO\n\nI\tO\nchallenge\tO\nanyone\tO\nto\tO\nshow\tO\nproof\tO\nthat\tO\nthrough\tO\nanywhere\tO\nnear\tO\nnormal\tO\nuse\tO\ncan\tO\nget\tO\nmore\tO\nthan\tO\n2.5\tO\nhrs\tO\nout\tO\nof\tO\nit\tO\n.\tO\n\nUsing\tO\nthis\tO\nmachine\tO\nis\tO\nlike\tO\na\tO\nmild\tO\nform\tO\nof\tO\ntorture\tO\n.\tO\n\nThis\tO\nwiped\tO\nout\tO\nseveral\tO\nprograms\tB-aspectTerm\nthat\tO\nwere\tO\ninstalled\tO\non\tO\nthe\tO\ncomputer\tO\nwhen\tO\nit\tO\nwas\tO\nbought\tO\n.\tO\n\nOn\tO\nthe\tO\ntwelfth\tO\nday\tO\nthat\tO\nI\tO\nhad\tO\nthe\tO\nnotebook\tO\n,\tO\nI\tO\ndecided\tO\nto\tO\ngo\tO\nto\tO\nDell\tO\n's\tO\nwebsite\tO\nand\tO\nupdate\tO\nit\tO\n.\tO\n\nThe\tO\ncomputer\tO\nblinks\tO\nit\tO\nshuts\tO\noff\tO\nat\tO\nwill\tO\n.\tO\n\nExcellent\tO\nproduct\tO\nfor\tO\nthe\tO\nmoney\tO\n.\tO\n\nIt\tO\n's\tO\ngraphics\tB-aspectTerm\nare\tO\nn't\tO\nbad\tO\nat\tO\nall\tO\n,\tO\nfor\tO\nthe\tO\nlower\tO\nend\tO\nof\tO\nthe\tO\nMacBook\tO\nPro\tO\nspectrum\tO\n,\tO\neasily\tO\ncapable\tO\nof\tO\nrunning\tO\nStarCraft\tO\nII\tO\nand\tO\nother\tO\ngames\tO\nwith\tO\ncomparable\tO\ngraphics\tB-aspectTerm\n.\tO\n\nI\tO\nhave\tO\nVista\tB-aspectTerm\n,\tO\nso\tO\nI\tO\nam\tO\nunable\tO\nto\tO\ninstall\tB-aspectTerm\nand\tO\nuninstall\tB-aspectTerm\nsome\tO\nprograms\tO\n.\tB-aspectTerm\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nbright\tO\nand\tO\nvivid\tO\nand\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\nvery\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nvery\tO\nimportant\tO\nfor\tO\nuse\tO\nquick\tO\ntypers\tO\n.\tO\n\nI\tO\ncan\tO\ndo\tO\neverything\tO\nI\tO\ncould\tO\nbefore\tO\n,\tO\nonly\tO\nfaster\tO\nand\tO\nmore\tO\nefficiently\tO\n.\tO\n\nI\tO\ncalled\tO\nToshiba\tO\nand\tO\nthey\tO\nwant\tO\nme\tO\nto\tO\nbe\tO\nwithout\tO\nmy\tO\nlaptop\tO\nfor\tO\nabout\tO\ntwo\tO\nweeks\tO\nwhile\tO\nthey\tO\nlook\tO\nat\tO\nthe\tO\nproblem\tO\n.\tO\n\nthe\tO\nmouse\tB-aspectTerm\njumps\tO\naround\tO\nall\tO\nthe\tO\ntime\tO\nand\tO\nit\tO\nclicks\tO\nstuff\tO\ni\tO\ndo\tO\nnt\tO\nwant\tO\nit\tO\ntoo\tO\n.\tO\n\ni\tO\ndo\tO\nnt\tO\nunderstand\tO\nwhy\tO\ni\tO\nspent\tO\ntwice\tO\nas\tO\nmuch\tO\nto\tO\nget\tO\na\tO\nlaptop\tO\nrather\tO\nthan\tO\na\tO\ndesktop\tO\nwhen\tO\nmy\tO\nlap\tO\ntop\tO\nis\tO\ncompletely\tO\nimmoble\tO\n.\tO\n\nFor\tO\nthose\tO\nthat\tO\ncare\tO\nabout\tO\nnoise\tB-aspectTerm\nthis\tO\nthing\tO\ndoes\tO\nn't\tO\nreally\tO\nmake\tO\nany\tO\n;\tO\n\nHere\tO\nwe\tO\nare\tO\nanother\tO\nyear\tO\nlater\tO\nand\tO\nthe\tO\ncomputer\tO\nis\tO\ndoing\tO\nthe\tO\nsame\tO\nthing\tO\n.\tO\n\nDespite\tO\nthe\tO\nplethora\tO\nof\tO\nproblems\tO\n,\tO\nI\tO\nmanaged\tO\nto\tO\nuse\tO\ntechnological\tO\ntrickery\tO\nto\tO\nkeep\tO\nthe\tO\nmachine\tO\noperational\tO\nfor\tO\ntwo\tO\nyears\tO\n.\tO\n\nI\tO\nhad\tO\nmy\tO\nIWORKS\tB-aspectTerm\n,\tO\nItunes\tB-aspectTerm\n,\tO\nEmail\tO\n,\tO\nMS\tB-aspectTerm\nOffice\tI-aspectTerm\n,\tO\nnetwork\tO\nand\tO\nprinters\tO\nset\tO\nup\tO\nand\tO\ncompletely\tO\nworking\tO\nperfectly\tO\nwithin\tO\nan\tO\nhour\tO\n.\tO\n\nSimply\tO\namazing\tO\ncomputer\tO\n!\tO\n!\tO\n\nI\tO\nfirst\tO\npurchased\tO\nthis\tO\nDell\tO\nmodel\tO\n\"\tO\n1764\tO\n\"\tO\non\tO\nApril\tO\n6\tO\n,\tO\n201\tO\n\nThe\tO\nmacbooks\tO\nare\tO\nsmall\tO\nenough\tO\nto\tO\nbe\tO\nvery\tO\nportable\tO\nyet\tO\nhold\tO\ntons\tO\nof\tO\ninformation\tO\nand\tO\nperformance\tB-aspectTerm\n.\tO\n\nTwo\tO\ntimes\tO\nwith\tO\nin\tO\none\tO\nmonth\tO\n.\tO\n\nThe\tO\nonly\tO\ndownfall\tO\nis\tO\na\tO\nlot\tO\nof\tO\nthe\tO\nsoftware\tB-aspectTerm\nI\tO\nhave\tO\nwo\tO\nn't\tO\nwork\tO\nwith\tO\nMac\tO\nand\tO\niWork\tB-aspectTerm\nis\tO\nnot\tO\nworth\tO\nthe\tO\nprice\tB-aspectTerm\nof\tO\nit\tO\n.\tO\n\nWaited\tO\non\tO\ngetting\tO\nthis\tO\ncomputer\tO\n,\tO\nbut\tO\nit\tO\nhas\tO\nbeen\tO\na\tO\ngreat\tO\nchange\tO\n.\tO\n\nFor\tO\nmy\tO\nburn\tO\nthigh\tO\nwhich\tO\nhas\tO\nput\tO\na\tO\npermanent\tO\nmark\tO\non\tO\nmy\tO\nskin\tO\n(\tO\nit\tO\nhappened\tO\n7\tO\nmonths\tO\nago\tO\n)\tO\nthey\tO\noffered\tO\nme\tO\nan\tO\nITouch\tO\n8Gig\tO\n(\tO\nyou\tO\nknow\tO\nit\tO\nis\tO\na\tO\nbit\tO\ninsulating\tO\nwhen\tO\na\tO\ncompany\tO\nthis\tO\nrich\tO\n,\tO\noffer\tO\na\tO\nloyal\tO\ncustomer\tO\nlike\tO\nme\tO\n,\tO\na\tO\nbottom\tO\nof\tO\ntheir\tO\nproduct\tO\nline\tO\nas\tO\na\tO\ngift\tO\nfor\tO\nevents\tO\nlike\tO\nthis\tO\n)\tO\n.\tO\n\nWhenever\tO\ntried\tO\nto\tO\nturn\tO\nit\tO\non\tO\n,\tO\nit\tO\nwould\tO\nrestart\tO\nas\tO\nsoon\tO\nas\tO\nthe\tO\nBIOS\tB-aspectTerm\nlaunched\tO\nWindows\tB-aspectTerm\n(\tO\nor\tO\nWinblows\tO\n,\tO\nas\tO\nI\tO\nlike\tO\not\tO\ncall\tO\nit\tO\n)\tO\n.\tO\n\nBUT\tO\nthere\tO\n's\tO\nthis\tO\napplication\tB-aspectTerm\ncalled\tO\nBoot\tB-aspectTerm\nCamp\tI-aspectTerm\nwhich\tO\nallows\tO\nyou\tO\nto\tO\nadd\tO\nanother\tO\nOS\tB-aspectTerm\nX\tI-aspectTerm\nlike\tO\nWindows\tB-aspectTerm\n.\tO\n\nThe\tO\nmousepad\tB-aspectTerm\nis\tO\na\tO\nhuge\tO\npain\tO\nin\tO\nthe\tO\narse\tO\n!\tO\n\nI\tO\nhope\tO\nto\tO\nedit\tO\nthis\tO\nin\tO\nthe\tO\nnext\tO\nfew\tO\nhours\tO\n,\tO\nI\tO\nam\tO\ngoing\tO\nto\tO\ntry\tO\nto\tO\ninstall\tO\nmy\tO\nown\tO\ncopy\tO\nof\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\n.\tO\n\nIf\tO\nit\tO\n's\tO\nnot\tO\nshipped\tO\non\tO\nthe\tO\nnext\tO\nbusiness\tO\nday\tO\n,\tO\ncalled\tO\non\tO\na\tO\nFriday\tO\nthey\tO\nare\tO\nclosed\tO\non\tO\nweekends\tO\n,\tO\nwhat\tO\nwas\tO\nthe\tO\nnext\tO\nstep\tO\n.\tO\n\n)\tO\nI\tO\nalso\tO\npurchased\tO\nApplecare\tO\nfor\tO\n$\tO\n300\tO\n,\tO\nwhich\tO\nis\tO\na\tO\nthree\tO\nyear\tO\nextended\tO\nwarranty\tB-aspectTerm\n,\tI-aspectTerm\nsince\tO\nI\tO\nve\tO\nnever\tO\nseen\tO\nany\tO\nlaptop\tO\nthat\tO\nlasted\tO\nmore\tO\nthan\tO\ntwo\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nthe\tO\nnetbook\tO\nfor\tO\n2\tO\nmonths\tO\nand\tO\nI\tO\nlove\tO\nit\tO\n,\tO\nI\tO\nread\tO\nsome\tO\nreviews\tO\nthat\tO\nsay\tO\nnetbooks\tO\nare\tO\nslow\tO\nbut\tO\nit\tO\ndoes\tO\nnot\tO\nseem\tO\nany\tO\nslower\tO\nthan\tO\nthe\tO\nother\tO\ncomputers\tO\nI\tO\nuse\tO\n.\tO\n\nI\tO\nrun\tO\nwindows\tB-aspectTerm\nvia\tO\nbootcamp\tB-aspectTerm\nfor\tO\nthe\tO\ncouple\tO\nprograms\tB-aspectTerm\nI\tO\ndo\tO\nnot\tO\nwant\tO\nto\tO\nbuy\tO\na\tO\nmac\tO\nversion\tO\nof\tO\n,\tO\nlike\tO\nmy\tO\ncad\tB-aspectTerm\nprograms\tI-aspectTerm\n.\tO\n\nC'mon\tO\n,\tO\nLG\tO\n.\tO\n\nWhenever\tO\nI\tO\ncall\tO\nDell\tO\nabout\tO\nan\tO\nunrelated\tO\nproblem\tO\n,\tO\nthey\tO\nask\tO\nme\tO\nif\tO\nmy\tO\nlaptop\tO\nis\tO\nrunning\tO\nslowly\tO\nand\tO\nif\tO\nI\tO\n'd\tO\nlike\tO\nto\tO\npurchase\tO\nmore\tO\nmemory\tB-aspectTerm\nfor\tO\n$\tO\n75\tO\n.\tO\n\nsince\tO\nthen\tO\ni\tO\nhave\tO\nhad\tO\nminor\tO\nproblems\tO\nwith\tO\nslow\tO\noperation\tO\n.\tB-aspectTerm\n\nIf\tO\nyou\tO\nfaintly\tO\ncome\tO\nclose\tO\nto\tO\ntouching\tO\nthis\tO\nthing\tO\nwhile\tO\ntyping\tO\n,\tO\nall\tO\ncraziness\tO\nmay\tO\nbreak\tO\nloose\tO\n.\tO\n\nRegistration/1st\tO\nuse\tB-aspectTerm\nis\tO\neasy\tO\n.\tO\n\nI\tO\nlove\tO\nthis\tO\nlaptop\tO\n,\tO\nand\tO\nuse\tO\nit\tO\neveryday\tO\nto\tO\ndo\tO\nsomething\tO\n,\tO\nand\tO\nnever\tO\nlets\tO\nme\tO\ndown\tO\n.\tO\n\nFinally\tO\nwas\tO\nable\tO\nto\tO\nreach\tO\na\tO\nyoung\tO\nlady\tO\nin\tO\nCalifornia\tO\nand\tO\nordered\tO\nthe\tO\nmachine\tO\nand\tO\nwas\tO\nsubsequently\tO\ngiven\tO\na\tO\ndelivery\tO\ndate\tO\n.\tO\n\nI\tO\ndefinitely\tO\nwill\tO\nbuy\tO\na\tO\nMac\tO\nagain\tO\nif\tO\nand\tO\nwhen\tO\nthis\tO\ncomputer\tO\never\tO\nfails\tO\n.\tO\n\nThe\tO\nToshiba\tO\nMini\tO\nNotebook\tO\n,\tO\nModel\tO\nNB\tO\n305-N410BL\tO\n,\tO\nis\tO\na\tO\ngreat\tO\nlittle\tO\ncomputer\tO\n.\tO\n\nTake\tO\nyour\tO\ntime\tO\nand\tO\ngo\tO\nthrough\tO\nthe\tO\ntutorials\tB-aspectTerm\npatiently\tO\n.\tO\n\nSo\tO\nif\tO\nanyones\tO\nlooking\tO\nto\tO\nbuy\tO\na\tO\ncomputer\tO\nor\tO\nlaptop\tO\nyou\tO\nshould\tO\nstay\tO\nfar\tO\nfar\tO\naway\tO\nfrom\tO\nany\tO\nthat\tO\nhave\tO\nthe\tO\nname\tO\nTOSHIBA\tO\non\tO\nit\tO\n...\tO\n\n(\tO\nI\tO\n'm\tO\nan\tO\nexcellent\tO\ntouch\tO\ntypist\tO\n,\tO\nand\tO\nmy\tO\nhands\tO\nare\tO\nvery\tO\nsensitive\tO\n,\tO\ntoo\tO\n.\tO\n\nThis\tO\ntime\tO\nthe\tO\nmouse\tO\npad\tB-aspectTerm\nand\tI-aspectTerm\nright\tO\nclick\tB-aspectTerm\nkey\tI-aspectTerm\nwould\tI-aspectTerm\nn't\tO\nwork\tO\n!\tO\n\nEVENTUALLY\tO\nwe\tO\npushed\tO\nhard\tO\nenough\tO\nto\tO\nconvince\tO\nthem\tO\nthat\tO\nthis\tO\nwas\tO\nthe\tO\nMACHINE\tO\nthat\tO\nwas\tO\ncausing\tO\nthe\tO\nproblems\tO\n.\tO\n\nThe\tO\nfirst\tO\nfull\tB-aspectTerm\ncharge\tI-aspectTerm\nof\tO\nthis\tO\nbattery\tB-aspectTerm\ngot\tO\nme\tO\nonly\tO\nabout\tO\n2\tO\nfull\tO\nhours\tO\n.\tO\n\nI\tO\nbought\tO\na\tO\ncordless\tB-aspectTerm\nmouse\tI-aspectTerm\nfor\tO\nit\tO\n,\tO\nbut\tO\ndo\tO\nn't\tO\nalways\tO\ntake\tO\nit\tO\nout\tO\n;\tO\n\nWhen\tO\nI\tO\ngot\tO\nit\tO\n,\tO\nI\tO\nimmediately\tO\nnoticed\tO\nthat\tO\nit\tO\nwas\tO\nquite\tO\nheavy\tO\nand\tO\nthick\tO\nand\tO\nnot\tO\nreally\tO\nattractive\tO\n.\tO\n\nIt\tO\nis\tO\nsleek\tO\n,\tO\nsmooth\tO\n,\tO\nand\tO\nlightweight\tO\n.\tO\n\ni\tO\nam\tO\na\tO\nhuge\tO\ncomputer\tO\nperson\tO\ni\tO\nlove\tO\nanykind\tO\nof\tO\ncomputer\tO\nthat\tO\nworks\tO\nwell\tO\n,\tO\nbut\tO\nwhen\tO\ni\tO\ngot\tO\nthis\tO\none\tO\ni\tO\nwas\tO\nso\tO\nhappy\tO\nwith\tO\nthe\tO\nway\tO\nit\tO\nworks\tO\nand\tO\nhow\tO\nit\tO\nruns\tB-aspectTerm\nits\tO\namazing\tO\n.\tO\n\nIt\tO\ntook\tO\nToshiba\tB-aspectTerm\ntech\tI-aspectTerm\nsupport\tI-aspectTerm\n4\tO\ncalls\tO\nand\tO\n4\tO\ndifferent\tO\ntechs\tB-aspectTerm\nto\tO\ncorrect\tO\nthe\tO\nproblem\tO\n.\tO\n\nThey\tO\nonly\tO\nstay\tO\ncharged\tB-aspectTerm\na\tO\nlittle\tO\nover\tO\nan\tO\nhour\tO\n.\tO\n\nNow\tO\nthey\tO\nare\tO\nbelievers\tO\nin\tO\nthe\tO\nproduct\tO\n.\tO\n\nHad\tO\nto\tO\nhave\tO\nthis\tO\ncomputer\tO\nrepaired\tO\ntwice\tO\nin\tO\nthe\tO\nfirst\tO\n5\tO\nmonths\tO\nafter\tO\npurchasing\tO\nit\tO\n.\tO\n\nHewlett\tO\nPackard\tO\nHP\tO\nPavillion\tO\nDV6000\tO\nLaptop\tO\nis\tO\nthe\tO\nworst\tO\nlaptop\tO\nwe\tO\nhave\tO\never\tO\nbought\tO\n.\tO\n\nI\tO\nhad\tO\nnever\tO\nowned\tO\na\tO\nMac\tO\nbefore\tO\n;\tO\n\nThe\tO\n4\tO\nUSB\tB-aspectTerm\nports\tI-aspectTerm\nare\tO\nnice\tO\n,\tO\nbut\tO\nthe\tO\ntwo\tO\non\tO\nthe\tO\nside\tO\nonly\tO\nwork\tO\nnow\tO\nand\tO\nthen\tO\n.\tO\n\nI\tO\ncould\tO\nnot\tO\nfind\tO\na\tO\nphone\tO\nnumber\tO\nanywhere\tO\nto\tO\ncall\tO\nan\tO\nactual\tO\nlive\tO\nperson\tO\nfor\tO\ntech\tO\nsupport\tB-aspectTerm\nand\tI-aspectTerm\nhad\tO\nto\tO\nresult\tO\nthe\tO\ntheir\tO\nonline\tO\nchat\tB-aspectTerm\n.\tI-aspectTerm\n\ni\tO\ntry\tO\nto\tO\nuse\tO\nit\tO\ntoday\tO\nand\tO\nI\tO\nca\tO\nn't\tO\nlogon\tO\n.\tO\n\nKeyboard\tB-aspectTerm\ncould\tO\nuse\tO\nsome\tO\ntrimming\tO\n.\tO\n\nThe\tO\nbottom\tO\n-\tO\nline\tO\nis\tO\nthat\tO\nthis\tO\nlaptop\tO\njust\tO\nis\tO\nn't\tO\nworth\tO\nit\tO\n.\tO\n\nI\tO\nreturned\tO\nthe\tO\ncomputer\tO\nto\tO\nHP\tO\nand\tO\nthey\tO\nkept\tO\nit\tO\nfor\tO\n3\tO\nmonths\tO\n.\tO\n\nIts\tO\nwhite\tO\ncolor\tB-aspectTerm\nis\tO\nstylish\tO\nfor\tO\ncollege\tO\nstudents\tO\nand\tO\neasy\tO\nto\tO\ntake\tO\nto\tO\ncarry\tO\nand\tO\ntake\tO\nto\tO\nclasses\tO\n.\tO\n\nReturned\tO\nlaptop\tO\nfor\tO\nrepair\tO\na\tO\n2nd\tO\ntime\tO\nand\tO\nit\tO\ncame\tO\nback\tO\nwith\tO\nobvious\tO\nphysical\tO\ndamage\tO\n(\tO\nkeyboard\tB-aspectTerm\nbulging\tO\nand\tO\nspeaker\tB-aspectTerm\ngrill\tI-aspectTerm\npressed\tO\nin\tO\n)\tO\n,\tO\nbuttons\tB-aspectTerm\nnot\tO\nworking\tO\nand\tO\nUSB\tB-aspectTerm\nports\tI-aspectTerm\ninoperative\tO\n.\tO\n\nWhen\tO\nI\tO\nam\tO\nnext\tO\nto\tO\nmy\tO\nrouter\tO\non\tO\nmy\tO\nHP\tO\nI\tO\nget\tO\nfull\tB-aspectTerm\nservice\tI-aspectTerm\n,\tO\non\tO\nmy\tO\nEee\tO\nPC\tO\nI\tO\nget\tO\n3\tO\nbars\tO\n.\tO\n\nI\tO\ngot\tO\nassurances\tO\nfrom\tO\n2\tO\ndifferent\tO\npeople\tO\nthat\tO\nthe\tO\nremaining\tO\n10\tO\nmonths\tO\nof\tO\nmy\tO\nwarranty\tB-aspectTerm\nwould\tO\ntransfer\tO\nto\tO\nthe\tO\nnew\tO\ncomputer\tO\n.\tO\n\nPretty\tO\ndisappointed\tO\nabout\tO\nthis\tO\nproduct\tO\n.\tO\n\nThe\tO\nletter\tB-aspectTerm\nA\tI-aspectTerm\nstopped\tO\nworking\tO\nafter\tO\nthe\tO\nfirst\tO\nweek\tO\n.\tO\n\nBy\tO\nthe\tO\ntime\tO\nI\tO\nwas\tO\nfinally\tO\nable\tO\nto\tO\nget\tO\na\tO\nwork\tO\norder\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\nI\tO\nhad\tO\nbeen\tO\nwithout\tO\nmy\tO\ncomputer\tO\nfor\tO\nalmost\tO\na\tO\nweek\tO\nwhile\tO\nI\tO\nwas\tO\nan\tO\nOnline\tO\nCollege\tO\nStudent\tO\n,\tO\nso\tO\nit\tO\nwas\tO\nvery\tO\ninconvenient\tO\nand\tO\nI\tO\nhad\tO\nto\tO\nsend\tO\nit\tO\noff\tO\nand\tO\nbe\tO\nwithout\tO\nit\tO\nwhile\tO\nit\tO\nwas\tO\nbeing\tO\nfixed\tO\nalso\tO\n.\tO\n\nIt\tO\nout\tO\nperforms\tO\nany\tO\nother\tO\nlaptop\tO\non\tO\nthe\tO\nmarket\tO\ntoday\tO\n.\tO\n\nThis\tO\nis\tO\nwhat\tO\nI\tO\ncall\tO\na\tO\ngood\tO\nafter\tB-aspectTerm\nsales\tI-aspectTerm\nservice\tI-aspectTerm\n.\tO\n\nMaybe\tO\nit\tO\n's\tO\nAcer\tO\n,\tO\nmaybe\tO\nit\tO\n's\tO\nMSFT\tO\n.\tO\n\nSo\tO\nif\tO\nyou\tO\nwant\tO\na\tO\ngood\tO\nmachine\tO\nthat\tO\ndoes\tO\nalmost\tO\nanything\tO\nthis\tO\nis\tO\nthe\tO\none\tO\n,\tO\nif\tO\nyou\tO\nwant\tO\na\tO\nlow\tO\nbudget\tO\ncomputer\tO\nthen\tO\nlook\tO\nat\tO\nthe\tO\nother\tO\ngreat\tO\nbrands\tO\nBest\tO\nBuy\tO\nsells\tO\n.\tO\n\nI\tO\ntook\tO\noff\tO\na\tO\nstar\tO\nbecause\tO\nthe\tO\nmachine\tO\nhas\tO\na\tO\nlot\tO\nof\tO\njunk\tO\nsoftware\tB-aspectTerm\non\tO\nit\tO\n.\tO\n\nI\tO\nwould\tO\nbuy\tO\none\tO\nof\tO\nthese\tO\nfor\tO\nevery\tO\nperson\tO\nin\tO\nmy\tO\noffice\tO\nif\tO\nI\tO\ncould\tO\n.\tO\n\nWith\tO\nwhat\tO\nI\tO\ndo\tO\nknow\tO\nhow\tO\nto\tO\ndo\tO\n,\tO\nthe\tO\ncomputer\tO\nworks\tB-aspectTerm\nbeautiful\tO\n.\tO\n\nHAVING\tO\nHAD\tO\nEXPERIENCE\tO\nWITH\tO\nA\tO\nTOSHIBA\tO\nLAPTOP\tO\n,\tO\nI\tO\nWAS\tO\nDISAPPOINTED\tO\nTO\tO\nFIND\tO\nTHAT\tO\nTHE\tO\nTOSHIBA\tO\nNB305\tO\nLAPTOP\tO\nHAS\tO\nMAJOR\tO\nPROBLEMS\tO\n.\tO\n\nTried\tO\nto\tO\nmake\tO\na\tO\nrecovey\tB-aspectTerm\ndisk\tI-aspectTerm\nwould\tO\nnt\tO\nget\tO\npassed\tO\nthe\tO\nfirst\tO\nrecovery\tB-aspectTerm\ndisk\tI-aspectTerm\n.\tO\n\nMost\tO\neverything\tO\nis\tO\nfine\tO\nwith\tO\nthis\tO\nmachine\tO\n:\tO\nspeed\tB-aspectTerm\n,\tO\ncapacity\tB-aspectTerm\n,\tO\nbuild\tB-aspectTerm\n.\tO\n\nI\tO\nhave\tO\nnever\tO\nhad\tO\nit\tO\ncrash\tO\n,\tO\nrandomly\tO\nturn\tO\noff\tO\n,\tO\n\nFor\tO\nthe\tO\nsame\tO\nprice\tB-aspectTerm\n,\tO\nyou\tO\nget\tO\na\tO\nlot\tO\nmore\tO\nin\tO\nthe\tO\nAsus\tO\n....\tO\n1920x1080\tO\nres\tO\n.\tO\n\nI\tO\nmade\tO\na\tO\nphoto\tO\nbook\tO\nas\tO\na\tO\ngift\tO\n,\tO\non\tO\nmy\tO\ncomputer\tO\n,\tO\npushed\tO\n\"\tO\nBuy\tO\n\"\tO\nand\tO\nit\tO\ndrew\tO\nfrom\tO\nmy\tO\niTunes\tB-aspectTerm\naccount\tO\nand\tO\nsent\tO\nthe\tO\nbook\tO\nto\tO\nmy\tO\nhouse\tO\n,\tO\nthe\tO\nbook\tO\nwas\tO\nof\tO\nperfect\tO\nquality\tO\n-\tO\nexactly\tO\nhow\tO\nI\tO\nhad\tO\ncreated\tO\nit\tO\nand\tO\nlooked\tO\nbetter\tO\nthan\tO\nI\tO\nhad\tO\neven\tO\nimagined\tO\n.\tO\n\nI\tO\nuse\tO\nthis\tO\nfor\tO\nmy\tO\ntutoring\tO\nbusiness\tO\n,\tO\nand\tO\nsince\tO\nI\tO\n'm\tO\nalways\tO\nbouncing\tO\nfrom\tO\nstudent\tO\nto\tO\nstudent\tO\n,\tO\nit\tO\nis\tO\nideal\tO\nfor\tO\nportability\tB-aspectTerm\nand\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n(\tO\nyes\tO\n,\tO\nit\tO\ngets\tO\nthe\tO\n8\tO\nhours\tO\nas\tO\nadvertised\tO\n!\tO\n)\tO\n.\tO\n\nIt\tO\nis\tO\nin\tO\nthe\tO\nbest\tO\ncondition\tO\nand\tO\nhas\tO\na\tO\nreally\tO\nhigh\tO\nquality\tB-aspectTerm\n.\tO\n\nWhen\tO\nit\tO\ncome\tO\ntime\tO\nfor\tO\nwarranty\tB-aspectTerm\nservice\tI-aspectTerm\nto\tI-aspectTerm\nToshiba\tI-aspectTerm\nyou\tO\ndo\tO\nn't\tO\nmatter\tO\n.\tO\n\nHowever\tO\nthe\tO\nfrozen\tO\nscreens\tO\nkept\tB-aspectTerm\nhappening\tO\n.\tO\n\nI\tO\nve\tO\nowned\tO\nApple\tO\ncomputers\tO\nand\tO\nlaptops\tO\nfor\tO\nas\tO\nlong\tO\nas\tO\ni\tO\ncould\tO\nremember\tO\n.\tO\n\nAt\tO\nleast\tO\nthose\tO\ncomputers\tO\ndid\tO\nn't\tO\njust\tO\ndie\tO\non\tO\nme\tO\nlike\tO\nthis\tO\none\tO\n.\tO\n\nIt\tO\n's\tO\nA\tO\nMAC\tO\n!\tO\n!\tO\n\ni\tO\nhad\tO\nthe\tO\nbulk\tO\nof\tO\nproblems\tO\nwith\tO\nmy\tO\nlap\tO\ntop\tO\nwithin\tO\nthe\tO\nfirst\tO\nsix\tO\nmonths\tO\n.\tO\n\nThis\tO\nis\tO\nmy\tO\nfirst\tO\nLG\tO\nproduct\tO\n.\tO\n\nIt\tO\nis\tO\nshort\tO\non\tO\nspace\tB-aspectTerm\n,\tO\nand\tO\ndownloads\tB-aspectTerm\nalways\tO\nhad\tO\nproblems\tO\nbeing\tO\ncompleted\tO\n,\tO\nor\tO\nwere\tO\nsaid\tO\nto\tO\nbe\tO\n'\tO\ncorrupted\tO\n'\tO\n.\tO\n\n3\tO\n)\tO\nHorrible\tO\ncustomer\tB-aspectTerm\nsupport\tI-aspectTerm\n\nThe\tO\nLED\tB-aspectTerm\nbacklit\tI-aspectTerm\ndisplay\tI-aspectTerm\nmakes\tO\nmy\tO\npictures\tO\npop\tO\nso\tO\nmuch\tO\nmore\tO\n.\tO\n\nvery\tO\nvery\tO\nslow\tO\nlaptop\tO\n.\tO\n\nI\tO\n'm\tO\ngoing\tO\nback\tO\nto\tO\nDELL\tO\n.\tO\n\nWith\tO\nwhat\tO\nI\tO\npaid\tO\nfor\tO\nthis\tO\ncomputer\tO\nit\tO\nshould\tO\nhave\tO\nhad\tO\neverything\tO\non\tO\nit\tO\n.\tO\n\nApple\tO\nis\tO\nalways\tO\ngreat\tO\nabout\tO\nthe\tO\naesthetics\tB-aspectTerm\nof\tO\nthings\tO\n,\tO\nthey\tO\nalways\tO\ncome\tO\nup\tO\nwith\tO\ngood\tO\nlooking\tO\nproducts\tO\n.\tO\n\nI\tO\nwent\tO\nto\tO\nmy\tO\nlocal\tO\nBest\tO\nBuy\tO\nlooking\tO\nfor\tO\na\tO\nnew\tO\nlaptop\tO\nsince\tO\nmine\tO\nbroke\tO\n.\tO\n\nRuns\tB-aspectTerm\nsmooth\tO\nand\tO\nquick\tO\n.\tO\n\nNot\tO\na\tO\nbad\tO\nlaptop\tO\n,\tO\nit\tO\n's\tO\na\tO\nbit\tO\nslow\tO\n,\tO\nbut\tO\ngets\tO\nthe\tO\njob\tO\ndone\tO\n.\tO\n\nHonestly\tO\n,\tO\nI\tO\nspent\tO\nmore\tO\ntime\tO\nwaiting\tO\nfor\tO\nit\tO\nto\tO\nunfreeze\tO\nthen\tO\nactually\tO\ndoing\tO\nwhat\tO\nI\tO\ngot\tO\non\tO\nthere\tO\nfor\tO\n!\tO\n\nThis\tO\na\tO\nstarter\tO\nnotebook\tO\n.\tO\n\nNo\tO\nI\tO\nam\tO\ngenerous\tO\ncalling\tO\nit\tO\nslow\tO\n.\tO\n\nThe\tO\ndownside\tO\nto\tO\nthis\tO\nnetbook\tO\nis\tO\npretty\tO\nmuch\tO\nthe\tO\nsame\tO\nfor\tO\nany\tO\nnetbook\tO\n:\tO\nscreen\tB-aspectTerm\nsize\tI-aspectTerm\nis\tO\nnot\tO\nsomething\tO\nI\tO\n'd\tO\nstare\tO\nat\tO\nfor\tO\nthe\tO\nentire\tO\n10\tO\n-\tO\n11\tO\nhours\tO\nof\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nfive\tO\ndays\tO\na\tO\nweek\tO\n.\tO\n\nThe\tO\ngraphics\tB-aspectTerm\nare\tO\ngreat\tO\n.\tO\n\nAll\tO\n-\tO\nin\tO\n-\tO\nall\tO\n,\tO\nI\tO\nwould\tO\ndefinitely\tO\nrecommend\tO\nthis\tO\nproduct\tO\nfor\tO\nnearly\tO\neveryone\tO\n.\tO\n\nin\tO\n5\tO\nmonths\tO\nthe\tO\nconnect\tB-aspectTerm\nquality\tI-aspectTerm\ngot\tO\nworse\tO\nand\tO\nworse\tO\n.\tO\n\nThe\tO\nbig\tO\nscreen\tB-aspectTerm\nallows\tO\nyou\tO\nto\tO\nenjoy\tO\nwatching\tO\nmovies\tO\n,\tO\npictures\tO\nand\tO\netc\tO\n!\tO\n\nthe\tO\nheadphone\tB-aspectTerm\nand\tO\nmic\tB-aspectTerm\njack\tI-aspectTerm\nare\tO\nin\tO\nfront\tO\nof\tO\ntouch\tB-aspectTerm\n-\tI-aspectTerm\npad\tI-aspectTerm\nmaking\tO\nthe\tO\ntouch\tB-aspectTerm\n-\tI-aspectTerm\npad\tI-aspectTerm\nhard\tO\nto\tO\nuse\tO\nwhen\tO\nusing\tO\nheadphones\tB-aspectTerm\n/\tO\nmic\tB-aspectTerm\n,\tO\nnot\tO\nto\tO\nmention\tO\nthe\tO\nlaptop\tO\nwas\tO\ndesigned\tO\nfor\tO\nright\tO\nhanded\tO\nperson\tO\n.\tO\n\nFor\tO\nthe\tO\n[\tO\n$\tO\n]\tO\nprice\tB-aspectTerm\n(\tO\nspecial\tO\noffer\tO\n)\tO\nthis\tO\nis\tO\na\tO\ngreat\tO\nlaptop\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nat\tO\nleast\tO\neight\tO\nToshiba\tO\nlaptops\tO\n,\tO\nand\tO\nthey\tO\nhave\tO\nbeen\tO\noutstanding\tO\n,\tO\nincluding\tO\nthis\tO\none\tO\n.\tO\n\nI\tO\ncalled\tO\nback\tO\nto\tO\nensure\tO\nthat\tO\nreceived\tO\nit\tO\n,\tO\nthey\tO\nhad\tO\n.\tO\n\nthe\tO\nmanufacturer\tO\n's\tO\nwarranty\tB-aspectTerm\nonly\tO\ncovers\tO\nreplacement\tO\n/\tO\nrepair\tO\nof\tO\nparts\tO\n.\tO\n\nWhat\tO\nI\tO\n'd\tO\nlike\tO\nis\tO\nfor\tO\nthe\tO\nlaptop\tO\nto\tO\nrun\tB-aspectTerm\nwell\tO\nwithout\tO\nhaving\tO\nto\tO\npurchase\tO\nadditional\tO\nmemory\tB-aspectTerm\n.\tO\n\nIf\tO\nyou\tO\ncan\tO\nafford\tO\na\tO\nnew\tO\nlaptop\tO\n,\tO\nand\tO\nare\tO\nin\tO\nthe\tO\nmarket\tO\nfor\tO\none\tO\n,\tO\nof\tO\ncourse\tO\n,\tO\nthen\tO\ndefinitely\tO\ngo\tO\nfor\tO\nthis\tO\n.\tO\n\nGot\tO\nthe\tO\ncomputer\tO\nback\tO\na\tO\nmonth\tO\nlater\tO\nand\tO\nit\tO\nwas\tO\nstill\tO\nbroken\tO\nsent\tO\nit\tO\nout\tO\nagain\tO\nand\tO\nthey\tO\nrepaired\tO\nit\tO\n.\tO\n\nIt\tO\nworks\tB-aspectTerm\nexactly\tO\nlike\tO\nit\tO\ndid\tO\nthe\tO\nday\tO\nI\tO\ntook\tO\nit\tO\nout\tO\nof\tO\nthe\tO\nbox\tO\n.\tO\n\nNow\tO\n,\tO\nthe\tO\nnext\tO\nissue\tO\nI\tO\nhad\tO\nfreaked\tO\nme\tO\nout\tO\n.\tO\n\ni\tO\nlove\tO\nths\tO\nnotebook\tO\n.\tO\n\nIt\tO\nis\tO\nfast\tO\nbooting\tB-aspectTerm\nup\tI-aspectTerm\n,\tO\nshutting\tB-aspectTerm\ndown\tI-aspectTerm\n,\tO\nand\tO\nconnection\tB-aspectTerm\nwith\tI-aspectTerm\nthe\tI-aspectTerm\ninternet\tI-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\ngreat\tO\n.\tO\n\nThis\tO\nis\tO\nnot\tO\na\tO\nserious\tO\ngaming\tB-aspectTerm\nlaptop\tO\nor\tO\na\tO\nserious\tO\nmedia\tO\nmachine\tO\n;\tO\n\nEven\tO\nif\tO\nApple\tO\nreplaces\tO\nwhatever\tO\nneeds\tO\nreplacing\tO\nI\tO\nwonder\tO\nif\tO\n,\tO\nsince\tO\nI\tO\nseem\tO\nto\tO\nbe\tO\ndoubling\tO\nthe\tO\namount\tO\nof\tO\ntime\tO\nI\tO\nget\tO\nout\tO\nof\tO\nit\tO\neach\tO\ntime\tO\nit\tO\n's\tO\n\"\tO\nlike\tO\nnew\tO\n,\tO\n\"\tO\nI\tO\nmight\tO\nhave\tO\n8\tO\nmonths\tO\nnext\tO\ntime\tO\n.\tO\n\nI\tO\ngot\tO\nthis\tO\nlaptop\tO\non\tO\nBlack\tO\nFriday\tO\n.\tO\n\nThey\tO\nreplaced\tO\nmy\tO\nhard\tO\ndrive\tB-aspectTerm\nas\tI-aspectTerm\nwell\tO\nas\tO\nmy\tO\nmother\tO\nboard\tB-aspectTerm\n.\tI-aspectTerm\n\nI\tO\nfell\tO\nin\tO\nlove\tO\nwith\tO\nit\tO\n.\tO\n\nIt\tO\nwas\tO\njust\tO\none\tO\nproblem\tO\nafter\tO\nanother\tO\nfor\tO\nme\tO\n,\tO\nand\tO\nthat\tO\n's\tO\nreason\tO\nwe\tO\nhad\tO\nforked\tO\nout\tO\nso\tO\nmuch\tO\nmoney\tO\nwas\tO\nso\tO\nwe\tO\nwould\tO\nn't\tO\nhave\tO\nanything\tO\nto\tO\nworry\tO\nabout\tO\n.\tO\n\nThere\tO\nis\tO\nnothing\tO\nto\tO\ncomplain\tO\nabout\tO\nthe\tO\nsystem\tB-aspectTerm\n.\tO\n\nand\tO\nit\tO\ncomes\tO\nwith\tO\nthe\tO\nnew\tO\nOSX\tB-aspectTerm\nthat\tO\ncomes\tO\nwith\tO\nnew\tO\nfeatures\tB-aspectTerm\nthat\tO\nmakes\tO\nthe\tO\nuse\tB-aspectTerm\nmore\tO\neasy\tO\n.\tO\n\nMaybe\tO\nnot\tO\nthe\tO\ncutting\tO\nedge\tO\n(\tO\nSatellite\tO\nL455D\tO\n)\tO\nbut\tO\nit\tO\nis\tO\na\tO\nworkhorse\tO\n.\tO\n\nBut\tO\nthe\tO\nMacbook\tO\nis\tO\nthe\tO\nbest\tO\n!\tO\n\nNow\tO\nthe\tO\nscreen\tB-aspectTerm\nis\tO\ngoing\tO\ndarker\tO\n,\tO\ndarker\tO\n,\tO\ndarker\tO\n.\tO\n\nEITHER\tO\nTHE\tO\nCOMPUTER\tO\nIS\tO\nTOO\tO\nSLOW\tO\nTO\tO\nDETECT\tO\nTHE\tO\nKEYS\tB-aspectTerm\nTYPED\tO\n(\tO\nTHIS\tO\nIS\tO\nUNLIKELY\tO\nAS\tO\nI\tO\nAM\tO\nA\tO\nSLOW\tO\nTYPIST\tO\n)\tO\nOR\tO\nTHE\tO\nKEYBOARD\tB-aspectTerm\nSIMPLY\tO\nDOES\tO\nNOT\tO\nDETECT\tO\nTHE\tO\nKEYS\tB-aspectTerm\nBEING\tO\nTYPED\tO\n.\tO\n\nI\tO\ngot\tO\nthe\tO\nblack\tO\nMacBook\tO\ntwo\tO\nyears\tO\nago\tO\nand\tO\nhave\tO\nnever\tO\nregretted\tO\nit\tO\n.\tO\n\nAs\tO\na\tO\ngraphic\tO\narts\tO\na\tO\nretired\tO\ninstructor\tO\nI\tO\nstill\tO\nlove\tO\nto\tO\nplay\tO\nwith\tO\nthe\tO\ngraphic\tO\nwith\tO\nphotos\tO\nand\tO\nclip\tO\nart\tO\n.....\tO\n\nMy\tO\nwife\tO\nalso\tO\nhas\tO\nproblems\tO\nwith\tO\nher\tO\nAsus\tO\n-\tO\ndifferent\tO\nmodel\tO\n.\tO\n\nFeatures\tB-aspectTerm\nsuch\tO\nas\tO\nthe\tO\nDashboard\tB-aspectTerm\n(\tO\nallows\tO\nyou\tO\nto\tO\nview\tO\nfrequently\tO\nused\tO\ntools\tO\nlike\tO\na\tO\ncalculator\tO\n,\tO\nweather\tO\nforecast\tO\n,\tO\nmovie\tO\ntimes\tO\n,\tO\ncalendar\tO\n,\tO\ncomputer\tO\npost\tO\nits\tO\netc\tO\n.\tO\n\nThis\tO\ncomputer\tO\nis\tO\nthe\tO\nideal\tO\ncollege\tO\ncompanion\tO\n.\tO\n\nBoth\tO\ncomputers\tO\nstarted\tO\nacting\tO\nextremely\tO\nslow\tO\nwithin\tO\nthe\tO\nfirst\tO\nyear\tO\nof\tO\nowning\tO\nthem\tO\n.\tO\n\nThe\tO\nMacBook\tO\nPro\tO\nis\tO\nvery\tO\nsturdy\tO\nand\tO\nversatile\tO\n.\tO\n\nwhen\tO\ni\tO\ncalled\tO\nto\tO\nhave\tO\nanother\tO\none\tO\nshipped\tO\nor\tO\nto\tO\nget\tO\nmy\tO\nmoney\tO\nback\tO\nthey\tO\nsaid\tO\nthe\tO\nreturn\tB-aspectTerm\npolicy\tI-aspectTerm\nis\tO\n23\tO\ntwenty\tO\nthree\tO\ndays\tO\nfrom\tO\nthe\tO\ndate\tO\nof\tO\npurchase\tO\n.\tO\n\nBOUGHT\tO\nFROM\tO\nWAL\tO\n-\tO\nMART\tO\n,\tO\nI\tO\nBELIEVE\tO\nTHAT\tO\nTHIS\tO\nLAPTOP\tO\nWAS\tO\nA\tO\nREPAIRED\tO\nITEM\tO\n.\tO\n\nCould\tO\nnt\tO\nnot\tO\nuse\tO\nit\tO\n.\tO\n\nI\tO\nsent\tO\nit\tO\nback\tO\nand\tO\nfound\tO\nthis\tO\ntime\tO\nthat\tO\nthe\tO\nbattery\tO\nwas\tB-aspectTerm\nfaulty\tO\n,\tO\nso\tO\nI\tO\ngot\tO\na\tO\nnew\tO\none\tO\nand\tO\nsome\tO\nother\tO\nfixes\tO\nthey\tO\nfound\tO\n.\tO\n\nI\tO\nswear\tO\nthey\tO\ndesign\tO\nthese\tO\nthings\tO\nto\tO\ngo\tO\nto\tO\ncrap\tO\nafter\tO\na\tO\nyear\tO\nso\tO\nyou\tO\nare\tO\nstuck\tO\nand\tO\nhave\tO\nto\tO\nbuy\tO\na\tO\nnew\tO\none\tO\n.\tO\n\nGreat\tO\npick\tO\nfor\tO\nportability\tB-aspectTerm\nand\tO\naffordability\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nfast\tO\n,\tO\nit\tO\n's\tO\neasy\tO\neasy\tO\neasy\tO\nto\tO\nset\tB-aspectTerm\nup\tI-aspectTerm\n,\tO\neasy\tO\nto\tO\nhook\tB-aspectTerm\nto\tI-aspectTerm\nmy\tI-aspectTerm\nwireless\tI-aspectTerm\nnetwork\tI-aspectTerm\n.\tO\n\nI\tO\npreviously\tO\npurchased\tO\na\tO\n13\tO\n\"\tO\nmacbook\tO\n(\tO\nhad\tO\npro\tO\nspecs\tB-aspectTerm\nand\tO\nwas\tO\naluminum\tB-aspectTerm\nstyle\tI-aspectTerm\n)\tO\nwhich\tO\nhad\tO\na\tO\nnvidia\tB-aspectTerm\n9800\tI-aspectTerm\n(\tO\nIf\tO\nI\tO\nam\tO\nnot\tO\nmistaken\tO\n)\tO\nand\tO\nit\tO\nhad\tO\nmajor\tO\nheating\tO\nissues\tO\n.\tO\n\nThey\tO\ndid\tO\nn't\tO\neven\tO\ntry\tO\nto\tO\nassist\tO\nme\tO\nor\tO\neven\tO\noffer\tO\na\tO\nreplacement\tO\n.\tO\n\nWe\tO\nused\tO\nPC\tO\nproducts\tO\n-\tO\nit\tO\nseemed\tO\nsimpler\tO\nto\tO\ncontinue\tO\nwith\tO\nthe\tO\nsame\tO\nthing\tO\n.\tO\n\nThe\tO\npeople\tO\nthere\tO\njust\tO\nchanged\tO\nfor\tO\nme\tO\non\tO\nthe\tO\nspot\tO\nand\tO\nI\tO\ngot\tO\na\tO\nnew\tO\narm\tB-aspectTerm\npiece\tI-aspectTerm\nand\tO\nthey\tO\ndid\tO\nn't\tO\neven\tO\nrequest\tO\nfor\tO\na\tO\nreceipt\tO\n.\tO\n\nI\tO\nlove\tO\nmy\tO\nSamsung\tO\nTV\tO\nand\tO\nGalaxy\tO\nS\tO\nsmartphone\tO\n,\tO\nbut\tO\nthis\tO\nNetbook\tO\nwas\tO\na\tO\nvery\tO\npoor\tO\ncomputer\tO\n.\tO\n\nI\tO\nmade\tO\na\tO\nperfect\tO\ndecision\tO\nwhen\tO\nI\tO\nbought\tO\nthe\tO\nToshiba\tO\n!\tO\n\nI\tO\ntake\tO\nit\tO\neverywhere\tO\nwith\tO\nme\tO\nbecause\tO\nit\tO\n's\tO\nso\tO\neasy\tO\nto\tO\ncarry\tB-aspectTerm\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nis\tO\nthat\tO\nthe\tO\nbattery\tB-aspectTerm\nwo\tO\nn't\tO\nlast\tO\nmore\tO\nthan\tO\n1/2\tO\nan\tO\nhour\tO\n.\tO\n\nIt\tO\nstill\tO\nheats\tO\nup\tO\nlike\tO\nmad\tO\nand\tO\nI\tO\nam\tO\nunable\tO\nto\tO\nuse\tO\nit\tO\nwith\tO\nthe\tO\ncomputer\tO\ndirectly\tO\non\tO\nmy\tO\nlap\tO\nfor\tO\nmore\tO\nthan\tO\nfive\tO\nto\tO\nten\tO\nminutes\tO\nat\tO\na\tO\ntime\tO\n.\tO\n\nThe\tO\nfirst\tO\nfell\tO\napart\tO\nright\tO\nafter\tO\nthe\tO\n1-year\tB-aspectTerm\n-\tI-aspectTerm\nwarranty\tI-aspectTerm\n.\tO\n\nI\tO\nam\tO\nfinding\tO\nmy\tO\nway\tO\naround\tO\nthis\tO\nlaptop\tO\nbetter\tO\nthan\tO\nmy\tO\nlast\tO\none\tO\n.\tO\n\nThey\tO\ntold\tO\nme\tO\nit\tO\nwas\tO\nmy\tO\nloss\tO\neven\tO\nthough\tO\nit\tO\nwas\tO\nthe\tO\ncomputer\tO\n,\tO\nnot\tO\nwhat\tO\nI\tO\n've\tO\ndone\tO\n.\tO\n\nI\tO\nwould\tO\nHighly\tO\nrecommend\tO\nthis\tO\nMacBook\tO\n.\tO\n\nAbout\tO\n2\tO\nmonths\tO\nago\tO\ni\tO\nbought\tO\nthe\tO\n2011\tO\nmacbook\tO\npro\tO\n,\tO\nwhich\tO\nwas\tO\nan\tO\nupgrade\tO\nfrom\tO\nmy\tO\n2010\tO\nmacbook\tO\npro\tO\n.\tO\n\nLet\tO\n's\tO\njust\tO\nget\tO\nthis\tO\nout\tO\nof\tO\nthe\tO\nway\tO\n,\tO\nI\tO\nlove\tO\nApple\tO\n!\tO\n\nOh\tO\nand\tO\nit\tO\nhas\tO\nword\tB-aspectTerm\nand\tO\nstuff\tO\nbut\tO\nits\tO\na\tO\ntrial\tO\nverion\tO\nso\tO\nafter\tO\nabout\tO\na\tO\nmonth\tO\nor\tO\nso\tO\nwhen\tO\nyou\tO\ngo\tO\nto\tO\nopen\tO\nit\tO\nit\tO\nasks\tO\nfor\tO\na\tO\nproduct\tO\nkey\tO\nwhich\tO\ndid\tO\nnt\tO\ncome\tO\nwith\tO\nthe\tO\ncomputer\tO\nand\tO\neven\tO\nafter\tO\nclicking\tO\ncancel\tO\nit\tO\nwo\tO\nnt\tO\nlet\tO\nyou\tO\nuse\tO\nit\tO\nat\tO\nall\tO\nI\tO\nuse\tO\nthe\tO\nold\tO\nword\tB-aspectTerm\nprocesser\tI-aspectTerm\nwhich\tO\nworks\tO\ngood\tO\n.\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\nhas\tO\na\tO\nwonderful\tO\nnature\tO\nfeel\tO\n.\tO\n\nThey\tO\nwent\tO\nthrough\tO\nasking\tO\nme\tO\nopen\tO\nup\tO\nvarious\tO\ncomponents\tO\n,\tO\ntaking\tO\nbattery\tB-aspectTerm\nout\tO\n,\tO\nhard\tB-aspectTerm\ndisk\tI-aspectTerm\napart\tO\n,\tO\nand\tO\nafter\tO\n2\tO\nhours\tO\non\tO\nphone\tO\ncould\tO\nnot\tO\nfix\tO\nit\tO\n.\tO\n\n*\tO\n4\tO\nweeks\tO\nafter\tO\ngiving\tO\nthe\tO\ncomputer\tO\nfor\tO\nrepair*-Annoyed\tO\nat\tO\nMacHouse\tO\nAmsterdam\tO\n,\tO\ndecided\tO\nto\tO\nsend\tO\ncomplaint\tO\nemail\tO\nto\tO\nApple\tO\n.\tO\n\nWhile\tO\nthere\tO\nare\tO\noccasions\tO\nthat\tO\nmy\tO\ncomputer\tO\nwill\tO\nfreeze\tO\nor\tO\nwill\tO\nneed\tO\nto\tO\nbe\tO\nmanually\tO\nshut\tO\ndown\tO\n,\tO\nthis\tO\noccurs\tO\nfar\tO\nless\tO\nfrequently\tO\nthan\tO\non\tO\nPC\tO\ncomputers\tO\nand\tO\nlaptops\tO\nthat\tO\nI\tO\n've\tO\nused\tO\n.\tO\n\nBought\tO\nwith\tO\na\tO\ncredit\tO\ncard\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\ndoes\tO\nn't\tO\nlast\tO\nlong\tO\nbut\tO\nI\tO\n'm\tO\nsure\tO\nan\tO\nupgrade\tO\nbattery\tB-aspectTerm\nwould\tO\nsolve\tO\nthat\tO\nproblem\tO\n.\tO\n\nI\tO\nwas\tO\nlooking\tO\ntoo\tO\nclosely\tO\nat\tO\nthe\tO\nother\tO\nperformance\tB-aspectTerm\nspecs\tI-aspectTerm\nand\tO\nwhile\tO\ncomparing\tO\n,\tO\nI\tO\ntook\tO\nit\tO\nfor\tO\ngranted\tO\nthat\tO\nthese\tO\nfeatures\tB-aspectTerm\nwere\tO\nstandard\tO\n.\tO\n\nI\tO\ndid\tO\na\tO\nlot\tO\nof\tO\nresearch\tO\nand\tO\nended\tO\nup\tO\nthinking\tO\nthis\tO\nToshiba\tO\nwas\tO\nthe\tO\nbest\tO\none\tO\nfor\tO\nme\tO\n.\tO\n\n\"\tO\nI\tO\n've\tO\nhad\tO\nit\tO\nnow\tO\nabout\tO\n2\tO\nmonths\tO\nand\tO\nabsolutely\tO\nLOVE\tO\nIT\tO\n.\tO\n\nI\tO\nhave\tO\nno\tO\nidea\tO\nhow\tO\nthis\tO\ncould\tO\nhave\tO\neven\tO\ngotten\tO\npast\tO\nquality\tB-aspectTerm\ncontrol\tI-aspectTerm\nduring\tO\nproduction\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nlast\tO\nweek\tO\n,\tO\nand\tO\nthe\tO\nvery\tO\nnext\tO\nday\tO\nhad\tO\nto\tO\nreturn\tO\nit\tO\nbecause\tO\nit\tO\nover\tO\nheated\tO\nand\tO\nthe\tO\ntouch\tB-aspectTerm\n-\tI-aspectTerm\nmouse\tI-aspectTerm\nstopped\tO\nresponding\tO\n.\tO\n\nI\tO\nam\tO\nso\tO\nhappy\tO\nto\tO\nhave\tO\npurchased\tO\nthis\tO\ncomputer\tO\n.\tO\n\nOh\tO\nyea\tO\n,\tO\nhas\tO\nno\tO\nnumeric\tB-aspectTerm\npad\tI-aspectTerm\non\tO\nthe\tO\nside\tO\n.\tO\n\nThe\tO\ncover\tB-aspectTerm\nfor\tI-aspectTerm\nthe\tI-aspectTerm\nDVD\tI-aspectTerm\ndrive\tI-aspectTerm\nsoon\tO\ncame\tO\noff\tO\n,\tO\ntoo\tO\n--\tO\na\tO\nmark\tO\nof\tO\npoor\tO\nconstruction\tB-aspectTerm\nquality\tI-aspectTerm\n.\tO\n\nI\tO\nreturned\tO\nthe\tO\n2nd\tO\nlaptop\tO\nfor\tO\na\tO\nfull\tO\nrefund\tO\n.\tO\n\nreally\tO\nno\tO\nproblems\tO\nwith\tO\nthe\tO\nhand\tO\nme\tO\ndown\tO\ncomputers\tO\nI\tO\nreceived\tO\nfrom\tO\nmy\tO\nchildren\tO\n.\tO\n\nI\tO\ndid\tO\nnot\tO\ntake\tO\nthe\tO\nclass\tO\nand\tO\nwish\tO\nthat\tO\nI\tO\nwould\tO\nhave\tO\n.\tO\n\nIt\tO\nwould\tO\nbe\tO\na\tO\nload\tO\non\tO\nlong\tO\ntrips\tO\nwhere\tO\na\tO\nlot\tO\nof\tO\nwalking\tO\nis\tO\nrequired\tO\n.\tO\n\nBut\tO\nthe\tO\narm\tB-aspectTerm\nvelcro\tI-aspectTerm\nis\tO\ntorn\tO\nafter\tO\none\tO\nuse\tO\n.\tO\n\nNot\tO\ngood\tO\nfor\tO\na\tO\nperson\tO\nwho\tO\ngets\tO\nonline\tO\ndaily\tO\n.\tO\n\nThe\tO\nlaptop\tO\nwas\tO\nreturned\tO\nbut\tO\naudio\tO\nissue\tO\nwas\tO\nnot\tO\nfixed\tO\n.\tO\n\nI\tO\nca\tO\nn't\tO\neven\tO\nremember\tO\nhow\tO\nI\tO\nfinally\tO\ngot\tO\nit\tO\ntaken\tO\ncare\tO\nof\tO\n,\tO\nbut\tO\nI\tO\nwas\tO\ndone\tO\nwith\tO\nSony\tO\nafter\tO\nthat\tO\n!\tO\n\nSo\tO\nit\tO\nwas\tO\nonly\tO\nabout\tO\n2\tO\nweeks\tO\nago\tO\n.\tO\n\nI\tO\njust\tO\nlove\tO\nthis\tO\nlap\tO\ntop\tO\n,\tO\nI\tO\njust\tO\nwish\tO\nit\tO\nwere\tO\nall\tO\nsilver\tO\nor\tO\nthey\tO\nhad\tO\nall\tO\nblack\tO\n.\tO\n\nThe\tO\nsoftware\tB-aspectTerm\nis\tO\namazing\tO\n.\tO\n\nWe\tO\ncarry\tO\nthe\tO\nnetbook\tO\naround\tO\nhere\tO\nand\tO\nthere\tO\n,\tO\nhence\tO\nit\tO\n's\tO\nkinda\tO\nof\tO\nirritating\tO\nwhen\tO\nthe\tO\nLCD\tB-aspectTerm\njust\tO\n\"\tO\nslide\tO\n\"\tO\ndownwards\tO\n.\tO\n\nThere\tO\nis\tO\nnothing\tO\nbetter\tO\n.\tO\n\nI\tO\nnow\tO\nown\tO\nanother\tO\nHewlitt\tO\nPackard\tO\n.\tO\n\nThe\tO\n2\tB-aspectTerm\nGB\tI-aspectTerm\nof\tI-aspectTerm\nRAM\tI-aspectTerm\nis\tO\nplenty\tO\n,\tO\nable\tO\nto\tO\nrun\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nand\tO\nat\tO\nleast\tO\n2\tO\nor\tO\n3\tO\nother\tO\nprograms\tB-aspectTerm\nwith\tO\nnext\tO\nto\tO\nno\tO\nslowdown\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\namazing\tO\n,\tO\nthe\tO\nversitility\tB-aspectTerm\nis\tO\noutstanding\tO\n.\tO\n\nIt\tO\nis\tO\nknown\tO\nas\tO\nSafari\tB-aspectTerm\n,\tO\nand\tO\nif\tO\nyou\tO\nare\tO\ndoing\tO\nany\tO\nwebsite\tO\nwork\tO\n,\tO\nyou\tO\nshould\tO\nknow\tO\nthat\tO\nmany\tO\nhosting\tO\ncompanies\tO\ndo\tO\nnot\tO\nsupport\tO\nit\tO\n.\tO\n\nVista\tB-aspectTerm\nis\tO\na\tO\nnightmare\tO\n.\tO\n\ni\tO\nspent\tO\neight\tO\nhundred\tO\ndollars\tO\nfrom\tO\na\tO\ngiant\tO\npaper\tO\nweight\tO\nthat\tO\nlooks\tO\ngood\tO\non\tO\na\tO\nbus\tO\n.\tO\n\nI\tO\nhave\tO\nused\tO\na\tO\ncouple\tO\nof\tO\nothers\tO\non\tO\nthe\tO\njob\tO\nas\tO\nwell\tO\n.\tO\n\nThe\tO\nprogram\tB-aspectTerm\ncame\tO\nwith\tO\nthe\tO\ncomputer\tO\nand\tO\nworks\tO\nbeautifully\tO\n.\tO\n\nPosted\tO\nNov\tO\n8\tO\n,\tO\n2010\tO\n-\tO\nTwo\tO\nweeks\tO\nago\tO\nI\tO\nbought\tO\nthis\tO\nnotebook\tO\n.\tO\n\nAcer\tO\nwo\tO\nn't\tO\nreplace\tO\nthe\tO\nlaptop\tO\n.\tO\n\nI\tO\nam\tO\nalso\tO\nupset\tO\nwith\tO\nCR\tO\nfor\tO\ngiving\tO\na\tO\ngood\tO\nrating\tO\n.\tO\n\nthe\tO\nhinge\tB-aspectTerm\ndesign\tI-aspectTerm\nforced\tO\nyou\tO\nto\tO\nplace\tO\nvarious\tO\nconnections\tO\nall\tO\naround\tO\nthe\tO\ncomputer\tO\n,\tO\nleft\tO\nright\tO\nand\tO\nfront\tO\n.\tO\n\nI\tO\nhave\tO\nowned\tO\nmacbook\tO\npros\tO\nsince\tO\n2005\tO\nand\tO\nthis\tO\nis\tO\nthe\tO\nbest\tO\nyet\tO\n!\tO\n\nI\tO\nwas\tO\nloving\tO\nthis\tO\nNetbook\tO\nbecause\tO\nit\tO\nhad\tO\nan\tO\namazing\tO\nscreen\tB-aspectTerm\nand\tO\ndisplay\tB-aspectTerm\nand\tO\nwas\tO\nsmall\tO\nand\tO\nlight\tO\n,\tO\nbut\tO\nafter\tO\n1\tO\nweek\tO\nit\tO\nstopped\tO\nopenning\tO\nweb\tO\npages\tO\nfor\tO\nme\tO\n(\tO\neven\tO\nafter\tO\ninstalling\tO\nnew\tO\nbrowsers\tB-aspectTerm\n)\tO\nthen\tO\neventually\tO\nit\tO\njust\tO\nstarted\tO\ngiving\tO\nme\tO\na\tO\nblue\tO\nscreen\tO\nand\tO\ncrashing\tO\neverytime\tO\nI\tO\nbooted\tO\nit\tO\n.\tO\n\nNow\tO\nI\tO\ncould\tO\nget\tO\nmyself\tO\na\tO\ncheap\tO\ncomputer\tO\n,\tO\nthat\tO\nwill\tO\nprobably\tO\nwork\tO\na\tO\nwhole\tO\nlot\tO\nbetter\tO\n!\tO\n\nI\tO\nwould\tO\ndefinitely\tO\nnot\tO\ngo\tO\nback\tO\nto\tO\nusing\tO\na\tO\nPC\tO\nafter\tO\nusing\tO\nthe\tO\nmac\tO\n.\tO\n\nThe\tO\nSo\tO\ncalled\tO\nlaptop\tO\nRuns\tB-aspectTerm\nto\tO\nSlow\tO\nand\tO\nI\tO\nhate\tO\nit\tO\n!\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\nlaptop\tO\nI\tO\n've\tO\nowned\tO\n,\tO\nalthougth\tO\nI\tO\nused\tO\nseveral\tO\nat\tO\nmy\tO\nprevious\tO\njob\tO\n.\tO\n\nThose\tO\nmoments\tO\nin\tO\nthime\tO\nwhere\tO\nyou\tO\nwant\tO\nto\tO\nthrow\tO\nsomething\tO\nagainst\tO\nthe\tO\nwall\tO\n?\tO\nYeah\tO\n,\tO\nI\tO\nwanted\tO\nto\tO\nthrow\tO\nthat\tO\nlap\tO\ntop\tO\nout\tO\nthe\tO\nwindow\tO\nand\tO\nlight\tO\nit\tO\non\tO\nfire\tO\n.\tO\n\nCharger\tB-aspectTerm\nseems\tO\nlarge\tO\nfor\tO\nthis\tO\nclass\tO\nof\tO\ncomputer\tO\n.\tO\n\nI\tO\ndo\tO\nn't\tO\nreally\tO\nhave\tO\na\tO\ncomplaint\tO\n.\tO\n\nI\tO\n'm\tO\npretty\tO\nsure\tO\nit\tO\n's\tO\nnot\tO\nnewegg\tO\n's\tO\nfault\tO\nbut\tO\nwhen\tO\nyou\tO\nturn\tO\non\tO\na\tO\ncomputer\tO\nyou\tO\njust\tO\nbought\tO\nyou\tO\nwant\tO\nit\tO\nto\tO\nat\tO\nleast\tO\nget\tO\nto\tO\ndesktop\tO\n.\tO\n\nBest\tO\nBuy\tO\nended\tO\nup\tO\njunking\tO\nthe\tO\ncomputer\tO\nand\tO\ngiving\tO\nme\tO\na\tO\nreplacement\tO\ncomputer\tO\n.\tO\n\nI\tO\ndislike\tO\nthe\tO\nquality\tO\nand\tO\nthe\tO\nplacement\tO\nof\tO\nthe\tO\nspeakers\tB-aspectTerm\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\ngraphics\tI-aspectTerm\nand\tO\nclarity\tB-aspectTerm\n,\tO\nand\tO\nsharpness\tB-aspectTerm\nare\tO\ngreat\tO\n.\tO\n\nIf\tO\nI\tO\nhave\tO\na\tO\nproblem\tO\nwith\tO\nany\tO\nof\tO\nmy\tO\napple\tO\nitems\tO\nI\tO\nmake\tO\nan\tO\nappointment\tO\nat\tO\none\tO\nof\tO\nmy\tO\nlocal\tO\nstores\tO\nand\tO\nthey\tO\nwork\tO\non\tO\ncorrecting\tO\nit\tO\nright\tO\nthere\tO\n.\tO\n\nSo\tO\nI\tO\ncalled\tO\ncustomer\tB-aspectTerm\nsupport\tI-aspectTerm\n(\tO\nwhich\tO\nis\tO\ngood\tO\ntoo\tO\n)\tO\nand\tO\nthey\tO\nwent\tO\nthrough\tO\nit\tO\nand\tO\nit\tO\nis\tO\njust\tO\na\tO\nsafety\tB-aspectTerm\nfeature\tI-aspectTerm\nand\tO\nit\tO\ndoes\tO\nnot\tO\naffect\tO\nperformance\tB-aspectTerm\nat\tO\nall\tO\n,\tO\nI\tO\njust\tO\nchose\tO\nto\tO\nhide\tO\nthe\tO\nmessage\tO\n.\tO\n\nI\tO\nclaim\tO\nthat\tO\nthis\tO\nhas\tO\nno\tO\nvalue\tO\nto\tO\nme\tO\n,\tO\nthe\tO\nlaptop\tO\nwas\tO\nnew\tO\nanyway\tO\n.\tO\n\nEnough\tO\nsaid\tO\n.\tO\n\nNot\tO\nworking\tO\n=\tO\nbad\tO\n\ni\tO\nwould\tO\nreally\tO\nrecommend\tO\nto\tO\nany\tO\nperson\tO\nout\tO\nthere\tO\nto\tO\nget\tO\nthis\tO\nlaptop\tO\ncause\tO\nits\tO\nreally\tO\nworth\tO\nit\tO\n.\tO\n\nOtherwise\tO\nthis\tO\nlittle\tO\nnotebook\tO\nhas\tO\nmet\tO\nall\tO\nmy\tO\nexpectations\tO\n.\tO\n\nMy\tO\nson\tO\nsaid\tO\nit\tO\npopped\tO\nup\tO\nand\tO\nhe\tO\nclicked\tO\nupdate\tO\n.\tO\n\nI\tO\nlost\tO\ntwo\tO\nitems\tO\nI\tO\nwas\tO\nworking\tO\non\tO\nuntil\tO\nI\tO\nfigured\tO\nout\tO\nwhat\tO\nwas\tO\nhappening\tO\n.\tO\n\nThe\tO\nunibody\tB-aspectTerm\ndesign\tI-aspectTerm\nis\tO\nedgy\tO\nand\tO\ndurable\tO\n.\tO\n\nSTOPPED\tO\nBOOTING\tB-aspectTerm\nUP\tI-aspectTerm\nless\tO\nthan\tO\na\tO\nweek\tO\nafter\tO\nmy\tO\none\tB-aspectTerm\n-\tI-aspectTerm\nyear\tI-aspectTerm\nwarranty\tI-aspectTerm\nwas\tO\nup\tO\n.\tO\n\nBut\tO\n,\tO\nfor\tO\nthe\tO\ncost\tB-aspectTerm\nthis\tO\nis\tO\na\tO\nwinner\tO\n.\tO\n\nLet\tO\nme\tO\ntell\tO\nyou\tO\n,\tO\nthis\tO\nmachine\tO\nis\tO\ngreat\tO\n.\tO\n\nI\tO\nhave\tO\nused\tO\na\tO\ncomputer\tO\nat\tO\nwork\tO\nbut\tO\nhaving\tO\nyour\tO\nown\tO\npersonal\tO\nlaptop\tO\nis\tO\nAWSOME\tO\n!\tO\n\nLater\tO\nit\tO\nheld\tO\nzero\tO\ncharge\tB-aspectTerm\nand\tO\nits\tO\nreplacement\tO\nworked\tO\nfor\tO\nless\tO\nthan\tO\nthree\tO\nmonths\tO\n.\tO\n\nThe\tO\nsecond\tO\nissue\tO\nI\tO\nhad\tO\nwith\tO\nit\tO\noccured\tO\na\tO\nmonth\tO\nlater\tO\nand\tO\nit\tO\nkept\tO\noverheating\tO\n,\tO\neven\tO\nif\tO\non\tO\nfor\tO\nless\tO\nthan\tO\nan\tO\nhour\tO\n!\tO\n\nAlso\tO\n,\tO\nthe\tO\nbattery\tO\ndoes\tB-aspectTerm\nnot\tO\nlast\tO\nvery\tO\nlong\tO\nat\tO\nall\tO\n.\tO\n\nGood\tO\nluck\tO\nwith\tO\nyour\tO\npurchase\tO\noptions\tO\n.\tO\n\nBuy\tO\nthis\tO\nif\tO\nyou\tO\nlike\tO\nbeing\tO\ntortured\tO\n,\tO\nteased\tO\n,\tO\nfrustrated\tO\nand\tO\nwasting\tO\ntwice\tO\nas\tO\nmuch\tO\ntime\tO\nas\tO\nyou\tO\nspent\tO\nusing\tO\nyour\tO\nold\tO\nMac\tO\n.\tO\n\nVery\tO\ndisappointed\tO\n!\tO\n\nThey\tO\nare\tO\nasking\tO\nme\tO\nto\tO\nship\tO\nthe\tO\nunit\tO\nback\tO\nto\tO\nfix\tO\nit\tO\nat\tO\ntheir\tO\nsite\tO\n.\tO\n\nI\tO\nbought\tO\nit\tO\nfrom\tO\nHSN\tO\nbecause\tO\nit\tO\nwas\tO\n\"\tO\nbundled\tO\n\"\tO\nwith\tO\nextra\tO\nsoftware\tB-aspectTerm\n,\tO\nbut\tO\nas\tO\nit\tO\nturns\tO\nout\tO\n,\tO\nthat\tO\nsoftware\tB-aspectTerm\njust\tO\ncrashes\tO\nit\tO\nmore\tO\noften\tO\n.....\tO\n\nI\tO\nlooked\tO\naround\tO\nand\tO\nbased\tO\noff\tO\nmy\tO\nprice\tB-aspectTerm\n/\tO\nfeatures\tB-aspectTerm\ncomparison\tO\nfrom\tO\na\tO\nbrand\tO\nI\tO\ntrusted\tO\nI\tO\nlanded\tO\nhere\tO\n.\tO\n\nI\tO\nconstantly\tO\nhad\tO\nto\tO\nsend\tO\nmy\tO\nlaptop\tO\nin\tO\nfor\tO\nservices\tO\nevery\tB-aspectTerm\n3\tO\nmonths\tO\nand\tO\nit\tO\nalways\tO\nseems\tO\nto\tO\nbe\tO\nthe\tO\nsame\tO\nproblem\tO\nthat\tO\nthey\tO\nsaid\tO\nthey\tO\nhad\tO\nalready\tO\nfixed\tO\n.\tO\n\nStrong\tO\nperformance\tB-aspectTerm\nin\tO\nthis\tO\ndevice\tO\nmakes\tO\nuse\tB-aspectTerm\nof\tO\nfun\tO\nand\tO\na\tO\nstrong\tO\nsense\tO\nof\tO\nthe\tO\nera\tO\nof\tO\nspeed\tB-aspectTerm\nThis\tO\ndevice\tO\nserves\tO\nall\tO\nmodern\tO\nrequirements\tO\nis\tO\na\tO\nvery\tO\nstrong\tO\ngame\tO\nand\tO\nis\tO\nvery\tO\nuseful\tO\nfor\tO\ndesigners\tO\n.\tO\n\nUnless\tO\nyou\tO\nneed\tO\nthe\tO\nBluetooth\tB-aspectTerm\n3\tI-aspectTerm\n.\tO\n\nI\tO\nwas\tO\nsorly\tO\ndisapointed\tO\nto\tO\ndiscover\tO\nthat\tO\nHP\tO\n(\tO\nwhat\tO\nI\tO\nthought\tO\nwas\tO\na\tO\nreputable\tO\ncompany\tO\n)\tO\nwould\tO\nn't\tO\nhonor\tO\nthe\tO\nwarrenty\tB-aspectTerm\nwhen\tO\nthe\tO\nfan\tB-aspectTerm\nblade\tI-aspectTerm\nfell\tO\napart\tO\n.\tO\n\nThat\tO\nis\tO\npretty\tO\nsad\tO\nwhen\tO\nthey\tO\nname\tO\nthem\tO\nspecifically\tO\n.\tO\n\nMore\tO\ntimes\tO\nthat\tO\nnot\tO\nthe\tO\nscreen\tO\npops\tO\nup\tO\nsaying\tO\nI\tO\nhave\tO\na\tO\nbad\tO\ninternet\tB-aspectTerm\nconnection\tI-aspectTerm\n,\tO\nor\tO\nthe\tO\npage\tO\nca\tO\nn't\tO\nbe\tO\ndisplayed\tO\n.\tO\n\nNo\tO\nviruses\tO\n.\tO\n\nIt\tO\nis\tO\neverything\tO\nthat\tO\nI\tO\nwould\tO\nwant\tO\nin\tO\na\tO\ncomputer\tO\n.\tO\n\nDo\tO\nyourself\tO\na\tO\nfavor\tO\nand\tO\ninvest\tO\nin\tO\na\tO\nfew\tO\nexternal\tB-aspectTerm\nharddrives\tI-aspectTerm\nif\tO\nyou\tO\nare\tO\nplanning\tO\non\tO\npurchasing\tO\nthis\tO\nlaptop\tO\n.\tO\n\nHowever\tO\n,\tO\nIf\tO\nI\tO\nsound\tO\nenthusiastic\tO\nabout\tO\nthis\tO\n,\tO\nI\tO\nam\tO\n!\tO\n\nYou\tO\nwill\tO\nfall\tO\nin\tO\nlove\tO\nwith\tO\nit\tO\nin\tO\nno\tO\ntime\tO\n.\tO\n\ni\tO\ngive\tO\nthis\tO\nlaptop\tO\na\tO\nfive\tO\nstar\tO\nreview\tO\ni\tO\nlove\tO\nit\tO\nand\tO\nit\tO\nhas\tO\ndone\tO\nchams\tO\nfor\tO\nme\tO\n.\tO\n\nThey\tO\nremoved\tO\nthem\tO\nand\tO\nreturned\tO\nthe\tO\ncomputer\tO\nto\tO\nme\tO\n.\tO\n\nI\tO\ndo\tO\nn't\tO\nunderstand\tO\nwhy\tO\nonly\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nStarter\tI-aspectTerm\nis\tO\nincluded\tO\n.\tO\n\nOn\tO\n3\tO\nJuly\tO\n2004\tO\n,\tO\nI\tO\npurcased\tO\nthis\tO\nmodel\tO\nat\tO\nBest\tO\nBuy\tO\nfor\tO\nabout\tO\n$\tO\n150\tO\n\nI\tO\nwent\tO\nwith\tO\nhim\tO\nand\tO\nwe\tO\npicked\tO\nthis\tO\none\tO\n.\tO\n\nWhile\tO\nmost\tO\npeople\tO\nsay\tO\nthat\tO\nPCs\tO\nhold\tO\nfunctionality\tB-aspectTerm\nand\tO\nvalue\tB-aspectTerm\nand\tO\nMacs\tO\nare\tO\njust\tO\npretty\tO\nto\tO\nlook\tB-aspectTerm\nat\tO\n,\tO\nI\tO\nthink\tO\nthere\tO\n's\tO\nsomething\tO\nto\tO\nbe\tO\nsaid\tO\nabout\tO\nthe\tO\nsimplicity\tB-aspectTerm\nof\tO\nMacs\tO\n.\tO\n\nThis\tO\nis\tO\nmy\tO\nsecond\tO\nMACBOOK\tO\nPRO\tO\nand\tO\nit\tO\n's\tO\nbetter\tO\nthan\tO\never\tO\n.\tO\n\nMy\tO\nmacbook\tO\nis\tO\nso\tO\nmuch\tO\nbetter\tO\nlooking\tB-aspectTerm\nand\tO\nso\tO\nthin\tO\n!\tO\n\nThe\tO\nnotebook\tO\nwould\tO\nnot\tO\nturn\tO\nback\tO\non\tO\nagain\tO\n.\tO\n\nThe\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\nis\tO\nwonderful\tO\n.\tO\n\nThis\tO\nsystem\tO\ncame\tO\nloaded\tO\nwith\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nStarter\tI-aspectTerm\n.\tO\n\n-When\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwent\tO\nto\tO\n4\tO\nhours\tO\nor\tO\nless\tO\n,\tO\ntook\tO\nit\tO\nto\tO\nthe\tO\nMacHouse\tO\nAmsterdam\tO\nfor\tO\nrepair\tO\n(\tO\n26th\tO\nof\tO\nAugust\tO\n)\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\ngets\tO\nso\tO\nHOT\tO\nit\tO\nis\tO\nscary\tO\n.\tO\n\nBest\tO\nthing\tO\nis\tO\nI\tO\ncan\tO\nuse\tO\nexisting\tO\n32\tO\nbit\tO\nold\tO\nprograms\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nso\tO\nnice\tO\nto\tO\nlook\tB-aspectTerm\nat\tO\nand\tO\nthe\tO\nkeys\tB-aspectTerm\nare\tO\neasy\tO\nto\tO\ntype\tO\nwith\tO\n.\tO\n\nThe\tO\napple\tO\nmacbook\tO\npro\tO\nnothing\tO\nto\tO\nsay\tO\nbutprofessionally\tO\ngreat\tO\nand\tO\noutstanding\tO\n.\tO\n\nIt\tO\n's\tO\nalso\tO\nvery\tO\nenergy\tO\nefficient\tO\n,\tO\nrunning\tO\non\tO\na\tO\nquarter\tO\nof\tO\nthe\tO\npower\tO\nit\tO\ntakes\tO\nto\tO\nrun\tO\na\tO\n60\tO\nWatt\tO\nlightbulb\tO\n.\tO\n\nI\tO\nam\tO\nforever\tO\nchanged\tO\nand\tO\nwill\tO\nno\tO\nlonger\tO\nbuy\tO\na\tO\nWindows\tB-aspectTerm\nbased\tO\nmachine\tO\nfor\tO\npersonal\tO\nuse\tO\n.\tO\n\nMom\tO\n,\tO\nDad\tO\n,\tO\nBrother\tO\n,\tO\nsister\tO\n,\tO\nYou\tO\nname\tO\nit\tO\n!\tO\n\nbut\tO\nit\tO\ncame\tO\nback\tO\nin\tO\neven\tO\nworse\tO\nshape\tO\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\nwould\tO\nchange\tO\nabout\tO\nit\tO\nis\tO\nthe\tO\nmouse\tB-aspectTerm\nkeys\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nabsolutely\tO\nhorrible\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\ndespite\tO\nall\tO\nits\tO\nso\tO\ncalled\tO\nadvanced\tO\nfeatures\tB-aspectTerm\n.\tO\n\nBefore\tO\n,\tO\nI\tO\nreloaded\tO\nwith\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nUltimate\tI-aspectTerm\nand\tO\nused\tO\nonly\tO\nthe\tO\ndownloaded\tO\ndrivers\tB-aspectTerm\nfrom\tO\nAcer\tO\n's\tO\nsite\tO\n.\tO\n\nI\tO\nhave\tO\nto\tO\nkeep\tO\nturning\tO\nit\tO\nuntil\tO\nit\tO\ndecides\tO\nto\tO\nlower\tO\nand\tO\nthere\tO\nis\tO\nno\tO\nmute\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nstill\tO\nbeautiful\tO\nand\tO\nhas\tO\nbetter\tO\ncolor\tB-aspectTerm\nreproduction\tI-aspectTerm\nthan\tO\nI\tO\ncould\tO\never\tO\nexpect\tO\nfrom\tO\na\tO\nnotebook\tO\n.\tO\n\nAfter\tO\nthat\tO\nI\tO\nturned\tO\nto\tO\nemail\tO\nin\tO\nmy\tO\nnext\tO\nvain\tO\nhelp\tO\nto\tO\nget\tO\nthem\tO\nto\tO\nacknowledge\tO\nthat\tO\nthe\tO\nwarranty\tB-aspectTerm\nwas\tO\nstill\tO\nvalid\tO\n.\tO\n\nSo\tO\nfar\tO\n,\tO\na\tO\ngreat\tO\nproduct\tO\n.\tO\n\nHe\tO\nloves\tO\nit\tO\nand\tO\nit\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nwell\tO\nthe\tO\nschools\tO\nstart\tO\nteaching\tO\nthe\tO\nkids\tO\nearly\tO\nabout\tO\ncomputers\tO\nso\tO\nit\tO\nwas\tO\neasy\tO\nfor\tO\nhim\tO\nto\tO\nget\tO\nstarted\tO\n.\tO\n\nu\tO\ncan\tO\ndo\tO\nwhat\tO\nu\tO\nwant\tO\nin\tO\njust\tO\nfew\tO\nseconds\tO\n,\tO\neven\tO\nto\tO\nstart\tB-aspectTerm\nup\tI-aspectTerm\nyour\tO\ncomputer\tO\ntakes\tO\nfew\tO\nseconds\tO\n.\tO\n\nIt\tO\n's\tO\nthe\tO\nmost\tO\nwonderful\tO\nthing\tO\nin\tO\nthe\tO\nentire\tO\nworld\tO\n.\tO\n\nSo\tO\nI\tO\n'd\tO\npop\tO\nthem\tO\noff\tO\nto\tO\nsee\tO\nwhat\tO\nthe\tO\nproblem\tO\nwas\tO\n,\tO\nwell\tO\nguess\tO\nwhat\tO\n?\tO\nThe\tO\ndarn\tO\nthing\tO\nwould\tO\nn't\tO\ngo\tO\nback\tO\non\tO\n.\tO\n\nAlso\tO\n,\tO\nmacbooks\tO\ncome\tO\nwith\tO\nmuch\tO\nmore\tO\nfeatures\tB-aspectTerm\nwhich\tO\nare\tO\nso\tO\ncool\tO\n!\tO\n\nThey\tO\nsent\tO\nout\tO\na\tO\nSony\tB-aspectTerm\n'\tI-aspectTerm\nCertified\tI-aspectTerm\n'\tI-aspectTerm\ntechnician\tI-aspectTerm\n.\tO\n\nThey\tO\nhave\tO\ndeveloped\tO\nexcellent\tO\nproprietary\tB-aspectTerm\nsoftware\tI-aspectTerm\nfor\tO\nediting\tO\nvideo\tO\nand\tO\npictures\tO\nand\tO\nI\tO\n'm\tO\nlooking\tO\nforward\tO\nto\tO\nutilizing\tO\nthese\tO\ntools\tO\non\tO\nthe\tO\nregular\tO\n.\tO\n\nGetting\tO\nthe\tO\nApple\tB-aspectTerm\nCare\tI-aspectTerm\nplan\tI-aspectTerm\nis\tO\na\tO\nmust\tO\n.\tO\n\nI\tO\n've\tO\nsaved\tO\na\tO\nlot\tO\nof\tO\ntime\tO\nand\tO\nheadaches\tO\nso\tO\nfar\tO\n,\tO\nusing\tO\nmy\tO\nnew\tO\nMacBook\tO\nPro\tO\n.\tO\n\noverall\tO\ni\tO\nwould\tO\nrecomend\tO\nthis\tO\nto\tO\nanybody\tO\nand\tO\ntell\tO\nthem\tO\nthat\tO\nif\tO\nthey\tO\nwant\tO\nto\tO\nburn\tO\ntheir\tO\nmusic\tO\nor\tO\nplay\tO\nthere\tO\nvideo\tB-aspectTerm\ngames\tI-aspectTerm\nto\tO\nbuy\tO\nthe\tO\ncd\tB-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\n-Apple\tO\noffers\tO\nto\tO\nsend\tO\nreplacement\tO\nand\tO\nafter\tO\n10\tO\ndays\tO\nI\tO\nsend\tO\nthem\tO\nthe\tO\nold\tO\ncomputer\tO\n.\tO\n\nSo\tO\nfar\tO\n,\tO\nI\tO\nhave\tO\nno\tO\ncomplaints\tO\n.\tO\n\nHis\tO\nwas\tO\nworth\tO\n$\tO\n36\tO\n.\tO\n\nNOW\tO\nAM\tO\nVERY\tO\nAPREHENSIVE\tO\nABOUT\tO\nTOSHIBA\tO\nLAPTOPS\tO\n.\tO\n\nI\tO\nspent\tO\n2200\tO\ndollars\tO\non\tO\na\tO\n\"\tO\ntop\tO\nof\tO\nthe\tO\nline\tO\nlaptop\tO\n\"\tO\n.\tO\n\nI\tO\nalso\tO\nown\tO\nan\tO\nHP\tO\nnotebook\tO\nand\tO\nit\tO\ndoes\tO\nn't\tO\neven\tO\ncome\tO\nclose\tO\n.\tO\n\nOur\tO\nApple\tO\n13.3\tO\nMacBook\tO\nPro\tO\nNotebook\tO\nComputer\tO\n(\tO\nZ0J80001\tO\n)\tO\nNotebook\tO\nand\tO\nhas\tO\nbecome\tO\nsuch\tO\nan\tO\nintegral\tO\npart\tO\nof\tO\ncompleting\tO\nour\tO\ndaily\tO\nneeds\tO\nand\tO\nsocial\tO\nnetworking\tO\n.\tO\n\nI\tO\nam\tO\nconstantly\tO\ntrying\tO\nto\tO\nuninstall\tO\nprograms\tB-aspectTerm\n,\tO\nclean\tO\ncookies\tO\n,\tO\nand\tO\ndelete\tO\nunused\tO\nfiles\tO\n.\tO\n\nThe\tO\ndv4\tO\nboasted\tO\na\tO\nfaster\tO\nprocessor\tB-aspectTerm\n,\tO\nmore\tO\nmemory\tB-aspectTerm\n,\tO\nand\tO\na\tO\nbigger\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nthan\tO\nmy\tO\nold\tO\ncomputer\tO\n,\tO\nplus\tO\na\tO\nbetter\tO\nquality\tO\nweb\tB-aspectTerm\ncam\tI-aspectTerm\n,\tO\nnicer\tO\nscreen\tB-aspectTerm\n,\tO\nand\tO\nmany\tO\nother\tO\nfeatures\tB-aspectTerm\n.\tO\n\nThe\tO\nonly\tO\ndownfall\tO\nis\tO\nthe\tO\nbattery\tB-aspectTerm\nonly\tO\nlast\tO\n1.5\tO\n-\tO\n2.0\tO\nhrs\tO\nwhen\tO\nnot\tO\nplugged\tO\nin\tO\n.\tO\n\nThe\tO\ngraphics\tB-aspectTerm\non\tO\nthis\tO\ncomputer\tO\nare\tO\nalso\tO\nstellar\tO\n-\tO\nvery\tO\nclear\tO\nand\tO\nvivid\tO\n.\tO\n\nAside\tO\nfrom\tO\nthe\tO\ntrial\tB-aspectTerm\nsoftware\tI-aspectTerm\nand\tO\nthe\tO\nshort\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n,\tO\nlack\tO\nof\tO\na\tO\nwebcam\tB-aspectTerm\n,\tO\nits\tO\ngreat\tO\n.\tO\n\nAs\tO\na\tO\ndie\tO\n-\tO\nhard\tO\nWindows\tB-aspectTerm\nenthusiast\tO\n,\tO\nI\tO\nshunned\tO\nthe\tO\nidea\tO\nof\tO\na\tO\nMac\tO\nuntil\tO\nthis\tO\npoint\tO\n.\tO\n\nI\tO\nthink\tO\nthat\tO\nif\tO\nit\tO\nis\tO\nthe\tO\nmotherboard\tB-aspectTerm\nagain\tO\nso\tO\nsoon\tO\nthat\tO\nthey\tO\nshould\tO\nreplace\tO\nit\tO\n.\tO\n\nif\tO\nthis\tO\ncomputer\tO\nevery\tO\nbreaks\tO\ndown\tO\non\tO\nme\tO\ni\tO\nwill\tO\nmost\tO\ndefinatly\tO\nget\tO\nthe\tO\nsame\tO\none\tO\nagain\tO\n.\tO\n\nI\tO\nhad\tO\na\tO\nMacBook\tO\nNotebook\tO\n,\tO\nand\tO\nit\tO\nhad\tO\nabsolutely\tO\nno\tO\nprotection\tO\nfrom\tO\nviruses\tO\n,\tO\nspyware\tO\n,\tO\nmalware\tO\n,\tO\netc\tO\n.\tO\n\nThe\tO\ncomputer\tO\nloads\tB-aspectTerm\nin\tO\nabout\tO\na\tO\n1/10th\tO\nof\tO\nthe\tO\ntime\tO\nthat\tO\nmy\tO\nPC\tO\ndid\tO\n,\tO\nand\tO\nI\tO\nhave\tO\nall\tO\nof\tO\nthe\tO\nprograms\tB-aspectTerm\nthat\tO\nwere\tO\non\tO\nmy\tO\nPC\tO\n.\tO\n\nI\tO\nmade\tO\nthe\tO\nright\tO\ndecision\tO\n.\tO\n\nIn\tO\nthe\tO\npast\tO\nfew\tO\nyears\tO\n,\tO\nI\tO\n've\tO\nhad\tO\nterrible\tO\nexperiences\tO\nwith\tO\nHP\tO\n.\tO\n\nOverall\tO\n,\tO\nit\tO\n's\tO\nok\tO\n.\tO\n\nGraphics\tB-aspectTerm\nare\tO\nclean\tO\nand\tO\nsharp\tO\n,\tO\ninternet\tB-aspectTerm\ninterfaces\tI-aspectTerm\nare\tO\nseamless\tO\n.\tO\n\nThe\tO\nnewer\tO\nblack\tB-aspectTerm\nkeyboard\tI-aspectTerm\ntook\tO\na\tO\nlittle\tO\nbit\tO\naway\tO\nfrom\tO\nthe\tO\nprevious\tO\ngray\tO\none\tO\nwhich\tO\nlooked\tO\nreally\tO\nslick\tO\n,\tO\nbut\tO\nit\tO\nis\tO\nstill\tO\na\tO\ngreat\tO\nnotebook\tO\n!\tO\n\nSony\tO\nparts\tO\nreliability\tO\nand\tO\nquality\tO\nof\tO\nservice\tB-aspectTerm\nis\tO\nrecenlty\tO\nthe\tO\nworst\tO\n.\tO\n\nI\tO\nam\tO\nvery\tO\nHappy\tO\n!\tO\n\nAs\tO\nwith\tO\nany\tO\nlaptop\tO\nnot\tO\npurchased\tO\nwith\tO\nsoftware\tB-aspectTerm\noptions\tI-aspectTerm\n,\tO\nit\tO\ncomes\tO\nwith\tO\na\tO\nlot\tO\nof\tO\nwhat\tO\nI\tO\nconsider\tO\nuseless\tO\napplications\tB-aspectTerm\n.\tO\n\nIts\tO\nOffice\tB-aspectTerm\ncompatible\tO\n,\tO\nbut\tO\nthe\tO\nfeatures\tB-aspectTerm\nand\tO\nits\tO\nfunctioning\tB-aspectTerm\nis\tO\nall\tO\nnew\tO\nagain\tO\nso\tO\nyou\tO\nmight\tO\nas\tO\nwell\tO\nsave\tO\nthe\tO\nmoney\tO\nand\tO\njust\tO\nlearn\tO\nthe\tO\npre\tO\ninstalled\tO\nmac\tO\nprograms\tB-aspectTerm\n.\tO\n\nI\tO\noccassionaly\tO\nuse\tO\nit\tO\nfor\tO\nwork\tO\nvia\tO\nVPN\tO\nand\tO\nit\tO\nhas\tO\nnot\tO\ngiven\tO\nme\tO\nany\tO\nproblems\tO\n.\tO\n\nI\tO\nsent\tO\nit\tO\nback\tO\nAND\tO\nTHEY\tO\nLOST\tO\nIT\tO\n.\tO\n\nIt\tO\njust\tO\nworks\tB-aspectTerm\nflawlessly\tO\n!\tO\n\nDo\tO\nyou\tO\nthink\tO\nI\tO\npurposely\tO\n\"\tO\ndestroy\tO\n\"\tO\nmy\tO\nnetbook\tO\n,\tO\nso\tO\nthat\tO\nI\tO\ncan\tO\ndemand\tO\na\tO\nnew\tO\nset\tO\n?\tO\nDo\tO\nyou\tO\nthink\tO\nit\tO\n's\tO\nfun\tO\nto\tO\ntake\tO\npublic\tO\ntransport\tO\nall\tO\nthe\tO\nway\tO\nto\tO\nthe\tO\nservice\tB-aspectTerm\ncenter\tI-aspectTerm\nand\tO\nget\tO\na\tO\nnon\tO\n-\tO\nsatisfactory\tO\nsolution\tO\n?\tO\nOr\tO\nrather\tO\nNO\tO\nsolution\tO\n.\tO\n\nI\tO\n'm\tO\nhaving\tO\nthe\tO\nlaptop\tO\nreturned\tO\nunrepaired\tO\nsince\tO\npaying\tO\n$\tO\n176\tO\nevery\tO\n3\tO\nmonths\tO\njust\tO\nis\tO\nn't\tO\nworth\tO\nit\tO\n(\tO\nthat\tO\n's\tO\nabout\tO\nhow\tO\nlong\tO\nthe\tO\nport\tO\nseems\tO\nto\tO\nlast\tO\n)\tO\n.\tO\n\nOk\tO\nfirst\tO\n.\tO\n\nSo\tO\nif\tO\nyou\tO\nmove\tO\nlaptop\tO\na\tO\nlot\tO\n,\tO\nit\tO\nmight\tO\nget\tO\nloose\tO\n,\tO\nhowever\tO\nit\tO\nsits\tO\npretty\tO\ntightly\tO\n.\tO\n\nanother\tO\nsatisfied\tO\ncustomer\tO\n.\tO\n\nalso\tO\nthe\tO\nbattery\tO\nis\tB-aspectTerm\ncompletely\tO\nshot\tO\n.\tO\n\nHighly\tO\nrecommended\tO\n!\tO\n\n/\tO\nawesome\tO\ncooling\tB-aspectTerm\nsystem/\tI-aspectTerm\nmuch\tO\nbetter\tO\ngrafics\tB-aspectTerm\ncard\tI-aspectTerm\n(\tO\nATI\tO\n5870\tO\n)\tO\n/\tO\n8\tB-aspectTerm\nGB\tI-aspectTerm\nRAM/\tI-aspectTerm\nLED\tB-aspectTerm\nbacklit\tI-aspectTerm\nscreen\tI-aspectTerm\n...\tO\n\nThe\tO\nbiggest\tO\nproblem\tO\nis\tO\nthat\tO\nthe\tO\nbox\tO\nhad\tO\nno\tO\ninstructions\tB-aspectTerm\nin\tO\nit\tO\n.\tO\n\nBut\tO\nafter\tO\nusing\tO\nit\tO\na\tO\ncouple\tO\nof\tO\nweeks\tO\n,\tO\nthe\tO\noverall\tO\noperation\tB-aspectTerm\nis\tO\npoor\tO\n.\tO\n\nWill\tO\nnot\tO\nbuy\tO\nanother\tO\nToshiba\tO\n,\tO\nthis\tO\nis\tO\nmy\tO\nsecond\tO\n,\tO\nnot\tO\nhappy\tO\nw/\tO\neither\tO\n.\tO\n\nCompared\tO\nto\tO\nsimilarly\tO\nspec'd\tO\nPCs\tO\n,\tO\nthis\tO\nmachine\tO\nis\tO\ngood\tO\nvalue\tB-aspectTerm\n,\tO\nwell\tO\nbuilt\tB-aspectTerm\nand\tO\nworks\tB-aspectTerm\neasily\tO\nright\tO\nout\tO\nof\tO\nthe\tO\nbox\tO\n.\tO\n\nThe\tO\ncool\tO\nthing\tO\nabout\tO\nthe\tO\nMac\tO\nBook\tO\nwas\tO\nthat\tO\nI\tO\nwent\tO\non\tO\nmy\tO\nhoneymoon\tO\nand\tO\nshot\tO\na\tO\nbunch\tO\nof\tO\npictures\tO\nand\tO\nmovies\tO\nwith\tO\nmy\tO\niPhone\tO\n,\tO\nthen\tO\nI\tO\ncame\tO\nback\tO\nand\tO\nput\tO\nthem\tO\nonto\tO\nmy\tO\nMacbook\tO\nand\tO\nmade\tO\na\tO\npretty\tO\ngood\tO\nDVD\tO\nmovie\tO\nwith\tO\nall\tO\nthe\tO\npictures\tO\nand\tO\nvideos\tO\nfrom\tO\nmy\tO\ntrip\tO\n.\tO\n\nfor\tO\ntwo\tO\nmonths\tO\n,\tO\nwhen\tO\nYOU\tO\nGUESSED\tO\nIT\tO\n.\tO\n\nThis\tO\nwas\tO\nmy\tO\nfirst\tO\nMacBook\tO\npurchase\tO\never\tO\n.\tO\n\nScreen\tB-aspectTerm\nis\tO\ncrystal\tO\nclear\tO\nand\tO\nthe\tO\nsystem\tB-aspectTerm\nis\tO\nvery\tO\nresponsive\tO\n.\tO\n\nI\tO\nwill\tO\nstack\tO\nit\tO\nup\tO\nagainst\tO\nlaptops\tO\nthat\tO\ncost\tB-aspectTerm\ntwice\tO\nas\tO\nmuch\tO\nany\tO\nday\tO\n.\tO\n\nQuite\tO\nsimply\tO\nthis\tO\nis\tO\nthe\tO\nbest\tO\nlaptop\tO\nI\tO\nhave\tO\never\tO\nowned\tO\n.\tO\n\nOr\tO\nthe\tO\ncursor\tB-aspectTerm\nwould\tO\nshow\tO\nup\tO\nsome\tO\nplace\tO\nelse\tO\n.\tO\n\nThe\tO\nnewer\tO\nMacBook\tO\nthat\tO\nI\tO\nhave\tO\npurchased\tO\nis\tO\none\tO\nof\tO\nthe\tO\nbest\tO\ncomputers\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nsome\tO\nexcellent\tO\ncomputer\tO\nand\tO\nhave\tO\nfound\tO\nI\tO\nhad\tO\nno\tO\nidea\tO\nwhat\tO\nto\tO\ndo\tO\nwith\tO\nthem\tO\n\nAs\tO\nit\tO\nturns\tO\nout\tO\n,\tO\nI\tO\njust\tO\ndid\tO\nn't\tO\nknow\tO\nany\tO\nbetter\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nfriends\tO\nwith\tO\nAcers\tO\nwho\tO\nseem\tO\nto\tO\nhave\tO\nhad\tO\nsimilar\tO\nor\tO\nexact\tO\nsame\tO\nproblems\tO\n.\tO\n\nWhat\tO\ncan\tO\nI\tO\nsay\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\noperate\tB-aspectTerm\nand\tO\nI\tO\nhave\tO\nalready\tO\nordered\tO\nmore\tO\nsoftware\tB-aspectTerm\nand\tO\ngadgets\tB-aspectTerm\nfor\tO\nmy\tO\nnew\tO\nRolls\tO\nRoyce\tO\nof\tO\nlaptops\tO\n.\tO\n\nWhat\tO\n's\tO\nalso\tO\ninteresting\tO\nis\tO\nthis\tO\nsurvey\tO\nchanged\tO\nmy\tO\nratings\tO\nthe\tO\nfirst\tO\ntime\tO\nI\tO\nsubmitted\tO\nit\tO\nin\tO\ncase\tO\nit\tO\ndoes\tO\nn't\tO\nkeep\tO\nwhat\tO\nI\tO\nput\tO\nhere\tO\nare\tO\nmy\tO\naratings\tO\n\nit\tO\nmight\tO\nbe\tO\nsomething\tO\ndeep\tO\nwithin\tO\nWindows\tB-aspectTerm\n,\tO\nfor\tO\nI\tO\nwas\tO\nunable\tO\nto\tO\ncreate\tO\na\tO\ndisk\tB-aspectTerm\nimage\tI-aspectTerm\non\tO\nmy\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nI\tO\nhad\tO\na\tO\ntoshiba\tO\nfor\tO\n10\tO\nyears\tO\n.\tO\n\nThe\tO\ntrack\tB-aspectTerm\npad\tI-aspectTerm\nto\tO\nme\tO\nis\tO\nwhat\tO\nreally\tO\nstands\tO\nout\tO\nthough\tO\n,\tO\nyou\tO\ncan\tO\ndo\tO\nseveral\tO\ndifferent\tO\nthings\tO\nwith\tO\nit\tO\njust\tO\ndepending\tO\non\tO\nhow\tO\nmany\tO\nfingers\tO\nyou\tO\nuse\tO\non\tO\nthe\tO\ntrack\tB-aspectTerm\npad\tI-aspectTerm\n,\tO\nawesome\tO\nthinking\tO\nApple\tO\n!\tO\n\nNow\tO\nI\tO\nhad\tO\nnot\tO\ntried\tO\nto\tO\nuse\tO\nthis\tO\nsince\tO\nthe\tO\ndisc\tO\ndrive\tB-aspectTerm\nhad\tI-aspectTerm\nbeen\tO\nreplaced\tO\nand\tO\nafter\tO\ntaking\tO\nit\tO\nback\tO\nto\tO\nthe\tO\nGeek\tO\nSquad\tO\nI\tO\nfound\tO\nout\tO\nthey\tO\nhad\tO\naccidently\tO\nnot\tO\nused\tO\nthe\tO\nright\tO\ndrive\tO\nwhen\tB-aspectTerm\nthey\tO\nreplaced\tO\nthe\tO\nfirst\tO\none\tO\n,\tO\nso\tO\nback\tO\nit\tO\nwent\tO\nto\tO\nget\tO\nthe\tO\ncorrect\tO\ndrive\tO\n.\tB-aspectTerm\n\nFirst\tO\n,\tO\nyou\tO\nll\tO\ndiscover\tO\nthat\tO\nthe\tO\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\nprogram\tI-aspectTerm\nknown\tO\nas\tO\nAppleworks\tO\nrarely\tO\ntranslates\tO\nperfectly\tO\non\tO\nanyone\tO\nelse\tO\ns\tO\ncomputer\tO\n,\tO\nif\tO\nit\tO\ntranslates\tO\nat\tO\nall\tO\n.\tO\n\nshe\tO\nca\tO\nn't\tO\ntell\tO\nthe\tO\ndifference\tO\nbetween\tO\nit\tO\nand\tO\nher\tO\nregular\tO\ndesktop\tO\nsystem\tO\n.\tO\n\nWith\tO\nin\tO\nweeks\tO\nof\tO\npurchasing\tO\nmy\tO\ncomputer\tO\nis\tO\nbegan\tO\nto\tO\nslow\tO\ndown\tO\n.\tO\n\nIt\tO\ndoes\tO\nn't\tO\nbother\tO\nme\tO\nthough\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nthis\tO\nlaptop\tO\nfor\tO\nabout\tO\na\tO\nmonth\tO\nnow\tO\n.\tO\n\nI\tO\nalready\tO\nhave\tO\na\tO\nHP\tO\nlaptop\tO\nI\tO\nbought\tO\nlast\tO\nyear\tO\nthat\tO\n's\tO\nstandard\tO\nsize\tB-aspectTerm\n.\tO\n\nIt\tO\nwas\tO\nokay\tO\nfor\tO\nover\tO\na\tO\nweek\tO\nbefore\tO\nthe\tO\nblue\tO\nscreens\tO\nstarted\tO\noccuring\tO\nagain\tO\n.\tO\n\nEnglish\tO\nmust\tO\nhave\tO\nbeen\tO\nhis\tO\nthird\tO\nor\tO\nfourth\tO\nlanguage\tO\n.\tO\n\nBattery\tB-aspectTerm\nis\tO\nnot\tO\nupgradable\tO\nto\tO\na\tO\nlonger\tO\nlife\tO\nbattery\tB-aspectTerm\n.\tO\n\nI\tO\nam\tO\njust\tO\nONE\tO\nof\tO\nthe\tO\nmillion\tO\ncustomers\tO\n.\tO\n\nit\tO\nhas\tO\ntimes\tO\nwere\tO\nit\tO\nfreezes\tO\nfor\tO\n10\tO\nseconds\tO\nand\tO\nthen\tO\nstarts\tO\nagain\tO\n.\tO\n\napple\tO\nhas\tO\na\tO\nreputation\tO\nand\tO\nis\tO\nwell\tO\nknown\tO\nfor\tO\nits\tO\neasy\tO\nusage\tB-aspectTerm\n.\tO\n\nReturned\tO\nlaptop\tO\nfor\tO\na\tO\n3rd\tO\nrepair\tO\nand\tO\nit\tO\ncame\tO\nback\tO\nwith\tO\nprevious\tO\nproblems\tO\nfixed\tO\n(\tO\nexcept\tO\nfor\tO\nspeaker\tB-aspectTerm\ngrill\tI-aspectTerm\n)\tO\nbut\tO\nthe\tO\nunit\tO\nstarted\tO\nlocking\tO\nup\tO\nduring\tO\nuse\tO\nand\tO\neventually\tO\nwould\tO\nnot\tO\noperate\tO\nat\tO\nall\tO\n.\tO\n\nI\tO\njust\tO\nplug\tO\nthis\tO\ninto\tO\nmy\tO\n22\tB-aspectTerm\n\"\tI-aspectTerm\nMonitor\tI-aspectTerm\nand\tO\nthe\tO\nspeedy\tO\nMacOSX\tB-aspectTerm\nperforms\tO\njust\tO\nas\tO\nwell\tO\non\tO\nthis\tO\ndual\tB-aspectTerm\n-\tI-aspectTerm\ncore\tI-aspectTerm\nthat\tO\nmy\tO\nDell\tO\ndid\tO\nwith\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nwith\tO\na\tO\nquad\tB-aspectTerm\n-\tI-aspectTerm\ncore\tI-aspectTerm\n.\tO\n\nLove\tO\nthe\tO\ngraphics\tB-aspectTerm\n,\tO\nawesome\tO\nprograms\tB-aspectTerm\n(\tO\nincluding\tO\nGarageband\tB-aspectTerm\n)\tO\n,\tO\nand\tO\nreally\tO\ncool\tO\ndefault\tB-aspectTerm\nbackground\tI-aspectTerm\n.\tO\n\nScreen\tB-aspectTerm\n,\tO\nkeyboard\tB-aspectTerm\n,\tO\nand\tO\nmouse\tB-aspectTerm\n:\tO\nIf\tO\nyou\tO\nca\tO\nnt\tO\nsee\tO\nyourself\tO\nspending\tO\nthe\tO\nextra\tO\nmoney\tO\nto\tO\njump\tO\nup\tO\nto\tO\na\tO\nMac\tO\nthe\tO\nbeautiful\tO\nscreen\tB-aspectTerm\n,\tO\nresponsive\tO\nisland\tB-aspectTerm\nbacklit\tI-aspectTerm\nkeyboard\tI-aspectTerm\n,\tO\nand\tO\nfun\tO\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\nmouse\tI-aspectTerm\nis\tO\nworth\tO\nthe\tO\nextra\tO\nmoney\tO\nto\tO\nme\tO\nalone\tO\n.\tO\n\nI\tO\nam\tO\ntaking\tO\nback\tO\ntoday\tO\n.\tO\n\nMy\tO\nparents\tO\nbought\tO\nit\tO\nfor\tO\nme\tO\nas\tO\na\tO\ngraduation\tO\ngift\tO\n,\tO\nand\tO\ni\tO\n'm\tO\ntotally\tO\n(\tO\nalmost\tO\nkind\tO\nof\tO\nmaybe\tO\ndefinitely\tO\n)\tO\nobsessed\tO\nwith\tO\nit\tO\n.\tO\n\nThe\tO\nMacBook\tO\nis\tO\nway\tO\ntoo\tO\noverpriced\tO\nfor\tO\nsomething\tO\nso\tO\nsimple\tO\nand\tO\nchaotic\tO\n.\tO\n\n-Complied\tO\nto\tO\ntheir\tO\nprotocol\tO\n,\tO\ncalled\tO\nnumber\tO\n,\tO\nmade\tO\n\"\tO\ncase\tO\n\"\tO\n,\tO\ngot\tO\nan\tO\nemail\tO\naddress\tO\nto\tO\nsend\tO\ncomplaint\tO\n.\tO\n\nThe\tO\nOS\tB-aspectTerm\ntakes\tO\nsome\tO\ngetting\tO\nused\tO\nto\tO\nespecially\tO\nafter\tO\nbeing\tO\na\tO\nWindows\tB-aspectTerm\nuser\tO\nfor\tO\nso\tO\nlong\tO\nbut\tO\nthe\tO\nlearning\tO\ncurve\tO\nis\tO\nso\tO\nworth\tO\nit\tO\n!\tO\n\nIt\tO\nquit\tO\nworking\tO\nwithin\tO\na\tO\nweeks\tO\ntime\tO\n.\tO\n\nbut\tO\nafter\tO\ni\tO\ngot\tO\nused\tO\nto\tO\nit\tO\ni\tO\nlove\tO\nit\tO\n.\tO\n\nI\tO\nalso\tO\npurchased\tO\niWork\tB-aspectTerm\nto\tO\ngo\tO\nwith\tO\nit\tO\nwhich\tO\nhas\tO\nprograms\tB-aspectTerm\nfor\tO\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\n,\tO\nspreadsheets\tB-aspectTerm\n,\tO\nand\tO\npresentations\tB-aspectTerm\n(\tO\nsimilar\tO\nto\tO\nMicrosoft\tB-aspectTerm\nOffice\tI-aspectTerm\n)\tO\n.\tO\n\nAfter\tO\n4\tO\ndays\tO\n,\tO\nbeing\tO\ndenied\tO\n6\tO\ntimes\tO\nand\tO\ntold\tO\noff\tO\nonce\tO\n,\tO\nI\tO\nmanaged\tO\nto\tO\nget\tO\nthrough\tO\nand\tO\nwas\tO\nable\tO\nto\tO\nsend\tO\nthem\tO\na\tO\nscanned\tO\ncopy\tO\nof\tO\nthe\tO\nreceipt\tO\n.\tO\n\nOverall\tO\n,\tO\nI\tO\nexperienced\tO\na\tO\nhuge\tO\nchange\tO\nin\tO\nthat\tO\nmy\tO\nmac\tO\nruns\tB-aspectTerm\npretty\tO\nfast\tO\ncompared\tO\nto\tO\nmy\tO\nold\tO\nPC\tO\n.\tO\n\nWhen\tO\nI\tO\ngot\tO\nthe\tO\ncomputer\tO\nback\tO\nand\tO\nrealizwed\tO\nit\tO\nstill\tO\nwas\tO\nnot\tO\ncorrect\tO\nHP\tO\ntold\tO\nme\tO\nit\tO\nwas\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\nand\tO\nnow\tO\nit\tO\nwas\tO\nmy\tO\nproblem\tO\n.\tO\n\nIt\tO\nalso\tO\ncame\tO\nwith\tO\na\tO\nbuilt\tB-aspectTerm\nit\tI-aspectTerm\nweb\tI-aspectTerm\ncam\tI-aspectTerm\nwhich\tO\nis\tO\ngreat\tO\nbecause\tO\nI\tO\ncan\tO\nsee\tO\nan\tO\ncommunicate\tO\nwith\tO\nmy\tO\nfamily\tO\nmembers\tO\nback\tO\nhome\tO\n.\tO\n\nGood\tO\nmonitor\tB-aspectTerm\nand\tO\nperformed\tB-aspectTerm\nwell\tO\n.\tO\n\nThey\tO\nare\tO\nclosed\tO\nat\tO\n9\tO\npm\tO\neastern\tO\n.\tO\n\nIn\tO\nthose\tO\nthree\tO\nyears\tO\n,\tO\nI\tO\n've\tO\nhad\tO\na\tO\ncouple\tO\nof\tO\nminor\tO\nproblems\tO\nand\tO\nboth\tO\nwere\tO\nresolved\tO\nby\tO\nApple\tO\nquickly\tO\nand\tO\neasily\tO\n.\tO\n\nAlthough\tO\nmy\tO\nmodel\tO\nwas\tO\nlisted\tO\nas\tO\nrecalled\tO\n,\tO\nHP\tO\ndenied\tO\nmy\tO\nclaim\tO\n.\tO\n\nIt\tO\nwas\tO\nsecure\tO\nand\tO\neasy\tO\nto\tO\nnavigate\tB-aspectTerm\n.\tO\n\nI\tO\nwas\tO\na\tO\nlittle\tO\nweary\tO\nat\tO\npurchasing\tO\nanother\tO\n13\tO\n\"\tO\nmacbook\tO\nalmost\tO\n2\tO\nyears\tO\nlater\tO\nbut\tO\nt\tO\nlooks\tO\nlike\tO\nthe\tO\nnewer\tO\nmacbooks\tO\nhave\tO\ngotten\tO\nits\tO\ncurrent\tO\nline\tO\nof\tO\ngraphics\tB-aspectTerm\ncards\tI-aspectTerm\nin\tO\norder\tO\nthis\tO\ntime\tO\naround\tO\n.\tO\n\nThe\tO\nmachine\tO\nhas\tO\na\tO\nbluray\tB-aspectTerm\nplayer\tI-aspectTerm\nthe\tO\nbook\tB-aspectTerm\nhas\tO\nno\tO\nmention\tO\nof\tO\nit\tO\nor\tO\nhow\tO\nto\tO\nconnect\tO\nit\tO\nto\tO\nyour\tO\nHDTV\tO\n.\tO\n\nI\tO\nam\tO\nloyal\tO\nto\tO\nApple\tO\n.\tO\n\nThey\tO\nare\tO\nby\tO\nfar\tO\nthe\tO\neasiest\tO\nsystems\tB-aspectTerm\nto\tO\nactually\tO\nlearn\tO\nabout\tO\ncomputers\tO\nwith\tO\n.\tO\n\nI\tO\nwill\tO\nbe\tO\npatient\tO\nfor\tO\nfew\tO\nmonths\tO\n.\tO\n\nthis\tO\napple\tO\nnavigates\tO\nyou\tO\nthru\tO\nthe\tO\nunexplored\tO\nworld\tO\nof\tO\nthe\tO\ninternet\tB-aspectTerm\n.\tO\n\nThis\tO\nwas\tO\npurchased\tO\nfor\tO\nmy\tO\ndaughter\tO\nand\tO\nI\tO\nwas\tO\npleasantly\tO\nsurprised\tO\n.\tO\n\nFinally\tO\nset\tO\nthe\tO\nunit\tO\nback\tO\nto\tO\nHP\tO\nafter\tO\na\tO\nmonth\tO\nof\tO\nhell\tO\n.\tO\n\nI\tO\ncould\tO\nn't\tO\nafford\tO\na\tO\nnew\tO\nmac\tO\n,\tO\nso\tO\nI\tO\nbought\tO\na\tO\nPC\tO\ninstead\tO\n.\tO\n\nThe\tO\nvideo\tB-aspectTerm\ncard\tI-aspectTerm\nis\tO\ngreat\tO\nfor\tO\nmedia\tB-aspectTerm\n,\tO\nand\tO\nabove\tO\naverage\tO\nfor\tO\ngaming\tB-aspectTerm\n,\tO\nbut\tO\nnot\tO\na\tO\ngamers\tO\nfirst\tO\nchoice\tO\n.\tO\n\nIt\tO\nwas\tO\nalways\tO\ngetting\tO\nfroze\tO\nup\tO\n.\tO\n\nmy\tO\ninformation\tO\nwas\tO\nall\tO\nlost\tO\n(\tO\nmy\tO\nfault\tO\n,\tO\nI\tO\nknow\tO\n,\tO\nbut\tO\nI\tO\nnever\tO\nthought\tO\nI\tO\nwould\tO\nneed\tO\nto\tO\nback\tO\nup\tO\nmy\tO\ninformation\tO\non\tO\na\tO\nbrand\tO\nnew\tO\nMac\tO\n,\tO\nthe\tO\nparagon\tO\nof\tO\nall\tO\ncomputers\tO\n!\tO\n\nBut\tO\nno\tO\none\tO\ncould\tO\ntell\tO\nme\tO\nwhen\tO\nmy\tO\npart\tO\nwould\tO\nbe\tO\nshipped\tO\nnor\tO\ncould\tO\nthey\tO\ntell\tO\nme\tO\nwhere\tO\nto\tO\nbuy\tO\nit\tO\nON\tO\nTHEIR\tO\nWEBSITE\tO\n!\tO\n!\tO\n!\tO\n\nI\tO\ngot\tO\nthe\tO\nblue\tO\nscreen\tO\nof\tO\ndeath\tO\nthe\tO\nfirst\tO\nmonth\tO\nI\tO\ngot\tO\nit\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nthird\tO\nMacBook\tO\nPro\tO\nin\tO\nour\tO\nfamily\tO\n.\tO\n\nApple\tO\ncontinues\tO\nto\tO\nshine\tO\nand\tO\nprovide\tO\na\tO\nmuch\tO\nmore\tO\nenjoyable\tO\ncomputer\tO\nexperience\tO\n!\tO\n\nI\tO\nhad\tO\nof\tO\ncourse\tO\nbought\tO\na\tO\n3\tB-aspectTerm\nyear\tI-aspectTerm\nwarranty\tI-aspectTerm\n,\tO\nso\tO\nI\tO\nsent\tO\nit\tO\nin\tO\nto\tO\nbe\tO\nreplaced\tO\nand\tO\n(\tO\nalmost\tO\n2\tO\nmonths\tO\nlater\tO\n)\tO\nthe\tO\ndv4\tO\nis\tO\nwhat\tO\nthe\tO\nsent\tO\nme\tO\nas\tO\na\tO\nreplacement\tO\n.\tO\n\nApparently\tO\nthere\tO\nis\tO\na\tO\nmanufacturing\tO\ndefect\tO\n,\tO\nsomething\tO\nwith\tO\nthe\tO\namount\tO\nof\tO\nthermal\tB-aspectTerm\npaste\tI-aspectTerm\n.\tO\n\nDespite\tO\nthe\tO\nclaims\tO\nof\tO\nthe\tO\nApple\tO\napologists\tO\n(\tO\na\tO\nvice\tO\nof\tO\nwhich\tO\nI\tO\nam\tO\nrecently\tO\nmyself\tO\nreformed\tO\n)\tO\nthe\tO\ninternals\tB-aspectTerm\nof\tO\nMac\tO\nlaptops\tO\nare\tO\nNO\tO\ndifferent\tO\nfrom\tO\nPCs\tO\n'\tO\nat\tO\nthis\tO\npoint\tO\n.\tO\n\nTook\tO\nseveral\tO\nhours\tO\nwith\tO\ncustomer\tB-aspectTerm\nsupport\tI-aspectTerm\nbefore\tO\nI\tO\ncould\tO\neven\tO\nstart\tO\nthe\tO\nPC\tO\nout\tO\nof\tO\nthe\tO\nbox\tO\n.\tO\n\nAsus\tO\nfacial\tB-aspectTerm\nrecognition\tI-aspectTerm\ndoes\tO\nn't\tO\nwork\tO\nand\tO\nwindows\tB-aspectTerm\nlogon\tI-aspectTerm\nis\tO\nn't\tO\neither\tO\n.\tO\n\nWindows\tB-aspectTerm\nVista\tI-aspectTerm\nmakes\tO\nthis\tO\ncomputer\tO\nalmost\tO\nunusable\tO\nfor\tO\nonline\tB-aspectTerm\nservice\tI-aspectTerm\n.\tO\n\nI\tO\ncontacted\tO\nAcer\tO\nand\tO\nthey\tO\nare\tO\ngiving\tO\nme\tO\nFREE\tO\nrecovery\tB-aspectTerm\nDVDs\tI-aspectTerm\n,\tO\nso\tO\ndo\tO\nn't\tO\ngo\tO\nand\tO\npay\tO\nfor\tO\nthem\tO\n,\tO\njust\tO\nask\tO\nfor\tO\nthem\tO\nand\tO\nthey\tO\nshould\tO\ngive\tO\nthem\tO\nto\tO\nyou\tO\n.\tO\n\nNow\tO\nwhen\tO\nI\tO\norder\tO\nI\tO\ndid\tO\nnot\tO\ngo\tO\nfull\tO\nscale\tO\nfor\tO\nthe\tO\nwebcam\tB-aspectTerm\nor\tO\nfull\tO\nkeyboard\tB-aspectTerm\nI\tO\nwanted\tO\nsomething\tO\nfor\tO\nbasics\tO\nof\tO\nbeing\tO\neasy\tO\nto\tO\ncarry\tB-aspectTerm\nwhen\tO\nI\tO\nuse\tO\ncrutchs\tO\nor\tO\nwheelchair\tO\nand\tO\nwith\tO\na\tO\nbackpack\tO\nlaptop\tO\nbag\tO\n.\tO\n\nCan\tO\nlisten\tO\nto\tO\nmy\tO\nmusic\tO\nand\tO\nwatch\tO\nmy\tO\nvideos\tO\nwith\tO\nease\tO\nand\tO\nwith\tO\na\tO\ngreat\tO\ndisplay\tB-aspectTerm\n.\tO\n\nOtherwise\tO\n,\tO\nall\tO\nother\tO\nfeatures\tB-aspectTerm\nare\tO\na\tO\n1\tO\n\nSo\tO\nin\tO\nlate\tO\nMarch\tO\n,\tO\nearly\tO\nApril\tO\n2009\tO\nI\tO\nwas\tO\nwithout\tO\nit\tO\nagain\tO\nfor\tO\na\tO\ncouple\tO\nweeks\tO\nwhile\tO\nI\tO\nhad\tO\nonline\tO\ncourses\tO\nI\tO\nhad\tO\nto\tO\ncomplete\tO\nand\tO\nmy\tO\nfiance\tO\nwas\tO\nin\tO\nAfghanistan\tO\nand\tO\nweb\tO\nconferencing\tO\nwas\tO\nthe\tO\nbest\tO\ncommunication\tO\nmethod\tO\nwe\tO\nhad\tO\n.\tO\n\nThe\tO\nperformance\tB-aspectTerm\nis\tO\nawesome\tO\n.\tO\n\nI\tO\npondered\tO\nvery\tO\nlong\tO\nover\tO\nthis\tO\ndecision\tO\n.\tO\n\nThis\tO\nthing\tO\nsucks\tO\n!\tO\n\nI\tO\nLove\tO\nmy\tO\nnew\tO\ncomputer\tO\n!\tO\n\nOkay\tO\n,\tO\nlet\tO\n's\tO\njust\tO\nstart\tO\nout\tO\nby\tO\nsaying\tO\nI\tO\nam\tO\nin\tO\nno\tO\nway\tO\na\tO\ncomputer\tO\ntechy\tO\n.\tO\n\nIt\tO\nwas\tO\na\tO\nWaste\tO\nof\tO\nmoney\tO\nfrom\tO\nday\tO\none\tO\n!\tO\n\nI\tO\n'm\tO\nnew\tO\n-\tO\njust\tO\nswitched\tO\nfrom\tO\nyears\tO\nof\tO\nPC\tO\nfrustration\tO\n.\tO\n\nSo\tO\nI\tO\ngot\tO\nanother\tO\nnetbook\tO\nwhich\tO\nI\tO\nlove\tO\n!\tO\n\nBut\tO\nin\tO\nfact\tO\nit\tO\nis\tO\ntotally\tO\nthe\tO\nopposite\tO\n.\tO\n\nThe\tO\ndisplay\tB-aspectTerm\nis\tO\nbeyond\tO\nhorrible\tO\n.\tO\n\nHe\tO\nLEFT\tO\nME\tO\n,\tO\ninstructions\tO\non\tO\nwhat\tO\nto\tO\ndo\tO\nwhen\tO\nthis\tO\ncomes\tO\nup\tO\n,\tO\nor\tO\nthat\tO\ncomes\tO\nup\tO\n......\tO\n\nIt\tO\n's\tO\na\tO\njoke\tO\n.\tO\n\nThere\tO\nis\tO\nhardly\tO\nany\tO\nmemory\tB-aspectTerm\non\tO\nthe\tO\ncomputer\tO\n's\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nActually\tO\n,\tO\nI\tO\nhad\tO\nnoticed\tO\nthe\tO\none\tO\non\tO\nthe\tO\nsales\tO\nfloor\tO\nalso\tO\ndid\tO\nn't\tO\nhave\tO\nsound\tB-aspectTerm\n!\tO\n\nI\tO\nstarted\tO\nhainv\tO\nproblems\tO\nwith\tO\nit\tO\nwithin\tO\nthe\tO\nfirst\tO\nmonth\tO\n.\tO\n\nNext\tO\n,\tO\nmost\tO\nAcer\tO\nlaptop\tO\nfans\tB-aspectTerm\nare\tO\non\tO\nthe\tO\nbottom\tO\nwhich\tO\nis\tO\nright\tO\non\tO\nyour\tO\nlaptop\tO\n.\tO\n\nthe\tO\nlaptop\tO\npreformed\tB-aspectTerm\npretty\tO\nwell\tO\n.\tO\n\nI\tO\n'm\tO\nhonestly\tO\nafraid\tO\nthat\tO\nit\tO\nwill\tO\nburn\tO\nme\tO\n,\tO\nit\tO\n's\tO\nthat\tO\nhot\tO\n!\tO\n\nBut\tO\nI\tO\ndo\tO\nn't\tO\nsee\tO\nit\tO\nas\tO\na\tO\nproblem\tO\n.\tO\n\nNumerous\tO\nproblems\tO\nover\tO\nthe\tO\nnext\tO\n3\tO\nweeks\tO\nuntil\tO\nI\tO\ngot\tO\nthe\tO\nblue\tO\nscreen\tO\nof\tO\ndeath\tO\nand\tO\nhad\tO\nto\tO\nsend\tO\nthe\tO\nPC\tO\nback\tO\nto\tO\nHP\tO\n.\tO\n\nI\tO\nthink\tO\nthis\tO\nwill\tO\nhappen\tO\nto\tO\nany\tO\nnew\tO\nversion\tO\nof\tO\ncomputer\tO\n/\tO\nphone\tO\nreleased\tO\nand\tO\nI\tO\nneed\tO\nto\tO\nwait\tO\nfor\tO\nthe\tO\nnext\tO\nset\tO\nof\tO\nupdates\tO\nto\tO\nhave\tO\nall\tO\nof\tO\nthis\tO\nfixed\tO\n.\tO\n\nThis\tO\none\tO\nhas\tO\nhad\tO\nthe\tO\nsame\tO\neffect\tO\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\nare\tO\na\tO\ngame\tO\nplayer\tO\nit\tO\nworks\tO\nwith\tO\nWorld\tO\nOf\tO\nWarcraft\tO\nwonderfully\tO\n.\tO\n\nThis\tO\ncomputer\tO\nis\tO\nabsolutely\tO\nAMAZING\tO\n!\tO\n!\tO\n!\tO\n\nSo\tO\nbuyer\tO\nbeware\tO\nwhen\tO\nbuying\tO\nToshiba\tO\n\nI\tO\nfound\tO\nthis\tO\nlaptop\tO\non\tO\nsale\tO\nfor\tO\nunder\tO\n6000\tO\nat\tO\nBest\tO\nBuy\tO\nwhich\tO\nwas\tO\na\tO\ngreat\tO\ndeal\tO\n!\tO\n\nI\tO\ngot\tO\nmy\tO\nMacBook\tO\nPro\tO\nbecause\tO\nI\tO\nwanted\tO\nto\tO\ndo\tO\nall\tO\nthe\tO\nstuff\tO\nI\tO\nneed\tO\nto\tO\ndo\tO\nwithout\tO\nworrying\tO\nabout\tO\nthe\tO\nsystem\tB-aspectTerm\nquitting\tO\non\tO\nme\tO\nor\tO\nfreezing\tO\nfor\tO\na\tO\nfew\tO\nminutes\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nApple\tO\nproducts\tO\n.\tO\n\nI\tO\nloved\tO\nthe\tO\nnetbook\tO\n(\tO\nminus\tO\nthe\tO\nfact\tO\nthat\tO\nit\tO\nwas\tO\nwindows\tB-aspectTerm\nOS\tI-aspectTerm\n)\tO\nuntil\tO\nthis\tO\nstarted\tO\nhappening\tO\n.\tO\n\nThe\tO\nminute\tO\nyou\tO\nfire\tO\nit\tO\nup\tO\nit\tO\n's\tO\nall\tO\ngood\tO\n,\tO\nvery\tO\neasy\tO\nuser\tB-aspectTerm\ninterface\tI-aspectTerm\n.\tO\n\nI\tO\nhave\tO\nhad\tO\ntwo\tO\nToshiba\tO\nsatellite\tO\ncomputers\tO\nand\tO\nwhile\tO\nthey\tO\nare\tO\nokay\tO\n,\tO\nthey\tO\nare\tO\nin\tO\nno\tO\nway\tO\ncomparable\tO\nto\tO\nthe\tO\nMac\tO\n.\tO\n\nI\tO\nactually\tO\ncontact\tO\nToshiba\tO\nbefore\tO\nI\tO\nstarted\tO\nhaving\tO\nproblem\tO\nand\tO\nwas\tO\ngiven\tO\nrun\tO\naround\tO\nafter\tO\nI\tO\nsupplied\tO\nserial\tO\nnumber\tO\nin\tO\norder\tO\nto\tO\ndelay\tO\nme\tO\nsending\tO\nin\tO\nlaptop\tO\nuntil\tO\nafter\tO\nwarrenty\tO\nexpired\tB-aspectTerm\n.\tO\n\nThey\tO\n're\tO\nabsolutely\tO\nuseless\tO\n,\tO\nunless\tO\nyou\tO\ncount\tO\nthe\tO\njoy\tO\nof\tO\nreleasing\tO\nanger\tO\nwhile\tO\nsmashing\tO\ninto\tO\nlittle\tO\npeices\tO\nagainst\tO\nthe\tO\nwall\tO\n.\tO\n\nwas\tO\na\tO\ngreat\tO\ndeal\tO\ni\tO\nwill\tO\ngive\tO\nthat\tO\n.\tO\n\nThere\tO\ns\tO\nalso\tO\niDVD\tB-aspectTerm\n,\tO\na\tO\nprogram\tB-aspectTerm\ndedicated\tO\nto\tO\nputting\tO\nall\tO\nyour\tO\nfavorite\tO\nmedia\tO\ntogether-\tO\nphotos\tO\n,\tO\nrecordings\tO\n,\tO\nvideo\tO\nprojects\tO\ninto\tO\none\tO\nprogram\tB-aspectTerm\nso\tO\nthat\tO\nyou\tO\ncan\tO\ncreate\tO\nthe\tO\nperfect\tO\nmemoir\tO\nfor\tO\nyour\tO\nparents\tO\n,\tO\nfamily\tO\n,\tO\nsiblings\tO\n,\tO\nand\tO\nany\tO\nother\tO\nperson\tO\nimportant\tO\nin\tO\nyour\tO\nlife\tO\nthat\tO\nthere\tO\nmay\tO\nbe\tO\n.\tO\n\nHis\tO\nlanguage\tO\nwas\tO\nso\tO\nbad\tO\nI\tO\nswore\tO\nI\tO\nwas\tO\ntaking\tO\nthe\tO\nturing\tO\ntest\tO\n,\tO\nand\tO\nit\tO\nwas\tO\nfailing\tO\n.\tO\n\nAfter\tO\nreplacing\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nthe\tO\nbattery\tB-aspectTerm\nstopped\tO\nworking\tO\n(\tO\n3\tO\nmonths\tO\nof\tO\nuse\tO\n)\tO\nwhich\tO\nwas\tO\nfrustrating\tO\n.\tO\n\nWas\tO\nthis\tO\nproduct\tO\nworth\tO\nmy\tO\ntime\tO\nand\tO\nmoney\tO\nto\tO\never\tO\nwant\tO\nto\tO\npurchase\tO\nanother\tO\nproducts\tO\nthat\tO\nis\tO\ntoshiba\tO\nor\tO\nrelating\tO\nto\tO\ntoshiba\tO\n?\tO\nProbably\tO\nnot\tO\never\tO\nagain\tO\n.\tO\n\nI\tO\nhave\tO\nused\tO\nPC\tO\n's\tO\nand\tO\nconverting\tO\nto\tO\nthis\tO\nMacBook\tO\nPro\tO\nwas\tO\neasy\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\neasy\tO\nto\tO\nsee\tO\nscreen\tB-aspectTerm\n,\tO\nand\tO\nIt\tO\nworks\tB-aspectTerm\nwell\tO\nfor\tO\nwork\tO\n,\tO\npersoal\tO\nor\tO\njust\tO\nplay\tO\n.\tO\n\nIf\tO\nwhat\tO\nyou\tO\nneed\tO\nis\tO\na\tO\nmachine\tO\nto\tO\ndo\tO\nsome\tO\nsurfing\tB-aspectTerm\n,\tO\nemail\tO\nchecking\tO\n,\tO\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\n,\tO\nand\tO\nwatching\tO\na\tO\nmovie\tO\nor\tO\ntwo\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nmachine\tO\nyou\tO\nwant\tO\n.\tO\n\n-Apparently\tO\n,\tO\ncontactus@euro.apple.com\tO\nis\tO\nnot\tO\na\tO\ngood\tO\naddress\tO\nto\tO\nsend\tO\ncomplaints\tO\n.\tO\n\nIt\tO\ndoes\tO\nn't\tO\nhave\tO\na\tO\nlot\tO\nof\tO\nfrills\tO\n,\tO\nbut\tO\nI\tO\ndid\tO\nn't\tO\nneed\tO\nany\tO\n,\tO\nand\tO\nbeing\tO\nable\tO\nto\tO\nbuy\tO\nwhat\tO\nI\tO\nneeded\tO\n,\tO\nand\tO\nnot\tO\nmore\tO\nthan\tO\nI\tO\nneeded\tO\nwas\tO\nvery\tO\nimportant\tO\n.\tO\n\nthe\tO\nmouse\tB-aspectTerm\npad\tI-aspectTerm\nand\tO\nbuttons\tB-aspectTerm\nare\tO\nthe\tO\nworst\tO\ni\tO\n've\tO\never\tO\nseen\tO\n.\tO\n\nI\tO\nam\tO\nsorry\tO\nthat\tO\nI\tO\npurchased\tO\nthis\tO\nlaptop\tO\n.\tO\n\nAwesome\tO\ngraphics\tB-aspectTerm\n!\tO\n\nIt\tO\nreally\tO\nis\tO\nperfect\tO\nfor\tO\nwork\tB-aspectTerm\nand\tO\nplay\tB-aspectTerm\n.\tO\n\nThe\tO\npro\tO\nis\tO\na\tO\ngreat\tO\nproduct\tO\n,\tO\nI\tO\nwish\tO\nthat\tO\nthe\tO\n13\tO\ninch\tO\nmodels\tO\ncame\tO\nwith\tO\nthe\tO\nIntel\tB-aspectTerm\ni\tI-aspectTerm\nprocessors\tI-aspectTerm\nand\tO\nhad\tO\na\tO\nmore\tO\ncomfortable\tO\nedge\tB-aspectTerm\n(\tO\nthe\tO\nedges\tB-aspectTerm\nhurt\tO\nmy\tO\nwrists\tO\n)\tO\n.\tO\n\nI\tO\nam\tO\na\tO\ncollege\tO\nstudent\tO\nand\tO\nit\tO\nhas\tO\nbeen\tO\nvery\tO\nuseful\tO\n.\tO\n\nThe\tO\napple\tO\nMacBook\tO\nis\tO\nthe\tO\nbest\tO\ninvestment\tO\nthat\tO\nI\tO\nhave\tO\never\tO\nmade\tO\n.\tO\n\nMy\tO\nsister\tO\nis\tO\nthe\tO\nelectronics\tO\nmanager\tO\nat\tO\nWal\tO\nMart\tO\nand\tO\nshe\tO\nsays\tO\nthat\tO\nHP\tO\nis\tO\nthe\tO\nbest\tO\n.\tO\n\nOne\tO\ndrawback\tO\nI\tO\nnoticed\tO\nwas\tO\nsound\tB-aspectTerm\nquality\tI-aspectTerm\nvia\tI-aspectTerm\nUSB\tI-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nsucked\tO\nthe\tO\njuice\tO\nfrom\tO\nmy\tO\nlaptop\tO\nand\tO\nwhen\tO\nthe\tO\nextended\tB-aspectTerm\nlife\tI-aspectTerm\nbattery\tI-aspectTerm\nwent\tO\nout\tO\nwe\tO\nwere\tO\nSOL\tO\nthere\tO\nto\tO\n,\tO\nso\tO\nmuch\tO\nfor\tO\nthat\tO\nwarranty\tB-aspectTerm\ncovering\tO\nall\tO\nthe\tO\nproducts\tO\nwe\tO\npurchased\tO\n.\tO\n\nI\tO\nneeded\tO\na\tO\nnew\tO\ncomputer\tO\nfor\tO\ngraduate\tO\nschool\tO\n(\tO\nhad\tO\nnever\tO\nowned\tO\na\tO\nlaptop\tO\nbefore\tO\n)\tO\n,\tO\nand\tO\nthe\tO\nonly\tO\nreason\tO\nI\tO\ndid\tO\nn't\tO\npurchase\tO\na\tO\nMac\tO\nwas\tO\nbecause\tO\nmy\tO\nschool\tO\n's\tO\nwebsite\tO\nstrongly\tO\nrecommended\tO\nstudents\tO\npurchase\tO\nPCs\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nanother\tO\nMac\tO\n,\tO\nbut\tO\nit\tO\ngot\tO\nslow\tO\ndue\tO\nto\tO\nan\tO\nolder\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n.\tO\n\nIf\tO\nyou\tO\nhave\tO\nthe\tO\nmoney\tO\nI\tO\nsuggest\tO\ngoing\tO\nfor\tO\nthe\tO\ni7\tO\n.\tO\n\nThat\tO\n's\tO\nvery\tO\npossible\tO\n,\tO\nbut\tO\nsince\tO\nthey\tO\ndo\tO\nn't\tO\nmake\tO\nWindows\tB-aspectTerm\nXP\tI-aspectTerm\ndrivers\tI-aspectTerm\nfor\tO\nthe\tO\nsound\tB-aspectTerm\ncard\tI-aspectTerm\nin\tO\nthis\tO\nmachine\tO\n,\tO\nI\tO\nwas\tO\nstuck\tO\nuntil\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\ncame\tO\nout\tO\n.\tO\n\nI'ts\tO\nnice\tO\nto\tO\nhave\tO\nthe\tO\nhigher\tO\n-\tO\nend\tO\nlaptops\tO\n,\tO\nbut\tO\nthis\tO\nfits\tO\nmy\tO\nbudget\tB-aspectTerm\nand\tO\nthe\tO\nfeatures\tB-aspectTerm\nI\tO\nneed\tO\n.\tO\n\nIt\tO\nis\tO\n,\tO\nhowever\tO\n,\tO\nvery\tO\nheavy\tO\n.\tO\n\nWas\tO\ndisappointed\tO\nto\tO\nfind\tO\nout\tO\nthat\tO\nthe\tO\nmodel\tO\nhad\tO\nbeen\tO\ndiscontinued\tO\n,\tO\napparently\tO\nbecause\tO\nof\tO\nknown\tO\nmotherboard\tB-aspectTerm\nproblems\tO\n.\tO\n\nWell\tO\n,\tO\nI\tO\nstarted\tO\nusing\tO\nGoogle\tB-aspectTerm\nChrome\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\na\tO\nlittle\tO\nbetter\tO\n,\tO\nbut\tO\nit\tO\nfreezes\tO\ntoo\tO\nsometimes\tO\n.\tO\n\nAlso\tO\nthe\tO\nspeakers\tB-aspectTerm\nare\tO\nnot\tO\nvery\tO\nloud\tO\n,\tO\nBut\tO\nit\tO\nis\tO\na\tO\nnetbook\tO\n.\tO\n\nLOVE\tO\nTHIS\tO\nLAPTOP\tO\nWONDERFUL\tO\nPRICE\tB-aspectTerm\nFOR\tO\nWHAT\tO\nYOU\tO\nGET\tO\n!\tO\n\nBut\tO\n,\tO\nat\tO\nthe\tO\nsame\tO\ntime\tO\nthey\tO\n(\tO\nthe\tO\ncompany\tO\n)\tO\nwould\tO\nnot\tO\nand\tO\ncould\tO\nnot\tO\ndo\tO\nanything\tO\nabout\tO\nmy\tO\nproblem\tO\n.\tO\n\nJust\tO\na\tO\nblack\tO\nscreen\tB-aspectTerm\n!\tO\n\nAll\tO\nyou\tO\nhave\tO\nto\tO\ndo\tO\nis\tO\nturn\tO\nit\tO\non\tO\nand\tO\nit\tO\nworks\tO\n.\tO\n\nA\tO\nkey\tO\ncontributor\tO\nthat\tO\nled\tO\nme\tO\nto\tO\nMac\tO\nis\tO\nthe\tO\nart\tB-aspectTerm\naspect\tI-aspectTerm\n.\tO\n\nEventually\tO\nmy\tO\nbattery\tB-aspectTerm\nwould\tO\nn't\tO\ncharge\tO\n,\tO\nso\tO\nunless\tO\nI\tO\nhad\tO\nit\tO\nplugged\tO\nin\tO\nit\tO\nwould\tO\nn't\tO\neven\tO\npower\tO\non\tO\n.\tO\n\nRecently\tO\nthere\tO\nare\tO\na\tO\nfew\tO\nincidents\tO\nthat\tO\nannoy\tO\nthe\tO\nhell\tO\nout\tO\nof\tO\nme\tO\n.\tO\n\nSave\tO\nyour\tO\nmoney\tO\nand\tO\ngo\tO\nfor\tO\na\tO\nbetter\tO\ndevice\tO\n.\tO\n\nI\tO\nhave\tO\nbeen\tO\na\tO\nPC\tO\nuser\tO\nsince\tO\nmiddle\tO\nschool\tO\n,\tO\nbut\tO\nin\tO\nmy\tO\nmid\tO\ntwenties\tO\nI\tO\ndecided\tO\nto\tO\nconvert\tO\nto\tO\nthe\tO\ndark\tO\nside\tO\n,\tO\nor\tO\nshould\tO\nI\tO\nsay\tO\nthe\tO\nbrighter\tO\nside\tO\nof\tO\nlife\tO\n.\tO\n\nPurchased\tO\nfor\tO\ndevelopment\tO\npurposes\tO\n,\tO\nbut\tO\nit\tO\nhas\tO\nturned\tO\ninto\tO\nmy\tO\neveryday\tO\nlaptop\tO\nas\tO\nwell\tO\nfor\tO\nsurfing\tB-aspectTerm\n,\tO\ne\tO\n-\tO\nmail\tO\n,\tO\netc\tO\n.\tO\n\nwithout\tO\nhaving\tO\nto\tO\nhave\tO\nextra\tO\nequipment\tO\nand/or\tO\ncomplicated\tO\nroutes\tO\nto\tO\ntake\tO\nto\tO\nbe\tO\nable\tO\nto\tO\ndo\tO\nso\tO\n.\tO\n\nMy\tO\nfirst\tO\nproblem\tO\nwas\tO\nwith\tO\nthe\tO\npre\tB-aspectTerm\n-\tI-aspectTerm\nloaded\tI-aspectTerm\nNorton\tI-aspectTerm\nFirewall\tI-aspectTerm\n/\tI-aspectTerm\nSecurity\tI-aspectTerm\nprogram\tI-aspectTerm\n.\tO\n\nI\tO\nhad\tO\na\tO\nUSB\tB-aspectTerm\nconnect\tI-aspectTerm\nbut\tO\n,\tO\ni\tO\nca\tO\nn't\tO\nuse\tO\nit\tO\nbecause\tO\nit\tO\nis\tO\nnot\tO\ncompatible\tO\n.\tO\n\nAccordingly\tO\n,\tO\nI\tO\nhave\tO\ndecided\tO\nto\tO\nNEVER\tO\npurchase\tO\nanother\tO\nHP\tO\nproduct\tO\n(\tO\nmy\tO\nfive\tO\nyear\tO\nold\tO\nCompaq\tO\n)\tO\nlasted\tO\n5-years\tO\nbefore\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\ncrashed\tO\n.\tO\n\nI\tO\nordered\tO\nfour\tO\nD620\tO\nlaptops\tO\n.\tO\n\nI\tO\nknow\tO\nthat\tO\neveryone\tO\nthinks\tO\nMacs\tO\nare\tO\noverpriced\tO\nand\tO\noverrated\tO\n,\tO\nbut\tO\nonce\tO\nyou\tO\nget\tO\npast\tO\nthe\tO\ninitial\tO\nexpense\tB-aspectTerm\nyou\tO\n'll\tO\nfind\tO\nthat\tO\nthey\tO\n're\tO\nworth\tO\nevery\tO\npenny\tO\n(\tO\nbesides\tO\n,\tO\nthere\tO\n's\tO\nalways\tO\nthe\tO\nfinancing\tO\nplan\tO\nthat\tO\nBest\tO\nBuy\tO\noffers\tO\n)\tO\n.\tO\n\nI\tO\nsaw\tO\nthis\tO\none\tO\n,\tO\nand\tO\nI\tO\nhave\tO\nthe\tO\nmost\tO\ndifficult\tO\ntime\tO\ntrying\tO\nto\tO\nuse\tO\nthem\tO\n,\tO\nthey\tO\n've\tO\nmade\tO\ngreat\tO\ndust\tO\ncollectors\tO\n,\tO\nI\tO\nhate\tO\nputting\tO\nthis\tO\ncomputer\tO\ndown\tO\n\nI\tO\nam\tO\nnot\tO\ngoing\tO\nto\tO\nsit\tO\nhere\tO\nand\tO\ncomplain\tO\nabout\tO\nit\tO\nnot\tO\nhaving\tO\na\tO\ncd\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nwhat\tO\nnot\tO\nbecause\tO\nit\tO\nis\tO\na\tO\nnetbook\tO\n,\tO\nit\tO\nis\tO\nmade\tO\nto\tO\nbe\tO\ncompact\tO\nand\tO\nif\tO\nyou\tO\nwant\tO\nall\tO\nthe\tO\nother\tO\nstuff\tO\nget\tO\na\tO\nlaptop\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\ntrackpad\tI-aspectTerm\n.\tO\n\nI\tO\nwas\tO\npsyched\tO\n.\tO\n\nI\tO\nabsolutely\tO\nlove\tO\nmy\tO\nmac\tO\n!\tO\n\nFrom\tO\nthe\tO\nsecond\tO\nyou\tO\nopen\tO\nthe\tO\nbox\tO\nyou\tO\nwill\tO\nfall\tO\nin\tO\nlove\tO\nwith\tO\nthis\tO\ncomputer\tO\n!\tO\n\nHP\tO\nis\tO\nmore\tO\ninterested\tO\nin\tO\nselling\tO\nextended\tB-aspectTerm\nwarranties\tI-aspectTerm\n(\tO\nwhich\tO\ncost\tB-aspectTerm\nmore\tO\nthan\tO\nthe\tO\nnetbook\tO\nnew\tO\n)\tO\nthen\tO\nthey\tO\nare\tO\nin\tO\nhelping\tO\nor\tO\nfixing\tO\n.\tO\n\nIt\tO\nwould\tO\nnot\tO\nlet\tO\nme\tO\nconnect\tO\nto\tO\nmy\tO\nWifi\tO\nsystem\tO\nwhere\tO\nI\tO\nlived\tO\n.\tO\n\nNot\tO\ntoo\tO\nmuch\tO\n\"\tO\njunk\tO\n\"\tO\nsoftware\tB-aspectTerm\nto\tO\nremove\tO\n.\tO\n\nSystem\tB-aspectTerm\nis\tO\nloosing\tO\nabout\tO\n20\tO\n%\tO\nof\tO\nperformance\tB-aspectTerm\nbecause\tO\nof\tO\nthat\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\ngood\tO\nquality\tB-aspectTerm\nand\tO\ngood\tO\nprice\tB-aspectTerm\n.\tO\n\nThe\tO\ndifference\tO\nin\tO\nthe\tO\nApple\tB-aspectTerm\nkeyboard\tI-aspectTerm\nfrom\tO\na\tO\nPC\tB-aspectTerm\n's\tI-aspectTerm\nkeyboard\tI-aspectTerm\ntook\tO\na\tO\nbit\tO\nof\tO\ntim\tO\nto\tO\nget\tO\nused\tO\nto\tO\n,\tO\nbut\tO\noverall\tO\nit\tO\n's\tO\nworth\tO\nit\tO\n!\tO\n\nIt\tO\nis\tO\nalso\tO\nextremely\tO\npleasing\tO\nto\tO\nthe\tO\neyes\tO\nwithout\tO\nlooking\tO\ntoo\tO\nmuch\tO\nlike\tO\nan\tO\nAlienware\tO\ngaming\tO\nmachine\tO\n.\tO\n\nThe\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\nfor\tO\nthe\tO\n$\tO\n4000\tO\nand\tO\nup\tO\ncomputers\tO\nwas\tO\nthe\tO\nonly\tO\none\tO\navailable\tO\nfor\tO\npurchase\tO\non\tO\nthe\tO\ndrop\tO\ndrown\tO\nmenu\tO\n.\tO\n\nOnly\tO\nissue\tO\nis\tO\nthat\tO\nit\tO\nis\tO\na\tO\nlittle\tO\nslow\tO\n,\tO\nand\tO\nI\tO\n'm\tO\nfixing\tO\nthat\tO\nby\tO\nadding\tO\nmore\tO\nRAM\tB-aspectTerm\n.\tO\n\nIt\tO\nis\tO\neasily\tO\nportable\tO\nand\tO\nI\tO\ntake\tO\nit\tO\neverywhere\tO\nI\tO\ngo\tO\nand\tO\nmight\tO\nrequire\tO\ninternet\tO\naccess\tO\n.\tO\n\nIf\tO\nI\tO\nhave\tO\na\tO\nfew\tO\nhundred\tO\ndollars\tO\nto\tO\nspare\tO\n,\tO\nI\tO\n'd\tO\nbuy\tO\nthe\tO\nPro\tO\nline\tO\nthough\tO\n,\tO\nthe\tO\n2.53\tO\nand\tO\n2.66\tO\nGHz\tO\nmodel\tO\n.\tO\n\nThe\tO\nhard\tO\ndrive\tB-aspectTerm\ncrashed\tI-aspectTerm\nas\tO\nwell\tO\n,\tO\nand\tO\nI\tO\nhad\tO\nto\tO\nbuy\tO\na\tO\nnew\tO\npower\tO\ncord\tB-aspectTerm\n.\tI-aspectTerm\n\nBut\tO\nenough\tO\nabout\tO\nthat\tO\n,\tO\nI\tO\nam\tO\nan\tO\nApple\tO\nconvert\tO\nfor\tO\nlife\tO\n.\tO\n\nI\tO\nlove\tO\nit\tO\nand\tO\nwill\tO\nprobably\tO\nget\tO\nanother\tO\none\tO\nwhen\tO\nthis\tO\ngoes\tO\nto\tO\nthe\tO\nLaptop\tO\nin\tO\nthe\tO\nsky\tO\n!\tO\n!\tO\n\nBut\tO\n,\tO\nMac\tO\nmakes\tO\nthe\tO\nswitch\tO\nfrom\tO\nPC\tO\nto\tO\nMac\tO\neasy\tO\n.\tO\n\nAnother\tO\nissue\tO\nI\tO\nhave\tO\nwith\tO\nit\tO\nis\tO\nthe\tO\nbattery\tB-aspectTerm\n.\tO\n\nHELP\tO\n,\tO\nHELP\tO\n,\tO\nOTHER\tO\nTHAN\tO\nTHAT\tO\nGETS\tO\nA\tO\nGREAT\tO\nLITTLE\tO\nWONDER\tO\n.\tO\n\nNow\tO\nI\tO\nknow\tO\n!\tO\n\nAfter\tO\n2\tO\nmonths\tO\nof\tO\ncomplaints\tO\n,\tO\nAsus\tO\nfinally\tO\nsent\tO\nthe\tO\nright\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nto\tO\nmy\tO\ntechies\tB-aspectTerm\n.\tO\n\nEven\tO\nset\tO\nat\tO\nthe\tO\nhighest\tO\nlevel\tO\n,\tO\nthe\tO\ncomputer\tO\nsacrifices\tO\nits\tO\nqueen\tO\nevery\tO\ntime\tO\n.\tO\n\nThat\tO\nincluded\tO\nthe\tO\nextra\tO\nSony\tB-aspectTerm\nSonic\tI-aspectTerm\nStage\tI-aspectTerm\nsoftware\tI-aspectTerm\n,\tO\nthe\tO\nspeakers\tB-aspectTerm\nand\tO\nthe\tO\nsubwoofer\tB-aspectTerm\nI\tO\ngot\tO\n(\tO\nthat\tO\nWAS\tO\nworth\tO\nthe\tO\nmoney\tO\n)\tO\n,\tO\nthe\tO\nbluetooth\tB-aspectTerm\nmouse\tI-aspectTerm\nfor\tO\nmy\tO\nsupposedly\tO\nbluetooth\tB-aspectTerm\nenabled\tI-aspectTerm\ncomputer\tO\n,\tO\nthe\tO\nextended\tB-aspectTerm\nlife\tI-aspectTerm\nbattery\tI-aspectTerm\nand\tO\nthe\tO\nDocking\tB-aspectTerm\nport\tI-aspectTerm\n.\tO\n\nMy\tO\nMacBook\tO\nPro\tO\nworks\tB-aspectTerm\nlike\tO\na\tO\ndream\tO\n,\tO\nit\tO\nhas\tO\nnever\tO\noverheated\tO\n,\tO\nor\tO\neven\tO\nbeen\tO\nslightly\tO\nwarm\tO\nfor\tO\nthat\tO\nmatter\tO\n.\tO\n\nPC\tO\nusers\tO\nuse\tO\nthe\tO\nPowerpoint\tB-aspectTerm\nprogram\tI-aspectTerm\nfor\tO\nslide\tO\n-\tO\nshow\tO\npresentation\tO\nand\tO\nMac\tO\nusers\tO\nutilize\tO\nKeynote\tB-aspectTerm\n.\tO\n\nI\tO\nca\tO\nn't\tO\nbegin\tO\nto\tO\nsay\tO\nhow\tO\ndisappointed\tO\nI\tO\nam\tO\n.\tO\n\nI\tO\nget\tO\na\tO\nton\tO\nof\tO\ncompliments\tO\non\tO\nits\tO\nsize\tB-aspectTerm\n,\tO\nand\tO\nspeaking\tO\nas\tO\nsomeone\tO\nwho\tO\nregularly\tO\ncommutes\tO\non\tO\na\tO\nbus\tO\n,\tO\nI\tO\ncan\tO\nattest\tO\nto\tO\nthe\tO\nfact\tO\nthat\tO\nthis\tO\nis\tO\nthe\tO\nperfect\tO\nsize\tB-aspectTerm\ncomputer\tO\nif\tO\nyou\tO\n're\tO\nrestricted\tO\nto\tO\nthe\tO\nwidth\tO\nof\tO\nyour\tO\nbody\tO\nfor\tO\ncomputing\tO\nroom\tO\n.\tO\n\nIt\tO\ntakes\tO\nme\tO\napproximately\tO\n3\tO\ntries\tO\nto\tO\nget\tO\nto\tO\neach\tO\nsite\tO\n,\tO\nthen\tO\nafter\tO\nclosing\tO\nthe\tO\nbrowser\tB-aspectTerm\nand\tO\nreopening\tO\nit\tO\nit\tO\nactually\tO\nworks\tO\n.\tO\n\nEasy\tO\nto\tO\ncarry\tB-aspectTerm\n,\tO\ncan\tO\nbe\tO\ntaken\tO\nanywhere\tO\n,\tO\ncan\tO\nbe\tO\nhooked\tO\nup\tO\nto\tO\nprinters\tO\n,\tO\nheadsets\tO\n.\tO\n\nalso\tO\nthe\tO\nkeyboard\tB-aspectTerm\ndoes\tO\nnot\tO\nliht\tO\nup\tO\nso\tO\nunless\tO\nyour\tO\nsitting\tO\nin\tO\na\tO\nroom\tO\nwith\tO\nsome\tO\nlight\tO\nyou\tO\nca\tO\nnt\tO\nsee\tO\nanything\tO\nand\tO\nthat\tO\ns\tO\nbad\tO\nfor\tO\nme\tO\nbecause\tO\nmy\tO\nboyfriend\tO\ntends\tO\nto\tO\nwatch\tO\ntv\tO\nin\tO\nthe\tO\ndark\tO\nat\tO\nnight\tO\nwhich\tO\nleaves\tO\nme\tO\nwith\tO\nno\tO\nway\tO\nof\tO\nseeing\tO\nthe\tO\nkeyboard\tB-aspectTerm\n.\tO\n\nTake\tO\nthe\tO\nsimple\tO\n,\tO\neasy\tO\nsolution\tO\nto\tO\nyour\tO\ncomputer\tO\nproblems\tO\nand\tO\nstop\tO\nwaiting\tO\nand\tO\nsmacking\tO\nyour\tO\nold\tO\ncomputer\tO\naround\tO\n.\tO\n\nIt\tO\nis\tO\nas\tO\ngood\tO\nas\tO\nnew\tO\n.\tO\n\nAnd\tO\nit\tO\ndid\tO\nn't\tO\nshow\tO\nup\tO\non\tO\nthe\tO\nreciept\tO\n,\tO\nI\tO\ndo\tO\nn't\tO\nknow\tO\nhow\tO\nwe\tO\nordered\tO\nit\tO\nonline\tO\n!\tO\n\nI\tO\nwent\tO\nfrom\tO\nBestBuy\tO\nto\tO\nDell\tO\n,\tO\nWindows\tO\nto\tO\nApple\tO\n.\tO\n\nBack\tO\nthen\tO\nmy\tO\nentire\tO\nfamily\tO\nwas\tO\nDevoted\tO\nto\tO\nthe\tO\nSony\tO\nname\tO\n.\tO\n\nWhen\tO\nI\tO\ngot\tO\nmy\tO\nlaptop\tO\nback\tO\nafter\tO\nthis\tO\nfirst\tO\ninstance\tO\nit\tO\nworked\tO\nokay\tO\nfor\tO\na\tO\nlittle\tO\nbit\tO\nthen\tO\nI\tO\nstarted\tO\nexpeirencing\tO\nissues\tO\nagain\tO\n,\tO\neverything\tO\nfrom\tO\nprograms\tB-aspectTerm\nand\tO\ndrivers\tB-aspectTerm\nfailing\tO\nagain\tO\n,\tO\nto\tO\nit\tO\npowering\tO\noff\tO\nfor\tO\nno\tO\nreason\tO\n,\tO\nto\tO\nlocking\tO\nup\tO\nand\tO\nfreezing\tO\nand\tO\njust\tO\nall\tO\nsorts\tO\nof\tO\nissues\tO\n.\tO\n\nLove\tO\nthat\tO\nit\tO\ndoes\tO\nn't\tO\ntake\tO\nup\tO\nspace\tB-aspectTerm\nlike\tO\na\tO\nregular\tO\ncomputer\tO\n.\tO\n\n*\tO\n3\tO\nweeks\tO\nafter\tO\ngiving\tO\nthe\tO\ncomputer\tO\nfor\tO\nrepair*-Visited\tO\nMacHouse\tO\nAmsterdam\tO\n.\tO\n\nThey\tO\ndo\tO\nn't\tO\nseem\tO\nto\tO\nbe\tO\nsusceptible\tO\nto\tO\nviruses\tO\n,\tO\nwhich\tO\nis\tO\none\tO\nless\tO\nbig\tO\nthing\tO\nto\tO\nworry\tO\nabout\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\ncomputers\tO\n.\tO\n\nI\tO\nwas\tO\nvery\tO\nexcited\tO\nbecause\tO\nthis\tO\nwas\tO\nmy\tO\nfirst\tO\npersonal\tO\ncomputer\tO\nand\tO\nI\tO\nwas\tO\npurchasing\tO\nit\tO\nwith\tO\nmy\tO\nOWN\tO\nmoney\tO\nI\tO\nhad\tO\nrecieved\tO\nfrom\tO\ngraduation\tO\npresents\tO\n.\tO\n\nAsked\tO\nthe\tO\ncustomer\tB-aspectTerm\nservice\tI-aspectTerm\nrep\tI-aspectTerm\n.\tO\n\nSo\tO\n,\tO\nI\tO\ntook\tO\nit\tO\nback\tO\nto\tO\nthe\tO\napple\tO\nstore\tO\nand\tO\nthey\tO\nnarcissist\tO\ngenius\tB-aspectTerm\nbar\tI-aspectTerm\nstaff\tI-aspectTerm\n)\tO\nfixed\tO\nit\tO\nby\tO\nresetting\tO\nthe\tO\nfan\tB-aspectTerm\nat\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\n.\tO\n\nI\tO\ncan\tO\nnot\tO\neven\tO\nimaging\tO\ngoing\tO\nback\tO\nto\tO\na\tO\nPC\tO\nafter\tO\nusing\tO\nthis\tO\nwonderful\tO\ncomputer\tO\n.\tO\n\nBasic\tO\ncomputer\tO\n.\tO\n\nI\tO\nfell\tO\nin\tO\nlove\tO\nwith\tO\nthe\tO\nhp\tO\npavillion\tO\nand\tO\nthat\tO\nwas\tO\nmy\tO\nreplacement\tO\nand\tO\nnow\tO\nI\tO\ncould\tO\nnot\tO\nimagine\tO\ngoing\tO\nback\tO\nto\tO\nan\tO\nacer\tO\nat\tO\nall\tO\n.\tO\n\nIt\tO\nturns\tO\nout\tO\nthat\tO\nthis\tO\nhp\tO\npc\tO\nhad\tO\nbeen\tO\npreciously\tO\nsold\tO\nby\tO\nWal\tO\nMart\tO\n.\tO\n\nI\tO\nwould\tO\ntotally\tO\nrecommend\tO\nany\tO\nother\tO\nlaptop\tO\nover\tO\nthis\tO\npile\tO\nof\tO\ngrabage\tO\n.\tO\n\nI\tO\nmanaged\tO\nto\tO\ncomply\tO\nwith\tO\nthese\tO\ntoo\tO\nand\tO\nnow\tO\nhave\tO\nto\tO\nwait\tO\nand\tO\nsee\tO\nif\tO\nthey\tO\ncan\tO\nfind\tO\nanother\tO\nway\tO\nto\tO\nscrew\tO\nme\tO\n.\tO\n\nI\tO\nshould\tO\nhave\tO\nbought\tO\none\tO\na\tO\nlong\tO\ntime\tO\nago\tO\n.\tO\n\nI\tO\nlooked\tO\nat\tO\nthe\tO\ncomputer\tO\nand\tO\nit\tO\nsaid\tO\nupdating\tO\nbut\tO\nthe\tO\nasked\tO\nfor\tO\na\tO\nproduct\tO\nkey\tO\n.\tO\n\nI\tO\ngot\tO\nwhat\tO\nI\tO\npaid\tO\nfor\tO\n.\tO\n\nJust\tO\nkeep\tO\nin\tO\nmind\tO\nthe\tO\ngraphics\tB-aspectTerm\nis\tO\nnot\tO\ndedicated\tO\nso\tO\nloading\tO\nthe\tO\nmovie\tO\nalmost\tO\ntook\tO\na\tO\nminute\tO\n,\tO\nbut\tO\nit\tO\nran\tO\nfairly\tO\nsmooth\tO\nfor\tO\na\tO\nnon\tB-aspectTerm\n-\tI-aspectTerm\ndedicated\tI-aspectTerm\ngraphics\tI-aspectTerm\ncard\tI-aspectTerm\n.\tO\n\nNeeds\tO\nPower\tO\nand\tO\nMouse\tB-aspectTerm\nCable\tI-aspectTerm\nto\tO\nPlug\tO\nin\tO\nback\tO\ninstead\tO\nof\tO\nside\tO\n,\tO\nIn\tO\nthe\tO\nway\tO\nof\tO\noperating\tO\na\tO\nmouse\tB-aspectTerm\nin\tO\nsmall\tO\narea\tO\n.\tO\n\nHowever\tO\nI\tO\ndealt\tO\nwith\tO\nthis\tO\nproblem\tO\nfor\tO\nover\tO\na\tO\nyear\tO\nand\tO\nit\tO\nwas\tO\nmore\tO\nof\tO\na\tO\nhastle\tO\nthen\tO\nI\tO\nhave\tO\nEVER\tO\nhad\tO\nwith\tO\nanything\tO\n.\tO\n\nI\tO\ngot\tO\nthe\tO\nfirst\tO\n\"\tO\nBlue\tO\nscreen\tO\nof\tO\ndeath\tO\n\"\tO\nin\tO\nthe\tO\nearly\tO\npart\tO\nof\tO\nJuly\tO\n.\tO\n\n-4\tO\nRAM\tB-aspectTerm\nslots\tI-aspectTerm\n,\tO\n2\tO\nHDD\tB-aspectTerm\nBays\tI-aspectTerm\n*\tO\n,\tO\n16\tB-aspectTerm\nGB\tI-aspectTerm\nRAM\tI-aspectTerm\nsupport\tI-aspectTerm\n-No\tO\nWireless\tB-aspectTerm\nIssues\tO\n,\tO\nat\tO\nleast\tO\nfor\tO\nme\tO\n.\tO\n\nI\tO\nagree\tO\nwith\tO\nthe\tO\nprevious\tO\ncomment\tO\nthat\tO\nASUS\tB-aspectTerm\nTECH\tI-aspectTerm\nSUPPORT\tI-aspectTerm\nIS\tO\nHORRIBLE\tO\nWHICH\tO\nIS\tO\nA\tO\nCON\tO\nIN\tO\nMY\tO\nOPINION\tO\n.\tO\n\nIn\tO\nfact\tO\n,\tO\nsomehow\tO\n(\tO\nand\tO\nI\tO\nnever\tO\nopened\tO\nit\tO\nup\tO\n)\tO\nsome\tO\nspecks\tO\nof\tO\ndust\tO\nor\tO\nsomething\tO\ngot\tO\ninside\tO\nthe\tO\nscreen\tB-aspectTerm\nand\tO\nare\tO\nnow\tO\nthere\tO\npermanently\tO\n,\tO\nbehind\tO\nthe\tO\nfront\tO\nof\tO\nthe\tO\nscreen\tB-aspectTerm\n,\tO\nin\tO\nthe\tO\nway\tO\nof\tO\nthe\tO\ndisplay\tB-aspectTerm\n.\tO\n\nIt\tO\nseems\tO\nto\tO\nbe\tO\nincompatible\tO\nwith\tO\neverything\tO\nelse\tO\n.\tO\n\nthe\tO\nmouse\tB-aspectTerm\non\tI-aspectTerm\nthe\tI-aspectTerm\npad\tI-aspectTerm\n,\tO\nthe\tO\nleft\tB-aspectTerm\nbutton\tI-aspectTerm\nalways\tO\nsticks\tO\n.\tO\n\nWhen\tO\nI\tO\ntook\tO\nit\tO\nback\tO\nto\tO\nBest\tO\nBuy\tO\nI\tO\nasked\tO\nthem\tO\nif\tO\nthey\tO\nwere\tO\nseriously\tO\ntrying\tO\nto\tO\ndrive\tO\nme\tO\ninsane\tO\n!\tO\n\ni\tO\nhave\tO\ntried\tO\nto\tO\ncharge\tO\non\tO\ndifferent\tO\nbatteries\tO\nwith\tB-aspectTerm\nno\tO\nluck\tO\n.\tO\n\nI\tO\nwould\tO\nrecommend\tO\nthis\tO\ncomputer\tO\nto\tO\nanyone\tO\nsearching\tO\nfor\tO\nthe\tO\nperfect\tO\nlaptop\tO\n,\tO\nand\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\namazing\tO\n.\tO\n\nWe\tO\nuse\tO\nthe\tO\nbuilt\tB-aspectTerm\nin\tI-aspectTerm\ntools\tI-aspectTerm\noften\tO\n,\tO\niTunes\tB-aspectTerm\nis\tO\nopen\tO\nnearly\tO\nevery\tO\nday\tO\nand\tO\nworks\tO\ngreat\tO\nwith\tO\nmy\tO\niPhone\tO\n.\tO\n\nBut\tO\nmy\tO\nblog\tO\nis\tO\nread\tO\nby\tO\nmy\tO\nfriends\tO\nand\tO\nsearch\tO\nengine\tO\nvisitors\tO\n.\tO\n\nIt\tO\nwas\tO\nreturned\tO\non\tO\nthe\tO\nthird\tO\nday\tO\nI\tO\nowned\tO\nit\tO\n.\tO\n\nIT\tO\nWANT\tO\nTAKE\tO\nIT\tO\n,\tO\nIT\tO\nKEEP\tO\nSAYING\tO\nERROR\tO\n.\tO\n\nAnyone\tO\nwho\tO\nis\tO\nconsidering\tO\nbuying\tO\nan\tO\nAcer\tO\ncomputer\tO\nof\tO\nany\tO\nsort\tO\n,\tO\nI\tO\nseriously\tO\nsuggest\tO\nyou\tO\nlook\tO\ninto\tO\nbuying\tO\na\tO\ndifferent\tO\nbrand\tO\n.\tO\n\nthe\tO\nsize\tB-aspectTerm\nof\tO\nhas\tO\nactually\tO\nhelp\tO\nme\tO\nout\tO\nquite\tO\na\tO\nbit\tO\nby\tO\nme\tO\nbeing\tO\nable\tO\nto\tO\nfit\tO\nit\tO\nin\tO\nan\tO\nalready\tO\nfull\tO\nbackpack\tO\nand\tO\nto\tO\nuse\tO\nit\tO\nat\tO\na\tO\nresturant\tO\nwhere\tO\nthe\tO\nfood\tO\non\tO\nthe\tO\ntable\tO\nis\tO\nalways\tO\nso\tO\nspace\tO\nconsuming\tO\n.\tO\n\nHighly\tO\nrecommend\tO\nfor\tO\ndaily\tO\nuse\tO\n.\tO\n\nWe\tO\nare\tO\naddicted\tO\nto\tO\nthe\tO\nMac\tO\n.\tO\n\nBecause\tO\nit\tO\nIS\tO\na\tO\ndefective\tO\nproduct\tO\n.\tO\n\nSecond\tO\n,\tO\nit\tO\ngets\tO\nscratches\tO\neasily\tO\nand\tO\nwhen\tO\nit\tO\ngets\tO\nold\tO\nsome\tO\nthing\tO\nmay\tO\noperated\tO\n\nTrue\tO\nquality\tB-aspectTerm\nat\tO\na\tO\ngreat\tO\nprice\tB-aspectTerm\n!\tO\n\nNot\tO\neasy\tO\nto\tO\ncarry\tB-aspectTerm\n.\tO\n\nThe\tO\nprograms\tB-aspectTerm\nthat\tO\ncome\tO\nstandard\tO\nwith\tO\nthe\tO\nLeopard\tB-aspectTerm\nrunning\tI-aspectTerm\nsystem\tI-aspectTerm\nare\tO\nenough\tO\nfor\tO\nthe\tO\naverage\tO\nperson\tO\nto\tO\nrun\tO\nall\tO\nthe\tO\nbasics\tO\n.\tO\n\nI\tO\nam\tO\nreally\tO\nheartbroken\tO\nto\tO\nhave\tO\nto\tO\npost\tO\na\tO\nterrible\tO\nreview\tO\n.\tO\n\nSo\tO\nwhat\tO\nam\tO\nI\tO\nsupposed\tO\nto\tO\ndo\tO\n?\tO\nThe\tO\nLG\tO\nservice\tB-aspectTerm\ncenter\tI-aspectTerm\ncan\tO\nnot\tO\nprovide\tO\nme\tO\nthe\tO\n\"\tO\nservice\tO\n\"\tB-aspectTerm\nwhen\tO\nit\tO\nis\tO\ncalled\tO\nthe\tO\n\"\tO\nservice\tO\ncenter\tB-aspectTerm\n\"\tI-aspectTerm\n.\tO\n\nThe\tO\nMaterial\tB-aspectTerm\nthis\tO\nPro\tO\nis\tO\nmade\tO\nout\tO\nof\tO\nseems\tO\na\tO\nlot\tO\nnicer\tO\nthan\tO\nany\tO\nPC\tO\nSpecs\tO\n:\tB-aspectTerm\nLike\tO\nI\tO\nsaid\tO\nthis\tO\nperforms\tO\na\tO\nlot\tO\nbetter\tO\nthan\tO\nany\tO\ncomputer\tO\nI\tO\n've\tO\nhad\tO\nin\tO\nthe\tO\npast\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nnothing\tO\nbut\tO\ntrouble\tO\nfrom\tO\nthe\tO\ntime\tO\nwe\tO\nbought\tO\nit\tO\n.\tO\n\nAfter\tO\ndoing\tO\nextensive\tO\nresearch\tO\n,\tO\nmacconnection\tO\nhad\tO\nthe\tO\nlowest\tO\nprice\tB-aspectTerm\non\tO\nthe\tO\n15\tO\n\"\tO\nMBP\tO\ni5\tO\n.\tO\n\nI\tO\nam\tO\nADDICTED\tO\nto\tO\nphoto\tB-aspectTerm\nbooth\tI-aspectTerm\n!\tO\n\nThe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nand\tO\nuser\tB-aspectTerm\ninterface\tI-aspectTerm\nis\tO\nvery\tO\nintuitive\tO\n,\tO\nand\tO\nthe\tO\nlarge\tO\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\ntrack\tI-aspectTerm\npad\tI-aspectTerm\nis\tO\namazing\tO\n.\tO\n\nSo\tO\n,\tO\nI\tO\nwent\tO\nback\tO\n.\tO\n\nI\tO\nlike\tO\nit\tO\nso\tO\nmuch\tO\n,\tO\nI\tO\nbought\tO\nanother\tO\njust\tO\nfor\tO\nmy\tO\nwife\tO\n.\tO\n\nI\tO\ntook\tO\nit\tO\nback\tO\nto\tO\nthe\tO\nstore\tO\nand\tO\nexchanged\tO\nit\tO\nfor\tO\nanother\tO\none\tO\n.\tO\n\nAll\tO\nin\tO\nall\tO\ngreat\tO\nitem\tO\nhighly\tO\nrecommend\tO\nit\tO\n.\tO\n\nHard\tB-aspectTerm\ndisk\tI-aspectTerm\n-\tO\nThe\tO\nnew\tO\neditions\tO\ngives\tO\nyou\tO\nmore\tO\nhard\tB-aspectTerm\ndisk\tI-aspectTerm\nspace\tI-aspectTerm\n(\tO\n500\tO\nGB\tO\ninstead\tO\nof\tO\n320\tO\nGB\tO\n)\tO\nbut\tO\ntime\tO\nhas\tO\ntaught\tO\nme\tO\nnever\tO\nto\tO\ntrust\tO\nan\tO\ninternal\tB-aspectTerm\nhard\tI-aspectTerm\ndisk\tI-aspectTerm\n.\tO\n\nThis\tO\nlaptop\tO\nrocks\tO\n(\tO\nonly\tO\nwish\tO\nit\tO\ncould\tO\nrun\tO\nSolidWorks\tO\nCAD\tO\n-\tO\nwhich\tO\nApple\tO\ndoes\tO\nn't\tO\nsupport\tO\n)\tO\n!\tO\n\nIt\tO\nis\tO\nextremely\tO\nportable\tO\nand\tO\neasily\tO\nconnects\tB-aspectTerm\nto\tI-aspectTerm\nWIFI\tI-aspectTerm\nat\tO\nthe\tO\nlibrary\tO\nand\tO\nelsewhere\tO\n.\tO\n\nI\tO\ndo\tO\nn't\tO\nhave\tO\nthat\tO\nadditional\tO\nmoney\tO\nright\tO\nnow\tO\n,\tO\nand\tO\ntherefore\tO\nwould\tO\nn't\tO\nhave\tO\npurchased\tO\nit\tO\nat\tO\nthis\tO\ntime\tO\n.\tO\n\nFirst\tO\nthings\tO\nfirst\tO\n,\tO\nMacbook\tO\npro\tO\nhas\tO\nmany\tO\napplications\tB-aspectTerm\nto\tO\nmake\tO\nlife\tO\neasier\tO\n,\tO\nunlike\tO\nthe\tO\nwindows\tB-aspectTerm\ncomputers\tO\n.\tO\n\nAnd\tO\nthe\tO\nscreen\tB-aspectTerm\non\tO\nthis\tO\nthing\tO\nis\tO\nabsolutely\tO\namazing\tO\nfor\tO\nhigh\tO\nquality\tO\nvideos\tO\nand\tO\nmovies\tO\nand\tO\ngaming\tB-aspectTerm\n.\tO\n\nFast\tO\n,\tO\nfast\tO\nand\tO\nfast\tO\n,\tO\nthe\tO\nweb\tO\npages\tO\njust\tO\nfly\tO\nby\tO\n.\tO\n\nI\tO\nconsidered\tO\nI\tO\nmay\tO\nhave\tO\ntoo\tO\nmuch\tO\non\tO\nthe\tO\ncomputer\tO\n,\tO\nbut\tO\nafter\tO\nlooking\tO\n,\tO\nthere\tO\nwas\tO\nplenty\tO\nof\tO\nspace\tO\nand\tB-aspectTerm\nthat\tO\nis\tO\nnot\tO\nthe\tO\nissue\tO\n.\tO\n\nI\tO\ndo\tO\nn't\tO\nuse\tO\nmy\tO\nlaptop\tO\nin\tO\na\tO\nway\tO\nthough\tO\nthat\tO\nneeds\tO\na\tO\nlong\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nso\tO\nit\tO\n's\tO\nperfect\tO\nfor\tO\nme\tO\n.\tO\n\nGuess\tO\nI\tO\n'll\tO\nstay\tO\naway\tO\nfrom\tO\nHP\tO\n.\tO\n\nIt\tO\nis\tO\nmade\tO\nbetter\tO\n,\tO\nthicker\tO\n,\tO\nand\tO\nall\tO\nout\tO\ntough\tO\n!\tO\n\nIt\tO\nwas\tO\nabout\tO\nsix\tO\nmonths\tO\nlater\tO\nwhen\tO\nthe\tO\noverheating\tO\nproblem\tO\nstarted\tO\nagain\tO\n,\tO\nto\tO\nthe\tO\npoint\tO\nit\tO\nfelt\tO\nlike\tO\nfire\tO\non\tO\nthe\tO\nbottom\tO\nof\tO\nthe\tO\nmachine\tO\n!\tO\n\nThere\tO\nis\tO\na\tO\nblank\tO\nlighted\tO\nscreen\tO\nwhen\tO\nI\tO\nstart\tO\nand\tO\nthat\tO\nis\tO\nall\tO\n.\tO\n\nAnd\tO\ni\tO\nwould\tO\nrecommend\tO\nthis\tO\nto\tO\nanypne\tO\nlooking\tO\nfor\tO\na\tO\nnew\tO\nlaptop\tO\n.\tO\n\nBut\tO\nthen\tO\n,\tO\nsomething\tO\ngoes\tO\nwrong\tO\n.\tO\n\nSo\tO\nfar\tO\nso\tO\ngood\tO\nwith\tO\nthis\tO\nlaptop\tO\n.\tO\n\ni\tO\nmust\tO\nkeep\tO\nit\tO\nplugged\tO\nin\tO\nat\tO\nall\tO\ntimes\tO\nbecause\tO\nit\tO\nwill\tO\nnot\tO\nkeep\tO\na\tO\ncharge\tO\nfor\tB-aspectTerm\nlonger\tO\nthan\tO\nfour\tO\nminutes\tO\n.\tO\n\nAvoid\tO\nthis\tO\nmodel\tO\n.\tO\n\nSummary\tO\n:\tO\nI\tO\n've\tO\nhad\tO\nthis\tO\nlaptop\tO\nfor\tO\n2\tO\nmonths\tO\n,\tO\nout\tO\nof\tO\nthe\tO\nblue\tO\nthe\tO\npower\tB-aspectTerm\nadapter\tI-aspectTerm\nstops\tO\nworking\tO\n.\tO\n\nI\tO\nsaw\tO\nwalmart\tO\nhad\tO\nthe\tO\nsame\tO\ncomputer\tO\nfor\tO\nabout\tO\n$\tO\n650\tO\nbut\tO\nstill\tO\nknowing\tO\nwhat\tO\nI\tO\nknow\tO\nnow\tO\n,\tO\nI\tO\nwould\tO\nnot\tO\nbuy\tO\nit\tO\nat\tO\nthat\tO\nprice\tB-aspectTerm\n.\tO\n\nThe\tO\nlocal\tO\ncomputer\tO\nrepair\tO\nshops\tO\nsend\tO\nout\tO\nads\tO\nthat\tO\nsay\tO\nalong\tO\nthe\tO\nlines\tO\nof\tO\nwe\tO\ncan\tO\nfix\tO\nalmost\tO\nany\tO\nproblem\tO\nor\tO\ncomputer\tO\nusually\tO\neven\tO\nthe\tO\ntrouble\tO\nsome\tO\nToshiba\tO\nsatellite\tO\n.\tO\n\nit\tO\nhas\tO\nhad\tO\nsome\tO\nproblems\tO\n.\tO\n\nThere\tO\ns\tO\nalways\tO\nsomething\tO\nwrong\tO\nwith\tO\nit\tO\n,\tO\nwether\tO\nit\tO\nbe\tO\nsome\tO\nvirus\tO\nyou\tO\nca\tO\nn't\tO\ntrack\tO\ndown\tO\n,\tO\nor\tO\nit\tO\noverheats\tO\n,\tO\nsometimes\tO\neven\tO\ncatches\tO\non\tO\nfire\tO\n,\tO\nyou\tO\njust\tO\nca\tO\nn't\tO\nuse\tO\nit\tO\n.\tO\n\nThis\tO\ncomputer\tO\nis\tO\ngood\tO\nfor\tO\n10\tO\ndays\tO\nthen\tO\nit\tO\nsucks\tO\nfor\tO\nthe\tO\nrest\tO\nof\tO\nyour\tO\nlife\tO\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nfor\tO\na\tO\nstudent\tO\n,\tO\nweight\tB-aspectTerm\nis\tO\nalways\tO\nan\tO\nissue\tO\n.\tO\n\nNow\tO\nmainboard\tB-aspectTerm\nis\tO\nbroken\tO\n,\tO\nhave\tO\nto\tO\nwait\tO\nfor\tO\na\tO\nnew\tO\none\tO\n.\tO\n\nThe\tO\nspeed\tB-aspectTerm\ndifference\tO\nis\tO\nnext\tO\nto\tO\nNOTHING\tO\nfor\tO\na\tO\nmac\tO\n,\tO\nand\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\ncan\tO\nbe\tO\nmanually\tO\nupgraded\tO\nor\tO\nyou\tO\ncould\tO\njust\tO\nbuy\tO\na\tO\n$\tO\n60\tO\n500\tB-aspectTerm\ngb\tI-aspectTerm\nexternal\tI-aspectTerm\nhard\tI-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\n2.The\tO\nwireless\tB-aspectTerm\ncard\tI-aspectTerm\nis\tO\nlow\tO\nquality\tO\n.\tO\n\nThis\tO\nlittle\tO\nnetboook\tO\nis\tO\nhelping\tO\nme\tO\nget\tO\nwork\tO\ndone\tO\n!\tO\n\nThey\tO\nalso\tO\nuse\tO\ntwo\tO\ntotally\tO\ndifferent\tO\noperating\tB-aspectTerm\nsystems\tI-aspectTerm\n.\tO\n\nThey\tO\nare\tO\nabout\tO\nthe\tO\nsame\tO\nsize\tO\nkeys\tB-aspectTerm\n.\tO\n\nI\tO\n'm\tO\ndefinitely\tO\nnot\tO\nhard\tO\non\tO\nlaptops\tO\nand\tO\nguarantee\tO\n100\tO\n%\tO\nthat\tO\nno\tO\nliquid\tO\nhas\tO\ntouched\tO\nthis\tO\nmachine\tO\nin\tO\nmy\tO\npresence\tO\n.\tO\n\nI\tO\nwaited\tO\nanother\tO\nmonth\tO\nfor\tO\napproval\tO\nand\tO\nfor\tO\nthem\tO\nto\tO\n\"\tO\nBUILD\tO\n\"\tO\nme\tO\na\tO\nnew\tO\nlaptop\tO\n.\tO\n\nThis\tO\nai\tO\nn't\tO\nit\tO\n.\tO\n\nI\tO\nwas\tO\nn't\tO\nreally\tO\nas\tO\nconcerned\tO\nabout\tO\nportability\tB-aspectTerm\n(\tO\nit\tO\n's\tO\na\tO\nvery\tO\nlarge\tO\nlaptop\tO\n)\tO\nbut\tO\nit\tO\n's\tO\nnot\tO\nhard\tO\nto\tO\nmove\tO\naround\tO\nor\tO\ntake\tO\non\tO\na\tO\ntrip\tO\nwhich\tO\nwas\tO\na\tO\npleasant\tO\nsurprise\tO\n.\tO\n\nThe\tO\npeople\tO\nare\tO\nfrustrating\tO\nto\tO\nwork\tO\nwith\tO\n,\tO\nthe\tO\nproduct\tO\nitself\tO\nis\tO\nvery\tO\ncheaply\tO\nmade\tO\n,\tO\nand\tO\nthe\tO\naccessories\tB-aspectTerm\nare\tO\nless\tO\nthan\tO\nsatisfactory\tO\n.\tO\n\nThey\tO\noffer\tO\nthe\tO\nbest\tO\nwarranty\tB-aspectTerm\nin\tO\nthe\tO\nbusiness\tO\n,\tO\nand\tO\ndo\tO\nn't\tO\n3rd\tO\nparty\tO\nit\tO\nout\tO\nlike\tO\nToshiba\tO\n.\tO\n\nMaybe\tO\nthree\tO\nor\tO\nfour\tO\nmonths\tO\nago\tO\nit\tO\nstarted\tO\nblinking\tO\nall\tO\nof\tO\nthe\tO\nsudden\tO\n.\tO\n\nThe\tO\nonly\tO\nproblems\tO\nare\tO\nthe\tO\nsound\tB-aspectTerm\nis\tO\nnt\tO\nvery\tO\nloud\tO\nI\tO\nhave\tO\nto\tO\nwear\tO\nheadphones\tO\n.\tO\n\nAgain-\tO\nwindows\tB-aspectTerm\nbased\tO\nmachines\tO\nwere\tO\nnot\tO\ngiving\tO\nme\tO\nanything\tO\nto\tO\nwork\tO\nwith\tO\n!\tO\n\nFinally\tO\n,\tO\nI\tO\ncould\tO\nn't\tO\ntake\tO\nit\tO\nanymore\tO\nand\tO\nordered\tO\nmy\tO\nApple\tO\n.\tO\n\nI\tO\nshould\tO\nhave\tO\nkept\tO\nmy\tO\nbig\tO\n,\tO\nold\tO\nHP\tO\n.\tO\n\neverything\tO\nabout\tO\na\tO\nmac\tO\nis\tO\nwonderful\tO\n,\tO\nit\tO\ntakes\tO\na\tO\nlittle\tO\nused\tO\nto\tO\nlearning\tO\nand\tO\ngetting\tO\nused\tO\nto\tO\nthe\tO\nnew\tO\nsystem\tB-aspectTerm\n,\tO\nbut\tO\nyou\tO\nwill\tO\nlearn\tO\nfast\tO\nand\tO\nits\tO\nall\tO\nworth\tO\nit\tO\n.\tO\n\ni\tO\nlove\tO\nthe\tO\nsize\tB-aspectTerm\nof\tO\nthe\tO\ncomputer\tO\nsince\tO\ni\tO\nplay\tO\ngames\tB-aspectTerm\non\tO\nit\tO\n.\tO\n\nI\tO\nam\tO\na\tO\nwife\tO\n,\tO\nmom\tO\nand\tO\na\tO\nschool\tO\nteacher\tO\nand\tO\na\tO\ncollege\tO\nstudent\tO\n.\tO\n\nYou\tO\nknow\tO\n,\tO\nusing\tO\nthe\tO\ncomputer\tO\nshould\tO\nbe\tO\nfun\tO\n,\tO\nnot\tO\naggrevation\tO\n,\tO\nespecially\tO\nwhen\tO\nyou\tO\nare\tO\nplaying\tB-aspectTerm\ngames\tI-aspectTerm\nor\tO\nworking\tO\nwith\tO\nphotos\tO\n.\tO\n\nYou\tO\njust\tO\nget\tO\na\tO\ntrial\tO\nversion\tO\neither\tO\nway\tO\n.\tO\n\nI\tO\n'm\tO\nall\tO\nfor\tO\nsaving\tO\nmoney\tO\nbut\tO\nDell\tO\nneeds\tO\nto\tO\nstep\tO\nit\tO\nup\tO\n.\tO\n\nThere\tO\nare\tO\nno\tO\nviruses\tO\nor\tO\nspyware\tO\nto\tO\nworry\tO\nabout\tO\nlike\tO\non\tO\na\tO\nWindows\tB-aspectTerm\ncomputer\tO\n.\tO\n\ngreat\tO\nmachine\tO\nif\tO\nyou\tO\nwant\tO\nto\tO\ndrop\tO\nthe\tO\ncash\tO\nfor\tO\none\tO\n.\tO\n\nTo\tO\nbe\tO\nhonest\tO\ni\tO\nthink\tO\nit\tO\nwas\tO\nfaulty\tO\nequipment\tB-aspectTerm\nor\tO\nsomething\tO\nbut\tO\nidk\tO\n.\tO\n\nI\tO\nalso\tO\nlove\tO\nthe\tO\nsmall\tO\n,\tO\nconvenient\tO\nsize\tB-aspectTerm\nof\tO\nmy\tO\nlaptop\tO\n,\tO\nmaking\tO\nit\tO\na\tO\nperfect\tO\ntool\tO\nfor\tO\nmy\tO\nacademic\tO\nstudies\tO\n.\tO\n\nI\tO\nnever\tO\nhave\tO\nhad\tO\na\tO\ngood\tO\nresult\tO\nwith\tO\nthis\tO\ncomputer\tO\n.\tO\n\nI\tO\nlove\tO\nits\tO\nsolid\tO\nbuild\tB-aspectTerm\n,\tO\nlight\tO\nwt\tB-aspectTerm\nand\tO\nexcellent\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n(\tO\nfor\tO\nnow\tO\n)\tO\n.\tO\n\nYOU\tO\nPAY\tO\nFOR\tO\nWHAT\tO\nYOU\tO\nGET\tO\nFOR\tO\n.\tO\n\nwhile\tO\nabout\tO\n8\tO\nyears\tO\nago\tO\n,\tO\nI\tO\nhope\tO\nthat\tO\nthe\tO\nquality\tB-aspectTerm\nhas\tO\nchanged\tO\n.\tO\n\nNO\tO\nmore\tO\nLenovo\tO\nfor\tO\nme\tO\n.\tO\n\nI\tO\nalso\tO\nbought\tO\none\tO\nfor\tO\nmy\tO\nwife\tO\n,\tO\nand\tO\n3\tO\nfor\tO\nmy\tO\noffice\tO\n.\tO\n\nHowever\tO\n,\tO\na\tO\nNETBOOK\tO\nwill\tO\nbe\tO\na\tO\ndifferent\tO\nstory\tO\n.\tO\n\nI\tO\n'm\tO\nglad\tO\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\n,\tO\nit\tO\nwas\tO\nworth\tO\nthe\tO\nfew\tO\n(\tO\n$\tO\n100\tO\n)\tO\nextra\tO\ndollars\tO\n.\tO\n\nThe\tO\ndifference\tO\nis\tO\nit\tO\n's\tO\na\tO\nwhole\tO\nlot\tO\nof\tO\nfun\tO\nusing\tO\nthe\tO\nlaptop\tO\nnow\tO\n,\tO\nstill\tO\nlearning\tO\nthe\tO\nApple\tB-aspectTerm\nnavigation\tI-aspectTerm\n,\tO\nbut\tO\nis\tO\nfun\tO\nand\tO\ncomes\tO\nwith\tO\na\tO\nlot\tO\nof\tO\ncool\tO\napps\tB-aspectTerm\n.\tO\n\nI\tO\nam\tO\na\tO\nfull\tO\nMac\tO\nconvert\tO\nnow\tO\n.\tO\n\nI\tO\nhighly\tO\nrecommend\tO\nthat\tO\nyou\tO\nbuy\tO\nthis\tO\nproduct\tO\n.\tO\n\nThough\tO\nyou\tO\nget\tO\na\tO\npolite\tO\nperson\tO\n,\tO\nyou\tO\noften\tO\ndon\tO\nt\tO\nget\tO\na\tO\nsolution\tO\n.\tO\n\n-I\tO\npropose\tO\nthat\tO\nI\tO\ncan\tO\njust\tO\nswap\tO\nthe\tO\nhard\tB-aspectTerm\ndrives\tI-aspectTerm\n.\tO\n\nIt\tO\nwas\tO\nold\tO\nbut\tO\nit\tO\nwas\tO\nnot\tO\ntill\tO\nwe\tO\nbought\tO\nthe\tO\nDell\tO\ndid\tO\nwe\tO\nrealize\tO\nhow\tO\ngreat\tO\nit\tO\nwas\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nholds\tO\nup\tO\nwell\tO\n,\tO\nit\tO\n's\tO\nbuilt\tB-aspectTerm\nvery\tO\nsolidly\tO\n,\tO\nand\tO\nruns\tB-aspectTerm\nfast\tO\n.\tO\n\nSound\tB-aspectTerm\ncard\tI-aspectTerm\nis\tO\nlimited\tO\nthough\tO\n.\tO\n\nI\tO\ninitially\tO\npurchased\tO\nmy\tO\nMacbook\tO\nPro\tO\n13\tO\n\"\tO\nin\tO\nApril\tO\n,\tO\nand\tO\nI\tO\nloved\tO\nit\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\nnicely\tO\nsized\tB-aspectTerm\nlaptop\tO\nwith\tO\nlots\tO\nof\tO\nprocessing\tB-aspectTerm\npower\tI-aspectTerm\nand\tO\nlong\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nAfter\tO\nmuch\tO\nbattling\tO\nwith\tO\nHP\tO\ni\tO\nwas\tO\nable\tO\nto\tO\nreturn\tO\nit\tO\n4\tO\ntimes\tO\nfor\tO\nrepairs\tO\n.\tO\n\nSo\tO\n,\tO\nyou\tO\ncan\tO\nimagine\tO\nhow\tO\nunhappy\tO\nI\tO\nam\tO\nwith\tO\nthis\tO\nitem\tO\n.\tO\n\nBut\tO\nlet\tO\nme\tO\ntell\tO\nyou\tO\n,\tO\nthe\tO\nmac\tO\nbook\tO\npro\tO\nis\tO\nso\tO\nprofessional\tO\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\ncan\tO\nimagine\tO\nis\tO\nthat\tO\nSony\tO\njumped\tO\non\tO\nearly\tO\nspecifications\tO\nfor\tO\nVista\tO\nrequirements\tB-aspectTerm\nfrom\tO\nMicrosoft\tO\nand\tO\ndesigned\tO\nit\tO\nto\tO\nthose\tO\ninadequate\tO\nrequirements\tO\n.\tO\n\ngo\tO\nfor\tO\nit\tO\n!\tO\n\nI\tO\nhighly\tO\nrecommend\tO\nthis\tO\ncomputer\tO\nfor\tO\nstudents\tO\nlooking\tO\nfor\tO\na\tO\nsolid\tO\nmachine\tO\nto\tO\nget\tO\nthem\tO\nthrough\tO\ncollege\tO\n.\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\n,\tO\nwhich\tO\ngenerally\tO\nfelt\tO\nokay\tO\neven\tO\nfor\tO\nsomeone\tO\nused\tO\nto\tO\na\tO\ndesktop\tB-aspectTerm\nkeyboard\tI-aspectTerm\n,\tO\nnow\tO\nlooks\tO\nterrible\tO\n.\tO\n\nThe\tO\ndisplay\tB-aspectTerm\nis\tO\nawesome\tO\n.\tO\n\nAfter\tO\nyears\tO\nof\tO\noccasionally\tO\npulling\tO\nmy\tO\nhair\tO\nout\tO\nfighting\tO\ncomputer\tO\nviruses\tO\n,\tO\na\tO\ngood\tO\nfriend\tO\nconvinced\tO\nme\tO\nit\tO\nwas\tO\ntime\tO\nto\tO\ngo\tO\nthe\tO\nApple\tO\nroute\tO\n.\tO\n\nThe\tO\nmouse\tB-aspectTerm\nis\tO\na\tO\nlittle\tO\nbit\tO\ndifferent\tO\nthan\tO\nwhat\tO\nyou\tO\n're\tO\nused\tO\nto\tO\nthough-\tO\nit\tO\nhas\tO\none\tO\nbig\tO\nflat\tO\npanel\tO\nand\tO\none\tO\nfull\tO\nbar\tO\n(\tO\ninstead\tO\nof\tO\ntwo\tO\nseparate\tO\nones\tO\n)\tO\nto\tO\nclick\tO\nwith-\tO\nbut\tO\nyou\tO\nget\tO\nused\tO\nto\tO\nit\tO\nquite\tO\nquickly\tO\n.\tO\n\nIt\tO\ntook\tO\nseveral\tO\nweeks\tO\njust\tO\nto\tO\nget\tO\nthem\tO\nto\tO\nacknowledge\tO\nthat\tO\nI\tO\nowned\tO\nthe\tO\nwarranty\tB-aspectTerm\n.\tO\n\nHowever\tO\n,\tO\nthis\tO\nlaptop\tO\nhas\tO\na\tO\nfatal\tO\nflaw\tO\nthat\tO\ni\tO\ndiscovered\tO\nmerely\tO\na\tO\nweek\tO\nafter\tO\nbuying\tO\nit\tO\n.\tO\n\nPerfect\tO\ntrifecta\tO\n!\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\nis\tO\nlike\tO\nno\tO\nother\tO\nlaptop\tO\nkeyboard\tB-aspectTerm\n.\tO\n\nIt\tO\nwas\tO\na\tO\nhuge\tO\nmonstrosity\tO\nof\tO\na\tO\nLaptop\tO\n!\tO\n\n-Computer\tO\ncrashed\tO\nfrequently\tO\nand\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\ndecreased\tO\nvery\tO\nquickly\tO\n.\tO\n\n-I\tO\npropose\tO\nthat\tO\nthey\tO\ncan\tO\njust\tO\nswap\tO\nthe\tO\nhard\tB-aspectTerm\ndrives\tI-aspectTerm\n.\tO\n\nSo\tO\ndo\tO\nn't\tO\nget\tO\nit\tO\n.\tO\n\nit\tO\nwas\tO\na\tO\ntough\tO\nchoice\tO\n.\tO\n\nEvery\tO\ndriver\tB-aspectTerm\non\tO\nthe\tO\ndrivers\tB-aspectTerm\n/\tI-aspectTerm\napplications\tI-aspectTerm\nDVD\tI-aspectTerm\nis\tO\neverything\tO\nyou\tO\nwill\tO\nneed\tO\nfor\tO\na\tO\nreload\tO\n.\tO\n\nThey\tO\nsent\tO\nit\tO\noff\tO\nand\tO\nwithin\tO\n2\tO\nweeks\tO\nI\tO\nhad\tO\nit\tO\nback\tO\ngood\tO\nas\tO\nnew\tO\n.\tO\n\nThe\tO\nAwesomest\tO\nof\tO\nthe\tO\nawesomest\tO\n.\tO\n\nOne\tO\n,\tO\nowning\tO\na\tO\nmac\tO\nis\tO\nessentially\tO\na\tO\nfull\tO\nproduction\tO\nstudio\tO\n(\tO\nin\tO\nthe\tO\ncase\tO\nof\tO\na\tO\nmac\tO\nbook\tO\na\tO\nportable\tO\nversion\tO\n)\tO\n.\tO\n\nI\tO\nwould\tO\nlike\tO\nto\tO\ntell\tO\nyou\tO\nabout\tO\nthe\tO\nbest\tO\nlaptop\tO\nI\tO\njust\tO\ngot\tO\nfrom\tO\nMac\tO\n.\tO\n\nI\tO\n'm\tO\nglad\tO\nit\tO\nwaited\tO\n,\tO\nthis\tO\none\tO\nis\tO\ngreat\tO\n.\tO\n\nI\tO\ncalled\tO\ntheir\tO\nrepair\tB-aspectTerm\ndepot\tI-aspectTerm\nas\tO\nwas\tO\ntold\tO\nthey\tO\nwould\tO\nsend\tO\nMe\tO\na\tO\nnew\tO\nbox\tO\nto\tO\nreturn\tO\nthe\tO\ncomputer\tO\nto\tO\nthe\tO\nrepair\tB-aspectTerm\ndepot\tI-aspectTerm\n.\tO\n\n(\tO\nFor\tO\nthose\tO\nold\tO\nenough\tO\nto\tO\nremember\tO\n,\tO\nit\tO\nis\tO\nsimilar\tO\nto\tO\nBeta\tO\nversus\tO\nVHS\tO\n.\tO\n\nIt\tO\n's\tO\nalso\tO\nfairly\tO\neasy\tO\nto\tO\nuse\tO\nthe\tO\nOperating\tB-aspectTerm\nSystem\tI-aspectTerm\n.\tO\n\nBut\tO\n,\tO\nI\tO\nwould\tO\nrecommend\tO\nthis\tO\nproduct\tO\n.\tO\n\nI\tO\nknow\tO\nthat\tO\nASUS\tO\nis\tO\nknown\tO\nfor\tO\nmaking\tO\nmotherboards\tB-aspectTerm\n,\tO\nbut\tO\nthis\tO\nis\tO\nthe\tO\nworst\tO\ncomputer\tO\nexperience\tO\nthat\tO\nI\tO\nhave\tO\never\tO\nhad\tO\n.\tO\n\nIf\tO\nso\tO\n,\tO\nyou\tO\nmay\tO\nbe\tO\nhaving\tO\nsimilar\tO\nproblems\tO\n.\tO\n\nSome\tO\ndays\tO\nit\tO\n's\tO\njust\tO\nblurry\tO\n,\tO\nsome\tO\ndays\tO\nit\tO\nappears\tO\nthat\tO\nit\tO\n's\tO\nraining\tO\non\tO\nmy\tO\nnice\tO\ndesktop\tO\nbackground\tO\nof\tO\na\tO\nlake\tO\nand\tO\nmountains\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\ngreat\tO\nmachine\tO\n!\tO\n\nThis\tO\nis\tO\nmy\tO\nfirst\tO\npersonal\tO\nSatellite\tO\npurchase\tO\nbut\tO\nhad\tO\nvery\tO\ngood\tO\nexperience\tO\nthrough\tO\nprevious\tO\nSatellite\tO\nwork\tO\nissued\tO\nlaptops\tO\n.\tO\n\nWe\tO\nfigure\tO\nthat\tO\nafter\tO\neverything\tO\nHIS\tO\npc\tO\nactually\tO\nended\tO\nup\tO\ncosting\tB-aspectTerm\n$\tO\n350\tO\nmore\tO\nthan\tO\nmy\tO\noriginal\tO\nMac\tO\n.\tO\n\nSo\tO\nhaving\tO\nthe\tO\nAC\tB-aspectTerm\nplug\tI-aspectTerm\ngo\tO\nout\tO\non\tO\nme\tO\nand\tO\nget\tO\nlose\tO\nor\tO\nI\tO\ncould\tO\nactually\tO\nhere\tO\nit\tO\ninside\tO\nmy\tO\ncomputer\tO\non\tO\ntwo\tO\nof\tO\nthe\tO\nthree\tO\ntimes\tO\nis\tO\nnot\tO\ngood\tO\n.\tO\n\nPeformance\tB-aspectTerm\nis\tO\ngood\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n.\tO\n\nThe\tO\ncomputer\tO\nis\tO\ncurrently\tO\nin\tO\nWest\tO\nVerginia\tO\ndoe\tO\nto\tO\nthe\tO\nmethod\tO\nof\tO\nshipping\tB-aspectTerm\nchoosen\tO\nby\tO\nToshiba\tO\n.\tO\n\nI\tO\ncan\tO\nsee\tO\nwhy\tO\nthe\tO\nhave\tO\nsoooo\tO\nmuch\tO\nmoney\tO\n.\tO\n\nI'M\tO\nREALLY\tO\nFRUSTRATED\tO\nBY\tO\nTHIS\tO\nEXPERIENCE\tO\n.\tO\n\nAnd\tO\nToshiba\tO\nis\tO\ntotally\tO\nunconcerned\tO\n.\tO\n\nSummary\tO\n:\tO\nHP\tO\nknew\tO\nthey\tO\nwere\tO\nshipping\tO\nout\tO\nbad\tO\nBIOS\tB-aspectTerm\nand\tO\ndid\tO\nnothing\tO\nproactive\tO\nto\tO\nresolve\tO\nit\tO\n.\tO\n\nAnd\tO\nin\tO\n6\tO\nmonths\tO\n,\tO\nthere\tO\nhave\tO\nbeen\tO\nno\tO\nfreezing\tO\nup\tO\nand\tO\nno\tO\nblue\tO\n,\tO\npurple\tO\n,\tO\nblack\tO\nor\tO\nany\tO\nother\tO\ntype\tO\nof\tO\nscreen\tO\n.\tO\n\nI\tO\nhad\tO\n3\tO\nmonths\tO\nwhen\tO\nthe\tO\nports\tB-aspectTerm\nstarted\tO\ngoing\tO\nout\tO\n.\tO\n\nthink\tO\ni\tO\nwould\tO\nspend\tO\nlittle\tO\nextra\tO\nto\tO\nget\tO\na\tO\nbetter\tO\nmade\tO\nlaptop\tO\n.\tO\n\nThe\tO\nimprovements\tO\nto\tO\nthe\tO\nOS\tB-aspectTerm\nhave\tO\nbeen\tO\nrelatively\tO\ngradual\tO\n,\tO\nbut\tO\nsubstantive\tO\n.\tO\n\nI\tO\n'll\tO\nwait\tO\nand\tO\nsave\tO\nup\tO\nfor\tO\na\tO\nnew\tO\none\tO\n.\tO\n\nThis\tO\nlaptop\tO\ndoes\tO\neverything\tO\nI\tO\nneed\tO\nit\tO\nto\tO\nvery\tO\nwell\tO\n.\tO\n\nThey\tO\nare\tO\nnot\tO\n.\tO\n\nIt\tO\nmakes\tO\nsorting\tO\nout\tO\nall\tO\nthose\tO\nphotos\tO\non\tO\nmy\tO\ndigital\tO\ncamera\tO\na\tO\nbreeze\tO\n,\tO\nand\tO\norganizing\tO\nthem\tO\nby\tO\nplace\tO\n,\tO\ntime\tO\ntaken\tO\n,\tO\nor\tO\nsending\tO\nthem\tO\nto\tO\nan\tO\nonline\tO\nprint\tO\nshop\tO\n,\tO\nor\tO\nuploading\tO\nthem\tO\nto\tO\nFlickr\tO\nor\tO\nFacebook\tO\netc\tO\n,\tO\nis\tO\nnot\tO\nhard\tO\nat\tO\nall\tO\n.\tO\n\nIts\tO\nbeen\tO\na\tO\nyear\tO\nand\tO\nam\tO\nstill\tO\nwaiting\tO\nto\tO\nsee\tO\nwhat\tO\nthere\tO\ngoing\tO\nto\tO\ndo\tO\nabout\tO\nmy\tO\nlaptop\tO\n.\tO\n\nI\tO\nbought\tO\nit\tO\nto\tO\nuse\tO\nin\tO\ncollege\tO\nand\tO\nit\tO\nis\tO\nperfect\tO\n.\tO\n\nIt\tO\nis\tO\nsuper\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nMany\tO\nof\tO\nmy\tO\nclassmates\tO\ncomputers\tO\nhard\tB-aspectTerm\ndrives\tI-aspectTerm\ncrashed\tO\n.\tO\n\nEase\tO\nof\tO\nuse\tB-aspectTerm\nis\tO\njust\tO\none\tO\nof\tO\nthe\tO\nbenefits\tO\nI\tO\nlove\tO\nabout\tO\nmy\tO\nMac\tO\n.\tO\n\nI\tO\nwould\tO\nn't\tO\nplay\tO\na\tO\nfirst\tO\n-\tO\nperson\tO\nshooter\tO\nwith\tO\nthis\tO\n,\tO\nmind\tO\n,\tO\nbut\tO\nif\tO\nyou\tO\nwanted\tO\nto\tO\nrun\tO\nMS\tB-aspectTerm\nOffice\tI-aspectTerm\n,\tO\nemail\tO\n,\tO\nchat\tO\n,\tO\ndownload\tO\na\tO\nvideo\tO\n,\tO\nlisten\tO\nto\tO\nmusic\tO\nfrom\tO\na\tO\ncertain\tO\nfruit\tO\n-\tO\nnamed\tO\nmusic\tO\nstore\tO\n,\tO\nand\tO\nwere\tO\nlooking\tO\nfor\tO\na\tO\nhighly\tO\nportable\tO\nyet\tO\npowerful\tO\nnetbook\tO\nto\tO\ndo\tO\nthat\tO\nall\tO\nin\tO\n,\tO\nI\tO\n'd\tO\nhighly\tO\nrecommend\tO\nchecking\tO\nthis\tO\nout\tO\n.\tO\n\nThe\tO\n13\tO\n\"\tO\nMacbook\tO\nPro\tO\njust\tO\nfits\tO\nin\tO\nmy\tO\nbudget\tB-aspectTerm\nand\tO\nwith\tO\nfree\tO\nshipping\tB-aspectTerm\nand\tO\nno\tO\ntax\tO\nto\tO\nCA\tO\nthis\tO\nis\tO\nthe\tO\nbest\tO\nprice\tB-aspectTerm\nwe\tO\ncan\tO\nget\tO\nfor\tO\na\tO\ngreat\tO\nproduct\tO\n.\tO\n\nIt\tO\ntook\tO\nme\tO\na\tO\nwhile\tO\ntop\tO\nget\tO\naway\tO\nfrom\tO\nthe\tO\nland\tO\nof\tO\nPCs\tO\n,\tO\nbut\tO\nnow\tO\nthat\tO\nI\tO\nhave\tO\n,\tO\nI\tO\nca\tO\nn't\tO\nsee\tO\nmyself\tO\ngoing\tO\nback\tO\nto\tO\nit\tO\n.\tO\n\nThey\tO\ndiscovered\tO\nthe\tO\nmanufacturer\tO\n's\tO\ndefect\tO\nand\tO\nsent\tO\nit\tO\nin\tO\nfor\tO\nrepair\tO\n.\tO\n\nThe\tO\nsheer\tO\npower\tB-aspectTerm\nand\tO\nflexibility\tB-aspectTerm\nmakes\tO\nthe\tO\nMacBook\tO\nPro\tO\na\tO\nmust\tO\nhave\tO\nfor\tO\nany\tO\ntechie\tO\n!\tO\n\nLOVE\tO\nIT\tO\nLOVE\tO\nIT\tO\nLOVE\tO\nIT\tO\n!\tO\n\nThe\tO\nnotebook\tO\nis\tO\nlacking\tO\na\tO\nHDMI\tB-aspectTerm\nport\tI-aspectTerm\nand\tO\na\tO\nS\tB-aspectTerm\n-\tI-aspectTerm\nvideo\tI-aspectTerm\nport\tI-aspectTerm\nthat\tO\nwould\tO\nenable\tO\none\tO\nto\tO\nhook\tO\nit\tO\nto\tO\na\tO\nTV\tO\n.\tO\n\nThe\tO\nspeakers\tB-aspectTerm\non\tO\nit\tO\nare\tO\nuseless\tO\ntoo\tO\n.\tO\n\nYou\tO\nmay\tO\nsoon\tO\nmistake\tO\nmy\tO\ndigitus\tO\nmedius\tO\nas\tO\na\tO\nlively\tO\npogo\tO\nstick\tO\n.\tO\n\nThis\tO\nis\tO\nnot\tO\nBest\tO\nBuy\tO\n's\tO\nfault\tO\n.\tO\n\nI\tO\nhad\tO\nmeant\tO\nto\tO\npurchase\tO\nthe\tO\nNB205\tO\nand\tO\nbought\tO\nthis\tO\none\tO\nby\tO\naccident\tO\n(\tO\nlong\tO\nstory\tO\n)\tO\n.\tO\n\nMost\tO\nof\tO\nmy\tO\npapers\tO\ncould\tO\nnot\tO\nbe\tO\nsaved\tO\nand\tO\nwhen\tO\nthey\tO\ncould\tO\nbe\tO\n,\tO\nhalf\tO\nthe\tO\ntime\tO\n,\tO\nthe\tO\npapers\tO\nwere\tO\nthen\tO\nerased\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nmy\tO\nMacBook\tO\nPro\tO\nfor\tO\nthree\tO\nyears\tO\nnow\tO\nand\tO\nstill\tO\nlove\tO\nit\tO\n!\tO\n\nBattery\tB-aspectTerm\nis\tO\nlasting\tO\nabout\tO\n6\tO\nhours\tO\nas\tO\nI\tO\nam\tO\nsurfing\tB-aspectTerm\nthe\tI-aspectTerm\nweb\tI-aspectTerm\non\tO\nSundays\tO\nwhile\tO\nchecking\tO\nfootball\tO\nscores\tO\nand\tO\nwatching\tO\nfunny\tO\nYoutube\tO\nvideos\tO\n.\tO\n\nExactly\tO\nthat\tO\n,\tO\nusers\tO\n.\tO\n\nIphoto\tB-aspectTerm\nis\tO\ngreat\tO\nfor\tO\nadding\tO\npictures\tO\nright\tO\nto\tO\nfacebook\tO\nand\tO\nother\tO\nsocial\tO\nnetworking\tO\nsites\tO\n.\tO\n\nI\tO\nhave\tO\nrecommended\tO\nthis\tO\nlaptop\tO\nto\tO\neveryone\tO\nI\tO\nknow\tO\nwho\tO\nis\tO\nbuying\tO\none\tO\n.\tO\n\nthey\tO\nwill\tO\nnot\tO\nlet\tO\nyou\tO\ndown\tO\n.\tO\n\nAlmost\tO\n4\tO\nyears\tO\nago\tO\nI\tO\nbought\tO\nwhat\tO\nwas\tO\nthen\tO\nthe\tO\ncurrent\tO\n,\tO\nup\tO\nto\tO\ndate\tO\nHP\tO\nPavilion\tO\n--\tO\nIf\tO\nI\tO\nrecall\tO\ncorrectly\tO\n,\tO\nit\tO\nwas\tO\nthe\tO\ndv\tO\n1300\tO\nt.\tO\n\nIt\tO\n's\tO\nnot\tO\na\tO\nrecommendation\tO\n,\tO\nit\tO\n'\tO\na\tO\nplea\tO\n.\tO\n\nIn\tO\nearly\tO\nMay\tO\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nthis\tO\ntime\tO\nI\tO\nonly\tO\nhad\tO\nit\tO\nback\tO\nfor\tO\n1\tO\nday\tO\nbefore\tO\nit\tO\nhad\tO\na\tO\nNEW\tO\nissue\tO\nso\tO\nit\tO\nwas\tO\nsent\tO\nback\tO\nin\tO\nfor\tO\nthe\tO\n6th\tO\ntime\tO\nthey\tO\n\"\tO\nexpedited\tO\n\"\tO\nthe\tO\nrepairs\tO\nso\tO\nI\tO\nwas\tO\nonly\tO\nsupposed\tO\nto\tO\nhave\tO\nto\tO\nbe\tO\nwithout\tO\nit\tO\nfor\tO\n3\tO\ndays\tO\nand\tO\nit\tO\nwas\tO\nsupposed\tO\nto\tO\nbe\tO\nfixed\tO\n,\tO\nby\tO\na\tO\n\"\tO\nSenior\tB-aspectTerm\nTech\tI-aspectTerm\n\"\tO\n.\tO\n\nSome\tO\nfeatures\tB-aspectTerm\nare\tO\nnt\tO\nfriendly\tO\n(\tO\nvolume\tB-aspectTerm\nwheel\tI-aspectTerm\n,\tO\nsound\tB-aspectTerm\nquality\tI-aspectTerm\n,\tO\netc\tO\n.\tO\n\nA\tO\ncheaper\tO\nprice\tB-aspectTerm\nshould\tO\nnot\tO\nequal\tO\na\tO\n\"\tO\ncheap\tO\n\"\tO\nproduct\tO\n.\tO\n\n-When\tO\nI\tO\nstarted\tO\nworrying\tO\nfor\tO\nnot\tO\nhearing\tO\nanything\tO\nfrom\tO\nthem\tO\n,\tO\nI\tO\ntried\tO\nto\tO\ncall\tO\n.\tO\n\nI\tO\nthink\tO\nthe\tO\nmanual\tB-aspectTerm\nis\tO\nsomewhere\tO\non\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n,\tO\nbut\tO\nI\tO\nrather\tO\nhave\tO\na\tO\nhard\tO\ncopy\tO\n.\tO\n\ngot\tO\nanother\tO\n1\tO\n,\tO\nand\tO\nsame\tO\nissue\tO\n.\tO\n\nThank\tO\nyou\tO\nBest\tO\nBuy\tO\nfor\tO\nputting\tO\nmy\tO\ncomputer\tO\ntogether\tO\nand\tO\ninstalling\tO\nmy\tO\nfirst\tO\nsoftware\tB-aspectTerm\n-\tO\nyou\tO\nguys\tO\nwere\tO\nGREAT\tO\ntoo\tO\n!\tO\n\nThey\tO\nwere\tO\nable\tO\nto\tO\nset\tO\n-\tO\nup\tO\nwith\tO\nlabtops\tO\nthemselves\tO\nwithin\tO\na\tO\nfew\tO\nminutes\tO\n.\tO\n\nI\tO\nconsider\tO\nmyself\tO\nan\tO\naverage\tO\nuser\tO\nand\tO\nthis\tO\ncomputer\tO\nserves\tO\nmy\tO\nneed\tO\n.\tO\n\nAdjust\tO\nthe\tO\nsensitivity\tB-aspectTerm\nsince\tO\nit\tO\n's\tO\nnot\tO\nthat\tO\nresponsive\tO\nto\tO\nbegin\tO\nwith\tO\n.\tO\n\nAfter\tO\na\tO\ncouple\tO\nof\tO\nyears\tO\n,\tO\nmy\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nbegan\tO\nto\tO\ndiminish\tO\nbut\tO\nwas\tO\nreplaced\tO\nfor\tO\nfree\tO\ndue\tO\nto\tO\na\tO\ncompany\tO\n-\tO\nwide\tO\nrecall\tO\nof\tO\nmy\tO\nparticular\tO\nbattery\tB-aspectTerm\n.\tO\n\nThe\tO\nsystem\tB-aspectTerm\nconstantly\tO\noverheats\tO\n,\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\ntoo\tO\nshort\tO\n,\tO\nthe\tO\ncase\tB-aspectTerm\nis\tO\ncoming\tO\napart\tO\n,\tO\nand\tO\nmy\tO\ncore\tB-aspectTerm\napplications\tI-aspectTerm\nthat\tO\nI\tO\nuse\tO\nevery\tO\nday\tO\nin\tO\nmy\tO\nwork\tO\nas\tO\na\tO\ngraphic\tO\nartist\tO\nrun\tO\npoorly\tO\n.\tO\n\nI\tO\nwould\tO\nnever\tO\nbuy\tO\na\tO\nDell\tO\nagain\tO\n.\tO\n\nLater\tO\nit\tO\nheld\tO\nzero\tO\ncharge\tO\nand\tB-aspectTerm\nits\tO\nreplacement\tO\nworked\tO\nfor\tO\nless\tO\nthan\tO\nthree\tO\nmonths\tO\n.\tO\n\nThe\tO\ncompany\tO\nsent\tO\nme\tO\na\tO\nwhole\tO\nnew\tO\ncord\tO\novernight\tB-aspectTerm\nand\tO\napologized\tO\n.\tO\n\nIt\tO\n's\tO\neven\tO\neasy\tO\nto\tO\nhook\tB-aspectTerm\nup\tI-aspectTerm\nto\tI-aspectTerm\nother\tI-aspectTerm\nwireless\tI-aspectTerm\nnetworks\tI-aspectTerm\n.\tO\n\nAlso\tO\n,\tO\nI\tO\nhave\tO\nhad\tO\nalot\tO\nof\tO\ntrouble\tO\nwith\tO\nthe\tO\nshift\tO\nkey\tB-aspectTerm\nto\tI-aspectTerm\ngo\tO\nto\tO\nother\tO\nlines\tO\n.\tO\n\nThe\tO\nrep\tB-aspectTerm\ndid\tO\nnot\tO\neven\tO\nanswer\tO\nmy\tO\nquestion\tO\n,\tO\nI\tO\nhad\tO\nto\tO\nask\tO\nhim\tO\n,\tO\nif\tO\nhe\tO\nunderstood\tO\nwhat\tO\nI\tO\nask\tO\nor\tO\nif\tO\nhe\tO\nspoke\tO\nenglish\tO\nbecause\tO\nhe\tO\ndid\tO\nn't\tO\neven\tO\ntry\tO\nto\tO\nacknowledge\tO\nmy\tO\nquestion\tO\n.\tO\n\nI\tO\nam\tO\nnow\tO\nfrustrated\tO\nthat\tO\nI\tO\nstill\tO\nhave\tO\nto\tO\nuse\tO\nmy\tO\nwork\tO\nissued\tO\nWindows\tO\nlaptop\tO\n!\tO\n\nIt\tO\ngives\tO\nme\tO\nthe\tO\npower\tB-aspectTerm\nand\tO\nspeed\tB-aspectTerm\nthat\tO\nI\tO\nneed\tO\nto\tO\nrun\tO\nall\tO\nthe\tO\nprograms\tB-aspectTerm\nI\tO\nuse\tO\nto\tO\nedit\tO\n.\tO\n\niLife\tB-aspectTerm\nis\tO\neasily\tO\ncompatible\tO\nwith\tO\nMicrosoft\tB-aspectTerm\nOffice\tI-aspectTerm\nso\tO\nyou\tO\ncan\tO\nsend\tO\nand\tO\nreceive\tO\nfiles\tO\nfrom\tO\na\tO\nPC\tO\n.\tO\n\nThey\tO\ndo\tO\nn't\tO\ncrash\tO\n.\tO\n\nAs\tO\na\tO\ncomputer\tO\nscience\tO\nstudent\tO\nin\tO\ncollege\tO\n,\tO\nI\tO\nfind\tO\nthat\tO\nthe\tO\nportability\tB-aspectTerm\n,\tO\nlongevity\tB-aspectTerm\n,\tO\nand\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\nof\tO\nthis\tO\ncomputer\tO\nmake\tO\nme\tO\n(\tO\nshockingly\tO\n)\tO\nwant\tO\nto\tO\ndo\tO\nhomework\tO\nmore\tO\n;\tO\n\nThis\tO\nNotebook\tO\nrestarts\tO\nevery\tO\ntime\tO\nthere\tO\nis\tO\na\tO\nnew\tO\nupdate\tO\n,\tO\nso\tO\nif\tO\nyou\tO\ndo\tO\nn't\tO\nsave\tO\nyour\tO\nfiles\tO\nand\tO\ninformation\tO\n,\tO\neverything\tO\nwill\tO\nbe\tO\nlost\tO\n.\tO\n\nI\tO\nlove\tO\nthis\tO\nlittle\tO\none\tO\n.\tO\n\nSo\tO\nnot\tO\nhaving\tO\nmy\tO\nlaptop\tO\nwas\tO\ndiscouraging\tO\n.\tO\n\nI\tO\nfine\tO\nApple\tO\nMC373LL\tO\n/\tO\nA\tO\n2.66GHz\tO\n15\tO\n\"\tO\nMacboook\tO\nPro\tO\nNotebook\tO\nmeets\tO\nall\tO\nmy\tO\nneeds\tO\nfor\tO\na\tO\nlaptop\tO\ncomputer\tO\nwhen\tO\non\tO\nthe\tO\ngo\tO\n.\tO\n\nAgain\tO\nI\tO\nsent\tO\nit\tO\nback\tO\nand\tO\nthey\tO\nreplaced\tO\nthe\tO\nmotherboard\tO\nand\tB-aspectTerm\nsome\tO\nfan\tO\ninside\tB-aspectTerm\n.\tO\n\nFully\tO\ncharged\tB-aspectTerm\n,\tO\nthe\tO\nMacBook\tO\nPro\tO\ncan\tO\nlast\tO\nabout\tO\nfive\tO\nhours\tO\nunplugged\tO\n.\tO\n\nIt\tO\nwas\tO\na\tO\nhard\tO\ndecision\tO\nfor\tO\nme\tO\nsince\tO\nthe\tO\nMacBook\tO\nPro\tO\nlooked\tO\nso\tO\nappealing\tO\n.\tO\n\n1st\tO\nhand\tO\nexperience\tO\nis\tO\nvery\tO\nimportant\tO\n,\tO\nespecially\tO\nfor\tO\na\tO\nnew\tO\ncustomer\tO\n.\tO\n\nI\tO\nespecially\tO\nappreciate\tO\nthe\tO\nfact\tO\nthat\tO\nit\tO\nhas\tO\nalmost\tO\nzero\tO\nviruses\tO\nand\tO\nspyware\tO\nproblems\tO\n!\tO\n\nEven\tO\nthough\tO\nit\tO\nis\tO\nmuch\tO\nmore\tO\nexpensive\tO\nthan\tO\nmany\tO\nPC\tO\nlaptops\tO\n,\tO\nit\tO\nis\tO\nworth\tO\nthe\tO\nprice\tB-aspectTerm\n.\tO\n\nI\tO\nknow\tO\nthere\tO\nare\tO\nway\tO\nbetter\tO\nlaptops\tO\nout\tO\nthere\tO\nfor\tO\nthe\tO\nsame\tO\nprice\tB-aspectTerm\n,\tO\nand\tO\nwhy\tO\nspend\tO\nmoney\tO\non\tO\nshit\tO\nwhen\tO\nyou\tO\ncan\tO\ngo\tO\nout\tO\nand\tO\nget\tO\nyourself\tO\na\tO\nperfectly\tO\ndecent\tO\nlaptop\tO\nthat\tO\ndoes\tO\nnt\tO\nsuck\tO\ntotal\tO\nmonkey\tO\nballs\tO\n.\tO\n\nFor\tO\nme\tO\n,\tO\nkeys\tB-aspectTerm\nwere\tO\nstarting\tO\nto\tO\nget\tO\nstuck\tO\nand\tO\nwould\tO\nn't\tO\ntype\tO\nvery\tO\nwell\tO\n.\tO\n\nI\tO\ndo\tO\nn't\tO\nlike\tO\nthis\tO\ncompany\tO\nnor\tO\nthe\tO\ntoshiba\tO\nbrand\tO\n,\tO\nand\tO\nI\tO\n'll\tO\nnever\tO\nbuy\tO\nanother\tO\none\tO\nbecause\tO\nI\tO\n've\tO\nput\tO\nmore\tO\ninto\tO\nit\tO\nthen\tO\nit\tO\nis\tO\nworth\tO\n.\tO\n\nca\tO\nn't\tO\nreinstall\tO\nwith\tO\nstandard\tB-aspectTerm\nos\tI-aspectTerm\ncd\tI-aspectTerm\nbecause\tO\nof\tO\nproprietary\tB-aspectTerm\nhardware\tI-aspectTerm\ndrivers\tI-aspectTerm\n.\tO\n\nHowever\tO\n,\tO\nthis\tO\nwill\tO\nbe\tO\nmy\tO\nlast\tO\nas\tO\nwell\tO\n.\tO\n\nThere\tO\nis\tO\na\tO\nsmall\tO\nred\tO\ncircle\tO\nnext\tO\nto\tO\nit\tO\nwith\tO\na\tO\nx\tO\nin\tO\nthe\tO\nmiddle\tO\n,\tO\nand\tO\nwhen\tO\nI\tO\nclick\tO\non\tO\nit\tO\nit\tO\nsays\tO\n:\tO\n\"\tO\nConsider\tO\nreplacing\tO\nyour\tO\nbattery\tB-aspectTerm\n\"\tO\nand\tO\nit\tO\ndoes\tO\nnot\tO\nhold\tO\nfull\tO\ncharge\tB-aspectTerm\n.\tO\n\nSO\tO\n?\tO\nHOW\tO\nCAN\tO\nYOU\tO\nSOLVE\tO\nIT\tO\n?\tO\nC'mon\tO\n,\tO\nI\tO\njust\tO\nbought\tO\nthe\tO\nnetbook\tO\n2\tO\nweeks\tO\nago\tO\n.\tO\n\nThe\tO\ncomputer\tO\nwas\tO\ntwo\tO\nweeks\tO\nlate\tO\nin\tO\ndelivery\tB-aspectTerm\nbecause\tO\nHP\tO\nforgot\tO\nto\tO\ncomplete\tO\nthe\tO\nrequired\tO\nimport\tO\npaperwork\tO\n.\tO\n\nIf\tO\nyou\tO\n're\tO\nlooking\tO\nfor\tO\na\tO\ngreat\tO\nlaptop\tO\n,\tO\nyou\tO\n've\tO\nfound\tO\nthe\tO\nbest\tO\nhere\tO\n.\tO\n\nThe\tO\nfirst\tO\nprogramm\tB-aspectTerm\nI\tO\nswitched\tO\non\tO\nwas\tO\na\tO\ngame\tO\nfor\tO\nmy\tO\nchildren\tO\n.\tO\n\nI\tO\nhave\tO\nbeen\tO\nvery\tO\npleased\tO\nwith\tO\nthe\tO\nperformance\tB-aspectTerm\nof\tO\nthis\tO\nlaptop\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nmy\tO\nMacBook\tO\nfor\tO\nalmost\tO\n6\tO\nmonths\tO\nand\tO\ncan\tO\nhonestly\tO\nsay\tO\nthat\tO\nI\tO\nwill\tO\nNEVER\tO\nbuy\tO\nanother\tO\ncomputer\tO\nif\tO\nit\tO\nis\tO\nnot\tO\na\tO\nMac\tO\n.\tO\n\nI\tO\n've\tO\nalways\tO\nowned\tO\na\tO\nPC\tO\nand\tO\ndecided\tO\nto\tO\ntry\tO\na\tO\nMacBook\tO\nto\tO\nsee\tO\nwhat\tO\nit\tO\n's\tO\nall\tO\nabout\tO\n.\tO\n\nOn\tO\ntwo\tO\noccasions\tO\nthe\tO\ncomputer\tO\ns\tO\ncalendar\tO\ntold\tO\nme\tO\nit\tO\nwas\tO\n1969\tO\n.\tO\n\nI\tO\nbought\tO\nit\tO\nfor\tO\nmy\tO\nmom\tO\nand\tO\nshe\tO\nreports\tO\nthat\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nlasts\tO\nall\tO\nday\tO\nfor\tO\nher\tO\n,\tO\nit\tO\n's\tO\nvery\tO\nlightweight\tO\n,\tO\nand\tO\nthe\tO\nresponse\tB-aspectTerm\nfor\tO\nthe\tO\ncomputing\tO\nshe\tO\n's\tO\ndoing\tO\n(\tO\nInternet\tB-aspectTerm\nfocused\tI-aspectTerm\nactivity\tI-aspectTerm\n:\tO\nmail\tO\n,\tO\nresearch\tO\n,\tO\netc\tO\n.\tO\n)\tO\nis\tO\nexcellent\tO\n;\tO\n\nIts\tO\nvery\tO\nnice\tO\nand\tO\nonce\tO\nyou\tO\nlearn\tO\nthe\tO\nfeatures\tB-aspectTerm\nyou\tO\nwill\tO\nbe\tO\nso\tO\nhappy\tO\nto\tO\nhave\tO\nsuch\tO\na\tO\nsophisticated\tO\ncomputer\tO\n.\tO\n\nOverall\tO\n,\tO\nthis\tO\nis\tO\na\tO\nwonderful\tO\ncomputer\tO\nand\tO\ndefinitly\tO\nworth\tO\nthe\tO\npurchase\tO\n!\tO\n\nIt\tO\ncame\tO\nalot\tO\nfaster\tO\nthan\tO\nI\tO\nthought\tO\nit\tO\nwould\tO\nhave\tO\nwhich\tO\nwas\tO\nreally\tO\nexciting\tO\n.\tO\n\nThen\tO\nto\tO\nmake\tO\nmatters\tO\nworst\tO\n,\tO\nthere\tO\nis\tO\nnoone\tO\nthat\tO\nthey\tO\ncan\tO\ntransfer\tO\nyou\tO\nto\tO\n.\tO\n\nIt\tO\nis\tO\nsleek\tO\nand\tO\nlightweight\tO\nand\tO\ncharges\tB-aspectTerm\nquickly\tO\nwhen\tO\nneeded\tO\n.\tO\n\nalso\tO\nyou\tO\nmay\tO\nneed\tO\nto\tO\ncharge\tB-aspectTerm\nit\tO\nonce\tO\na\tO\nday\tO\n,\tO\nif\tO\nfor\tO\nmedium\tO\nuse\tO\nevery\tO\nthing\tO\nfast\tO\nand\tO\neasy\tO\nwith\tO\nmac\tO\nthe\tO\nsize\tO\nand\tO\nlook\tO\nis\tO\nthe\tO\nmost\tO\nfeature\tO\nthat\tO\nattracted\tO\nme\tO\nto\tO\nit\tO\n.\tO\n\nBut\tO\nif\tO\nyou\tO\nare\tO\nin\tO\nthe\tO\ncomputer\tO\nfield\tO\nyou\tO\nprobably\tO\nwould\tO\nn't\tO\nbe\tO\nhere\tO\n.\tO\n\nThe\tO\ngreat\tO\n18\tO\nmonth\tO\nsame\tO\nas\tO\ncash\tO\nfinancing\tO\nand\tO\nAdvance\tO\nProtection\tO\nPlan\tO\nwhich\tO\nincludes\tO\naccidents\tO\nlike\tO\nspills\tO\n.\tO\n\nI\tO\ncould\tO\nnot\tO\nhandle\tO\nit\tO\none\tO\nhand\tO\nlike\tO\nI\tO\ncan\tO\nthe\tO\nreplacement\tO\ncomputer\tO\nI\tO\npurchased\tO\n.\tO\n\nThe\tO\nnew\tO\nMacbook\tO\nPro\tO\n15\tO\ninch\tO\ni7\tO\nis\tO\nnothing\tO\nshort\tO\nof\tO\namazing\tO\n.\tO\n\ni\tO\nwould\tO\nnever\tO\ngo\tO\nback\tO\nany\tO\nmore\tO\n,\tO\ni\tO\nlove\tO\nthis\tO\ncomputer\tO\nso\tO\nmuch\tO\nand\tO\ni\tO\nwould\tO\nrecommend\tO\nit\tO\nto\tO\neveryone\tO\n.\tO\n\nthey\tO\nrespond\tO\n:\tO\n\"\tO\nyour\tO\ndissatisfaction\tO\nis\tO\nnoted\tO\n\"\tO\n...\tO\n\nI\tO\nwas\tO\neven\tO\nable\tO\nto\tO\nuninstall\tO\nMcAffe\tO\nand\tO\ninstall\tO\none\tO\nof\tO\nmy\tO\nSymantec\tO\nlicenses\tO\nwith\tO\na\tO\nno\tO\nissues\tO\nwhatsoever\tO\n.\tO\n\n(\tO\nThe\tO\niBook\tB-aspectTerm\nbackup\tI-aspectTerm\nalso\tO\nuses\tO\na\tO\nfirewire\tB-aspectTerm\nconnection\tI-aspectTerm\n)\tO\n.\tO\n\nI\tO\ndid\tO\nthink\tO\nit\tO\nhad\tO\na\tO\ncamera\tB-aspectTerm\nbecause\tO\nthat\tO\nwas\tO\none\tO\nof\tO\nmy\tO\nrequirements\tO\n,\tO\nbut\tO\nforgot\tO\nto\tO\ncheck\tO\nin\tO\nthe\tO\nspecifications\tB-aspectTerm\non\tO\nthis\tO\none\tO\nbefore\tO\nI\tO\npurchased\tO\n.\tO\n\nAlso\tO\nthe\tO\ndisplay\tB-aspectTerm\nis\tO\nexceptional\tO\n!\tO\n\nThis\tO\nis\tO\nstill\tO\na\tO\nfairly\tO\ngood\tO\nupgrade\tO\nto\tO\na\tO\nlaptop\tO\nthat\tO\nwas\tO\nabout\tO\n4\tO\nyears\tO\nold\tO\n.\tO\n\nThe\tO\ncomputer\tO\nwas\tO\nshipped\tO\nto\tO\ntheir\tO\nrepair\tB-aspectTerm\ndepot\tI-aspectTerm\non\tO\njune\tO\n24\tO\nand\tO\nreturned\tO\non\tO\nJuly\tO\n2\tO\nseems\tO\nlike\tO\na\tO\nshort\tO\nturn\tO\naround\tO\ntime\tO\nexcept\tO\nthe\tO\ncomputer\tO\nwas\tO\nnot\tO\nrepaired\tO\nwhen\tO\nit\tO\nwas\tO\nreturned\tO\n.\tO\n\nThis\tO\nis\tO\nbasically\tO\nthe\tO\nbest\tO\nlaptop\tO\nI\tO\nhave\tO\never\tO\nhad\tO\nor\tO\nused\tO\n.\tO\n\n(\tO\n3DMARK6\tO\nscore\tO\nis\tO\nonly\tO\n8500\tO\n)\tO\n.\tO\n\nI\tO\ntell\tO\neveryone\tO\nI\tO\nsee\tO\nout\tO\nlooking\tO\nto\tO\nget\tO\nthis\tO\nor\tO\nanother\tO\nToshiba\tO\n.\tO\n\nSo\tO\nhonestly\tO\n,\tO\nI\tO\nwas\tO\nn't\tO\nexpecting\tO\nanything\tO\nless\tO\nthan\tO\nperfection\tO\n,\tO\nand\tO\nI\tO\nwas\tO\nn't\tO\ndisappointed\tO\n.\tO\n\nLearning\tO\nall\tO\nof\tO\nthe\tO\nkeyboard\tB-aspectTerm\nshortcuts\tI-aspectTerm\nonly\tO\ntook\tO\na\tO\nfew\tO\nminutes\tO\nto\tO\nget\tO\nused\tO\nto\tO\nas\tO\nsome\tO\nof\tO\nthe\tO\nshortcuts\tB-aspectTerm\nare\tO\nthe\tO\nsame\tO\non\tO\nWindows\tO\nmachines\tO\n.\tO\n\nMy\tO\nfriends\tO\nare\tO\nin\tO\nawe\tO\nevery\tO\ntime\tO\nthey\tO\ncome\tO\nover\tO\n!\tO\n\nlittle\tO\nshort\tO\non\tO\nRAM\tB-aspectTerm\nbut\tO\nyou\tO\nget\tO\nwhat\tO\nyou\tO\npay\tO\nfor\tO\n.\tO\n\nIt\tO\ndid\tO\nn't\tO\ncome\tO\nwith\tO\nany\tO\nsoftware\tB-aspectTerm\ninstalled\tO\noutside\tO\nof\tO\nwindows\tB-aspectTerm\nmedia\tI-aspectTerm\n,\tO\nbut\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n,\tO\nI\tO\nwas\tO\nvery\tO\npleased\tO\nwith\tO\nthe\tO\ncondition\tO\nand\tO\nthe\tO\noverall\tO\nproduct\tO\n.\tO\n\nThe\tO\nfirst\tO\none\tO\nI\tO\nhad\tO\nwas\tO\na\tO\n2006\tO\nmodel\tO\n,\tO\nnot\tO\nthe\tO\nPro\tO\n.\tO\n\nTHEN\tO\n,\tO\none\tO\nmonth\tO\nafter\tO\nthe\tO\nwarranty\tB-aspectTerm\nexpired\tO\n,\tO\nthe\tO\nreplacement\tB-aspectTerm\ncharger\tI-aspectTerm\nwent\tO\n.\tO\n\n2nd\tO\nMac\tO\nbook\tO\nI\tO\nhave\tO\npurchased\tO\nfrom\tO\nMacConnection\tO\n.\tO\n\nI\tO\nlove\tO\na\tO\n\"\tO\npc\tO\n\"\tO\nbut\tO\nI\tO\nwas\tO\nready\tO\nfor\tO\na\tO\nchange\tO\nand\tO\ntired\tO\nof\tO\nthe\tO\nwindows\tB-aspectTerm\nsystem\tI-aspectTerm\n.\tO\n\nYour\tO\ncursor\tB-aspectTerm\nwill\tO\nend\tO\nup\tO\nall\tO\nover\tO\nthe\tO\nfreaking\tO\nplace,,,it\tO\n's\tO\nnot\tO\nuncommon\tO\nfor\tO\nme\tO\nto\tO\naccidentally\tO\ndelete\tO\nwords\tO\n,\tO\nsentences\tO\n,\tO\nparagraphs\tO\nbecause\tO\nof\tO\nthis\tO\nmousepad\tB-aspectTerm\n.\tO\n\nOther\tO\ninstalled\tO\nfeatures\tB-aspectTerm\n,\tO\nsuch\tO\nas\tO\ncertain\tO\nprinter\tB-aspectTerm\nsoftware\tI-aspectTerm\n,\tO\nare\tO\nalso\tO\nmost\tO\nattractive\tO\n.\tO\n\nI\tO\nnormally\tO\ndo\tO\nnt\tO\nparticipate\tO\nin\tO\nreviews\tO\n/\tO\nsurveys\tO\nbut\tO\nthis\tO\nlaptop\tO\nhas\tO\nnot\tO\ngiven\tO\nme\tO\nany\tO\nproblems\tO\nand\tO\nhope\tO\nto\tO\nshare\tO\nmy\tO\nthoughts\tO\n...\tO\n\nMost\tO\nof\tO\nthe\tO\nlarge\tO\nbags\tO\nare\tO\nfor\tO\na\tO\n17\tO\ninch\tO\n.\tO\n\nI\tO\nwork\tO\nin\tO\nfilm\tO\nediting\tO\nand\tO\npost\tO\nproduction\tO\n,\tO\nso\tO\nI\tO\nneed\tO\na\tO\nlaptop\tO\nthat\tO\nnot\tO\nonly\tO\nhas\tO\npower\tB-aspectTerm\n,\tO\nbut\tO\nmemory\tB-aspectTerm\nand\tO\nspeed\tB-aspectTerm\nas\tO\nwell\tO\n.\tO\n\nI\tO\ntook\tO\nit\tO\nhome\tO\nand\tO\nwithin\tO\n30\tO\nmin\tO\n,\tO\nit\tO\nwas\tO\nfreezing\tO\nup\tO\nand\tO\ndid\tO\nthe\tO\n\"\tO\nblue\tO\nscreen\tO\nof\tO\ndeath\tO\n\"\tO\n.\tO\n\nAt\tO\nfirst\tO\nwhen\tO\nI\tO\ngot\tO\nthis\tO\nproduct\tO\n,\tO\nI\tO\nloved\tO\nit\tO\n.\tO\n\nI\tO\nthink\tO\nthis\tO\ncomputer\tO\nis\tO\nsuper\tO\nlame\tO\n.\tO\n\nIt\tO\nhad\tO\na\tO\nseventeen\tB-aspectTerm\ninch\tI-aspectTerm\nscreen\tI-aspectTerm\nwhich\tO\nI\tO\nwanted\tO\n,\tO\nbut\tO\nI\tO\ndid\tO\nn't\tO\nrealize\tO\nat\tO\nthe\tO\ntime\tO\nit\tO\nwould\tO\nbe\tO\nsuch\tO\na\tO\nmonster\tO\n!\tO\n\nEven\tO\ndoing\tO\nso\tO\n,\tO\nthe\tO\nhinge\tB-aspectTerm\nmay\tO\njust\tO\nbe\tO\nslightly\tO\ntightened\tO\nonly\tO\n.\tO\n\ncompany\tO\nprovides\tO\nUPS\tO\nshipping\tB-aspectTerm\n,\tO\nfast\tO\n,\tO\ngreat\tO\n!\tO\n\nI\tO\nwould\tO\ntell\tO\nthe\tO\ntechnician\tB-aspectTerm\nI\tO\nknew\tO\nexactly\tO\nwhat\tO\nwas\tO\nwrong\tO\nwith\tO\nit\tO\nbut\tO\nthey\tO\ndid\tO\nnot\tO\nlisten\tO\nand\tO\nI\tO\nhad\tO\nto\tO\ngo\tO\nthrough\tO\na\tO\nbunch\tO\nof\tO\njunk\tO\nto\tO\nget\tO\nthem\tO\nto\tO\ntell\tO\nme\tO\nI\tO\nneeded\tO\nto\tO\nsend\tO\nthe\tO\ncomputer\tO\nin\tO\n.\tO\n\nTHIS\tO\nis\tO\nwhat\tO\na\tO\nlaptop\tO\nis\tO\nsupposed\tO\nto\tO\nbe\tO\n.\tO\n\nThen\tO\nI\tO\n've\tO\nfixed\tO\nthe\tO\nDC\tO\njack\tB-aspectTerm\n(\tI-aspectTerm\ninside\tO\nthe\tO\nunit\tO\n)\tO\n,\tO\nrewired\tO\nthe\tO\nDC\tO\njack\tB-aspectTerm\nto\tI-aspectTerm\nthe\tO\nOUTside\tO\nof\tO\nthe\tO\nlaptop\tO\n,\tO\nreplaced\tO\nthe\tO\npower\tO\nbrick\tB-aspectTerm\n.\tI-aspectTerm\n\nI\tO\npurchased\tO\ntwo\tO\nlaptops\tO\n(\tO\nfor\tO\nmy\tO\nhusband\tO\nand\tO\n16\tO\nyear\tO\nold\tO\ndaughter\tO\n)\tO\n.\tO\n\nMore\tO\nrelieved\tO\nthan\tO\nanything\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nhas\tO\ngreat\tO\nscreen\tB-aspectTerm\nquality\tI-aspectTerm\n,\tO\nand\tO\nevery\tO\nso\tO\nlight\tO\nweight\tO\n.\tO\n\nGreat\tO\nproduct\tO\n,\tO\nvery\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\ngreat\tO\ngraphics\tB-aspectTerm\n.\tO\n\nSummary\tO\n:\tO\nSpend\tO\nyour\tO\nmoney\tO\nelsewhere\tO\n\nbelieve\tO\nme\tO\napple\tO\nhas\tO\na\tO\nreputation\tO\n.\tO\n\nThe\tO\niLife\tB-aspectTerm\nsoftware\tI-aspectTerm\nthat\tO\ncomes\tO\nwith\tO\nthe\tO\ncomputer\tO\nis\tO\nso\tO\nsimple\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nproduces\tO\na\tO\ngreat\tO\nfinished\tO\nproduct\tO\n.\tO\n\nThe\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nwebcam\tI-aspectTerm\nis\tO\ngreat\tO\nfor\tO\nSkype\tO\nand\tO\nsimilar\tO\nvideo\tO\n-\tO\nchat\tO\nservices\tO\n.\tO\n\nThe\tO\nshop\tO\nwill\tO\ndefinitely\tO\npush\tO\nthe\tO\nproblem\tO\nto\tO\nthe\tO\nservice\tB-aspectTerm\ncenter\tI-aspectTerm\n.\tO\n\nPC\tO\nusers\tO\nwork\tO\nin\tO\nWord\tB-aspectTerm\n,\tO\nwhile\tO\nMac\tO\nusers\tO\nwork\tO\nin\tO\nPages\tB-aspectTerm\n.\tO\n\nI\tO\nam\tO\nable\tO\nto\tO\norganize\tO\nmy\tO\npics\tO\n,\tO\nmusic\tO\nand\tO\nfiles\tO\neasily\tO\n.\tO\n\nWhile\tO\nI\tO\nmostly\tO\nuse\tO\nit\tO\nfor\tO\nemail\tO\n,\tO\ninternet\tB-aspectTerm\nand\tO\ngaming\tB-aspectTerm\n,\tO\nI\tO\n'm\tO\nconfident\tO\nall\tO\nother\tO\napplications\tB-aspectTerm\nlive\tO\nup\tO\nto\tO\nthe\tO\nhigh\tO\nstandard\tO\nI\tO\n've\tO\ncome\tO\nto\tO\nappreciate\tO\nfrom\tO\nMac\tO\nlaptops\tO\n.\tO\n\nI\tO\n've\tO\nbeen\tO\nhaving\tO\nendless\tO\nproblems\tO\nsince\tO\nI\tO\nbought\tO\nthe\tO\ncomputer\tO\n-\tO\nonly\tO\n1\tO\nmonth\tO\nago\tO\n\nThe\tO\nperfect\tO\nnotebook\tO\n...\tO\n\nThis\tO\nlaptop\tO\nlooks\tO\ngreat\tO\non\tO\nthe\tO\nsurface\tO\n:\tO\n17\tB-aspectTerm\n\"\tI-aspectTerm\ninch\tI-aspectTerm\nscreen\tI-aspectTerm\n,\tO\ngood\tO\nprice\tO\n-\tB-aspectTerm\npoint\tI-aspectTerm\n,\tI-aspectTerm\nnice\tO\nappearance\tO\n,\tB-aspectTerm\nboots\tO\nup\tB-aspectTerm\nquickly\tO\n,\tO\nruns\tO\nfast\tO\netc\tO\n.\tO\n\nThe\tO\napple\tO\nsystems\tO\nare\tO\nover\tO\npriced\tO\nluxurys\tO\nthat\tO\narn't\tO\nworth\tO\nwhat\tO\nthey\tO\nare\tO\nbeing\tO\ncharged\tO\nfor\tO\n,\tO\nthis\tO\nmodel\tO\n's\tO\nspecifications\tB-aspectTerm\nare\tO\nfar\tO\nfrom\tO\nbeing\tO\nimpressive\tO\nand\tO\nthey\tO\nonly\tO\nthing\tO\nyou\tO\nget\tO\nout\tO\nof\tO\nthis\tO\nis\tO\nthe\tO\napple\tO\nname\tO\n.\tO\n\nMy\tO\nmac\tO\nlaptop\tO\nis\tO\nfabulous\tO\nin\tO\nboth\tO\nareas\tO\n.\tO\n\npros\tO\n:\tO\nthe\tO\nmacbook\tO\npro\tO\nnotebook\tO\nhas\tO\na\tO\nlarge\tO\nbattery\tO\nlife\tB-aspectTerm\nand\tO\nyou\tO\nwo\tO\nnt\tO\nhave\tO\nto\tO\nworry\tO\nto\tO\ncharge\tO\nyour\tO\nlaptop\tO\nevery\tO\nfive\tO\nhours\tO\nor\tO\nso\tO\n.\tO\n\nI\tO\nhighly\tO\nrecommend\tO\nthis\tO\nproduct\tO\n!\tO\n\nDisappointing\tO\nfor\tO\nsuch\tO\na\tO\nlovely\tO\nscreen\tB-aspectTerm\nand\tO\nat\tO\na\tO\nreasonable\tO\nprice\tB-aspectTerm\n\nSo\tO\nfar\tO\n,\tO\nit\tO\n's\tO\nan\tO\naverage\tO\nlaptop\tO\n-\tO\nno\tO\nbetter\tO\n,\tO\nno\tO\nworse\tO\nthan\tO\nthe\tO\nHP\tO\nI\tO\nreplaced\tO\n.\tO\n\nThe\tO\nonly\tO\nbad\tO\nthing\tO\nabout\tO\nit\tO\nis\tO\nthey\tO\ngive\tO\nyou\tO\nthe\tO\nworst\tO\nbatteries\tB-aspectTerm\npossible\tO\n.\tO\n\nGood\tO\nprice\tB-aspectTerm\n.\tO\n\nTHE\tO\nMOTHERBOARD\tO\nIS\tO\nDEAD\tO\n!\tO\n\nI\tO\nwanted\tO\nto\tO\nspend\tO\naround\tO\n$\tO\n700\tO\nto\tO\n$\tO\n800\tO\nso\tO\nI\tO\nwas\tO\ndirected\tO\nto\tO\na\tO\nnice\tO\nlooking\tO\nHP\tO\nLaptop\tO\n.\tO\n\nthe\tO\nspeed\tB-aspectTerm\nis\tO\nfine\tO\n.\tO\n\nI\tO\nwas\tO\nstarting\tO\nto\tO\nboil\tO\n.\tO\n\nHmmm\tO\n-\tO\nthat\tO\nhigh\tO\nfailure\tO\nrate\tO\nsure\tO\nis\tO\nn't\tO\nreflected\tO\nin\tO\nthe\tO\nretail\tB-aspectTerm\nprice\tI-aspectTerm\n.\tO\n\nBAck\tO\nshe\tO\ngoes\tO\n!\tO\n\nIt\tO\nwas\tO\nnot\tO\nclear\tO\nthat\tO\nthe\tO\nMicrosoft\tB-aspectTerm\nStudent\tI-aspectTerm\nEdition\tI-aspectTerm\nthat\tO\nwas\tO\nloaded\tO\non\tO\nthe\tO\ncomputer\tO\n,\tO\nwas\tO\na\tO\nsix\tO\nmonth\tO\ntrial\tO\n.\tO\n\nnot\tO\nthe\tO\nday\tO\nreceived\tO\n.\tO\n\nGood\tO\nfor\tO\nevery\tB-aspectTerm\nday\tI-aspectTerm\ncomputing\tI-aspectTerm\nand\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\n.\tO\n\nWhile\tO\nlacking\tO\nsome\tO\nof\tO\nthe\tO\nfunctions\tB-aspectTerm\nof\tO\nthe\tO\nother\tO\nversions\tO\n,\tO\nthis\tO\nwas\tO\nvery\tO\nacceptable\tO\nfor\tO\nthe\tO\nuses\tO\nplanned\tO\nfor\tO\nthis\tO\ncomputer\tO\n.\tO\n\nAlso\tO\n,\tO\nI\tO\nhave\tO\nhad\tO\nalot\tO\nof\tO\ntrouble\tO\nwith\tO\nthe\tO\nkeys\tO\nsticking\tB-aspectTerm\nand\tO\nwill\tO\nnot\tO\ntype\tO\ncorrectly\tO\n.\tO\n\nIt\tO\nstill\tO\nseems\tO\nto\tO\nbe\tO\na\tO\nlittle\tO\nlose\tO\nnow\tO\nbut\tO\nso\tO\nfar\tO\nseems\tO\nto\tO\nbe\tO\nhanging\tO\nin\tO\nthere\tO\n.\tO\n\nIt\tO\nis\tO\nby\tO\nfar\tO\none\tO\nof\tO\nthe\tO\ngreatest\tO\ninvestments\tO\nI\tO\nhave\tO\never\tO\nmade\tO\n.\tO\n\nIf\tO\nyou\tO\nare\tO\na\tO\nPC\tO\nuser\tO\nlooking\tO\nto\tO\nconvert\tO\nI\tO\nwould\tO\nHIGHLY\tO\nrecommend\tO\nit\tO\n!\tO\n\nExcellent\tO\nLED\tB-aspectTerm\nmonitor\tI-aspectTerm\nand\tO\nwell\tO\nequipped\tO\n.\tO\n\nThis\tO\nprocess\tO\ncontinued\tO\nto\tO\nrepeat\tO\nitself\tO\nuntil\tO\nthe\tO\nmother\tO\nboard\tB-aspectTerm\nhad\tI-aspectTerm\nbeen\tO\nreplaced\tO\n4\tO\ntimes\tO\nand\tO\nthe\tO\nhard\tO\ndrive\tB-aspectTerm\nreplaced\tI-aspectTerm\n3\tO\ntimes\tO\n.\tO\n\nWithout\tO\na\tO\ndoubt\tO\n,\tO\nthe\tO\n*\tO\ndesign\tB-aspectTerm\n*\tO\nof\tO\nthis\tO\nlaptop\tO\nis\tO\nfantastic\tO\n.\tO\n\nI\tO\ncould\tO\nn't\tO\nbelieve\tO\nhow\tO\nlong\tO\nthe\tO\nbattery\tB-aspectTerm\nlasted\tO\non\tO\na\tO\nsingle\tO\ncharge\tB-aspectTerm\n.\tO\n\nI\tO\ncould\tO\nsave\tO\nten\tO\nessay\tO\npapers\tO\nand\tO\nhave\tO\nhardly\tO\nany\tO\nmemory\tB-aspectTerm\nleft\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nmy\tO\nMacbook\tO\nPro\tO\nsince\tO\nAugust\tO\n2009\tO\n.\tO\n\nUnfortunately\tO\n,\tO\nthe\tO\nlaptop\tO\nI\tO\npurchased\tO\nwas\tO\nalso\tO\na\tO\nDell\tO\nand\tO\nagain\tO\n,\tO\nI\tO\nhave\tO\nto\tO\nsay\tO\ni\tO\nhated\tO\nit\tO\n.\tO\n\nTook\tO\na\tO\nwhile\tO\nto\tO\nclean\tO\nit\tO\nup\tO\nto\tO\nmy\tO\nspecs\tO\n.\tO\n\nThey\tO\nare\tO\nso\tO\nrealistic\tO\nI\tO\nam\tO\njust\tO\nspeechless\tO\n.\tO\n\nOther\tO\nthan\tO\nthat\tO\n,\tO\nI\tO\nwould\tO\nrecommend\tO\nthis\tO\nto\tO\nsomeone\tO\nin\tO\nneed\tO\nof\tO\na\tO\ncheap\tO\nlaptop\tO\nwith\tO\nsemi\tO\n-\tO\ndecent\tO\ngaming\tB-aspectTerm\ncapabilities\tO\n.\tO\n\nThis\tO\nis\tO\nthe\tO\nfirst\tO\ntime\tO\nthat\tO\nI\tO\ntried\tO\nand\tO\nowning\tO\na\tO\nnetbook\tO\nalthough\tO\nI\tO\nhave\tO\nused\tO\n3\tO\ndifferent\tO\nlaptops\tO\nin\tO\nthe\tO\npast\tO\n10\tO\nyears\tO\n,\tO\nI\tO\nfind\tO\nnot\tO\nmuch\tO\ndifference\tO\nexcept\tO\nof\tO\ncourse\tO\nfor\tO\nthe\tO\nscreen\tB-aspectTerm\nsize\tI-aspectTerm\n.\tO\n\nBut\tO\nthe\tO\nbiggest\tO\npain\tO\nis\tO\nthat\tO\ntech\tB-aspectTerm\nsupport\tI-aspectTerm\nis\tO\nnot\tO\navailable\tO\n24/7\tO\n.\tO\n\nThere\tO\nare\tO\ndifferences\tO\nthat\tO\nyou\tO\nneed\tO\nto\tO\nknow\tO\nand\tO\ntake\tO\ntime\tO\nto\tO\nlearn\tO\n.\tO\n\nThey\tO\nhave\tO\nmore\tO\nproblems\tO\nthen\tO\na\tO\n1980\tO\n's\tO\ncomputer\tO\n.\tO\n\nIt\tO\nis\tO\namazing\tO\n.\tO\n\nNeedless\tO\nto\tO\nsay\tO\n,\tO\nnot\tO\nto\tO\nhappy\tO\nwith\tO\nthe\tO\nproduct\tO\n.\tO\n\nThe\tO\ncool\tO\nthing\tO\nabout\tO\nthis\tO\nis\tO\nanyone\tO\ncan\tO\nuse\tO\nit\tO\n.\tO\n\nMy\tO\nfirst\tO\nlaptop\tO\nwas\tO\nan\tO\nAcer\tO\nthat\tO\nI\tO\ngot\tO\nfor\tO\nChristmas\tO\n.\tO\n\nStill\tO\n,\tO\nthis\tO\nlaptop\tO\nis\tO\nperfect\tO\nfor\tO\nall\tO\nday\tO\nuse\tO\nat\tO\nschool\tO\nand\tO\nwork\tO\n.\tO\n\nthe\tO\ninternet\tO\ncan\tO\nbe\tO\nan\tO\nscary\tO\nplace\tO\nits\tO\nup\tO\nto\tO\nyou\tO\non\tO\nwhat\tO\nyou\tO\ndo\tO\nwith\tO\nit\tO\n.\tO\n\nThe\tO\nbacklit\tB-aspectTerm\nkeys\tI-aspectTerm\nare\tO\nwonderful\tO\nwhen\tO\nyou\tO\nare\tO\nworking\tO\nin\tO\nthe\tO\ndark\tO\n.\tO\n\nI\tO\nchose\tO\nthe\tO\niBookG4\tO\n,\tO\na\tO\nlaptop\tO\nthat\tO\nis\tO\nan\tO\nattractive\tO\ncomputer\tO\nwith\tO\na\tO\nlarge\tO\nscreen\tB-aspectTerm\nbig\tO\nenough\tO\nto\tO\nplease\tO\nanyone\tO\n.\tO\n\nThe\tO\nmost\tO\nrecent\tO\nbeing\tO\nthat\tO\nmy\tO\nSafari\tB-aspectTerm\ninternet\tI-aspectTerm\nbrowser\tI-aspectTerm\nis\tO\nfreaking\tO\nout\tO\non\tO\nme\tO\n,\tO\nbut\tO\nI\tO\nhave\tO\njust\tO\nbeen\tO\nusing\tO\nfirefox\tB-aspectTerm\ninstead\tO\n.\tO\n\nI\tO\nwould\tO\nsay\tO\nif\tO\nyou\tO\nwant\tO\nto\tO\nbuy\tO\none\tO\nof\tO\nthese\tO\nmachines\tO\nbe\tO\ncareful\tO\n.\tO\n\nEverything\tO\nabout\tO\nthe\tO\nMac\tO\nis\tO\nnot\tO\nonly\tO\nvisually\tO\nappealing\tO\n,\tO\nbut\tO\nvery\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nI\tO\nknow\tO\nwhat\tO\n7\tO\nhrs\tO\nof\tO\nbattery\tB-aspectTerm\nlooks\tO\nlike\tO\n.\tO\n\nThe\tO\nMacbooks\tO\nworth\tO\nevery\tO\npenny\tO\n.\tO\n\nI\tO\ndid\tO\nnot\tO\nhave\tO\nto\tO\ncall\tO\nthe\tO\nsupport\tB-aspectTerm\nline\tI-aspectTerm\nat\tO\nall\tO\n.\tO\n\nThe\tO\nlaptop\tO\nis\tO\noutstanding\tO\nin\tO\nall\tO\naspects\tO\nexcept\tO\nthat\tO\nit\tO\nhas\tO\nthe\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nstarter\tI-aspectTerm\nand\tO\nnot\tO\nthe\tO\nfull\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\n.\tO\n\nTHE\tO\nFIRST\tO\nPROBLEM\tO\nIS\tO\nTHAT\tO\nTHE\tO\nKEYBOARD\tB-aspectTerm\nFUNCTION\tI-aspectTerm\nIS\tO\nSIMPLY\tO\nUNSATISFACTORY\tO\n.\tO\n\nThe\tO\nDVD\tB-aspectTerm\ndrive\tI-aspectTerm\nrandomly\tO\npops\tO\nopen\tO\nwhen\tO\nit\tO\nis\tO\nin\tO\nmy\tO\nbackpack\tO\nas\tO\nwell\tO\n,\tO\nwhich\tO\nis\tO\nannoying\tO\n.\tO\n\nGarageband\tB-aspectTerm\nis\tO\nmore\tO\nfor\tO\nthe\tO\nmusicians\tO\n,\tO\nand\tO\nthe\tO\nlaptop\tO\nis\tO\nequipped\tO\nwith\tO\na\tO\ngood\tO\nworking\tO\nmicrophone\tB-aspectTerm\n,\tO\ngood\tO\nenough\tO\nfor\tO\nbeginners\tO\nand\tO\nmusicians\tO\nat\tO\nthe\tO\nintermediate\tO\nlevel\tO\n.\tO\n\nI\tO\ndual\tO\nboot\tO\nwith\tO\nLinux\tB-aspectTerm\nand\tO\nthat\tO\nother\tO\nsecurity\tB-aspectTerm\n-\tI-aspectTerm\nprone\tI-aspectTerm\nOS\tI-aspectTerm\nand\tO\nit\tO\nperforms\tB-aspectTerm\nflawlessly\tO\n.\tO\n\nThe\tO\ndifference\tO\nis\tO\nthe\tO\nToshiba\tO\nhad\tO\na\tO\nlot\tO\nmore\tO\nmemory\tB-aspectTerm\nand\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nspace\tI-aspectTerm\n.\tO\n\nBut\tO\nif\tO\nyou\tO\nca\tO\nn't\tO\nmake\tO\nyour\tO\nproduct\tO\nlast\tO\nmore\tO\nthan\tO\na\tO\nyear\tO\n,\tO\nyou\tO\nwill\tO\nnot\tO\nget\tO\nmy\tO\nbusiness\tO\nagain\tO\n.\tO\n\nThere\tO\nwas\tO\na\tO\nlittle\tO\ndifficulty\tO\ndoing\tO\nthe\tO\nmigration\tO\nas\tO\nthe\tO\nfirewire\tB-aspectTerm\ncable\tI-aspectTerm\nsystem\tI-aspectTerm\nca\tO\nn't\tO\nbe\tO\nused\tO\nwith\tO\nthe\tO\niBook\tB-aspectTerm\n.\tO\n\nSeems\tO\nlike\tO\nmaybe\tO\na\tO\nbad\tO\nshipment\tB-aspectTerm\nfrom\tO\nToshiba\tO\n.\tO\n\nDo\tO\nn't\tO\nwaste\tO\nyour\tO\nmoney\tO\n!\tO\n\nCurrently\tO\nif\tO\nI\tO\nuse\tO\nthe\tO\nlaptop\tO\nI\tO\nca\tO\nn't\tO\nsit\tO\nit\tO\non\tO\nmy\tO\nlap\tO\nbecause\tO\nit\tO\nwill\tO\nburn\tO\nmy\tO\nlegs\tO\n.\tO\n\n-Managed\tO\nto\tO\nsend\tO\ncomplaint\tO\nemail\tO\n.\tO\n\nhowever\tO\n,\tO\nthey\tO\nwere\tO\nkind\tO\nenough\tO\nto\tO\nsend\tO\na\tO\nreplacement\tO\nfree\tO\nof\tO\ncharge\tO\n.\tO\n\nSeriously\tO\nconsidering\tO\na\tO\nlarger\tO\nlaptop\tO\nto\tO\nreplace\tO\nthe\tO\nDell\tO\n\nOS\tB-aspectTerm\nX\tI-aspectTerm\nis\tO\nsolid\tO\nwith\tO\nlots\tO\nof\tO\ninnovations\tO\nsuch\tO\nas\tO\nquicklook\tB-aspectTerm\nwhich\tO\nsave\tO\nheaps\tO\nof\tO\ntime\tO\n.\tO\n\nI\tO\ndo\tO\neverything\tO\non\tO\nthis\tO\ncomputer\tO\n-\tO\ncheck\tO\nemail\tO\n,\tO\nfacebook\tO\n,\tO\nshop\tO\n,\tO\ncheck\tO\nblogs\tO\n,\tO\nwrite\tO\npapers\tO\n,\tO\nlisten\tO\nto\tO\nmusic\tO\n,\tO\nand\tO\nwe\tO\neven\tO\nwatch\tO\nall\tO\nof\tO\nour\tO\nmovies\tO\non\tO\nit\tO\nsince\tO\nwe\tO\ndo\tO\nnot\tO\nhave\tO\na\tO\ntv\tO\n.\tO\n\nI\tO\nthought\tO\nit\tO\nwould\tO\nbe\tO\na\tO\nsimple\tO\njob\tO\n.\tO\n\nBut\tO\nother\tO\nthan\tO\nthat\tO\nI\tO\nam\tO\nblown\tO\naway\tO\nby\tO\nall\tO\nthe\tO\nfeatures\tB-aspectTerm\nthis\tO\nlaptop\tO\noffers\tO\n.\tO\n\nI\tO\nHate\tO\nit\tO\n!\tO\n\nDo\tO\nn't\tO\nbuy\tO\nthis\tO\nmodel\tO\n.\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\nis\tO\nslick\tO\nand\tO\nquiet\tO\nand\tO\nnot\tO\nbulky\tO\nlike\tO\nsome\tO\nother\tO\nlaptops\tO\nI\tO\nhave\tO\nhad\tO\nin\tO\nthe\tO\npast\tO\n.\tO\n\nI\tO\ncan\tO\nleave\tO\nmy\tO\nMacBook\tO\nuncharged\tO\nfor\tO\nupwards\tO\nof\tO\neight\tO\nhours\tO\nand\tO\nit\tO\nwo\tO\nn't\tO\neven\tO\nbe\tO\ndead\tO\n.\tO\n\nOverall\tO\n,\tO\nthis\tO\nlaptop\tO\nis\tO\ndefinitely\tO\na\tO\nkeeper\tO\nwith\tO\nits\tO\nsimple\tO\nyet\tO\nstylish\tO\ndesign\tB-aspectTerm\nand\tO\nits\tO\narray\tO\nof\tO\nfantastic\tO\ncolors\tB-aspectTerm\nto\tO\nchoose\tO\nfrom\tO\n.\tO\n\nI\tO\ndo\tO\nfind\tO\nthat\tO\nmy\tO\nMacBook\tO\nhas\tO\na\tO\nlot\tO\nmore\tO\nbells\tO\nand\tO\nwhistles\tO\nthan\tO\na\tO\nnormal\tO\nPC\tO\nespecially\tO\nif\tO\nyou\tO\nenjoy\tO\ntechnology\tO\n,\tO\ndownloading\tO\npictures\tO\nand\tO\ngraphic\tO\ndesign\tO\n.\tO\n\nFirst\tO\nthe\tO\nscreen\tB-aspectTerm\ngoes\tO\ncompletely\tO\nout\tO\n.\tO\n\nI\tO\n'm\tO\nlearning\tO\nthe\tO\nfinger\tO\noptions\tO\nfor\tO\nthe\tO\nmousepad\tB-aspectTerm\nthat\tO\nallow\tO\nfor\tO\nquicker\tO\nbrowsing\tB-aspectTerm\nof\tO\nweb\tO\npages\tO\n.\tO\n\nI\tO\nlove\tO\nthis\tO\n13\tO\n\"\tO\nMac\tO\nwhite\tO\nunibody\tO\n.\tO\n\nthe\tO\nlast\tO\ntime\tO\nwe\tO\ntook\tO\nit\tO\nto\tO\nget\tO\nfixed\tO\nthe\tO\nguy\tO\nsaid\tO\nthat\tO\nmost\tO\nlikely\tO\nit\tO\nis\tO\na\tO\nreppative\tO\nproblem\tO\nand\tO\nwill\tO\nkeep\tO\nhappeneing\tO\nso\tO\nhopefully\tO\nwe\tO\ncan\tO\nget\tO\na\tO\nnew\tO\none\tO\nvery\tO\nsoon\tO\n!\tO\n\nWhen\tO\nI\tO\nam\tO\nat\tO\nStarbucks\tO\nbetween\tO\nclients\tO\nI\tO\nget\tO\nfull\tO\nbars\tO\non\tO\nmy\tO\nHP\tO\nand\tO\n1\tO\nbar\tO\non\tO\nmy\tO\nEee\tO\nPC\tO\n.\tO\n\nThe\tO\nPhotoBooth\tB-aspectTerm\nis\tO\na\tO\ngreat\tO\nprogram\tB-aspectTerm\n,\tO\nit\tO\ntakes\tO\nvery\tO\ngood\tO\npictures\tO\nwith\tO\nthe\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\ncamera\tI-aspectTerm\n.\tO\n\nAnd\tO\ninconvenient\tO\n!\tO\n\nMany\tO\nkinds\tO\nof\tO\nsoftware\tB-aspectTerm\nthat\tO\nis\tO\nnecessary\tO\nto\tO\nthe\tO\nworking\tO\nperson\tO\nis\tO\nnot\tO\navailable\tO\nand\tO\ncan\tO\nnot\tO\nbe\tO\ndownloaded\tO\n.\tO\n\nIt\tO\nis\tO\nso\tO\nspeedy\tO\n.\tO\n\nNeeds\tO\nconstant\tO\nrepair\tO\n.\tO\n\nI\tO\nwill\tO\nnever\tO\npurchase\tO\na\tO\nHP\tO\nagain\tO\never\tO\n.\tO\n\nI\tO\nhad\tO\nto\tO\npay\tO\nfor\tO\nthe\tO\nshipping\tB-aspectTerm\n!\tO\n\nIt\tO\nbluescreened\tO\non\tO\nme\tO\nwithout\tO\nany\tO\nwarning\tO\n,\tO\nrunning\tO\nsimply\tO\nbasic\tO\nChrome\tB-aspectTerm\n.\tO\n\nThis\tO\nis\tO\nanother\tO\nreason\tO\nto\tO\nlike\tO\nthe\tO\nMac\tO\n.\tO\n\nI\tO\ntook\tO\n3\tO\n-\tO\n4\tO\nyears\tO\nresearching\tO\nbrands\tO\nand\tO\nprices\tB-aspectTerm\nof\tO\nlaptops\tO\n.\tO\n\nOne\tO\nbad\tO\nthing\tO\nis\tO\nit\tO\ngets\tO\nhot\tO\n.\tO\n\nI\tO\n'm\tO\nstuck\tO\nw/\tO\na\tO\nbroken\tO\ncomputer\tO\n.\tO\n\nWe\tO\nresearched\tO\nand\tO\nfound\tO\nthe\tO\nbest\tO\nprice\tB-aspectTerm\nat\tO\nMacConnection\tO\n.\tO\n\nHope\tO\nthis\tO\nhelps\tO\n!\tO\n\nBut\tO\nguess\tO\nwhat\tO\n?\tO\n(\tO\nyou\tO\nhave\tO\nto\tO\nbuy\tO\nan\tO\nexternal\tO\ndvd\tB-aspectTerm\ndrive\tI-aspectTerm\nit\tO\ndoes\tO\nn't\tO\nhave\tO\na\tO\nbuilt\tO\nin\tO\ntype\tO\n)\tO\nThe\tO\nnotebook\tO\nca\tO\nn't\tO\nbe\tO\nused\tO\nbecause\tO\nit\tO\ndoes\tO\nn't\tO\nread\tO\nanything\tO\nfor\tO\nan\tO\nexternal\tO\ndrive\tB-aspectTerm\n.\tI-aspectTerm\n\nGET\tO\nTHIS\tO\nCOMPUTER\tO\nFOR\tO\nPORTABILITY\tB-aspectTerm\nAND\tO\nFAST\tO\nPROCESSING\tB-aspectTerm\n!\tO\n!\tO\n!\tO\n\nApparently\tO\nthey\tO\n're\tO\nnot\tO\nspecial\tO\nanymore\tO\n.\tO\n\nI\tO\nuse\tO\na\tO\ncooling\tB-aspectTerm\npad\tI-aspectTerm\nbut\tO\nit\tO\ndoes\tO\nn't\tO\nhelp\tO\n.\tO\n\nI\tO\n'm\tO\nso\tO\nglad\tO\nI\tO\npurchased\tO\na\tO\nMac\tO\nand\tO\nnot\tO\nanother\tO\nPC\tO\n!\tO\n!\tO\n!\tO\n\n99\tO\nto\tO\nfix\tO\nit\tO\n.\tO\n\nFew\tO\nviruses\tO\nto\tO\ncatch\tO\n;\tO\n\nSupplied\tB-aspectTerm\nsoftware\tI-aspectTerm\n:\tO\nThe\tO\nsoftware\tB-aspectTerm\nthat\tO\ncomes\tO\nwith\tO\nthis\tO\nmachine\tO\nis\tO\ngreatly\tO\nwelcomed\tO\ncompared\tO\nto\tO\nwhat\tO\nWindows\tB-aspectTerm\ncomes\tO\nwith\tO\n.\tO\n\nSteve\tO\nJobs\tO\n,\tO\nprobably\tO\nneeds\tO\nhelp\tO\nand\tO\ndonations\tO\n,\tO\nand\tO\ncan\tO\nnot\tO\nafford\tO\na\tO\nreasonable\tO\noffers\tO\nfor\tO\npeople\tO\nthat\tO\ntruly\tO\nare\tO\ntrying\tO\nto\tO\nsupport\tO\nhis\tO\nbaby\tO\n.\tO\n\nI\tO\n'm\tO\ntired\tO\nof\tO\nthe\tO\ninept\tO\nservice\tB-aspectTerm\n.\tO\n\nGarageband\tB-aspectTerm\nis\tO\neasy\tO\nto\tO\nwork\tO\nwith\tO\n,\tO\nlike\tO\nall\tO\nthe\tO\nother\tO\napple\tB-aspectTerm\napplications\tI-aspectTerm\nI\tO\n've\tO\nhad\tO\nexperience\tO\nwith\tO\n.\tO\n\nNo\tO\n,\tO\ntey\tO\ndo\tO\nn't\tO\neven\tO\nsupport\tO\ntheir\tO\nown\tO\nbios\tB-aspectTerm\nand\tO\nit\tO\n\"\tO\ncould\tO\nbe\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\nbios\tB-aspectTerm\n\"\tO\nHow\tO\ncan\tO\na\tO\ncompany\tO\nthat\tO\nmakes\tO\na\tO\nfairly\tO\ndecent\tO\nproduct\tO\nget\tO\naway\tO\nwith\tO\nsuch\tO\ninsanity\tO\n?\tO\n?\tO\n!\tO\n!\tO\n\nWhile\tO\nmany\tO\npeople\tO\nbrag\tO\nabout\tO\nMac\tO\nbeing\tO\n\"\tO\nintuitive\tO\n\"\tO\n,\tO\nit\tO\ndoes\tO\ntake\tO\na\tO\nlittle\tO\ntime\tO\nto\tO\nadjust\tO\nto\tO\ncoming\tO\nfrom\tO\na\tO\nPC\tO\n,\tO\nbut\tO\nonce\tO\nI\tO\ngot\tO\nthe\tO\nhang\tO\nof\tO\nit\tO\n,\tO\nI\tO\ndo\tO\nn't\tO\nwant\tO\nto\tO\ngo\tO\nback\tO\n.\tO\n\nBecause\tO\nwe\tO\ndid\tO\nnot\tO\npurchase\tO\nthe\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\nin\tO\ntime\tO\n,\tO\nwe\tO\nare\tO\non\tO\nthe\tO\nhook\tO\nfor\tO\nthe\tO\nrepair\tO\n.\tO\n\nIt\tO\nstarted\tO\nout\tO\nby\tO\nrandomly\tO\nceasing\tO\nto\tO\ncharge\tB-aspectTerm\nwhen\tO\nit\tO\nwas\tO\nplugged\tO\nin\tO\n(\tO\nmousing\tO\nover\tO\nthe\tO\nbattery\tO\nicon\tO\nwould\tO\nread\tO\n,\tO\nfor\tO\nexample\tO\n,\tO\n\"\tO\n74\tO\n%\tO\n,\tO\nplugged\tO\nin\tO\n,\tO\nnot\tO\ncharging\tB-aspectTerm\n\"\tO\n)\tO\n,\tO\nrequiring\tO\nme\tO\nto\tO\nunplug\tO\nit\tO\nand\tO\nplug\tO\nit\tO\nback\tO\nin\tO\nseveral\tO\ntimes\tO\nto\tO\nget\tO\nit\tO\nto\tO\ncharge\tB-aspectTerm\n.\tO\n\nThis\tO\nlaptop\tO\nlooked\tO\nbrand\tO\nnew\tO\nand\tO\nwas\tO\nshipped\tB-aspectTerm\nvery\tO\nquickly\tO\n.\tO\n\nIf\tO\nyou\tO\nare\tO\nlooking\tO\nfor\tO\nsomething\tO\nreliable\tO\n,\tO\nthis\tO\nis\tO\nthe\tO\nlaptop\tO\nfor\tO\nyou\tO\n.\tO\n\nInfo\tO\n:\tO\nWindows\tB-aspectTerm\nfailed\tO\nto\tO\nload\tO\nbecause\tO\nthe\tO\nkernal\tB-aspectTerm\nis\tO\nmissing\tO\n,\tO\nor\tO\ncorrupt\tO\n.\tO\n\nThe\tO\ndisplay\tB-aspectTerm\non\tO\nthis\tO\ncomputer\tO\nis\tO\nthe\tO\nbest\tO\nI\tO\n've\tO\nseen\tO\nin\tO\na\tO\nvery\tO\nlong\tO\ntime\tO\n,\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nvery\tO\nlong\tO\nand\tO\nvery\tO\nconvienent\tO\n.\tO\n\nMost\tO\nlaptops\tO\nand\tO\nnotebooks\tO\nare\tO\ndifficult\tO\nto\tO\nkey\tO\non\tO\n.\tO\n\nWe\tO\ndid\tO\nn't\tO\nbecause\tO\nit\tO\nwas\tO\nalready\tO\nover\tO\n2,400\tO\ndollars\tO\n!\tO\n\nBut\tO\nthe\tO\nquality\tB-aspectTerm\n,\tO\nin\tO\ngeneral\tO\nwas\tO\nless\tO\nthan\tO\nthe\tO\nworth\tO\nof\tO\nthe\tO\ncheap\tO\nlaptop\tO\n.\tO\n\nIn\tO\nthe\tO\nfirst\tO\nmoth\tO\nof\tO\nowning\tO\nthis\tO\ncomputer\tO\nits\tO\nhardrive\tB-aspectTerm\nfailed\tO\nwhich\tO\nhad\tO\nto\tO\nbe\tO\nreplaced\tO\n.\tO\n\nIts\tO\nalso\tO\nFUN\tO\nto\tO\nuse\tB-aspectTerm\n!\tO\n\nThe\tO\ngraphics\tB-aspectTerm\nand\tO\nscreen\tB-aspectTerm\nare\tO\nstunning\tO\nand\tO\nalthough\tO\nI\tO\nwas\tO\na\tO\nPC\tO\nperson\tO\n,\tO\nI\tO\nwas\tO\nable\tO\nto\tO\nunderstand\tO\nhow\tO\nto\tO\nuse\tO\na\tO\nmac\tO\nfairly\tO\nquickly\tO\n.\tO\n\nWIth\tO\nthe\tO\nupgraded\tB-aspectTerm\nmemory\tI-aspectTerm\n,\tO\nthe\tO\nMacBook\tO\nPro\tO\nnever\tO\nhas\tO\nan\tO\nissue\tO\nrunning\tB-aspectTerm\nmany\tO\nmany\tO\napplications\tB-aspectTerm\nat\tO\nonce\tO\n!\tO\n\nSimple\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nand\tO\ngreat\tO\ngraphics\tB-aspectTerm\n.\tO\n\nIt\tO\nstill\tO\nserves\tO\nme\tO\nwell\tO\nboth\tO\nin\tO\nbusiness\tO\nand\tO\nhome\tO\nneeds\tO\n.\tO\n\nI\tO\nuse\tO\nmy\tO\nfriends\tO\nand\tO\nfamily\tO\n's\tO\n$\tO\n2000\tO\nlaptops\tO\nand\tO\nthey\tO\nare\tO\nfast\tO\nand\tO\nreliable\tO\nand\tO\nHP\tO\n,\tO\nwell\tO\n,\tO\nI\tO\n'll\tO\nnever\tO\nbuy\tO\nor\tO\nrecommend\tO\nan\tO\nHP\tO\nto\tO\nanyone\tO\n!\tO\n\nMy\tO\nMacBook\tO\nis\tO\nprobably\tO\nthe\tO\nbest\tO\ninvestment\tO\nI\tO\nhave\tO\never\tO\nmade\tO\n.\tO\n\nThe\tO\ninternet\tB-aspectTerm\nspeed\tI-aspectTerm\nis\tO\nspectacular\tO\n.\tO\n\nThey\tO\nclaim\tO\ncall\tB-aspectTerm\ncenter\tI-aspectTerm\nis\tO\nstill\tO\ndown\tO\n.\tO\n\nMac\tO\nalso\tO\nhas\tO\nmany\tO\napps\tB-aspectTerm\nand\tO\nprograms\tB-aspectTerm\nthat\tO\nare\tO\nquite\tO\ncheap\tO\nor\tO\nfree\tO\n.\tO\n\nIf\tO\nyou\tO\nshop\tO\naround\tO\nin\tO\nthe\tO\ncurrent\tO\nmarket\tO\nyou\tO\ncan\tO\nfind\tO\na\tO\nmuch\tO\nbetter\tO\ndeal\tO\n.\tO\n\nI\tO\ndroped\tO\nthis\tO\nonce\tO\nfrom\tO\nthetable\tO\nwhen\tO\nmy\tO\nbaby\tO\ngirl\tO\ngrabed\tO\nme\tO\none\tO\nday\tO\nand\tO\nIT\tO\nis\tO\nstill\tO\nworking\tO\nwith\tO\nNO\tO\nissues\tO\n!\tO\n\nYou\tO\nwill\tO\nlove\tO\nthis\tO\nmacbook\tO\nif\tO\nyou\tO\nchoose\tO\nto\tO\nbuy\tO\nit\tO\n.\tO\n\nMy\tO\nhouse\tO\nis\tO\nnow\tO\n100\tO\n%\tO\nMacbook\tO\n.\tO\n\nThey\tO\n're\tO\nnot\tO\nsafe\tO\n,\tO\nthey\tO\n're\tO\nnot\tO\ndurable\tO\n,\tO\nthey\tO\njust\tO\na\tO\nworthless\tO\n.\tO\n\nMy\tO\nhusband\tO\nuses\tO\nit\tO\nmostly\tO\nfor\tO\ngames\tB-aspectTerm\n,\tO\nemail\tO\nand\tO\nmusic\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nno\tO\nluck\tO\nwith\tO\nstaples\tO\nor\tO\nHP\tO\nto\tO\nresolve\tO\nthis\tO\nproblem\tO\n.\tO\n\nI\tO\njust\tO\ntook\tO\nthe\tO\nbroken\tO\ncords\tB-aspectTerm\ninto\tO\nthe\tO\nApple\tO\nstore\tO\nand\tO\nthey\tO\ngave\tO\nme\tO\nnew\tO\nones\tO\n.\tO\n\nMy\tO\nMac\tO\nis\tO\nmuch\tO\nmore\tO\nefficient\tO\nthan\tO\na\tO\nPC\tO\nso\tO\nit\tO\ndoes\tO\nnot\tO\nneed\tO\nthe\tO\nextra\tO\nbells\tO\nand\tO\nwhistles\tO\nto\tO\ncompete\tO\n.\tO\n\nIt\tO\nWORKS\tO\n!\tO\n\nYou\tO\njust\tO\nlose\tO\na\tO\ncustomer\tO\n.\tO\n\nI\tO\nve\tO\nhad\tO\nseveral\tO\ncalls\tO\nlasting\tO\nmore\tO\nthan\tO\nan\tO\nhour\tO\nwith\tO\npromises\tO\nto\tO\ncall\tO\nback\tO\n,\tO\nbut\tO\nthe\tO\nreturn\tO\ncalls\tO\nnever\tO\ncame\tO\n.\tO\n\nApparently\tO\nunder\tO\nthe\tO\nscreen\tB-aspectTerm\nthere\tO\nare\tO\n2\tO\nlittle\tO\nscrews\tO\nand\tO\nwhen\tO\nthe\tO\nscreen\tB-aspectTerm\ngets\tO\nmoved\tO\nback\tO\nand\tO\nforth\tO\n,\tO\nthey\tO\ncome\tO\nloose\tO\n.\tO\n\nBeing\tO\na\tO\nPC\tO\nuser\tO\nmy\tO\nwhole\tO\nlife\tO\n,\tO\nit\tO\n's\tO\ntaking\tO\na\tO\nbit\tO\nof\tO\ntime\tO\nto\tO\nadapt\tO\nto\tO\nthe\tO\nOS\tB-aspectTerm\nof\tO\na\tO\nMac\tO\nbut\tO\nI\tO\n'm\tO\nfinding\tO\nmy\tO\nway\tO\naround\tO\n.\tO\n\nThe\tO\ncomputer\tO\nwill\tO\nconstantly\tO\nbe\tO\ngetting\tO\nhot\tO\nand\tO\nburning\tO\nyour\tO\nleg\tO\nunless\tO\nyou\tO\ngo\tO\nthrough\tO\nthe\tO\nhassle\tO\nof\tO\ntaking\tO\noff\tO\nthe\tO\nentire\tO\nback\tO\nof\tO\nit\tO\njust\tO\nto\tO\nclean\tO\nout\tO\nthe\tO\nfan\tB-aspectTerm\n.\tO\n\nI\tO\nhave\tO\nin\tO\nthe\tO\npast\tO\ngotten\tO\nsuperfine\tO\nsandpaper\tO\nand\tO\n\"\tO\nfixed\tO\n\"\tO\nthe\tO\nedges\tB-aspectTerm\nby\tO\nrounding\tO\nthem\tO\noff\tO\n.\tO\n\nI\tO\nhate\tO\nit\tO\n!\tO\n\nreturned\tO\nit\tO\n.\tO\n\nDownfalls\tO\n:\tO\nsharp\tO\nedges\tB-aspectTerm\n.\tO\n\nIt\tO\nis\tO\na\tO\ncheap\tO\nthrow\tO\ntogether\tO\n.\tO\n\ni\tO\nneeded\tO\none\tO\nto\tO\nbe\tO\nable\tO\nto\tO\ncarry\tB-aspectTerm\nto\tO\nwork\tO\neveryday\tO\nand\tO\nthis\tO\none\tO\nseems\tO\nto\tO\nfit\tO\nall\tO\nof\tO\nthe\tO\ncriteria\tO\n.\tO\n\nI\tO\nwould\tO\nrecommend\tO\nMac\tO\n,\tO\nand\tO\ndo\tO\n,\tO\nto\tO\nanyone\tO\nlooking\tO\nto\tO\nbuy\tO\na\tO\nnew\tO\ncomputer\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\ngorgeous\tO\n-\tO\nyummy\tO\ngood\tO\n.\tO\n\nDid\tO\nI\tO\nmention\tO\neverything\tO\nabout\tO\nit\tO\n,\tO\nfrom\tO\nsize\tB-aspectTerm\nto\tO\nweight\tB-aspectTerm\nto\tO\nkeyboard\tB-aspectTerm\nscreams\tO\nBULK\tO\n?\tO\n\nCa\tO\nn't\tO\nwait\tO\nuntil\tO\nI\tO\ngo\tO\non\tO\nvacation\tO\nand\tO\ntake\tO\nit\tO\nwith\tO\nme\tO\n.\tO\n\nGood\tO\nbye\tO\nBLUE\tO\nSCREEN\tO\nand\tO\nCritical\tO\nerrors\tO\n!\tO\n!\tO\n!\tO\n!\tO\n\nI\tO\nhad\tO\nit\tO\nfour\tO\nmonths\tO\nwhen\tO\nmy\tO\ndisc\tB-aspectTerm\ndrive\tI-aspectTerm\nrefused\tO\nto\tO\nopen\tO\n.\tO\n\nSo\tO\n,\tO\nafter\tO\nApple\tO\nreplaced\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nI\tO\nenjoyed\tO\nanother\tO\n4\tO\nmonths\tO\nof\tO\nmy\tO\nnew\tO\ncomputer\tO\n,\tO\nuntil\tO\nit\tO\nfroze\tO\nthis\tO\nmorning\tO\n--\tO\ncompletely\tO\n.\tO\n\nOnce\tO\nagain\tO\n,\tO\nI\tO\nwas\tO\ntold\tO\nit\tO\nwas\tO\nthe\tO\nsuspicious\tO\npower\tO\nsupply\tB-aspectTerm\nproblem\tO\n.\tO\n\nIt\tO\neasily\tO\nfits\tO\ninto\tO\nmost\tO\ncomputer\tO\nbags\tO\nbut\tO\ndoes\tO\nn't\tO\nweigh\tO\ndown\tO\na\tO\nbackpack\tO\nor\tO\nsatchel\tO\nwhen\tO\nbeing\tO\ncarried\tO\nwith\tO\nspirals\tO\nand/or\tO\ntextbooks\tO\n.\tO\n\nThe\tO\nMacbook\tO\nstarts\tB-aspectTerm\nfast\tO\n,\tO\ndoes\tO\nn't\tO\ncrash\tO\n,\tO\nhas\tO\na\tO\nfantastic\tO\ndisplay\tB-aspectTerm\n,\tO\nis\tO\nsmall\tO\nand\tO\nlight\tO\n(\tO\nI\tO\nhave\tO\nthe\tO\n13.3\tO\n\"\tO\nmodel\tO\n)\tO\n,\tO\nand\tO\nis\tO\nn't\tO\nalways\tO\ncomplaining\tO\nabout\tO\nupdates\tO\n,\tO\nlost\tO\nconnections\tO\n,\tO\nerrors\tO\n,\tO\nblue\tO\nscreens\tO\n,\tO\netc\tO\n.\tO\n\nIt\tO\nwas\tO\nkind\tO\nof\tO\na\tO\nrebellion\tO\nagainst\tO\nPC\tO\nin\tO\nfact\tO\n,\tO\nand\tO\nI\tO\nam\tO\ncertainly\tO\nglad\tO\nI\tO\ndid\tO\n.\tO\n\nUnable\tO\nto\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nthis\tO\nbrand\tO\nnew\tO\nlaptop\tO\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nall\tO\nthe\tO\ndesign\tO\ntools\tO\non\tO\nPages\tB-aspectTerm\nand\tO\nKeynotes\tB-aspectTerm\nmakes\tO\nit\tO\nmuch\tO\neasier\tO\nto\tO\ncreate\tO\nprofessional\tO\nlooking\tO\ndocuments\tO\nand\tO\npresentations\tO\n.\tO\n\nI\tO\nactually\tO\nhad\tO\nthe\tO\nhard\tO\ndrive\tB-aspectTerm\nreplaced\tO\ntwice\tO\n,\tO\nthe\tO\nmother\tO\nboard\tB-aspectTerm\nonce\tO\n,\tO\nthe\tO\ndvd\tO\ndrive\tB-aspectTerm\ntwice\tO\n,\tO\nthen\tO\nthey\tO\nFINALLY\tO\nagreed\tO\nto\tO\nreplace\tO\nit\tO\n,\tO\n(\tO\nALL\tO\nOF\tO\nTHIS\tO\nIN\tO\nLESS\tO\nTHAN\tO\n1\tO\n1/2\tO\nYEARS\tO\n!\tO\n\nI\tO\nreally\tO\ndo\tO\nn't\tO\nlike\tO\nit\tO\n,\tO\nbut\tO\nI\tO\nam\tO\nstuck\tO\n.\tO\n\nThe\tO\nguy\tO\nthen\tO\nsaid\tO\nthat\tO\nif\tO\nI\tO\ninsist\tO\non\tO\nhaving\tO\nthe\tO\nhinge\tB-aspectTerm\ntightened\tO\n,\tO\nthey\tO\ncan\tO\ndo\tO\nit\tO\nfor\tO\nme\tO\nbut\tO\nI\tO\nhave\tO\nto\tO\naccept\tO\nthe\tO\ncondition\tO\nafter\tO\nthe\tO\n\"\tO\nrepair\tO\n\"\tO\n.\tO\n\nThe\tO\nport\tB-aspectTerm\nis\tO\nsecured\tO\nto\tO\nmotherboard\tB-aspectTerm\nso\tO\nwhen\tO\nthis\tO\nhappens\tO\nyou\tO\nca\tO\nn't\tO\nsee\tO\nthe\tO\nplug\tO\nat\tO\nall\tO\n,\tO\nit\tO\n's\tO\njust\tO\ngone\tO\n.\tO\n\n-Stay\tO\naway\tO\nfrom\tO\nMacHouse\tO\nAmsterdam\tO\n.\tO\n\nOnce\tO\nagain\tO\napple\tO\nstands\tO\nalone\tO\nat\tO\nthe\tO\ntop\tO\nof\tO\nthe\tO\ncharts\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nfeel\tO\nof\tO\nthe\tO\nkey\tB-aspectTerm\nboard\tI-aspectTerm\n,\tO\nas\tO\nwell\tO\nas\tO\nthe\tO\ntrackpad\tB-aspectTerm\n.\tO\n\nNow\tO\nI\tO\nhave\tO\nthe\tO\nbest\tO\nof\tO\nboth\tO\nworlds\tO\nwith\tO\nall\tO\nof\tO\nthe\tO\npower\tB-aspectTerm\nand\tO\nease\tB-aspectTerm\nof\tO\nthe\tO\nMac\tO\n!\tO\n\nThese\tO\nnew\tO\nproblems\tO\nwere\tO\nthe\tO\nfinal\tO\nstraws\tO\n;\tO\n\nluckly\tO\ni\tO\nhad\tO\na\tO\nstudent\tO\ntask\tO\nforce\tO\nable\tO\nto\tO\nhelp\tO\n,\tO\nor\tO\nelse\tO\nit\tO\nwould\tO\nhave\tO\ncrashed\tO\nwithin\tO\nthe\tO\nfirst\tO\nyear\tO\n.\tO\n\nThat\tO\nseemed\tO\nto\tO\nsolve\tO\nthe\tO\nproblem\tO\n,\tO\ntill\tO\nI\tO\nwrote\tO\nan\tO\narticle\tO\nwith\tO\nsemicolons\tO\nin\tO\nit\tO\n.\tO\n\nEase\tO\nof\tO\nuse\tB-aspectTerm\nis\tO\njust\tO\none\tO\nof\tO\nthe\tO\nbenefits\tO\nI\tO\nlove\tO\nabout\tO\nmy\tO\nMac\tO\n.\tO\n\n-Touchpad\tO\nwill\tO\ntake\tO\na\tO\nbit\tO\nof\tO\ntime\tO\nto\tO\nget\tO\nused\tO\nto\tO\n.\tO\n\nWe\tO\nboth\tO\nrecently\tO\ngot\tO\nnew\tO\nlaptops\tO\n.\tO\n\nI\tO\n've\tO\nbeen\tO\na\tO\nPC\tO\nuser\tO\nand\tO\nI\tO\njust\tO\nfinally\tO\nswitched\tO\nand\tO\nI\tO\nam\tO\nnever\tO\ngoing\tO\nback\tO\n.\tO\n\nI\tO\ngot\tO\nthe\tO\nMacbook\tO\nand\tO\nhe\tO\ngot\tO\na\tO\nMacbook\tO\nPro\tO\n.\tO\n\nWinters\tO\nis\tO\non\tO\nit\tO\n's\tO\nway\tO\nand\tO\nI\tO\nimagine\tO\nit\tO\nwill\tO\nbe\tO\ncozy\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\nabout\tO\na\tO\nmonth\tO\nago\tO\nto\tO\nreplace\tO\nmy\tO\ncompaq\tO\nlaptop\tO\n.\tO\n\nNow\tO\nthe\tO\nmachine\tO\nwo\tO\nn't\tO\nconnect\tO\nand\tO\nToshiba\tO\nsays\tO\nthat\tO\nthey\tO\ndid\tO\nreplace\tO\nthe\tO\nconnection\tB-aspectTerm\ncard\tI-aspectTerm\nin\tO\nMay\tO\nbut\tO\nthey\tO\nonly\tO\nwarranty\tB-aspectTerm\nthe\tO\nrepair\tO\nfor\tO\n30\tO\ndays\tO\nand\tO\nnow\tO\nI\tO\n'm\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\neven\tO\nthough\tO\nthis\tO\nhas\tO\nbeen\tO\na\tO\nconstant\tO\n5\tO\nmonth\tO\noccurance\tO\nsince\tO\nI\tO\nbought\tO\nthe\tO\nnetbook\tO\n.\tO\n\nWill\tO\ncertainly\tO\nuse\tO\nMacConnection\tO\nagain\tO\n.\tO\n\nBut\tO\n,\tO\nbuy\tO\nthis\tO\nmodel\tO\nand\tO\njust\tO\npurchase\tO\n4\tB-aspectTerm\nGB\tI-aspectTerm\nof\tI-aspectTerm\nRAM\tI-aspectTerm\n(\tO\n2x2\tO\nGB\tO\nfor\tO\n$\tO\n92\tO\nor\tO\n1x4\tO\nGB\tO\nfor\tO\n$\tO\n99\tO\n)\tO\n,\tO\nand\tO\nsave\tO\nyourself\tO\n$\tO\n100\tO\nthan\tO\nthe\tO\nother\tO\nmodel\tO\nwith\tO\n8\tB-aspectTerm\nGB\tI-aspectTerm\nof\tI-aspectTerm\nRAM\tI-aspectTerm\n.\tO\n\nthis\tO\nis\tO\none\tO\nof\tO\nthe\tO\nreasons\tO\nI\tO\npurchased\tO\nit\tO\n.\tO\n\nInstead\tO\nof\tO\ntaking\tO\nanother\tO\nchance\tO\non\tO\nToshiba\tO\n,\tO\nI\tO\nwent\tO\nwith\tO\nan\tO\nAsus\tO\nG73JH\tO\n-\tO\nx3\tO\n.\tO\n\nShe\tO\ntold\tO\nme\tO\nflatly\tO\n,\tO\n\"\tO\nIt\tO\n's\tO\nlike\tO\nthat\tO\none\tO\n.\tO\n\nIf\tO\nyou\tO\n're\tO\nlooking\tO\nfor\tO\nsomething\tO\nto\tO\nfly\tO\nthrough\tO\nthose\tO\nmassive\tO\nspreadsheets\tO\nor\tO\nplay\tO\na\tO\ngraphics\tO\n-\tO\nintensive\tO\ngame\tB-aspectTerm\n,\tO\nyou\tO\n'd\tO\nbe\tO\nbetter\tO\noff\tO\ngetting\tO\na\tO\nmachine\tO\naimed\tO\nat\tO\nthat\tO\nsegment\tO\nof\tO\nthe\tO\nmarket\tO\n.\tO\n\nIt\tO\nis\tO\nthe\tO\neasiest\tO\ncomputer\tO\nI\tO\nhave\tO\never\tO\nused\tO\n\nSo\tO\nyou\tO\nmight\tO\nask\tO\n,\tO\nwhat\tO\ndid\tO\nApple\tO\ndo\tO\nfor\tO\nme\tO\n?\tO\n\nBrowsing\tB-aspectTerm\n,\tO\nalso\tO\n,\tO\nwas\tO\nno\tO\nproblem\tO\nfor\tO\nme\tO\nwhen\tO\nI\tO\nused\tO\nitunes\tB-aspectTerm\n(\tO\nwhich\tO\nusually\tO\nslows\tO\ndown\tO\nmy\tO\nPC\tO\n)\tO\n.\tO\n\nShould\tO\nbe\tO\nthere\tO\nby\tO\nthe\tO\nend\tO\nof\tO\nthe\tO\nweek\tO\n(\tO\nagain\tO\n...\tO\n)\tO\n.\tO\n\nAgain\tO\n,\tO\ndecent\tO\ncomp\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n,\tO\nand\tO\nI\tO\nwas\tO\nin\tO\nneed\tO\nof\tO\none\tO\nquickly\tO\nas\tO\nmy\tO\nother\tO\nlaptop\tO\ndied\tO\non\tO\nme\tO\n.\tO\n\nso\tO\nin\tO\na\tO\nbrief\tO\nsummary\tO\ni\tO\nwould\tO\nhave\tO\nto\tO\nsay\tO\nthat\tO\ni\tO\nwould\tO\nnot\tO\nrecommend\tO\ndell\tO\nvostro\tO\n1000\tO\nto\tO\nanyone\tO\ndue\tO\nto\tO\nit\tO\nbeing\tO\na\tO\ndown\tO\nright\tO\nawful\tO\nsetup\tB-aspectTerm\nso\tO\nin\tO\nmy\tO\nopinion\tO\nyou\tO\nshould\tO\nsteer\tO\nclear\tO\nof\tO\nthem\tO\nif\tO\nyou\tO\nwant\tO\na\tO\ndecent\tO\nlaptop\tO\n.\tO\n\nI\tO\njust\tO\ngot\tO\nthis\tO\nlaptop\tO\nfor\tO\ncollege\tO\n,\tO\nand\tO\nso\tO\nfar\tO\nI\tO\nam\tO\nvery\tO\nhappy\tO\nwith\tO\nit\tO\n.\tO\n\ntosiba\tO\nhas\tO\na\tO\ngood\tO\nreputation\tO\n,\tO\nmy\tO\nllast\tO\ncomputer\tO\nwas\tO\nan\tO\nacer\tO\n.\tO\n\nMy\tO\nfriend\tO\njust\tO\nhad\tO\nto\tO\nreplace\tO\nhis\tO\nentire\tO\nmotherboard\tB-aspectTerm\n,\tO\nso\tO\ndid\tO\nmy\tO\nwife\tO\n,\tO\nand\tO\nit\tO\nlooks\tO\nlike\tO\nI\tO\nwill\tO\nhave\tO\nto\tO\nas\tO\nwell\tO\n.\tO\n\nToshiba\tO\ncustomer\tB-aspectTerm\nservices\tI-aspectTerm\nwill\tI-aspectTerm\nindirectly\tO\ndeal\tO\nwith\tO\nyour\tO\nproblems\tO\nby\tO\nconstantly\tO\ntranferring\tO\nyou\tO\nfrom\tO\none\tO\ncountry\tO\nto\tO\nanother\tO\n,\tO\nand\tO\nI\tO\nam\tO\nnot\tO\nkidding\tO\nyou\tO\n,\tO\nI\tO\ncalled\tO\ndifferent\tO\nhours\tO\nof\tO\nthe\tO\nday\tO\nand\tO\nyou\tO\n'll\tO\nget\tO\nsomeone\tO\nelse\tO\nfrom\tO\nanother\tO\ncountry\tO\ntrying\tO\nto\tO\nget\tO\nyou\tO\nto\tO\ntell\tO\nthem\tO\nyour\tO\nlife\tO\nstory\tO\nall\tO\nover\tO\nagain\tO\n,\tO\nsince\tO\nthey\tO\nmake\tO\nit\tO\nsound\tO\nlike\tO\nthey\tO\ndo\tO\nn't\tO\nhave\tO\nyour\tO\nhistory\tO\nlist\tO\nof\tO\nyour\tO\ncalls\tO\nright\tO\nin\tO\nfront\tO\nof\tO\nthem\tO\n.\tO\n\nQuality\tB-aspectTerm\nDisplay\tI-aspectTerm\nI\tO\nwas\tO\nsurprised\tO\nwith\tO\nthe\tO\nperformance\tO\nand\tO\nquality\tO\nof\tO\nthis\tO\nHP\tO\nLaptop\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nalso\tO\ndoes\tO\nn't\tO\nkeep\tO\nup\tO\nwith\tO\nthe\tO\nclaim\tO\nbut\tO\nstill\tO\nI\tO\nthink\tO\nmacbook\tO\nis\tO\nmuch\tO\nahead\tO\nfrom\tO\nthe\tO\nrest\tO\nof\tO\nthe\tO\npack\tO\n.\tO\n\nThe\tO\ninternet\tB-aspectTerm\ncapabilities\tI-aspectTerm\nare\tO\nalso\tO\nvery\tO\nstrong\tO\nand\tO\npicks\tO\nup\tO\nsignals\tO\nvery\tO\neasily\tO\n.\tO\n\nIts\tO\nfast\tO\n,\tO\nhas\tO\nHigh\tB-aspectTerm\ndefinition\tI-aspectTerm\nquality\tI-aspectTerm\nin\tO\nthe\tO\nvideos\tO\n.\tO\n\nThey\tO\ntransfer\tO\nyou\tO\naround\tO\nto\tO\nother\tO\npeople\tO\nwho\tO\ndo\tO\nnot\tO\nunderstand\tO\nwhat\tO\nyou\tO\nare\tO\nsaying\tO\nand\tO\nyou\tO\nca\tO\nn't\tO\nunderstand\tO\nwhat\tO\nthey\tO\nare\tO\nsaying\tO\n.\tO\n\nSpeakers\tB-aspectTerm\ndo\tO\nn't\tO\nget\tO\nthat\tO\nloud\tO\n,\tO\nbut\tO\ngood\tO\nenough\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nit\tO\n9\tO\nmonths\tO\nand\tO\nit\tO\nis\tO\nalready\tO\na\tO\n$\tO\n250\tO\nloss\tO\n.\tO\n\nAnother\tO\nGreat\tO\nthing\tO\nis\tO\nthe\tO\nBeast\tB-aspectTerm\ngraphics\tI-aspectTerm\n.\tO\n\nI\tO\nwas\tO\nWRONG\tO\n!\tO\n\nThe\tO\nease\tO\nof\tO\nset\tB-aspectTerm\nup\tI-aspectTerm\nwas\tO\nterrific\tO\n.\tO\n\nEverything\tO\nI\tO\nhave\tO\ntried\tO\nhas\tO\nworked\tO\nand\tO\nI\tO\nnever\tO\nhave\tO\nto\tO\ncarry\tO\nthe\tO\nwall\tB-aspectTerm\ncharger\tI-aspectTerm\ncause\tO\nthe\tO\nbattery\tB-aspectTerm\nis\tO\nso\tO\nawesome\tO\n.\tO\n\nScreen\tB-aspectTerm\nis\tO\ncrystal\tO\nclear\tO\n,\tO\nyes\tO\nit\tO\n's\tO\nsmall\tO\n-\tO\nbut\tO\nit\tO\n's\tO\na\tO\nnetbook\tO\n!\tO\n\nSo\tO\nthis\tO\nreview\tO\nmight\tO\nbe\tO\na\tO\ntad\tO\nbit\tO\nbias\tO\n.\tO\n\nThis\tO\nwas\tO\naround\tO\nthree\tO\nyears\tO\n,\tO\nmaybe\tO\nfour\tO\nyears\tO\nago\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nprobably\tO\nan\tO\nhour\tO\nat\tO\nbest\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\nreview\tO\nof\tO\nwindows\tB-aspectTerm\nvista\tI-aspectTerm\nsystem\tI-aspectTerm\n.\tO\n\nShe\tO\nsaid\tO\nits\tO\nvery\tO\nuser\tO\nfriendly\tO\n.\tO\n\nKind\tO\nof\tO\nannoying\tO\n,\tO\nbut\tO\nI\tO\nstill\tO\nlove\tO\nthe\tO\nlaptop\tO\n.\tO\n\ncosmetically\tO\n,\tO\nthe\tO\nonly\tO\nthing\tO\nthey\tO\nchanged\tO\nwas\tO\n2\tO\nof\tO\nthe\tO\nFunction\tB-aspectTerm\nkeys\tI-aspectTerm\nat\tO\nthe\tO\ntop\tO\n.\tO\n\nI\tO\nam\tO\nvery\tO\nhappy\tO\nI\tO\nbought\tO\nthis\tO\nMac\tO\n,\tO\nwell\tO\nworth\tO\nthe\tO\nextra\tO\nmoney\tO\n.\tO\n\nBut\tO\nsadly\tO\nthe\tO\nreplacement\tO\nfroze\tO\n-\tO\nup\tO\nwhile\tO\nupdating\tO\nthe\tO\nBIOS\tB-aspectTerm\nagain\tO\nand\tO\nshut\tO\ndown\tO\nand\tO\nwould\tO\nnot\tO\nturn\tO\nback\tO\non\tO\n.\tO\n\nThere\tO\n's\tO\nliterally\tO\nno\tO\nway\tO\nto\tO\nmake\tO\nit\tO\nsing\tO\nwith\tO\nVista\tO\n.\tB-aspectTerm\n\nAfter\tO\nlooking\tO\nat\tO\nall\tO\nthe\tO\npros\tO\nand\tO\ncons\tO\n,\tO\nI\tO\ndecided\tO\non\tO\nthe\tO\nMacbook\tO\nPro\tO\n.\tO\n\nScreen\tB-aspectTerm\nsize\tI-aspectTerm\nis\tO\nperfect\tO\nfor\tO\nportable\tO\nuse\tO\nin\tO\nany\tO\nenvironment\tO\n.\tO\n\nFirst\tO\n,\tO\nit\tO\ndoes\tO\nnot\tO\nhave\tO\na\tO\npush\tB-aspectTerm\nbutton\tI-aspectTerm\nto\tO\nopen\tO\nthe\tO\nlid\tB-aspectTerm\n.\tO\n\nHope\tO\nthis\tO\nhelped\tO\n!\tO\n\nI\tO\nused\tO\nto\tO\nbuild\tO\nmy\tO\nown\tO\ndesktops\tO\nfrom\tO\nthe\tO\ncomponent\tO\nparts\tO\n,\tO\nand\tO\nrecently\tO\nmy\tO\n7\tO\nyear\tO\nold\tO\nPentium\tB-aspectTerm\n4\tI-aspectTerm\nwith\tO\nHT\tO\n1\tB-aspectTerm\nGB\tI-aspectTerm\nram\tI-aspectTerm\nSATA\tO\ndesktop\tO\nstopped\tO\nworking\tO\n(\tO\nthis\tO\nwas\tO\na\tO\nrock\tO\nstar\tO\n7\tO\nyears\tO\nago\tO\n)\tO\n.\tO\n\nI\tO\nnow\tO\nrealize\tO\nthat\tO\nmy\tO\n$\tO\n900\tO\nwould\tO\nhave\tO\nbeen\tO\nbetter\tO\nspent\tO\non\tO\na\tO\nWindows\tB-aspectTerm\nlaptop\tO\n.\tO\n\nPlease\tO\n,\tO\nanyone\tO\nwho\tO\nis\tO\nconsidering\tO\ngetting\tO\nthis\tO\ncomputer\tO\n,\tO\nstop\tO\n.\tO\n\nThis\tO\nlaptop\tO\nserves\tO\nall\tO\nmy\tO\nneeds\tO\n.\tO\n\n)\tO\nAnd\tO\nprinting\tO\nfrom\tO\neither\tO\nword\tB-aspectTerm\nprocessor\tI-aspectTerm\nis\tO\nan\tO\nadventure\tO\n.\tO\n\nVery\tO\nsatisfied\tO\n.\tO\n\nDo\tO\nnot\tO\nbuy\tO\nit\tO\n!\tO\n\n-Estimated\tO\ntime\tO\nto\tO\nfix\tO\nit\tO\n:\tO\n10\tO\nworking\tO\ndays\tO\nor\tO\nless\tO\n.\tO\n\nAfter\tO\npurchasing\tO\nthis\tO\nthing\tO\n,\tO\nI\tO\nfind\tO\nout\tO\nthat\tO\nI\tO\nneed\tO\na\tO\nspecial\tO\ninterface\tB-aspectTerm\ndevice\tI-aspectTerm\nto\tO\nconnect\tO\nmy\tO\ncamera\tO\n,\tO\nand\tO\nthat\tO\nit\tO\ncan\tO\nnot\tO\nbe\tO\npurchased\tO\nat\tO\nthe\tO\nstore\tO\n-\tO\nonly\tO\non\tO\nline\tO\n.\tO\n\nI\tO\nhad\tO\nmy\tO\ncomputer\tO\ncustom\tO\nbuilt\tO\nfrom\tO\nSonystyle.com\tO\n.\tO\n\nAnother\tO\nincluded\tB-aspectTerm\nprogram\tI-aspectTerm\nthat\tO\nis\tO\nlaughable\tO\nis\tO\nthe\tO\nchess\tO\ngame\tO\n.\tO\n\nYes\tO\n,\tO\nI\tO\nthought\tO\nthe\tO\nexpese\tB-aspectTerm\nwas\tO\na\tO\nlittle\tO\nmuch\tO\n,\tO\nbut\tO\nI\tO\nnow\tO\nrealize\tO\nyou\tO\nget\tO\nwhat\tO\nyou\tO\npay\tO\nfor\tO\n.\tO\n\nIt\tO\nworks\tO\ngreat\tO\nfor\tO\ngeneral\tO\ninternet\tB-aspectTerm\nuse\tI-aspectTerm\n,\tO\nMicrosoft\tB-aspectTerm\nOffice\tI-aspectTerm\napps\tI-aspectTerm\n,\tO\nhome\tO\nbookkeeping\tO\n,\tO\netc\tO\n.\tO\n\nI\tO\nwill\tO\nnot\tO\nbuy\tO\nanother\tO\none\tO\n.\tO\n\nTime\tO\nwill\tO\ntell\tO\n.\tO\n\nThe\tO\nprice\tB-aspectTerm\nwas\tO\nvery\tO\ngood\tO\n,\tO\nand\tO\nthe\tO\nproduct\tO\nis\tO\ntop\tO\nquality\tB-aspectTerm\n.\tO\n\nThis\tO\ncomputer\tO\nis\tO\nreally\tO\nfast\tO\nand\tO\nI\tO\n'm\tO\nshocked\tO\nas\tO\nto\tO\nhow\tO\neasy\tO\nit\tO\nis\tO\nto\tO\nget\tO\nused\tO\nto\tO\n...\tO\n\nIt\tO\nplayed\tO\nvarious\tO\ngames\tB-aspectTerm\nwithout\tO\nproblems\tO\nand\tO\nran\tO\naero\tB-aspectTerm\nsmoothly\tO\nand\tO\nflawlessly\tO\n.\tO\n\nAfter\tO\nreplacing\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nthe\tO\nbattery\tB-aspectTerm\nstopped\tO\nworking\tO\n(\tO\n3\tO\nmonths\tO\nof\tO\nuse\tO\n)\tO\nwhich\tO\nwas\tO\nfrustrating\tO\n.\tO\n\nThe\tO\nscreen\tO\nalmost\tB-aspectTerm\nlooked\tO\nlike\tO\na\tO\nbarcode\tO\nwhen\tO\nit\tO\nfroze\tO\n.\tO\n\nI\tO\nhave\tO\nfound\tO\na\tO\nlot\tO\nof\tO\nonline\tO\nsources\tO\nto\tO\nhelp\tO\nme\tO\nbut\tO\nthink\tO\nthat\tO\nI\tO\nwould\tO\nhave\tO\nlearned\tO\na\tO\nlot\tO\nquicker\tO\nif\tO\nI\tO\nwould\tO\nhave\tO\ntaken\tO\nthe\tO\nclass\tO\n.\tO\n\nFrom\tO\nthe\tO\nget\tO\n-\tO\ngo\tO\n,\tO\nthe\tO\nM6809\tO\nwas\tO\nunsteady\tO\nin\tO\nits\tO\noperation\tB-aspectTerm\n;\tO\n\nShe\tO\ntells\tO\nme\tO\nabout\tO\nit\tO\nall\tO\nthe\tO\ntime\tO\nbut\tO\nI\tO\ntend\tO\nto\tO\nshut\tO\noff\tO\nall\tO\ncognitive\tO\nfunctions\tO\nwhen\tO\nshe\tO\ngets\tO\nthat\tO\nyapper\tO\ngoing\tO\n.\tO\n\nI\tO\ncould\tO\nnot\tO\neven\tO\nput\tO\nmy\tO\nentire\tO\nmusic\tO\ncollection\tO\non\tO\nthis\tO\ngarabage\tO\n.\tO\n\nOne\tO\nof\tO\nthe\tO\nwonderful\tO\nthings\tO\nabout\tO\nMacs\tO\nis\tO\nthat\tO\nthey\tO\nare\tO\nvirus\tO\nfree\tO\n.\tO\n\nIts\tO\nsmall\tO\nenough\tO\nwhere\tO\nI\tO\ncan\tO\ntake\tO\nit\tO\npretty\tO\nmuch\tO\nanywhere\tO\n,\tO\nbut\tO\nstill\tO\nhas\tO\na\tO\nbig\tO\nenough\tO\nscreen\tB-aspectTerm\nto\tO\nget\tO\neverything\tO\ndone\tO\n.\tO\n\nIt\tO\neven\tO\nhas\tO\na\tO\ngreat\tO\nwebcam\tB-aspectTerm\n,\tO\nand\tO\nSkype\tB-aspectTerm\nworks\tO\nvery\tO\nwell\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nsolid\tO\nmachined\tB-aspectTerm\naluminum\tI-aspectTerm\nframe\tI-aspectTerm\n,\tO\nand\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\nthe\tO\nbest\tO\nof\tO\nany\tO\nlaptop\tO\nI\tO\n've\tO\nused\tO\n.\tO\n\nYou\tO\ncan\tO\neven\tO\nrun\tO\na\tO\nparallels\tB-aspectTerm\ntype\tI-aspectTerm\nprogram\tI-aspectTerm\neasily\tO\nand\tO\nrun\tO\nany\tO\nleftover\tO\nPC\tO\nsoftware\tB-aspectTerm\nthat\tO\nyou\tO\nabsolutely\tO\ncan\tO\nnot\tO\nbe\tO\nwithout\tO\n.\tO\n\nThis\tO\ncomputer\tO\nI\tO\nused\tO\ndaily\tO\nnice\tO\ncompact\tO\ndesign\tB-aspectTerm\n.\tO\n\nThe\tO\nATI\tB-aspectTerm\ngraphics\tI-aspectTerm\ncard\tI-aspectTerm\nis\tO\na\tO\nhuge\tO\nplus\tO\n,\tO\ndefinitely\tO\na\tO\ngood\tO\nvalue\tO\nif\tO\nyou\tO\nneed\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nrun\tO\nsome\tO\nslightly\tO\nolder\tO\ngames\tB-aspectTerm\nthat\tO\na\tO\nIntel\tB-aspectTerm\nbuilt\tI-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\ncard\tI-aspectTerm\nwould\tO\nhave\tO\ntrouble\tO\nwith\tO\n,\tO\nsuch\tO\nas\tO\nHalf\tO\n-\tO\nLife\tO\n2\tO\nor\tO\neven\tO\nWorld\tO\nof\tO\nWarcraft\tO\n.\tO\n\nI\tO\npractically\tO\nhave\tO\na\tO\nnew\tO\nlaptop\tO\nwith\tO\nall\tO\nthe\tO\n\"\tO\nfixes\tO\n\"\tO\nthey\tO\nhave\tO\ndone\tO\n!\tO\n\nFinally\tO\n,\tO\nI\tO\npurchased\tO\na\tO\nToshiba\tO\n.\tO\n\nIt\tO\nwas\tO\nhard\tO\nto\tO\nhandle\tB-aspectTerm\nand\tO\noperate\tB-aspectTerm\nat\tO\nschool\tO\n.\tO\n\nYou\tO\nmay\tO\njust\tO\nlose\tO\n1\tO\ncustomer\tO\nfor\tO\nnow\tO\n.\tO\n\nIt\tO\nhas\tO\neasy\tO\nto\tO\nuse\tO\nfeatures\tB-aspectTerm\nand\tO\nall\tO\nthe\tO\nspeed\tB-aspectTerm\nand\tO\npower\tB-aspectTerm\nI\tO\ncould\tO\nask\tO\nfor\tO\n.\tO\n\nMy\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\ncord\tI-aspectTerm\ndeveloped\tO\nexposed\tO\nwires\tO\nwithin\tO\nthe\tO\nfirst\tO\nyear\tO\nof\tO\nownership\tO\n,\tO\nso\tO\nit\tO\nwas\tO\ncovered\tO\nby\tO\nthe\tO\nApplecare\tB-aspectTerm\nwarranty\tI-aspectTerm\nplan\tI-aspectTerm\n.\tO\n\nMany\tO\nthanks\tO\n,\tO\nOverstock.com\tO\n.\tO\n\nI\tO\nlove\tO\nit\tO\nand\tO\nthe\tO\nchange\tO\nin\tO\nlifestyle\tO\nthat\tO\ncame\tO\nwith\tO\nit\tO\n.\tO\n\n)\tO\nonly\tO\nto\tO\nget\tO\nanother\tO\n\"\tO\nHP\tO\n/\tO\nCompaq\tO\n\"\tO\npiece\tO\nof\tO\ncrap\tO\n.\tO\n\nI\tO\npreferred\tO\nthe\tO\nfit\tO\nand\tO\nfeel\tO\nof\tO\nthe\tO\n13\tB-aspectTerm\ninch\tI-aspectTerm\n.\tO\n\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nwent\tO\nbad\tO\nafter\tO\n2\tO\nweeks\tO\n--\tO\n\nEmachines\tO\nsays\tO\nthey\tO\n're\tO\nwaiting\tO\nfor\tO\na\tO\npart\tO\nand\tO\nrefuses\tO\nto\tO\nreplace\tO\nentire\tO\nunit\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\ntakes\tO\nsome\tO\ngetting\tO\nuse\tO\nto\tO\n,\tO\nbecause\tO\nit\tO\nis\tO\nsmaller\tO\nthan\tO\nthe\tO\nlaptop\tO\n.\tO\n\nI\tO\nregret\tO\nbuying\tO\nit\tO\nbefore\tO\nunderstanding\tO\nhow\tO\nawful\tO\nit\tO\nis\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nThe\tO\nright\tB-aspectTerm\nspeaker\tI-aspectTerm\ndid\tO\nnot\tO\nwork\tO\n.\tO\n\nDealing\tO\nwith\tO\nthe\tO\nsupport\tO\ndrone\tB-aspectTerm\non\tO\nthe\tO\nother\tO\nend\tO\nof\tO\nthe\tO\nchat\tO\nwas\tO\nsheer\tO\ntorture\tO\n.\tO\n\nThe\tO\nFinal\tB-aspectTerm\nCut\tI-aspectTerm\nPro\tI-aspectTerm\non\tO\nthis\tO\nlaptop\tO\nis\tO\nso\tO\nfast\tO\nand\tO\neasy\tO\n,\tO\nand\tO\nI\tO\ncan\tO\nuse\tO\nthis\tO\nto\tO\nseemlessly\tO\ntransfer\tO\nall\tO\nmy\tO\nwork\tO\nto\tO\nmy\tO\nhome\tO\ncomputer\tO\n,\tO\nwhich\tO\nis\tO\nalso\tO\na\tO\nmac\tO\n.\tO\n\nThe\tO\ncomputer\tO\nruns\tB-aspectTerm\nextremely\tO\nslowly\tO\n,\tO\nwhether\tO\nopening\tO\nWord\tO\nor\tO\nMy\tO\nComputer\tO\n.\tO\n\nBut\tO\nI\tO\nam\tO\nglad\tO\nto\tO\nhave\tO\ngotten\tO\nmine\tO\nright\tO\nbefore\tO\nthey\tO\nstopped\tO\nmaking\tO\nit\tO\n.\tO\n\nThe\tO\nMac\tB-aspectTerm\nSnow\tI-aspectTerm\nLeopard\tI-aspectTerm\nO\tI-aspectTerm\n/\tI-aspectTerm\nS\tI-aspectTerm\nis\tO\nextremely\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nalthough\tO\nvery\tO\ndifferent\tO\nthan\tO\nWin\tB-aspectTerm\nXP\tI-aspectTerm\n,\tO\nVisa\tB-aspectTerm\nor\tO\nWin7\tB-aspectTerm\n.\tO\n\nA\tO\ntip\tO\nfor\tO\npeople\tO\nlooking\tO\ninto\tO\nthis\tO\ncomputer\tO\n:\tO\nDO\tO\nNOT\tO\nBUY\tO\nIT\tO\nsave\tO\nup\tO\na\tO\nbit\tO\nmore\tO\nmoney\tO\nand\tO\nbuy\tO\na\tO\ncomputer\tO\nthat\tO\nwill\tO\nlast\tO\n.\tO\n\nI\tO\n've\tO\nalways\tO\nused\tO\nPC\tO\n's\tO\nfor\tO\nwork\tO\nhome\tO\nand\tO\nthis\tO\nis\tO\nmy\tO\nfirst\tO\nexperience\tO\nwith\tO\na\tO\nMac\tO\n.\tO\n\ni\tO\nasked\tO\nmany\tO\npeople\tO\n,\tO\nsearch\tO\non\tO\nthe\tO\nnet\tO\nand\tO\nalso\tO\nread\tO\nreviews\tO\nhere\tO\nin\tO\nbest\tO\nbuy\tO\n.\tO\n\nStartup\tB-aspectTerm\nin\tO\nabout\tO\n30\tO\nseconds\tO\n,\tO\nshutdown\tB-aspectTerm\nin\tO\n2\tO\n-\tO\n4\tO\nseconds\tO\n,\tO\nresume\tB-aspectTerm\nfrom\tI-aspectTerm\nsleep\tI-aspectTerm\nin\tO\n0\tO\n-\tO\n2\tO\nseconds\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nnice\tO\nand\tO\nthe\tO\nimages\tO\ncomes\tO\nvery\tO\nclear\tO\n,\tO\nthe\tO\nkeyboard\tB-aspectTerm\nand\tO\nthe\tO\nfit\tB-aspectTerm\njust\tO\nfeels\tO\nright\tO\n.\tO\n\nI\tO\nreturned\tO\nit\tO\nto\tO\nBest\tO\nBuy\tO\non\tO\nthe\tO\nninteenth\tO\nof\tO\nApril\tO\n.\tO\n\nI\tO\nhave\tO\nonly\tO\nhad\tO\nPCs\tO\nwith\tO\nWindows\tB-aspectTerm\nbefore\tO\nso\tO\nthis\tO\ntakes\tO\na\tO\nlittle\tO\ngetting\tO\nuse\tO\nto\tO\n.\tO\n\nI\tO\nwas\tO\nso\tO\nexcited\tO\nto\tO\nreceive\tO\nthe\tO\nToshiba\tO\nL455\tO\nas\tO\na\tO\ngift\tO\n/\tO\nbonus\tO\nfor\tO\nsome\tO\nwork\tO\nI\tO\nhad\tO\ndone\tO\nfor\tO\na\tO\nfriend\tO\nof\tO\nmine\tO\n!\tO\n\nI\tO\nhad\tO\nleft\tO\nmy\tO\nregular\tO\nlaptop\tO\nat\tO\nhome\tO\nand\tO\nneeded\tO\nsomething\tO\nto\tO\nuse\tO\nwhile\tO\nout\tO\nof\tO\ntown\tO\n.\tO\n\nSummary\tO\n:\tO\nAfter\tO\ndoing\tO\nsome\tO\ninvestigation\tO\non\tO\nthe\tO\nweb\tO\n,\tO\nI\tO\nhave\tO\nfound\tO\nthat\tO\nToshiba\tO\nNB205s\tO\nare\tO\nnot\tO\nchronically\tO\nnot\tO\nbooting\tO\n.\tO\n\nsuper\tO\nfast\tO\nprocessor\tB-aspectTerm\nand\tO\nreally\tO\nnice\tO\ngraphics\tB-aspectTerm\ncard\tI-aspectTerm\n..\tO\n\nBut\tO\nsitting\tO\non\tO\na\tO\nlap\tO\nor\tO\non\tO\na\tO\ndesk\tO\nin\tO\nfront\tO\nof\tO\nyou\tO\nit\tO\nlooks\tO\nmore\tO\nthan\tO\nbig\tO\nenough\tO\n(\tO\nthis\tO\ncould\tO\nbe\tO\nbecause\tO\nI\tO\nm\tO\nused\tO\nto\tO\nmy\tO\nLenovo\tO\n10\tO\ntablet\tO\nnow\tO\n)\tO\nplus\tO\nthis\tO\nis\tO\na\tO\ngreat\tO\nsize\tB-aspectTerm\nif\tO\nI\tO\nwant\tO\nto\tO\nunplug\tO\nthe\tO\nexternal\tB-aspectTerm\nkeyboard\tI-aspectTerm\n,\tO\nmouse\tB-aspectTerm\n,\tO\nand\tO\nmonitor\tB-aspectTerm\nto\tO\ntake\tO\nit\tO\nwith\tO\nme\tO\nwhen\tO\nI\tO\ntake\tO\nphotos\tO\nand\tO\nvideo\tO\n.\tO\n\nI\tO\nContacted\tO\nHP\tO\nabout\tO\nthis\tO\nsituation\tO\nand\tO\nwas\tO\ngiven\tO\nexcuses\tO\n,\tO\nwithout\tO\nresults\tO\n.\tO\n\nYou\tO\nknow\tO\nwhat\tO\n?\tO\nI\tO\nhappened\tO\nto\tO\nbuy\tO\na\tO\ndefective\tO\nblood\tO\npressure\tO\nmonitor\tO\na\tO\nweek\tO\nago\tO\nat\tO\nthe\tO\nBukit\tO\nBatok\tO\nPolyclinic\tO\nNHG\tO\nPharmacy\tO\na\tO\nweek\tO\nago\tO\n.\tO\n\nThe\tO\nonly\tO\nobjection\tO\nI\tO\nhave\tO\nis\tO\nthat\tO\nafter\tO\nyou\tO\nbuy\tO\nit\tO\nthe\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nsystem\tI-aspectTerm\nis\tO\na\tO\nstarter\tO\nand\tO\ncharges\tO\nfor\tO\nthe\tO\nupgrade\tO\n.\tO\n\nI\tO\ndislike\tO\nthe\tO\nweight\tB-aspectTerm\nand\tO\nsize\tB-aspectTerm\n,\tO\ncubersome\tO\n.\tO\n\nThe\tO\nwheel\tB-aspectTerm\nthat\tO\nturns\tO\nthe\tO\nvolume\tO\nup\tO\nand\tO\ndown\tO\ndoes\tO\nn't\tO\nwork\tO\nin\tO\nreal\tO\ntime\tO\n.\tO\n\nI\tO\nca\tO\nn't\tO\neven\tO\ninstall\tO\none\tO\nof\tO\nthe\tO\n3\tO\nprinters\tO\nI\tO\nhave\tO\nin\tO\nmy\tO\nhouse\tO\nso\tO\nI\tO\nam\tO\nunable\tO\nto\tO\nprint\tO\n.\tO\n\nI\tO\ncan\tO\nnot\tO\nbe\tO\nhappier\tO\nwith\tO\nthe\tO\nservice\tB-aspectTerm\nor\tO\nproduct\tO\n.\tO\n\nEverything\tO\nwas\tO\nso\tO\neasy\tO\n.\tO\n\nTo\tO\nlist\tO\na\tO\nfew\tO\n:\tO\nThey\tO\ntend\tO\nto\tO\nget\tO\nhot\tO\nenough\tO\nto\tO\ncause\tO\n3rd\tO\ndegree\tO\nburns\tO\n,\tO\nas\tO\nwell\tO\nas\tO\nignite\tO\nany\tO\nflamable\tO\nmaterial\tO\nif\tO\nnear\tO\nthe\tO\npart\tO\nthat\tO\nhappens\tO\nto\tO\nheat\tO\nup\tO\n.\tO\n\nGot\tO\nthis\tO\nfor\tO\na\tO\ngraduation\tO\ngift\tO\nfor\tO\nmy\tO\ndaughter\tO\nfor\tO\nher\tO\nto\tO\nuse\tO\nat\tO\ncollege\tO\n.\tO\n\nI\tO\ndo\tO\ntranscription\tO\nwork\tO\non\tO\nthe\tO\nside\tO\n,\tO\nand\tO\nthe\tO\nflatline\tB-aspectTerm\nkeyboard\tI-aspectTerm\nmakes\tO\ntyping\tO\nquick\tO\nand\tO\neasy\tO\nas\tO\nwell\tO\n.\tO\n\nAfter\tO\n5\tO\nmonths\tO\nof\tO\nfailed\tO\nrepairs\tO\n,\tO\nrequested\tO\na\tO\nfull\tO\nrefund\tO\nbut\tO\nwas\tO\nrefused\tO\nand\tO\nit\tO\nstill\tO\nis\tO\nnot\tO\nrepaired\tO\nand\tO\nAcer\tO\nis\tO\nindifferent\tO\nto\tO\nthe\tO\nissue\tO\n.\tO\n\nThe\tO\nToshiba\tO\nlaptop\tO\nwas\tO\na\tO\ngreat\tO\npurchase\tO\n.\tO\n\nAfter\tO\nyears\tO\nof\tO\nusing\tO\nPCs\tO\n,\tO\na\tO\nnew\tO\nMac\tO\nuser\tO\nis\tO\nbasically\tO\nforced\tO\nto\tO\nre\tO\n-\tO\nlearn\tO\nhow\tO\nto\tO\nuse\tO\na\tO\ncomputer\tO\n.\tO\n\nSpeakers\tB-aspectTerm\ndoes\tO\nn't\tO\nsound\tO\nthat\tO\ngreat\tO\n.\tO\n\nYou\tO\nbetter\tO\nbelieve\tO\nmy\tO\nnext\tO\ncomputer\tO\nwill\tO\nbe\tO\na\tO\nMAC\tO\n!\tO\n\nI\tO\nlove\tO\nit\tO\n!\tO\n\nI\tO\nlove\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nbut\tO\ni\tO\nca\tO\nn't\tO\ngive\tO\nToshiba\tO\nany\tO\ncredit\tO\nfor\tO\nthat\tO\n,\tO\nunless\tO\ny'\tO\nall\tO\nget\tO\nserious\tO\nabout\tO\nergonomics\tB-aspectTerm\nand\tO\nmaking\tO\nrequired\tO\nconnections\tB-aspectTerm\nless\tO\nobtrusive\tO\ni\tO\nwill\tO\nbe\tO\nlooking\tO\nto\tO\ndifferent\tO\nmanufacturer\tO\nnext\tO\ntime\tO\n.\tO\n\nNow\tO\nthat\tO\nI\tO\nhave\tO\nit\tO\nI\tO\nsee\tO\nthat\tO\nI\tO\nreally\tO\nneeded\tO\nthis\tO\nfor\tO\nmuch\tO\nmore\tO\n.\tO\n\nAfter\tO\nnumerous\tO\ncalls\tO\nto\tO\nApplecare\tB-aspectTerm\ntech\tI-aspectTerm\nsupport\tI-aspectTerm\n,\tO\nI\tO\nwas\tO\ndirected\tO\nto\tO\nsend\tO\nin\tO\nmy\tO\ncomputer\tO\n;\tO\n\nThe\tO\n\"\tO\nabuse\tO\n\"\tO\nis\tO\nthat\tO\nI\tO\npushed\tO\nthe\tO\npower\tB-aspectTerm\nplug\tI-aspectTerm\nin\tO\ntoo\tO\nhard\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\nfind\tO\ndocuments\tO\n,\tO\nand\tO\nkeep\tO\nthem\tO\nin\tO\none\tO\narea\tO\n.\tO\n\nThe\tO\nresolution\tB-aspectTerm\non\tI-aspectTerm\nthe\tI-aspectTerm\nscreen\tI-aspectTerm\nis\tO\nalmost\tO\npure\tO\nHD\tO\n.\tO\n\nWith\tO\nall\tO\nthe\tO\nprograms\tB-aspectTerm\nthat\tO\ncame\tO\nwith\tO\nit\tO\n,\tO\nsuch\tO\nas\tO\niLife\tB-aspectTerm\nand\tO\niWork\tB-aspectTerm\n,\tO\nI\tO\nwas\tO\nset\tO\nfrom\tO\nthe\tO\nvery\tO\nbeginning\tO\n.\tO\n\nNot\tO\nsure\tO\nhow\tO\nI\tO\nrecommend\tO\nit\tO\nfor\tO\nquality\tO\ngaming\tB-aspectTerm\n,\tO\nas\tO\nI\tO\nhave\tO\na\tO\ndesktop\tO\nrig\tO\nfor\tO\nthat\tO\nreason\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nnetbook\tO\nfor\tO\ntraveling\tO\n,\tO\nand\tO\nit\tO\n's\tO\ngreat\tO\n-\tO\nlight\tO\n,\tO\nfunctional\tO\n,\tO\nand\tO\nmeets\tO\nmy\tO\nneeds\tO\n.\tO\n\nEasy\tO\nlearning\tO\ncurve\tO\n.\tO\n\nI\tO\ngo\tO\nto\tO\npurchase\tO\nit\tO\non\tO\nline\tO\n,\tO\nand\tO\nI\tO\nfind\tO\nout\tO\nthat\tO\nthe\tO\ndevice\tO\nwill\tO\nnot\tO\nbe\tO\navailable\tO\nuntil\tO\nalmost\tO\ntwo\tO\nmonths\tO\nlater\tO\n!\tO\n\ndell\tO\nis\tO\na\tO\ndecently\tO\nmade\tO\npc\tO\n.\tO\n\nGreat\tO\nvalue\tB-aspectTerm\n,\tO\nfast\tO\ndelivery-\tB-aspectTerm\nComputer\tO\nworks\tO\nas\tO\nif\tO\nbrand\tO\nnew\tO\n,\tO\nno\tO\nproblems\tO\n,\tO\nvery\tO\npleased\tO\n\nThe\tO\nInternet\tB-aspectTerm\nExplorer\tI-aspectTerm\nwas\tO\nvery\tO\nslow\tO\nfrom\tO\nthe\tO\nvery\tO\nbeginning\tO\n.\tO\n\nThe\tO\nAC\tB-aspectTerm\npower\tI-aspectTerm\nport\tI-aspectTerm\nbecomes\tO\nloose\tO\nover\tO\ntime\tO\n\nBest\tO\nBuy\tO\nlaughed\tO\nwhen\tO\nI\tO\ntold\tO\nthem\tO\nthey\tO\nshould\tO\nreplace\tO\nit\tO\ninstead\tO\nof\tO\nexpecting\tO\nme\tO\nto\tO\nbe\tO\nwithout\tO\na\tO\ncomputer\tO\nagain\tO\nfor\tO\nanother\tO\ncouple\tO\nof\tO\nweeks\tO\n.\tO\n\nAs\tO\na\tO\nuser\tO\nof\tO\na\tO\nPC\tO\n,\tO\nI\tO\nwill\tO\nwill\tO\nadmit\tO\nthat\tO\nthe\tO\nmacBook\tO\nPro\tO\nhas\tO\na\tO\nbetter\tO\nrunning\tB-aspectTerm\nsystem\tI-aspectTerm\nin\tO\nwhich\tO\nI\tO\nfound\tO\nmyself\tO\n\"\tO\nGetting\tO\nthe\tO\njob\tO\ndone\tO\nquicker\tO\n.\tO\n\nThe\tO\ncomputer\tO\nwould\tO\nnot\tO\never\tO\ncut\tO\nback\tO\non\tO\n.\tO\n\nThe\tO\nease\tO\nin\tO\nwhich\tO\nyou\tO\nset\tO\neverything\tO\nup\tO\nis\tO\nsuch\tO\nthat\tO\na\tO\nchild\tO\ncould\tO\ndo\tO\nit\tO\n.\tO\n\ni\tO\nwould\tO\nhave\tO\nto\tO\nsay\tO\nthat\tO\noverall\tO\nits\tO\ngreat\tO\n!\tO\n\nThere\tO\nare\tO\nno\tO\ngold\tO\nkey\tO\nnumbers\tO\ntoo\tO\nintall\tO\nprograms\tB-aspectTerm\n,\tO\nyou\tO\nmust\tO\nuse\tO\nthe\tO\nserial\tO\nnumbers\tO\nthat\tO\nit\tO\ndoes\tO\nnot\tO\naccept\tO\nand\tO\nthen\tO\nthings\tO\nare\tO\nlimited\tO\nas\tO\nfar\tO\na\tO\nworking\tO\nbecause\tO\nthey\tO\nare\tO\nonly\tO\ngood\tO\nfor\tO\na\tO\nshort\tO\ntime\tO\n.\tO\n\nand\tO\nthey\tO\nreplaced\tO\nthe\tO\nawesome\tO\nergonomic\tO\nsmall\tO\nlightweight\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nwith\tO\na\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nthat\tO\nweighed\tO\nmore\tO\nthan\tO\nthe\tO\nmachine\tO\nitself\tO\n.\tO\n\nIt\tO\n's\tO\nthe\tO\ninside\tO\nthat\tO\nis\tO\ntruly\tO\nwonderful\tO\n.\tO\n\nEnjoy\tO\nthat\tO\nToshib\tO\nforce\tB-aspectTerm\nand\tO\ndurability\tB-aspectTerm\nunparalleled\tO\n\nI\tO\npurchased\tO\nthis\tO\nlaptop\tO\n9\tO\nmonths\tO\nago\tO\n!\tO\n\nWhich\tO\nis\tO\ngreat\tO\nI\tO\nam\tO\nrunning\tO\nVista\tB-aspectTerm\nBusiness\tI-aspectTerm\nand\tO\nscored\tO\na\tO\n5.X\tO\non\tO\nthe\tO\nindex\tO\nI\tO\nhave\tO\nnever\tO\nseen\tO\na\tO\nwindows\tO\nmachine\tO\nhave\tO\na\tO\ntotal\tO\nscore\tO\nin\tO\nthe\tO\n5\tO\n's\tO\n.\tO\n\nReturning\tO\nthis\tO\nas\tO\nsoon\tO\nas\tO\nI\tO\nget\tO\nout\tO\nof\tO\nwork\tO\n\nI\tO\nuse\tO\nthe\tO\ncomputer\tO\nto\tO\nbasically\tO\ncheck\tO\nemails\tO\n,\tO\nsurf\tB-aspectTerm\nthe\tI-aspectTerm\nweb\tI-aspectTerm\n,\tO\nprint\tO\ncoupons\tO\nand\tO\nfor\tO\nmy\tO\ncollege\tO\npapers\tO\n.\tO\n\nThis\tO\nunit\tO\nis\tO\nnot\tO\n.\tO\n\nWe\tO\nlove\tO\nthe\tO\nsize\tB-aspectTerm\nof\tI-aspectTerm\nthe\tI-aspectTerm\nscreen\tI-aspectTerm\n,\tO\nalthough\tO\nit\tO\nis\tO\nstill\tO\nlightweight\tO\nand\tO\nvery\tO\neasy\tO\nto\tO\ntote\tB-aspectTerm\naround\tO\n.\tO\n\nThey\tO\nare\tO\nn't\tO\nworth\tO\nthe\tO\nmoney\tO\n,\tO\neven\tO\nthough\tO\nthey\tO\nare\tO\non\tO\nthe\tO\ncheap\tO\nside\tO\n,\tO\nlaptop\tO\nspeaking\tO\n.\tO\n\nEither\tO\nway\tO\nthe\tO\nentire\tO\nthing\tO\nwas\tO\njust\tO\na\tO\njoke\tO\n,\tO\na\tO\ncomplete\tO\nrip\tO\noff\tO\n!\tO\n\nso\tO\nthe\tO\nfact\tO\nthat\tO\nthe\tO\ncomputer\tO\ndoes\tO\nnot\tO\nwork\tB-aspectTerm\non\tO\nthe\tO\n24\tO\ntwenty\tO\nfourth\tO\nday\tO\nis\tO\nmy\tO\nfault\tO\n.\tO\n\nSo\tO\nglad\tO\nI\tO\ndecided\tO\nto\tO\nupgrade\tO\n!\tO\n\nI\tO\nwould\tO\ndefinitely\tO\nreccomend\tO\nthis\tO\nif\tO\nyou\tO\nare\tO\nin\tO\nthe\tO\nmarket\tO\nfor\tO\nan\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nstylish\tO\n,\tO\nfun\tO\n,\tO\nawesome\tO\ncomputer\tO\n.\tO\n\nthe\tO\nbattery\tO\nis\tB-aspectTerm\nirreplaceable\tO\n.\tO\n\n*\tO\nIF\tO\nYOU\tO\nARE\tO\nLOOKING\tO\nFOR\tO\nA\tO\nGOOD\tO\nLAPTOP\tO\n,\tO\nTHIS\tO\nIS\tO\nNOT\tO\nIT\tO\n!\tO\n\nIf\tO\nyou\tO\nwant\tO\na\tO\nlittle\tO\nmore\tO\ncustom\tO\nability\tO\n,\tO\ndrop\tO\na\tO\nfew\tO\nbucks\tO\nand\tO\nupgrade\tO\nto\tO\none\tO\nof\tO\nthe\tO\nmore\tO\nrobust\tO\nversions\tO\nof\tO\nWin\tB-aspectTerm\n7\tI-aspectTerm\nand\tO\ngrab\tO\na\tO\n2\tB-aspectTerm\nGB\tI-aspectTerm\nstick\tI-aspectTerm\nof\tI-aspectTerm\nmemory\tI-aspectTerm\nto\tO\nspice\tO\nit\tO\nall\tO\nup\tO\na\tO\nbit\tO\nmore\tO\n.\tO\n\nIt\tO\n's\tO\ncatatonic\tO\n.\tO\n\nI\tO\nhave\tO\nnever\tO\nreally\tO\nbeen\tO\nbig\tO\non\tO\ndownloading\tO\nanything\tO\nso\tO\nI\tO\nwas\tO\nn't\tO\ntoo\tO\nworried\tO\nabout\tO\ngetting\tO\na\tO\nvirus\tO\n,\tO\nplus\tO\nI\tO\nthought\tO\nI\tO\nwas\tO\nprotected\tO\nby\tO\nNorton\tB-aspectTerm\n.\tO\n\nThe\tO\ninternet\tB-aspectTerm\nwas\tO\nlocekd\tO\nand\tO\nfroze\tO\nevery\tO\ntime\tO\nit\tO\nwas\tO\ntrying\tO\nto\tO\nbe\tO\nused\tO\n,\tO\nand\tO\nthe\tO\ncommand\tB-aspectTerm\nprompt\tI-aspectTerm\nwould\tO\nnot\tO\nwork\tO\nat\tO\nall\tO\n.\tO\n\nIt\tO\n's\tO\nsoftware\tB-aspectTerm\nand\tO\nspeed\tB-aspectTerm\nenable\tO\nit\tO\nto\tO\ndo\tO\namazing\tO\nthings\tO\n.\tO\n\nThe\tO\nToshiba\tO\nSatellite\tO\nlaptop\tO\nis\tO\nDESIGNED\tO\nto\tO\nfail\tO\n!\tO\n\nHe\tO\ncame\tO\ninto\tO\nmy\tO\nhouse\tO\n,\tO\nfiddled\tO\naround\tO\non\tO\nthe\tO\ncomputer\tO\nfor\tO\na\tO\ngood\tO\nforty\tO\nminutes\tO\nand\tO\ngot\tO\nready\tO\nto\tO\nleave\tO\nbefore\tO\nit\tO\nwas\tO\neven\tO\ndone\tO\ndoing\tO\nwhat\tO\nhe\tO\nwas\tO\ndoing\tO\nto\tO\nit\tO\n.\tO\n\nMy\tO\nwireless\tO\nprovider\tO\nconfirmed\tO\nmy\tO\nhome\tO\ninternet\tO\nis\tO\nfine\tO\n,\tO\nand\tO\nany\tO\nconnections\tO\nI\tO\nturn\tO\non\tO\nshould\tO\nwork\tO\n.\tO\n\nCould\tO\nnot\tO\nkeep\tO\nup\tO\nwith\tO\nme\tO\nand\tO\nfinally\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nwent\tO\nout\tO\n.\tO\n\nI\tO\ncould\tO\nhave\tO\npurchased\tO\na\tO\ncheap\tO\ncomputer\tO\nto\tO\ndo\tO\nwhat\tO\nI\tO\n'm\tO\ndoing\tO\nnow\tO\n!\tO\n\nI\tO\nam\tO\nmost\tO\nimpressed\tO\nwith\tO\nthe\tO\nprogramming\tB-aspectTerm\n,\tO\nincluding\tO\nthe\tO\niPhoto\tB-aspectTerm\n.\tO\n\nSpeakers\tB-aspectTerm\ntoo\tO\nsmall\tO\nto\tO\nbe\tO\nof\tO\nany\tO\nreal\tO\nuse\tO\n.\tO\n\nI\tO\nupgraded\tO\nit\tO\n's\tO\nRAM\tB-aspectTerm\nto\tO\n2\tO\nGB\tO\n,\tO\nI\tO\nam\tO\nvery\tO\nhappy\tO\nwith\tO\nit\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\ngreat\tO\ncomputer\tO\n.\tO\n\nI\tO\npurchased\tO\na\tO\nToshiba\tO\nSatellite\tO\nM60\tO\n(\tO\nwith\tO\nharman\tO\n/\tO\nkardon\tO\nspeakers\tB-aspectTerm\n!\tO\n)\tO\nin\tO\nDecember\tO\nof\tO\n2005\tO\n.\tO\n\nDismantle\tO\nthe\tO\nwhole\tO\nthing\tO\n?\tO\nThen\tO\nit\tO\nwill\tO\nnot\tO\nbe\tO\na\tO\nnewly\tO\nmanufactured\tO\nset\tO\nlike\tO\nbefore\tO\n.\tO\n\nThey\tO\nshould\tO\nhave\tO\nincluded\tO\nmore\tO\nmemory\tB-aspectTerm\non\tO\ntheir\tO\ncomputers\tO\nif\tO\nthey\tO\nknew\tO\nVista\tB-aspectTerm\nwould\tO\nrun\tO\nslowly\tO\n.\tO\n\nBattery\tB-aspectTerm\nlife\tI-aspectTerm\ncould\tO\nbe\tO\nbetter\tO\nbut\tO\noverall\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\nand\tO\nToshiba\tO\n's\tO\nreputation\tO\nfor\tO\nlaptops\tO\nit\tO\n's\tO\ngreat\tO\n!\tO\n\nThe\tO\nbattery\tB-aspectTerm\nnever\tO\nheld\tO\na\tO\ncharge\tB-aspectTerm\nlonger\tO\nthan\tO\none\tO\nhour\tO\nand\tO\nwithin\tO\ntwo\tO\nmonths\tO\n,\tO\nstopped\tO\nholding\tO\na\tO\ncharge\tB-aspectTerm\nfor\tO\nmore\tO\nthan\tO\nten\tO\nminutes\tO\n.\tO\n\nIt\tO\nwould\tO\nn't\tO\nfit\tO\nin\tO\nmost\tO\n17-inch\tO\nbags\tO\n.\tO\n\nThe\tO\nfirst\tO\ntime\tO\nit\tO\ncrashed\tO\nwas\tO\nmaybe\tO\ngoing\tO\non\tO\na\tO\nyear\tO\nand\tO\na\tO\nhalf\tO\nof\tO\nhaving\tO\nit\tO\n.\tO\n\nAfter\tO\nthe\tO\nwarrenty\tO\nexpired\tB-aspectTerm\nthe\tO\nhard\tO\ndrive\tB-aspectTerm\nwent\tI-aspectTerm\nbad\tO\nand\tO\nit\tO\nwould\tO\nhave\tO\ncost\tO\nmore\tO\nto\tO\nfix\tO\nthen\tO\nto\tO\nreplace\tO\n.\tO\n\nI\tO\npaid\tO\n$\tO\n800\tO\nfor\tO\nthis\tO\ncomputer\tO\nfrom\tO\nmy\tO\nschool\tO\ncampus\tO\nbookstore\tO\n.\tO\n\nIt\tO\nis\tO\nsmall\tO\nenough\tO\nto\tO\nfit\tO\nin\tO\none\tO\nof\tO\nmy\tO\npurses\tO\n!\tO\n\nThe\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nStarter\tI-aspectTerm\nis\tO\n,\tO\nin\tO\nmy\tO\nopinion\tO\n,\tO\na\tO\ngreat\tO\nway\tO\nto\tO\nthink\tO\nabout\tO\nusing\tO\nyour\tO\nnetbook\tO\n:\tO\nbasics\tO\n,\tO\nbasics\tO\n,\tO\nbasics\tO\n.\tO\n\nI\tO\nwas\tO\nvery\tO\nworried\tO\nabout\tO\nmaking\tO\nthe\tO\ntwo\tO\ncompatible-\tO\nbut\tO\nliterally\tO\n,\tO\nit\tO\nwas\tO\nso\tO\nsimple\tO\nI\tO\nwas\tO\nalmost\tO\nworried\tO\nthat\tO\nI\tO\nwas\tO\ndoing\tO\nsomething\tO\nwrong\tO\n.\tO\n\nNote\tO\nthat\tO\nI\tO\ndo\tO\nn't\tO\nordinarily\tO\ntake\tO\nthe\tO\ntime\tO\nto\tO\nwrite\tO\na\tO\nreview\tO\n.\tO\n\nThe\tO\nneat\tO\nand\tO\norganized\tO\nicon\tB-aspectTerm\nlist\tI-aspectTerm\nis\tO\na\tO\nwelcome\tO\nchange\tO\nfrom\tO\ncluttered\tO\nand\tO\nconfusing\tO\ndesktop\tB-aspectTerm\nicons\tI-aspectTerm\n.\tO\n\nI\tO\npurchased\tO\nthis\tO\nnetbook\tO\nafter\tO\nmy\tO\noriginal\tO\nToshiba\tO\nlaptop\tO\ncrashed\tO\nright\tO\nafter\tO\nthe\tO\nwarranty\tB-aspectTerm\nexpired\tO\n.\tO\n\nApparently\tO\nwell\tO\n-\tO\nbuilt\tB-aspectTerm\nand\tO\ngorgeous\tO\nto\tO\nlook\tB-aspectTerm\nat\tO\n,\tO\nthe\tO\ni5\tO\nMacBook\tO\nPro\tO\nis\tO\na\tO\nwinning\tO\ncombination\tO\nof\tO\nprice\tB-aspectTerm\nand\tO\nperformance\tB-aspectTerm\n.\tO\n\nASUS\tO\nhas\tO\ndone\tO\nan\tO\noutstanding\tO\njob\tO\nof\tO\nevolving\tO\ntheir\tO\nnetbooks\tO\n,\tO\nand\tO\nI\tO\nwould\tO\nrecommend\tO\nthis\tO\nto\tO\nanyone\tO\nwho\tO\nboth\tO\nunderstands\tO\ntheir\tO\nneeds\tO\nand\tO\nhow\tO\nnetbooks\tO\ncan\tO\nfit\tO\nthem\tO\n.\tO\n\nThe\tO\napple\tB-aspectTerm\ncare\tI-aspectTerm\nhas\tO\nnever\tO\nfailed\tO\nme\tO\n,\tO\nand\tO\nI\tO\nexpect\tO\nit\tO\nto\tO\nbe\tO\nthe\tO\nsame\tO\nfor\tO\nthis\tO\ncomputer\tO\nas\tO\nwell\tO\n.\tO\n\nBuyer\tO\nBeware\tO\n.\tO\n\nIt\tO\nhas\tO\nserved\tO\nmy\tO\nneeds\tO\nquite\tO\nnicely\tO\nfor\tO\nthe\tO\nmost\tO\npart\tO\n.\tO\n\nThe\tO\nToshiba\tO\nlaptop\tO\nI\tO\nam\tO\nusing\tO\nis\tO\neasier\tO\nto\tO\nuse\tB-aspectTerm\nthan\tO\nmost\tO\nI\tO\nhave\tO\ntried\tO\n.\tO\n\nSo\tO\nI\tO\ncalled\tO\nCompaq\tO\n,\tO\nand\tO\nafter\tO\nbeing\tO\non\tO\nthe\tO\nphone\tO\nfor\tO\n3\tO\nhours\tO\n,\tO\ni\tO\nfinally\tO\ngot\tO\na\tO\nreplacement\tO\nwhich\tO\nI\tO\nshould\tO\nn't\tO\nhave\tO\nhad\tO\na\tO\nproblem\tO\ngetting\tO\nsince\tO\nit\tO\nwas\tO\nunder\tO\nwarranty\tB-aspectTerm\n.\tO\n\nSo\tO\nwe\tO\nexchanged\tO\nit\tO\nfor\tO\nthe\tO\nsame\tO\non\tO\nand\tO\nafter\tO\n2\tO\nhours\tO\nit\tO\ndid\tO\nn't\tO\nwork\tB-aspectTerm\n.\tO\n\ndo\tO\nnot\tO\nbuy\tO\nyou\tO\nwill\tO\nbe\tO\ndisappointed\tO\n.\tO\n\nI\tO\njust\tO\nrecently\tO\nhad\tO\nto\tO\nship\tO\nmy\tO\nlaptop\tO\nback\tO\nto\tO\nHP\tO\nfor\tO\nrepair\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nto\tO\ntake\tO\nit\tO\nto\tO\nthe\tO\ngeek\tO\nsquad\tO\nguys\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\nbecause\tO\nit\tO\nhas\tO\nhad\tO\nviruses\tO\n3\tO\ntimes\tO\nand\tO\ni\tO\nhave\tO\nnot\tO\neven\tO\nhad\tO\nit\tO\nfor\tO\nmore\tO\nthen\tO\n4\tO\nmonths\tO\n!\tO\n\nWe\tO\ndo\tO\nn't\tO\nMind\tO\nand\tO\nYou\tO\ndo\tO\nn't\tO\nMatter\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nsize\tB-aspectTerm\n,\tO\nkeyboard\tB-aspectTerm\n,\tO\nthe\tO\nfunctions\tB-aspectTerm\n.\tO\n\nBut\tO\nas\tO\ntime\tO\nwent\tO\non\tO\nI\tO\nfound\tO\nit\tO\nalmost\tO\nimpossible\tO\nto\tO\nkeep\tO\nthe\tO\nthing\tO\non\tO\n-\tO\nline\tO\nthrough\tO\nwi\tO\n-\tO\nfi\tO\n.\tO\n\nthe\tO\nmouse\tB-aspectTerm\nis\tO\nway\tO\nway\tO\nway\tO\nto\tO\nsensitve\tO\n.\tO\n\nToshiba\tO\nknows\tO\nthere\tO\nis\tO\na\tO\nmanufacturing\tO\ndefect\tO\nbut\tO\nwill\tO\nnot\tO\nacknowledge\tO\nit\tO\n.\tO\n\nThe\tO\nOS\tB-aspectTerm\nis\tO\nstill\tO\nas\tO\nfast\tO\nas\tO\nthe\tO\nday\tO\nthat\tO\nthe\tO\nlaptop\tO\nwas\tO\npurchased\tO\nand\tO\ncontinues\tO\nto\tO\nrun\tB-aspectTerm\nflawlessly\tO\n.\tO\n\nAlso\tO\n,\tO\nI\tO\nissued\tO\na\tO\nreplacement\tO\nRMA\tO\nfor\tO\na\tO\nfew\tO\ndead\tO\npixels\tO\nin\tO\nthe\tO\nupper\tO\nzone\tO\nof\tO\nthe\tO\nscreen\tB-aspectTerm\n,\tO\nwhich\tO\nis\tO\nnoticable\tO\nto\tO\nme\tO\n.\tO\n\nWaited\tO\non\tO\ngetting\tO\nthis\tO\ncomputer\tO\n,\tO\nbut\tO\nit\tO\nhas\tO\nbeen\tO\na\tO\ngreat\tO\nchange\tO\n.\tO\n\nAfter\tO\nway\tO\ntoo\tO\nmany\tO\ntimes\tO\nsending\tO\nthe\tO\nthing\tO\nin\tO\nfor\tO\nrepairs\tO\n(\tO\ndelivery\tB-aspectTerm\nservice\tI-aspectTerm\nwas\tO\nslow\tO\n,\tO\nand\tO\nwithout\tO\nthe\tO\nlaptop\tO\nI\tO\nhad\tO\nno\tO\naccess\tO\nto\tO\nthe\tO\ninternet\tO\n,\tO\nand\tO\nthus\tO\nno\tO\nway\tO\nof\tO\ntracking\tO\nit\tO\nto\tO\nfind\tO\nout\tO\nwhen\tO\nI\tO\nmight\tO\nhope\tO\nto\tO\nsee\tO\nmy\tO\ncomputer\tO\nagain\tO\n)\tO\n,\tO\nit\tO\nfinally\tO\nkicked\tO\nthe\tO\nbucket\tO\nafter\tO\njust\tO\nover\tO\n2\tO\nyears\tO\n.\tO\n\nMy\tO\nfriend\tO\nreports\tO\nthe\tO\nnotebook\tO\nis\tO\nastonishing\tO\nin\tO\nperformance\tB-aspectTerm\n,\tO\npicture\tB-aspectTerm\nquality\tI-aspectTerm\n,\tO\nand\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\n.\tO\n\nthe\tO\ni3\tB-aspectTerm\nprocessor\tI-aspectTerm\ndoes\tO\nn't\tO\nseem\tO\nto\tO\nrun\tO\nhot\tO\nand\tO\nthe\tO\nfan\tB-aspectTerm\nrarely\tO\nturns\tO\non\tO\n.\tO\n\nI\tO\nwas\tO\ngetting\tO\nextrememly\tO\nfrustrated\tO\nwhen\tO\nI\tO\nwould\tO\nwant\tO\nto\tO\ndo\tO\nthese\tO\nsimple\tO\ntaks\tO\nthat\tO\nI\tO\nwould\tO\nhave\tO\nto\tO\nwait\tO\nand\tO\nwait\tO\nand\tO\nwait\tO\nfor\tO\nthings\tO\nto\tO\ndownload\tO\nor\tO\nvirus\tO\nthat\tO\nwould\tO\nclog\tO\nup\tO\nmy\tO\nPC\tO\n.\tO\n\nEnjoy\tO\nyour\tO\nsitdown\tO\n\nThe\tO\nbattery\tO\nnever\tB-aspectTerm\nheld\tO\na\tO\ncharge\tO\nlonger\tB-aspectTerm\nthan\tO\none\tO\nhour\tO\nand\tO\nwithin\tO\ntwo\tO\nmonths\tO\n,\tO\nstopped\tO\nholding\tO\na\tO\ncharge\tO\nfor\tB-aspectTerm\nmore\tO\nthan\tO\nten\tO\nminutes\tO\n.\tO\n\nAnother\tO\nTHREE\tO\nweeks\tO\nlater\tO\nI\tO\nhad\tO\nmy\tO\nlaptop\tO\nback\tO\nwith\tO\na\tO\nnew\tO\nmousepad\tO\n,\tB-aspectTerm\nkeys\tO\n,\tB-aspectTerm\nand\tO\ncasing\tO\n.\tB-aspectTerm\n\nI\tO\nhave\tO\nhad\tO\nmy\tO\nnew\tO\nMacbook\tO\nPro\tO\ni5\tO\nfor\tO\na\tO\ncouple\tO\nof\tO\ndays\tO\nand\tO\nhave\tO\nrecycled\tO\nALL\tO\nof\tO\nmy\tO\nold\tO\nPC\tO\nlaptops\tO\n.\tO\n\nSee\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\nlaptops\tO\nyou\tO\nbuy\tO\nit\tO\nand\tO\nget\tO\njust\tO\na\tO\nnormal\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nwith\tO\ntrials\tO\nof\tO\nmust\tO\nneed\tO\nstuff\tO\nthat\tO\nshould\tO\ncome\tO\nwith\tO\nit\tO\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\ndo\tO\nn't\tO\nunderstand\tO\nis\tO\nthat\tO\nthe\tO\nresolution\tB-aspectTerm\nof\tI-aspectTerm\nthe\tI-aspectTerm\nscreen\tI-aspectTerm\nis\tO\nn't\tO\nhigh\tO\nenough\tO\nfor\tO\nsome\tO\npages\tO\n,\tO\nsuch\tO\nas\tO\nYahoo!Mail\tO\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\nI\tO\nwish\tO\nthis\tO\nhad\tO\nwas\tO\nthe\tO\noption\tO\nto\tO\nturn\tO\noff\tO\nthe\tO\ntouchpad\tB-aspectTerm\nwith\tO\na\tO\nbutton\tO\nlike\tO\nmy\tO\nbig\tO\n16\tO\n\"\tO\nlaptop\tO\ndoes\tO\n.\tO\n\nvery\tO\nconvenient\tO\nwhen\tO\nyou\tO\ntravel\tO\nand\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nexcellent\tO\n...\tO\n\nThe\tO\nmachine\tO\nis\tO\nslow\tO\nto\tO\nboot\tO\nup\tB-aspectTerm\nand\tI-aspectTerm\noccasionally\tO\ncrashes\tO\ncompletely\tO\n.\tO\n\nThis\tO\nis\tO\ngreat\tO\nif\tO\nyou\tO\nhave\tO\nseveral\tO\nlectures\tO\nback\tO\nto\tO\nback\tO\nand\tO\ndo\tO\nn't\tO\nhave\tO\na\tO\nchance\tO\nto\tO\ncharge\tB-aspectTerm\nduring\tO\none\tO\nof\tO\nthe\tO\nlectures\tO\n.\tO\n\nI\tO\nwish\tO\nToshiba\tO\nwould\tO\nallow\tO\ntheir\tO\ncustomers\tO\nto\tO\nselect\tO\nan\tO\noption\tO\nthat\tO\nonly\tO\nboots\tO\nthe\tO\nOS\tB-aspectTerm\nat\tO\nsetup\tO\nand\tO\nremoves\tO\nall\tO\nthe\tO\nunnecessary\tO\nstuff\tO\n.\tO\n\nAt\tO\nfirst\tO\nit\tO\n's\tO\nlike\tO\nyou\tO\n're\tO\nin\tO\nthat\tO\nhoneymoon\tO\nstage\tO\nwith\tO\nyour\tO\nlaptop\tO\n.\tO\n\nI\tO\ndid\tO\nn't\tO\nwant\tO\nto\tO\nbuy\tO\na\tO\ngeneric\tO\nbrand\tO\ncomputer\tO\nbut\tO\nit\tO\nis\tO\nreally\tO\nnice\tO\n.\tO\n\ni\tO\ncan\tO\nuse\tO\nit\tO\nfor\tO\nall\tO\nof\tO\nmy\tO\nneeds\tO\n.\tO\n\nAfter\tO\ndoing\tO\nCAD\tO\nwork\tO\nall\tO\nday\tO\nat\tO\nwork\tO\n,\tO\nusing\tO\na\tO\nhigher\tO\nend\tO\nPC\tO\n,\tO\nI\tO\ncould\tO\nn't\tO\ncome\tO\nhome\tO\nand\tO\nsettle\tO\nfor\tO\nthe\tO\nuse\tO\nof\tO\na\tO\nlower\tO\nend\tO\ncomputer\tO\n.\tO\n\nthe\tO\nscreen\tB-aspectTerm\nbrightness\tI-aspectTerm\nautomatically\tO\nadjusts\tO\n.\tO\n\nI\tO\nespecially\tO\nlike\tO\nthe\tO\nbacklit\tB-aspectTerm\nkeyboard\tI-aspectTerm\n.\tO\n\nEither\tO\nway\tO\nI\tO\n'm\tO\nfurious\tO\n.\tO\n\nBesides\tO\nthe\tO\ngreat\tO\nlook\tB-aspectTerm\n,\tO\nit\tO\nis\tO\na\tO\ngreat\tO\nmachine\tO\n.\tO\n\nMy\tO\nlaptop\tO\ncost\tB-aspectTerm\napproximately\tO\n$\tO\n2,300\tO\nand\tO\nDIED\tO\nafter\tO\nonly\tO\n2-years\tO\n,\tO\n10-months\tO\nand\tO\n18-days\tO\nof\tO\nuse\tO\n.\tO\n\nThe\tO\nsound\tB-aspectTerm\nis\tO\na\tO\nbit\tO\nquiet\tO\nif\tO\nyou\tO\n're\tO\non\tO\na\tO\nplane\tO\n,\tO\nthis\tO\ncan\tO\neasily\tO\nbe\tO\novercome\tO\nwith\tO\na\tO\ndecent\tO\npair\tO\nof\tO\nhead\tO\nphones\tO\n.\tO\n\nI\tO\nwas\tO\nnot\tO\naware\tO\nthat\tO\nthis\tO\nproduct\tO\ncan\tO\nnot\tO\ndisplay\tO\nwebsites\tO\nthat\tO\ncontain\tO\nFlash\tO\n.\tO\n\nThis\tO\ncomputer\tO\nwas\tO\nbought\tO\nbecause\tO\nI\tO\nwanted\tO\n\"\tO\ntop\tO\nof\tO\nthe\tO\nline\tO\n\"\tO\n,\tO\nfast\tO\n,\tO\nreliable\tO\n,\tO\nHA\tO\n.\tO\n\nA\tO\nlot\tO\nof\tO\nhelp\tO\nthey\tO\nWEREN'T\tO\n!\tO\n\n(\tO\nThe\tO\nSATA\tB-aspectTerm\ncontroller\tI-aspectTerm\nis\tO\nthe\tO\nmotherboard\tB-aspectTerm\nchip\tI-aspectTerm\nthat\tO\nlets\tO\nthe\tO\nCPU\tB-aspectTerm\ntalk\tO\nto\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n)\tO\n\nI\tO\nwill\tO\nnever\tO\nbuy\tO\nanything\tO\nfrom\tO\nHP\tO\nagain\tO\n!\tO\n\nI\tO\nca\tO\nn't\tO\nimagine\tO\nEVER\tO\nbuying\tO\na\tO\nPC\tO\nagain\tO\n!\tO\n\nThe\tO\nbuttons\tB-aspectTerm\nyou\tO\nhave\tO\nto\tO\npress\tO\na\tO\nlittle\tO\nharder\tO\nthan\tO\nmost\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwas\tO\nsupposed\tO\nto\tO\nbe\tO\n6\tO\nhours\tO\n,\tO\nbut\tO\neven\tO\nif\tO\nI\tO\nran\tO\noff\tO\nthe\tO\nbattery\tB-aspectTerm\nwith\tO\nthe\tO\nhigh\tO\neffeciency\tO\nsetting\tO\nthe\tO\nbattery\tB-aspectTerm\nwould\tO\nonly\tO\nlast\tO\nme\tO\non\tO\naverage\tO\nabout\tO\n2.5\tO\nto\tO\n3\tO\nhours\tO\n.\tO\n\nIt\tO\nallows\tO\nyou\tO\nto\tO\nautomatically\tO\nupload\tO\nphotos\tO\nto\tO\nyour\tO\nFacebook\tO\naccount\tO\nwith\tO\none\tO\nclick\tO\n.\tO\n\nTook\tO\nit\tO\nback\tO\nas\tO\nit\tO\nwas\tO\ndefective\tO\n.\tO\n\nOther\tO\nThoughts\tO\n:\tO\nI\tO\nlove\tO\nnewegg\tO\n,\tO\nI\tO\nrecommend\tO\nthem\tO\nto\tO\nthe\tO\nworld\tO\nhowever\tO\nthis\tO\nis\tO\njust\tO\nunacceptable\tO\n.\tO\n\nNow\tO\n17\tO\nmonths\tO\nlater\tO\nthey\tO\nwant\tO\n(\tO\nwould\tO\nnot\tO\nsay\tO\nexact\tO\namount\tO\n)\tO\n$\tO\n165.00\tO\nto\tO\n$\tO\n400\tO\nto\tO\nfix\tO\nthe\tO\nmachine\tO\n.\tO\n\nI\tO\nsimply\tO\ngot\tO\ntired\tO\nof\tO\na\tO\nbad\tO\ncomputer\tO\nlike\tO\nwindows\tO\nwith\tO\nits\tO\nconstant\tO\nfreezing\tO\nand\tO\nanti\tO\n-\tO\nvirus\tO\n.\tO\n\nI\tO\nam\tO\nnot\tO\none\tO\nto\tO\nthrow\tO\nthings\tO\nlike\tO\nthis\tO\naround\tO\nbut\tO\nit\tO\nis\tO\na\tO\nlaptop\tO\nso\tO\ncarrying\tO\nit\tO\naround\tO\ndoes\tO\nseem\tO\nto\tO\nmean\tO\nit\tO\nwill\tO\nbe\tO\njerked\tO\npossibly\tO\na\tO\nlittle\tO\n,\tO\nwhile\tO\ndriving\tO\na\tO\ncar\tO\nand\tO\ncarrying\tO\nit\tO\ninto\tO\nwhere\tO\never\tO\nyou\tO\nare\tO\nusing\tO\nit\tO\n.\tO\n\nRight\tO\nsize\tB-aspectTerm\nand\tO\nweight\tB-aspectTerm\nfor\tO\nportability\tB-aspectTerm\n.\tO\n\nWe\tO\ndecided\tO\nwe\tO\nwould\tO\ntry\tO\nto\tO\ntrade\tO\n-\tO\nin\tO\nour\tO\nold\tO\nones\tO\n.\tO\n\nSo\tO\nfar\tO\n,\tO\nso\tO\ngood\tO\n!\tO\n\nIt\tO\ntook\tO\na\tO\nlittle\tO\nover\tO\n2\tO\nweeks\tO\nuntil\tO\ni\tO\ngot\tO\nit\tO\nback\tO\n.\tO\n\nEventually\tO\nthe\tO\nscreen\tO\nwent\tO\nblank\tO\nand\tO\nthe\tO\ncomputer\tO\nwould\tO\nnot\tO\nturn\tO\non\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nalso\tO\ndoes\tO\nn't\tO\nkeep\tO\nup\tO\nwith\tO\nthe\tO\nclaim\tO\nbut\tO\nstill\tO\nI\tO\nthink\tO\nmacbook\tO\nis\tO\nmuch\tO\nahead\tO\nfrom\tO\nthe\tO\nrest\tO\nof\tO\nthe\tO\npack\tO\n.\tO\n\nIt\tO\nwas\tO\nloaded\tO\nwith\tO\nWindows\tO\nVista\tB-aspectTerm\nHome\tI-aspectTerm\nPremium\tI-aspectTerm\n--\tI-aspectTerm\ndelivered\tO\nwith\tO\nonly\tO\n1\tO\nGB\tO\nof\tB-aspectTerm\nRAM\tI-aspectTerm\n,\tI-aspectTerm\nand\tO\nit\tO\nwas\tO\na\tO\n*\tO\ndog*.\tO\n\nWhat\tO\na\tO\nwaste\tO\nof\tO\ntime\tO\nit\tO\nwas\tO\nto\tO\nrun\tO\na\tO\nDefrag\tO\non\tO\nthe\tO\nPC\tO\n!\tO\n\nThe\tO\nreflectiveness\tO\nof\tO\nthe\tO\ndisplay\tB-aspectTerm\nis\tO\nonly\tO\na\tO\nminor\tO\ninconvenience\tO\nif\tO\nyou\tO\nwork\tO\nin\tO\na\tO\ncontrolled\tO\n-\tO\nlighting\tO\nenvironment\tO\nlike\tO\nme\tO\n(\tO\nI\tO\nprefer\tO\nit\tO\ndark\tO\n)\tO\nor\tO\nif\tO\nyou\tO\ncan\tO\ncrank\tO\nup\tO\nthe\tO\nbrightness\tB-aspectTerm\n.\tO\n\nMy\tO\none\tO\ncomplaint\tO\nwith\tO\nthis\tO\nlaptop\tO\nis\tO\nthat\tO\nI\tO\n've\tO\nnoticed\tO\nan\tO\nelectronic\tB-aspectTerm\nfuzz\tI-aspectTerm\nsound\tI-aspectTerm\ncoming\tO\nout\tO\nof\tO\nthe\tO\nheadphone\tB-aspectTerm\njack\tI-aspectTerm\nwhen\tO\nheadphones\tO\nare\tO\nplugged\tO\nin\tO\n.\tO\n\nThis\tO\nsystem\tO\nis\tO\nnot\tO\nworth\tO\nthe\tO\nmoney\tO\nor\tO\ntrouble\tO\ntrying\tO\nto\tO\nget\tO\nit\tO\nfix\tO\n.\tO\n\nUPDATE\tO\n:\tO\nTwo\tO\nyears\tO\nafter\tO\nbuying\tO\nthis\tO\nlaptop\tO\n,\tO\nI\tO\nam\tO\nnow\tO\nthe\tO\nproud\tO\nowner\tO\nof\tO\na\tO\nlemon\tO\n.\tO\n\nWhile\tO\nit\tO\nwas\tO\nhighly\tO\nrated\tO\n,\tO\nwould\tO\nI\tO\nlike\tO\nit\tO\n?\tO\nI\tO\ntried\tO\nthe\tO\nkeyboard\tB-aspectTerm\nat\tO\nthe\tO\nstore\tO\n,\tO\nand\tO\nit\tO\nseemed\tO\nok\tO\n.\tO\n\nTreat\tO\nyourself\tO\nto\tO\na\tO\nmore\tO\nexpensive\tO\n,\tO\nlong\tO\n-\tO\nlasting\tO\nlaptop\tO\nof\tO\nquality\tB-aspectTerm\nlike\tO\na\tO\nSony\tO\n,\tO\nApple\tO\n,\tO\nor\tO\nToshiba\tO\n.\tO\n\nI\tO\nlove\tO\nit\tO\n-\tO\nnever\tO\nhad\tO\na\tO\ncomputer\tO\nI\tO\nwas\tO\nso\tO\nimpressed\tO\nwith\tO\n-\tO\nand\tO\nI\tO\n've\tO\nhad\tO\na\tO\nlot\tO\nof\tO\nlaptops\tO\nand\tO\ndesktops\tO\n-\tO\nthis\tO\none\tO\nis\tO\nFAR\tO\nAND\tO\nABOVE\tO\nTHE\tO\nBEST\tO\nONE\tO\nI\tO\nEVER\tO\nHAD\tO\nBEFORE\tO\n.\tO\n\nWe\tO\ndid\tO\nnot\tO\neven\tO\nhave\tO\nit\tO\na\tO\nyear\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nto\tO\ncall\tO\nwith\tO\na\tO\nfew\tO\nquestions\tO\nor\tO\nissues\tO\nand\tO\nthey\tO\nhave\tO\nhelped\tO\nme\tO\nfor\tO\nfree\tO\n,\tO\neven\tO\nwithout\tO\nthe\tO\nwarranty\tB-aspectTerm\n.\tO\n\nSo\tO\nyou\tO\nout\tO\nof\tO\nof\tO\nnotebook\tO\nand\tO\nmoney\tO\n.\tO\n\nWas\tO\nsearching\tO\nonline\tO\nfor\tO\na\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nwhen\tO\nI\tO\nfound\tO\nthis\tO\nsite\tO\n.\tO\n\nBut\tO\nto\tO\nbe\tO\nhonest\tO\n,\tO\nI\tO\ndo\tO\nn't\tO\nuse\tO\nmy\tO\ncomputer\tO\nfor\tO\nanything\tO\nlike\tO\ngraphics\tB-aspectTerm\nediting\tI-aspectTerm\nand\tO\ncomplex\tB-aspectTerm\ndata\tI-aspectTerm\nanalysis\tI-aspectTerm\nand\tO\ngaming\tB-aspectTerm\n.\tO\n\nI\tO\nwould\tO\nrather\tO\nspend\tO\nmy\tO\nmoney\tO\non\tO\na\tO\ncomputer\tO\nthat\tO\ncosts\tO\nmore\tB-aspectTerm\nthen\tO\na\tO\nToshiba\tO\nthat\tO\nis\tO\nn't\tO\ngood\tO\nat\tO\nall\tO\n.\tO\n\n(\tO\nNo\tO\nproblem\tO\nwith\tO\nthe\tO\nordering\tO\nor\tO\nshipping\tB-aspectTerm\nby\tO\nthe\tO\nway\tO\n.\tO\n\nAnd\tO\nthe\tO\nram\tB-aspectTerm\n(\tO\nthe\tO\nthing\tO\nthat\tO\nmakes\tO\nit\tO\nfaster\tO\n)\tO\ncomes\tO\nsporting\tO\n2\tO\ngigs\tO\nfor\tO\nhigh\tO\nperformance\tB-aspectTerm\nto\tO\nhandle\tO\nmore\tO\nstuff\tO\nat\tO\nonce\tO\nand\tO\nsurf\tB-aspectTerm\nthe\tI-aspectTerm\nweb\tI-aspectTerm\na\tO\nwhole\tO\nlot\tO\nfaster\tO\nthan\tO\nbefore\tO\n.\tO\n\nThe\tO\none\tO\nthing\tO\nI\tO\nwish\tO\nit\tO\nhad\tO\nwas\tO\na\tO\ndetailed\tO\nhardcopy\tB-aspectTerm\nmanuel\tI-aspectTerm\n.\tO\n\nI\tO\nedit\tO\nand\tO\nburn\tO\nto\tO\nDVD\tO\na\tO\nlot\tO\nof\tO\nvideo\tO\n,\tO\nso\tO\nI\tO\nobviously\tO\ncould\tO\nnot\tO\nlive\tO\nwith\tO\na\tO\nnon\tO\n-\tO\nfunctioning\tO\ndrive\tB-aspectTerm\n.\tO\n\nFast\tO\n,\tO\ngreat\tO\nvisual\tB-aspectTerm\n!\tO\n\nIt\tO\n's\tO\npriced\tB-aspectTerm\nvery\tO\nreasonable\tO\nand\tO\nworks\tB-aspectTerm\nvery\tO\nwell\tO\nright\tO\nout\tO\nof\tO\nthe\tO\nbox\tO\n.\tO\n\nYou\tO\nwill\tO\nneed\tO\nthem\tO\nif\tO\nyou\tO\nwant\tO\nto\tO\nreload\tO\nthe\tO\nOS\tB-aspectTerm\n(\tO\nI\tO\nrecommend\tO\ndoing\tO\nif\tO\nyou\tO\ncan\tO\nto\tO\nstart\tO\nfresh\tO\nand\tO\noptimal\tO\n)\tO\n.\tO\n\napple\tO\nand\tO\nquess\tO\nwhat\tO\n,\tO\nyou\tO\nhave\tO\nto\tO\nsend\tO\nthe\tO\nwhole\tO\nlaptop\tO\nin\tO\n,\tO\ntoo\tO\nbad\tO\n,\tO\nso\tO\nsad\tO\n\nIf\tO\nyou\tO\ncould\tO\nstretch\tO\nby\tO\na\tO\nfew\tO\n100\tO\ndollars\tO\nI\tO\nhighly\tO\nrecommend\tO\nyou\tO\nshould\tO\nreplace\tO\nyour\tO\nWindows\tO\nlaptop\tO\nwith\tO\nthis\tO\none\tO\n.\tO\n\nmight\tO\nhave\tO\nto\tO\nbuy\tO\none\tO\nfor\tO\nme\tO\nnow\tO\n,\tO\nsince\tO\nI\tO\nuse\tO\nit\tO\nall\tO\nthe\tO\ntime\tO\n.\tO\n\nwhile\tO\nthe\tO\nkeyboard\tB-aspectTerm\nitself\tO\nis\tO\nalright\tO\n,\tO\nthe\tO\nplate\tB-aspectTerm\naround\tO\nit\tO\nis\tO\ncheap\tO\nplastic\tO\nand\tO\nmakes\tO\na\tO\nhollow\tO\nsound\tO\nwhen\tO\nusing\tO\nthe\tO\nmouse\tB-aspectTerm\ncommand\tI-aspectTerm\nbuttons\tI-aspectTerm\n.\tO\n\nI\tO\npurchased\tO\nit\tO\nthis\tO\nyear\tO\nwhen\tO\nmy\tO\nold\tO\nHP\tO\nlaptop\tO\nfinally\tO\ndied\tO\nand\tO\nI\tO\nwas\tO\nlooking\tO\nfor\tO\nsomething\tO\nsmaller\tO\nand\tO\nlighter\tO\nthan\tO\na\tO\nlaptop\tO\nto\tO\ncarry\tO\naround\tO\nfor\tO\nclasses\tO\nand\tO\ntraveling\tO\n.\tO\n\nI\tO\nHave\tO\na\tO\nfriend\tO\nwho\tO\nhas\tO\nthe\tO\nother\tO\nmodel\tO\nand\tO\nwe\tO\nput\tO\nthem\tO\nside\tO\nby\tO\nside\tO\nwith\tO\nthe\tO\nsame\tO\ndvd\tO\nin\tO\n(\tO\nbattle\tO\nof\tO\nthe\tO\nSmithsonian\tO\n)\tO\nAfter\tO\non\tO\nHour\tO\nmine\tO\nwas\tO\nat\tO\n53\tO\n%\tO\nlife\tO\nleft\tO\nand\tO\nhis\tO\nwas\tO\nat\tO\n69\tO\n%\tO\nlife\tO\nleft\tO\n.\tO\n\nThe\tO\nlatest\tO\nis\tO\non\tO\nmy\tO\nLG\tO\nNetbook\tO\nX12\tO\n\nPurchased\tO\nas\tO\na\tO\ngift\tO\nfor\tO\na\tO\nfriend\tO\n.\tO\n\nI\tO\nwould\tO\nnot\tO\nrecommend\tO\nthe\tO\npurchase\tO\nof\tO\nthis\tO\nmodle\tO\nof\tO\nToshiba\tO\nComputer\tO\nor\tO\nany\tO\nToshiba\tO\nproduct\tO\nfor\tO\nthat\tO\nmatter\tO\n.\tO\n\nI\tO\n've\tO\nnever\tO\nhad\tO\nproblems\tO\nwith\tO\nviruses\tO\n.\tO\n\nAfter\tO\nthey\tO\nfound\tO\nno\tO\nother\tO\nway\tO\n,\tO\nthey\tO\ntold\tO\nme\tO\nto\tO\ncourier\tO\nit\tO\nto\tO\nthem(since\tO\nthey\tO\ndo\tO\nn't\tO\nallow\tO\nthe\tO\nuse\tO\nof\tO\nthe\tO\npost\tO\noffice\tO\n)\tO\nat\tO\nmy\tO\nexpense\tO\n,\tO\nand\tO\nsent\tO\nme\tO\na\tO\n4\tO\npage\tO\nlist\tO\nof\tO\nvery\tO\nspecific\tO\npackaging\tO\ninstructions\tO\nto\tO\nfollow\tO\nor\tO\nit\tO\nwould\tO\nn't\tO\nbe\tO\ncovered\tO\n.\tO\n\nThere\tO\nare\tO\nso\tO\nmany\tO\nwonderful\tO\nfeatures\tB-aspectTerm\nand\tO\nbenefits\tO\nto\tO\nthe\tO\nnew\tO\nMacBook\tO\n!\tO\n\nthe\tO\nmcbook\tO\npro\tO\nnotebook\tO\nwill\tO\nmake\tO\nit\tO\neasy\tO\nfor\tO\nyou\tO\nto\tO\nwrite\tO\nand\tO\nread\tO\nyour\tO\nemails\tO\nat\tO\nblazing\tO\nspeeds\tB-aspectTerm\n.\tO\n\nThe\tO\nonly\tO\nthing\tO\ni\tO\ncan\tO\nsay\tO\nis\tO\nthat\tO\nthe\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\ndoes\tO\nnt\tO\nwork\tO\nlike\tO\nit\tO\nshould\tO\nall\tO\nthe\tO\ntime\tO\n.\tO\n\nHowever\tO\n,\tO\nI\tO\nlove\tO\nthis\tO\nparticular\tO\nMac\tO\nbecause\tO\nits\tO\nvery\tO\nfast\tO\n,\tO\ngreat\tO\nsize\tB-aspectTerm\n,\tO\nand\tO\nhas\tO\nfantastic\tO\nfeatures\tB-aspectTerm\nlike\tO\nthe\tO\nlighted\tB-aspectTerm\nkeyboard\tI-aspectTerm\nand\tO\neasy\tO\nmouse\tB-aspectTerm\npad\tI-aspectTerm\n.\tO\n\nBattery\tB-aspectTerm\nlife\tI-aspectTerm\nneeds\tO\nmore\tO\nlife\tO\n.\tO\n\nFor\tO\nsome\tO\nodd\tO\nreasons\tO\nthe\tO\ncomputer\tO\ndoes\tO\nn't\tO\nreconize\tO\nthe\tO\noperation\tB-aspectTerm\nsystem\tI-aspectTerm\n.\tO\n\nI\tO\nhad\tO\nto\tO\nwait\tO\n3\tO\nweeks\tO\nto\tO\nget\tO\nit\tO\nback\tO\nand\tO\nit\tO\nstill\tO\nis\tO\nnot\tO\nworking\tO\nproperly\tO\n.\tO\n\nI\tO\nam\tO\ngoing\tO\nto\tO\ngo\tO\nback\tO\nand\tO\nreturn\tO\nat\tO\nStore\tO\nI\tO\nbought\tO\nfrom\tO\n!\tO\n\nThe\tO\ntrackpad\tB-aspectTerm\nwas\tO\neasy\tO\nto\tO\nlearn\tO\nand\tO\nnavigate\tO\n.\tO\n\nApplications\tB-aspectTerm\nopen\tO\nin\tO\nseconds\tO\nand\tO\nthere\tO\nare\tO\nno\tO\nlags\tO\n,\tO\nhiccups\tO\nor\tO\nawkward\tO\nmoments\tO\nwhen\tO\nyou\tO\nwonder\tO\nwhether\tO\nyour\tO\ncomputer\tO\nis\tO\nout\tO\nfor\tO\ntea\tO\n.\tO\n\nMy\tO\nhusband\tO\npurchased\tO\na\tO\nlaptop\tO\nat\tO\nthe\tO\nsame\tO\ntime\tO\nfor\tO\nabout\tO\n$\tO\n300\tO\nless\tO\n(\tO\nhe\tO\ngot\tO\na\tO\npc\tO\n)\tO\n.\tO\n\nI\tO\nrespond\tO\nthat\tO\nI\tO\ndo\tO\nnot\tO\nhave\tO\nthe\tO\nold\tO\ncomputer\tO\nand\tO\nthis\tO\nway\tO\nI\tO\nwould\tO\nlose\tO\nthe\tO\ndata\tO\non\tO\nmy\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nAgain\tO\nin\tO\nFebruary\tO\nmy\tO\ncomputer\tO\ncompletely\tO\nfailed\tO\nto\tO\nthe\tO\npoint\tO\nthat\tO\nit\tO\ncould\tO\nnot\tO\nload\tO\nWindows\tB-aspectTerm\nso\tO\nI\tO\ncontacted\tO\nAcer\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\nthru\tO\nmy\tO\nWarrenty\tB-aspectTerm\nand\tO\nit\tO\ntook\tO\nabout\tO\n3\tO\ndays\tO\nfighting\tO\non\tO\nthe\tO\nphone\tO\nwith\tO\nagents\tB-aspectTerm\nand\tO\nit\tO\nseemed\tO\nas\tO\nthough\tO\nNONE\tO\nof\tO\nthem\tO\nspoke\tO\nEnglish\tO\n.\tO\n\nI\tO\nthink\tO\nthis\tO\nps\tO\nwas\tO\nmanufactured\tO\nin\tO\nthe\tO\nmid\tO\n90\tO\n's\tO\n.\tO\n\nboth\tO\nupgrades\tO\nwere\tO\nquickly\tO\naccomplished\tO\nafter\tO\npurchasing\tO\nthe\tO\nnecessary\tO\nProduct\tO\nKey\tO\n.\tO\n\nI\tO\nhave\tO\nowned\tO\nit\tO\nonly\tO\ntwo\tO\nmonths\tO\n!\tO\n\nI\tO\nlove\tO\nmy\tO\nmacbook\tO\npro\tO\n!\tO\n\nFrom\tO\nthe\tO\nmoment\tO\nI\tO\nopened\tO\nthe\tO\nbox\tO\nto\tO\nthe\tO\npresent\tO\nit\tO\nhas\tO\nbeen\tO\na\tO\ngreat\tO\njoy\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\neMachines\tO\nNotebook\tO\nPC\tO\nin\tO\nJanuary\tO\nof\tO\nthis\tO\nyear\tO\nand\tO\nI\tO\nam\tO\nhighly\tO\ndissatisfied\tO\nwith\tO\nit\tO\n.\tO\n\nEven\tO\nthough\tO\nthe\tO\ncomputer\tO\nis\tO\nlarger\tO\nthey\tO\ndid\tO\nnot\tO\nmake\tO\nthe\tO\nkeyboard\tB-aspectTerm\nlarger\tO\n.\tO\n\nThanks\tO\n,\tO\nMacConnection\tO\n,\tO\nfor\tO\nmaking\tO\nthis\tO\na\tO\nseamless\tO\npurchase\tO\n!\tO\n\nWe\tO\npaid\tO\nfor\tO\nthe\tO\nthree\tB-aspectTerm\nyear\tI-aspectTerm\nwarranty\tI-aspectTerm\nand\tO\nthe\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\nafter\tO\nthat\tO\none\tO\nended\tO\nas\tO\nwell\tO\n.\tO\n\nIts\tO\nnot\tO\njust\tO\nslow\tO\non\tO\nthe\tO\ninternet\tB-aspectTerm\n,\tO\nits\tO\nslow\tO\nin\tO\ngeneral\tO\n.\tO\n\nIt\tO\nhas\tO\njust\tO\nenough\tO\nRAM\tB-aspectTerm\nto\tO\nrun\tO\nsmoothly\tO\nand\tO\nenough\tO\nmemory\tB-aspectTerm\nto\tO\nsatisfy\tO\nmy\tO\nneeds\tO\n.\tO\n\nThe\tO\ndifference\tO\nis\tO\nphenomenal\tO\n.\tO\n\nI\tO\nacually\tO\nbelieve\tO\nthe\tO\nissue\tO\nis\tO\nwith\tO\nthe\tO\nNvidia\tB-aspectTerm\ngrafics\tI-aspectTerm\ncard\tI-aspectTerm\n,\tO\nbut\tO\nstill\tO\nrequires\tO\na\tO\nreturn\tO\n.\tO\n\nI\tO\nam\tO\na\tO\nfreelance\tO\ngraphic\tO\nartist\tO\n.\tO\n\nNo\tO\nwaiting\tO\nto\tO\nhave\tO\nmy\tO\nclaim\tO\nreviewed\tO\nby\tO\nsomeone\tO\nin\tO\nanother\tO\nstate\tO\n(\tO\nor\tO\nmore\tO\noften\tO\n,\tO\nanother\tO\ncountry\tO\n)\tO\n.\tO\n\nI\tO\ndid\tO\nnot\tO\nlike\tO\nmy\tO\nacer\tO\n.\tO\n\nMy\tO\nhusband\tO\ngot\tO\nme\tO\nthis\tO\nfor\tO\nChrismas\tO\nafter\tO\ngetting\tO\nme\tO\na\tO\nvery\tO\nexpensve\tO\nlaptop\tO\nthat\tO\ndid\tO\nnot\tO\nwork\tB-aspectTerm\nafter\tO\n2\tO\ndays\tO\n.\tO\n\nProblem\tO\nfixed\tO\nwhich\tO\nis\tO\ngreat\tO\nbut\tO\nthere\tO\nwent\tO\nanother\tO\ntwo\tO\nweeks\tO\nwithout\tO\nmy\tO\nlaptop\tO\nat\tO\nschool\tO\n.\tO\n\nThe\tO\nresolution\tB-aspectTerm\nis\tO\neven\tO\nhigher\tO\nthen\tO\nany\tO\nother\tO\nlaptop\tO\non\tO\nthe\tO\nmarket\tO\n.\tO\n\nThen\tO\njust\tO\nthe\tO\nother\tO\nday\tO\n,\tO\nmy\tO\nleft\tB-aspectTerm\n\"\tI-aspectTerm\nmouse\tI-aspectTerm\n\"\tI-aspectTerm\nbutton\tI-aspectTerm\nsnapped\tO\n!\tO\n\nIt\tO\nis\tO\nVERY\tO\neasy\tO\nto\tO\ntype\tB-aspectTerm\non\tO\nand\tO\nfeels\tO\ngreat\tO\n-\tO\nbesides\tO\nthe\tO\nadded\tO\nfeature\tB-aspectTerm\nthat\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\nlighted\tO\n.\tO\n\nLaptop\tO\nis\tO\nadvertised\tO\nas\tO\na\tO\n15\tB-aspectTerm\n\"\tI-aspectTerm\nbut\tO\nthe\tO\ncasing\tB-aspectTerm\nlooks\tO\nlike\tO\nthat\tO\nof\tO\na\tO\n17\tB-aspectTerm\n\"\tI-aspectTerm\n.\tO\n\nRemember\tO\nto\tO\ndo\tO\nyour\tO\nresearch\tO\nfirst\tO\nbefore\tO\nconsider\tO\nbuying\tO\na\tO\ntoshiba\tO\nproduct\tO\n.\tO\n\nI\tO\nbought\tO\nthis\tO\nlaptop\tO\nthe\tO\nmoment\tO\nunibody\tO\nproduct\tO\ncame\tO\nto\tO\nthe\tO\nmarket\tO\n.\tO\n\nThe\tO\nonly\tO\ntime\tO\nI\tO\nhave\tO\nrestarted\tO\nis\tO\nduring\tO\nsystem\tO\nupdates\tO\n.\tO\n\nmac\tO\nis\tO\nextremely\tO\ndifferent\tO\nthan\tO\nany\tO\nother\tO\nlaptop\tO\n.\tO\n\nThe\tO\nfeel\tB-aspectTerm\nof\tO\nthis\tO\nmachine\tO\ncompared\tO\nto\tO\nthe\tO\nold\tO\nMacBook\tO\nis\tO\nfar\tO\nsuperior\tO\n.\tO\n\nIn\tO\ndue\tO\ncourse\tO\n,\tO\nI\tO\n'll\tO\nremove\tO\nthe\tO\nhard\tB-aspectTerm\ndisc\tI-aspectTerm\nfrom\tO\nthis\tO\nnew\tO\nMacBook\tO\nPro\tO\nand\tO\ndump\tO\nit\tO\nwhere\tO\nit\tO\nbelongs\tO\n-\tO\nin\tO\nthe\tO\ntrash\tO\n.\tO\n\nIt\tO\n's\tO\ngreat\tO\nand\tO\nwe\tO\nwill\tO\nalways\tO\nstick\tO\nwith\tO\nApple\tO\ncomputers\tO\n,\tO\nwe\tO\nhave\tO\nbeen\tO\nso\tO\nhappy\tO\nwith\tO\nthem\tO\n.\tO\n\nI\tO\nshould\tO\nhave\tO\nrealized\tO\nthat\tO\ntrouble\tO\nwas\tO\nbrewing\tO\n.\tO\n\nThey\tO\nbreak\tO\ndown\tO\njust\tO\nas\tO\noften\tO\nas\tO\nPCs\tO\ndo\tO\n,\tO\nand\tO\nthe\tO\nonly\tO\nreason\tO\nthey\tO\ndo\tO\nn't\tO\nget\tO\nviruses\tO\n,\tO\nis\tO\nbecause\tO\nno\tO\none\tO\nmakes\tO\nviruses\tO\nfor\tO\nthem\tO\n,\tO\nthey\tO\n're\tO\nnot\tO\nbetter\tO\nin\tO\nany\tO\nway\tO\n,\tO\nthey\tO\nare\tO\nworse\tO\n,\tO\ntry\tO\nfinding\tO\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\nprograms\tI-aspectTerm\nfor\tI-aspectTerm\na\tI-aspectTerm\nMac\tI-aspectTerm\n,\tO\nthey\tO\ndo\tO\nn't\tO\nexist\tO\n.\tO\n\nThank\tO\nyou\tO\n.\tO\n\nThe\tO\nbenefits\tO\nwere\tO\nimmediate\tO\n!\tO\n\nMuch\tO\nfaster\tO\nthan\tO\nmy\tO\nold\tO\nwindows\tO\nlaptop\tO\nthat\tO\ndied\tO\non\tO\nme\tO\n.\tO\n\nNever\tO\nany\tO\ndoubt\tO\nI\tO\nwould\tO\nget\tO\na\tO\nMacBook\tO\n,\tO\njust\tO\nwas\tO\nn't\tO\nsure\tO\nwhich\tO\none\tO\n.\tO\n\nBut\tO\nwith\tO\nA\tO\nWAY\tO\nBigger\tO\nScreen\tB-aspectTerm\n,\tO\nand\tO\nIS\tO\nable\tO\nto\tO\nconnect\tO\nto\tO\nan\tO\nHDMI\tB-aspectTerm\n.\tO\n\nthe\tO\ngraphics\tB-aspectTerm\nare\tO\nawful\tO\nand\tO\nthe\tO\nwireless\tB-aspectTerm\nswitch\tI-aspectTerm\nit\tO\nat\tO\nthe\tO\ntop\tO\nrather\tO\nthan\tO\nthe\tO\nside\tO\nwhich\tO\nI\tO\nam\tO\nused\tO\nto\tO\nit\tO\nbeing\tO\non\tO\nthe\tO\nside\tO\n.\tO\n\nThe\tO\noverall\tO\nbuild\tB-aspectTerm\nquality\tI-aspectTerm\nof\tO\nthe\tO\nunit\tO\nis\tO\nexcellent\tO\nand\tO\nshe\tO\n'd\tO\nrecommend\tO\nit\tO\nto\tO\nanyone\tO\nelse\tO\nlooking\tO\nfor\tO\na\tO\nnetbook\tO\n.\tO\n\nI\tO\nbought\tO\nmy\tO\nAcer\tO\nAspire\tO\ncustom\tO\nmade\tO\nin\tO\nJune\tO\n2008\tO\n.\tO\n\nI\tO\nguess\tO\nhe\tO\nwas\tO\nthe\tO\ntechnical\tB-aspectTerm\nperson\tI-aspectTerm\n.\tO\n\nThey\tO\nclick\tO\n.\tO\n\nA\tO\nseventy\tO\ndollar\tO\nmouse\tB-aspectTerm\n!\tO\n\nThe\tO\nrepairs\tO\nwere\tO\nmade\tO\nquickly\tO\nthough\tO\nI\tO\nmust\tO\nsay\tO\n,\tO\nhowever\tO\nthe\tO\nsecond\tO\ntime\tO\nthey\tO\nshipped\tB-aspectTerm\nit\tO\nto\tO\nthe\tO\nincorrect\tO\naddress\tO\nand\tO\nit\tO\ntook\tO\nnearly\tO\na\tO\nweek\tO\nfor\tO\nthem\tO\nto\tO\nget\tO\nit\tO\nto\tO\nme\tO\n.\tO\n\nI\tO\nhave\tO\nthe\tO\nA65\tO\n-\tO\nright\tO\nnow\tO\nit\tO\n's\tO\na\tO\npaperweight\tO\n.\tO\n\nwhen\tO\ni\tO\nfirst\tO\ngot\tO\nit\tO\ni\tO\nthought\tO\nthe\tO\nsize\tB-aspectTerm\nof\tO\nit\tO\nwas\tO\na\tO\njoke\tO\n.\tO\n\nThat\tO\nbeing\tO\nsaid\tO\n,\tO\nit\tO\nstill\tO\nruns\tO\nvideo\tO\nin\tO\nfull\tO\nscreen\tO\ndecently\tO\n.\tO\n\nIt\tO\nis\tO\nfast\tO\nand\tO\ni\tO\nhave\tO\nnot\tO\nhad\tO\na\tO\nproblem\tO\nwith\tO\ninternet\tB-aspectTerm\nconnection\tI-aspectTerm\nor\tO\nany\tO\nother\tO\nproblems\tO\n.\tO\n\nI\tO\n'm\tO\nreally\tO\nimpressed\tO\nwith\tO\nthe\tO\nquality\tB-aspectTerm\nand\tO\nperformance\tB-aspectTerm\nfor\tO\nthe\tO\nprice\tB-aspectTerm\nof\tO\nthe\tO\ncomputer\tO\n.\tO\n\nBut\tO\nwhen\tO\nI\tO\nreceived\tO\nmy\tO\nreplacement\tO\n,\tO\nI\tO\nmade\tO\nBOTH\tO\nrecovery\tB-aspectTerm\nDVDs\tI-aspectTerm\n(\tO\n4\tO\n)\tO\n,\tO\nand\tO\na\tO\ndriver\tB-aspectTerm\n/\tI-aspectTerm\napplication\tI-aspectTerm\nDVD\tI-aspectTerm\n.\tO\n\nIn\tO\naddition\tO\n,\tO\nthere\tO\nis\tO\nphoto\tB-aspectTerm\ndetection\tI-aspectTerm\nsoftware\tI-aspectTerm\nthat\tO\nwill\tO\nallow\tO\nyou\tO\nto\tO\ngroup\tO\nall\tO\nthe\tO\nphotos\tO\ntogether\tO\nbased\tO\nupon\tO\nthe\tO\npeople\tO\nin\tO\nthe\tO\npicture\tO\n.\tO\n\nThe\tO\nspeakers\tB-aspectTerm\nare\tO\nterrible\tO\nand\tO\nare\tO\nprobably\tO\nthe\tO\ncheapest\tO\nones\tO\nI\tO\nhave\tO\never\tO\nseen\tO\nin\tO\na\tO\nlaptop\tO\nso\tO\nif\tO\nyour\tO\nplanning\tO\nto\tO\nlisten\tO\nto\tO\nmusic\tO\nI\tO\nsuggest\tO\nyou\tO\nget\tO\nsomething\tO\nbetter\tO\n.\tO\n\nSo\tO\nthen\tO\nyou\tO\nmay\tO\nbe\tO\nlucky\tO\nto\tO\nget\tO\nahold\tO\nto\tO\nsomeone\tO\nwho\tO\nunderstands\tO\nthat\tO\nits\tO\nno\tO\ngood\tO\nand\tO\nthey\tO\nwill\tO\nlet\tO\nyou\tO\nsend\tO\nit\tO\nback\tO\n,\tO\nbut\tO\nof\tO\ncourse\tO\nyou\tO\nare\tO\ntaking\tO\na\tO\nchance\tO\nof\tO\nthem\tO\ntesting\tO\nit\tO\nout\tO\nto\tO\nsee\tO\nwhat\tO\nhas\tO\nhappened\tO\n,\tO\nand\tO\nthey\tO\ntell\tO\nyou\tO\nthat\tO\nit\tO\nwas\tO\nnot\tO\non\tO\ntheir\tO\nside\tO\n,\tO\nthen\tO\nyou\tO\nare\tO\nstuck\tO\npaying\tO\nfor\tO\nthe\tO\nrepair\tO\n(\tO\nthe\tO\nprice\tB-aspectTerm\nof\tO\na\tO\nnew\tO\none\tO\n)\tO\n.\tO\n\nWhat\tO\n's\tO\nreally\tO\ngreat\tO\nabout\tO\nthis\tO\nproduct\tO\nis\tO\nyou\tO\nmay\tO\nhave\tO\na\tO\nfamily\tO\nmember\tO\nwho\tO\nis\tO\ncomputer\tO\nilliterate\tO\nand\tO\nyou\tO\ncan\tO\npretty\tO\nmuch\tO\njust\tO\nlet\tO\nthem\tO\nloose\tO\non\tO\nthis\tO\ncomputer\tO\nwithout\tO\nany\tO\nreal\tO\nsupervision\tO\n.\tO\n\nThe\tO\nlesson\tO\nlearned\tO\nhere\tO\nis\tO\n:\tO\nIt\tO\ndoes\tO\nnot\tO\npay\tO\nto\tO\nby\tO\nthis\tO\nloyal\tO\nto\tO\nany\tO\nbrand\tO\n,\tO\nsince\tO\nall\tO\nof\tO\nthem\tO\nare\tO\nthere\tO\nto\tO\nsimply\tO\nto\tO\nmake\tO\nas\tO\nmuch\tO\nmoney\tO\nas\tO\npossible\tO\n,\tO\nas\tO\nfast\tO\nas\tO\nthey\tO\ncan\tO\n,\tO\nand\tO\nin\tO\nthis\tO\nday\tO\nand\tO\nage\tO\n,\tO\nthe\tO\ncustomer\tO\nno\tO\nlonger\tO\nis\tO\nright\tO\nall\tO\nthe\tO\ntimes\tO\n.\tO\n\nPDF\tO\nfiles\tO\ncan\tO\nbe\tO\nviewed\tO\ninstantly\tO\n.\tO\n\nDell\tO\nLatitude\tO\nd620\tO\nis\tO\nnot\tO\na\tO\nreliable\tO\nmachine\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nit\tO\nfor\tO\nalmost\tO\nfour\tO\nyears\tO\nnow\tO\nand\tO\nI\tO\nhave\tO\nonly\tO\nhad\tO\na\tO\nfew\tO\nproblems\tO\nwith\tO\nit\tO\n.\tO\n\nOverall\tO\nfor\tO\nthe\tO\nmoney\tO\nthis\tO\nis\tO\na\tO\ngood\tO\ndeal\tO\n.\tO\n\nIt\tO\nis\tO\nso\tO\nsimple\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nI\tO\nuse\tO\nit\tO\nmore\tO\nthan\tO\nmy\tO\ndesktop\tO\n.\tO\n\nI\tO\nalso\tO\nhad\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\ntouchpad\tB-aspectTerm\nthat\tO\ncaused\tO\nthe\tO\nmouse\tB-aspectTerm\npointer\tI-aspectTerm\nto\tO\njump\tO\nall\tO\nover\tO\nthe\tO\nscreen\tB-aspectTerm\n.\tO\n\nI\tO\nsaved\tO\nfor\tO\nthis\tO\nlaptop\tO\nfor\tO\n3\tO\nmonths\tO\nand\tO\nI\tO\ncan\tO\ntell\tO\nyou\tO\npersonally\tO\nit\tO\nwas\tO\nworth\tO\nthe\tO\nwait\tO\n.\tO\n\nI\tO\nown\tO\na\tO\nHewlett\tO\nPackard\tO\nlaptop\tO\nand\tO\nI\tO\n've\tO\nhad\tO\nman\tO\nproblems\tO\nwith\tO\nit\tO\nsince\tO\nI\tO\nbought\tO\nin\tO\nin\tO\nFeb\tO\n,\tO\n201\tO\n\nIt\tO\nhas\tO\na\tO\noverheating\tO\nissue\tO\n-\tO\nnearly\tO\nto\tO\nthe\tO\npoint\tO\nof\tO\nbeing\tO\ndangerous\tO\n.\tO\n\nI\tO\nhave\tO\nhad\tO\nno\tO\nproblems\tO\nwith\tO\nit\tO\nunlike\tO\nsome\tO\nhardware\tB-aspectTerm\ndefects\tO\non\tO\npast\tO\nmodels\tO\n.\tO\n\nEITHER\tO\nWAY\tO\n,\tO\nTHE\tO\nKEYBOARD\tB-aspectTerm\nIS\tO\nUNSATISFACTORY\tO\n.\tO\n\nWell\tO\n,\tO\nI\tO\nhave\tO\nto\tO\nsay\tO\nsince\tO\nI\tO\nbought\tO\nmy\tO\nMac\tO\n,\tO\nI\tO\nwo\tO\nn't\tO\never\tO\ngo\tO\nback\tO\nto\tO\nany\tO\nWindows\tB-aspectTerm\n.\tO\n\nI\tO\ntook\tO\nit\tO\nin\tO\nto\tO\nthe\tO\nApple\tO\nstore\tO\nand\tO\nguess\tO\nwhat\tO\n?\tO\nThey\tO\nfixed\tO\nit\tO\n,\tO\nno\tO\ncost\tB-aspectTerm\nout\tO\nof\tO\npocket\tO\n.\tO\n\nI\tO\nhave\tO\nused\tO\ndifferent\tO\nlaptops\tO\nin\tO\nthe\tO\npast\tO\nand\tO\nI\tO\nhave\tO\nto\tO\nrate\tO\nthis\tO\none\tO\nway\tO\nabove\tO\nthe\tO\nrest\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nMac\tO\nso\tO\nmuch\tO\nbetter\tO\nthan\tO\nmy\tO\nwork\tO\nPC\tO\n!\tO\n\nThe\tO\nquality\tB-aspectTerm\n,\tO\nengineering\tB-aspectTerm\ndesign\tI-aspectTerm\nand\tO\nwarranty\tB-aspectTerm\nare\tO\nsuperior\tO\n--\tO\ncovers\tO\ndamage\tO\nfrom\tO\ndropping\tO\nthe\tO\nlaptop\tO\n.\tO\n\nI\tO\nrecommend\tO\nthe\tO\nMacbook\tO\nPro\tO\nif\tO\nyou\tO\nwant\tO\nthe\tO\nbest\tO\nlaptop\tO\non\tO\nthe\tO\nmarket\tO\n.\tO\n\nThe\tO\napplications\tB-aspectTerm\nare\tO\nalso\tO\nvery\tO\neasy\tO\nto\tO\nfind\tO\nand\tO\nmaneuver\tO\n,\tO\nmuch\tO\neasier\tO\nthan\tO\nany\tO\nother\tO\ncomputer\tO\nI\tO\nhave\tO\never\tO\nowned\tO\n.\tO\n\nThe\tO\nlarge\tO\nscreen\tB-aspectTerm\ngives\tO\nyou\tO\nthe\tO\noption\tO\nto\tO\ncomfortably\tO\nwatch\tO\nmovies\tO\nor\tO\nTV\tO\nshows\tO\non\tO\nyour\tO\ncomputer\tO\ninstead\tO\nof\tO\nbuying\tO\nan\tO\nadditional\tO\nTV\tO\nfor\tO\nyour\tO\ndorm\tO\nroom\tO\n.\tO\n\nSmall\tO\nand\tO\nlight\tO\nweight\tO\n.\tO\n\nGreat\tO\nlaptop\tO\nfor\tO\nschool\tO\n,\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nfor\tO\nbeginners\tO\nin\tO\nthe\tO\nhousehold\tO\n.\tO\n\nHe\tO\ndid\tO\nn't\tO\nwork\tO\nfor\tO\nsony\tO\n,\tO\nhe\tO\nwas\tO\njust\tO\napproved\tO\nto\tO\nfix\tO\ntheir\tO\ncrappy\tO\nproducts\tO\n.\tO\n\n4\tO\n)\tO\nLaptop\tO\nstill\tO\ndid\tO\nnot\tO\nwork\tB-aspectTerm\n,\tO\nblue\tO\nscreen\tO\nwithin\tO\na\tO\nweek\tO\n...\tO\n\nThe\tO\nonly\tO\nthing\tO\nthat\tO\nis\tO\nn't\tO\nperfect\tO\nabout\tO\nthis\tO\nnetbook\tO\nis\tO\nthe\tO\nspeakers\tB-aspectTerm\n,\tO\nthey\tO\nare\tO\nnot\tO\nloud\tO\nat\tO\nall\tO\nbut\tO\nI\tO\nexpected\tO\nthat\tO\n.\tO\n\nBought\tO\nfor\tO\nmy\tO\ndaughter\tO\nto\tO\ntake\tO\nfor\tO\nstarting\tO\ncollege\tO\nthis\tO\nfall\tO\n-\tO\nshe\tO\nhas\tO\nbeen\tO\non\tO\nit\tO\nnon\tO\n-\tO\nstop\tO\never\tO\nsince\tO\n\"\tO\nlearning\tO\nhow\tO\nto\tO\nuse\tO\nit\tO\n\"\tO\n.\tO\n\nNever\tO\nhad\tO\na\tO\nsingle\tO\nproblem\tO\n,\tO\nand\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tO\nabout\tO\nviruses\tO\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\ninspected\tO\nthe\tO\nother\tO\nnetbooks\tO\nand\tO\nclearly\tO\ntheir\tO\nhinges\tB-aspectTerm\nare\tO\ntighter\tO\nand\tO\nI\tO\neven\tO\ndemonstrate\tO\nthe\tO\ndifference\tO\nbetween\tO\nmy\tO\nnetbook\tO\nand\tO\nothers\tO\n.\tO\n\nNot\tO\nto\tO\nmention\tO\nthe\tO\nfact\tO\nthat\tO\nyour\tO\nmac\tO\ncomes\tO\nfully\tO\nloaded\tO\nwith\tO\nall\tO\nnecessary\tO\nbasic\tO\nprograms\tB-aspectTerm\n.\tO\n\nDid\tO\nn't\tO\nwork\tB-aspectTerm\nwhen\tO\nshipped\tO\nfrom\tO\nWalmart.com\tO\nbut\tO\nwent\tO\ninto\tO\na\tO\nstore\tO\nand\tO\nexchanged\tO\nfor\tO\na\tO\nworking\tO\nlaptop\tO\n(\tO\nsame\tO\nmake\tO\n/\tO\nmodel\tO\n)\tO\n.\tO\n\nIt\tO\nis\tO\nSO\tO\nmuch\tO\nfun\tO\nto\tO\nplay\tO\nwith\tO\n.\tO\n\nIf\tO\nthis\tO\nis\tO\nan\tO\nimprovement\tO\nin\tO\nCustomer\tB-aspectTerm\nService\tI-aspectTerm\nthen\tO\nI\tO\nwould\tO\nhate\tO\ntoo\tO\nsee\tO\nwhat\tO\nit\tO\nwas\tO\nbefore\tO\n!\tO\n\n*\tO\n6th\tO\nweek*-They\tO\nare\tO\nnot\tO\nresponding\tO\nto\tO\nmy\tO\nemails\tO\nasking\tO\nwhen\tO\nthey\tO\nexpect\tO\nto\tO\ndispatch\tO\nthe\tO\nnew\tO\nunit\tO\n...\tO\n\nAll\tO\nof\tO\nthe\tO\nprograms\tB-aspectTerm\n(\tO\nKeynote\tB-aspectTerm\n,\tO\nPages\tB-aspectTerm\n,\tO\nNumbers\tB-aspectTerm\n)\tO\nhave\tO\nan\tO\noption\tO\nto\tO\nsave\tO\nyour\tO\ndocuments\tO\nas\tO\nMicrosoft\tO\ncompatible\tO\n,\tO\nwhich\tO\nreally\tO\neliminates\tO\nthe\tO\nneed\tO\nfor\tO\nthe\tO\nactual\tO\n.\tO\n\nSure\tO\n,\tO\nthe\tO\ninitial\tO\nout\tO\nof\tO\npocket\tO\nexpense\tB-aspectTerm\nis\tO\ngreater\tO\n,\tO\nbut\tO\nthat\tO\nshould\tO\nnot\tO\ndissuade\tO\nanyone\tO\nfrom\tO\nthe\tO\nfact\tO\nthat\tO\nthese\tO\nmachines\tO\nrun\tB-aspectTerm\nlike\tO\nnone\tO\nother\tO\non\tO\nthe\tO\nplanet\tO\n,\tO\nand\tO\nwhen\tO\nI\tO\nfactor\tO\nin\tO\nall\tO\nthe\tO\nmoney\tO\nin\tO\nthat\tO\nI\tO\nwasted\tO\non\tO\nGeek\tO\nSquad\tO\nand\tO\nthe\tO\nlatest\tO\npatches\tO\nto\tO\nde\tO\n-\tO\ncorrupt\tO\nmy\tO\ninfested\tO\nPCs\tO\n,\tO\nit\tO\nprobably\tO\ncomes\tO\nout\tO\nabout\tO\neven\tO\nanyhow\tO\n.\tO\n\nThe\tO\nbest\tO\nthing\tO\nto\tO\ndo\tO\nis\tO\nbuild\tO\nyour\tO\nown\tO\ncomputer\tO\n,\tO\nbut\tO\nif\tO\nu\tO\nca\tO\nn't\tO\ncompany\tO\n's\tO\nlike\tO\ndell\tO\nwho\tO\nallow\tO\nyou\tO\nto\tO\nchoose\tO\nthe\tO\ncomponents\tB-aspectTerm\nare\tO\nbetter\tO\nand\tO\nfor\tO\nthe\tO\nsame\tO\nprice\tB-aspectTerm\nyou\tO\ncan\tO\nget\tO\na\tO\ncomputer\tO\nwho\tO\ncompares\tO\nto\tO\none\tO\nof\tO\napple\tO\n$\tO\n2000\tO\nsystems\tO\nand\tO\nif\tO\nyou\tO\ngoogle\tO\n\"\tO\ndell\tO\ncoupons\tO\n\"\tO\nyou\tO\ncan\tO\nfind\tO\ncodes\tO\nthat\tO\ntake\tO\na\tO\nsignifant\tO\namount\tO\noff\tO\nthe\tO\nprice\tO\n.\tB-aspectTerm\n\nThere\tO\nis\tO\nno\tO\ncd\tB-aspectTerm\ndrive\tI-aspectTerm\non\tO\nthe\tO\ncomputer\tO\n,\tO\nwhich\tO\ndefeats\tO\nthe\tO\npurpose\tO\nof\tO\nkeeping\tO\nfiles\tO\non\tO\na\tO\ncd\tO\n.\tO\n\nAnd\tO\nToshiba\tO\nis\tO\na\tO\nquality\tO\nsupplier\tO\n.\tO\n\nFor\tO\nme\tO\nI\tO\nwas\tO\nlucky\tO\nand\tO\na\tO\nlocal\tO\nstore\tO\nwas\tO\nselling\tO\nthem\tO\nfor\tO\n$\tO\n2000\tO\noff\tO\nand\tO\nBest\tO\nBuy\tO\nmatched\tO\ntheir\tO\nprice\tB-aspectTerm\nso\tO\nI\tO\nwas\tO\nable\tO\nto\tO\nbuy\tO\none\tO\nfor\tO\nunder\tO\n$\tO\n1000\tO\n\nI\tO\nca\tO\nn't\tO\nhonestly\tO\nsay\tO\nI\tO\nwas\tO\nheartbroken\tO\n.\tO\n\nWILL\tO\nNOT\tO\nEVERY\tO\nBUY\tO\nANOTHER--------LOU\tO\n\nUnfortunately\tO\n,\tO\nApple\tO\n's\tO\nquality\tB-aspectTerm\nhas\tO\ncontinued\tO\nto\tO\nslide\tO\n.\tO\n\nand\tO\nfinally\tO\ni\tO\nrealized\tO\nthat\tO\nmac\tO\nis\tO\nthe\tO\nbest\tO\n.\tO\n\nIt\tO\n's\tO\nvery\tO\nannoying\tO\n.\tO\n\nI\tO\n'm\tO\nhoping\tO\nthat\tO\nI\tO\ncan\tO\nfind\tO\na\tO\nreally\tO\nquick\tO\nway\tO\nto\tO\nclean\tO\nit\tO\nwithout\tO\nit\tO\ngetting\tO\ntoo\tO\ngross\tO\n.\tO\n\nMy\tO\nonly\tO\nother\tO\ncomplaint\tO\nis\tO\nthat\tO\nit\tO\ngets\tO\nreally\tO\nhot\tO\n.\tO\n\nI\tO\nbelieve\tO\nthat\tO\nthe\tO\nquality\tB-aspectTerm\nof\tO\na\tO\nmac\tO\nis\tO\nworth\tO\nthe\tO\nprice\tB-aspectTerm\n.\tO\n\nI\tO\n'm\tO\nVery\tO\ndisappointed\tO\nin\tO\nDell\tO\n.\tO\n\nsometimes\tO\nyou\tO\nwill\tO\nbe\tO\nmoving\tO\nyour\tO\nfinger\tO\nand\tO\nthe\tO\npointer\tB-aspectTerm\nwill\tO\nnot\tO\neven\tO\nmove\tO\n.\tO\n\nI\tO\n've\tO\nonly\tO\nhad\tO\nmine\tO\na\tO\nday\tO\nbut\tO\nI\tO\n'm\tO\nalready\tO\nused\tO\nto\tO\nit\tO\n...\tO\n\nAnd\tO\nthat\tO\nwas\tO\nthe\tO\nfourth\tO\ntime\tO\ni\tO\nve\tO\nsent\tO\nit\tO\nto\tO\nthem\tO\nto\tO\nget\tO\nfixed\tO\n.\tO\n\nThe\tO\n13\tO\n\"\tO\nMacbook\tO\nPro\tO\njust\tO\nfits\tO\nin\tO\nmy\tO\nbudget\tB-aspectTerm\nand\tO\nwith\tO\nfree\tO\nshipping\tB-aspectTerm\nand\tO\nno\tO\ntax\tO\nto\tO\nCA\tO\nthis\tO\nis\tO\nthe\tO\nbest\tO\nprice\tB-aspectTerm\nwe\tO\ncan\tO\nget\tO\nfor\tO\na\tO\ngreat\tO\nproduct\tO\n.\tO\n\nI\tO\nwould\tO\nrate\tO\nthis\tO\ncomputer\tO\nat\tO\n5\tO\nstars\tO\n,\tO\nbut\tO\nconsidering\tO\nit\tO\nhas\tO\na\tO\nshort\tO\nlife\tB-aspectTerm\nspan\tI-aspectTerm\nI\tO\ncan\tO\nonly\tO\ngive\tO\nit\tO\n1\tO\nand\tO\nimplore\tO\nanyone\tO\nlooking\tO\nat\tO\nlaptops\tO\nto\tO\nstay\tO\naway\tO\nfrom\tO\nthis\tO\nmachine\tO\n.\tO\n\nI\tO\nalso\tO\nlove\tO\nthe\tO\ndesign\tB-aspectTerm\n,\tO\nthe\tO\nlooks\tB-aspectTerm\n,\tO\nthe\tO\nfeel\tB-aspectTerm\n,\tO\nand\tO\nthe\tO\nmy\tB-aspectTerm\ntoshiba\tI-aspectTerm\nfeature\tI-aspectTerm\nis\tO\nwonderfull\tO\n.\tO\n\nFor\tO\nme\tO\n,\tO\nfive\tO\nstars\tO\nis\tO\nnot\tO\nenough\tO\n.\tO\n\nI\tO\nlove\tO\nhow\tO\neasy\tO\nevery\tO\nthing\tO\nis\tO\nto\tO\ndo\tO\non\tO\nmy\tO\nApple\tO\nproducts\tO\n.\tO\n\nSadly\tO\nApple\tO\nhas\tO\ndiscontinued\tO\nthis\tO\nMacBook\tO\n,\tO\nI\tO\nthink\tO\nit\tO\nwas\tO\nnever\tO\nsuper\tO\npopular\tO\nsince\tO\nit\tO\nfell\tO\nsomewhere\tO\nin\tO\nbetween\tO\nthe\tO\ncheapest\tO\nwhite\tO\nmodel\tO\nand\tO\nthe\tO\nsmaller\tO\nPros\tO\n.\tO\n\nThe\tO\nlayout\tB-aspectTerm\nof\tO\nthe\tO\nMacBook\tO\nis\tO\nhorrible\tO\nand\tO\nconfusing\tO\n;\tO\n\nWas\tO\nnot\tO\nhappy\tO\nwith\tO\none\tB-aspectTerm\nof\tI-aspectTerm\nthe\tI-aspectTerm\nprograms\tI-aspectTerm\non\tO\nit\tO\n.\tO\n\nAlso\tO\nit\tO\nis\tO\nvery\tO\ngood\tO\nfor\tO\ncollege\tO\nstudents\tO\nwho\tO\njust\tO\nneed\tO\na\tO\nreliable\tO\n,\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\ncomputer\tO\n.\tO\n\nThe\tO\nfirst\tO\none\tO\nsent\tO\n:\tO\nTouchpad\tB-aspectTerm\ndid\tO\nn't\tO\nwork\tO\nThe\tO\nsecond\tO\nsent\tO\n:\tO\nUSB\tB-aspectTerm\ndid\tO\nn't\tO\nwork\tO\nThe\tO\nthird\tO\nsent\tO\n:\tO\nTouchpad\tB-aspectTerm\ndid\tO\nn't\tO\nwork\tO\nThe\tO\nfourth\tO\nsent\tO\n:\tO\nHas\tO\nn't\tO\narrived\tO\nyet\tO\n.\tO\n\nI\tO\ncame\tO\nfrom\tO\nthe\tO\nDell\tO\nLaptops\tO\nand\tO\nnow\tO\nI\tO\nam\tO\nso\tO\nglad\tO\nI\tO\nswitched\tO\nwhen\tO\nI\tO\nneeded\tO\na\tO\nnew\tO\nlaptop\tO\n.\tO\n\nThis\tO\nis\tO\ndefinitely\tO\na\tO\ncomputer\tO\nworth\tO\nthe\tO\nmoney\tO\n;\tO\n\nOnly\tO\nother\tO\nthing\tO\nis\tO\nthat\tO\nif\tO\nyou\tO\nare\tO\nusing\tO\nthis\tO\nfor\tO\ndocument\tB-aspectTerm\ncreation\tI-aspectTerm\nApple\tO\ndoes\tO\nnt\tO\nprovide\tO\nany\tO\nkind\tO\nof\tO\nword\tB-aspectTerm\nprocessor\tI-aspectTerm\n(\tO\nsuch\tO\nas\tO\nworks\tO\nfor\tO\nwindows\tB-aspectTerm\n)\tO\n,\tO\nbut\tO\niwork\tB-aspectTerm\nis\tO\ncheap\tO\ncompared\tO\nto\tO\noffice\tB-aspectTerm\n.\tO\n\nI\tO\nam\tO\nstuck\tO\nwith\tO\na\tO\nlaptop\tO\nthat\tO\nI\tO\ncan\tO\nnot\tO\ndo\tO\nvery\tO\nmuch\tO\nwith\tO\n.\tO\n\nIt\tO\nis\tO\nlight\tO\nand\tO\nthe\tO\nbattery\tB-aspectTerm\nlast\tO\na\tO\nvery\tO\nlong\tO\ntime\tO\n.\tO\n\nBetter\tO\nstick\tO\nwith\tO\nanother\tO\nbrand\tO\n.\tO\n\nI\tO\nam\tO\nglad\tO\nI\tO\ndid\tO\nmy\tO\nresearch\tO\n.\tO\n\nAnd\tO\nat\tO\none\tO\npoint\tO\n,\tO\nthey\tO\nblame\tO\nme\tO\nfor\tO\ninstalling\tO\na\tO\nbad\tO\nmemory\tO\nstick\tB-aspectTerm\nwhen\tI-aspectTerm\nI\tO\nupgrade\tO\nmy\tO\nmemory\tO\nfor\tB-aspectTerm\nthe\tO\nfirst\tO\ntime\tO\nduring\tO\nmy\tO\npurchase\tO\nof\tO\nthe\tO\nlaptop\tO\n(\tO\nI\tO\nbought\tO\nthe\tO\nmemory\tO\nstick\tB-aspectTerm\nthey\tI-aspectTerm\nrecomended\tO\n)\tO\n.\tO\n\n5\tO\nmonths\tO\ndead\tO\nagain\tO\n.\tO\n\nAlso\tO\n,\tO\nyou\tO\nwo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tO\nabout\tO\nthem\tO\ngoing\tO\nonlne\tO\na\tO\ngetting\tO\na\tO\nvirus\tO\n.\tO\n\nVery\tO\nhappy\tO\n.\tO\n\nThe\tO\nnetbook\tO\nis\tO\neasier\tO\nfor\tO\nme\tO\nto\tO\ntake\tO\nto\tO\nbed\tO\nand\tO\ncarry\tO\naround\tO\nwith\tO\nme\tO\n.\tO\n\nExternally\tO\nthe\tO\nkeys\tB-aspectTerm\non\tO\nmy\tO\nkeyboard\tB-aspectTerm\nare\tO\nfalling\tO\noff\tO\n,\tO\nafter\tO\na\tO\nfew\tO\nuses\tO\nthe\tO\npaint\tB-aspectTerm\nis\tO\nrubbing\tO\noff\tO\nthe\tO\nbutton\tB-aspectTerm\nbelow\tI-aspectTerm\nthe\tI-aspectTerm\nmouse\tI-aspectTerm\npad\tI-aspectTerm\nand\tO\nwhere\tO\nthe\tO\nheals\tO\nof\tO\nmy\tO\nhands\tO\nsit\tO\n,\tO\nand\tO\nthe\tO\nscreen\tB-aspectTerm\nhas\tO\na\tO\nterrible\tO\nglare\tO\n.\tO\n\nMy\tO\nchildren\tO\nwo\tO\nn't\tO\neven\tO\nuse\tO\nit\tO\nfor\tO\ntheir\tO\nschool\tO\nwork\tO\n.\tO\n\nTHIS\tO\nLAPTOP\tO\nWAS\tO\nBAD\tO\nFROM\tO\nTHE\tO\nFIRST\tO\nDAY\tO\nOF\tO\nUSE----BROUGHT\tO\nIT\tO\nBACK\tO\nTO\tO\nSTORE\tO\nFOR\tO\nRETURN\tO\nOF\tO\nMONEY\tO\n.\tO\n\nThe\tO\nnext\tO\ntime\tO\nI\tO\nhad\tO\nan\tO\nissue\tO\nmy\tO\nlightscribe\tB-aspectTerm\nwould\tO\nn't\tO\nwork\tO\n.\tO\n\nThe\tO\ntouchpad\tB-aspectTerm\nis\tO\nextremely\tO\nsensitive\tO\n,\tO\nwhich\tO\nis\tO\nthe\tO\nonly\tO\ndrawback\tO\n.\tO\n\nalso\tO\nit\tO\ncomes\tO\nwith\tO\nvery\tO\nuseful\tO\napplications\tB-aspectTerm\nlike\tO\niphoto\tB-aspectTerm\nthat\tO\nit\tO\nis\tO\nthe\tO\nbest\tO\nphoto\tB-aspectTerm\napplication\tI-aspectTerm\ni\tO\nhave\tO\never\tO\nhad\tO\n\nIt\tO\nhas\tO\neverything\tO\nI\tO\nwould\tO\nneed\tO\nfor\tO\na\tO\nhome\tO\ncomputer\tO\n.\tO\n\nThe\tO\ncomputer\tO\ndid\tO\nwhat\tO\nit\tO\nwas\tO\nNOT\tO\nsupposed\tO\nto\tO\ndo\tO\n,\tO\nand\tO\nI\tO\ndid\tO\nn't\tO\nknow\tO\nwhat\tO\nto\tO\ndo\tO\n....\tO\n\nI\tO\nlove\tO\nthis\tO\ncomputer\tO\n.\tO\n\nThey\tO\ninformed\tO\nme\tO\nthat\tO\nI\tO\nhad\tO\naround\tO\n7\tO\n\"\tO\npolicies\tO\n\"\tO\nor\tO\nviruses\tO\non\tO\nit\tO\n.\tO\n\nThey\tO\ndon\tO\nt\tO\ntranslate\tO\nfrom\tO\na\tO\nMac\tO\n,\tO\neven\tO\non\tO\nWord\tB-aspectTerm\n,\tO\nresulting\tO\nin\tO\na\tO\nton\tO\nof\tO\nrun\tO\n-\tO\non\tO\nsentences\tO\n.\tO\n\nThe\tO\nacer\tO\none\tO\ncomputer\tO\nthat\tO\nI\tO\nbought\tO\nis\tO\n17\tB-aspectTerm\nince\tI-aspectTerm\nscreen\tI-aspectTerm\nand\tO\nits\tO\nhard\tO\nto\tO\nfind\tO\nlap\tO\ntop\tO\nbags\tO\nfor\tO\nit\tO\n,\tO\nbut\tO\nI\tO\nlike\tO\nthe\tO\nbig\tO\nscreen\tB-aspectTerm\non\tO\nit\tO\n.\tO\n\nSummary\tO\n:\tO\nThey\tO\nplayed\tO\ngames\tO\nwith\tO\nme\tO\nfor\tO\nthe\tO\nwarranty\tB-aspectTerm\nperiod\tI-aspectTerm\n.\tO\n\ni\tO\nca\tO\nnt\tO\nbelieve\tO\nHP\tO\nput\tO\nthis\tO\nout\tO\n.\tO\n\nIn\tO\nNovember\tO\nmy\tO\ncomputer\tO\nmessed\tO\nup\tO\nentirely\tO\nand\tO\nwould\tO\nn't\tO\npower\tO\non\tO\nafter\tO\nintalling\tO\na\tO\nWindows\tB-aspectTerm\nupdate\tI-aspectTerm\n,\tO\nI\tO\nhad\tO\nto\tO\nhave\tO\nmy\tO\nHD\tB-aspectTerm\nflashed\tO\nand\tO\nlost\tO\nEVERYTHING\tO\non\tO\nit\tO\n,\tO\nincluding\tO\nmy\tO\nschool\tO\nassignments\tO\nand\tO\nirriplaceable\tO\npictures\tO\nthat\tO\nwere\tO\nonly\tO\nin\tO\ndigital\tO\nformat\tO\nand\tO\nseveral\tO\nother\tO\nthings\tO\n,\tO\nwhen\tO\nthis\tO\nupdate\tO\nwas\tO\ninstalled\tO\nfor\tO\nsome\tO\nreason\tO\nI\tO\nwas\tO\nunable\tO\nto\tO\nroll\tO\nback\tO\nthe\tO\ndrivers\tB-aspectTerm\nand\tO\neverything\tO\nto\tO\nan\tO\nearlier\tO\nworking\tO\ncondition\tO\nbecause\tO\nwhen\tO\nthe\tO\nupdate\tO\nwas\tO\ninstalled\tO\nit\tO\ndeleted\tO\nmy\tO\nhistory\tO\n.\tO\n\nwithout\tO\na\tO\nbig\tO\nol'\tO\nclunky\tO\nmachine\tO\nin\tO\nmy\tO\nbackpack\tO\n,\tO\nI\tO\nfeel\tO\nlike\tO\nI\tO\ncan\tO\ndo\tO\nprogramming\tO\nhomework\tO\nanywhere\tO\n.\tO\n\nI\tO\ncan\tO\nhave\tO\nboth\tO\nOSX\tB-aspectTerm\nand\tO\nWindows\tB-aspectTerm\nXP\tI-aspectTerm\nrunning\tO\nat\tO\nthe\tO\nsame\tO\ntime\tO\n!\tO\n\nI\tO\ntell\tO\neveryone\tO\nthat\tO\nI\tO\nknow\tO\n,\tO\nfriends\tO\n,\tO\nfamily\tO\nand\tO\nenemies\tO\nthis\tO\nis\tO\nthe\tO\nabsolute\tO\nworst\tO\ncomputer\tO\ni\tO\nhave\tO\never\tO\nused\tO\n.\tO\n\nOverall\tO\n:\tO\nPoor\tO\n,\tO\nFeatures\tB-aspectTerm\n:\tO\nAverage\tO\n,\tO\nPerformance\tB-aspectTerm\n:\tO\nPoor\tO\n,\tO\nBattery\tB-aspectTerm\nLife\tI-aspectTerm\n:\tO\nExcellent\tO\n,\tO\nPrice\tB-aspectTerm\n-\tO\nValue\tB-aspectTerm\n:\tO\nPoor\tO\n\nOtherwise\tO\n,\tO\nI\tO\nlove\tO\nit\tO\n!\tO\n\nHaving\tO\nsomeone\tO\ngive\tO\nyou\tO\na\tO\nquick\tO\ntour\tO\nof\tO\nhow\tO\nto\tO\n's\tO\nis\tO\nthe\tO\nbest\tO\n.\tO\n\nI\tO\nhave\tO\nrecently\tO\nconverted\tO\nback\tO\nto\tO\na\tO\nmac\tO\nand\tO\nI\tO\ncould\tO\nn't\tO\nbe\tO\nhappier\tO\n!\tO\n\nMicrosoft\tO\nseems\tO\nto\tO\nbe\tO\nunable\tO\nto\tO\nkeep\tO\nup\tO\nwith\tO\nrepairs\tO\nfor\tO\nthe\tO\nmultitude\tO\nof\tO\nwindows\tB-aspectTerm\nproblems\tO\n.\tO\n\nAt\tO\n16\tO\nmonths\tO\nit\tO\nstarted\tO\nshutting\tO\noff\tO\nafter\tO\nonly\tO\n5\tO\nor\tO\n10\tO\nminutes\tO\n.\tO\n\nThey\tO\nbasically\tO\ntold\tO\nme\tO\nthat\tO\nthe\tO\nmachine\tO\nwould\tO\nbe\tO\nproblem\tO\nfree\tO\nnow\tO\n.\tO\n\nI\tO\npaid\tO\nabout\tO\n18000\tO\nfor\tO\nthis\tO\nlaptop\tO\nbecause\tO\nof\tO\nall\tO\nthe\tO\nbells\tO\nand\tO\nwhistles\tO\nand\tO\nit\tO\nkept\tO\ncrapping\tO\nout\tO\non\tO\nme\tO\n.\tO\n\nThe\tO\ngraphics\tB-aspectTerm\nare\tO\nstunning\tO\n.\tO\n\n(\tO\nI\tO\nfound\tO\na\tO\n2\tO\nGB\tO\nstick\tO\nfor\tO\na\tO\nbit\tO\nunder\tO\n$\tO\n50\tO\n)\tO\nNice\tO\nand\tO\nportable\tO\nand\tO\ndefinitely\tO\na\tO\ndecent\tO\nenough\tO\nsystem\tB-aspectTerm\nto\tO\nkeep\tO\nyou\tO\nentertained\tO\nwhile\tO\nsitting\tO\nin\tO\nthe\tO\nairplane\tO\nfor\tO\na\tO\ncouple\tO\nof\tO\nhours\tO\n,\tO\nor\tO\nat\tO\nthe\tO\nhotel\tO\ntaking\tO\ncare\tO\nof\tO\nsome\tO\nlast\tO\nminute\tO\ndetails\tO\nand\tO\ndocuments\tO\n.\tO\n\nafter\tO\nmuch\tO\neffort\tO\nand\tO\n10\tO\ndays\tO\nASUS\tO\nreplaced\tO\nitThe\tO\nWiFi\tB-aspectTerm\nis\tO\nvery\tO\nweak\tO\n.\tO\n\nYou\tO\ncan\tO\ncall\tO\nHP\tO\nand\tO\nthey\tO\nwant\tO\nyou\tO\nto\tO\nbuy\tO\nmore\tO\nsoftware\tB-aspectTerm\nto\tO\nfix\tO\nit\tO\n.\tO\n\nIt\tO\nhas\tO\nbeen\tO\nplagued\tO\nwith\tO\nproblems\tO\nsince\tO\nthe\tO\nday\tO\ni\tO\nturned\tO\nit\tO\non\tO\n.\tO\n\nthis\tO\ncomputer\tO\nis\tO\na\tO\nlittle\tO\nmore\tO\nexpensive\tO\nthan\tO\nany\tO\npc\tO\nbut\tO\nit\tO\nwill\tO\nlast\tO\nyou\tO\nlonger\tO\nand\tO\nit\tO\nworth\tO\nevery\tO\npenny\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\nnavigate\tB-aspectTerm\nand\tO\nupdate\tB-aspectTerm\nprograms\tI-aspectTerm\n.\tO\n\nThe\tO\nlaptop\tO\nis\tO\ngorgeous\tO\n.\tO\n\nIt\tO\n's\tO\nmore\tO\nexpensive\tO\nbut\tO\nwell\tO\nworth\tO\nit\tO\nin\tO\nthe\tO\nlong\tO\nrun\tO\n.\tO\n\nI\tO\n'm\tO\nmaking\tO\nthe\tO\nswitch\tO\nand\tO\nfinding\tO\nthat\tO\nmy\tO\nbiggest\tO\nproblem\tO\nis\tO\ntrying\tO\nto\tO\ndo\tO\nthings\tO\nthe\tO\n'\tO\nold\tO\n'\tO\nway\tO\n-\tO\nand\tO\nApple\tO\ndoes\tO\n,\tO\nindeed\tO\n,\tO\nhave\tO\nthe\tO\nbetter\tO\nidea\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nhp\tO\ndesktop\tO\nfor\tO\nover\tO\n4\tO\nyrs\tO\nnow\tO\nand\tO\nnot\tO\none\tO\ndays\tO\ngoes\tO\nby\tO\nthat\tO\ni\tO\ndo\tO\nn't\tO\nregret\tO\nbuying\tO\nit\tO\n.\tO\n\nHP\tO\ndid\tO\nn't\tO\nfix\tO\nit\tO\n.\tO\n\n,\tO\nApplications\tB-aspectTerm\nrespond\tO\nimmediately\tO\n(\tO\nnot\tO\nlike\tO\nthe\tO\ntired\tO\nMS\tB-aspectTerm\napplications\tI-aspectTerm\n)\tO\n.\tO\n\nAll\tO\nin\tO\nall\tO\n,\tO\na\tO\nvery\tO\ndisappointing\tO\nexperience\tO\nexcept\tO\nthat\tO\nI\tO\nlearned\tO\nhow\tO\ngood\tO\nthe\tO\nGeek\tO\nSquad\tO\nis\tO\nand\tO\nalso\tO\nCustomer\tB-aspectTerm\nService\tI-aspectTerm\n.\tO\n\nNow\tO\n,\tO\nI\tO\nguess\tO\n,\tO\nI\tO\n'll\tO\nhave\tO\nto\tO\nunload\tO\nmy\tO\nM6809\tO\non\tO\nsome\tO\npoor\tO\n,\tO\nhapless\tO\nsoul\tO\n.\tO\n\nThe\tO\nonly\tO\ndrawback\tO\nfor\tO\nme\tO\nis\tO\nhow\tO\ndirty\tO\nthe\tO\nscreen\tB-aspectTerm\ngets\tO\n,\tO\nand\tO\nrather\tO\nquickly\tO\ntoo\tO\n.\tO\n\nThe\tO\nlaptop\tO\nis\tO\nvery\tO\nlightweight\tO\n,\tO\ncan\tO\neasily\tO\ncarry\tB-aspectTerm\naround\tO\nin\tO\na\tO\nknapsack\tO\nfull\tO\nof\tO\ntext\tO\nbooks\tO\nand\tO\nit\tO\nbarely\tO\nadds\tO\nany\tO\nweight\tB-aspectTerm\n.\tO\n\nSeems\tO\nto\tO\nslow\tO\ndown\tO\noccassionally\tO\nbut\tO\ncan\tO\nrun\tO\nmany\tO\napplications\tB-aspectTerm\n(\tO\nie\tO\nInternet\tB-aspectTerm\ntabs\tI-aspectTerm\n,\tO\nprograms\tB-aspectTerm\n,\tO\netc\tO\n)\tO\nsimultaneously\tO\n.\tO\n\nThe\tO\nproblems\tO\nstarted\tO\nwith\tO\njust\tO\nthe\tO\nscreen\tO\nfreezing\tO\n.\tO\n\nTaking\tO\nit\tO\nanywhere\tO\nwas\tO\na\tO\npain\tO\n!\tO\n\nI\tO\nalso\tO\ndid\tO\nnot\tO\nlike\tO\nthe\tO\nloud\tO\nnoises\tB-aspectTerm\nit\tO\nmade\tO\nor\tO\nhow\tO\nthe\tO\nbottom\tB-aspectTerm\nof\tI-aspectTerm\nthe\tI-aspectTerm\ncomputer\tI-aspectTerm\nwould\tO\nget\tO\nreally\tO\nhot\tO\n.\tO\n\nI\tO\nhad\tO\nin\tO\nthe\tO\npast\tO\na\tO\nDell\tO\nlaptop\tO\nand\tO\nthey\tO\nsent\tO\nme\tO\nthe\tO\nitems\tO\nit\tO\nneeded\tO\nor\tO\nthey\tO\nsent\tO\na\tO\nrepair\tB-aspectTerm\ntechnician\tI-aspectTerm\nto\tO\nmy\tO\nhouse\tO\nto\tO\nfix\tO\nit\tO\n.\tO\n\nI\tO\npreviously\tO\nowned\tO\na\tO\nToshiba\tO\nand\tO\nit\tO\nonly\tO\nlasted\tO\nabout\tO\n2\tO\nyears\tO\n.\tO\n\nI\tO\nca\tO\nn't\tO\nimagine\tO\nmy\tO\nlife\tO\nwithout\tO\nit\tO\nanymore\tO\n!\tO\n\ndefective\tO\nsoftware\tB-aspectTerm\n.\tO\n\nThis\tO\ncomputer\tO\nwas\tO\nso\tO\nchallenging\tO\nto\tO\ncarry\tB-aspectTerm\nand\tO\nhandle\tB-aspectTerm\n.\tO\n\nCords\tB-aspectTerm\ncoming\tO\nout\tO\nthe\tO\nright\tO\nfor\tO\npower\tB-aspectTerm\nplus\tO\ncords\tB-aspectTerm\ncoming\tO\nout\tO\nfront\tO\nfor\tO\nheadphones\tB-aspectTerm\n/\tO\nmic\tB-aspectTerm\nplus\tO\nnetwork\tB-aspectTerm\nconnection\tI-aspectTerm\non\tO\nleft\tO\nmake\tO\nfor\tO\na\tO\nvery\tO\nmessy\tO\nsetup\tB-aspectTerm\nwith\tO\ncords\tB-aspectTerm\ngoing\tO\nevery\tO\ndirection\tO\n.\tO\n\nUnless\tO\nyou\tO\nwant\tO\nto\tO\nbe\tO\ninconvenienced\tO\nwith\tO\na\tO\nnon\tO\nworking\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nwhich\tO\nyou\tO\nca\tO\nn't\tO\nfind\tO\na\tO\nreplacement\tO\nfor\tO\nbecause\tO\nthey\tO\nmade\tO\nthe\tO\nattachment\tO\nso\tO\nsmall\tO\n.\tO\n\nIt\tO\nis\tO\nmuch\tO\nfaster\tO\nthan\tO\nmy\tO\ndesktop\tO\nwhich\tO\nis\tO\na\tO\nCore2\tB-aspectTerm\nQuad\tI-aspectTerm\nrunning\tO\nat\tO\n2.83\tO\nGHz\tO\n.\tO\n\nIt\tO\nis\tO\ngood\tO\nto\tO\nknow\tO\nthat\tO\nI\tO\ncan\tO\nmobilize\tO\nwithout\tO\nhaving\tO\nto\tO\nworry\tO\nabout\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nI\tO\nbaby\tO\nmy\tO\nelectronics\tO\nso\tO\nI\tO\nknow\tO\nfor\tO\na\tO\nfact\tO\nit\tO\nwas\tO\ndefective\tO\nand\tO\nnot\tO\nanything\tO\nthat\tO\nI\tO\ndid\tO\nto\tO\nit\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nnice\tO\n,\tO\nside\tO\nview\tO\nangles\tO\nare\tO\npretty\tO\ngood\tO\n.\tO\n\nThe\tO\nfact\tO\nthat\tO\nthe\tO\nscreen\tB-aspectTerm\nreacts\tO\nto\tO\nthe\tO\nlighting\tO\naround\tO\nyou\tO\nis\tO\nan\tO\nadded\tO\nluxury\tO\n-\tO\nwhen\tO\nyou\tO\nare\tO\nworking\tO\naround\tO\nothers\tO\nin\tO\ndark\tO\nareas\tO\nand\tO\nwant\tO\nprivacy\tO\nor\tO\ndo\tO\nn't\tO\nwant\tO\nto\tO\nbother\tO\nthem\tO\nwith\tO\nbright\tO\nlighting\tO\n,\tO\nit\tO\nis\tO\nvery\tO\nconvenient\tO\nto\tO\nhave\tO\na\tO\ndarker\tO\n,\tO\nsofter\tO\nlit\tO\nscreen\tB-aspectTerm\n.\tO\n\n3\tO\nweeks\tO\nwent\tO\nby\tO\nand\tO\nthe\tO\ncomputer\tO\nkeeps\tO\ncrashing\tO\nand\tO\nwill\tO\nnot\tO\nopen\tO\nany\tO\napplications\tB-aspectTerm\n.\tO\n\nNot\tO\nto\tO\nmention\tO\nsometimes\tO\nthe\tO\nwhole\tO\ncharger\tB-aspectTerm\nunit\tI-aspectTerm\nwill\tO\ndecide\tO\nnot\tO\nto\tO\nwork\tO\nentirely\tO\n.\tO\n\nLooks\tB-aspectTerm\nnice\tO\n,\tO\nbut\tO\nhas\tO\na\tO\nhorribly\tO\ncheap\tO\nfeel\tB-aspectTerm\n.\tO\n\nI\tO\nwould\tO\nrecommend\tO\nnot\tO\nbuying\tO\nthis\tO\nproduct\tO\n.\tO\n\nits\tO\nmore\tO\nlike\tO\na\tO\nsnail\tO\ncrawl\tO\n.\tO\n\nI\tO\nhave\tO\nother\tO\ncomputers\tO\nthat\tO\nget\tO\nstrong\tO\nsignals\tB-aspectTerm\nthat\tO\ndo\tO\nn't\tO\ndrop\tO\nin\tO\nplaces\tO\nthat\tO\nthis\tO\n\"\tO\nnet\"book\tO\nloses\tO\nits\tO\nsignal\tB-aspectTerm\n.\tO\n\nThe\tO\nfeel\tB-aspectTerm\nof\tO\nthis\tO\nis\tO\nbetter\tO\nthan\tO\nthe\tO\nToshiba\tO\n,\tO\ntoo\tO\n.\tO\n\nI\tO\nwould\tO\nrecommend\tO\nthis\tO\nlaptop\tO\nto\tO\nanyone\tO\nlooking\tO\nto\tO\nget\tO\na\tO\nnew\tO\nlaptop\tO\nwho\tO\nis\tO\nwilling\tO\nto\tO\nspend\tO\na\tO\nlittle\tO\nmore\tO\nmoney\tO\nto\tO\nget\tO\ngreat\tO\nquality\tB-aspectTerm\n!\tO\n\nI\tO\nupgraded\tO\nthe\tO\nmemory\tB-aspectTerm\nand\tO\nreplaced\tO\nthe\tO\nbase\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nStarter\tI-aspectTerm\nto\tO\nWin\tB-aspectTerm\n7\tI-aspectTerm\nHome\tI-aspectTerm\n,\tO\nand\tO\nit\tO\nruns\tB-aspectTerm\njust\tO\nfine\tO\n.\tO\n\nI\tO\nam\tO\nnot\tO\nsure\tO\nif\tO\nit\tO\nwas\tO\nthe\tO\ndrive\tB-aspectTerm\nitself\tO\n,\tO\nhowever\tO\n;\tO\n\nSo\tO\nI\tO\ncalled\tO\n,\tO\nAGAIN\tO\n.\tO\n\nAlso\tO\n,\tO\none\tO\nof\tO\nthe\tO\nusers\tO\nmentioned\tO\nhow\tO\nthe\tO\nedges\tB-aspectTerm\non\tO\nthe\tO\nmacbook\tO\nis\tO\nsharp\tO\n,\tO\nif\tO\nyou\tO\nhave\tO\nmoney\tO\nto\tO\nspend\tO\non\tO\none\tO\nof\tO\nthe\tO\nincase\tB-aspectTerm\nshells\tI-aspectTerm\n,\tO\nit\tO\ndoes\tO\nn't\tO\nseem\tO\nto\tO\nbe\tO\na\tO\nproblem\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nits\tO\nkeyboard\tB-aspectTerm\neasily\tO\naccommodates\tO\nlarge\tO\nhands\tO\n,\tO\nand\tO\nits\tO\nweight\tB-aspectTerm\nis\tO\nfantasic\tO\n.\tO\n\nCalled\tO\nAcer\tO\nmany\tO\ntimes\tO\n,\tO\nthey\tO\nwant\tO\nme\tO\nto\tO\npay\tO\nthe\tO\nshipping\tB-aspectTerm\nto\tO\nship\tO\nit\tO\nto\tO\ntheir\tO\nrepair\tB-aspectTerm\ncenter\tI-aspectTerm\n-\tO\nI\tO\nwas\tO\nvery\tO\ndisappointed\tO\nsince\tO\nit\tO\nis\tO\na\tO\nbrand\tO\nnew\tO\ncomputer\tO\n!\tO\n\nI\tO\nwas\tO\nconstantly\tO\nhaving\tO\nto\tO\nroll\tO\nback\tO\nthe\tO\ncomputer\tO\nafter\tO\ndoing\tO\nupdates\tO\n.\tO\n\nStay\tO\naway\tO\nfrom\tO\nEnvy\tO\n.\tO\n\n-got\tO\nit\tO\nback\tO\n3\tO\nmonths\tO\nlater\tO\n\nI\tO\nhave\tO\nhad\tO\nto\tO\nsend\tO\nin\tO\nmy\tO\nlaptop\tO\nthree\tO\ntimes\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\n.\tO\n\nWhen\tO\nI\tO\nturned\tO\nit\tO\non\tO\n,\tO\nnothing\tO\n.\tO\n\nI\tO\nshould\tO\nhave\tO\nchecked\tO\nthis\tO\nbefore\tO\nI\tO\ninstalled\tO\nmy\tO\napplications\tB-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nis\tO\nreally\tO\nlong\tO\n.\tO\n\nAnyway\tO\n,\tO\nin\tO\nearly\tO\nJuly\tO\nof\tO\nthis\tO\nyear\tO\n,\tO\nthe\tO\nDVD\tB-aspectTerm\nburner\tI-aspectTerm\nstopped\tO\nworking\tO\n,\tO\nand\tO\nthe\tO\ncomputer\tO\nstared\tO\nhaving\tO\nissues\tO\nwith\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\n.\tO\n\nHad\tO\nsome\tO\ntrouble\tO\nfinding\tO\na\tO\ncase\tB-aspectTerm\nthat\tO\nit\tO\nwould\tO\nfit\tO\nin\tO\n.\tO\n\nThe\tO\n17\tO\nin\tO\nMacbook\tO\nPro\tO\nhas\tO\nbeen\tO\na\tO\nwonderful\tO\naddition\tO\n.\tO\n\nThis\tO\ncomputer\tO\nthat\tO\nI\tO\nhave\tO\nhas\tO\nhad\tO\nissues\tO\nwith\tO\nthe\tO\nkeyboard\tB-aspectTerm\nwhere\tO\nit\tO\nlost\tO\nhalf\tO\nthe\tO\nkeyboard\tB-aspectTerm\nfunctions\tI-aspectTerm\n.\tO\n\n1st\tO\ntime\tO\nthey\tO\ngot\tO\nit\tO\nworking\tO\nthe\tO\nnext\tO\n5\tO\nmonth\tO\nthey\tO\nhad\tO\nme\tO\nsend\tO\nit\tO\nin\tO\n.\tO\n\nComes\tO\nwith\tO\niMovie\tB-aspectTerm\n;\tO\n\nI\tO\njust\tO\nlove\tO\nmy\tO\nMac\tO\n!\tO\n\nI\tO\ncan\tO\nnot\tO\neven\tO\nread\tO\nwhat\tO\nI\tO\nam\tO\nwriting\tO\nhalf\tO\nof\tO\nthe\tO\ntime\tO\n.\tO\n\nMACS\tO\nARE\tO\nAMAZING\tO\n!\tO\n!\tO\n!\tO\n\nMy\tO\nhp\tO\nG60\tO\n-\tO\n244dx\tO\ndied\tO\nafter\tO\nonly\tO\n16\tO\nmonths\tO\n.\tO\n\nThey\tO\nfreeze\tO\nall\tO\nthe\tO\ntime\tO\n.\tO\n\nthis\tO\none\tO\n,\tO\nin\tO\nmy\tO\nopinion\tO\n,\tO\nmight\tO\nbe\tO\na\tO\nlemon\tO\n!\tO\n\nThe\tO\nbook\tO\nis\tO\nuseless\tO\n.\tO\n\nCOMPUTER\tO\nHAS\tO\nBEEN\tO\nAT\tO\nSERVICE\tB-aspectTerm\nFACILITY\tI-aspectTerm\nMORE\tO\nTHAN\tO\nIN\tO\nMY\tO\nHANDS\tO\n.\tO\n\nThis\tO\nlaptop\tO\nis\tO\nvery\tO\nlarge\tO\nand\tO\nbarely\tO\nfits\tO\nin\tO\nany\tO\ncarrying\tO\ncases\tO\n.\tO\n\nWhen\tO\nI\tO\ncalled\tO\nSony\tO\nthe\tO\nCustomer\tB-aspectTerm\nService\tI-aspectTerm\nwas\tO\nGreat\tO\n.\tO\n\neven\tO\nthough\tO\nI\tO\nhad\tO\nthe\tO\nreceipt\tO\nin\tO\nfront\tO\nof\tO\nme\tO\nproving\tO\nit\tO\nstill\tO\nhad\tO\n2\tO\nmonths\tO\nleft\tO\non\tO\nthe\tO\nwarranty\tO\n.\tB-aspectTerm\n\nI\tO\nsent\tO\nit\tO\nto\tO\nthem\tO\nto\tO\nfix\tO\nin\tO\nperfect\tO\ncondition\tO\nbut\tO\nfor\tO\nwhat\tO\nwas\tO\nwrong\tO\nwith\tO\nit\tO\n.\tO\n\nIt\tO\nis\tO\na\tO\nmuch\tO\nmore\tO\nstreamlined\tO\nsystem\tB-aspectTerm\nfor\tO\nadding\tO\nprograms\tB-aspectTerm\n,\tO\nusing\tB-aspectTerm\nthe\tI-aspectTerm\ninternet\tI-aspectTerm\n,\tO\nand\tO\ndoing\tO\nother\tO\nthings\tO\neveryone\tO\ndoes\tO\non\tO\na\tO\ncomputer\tO\n.\tO\n\nMy\tO\ncomputer\tO\nfroze\tO\non\tO\nseveral\tO\noccasion\tO\n,\tO\nhad\tO\nbuttons\tB-aspectTerm\nthat\tO\nrandomely\tO\nwould\tO\nfall\tO\noff\tO\nand\tO\neven\tO\nhad\tO\nmoments\tO\nwhen\tO\nthe\tO\ncomputer\tO\nwould\tO\nrefuse\tO\nto\tO\nturn\tO\non\tO\nat\tO\nall\tO\n.\tO\n\nNot\tO\neven\tO\nsafe\tB-aspectTerm\nmode\tI-aspectTerm\nboots\tO\n.\tO\n\nWhich\tO\nwas\tO\nway\tO\ntoo\tO\nmuch\tO\nmoney\tO\n.\tO\n\nTo\tO\nthose\tO\nthinking\tO\nabout\tO\nswitching\tO\n,\tO\ndo\tO\nit\tO\nand\tO\ndo\tO\nnot\tO\nlook\tO\nback\tO\n!\tO\n\nThis\tO\nis\tO\nan\tO\nover\tO\n-\tO\nsized\tO\n,\tO\n18-inch\tB-aspectTerm\nlaptop\tO\n.\tO\n\nI\tO\nhad\tO\nto\tO\npay\tO\n$\tO\n100\tO\nfor\tO\na\tO\nuniversal\tB-aspectTerm\ncharger\tI-aspectTerm\nfor\tO\nthis\tO\ncheap\tO\n$\tO\n300\tO\nlaptop\tO\n.\tO\n\nThe\tO\npowerpoint\tB-aspectTerm\nopened\tO\nseamlessly\tO\nin\tO\nthe\tO\napple\tO\nand\tO\nthe\tO\nmac\tO\nhooked\tO\nup\tO\nto\tO\nthe\tO\nprojector\tO\nso\tO\neasily\tO\nit\tO\nwas\tO\nalmost\tO\nscary\tO\n.\tO\n\n1.You\tO\ncan\tO\nnot\tO\nchange\tO\nyour\tO\ndesktop\tB-aspectTerm\nbackground\tI-aspectTerm\n(\tO\nwindow\tB-aspectTerm\n's\tI-aspectTerm\n7\tI-aspectTerm\nstarter\tI-aspectTerm\ndoes\tO\nNOT\tO\nsupport\tO\nthat\tO\nfunction\tB-aspectTerm\n)\tO\n.\tO\n\nTook\tO\nme\tO\n11\tO\nhours\tO\n,\tO\n3\tO\ntrips\tO\nto\tO\ndifferent\tO\nFedEx\tO\noffices\tO\n,\tO\nand\tO\nbrutal\tO\nconversations\tO\nwith\tO\n14\tO\nof\tO\nthe\tO\nworse\tO\nIT\tB-aspectTerm\nsupport\tI-aspectTerm\ntechnicians\tI-aspectTerm\nin\tO\nthe\tO\nworld\tO\n.\tO\n\nThen\tO\nafter\tO\n4\tO\nor\tO\nso\tO\nmonths\tO\nthe\tO\ncharger\tB-aspectTerm\nstopped\tO\nworking\tO\nso\tO\nI\tO\nwas\tO\nforced\tO\nto\tO\ngo\tO\nout\tO\nand\tO\nbuy\tO\nnew\tO\nhardware\tB-aspectTerm\njust\tO\nto\tO\nkeep\tO\nthis\tO\ncomputer\tO\nrunning\tO\n.\tO\n\nOne\tO\nyear\tO\nof\tO\ntrying\tO\nto\tO\nfix\tO\nthe\tO\ncomputer\tO\nby\tO\nmyself\tO\n,\tO\nwith\tO\nhelp\tO\nof\tO\nfriends\tO\n,\tO\nand\tO\neven\tO\nhelp\tO\nfrom\tO\ncomputer\tO\nexperts\tO\nI\tO\nhave\tO\ngiven\tO\nup\tO\non\tO\ntrying\tO\nto\tO\nfix\tO\nit\tO\n.\tO\n\nAs\tO\nusual\tO\nat\tO\ncustomer\tB-aspectTerm\nservice\tI-aspectTerm\ncenter\tI-aspectTerm\n,\tO\nshe\tO\nasked\tO\nme\tO\nto\tO\nhold\tO\nfor\tO\na\tO\nmoment\tO\nwhile\tO\nshe\tO\nwent\tO\nto\tO\nthe\tO\nback\tO\n-\tO\noffice\tO\nand\tO\ncompare\tO\nit\tO\nwith\tO\nother\tO\nsame\tO\nmodel\tO\nnetbooks\tO\nand\tO\ndiscussed\tO\nit\tO\nwith\tO\nher\tO\ncolleague\tO\n(\tO\nI\tO\ncould\tO\nsee\tO\nthem\tO\n)\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\ngets\tO\nsmeary\tO\nand\tO\ndusty\tO\nvery\tO\nquickly\tO\nand\tO\nit\tO\n's\tO\nvery\tO\nnoticeable\tO\n.\tO\n\nIt\tO\nall\tO\njust\tO\nmakes\tO\nsense\tO\n.\tO\n\n2\tO\n)\tO\nBlue\tO\nscreen\tO\nfirst\tO\nmonth\tO\n\nI\tO\nlove\tO\nit\tO\nso\tO\nmuch\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nfor\tO\nChristmas\tO\n,\tO\nand\tO\nI\tO\nwas\tO\nso\tO\nexcited\tO\nto\tO\nset\tO\nit\tO\nup\tO\n!\tO\n\nStrengths\tO\n:\tO\nWell\tO\n-\tO\nshaped\tB-aspectTerm\nWeaknesses\tO\n:\tO\nA\tO\nbad\tO\nvideocard\tB-aspectTerm\n!\tO\n\nYou\tO\nca\tO\nn't\tO\neven\tO\nget\tO\na\tO\nsatellite\tB-aspectTerm\ncard\tI-aspectTerm\nwhich\tO\nis\tO\nwhy\tO\nI\tO\nbought\tO\nto\tO\nbegin\tO\nwith\tO\n.\tO\n\nI\tO\nuse\tO\nit\tO\nnow\tO\nmore\tO\nthan\tO\nI\tO\neven\tO\nthought\tO\nI\tO\nwould\tO\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n,\tO\nbefore\tO\nthe\tO\nbattery\tB-aspectTerm\ncompletely\tO\ndied\tO\nof\tO\ncourse\tO\n,\tO\nleft\tO\nmuch\tO\nto\tO\nbe\tO\ndesired\tO\n.\tO\n\nDo\tO\nyourself\tO\na\tO\nfavor\tO\n,\tO\nthis\tO\nis\tO\nnot\tO\na\tO\nfake\tO\nstory\tO\ntrying\tO\nto\tO\nhurt\tO\nalienware\tO\n...\tO\n\nIt\tO\nis\tO\na\tO\nREAL\tO\ntouchpad\tB-aspectTerm\n,\tO\nnot\tO\nthe\tO\ntoy\tO\nI\tO\nsaw\tO\nin\tO\nother\tO\nbrands\tO\n.\tO\n\nIt\tO\nhas\tO\nworked\tO\nfine\tO\n.\tO\n\nThe\tO\nmost\tO\namazing\tO\npart\tO\nto\tO\nme\tO\nas\tO\na\tO\nPC\tO\nuser\tO\nis\tO\nthe\tO\nstartup\tO\nand\tO\nshutdown\tO\ntimes\tO\n-\tO\nand\tO\nthe\tO\nfact\tO\nthat\tO\nyou\tO\nvery\tO\nrarely\tO\nhave\tO\nto\tO\nrestart\tO\nthe\tO\nthing\tO\n.\tO\n\nLong\tO\nstory\tO\n,\tO\nbut\tO\nafter\tO\nmany\tO\ncalls\tO\nto\tO\nvarious\tO\noffices\tO\n,\tO\nI\tO\nwas\tO\ntold\tO\nthat\tO\nno\tO\none\tO\ncan\tO\noverride\tO\nthe\tO\ndepot\tO\nand\tO\nthat\tO\nmanagers\tO\ndo\tO\nn't\tO\ntake\tO\nphone\tO\ncalls\tO\nor\tO\ne\tO\n/\tO\nmails\tO\n.\tO\n\nI\tO\ncan\tO\nthrow\tO\nanything\tO\nat\tO\nit\tO\n(\tO\nand\tO\nI\tO\ndo\tO\n)\tO\n,\tO\nPictures\tO\n,\tO\nvideo\tO\nediting\tO\n,\tO\nschoolwork\tO\n.\tO\n\nPrice\tB-aspectTerm\nand\tO\npurpose\tO\nis\tO\nawesome\tO\n!\tO\n\nWonderful\tO\nzooming\tB-aspectTerm\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nhuge\tO\nand\tO\ncoloful\tO\n,\tO\nbut\tO\nno\tO\nLED\tO\nbacklighting\tO\n.\tO\n\nthe\tO\ntwo\tO\nof\tO\nus\tO\nuse\tO\nit\tO\nregularly\tO\n.\tO\n\nIn\tO\nall\tO\nhonesty\tO\n,\tO\nif\tO\nsomeone\tO\nis\tO\nlooking\tO\nfor\tO\na\tO\nquality\tO\nlaptop\tO\nand\tO\nwilling\tO\nto\tO\npay\tO\na\tO\nlittle\tO\nmore\tO\nmoney\tO\nfor\tO\na\tO\nnormal\tO\nsized\tB-aspectTerm\nlaptop\tO\nthan\tO\na\tO\ncheaper\tO\nand\tO\nless\tO\nimpressive\tO\nlaptop\tO\n,\tO\nthen\tO\ndo\tO\nnot\tO\nbuy\tO\nthis\tO\ncomputer\tO\n.\tO\n\nEverything\tO\nabout\tO\nthis\tO\ncomputer\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nAfter\tO\npaying\tO\nover\tO\n$\tO\n1000\tO\nfor\tO\nthis\tO\ncomputer\tO\n,\tO\nit\tO\nwas\tO\nnot\tO\nworth\tO\nit\tO\n.\tO\n\nWorse\tO\n,\tO\nfor\tO\nthe\tO\nprice\tO\nI\tB-aspectTerm\ncould\tO\nget\tO\na\tO\n*\tO\nnetbook\tO\n*\tO\nthat\tO\noutperforms\tO\nthis\tO\nmachine\tO\n.\tO\n\nVery\tO\nhappy\tO\nwith\tO\nmy\tO\n7th\tO\nToshiba\tO\nlaptop\tO\n!\tO\n\nMy\tO\nwife\tO\nrecently\tO\npurchased\tO\nan\tO\nApple\tO\nMacBook\tO\nPro\tO\nand\tO\nour\tO\ngranddaughter\tO\nfell\tO\nin\tO\nlove\tO\nwith\tO\nit\tO\nand\tO\nasked\tO\nfor\tO\none\tO\nfor\tO\nher\tO\nbirthday\tO\n.\tO\n\nIt\tO\nhad\tO\nmost\tO\nof\tO\nthe\tO\nfeatures\tB-aspectTerm\nand\tO\nall\tO\nof\tO\nthe\tO\npower\tB-aspectTerm\nthat\tO\nI\tO\nwanted\tO\nto\tO\nreplace\tO\nmy\tO\ndesktop\tO\nmachine\tO\n.\tO\n\nKeyboard\tB-aspectTerm\nwas\tO\nalso\tO\nvery\tO\nnice\tO\nand\tO\nhad\tO\na\tO\nsolid\tO\nfeel\tO\n.\tO\n\nI\tO\nwill\tO\nonly\tO\nbuy\tO\napple\tO\nlaptops\tO\nfrom\tO\nnow\tO\non\tO\n.\tO\n\nI\tO\nwould\tO\ndefinitely\tO\nsuggest\tO\nthis\tO\nlaptop\tO\n!\tO\n\nIt\tO\ndid\tO\nnot\tO\nhave\tO\nall\tO\nthe\tO\nfeatures\tB-aspectTerm\nI\tO\nexpected\tO\nit\tO\nto\tO\nhave\tO\n.\tO\n\nJust\tO\na\tO\nbunch\tO\nof\tO\nidiots\tO\nwho\tO\n's\tO\nEnglish\tO\nas\tO\na\tO\n5th\tO\nlanguage\tO\nis\tO\nforced\tO\nat\tO\nbest\tO\n.\tO\n\nNo\tO\nluck\tO\n,\tO\nalthough\tO\nI\tO\nwaited\tO\nfor\tO\nhours\tO\non\tO\nthe\tO\nphone\tO\n-\tO\nVisited\tO\nMacHouse\tO\n,\tO\nthey\tO\nstated\tO\nthe\tO\ntheir\tO\ncall\tB-aspectTerm\ncenter\tI-aspectTerm\nis\tO\ndown\tO\ndue\tO\nto\tO\ntoo\tO\nmany\tO\nphonecalls\tO\n(\tO\ndifficult\tO\nto\tO\nbelieve\tO\n)\tO\n.\tO\n\nThere\tO\nis\tO\na\tO\nbacklit\tB-aspectTerm\nkeyboard\tI-aspectTerm\nwhich\tO\nis\tO\nperfect\tO\nfor\tO\ntyping\tO\nin\tO\nthe\tO\ndark\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\nlot\tO\nof\tO\nmemory\tB-aspectTerm\nand\tO\na\tO\ngreat\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nI\tO\nspoke\tO\nwith\tO\na\tO\nservice\tB-aspectTerm\nrep\tI-aspectTerm\nat\tO\nMicro\tO\nCenter\tO\nand\tO\nhis\tO\ngirlfriend\tO\nis\tO\nhaving\tO\nthe\tO\nsame\tO\nproblem\tO\nwith\tO\nher\tO\npower\tB-aspectTerm\nadapter\tI-aspectTerm\n,\tO\nso\tO\nit\tO\n's\tO\nnot\tO\njust\tO\nan\tO\nisolated\tO\nincident\tO\n!\tO\n!\tO\n!\tO\n\nThey\tO\nhad\tO\nme\tO\nsend\tO\nin\tO\nthe\tO\nmachine\tO\nlast\tO\nApril\tO\nreturned\tO\nit\tO\nto\tO\nme\tO\nin\tO\nMay\tO\nwith\tO\nno\tO\ndocumentation\tO\non\tO\nwhat\tO\nwas\tO\ndone\tO\nit\tO\nanything\tO\n.\tO\n\n5\tO\n)\tO\nCut\tO\nmy\tO\nlosses\tO\nand\tO\nsold\tO\nit\tO\nfor\tO\nparts\tO\n\nAll\tO\nI\tO\ncan\tO\nsay\tO\nis\tO\nW\tO\n-\tO\nO\tO\n-\tO\nW.\tO\n\nI\tO\nlove\tO\nthis\tO\nprogram\tB-aspectTerm\n,\tO\nit\tO\nis\tO\nsuperior\tO\nto\tO\nwindows\tB-aspectTerm\nmovie\tI-aspectTerm\nmaker\tI-aspectTerm\n.\tO\n\nWhich\tO\nis\tO\nwhat\tO\nI\tO\ndid\tO\n,\tO\ncheck\tO\nout\tO\nmy\tO\nACER\tO\n5517\tO\n!\tO\n\nHe\tO\nhas\tO\nreplaced\tO\nhis\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\ntwice\tO\nand\tO\n(\tO\nof\tO\ncourse\tO\n)\tO\nhas\tO\nhad\tO\nto\tO\npay\tO\nfor\tO\nantivirus\tB-aspectTerm\nsoftware\tI-aspectTerm\nevery\tO\nyear\tO\n.\tO\n\nThis\tO\npurchase\tO\nopened\tO\nme\tO\nto\tO\nthe\tO\nworld\tO\nof\tO\nMacbooks\tO\n,\tO\nand\tO\nI\tO\nam\tO\nimpressed\tO\nwith\tO\nthe\tO\nintuition\tO\nof\tO\nthe\tO\ndesign\tB-aspectTerm\n,\tO\nthe\tO\nbeauty\tB-aspectTerm\nof\tO\nthe\tO\nproduct\tO\n,\tO\nand\tO\nthe\tO\nexcellent\tO\ntechnological\tO\nadvances\tO\nassociated\tO\nwith\tO\nit\tO\n.\tO\n\nI\tO\nhave\tO\nloved\tO\nthis\tO\nsince\tO\ni\tO\ntook\tO\nit\tO\nout\tO\nof\tO\nthe\tO\nbox\tO\n.\tO\n\nThe\tO\nprice\tB-aspectTerm\nis\tO\ngreat\tO\nfor\tO\nthis\tO\nmodel\tO\n,\tO\nI\tO\nonly\tO\nplan\tO\non\tO\nusing\tO\nit\tO\nfor\tO\nmedia\tO\nin\tO\nthe\tO\nentertainment\tO\nroom\tO\n.\tO\n\nIt\tO\nseemed\tO\nto\tO\nbe\tO\na\tO\nvery\tO\nnice\tO\nlaptop\tO\nexcept\tO\nI\tO\nwas\tO\nnot\tO\nable\tO\nto\tO\nload\tO\nmy\tO\nGarmin\tB-aspectTerm\nGPS\tI-aspectTerm\nsoftware\tI-aspectTerm\nor\tO\nMicrosoft\tB-aspectTerm\nOffice\tI-aspectTerm\n2003\tI-aspectTerm\n.\tO\n\nBut\tO\n,\tO\nlike\tO\nI\tO\nsaid\tO\nbefore\tO\n,\tO\nthe\tO\nonly\tO\nreason\tO\nI\tO\ndo\tO\nn't\tO\ncurrently\tO\nhave\tO\na\tO\nMac\tO\nlaptop\tO\nis\tO\nbecause\tO\nall\tO\nof\tO\ntheir\tO\nlaptops\tO\nare\tO\ntoo\tO\npricey\tO\n.\tO\n\nI\tO\n've\tO\nalso\tO\nhad\tO\nto\tO\nhave\tO\nthe\tO\nkeyboard\tB-aspectTerm\nreplaced\tO\nat\tO\nmy\tO\nexpense\tO\n.\tO\n\nI\tO\nhad\tO\nthe\tO\nstaff\tB-aspectTerm\ntelling\tO\nme\tO\nolder\tO\nversion\tO\ndid\tO\nnot\tO\nmake\tO\nthe\tO\nfan\tB-aspectTerm\nnoise\tI-aspectTerm\ncause\tO\nit\tO\nis\tO\na\tO\n\"\tO\ndifferent\tO\n\"\tO\ncomputer\tO\n.\tO\n\nWas\tO\nvery\tO\nmuch\tO\nworth\tO\nthe\tO\nprice\tB-aspectTerm\ni\tO\npaid\tO\n.\tO\n\nSo\tO\nfar\tO\n,\tO\nso\tO\ngood\tO\n.\tO\n\nEven\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\n!\tO\n\nA\tO\ntip\tO\nfor\tO\npeople\tO\nlooking\tO\ninto\tO\nthis\tO\ncomputer\tO\n:\tO\nDO\tO\nNOT\tO\nBUY\tO\nIT\tO\nsave\tO\nup\tO\na\tO\nbit\tO\nmore\tO\nmoney\tO\nand\tO\nbuy\tO\na\tO\ncomputer\tO\nthat\tO\nwill\tO\nlast\tO\n.\tO\n\nThis\tO\nis\tO\na\tO\ngreat\tO\nlittle\tO\ncomputer\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n.\tO\n\nThis\tO\ncomes\tO\nin\tO\nvery\tO\nhandy\tO\nfor\tO\nme\tO\nas\tO\nan\tO\neducator\tO\n.\tO\n\nCrisp\tO\nscreen\tB-aspectTerm\n,\tO\ngreat\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n,\tO\nand\tO\nplenty\tO\nof\tO\nstorage\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\na\tO\nlong\tO\nand\tO\ntirring\tO\nprocess\tO\nthat\tO\nafter\tO\na\tO\nwhile\tO\nit\tO\nseems\tO\nlike\tO\ntheir\tO\ngame\tO\nplan\tO\nwas\tO\nto\tO\nwear\tO\nyou\tO\nout\tO\nso\tO\nyou\tO\nwould\tO\nwant\tO\nto\tO\ngive\tO\nup\tO\non\tO\ncontacting\tO\nthem\tO\n.\tO\n\nAll\tO\napple\tB-aspectTerm\nassociates\tI-aspectTerm\nare\tO\nalways\tO\nwiling\tO\nto\tO\nhelp\tO\nyou\tO\nout\tO\nwith\tO\nanything\tO\n,\tO\nno\tO\nmatter\tO\nwhen\tO\nyou\tO\npurchased\tO\nthe\tO\ncomputer\tO\nand\tO\nhow\tO\nmany\tO\nyears\tO\npassed\tO\n.\tO\n\nI\tO\nwas\tO\nwaiting\tO\nfor\tO\nthis\tO\nmodel\tO\nto\tO\nbe\tO\nreleased\tO\nsince\tO\nJanuary\tO\n,\tO\nand\tO\nhave\tO\nbeen\tO\nholding\tO\noff\tO\non\tO\nbuying\tO\na\tO\nMacbook\tO\nPro\tO\nuntil\tO\nthe\tO\nnew\tO\nmodel\tO\ncame\tO\nout\tO\n.\tO\n\nI\tO\nwill\tO\nnever\tO\nbuy\tO\nanother\tO\nHP\tO\ncomputer\tO\n.\tO\n\nSo\tO\ni\tO\nwould\tO\nnot\tO\nreccomend\tO\nanyone\tO\nbuying\tO\nthis\tO\ncomputer\tO\n\nYou\tO\nwill\tO\nregret\tO\nit\tO\nif\tO\nyou\tO\nbuy\tO\nany\tO\ndell\tO\n.\tO\n\ni\tO\nthink\tO\nthat\tO\nanyone\tO\nlooking\tO\nfor\tO\na\tO\ngood\tO\ndurrable\tO\nlaptop\tO\nthen\tO\nthis\tO\nis\tO\nthe\tO\nway\tO\nto\tO\ngo\tO\n.\tO\n\nAlso\tO\n,\tO\nmy\tO\nsister\tO\ngot\tO\nthe\tO\nexact\tO\nsame\tO\nlaptop\tO\n(\tO\nsince\tO\nthey\tO\nwere\tO\nso\tO\ncheap\tO\n)\tO\nand\tO\nafter\tO\n8\tO\nmonths\tO\n,\tO\nthe\tO\nscreen\tB-aspectTerm\nsplit\tO\nin\tO\nhalf\tO\njust\tO\nfrom\tO\neveryday\tO\nuse\tO\n.\tO\n\nIt\tO\nstarted\tO\nout\tO\ngetting\tO\nhot\tO\nafter\tO\nonly\tO\na\tO\nfew\tO\nmonths\tO\n.\tO\n\nThe\tO\nToshiba\tO\nSatellite\tO\nhas\tO\nbeen\tO\nmore\tO\nthan\tO\nI\tO\nexpected\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n.\tO\n\nI\tO\nhad\tO\nto\tO\nadjust\tO\nmy\tO\nmousepad\tB-aspectTerm\nsensitivity\tI-aspectTerm\n,\tO\nbecause\tO\nit\tO\nis\tO\nvery\tO\nsensitive\tO\n.\tO\n\nI\tO\nwish\tO\niWork\tB-aspectTerm\nor\tO\nMS\tB-aspectTerm\nOffice\tI-aspectTerm\ncame\tO\nwith\tO\nthe\tO\nMac\tO\n,\tO\nbut\tO\nMS\tB-aspectTerm\nOffice\tI-aspectTerm\ndoes\tO\nn't\tO\neven\tO\ncome\tO\nwith\tO\nmost\tO\npc\tO\nlaptops\tO\n.\tO\n\nTo\tO\nmy\tO\nmind\tO\nmuch\tO\nmore\tO\nusable\tO\nthan\tO\nthe\tO\ntoy\tO\ncalled\tO\nan\tO\nIPad\tO\n.\tO\n\nIt\tO\nallows\tO\nme\tO\nto\tO\ndo\tO\neverything\tO\nI\tO\nneed\tO\nfrom\tO\na\tO\ncomputer\tO\nand\tO\nmore\tO\n.\tO\n\nThe\tO\nbest\tO\nthing\tO\nis\tO\neven\tO\nwhile\tO\ndoing\tO\nalmost\tO\nten\tO\nor\tO\ntwenty\tO\nthings\tO\nat\tO\nonce\tO\n,\tO\nit\tO\nnever\tO\nslows\tO\ndown\tO\n.\tO\n\nKeyboard\tB-aspectTerm\nis\tO\nplastic\tO\nand\tO\nspongey\tO\nfeeling\tO\n.\tO\n\n,\tO\nwhich\tO\nApple\tO\ndoes\tO\nn't\tO\noffer\tO\n,\tO\nis\tO\nwhy\tO\nI\tO\nbought\tO\nmy\tO\nMacBook\tO\nat\tO\nBest\tO\nBuy\tO\n.\tO\n\nprevious\tO\nlaptops\tO\nwere\tO\npc\tO\n's\tO\n,\tO\nstill\tO\nhave\tO\nthem\tO\n,\tO\nbut\tO\nthe\tO\nmac\tB-aspectTerm\nosx\tI-aspectTerm\nis\tO\na\tO\nclean\tO\nand\tO\nsmooth\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n.\tO\n\nThe\tO\ncomputer\tO\nis\tO\na\tO\ndream\tO\ncome\tO\ntrue\tO\n.\tO\n\ni\tO\nalso\tO\nlove\tO\nhaving\tO\nthe\tO\nextra\tO\ncalculator\tO\nnumber\tO\nset\tO\nup\tO\non\tO\nthe\tO\nkeyboard\tB-aspectTerm\nwhich\tO\nmost\tO\nlaptops\tO\ndo\tO\nnot\tO\nhave\tO\n.\tO\n\nI\tO\n'm\tO\nglad\tO\nI\tO\nmade\tO\nthe\tO\nchoice\tO\nto\tO\nswitch\tO\nand\tO\nbuy\tO\nthis\tO\nMAC\tO\n.\tO\n\nBecause\tO\nhe\tO\nsaid\tO\nthat\tO\nthe\tO\nhinge\tB-aspectTerm\nis\tO\nunder\tO\nthe\tO\nmotherboard\tB-aspectTerm\nand\tO\nthey\tO\nhave\tO\nto\tO\ndismantle\tO\nthe\tO\nwhole\tO\nthing\tO\nbefore\tO\nit\tO\ncan\tO\nbe\tO\ntightened\tO\n.\tO\n\nYou\tO\ncan\tO\ndo\tO\nit\tO\nall\tO\non\tO\nthis\tO\nbad\tO\nboy\tO\nbut\tO\nthe\tO\nmain\tO\nthing\tO\nthis\tO\nnetbook\tO\nwas\tO\ndesinged\tO\nfor\tO\nwas\tO\nsurfing\tB-aspectTerm\nthe\tI-aspectTerm\nweb\tI-aspectTerm\nand\tO\nboy\tO\no\tO\nboy\tO\ndoes\tO\nit\tO\never\tO\n.\tO\n\nI\tO\nlove\tO\nmy\tO\nApple\tO\n,\tO\nit\tO\nis\tO\nquick\tO\nand\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nI\tO\ntook\tO\nit\tO\nto\tO\nthe\tO\nshop\tO\nand\tO\nthey\tO\nsaid\tO\nIt\tO\nwould\tO\ncost\tO\ntoo\tO\nmuch\tO\nto\tO\nrepair\tO\nit\tO\n.\tO\n\nDid\tO\nn't\tO\nexpect\tO\nto\tO\nrepair\tO\nit\tO\nat\tO\nonce\tO\n!\tO\n\nIt\tO\nis\tO\nquiet\tO\nand\tO\na\tO\nreal\tO\njoy\tO\nto\tO\nwatch\tO\nwork\tO\n.\tO\n\nWith\tO\nnotes\tO\nsaying\tO\nthey\tO\nreplaced\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n.\tO\n\nThe\tO\nlaptop\tO\nis\tO\nrelatively\tO\nsimple\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nthough\tO\nI\tO\nbought\tO\nMacs\tO\nfor\tO\nDummies\tO\n,\tO\nwhich\tO\nis\tO\nwell\tO\nworth\tO\n$\tO\n2\tO\n\nCa\tO\nn't\tO\nclose\tO\nthe\tO\n2nd\tO\nHDD\tB-aspectTerm\nbay\tI-aspectTerm\nsince\tO\nthere\tO\nare\tO\nbrackets\tO\nyou\tO\nhave\tO\nto\tO\nbreak\tO\noff\tO\n(\tO\neven\tO\nthen\tO\n,\tO\nit\tO\nstill\tO\ndoes\tO\nn't\tO\nshut\tO\n)\tO\nThat\tO\ncould\tO\nbe\tO\na\tO\nmajor\tO\nflaw\tO\nfor\tO\nthe\tO\ndual\tO\nHDD\tO\nuser\tO\n.\tO\n\nFrom\tO\nthe\tO\nstart\tO\n,\tO\nwhen\tO\nyou\tO\nopen\tO\nthe\tO\nbox\tO\nyou\tO\nsee\tO\na\tO\ncompletely\tO\ndifferent\tO\nclass\tO\nof\tO\nmachine\tO\n.\tO\n\nNo\tO\ntutorials\tB-aspectTerm\non\tO\nthe\tO\ndisplay\tO\n.\tO\n\nThe\tO\nleather\tB-aspectTerm\ncarrying\tI-aspectTerm\ncase\tI-aspectTerm\n,\tO\nkeyboard\tB-aspectTerm\nand\tO\nmouse\tB-aspectTerm\narrived\tO\nin\tO\ntwo\tO\ndays\tO\nfrom\tO\nMemphis\tO\nwarehouse\tO\n.\tO\n\nThe\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\nis\tO\namong\tO\nthe\tO\nbest\tO\n.\tO\n\nVery\tO\nvery\tO\ndisappointed\tO\n!\tO\n\nIf\tO\nyou\tO\nare\tO\na\tO\nperson\tO\nlike\tO\nme\tO\n,\tO\nmore\tO\non\tO\nthe\tO\ncreative\tO\nside\tO\n,\tO\nthe\tO\nmac\tO\nhas\tO\nsomething\tO\nfor\tO\nyou\tO\ntoo\tO\n.\tO\n\nI\tO\nhad\tO\nto\tO\nhave\tO\nthese\tO\ncomputers\tO\nin\tO\nmy\tO\nschool\tO\n.\tO\n\nThus\tO\n,\tO\nwhen\tO\nyou\tO\ncarry\tO\nit\tO\nat\tO\na\tO\nslanted\tO\nangle\tO\n,\tO\nthe\tO\nscreen\tB-aspectTerm\nwill\tO\n\"\tO\ntopple\tO\n\"\tO\nor\tO\n\"\tO\nslide\tO\n\"\tO\ndown\tO\n,\tO\nif\tO\nyou\tO\nunderstand\tO\nwhat\tO\nI\tO\nmean\tO\n.\tO\n\nAgain\tO\n.\tO\n\nTo\tO\nthis\tO\nday\tO\n,\tO\nthere\tO\nare\tO\nNONE\tO\n.\tO\n\ni\tO\nsetup\tO\nmy\tO\npassword\tO\nlast\tO\nnight\tO\nwith\tO\nthe\tO\npassword\tO\non\tO\nmy\tO\nother\tO\ncomputer\tO\n.\tO\n\nit\tO\nis\tO\nan\tO\namazing\tO\nimage\tO\nand\tO\nit\tO\ntoo\tO\nis\tO\nholding\tO\nup\tO\nquite\tO\nnicely\tO\nto\tO\nlittle\tO\nhands\tO\ngrabbing\tO\nthe\tO\nback\tO\nof\tO\nmy\tO\nlaptop\tO\n.\tO\n\nfirst\tO\ni\tO\nhave\tO\nbeen\tO\nsearching\tO\nfor\tO\nlong\tO\ntime\tO\nbefore\tO\ni\tO\ndecided\tO\nto\tO\nget\tO\nmac\tO\n.\tO\n\nIt\tO\n's\tO\nnow\tO\nall\tO\ncommodity\tB-aspectTerm\nhardware\tI-aspectTerm\n.\tO\n\nWe\tO\nalso\tO\nuse\tO\nParalles\tB-aspectTerm\nso\tO\nwe\tO\ncan\tO\nrun\tO\nvirtual\tO\nmachines\tO\nof\tO\nWindows\tB-aspectTerm\nXP\tI-aspectTerm\nProfessional\tI-aspectTerm\n,\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nHome\tI-aspectTerm\nPremium\tI-aspectTerm\n,\tO\nWindows\tB-aspectTerm\nServer\tI-aspectTerm\nEnterprise\tI-aspectTerm\n2003\tI-aspectTerm\n,\tO\nand\tO\nWindows\tB-aspectTerm\nServer\tI-aspectTerm\n2008\tI-aspectTerm\nEnterprise\tI-aspectTerm\n.\tO\n\nI\tO\nwas\tO\nso\tO\nexcited\tO\nwhen\tO\nmy\tO\ndad\tO\nsaid\tO\ni\tO\ncould\tO\nget\tO\na\tO\nnew\tO\nlaptop\tO\nfor\tO\nmy\tO\nbirthday\tO\n.\tO\n\nWe\tO\npurchased\tO\nthis\tO\nas\tO\na\tO\nback\tO\nup\tO\ncomputer\tO\nafter\tO\nour\tO\nmore\tO\nexpensive\tO\nHP\tO\nneeded\tO\nto\tO\nbe\tO\nrepaired\tO\n.\tO\n\n-They\tO\nreported\tO\nthat\tO\nthe\tO\ncomputer\tO\nis\tO\nin\tO\ntheir\tO\nheadquarters\tO\n.\tO\n\nbought\tO\nnotebook\tO\n07/2009\tO\n.\tO\n\nHow\tO\nToshiba\tO\nhandles\tO\nthe\tO\nrepair\tB-aspectTerm\nseems\tO\nto\tO\nvary\tO\n,\tO\nsome\tO\nfolks\tO\nindicate\tO\nthat\tO\nthey\tO\nwere\tO\ncharged\tO\nfor\tO\neven\tO\nan\tO\nintial\tO\nfix\tO\n,\tO\nothers\tO\nhad\tO\nthe\tO\nrepair\tO\ndone\tB-aspectTerm\n5\tO\ntimes\tO\n.\tO\n\nI\tO\nwould\tO\nlike\tO\nto\tO\nuse\tO\na\tO\ndifferent\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\naltogether\tO\n.\tO\n\nAll\tO\nof\tO\nthem\tO\nwere\tO\nWindows\tO\nmachines\tO\n.\tO\n\nWell\tO\n,\tO\nI\tO\nhad\tO\ncompleted\tO\nthe\tO\npresentation\tO\nin\tO\npowerpoint\tO\nthe\tO\nnight\tO\nbefore\tO\non\tO\nmy\tO\nPC\tO\n,\tO\nbut\tO\ntook\tO\nthe\tO\nApple\tO\nto\tO\nthe\tO\nconference\tO\n.\tO\n\nThe\tO\nlatest\tO\nand\tO\nmightiest\tO\nMacbook\tO\npro\tO\n17-inch\tO\nwas\tO\nbought\tO\nby\tO\nmy\tO\nuniversity\tO\non\tO\nthe\tO\n30th\tO\nof\tO\nJune\tO\n2009\tO\n.\tO\n\nI\tO\nhave\tO\na\tO\nbusiness\tO\nwebsite\tO\nand\tO\nevery\tO\ntime\tO\nI\tO\nhave\tO\nto\tO\nchange\tO\nsomething\tO\nI\tO\nhave\tO\nto\tO\ngo\tO\nto\tO\nthe\tO\npublic\tO\nlibrary\tO\nto\tO\nuse\tO\na\tO\nPC\tO\n.\tO\n\nI\tO\npaid\tO\nabout\tO\nthe\tO\nsame\tO\nfor\tO\nmy\tO\nToshiba\tO\nas\tO\nI\tO\ndid\tO\nfor\tO\nthe\tO\ncompaq\tO\na\tO\nfew\tO\nyears\tO\nback\tO\n.\tO\n\nThis\tO\nwas\tO\nan\tO\nupdate\tO\nfrom\tO\nan\tO\nearly\tO\nMacBook\tO\nPro\tO\n.\tO\n\nI\tO\nthink\tO\nI\tO\nmight\tO\nrather\tO\nsuffer\tO\nfor\tO\nsomething\tO\nthat\tO\nis\tO\nsimple\tO\nto\tO\nfix\tO\nin\tO\nmy\tO\nopinion\tO\n.\tO\n\n"
  },
  {
    "path": "dataset/Laptop-reviews/train_20.txt",
    "content": "I\tO\ncharge\tO\nit\tO\nat\tO\nnight\tO\nand\tO\nskip\tO\ntaking\tO\nthe\tO\ncord\tB-aspectTerm\nwith\tO\nme\tO\nbecause\tO\nof\tO\nthe\tO\ngood\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nThe\tO\ntech\tB-aspectTerm\nguy\tI-aspectTerm\nthen\tO\nsaid\tO\nthe\tO\nservice\tB-aspectTerm\ncenter\tI-aspectTerm\ndoes\tO\nnot\tO\ndo\tO\n1-to-1\tO\nexchange\tO\nand\tO\nI\tO\nhave\tO\nto\tO\ndirect\tO\nmy\tO\nconcern\tO\nto\tO\nthe\tO\n\"\tB-aspectTerm\nsales\tI-aspectTerm\n\"\tI-aspectTerm\nteam\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\nthe\tO\nretail\tO\nshop\tO\nwhich\tO\nI\tO\nbought\tO\nmy\tO\nnetbook\tO\nfrom\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tB-aspectTerm\n,\tO\nhas\tO\na\tO\nkiller\tO\nGUI\tB-aspectTerm\n,\tO\nis\tO\nextremely\tO\nstable\tO\n,\tO\nis\tO\nhighly\tO\nexpandable\tO\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tB-aspectTerm\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nfeatures\tB-aspectTerm\nthat\tO\nit\tO\noffers\tO\n,\tO\nlike\tO\n,\tO\niChat\tB-aspectTerm\n,\tO\nPhotobooth\tB-aspectTerm\n,\tO\ngarage\tB-aspectTerm\nband\tI-aspectTerm\nand\tO\nmore\tO\n!\tO\n\nGreat\tO\nlaptop\tO\nthat\tO\noffers\tO\nmany\tO\ngreat\tO\nfeatures\tB-aspectTerm\n!\tO\n\nÂ\tO\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tB-aspectTerm\n,\tO\nscreen\tB-aspectTerm\nall\tO\ndark\tO\n,\tO\npower\tB-aspectTerm\nlight\tI-aspectTerm\nsteady\tO\n,\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nlight\tI-aspectTerm\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tO\n\nI\tO\ntook\tO\nit\tO\nback\tO\nfor\tO\nan\tO\nAsus\tO\nand\tO\nsame\tO\nthing-\tO\nblue\tO\nscreen\tO\nwhich\tO\nrequired\tO\nme\tO\nto\tO\nremove\tO\nthe\tO\nbattery\tB-aspectTerm\nto\tO\nreset\tO\n.\tO\n\nIn\tO\nthe\tO\nshop\tO\n,\tO\nthese\tO\nMacBooks\tO\nare\tO\nencased\tO\nin\tO\na\tO\nsoft\tO\nrubber\tB-aspectTerm\nenclosure\tI-aspectTerm\n-\tO\nso\tO\nyou\tO\nwill\tO\nnever\tO\nknow\tO\nabout\tO\nthe\tO\nrazor\tO\nedge\tB-aspectTerm\nuntil\tO\nyou\tO\nbuy\tO\nit\tO\n,\tO\nget\tO\nit\tO\nhome\tO\n,\tO\nbreak\tO\nthe\tO\nseal\tO\nand\tO\nuse\tO\nit\tO\n(\tO\nvery\tO\nclever\tO\ncon\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\ngestures\tI-aspectTerm\nand\tO\nlarge\tO\ntracking\tB-aspectTerm\narea\tI-aspectTerm\nmake\tO\nhaving\tO\nan\tO\nexternal\tB-aspectTerm\nmouse\tI-aspectTerm\nunnecessary\tO\n(\tO\nunless\tO\nyou\tO\n're\tO\ngaming\tB-aspectTerm\n)\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nway\tO\nthe\tO\nentire\tO\nsuite\tB-aspectTerm\nof\tI-aspectTerm\nsoftware\tI-aspectTerm\nworks\tO\ntogether\tO\n.\tO\n\nThe\tO\nspeed\tB-aspectTerm\nis\tO\nincredible\tO\nand\tO\nI\tO\nam\tO\nmore\tO\nthan\tO\nsatisfied\tO\n.\tO\n\nThis\tO\nlaptop\tO\nmeets\tO\nevery\tO\nexpectation\tO\nand\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nis\tO\ngreat\tO\n!\tO\n\nI\tO\ncan\tO\nbarely\tO\nuse\tO\nany\tO\nusb\tB-aspectTerm\ndevices\tI-aspectTerm\nbecause\tO\nthey\tO\nwill\tO\nnot\tO\nstay\tO\nconnected\tO\nproperly\tO\n.\tO\n\nWhen\tO\nI\tO\nfinally\tO\nhad\tO\neverything\tO\nrunning\tO\nwith\tO\nall\tO\nmy\tO\nsoftware\tB-aspectTerm\ninstalled\tO\nI\tO\nplugged\tO\nin\tO\nmy\tO\ndroid\tO\nto\tO\nrecharge\tO\nand\tO\nthe\tO\nsystem\tB-aspectTerm\ncrashed\tO\n.\tO\n\nOne\tO\nsuggestion\tO\nI\tO\ndo\tO\nhave\tO\n,\tO\nis\tO\nto\tO\nnot\tO\nbother\tO\ngetting\tO\nMicrosoft\tB-aspectTerm\noffice\tI-aspectTerm\nfor\tI-aspectTerm\nthe\tI-aspectTerm\nmac\tI-aspectTerm\nexpecting\tO\nit\tO\nwill\tO\nwork\tO\njust\tO\nlike\tO\nyou\tO\nknew\tO\nit\tO\nto\tO\non\tO\na\tO\nPC\tO\n.\tO\n\nPairing\tO\nit\tO\nwith\tO\nan\tO\niPhone\tO\nis\tO\na\tO\npure\tO\npleasure\tO\n-\tO\ntalk\tO\nabout\tO\npainless\tO\nsyncing\tB-aspectTerm\n-\tO\nused\tO\nto\tO\ntake\tO\nme\tO\nforever\tO\n-\tO\nnow\tO\nit\tO\n's\tO\na\tO\nsnap\tO\n.\tO\n\nI\tO\nalso\tO\ngot\tO\nthe\tO\nadded\tO\nbonus\tO\nof\tO\na\tO\n30\tB-aspectTerm\n\"\tI-aspectTerm\nHD\tI-aspectTerm\nMonitor\tI-aspectTerm\n,\tO\nwhich\tO\nreally\tO\nhelps\tO\nto\tO\nextend\tO\nmy\tO\nscreen\tB-aspectTerm\nand\tO\nkeep\tO\nmy\tO\neyes\tO\nfresh\tO\n!\tO\n\nThe\tO\nmachine\tO\nis\tO\nslow\tO\nto\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nand\tO\noccasionally\tO\ncrashes\tO\ncompletely\tO\n.\tO\n\nAfter\tO\npaying\tO\nseveral\tO\nhundred\tO\ndollars\tO\nfor\tO\nthis\tO\nservice\tB-aspectTerm\n,\tO\nit\tO\nis\tO\nfrustrating\tO\nthat\tO\nyou\tO\ncan\tO\nnot\tO\nget\tO\nhelp\tO\nafter\tO\nhours\tO\n.\tO\n\nI\tO\ndid\tO\nhave\tO\nto\tO\nreplace\tO\nthe\tO\nbattery\tB-aspectTerm\nonce\tO\n,\tO\nbut\tO\nthat\tO\nwas\tO\nonly\tO\na\tO\ncouple\tO\nmonths\tO\nago\tO\nand\tO\nit\tO\n's\tO\nbeen\tO\nworking\tO\nperfect\tO\never\tO\nsince\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nand\tO\nthe\tO\npreloaded\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nThe\tO\nbest\tO\nthing\tO\nabout\tO\nthis\tO\nlaptop\tO\nis\tO\nthe\tO\nprice\tB-aspectTerm\nalong\tO\nwith\tO\nsome\tO\nof\tO\nthe\tO\nnewer\tO\nfeatures\tB-aspectTerm\n.\tO\n\nAfter\tO\nnumerous\tO\nattempts\tO\nof\tO\ntrying\tO\n(\tO\nincluding\tO\nsetting\tO\nthe\tO\nclock\tB-aspectTerm\nin\tI-aspectTerm\nBIOS\tI-aspectTerm\nsetup\tI-aspectTerm\ndirectly\tO\n)\tO\n,\tO\nI\tO\ngave\tO\nup(I\tO\nam\tO\na\tO\ntechie\tO\n)\tO\n.\tO\n\nYOU\tO\nWILL\tO\nNOT\tO\nBE\tO\nABLE\tO\nTO\tO\nTALK\tO\nTO\tO\nAN\tO\nAMERICAN\tO\nWARRANTY\tB-aspectTerm\nSERVICE\tI-aspectTerm\nIS\tO\nOUT\tO\nOF\tO\nCOUNTRY\tO\n.\tO\n\nbut\tO\nnow\tO\ni\tO\nhave\tO\nrealized\tO\nits\tO\na\tO\nproblem\tO\nwith\tO\nthis\tO\nbrand\tB-aspectTerm\n.\tO\n\nI\tO\nsent\tO\nit\tO\nback\tO\nto\tO\nToshiba\tO\ntwice\tO\nthey\tO\ncovered\tO\nit\tO\nunder\tO\nthe\tO\nO\tO\nwarranty\tB-aspectTerm\n.\tO\n\nAlso\tO\nkinda\tO\nloud\tO\nwhen\tO\nthe\tO\nfan\tB-aspectTerm\nwas\tO\nrunning\tO\n.\tO\n\nIn\tO\ndesparation\tO\n,\tO\nI\tO\ncalled\tO\ntheir\tO\nCustomer\tB-aspectTerm\nService\tI-aspectTerm\nnumber\tI-aspectTerm\nand\tO\nwas\tO\ntold\tO\nthat\tO\nmy\tO\nwarranty\tB-aspectTerm\nhad\tO\nexpired\tO\n(\tO\n2\tO\ndays\tO\nold\tO\n)\tO\nand\tO\nthat\tO\nthe\tO\npriviledge\tO\nof\tO\ntalking\tB-aspectTerm\nto\tI-aspectTerm\na\tI-aspectTerm\ntechnician\tI-aspectTerm\nwould\tO\ncost\tO\nme\tO\n(\tO\n\"\tO\nhave\tO\nyour\tO\ncredit\tO\ncard\tO\nready\tO\n\"\tO\n)\tO\n.\tO\n\nThere\tO\nalso\tO\nseemed\tO\nto\tO\nbe\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\nhard\tB-aspectTerm\ndisc\tI-aspectTerm\nas\tO\ncertain\tO\ntimes\tO\nwindows\tB-aspectTerm\nloads\tO\nbut\tO\nclaims\tO\nto\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\nfind\tO\nany\tO\ndrivers\tB-aspectTerm\nor\tO\nfiles\tO\n.\tO\n\nDrivers\tB-aspectTerm\nupdated\tO\nok\tO\nbut\tO\nthe\tO\nBIOS\tB-aspectTerm\nupdate\tI-aspectTerm\nfroze\tO\nthe\tO\nsystem\tB-aspectTerm\nup\tO\nand\tO\nthe\tO\ncomputer\tO\nshut\tO\ndown\tO\n.\tO\n\nSpent\tO\n2\tO\nhours\tO\non\tO\nphone\tO\nwith\tO\nHP\tB-aspectTerm\nTechnical\tI-aspectTerm\nSupport\tI-aspectTerm\n.\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\nis\tO\ntoo\tO\nslick\tO\n.\tO\n\nNightly\tO\nmy\tO\ncomputer\tO\ndefrags\tO\nitself\tO\nand\tO\nruns\tO\na\tO\nvirus\tB-aspectTerm\nscan\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nlike\tO\n9\tB-aspectTerm\npunds\tI-aspectTerm\n,\tO\nbut\tO\nif\tO\nyou\tO\ncan\tO\nlook\tO\npast\tO\nit\tO\n,\tO\nit\tO\n's\tO\nGREAT\tO\n!\tO\n\nIt\tO\n's\tO\njust\tO\nas\tO\nfast\tO\nwith\tO\none\tO\nprogram\tB-aspectTerm\nopen\tO\nas\tO\nit\tO\nis\tO\nwith\tO\nsixteen\tO\nopen\tO\n.\tO\n\nStill\tO\nunder\tO\nwarrenty\tB-aspectTerm\nso\tO\ncalled\tO\nToshiba\tO\n,\tO\nno\tO\nhelp\tO\nat\tO\nall\tO\n.\tO\n\nI\tO\nwas\tO\nhappy\tO\nwith\tO\nMy\tO\npurchase\tO\nof\tO\na\tO\nToshiba\tO\nSatellite\tO\nL305D\tO\n-\tO\nS5934\tO\nlaptop\tO\nuntil\tO\nit\tO\ncame\tO\ntime\tO\nto\tO\nhave\tO\nit\tO\nrepaired\tO\nunder\tO\nthe\tO\nToshiba\tB-aspectTerm\nWarranty\tI-aspectTerm\n.\tO\n\nAmazing\tO\nQuality\tB-aspectTerm\n!\tO\n\nThe\tO\nfact\tO\nthat\tO\nyou\tO\ncan\tO\nspend\tO\nover\tO\n$\tO\n100\tO\non\tO\njust\tO\na\tO\nwebcam\tB-aspectTerm\nunderscores\tO\nthe\tO\nvalue\tB-aspectTerm\nof\tO\nthis\tO\nmachine\tO\n.\tO\n\nI\tO\nmainly\tO\nuse\tO\nit\tO\nfor\tO\nemail\tO\n,\tO\ninternet\tB-aspectTerm\n,\tO\nand\tO\nmanaging\tB-aspectTerm\npersonal\tI-aspectTerm\nfiles\tI-aspectTerm\n(\tO\npics\tO\n,\tO\nvids\tO\n,\tO\netc\tO\n.\tO\n)\tO\n.\tO\n\nA\tO\nmonth\tO\nor\tO\nso\tO\nago\tO\n,\tO\nthe\tO\nfreaking\tO\nmotherboard\tB-aspectTerm\njust\tO\ndied\tO\n.\tO\n\nThe\tO\nsystem\tB-aspectTerm\nit\tO\ncomes\tO\nwith\tO\ndoes\tO\nnot\tO\nwork\tO\nproperly\tO\n,\tO\nso\tO\nwhen\tO\ntrying\tO\nto\tO\nfix\tO\nthe\tO\nproblems\tO\nwith\tO\nit\tO\nit\tO\nstarted\tO\nnot\tO\nworking\tO\nat\tO\nall\tO\n.\tO\n\nThen\tO\nafter\tO\n4\tO\nor\tO\nso\tO\nmonths\tO\nthe\tO\ncharger\tB-aspectTerm\nstopped\tO\nworking\tO\nso\tO\nI\tO\nwas\tO\nforced\tO\nto\tO\ngo\tO\nout\tO\nand\tO\nbuy\tO\nnew\tO\nhardware\tB-aspectTerm\njust\tO\nto\tO\nkeep\tO\nthis\tO\ncomputer\tO\nrunning\tO\n.\tO\n\nIf\tO\na\tO\nwebsite\tO\never\tO\nfreezes\tO\n(\tO\nwhich\tO\nis\tO\nrare\tO\n)\tO\n,\tO\nits\tO\nreally\tO\neasy\tO\nto\tO\nforce\tB-aspectTerm\nquit\tI-aspectTerm\n.\tO\n\nIt\tO\nrarely\tO\nworks\tB-aspectTerm\nand\tO\nwhen\tO\nit\tO\ndoes\tO\nit\tO\n's\tO\nincredibly\tO\nslow\tO\n.\tO\n\nI\tO\nalso\tO\nenjoy\tO\nthe\tO\nfact\tO\nthat\tO\nmy\tO\nMacBook\tO\nPro\tO\nlaptop\tO\nallows\tO\nme\tO\nto\tO\nrun\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\non\tO\nit\tO\nby\tO\nusing\tO\nthe\tO\nVMWare\tB-aspectTerm\nprogram\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tO\nto\tO\nnavigate\tB-aspectTerm\nthrough\tO\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n,\tO\nto\tO\nfind\tB-aspectTerm\nfiles\tI-aspectTerm\n,\tO\nand\tO\nit\tO\nruns\tB-aspectTerm\na\tO\nlot\tO\nfaster\tO\n!\tO\n\nPurchased\tO\na\tO\nToshiba\tO\nLap\tO\ntop\tO\nit\tO\nworked\tO\ngood\tO\nuntil\tO\njust\tO\nafter\tO\nthe\tO\nwarrenty\tB-aspectTerm\nwent\tO\nout\tO\n.\tO\n\nI\tO\nwanted\tO\nto\tO\npurchase\tO\nthe\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\nand\tO\nthey\tO\nrefused\tO\n,\tO\nbecause\tO\nthey\tO\nknew\tO\nit\tO\nwas\tO\ntrouble\tO\n.\tO\n\nWe\tO\nupgraded\tO\nthe\tO\nmemory\tB-aspectTerm\nto\tO\nfour\tO\ngigabytes\tO\nin\tO\norder\tO\nto\tO\ntake\tO\nadvantage\tO\nof\tO\nthe\tO\nperformace\tB-aspectTerm\nincrease\tO\nin\tO\nspeed\tB-aspectTerm\n.\tO\n\nThe\tO\nreality\tO\nwas\tO\n,\tO\nit\tO\nheated\tO\nup\tO\nvery\tO\nquickly\tO\n,\tO\nand\tO\ntook\tO\nway\tO\ntoo\tO\nlong\tO\nto\tO\ndo\tO\nsimple\tO\nthings\tO\n,\tO\nlike\tO\nopening\tB-aspectTerm\nmy\tI-aspectTerm\nDocuments\tI-aspectTerm\nfolder\tI-aspectTerm\n.\tO\n\nI\tO\nhad\tO\nalways\tO\nused\tO\nPCs\tO\nand\tO\nbeen\tO\nconstantly\tO\nfrustrated\tO\nby\tO\nthe\tO\ncrashing\tO\nand\tO\nthe\tO\npoorly\tO\ndesigned\tO\noperating\tB-aspectTerm\nsystems\tI-aspectTerm\nthat\tO\nwere\tO\nnever\tO\nvery\tO\nintuitive\tO\n.\tO\n\nThen\tO\n,\tO\nwithin\tO\n5\tO\nmonths\tO\n,\tO\nthe\tO\ncharger\tB-aspectTerm\ncrapped\tO\nout\tO\non\tO\nme\tO\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\nhave\tO\na\tO\niphone\tO\nor\tO\nipod\tO\ntouch\tO\nyou\tO\ncan\tO\nconnect\tO\nand\tO\ndownload\tO\nsongs\tO\nto\tO\nit\tO\nat\tO\nhigh\tO\nspeed\tB-aspectTerm\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nglass\tB-aspectTerm\ntouchpad\tI-aspectTerm\n.\tO\n\nÂ\tO\nI\tO\ncontinued\tO\nto\tO\ntake\tO\nthe\tO\ncomputer\tO\nin\tO\nAGAIN\tO\nand\tO\nthey\tO\nreplaced\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nmother\tB-aspectTerm\nboard\tI-aspectTerm\nyet\tO\nagain\tO\n.\tO\n\nI\tO\nam\tO\nusing\tO\nthe\tO\nexternal\tB-aspectTerm\nspeaker-\tI-aspectTerm\nsound\tB-aspectTerm\nis\tO\ngood\tO\n.\tO\n\nstill\tO\ntesting\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nas\tO\ni\tO\nthought\tO\nit\tO\nwould\tO\nbe\tO\nbetter\tO\n,\tO\nbut\tO\nam\tO\nvery\tO\nhappy\tO\nwith\tO\nthe\tO\nupgrade\tO\n.\tO\n\nThen\tO\nHP\tO\nsends\tO\nit\tO\nback\tO\nto\tO\nme\tO\nwith\tO\nthe\tO\nhardware\tB-aspectTerm\nscrewed\tO\nup\tO\n,\tO\nnot\tO\nable\tO\nto\tO\nconnect\tO\n.\tO\n\nOh\tO\nyeah\tO\n,\tO\ndo\tO\nn't\tO\nforget\tO\nthe\tO\nexpensive\tO\nshipping\tB-aspectTerm\nto\tO\nand\tO\nfrom\tO\nHP\tO\n.\tO\n\nEverything\tO\nis\tO\nso\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nMac\tB-aspectTerm\nsoftware\tI-aspectTerm\nis\tO\njust\tO\nso\tO\nmuch\tO\nsimpler\tO\nthan\tO\nMicrosoft\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\ndo\tO\na\tO\nlot\tO\nof\tO\nwriting\tO\n,\tO\nediting\tB-aspectTerm\nis\tO\na\tO\nproblem\tO\nsince\tO\nthere\tO\nis\tO\nno\tO\nO\tO\nforward\tO\ndelete\tB-aspectTerm\nI-aspectTerm\tI-aspectTerm\nkey\tI-aspectTerm\n.\tO\n\nIts\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\nand\tO\nthe\tO\ntop\tO\nservice\tB-aspectTerm\nfrom\tO\nApple-\tO\nbe\tO\nit\tO\ntheir\tO\nphone\tB-aspectTerm\nassistance\tI-aspectTerm\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tB-aspectTerm\nbar-\tI-aspectTerm\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\nand\tO\nword\tB-aspectTerm\nediting\tI-aspectTerm\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tB-aspectTerm\nand\tO\nmovie\tB-aspectTerm\nplaying\tI-aspectTerm\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nAcer\tO\nhas\tO\nset\tO\nme\tO\nup\tO\nwith\tO\nFREE\tO\nrecovery\tB-aspectTerm\ndiscs\tI-aspectTerm\n,\tO\nwhen\tO\nthey\tO\nare\tO\navailable\tO\nsince\tO\nI\tO\nasked\tO\n.\tO\n\nI\tO\nalso\tO\npurchased\tO\nOffice\tB-aspectTerm\nMax\tI-aspectTerm\n's\tI-aspectTerm\n\"\tI-aspectTerm\nMax\tI-aspectTerm\nAssurance\tI-aspectTerm\n\"\tI-aspectTerm\nwith\tO\nthe\tO\n\"\tO\nno\tO\nlemon\tO\n\"\tO\nclause\tO\n.\tO\n\nI\tO\neventually\tO\ndid\tO\nthe\tO\nmigration\tO\nfrom\tO\nmy\tO\niMac\tB-aspectTerm\nbackup\tI-aspectTerm\ndisc\tI-aspectTerm\nwhich\tO\nuses\tO\nUSB\tB-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nseems\tO\nto\tO\nbe\tO\nvery\tO\ngood\tO\n,\tO\nand\tO\nhave\tO\nhad\tO\nno\tO\nissues\tO\nwith\tO\nit\tO\n.\tO\n\nEnabling\tO\nthe\tO\nbattery\tB-aspectTerm\ntimer\tI-aspectTerm\nis\tO\nuseless\tO\n.\tO\n\nTemperatures\tB-aspectTerm\non\tO\nthe\tO\noutside\tO\nwere\tO\nalright\tO\nbut\tO\ni\tO\ndid\tO\nnot\tO\ntrack\tO\nin\tO\nCore\tB-aspectTerm\nProcessing\tI-aspectTerm\nUnit\tI-aspectTerm\ntemperatures\tI-aspectTerm\n.\tO\n\nGoing\tO\nto\tO\nbring\tO\nit\tO\nto\tO\nservice\tB-aspectTerm\ntoday\tO\n.\tO\n\nThere\tO\nis\tO\nno\tO\nneed\tO\nto\tO\npurchase\tO\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\nfor\tI-aspectTerm\nMac\tI-aspectTerm\n,\tO\nwhich\tO\nsaves\tO\nme\tO\na\tO\nlot\tO\nof\tO\ntime\tO\nand\tO\nmoney\tO\n.\tO\n\nBut\tO\nwe\tO\nhad\tO\npaid\tO\nfor\tO\nbluetooth\tB-aspectTerm\n,\tO\nand\tO\nthere\tO\nwas\tO\nnone\tO\n.\tO\n\nSo\tO\n,\tO\nI\tO\npaid\tO\na\tO\nvisit\tO\nto\tO\nLG\tB-aspectTerm\nnotebook\tI-aspectTerm\nservice\tI-aspectTerm\ncenter\tI-aspectTerm\nat\tO\nAlexandra\tO\nRoad\tO\n,\tO\nhoping\tO\nthey\tO\ncan\tO\nmake\tO\nthe\tO\nhinge\tB-aspectTerm\ntighter\tO\n.\tO\n\nIt\tO\nis\tO\nalways\tO\nreliable\tO\n,\tO\nnever\tO\nbugged\tO\nand\tO\nresponds\tB-aspectTerm\nwell\tO\n.\tO\n\nAfter\tO\nabout\tO\na\tO\nweek\tO\nI\tO\nfinally\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nthe\tO\nmotherboard\tB-aspectTerm\nhad\tO\nfailed\tO\nand\tO\nso\tO\nthey\tO\ninstalled\tO\na\tO\nnew\tO\nmotherboard\tB-aspectTerm\n.\tO\n\nthey\tO\nhad\tO\nto\tO\nreplace\tO\nthe\tO\nmotherboard\tB-aspectTerm\nin\tO\nApril\tO\n\nYes\tO\n,\tO\nthe\tO\ncomputer\tO\nwas\tO\nlight\tO\nweight\tO\n,\tO\nless\tO\nexpensive\tO\nthan\tO\nthe\tO\naverage\tO\nlaptop\tO\n,\tO\nand\tO\nwas\tO\npretty\tO\nself\tO\nexplantory\tO\nin\tO\nuse\tB-aspectTerm\n.\tO\n\nAlso\tO\n,\tO\nif\tO\nyou\tO\nneed\tO\nto\tO\ntalk\tO\nto\tO\na\tO\nrepresentive\tB-aspectTerm\nat\tI-aspectTerm\nMicrosoft\tI-aspectTerm\n,\tO\nthere\tO\nis\tO\na\tO\ncharge\tO\n,\tO\nwhich\tO\nI\tO\nbelieve\tO\nis\tO\nrobbery\tO\n,\tO\nsince\tO\nyou\tO\nare\tO\ncharged\tO\nenormous\tO\namounts\tO\nfor\tO\na\tO\nvery\tO\nbadly\tO\ndesigned\tO\nsystem\tB-aspectTerm\n,\tO\nwhich\tO\nmost\tO\npeople\tO\nwould\tO\nhave\tO\nwent\tO\nwith\tO\nXP\tB-aspectTerm\nif\tO\nthey\tO\ncould\tO\n.\tO\n\nI\tO\nlove\tO\nWIndows\tB-aspectTerm\n7\tI-aspectTerm\nwhich\tO\nis\tO\na\tO\nvast\tO\nimprovment\tO\nover\tO\nVista\tB-aspectTerm\n.\tO\n\nKeyboard\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nvery\tO\nquiet\tO\nfor\tO\nall\tO\nthe\tO\ntyping\tO\nthat\tO\nI\tO\ndo\tO\n.\tO\n\nDell\tB-aspectTerm\n's\tI-aspectTerm\ncustomer\tI-aspectTerm\ndisservice\tI-aspectTerm\nis\tO\nan\tO\ninsult\tO\nto\tO\nit\tO\n's\tO\ncustomers\tO\nwho\tO\npay\tO\ngood\tO\nmoney\tO\nfor\tO\nshoddy\tO\nproducts\tO\n.\tO\n\nIt\tO\nhad\tO\na\tO\ncooling\tO\nsystem\tO\nmalfunction\tO\nafter\tO\n10\tO\nminutes\tO\nof\tO\ngeneral\tO\nuse\tB-aspectTerm\n,\tO\nand\tO\nwould\tO\nnot\tO\nmove\tO\npast\tO\nthis\tO\nerror\tO\n.\tO\n\nI\tO\ncan\tO\nrender\tO\nAVCHD\tO\nmovies\tO\nwith\tO\nlittle\tO\neffort\tO\n,\tO\nwhich\tO\nwas\tO\na\tO\nproblem\tO\nfor\tO\nmost\tO\npc\tO\n's\tO\nunless\tO\nyou\tO\nhad\tO\na\tO\nquad\tB-aspectTerm\ncore\tI-aspectTerm\nI7\tI-aspectTerm\n.\tO\n\nAfter\tO\ntalking\tO\nit\tO\nover\tO\nwith\tO\nthe\tO\nvery\tO\nknowledgeable\tO\nsales\tB-aspectTerm\nassociate\tI-aspectTerm\n,\tO\nI\tO\nchose\tO\nthe\tO\nMacBook\tO\nPro\tO\nover\tO\nthe\tO\nwhite\tO\nMacBook\tO\n.\tO\n\nIf\tO\nyou\tO\nreally\tO\nwant\tO\na\tO\nbang\tO\n-\tO\nup\tO\nsystem\tB-aspectTerm\nand\tO\ndo\tO\nn't\tO\nneed\tO\nto\tO\nrun\tO\nWindows\tB-aspectTerm\napplications\tI-aspectTerm\n,\tO\ngo\tO\nwith\tO\nan\tO\nApple\tO\n;\tO\n\nYou\tO\nwo\tO\nn't\tO\nhave\tO\nto\tO\nspend\tO\ngobs\tO\nof\tO\nmoney\tO\non\tO\nsome\tO\ninefficient\tO\nvirus\tB-aspectTerm\nprogram\tI-aspectTerm\nthat\tO\nneeds\tO\nto\tO\nbe\tO\nupdated\tO\nevery\tO\nmonth\tO\nand\tO\nthat\tO\nconstantly\tO\ndrains\tO\nyour\tO\nwallet\tO\n.\tO\n\nIt\tO\nweighed\tB-aspectTerm\nlike\tO\nseven\tB-aspectTerm\npounds\tI-aspectTerm\nor\tO\nsomething\tO\nlike\tO\nthat\tO\n.\tO\n\nYou\tO\nmay\tO\nneed\tO\nto\tO\nspecial\tO\norder\tO\na\tO\nbag\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\ncolor\tB-aspectTerm\nis\tO\neven\tO\ncool\tO\n.\tO\n\nkeys\tB-aspectTerm\nare\tO\nall\tO\nin\tO\nweird\tO\nplaces\tO\nand\tO\nis\tO\nway\tO\ntoo\tO\nlarge\tO\nfor\tO\nthe\tO\nway\tO\nit\tO\nis\tO\ndesigned\tB-aspectTerm\n.\tO\n\nYes\tO\n,\tO\na\tO\nMac\tO\nis\tO\nmuch\tO\nmore\tO\nmoney\tO\nthan\tO\nthe\tO\naverage\tO\nlaptop\tO\nout\tO\nthere\tO\n,\tO\nbut\tO\nthere\tO\nis\tO\nno\tO\ncomparison\tO\nin\tO\nstyle\tB-aspectTerm\n,\tO\nspeed\tB-aspectTerm\nand\tO\njust\tO\ncool\tO\nfactor\tO\n.\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\nfeels\tO\ngood\tO\nand\tO\nI\tO\ntype\tO\njust\tO\nfine\tO\non\tO\nit\tO\n.\tO\n\nI\tO\nthought\tO\nthe\tO\nwhite\tO\nMac\tO\ncomputers\tO\nlooked\tO\ndirty\tO\ntoo\tO\nquicly\tO\nwhere\tO\nyou\tO\nuse\tO\nthe\tO\nmousepad\tB-aspectTerm\nand\tO\nwhere\tO\nyou\tO\nplace\tO\nyour\tO\nhands\tO\nwhen\tO\ntyping\tO\n.\tO\n\nAnd\tO\nnot\tO\nto\tO\nmention\tO\nafter\tO\nusing\tO\nit\tO\nfor\tO\na\tO\nfew\tO\nmonths\tO\nor\tO\nso\tO\n,\tO\nthe\tO\nbattery\tB-aspectTerm\nwill\tO\nslowly\tO\nless\tO\nand\tO\nless\tO\nhold\tO\na\tO\ncharge\tO\nuntil\tO\nyou\tO\nca\tO\nn't\tO\nleave\tO\nit\tO\nunplugged\tO\nfor\tO\nmore\tO\nthan\tO\n5\tO\nminutes\tO\nwithout\tO\nthe\tO\nthing\tO\ndying\tO\n.\tO\n\nBEST\tO\nBUY\tO\n-\tO\n5\tO\nSTARS\tO\n+\tO\n+\tO\n+\tO\n(\tO\nsales\tB-aspectTerm\n,\tO\nservice\tB-aspectTerm\n,\tO\nrespect\tO\nfor\tO\nold\tO\nmen\tO\nwho\tO\nare\tO\nn't\tO\nfamiliar\tO\nwith\tO\nthe\tO\ntechnology\tO\n)\tO\nDELL\tO\nCOMPUTERS\tO\n-\tO\n3\tO\nstars\tO\nDELL\tB-aspectTerm\nSUPPORT\tI-aspectTerm\n-\tO\nowes\tO\na\tO\nme\tO\na\tO\ncouple\tO\n\nno\tO\ncomplaints\tO\nwith\tO\ntheir\tO\ndesktop\tO\n,\tO\nand\tO\nmaybe\tO\nbecause\tO\nit\tO\njust\tO\nsits\tO\non\tO\nyour\tO\ndesktop\tO\n,\tO\nand\tO\nyou\tO\ndo\tO\nn't\tO\ncarry\tO\nit\tO\naround\tO\n,\tO\nwhich\tO\ncould\tO\njar\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n,\tO\nor\tO\nthe\tO\nmotherboard\tB-aspectTerm\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tB-aspectTerm\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tO\nup\tO\nfor\tO\nit\tO\nin\tO\nspeed\tB-aspectTerm\n,\tO\nconstruction\tB-aspectTerm\nquality\tI-aspectTerm\n,\tO\nand\tO\nlongevity\tB-aspectTerm\n.\tO\n\nSince\tO\nI\tO\nkeyboard\tO\nover\tO\n100\tO\nwpm\tO\n,\tO\nI\tO\nlook\tO\nfor\tO\na\tO\nunit\tO\nthat\tO\nhas\tO\na\tO\ncomfortble\tO\nkeyboard\tB-aspectTerm\n(\tO\nno\tO\nkeys\tB-aspectTerm\nsticking\tO\nor\tO\nlagging\tO\n,\tO\nstrange\tO\nconfiguration\tB-aspectTerm\nof\tI-aspectTerm\n\"\tI-aspectTerm\nextra\tI-aspectTerm\nkey\tI-aspectTerm\n\"\tI-aspectTerm\n,\tO\netc\tO\n.\tO\n\n)\tO\nI\tO\nalso\tO\ntried\tO\nthe\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\nand\tO\ncompared\tO\nit\tO\nto\tO\nother\tO\nnetbooks\tO\nin\tO\nthe\tO\nstore\tO\n.\tO\n\nIt\tO\nabsolutely\tO\nis\tO\nmore\tO\nexpensive\tO\nthan\tO\nmost\tO\nPC\tO\nlaptops\tO\n,\tO\nbut\tO\nthe\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\n,\tO\nsecurity\tB-aspectTerm\n,\tO\nand\tO\nminimal\tO\nproblems\tO\nthat\tO\nhave\tO\narisen\tO\nmake\tO\nit\tO\nwell\tO\nworth\tO\nthe\tO\npricetag\tB-aspectTerm\n.\tO\n\nÂ\tO\nIt\tO\ngets\tO\nstuck\tO\nall\tO\nof\tO\nthe\tO\ntime\tO\nyou\tO\nuse\tB-aspectTerm\nit\tO\n,\tO\nand\tO\nyou\tO\nhave\tO\nto\tO\nkeep\tO\ntapping\tO\non\tO\nit\tO\nto\tO\nget\tO\nit\tO\nto\tO\nwork\tB-aspectTerm\n.\tO\n\nlots\tO\nof\tO\npreloaded\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nI\tO\nwish\tO\nit\tO\nhad\tO\na\tO\nwebcam\tB-aspectTerm\nthough\tO\n,\tO\nthen\tO\nit\tO\nwould\tO\nbe\tO\nperfect\tO\n!\tO\n\nMy\tO\nfavorite\tO\npart\tO\nof\tO\nthis\tO\ncomputer\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\na\tO\nvga\tB-aspectTerm\nport\tI-aspectTerm\nso\tO\nI\tO\ncan\tO\nconnect\tO\nit\tO\nto\tO\na\tO\nbigger\tO\nscreen\tB-aspectTerm\n.\tO\n\nAnother\tO\nthing\tO\nI\tO\nmight\tO\nadd\tO\nis\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nexcellent\tO\n.\tO\n\nOne\tO\ndrawback\tO\n,\tO\nI\tO\nwish\tO\nthe\tO\nkeys\tB-aspectTerm\nwere\tO\nbacklit\tO\n.\tO\n\nAcer\tO\nwas\tO\nno\tO\nhelp\tO\nand\tO\nGarmin\tO\ncould\tO\nnot\tO\ndetermine\tO\nthe\tO\nproblem(after\tO\nspending\tO\nabout\tO\n2\tO\nhours\tO\nwith\tO\nme\tO\n)\tO\n,\tO\nso\tO\nI\tO\nreturned\tO\nit\tO\nand\tO\npurchased\tO\na\tO\nToshiba\tO\nR700\tO\nthat\tO\nseems\tO\neven\tO\nnicer\tO\nand\tO\nI\tO\nwas\tO\nable\tO\nto\tO\nload\tO\nall\tO\nof\tO\nmy\tO\nsoftware\tB-aspectTerm\nwith\tO\nno\tO\nproblem\tO\n.\tO\n\nI\tO\nwish\tO\nthe\tO\nvolume\tB-aspectTerm\ncould\tO\nbe\tO\nlouder\tO\nand\tO\nthe\tO\nmouse\tB-aspectTerm\ndid\tO\nnt\tO\nbreak\tO\nafter\tO\nonly\tO\na\tO\nmonth\tO\n.\tO\n\nI\tO\nplay\tO\na\tO\nlot\tO\nof\tO\ncasual\tO\ngames\tO\nonline\tO\n,\tO\nand\tO\nthe\tO\ntouchpad\tB-aspectTerm\nis\tO\nvery\tO\nresponsive\tO\n.\tO\n\nGranted\tO\n,\tO\nit\tO\n's\tO\nstill\tO\na\tO\nvery\tO\nnew\tO\nlaptop\tO\nbut\tO\nin\tO\ncomparison\tO\nto\tO\nmy\tO\nprevious\tO\nlaptops\tO\nand\tO\ndesktops\tO\n,\tO\nmy\tO\nMac\tO\nboots\tB-aspectTerm\nup\tI-aspectTerm\nnoticeably\tO\nquicker\tO\n.\tO\n\nIt\tO\ncaught\tO\na\tO\nvirus\tO\nthat\tO\ncompletely\tO\nwiped\tO\nout\tO\nmy\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nin\tO\na\tO\nmatter\tO\nof\tO\nhours\tO\n.\tO\n\nIt\tO\nis\tO\neverything\tO\nI\tO\n'd\tO\nhoped\tO\nit\tO\nwould\tO\nbe\tO\nfrom\tO\na\tO\nlook\tB-aspectTerm\nand\tI-aspectTerm\nfeel\tI-aspectTerm\nstandpoint\tI-aspectTerm\n,\tO\nbut\tO\nsomehow\tO\na\tO\nbit\tO\nmore\tO\nsturdy\tO\n.\tO\n\nthe\tO\nonly\tO\nfact\tO\ni\tO\ndo\tO\nnt\tO\nlike\tO\nabout\tO\napples\tO\nis\tO\nthey\tO\ngenerally\tO\nuse\tO\nsafari\tB-aspectTerm\nand\tO\ni\tO\ndo\tO\nnt\tO\nuse\tO\nsafari\tB-aspectTerm\nbut\tO\nafter\tO\ni\tO\ninstall\tO\nMozzilla\tB-aspectTerm\nfirfox\tI-aspectTerm\ni\tO\nlove\tO\nevery\tO\nsingle\tO\nbit\tO\nabout\tO\nit\tO\n.\tO\n\nThe\tO\nBluetooth\tB-aspectTerm\nwas\tO\nnot\tO\nthere\tO\nat\tO\nall\tO\n,\tO\nand\tO\nthe\tO\nfingerprint\tB-aspectTerm\nreader\tI-aspectTerm\ndriver\tI-aspectTerm\nwould\tO\nbe\tO\nthere\tO\n,\tO\nbut\tO\nthe\tO\nsoftware\tB-aspectTerm\nwould\tO\nhang\tO\nafter\tO\ninstallation\tO\nwas\tO\n1/2\tO\nway\tO\ndone\tO\n.\tO\n\nGreat\tO\nbattery\tO\n,\tO\nspeed\tB-aspectTerm\n,\tO\ndisplay\tB-aspectTerm\n.\tO\n\nThe\tO\ndelivery\tB-aspectTerm\nwas\tO\nfast\tO\n,\tO\nand\tO\nI\tO\nwould\tO\nnot\tO\nhesitate\tO\nto\tO\npurchase\tO\nthis\tO\nlaptop\tO\nagain\tO\n.\tO\n\nI\tO\n've\tO\nbeen\tO\nimpressed\tO\nwith\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nand\tO\nthe\tO\nperformance\tB-aspectTerm\nfor\tO\nsuch\tO\na\tO\nsmall\tO\namount\tO\nof\tO\nmemory\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\napplications\tB-aspectTerm\nare\tO\nterrific\tO\n,\tO\nincluding\tO\nthe\tO\nreplacements\tO\nfor\tO\nMicrosoft\tB-aspectTerm\noffice\tI-aspectTerm\n.\tO\n\nthey\tO\nimproved\tO\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tB-aspectTerm\n,\tO\nappearance\tB-aspectTerm\n,\tO\ncooling\tB-aspectTerm\nsystem\tI-aspectTerm\n,\tO\ngraphics\tB-aspectTerm\ncard\tI-aspectTerm\n,\tO\netc\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nwebcam\tI-aspectTerm\nand\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nmic\tI-aspectTerm\nwere\tO\nshorting\tO\nout\tO\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tO\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tO\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tB-aspectTerm\nand\tO\nmic\tB-aspectTerm\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nMy\tO\ndad\tO\nhas\tO\none\tO\nof\tO\nthe\tO\nvery\tO\nfirst\tO\nToshibas\tO\never\tO\nmade\tO\n,\tO\nyes\tO\nits\tO\nabit\tO\nslow\tO\nnow\tO\nbut\tO\nstill\tO\nworks\tO\nwell\tO\nand\tO\ni\tO\nhooked\tO\nto\tO\nmy\tO\nethernet\tB-aspectTerm\n!\tO\n\nMostly\tO\nI\tO\nlove\tO\nthe\tO\ndrag\tB-aspectTerm\nand\tI-aspectTerm\ndrop\tI-aspectTerm\nfeature\tI-aspectTerm\n.\tO\n\noh\tO\nyeah\tO\n,\tO\nand\tO\nif\tO\nthe\tO\nfancy\tO\nwebcam\tB-aspectTerm\nbreaks\tO\nguess\tO\nwho\tO\nyou\tO\nhave\tO\nto\tO\nsend\tO\nit\tO\nto\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\n?\tO\n\nI\tO\nordered\tO\nthrough\tO\nMacMall\tO\n,\tO\nwhich\tO\nsaved\tO\nme\tO\nthe\tO\nsales\tB-aspectTerm\ntax\tI-aspectTerm\nI\tO\nwould\tO\nhave\tO\nincurred\tO\nbuying\tO\nlocally\tO\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tO\nsoftware\tB-aspectTerm\npackages\tI-aspectTerm\nthat\tO\ncame\tO\nfor\tO\nfree\tO\nincluding\tO\niWork\tB-aspectTerm\n,\tO\nGarageBand\tB-aspectTerm\n,\tO\nand\tO\niMovie\tB-aspectTerm\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nvery\tO\nlarge\tO\nand\tO\ncrystal\tO\nclear\tO\nwith\tO\namazing\tO\ncolors\tO\nand\tO\nresolution\tB-aspectTerm\n.\tO\n\nAfter\tO\na\tO\nlittle\tO\nmore\tO\nthan\tO\na\tO\nyear\tO\nof\tO\nowning\tO\nmy\tO\nMacBook\tO\nPro\tO\n,\tO\nthe\tO\nmonitor\tB-aspectTerm\nhas\tO\ncompletely\tO\ndied\tO\n.\tO\n\nThe\tO\nbrand\tO\nof\tO\niTunes\tB-aspectTerm\nhas\tO\njust\tO\nbecome\tO\ningrained\tO\nin\tO\nour\tO\nlexicon\tO\nnow\tO\n,\tO\nbut\tO\nkeep\tO\nin\tO\nmind\tO\nthat\tO\nApple\tO\nstarted\tO\nit\tO\nall\tO\n.\tO\n\nSize\tB-aspectTerm\n:\tO\nI\tO\nknow\tO\n13\tO\nis\tO\nsmall\tO\n(\tO\nespecially\tO\nfor\tO\na\tO\ndesktop\tO\nreplacement\tO\n)\tO\nbut\tO\nwith\tO\nan\tO\nexternal\tB-aspectTerm\nmonitor\tI-aspectTerm\n,\tO\nwho\tO\ncares\tO\n.\tO\n\nAdditional\tO\ncaveat\tO\n:\tO\nthe\tO\nbase\tB-aspectTerm\ninstallation\tI-aspectTerm\ncomes\tO\nwith\tO\nsome\tO\nToshiba\tO\n-\tO\nspecific\tO\nsoftware\tB-aspectTerm\nthat\tO\nmay\tO\nor\tO\nmay\tO\nnot\tO\nbe\tO\nto\tO\na\tO\nuser\tO\n's\tO\nliking\tO\n.\tO\n\nÂ\tO\nTaking\tO\nit\tO\nback\tO\nto\tO\nBest\tO\nBuy\tO\nI\tO\nfound\tO\nthat\tO\na\tO\ntiny\tO\nplastic\tO\npiece\tO\ninside\tO\nhad\tO\nbroken\tO\n(\tO\nmanuf\tB-aspectTerm\nissue\tO\n)\tO\n.\tO\n\nThe\tO\ndisplay\tB-aspectTerm\nis\tO\nincredibly\tO\nbright\tO\n,\tO\nmuch\tO\nbrighter\tO\nthan\tO\nmy\tO\nPowerBook\tO\nand\tO\nvery\tO\ncrisp\tO\n.\tO\n\nThe\tO\nAMD\tB-aspectTerm\nTurin\tI-aspectTerm\nprocessor\tI-aspectTerm\nseems\tO\nto\tO\nalways\tO\nperform\tO\nso\tO\nmuch\tO\nbetter\tO\nthan\tO\nIntel\tB-aspectTerm\n.\tO\n\nÂ\tO\nAfter\tO\nthat\tO\nthe\tO\nsaid\tO\nit\tO\nwas\tO\nunder\tO\nwarranty\tB-aspectTerm\n.\tO\n\nThe\tO\nstart\tB-aspectTerm\nmenu\tI-aspectTerm\nis\tO\nnot\tO\nthe\tO\neasiest\tO\nthing\tO\nto\tO\nnavigate\tB-aspectTerm\ndue\tO\nto\tO\nthe\tO\nstacking\tO\n.\tO\n\nThe\tO\nservice\tB-aspectTerm\ntech\tI-aspectTerm\nsaid\tO\nhe\tO\nhad\tO\ntried\tO\nto\tO\nduplicate\tO\nthe\tO\ndamage\tO\nand\tO\nwas\tO\nn't\tO\nable\tO\nto\tO\nrecreate\tO\nit\tO\ntherefore\tO\nit\tO\nhad\tO\nto\tO\nbe\tO\ntheir\tO\ndefect\tO\n.\tO\n\nThe\tO\ntech\tB-aspectTerm\nstore\tI-aspectTerm\nI\tO\npurchased\tO\nthis\tO\nfrom\tO\nsent\tO\nit\tO\nback,,,,,eventually\tO\nI\tO\ngot\tO\na\tO\nnew\tO\nor\tO\nrepaired\tO\nmachine\tO\napproximately\tO\n3\tO\nweeks\tO\nlater\tO\n.\tO\n\nReally\tO\nlike\tO\nthe\tO\ntextured\tO\nsurface\tB-aspectTerm\nwhich\tO\nshows\tO\nno\tO\nfingerprints\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nbright\tO\nand\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\nnice\tO\n;\tO\n\nBut\tO\nthe\tO\nmachine\tO\nis\tO\nawesome\tO\nand\tO\niLife\tB-aspectTerm\nis\tO\ngreat\tO\nand\tO\nI\tO\nlove\tO\nSnow\tB-aspectTerm\nLeopard\tI-aspectTerm\nX.\tI-aspectTerm\n\nHigh\tO\nprice\tB-aspectTerm\ntag\tI-aspectTerm\n,\tO\nhowever\tO\n.\tO\n\nI\tO\nthought\tO\nlearning\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nwould\tO\nbe\tO\nhard\tO\n,\tO\nbut\tO\nit\tO\nis\tO\neasily\tO\npicked\tO\nup\tO\nif\tO\nyou\tO\nare\tO\nfamiliar\tO\nwith\tO\na\tO\nPC\tO\n.\tO\n\nI\tO\nhad\tO\nstatic\tO\nin\tO\nthe\tO\noutput\tO\n,\tO\nand\tO\nI\tO\nhad\tO\nto\tO\nreduce\tO\nthe\tO\nsound\tB-aspectTerm\noutput\tI-aspectTerm\nquality\tI-aspectTerm\nto\tO\n\"\tO\nFM\tO\n\"\tO\nas\tO\nopposed\tO\nto\tO\nthe\tO\ndefault\tO\n\"\tO\nCD\tO\n.\tO\n\nI\tO\ncustom\tO\nordered\tO\nthe\tO\nmachine\tO\nfrom\tO\nHP\tO\nand\tO\ncould\tO\nNOT\tO\nunderstand\tO\nthe\tO\ntechie\tB-aspectTerm\ndue\tO\nto\tO\nhis\tO\naccent\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nlightweight\tO\n.\tO\n\nI\tO\nwent\tO\nto\tO\nToshiba\tB-aspectTerm\nonline\tI-aspectTerm\nhelp\tI-aspectTerm\nand\tO\nfound\tO\nsome\tO\nsuggestions\tO\nto\tO\nfix\tO\nit\tO\n.\tO\n\nThey\tO\nalso\tO\nhave\tO\na\tO\nlonger\tO\nservice\tB-aspectTerm\nlife\tI-aspectTerm\nthan\tO\nother\tO\ncomputers\tO\n(\tO\nI\tO\nhave\tO\nseveral\tO\nfriends\tO\nwho\tO\nstill\tO\nuse\tO\nthe\tO\nolder\tO\nApple\tO\nPowerBooks\tO\n)\tO\n.\tO\n\nIf\tO\nyou\tO\ncheck\tO\nyou\tO\nwill\tO\nfind\tO\nthe\tO\nsame\tO\nnotebook\tO\nwith\tO\nthe\tO\nabove\tO\nmissing\tO\nports\tB-aspectTerm\nand\tO\na\tO\ndual\tO\ncore\tO\nAMD\tO\nor\tO\nIntel\tO\nprocessor\tB-aspectTerm\n.\tO\n\nThis\tO\nlaptop\tO\nis\tO\na\tO\ngreat\tO\nprice\tB-aspectTerm\nand\tO\nhas\tO\na\tO\nsleek\tO\nlook\tB-aspectTerm\n.\tO\n\nI\tO\nespecially\tO\nlike\tO\nthe\tO\nkeyboard\tB-aspectTerm\nwhich\tO\nhas\tO\nchiclet\tO\ntype\tO\nkeys\tB-aspectTerm\n.\tO\n\nSmall\tO\nscreen\tB-aspectTerm\nsomewhat\tO\nlimiting\tO\nbut\tO\ngreat\tO\nfor\tO\ntravel\tO\n.\tO\n\nRuns\tO\nHot\tO\nO\tO\nI\tO\nthought\tO\nwe\tO\nwere\tO\npaying\tO\nfor\tO\nquality\tB-aspectTerm\nin\tO\nour\tO\ndecision\tO\nto\tO\nbuy\tO\nan\tO\nApple\tO\nproduct\tO\n.\tO\n\nFor\tO\nthe\tO\nnot\tO\nso\tO\ngood\tO\n,\tO\nI\tO\ngot\tO\nthe\tO\nstock\tB-aspectTerm\nscreen\tI-aspectTerm\n-\tO\nwhich\tO\nis\tO\nVERY\tO\nglossy\tO\n.\tO\n\nThe\tO\ngray\tB-aspectTerm\ncolor\tI-aspectTerm\nwas\tO\na\tO\ngood\tO\nchoice\tO\n.\tO\n\nI\tO\nwould\tO\nlike\tO\nto\tO\nhave\tO\nvolume\tB-aspectTerm\nbuttons\tI-aspectTerm\nrather\tO\nthan\tO\nthe\tO\nadjustment\tO\nthat\tO\nis\tO\non\tO\nthe\tO\nfront\tO\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\na\tO\nAMD\tO\nSemprom\tO\nat\tO\n2.1\tO\nghz\tO\nis\tO\na\tO\nbummer\tO\nit\tO\ndoes\tO\nnot\tO\nhave\tO\nthe\tO\npower\tO\nfor\tO\nHD\tO\nor\tO\nheavy\tO\ncomputing\tB-aspectTerm\n.\tO\n\nI\tO\nbought\tO\na\tO\nprotector\tB-aspectTerm\nfor\tO\nmy\tO\nkey\tB-aspectTerm\npad\tI-aspectTerm\nand\tO\nit\tO\nworks\tO\ngreat\tO\n:)\tO\n\nIt\tO\nseems\tO\nthey\tO\ncould\tO\nhave\tO\nupdated\tO\nXP\tB-aspectTerm\nand\tO\ndone\tO\nwithout\tO\ncreating\tO\nVista\tB-aspectTerm\n.\tO\n\nÂ\tO\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nfast\tO\nand\tO\nhas\tO\ngreat\tO\ngraphics\tB-aspectTerm\nfor\tO\nthe\tO\nmoney\tO\n.\tO\n\nI\tO\nlike\tO\nhow\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nis\tO\nso\tO\nsimple\tO\nand\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n.\tO\n\nWhile\tO\nApple\tO\n's\tO\nsaving\tO\ngrace\tO\nis\tO\nthe\tO\nfact\tO\nthat\tO\nthey\tO\nat\tO\nleast\tO\nstand\tO\nbehind\tO\ntheir\tO\nproducts\tO\n,\tO\nand\tO\ntheir\tO\nsupport\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nit\tO\nwould\tO\nbe\tO\nnice\tO\nif\tO\ntheir\tO\nproducts\tO\nwere\tO\nmore\tO\nreliable\tO\nto\tO\njustify\tO\nthe\tO\npremium\tO\n.\tO\n\nI\tO\nwas\tO\nready\tO\nto\tO\ntake\tO\nit\tO\nback\tO\nfor\tO\na\tO\nrefund\tO\n,\tO\nbut\tO\nthe\tO\nGeek\tB-aspectTerm\nSquad\tI-aspectTerm\ncamed\tO\nthrough\tO\nand\tO\npointed\tO\nme\tO\nin\tO\nthe\tO\nright\tO\ndirection\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\n.\tO\n\nonly\tO\ngood\tO\nthing\tO\nis\tO\nthe\tO\ngraphics\tB-aspectTerm\nquality\tI-aspectTerm\n.\tO\n\nThe\tO\nother\tO\nlock\tO\n-\tO\nup\tO\nproblems\tO\nare\tO\nfrom\tO\na\tO\nmyriad\tO\nof\tO\ncauses\tO\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nbeing\tO\na\tO\ncorrupted\tO\nversion\tO\nof\tO\nAppleworks\tB-aspectTerm\nwhich\tO\ncan\tO\nrender\tO\nthe\tO\nbrowser\tB-aspectTerm\nuseless\tO\n.\tO\n\nThe\tO\npaint\tB-aspectTerm\nwears\tO\noff\tO\neasily\tO\ndue\tO\nto\tO\nthe\tO\nkeyboard\tB-aspectTerm\nbeing\tO\nfarther\tO\nback\tO\nthan\tO\nusual\tO\n.\tO\n\nI\tO\nhad\tO\npurchased\tO\nit\tO\nfrom\tO\na\tO\nmajor\tO\nelectronics\tO\nstore\tO\nand\tO\ntook\tO\nit\tO\nto\tO\ntheir\tO\nservice\tB-aspectTerm\ndepartment\tI-aspectTerm\nto\tO\nfind\tO\nout\tO\nwhat\tO\nthe\tO\nproblem\tO\nwas\tO\n.\tO\n\nThe\tO\nstore\tO\nhonored\tO\ntheir\tO\nwarrenty\tB-aspectTerm\nand\tO\nmade\tO\nthe\tO\ncomment\tO\nthat\tO\nthey\tO\ndo\tO\nn't\tO\neven\tO\nrecommend\tO\nthe\tO\nHP\tO\nbrand\tO\nbecause\tO\nof\tO\nthe\tO\nproblems\tO\nwith\tO\ntheir\tO\nwarrentys\tB-aspectTerm\n.\tO\n\nI\tO\nalways\tO\nuse\tO\na\tO\nbackup\tO\nhard\tB-aspectTerm\ndisk\tI-aspectTerm\nto\tO\nstore\tO\nimportant\tO\nfiles\tO\nat\tO\nall\tO\ntimes\tO\n.\tO\n\nThey\tO\nsent\tO\nout\tO\nthe\tO\nbox\tO\nright\tO\naway\tO\nfor\tO\nme\tO\nto\tO\nsend\tO\nin\tO\nmy\tO\ncomputer\tO\n,\tO\nthey\tO\npaid\tO\npostage\tO\nand\tO\nwhatnot\tO\n,\tO\nbut\tO\nwhen\tO\nI\tO\ngot\tO\nmy\tO\ncomputer\tO\nback\tO\nit\tO\nstill\tO\nwas\tO\nn't\tO\nrunning\tB-aspectTerm\nright\tO\n,\tO\nand\tO\nnow\tO\nmy\tO\nCD\tB-aspectTerm\ndrive\tI-aspectTerm\nwas\tO\nn't\tO\nreading\tO\nanything\tO\n!\tO\n\nBut\tO\nthe\tO\nscreen\tB-aspectTerm\nsize\tI-aspectTerm\nis\tO\nnot\tO\nthat\tO\nbad\tO\nfor\tO\nemail\tO\nand\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\n.\tO\n\nOnce\tO\nI\tO\nremoved\tO\nall\tO\nthe\tO\nsoftware\tB-aspectTerm\nthe\tO\nlaptop\tO\nloads\tB-aspectTerm\nin\tO\n15\tO\n-\tO\n20\tO\nseconds\tO\n.\tO\n\nOn\tO\nmy\tO\nPowerBook\tO\nG4\tO\nI\tO\nwould\tO\nnever\tO\nuse\tO\nthe\tO\ntrackpad\tB-aspectTerm\nI\tO\nwould\tO\nuse\tO\nan\tO\nexternal\tB-aspectTerm\nmouse\tI-aspectTerm\nbecause\tO\nI\tO\ndid\tO\nn't\tO\nlike\tO\nthe\tO\ntrackpad\tB-aspectTerm\n.\tO\n\nThis\tO\ncomputer\tO\ndoes\tO\nn't\tO\ndo\tO\nthat\tO\nwell\tO\nwith\tO\ncertain\tO\ngames\tB-aspectTerm\nit\tO\nca\tO\nn't\tO\nplay\tO\nsome\tO\nand\tO\nit\tO\nbecomes\tO\ntoo\tO\nhot\tO\nwhile\tO\nplaying\tO\ngames\tO\n.\tO\n\nObviously\tO\none\tO\nof\tO\nthe\tO\nmost\tO\nimportant\tO\nfeatures\tB-aspectTerm\nof\tO\nany\tO\ncomputer\tO\nis\tO\nthe\tO\n\"\tO\nhuman\tO\ninterface\tO\n.\tO\n\nYeah\tO\n,\tO\nof\tO\ncourse\tO\nsmarty\tO\npants\tO\n\"\tO\nfix\tO\nit\tO\nnow\")Software\tO\n-\tO\nCompared\tO\nto\tO\nthe\tO\nearly\tO\n2011\tO\nedition\tO\nI\tO\ndid\tO\nsee\tO\ninbuilt\tB-aspectTerm\napplications\tI-aspectTerm\ncrashing\tO\nand\tO\nit\tO\nprompted\tO\nme\tO\nto\tO\nsend\tO\nthe\tO\nreport\tO\nto\tO\nApple\tO\n(\tO\nwhich\tO\nI\tO\npromptly\tO\ndid\tO\n)\tO\n.\tO\n\nThe\tO\nbody\tB-aspectTerm\nis\tO\na\tO\nbit\tO\ncheaply\tO\nmade\tO\nso\tO\nit\tO\nwill\tO\nbe\tO\ninteresting\tO\nto\tO\nsee\tO\nhow\tO\nlong\tO\nit\tO\nholds\tO\nup\tO\n.\tO\n\nThe\tO\ni5\tB-aspectTerm\nblows\tO\nmy\tO\ndesktop\tO\nout\tO\nof\tO\nthe\tO\nwater\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\nrendering\tO\nvideos\tO\n.\tO\n\nWith\tO\na\tO\nmac\tO\nyou\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tO\nabout\tO\nantivirus\tB-aspectTerm\nsoftware\tI-aspectTerm\nor\tO\nfirewall\tB-aspectTerm\n,\tO\nit\tO\n's\tO\nso\tO\nwonderful\tO\n.\tO\n\nAm\tO\nvery\tO\nglad\tO\nI\tO\nbought\tO\nit\tO\n,\tO\ngreat\tO\nnetbook\tO\n,\tO\nlow\tO\nprice\tB-aspectTerm\n.\tO\n\nThe\tO\nApple\tB-aspectTerm\nteam\tI-aspectTerm\nalso\tO\nassists\tO\nyou\tO\nvery\tO\nnicely\tO\nwhen\tO\nchoosing\tO\nwhich\tO\ncomputer\tO\nis\tO\nright\tO\nfor\tO\nyou\tO\n:)\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tO\nis\tO\nVista\tB-aspectTerm\n,\tO\nyet\tO\nI\tO\nknow\tO\nVista\tB-aspectTerm\nis\tO\nn't\tO\nthe\tO\nentire\tO\nissue\tO\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tO\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tB-aspectTerm\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n)\tO\n.\tO\n\nThe\tO\nvideo\tB-aspectTerm\nchat\tI-aspectTerm\nis\tO\nthe\tO\nonly\tO\nthing\tO\nthat\tO\nis\tO\niffy\tO\nabout\tO\nit\tO\nbut\tO\ni\tO\nm\tO\nsure\tO\nonce\tO\nthey\tO\nunpdate\tO\nthe\tO\nnext\tO\nversion\tO\non\tO\nthe\tO\nmacbook\tO\nbook\tO\nthe\tO\nquality\tB-aspectTerm\nof\tO\nit\tO\nwill\tO\nbe\tO\nbetter\tO\n.\tO\n\nThat\tO\nwhole\tO\nexperience\tO\nwas\tO\njust\tO\nridiculous\tO\nwe\tO\nsent\tO\nit\tO\nin\tO\nand\tO\nafter\tO\nthey\tO\ntold\tO\nus\tO\nthat\tO\nwe\tO\nhad\tO\nto\tO\npay\tO\n$\tO\n175\tO\nto\tO\nfix\tO\nit\tO\nwe\tO\nwere\tO\nlike\tO\nwe\tO\nwill\tO\njust\tO\nby\tO\na\tO\nportable\tO\nmouse\tB-aspectTerm\nwhich\tO\nwould\tO\nbe\tO\nway\tO\ncheaper\tO\nbut\tO\nthey\tO\nrefused\tO\nto\tO\nsend\tO\nthe\tO\nlaptop\tO\nback\tO\nuntil\tO\nwe\tO\npaid\tO\nthe\tO\n$\tO\n175\tO\nand\tO\nit\tO\nwas\tO\nfixed\tO\n.\tO\n\nFan\tB-aspectTerm\nvents\tO\nto\tO\nthe\tO\nside\tO\n,\tO\nso\tO\nno\tO\ncooling\tO\npad\tO\nneeded\tO\n,\tO\ngreat\tO\nfeature\tO\n!\tO\n\ni\tO\nuse\tO\nmy\tO\nmac\tO\nall\tO\nthe\tO\ntime\tO\n,\tO\ni\tO\nlove\tO\nthe\tO\nsoftware\tB-aspectTerm\n,\tO\nthe\tO\nway\tO\nit\tO\ntakes\tO\na\tO\nshort\tO\ntime\tO\nto\tO\nload\tO\nthings\tO\n,\tO\nhow\tO\neasy\tO\nit\tO\nis\tO\nto\tO\nuse\tO\nand\tO\nmost\tO\nof\tO\nall\tO\nhow\tO\nyou\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tO\nabout\tO\nviruses\tO\n.\tO\n\nWasted\tO\nme\tO\nat\tO\nleast\tO\n8\tO\nhours\tO\nof\tO\ninstallation\tB-aspectTerm\ntime\tI-aspectTerm\n.\tO\n\nIt\tO\nhas\tO\nfar\tO\nexceeded\tO\nmy\tO\nexpectations\tO\nfor\tO\npower\tB-aspectTerm\n,\tO\nstorage\tB-aspectTerm\n,\tO\nand\tO\nabilitiy\tB-aspectTerm\n.\tO\n\nA\tO\ngreat\tO\nfeature\tB-aspectTerm\nis\tO\nthe\tO\nspotlight\tB-aspectTerm\nsearch\tI-aspectTerm\n:\tO\none\tO\ncan\tO\nsearch\tO\nfor\tO\ndocuments\tO\nby\tO\nsimply\tO\ntyping\tO\na\tO\nkeyword\tO\n,\tO\nrather\tO\nthan\tO\nparsing\tO\ntens\tO\nof\tO\nfile\tO\nfolders\tO\nfor\tO\na\tO\ndocument\tO\n.\tO\n\nMy\tO\nwireless\tB-aspectTerm\nsystem\tI-aspectTerm\nwould\tO\nnot\tO\nrecognize\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nand\tO\nI\tO\ncould\tO\nn't\tO\nget\tO\nonline\tO\nto\tO\nfind\tO\nout\tO\nwhy\tO\n.\tO\n\nSuffice\tO\nit\tO\nto\tO\nsay\tO\n,\tO\nmy\tO\nMacBook\tO\nPro\tO\nkeeps\tO\nme\tO\ngoing\tO\nwith\tO\nits\tO\nlong\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nand\tO\nblazing\tO\nspeed\tB-aspectTerm\n.\tO\n\nThe\tO\nOS\tB-aspectTerm\nis\tO\nalso\tO\nvery\tO\nuser\tO\nfriendly\tO\n,\tO\neven\tO\nfor\tO\nthose\tO\nthat\tO\nswitch\tO\nfrom\tO\na\tO\nPC\tO\n,\tO\nwith\tO\na\tO\nlittle\tO\npractice\tO\nyou\tO\ncan\tO\ntake\tO\nfull\tO\nadvantage\tO\nof\tO\nthis\tO\nOS\tB-aspectTerm\n!\tO\n\niTunes\tB-aspectTerm\nis\tO\na\tO\nhandy\tO\nmusic\tO\n-\tO\nmanagement\tO\nprogram\tB-aspectTerm\n,\tO\nand\tO\nit\tO\nis\tO\nessential\tO\nfor\tO\nanyone\tO\nwith\tO\nan\tO\niPod\tO\n.\tO\n\nMac\tO\nis\tO\nnot\tO\nmade\tO\nfor\tO\ngaming\tB-aspectTerm\n.\tO\n\nWell\tO\nI\tO\nspilled\tO\nsomething\tO\non\tO\nit\tO\nand\tO\nthey\tO\nreplaced\tO\nit\tO\nwith\tO\nthis\tO\nmodel\tO\n,\tO\nwhich\tO\ngets\tO\nhot\tO\nand\tO\nthe\tO\nbattery\tB-aspectTerm\ndoes\tO\nn't\tO\nmake\tO\nit\tO\nthrough\tO\n1\tO\nDVD\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nto\tO\ncall\tO\nApple\tB-aspectTerm\nsupport\tI-aspectTerm\nto\tO\nset\tO\nup\tO\nmy\tO\nnew\tO\nprinter\tO\nand\tO\nhave\tO\nhad\tO\nwonderful\tO\nexperiences\tO\nwith\tO\nhelpful\tO\n,\tO\nenglish\tO\nspeaking\tO\n(\tO\nfrom\tO\nVancouver\tO\n)\tO\ntechs\tB-aspectTerm\nthat\tO\nwalked\tO\nme\tO\nthrough\tO\nthe\tO\nprocesses\tO\nto\tO\nhelp\tO\nme\tO\n.\tO\n\nBut\tO\nSony\tO\nsaid\tO\nwe\tO\ncould\tO\nsend\tO\nit\tO\nback\tO\nand\tO\nbe\tO\ncharged\tO\nfor\tO\nadding\tB-aspectTerm\nthe\tI-aspectTerm\nbluetooth\tI-aspectTerm\nan\tO\nadditional\tO\nseventy\tO\nsomething\tO\ndollars\tO\n.\tO\n\nI\tO\nneed\tO\ngraphic\tB-aspectTerm\npower\tI-aspectTerm\nto\tO\nrun\tO\nmy\tO\nAdobe\tB-aspectTerm\nCreative\tI-aspectTerm\napps\tI-aspectTerm\nefficiently\tO\n.\tO\n\nthe\tO\nprograms\tB-aspectTerm\nare\tO\nesay\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nare\tO\nquick\tO\nto\tO\nprocess\tO\nthis\tO\ncomputer\tO\nworks\tO\nlike\tO\na\tO\ncharm\tO\n.\tO\n\nThe\tO\nmaterials\tB-aspectTerm\nthat\tO\ncame\tO\nwith\tO\nthe\tO\ncomputer\tO\ndid\tO\nnot\tO\ninclude\tO\nthe\tO\nright\tO\n#\tO\nanywhere\tO\n.\tO\n\nTech\tB-aspectTerm\nsupport\tI-aspectTerm\ntells\tO\nme\tO\nthe\tO\nlatter\tO\nproblem\tO\nis\tO\na\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nproblem\tO\nand\tO\nhave\tO\noffered\tO\nto\tO\nfix\tO\nit\tO\nif\tO\nit\tO\nhappens\tO\nagain\tO\n.\tO\n\nHOW\tO\nDOES\tO\nTHE\tO\nPOWER\tB-aspectTerm\nSUPPLY\tI-aspectTerm\nNOT\tO\nWORK\tO\n!\tO\n!\tO\n!\tO\n\nSells\tO\nfor\tO\nthe\tO\nsame\tO\nas\tO\na\tO\nnetbook\tO\nwithout\tO\nsacrificing\tO\nsize\tB-aspectTerm\n.\tO\n\nÂ\tO\nupon\tO\ngiving\tO\nthem\tO\nthe\tO\nserial\tO\nnumber\tO\nthe\tO\nfirst\tO\nthing\tO\nI\tO\nwas\tO\ntold\tO\n,\tO\nwas\tO\nthat\tO\nit\tO\nwas\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\nand\tO\nI\tO\ncould\tO\npay\tO\nto\tO\nhave\tO\nit\tO\nrepaired\tO\n.\tO\n\nWindows\tB-aspectTerm\nXP\tI-aspectTerm\nSP2\tI-aspectTerm\ncaused\tO\nmany\tO\nproblems\tO\non\tO\nthe\tO\ncomputer\tO\n,\tO\nso\tO\nI\tO\nhad\tO\nto\tO\nremove\tO\nit\tO\n.\tO\n\nI\tO\nreloaded\tO\nwith\tO\nWindows\tO\n7\tO\nUltimate\tO\n,\tO\nand\tO\nthe\tO\nBluetooth\tB-aspectTerm\nand\tO\nFingerprint\tB-aspectTerm\nreader\tI-aspectTerm\n(\tO\nsoftware\tB-aspectTerm\n)\tO\nwould\tO\nnot\tO\nload\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\ntechs\tB-aspectTerm\nat\tI-aspectTerm\nHP\tI-aspectTerm\nknew\tO\nwhat\tO\nthey\tO\nwere\tO\ndoing\tO\n.\tO\n\nthis\tO\nis\tO\nmy\tO\nsecond\tO\none\tO\nand\tO\nthe\tO\nsame\tO\nproblem\tO\n,\tO\nbad\tO\nvideo\tB-aspectTerm\ncard\tI-aspectTerm\nO\tO\nunreliable\tO\noverall\tO\n,\tO\nthis\tO\nwill\tO\nbe\tO\nmy\tO\nsecond\tO\ntime\tO\nreturning\tO\nthis\tO\nlaptop\tO\nback\tO\nto\tO\nbest\tO\nbuy\tO\n.\tO\n\nWith\tO\nawesome\tO\ngraphics\tO\nand\tO\nassuring\tO\nsecurity\tB-aspectTerm\n,\tO\nit\tO\n's\tO\nperfect\tO\n!\tO\n\nLaptop\tO\nwas\tO\nin\tO\nnew\tO\ncondition\tO\nand\tO\noperational\tO\n,\tO\nbut\tO\nfor\tO\nthe\tO\naudio\tB-aspectTerm\nproblem\tO\nwhen\tO\n1st\tO\nsent\tO\nfor\tO\nrepair\tO\n.\tO\n\nI\tO\nwas\tO\ndisappointed\tO\nwhen\tO\nI\tO\nrealized\tO\nthat\tO\nthe\tO\nkeyboard\tB-aspectTerm\ndoes\tO\nn't\tO\nlight\tO\nup\tO\non\tO\nthis\tO\nmodel\tO\n.\tO\n\nIt\tO\nruns\tB-aspectTerm\nperfectly\tO\n.\tO\n\nThe\tO\nlaptop\tO\nwas\tO\nvery\tO\neasy\tO\nto\tO\nset\tB-aspectTerm\nup\tI-aspectTerm\n.\tO\n\nÂ\tO\nSometimes\tO\nthe\tO\nscreen\tB-aspectTerm\neven\tO\ngoes\tO\nblack\tO\non\tO\nthis\tO\ncomputer\tO\n.\tO\n\nI\tO\nrecommend\tO\nfor\tO\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\nand\tO\ninternet\tO\nusers\tO\n.\tO\n\nSince\tO\nI\tO\n've\tO\nhad\tO\nthis\tO\ncomputer\tO\nI\tO\n've\tO\nonly\tO\nused\tO\nthe\tO\ntrackpad\tB-aspectTerm\nbecause\tO\nit\tO\nis\tO\nso\tO\nnice\tO\nand\tO\nsmooth\tO\n.\tO\n\nA\tO\nlonger\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwould\tO\nhave\tO\nbeen\tO\ngreat\tO\n-\tO\nbut\tO\nit\tO\nmeets\tO\nit\tO\n's\tO\nspec\tB-aspectTerm\nquite\tO\neasily\tO\n.\tO\n\nWho\tO\ncould\tO\nn't\tO\nlove\tO\na\tO\nDVD\tB-aspectTerm\nburner\tI-aspectTerm\n,\tO\n80-gigabyte\tO\nHD\tB-aspectTerm\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tB-aspectTerm\nchip\tI-aspectTerm\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tO\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tO\nand\tO\nToshiba\tO\nmachines\tO\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tO\n-\tO\nquality\tO\ncomponents\tB-aspectTerm\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tO\n\nIts\tO\nfast\tO\nand\tO\nanother\tO\nthing\tO\nI\tO\nlike\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\nthree\tO\nUSB\tB-aspectTerm\nports\tI-aspectTerm\n.\tO\n\nThe\tO\nsalesman\tO\ntalked\tO\nus\tO\ninto\tO\nthis\tO\ncomputer\tO\naway\tO\nfrom\tO\nanother\tO\nwe\tO\nwere\tO\nlooking\tO\nat\tO\nand\tO\nwe\tO\nhave\tO\nhad\tO\nnothing\tO\nbut\tO\nproblems\tO\nwith\tO\nsoftware\tB-aspectTerm\nproblems\tO\nand\tO\njust\tO\nnot\tO\nhappy\tO\nwith\tO\nit\tO\n.\tO\n\nThat\tO\nsystem\tB-aspectTerm\nis\tO\nfixed\tO\n.\tO\n\nLike\tO\nthe\tO\nprice\tB-aspectTerm\nand\tO\noperation\tB-aspectTerm\n.\tO\n\nThe\tO\nbrand\tB-aspectTerm\nis\tO\ntarnished\tO\nin\tO\nmy\tO\nheart\tO\n.\tO\n\nThis\tO\nis\tO\nlikely\tO\ndue\tO\nto\tO\npoor\tO\ngrounding\tO\nand\tO\nisolation\tO\nbetween\tO\nthe\tO\ncomponents\tB-aspectTerm\n,\tO\nand\tO\nI\tO\n'm\tO\nhoping\tO\nthat\tO\nit\tO\ncan\tO\nbe\tO\nfixed\tO\nwith\tO\na\tO\nground\tB-aspectTerm\nloop\tI-aspectTerm\nisolator\tI-aspectTerm\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tO\nbetter\tO\nproduct\tO\nquality\tB-aspectTerm\nfor\tO\nthis\tO\nprice\tB-aspectTerm\nrange\tI-aspectTerm\n.\tO\n\nI\tO\n'\tO\nhave\tO\nhad\tO\nit\tO\nfor\tO\nabout\tO\na\tO\n1\tO\n1/2\tO\nand\tO\nyes\tO\nI\tO\nhave\tO\nhad\tO\nan\tO\nissue\tO\nwith\tO\nit\tO\none\tO\nmonth\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\n.\tO\n\nOnce\tO\nopen\tO\n,\tO\nthe\tO\nleading\tB-aspectTerm\nedge\tI-aspectTerm\nis\tO\nrazor\tO\nsharp\tO\n.\tO\n\nLoaded\tO\nwith\tO\nbloatware\tB-aspectTerm\n.\tO\n\nMaximum\tB-aspectTerm\nsound\tI-aspectTerm\nis\tO\nn't\tO\nnearly\tO\nas\tO\nloud\tO\nas\tO\nit\tO\nshould\tO\nbe\tO\n.\tO\n\nI\tO\nloaded\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nvia\tO\nBootcamp\tB-aspectTerm\nand\tO\nit\tO\nworks\tO\nflawlessly\tO\n!\tO\n\nGreat\tO\nLaptop\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n,\tO\nworks\tB-aspectTerm\nwell\tO\nwith\tO\naction\tB-aspectTerm\npack\tI-aspectTerm\ngames\tI-aspectTerm\n.\tO\n\nAlthough\tO\nthe\tO\nprice\tB-aspectTerm\nis\tO\nhigher\tO\nthen\tO\nDell\tO\nlaptops\tO\n,\tO\nthe\tO\nMacbooks\tO\nare\tO\nworth\tO\nthe\tO\ndough\tO\n.\tO\n\nI\tO\nwould\tO\nnot\tO\nrecommend\tO\nthis\tO\nto\tO\nanyone\tO\nwanting\tO\na\tO\nnotebook\tO\nexpecting\tO\nthe\tO\nperformance\tB-aspectTerm\nof\tO\na\tO\nDesktop\tO\nit\tO\ndoes\tO\nnot\tO\nmeet\tO\nthe\tO\nexpectations\tO\n.\tO\n\nThe\tO\nMacbook\tO\narrived\tO\nin\tO\na\tO\nnice\tO\ntwin\tB-aspectTerm\npacking\tI-aspectTerm\nand\tO\nsealed\tO\nin\tO\nthe\tO\nbox\tO\n,\tO\nall\tO\nthe\tO\nfunctions\tB-aspectTerm\nworks\tO\ngreat\tO\n.\tO\n\nSo\tO\nwhat\tO\nif\tO\nthe\tO\nlaptops\tO\n/\tO\nmobile\tO\nphones\tO\nlook\tB-aspectTerm\nchic\tO\nand\tO\ncool\tO\n?\tO\nThe\tO\nafter\tB-aspectTerm\nsales\tI-aspectTerm\nsupport\tI-aspectTerm\nis\tO\nterrible\tO\n.\tO\n\nI\tO\nhate\tO\nthe\tO\ndisplay\tB-aspectTerm\nscreen\tI-aspectTerm\nand\tO\nI\tO\nhave\tO\ndone\tO\neverything\tO\nI\tO\ncould\tO\ndo\tO\nthe\tO\nchange\tO\nit\tO\n.\tO\n\nI\tO\nalso\tO\nlike\tO\nthe\tO\nacer\tB-aspectTerm\narcade\tI-aspectTerm\nbut\tO\nthese\tO\nwere\tO\nreallythe\tO\nonly\tO\ntwo\tO\nthings\tO\nI\tO\nliked\tO\nabout\tO\nthis\tO\nlaptop\tO\n.\tO\n\nHave\tO\nnot\tO\nyet\tO\nneeded\tO\nany\tO\ncustomer\tB-aspectTerm\nsupport\tI-aspectTerm\nwith\tO\nthis\tO\nyet\tO\nso\tO\nto\tO\nme\tO\nthat\tO\nis\tO\na\tO\ngreat\tO\nthing\tO\n,\tO\nwhich\tO\nis\tO\nleaps\tO\nand\tO\nbounds\tO\nahead\tO\nof\tO\nPC\tO\nin\tO\nmy\tO\nopinion\tO\n.\tO\n\nI\tO\ngave\tO\nit\tO\nto\tO\nmy\tO\ndaughter\tO\nbecause\tO\nI\tO\njust\tO\nhated\tO\nthe\tO\nscreen\tB-aspectTerm\n,\tO\nhated\tO\nthat\tO\nit\tO\nhad\tO\nno\tO\ncd\tB-aspectTerm\ndrive\tI-aspectTerm\nto\tO\nat\tO\nleast\tO\nplay\tO\ncd\tO\n's\tO\nwhen\tO\nI\tO\nwanted\tO\nto\tO\nlisten\tO\nto\tO\nmusic\tO\nand\tO\ndo\tO\nschoolwork\tO\n.\tO\n\nIt\tO\nruns\tB-aspectTerm\nvery\tO\nquiet\tO\ntoo\tO\nwhich\tO\nis\tO\na\tO\nplus\tO\n.\tO\n\nIt\tO\nwas\tO\nheavy\tO\n,\tO\nbulky\tO\n,\tO\nand\tO\nhard\tO\nto\tO\ncarry\tO\nbecause\tO\nof\tO\nthe\tO\nsize\tB-aspectTerm\n.\tO\n\nThe\tO\ngames\tB-aspectTerm\nincluded\tO\nare\tO\nvery\tO\ngood\tO\ngames\tB-aspectTerm\n.\tO\n\nthis\tO\ncomputer\tO\nwill\tO\nlast\tO\nyou\tO\nat\tO\nleast\tO\n7\tO\nyears\tO\n,\tO\nthat\tO\ns\tO\nan\tO\namazing\tO\nlife\tB-aspectTerm\nspanned\tO\nan\tO\nelectronic\tO\n.\tO\n\nSometimes\tO\nyou\tO\nreally\tO\nhave\tO\nto\tO\ntap\tO\nthe\tO\npad\tB-aspectTerm\nto\tO\nget\tO\nit\tO\nto\tO\nworki\tO\n\nIt\tO\n's\tO\nsuper\tO\nfast\tO\nand\tO\na\tO\ngreat\tO\nvalue\tB-aspectTerm\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n!\tO\n\nThree\tO\n,\tO\nthe\tO\nmac\tO\nbook\tO\nhas\tO\nadvantages\tO\nover\tO\npcs\tO\n'\tO\nwith\tO\nlinux\tB-aspectTerm\nbased\tI-aspectTerm\nos\tI-aspectTerm\nthere\tO\nis\tO\nvery\tO\n'\tO\nfew\tO\nproblems\tO\nwith\tO\nsystem\tB-aspectTerm\nperformance\tI-aspectTerm\nwhen\tO\nit\tO\ncomes\tO\nto\tO\na\tO\nmac\tO\n.\tO\n\nA\tO\nmac\tO\nis\tO\nvery\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nit\tO\nsimply\tO\nmakes\tO\nsense\tO\n.\tO\n\nhowever\tO\n,\tO\nI\tO\nmay\tO\nhave\tO\ninadvertently\tO\nthrown\tO\nout\tO\none\tO\nof\tO\nthe\tO\nbatteries\tB-aspectTerm\nwith\tO\nthe\tO\nshipping\tB-aspectTerm\ncarton\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nso\tO\nmuch\tO\neasier\tO\nto\tO\nuse\tB-aspectTerm\n\nThere\tO\nis\tO\nno\tO\nneed\tO\nto\tO\nopen\tO\na\tO\nprogram\tB-aspectTerm\nfirst\tO\nand\tO\nthe\tO\ncliick\tO\nopen\tO\nor\tO\nimport\tO\n.\tO\n\nIt\tO\nis\tO\nso\tO\nnice\tO\nnot\tO\nto\tO\nworry\tO\nabout\tO\nthat\tO\nand\tO\nthe\tO\nextra\tO\nexpense\tO\nthat\tO\ncomes\tO\nalong\tO\nwith\tO\nthe\tO\nnecessary\tO\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\non\tO\nPC\tO\n's\tO\n.\tO\n\nThree\tO\nweeks\tO\nafter\tO\nI\tO\nbought\tO\nthe\tO\nnetbook\tO\n,\tO\nthe\tO\nscreen\tB-aspectTerm\nquit\tO\nworking\tO\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tO\nOSX\tB-aspectTerm\n16\tI-aspectTerm\nfunctions\tO\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tB-aspectTerm\nare\tO\nrouted\tO\nthrough\tO\nthe\tO\nhardware\tB-aspectTerm\nrather\tO\nthan\tO\nthe\tO\nsoftware\tB-aspectTerm\n.\tO\n\nI\tO\nwanted\tO\nsomething\tO\nthat\tO\nhad\tO\na\tO\nnew\tO\nIntel\tB-aspectTerm\nCore\tI-aspectTerm\nprocessors\tI-aspectTerm\nand\tO\nHDMI\tB-aspectTerm\nport\tI-aspectTerm\nso\tO\nthat\tO\nwe\tO\ncould\tO\nhook\tO\nit\tO\nup\tO\ndirectly\tO\nto\tO\nour\tO\nTV\tO\n.\tO\n\nThe\tO\nApple\tO\nwill\tO\nrun\tO\nInternet\tB-aspectTerm\nExplorer\tI-aspectTerm\n,\tO\nbut\tO\nat\tO\nan\tO\namazingly\tO\nslow\tO\nrate\tO\n.\tO\n\nWith\tO\ntoday\tO\n's\tO\ncompany\tO\nfighting\tO\nover\tO\nmarketshare\tO\n,\tO\nits\tO\na\tO\nshame\tO\nthat\tO\nASUS\tO\ncan\tO\nget\tO\naway\tO\nwith\tO\nthe\tO\ninept\tO\nstaff\tB-aspectTerm\nanswering\tO\nthephone\tO\n.\tO\n\nThe\tO\nprice\tB-aspectTerm\npremium\tI-aspectTerm\nis\tO\na\tO\nlittle\tO\nmuch\tO\n,\tO\nbut\tO\nwhen\tO\nyou\tO\nstart\tO\nlooking\tO\nat\tO\nthe\tO\nfeatures\tB-aspectTerm\nit\tO\nis\tO\nworth\tO\nthe\tO\nadded\tO\ncash\tO\n.\tO\n\nMicrosoft\tB-aspectTerm\nword\tI-aspectTerm\nwas\tO\nnot\tO\non\tO\nit\tO\nandI\tO\nhad\tO\nto\tO\nbuy\tO\nit\tO\nseperately\tO\n.\tO\n\nit\tO\nhas\tO\n3\tO\nusb\tB-aspectTerm\nports\tI-aspectTerm\n,\tO\n1\tO\nsd\tB-aspectTerm\nmemory\tI-aspectTerm\ncard\tI-aspectTerm\nreader\tI-aspectTerm\nand\tO\nan\tO\nsd\tB-aspectTerm\nmemory\tI-aspectTerm\ncar\tI-aspectTerm\nexpansion\tI-aspectTerm\n.\tO\n\nI\tO\nconnect\tO\na\tO\nLaCie\tB-aspectTerm\n2Big\tI-aspectTerm\nexternal\tI-aspectTerm\ndrive\tI-aspectTerm\nvia\tO\nthe\tO\nfirewire\tB-aspectTerm\n800\tI-aspectTerm\ninterface\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\nuseful\tO\nfor\tO\nTime\tB-aspectTerm\nMachine\tI-aspectTerm\n.\tO\n\nMy\tO\nToshiba\tO\ndid\tO\nnot\tO\nhave\tO\nsound\tB-aspectTerm\non\tO\neverything\tO\n,\tO\njust\tO\ncertain\tO\nthings\tO\n.\tO\n\nI\tO\nam\tO\noverall\tO\nvery\tO\npleased\tO\nwith\tO\nmy\tO\ntoshiba\tO\nsatellite\tO\n,\tO\nI\tO\nlike\tO\nthe\tO\nextra\tB-aspectTerm\nfeatures\tI-aspectTerm\n,\tO\nI\tO\nlove\tO\nthe\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nhome\tI-aspectTerm\npremium\tI-aspectTerm\n.\tO\n\nThe\tO\nAspire\tO\nwo\tO\nnt\tO\neven\tO\nboot\tB-aspectTerm\npast\tO\nthe\tO\nAcer\tB-aspectTerm\nscreen\tI-aspectTerm\nwith\tO\na\tO\nDroid\tO\n(\tO\nI\tO\nhave\tO\ntried\tO\nboth\tO\nMotorola\tO\nand\tO\nHTC\tO\n)\tO\nplugged\tO\ninto\tO\nthe\tO\nUSB\tB-aspectTerm\nport\tI-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwas\tO\nshorter\tO\nthan\tO\nexpected\tO\n.\tO\n\nIt\tO\nfires\tB-aspectTerm\nup\tI-aspectTerm\nin\tO\nthe\tO\nmorning\tO\nin\tO\nless\tO\nthan\tO\n30\tO\nseconds\tO\nand\tO\nI\tO\nhave\tO\nnever\tO\nhad\tO\nany\tO\nissues\tO\nwith\tO\nit\tO\nfreezing\tO\n.\tO\n\nThe\tO\nkeyboard\tB-aspectTerm\nis\tO\ntop\tO\nnotch\tO\n.\tO\n\nIt\tO\ndrives\tO\nme\tO\ncrazy\tO\nwhen\tO\nI\tO\nwant\tO\nto\tO\ndownload\tO\na\tO\ngame\tO\nor\tO\nsomething\tO\nof\tO\nthat\tO\nnature\tO\nand\tO\nI\tO\nca\tO\nn't\tO\nplay\tO\nit\tO\nbecause\tO\nits\tO\nnot\tO\ncompatable\tO\nwith\tO\nthe\tO\nsoftware\tB-aspectTerm\n.\tO\n\nThe\tO\nonline\tB-aspectTerm\ntutorial\tI-aspectTerm\nvideos\tI-aspectTerm\nmake\tO\nit\tO\nsuper\tO\neasy\tO\nto\tO\nlearn\tO\nif\tO\nyou\tO\nhave\tO\nalways\tO\nused\tO\na\tO\nPC\tO\n.\tO\n\nThe\tO\nimage\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nand\tO\nthe\tO\nsoud\tB-aspectTerm\nis\tO\nexcelent\tO\n.\tO\n\nWith\tO\na\tO\nMAC\tO\ncomputer\tO\nI\tO\nhave\tO\nmore\tO\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nwait\tO\nfor\tO\nwindows\tB-aspectTerm\nto\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nor\tO\nshut\tB-aspectTerm\ndown\tI-aspectTerm\nand\tO\nall\tO\nthe\tO\nviruses\tO\nassociated\tO\nwith\tO\nwindows\tB-aspectTerm\n.\tO\n\nIt\tO\nwas\tO\nvery\tO\neasy\tO\nto\tO\njust\tO\npick\tO\nup\tO\nand\tO\nuse--\tB-aspectTerm\nIt\tO\ndid\tO\nnot\tO\ntake\tO\nlong\tO\nto\tO\nget\tO\nused\tO\nto\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nwell\tO\nworth\tO\nthe\tO\nmoney\tO\nit\tO\ncost\tB-aspectTerm\n,\tO\nVery\tO\ngood\tO\ninvestment\tO\n.\tO\n\nUpgrading\tO\nfrom\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nStarter\tI-aspectTerm\n,\tO\nthru\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nHome\tI-aspectTerm\nPremium\tI-aspectTerm\n,\tO\nto\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nProfessional\tI-aspectTerm\nwas\tO\na\tO\nsnap\tO\n;\tO\n\nMy\tO\nkids\tO\n(\tO\nand\tO\ndogs\tO\n)\tO\ndestroyed\tO\ntwo\tO\npower\tB-aspectTerm\ncords\tI-aspectTerm\nby\tO\npulling\tO\non\tO\nthem\tO\n.\tO\n\nI\tO\nhad\tO\nupgraded\tO\nmy\tO\nold\tO\nMacBook\tO\nto\tO\nLion\tO\n,\tO\nso\tO\nI\tO\nkind\tO\nof\tO\nknew\tO\nwhat\tO\nI\tO\nwas\tO\ngetting\tO\n,\tO\nbut\tO\nhad\tO\nn't\tO\nbeen\tO\nable\tO\nto\tO\nenjoy\tO\nsome\tO\nof\tO\nthe\tO\nawesome\tO\nnew\tO\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\nfeatures\tI-aspectTerm\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\na\tO\nlittle\tO\nglary\tO\n,\tO\nand\tO\nI\tO\nhated\tO\nthe\tO\nclicking\tB-aspectTerm\nbuttons\tI-aspectTerm\n,\tO\nbut\tO\nI\tO\ngot\tO\nused\tO\nto\tO\nthem\tO\n.\tO\n\nnot\tO\nusing\tO\nwired\tB-aspectTerm\nlan\tI-aspectTerm\nnot\tO\nsure\tO\nwhat\tO\nthat\tO\ns\tO\nabout\tO\n.\tO\n\nThe\tO\nmacbook\tO\nrarely\tO\nrequires\tO\na\tO\nhard\tB-aspectTerm\nreboot\tI-aspectTerm\n.\tO\n\nNow\tO\nfor\tO\nthe\tO\nhardware\tB-aspectTerm\nproblems\tO\n.\tO\n\nAnyways\tO\nI\tO\nbought\tO\nthis\tO\ntwo\tO\nmonths\tO\nago\tO\nand\tO\nwhen\tO\nI\tO\nfirst\tO\nbrought\tO\nit\tO\nhome\tO\nit\tO\nkept\tO\ngiving\tO\nme\tO\na\tO\nmessage\tO\nabout\tO\na\tO\nvibration\tO\nin\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nit\tO\nis\tO\nputting\tO\nit\tO\ntemporaly\tO\nin\tO\nsave\tO\nzone\tO\n.\tO\n\nIt\tO\n's\tO\nfast\tO\nand\tO\nhas\tO\nexcellent\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nFeatures\tB-aspectTerm\nlike\tO\nthe\tO\nfont\tB-aspectTerm\nare\tO\nvery\tO\nblock\tO\n-\tO\nlike\tO\nand\tO\nold\tO\nschool\tO\n.\tO\n\nIt\tO\nis\tO\nloaded\tO\nwith\tO\nprograms\tB-aspectTerm\nthat\tO\nis\tO\nof\tO\nno\tO\ngood\tO\nfor\tO\nthe\tO\naverage\tO\nuser\tO\n,\tO\nthat\tO\nmakes\tO\nit\tO\nrun\tB-aspectTerm\nway\tO\nto\tO\nslow\tO\n.\tO\n\nI\tO\nfeel\tO\nthat\tO\nit\tO\nwas\tO\npoorly\tO\nput\tO\ntogether\tO\n,\tO\nbecause\tO\nonce\tO\nin\tO\na\tO\nwhile\tO\ndifferent\tO\nplastic\tB-aspectTerm\nÂ\tI-aspectTerm\npieces\tI-aspectTerm\nÂ\tO\nwould\tO\ncome\tO\noff\tO\nof\tO\nit\tO\n.\tO\n\nFinally\tO\n,\tO\nI\tO\nshould\tO\nnote\tO\nthat\tO\nI\tO\ntook\tO\nthe\tO\n2\tB-aspectTerm\nGB\tI-aspectTerm\nRAM\tI-aspectTerm\nstick\tI-aspectTerm\nfrom\tO\nmy\tO\nold\tO\nEeePC\tO\nand\tO\ninstalled\tO\nit\tO\nbefore\tO\nI\tO\neven\tO\npowered\tO\non\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\n.\tO\n\nWindows\tB-aspectTerm\nis\tO\nalso\tO\nrather\tO\nunsteady\tO\non\tO\nits\tO\nfeet\tO\nand\tO\nis\tO\nsusceptible\tO\nto\tO\nmany\tO\nbugs\tO\n.\tO\n\nAfter\tO\nsending\tO\nout\tO\ndocuments\tO\nvia\tO\nemail\tO\nand\tO\nhaving\tO\nrecipients\tO\ntell\tO\nme\tO\nthey\tO\ncould\tO\nnot\tO\nopen\tO\nthe\tO\ndocuments\tO\nor\tO\nthey\tO\ncame\tO\nthrough\tO\nas\tO\ngibberish\tO\n,\tO\nI\tO\nbroke\tO\ndown\tO\nand\tO\nspent\tO\nanother\tO\n$\tO\n100\tO\nto\tO\nget\tO\nMicrosoft\tB-aspectTerm\nWord\tI-aspectTerm\nfor\tI-aspectTerm\nMac\tI-aspectTerm\n.\tO\n\n"
  },
  {
    "path": "dataset/Laptop-reviews/trigger_20.txt",
    "content": "I\tO\ncharge\tT-1\nit\tT-1\nat\tO\nnight\tO\nand\tO\nskip\tT-0\ntaking\tT-0\nthe\tT-0\ncord\tB-aspectTerm\nwith\tO\nme\tO\nbecause\tO\nof\tO\nthe\tO\ngood\tO\nbattery\tO\nlife\tO\n.\tO\n\nI\tO\ncharge\tT-0\nit\tO\nat\tO\nnight\tO\nand\tO\nskip\tO\ntaking\tO\nthe\tO\ncord\tT-1\nwith\tO\nme\tO\nbecause\tT-2\nof\tO\nthe\tO\ngood\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nThe\tO\ntech\tB-aspectTerm\nguy\tI-aspectTerm\nthen\tO\nsaid\tO\nthe\tO\nservice\tT-1\ncenter\tT-1\ndoes\tO\nnot\tO\ndo\tO\n1-to-1\tO\nexchange\tO\nand\tO\nI\tO\nhave\tO\nto\tO\ndirect\tO\nmy\tO\nconcern\tO\nto\tO\nthe\tO\n\"\tO\nsales\tT-0\n\"\tO\nteam\tO\n,\tO\nwhich\tO\nis\tO\nthe\tO\nretail\tT-2\nshop\tT-2\nwhich\tO\nI\tO\nbought\tO\nmy\tO\nnetbook\tT-3\nfrom\tO\n.\tO\n\nThe\tO\ntech\tT-0\nguy\tT-0\nthen\tO\nsaid\tO\nthe\tO\nservice\tB-aspectTerm\ncenter\tI-aspectTerm\ndoes\tO\nnot\tO\ndo\tO\n1-to-1\tO\nexchange\tO\nand\tO\nI\tO\nhave\tO\nto\tO\ndirect\tO\nmy\tO\nconcern\tO\nto\tO\nthe\tO\n\"\tO\nsales\tO\n\"\tO\nteam\tO\n,\tO\nwhich\tO\nis\tO\nthe\tO\nretail\tO\nshop\tO\nwhich\tO\nI\tO\nbought\tO\nmy\tO\nnetbook\tO\nfrom\tO\n.\tO\n\nThe\tO\ntech\tT-0\nguy\tT-0\nthen\tO\nsaid\tO\nthe\tO\nservice\tT-1\ncenter\tT-1\ndoes\tO\nnot\tO\ndo\tO\n1-to-1\tO\nexchange\tO\nand\tO\nI\tO\nhave\tO\nto\tO\ndirect\tO\nmy\tO\nconcern\tO\nto\tO\nthe\tO\n\"\tB-aspectTerm\nsales\tI-aspectTerm\n\"\tI-aspectTerm\nteam\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\nthe\tO\nretail\tT-2\nshop\tT-2\nwhich\tO\nI\tO\nbought\tO\nmy\tO\nnetbook\tO\nfrom\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tB-aspectTerm\n,\tO\nhas\tO\na\tO\nkiller\tO\nGUI\tT-0\n,\tO\nis\tO\nextremely\tO\nstable\tT-1\n,\tO\nis\tO\nhighly\tO\nexpandable\tO\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tO\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tO\n,\tO\nhas\tT-0\na\tT-0\nkiller\tT-0\nGUI\tB-aspectTerm\n,\tO\nis\tO\nextremely\tO\nstable\tT-1\n,\tO\nis\tO\nhighly\tO\nexpandable\tO\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tO\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tT-0\n,\tO\nhas\tO\na\tO\nkiller\tO\nGUI\tT-1\n,\tO\nis\tO\nextremely\tT-3\nstable\tO\n,\tO\nis\tO\nhighly\tO\nexpandable\tT-2\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tB-aspectTerm\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tO\n,\tO\nhas\tO\na\tO\nkiller\tO\nGUI\tT-0\n,\tO\nis\tO\nextremely\tO\nstable\tO\n,\tO\nis\tO\nhighly\tO\nexpandable\tT-1\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tO\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tT-0\nof\tT-0\nthe\tT-0\nfeatures\tB-aspectTerm\nthat\tT-1\nit\tT-1\noffers\tT-1\n,\tO\nlike\tO\n,\tO\niChat\tT-2\n,\tO\nPhotobooth\tT-3\n,\tO\ngarage\tO\nband\tO\nand\tO\nmore\tO\n!\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nfeatures\tO\nthat\tO\nit\tO\noffers\tO\n,\tO\nlike\tO\n,\tO\niChat\tB-aspectTerm\n,\tO\nPhotobooth\tT-0\n,\tO\ngarage\tT-1\nband\tT-2\nand\tO\nmore\tO\n!\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nfeatures\tT-0\nthat\tO\nit\tO\noffers\tO\n,\tO\nlike\tO\n,\tO\niChat\tT-1\n,\tO\nPhotobooth\tB-aspectTerm\n,\tO\ngarage\tT-2\nband\tT-2\nand\tO\nmore\tO\n!\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nfeatures\tO\nthat\tO\nit\tT-0\noffers\tO\n,\tO\nlike\tO\n,\tO\niChat\tO\n,\tO\nPhotobooth\tO\n,\tO\ngarage\tB-aspectTerm\nband\tI-aspectTerm\nand\tO\nmore\tO\n!\tO\n\nGreat\tO\nlaptop\tT-1\nthat\tO\noffers\tT-0\nmany\tT-0\ngreat\tT-0\nfeatures\tB-aspectTerm\n!\tO\n\nÂ\tO\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tB-aspectTerm\n,\tO\nscreen\tO\nall\tO\ndark\tO\n,\tO\npower\tO\nlight\tO\nsteady\tO\n,\tO\nhard\tO\ndrive\tO\nlight\tO\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tT-1\n\nÂ\tO\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tO\n,\tO\nscreen\tB-aspectTerm\nall\tO\ndark\tO\n,\tO\npower\tO\nlight\tO\nsteady\tO\n,\tO\nhard\tO\ndrive\tO\nlight\tO\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tT-1\n\nÂ\tO\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tO\n,\tO\nscreen\tO\nall\tO\ndark\tO\n,\tO\npower\tB-aspectTerm\nlight\tI-aspectTerm\nsteady\tO\n,\tO\nhard\tO\ndrive\tO\nlight\tO\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tT-1\n\nÂ\tO\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tO\n,\tO\nscreen\tO\nall\tO\ndark\tO\n,\tO\npower\tO\nlight\tO\nsteady\tO\n,\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nlight\tI-aspectTerm\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tT-1\n\nI\tO\ntook\tO\nit\tO\nback\tO\nfor\tO\nan\tO\nAsus\tT-0\nand\tO\nsame\tO\nthing-\tO\nblue\tO\nscreen\tO\nwhich\tO\nrequired\tO\nme\tO\nto\tO\nremove\tT-1\nthe\tO\nbattery\tB-aspectTerm\nto\tO\nreset\tO\n.\tO\n\nIn\tO\nthe\tO\nshop\tO\n,\tO\nthese\tO\nMacBooks\tT-1\nare\tO\nencased\tO\nin\tO\na\tO\nsoft\tT-0\nrubber\tB-aspectTerm\nenclosure\tI-aspectTerm\n-\tO\nso\tO\nyou\tO\nwill\tO\nnever\tO\nknow\tO\nabout\tO\nthe\tO\nrazor\tT-2\nedge\tT-2\nuntil\tO\nyou\tO\nbuy\tO\nit\tO\n,\tO\nget\tO\nit\tO\nhome\tO\n,\tO\nbreak\tO\nthe\tO\nseal\tO\nand\tO\nuse\tO\nit\tO\n(\tO\nvery\tO\nclever\tO\ncon\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\nshop\tO\n,\tO\nthese\tO\nMacBooks\tT-1\nare\tO\nencased\tT-2\nin\tO\na\tO\nsoft\tO\nrubber\tT-3\nenclosure\tT-3\n-\tO\nso\tO\nyou\tO\nwill\tO\nnever\tO\nknow\tO\nabout\tO\nthe\tO\nrazor\tT-0\nedge\tB-aspectTerm\nuntil\tO\nyou\tO\nbuy\tO\nit\tO\n,\tO\nget\tO\nit\tO\nhome\tO\n,\tO\nbreak\tO\nthe\tO\nseal\tO\nand\tO\nuse\tO\nit\tO\n(\tO\nvery\tO\nclever\tO\ncon\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\ngestures\tI-aspectTerm\nand\tO\nlarge\tO\ntracking\tT-0\narea\tO\nmake\tO\nhaving\tO\nan\tO\nexternal\tO\nmouse\tO\nunnecessary\tO\n(\tO\nunless\tO\nyou\tO\n're\tO\ngaming\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tT-1\n-\tT-1\ntouch\tT-1\ngestures\tO\nand\tO\nlarge\tO\ntracking\tB-aspectTerm\narea\tI-aspectTerm\nmake\tO\nhaving\tO\nan\tO\nexternal\tT-0\nmouse\tO\nunnecessary\tO\n(\tO\nunless\tO\nyou\tO\n're\tO\ngaming\tT-2\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tT-0\n-\tT-0\ntouch\tT-0\ngestures\tO\nand\tO\nlarge\tO\ntracking\tT-1\narea\tT-1\nmake\tO\nhaving\tO\nan\tO\nexternal\tB-aspectTerm\nmouse\tI-aspectTerm\nunnecessary\tT-3\n(\tO\nunless\tO\nyou\tO\n're\tO\ngaming\tT-2\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tO\n-\tO\ntouch\tO\ngestures\tO\nand\tO\nlarge\tO\ntracking\tO\narea\tO\nmake\tO\nhaving\tO\nan\tO\nexternal\tT-1\nmouse\tO\nunnecessary\tO\n(\tO\nunless\tT-0\nyou\tT-0\n're\tT-0\ngaming\tB-aspectTerm\n)\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nway\tO\nthe\tO\nentire\tO\nsuite\tB-aspectTerm\nof\tI-aspectTerm\nsoftware\tI-aspectTerm\nworks\tO\ntogether\tT-0\n.\tO\n\nThe\tO\nspeed\tB-aspectTerm\nis\tO\nincredible\tT-1\nand\tO\nI\tO\nam\tO\nmore\tO\nthan\tO\nsatisfied\tT-0\n.\tO\n\nThis\tO\nlaptop\tT-1\nmeets\tO\nevery\tO\nexpectation\tO\nand\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nis\tT-0\ngreat\tT-0\n!\tO\n\nI\tO\ncan\tO\nbarely\tO\nuse\tT-1\nany\tO\nusb\tB-aspectTerm\ndevices\tI-aspectTerm\nbecause\tO\nthey\tO\nwill\tO\nnot\tO\nstay\tO\nconnected\tT-0\nproperly\tO\n.\tO\n\nWhen\tO\nI\tO\nfinally\tO\nhad\tO\neverything\tO\nrunning\tT-0\nwith\tO\nall\tO\nmy\tO\nsoftware\tB-aspectTerm\ninstalled\tO\nI\tO\nplugged\tT-1\nin\tT-1\nmy\tO\ndroid\tT-2\nto\tO\nrecharge\tO\nand\tO\nthe\tO\nsystem\tT-3\ncrashed\tO\n.\tO\n\nWhen\tO\nI\tO\nfinally\tO\nhad\tO\neverything\tO\nrunning\tO\nwith\tO\nall\tO\nmy\tO\nsoftware\tO\ninstalled\tT-0\nI\tO\nplugged\tT-1\nin\tO\nmy\tO\ndroid\tT-3\nto\tT-2\nrecharge\tT-4\nand\tO\nthe\tO\nsystem\tB-aspectTerm\ncrashed\tO\n.\tO\n\nOne\tO\nsuggestion\tO\nI\tO\ndo\tO\nhave\tO\n,\tO\nis\tO\nto\tO\nnot\tT-0\nbother\tT-0\ngetting\tT-0\nMicrosoft\tB-aspectTerm\noffice\tI-aspectTerm\nfor\tI-aspectTerm\nthe\tI-aspectTerm\nmac\tI-aspectTerm\nexpecting\tO\nit\tO\nwill\tO\nwork\tT-1\njust\tO\nlike\tO\nyou\tO\nknew\tO\nit\tO\nto\tO\non\tO\na\tO\nPC\tO\n.\tO\n\nPairing\tT-0\nit\tO\nwith\tO\nan\tO\niPhone\tT-1\nis\tO\na\tO\npure\tO\npleasure\tO\n-\tO\ntalk\tO\nabout\tO\npainless\tO\nsyncing\tB-aspectTerm\n-\tO\nused\tO\nto\tO\ntake\tO\nme\tO\nforever\tO\n-\tO\nnow\tO\nit\tO\n's\tO\na\tO\nsnap\tT-2\n.\tO\n\nI\tO\nalso\tO\ngot\tO\nthe\tO\nadded\tO\nbonus\tT-1\nof\tO\na\tO\n30\tB-aspectTerm\n\"\tI-aspectTerm\nHD\tI-aspectTerm\nMonitor\tI-aspectTerm\n,\tO\nwhich\tO\nreally\tT-0\nhelps\tT-0\nto\tT-0\nextend\tO\nmy\tO\nscreen\tO\nand\tO\nkeep\tO\nmy\tO\neyes\tO\nfresh\tO\n!\tO\n\nI\tO\nalso\tO\ngot\tO\nthe\tO\nadded\tO\nbonus\tO\nof\tO\na\tO\n30\tO\n\"\tO\nHD\tT-1\nMonitor\tT-1\n,\tO\nwhich\tO\nreally\tO\nhelps\tO\nto\tO\nextend\tT-0\nmy\tO\nscreen\tB-aspectTerm\nand\tO\nkeep\tO\nmy\tO\neyes\tO\nfresh\tO\n!\tO\n\nThe\tO\nmachine\tT-0\nis\tO\nslow\tO\nto\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nand\tO\noccasionally\tO\ncrashes\tO\ncompletely\tO\n.\tO\n\nAfter\tO\npaying\tT-1\nseveral\tO\nhundred\tO\ndollars\tO\nfor\tO\nthis\tO\nservice\tB-aspectTerm\n,\tO\nit\tO\nis\tO\nfrustrating\tO\nthat\tO\nyou\tO\ncan\tO\nnot\tO\nget\tT-0\nhelp\tT-0\nafter\tO\nhours\tO\n.\tO\n\nI\tO\ndid\tO\nhave\tO\nto\tO\nreplace\tT-1\nthe\tO\nbattery\tB-aspectTerm\nonce\tO\n,\tO\nbut\tO\nthat\tO\nwas\tO\nonly\tO\na\tO\ncouple\tO\nmonths\tO\nago\tO\nand\tO\nit\tT-0\n's\tT-0\nbeen\tT-0\nworking\tT-0\nperfect\tT-0\never\tT-0\nsince\tT-0\n.\tO\n\nI\tO\nlove\tO\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nand\tO\nthe\tO\npreloaded\tT-0\nsoftware\tT-1\n.\tT-1\n\nI\tO\nlove\tO\nthe\tO\noperating\tO\nsystem\tO\nand\tO\nthe\tO\npreloaded\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tT-0\n\nThe\tO\nbest\tO\nthing\tO\nabout\tO\nthis\tO\nlaptop\tT-0\nis\tO\nthe\tO\nprice\tB-aspectTerm\nalong\tO\nwith\tO\nsome\tO\nof\tO\nthe\tO\nnewer\tO\nfeatures\tO\n.\tT-1\n\nThe\tO\nbest\tO\nthing\tO\nabout\tO\nthis\tO\nlaptop\tO\nis\tO\nthe\tO\nprice\tO\nalong\tO\nwith\tO\nsome\tO\nof\tO\nthe\tO\nnewer\tT-0\nfeatures\tB-aspectTerm\n.\tO\n\nAfter\tO\nnumerous\tO\nattempts\tO\nof\tO\ntrying\tT-1\n(\tO\nincluding\tO\nsetting\tT-0\nthe\tO\nclock\tB-aspectTerm\nin\tI-aspectTerm\nBIOS\tI-aspectTerm\nsetup\tI-aspectTerm\ndirectly\tO\n)\tO\n,\tO\nI\tO\ngave\tO\nup(I\tO\nam\tO\na\tO\ntechie\tO\n)\tO\n.\tO\n\nYOU\tO\nWILL\tO\nNOT\tO\nBE\tO\nABLE\tO\nTO\tO\nTALK\tO\nTO\tO\nAN\tO\nAMERICAN\tT-0\nWARRANTY\tB-aspectTerm\nSERVICE\tI-aspectTerm\nIS\tO\nOUT\tO\nOF\tO\nCOUNTRY\tO\n.\tO\n\nbut\tO\nnow\tO\ni\tO\nhave\tO\nrealized\tO\nits\tO\na\tO\nproblem\tT-0\nwith\tT-0\nthis\tO\nbrand\tB-aspectTerm\n.\tO\n\nI\tO\nsent\tO\nit\tO\nback\tO\nto\tO\nToshiba\tT-0\ntwice\tO\nthey\tO\ncovered\tT-1\nit\tO\nunder\tT-3\nthe\tO\nO\tT-2\nwarranty\tB-aspectTerm\n.\tO\n\nAlso\tO\nkinda\tT-2\nloud\tT-1\nwhen\tO\nthe\tO\nfan\tB-aspectTerm\nwas\tT-0\nrunning\tT-0\n.\tO\n\nIn\tO\ndesparation\tO\n,\tO\nI\tO\ncalled\tO\ntheir\tO\nCustomer\tB-aspectTerm\nService\tI-aspectTerm\nnumber\tI-aspectTerm\nand\tO\nwas\tO\ntold\tO\nthat\tO\nmy\tO\nwarranty\tT-1\nhad\tO\nexpired\tT-0\n(\tO\n2\tO\ndays\tO\nold\tO\n)\tO\nand\tO\nthat\tO\nthe\tO\npriviledge\tO\nof\tO\ntalking\tO\nto\tO\na\tO\ntechnician\tO\nwould\tO\ncost\tO\nme\tO\n(\tO\n\"\tO\nhave\tO\nyour\tO\ncredit\tO\ncard\tO\nready\tO\n\"\tO\n)\tO\n.\tO\n\nIn\tO\ndesparation\tO\n,\tO\nI\tO\ncalled\tO\ntheir\tO\nCustomer\tT-1\nService\tT-1\nnumber\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nmy\tO\nwarranty\tB-aspectTerm\nhad\tT-2\nexpired\tT-2\n(\tO\n2\tO\ndays\tO\nold\tO\n)\tO\nand\tO\nthat\tO\nthe\tO\npriviledge\tO\nof\tO\ntalking\tO\nto\tO\na\tO\ntechnician\tT-0\nwould\tO\ncost\tO\nme\tO\n(\tO\n\"\tO\nhave\tO\nyour\tO\ncredit\tO\ncard\tO\nready\tO\n\"\tO\n)\tO\n.\tO\n\nIn\tO\ndesparation\tO\n,\tO\nI\tO\ncalled\tT-0\ntheir\tO\nCustomer\tO\nService\tO\nnumber\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nmy\tO\nwarranty\tT-2\nhad\tO\nexpired\tO\n(\tO\n2\tO\ndays\tO\nold\tO\n)\tO\nand\tO\nthat\tO\nthe\tO\npriviledge\tT-3\nof\tT-3\ntalking\tB-aspectTerm\nto\tI-aspectTerm\na\tI-aspectTerm\ntechnician\tI-aspectTerm\nwould\tT-1\ncost\tT-1\nme\tT-1\n(\tO\n\"\tO\nhave\tO\nyour\tO\ncredit\tO\ncard\tO\nready\tO\n\"\tO\n)\tO\n.\tO\n\nThere\tO\nalso\tO\nseemed\tO\nto\tO\nbe\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\nhard\tB-aspectTerm\ndisc\tI-aspectTerm\nas\tO\ncertain\tO\ntimes\tO\nwindows\tT-0\nloads\tO\nbut\tO\nclaims\tO\nto\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\nfind\tO\nany\tO\ndrivers\tT-1\nor\tO\nfiles\tO\n.\tO\n\nThere\tO\nalso\tO\nseemed\tO\nto\tO\nbe\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\nhard\tO\ndisc\tO\nas\tO\ncertain\tO\ntimes\tT-1\nwindows\tB-aspectTerm\nloads\tT-0\nbut\tO\nclaims\tO\nto\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\nfind\tO\nany\tO\ndrivers\tO\nor\tO\nfiles\tO\n.\tO\n\nThere\tO\nalso\tO\nseemed\tO\nto\tO\nbe\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\nhard\tO\ndisc\tT-2\nas\tO\ncertain\tO\ntimes\tO\nwindows\tT-0\nloads\tO\nbut\tO\nclaims\tO\nto\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\nfind\tT-1\nany\tO\ndrivers\tB-aspectTerm\nor\tO\nfiles\tT-3\n.\tO\n\nDrivers\tB-aspectTerm\nupdated\tT-0\nok\tO\nbut\tO\nthe\tO\nBIOS\tT-1\nupdate\tO\nfroze\tO\nthe\tO\nsystem\tO\nup\tO\nand\tO\nthe\tO\ncomputer\tO\nshut\tO\ndown\tO\n.\tO\n\nDrivers\tO\nupdated\tT-1\nok\tO\nbut\tO\nthe\tO\nBIOS\tB-aspectTerm\nupdate\tI-aspectTerm\nfroze\tT-2\nthe\tT-2\nsystem\tT-2\nup\tT-2\nand\tO\nthe\tO\ncomputer\tT-0\nshut\tT-3\ndown\tT-3\n.\tO\n\nDrivers\tO\nupdated\tO\nok\tO\nbut\tO\nthe\tO\nBIOS\tO\nupdate\tO\nfroze\tT-0\nthe\tO\nsystem\tB-aspectTerm\nup\tT-1\nand\tO\nthe\tO\ncomputer\tO\nshut\tO\ndown\tO\n.\tO\n\nSpent\tT-0\n2\tO\nhours\tO\non\tT-2\nphone\tT-2\nwith\tT-2\nHP\tB-aspectTerm\nTechnical\tI-aspectTerm\nSupport\tI-aspectTerm\n.\tT-1\n\nThe\tO\nkeyboard\tB-aspectTerm\nis\tO\ntoo\tO\nslick\tT-0\n.\tO\n\nNightly\tO\nmy\tO\ncomputer\tO\ndefrags\tT-1\nitself\tO\nand\tO\nruns\tO\na\tO\nvirus\tB-aspectTerm\nscan\tI-aspectTerm\n.\tT-0\n\nIt\tO\n's\tO\nlike\tO\n9\tB-aspectTerm\npunds\tI-aspectTerm\n,\tO\nbut\tO\nif\tO\nyou\tO\ncan\tO\nlook\tT-0\npast\tT-2\nit\tT-1\n,\tO\nit\tO\n's\tO\nGREAT\tO\n!\tO\n\nIt\tO\n's\tO\njust\tO\nas\tO\nfast\tT-1\nwith\tO\none\tO\nprogram\tB-aspectTerm\nopen\tT-0\nas\tO\nit\tO\nis\tO\nwith\tO\nsixteen\tO\nopen\tO\n.\tO\n\nStill\tO\nunder\tO\nwarrenty\tB-aspectTerm\nso\tO\ncalled\tO\nToshiba\tT-1\n,\tO\nno\tO\nhelp\tT-0\nat\tO\nall\tO\n.\tO\n\nI\tO\nwas\tO\nhappy\tO\nwith\tO\nMy\tO\npurchase\tO\nof\tO\na\tO\nToshiba\tO\nSatellite\tO\nL305D\tO\n-\tO\nS5934\tO\nlaptop\tO\nuntil\tO\nit\tO\ncame\tO\ntime\tO\nto\tO\nhave\tO\nit\tO\nrepaired\tT-0\nunder\tO\nthe\tO\nToshiba\tB-aspectTerm\nWarranty\tI-aspectTerm\n.\tO\n\nAmazing\tT-0\nQuality\tB-aspectTerm\n!\tO\n\nThe\tO\nfact\tO\nthat\tO\nyou\tO\ncan\tO\nspend\tO\nover\tO\n$\tO\n100\tO\non\tO\njust\tO\na\tO\nwebcam\tB-aspectTerm\nunderscores\tT-0\nthe\tO\nvalue\tO\nof\tO\nthis\tO\nmachine\tO\n.\tO\n\nThe\tO\nfact\tO\nthat\tO\nyou\tO\ncan\tO\nspend\tO\nover\tO\n$\tO\n100\tO\non\tO\njust\tT-0\na\tO\nwebcam\tT-1\nunderscores\tO\nthe\tO\nvalue\tB-aspectTerm\nof\tO\nthis\tO\nmachine\tT-2\n.\tO\n\nI\tO\nmainly\tO\nuse\tT-1\nit\tT-1\nfor\tT-1\nemail\tO\n,\tO\ninternet\tB-aspectTerm\n,\tO\nand\tO\nmanaging\tT-0\npersonal\tO\nfiles\tO\n(\tO\npics\tO\n,\tO\nvids\tO\n,\tO\netc\tO\n.\tO\n)\tO\n.\tO\n\nI\tO\nmainly\tO\nuse\tO\nit\tO\nfor\tO\nemail\tO\n,\tO\ninternet\tO\n,\tO\nand\tO\nmanaging\tB-aspectTerm\npersonal\tI-aspectTerm\nfiles\tI-aspectTerm\n(\tO\npics\tT-0\n,\tT-0\nvids\tT-0\n,\tT-0\netc\tT-0\n.\tO\n)\tO\n.\tO\n\nA\tO\nmonth\tT-0\nor\tO\nso\tO\nago\tO\n,\tO\nthe\tO\nfreaking\tO\nmotherboard\tB-aspectTerm\njust\tO\ndied\tT-1\n.\tO\n\nThe\tO\nsystem\tB-aspectTerm\nit\tO\ncomes\tO\nwith\tO\ndoes\tO\nnot\tO\nwork\tO\nproperly\tT-0\n,\tO\nso\tO\nwhen\tO\ntrying\tO\nto\tO\nfix\tO\nthe\tO\nproblems\tO\nwith\tO\nit\tO\nit\tO\nstarted\tO\nnot\tO\nworking\tO\nat\tO\nall\tO\n.\tO\n\nThen\tO\nafter\tO\n4\tO\nor\tO\nso\tO\nmonths\tO\nthe\tO\ncharger\tB-aspectTerm\nstopped\tO\nworking\tT-0\nso\tO\nI\tO\nwas\tO\nforced\tO\nto\tO\ngo\tO\nout\tO\nand\tO\nbuy\tO\nnew\tO\nhardware\tT-1\njust\tO\nto\tO\nkeep\tO\nthis\tO\ncomputer\tT-2\nrunning\tO\n.\tO\n\nThen\tO\nafter\tO\n4\tO\nor\tO\nso\tO\nmonths\tO\nthe\tO\ncharger\tT-0\nstopped\tO\nworking\tO\nso\tO\nI\tO\nwas\tO\nforced\tO\nto\tO\ngo\tO\nout\tO\nand\tO\nbuy\tO\nnew\tO\nhardware\tB-aspectTerm\njust\tO\nto\tO\nkeep\tT-1\nthis\tT-1\ncomputer\tT-1\nrunning\tT-1\n.\tO\n\nIf\tO\na\tO\nwebsite\tO\never\tO\nfreezes\tT-1\n(\tO\nwhich\tO\nis\tO\nrare\tO\n)\tO\n,\tO\nits\tO\nreally\tO\neasy\tT-0\nto\tT-0\nforce\tB-aspectTerm\nquit\tI-aspectTerm\n.\tO\n\nIt\tT-1\nrarely\tT-1\nworks\tB-aspectTerm\nand\tO\nwhen\tO\nit\tO\ndoes\tO\nit\tO\n's\tO\nincredibly\tT-0\nslow\tO\n.\tO\n\nI\tO\nalso\tO\nenjoy\tO\nthe\tO\nfact\tO\nthat\tO\nmy\tO\nMacBook\tT-0\nPro\tO\nlaptop\tO\nallows\tO\nme\tO\nto\tO\nrun\tT-1\nWindows\tB-aspectTerm\n7\tI-aspectTerm\non\tO\nit\tO\nby\tO\nusing\tO\nthe\tO\nVMWare\tO\nprogram\tO\n.\tO\n\nI\tO\nalso\tO\nenjoy\tO\nthe\tO\nfact\tO\nthat\tO\nmy\tO\nMacBook\tT-2\nPro\tO\nlaptop\tO\nallows\tO\nme\tO\nto\tO\nrun\tO\nWindows\tT-0\n7\tT-0\non\tO\nit\tO\nby\tO\nusing\tT-1\nthe\tT-1\nVMWare\tB-aspectTerm\nprogram\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tT-1\nto\tT-1\nnavigate\tB-aspectTerm\nthrough\tT-0\nthe\tO\noperating\tO\nsystem\tO\n,\tO\nto\tO\nfind\tO\nfiles\tO\n,\tO\nand\tO\nit\tO\nruns\tO\na\tO\nlot\tO\nfaster\tO\n!\tO\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tO\nto\tO\nnavigate\tT-1\nthrough\tT-1\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n,\tO\nto\tO\nfind\tO\nfiles\tO\n,\tO\nand\tO\nit\tO\nruns\tO\na\tO\nlot\tO\nfaster\tO\n!\tT-0\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tO\nto\tO\nnavigate\tT-0\nthrough\tO\nthe\tO\noperating\tT-1\nsystem\tT-1\n,\tO\nto\tO\nfind\tB-aspectTerm\nfiles\tI-aspectTerm\n,\tO\nand\tO\nit\tO\nruns\tO\na\tO\nlot\tO\nfaster\tO\n!\tO\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tT-1\nto\tO\nnavigate\tT-2\nthrough\tO\nthe\tO\noperating\tT-3\nsystem\tO\n,\tO\nto\tO\nfind\tO\nfiles\tO\n,\tO\nand\tO\nit\tO\nruns\tB-aspectTerm\na\tT-0\nlot\tT-0\nfaster\tT-0\n!\tT-0\n\nPurchased\tO\na\tO\nToshiba\tT-0\nLap\tT-1\ntop\tT-1\nit\tO\nworked\tO\ngood\tO\nuntil\tO\njust\tO\nafter\tT-2\nthe\tO\nwarrenty\tB-aspectTerm\nwent\tO\nout\tO\n.\tO\n\nI\tO\nwanted\tO\nto\tO\npurchase\tO\nthe\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\nand\tO\nthey\tO\nrefused\tT-1\n,\tO\nbecause\tO\nthey\tO\nknew\tO\nit\tO\nwas\tO\ntrouble\tT-0\n.\tO\n\nWe\tO\nupgraded\tO\nthe\tO\nmemory\tB-aspectTerm\nto\tO\nfour\tO\ngigabytes\tT-0\nin\tO\norder\tO\nto\tO\ntake\tO\nadvantage\tO\nof\tO\nthe\tO\nperformace\tO\nincrease\tO\nin\tO\nspeed\tO\n.\tT-1\n\nWe\tO\nupgraded\tT-0\nthe\tO\nmemory\tO\nto\tO\nfour\tO\ngigabytes\tT-1\nin\tO\norder\tO\nto\tO\ntake\tO\nadvantage\tO\nof\tO\nthe\tO\nperformace\tB-aspectTerm\nincrease\tO\nin\tO\nspeed\tO\n.\tO\n\nWe\tO\nupgraded\tT-0\nthe\tO\nmemory\tT-2\nto\tO\nfour\tO\ngigabytes\tT-1\nin\tO\norder\tO\nto\tO\ntake\tO\nadvantage\tO\nof\tO\nthe\tO\nperformace\tT-3\nincrease\tO\nin\tO\nspeed\tB-aspectTerm\n.\tO\n\nThe\tO\nreality\tO\nwas\tO\n,\tO\nit\tO\nheated\tT-1\nup\tT-1\nvery\tO\nquickly\tO\n,\tO\nand\tO\ntook\tO\nway\tO\ntoo\tO\nlong\tT-0\nto\tO\ndo\tO\nsimple\tO\nthings\tO\n,\tO\nlike\tO\nopening\tB-aspectTerm\nmy\tI-aspectTerm\nDocuments\tI-aspectTerm\nfolder\tI-aspectTerm\n.\tO\n\nI\tO\nhad\tO\nalways\tO\nused\tO\nPCs\tO\nand\tO\nbeen\tO\nconstantly\tO\nfrustrated\tO\nby\tO\nthe\tO\ncrashing\tT-1\nand\tO\nthe\tO\npoorly\tT-2\ndesigned\tT-2\noperating\tB-aspectTerm\nsystems\tI-aspectTerm\nthat\tT-0\nwere\tT-0\nnever\tT-0\nvery\tT-0\nintuitive\tT-0\n.\tO\n\nThen\tO\n,\tO\nwithin\tO\n5\tO\nmonths\tO\n,\tO\nthe\tO\ncharger\tB-aspectTerm\ncrapped\tT-0\nout\tO\non\tO\nme\tO\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\nhave\tO\na\tO\niphone\tO\nor\tO\nipod\tO\ntouch\tO\nyou\tO\ncan\tO\nconnect\tO\nand\tO\ndownload\tT-0\nsongs\tO\nto\tO\nit\tO\nat\tO\nhigh\tT-1\nspeed\tB-aspectTerm\n.\tO\n\nI\tT-0\nlove\tT-0\nthe\tT-0\nglass\tB-aspectTerm\ntouchpad\tI-aspectTerm\n.\tO\n\nÂ\tT-0\nI\tO\ncontinued\tO\nto\tO\ntake\tO\nthe\tO\ncomputer\tO\nin\tO\nAGAIN\tO\nand\tO\nthey\tO\nreplaced\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nmother\tO\nboard\tO\nyet\tO\nagain\tO\n.\tT-0\n\nÂ\tT-0\nI\tO\ncontinued\tO\nto\tO\ntake\tO\nthe\tO\ncomputer\tO\nin\tO\nAGAIN\tO\nand\tO\nthey\tO\nreplaced\tO\nthe\tO\nhard\tO\ndrive\tO\nand\tO\nmother\tB-aspectTerm\nboard\tI-aspectTerm\nyet\tO\nagain\tO\n.\tT-0\n\nI\tT-0\nam\tT-0\nusing\tT-0\nthe\tT-0\nexternal\tB-aspectTerm\nspeaker-\tI-aspectTerm\nsound\tT-1\nis\tO\ngood\tO\n.\tO\n\nI\tO\nam\tO\nusing\tO\nthe\tO\nexternal\tT-0\nspeaker-\tT-1\nsound\tB-aspectTerm\nis\tO\ngood\tT-2\n.\tT-1\n\nstill\tO\ntesting\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nas\tO\ni\tO\nthought\tO\nit\tO\nwould\tO\nbe\tO\nbetter\tO\n,\tO\nbut\tO\nam\tO\nvery\tO\nhappy\tO\nwith\tO\nthe\tO\nupgrade\tT-0\n.\tO\n\nThen\tO\nHP\tO\nsends\tO\nit\tO\nback\tO\nto\tO\nme\tO\nwith\tO\nthe\tO\nhardware\tB-aspectTerm\nscrewed\tT-0\nup\tT-0\n,\tO\nnot\tO\nable\tO\nto\tO\nconnect\tT-1\n.\tO\n\nOh\tO\nyeah\tO\n,\tO\ndo\tO\nn't\tO\nforget\tO\nthe\tO\nexpensive\tO\nshipping\tB-aspectTerm\nto\tO\nand\tO\nfrom\tO\nHP\tT-0\n.\tO\n\nEverything\tO\nis\tO\nso\tO\neasy\tT-1\nto\tO\nuse\tB-aspectTerm\n,\tO\nMac\tO\nsoftware\tO\nis\tO\njust\tO\nso\tO\nmuch\tO\nsimpler\tT-0\nthan\tO\nMicrosoft\tO\nsoftware\tO\n.\tO\n\nEverything\tO\nis\tO\nso\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nMac\tB-aspectTerm\nsoftware\tI-aspectTerm\nis\tT-1\njust\tT-1\nso\tT-1\nmuch\tT-1\nsimpler\tT-1\nthan\tT-1\nMicrosoft\tT-1\nsoftware\tT-1\n.\tT-0\n\nEverything\tO\nis\tO\nso\tO\neasy\tO\nto\tO\nuse\tT-0\n,\tO\nMac\tT-1\nsoftware\tT-2\nis\tO\njust\tO\nso\tO\nmuch\tO\nsimpler\tT-3\nthan\tO\nMicrosoft\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\ndo\tO\na\tO\nlot\tO\nof\tO\nwriting\tO\n,\tO\nediting\tB-aspectTerm\nis\tO\na\tO\nproblem\tT-0\nsince\tO\nthere\tO\nis\tO\nno\tO\nO\tO\nforward\tO\ndelete\tO\nI-aspectTerm\tO\nkey\tO\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\ndo\tO\na\tO\nlot\tO\nof\tO\nwriting\tO\n,\tO\nediting\tT-1\nis\tO\na\tO\nproblem\tO\nsince\tO\nthere\tO\nis\tO\nno\tO\nO\tT-0\nforward\tT-0\ndelete\tB-aspectTerm\nI-aspectTerm\tI-aspectTerm\nkey\tI-aspectTerm\n.\tO\n\nIts\tT-0\nease\tT-0\nof\tT-0\nuse\tB-aspectTerm\nand\tO\nthe\tO\ntop\tT-1\nservice\tO\nfrom\tO\nApple-\tO\nbe\tO\nit\tO\ntheir\tO\nphone\tO\nassistance\tO\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tO\nbar-\tO\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tO\n\nIts\tO\nease\tO\nof\tO\nuse\tO\nand\tO\nthe\tO\ntop\tO\nservice\tB-aspectTerm\nfrom\tO\nApple-\tT-0\nbe\tO\nit\tO\ntheir\tO\nphone\tO\nassistance\tO\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tO\nbar-\tO\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tT-0\n\nIts\tO\nease\tO\nof\tO\nuse\tO\nand\tO\nthe\tO\ntop\tT-1\nservice\tT-1\nfrom\tO\nApple-\tO\nbe\tO\nit\tO\ntheir\tO\nphone\tB-aspectTerm\nassistance\tI-aspectTerm\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tO\nbar-\tO\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tT-0\n\nIts\tO\nease\tO\nof\tO\nuse\tO\nand\tO\nthe\tO\ntop\tO\nservice\tO\nfrom\tO\nApple-\tT-0\nbe\tO\nit\tO\ntheir\tO\nphone\tT-1\nassistance\tO\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tB-aspectTerm\nbar-\tI-aspectTerm\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tT-0\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tT-0\nbrowsing\tT-0\nand\tT-0\nword\tT-0\nediting\tT-0\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tT-1\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tO\nand\tO\nmovie\tO\nplaying\tO\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tO\nlife\tO\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-1\nlife\tT-1\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\nand\tO\nword\tT-0\nediting\tT-0\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tO\nand\tO\nmovie\tO\nplaying\tO\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tO\nlife\tO\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-0\nlife\tO\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tO\nbrowsing\tO\nand\tO\nword\tB-aspectTerm\nediting\tI-aspectTerm\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tT-1\nand\tT-1\nmovie\tT-1\nplaying\tT-1\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tO\nlife\tO\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-3\nlife\tT-3\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tT-1\nbrowsing\tT-1\nand\tO\nword\tT-2\nediting\tT-2\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tB-aspectTerm\nand\tO\nmovie\tO\nplaying\tO\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tT-0\nlife\tT-0\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-1\nlife\tO\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tO\nbrowsing\tO\nand\tO\nword\tO\nediting\tO\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tT-2\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tT-3\nand\tO\nmovie\tB-aspectTerm\nplaying\tI-aspectTerm\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tT-0\nlife\tT-0\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-2\nlife\tO\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tO\nbrowsing\tT-3\nand\tO\nword\tO\nediting\tO\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tT-0\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tT-1\nand\tO\nmovie\tO\nplaying\tO\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nAcer\tO\nhas\tO\nset\tO\nme\tO\nup\tO\nwith\tO\nFREE\tT-1\nrecovery\tB-aspectTerm\ndiscs\tI-aspectTerm\n,\tO\nwhen\tT-0\nthey\tT-0\nare\tT-0\navailable\tT-0\nsince\tO\nI\tO\nasked\tT-2\n.\tO\n\nI\tO\nalso\tO\npurchased\tT-1\nOffice\tB-aspectTerm\nMax\tI-aspectTerm\n's\tI-aspectTerm\n\"\tI-aspectTerm\nMax\tI-aspectTerm\nAssurance\tI-aspectTerm\n\"\tI-aspectTerm\nwith\tO\nthe\tO\n\"\tO\nno\tT-2\nlemon\tT-2\n\"\tO\nclause\tT-3\n.\tT-0\n\nI\tO\neventually\tO\ndid\tT-2\nthe\tT-2\nmigration\tT-2\nfrom\tO\nmy\tO\niMac\tB-aspectTerm\nbackup\tI-aspectTerm\ndisc\tI-aspectTerm\nwhich\tT-3\nuses\tT-3\nUSB\tT-3\n.\tT-0\n\nI\tO\neventually\tO\ndid\tO\nthe\tO\nmigration\tT-0\nfrom\tO\nmy\tO\niMac\tT-1\nbackup\tT-2\ndisc\tT-3\nwhich\tT-3\nuses\tT-3\nUSB\tB-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nseems\tO\nto\tO\nbe\tO\nvery\tO\ngood\tT-0\n,\tO\nand\tO\nhave\tO\nhad\tO\nno\tO\nissues\tO\nwith\tO\nit\tO\n.\tO\n\nEnabling\tT-0\nthe\tO\nbattery\tB-aspectTerm\ntimer\tI-aspectTerm\nis\tO\nuseless\tT-1\n.\tO\n\nTemperatures\tB-aspectTerm\non\tO\nthe\tO\noutside\tT-1\nwere\tO\nalright\tO\nbut\tO\ni\tO\ndid\tO\nnot\tO\ntrack\tO\nin\tO\nCore\tO\nProcessing\tO\nUnit\tO\ntemperatures\tT-0\n.\tO\n\nTemperatures\tO\non\tO\nthe\tO\noutside\tO\nwere\tO\nalright\tO\nbut\tO\ni\tO\ndid\tO\nnot\tO\ntrack\tT-1\nin\tT-1\nCore\tB-aspectTerm\nProcessing\tI-aspectTerm\nUnit\tI-aspectTerm\ntemperatures\tI-aspectTerm\n.\tT-0\n\nGoing\tO\nto\tO\nbring\tO\nit\tO\nto\tO\nservice\tB-aspectTerm\ntoday\tO\n.\tT-0\n\nThere\tO\nis\tO\nno\tO\nneed\tO\nto\tO\npurchase\tT-1\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\nfor\tI-aspectTerm\nMac\tI-aspectTerm\n,\tO\nwhich\tO\nsaves\tT-0\nme\tO\na\tO\nlot\tO\nof\tO\ntime\tO\nand\tO\nmoney\tO\n.\tO\n\nBut\tO\nwe\tO\nhad\tO\npaid\tT-1\nfor\tO\nbluetooth\tB-aspectTerm\n,\tO\nand\tO\nthere\tO\nwas\tO\nnone\tT-2\n.\tT-0\n\nSo\tO\n,\tO\nI\tO\npaid\tT-0\na\tO\nvisit\tO\nto\tO\nLG\tB-aspectTerm\nnotebook\tI-aspectTerm\nservice\tI-aspectTerm\ncenter\tI-aspectTerm\nat\tO\nAlexandra\tO\nRoad\tO\n,\tO\nhoping\tO\nthey\tO\ncan\tO\nmake\tO\nthe\tO\nhinge\tT-1\ntighter\tT-1\n.\tO\n\nSo\tO\n,\tO\nI\tO\npaid\tO\na\tO\nvisit\tO\nto\tO\nLG\tO\nnotebook\tT-0\nservice\tT-0\ncenter\tT-0\nat\tO\nAlexandra\tO\nRoad\tO\n,\tO\nhoping\tO\nthey\tO\ncan\tO\nmake\tO\nthe\tO\nhinge\tB-aspectTerm\ntighter\tT-1\n.\tO\n\nIt\tO\nis\tO\nalways\tO\nreliable\tT-0\n,\tO\nnever\tT-1\nbugged\tT-2\nand\tO\nresponds\tB-aspectTerm\nwell\tO\n.\tO\n\nAfter\tO\nabout\tO\na\tO\nweek\tO\nI\tO\nfinally\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nthe\tO\nmotherboard\tB-aspectTerm\nhad\tO\nfailed\tT-0\nand\tO\nso\tO\nthey\tO\ninstalled\tT-1\na\tO\nnew\tO\nmotherboard\tT-2\n.\tO\n\nAfter\tO\nabout\tO\na\tO\nweek\tO\nI\tO\nfinally\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nthe\tO\nmotherboard\tT-0\nhad\tO\nfailed\tT-2\nand\tO\nso\tO\nthey\tO\ninstalled\tT-1\na\tO\nnew\tO\nmotherboard\tB-aspectTerm\n.\tO\n\nthey\tO\nhad\tO\nto\tO\nreplace\tO\nthe\tO\nmotherboard\tB-aspectTerm\nin\tO\nApril\tT-0\n\nYes\tO\n,\tO\nthe\tO\ncomputer\tO\nwas\tO\nlight\tO\nweight\tO\n,\tO\nless\tO\nexpensive\tO\nthan\tO\nthe\tO\naverage\tT-1\nlaptop\tO\n,\tO\nand\tO\nwas\tO\npretty\tT-0\nself\tO\nexplantory\tO\nin\tO\nuse\tB-aspectTerm\n.\tO\n\nAlso\tO\n,\tO\nif\tO\nyou\tO\nneed\tO\nto\tO\ntalk\tO\nto\tO\na\tO\nrepresentive\tB-aspectTerm\nat\tI-aspectTerm\nMicrosoft\tI-aspectTerm\n,\tO\nthere\tO\nis\tO\na\tO\ncharge\tO\n,\tO\nwhich\tO\nI\tO\nbelieve\tT-0\nis\tO\nrobbery\tO\n,\tO\nsince\tO\nyou\tO\nare\tO\ncharged\tO\nenormous\tO\namounts\tO\nfor\tO\na\tO\nvery\tO\nbadly\tO\ndesigned\tT-1\nsystem\tO\n,\tO\nwhich\tO\nmost\tO\npeople\tO\nwould\tO\nhave\tO\nwent\tO\nwith\tO\nXP\tO\nif\tO\nthey\tO\ncould\tO\n.\tO\n\nAlso\tO\n,\tO\nif\tO\nyou\tO\nneed\tO\nto\tO\ntalk\tO\nto\tO\na\tO\nrepresentive\tO\nat\tO\nMicrosoft\tT-0\n,\tO\nthere\tO\nis\tO\na\tO\ncharge\tO\n,\tO\nwhich\tO\nI\tO\nbelieve\tO\nis\tO\nrobbery\tO\n,\tO\nsince\tO\nyou\tO\nare\tO\ncharged\tT-1\nenormous\tT-1\namounts\tT-1\nfor\tO\na\tO\nvery\tO\nbadly\tO\ndesigned\tT-2\nsystem\tB-aspectTerm\n,\tO\nwhich\tO\nmost\tO\npeople\tO\nwould\tO\nhave\tO\nwent\tO\nwith\tO\nXP\tO\nif\tO\nthey\tO\ncould\tO\n.\tO\n\nAlso\tO\n,\tO\nif\tO\nyou\tO\nneed\tO\nto\tO\ntalk\tO\nto\tO\na\tO\nrepresentive\tO\nat\tO\nMicrosoft\tT-0\n,\tO\nthere\tO\nis\tO\na\tO\ncharge\tO\n,\tO\nwhich\tO\nI\tO\nbelieve\tO\nis\tO\nrobbery\tO\n,\tO\nsince\tO\nyou\tO\nare\tO\ncharged\tO\nenormous\tO\namounts\tO\nfor\tO\na\tO\nvery\tO\nbadly\tO\ndesigned\tO\nsystem\tT-1\n,\tO\nwhich\tO\nmost\tO\npeople\tO\nwould\tO\nhave\tO\nwent\tO\nwith\tO\nXP\tB-aspectTerm\nif\tO\nthey\tO\ncould\tO\n.\tO\n\nI\tO\nlove\tT-1\nWIndows\tB-aspectTerm\n7\tI-aspectTerm\nwhich\tT-0\nis\tO\na\tO\nvast\tO\nimprovment\tT-2\nover\tO\nVista\tO\n.\tO\n\nI\tO\nlove\tO\nWIndows\tO\n7\tO\nwhich\tO\nis\tO\na\tO\nvast\tT-1\nimprovment\tT-1\nover\tO\nVista\tB-aspectTerm\n.\tT-0\n\nKeyboard\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nvery\tO\nquiet\tT-0\nfor\tO\nall\tO\nthe\tO\ntyping\tT-1\nthat\tO\nI\tO\ndo\tO\n.\tO\n\nDell\tB-aspectTerm\n's\tI-aspectTerm\ncustomer\tI-aspectTerm\ndisservice\tI-aspectTerm\nis\tO\nan\tO\ninsult\tO\nto\tO\nit\tO\n's\tO\ncustomers\tT-1\nwho\tO\npay\tO\ngood\tO\nmoney\tO\nfor\tO\nshoddy\tT-0\nproducts\tT-2\n.\tO\n\nIt\tO\nhad\tO\na\tO\ncooling\tT-0\nsystem\tO\nmalfunction\tT-1\nafter\tO\n10\tO\nminutes\tO\nof\tO\ngeneral\tO\nuse\tB-aspectTerm\n,\tO\nand\tO\nwould\tO\nnot\tO\nmove\tO\npast\tO\nthis\tO\nerror\tT-2\n.\tO\n\nI\tO\ncan\tO\nrender\tO\nAVCHD\tO\nmovies\tO\nwith\tO\nlittle\tT-0\neffort\tO\n,\tO\nwhich\tO\nwas\tO\na\tO\nproblem\tO\nfor\tO\nmost\tO\npc\tO\n's\tO\nunless\tO\nyou\tO\nhad\tO\na\tO\nquad\tB-aspectTerm\ncore\tI-aspectTerm\nI7\tI-aspectTerm\n.\tO\n\nAfter\tO\ntalking\tT-0\nit\tT-0\nover\tT-0\nwith\tO\nthe\tO\nvery\tO\nknowledgeable\tO\nsales\tB-aspectTerm\nassociate\tI-aspectTerm\n,\tO\nI\tO\nchose\tO\nthe\tO\nMacBook\tO\nPro\tO\nover\tO\nthe\tO\nwhite\tO\nMacBook\tO\n.\tO\n\nIf\tO\nyou\tO\nreally\tO\nwant\tO\na\tO\nbang\tO\n-\tO\nup\tO\nsystem\tB-aspectTerm\nand\tO\ndo\tO\nn't\tO\nneed\tO\nto\tO\nrun\tO\nWindows\tT-0\napplications\tT-1\n,\tO\ngo\tO\nwith\tO\nan\tO\nApple\tT-2\n;\tO\n\nIf\tO\nyou\tO\nreally\tO\nwant\tO\na\tO\nbang\tO\n-\tO\nup\tO\nsystem\tO\nand\tO\ndo\tO\nn't\tO\nneed\tO\nto\tO\nrun\tT-0\nWindows\tB-aspectTerm\napplications\tI-aspectTerm\n,\tO\ngo\tO\nwith\tO\nan\tO\nApple\tO\n;\tO\n\nYou\tO\nwo\tO\nn't\tO\nhave\tO\nto\tO\nspend\tO\ngobs\tO\nof\tO\nmoney\tO\non\tO\nsome\tO\ninefficient\tT-2\nvirus\tB-aspectTerm\nprogram\tI-aspectTerm\nthat\tO\nneeds\tT-3\nto\tT-3\nbe\tT-3\nupdated\tT-3\nevery\tO\nmonth\tO\nand\tO\nthat\tO\nconstantly\tO\ndrains\tT-1\nyour\tO\nwallet\tO\n.\tO\n\nIt\tT-1\nweighed\tB-aspectTerm\nlike\tO\nseven\tO\npounds\tO\nor\tO\nsomething\tT-0\nlike\tO\nthat\tO\n.\tO\n\nIt\tO\nweighed\tT-0\nlike\tO\nseven\tB-aspectTerm\npounds\tI-aspectTerm\nor\tO\nsomething\tO\nlike\tO\nthat\tO\n.\tO\n\nYou\tO\nmay\tO\nneed\tT-1\nto\tO\nspecial\tT-0\norder\tO\na\tO\nbag\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\ncolor\tB-aspectTerm\nis\tT-1\neven\tT-0\ncool\tT-2\n.\tO\n\nkeys\tB-aspectTerm\nare\tO\nall\tO\nin\tO\nweird\tT-0\nplaces\tT-0\nand\tO\nis\tO\nway\tO\ntoo\tO\nlarge\tT-1\nfor\tO\nthe\tO\nway\tO\nit\tO\nis\tO\ndesigned\tT-2\n.\tO\n\nkeys\tO\nare\tO\nall\tO\nin\tO\nweird\tO\nplaces\tO\nand\tO\nis\tO\nway\tO\ntoo\tO\nlarge\tT-1\nfor\tO\nthe\tO\nway\tT-0\nit\tT-0\nis\tT-0\ndesigned\tB-aspectTerm\n.\tO\n\nYes\tO\n,\tO\na\tO\nMac\tO\nis\tO\nmuch\tO\nmore\tO\nmoney\tO\nthan\tO\nthe\tO\naverage\tO\nlaptop\tO\nout\tO\nthere\tO\n,\tO\nbut\tO\nthere\tO\nis\tO\nno\tO\ncomparison\tT-0\nin\tO\nstyle\tB-aspectTerm\n,\tO\nspeed\tO\nand\tO\njust\tO\ncool\tO\nfactor\tO\n.\tO\n\nYes\tO\n,\tO\na\tO\nMac\tO\nis\tO\nmuch\tO\nmore\tO\nmoney\tO\nthan\tO\nthe\tO\naverage\tO\nlaptop\tO\nout\tO\nthere\tO\n,\tO\nbut\tO\nthere\tO\nis\tO\nno\tO\ncomparison\tT-0\nin\tO\nstyle\tO\n,\tO\nspeed\tB-aspectTerm\nand\tO\njust\tO\ncool\tO\nfactor\tO\n.\tO\n\nThe\tT-0\nkeyboard\tB-aspectTerm\nfeels\tO\ngood\tO\nand\tO\nI\tO\ntype\tT-1\njust\tT-1\nfine\tT-1\non\tT-1\nit\tO\n.\tO\n\nI\tO\nthought\tO\nthe\tO\nwhite\tO\nMac\tO\ncomputers\tO\nlooked\tT-0\ndirty\tO\ntoo\tO\nquicly\tO\nwhere\tO\nyou\tO\nuse\tO\nthe\tO\nmousepad\tB-aspectTerm\nand\tO\nwhere\tO\nyou\tO\nplace\tO\nyour\tO\nhands\tO\nwhen\tO\ntyping\tO\n.\tO\n\nAnd\tO\nnot\tO\nto\tO\nmention\tO\nafter\tO\nusing\tO\nit\tO\nfor\tO\na\tO\nfew\tO\nmonths\tO\nor\tO\nso\tO\n,\tO\nthe\tO\nbattery\tB-aspectTerm\nwill\tO\nslowly\tO\nless\tO\nand\tO\nless\tO\nhold\tO\na\tO\ncharge\tO\nuntil\tO\nyou\tO\nca\tO\nn't\tO\nleave\tO\nit\tO\nunplugged\tT-0\nfor\tO\nmore\tO\nthan\tO\n5\tO\nminutes\tT-2\nwithout\tO\nthe\tO\nthing\tO\ndying\tT-1\n.\tO\n\nBEST\tO\nBUY\tO\n-\tO\n5\tO\nSTARS\tO\n+\tO\n+\tO\n+\tO\n(\tO\nsales\tB-aspectTerm\n,\tO\nservice\tO\n,\tO\nrespect\tO\nfor\tO\nold\tO\nmen\tO\nwho\tO\nare\tO\nn't\tO\nfamiliar\tT-0\nwith\tO\nthe\tO\ntechnology\tO\n)\tO\nDELL\tO\nCOMPUTERS\tT-1\n-\tO\n3\tO\nstars\tO\nDELL\tO\nSUPPORT\tT-2\n-\tO\nowes\tO\na\tO\nme\tO\na\tO\ncouple\tO\n\nBEST\tO\nBUY\tO\n-\tO\n5\tO\nSTARS\tO\n+\tO\n+\tO\n+\tO\n(\tO\nsales\tO\n,\tO\nservice\tB-aspectTerm\n,\tO\nrespect\tT-0\nfor\tO\nold\tO\nmen\tO\nwho\tO\nare\tO\nn't\tO\nfamiliar\tO\nwith\tO\nthe\tO\ntechnology\tO\n)\tO\nDELL\tO\nCOMPUTERS\tO\n-\tO\n3\tO\nstars\tO\nDELL\tO\nSUPPORT\tO\n-\tO\nowes\tO\na\tO\nme\tO\na\tO\ncouple\tO\n\nBEST\tO\nBUY\tO\n-\tO\n5\tO\nSTARS\tO\n+\tO\n+\tO\n+\tO\n(\tO\nsales\tO\n,\tO\nservice\tO\n,\tO\nrespect\tO\nfor\tO\nold\tO\nmen\tO\nwho\tO\nare\tO\nn't\tO\nfamiliar\tT-1\nwith\tO\nthe\tO\ntechnology\tO\n)\tO\nDELL\tO\nCOMPUTERS\tO\n-\tO\n3\tT-0\nstars\tT-0\nDELL\tB-aspectTerm\nSUPPORT\tI-aspectTerm\n-\tO\nowes\tO\na\tO\nme\tO\na\tO\ncouple\tO\n\nno\tO\ncomplaints\tO\nwith\tO\ntheir\tO\ndesktop\tT-1\n,\tO\nand\tO\nmaybe\tO\nbecause\tO\nit\tO\njust\tO\nsits\tO\non\tO\nyour\tO\ndesktop\tT-2\n,\tO\nand\tO\nyou\tO\ndo\tO\nn't\tO\ncarry\tO\nit\tO\naround\tO\n,\tO\nwhich\tO\ncould\tO\njar\tT-0\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n,\tO\nor\tO\nthe\tO\nmotherboard\tO\n.\tO\n\nno\tO\ncomplaints\tO\nwith\tO\ntheir\tO\ndesktop\tT-0\n,\tO\nand\tO\nmaybe\tO\nbecause\tO\nit\tO\njust\tO\nsits\tO\non\tO\nyour\tO\ndesktop\tT-1\n,\tO\nand\tO\nyou\tO\ndo\tO\nn't\tO\ncarry\tO\nit\tO\naround\tO\n,\tO\nwhich\tO\ncould\tO\njar\tO\nthe\tO\nhard\tT-2\ndrive\tT-2\n,\tO\nor\tO\nthe\tO\nmotherboard\tB-aspectTerm\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tB-aspectTerm\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tO\nup\tO\nfor\tO\nit\tO\nin\tO\nspeed\tO\n,\tO\nconstruction\tO\nquality\tT-0\n,\tO\nand\tO\nlongevity\tO\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tO\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tO\nup\tO\nfor\tO\nit\tO\nin\tO\nspeed\tB-aspectTerm\n,\tO\nconstruction\tO\nquality\tT-0\n,\tO\nand\tO\nlongevity\tO\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tO\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tT-0\nup\tO\nfor\tO\nit\tO\nin\tO\nspeed\tT-1\n,\tO\nconstruction\tB-aspectTerm\nquality\tI-aspectTerm\n,\tO\nand\tO\nlongevity\tO\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tO\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tT-0\nup\tT-0\nfor\tT-0\nit\tT-0\nin\tT-0\nspeed\tT-1\n,\tT-1\nconstruction\tT-1\nquality\tT-1\n,\tO\nand\tO\nlongevity\tB-aspectTerm\n.\tO\n\nSince\tO\nI\tO\nkeyboard\tT-0\nover\tO\n100\tO\nwpm\tO\n,\tO\nI\tO\nlook\tO\nfor\tO\na\tO\nunit\tO\nthat\tO\nhas\tO\na\tO\ncomfortble\tT-3\nkeyboard\tB-aspectTerm\n(\tO\nno\tO\nkeys\tT-1\nsticking\tO\nor\tO\nlagging\tO\n,\tO\nstrange\tO\nconfiguration\tT-2\nof\tO\n\"\tO\nextra\tO\nkey\tO\n\"\tO\n,\tO\netc\tO\n.\tO\n\nSince\tO\nI\tO\nkeyboard\tT-0\nover\tO\n100\tO\nwpm\tO\n,\tO\nI\tO\nlook\tO\nfor\tO\na\tO\nunit\tO\nthat\tO\nhas\tO\na\tO\ncomfortble\tO\nkeyboard\tT-1\n(\tO\nno\tO\nkeys\tB-aspectTerm\nsticking\tO\nor\tO\nlagging\tO\n,\tO\nstrange\tO\nconfiguration\tT-2\nof\tO\n\"\tO\nextra\tO\nkey\tO\n\"\tO\n,\tO\netc\tO\n.\tO\n\nSince\tO\nI\tO\nkeyboard\tO\nover\tO\n100\tO\nwpm\tT-1\n,\tO\nI\tO\nlook\tO\nfor\tO\na\tO\nunit\tO\nthat\tO\nhas\tO\na\tO\ncomfortble\tO\nkeyboard\tT-0\n(\tO\nno\tO\nkeys\tO\nsticking\tO\nor\tO\nlagging\tO\n,\tO\nstrange\tO\nconfiguration\tB-aspectTerm\nof\tI-aspectTerm\n\"\tI-aspectTerm\nextra\tI-aspectTerm\nkey\tI-aspectTerm\n\"\tI-aspectTerm\n,\tO\netc\tO\n.\tO\n\n)\tO\nI\tO\nalso\tO\ntried\tO\nthe\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\nand\tO\ncompared\tO\nit\tO\nto\tO\nother\tO\nnetbooks\tT-0\nin\tO\nthe\tO\nstore\tO\n.\tO\n\nIt\tO\nabsolutely\tO\nis\tO\nmore\tO\nexpensive\tO\nthan\tO\nmost\tO\nPC\tO\nlaptops\tT-0\n,\tO\nbut\tO\nthe\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\n,\tO\nsecurity\tT-1\n,\tO\nand\tO\nminimal\tO\nproblems\tO\nthat\tO\nhave\tO\narisen\tO\nmake\tO\nit\tO\nwell\tO\nworth\tO\nthe\tO\npricetag\tO\n.\tO\n\nIt\tO\nabsolutely\tO\nis\tO\nmore\tO\nexpensive\tO\nthan\tO\nmost\tO\nPC\tT-0\nlaptops\tT-3\n,\tO\nbut\tO\nthe\tO\nease\tT-1\nof\tT-1\nuse\tT-1\n,\tO\nsecurity\tB-aspectTerm\n,\tO\nand\tO\nminimal\tT-2\nproblems\tT-2\nthat\tO\nhave\tO\narisen\tO\nmake\tO\nit\tO\nwell\tO\nworth\tO\nthe\tO\npricetag\tO\n.\tO\n\nIt\tO\nabsolutely\tO\nis\tO\nmore\tO\nexpensive\tO\nthan\tO\nmost\tO\nPC\tT-0\nlaptops\tT-0\n,\tO\nbut\tO\nthe\tO\nease\tO\nof\tO\nuse\tO\n,\tO\nsecurity\tT-1\n,\tO\nand\tO\nminimal\tO\nproblems\tO\nthat\tO\nhave\tO\narisen\tO\nmake\tO\nit\tO\nwell\tO\nworth\tO\nthe\tO\npricetag\tB-aspectTerm\n.\tO\n\nÂ\tO\nIt\tO\ngets\tO\nstuck\tO\nall\tO\nof\tO\nthe\tO\ntime\tO\nyou\tO\nuse\tB-aspectTerm\nit\tO\n,\tO\nand\tO\nyou\tO\nhave\tO\nto\tO\nkeep\tO\ntapping\tT-1\non\tO\nit\tO\nto\tO\nget\tO\nit\tO\nto\tO\nwork\tO\n.\tT-0\n\nÂ\tO\nIt\tO\ngets\tO\nstuck\tO\nall\tO\nof\tO\nthe\tO\ntime\tO\nyou\tO\nuse\tO\nit\tT-0\n,\tT-0\nand\tT-0\nyou\tO\nhave\tO\nto\tO\nkeep\tO\ntapping\tO\non\tT-1\nit\tT-1\nto\tT-1\nget\tO\nit\tO\nto\tO\nwork\tB-aspectTerm\n.\tO\n\nlots\tT-0\nof\tO\npreloaded\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nI\tO\nwish\tO\nit\tO\nhad\tT-1\na\tT-1\nwebcam\tB-aspectTerm\nthough\tT-0\n,\tO\nthen\tO\nit\tO\nwould\tO\nbe\tO\nperfect\tO\n!\tO\n\nMy\tO\nfavorite\tO\npart\tO\nof\tO\nthis\tO\ncomputer\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\na\tO\nvga\tB-aspectTerm\nport\tI-aspectTerm\nso\tO\nI\tO\ncan\tO\nconnect\tT-1\nit\tO\nto\tT-2\na\tO\nbigger\tT-0\nscreen\tO\n.\tO\n\nMy\tO\nfavorite\tO\npart\tO\nof\tO\nthis\tO\ncomputer\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\na\tO\nvga\tO\nport\tO\nso\tO\nI\tO\ncan\tO\nconnect\tT-0\nit\tO\nto\tO\na\tO\nbigger\tO\nscreen\tB-aspectTerm\n.\tO\n\nAnother\tO\nthing\tO\nI\tO\nmight\tO\nadd\tT-0\nis\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nexcellent\tT-1\n.\tO\n\nOne\tO\ndrawback\tO\n,\tO\nI\tO\nwish\tO\nthe\tO\nkeys\tB-aspectTerm\nwere\tO\nbacklit\tT-0\n.\tO\n\nAcer\tO\nwas\tO\nno\tO\nhelp\tO\nand\tO\nGarmin\tO\ncould\tO\nnot\tO\ndetermine\tT-0\nthe\tO\nproblem(after\tO\nspending\tO\nabout\tO\n2\tO\nhours\tO\nwith\tO\nme\tO\n)\tO\n,\tO\nso\tO\nI\tO\nreturned\tO\nit\tO\nand\tO\npurchased\tO\na\tO\nToshiba\tT-1\nR700\tT-1\nthat\tO\nseems\tO\neven\tO\nnicer\tO\nand\tO\nI\tO\nwas\tO\nable\tO\nto\tO\nload\tO\nall\tO\nof\tO\nmy\tO\nsoftware\tB-aspectTerm\nwith\tO\nno\tO\nproblem\tO\n.\tO\n\nI\tO\nwish\tO\nthe\tO\nvolume\tB-aspectTerm\ncould\tO\nbe\tO\nlouder\tT-1\nand\tO\nthe\tO\nmouse\tO\ndid\tO\nnt\tO\nbreak\tO\nafter\tO\nonly\tO\na\tO\nmonth\tT-0\n.\tO\n\nI\tO\nwish\tO\nthe\tO\nvolume\tT-1\ncould\tO\nbe\tO\nlouder\tO\nand\tO\nthe\tO\nmouse\tB-aspectTerm\ndid\tO\nnt\tO\nbreak\tT-0\nafter\tO\nonly\tO\na\tO\nmonth\tO\n.\tO\n\nI\tO\nplay\tO\na\tO\nlot\tO\nof\tO\ncasual\tO\ngames\tT-0\nonline\tO\n,\tO\nand\tO\nthe\tO\ntouchpad\tB-aspectTerm\nis\tO\nvery\tO\nresponsive\tT-1\n.\tO\n\nGranted\tT-0\n,\tO\nit\tO\n's\tO\nstill\tO\na\tO\nvery\tO\nnew\tO\nlaptop\tO\nbut\tO\nin\tO\ncomparison\tO\nto\tO\nmy\tO\nprevious\tO\nlaptops\tT-1\nand\tO\ndesktops\tO\n,\tO\nmy\tO\nMac\tO\nboots\tB-aspectTerm\nup\tI-aspectTerm\nnoticeably\tO\nquicker\tO\n.\tO\n\nIt\tO\ncaught\tO\na\tO\nvirus\tO\nthat\tO\ncompletely\tO\nwiped\tT-0\nout\tT-0\nmy\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nin\tO\na\tO\nmatter\tT-1\nof\tO\nhours\tO\n.\tO\n\nIt\tO\nis\tO\neverything\tO\nI\tO\n'd\tO\nhoped\tT-0\nit\tO\nwould\tO\nbe\tO\nfrom\tT-2\na\tO\nlook\tB-aspectTerm\nand\tI-aspectTerm\nfeel\tI-aspectTerm\nstandpoint\tI-aspectTerm\n,\tO\nbut\tO\nsomehow\tO\na\tO\nbit\tO\nmore\tO\nsturdy\tT-3\n.\tT-1\n\nthe\tO\nonly\tO\nfact\tO\ni\tO\ndo\tO\nnt\tO\nlike\tO\nabout\tO\napples\tO\nis\tT-1\nthey\tT-1\ngenerally\tT-1\nuse\tT-1\nsafari\tB-aspectTerm\nand\tO\ni\tO\ndo\tO\nnt\tO\nuse\tO\nsafari\tO\nbut\tO\nafter\tO\ni\tO\ninstall\tO\nMozzilla\tO\nfirfox\tO\ni\tO\nlove\tO\nevery\tO\nsingle\tO\nbit\tO\nabout\tO\nit\tO\n.\tT-0\n\nthe\tO\nonly\tO\nfact\tO\ni\tO\ndo\tO\nnt\tO\nlike\tT-0\nabout\tO\napples\tO\nis\tO\nthey\tO\ngenerally\tO\nuse\tO\nsafari\tT-1\nand\tO\ni\tO\ndo\tO\nnt\tO\nuse\tO\nsafari\tB-aspectTerm\nbut\tO\nafter\tO\ni\tO\ninstall\tT-2\nMozzilla\tO\nfirfox\tO\ni\tO\nlove\tO\nevery\tO\nsingle\tO\nbit\tO\nabout\tO\nit\tO\n.\tO\n\nthe\tO\nonly\tO\nfact\tO\ni\tO\ndo\tO\nnt\tO\nlike\tO\nabout\tO\napples\tO\nis\tO\nthey\tO\ngenerally\tO\nuse\tO\nsafari\tO\nand\tO\ni\tO\ndo\tO\nnt\tO\nuse\tO\nsafari\tO\nbut\tO\nafter\tO\ni\tO\ninstall\tT-1\nMozzilla\tB-aspectTerm\nfirfox\tI-aspectTerm\ni\tT-0\nlove\tT-0\nevery\tO\nsingle\tO\nbit\tO\nabout\tO\nit\tO\n.\tO\n\nThe\tO\nBluetooth\tB-aspectTerm\nwas\tO\nnot\tO\nthere\tO\nat\tO\nall\tO\n,\tO\nand\tO\nthe\tO\nfingerprint\tT-0\nreader\tT-0\ndriver\tT-1\nwould\tO\nbe\tO\nthere\tO\n,\tO\nbut\tO\nthe\tO\nsoftware\tT-2\nwould\tO\nhang\tO\nafter\tO\ninstallation\tT-3\nwas\tO\n1/2\tO\nway\tO\ndone\tO\n.\tO\n\nThe\tO\nBluetooth\tO\nwas\tO\nnot\tO\nthere\tO\nat\tO\nall\tO\n,\tO\nand\tO\nthe\tO\nfingerprint\tB-aspectTerm\nreader\tI-aspectTerm\ndriver\tI-aspectTerm\nwould\tO\nbe\tO\nthere\tO\n,\tO\nbut\tO\nthe\tO\nsoftware\tT-0\nwould\tO\nhang\tO\nafter\tO\ninstallation\tO\nwas\tO\n1/2\tO\nway\tO\ndone\tO\n.\tT-1\n\nThe\tO\nBluetooth\tT-1\nwas\tO\nnot\tO\nthere\tO\nat\tO\nall\tO\n,\tO\nand\tO\nthe\tO\nfingerprint\tT-2\nreader\tT-2\ndriver\tT-2\nwould\tO\nbe\tO\nthere\tO\n,\tO\nbut\tO\nthe\tO\nsoftware\tB-aspectTerm\nwould\tT-0\nhang\tT-0\nafter\tO\ninstallation\tO\nwas\tO\n1/2\tO\nway\tO\ndone\tO\n.\tO\n\nGreat\tO\nbattery\tT-1\n,\tO\nspeed\tB-aspectTerm\n,\tO\ndisplay\tT-0\n.\tT-0\n\nGreat\tO\nbattery\tT-0\n,\tO\nspeed\tT-1\n,\tO\ndisplay\tB-aspectTerm\n.\tO\n\nThe\tT-1\ndelivery\tB-aspectTerm\nwas\tT-2\nfast\tT-2\n,\tO\nand\tO\nI\tO\nwould\tO\nnot\tO\nhesitate\tO\nto\tO\npurchase\tO\nthis\tO\nlaptop\tO\nagain\tO\n.\tO\n\nI\tO\n've\tO\nbeen\tO\nimpressed\tO\nwith\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nand\tO\nthe\tO\nperformance\tT-0\nfor\tO\nsuch\tO\na\tO\nsmall\tO\namount\tO\nof\tO\nmemory\tT-1\n.\tO\n\nI\tO\n've\tO\nbeen\tO\nimpressed\tO\nwith\tO\nthe\tO\nbattery\tO\nlife\tO\nand\tO\nthe\tO\nperformance\tB-aspectTerm\nfor\tO\nsuch\tO\na\tO\nsmall\tO\namount\tO\nof\tO\nmemory\tT-0\n.\tO\n\nI\tO\n've\tO\nbeen\tO\nimpressed\tT-0\nwith\tO\nthe\tO\nbattery\tT-1\nlife\tO\nand\tO\nthe\tO\nperformance\tO\nfor\tO\nsuch\tO\na\tO\nsmall\tO\namount\tO\nof\tO\nmemory\tB-aspectTerm\n.\tO\n\nIt\tT-1\n's\tT-1\napplications\tB-aspectTerm\nare\tO\nterrific\tO\n,\tO\nincluding\tO\nthe\tO\nreplacements\tT-0\nfor\tO\nMicrosoft\tO\noffice\tO\n.\tO\n\nIt\tO\n's\tO\napplications\tT-0\nare\tO\nterrific\tO\n,\tO\nincluding\tO\nthe\tO\nreplacements\tT-1\nfor\tO\nMicrosoft\tB-aspectTerm\noffice\tI-aspectTerm\n.\tO\n\nthey\tO\nimproved\tO\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tB-aspectTerm\n,\tO\nappearance\tT-0\n,\tO\ncooling\tT-1\nsystem\tT-1\n,\tO\ngraphics\tT-2\ncard\tT-2\n,\tO\netc\tO\n.\tO\n\nthey\tO\nimproved\tT-0\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tO\n,\tO\nappearance\tB-aspectTerm\n,\tO\ncooling\tO\nsystem\tO\n,\tO\ngraphics\tO\ncard\tO\n,\tO\netc\tO\n.\tO\n\nthey\tO\nimproved\tT-1\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tT-0\n,\tO\nappearance\tO\n,\tO\ncooling\tB-aspectTerm\nsystem\tI-aspectTerm\n,\tO\ngraphics\tO\ncard\tO\n,\tO\netc\tO\n.\tO\n\nthey\tO\nimproved\tT-4\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tT-0\n,\tO\nappearance\tT-1\n,\tO\ncooling\tT-2\nsystem\tT-2\n,\tO\ngraphics\tB-aspectTerm\ncard\tI-aspectTerm\n,\tO\netc\tO\n.\tT-3\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nwebcam\tI-aspectTerm\nand\tO\nbuilt\tT-2\n-\tT-2\nin\tT-2\nmic\tT-2\nwere\tO\nshorting\tT-0\nout\tT-0\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tT-1\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tO\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tO\nand\tO\nmic\tO\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tO\n-\tO\nin\tO\nwebcam\tO\nand\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nmic\tI-aspectTerm\nwere\tO\nshorting\tT-0\nout\tO\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tO\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tO\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tO\nand\tO\nmic\tO\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tO\n-\tO\nin\tO\nwebcam\tO\nand\tO\nbuilt\tO\n-\tO\nin\tO\nmic\tO\nwere\tO\nshorting\tT-0\nout\tO\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tO\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tT-1\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tB-aspectTerm\nand\tO\nmic\tO\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tO\n-\tO\nin\tO\nwebcam\tT-0\nand\tO\nbuilt\tO\n-\tO\nin\tO\nmic\tO\nwere\tO\nshorting\tO\nout\tO\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tO\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tO\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tO\nand\tO\nmic\tB-aspectTerm\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nMy\tO\ndad\tO\nhas\tO\none\tO\nof\tO\nthe\tO\nvery\tO\nfirst\tO\nToshibas\tO\never\tO\nmade\tO\n,\tO\nyes\tO\nits\tO\nabit\tO\nslow\tO\nnow\tO\nbut\tO\nstill\tT-0\nworks\tT-1\nwell\tO\nand\tO\ni\tO\nhooked\tO\nto\tO\nmy\tO\nethernet\tB-aspectTerm\n!\tO\n\nMostly\tO\nI\tO\nlove\tT-0\nthe\tO\ndrag\tB-aspectTerm\nand\tI-aspectTerm\ndrop\tI-aspectTerm\nfeature\tI-aspectTerm\n.\tT-1\n\noh\tO\nyeah\tO\n,\tO\nand\tO\nif\tO\nthe\tO\nfancy\tO\nwebcam\tB-aspectTerm\nbreaks\tO\nguess\tO\nwho\tO\nyou\tO\nhave\tO\nto\tO\nsend\tO\nit\tO\nto\tO\nto\tO\nget\tO\nit\tO\nfixed\tT-0\n?\tT-1\n\nI\tO\nordered\tO\nthrough\tO\nMacMall\tT-0\n,\tO\nwhich\tO\nsaved\tO\nme\tO\nthe\tO\nsales\tB-aspectTerm\ntax\tI-aspectTerm\nI\tO\nwould\tO\nhave\tO\nincurred\tO\nbuying\tO\nlocally\tO\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tO\nsoftware\tB-aspectTerm\npackages\tI-aspectTerm\nthat\tO\ncame\tO\nfor\tO\nfree\tO\nincluding\tO\niWork\tT-0\n,\tO\nGarageBand\tT-1\n,\tO\nand\tO\niMovie\tT-2\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tO\nsoftware\tT-2\npackages\tO\nthat\tO\ncame\tO\nfor\tO\nfree\tO\nincluding\tO\niWork\tB-aspectTerm\n,\tO\nGarageBand\tT-0\n,\tO\nand\tO\niMovie\tT-1\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tT-0\nsoftware\tT-3\npackages\tT-3\nthat\tO\ncame\tO\nfor\tO\nfree\tT-1\nincluding\tT-2\niWork\tO\n,\tO\nGarageBand\tB-aspectTerm\n,\tO\nand\tO\niMovie\tO\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tO\nsoftware\tT-0\npackages\tO\nthat\tO\ncame\tO\nfor\tO\nfree\tO\nincluding\tO\niWork\tT-1\n,\tO\nGarageBand\tO\n,\tO\nand\tO\niMovie\tB-aspectTerm\n.\tO\n\nThe\tT-0\nscreen\tB-aspectTerm\nis\tO\nvery\tO\nlarge\tO\nand\tO\ncrystal\tO\nclear\tO\nwith\tO\namazing\tO\ncolors\tT-1\nand\tO\nresolution\tO\n.\tO\n\nThe\tO\nscreen\tT-1\nis\tO\nvery\tO\nlarge\tO\nand\tO\ncrystal\tO\nclear\tO\nwith\tO\namazing\tT-0\ncolors\tT-0\nand\tO\nresolution\tB-aspectTerm\n.\tO\n\nAfter\tO\na\tO\nlittle\tO\nmore\tT-2\nthan\tO\na\tO\nyear\tO\nof\tO\nowning\tO\nmy\tO\nMacBook\tT-0\nPro\tT-0\n,\tO\nthe\tO\nmonitor\tB-aspectTerm\nhas\tO\ncompletely\tO\ndied\tT-1\n.\tO\n\nThe\tO\nbrand\tO\nof\tO\niTunes\tB-aspectTerm\nhas\tO\njust\tO\nbecome\tO\ningrained\tO\nin\tO\nour\tO\nlexicon\tT-0\nnow\tO\n,\tO\nbut\tO\nkeep\tO\nin\tO\nmind\tO\nthat\tO\nApple\tO\nstarted\tO\nit\tO\nall\tO\n.\tO\n\nSize\tB-aspectTerm\n:\tO\nI\tO\nknow\tT-0\n13\tO\nis\tO\nsmall\tO\n(\tO\nespecially\tO\nfor\tO\na\tO\ndesktop\tT-1\nreplacement\tO\n)\tO\nbut\tO\nwith\tO\nan\tO\nexternal\tO\nmonitor\tT-2\n,\tO\nwho\tO\ncares\tO\n.\tO\n\nSize\tO\n:\tO\nI\tO\nknow\tO\n13\tT-0\nis\tO\nsmall\tO\n(\tO\nespecially\tO\nfor\tO\na\tO\ndesktop\tT-1\nreplacement\tO\n)\tO\nbut\tO\nwith\tO\nan\tO\nexternal\tB-aspectTerm\nmonitor\tI-aspectTerm\n,\tO\nwho\tO\ncares\tO\n.\tO\n\nAdditional\tO\ncaveat\tO\n:\tO\nthe\tO\nbase\tB-aspectTerm\ninstallation\tI-aspectTerm\ncomes\tT-0\nwith\tO\nsome\tO\nToshiba\tT-2\n-\tT-2\nspecific\tT-2\nsoftware\tT-2\nthat\tO\nmay\tO\nor\tO\nmay\tO\nnot\tO\nbe\tO\nto\tO\na\tO\nuser\tT-1\n's\tT-1\nliking\tT-1\n.\tO\n\nAdditional\tO\ncaveat\tO\n:\tO\nthe\tO\nbase\tO\ninstallation\tO\ncomes\tO\nwith\tO\nsome\tO\nToshiba\tO\n-\tO\nspecific\tO\nsoftware\tB-aspectTerm\nthat\tT-0\nmay\tO\nor\tO\nmay\tO\nnot\tO\nbe\tO\nto\tO\na\tO\nuser\tO\n's\tO\nliking\tO\n.\tO\n\nÂ\tO\nTaking\tO\nit\tO\nback\tO\nto\tO\nBest\tO\nBuy\tO\nI\tO\nfound\tO\nthat\tO\na\tO\ntiny\tO\nplastic\tO\npiece\tO\ninside\tO\nhad\tO\nbroken\tO\n(\tO\nmanuf\tB-aspectTerm\nissue\tO\n)\tO\n.\tT-0\n\nThe\tT-0\ndisplay\tB-aspectTerm\nis\tO\nincredibly\tO\nbright\tT-1\n,\tO\nmuch\tO\nbrighter\tO\nthan\tO\nmy\tO\nPowerBook\tO\nand\tO\nvery\tO\ncrisp\tO\n.\tO\n\nThe\tO\nAMD\tB-aspectTerm\nTurin\tI-aspectTerm\nprocessor\tI-aspectTerm\nseems\tO\nto\tO\nalways\tO\nperform\tT-0\nso\tO\nmuch\tT-1\nbetter\tO\nthan\tO\nIntel\tO\n.\tO\n\nThe\tO\nAMD\tT-1\nTurin\tT-1\nprocessor\tT-1\nseems\tO\nto\tO\nalways\tO\nperform\tO\nso\tO\nmuch\tT-2\nbetter\tT-2\nthan\tO\nIntel\tB-aspectTerm\n.\tO\n\nÂ\tO\nAfter\tT-1\nthat\tO\nthe\tO\nsaid\tO\nit\tO\nwas\tO\nunder\tO\nwarranty\tB-aspectTerm\n.\tT-2\n\nThe\tO\nstart\tB-aspectTerm\nmenu\tI-aspectTerm\nis\tO\nnot\tO\nthe\tO\neasiest\tO\nthing\tT-0\nto\tT-0\nnavigate\tT-1\ndue\tO\nto\tO\nthe\tO\nstacking\tO\n.\tO\n\nThe\tO\nstart\tO\nmenu\tO\nis\tO\nnot\tO\nthe\tO\neasiest\tT-0\nthing\tO\nto\tO\nnavigate\tB-aspectTerm\ndue\tO\nto\tO\nthe\tO\nstacking\tO\n.\tO\n\nThe\tO\nservice\tB-aspectTerm\ntech\tI-aspectTerm\nsaid\tO\nhe\tO\nhad\tO\ntried\tO\nto\tO\nduplicate\tT-0\nthe\tO\ndamage\tO\nand\tO\nwas\tO\nn't\tO\nable\tO\nto\tO\nrecreate\tO\nit\tO\ntherefore\tO\nit\tO\nhad\tO\nto\tO\nbe\tO\ntheir\tO\ndefect\tO\n.\tO\n\nThe\tT-1\ntech\tB-aspectTerm\nstore\tI-aspectTerm\nI\tT-2\npurchased\tT-2\nthis\tT-2\nfrom\tT-2\nsent\tO\nit\tO\nback,,,,,eventually\tO\nI\tO\ngot\tO\na\tO\nnew\tT-0\nor\tT-0\nrepaired\tT-0\nmachine\tT-0\napproximately\tO\n3\tO\nweeks\tO\nlater\tO\n.\tO\n\nReally\tO\nlike\tO\nthe\tO\ntextured\tT-1\nsurface\tB-aspectTerm\nwhich\tO\nshows\tT-0\nno\tO\nfingerprints\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nbright\tO\nand\tO\nthe\tO\nkeyboard\tT-1\nis\tO\nnice\tT-0\n;\tO\n\nThe\tO\nscreen\tT-2\nis\tO\nbright\tT-1\nand\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\nnice\tT-0\n;\tO\n\nBut\tO\nthe\tO\nmachine\tT-1\nis\tO\nawesome\tT-0\nand\tO\niLife\tB-aspectTerm\nis\tO\ngreat\tO\nand\tO\nI\tO\nlove\tO\nSnow\tO\nLeopard\tO\nX.\tO\n\nBut\tO\nthe\tO\nmachine\tT-1\nis\tO\nawesome\tO\nand\tO\niLife\tO\nis\tO\ngreat\tT-0\nand\tO\nI\tO\nlove\tO\nSnow\tB-aspectTerm\nLeopard\tI-aspectTerm\nX.\tI-aspectTerm\n\nHigh\tT-1\nprice\tB-aspectTerm\ntag\tI-aspectTerm\n,\tO\nhowever\tT-0\n.\tO\n\nI\tT-1\nthought\tT-1\nlearning\tT-1\nthe\tT-1\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nwould\tT-0\nbe\tO\nhard\tO\n,\tO\nbut\tO\nit\tO\nis\tO\neasily\tO\npicked\tO\nup\tO\nif\tO\nyou\tO\nare\tO\nfamiliar\tO\nwith\tO\na\tO\nPC\tT-2\n.\tO\n\nI\tO\nhad\tO\nstatic\tO\nin\tO\nthe\tO\noutput\tT-1\n,\tO\nand\tO\nI\tO\nhad\tO\nto\tO\nreduce\tO\nthe\tO\nsound\tB-aspectTerm\noutput\tI-aspectTerm\nquality\tI-aspectTerm\nto\tO\n\"\tO\nFM\tT-0\n\"\tO\nas\tO\nopposed\tT-2\nto\tT-2\nthe\tT-2\ndefault\tT-2\n\"\tO\nCD\tO\n.\tO\n\nI\tO\ncustom\tO\nordered\tO\nthe\tO\nmachine\tO\nfrom\tO\nHP\tO\nand\tO\ncould\tO\nNOT\tO\nunderstand\tT-0\nthe\tO\ntechie\tB-aspectTerm\ndue\tO\nto\tO\nhis\tO\naccent\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tT-0\nto\tO\nuse\tB-aspectTerm\nand\tO\nlightweight\tT-1\n.\tO\n\nI\tT-1\nwent\tT-1\nto\tT-1\nToshiba\tB-aspectTerm\nonline\tI-aspectTerm\nhelp\tI-aspectTerm\nand\tO\nfound\tO\nsome\tO\nsuggestions\tO\nto\tO\nfix\tT-0\nit\tT-0\n.\tO\n\nThey\tT-0\nalso\tT-0\nhave\tT-0\na\tT-0\nlonger\tT-0\nservice\tB-aspectTerm\nlife\tI-aspectTerm\nthan\tO\nother\tO\ncomputers\tT-1\n(\tO\nI\tO\nhave\tO\nseveral\tO\nfriends\tO\nwho\tO\nstill\tO\nuse\tO\nthe\tO\nolder\tO\nApple\tO\nPowerBooks\tO\n)\tO\n.\tO\n\nIf\tO\nyou\tO\ncheck\tO\nyou\tO\nwill\tO\nfind\tO\nthe\tO\nsame\tO\nnotebook\tT-1\nwith\tO\nthe\tO\nabove\tO\nmissing\tT-0\nports\tB-aspectTerm\nand\tO\na\tT-2\ndual\tT-2\ncore\tT-2\nAMD\tT-2\nor\tO\nIntel\tT-3\nprocessor\tT-3\n.\tO\n\nIf\tO\nyou\tO\ncheck\tO\nyou\tO\nwill\tO\nfind\tO\nthe\tO\nsame\tT-0\nnotebook\tT-1\nwith\tO\nthe\tO\nabove\tO\nmissing\tO\nports\tO\nand\tO\na\tO\ndual\tO\ncore\tT-2\nAMD\tO\nor\tO\nIntel\tO\nprocessor\tB-aspectTerm\n.\tO\n\nThis\tO\nlaptop\tT-1\nis\tO\na\tO\ngreat\tT-0\nprice\tB-aspectTerm\nand\tO\nhas\tO\na\tO\nsleek\tT-2\nlook\tO\n.\tO\n\nThis\tO\nlaptop\tO\nis\tO\na\tO\ngreat\tO\nprice\tO\nand\tO\nhas\tO\na\tO\nsleek\tT-0\nlook\tB-aspectTerm\n.\tO\n\nI\tO\nespecially\tO\nlike\tO\nthe\tO\nkeyboard\tB-aspectTerm\nwhich\tO\nhas\tO\nchiclet\tO\ntype\tO\nkeys\tT-0\n.\tO\n\nI\tO\nespecially\tO\nlike\tO\nthe\tO\nkeyboard\tT-0\nwhich\tO\nhas\tO\nchiclet\tT-1\ntype\tT-1\nkeys\tB-aspectTerm\n.\tO\n\nSmall\tT-0\nscreen\tB-aspectTerm\nsomewhat\tT-1\nlimiting\tT-1\nbut\tO\ngreat\tT-2\nfor\tO\ntravel\tT-3\n.\tT-3\n\nRuns\tO\nHot\tO\nO\tO\nI\tO\nthought\tO\nwe\tO\nwere\tO\npaying\tT-0\nfor\tT-0\nquality\tB-aspectTerm\nin\tO\nour\tO\ndecision\tO\nto\tO\nbuy\tO\nan\tO\nApple\tO\nproduct\tO\n.\tO\n\nFor\tO\nthe\tO\nnot\tO\nso\tO\ngood\tO\n,\tO\nI\tO\ngot\tO\nthe\tO\nstock\tB-aspectTerm\nscreen\tI-aspectTerm\n-\tO\nwhich\tO\nis\tO\nVERY\tO\nglossy\tT-0\n.\tO\n\nThe\tT-0\ngray\tB-aspectTerm\ncolor\tI-aspectTerm\nwas\tT-1\na\tT-1\ngood\tT-1\nchoice\tT-1\n.\tT-2\n\nI\tO\nwould\tO\nlike\tT-0\nto\tO\nhave\tO\nvolume\tB-aspectTerm\nbuttons\tI-aspectTerm\nrather\tO\nthan\tO\nthe\tO\nadjustment\tT-1\nthat\tO\nis\tO\non\tO\nthe\tO\nfront\tO\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\na\tO\nAMD\tO\nSemprom\tO\nat\tO\n2.1\tO\nghz\tO\nis\tO\na\tO\nbummer\tO\nit\tO\ndoes\tO\nnot\tO\nhave\tO\nthe\tO\npower\tT-0\nfor\tO\nHD\tT-1\nor\tO\nheavy\tO\ncomputing\tO\n.\tO\n\nThe\tO\nprocessor\tO\na\tO\nAMD\tO\nSemprom\tT-0\nat\tO\n2.1\tO\nghz\tO\nis\tO\na\tO\nbummer\tO\nit\tO\ndoes\tO\nnot\tO\nhave\tO\nthe\tO\npower\tO\nfor\tO\nHD\tO\nor\tO\nheavy\tO\ncomputing\tB-aspectTerm\n.\tO\n\nI\tO\nbought\tT-0\na\tO\nprotector\tB-aspectTerm\nfor\tO\nmy\tO\nkey\tT-1\npad\tT-1\nand\tO\nit\tO\nworks\tO\ngreat\tO\n:)\tO\n\nI\tO\nbought\tO\na\tO\nprotector\tO\nfor\tO\nmy\tO\nkey\tB-aspectTerm\npad\tI-aspectTerm\nand\tT-1\nit\tO\nworks\tO\ngreat\tT-0\n:)\tT-0\n\nIt\tO\nseems\tO\nthey\tO\ncould\tO\nhave\tO\nupdated\tT-1\nXP\tB-aspectTerm\nand\tO\ndone\tO\nwithout\tO\ncreating\tO\nVista\tO\n.\tT-0\n\nIt\tO\nseems\tO\nthey\tO\ncould\tO\nhave\tO\nupdated\tT-1\nXP\tO\nand\tO\ndone\tT-0\nwithout\tO\ncreating\tO\nVista\tB-aspectTerm\n.\tO\n\nÂ\tO\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tT-1\nfast\tO\nand\tO\nhas\tO\ngreat\tO\ngraphics\tO\nfor\tO\nthe\tO\nmoney\tO\n.\tT-1\n\nÂ\tO\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nfast\tT-1\nand\tT-1\nhas\tO\ngreat\tO\ngraphics\tB-aspectTerm\nfor\tO\nthe\tO\nmoney\tO\n.\tT-0\n\nI\tO\nlike\tO\nhow\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nis\tO\nso\tO\nsimple\tT-0\nand\tO\neasy\tT-1\nto\tO\nuse\tO\n.\tO\n\nI\tO\nlike\tO\nhow\tO\nthe\tO\nMac\tO\nOS\tO\nis\tO\nso\tO\nsimple\tO\nand\tO\neasy\tT-0\nto\tT-0\nuse\tB-aspectTerm\n.\tO\n\nWhile\tO\nApple\tO\n's\tO\nsaving\tO\ngrace\tO\nis\tO\nthe\tO\nfact\tO\nthat\tO\nthey\tO\nat\tO\nleast\tO\nstand\tT-2\nbehind\tO\ntheir\tO\nproducts\tO\n,\tO\nand\tO\ntheir\tO\nsupport\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nit\tO\nwould\tO\nbe\tO\nnice\tO\nif\tO\ntheir\tO\nproducts\tO\nwere\tO\nmore\tO\nreliable\tO\nto\tO\njustify\tT-0\nthe\tO\npremium\tT-1\n.\tO\n\nI\tO\nwas\tO\nready\tO\nto\tO\ntake\tO\nit\tO\nback\tO\nfor\tO\na\tO\nrefund\tT-1\n,\tO\nbut\tO\nthe\tO\nGeek\tB-aspectTerm\nSquad\tI-aspectTerm\ncamed\tT-2\nthrough\tO\nand\tO\npointed\tT-3\nme\tO\nin\tO\nthe\tO\nright\tO\ndirection\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\n.\tT-0\n\nonly\tO\ngood\tT-0\nthing\tO\nis\tO\nthe\tO\ngraphics\tB-aspectTerm\nquality\tI-aspectTerm\n.\tO\n\nThe\tO\nother\tO\nlock\tT-0\n-\tT-0\nup\tT-0\nproblems\tT-0\nare\tO\nfrom\tO\na\tO\nmyriad\tO\nof\tO\ncauses\tO\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nbeing\tO\na\tO\ncorrupted\tO\nversion\tO\nof\tO\nAppleworks\tB-aspectTerm\nwhich\tO\ncan\tO\nrender\tT-1\nthe\tT-1\nbrowser\tT-1\nuseless\tT-1\n.\tO\n\nThe\tO\nother\tO\nlock\tT-0\n-\tT-0\nup\tT-0\nproblems\tO\nare\tO\nfrom\tO\na\tO\nmyriad\tO\nof\tO\ncauses\tO\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nbeing\tO\na\tO\ncorrupted\tT-1\nversion\tO\nof\tO\nAppleworks\tO\nwhich\tO\ncan\tO\nrender\tO\nthe\tO\nbrowser\tB-aspectTerm\nuseless\tO\n.\tO\n\nThe\tO\npaint\tB-aspectTerm\nwears\tO\noff\tO\neasily\tT-0\ndue\tO\nto\tO\nthe\tO\nkeyboard\tT-1\nbeing\tO\nfarther\tO\nback\tO\nthan\tO\nusual\tO\n.\tO\n\nThe\tO\npaint\tT-1\nwears\tT-1\noff\tT-1\neasily\tO\ndue\tO\nto\tO\nthe\tO\nkeyboard\tB-aspectTerm\nbeing\tO\nfarther\tT-0\nback\tT-0\nthan\tO\nusual\tO\n.\tO\n\nI\tO\nhad\tO\npurchased\tO\nit\tO\nfrom\tO\na\tO\nmajor\tO\nelectronics\tT-0\nstore\tO\nand\tO\ntook\tO\nit\tO\nto\tO\ntheir\tO\nservice\tB-aspectTerm\ndepartment\tI-aspectTerm\nto\tO\nfind\tO\nout\tO\nwhat\tO\nthe\tO\nproblem\tT-1\nwas\tO\n.\tO\n\nThe\tO\nstore\tO\nhonored\tT-0\ntheir\tO\nwarrenty\tB-aspectTerm\nand\tO\nmade\tO\nthe\tO\ncomment\tO\nthat\tO\nthey\tO\ndo\tO\nn't\tO\neven\tO\nrecommend\tO\nthe\tO\nHP\tO\nbrand\tO\nbecause\tO\nof\tO\nthe\tO\nproblems\tT-1\nwith\tO\ntheir\tO\nwarrentys\tO\n.\tO\n\nThe\tO\nstore\tO\nhonored\tO\ntheir\tO\nwarrenty\tT-0\nand\tO\nmade\tO\nthe\tO\ncomment\tO\nthat\tO\nthey\tO\ndo\tO\nn't\tO\neven\tO\nrecommend\tT-3\nthe\tO\nHP\tT-1\nbrand\tO\nbecause\tO\nof\tO\nthe\tO\nproblems\tT-2\nwith\tO\ntheir\tO\nwarrentys\tB-aspectTerm\n.\tO\n\nI\tO\nalways\tO\nuse\tO\na\tO\nbackup\tT-0\nhard\tB-aspectTerm\ndisk\tI-aspectTerm\nto\tO\nstore\tO\nimportant\tO\nfiles\tO\nat\tO\nall\tO\ntimes\tO\n.\tO\n\nThey\tO\nsent\tO\nout\tO\nthe\tO\nbox\tO\nright\tO\naway\tO\nfor\tO\nme\tO\nto\tO\nsend\tO\nin\tO\nmy\tO\ncomputer\tO\n,\tO\nthey\tO\npaid\tT-1\npostage\tO\nand\tO\nwhatnot\tO\n,\tO\nbut\tO\nwhen\tO\nI\tO\ngot\tO\nmy\tO\ncomputer\tO\nback\tO\nit\tO\nstill\tO\nwas\tO\nn't\tO\nrunning\tB-aspectTerm\nright\tO\n,\tO\nand\tO\nnow\tO\nmy\tO\nCD\tO\ndrive\tO\nwas\tO\nn't\tO\nreading\tT-0\nanything\tO\n!\tO\n\nThey\tO\nsent\tO\nout\tO\nthe\tO\nbox\tO\nright\tO\naway\tO\nfor\tO\nme\tO\nto\tO\nsend\tO\nin\tO\nmy\tO\ncomputer\tT-0\n,\tO\nthey\tO\npaid\tO\npostage\tO\nand\tO\nwhatnot\tO\n,\tO\nbut\tO\nwhen\tO\nI\tO\ngot\tO\nmy\tO\ncomputer\tT-1\nback\tO\nit\tO\nstill\tO\nwas\tO\nn't\tO\nrunning\tO\nright\tO\n,\tO\nand\tO\nnow\tO\nmy\tO\nCD\tB-aspectTerm\ndrive\tI-aspectTerm\nwas\tO\nn't\tO\nreading\tT-2\nanything\tO\n!\tO\n\nBut\tT-0\nthe\tT-0\nscreen\tB-aspectTerm\nsize\tI-aspectTerm\nis\tO\nnot\tO\nthat\tO\nbad\tO\nfor\tO\nemail\tO\nand\tO\nweb\tO\nbrowsing\tT-1\n.\tO\n\nBut\tO\nthe\tO\nscreen\tT-0\nsize\tT-1\nis\tO\nnot\tO\nthat\tO\nbad\tO\nfor\tO\nemail\tT-2\nand\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\n.\tO\n\nOnce\tO\nI\tO\nremoved\tO\nall\tO\nthe\tO\nsoftware\tB-aspectTerm\nthe\tO\nlaptop\tO\nloads\tT-1\nin\tO\n15\tO\n-\tO\n20\tO\nseconds\tT-0\n.\tO\n\nOnce\tO\nI\tO\nremoved\tT-0\nall\tO\nthe\tO\nsoftware\tO\nthe\tO\nlaptop\tO\nloads\tB-aspectTerm\nin\tO\n15\tO\n-\tO\n20\tO\nseconds\tO\n.\tO\n\nOn\tO\nmy\tO\nPowerBook\tO\nG4\tO\nI\tO\nwould\tO\nnever\tT-0\nuse\tT-0\nthe\tO\ntrackpad\tB-aspectTerm\nI\tO\nwould\tO\nuse\tO\nan\tO\nexternal\tO\nmouse\tT-1\nbecause\tO\nI\tO\ndid\tO\nn't\tO\nlike\tO\nthe\tO\ntrackpad\tT-2\n.\tO\n\nOn\tO\nmy\tO\nPowerBook\tO\nG4\tO\nI\tO\nwould\tO\nnever\tO\nuse\tO\nthe\tO\ntrackpad\tT-1\nI\tO\nwould\tT-0\nuse\tO\nan\tO\nexternal\tB-aspectTerm\nmouse\tI-aspectTerm\nbecause\tO\nI\tO\ndid\tO\nn't\tO\nlike\tO\nthe\tO\ntrackpad\tT-2\n.\tO\n\nOn\tO\nmy\tO\nPowerBook\tO\nG4\tO\nI\tO\nwould\tO\nnever\tO\nuse\tO\nthe\tO\ntrackpad\tT-1\nI\tO\nwould\tT-0\nuse\tO\nan\tO\nexternal\tO\nmouse\tT-2\nbecause\tO\nI\tO\ndid\tO\nn't\tO\nlike\tO\nthe\tO\ntrackpad\tB-aspectTerm\n.\tO\n\nThis\tO\ncomputer\tO\ndoes\tO\nn't\tO\ndo\tO\nthat\tO\nwell\tO\nwith\tO\ncertain\tO\ngames\tB-aspectTerm\nit\tO\nca\tO\nn't\tO\nplay\tT-1\nsome\tO\nand\tO\nit\tO\nbecomes\tO\ntoo\tO\nhot\tO\nwhile\tO\nplaying\tT-0\ngames\tO\n.\tO\n\nObviously\tO\none\tO\nof\tO\nthe\tO\nmost\tO\nimportant\tT-0\nfeatures\tB-aspectTerm\nof\tO\nany\tO\ncomputer\tO\nis\tO\nthe\tO\n\"\tO\nhuman\tT-1\ninterface\tT-1\n.\tO\n\nYeah\tO\n,\tO\nof\tO\ncourse\tO\nsmarty\tO\npants\tO\n\"\tO\nfix\tO\nit\tO\nnow\")Software\tT-1\n-\tO\nCompared\tO\nto\tO\nthe\tO\nearly\tO\n2011\tO\nedition\tO\nI\tO\ndid\tO\nsee\tO\ninbuilt\tB-aspectTerm\napplications\tI-aspectTerm\ncrashing\tT-0\nand\tO\nit\tO\nprompted\tO\nme\tO\nto\tO\nsend\tO\nthe\tO\nreport\tO\nto\tO\nApple\tO\n(\tO\nwhich\tO\nI\tO\npromptly\tO\ndid\tO\n)\tO\n.\tT-1\n\nThe\tO\nbody\tB-aspectTerm\nis\tO\na\tO\nbit\tO\ncheaply\tT-0\nmade\tT-0\nso\tO\nit\tO\nwill\tO\nbe\tO\ninteresting\tO\nto\tO\nsee\tO\nhow\tO\nlong\tO\nit\tO\nholds\tO\nup\tO\n.\tO\n\nThe\tO\ni5\tB-aspectTerm\nblows\tO\nmy\tO\ndesktop\tT-0\nout\tO\nof\tO\nthe\tO\nwater\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\nrendering\tT-1\nvideos\tT-1\n.\tO\n\nWith\tO\na\tO\nmac\tO\nyou\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tT-1\nabout\tO\nantivirus\tB-aspectTerm\nsoftware\tI-aspectTerm\nor\tO\nfirewall\tT-0\n,\tO\nit\tO\n's\tO\nso\tO\nwonderful\tO\n.\tO\n\nWith\tO\na\tO\nmac\tO\nyou\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tT-1\nabout\tO\nantivirus\tT-0\nsoftware\tO\nor\tO\nfirewall\tB-aspectTerm\n,\tO\nit\tO\n's\tO\nso\tO\nwonderful\tO\n.\tO\n\nAm\tO\nvery\tO\nglad\tO\nI\tO\nbought\tT-1\nit\tO\n,\tO\ngreat\tO\nnetbook\tT-2\n,\tO\nlow\tT-0\nprice\tB-aspectTerm\n.\tO\n\nThe\tO\nApple\tB-aspectTerm\nteam\tI-aspectTerm\nalso\tO\nassists\tO\nyou\tO\nvery\tO\nnicely\tO\nwhen\tO\nchoosing\tO\nwhich\tO\ncomputer\tT-0\nis\tO\nright\tO\nfor\tO\nyou\tO\n:)\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tT-1\nis\tO\nVista\tB-aspectTerm\n,\tO\nyet\tO\nI\tO\nknow\tO\nVista\tT-0\nis\tO\nn't\tO\nthe\tO\nentire\tO\nissue\tO\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tO\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tO\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tO\nsystem\tO\n)\tO\n.\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tT-2\nis\tO\nVista\tT-3\n,\tO\nyet\tT-0\nI\tT-0\nknow\tT-0\nVista\tB-aspectTerm\nis\tT-1\nn't\tT-1\nthe\tT-1\nentire\tT-1\nissue\tT-1\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tT-4\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tO\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tO\nsystem\tO\n)\tO\n.\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tT-2\nis\tO\nVista\tO\n,\tO\nyet\tO\nI\tO\nknow\tO\nVista\tO\nis\tO\nn't\tO\nthe\tO\nentire\tO\nissue\tO\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tT-0\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tB-aspectTerm\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tT-1\nsystem\tT-1\n)\tO\n.\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tT-0\nis\tO\nVista\tT-1\n,\tO\nyet\tO\nI\tO\nknow\tO\nVista\tT-2\nis\tO\nn't\tO\nthe\tO\nentire\tT-4\nissue\tT-4\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tO\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tT-3\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n)\tO\n.\tO\n\nThe\tO\nvideo\tB-aspectTerm\nchat\tI-aspectTerm\nis\tO\nthe\tO\nonly\tO\nthing\tO\nthat\tO\nis\tO\niffy\tO\nabout\tO\nit\tO\nbut\tO\ni\tO\nm\tO\nsure\tO\nonce\tO\nthey\tO\nunpdate\tO\nthe\tO\nnext\tO\nversion\tT-0\non\tO\nthe\tO\nmacbook\tO\nbook\tO\nthe\tO\nquality\tO\nof\tO\nit\tO\nwill\tO\nbe\tO\nbetter\tO\n.\tO\n\nThe\tO\nvideo\tT-0\nchat\tT-0\nis\tO\nthe\tO\nonly\tO\nthing\tO\nthat\tO\nis\tO\niffy\tT-2\nabout\tO\nit\tO\nbut\tO\ni\tO\nm\tO\nsure\tO\nonce\tO\nthey\tO\nunpdate\tO\nthe\tO\nnext\tO\nversion\tT-1\non\tO\nthe\tO\nmacbook\tO\nbook\tO\nthe\tO\nquality\tB-aspectTerm\nof\tO\nit\tO\nwill\tO\nbe\tO\nbetter\tO\n.\tO\n\nThat\tO\nwhole\tO\nexperience\tO\nwas\tO\njust\tO\nridiculous\tO\nwe\tO\nsent\tO\nit\tO\nin\tO\nand\tO\nafter\tO\nthey\tO\ntold\tO\nus\tO\nthat\tO\nwe\tO\nhad\tO\nto\tO\npay\tO\n$\tO\n175\tO\nto\tO\nfix\tO\nit\tO\nwe\tO\nwere\tO\nlike\tO\nwe\tO\nwill\tO\njust\tO\nby\tO\na\tO\nportable\tT-0\nmouse\tB-aspectTerm\nwhich\tO\nwould\tO\nbe\tO\nway\tO\ncheaper\tO\nbut\tO\nthey\tO\nrefused\tT-1\nto\tO\nsend\tO\nthe\tO\nlaptop\tO\nback\tO\nuntil\tO\nwe\tO\npaid\tO\nthe\tO\n$\tO\n175\tO\nand\tO\nit\tO\nwas\tO\nfixed\tO\n.\tO\n\nFan\tB-aspectTerm\nvents\tT-1\nto\tO\nthe\tO\nside\tO\n,\tO\nso\tO\nno\tT-2\ncooling\tT-2\npad\tT-2\nneeded\tT-2\n,\tO\ngreat\tT-3\nfeature\tT-3\n!\tO\n\ni\tO\nuse\tO\nmy\tO\nmac\tO\nall\tO\nthe\tO\ntime\tO\n,\tO\ni\tT-0\nlove\tT-0\nthe\tT-0\nsoftware\tB-aspectTerm\n,\tO\nthe\tO\nway\tO\nit\tO\ntakes\tO\na\tO\nshort\tO\ntime\tO\nto\tT-1\nload\tT-1\nthings\tT-1\n,\tO\nhow\tO\neasy\tO\nit\tO\nis\tO\nto\tO\nuse\tO\nand\tO\nmost\tO\nof\tO\nall\tO\nhow\tO\nyou\tO\ndo\tT-2\nn't\tT-2\nhave\tT-2\nto\tT-2\nworry\tT-2\nabout\tT-2\nviruses\tT-2\n.\tO\n\nWasted\tO\nme\tO\nat\tO\nleast\tO\n8\tO\nhours\tT-0\nof\tO\ninstallation\tB-aspectTerm\ntime\tI-aspectTerm\n.\tO\n\nIt\tO\nhas\tO\nfar\tO\nexceeded\tO\nmy\tO\nexpectations\tO\nfor\tO\npower\tB-aspectTerm\n,\tO\nstorage\tO\n,\tO\nand\tO\nabilitiy\tO\n.\tT-0\n\nIt\tO\nhas\tO\nfar\tO\nexceeded\tO\nmy\tO\nexpectations\tO\nfor\tO\npower\tT-0\n,\tO\nstorage\tB-aspectTerm\n,\tO\nand\tO\nabilitiy\tT-1\n.\tO\n\nIt\tO\nhas\tO\nfar\tO\nexceeded\tT-3\nmy\tO\nexpectations\tT-0\nfor\tO\npower\tT-1\n,\tO\nstorage\tT-2\n,\tO\nand\tO\nabilitiy\tB-aspectTerm\n.\tT-4\n\nA\tO\ngreat\tO\nfeature\tB-aspectTerm\nis\tO\nthe\tO\nspotlight\tT-0\nsearch\tT-1\n:\tO\none\tO\ncan\tO\nsearch\tO\nfor\tO\ndocuments\tT-2\nby\tO\nsimply\tO\ntyping\tO\na\tO\nkeyword\tO\n,\tO\nrather\tO\nthan\tO\nparsing\tO\ntens\tO\nof\tO\nfile\tO\nfolders\tO\nfor\tO\na\tO\ndocument\tO\n.\tO\n\nA\tO\ngreat\tT-0\nfeature\tT-1\nis\tT-1\nthe\tT-1\nspotlight\tB-aspectTerm\nsearch\tI-aspectTerm\n:\tO\none\tO\ncan\tO\nsearch\tT-2\nfor\tT-2\ndocuments\tT-2\nby\tO\nsimply\tO\ntyping\tO\na\tO\nkeyword\tT-3\n,\tO\nrather\tO\nthan\tO\nparsing\tO\ntens\tO\nof\tO\nfile\tO\nfolders\tO\nfor\tO\na\tO\ndocument\tO\n.\tO\n\nMy\tT-0\nwireless\tB-aspectTerm\nsystem\tI-aspectTerm\nwould\tO\nnot\tO\nrecognize\tO\nWindows\tT-1\n7\tT-1\nand\tO\nI\tO\ncould\tO\nn't\tO\nget\tO\nonline\tT-2\nto\tO\nfind\tO\nout\tO\nwhy\tO\n.\tO\n\nMy\tO\nwireless\tT-0\nsystem\tT-1\nwould\tO\nnot\tO\nrecognize\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nand\tO\nI\tO\ncould\tO\nn't\tO\nget\tO\nonline\tO\nto\tO\nfind\tO\nout\tO\nwhy\tO\n.\tO\n\nSuffice\tO\nit\tO\nto\tO\nsay\tO\n,\tO\nmy\tO\nMacBook\tO\nPro\tO\nkeeps\tO\nme\tO\ngoing\tO\nwith\tO\nits\tO\nlong\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nand\tO\nblazing\tT-0\nspeed\tO\n.\tO\n\nSuffice\tO\nit\tO\nto\tO\nsay\tO\n,\tO\nmy\tO\nMacBook\tT-1\nPro\tT-1\nkeeps\tO\nme\tO\ngoing\tO\nwith\tO\nits\tO\nlong\tO\nbattery\tT-2\nlife\tT-2\nand\tO\nblazing\tT-0\nspeed\tB-aspectTerm\n.\tO\n\nThe\tO\nOS\tB-aspectTerm\nis\tO\nalso\tO\nvery\tO\nuser\tT-1\nfriendly\tT-1\n,\tO\neven\tO\nfor\tO\nthose\tO\nthat\tO\nswitch\tO\nfrom\tO\na\tO\nPC\tT-3\n,\tO\nwith\tO\na\tO\nlittle\tO\npractice\tO\nyou\tO\ncan\tO\ntake\tO\nfull\tO\nadvantage\tO\nof\tO\nthis\tO\nOS\tT-2\n!\tO\n\nThe\tO\nOS\tT-0\nis\tO\nalso\tO\nvery\tO\nuser\tO\nfriendly\tO\n,\tO\neven\tO\nfor\tO\nthose\tO\nthat\tO\nswitch\tT-1\nfrom\tO\na\tO\nPC\tT-2\n,\tO\nwith\tO\na\tO\nlittle\tO\npractice\tO\nyou\tO\ncan\tO\ntake\tO\nfull\tO\nadvantage\tO\nof\tO\nthis\tO\nOS\tB-aspectTerm\n!\tO\n\niTunes\tB-aspectTerm\nis\tO\na\tO\nhandy\tO\nmusic\tO\n-\tO\nmanagement\tT-1\nprogram\tT-1\n,\tO\nand\tO\nit\tO\nis\tO\nessential\tO\nfor\tO\nanyone\tO\nwith\tO\nan\tO\niPod\tT-2\n.\tO\n\niTunes\tO\nis\tO\na\tO\nhandy\tO\nmusic\tO\n-\tO\nmanagement\tT-0\nprogram\tB-aspectTerm\n,\tO\nand\tO\nit\tO\nis\tO\nessential\tT-1\nfor\tO\nanyone\tO\nwith\tO\nan\tO\niPod\tO\n.\tO\n\nMac\tO\nis\tO\nnot\tO\nmade\tT-0\nfor\tO\ngaming\tB-aspectTerm\n.\tO\n\nWell\tO\nI\tO\nspilled\tT-0\nsomething\tO\non\tO\nit\tO\nand\tO\nthey\tO\nreplaced\tO\nit\tO\nwith\tO\nthis\tO\nmodel\tT-2\n,\tO\nwhich\tO\ngets\tO\nhot\tT-1\nand\tO\nthe\tO\nbattery\tB-aspectTerm\ndoes\tO\nn't\tO\nmake\tO\nit\tO\nthrough\tO\n1\tO\nDVD\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nto\tO\ncall\tO\nApple\tB-aspectTerm\nsupport\tI-aspectTerm\nto\tO\nset\tO\nup\tO\nmy\tO\nnew\tO\nprinter\tT-3\nand\tO\nhave\tO\nhad\tO\nwonderful\tT-1\nexperiences\tT-2\nwith\tO\nhelpful\tT-0\n,\tO\nenglish\tO\nspeaking\tO\n(\tO\nfrom\tO\nVancouver\tO\n)\tO\ntechs\tT-4\nthat\tO\nwalked\tO\nme\tO\nthrough\tO\nthe\tO\nprocesses\tO\nto\tO\nhelp\tO\nme\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nto\tO\ncall\tO\nApple\tT-0\nsupport\tO\nto\tO\nset\tO\nup\tO\nmy\tO\nnew\tT-4\nprinter\tT-1\nand\tO\nhave\tO\nhad\tO\nwonderful\tO\nexperiences\tO\nwith\tO\nhelpful\tO\n,\tO\nenglish\tT-3\nspeaking\tT-3\n(\tO\nfrom\tO\nVancouver\tO\n)\tO\ntechs\tB-aspectTerm\nthat\tO\nwalked\tO\nme\tO\nthrough\tO\nthe\tO\nprocesses\tO\nto\tO\nhelp\tT-2\nme\tO\n.\tO\n\nBut\tO\nSony\tO\nsaid\tO\nwe\tO\ncould\tO\nsend\tT-0\nit\tT-0\nback\tT-0\nand\tO\nbe\tO\ncharged\tT-1\nfor\tO\nadding\tB-aspectTerm\nthe\tI-aspectTerm\nbluetooth\tI-aspectTerm\nan\tO\nadditional\tO\nseventy\tO\nsomething\tO\ndollars\tO\n.\tO\n\nI\tO\nneed\tO\ngraphic\tB-aspectTerm\npower\tI-aspectTerm\nto\tO\nrun\tO\nmy\tO\nAdobe\tO\nCreative\tT-0\napps\tT-1\nefficiently\tO\n.\tO\n\nI\tO\nneed\tO\ngraphic\tT-2\npower\tT-2\nto\tO\nrun\tO\nmy\tO\nAdobe\tB-aspectTerm\nCreative\tI-aspectTerm\napps\tI-aspectTerm\nefficiently\tT-1\n.\tO\n\nthe\tO\nprograms\tB-aspectTerm\nare\tO\nesay\tO\nto\tO\nuse\tO\nand\tO\nare\tO\nquick\tT-2\nto\tO\nprocess\tT-1\nthis\tO\ncomputer\tO\nworks\tO\nlike\tO\na\tO\ncharm\tT-0\n.\tO\n\nthe\tO\nprograms\tT-0\nare\tO\nesay\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nare\tO\nquick\tO\nto\tO\nprocess\tT-1\nthis\tO\ncomputer\tO\nworks\tO\nlike\tO\na\tO\ncharm\tO\n.\tO\n\nThe\tO\nmaterials\tB-aspectTerm\nthat\tO\ncame\tT-0\nwith\tT-0\nthe\tO\ncomputer\tT-1\ndid\tO\nnot\tO\ninclude\tT-2\nthe\tO\nright\tO\n#\tO\nanywhere\tO\n.\tO\n\nTech\tB-aspectTerm\nsupport\tI-aspectTerm\ntells\tO\nme\tO\nthe\tO\nlatter\tO\nproblem\tT-0\nis\tO\na\tO\npower\tO\nsupply\tO\nproblem\tT-1\nand\tO\nhave\tO\noffered\tO\nto\tO\nfix\tT-2\nit\tO\nif\tO\nit\tO\nhappens\tO\nagain\tO\n.\tO\n\nTech\tO\nsupport\tO\ntells\tO\nme\tO\nthe\tO\nlatter\tO\nproblem\tT-0\nis\tO\na\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nproblem\tO\nand\tO\nhave\tO\noffered\tO\nto\tO\nfix\tT-1\nit\tT-1\nif\tO\nit\tO\nhappens\tO\nagain\tO\n.\tO\n\nHOW\tO\nDOES\tO\nTHE\tO\nPOWER\tB-aspectTerm\nSUPPLY\tI-aspectTerm\nNOT\tO\nWORK\tO\n!\tO\n!\tO\n!\tT-0\n\nSells\tO\nfor\tO\nthe\tO\nsame\tO\nas\tO\na\tO\nnetbook\tO\nwithout\tT-0\nsacrificing\tT-1\nsize\tB-aspectTerm\n.\tO\n\nÂ\tO\nupon\tO\ngiving\tO\nthem\tO\nthe\tO\nserial\tO\nnumber\tT-0\nthe\tT-1\nfirst\tO\nthing\tO\nI\tO\nwas\tO\ntold\tO\n,\tO\nwas\tO\nthat\tO\nit\tO\nwas\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\nand\tO\nI\tO\ncould\tO\npay\tO\nto\tO\nhave\tO\nit\tO\nrepaired\tO\n.\tT-1\n\nWindows\tB-aspectTerm\nXP\tI-aspectTerm\nSP2\tI-aspectTerm\ncaused\tO\nmany\tO\nproblems\tT-1\non\tO\nthe\tO\ncomputer\tT-0\n,\tO\nso\tO\nI\tO\nhad\tO\nto\tO\nremove\tO\nit\tO\n.\tO\n\nI\tO\nreloaded\tT-1\nwith\tO\nWindows\tO\n7\tO\nUltimate\tO\n,\tO\nand\tT-0\nthe\tT-0\nBluetooth\tB-aspectTerm\nand\tO\nFingerprint\tT-2\nreader\tT-2\n(\tO\nsoftware\tO\n)\tO\nwould\tO\nnot\tO\nload\tO\n.\tO\n\nI\tO\nreloaded\tT-0\nwith\tO\nWindows\tO\n7\tO\nUltimate\tO\n,\tO\nand\tO\nthe\tO\nBluetooth\tO\nand\tO\nFingerprint\tB-aspectTerm\nreader\tI-aspectTerm\n(\tO\nsoftware\tO\n)\tO\nwould\tO\nnot\tO\nload\tO\n.\tO\n\nI\tO\nreloaded\tT-1\nwith\tO\nWindows\tO\n7\tO\nUltimate\tO\n,\tO\nand\tT-0\nthe\tO\nBluetooth\tT-2\nand\tO\nFingerprint\tT-3\nreader\tO\n(\tO\nsoftware\tB-aspectTerm\n)\tO\nwould\tO\nnot\tO\nload\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\ntechs\tB-aspectTerm\nat\tI-aspectTerm\nHP\tI-aspectTerm\nknew\tO\nwhat\tO\nthey\tT-0\nwere\tO\ndoing\tT-1\n.\tO\n\nthis\tO\nis\tO\nmy\tO\nsecond\tO\none\tO\nand\tO\nthe\tO\nsame\tO\nproblem\tO\n,\tO\nbad\tO\nvideo\tB-aspectTerm\ncard\tI-aspectTerm\nO\tO\nunreliable\tT-1\noverall\tO\n,\tO\nthis\tO\nwill\tO\nbe\tO\nmy\tO\nsecond\tT-0\ntime\tO\nreturning\tO\nthis\tO\nlaptop\tO\nback\tO\nto\tO\nbest\tO\nbuy\tO\n.\tO\n\nWith\tO\nawesome\tO\ngraphics\tT-1\nand\tO\nassuring\tT-0\nsecurity\tB-aspectTerm\n,\tO\nit\tO\n's\tO\nperfect\tO\n!\tO\n\nLaptop\tO\nwas\tO\nin\tO\nnew\tO\ncondition\tO\nand\tO\noperational\tT-2\n,\tO\nbut\tT-0\nfor\tT-0\nthe\tT-0\naudio\tB-aspectTerm\nproblem\tO\nwhen\tO\n1st\tO\nsent\tO\nfor\tO\nrepair\tO\n.\tT-1\n\nI\tO\nwas\tO\ndisappointed\tO\nwhen\tO\nI\tO\nrealized\tO\nthat\tO\nthe\tO\nkeyboard\tB-aspectTerm\ndoes\tO\nn't\tO\nlight\tO\nup\tO\non\tO\nthis\tO\nmodel\tT-0\n.\tT-1\n\nIt\tO\nruns\tB-aspectTerm\nperfectly\tT-0\n.\tO\n\nThe\tO\nlaptop\tO\nwas\tO\nvery\tT-0\neasy\tT-1\nto\tT-1\nset\tB-aspectTerm\nup\tI-aspectTerm\n.\tO\n\nÂ\tO\nSometimes\tO\nthe\tT-0\nscreen\tB-aspectTerm\neven\tO\ngoes\tO\nblack\tO\non\tO\nthis\tO\ncomputer\tO\n.\tT-1\n\nI\tT-0\nrecommend\tT-0\nfor\tT-0\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\nand\tO\ninternet\tT-1\nusers\tT-1\n.\tO\n\nSince\tT-0\nI\tT-0\n've\tT-0\nhad\tT-0\nthis\tT-0\ncomputer\tT-0\nI\tT-0\n've\tT-0\nonly\tT-0\nused\tT-0\nthe\tT-0\ntrackpad\tB-aspectTerm\nbecause\tO\nit\tT-1\nis\tT-1\nso\tT-1\nnice\tT-1\nand\tT-1\nsmooth\tT-1\n.\tO\n\nA\tT-0\nlonger\tT-0\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwould\tO\nhave\tO\nbeen\tO\ngreat\tO\n-\tO\nbut\tO\nit\tO\nmeets\tO\nit\tO\n's\tO\nspec\tO\nquite\tO\neasily\tT-1\n.\tO\n\nA\tO\nlonger\tT-1\nbattery\tT-1\nlife\tT-1\nwould\tO\nhave\tO\nbeen\tO\ngreat\tO\n-\tO\nbut\tO\nit\tO\nmeets\tO\nit\tO\n's\tO\nspec\tB-aspectTerm\nquite\tO\neasily\tO\n.\tT-0\n\nWho\tO\ncould\tO\nn't\tO\nlove\tO\na\tO\nDVD\tB-aspectTerm\nburner\tI-aspectTerm\n,\tO\n80-gigabyte\tT-1\nHD\tO\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tO\nchip\tO\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tT-0\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tO\nand\tO\nToshiba\tO\nmachines\tO\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tO\n-\tO\nquality\tO\ncomponents\tO\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tT-1\n\nWho\tO\ncould\tO\nn't\tO\nlove\tO\na\tO\nDVD\tO\nburner\tO\n,\tO\n80-gigabyte\tT-0\nHD\tB-aspectTerm\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tO\nchip\tO\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tO\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tO\nand\tO\nToshiba\tO\nmachines\tO\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tO\n-\tO\nquality\tO\ncomponents\tO\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tO\n\nWho\tO\ncould\tT-0\nn't\tO\nlove\tO\na\tO\nDVD\tT-1\nburner\tT-1\n,\tO\n80-gigabyte\tT-2\nHD\tT-2\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tB-aspectTerm\nchip\tI-aspectTerm\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tO\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tT-3\nand\tO\nToshiba\tT-4\nmachines\tT-5\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tO\n-\tO\nquality\tO\ncomponents\tO\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tO\n\nWho\tO\ncould\tO\nn't\tO\nlove\tO\na\tO\nDVD\tO\nburner\tO\n,\tO\n80-gigabyte\tO\nHD\tO\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tT-0\nchip\tO\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tO\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tO\nand\tO\nToshiba\tO\nmachines\tO\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tT-1\n-\tT-1\nquality\tT-1\ncomponents\tB-aspectTerm\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tO\n\nIts\tO\nfast\tT-0\nand\tO\nanother\tO\nthing\tT-2\nI\tO\nlike\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\nthree\tT-1\nUSB\tB-aspectTerm\nports\tI-aspectTerm\n.\tO\n\nThe\tO\nsalesman\tT-1\ntalked\tO\nus\tO\ninto\tO\nthis\tO\ncomputer\tO\naway\tO\nfrom\tO\nanother\tO\nwe\tO\nwere\tO\nlooking\tO\nat\tO\nand\tO\nwe\tT-0\nhave\tT-0\nhad\tT-0\nnothing\tT-0\nbut\tT-0\nproblems\tT-0\nwith\tT-0\nsoftware\tB-aspectTerm\nproblems\tO\nand\tO\njust\tO\nnot\tO\nhappy\tO\nwith\tO\nit\tO\n.\tO\n\nThat\tO\nsystem\tB-aspectTerm\nis\tO\nfixed\tT-0\n.\tO\n\nLike\tT-0\nthe\tO\nprice\tB-aspectTerm\nand\tO\noperation\tO\n.\tO\n\nLike\tO\nthe\tO\nprice\tO\nand\tO\noperation\tB-aspectTerm\n.\tT-0\n\nThe\tO\nbrand\tB-aspectTerm\nis\tO\ntarnished\tO\nin\tO\nmy\tO\nheart\tT-0\n.\tO\n\nThis\tO\nis\tO\nlikely\tO\ndue\tO\nto\tO\npoor\tO\ngrounding\tT-1\nand\tO\nisolation\tT-2\nbetween\tT-0\nthe\tO\ncomponents\tB-aspectTerm\n,\tO\nand\tO\nI\tO\n'm\tO\nhoping\tO\nthat\tO\nit\tO\ncan\tO\nbe\tO\nfixed\tO\nwith\tO\na\tO\nground\tT-3\nloop\tT-3\nisolator\tT-3\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tO\nbetter\tO\nproduct\tO\nquality\tO\nfor\tO\nthis\tO\nprice\tO\nrange\tO\n.\tO\n\nThis\tO\nis\tO\nlikely\tO\ndue\tO\nto\tO\npoor\tO\ngrounding\tT-2\nand\tT-2\nisolation\tT-2\nbetween\tO\nthe\tO\ncomponents\tT-3\n,\tO\nand\tT-0\nI\tT-0\n'm\tT-0\nhoping\tT-0\nthat\tT-0\nit\tT-0\ncan\tT-0\nbe\tT-0\nfixed\tT-0\nwith\tT-0\na\tT-0\nground\tB-aspectTerm\nloop\tI-aspectTerm\nisolator\tI-aspectTerm\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tO\nbetter\tO\nproduct\tO\nquality\tO\nfor\tO\nthis\tO\nprice\tO\nrange\tT-1\n.\tO\n\nThis\tO\nis\tO\nlikely\tT-2\ndue\tO\nto\tO\npoor\tO\ngrounding\tO\nand\tO\nisolation\tO\nbetween\tO\nthe\tO\ncomponents\tT-0\n,\tO\nand\tO\nI\tO\n'm\tO\nhoping\tO\nthat\tO\nit\tO\ncan\tO\nbe\tO\nfixed\tO\nwith\tO\na\tO\nground\tT-1\nloop\tT-1\nisolator\tT-1\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tT-3\nbetter\tO\nproduct\tO\nquality\tB-aspectTerm\nfor\tO\nthis\tO\nprice\tO\nrange\tO\n.\tO\n\nThis\tO\nis\tO\nlikely\tO\ndue\tO\nto\tO\npoor\tO\ngrounding\tT-0\nand\tO\nisolation\tT-1\nbetween\tO\nthe\tO\ncomponents\tO\n,\tO\nand\tO\nI\tO\n'm\tO\nhoping\tO\nthat\tO\nit\tO\ncan\tO\nbe\tO\nfixed\tO\nwith\tO\na\tO\nground\tO\nloop\tO\nisolator\tT-2\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tO\nbetter\tO\nproduct\tO\nquality\tO\nfor\tO\nthis\tO\nprice\tB-aspectTerm\nrange\tI-aspectTerm\n.\tO\n\nI\tO\n'\tO\nhave\tO\nhad\tO\nit\tO\nfor\tO\nabout\tO\na\tO\n1\tO\n1/2\tO\nand\tO\nyes\tO\nI\tO\nhave\tO\nhad\tO\nan\tO\nissue\tO\nwith\tO\nit\tO\none\tO\nmonth\tO\nout\tT-0\nof\tT-0\nwarranty\tB-aspectTerm\n.\tT-1\n\nOnce\tO\nopen\tT-0\n,\tO\nthe\tO\nleading\tB-aspectTerm\nedge\tI-aspectTerm\nis\tO\nrazor\tT-1\nsharp\tO\n.\tO\n\nLoaded\tT-0\nwith\tO\nbloatware\tB-aspectTerm\n.\tO\n\nMaximum\tB-aspectTerm\nsound\tI-aspectTerm\nis\tO\nn't\tO\nnearly\tO\nas\tO\nloud\tT-0\nas\tO\nit\tO\nshould\tO\nbe\tO\n.\tT-1\n\nI\tO\nloaded\tT-0\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nvia\tO\nBootcamp\tO\nand\tO\nit\tO\nworks\tT-1\nflawlessly\tT-2\n!\tO\n\nI\tO\nloaded\tT-0\nwindows\tT-2\n7\tO\nvia\tO\nBootcamp\tB-aspectTerm\nand\tO\nit\tO\nworks\tT-1\nflawlessly\tO\n!\tO\n\nGreat\tO\nLaptop\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n,\tO\nworks\tT-0\nwell\tT-0\nwith\tO\naction\tO\npack\tO\ngames\tO\n.\tO\n\nGreat\tO\nLaptop\tT-1\nfor\tO\nthe\tO\nprice\tT-2\n,\tO\nworks\tB-aspectTerm\nwell\tO\nwith\tO\naction\tO\npack\tO\ngames\tT-3\n.\tT-0\n\nGreat\tT-2\nLaptop\tO\nfor\tO\nthe\tO\nprice\tT-1\n,\tO\nworks\tT-0\nwell\tT-0\nwith\tT-0\naction\tB-aspectTerm\npack\tI-aspectTerm\ngames\tI-aspectTerm\n.\tO\n\nAlthough\tO\nthe\tO\nprice\tB-aspectTerm\nis\tO\nhigher\tT-2\nthen\tO\nDell\tO\nlaptops\tO\n,\tO\nthe\tO\nMacbooks\tT-1\nare\tO\nworth\tO\nthe\tO\ndough\tT-0\n.\tO\n\nI\tO\nwould\tO\nnot\tO\nrecommend\tT-0\nthis\tO\nto\tO\nanyone\tO\nwanting\tO\na\tO\nnotebook\tT-1\nexpecting\tO\nthe\tO\nperformance\tB-aspectTerm\nof\tO\na\tO\nDesktop\tO\nit\tO\ndoes\tO\nnot\tO\nmeet\tO\nthe\tO\nexpectations\tO\n.\tO\n\nThe\tT-0\nMacbook\tT-0\narrived\tT-0\nin\tT-0\na\tT-0\nnice\tT-0\ntwin\tB-aspectTerm\npacking\tI-aspectTerm\nand\tO\nsealed\tT-1\nin\tO\nthe\tO\nbox\tO\n,\tO\nall\tO\nthe\tO\nfunctions\tO\nworks\tO\ngreat\tO\n.\tO\n\nThe\tO\nMacbook\tO\narrived\tO\nin\tO\na\tO\nnice\tT-1\ntwin\tO\npacking\tT-2\nand\tO\nsealed\tT-0\nin\tO\nthe\tO\nbox\tO\n,\tO\nall\tO\nthe\tO\nfunctions\tB-aspectTerm\nworks\tO\ngreat\tO\n.\tO\n\nSo\tO\nwhat\tO\nif\tO\nthe\tO\nlaptops\tT-1\n/\tO\nmobile\tT-2\nphones\tT-0\nlook\tB-aspectTerm\nchic\tO\nand\tO\ncool\tO\n?\tO\nThe\tO\nafter\tO\nsales\tO\nsupport\tO\nis\tO\nterrible\tO\n.\tO\n\nSo\tO\nwhat\tO\nif\tO\nthe\tO\nlaptops\tT-0\n/\tO\nmobile\tT-1\nphones\tT-1\nlook\tO\nchic\tT-2\nand\tO\ncool\tT-3\n?\tO\nThe\tO\nafter\tB-aspectTerm\nsales\tI-aspectTerm\nsupport\tI-aspectTerm\nis\tO\nterrible\tO\n.\tT-4\n\nI\tO\nhate\tO\nthe\tO\ndisplay\tB-aspectTerm\nscreen\tI-aspectTerm\nand\tO\nI\tO\nhave\tO\ndone\tO\neverything\tO\nI\tO\ncould\tO\ndo\tO\nthe\tO\nchange\tT-0\nit\tT-0\n.\tO\n\nI\tO\nalso\tO\nlike\tO\nthe\tO\nacer\tB-aspectTerm\narcade\tI-aspectTerm\nbut\tO\nthese\tT-0\nwere\tO\nreallythe\tO\nonly\tO\ntwo\tO\nthings\tT-1\nI\tO\nliked\tT-2\nabout\tO\nthis\tO\nlaptop\tT-3\n.\tO\n\nHave\tO\nnot\tO\nyet\tO\nneeded\tO\nany\tO\ncustomer\tB-aspectTerm\nsupport\tI-aspectTerm\nwith\tO\nthis\tO\nyet\tO\nso\tO\nto\tO\nme\tO\nthat\tO\nis\tO\na\tO\ngreat\tO\nthing\tO\n,\tO\nwhich\tO\nis\tO\nleaps\tT-0\nand\tT-0\nbounds\tT-0\nahead\tT-0\nof\tO\nPC\tO\nin\tO\nmy\tO\nopinion\tO\n.\tO\n\nI\tO\ngave\tO\nit\tO\nto\tO\nmy\tO\ndaughter\tO\nbecause\tO\nI\tO\njust\tO\nhated\tO\nthe\tO\nscreen\tB-aspectTerm\n,\tO\nhated\tO\nthat\tO\nit\tO\nhad\tO\nno\tO\ncd\tO\ndrive\tO\nto\tO\nat\tO\nleast\tO\nplay\tT-1\ncd\tT-0\n's\tT-0\nwhen\tO\nI\tO\nwanted\tO\nto\tO\nlisten\tO\nto\tO\nmusic\tO\nand\tO\ndo\tO\nschoolwork\tO\n.\tO\n\nI\tO\ngave\tO\nit\tO\nto\tO\nmy\tO\ndaughter\tO\nbecause\tT-1\nI\tO\njust\tO\nhated\tO\nthe\tO\nscreen\tO\n,\tO\nhated\tT-0\nthat\tO\nit\tO\nhad\tO\nno\tO\ncd\tB-aspectTerm\ndrive\tI-aspectTerm\nto\tO\nat\tO\nleast\tO\nplay\tO\ncd\tO\n's\tO\nwhen\tO\nI\tO\nwanted\tO\nto\tO\nlisten\tO\nto\tO\nmusic\tO\nand\tO\ndo\tO\nschoolwork\tO\n.\tO\n\nIt\tO\nruns\tB-aspectTerm\nvery\tO\nquiet\tT-0\ntoo\tO\nwhich\tO\nis\tO\na\tO\nplus\tO\n.\tO\n\nIt\tO\nwas\tO\nheavy\tO\n,\tO\nbulky\tO\n,\tO\nand\tO\nhard\tO\nto\tO\ncarry\tO\nbecause\tT-0\nof\tO\nthe\tO\nsize\tB-aspectTerm\n.\tO\n\nThe\tO\ngames\tB-aspectTerm\nincluded\tT-0\nare\tO\nvery\tO\ngood\tO\ngames\tO\n.\tO\n\nThe\tO\ngames\tT-1\nincluded\tT-0\nare\tO\nvery\tO\ngood\tO\ngames\tB-aspectTerm\n.\tO\n\nthis\tO\ncomputer\tT-0\nwill\tO\nlast\tO\nyou\tO\nat\tO\nleast\tO\n7\tO\nyears\tO\n,\tO\nthat\tO\ns\tO\nan\tO\namazing\tO\nlife\tB-aspectTerm\nspanned\tT-2\nan\tO\nelectronic\tT-1\n.\tO\n\nSometimes\tO\nyou\tO\nreally\tO\nhave\tT-0\nto\tT-0\ntap\tT-1\nthe\tT-1\npad\tB-aspectTerm\nto\tO\nget\tO\nit\tO\nto\tO\nworki\tO\n\nIt\tO\n's\tO\nsuper\tO\nfast\tO\nand\tO\na\tO\ngreat\tO\nvalue\tB-aspectTerm\nfor\tO\nthe\tO\nprice\tT-0\n!\tO\n\nIt\tO\n's\tO\nsuper\tO\nfast\tT-0\nand\tO\na\tO\ngreat\tO\nvalue\tT-1\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n!\tO\n\nThree\tO\n,\tO\nthe\tO\nmac\tO\nbook\tO\nhas\tO\nadvantages\tT-1\nover\tO\npcs\tO\n'\tO\nwith\tO\nlinux\tB-aspectTerm\nbased\tI-aspectTerm\nos\tI-aspectTerm\nthere\tO\nis\tO\nvery\tO\n'\tO\nfew\tO\nproblems\tO\nwith\tO\nsystem\tT-0\nperformance\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\na\tO\nmac\tO\n.\tO\n\nThree\tO\n,\tO\nthe\tO\nmac\tO\nbook\tO\nhas\tO\nadvantages\tO\nover\tO\npcs\tO\n'\tO\nwith\tO\nlinux\tO\nbased\tO\nos\tO\nthere\tO\nis\tO\nvery\tO\n'\tO\nfew\tT-0\nproblems\tT-0\nwith\tO\nsystem\tB-aspectTerm\nperformance\tI-aspectTerm\nwhen\tO\nit\tO\ncomes\tO\nto\tO\na\tO\nmac\tO\n.\tO\n\nA\tO\nmac\tT-0\nis\tO\nvery\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nit\tO\nsimply\tT-1\nmakes\tO\nsense\tO\n.\tO\n\nhowever\tO\n,\tO\nI\tO\nmay\tO\nhave\tO\ninadvertently\tO\nthrown\tT-0\nout\tT-0\none\tO\nof\tO\nthe\tO\nbatteries\tB-aspectTerm\nwith\tO\nthe\tO\nshipping\tT-1\ncarton\tT-1\n.\tO\n\nhowever\tO\n,\tO\nI\tO\nmay\tO\nhave\tO\ninadvertently\tO\nthrown\tT-0\nout\tO\none\tO\nof\tO\nthe\tO\nbatteries\tT-1\nwith\tO\nthe\tO\nshipping\tB-aspectTerm\ncarton\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nso\tO\nmuch\tO\neasier\tT-0\nto\tO\nuse\tB-aspectTerm\n\nThere\tO\nis\tO\nno\tO\nneed\tO\nto\tO\nopen\tO\na\tO\nprogram\tB-aspectTerm\nfirst\tO\nand\tO\nthe\tO\ncliick\tT-0\nopen\tT-1\nor\tO\nimport\tT-2\n.\tO\n\nIt\tO\nis\tO\nso\tO\nnice\tO\nnot\tO\nto\tO\nworry\tT-0\nabout\tT-0\nthat\tO\nand\tO\nthe\tO\nextra\tO\nexpense\tT-1\nthat\tO\ncomes\tO\nalong\tO\nwith\tO\nthe\tO\nnecessary\tO\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\non\tO\nPC\tT-2\n's\tT-2\n.\tO\n\nThree\tO\nweeks\tO\nafter\tO\nI\tO\nbought\tO\nthe\tO\nnetbook\tT-1\n,\tO\nthe\tO\nscreen\tB-aspectTerm\nquit\tO\nworking\tT-0\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tO\nOSX\tO\n16\tO\nfunctions\tO\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tT-0\nare\tO\nrouted\tT-2\nthrough\tO\nthe\tO\nhardware\tT-1\nrather\tO\nthan\tO\nthe\tO\nsoftware\tT-3\n.\tO\n\nThe\tO\nprocessor\tT-1\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tT-0\nthat\tO\nApple\tO\nOSX\tB-aspectTerm\n16\tI-aspectTerm\nfunctions\tO\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tT-2\nare\tO\nrouted\tO\nthrough\tO\nthe\tO\nhardware\tT-3\nrather\tO\nthan\tO\nthe\tO\nsoftware\tO\n.\tO\n\nThe\tO\nprocessor\tT-0\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tO\nOSX\tO\n16\tO\nfunctions\tT-2\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tB-aspectTerm\nare\tO\nrouted\tT-4\nthrough\tO\nthe\tO\nhardware\tT-1\nrather\tO\nthan\tO\nthe\tO\nsoftware\tT-3\n.\tO\n\nThe\tO\nprocessor\tT-0\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tT-1\nOSX\tT-1\n16\tT-1\nfunctions\tO\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tO\nare\tO\nrouted\tO\nthrough\tO\nthe\tO\nhardware\tB-aspectTerm\nrather\tO\nthan\tO\nthe\tO\nsoftware\tT-2\n.\tO\n\nThe\tO\nprocessor\tT-1\nscreams\tO\n,\tO\nand\tO\nbecause\tT-0\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tO\nOSX\tO\n16\tO\nfunctions\tT-2\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tO\nare\tO\nrouted\tT-3\nthrough\tO\nthe\tO\nhardware\tO\nrather\tO\nthan\tO\nthe\tO\nsoftware\tB-aspectTerm\n.\tO\n\nI\tO\nwanted\tO\nsomething\tO\nthat\tO\nhad\tT-2\na\tO\nnew\tT-3\nIntel\tB-aspectTerm\nCore\tI-aspectTerm\nprocessors\tI-aspectTerm\nand\tO\nHDMI\tO\nport\tO\nso\tO\nthat\tO\nwe\tO\ncould\tO\nhook\tT-0\nit\tT-0\nup\tT-0\ndirectly\tO\nto\tT-1\nour\tT-1\nTV\tT-1\n.\tO\n\nI\tO\nwanted\tT-0\nsomething\tO\nthat\tO\nhad\tO\na\tO\nnew\tO\nIntel\tO\nCore\tO\nprocessors\tO\nand\tO\nHDMI\tB-aspectTerm\nport\tI-aspectTerm\nso\tO\nthat\tO\nwe\tO\ncould\tO\nhook\tT-1\nit\tO\nup\tT-2\ndirectly\tO\nto\tO\nour\tO\nTV\tT-3\n.\tO\n\nThe\tO\nApple\tO\nwill\tO\nrun\tT-0\nInternet\tB-aspectTerm\nExplorer\tI-aspectTerm\n,\tO\nbut\tO\nat\tO\nan\tO\namazingly\tO\nslow\tO\nrate\tO\n.\tO\n\nWith\tO\ntoday\tO\n's\tO\ncompany\tO\nfighting\tO\nover\tO\nmarketshare\tO\n,\tO\nits\tO\na\tO\nshame\tT-1\nthat\tO\nASUS\tO\ncan\tO\nget\tO\naway\tO\nwith\tO\nthe\tO\ninept\tO\nstaff\tB-aspectTerm\nanswering\tT-0\nthephone\tT-0\n.\tO\n\nThe\tO\nprice\tB-aspectTerm\npremium\tI-aspectTerm\nis\tO\na\tO\nlittle\tT-0\nmuch\tT-0\n,\tO\nbut\tO\nwhen\tO\nyou\tO\nstart\tO\nlooking\tO\nat\tO\nthe\tO\nfeatures\tT-1\nit\tO\nis\tO\nworth\tO\nthe\tO\nadded\tO\ncash\tO\n.\tO\n\nThe\tO\nprice\tT-1\npremium\tT-1\nis\tO\na\tO\nlittle\tO\nmuch\tO\n,\tO\nbut\tO\nwhen\tO\nyou\tO\nstart\tO\nlooking\tO\nat\tO\nthe\tO\nfeatures\tB-aspectTerm\nit\tO\nis\tO\nworth\tO\nthe\tO\nadded\tT-0\ncash\tO\n.\tO\n\nMicrosoft\tB-aspectTerm\nword\tI-aspectTerm\nwas\tO\nnot\tO\non\tT-0\nit\tO\nandI\tO\nhad\tO\nto\tO\nbuy\tO\nit\tO\nseperately\tT-1\n.\tO\n\nit\tO\nhas\tO\n3\tT-1\nusb\tB-aspectTerm\nports\tI-aspectTerm\n,\tO\n1\tO\nsd\tO\nmemory\tO\ncard\tO\nreader\tO\nand\tO\nan\tO\nsd\tO\nmemory\tO\ncar\tO\nexpansion\tT-0\n.\tO\n\nit\tO\nhas\tO\n3\tO\nusb\tO\nports\tO\n,\tO\n1\tT-3\nsd\tB-aspectTerm\nmemory\tI-aspectTerm\ncard\tI-aspectTerm\nreader\tI-aspectTerm\nand\tO\nan\tO\nsd\tO\nmemory\tT-1\ncar\tO\nexpansion\tT-2\n.\tT-0\n\nit\tO\nhas\tO\n3\tO\nusb\tT-0\nports\tO\n,\tO\n1\tT-1\nsd\tT-1\nmemory\tT-1\ncard\tT-1\nreader\tT-1\nand\tO\nan\tO\nsd\tB-aspectTerm\nmemory\tI-aspectTerm\ncar\tI-aspectTerm\nexpansion\tI-aspectTerm\n.\tO\n\nI\tO\nconnect\tT-1\na\tO\nLaCie\tB-aspectTerm\n2Big\tI-aspectTerm\nexternal\tI-aspectTerm\ndrive\tI-aspectTerm\nvia\tO\nthe\tO\nfirewire\tT-2\n800\tT-2\ninterface\tT-2\n,\tO\nwhich\tT-0\nis\tO\nuseful\tO\nfor\tO\nTime\tT-3\nMachine\tT-3\n.\tO\n\nI\tO\nconnect\tT-0\na\tO\nLaCie\tO\n2Big\tO\nexternal\tT-2\ndrive\tT-3\nvia\tO\nthe\tO\nfirewire\tB-aspectTerm\n800\tI-aspectTerm\ninterface\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\nuseful\tO\nfor\tO\nTime\tT-1\nMachine\tT-1\n.\tO\n\nI\tO\nconnect\tT-0\na\tO\nLaCie\tT-1\n2Big\tT-1\nexternal\tT-1\ndrive\tT-1\nvia\tO\nthe\tO\nfirewire\tT-2\n800\tT-2\ninterface\tO\n,\tO\nwhich\tO\nis\tO\nuseful\tT-3\nfor\tT-3\nTime\tB-aspectTerm\nMachine\tI-aspectTerm\n.\tO\n\nMy\tO\nToshiba\tT-0\ndid\tO\nnot\tO\nhave\tO\nsound\tB-aspectTerm\non\tO\neverything\tO\n,\tO\njust\tO\ncertain\tO\nthings\tO\n.\tO\n\nI\tO\nam\tO\noverall\tO\nvery\tO\npleased\tO\nwith\tO\nmy\tO\ntoshiba\tT-1\nsatellite\tT-2\n,\tO\nI\tO\nlike\tO\nthe\tO\nextra\tB-aspectTerm\nfeatures\tI-aspectTerm\n,\tO\nI\tO\nlove\tO\nthe\tO\nwindows\tT-0\n7\tO\nhome\tO\npremium\tT-3\n.\tO\n\nI\tO\nam\tO\noverall\tO\nvery\tO\npleased\tO\nwith\tO\nmy\tO\ntoshiba\tO\nsatellite\tO\n,\tO\nI\tO\nlike\tO\nthe\tO\nextra\tT-0\nfeatures\tO\n,\tO\nI\tO\nlove\tO\nthe\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nhome\tI-aspectTerm\npremium\tI-aspectTerm\n.\tO\n\nThe\tO\nAspire\tO\nwo\tO\nnt\tO\neven\tO\nboot\tB-aspectTerm\npast\tT-1\nthe\tT-1\nAcer\tO\nscreen\tO\nwith\tO\na\tO\nDroid\tO\n(\tO\nI\tO\nhave\tO\ntried\tO\nboth\tO\nMotorola\tO\nand\tO\nHTC\tO\n)\tO\nplugged\tT-2\ninto\tO\nthe\tO\nUSB\tO\nport\tO\n.\tT-0\n\nThe\tO\nAspire\tT-0\nwo\tO\nnt\tO\neven\tO\nboot\tO\npast\tT-3\nthe\tO\nAcer\tB-aspectTerm\nscreen\tI-aspectTerm\nwith\tO\na\tO\nDroid\tO\n(\tO\nI\tO\nhave\tO\ntried\tO\nboth\tO\nMotorola\tO\nand\tO\nHTC\tO\n)\tO\nplugged\tT-2\ninto\tO\nthe\tO\nUSB\tT-1\nport\tT-1\n.\tO\n\nThe\tO\nAspire\tO\nwo\tO\nnt\tO\neven\tO\nboot\tT-1\npast\tO\nthe\tO\nAcer\tO\nscreen\tO\nwith\tO\na\tO\nDroid\tO\n(\tO\nI\tO\nhave\tO\ntried\tO\nboth\tO\nMotorola\tO\nand\tO\nHTC\tO\n)\tO\nplugged\tT-0\ninto\tT-0\nthe\tO\nUSB\tB-aspectTerm\nport\tI-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwas\tO\nshorter\tT-0\nthan\tO\nexpected\tO\n.\tO\n\nIt\tO\nfires\tB-aspectTerm\nup\tI-aspectTerm\nin\tO\nthe\tO\nmorning\tO\nin\tO\nless\tO\nthan\tO\n30\tO\nseconds\tT-1\nand\tO\nI\tO\nhave\tO\nnever\tO\nhad\tO\nany\tO\nissues\tO\nwith\tO\nit\tO\nfreezing\tT-0\n.\tO\n\nThe\tT-1\nkeyboard\tB-aspectTerm\nis\tT-2\ntop\tT-2\nnotch\tT-2\n.\tT-0\n\nIt\tO\ndrives\tO\nme\tO\ncrazy\tO\nwhen\tO\nI\tO\nwant\tO\nto\tO\ndownload\tO\na\tO\ngame\tO\nor\tO\nsomething\tO\nof\tO\nthat\tO\nnature\tT-0\nand\tO\nI\tO\nca\tO\nn't\tO\nplay\tO\nit\tO\nbecause\tO\nits\tO\nnot\tO\ncompatable\tT-1\nwith\tO\nthe\tO\nsoftware\tB-aspectTerm\n.\tO\n\nThe\tO\nonline\tB-aspectTerm\ntutorial\tI-aspectTerm\nvideos\tI-aspectTerm\nmake\tO\nit\tO\nsuper\tO\neasy\tT-1\nto\tT-1\nlearn\tT-1\nif\tO\nyou\tO\nhave\tO\nalways\tO\nused\tT-0\na\tO\nPC\tO\n.\tO\n\nThe\tO\nimage\tB-aspectTerm\nis\tO\ngreat\tT-0\n,\tO\nand\tO\nthe\tO\nsoud\tT-2\nis\tO\nexcelent\tT-1\n.\tO\n\nThe\tO\nimage\tO\nis\tO\ngreat\tO\n,\tO\nand\tO\nthe\tO\nsoud\tB-aspectTerm\nis\tO\nexcelent\tT-0\n.\tO\n\nWith\tO\na\tO\nMAC\tO\ncomputer\tO\nI\tO\nhave\tO\nmore\tO\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tT-2\nto\tO\nwait\tT-1\nfor\tT-1\nwindows\tB-aspectTerm\nto\tT-0\nboot\tT-0\nup\tT-0\nor\tT-0\nshut\tT-0\ndown\tT-0\nand\tO\nall\tO\nthe\tO\nviruses\tO\nassociated\tO\nwith\tO\nwindows\tO\n.\tO\n\nWith\tO\na\tO\nMAC\tO\ncomputer\tO\nI\tO\nhave\tO\nmore\tT-3\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nwait\tO\nfor\tO\nwindows\tT-0\nto\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nor\tO\nshut\tT-1\ndown\tT-1\nand\tO\nall\tO\nthe\tO\nviruses\tT-2\nassociated\tO\nwith\tO\nwindows\tO\n.\tO\n\nWith\tO\na\tO\nMAC\tO\ncomputer\tO\nI\tO\nhave\tO\nmore\tT-0\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nwait\tO\nfor\tO\nwindows\tO\nto\tO\nboot\tO\nup\tO\nor\tO\nshut\tB-aspectTerm\ndown\tI-aspectTerm\nand\tO\nall\tO\nthe\tO\nviruses\tO\nassociated\tO\nwith\tO\nwindows\tO\n.\tO\n\nWith\tO\na\tO\nMAC\tT-0\ncomputer\tT-0\nI\tO\nhave\tO\nmore\tO\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nwait\tO\nfor\tO\nwindows\tT-1\nto\tO\nboot\tO\nup\tO\nor\tO\nshut\tO\ndown\tO\nand\tO\nall\tO\nthe\tO\nviruses\tT-2\nassociated\tO\nwith\tO\nwindows\tB-aspectTerm\n.\tO\n\nIt\tO\nwas\tO\nvery\tO\neasy\tO\nto\tO\njust\tO\npick\tT-1\nup\tT-1\nand\tO\nuse--\tB-aspectTerm\nIt\tO\ndid\tO\nnot\tO\ntake\tO\nlong\tO\nto\tO\nget\tO\nused\tO\nto\tO\nthe\tO\nMac\tO\nOS\tO\n.\tT-0\n\nIt\tO\nwas\tO\nvery\tO\neasy\tO\nto\tO\njust\tO\npick\tO\nup\tO\nand\tO\nuse--\tO\nIt\tO\ndid\tO\nnot\tO\ntake\tO\nlong\tO\nto\tO\nget\tT-0\nused\tT-0\nto\tT-0\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nwell\tO\nworth\tO\nthe\tO\nmoney\tT-1\nit\tO\ncost\tB-aspectTerm\n,\tO\nVery\tO\ngood\tO\ninvestment\tT-2\n.\tT-0\n\nUpgrading\tT-2\nfrom\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nStarter\tI-aspectTerm\n,\tO\nthru\tO\nWindows\tT-0\n7\tT-0\nHome\tT-0\nPremium\tT-0\n,\tO\nto\tO\nWindows\tT-1\n7\tT-1\nProfessional\tT-1\nwas\tO\na\tO\nsnap\tO\n;\tO\n\nUpgrading\tT-0\nfrom\tO\nWindows\tO\n7\tO\nStarter\tT-2\n,\tO\nthru\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nHome\tI-aspectTerm\nPremium\tI-aspectTerm\n,\tO\nto\tO\nWindows\tO\n7\tO\nProfessional\tT-1\nwas\tO\na\tO\nsnap\tO\n;\tT-1\n\nUpgrading\tT-0\nfrom\tO\nWindows\tO\n7\tO\nStarter\tO\n,\tO\nthru\tO\nWindows\tO\n7\tO\nHome\tO\nPremium\tO\n,\tO\nto\tT-1\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nProfessional\tI-aspectTerm\nwas\tO\na\tO\nsnap\tO\n;\tO\n\nMy\tO\nkids\tO\n(\tO\nand\tO\ndogs\tT-0\n)\tO\ndestroyed\tO\ntwo\tO\npower\tB-aspectTerm\ncords\tI-aspectTerm\nby\tO\npulling\tT-1\non\tT-1\nthem\tT-1\n.\tO\n\nI\tO\nhad\tO\nupgraded\tT-1\nmy\tO\nold\tO\nMacBook\tO\nto\tO\nLion\tO\n,\tO\nso\tO\nI\tO\nkind\tO\nof\tO\nknew\tO\nwhat\tO\nI\tO\nwas\tO\ngetting\tO\n,\tO\nbut\tO\nhad\tO\nn't\tO\nbeen\tO\nable\tO\nto\tO\nenjoy\tO\nsome\tO\nof\tO\nthe\tO\nawesome\tO\nnew\tT-0\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\nfeatures\tI-aspectTerm\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\na\tT-1\nlittle\tT-1\nglary\tT-1\n,\tO\nand\tO\nI\tO\nhated\tO\nthe\tO\nclicking\tT-2\nbuttons\tT-2\n,\tO\nbut\tO\nI\tO\ngot\tO\nused\tO\nto\tO\nthem\tO\n.\tO\n\nThe\tO\nscreen\tO\nis\tO\na\tO\nlittle\tO\nglary\tT-0\n,\tO\nand\tO\nI\tO\nhated\tO\nthe\tO\nclicking\tB-aspectTerm\nbuttons\tI-aspectTerm\n,\tO\nbut\tO\nI\tO\ngot\tO\nused\tO\nto\tO\nthem\tO\n.\tO\n\nnot\tT-0\nusing\tT-0\nwired\tB-aspectTerm\nlan\tI-aspectTerm\nnot\tO\nsure\tO\nwhat\tO\nthat\tO\ns\tO\nabout\tO\n.\tO\n\nThe\tO\nmacbook\tO\nrarely\tT-0\nrequires\tT-1\na\tT-1\nhard\tB-aspectTerm\nreboot\tI-aspectTerm\n.\tO\n\nNow\tO\nfor\tO\nthe\tO\nhardware\tB-aspectTerm\nproblems\tT-0\n.\tO\n\nAnyways\tO\nI\tO\nbought\tO\nthis\tO\ntwo\tO\nmonths\tO\nago\tO\nand\tO\nwhen\tO\nI\tO\nfirst\tO\nbrought\tO\nit\tO\nhome\tT-0\nit\tO\nkept\tO\ngiving\tO\nme\tO\na\tO\nmessage\tT-1\nabout\tO\na\tO\nvibration\tT-2\nin\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nit\tO\nis\tO\nputting\tO\nit\tO\ntemporaly\tO\nin\tO\nsave\tT-3\nzone\tT-3\n.\tO\n\nIt\tO\n's\tO\nfast\tO\nand\tO\nhas\tO\nexcellent\tT-1\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tT-0\n\nFeatures\tB-aspectTerm\nlike\tO\nthe\tO\nfont\tT-1\nare\tO\nvery\tO\nblock\tT-0\n-\tO\nlike\tO\nand\tO\nold\tO\nschool\tO\n.\tO\n\nFeatures\tO\nlike\tO\nthe\tO\nfont\tB-aspectTerm\nare\tO\nvery\tO\nblock\tT-0\n-\tT-0\nlike\tT-0\nand\tO\nold\tT-1\nschool\tT-1\n.\tT-1\n\nIt\tO\nis\tO\nloaded\tT-1\nwith\tT-1\nprograms\tB-aspectTerm\nthat\tO\nis\tO\nof\tO\nno\tO\ngood\tO\nfor\tO\nthe\tO\naverage\tT-0\nuser\tO\n,\tO\nthat\tO\nmakes\tO\nit\tO\nrun\tO\nway\tO\nto\tO\nslow\tO\n.\tO\n\nIt\tO\nis\tO\nloaded\tO\nwith\tO\nprograms\tT-0\nthat\tO\nis\tO\nof\tO\nno\tO\ngood\tO\nfor\tO\nthe\tO\naverage\tO\nuser\tO\n,\tO\nthat\tO\nmakes\tO\nit\tO\nrun\tB-aspectTerm\nway\tT-1\nto\tT-1\nslow\tT-1\n.\tO\n\nI\tO\nfeel\tO\nthat\tO\nit\tO\nwas\tO\npoorly\tT-0\nput\tO\ntogether\tO\n,\tO\nbecause\tO\nonce\tO\nin\tO\na\tO\nwhile\tO\ndifferent\tO\nplastic\tB-aspectTerm\nÂ\tI-aspectTerm\npieces\tI-aspectTerm\nÂ\tO\nwould\tO\ncome\tO\noff\tT-1\nof\tO\nit\tO\n.\tT-1\n\nFinally\tO\n,\tO\nI\tO\nshould\tO\nnote\tO\nthat\tO\nI\tO\ntook\tT-0\nthe\tO\n2\tB-aspectTerm\nGB\tI-aspectTerm\nRAM\tI-aspectTerm\nstick\tI-aspectTerm\nfrom\tT-1\nmy\tO\nold\tO\nEeePC\tO\nand\tO\ninstalled\tT-2\nit\tO\nbefore\tO\nI\tO\neven\tO\npowered\tO\non\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\n.\tO\n\nWindows\tB-aspectTerm\nis\tO\nalso\tO\nrather\tO\nunsteady\tT-0\non\tO\nits\tO\nfeet\tO\nand\tO\nis\tO\nsusceptible\tT-1\nto\tO\nmany\tO\nbugs\tO\n.\tO\n\nAfter\tO\nsending\tO\nout\tO\ndocuments\tO\nvia\tO\nemail\tO\nand\tO\nhaving\tO\nrecipients\tO\ntell\tO\nme\tO\nthey\tO\ncould\tO\nnot\tO\nopen\tO\nthe\tO\ndocuments\tO\nor\tO\nthey\tO\ncame\tO\nthrough\tO\nas\tO\ngibberish\tO\n,\tO\nI\tO\nbroke\tO\ndown\tO\nand\tO\nspent\tT-0\nanother\tO\n$\tO\n100\tO\nto\tO\nget\tO\nMicrosoft\tB-aspectTerm\nWord\tI-aspectTerm\nfor\tI-aspectTerm\nMac\tI-aspectTerm\n.\tO\n\n"
  },
  {
    "path": "dataset/Laptop-reviews/trigger_turk.txt",
    "content": "I\tO\ncharge\tT-1\nit\tT-1\nat\tO\nnight\tO\nand\tO\nskip\tT-0\ntaking\tT-0\nthe\tT-0\ncord\tB-aspectTerm\nwith\tO\nme\tO\nbecause\tO\nof\tO\nthe\tO\ngood\tO\nbattery\tO\nlife\tO\n.\tO\n\nI\tO\ncharge\tT-0\nit\tO\nat\tO\nnight\tO\nand\tO\nskip\tO\ntaking\tO\nthe\tO\ncord\tT-1\nwith\tO\nme\tO\nbecause\tT-2\nof\tO\nthe\tO\ngood\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tO\n\nThe\tO\ntech\tB-aspectTerm\nguy\tI-aspectTerm\nthen\tO\nsaid\tO\nthe\tO\nservice\tT-1\ncenter\tT-1\ndoes\tO\nnot\tO\ndo\tO\n1-to-1\tO\nexchange\tO\nand\tO\nI\tO\nhave\tO\nto\tO\ndirect\tO\nmy\tO\nconcern\tO\nto\tO\nthe\tO\n\"\tO\nsales\tT-0\n\"\tO\nteam\tO\n,\tO\nwhich\tO\nis\tO\nthe\tO\nretail\tT-2\nshop\tT-2\nwhich\tO\nI\tO\nbought\tO\nmy\tO\nnetbook\tT-3\nfrom\tO\n.\tO\n\nThe\tO\ntech\tT-0\nguy\tT-0\nthen\tO\nsaid\tO\nthe\tO\nservice\tB-aspectTerm\ncenter\tI-aspectTerm\ndoes\tO\nnot\tO\ndo\tO\n1-to-1\tO\nexchange\tO\nand\tO\nI\tO\nhave\tO\nto\tO\ndirect\tO\nmy\tO\nconcern\tO\nto\tO\nthe\tO\n\"\tO\nsales\tO\n\"\tO\nteam\tO\n,\tO\nwhich\tO\nis\tO\nthe\tO\nretail\tO\nshop\tO\nwhich\tO\nI\tO\nbought\tO\nmy\tO\nnetbook\tO\nfrom\tO\n.\tO\n\nThe\tO\ntech\tT-0\nguy\tT-0\nthen\tO\nsaid\tO\nthe\tO\nservice\tT-1\ncenter\tT-1\ndoes\tO\nnot\tO\ndo\tO\n1-to-1\tO\nexchange\tO\nand\tO\nI\tO\nhave\tO\nto\tO\ndirect\tO\nmy\tO\nconcern\tO\nto\tO\nthe\tO\n\"\tB-aspectTerm\nsales\tI-aspectTerm\n\"\tI-aspectTerm\nteam\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\nthe\tO\nretail\tT-2\nshop\tT-2\nwhich\tO\nI\tO\nbought\tO\nmy\tO\nnetbook\tO\nfrom\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tB-aspectTerm\n,\tO\nhas\tO\na\tO\nkiller\tO\nGUI\tT-0\n,\tO\nis\tO\nextremely\tO\nstable\tT-1\n,\tO\nis\tO\nhighly\tO\nexpandable\tO\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tO\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tO\n,\tO\nhas\tT-0\na\tT-0\nkiller\tT-0\nGUI\tB-aspectTerm\n,\tO\nis\tO\nextremely\tO\nstable\tT-1\n,\tO\nis\tO\nhighly\tO\nexpandable\tO\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tO\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tT-0\n,\tO\nhas\tO\na\tO\nkiller\tO\nGUI\tT-1\n,\tO\nis\tO\nextremely\tT-3\nstable\tO\n,\tO\nis\tO\nhighly\tO\nexpandable\tT-2\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tB-aspectTerm\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nit\tO\nis\tO\nof\tO\nhigh\tO\nquality\tO\n,\tO\nhas\tO\na\tO\nkiller\tO\nGUI\tT-0\n,\tO\nis\tO\nextremely\tO\nstable\tO\n,\tO\nis\tO\nhighly\tO\nexpandable\tT-1\n,\tO\nis\tO\nbundled\tO\nwith\tO\nlots\tO\nof\tO\nvery\tO\ngood\tO\napplications\tO\n,\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tO\nand\tO\nis\tO\nabsolutely\tO\ngorgeous\tO\n.\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tT-0\nof\tT-0\nthe\tT-0\nfeatures\tB-aspectTerm\nthat\tT-1\nit\tT-1\noffers\tT-1\n,\tO\nlike\tO\n,\tO\niChat\tT-2\n,\tO\nPhotobooth\tT-3\n,\tO\ngarage\tO\nband\tO\nand\tO\nmore\tO\n!\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nfeatures\tO\nthat\tO\nit\tO\noffers\tO\n,\tO\nlike\tO\n,\tO\niChat\tB-aspectTerm\n,\tO\nPhotobooth\tT-0\n,\tO\ngarage\tT-1\nband\tT-2\nand\tO\nmore\tO\n!\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nfeatures\tT-0\nthat\tO\nit\tO\noffers\tO\n,\tO\nlike\tO\n,\tO\niChat\tT-1\n,\tO\nPhotobooth\tB-aspectTerm\n,\tO\ngarage\tT-2\nband\tT-2\nand\tO\nmore\tO\n!\tO\n\nI\tO\neven\tO\ngot\tO\nmy\tO\nteenage\tO\nson\tO\none\tO\n,\tO\nbecause\tO\nof\tO\nthe\tO\nfeatures\tO\nthat\tO\nit\tT-0\noffers\tO\n,\tO\nlike\tO\n,\tO\niChat\tO\n,\tO\nPhotobooth\tO\n,\tO\ngarage\tB-aspectTerm\nband\tI-aspectTerm\nand\tO\nmore\tO\n!\tO\n\nGreat\tO\nlaptop\tT-1\nthat\tO\noffers\tT-0\nmany\tT-0\ngreat\tT-0\nfeatures\tB-aspectTerm\n!\tO\n\nÂ\tO\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tB-aspectTerm\n,\tO\nscreen\tO\nall\tO\ndark\tO\n,\tO\npower\tO\nlight\tO\nsteady\tO\n,\tO\nhard\tO\ndrive\tO\nlight\tO\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tT-1\n\nÂ\tO\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tO\n,\tO\nscreen\tB-aspectTerm\nall\tO\ndark\tO\n,\tO\npower\tO\nlight\tO\nsteady\tO\n,\tO\nhard\tO\ndrive\tO\nlight\tO\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tT-1\n\nÂ\tO\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tO\n,\tO\nscreen\tO\nall\tO\ndark\tO\n,\tO\npower\tB-aspectTerm\nlight\tI-aspectTerm\nsteady\tO\n,\tO\nhard\tO\ndrive\tO\nlight\tO\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tT-1\n\nÂ\tO\nOne\tO\nnight\tO\nI\tO\nturned\tO\nthe\tO\nfreaking\tO\nthing\tO\noff\tO\nafter\tO\nusing\tO\nit\tO\n,\tO\nthe\tO\nnext\tO\nday\tO\nI\tO\nturn\tO\nit\tO\non\tO\n,\tO\nno\tO\nGUI\tO\n,\tO\nscreen\tO\nall\tO\ndark\tO\n,\tO\npower\tO\nlight\tO\nsteady\tO\n,\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nlight\tI-aspectTerm\nsteady\tO\nand\tO\nnot\tO\nflashing\tO\nas\tO\nit\tO\nusually\tO\ndoes\tO\n.\tT-1\n\nI\tO\ntook\tO\nit\tO\nback\tO\nfor\tO\nan\tO\nAsus\tT-0\nand\tO\nsame\tO\nthing-\tO\nblue\tO\nscreen\tO\nwhich\tO\nrequired\tO\nme\tO\nto\tO\nremove\tT-1\nthe\tO\nbattery\tB-aspectTerm\nto\tO\nreset\tO\n.\tO\n\nIn\tO\nthe\tO\nshop\tO\n,\tO\nthese\tO\nMacBooks\tT-1\nare\tO\nencased\tO\nin\tO\na\tO\nsoft\tT-0\nrubber\tB-aspectTerm\nenclosure\tI-aspectTerm\n-\tO\nso\tO\nyou\tO\nwill\tO\nnever\tO\nknow\tO\nabout\tO\nthe\tO\nrazor\tT-2\nedge\tT-2\nuntil\tO\nyou\tO\nbuy\tO\nit\tO\n,\tO\nget\tO\nit\tO\nhome\tO\n,\tO\nbreak\tO\nthe\tO\nseal\tO\nand\tO\nuse\tO\nit\tO\n(\tO\nvery\tO\nclever\tO\ncon\tO\n)\tO\n.\tO\n\nIn\tO\nthe\tO\nshop\tO\n,\tO\nthese\tO\nMacBooks\tT-1\nare\tO\nencased\tT-2\nin\tO\na\tO\nsoft\tO\nrubber\tT-3\nenclosure\tT-3\n-\tO\nso\tO\nyou\tO\nwill\tO\nnever\tO\nknow\tO\nabout\tO\nthe\tO\nrazor\tT-0\nedge\tB-aspectTerm\nuntil\tO\nyou\tO\nbuy\tO\nit\tO\n,\tO\nget\tO\nit\tO\nhome\tO\n,\tO\nbreak\tO\nthe\tO\nseal\tO\nand\tO\nuse\tO\nit\tO\n(\tO\nvery\tO\nclever\tO\ncon\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\ngestures\tI-aspectTerm\nand\tO\nlarge\tO\ntracking\tT-0\narea\tO\nmake\tO\nhaving\tO\nan\tO\nexternal\tO\nmouse\tO\nunnecessary\tO\n(\tO\nunless\tO\nyou\tO\n're\tO\ngaming\tO\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tT-1\n-\tT-1\ntouch\tT-1\ngestures\tO\nand\tO\nlarge\tO\ntracking\tB-aspectTerm\narea\tI-aspectTerm\nmake\tO\nhaving\tO\nan\tO\nexternal\tT-0\nmouse\tO\nunnecessary\tO\n(\tO\nunless\tO\nyou\tO\n're\tO\ngaming\tT-2\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tT-0\n-\tT-0\ntouch\tT-0\ngestures\tO\nand\tO\nlarge\tO\ntracking\tT-1\narea\tT-1\nmake\tO\nhaving\tO\nan\tO\nexternal\tB-aspectTerm\nmouse\tI-aspectTerm\nunnecessary\tT-3\n(\tO\nunless\tO\nyou\tO\n're\tO\ngaming\tT-2\n)\tO\n.\tO\n\nHowever\tO\n,\tO\nthe\tO\nmulti\tO\n-\tO\ntouch\tO\ngestures\tO\nand\tO\nlarge\tO\ntracking\tO\narea\tO\nmake\tO\nhaving\tO\nan\tO\nexternal\tT-1\nmouse\tO\nunnecessary\tO\n(\tO\nunless\tT-0\nyou\tT-0\n're\tT-0\ngaming\tB-aspectTerm\n)\tO\n.\tO\n\nI\tO\nlove\tO\nthe\tO\nway\tO\nthe\tO\nentire\tO\nsuite\tB-aspectTerm\nof\tI-aspectTerm\nsoftware\tI-aspectTerm\nworks\tO\ntogether\tT-0\n.\tO\n\nThe\tO\nspeed\tB-aspectTerm\nis\tO\nincredible\tT-1\nand\tO\nI\tO\nam\tO\nmore\tO\nthan\tO\nsatisfied\tT-0\n.\tO\n\nThis\tO\nlaptop\tT-1\nmeets\tO\nevery\tO\nexpectation\tO\nand\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nis\tT-0\ngreat\tT-0\n!\tO\n\nI\tO\ncan\tO\nbarely\tO\nuse\tT-1\nany\tO\nusb\tB-aspectTerm\ndevices\tI-aspectTerm\nbecause\tO\nthey\tO\nwill\tO\nnot\tO\nstay\tO\nconnected\tT-0\nproperly\tO\n.\tO\n\nWhen\tO\nI\tO\nfinally\tO\nhad\tO\neverything\tO\nrunning\tT-0\nwith\tO\nall\tO\nmy\tO\nsoftware\tB-aspectTerm\ninstalled\tO\nI\tO\nplugged\tT-1\nin\tT-1\nmy\tO\ndroid\tT-2\nto\tO\nrecharge\tO\nand\tO\nthe\tO\nsystem\tT-3\ncrashed\tO\n.\tO\n\nWhen\tO\nI\tO\nfinally\tO\nhad\tO\neverything\tO\nrunning\tO\nwith\tO\nall\tO\nmy\tO\nsoftware\tO\ninstalled\tT-0\nI\tO\nplugged\tT-1\nin\tO\nmy\tO\ndroid\tT-3\nto\tT-2\nrecharge\tT-4\nand\tO\nthe\tO\nsystem\tB-aspectTerm\ncrashed\tO\n.\tO\n\nOne\tO\nsuggestion\tO\nI\tO\ndo\tO\nhave\tO\n,\tO\nis\tO\nto\tO\nnot\tT-0\nbother\tT-0\ngetting\tT-0\nMicrosoft\tB-aspectTerm\noffice\tI-aspectTerm\nfor\tI-aspectTerm\nthe\tI-aspectTerm\nmac\tI-aspectTerm\nexpecting\tO\nit\tO\nwill\tO\nwork\tT-1\njust\tO\nlike\tO\nyou\tO\nknew\tO\nit\tO\nto\tO\non\tO\na\tO\nPC\tO\n.\tO\n\nPairing\tT-0\nit\tO\nwith\tO\nan\tO\niPhone\tT-1\nis\tO\na\tO\npure\tO\npleasure\tO\n-\tO\ntalk\tO\nabout\tO\npainless\tO\nsyncing\tB-aspectTerm\n-\tO\nused\tO\nto\tO\ntake\tO\nme\tO\nforever\tO\n-\tO\nnow\tO\nit\tO\n's\tO\na\tO\nsnap\tT-2\n.\tO\n\nI\tO\nalso\tO\ngot\tO\nthe\tO\nadded\tO\nbonus\tT-1\nof\tO\na\tO\n30\tB-aspectTerm\n\"\tI-aspectTerm\nHD\tI-aspectTerm\nMonitor\tI-aspectTerm\n,\tO\nwhich\tO\nreally\tT-0\nhelps\tT-0\nto\tT-0\nextend\tO\nmy\tO\nscreen\tO\nand\tO\nkeep\tO\nmy\tO\neyes\tO\nfresh\tO\n!\tO\n\nI\tO\nalso\tO\ngot\tO\nthe\tO\nadded\tO\nbonus\tO\nof\tO\na\tO\n30\tO\n\"\tO\nHD\tT-1\nMonitor\tT-1\n,\tO\nwhich\tO\nreally\tO\nhelps\tO\nto\tO\nextend\tT-0\nmy\tO\nscreen\tB-aspectTerm\nand\tO\nkeep\tO\nmy\tO\neyes\tO\nfresh\tO\n!\tO\n\nThe\tO\nmachine\tT-0\nis\tO\nslow\tO\nto\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nand\tO\noccasionally\tO\ncrashes\tO\ncompletely\tO\n.\tO\n\nAfter\tO\npaying\tT-1\nseveral\tO\nhundred\tO\ndollars\tO\nfor\tO\nthis\tO\nservice\tB-aspectTerm\n,\tO\nit\tO\nis\tO\nfrustrating\tO\nthat\tO\nyou\tO\ncan\tO\nnot\tO\nget\tT-0\nhelp\tT-0\nafter\tO\nhours\tO\n.\tO\n\nI\tO\ndid\tO\nhave\tO\nto\tO\nreplace\tT-1\nthe\tO\nbattery\tB-aspectTerm\nonce\tO\n,\tO\nbut\tO\nthat\tO\nwas\tO\nonly\tO\na\tO\ncouple\tO\nmonths\tO\nago\tO\nand\tO\nit\tT-0\n's\tT-0\nbeen\tT-0\nworking\tT-0\nperfect\tT-0\never\tT-0\nsince\tT-0\n.\tO\n\nI\tO\nlove\tO\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\nand\tO\nthe\tO\npreloaded\tT-0\nsoftware\tT-1\n.\tT-1\n\nI\tO\nlove\tO\nthe\tO\noperating\tO\nsystem\tO\nand\tO\nthe\tO\npreloaded\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tT-0\n\nThe\tO\nbest\tO\nthing\tO\nabout\tO\nthis\tO\nlaptop\tT-0\nis\tO\nthe\tO\nprice\tB-aspectTerm\nalong\tO\nwith\tO\nsome\tO\nof\tO\nthe\tO\nnewer\tO\nfeatures\tO\n.\tT-1\n\nThe\tO\nbest\tO\nthing\tO\nabout\tO\nthis\tO\nlaptop\tO\nis\tO\nthe\tO\nprice\tO\nalong\tO\nwith\tO\nsome\tO\nof\tO\nthe\tO\nnewer\tT-0\nfeatures\tB-aspectTerm\n.\tO\n\nAfter\tO\nnumerous\tO\nattempts\tO\nof\tO\ntrying\tT-1\n(\tO\nincluding\tO\nsetting\tT-0\nthe\tO\nclock\tB-aspectTerm\nin\tI-aspectTerm\nBIOS\tI-aspectTerm\nsetup\tI-aspectTerm\ndirectly\tO\n)\tO\n,\tO\nI\tO\ngave\tO\nup(I\tO\nam\tO\na\tO\ntechie\tO\n)\tO\n.\tO\n\nYOU\tO\nWILL\tO\nNOT\tO\nBE\tO\nABLE\tO\nTO\tO\nTALK\tO\nTO\tO\nAN\tO\nAMERICAN\tT-0\nWARRANTY\tB-aspectTerm\nSERVICE\tI-aspectTerm\nIS\tO\nOUT\tO\nOF\tO\nCOUNTRY\tO\n.\tO\n\nbut\tO\nnow\tO\ni\tO\nhave\tO\nrealized\tO\nits\tO\na\tO\nproblem\tT-0\nwith\tT-0\nthis\tO\nbrand\tB-aspectTerm\n.\tO\n\nI\tO\nsent\tO\nit\tO\nback\tO\nto\tO\nToshiba\tT-0\ntwice\tO\nthey\tO\ncovered\tT-1\nit\tO\nunder\tT-3\nthe\tO\nO\tT-2\nwarranty\tB-aspectTerm\n.\tO\n\nAlso\tO\nkinda\tT-2\nloud\tT-1\nwhen\tO\nthe\tO\nfan\tB-aspectTerm\nwas\tT-0\nrunning\tT-0\n.\tO\n\nIn\tO\ndesparation\tO\n,\tO\nI\tO\ncalled\tO\ntheir\tO\nCustomer\tB-aspectTerm\nService\tI-aspectTerm\nnumber\tI-aspectTerm\nand\tO\nwas\tO\ntold\tO\nthat\tO\nmy\tO\nwarranty\tT-1\nhad\tO\nexpired\tT-0\n(\tO\n2\tO\ndays\tO\nold\tO\n)\tO\nand\tO\nthat\tO\nthe\tO\npriviledge\tO\nof\tO\ntalking\tO\nto\tO\na\tO\ntechnician\tO\nwould\tO\ncost\tO\nme\tO\n(\tO\n\"\tO\nhave\tO\nyour\tO\ncredit\tO\ncard\tO\nready\tO\n\"\tO\n)\tO\n.\tO\n\nIn\tO\ndesparation\tO\n,\tO\nI\tO\ncalled\tO\ntheir\tO\nCustomer\tT-1\nService\tT-1\nnumber\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nmy\tO\nwarranty\tB-aspectTerm\nhad\tT-2\nexpired\tT-2\n(\tO\n2\tO\ndays\tO\nold\tO\n)\tO\nand\tO\nthat\tO\nthe\tO\npriviledge\tO\nof\tO\ntalking\tO\nto\tO\na\tO\ntechnician\tT-0\nwould\tO\ncost\tO\nme\tO\n(\tO\n\"\tO\nhave\tO\nyour\tO\ncredit\tO\ncard\tO\nready\tO\n\"\tO\n)\tO\n.\tO\n\nIn\tO\ndesparation\tO\n,\tO\nI\tO\ncalled\tT-0\ntheir\tO\nCustomer\tO\nService\tO\nnumber\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nmy\tO\nwarranty\tT-2\nhad\tO\nexpired\tO\n(\tO\n2\tO\ndays\tO\nold\tO\n)\tO\nand\tO\nthat\tO\nthe\tO\npriviledge\tT-3\nof\tT-3\ntalking\tB-aspectTerm\nto\tI-aspectTerm\na\tI-aspectTerm\ntechnician\tI-aspectTerm\nwould\tT-1\ncost\tT-1\nme\tT-1\n(\tO\n\"\tO\nhave\tO\nyour\tO\ncredit\tO\ncard\tO\nready\tO\n\"\tO\n)\tO\n.\tO\n\nThere\tO\nalso\tO\nseemed\tO\nto\tO\nbe\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\nhard\tB-aspectTerm\ndisc\tI-aspectTerm\nas\tO\ncertain\tO\ntimes\tO\nwindows\tT-0\nloads\tO\nbut\tO\nclaims\tO\nto\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\nfind\tO\nany\tO\ndrivers\tT-1\nor\tO\nfiles\tO\n.\tO\n\nThere\tO\nalso\tO\nseemed\tO\nto\tO\nbe\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\nhard\tO\ndisc\tO\nas\tO\ncertain\tO\ntimes\tT-1\nwindows\tB-aspectTerm\nloads\tT-0\nbut\tO\nclaims\tO\nto\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\nfind\tO\nany\tO\ndrivers\tO\nor\tO\nfiles\tO\n.\tO\n\nThere\tO\nalso\tO\nseemed\tO\nto\tO\nbe\tO\na\tO\nproblem\tO\nwith\tO\nthe\tO\nhard\tO\ndisc\tT-2\nas\tO\ncertain\tO\ntimes\tO\nwindows\tT-0\nloads\tO\nbut\tO\nclaims\tO\nto\tO\nnot\tO\nbe\tO\nable\tO\nto\tO\nfind\tT-1\nany\tO\ndrivers\tB-aspectTerm\nor\tO\nfiles\tT-3\n.\tO\n\nDrivers\tB-aspectTerm\nupdated\tT-0\nok\tO\nbut\tO\nthe\tO\nBIOS\tT-1\nupdate\tO\nfroze\tO\nthe\tO\nsystem\tO\nup\tO\nand\tO\nthe\tO\ncomputer\tO\nshut\tO\ndown\tO\n.\tO\n\nDrivers\tO\nupdated\tT-1\nok\tO\nbut\tO\nthe\tO\nBIOS\tB-aspectTerm\nupdate\tI-aspectTerm\nfroze\tT-2\nthe\tT-2\nsystem\tT-2\nup\tT-2\nand\tO\nthe\tO\ncomputer\tT-0\nshut\tT-3\ndown\tT-3\n.\tO\n\nDrivers\tO\nupdated\tO\nok\tO\nbut\tO\nthe\tO\nBIOS\tO\nupdate\tO\nfroze\tT-0\nthe\tO\nsystem\tB-aspectTerm\nup\tT-1\nand\tO\nthe\tO\ncomputer\tO\nshut\tO\ndown\tO\n.\tO\n\nSpent\tT-0\n2\tO\nhours\tO\non\tT-2\nphone\tT-2\nwith\tT-2\nHP\tB-aspectTerm\nTechnical\tI-aspectTerm\nSupport\tI-aspectTerm\n.\tT-1\n\nThe\tO\nkeyboard\tB-aspectTerm\nis\tO\ntoo\tO\nslick\tT-0\n.\tO\n\nNightly\tO\nmy\tO\ncomputer\tO\ndefrags\tT-1\nitself\tO\nand\tO\nruns\tO\na\tO\nvirus\tB-aspectTerm\nscan\tI-aspectTerm\n.\tT-0\n\nIt\tO\n's\tO\nlike\tO\n9\tB-aspectTerm\npunds\tI-aspectTerm\n,\tO\nbut\tO\nif\tO\nyou\tO\ncan\tO\nlook\tT-0\npast\tT-2\nit\tT-1\n,\tO\nit\tO\n's\tO\nGREAT\tO\n!\tO\n\nIt\tO\n's\tO\njust\tO\nas\tO\nfast\tT-1\nwith\tO\none\tO\nprogram\tB-aspectTerm\nopen\tT-0\nas\tO\nit\tO\nis\tO\nwith\tO\nsixteen\tO\nopen\tO\n.\tO\n\nStill\tO\nunder\tO\nwarrenty\tB-aspectTerm\nso\tO\ncalled\tO\nToshiba\tT-1\n,\tO\nno\tO\nhelp\tT-0\nat\tO\nall\tO\n.\tO\n\nI\tO\nwas\tO\nhappy\tO\nwith\tO\nMy\tO\npurchase\tO\nof\tO\na\tO\nToshiba\tO\nSatellite\tO\nL305D\tO\n-\tO\nS5934\tO\nlaptop\tO\nuntil\tO\nit\tO\ncame\tO\ntime\tO\nto\tO\nhave\tO\nit\tO\nrepaired\tT-0\nunder\tO\nthe\tO\nToshiba\tB-aspectTerm\nWarranty\tI-aspectTerm\n.\tO\n\nAmazing\tT-0\nQuality\tB-aspectTerm\n!\tO\n\nThe\tO\nfact\tO\nthat\tO\nyou\tO\ncan\tO\nspend\tO\nover\tO\n$\tO\n100\tO\non\tO\njust\tO\na\tO\nwebcam\tB-aspectTerm\nunderscores\tT-0\nthe\tO\nvalue\tO\nof\tO\nthis\tO\nmachine\tO\n.\tO\n\nThe\tO\nfact\tO\nthat\tO\nyou\tO\ncan\tO\nspend\tO\nover\tO\n$\tO\n100\tO\non\tO\njust\tT-0\na\tO\nwebcam\tT-1\nunderscores\tO\nthe\tO\nvalue\tB-aspectTerm\nof\tO\nthis\tO\nmachine\tT-2\n.\tO\n\nI\tO\nmainly\tO\nuse\tT-1\nit\tT-1\nfor\tT-1\nemail\tO\n,\tO\ninternet\tB-aspectTerm\n,\tO\nand\tO\nmanaging\tT-0\npersonal\tO\nfiles\tO\n(\tO\npics\tO\n,\tO\nvids\tO\n,\tO\netc\tO\n.\tO\n)\tO\n.\tO\n\nI\tO\nmainly\tO\nuse\tO\nit\tO\nfor\tO\nemail\tO\n,\tO\ninternet\tO\n,\tO\nand\tO\nmanaging\tB-aspectTerm\npersonal\tI-aspectTerm\nfiles\tI-aspectTerm\n(\tO\npics\tT-0\n,\tT-0\nvids\tT-0\n,\tT-0\netc\tT-0\n.\tO\n)\tO\n.\tO\n\nA\tO\nmonth\tT-0\nor\tO\nso\tO\nago\tO\n,\tO\nthe\tO\nfreaking\tO\nmotherboard\tB-aspectTerm\njust\tO\ndied\tT-1\n.\tO\n\nThe\tO\nsystem\tB-aspectTerm\nit\tO\ncomes\tO\nwith\tO\ndoes\tO\nnot\tO\nwork\tO\nproperly\tT-0\n,\tO\nso\tO\nwhen\tO\ntrying\tO\nto\tO\nfix\tO\nthe\tO\nproblems\tO\nwith\tO\nit\tO\nit\tO\nstarted\tO\nnot\tO\nworking\tO\nat\tO\nall\tO\n.\tO\n\nThen\tO\nafter\tO\n4\tO\nor\tO\nso\tO\nmonths\tO\nthe\tO\ncharger\tB-aspectTerm\nstopped\tO\nworking\tT-0\nso\tO\nI\tO\nwas\tO\nforced\tO\nto\tO\ngo\tO\nout\tO\nand\tO\nbuy\tO\nnew\tO\nhardware\tT-1\njust\tO\nto\tO\nkeep\tO\nthis\tO\ncomputer\tT-2\nrunning\tO\n.\tO\n\nThen\tO\nafter\tO\n4\tO\nor\tO\nso\tO\nmonths\tO\nthe\tO\ncharger\tT-0\nstopped\tO\nworking\tO\nso\tO\nI\tO\nwas\tO\nforced\tO\nto\tO\ngo\tO\nout\tO\nand\tO\nbuy\tO\nnew\tO\nhardware\tB-aspectTerm\njust\tO\nto\tO\nkeep\tT-1\nthis\tT-1\ncomputer\tT-1\nrunning\tT-1\n.\tO\n\nIf\tO\na\tO\nwebsite\tO\never\tO\nfreezes\tT-1\n(\tO\nwhich\tO\nis\tO\nrare\tO\n)\tO\n,\tO\nits\tO\nreally\tO\neasy\tT-0\nto\tT-0\nforce\tB-aspectTerm\nquit\tI-aspectTerm\n.\tO\n\nIt\tT-1\nrarely\tT-1\nworks\tB-aspectTerm\nand\tO\nwhen\tO\nit\tO\ndoes\tO\nit\tO\n's\tO\nincredibly\tT-0\nslow\tO\n.\tO\n\nI\tO\nalso\tO\nenjoy\tO\nthe\tO\nfact\tO\nthat\tO\nmy\tO\nMacBook\tT-0\nPro\tO\nlaptop\tO\nallows\tO\nme\tO\nto\tO\nrun\tT-1\nWindows\tB-aspectTerm\n7\tI-aspectTerm\non\tO\nit\tO\nby\tO\nusing\tO\nthe\tO\nVMWare\tO\nprogram\tO\n.\tO\n\nI\tO\nalso\tO\nenjoy\tO\nthe\tO\nfact\tO\nthat\tO\nmy\tO\nMacBook\tT-2\nPro\tO\nlaptop\tO\nallows\tO\nme\tO\nto\tO\nrun\tO\nWindows\tT-0\n7\tT-0\non\tO\nit\tO\nby\tO\nusing\tT-1\nthe\tT-1\nVMWare\tB-aspectTerm\nprogram\tI-aspectTerm\n.\tO\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tT-1\nto\tT-1\nnavigate\tB-aspectTerm\nthrough\tT-0\nthe\tO\noperating\tO\nsystem\tO\n,\tO\nto\tO\nfind\tO\nfiles\tO\n,\tO\nand\tO\nit\tO\nruns\tO\na\tO\nlot\tO\nfaster\tO\n!\tO\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tO\nto\tO\nnavigate\tT-1\nthrough\tT-1\nthe\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n,\tO\nto\tO\nfind\tO\nfiles\tO\n,\tO\nand\tO\nit\tO\nruns\tO\na\tO\nlot\tO\nfaster\tO\n!\tT-0\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tO\nto\tO\nnavigate\tT-0\nthrough\tO\nthe\tO\noperating\tT-1\nsystem\tT-1\n,\tO\nto\tO\nfind\tB-aspectTerm\nfiles\tI-aspectTerm\n,\tO\nand\tO\nit\tO\nruns\tO\na\tO\nlot\tO\nfaster\tO\n!\tO\n\nIt\tO\n's\tO\nso\tO\nmuch\tO\neasier\tT-1\nto\tO\nnavigate\tT-2\nthrough\tO\nthe\tO\noperating\tT-3\nsystem\tO\n,\tO\nto\tO\nfind\tO\nfiles\tO\n,\tO\nand\tO\nit\tO\nruns\tB-aspectTerm\na\tT-0\nlot\tT-0\nfaster\tT-0\n!\tT-0\n\nPurchased\tO\na\tO\nToshiba\tT-0\nLap\tT-1\ntop\tT-1\nit\tO\nworked\tO\ngood\tO\nuntil\tO\njust\tO\nafter\tT-2\nthe\tO\nwarrenty\tB-aspectTerm\nwent\tO\nout\tO\n.\tO\n\nI\tO\nwanted\tO\nto\tO\npurchase\tO\nthe\tO\nextended\tB-aspectTerm\nwarranty\tI-aspectTerm\nand\tO\nthey\tO\nrefused\tT-1\n,\tO\nbecause\tO\nthey\tO\nknew\tO\nit\tO\nwas\tO\ntrouble\tT-0\n.\tO\n\nWe\tO\nupgraded\tO\nthe\tO\nmemory\tB-aspectTerm\nto\tO\nfour\tO\ngigabytes\tT-0\nin\tO\norder\tO\nto\tO\ntake\tO\nadvantage\tO\nof\tO\nthe\tO\nperformace\tO\nincrease\tO\nin\tO\nspeed\tO\n.\tT-1\n\nWe\tO\nupgraded\tT-0\nthe\tO\nmemory\tO\nto\tO\nfour\tO\ngigabytes\tT-1\nin\tO\norder\tO\nto\tO\ntake\tO\nadvantage\tO\nof\tO\nthe\tO\nperformace\tB-aspectTerm\nincrease\tO\nin\tO\nspeed\tO\n.\tO\n\nWe\tO\nupgraded\tT-0\nthe\tO\nmemory\tT-2\nto\tO\nfour\tO\ngigabytes\tT-1\nin\tO\norder\tO\nto\tO\ntake\tO\nadvantage\tO\nof\tO\nthe\tO\nperformace\tT-3\nincrease\tO\nin\tO\nspeed\tB-aspectTerm\n.\tO\n\nThe\tO\nreality\tO\nwas\tO\n,\tO\nit\tO\nheated\tT-1\nup\tT-1\nvery\tO\nquickly\tO\n,\tO\nand\tO\ntook\tO\nway\tO\ntoo\tO\nlong\tT-0\nto\tO\ndo\tO\nsimple\tO\nthings\tO\n,\tO\nlike\tO\nopening\tB-aspectTerm\nmy\tI-aspectTerm\nDocuments\tI-aspectTerm\nfolder\tI-aspectTerm\n.\tO\n\nI\tO\nhad\tO\nalways\tO\nused\tO\nPCs\tO\nand\tO\nbeen\tO\nconstantly\tO\nfrustrated\tO\nby\tO\nthe\tO\ncrashing\tT-1\nand\tO\nthe\tO\npoorly\tT-2\ndesigned\tT-2\noperating\tB-aspectTerm\nsystems\tI-aspectTerm\nthat\tT-0\nwere\tT-0\nnever\tT-0\nvery\tT-0\nintuitive\tT-0\n.\tO\n\nThen\tO\n,\tO\nwithin\tO\n5\tO\nmonths\tO\n,\tO\nthe\tO\ncharger\tB-aspectTerm\ncrapped\tT-0\nout\tO\non\tO\nme\tO\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\nhave\tO\na\tO\niphone\tO\nor\tO\nipod\tO\ntouch\tO\nyou\tO\ncan\tO\nconnect\tO\nand\tO\ndownload\tT-0\nsongs\tO\nto\tO\nit\tO\nat\tO\nhigh\tT-1\nspeed\tB-aspectTerm\n.\tO\n\nI\tT-0\nlove\tT-0\nthe\tT-0\nglass\tB-aspectTerm\ntouchpad\tI-aspectTerm\n.\tO\n\nÂ\tT-0\nI\tO\ncontinued\tO\nto\tO\ntake\tO\nthe\tO\ncomputer\tO\nin\tO\nAGAIN\tO\nand\tO\nthey\tO\nreplaced\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nmother\tO\nboard\tO\nyet\tO\nagain\tO\n.\tT-0\n\nÂ\tT-0\nI\tO\ncontinued\tO\nto\tO\ntake\tO\nthe\tO\ncomputer\tO\nin\tO\nAGAIN\tO\nand\tO\nthey\tO\nreplaced\tO\nthe\tO\nhard\tO\ndrive\tO\nand\tO\nmother\tB-aspectTerm\nboard\tI-aspectTerm\nyet\tO\nagain\tO\n.\tT-0\n\nI\tT-0\nam\tT-0\nusing\tT-0\nthe\tT-0\nexternal\tB-aspectTerm\nspeaker-\tI-aspectTerm\nsound\tT-1\nis\tO\ngood\tO\n.\tO\n\nI\tO\nam\tO\nusing\tO\nthe\tO\nexternal\tT-0\nspeaker-\tT-1\nsound\tB-aspectTerm\nis\tO\ngood\tT-2\n.\tT-1\n\nstill\tO\ntesting\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nas\tO\ni\tO\nthought\tO\nit\tO\nwould\tO\nbe\tO\nbetter\tO\n,\tO\nbut\tO\nam\tO\nvery\tO\nhappy\tO\nwith\tO\nthe\tO\nupgrade\tT-0\n.\tO\n\nThen\tO\nHP\tO\nsends\tO\nit\tO\nback\tO\nto\tO\nme\tO\nwith\tO\nthe\tO\nhardware\tB-aspectTerm\nscrewed\tT-0\nup\tT-0\n,\tO\nnot\tO\nable\tO\nto\tO\nconnect\tT-1\n.\tO\n\nOh\tO\nyeah\tO\n,\tO\ndo\tO\nn't\tO\nforget\tO\nthe\tO\nexpensive\tO\nshipping\tB-aspectTerm\nto\tO\nand\tO\nfrom\tO\nHP\tT-0\n.\tO\n\nEverything\tO\nis\tO\nso\tO\neasy\tT-1\nto\tO\nuse\tB-aspectTerm\n,\tO\nMac\tO\nsoftware\tO\nis\tO\njust\tO\nso\tO\nmuch\tO\nsimpler\tT-0\nthan\tO\nMicrosoft\tO\nsoftware\tO\n.\tO\n\nEverything\tO\nis\tO\nso\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nMac\tB-aspectTerm\nsoftware\tI-aspectTerm\nis\tT-1\njust\tT-1\nso\tT-1\nmuch\tT-1\nsimpler\tT-1\nthan\tT-1\nMicrosoft\tT-1\nsoftware\tT-1\n.\tT-0\n\nEverything\tO\nis\tO\nso\tO\neasy\tO\nto\tO\nuse\tT-0\n,\tO\nMac\tT-1\nsoftware\tT-2\nis\tO\njust\tO\nso\tO\nmuch\tO\nsimpler\tT-3\nthan\tO\nMicrosoft\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\ndo\tO\na\tO\nlot\tO\nof\tO\nwriting\tO\n,\tO\nediting\tB-aspectTerm\nis\tO\na\tO\nproblem\tT-0\nsince\tO\nthere\tO\nis\tO\nno\tO\nO\tO\nforward\tO\ndelete\tO\nI-aspectTerm\tO\nkey\tO\n.\tO\n\nAnd\tO\nif\tO\nyou\tO\ndo\tO\na\tO\nlot\tO\nof\tO\nwriting\tO\n,\tO\nediting\tT-1\nis\tO\na\tO\nproblem\tO\nsince\tO\nthere\tO\nis\tO\nno\tO\nO\tT-0\nforward\tT-0\ndelete\tB-aspectTerm\nI-aspectTerm\tI-aspectTerm\nkey\tI-aspectTerm\n.\tO\n\nIts\tT-0\nease\tT-0\nof\tT-0\nuse\tB-aspectTerm\nand\tO\nthe\tO\ntop\tT-1\nservice\tO\nfrom\tO\nApple-\tO\nbe\tO\nit\tO\ntheir\tO\nphone\tO\nassistance\tO\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tO\nbar-\tO\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tO\n\nIts\tO\nease\tO\nof\tO\nuse\tO\nand\tO\nthe\tO\ntop\tO\nservice\tB-aspectTerm\nfrom\tO\nApple-\tT-0\nbe\tO\nit\tO\ntheir\tO\nphone\tO\nassistance\tO\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tO\nbar-\tO\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tT-0\n\nIts\tO\nease\tO\nof\tO\nuse\tO\nand\tO\nthe\tO\ntop\tT-1\nservice\tT-1\nfrom\tO\nApple-\tO\nbe\tO\nit\tO\ntheir\tO\nphone\tB-aspectTerm\nassistance\tI-aspectTerm\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tO\nbar-\tO\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tT-0\n\nIts\tO\nease\tO\nof\tO\nuse\tO\nand\tO\nthe\tO\ntop\tO\nservice\tO\nfrom\tO\nApple-\tT-0\nbe\tO\nit\tO\ntheir\tO\nphone\tT-1\nassistance\tO\nor\tO\nbellying\tO\nup\tO\nto\tO\nthe\tO\ngenius\tB-aspectTerm\nbar-\tI-aspectTerm\ncan\tO\nnot\tO\nbe\tO\nbeat\tO\n.\tT-0\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tT-0\nbrowsing\tT-0\nand\tT-0\nword\tT-0\nediting\tT-0\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tT-1\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tO\nand\tO\nmovie\tO\nplaying\tO\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tO\nlife\tO\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-1\nlife\tT-1\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\nand\tO\nword\tT-0\nediting\tT-0\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tO\nand\tO\nmovie\tO\nplaying\tO\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tO\nlife\tO\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-0\nlife\tO\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tO\nbrowsing\tO\nand\tO\nword\tB-aspectTerm\nediting\tI-aspectTerm\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tT-1\nand\tT-1\nmovie\tT-1\nplaying\tT-1\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tO\nlife\tO\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-3\nlife\tT-3\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tT-1\nbrowsing\tT-1\nand\tO\nword\tT-2\nediting\tT-2\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tO\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tB-aspectTerm\nand\tO\nmovie\tO\nplaying\tO\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tT-0\nlife\tT-0\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-1\nlife\tO\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tO\nbrowsing\tO\nand\tO\nword\tO\nediting\tO\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tT-2\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tT-3\nand\tO\nmovie\tB-aspectTerm\nplaying\tI-aspectTerm\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tT-0\nlife\tT-0\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nIt\tO\nhas\tO\na\tO\n10\tO\nhour\tO\nbattery\tT-2\nlife\tO\nwhen\tO\nyou\tO\n're\tO\ndoing\tO\nweb\tO\nbrowsing\tT-3\nand\tO\nword\tO\nediting\tO\n,\tO\nmaking\tO\nit\tO\nperfect\tO\nfor\tO\nthe\tO\nclassroom\tO\nor\tO\noffice\tT-0\n,\tO\nand\tO\nin\tO\nterms\tO\nof\tO\ngaming\tT-1\nand\tO\nmovie\tO\nplaying\tO\nit\tO\n'll\tO\nhave\tO\na\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nof\tO\njust\tO\nover\tO\n5\tO\nhours\tO\n.\tO\n\nAcer\tO\nhas\tO\nset\tO\nme\tO\nup\tO\nwith\tO\nFREE\tT-1\nrecovery\tB-aspectTerm\ndiscs\tI-aspectTerm\n,\tO\nwhen\tT-0\nthey\tT-0\nare\tT-0\navailable\tT-0\nsince\tO\nI\tO\nasked\tT-2\n.\tO\n\nI\tO\nalso\tO\npurchased\tT-1\nOffice\tB-aspectTerm\nMax\tI-aspectTerm\n's\tI-aspectTerm\n\"\tI-aspectTerm\nMax\tI-aspectTerm\nAssurance\tI-aspectTerm\n\"\tI-aspectTerm\nwith\tO\nthe\tO\n\"\tO\nno\tT-2\nlemon\tT-2\n\"\tO\nclause\tT-3\n.\tT-0\n\nI\tO\neventually\tO\ndid\tT-2\nthe\tT-2\nmigration\tT-2\nfrom\tO\nmy\tO\niMac\tB-aspectTerm\nbackup\tI-aspectTerm\ndisc\tI-aspectTerm\nwhich\tT-3\nuses\tT-3\nUSB\tT-3\n.\tT-0\n\nI\tO\neventually\tO\ndid\tO\nthe\tO\nmigration\tT-0\nfrom\tO\nmy\tO\niMac\tT-1\nbackup\tT-2\ndisc\tT-3\nwhich\tT-3\nuses\tT-3\nUSB\tB-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nseems\tO\nto\tO\nbe\tO\nvery\tO\ngood\tT-0\n,\tO\nand\tO\nhave\tO\nhad\tO\nno\tO\nissues\tO\nwith\tO\nit\tO\n.\tO\n\nEnabling\tT-0\nthe\tO\nbattery\tB-aspectTerm\ntimer\tI-aspectTerm\nis\tO\nuseless\tT-1\n.\tO\n\nTemperatures\tB-aspectTerm\non\tO\nthe\tO\noutside\tT-1\nwere\tO\nalright\tO\nbut\tO\ni\tO\ndid\tO\nnot\tO\ntrack\tO\nin\tO\nCore\tO\nProcessing\tO\nUnit\tO\ntemperatures\tT-0\n.\tO\n\nTemperatures\tO\non\tO\nthe\tO\noutside\tO\nwere\tO\nalright\tO\nbut\tO\ni\tO\ndid\tO\nnot\tO\ntrack\tT-1\nin\tT-1\nCore\tB-aspectTerm\nProcessing\tI-aspectTerm\nUnit\tI-aspectTerm\ntemperatures\tI-aspectTerm\n.\tT-0\n\nGoing\tO\nto\tO\nbring\tO\nit\tO\nto\tO\nservice\tB-aspectTerm\ntoday\tO\n.\tT-0\n\nThere\tO\nis\tO\nno\tO\nneed\tO\nto\tO\npurchase\tT-1\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\nfor\tI-aspectTerm\nMac\tI-aspectTerm\n,\tO\nwhich\tO\nsaves\tT-0\nme\tO\na\tO\nlot\tO\nof\tO\ntime\tO\nand\tO\nmoney\tO\n.\tO\n\nBut\tO\nwe\tO\nhad\tO\npaid\tT-1\nfor\tO\nbluetooth\tB-aspectTerm\n,\tO\nand\tO\nthere\tO\nwas\tO\nnone\tT-2\n.\tT-0\n\nSo\tO\n,\tO\nI\tO\npaid\tT-0\na\tO\nvisit\tO\nto\tO\nLG\tB-aspectTerm\nnotebook\tI-aspectTerm\nservice\tI-aspectTerm\ncenter\tI-aspectTerm\nat\tO\nAlexandra\tO\nRoad\tO\n,\tO\nhoping\tO\nthey\tO\ncan\tO\nmake\tO\nthe\tO\nhinge\tT-1\ntighter\tT-1\n.\tO\n\nSo\tO\n,\tO\nI\tO\npaid\tO\na\tO\nvisit\tO\nto\tO\nLG\tO\nnotebook\tT-0\nservice\tT-0\ncenter\tT-0\nat\tO\nAlexandra\tO\nRoad\tO\n,\tO\nhoping\tO\nthey\tO\ncan\tO\nmake\tO\nthe\tO\nhinge\tB-aspectTerm\ntighter\tT-1\n.\tO\n\nIt\tO\nis\tO\nalways\tO\nreliable\tT-0\n,\tO\nnever\tT-1\nbugged\tT-2\nand\tO\nresponds\tB-aspectTerm\nwell\tO\n.\tO\n\nAfter\tO\nabout\tO\na\tO\nweek\tO\nI\tO\nfinally\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nthe\tO\nmotherboard\tB-aspectTerm\nhad\tO\nfailed\tT-0\nand\tO\nso\tO\nthey\tO\ninstalled\tT-1\na\tO\nnew\tO\nmotherboard\tT-2\n.\tO\n\nAfter\tO\nabout\tO\na\tO\nweek\tO\nI\tO\nfinally\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nwas\tO\ntold\tO\nthat\tO\nthe\tO\nmotherboard\tT-0\nhad\tO\nfailed\tT-2\nand\tO\nso\tO\nthey\tO\ninstalled\tT-1\na\tO\nnew\tO\nmotherboard\tB-aspectTerm\n.\tO\n\nthey\tO\nhad\tO\nto\tO\nreplace\tO\nthe\tO\nmotherboard\tB-aspectTerm\nin\tO\nApril\tT-0\n\nYes\tO\n,\tO\nthe\tO\ncomputer\tO\nwas\tO\nlight\tO\nweight\tO\n,\tO\nless\tO\nexpensive\tO\nthan\tO\nthe\tO\naverage\tT-1\nlaptop\tO\n,\tO\nand\tO\nwas\tO\npretty\tT-0\nself\tO\nexplantory\tO\nin\tO\nuse\tB-aspectTerm\n.\tO\n\nAlso\tO\n,\tO\nif\tO\nyou\tO\nneed\tO\nto\tO\ntalk\tO\nto\tO\na\tO\nrepresentive\tB-aspectTerm\nat\tI-aspectTerm\nMicrosoft\tI-aspectTerm\n,\tO\nthere\tO\nis\tO\na\tO\ncharge\tO\n,\tO\nwhich\tO\nI\tO\nbelieve\tT-0\nis\tO\nrobbery\tO\n,\tO\nsince\tO\nyou\tO\nare\tO\ncharged\tO\nenormous\tO\namounts\tO\nfor\tO\na\tO\nvery\tO\nbadly\tO\ndesigned\tT-1\nsystem\tO\n,\tO\nwhich\tO\nmost\tO\npeople\tO\nwould\tO\nhave\tO\nwent\tO\nwith\tO\nXP\tO\nif\tO\nthey\tO\ncould\tO\n.\tO\n\nAlso\tO\n,\tO\nif\tO\nyou\tO\nneed\tO\nto\tO\ntalk\tO\nto\tO\na\tO\nrepresentive\tO\nat\tO\nMicrosoft\tT-0\n,\tO\nthere\tO\nis\tO\na\tO\ncharge\tO\n,\tO\nwhich\tO\nI\tO\nbelieve\tO\nis\tO\nrobbery\tO\n,\tO\nsince\tO\nyou\tO\nare\tO\ncharged\tT-1\nenormous\tT-1\namounts\tT-1\nfor\tO\na\tO\nvery\tO\nbadly\tO\ndesigned\tT-2\nsystem\tB-aspectTerm\n,\tO\nwhich\tO\nmost\tO\npeople\tO\nwould\tO\nhave\tO\nwent\tO\nwith\tO\nXP\tO\nif\tO\nthey\tO\ncould\tO\n.\tO\n\nAlso\tO\n,\tO\nif\tO\nyou\tO\nneed\tO\nto\tO\ntalk\tO\nto\tO\na\tO\nrepresentive\tO\nat\tO\nMicrosoft\tT-0\n,\tO\nthere\tO\nis\tO\na\tO\ncharge\tO\n,\tO\nwhich\tO\nI\tO\nbelieve\tO\nis\tO\nrobbery\tO\n,\tO\nsince\tO\nyou\tO\nare\tO\ncharged\tO\nenormous\tO\namounts\tO\nfor\tO\na\tO\nvery\tO\nbadly\tO\ndesigned\tO\nsystem\tT-1\n,\tO\nwhich\tO\nmost\tO\npeople\tO\nwould\tO\nhave\tO\nwent\tO\nwith\tO\nXP\tB-aspectTerm\nif\tO\nthey\tO\ncould\tO\n.\tO\n\nI\tO\nlove\tT-1\nWIndows\tB-aspectTerm\n7\tI-aspectTerm\nwhich\tT-0\nis\tO\na\tO\nvast\tO\nimprovment\tT-2\nover\tO\nVista\tO\n.\tO\n\nI\tO\nlove\tO\nWIndows\tO\n7\tO\nwhich\tO\nis\tO\na\tO\nvast\tT-1\nimprovment\tT-1\nover\tO\nVista\tB-aspectTerm\n.\tT-0\n\nKeyboard\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nvery\tO\nquiet\tT-0\nfor\tO\nall\tO\nthe\tO\ntyping\tT-1\nthat\tO\nI\tO\ndo\tO\n.\tO\n\nDell\tB-aspectTerm\n's\tI-aspectTerm\ncustomer\tI-aspectTerm\ndisservice\tI-aspectTerm\nis\tO\nan\tO\ninsult\tO\nto\tO\nit\tO\n's\tO\ncustomers\tT-1\nwho\tO\npay\tO\ngood\tO\nmoney\tO\nfor\tO\nshoddy\tT-0\nproducts\tT-2\n.\tO\n\nIt\tO\nhad\tO\na\tO\ncooling\tT-0\nsystem\tO\nmalfunction\tT-1\nafter\tO\n10\tO\nminutes\tO\nof\tO\ngeneral\tO\nuse\tB-aspectTerm\n,\tO\nand\tO\nwould\tO\nnot\tO\nmove\tO\npast\tO\nthis\tO\nerror\tT-2\n.\tO\n\nI\tO\ncan\tO\nrender\tO\nAVCHD\tO\nmovies\tO\nwith\tO\nlittle\tT-0\neffort\tO\n,\tO\nwhich\tO\nwas\tO\na\tO\nproblem\tO\nfor\tO\nmost\tO\npc\tO\n's\tO\nunless\tO\nyou\tO\nhad\tO\na\tO\nquad\tB-aspectTerm\ncore\tI-aspectTerm\nI7\tI-aspectTerm\n.\tO\n\nAfter\tO\ntalking\tT-0\nit\tT-0\nover\tT-0\nwith\tO\nthe\tO\nvery\tO\nknowledgeable\tO\nsales\tB-aspectTerm\nassociate\tI-aspectTerm\n,\tO\nI\tO\nchose\tO\nthe\tO\nMacBook\tO\nPro\tO\nover\tO\nthe\tO\nwhite\tO\nMacBook\tO\n.\tO\n\nIf\tO\nyou\tO\nreally\tO\nwant\tO\na\tO\nbang\tO\n-\tO\nup\tO\nsystem\tB-aspectTerm\nand\tO\ndo\tO\nn't\tO\nneed\tO\nto\tO\nrun\tO\nWindows\tT-0\napplications\tT-1\n,\tO\ngo\tO\nwith\tO\nan\tO\nApple\tT-2\n;\tO\n\nIf\tO\nyou\tO\nreally\tO\nwant\tO\na\tO\nbang\tO\n-\tO\nup\tO\nsystem\tO\nand\tO\ndo\tO\nn't\tO\nneed\tO\nto\tO\nrun\tT-0\nWindows\tB-aspectTerm\napplications\tI-aspectTerm\n,\tO\ngo\tO\nwith\tO\nan\tO\nApple\tO\n;\tO\n\nYou\tO\nwo\tO\nn't\tO\nhave\tO\nto\tO\nspend\tO\ngobs\tO\nof\tO\nmoney\tO\non\tO\nsome\tO\ninefficient\tT-2\nvirus\tB-aspectTerm\nprogram\tI-aspectTerm\nthat\tO\nneeds\tT-3\nto\tT-3\nbe\tT-3\nupdated\tT-3\nevery\tO\nmonth\tO\nand\tO\nthat\tO\nconstantly\tO\ndrains\tT-1\nyour\tO\nwallet\tO\n.\tO\n\nIt\tT-1\nweighed\tB-aspectTerm\nlike\tO\nseven\tO\npounds\tO\nor\tO\nsomething\tT-0\nlike\tO\nthat\tO\n.\tO\n\nIt\tO\nweighed\tT-0\nlike\tO\nseven\tB-aspectTerm\npounds\tI-aspectTerm\nor\tO\nsomething\tO\nlike\tO\nthat\tO\n.\tO\n\nYou\tO\nmay\tO\nneed\tT-1\nto\tO\nspecial\tT-0\norder\tO\na\tO\nbag\tB-aspectTerm\n.\tO\n\nIt\tO\n's\tO\ncolor\tB-aspectTerm\nis\tT-1\neven\tT-0\ncool\tT-2\n.\tO\n\nkeys\tB-aspectTerm\nare\tO\nall\tO\nin\tO\nweird\tT-0\nplaces\tT-0\nand\tO\nis\tO\nway\tO\ntoo\tO\nlarge\tT-1\nfor\tO\nthe\tO\nway\tO\nit\tO\nis\tO\ndesigned\tT-2\n.\tO\n\nkeys\tO\nare\tO\nall\tO\nin\tO\nweird\tO\nplaces\tO\nand\tO\nis\tO\nway\tO\ntoo\tO\nlarge\tT-1\nfor\tO\nthe\tO\nway\tT-0\nit\tT-0\nis\tT-0\ndesigned\tB-aspectTerm\n.\tO\n\nYes\tO\n,\tO\na\tO\nMac\tO\nis\tO\nmuch\tO\nmore\tO\nmoney\tO\nthan\tO\nthe\tO\naverage\tO\nlaptop\tO\nout\tO\nthere\tO\n,\tO\nbut\tO\nthere\tO\nis\tO\nno\tO\ncomparison\tT-0\nin\tO\nstyle\tB-aspectTerm\n,\tO\nspeed\tO\nand\tO\njust\tO\ncool\tO\nfactor\tO\n.\tO\n\nYes\tO\n,\tO\na\tO\nMac\tO\nis\tO\nmuch\tO\nmore\tO\nmoney\tO\nthan\tO\nthe\tO\naverage\tO\nlaptop\tO\nout\tO\nthere\tO\n,\tO\nbut\tO\nthere\tO\nis\tO\nno\tO\ncomparison\tT-0\nin\tO\nstyle\tO\n,\tO\nspeed\tB-aspectTerm\nand\tO\njust\tO\ncool\tO\nfactor\tO\n.\tO\n\nThe\tT-0\nkeyboard\tB-aspectTerm\nfeels\tO\ngood\tO\nand\tO\nI\tO\ntype\tT-1\njust\tT-1\nfine\tT-1\non\tT-1\nit\tO\n.\tO\n\nI\tO\nthought\tO\nthe\tO\nwhite\tO\nMac\tO\ncomputers\tO\nlooked\tT-0\ndirty\tO\ntoo\tO\nquicly\tO\nwhere\tO\nyou\tO\nuse\tO\nthe\tO\nmousepad\tB-aspectTerm\nand\tO\nwhere\tO\nyou\tO\nplace\tO\nyour\tO\nhands\tO\nwhen\tO\ntyping\tO\n.\tO\n\nAnd\tO\nnot\tO\nto\tO\nmention\tO\nafter\tO\nusing\tO\nit\tO\nfor\tO\na\tO\nfew\tO\nmonths\tO\nor\tO\nso\tO\n,\tO\nthe\tO\nbattery\tB-aspectTerm\nwill\tO\nslowly\tO\nless\tO\nand\tO\nless\tO\nhold\tO\na\tO\ncharge\tO\nuntil\tO\nyou\tO\nca\tO\nn't\tO\nleave\tO\nit\tO\nunplugged\tT-0\nfor\tO\nmore\tO\nthan\tO\n5\tO\nminutes\tT-2\nwithout\tO\nthe\tO\nthing\tO\ndying\tT-1\n.\tO\n\nBEST\tO\nBUY\tO\n-\tO\n5\tO\nSTARS\tO\n+\tO\n+\tO\n+\tO\n(\tO\nsales\tB-aspectTerm\n,\tO\nservice\tO\n,\tO\nrespect\tO\nfor\tO\nold\tO\nmen\tO\nwho\tO\nare\tO\nn't\tO\nfamiliar\tT-0\nwith\tO\nthe\tO\ntechnology\tO\n)\tO\nDELL\tO\nCOMPUTERS\tT-1\n-\tO\n3\tO\nstars\tO\nDELL\tO\nSUPPORT\tT-2\n-\tO\nowes\tO\na\tO\nme\tO\na\tO\ncouple\tO\n\nBEST\tO\nBUY\tO\n-\tO\n5\tO\nSTARS\tO\n+\tO\n+\tO\n+\tO\n(\tO\nsales\tO\n,\tO\nservice\tB-aspectTerm\n,\tO\nrespect\tT-0\nfor\tO\nold\tO\nmen\tO\nwho\tO\nare\tO\nn't\tO\nfamiliar\tO\nwith\tO\nthe\tO\ntechnology\tO\n)\tO\nDELL\tO\nCOMPUTERS\tO\n-\tO\n3\tO\nstars\tO\nDELL\tO\nSUPPORT\tO\n-\tO\nowes\tO\na\tO\nme\tO\na\tO\ncouple\tO\n\nBEST\tO\nBUY\tO\n-\tO\n5\tO\nSTARS\tO\n+\tO\n+\tO\n+\tO\n(\tO\nsales\tO\n,\tO\nservice\tO\n,\tO\nrespect\tO\nfor\tO\nold\tO\nmen\tO\nwho\tO\nare\tO\nn't\tO\nfamiliar\tT-1\nwith\tO\nthe\tO\ntechnology\tO\n)\tO\nDELL\tO\nCOMPUTERS\tO\n-\tO\n3\tT-0\nstars\tT-0\nDELL\tB-aspectTerm\nSUPPORT\tI-aspectTerm\n-\tO\nowes\tO\na\tO\nme\tO\na\tO\ncouple\tO\n\nno\tO\ncomplaints\tO\nwith\tO\ntheir\tO\ndesktop\tT-1\n,\tO\nand\tO\nmaybe\tO\nbecause\tO\nit\tO\njust\tO\nsits\tO\non\tO\nyour\tO\ndesktop\tT-2\n,\tO\nand\tO\nyou\tO\ndo\tO\nn't\tO\ncarry\tO\nit\tO\naround\tO\n,\tO\nwhich\tO\ncould\tO\njar\tT-0\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\n,\tO\nor\tO\nthe\tO\nmotherboard\tO\n.\tO\n\nno\tO\ncomplaints\tO\nwith\tO\ntheir\tO\ndesktop\tT-0\n,\tO\nand\tO\nmaybe\tO\nbecause\tO\nit\tO\njust\tO\nsits\tO\non\tO\nyour\tO\ndesktop\tT-1\n,\tO\nand\tO\nyou\tO\ndo\tO\nn't\tO\ncarry\tO\nit\tO\naround\tO\n,\tO\nwhich\tO\ncould\tO\njar\tO\nthe\tO\nhard\tT-2\ndrive\tT-2\n,\tO\nor\tO\nthe\tO\nmotherboard\tB-aspectTerm\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tB-aspectTerm\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tO\nup\tO\nfor\tO\nit\tO\nin\tO\nspeed\tO\n,\tO\nconstruction\tO\nquality\tT-0\n,\tO\nand\tO\nlongevity\tO\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tO\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tO\nup\tO\nfor\tO\nit\tO\nin\tO\nspeed\tB-aspectTerm\n,\tO\nconstruction\tO\nquality\tT-0\n,\tO\nand\tO\nlongevity\tO\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tO\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tT-0\nup\tO\nfor\tO\nit\tO\nin\tO\nspeed\tT-1\n,\tO\nconstruction\tB-aspectTerm\nquality\tI-aspectTerm\n,\tO\nand\tO\nlongevity\tO\n.\tO\n\nYes\tO\n,\tO\nthey\tO\ncost\tO\nmore\tO\n,\tO\nbut\tO\nthey\tO\nmore\tO\nthan\tO\nmake\tT-0\nup\tT-0\nfor\tT-0\nit\tT-0\nin\tT-0\nspeed\tT-1\n,\tT-1\nconstruction\tT-1\nquality\tT-1\n,\tO\nand\tO\nlongevity\tB-aspectTerm\n.\tO\n\nSince\tO\nI\tO\nkeyboard\tT-0\nover\tO\n100\tO\nwpm\tO\n,\tO\nI\tO\nlook\tO\nfor\tO\na\tO\nunit\tO\nthat\tO\nhas\tO\na\tO\ncomfortble\tT-3\nkeyboard\tB-aspectTerm\n(\tO\nno\tO\nkeys\tT-1\nsticking\tO\nor\tO\nlagging\tO\n,\tO\nstrange\tO\nconfiguration\tT-2\nof\tO\n\"\tO\nextra\tO\nkey\tO\n\"\tO\n,\tO\netc\tO\n.\tO\n\nSince\tO\nI\tO\nkeyboard\tT-0\nover\tO\n100\tO\nwpm\tO\n,\tO\nI\tO\nlook\tO\nfor\tO\na\tO\nunit\tO\nthat\tO\nhas\tO\na\tO\ncomfortble\tO\nkeyboard\tT-1\n(\tO\nno\tO\nkeys\tB-aspectTerm\nsticking\tO\nor\tO\nlagging\tO\n,\tO\nstrange\tO\nconfiguration\tT-2\nof\tO\n\"\tO\nextra\tO\nkey\tO\n\"\tO\n,\tO\netc\tO\n.\tO\n\nSince\tO\nI\tO\nkeyboard\tO\nover\tO\n100\tO\nwpm\tT-1\n,\tO\nI\tO\nlook\tO\nfor\tO\na\tO\nunit\tO\nthat\tO\nhas\tO\na\tO\ncomfortble\tO\nkeyboard\tT-0\n(\tO\nno\tO\nkeys\tO\nsticking\tO\nor\tO\nlagging\tO\n,\tO\nstrange\tO\nconfiguration\tB-aspectTerm\nof\tI-aspectTerm\n\"\tI-aspectTerm\nextra\tI-aspectTerm\nkey\tI-aspectTerm\n\"\tI-aspectTerm\n,\tO\netc\tO\n.\tO\n\n)\tO\nI\tO\nalso\tO\ntried\tO\nthe\tO\ntouch\tB-aspectTerm\npad\tI-aspectTerm\nand\tO\ncompared\tO\nit\tO\nto\tO\nother\tO\nnetbooks\tT-0\nin\tO\nthe\tO\nstore\tO\n.\tO\n\nIt\tO\nabsolutely\tO\nis\tO\nmore\tO\nexpensive\tO\nthan\tO\nmost\tO\nPC\tO\nlaptops\tT-0\n,\tO\nbut\tO\nthe\tO\nease\tO\nof\tO\nuse\tB-aspectTerm\n,\tO\nsecurity\tT-1\n,\tO\nand\tO\nminimal\tO\nproblems\tO\nthat\tO\nhave\tO\narisen\tO\nmake\tO\nit\tO\nwell\tO\nworth\tO\nthe\tO\npricetag\tO\n.\tO\n\nIt\tO\nabsolutely\tO\nis\tO\nmore\tO\nexpensive\tO\nthan\tO\nmost\tO\nPC\tT-0\nlaptops\tT-3\n,\tO\nbut\tO\nthe\tO\nease\tT-1\nof\tT-1\nuse\tT-1\n,\tO\nsecurity\tB-aspectTerm\n,\tO\nand\tO\nminimal\tT-2\nproblems\tT-2\nthat\tO\nhave\tO\narisen\tO\nmake\tO\nit\tO\nwell\tO\nworth\tO\nthe\tO\npricetag\tO\n.\tO\n\nIt\tO\nabsolutely\tO\nis\tO\nmore\tO\nexpensive\tO\nthan\tO\nmost\tO\nPC\tT-0\nlaptops\tT-0\n,\tO\nbut\tO\nthe\tO\nease\tO\nof\tO\nuse\tO\n,\tO\nsecurity\tT-1\n,\tO\nand\tO\nminimal\tO\nproblems\tO\nthat\tO\nhave\tO\narisen\tO\nmake\tO\nit\tO\nwell\tO\nworth\tO\nthe\tO\npricetag\tB-aspectTerm\n.\tO\n\nÂ\tO\nIt\tO\ngets\tO\nstuck\tO\nall\tO\nof\tO\nthe\tO\ntime\tO\nyou\tO\nuse\tB-aspectTerm\nit\tO\n,\tO\nand\tO\nyou\tO\nhave\tO\nto\tO\nkeep\tO\ntapping\tT-1\non\tO\nit\tO\nto\tO\nget\tO\nit\tO\nto\tO\nwork\tO\n.\tT-0\n\nÂ\tO\nIt\tO\ngets\tO\nstuck\tO\nall\tO\nof\tO\nthe\tO\ntime\tO\nyou\tO\nuse\tO\nit\tT-0\n,\tT-0\nand\tT-0\nyou\tO\nhave\tO\nto\tO\nkeep\tO\ntapping\tO\non\tT-1\nit\tT-1\nto\tT-1\nget\tO\nit\tO\nto\tO\nwork\tB-aspectTerm\n.\tO\n\nlots\tT-0\nof\tO\npreloaded\tB-aspectTerm\nsoftware\tI-aspectTerm\n.\tO\n\nI\tO\nwish\tO\nit\tO\nhad\tT-1\na\tT-1\nwebcam\tB-aspectTerm\nthough\tT-0\n,\tO\nthen\tO\nit\tO\nwould\tO\nbe\tO\nperfect\tO\n!\tO\n\nMy\tO\nfavorite\tO\npart\tO\nof\tO\nthis\tO\ncomputer\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\na\tO\nvga\tB-aspectTerm\nport\tI-aspectTerm\nso\tO\nI\tO\ncan\tO\nconnect\tT-1\nit\tO\nto\tT-2\na\tO\nbigger\tT-0\nscreen\tO\n.\tO\n\nMy\tO\nfavorite\tO\npart\tO\nof\tO\nthis\tO\ncomputer\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\na\tO\nvga\tO\nport\tO\nso\tO\nI\tO\ncan\tO\nconnect\tT-0\nit\tO\nto\tO\na\tO\nbigger\tO\nscreen\tB-aspectTerm\n.\tO\n\nAnother\tO\nthing\tO\nI\tO\nmight\tO\nadd\tT-0\nis\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nis\tO\nexcellent\tT-1\n.\tO\n\nOne\tO\ndrawback\tO\n,\tO\nI\tO\nwish\tO\nthe\tO\nkeys\tB-aspectTerm\nwere\tO\nbacklit\tT-0\n.\tO\n\nAcer\tO\nwas\tO\nno\tO\nhelp\tO\nand\tO\nGarmin\tO\ncould\tO\nnot\tO\ndetermine\tT-0\nthe\tO\nproblem(after\tO\nspending\tO\nabout\tO\n2\tO\nhours\tO\nwith\tO\nme\tO\n)\tO\n,\tO\nso\tO\nI\tO\nreturned\tO\nit\tO\nand\tO\npurchased\tO\na\tO\nToshiba\tT-1\nR700\tT-1\nthat\tO\nseems\tO\neven\tO\nnicer\tO\nand\tO\nI\tO\nwas\tO\nable\tO\nto\tO\nload\tO\nall\tO\nof\tO\nmy\tO\nsoftware\tB-aspectTerm\nwith\tO\nno\tO\nproblem\tO\n.\tO\n\nI\tO\nwish\tO\nthe\tO\nvolume\tB-aspectTerm\ncould\tO\nbe\tO\nlouder\tT-1\nand\tO\nthe\tO\nmouse\tO\ndid\tO\nnt\tO\nbreak\tO\nafter\tO\nonly\tO\na\tO\nmonth\tT-0\n.\tO\n\nI\tO\nwish\tO\nthe\tO\nvolume\tT-1\ncould\tO\nbe\tO\nlouder\tO\nand\tO\nthe\tO\nmouse\tB-aspectTerm\ndid\tO\nnt\tO\nbreak\tT-0\nafter\tO\nonly\tO\na\tO\nmonth\tO\n.\tO\n\nI\tO\nplay\tO\na\tO\nlot\tO\nof\tO\ncasual\tO\ngames\tT-0\nonline\tO\n,\tO\nand\tO\nthe\tO\ntouchpad\tB-aspectTerm\nis\tO\nvery\tO\nresponsive\tT-1\n.\tO\n\nGranted\tT-0\n,\tO\nit\tO\n's\tO\nstill\tO\na\tO\nvery\tO\nnew\tO\nlaptop\tO\nbut\tO\nin\tO\ncomparison\tO\nto\tO\nmy\tO\nprevious\tO\nlaptops\tT-1\nand\tO\ndesktops\tO\n,\tO\nmy\tO\nMac\tO\nboots\tB-aspectTerm\nup\tI-aspectTerm\nnoticeably\tO\nquicker\tO\n.\tO\n\nIt\tO\ncaught\tO\na\tO\nvirus\tO\nthat\tO\ncompletely\tO\nwiped\tT-0\nout\tT-0\nmy\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nin\tO\na\tO\nmatter\tT-1\nof\tO\nhours\tO\n.\tO\n\nIt\tO\nis\tO\neverything\tO\nI\tO\n'd\tO\nhoped\tT-0\nit\tO\nwould\tO\nbe\tO\nfrom\tT-2\na\tO\nlook\tB-aspectTerm\nand\tI-aspectTerm\nfeel\tI-aspectTerm\nstandpoint\tI-aspectTerm\n,\tO\nbut\tO\nsomehow\tO\na\tO\nbit\tO\nmore\tO\nsturdy\tT-3\n.\tT-1\n\nthe\tO\nonly\tO\nfact\tO\ni\tO\ndo\tO\nnt\tO\nlike\tO\nabout\tO\napples\tO\nis\tT-1\nthey\tT-1\ngenerally\tT-1\nuse\tT-1\nsafari\tB-aspectTerm\nand\tO\ni\tO\ndo\tO\nnt\tO\nuse\tO\nsafari\tO\nbut\tO\nafter\tO\ni\tO\ninstall\tO\nMozzilla\tO\nfirfox\tO\ni\tO\nlove\tO\nevery\tO\nsingle\tO\nbit\tO\nabout\tO\nit\tO\n.\tT-0\n\nthe\tO\nonly\tO\nfact\tO\ni\tO\ndo\tO\nnt\tO\nlike\tT-0\nabout\tO\napples\tO\nis\tO\nthey\tO\ngenerally\tO\nuse\tO\nsafari\tT-1\nand\tO\ni\tO\ndo\tO\nnt\tO\nuse\tO\nsafari\tB-aspectTerm\nbut\tO\nafter\tO\ni\tO\ninstall\tT-2\nMozzilla\tO\nfirfox\tO\ni\tO\nlove\tO\nevery\tO\nsingle\tO\nbit\tO\nabout\tO\nit\tO\n.\tO\n\nthe\tO\nonly\tO\nfact\tO\ni\tO\ndo\tO\nnt\tO\nlike\tO\nabout\tO\napples\tO\nis\tO\nthey\tO\ngenerally\tO\nuse\tO\nsafari\tO\nand\tO\ni\tO\ndo\tO\nnt\tO\nuse\tO\nsafari\tO\nbut\tO\nafter\tO\ni\tO\ninstall\tT-1\nMozzilla\tB-aspectTerm\nfirfox\tI-aspectTerm\ni\tT-0\nlove\tT-0\nevery\tO\nsingle\tO\nbit\tO\nabout\tO\nit\tO\n.\tO\n\nThe\tO\nBluetooth\tB-aspectTerm\nwas\tO\nnot\tO\nthere\tO\nat\tO\nall\tO\n,\tO\nand\tO\nthe\tO\nfingerprint\tT-0\nreader\tT-0\ndriver\tT-1\nwould\tO\nbe\tO\nthere\tO\n,\tO\nbut\tO\nthe\tO\nsoftware\tT-2\nwould\tO\nhang\tO\nafter\tO\ninstallation\tT-3\nwas\tO\n1/2\tO\nway\tO\ndone\tO\n.\tO\n\nThe\tO\nBluetooth\tO\nwas\tO\nnot\tO\nthere\tO\nat\tO\nall\tO\n,\tO\nand\tO\nthe\tO\nfingerprint\tB-aspectTerm\nreader\tI-aspectTerm\ndriver\tI-aspectTerm\nwould\tO\nbe\tO\nthere\tO\n,\tO\nbut\tO\nthe\tO\nsoftware\tT-0\nwould\tO\nhang\tO\nafter\tO\ninstallation\tO\nwas\tO\n1/2\tO\nway\tO\ndone\tO\n.\tT-1\n\nThe\tO\nBluetooth\tT-1\nwas\tO\nnot\tO\nthere\tO\nat\tO\nall\tO\n,\tO\nand\tO\nthe\tO\nfingerprint\tT-2\nreader\tT-2\ndriver\tT-2\nwould\tO\nbe\tO\nthere\tO\n,\tO\nbut\tO\nthe\tO\nsoftware\tB-aspectTerm\nwould\tT-0\nhang\tT-0\nafter\tO\ninstallation\tO\nwas\tO\n1/2\tO\nway\tO\ndone\tO\n.\tO\n\nGreat\tO\nbattery\tT-1\n,\tO\nspeed\tB-aspectTerm\n,\tO\ndisplay\tT-0\n.\tT-0\n\nGreat\tO\nbattery\tT-0\n,\tO\nspeed\tT-1\n,\tO\ndisplay\tB-aspectTerm\n.\tO\n\nThe\tT-1\ndelivery\tB-aspectTerm\nwas\tT-2\nfast\tT-2\n,\tO\nand\tO\nI\tO\nwould\tO\nnot\tO\nhesitate\tO\nto\tO\npurchase\tO\nthis\tO\nlaptop\tO\nagain\tO\n.\tO\n\nI\tO\n've\tO\nbeen\tO\nimpressed\tO\nwith\tO\nthe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nand\tO\nthe\tO\nperformance\tT-0\nfor\tO\nsuch\tO\na\tO\nsmall\tO\namount\tO\nof\tO\nmemory\tT-1\n.\tO\n\nI\tO\n've\tO\nbeen\tO\nimpressed\tO\nwith\tO\nthe\tO\nbattery\tO\nlife\tO\nand\tO\nthe\tO\nperformance\tB-aspectTerm\nfor\tO\nsuch\tO\na\tO\nsmall\tO\namount\tO\nof\tO\nmemory\tT-0\n.\tO\n\nI\tO\n've\tO\nbeen\tO\nimpressed\tT-0\nwith\tO\nthe\tO\nbattery\tT-1\nlife\tO\nand\tO\nthe\tO\nperformance\tO\nfor\tO\nsuch\tO\na\tO\nsmall\tO\namount\tO\nof\tO\nmemory\tB-aspectTerm\n.\tO\n\nIt\tT-1\n's\tT-1\napplications\tB-aspectTerm\nare\tO\nterrific\tO\n,\tO\nincluding\tO\nthe\tO\nreplacements\tT-0\nfor\tO\nMicrosoft\tO\noffice\tO\n.\tO\n\nIt\tO\n's\tO\napplications\tT-0\nare\tO\nterrific\tO\n,\tO\nincluding\tO\nthe\tO\nreplacements\tT-1\nfor\tO\nMicrosoft\tB-aspectTerm\noffice\tI-aspectTerm\n.\tO\n\nthey\tO\nimproved\tO\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tB-aspectTerm\n,\tO\nappearance\tT-0\n,\tO\ncooling\tT-1\nsystem\tT-1\n,\tO\ngraphics\tT-2\ncard\tT-2\n,\tO\netc\tO\n.\tO\n\nthey\tO\nimproved\tT-0\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tO\n,\tO\nappearance\tB-aspectTerm\n,\tO\ncooling\tO\nsystem\tO\n,\tO\ngraphics\tO\ncard\tO\n,\tO\netc\tO\n.\tO\n\nthey\tO\nimproved\tT-1\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tT-0\n,\tO\nappearance\tO\n,\tO\ncooling\tB-aspectTerm\nsystem\tI-aspectTerm\n,\tO\ngraphics\tO\ncard\tO\n,\tO\netc\tO\n.\tO\n\nthey\tO\nimproved\tT-4\nnothing\tO\nelse\tO\nsuch\tO\nas\tO\nResolution\tT-0\n,\tO\nappearance\tT-1\n,\tO\ncooling\tT-2\nsystem\tT-2\n,\tO\ngraphics\tB-aspectTerm\ncard\tI-aspectTerm\n,\tO\netc\tO\n.\tT-3\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nwebcam\tI-aspectTerm\nand\tO\nbuilt\tT-2\n-\tT-2\nin\tT-2\nmic\tT-2\nwere\tO\nshorting\tT-0\nout\tT-0\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tT-1\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tO\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tO\nand\tO\nmic\tO\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tO\n-\tO\nin\tO\nwebcam\tO\nand\tO\nbuilt\tB-aspectTerm\n-\tI-aspectTerm\nin\tI-aspectTerm\nmic\tI-aspectTerm\nwere\tO\nshorting\tT-0\nout\tO\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tO\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tO\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tO\nand\tO\nmic\tO\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tO\n-\tO\nin\tO\nwebcam\tO\nand\tO\nbuilt\tO\n-\tO\nin\tO\nmic\tO\nwere\tO\nshorting\tT-0\nout\tO\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tO\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tT-1\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tB-aspectTerm\nand\tO\nmic\tO\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nI\tO\ngot\tO\nit\tO\nback\tO\nand\tO\nmy\tO\nbuilt\tO\n-\tO\nin\tO\nwebcam\tT-0\nand\tO\nbuilt\tO\n-\tO\nin\tO\nmic\tO\nwere\tO\nshorting\tO\nout\tO\nanytime\tO\nI\tO\ntouched\tO\nthe\tO\nlid\tO\n,\tO\n(\tO\nmind\tO\nyou\tO\nthis\tO\nwas\tO\nmy\tO\nmeans\tO\nof\tO\ncommunication\tO\nwith\tO\nmy\tO\nfiance\tO\nwho\tO\nwas\tO\ndeployed\tO\n)\tO\nbut\tO\nI\tO\nsuffered\tO\nthru\tO\nit\tO\nand\tO\nwould\tO\nconstandly\tO\nhave\tO\nto\tO\nreset\tO\nthe\tO\ncomputer\tO\nto\tO\nbe\tO\nable\tO\nto\tO\nuse\tO\nmy\tO\ncam\tO\nand\tO\nmic\tB-aspectTerm\nanytime\tO\nthey\tO\nwent\tO\nout\tO\n.\tO\n\nMy\tO\ndad\tO\nhas\tO\none\tO\nof\tO\nthe\tO\nvery\tO\nfirst\tO\nToshibas\tO\never\tO\nmade\tO\n,\tO\nyes\tO\nits\tO\nabit\tO\nslow\tO\nnow\tO\nbut\tO\nstill\tT-0\nworks\tT-1\nwell\tO\nand\tO\ni\tO\nhooked\tO\nto\tO\nmy\tO\nethernet\tB-aspectTerm\n!\tO\n\nMostly\tO\nI\tO\nlove\tT-0\nthe\tO\ndrag\tB-aspectTerm\nand\tI-aspectTerm\ndrop\tI-aspectTerm\nfeature\tI-aspectTerm\n.\tT-1\n\noh\tO\nyeah\tO\n,\tO\nand\tO\nif\tO\nthe\tO\nfancy\tO\nwebcam\tB-aspectTerm\nbreaks\tO\nguess\tO\nwho\tO\nyou\tO\nhave\tO\nto\tO\nsend\tO\nit\tO\nto\tO\nto\tO\nget\tO\nit\tO\nfixed\tT-0\n?\tT-1\n\nI\tO\nordered\tO\nthrough\tO\nMacMall\tT-0\n,\tO\nwhich\tO\nsaved\tO\nme\tO\nthe\tO\nsales\tB-aspectTerm\ntax\tI-aspectTerm\nI\tO\nwould\tO\nhave\tO\nincurred\tO\nbuying\tO\nlocally\tO\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tO\nsoftware\tB-aspectTerm\npackages\tI-aspectTerm\nthat\tO\ncame\tO\nfor\tO\nfree\tO\nincluding\tO\niWork\tT-0\n,\tO\nGarageBand\tT-1\n,\tO\nand\tO\niMovie\tT-2\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tO\nsoftware\tT-2\npackages\tO\nthat\tO\ncame\tO\nfor\tO\nfree\tO\nincluding\tO\niWork\tB-aspectTerm\n,\tO\nGarageBand\tT-0\n,\tO\nand\tO\niMovie\tT-1\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tT-0\nsoftware\tT-3\npackages\tT-3\nthat\tO\ncame\tO\nfor\tO\nfree\tT-1\nincluding\tT-2\niWork\tO\n,\tO\nGarageBand\tB-aspectTerm\n,\tO\nand\tO\niMovie\tO\n.\tO\n\nOf\tO\ncourse\tO\n,\tO\nI\tO\nalso\tO\nhave\tO\nseveral\tO\ngreat\tO\nsoftware\tT-0\npackages\tO\nthat\tO\ncame\tO\nfor\tO\nfree\tO\nincluding\tO\niWork\tT-1\n,\tO\nGarageBand\tO\n,\tO\nand\tO\niMovie\tB-aspectTerm\n.\tO\n\nThe\tT-0\nscreen\tB-aspectTerm\nis\tO\nvery\tO\nlarge\tO\nand\tO\ncrystal\tO\nclear\tO\nwith\tO\namazing\tO\ncolors\tT-1\nand\tO\nresolution\tO\n.\tO\n\nThe\tO\nscreen\tT-1\nis\tO\nvery\tO\nlarge\tO\nand\tO\ncrystal\tO\nclear\tO\nwith\tO\namazing\tT-0\ncolors\tT-0\nand\tO\nresolution\tB-aspectTerm\n.\tO\n\nAfter\tO\na\tO\nlittle\tO\nmore\tT-2\nthan\tO\na\tO\nyear\tO\nof\tO\nowning\tO\nmy\tO\nMacBook\tT-0\nPro\tT-0\n,\tO\nthe\tO\nmonitor\tB-aspectTerm\nhas\tO\ncompletely\tO\ndied\tT-1\n.\tO\n\nThe\tO\nbrand\tO\nof\tO\niTunes\tB-aspectTerm\nhas\tO\njust\tO\nbecome\tO\ningrained\tO\nin\tO\nour\tO\nlexicon\tT-0\nnow\tO\n,\tO\nbut\tO\nkeep\tO\nin\tO\nmind\tO\nthat\tO\nApple\tO\nstarted\tO\nit\tO\nall\tO\n.\tO\n\nSize\tB-aspectTerm\n:\tO\nI\tO\nknow\tT-0\n13\tO\nis\tO\nsmall\tO\n(\tO\nespecially\tO\nfor\tO\na\tO\ndesktop\tT-1\nreplacement\tO\n)\tO\nbut\tO\nwith\tO\nan\tO\nexternal\tO\nmonitor\tT-2\n,\tO\nwho\tO\ncares\tO\n.\tO\n\nSize\tO\n:\tO\nI\tO\nknow\tO\n13\tT-0\nis\tO\nsmall\tO\n(\tO\nespecially\tO\nfor\tO\na\tO\ndesktop\tT-1\nreplacement\tO\n)\tO\nbut\tO\nwith\tO\nan\tO\nexternal\tB-aspectTerm\nmonitor\tI-aspectTerm\n,\tO\nwho\tO\ncares\tO\n.\tO\n\nAdditional\tO\ncaveat\tO\n:\tO\nthe\tO\nbase\tB-aspectTerm\ninstallation\tI-aspectTerm\ncomes\tT-0\nwith\tO\nsome\tO\nToshiba\tT-2\n-\tT-2\nspecific\tT-2\nsoftware\tT-2\nthat\tO\nmay\tO\nor\tO\nmay\tO\nnot\tO\nbe\tO\nto\tO\na\tO\nuser\tT-1\n's\tT-1\nliking\tT-1\n.\tO\n\nAdditional\tO\ncaveat\tO\n:\tO\nthe\tO\nbase\tO\ninstallation\tO\ncomes\tO\nwith\tO\nsome\tO\nToshiba\tO\n-\tO\nspecific\tO\nsoftware\tB-aspectTerm\nthat\tT-0\nmay\tO\nor\tO\nmay\tO\nnot\tO\nbe\tO\nto\tO\na\tO\nuser\tO\n's\tO\nliking\tO\n.\tO\n\nÂ\tO\nTaking\tO\nit\tO\nback\tO\nto\tO\nBest\tO\nBuy\tO\nI\tO\nfound\tO\nthat\tO\na\tO\ntiny\tO\nplastic\tO\npiece\tO\ninside\tO\nhad\tO\nbroken\tO\n(\tO\nmanuf\tB-aspectTerm\nissue\tO\n)\tO\n.\tT-0\n\nThe\tT-0\ndisplay\tB-aspectTerm\nis\tO\nincredibly\tO\nbright\tT-1\n,\tO\nmuch\tO\nbrighter\tO\nthan\tO\nmy\tO\nPowerBook\tO\nand\tO\nvery\tO\ncrisp\tO\n.\tO\n\nThe\tO\nAMD\tB-aspectTerm\nTurin\tI-aspectTerm\nprocessor\tI-aspectTerm\nseems\tO\nto\tO\nalways\tO\nperform\tT-0\nso\tO\nmuch\tT-1\nbetter\tO\nthan\tO\nIntel\tO\n.\tO\n\nThe\tO\nAMD\tT-1\nTurin\tT-1\nprocessor\tT-1\nseems\tO\nto\tO\nalways\tO\nperform\tO\nso\tO\nmuch\tT-2\nbetter\tT-2\nthan\tO\nIntel\tB-aspectTerm\n.\tO\n\nÂ\tO\nAfter\tT-1\nthat\tO\nthe\tO\nsaid\tO\nit\tO\nwas\tO\nunder\tO\nwarranty\tB-aspectTerm\n.\tT-2\n\nThe\tO\nstart\tB-aspectTerm\nmenu\tI-aspectTerm\nis\tO\nnot\tO\nthe\tO\neasiest\tO\nthing\tT-0\nto\tT-0\nnavigate\tT-1\ndue\tO\nto\tO\nthe\tO\nstacking\tO\n.\tO\n\nThe\tO\nstart\tO\nmenu\tO\nis\tO\nnot\tO\nthe\tO\neasiest\tT-0\nthing\tO\nto\tO\nnavigate\tB-aspectTerm\ndue\tO\nto\tO\nthe\tO\nstacking\tO\n.\tO\n\nThe\tO\nservice\tB-aspectTerm\ntech\tI-aspectTerm\nsaid\tO\nhe\tO\nhad\tO\ntried\tO\nto\tO\nduplicate\tT-0\nthe\tO\ndamage\tO\nand\tO\nwas\tO\nn't\tO\nable\tO\nto\tO\nrecreate\tO\nit\tO\ntherefore\tO\nit\tO\nhad\tO\nto\tO\nbe\tO\ntheir\tO\ndefect\tO\n.\tO\n\nThe\tT-1\ntech\tB-aspectTerm\nstore\tI-aspectTerm\nI\tT-2\npurchased\tT-2\nthis\tT-2\nfrom\tT-2\nsent\tO\nit\tO\nback,,,,,eventually\tO\nI\tO\ngot\tO\na\tO\nnew\tT-0\nor\tT-0\nrepaired\tT-0\nmachine\tT-0\napproximately\tO\n3\tO\nweeks\tO\nlater\tO\n.\tO\n\nReally\tO\nlike\tO\nthe\tO\ntextured\tT-1\nsurface\tB-aspectTerm\nwhich\tO\nshows\tT-0\nno\tO\nfingerprints\tO\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\nbright\tO\nand\tO\nthe\tO\nkeyboard\tT-1\nis\tO\nnice\tT-0\n;\tO\n\nThe\tO\nscreen\tT-2\nis\tO\nbright\tT-1\nand\tO\nthe\tO\nkeyboard\tB-aspectTerm\nis\tO\nnice\tT-0\n;\tO\n\nBut\tO\nthe\tO\nmachine\tT-1\nis\tO\nawesome\tT-0\nand\tO\niLife\tB-aspectTerm\nis\tO\ngreat\tO\nand\tO\nI\tO\nlove\tO\nSnow\tO\nLeopard\tO\nX.\tO\n\nBut\tO\nthe\tO\nmachine\tT-1\nis\tO\nawesome\tO\nand\tO\niLife\tO\nis\tO\ngreat\tT-0\nand\tO\nI\tO\nlove\tO\nSnow\tB-aspectTerm\nLeopard\tI-aspectTerm\nX.\tI-aspectTerm\n\nHigh\tT-1\nprice\tB-aspectTerm\ntag\tI-aspectTerm\n,\tO\nhowever\tT-0\n.\tO\n\nI\tT-1\nthought\tT-1\nlearning\tT-1\nthe\tT-1\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nwould\tT-0\nbe\tO\nhard\tO\n,\tO\nbut\tO\nit\tO\nis\tO\neasily\tO\npicked\tO\nup\tO\nif\tO\nyou\tO\nare\tO\nfamiliar\tO\nwith\tO\na\tO\nPC\tT-2\n.\tO\n\nI\tO\nhad\tO\nstatic\tO\nin\tO\nthe\tO\noutput\tT-1\n,\tO\nand\tO\nI\tO\nhad\tO\nto\tO\nreduce\tO\nthe\tO\nsound\tB-aspectTerm\noutput\tI-aspectTerm\nquality\tI-aspectTerm\nto\tO\n\"\tO\nFM\tT-0\n\"\tO\nas\tO\nopposed\tT-2\nto\tT-2\nthe\tT-2\ndefault\tT-2\n\"\tO\nCD\tO\n.\tO\n\nI\tO\ncustom\tO\nordered\tO\nthe\tO\nmachine\tO\nfrom\tO\nHP\tO\nand\tO\ncould\tO\nNOT\tO\nunderstand\tT-0\nthe\tO\ntechie\tB-aspectTerm\ndue\tO\nto\tO\nhis\tO\naccent\tO\n.\tO\n\nIt\tO\nis\tO\neasy\tT-0\nto\tO\nuse\tB-aspectTerm\nand\tO\nlightweight\tT-1\n.\tO\n\nI\tT-1\nwent\tT-1\nto\tT-1\nToshiba\tB-aspectTerm\nonline\tI-aspectTerm\nhelp\tI-aspectTerm\nand\tO\nfound\tO\nsome\tO\nsuggestions\tO\nto\tO\nfix\tT-0\nit\tT-0\n.\tO\n\nThey\tT-0\nalso\tT-0\nhave\tT-0\na\tT-0\nlonger\tT-0\nservice\tB-aspectTerm\nlife\tI-aspectTerm\nthan\tO\nother\tO\ncomputers\tT-1\n(\tO\nI\tO\nhave\tO\nseveral\tO\nfriends\tO\nwho\tO\nstill\tO\nuse\tO\nthe\tO\nolder\tO\nApple\tO\nPowerBooks\tO\n)\tO\n.\tO\n\nIf\tO\nyou\tO\ncheck\tO\nyou\tO\nwill\tO\nfind\tO\nthe\tO\nsame\tO\nnotebook\tT-1\nwith\tO\nthe\tO\nabove\tO\nmissing\tT-0\nports\tB-aspectTerm\nand\tO\na\tT-2\ndual\tT-2\ncore\tT-2\nAMD\tT-2\nor\tO\nIntel\tT-3\nprocessor\tT-3\n.\tO\n\nIf\tO\nyou\tO\ncheck\tO\nyou\tO\nwill\tO\nfind\tO\nthe\tO\nsame\tT-0\nnotebook\tT-1\nwith\tO\nthe\tO\nabove\tO\nmissing\tO\nports\tO\nand\tO\na\tO\ndual\tO\ncore\tT-2\nAMD\tO\nor\tO\nIntel\tO\nprocessor\tB-aspectTerm\n.\tO\n\nThis\tO\nlaptop\tT-1\nis\tO\na\tO\ngreat\tT-0\nprice\tB-aspectTerm\nand\tO\nhas\tO\na\tO\nsleek\tT-2\nlook\tO\n.\tO\n\nThis\tO\nlaptop\tO\nis\tO\na\tO\ngreat\tO\nprice\tO\nand\tO\nhas\tO\na\tO\nsleek\tT-0\nlook\tB-aspectTerm\n.\tO\n\nI\tO\nespecially\tO\nlike\tO\nthe\tO\nkeyboard\tB-aspectTerm\nwhich\tO\nhas\tO\nchiclet\tO\ntype\tO\nkeys\tT-0\n.\tO\n\nI\tO\nespecially\tO\nlike\tO\nthe\tO\nkeyboard\tT-0\nwhich\tO\nhas\tO\nchiclet\tT-1\ntype\tT-1\nkeys\tB-aspectTerm\n.\tO\n\nSmall\tT-0\nscreen\tB-aspectTerm\nsomewhat\tT-1\nlimiting\tT-1\nbut\tO\ngreat\tT-2\nfor\tO\ntravel\tT-3\n.\tT-3\n\nRuns\tO\nHot\tO\nO\tO\nI\tO\nthought\tO\nwe\tO\nwere\tO\npaying\tT-0\nfor\tT-0\nquality\tB-aspectTerm\nin\tO\nour\tO\ndecision\tO\nto\tO\nbuy\tO\nan\tO\nApple\tO\nproduct\tO\n.\tO\n\nFor\tO\nthe\tO\nnot\tO\nso\tO\ngood\tO\n,\tO\nI\tO\ngot\tO\nthe\tO\nstock\tB-aspectTerm\nscreen\tI-aspectTerm\n-\tO\nwhich\tO\nis\tO\nVERY\tO\nglossy\tT-0\n.\tO\n\nThe\tT-0\ngray\tB-aspectTerm\ncolor\tI-aspectTerm\nwas\tT-1\na\tT-1\ngood\tT-1\nchoice\tT-1\n.\tT-2\n\nI\tO\nwould\tO\nlike\tT-0\nto\tO\nhave\tO\nvolume\tB-aspectTerm\nbuttons\tI-aspectTerm\nrather\tO\nthan\tO\nthe\tO\nadjustment\tT-1\nthat\tO\nis\tO\non\tO\nthe\tO\nfront\tO\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\na\tO\nAMD\tO\nSemprom\tO\nat\tO\n2.1\tO\nghz\tO\nis\tO\na\tO\nbummer\tO\nit\tO\ndoes\tO\nnot\tO\nhave\tO\nthe\tO\npower\tT-0\nfor\tO\nHD\tT-1\nor\tO\nheavy\tO\ncomputing\tO\n.\tO\n\nThe\tO\nprocessor\tO\na\tO\nAMD\tO\nSemprom\tT-0\nat\tO\n2.1\tO\nghz\tO\nis\tO\na\tO\nbummer\tO\nit\tO\ndoes\tO\nnot\tO\nhave\tO\nthe\tO\npower\tO\nfor\tO\nHD\tO\nor\tO\nheavy\tO\ncomputing\tB-aspectTerm\n.\tO\n\nI\tO\nbought\tT-0\na\tO\nprotector\tB-aspectTerm\nfor\tO\nmy\tO\nkey\tT-1\npad\tT-1\nand\tO\nit\tO\nworks\tO\ngreat\tO\n:)\tO\n\nI\tO\nbought\tO\na\tO\nprotector\tO\nfor\tO\nmy\tO\nkey\tB-aspectTerm\npad\tI-aspectTerm\nand\tT-1\nit\tO\nworks\tO\ngreat\tT-0\n:)\tT-0\n\nIt\tO\nseems\tO\nthey\tO\ncould\tO\nhave\tO\nupdated\tT-1\nXP\tB-aspectTerm\nand\tO\ndone\tO\nwithout\tO\ncreating\tO\nVista\tO\n.\tT-0\n\nIt\tO\nseems\tO\nthey\tO\ncould\tO\nhave\tO\nupdated\tT-1\nXP\tO\nand\tO\ndone\tT-0\nwithout\tO\ncreating\tO\nVista\tB-aspectTerm\n.\tO\n\nÂ\tO\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\n,\tT-1\nfast\tO\nand\tO\nhas\tO\ngreat\tO\ngraphics\tO\nfor\tO\nthe\tO\nmoney\tO\n.\tT-1\n\nÂ\tO\nIt\tO\nis\tO\neasy\tO\nto\tO\nuse\tO\n,\tO\nfast\tT-1\nand\tT-1\nhas\tO\ngreat\tO\ngraphics\tB-aspectTerm\nfor\tO\nthe\tO\nmoney\tO\n.\tT-0\n\nI\tO\nlike\tO\nhow\tO\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\nis\tO\nso\tO\nsimple\tT-0\nand\tO\neasy\tT-1\nto\tO\nuse\tO\n.\tO\n\nI\tO\nlike\tO\nhow\tO\nthe\tO\nMac\tO\nOS\tO\nis\tO\nso\tO\nsimple\tO\nand\tO\neasy\tT-0\nto\tT-0\nuse\tB-aspectTerm\n.\tO\n\nWhile\tO\nApple\tO\n's\tO\nsaving\tO\ngrace\tO\nis\tO\nthe\tO\nfact\tO\nthat\tO\nthey\tO\nat\tO\nleast\tO\nstand\tT-2\nbehind\tO\ntheir\tO\nproducts\tO\n,\tO\nand\tO\ntheir\tO\nsupport\tB-aspectTerm\nis\tO\ngreat\tO\n,\tO\nit\tO\nwould\tO\nbe\tO\nnice\tO\nif\tO\ntheir\tO\nproducts\tO\nwere\tO\nmore\tO\nreliable\tO\nto\tO\njustify\tT-0\nthe\tO\npremium\tT-1\n.\tO\n\nI\tO\nwas\tO\nready\tO\nto\tO\ntake\tO\nit\tO\nback\tO\nfor\tO\na\tO\nrefund\tT-1\n,\tO\nbut\tO\nthe\tO\nGeek\tB-aspectTerm\nSquad\tI-aspectTerm\ncamed\tT-2\nthrough\tO\nand\tO\npointed\tT-3\nme\tO\nin\tO\nthe\tO\nright\tO\ndirection\tO\nto\tO\nget\tO\nit\tO\nfixed\tO\n.\tT-0\n\nonly\tO\ngood\tT-0\nthing\tO\nis\tO\nthe\tO\ngraphics\tB-aspectTerm\nquality\tI-aspectTerm\n.\tO\n\nThe\tO\nother\tO\nlock\tT-0\n-\tT-0\nup\tT-0\nproblems\tT-0\nare\tO\nfrom\tO\na\tO\nmyriad\tO\nof\tO\ncauses\tO\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nbeing\tO\na\tO\ncorrupted\tO\nversion\tO\nof\tO\nAppleworks\tB-aspectTerm\nwhich\tO\ncan\tO\nrender\tT-1\nthe\tT-1\nbrowser\tT-1\nuseless\tT-1\n.\tO\n\nThe\tO\nother\tO\nlock\tT-0\n-\tT-0\nup\tT-0\nproblems\tO\nare\tO\nfrom\tO\na\tO\nmyriad\tO\nof\tO\ncauses\tO\n,\tO\nthe\tO\nmost\tO\ncommon\tO\nbeing\tO\na\tO\ncorrupted\tT-1\nversion\tO\nof\tO\nAppleworks\tO\nwhich\tO\ncan\tO\nrender\tO\nthe\tO\nbrowser\tB-aspectTerm\nuseless\tO\n.\tO\n\nThe\tO\npaint\tB-aspectTerm\nwears\tO\noff\tO\neasily\tT-0\ndue\tO\nto\tO\nthe\tO\nkeyboard\tT-1\nbeing\tO\nfarther\tO\nback\tO\nthan\tO\nusual\tO\n.\tO\n\nThe\tO\npaint\tT-1\nwears\tT-1\noff\tT-1\neasily\tO\ndue\tO\nto\tO\nthe\tO\nkeyboard\tB-aspectTerm\nbeing\tO\nfarther\tT-0\nback\tT-0\nthan\tO\nusual\tO\n.\tO\n\nI\tO\nhad\tO\npurchased\tO\nit\tO\nfrom\tO\na\tO\nmajor\tO\nelectronics\tT-0\nstore\tO\nand\tO\ntook\tO\nit\tO\nto\tO\ntheir\tO\nservice\tB-aspectTerm\ndepartment\tI-aspectTerm\nto\tO\nfind\tO\nout\tO\nwhat\tO\nthe\tO\nproblem\tT-1\nwas\tO\n.\tO\n\nThe\tO\nstore\tO\nhonored\tT-0\ntheir\tO\nwarrenty\tB-aspectTerm\nand\tO\nmade\tO\nthe\tO\ncomment\tO\nthat\tO\nthey\tO\ndo\tO\nn't\tO\neven\tO\nrecommend\tO\nthe\tO\nHP\tO\nbrand\tO\nbecause\tO\nof\tO\nthe\tO\nproblems\tT-1\nwith\tO\ntheir\tO\nwarrentys\tO\n.\tO\n\nThe\tO\nstore\tO\nhonored\tO\ntheir\tO\nwarrenty\tT-0\nand\tO\nmade\tO\nthe\tO\ncomment\tO\nthat\tO\nthey\tO\ndo\tO\nn't\tO\neven\tO\nrecommend\tT-3\nthe\tO\nHP\tT-1\nbrand\tO\nbecause\tO\nof\tO\nthe\tO\nproblems\tT-2\nwith\tO\ntheir\tO\nwarrentys\tB-aspectTerm\n.\tO\n\nI\tO\nalways\tO\nuse\tO\na\tO\nbackup\tT-0\nhard\tB-aspectTerm\ndisk\tI-aspectTerm\nto\tO\nstore\tO\nimportant\tO\nfiles\tO\nat\tO\nall\tO\ntimes\tO\n.\tO\n\nThey\tO\nsent\tO\nout\tO\nthe\tO\nbox\tO\nright\tO\naway\tO\nfor\tO\nme\tO\nto\tO\nsend\tO\nin\tO\nmy\tO\ncomputer\tO\n,\tO\nthey\tO\npaid\tT-1\npostage\tO\nand\tO\nwhatnot\tO\n,\tO\nbut\tO\nwhen\tO\nI\tO\ngot\tO\nmy\tO\ncomputer\tO\nback\tO\nit\tO\nstill\tO\nwas\tO\nn't\tO\nrunning\tB-aspectTerm\nright\tO\n,\tO\nand\tO\nnow\tO\nmy\tO\nCD\tO\ndrive\tO\nwas\tO\nn't\tO\nreading\tT-0\nanything\tO\n!\tO\n\nThey\tO\nsent\tO\nout\tO\nthe\tO\nbox\tO\nright\tO\naway\tO\nfor\tO\nme\tO\nto\tO\nsend\tO\nin\tO\nmy\tO\ncomputer\tT-0\n,\tO\nthey\tO\npaid\tO\npostage\tO\nand\tO\nwhatnot\tO\n,\tO\nbut\tO\nwhen\tO\nI\tO\ngot\tO\nmy\tO\ncomputer\tT-1\nback\tO\nit\tO\nstill\tO\nwas\tO\nn't\tO\nrunning\tO\nright\tO\n,\tO\nand\tO\nnow\tO\nmy\tO\nCD\tB-aspectTerm\ndrive\tI-aspectTerm\nwas\tO\nn't\tO\nreading\tT-2\nanything\tO\n!\tO\n\nBut\tT-0\nthe\tT-0\nscreen\tB-aspectTerm\nsize\tI-aspectTerm\nis\tO\nnot\tO\nthat\tO\nbad\tO\nfor\tO\nemail\tO\nand\tO\nweb\tO\nbrowsing\tT-1\n.\tO\n\nBut\tO\nthe\tO\nscreen\tT-0\nsize\tT-1\nis\tO\nnot\tO\nthat\tO\nbad\tO\nfor\tO\nemail\tT-2\nand\tO\nweb\tB-aspectTerm\nbrowsing\tI-aspectTerm\n.\tO\n\nOnce\tO\nI\tO\nremoved\tO\nall\tO\nthe\tO\nsoftware\tB-aspectTerm\nthe\tO\nlaptop\tO\nloads\tT-1\nin\tO\n15\tO\n-\tO\n20\tO\nseconds\tT-0\n.\tO\n\nOnce\tO\nI\tO\nremoved\tT-0\nall\tO\nthe\tO\nsoftware\tO\nthe\tO\nlaptop\tO\nloads\tB-aspectTerm\nin\tO\n15\tO\n-\tO\n20\tO\nseconds\tO\n.\tO\n\nOn\tO\nmy\tO\nPowerBook\tO\nG4\tO\nI\tO\nwould\tO\nnever\tT-0\nuse\tT-0\nthe\tO\ntrackpad\tB-aspectTerm\nI\tO\nwould\tO\nuse\tO\nan\tO\nexternal\tO\nmouse\tT-1\nbecause\tO\nI\tO\ndid\tO\nn't\tO\nlike\tO\nthe\tO\ntrackpad\tT-2\n.\tO\n\nOn\tO\nmy\tO\nPowerBook\tO\nG4\tO\nI\tO\nwould\tO\nnever\tO\nuse\tO\nthe\tO\ntrackpad\tT-1\nI\tO\nwould\tT-0\nuse\tO\nan\tO\nexternal\tB-aspectTerm\nmouse\tI-aspectTerm\nbecause\tO\nI\tO\ndid\tO\nn't\tO\nlike\tO\nthe\tO\ntrackpad\tT-2\n.\tO\n\nOn\tO\nmy\tO\nPowerBook\tO\nG4\tO\nI\tO\nwould\tO\nnever\tO\nuse\tO\nthe\tO\ntrackpad\tT-1\nI\tO\nwould\tT-0\nuse\tO\nan\tO\nexternal\tO\nmouse\tT-2\nbecause\tO\nI\tO\ndid\tO\nn't\tO\nlike\tO\nthe\tO\ntrackpad\tB-aspectTerm\n.\tO\n\nThis\tO\ncomputer\tO\ndoes\tO\nn't\tO\ndo\tO\nthat\tO\nwell\tO\nwith\tO\ncertain\tO\ngames\tB-aspectTerm\nit\tO\nca\tO\nn't\tO\nplay\tT-1\nsome\tO\nand\tO\nit\tO\nbecomes\tO\ntoo\tO\nhot\tO\nwhile\tO\nplaying\tT-0\ngames\tO\n.\tO\n\nObviously\tO\none\tO\nof\tO\nthe\tO\nmost\tO\nimportant\tT-0\nfeatures\tB-aspectTerm\nof\tO\nany\tO\ncomputer\tO\nis\tO\nthe\tO\n\"\tO\nhuman\tT-1\ninterface\tT-1\n.\tO\n\nYeah\tO\n,\tO\nof\tO\ncourse\tO\nsmarty\tO\npants\tO\n\"\tO\nfix\tO\nit\tO\nnow\")Software\tT-1\n-\tO\nCompared\tO\nto\tO\nthe\tO\nearly\tO\n2011\tO\nedition\tO\nI\tO\ndid\tO\nsee\tO\ninbuilt\tB-aspectTerm\napplications\tI-aspectTerm\ncrashing\tT-0\nand\tO\nit\tO\nprompted\tO\nme\tO\nto\tO\nsend\tO\nthe\tO\nreport\tO\nto\tO\nApple\tO\n(\tO\nwhich\tO\nI\tO\npromptly\tO\ndid\tO\n)\tO\n.\tT-1\n\nThe\tO\nbody\tB-aspectTerm\nis\tO\na\tO\nbit\tO\ncheaply\tT-0\nmade\tT-0\nso\tO\nit\tO\nwill\tO\nbe\tO\ninteresting\tO\nto\tO\nsee\tO\nhow\tO\nlong\tO\nit\tO\nholds\tO\nup\tO\n.\tO\n\nThe\tO\ni5\tB-aspectTerm\nblows\tO\nmy\tO\ndesktop\tT-0\nout\tO\nof\tO\nthe\tO\nwater\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\nrendering\tT-1\nvideos\tT-1\n.\tO\n\nWith\tO\na\tO\nmac\tO\nyou\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tT-1\nabout\tO\nantivirus\tB-aspectTerm\nsoftware\tI-aspectTerm\nor\tO\nfirewall\tT-0\n,\tO\nit\tO\n's\tO\nso\tO\nwonderful\tO\n.\tO\n\nWith\tO\na\tO\nmac\tO\nyou\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nworry\tT-1\nabout\tO\nantivirus\tT-0\nsoftware\tO\nor\tO\nfirewall\tB-aspectTerm\n,\tO\nit\tO\n's\tO\nso\tO\nwonderful\tO\n.\tO\n\nAm\tO\nvery\tO\nglad\tO\nI\tO\nbought\tT-1\nit\tO\n,\tO\ngreat\tO\nnetbook\tT-2\n,\tO\nlow\tT-0\nprice\tB-aspectTerm\n.\tO\n\nThe\tO\nApple\tB-aspectTerm\nteam\tI-aspectTerm\nalso\tO\nassists\tO\nyou\tO\nvery\tO\nnicely\tO\nwhen\tO\nchoosing\tO\nwhich\tO\ncomputer\tT-0\nis\tO\nright\tO\nfor\tO\nyou\tO\n:)\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tT-1\nis\tO\nVista\tB-aspectTerm\n,\tO\nyet\tO\nI\tO\nknow\tO\nVista\tT-0\nis\tO\nn't\tO\nthe\tO\nentire\tO\nissue\tO\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tO\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tO\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tO\nsystem\tO\n)\tO\n.\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tT-2\nis\tO\nVista\tT-3\n,\tO\nyet\tT-0\nI\tT-0\nknow\tT-0\nVista\tB-aspectTerm\nis\tT-1\nn't\tT-1\nthe\tT-1\nentire\tT-1\nissue\tT-1\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tT-4\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tO\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tO\nsystem\tO\n)\tO\n.\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tT-2\nis\tO\nVista\tO\n,\tO\nyet\tO\nI\tO\nknow\tO\nVista\tO\nis\tO\nn't\tO\nthe\tO\nentire\tO\nissue\tO\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tT-0\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tB-aspectTerm\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tT-1\nsystem\tT-1\n)\tO\n.\tO\n\nI\tO\nthink\tO\npart\tO\nof\tO\nthe\tO\nproblem\tO\nwith\tO\nthis\tO\ncomputer\tT-0\nis\tO\nVista\tT-1\n,\tO\nyet\tO\nI\tO\nknow\tO\nVista\tT-2\nis\tO\nn't\tO\nthe\tO\nentire\tT-4\nissue\tT-4\nbecause\tO\nmy\tO\nlatest\tO\npurchase\tO\nwas\tO\nmy\tO\nAcer\tO\nand\tO\nit\tO\nalso\tO\nhas\tO\nVista\tT-3\n(\tO\nI\tO\nshould\tO\nhave\tO\nwaited\tO\nthe\tO\nfew\tO\nmonths\tO\nto\tO\nget\tO\nthe\tO\nnext\tO\noperating\tB-aspectTerm\nsystem\tI-aspectTerm\n)\tO\n.\tO\n\nThe\tO\nvideo\tB-aspectTerm\nchat\tI-aspectTerm\nis\tO\nthe\tO\nonly\tO\nthing\tO\nthat\tO\nis\tO\niffy\tO\nabout\tO\nit\tO\nbut\tO\ni\tO\nm\tO\nsure\tO\nonce\tO\nthey\tO\nunpdate\tO\nthe\tO\nnext\tO\nversion\tT-0\non\tO\nthe\tO\nmacbook\tO\nbook\tO\nthe\tO\nquality\tO\nof\tO\nit\tO\nwill\tO\nbe\tO\nbetter\tO\n.\tO\n\nThe\tO\nvideo\tT-0\nchat\tT-0\nis\tO\nthe\tO\nonly\tO\nthing\tO\nthat\tO\nis\tO\niffy\tT-2\nabout\tO\nit\tO\nbut\tO\ni\tO\nm\tO\nsure\tO\nonce\tO\nthey\tO\nunpdate\tO\nthe\tO\nnext\tO\nversion\tT-1\non\tO\nthe\tO\nmacbook\tO\nbook\tO\nthe\tO\nquality\tB-aspectTerm\nof\tO\nit\tO\nwill\tO\nbe\tO\nbetter\tO\n.\tO\n\nThat\tO\nwhole\tO\nexperience\tO\nwas\tO\njust\tO\nridiculous\tO\nwe\tO\nsent\tO\nit\tO\nin\tO\nand\tO\nafter\tO\nthey\tO\ntold\tO\nus\tO\nthat\tO\nwe\tO\nhad\tO\nto\tO\npay\tO\n$\tO\n175\tO\nto\tO\nfix\tO\nit\tO\nwe\tO\nwere\tO\nlike\tO\nwe\tO\nwill\tO\njust\tO\nby\tO\na\tO\nportable\tT-0\nmouse\tB-aspectTerm\nwhich\tO\nwould\tO\nbe\tO\nway\tO\ncheaper\tO\nbut\tO\nthey\tO\nrefused\tT-1\nto\tO\nsend\tO\nthe\tO\nlaptop\tO\nback\tO\nuntil\tO\nwe\tO\npaid\tO\nthe\tO\n$\tO\n175\tO\nand\tO\nit\tO\nwas\tO\nfixed\tO\n.\tO\n\nFan\tB-aspectTerm\nvents\tT-1\nto\tO\nthe\tO\nside\tO\n,\tO\nso\tO\nno\tT-2\ncooling\tT-2\npad\tT-2\nneeded\tT-2\n,\tO\ngreat\tT-3\nfeature\tT-3\n!\tO\n\ni\tO\nuse\tO\nmy\tO\nmac\tO\nall\tO\nthe\tO\ntime\tO\n,\tO\ni\tT-0\nlove\tT-0\nthe\tT-0\nsoftware\tB-aspectTerm\n,\tO\nthe\tO\nway\tO\nit\tO\ntakes\tO\na\tO\nshort\tO\ntime\tO\nto\tT-1\nload\tT-1\nthings\tT-1\n,\tO\nhow\tO\neasy\tO\nit\tO\nis\tO\nto\tO\nuse\tO\nand\tO\nmost\tO\nof\tO\nall\tO\nhow\tO\nyou\tO\ndo\tT-2\nn't\tT-2\nhave\tT-2\nto\tT-2\nworry\tT-2\nabout\tT-2\nviruses\tT-2\n.\tO\n\nWasted\tO\nme\tO\nat\tO\nleast\tO\n8\tO\nhours\tT-0\nof\tO\ninstallation\tB-aspectTerm\ntime\tI-aspectTerm\n.\tO\n\nIt\tO\nhas\tO\nfar\tO\nexceeded\tO\nmy\tO\nexpectations\tO\nfor\tO\npower\tB-aspectTerm\n,\tO\nstorage\tO\n,\tO\nand\tO\nabilitiy\tO\n.\tT-0\n\nIt\tO\nhas\tO\nfar\tO\nexceeded\tO\nmy\tO\nexpectations\tO\nfor\tO\npower\tT-0\n,\tO\nstorage\tB-aspectTerm\n,\tO\nand\tO\nabilitiy\tT-1\n.\tO\n\nIt\tO\nhas\tO\nfar\tO\nexceeded\tT-3\nmy\tO\nexpectations\tT-0\nfor\tO\npower\tT-1\n,\tO\nstorage\tT-2\n,\tO\nand\tO\nabilitiy\tB-aspectTerm\n.\tT-4\n\nA\tO\ngreat\tO\nfeature\tB-aspectTerm\nis\tO\nthe\tO\nspotlight\tT-0\nsearch\tT-1\n:\tO\none\tO\ncan\tO\nsearch\tO\nfor\tO\ndocuments\tT-2\nby\tO\nsimply\tO\ntyping\tO\na\tO\nkeyword\tO\n,\tO\nrather\tO\nthan\tO\nparsing\tO\ntens\tO\nof\tO\nfile\tO\nfolders\tO\nfor\tO\na\tO\ndocument\tO\n.\tO\n\nA\tO\ngreat\tT-0\nfeature\tT-1\nis\tT-1\nthe\tT-1\nspotlight\tB-aspectTerm\nsearch\tI-aspectTerm\n:\tO\none\tO\ncan\tO\nsearch\tT-2\nfor\tT-2\ndocuments\tT-2\nby\tO\nsimply\tO\ntyping\tO\na\tO\nkeyword\tT-3\n,\tO\nrather\tO\nthan\tO\nparsing\tO\ntens\tO\nof\tO\nfile\tO\nfolders\tO\nfor\tO\na\tO\ndocument\tO\n.\tO\n\nMy\tT-0\nwireless\tB-aspectTerm\nsystem\tI-aspectTerm\nwould\tO\nnot\tO\nrecognize\tO\nWindows\tT-1\n7\tT-1\nand\tO\nI\tO\ncould\tO\nn't\tO\nget\tO\nonline\tT-2\nto\tO\nfind\tO\nout\tO\nwhy\tO\n.\tO\n\nMy\tO\nwireless\tT-0\nsystem\tT-1\nwould\tO\nnot\tO\nrecognize\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nand\tO\nI\tO\ncould\tO\nn't\tO\nget\tO\nonline\tO\nto\tO\nfind\tO\nout\tO\nwhy\tO\n.\tO\n\nSuffice\tO\nit\tO\nto\tO\nsay\tO\n,\tO\nmy\tO\nMacBook\tO\nPro\tO\nkeeps\tO\nme\tO\ngoing\tO\nwith\tO\nits\tO\nlong\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nand\tO\nblazing\tT-0\nspeed\tO\n.\tO\n\nSuffice\tO\nit\tO\nto\tO\nsay\tO\n,\tO\nmy\tO\nMacBook\tT-1\nPro\tT-1\nkeeps\tO\nme\tO\ngoing\tO\nwith\tO\nits\tO\nlong\tO\nbattery\tT-2\nlife\tT-2\nand\tO\nblazing\tT-0\nspeed\tB-aspectTerm\n.\tO\n\nThe\tO\nOS\tB-aspectTerm\nis\tO\nalso\tO\nvery\tO\nuser\tT-1\nfriendly\tT-1\n,\tO\neven\tO\nfor\tO\nthose\tO\nthat\tO\nswitch\tO\nfrom\tO\na\tO\nPC\tT-3\n,\tO\nwith\tO\na\tO\nlittle\tO\npractice\tO\nyou\tO\ncan\tO\ntake\tO\nfull\tO\nadvantage\tO\nof\tO\nthis\tO\nOS\tT-2\n!\tO\n\nThe\tO\nOS\tT-0\nis\tO\nalso\tO\nvery\tO\nuser\tO\nfriendly\tO\n,\tO\neven\tO\nfor\tO\nthose\tO\nthat\tO\nswitch\tT-1\nfrom\tO\na\tO\nPC\tT-2\n,\tO\nwith\tO\na\tO\nlittle\tO\npractice\tO\nyou\tO\ncan\tO\ntake\tO\nfull\tO\nadvantage\tO\nof\tO\nthis\tO\nOS\tB-aspectTerm\n!\tO\n\niTunes\tB-aspectTerm\nis\tO\na\tO\nhandy\tO\nmusic\tO\n-\tO\nmanagement\tT-1\nprogram\tT-1\n,\tO\nand\tO\nit\tO\nis\tO\nessential\tO\nfor\tO\nanyone\tO\nwith\tO\nan\tO\niPod\tT-2\n.\tO\n\niTunes\tO\nis\tO\na\tO\nhandy\tO\nmusic\tO\n-\tO\nmanagement\tT-0\nprogram\tB-aspectTerm\n,\tO\nand\tO\nit\tO\nis\tO\nessential\tT-1\nfor\tO\nanyone\tO\nwith\tO\nan\tO\niPod\tO\n.\tO\n\nMac\tO\nis\tO\nnot\tO\nmade\tT-0\nfor\tO\ngaming\tB-aspectTerm\n.\tO\n\nWell\tO\nI\tO\nspilled\tT-0\nsomething\tO\non\tO\nit\tO\nand\tO\nthey\tO\nreplaced\tO\nit\tO\nwith\tO\nthis\tO\nmodel\tT-2\n,\tO\nwhich\tO\ngets\tO\nhot\tT-1\nand\tO\nthe\tO\nbattery\tB-aspectTerm\ndoes\tO\nn't\tO\nmake\tO\nit\tO\nthrough\tO\n1\tO\nDVD\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nto\tO\ncall\tO\nApple\tB-aspectTerm\nsupport\tI-aspectTerm\nto\tO\nset\tO\nup\tO\nmy\tO\nnew\tO\nprinter\tT-3\nand\tO\nhave\tO\nhad\tO\nwonderful\tT-1\nexperiences\tT-2\nwith\tO\nhelpful\tT-0\n,\tO\nenglish\tO\nspeaking\tO\n(\tO\nfrom\tO\nVancouver\tO\n)\tO\ntechs\tT-4\nthat\tO\nwalked\tO\nme\tO\nthrough\tO\nthe\tO\nprocesses\tO\nto\tO\nhelp\tO\nme\tO\n.\tO\n\nI\tO\n've\tO\nhad\tO\nto\tO\ncall\tO\nApple\tT-0\nsupport\tO\nto\tO\nset\tO\nup\tO\nmy\tO\nnew\tT-4\nprinter\tT-1\nand\tO\nhave\tO\nhad\tO\nwonderful\tO\nexperiences\tO\nwith\tO\nhelpful\tO\n,\tO\nenglish\tT-3\nspeaking\tT-3\n(\tO\nfrom\tO\nVancouver\tO\n)\tO\ntechs\tB-aspectTerm\nthat\tO\nwalked\tO\nme\tO\nthrough\tO\nthe\tO\nprocesses\tO\nto\tO\nhelp\tT-2\nme\tO\n.\tO\n\nBut\tO\nSony\tO\nsaid\tO\nwe\tO\ncould\tO\nsend\tT-0\nit\tT-0\nback\tT-0\nand\tO\nbe\tO\ncharged\tT-1\nfor\tO\nadding\tB-aspectTerm\nthe\tI-aspectTerm\nbluetooth\tI-aspectTerm\nan\tO\nadditional\tO\nseventy\tO\nsomething\tO\ndollars\tO\n.\tO\n\nI\tO\nneed\tO\ngraphic\tB-aspectTerm\npower\tI-aspectTerm\nto\tO\nrun\tO\nmy\tO\nAdobe\tO\nCreative\tT-0\napps\tT-1\nefficiently\tO\n.\tO\n\nI\tO\nneed\tO\ngraphic\tT-2\npower\tT-2\nto\tO\nrun\tO\nmy\tO\nAdobe\tB-aspectTerm\nCreative\tI-aspectTerm\napps\tI-aspectTerm\nefficiently\tT-1\n.\tO\n\nthe\tO\nprograms\tB-aspectTerm\nare\tO\nesay\tO\nto\tO\nuse\tO\nand\tO\nare\tO\nquick\tT-2\nto\tO\nprocess\tT-1\nthis\tO\ncomputer\tO\nworks\tO\nlike\tO\na\tO\ncharm\tT-0\n.\tO\n\nthe\tO\nprograms\tT-0\nare\tO\nesay\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nare\tO\nquick\tO\nto\tO\nprocess\tT-1\nthis\tO\ncomputer\tO\nworks\tO\nlike\tO\na\tO\ncharm\tO\n.\tO\n\nThe\tO\nmaterials\tB-aspectTerm\nthat\tO\ncame\tT-0\nwith\tT-0\nthe\tO\ncomputer\tT-1\ndid\tO\nnot\tO\ninclude\tT-2\nthe\tO\nright\tO\n#\tO\nanywhere\tO\n.\tO\n\nTech\tB-aspectTerm\nsupport\tI-aspectTerm\ntells\tO\nme\tO\nthe\tO\nlatter\tO\nproblem\tT-0\nis\tO\na\tO\npower\tO\nsupply\tO\nproblem\tT-1\nand\tO\nhave\tO\noffered\tO\nto\tO\nfix\tT-2\nit\tO\nif\tO\nit\tO\nhappens\tO\nagain\tO\n.\tO\n\nTech\tO\nsupport\tO\ntells\tO\nme\tO\nthe\tO\nlatter\tO\nproblem\tT-0\nis\tO\na\tO\npower\tB-aspectTerm\nsupply\tI-aspectTerm\nproblem\tO\nand\tO\nhave\tO\noffered\tO\nto\tO\nfix\tT-1\nit\tT-1\nif\tO\nit\tO\nhappens\tO\nagain\tO\n.\tO\n\nHOW\tO\nDOES\tO\nTHE\tO\nPOWER\tB-aspectTerm\nSUPPLY\tI-aspectTerm\nNOT\tO\nWORK\tO\n!\tO\n!\tO\n!\tT-0\n\nSells\tO\nfor\tO\nthe\tO\nsame\tO\nas\tO\na\tO\nnetbook\tO\nwithout\tT-0\nsacrificing\tT-1\nsize\tB-aspectTerm\n.\tO\n\nÂ\tO\nupon\tO\ngiving\tO\nthem\tO\nthe\tO\nserial\tO\nnumber\tT-0\nthe\tT-1\nfirst\tO\nthing\tO\nI\tO\nwas\tO\ntold\tO\n,\tO\nwas\tO\nthat\tO\nit\tO\nwas\tO\nout\tO\nof\tO\nwarranty\tB-aspectTerm\nand\tO\nI\tO\ncould\tO\npay\tO\nto\tO\nhave\tO\nit\tO\nrepaired\tO\n.\tT-1\n\nWindows\tB-aspectTerm\nXP\tI-aspectTerm\nSP2\tI-aspectTerm\ncaused\tO\nmany\tO\nproblems\tT-1\non\tO\nthe\tO\ncomputer\tT-0\n,\tO\nso\tO\nI\tO\nhad\tO\nto\tO\nremove\tO\nit\tO\n.\tO\n\nI\tO\nreloaded\tT-1\nwith\tO\nWindows\tO\n7\tO\nUltimate\tO\n,\tO\nand\tT-0\nthe\tT-0\nBluetooth\tB-aspectTerm\nand\tO\nFingerprint\tT-2\nreader\tT-2\n(\tO\nsoftware\tO\n)\tO\nwould\tO\nnot\tO\nload\tO\n.\tO\n\nI\tO\nreloaded\tT-0\nwith\tO\nWindows\tO\n7\tO\nUltimate\tO\n,\tO\nand\tO\nthe\tO\nBluetooth\tO\nand\tO\nFingerprint\tB-aspectTerm\nreader\tI-aspectTerm\n(\tO\nsoftware\tO\n)\tO\nwould\tO\nnot\tO\nload\tO\n.\tO\n\nI\tO\nreloaded\tT-1\nwith\tO\nWindows\tO\n7\tO\nUltimate\tO\n,\tO\nand\tT-0\nthe\tO\nBluetooth\tT-2\nand\tO\nFingerprint\tT-3\nreader\tO\n(\tO\nsoftware\tB-aspectTerm\n)\tO\nwould\tO\nnot\tO\nload\tO\n.\tO\n\nNone\tO\nof\tO\nthe\tO\ntechs\tB-aspectTerm\nat\tI-aspectTerm\nHP\tI-aspectTerm\nknew\tO\nwhat\tO\nthey\tT-0\nwere\tO\ndoing\tT-1\n.\tO\n\nthis\tO\nis\tO\nmy\tO\nsecond\tO\none\tO\nand\tO\nthe\tO\nsame\tO\nproblem\tO\n,\tO\nbad\tO\nvideo\tB-aspectTerm\ncard\tI-aspectTerm\nO\tO\nunreliable\tT-1\noverall\tO\n,\tO\nthis\tO\nwill\tO\nbe\tO\nmy\tO\nsecond\tT-0\ntime\tO\nreturning\tO\nthis\tO\nlaptop\tO\nback\tO\nto\tO\nbest\tO\nbuy\tO\n.\tO\n\nWith\tO\nawesome\tO\ngraphics\tT-1\nand\tO\nassuring\tT-0\nsecurity\tB-aspectTerm\n,\tO\nit\tO\n's\tO\nperfect\tO\n!\tO\n\nLaptop\tO\nwas\tO\nin\tO\nnew\tO\ncondition\tO\nand\tO\noperational\tT-2\n,\tO\nbut\tT-0\nfor\tT-0\nthe\tT-0\naudio\tB-aspectTerm\nproblem\tO\nwhen\tO\n1st\tO\nsent\tO\nfor\tO\nrepair\tO\n.\tT-1\n\nI\tO\nwas\tO\ndisappointed\tO\nwhen\tO\nI\tO\nrealized\tO\nthat\tO\nthe\tO\nkeyboard\tB-aspectTerm\ndoes\tO\nn't\tO\nlight\tO\nup\tO\non\tO\nthis\tO\nmodel\tT-0\n.\tT-1\n\nIt\tO\nruns\tB-aspectTerm\nperfectly\tT-0\n.\tO\n\nThe\tO\nlaptop\tO\nwas\tO\nvery\tT-0\neasy\tT-1\nto\tT-1\nset\tB-aspectTerm\nup\tI-aspectTerm\n.\tO\n\nÂ\tO\nSometimes\tO\nthe\tT-0\nscreen\tB-aspectTerm\neven\tO\ngoes\tO\nblack\tO\non\tO\nthis\tO\ncomputer\tO\n.\tT-1\n\nI\tT-0\nrecommend\tT-0\nfor\tT-0\nword\tB-aspectTerm\nprocessing\tI-aspectTerm\nand\tO\ninternet\tT-1\nusers\tT-1\n.\tO\n\nSince\tT-0\nI\tT-0\n've\tT-0\nhad\tT-0\nthis\tT-0\ncomputer\tT-0\nI\tT-0\n've\tT-0\nonly\tT-0\nused\tT-0\nthe\tT-0\ntrackpad\tB-aspectTerm\nbecause\tO\nit\tT-1\nis\tT-1\nso\tT-1\nnice\tT-1\nand\tT-1\nsmooth\tT-1\n.\tO\n\nA\tT-0\nlonger\tT-0\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwould\tO\nhave\tO\nbeen\tO\ngreat\tO\n-\tO\nbut\tO\nit\tO\nmeets\tO\nit\tO\n's\tO\nspec\tO\nquite\tO\neasily\tT-1\n.\tO\n\nA\tO\nlonger\tT-1\nbattery\tT-1\nlife\tT-1\nwould\tO\nhave\tO\nbeen\tO\ngreat\tO\n-\tO\nbut\tO\nit\tO\nmeets\tO\nit\tO\n's\tO\nspec\tB-aspectTerm\nquite\tO\neasily\tO\n.\tT-0\n\nWho\tO\ncould\tO\nn't\tO\nlove\tO\na\tO\nDVD\tB-aspectTerm\nburner\tI-aspectTerm\n,\tO\n80-gigabyte\tT-1\nHD\tO\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tO\nchip\tO\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tT-0\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tO\nand\tO\nToshiba\tO\nmachines\tO\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tO\n-\tO\nquality\tO\ncomponents\tO\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tT-1\n\nWho\tO\ncould\tO\nn't\tO\nlove\tO\na\tO\nDVD\tO\nburner\tO\n,\tO\n80-gigabyte\tT-0\nHD\tB-aspectTerm\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tO\nchip\tO\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tO\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tO\nand\tO\nToshiba\tO\nmachines\tO\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tO\n-\tO\nquality\tO\ncomponents\tO\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tO\n\nWho\tO\ncould\tT-0\nn't\tO\nlove\tO\na\tO\nDVD\tT-1\nburner\tT-1\n,\tO\n80-gigabyte\tT-2\nHD\tT-2\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tB-aspectTerm\nchip\tI-aspectTerm\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tO\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tT-3\nand\tO\nToshiba\tT-4\nmachines\tT-5\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tO\n-\tO\nquality\tO\ncomponents\tO\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tO\n\nWho\tO\ncould\tO\nn't\tO\nlove\tO\na\tO\nDVD\tO\nburner\tO\n,\tO\n80-gigabyte\tO\nHD\tO\n,\tO\nand\tO\nfairly\tO\nnew\tO\ngraphics\tT-0\nchip\tO\n?\tO\nAs\tO\nI\tO\nsoon\tO\ndiscovered\tO\n,\tO\nthough\tO\n,\tO\nthere\tO\nis\tO\na\tO\nreason\tO\nfor\tO\nwhich\tO\nsimilarly\tO\n-\tO\nconfigured\tO\nSony\tO\nand\tO\nToshiba\tO\nmachines\tO\ncost\tO\nmore\tO\n:\tO\nthey\tO\nuse\tO\nhigher\tT-1\n-\tT-1\nquality\tT-1\ncomponents\tB-aspectTerm\nthat\tO\nare\tO\nfaster\tO\n,\tO\nbetter\tO\n-\tO\nconfigured\tO\n,\tO\nand\tO\nend\tO\nup\tO\nlasting\tO\na\tO\nlot\tO\nlonger\tO\n.\tO\n\nIts\tO\nfast\tT-0\nand\tO\nanother\tO\nthing\tT-2\nI\tO\nlike\tO\nis\tO\nthat\tO\nit\tO\nhas\tO\nthree\tT-1\nUSB\tB-aspectTerm\nports\tI-aspectTerm\n.\tO\n\nThe\tO\nsalesman\tT-1\ntalked\tO\nus\tO\ninto\tO\nthis\tO\ncomputer\tO\naway\tO\nfrom\tO\nanother\tO\nwe\tO\nwere\tO\nlooking\tO\nat\tO\nand\tO\nwe\tT-0\nhave\tT-0\nhad\tT-0\nnothing\tT-0\nbut\tT-0\nproblems\tT-0\nwith\tT-0\nsoftware\tB-aspectTerm\nproblems\tO\nand\tO\njust\tO\nnot\tO\nhappy\tO\nwith\tO\nit\tO\n.\tO\n\nThat\tO\nsystem\tB-aspectTerm\nis\tO\nfixed\tT-0\n.\tO\n\nLike\tT-0\nthe\tO\nprice\tB-aspectTerm\nand\tO\noperation\tO\n.\tO\n\nLike\tO\nthe\tO\nprice\tO\nand\tO\noperation\tB-aspectTerm\n.\tT-0\n\nThe\tO\nbrand\tB-aspectTerm\nis\tO\ntarnished\tO\nin\tO\nmy\tO\nheart\tT-0\n.\tO\n\nThis\tO\nis\tO\nlikely\tO\ndue\tO\nto\tO\npoor\tO\ngrounding\tT-1\nand\tO\nisolation\tT-2\nbetween\tT-0\nthe\tO\ncomponents\tB-aspectTerm\n,\tO\nand\tO\nI\tO\n'm\tO\nhoping\tO\nthat\tO\nit\tO\ncan\tO\nbe\tO\nfixed\tO\nwith\tO\na\tO\nground\tT-3\nloop\tT-3\nisolator\tT-3\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tO\nbetter\tO\nproduct\tO\nquality\tO\nfor\tO\nthis\tO\nprice\tO\nrange\tO\n.\tO\n\nThis\tO\nis\tO\nlikely\tO\ndue\tO\nto\tO\npoor\tO\ngrounding\tT-2\nand\tT-2\nisolation\tT-2\nbetween\tO\nthe\tO\ncomponents\tT-3\n,\tO\nand\tT-0\nI\tT-0\n'm\tT-0\nhoping\tT-0\nthat\tT-0\nit\tT-0\ncan\tT-0\nbe\tT-0\nfixed\tT-0\nwith\tT-0\na\tT-0\nground\tB-aspectTerm\nloop\tI-aspectTerm\nisolator\tI-aspectTerm\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tO\nbetter\tO\nproduct\tO\nquality\tO\nfor\tO\nthis\tO\nprice\tO\nrange\tT-1\n.\tO\n\nThis\tO\nis\tO\nlikely\tT-2\ndue\tO\nto\tO\npoor\tO\ngrounding\tO\nand\tO\nisolation\tO\nbetween\tO\nthe\tO\ncomponents\tT-0\n,\tO\nand\tO\nI\tO\n'm\tO\nhoping\tO\nthat\tO\nit\tO\ncan\tO\nbe\tO\nfixed\tO\nwith\tO\na\tO\nground\tT-1\nloop\tT-1\nisolator\tT-1\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tT-3\nbetter\tO\nproduct\tO\nquality\tB-aspectTerm\nfor\tO\nthis\tO\nprice\tO\nrange\tO\n.\tO\n\nThis\tO\nis\tO\nlikely\tO\ndue\tO\nto\tO\npoor\tO\ngrounding\tT-0\nand\tO\nisolation\tT-1\nbetween\tO\nthe\tO\ncomponents\tO\n,\tO\nand\tO\nI\tO\n'm\tO\nhoping\tO\nthat\tO\nit\tO\ncan\tO\nbe\tO\nfixed\tO\nwith\tO\na\tO\nground\tO\nloop\tO\nisolator\tT-2\n,\tO\nbut\tO\nI\tO\nstill\tO\nexpected\tO\nbetter\tO\nproduct\tO\nquality\tO\nfor\tO\nthis\tO\nprice\tB-aspectTerm\nrange\tI-aspectTerm\n.\tO\n\nI\tO\n'\tO\nhave\tO\nhad\tO\nit\tO\nfor\tO\nabout\tO\na\tO\n1\tO\n1/2\tO\nand\tO\nyes\tO\nI\tO\nhave\tO\nhad\tO\nan\tO\nissue\tO\nwith\tO\nit\tO\none\tO\nmonth\tO\nout\tT-0\nof\tT-0\nwarranty\tB-aspectTerm\n.\tT-1\n\nOnce\tO\nopen\tT-0\n,\tO\nthe\tO\nleading\tB-aspectTerm\nedge\tI-aspectTerm\nis\tO\nrazor\tT-1\nsharp\tO\n.\tO\n\nLoaded\tT-0\nwith\tO\nbloatware\tB-aspectTerm\n.\tO\n\nMaximum\tB-aspectTerm\nsound\tI-aspectTerm\nis\tO\nn't\tO\nnearly\tO\nas\tO\nloud\tT-0\nas\tO\nit\tO\nshould\tO\nbe\tO\n.\tT-1\n\nI\tO\nloaded\tT-0\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nvia\tO\nBootcamp\tO\nand\tO\nit\tO\nworks\tT-1\nflawlessly\tT-2\n!\tO\n\nI\tO\nloaded\tT-0\nwindows\tT-2\n7\tO\nvia\tO\nBootcamp\tB-aspectTerm\nand\tO\nit\tO\nworks\tT-1\nflawlessly\tO\n!\tO\n\nGreat\tO\nLaptop\tO\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n,\tO\nworks\tT-0\nwell\tT-0\nwith\tO\naction\tO\npack\tO\ngames\tO\n.\tO\n\nGreat\tO\nLaptop\tT-1\nfor\tO\nthe\tO\nprice\tT-2\n,\tO\nworks\tB-aspectTerm\nwell\tO\nwith\tO\naction\tO\npack\tO\ngames\tT-3\n.\tT-0\n\nGreat\tT-2\nLaptop\tO\nfor\tO\nthe\tO\nprice\tT-1\n,\tO\nworks\tT-0\nwell\tT-0\nwith\tT-0\naction\tB-aspectTerm\npack\tI-aspectTerm\ngames\tI-aspectTerm\n.\tO\n\nAlthough\tO\nthe\tO\nprice\tB-aspectTerm\nis\tO\nhigher\tT-2\nthen\tO\nDell\tO\nlaptops\tO\n,\tO\nthe\tO\nMacbooks\tT-1\nare\tO\nworth\tO\nthe\tO\ndough\tT-0\n.\tO\n\nI\tO\nwould\tO\nnot\tO\nrecommend\tT-0\nthis\tO\nto\tO\nanyone\tO\nwanting\tO\na\tO\nnotebook\tT-1\nexpecting\tO\nthe\tO\nperformance\tB-aspectTerm\nof\tO\na\tO\nDesktop\tO\nit\tO\ndoes\tO\nnot\tO\nmeet\tO\nthe\tO\nexpectations\tO\n.\tO\n\nThe\tT-0\nMacbook\tT-0\narrived\tT-0\nin\tT-0\na\tT-0\nnice\tT-0\ntwin\tB-aspectTerm\npacking\tI-aspectTerm\nand\tO\nsealed\tT-1\nin\tO\nthe\tO\nbox\tO\n,\tO\nall\tO\nthe\tO\nfunctions\tO\nworks\tO\ngreat\tO\n.\tO\n\nThe\tO\nMacbook\tO\narrived\tO\nin\tO\na\tO\nnice\tT-1\ntwin\tO\npacking\tT-2\nand\tO\nsealed\tT-0\nin\tO\nthe\tO\nbox\tO\n,\tO\nall\tO\nthe\tO\nfunctions\tB-aspectTerm\nworks\tO\ngreat\tO\n.\tO\n\nSo\tO\nwhat\tO\nif\tO\nthe\tO\nlaptops\tT-1\n/\tO\nmobile\tT-2\nphones\tT-0\nlook\tB-aspectTerm\nchic\tO\nand\tO\ncool\tO\n?\tO\nThe\tO\nafter\tO\nsales\tO\nsupport\tO\nis\tO\nterrible\tO\n.\tO\n\nSo\tO\nwhat\tO\nif\tO\nthe\tO\nlaptops\tT-0\n/\tO\nmobile\tT-1\nphones\tT-1\nlook\tO\nchic\tT-2\nand\tO\ncool\tT-3\n?\tO\nThe\tO\nafter\tB-aspectTerm\nsales\tI-aspectTerm\nsupport\tI-aspectTerm\nis\tO\nterrible\tO\n.\tT-4\n\nI\tO\nhate\tO\nthe\tO\ndisplay\tB-aspectTerm\nscreen\tI-aspectTerm\nand\tO\nI\tO\nhave\tO\ndone\tO\neverything\tO\nI\tO\ncould\tO\ndo\tO\nthe\tO\nchange\tT-0\nit\tT-0\n.\tO\n\nI\tO\nalso\tO\nlike\tO\nthe\tO\nacer\tB-aspectTerm\narcade\tI-aspectTerm\nbut\tO\nthese\tT-0\nwere\tO\nreallythe\tO\nonly\tO\ntwo\tO\nthings\tT-1\nI\tO\nliked\tT-2\nabout\tO\nthis\tO\nlaptop\tT-3\n.\tO\n\nHave\tO\nnot\tO\nyet\tO\nneeded\tO\nany\tO\ncustomer\tB-aspectTerm\nsupport\tI-aspectTerm\nwith\tO\nthis\tO\nyet\tO\nso\tO\nto\tO\nme\tO\nthat\tO\nis\tO\na\tO\ngreat\tO\nthing\tO\n,\tO\nwhich\tO\nis\tO\nleaps\tT-0\nand\tT-0\nbounds\tT-0\nahead\tT-0\nof\tO\nPC\tO\nin\tO\nmy\tO\nopinion\tO\n.\tO\n\nI\tO\ngave\tO\nit\tO\nto\tO\nmy\tO\ndaughter\tO\nbecause\tO\nI\tO\njust\tO\nhated\tO\nthe\tO\nscreen\tB-aspectTerm\n,\tO\nhated\tO\nthat\tO\nit\tO\nhad\tO\nno\tO\ncd\tO\ndrive\tO\nto\tO\nat\tO\nleast\tO\nplay\tT-1\ncd\tT-0\n's\tT-0\nwhen\tO\nI\tO\nwanted\tO\nto\tO\nlisten\tO\nto\tO\nmusic\tO\nand\tO\ndo\tO\nschoolwork\tO\n.\tO\n\nI\tO\ngave\tO\nit\tO\nto\tO\nmy\tO\ndaughter\tO\nbecause\tT-1\nI\tO\njust\tO\nhated\tO\nthe\tO\nscreen\tO\n,\tO\nhated\tT-0\nthat\tO\nit\tO\nhad\tO\nno\tO\ncd\tB-aspectTerm\ndrive\tI-aspectTerm\nto\tO\nat\tO\nleast\tO\nplay\tO\ncd\tO\n's\tO\nwhen\tO\nI\tO\nwanted\tO\nto\tO\nlisten\tO\nto\tO\nmusic\tO\nand\tO\ndo\tO\nschoolwork\tO\n.\tO\n\nIt\tO\nruns\tB-aspectTerm\nvery\tO\nquiet\tT-0\ntoo\tO\nwhich\tO\nis\tO\na\tO\nplus\tO\n.\tO\n\nIt\tO\nwas\tO\nheavy\tO\n,\tO\nbulky\tO\n,\tO\nand\tO\nhard\tO\nto\tO\ncarry\tO\nbecause\tT-0\nof\tO\nthe\tO\nsize\tB-aspectTerm\n.\tO\n\nThe\tO\ngames\tB-aspectTerm\nincluded\tT-0\nare\tO\nvery\tO\ngood\tO\ngames\tO\n.\tO\n\nThe\tO\ngames\tT-1\nincluded\tT-0\nare\tO\nvery\tO\ngood\tO\ngames\tB-aspectTerm\n.\tO\n\nthis\tO\ncomputer\tT-0\nwill\tO\nlast\tO\nyou\tO\nat\tO\nleast\tO\n7\tO\nyears\tO\n,\tO\nthat\tO\ns\tO\nan\tO\namazing\tO\nlife\tB-aspectTerm\nspanned\tT-2\nan\tO\nelectronic\tT-1\n.\tO\n\nSometimes\tO\nyou\tO\nreally\tO\nhave\tT-0\nto\tT-0\ntap\tT-1\nthe\tT-1\npad\tB-aspectTerm\nto\tO\nget\tO\nit\tO\nto\tO\nworki\tO\n\nIt\tO\n's\tO\nsuper\tO\nfast\tO\nand\tO\na\tO\ngreat\tO\nvalue\tB-aspectTerm\nfor\tO\nthe\tO\nprice\tT-0\n!\tO\n\nIt\tO\n's\tO\nsuper\tO\nfast\tT-0\nand\tO\na\tO\ngreat\tO\nvalue\tT-1\nfor\tO\nthe\tO\nprice\tB-aspectTerm\n!\tO\n\nThree\tO\n,\tO\nthe\tO\nmac\tO\nbook\tO\nhas\tO\nadvantages\tT-1\nover\tO\npcs\tO\n'\tO\nwith\tO\nlinux\tB-aspectTerm\nbased\tI-aspectTerm\nos\tI-aspectTerm\nthere\tO\nis\tO\nvery\tO\n'\tO\nfew\tO\nproblems\tO\nwith\tO\nsystem\tT-0\nperformance\tO\nwhen\tO\nit\tO\ncomes\tO\nto\tO\na\tO\nmac\tO\n.\tO\n\nThree\tO\n,\tO\nthe\tO\nmac\tO\nbook\tO\nhas\tO\nadvantages\tO\nover\tO\npcs\tO\n'\tO\nwith\tO\nlinux\tO\nbased\tO\nos\tO\nthere\tO\nis\tO\nvery\tO\n'\tO\nfew\tT-0\nproblems\tT-0\nwith\tO\nsystem\tB-aspectTerm\nperformance\tI-aspectTerm\nwhen\tO\nit\tO\ncomes\tO\nto\tO\na\tO\nmac\tO\n.\tO\n\nA\tO\nmac\tT-0\nis\tO\nvery\tO\neasy\tO\nto\tO\nuse\tB-aspectTerm\nand\tO\nit\tO\nsimply\tT-1\nmakes\tO\nsense\tO\n.\tO\n\nhowever\tO\n,\tO\nI\tO\nmay\tO\nhave\tO\ninadvertently\tO\nthrown\tT-0\nout\tT-0\none\tO\nof\tO\nthe\tO\nbatteries\tB-aspectTerm\nwith\tO\nthe\tO\nshipping\tT-1\ncarton\tT-1\n.\tO\n\nhowever\tO\n,\tO\nI\tO\nmay\tO\nhave\tO\ninadvertently\tO\nthrown\tT-0\nout\tO\none\tO\nof\tO\nthe\tO\nbatteries\tT-1\nwith\tO\nthe\tO\nshipping\tB-aspectTerm\ncarton\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nso\tO\nmuch\tO\neasier\tT-0\nto\tO\nuse\tB-aspectTerm\n\nThere\tO\nis\tO\nno\tO\nneed\tO\nto\tO\nopen\tO\na\tO\nprogram\tB-aspectTerm\nfirst\tO\nand\tO\nthe\tO\ncliick\tT-0\nopen\tT-1\nor\tO\nimport\tT-2\n.\tO\n\nIt\tO\nis\tO\nso\tO\nnice\tO\nnot\tO\nto\tO\nworry\tT-0\nabout\tT-0\nthat\tO\nand\tO\nthe\tO\nextra\tO\nexpense\tT-1\nthat\tO\ncomes\tO\nalong\tO\nwith\tO\nthe\tO\nnecessary\tO\nvirus\tB-aspectTerm\nprotection\tI-aspectTerm\non\tO\nPC\tT-2\n's\tT-2\n.\tO\n\nThree\tO\nweeks\tO\nafter\tO\nI\tO\nbought\tO\nthe\tO\nnetbook\tT-1\n,\tO\nthe\tO\nscreen\tB-aspectTerm\nquit\tO\nworking\tT-0\n.\tO\n\nThe\tO\nprocessor\tB-aspectTerm\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tO\nOSX\tO\n16\tO\nfunctions\tO\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tT-0\nare\tO\nrouted\tT-2\nthrough\tO\nthe\tO\nhardware\tT-1\nrather\tO\nthan\tO\nthe\tO\nsoftware\tT-3\n.\tO\n\nThe\tO\nprocessor\tT-1\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tT-0\nthat\tO\nApple\tO\nOSX\tB-aspectTerm\n16\tI-aspectTerm\nfunctions\tO\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tT-2\nare\tO\nrouted\tO\nthrough\tO\nthe\tO\nhardware\tT-3\nrather\tO\nthan\tO\nthe\tO\nsoftware\tO\n.\tO\n\nThe\tO\nprocessor\tT-0\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tO\nOSX\tO\n16\tO\nfunctions\tT-2\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tB-aspectTerm\nare\tO\nrouted\tT-4\nthrough\tO\nthe\tO\nhardware\tT-1\nrather\tO\nthan\tO\nthe\tO\nsoftware\tT-3\n.\tO\n\nThe\tO\nprocessor\tT-0\nscreams\tO\n,\tO\nand\tO\nbecause\tO\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tT-1\nOSX\tT-1\n16\tT-1\nfunctions\tO\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tO\nare\tO\nrouted\tO\nthrough\tO\nthe\tO\nhardware\tB-aspectTerm\nrather\tO\nthan\tO\nthe\tO\nsoftware\tT-2\n.\tO\n\nThe\tO\nprocessor\tT-1\nscreams\tO\n,\tO\nand\tO\nbecause\tT-0\nof\tO\nthe\tO\nunique\tO\nway\tO\nthat\tO\nApple\tO\nOSX\tO\n16\tO\nfunctions\tT-2\n,\tO\nmost\tO\nof\tO\nthe\tO\ngraphics\tO\nare\tO\nrouted\tT-3\nthrough\tO\nthe\tO\nhardware\tO\nrather\tO\nthan\tO\nthe\tO\nsoftware\tB-aspectTerm\n.\tO\n\nI\tO\nwanted\tO\nsomething\tO\nthat\tO\nhad\tT-2\na\tO\nnew\tT-3\nIntel\tB-aspectTerm\nCore\tI-aspectTerm\nprocessors\tI-aspectTerm\nand\tO\nHDMI\tO\nport\tO\nso\tO\nthat\tO\nwe\tO\ncould\tO\nhook\tT-0\nit\tT-0\nup\tT-0\ndirectly\tO\nto\tT-1\nour\tT-1\nTV\tT-1\n.\tO\n\nI\tO\nwanted\tT-0\nsomething\tO\nthat\tO\nhad\tO\na\tO\nnew\tO\nIntel\tO\nCore\tO\nprocessors\tO\nand\tO\nHDMI\tB-aspectTerm\nport\tI-aspectTerm\nso\tO\nthat\tO\nwe\tO\ncould\tO\nhook\tT-1\nit\tO\nup\tT-2\ndirectly\tO\nto\tO\nour\tO\nTV\tT-3\n.\tO\n\nThe\tO\nApple\tO\nwill\tO\nrun\tT-0\nInternet\tB-aspectTerm\nExplorer\tI-aspectTerm\n,\tO\nbut\tO\nat\tO\nan\tO\namazingly\tO\nslow\tO\nrate\tO\n.\tO\n\nWith\tO\ntoday\tO\n's\tO\ncompany\tO\nfighting\tO\nover\tO\nmarketshare\tO\n,\tO\nits\tO\na\tO\nshame\tT-1\nthat\tO\nASUS\tO\ncan\tO\nget\tO\naway\tO\nwith\tO\nthe\tO\ninept\tO\nstaff\tB-aspectTerm\nanswering\tT-0\nthephone\tT-0\n.\tO\n\nThe\tO\nprice\tB-aspectTerm\npremium\tI-aspectTerm\nis\tO\na\tO\nlittle\tT-0\nmuch\tT-0\n,\tO\nbut\tO\nwhen\tO\nyou\tO\nstart\tO\nlooking\tO\nat\tO\nthe\tO\nfeatures\tT-1\nit\tO\nis\tO\nworth\tO\nthe\tO\nadded\tO\ncash\tO\n.\tO\n\nThe\tO\nprice\tT-1\npremium\tT-1\nis\tO\na\tO\nlittle\tO\nmuch\tO\n,\tO\nbut\tO\nwhen\tO\nyou\tO\nstart\tO\nlooking\tO\nat\tO\nthe\tO\nfeatures\tB-aspectTerm\nit\tO\nis\tO\nworth\tO\nthe\tO\nadded\tT-0\ncash\tO\n.\tO\n\nMicrosoft\tB-aspectTerm\nword\tI-aspectTerm\nwas\tO\nnot\tO\non\tT-0\nit\tO\nandI\tO\nhad\tO\nto\tO\nbuy\tO\nit\tO\nseperately\tT-1\n.\tO\n\nit\tO\nhas\tO\n3\tT-1\nusb\tB-aspectTerm\nports\tI-aspectTerm\n,\tO\n1\tO\nsd\tO\nmemory\tO\ncard\tO\nreader\tO\nand\tO\nan\tO\nsd\tO\nmemory\tO\ncar\tO\nexpansion\tT-0\n.\tO\n\nit\tO\nhas\tO\n3\tO\nusb\tO\nports\tO\n,\tO\n1\tT-3\nsd\tB-aspectTerm\nmemory\tI-aspectTerm\ncard\tI-aspectTerm\nreader\tI-aspectTerm\nand\tO\nan\tO\nsd\tO\nmemory\tT-1\ncar\tO\nexpansion\tT-2\n.\tT-0\n\nit\tO\nhas\tO\n3\tO\nusb\tT-0\nports\tO\n,\tO\n1\tT-1\nsd\tT-1\nmemory\tT-1\ncard\tT-1\nreader\tT-1\nand\tO\nan\tO\nsd\tB-aspectTerm\nmemory\tI-aspectTerm\ncar\tI-aspectTerm\nexpansion\tI-aspectTerm\n.\tO\n\nI\tO\nconnect\tT-1\na\tO\nLaCie\tB-aspectTerm\n2Big\tI-aspectTerm\nexternal\tI-aspectTerm\ndrive\tI-aspectTerm\nvia\tO\nthe\tO\nfirewire\tT-2\n800\tT-2\ninterface\tT-2\n,\tO\nwhich\tT-0\nis\tO\nuseful\tO\nfor\tO\nTime\tT-3\nMachine\tT-3\n.\tO\n\nI\tO\nconnect\tT-0\na\tO\nLaCie\tO\n2Big\tO\nexternal\tT-2\ndrive\tT-3\nvia\tO\nthe\tO\nfirewire\tB-aspectTerm\n800\tI-aspectTerm\ninterface\tI-aspectTerm\n,\tO\nwhich\tO\nis\tO\nuseful\tO\nfor\tO\nTime\tT-1\nMachine\tT-1\n.\tO\n\nI\tO\nconnect\tT-0\na\tO\nLaCie\tT-1\n2Big\tT-1\nexternal\tT-1\ndrive\tT-1\nvia\tO\nthe\tO\nfirewire\tT-2\n800\tT-2\ninterface\tO\n,\tO\nwhich\tO\nis\tO\nuseful\tT-3\nfor\tT-3\nTime\tB-aspectTerm\nMachine\tI-aspectTerm\n.\tO\n\nMy\tO\nToshiba\tT-0\ndid\tO\nnot\tO\nhave\tO\nsound\tB-aspectTerm\non\tO\neverything\tO\n,\tO\njust\tO\ncertain\tO\nthings\tO\n.\tO\n\nI\tO\nam\tO\noverall\tO\nvery\tO\npleased\tO\nwith\tO\nmy\tO\ntoshiba\tT-1\nsatellite\tT-2\n,\tO\nI\tO\nlike\tO\nthe\tO\nextra\tB-aspectTerm\nfeatures\tI-aspectTerm\n,\tO\nI\tO\nlove\tO\nthe\tO\nwindows\tT-0\n7\tO\nhome\tO\npremium\tT-3\n.\tO\n\nI\tO\nam\tO\noverall\tO\nvery\tO\npleased\tO\nwith\tO\nmy\tO\ntoshiba\tO\nsatellite\tO\n,\tO\nI\tO\nlike\tO\nthe\tO\nextra\tT-0\nfeatures\tO\n,\tO\nI\tO\nlove\tO\nthe\tO\nwindows\tB-aspectTerm\n7\tI-aspectTerm\nhome\tI-aspectTerm\npremium\tI-aspectTerm\n.\tO\n\nThe\tO\nAspire\tO\nwo\tO\nnt\tO\neven\tO\nboot\tB-aspectTerm\npast\tT-1\nthe\tT-1\nAcer\tO\nscreen\tO\nwith\tO\na\tO\nDroid\tO\n(\tO\nI\tO\nhave\tO\ntried\tO\nboth\tO\nMotorola\tO\nand\tO\nHTC\tO\n)\tO\nplugged\tT-2\ninto\tO\nthe\tO\nUSB\tO\nport\tO\n.\tT-0\n\nThe\tO\nAspire\tT-0\nwo\tO\nnt\tO\neven\tO\nboot\tO\npast\tT-3\nthe\tO\nAcer\tB-aspectTerm\nscreen\tI-aspectTerm\nwith\tO\na\tO\nDroid\tO\n(\tO\nI\tO\nhave\tO\ntried\tO\nboth\tO\nMotorola\tO\nand\tO\nHTC\tO\n)\tO\nplugged\tT-2\ninto\tO\nthe\tO\nUSB\tT-1\nport\tT-1\n.\tO\n\nThe\tO\nAspire\tO\nwo\tO\nnt\tO\neven\tO\nboot\tT-1\npast\tO\nthe\tO\nAcer\tO\nscreen\tO\nwith\tO\na\tO\nDroid\tO\n(\tO\nI\tO\nhave\tO\ntried\tO\nboth\tO\nMotorola\tO\nand\tO\nHTC\tO\n)\tO\nplugged\tT-0\ninto\tT-0\nthe\tO\nUSB\tB-aspectTerm\nport\tI-aspectTerm\n.\tO\n\nThe\tO\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\nwas\tO\nshorter\tT-0\nthan\tO\nexpected\tO\n.\tO\n\nIt\tO\nfires\tB-aspectTerm\nup\tI-aspectTerm\nin\tO\nthe\tO\nmorning\tO\nin\tO\nless\tO\nthan\tO\n30\tO\nseconds\tT-1\nand\tO\nI\tO\nhave\tO\nnever\tO\nhad\tO\nany\tO\nissues\tO\nwith\tO\nit\tO\nfreezing\tT-0\n.\tO\n\nThe\tT-1\nkeyboard\tB-aspectTerm\nis\tT-2\ntop\tT-2\nnotch\tT-2\n.\tT-0\n\nIt\tO\ndrives\tO\nme\tO\ncrazy\tO\nwhen\tO\nI\tO\nwant\tO\nto\tO\ndownload\tO\na\tO\ngame\tO\nor\tO\nsomething\tO\nof\tO\nthat\tO\nnature\tT-0\nand\tO\nI\tO\nca\tO\nn't\tO\nplay\tO\nit\tO\nbecause\tO\nits\tO\nnot\tO\ncompatable\tT-1\nwith\tO\nthe\tO\nsoftware\tB-aspectTerm\n.\tO\n\nThe\tO\nonline\tB-aspectTerm\ntutorial\tI-aspectTerm\nvideos\tI-aspectTerm\nmake\tO\nit\tO\nsuper\tO\neasy\tT-1\nto\tT-1\nlearn\tT-1\nif\tO\nyou\tO\nhave\tO\nalways\tO\nused\tT-0\na\tO\nPC\tO\n.\tO\n\nThe\tO\nimage\tB-aspectTerm\nis\tO\ngreat\tT-0\n,\tO\nand\tO\nthe\tO\nsoud\tT-2\nis\tO\nexcelent\tT-1\n.\tO\n\nThe\tO\nimage\tO\nis\tO\ngreat\tO\n,\tO\nand\tO\nthe\tO\nsoud\tB-aspectTerm\nis\tO\nexcelent\tT-0\n.\tO\n\nWith\tO\na\tO\nMAC\tO\ncomputer\tO\nI\tO\nhave\tO\nmore\tO\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tT-2\nto\tO\nwait\tT-1\nfor\tT-1\nwindows\tB-aspectTerm\nto\tT-0\nboot\tT-0\nup\tT-0\nor\tT-0\nshut\tT-0\ndown\tT-0\nand\tO\nall\tO\nthe\tO\nviruses\tO\nassociated\tO\nwith\tO\nwindows\tO\n.\tO\n\nWith\tO\na\tO\nMAC\tO\ncomputer\tO\nI\tO\nhave\tO\nmore\tT-3\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nwait\tO\nfor\tO\nwindows\tT-0\nto\tO\nboot\tB-aspectTerm\nup\tI-aspectTerm\nor\tO\nshut\tT-1\ndown\tT-1\nand\tO\nall\tO\nthe\tO\nviruses\tT-2\nassociated\tO\nwith\tO\nwindows\tO\n.\tO\n\nWith\tO\na\tO\nMAC\tO\ncomputer\tO\nI\tO\nhave\tO\nmore\tT-0\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nwait\tO\nfor\tO\nwindows\tO\nto\tO\nboot\tO\nup\tO\nor\tO\nshut\tB-aspectTerm\ndown\tI-aspectTerm\nand\tO\nall\tO\nthe\tO\nviruses\tO\nassociated\tO\nwith\tO\nwindows\tO\n.\tO\n\nWith\tO\na\tO\nMAC\tT-0\ncomputer\tT-0\nI\tO\nhave\tO\nmore\tO\nfree\tO\ntime\tO\nas\tO\nI\tO\ndo\tO\nn't\tO\nhave\tO\nto\tO\nwait\tO\nfor\tO\nwindows\tT-1\nto\tO\nboot\tO\nup\tO\nor\tO\nshut\tO\ndown\tO\nand\tO\nall\tO\nthe\tO\nviruses\tT-2\nassociated\tO\nwith\tO\nwindows\tB-aspectTerm\n.\tO\n\nIt\tO\nwas\tO\nvery\tO\neasy\tO\nto\tO\njust\tO\npick\tT-1\nup\tT-1\nand\tO\nuse--\tB-aspectTerm\nIt\tO\ndid\tO\nnot\tO\ntake\tO\nlong\tO\nto\tO\nget\tO\nused\tO\nto\tO\nthe\tO\nMac\tO\nOS\tO\n.\tT-0\n\nIt\tO\nwas\tO\nvery\tO\neasy\tO\nto\tO\njust\tO\npick\tO\nup\tO\nand\tO\nuse--\tO\nIt\tO\ndid\tO\nnot\tO\ntake\tO\nlong\tO\nto\tO\nget\tT-0\nused\tT-0\nto\tT-0\nthe\tO\nMac\tB-aspectTerm\nOS\tI-aspectTerm\n.\tO\n\nIt\tO\nis\tO\nwell\tO\nworth\tO\nthe\tO\nmoney\tT-1\nit\tO\ncost\tB-aspectTerm\n,\tO\nVery\tO\ngood\tO\ninvestment\tT-2\n.\tT-0\n\nUpgrading\tT-2\nfrom\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nStarter\tI-aspectTerm\n,\tO\nthru\tO\nWindows\tT-0\n7\tT-0\nHome\tT-0\nPremium\tT-0\n,\tO\nto\tO\nWindows\tT-1\n7\tT-1\nProfessional\tT-1\nwas\tO\na\tO\nsnap\tO\n;\tO\n\nUpgrading\tT-0\nfrom\tO\nWindows\tO\n7\tO\nStarter\tT-2\n,\tO\nthru\tO\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nHome\tI-aspectTerm\nPremium\tI-aspectTerm\n,\tO\nto\tO\nWindows\tO\n7\tO\nProfessional\tT-1\nwas\tO\na\tO\nsnap\tO\n;\tT-1\n\nUpgrading\tT-0\nfrom\tO\nWindows\tO\n7\tO\nStarter\tO\n,\tO\nthru\tO\nWindows\tO\n7\tO\nHome\tO\nPremium\tO\n,\tO\nto\tT-1\nWindows\tB-aspectTerm\n7\tI-aspectTerm\nProfessional\tI-aspectTerm\nwas\tO\na\tO\nsnap\tO\n;\tO\n\nMy\tO\nkids\tO\n(\tO\nand\tO\ndogs\tT-0\n)\tO\ndestroyed\tO\ntwo\tO\npower\tB-aspectTerm\ncords\tI-aspectTerm\nby\tO\npulling\tT-1\non\tT-1\nthem\tT-1\n.\tO\n\nI\tO\nhad\tO\nupgraded\tT-1\nmy\tO\nold\tO\nMacBook\tO\nto\tO\nLion\tO\n,\tO\nso\tO\nI\tO\nkind\tO\nof\tO\nknew\tO\nwhat\tO\nI\tO\nwas\tO\ngetting\tO\n,\tO\nbut\tO\nhad\tO\nn't\tO\nbeen\tO\nable\tO\nto\tO\nenjoy\tO\nsome\tO\nof\tO\nthe\tO\nawesome\tO\nnew\tT-0\nmulti\tB-aspectTerm\n-\tI-aspectTerm\ntouch\tI-aspectTerm\nfeatures\tI-aspectTerm\n.\tO\n\nThe\tO\nscreen\tB-aspectTerm\nis\tO\na\tT-1\nlittle\tT-1\nglary\tT-1\n,\tO\nand\tO\nI\tO\nhated\tO\nthe\tO\nclicking\tT-2\nbuttons\tT-2\n,\tO\nbut\tO\nI\tO\ngot\tO\nused\tO\nto\tO\nthem\tO\n.\tO\n\nThe\tO\nscreen\tO\nis\tO\na\tO\nlittle\tO\nglary\tT-0\n,\tO\nand\tO\nI\tO\nhated\tO\nthe\tO\nclicking\tB-aspectTerm\nbuttons\tI-aspectTerm\n,\tO\nbut\tO\nI\tO\ngot\tO\nused\tO\nto\tO\nthem\tO\n.\tO\n\nnot\tT-0\nusing\tT-0\nwired\tB-aspectTerm\nlan\tI-aspectTerm\nnot\tO\nsure\tO\nwhat\tO\nthat\tO\ns\tO\nabout\tO\n.\tO\n\nThe\tO\nmacbook\tO\nrarely\tT-0\nrequires\tT-1\na\tT-1\nhard\tB-aspectTerm\nreboot\tI-aspectTerm\n.\tO\n\nNow\tO\nfor\tO\nthe\tO\nhardware\tB-aspectTerm\nproblems\tT-0\n.\tO\n\nAnyways\tO\nI\tO\nbought\tO\nthis\tO\ntwo\tO\nmonths\tO\nago\tO\nand\tO\nwhen\tO\nI\tO\nfirst\tO\nbrought\tO\nit\tO\nhome\tT-0\nit\tO\nkept\tO\ngiving\tO\nme\tO\na\tO\nmessage\tT-1\nabout\tO\na\tO\nvibration\tT-2\nin\tO\nthe\tO\nhard\tB-aspectTerm\ndrive\tI-aspectTerm\nand\tO\nit\tO\nis\tO\nputting\tO\nit\tO\ntemporaly\tO\nin\tO\nsave\tT-3\nzone\tT-3\n.\tO\n\nIt\tO\n's\tO\nfast\tO\nand\tO\nhas\tO\nexcellent\tT-1\nbattery\tB-aspectTerm\nlife\tI-aspectTerm\n.\tT-0\n\nFeatures\tB-aspectTerm\nlike\tO\nthe\tO\nfont\tT-1\nare\tO\nvery\tO\nblock\tT-0\n-\tO\nlike\tO\nand\tO\nold\tO\nschool\tO\n.\tO\n\nFeatures\tO\nlike\tO\nthe\tO\nfont\tB-aspectTerm\nare\tO\nvery\tO\nblock\tT-0\n-\tT-0\nlike\tT-0\nand\tO\nold\tT-1\nschool\tT-1\n.\tT-1\n\nIt\tO\nis\tO\nloaded\tT-1\nwith\tT-1\nprograms\tB-aspectTerm\nthat\tO\nis\tO\nof\tO\nno\tO\ngood\tO\nfor\tO\nthe\tO\naverage\tT-0\nuser\tO\n,\tO\nthat\tO\nmakes\tO\nit\tO\nrun\tO\nway\tO\nto\tO\nslow\tO\n.\tO\n\nIt\tO\nis\tO\nloaded\tO\nwith\tO\nprograms\tT-0\nthat\tO\nis\tO\nof\tO\nno\tO\ngood\tO\nfor\tO\nthe\tO\naverage\tO\nuser\tO\n,\tO\nthat\tO\nmakes\tO\nit\tO\nrun\tB-aspectTerm\nway\tT-1\nto\tT-1\nslow\tT-1\n.\tO\n\nI\tO\nfeel\tO\nthat\tO\nit\tO\nwas\tO\npoorly\tT-0\nput\tO\ntogether\tO\n,\tO\nbecause\tO\nonce\tO\nin\tO\na\tO\nwhile\tO\ndifferent\tO\nplastic\tB-aspectTerm\nÂ\tI-aspectTerm\npieces\tI-aspectTerm\nÂ\tO\nwould\tO\ncome\tO\noff\tT-1\nof\tO\nit\tO\n.\tT-1\n\nFinally\tO\n,\tO\nI\tO\nshould\tO\nnote\tO\nthat\tO\nI\tO\ntook\tT-0\nthe\tO\n2\tB-aspectTerm\nGB\tI-aspectTerm\nRAM\tI-aspectTerm\nstick\tI-aspectTerm\nfrom\tT-1\nmy\tO\nold\tO\nEeePC\tO\nand\tO\ninstalled\tT-2\nit\tO\nbefore\tO\nI\tO\neven\tO\npowered\tO\non\tO\nfor\tO\nthe\tO\nfirst\tO\ntime\tO\n.\tO\n\nWindows\tB-aspectTerm\nis\tO\nalso\tO\nrather\tO\nunsteady\tT-0\non\tO\nits\tO\nfeet\tO\nand\tO\nis\tO\nsusceptible\tT-1\nto\tO\nmany\tO\nbugs\tO\n.\tO\n\nAfter\tO\nsending\tO\nout\tO\ndocuments\tO\nvia\tO\nemail\tO\nand\tO\nhaving\tO\nrecipients\tO\ntell\tO\nme\tO\nthey\tO\ncould\tO\nnot\tO\nopen\tO\nthe\tO\ndocuments\tO\nor\tO\nthey\tO\ncame\tO\nthrough\tO\nas\tO\ngibberish\tO\n,\tO\nI\tO\nbroke\tO\ndown\tO\nand\tO\nspent\tT-0\nanother\tO\n$\tO\n100\tO\nto\tO\nget\tO\nMicrosoft\tB-aspectTerm\nWord\tI-aspectTerm\nfor\tI-aspectTerm\nMac\tI-aspectTerm\n.\tO\n\n"
  },
  {
    "path": "model/__init__.py",
    "content": "from model.charbilstm import CharBiLSTM\n"
  },
  {
    "path": "model/charbilstm.py",
    "content": "# \n# @author: Allan\n#\nimport torch\nimport torch.nn as nn\nfrom torch.nn.utils.rnn import pack_padded_sequence, pad_packed_sequence\nfrom overrides import overrides\n\n\nclass CharBiLSTM(nn.Module):\n\n    def __init__(self, config, print_info: bool = True):\n        super(CharBiLSTM, self).__init__()\n        if print_info:\n            print(\"[Info] Building character-level LSTM\")\n        self.char_emb_size = config.char_emb_size\n        self.char2idx = config.char2idx\n        self.chars = config.idx2char\n        self.char_size = len(self.chars)\n        self.device = config.device\n        self.hidden = config.charlstm_hidden_dim\n        self.dropout = nn.Dropout(config.dropout).to(self.device)\n        self.char_embeddings = nn.Embedding(self.char_size, self.char_emb_size).to(self.device)\n        self.char_lstm = nn.LSTM(self.char_emb_size, self.hidden // 2 ,num_layers=1, batch_first=True, bidirectional=True).to(self.device)\n\n    @overrides\n    def forward(self, char_seq_tensor: torch.Tensor, char_seq_len: torch.Tensor) -> torch.Tensor:\n        \"\"\"\n        Get the last hidden states of the LSTM\n            input:\n                char_seq_tensor: (batch_size, sent_len, word_length)\n                char_seq_len: (batch_size, sent_len)\n            output:\n                Variable(batch_size, sent_len, char_hidden_dim )\n        \"\"\"\n        batch_size = char_seq_tensor.size(0)\n        sent_len = char_seq_tensor.size(1)\n        char_seq_tensor = char_seq_tensor.view(batch_size * sent_len, -1)\n        char_seq_len = char_seq_len.view(batch_size * sent_len)\n        sorted_seq_len, permIdx = char_seq_len.sort(0, descending=True)\n        _, recover_idx = permIdx.sort(0, descending=False)\n        sorted_seq_tensor = char_seq_tensor[permIdx]\n\n        char_embeds = self.dropout(self.char_embeddings(sorted_seq_tensor))\n        pack_input = pack_padded_sequence(char_embeds, sorted_seq_len.cpu(), batch_first=True)\n\n        _, char_hidden = self.char_lstm(pack_input, None)\n        hidden = char_hidden[0].transpose(1,0).contiguous().view(batch_size * sent_len, 1, -1)   ### before view, the size is ( batch_size * sent_len, 2, lstm_dimension) 2 means 2 direciton..\n        return hidden[recover_idx].view(batch_size, sent_len, -1)\n\n\n"
  },
  {
    "path": "model/linear_crf_inferencer.py",
    "content": "#\n# @author: Allan\n#\nimport torch.nn as nn\nimport torch\n\nfrom config import log_sum_exp_pytorch, START, STOP, PAD\nfrom typing import Tuple\nfrom overrides import overrides\n\nclass LinearCRF(nn.Module):\n\n    def __init__(self, config, print_info: bool = True):\n        super(LinearCRF, self).__init__()\n\n        self.label_size = config.label_size\n        self.device = config.device\n        self.use_char = config.use_char_rnn\n        self.context_emb = config.context_emb\n\n        self.label2idx = config.label2idx\n        self.labels = config.idx2labels\n        self.start_idx = self.label2idx[START]\n        self.end_idx = self.label2idx[STOP]\n        self.pad_idx = self.label2idx[PAD]\n\n        # initialize the following transition (anything never -> start. end never -> anything. Same thing for the padding label)\n        self.init_transition = torch.randn(self.label_size, self.label_size).to(self.device)\n        self.init_transition[:, self.start_idx] = -10000.0\n        self.init_transition[self.end_idx, :] = -10000.0\n        self.init_transition[:, self.pad_idx] = -10000.0\n        self.init_transition[self.pad_idx, :] = -10000.0\n\n        self.transition = nn.Parameter(self.init_transition)\n\n    @overrides\n    def forward(self, lstm_scores, word_seq_lens, tags, mask):\n        \"\"\"\n        Calculate the negative log-likelihood\n        :param lstm_scores:\n        :param word_seq_lens:\n        :param tags:\n        :param mask:\n        :return:\n        \"\"\"\n        all_scores=  self.calculate_all_scores(lstm_scores= lstm_scores)\n        unlabed_score = self.forward_unlabeled(all_scores, word_seq_lens)\n        labeled_score = self.forward_labeled(all_scores, word_seq_lens, tags, mask)\n        return unlabed_score, labeled_score\n\n    def forward_unlabeled(self, all_scores: torch.Tensor, word_seq_lens: torch.Tensor) -> torch.Tensor:\n        \"\"\"\n        Calculate the scores with the forward algorithm. Basically calculating the normalization term\n        :param all_scores: (batch_size x max_seq_len x num_labels x num_labels) from (lstm scores + transition scores).\n        :param word_seq_lens: (batch_size)\n        :return: (batch_size) for the normalization scores\n        \"\"\"\n        batch_size = all_scores.size(0)\n        seq_len = all_scores.size(1)\n        alpha = torch.zeros(batch_size, seq_len, self.label_size).to(self.device)\n\n        alpha[:, 0, :] = all_scores[:, 0,  self.start_idx, :] ## the first position of all labels = (the transition from start - > all labels) + current emission.\n\n        for word_idx in range(1, seq_len):\n            ## batch_size, self.label_size, self.label_size\n            before_log_sum_exp = alpha[:, word_idx-1, :].view(batch_size, self.label_size, 1).expand(batch_size, self.label_size, self.label_size) + all_scores[:, word_idx, :, :]\n            alpha[:, word_idx, :] = log_sum_exp_pytorch(before_log_sum_exp)\n\n        ### batch_size x label_size\n        last_alpha = torch.gather(alpha, 1, word_seq_lens.view(batch_size, 1, 1).expand(batch_size, 1, self.label_size)-1).view(batch_size, self.label_size)\n        last_alpha += self.transition[:, self.end_idx].view(1, self.label_size).expand(batch_size, self.label_size)\n        last_alpha = log_sum_exp_pytorch(last_alpha.view(batch_size, self.label_size, 1)).view(batch_size)\n\n        return torch.sum(last_alpha)\n\n    def forward_labeled(self, all_scores: torch.Tensor, word_seq_lens: torch.Tensor, tags: torch.Tensor, masks: torch.Tensor) -> torch.Tensor:\n        '''\n        Calculate the scores for the gold instances.\n        :param all_scores: (batch, seq_len, label_size, label_size)\n        :param word_seq_lens: (batch, seq_len)\n        :param tags: (batch, seq_len)\n        :param masks: batch, seq_len\n        :return: sum of score for the gold sequences Shape: (batch_size)\n        '''\n        batchSize = all_scores.shape[0]\n        sentLength = all_scores.shape[1]\n\n        currentTagScores = torch.gather(all_scores, 3, tags.view(batchSize, sentLength, 1, 1).expand(batchSize, sentLength, self.label_size, 1)).view(batchSize, -1, self.label_size)\n        if sentLength != 1:\n            tagTransScoresMiddle = torch.gather(currentTagScores[:, 1:, :], 2, tags[:, : sentLength - 1].view(batchSize, sentLength - 1, 1)).view(batchSize, -1)\n        tagTransScoresBegin = currentTagScores[:, 0, self.start_idx]\n        endTagIds = torch.gather(tags, 1, word_seq_lens.view(batchSize, 1) - 1)\n        tagTransScoresEnd = torch.gather(self.transition[:, self.end_idx].view(1, self.label_size).expand(batchSize, self.label_size), 1,  endTagIds).view(batchSize)\n        score = torch.sum(tagTransScoresBegin) + torch.sum(tagTransScoresEnd)\n        if sentLength != 1:\n            score += torch.sum(tagTransScoresMiddle.masked_select(masks[:, 1:]))\n        return score\n\n    def calculate_all_scores(self, lstm_scores: torch.Tensor) -> torch.Tensor:\n        \"\"\"\n        Calculate all scores by adding up the transition scores and emissions (from lstm).\n        Basically, compute the scores for each edges between labels at adjacent positions.\n        This score is later be used for forward-backward inference\n        :param lstm_scores: emission scores.\n        :return:\n        \"\"\"\n        batch_size = lstm_scores.size(0)\n        seq_len = lstm_scores.size(1)\n        scores = self.transition.view(1, 1, self.label_size, self.label_size).expand(batch_size, seq_len, self.label_size, self.label_size) + \\\n                 lstm_scores.view(batch_size, seq_len, 1, self.label_size).expand(batch_size, seq_len, self.label_size, self.label_size)\n        return scores\n\n    def decode(self, features, wordSeqLengths, annotation_mask = None) -> Tuple[torch.Tensor, torch.Tensor]:\n        \"\"\"\n        Decode the batch input\n        :param batchInput:\n        :return:\n        \"\"\"\n        all_scores = self.calculate_all_scores(features)\n        bestScores, decodeIdx = self.constrainted_viterbi_decode(all_scores, wordSeqLengths, annotation_mask)\n        return bestScores, decodeIdx\n\n    def constrainted_viterbi_decode(self, all_scores: torch.Tensor, word_seq_lens: torch.Tensor, annotation_mask: torch.Tensor = None) -> Tuple[torch.Tensor, torch.Tensor]:\n        \"\"\"\n        Use viterbi to decode the instances given the scores and transition parameters\n        :param all_scores: (batch_size x max_seq_len x num_labels)\n        :param word_seq_lens: (batch_size)\n        :return: the best scores as well as the predicted label ids.\n               (batch_size) and (batch_size x max_seq_len)\n        \"\"\"\n        batchSize = all_scores.shape[0]\n        sentLength = all_scores.shape[1]\n        if annotation_mask is not None:\n            annotation_mask = annotation_mask.float().log()\n        # sent_len =\n        scoresRecord = torch.zeros([batchSize, sentLength, self.label_size]).to(self.device)\n        idxRecord = torch.zeros([batchSize, sentLength, self.label_size], dtype=torch.int64).to(self.device)\n        mask = torch.ones_like(word_seq_lens, dtype=torch.int64).to(self.device)\n        startIds = torch.full((batchSize, self.label_size), self.start_idx, dtype=torch.int64).to(self.device)\n        decodeIdx = torch.LongTensor(batchSize, sentLength).to(self.device)\n\n        scores = all_scores\n        # scoresRecord[:, 0, :] = self.getInitAlphaWithBatchSize(batchSize).view(batchSize, self.label_size)\n        scoresRecord[:, 0, :] = scores[:, 0, self.start_idx, :]  ## represent the best current score from the start, is the best\n        if annotation_mask is not None:\n            scoresRecord[:, 0, :] += annotation_mask[:, 0, :]\n        idxRecord[:,  0, :] = startIds\n        for wordIdx in range(1, sentLength):\n            ### scoresIdx: batch x from_label x to_label at current index.\n            scoresIdx = scoresRecord[:, wordIdx - 1, :].view(batchSize, self.label_size, 1).expand(batchSize, self.label_size,\n                                                                                  self.label_size) + scores[:, wordIdx, :, :]\n            if annotation_mask is not None:\n                scoresIdx += annotation_mask[:, wordIdx, :].view(batchSize, 1, self.label_size).expand(batchSize, self.label_size, self.label_size)\n\n            idxRecord[:, wordIdx, :] = torch.argmax(scoresIdx, 1)  ## the best previous label idx to crrent labels\n            scoresRecord[:, wordIdx, :] = torch.gather(scoresIdx, 1, idxRecord[:, wordIdx, :].view(batchSize, 1, self.label_size)).view(batchSize, self.label_size)\n\n        lastScores = torch.gather(scoresRecord, 1, word_seq_lens.view(batchSize, 1, 1).expand(batchSize, 1, self.label_size) - 1).view(batchSize, self.label_size)  ##select position\n        lastScores += self.transition[:, self.end_idx].view(1, self.label_size).expand(batchSize, self.label_size)\n        decodeIdx[:, 0] = torch.argmax(lastScores, 1)\n        bestScores = torch.gather(lastScores, 1, decodeIdx[:, 0].view(batchSize, 1))\n\n        for distance2Last in range(sentLength - 1):\n            lastNIdxRecord = torch.gather(idxRecord, 1, torch.where(word_seq_lens - distance2Last - 1 > 0, word_seq_lens - distance2Last - 1, mask).view(batchSize, 1, 1).expand(batchSize, 1, self.label_size)).view(batchSize, self.label_size)\n            decodeIdx[:, distance2Last + 1] = torch.gather(lastNIdxRecord, 1, decodeIdx[:, distance2Last].view(batchSize, 1)).view(batchSize)\n\n        return bestScores, decodeIdx"
  },
  {
    "path": "model/soft_attention.py",
    "content": "\"\"\"soft_attention.py: Structured Self-attention layer.\nIt creates trigger representations, and sentence representation with negative sampling.\nThe reason for negative sampling is to learn contrastive loss.\n\nWritten in 2020 by Dong-Ho Lee.\n\"\"\"\nimport torch\nimport torch.nn as nn\nimport random\n\n\nclass SoftAttention(nn.Module):\n    def __init__(self, config):\n        super(SoftAttention, self).__init__()\n        self.config = config\n        self.device = config.device\n\n        self.linear = nn.Linear(config.hidden_dim, config.hidden_dim // 2).to(self.device)\n        self.hops = config.hidden_dim // 8\n        self.ws1 = nn.Linear(config.hidden_dim // 2, config.hidden_dim // 4, bias=False).to(self.device)\n        self.ws2 = nn.Linear(config.hidden_dim // 4, self.hops, bias=False).to(self.device)\n        self.tanh = nn.Tanh().to(self.device)\n\n    def attention(self, lstm_output, mask):\n        \"\"\"\n        Calculate structured self attention.\n        :param lstm_output:\n        :param mask:\n        :return:\n        \"\"\"\n        lstm_output = self.linear(lstm_output)\n\n        size = lstm_output.size()\n        compressed_reps = lstm_output.contiguous().view(-1, size[2])\n        hbar = self.tanh(self.ws1(compressed_reps))  # (batch_size x seq_len) * attn_size\n        alphas = self.ws2(hbar).view(size[0], size[1], -1)  # batch_size * seq_len * hops\n        alphas = torch.transpose(alphas, 1, 2).contiguous().to(self.device)  # batch_size * hops * seq_len\n        multi_mask = [mask.unsqueeze(1) for i in range(self.hops)]\n        multi_mask = torch.cat(multi_mask, 1).to(self.device)\n\n        penalized_alphas = alphas + -1e7 * (1 - multi_mask)\n        alphas = torch.softmax(penalized_alphas.view(-1, size[1]),dim=-1).to(self.device)  # (batch_size x hops) * seq_len\n        alphas = alphas.view(size[0], self.hops, size[1])  # batch_size * hops * seq_len\n\n        lstm_output = torch.bmm(alphas, lstm_output).to(self.device)  # batch_size * hops * hidden_size\n        lstm_output = lstm_output.mean(1)\n        return lstm_output\n\n    def forward(self, sentence_vec, sentence_mask, trigger_vec, trigger_mask):\n        \"\"\"\n        Get attention for sentence and trigger. For sentence, generate negative samples\n        :param sentence_vec:\n        :param sentence_mask:\n        :param trigger_vec:\n        :param trigger_mask:\n        :return:\n        \"\"\"\n        sent_rep = self.attention(sentence_vec, sentence_mask)\n        trig_rep = self.attention(trigger_vec, trigger_mask)\n\n        # generating negative samples\n        trigger_vec_cat = torch.cat([trig_rep, trig_rep], dim=0)\n        random.seed(1000)\n        row_idxs = list(range(sent_rep.shape[0]))\n        random.shuffle(row_idxs)\n        sentence_vec_rand = sent_rep[torch.tensor(row_idxs), :]\n        sentence_vec_cat = torch.cat([sent_rep, sentence_vec_rand], dim=0)\n\n        return trig_rep, sentence_vec_cat, trigger_vec_cat"
  },
  {
    "path": "model/soft_encoder.py",
    "content": "\"\"\"soft_encoder.py: Encoding sentence with LSTM.\nIt encodes sentence with Bi-LSTM.\nAfter encoding, it uses all tokens for sentence, and extract some parts for trigger.\n\nWritten in 2020 by Dong-Ho Lee.\n\"\"\"\n\nfrom config import ContextEmb\nfrom model.charbilstm import CharBiLSTM\nfrom torch.nn.utils.rnn import pack_padded_sequence, pad_packed_sequence\nimport torch.nn as nn\nimport torch\n\nclass SoftEncoder(nn.Module):\n    def __init__(self, config, encoder = None):\n        super(SoftEncoder, self).__init__()\n        self.config = config\n        self.device = config.device\n        self.use_char = config.use_char_rnn\n        self.context_emb = config.context_emb\n        self.input_size = config.embedding_dim\n\n        if self.context_emb != ContextEmb.none:\n            self.input_size += config.context_emb_size\n        if self.use_char:\n            self.char_feature = CharBiLSTM(config)\n            self.input_size += config.charlstm_hidden_dim\n\n        self.word_embedding = nn.Embedding.from_pretrained(torch.FloatTensor(config.word_embedding), freeze=False).to(self.device)\n        self.word_drop = nn.Dropout(config.dropout).to(self.device)\n        self.lstm = nn.LSTM(self.input_size, config.hidden_dim // 2, num_layers=1, batch_first=True, bidirectional=True).to(self.device)\n\n        if encoder is not None:\n            if self.use_char:\n                self.char_feature = encoder.char_feature\n            self.word_embedding = encoder.word_embedding\n            self.word_drop = encoder.word_drop\n            self.lstm = encoder.lstm\n\n\n    def forward(self, word_seq_tensor: torch.Tensor,\n                word_seq_lens: torch.Tensor,\n                batch_context_emb: torch.Tensor,\n                char_inputs: torch.Tensor,\n                char_seq_lens: torch.Tensor,\n                trigger_position):\n\n        \"\"\"\n        Get sentence and trigger encodings by Bi-LSTM\n        :param word_seq_tensor:\n        :param word_seq_lens:\n        :param batch_context_emb:\n        :param char_inputs:\n        :param char_seq_lens:\n        :param trigger_position: trigger positions in sentence (e.g. [1,4,5])\n        :return:\n        \"\"\"\n\n        # lstm_encoding\n        word_emb = self.word_embedding(word_seq_tensor)\n        if self.context_emb != ContextEmb.none:\n            word_emb = torch.cat([word_emb, batch_context_emb.to(self.device)], 2)\n        if self.use_char:\n            char_features = self.char_feature(char_inputs, char_seq_lens)\n            word_emb = torch.cat([word_emb, char_features], 2)\n        word_rep = self.word_drop(word_emb)\n        sorted_seq_len, permIdx = word_seq_lens.sort(0, descending=True)\n        _, recover_idx = permIdx.sort(0, descending=False)\n        sorted_seq_tensor = word_rep[permIdx]\n        packed_words = pack_padded_sequence(sorted_seq_tensor, sorted_seq_len.cpu(), True)\n        output, _ = self.lstm(packed_words, None)\n        output, _ = pad_packed_sequence(output, batch_first=True)\n        output = output[recover_idx]\n        sentence_mask = (word_seq_tensor != torch.tensor(0)).float()\n\n        # trigger part extraction\n        if trigger_position is not None:\n            max_length = 0\n            output_e_list = []\n            output_list = [output[i, :, :] for i in range(0, word_rep.size(0))]\n            for output_l, trigger_p in zip(output_list, trigger_position):\n                output_e = torch.stack([output_l[p, :] for p in trigger_p])\n                output_e_list.append(output_e)\n                if max_length < output_e.size(0):\n                    max_length = output_e.size(0)\n\n            trigger_vec = []\n            trigger_mask = []\n            for output_e in output_e_list:\n                trigger_vec.append(torch.cat([output_e, output_e.new_zeros(max_length - output_e.size(0), self.config.hidden_dim)], 0))\n                t_ms = []\n                for i in range(output_e.size(0)):\n                    t_ms.append(True)\n                for i in range(output_e.size(0), max_length):\n                    t_ms.append(False)\n                t_ms = torch.tensor(t_ms)\n                trigger_mask.append(t_ms)\n            trigger_vec = torch.stack(trigger_vec)\n            trigger_mask = torch.stack(trigger_mask).float()\n        else:\n            trigger_vec = None\n            trigger_mask = None\n\n        return output, sentence_mask, trigger_vec, trigger_mask\n"
  },
  {
    "path": "model/soft_inferencer.py",
    "content": "\"\"\"soft_inferencer.py: Inference on Unlabeled Sentences\ncompute the similarities between the self-attended sentence representations and the trigger representations.\nusing the most suitable triggers as additional inputs to inferencer. (CRF)\n\nWritten in 2020 by Dong-Ho Lee.\n\"\"\"\nfrom config import ContextEmb, batching_list_instances\nfrom config.eval import evaluate_batch_insts\nfrom config.utils import get_optimizer\nfrom model.linear_crf_inferencer import LinearCRF\nfrom model.soft_encoder import SoftEncoder\nimport torch\nimport torch.nn as nn\nimport torch.nn.functional as F\nfrom torch.autograd import Variable\nfrom tqdm import tqdm\nimport numpy as np\n\nclass SoftSequence(nn.Module):\n    def __init__(self, config, softmatcher, encoder=None, print_info=True):\n        super(SoftSequence, self).__init__()\n        self.config = config\n        self.device = config.device\n        self.encoder = SoftEncoder(self.config)\n        if encoder is not None:\n            self.encoder = encoder\n\n        self.softmatch_encoder = softmatcher.encoder\n        self.softmatch_attention = softmatcher.attention\n        self.label_size = config.label_size\n        self.inferencer = LinearCRF(config, print_info=print_info)\n        self.hidden2tag = nn.Linear(config.hidden_dim * 2, self.label_size).to(self.device)\n\n        self.w1 = nn.Linear(config.hidden_dim, config.hidden_dim // 2).to(self.device)\n        self.w2 = nn.Linear(config.hidden_dim // 2, config.hidden_dim // 2).to(self.device)\n        self.attn1 = nn.Linear(config.hidden_dim // 2, 1).to(self.device)\n        self.attn2 = nn.Linear(config.hidden_dim + config.hidden_dim // 2, 1).to(self.device)\n        self.attn3 = nn.Linear(config.hidden_dim // 2, 1).to(self.device)\n\n        self.applying = Variable(torch.randn(config.hidden_dim, config.hidden_dim // 2), requires_grad=True).to(self.device)\n        self.tanh = nn.Tanh().to(self.device)\n        self.perturb = nn.Dropout(config.dropout).to(self.device)\n\n\n    def forward(self, word_seq_tensor: torch.Tensor,\n                word_seq_lens: torch.Tensor,\n                batch_context_emb: torch.Tensor,\n                char_inputs: torch.Tensor,\n                char_seq_lens: torch.Tensor,\n                trigger_position, tags):\n\n        batch_size = word_seq_tensor.size(0)\n        max_sent_len = word_seq_tensor.size(1)\n\n        output, sentence_mask, trigger_vec, trigger_mask = \\\n            self.encoder(word_seq_tensor, word_seq_lens, batch_context_emb, char_inputs, char_seq_lens,\n                         trigger_position)\n\n        if trigger_vec is not None:\n            trig_rep, sentence_vec_cat, trigger_vec_cat = self.softmatch_attention(output, sentence_mask, trigger_vec, trigger_mask)\n\n            # attention\n            weights = []\n            for i in range(len(output)):\n                trig_applied = self.tanh(self.w1(output[i].unsqueeze(0)) + self.w2(trig_rep[i].unsqueeze(0).unsqueeze(0)))\n                x = self.attn1(trig_applied) #63,1\n                x = torch.mul(x.squeeze(0), sentence_mask[i].unsqueeze(1))\n                x[x==0] = float('-inf')\n                weights.append(x)\n            normalized_weights = F.softmax(torch.stack(weights), 1)\n            attn_applied1 = torch.mul(normalized_weights.repeat(1,1,output.size(2)), output)\n        else:\n            weights = []\n            for i in range(len(output)):\n                trig_applied = self.tanh(\n                    self.w1(output[i].unsqueeze(0)) + self.w1(output[i].unsqueeze(0)))\n                x = self.attn1(trig_applied)  # 63,1\n                x = torch.mul(x.squeeze(0), sentence_mask[i].unsqueeze(1))\n                x[x == 0] = float('-inf')\n                weights.append(x)\n            normalized_weights = F.softmax(torch.stack(weights), 1)\n            attn_applied1 = torch.mul(normalized_weights.repeat(1, 1, output.size(2)), output)\n\n        output = torch.cat([output, attn_applied1], dim=2)\n        lstm_scores = self.hidden2tag(output)\n        maskTemp = torch.arange(1, max_sent_len + 1, dtype=torch.long).view(1, max_sent_len).expand(batch_size,\n                                                                                                    max_sent_len).to(\n            self.device)\n        mask = torch.le(maskTemp, word_seq_lens.view(batch_size, 1).expand(batch_size, max_sent_len)).to(self.device)\n\n        if self.inferencer is not None:\n            unlabeled_score, labeled_score = self.inferencer(lstm_scores, word_seq_lens, tags, mask)\n            sequence_loss = unlabeled_score - labeled_score\n        else:\n            sequence_loss = self.compute_nll_loss(lstm_scores, tags, mask, word_seq_lens)\n\n        return sequence_loss\n\n\n    def decode(self, word_seq_tensor: torch.Tensor,\n               word_seq_lens: torch.Tensor,\n               batch_context_emb: torch.Tensor,\n               char_inputs: torch.Tensor,\n               char_seq_lens: torch.Tensor,\n               trig_rep):\n\n        output, sentence_mask, _, _ = \\\n            self.encoder(word_seq_tensor, word_seq_lens, batch_context_emb, char_inputs, char_seq_lens, None)\n\n        soft_output, soft_sentence_mask, _, _ = \\\n            self.softmatch_encoder(word_seq_tensor, word_seq_lens, batch_context_emb, char_inputs, char_seq_lens, None)\n        soft_sent_rep = self.softmatch_attention.attention(soft_output, soft_sentence_mask)\n\n        trig_vec = trig_rep[0]\n        trig_key = trig_rep[1]\n\n        n = soft_sent_rep.size(0)\n        m = trig_vec.size(0)\n        d = soft_sent_rep.size(1)\n\n        soft_sent_rep_dist = soft_sent_rep.unsqueeze(1).expand(n, m, d)\n        trig_vec_dist = trig_vec.unsqueeze(0).expand(n, m, d)\n\n        dist = torch.pow(soft_sent_rep_dist-trig_vec_dist, 2).sum(2).sqrt()\n        dvalue, dindices = torch.min(dist, dim=1)\n\n        trigger_list = []\n        for i in dindices.tolist():\n            trigger_list.append(trig_vec[i])\n        trig_rep = torch.stack(trigger_list)\n\n        # attention\n        weights = []\n        for i in range(len(output)):\n            trig_applied = self.tanh(self.w1(output[i].unsqueeze(0)) + self.w2(trig_rep[i].unsqueeze(0).unsqueeze(0)))\n            x = self.attn1(trig_applied)\n            x = torch.mul(x.squeeze(0), sentence_mask[i].unsqueeze(1))\n            x[x == 0] = float('-inf')\n            weights.append(x)\n        normalized_weights = F.softmax(torch.stack(weights), 1)\n        attn_applied1 = torch.mul(normalized_weights.repeat(1, 1, output.size(2)), output)\n\n\n        output = torch.cat([output, attn_applied1], dim=2)\n\n        lstm_scores = self.hidden2tag(output)\n        bestScores, decodeIdx = self.inferencer.decode(lstm_scores, word_seq_lens, None)\n\n        return bestScores, decodeIdx\n\n\nclass SoftSequenceTrainer(object):\n    def __init__(self, model, config, dev, test, triggers):\n        self.model = model\n        self.config = config\n        self.device = config.device\n        self.input_size = config.embedding_dim\n        self.context_emb = config.context_emb\n        self.use_char = config.use_char_rnn\n        self.triggers = triggers\n        if self.context_emb != ContextEmb.none:\n            self.input_size += config.context_emb_size\n        if self.use_char:\n            self.input_size += config.charlstm_hidden_dim\n        self.dev = dev\n        self.test = test\n\n\n    def train_model(self, num_epochs, train_data, eval):\n        batched_data = batching_list_instances(self.config, train_data)\n        self.optimizer = get_optimizer(self.config, self.model, 'sgd')\n        for epoch in range(num_epochs):\n            epoch_loss = 0\n            self.model.zero_grad()\n            for index in tqdm(np.random.permutation(len(batched_data))):\n                self.model.train()\n                sequence_loss = self.model(*batched_data[index][0:5], batched_data[index][-2], batched_data[index][-3])\n                loss = sequence_loss\n                epoch_loss = epoch_loss + loss.data\n                loss.backward(retain_graph=True)\n                self.optimizer.step()\n                self.model.zero_grad()\n            print(epoch_loss)\n            if eval:\n                self.model.eval()\n                dev_batches = batching_list_instances(self.config, self.dev)\n                test_batches = batching_list_instances(self.config, self.test)\n                dev_metrics = self.evaluate_model(dev_batches, \"dev\", self.dev, self.triggers)\n                test_metrics = self.evaluate_model(test_batches, \"test\", self.test, self.triggers)\n                self.model.zero_grad()\n        return self.model\n\n\n    def self_training(self, num_epochs, train_data, unlabeled_data):\n        self.optimizer = get_optimizer(self.config, self.model, 'sgd')\n        merged_data = train_data\n        unlabels = unlabeled_data\n        for epoch in range(num_epochs):\n            batched_data = batching_list_instances(self.config, merged_data)\n            epoch_loss = 0\n            self.model.zero_grad()\n            for index in tqdm(np.random.permutation(len(batched_data))):\n                self.model.train()\n                sequence_loss = self.model(*batched_data[index][0:5], batched_data[index][-2], batched_data[index][-3])\n                loss = sequence_loss\n                epoch_loss = epoch_loss + loss.data\n                loss.backward(retain_graph=True)\n                self.optimizer.step()\n                self.model.zero_grad()\n            print(epoch_loss)\n\n            self.model.eval()\n            dev_batches = batching_list_instances(self.config, self.dev)\n            test_batches = batching_list_instances(self.config, self.test)\n            dev_metrics = self.evaluate_model(dev_batches, \"dev\", self.dev, self.triggers)\n            test_metrics = self.evaluate_model(test_batches, \"test\", self.test, self.triggers)\n            self.model.zero_grad()\n\n            weaklabel, unlabel = self.weak_label_selftrain(unlabels, self.triggers)\n            merged_data = merged_data + weaklabel\n            unlabels = unlabel\n            print(len(merged_data), len(weaklabel), len(unlabels))\n        return self.model\n\n\n    def evaluate_model(self, batch_insts_ids, name: str, insts, triggers):\n        ## evaluation\n        metrics = np.asarray([0, 0, 0], dtype=int)\n        batch_id = 0\n        batch_size = self.config.batch_size\n        for batch in batch_insts_ids:\n            one_batch_insts = insts[batch_id * batch_size:(batch_id + 1) * batch_size]\n            batch_max_scores, batch_max_ids = self.model.decode(*batch[0:5], triggers)\n            metrics += evaluate_batch_insts(one_batch_insts, batch_max_ids, batch[6], batch[1], self.config.idx2labels,\n                                            self.config.use_crf_layer)\n            batch_id += 1\n        p, total_predict, total_entity = metrics[0], metrics[1], metrics[2]\n        precision = p * 1.0 / total_predict * 100 if total_predict != 0 else 0\n        recall = p * 1.0 / total_entity * 100 if total_entity != 0 else 0\n        fscore = 2.0 * precision * recall / (precision + recall) if precision != 0 or recall != 0 else 0\n        print(\"[%s set] Precision: %.2f, Recall: %.2f, F1: %.2f\" % (name, precision, recall, fscore), flush=True)\n        return [precision, recall, fscore]\n\n\n    def weakly_labeling(self, batch_insts_ids, insts, triggers):\n        batch_id = 0\n        batch_size = self.config.batch_size\n        matched = []\n        matched_scores = []\n        matched_sentences = 0\n        unlabeled = []\n        for batch in batch_insts_ids:\n            one_batch_insts = insts[batch_id * batch_size:(batch_id + 1) * batch_size]\n            batch_max_scores, batch_max_ids = self.model.decode(*batch[0:5], triggers)\n            match_indices = (torch.sum(batch_max_ids, dim=1) > 0).nonzero().squeeze(1).tolist()\n            unmatch_indices = (torch.sum(batch_max_ids, dim=1) == 0).nonzero().squeeze(1).tolist()\n            matched_sentences += len(match_indices)\n            word_seq_lens = batch[1].cpu().numpy()\n            for idx in match_indices:\n                length = word_seq_lens[idx]\n                prediction = batch_max_ids[idx][:length].tolist()\n                prediction = prediction[::-1]\n                is_match = False\n                for pred in prediction:\n                    if pred != self.config.label2idx['O']:\n                        one_batch_insts[idx].output_ids = prediction\n                        one_batch_insts[idx].trigger_label = -1\n                        one_batch_insts[idx].trigger_positions = [i for i in range(0, len(prediction))]\n                        matched.append(one_batch_insts[idx])\n                        matched_scores.append(batch_max_scores[idx])\n                        is_match = True\n                        break\n                if is_match == False:\n                    unlabeled.append(one_batch_insts[idx])\n            for idx in unmatch_indices:\n                unlabeled.append(one_batch_insts[idx])\n            batch_id += 1\n        return matched, unlabeled, matched_scores\n\n\n    def weak_label_selftrain(self, unlabeled_data, triggers):\n        batched_data = batching_list_instances(self.config, unlabeled_data, is_soft=False, is_naive=True)\n        weakly_labeled, unlabeled, confidence = self.weakly_labeling(batched_data, unlabeled_data, triggers)\n\n        confidence_order = [i[0] for i in sorted(enumerate(confidence), key=lambda x: x[1])]\n        threshold = int(len(confidence_order) * 0.01)\n        high_confidence = confidence_order[:threshold]\n        low_confidence = confidence_order[threshold:]\n\n        final_weakly_labeled = [weakly_labeled[i] for i in high_confidence]\n        unlabeled = unlabeled + [weakly_labeled[i] for i in low_confidence]\n\n        return final_weakly_labeled, unlabeled"
  },
  {
    "path": "model/soft_inferencer_naive.py",
    "content": "\"\"\"soft_inferencer_navie.py: Inference on Unlabeled Sentences (without trigger - baseline setting)\nBaseline setting inference. (normal BLSTM-CRF.)\n\nWritten in 2020 by Dong-Ho Lee.\n\"\"\"\nfrom config import ContextEmb, batching_list_instances\nfrom config.utils import get_optimizer\nfrom config.eval import evaluate_batch_insts\nimport torch\nimport torch.nn as nn\nfrom model.linear_crf_inferencer import LinearCRF\nfrom model.soft_encoder import SoftEncoder\nfrom tqdm import tqdm\nimport numpy as np\n\nclass SoftSequenceNaive(nn.Module):\n    def __init__(self, config,  encoder=None, print_info=True):\n        super(SoftSequenceNaive, self).__init__()\n        self.config = config\n        self.device = config.device\n\n        self.encoder = SoftEncoder(self.config)\n        if encoder is not None:\n            self.encoder = encoder\n\n        self.label_size = config.label_size\n        self.inferencer = LinearCRF(config, print_info=print_info)\n        self.hidden2tag = nn.Linear(config.hidden_dim, self.label_size).to(self.device)\n\n    def forward(self, word_seq_tensor: torch.Tensor,\n                word_seq_lens: torch.Tensor,\n                batch_context_emb: torch.Tensor,\n                char_inputs: torch.Tensor,\n                char_seq_lens: torch.Tensor, tags):\n\n        batch_size = word_seq_tensor.size(0)\n        max_sent_len = word_seq_tensor.size(1)\n\n        output, sentence_mask, _, _ = \\\n            self.encoder(word_seq_tensor, word_seq_lens, batch_context_emb, char_inputs, char_seq_lens, None)\n\n        lstm_scores = self.hidden2tag(output)\n        maskTemp = torch.arange(1, max_sent_len + 1, dtype=torch.long).view(1, max_sent_len).expand(batch_size, max_sent_len).to(self.device)\n        mask = torch.le(maskTemp, word_seq_lens.view(batch_size, 1).expand(batch_size, max_sent_len)).to(self.device)\n\n        if self.inferencer is not None:\n            unlabeled_score, labeled_score = self.inferencer(lstm_scores, word_seq_lens, tags, mask)\n            sequence_loss = unlabeled_score - labeled_score\n        else:\n            sequence_loss = self.compute_nll_loss(lstm_scores, tags, mask, word_seq_lens)\n\n        return sequence_loss\n\n    def decode(self, word_seq_tensor: torch.Tensor,\n                word_seq_lens: torch.Tensor,\n                batch_context_emb: torch.Tensor,\n                char_inputs: torch.Tensor,\n                char_seq_lens: torch.Tensor):\n\n        soft_output, soft_sentence_mask, _, _ = \\\n                    self.encoder(word_seq_tensor, word_seq_lens, batch_context_emb, char_inputs, char_seq_lens, None)\n        lstm_scores = self.hidden2tag(soft_output)\n        if self.inferencer is not None:\n            bestScores, decodeIdx = self.inferencer.decode(lstm_scores, word_seq_lens, None)\n        return bestScores, decodeIdx\n\n\nclass SoftSequenceNaiveTrainer(object):\n    def __init__(self, model, config, dev, test):\n        self.model = model\n        self.config = config\n        self.device = config.device\n        self.input_size = config.embedding_dim\n        self.context_emb = config.context_emb\n        self.use_char = config.use_char_rnn\n        if self.context_emb != ContextEmb.none:\n            self.input_size += config.context_emb_size\n        if self.use_char:\n            self.input_size += config.charlstm_hidden_dim\n        self.dev = dev\n        self.test = test\n\n    def train_model(self, num_epochs, train_data):\n        batched_data = batching_list_instances(self.config, train_data)\n        self.optimizer = get_optimizer(self.config, self.model, self.config.optimizer)\n        for epoch in range(num_epochs):\n            epoch_loss = 0\n            self.model.zero_grad()\n            for index in tqdm(np.random.permutation(len(batched_data))):\n                self.model.train()\n                sequence_loss = self.model(*batched_data[index][0:5], batched_data[index][-3])\n                loss = sequence_loss\n                epoch_loss = epoch_loss + loss.data\n                loss.backward(retain_graph=True)\n                self.optimizer.step()\n                self.model.zero_grad()\n            print(epoch_loss)\n\n            self.model.eval()\n\n            dev_batches = batching_list_instances(self.config, self.dev)\n            test_batches = batching_list_instances(self.config, self.test)\n            dev_metrics = self.evaluate_model(dev_batches, \"dev\", self.dev)\n            test_metrics = self.evaluate_model(test_batches, \"test\", self.test)\n            self.model.zero_grad()\n        return self.model\n\n    def evaluate_model(self, batch_insts_ids, name: str, insts):\n        ## evaluation\n        metrics = np.asarray([0, 0, 0], dtype=int)\n        batch_id = 0\n        batch_size = self.config.batch_size\n        for batch in batch_insts_ids:\n            one_batch_insts = insts[batch_id * batch_size:(batch_id + 1) * batch_size]\n            batch_max_scores, batch_max_ids = self.model.decode(*batch[0:5])\n            metrics += evaluate_batch_insts(one_batch_insts, batch_max_ids, batch[6], batch[1], self.config.idx2labels,\n                                            self.config.use_crf_layer)\n            batch_id += 1\n        p, total_predict, total_entity = metrics[0], metrics[1], metrics[2]\n        precision = p * 1.0 / total_predict * 100 if total_predict != 0 else 0\n        recall = p * 1.0 / total_entity * 100 if total_entity != 0 else 0\n        fscore = 2.0 * precision * recall / (precision + recall) if precision != 0 or recall != 0 else 0\n        print(\"[%s set] Precision: %.2f, Recall: %.2f, F1: %.2f\" % (name, precision, recall, fscore), flush=True)\n        return [precision, recall, fscore]\n\n\n"
  },
  {
    "path": "model/soft_matcher.py",
    "content": "\"\"\"soft_matcher.py: Joint training between trigger encoder and trigger matcher\nIt jointly trains the trigger encoder and trigger matcher\n\ntrigger encoder -> classification of trigger representation from encoder / attention\ntrigger matcher -> contrastive loss of sentence representation and trigger representation from encoder / attention\n\nWritten in 2020 by Dong-Ho Lee.\n\"\"\"\n\nfrom config import ContextEmb, batching_list_instances\nfrom config.utils import get_optimizer\nimport torch\nimport torch.nn as nn\nimport torch.nn.functional as F\nfrom model.soft_encoder import SoftEncoder\nfrom model.soft_attention import SoftAttention\nfrom sklearn.metrics import accuracy_score\nfrom tqdm import tqdm\nimport numpy as np\n\nclass ContrastiveLoss(nn.Module):\n    def __init__(self, margin, device):\n        super(ContrastiveLoss, self).__init__()\n        self.margin = margin\n        self.eps = 1e-9\n        self.device = device\n\n    def forward(self, output1, output2, target, size_average=True):\n        target = target.to(self.device)\n        distances = (output2 - output1).pow(2).sum(1).to(self.device)  # squared distances\n        losses = 0.5 * (target.float() * distances +\n                        (1 + -1 * target).float() * F.relu(self.margin - (distances + self.eps).sqrt()).pow(2))\n        return losses.mean() if size_average else losses.sum()\n\n\nclass SoftMatcher(nn.Module):\n    def __init__(self, config, num_classes):\n        super(SoftMatcher, self).__init__()\n        self.config = config\n        self.device = config.device\n\n        self.encoder = SoftEncoder(self.config)\n        self.attention = SoftAttention(self.config)\n\n        # final calssification layers\n        self.trigger_type_layer = nn.Linear(config.hidden_dim // 2, num_classes).to(self.device)\n\n    def forward(self, word_seq_tensor: torch.Tensor,\n                word_seq_lens: torch.Tensor,\n                batch_context_emb: torch.Tensor,\n                char_inputs: torch.Tensor,\n                char_seq_lens: torch.Tensor,\n                trigger_position):\n\n        output, sentence_mask, trigger_vec, trigger_mask = \\\n            self.encoder(word_seq_tensor, word_seq_lens, batch_context_emb, char_inputs, char_seq_lens, trigger_position)\n        trig_rep, sentence_vec_cat, trigger_vec_cat = self.attention(output, sentence_mask, trigger_vec, trigger_mask)\n        final_trigger_type = self.trigger_type_layer(trig_rep)\n        return trig_rep, F.log_softmax(final_trigger_type, dim=1), sentence_vec_cat, trigger_vec_cat\n\n\nclass SoftMatcherTrainer(object):\n    def __init__(self, model, config, dev, test):\n        self.model = model\n        self.config = config\n        self.device = config.device\n        self.input_size = config.embedding_dim\n        self.context_emb = config.context_emb\n        self.use_char = config.use_char_rnn\n        if self.context_emb != ContextEmb.none:\n            self.input_size += config.context_emb_size\n        if self.use_char:\n            self.input_size += config.charlstm_hidden_dim\n        self.contrastive_loss = ContrastiveLoss(1.0, self.device)\n        self.dev = dev\n        self.test = test\n\n    def train_model(self, num_epochs, train_data):\n        batched_data = batching_list_instances(self.config, train_data)\n        self.optimizer = get_optimizer(self.config, self.model, 'adam')\n        criterion = nn.NLLLoss()\n        for epoch in range(num_epochs):\n            epoch_loss = 0\n            self.model.zero_grad()\n            for index in tqdm(np.random.permutation(len(batched_data))):\n                self.model.train()\n                trig_rep, trig_type_probas, match_trig, match_sent = self.model(*batched_data[index][0:5], batched_data[index][-2])\n                trigger_loss = criterion(trig_type_probas, batched_data[index][-1])\n                soft_matching_loss = self.contrastive_loss(match_trig, match_sent, torch.stack([torch.tensor(1)]*trig_rep.size(0) + [torch.tensor(0)]*trig_rep.size(0)))\n                loss = trigger_loss + soft_matching_loss\n                epoch_loss = epoch_loss + loss.data\n                loss.backward(retain_graph=True)\n                self.optimizer.step()\n                self.model.zero_grad()\n            print(epoch_loss)\n            self.test_model(train_data)\n            self.model.zero_grad()\n\n        return self.model\n\n\n    def test_model(self, test_data):\n        batched_data = batching_list_instances(self.config, test_data)\n        self.model.eval()\n        predicted_list = []\n        target_list = []\n        match_target_list = []\n        matched_list = []\n        for index in tqdm(np.random.permutation(len(batched_data))):\n            trig_rep, trig_type_probas, match_trig, match_sent = self.model(*batched_data[index][0:5], batched_data[index][-2])\n            trig_type_value, trig_type_predicted = torch.max(trig_type_probas, 1)\n            target = batched_data[index][-1]\n            target_list.extend(target.tolist())\n            predicted_list.extend(trig_type_predicted.tolist())\n\n            match_target_list.extend([torch.tensor(1)]*trig_rep.size(0) + [torch.tensor(0)]*trig_rep.size(0))\n            distances = (match_trig - match_sent).pow(2).sum(1)\n            distances = torch.sqrt(distances)\n            matched_list.extend((distances < 1.0).long().tolist())\n\n        print(\"trigger classification accuracy \", accuracy_score(predicted_list, target_list))\n        print(\"soft matching accuracy \", accuracy_score(matched_list, match_target_list))\n\n\n    def get_triggervec(self, data):\n        batched_data = batching_list_instances(self.config, data)\n        self.model.eval()\n        logits_list = []\n        predicted_list = []\n        trigger_list = []\n        for index in tqdm(range(len(batched_data))):\n            trig_rep, trig_type_probas, match_trig, match_sent = self.model(*batched_data[index][0:5], batched_data[index][-2])\n            trig_type_value, trig_type_predicted = torch.max(trig_type_probas, 1)\n            ne_batch_insts = data[index * self.config.batch_size:(index + 1) * self.config.batch_size]\n            for idx in range(len(trig_rep)):\n                ne_batch_insts[idx].trigger_vec = trig_rep[idx]\n            logits_list.extend(trig_rep)\n            predicted_list.extend(trig_type_predicted)\n            word_seq = batched_data[index][0]\n            trigger_positions = batched_data[index][-2]\n\n            for ws, tp in zip(word_seq, trigger_positions):\n                trigger_list.append(\" \".join(self.config.idx2word[ws[index]] for index in tp))\n\n        return logits_list, predicted_list, trigger_list\n"
  },
  {
    "path": "naive.py",
    "content": "\"\"\"naive.py: Testing baselines\n\nbaseline setting (Bi-LSTM / CRF)\nuse percentage argument to reproduce the results (20 %)\n\nWritten in 2020 by Dong-Ho Lee.\n\"\"\"\nfrom model.soft_inferencer_naive import *\nfrom config import Reader, Config, ContextEmb\nfrom config.utils import load_bert_vec\nimport argparse, random\n\ndef parse_arguments(parser):\n    parser.add_argument('--device', type=str, default=\"cpu\", choices=['cpu', 'cuda:0', 'cuda:1', 'cuda:2','cuda:3', 'cuda:4', 'cuda:5', 'cuda:6'],\n                        help=\"GPU/CPU devices\")\n    parser.add_argument('--seed', type=int, default=42, help=\"random seed\")\n    parser.add_argument('--digit2zero', action=\"store_true\", default=True,\n                        help=\"convert the number to 0, make it true is better\")\n    parser.add_argument('--dataset', type=str, default=\"CONLL\")\n    parser.add_argument('--embedding_file', type=str, default=\"dataset/glove.6B.100d.txt\",\n                        help=\"we will using random embeddings if file do not exist\")\n    parser.add_argument('--embedding_dim', type=int, default=100)\n    parser.add_argument('--optimizer', type=str, default=\"sgd\")\n    parser.add_argument('--learning_rate', type=float, default=0.01)\n    parser.add_argument('--momentum', type=float, default=0.0)\n    parser.add_argument('--l2', type=float, default=1e-8)\n    parser.add_argument('--lr_decay', type=float, default=0)\n    parser.add_argument('--batch_size', type=int, default=10, help=\"default batch size is 10 (works well)\")\n    parser.add_argument('--num_epochs', type=int, default=10, help=\"Usually we set to 10.\")\n    parser.add_argument('--num_epochs_soft', type=int, default=20, help=\"Usually we set to 20.\")\n    parser.add_argument('--train_num', type=int, default=-1, help=\"-1 means all the data\")\n    parser.add_argument('--dev_num', type=int, default=-1, help=\"-1 means all the data\")\n    parser.add_argument('--test_num', type=int, default=-1, help=\"-1 means all the data\")\n    parser.add_argument('--trig_optimizer', type=str, default=\"adam\")\n\n    ##model hyperparameter\n    parser.add_argument('--model_folder', type=str, default=\"english_model\", help=\"The name to save the model files\")\n    parser.add_argument('--hidden_dim', type=int, default=200, help=\"hidden size of the LSTM\")\n    parser.add_argument('--use_crf_layer', type=int, default=1, help=\"1 is for using crf layer, 0 for not using CRF layer\", choices=[0,1])\n    parser.add_argument('--dropout', type=float, default=0.5, help=\"dropout for embedding\")\n    parser.add_argument('--use_char_rnn', type=int, default=1, choices=[0, 1], help=\"use character-level lstm, 0 or 1\")\n    parser.add_argument('--context_emb', type=str, default=\"none\", choices=[\"none\", \"elmo\", \"bert\"], help=\"contextual word embedding\")\n    parser.add_argument('--ds_setting', nargs='+', help=\"+ hard / soft matching\") # soft, hard\n    parser.add_argument('--percentage', type=int, default=100, help=\"how much percentage of training dataset to use\")\n\n    args = parser.parse_args()\n    for k in args.__dict__:\n        print(k + \": \" + str(args.__dict__[k]))\n    return args\n\n\nparser = argparse.ArgumentParser()\nopt = parse_arguments(parser)\nconf = Config(opt)\nreader = Reader(conf.digit2zero)\ndataset = reader.read_txt(conf.train_file, conf.dev_num)\ndevs = reader.read_txt(conf.dev_file, conf.dev_num)\ntests = reader.read_txt(conf.test_file, conf.test_num)\nprint(len(dataset))\nif conf.context_emb == ContextEmb.bert:\n    print('Loading the BERT vectors for all datasets.')\n    conf.context_emb_size = load_bert_vec(conf.trigger_file + \".\" + conf.context_emb.name + \".vec\", dataset)\n\n# setting for data\nconf.use_iobes(dataset)\nconf.use_iobes(devs)\nconf.use_iobes(tests)\n\nconf.build_label_idx(dataset)\nconf.build_word_idx(dataset, devs, tests)\nconf.build_emb_table()\nconf.map_insts_ids(dataset)\nconf.map_insts_ids(devs)\nconf.map_insts_ids(tests)\n\n# dataset division\nnumbers = int(len(dataset) * conf.percentage / 100)\ninitial_trains = dataset[:numbers]\nrandom.shuffle(initial_trains)\n\nencoder = SoftSequenceNaive(conf)\ntrainer = SoftSequenceNaiveTrainer(encoder, conf, devs, tests)\ntrainer.train_model(conf.num_epochs, initial_trains)\n\n\n"
  },
  {
    "path": "requirments.txt",
    "content": "torch >= 0.4.1\nnumpy\noverrides == 2.0\ntqdm\ntermcolor\nsklearn\nmatplotlib\npytorch_pretrained_bert\n"
  },
  {
    "path": "semi_supervised.py",
    "content": "\"\"\"semi_supervised.py: semi_supervised learning with triggers (self training)\n\nusing 20% of the train data w/ triggers (already in trigger_20.txt file in each dataset),\nand rest 80% of train data as unlabeled dataset.\n\nWritten in 2020 by Dong-Ho Lee.\n\"\"\"\nfrom model.soft_matcher import *\nfrom model.soft_inferencer import *\nfrom model.soft_inferencer_naive import SoftSequenceNaive\nfrom config import Reader, Config, ContextEmb\nfrom config.utils import load_bert_vec, get_optimizer, lr_decay\nfrom config.eval import evaluate_batch_insts\nfrom util import remove_duplicates\nfrom typing import List\nfrom tqdm import tqdm\nfrom common import Sentence, Instance\nimport argparse, os, time, random\nimport numpy as np\n\ndef parse_arguments(parser):\n    ###Training Hyperparameters\n    parser.add_argument('--device', type=str, default=\"cpu\", choices=['cpu', 'cuda:0', 'cuda:1', 'cuda:2','cuda:3', 'cuda:4', 'cuda:5', 'cuda:6'],\n                        help=\"GPU/CPU devices\")\n    parser.add_argument('--seed', type=int, default=42, help=\"random seed\")\n    parser.add_argument('--digit2zero', action=\"store_true\", default=True,\n                        help=\"convert the number to 0, make it true is better\")\n    parser.add_argument('--dataset', type=str, default=\"CONLL\")\n    parser.add_argument('--embedding_file', type=str, default=\"dataset/glove.6B.100d.txt\",\n                        help=\"we will using random embeddings if file do not exist\")\n    parser.add_argument('--embedding_dim', type=int, default=100)\n    parser.add_argument('--optimizer', type=str, default=\"sgd\")\n    parser.add_argument('--learning_rate', type=float, default=0.01)\n    parser.add_argument('--momentum', type=float, default=0.0)\n    parser.add_argument('--l2', type=float, default=1e-8)\n    parser.add_argument('--lr_decay', type=float, default=0)\n    parser.add_argument('--batch_size', type=int, default=10, help=\"default batch size is 10 (works well)\")\n    parser.add_argument('--num_epochs', type=int, default=10, help=\"Usually we set to 10.\")\n    parser.add_argument('--num_epochs_soft', type=int, default=20, help=\"Usually we set to 20.\")\n    parser.add_argument('--train_num', type=int, default=-1, help=\"-1 means all the data\")\n    parser.add_argument('--dev_num', type=int, default=-1, help=\"-1 means all the data\")\n    parser.add_argument('--test_num', type=int, default=-1, help=\"-1 means all the data\")\n    parser.add_argument('--trig_optimizer', type=str, default=\"adam\")\n\n    ##model hyperparameter\n    parser.add_argument('--model_folder', type=str, default=\"english_model\", help=\"The name to save the model files\")\n    parser.add_argument('--hidden_dim', type=int, default=200, help=\"hidden size of the LSTM\")\n    parser.add_argument('--use_crf_layer', type=int, default=1, help=\"1 is for using crf layer, 0 for not using CRF layer\", choices=[0,1])\n    parser.add_argument('--dropout', type=float, default=0.5, help=\"dropout for embedding\")\n    parser.add_argument('--use_char_rnn', type=int, default=1, choices=[0, 1], help=\"use character-level lstm, 0 or 1\")\n    parser.add_argument('--context_emb', type=str, default=\"none\", choices=[\"none\", \"elmo\", \"bert\"], help=\"contextual word embedding\")\n    parser.add_argument('--ds_setting', nargs='+', help=\"+ hard / soft matching\") # soft, hard\n    parser.add_argument('--percentage', type=int, default=100, help=\"how much percentage of training dataset to use\")\n    parser.add_argument('--unlabeled_percentage', type=float, default=0.8, help=\"how much percentage of training dataset to be used for unlabeld data\")\n\n    args = parser.parse_args()\n    for k in args.__dict__:\n        print(k + \": \" + str(args.__dict__[k]))\n    return args\n\ndef main():\n    parser = argparse.ArgumentParser()\n    opt = parse_arguments(parser)\n    conf = Config(opt)\n    reader = Reader(conf.digit2zero)\n    dataset, max_length, label_length = reader.read_trigger_txt(conf.trigger_file, -1)\n\n    reader.merge_labels(dataset)\n\n    trains = reader.read_txt(conf.train_all_file, conf.train_num)\n    devs = reader.read_txt(conf.dev_file, conf.dev_num)\n    tests = reader.read_txt(conf.test_file, conf.test_num)\n    print(len(dataset))\n    if conf.context_emb == ContextEmb.bert:\n        print('Loading the BERT vectors for all datasets.')\n        conf.context_emb_size = load_bert_vec(conf.trigger_file + \".\" + conf.context_emb.name + \".vec\", dataset)\n\n    # setting for data\n    conf.use_iobes(trains)\n    conf.use_iobes(dataset)\n    conf.use_iobes(devs)\n    conf.use_iobes(tests)\n\n    conf.optimizer = opt.trig_optimizer\n    conf.build_label_idx(dataset)\n    conf.build_word_idx(trains, devs, tests)\n    conf.build_emb_table()\n    conf.map_insts_ids(dataset)\n    conf.map_insts_ids(trains)\n    conf.map_insts_ids(devs)\n    conf.map_insts_ids(tests)\n\n    dataset = reader.trigger_percentage(dataset, conf.percentage)\n    encoder = SoftMatcher(conf, label_length)\n    trainer = SoftMatcherTrainer(encoder, conf, devs, tests)\n\n    # matching module training\n    random.shuffle(dataset)\n    trainer.train_model(conf.num_epochs_soft, dataset)\n    logits, predicted, triggers = trainer.get_triggervec(dataset)\n    # all the trigger vectors, trigger type, string name of the trigger\n    triggers_remove = remove_duplicates(logits, predicted, triggers, dataset)\n\n    numbers = int(len(trains) * (1 - opt.unlabeled_percentage))\n    print(\"number of train instances : \", numbers)\n    initial_trains = trains[:numbers]\n    unlabeled_x = trains[numbers:]\n\n    for data in unlabeled_x:\n        data.output_ids = None\n\n    # sequence labeling module self-training\n    random.shuffle(dataset)\n    inference = SoftSequence(conf, encoder)\n    sequence_trainer = SoftSequenceTrainer(inference, conf, devs, tests, triggers_remove)\n    sequence_trainer.self_training(conf.num_epochs, dataset, unlabeled_x)\n\nif __name__ == \"__main__\":\n    main()\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n"
  },
  {
    "path": "supervised.py",
    "content": "\"\"\"supervised.py: supervised learning with triggers\n\nusing 20% of the train data w/ triggers (already in trigger_20.txt file in each dataset)\n\nWritten in 2020 by Dong-Ho Lee.\n\"\"\"\nfrom model.soft_matcher import *\nfrom model.soft_inferencer import *\nfrom config import Reader, Config, ContextEmb\nfrom config.utils import load_bert_vec\nimport argparse\nimport random\nfrom util import remove_duplicates\n\ndef parse_arguments(parser):\n    parser.add_argument('--device', type=str, default=\"cpu\", choices=['cpu', 'cuda:0', 'cuda:1', 'cuda:2','cuda:3', 'cuda:4', 'cuda:5', 'cuda:6'],\n                        help=\"GPU/CPU devices\")\n    parser.add_argument('--seed', type=int, default=42, help=\"random seed\")\n    parser.add_argument('--digit2zero', action=\"store_true\", default=True,\n                        help=\"convert the number to 0, make it true is better\")\n    parser.add_argument('--dataset', type=str, default=\"CONLL\")\n    parser.add_argument('--embedding_file', type=str, default=\"dataset/glove.6B.100d.txt\",\n                        help=\"we will using random embeddings if file do not exist\")\n    parser.add_argument('--embedding_dim', type=int, default=100)\n    parser.add_argument('--optimizer', type=str, default=\"sgd\")\n    parser.add_argument('--learning_rate', type=float, default=0.01)\n    parser.add_argument('--momentum', type=float, default=0.0)\n    parser.add_argument('--l2', type=float, default=1e-8)\n    parser.add_argument('--lr_decay', type=float, default=0)\n    parser.add_argument('--batch_size', type=int, default=10, help=\"default batch size is 10 (works well)\")\n    parser.add_argument('--num_epochs', type=int, default=10, help=\"Usually we set to 10.\")\n    parser.add_argument('--num_epochs_soft', type=int, default=20, help=\"Usually we set to 20.\")\n    parser.add_argument('--train_num', type=int, default=-1, help=\"-1 means all the data\")\n    parser.add_argument('--dev_num', type=int, default=-1, help=\"-1 means all the data\")\n    parser.add_argument('--test_num', type=int, default=-1, help=\"-1 means all the data\")\n    parser.add_argument('--trig_optimizer', type=str, default=\"adam\")\n\n    ##model hyperparameter\n    parser.add_argument('--model_folder', type=str, default=\"english_model\", help=\"The name to save the model files\")\n    parser.add_argument('--hidden_dim', type=int, default=200, help=\"hidden size of the LSTM\")\n    parser.add_argument('--use_crf_layer', type=int, default=1, help=\"1 is for using crf layer, 0 for not using CRF layer\", choices=[0,1])\n    parser.add_argument('--dropout', type=float, default=0.5, help=\"dropout for embedding\")\n    parser.add_argument('--use_char_rnn', type=int, default=1, choices=[0, 1], help=\"use character-level lstm, 0 or 1\")\n    parser.add_argument('--context_emb', type=str, default=\"none\", choices=[\"none\", \"elmo\", \"bert\"], help=\"contextual word embedding\")\n    parser.add_argument('--ds_setting', nargs='+', help=\"+ hard / soft matching\") # soft, hard\n    parser.add_argument('--percentage', type=int, default=100, help=\"how much percentage of training dataset to use\")\n\n    args = parser.parse_args()\n    for k in args.__dict__:\n        print(k + \": \" + str(args.__dict__[k]))\n    return args\n\n\nparser = argparse.ArgumentParser()\nopt = parse_arguments(parser)\nconf = Config(opt)\nreader = Reader(conf.digit2zero)\ndataset, max_length, label_length = reader.read_trigger_txt(conf.trigger_file, -1)\nreader.merge_labels(dataset)\n\ndevs = reader.read_txt(conf.dev_file, conf.dev_num)\ntests = reader.read_txt(conf.test_file, conf.test_num)\nprint(len(dataset))\nif conf.context_emb == ContextEmb.bert:\n    print('Loading the BERT vectors for all datasets.')\n    conf.context_emb_size = load_bert_vec(conf.trigger_file + \".\" + conf.context_emb.name + \".vec\", dataset)\n\n\n# setting for data\nconf.use_iobes(dataset)\nconf.use_iobes(devs)\nconf.use_iobes(tests)\n\nconf.optimizer = opt.trig_optimizer\nconf.build_label_idx(dataset)\nconf.build_word_idx(dataset, devs, tests)\nconf.build_emb_table()\nconf.map_insts_ids(dataset)\nconf.map_insts_ids(devs)\nconf.map_insts_ids(tests)\n\ndataset = reader.trigger_percentage(dataset, conf.percentage)\nencoder = SoftMatcher(conf, label_length)\ntrainer = SoftMatcherTrainer(encoder, conf, devs, tests)\n\n# matching module training\nrandom.shuffle(dataset)\ntrainer.train_model(conf.num_epochs_soft, dataset)\nlogits, predicted, triggers = trainer.get_triggervec(dataset)\ntriggers_remove = remove_duplicates(logits, predicted, triggers, dataset)\n\n# sequence labeling module training\nrandom.shuffle(dataset)\ninference = SoftSequence(conf, encoder)\nsequence_trainer = SoftSequenceTrainer(inference, conf, devs, tests, triggers_remove)\nsequence_trainer.train_model(conf.num_epochs, dataset, True)\n\n\n"
  },
  {
    "path": "util.py",
    "content": "\"\"\"util.py: polishing trigger set to use.\n\n1. same trigger in different entity type -> delete\n2. multiple same triggers -> merge it using mean pooling (temporary)\n\nWritten in 2020 by Dong-Ho Lee.\n\"\"\"\nfrom sklearn.manifold import TSNE\nimport matplotlib.pyplot as plt\nimport numpy as np\nimport torch\nfrom collections import Counter\nfrom pytorch_pretrained_bert import BertTokenizer\nfrom pytorch_pretrained_bert import BertModel\nimport os.path\nimport pickle\nfrom tqdm import tqdm\n\n\ndef remove_duplicates(features, labels, triggers, dataset):\n    feature_dict = dict()\n    for feature, label, trigger in zip(features, labels, triggers):\n        if trigger not in feature_dict:\n            feature_dict[trigger] = []\n            feature_dict[trigger].append((feature, label))\n        else:\n            feature_dict[trigger].append((feature, label))\n\n    for key, value in feature_dict.items():\n        embedding = [f[0] for f in feature_dict[key]]\n        embedding = torch.mean(torch.stack(embedding), dim=0)\n        for data in dataset:\n            if key == data.trigger_key:\n                data.trigger_vec = embedding\n\n    duplicate_key = []\n    for key, value in feature_dict.items():\n        labels = [f[1] for f in feature_dict[key]]\n        labels = set(labels)\n        if len(labels) > 1:\n            duplicate_key.append(key)\n\n    for key in duplicate_key:\n        del feature_dict[key]\n\n    for key, value in feature_dict.items():\n        embedding = [f[0] for f in feature_dict[key]]\n        label = feature_dict[key][0][1]\n        embedding = torch.mean(torch.stack(embedding), dim=0)\n        feature_dict[key] = [embedding, label]\n\n    trigger_key = []\n    final_trigger = []\n    for key, value in feature_dict.items():\n        final_trigger.append(feature_dict[key][0])\n        trigger_key.append(key)\n\n    return torch.stack(final_trigger), trigger_key\n\n"
  }
]